Miracle-dz/UniFAR-FTUs huggingface dataset:
Total nitric oxide production is low in patients with chronic renal disease.

BACKGROUND A deficiency of the endogenous vasodilator nitric oxide (NO) has been implicated as a potential cause of hypertension in chronic renal disease (CRD) patients. This study was conducted to determine whether 24-hour NOX (NO2 and NO3) excretion (a qualitative index of total NO production) is reduced in patients with CRD. METHODS Measurements were made in 13 CRD patients and 9 normotensive healthy controls after 48 hours on a controlled low-NOX diet. Urine was collected over the second 24-hour period for analysis of 24-hour NOX, and cGMP and blood drawn at the completion. Plasma levels of arginine (the substrate for endogenous renal NO synthesis), citrulline (substrate for renal arginine synthesis), and the endogenous NO synthesis inhibitor asymmetrical dimethylarginine (ADMA) and its inert isomer and symmetrical dimethylarginine (SDMA) were also determined. RESULTS Systolic blood pressure was higher in CRD patients (12 of whom were already on antihypertensive therapy) than in controls (P < 0.05). Twenty-four-hour urinary NOX excretion was low in CRD patients compared with controls despite similar dietary NO intake, suggesting that net endogenous NO production is decreased in renal disease. In contrast, the 24-hour urinary cGMP did not correlate with UNOXV. Plasma citrulline was increased in CRD patients, possibly reflecting reduced conversion of citrulline to arginine. Plasma arginine was not different, and plasma ADMA levels were elevated in CRD versus controls, changes that would tend to lower NO synthase. CONCLUSION These results suggest that NO production is low in CRD patients and may contribute to hypertension and disease progression in CRD.
Chinese stock bid-ask spread estimation and industry analysis

Bid-ask spread is an important indicator of market liquidity. In order to explore the characteristics of stock bid-ask spread in their industry and their changes over time mode. This paper uses Corwin(2010)'s new approach to estimate bid-ask spread, deal with the day's high and low price to calculate the spread, programmed and computed nearly 20 years and containing almost all of the stocks, importantly, categorized and analyzed the stock spread according to its industry property. Shanghai's spread was significantly lower than the Shenzhen's. And the spread show greater volatility when market ups or downs. However, the standard deviation of bid-ask spread in the whole time was gradually reduced. Different industries' bid-ask spread were highly relevant, but its variance were significant differences. By the impact of industrial policy, industries' bid-ask spread changed largely over the year.
Influence of prior active immunization on the presence of poliomyelitis virus in the pharynx and stools of family contacts of patients with paralytic poliomyelitis.

Isolations of poliovirus from 55 household contacts of 12 patients with paralytic poliomyelitis demonstrate that prior immunization does not prevent the acquisition of inapparent infection with poliovirus under conditions of household exposure. Although there was no apparent interference with enteric multiplication of poliovirus, an accurate estimate of the relative rates of acquisition of infection with poliovirus between immunized and unimmunized children of comparable ages was not possible. However, enteric infection with poliovirus appeared to be slightly less frequently encountered among the age group most frequently immunized. Poliovirus was present in the pharynges of previously immunized contacts of patients with paralytic poliomyelitis less frequently and in lower titer during the study period than in those without prior immunization. The apparent diminution in both presence and concentration of poliovirus in the pharynx in infections acquired after immunization may be important in the epidemiology of this infection in an immunized population where high standards of environmental sanitation are observed and good personal hygiene is practiced.
Sexual Motivation in Mateships and Sexual Conflict

The most frequent conflict within human mateships is the conflict between male sexual persistence and female sexual resistance. This conflict is nearly absent in the formation phase of a mateship and intensifies with time. It is rooted in sex-specific evolved programs encountering each other: a female program to secure male assistance and simultaneously remain open to new matings and a male program to guard paternity and to seek frequent copulation as a precaution against sperm competition. Mate value, the threat of infidelity, and attachment, moderate the conflict. Attachment motivation can be seen as a part of mating strategy or as a motivational system of its own, conflicting with demands of strategic flexibility. The theoretical framework of mating strategy accommodates many observations about sexual motivation within human mateships. However, sexual therapy has not yet taken much advantage of this body of knowledge. This might result from the different traditions of the respective scientific communities. It may also reflect a more substantial role of attachment than of mating strategy for the sexual life of a couple, since sexual therapy often focuses on issues of attachment,
Sound Field Reconstruction: An Improved Approach for Wave Field Synthesis

