Miracle-dz/UniFAR-FTUs huggingface dataset:
Effectiveness of adjunctive antidepressant treatment for bipolar depression.

BACKGROUND Episodes of depression are the most frequent cause of disability among patients with bipolar disorder. The effectiveness and safety of standard antidepressant agents for depressive episodes associated with bipolar disorder (bipolar depression) have not been well studied. Our study was designed to determine whether adjunctive antidepressant therapy reduces symptoms of bipolar depression without increasing the risk of mania. METHODS In this double-blind, placebo-controlled study, we randomly assigned subjects with bipolar depression to receive up to 26 weeks of treatment with a mood stabilizer plus adjunctive antidepressant therapy or a mood stabilizer plus a matching placebo, under conditions generalizable to routine clinical care. A standardized clinical monitoring form adapted from the mood-disorder modules of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, fourth edition, was used at all follow-up visits. The primary outcome was the percentage of subjects in each treatment group meeting the criterion for a durable recovery (8 consecutive weeks of euthymia). Secondary effectiveness outcomes and rates of treatment-emergent affective switch (a switch to mania or hypomania early in the course of treatment) were also examined. RESULTS Forty-two of the 179 subjects (23.5%) receiving a mood stabilizer plus adjunctive antidepressant therapy had a durable recovery, as did 51 of the 187 subjects (27.3%) receiving a mood stabilizer plus a matching placebo (P=0.40). Modest nonsignificant trends favoring the group receiving a mood stabilizer plus placebo were observed across the secondary outcomes. Rates of treatment-emergent affective switch were similar in the two groups. CONCLUSIONS The use of adjunctive, standard antidepressant medication, as compared with the use of mood stabilizers, was not associated with increased efficacy or with increased risk of treatment-emergent affective switch. Longer-term outcome studies are needed to fully assess the benefits and risks of antidepressant therapy for bipolar disorder. (ClinicalTrials.gov number, NCT00012558 [ClinicalTrials.gov].).
Yra1p, a conserved nuclear RNA‐binding protein, interacts directly with Mex67p and is required for mRNA export

Mex67p and Mtr2p constitute an essential mRNA export complex that interacts with poly(A)+ RNA and nuclear pore proteins. We have identified Yra1p, an intranuclear protein with in vitro RNA–RNA annealing activity, which directly binds to Mex67p. The complex between Yra1p and Mex67p was reconstituted in vitro and shown by UV‐crosslinking to bind directly to RNA. Mutants of YRA1 are impaired in nuclear poly(A)+ RNA export at restrictive growth conditions. ALY, the mouse homologue of Yra1p and a transcriptional co‐activator, can bind in vitro to yeast and human Mex67p and partly complements the otherwise non‐viable yra1 null mutant. Thus, Yra1p is the first RNA‐binding protein characterized, which bridges the shuttling Mex67p/Mtr2p exporter to intranuclear mRNA transport cargoes.
Familial Aggregation in Constipated Subjects in a Tertiary Referral Center

OBJECTIVES:Clinical observation showed that there is family aggregation in constipated subjects, but formal data are lacking. This prompted us to conduct a formal family study in constipated subjects.METHODS:Constipated subjects (probands) were identified according to the Rome II and Chinese constipation questionnaire criteria, healthy subjects were chosen as controls. Living first-degree relatives (parents, siblings, and children) and spouses (as internal controls) from both groups were identified. The questionnaire on Rome II criteria was given to the relatives either through the index subjects or by mail. The questionnaire was received by mailing back or through the index subjects. Any nonresponders were chased.RESULTS:There were 132 probands with constipation and 114 controls. The Rome II questionnaire was sent to a total of 677 relatives of the probands and 591 of the controls. Relatives were comparable in mean age, sex distribution, family size, and marital status in the two groups. Constipation prevalence was 16.4% in probands' relatives versus 9.1% in controls' relatives, i.e., 13% in the relatives from both proband and controls. Among the constipated relatives, 6.3% versus 9.3% of the relatives were spouses of the probands and controls (P = 0.5). Subjects with more family members having constipation will have higher risk of constipation: OR 2.02, CI 1.14–3.65, P = 0.0177 for at least one family member; OR 3.99, CI 1.86–9.23, P = 0.0006 for at least two family members.CONCLUSIONS:Familial aggregation of constipation occurs, supporting a genetic or intrafamilial environment component.
Structural Plasticity Underlies Experience-Dependent Functional Plasticity of Cortical Circuits

