Miracle-dz/UniFAR-FTUs huggingface dataset:
Lycopene and Soy Isoflavones in the Treatment of Prostate Cancer

Abstract Dietary intake of lycopene and soy has been associated with a lower risk of prostate cancer. In vitro studies with lycopene and genistein, a soy isoflavone, have shown induction of apoptosis and inhibition of cell growth in androgen-sensitive (LNCaP) and androgen–independent (PC3 and VeCaP) prostate cancer cell lines. In a previous Phase II clinical trial in prostate cancer patients, we observed prostate-specific antigen (PSA) stabilization with soy isoflavone intake. In this Phase II clinical trial, we investigated the efficacy of lycopene alone or in combination with soy isoflavones on serum PSA levels in men with prostate cancer. To be eligible for the study, men with prostate cancer had to have rising serum PSA following local therapy or while on hormone therapy. Study population included 71 eligible patients who had 3 successive rising PSA levels or a minimum PSA of 10 ng/ml at 2 successive evaluations prior to starting therapy. Subjects were randomly assigned to receive a tomato extract capsule containing 15 mg of lycopene alone (n = 38) or together with a capsule containing 40 mg of a soy isoflavone mixture (n = 33) twice daily orally for a maximum of 6 mo. One patient on the lycopene arm did not receive therapy due to his inability to ingest the study pill. There was no decline in serum PSA in either group qualifying for a partial or complete response. However, 35 of 37 (95%) evaluable patients in the lycopene group and 22 of 33 (67%) evaluable patients in the lycopene plus soy isoflavone group achieved stable disease described as stabilization in serum PSA level. The data suggest that lycopene and soy isoflavones have activity in prostate cancer patients with PSA relapse disease and may delay progression of both hormone-refractory and hormone-sensitive prostate cancer. However, there may not be an additive effect between the 2 compounds when taken together. Future studies are warranted to further investigate the efficacy of lycopene and soy isoflavones in prostate cancer as well as the mechanism of potential negative interaction between them.
A collaborative Web browsing system for multiple mobile users

In mobile computing environments, handheld devices with low functionality restrict the services provided for mobile users. We propose a new concept of collaborative browsing, where mobile users collaboratively browse Web pages designed for desktop PC. In collaborative browsing, a Web page is divided into multiple components, and each is distributed to a different device. In mobile computing environments, the number of handheld devices, their capabilities, and other conditions can vary widely amongst mobile users who want to browse content. Therefore, we developed a page partitioning method for collaborative browsing, which divides a Web page into multiple components. Moreover, we designed and implemented a collaborative Web browsing system in which users can search and browse their target information by discussing and watching partial pages displayed on multiple devices
Carcinogenicity and Chronic Toxicity in Mice and Rats Administered Vinyl Acetate Monomer in Drinking Water

Carcinogenicity and Chronic Toxicity in Mice and Rats Administered Vinyl Acetate Monomer in Drinking Water: Yumi Umeda, et al. Japan Bioassay Research Center, Japan Industrial Safety and Health Association—Carcinogenicity and chronic toxicity of vinyl acetate monomer (VA) were examined in male and female Crj:BDF1 mice and F344/DuCrj Rats. Groups of 50 mice and 50 rats of each sex were orally administered VA in drinking water containing 0, 400, 2,000 or 10,000 ppm (g/g) VA for 104 wk. Squamous cell tumors were clearly evident in the upper digestive tract of treated mice and rats, and in the larynx of treated mice of both sexes. In mice, squamous cell carcinomas and papillomas were observed in the oral cavity, esophagus, forestomach and larynx of the 10,000 ppm group, together with basal cell hyperplasia, squamous cell hyperplasia and epithelial dysplasia. In rats, incidences of squamous cell carcinomas and papillomas were increased in the oral cavity of the 10,000 ppm group of both sexes, and an esophagus squamous cell carcinoma was observed in a 10,000 ppm female. Pre‐neoplastic hyperplasias were also noted. Mapping of the neoplastic and pre‐neoplastic lesions in the oral cavity of the 10,000 ppm group revealed that both the lesions occurred predominantly at Level V in mice and at Level VI in rats. A lower confidence limit of a benchmark dose (BMDL10) of 477 mg/kg/d was obtained from a dose‐response relationship between combined incidence of squamous cell carcinomas and papillomas in the oral cavity of mice and rats and the estimated daily VA intakes per body weight, and compared with literature values.
The Impact of Digital Education Delivery on Postoperative Pain Outcomes

