Miracle-dz/UniFAR-FTUs huggingface dataset:
Complement levels before and after dives with a high risk of DCS.

BACKGROUND Previously, complement activation has been associated with decompression sickness (DCS). However data, both in humans and in animals, are controversial. HYPOTHESIS Complement activation and depletion occurs after exposure to the hyperbaric environment and is associated with increasing risk of DCS. METHODS We obtained serological samples from 102 dives (120-300 feet of seawater) with a constant partial pressure of O2 set at 1.3 ATA in thirty-five U.S. Navy diver volunteers. Blood was obtained within one hour of diving and within one hour of surfacing. Plasma was extracted and analyzed for complement depletion. The risk of DCS was estimated using a validated model of DCS risk. RESULTS Pre-post dive concentrations of C3a were significantly related to estimated risk of DCS (Figure 1), but the variation in predicted DCS explained by C3a was small (correlation co-efficient (r2 = 0.19, p < 0.0001). CONCLUSIONS There was a reduction in total Ca3 levels in divers after exposure to dives with a high estimated risk of DCS. This decomplementation appeared to increase as the estimated risk of DCS increased.
Different moves, similar outcomes: a comparison of Chinese and Swedish preschool teacher education programmes and the revisions

A Chinese and a Swedish preschool teacher education programme were examined in search for commonalities and differences of the curriculum decision-making considerations involved in the respective programme revision process. Findings include: (1) the two programmes have shifted orientations and become similar, yet there was no fundamental paradigmatic shift after the revisions; (2) the Swedish programme has been heavily influenced by political agenda and national curriculum guidelines, while the Chinese one gives considerable attention to the opinions from the preschool circle; (3) the discussion of programme revision revolved around the diverse views of quality preschool education and teacher education; and (4) a strong relationship between the institutional/organisational features identified and the programme orientations was found. The empirical data suggested teacher educators’ professional views of quality preschool education and organisational/institutional characteristics are critical to the curriculum decision-making in the specific contexts.
An Automorphic Distance Metric and its Application to Node Embedding for Role Mining

Role is a fundamental concept in the analysis of the behavior and function of interacting entities in complex networks. Role discovery is the task of uncovering the hidden roles of nodes within a network. Node roles are commonly defined in terms of equivalence classes. Two nodes have the same role if they fall within the same equivalence class. Automorphic equivalence, where two nodes are equivalent when they can swap their labels to form an isomorphic graph, captures this notion of role. The binary concept of equivalence is too restrictive, and nodes in real-world networks rarely belong to the same equivalence class. Instead, a relaxed definition in terms of similarity or distance is commonly used to compute the degree to which two nodes are equivalent. In this paper, we propose a novel distance metric called automorphic distance, which measures how far two nodes are from being automorphically equivalent. We also study its application to node embedding, showing how our metric can be used to generate role-preserving vector representations of nodes. Our experiments confirm that the proposed automorphic distance metric outperforms a state-of-the-art automorphic equivalence-based metric and different state-of-the-art techniques for the generation of node embeddings in different role-related tasks.
Simple stochastic birth andz death models of genome evolution: was there enough time for us to evolve?

MOTIVATION The distributions of many genome-associated quantities, including the membership of paralogous gene families can be approximated with power laws. We are interested in developing mathematical models of genome evolution that adequately account for the shape of these distributions and describe the evolutionary dynamics of their formation. RESULTS We show that simple stochastic models of genome evolution lead to power-law asymptotics of protein domain family size distribution. These models, called Birth, Death and Innovation Models (BDIM), represent a special class of balanced birth-and-death processes, in which domain duplication and deletion rates are asymptotically equal up to the second order. The simplest, linear BDIM shows an excellent fit to the observed distributions of domain family size in diverse prokaryotic and eukaryotic genomes. However, the stochastic version of the linear BDIM explored here predicts that the actual size of large paralogous families is reached on an unrealistically long timescale. We show that introduction of non-linearity, which might be interpreted as interaction of a particular order between individual family members, allows the model to achieve genome evolution rates that are much better compatible with the current estimates of the rates of individual duplication/loss events.
Determiners and Clitic Pronouns in French-Speaking Children With SLI

