Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of CYP2C19 Polymorphism on Endothelial Function, Arterial Stiffness and Inflammation in Coronary Artery Disease Patients Under Clopidogrel Treatment.

BACKGROUND Clopidogrel's ability to inhibit platelet function determined its clinical usefulness. The role of CYP2C19*2 genotype on antiplatelet treatment is recently under question. Arterial wall properties and inflammation are key players in atherosclerosis development. Hence, we evaluated the impact of CYP2C19*2 genetic polymorphism on endothelial function, arterial stiffness and inflammation in coronary artery disease (CAD) patients receiving clopidogrel treatment. METHODS AND RESULTS In this study we enrolled 408 consecutive patients with stable CAD under dual antiplatelet therapy (clopidogrel 75mg/day, aspirin 100mg/day), 30 days after percutaneous coronary intervention. Measurement of flow-mediated dilation (FMD) of the brachial artery was used to evaluate endothelial function. Carotid-femoral pulse wave velocity (PWV) and augmentation index (AIx) was measured to estimate arterial stiffness. Real time polymerase chain reaction was used for the genotyping of CYP2C19*2. Levels of tumor necrosis factor alpha (TNF-a) and interleukin 6 (IL-6) were measured with ELISA. We found no difference in basic clinical and demographic characteristics nor in FMD, PWV, AIx and inflammatory status (p=NS for all) between CYP2C19 homozygotes for the wild type; carriers of reduced function allele and homozygotes for the reduced function allele. CONCLUSION CYP2C19*2 loss of action polymorphism causes no impact on vascular function and inflammatory status in stable CAD patients receiving clopidogrel treatment.
Most New Businesses Fail, but Mine Won’t…Right?

Building on expectancy theory, we study why entrepreneurs form positive beliefs about, and subsequent commitments to, entrepreneurial actions despite the negative mean outcome observed in the history of entrepreneurial efforts. We test our model using structural equation modelling on a sample of 1,185 entrepreneurs derived from the Panel Study of Entrepreneurial Dynamics II (PSED II) database. We find that the perceived gap between the value of an opportunity and opportunity cost positively influences both entrepreneurial expectancy and entrepreneurial intensity. Further, we find that the strength of these relationships is contingent upon uncertainty preference. Together, these findings contribute to literature on expectancy theory, increase our understanding of the role of uncertainty in entrepreneurial cognition and suggest that entrepreneurs’ cognition may be more rational than surface level appearances suggest.
One step feature extraction and classification with Tikhonov regularization for BCI

The Common Spatial Patterns algorithm is a highly successful feature extraction algorithm used in classification of motor imagery signals in brain computer interface. For short data sets and noise contaminated data sets Tikhonov regularized variant of CSP is better. Both the methods are followed by a feature classification stage, usually Linear Discriminant Analysis. Here a one step feature extraction and classification for Tikhonov regularized common spatial pattern (CSP) is proposed, where the features are automatically learned, selected and combined through a convex optimization problem. The method reduces over fitting and sensitivity to noise contaminated signals.
Personalized Extended Government for Local Public Administrations

This paper discusses the enterprise organization environment and reports our experience and lessons learned in developing an extension of the traditional virtual enterprise model, we named personalized extended government (PEG) model. The aim of such model is to simplify and enhance the effectiveness of e-Government services, by realizing Administration to Administration (A2A) and Administration to Citizen (A2C) processes in a personalized perspective. The features of the proposed model make it suitable for use in local public administrations. As a proof of this, it has been successfully deployed to realize the Italian Open Government Data Portal of Regione Lazio, which allows every citizen to be informed about the employment of public resources on regional
Spectrum Handoff for Cognitive Radio Systems Based on Prediction Considering Cross-Layer Optimization

The spectrum handoff problem for cognitive radio systems is considered in this paper. The secondary users (SUs) can only opportunistically access the spectrum holes, i.e. the frequency channels unoccupied by the primary users (PUs). As long as a PU appears, SUs have to vacate the channel to avoid interference to PUs and switch to another available channel. In this paper, a prediction-based spectrum handoff scheme is proposed to reduce the negative effect (both the interference to PUs and the service block of SUs) during the switching time. In the proposed scheme, a hidden Markov model is used to predict the occupancy of a frequency channel. By estimating the state of the model in the next time instant, we can predict whether the frequency channel will be occupied by PUs or not. As a cross-layer design, the spectrum sensing performance parameters false alarm probability and missing detection probability are taken into account to enhance accuracy of the channel occupancy prediction. The proposed scheme will react on the spectrum sensing algorithm parameters while the spectrum handoff performance is significantly affected by them. The interference to the PUs could be reduced obviously by adapting the proposed spectrum handoff scheme, associated with a potential increase of switch delay of SUs. It will also be helpful for SUs to save broadband scan time and prefer an appropriate objective channel so as to avoid service block. Numerical results demonstrate the above performance improvement by using this prediction-based scheme.
Optimal Signal Processing in Ground-Based Forward Scatter Micro Radars

