Miracle-dz/UniFAR-FTUs huggingface dataset:
Dynamics of temperature dependent modifications of Blood in the near‐infrared

Laser irradiation induces blood coagulation by heating of blood components. It is a complex phenomenon which encompasses a variety of processes, such as cell shape modification, cell membrane rupture, protein denaturation, aggregation, and finally blood gelation. An in vitro study was performed to investigate heating temperatures leading to transformation of blood and to have a better understanding of the dynamics of temperature dependent modifications of blood in the near‐infrared.
Lying about the Valence of Affective Pictures: An fMRI Study

The neural correlates of lying about affective information were studied using a functional magnetic resonance imaging (fMRI) methodology. Specifically, 13 healthy right-handed Chinese men were instructed to lie about the valence, positive or negative, of pictures selected from the International Affective Picture System (IAPS) while their brain activity was scanned by a 3T Philip Achieva scanner. The key finding is that the neural activity associated with deception is valence-related. Comparing to telling the truth, deception about the valence of the affectively positive pictures was associated with activity in the inferior frontal, cingulate, inferior parietal, precuneus, and middle temporal regions. Lying about the valence of the affectively negative pictures, on the other hand, was associated with activity in the orbital and medial frontal regions. While a clear valence-related effect on deception was observed, common neural regions were also recruited for the process of deception about the valence of the affective pictures. These regions included the lateral prefrontal and inferior parietal regions. Activity in these regions has been widely reported in fMRI studies on deception using affectively-neutral stimuli. The findings of this study reveal the effect of valence on the neural activity associated with deception. Furthermore, the data also help to illustrate the complexity of the neural mechanisms underlying deception.
Signature of Circulating MicroRNAs as Potential Biomarkers in Vulnerable Coronary Artery Disease

Aims MicroRNAs (miRNAs) play important roles in the pathogenesis of cardiovascular diseases. Circulating miRNAs were recently identified as biomarkers for various physiological and pathological conditions. In this study, we aimed to identify the circulating miRNA fingerprint of vulnerable coronary artery disease (CAD) and explore its potential as a novel biomarker for this disease. Methods and Results The Taqman low-density miRNA array and coexpression network analyses were used to identify distinct miRNA expression profiles in the plasma of patients with typical unstable angina (UA) and angiographically documented CAD (UA group, n = 13) compared to individuals with non-cardiac chest pain (control group, n = 13). Significantly elevated expression levels of miR-106b/25 cluster, miR-17/92a cluster, miR-21/590-5p family, miR-126*, and miR-451 were observed in UA patients compared to controls. These findings were validated by real-time PCR in another 45 UA patients, 31 stable angina patients, and 37 controls. In addition, miR-106b, miR-25, miR-92a, miR-21, miR-590-5p, miR-126* and miR-451 were upregulated in microparticles (MPs) isolated from the plasma of UA patients (n = 5) compared to controls (n = 5). Using flow cytometry and immunolabeling, we further found that Annexin V+ MPs were increased in the plasma samples of UA patients compared to controls, and the majority of the increased MPs in plasma were shown to be Annexin V+ CD31+ MPs. The findings suggest that Annexin V+ CD31+ MPs may contribute to the elevated expression of the selected miRNAs in the circulation of patients with vulnerable CAD. Conclusion The circulating miRNA signature, consisting of the miR-106b/25 cluster, miR-17/92a cluster, miR-21/590-5p family, miR-126* and miR-451, may be used as a novel biomarker for vulnerable CAD. Trial Registration Chinese Clinical Trial Register, ChiCTR-OCH-12002349.
Cosmic Dust Induced Flux Fluctuations: Bad and Good Aspects

