Miracle-dz/UniFAR-FTUs huggingface dataset:
Chronic work stress and marital dissolution increase risk of posttrial mortality in men from the Multiple Risk Factor Intervention Trial.

BACKGROUND Acute life stressors can trigger premature death, but the role of more enduring, chronic stressors is less clear. We evaluated men's mortality risk associated with number of different work stressors and marital dissolution during the Multiple Risk Factor Intervention Trial (MRFIT). METHODS Men without definite evidence of coronary heart disease (CHD) at study entry but with above-average risk for CHD mortality based on blood pressure, serum cholesterol levels, and/or cigarette smoking were recruited into MRFIT. Survivors at the end of the trial were followed up for mortality for an additional 9 years. All 12,336 survivors who completed the work-event checklist at the annual evaluations during the trial were included in the analyses of work stressors, whereas the 10,904 who were married at the start of the trial were included in the analyses of marital dissolution. RESULTS Increasing number of different work stressors and divorce during the trial were associated with total and cardiovascular mortality during the 9-year follow-up period (Ps<.01 for linear trend), with a relative risk of 1.26 (95% confidence interval, 1.07-1.48) for those reporting 3 or more different work stressors compared with those reporting none, and relative risk of 1.37 (95% confidence interval, 1.09-1.72) for those who divorced compared with those who remained married for total mortality. Analyses were adjusted for age, intervention group, educational attainment, occurrence of a nonfatal cardiovascular event during the trial, smoking, diastolic blood pressure, alcohol consumption, and serum cholesterol level (the last 4 adjustments were trial averages). CONCLUSION Work and marital stressors increase risk for mortality in men.
To Study, Analyze and predict the Diseases using Big Data

As we know in today’s life Twitter, Facebook, Google plus are well known social media now that user can use this application for different purposes. Nowadays many people have many social accounts Twitter is an online news and social networking service where users post and interact with messages, "tweets," limited to 140 characters. Registered users can write tweets, but those who are unregistered can only read them. Users access Twitter through its website or a mobile device app. Twitter is one of the growing social site that people are using for connecting, sharing with each other. There is number of short text messages posted by many people called as tweets. It is very hard to do analysis of social media data which has large amount of noisy, informal text of tweet messages and stream data.
Czech deverbal nouns : issues of their valency in linear and dependency corpora

For Czech language, corpora of two types exist: (i) a databank of linear texts, i.e. the Czech National Corpus (CNC in the sequel) at the Faculty of Arts, Charles University, Prague (this is a representative corpus of contemporary written Czech, a part of which, called SYN2000, contains about 100 million wordforms), and (ii) a dependency based treebank, i.e. the Prague Dependency Treebank, PDT in the sequel, which is a part of CNC annotated at several layers. The shallow-parsed shape of the latter, socalled analytical level, contains approx. 90 000 sentences. Both these corpora are annotated (by morphological tags in CNC, by syntactic functions in PDT) and both of them are available by search procedures (the Graphic interface for the Corpus Query Processor, GCQP in the sequel, was developed for searching strings of lemmas, words or morphemic tags through the CNC, and the NetGraph serves for searching sentence structures in PDT). The linear corpus is very useful for searching morphemic and lexical phenomena, including information about their frequency, but the dependency treebank is irreplaceable whenever one investigates syntactic relations in the sentence. Due to the high degree of "free" word order in Czech, many modifications can occur as either preceding or following their governors (exceptions of course exist, such as e.g. the non-congruent attributes with nouns). Thus it is very difficult to formulate a query about syntactic relations in the linear corpus. Even a very simple query about congruent (aggreeing) attributes with nouns (e.g. ([tag="A.MS1.*"] [tag="N.MS1.*"])) can give an incorrect result (e.g. Po bitvě je každý (Subject) generál (Nominal part of the predicate), lit. ‘After the battle, everyone is a general’, i.e. ‘Everyone is wise after the event’). It is surely more favourable to retrieve syntactical relations in the dependency treebank, but, comparing the size of both corpora, we see that it is still important to extract occurrences also from the linear one.
Sharing Domestic Life through Long-Term Video Connections

