Miracle-dz/UniFAR-FTUs huggingface dataset:
Spatial covariability of the climatic parameters in the Greek area

In this work, 12 monthly climatic parameters of 49 Meteorological stations in Greece are classified according to their spatial covariability, in order to define groups of climatic elements having the same, characteristic, spatial distribution. The grouping of the parameters is achieved objectively by using the method of factor analysis. The analysis is applied to the winter months of January and February and to the summer months of July and August. In winter, the parameters are classified into four groups as follows: (i) maximum, mean and minimum temperature and, negatively, pressure and number of frost days; (ii) wind and, negatively, diurnal temperature range; (iii) precipitation; and (iv) cloudiness and relative humidity. In summer, the parameters are classified into three groups, namely: (i) precipitation, cloudiness and, negatively, minimum temperature; (ii) maximum and mean temperature, relative humidity; and (iii) wind. From the above groups the most interesting is group (i) of summer, as its parameters belong to different groups in winter. Finally, the study of the spatial distribution of the above groups showed that some depend on latitude, others on the continentality and others on the leeward or windward character of the various areas. Copyright © 1999 Royal Meteorological Society
Efficient integration of electrocoagulation treatment with the spray‐pyrolyzed activated carbon coating on stainless steel electrodes for textile effluent‐bath reuse with ease

In this study, the electrocoagulation (EC) treatment was used to minimize and separate pollutants from textile industrial wastewater (TIWW), including high color, chemical oxygen demand (COD), total organic carbon (TOC), and total dissolved solids (TDS). To enhance the EC treatment efficiency, a novel strategy has been followed in the study that involves thin‐film coating on 316 stainless steel (SS) electrodes with banana peel‐derived activated carbon (BPAC) by dip coating, spin coating, or spray coating. Among the different types of coating, thickness and contact angle measurements have elucidated that the spray coating of BPAC on SS electrode is the best tool with minimum thickness and contact angle. In this study, a bare SS electrode was used as the anode and a thin‐film spray‐coated BPAC on the SS electrode was used as the cathode. Moreover, optimization plays a key role in EC treatment process, where operating conditions such as a current density of 10 mA/cm2, contact time of 15 min, and a pH of 7 were fixed. As a result, the findings indicate comparatively high color removal of 98%, COD removal of 91%, TOC removal of 89.6%, and TDS removal of 68% are achieved with ease. Accordingly, in comparison with plain SS electrodes or dip‐ or spin‐coated BPAC on SS electrodes, spray‐coated BPAC on SS electrodes in EC treatment outperforms in removing high color, TOC, COD, and TDS. Overall, the study highlights the potential of EC treatment integrated with adsorption procedures for TIWW treatment. Particularly, the use of thin‐film spray‐coated BPAC on SS electrodes in the EC treatment process led to an effective and sustainable tool for treating and reuse of TIWW. It is due to its low operation and maintenance cost and studied in a short interval of time. Finally, the ultimate goal was firmly achieved in pilot‐scale studies by the safe discharge into the environment or reuse of treated textile wastewater. Thus, it is a promising alternative with an environmentally friendly footprint that could be easily implemented in any textile industry premises.
A Mixed-Methods Feasibility Study of a Gamified Therapy Prescription App for Children with Neurodisability.

AIM Determine the feasibility of a gamified therapy (occupational therapy, physiotherapy, speech pathology) prescription app developed for children with neurodisability for delivering school and home therapy programs (the Zingo app). METHOD A mixed-methods feasibility study was conducted with children (and their parents, therapists, and teachers) with neurodisability (n = 8, female= 5) who were prescribed a 4-week individualized therapy program by their usual treating therapist using Zingo. Primary outcome measures were program adherence, engagement, app quality, and user experience, collected with quantitative and qualitative methods. RESULTS Mean adherence to the program was 58.0% (SD 27.2). Our combined Engagement Index (EI) score was 74.4% (SD 11.7). App quality measured using Mobile Application Rating Scale- User version was 4.6/5 (SD 0.7, n = 6) for parents, 4.6/5 (SD 0.5, n = 5) for teachers, and 4.4/5 (SD 0.6, n = 6) for therapists. Thematic analysis of semi-structured interviews yielded a primary theme of "app as motivator" for therapy. CONCLUSIONS Adherence findings were affected by COVID-19 outbreak however remain comparable with other studies in this cohort. EI findings compared favorably with other studies. The findings are supportive of the feasibility of Zingo for delivering home and school therapy programs for children with neurodisability and was found to motivate therapy program completion.
Antibiotics do not induce expression of acrAB directly but via a RamA-dependent pathway