Cosmic dust extinction alters the flux of Type Ia supernovae (SNe Ia). Inhomogeneities in the dust distribution induce correlated fluctuations of the SN fluxes. We find that such correlation can be up to 60% of the signal caused by gravitational lensing magnification, with an opposite sign. Therefore, if not corrected, cosmic dust extinction is the dominant source of systematic uncertainty for future SNe Ia lensing measurement, limiting the overall S/N to be ≲10. On the other hand, SN flux correlation measurements can be used in combination with other lensing data to infer the level of dust extinction. This will provide a viable method to eliminate gray dust contamination from the SN Ia Hubble diagram.
Advanced modularity for building SPL feature models: a model-driven approach

Feature Models are commonly used to specify commonalities and variabilities in Software Product Lines (SPL). Our goal is to enhance feature modeling with traceability and improved support for crosscutting concerns. While traceability will show the features' requirement-origins, providing means to reason about their existence, crosscutting concerns will be handled through advanced modularity mechanisms (e.g. aspects), making the impact of changes to SPL models less difficult to understand and analyze. The result is Theme/SPL, a novel SPL requirements technique based on a concern-driven approach (Theme/Doc). Theme/SPL includes the proposal of a domain-specific language for specifying Theme/Doc models and uses model-driven development to generate automatically feature models from them. We show the applicability of the technique through a case study using a within-group design to evaluate the final results and tools developed.
Integrative Interventions for Men with Concurrent Substance Misuse and Trauma: Roles for Mindfulness and Masculinities

Men experience higher lifetime trauma rates than women, and they use and misuse substances at rates far exceeding women. Men are also reported to experience significantly higher lifetime rates of comorbid posttraumatic stress disorder (PTSD) and substance use disorder (SUD) than women. Although there is agreement in the clinical field of trauma and substance abuse that integrated treatment programs are critical, relapse rates and treatment dropout rates remain relatively high despite the high standards in these programs. Most integrated treatment approaches for co-occurring disorders are based on cognitive-behavioural frameworks that emphasize coping skills and replacing maladaptive cognitions. We address two major gaps in these standard-of-care approaches. First, we examine the context of gender; most programs do not address gender constructs or provide gender-specific materials, and many programs were initially developed for women only. Second, we address the growing evidence for utilizing mindfulness and acceptance components in integrative interventions for men.
CHANGE IN PROFESSIONAL BELIEFS: A CASE STUDY ON HANDLING DISRUPTIVE BEHAVIOURS

Bu calisma, mesleki gelisim esnasinda ogretmen adayinin degisim sureclerini tasvir eden bir ornek olay incelemesidir. Ogretmenlik egitiminin son yilindan baslayarak meslekteki ilk yil boyunca katilimcinin dersin akisini bozan davranislara karsi gelistirdigi stratejiler incelenmistir. Yari yapilandirilmis gorusme, gozlem, senaryo (vignette) odevi ve gunce yoluyla toplanan veriler icerik analizi yontemi ile analiz edilmistir. Katilimci az sayida strateji ile basladigi mesleki gelisimine, meslege basladigi yilda hem strateji sayisini arttirarak hem de kullandigi stratejileri sorgulama ongorusune sahip olarak devam etmistir. Sonuc olarak, katilimcinin mesleki degisiminde tecrube ve hedef kitle bilgisi degisime katkida bulunan ana faktorler olarak bulunmustur.
Exploring Broadband GRB Behavior during γ-Ray Emission

The robotic ROTSE-III telescope network detected prompt optical emission contemporaneous with the γ-ray emission of Swift events GRB 051109A and GRB 051111. Both data sets have continuous coverage at high signal-to-noise levels from the prompt phase onward, and thus the early observations are readily compared to the Swift XRT and BAT high-energy detections. In both cases, the optical afterglow is established, declining steadily during the prompt emission. For GRB 051111, there is evidence of an excess optical component during the prompt emission. The component is consistent with the flux spectrally extrapolated from the γ-rays, using the γ-ray spectral index. A compilation of spectral information from previous prompt detections shows that such a component is unusual. The existence of two prompt optical components—one connected to the high-energy emission, the other to separate afterglow flux, as indicated in GRB 051111—is not compatible with a simple "external-external" shock model for the GRB and its afterglow.
Small fi ber neuropathy – how to start , where to go ?

