Miracle-dz/UniFAR-FTUs huggingface dataset:
Developing anti‐HER2 vaccines: Breast cancer experience

Breast cancer accounts for more than one million new cases annually and is the leading cause of death in women globally. HER2 overexpression induces cellular and humoral immune responses against the HER2 protein and is associated with higher tumor proliferation rates. Trastuzumab‐based therapies are effectively and widely used as standard of care in HER2‐amplified/overexpressed breast cancer patients; one cited mechanism of action is the induction of passive immunity and antibody‐dependent cellular cytotoxicity against malignant breast cancer cells. These findings drove the efforts to generate antigen‐specific immunotherapy to trigger the patient's immune system to target HER2‐overexpressing tumor cells, which led to the development of various vaccines against the HER2 antigen. This article discusses the various anti‐HER2 vaccine formulations and strategies and their potential role in the metastatic and adjuvant settings.
Design and Development of a House-Mobile Security System

The objective of this work is to design, develop and implement an alarm system that triggers the alarm and alerts the owner via a mobile text message if the house has been opened or an attempt has been made to open it illegally. The system will also feature two different forms of activation/deactivation and will automatically open or close the door for the user. The advantages of this house-mobile security system (HMSS) are its high security level, robustness, low cost and ease of use (uncomplicated) and that there is no distance limitation for contact. The system integrates different sensors via a microcontroller, which is the brain of the system, in order to avoid the problem of false alarms sent by other alarm monitoring systems to ‘Alarm Receiving Centers’ or Police departments. The HMSS is useful in homes, small businesses, offices, warehouses, etc.
Broadcast channels with confidential messages by randomness constrained stochastic encoder

In coding schemes for the wire-tap channel or the broadcast channels with confidential messages, it is well known that the sender needs to use a stochastic encoding to avoid the information about the transmitted confidential message to be leaked to an eavesdropper. In this paper, it is investigated that the trade-off between the rate of the random number to realize the stochastic encoding and the rates of the common, private, and confidential messages. For the direct theorem, the superposition coding scheme for the wire-tap channel recently proposed by Chia and El Gamal is employed, and its strong security is proved. The matching converse theorem is also established. Our result clarifies that a combination of the ordinary stochastic encoding and the channel prefixing by the channel simulation is suboptimal.
Waking up too early – the consequences of preterm birth on sleep development

Good quality sleep of sufficient duration is vital for optimal physiological function and our health. Sleep deprivation is associated with impaired neurocognitive function and emotional control, and increases the risk for cardiometabolic diseases, obesity and cancer. Sleep develops during fetal life with the emergence of a recognisable pattern of sleep states in the preterm fetus associated with the development, maturation and connectivity within neural networks in the brain. Despite the physiological importance of sleep, surprisingly little is known about how sleep develops in individuals born preterm. Globally, an estimated 15 million babies are born preterm (<37 weeks gestation) each year, and these babies are at significant risk of neural injury and impaired brain development. This review discusses how sleep develops during fetal and neonatal life, how preterm birth impacts on sleep development to adulthood, and the factors which may contribute to impaired brain and sleep development, leading to altered neurocognitive, behavioural and motor capabilities in the infant and child. Going forward, the challenge is to identify specific risk factors for impaired sleep development in preterm babies to allow for the design of interventions that will improve the quality and quantity of sleep throughout life.
Driver behavioral cloning using deep learning

In this paper, one solution for driver behavioral cloning using deep learning is presented. The aim of this paper is to achieve autonomous driving in simulated conditions. In the simulator, images obtained from a camera mounted in the vehicle mimics the driver's vision, and then the reaction, control of the vehicle. Based on the images from the cameras gained in the manual mode, the neural network is trained using deep learning. Using this trained deep neural network leads to autonomous driving. The driver behavioral cloning algorithm, developed and described in this paper, is based on the NVIDIA convolutional neural network model.
Aspects of modality in audio-visual processes 1

