Miracle-dz/UniFAR-FTUs huggingface dataset:
Accuracy of noninvasive, single-plane fluoroscopic analysis for measurement of three-dimensional femorotibial joint poses in dogs treated by tibial plateau leveling osteotomy.

OBJECTIVE To compare accuracy of a noninvasive single-plane fluoroscopic analysis technique with radiostereometric analysis (RSA) for determining 3-D femorotibial poses in a canine cadaver stifle joint treated by tibial-plateau-leveling osteotomy (TPLO). SAMPLE Left pelvic limb from a 25-kg adult mixed-breed dog. PROCEDURES A CT scan of the left pelvic limb was performed. The left cranial cruciate ligament was transected, and a TPLO was performed. Radiopaque beads were implanted into the left femur and tibia, and the CT scan was repeated. Orthogonal fluoroscopic images of the left stifle joint were acquired at 5 stifle joint flexion angles ranging from 110° to 150° to simulate a gait cycle; 5 gait cycles were completed. Joint poses were calculated from the biplanar images by use of a digitally modified RSA and were compared with measurements obtained by use of hybrid implant-bone models matched to lateral-view fluoroscopic images. Single-plane measurements were performed by 2 observers and repeated 3 times by the primary observer. RESULTS Mean absolute differences between results of the single-plane fluoroscopic analysis and modified RSA were 0.34, 1.05, and 0.48 mm for craniocaudal, proximodistal, and mediolateral translations, respectively, and 0.56°, 0.85°, and 1.08° for flexion-extension, abduction-adduction, and internal-external rotations, respectively. Intraobserver and interobserver mean SDs did not exceed 0.59 mm for all translations and 0.93° for all rotations. CONCLUSIONS AND CLINICAL RELEVANCE Results suggested that single-plane fluoroscopic analysis by use of hybrid implant-bone models may be a valid, noninvasive technique for accurately measuring 3-D femorotibial poses in dogs treated with TPLO.
Identification of the stumptailed macaque virus as a new papovavirus

A new viral agent, stumptailed macaque virus (STMV), isolated from uninoculated stumptailed macaque kidney cultures was identified. The virions had the size and morphology of papovaviruses of the simian virus 40 (SV40)-polyoma subgroup, but many of them appeared to have an additional outer envelope. The deoxyribonucleic acid of STMV was a superhelical circular molecule, with a mean length 91% of that of SV40. The antigenic relationship of this virus with other members of the group was examined by immune electron microscopy of isolated virions and by immunofluorescent staining of virus-infected cells. STMV was immunologically distinct from SV40, BK virus (BKV), polyoma virus, and JC virus. Its tumor antigen may be related to those of SV40 and BKV.
Association between Serum Selenium Concentrations and Levels of Proinflammatory and Profibrotic Cytokines—Interleukin-6 and Growth Differentiation Factor-15, in Patients with Alcoholic Liver Cirrhosis

According to some authors, serum selenium levels are strongly associated with the severity of liver diseases, including liver cirrhosis. The aim of this study was to determine the relationship between the concentration of selenium and pro-inflammatory and profibrotic cytokines—interleukin-6 (IL-6) and growth differentiation factor 15 (GDF-15) in patients with alcoholic liver cirrhosis. The parameters studied were determined in the serum of 99 patients with alcoholic liver cirrhosis divided based on the severity of disease according to the Child-Turcotte-Pugh criteria. In patients with liver cirrhosis, the serum selenium concentration was statistically lower, whereas serum IL-6 and GDF-15 concentrations were higher than those in the control group. Moreover, the concentration of selenium negatively correlated with the levels of GDF-15 and IL-6. The above results may indicate a role of selenium deficiency in the pathogenesis and progression of alcoholic liver disease.
Partial Wave Analysis of the Reaction γp → pω and the Search for Nucleon Resonances