ABSTRACT The aim of this study was to determine if acrAB induction in Salmonella Typhimurium relies solely on RamA or if other transcriptional activator pathways are also involved, and to better understand the kinetics of induction of both acrAB and ramA. We evaluated the expression of acrAB in S. Typhimurium in response to a variety of compounds that are known to induce the expression of one or more of the transcriptional activators, MarA, SoxS, RamA, and Rob. We utilized green fluorescent protein (GFP) transcriptional reporter fusions to investigate the changes in the expression of acrAB, ramA, marA, and soxS following exposure to sub-inhibitory concentrations of antimicrobial compounds. Of the compounds tested, 13 induce acrAB expression in S. Typhimurium via RamA, MarA, SoxS, and Rob-dependent pathways. None of the tested antibiotics induced acrAB expression, and compounds that induced acrAB expression also induced a general stress response. The results from this study show that the majority of compounds tested induced acrAB via the RamA-dependent pathway. However, none of the antibiotic substrates of the AcrB efflux pump directly increased the expression of AcrAB either directly or indirectly via the induction of one of the transcriptional activators. Using a dual GFP/RFP reporter, we investigated the kinetics of the induction of ramA and acrAB simultaneously and found that acrAB gene expression was transient compared to ramA gene expression. ramA gene expression increased with time and would remain high or decrease slowly over the course of the experiment indicating that RamA exerts a wider global effect and is not limited to efflux regulation alone.
Feed forward Artificial Neural Network model to predict the average summer-monsoon rainfall in India

In the present research, possibility of predicting average summer-monsoon rainfall over India has been analyzed through Artificial Neural Network model. In formulating the ANN — based predictive model, three-layer network has been constructed with sigmoid non-linearity. The monthly summer monsoon rainfall totals, tropical rainfall indices and sea surface temperature anomalies have been considered as predictors while generating the input matrix for the ANN. The data pertaining to the years 1950–1995 have been explored to develop the predictive model. Finally, the prediction performance of neural net has been compared with persistence forecast and Multiple Linear Regression forecast and the supremacy of the ANN has been established over the other processes.
Measuring and Comparing Clinical Productivity of Individual Anesthesiologists

Measuring and comparing clinical productivity of individual anesthesiologists is confounded by anesthesiologist-independent factors, including facility-specific factors (case duration, anesthetizing site utilization, type of surgical procedure, and non–operating room locations), staffing ratio, number of calls, and percentage of clinical time providing anesthesia. Further, because anesthesia care is billed with different units than relative value units, comparing work with other types of clinical care is difficult. Finally, anesthesia staffing needs are not based on productivity measurements but primarily the number and hours of operation of anesthetizing sites. The intent of this review is to help anesthesiologists, anesthesiology leaders, and facility leaders understand the limitations of anesthesia unit productivity as a comparative metric of work, how this metric often devalues actual work, and the impact of organizational differences, staffing models and coverage requirements, and effectiveness of surgical case load management on both individual and group productivity. Because of anesthesiologist-independent factors, measuring clinical productivity of individual anesthesiologists cannot be done simply by using units billed per anesthesiologist and requires in-depth understanding of how these multiple factors impact measurements and anesthesiologists’ productivity.
On the parameters influencing air‐water gas exchange

