Miracle-dz/UniFAR-FTUs huggingface dataset:
Is local adaptation in Mimulus guttatus caused by trade‐offs at individual loci?

Local adaptation is considered to be the result of fitness trade‐offs for particular phenotypes across different habitats. However, it is unclear whether such phenotypic trade‐offs exist at the level of individual genetic loci. Local adaptation could arise from trade‐offs of alternative alleles at individual loci or by complementary sets of loci with different fitness effects of alleles in one habitat but selective neutrality in the alternative habitat. To evaluate the genome‐wide basis of local adaptation, we performed a field‐based quantitative trait locus (QTL) mapping experiment on recombinant inbred lines (RILs) created from coastal perennial and inland annual races of the yellow monkeyflower (Mimulus guttatus) grown reciprocally in native parental habitats. Overall, we detected 19 QTLs affecting one or more of 16 traits measured in two environments, most of small effect. We identified 15 additional QTL effects at two previously identified candidate QTLs [DIVERGENCE (DIV)]. Significant QTL by environment interactions were detected at the DIV loci, which was largely attributable to genotypic differences at a single field site. We found no detectable evidence for trade‐offs for any one component of fitness, although DIV2 showed a trade‐off involving different fitness traits between sites, suggesting that local adaptation is largely controlled by non‐overlapping loci. This is surprising for an outcrosser, implying that reduced gene flow prevents the evolution of individuals adapted to multiple environments. We also determined that native genotypes were not uniformly adaptive, possibly reflecting fixed mutational load in one of the populations.
The Cloud@Home Resource Management System

Cloud is strongly emerging in the ICT world as the distributed computing paradigm able to raise the level of abstraction of physical resources toward a "user-centric" perspective. In this challenging scenario, we propose a new form of computing mixing Cloud and volunteer paradigms' aims and goals into Cloud@Home. In particular, this work focuses on the Cloud@Home resource management issues. In order to deal with the dynamics of the overall infrastructure, where resources asynchronously join and leave the system, we propose a solution based on autonomic and self-adapting algorithms, structuring all the available resources into a hierarchical cluster. In this paper, we first specify the architecture of the Cloud@Home resource management system and then we detail the algorithms and the mechanisms that allow to elastically manage the hierarchical cluster-based infrastructure.
Ethical Issues in Cross-Cultural Neuropsychology

Clinical neuropsychologists who assess patients from diverse cultural and linguistic backgrounds face unique ethical challenges. In this article, we address 4 critical questions relevant to ethics of cross-cultural neuropsychology: (a) Should culture or race be considered in neuropsychological testing? (b) Should race- and ethnicity-specific normative data be used in the clinical neuropsychological evaluation? (c) Who is competent to design and translate tests for ethnic minority groups and non-English speakers and who is competent to administer and interpret them? and (d) Are neuropsychology training programs adequately preparing clinicians to be competent in the assessment of cross-cultural groups? The overall aims of the article are to highlight the complexity of these clinical and ethical issues, to provide comprehensive and balanced information to help guide clinician choices, and to stimulate future research in this area.
Intraocular Retinal Transplantation: A Review

This review covers intraocular transplantation of retinal tissue. This has importance both for theoretical understanding of retinal and neural development and for possible future clinical application. Transplantation sites have ranged from the anterior chamber through the retina to the subretinal space. Transplanted tissue has ranged from whole retina to specific retinal layers or specific types of retinal cells. Both within-species and inter-species transplants have been performed, and donor age has ranged from embryonic to adult. The ability of transplanted tissue to be accepted and to differentiate in host eyes has been studied. The conditions under which successful transplants are obtained, host-graft interactions, and transplantation methodologies have been explored. Morphological, and to a small extent, also functional characteristics of the transplants have been studied.
Community energy: Entanglements of community, state, and private sector

