Miracle-dz/UniFAR-FTUs huggingface dataset:
Induced sputum and bronchoscopy in the diagnosis of pulmonary tuberculosis

Background: Previous studies suggest that bronchoscopy and a single induced sputum sample are equally effective for diagnosing pulmonary tuberculosis. Methods: In a prospective study of subjects with possibly active pulmonary tuberculosis, the diagnostic yield of three induced sputum tests was compared with that of bronchoscopy. Subjects either produced no sputum or (acid fast) smear negative sputum. Bronchoscopy was only performed if at least two induced sputum samples were smear negative. Results: Of 129 subjects who completed all tests, 27 (21%) had smear negative and culture positive specimens, 14 (52%) on bronchoscopy and 26 (96%) on induced sputum (p<0.005). One patient was culture positive on bronchoscopy alone compared with 13 on induced sputum alone; 13 were culture positive on both tests. Induced sputum positivity was strikingly more prevalent when chest radiographic appearances showed any features of active tuberculosis (20/63, 32%) than when appearances suggested inactivity (1/44, 2%; p<0.005). Induced sputum costs were about one third those of bronchoscopy, and the ratio of costs of the two tests per case of tuberculosis diagnosed could be as much as 1:6. Conclusions: In subjects investigated for possibly active or inactive tuberculosis who produce no sputum or have smear negative sputum, the most cost effective strategy is to perform three induced sputum tests without bronchoscopy. Induced sputum testing carries a high risk of nosocomial tuberculosis unless performed in respiratory isolation conditions. The cost benefits shown could be lost if risk management measures are not observed.
‘Behind the doors of learning’: The transmission of racist and sexist discourses in a History classroom

Now that the doors of historically white schools have officially been opened to Black learners, this paper presents a critical analysis of discourses of domination transmitted behind the doors of learning in a History classroom. While the official History curriculum (NCS, 2002) advocates multi-perspectival epistemological approaches, this paper illustrates the subordination of epistemic goals to racist and sexist ideological goals through the transmission of racist and sexist discourses. A teacher’s lessons were observed, audio-taped, transcribed and analysed according to critical discourse theory. The conventional Grade 10 topic, The conquest of the Aztecs by the Spanish, was mediated through racist and sexist formal and informal discursive strategies such as the use of teacher power to silence contestation of inaccurate statements; the use of metaphor, simile, and binary oppositions to convey prejudicial meanings, derogation, inferiorisation, ridicule, jokes, disclaimers, and stereotyping that subsumed the historical topic being taught. The analysis exposes the informal yet effective workings of power for the perpetuation of discourses of domination in the History lesson. Such discourses subjected learners to a form of symbolic violence which may lead students to ontological misrecognition of self and race.
Dual-Differential Rheological Actuator for High-Performance Physical Robotic Interaction

Today's robotic systems are mostly rigid and position-controlled machines designed to operate in structured environments. To extend their application domains to partially unknown, dynamic, or anthropic environments, improved physical-interaction capabilities are required. In this new context, to blend the requirements for safety, robustness, and versatility is often a challenge, in part, because commonly available actuator technologies are inadequate. This paper presents our solution with the introduction of the dual-differential rheological actuator (DDRA) concept, which is based on the synergistic combination of an electromagnetic (EM) motor and two differentially coupled magnetorheological (MR) brakes. This paper describes the approach and the prototype design. It then discusses performances in force, motion, and interaction control.
User-calibration-free gaze tracking with estimation of the horizontal angles between the visual and the optical axes of both eyes

This paper presents a user-calibration-free method for estimating the point of gaze (POG) on a display accurately with estimation of the horizontal angles between the visual and the optical axes of both eyes. By using one pair of cameras and two light sources, the optical axis of the eye can be estimated. This estimation is carried out by using a spherical model of the cornea. The point of intersection of the optical axis of the eye with the display is termed POA. By detecting the POAs of both the eyes, the POG is approximately estimated as the midpoint of the line joining the POAs of both the eyes on the basis of the binocular eye model; therefore, we can estimate the horizontal angles between the visual and the optical axes of both the eyes without requiring user calibration. We have developed a prototype system based on this method using a 19" display with two pairs of stereo cameras. We evaluated the system experimentally with 20 subjects who were at a distance of 600 mm from the display. The result shows that the average of the root-mean-square error (RMSE) of measurement of POG in the display screen coordinate system is 16.55 mm (equivalent to less than 1.58°).
Mouse p53-Deficient Cancer Models as Platforms for Obtaining Genomic Predictors of Human Cancer Clinical Outcomes

Mutations in the TP53 gene are very common in human cancers, and are associated with poor clinical outcome. Transgenic mouse models lacking the Trp53 gene or that express mutant Trp53 transgenes produce tumours with malignant features in many organs. We previously showed the transcriptome of a p53-deficient mouse skin carcinoma model to be similar to those of human cancers with TP53 mutations and associated with poor clinical outcomes. This report shows that much of the 682-gene signature of this murine skin carcinoma transcriptome is also present in breast and lung cancer mouse models in which p53 is inhibited. Further, we report validated gene-expression-based tests for predicting the clinical outcome of human breast and lung adenocarcinoma. It was found that human patients with cancer could be stratified based on the similarity of their transcriptome with the mouse skin carcinoma 682-gene signature. The results also provide new targets for the treatment of p53-defective tumours.
The Rise and Fall of a Statewide Assessment System