Detailed gas exchange measurements from two circular and one linear wind/wave tunnels are presented. Heat, He, CH4, CO2, Kr, and Xe have been used as tracers. The experiments show the central importance of waves for the water-side transfer process. With the onset of waves the Schmidt number dependence of the transfer velocity k changes from k ∝ Sc−⅔ to k ∝ Sc−½indicating a change in the boundary conditions at the surface. Moreover, energy put into the wave field by wind is transferred to near-surface turbulence enhancing gas transfer. The data show that the mean square slope of the waves is the best parameter to characterize the free wavy surface with respect to water-side transfer processes.
Observations of stress-dependent microstructural changes in cement-stabilized soil

Pore parameters of cement-stabilized soil samples were obtained by a mercury intrusion test to allow evaluation of the influence of microstructural characteristics on the macromechanical properties. Samples were subjected to a range of unconfined stresses (fractions of their unconfined compressive strength). Five characteristic pore size classes were determined (larger than 40 μm, 40–2.5 μm, 2.5–0.4 μm, 0.4–0.04 μm and less than 0.04 μm) and changes in the relative proportions of these classes were used to evaluate structural changes and the development of progressive failure of the cement-stabilized soils. The results show that in this cement-stabilized soil changes in applied stress have a significant effect on variations in micropore content. No obvious changes were observed in the proportions of larger pores during the initial loading stage. However, these proportions changed significantly as failure approached. The porosity of the samples showed a tendency to increase (dilatancy) after an initial decline.
A Suture-specific Photo Score for Metopic Synostosis

Head shape assessments in children with metopic synostosis are a relevant outcome measure in addition to functional measures, such as neurocognitive outcomes, behavioral outcomes, and visual functioning outcomes. However, consensus on head shape assessments in children with metopic synostosis is lacking. The aim of this study is to develop a reproducible and reliable suture-specific photo score that can be used for cross-center comparison of phenotypical severity of metopic synostosis and evaluation of esthetic outcome of treatment later in childhood. We conducted a retrospective study among nonsyndromic metopic synostosis patients aged <18 years. Preoperative and postoperative photosets of patients with metopic synostosis from 6 expert centers were included. The photo score was discussed in the group of expert craniofacial plastic surgeons and pediatric neurosurgeons. Interrater reliability was determined with modified weighted Fleiss’ kappa and intraclass correlation coefficients. Correlation between individual photo score items with overall phenotype was assessed using Spearman correlation analyses. The metopic synostosis photo score contained the following items: “wedging of the forehead”, “hypotelorism”, “temporal hollowing”, “biparietal widening,”and an assessment of “overall phenotype”. Items were scored on a 4-point ordinal scale ranging from normal to severe. We found moderate interrater reliability for all items, but substantial agreement for the summed scores. Correlation with overall phenotype was lowest for biparietal widening. To conclude, although agreement on individual photo score items was suboptimal, the agreement on the summed score was substantial, which indicates there is consensus on the overall severity of the metopic synostosis phenotype.
Feasibility of Using the Privacy-preserving Large Language Model Vicuna for Labeling Radiology Reports.

Background Large language models (LLMs) such as ChatGPT, though proficient in many text-based tasks, are not suitable for use with radiology reports due to patient privacy constraints. Purpose To test the feasibility of using an alternative LLM (Vicuna-13B) that can be run locally for labeling radiography reports. Materials and Methods Chest radiography reports from the MIMIC-CXR and National Institutes of Health (NIH) data sets were included in this retrospective study. Reports were examined for 13 findings. Outputs reporting the presence or absence of the 13 findings were generated by Vicuna by using a single-step or multistep prompting strategy (prompts 1 and 2, respectively). Agreements between Vicuna outputs and CheXpert and CheXbert labelers were assessed using Fleiss κ. Agreement between Vicuna outputs from three runs under a hyperparameter setting that introduced some randomness (temperature, 0.7) was also assessed. The performance of Vicuna and the labelers was assessed in a subset of 100 NIH reports annotated by a radiologist with use of area under the receiver operating characteristic curve (AUC). Results A total of 3269 reports from the MIMIC-CXR data set (median patient age, 68 years [IQR, 59-79 years]; 161 male patients) and 25 596 reports from the NIH data set (median patient age, 47 years [IQR, 32-58 years]; 1557 male patients) were included. Vicuna outputs with prompt 2 showed, on average, moderate to substantial agreement with the labelers on the MIMIC-CXR (κ median, 0.57 [IQR, 0.45-0.66] with CheXpert and 0.64 [IQR, 0.45-0.68] with CheXbert) and NIH (κ median, 0.52 [IQR, 0.41-0.65] with CheXpert and 0.55 [IQR, 0.41-0.74] with CheXbert) data sets, respectively. Vicuna with prompt 2 performed at par (median AUC, 0.84 [IQR, 0.74-0.93]) with both labelers on nine of 11 findings. Conclusion In this proof-of-concept study, outputs of the LLM Vicuna reporting the presence or absence of 13 findings on chest radiography reports showed moderate to substantial agreement with existing labelers. © RSNA, 2023 Supplemental material is available for this article. See also the editorial by Cai in this issue.
A sub-10-nm, folic acid-conjugated gold nanoparticle as self-therapeutic treatment of tubulointerstitial fibrosis

