Miracle-dz/UniFAR-FTUs huggingface dataset:
Some observations on prope tolerance

Purpose of reviewTo outline the rationale of powerful depleting induction therapy with alemtuzumab and minimal maintenance immunosuppression after organ transplantation. Recent findingsThe original observations in principle have been confirmed by many independent centres. SummaryFollow-up of the ‘prope tolerance’ protocol has confirmed a low incidence of rejection, infection and post transplant lymphoproliferative disorder (PTLD). Especially, encouraging results were obtained in African-Americans. There were few side effects and the regimen was well tolerated by patients. Treg cells were observed in the circulation, which could be an important factor in the mechanisms of graft acceptance using a prope tolerance regimen. There was a considerable reduction in the costs of the transplantation procedure. It is suggested that this minimalisation of maintenance immunosuppression is the best therapy currently available that we can offer to our patients.
Testing the DGP model with gravitational lensing statistics

Aims. The self-accelerating braneworld model (DGP) appears to provide a simple alternative to the standard ΛCDM cosmology to explain the current cosmic acceleration, which is strongly indicated by measurements of type Ia supernovae, as well as other concordant observations. Methods. We investigate observational constraints on this scenario provided by gravitational-lensing statistics using the Cosmic Lens All-Sky Survey (CLASS) lensing sample. Results. We show that a substantial part of the parameter space of the DGP model agrees well with that of radio source gravitational lensing sample. Conclusions. In the flat case, ΩK = 0, the likelihood is maximized, L = Lmax ,f orΩM = 0.30 +0.19 −0.11 . If we relax the prior on ΩK ,t he likelihood peaks at {ΩM, Ωrc }�{ 0.29, 0.12}, slightly in the region of open models. The confidence contours are, however, elongated such that we are unable to discard any of the close, flat or open models.
Configuration et exploitation d'une machine émotionnelle

This paper explores the feasibility of equipping computers with the ability to predict, in a context of a human computer interaction, the probable user’s emotion and its intensity for a wide variety of emotion-eliciting situations. More specifically, an online framework, the Emotional Machine, is developed enabling computers to «understand» situations using OCC model of emotion and to predict user’s reaction by combining refined versions of Artificial Neural Network and k Nearest Neighbours algorithms. An empirical procedure including a web-based anonymous questionnaire for data acquisition was designed to provide the chosen machine learning algorithms with a consistent knowledge and to test the application’s recognition performance. Results from the empirical investigation show that the proposed Emotional Machine is capable of producing accurate predictions. Such an achievement may encourage future using of our framework for automated emotion recognition in various application fields.
The Role of SF2 in Prostate Cancer Progression

Abstract : Background: Prostate cancer (PCa), a leading cause of male mortality, development and progression is dependent upon androgen and androgen receptor (AR) signaling. Current therapies target androgen production and/or AR signaling. Evidence suggests that AR in some tumors may escape therapy through mechanisms that likely involve splicing. Purpose: To better understand splicing during PCa development or progression. Scope: Observations suggest that the splicing factor (SF2) may contribute to PCa. Findings: i) IHC analysis, suggests SF2 is elevated in human PCa specimens, ii) PCa-derived cell model systems with altered levels of SF2 that mimic human disease, suggests proliferative phenotype, iii) Knockdown of SF2, suggests PCa-specific splicing. Recent progress: i) Immunoblot analysis of SF2 in primary PCa tissue lysates validated IHC findings, ii) Knockdown of SF2 promotes G2/M arrest, iii) Tissue recombination assays yielded no identifiable glandular structures, iv) An ex vivo primary PCa culture system was developed to evaluate future splicing and therapeutic potential.
The urban employment matching decision-making of rural migrant workers based on grey incidence analysis

