Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploring N-acyl-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-enes as 11β-HSD1 Inhibitors

We recently found that a cyclohexanecarboxamide derived from 4-azatetracyclo[5.3. 2.02,6.08,10]dodec-11-ene displayed low nanomolar inhibition of 11β-HSD1. In continuation of our efforts to discover potent and selective 11β-HSD1 inhibitors, herein we explored several replacements for the cyclohexane ring. Some derivatives exhibited potent inhibitory activity against human 11β-HSD1, although with low selectivity over the isoenzyme 11β-HSD2, and poor microsomal stability.
Response of turkey poults to tiered levels of Natuphos phytase added to soybean meal-based semi-purified diets containing three levels of nonphytate phosphorus.

A 3-wk feeding trial using 920 day-old turkey poults was conducted to evaluate the addition of seven levels of phytase (Natuphos; 0, 200, 400, 600, 800, 1,000, and 1,200 U/kg of diet) to diets containing three levels of nonphytate P (nP) (.27, .36, and .45%). A positive control diet contained . 60% nP. Semi-purified basal diets contained soybean meal as the only protein source. The increase in BW gain from added phytase was greatest for the lowest nP diet (nP by phytase interaction, P < .001). At . 27% nP, gains improved (P < .001) to 800 U of phytase/kg of diet and then reached a plateau. At . 36 and . 45% nP, increases in gains were observed only for 200 U of phytase/kg of diet. The highest phytase addition to.36 and . 45% nP diets produced gains equal to those of the positive control diet. Feed intake increases paralleled those of BW gains. Gain:feed was lowest for the . 27% nP diets without phytase, but improved (P < .001) to 800 U of phytase/kg of diet and then reached a plateau. The high incidence of leg disorders and high mortality (40%) observed for the poults fed the . 27% nP diet without added phytase declined with the addition of 200 to 400 U of phytase/kg of diet. Ash percentage of toes and tibias increased as the levels of nP (P < .001) and phytase (P < .01) increased; the magnitude of the response to phytase decreased as nP in the diet increased, resulting in an nP by phytase interaction (P < .001). Tibial shear force and stress responded in a similar manner to increasing levels of nP and added phytase. Results show that 652 U of microbial phytase is equivalent to 1 g of P from defluorinated phosphate in turkey starter diets using soybean meal as the only source of phytate P. The response per 100 U of phytase decreased as the total amount of phytase added was increased.
Genetic and Environmental Causes of Variation in the Difference Between Biological Age Based on DNA Methylation and Chronological Age for Middle-Aged Women

The disease- and mortality-related difference between biological age based on DNA methylation and chronological age (Δage) has been found to have approximately 40% heritability by assuming that the familial correlation is only explained by additive genetic factors. We calculated two different Δage measures for 132 middle-aged female twin pairs (66 monozygotic and 66 dizygotic twin pairs) and their 215 sisters using DNA methylation data measured by the Infinium HumanMethylation450 BeadChip arrays. For each Δage measure, and their combined measure, we estimated the familial correlation for MZ, DZ and sibling pairs using the multivariate normal model for pedigree analysis. We also pooled our estimates with those from a former study to estimate weighted average correlations. For both Δage measures, there was familial correlation that varied across different types of relatives. No evidence of a difference was found between the MZ and DZ pair correlations, or between the DZ and sibling pair correlations. The only difference was between the MZ and sibling pair correlations (p < .01), and there was marginal evidence that the MZ pair correlation was greater than twice the sibling pair correlation (p < .08). For weighted average correlation, there was evidence that the MZ pair correlation was greater than the DZ pair correlation (p < .03), and marginally greater than twice the sibling pair correlation (p < .08). The varied familial correlation of Δage is not explained by additive genetic factors alone, implying the existence of shared non-genetic factors explaining variation in Δage for middle-aged women.
Phosphorus in the nutrition of the adult hen. 3. The influence of phosphorus source and level on cage layer osteoporosis (cage layer fatigue).

