Miracle-dz/UniFAR-FTUs huggingface dataset:
Arthrography, clinical examination, and stress radiograph in the diagnosis of acute injury to the lateral ligaments of the ankle

We examined 188 consecutive patients, each of whom had an acute ankle sprain, using clinical stability as sessment, stress radiographs, and arthrography to compare the reliability of these methods used in diag nosing lateral ligament ruptures of the ankle. Sixty-six of the ankles were treated operatively. Arthrography accurately detected ligament damage in all of the pa tients with this injury and revealed the extent of the injury in about 85%, whereas clinical examination and stress radiographs detected only about half of the injuries. The injuries and the results of these two meth ods were often controversial, as our study will show.
Family study of affective spectrum disorder.

BACKGROUND Affective spectrum disorder (ASD) represents a group of psychiatric and medical conditions, each known to respond to several chemical families of antidepressant medications and hence possibly linked by common heritable abnormalities. Forms of ASD include major depressive disorder (MDD), attention-deficit/hyperactivity disorder, bulimia nervosa, cataplexy, dysthymic disorder, fibromyalgia, generalized anxiety disorder, irritable bowel syndrome, migraine, obsessive-compulsive disorder, panic disorder, posttraumatic stress disorder, premenstrual dysphoric disorder, and social phobia. Two predictions of the ASD hypothesis were tested: that ASD, taken as a single entity, would aggregate in families and that MDD would coaggregate with other forms of ASD in families. METHODS Probands with and without MDD, together with their first-degree relatives, were interviewed using the Structured Clinical Interview for DSM-IV and a supplemental interview for other forms of ASD. The familial aggregation and coaggregation of disorders were analyzed using proband predictive logistic regression models, including a novel bivariate model for the presence or absence of each of 2 disorders in a relative as predicted by the presence or absence of each of 2 disorders in the associated proband. RESULTS In the 178 interviewed relatives of 64 probands with MDD and 152 relatives of 58 probands without MDD, the estimated odds ratio (95% confidence interval) for the familial aggregation of ASD as a whole was 2.5 (1.4-4.3; P =.001) and for the familial coaggregation of MDD with at least one other form of ASD was 1.9 (1.1-3.2; P =.02). CONCLUSIONS Affective spectrum disorder aggregates strongly in families, and MDD displays a significant familial coaggregation with other forms of ASD, taken collectively. These results suggest that forms of ASD may share heritable pathophysiologic features.
Characterization of plasma membrane redox activity from ehrlich cells

Ferricyanide reductase activity of plasma membranes isolated from Ehrlich ascites tumour cells was very sensitive to trypsin treatment. The decreases of activity observed after treatment with different glycosidases suggests that ferricyanide reductase is a glycoprotein. The opposite effects of phospholipase A2 and phospholipase C on the redox activity indicate that the phospholipidic environment plays an important role in the function of ferricyanide reductase. Sodium ions at millimolar concentrations, and some divalent cations at micromolar concentrations (Ca2+, Mg2+, Sr2+, and Mn2+) behaved as stimulators of ferricyanide reductase activity.
Macular thickness changes in glaucomatous optic neuropathy detected using optical coherence tomography.

OBJECTIVE To correlate macular thickness and retinal nerve fiber layer (RNFL) thickness in normal and glaucomatous eyes using optical coherence tomography. METHODS Complete examination, automated achromatic perimetry, and optical coherence tomography of the peripapillary RNFL and macula were performed. Exclusion criteria were visual acuity of less than 20/40, diseases other than glaucoma, and unreliable automated achromatic perimetry. Macular thickness measurements were generated using 6 radial optical coherence tomographic scans (5.9 mm) centered on the fovea, and mean and quadrantic macular thickness values were calculated. RESULTS Fifty-nine eyes of 59 patients (29 normal and 30 glaucomatous) were enrolled (mean +/- SD age, 56.7 +/- 20.3 years; range, 20-91 years). All eyes with glaucoma had associated visual field loss (mean +/- SD mean defect, -8.4 +/- 5.8 dB). Mean macular thickness was significantly associated with visual field mean defect (R2 = 0.47; P<.001), pattern standard deviation (R2 = 0.32; P<.001), and mean RNFL thickness (R2 = 0.38; P<.001). In glaucomatous eyes with visual field loss localized to 1 hemifield (n = 11), mean +/- SD macular thickness in the quadrant associated with the field defect (277 +/- 28 micro m) was significantly less (P =.005) than in the unaffected quadrant (286 +/- 27 micro m). Mean RNFL thickness in the affected quadrant (89 +/- 53 micro m) was significantly thinner (P =.009) than in the unaffected quadrant (121 +/- 39 micro m). MAIN OUTCOME MEASURES Mean total and quadrantic macular and RNFL thickness measurements. CONCLUSIONS Macular thickness changes are well correlated with changes in visual function and RNFL structure in glaucoma and may be a surrogate indicator of retinal ganglion cell loss.
A Structural Basis for CD8+ T Cell-dependent Recognition of Non-homologous Peptide Ligands