With the accelerating process of urbanization, rural migrant workers flood into the cities. Research projects that aim at resettlement and employment promotion of these workers, social stability, as well as economic development have drawn attention of government and scholars alike. With respect to the matching problems of urban employment of rural migrant workers, grey incidence analysis and two-sided matching theory is exploited to establish a novel two-sided matching decision-making model between rural workers and their jobs. In this paper, first, grey incidence analysis is used to describe and measure the preference information and satisfaction degree of both rural workers and their jobs; from the perspective of satisfaction degree of matching subjects, stability of the matching plan and equality, a multi-objective optimization model for two-sided matching decision-making problem between rural workers and their jobs was constructed, based on minimum matching distance and minimum deviation of matching distance; then linear weighting method is exploited to convert the multi-objective matching model into a single-objective optimization model to determine the two-sided matching plan between rural workers and their jobs; finally, the real problem of urban employment of rural migrant workers is discussed.
An Ethnographic Perspective

T HESE CONTRIBUTIONS are linked by the question "Is there a universal basis for the notion of literature? " In varying degree, they suggest strategies for answering the question. These issues are in principle part of a general inquiry into the nature and organization of the means of speech in human communities, and their meanings to those who use them, an inquiry being pursued with increasing vigor by participants of many disciplines. ' The ethnographic approach on which I shall draw is not as rich in known content as literary criticism, but it has an indispensable place, as I shall try to show. At the end I shall argue that literary criticism has in turn an indispensable place in ethnography. I shall begin and end with articles in alphabetical order of their authors' names, because, as it happens, these give me the frame within which I can consider the rest.
Prognostic value of cardiac troponin T elevation is independent of renal function and clinical findings in heart failure patients.

BACKGROUND The aim of this study is to determine the prevalence and prognostic value of elevated cardiac troponin (cTnT) and its association with clinical characteristics according to renal function status in patients with stable heart failure. METHODS In a prospective observational study, 152 consecutive patients from the Heart Failure Clinic of the INCMNSZ were followed for a period of 42 months. All underwent clinical evaluation, echocardiography, and determination of body composition by electric bioimpedance to identify hypervolemia. Concentrations of cTnT were quantified by immunoassay with electrochemoluminescence and > or = 0.02 ng/mL levels were considered elevated. Also glomerular filtration rate (eGFR) was estimated using the Cockcroft-Gault equation. RESULTS Elevated cTnT was significantly associated with increased all-cause mortality in the observational period even after adjusting for eGFR < 60 mL/min/1.73 m2 and clinical findings such as hypertension, functional class, loop diuretics, angiotensin converting enzyme inhibitors, pulmonary pressure and hypervolemia in Cox regression analysis with a hazard ratio of 4.58 (95% confidence interval: 1.84-11.45). CONCLUSIONS Heart failure patients with elevated cardiac-specific troponin T are at increased risk of death independently of the presence of chronic kidney disease.
Nutritional Support in Dysphagia

Dysphagia is defined as difficulty in swallowing. It is commonly caused due to neuromuscular (stroke, dementia, Parkinson’s disease, myasthenia gravis, etc.), mechanical (oral cancer, oesophageal cancer, etc.), or other causes (radiotherapy treatment, gastroesophageal reflux disease, thrush, etc.). It risks aspiration and associated bronchopulmonary infections, fluid depletion, and under nutrition. It can alter nutritional equilibrium and can affect organ function and ultimately clinical outcome. To improve clinical outcomes, it is important to screen all at risk patients in order to identify patients at nutritional risk due to dysphagia [1– 4]. Most dysphagia resolves within few weeks, but in some cases it may persist. This may affect the nutritional state of the individual who is already facing an illness or injury in first instance [5, 6]. Dysphagia and accompanying malnutrition is associated with excess morbidity and increased mortality rates [7, 8]. This chapter will focus on general principles of nutritional management in any patient including patients with dysphagia.
Looking to the Future: A Case Study-Driven Insight into Pedagogical Strategies to Motivate and Guide Students with Asperger's Syndrome through Their Dissertation

This paper reports a case study which offers insights into the complexities of supervising a student with Asperger’s syndrome through his undergraduate dissertation. It highlights certain problems with the dissertation, which are significant to Asperger’s syndrome, and begins to look into pedagogical and assessment strategies that can be put in place to address these issues. A Brief Introduction to Asperger’s Syndrome
The Effects of Incline and Level-Grade High-Intensity Interval Treadmill Training on Running Economy and Muscle Power in Well-Trained Distance Runners