Wave field synthesis (WFS) is a prevalent approach to multiple-loudspeaker sound reproduction for an extended listening area. Although powerful as a theoretical concept, its deployment is hampered by practical limitations due to diffraction, aliasing, and the effects of the listening room. Reconstructing the desired sound field in the listening area, accounting for the medium propagation characteristic, is another approach termed as sound field reconstruction (SFR). It is based on the essential band-limitedness of the sound field, which enables a continuous matching of the reconstructed and the desired sound field by their matching on a discrete set of points spaced below the Nyquist distance. We compare the two approaches in a common single-source free-field setup, and show that SFR provides improved sound field reproduction compared to WFS in a wide listening area around a defined reference line.
Description of mandibular bone quality based on measurements of cortical thickness using Mental Index of male and female patients between 40-60 years old

Purpose The purpose of this study was to obtain the description of the mandibular bone quality of male and female patients between 40-60 years old and their differences based on mandibular cortical bone thickness measured using Mental Index (MI). Materials and Methods Forty digital panoramic radiographs, which consisted of twenty male and twenty female patients, 40-60 years old, were observed. Mandibular cortical bone thickness was measured using MI on both sides of the mandible. The average MI score of two groups were then assessed using t-sample independent test. Results There were significant differences of mandibular bone quality based on mandibular cortical bone thickness measurement using MI between male and female patients (p<0.05). Conclusion Mandibular bone quality based on cortical bone thickness measurement using MI of male and female patients indicated a significant difference.
Pharmaceutical Characterization of Tropomyosin Receptor Kinase B-agonistic Antibodies on Human Ips Cell-derived Neurons Running Title Page Running Title: Trkb-agonistic Antibodies on Human Ips Cell-derived Neurons Introduction

Brain-derived neurotrophic factor (BDNF) is a central modulator of neuronal development and synaptic plasticity in the central nervous system (CNS). This renders the BDNF-modulated tropomyosin receptor kinase B (TrkB) a promising drug target to treat synaptic dysfunctions. Using GRowth factor-driven expansion and INhibition of NotCH during maturation, the so-called GRINCH neurons were derived from human induced pluripotent stem (hiPS) cells. These GRINCH neurons were employed as model cells for pharmacological profiling of two TrkB-agonistic antibodies, hereafter referred to as AB2 and AB20. In next generation sequencing (NGS) studies, AB2 and AB20 stimulated transcriptional changes, which extensively overlapped with BDNF-driven transcriptional modulation. In regard to TrkB phosphorylation, both AB2 and AB20 were only about half as efficacious as BDNF. However, with respect to the TrkB downstream signaling, AB2 and AB20 displayed increased efficacy values, providing a stimulation at least comparable to BDNF in respect of VGF transcription as well as of AKT and CREB phosphorylation. In a complex structure of the TrkB-d5 domain with AB20, determined by x-ray crystallography, the AB20 binding site was found to be allosteric in regard to the BDNF binding site while AB2 was known to act orthosterically with BDNF. In agreement with this finding, AB2 and AB20 acted synergistically at higher concentrations to drive TrkB phosphorylation. Whilst TrkB downstream signaling declined faster after pulse stimulation with AB20 than with AB2, AB20 restimulated TrkB phosphorylation more efficiently than AB2. In conclusion, both antibodies displayed some limitations and some benefits in regard to future applications as therapeutic agents.
Måleegenskaper ved den norske versjonen av The Leyton Obsessional Inventory Child Version (LOI-CV)

