Miracle-dz/UniFAR-FTUs huggingface dataset:
Fiber laser polarization tuning using a Bragg grating in a Hi-Bi fiber

Single- and dual-wavelength tunable lasing (around 1552 nm) has been obtained in an Er-doped low-Bi fiber laser with a Bragg grating mirror in a Hi-Bi fiber. Equal output powers for both laser lines and spectral spacing of up to 0.26 mm, larger than the original spacing between the resonance peaks of the grating (0.2 nm), can be easily achieved by employing a polarization controller inside of the laser cavity.
Dietary Corn Oil Promotes Colon Cancer by Inhibiting Mitochondria-Dependent Apoptosis in Azoxymethane-Treated Rats

How dietary corn oil is involved in colon carcinogenesis and cancer development is poorly understood. The aim of this study was to investigate whether long-term dietary corn oil promotes colon cancer by inhibiting the tumor suppressor gene p53-mediated mitochondria-dependent apoptosis in azoxymethane (AOM)-treated rats. Male Sprague-Dawley rats were injected with AOM or with saline and fed on a basal diet or basal diet supplemented with 10% corn oil for 48 weeks. Colonic aberrant crypt foci (ACF) and tumors, including adenomas and carcinomas, were examined. Colonic apoptosis and cell proliferation were evaluated. Wild type (wt) p53 was analyzed using reverse transcription–polymerase chain reaction (RT-PCR) and Western blotting. In addition, Bcl-2, Bcl-xL, Bax, and Bak localized in the mitochondria were detected. Long-term dietary corn oil increased ACF in AOM-treated rats at 12 weeks and promoted colon cancer invasion at 48 weeks. Cancer invasion was not observed in the AOM-treated rats without dietary corn oil, although colon adenomas and cancers were detected. Apoptosis was decreased and cell proliferation was increased in the AOM-treated rats with dietary corn oil, compared with the AOM-treated rats with dietary basal diet. In these rats, mitochondrial wt p53 was significantly inhibited through decreased mitochondrial localization of wt p53 and increased cytosolic p53, resulting in the upregulation of Bcl-2 and Bcl-xL and the downregulation of Bak in the mitochondria. Results suggest that long-term dietary corn oil promotes AOM-induced colon cancer development partly by inhibiting the tumor suppressor gene p53-mediated mitochondria-dependent apoptosis.
Testaments for resilient structured overlay networks

The routing efficiency of structured overlay networks depends on the consistency of pointers between nodes. This consistency can, however, break temporarily when some overlay nodes fail, since it takes time to repair the broken pointers in a distributed manner. Conventional solutions utilize "backpointers" to quickly know the failure among the pointing nodes, which allows them to fix the pointers in a short time. Overlay nodes are, however, required to maintain backpointers for every pointing node which incurs significant consistency check and memory overheads. This paper proposes a novel light-weight protocol; an overlay node gives a "testament" containing its acquaintances (backpointers) only to its successor (i.e., clockwise closest node), and other nodes are freed from maintaining it. Our carefully-designed protocol guarantees that all acquaintances are registered with the testament even in the presence of churn, and the successor notifies the acquaintances for the deceased. Even if the successor passes away and the testament is lost, the successor of the successor can identify the acquaintances at a high success ratio. Simulations show that our protocol greatly reduces the mean time to repair (MTTR) and memory overheads while messaging cost increases.
Imaging performance of polycrystalline mercuric iodide films on CMOS readout arrays

Polycrystalline mercuric iodide (HgI2) films have great potential as direct-conversion x-ray detectors for digital x-ray imaging. The basic characteristics of HgI2, such as stopping power, mobility-lifetime product, and mean energy to create an electron-hole pair, are superior to or equivalent with those of other direct converters such as amorphous Se, PbI2, and CZT. Single-crystal HgI2 detectors have demonstrated excellent energy resolution and detection efficiency, and polycrystalline film performance has been approaching that of single crystals over the last few years. We have created high-resolution x-ray imaging devices using polycrystalline films grown directly onto CMOS readout chips using a thermal vapor transport process. The use of CMOS technology allows small pixels, fast readout speeds, and cost-effective devices due to well-developed fabrication processes.
AN ALGORITHM FOR A VALVED BRASS INSTRUMENT SYNTHESIS ENVIRONMENT USING FINITE-DIFFERENCE TIME-DOMAIN METHODS WITH PERFORMANCE OPTIMISATION