Small fi ber neuropathy (SFN) is a type of sensory neuropathy which selectively aff ects small diameter somatic and autonomic nerve fi bers. Diagnosis is challenging, given that clinical picture can be diffi cult to interpret. Patients typically present with painful paresthesias and/or signs of autonomic dysfunction. In SFN, neuropathic pain was shown to be a frequent and early symptom, so it is considered as a reliable marker of this neuropathy. Th e diagnosis of SFN relies on clinical features combined with abnormal quantifi cation of intraepidermal nerve fi ber density (IENFD) and/or defi cit in temperature threshold on quantitative sensory testing (QST). SFN is associated with various systemic diseases, among which diabetes was found to be the most common one. Th is knowledge urges a detailed diagnostic work-up of every patient presenting with SFN because new understanding of the SFN etiology could help narrow the proportion of idiopathic SFN patients, which is still large. Most recent discoveries of several novel mutations to sodium channels in patients with idiopathic SFN could help in this area, as well as in the development of specifi c treatment options. For now, the treatment of SFN is very complex. Causative therapy is advised whenever possible and symptomatic treatment should follow newest guidelines on the management of neuropathic
One-Year Mean Follow-up of 41 Patients Treated With Bifurcation Stenting

Forty-one patients, mean age 61 ± 13 years, had stenting of bifurcation coronary artery lesions. Of the 41 patients, a crushing stent was used in 33 patients (80%), a T stent in 6 patients (15%), a kissing stent in 1 patient (2%), and side branch angioplasty in 1 patient (2%). Mean follow-up was 12 months (range 7-17 months). At follow-up, of the 41 patients, none (0%) died, 1 (2%) had a myocardial infarction, 3 (7%) had thrombotic stent occlusion, 3 (7%) had restenosis, 4 (10%) had target lesion revascularization, and 6 (15%) had myocardial infarction or target lesion revascularization or had died.
A comparison of cigarette- and hookah-related videos on YouTube

Objective YouTube is now the second most visited site on the internet. The authors aimed to compare characteristics of and messages conveyed by cigarette- and hookah-related videos on YouTube. Methods Systematic search procedures yielded 66 cigarette-related and 61 hookah-related videos. After three trained qualitative researchers used an iterative approach to develop and refine definitions for the coding of variables, two of them independently coded each video for content including positive and negative associations with smoking and major content type. Results Median view counts were 606 884 for cigarettes-related videos and 102 307 for hookah-related videos (p<0.001). However, the number of comments per 1000 views was significantly lower for cigarette-related videos than for hookah-related videos (1.6 vs 2.5, p=0.003). There was no significant difference in the number of ‘like’ designations per 100 reactions (91 vs 87, p=0.39). Cigarette-related videos were less likely than hookah-related videos to portray tobacco use in a positive light (24% vs 92%, p<0.001). In addition, cigarette-related videos were more likely to be of high production quality (42% vs 5%, p<0.001), to mention short-term consequences (50% vs 18%, p<0.001) and long-term consequences (44% vs 2%, p<0.001) of tobacco use, to contain explicit antismoking messages (39% vs 0%, p<0.001) and to provide specific information on how to quit tobacco use (21% vs 0%, p<0.001). Conclusions Although internet user-generated videos related to cigarette smoking often acknowledge harmful consequences and provide explicit antismoking messages, hookah-related videos do not. It may be valuable for public health programmes to correct common misconceptions regarding hookah use.
Disentangling the roles of parental monitoring and family conflict in adolescents' management of type 1 diabetes.