Significance Chronic kidney disease (CKD) affects ~10% of adults worldwide. Prolonged renal fibrosis leads to CKD and ultimately kidney failure that requires dialysis or transplantation. Current drugs can retard disease progression, but there are no specific treatments for tubulointerstitial fibrosis, a common manifestation of end-stage CKD. Nanomedicines hold immense potential for treating CKD, but their delivery to renal tubules is challenging, and many past examples were preventive. Leveraging the overexpression of folate receptors on selected tubule cells in the fibrotic kidney, this sub-10-nm folic acid–conjugated gold nanoparticle can selectively accumulate in the fibrotic kidney, enter tubules, inhibit CKD-related kinases, and treat tubulointerstitial fibrosis after disease establishment. Consideration of pathophysiology and adoption of self-therapeutic nanoparticles will jointly inspire effective treatments.
Diagnostic study of climate feedback processes in atmospheric general circulation models

A method is proposed to diagnose climate feedbacks of water vapor, temperature lapse-rate, and cloud variations in atmospheric general circulation models. It is then applied to study differences in sensitivity of the National Center for Atmospheric Research community climate model (CCM2) and two hybrid versions of CCM2 with different cumulus-convection schemes. Water vapor feedback and temperature lapse-rate feedback differ among the models due to different efficiencies of heat and moisture transport by cumulus convections. A large compensation occurs between water vapor feedback and temperature lapse-rate feedback. This leads to similar clear-sky sensitivities in the models. Cloud-radiative feedback is negative in CCM2 with a ΔSST climate change due to the vigorous cumulus-convective scheme. Stronger convection warms the upper troposphere and reduces its cloudiness more, resulting in negative longwave cloud-radiative feedback. In models where a moist-adiabatic-adjustment scheme and then a decoupling of the atmospheric boundary layer are subsequently used, intensity of cumulus convection is successively reduced and cloud-radiative feedback changes to either neutral or positive.
Effects of

To compare the effects of short-term (i.e., 7 week) plyometric training applied before (PJT-B) or after (PJT-A) soccer practice on components of physical fitness in young soccer players, a single-blind randomized controlled trial was conducted. Post-pubertal boys aged 17.0±0.5 years were allocated to three groups: PJT-B (n=12), PJT-A (n=14), and control (CON; n=12). The outcome measures included tests to evaluate 20-m speed, standing long jump [SLJ], squat jump [SJ], countermovement jump [CMJ], and drop jump [DJ], 20-m multistage shuttle running speed [MSSRT], and Illinois change of direction speed [ICODT]. While the CON performed soccer-specific training, the PJT-A and PJT-B groups conducted the same soccer-specific sessions but replaced ~11% of their time with plyometric training. The PJT-B group performed plyometric exercises after a warm-up program, and the PJT-A group conducted plyometric exercises ~10 minutes after the completion of soccer training. Analyses of variance (ANOVAs) were used to detect differences between groups in all variables for pre-and post-training tests. Main effects of time (all p<.01; d=0.19-0.79) and group x time interactions (all p<.05; d=0.17-0.76) were observed for all examined variables. Post hoc analyses revealed significant increases in the PJT-B group (SLJ: 9.4%, d=1.7; CMJ: 11.2%, d=0.75; 20-m MSSRT: 9.0%, d=0.77) and the PJT-A group (SLJ: 3.1%, d=0.7; CMJ: 4.9%, d=0.27; 20-m MSSRT: 9.0%, d=0.76). Post hoc analyses also revealed significant increases in the PJT-B group (20-m speed: -7.4%, d=0.75; 20-cm DJ reactive strength index: 19.1%, d=1.4; SJ: 6.3%, d=0.44; ICODT results: -4.2%, d=1.1). In general, our study revealed that plyometric training is effective in improving measures of physical fitness in young male soccer players when combined with regular soccer training. More specifically, larger training induced effects on physical fitness were registered if plyometric training was conducted prior to soccer specific training.
Availability of comparative real-world evidence research in Medicare patients: implications for Centers for Medicare and Medicaid Services drug price negotiations

