Miracle-dz/UniFAR-FTUs huggingface dataset:
Relevance and feasibility of a systematic screening of multimorbidities in patients with chronic inﬂammatory rheumatic diseases

Objectives: EULAR recently proposed to screen multimorbidities in chronic inﬂammatory rheumatic dis- eases. The aims of the study were to deﬁne the most common multimorbidities in chronic inﬂammatory rheumatic diseases, compare the screening approach performed in the clinic with the recent EULAR rec- ommendations,validatethepointstoconsiderforthesystematicstandardizedmultimorbidityscreening proposed by EULAR and assess feasibility of such a screening in a daily clinic. Methods: Datawerecollectedprospectivelyduringa1-daymultimorbidityclinic.Diabetes,hypertension, CVD damage, chronic respiratory diseases, osteoporosis and preventive measures were assessed. The comparison with EULAR points to consider was performed retrospectively. Results: We included 200 consecutive patients (157 with rheumatoid arthritis, 37 spondyloarthritis, and 6 connective tissue diseases or vasculitis). The most common multimorbidities already diagnosed in our patients were hypertension (26%) and diabetes (7.5%). Screening showed that 61.5% (CI95%: 54.6%- 67.9%)patientspresentedatleastoneundiagnosedoruncontrolleddiseases:diabetes(6%),hypertension (20.6%), dyslipidemia (16.1%) valvulopathies (16.8%), peripheral artery disease (4.5%); carotid stenosis (6.5%) and aortic aneurysm (5.5%). Overall, 39.9% patients had incomplete cancer screening and 52.8% incompletevaccineschedule.Undiagnosedpulmonaryobstructionandriskofsleepapneaweresuspected in 15.5% and 40.1% patients, respectively. Conclusion: This study underlines the relevance of a systematic screening of multimorbidities in chronic inﬂammatory rheumatic diseases and its feasibility in a 1-day clinic. Spirometry and sleep apnea screening should be added to EULAR points to consider. The long-term impact of such screening needs to be evaluated. undiagnosed or hypertension, dyslipidaemia, abdominal aorta aneurysm, carotid stenosis, cardiopathy, osteoporosis or
Gulf of Mexico Deep Seismic Imaging And Mesozoic Interpretation Initiative

Does enough Mesozoic section underlie the Southeast Louisiana continental shelf and slope to account for the robust petroleum systems there? It is difficult to tell from existing seismic data, but new post-processing techniques are beginning to provide insights into the structure, stratigraphy and geological evolution of the deep basin, perhaps most importantly suggesting the locations of failed Jurassic and Early Cretaceous shelf margins.
The Quality and Readability of Online Consumer Information about Gynaecological Cancer

Objective: The Internet has become an important source of health-related information for consumers, among whom younger women constitute a notable group. The aims of this study were: (1) to evaluate the quality and readability of online information about gynaecological cancer using validated instruments; and (2) to relate the quality of information to its readability. Methods : Using the Alexa Rank we obtained a list of 35 webpages providing information about 7 gynaecological malignancies. These were assessed using the HON seal of approval, the JAMA benchmarks, and the DISCERN instrument. Flesch readability score was calculated for sections related to symptoms and signs, and treatment. Results: Less than 30% of the webpages displayed the HON seal or achieved all JAMA benchmarks. The majority of the treatment sections were of moderate to high quality according to the DISCERN. There was no significant relationship between the presence of the HON seal and readability. Webpages achieving all JAMA benchmarks were significantly more difficult to read and understand than webpages that missed any of the JAMA benchmarks. Treatment-related content of moderate to high quality as assessed by the DISCERN had a significantly better readability score than the low quality content. Conclusions: The online information about gynaecological cancer provided by the most frequently visited webpages is of variable quality and in general difficult to read and understand. The relationship between the quality and readability remains unclear. Healthcare providers should direct their patients to reliable material online since patients consider the Internet as an important source of information.
No effect of classroom sharing on educational achievement in twins: a prospective, longitudinal cohort study

