Miracle-dz/UniFAR-FTUs huggingface dataset:
Expression of killer cell inhibitory receptors is restricted to true NK cell lymphomas and a subset of intestinal enteropathy-type T cell lymphomas with a cytotoxic phenotype

Background/Aims—Killer inhibitory receptors (KIR) have a modulating effect on the cytotoxic functions of natural killer (NK) cells and T cells. Because lymphoma cells often have the same receptors as their non-neoplastic counterparts, this study investigated the expression of KIR on well defined groups of NK and T cell lymphomas, with and without a cytotoxic phenotype, from different sites of origin. Methods—Nine CD56+/CD3− NK cell lymphomas, 29 CD3+/CD56− T cell lymphomas with a cytotoxic phenotype, and 19 T cell lymphomas without a cytotoxic phenotype were stained for KIR using monoclonal antibodies specific for CD94, CD158a, and CD158b. In addition, the expression of KIR was studied on normal lymphoid tissues. Results—KIR expression was seen in five of nine true NK cell lymphomas including three of four nasal, one of four cutaneous, and one of one intestinal lymphoma nasal type. Double staining for CD56 and CD94 in normal lymphoid tissues revealed that KIR was predominantly expressed by CD56+ NK cells and sporadically on CD8+ T cells. Moreover, enteropathy-type T cell lymphomas with a cytotoxic phenotype showed KIR expression (three cases expressing CD94 and one case expressing CD158a). All nodal and extranodal non-intestinal T cell lymphomas with or without a cytotoxic phenotype lacked expression of KIR. Conclusions—These results show that KIR expression is restricted to CD56+/CD3− true NK cell lymphomas originating from the nose, gut, and skin, as well as in a subset of extranodal T cell lymphomas originating from the small intestine, which possessed a cytotoxic phenotype. Thus, the presence of KIR on NK/T cell lymphomas seems to mimic the distribution of KIR found on NK and T cells in normal lymphoid tissue.
Faster deterministic sorting and searching in linear space

We present a significant improvement on linear space deterministic sorting and searching. On a unit-cost RAM with word size w, an ordered set of n w-bit keys (viewed as binary strings or integers) can be maintained in O(min{[/spl radic/(logn)][logn/logw+loglogn][logwloglogn]}) time per operation, including insert, delete, member search, and neighbour search. The cost for searching is worst-case while the cost for updates is amortized. As an application, n keys can be sorted in linear at O(n/spl radic/(logn)) worst-case cost. The best previous method for deterministic sorting and searching in linear space has been the fusion trees which supports updates and queries in O(logn/loglogn) amortized time and sorting in O(nlogn/loglogn) worst-case time. We also make two minor observations on adapting our data structure to the input distribution and on the complexity of perfect hashing.
Arbitrarily varying networks: Capacity-achieving computationally efficient codes

We consider the problem of communication over a network containing a hidden and malicious adversary that can control a subset of network resources, and aims to disrupt communications. We focus on omniscient node-based adversary, i.e., the adversary can control a subset of nodes, and knows the message, network code and packets on all links. Characterizing information-theoretically optimal communication rates as a function of network parameters and bounds on the adversarially controlled network is in general open, even for unicast (single source, single destination) problems. In this work we characterize the information-theoretically optimal randomized capacity of such problems, i.e., under the assumption that the source node shares (an asymptotically negligible amount of) independent common randomness with each network node a priori. We propose a novel computationally-efficient communication scheme whose rate matches a natural information-theoretically “erasure outer bound” on the optimal rate. Our schemes require no prior knowledge of network topology, and can be implemented in a distributed manner as an overlay on top of classical distributed linear network coding.
Lipschitz condition for finding real roots of a vector function

Computing real roots of a continuous function is an old and extensively researched problem in numerical computation. Exclusion algorithms have been used recently to find all solutions of a system of nonlinear equations or to find the global minimum of a function over a compact domain. These algorithms are based on a root condition that can be applied to each cell in the domain. In the present paper, we consider Lipschitz functions of order α and give the root condition for the exclusion algorithms. Furthermore, we investigate convergence and computational complexity for such algorithms and illustrate their performance by a numerical example.
Fenoterol stimulates human erythropoietin production via activation of the renin angiotensin system.