This paper presents a physical modelling sound synthesis environment for the production of valved brass instrument sounds. The governing equations of the system are solved using finite-difference time-domain (FDTD) methods and the environment is implemented in the C programming language. Users of the environment can create their own custom instruments and are able to control player parameters such as lip frequency, mouth pressure and valve openings through the use of instrument and score files. The algorithm for sound synthesis is presented in detail along with a discussion of optimisation methods used to reduce run time. Binaries for the environment are available for download online for multiple platforms.
Consensus Statement on the Use of Gonadotropin-Releasing Hormone Analogs in Children

OBJECTIVE. Gonadotropin-releasing hormone analogs revolutionized the treatment of central precocious puberty. However, questions remain regarding their optimal use in central precocious puberty and other conditions. The Lawson Wilkins Pediatric Endocrine Society and the European Society for Pediatric Endocrinology convened a consensus conference to review the clinical use of gonadotropin-releasing hormone analogs in children and adolescents. PARTICIPANTS. When selecting the 30 participants, consideration was given to equal representation from North America (United States and Canada) and Europe, an equal male/female ratio, and a balanced spectrum of professional seniority and expertise. EVIDENCE. Preference was given to articles written in English with long-term outcome data. The US Public Health grading system was used to grade evidence and rate the strength of conclusions. When evidence was insufficient, conclusions were based on expert opinion. CONSENSUS PROCESS. Participants were put into working groups with assigned topics and specific questions. Written materials were prepared and distributed before the conference, revised on the basis of input during the meeting, and presented to the full assembly for final review. If consensus could not be reached, conclusions were based on majority vote. All participants approved the final statement. CONCLUSIONS. The efficacy of gonadotropin-releasing hormone analogs in increasing adult height is undisputed only in early-onset (girls <6 years old) central precocious puberty. Other key areas, such as the psychosocial effects of central precocious puberty and their alteration by gonadotropin-releasing hormone analogs, need additional study. Few controlled prospective studies have been performed with gonadotropin-releasing hormone analogs in children, and many conclusions rely in part on collective expert opinion. The conference did not endorse commonly voiced concerns regarding the use of gonadotropin-releasing hormone analogs, such as promotion of weight gain or long-term diminution of bone mineral density. Use of gonadotropin-releasing hormone analogs for conditions other than central precocious puberty requires additional investigation and cannot be suggested routinely.
More on the Influence of End Constraints on Off-Axis Tensile Tests

An analytical investigation has been made of gripping effects on the off-axis tensile test results for flat specimens. It is an extension of the earlier work of Pagano and Halpin [1] and aims at establishing approxi mate bounds on the accuracy of the subject test. Considered are the cases of rigid clamping with and without end rotation for selected properties which are typical of glass, boron and graphite composites. Solutions of the corresponding mathematical models are effected numerically, utilizing a computerized finite-element approach. The results support the findings of [1] in demonstrating that length/width ratio and type of constraint can significantly modify the intended uniform stress/strain fields in the subject test. Despite this adverse effect, the analysis suggests that if strain measurements can be properly recorded, reasonably accurate test results should be obtain able for even small length/width specimens. Moreover, though the numerical results lack the generality of closed-form solutions, it would still appear that the trends estimated for the special glass, boron, and graphite systems are typical of other hard composite systems in these respective families.
Towards fog-based slice-defined WLAN infrastructures to cope with future 5G use cases