Background: A returning dilemma for families with multiple births is whether twins should share the same, or a parallel classroom, or in other words, whether they should be separated at school or not. This study investigated the effects of sharing a classroom during primary school on cognitive achievement in twins. Method: Subjects were 839 monozygotic and 1164 dizygotic twin pairs who were registered at birth at The Netherlands Twin Register. A prospective, longitudinal study design was used with educational achievement at age 12 years, measured with a standardised test (CITO test), as outcome measure. Results: Most twin pairs (72%) shared a classroom during their schooling, 19% were in separate, but parallel, classes, and 9% “partly” shared a classroom. Twins who were in parallel classrooms had higher CITO scores (mean 539.51; SD 8.12), compared to twins who shared a classroom (537.99; SD 8.52). When controlling for socioeconomic status, and externalising problems before starting primary school (age 3), there was no significant difference in educational achievement between separated and non-separated twin pairs (p = 0.138). In addition, there was no interaction with sex or zygosity of the twins (p = 0.798). Conclusion: There is no difference in educational achievement between twins who share a classroom and twins who do not share a classroom during their primary school time. The choice of separation should be made by teachers, parents and their twin children, based on individual characteristics of a twin pair.
A Reconfigurable Tri-Mode Frequency-Locked Loop Readout Circuit for Biosensor Interfaces

In this article, a frequency-locked loop (FLL) based multimodal readout integrated circuit (IC) for interfacing with off-chip temperature, electrochemical, and pH sensors is presented. By reconfiguring its switched-capacitor feedback network, the readout circuit is able to measure resistance, current, and voltage without additional active analog front-end circuits. A prototype IC was fabricated in a 0.18 μm CMOS process. Measured results show that when measuring resistance, the input-referred resistance resolution is 10.5<inline-formula><tex-math notation="LaTeX">$\Omega$</tex-math></inline-formula> for 100 Hz integration bandwidth. Using an off-chip thermistor, the readout circuit covers a temperature range of 0–75 <inline-formula><tex-math notation="LaTeX">$^{\circ }$</tex-math></inline-formula>C and achieves an equivalent temperature resolution of 16.4 mK<sub>rms</sub>. In current mode, the readout circuit has an input range of 0. 5μA and an input-referred current noise as low as 40.6 pA<sub>rms</sub> for 100 Hz bandwidth. Interfacing with an on-chip potentiostat, glucose chronoamperometry is demonstrated. In voltage mode, a minimum input-referred voltage noise of 31.7 μV<sub>rms</sub> is achieved, and the IC can measure a pH range from 1.6 to 12 using a commercial pH probe. At a 1.2 V supply, power consumption of the readout circuit is below 10 μW for all three measurement modes. Additionally, the prototype IC includes an integrated wireless transmitter that implements on-off keying modulation, and a wireless multimodal sensing system utilizing the FLL-based readout circuit is demonstrated.
Enzymatically Inactive Procaspase 1 stabilizes the ASC Pyroptosome and Supports Pyroptosome Spreading during Cell Division*

Caspase-1 is a key player during the initiation of pro-inflammatory innate immune responses, activating pro-IL-1β in so-called inflammasomes. A subset of patients with recurrent febrile episodes and systemic inflammation of unknown origin harbor mutations in CASP1 encoding caspase-1. CASP1 variants result in reduced enzymatic activity of caspase-1 and impaired IL-1β secretion. The apparent paradox of reduced IL-1β secretion but systemic inflammation led to the hypothesis that CASP1 mutations may result in variable protein interaction clusters, thus activating alternative signaling pathways. To test this hypothesis, we established and characterized an in vitro system of transduced immortalized murine macrophages expressing either WT or enzymatically inactive (p.C284A) procaspase-1 fusion reporter proteins. Macrophages with variant p.C284A caspase-1 did not secrete IL-1β and exhibited reduced inflammatory cell death, referred to as pyroptosis. Caspase-1 and apoptosis-associated speck-like protein containing a CARD (ASC) formed cytosolic macromolecular complexes (so-called pyroptosomes) that were significantly increased in number and size in cells carrying the p.C284A caspase-1 variant compared with WT caspase-1. Furthermore, enzymatically inactive caspase-1 interacted with ASC longer and with increased intensity compared with WT caspase-1. Applying live cell imaging, we documented for the first time that pyroptosomes containing enzymatically inactive variant p.C284A caspase-1 spread during cell division. In conclusion, variant p.C284A caspase-1 stabilizes pyroptosome formation, potentially enhancing inflammation by two IL-1β-independent mechanisms: pyroptosomes convey an enhanced inflammatory stimulus through the recruitment of additional proteins (such as RIP2, receptor interacting protein kinase 2), which is further amplified through pyroptosome and cell division.
COMMENT ON D. E. PARKER, 'EFFECTS OF CHANGING EXPOSURE OF THERMOMETERS AT LAND STATIONS'

