Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterization of a Eukaryotic-Like Tyrosine Protein Kinase Expressed by the Shiga Toxin-Encoding Bacteriophage 933W

ABSTRACT The Shiga toxin (Stx)-encoding bacteriophage 933W contains an open reading frame, stk, with amino acid sequence similarity to the catalytic domain of eukaryotic serine/threonine (Ser/Thr) protein kinases (PKs). Eukaryotic PKs are related by a common catalytic domain, consisting of invariant and nearly invariant residues necessary for ATP binding and phosphotransfer. We demonstrate that rather than a Ser/Thr kinase, stk encodes a eukaryotic-like tyrosine (Tyr) kinase. An affinity-purified recombinant Stk (rStk) autophosphorylates and catalyzes the phosphorylation of an artificial substrate on Tyr residues and not on Ser or Thr residues. A change of an invariant lysine within the putative catalytic domain abolishes this kinase activity, indicating that Stk uses a phosphotransfer mechanism similar to the mechanism used by eukaryotic PKs. We provide evidence suggesting that stk is cotranscribed with cI from the phage promoter responsible for maintaining CI expression during lysogeny. The stk gene was identified in prophages obtained from independently isolated Stx-producing Escherichia coli clinical isolates, suggesting that selective pressure has maintained the stk gene in these pathogenic bacteria.
Context-insensitive alias analysis reconsidered

Recent work on alias analysis in the presence of pointers has concentrated on context-sensitive interprocedural analyses, which treat multiple calls to a single procedure independently rather than constructing a single approximation to a procedure's effect on all of its callers. While context-sensitive modeling offers the potential for greater precision by considering only realizable call-return paths, its empirical benefits have yet to be measured. This paper compares the precision of a simple, efficient, context-insensitive points-to analysis for the C programming language with that of a maximally context-sensitive version of the same analysis. We demonstrate that, for a number of pointer-intensive benchmark programs, context-insensitivity exerts little to no precision penalty. We also describe techniques for using the output of context-insensitive analysis to improve the efficiency of context-sensitive analysis without affecting precision.
Feature selection for drug-drug interaction detection using machine-learning based approaches

This paper describes the systems developed for the DDI Extraction challenge. The systems use machine learning methods and are based on SVM by using LIBSVM and SVMPerf tools. Classical features and corpus-specific features are selected according to their F-score. The best system obtained an F-measure of 0.5965.
The ethical and relational implications of professional disclosure practices for certified rehabilitation counselors

THE ETHICAL AND RELATIONAL IMPLICATIONS OF PROFESSIONAL DISCLOSURE PRACTICES FOR CERTIFIED REHABILITATION COUNSELORS By Todd T. Lewicki The practice of professional disclosure involves the acknowledgement of the client’s right to autonomy and benefits client outcomes through fidelity, veracity, informed choice, the therapeutic relationship, and genuineness. Professional disclosure is hypothesized to strengthen establishment of an effective therapeutic relationship which leads to improved client outcomes. The Certified Rehabilitation Counselor (CRC) credential signifies that the CRC is well-prepared to practice in the field and operates consistently with the Commission on Rehabilitation Counselor Certification (CRCC) 2010 Code of Professional Ethics. Little is known about CRC therapeutic relationship outcomes relative to the use of professional disclosure practices, especially since the issuing of the 2010 CRCC Code of Professional Ethics for Rehabilitation Counselors. The purpose of this study was to review CRC use of the practice of professional disclosure, and its relationship to the therapeutic relationship with the client. The study utilized the results of an online survey of 249 CRCs responding to questions on the Real Relationship Inventory-Therapist (RRI-T) and the Professional Disclosure Survey-Modified (PDS-M) instruments. Simultaneous multiple regression analyses were performed between the demographic data and the two instruments. A simple linear regression was performed on the ability of the PDS-M to predict outcomes on the RRI-T. The simultaneous multiple regressions yielded relatively non-significant results, but the simple linear regression resulted in a significant effect (F(1,197)=23.4, p<. 001), indicating that professional disclosure practices of the CRC enhance the therapeutic relationship (genuineness) with the client. Implications for the field via education, training, supervision, and future research are discussed.
Evaluation of the What's Real: Myths & Facts about Marriage Curriculum: Differential Impacts of Gender*

