Miracle-dz/UniFAR-FTUs huggingface dataset:
Pentablock copolymer based controlled release formulations of small and macromolecules for ophthalmic applications

Pentablock copolymers comprised of multi-polymer blocks such as polyethylene glycol (PEG), polycaprolactone (PCL) and poly-lactide (PLA) were developed for fabrication of nanoparticles and thermosensitive hydrogel formulations for long term delivery of small and macromolecules. Different pentablock copolymer compositions were evaluated to optimize drug release profile from nanoparticles and thermosensitive gel formulations. Our composite approach i.e. pentablock copolymers based nanoparticles suspended in thermosensitive gel provided sustained zero-order delivery of encapsulated therapeutic agents without producing any significant burst effect. Different compositions of pentablock copolymers (polylatidepolycaprolactonepolyethylene glycolpolycaprolactonepolylatide) (PLA-PCL-PEG-PCL-PLA) and (PEGPCL-PLA-PCL-PEG) were synthesized and characterized to prepare nanoparticle and thermosensitive hydrogel formulations, respectively. The effect of poly (L-lactide) (PLLA) or poly (D, L-lactide) (PDLLA) incorporation on crystallinity of pentablock copolymers and in vitro release profile of triamcinolone acetonide (selected as model drug) from nanoparticles was also evaluated. Pentablock polymer with proper ratio PDLLA/PCL was amorphous in nature whereas PLLA containing polymer has semicrystalline nature. Release of triamcinolone acetonide from nanoparticles was significantly affected by crystallinity of the copolymers. Burst release of triamcinolone acetonide from nanoparticles was significantly minimized with incorporation of proper ratio of PDLLA in the existing triblock (PCL-PEG-PCL)
Effect of path diversity on the loss performance of UDP packets over the internet

In this paper we investigate the effect of path diversity on the packet loss performance through simulations and experiments using three overlay networks created on top of the PlanetLab testbed. The overlay network consists of a number of relay nodes that are positioned around the Internet. In each of the overlay networks UDP packets are streamed from a client to a destination for a period of 50 days, across up to six paths with a static packet dispatching algorithm. From the results obtained, we can see that increasing the number of paths could increase as well as decrease the packet loss probability, depending on the network environment and the structure of the multiple paths created. We have also investigated the correlation in the underlying network and demonstrated the performance of the metric defined.
Synthesis of copper alloys with extended solid solubility and nano Al2O3 dispersion by mechanical alloying and equal channel angular pressing

Cu–4.5 wt % Cr and Cu–4.5 wt % Cr–3 wt % Ag alloys, with and without nanocrystalline Al2O3 dispersions (particle size <10 nm), were synthesized by mechanical alloying/milling and consolidated by equal-channel angular pressing (ECAP) at ambient temperature. Microstructural characterization and phase analysis by X-ray diffraction, as well as scanning and transmission electron microscopy, provided evidence for the formation of a Cu-rich extended solid solution with nanometric (<30 nm) crystallite size after 25 h of milling, with uniformly dispersed alumina nanoparticles embedded in it. Consolidation of Cu–4.5 wt % Cr–3 wt % Ag alloy with 10 wt % nanocrystalline Al2O3 by eight ECAP passes was shown to result in a composite with an exceptionally large hardness of 390 VHN and enhanced wear resistance. The electrical conductivity of the pellets of the latter alloy without Al2O3 is about 30% IACS (international annealing copper standard), whereas pellets with 5 or 10 wt % Al2O3 dispersion exhibit a conductivity of about 20–25% IACS. Thus, the present room temperature synthesis and consolidation route appear to offer a promising avenue for developing high-strength, wear/erosion-resistant Cu-based electrical contacts with nano-ceramic dispersion.
Understanding recreational fishers' compliance with no-take zones in the Great Barrier Reef Marine Park

