Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.

Electrophiles formed during metabolic activation of chemical carcinogens and reactive oxygen species generated from endogenous and exogenous sources play a significant role in carcinogenesis. Cancer chemoprevention by induction of phase 2 proteins to counteract the insults of these reactive intermediates has gained considerable attention. Nuclear factor E2 p45-related factor 2 (Nrf2), a bZIP transcription factor, plays a central role in the regulation (basal and or inducible expression) of phase 2 genes by binding to the "antioxidant response element" in their promoters. Identification of novel Nrf2-regulated genes is likely to provide insight into cellular defense systems against the toxicities of electrophiles and oxidants and may define effective targets for achieving cancer chemoprevention. Sulforaphane is a promising chemopreventive agent that exerts its effect by strong induction of phase 2 enzymes via activation of Nrf2. In the present study, a transcriptional profile of small intestine of wild-type (nrf2 +/+) and knock out (nrf2 -/-) mice treated with vehicle or sulforaphane (9 micromol/day for 1 week, p.o.) was generated using the Murine Genome U74Av2 oligonucleotide array (representing approximately 6000 well-characterized genes and nearly 6000 expressed sequence tags). Comparative analysis of gene expression changes between different treatment groups of wild-type and nrf2-deficient mice facilitated identification of numerous genes regulated by Nrf2 including previously reported Nrf2-regulated genes such as NAD(P)H:quinone reductase (NQO1), glutathione S-transferase (GST), gamma-glutamylcysteine synthetase (GCS), UDP-glucuronosyltransferases (UGT),epoxide hydrolase, as well as a number of new genes. Also identified were genes encoding for cellular NADPH regenerating enzymes (glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and malic enzyme), various xenobiotic metabolizing enzymes, antioxidants (glutathione peroxidase, glutathione reductase, ferritin, and haptaglobin), and biosynthetic enzymes of the glutathione and glucuronidation conjugation pathways. The data were validated by Northern blot analysis and enzyme assays of selected genes. This investigation expands the horizon of Nrf2-regulated genes, highlights the cross-talk between various metabolic pathways, and divulges the pivotal role played by Nrf2 in regulating cellular defenses against carcinogens and other toxins.
A wearable respiration monitoring system based on digital respiratory inductive plethysmography

In this paper we present a wearable device for continuous monitoring of respiration signal and the associated algorithm for signal evaluations. The device took advantages of a proven respiratory inductive plethysmograph (RIP) technology and a wireless body sensor networks (BSN) development platform. The textile RIP sensor was integrated into a suit that could be comfortably worn around thorax or abdomen for monitoring respiration during sleep. A smart signal processing algorithm was implemented for extracting the dynamic respiration rate. The results of in-situ experiments from ten healthy subjects suggested that our system worked as intended. Due to the high reliability and low cost of our system it is believed to meet the future demands on home-based monitoring and diagnosis of sleep disorder-related diseases.
Formalizing ETL Jobs for Incremental Loading of Data Warehouses

Extract-transform-load (ETL) tools are primarily designed for data ware- house loading, i.e. to perform physical data integration. When the operational data sources happen to change, the data warehouse gets stale. To ensure data timeliness, the data warehouse is refreshed on a periodical basis. The naive approach of simply reloading the data warehouse is obviously inefficient. Typically, only a small fraction of source data is changed during loading cycles. It is therefore desirable to capture these changes at the operational data sources and refresh the data warehouse incre- mentally. This approach is known as incremental loading. Dedicated ETL jobs are required to perform incremental loading. We are not aware of any ETL tool that helps to automate this task. In fact, incremental load jobs are handcrafted by ETL program- mers so far. The development is thus costly and error-prone. In this paper we present an approach to the automated derivation of incremental load jobs based on equational reasoning. We review existing Change Data Capture techniques and discuss limitations of different approaches. We further review existing loading facilities for data warehouse refreshment. We then provide transformation rules for the derivation of incremental load jobs. We stress that the derived jobs rely on existing Change Data Capture techniques, existing loading facilities, and existing ETL execution platforms.
Radiographic and histological evaluation of bisphosphonate alendronate and metotrexate effects on rat mandibles inoculated with Walker 256 carcinosarcoma.