ABSTRACT What’s Real is a high school marriage education curriculum designed to teach students how to develop healthy relationships and marriages. This study evaluated the effectiveness of this curriculum with 206 high school students who were in either the What’s Real group or a control group. Findings suggest that the curriculum increases knowledge of healthy relationship concepts, positively impacts attitudes related to students’ willingness to be involved in pre- and postmarital counseling, and increases students’ attitudes toward cohabitation avoidance. Implications for further development of the curriculum and other implications for practitioners and policymakers are discussed.
EFFECTS OF BALANCE TRAINING ON SELECTED SKILLS

The purpose of this study was to determine the effect of a 4-week balance training program on specified functional tasks. Thirty-six subjects (age = 22.7 ± 2.10 years; height = 168.30 ± 9.55 cm; weight = 71.15 ± 16.40 kg) were randomly placed into control (C; n = 19) and experimental groups (Tx; n = 17). The Tx group trained using a commercially available balance training device (BOSU). Postural limits (displacement and sway) and functional task (time on ball, shuttle run, and vertical jump) were assessed during a pretest (T1), a posttest (T2), and 2 weeks posttraining (T3). Multivariate repeated measures analysis (a = 0.05) revealed significant differences in time on ball, shuttle run, total sway, and fore/aft displacement after the exercise intervention (T2). T3 assessment revealed that total sway and time on ball remained controlled; however, no other measures were retained. Balance training improved performance of selected sport-related activities and postural control measures, although it is unclear whether the effect of training would transfer to general functional enhancement.
Age at Motherhood and Child Development: Evidence from the UK Millennium Cohort

Age at entry to motherhood is increasingly socially polarised in the UK. Early childbearing typically occurs among women from disadvantaged backgrounds relative to women with later first births. The Millennium Cohort finds differentials in their children's development, cognitive and behavioural, at age 5, by mother's age. These could be due to difficulties facing immature mothers, but much of it is attributable to young mothers’ social origins, or inequalities apparent at the age 0 survey, which may also have had earlier origins. The developmental penalty left to be attributed to the mother's age per se is, at most, modest.
Selective Retransmission of MPEG Video Streams over IP Networks

Internet multimedia streaming is becoming increasingly popular to access multimedia information. Two major issues arise in spite of its popularity. First, limited bandwidth restricts high bit rate video transmission. Second, wireless transmission by its nature may introduce higher rate of errors during transmission. The frequent errors should cause deterioration of the quality of multimedia streams. In this paper we present a selective retransmission algorithm for video streaming over IP networks where the video is streamed using DCCP transport protocol. The goal is to minimize the number of the corrupted bits, with acceptable transmission delay. The performance of the algorithm was confirmed by analytical examinations. The result shows that the quality of MPEG streams is increasing significantly compared with the currently used methods.
An Asset-Based Approach to Volunteering

Research demonstrates that volunteering provides many benefits for individuals and communities. However, research has not adequately addressed the potential significance of volunteering as a mechanism for low-income individuals to improve their own lives and support their communities. To account for the benefits volunteering could generate, research must shift from an emphasis on what low-income volunteers lack to an approach that uncovers the strengths and wealth present among low-income volunteers and their communities. The purpose of this article is to present a theoretically informed asset-based framework for analyzing volunteerism research. Through an examination of four nonfinancial assets—social capital, human capital, cultural capital, and political capital—we illustrate how an asset-based approach offers an opportunity to explore the ways low-income individuals could build and leverage assets through volunteering. Implications for future research that frames volunteering as an asset-building strategy are considered.
Crystallization of beta-estradiol in an acrylic transdermal drug delivery system.