AIMS The present study assessed the hypothesis that the beta2 sympathomimetic fenoterol influences the production of erythropoietin (EPO) by activation of the renin angiotensin system (RAS), i.e. angiotensin II. METHODS In an open, parallel, randomized study healthy volunteers received i.v. either placebo (electrolyte solution), fenoterol or fenoterol in combination with an oral dose of the AT1-receptor antagonist losartan. RESULTS Compared with placebo treatment AUCEPO(0,24 h) was significantly increased after fenoterol application by 48% whereas no increase in the group receiving fenoterol and losartan could be detected. The rise of PRA was statistically significant under fenoterol and fenoterol plus lorsartan. CONCLUSIONS Stimulation of EPO production during fenoterol infusion appears to be angiotensin II-mediated. Thus, angiotensin II may be considered as one important physiological modulator of EPO production in humans.
Intra‐articular Adjuvant Analgesics following Knee Arthroscopy: Comparison between Single and Double Dose Dexmedetomidine and Ropivacaine A Multicenter Prospective Double‐blind Trial

Knee arthroscopy is a commonly performed orthopedic procedure. Post‐operatively, adequate pain relief reduces the surgical stress response and patient's morbidity and facilitates rehabilitation. The analgesic effect of dexmedetomidine (2 μg/kg body weight) as an adjunct to ropivacaine in knee arthroscopic knee procedures was studied to determine whether this would achieve longer post‐operative analgesia and whether the study dosage of dexmedetomidine was safe and free of adverse effects.
Nicotiana benthamiana gp91phox Homologs NbrbohA and NbrbohB Participate in H2O2 Accumulation and Resistance to Phytophthora infestans Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.008680.

Active oxygen species (AOS) are responsible for triggering defense responses in plants. Respiratory burst oxidase homologs (rboh genes) have been implicated in AOS generation. We have isolated two rboh cDNAs, NbrbohA and NbrbohB, from Nicotiana benthamiana leaves. NbrbohA was expressed constitutively at a low level and the transcripts were increased after mechanical stress of control leaf infiltration, whereas NbrbohB was induced specifically by the protein elicitor INF1 from the potato pathogen Phytophthora infestans. We examined the function of the Nbrboh genes in AOS generation and in the hypersensitive response (HR) using virus-induced gene silencing (VIGS). VIGS indicated that both genes are required for H2O2 accumulation and for resistance to Phytophthora. VIGS of Nbrboh genes also led to a reduction and delay of HR cell death caused by INF1. We further demonstrate that the induction of HR-like cell death by overexpression of a constitutively active mutant of a mitogen-activated protein kinase kinase, MEKDD, is compromised by VIGS of NbrbohB. We found that MEKDD induced NbrbohB but not NbrbohA. This work provides genetic evidence for the involvement of a mitogen-activated protein kinase cascade in the regulation of rboh genes.
Monitoring reproductive aging in a 5-year prospective study: aggregate and individual changes in steroid hormones and menstrual cycle lengths with age