PURPOSE To investigate the effects of bisphosphosnate alendronate (ALD) and metotrexate (MTX) on an experimental model of Walker 256 carcinosarcoma developed in the oral cavity of rats. METHODS Walker 256 carcinosarcoma cell suspension (0,1 mL) containing 10(6) cell/mL was implanted in the alveoli of the first and second molars. The animals were divided and treated with saline, MTX, ALD, and MTX plus ALD. Later, the animals were sacrificed, the tumors were measured and the mandibles were removed for radiographic and histological analysis. RESULTS In the control group, the radiographic images demonstrated radioluscency with poorly defined borders, and the microscopic examination revealed tumor infiltration into the peripheral and central regions of the bone. Areas of necrosis were commonly seen. In the treated groups with ALD, associated or not with MTX, the radiographic analysis revealed circumscribed tumor-induced osteolysis and various degrees of radiotransparence; while, histologically, preserved bone trabeculae with osteoid formation was observed among malignant cells. CONCLUSION The bisphosphonate alendronate exherted an osteoprotective effect and induced bone neoformation on the Walker 256 carcinosarcoma inoculated in rat mandibles. The combination of metotrexate with bisphosphonate alendronate is more successful than treatment with the agents alone in controlling the growth of neoplastic cells and in stimulating reactive new bone. Therefore, this may be an alternative treatment to malignant lesions of maxillaries with osteolysis.
Controllable load sharing for soft adhesive interfaces on three-dimensional surfaces

Significance In transfer printing, robotics, and precision manufacturing, adhesion-controlled grasping of complex 3D surfaces is very challenging because the adhesive must be soft enough to enable intimate contact under light pressure but stiff enough to support high load and fracture strength. We address this dilemma by replacing the adhesive with a pressurized microfiber array that enables independent control of 3D conformability and bond strength. This architecture exhibits enhanced and robust adhesion on various sizes of 3D and deformable surfaces. In contrast to other microfiber adhesives, it has the area scalability of the natural gecko footpad. These features suggest that the proposed soft-gripping system can outperform conventional adhesive systems for a broad range of surface shapes and length scales. For adhering to three-dimensional (3D) surfaces or objects, current adhesion systems are limited by a fundamental trade-off between 3D surface conformability and high adhesion strength. This limitation arises from the need for a soft, mechanically compliant interface, which enables conformability to nonflat and irregularly shaped surfaces but significantly reduces the interfacial fracture strength. In this work, we overcome this trade-off with an adhesion-based soft-gripping system that exhibits enhanced fracture strength without sacrificing conformability to nonplanar 3D surfaces. Composed of a gecko-inspired elastomeric microfibrillar adhesive membrane supported by a pressure-controlled deformable gripper body, the proposed soft-gripping system controls the bonding strength by changing its internal pressure and exploiting the mechanics of interfacial equal load sharing. The soft adhesion system can use up to ∼26% of the maximum adhesion of the fibrillar membrane, which is 14× higher than the adhering membrane without load sharing. Our proposed load-sharing method suggests a paradigm for soft adhesion-based gripping and transfer-printing systems that achieves area scaling similar to that of a natural gecko footpad.
A real time system for model-based interpretation of the dynamics of facial expressions

Our system runs at 10 fps on a 2.0 GHz processor and an image resolution of 640times480 pixels. High quality objective functions that are learned from annotated example images ensure both an accurate and fast computation of the model parameters. Our demonstrator for facial expression estimation has been presented at several events with political audience and on TV. However, the approach of robust face models fitting, forms the basis of various more applications such as gaze detection or gender estimation. The drawback of our approach is that the data base from which the objective function is learned needs to cover all aspects of face properties. If, for instance, the database did not contain images of bearded men the objective function will fail when confronted with such an image. Furthermore, the data base has to be manually annotated. Although no expert knowledge is required, this task requires a considerable amount of time. An online fitting demonstration is available.
Bacterial community patterns and thermal analyses of composts of various origins

During composting, the degradation of organic waste is accompanied and driven by a succession of microbial populations exhibiting a broad range of functional capabilities. Detailed inventories of the microbial communities in mature compost, however, are not available. Mature composts, originating from biowaste as well as sewage sludge and anaerobic sludge, were studied by denaturing gradient gel electrophoresis-fingerprints after polymerase chain reaction (PCR) amplification of the 16S rRNA genes using three different universal primer pairs, as well as by differential scanning calorimetry and thermogravimetry. The composts of different origin had different bacterial communities. The influence of different 16S rDNA primer sets on the same batches of compost DNA was evaluated. The clearest separation of different compost types was obtained by using the PCR primer pair 338f + 518r which is suggested for future applications. Communities from the different biowaste compost samples clustered together and could be separated from sewage sludge communities indicating the establishment of different microbial consortia. A similar differentiation of composts was found with the thermogavimetric analyses. It may thus be concluded that the resulting humus quality is closely linked to the microbial communities involved.
Evaluación de la confiabilidad y la validez de un cuestionario breve de autoinforme para el diagnóstico de la fobia social