The relevance of the sensory modality in which information processing is initiated is not an issue that has received much attention in cognitive psychology. Much in the spirit of information processing approaches to cognition, psychological content is conceived as abstract. Mathematical approaches to information processing have likewise not made much room for conceptualizing the specific contribution of the sensory input modalities. Bi-modal speech processing is among the best explored cases, yet it is not clear that investigations of speech processing in another modality than the canonical auditory one, i.e., lipreading, have so far departed from the mainstream information processing frameworks. A more recent theoretical proposal which casts information processing as being a matter of separate modules or of separate content domains leaves room for modality specificity. Against this background two apparently related phenomena are discussed, McGurk effects and ventriloquism. Starting from models that neither postulate modality specific processes nor modality specific representations, the paper asks whether a distinction is needed between content driven and contiguity driven processes.
Uncertainty-Aware Elastic Virtual Machine Scheduling for Stream Processing Systems

Stream processing systems deployed on the cloud need to be elastic to effectively accommodate workload variations over time. Performance models can predict maximum sustainable throughput (MST) as a function of the number of VMs allocated. We present a scheduling framework that incorporates three statistical techniques to improve Quality of Service (QoS) of cloud stream processing systems: (i) uncertainty quantification to consider variance in the MST model; (ii) online learning to update MST model as new performance metrics are gathered; and (iii) workload models to predict input data stream rates assuming regular patterns occur over time. Our framework can be parameterized by a QoS satisfaction target that statistically finds the best performance/cost tradeoff. Our results illustrate that each of the three techniques alone significantly improves QoS, from 52% to 73-81% QoS satisfaction rates on average for eight benchmark applications. Furthermore, applying all three techniques allows us to reach 98.62% QoS satisfaction rate with a cost less than twice the cost of the optimal (in hindsight) VM allocations, and half of the cost of allocating VMs for the peak demand in the workload.
Longitudinal Analysis of Attitudes Toward Wolves

Understanding individual attitudes and how these predict overt opposition to predator conservation or direct, covert action against predators will help to recover and maintain them. Studies of attitudes toward wild animals rely primarily on samples of individuals at a single time point. We examined longitudinal change in individuals’ attitudes toward gray wolves (Canis lupus). In the contiguous United States, amidst persistent controversy and opposition, abundances of gray wolves are at their highest in 60 years. We used mailed surveys to sample 1892 residents of Wisconsin in 2001 or 2004 and then resampled 656 of these individuals who resided in wolf range in 2009. Our study spanned a period of policy shifts and increasing wolf abundance. Over time, the 656 respondents increased agreement with statements reflecting fear of wolves, the belief that wolves compete with hunters for deer (Odocoileus virginianus), and inclination to poach a wolf. Endorsement of lethal control of wolves by the state and public hunting of wolves also increased. Neither the time span over which respondents reported exposure to wolves locally nor self‐reported losses of domestic animals to wolves correlated with changes in attitude. We predict future increases in legal and illegal killing of wolves that may reduce their abundance in Wisconsin unless interventions are implemented to improve attitudes and behavior toward wolves. To assess whether interventions change attitudes, longitudinal studies like ours are needed.
The Personalities of Twins: Just Ordinary Folks

Abstract Twin studies have demonstrated that personality traits show moderate genetic influence. The conclusions drawn from twin studies rely on the assumptions that twins are representative of the population at large and that monozygotic and dizygotic twins are comparable in every way that might have bearing on the traits being studied. To evaluate these assumptions, we used Multidimensional Personality Questionnaire (MPQ) data from three samples drawn from the Minnesota Twin Registry (totaling 12,971 respondents) to examine the effect sizes associated with mean differences on the 11 MPQ scales and 3 higher-order MPQ factors for singletons versus twins and MZ twins versus DZ twins. The singletons in the samples were family members of the participating twins. We also used ratios of scale variances to examine the significance of variance differences. The only mean or variance difference replicated across all three samples was greater Social Closeness (about .1 standard deviation) for twins than for singletons. This difference was obtained for both males and females. It would appear that, with respect to personality, twins are not systematically different from other people. Our results also highlight the importance of replication in psychological research because each of our large samples showed differences not replicated in other samples.
An empirical study on price rigidity