Understanding fishers' compliance is essential for the successful management of marine protected areas. We used the random response technique (RRT) to assess recreational fishers' compliance with no-take zones in the Great Barrier Reef Marine Park (GBRMP). The RRT allowed the asking of a sensitive question, i.e., "Did you, knowingly, fish within in a Green Zone during the last 12 months? " while protecting respondents' confidentiality. Application of the RRT through a survey of recreational fishers indicated that the majority of recreational fishers, 90%, comply with no-take zones. Likewise, most fishers, 92%, reported not personally knowing anyone who had intentionally fished in a no-take zone, indicating that fishers' perceive high levels of compliance among their peers. Fishers were motivated to comply with no-take zones primarily by their beliefs about penalties for noncompliance, followed by beliefs about the fishery benefits of no-take zones. Results suggest that compliance-related communication efforts by the managing authority have partially succeeded in maintaining appropriate compliance levels and that future efforts should accentuate normative compliance drivers that will encourage voluntary compliance. We conclude that compliance monitoring should be integrated into the adaptive management of the GBRMP and other protected areas; in this case social surveys using the RRT are effective tools.
[Renal inflammatory pseudotumor manifesting as a prolonged fever].

INTRODUCTION Inflammatory pseudo-tumors (IPT) are benign neoplasms associated with local or general manifestations. Renal localization seems exceptional, and no case of fever of unknown origin caused by renal inflammatory pseudo-tumors have been reported. EXEGESIS The authors report the case of a man presenting fever of unknown origin and inflammatory syndrome. Computerized tomography showed a renal mass. Nephrectomy was performed, and renal inflammatory pseudo-tumor was diagnosed. After surgical exeresis, the clinical and biological abnormalities vanished. CONCLUSION This rare diagnosis must be considered in these situations. The outcome is excellent.
ANGIE: Active Knowledge for Interactive Exploration

We present ANGIE, a system that can answer user queries by combining knowledge from a local database with knowledge retrieved from Web services. If a user poses a query that cannot be answered by the local database alone, ANGIE calls the appropriate Web services to retrieve the missing information. This information is integrated seamlessly and transparently into the local database, so that the user can query and browse the knowledge base while appropriate Web services are called automatically in the background.
Statin (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor)-based therapy for hepatitis C virus (HCV) infection-related diseases in the era of direct-acting antiviral agents

Recent improvements have been made in the treatment of hepatitis C virus (HCV) infection with the introduction of direct-acting antiviral agents (DAAs). However, despite successful viral clearance, many patients continue to have HCV-related disease progression. Therefore, new treatments must be developed to achieve viral clearance and prevent the risk of HCV-related diseases. In particular, the use of pitavastatin together with DAAs may improve the antiviral efficacy as well as decrease the progression of liver fibrosis and the incidence of HCV-related hepatocellular carcinoma. To investigate the management methods for HCV-related diseases using pitavastatin and DAAs, clinical trials should be undertaken. However, concerns have been raised about potential drug interactions between statins and DAAs. Therefore, pre-clinical trials using a replicon system, human hepatocyte-like cells, human neurons and human cardiomyocytes from human-induced pluripotent stem cells should be conducted. Based on these pre-clinical trials, an optimal direct-acting antiviral agent could be selected for combination with pitavastatin and DAAs. Following the pre-clinical trial, the combination of pitavastatin and the optimal direct-acting antiviral agent should be compared to other combinations of DAAs ( e.g., sofosbuvir and velpatasvir) according to the antiviral effect on HCV infection, HCV-related diseases and cost-effectiveness.
Traffic engineering in metro Ethernet

Traffic engineering is a critical issue that has to be addressed in metro Ethernet networks for proper and efficient resource utilization as well as facilitating quality of service. This article aims at understanding the relevant issues and outlines novel algorithms for multipoint-TE in the metro Ethernet. We first propose a grouping scheme that extends the current label space in the provider domain and allows for a large number of VLANs to be provisioned efficiently. Next, the issues of load balancing, multiple spanning trees, and interaction between grouping and bandwidth provisioning are discussed, and solutions are provided. Finally, we address differentiated survivability in next-generation Ethernet and provide a novel scheme based on multiple spanning trees. The schemes proposed in this article are shown to be scalable, bandwidth-efficient, and practical for both the customer and the provider.
A Neighbourhood-Based Stopping Criterion for Contrastive Divergence Learning

