Miracle-dz/UniFAR-FTUs huggingface dataset:
Institutional Entrepreneurship as Embedded Agency: An Introduction to the Special Issue

We are delighted to introduce this special issue of Organization Studies ,t he purpose of which is to develop a deeper understanding of the concept of institutional entrepreneurship and to offer new avenues for future research. This concept has been attracting considerable attention in recent years, as was reflected in the record number of papers that were submitted ‐ the largest number that this journal has received for any of its special issues to date. As a result, the selection process has been stringent and we are very pleased to present the eight articles in this special issue, all of which survived the demanding review process. Each of these articles contributes important insights to our understanding of institutional entrepreneurship and, collectively, they provide an important benchmark for subsequent research on this phenomenon. In different ways, they explore how actors shape emerging institutions and transform existing ones despite the complexities and path dependences that are involved. In doing so, they shed considerable light on how institutional entrepreneurship processes shape ‐ or fail to shape ‐ the world in which we live and work The term institutional entrepreneurship refers to the ‘activities of actors who have an interest in particular institutional arrangements and who leverage resources to create new institutions or to transform existing ones’ (Maguire, Hardy and Lawrence, 2004: 657). The term is most closely associated with DiMaggio (1988: 14), who argued that ‘new institutions arise when organized actors with sufficient resources see in them an opportunity to realize interests that they value highly’. These actors ‐ institutional entrepreneurs ‐ ‘create a whole new system of meaning that ties the functioning of disparate sets of institutions together’ (Garud, Jain and Kumaraswamy, 2002). Institutional entrepreneurship is therefore a concept that reintroduces agency, interests and power into institutional analyses of organizations. It thus offers promise to researchers seeking to bridge what have come to be called the ‘old’ and ‘new’ institutionalisms in organizational analysis (Powell and DiMaggio, 1991; Greenwood and Hinings, 1996). We preface these papers with some of our own observations on institutional entrepreneurship stemming from its paradoxical nature. Research on institutions has tended to emphasize how organizational processes are shaped by institutional forces that reinforce continuity and reward conformity. In contrast, the literature on entrepreneurship tends to emphasize how organizational processes
THE TEXT MARKING PATTERNS OF COLLEGE STUDENTS

The major purpose of this study was to examine the patterns in college students’ text markings. Used texts from three different content areas were borrowed from the campus bookstore. Each text was examined to determine the kinds of information marked as well as the way in which it was marked. Descriptive statistics and analysis of variance was used to determine differences in marking patterns both within the same text‐type and between different text‐types. The results indicated significant differences between text‐types on only two of the 12 variables indicating little differential marking between text‐types. The results of this study also conclude that, on a whole, students seemed to have little idea how to efficiently and effectively mark text
Confidence in Brazilian Unions

Although unions in Brazil are marginally effective in defining the employer-employee relationship, confidence in unions is high and exhibits a positive trend over time. A logistic regression model based on the Latinobarometer data series (1996–2009) empirically verifies that unions’ state embeddedness really does matter in explaining confidence in unions in Brazil (i.e., confidence in government, especially during the Lula presidency, has a significant positive effect). Moreover, people who have a negative perception of their personal economic situations and are less trustful of others are more inclined to have confidence in unions. Não obstante o efeito bem limitado e marginal dos sindicatos na determinação das relações entre o patrão e o empregado, se mantem alto a confiança nos sindiatos e essa confiança mostra uma tendência positiva no decorrer do tempo. Um modelo de regressão logística baseado no série de dados Latinobarómetro (1996–2009) verifica empiricalmente que a integração dos sindicatos no Estado importa para explicar essa confiança neles, dado que a confiança no governo, sobretudo durante a presidência do Lula, tem tido um efeito positivo. Além disso, as pessoas cuja percepção da sua situação econômica pessoal seja negativa e que tenha menos confiança nos outros inclinam mais para confiar nos sindicatos.
An Overview of Recent Advances in Application of Some Inorganic Materials-Biological and Technological Perspectives