The received signal in forward scatter radar (FSR) depends on the target's electrical size and trajectory, which are unknown a priori. As a result, in practical situations, it is impossible to obtain the accurate reference function at the reception side, and adaptation of optimal filtering is therefore proposed for this case. This paper presents a signal processing algorithm for ground target detection using FSR, which includes the construction of the adaptive reference functions and the identification of target velocity and its observation time. Furthermore, the algorithm performance is analytically determined under practical motion trajectories such as different motion directions and baseline crossing points, which indicate the effectiveness of the proposed algorithm in a practical case for FSR. The effectiveness of the algorithm is shown using both simulated and experimental data. Finally, the resolution in convoy targets in ground-based FSR is analytically obtained for the first time; the resolution is totally different from the resolution in conventional radar theory because of the target signature characteristics in ground-based FSR. The majority of the analytical results are verified experimentally.
The vasodilator action of nebivolol in forearm vasculature of subjects with essential hypertension.

AIMS Brachial artery administration of nebivolol increases forearm blood flow in normotensive subjects through activation of the L-arginine/NO pathway. The aim of the present study was to investigate the effect of brachial artery administration of nebivolol in subjects with essential hypertension. METHODS We studied eight patients with uncomplicated essential hypertension and serum cholesterol less than 6.9 mmol l-1. Antihypertensive medication was discontinued 2 weeks before the study in previously treated patients. Following cannulation of the left brachial artery, saline was infused to establish baseline blood flow, followed by increasing doses of nebivolol (88.5, 177 and 354 microg min-1, each dose for 6 min), followed by saline for 12 min, followed by a 30 min infusion of L-NMMA (2 mg min-1 ). During the final 18 min of the L-NMMA infusion, nebivolol was coinfused using the same doses as before. Forearm blood flow was measured in both arms using venous occlusion plethysmography. RESULTS Blood flow in the noninfused arm did not change significantly throughout the study. In the infused arm blood flow increased significantly in a dose-related manner during the first series of nebivolol infusions from 2.76+/-0.39 ml min-1-1 100 ml forearm-1 during the baseline period to 4.40+/-0.60 ml min-1-1 100 ml forearm-1 (mean+/-s.e. mean, n=8, P=0.0003 by anova ). L-NMMA antagonized the vasodilator effect of nebivolol: baseline blood flow in the infused arm was 2.41+/-0.53 ml min-1 100 ml forearm-1 and 2.94+/-0.42 ml min-1 100 ml forearm-1 during coinfusion of the top dose of nebivolol with L-NMMA (P=0.0006 for an effect of L-NMMA on nebivolol response). There were no serious adverse events. CONCLUSIONS Nebivolol causes vasodilation in the forearm vascular bed in subjects with essential hypertension. Since this response is antagonized by L-NMMA, the vasodilatation is probably caused by activation of the L-arg/NO pathway.
Interactive Visualization of Generalized Virtual 3D City Models using Level‐of‐Abstraction Transitions

Virtual 3D city models play an important role in the communication of complex geospatial information in a growing number of applications, such as urban planning, navigation, tourist information, and disaster management. In general, homogeneous graphic styles are used for visualization. For instance, photorealism is suitable for detailed presentations, and non‐photorealism or abstract stylization is used to facilitate guidance of a viewer's gaze to prioritized information. However, to adapt visualization to different contexts and contents and to support saliency‐guided visualization based on user interaction or dynamically changing thematic information, a combination of different graphic styles is necessary. Design and implementation of such combined graphic styles pose a number of challenges, specifically from the perspective of real‐time 3D visualization. In this paper, the authors present a concept and an implementation of a system that enables different presentation styles, their seamless integration within a single view, and parametrized transitions between them, which are defined according to tasks, camera view, and image resolution. The paper outlines potential usage scenarios and application fields together with a performance evaluation of the implementation.
Augmented social cognition: using social web technology to enhance the ability of groups to remember, think, and reason

We are experiencing a new Social Web, where people share, communicate, commiserate, and conflict with each other. As evidenced by systems like Wikipedia, twitter, and delicious.com, these environments are turning people into social information foragers and sharers. Groups interact to resolve conflicts and jointly make sense of topic areas from "Obama vs. Clinton" to "Islam. " PARC's Augmented Social Cognition researchers -- who come from cognitive psychology, computer science, HCI, CSCW, and other disciplines -- focus on understanding how to "enhance a group of people's ability to remember, think, and reason". Through Social Web systems like social bookmarking sites, blogs, Wikis, and more, we can finally study, in detail, these types of enhancements on a very large scale. Here we summarize recent work and early findings such as: (1) how conflict and coordination have played out in Wikipedia, and how social transparency might affect reader trust; (2) how decreasing interaction costs might change participation in social tagging systems; and (3) how computation can help organize user-generated content and metadata.
Emerging from the shadows? Perceptions, problems and potential consensus on the functional and civic roles of public affairs practice