An event-based partial wave analysis (PWA) of the reaction gamma p -> p omega has been performed on a high-statistics dataset obtained using the CLAS at Jefferson Lab for center-of-mass energies from threshold up to 2.4 GeV. This analysis benefits from access to the world's first high precision spin density matrix element measurements, available to the event-based PWA through the decay distribution of omega-> pi+ pi - pi0. The data confirm the dominance of the t-channel pi0 exchange amplitude in the forward direction. The dominant resonance contributions are consistent with the previously identified states F[15](1680) and D[13](1700) near threshold, as well as the G[17](2190) at higher energies. Suggestive evidence for the presence of a J(P)=5/2(+) state around 2 GeV, a "missing" state, has also been found. Evidence for other states is inconclusive.
miR-21 promotes the differentiation of hair follicle-derived neural crest stem cells into Schwann cells

Hair follicle-derived neural crest stem cells can be induced to differentiate into Schwann cells in vivo and in vitro. However, the underlying regulatory mechanism during cell differentiation remains poorly understood. This study isolated neural crest stem cells from human hair follicles and induced them to differentiate into Schwann cells. Quantitative RT-PCR showed that microRNA (miR)-21 expression was gradually increased during the differentiation of neural crest stem cells into Schwann cells. After transfection with the miR-21 agonist (agomir-21), the differentiation capacity of neural crest stem cells was enhanced. By contrast, after transfection with the miR-21 antagonist (antagomir-21), the differentiation capacity was attenuated. Further study results showed that SOX-2 was an effective target of miR-21. Without compromising SOX2 mRNA expression, miR-21 can down-regulate SOX protein expression by binding to the 3′-UTR of miR-21 mRNA. Knocking out the SOX2 gene from the neural crest stem cells significantly reversed the antagomir-21 inhibition of neural crest stem cells differentiating into Schwann cells. The results suggest that miR-21 expression was increased during the differentiation of neural crest stem cells into Schwann cells and miR-21 promoted the differentiation through down-regulating SOX protein expression by binding to the 3′-UTR of SOX2 mRNA.
Origins and levels of post pasteurization contamination of milk in the dairy and their effects on keeping quality

Summary Bacterial post pasteurization contamination with psychrotrophic Gram-negative rods (GNR) was measured in commercial milks before and after transfer to retail containers. The tanks of pasteurized milk feeding the filling units contaminated milk less often (39% of samples) but usually at a higher level than the filling units (92% of samples). The number of GNR present had a considerable influence on the shelf life of milk, and the range found in commercially pasteurized milk was reflected in a wide range of shelf lives.
Effects of dietary glycemic index on brain regions related to reward and craving in men

A selection of abstracts of clinically relevant papers from other journals. The abstracts on this page have been chosen and edited by John R. Radford. Following consumption of the high GI test meal, there was increased activity in the right nucleus accumbens, that area of the brain associated with reward and craving.
Extraction of Heart Rate Parameters Using Speech Analysis

: The heart rate variation has been observed when analyzing the speech analysis of a person sitting at remote place. In the presented approach, 20 –30 years age group person’s speech is recorded using the common recording utility for testing purposes. The time duration for speech production is approximately 1 - 2 minutes. Further, the entropy, energy, power, mean, frequency, standard deviation and variance are computed by statistical analysis of the speech signal. The equations for the same are illustrated in algorithm section of the paper. A correlation is established between the heart rate and features of the speech signal. The validation of the algorithm for correlation between the features and heart rate is the important activity of the work. More and more no. of speech signal samples may be tried out for exact correlation of heart rate and feature vectors.
Porphyromonas gingivalis Gingipains and Adhesion to Epithelial Cells