Abstract DURING a series of experiments conducted in this laboratory between 1961 and 1967 on the relative availability of phosphorus from various sources for caged hens, unexpected mortality was observed to which osteoporosis appeared to be a major contributing factor. The syndrome resembled “cage layer fatigue” (CLF) as first described by Couch (1955) and later in greater detail by Grumbles (1959). A similar condition has since been reported elsewhere in the world by Bell and Siller (1962, Scotland), Gardiner (1964, Ireland), Smetana (1965, Australia), and Hartwigk (1966, Germany). Genetic differences in susceptibility were reported by Francis (1957) based on variations in incidence of CLF from 0.65% to 3.95% in seven strains of birds. Several reports have implicated skeletal weakness or damage in the condition. Urist and Deutsch (1960) described severe osteoporosis in White Leghorn hens in heavy egg production and noted that it did not occur in immature and young mature…
Acoustic wave-equation-based earthquake location

S U M M A R Y We present a novel earthquake location method using acoustic wave-equation-based traveltime inversion. The linear relationship between the location perturbation (δt0, δxs) and the resulting traveltime residual δt of a particular seismic phase, represented by the traveltime sensitivity kernel K(t0, xs) with respect to the earthquake location (t0, xs), is theoretically derived based on the adjoint method. Traveltime sensitivity kernel K(t0, xs) is formulated as a convolution between the forward and adjoint wavefields, which are calculated by numerically solving two acoustic wave equations. The advantage of this newly derived traveltime kernel is that it not only takes into account the earthquake–receiver geometry but also accurately honours the complexity of the velocity model. The earthquake location is obtained by solving a regularized least-squares problem. In 3-D realistic applications, it is computationally expensive to conduct full wave simulations. Therefore, we propose a 2.5-D approach which assumes the forward and adjoint wave simulations within a 2-D vertical plane passing through the earthquake and receiver. Various synthetic examples show the accuracy of this acoustic wave-equationbased earthquake location method. The accuracy and efficiency of the 2.5-D approach for 3-D earthquake location are further verified by its application to the 2004 Big Bear earthquake in Southern California.
Krüppel-like factors in mammalian stem cells and development

Krüppel-like factors (KLFs) are a family of zinc-finger transcription factors that are found in many species. Recent studies have shown that KLFs play a fundamental role in regulating diverse biological processes such as cell proliferation, differentiation, development and regeneration. Of note, several KLFs are also crucial for maintaining pluripotency and, hence, have been linked to reprogramming and regenerative medicine approaches. Here, we review the crucial functions of KLFs in mammalian embryogenesis, stem cell biology and regeneration, as revealed by studies of animal models. We also highlight how KLFs have been implicated in human diseases and outline potential avenues for future research. Summary: This Primer article provides an overview of Krüppel-like factors (KLFs), a family of zinc-finger transcription factors that play fundamental roles in development.
Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice

Abstract Aims: Loss-of-function mutations in GBA1, which cause the autosomal recessive lysosomal storage disease, Gaucher disease (GD), are also a key genetic risk factor for the α-synucleinopathies, including Parkinson's disease (PD) and dementia with Lewy bodies. GBA1 encodes for the lysosomal hydrolase glucocerebrosidase and reductions in this enzyme result in the accumulation of the glycolipid substrates glucosylceramide and glucosylsphingosine. Deficits in autophagy and lysosomal degradation pathways likely contribute to the pathological accumulation of α-synuclein in PD. In this report we used conduritol-β-epoxide (CBE), a potent selective irreversible competitive inhibitor of glucocerebrosidase, to model reduced glucocerebrosidase activity in vivo, and tested whether sustained glucocerebrosidase inhibition in mice could induce neuropathological abnormalities including α-synucleinopathy, and neurodegeneration. Results: Our data demonstrate that daily systemic CBE treatment over 28 days caused accumulation of insoluble α-synuclein aggregates in the substantia nigra, and altered levels of proteins involved in the autophagy lysosomal system. These neuropathological changes were paralleled by widespread neuroinflammation, upregulation of complement C1q, abnormalities in synaptic, axonal transport and cytoskeletal proteins, and neurodegeneration. Innovation: A reduction in brain GCase activity has been linked to sporadic PD and normal aging, and may contribute to the susceptibility of vulnerable neurons to degeneration. This report demonstrates that systemic reduction of GCase activity using chemical inhibition, leads to neuropathological changes in the brain reminiscent of α-synucleinopathy. Conclusions: These data reveal a link between reduced glucocerebrosidase and the development of α-synucleinopathy and pathophysiological abnormalities in mice, and support the development of GCase therapeutics to reduce α-synucleinopathy in PD and related disorders. Antioxid. Redox Signal. 23, 550–564.
On-Farm Evaluation of Hermetic Technology Against Maize Storage Pests in Kenya