In the context of public concern and negative media portrayals in regard to the civic impact of the public relations specialism of public affairs and lobbying, this article seeks to theorise normative roles in democracies alongside benchmarking the self-perception of practitioners against those of opinion forming elites. The article also explores how practitioners interpret their roles and locates a consensus in regard to their functional and civic contributions. A potential research agenda for testing the validity of these claims of a positive civic contribution is discussed. The article analyses the results of quantitative surveys of a representative sample of British members of parliament, and 722 UK opinion formers, plus 260 interviews with opinion formers in Washington DC. The results were complemented by a Delphi survey of UK public affairs practitioners that sought to identify and test areas of consensus in regard to both organisational and civic functions. The research finds that lobbying is perceived as legitimate by elites, but there are concerns over the quality of the information subsidy that is provided. Practitioners share an understanding with the public relations literature of their functional roles, and believe they make a social contribution by assisting policy-making, connecting society to politicians and as facilitators of participation and civic dialogue. This research will potentially be less applicable to the relationship between public affairs and society in other regions of the world, or in authoritarian states with low levels of interest group pluralism.
Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1

In this study, insulin receptor substrate (IRS) p53 is identified as a binding partner for Kank, a kidney ankyrin repeat–containing protein that functions to suppress cell proliferation and regulate the actin cytoskeleton. Kank specifically inhibits the binding of IRSp53 with active Rac1 (Rac1G12V) but not Cdc42 (cdc42G12V) and thus inhibits the IRSp53-dependent development of lamellipodia without affecting the formation of filopodia. Knockdown (KD) of Kank by RNA interference results in increased lamellipodial development, whereas KD of both Kank and IRSp53 has little effect. Moreover, insulin-induced membrane ruffling is inhibited by overexpression of Kank. Kank also suppresses integrin-dependent cell spreading and IRSp53-induced neurite outgrowth. Our results demonstrate that Kank negatively regulates the formation of lamellipodia by inhibiting the interaction between Rac1 and IRSp53.
Psychometrics of a new questionnaire to assess glaucoma adherence: the Glaucoma Treatment Compliance Assessment Tool (an American Ophthalmological Society thesis).

PURPOSE To report the psychometrics of the Glaucoma Treatment Compliance Assessment Tool (GTCAT), a new questionnaire designed to assess adherence with glaucoma therapy. METHODS We developed the questionnaire according to the constructs of the Health Belief Model. We evaluated the questionnaire using data from a cross-sectional study with focus groups (n = 20) and a prospective observational case series (n=58). Principal components analysis provided assessment of construct validity. We repeated the questionnaire after 3 months for test-retest reliability. We evaluated predictive validity using an electronic dosing monitor as an objective measure of adherence. RESULTS Focus group participants provided 931 statements related to adherence, of which 88.7% (826/931) could be categorized into the constructs of the Health Belief Model. Perceived barriers accounted for 31% (288/931) of statements, cues-to-action 14% (131/931), susceptibility 12% (116/931), benefits 12% (115/931), severity 10% (91/931), and self-efficacy 9% (85/931). The principal components analysis explained 77% of the variance with five components representing Health Belief Model constructs. Reliability analyses showed acceptable Cronbach's alphas (>.70) for four of the seven components (severity, susceptibility, barriers [eye drop administration], and barriers [discomfort]). Predictive validity was high, with several Health Belief Model questions significantly associated (P <.05) with adherence and a correlation coefficient (R (2)) of . 40. Test-retest reliability was 90%. CONCLUSION The GTCAT shows excellent repeatability, content, construct, and predictive validity for glaucoma adherence. A multisite trial is needed to determine whether the results can be generalized and whether the questionnaire accurately measures the effect of interventions to increase adherence.
A Collaborative Environment for Urban Landscape Simulation

Digital maps are very commonly used in the analysis, administration and representation of urban spaces. Despite the degree of information they can provide, they still pose some difficulties in decision making due to the three-dimensional nature of such ever-changing settings. This paper presents a collaborative solution for large virtual environment recreation aimed at urban landscape simulation. By providing an extensive interactive three-dimensional virtualization of a real-world city, multiple users may contribute with additional data, to either improve the model fidelity or to preview the impact of certain urban changes. This is achieved by employing procedural modeling methods to generate a basic three-dimensional city model from real-world data and a set of parameters, which can later be refined through human intervention. A multi-user simulation platform has been conceived, allowing the collaborative management of the model data, as well as the simulation of possible urban landscape changes, introducing therefore more advanced analysis and representation features to study and discuss the impact of certain decisions on the urban landscape.
Perceptual Consequences of “Hidden” Hearing Loss