El objetivo fue evaluar la confiabilidad y la validez de un cuestionario breve de autoinforme dirigido al diagnostico de la fobia social, basado en los criterios diagnosticos de la Asociacion Psiquiatrica Americana (2002), para lo cual se conto con una muestra incidental de 532 estudiantes vinculados a cuatro universidades privadas y una publica de la ciudad de Bogota (Colombia), entre 15 y 42 anos de edad (media de 21.1 anos) y todos los estratos socioeconomicos. La confiabilidad del instrumento se evaluo a traves de la tecnica test-retest y se valoro su validez de contenido y su validez de constructo. El analisis estadistico de la confiabilidad realizado con 250 comparaciones (Spearman), arrojo una correlacion positiva altamente significativa entre las puntuaciones test-retest, mientras que los analisis de la validez de constructo (Chi Cuadrado, Tau-b de Kendall y Spearman) mostraron correlaciones positivas altamente significativas entre el diagnostico de fobia social y la obtencion de una puntuacion considerada alta en los tres instrumentos mencionados.
The effects of ageing and divided attention on the self-reference effect in emotional memory: Spontaneous or effortful mnemonic benefits?

The self-reference effect (SRE) is a powerful memory advantage associated with encoding in reference to the self (e.g., Rogers, Kuiper, & Kirker, 1977). To explore whether this mnemonic benefit occurs spontaneously, the current study assessed how ageing and divided attention affect the magnitude of the SRE in emotional memory (i.e., memory for emotional stimuli). The sample included a young Full Attention group (young-FA), a young Divided Attention group (young-DA), and an older adult group. The division of attention was manipulated at encoding where participants incidentally studied positive, negative, and neutral trait adjectives in either a self-reference (i.e., rating how well each word describes themselves) or an other-reference condition (i.e., rating how well each word describes another person). Memory for these words was assessed with both recall and recognition tasks. The results from both tasks demonstrated equivalent SRE for all three groups across emotional valence categories of stimuli, suggesting that the SRE is a spontaneous, effortless, and robust effect in memory.
Financial Flows and the International Monetary System

We review the findings of the literature on the benefits of international financial flows and find that they are quantitatively elusive. We then present evidence on the existence of a global cycle in gross cross border flows, asset prices and leverage and discuss its impact on monetary policy autonomy across different exchange rate regimes. We focus in particular on the effect of US monetary policy shocks on the UK's financial conditions.
Obstacle detection, tracking and avoidance for a teleoperated UAV

In this paper, we present a collision-free indoor navigation algorithm for teleoperated multirotor Unmanned Aerial Vehicles (UAVs). Assuming an obstacle rich environment, the algorithm keeps track of detected obstacles in the local surroundings of the robot. The detection part of the algorithm is based on measurements from an RGB-D camera and a Bin-Occupancy filter capable of tracking an unspecified number of targets. We use the estimate of the robot's velocity to update the obstacles state when they leave the direct field of view of the sensor. The avoidance part of the algorithm is based on the Model Predictive Control approach. By predicting the possible future obstacles states, it filters the operator commands to prevent collisions. The method is validated on a platform equipped with its own computational unit, which makes it self-sufficient in terms of external CPUs.
p120-catenin in cancer – mechanisms, models and opportunities for intervention

Summary The epithelial adherens junction is an E-cadherin-based complex that controls tissue integrity and is stabilized at the plasma membrane by p120-catenin (p120, also known as CTNND1). Mutational and epigenetic inactivation of E-cadherin has been strongly implicated in the development and progression of cancer. In this setting, p120 translocates to the cytosol where it exerts oncogenic properties through aberrant regulation of Rho GTPases, growth factor receptor signaling and derepression of Kaiso (also known as ZBTB33) target genes. In contrast, indirect inactivation of the adherens junction through conditional knockout of p120 in mice was recently linked to tumor formation, indicating that p120 can also function as a tumor suppressor. Supporting these opposing functions are findings in human cancer, which show that either loss or cytoplasmic localization of p120 is a common feature in the progression of several types of carcinoma. Underlying this dual biological phenomenon might be the context-dependent regulation of Rho GTPases in the cytosol and the derepression of Kaiso target genes. Here, we discuss past and present findings that implicate p120 in the regulation of cancer progression and highlight opportunities for clinical intervention.
A Higher-Order Calculus of Computational Fields

The complexity of large-scale distributed systems, particularly when deployed in physical space, calls for new mechanisms to address composability and reusability of collective adaptive behaviour. Computational fields have been proposed as an effective abstraction to fill the gap between the macro-level of such systems (specifying a system’s collective behaviour) and the micro-level (individual devices’ actions of computation and interaction to implement that collective specification), thereby providing a basis to better facilitate the engineering of collective APIs and complex systems at higher levels of abstraction. This article proposes a full formal foundation for field computations, in terms of a core (higher-order) calculus of computational fields containing a few key syntactic constructs, and equipped with typing, denotational and operational semantics. Critically, this allows formal establishment of a link between the micro- and macro-levels of collective adaptive systems by a result of computational adequacy and abstraction for the (aggregate) denotational semantics with respect to the (per-device) operational semantics.
mPer1 and mPer2 Are Essential for Normal Resetting of the Circadian Clock