Restricted Boltzmann Machines (RBMs) are general unsupervised learning devices to ascertain generative models of data distributions. RBMs are often trained using the Contrastive Divergence learning algorithm (CD), an approximation to the gradient of the data log-likelihood. A simple reconstruction error is often used as a stopping criterion for CD, although several authors \cite{schulz-et-al-Convergence-Contrastive-Divergence-2010-NIPSw, fischer-igel-Divergence-Contrastive-Divergence-2010-ICANN} have raised doubts concerning the feasibility of this procedure. In many cases the evolution curve of the reconstruction error is monotonic while the log-likelihood is not, thus indicating that the former is not a good estimator of the optimal stopping point for learning. However, not many alternatives to the reconstruction error have been discussed in the literature. In this manuscript we investigate simple alternatives to the reconstruction error, based on the inclusion of information contained in neighboring states to the training set, as a stopping criterion for CD learning.
Nucleotide sequence of beet cryptic virus 3 dsRNA2 which encodes a putative RNA-dependent RNA polymerase.

The nucleotide sequence of a DNA copy of beet cryptic virus 3 double-stranded RNA2 was determined, and one strand was found to contain a single long open reading frame of 1431 nucleotides which encoded a putative polypeptide containing 478 amino acid residues with an M r of 54.9K. This polypeptide contained conserved amino acid sequence motifs found in the genes that encode putative RNA-dependent RNA polymerases of other RNA viruses.
Beam steering with pulsed two-dimensional transducer arrays

The major problem facing the development of 2-D arrays for imaging is the complexity arising from the large number of elements anticipated in such transducers. The authors have undertaken a theoretical investigation of the focusing and steering properties of pulsed 2-D arrays to characterize the parameters required for medical imaging, such as element size, spacing, and number of elements. Details of the computational methods employed are presented, as well as a discussion of the steered beam properties of wideband 2-D arrays. The effects of apodization and element cross-coupling on the beam properties of a 2-D transducer array are examined. The beam properties of various sparse arrays with elements randomly distributed over the aperture of the transducer are discussed. <<ETX>>
SICE: An Enhanced Framework for Design and Development of Speech Interfaces on Client Environment

VoiceXML has emerged as standard for developing IVRS based telephony applications. It provides the requisite robustness and control over dialogue based delivery over telephone line. This paper presents a framework based on VoiceXML specifications for developing web based interactive voice applications. Communications are made using VOIP; therefore, user does not have the dependency on telephony interface as required by existing VoiceXML specifications. Besides, it is able to handle the complex and voluminous information of web. The framework demonstrates the best practice of application design, development and software engineering.
What is open peer review? A systematic review

Background: “Open peer review” (OPR), despite being a major pillar of Open Science, has neither a standardized definition nor an agreed schema of its features and implementations. The literature reflects this, with numerous overlapping and contradictory definitions. While for some the term refers to peer review where the identities of both author and reviewer are disclosed to each other, for others it signifies systems where reviewer reports are published alongside articles. For others it signifies both of these conditions, and for yet others it describes systems where not only “invited experts” are able to comment. For still others, it includes a variety of combinations of these and other novel methods. Methods: Recognising the absence of a consensus view on what open peer review is, this article undertakes a systematic review of definitions of “open peer review” or “open review”, to create a corpus of 122 definitions. These definitions are systematically analysed to build a coherent typology of the various innovations in peer review signified by the term, and hence provide the precise technical definition currently lacking. Results: This quantifiable data yields rich information on the range and extent of differing definitions over time and by broad subject area. Quantifying definitions in this way allows us to accurately portray exactly how ambiguously the phrase “open peer review” has been used thus far, for the literature offers 22 distinct configurations of seven traits, effectively meaning that there are 22 different definitions of OPR in the literature reviewed. Conclusions: I propose a pragmatic definition of open peer review as an umbrella term for a number of overlapping ways that peer review models can be adapted in line with the aims of Open Science, including making reviewer and author identities open, publishing review reports and enabling greater participation in the peer review process.
Exploration of Chlamydial Type III Secretion System Reconstitution in Escherichia coli