Inorganic compounds which include metals, minerals, and organometallic compounds are used as catalysts, pigments, coatings, surfactants, medicines, fuels and more. They often have high melting points and specific high or low electrical conductivity properties, which make them useful for specific purposes. The scope of the review focusses on the application of a few inorganic materials with special emphasis on their biological and biomaterials perspectives.
Issues and characteristics of testing as part of the design process in mechanical engineering

The design process is a fundamental part of a product development project lifecycle. However the design is not yet finished after the final CAD models and engineering drawings have left the CSCW tools. The design process is highly interconnected with subsequent project phases, especially testing. As, e.g. in the automotive industry, testing is one of the major cost drivers in product development, multiple departments across the company have to collaborate to achieve optimal efficiency. One of the most promising ways to reduce cost in testing is the use of the aspiring simulation technology instead of performing all tests physically. Since most of the data and models needed for the simulations are already created during the design process, it is important not to lose this information, but to allow consistent reuse. For this purpose we present the architecture of a Consistent Data Management Layer (CMDL), our approach to a service-oriented and workflow-driven data management solution, which enables to overcome the heterogeneity of tools and data sources even across different project phases and organizational boundaries.
Abrogation of tumorigenicity and metastasis of murine and human tumor cells by transfection with the murine IFN-beta gene: possible role of nitric oxide.

The purpose of this study was to determine whether sustained local production of murine IFN-beta (mIFN-beta) could inhibit the tumorigenicity and metastasis of human and murine tumor cells implanted into nude mice. Human melanoma cells (A375SM), renal carcinoma cells (SN12PM6), and colon carcinoma cells (KM12SM) were transfected with mIFN-beta or a control neomycin resistance vector. All cell lines grew well in culture. Tumor cells were injected into the subcutis, kidney, spleen, or lateral tail vein of nude mice. Parental or control transfected cells produced local tumors and experimental or spontaneous lung metastases, whereas mIFN-beta-transfected cells did not. In vivo survival experiments using [125I]IdUdR-labeled cells showed that by day 7 after s.c. implantation, all IFN-beta-transfected cells died. IFN-beta transfection prevented the outgrowth of parental or control-transfected cells only when they were injected together with transfected cells into one site, suggesting that IFN-beta promoted a local lysis of the bystander cells. Similar indirect antitumor activity was demonstrated in various human (KM12SM and SN12PM6) and murine (CT-26 colon carcinoma, RENCA renal cell carcinoma, and 3LL Lewis lung carcinoma) tumors. The IFN-beta-transfected tumor cells stimulated a high level of nitric oxide production by murine macrophages under in vitro and in vivo conditions, which correlated with the vigorous nonspecific antitumor activity. Collectively, these results demonstrate that local production of IFN-beta can eradicate tumor cells of different histology by inducing inducible nitric oxide synthase expression in infiltrating cells.
Ambroxol Hydrochloride Combined with Fluconazole Reverses the Resistance of Candida albicans to Fluconazole

In this study, we found that ambroxol hydrochloride (128 μg/mL) exhibits synergistic antifungal effects in combination with fluconazole (2 μg/mL) against resistant planktonic Candida albicans (C. albicans) cells. This combination also exhibited synergistic effects against resistant C. albicans biofilms in different stages (4, 8, and 12 h) according to the microdilution method. In vitro data were further confirmed by the success of this combination in treating Galleria mellonella infected by resistant C. albicans. With respect to the synergistic mechanism, our result revealed that ambroxol hydrochloride has an effect on the drug transporters of resistant C. albicans, increasing the uptake and decreasing the efflux of rhodamine 6G, a fluorescent alternate of fluconazole. This is the first study to investigate the in vitro and in vivo antifungal effects, as well as the possible synergistic mechanism of ambroxol hydrochloride in combination with fluconazole against resistant C. albicans. The results show the potential role for this drug combination as a therapeutic alternative to treat resistant C. albicans and provide insights into the development of antifungal targets and new antifungal agents.
Color Image Segmentation using Watershed Algorithm