Video chat systems such as Skype, Google+ Hangouts, and FaceTime have been widely adopted by family members and friends to connect with one another over distance. We have conducted a corpus of studies that explore how various demographics make use of such video chat systems in which this usage moves beyond the paradigm of conversational support to one in which aspects of everyday life are shared over long periods of time, sometimes in an almost passive manner. We describe and reflect on studies of long-distance couples, teenagers, and major life events, along with design research focused on new video communication systems—the Family Window, Family Portals, and Perch—that explicitly support “always-on video” for awareness and communication. Overall, our findings show that people highly value long-term video connections and have appropriated them in a number of different ways. Designers of future video communication systems need to consider: ways of supporting the sharing of everyday life rather than just conversation, providing different design solutions for different locations and situations, providing appropriate audio control and feedback, and supporting expressions of intimacy over distance.
Rationalizing the Band Gap Tunability of Semiconductors via Electronic Structure Calculations

RATIONALIZING THE BAND GAP TUNABILITY OF SEMICONDUCTORS VIA ELECTRONIC STRUCTURE CALCULATIONS By Matthew N. Srnec August 2017 Dissertation supervised by Professor Jeffrey D. Evanseck. The polymorphs of titanium dioxide and various diamond-like semiconductor materials are promising candidates in photovoltaic solar cell applications. Several of these polymorphs have been studied with experimental and computational methods, which often aim at tuning the electronic structure, particularly the band gap value of the crystalline solid. Prior studies report that the addition of a substituent into the structure of titanium dioxide decreases its band gap value, but the reasons for this are unknown. Possible explanations for the change in band gap involve the substituent atom’s crystal radius, electronegativity, and ionization energy. Understanding the cause of these changes will provide great insight in designing new materials. The hypothesis of this work is that a substituent atom’s crystal radius has a greater impact on the change in band gap of titanium dioxide than the substituent atom’s electronegativity. In an aim to test this hypothesis, atoms of differing chemical properties were selected for substitution into the rutile and anatase polymorphs of titanium dioxide. The electronic structure (band structure and density of states) of the substituted
Recursive possibilistic fuzzy modeling

This paper suggests a recursive possibilistic approach for fuzzy modeling of time-varying processes. The approach is based on an extension of the possibilistic fuzzy c-means clustering and functional fuzzy rule-based modeling. Recursive possibilistic fuzzy modeling (rPFM) employs memberships and typicalities to cluster data. Functional fuzzy models uses affine functions in the fuzzy rule consequents. The parameters of the consequent functions are computed using the recursive least squares. Two classic benchmarks, Mackey-Glass time series and Box & Jenkins furnace data, are studied to illustrate the rPFM modeling and applicability. Data produced by a synthetic model with parameter drift is used to show the usefulness of rPFM to model time-varying processes. Performance of rPFM is compared with well established recursive fuzzy and neural fuzzy modeling and identification. The results show that recursive possibilistic fuzzy modeling produces parsimonious models with comparable or better accuracy than the alternative approaches.
Tracking vehicular speed variations by warping mobile phone signal strengths

In this paper, we consider the problem of tracking fine-grained speeds variations of vehicles using signal strength traces from GSM enabled phones. Existing speed estimation techniques using mobile phone signals can provide longer-term speed averages but cannot track short-term speed variations. Understanding short-term speed variations, however, is important in a variety of traffic engineering applications—for example, it may help distinguish slow speeds due to traffic lights from traffic congestion when collecting real time traffic information. Using mobile phones in such applications is particularly attractive because it can be readily obtained from a large number of vehicles. Our approach is founded on the observation that the large-scale path loss and shadow fading components of signal strength readings (signal profile) obtained from the mobile phone on any given road segment appear similar over multiple trips along the same road segment except for distortions along the time axis due to speed variations. We therefore propose a speed tracking technique that uses a Derivative Dynamic Time Warping (DDTW) algorithm to realign a given signal profile with a known training profile from the same road. The speed tracking technique then translates the warping path (i.e., the degree of stretching and compressing needed for alignment) into an estimated speed trace. Using 6.4 hours of GSM signal strength traces collected from a vehicle, we show that our algorithm can estimate vehicular speed with a median error of ± 5mph compared to using a GPS and can capture significant speed variations on road segments with a precision of 68% and a recall of 84%.
Frequent mitotic errors in tumor cells of genetically micro-heterogeneous glioblastomas