The decarbonisation of energy systems is leading to a reconfiguration of the geographies of energy. One example is the emergence of community energy, which has become a popular object of study for geographers. Although widely acknowledged to be a contested, capacious and flexible term, ‘community energy’ is commonly presented as singular, bounded and localised. In this paper, we challenge this conception of community energy by considering evidence about the role and influence of three categories of actors: community; state; and private sector. We demonstrate how community energy projects are unavoidably entangled with a diversity of actors and institutions operating at and across multiple scales. We therefore argue that community energy is enabled and constituted by trans-scalar assemblages of overlapping actors, which demands multi-sectoral participation and coordination. We point to the need for further academic attention on the boundaries between these actors to better understand the role of different intermediary practices and relationships in facilitating the development of decentralised energy systems with just outcomes.
Immunopotentiation of Trivalent Influenza Vaccine When Given with VAX102, a Recombinant Influenza M2e Vaccine Fused to the TLR5 Ligand Flagellin

Background Currently controversy exists about the immunogenicity of seasonal trivalent influenza vaccine in certain populations, especially the elderly. STF2.4×M2e (VAX102) is a recombinant fusion protein that links four copies of the ectodomain of influenza virus matrix protein 2 (M2e) antigen to Salmonella typhimurium flagellin, a TLR5 ligand. The objectives of this study were to assess the feasibility of giving VAX102 and TIV in combination in an effort to achieve greater immunogenicity and to provide cross-protection. Methodology/Principal Findings Eighty healthy subjects, 18-49 years old, were enrolled in May and June 2009 in a double-blind, randomized, controlled trial at two clinical sites. Subjects were randomized to receive either TIV + VAX102 or TIV + placebo. Both arms tolerated the vaccines. Pain at the injection site was more severe with TIV + VAX102. Two weeks after immunization the HAI responses to the H1 and H3 antigens of TIV were higher in those that received TIV + VAX102 than in TIV + placebo (309 vs 200 and 269 vs 185, respectively), although statistically non-significant. There was no difference in the HAI of the B antigen. In the TIV + VAX102 arm, the geometric mean M2e antibody concentration was 0.5 µg/ml and 73% seroconverted. Conclusions/Significance The combination of TIV + VAX102 has the potential to increase the immune response to the influenza A components of TIV and to provide M2e immunity which may protect against influenza A strains not contained in seasonal TIV. Trial Registration ClinicalTrials.gov NCT00921973
Review: psychosocial issues in pediatric inflammatory bowel disease.

OBJECTIVE To review and critically evaluate research on psychosocial issues in pediatric inflammatory bowel disease (IBD) and to provide recommendations for future research. METHODS A literature search was conducted using the Medline and PsychInfo computerized databases as well as the bibliographies of relevant articles. RESULTS Most of the existing research has compared children with IBD to healthy populations and other illness populations. Compared to healthy children, children with IBD may be at greater risk for difficulties in behavioral and emotional functioning as well as in family and parent functioning, but all such functioning appears similar to that found in other illness populations. It is unclear if the increased risk reaches clinical significance and what role the severity of the disease plays in adjustment. CONCLUSIONS Future research should use a developmental perspective to investigate the process of adaptation to IBD, risk factors of poor adjustment, and the role of psychosocial factors in health outcomes in pediatric IBD.
HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration

What drives the gradual degeneration of dopamine neurons in Parkinson's disease (PD), the second most common neurodegenerative disease, remains elusive. Here, we demonstrated, for the first time, that persistent neuroinflammation was indispensible for such a neurodegenerative process. 1-Methyl-4-phenylpyridinium, lipopolysaccharide (LPS), and rotenone, three toxins often used to create PD models, produced acute but nonprogressive neurotoxicity in neuron-enriched cultures. In the presence of microglia (brain immune cells), these toxins induced progressive dopaminergic neurodegeneration. More importantly, such neurodegeneration was prevented by removing activated microglia. Collectively, chronic neuroinflammation may be a driving force of progressive dopaminergic neurodegeneration. Conversely, ongoing neurodegeneration sustained microglial activation. Microglial activation persisted only in the presence of neuronal damage in LPS-treated neuron–glia cultures but not in LPS-treated mixed-glia cultures. Thus, activated microglia and damaged neurons formed a vicious cycle mediating chronic, progressive neurodegeneration. Mechanistic studies indicated that HMGB1 (high-mobility group box 1), released from inflamed microglia and/or degenerating neurons, bound to microglial Mac1 (macrophage antigen complex 1) and activated nuclear factor-κB pathway and NADPH oxidase to stimulate production of multiple inflammatory and neurotoxic factors. The treatment of microglia with HMGB1 led to membrane translocation of p47phox (a cytosolic subunit of NADPH oxidase) and consequent superoxide release, which required the presence of Mac1. Neutralization of HMGB1 and genetic ablation of Mac1 and gp91phox (the catalytic submit of NADPH oxidase) blocked the progressive neurodegeneration. Our findings indicated that HMGB1–Mac1–NADPH oxidase signaling axis bridged chronic neuroinflammation and progressive dopaminergic neurodegeneration, thus identifying a mechanistic basis for chronic PD progression.
Design of a MEMS-Based Flight Information Measurement Unit For UAV Application

Department of Aerospace Engineering, Tamkang University, Danshui, Taiwan. Corresponding Author: Jaw-Kuen Shiau __________________________________________________________________________________________ Abstract This paper summarizes the development of a MEMS-based flight information system. It includes an inertial and air data measurement unit and an electronic compass unit. The inertial and air data measurement unit provides the capability for three-axis accelerations, three-axis angular rates, airspeed, altitude, temperature, and angle of attack measurements. The compass system is used to measure the magnitude of the external magnetic fields. A Microchip PIC micro-controller is used in each measuring unit to perform data acquisition and deduction and to transfer the results to the host system for further analysis and processing. The inertial and air data measurement unit uses the RS232 serial port to interface with the host system while the compass unit uses the USB bus. The performance of the designed system is evaluated using an in-house designed four-axis motion platform. A specially designed wireless transmission system is also developed and integrated into the test system to improve the efficiency and flexibility of the test system A hardware-software integrated, function tested real system is accomplished in this design. __________________________________________________________________________________________
Subband merging in cosine-modulated filter banks

Recently, a new method for constructing nonuniform modulated lapped transforms (MLTs) was introduced, by combining subband filters of a uniform MLT. The design, however, was restricted to combining two or four subband filters only, and no systematic design procedure was given. In this letter, we propose an extension to the above-mentioned method that allows arbitrary numbers of subbands to be combined in a systematic way. We investigate the general case of combining filters in arbitrary cosine-modulated filter banks, and give conditions on how to combine the constituent filters such that the resulting nonuniform filter banks have suitable frequency responses.
MicroRNAs Induced During Adipogenesis that Accelerate Fat Cell Development Are Downregulated in Obesity

OBJECTIVE We investigated the regulation and involvement of microRNAs (miRNAs) in fat cell development and obesity. RESEARCH DESIGN AND METHODS Using miRNA microarrays, we profiled the expression of >370 miRNAs during adipogenesis of preadipocyte 3T3-L1 cells and adipocytes from leptin deficient ob/ob and diet-induced obese mice. Changes in key miRNAs were validated by RT-PCR. We further assessed the contribution of the chronic inflammatory environment in obese adipose tissue to the dysregulated miRNA expression by tumor necrosis factor (TNF)-α treatment of adipocytes. We functionally characterized two adipocyte-enriched miRNAs, miR-103 and miR-143, by a gain-of-function approach. RESULTS Similar miRNAs were differentially regulated during in vitro and in vivo adipogenesis. Importantly, miRNAs that were induced during adipogenesis were downregulated in adipocytes from both types of obese mice and vice versa. These changes are likely associated with the chronic inflammatory environment, since they were mimicked by TNF-α treatment of differentiated adipocytes. Ectopic expression of miR-103 or miR-143 in preadipocytes accelerated adipogenesis, as measured both by the upregulation of many adipogenesis markers and by an increase in triglyceride accumulation at an early stage of adipogenesis. CONCLUSIONS Our results provide the first experimental evidence for miR-103 function in adipose biology. The remarkable inverse regulatory pattern for many miRNAs during adipogenesis and obesity has important implications for understanding adipose tissue dysfunction in obese mice and humans and the link between chronic inflammation and obesity with insulin resistance.
The role of developing country multinationals in the acquisition of industrial technology in Nigeria: a pilot study