Details the history of California’s experience with large-scale writing assessment. Describes the introduction, development, and scoring of the California Assessment Program, later renamed the California Learning Assessment System (CLAS). Discusses controversies over removal of certain writing prompts and objections to CLAS. Notes that funding for CLAS was vetoed in 1994.
Heterogeneidade dos déficits cognitivo e motor na esclerose múltipla: um estudo com a MSFC

Heterogeneous neuropsychological manifestations of multiple sclerosis (MS) difficult identification of patients with cognitive impairments. Cluster analyses were used to discriminate between groups of 40 MS patients and 48 demographically comparable control participants, using the three instruments of the Multiple Sclerosis Functional Composite Measure (MSFC): PASAT (cognition), Nine Hole Peg Test (manual dexterity), and Time to Walk 25 Feet. Four clusters resulted. In the first one were classified only noncompromised participants. The fourth cluster was composed by patients with major cognitive and motor impairments. Both patients and controls were found in two intermediate groups, one characterized by minor and the other by moderate lower cognitive performance. Significant diffences between clusters were found with ANOVA. Cognitive performance covaried with age and formal schooling. Most MS patients could not be accurately distinguished from controls, but one group was characterized by both cognitive and motor impairmens, which may dissociate at initial stages of disease. Keywords: Multiple sclerosis; cognition; neuropsychology; MSFC; cluster analysis.
Evidence of a local mechanism for desmopressin-induced tissue-type plasminogen activator release in human forearm.

Systemic administration of desmopressin (DDAVP) induces increased plasma levels of tissue-type plasminogen activator (t-PA), coagulation factor VIII, and von Willebrand factor (vWF). However, the mechanisms behind these responses are not known. We tested the hypothesis that DDAVP acts as a local stimulator of acute endothelial release of t-PA and vWF independently of central pathways. Healthy, young, nonsmoking male volunteers were studied. In a first study (n = 7), DDAVP and placebo were administered as randomized single-blind stepwise intrabrachial artery infusions (0.7, 7.0, and 70 ng/min). In a another subset of subjects (n = 4), a constant-rate DDAVP infusion of 70 ng/min was administered for 20 minutes in the brachial artery of the nondominant arm with the dominant arm as control. To rule out that the observed t-PA release was flow-dependent, 4 additional subjects received stepwise intra-arterial infusions of both DDAVP (7.0, 21, and 70 ng/min) and sodium nitroprusside (SNP; 0.5, 2.5, and 10 micrograms/min). Brachial venoarterial plasma concentration gradients and forearm plasma flow were used to determine net release/uptake rates of t-PA and vWF. At baseline, the average net release rate of t-PA was 6.7 ng/min across the whole forearm vascular bed, whereas there was no detectable basal release of vWF. Stepwise infusion of DDAVP induced a massive regulated release of t-PA with a peak after 15 minutes on the highest dose-step (ANOVA; P < .0001). The average maximum net release rate was 178 ng/min, and the total amount of t-PA released was, on the average, 3,000 ng. The majority was released in its active form. Constant-rate DDAVP infusion again markedly increased t-PA release in the infusion arm but had no effect whatsoever in the control arm. In contrast, DDAVP did not stimulate a local release of vWF in either study. Central hemodynamics were unchanged during infusions despite a local vasodilatory response with DDAVP. Endothelium-independent flow stimulation by SNP did not elicit any local t-PA release. We conclude that DDAVP induces a massive acute flow-independent release of t-PA, without the simultaneous release of vWF, in the human forearm vascular bed. The lack of a t-PA response in the control arm, as well as the unaltered central hemodynamics with DDAVP, confirms that the observed regulated t-PA release is local and independent of central mechanisms.
Correlation between clinical clerkship achievement and objective structured clinical examination (OSCE) scores of graduating dental students on conservative dentistry

Objectives This study aimed to investigate the effect of clinical clerkship-associated achievements, such as performance of procedures at the student clinic, observation, and attitude towards a clerkship, on the objective structured clinical examination (OSCE) scores of dental students graduating in restorative dentistry. Materials and Methods The OSCEs consisted of two stations designed to assess students' clinical skills regarding cavity preparation for a class II gold inlay and a class IV composite restoration. The clerkship achievements, consisting of the number of student clinical procedures performed, observation-related OSCE, and scores of their attitudes towards a conservative dentistry clerkship, were assessed. Correlation and multiple regression analyses were conducted. Results The correlation coefficient between the OSCE scores for cavity preparation for a class II gold restoration and clerkship attitude scores was 0.241 (p < 0.05). Regarding a class IV composite restoration, OSCE scores showed statistically significant correlations with the observation (r = 0.344, p < 0.01) and attitude (r = 0.303, p < 0.01) scores. In a multiple regression analysis, attitudes towards a clerkship (p = 0.033) was associated with the cavity preparation for a class II gold inlay OSCE scores, while the number of procedure observations (p = 0.002) was associated with the class IV composite restoration OSCE scores. Conclusions The number of clinical procedures performed by students, which is an important requirement for graduation, showed no correlation with either of the OSCEs scores.
Long-term outcomes and costs of ventricular assist devices among Medicare beneficiaries.