The stabilization of new spines in the barrel cortex is enhanced after whisker trimming, but its relationship to experience-dependent plasticity is unclear. Here we show that in wild-type mice, whisker potentiation and spine stabilization are most pronounced for layer 5 neurons at the border between spared and deprived barrel columns. In homozygote αCaMKII-T286A mice, which lack experience-dependent potentiation of responses to spared whiskers, there is no increase in new spine stabilization at the border between barrel columns after whisker trimming. Our data provide a causal link between new spine synapses and plasticity of adult cortical circuits and suggest that αCaMKII autophosphorylation plays a role in the stabilization but not formation of new spines.
Evaluation of Latent Semantic Vector Models Using a Swedish Word Comprehension Test

This paper presents an evaluation of latent semantic vector models trained with different corpora and parameter settings. The important result is how the performance of the model changes depending on various parameters when the evaluation is not only the usual information retrieval testbed, but a word comprehension test. The new evaluation set may also be of interest for other researchers since evaluation sets for Swedish vector models is not very common.
Malocclusion and early orthodontic treatment requirements in the mixed dentitions of a population of Nigerian children

Introduction: The aims of this study were to establish the prevalence of dental features that indicate a need for early intervention and to ascertain the prevalence of different methods of early treatment among a population of Nigerian children in mixed dentition. Methods: Occlusal relationships were evaluated in 101 children in mixed dentition between the ages of 6 and 12 years who presented at the Orthodontic Unit, Department of Child Dental Health, Lagos University Teaching Hospital over a 2 years period. The need for different modes of early orthodontic treatment was also recorded. Results: Anterior tooth rotations (61.4%) and increased overjet (44.6%) were the most prevalent occlusal anomalies. Others included deep bite (31.7%), reverse overjet (13.9%), and anterior open bite (14.8%). Severe maxillary spacing and crowding were exhibited in 12.0% and 5.0%, respectively. About a third (35.7%) of the subjects presented with crossbite while lip incompetence was observed in 43.6% of the subjects. About 44% of the subjects also presented with various oral habits with digit (15.8%) and lip sucking (9.9%) being the most prevalent. Subjects were recommended for treatment with 2 by 4 fixed orthodontic appliances (22.3%), habit breakers (20.7%), removable orthodontic appliances (16.5%), and extractions (15.7%). Conclusions: Increased overjet and anterior tooth rotation were the majority of occlusal anomalies seen, which are not only esthetically displeasing but may also cause an increased susceptibility to trauma to these teeth. Treatment options varied from extractions only to the use of appliance therapy.
Clinic Study of Correlation Between Myeloperoxidase and Acute Coronary Syndrome

Objective To study whether myeloperoxidase (MPO) can provide prognostic information in patients with acute coronary syndromes (ACS). Methods The study population consisted of 274 consecutive patients with ACS. All patients underwent coronary angiography which showed significant coronary artery disease and blood samples were collected at admission. Follow-ups were scheduled at 1, 3, and 6 months.The end point included cardiac death, acute myocardial infarction (MI), percutaneous or surgical revascularization. Results Patients with elevated MPO serum levels (MPO ≥ 72.2 AUU/L) were more likely to have diabetics and had a history of coronary events. Kaplan-Meier event rate curves with accumulative incidence of end point at 6-month follow-up in the MPO ≥ 72.2 AUU/L group was significantly higher than in MPO<72.2 AUU/L group. Conclusions MPO may be a powerful predictor of adverse outcome in patients with ACS. Key Words myeloperoxidase; acute coronary syndromes
Creating Access to the General Curriculum With Links to Grade-Level Content for Students With Significant Cognitive Disabilities

Current federal policy requires that students with disabilities participate in large-scale assessments and be included in schools' scores for adequate yearly progress. Students with significant cognitive disabilities may participate in an alternate assessment with alternate achievement standards, but these standards must be linked to grade-level content and promote access to the general curriculum. Because most research with this population has focused on nonacademic life skills, few guidelines exist for teaching and assessing skills that are linked to grade-level content. One challenge to developing research and practice in grade-linked academic content for students with significant cognitive disabilities is the absence of a clear conceptual framework. This article—developed by a team of special education, curriculum content, and measurement experts—proposes a conceptual definition and criteria for linking instruction and assessment to grade-level academic content.
Bothrops jararaca Peptide with Anti-Hypertensive Action Normalizes Endothelium Dysfunction Involved in Physiopathology of Preeclampsia