Som alle artikler i PsykTestBarn, kan denne fagfellevurderte artikkelen lastes ned, skrives ut og distribueres fritt for alle slags formal pa folgende vilkar: korrekt referanse skal oppgis (se under), ingen kommersiell bruk, og ingen bearbeidelse av tekst eller innhold.
Pro-Anorexia and Pro-Recovery Photo Sharing: A Tale of Two Warring Tribes

Background There is widespread use of the Internet to promote anorexia as a lifestyle choice. Pro-anorexia content can be harmful for people affected or at risk of having anorexia. That movement is actively engaged in sharing photos on social networks such as Flickr. Objective To study the characteristics of the online communities engaged in disseminating content that encourages eating disorders (known as “pro-anorexia”) and to investigate if the posting of such content is discouraged by the posting of recovery-oriented content. Methods The extraction of pro-anorexia and pro-recovery photographs from the photo sharing site Flickr pertaining to 242,710 photos from 491 users and analyzing four separate social networks therein. Results Pro-anorexia and pro-recovery communities interact to a much higher degree among themselves than what is expected from the distribution of contacts (only 59-72% of contacts but 74-83% of comments are made to members inside the community). Pro-recovery users employ similar words to those used by pro-anorexia users to describe their photographs, possibly in order to ensure that their content appears when pro-anorexia users search for images. Pro-anorexia users who are exposed to comments from the opposite camp are less likely to cease posting pro-anorexia photographs than those who do not receive such comments (46% versus 61%), and if they cease, they do so approximately three months later. Our observations show two highly active communities, where most interaction is within each community. However, the pro-recovery community takes steps to ensure that their content is visible to the pro-anorexia community, both by using textual descriptions of their photographs that are similar to those used by the pro-anorexia group and by commenting to pro-anorexia content. The latter activity is, however, counterproductive, as it entrenches pro-anorexia users in their stance. Conclusions Our results highlight the nature of pro-anorexia and pro-recovery photo sharing and accentuate the need for clinicians to be aware of such content and its effect on their patients. Our findings suggest that some currently used interventions are not useful in helping pro-anorexia users recover. Thus, future work should focus on new intervention methods, possibly tailored to individual characteristics.
Final Discussion Better than All the Rest What's Supply Got to Do with It?

Lately, I’ve been watching television, and one of the people I see on it a lot is Tina Turner. Now Tina may seem to be an odd person to introduce into a central bank conference, but her songs have titles that fit pretty well with some of the issues raised by this Conference. First up, there is the line that she belts out on television in support of the local football code, while standing on what appears to be the Sydney Harbour Bridge: ‘better than all the rest’.
Understanding and Supporting Children with ADHD: Strategies for Teachers, Parents and Other Professionals

Introduction: Rationale and Overview UNDERSTANDING AD/HD Perspectives about AD/HD Experience of Living with AD/HD SUPPORTING CHILDREN WITH AD/HD Collaborative Working: For Teachers, Parents and Other Professionals Educational Interventions The Way Forward: Support In and Out of the Classroom CONCLUSIONS AND IMPLICATIONS
A new, simple method for quantifying gemcitabine triphosphate in cancer cells using isocratic high‐performance liquid chromatography

A deoxycytidine analog, gemcitabine (dFdC), is effective for treating solid tumors and hematological malignancies. After being transported into cancer cells, dFdC is phosphorylated to dFdC triphosphate (dFdCTP), which is subsequently incorporated into the DNA strand, thereby inhibiting DNA synthesis. Intracellular dFdCTP is the critical determinant for dFdC cytotoxicity, so therapeutic drug monitoring or in vitro testing of the capability of cancer cells to accumulate dFdCTP may be informative for optimizing dFdC administration. We have developed a new isocratic‐elution high‐performance liquid chromatography method for quantifying dFdCTP in cancer cells. Samples (500 µL) were eluted isocratically using 0.06 M Na2HPO4 (pH 6.9) containing 20% acetonitrile, at a constant flow rate of 0.7 mL/min and at ambient temperature. Separation was carried out using an anion‐exchange column (TSK gel DEAE‐2SW; 250 mm × 4.6 mm inside diameter, particle size 5 µL) and monitored at 254 nm. The standard curve was linear with low within‐day and interday variability. The lower detection limit (20 pmol) was as sensitive as that of the previous gradient‐elution method. dFdCTP was well separated from other nucleoside triphosphates. The method could measure dFdCTP in cultured or primary leukemic cells treated in vitro with dFdC. The method was also applicable to simultaneous determination of dFdCTP and cytarabine triphosphate, the results of which demonstrated ara‐CTP production augmented by dFdC pretreatment. Thus, our isocratic high‐performance liquid chromatography assay method will be of great use because of its sensitivity and simplicity as well as its applicability to biological materials. (Cancer Sci 2006; 97: 1274–1278)
An Adaptive Prefiltering Method to Improve the Speed/Accuracy Tradeoff of Voltage Sequence Detection Methods Under Adverse Grid Conditions