The growing presence of multinationals from developing countries (DC MNE''s) has drawn some criticism regarding their ability to transfer technology. This paper seeks to examine whether, in the case of Nigeria, such MNE''s utilise similar technology to that of Nigerian firms, and the implications for government policy on achieving technology transfer. Although tentative, the findings suggest that DC MNE''s in Nigeria do not tend to acquire technology primarily from their home country, and suggests that although tangible technology that is transferred is similar to that directly acquired by domestic firms, there is nonetheless a difference in the nature in the intangible technology between the two groups.
Research Statement Adam Bargteil

While exploding trucks and collapsing buildings are rare occurrences in everyday life, they are frequently depicted in films, video games, and training simulations. Filming such effects in the real world can be dangerous and obtaining a specific outcome is often difficult. Consequently, such effects are increasingly generated through physical simulations where initial conditions and parameters can be tuned to produce the desired effect. My research has focused on developing tools that allow artists to create high-quality, realistic, visually-detailed animations of complex materials for applications in computer graphics.
Probing dark energy with steerable wavelets through correlation of WMAP and NVSS local morphological measures

Using local morphological measures on the sphere defined through a steerable wavelet analysis, we examine the three-year WMAP and the NVSS data for correlation induced by the integrated Sachs-Wolfe (ISW) effect. The steerable wavelet constructed from the second derivative of a Gaussian allows one to define three local morphological measures, namely the signed- intensity, orientation and elongation of local features. Detections of correlation between the WMAP and NVSS data are made with each of these morphological measures. The most significant detection is obtained in the correlation of the signed-intensity of local features at a significance of 99.9%. By inspecting signed-intensity sky maps, it is possible for the first time to see the correlation between the WMAP and NVSS data by eye. Foreground contamination and instrumental systematics in the WMAP data are ruled out as the source of all significant detections of correlation. Our results provide new insight on the ISW effect by probing the morphological nature of the correlation induced between the cosmic microwave background and large scale structure of the Universe. Given the current constraints on the flatness of the Universe, our detection of the ISW effect again provides direct and independent evidence for dark energy. Moreover, this new morphological analysis may be used in future to help us to better understand the nature of dark energy.
Changes in protein function underlie the disease spectrum in patients with CHIP mutations

Monogenetic disorders that cause cerebellar ataxia are characterized by defects in gait and atrophy of the cerebellum; however, patients often suffer from a spectrum of disease, complicating treatment options. Spinocerebellar ataxia autosomal recessive 16 (SCAR16) is caused by coding mutations in STUB1, a gene that encodes the multifunctional enzyme CHIP (C terminus of HSC70-interacting protein). The disease spectrum of SCAR16 includes a varying age of disease onset, cognitive dysfunction, increased tendon reflex, and hypogonadism. Although SCAR16 mutations span the multiple functional domains of CHIP, it is unclear whether the location of the mutation and the change in the biochemical properties of CHIP contributes to the clinical spectrum of SCAR16. In this study, we examined relationships between the clinical phenotypes of SCAR16 patients and the changes in biophysical, biochemical, and functional properties of the corresponding mutated protein. We found that the severity of ataxia did not correlate with age of onset; however, cognitive dysfunction, increased tendon reflex, and ancestry were able to predict 54% of the variation in ataxia severity. We further identified domain-specific relationships between biochemical changes in CHIP and clinical phenotypes and specific biochemical activities that associate selectively with either increased tendon reflex or cognitive dysfunction, suggesting that specific changes to CHIP–HSC70 dynamics contribute to the clinical spectrum of SCAR16. Finally, linear models of SCAR16 as a function of the biochemical properties of CHIP support the concept that further inhibiting mutant CHIP activity lessens disease severity and may be useful in the design of patient-specific targeted approaches to treat SCAR16.
Grabrics: A Foldable Two-Dimensional Textile Input Controller