Background Type III secretion system is a virulent factor for many pathogens, and is thought to play multiple roles in the development cycle and pathogenesis of chlamydia, an important human pathogen. However, due to the obligate intracellular parasitical nature of chlamydiae and a lack of convenient genetic methodology for the organisms, very limited approaches are available to study the chlamydial type III secretion system. In this study, we explored the reconstitution of a chlamydial type III secretion in Escherichia coli. Results We successfully cloned all 6 genomic DNA clusters of the chlamydial type III secretion system into three bacterial plasmids. 5 of the 6 clusters were found to direct mRNA synthesis from their own promoters in Escherichia coli transformed with the three plasmids. Cluster 5 failed to express mRNA using its own promoters. However, fusion of cluster 5 to cluster 6 resulted in the expression of cluster 5 mRNA. Although only two of the type III secretion system proteins were detected transformed E. coli due to limited antibody availability, type III secretion system-like structures were detected in ultrathin sections in a small proportion of transformed E. coli. Conclusions We have successfully generated E. coli expressing all genes of the chlamydial type III secretion system. This serves as a foundation for optimal expression and assembly of the recombinant chlamydial type III secretion system, which may be extremely useful for the characterization of the chlamydial type III secretion system and for studying its role in chlamydial pathogenicity.
Improved Reachability Analysis for Security Management

Network reachability analysis evaluates the actual connectivity of an IT infrastructure. It can be performed by active network probing or examining a formal model of a target IT infrastructure. The latter approach is preferable as it does not interfere with the normal network behaviour and can be easily used during development and change management phases. In this paper we propose a novel modelling approach based on a geometric representation of device configurations (i.e. the policies) which allows the computation of the reachability analysis using the concept of equivalent firewall. An equivalent firewall is a fictitious device, ideally connected directly to the communication endpoints, that summarizes the network behaviour between them. Our model supports routing, filtering and address translation devices in a computationally effective way. In fact, the experimental results show that the computation of equivalent firewalls is performed in a negligible time and that then the reachability queries are answered in few seconds.
Activation of Natural Killer T Cells by -Galactosylceramide Rapidly Induces the Full Maturation of Dendritic Cells In Vivo and Thereby Acts as an Adjuvant for Combined CD4 and CD8 T Cell Immunity to a Coadministered Protein

The maturation of dendritic cells (DCs) allows these antigen-presenting cells to initiate immunity. We pursued this concept in situ by studying the adjuvant action of -galactosylceramide ( GalCer) in mice. A single i.v. injection of glycolipid induced the full maturation of splenic DCs, beginning within 4 h. Maturation was manifest by marked increases in costimulator and major histocompatibility complex class II expression, interferon (IFN)production, and stimulation of the mixed leukocyte reaction. These changes were not induced directly by GalCer but required natural killer T (NKT) cells acting independently of the MyD88 adaptor protein. To establish that DC maturation was responsible for the adjuvant role of GalCer, mice were given GalCer together with soluble or cell-associated ovalbumin antigen. Th1 type CD4 and CD8 T cell responses developed, and the mice became resistant to challenge with ovalbumin-expressing tumor. DCs from mice given ovalbumin plus adjuvant, but not the non-DCs, stimulated ovalbumin-specific proliferative responses and importantly, induced antigen-specific, IFNproducing, CD4 and CD8 T cells upon transfer into naive animals. In the latter instance, immune priming did not require further exposure to ovalbumin, GalCer, NKT, or NK cells. Therefore a single dose of GalCer i.v. rapidly stimulates the full maturation of DCs in situ, and this accounts for the induction of combined Th1 CD4 and CD8 T cell immunity to a coadministered protein.
A pivoting algorithm for convex hulls and vertex enumeration of arrangements and polyhedra