Transdermal drug delivery systems are pharmaceutical products that can deliver controlled doses of drugs from polymeric patches applied on the human skin. The long-term stability of these patches is a critical issue relative to their performance in delivering drugs at a constant rate. Where a drug has been dissolved in the polymeric adhesive patch, crystallization has been reported in several systems. This study uses a variety of characterization tools to determine the physical and chemical nature of the precipitates formed in situ in estradiol patches. Optical microscopy revealed that crystals were formed in a single layer inside the adhesive matrix and that there were two distinctly different morphologies: needle-like crystals and aggregates around the needles. From IR measurements it was evident that estradiol probably was present in more than one crystal form in these patches. Raman microscopy showed that the needle-like crystals contain the adhesive component and the aggregates some modified crystal form of estradiol, indicating that in addition to the drug, the polymeric adhesive also crystallizes during storage.
Effects of Atmosphere Dominated Phase Fluctuation and Intensity Scintillation to DPSK System

Free-space-optical (FSO) coherent communication is a cost-effective, license-free, high-sensitivity and wide-bandwidth access technique for high date rates applications, whereas its performance strongly suffers from the turbulent atmosphere for the reason of both intensity scintillation and phase fluctuation. In this paper, the intensity scintillation is modeled as a multiplicative random process following the Gamma-Gamma distribution while the phase fluctuation is proved to satisfy Gaussian distribution. And the slow varying characteristic of the power spectrum destiny of the atmosphere is verified. In our research the Mach-Zehnder-interferometer (MZI) based coherent differential-phase-shift-keying (DPSK) transmission system is employed. And its bit-error-rate (BER) performance is studied with BER expression given by Meijer-G function substitution. Besides, a novel simulation model of the atmosphere channel is established based on which effects of the atmosphere to BER performance of the system are simulated. From the simulation, we know over FSO links, to guarantee the performance of the coherent system, measures should be taken to compensate the intensity of the signal when the Rytov variance is over 1.0, and the statistical standard deviation of the received signal frequency should be compensated to less than 100MHz when the transmission rate is 1Gbit/s. By comparing performances of MZI-DPSK and traditional PSK, the advantages of MZI-DPSK are presented.
Structured Floral Arrangement Program Developed for Cognitive Rehabilitation and Mental Health Care

structured floral arrangement (SFA) program was developed for cognitive rehabilitation and mental health care. This program required participants to create symmetrical floral arrangements as per predetermined procedures and with instructions given on the sequence of placing each natu- ral material. Attentional deficit, particularly unilateral spatial neglect, nearly disappeared after SFA intervention for a patient with traumatic brain damage. This positive effect was maintained for five months. In schizophrenic patients, visuospatial working memory was improved after SFA interven- tion. Motivational rehabilitation also increased through the SFA program. This program for mental health care was implemented for participants suffering traumatic stress from the Great East Japan Earthquake of 2011. The number of participants who showed mild physical symptoms (e.g., headache) decreased from seven to just one after SFA intervention. These findings suggest that the SFA pro- gram has the potential to improve brain function and/or mental health.
Learning and Visualizing Music Specifications Using Pattern Graphs

We describe a system to learn and visualize specifications from song(s) in symbolic and audio formats. The core of our approach is based on a software engineering procedure called specification mining. Our procedure extracts patterns from feature vectors and uses them to build pattern graphs. The feature vectors are created by segmenting song(s) and extracting time and and frequency domain features from them, such as chromagrams, chord degree and interval classification. The pattern graphs built on these feature vectors provide the likelihood of a pattern between nodes, as well as start and ending nodes. The pattern graphs learned from a song(s) describe formal specifications that can be used for human interpretable quantitatively and qualitatively song comparison or to perform supervisory control in machine improvisation. We offer results in song summarization, song and style validation and machine improvisation with formal specifications.
Urine œstrogen profiles OF Asian and North American women