This article presents the results of an investigation on elicited production and comprehension of determiners and clitic pronouns by 13 French-speaking children with specific language impairment (SLI) ages 5;7 to 13;0 years and a group of 20 normal children ages 5;6 to 5;11 years. Out findings show that the children with SLI studied here do not present a general impairment on functional categories or a general deficit in processing phonological weak elements. On the contrary, they all remain sensitive to the fundamental difference between determiners (Det and clitic pronouns. Their accuracy with respect to nominative and object clitic pronouns (reflexive and accusative) varies according to the categorial and syntactic properties of these elements. These findings confirm out linguistic analysis of Romance clitic pronouns that attributes a different status to Der and clitic pronouns and further views clitic pronouns as a nonhomogeneous class.
Situation Awareness and the Decision-Making Process in a Dynamic Situation: Avoiding Collisions at Sea

In this study, the authors aim to determine the impact of situation awareness (SA) in the decision-making process of “young” watch officers of a Merchant Marine training facility. The trainees were shown an ambiguous interaction situation in which they could choose among several actions. The results show that Level 1 SA (perception of the elements in the environment) tends to be of secondary importance in decision making. The major variables of the decision-making process are the interpretation of the rules and anticipation of the other vessel's intentions. Moreover, four different trainee “profiles” emerged. The main difference between them lies in the distance at which they decided to change course, the direction of this maneuver (port or starboard), the way in which they interpreted the other vessel's intentions (is it going to change course? ), and whether the trainees referred to the rules. Of the trainees, 55% performed a maneuver that was against regulations, and 34% did so in an unsafe manner. This result provides an incentive to rethink the training course to put more stress on recognizing prototypical situations and choosing which actions to take in situations such as the one presented here.
UK Defence Medical Services Guidance for the Use of Recombinant Factor VIIA (RFVIIA) in the Deployed Military Setting

Use of recombinant Factor VIIa (rFVIIa) for trauma is currently an ‘off label’ use. There are reports of rFVIIa contributing to the successful outcome of military trauma patients. This paper sets out the current position of the UK Defence Medical Services with regard to using rFVIIa in military trauma.
Societal, Environmental and Stakeholder Value Drivers

There is a shift in the role of business in society where societal, environmental and stakeholder value drivers could reshape the basis of economic competitive advantage. Investors are willing to pay a premium for well-governed companies because of positive perceptions of CSR. Organizations respond to the value drivers to endure and function effectively along the societal, environmental and stakeholder dimensions. In this article case analysis is performed for four international firms, chosen from USA/Europe and Asia, with distinguished records of sustainability. The case studies were based on the company sustainability reports and related material published in EthicalCorp, CSRWire and Covalence online publications. Assessments were performed using publicly available information. The non-parametric correlation analysis shows that firms with better commitment to CSR respond more to societal, environmental and stakeholder drivers through strategic initiatives. This improves their competitive advantage as assessed by economic value added.
Cancer risks in A-T heterozygotes.

It is well established that ataxia-telangiectasia (A-T) patients suffer a grossly elevated risk of cancer, particularly lymphoma and leukaemia, but the possibility of an excess cancer risk of cancer in heterozygotes carriers of A-T mutations is more controversial. A number of studies indicate that female relatives of A-T patients suffer excess risk of breast cancer; based on an overview of all currently available data the esti-mated relative risk of breast cancer to A-T heterozygotes is 3·9-fold (95%CI 2·1-7·2). There is some suggestion that relative risk declines with age. In contrast, there is no consistent evidence of a risk from any other cancer; the estimated risk from all studies is 1·9 (95%CI 1·5-2·5) but some studies show a larger effect whilst others show no excess risk. On the basis of these results and the likely frequency of the A-T gene, A-T heterozygotes would account for between 1 and 13% of breast cancer cases, with 3·8% being the best estimate. However, unless the breast cancer risk has been seriously underestimated, the A-T gene will make little contribution to familial breast cancer.
The Parent App