Abstract Ferley, DD, Osborn, RW, and Vukovich, MD. The effects of incline and level-grade high-intensity interval treadmill training on running economy and muscle power in well-trained distance runners. J Strength Cond Res 28(5): 1298–1309, 2014—Despite a paucity of evidence, uphill running has been touted as a sport-specific resistance-to-movement training tactic capable of enhancing metabolic, muscular, and neuromuscular processes in distance runners in ways similar to previously established resistance-to-movement training methods, such as heavy and/or explosive strength training and plyometric training. Therefore, the purpose of this investigation included documenting the effects of incline and level-grade interval treadmill training on indices of running economy (RE) (i.e., oxygen consumption [V[Combining Dot Above]O2] and blood lactate [BLa] responses of submaximal running) and muscle power. Thirty-two well-trained distance runners (age, 27.4 ± 3.8 years; body mass, 64.8 ± 8.9 kg; height, 173.6 ± 6.4 cm; and V[Combining Dot Above]O2max, 60.9 ± 8.5 ml·min−1·kg−1) received assignment to an uphill (GHill = 12), level-grade (GFlat = 12), or control (GCon = 8) group. GHill and GFlat completed 12 interval and 12 continuous run sessions over 6 weeks, whereas GCon maintained their normal training. Dependent variables measured before and after training were V[Combining Dot Above]O2 and BLa at 2 separate velocities associated with lactate threshold (VLT) (V[Combining Dot Above]O2-60% and V[Combining Dot Above]O2-80%; and BLa-60% and BLa-80%, respectively); percentage of V[Combining Dot Above]O2max at lactate threshold (%V[Combining Dot Above]O2max at VLT); muscle power as assessed through a horizontal 5-jump test (5Jmax); and isokinetic knee extension and flexion at 3 angular velocities (90, 180, and 300°·s−1). Statistical significance was set to p ⩽ 0.05. All groups significantly improved 5Jmax, V[Combining Dot Above]O2-60%, V[Combining Dot Above]O2-80%, BLa-60%, and BLa-80%. Additionally, GHill and GFlat significantly improved %V[Combining Dot Above]O2max at VLT. Other indices of RE and muscle power did not improve. We conclude incline treadmill training effective for improving the components of RE, but insufficient as a resistance-to-movement exercise for enhancing muscle power output.
Inverse targeting —An effective immunization strategy

We propose a new method to immunize populations or computer networks against epidemics which is more efficient than any continuous immunization method considered before. The novelty of our method resides in the way of determining the immunization targets. First we identify those individuals or computers that contribute the least to the disease spreading measured through their contribution to the size of the largest connected cluster in the social or a computer network. The immunization process follows the list of identified individuals or computers in inverse order, immunizing first those which are most relevant for the epidemic spreading. We have applied our immunization strategy to several model networks and two real networks, the Internet and the collaboration network of high-energy physicists. We find that our new immunization strategy is in the case of model networks up to 14%, and for real networks up to 33% more efficient than immunizing dynamically the most connected nodes in a network. Our strategy is also numerically efficient and can therefore be applied to large systems.
Seroepidemiological study of herpes simplex virus types 1 and 2 in Brazil, Estonia, India, Morocco, and Sri Lanka