Œstrone (El), œstradiol (E2) and œstriol (E3) were measured in the urine of Asian and North American women aged 15‐19, 20‐24 and 30‐39 years, during the follicular and luteal phases of the menstrual cycle. Each urine specimen was characterized by its œstriol proportion, E3/(E1+E2+E3). In each age group and cycle phase Asians had lower concentrations of œstrone and œstradiol and a higher oestriol proportion than North Americans. The differences were greatest in the youngest age group. Differences between the women from two North American cities or between women from three Asian areas were small. The data support the idea that the œstriol proportion, especially among young women, is a correlate of subsequent breast cancer risk.
2-Chloro-4-(2-iodobenzenesulfonamido)benzoic acid

In the title compound, C13H9ClINO4S, the dihedral angle between the aromatic rings is 81.04 (17)°. The disposition of the I and Cl atoms attached to the two rings is anti. In the crystal, molecules are connected via O—H⋯O and N—H⋯O hydrogen bonds.
Platelet Shape Changes and Adhesion Under High Shear Flow

Recent studies have revealed that the platelet adhesive process under flow is tightly regulated by multiple ligand-receptor interactions. However, platelet morphological changes during this process, particularly its physiological relevance, remain unknown under blood flow conditions. Using epifluorescence and scanning electron microscopy, we evaluated the real-time changes in platelet morphology during a platelet adhesive process on a von Willebrand factor-coated surface under physiological high shear flow in a perfusion chamber. Here, we show that dynamic platelet shape changes occurring during distinct phases of the adhesive process are precisely regulated by “inside-out” and “outside-in” integrin signals and are also a key regulatory element in successful platelet thrombogenesis opposing rapid blood flow in vivo.
Incidentally detected polycystic kidney and Caroli’s disease

Congenital cystic dilatation of the intrahepatic biliary ducts [Caroli’s disease (CD)] has been seldom seen in clinical practice. It is often associated with autosomal recessive polycystic kidney disease and congenital hepatic fibrosis. Here we report an image of a female asymptomatic patient with CD and polycystic kidney disease. A 51-year-old female patient with a one month history of pruritus visited our hospital for a routine health check up. She was undergoing treatment with her dermatologist for pruritus only with a prescription for local application. Her past medical history was unremarkable. Clinical examination was normal with only scratch marks. Laboratory investigations revealed normal hemogram, mildly elevated serum creatinine 1.3 (0.6-1.0) and normal electrolytes. Liver function test showed normal bilirubin with alanine aminotransferase 64 (5-30), AST 55 (5-30) and alkaline phosphatase 260 (30120) gamma-glutamyltransferase 314 (5-30) with normal albumin level. All viral serology was normal. MRI/MRCP showed enlarged kidneys with parenchymal replaced by cysts along with hepatic cyst communicating with biliary tree as shown in Fig. 1. Cystic lesions of the liver and kidney are increasingly being detected with the availability of newer imaging techniques [1]. Fibropolycystic disease can exist singly or in combination. They are usually inherited and consist of polycystic disease, congenital hepatic fibrosis, CD and choledochal cysts. CD is associated with renal involvement in up to 60%, and includes medullary sponge kidney disease or polycystic kidney disease [2]. CD can be asymptomatic or can present with cholangitis, intra hepatic stone formation or portal hypertension. CD is characterized by multifocal segmental dilatation of intrahepatic bile ducts affecting all or parts of the liver. Two forms of CD are described, the pure form and that associated with periportal fibrosis. The disease may diffusely affect the liver or be localized to one lobe or segment. Less than 20% of all reported cases of CD are monolobar type. Here we present an interesting image of CD localized mainly in the left lobe.
Energy Efficient Barring Factor Enabled Extended Access Barring for IoT Devices in LTE-Advanced