OBJECTIVE Less parental monitoring of adolescents' diabetes self-care and more family conflict are each associated with poorer diabetes outcomes. However, little is known about how these two family factors relate with one another in the context of self-care and glycemic control. Diabetes self-care was evaluated as a mediator of the associations among parental monitoring, family conflict, and glycemic control in early adolescents with type 1 diabetes. METHODS Adolescent-parent dyads (n = 257) reported on the frequency of parental monitoring, family conflict, and diabetes self-care. Hemoglobin A1c was abstracted from medical charts. Structural equation modeling was used for mediation analysis. RESULTS A mediation model linking parental involvement and family conflict with A1c through diabetes self-care fit the data well. Monitoring and conflict were inversely correlated (β = -0.23, p < .05) and each demonstrated indirect associations with A1c (standardized indirect effects -0.13 and 0.07, respectively) through their direct associations with self-care (β = 0.39, p < .001 and β = -0.19, p < .05, respectively). Conflict also was positively associated with higher A1c (β = 0.31, p < .01). CONCLUSIONS Elevated family conflict and less parental monitoring are risk factors for poorer glycemic control, and diabetes self-care is one mediator linking these variables. Interventions to promote parental monitoring of diabetes management during early adolescence may benefit from emphasizing strategies to prevent or reduce family conflict.
Preconditioning Strategies For Multiphysics Applications : Some Problems

When modeling chemical processes we are concerned with mathematical models of more and more complexity: it is especially the coupling of equations describing different physical phenomena which adds a new level of complexity to the already present difficulties (3D domains, singular perturbations, heavy nonlinearities). In turn, this gives rise to an intolerable large computation time. In the present report, we give a short introduction to some properties of the mathematical models, present a few characteristic applications as well as a few experiences when solving them. Finally, we propose future directions of research.
Reference descriptions of cellular electrophysiology models

UNLABELLED In recent years there has been much development of the fundamental ideas underlying mathematical model curation in regard to models of biology. While much has been achieved in the realms of systems biology and bioinformatics, little progress has been made in relation to cellular electrophysiology modeling. The primary reason for slow progress in this field is the lack of a consistent and machine-readable reference description for a given model. CellML has been widely used to describe mathematical models of cellular electrophysiology in an unambiguous, machine-readable format. Through the use of well-annotated CellML models we propose a standard by which reference descriptions of cellular electrophysiology models can be similarly defined in an unambiguous, software independent, and machine-readable format. Adoption of this standard will provide a consistent technology by which cellular electrophysiology models can be curated. AVAILABILITY http://www.bioeng. nus.edu. sg/compbiolab/p2/
Synaptic patterns of the superficial layers of the superior colliculus of the rat

An electron microscopic study has been undertaken of the upper layers of the superior colliculus, into which run fibers from the retina and visual cortex. Study of the normal synaptic patterns shows large numbers of serial synapses, particularly near the surface of the colliculus. The presynaptic components usually contain round vesicles and the intermediate profiles always contain flattened vesicles. The latter may be dendrites, dendrite‐like or dilatations of such profiles. Degeneration studies indicate that optic terminals are especially dense near the surface and that they are often the presynaptic terminal of a serial synapse. Very few optic terminals occur in the stratum opticum. Cortical afferents from the visual area mostly end deep in the stratum griseum superficiale, and in superficial stratum opticum, usually on small clear profiles.
A new cross-correlation and constant modulus type algorithm for PAM-PSK signals

We address the problem of blind recovery of multiple sources from their linear convolutive mixture with the cross-correlation and constant modulus algorithm. The steady state mean-squared error of this algorithm is first derived to justify the proposal of a new cross-correlation and constant modulus type algorithm for PAM-PSK type non-constant modulus signals. Simulation studies are presented to support the improved steady-state performance of the new algorithm.
Time Machine: A Mobile Augmented Reality System for Tourism Based on Coded-Aperture Camera

Time Machine is an Augmented Reality (AR) system for enhancing tourists' traveling experience. Based on optimized panoramic images, we proposed a novel spatiotemporal interactive approach which imbues users the ability to interact with both the spatial world and its history. Time machine utilizes panorama of a specific place at different time for achieving interactions with temporal dimension. It also adopts interior panorama of landmark building which can be used by the user to interact with the physical world. Additionally, the panoramas optimized by aperture-coded camera can alleviate the noisy foreground information such as crowds and address defocus blurring to improve the quality of panorama.
Prevalence of vitamin D deficiency in HIV-positive, antiretroviral treatment-naïve patients in a single centre study