The advent of future 5th Generation (5G) use cases, such as ultra-dense networking and ultra-low latency propelled by Smart Cities and IoT projects will demand revolutionary network infrastructures. The need for low latency, high bandwidth, scalability, ubiquitous access and support for IoT resource-constrained devices are some of the prominent issues that networks have to face to support future 5G use cases, which arise since current wireless and mobile infrastructures are not able to fulfill. In particular, the pervasiveness and high-density of Wireless Local Area Networks (WLAN) at urban centers, together with their growing capacity and evolving standards, can be leveraged to support such demand. We argue that the integration of key 5G cornerstone technologies, such as Network Function Virtualization (NFV) and softwarization, fill some of the abovementioned gaps in regards to proper WLAN management and service orchestration. In this paper, we present a solution for slicing WLAN infrastructures, aiming to provide differentiated services on top of the same substrate through customized, isolated and independent digital building blocks. Through this proposal, we aim at efficiently handling ultra-dense networking 5G use cases to achieve benefits at unprecedented levels. Towards this goal, we present proof of concept realised over a real testbed and assess its feasibility.
Analysis of aryl hydrocarbon receptor ligands in kraft mill effluents by a combination of yeast bioassays and CG-MS chemical determinations

Aryl Hydrocarbon Receptor (AhR) ligands also known as dioxin-like compounds, constitute a substantial part of the total toxicity from many pollution sources, including pulp mill effluents. The aim of this article was to evaluate dioxin-like activity in different kraft mill effluents by a combination of yeast bioassays and gas chromatography-mass spectrometry (GC-MS) chemical analysis. The study includes kraft mill effluents from three sources of raw material: Pinus radiata, Eucalyptus globulus and a combination of both (50% each). The Recombinant Yeast Assay (RYA) showed an effective concentration of AhR ligands more than 30-fold higher in Eucalyptus globulus than in Pinus radiata effluents. Our results suggest that specific ligands, rather than the total amount of extractive material, determined the observed activity. Analysis of extract composition by GC-MS indicated that moderately hydrophobic aromatic compounds were likely responsible for the observed dioxin-like activity. In particular, benzaldehyde derivatives appeared as candidates for eliciting the observed dioxin-like activity in pulp mill effluents, giving their structural properties and their high concentration in AhR ligand-rich samples.
Associations between Reoperations and Psychological Factors after Contralateral Risk-Reducing Mastectomy: A Two-Year Follow-Up Study

Introduction. The aim of the study was to investigate associations between reoperations after contralateral risk-reducing mastectomies (CRRM) and emotional problems, body image, sexuality, and health related quality of life (HRQoL) in women with breast cancer and hereditary high risk. Patients and Methods. Patients scheduled for CRRM with breast reconstruction between 1998 and 2010 completed questionnaires, comprised of SF-36, the Hospital Anxiety and Depression Scale, the Body Image Scale, and the Sexual Activity Questionnaire, preoperatively and two years after CRRM. Data on reoperations was collected from medical charts. Results. A total of 80 women participated, with a response rate of 61 (76%) preoperatively and 57 (71%) at the two-year follow-up. At the two-year assessment, 44 (55%) patients had undergone ≥1 reoperation (reoperation group), whereas 36 (45%) had not (no reoperation group). No statistically significant differences between the groups were found for HRQoL, sexuality, anxiety, or depression. A higher proportion of patients in the “reoperation group” reported being dissatisfied with their bodies (81% versus 48%, p = 0.01). Conclusion. The results suggest associations between reoperation following CRRM with breast reconstruction and body image problems. Special attention should be paid to body image problems among women who are subject to reoperations after CRRM.
Reservation-based timing analysis - a practical engineering approach for distributed real-time systems

Proposes a timing analysis technique that gives practical support to the industrial systems engineering process for large-scale, distributed real-time systems. The technique, known as reservation-based timing analysis (RBA), gives support throughout the life-cycle of the system, from the early stages of system development through to implementation stages and later in-service upgrades. RBA allows the timing properties of the system to be validated incrementally throughout the system development and upgrades. This gives greater control over the costs associated with the development and upgrading of the real-time properties of the system.
Flow in Computer-Mediated Environments: Promises and Challenges