Molecular mimicry of self-epitopes by viral antigens is one possible pathogenic mechanism underlying induction of autoimmunity. A self-epitope, mDBM, derived from mouse dopamine β-mono-oxygenase (KALYDYAPI) sharing 44% sequence identity with the lymphocytic choriomeningitis virus-derived immunodominant epitope gp33 (KAVYNFATC/M), has previously been identified as a cross-reactive self-ligand, presentation of which results in autoimmunity. A rat peptide homologue, rDBM (KALYNYAPI, 56% identity to gp33), which displayed similar properties to mDBM, has also been identified. We herein report the crystal structure of H-2Db·rDBM and a comparison with the crystal structures of the cross-reactive H-2Db·gp33 and non-cross-reactive H-2Db·gp33 (V3L) escape variant (KALYNFATM, 88% identity to gp33). Despite the large sequence disparity, rDBM and gp33 peptides are presented in nearly identical manners by H-2Db, with a striking juxtaposition of the central sections of both peptides from residues p3 to p7. The structural similarity provides H-2Db in complex with either a virus-derived or a dopamine β-mono-oxygenase-derived peptide with a shared antigenic identity that conserves the positioning of the heavy chain and peptide residues that interact with the T cell receptor (TCR). This stands in contrast to the structure of H-2Db·gp33 (V3L), in which a single conserved mutation, also present in rDBM, induces large movements of both the peptide backbone and the side chains that interact with the TCR. The TCR-interacting surfaces of the H-2Db·rDBM and H-2Db·gp33 major histocompatibility complexes are very similar with regard to shape, topology, and charge distribution, providing a structural basis for CD8 T cell activation by molecular mimicry and potential subsequent development of autoreactivity.
Embodied and Situated Language Processing : Stepping out of the Frame 29-30 Jul

Background and Purpose: Ruminations involve repetitive, prolonged, and recurrent thoughts about one’s self, concerns and experiences. These thoughts are predominantly verbal and can be considered as a particular case of inner speech. It has been suggested that inner speech is a kind of motor action. In line with this suggestion, we predicted an increase of speech muscle activity during verbal rumination as compared to rest (following a relaxation session). Furthermore, we expected that orofacial relaxation might reduce speech muscle activity and lead to a decrease in inner verbal productions. Method: We recorded lip (i.e., orbicularis oris superior, OOS), forehead (i.e., frontalis, Front) and forearm (for control) muscle activity in 33 participants, using surface electromyography (EMG). Ruminative state was assessed via subjective reports at three consecutive points: after a first relaxation session (initial resting state), after a rumination induction procedure (involving a forced-failure task) and after a second relaxation session or a distraction task (listening to a story, control condition). Results: Results showed an increase in EMG activity in the OOS and Front muscles after rumination induction compared to the initial relaxed state. This increase in orofacial EMG activity was associated with positive subjective reports of rumination and was not due to general muscular tension because there was no increase in forearm EMG. Furthermore, preliminary analyses suggested a decrease in orofacial EMG activity following the relaxation session and no decrease after the control distraction condition. Conclusion: The observed increased OOS activity after rumination induction corroborates the ∗Speaker †Corresponding author: ladislas.nalborczyk@gmail.com ‡Corresponding author: helene.loevenbruck@upmf-grenoble.fr §Corresponding author: marcela.perrone-bertolotti@upmf-grenoble.fr
Host Response to Malaria During Pregnancy: Placental Monocyte Recruitment Is Associated with Elevated β Chemokine Expression1

