Miracle-dz/UniFAR-FTUs huggingface dataset:
Increased frequency of genetic thrombophilia in women with complications of pregnancy.

BACKGROUND Obstetrical complications such as severe preeclampsia, abruptio placentae, fetal growth retardation, and stillbirth are associated with intervillous or spiral-artery thrombosis and inadequate placental perfusion. Whether these complications are associated with an increased frequency of thrombophilic mutations is not known. METHODS We studied 110 women who had one of the above-mentioned obstetrical complications and 110 women who had one or more normal pregnancies. The women were tested several days after delivery for the mutation of guanine to adenine at nucleotide 1691 [corrected] in the factor V gene (factor V Leiden), the mutation of cytosine to thymine at nucleotide 677 in the gene encoding methylenetetrahydrofolate reductase, and the mutation of guanine to adenine at nucleotide 20210 in the prothrombin gene. Two to three months after delivery the women were tested for deficiency of protein C, protein S, or antithrombin III and for the presence of anticardiolipin antibodies. RESULTS The mutation at nucleotide 1691 [corrected] in the factor V gene was detected in 22 of the women with obstetrical complications and in 7 of the women with normal pregnancies (20 percent and 6 percent, respectively; P=0.003). Twenty-four women with complications, as compared with nine women without complications, were homozygous for the C677T mutation in the gene encoding methylenetetrahydrofolate reductase (22 percent and 8 percent, respectively; P=0.005). The G20210A mutation in the prothrombin gene was found in 11 women with complications as compared with 3 women without complications (10 percent and 3 percent, respectively; P=0.03). Overall, 57 women with obstetrical complications had a thrombophilic mutation, as compared with 19 women with normal pregnancies (52 percent and 17 percent, respectively; P<0.001). Deficiency of protein S, protein C, or antithrombin III or anticardiolipin antibodies were detected in an additional 14 women with complications, as compared with 1 woman with a normal pregnancy (13 percent and 1 percent, respectively; P<0.001). CONCLUSIONS Women with serious obstetrical complications have an increased incidence of mutations predisposing them to thrombosis and other inherited and acquired forms of thrombophilia.
Three-month outcome of patients with suspected acute coronary syndrome using point-of-care cardiac troponin-T testing compared with laboratory-based cardiac troponin-T testing: a randomised trial

Objective The aim of this randomised trial was to determine clinical outcomes in patients suspected of an acute coronary syndrome (ACS) who had cardiac troponin-T measured by point-of-care (POC) compared with laboratory-based cardiac troponin-T testing. A secondary aim was to describe the correlation between the two troponin assays. Methods Adults suspected of ACS were allocated to have troponin processed by POC or laboratory analyser. The primary outcome was a composite of acute myocardial infarction, coronary revascularisation, cardiac arrest and mortality at 3 months. Paired troponins taken on participants allocated to POC were used to determine correlation between troponin values obtained from laboratory and POC analysers. Results There were 452 participants. 30 (13.1%) of 229 participants allocated to POC had at least one primary outcome event compared with 29 (13.0%) of 223 allocated to laboratory testing, a difference of 0.1% (95% CI −6.2% to 6.4%, p=0.98). Of 215 available paired troponins results, both analysers gave congruent results in 196 (91%) cases. The POC troponin was negative when the laboratory sample was positive in 16 (7%) cases. The POC troponin was positive when the laboratory sample was negative in 3 (1%) samples. Passing–Bablok regression analysis demonstrated both a constant and proportional difference between the two analytic methods. Conclusions Among patients suspected of an ACS, we found no evidence for a difference in adverse outcome when POC troponin was used in comparison with laboratory troponin. Due to the small sample size, an absolute difference of up to 6% in adverse outcome is possible. Trial registration number ANZCTR#12612000319875.
Perkembangan Bank Syariah PAsca UU 21 Tahun 2008