It’s the one loaded question that unites parents across the socioeconomic spectrum: ‘‘am I a ‘good enough’ parent? ’’ Lynn Schofield Clark’s The Parent App compellingly lays bare the inner workings of today’s family households as parents and youth wrestle with the challenges and opportunities that come with integrating digital and mobile media into their daily routines. In today’s technology inclusive economy, parents find themselves anxious to validate their child-rearing decisions, but those seeking advice are inundated with books, mobile apps, and Web sites promising to dish out what they want to hear, making it all the more difficult to understand what’s right and what’s not when it comes to parenting in the digital age. Parents might often wonder: ‘‘At what age should kids get cell phones? Is it OK to install monitoring software on the living room computer? What constitutes ‘normal’ media use behavior? ’’ In the preface of The Parent App, Clark makes one thing clear: the book is not intended to serve solely as an advice manual. Instead, Clark probes deeply into the realities of youths’ media use by considering ‘‘how families are experiencing and responding to the challenge, both new and old, of parenting young people through the late elementary, preteen and teen years’’ so that we can begin to understand the ‘‘meaning of the changes that we all experience’’ (p. x). Clark unravels this foundational question through a delicate balance of narratives and analysis. The core of the book is made up of qualitative research from Clark’s ten years spent exploring how families from diverse backgrounds experience and negotiate media use together and as individuals (chapter 1). Clark collected interviews from a total of 194 adolescents as well as 86 of their parents and 63 younger siblings
Illicit Wigmaking in Eighteenth-Century Paris

Guild statutes awarded master wigmakers in eighteenth-century France exclusive control over the hair industry. The wigmaker guild was uniquely organized on the basis of a royal charge that wigmakers purchased prior to becoming guild masters. Non-masters who ran independent wigmaking enterprises committed a crime against the social order that was taken seriously by the state. The essay describes the social network that spanned from the monarchy to the Parisian neighborhoods and that supported guild officers' routine confrontations of illicit wigmakers. Despite guild regulations to the contrary, illicit wigmakers, through their continuous presence, expanded their identities and, benefiting from bourgeois consumerism, contributed to historical changes in the hair industry. Confrontations with illicit wigmakers are examined as a form of conversation concerning the social organization of work. Conclusions are based on 635 confrontations with illicit wigmakers by guild officers in the presence of the Police du Châtelet between 1723 and 1764.
Fas ligand is up-regulated during the colorectal adenoma-carcinoma sequence.

AIMS Fas ligand (FasL) expression by cancer cells may mediate tumour immune privilege. The purpose of the present study was to investigate the timing and significance of FasL expression during the colorectal adenoma-carcinoma sequence. METHODS FasL expression was studied by immunohistochemistry in 170 formalin-fixed tissue sections representing the entire colorectal adenoma-carcinoma sequence. Reverse transcriptase polymerase chain reaction (RT-PCR) was used to search for FasL mRNA. Analysis of survival was performed in patients with carcinomas. RESULTS A significant positive linear correlation was found between FasL expression and tumour progression throughout the colorectal adenoma-carcinoma sequence (r(s)=0.677 P<0.001). A pattern of high FasL expression was detected in 19% of high grade adenomas, 40% of stage I-II, 67% of stage III and 70% of stage IV carcinomas. No significant differences were observed between FasL expression in the primary tumours and that in the corresponding liver metastases. The specificity of FasL expression was confirmed at RT-PCR. For stage I-II carcinomas, the 5 year survival was 90% in patients without, or with moderate, tumoural FasL expression compared with 60% in those with high tumoural FasL expression (P<0.05). CONCLUSIONS Our findings suggest that FasL expression may be involved in the development of colorectal cancer and its progression.
Tumor localization by tumor infiltrating lymphocytes labeled with indium-111 in patients with metastatic renal cell carcinoma, melanoma, and colorectal cancer.