Malaria during pregnancy is associated with poor birth outcomes, particularly low birth weight. Recently, monocyte infiltration into the placental intervillous space has been identified as a key risk factor for low birth weight. However, the malaria-induced chemokines involved in recruiting and activating placental monocytes have not been identified. In this study, we determined which chemokines are elevated during placental malaria infection and the association between chemokine expression and placental monocyte infiltration. Placental malaria infection was associated with elevations in mRNA expression of three β chemokines, macrophage-inflammatory protein 1 (MIP-1) α (CCL3), monocyte chemoattractant protein 1 (MCP-1; CCL2), and I-309 (CCL1), and one α chemokine, IL-8 (CXCL8); all correlated with monocyte density in the placental intervillous space. Placental plasma concentrations of MIP-1α and IL-8 were increased in women with placental malaria and were associated with placental monocyte infiltration. By immunohistochemistry, we localized placental chemokine production in malaria-infected placentas: some but not all hemozoin-laden maternal macrophages produced MIP-1β and MCP-1, and fetal stromal cells produced MCP-1. In sum, local placental production of chemokines is increased in malaria, and may be an important trigger for monocyte accumulation in the placenta.
Hyperhomocysteinemia and Atherothrombotic Disease

Hyperhomocysteinemia is an independent risk factor for atherothrombotic disease. The mechanism by which homocysteine induces atherosclerosis and thrombosis is not fully understood. Data on arterial histology in humans with homocystinuria and mild hyperhomocysteinemia are limited. In vitro studies as well as studies in animals and humans indicate that hyperhomocysteinemia induces dysfunction of the vascular endothelium, with loss of endothelium-dependent vasodilation and endothelial antithrombotic properties, and proliferation of vascular smooth muscle cells, which are key processes in current models of atherogenesis and thrombosis. One of the hypotheses is that homocysteine can lead to cellular dysfunction through a mechanism involving oxidative damage but future studies in humans are needed to confirm this. Studies in hyperhomocysteinemic vascular patients have shown that endothelial antithrombotic properties appear to be more severely impaired than in similar patients with normohomocysteinemia. Furthermore, impaired endothelium-dependent vasodilation has been observed in clinically healthy hyperhomocysteinemic subjects in whom no abnormalities were found in endothelial antithrombotic properties. Future studies involving homocysteine-lowering treatment in hyperhomocysteinemic patients with vascular disease and in clinically healthy hyperhomocysteinemic subjects are necessary to investigate the mechanisms by which homocysteine causes atherothrombotic disorders in humans.
Nomenclature of the apatite supergroup minerals

The apatite supergroup includes minerals with a generic chemical formula IX M12 VII M23( IV TO4)3 X( Z ¼ 2); chemically they can be phosphates, arsenates, vanadates, silicates, and sulphates. The maximum space group symmetry is P63/m, but several members of the supergroup have a lower symmetry due to cation ordering and deviations from the ideal topology, which may result in an increase of the number of the independent sites. The apatite supergroup can be formally divided into five groups, based on crystal-chemical arguments: apatite group, hedyphane group, belovite group, britholite group, and ellestadite group. The abundance of distinct ions which may be hosted at the key-sites (M ¼ Ca 2þ , Pb 2þ , Ba 2þ , Sr 2þ , Mn 2þ , Na þ , Ce 3þ , La 3þ ,Y 3þ , Bi 3þ ;T ¼ P 5þ , As 5þ ,V 5þ , Si 4þ ,S 6þ ,B 3þ ;X ¼ F � , (OH) � , Cl � ) result in a large number of compositions which may have the status of distinct mineral species. Naming of apatite supergroup minerals in the past has resulted in nomenclature inconsistencies and problems. Therefore, an ad hoc IMA-CNMNC Subcommittee was established with the aim of rationalizing the nomenclature within the apatite supergroup and making some order among existing and potentially new mineral species. In addition to general recommendations for the handling of chemical (EPMA) data and for the allocation of ions within the various sites, the main recommendations of this subcommittee are the following: 1. Nomenclature changes to existing minerals. The use of adjectival prefixes for anions is to be preferred instead of modified Levinson suffixes; accordingly, six minerals should be renamed as follows: apatite-(CaF) to fluorapatite, apatite-(CaOH) to hydroxylapatite, apatite-(CaCl) to chlorapatite, ellestadite-(F) to fluorellestadite, ellestadite-(OH) to hydroxylellestadite, phospho- hedyphane-(F) to fluorphosphohedyphane. For the apatite group species these changes return the names that have been used in thousands of scientific paper, treatises and museum catalogues over the last 150 years. The new mineral IMA 2008-009, approved without a name, is here named stronadelphite. Apatite-(SrOH) is renamed fluorstrophite. Deloneite-(Ce) is renamed deloneite. The new mineral IMA 2009-005 is approved with the name fluorbritholite-(Y).
Hormone replacement therapy: a survey of Ontario physicians' prescribing practices.