Islamic banking system still grows continuously over time in various countries, including Indonesia. Although it was a bit late, if it was compared to another, Islamic banking system began to develop in Indonesia in the early 1990’s. At that time, Islamic banking, however, was still running with its all characteristics based on the rule without adequate law. Islamic banking began to be recognized legally as the legalization of UU Perbankan 1992, and it was followed by its deregulation in 1998, and Islamic banking in Indonesia finally got its full legality after legalization of UU Perbankan Syariah in 2008. UU Perbankan Syariah as a new law certainly has significance for the development of Islamic banking in Indonesia. Based on the BI statistics, Islamic banks, especially Bank Umum Syariah after legalization of UU Perbankan Syariah, has been growing significantly, among in the number of banks, total assets, and total financing. Unfortunately, the growth of PLS (profit and loss sharing) doesn’t occupy a significant position in total financing of Islamic banks, whereas PLS is core system in Islamic banking.
An adaptive TV model for image denoising

By analyzing three important denoising models: the harmonical model, the TV (total variation) model and the generalized TV model, we have proposed an adaptive one which is named `adaptive TV image denoising model'. On the basis of SNR of noisy images, this model can pretreat them with Gaussian filter, so as to overcome the staircase effect in the TV model. Then by utilizing the gradient information of every pixel point of the image, we can adaptively select the most appropriate denoising scheme. The results of numerical experiments show that this method can preserve significant image details while removing the noise. Compared with other variational denoising methods, especially at high noise levels, the method achieves at least about 1.0dB gain for Peak Signal to the Noise Ratio (as PSNR for short) measurement.
[The relationship between the sympathetic nerves and immunocytes in the spleen].

Ever since Galen, the ancient Greek physician, said "Melancholic women develop disease more than sanguine women," it has been said that the mental condition affects the physical condition. However, there is hardly any scientific verification. About half a century ago, Selye (1936) proposed a relationship between stress and immune function, and it is becoming increasingly clear that the nervous system and immune system interact with each other. Also researchers have strongly hoped to demonstrate the existence of specific pathways by which immunocytes can be directly regulated by the nervous elements instead of by the humoral influence of immunomodulators. In this study, the author showed by electron microscopic observation how the immunocytes in the guinea pig spleen are directly innervated. The sustentacular supporting element of the guinea pig spleen is the connective tissue system which includes the capsulo-trabecular, peri-vascular and reticular systems. The latter system is composed of the outer sheath of the reticular cell or its cellular processes which have abundant microfilaments and the inner minute connective tissue space in which lamina densa-like material, collagenous fibrils, elastic fibers and nervous elements are present. The sympathetic adrenergic nerves for the spleen enter the organ, and scatter around the arterial walls. All components of the connective tissue system are continuous with each other, and the nervous elements appearing in the reticular system are the elongated ones from other connective tissue systems, especially peri-vascular connective tissue. Thus, the adrenergic nerves are more abundant in the white pulp, into which the central artery penetrates, than in the red pulp which arterioles or capillaries pass through. The minute connective tissue space of the reticular system may be called the noradrenalin (NA) canal because catecholamine released from the naked adrenergic nerve terminals in this tissue diffuses and is stored in this enclosed space. The reticular system in the spleen divides the parenchyma into small non-endothelial vascular spaces owing to its meshwork, and free mobile immunocytes, such as T-cells, B-cells and macrophages, stagnate in these spaces. This stagnation of the mobile immunocytes and the presence of the adrenergic nerves in the NA canals provide the chance for the immunocytes and nerves to meet each other in the following fashion; the reticular cell sheaths show the exposed phenomena owing to the contraction of the microfilament-rich reticular cell processes, caused by noradrenalin in the NA canal, and the nervous elements in the NA canals can face the nonendothelial vascular spaces where mobile immunocytes pass freely. (ABSTRACT TRUNCATED AT 400 WORDS)
Fast Hierarchical Multimodal Structuring of Time Slots