Abstract On-farm trial with a total of 32 farmers in eight villages of Naivasha and Nakuru areas of Kenya was conducted between December 2013 and September 2014 to evaluate hermetic grain storage technologies under farmers’ management conditions. The storage technologies evaluated were metal silo and SuperGrain IV-R bag alongside the standard woven polypropylene bag with or without Actellic super dust. Moisture content, insect population, grain discoloration, and weight loss were analyzed 90, 180, and 270 d after storage. Grain moisture content remained stable over the storage period. Both metal silo and SuperGrain IV-R bag suppressed insect population, prevented grain loss and cross-infestation of insects from the surrounding environment. On the contrary, polypropylene bags allowed rapid build up of insect population and re-infestation from the surrounding environment. Grain weight losses were 1.5% in the metal silo and 1.8% in the SuperGrain IV-R bags compared to 32% in the polypropylene bags without Actellic Super dust, 270 d after storage. The present study, therefore, demonstrates that storing grains either in metal silo or SuperGrain IV-R bags would benefit farmers in reducing grain losses and improving quality. The study was of great interest to the farmers, grain storage scientists, and food security experts.
Time-Frequency Analysis of Accelerometry Data for Detection of Myoclonic Seizures

Four time-frequency and time-scale methods are studied for their ability of detecting myoclonic seizures from accelerometric data. Methods that are used are: the short-time Fourier transform (STFT), the Wigner distribution (WD), the continuous wavelet transform (CWT) using a Daubechies wavelet, and a newly introduced model-based matched wavelet transform (MOD). Real patient data are analyzed using these four time-frequency and time-scale methods. To obtain quantitative results, all four methods are evaluated in a linear classification setup. Data from 15 patients are used for training and data from 21 patients for testing. Using features based on the CWT and MOD, the success rate of the classifier was 80%. Using STFT or WD-based features, the classification success is reduced. Analysis of the false positives revealed that they were either clonic seizures, the onset of tonic seizures, or sharp peaks in “normal” movements indicating that the patient was making a jerky movement. All these movements are considered clinically important to detect. Thus, the results show that both CWT and MOD are useful for the detection of myoclonic seizures. On top of that, MOD has the advantage that it consists of parameters that are related to seizure duration and intensity that are physiologically meaningful. Furthermore, in future work, the model can also be useful for the detection of other motor seizure types.
Cognitive Processing Therapy for Spanish-speaking Latinos: A Formative Study of a Model-Driven Cultural Adaptation of the Manual to Enhance Implementation in a Usual Care Setting.

OBJECTIVE As part of a larger implementation trial for cognitive processing therapy (CPT) for posttraumatic stress disorder (PTSD) in a community health center, we used formative evaluation to assess relations between iterative cultural adaption (for Spanish-speaking clients) and implementation outcomes (appropriateness and acceptability) for CPT. METHOD Qualitative data for the current study were gathered through multiple sources (providers: N = 6; clients: N = 22), including CPT therapy sessions, provider fieldnotes, weekly consultation team meetings, and researcher fieldnotes. Findings from conventional and directed content analysis of the data informed refinements to the CPT manual. RESULTS Data-driven refinements included adaptations related to cultural context (i.e., language, regional variation in wording), urban context (e.g., crime/violence), and literacy level. Qualitative findings suggest improved appropriateness and acceptability of CPT for Spanish-speaking clients. CONCLUSION Our study reinforces the need for dual application of cultural adaptation and implementation science to address the PTSD treatment needs of Spanish-speaking clients.
Dietary n-3 fatty acids reduce antibody-dependent cell cytotoxicity and alter eicosanoid release by chicken immune cells.