BACKGROUND Adoptive immunotherapy with autologous tumor infiltrating lymphocytes (TIL) is a promising approach for cancer bio-therapy. One issue, however, is whether such cells actually migrate to sites of tumor after intravenous infusion. There have been several reports of tumor uptake of radiolabeled TIL in patients with metastatic melanoma, but efforts to visualize tumor with radiolabeled TIL in other tumor types reportedly have been unsuccessful. METHODS Eight patients with metastatic cancer (5 renal, 2 melanoma, 1 colon) received an intravenous infusion of 2 to 100 billion autologous TIL, including 50 million TIL which had been conjugated to 500 microCi Indium-111, co-administered with interleukin-2 (IL-2). One patient received 1 gm/m2 of cyclophosphamide one day prior to TIL; seven patients received interferon alpha 2b for 4 days prior to receiving TIL. Total body gamma camera imaging, including single photon emission computerized tomography (SPECT), was performed at 24 and 48 hours. RESULTS All eight patients had demonstrable uptake of 111-Indium-labeled TIL into one or more known sites of tumor. There were no known sites of tumor which were not imaged. Metastatic sites imaged included bone, brain, mediastinal and perihilar lymph nodes, lung and liver parenchyma, abdominal periaortic nodes, and a pelvic mass. One patient served as a negative control in that the TIL scan was negative at a time when she had no evident disease, but a few weeks later had a positive TIL scan which lead to a diagnosis of axillary recurrence. CONCLUSION Uptake of radiolabeled TIL, whether CD8+ or CD4+, by metastatic renal cell carcinoma and other carcinomas was similar to that previously reported in melanoma. Pretreatment with cyclophosphamide was not a prerequisite for imaging, and TIL uptake did not predict tumor response.
Detection and Location of Generation Trips in Large Transmission Grids

The consumption behavior provokes frequency deviations that are controlled by power plants contributions to ancillary services. The trip of an important power generator obliges the transmission grid operator to buy energy through the balancing mechanism. Having real-time information about generation unit trips is also interesting for power producers. This kind of hints allows them to quantify the origins of major frequency deviations and to identify which power system produced such a deviation. Dynamic frequency deviation analysis allow several conclusions concerning serious faults detection and location. Present paper details generator trips detection method based on power oscillations and frequency monitoring. In addition, some numerical simulation results obtained on the UCTE (Union for the Coordination of Transmission of Electricity) grid are presented.
Regulation of phosphatidate phosphatase activity by inositol in Saccharomyces cerevisiae

Regulation of phosphatidate phosphatase (EC 3.1.34) activity was examined in Saccharomyces cerevisiae cells supplemented with phospholipid precursors. Addition of inositol to the growth medium of wild-type cells resulted in a twofold increase in phosphatidate phosphatase activity. The increase in phosphatidate phosphatase activity was not due to soluble effector molecules, and inositol did not have a direct effect on enzyme activity. The phosphatidate phosphatase activity associated with the mitochondrial, microsomal, and cytosolic fractions of the cell was regulated by inositol in the same manner. Cells supplemented with inositol had elevated phospholipid levels and reduced triacylglycerol levels compared with unsupplemented cells. Serine, ethanolamine, and choline did not significantly affect the phosphatidate phosphatase activity of cells grown in the absence or presence of inositol. Enzyme activity was not regulated in inositol biosynthesis regulatory mutants, suggesting that regulation by inositol is coupled to regulation of inositol biosynthesis. Phosphatidate phosphatase activity was pleiotropically expressed in structural gene mutants defective in phospholipid biosynthesis. These results suggested that phosphatidate phosphatase was regulated by inositol at a genetic level.
Jaagsiekte Sheep Retrovirus Biology and Oncogenesis