This paper uses unpublished retailer-level microdata underlying UK consumer price indices to investigate price rigidity. Based on the conventional method, little rigidity is found in frequency of price change, since the implied price duration is only 5.5 months. However, it significantly underestimates the true duration (9.3 months) as suggested by cross-sectional method. Results also exhibit conspicuous heterogeneities in rigidity across sectors and shop types but weak difference across regions and time. The overall distribution of duration can be decomposed by sector into a decreasing component and a cyclical component with 4-month cycles. Both time and state dependent features exist in pricing. These findings support New Keynesian theories and enable a better calibration to improve the performances of macroeconomic models.
The Concept of Networkability - How to Make Companies Competitive in Business Networks

Business networking the management of ITenabled relationships between internal and external business partners is one of the most important features of enterprises in the information age. Currently, business networking is moving into the center of business engineering and aims at preparing enterprises in becoming part of IT-based business networks and in exploiting new process efficiencies and business opportunities. In this paper we develop an idea for describing, measuring and managing an enterprise’s ability to succeed in business networks: the concept of networkability. We illustrate the design objects of networkability using an example from the logistics industry and apply coordination theory to derive mechanisms which help to strengthen a company’s networkability. I. BUSINESS NETWORKING In the information age, the networking of companies is one of the most important business trends [17]. The many factors contributing to this trend include the diffusion of the Internet in the business world, the increasing availability of standards for information systems and data, the global competition in many branches of industry and the appearance of new types of companies, such as mega-mergers (e.g. DaimlerChrysler, MCI/Worldcom, Deutsche Bank/Bankers Trust) and start-up companies (e.g. Amazon.com, eBay, eToys, Yahoo! ). Within this context, maximum process efficiency and a continuous search for new fields of business are key success factors. This is the starting point of business networking, a concept we refer to as the design and management of IT-supported relationships with internal and external business partners. An example of how to profit from the advantages of increased efficiency and from new business segments is Riverwood International, a manufacturer of cardboard packaging in Atlanta, USA. Since two years, Riverwood has been pursuing a business networking strategy in the area of supply chain management, a strategy which aims at improving information exchange with customers (e.g. Anheuser-Busch, Miller Breweries, Coca-Cola). By using a supply chain management system (SAP APO), the current sales plans of the customers were directly linked to Riverwood’s production planning. The consequences of business networking were a reduction in stock levels and increased flexibility. With this as a basis, Riverwood is planning to offer a new service which will be responsible for the exchange of planning data for the whole paper-processing industry in the USA. As Fig. 1 shows, this supply chain center uses different electronic services (eServices) and standards (business bus). Beschaffung Small Customer 2
The Embodiment of Emotion

In current psychological discourse, it is fashionable to talk about emotions as “embodied” phenomena. At first glance, this idea is not novel. Historically, almost all psychological theories of emotion have proposed that emotional reactions are constituted by the body in some fashion. Some suggest that changes in the body cause changes in the mind; others suggest the opposite, or that the body and mind interact to produce an emotional response. Amid theoretical differences, these theories use the common metaphor that the body and mind are separate and independent forces that can act upon one another in an emotional episode. Current embodiment theories of the mind challenge this assumption by suggesting that the body helps to constitute the mind in shaping an emotional response. This view has novel implications for understanding the structure and content of the conceptual system for emotion, as well as for defining what emotions are and how they are caused. In the present chapter, we explore a more modern embodiment view of emotion. First, we discuss how the Cartesian “machine metaphor” underlies much theorizing about emotion, as we situate an embodied view of emotion in its historical context. Our historical review is not intended to be comprehensive but rather to illustrate how emotion theories to date have conceptualized the role of the body and mind in emotion.
A Wideband Class-AB Power Amplifier With 29–57-GHz AM–PM Compensation in 0.9-V 28-nm Bulk CMOS