Image segmentation and its performance evaluation are very difficult but important problems in computer vision. A major challenge in segmentation evaluation comes from the fundamental conflict between generality and objectivity. The goal of image segmentation is to cluster pixels into salient image regions, i.e., regions corresponding to individual surfaces, objects, or natural parts of objects. With the improvement of computer processing capabilities and the increased application of color image, the color image segmentation are more and more concerned by the researchers. Color image segmentation methods can be seen as an extension of the gray image segmentation method in the color images, but many of the original gray image segmentation methods cannot be directly applied to color images. This requires improving the method of original gray image segmentation method according to the color image which have the feature of rich information or research a new image segmentation method it specially used in color image segmentation. This article proposes a color image segmentation method of automatic seed region growing on basis of the region with the combination of the watershed algorithm with seed region growing algorithm which based on the traditional seed region growing algorithm.
Design of high-speed multiplierless filters using a nonrecursive signed common subexpression algorithm

In this work, a new algorithm called nonrecursive signed common subexpression elimination (NR-SCSE) is discussed, and several applications in the area of multiplierless finite-impulse response (FIR) filters are developed. While the recursive utilization of a common subexpression generates a high logic depth into the digital structure, the NR-SCSE algorithm allows the designer to overcome this problem by using each subexpression once. The paper presents a complete description of the algorithm, and a comparison with two other well-known options: the graph synthesis, and the classical common subexpression elimination technique. Main results show that the NR-SCSE implementations of several benchmark circuits offer the best relation between occupied area and logic depth respect to the previous values published in the technical literature.
Interactions between antidepressants and P‐glycoprotein at the blood–brain barrier: clinical significance of in vitro and in vivo findings

The drug efflux pump P‐glycoprotein (P‐gp) plays an important role in the function of the blood–brain barrier by selectively extruding certain endogenous and exogenous molecules, thus limiting the ability of its substrates to reach the brain. Emerging evidence suggests that P‐gp may restrict the uptake of several antidepressants into the brain, thus contributing to the poor success rate of current antidepressant therapies. Despite some inconsistency in the literature, clinical investigations of potential associations between functional single nucleotide polymorphisms in ABCB1, the gene which encodes P‐gp, and antidepressant response have highlighted a potential link between P‐gp function and treatment‐resistant depression (TRD). Therefore, co‐administration of P‐gp inhibitors with antidepressants to patients who are refractory to antidepressant therapy may represent a novel therapeutic approach in the management of TRD. Furthermore, certain antidepressants inhibit P‐gp in vitro, and it has been hypothesized that inhibition of P‐gp by such antidepressant drugs may play a role in their therapeutic action. The present review summarizes the available in vitro, in vivo and clinical data pertaining to interactions between antidepressant drugs and P‐gp, and discusses the potential relevance of these interactions in the treatment of depression.
Weft, Warp, and Weave: The Intricate Tapestry of Calcium Channels Regulating T Lymphocyte Function

Calcium (Ca2+) is a universal second messenger important for T lymphocyte homeostasis, activation, proliferation, differentiation, and apoptosis. The events surrounding Ca2+ mobilization in lymphocytes are tightly regulated and involve the coordination of diverse ion channels, membrane receptors, and signaling molecules. A mechanism termed store-operated Ca2+ entry (SOCE), causes depletion of endoplasmic reticulum (ER) Ca2+ stores following T cell receptor (TCR) engagement and triggers a sustained influx of extracellular Ca2+ through Ca2+ release-activated Ca2+ (CRAC) channels in the plasma membrane. The ER Ca2+ sensing molecule, stromal interaction molecule 1 (STIM1), and a pore-forming plasma membrane protein, ORAI1, have been identified as important mediators of SOCE. Here, we review the role of several additional families of Ca2+ channels expressed on the plasma membrane of T cells that likely contribute to Ca2+ influx following TCR engagement, particularly highlighting an important role for voltage-dependent Ca2+ channels (CaV) in T lymphocyte biology.
Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges

Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in human neonates, and is often associated with persistent motor, sensory, and cognitive impairment. Improved intensive care technology has increased survival without preventing neurological disorder, increasing morbidity throughout the adult population. Early preventative or neuroprotective interventions have the potential to rescue brain development in neonates, yet only one therapeutic intervention is currently licensed for use in developed countries. Recent investigations of the transient cortical layer known as subplate, especially regarding subplate’s secretory role, opens up a novel set of potential molecular modulators of neonatal HI injury. This review examines the biological mechanisms of human neonatal HI, discusses evidence for the relevance of subplate-secreted molecules to this condition, and evaluates available animal models. Neuroserpin, a neuronally released neuroprotective factor, is discussed as a case study for developing new potential pharmacological interventions for use post-ischaemic injury.
Evolving Work Routines: Adaptive Routinization of Information Technology in Healthcare

Despite the significant potential for performance gains from health IT (HIT), there has been limited study of the mechanisms underlying successful HIT implementations. We conducted an extensive longitudinal field study to gain an understanding of the interplay between technology and patterns of clinical work embodied in routines. We use the analytical device of narrative networks to identify where and how HIT influences patterns of work. We further draw upon adaptive structuration theory to conceptualize HIT as an intervention that alters the flow of events in a narrative network. Our findings suggest that the key to successful implementation is to manage the co-evolution process between routines and HIT and to actively orchestrate a virtuous cycle through agentic action. We propose a dynamic process model of adaptive routinization of HIT that delineates the major channels through which HIT and routines interact, identifies the different stages in the dynamic co-evolution process, and isolates the pivotal role of two forms of agency in enabling the virtuous cycle of co-evolution. This is one of the first studies to offer a processual, microlevel analysis of HIT implementation in a clinical setting.
Partnership between institutions of further and higher education: a grounded theory

Partnership arrangements between institutions of higher education and further education have developed in order that opportunities for access and progression can be provided on both a regional and national basis. Underpinning this is a commitment to provide the general public with a greater choice of vocational educational provision which it is hoped will stimulate individuals to update themselves by undertaking programmes of advanced study. Furthermore, it is anticipated that employers will encourage able employees to upgrade their skill base through organisational sponsorship, the objective being to groom high-fliers for greater responsibility. A franchise operation can be placed within the strategic planning process of each type of partner institution. This is owing to the fact that staff at the partner institutions view franchising as a means of market entry or the development of market share (increased market reach). Bearing this in mind, it is important to suggest that
Observing Leadership Roles in Shared Decision Making: A Preliminary Analysis of Three Teams

Despite recent attention to shared decision making as an approach to school reform, relatively little research has been conducted on the topic, and much of that research has relied on interviews and field notes, rather than systematic observation of team functioning. This investigation integrated systematic observations and interviews. The purpose of this study was to describe the leadership behaviors exhibited by principals, team leaders, and other team members (teachers, parents, students). We defined leadership according to team member contributions to decisions (decision content, decision-making processes, and statement function, such as initiating topics and making suggestions). This investigation used a comparative case study approach to examine the shared decision-making teams from three schools during the teams' first year. Results revealed variability in leadership across the three teams. Two teams were characterized by positive group process procedures with active involvement from a number of team members. A third team was dominated by the building principal with minimal input from most team members. This team appeared to be less productive than the other two. These findings are viewed in relationship to prior research literature concerning the ambiguity of team members' roles, lack of clarity concerning the power of shared decision-making teams, and the impact of school vision. Suggestions are made for future research.
Perinatal Exogenous Nitric Oxide in Fawn-Hooded Hypertensive Rats Reduces Renal Ribosomal Biogenesis in Early Life