This short note reviews the Minutes of two Intercolonial Meteorological Conferences, held at Melbourne, Australia in 1881 and 1888, where the transcripts refer to the use of the Stevenson screen. Additional historical and modern material is reviewed demonstrating the use of the Stevenson screen in late nineteenth century Australia and Fiji. Some possible implications for the climate change debate in Australia are considered.
Confronting Sea With Real Planning: The Case Of Follow-Up In Regional Plans And Programmes In Sweden

This paper addresses the problem of "fit" between strategic environmental assessment (SEA) aims and procedures, and the planning context in which SEA is implemented. The paper approaches this problem from a bottom-up perspective, examining existing planning practices, routines and institutions in order to illuminate prospects and barriers for effective SEA implementation. Using empirical results from studies of regional growth programmes and infrastructure plans in Sweden, the study focuses on SEA follow-up and how it can be integrated in existing planning and programming processes. Environmental follow-up is found to be largely absent from existing planning processes. Analytical, organisational and institutional issues are identified as important explanations for the lack of follow-up. Based on this analysis, the paper offers suggestions on how SEA follow-up can become a more effective part of regional planning.
Enhancement in liver SREBP-1c/PPAR- (cid:11) ratio and steatosis in obese patients: correlations with insulin resistance and long-chain polyunsaturated fatty acid depletion

Sterol receptor element binding protein-1c (SREBP-1c) and peroxisome proliferator activated receptor- a (PPAR- a ) mRNA expression was assessed in liver as signaling mechanisms associated with steatosis in obese patients. Liver SREBP-1c and PPAR- a mRNA (RT-PCR), fatty acid synthase (FAS) and carnitine palmitoyltransferase-1a (CPT-1a) mRNA (real-time RT-PCR), and n-3 long-chain polyunsaturated fatty acid (LCPUFA)(GLC) contents, plasma adiponectin levels (RIA), and insulin resistance (IR) evolution (HOMA) were evaluated in 11 obese patients who underwent subtotal gastrectomy with gastro-jejunal anastomosis in Roux-en-Y and 8 non-obese subjects who underwent laparoscopic cholecystectomy (controls). Liver SREBP-1c and FAS mRNA levels were 33% and 70% higher than control values (P<0.05), respectively, whereas those of PPAR- a and CPT-1a were 16% and 65% lower (P<0.05), respectively, with a significant 62% enhancement in the SREBP-1c/PPAR- a ratio. Liver n-3 LCPUFA levels were 53% lower in obese patients who also showed IR and hipoadiponectinemia over controls (P<0.05). IR negatively correlated with both the hepatic content of n-3 LCPUFA (r=-0.55; P<0.01) and the plasma levels of adiponectin (r=-0.62; P<0.005). Liver SREBP-1c/PPAR- a ratio and n-3 LCPUFA showed a negative correlation (r=-0.48; P<0.02) and positive associations with either HOMA (r=0.75; P<0.0001) or serum insulin levels (r=0.69; the DNA fragments of genes to the respective transcript of expressed
THRESHOLD WIND VELOCITIES OF WET SOILS AS AFFECTED BY WIND BLOWN SAND