TV stream structuring consists primarily in breaking down the stream into advertisings, telecasts and time slots. These time slots and telecasts need then to be structured. This paper focuses on the structuring of one of the dayparts: the morning drive. The challenge resides in these morning drives' components heterogeneity under a same theme and branding: music, weather, news, sets, advertisings and reports are mixed. Classical structuring methods concern videos with homogeneous components, like sport games, and need few features. We propose here a solution to time slots structuring by modeling morning drives' structure in order to decrease the number of needed detections and to decrease the number of false alarms. Good results are obtained since 97% of the segments are correctly retrieved and since the accuracy of the retrieved structure is approximately 5 seconds.
Histologic Classification of Penile Carcinoma and Its Relation to Outcome in 61 Patients with Primary Resection

A retrospective review of the clinical and pathologic features of 61 cases of penile squamous cell carcinoma (SCC), all treated by primary surgical resection at the Memorial Sloan Kettering Cancer Center during the period 1949-1992, was undertaken. Inguinal lymph node dissection material was evaluated in 40 cases. All carcinomas were of squamous cell type and were classified as follows: usual type, 36 cases (59%); papillary, not otherwise specified (NOS), 9 cases (15%), basaloid, 6 cases (10%); warty (condylomatous), 6 cases (10%); verrucous, 2 cases (3%), and sarcomatoid, 2 cases (3%). A high rate of nodal metastasis and poor survival were found for the basaloid and sarcomatoid neoplasms (5 of 7 patients with metastasis, 71%, and 5 of 8 dead of disease, 63%). Only 1 patient with a verruciform tumor (defined as a tumor of nonspecific papillary, warty, or verrucous type) had inguinal node metastasis and none died from penile cancer. An intermediate rate of metastasis and mortality (14 of 26, 54%, and 13 of 36, 36%, respectively) was found for typical SCC. Penile carcinomas are morphologically heterogeneous, and there is a correlation of histologic type and biologic behavior. This mandates accurate histologic subtyping by the pathologist.
Effect of divalproex-lamotrigine combination therapy in frontal lobe seizures.

CONTEXT Patients with intractable frontal lobe seizures represent a difficult subclass of patients with epilepsy. When medications fail, surgical outcomes typically have not been as successful as medial temporal lobe resections. The combination therapy of valproic acid (divalproex sodium) and lamotrigine has shown promising results in patients with uncontrolled seizures. OBJECTIVE To determine outcome in patients with intractable frontal lobe seizures who were treated with the combination of divalproex and lamotrigine. DESIGN A nonrandomized, open-label, add-on trial. SETTING Outpatients evaluated and treated at a tertiary care referral facility. PATIENTS Twenty-one patients between 16 and 65 years old were studied. Patients were required to have failed at least 3 prior trials with antiepilepsy drugs. Criteria for frontal lobe onset included 1 or more of the following: frontal lesion on scan, positive ictal single-photon emission computed tomographic scan, symptoms consistent with frontal lobe onset, or an electroencephalogram (surface or invasive) consistent with frontal lobe onset. INTERVENTION Patients were treated with divalproex-lamotrigine combination therapy for 1 year. MAIN OUTCOME MEASURES The main outcome measured was seizure reduction. Safety and tolerability were also evaluated. RESULTS Four patients discontinued therapy. Ten of the remaining 17 became completely free of seizures. Two rashes occurred, but did not lead to discontinuation of therapy. The most common adverse events were tremor and weight gain. CONCLUSION Divalproex-lamotrigine combination therapy is a reasonable alternative in intractable frontal lobe epilepsy.
Biomimetic fabrication of a three-level hierarchical calcium phosphate/collagen/hydroxyapatite scaffold for bone tissue engineering