Textile interfaces can be ubiquitously integrated into the fabrics that already surround us. So far, existing interfaces transfer concepts, such as buttons and sliders, to the textile domain without leveraging the affordances and qualities of fabric. This paper presents Grabrics, a two-dimensional textile sensor that is manipulated by grabbing a fold and moving it between your fingers. Grabrics can be integrated invisibly into everyday clothing or into textile objects, like a living room sofa, while minimizing accidental activation. We describe the construction and the fold-based interaction technique of our Grabrics sensor. A preliminary study shows that Grabrics can be folded and manipulated from any arbitrary position, and it can detect 2D stroke gestures.
Distribution and direct radiative forcing of carbonaceous and sulfate aerosols in an interactive size-resolving aerosol-climate model

[1] A multimode, two-moment aerosol model has been incorporated in the NCAR CAM3 to develop an interactive aerosol–climate model and to study the impact of anthropogenic aerosols on the global climate system. Currently, seven aerosol modes, namely three for external sulfate and one each for external black carbon (BC), external organic carbon (OC), sulfate/BC mixture (MBS; with BC core coated by sulfate shell), and sulfate/OC mixture (MOS; a uniform mixture of OC and sulfate) are included in the model. Both mass and number concentrations of each aerosol mode, as well as the mass of carbonaceous species in the mixed modes, are predicted by the model so that the chemical, physical, and radiative processes of various aerosols can be formulated depending on aerosol’s size, chemical composition, and mixing state. Comparisons of modeled surface and vertical aerosol concentrations, as well as the optical depth of aerosols with available observations and previous model estimates, are in general agreement. However, some discrepancies do exist, likely caused by the coarse model resolution or the constant rates of anthropogenic emissions used to test the model. Comparing to the widely used mass-only method with prescribed geometric size of particles (one-moment scheme), the use of prognostic size distributions of aerosols based on a two-moment scheme in our model leads to a significant reduction in optical depth and thus the radiative forcing at the top of the atmosphere (TOA) of particularly external sulfate aerosols. The inclusion of two types of mixed aerosols alters the mass partitioning of carbonaceous and sulfate aerosol constituents: about 35.5%, 48.5%, and 32.2% of BC, OC, and sulfate mass, respectively, are found in the mixed aerosols. This also brings in competing effects in aerosol radiative forcing including a reduction in atmospheric abundance of BC and OC due to the shorter lifetime of internal mixtures (cooling), a mass loss of external sulfate to mixtures (warming), and an enhancement in atmospheric heating per BC mass due to the stronger absorption extinction of the MBS than external BC (warming). The combined result of including a prognostic size distribution and the mixed aerosols in the model is a much smaller total negative TOA forcing (� 0.12 W m �2 ) of all carbonaceous and sulfate aerosol compounds compared to the cases using one-moment scheme either excluding or including internal mixtures (� 0.42 and � 0.71 W m �2 , respectively). In addition, the global mean all-sky TOA direct forcing of aerosols is significantly more positive than the clear-sky value due to the existence of low clouds beneath the absorbing (external BC and MBS) aerosol layer, particularly over a dark surface. An emission reduction of about 44% for BC and 38% of primary OC is found to effectively change the TOA radiative forcing of the entire aerosol family by � 0.14 W m �2 for clear-sky and � 0.29 W m �2 for
Efficient estimation in the bivariate censoring model and repairing NPMLE

The NPMLE in the bivariate censoring model is not consistent. The problem is caused by the singly censored observations. In this paper we prove that the NPMLE based on interval censoring the singly censored observations is ecient for this reduced data and moreover if we let the width of the interval converge to zero slowly enough, then the NPMLE is also ecient for the original data. We are able to determine a lower bound for the rate at which the bandwidth should converge to zero. The eciency proof uses the general identity which holds for NPMLE of a linear parameter in convex models as proved in van der Laan (1993a).