This paper deals with the improvement of the transient response and harmonic, subharmonic, and dc-offset voltage rejection capability of a grid voltage sequence detection scheme based on a second-order generalized integrator (SOGI). To perform that, the SOGI structure is first analyzed in deep, emphasizing both its tradeoff limits between settling time and harmonic attenuation and the sensitivity to grid subharmonics and dc-offset voltage. Then, a study of the effect of grid voltage harmonics and subharmonics in SOGI and in the SOGI-FLL and MSOGI-FLL structures is introduced. Hence, to overcome these problems, a new structure based on the use of the SOGI filter as prefilter for the previous structures is proposed to achieve a faster time response and higher harmonic rejection. This structure is used in a sequence detection scheme for the detection of the grid voltage components in the αβ-frame and it is applied in a three-phase PV system. Experimental and comparative results are shown to validate this proposal.
An Extended Semi-Supervised Regression Approach with Co-Training and Geographical Weighted Regression: A Case Study of Housing Prices in Beijing

This paper proposes an extended semi-supervised regression approach to enhance the prediction accuracy of housing prices within the geographical information science field. The method, referred to as co-training geographical weighted regression (COGWR), aims to fully utilize the positive aspects of both the geographical weighted regression (GWR) method and the semi-supervised learning paradigm. Housing prices in Beijing are assessed to validate the feasibility of the proposed model. The COGWR model demonstrated a better goodness-of-fit than the GWR when housing price data were limited because a COGWR is able to effectively absorb no-price data with explanatory variables into its learning by considering spatial variations and nonstationarity that may introduce significant biases into housing prices. This result demonstrates that a semisupervised geographic weighted regression may be effectively used to predict housing prices.
On the stability issues of linear Takagi-Sugeno fuzzy models

Stability issues of linear Takagi-Sugeno (TS) fuzzy models (1985, 1992) are investigated. We first propose a systematic way of searching for a common matrix, which, in turn, is related to stability for N subsystems that are under a pairwise commutative assumption. The robustness issue under uncertainty in each subsystem is then considered. We then show that the pairwise commutative assumption can, in fact, be relaxed by a similar approach as that for uncertainty. The result is applicable to a rather broad class of TS models, which are nonHurwitz and/or nonpairwise commutative.
Interleukin-4 Deficiency Does Not Exacerbate Disease in NOD Mice

To investigate the role of interleukin (IL)-4 in the regulation of autoimmune diabetes, we crossed the IL-4 knock-out mutation onto the NOD genetic background. This experiment was accelerated by typing for microsatellites linked to known diabetes susceptibility (Idd) loci, and included a control backcross of the wildtype 129/SvJ-derived IL-4 gene, the original target locus. We also crossed the mutation into the BDC2.5 transgenic line, a diabetes model that carries the rearranged T-cell receptor genes from a diabetogenic Tcell clone. The IL-4-null mutation did not accelerate or intensify insulitis in regular NOD mice or in the BDC2.5 transgenic model; it also had no effect on the timing or frequency of the transition to overt diabetes. These data indicate that IL-4 plays no required role in controlling the aggressiveness of murine diabetes.
The Quorum Programming Language (Abstract Only)