A three-level hierarchical calcium phosphate/collagen/hydroxyapatite (CaP/Col/HAp) scaffold for bone tissue engineering was developed using biomimetic synthesis. Porous CaP ceramics were first prepared as substrate materials to mimic the porous bone structure. A second-level Col network was then composited into porous CaP ceramics by vacuum infusion. Finally, a third-level HAp layer was achieved by biomimetic mineralization. The three-level hierarchical biomimetic scaffold was characterized using scanning electron microscopy, energy-dispersive x-ray spectra, x-ray diffraction and Fourier transform infrared spectroscopy, and the mechanical properties of the scaffold were evaluated using dynamic mechanical analysis. The results show that this scaffold exhibits a similar structure and composition to natural bone tissues. Furthermore, this three-level hierarchical biomimetic scaffold showed enhanced mechanical strength compared with pure porous CaP scaffolds. The biocompatibility and osteoinductivity of the biomimetic scaffolds were evaluated using in vitro and in vivo tests. Cell culture results indicated the good biocompatibility of this biomimetic scaffold. Faster and increased bone formation was observed in these scaffolds following a six-month implantation in the dorsal muscles of rabbits, indicating that this biomimetic scaffold exhibits better osteoinductivity than common CaP scaffolds.
Cutting Edge: Functional Interactions Between Toll-Like Receptor (TLR) 2 and TLR1 or TLR6 in Response to Phenol-Soluble Modulin1

Toll-like receptor (TLR) 2 and TLR4 play important roles in the early, innate immune response to microbial challenge. TLR2 is preferentially involved in the inflammatory response to lipoteichoic acid, lipopeptides, and glycans from a variety of microbes, whereas TLR4 is essential for a complete response to LPSs. We report here that TLR2 transduces the response to phenol-soluble modulin, a factor secreted by Staphylococcus epidermidis. The TLR2-mediated response to this modulin was enhanced by TLR6 but inhibited by TLR1, indicating a functional interaction between these receptors. We also demonstrate that a response to phenol-soluble modulin mediated by TLR2 and TLR6 was more refractory to inhibition by TLR1 than one mediated by TLR2 alone.
Cytosine deaminase expressing human mesenchymal stem cells mediated tumour regression in melanoma bearing mice

Previously, we validated capability of human adipose tissue‐derived mesenchymal stem cells (AT‐MSC) to serve as cellular vehicles for gene‐directed enzyme prodrug molecular chemotherapy. Yeast fusion cytosine deaminase : uracil phosphoribosyltransferase expressing AT‐MSC (CDy‐AT‐MSC) combined with systemic 5‐fluorocytosine (5FC) significantly inhibited growth of human colon cancer xenografts. We aimed to determine the cytotoxic efficiency to other tumour cells both in vitro and in vivo.
Explanation about the Causes of Ecological Degradation in the "Sanjiangyuan"District Under the Perspectives of New Institutional Economics

"Sanjiangyuan" district,the poorest and Tibetan-congregated part which is located in the hinterland of Tibeto-Qinghai Plateau,is the headstream of Yangtze River,Yellow River and Lantsang River.At present,this district is confronted by ecological degradation.The paper holds the main causes lay both in the drought of the climate and in the aggravation of human activity,but it is worth to mention that institutional factors are the ultimate cause.The paper gives a new explanation about the ecological degradation of "Sanjiangyuan" from the angles of the deficiency of property rights of grassland,law flaws of natural resources and environment and cultural transfer from animal husbandry to agriculture by use of the ideas and methods of the new institutional economics.
Topology, Modeling, and Design of Switched-Capacitor-Based Cell Balancing Systems and Their Balancing Exploration

A series of switched-capacitor (SC) cell balancing circuits is proposed for rechargeable energy storage devices like battery and supercapacitor strings in this paper. Taking a basic SC-based cell balancing unit as an equivalent resistor, the behavioral models of the proposed cell balancing circuits are developed to evaluate their balancing performance. Comparing with existing SC-based cell balancing circuits, the main advantage of the proposed circuits is that their balancing speed is independent of both of the number of battery cells and initial mismatch distribution of cell voltages. In order to improve the operation performance of SC-based cell balancing circuits in the respect of minimizing the equivalent resistance, optimizing methodologies of circuit parameters are introduced by referring the concepts of slow switching limit and fast switching limit as well as inductive switching limit of SC power converters. Simulation and experimental results are provided to verify the feasibility of the proposed cell balancing circuits.
Effects of temperature on calcium current of bullfrog sympathetic neurons.