Soil moisture influences the susceptibility of a soil to wind erosion and has direct influence on the wind velocity required for initiation of soil movement (threshold wind velocity). Soil texture is another factor affecting threshold wind velocity. Threshold water content (TWC) and threshold friction velocity (U*t) of five soils, ranging from loamy fine sand to clay, under abrading and non-abrading conditions were measured using a suction-type wind tunnel. Each soil was wetted and subjected to 8.5, 10.5, and 13 m s−1 free stream wind velocities at 80 mm above the wind tunnel surface, with and without abrading material in the wind tunnel. Soils with higher clay content had higher water holding capacity at - 1.5 MPa (W‘). Higher TWC for the same wind velocity was obtained for soils with higher W’ or clay content under abrading and nonabrading conditions. All five soils required a similar wind velocity (U*t of 0.31 ms−1 for nonabrading and 0.21 ms−1 for abrading conditions) to initiate their movement at oven dried condition. However, the threshold friction velocity of soils increased about 20% for 0.1 unit of equivalent threshold moisture (TWC/W‘) increment. Because of the erosive impact of abrading materials on soil surface, less wind (U*t) was required to initiate soil erosion with abrasion compared with nonabrading conditions. A soil with a threshold water content of 4% at the surface and 5% at - 1.5 MPa requires U*t of 0.646 ms−1 under nonabrading and 0.596 ms−1 under abrading conditions to start eroding. Wet, loose erodible materials at the soil surface eroded when abrading materials were introduced in the wind tunnel. Predictive equations were developed from which TWC and U*t could be predicted, based on soil physical properties.
The genomic and bioclimatic characterization of Ethiopian barley (Hordeum vulgare L.) unveils challenges and opportunities to adapt to a changing climate

The climate crisis is impacting agroecosystems of the global South, threatening the food security of millions of smallholder farmers. Understanding the effect of current and future climates on crop agrobiodiversity may guide breeding efforts and adaptation strategies to sustain the livelihoods of farmers cropping in challenging conditions. Here, we combine a genomic and climatic characterization of a large collection of traditional barley varieties from Ethiopia, key to food security in local smallholder farming systems. We employ data-driven approaches to characterize their local adaptation to current and future climates and identify barley genomic regions with potential for breeding for local adaptation. We used a sequencing approach to genotype at high- density 436 barley varieties, finding that their genetic diversity can be traced back to geography and environmental diversity in Ethiopia. We integrate this information in a genome-wide association study targeting phenology traits measured in common garden experiments as well as climatic features at sampling points of traditional varieties, describing 106 genomic loci associated with local adaptation. We then employ a machine learning approach to link barley genomic diversity with climate variation, estimating barley genomic offset in future climate scenarios. Our data show that the genomic characterization of traditional agrobiodiversity coupled with climate modelling may contribute to the mitigation of the climate crisis effects on smallholder farming systems.
Deformation‐driven, regional‐scale metasomatism in the Hamersley Basin, Western Australia

Mafic volcanic rocks of the Fortescue Group form the lowermost stratigraphic unit of the 100,000 km2 Hamersley Basin on the southern margin of the Archean Pilbara Craton, Western Australia. A regional burial metamorphic gradient extends across the basin from prehnite–pumpellyite facies in the north to greenschist facies in the south. Phase equilibria modelling of mafic rocks with the computer program thermocalc, in subsets of the system Na2O–CaO–K2O–FeO–MgO–Al2O3–SiO2–H2O–Fe2O3, successfully reproduces observed metamorphic mineral assemblages, giving conditions of ~210 °C, 2 kbar in the north and 335 °C, 3.2 kbar in the south. Superimposed on this metamorphic gradient, regional‐scale metasomatism in the Fortescue Group progressively produces a suite of prehnite‐bearing and pumpellyite–quartz/epidote–quartz‐dominated assemblages. Further modelling of variably metasomatized samples consistently estimates conditions of 260–280 °C, 2.5–3 kbar across the basin. All modelled samples were likely metasomatized at approximately the same structural level, following regional deformation during the Ophthalmian orogeny. Folding during the Ophthalmian orogeny produced topographic and/or tectonic driving forces for regional‐scale fluid flow, pushing metasomatic fluid northwards across the Hamersley Basin. These new phase equilibria calculations support previous interpretations linking the Ophthalmian orogeny, fluid flow and upgrading of Hamersley iron ore deposits. We propose an extension of this fluid flow to the Fortescue Group, the metasomatism of which may have contributed a source of Fe to the Hamersley iron ore deposits.
Regulation by a TGF β -ROCK-actomyosin axis secures a non-linear lumen expansion that is essential for tubulogenesis