Jaagsiekte sheep retrovirus (JSRV) is the causative agent of a lung cancer in sheep known as ovine pulmonary adenocarcinoma (OPA). The disease has been identified around the world in several breeds of sheep and goats, and JSRV infection typically has a serious impact on affected flocks. In addition, studies on OPA are an excellent model for human lung carcinogenesis. A unique feature of JSRV is that its envelope (Env) protein functions as an oncogene. The JSRV Env-induced transformation or oncogenesis has been studied in a variety of cell systems and in animal models. Moreover, JSRV studies have provided insights into retroviral genomic RNA export/expression mechanisms. JSRV encodes a trans-acting factor (Rej) within the env gene necessary for the synthesis of Gag protein from unspliced viral RNA. This review summarizes research pertaining to JSRV-induced pathogenesis, Env transformation, and other aspects of JSRV biology.
Parents' Lack of Understanding of Their Children's Bilingual Education Program

Abstract This study provides information about 19 families that have children enrolled in a bilingual kindergarten class in the Spring Branch Independent School District in Houston, Texas. This paper concerns the parents' understanding of the bilingual program their children attend. The study revealed that a miniscule number of parents are familiar with the practices and policies in place at their children's school and that their expectations for English-language instruction vary widely from what is actually happening in the classroom.
The anatomy and physiology of primate neurons that control rapid eye movements.

Primates are frontal eyed animals possessing a sophisticated retina endowed with a highly differentiated foveal region with which the visual scene can be examined in detail. Vision is very important to these animals and is probably the predominant sensory modality with which they orient themselves and interact with the world. The relationship between the visual system and the motor system that moves the eyes (oculomotor) is intimate. Motion of the visual scene across the retina, particularly the fovea, can degrade visual acuity. Hence there is a necessity for accurate oculomotor control. Not surprisingly, a considerable portion of the brain� including the superior colliculus (sq, the frontal eye field (FEF), the thalamus, and the cerebellum as well as several brainstem nuclei, is entrusted with the control of eye movements (Hepp et al 1989). The most ubiquitous movements of the eyes are the rapid ones (also called saccadic) that reorient the eyes quickly toward interesting features of the surrounding world. During a saccade, two or more of six extraocular muscles
Events-coverage based spatio-temporal association rules mining method

Spatio-temporal association rules mining is a key technology and a hot issue in the field of spatio-temporal data mining. The classical Apriori algorithm is usually utilized to detect the spatio-temporal association rules from the spa- tio-temporal transaction table, which is derived from the original spatio-temporal data. In most existing approaches to generate the spatio-temporal transaction table, many defects, such as data redundancy, further affects the efficiency of spatio-temporal association rules mining. This paper proposes an events-coverage based spatio-temporal association rules mining (ECSTAR for short) to overcome these limitations. ECSTAR employs the event's coverage to divide the researching spatio-temporal domain into some cells to generate a spatio-temporal transaction. Among each cell, spatio-temporal relationship predications are utilized to present the spatio-temporal relationship between the events and spatio-temporal objects. Thus, the spatio-temporal transaction table is built and spatio-temporal association rules are mined by the Apriori algorithm. Moreover, many concepts about ECSTAR are expounded and its algorithm is narrated in detail. Finally, a practical experiment demonstrates the feasibility and validity of the ECSTAR.
A cavity-backed angled-dipole antenna array for low millimeter-wave bands

A cavity-backed angled-dipole antenna is proposed for low millimeter-wave band wireless applications. A cavity-backed reflector was utilized to improve the radiation characteristics of the angled dipole, such as gain, back-radiation, and 3-dB beamwidths in the E- and H-planes. The design, with a cavity aperture of 0.5λ28-ghz × 0.5 λ28-ghz, resulted in a |S11| <; -10 dB bandwidth of 26.7-30.6 GHz, a gain of 7.5 dBi and 3-dB beamwidths of approximately 70° for both the E- and H-planes at 28-GHz. Using tapered excitation, 0° and 40° fixed-scan angle eight-element arrays were implemented with the proposed antenna to achieve a high-gain and low side-lobe levels.