Nitric oxide (NO) is known to depress ribosome biogenesis in vitro. In this study we analyzed the influence of exogenous NO on ribosome biogenesis in vivo using a proven antihypertensive model of perinatal NO administration in genetically hypertensive rats. Fawn-hooded hypertensive rat (FHH) dams were supplied with the NO-donor molsidomine in drinking water from 2 weeks before to 4 weeks after birth, and the kidneys were subsequently collected from 2 day, 2 week, and 9 to 10-month-old adult offspring. Although the NO-donor increased maternal NO metabolite excretion, the NO status of juvenile renal (and liver) tissue was unchanged as assayed by EPR spectroscopy of NO trapped with iron-dithiocarbamate complexes. Nevertheless, microarray analysis revealed marked differential up-regulation of renal ribosomal protein genes at 2 days and down-regulation at 2 weeks and in adult males. Such differential regulation of renal ribosomal protein genes was not observed in females. These changes were confirmed in males at 2 weeks by expression analysis of renal ribosomal protein L36a and by polysome profiling, which also revealed a down-regulation of ribosomes in females at that age. However, renal polysome profiles returned to normal in adults after early exposure to molsidomine. No direct effects of molsidomine were observed on cellular proliferation in kidneys at any age, and the changes induced by molsidomine in renal polysome profiles at 2 weeks were absent in the livers of the same rats. Our results suggest that the previously found prolonged antihypertensive effects of perinatal NO administration may be due to epigenetically programmed alterations in renal ribosome biogenesis during a critical fetal period of renal development, and provide a salient example of a drug-induced reduction of ribosome biogenesis that is accompanied by a beneficial long-term health effect in both males and females.
Maternal and Neonatal Outcomes in Korean Women with Type 1 and Type 2 Diabetes

Background The purpose of this study was to evaluate maternal and neonatal outcomes in Korean women with type 1 diabetes and type 2 diabetes. Methods We performed a retrospective survey of 163 pregnancies in women with type 1 diabetes (n=13) and type 2 diabetes (n=150) treated from 2003 to 2010 at Cheil General Hospital & Women's Healthcare Center, Korea. We compared maternal characteristics as well as maternal and neonatal outcomes between groups. Results Differences in glycosylated hemoglobin between type 1 and type 2 diabetes were not significant. Birth weight (3,501±689.6 g vs. 3,366±531.4 g) and rate of major congenital malformations (7.7% vs. 5.6%) were not significantly different. However, women with type 1 diabetes had higher rates of preeclampsia (38.5% vs. 8.2%, P=0.006), large for gestational age (LGA; 46.2% vs. 20.4%, P=0.004), macrosomia (38.5% vs. 13.4%, P=0.032), and admission for neonatal care (41.7% vs. 14.8%, P=0.03) than women with type 2 diabetes. Conclusion Maternal and neonatal outcomes for women with type 1 diabetes were poorer than for women with type 2 diabetes, especially preeclampsia, LGA, macrosomia and admission to the neonatal intensive care unit.
List Decoding for Bidirectional Broadcast Channels with Unknown Varying Channels

The concept of bidirectional relaying shows the potential to improve the performance in wireless networks such as sensor, ad-hoc, and even cellular systems. It applies to three-node networks, where a relay node establishes a bidirectional communication between two other nodes. In the first phase of a decode-and-forward protocol, the two nodes transmit their messages to a relay node, which decodes them. In the succeeding bidirectional broadcast phase, the relay broadcasts a re-encoded composition of them so that both nodes can decode the other's message using their own message as side information. We assume that the transmission is affected by unknown varying channels. Unfortunately, the unknown variation of the channel can lead to channels which completely prohibit any reliable communication. In this work, we analyze the bidirectional broadcast phase under list decoding and show that this decoding technique can improve the performance significantly in the sense that it allows to transmit reliably in scenarios where usual decoding schemes fail.