ABSTRACT Porphyromonas gingivalis is one of the principal organisms associated with adult periodontitis. Bacterial surface proteins such as fimbriae and gingipain hemagglutinin domains have been implicated as adhesins that actuate colonization of epithelium lining the gingival sulcus. We investigated the genetics of P. gingivalis adhesion to monolayers of epithelial cells using wild-type and gingipain mutant strains. These experiments suggested that arginine-specific gingipain (Rgp) catalytic activity modulated adhesion. From the data obtained with rgp mutants, we constructed a working hypothesis predicting that attachment and detachment of P. gingivalis to epithelial cells were mediated by gingipain adhesin and Rgp catalytic domains, respectively. A membrane-based epithelial cell binding assay, used to locate adhesins in extracellular fractions of wild-type and mutant strains, recognized gingipain peptides as adhesins rather than fimbriae. We developed a capture assay that demonstrated the binding of gingipain adhesin peptides to oral epithelial cells. The adherence of fimbrillin to epithelial cells was detected after heat denaturation of cell fractions. The prediction that Rgp catalytic activities mediated detachment was substantiated when the high level of attachment of anrgp mutant was reduced in the presence of wild-type cell fractions that contained gingipain catalytic activities.
Evaluating the Relationship among Clinical Measures of Working Memory

Working memory is a construct that has received considerable attention and undergone significant theoretical evolution in the past 35 years. Nevertheless, agreement upon a definition of the concept has not occurred. Contributing to this disagreement are the many ways the concept is operational ized, as is evidenced across various standardized tests that purport to measure working memory. The present study examined this relationship among the working memory component of popular cognitive tests, including the Wechsler Adult Intell igence Scale­ Third Edition, Wechsler Memory Scale Third Edition, Stanford-Binet Intell igence Scale Fifth Edition, and the Wide Range Assessment ofMemory and Learning Second Edition. To evaluate this, 66 normal participants were administered eight individual subtests from the four measures. Results indicated significant, yet moderate, correlations between all subtests and indexes, and repeated measures analysis of variance indicated significant differences between some subtests. Impl ications are discussed, including the relevance to the clinical assessment of working memory. Evaluating Relationships tv
Selective therapeutic control of C5a and the terminal complement complex by anti-C5 single-chain Fv in an experimental model of antigen-induced arthritis in rats.

OBJECTIVE To determine the role of the terminal complement complex (TCC) in the development of experimental antigen-induced arthritis (AIA) and the therapeutic effects of human anti-C5 single-chain Fv (scFv). METHODS Two different anti-C5 scFv, one that inhibits both release of C5a and assembly of the TCC (TS-A 12/22) and another that selectively blocks formation of the TCC (TS-A 8), were injected at the onset of AIA. The effects of these scFv on disease severity were evaluated for up to 21 days and compared with the effects of injection of an unrelated scFv. AIA was also established in C6-deficient and C6-sufficient PVG rats to obtain further information on the role of the TCC in this model. RESULTS TS-A 12/22 and TS-A 8 proved to be equally effective in reducing joint swelling, cell counts and tumor necrosis factor alpha levels in synovial lavage fluids, and the degree of histomorphologic changes compared with the effects of the unrelated scFv. TS-A 12/22 and TS-A 8 prevented the deposition of C9 but not that of C3, confirming the ability of the 2 scFv to neutralize C5. Administration of the 2 anti-C5 scFv after AIA onset also reduced disease severity. In C6-deficient rats with AIA, disease activity was reduced markedly compared with that in C6-sufficient rats. CONCLUSION These 2 human anti-C5 scFv could represent potential therapeutic reagents to be used in patients with rheumatoid arthritis. In addition, the finding that TS-A 8 was as effective as TS-A 12/22 in reducing disease severity suggests that the TCC is mainly responsible for the joint inflammation and damage observed in AIA.
On the Revelation Principle and Reciprocal Mechanisms in Competing Mechanism Games

This paper provides a set of mechanisms that we refer to as emph{reciprocal mechanisms. }These mechanisms have the property that every outcome that can be supported as a Bayesian equilibrium in a competing mechanism game can be supported as an equilibrium in reciprocal mechanisms. In this sense, reciprocal mechanisms play the same role as direct mechanisms do in single principal problems. The advantage of these mechanisms over alternatives like the universal set of mechanisms is that they are conceptually straightforward and no more difficult to deal with than the simple direct mechanisms used in single principal mechanism design.
Theoretical and Experimental Studies on Bistability in Semiconductor Ring Lasers With Two Optical Injections