Background: The association between herpes simplex virus type 2 (HSV-2) and human immunodeficiency virus (HIV) and the development of HSV vaccines have increased interest in the study of HSV epidemiology. Objectives: To estimate the age and sex specific seroprevalence of HSV-1 and HSV-2 infections in selected populations in Brazil, Estonia, India, Morocco, and Sri Lanka. Methods: Serum samples were collected from various populations including children, antenatal clinic attenders, blood donors, hospital inpatients, and HIV sentinel surveillance groups. STD clinic attenders were enrolled in Sri Lanka, male military personnel in Morocco. Sera were tested using a common algorithm by type specific HSV-1 and HSV-2 antibody assay. Results: 13 986 samples were tested, 45.0% from adult females, 32.7% from adult males, and 22.3% from children. The prevalence of HSV-1 varied by site ranging from 78.5%–93.6% in adult males and from 75.5%–97.8% in adult females. In all countries HSV-1 seroprevalence increased significantly with age (p<0.001) in both men and women. The prevalence of HSV-2 infection varied between sites. Brazil had the highest age specific rates of infection for both men and women, followed by Sri Lanka for men and Estonia for women, the lowest rates being found in Estonia for men and India for women. In all countries, HSV-2 seroprevalence increased significantly with age (p<0.01) and adult females had higher rates of infection than adult males by age of infection. Conclusions: HSV-1 and HSV-2 seroprevalence was consistently higher in women than men, particularly for HSV-2. Population based data on HSV-1 and HSV-2 will be useful for designing potential HSV-2 vaccination strategies and for focusing prevention efforts for HSV-1 and HSV-2 infection.
Intracranial stenting for nilotinib treatment-associated cerebrovascular stenosis in chronic myeloid leukemia

One of the second-generation tyrosine kinase inhibitors (TKIs), nilotinib, is increasingly used for imatinib-resistant or intolerant chronic myeloid leukemia (CML). Nilotinib is considered well tolerated with few side effects including hyperglycemia, hyperbilirubinemia and elevated levels of pancreatic enzymes. However, there is growing evidence that nilotinib accelerates atherosclerosis and causes peripheral arterial occlusive disease such as stroke, transient ischemic attack (TIA) and cardiovascular diseases. Herein, we report a case of a 74-year-old male CML patient with intracranial stenosis of the internal carotid artery developed during treatment with nilotinib successfully cured by the intracranial stent, Wingspan.
Optical effects of anti-TGFbeta treatment after photorefractive keratectomy in a cat model.

PURPOSE To assess the contribution of corneal myofibroblasts to optical changes induced by photorefractive keratectomy (PRK) in a cat model. METHODS The transforming growth factor (TGF)-beta-dependence of feline corneal keratocyte differentiation into alpha-smooth muscle actin (alphaSMA)-positive myofibroblasts was first tested in vitro. Twenty-nine eyes of 16 cats were then treated with -10 D PRK in vivo and divided into two postoperative treatment groups that received either 100 microg anti-TGFbeta antibody for 7 days, followed by 50 microg dexamethasone for another 7 days to inhibit myofibroblast differentiation, or vehicle solution for 14 days (control eyes). Corneal thickness and reflectivity were measured by optical coherence tomography. Wavefront sensing was performed in the awake-behaving state before surgery and 2, 4, 8, and 12 weeks after surgery. Wound healing was monitored using in vivo confocal imaging and postmortem alphaSMA immunohistochemistry. RESULTS In culture, TGFbeta caused cat corneal keratocytes to differentiate into alphaSMA-positive myofibroblasts, an effect that was blocked by coincubation with anti-TGFbeta antibody. In vivo, anti-TGFbeta treatment after PRK resulted in less alphaSMA immunoreactivity in the subablation stroma, lower corneal reflectivity, less stromal regrowth, and lower nonspherical higher order aberration induction than in control eyes. However, there were no intergroup differences in epithelial regeneration or lower order aberration changes. CONCLUSIONS Anti-TGFbeta treatment reduced feline corneal myofibroblast differentiation in vitro and after PRK. It also decreased corneal haze and fine-grained irregularities in ocular wavefront after PRK, suggesting that attenuation of the differentiation of keratocytes into myofibroblast can significantly enhance optical quality after refractive surface ablations.
Health and Disability Stress-related exhaustion disorder – clinical manifestation of burnout ?