Regulationoflumengrowthiscrucial toensure the correct morphology, dimensions and function of a tubular structure. How this is controlled is still poorly understood. During Ciona intestinalis notochord tubulogenesis, single extracellular lumen pockets grow between pairs of cells and eventually fuse into a continuous tube. Here, we show that lumen growth exhibits a lag phase, during which the luminal membranes continue to grow but the expansion of the apical/lateral junction pauses for ∼ 30 min. Inhibition of non-muscle myosin II activity abolishes this lag phase and accelerates expansion of the junction, resultingin the formationofnarrowerlumen pockets partiallyfusinginto a tube of reduced size. Disruption of actin dynamics, conversely, causes a reversal of apical/lateral junction expansion, leading to a dramatic conversion of extracellular lumen pockets to intracellular vacuoles and a tubulogenesis arrest. The onset of the lag phase is correlated with a de novo accumulation of actin that forms a contractile ring at the apical/lateral junctions. This actin ring actively restricts the opening of the lumen in the transverse plane, allowing sufficient time for lumen growth via an osmotic process along the longitudinal dimension. The dynamics of lumen formation is controlled by the TGF β pathway and ROCK activity. Our findings reveal a TGF β -ROCK-actomyosin contractility axis that coordinates lumen growth, which is powered by the dynamics of luminal osmolarity. The regulatory system may function like a sensor/checkpoint that responds to the change of luminal pressure and fine-tunes actomyosin contractility to effect proper tubulogenesis.
The Light-harvesting Chlorophyll a/b-Protein Complex of Chiamydomonas reinhardii1

The molecular organization of chlorophyll in Chlamydomonas reinhardii has been shown to be essentially similar to that in higher plants. Some 50% of the chlorophyll in Chlamydomonas reinhardii chloroplast membranes has been shown to be located in a chlorophyll a/b-protein complex. The complex was isolated in a homogeneous form by hydroxylapatite chromatography of sodium dodecyl sulfate extracts of the chloroplast membranes. Its absorption spectrum exhibits two maxima in the red region at 670 and 652 nm due to the presence of equimolar quantities of chlorophylls a and b in the complex. Preparations of the chlorophyll- protein also contain some of each of the carotenoids observed in the intact chloroplast membrane, but not in the same proportions. The native complex (S value = 2.3S) exhibits a molecular weight of 28,000 + 2,000 on calibrated sodium dodecyl sulfate-polyacrylamide gel electrophoresis. However, on the basis ofits amino acid composition and other data a more probable molecular weight of about 35,000 was calculated. Each 35,000 dalton unit contains three chlorophyll a and three chlorophyll b molecules, and on the average one carotenoid molecule conjugated with proba- bly a single polypeptide of 29,000 daltons. Comparison of spectral and biochemical characteristics demonstrates that this algal chlorophyll-pro- tein is homologous to the previously described major light-harvesting chlorophyll a/b-protein of higher plants. It is anticipated that the Chiamy- domonas complex functions solely in a light-harvesting capacity in analogy to the function determined for the higher plant component.
The Horseshoe Vortex System Around a Circular Bridge Pier on Equilibrium Scoured Bed

Large eddy simulation (LES) is used to investigate the horseshoe vortex (HV) system around a circular bridge pier located on scoured bed corresponding to equilibrium conditions. The deformed bed bathymetry is obtained from experiments. Simulation is performed for two different inflow boundary conditions, one in which the upstream flow is fully turbulent including the turbulent fluctuations obtained from a precalculated LES simulation in a periodic channel (Re=18,000) and one in which the mean streamwise velocity profile corresponding to the first simulation is used (Re=5000, no turbulent fluctuations). The former case corresponds exactly to the experimental conditions, the latter serves to highlight the effect of incoming turbulence on the HV system. The dynamics of the instantaneous coherent structures associated with the HV system around the cylinder and the spectral content of the flow in this region are analyzed. Special attention is given to the interaction between the legs of the horseshoe vortices and the flow behind the cylinder and to the distribution of the bed shear stress. The statistics of the flow are calculated. It is found that the bed shear stress fluctuations around the local mean values can be very high, especially in the scour and near wake regions. The mean flow fields show that for the given scour bathymetry and flow conditions, the mean HV system contains one primary eddy situated fairly close to the cylinder. Inside this eddy the mean pressure fluctuations and resolved kinetic energy levels are very high. Maximum mean bed shear stress levels are observed beneath this eddy as well as close to the small corner vortex at the base of the cylinder.