Preeclampsia, a pregnancy-specific syndrome characterized by hypertension, proteinuria and edema, is a major cause of fetal and maternal morbidity and mortality especially in developing countries. Bj-PRO-10c, a proline-rich peptide isolated from Bothrops jararaca venom, has been attributed with potent anti-hypertensive effects. Recently, we have shown that Bj-PRO-10c-induced anti-hypertensive actions involved NO production in spontaneous hypertensive rats. Using in vitro studies we now show that Bj-PRO-10c was able to increase NO production in human umbilical vein endothelial cells from hypertensive pregnant women (HUVEC-PE) to levels observed in HUVEC of normotensive women. Moreover, in the presence of the peptide, eNOS expression as well as argininosuccinate synthase activity, the key rate-limiting enzyme of the citrulline-NO cycle, were enhanced. In addition, excessive superoxide production due to NO deficiency, one of the major deleterious effects of the disease, was inhibited by Bj-PRO-10c. Bj-PRO-10c induced intracellular calcium fluxes in both, HUVEC-PE and HUVEC, which, however, led to activation of eNOS expression only in HUVEC-PE. Since Bj-PRO-10c promoted biological effects in HUVEC from patients suffering from the disorder and not in normotensive pregnant women, we hypothesize that Bj-PRO-10c induces its anti-hypertensive effect in mothers with preeclampsia. Such properties may initiate the development of novel therapeutics for treating preeclampsia.
Activin increases the number of synaptic contacts and the length of dendritic spine necks by modulating spinal actin dynamics

Long-lasting modifications in synaptic transmission depend on de novo gene expression in neurons. The expression of activin, a member of the transforming growth factor β (TGF-β) superfamily, is upregulated during hippocampal long-term potentiation (LTP). Here, we show that activin increased the average number of presynaptic contacts on dendritic spines by increasing the population of spines that were contacted by multiple presynaptic terminals in cultured neurons. Activin also induced spine lengthening, primarily by elongating the neck, resulting in longer mushroom-shaped spines. The number of spines and spine head size were not significantly affected by activin treatment. The effects of activin on spinal filamentous actin (F-actin) morphology were independent of protein and RNA synthesis. Inhibition of cytoskeletal actin dynamics or of the mitogen-activated protein (MAP) kinase pathway blocked not only the activin-induced increase in the number of terminals contacting a spine but also the activin-induced lengthening of spines. These results strongly suggest that activin increases the number of synaptic contacts by modulating actin dynamics in spines, a process that might contribute to the establishment of late-phase LTP.
Power-Proxying on the NIC: A Case Study with the Gnutella File-Sharing Protocol

Edge devices such as desktop and laptop computers constitute a majority of the devices connected to the Internet today. Peer-to-peer (P2P) file-sharing applications generally require edge devices to maintain network presence whenever possible to enhance the robustness of the file-sharing network, which in turn can lead to considerable wastage of energy. We show that energy can be saved by permitting edge devices to enter into standby state and still maintain network connectivity by proxying protocols in the network interface card (NIC)
Fluid sketches: continuous recognition and morphing of simple hand-drawn shapes

We describe a new sketching interface in which shape recognition and morphing are tightly coupled. Raw input strokes are continuously morphed into ideal geometric shapes, even before the pen is lifted. By means of smooth and continual shape transformations the user is apprised of recognition progress and the appearance of the final shape, yet always retains a sense of control over the process. At each time t the system uses the trajectory traced out thus far by the pen coupled with the current appearance of the time-varying shape to classify the sketch as one of several pre-defined basic shapes. The recognition operation is performed using shape-specific fits based on least-squares or relaxation, which are continuously updated as the user draws. We describe the time-dependent transformation of the sketch, beginning with the raw pen trajectory, using a family of first-order ordinary differential equations that depend on time and the current shape of the sketch. Using this formalism, we describe several possible behaviors that result by varying the relative significance of new and old portions of a stroke, changing the “viscosity” of the morph, and enforcing different end conditions. A preliminary user study suggests that the new interface is particularly effective for rapidly constructing diagrams consisting of simple shapes.
An Easy-to-Interface CDC With an Efficient Automatic Calibration

A new capacitance-to-digital converter (CDC) that gives a digital output proportional to the measurand kx, independent of its nominal capacitance, is reported in this paper. Various CDCs are available in the market, but their output is a function of the nominal value C0 of the sensor. Thus, a manual correction is required in the output, whenever a new capacitive sensor is interfaced to such CDCs. Moreover, the C0 of the sensors is usually a large value compared with the change in capacitance due to kx. Thus, in a typical CDC, a large percentage of the output counts/bits is used to measure and represent the C0 leading to an underutilization of the hardware as far as the measurement of kx is concerned. The proposed CDC uses a new automatic calibration (AC), employing a switched-capacitor (SC) circuit-based voltage source in a feedback topology, and provides an output independent of the C0 of the sensor employed. The proposed CDC is based on an SC dual-slope technique and possesses the advantages of the dual-slope conversion method. The CDC circuit is designed such that the entire full scale can be used for representing the change in the kx. In addition to this advantage, the AC helps to remove the dependence on the accuracy of the reference capacitor employed in the CDC. A detailed analysis of the effect of various sources of errors in the CDC has been conducted and presented in this paper. A prototype of the proposed CDC has been developed and tested. The results obtained show that the output of the CDC is not a function of the C0 (C0 varied from 60 pF to 1.46 nF) of the sensors interfaced.
Functional Magnetic Resonance Imaging and Functional Near-Infrared Spectroscopy: Insights from Combined Recording Studies