BACKGROUND Although much has been written about hormone replacement therapy (HRT), there are few clearcut recommendations on its use. The purpose of this study was to determine Ontario physicians' patterns of and reasons for prescribing HRT, their use of pretreatment investigations and their surveillance of HRT users, and to determine whether physicians' reported practice is consistent with existing recommendations. METHODS A self-administered questionnaire was mailed to a nonproportional stratified sample of 327 Ontario physicians (23.9% gynecologists, 76.1% general practitioners/family physicians [GP/FPs]). Outcome measures were ranking of reasons for prescribing HRT, nature of preliminary testing, regimens prescribed, duration of HRT and frequency of follow-up. RESULTS The response rate was 60.9% overall (70.9% of the gynecologists, 58.3% of the GP/FPs). Prevention of osteoporosis was reported by 97.4% as an important or very important reason for prescribing HRT; prevention of coronary artery disease was important or very important for 89.3%. When considering whether or not to prescribe HRT, 97.3% stated that breast cancer was an important or very important factor. When presented with hypothetical cases, 97.0% stated that they would prescribe combined estrogen-progestin for a symptomatic woman with an intact uterus; 13.6% stated that they would do so for a woman with no uterus. Most reported that they would prescribe HRT for 12 or more years (73.3%) and would follow up patients every 1 to 2 years (70.6%). INTERPRETATION Despite controversy about HRT in the published literature, the Ontario physicians surveyed reported similar reasons and patterns of prescribing, pretreatment investigations, and surveillance of postmenopausal women using HRT. These results suggest that Ontario physicians' knowledge about HRT is consistent with recommendations in the published literature.
Estimation of the number and size of motor units in intrinsic laryngeal muscles using morphometric methods

The number and size of motor units in the intrinsic laryngeal muscles were estimated by morphometric methods. Laryngeal muscles with their respective nerve branches were obtained from 64 fresh cadavers (32 older than 60 years, mean age 74 ± 9 years and 32 younger than 60 years, mean age 51 ± 8 years). Myelinated nerve fibers and the total number of muscle fibers were counted. Motor unit size was estimated by dividing the total number of muscle fibers by the total number of motor units in each case. The mean number of motor units ranged from 268 ± 1.3 (interarytenoid muscle) to 431 ± 1.6 (cricothyroid muscle). Thyroarytenoid and cricothyroid muscle presented the smallest (9.8 ± 0.2) and largest (20.5 ± 0.9) motor unit size, respectively, suggesting that thyroarytenoid muscle has a greater capacity to fine‐tune its total force compared with the other intrinsic laryngeal muscles. No differences in motor unit number or size were observed between the right and left sides or between younger and older subjects. It is suggested that synaptic rearrangements may occur at the level of the neuromuscular junction in the human larynx that may explain the age‐related changes in motor units reported by clinical methods. Clin. Anat. 21:301–306, 2008. © 2008 Wiley‐Liss, Inc.
Recursive estimation of images using non-Gaussian autoregressive models