Objective: We describe a 5-year prospective study of reproductive aging, and present analyses of steroid hormone and menstrual cycle changes with age. Design: Participants were college-educated white women, primarily of northern European ancestry, recruited from the Tremin Research Program on Women's Health (n = 156, 25-58 years). In each of 5 consecutive years, they collected daily urine specimens for 6 months and recorded menstrual bleeds for all months. Urine specimens were assayed for estrone-3-glucuronide (E1G) and pregnanediol-3-glucuronide (PDG), urinary metabolites of estradiol and progesterone. Using multilevel models, we estimated hormone and cycle-length trajectories for individual women and within- and between-woman variance by age. Results: At the aggregate level, PDG declined beginning in the 30s, E1G increased into the 40s before declining, and cycle length became more variable with age. Individual-level models revealed substantial hormonal variation across women, in both absolute levels and rates of change. Most women showed declining E1G by the late 40s, declining PDG in the 30s, and increasing mean cycle length in the 40s. Hormonal variation decreased with age; cycle length variation decreased and then increased. Within individual women, cycle lengths were highly variable while hormone levels were more stable. Women differed more from each other in hormone levels than for cycle lengths. Conclusions: Aggregate-level analyses show general changes in steroid hormones and cycle length but cannot show variation within and across women. Individuals' cycle lengths were too variable to predict hormone levels. Clinicians should obtain more data on individual women's hormonal patterns when determining fertility or menopause treatments.
Cross-Network Opportunistic Collection of Urgent Data in Wireless Sensor Networks

Ubiquitous smart environments equipped with low-cost and easily-deployable wireless sensor networks (WSNs) and ever-increasing widespread Mobile Ad hoc NETworks (MANETs) are opening brand new opportunities in environmental monitoring. This paper proposes an original solution for WSN/MANET integration based on the primary design guideline of opportunistically exploiting MANET overlays impromptu formed over the WSN to improve and boost the data collection task of a typical WSN. On the one hand, we adopt a cross-layer approach that exploits MANET connections to differentiate and fasten the delivery of sensed urgent data by pushing them over low-latency MANET paths. On the other hand, we take advantage of local cross-layer visibility of the WSN data collection procedures and protocols to carefully control and limit WSN–MANET coordination overhead. We claim that our proposed solution can obtain significant quality of service improvements via differentiation, by granting faster delivery times to urgent data with a very limited cost in most common execution scenarios.
Neopterin predicts cardiac dysfunction following cardiac surgery.

OBJECTIVES Oxidative stress following ischaemia and reperfusion, as well as inflammation, are thought to be important for the development of cardiac dysfunction after cardiac surgery. Our main objective was to investigate whether the inflammatory biomarkers C-reactive protein (CRP), lactoferrin, neopterin and the terminal complement complex (TCC) were associated with cardiac dysfunction after cardiac surgery. Another objective was to assess whether the biomarkers could improve prediction of postoperative cardiac dysfunction compared with clinical variables only. METHODS Blood samples and clinical data from 1018 consecutive patients undergoing cardiac surgery from 1 April 2008 to 19 April 2010 at St. Olavs University Hospital, Trondheim, Norway, were collected prospectively. The end-point was postoperative cardiac dysfunction, defined as the need for more than one inotropic agent or an intra-aortic balloon pump occurring after the operation and until the patient was discharged from the department. CRP, lactoferrin, neopterin and TCC were analysed in plasma, and we used logistic regression to evaluate the association of the biomarkers with postoperative cardiac dysfunction. We adjusted for the following clinical variables previously associated with postoperative cardiac dysfunction: urgent operation, operation type, previous cardiac surgery, chronic heart failure, pulmonary hypertension, previous myocardial infarction and haemoglobin. The likelihood ratio test, the integrated discrimination improvement and receiver operating characteristic (ROC) curves were used to assess whether the biomarkers could improve prediction of postoperative cardiac dysfunction compared with clinical variables alone. RESULTS Neopterin was the only biomarker significantly associated with postoperative cardiac dysfunction (odds ratio 2.73, 95% confidence interval 1.65-4.51) after adjustment for clinical variables. Neopterin improved risk prediction of cardiac dysfunction following heart surgery compared with clinical variables alone according to the likelihood ratio test (P < 0.0001) and the integrated discrimination improvement (P = 0.02), particularly for patients with intermediate risks. CONCLUSIONS Neopterin was associated with cardiac dysfunction following cardiac surgery, and improved the accuracy of risk prediction of postoperative cardiac dysfunction. At present, we do not suggest that neopterin should be measured routinely before heart surgery, but our findings support the hypothesis of the role of oxidative stress and inflammation in development of cardiac dysfunction following heart surgery.
Source-Channel Coding Under Energy, Delay, and Buffer Constraints