Quorum is a relatively new programming language that was originally designed for students with disabilities. In recent years, as its adoption has increased worldwide in K-12 (largely in middle/high school) and at universities, it has expanded to be a powerful, commercial-grade, programming language that includes support for 3D gaming, music, and other fun and creative activities. While new features are designed for all, they maintain compatibility for people with disabilities, including a novel way for individuals who are blind to create 3D games. Finally, Quorum is the first language to use human-factors evidence from both field data and randomized controlled trials in its design. This approach provides the broader research community an organized way to influence the design of the language over time according to evidence based practices. We call this approach evidence-oriented programming. A laptop would help participants follow along with the session and handouts will be provided. Quorum can be found at https://www.quorumlanguage. com/.
The Defect Detection Using Human Visual System and Wavelet Transform in TFT-LCD Image

The thin film transistor liquid crystal display (TFT- LCD) image has non-uniform brightness, which is the major difficulty in finding the defect region called Mura. To facilitate Mura segmentation, globally widely varying background signal has to be flattened and Mura signal must be enlarged. In this paper, Mura signal magnification and background signal flattening method is proposed using wavelet coefficients processing and the properties of human visual system (HVS). The wavelet approximation coefficients are used for background signal flattening while wavelet detail coefficients are employed to magnify Mura signal based on adapted contrast sensitivity function (ACSF). For the enhanced image, tri-modal thresholding segmentation technique is used for finding dark and white Mura at the same time. For final reliable defect confirmation, false region elimination algorithms based on Weber's law are also proposed. By the experimental results of TFT-LCD image, the proposed algorithms can have promising results and can be applied to the real automated TFT-LCD inspection system.
Transcriptional Analysis of Latent and Inducible Kaposi's Sarcoma-Associated Herpesvirus Transcripts in the K4 to K7 Region

ABSTRACT Kaposi's sarcoma-associated herpesvirus (KSHV) is a gamma-2 herpesvirus with a genome containing a long unique coding region (LUR) flanked by GC-rich terminal repeat sequences. The LUR encodes approximately 90 annotated open reading frames (ORFs) with complex patterns of gene expression during viral latency, reactivation, and de novo infection. To identify unannotated KSHV genes, we examined the region between 21,500 and 30,000 bp of the KSHV LUR, representing approximately 8.5 kb of sequence. This region encodes seven known single-exon ORFs (K4, K4.1, K4.2, K5, K6, K7, and PAN), but previous computer analyses have failed to identify additional likely genes in the remaining 5.2 kb. We identified four novel transcripts using Northern blotting, phage library screening, and 5′ rapid amplification of cDNA ends analysis in the region between ORFs K4.2 and K7. In vitro analysis of KSHV-infected primary effusion lymphoma cell lines in the presence of 12-O-tetradecanoylphorbol-13-acetate and phosphonoformic acid suggests that one latent transcript is coterminal with the previously annotated K3 gene encoding an ubiquitin-ligase known to downregulate major histocompatibility complex class I expression. This alternatively spliced transcript may contribute to KSHV adaptive immune evasion during latent infection. Other transcripts are inducible, including a 6.1-kb transcript that is the largest transcript found in the KSHV genome to date.
Selective Entrapment of Extrachromosomally Amplified DNA by Nuclear Budding and Micronucleation during S Phase

Acentric, autonomously replicating extrachromosomal structures called double-minute chromosomes (DMs) frequently mediate oncogene amplification in human tumors. We show that DMs can be removed from the nucleus by a novel micronucleation mechanism that is initiated by budding of the nuclear membrane during S phase. DMs containing c-myc oncogenes in a colon cancer cell line localized to and replicated at the nuclear periphery. Replication inhibitors increased micronucleation; cell synchronization and bromodeoxyuridine–pulse labeling demonstrated de novo formation of buds and micronuclei during S phase. The frequencies of S-phase nuclear budding and micronucleation were increased dramatically in normal human cells by inactivating p53, suggesting that an S-phase function of p53 minimizes the probability of producing the broken chromosome fragments that induce budding and micronucleation. These data have implications for understanding the behavior of acentric DNA in interphase nuclei and for developing chemotherapeutic strategies based on this new mechanism for DM elimination.