Dramatic results from recent animal experiments show that noise exposure can cause a selective loss of high-threshold auditory nerve fibers without affecting absolute sensitivity permanently. This cochlear neuropathy has been described as hidden hearing loss, as it is not thought to be detectable using standard measures of audiometric threshold. It is possible that hidden hearing loss is a common condition in humans and may underlie some of the perceptual deficits experienced by people with clinically normal hearing. There is some evidence that a history of noise exposure is associated with difficulties in speech discrimination and temporal processing, even in the absence of any audiometric loss. There is also evidence that the tinnitus experienced by listeners with clinically normal hearing is associated with cochlear neuropathy, as measured using Wave I of the auditory brainstem response. To date, however, there has been no direct link made between noise exposure, cochlear neuropathy, and perceptual difficulties. Animal experiments also reveal that the aging process itself, in the absence of significant noise exposure, is associated with loss of auditory nerve fibers. Evidence from human temporal bone studies and auditory brainstem response measures suggests that this form of hidden loss is common in humans and may have perceptual consequences, in particular, regarding the coding of the temporal aspects of sounds. Hidden hearing loss is potentially a major health issue, and investigations are ongoing to identify the causes and consequences of this troubling condition.
Recovery of Sparse and Low Rank Components of Matrices Using Iterative Method with Adaptive Thresholding

In this letter, we propose an algorithm for recovery of sparse and low rank components of matrices using an iterative method with adaptive thresholding. In each iteration, the low rank and sparse components are obtained using a thresholding operator. This algorithm is fast and can be implemented easily. We compare it with one of the most common fast methods in which the rank and sparsity are approximated by $\ell_1$ norm. We also apply it to some real applications where the noise is not so sparse. The simulation results show that it has a suitable performance with low run-time.
What computers still can't do - a critique of artificial reason

From the Publisher: When it was first published in 1972, Hubert Dreyfus's manifesto on the inherent inability of disembodied machines to mimic higher mental functions caused an uproar in the artificial intelligence community. The world has changed since then. Today it is clear that "good old-fashioned AI," based on the idea of using symbolic representations to produce general intelligence, is in decline (although several believers still pursue its pot of gold), and the focus of the Al community has shifted to more complex models of the mind. It has also become more common for AI researchers to seek out and study philosophy. For this edition of his now classic book, Dreyfus has added a lengthy new introduction outlining these changes and assessing the paradigms of connectionism and neural networks that have transformed the field. At a time when researchers were proposing grand plans for general problem solvers and automatic translation machines, Dreyfus predicted that they would fail because their conception of mental functioning was naive, and he suggested that they would do well to acquaint themselves with modern philosophical approaches to human beings. What Computers Can't Do was widely attacked but quietly studied. Dreyfus's arguments are still provocative and focus our attention once again on what it is that makes human beings unique. Hubert L. Dreyfus, who is Professor of Philosophy at the University of California, Berkeley, is also the author of Being-in-the-World. A Commentary on Heidegger's Being and Time, Division I.
The modulating effects of propofol and its lipid carrier on canine neutrophil functions

Propofol (2,6-diisopropylphenol), being used as an intravenous sedative and anesthetic agent, influences not only upon nervous system but also for host inflammatory response through modulating neutrophil functions. This study is designed to evaluate the modulating effects of propofol and its lipid carrier administration at clinically relevant rate on canine neutrophil functions. Clinically healthy beagle dogs were received propofol (8.8 mg/kg) from cephalic vein and maintained with propofol dropping infusion (26.4 mg/kg/hr). Blood samples were collected from the dogs before infusion and 30 min after the start of propofol administration, and neutrophil functions were evaluated. The dogs were also administered lipid carrier, and neutrophil functions were evaluated in the same manner as propofol administration. Peripheral white blood cell and neutrophil counts decreased after the propofol or lipid carrier administration. The administration of propofol or lipid carrier significantly reduced neutrophil adherence ability. The superoxide production of neutrophils was measured by luminol-dependent chemiluminescence response using with opsonized zymosan. Peak height of neutrophil chemiluminescence curve was reduced by propofol and lipid carrier administration, on the contrary, peak time of neutrophil chemiluminescence curve was delayed. Administration of propofol or lipid carrier also reduced neutrophil adherence ability to nylon fibers. In the present study, we showed the modulating effects of propofol and its lipid carrier on canine neutrophil functions. However, there was no significant difference in the modulating effects between propofol group and lipid carrier group. Therefore, the modulating effects observed here were deeply concerned in lipid carrier administration.