Bistability in a semiconductor ring laser with two external optical injections is studied theoretically, numerically, and experimentally. Two optical injections are added to the two counterpropagating modes in the laser respectively. We first predicted theoretically that, with one of them acting as a static holding beam, the intensities of both modes will form a hysteresis loop as a function of the intensity of the second injection due to nonlinear mode competition. The bistability and the hysteresis characteristics such as its width depend heavily on the intensity of the holding beam. Average switching power will increase as the intensity of the holding beam is increased, accompanied by shrinking width of the hysteresis loop. Numerical simulations and experiment are then carried out to verify the theoretical prediction, and the hysteresis loops at different holding beam strength are plotted. The numerical results together with the qualitative experimental results demonstrate what has been predicted by the theoretical analysis, and a good agreement is obtained. The interaction between the two injections demonstrates potentials for application in all-optical digital signal processing.
The Development of Treatment for Parkinson's Disease

Parkinson’s disease (PD) is a slowly progressive, age-related, second most common neurodegenerative disorder after Alzheimer’s disease of unknown etiology. Dopamine replacement therapies were introduced five decades ago and still remain the mainstay of treatment for Parkinson’s disease. However, with long-term treatment with L-dopa, more than 50% of patients were found to develop motor response complications approximately after 4 - 5 years of initiation of continuous treatment, in 80% of patients treated for 10 years, and in nearly 100% patients with young-onset disease. The complications of long–term treatment with levodopa include-motor fluctuations, dyskinesias, and nonmotor fluctuations are such as mood disturbance, cognitive dysfunction, dysautonomia and pain. Till date, there are various therapeutic approaches having been developed for the treatment of advanced PD comprising Pharmacotherapy, neurotrophic factors, surgical procedures such as DBS, cell-based therapies and gene therapies. The pharmacological and surgical therapies are only aiming to improve the symptoms of PD, but none are proven to have a significant effect on the underlying disease process with respect to either slowing disease progression or restoring the affected dopaminergic neurons. Although there is no cure for PD, Gene based therapy has significant prospective advantages over the conventional treatment modalities for PD, as it could theoretically be used to preserve or restore dopaminergic neurons affected by PD through the action of neurotrophic factors or alternatively increase the availability of enzymes required for dopamine synthesis. All commonly employed PD therapies focus on the amelioration of symptoms and do not cure disease. In this review only we summarize the newer therapeutic strategies for the treatment of PD such as anti-inflammatories, neurotrophic factors, neurosurgical procedures (DBS), cell based therapies and gene therapies.
A Nationwide Study on the Risk of Autism After Prenatal Stress Exposure to Maternal Bereavement

OBJECTIVE. Prenatal stress has been linked to several adverse neurobehavioral outcomes, which may share a common pathophysiology with autism. We aimed to examine whether prenatal stress exposure after maternal bereavement is associated with an increased risk of autism later in life. METHODS. We conducted a nationwide population-based cohort study of all 1492709 singletons in Denmark born from 1978 to 2003. A total of 37275 children were born to women who lost a close relative during pregnancy or up to 1 year before pregnancy. These children were included in the exposed group, and the remaining children were in the unexposed group. All children were followed up from birth until their death, migration, onset of autism, or the end of 2006. Information on autism was obtained from the Danish Psychiatric Central Register. We used Cox regression models to estimate hazard ratios in the exposed group compared with those in the unexposed group. RESULTS. Maternal bereavement during the prenatal period was not associated with an increased risk of autism in the offspring. The hazard ratios did not differ by the nature of the exposure (maternal relationship to the deceased or cause of death). The hazard ratios were comparable between the 5 prenatal exposure periods under study (7–12 months before pregnancy, 0–6 months before pregnancy, first trimester, second trimester, and third trimester). CONSLUSIONS. This is the first population-based cohort study to examine the effect of prenatal stress on autism in childhood. Our data do not support any strong association between prenatal stress after maternal bereavement and the risk of autism.
The power of prediction: cloud bandwidth and cost reduction