Synchronized Random Access Channel (RACH) attempts by Internet of Things (IoT) devices could result in Radio Access Network (RAN) overload in LTE-A. 3GPP adopted Barring Bitmap Enabled-Extended Access Barring (EAB-BB) mechanism that announces the EAB information (i.e., a list of barred Access Classes) through a barring bitmap as the baseline solution to mitigate the RAN overload. EAB-BB was analyzed for its optimal performance in a recent work. However, there has been no work that analyzes Barring Factor Enabled-Extended Access Barring (EAB-BF), an alternative mechanism that was considered during the standardization process. Due to the modeling complexity involved, not only has it been difficult to analyze EAB-BF, but also, a much more far-reaching issue, like the effect of these schemes on key network performance parameter, like eNodeB energy consumption, has been overlooked. In this regard, for the first time, we develop a novel analytical model for EAB-BF to obtain its performance metrics. Results obtained from our analysis and simulation are seen to match very well. Furthermore, we also build an eNodeB energy consumption model to serve the IoT RACH requests. We then show that our analytical and energy consumption models can be combined to obtain EAB-BF settings that can minimize eNodeB energy consumption, while simultaneously providing optimal Quality of Service (QoS) performance. Results obtained reveal that the optimal performance of EAB-BF is better than that of EAB-BB. Furthermore, we also show that not only all the three 3GPP-proposed EAB-BF settings considered during standardization provide sub-optimal QoS to devices, but also result in excessive eNodeB energy consumption, thereby acutely penalizing the network. Finally, we provide corrections to these 3GPP-settings that can lead to significant gains in EAB-BF performance.
Genes Associated with SLE Are Targets of Recent Positive Selection

The reasons for the ethnic disparities in the prevalence of systemic lupus erythematosus (SLE) and the relative high frequency of SLE risk alleles in the population are not fully understood. Population genetic factors such as natural selection alter allele frequencies over generations and may help explain the persistence of such common risk variants in the population and the differential risk of SLE. In order to better understand the genetic basis of SLE that might be due to natural selection, a total of 74 genomic regions with compelling evidence for association with SLE were tested for evidence of recent positive selection in the HapMap and HGDP populations, using population differentiation, allele frequency, and haplotype-based tests. Consistent signs of positive selection across different studies and statistical methods were observed at several SLE-associated loci, including PTPN22, TNFSF4, TET3-DGUOK, TNIP1, UHRF1BP1, BLK, and ITGAM genes. This study is the first to evaluate and report that several SLE-associated regions show signs of positive natural selection. These results provide corroborating evidence in support of recent positive selection as one mechanism underlying the elevated population frequency of SLE risk loci and supports future research that integrates signals of natural selection to help identify functional SLE risk alleles.
NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane

The positioning and the elongation of the mitotic spindle must be carefully regulated. In human cells, the evolutionary conserved proteins LGN/Gαi1‐3 anchor the coiled‐coil protein NuMA and dynein to the cell cortex during metaphase, thus ensuring proper spindle positioning. The mechanisms governing cortical localization of NuMA and dynein during anaphase remain more elusive. Here, we report that LGN/Gαi1‐3 are dispensable for NuMA‐dependent cortical dynein enrichment during anaphase. We further establish that NuMA is excluded from the equatorial region of the cell cortex in a manner that depends on the centralspindlin components CYK4 and MKLP1. Importantly, we reveal that NuMA can directly associate with PtdInsP (PIP) and PtdInsP2 (PIP2) phosphoinositides in vitro. Furthermore, chemical or enzymatic depletion of PIP/PIP2 prevents NuMA cortical localization during mitosis, and conversely, increasing PIP2 levels augments mitotic cortical NuMA. Overall, our study uncovers a novel function for plasma membrane phospholipids in governing cortical NuMA distribution and thus the proper execution of mitosis.
Helical-Ring Antenna for Hemispherical Radiation in Circular Polarization

A compact helical-ring antenna is proposed to realize a Huygens source in circular polarization. The radiation pattern of this antenna is mainly directed toward an half-space without the use of any reflector. The principle relies on the combination of two sets of collocated electric and magnetic short dipoles. The helical ring is excited by means of in-quadrature capacitive probes. Solutions are proposed to adjust the resonant frequency and balance the contributions of the magnetic and electric dipoles. The direction of the radiation pattern can be electrically switched frontward or backward by modifying the in-quadrature probes. Besides, the size of the antenna can be reduced by increasing the number of turns, therefore, without high-permittivity materials. The properties of this antenna are analyzed by means of simulations and confirmed via measurements on a prototype.