A wideband amplitude to phase (AM–PM) compensated class-AB power amplifier (PA) suitable for highly integrated fifth-generation phased arrays is designed in 0.9-V 28-nm CMOS without RF ultra-thick top metal. Design techniques to realize broadband impedance transformation, power division/combining, and phase distortion linearization are discussed. Further, second-order effects due to practical layout constrains imposed by deep-scaled technologies are addressed and simple design solutions are proposed. The designed PA shows a measured <inline-formula> <tex-math notation="LaTeX">$S_{21} -3$ </tex-math></inline-formula> dB bandwidth (BW) from 29 to 57 GHz (65%) with <inline-formula> <tex-math notation="LaTeX">$|\text {AM}-\text {PM}|<1 {^{\circ }}$ </tex-math></inline-formula> up to <inline-formula> <tex-math notation="LaTeX">$P_{1~\text {dB}}$ </tex-math></inline-formula>. The measured <inline-formula> <tex-math notation="LaTeX">$P_{\mathrm{ sat}}$ </tex-math></inline-formula> is 15.1 dBm over >56% <inline-formula> <tex-math notation="LaTeX">$\text {BW}_{-1~\text {dB}}$ </tex-math></inline-formula>, with a peak power added efficiency of 24.2%. When a signal with wide modulation BW is applied, the realized PA enables up to 10.1-, 8.9-, and 5.9-dBm average <inline-formula> <tex-math notation="LaTeX">$P_{\mathrm{ OUT}}$ </tex-math></inline-formula> while amplifying a 1.5-, 3-, and 6-Gb/s 64-quadratic-amplitude modulation, respectively, at 34 GHz. The in-band and out-of-band linearity measured in error vector magnitude and adjacent channel power ratio are always better than −25 dB and −30 dBc, respectively, without any digital pre-distortion.
Lophirones B and C halt acetaminophen hepatotoxicity by upregulating redox transcription factor Nrf‐2 through Akt, PI3K, and PKC pathways

We investigated the mechanism of lophirones B‐ and C‐mediated protection against acetaminophen hepatotoxicity. Mice were pretreated with 20 mg/kg body weight lophirones B and C for 7 days and challenged with acetaminophen on day 7. Acetaminophen raised nuclear factor‐κB (NF‐κB) in the liver of mice but lowered protein kinase B (Akt). Although, acetaminophen produced no significant alteration on nuclear erythroid related factor‐2 (Nrf‐2), phosphoinositide 3‐kinase (PI3K) and protein kinase C (PKC), lophirones B and C raised the level of these proteins and Akt. The acetaminophen‐mediated increase in NF‐κB was significantly reversed by lophirones B and C. Lophirones B and C prevented acetaminophen‐mediated alterations in serum biomarkers of hepatic injury. Similarly, lophirones B and C lowered the biomarkers of oxidative stress in the liver of acetaminophen‐treated mice. It can be inferred from this study that lophirones B and C prevent acetaminophen‐induced liver injury by enhancing Nrf‐2 through Akt, PI3K, and PKC pathways.
Bering Sea Expedition Summary : Pliocene-Pleistocene Evolution and Glacial-Interglacial Changes in the Bering Sea

Over the last 5 million years (m.y.), global climate has evolved from being warm with only small Northern Hemisphere glaciers and ice sheets (~5-3 Ma) to being cold with major Northern Hemisphere glaciations occurring every 100 to 40 thousand years (k.y.). The reasons for this major transition are unknown. Although there are data to show that the Pacific experienced oceanographic reorganizations that were just as dramatic as those in the Atlantic, the scarcity of data in critical regions of the Pacific (the largest ocean with arguably the largest potential to influence global climate) has prevented an evaluation of the role of North Pacific processes in global climate evolution.
Anxiety symptoms in regular school students in Mumbai City, India