AbstractWe present a new pivot-based algorithm which can be used with minor modification for the enumeration of the facets of the convex hull of a set of points, or for the enumeration of the vertices of an arrangement or of a convex polyhedron, in arbitrary dimension. The algorithm has the following properties:(a)Virtually no additional storage is required beyond the input data. (b)The output list produced is free of duplicates. (c)The algorithm is extremely simple, requires no data structures, and handles all degenerate cases. (d)The running time is output sensitive for nondegenerate inputs. (e)The algorithm is easy to parallelize efficiently. For example, the algorithm finds thev vertices of a polyhedron inRd defined by a nondegenerate system ofn inequalities (or, dually, thev facets of the convex hull ofn points inRd, where each facet contains exactlyd given points) in timeO(ndv) andO(nd) space. Thev vertices in a simple arrangement ofn hyperplanes inRd can be found inO(n2dv) time andO(nd) space complexity. The algorithm is based on inverting finite pivot algorithms for linear programming.
Symmetry Breaking Through Bell-Jackiw Anomalies

In models of fermions coupled to gauge fields certain current-conservation laws are violated by Bell-Jackiw anomalies. In perturbation theory the total charge corresponding to such currents seems to be still conserved, but here it is shown that nonperturbative effects can give rise to interactions that violate the charge conservation. One consequence is baryon and lepton number nonconservation in V-A gauge theories with charm. Another is the nonvanishing mass squared of the eta .
On the properties of surface reconstructed silicon nanowires

We study by means of density-functional calculations the role of lateral surface reconstructions in determining the electrical properties of silicon nanowires. The different lateral reconstructions are explored by relaxing all the nanowires with crystalline bulk silicon structure and all possible ideal facets that correspond to an average diameter of 1.5 nm. We show that the reconstruction induces the formation of ubiquitous surface states that make the wires semi-metallic or metallic.
Seeing properties of an invisible object: Feature inheritance and shine-through

We characterize a class of spatio-temporal illusions with two complementary properties. Firstly, if a vernier stimulus is flashed for a short time on a monitor and is followed immediately by a grating, the latter can express features of the vernier, such as its offset, its orientation, or its motion (feature inheritance). Yet the vernier stimulus itself remains perceptually invisible. Secondly, the vernier can be rendered visible by presenting gratings with a larger number of elements (shine-through). Under these conditions, subjects perceive two independent “objects” each carrying their own features. Transition between these two domains can be effected by subtle changes in the spatio-temporal layout of the grating. This should allow psychophysicists and electrophysiologists to investigate feature binding in a precise and quantitative manner.
An idiom-finding tool for increasing productivity of accelerators

Suppose one is considering purchase of a computer equipped with accelerators. Or suppose one has access to such a computer and is considering porting code to take advantage of the accelerators. Is there a reason to suppose the purchase cost or programmer effort will be worth it? It would be nice to able to estimate the expected improvements in advance of paying money or time. We exhibit an analytical framework and tool-set for providing such estimates: the tools first look for user-defined idioms that are patterns of computation and data access identified in advance as possibly being able to benefit from accelerator hardware. A performance model is then applied to estimate how much faster these idioms would be if they were ported and run on the accelerators, and a recommendation is made as to whether or not each idiom is worth the porting effort to put them on the accelerator and an estimate is provided of what the overall application speedup would be if this were done. As a proof-of-concept we focus our investigations on Gather/Scatter (G/S) operations and means to accelerate these available on the Convey HC-1 which has a special-purpose "personality" for accelerating G/S. We test the methodology on two large-scale HPC applications. The idiom recognizer tool saves weeks of programmer effort compared to having the programmer examine the code visually looking for idioms; performance models save yet more time by rank-ordering the best candidates for porting; and the performance models are accurate, predicting G/S runtime speedup resulting from porting to within 10% of speedup actually achieved. The G/S hardware on the Convey sped up these operations 20x, and the overall impact on total application runtime was to improve it by as much as 21%.