This paper provides a critical review to analyze the promises and important challenges of studying flow, a psychological state, in the computer-mediated environments (CME). Despite the strong interest in IS, HCI, Marketing, Education, and other research disciplines over more than a decade, adapting the phenomenon of flow to computer users shows high inconsistencies and discrepancies in the literature. In addition, few studies attempt to provide a coherent picture of the area. Based on a careful examination of the literature, we identify both conceptual and methodological challenges faced when studying flow in CME. Although not all challenges are resolved, we point out directions and possible solutions for some challenges and call for more studies in this promising area. The paper further discusses implications for research in human computing behavior in general and in flow in particular. It cautions researchers to examine hidden assumptions of theories in other disciplines before applying them to address IT related issues and concerns.
Algorithm for Automatic Forced Spirometry Quality Assessment: Technological Developments

We hypothesized that the implementation of automatic real-time assessment of quality of forced spirometry (FS) may significantly enhance the potential for extensive deployment of a FS program in the community. Recent studies have demonstrated that the application of quality criteria defined by the ATS/ERS (American Thoracic Society/European Respiratory Society) in commercially available equipment with automatic quality assessment can be markedly improved. To this end, an algorithm for assessing quality of FS automatically was reported. The current research describes the mathematical developments of the algorithm. An innovative analysis of the shape of the spirometric curve, adding 23 new metrics to the traditional 4 recommended by ATS/ERS, was done. The algorithm was created through a two-step iterative process including: (1) an initial version using the standard FS curves recommended by the ATS; and, (2) a refined version using curves from patients. In each of these steps the results were assessed against one expert's opinion. Finally, an independent set of FS curves from 291 patients was used for validation purposes. The novel mathematical approach to characterize the FS curves led to appropriate FS classification with high specificity (95%) and sensitivity (96%). The results constitute the basis for a successful transfer of FS testing to non-specialized professionals in the community.
Social attachments and traumatic stress

The extent to which we engage with our social world has been central to our survival as a species and, accordingly, is relevant to how we cope with trauma and adversity. This review summarises current knowledge about the importance of social connections from an evolutionary perspective, as well as integrating this with a discussion of prevailing attachment theories. Experimental research supporting the potential benefit of attachments for managing adversity are presented, along with a review of how these benefits are moderated by individual differences in attachment style. The potential impact of trauma on attachment systems, and the manner in which this can compound trauma stress is discussed. Finally, a broader overview of social network analysis is introduced and it is proposed that a more sociocentric framework of trauma response would promote a fuller understanding of how social processes moderate trauma response.
Cell Proliferation Ability of Mouse Fibroblast-Like Cells and Osteoblast-Like Cells on a Ti-6Al-4V Alloy Film Produced by Selective Laser Melting

Successful regeneration of tissues and organs relies on the application of suitable substrates or scaffolds in scaffold-based regenerative medicine. In this study, Ti-6Al-4V alloy films (Ti alloy film) were produced using a three-dimensional printing technique called Selective Laser Melting (SLM), which is one of the metal additive manufacturing techniques. The thickness of produced Ti alloy film was approximately 250 μm. The laser-irradiated surface of Ti alloy film had a relatively smooth yet porous surface. The non-irradiated surface was also porous but also retained a lot of partially melted Ti-6Al-4V powder. Cell proliferation ability of mouse fibroblast-like cells (L929 cells) and mouse osteoblast-like cells (MC3T3-E1 cells) on both the surfaces of Ti alloy film was examined using WST assay. Both L929 and MC3T3-E1 cells underwent cell proliferation during the culture period. These results indicate that selective laser melting is suitable for producing a cell-compatible Ti-6Al-4V alloy film for biomaterials applications.
P‐selectin and MAC‐1 mediate monocyte rolling and adhesion to ECM‐bound platelets under flow conditions