i Acknowledgements . ii Problem Statement. 1 Background . 1 Pain Management. 1 Patient Education . 3 Novel Approach . 4 Purpose. 6 Purpose Statement . 6 Hypothesis and Study Aims . 6 Review of the Literature . 7 Significance. 11 Theoretical Framework . 12 Adult Learning Theory . 12 Study Variables . 13 Method . 13 Design . 13 Study Population . 13 Sample Size . 14 Recruitment . 14 Intervention . 14 Study group . 16 iv DIGITAL EDUCATION DELIVERY Control group . 17 Management of interventions and study participants . 17 Instruments . 18 Patient demographics and clinical characteristics . 18 Pain outcomes . 19 Pain knowledge . 20 Chart audit . 20 Data Management . 21 Data Collection Procedure . 21 Data Analysis Plan . 21 Ethical Considerations . 22 Results . 23 Patient Characteristics . 23 Education Use, Satisfaction, and Treatment Participation . 24 Pain Knowledge . 24 Pain Outcomes . 25 Discussion. 25 Limitations . 29 Implications and Recommendations . 31 Conclusions . 32 References . 33 Appendix A . 44 Table 1. Study Variables . 44 v DIGITAL EDUCATION DELIVERY Appendix B . 45 Oral Consent Script . 45 Appendix C . 46 HIPAA Authorization to Use and Disclose Protected Health Information . 46 Appendix D . 48 Figure 1. Screen Shot of Digital Pain Education Application . 48 Figure 2. Screen Shot of Digital Pain Education Unit . 49 Figure 3. Screen Shot of Interactive Pain Assessment . 50 Figure 4. Screen Shot of Interactive Digital Pain Management Menu . 51 Appendix E . 52 Figure 5. Your Pain and Discomfort Management Menu. 52 Appendix F . 53 Figure 6. Communicating About Your Pain . 53 Appendix G . 54 Study (Fidelity) Checklist . 54 Appendix H . 56 Patient Demographics and Past Medical History Form . 56 Appendix I . 58 Revised American Pain Society Patient Outcome Questionnaire (APS-POQ-R) . 58 Appendix J . 60 Revised Patient Pain Questionnaire (PPQ) . 60 Appendix K . 61 Chart Audit Form . 61 vi DIGITAL EDUCATION DELIVERY Appendix L . 63 Data Collection Study Protocol . 63 Appendix M . 66 IRB Approval Letter . 66 IRB Closure Letter .
Investigating Student Communities with Network Analysis of Interactions in a Physics Learning Center

We describe our initial efforts at implementing social network analysis to visualize and quantify student interactions in Florida International University’s Physics Learning Center. Developing a sense of community among students is one of the three pillars of an overall reform effort to increase participation in physics, and the sciences more broadly, at FIU. Our implementation of a research and learning community, embedded within a course reform effort, has led to increased recruitment and retention of physics majors. Finn and Rock [1997] link the academic and social integration of students to increased rates of retention. To identify these interactions, we have initiated an investigation that utilizes social network analysis to identify primary community participants. Community interactions are then characterized through the network’s density and connectivity, shedding light on learning communities and participation. Preliminary results, further research questions, and future directions utilizing social.
Proposal of charging system from unstable power supply to the lithium-ion battery

Recently, the Lithium-ion Battery is used as the energy storage device for interconnection distributed system that utilizes solar cell. However, the power obtained by the solar cell becomes unstable by the weather condition. This paper shows the charging system that can be charged efficiently the Lithium-ion Battery from the unstable power source such as solar cell. The charging equipment applies a DC-DC Converter using the SiC-MOSFET to realize high efficiency and low degradation. In addition, this paper shows charging equipment composed by the Master-Slave system. This equipment can realize the low degradation charging and MPPT control of solar power system.
Classification of spectroscopical imagery by combining spectral and spatial information : the SSC Method