Although blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) is a widely available, non-invasive technique that offers excellent spatial resolution, it remains limited by practical constraints imposed by the scanner environment. More recently, functional near infrared spectroscopy (fNIRS) has emerged as an alternative hemodynamic-based approach that possesses a number of strengths where fMRI is limited, most notably in portability and higher tolerance for motion. To date, fNIRS has shown promise in its ability to shed light on the functioning of the human brain in populations and contexts previously inaccessible to fMRI. Notable contributions include infant neuroimaging studies and studies examining full-body behaviors, such as exercise. However, much like fMRI, fNIRS has technical constraints that have limited its application to clinical settings, including a lower spatial resolution and limited depth of recording. Thus, by combining fMRI and fNIRS in such a way that the two methods complement each other, a multimodal imaging approach may allow for more complex research paradigms than is feasible with either technique alone. In light of these issues, the purpose of the current review is to: (1) provide an overview of fMRI and fNIRS and their associated strengths and limitations; (2) review existing combined fMRI-fNIRS recording studies; and (3) discuss how their combined use in future research practices may aid in advancing modern investigations of human brain function.
Partial Multi-View Clustering using Graph Regularized NMF

Real-world datasets consist of data representations (views) from different sources which often provide information complementary to each other. Multi-view learning algorithms aim at exploiting the complementary information present in different views for clustering and classification tasks. Several multi-view clustering methods that aim at partitioning objects into clusters based on multiple representations of the object have been proposed. Almost all of the proposed methods assume that each example appears in all views or at least there is one view containing all examples. In real-world settings this assumption might be too restrictive. Recent work on Partial View Clustering addresses this limitation by proposing a Non-negative Matrix Factorization based approach called PVC. Our work extends the PVC work in two directions. First, the current PVC algorithm is designed specifically for two-view datasets. We extend this algorithm for the k partial-view scenario. Second, we extend our k partial-view algorithm to include view specific graph laplacian regularization. This enables the proposed algorithm to exploit the intrinsic geometry of the data distribution in each view. The proposed method, which is referred to as GPMVC (Graph Regularized Partial Multi-View Clustering), is compared against 7 baseline methods (including PVC) on 5 publicly available text and image datasets. In all settings the proposed GPMVC method outperforms all baselines. For the purpose of reproducibility, we provide access to our code.
Chan Location Algorithm Application in 3-Dimension Space Location

Wireless location algorithm based on TOA/TDOA has been researched and compared, and precise ranging technology based on TOA has been analyzed in this paper. In view of the existing location algorithm is always in 2-dimension form, Chan algorithm has been concluded in 3-dimension form and a 3-dimension location method based on TOA is proposed. The method transforms the nonlinear location equation into linear form by using initialization estimation coming from two-step weighed least square, then calculates the location estimation. The method is simple and precise. The simulation about it is given to show its theoretic value.
Complex decongestive physiotherapy for patients with chronic cancer-associated lymphedema.

BACKGROUND AND PURPOSE Lymphedema of the limbs after cancer therapy is the most common cause of lymphedema in developed countries. There is no cure for chronic cancer-associated lymphedema. Multidisciplinary complex decongestive physiotherapy (CDP) is commonly used as a primary treatment. This prospective study assessed the efficacy of intensive CDP treatment in chronic cancer-associated lymphedema. METHODS Thirty women who had unilateral upper or lower limb chronic lymphedema after breast or pelvic cancer therapy were enrolled in the study. All patients received CDP once per day, in consecutive full treatment sessions, which took place between 4 and 21 times. Assessment of the results of therapy included measuring the circumference, calculated volume, and edema ratio (excess volume/unaffected side volume) of the limb volume. The main outcome measure was the percentage reduction in excess limb volume. RESULTS The pretreatment edema ratio demonstrated a high correlation with the patient's age (r = 0.508, p = 0.004) and the duration of the lymphedema (r = 0.634, p < 0.000). After the intensive CDP, the limb circumference, calculated volume, and edema ratio were significantly reduced compared with their pretreatment values (p < 0.000). The mean percentage reduction of excess volume was 67.8 +/- 33.2% in all patients. CONCLUSIONS Intensive CDP was effectively able to reduce the limb volume of patients with chronic cancer-associated lymphedema. Further follow-up study is needed to confirm the effectiveness of CDP in the maintenance phase, and its long-term effectiveness in Taiwanese.