Glioblastoma multiforme (GBM) is characterized by intratumoral heterogeneity as to both histomorphology and genetic changes, displaying a wide variety of numerical chromosome aberrations the most common of which are monosomy 10 and trisomy 7. Moreover, GBM in vitro are known to have variable karyotypes within a given tumor cell culture leading to rapid karyotype evolution through a high incidence of secondary numerical chromosome aberrations. The aim of our study was to investigate to what extent this mitotic instability of glioblastoma cells is also present in vivo. We assessed the spatial distribution patterns of numerical chromosome aberrations in vivo in a series of 24 GBM using two-color in situ hybridization for chromosomes 7/10, 8/17, and 12/18 on consecutive 6-µm paraffin-embedded tissue slides. The chromosome aberration patterns were compared with the histomorphology of the investigated tumor assessed from a consecutive HE-stained section, and with the in vitro karyotype of cell cultures established from the tumors. All investigated chromosomes showed mitotic instability, i.e., numerical aberrations within significant amounts of tumor cells in a scattered distribution through the tumor tissue. As to chromosomes 10 and 17, only monosomy occurred, as to chromosome 7 only trisomy/polysomy, apparently as a result of selection in favor of the respective aberration. Conversely, chromosomes 8, 12, and 18 displayed scattered patterns of monosomy as well as trisomy within a given tumor reflecting a high mitotic error rate without selective effects. The karyotypes of the tumor cell cultures showed less variability of numerical aberrations apparently due to clonal adaptation to in vitro conditions. We conclude that glioblastoma cells in vivo are characterized by an extensive tendency to mitotic errors. The resulting clonal diversity of chromosomally aberrant cells may be an important biological constituent of the well-known ability of glioblastomas to preserve viable tumor cell clones under adaptive stress in vivo, in clinical terms to rapidly recur after antitumoral therapy including radio- or chemotherapy.
Consistent Algorithms for Clustering Time Series

The problem of clustering is considered for the case where every point is a time series. The time series are either given in one batch (offline setting), or they are allowed to grow with time and new time series can be added along the way (online setting). We propose a natural notion of consistency for this problem, and show that there are simple, computationally efficient algorithms that are asymptotically consistent under extremely weak assumptions on the distributions that generate the data. The notion of consistency is as follows. A clustering algorithm is called consistent if it places two time series into the same cluster if and only if the distribution that generates them is the same. In the considered framework the time series are allowed to be highly dependent, and the dependence can have arbitrary form. If the number of clusters is known, the only assumption we make is that the (marginal) distribution of each time series is stationary ergodic. No parametric, memory or mixing assumptions are made. When the number of clusters is unknown, stronger assumptions are provably necessary, but it is still possible to devise nonparametric algorithms that are consistent under very general conditions. The theoretical findings of this work are illustrated with experiments on both synthetic and real data.
Performance of Correspondence Algorithms in Vision-Based Driver Assistance Using an Online Image Sequence Database