Classification of remotely sensed images is often based on assigning classes on a 'per-pixel' basis and therefore ignoring spatial information captured by the image. In this paper a method is proposed that combines spatial and spectral information in two steps. Spatial information is first extracted by segmentation: spectral homogeneous regions in the image are identified on the basis of similarity of the entire spectral shape from visible to shortwave infrared. These homogeneous areas are classified and next, this information is used to classify the remaining heterogeneous pixels. The method is applied and validated on DAIS images acquired over an area covered with natural vegetation and agricultural activities in southern France. Results indicate significant improvements of classification results compared to traditional per-pixel classifiers.
Gene Maps Linearization Using Genomic Rearrangement Distances

A preliminary step to most comparative genomics studies is the annotation of chromosomes as ordered sequences of genes. Different genetic mapping techniques often give rise to different maps with unequal gene content and sets of unordered neighboring genes. Only partial orders can thus be obtained from combining such maps. However, once a total order O is known for a given genome, it can be used as a reference to order genes of a closely related species characterized by a partial order P. Our goal is to find a linearization of P that is as close as possible to O, in term of a given genomic distance. We first prove NP-completeness complexity results considering the breakpoint and the common interval distances. We then focus on the breakpoint distance and give a dynamic programming algorithm whose running time is exponential for general partial orders, but polynomial when the partial order is derived from a bounded number of genetic maps. A time-efficient greedy heuristic is then given for the general case and is empirically shown to produce solutions within 10% of the optimal solution, on simulated data. Applications to the analysis of grass genomes are presented.
Multiple-Radar Data Assimilation and Short-Range Quantitative Precipitation Forecasting of a Squall Line Observed during IHOP_2002

Abstract The impact of multiple–Doppler radar data assimilation on quantitative precipitation forecasting (QPF) is examined in this study. The newly developed Weather Research and Forecasting (WRF) model Advanced Research WRF (ARW) and its three-dimensional variational data assimilation system (WRF 3DVAR) are used. In this study, multiple–Doppler radar data assimilation is applied in WRF 3DVAR cycling mode to initialize a squall-line convective system on 13 June 2002 during the International H2O Project (IHOP_2002) and the ARW QPF skills are evaluated for the case. Numerical experiments demonstrate that WRF 3DVAR can successfully assimilate Doppler radial velocity and reflectivity from multiple radar sites and extract useful information from the radar data to initiate the squall-line convective system. Assimilation of both radial velocity and reflectivity results in sound analyses that show adjustments in both the dynamical and thermodynamical fields that are consistent with the WRF 3DVAR balance constrai.
Mechanical properties and life time of high Pb-containing solder joints

High lead-containing soft solders with melting points of above 300°C are still widely used in power semiconductors for high temperature applications due to lack of reliable and cost effective lead-free alternative solutions. In this study the influence of aging on stress-strain response and fatigue life of solder joints prepared with two types of high-Pb solder alloys with different Sn content was investigated. Tensile experiments were carried out by using model solder joints prepared with Cu or Ni strips as substrates. Multi-layered samples consisting of Ni-coated Si chips soldered on metallized ceramic substrates were used for isothermal bending fatigue studies. The growth rate of the Cu-Sn interfacial intermetallic compound (IMC) was found to be considerably higher than that of Ni-Sn IMC. Independent from the substrate material a higher IMC growth rate was always observed in the solder joints prepared with a higher Sn content. On the other hand, these joints showed a clear improvement of tensile and fatigue properties. The moderate fatigue response of the PbSnAg solder joints with a lower Sn content could be related to the occurrence of interfacial delamination. Furthermore, it was found that not only the Sn concentration of the solder but also the thickness of the wettable substrate affects the spalling and delamination of the interfacial IMC layer. Finally, it is demonstrated that accelerated isothermal bending fatigue testing can be used for rapid evaluation of large area solder joints in electronics.
Text mining with conceptual graphs