Aim: To evaluate the availability of published comparative real-world evidence (RWE) studies in Medicare patients for the ten drugs set to undergo Centers for Medicare and Medicaid Services (CMS) price negotiations in 2026. Materials & methods: A scoping review was completed in MEDLINE/PubMed to evaluate the availability of comparative RWE investigations conducted among Medicare-eligible patient populations in the US for the following drugs: apixaban, rivaroxaban, sitagliptin, ibrutinib, empagliflozin, etanercept, dapagliflozin, sacubitril/valsartan, ustekinumab and insulin aspart. Results: Of the 170 real-world comparative studies identified, 55 (32.4%) used Medicare real-world data (RWD) while 34 (20.0%) used commercial claims data in conjunction with either Medicare Advantage or Medicare Supplementary databases. The number of studies varied considerably by drug with apixaban and rivaroxaban studies accounting for the majority (i.e., 67.1%) of comparative RWE studies. Approximately a third or less of the comparative RWE studies were conducted in CMS RWD per drug. Conclusion: Our results demonstrate there is a considerable amount of comparative RWE for apixaban, rivaroxaban, and etanercept but limited comparative RWE for the other drugs set to undergo CMS price negotiations in 2026; additionally, our findings set up a number of next steps (e.g., risk of bias assessments) for further exploration of the available evidence base. Overall, CMS and manufacturers should consider proactively generating high-quality comparative RWE studies in the Medicare population to ensure that future price negotiations are based on robust evidence.
Chimeric antigen receptor T cell and regulatory T cell therapy in non-oncology diseases: A narrative review of studies from 2017 to 2023

ABSTRACT Recently, the remarkable success of chimeric antigen receptor T cell (CAR-T) therapy in treating certain tumors has led to numerous studies exploring its potential application to treat non-oncology diseases. This review discusses the progress and evolution of CAR-T cell therapies for treating non-oncology diseases over the past 5 years. Additionally, we summarize the advantages and disadvantages of CAR-T cell therapy in treating non-oncological diseases and identify any difficulties that should be overcome. After conducting an in-depth analysis of the most recent studies on CAR-T technology, we discuss the key elements of CAR-T therapy, such as developing an effective CAR design for non-oncological diseases, controlling the rate and duration of response, and implementing safety measures to reduce toxicity. These studies provide new insights into different delivery strategies, the discovery of new target molecules, and improvements in the safety of CAR-T therapy for non-oncological diseases.
Breakdown of the growth–mortality trade-off along a soil phosphorus gradient in a diverse tropical forest

An ecological paradigm predicts that plant species adapted to low resource availability grow slower and live longer than those adapted to high resource availability when growing together. We tested this by using hierarchical Bayesian analysis to quantify variations in growth and mortality of ca 40 000 individual trees from greater than 400 species in response to limiting resources in the tropical forests of Panama. In contrast to theoretical expectations of the growth–mortality paradigm, we find that tropical tree species restricted to low-phosphorus soils simultaneously achieve faster growth rates and lower mortality rates than species restricted to high-phosphorus soils. This result demonstrates that adaptation to phosphorus limitation in diverse plant communities modifies the growth–mortality trade-off, with important implications for understanding long-term ecosystem dynamics.