Source and channel coding for an energy-limited wireless sensor node is investigated. The sensor node observes independent Gaussian source samples with variances changing over time slots. The channel is modeled as a flat fading channel, whose gain remains constant during each time slot, and changes from one time slot to the next. The compressed samples are stored in a finite data buffer, and need to be delivered to the destination in at most d time slots. The objective is to minimize the average squared-error distortion between the source samples and their reconstructions. First, a battery operated system, in which the sensor node has a finite amount of energy at the beginning of transmission, is investigated. Then, the impact of energy harvesting, and the energy cost of processing and sampling are considered. The optimal compression and transmission policy is formulated as the solution of a convex optimization problem, and the properties of the optimal policies are identified. For the strict delay case, d=1, a two-dimensional (2D) waterfilling interpretation is provided. Numerical results are presented to illustrate the structure of the optimal policy, and to analyze the effect of the delay constraints, data buffer size, energy harvesting, and processing and sampling costs.
Frequency of visceral leishmaniasis in Abbottabad from 2005 to 2009.

BACKGROUND Leishmaniasis is a parasitic disease caused by a haemoflagellate Leishmania, transmitted to humans through bites of female sand fly. The objective of this study was to assess the frequency of leishmaniasis in Abbottabad and nearby areas including villages of Nawanshehr, Dhodial, Gamavan, Sheikhulbandi, Kakul and Malikpura. METHOD This was a retrospective study carried out in Pathology Department, Women Medical College and Benazir Bhutto Teaching Hospital Abbottabad from 2005 to 2009. The diagnosis was based on intracellular and extracellular amastigote forms of Leishmania donovani in the bone marrow aspirates. RESULTS We diagnosed 61 cases of visceral leishmaniasis, mostly from Nawanshehr (32.78%), in children below 5 years of age with febrile splenomegaly. CONCLUSION The disease is gradually spreading southwards in the country. A high index of suspicion should be kept in mind for all cases coming from Northern Areas of the country where the frequency is quite high. Local health authorities should take drastic action against this spreading disease.
The Mental Readiness Form as a Measure of Competitive State Anxiety

Two studies were designed to test the validity of the Mental Readiness Form (MRF; Murphy, Greenspan, Jowdy, and Tammen, 1989) with collegiate athletes. In Study 1, male and female athletes completed the CSAI-2 and the original or a modified MRF within 60 minutes prior to competition. In Study 2, subjects completed two forms of the MRF with slightly different anchor terms, the CSAI-2, trait anxiety measures, and a social desirability scale. Overall, results indicated moderate to strong correlations between corresponding CSAI-2 subscales and MRF items, supporting its concurrent validity. The intercorrelations among MRF items were high, but were similar to the intercorrelations among CSAI-2 subscales. Correlations with trait anxiety also supported the concurrent validity of the MRF. None of the MRF scales or the CSAI-2 were significantly correlated with social desirability. The preliminary analyses in these studies provide initial support for the MRF as a measure of competitive anxiety when expediency is an .
WSL: Sentence Similarity Using Semantic Distance Between Words

A typical social networking service contains huge amounts of data, and analyzing this data at the level of the sentence is important. In this paper, we describe our system for a SemEval2015 semantic textual similarity task (task2). We present our approach, which uses edit distance to consider word order, and introduce word appearance in context. We report the results from SemEval2015.
A tale of two parks: Tibetan youths’ preferences for tourism community futures