Mammalian Per1 and Per2 genes are involved in the mechanism of the circadian clock and are inducible by light. Alight pulse can evoke a change in the onset of wheel-running activity in mice by shifting the onset of activity to earlier times (phase advance) or later times (phase delays) thereby advancing or delaying the clock (clock resetting). To assess the role of mouse Per (mPer) genes in circadian clock resetting, mice carrying mutant mPer1 or mPer2 genes were tested for responses to a light pulse at ZT 14 and ZT 22, respectively. The authors found that mPer1 mutants did not advance and mPer2 mutants did not delay the clock. They conclude that the mammalian Per genes are not only light-responsive components of the circadian oscillator but also are involved in resetting of the circadian clock.
Proposed electronic calculator ; reprinted in ( Copeland 2005 ) Universal Turing Machine

The implications of lossless models have been far-reaching and pervasive. After years of appropriate research into digital-to-analog converters , we prove the refinement of compilers, which embodies the natural principles of operating systems. Our focus here is not on whether web browsers and evolutionary programming can collude to solve this problem, but rather on presenting a framework for efficient modalities (Solemp-neCadet).
Association between insulin resistance and preeclampsia in obese non-diabetic women receiving metformin

Objectives To examine whether the reduced incidence of preeclampsia in non-diabetic obese pregnant women treated with metformin is mediated by changes in insulin resistance. Methods This was a secondary analysis of obese pregnant women in a randomised trial (MOP trial). Fasting plasma glucose and insulin were measured in 384 of the 400 women who participated in the MOP trial. Homeostasis model assessment of insulin resistance (HOMA-IR) was compared in the metformin and placebo groups and in those that developed preeclampsia versus those that did not develop preeclampsia. Results At 28 weeks, median HOMA-IR was significantly lower in the metformin group. Logistic regression analysis demonstrated that there was a significant contribution in the prediction of preeclampsia from maternal history of chronic hypertension and gestational weight gain, but not HOMA-IR either at randomisation (p = 0.514) or at 28 weeks (p = 0.643). Conclusions Reduced incidence of preeclampsia in non-diabetic obese pregnant women treated with metformin is unlikely to be due to changes in insulin resistance.
Portraying Professional Development in Preservice Teacher Education: can portfolios do the job?

Abstract Using a form of collaborative action research among university faculty, teacher associates in schools and preservice teachers, the efficacy of using professional portfolios to enable the participants to document, understand and assess the professional growth of student teachers was explored. In this longitudinal study, 15 student teachers were followed through two practica and one internship during the course of 3 years. Interview data was examined to discern what themes evolved when student teachers were deeply engaged in self‐evaluation through portfolio development. Three categories of themes were identified: those that emerged early in students’ practicum experiences and dissipated, those that emerged and remained throughout the study, and those that were manifested later in the study. The thematic structure and the processes that the themes represent reveal insights into the nature of teaching and learning to teach, and they demonstrate the efficacy of the portfolio process in facilitating a.
Cluster crystals in confinement

A large class of fluids of particles interacting via ultrasoft, repulsive pair potentials crystallize into cluster crystals. Here, we employ density functional theory and computer simulations to study the behavior of a system of particles that repel each other with a exp(−r8)-potential [A. J. Moreno and C. N. Likos, Phys. Rev. Lett. , 2007, 99, 107801] under planar confinement. We compare the behavior for purely repulsive to that for attractive slit walls. In particular, we present the phase diagram and we show that for repulsive walls the system freezes from the middle, whereas for attractive ones crystallization sets in at the walls and proceeds to the middle. For large wall-wall-separations we find continuous growth of a fluid or crystalline layer on the wall, depending on the wall-particle interaction, which is interrupted by capillary melting or freezing close to the bulk crystallization transition. An asymptotic scaling analysis of the width of the liquid or crystalline films growing at the walls indicate complete wetting in both cases. PACS numbers: 64.70. Dv, 82.30. Nr, 61.20. Ja, 82.70. Dd
Adaptive Contour Features in oriented granular space for human detection and segmentation

In this paper, a novel feature named adaptive contour feature (ACF) is proposed for human detection and segmentation. This feature consists of a chain of a number of granules in oriented granular space (OGS) that is learnt via the AdaBoost algorithm. Three operations are defined on the OGS to mine object contour feature and feature co-occurrences automatically. A heuristic learning algorithm is proposed to generate an ACF that at the same time define a weak classifier for human detection or segmentation. Experiments on two open datasets show that the ACF outperform several well-known existing features due to its stronger discriminative power rooted in the nature of its flexibility and adaptability to describe an object contour element.