The overall goal of the present study was to determine whether the incorporation of n-3 fatty acids into poultry rations would alter the immune response of broiler chickens. Female broiler chicks were fed a corn and soybean meal-based diet to which one of four dietary fats were added: lard (LA), corn oil (CO), flaxseed oil (SO), or menhaden fish oil (FO). The latter two fat sources are rich in n-3 polyunsaturated fatty acids (PUFA). Enriching the diet with n-3 PUFA did not alter the primary or secondary antibody response of broiler chickens to sheep red blood cells. Dietary fat source had no effect on antibody-dependent cell cytotoxicity (ADCC) by peripheral blood leukocytes, but ADCC by splenocytes was 50% lower in chickens fed SO and FO compared with LA and CO (P less than .005). As expected, the fatty acid profile of the isolated immune cells reflected the fatty acid composition of the dietary fats fed. Basal release and calcium ionophore (A23187)-stimulated (10 microM) release of thromboxane B were significantly lower (P less than .05) in the SO and FO groups compared with the LA and CO groups. Total leukotriene B release was not significantly altered by dietary fat source. In conclusion, feeding broiler chickens diets rich in n-3 PUFA reduced ADCC of splenocytes and altered eicosanoid production by isolated immune cells.
Magic always comes with a price: Utility versus security for bank cards

Nowadays, coins and banknotes are familiar to us and, on a daily basis, we make cash payments of small amounts of less than 10 Euros. However, concerning high amounts, we cannot pay for everything in cash: firstly because the conservation of cash is risky and, secondly, in the case of loss or fraud, there is no recourse. Therefore, according to several recent studies, the most preferred and used method of payment is the bank card for amounts in excess of 10 Euros. In fact, the bank card has more advantages than the cash: it allows to make payments on the internet (online), avoids having to carry cash, being simple to obtain by banks, being very convenient to make payments in stores or to withdraw money with, as well as it is readily accepted for multiple currencies (in different countries), small in size and easy to carry. In this paper, we present an overview of bank cards, their advantages/disadvantages and types of card payment, then we discuss their security.
Coordination in a Multi-Cell Multi-Antenna Multi-User W-CDMA System: A Beamforming Approach

The problem of designing joint power control and optimal beamforming (JPCOB) algorithms for the downlink of a coordinated multi-cell WCDMA system is considered throughout this paper. In this case, the JPCOB design is formulated as the problem of minimizing the total transmitted power in the coordinated multi-cell system, subject to a certain quality of service requirement for each user. In this paper, the performance of two JPCOB algorithms based on different beamforming approaches is compared over the coordinated multi-cell system. The first one, obtains local beamformers by means of the well-known virtual uplink-downlink duality. In contrast, the second algorithm implements multi-base beamformers, taking into account match filter equalizers at the receivers. Moreover, realistic system parameters, such as per-base station power constraints or the asynchronous nature of the signals arriving at the receivers, are taken into account. Simulation results show that the algorithm based on multi-base beamforming presents attractive properties, such as an inherent multi-base scheduling technique or a decreasing total transmitted power as the degree of coordination between base stations is increased.
Selection for 8-week body weight in normal and dwarf chickens under different water/feed environments.

Normal and dwarf chickens fed either regular (.4%) or high (1.6%) salt diets were selected for four generations for high 8-wk body weight. Selection gains in body weight were greater in dwarf than in normal genotypes. Selections differentials, gains, and heritabilities were greater in lines selected under the . 4% salt environment. When tested females were fed . 4% salt diets, normal females from lines selected after being fed 1.6% salt diets had less fat than those from lines selected after being fed . 4% salt diets. However, no differences were observed in dwarf females from the two selection environments.
Fibrocytes in Asthma and Chronic Obstructive Pulmonary Disease: Variations on the Same Theme