This study explores young hosts’ identification of tourism resources and their perceptions of different tourism site management styles in a suburban village in Lhasa, Tibet. Two tourism parks with different management styles co-exist in the same village. One is collectively owned and managed by the community and the other is developed and managed by an outside company. Compared with previous tourism community research, this empirical study has four notable features: it focuses on a non-Western, emerging tourism community; compares responses to two different development approaches within a community; targets the emic views of the young local citizens; and connects the present with the future. A combination of research methods, including key informant interviews, photo-elicitation interviews, and a questionnaire-based survey were used in sequence. The study suggests that the Tibetan young hosts have clear views about tourism, the future, and their local resources. They strongly preferred the community-based style for the future, and their preferences extended to the kinds of tourists who visited the community-based property. The study adds empirical weight to the voices of those researchers who call for strong community control over local tourism resources as well as suggesting the benefits this approach may deliver.
ON THE OBJECT-WISE TENSOR PRODUCT OF FUNCTORS TO MODULES

We investigate preserving of projectivity and injectivity by the object-wise tensor product of RC-modules, where C is a small category. In particular, let O(G,X) be the category of canonical orbits of a discrete group G, over a G-set X. We show that projectivity of RO(G,X)-modules is preserved by this tensor product. Moreover, if G is a finite group, X a finite G-set and R is an integral domain then such a tensor product of two injective RO(G,X)-modules is again injective.
Detection of jun but not fos protein during developmental cell death in sympathetic neurons

A large proportion of neurons die during normal development of the nervous system via an active process known as apoptosis. We counted the total number of neurons and apoptotic neurons in the superior cervical ganglion of the GH Wistar rat strain, which possesses a neurotrophic deficit leading to excessive perinatal cell death, and in its normal counterpart (N) by using the optical disector method to quantify the extent of apoptosis during postnatal development. Total neuron numbers fell between postnatal days 3 and 14 by 10 and 40% in N and GH, respectively. In GH ganglia, 1.5% of neurons were apoptotic at any given time, as determined by the presence of condensed chromatin clumps. Some types of cell death have been associated with expression of the immediate‐early genes c‐fos and c‐jun. Therefore, we used histological and immunocytochemical techniques to characterise individual neurons and to detect the products of these immediate‐early genes during developmental cell death. All apoptotic cells were immunopositive for c‐jun protein, whereas no c‐jun protein was detected in nonapoptotic cells. Conversely, members of the fos family of transcription factors were detected in the nucleus of 60% of nonapoptotic cells but in only a minor proportion of cells undergoing apoptosis. These results indicate that c‐jun occurs in neurons that are committed to die. This is the first situation in which the presence of jun protein has been correlated with normal programmed cell death in individual apoptotic neurons. © 1996 Wiley‐Liss, Inc.
Process-centered review of object oriented software development methodologies

We provide a detailed review of existing object-oriented software development methodologies, focusing on their development processes. The review aims at laying bare their core philosophies, processes, and internal activities. This is done by using a process-centered template for summarizing the methodologies, highlighting the activities prescribed in the methodology while describing the modeling languages used (mainly diagrams and tables) as secondary to the activities. The descriptions produced using this template aim not to offer a critique on the methodologies and processes, but instead provide an abstract and structured description in a way that facilitates their elaborate analysis for the purposes of improving understanding, and making it easier to tailor, select, and evaluate the processes.
From my perspective – Perceived participation in mainstream schools in students with autism spectrum conditions

Objectives: To examine perceived participation in students with ASC and their classmates in mainstream schools and to investigate correlations between activities the students wanted to do and actually participated in. Methods: Twenty-two students with ASC and their 382 classmates responded to a 46-item questionnaire regarding perceived participation in mainstream schools. Results: On 57% of the items, students with ASC perceived lower participation than their classmates. These results emphasize the importance of knowledge about students’ perceived participation. However, positive correlations between what the students wanted to do and actually did indicate that students with ASC may be participating to the extent that they wanted. Conclusion: Students with ASC perceived lower overall participation in mainstream school than their classmates. The correlations between “I want to” and “I do” statements in students with ASC indicated that aspects of autonomy are important to incorporate when studying, and interpreting, self-rated participation in mainstream schools.