In this paper we present PACK (Predictive ACKs), a novel end-to-end Traffic Redundancy Elimination (TRE) system, designed for cloud computing customers. Cloud-based TRE needs to apply a judicious use of cloud resources so that the bandwidth cost reduction combined with the additional cost of TRE computation and storage would be optimized. PACK's main advantage is its capability of offloading the cloud-server TRE effort to end-clients, thus minimizing the processing costs induced by the TRE algorithm. Unlike previous solutions, PACK does not require the server to continuously maintain clients' status. This makes PACK very suitable for pervasive computation environments that combine client mobility and server migration to maintain cloud elasticity. PACK is based on a novel TRE technique, which allows the client to use newly received chunks to identify previously received chunk chains, which in turn can be used as reliable predictors to future transmitted chunks. We present a fully functional PACK implementation, transparent to all TCP-based applications and network devices. Finally, we analyze PACK benefits for cloud users, using traffic traces from various sources.
Effect of Genetic and Environmental Factors on Growth

Objectives: The purpose of this study is to estimate genetic and environmental factors which can effect growth, and predict final height using this factors. Methods: Correlation analysis and regression analysis were conducted between measurements of height and Genetic & environmental factors through survey from 1352 child & adolescent patients. Results: Factors which have correlation with height percentile are MPH(Mid-Parental Height), NBW(Neonatal body weight), anorexia, dyspepsia, atopic dermatitis, frequency of breakfast and quality of sleeping time. MPH has moderate relation, NBW and anorexia have fair relation, and other factors have linear but poor relation. Regression equation from factors which have correlation and height percentile has 26.9% of predictive power. Regression equation considering only genetic factor has 20.4%. MPH has the most effect on height percentile. Anorexia has more effect than NBW. Other factors also have small and similar effect. Conclusions: Height of parents has the most effect on growth, anorexia, dyspepsia, atopic dermatitis, frequency of breakfast and quality of sleeping time also has effect.
Olfactory biopsies demonstrate a defect in neuronal development in Rett's syndrome

Rett's Syndrome (RTT) is a neurodevelopmental disorder resulting from mutation in the mecp2 gene that encodes methyl CpG binding protein 2, a transcriptional repressor. Because this disease primarily affects neurons, tissue is not available during active disease. We used the olfactory system as a model to investigate abnormalities in neuronal development in RTT, because olfactory receptor neurons (ORNs) are replaced throughout life by ongoing postnatal neurogenesis. Thus, even in the adult, the olfactory epithelium contains neurons at various developmental stages. We obtained biopsies of nasal epithelium containing ORNs from RTT patients and age‐matched controls to study the status of the neuronal population using antibodies to stage‐specific developmental markers. There were no postprocedure complications. Compared with age‐matched controls, there were far fewer mature ORNs, as defined by olfactory marker protein expression, and significantly greater numbers of immature neuron‐specific tubulin–positive ORNs present. In RTT biopsies, olfactory marker protein–positive neurons displayed abnormal structure. These results suggest that dysfunction of MeCP2 results in decreased survival of mature ORNs with a compensatory increase in neurogenesis, or a failure of immature neurons to mature. Our study indicates that olfactory biopsies provide a method to study neuronal developmental diseases in adults and children. Ann Neurol 2003
ndividual differences in everyday retrospective memory failures

The present study examined individual differences in everyday retrospective memory failures. Undergraduate students completed various cognitive ability measures in the laboratory and recorded everyday retrospective memory failures in a diary over the course of a week. The majority of memory failures were forgetting information pertaining to exams and homework, forgetting names, and forgetting login and ID information. Using latent variable techniques the results also suggested that individual differences in