Abstract Fibrocytes are circulating cells that have fibroblast properties. They are produced by the bone marrow stroma, and they move from the blood to injured organs using multiple chemokine pathways. They exhibit marked functional and phenotypic plasticity in response to the local tissue microenvironment to ensure a proinflammatory or a more resolving phenotype. They can adopt immune cell properties and modulate conventional immune cell functions. Although their exact function is not always clear, they have emerged as key effector cells in several fibrotic diseases such as keloid, scleroderma, and idiopathic pulmonary fibrosis. Recent evidence suggests that fibrocytes could contribute to bronchial obstructive diseases such as asthma and chronic obstructive pulmonary disease. This review summarizes the reported roles of fibrocytes and their pathways into the lung in the context of asthma and chronic obstructive pulmonary disease, provides an overview of the different roles played by fibrocytes, and discusses their possible contributions to these obstructive diseases.
Understanding the Geometry of Connected Fracture Flow with Multiperiod Oscillatory Hydraulic Tests

An understanding of the spatial and hydraulic properties of fast preferential flow pathways in the subsurface is necessary in applications ranging from contaminant fate and transport modeling to design of energy extraction systems. One method for the characterization of fracture properties over interwellbore scales is Multiperiod Oscillatory Hydraulic (MOH) testing, in which the aquifer response to oscillatory pressure stimulations is observed. MOH tests were conducted on isolated intervals of wells in siliciclastic and carbonate aquifers in southern Wisconsin. The goal was to characterize the spatial properties of discrete fractures over interwellbore scales. MOH tests were conducted on two discrete fractured intervals intersecting two boreholes at one field site, and a nest of three piezometers at another field site. Fracture diffusivity estimates were obtained using analytical solutions that relate diffusivity to observed phase lag and amplitude decay. In addition, MOH tests were used to investigate the spatial extent of flow using different conceptual models of fracture geometry. Results indicated that fracture geometry at both field sites can be approximated by permeable two‐dimensional fracture planes, oriented near‐horizontally at one site, and near‐vertically at the other. The technique used on MOH field data to characterize fracture geometry shows promise in revealing fracture network characteristics important to groundwater flow and transport.
Coping and quality of life after tumor surgery: Personal and social resources promote different domains of quality of life

Abstract Personal and social resources facilitate the adaptation to critical life events. The present study investigates whether general self-efficacy beliefs and received social support elevate cancer patients’ physical, emotional, and social well-being directly, or whether these effects are rather mediated by active or meaning-focused coping. Gastrointestinal, colorectal, and lung cancer patients were approached at 1 month and at 6 months after surgery (N=175). Structural equation models indicate that self-efficacy at 1 month after surgery exerted a positive direct effect on all three domains of health-related quality of life at 6 months after surgery, but indirect effects through active and meaning-focused coping were also observed. Initial received support elevated later emotional well-being, but not the other two quality of life domains. This effect was not mediated by coping. Results suggest the development of interventions to increase optimistic self-beliefs and coping skills in tumor-surgery patients.
Yeasts of the soil – obscure but precious

Pioneering studies performed in the nineteenth century demonstrated that yeasts are present in below‐ground sources. Soils were regarded more as a reservoir for yeasts that reside in habitats above it. Later studies showed that yeast communities in soils are taxonomically diverse and different from those above‐ground. Soil yeasts possess extraordinary adaptations that allow them to survive in a wide range of environmental conditions. A few species are promising sources of yeast oils and have been used in agriculture as potential antagonists of soil‐borne plant pathogens or as plant growth promoters. Yeasts have been studied mainly in managed soils such as vineyards, orchards and agricultural fields, and to a lesser extent under forests and grasslands. Our knowledge of soil yeasts is further biased towards temperate and boreal forests, whereas data from Africa, the Americas and Asia are scarce. Although soil yeast communities are often species‐poor in a single sample, they are more diverse on the biotope level. Soil yeasts display pronounced endemism along with a surprisingly high proportion of currently unidentified species. However, like other soil inhabitants, yeasts are threatened by habitat alterations owing to anthropogenic activities such as agriculture, deforestation and urbanization. In view of the rapid decline of many natural habitats, the study of soil yeasts in undisturbed or low‐managed biotopes is extremely valuable. The purpose of this review is to encourage researchers, both biologists and soil scientists, to include soil yeasts in future studies.