Aim: Anxiety disorders usually remain undiagnosed in school students owing to the internalized nature of their symptoms. The present study was conducted with the primary objective of evaluating the prevalence of anxiety symptoms in school students in Mumbai. A secondary objective was to assess the impact of variables (age, gender, presence of sibling, and type of school curriculum or school) on anxiety symptoms. Materials and Methods: Study cases (8–15 year olds) were recruited by nonprobability sampling from four English-medium schools. Anxiety was measured using Spence Children's Anxiety Scale (SCAS)-child self-report questionnaire. T-scores (total and subscales) were calculated and cut-off scores of >60 were considered as significant. Results: Symptoms of overall anxiety were present in 10.8% (53/493) of the students. Older students (12–15 year olds) had greater odds of having overall anxiety symptoms (crude OR = 4.36, 95% CI 2.27 to 8.39, P < 0.0001). Symptoms of all anxiety disorders were present in the 493 participants, with obsessions/compulsions and fears of physical injury being the most common (in 29.6% and 27.2%, respectively). Older students and boys had greater odds of having obsessions/compulsions (crude OR = 2.32, 95% CI 1.56 to 3.44, P < 0.0001; and crude OR = 1.54, 95% CI 1.04 to 2.27, P= 0.035, respectively]. Students with sibling (s) had greater odds of having fears of physical injury (crude OR = 0.48, 95% CI 0.30 to 0.78, P= 0.003). Conclusions: There is an urgent need to screen school students in our city for anxiety disorders.
Intra- and Inter-Frequency Brain Network Structure in Health and Schizophrenia

Empirical studies over the past two decades have provided support for the hypothesis that schizophrenia is characterized by altered connectivity patterns in functional brain networks. These alterations have been proposed as genetically mediated diagnostic biomarkers and are thought to underlie altered cognitive functions such as working memory. However, the nature of this dysconnectivity remains far from understood. In this study, we perform an extensive analysis of functional connectivity patterns extracted from MEG data in 14 subjects with schizophrenia and 14 healthy controls during a 2-back working memory task. We investigate uni-, bi- and multivariate properties of sensor time series by computing wavelet entropy of and correlation between time series, and by constructing binary networks of functional connectivity both within and between classical frequency bands (, , , and ). Networks are based on the mutual information between wavelet time series, and estimated for each trial window separately, enabling us to consider both network topology and network dynamics. We observed significant decreases in time series entropy and significant increases in functional connectivity in the schizophrenia group in comparison to the healthy controls and identified an inverse relationship between these measures across both subjects and sensors that varied over frequency bands and was more pronounced in controls than in patients. The topological organization of connectivity was altered in schizophrenia specifically in high frequency and band networks as well as in the - cross-frequency networks. Network topology varied over trials to a greater extent in patients than in controls, suggesting disease-associated alterations in dynamic network properties of brain function. Our results identify signatures of aberrant neurophysiological behavior in schizophrenia across uni-, bi- and multivariate scales and lay the groundwork for further clinical studies that might lead to the discovery of new intermediate phenotypes.
Pediatric pulmonology year in review 2017: Part 4 (Sleep medicine)

Pediatric Pulmonology publishes original research, case reports and review articles on topics related to a wide range of children's respiratory disorders. In this article (Part 4 of a 5‐part series), we summarize the past year's publications in sleep medicine, in the context of selected literature in this area from other journals. Articles are highlighted on topics including diagnosis and treatment of OSAS, sleep duration and position, and sleep disorders in chronic disease.
Vocabulary Usage in Newswire Summaries

Analysis of 9000 manually written summaries of newswire stories used in four Document Understanding Conferences indicates that approximately 40% of their lexical items do not occur in the source document. A further comparison of different summaries of the same document shows agreement on 28% of their vocabulary. It can be argued that these relationships establish a performance ceiling for automated summarization systems which do not perform syntactic and semantic analysis on the source document.