The objective of this study was to describe the prevalence of vitamin D deficiency among antiretroviral treatment-naïve, HIV-positive individuals. We reviewed records of consecutive antiretroviral treatment-naïve patients, registering for care for the first time at a London clinic from 01 January 2008 to 31 December 2009. During this period, serum 25-hydroxycholecalciferol was measured routinely for all new patients. 25-hydroxycholecalciferol deficiency and severe deficiency were defined as ≤50 and ≤25 nmol/L, respectively. Among 253 patients (82% men, median age 36 years, 64% white ethnicity), 148 (58.5%) were 25-hydroxycholecalciferol-deficient, including 32 (12.6%) who were severely deficient. In all, 73.5% (61/83) patients of non-white ethnicity were 25-hydroxycholecalciferol-deficient compared with 50.7% (76/150) of those reporting white ethnicity (p < 0.001). Seven of eight (87.5%) patients with hypocalcaemia (<2.12 nmol/L) were 25-hydroxycholecalciferol-deficient. The prevalence of 25-hydroxycholecalciferol-deficiency was higher in winter and spring vs. summer and autumn (89/129 [69.0%] vs. 59/124 [47.6%], p < 0.001). Serum 25-hydroxycholecalciferol deficiency was not associated with gender, CD4 count, HIV viral load or clinical stage. Serum 25-hydroxycholecalciferol deficiency was common among antiretroviral treatment-naïve patients, with those of non-white ethnicity at highest risk. CD4 count, HIV viral load and HIV clinical staging do not help to identify those at risk, but low serum calcium should prompt investigation of 25-hydroxycholecalciferol levels.
Improving Mental Health Care for Transgender Consumers: Providers’ Attitudes, Knowledge, and Resources

Transgender individuals may present for treatment with a variety of mental health needs, both related and peripheral to their gender identity and expression. Compounding stigma and other life stressors elevate mental health risks in transgender communities, and the barriers to mental health services are manifold. As such, the current research study was designed to determine the competency of mental health care providers to address the unique needs of transgender consumers. Online surveys gauged mental health providers’ knowledge of transgender issues, implicit and explicit transphobic attitudes, as well as treatment decisions with transgender and cisgender consumers; moreover, workplace resources and infrastructure were assessed. Three hypotheses were tested: (1) that types of providers (i.e., different degrees and training) would vary on their implicit transphobic attitudes, explicit transphobic attitudes, and transgender-related knowledge; (2) that explicit and implicit attitudes would predict treatment of transgender consumers; and (3) that knowledge would be predictive of implicit and explicit attitudes. While implicit attitudes were not found to be significant in any of these hypotheses, explicit attitudes varied across provider types, F(4,69) = 7.025, p < . 01, and were significantly correlated with knowledge b = -. 481, t(79) = -4.875, p < . 001. Knowledge also varied significantly across provider type F(4,66) = 2.65, p = . 041. Finally, explicit attitudes were significantly correlated with differences in treatment decisions in working with transgender and cisgender consumers b = . 333, t(60) = 2.735, p = . 008. These results suggest that improving transgender-related competencies among mental health providers might facilitate reductions in explicit biases, thereby alleviating certain instances of discriminatory treatment toward transgender individuals in mental health care settings. Implications for advocacy and organizational change are discussed.
Injury in snow and ice sports

This edition of Hazard provides an overview of fatal and hospital-treated injuries in snow and ice sports in Victoria over the 3-year period January 2004 to December 2006. The National Coroners Information System (NCIS) provided data on fatalities and hospital-treated cases were extracted from two datasets held by VISU: the Victorian Admitted Episode Dataset (VAED) and the Victorian Emergency Minimum Dataset (VEMD). Recommended preventive measures should be considered for implementation in the 2008 season.