A method for conceptual clustering of a collection of texts represented with conceptual graphs is presented. It uses an incremental strategy to construct the cluster hierarchy and incorporates some characteristics attractive for text mining purposes. For instance, it considers the structural information of the graphs, uses domain knowledge to detect the clusters with generalized descriptions, and uses a user-defined similarity measure between the graphs.
Atomistic Origins of High-Performance in Hybrid Halide Perovskite Solar Cells

The performance of organometallic perovskite solar cells has rapidly surpassed that of both conventional dye-sensitized and organic photovoltaics. High-power conversion efficiency can be realized in both mesoporous and thin-film device architectures. We address the origin of this success in the context of the materials chemistry and physics of the bulk perovskite as described by electronic structure calculations. In addition to the basic optoelectronic properties essential for an efficient photovoltaic device (spectrally suitable band gap, high optical absorption, low carrier effective masses), the materials are structurally and compositionally flexible. As we show, hybrid perovskites exhibit spontaneous electric polarization; we also suggest ways in which this can be tuned through judicious choice of the organic cation. The presence of ferroelectric domains will result in internal junctions that may aid separation of photoexcited electron and hole pairs, and reduction of recombination through segregation of charge carriers. The combination of high dielectric constant and low effective mass promotes both Wannier-Mott exciton separation and effective ionization of donor and acceptor defects. The photoferroic effect could be exploited in nanostructured films to generate a higher open circuit voltage and may contribute to the current–voltage hysteresis observed in perovskite solar cells.
The uniqueness of amerindians according to HLA genes and the peopling of the Americas

The genetic profiles of human populations are being used for epidemiology and preventive/predictive medicine, in addition to ascertaining the origin and relatedness of ethnic groups for anthropological studies. HLA is the most polymorphic genetic system in humans and a few HLA alleles are linked to disease. However, the mtDNA and Chr Y variants, widely used in genetic anthropology, are linked to disease to a much higher degree than HLA, if we only take into account the number of «healthy» alleles from these three different genetic markers. HLA gene studies allow the determination of the origin and genetic relatedness of worldwide populations. In the present study we have been able to uncover that Amerindians apparently do not relate with any other worldwide population, according to their HLA genetic profile. Amerindians are the very First American Natives that were already in America when Na Dene (Athabascans, Navajo, Apache) and Eskimo speaking people reached it. While other worldwide populations are genetically related following generally a smooth geographic gradient, Amerindians appear apart. This main conclusion has been reached by using 14,968 worldwide HLA chromosomes and Neighbour Joining and corres
Microcalorimetric Investigation on Aggregation and Dissolution of Poly(N-isopropylacrylamide) Chains in Water

Aggregation and dissolution of poly(N-isopropylacrylamide) (PNIPAM) in water were investigated using an ultrasensitive differential scanning calorimetry (US-DSC) and a pressure perturbation calorimetry (PPC). US-DSC reveals that both the aggregation and dissolution of PNIPAM chains are greatly dependent on the scanning rate, indicating that the processes are kinetically controlled. The hysteresis in the dissolution process was found to have a nonequilibrium nature, which is thought to be related to the additional hydrogen bondings formed in the collapsed state of PNIPAM chains. A bimodal appearing in the cooling process at a slow scanning rate indicates the dissolution involves two different processes, i.e., the disruption of additional hydrogen bondings and the dissolution of the collapsed chains. PPC reveals that the solvent accessible surface area of PNIPAM chains in the cooling process is smaller than that in the heating process, which further indicates the dissolution of the PNIPAM aggregates involve.
Introducing compassion-focused therapy

Shame and self-criticism are transdiagnostic problems. People who experience them may struggle to feel relieved, reassured or safe. Research suggests that a specialised affect regulation system (or systems) underpins feelings of reassurance, safeness and well-being. It is believed to have evolved with attachment systems and, in particular, the ability to register and respond with calming and a sense of well-being to being cared for. In compassion-focused therapy it is hypothesised that this affect regulation system is poorly accessible in people with high shame and self-criticism, in whom the ‘threat’ affect regulation system dominates orientation to their inner and outer worlds. Compassion-focused therapy is an integrated and multimodal approach that draws from evolutionary, social, developmental and Buddhist psychology, and neuroscience. One of its key concerns is to use compassionate mind training to help people develop and work with experiences of inner warmth, safeness and soothing, via compassion and self-compassion.
Conventional and electronic cigarettes (e-cigarettes) have different smoking characteristics.