GIORGIO GROSSI, ALEKSANDER PERSKI, WALTER OSIKA and IVANKA SAVIC Stress Research Institute, Stockholm University, Stockholm, Sweden The Stress Clinic Foundation, Stockholm, Sweden Center for Social Sustainability, Department of Neurobiology, Care Sciences and Society, Karolinska institute, Stockholm, Sweden Department of Women’s and Children’s Health, and Neurology Clinic, Karolinska Institute and Hospital, Stockholm, Sweden
A Framework for Schema Evolution by Meta Object Manipulation

In this paper we address the problem of schema evolution in object-oriented database systems. Most currently available database prototypes either completely lack schema evolution facilities, or ooer a restricted set of special purpose schema evolution operators supporting simple schema changes. Our approach is diierent. We consider schema objects as objects like others and have the meta schema fully available at run-time. Thus any operator of our object manipulation and query algebra can be applied to meta objects in the same way as they are used for data objects. We discuss the additional problems that arise when treating schema objects as normal objects and making the algebra work on the meta schema as well. Furthermore, we overview how to solve these problems on diierent levels of implementing schema evolution.
Crohn’s Is Not a 6-Week Disease: Lifelong Management of Mild to Moderate Crohn’s Disease

Crohn’s disease is an idiopathic, chronic inflammatory disorder of the digestive tract with heterogeneous clinical presentations. Crohn’s is currently not a curable disease, and patients are faced with a lifetime of recurrent disease flare-ups and remissions. Management strategies for Crohn’s must therefore be targeted toward lifelong management, taking into consideration not only the short-term but also the long-term aspects of the disease. With this in mind, here we review the classifications and natural history of Crohn’s disease and discuss possible predictive factors for the disease evolution in a patient. Here we also evaluate the current preferable treatment practices, based on scientifically valid research and collective clinical experience, for the management of mild to moderate Crohn’s disease.
Location of Disease in Patients Who Die From Endometrial Cancer: A Study of 414 Patients From a Single Institution

Objective The purpose of this study was to describe the location of disease at the time of death of patients with endometrial cancer who died of their disease. Methods All patients with a diagnosis of endometrial cancer from January 1993 through December 2010 were included. Histologic classification was either endometrioid or high-risk (HR) endometrial cancer. Patients who died were divided into 3 groups: dead of disease (DOD), dead of other causes (DOO), and dead lost to follow-up. Patterns of disease spread at death were documented from the most recent examination and imaging studies. Results We identified 2513 patients. The median age at diagnosis was 62 years. Histologic findings were endometrioid endometrial cancer, 1949 patients (78%); and HR endometrial cancer, 54 patients (22%). The 1988 International Federation of Gynecology and Obstetrics stages were: stage I, 1763 patients (70%); stage II, 145 patients (6%); stage III, 416 patients (17%); and stage IV, 189 patients (8%). At the time of this study, 1867 patients (74%) had no evidence of disease, 232 patients (9%) were alive with disease, and 414 patients (16%) were dead. Of the 16% of patients who were dead, 224 (9%) of the 2513 patients were DOD, 84 (3%) of the 2513 patients were dead of other disease, and 106 (4%) of the 2513 patients were dead lost to follow-up. Of the 224 patients who were DOD, the locations of the disease at the time of death were pelvic, 23 patients (10%); abdominal, 83 patients (37%); and distant, 118 patients (53%). There was no significant difference in the pattern of location of disease between the endometrioid and HR histologies (P = 0.36). Conclusions These data suggest that death from endometrial cancer is largely due to abdominal (liver) and distant (lung) metastases, and this pattern of disease seems similar in the endometrioid and HR histologies. Most of the patients who died of their disease had metastases beyond the pelvis at the time of death.
Energy Management in Wireless Mobile Systems Using Dynamic Task Assignment

Wireless mobile sensing systems are hierarchical and heterogeneous in nature with components that have different energy and performance capabilities. In such systems allocation of tasks to different devices affects both performance and the entire system battery lifetime. In this paper we formulate the problem of optimal task assignment with objectives related to minimizing the total system energy consumption and maximizing the system lifetime as an Integer Linear Program (ILP). We describe a heuristic algorithm and two dynamic graph-based partitioning algorithms that are computationally efficient and that are able to adapt in real-time to changing system conditions. ILP based solutions are able to achieve optimal task assignment, but cannot be used in dynamically changing conditions due to their computationally expensive nature. We evaluate the performance of our three dynamic algorithms using Qualnet and show that they have up to 88% longer system lifetime than the ILP based solutions.