1. The temperature dependence of whole‐cell calcium current was studied in bullfrog sympathetic neurons. 2. The factor by which the peak calcium current increased upon a 10 degrees C increase in temperature (Q10) was 1.6 +/‐ 0.1 (mean +/‐ S.E.M., n = 9), for a change from 20 to 30 degrees C. 3. Activation and deactivation were more rapid at a higher temperature. The Q10 was approximately 7 in the middle of the voltage range (near ‐10 mV), where the kinetics were slowest. Time constants were less temperature dependent at more positive or negative voltages (Q10 approximately 2 at ‐70 mV). 4. Near ‐10 mV, activation and deactivation were associated with a large enthalpy and a large positive entropy change. Deactivation at ‐70 mV reflected a smaller enthalpy change, and almost no change in entropy. 5. Activation is only slightly more temperature dependent than deactivation, when both are measured at the same voltage. 6. The peak current shifts slightly (approximately 5 mV) to more negative voltages upon a change from 20 to 30 degrees C. 7. Inactivation has a Q10 of approximately 2 at ‐10 mV. 8. Changes in the kinetics of activation or inactivation could be observed during recording at a constant temperature. These changes were generally small, especially for activation kinetics, and could be distinguished from temperature‐dependent changes. 9. The changes in entropy and Q10 with voltage suggest that the rate‐limiting steps for activation and deactivation are different at extreme voltages vs. the middle of the voltage range.
The Nuclear RhoA Exchange Factor Net1 Interacts with Proteins of the Dlg Family, Affects Their Localization, and Influences Their Tumor Suppressor Activity

ABSTRACT Net1 is a RhoA-specific guanine nucleotide exchange factor which localizes to the nucleus at steady state. A deletion in its N terminus redistributes the protein to the cytosol, where it activates RhoA and can promote transformation. Net1 contains a PDZ-binding motif at the C terminus which is essential for its transformation properties. Here, we found that Net1 interacts through its PDZ-binding motif with tumor suppressor proteins of the Dlg family, including Dlg1/SAP97, SAP102, and PSD95. The interaction between Net1 and its PDZ partners promotes the translocation of the PDZ proteins to nuclear subdomains associated with PML bodies. Interestingly, the oncogenic mutant of Net1 is unable to shuttle the PDZ proteins to the nucleus, although these proteins still associate as clusters in the cytosol. Our results suggest that the ability of oncogenic Net1 to transform cells may be in part related to its ability to sequester tumor suppressor proteins like Dlg1 in the cytosol, thereby interfering with their normal cellular function. In agreement with this, the transformation potential of oncogenic Net1 is reduced when it is coexpressed with Dlg1 or SAP102. Together, our results suggest that the interaction between Net1 and Dlg1 may contribute to the mechanism of Net1-mediated transformation.
Nonlinear identification of alstom gasifier based on wiener model

In this work a nonlinear identification approach has been developed and implemented on Alstom gasifier with Wiener model. The linear element of the Wiener model is identified by a combined subspace state space method, which integrates MOESP (Multivariable Output-Error State Space) and N4SID (Numerical algorithms for subspace state space system identification) method in the estimation of system matrices. A single layer neural network is chosen as the nonlinearity of the model. The quadruple system matrices are identified firstly according to the given input-output sample data. Then an initial approximation of the static nonlinear part is determined with the output sequence of linear part. At last, all parameters of the wiener model are optimized by Levenberg-Marquardt algorithm, using the model parameters obtained formerly as the initial estimates. A nonlinear model of the plant at 0% load is adopted as a base model for estimation because it is the most difficult case to control among three operating conditions. The proposed model identification method was used to model Alstom gasifier with strong nonlinearity and multivariable couples, compared to a combined linear subspace identification method. The results demonstrate that the nonlinear identification proposed, which may be applied to nonlinear predictive control, behave better approximation than the linear method.