This paper discusses options for testing correspondence algorithms in stereo or motion analysis that are designed or considered for vision-based driver assistance. It introduces a globally available database, with a main focus on testing on video sequences of real-world data. We suggest the classification of recorded video data into situations defined by a cooccurrence of some events in recorded traffic scenes. About 100-400 stereo frames (or 4-16 s of recording) are considered a basic sequence, which will be identified with one particular situation. Future testing is expected to be on data that report on hours of driving, and multiple hours of long video data may be segmented into basic sequences and classified into situations. This paper prepares for this expected development. This paper uses three different evaluation approaches (prediction error, synthesized sequences, and labeled sequences) for demonstrating ideas, difficulties, and possible ways in this future field of extensive performance tests in vision-based driver assistance, particularly for cases where the ground truth is not available. This paper shows that the complexity of real-world data does not support the identification of general rankings of correspondence techniques on sets of basic sequences that show different situations. It is suggested that correspondence techniques should adaptively be chosen in real time using some type of statistical situation classifiers.
Distributed cache replacement for caching-enable base stations in cellular networks

Distributive service data storage at the caching-enabled base stations (BSs) can reduce the traffic load in future cellular networks. Taking the limited caching space into account, it is necessary for the BSs to adjust their caching data based on service popularity in order to achieve better caching efficiency. In this paper, we investigate the cache replacement strategy for BSs to minimize the transmission cost between BSs in cellular networks. The cache replacement problem is modelled as a Markov Decision Process (MDP). Without extra information exchange about caching data between the BSs, we propose a distributed cache replacement strategy based on Q-learning. Especially, we calculate the transmission cost for possible cache replacement actions according to the previous data request and transmission between BSs. The convergence of the proposed distributed cache replacement strategy is proved by sequential stage game model. Simulation results verify the convergence of the proposed cache replacement strategy and show its performance gain compared to conventional strategies.
A relative map filter using linear invariant measurements

In this paper, a new relative map algorithm is presented. The algorithm extracts linear invariant measurements from original laser scan data and uses an information filter to update the absolute map. The algorithm avoids the procedure of building the relative map, which is a basic procedure in other relative map algorithms. This improvement makes the new algorithm avoid the problem of inconsistency, which is inherent in other relative map algorithms. The requirements of computation and memory of this algorithm are linear over the size of the map, which are the same as RMGF. However, our algorithm has a simpler structure and performs faster. Experimental result on a simulated map demonstrates the advantages of our algorithm.
A Multilevel Approach to the Relationship Between Birth Order and Intelligence

Many studies show relationships between birth order and intelligence but use cross-sectional designs or manifest other threats to internal validity. Multilevel analyses with a control variable show that when these threats are removed, two major results emerge: (a) birth order has no significant influence on children's intelligence and (b) earlier reported birth order effects on intelligence are attributable to factors that vary between, not within, families. Analyses on 7- to8 - and 13- to 14-year-old children from the National Longitudinal Survey of Youth support these conclusions. When hierarchical data structures, age variance of children, and within-family versus between-family variance sources are taken into account, previous research is seen in a new light.
Do the dose or route of administration of norethisterone acetate as a part of hormone therapy play a role in risk of breast cancer: National‐wide case‐control study from Finland

We examined the associations between various doses and routes of administration of norethisterone acetate (NETA) in estrogen–progestagen therapy (EPT) and the risk of breast cancer in Finland. All Finnish women with first invasive breast cancer diagnosed between the ages of 50–62 during 1995–2007 (n = 9,956) were identified from the Finnish Cancer Registry. For each case, 3 controls of the same age were retrieved from the Finnish Population Register. The use of estradiol+NETA‐therapy by the cases and controls was traced from the national Medical Reimbursement Registry. The data were analyzed with multivariate conditional logistic regression, adjusting for parity, age at the first birth, and health care district. The continuous mode of NETA use tended to be associated with a higher rate ratio for breast cancer than the sequential use. The use of continuous “low” dose (NETA 0.5 mg + estradiol 1.0 mg) was associated with an increased rate ratio of breast cancer already in less than 3 years of use (odds ratio 1.94; 95% confidence interval 1.39–2.70) while a risk elevation for “high” dose (NETA 1.0 mg + estradiol 2.0 mg) was seen after 3 years use (1.71; 1.51–2.54). Oral and transdermal use of NETA were accompanied with comparable risks for breast cancer. In conclusion, the dose or route of administration of NETA in EPT do not modify the risks for breast cancer.
Glutaredoxin 2 (Grx2) Gene Deletion Induces Early Onset of Age-dependent Cataracts in Mice*