INTRODUCTION Electronic cigarettes or e-cigarettes are marketed as tobacco-free nicotine delivery devices that have received little laboratory evaluation. In this study, the smoking properties of conventional and e-cigarettes were compared by examining the vacuum required to produce smoke (conventional cigarettes) or aerosol (e-cigarettes) and the density of the smoke/aerosol over time. METHODS Vacuum was measured using a manometer coupled to a smoking machine. The density of aerosol or smoke was measured spectrophotometrically. E-cigarettes were subjected to smoke-out experiments in which vacuum and aerosol density were measured until each cartridge was exhausted. RESULTS The vacuum required to smoke conventional cigarettes varied among the eight brands tested. Lights and ultra-light brands required stronger vacuums to smoke than unfiltered and regular filtered brands. Except for one brand, higher vacuums were required to smoke e-cigarettes than conventional brands. Smoke/aerosol density was stable for conventional brands and for e-cigarettes over the first 10 puffs; however, aerosol density of e-cigarettes dropped during subsequent smoking, and higher vacuums were required to produce aerosol as the puff number increased. While conventional cigarettes were uniform in their smoking behavior within brands, vacuum and density varied within brands of e-cigarettes. DISCUSSION Generally, e-cigarettes required stronger vacuums (suction) to smoke than conventional brands, and the effects of this on human health could be adverse. The amount of aerosol produced by e-cigarettes decreased during smoking, which necessitated increasing puff strength to produce aerosol. The decreased efficiency of aerosol production during e-cigarette smoking makes dosing nonuniform over time and calls into question their usefulness as nicotine delivery devices.
Clustering of Non-Alignable Protein Sequences

We are interested in the problem of grouping families of nonalignable protein sequences, such as circular-permutation, multidomain and tandem-repeat proteins, into clusters (classes) of related biological functions. For such sequences, whose numbers are constantly growing, the commonly used alignment-dependent approaches fail to yield biologically plausible results. To the best of our knowledge, no automatic process yet exists to carry out clustering on these proteins. Biologists often use more complex manual approaches based on secondary and tertiary structures, which require considerably more resources and time. In this paper, we develop a new similarity measure SMS, applied directly on non-aligned sequences. It allows us to develop a new and original alignment-free algorithm, named CLUSS, for clustering protein families based on a spectral decomposition approach inspired by the latent semantic analysis (LSA) widely used in information retrieval. CLUSS, utilized jointly with SMS, is effective on both alignable and non-alignable protein sequences. To show this, we have extensively tested our algorithm on different benchmark protein databases and families; we have also compared its performance with many alignment-dependent mainstream algorithms. The source code, the application server, and all experimental results are available at CLUSS web site http://prospectus.usherbrooke. ca/CLUSS/.
On the effects of traceability links in differently sized software systems

Context: None of the published empirical studies on software traceability have comparatively examined the support for differently sized systems. Objective: This paper reports on two controlled experiments performed with two Enterprise Service Bus (ESB) systems that are comparable in terms of support features and system structure, but are different in their size, in particular, UltraESB Version 2.3. 0 and PetalsESB Version 4.2. 0, to investigate the effects of system size on the use of traceability links. Method: We conducted two controlled experiments in which the same impact evaluation activities were performed and measured how the control groups (provided with no traceability information) and the experiment groups (provided with traceability information) performed these activities in terms of the quantity and quality of retrieved elements. Results: Our findings show that the 133.71% larger size of one of ESBs does not have a significant influence on the quantity and quality of retrieved elements in the experiment groups. In the control groups, in contrast, this increase in system size significantly increases the quantity of incorrect elements and reduces the overall quality of elements retrieved, while no conclusive evidence concerning the quantity of missing elements was found. Conclusion: It is concluded that traceability is more important in larger software systems.