Accumulation of monocyte‐derived foam cells in focal areas of the atherosclerotic (A.S.‐) lesion is one of the key events in early atherogenesis. Using a flow model for the damaged vessel wall, we examined the ability of ECM‐bound platelets to induce monocyte tethering and adhesion. Whereas ECM‐proteins alone induced monocyte adhesion only at low shear stresses (<100 mPa), ECM‐bound platelets induced monocyte rolling and adhesion at shear stresses up to 240 mPa. Studies with specific antibodies showed that monocyte adhesion to platelets was mainly mediated by P‐selectin and monocyte PSGL‐1 (maximum inhibition 90%). β2‐Integrin blocking CD18 and CD11b antibodies partly inhibited the arrest of rolling cells. Antibodies against other adhesion molecules such as LFA‐1, PECAM‐1, and β1‐integrins had no effect. Even sparsely adhered platelets (~10% coverage of the surface) already strongly supported monocyte tethering. In conclusion, activated platelets present on ECM are a powerful adhesive substrate for monocyte recruitment under flow conditions. J. Leukoc. Biol. 64: 467–473; 1998.
Efficient mitochondrial biogenesis drives incomplete penetrance in Leber’s hereditary optic neuropathy

The mechanisms of incomplete penetrance in Leber’s hereditary optic neuropathy are elusive. Giordano et al. show that mitochondrial DNA content and mitochondrial mass are both increased in tissues and cells from unaffected mutation carriers relative to affected relatives and control individuals. Upregulation of mitochondrial biogenesis may represent a therapeutic target.
On Diversified Development of Scholarship in Local Colleges and Universities

In view of the problem of convergence of positioning and inaccuracy of social functioning for a large number of local colleges and universities in our country, this paper draws lessons from Ernest Boyer’s new paradigm of scholarship and its enlightenment on the diversified development of scholarship in America’s local colleges and universities, re-examines the mission of local colleges and universities for the local services in our country, and puts forward suggestions on diversified development of scholarship for local colleges and universities.
The Manual Work Instability Scale: development and validation.

BACKGROUND Increasing awareness of the burden of absenteeism and reduced performance at work highlights the importance of early identification of individuals experiencing work instability (WI), a mismatch between functional and cognitive abilities and job demands. AIMS To develop and validate a screening questionnaire to measure WI in manual workers. METHODS Questionnaire items were generated via qualitative interviews with manual workers and a draft survey instrument was completed by workers in a variety of fields. Rasch analysis was used interactively to assess the psychometric aspects of the emerging scale, including unidimensionality and absence of item bias (differential item functioning). RESULTS A total of 17 qualitative interviews generated 110 potential items for the questionnaire. The item set resolved to a 25-item scale, which satisfied model expectations (item residual mean = -0.13, SD = 1.04; person residual mean = -0.29, SD = 0.75), had good reliability (alpha = 0.86) and strict unidimensionality (t-test 7.5% confidence interval 3.8-11.2). CONCLUSIONS The Manual Work Instability Scale is a short psychometrically robust questionnaire based on the concept of WI, which incorporates both musculoskeletal symptoms and relevant psychosocial factors. It may prove effective in screening and identifying WI in workers in predominantly physical occupations.
Analysis and Improvement of Fitness Exploitation in XCS: Bounding Models, Tournament Selection, and Bilateral Accuracy

The evolutionary learning mechanism in XCS strongly depends on its accuracy-based fitness approach. The approach is meant to result in an evolutionary drive from classifiers of low accuracy to those of high accuracy. Since, given inaccuracy, lower specificity often corresponds to lower accuracy, fitness pressure most often also results in a pressure towards higher specificity. Moreover, fitness pressure should cause the evolutionary process to be innovative in that it combines low-order building blocks of lower accurate classifiers, to higher-order building blocks with higher accuracy. This paper investigates how, when, and where accuracy-based fitness results in successful rule evolution in XCS. Along the way, a weakness in the current proportionate selection method in XCS is identified. Several problem bounds are derived that need to be obeyed to enable proper evolutionary pressure. Moreover, a fitness dilemma is identified that causes accuracy-based fitness to be misleading. Improvements are introduced to XCS to make fitness pressure more robust and overcome the fitness dilemma. Specifically, (1) tournament selection results in a much better fitness-bias exploitation, and (2) bilateral accuracy prevents the fitness dilemma. While the improvements stand for themselves, we believe they also contribute to the ultimate goal of an evolutionary learning system that is able to solve decomposable machine-learning problems quickly, accurately, and reliably. The paper also contributes to the further understanding of XCS in general and the fitness approach in XCS in particular.