We consider recursive estimation of images modeled by non-Gaussian autoregressive (AR) models and corrupted by spatially white Gaussian noise. The goal is to find a recursive algorithm to compute a near minimum mean square error (MMSE) estimate of each pixel of the scene using a fixed lookahead of D rows and D columns of the observations. Our method is based on a simple approximation that makes possible the development of a useful suboptimal nonlinear estimator. The algorithm is first developed for a non-Gaussian AR time-series and then generalized to two dimensions. In the process, we draw on the well-known reduced update Kalman filter (KF) technique of Woods and Radewan to circumvent computational load problems. Several examples demonstrate the non-Gaussian nature of residuals for AR image models and that our algorithm compares favorably with the Kalman filtering techniques in such cases.
Synthesising environmental and socio-economic sustainability models: a multi-level approach for advancing integrated sustainability research and practice

ABSTRACT Over the last decade, increasing research into sustainable business models has produced a number of prototypes that address various dimensions and levels of sustainability. What exists is a patchwork of certification and disconnected frameworks that are less than systematic and comprehensive. This article addresses this lack of integrated, holistic sustainability management research and practice guides by bringing together several salient and strategic sustainability management models. The authors then forward a synthesised, integrated environmental and socio-economic sustainability model that can be used by different types of entities, at different levels of human organisation, to identify, apply, assess, evaluate, and improve processes that advance sustainability values. This article concludes by suggesting future directions for modelling and applying the concepts and practices of multiple levels, systems elements, stages, structures, and cultures to advance sustainability management.
Formation of the Thalamocortical Projection Regulated Differentially by BDNF- and NT-3-Mediated Signaling

During development thalamocortical (TC) axons establish lamina-specific connections with cortical cells, and in later developmental stages TC projections are modified by activity-dependent processes. Recent studies have demonstrated that brain-derived neurotrophic factor and neurotrophin-3 are expressed in the cortex with distinct developmental time courses, and are involved not only in the formation of the TC projection but also in the subsequent refinement processes. Evidence further suggests that these actions of neurotrophins are achieved in cooperation with membrane-associated molecules expressed in cortical cells.
Endogenous Nitric Oxide Can Act as Beneficial or Deleterious in the Hypoxic Lung Depending on the Reoxygenation Time

Nitric oxide (NO) has been implicated in many pathophysiological situations in the lung, including hypoxia/reoxygenation. This work seeks to clarify the current controversy concerning the double protective/toxic role of endogenous NO under hypoxia/reoxygenation situations in the lung by using a nitric oxide synthase (NOS) inhibitor, in a novel approach to address the problems raised from assaults under such circumstances. A follow‐up study was conducted in Wistar rats submitted to hypoxia/reoxygenation (hypoxia for 30 min; reoxygenation of 0 h, 48 h, and 5 days), with or without prior treatment using the nonselective NOS inhibitor L‐NAME (1.5 mM, in drinking water). Lipid peroxidation, apoptosis level, protein nitration, in situ NOS activity and NO production (NOx) were analyzed. This is the first work to focus on the time‐course effects of L‐NAME in the adult rat lung submitted to hypoxia/reoxygenation. The results showed that after L‐NAME administration, in situ NOS activity was almost completely eliminated and consequently, NOx levels fell. Lipid peroxidation and the percentage of apoptotic cells rose at the earliest reoxygenation time (0 h), but decreased in the later period (48 h and 5 days). Also nitrated protein expression decreased at 48 h and 5 days posthypoxia. These results suggest that NOS‐derived NO exerts two different effects on lung hypoxia/reoxygenation injury depending on the reoxygenation time: NO has a beneficial role just after the hypoxic stimulus and a deleterious effect in the later reoxygenation times. Moreover, we propose that this dual role of NO depends directly on the producer NOS isoform. Anat Rec, 2010. © 2010 Wiley‐Liss, Inc.
Critical issues in donation after circulatory death

There is a major shortage of donor organs for transplantation. Organ donation after circulatory arrest (DCD: donation after circulatory death or cardiac arrest) makes an important contribution to the donor pool. This thesis provides insights into critical aspects of the DCD process and recommendations for optimising the process, from obtaining permission for donation to predicting and confirming the death. The perception of the families regarding the end-of-life care of intensive care patients is positively influenced by a donation procedure. To better utilise the potential for donors in Europe, recommendations are made in this thesis for implementing an ethically acceptable DCD programme. There should be a strict separation between the treatment team of a patient and the team that recommends the donation. The possibility of donation should be discussed as a rule with all dying patients who could be potential donors.