Background: Mitochondrial glutaredoxin 2 is a member of the oxidoreductase family with disulfide reductase activity that repairs thiol oxidation-damaged proteins. Results: Glutaredoxin 2 null mice develop early cataracts during aging. Conclusion: Glutaredoxin 2 deletion causes mitochondrial malfunction and cataract formation and is a good model for studying the mechanism of human age-related cataracts. Significance: Thiol oxidation repair system is essential for lens transparency. Glutaredoxin 2 (Grx2) is an isozyme of glutaredoxin1 (thioltransferase) present in the mitochondria and nucleus with disulfide reductase and peroxidase activities, and it controls thiol/disulfide balance in cells. In this study, we investigated whether Grx2 gene deletion could induce faster age-related cataract formation and elucidated the biochemical changes effected by Grx2 gene deletion that may contribute to lens opacity. Slit lamp was used to examine the lenses in Grx2 knock-out (KO) mice and age-matched wild-type (WT) mice ages 1 to 16 months. In the Grx2 null mice, the lens nuclear opacity began at 5 months, 3 months sooner than that of the control mice, and the progression of cataracts was also much faster than the age-matched controls. Lenses of KO mice contained lower levels of protein thiols and GSH with a significant accumulation of S-glutathionylated proteins. Actin, αA-crystallin, and βB2-crystallin were identified by Western blot and mass spectroscopy as the major S-glutathionylated proteins in the lenses of 16-month-old Grx2 KO mice. Compared with the WT control, the lens of Grx2 KO mice had only 50% of the activity in complex I and complex IV and less than 10% of the ATP pool. It was concluded that Grx2 gene deletion altered the function of lens structural proteins through S-glutathionylation and also caused severe disturbance in mitochondrial function. These combined alterations affected lens transparency.
Combining biased random sampling with metaheuristics for the facility location problem in distributed computer systems

This paper introduces a probabilistic algorithm for solving the well-known Facility Location Problem (FLP), an optimization problem frequently encountered in practical applications in fields such as Logistics or Telecommunications. Our algorithm is based on the combination of biased random sampling -using a skewed probability distribution- with a metaheuristic framework. The use of random variates from a skewed distribution allows to guide the local search process inside the metaheuristic framework which, being a stochastic procedure, is likely to produce slightly different results each time it is run. Our approach is validated against some classical benchmarks from the FLP literature and it is also used to analyze the deployment of service replicas in a realistic Internet-distributed system.
Regulation and Localization of the Bloom Syndrome Protein in Response to DNA Damage

Bloom syndrome (BS) is an autosomal recessive disorder characterized by a high incidence of cancer and genomic instability. BLM, the protein defective in BS, is a RecQ-like helicase, presumed to function in DNA replication, recombination, or repair. BLM localizes to promyelocytic leukemia protein (PML) nuclear bodies and is expressed during late S and G2. We show, in normal human cells, that the recombination/repair proteins hRAD51 and replication protein (RP)-A assembled with BLM into a fraction of PML bodies during late S/G2. Biochemical experiments suggested that BLM resides in a nuclear matrix–bound complex in which association with hRAD51 may be direct. DNA-damaging agents that cause double strand breaks and a G2 delay induced BLM by a p53- and ataxia-telangiectasia mutated independent mechanism. This induction depended on the G2 delay, because it failed to occur when G2 was prevented or bypassed. It coincided with the appearance of foci containing BLM, PML, hRAD51 and RP-A, which resembled ionizing radiation-induced foci. After radiation, foci containing BLM and PML formed at sites of single-stranded DNA and presumptive repair in normal cells, but not in cells with defective PML. Our findings suggest that BLM is part of a dynamic nuclear matrix–based complex that requires PML and functions during G2 in undamaged cells and recombinational repair after DNA damage.