CONTEXT In 2003, Medicare expanded coverage of ventricular assist devices as destination, or permanent, therapy for end-stage heart failure. Little is known about the long-term outcomes and costs associated with these devices. OBJECTIVE To examine the acute and long-term outcomes of Medicare beneficiaries receiving ventricular assist devices alone or after open-heart surgery. DESIGN, SETTING, AND PATIENTS Analysis of inpatient claims from the Centers for Medicare & Medicaid Services for the period 2000 through 2006. Patients were Medicare fee-for-service beneficiaries who received a ventricular assist device between February 2000 and June 2006 alone as primary therapy (primary device group; n = 1476) or after cardiotomy in the previous 30 days (postcardiotomy group; n = 1467). MAIN OUTCOME MEASURES Cumulative incidence of device replacement, device removal, heart transplantation, readmission, and death, accounting for censoring and competing risks. Patients were followed up for at least 6 months and factors independently associated with long-term survival were identified. Medicare payments were used to calculate total inpatient costs and costs per day outside the hospital. RESULTS Overall 1-year survival was 51.6% (n = 669) in the primary device group and 30.8% (n = 424) in the postcardiotomy group. Among primary device patients, 815 (55.2%) were discharged alive with a device. Of those, 450 (55.6%) were readmitted within 6 months and 504 (73.2%) were alive at 1 year. Of the 493 (33.6%) postcardiotomy patients discharged alive with a device, 237 (48.3%) were readmitted within 6 months and 355 (76.6%) were alive at 1 year. Mean 1-year Medicare payments for inpatient care for patients in the 2000-2005 cohorts were $178,714 (SD, $142,549) in the primary device group and $111,769 (SD, $95,413) in the postcardiotomy group. CONCLUSIONS Among Medicare beneficiaries receiving a ventricular assist device, early mortality, morbidity, and costs remain high. Improving patient selection and reducing perioperative mortality are critical for improving overall outcomes.
High Prevalence of Metabolic Syndrome Features in Patients Previously Treated for Nonfunctioning Pituitary Macroadenoma

Objective Patients treated for nonfunctioning pituitary macroadenoma (NFMA) with suprasellar extension show disturbed sleep characteristics, possibly related to hypothalamic dysfunction. In addition to hypopituitarism, both structural hypothalamic damage and sleep restriction per se are associated with the metabolic syndrome. However, the prevalence of the metabolic syndrome in patients with NFMA is not well established. Our objective was to study the prevalence and risk factors for (components of) the metabolic syndrome in patients treated for NFMA. Design The metabolic syndrome (NCEP-ATP III criteria) was studied in an unselected cohort of 145 NFMA patients (aged 26–88yr, 44% female) in long-term remission after treatment, receiving adequate stable hormone replacement for any pituitary deficiencies. The results were compared to population data of 63,995 Dutch inhabitants by standardization (LifeLines cohort study). Results NFMA patients showed increased risk for reduced HDL-cholesterol (SMR 1.59, 95% CI 1.13–2.11), increased triglyceride levels (SMR 2.31, 95% CI 1.78–2.90) and the metabolic syndrome (SMR 1.60, 95% CI 1.22–2.02), but not for increased blood pressure, waist circumference or hyperglycemia. Preoperative visual field defects independently affected the risk for increased blood pressure (OR 6.5, 95% CI 1.9–22.2), and hypopituitarism was associated with a body mass index - dependent risk for increased waist circumference (OR 1.6, 95% CI 1.2–2.2) and the metabolic syndrome (OR 1.4, 95% CI 1.0–1.9). Conclusions Patients treated for NFMA are increased at risk for developing the metabolic syndrome, mainly due to decreased HDL-cholesterol and increased triglycerides. Risk factors included hypopituitarism and preoperative visual field defects. Hypothalamic dysfunction may explain the metabolic abnormalities, in addition to intrinsic imperfections of hormone replacement therapy. Additional research is required to explore the relation between derangements in circadian rhythmicity and metabolic syndrome in these patients.
Pre-st ret ch ( a ) Compliant electrodes

Dielectric elastomer actuators (DEAs), a soft actuator technology, hold great promise for biomimetic underwater robots. The high-voltages required to drive DEAs can however make them challenging to use in water. This paper demonstrates a method to create DEA-based biomimetic swimming robots that operate reliably even in conductive liquids. We ensure the insulation of the high-voltage DEA electrodes without degrading actuation performance by laminating silicone layers. A fish and a jellyfish were fabricated and tested in water. The fish robot has a length of 120 mm and a mass of 3.8 g. The jellyfish robot has a 61 mm diameter for a mass of 2.6 g. The measured swimming speeds for a periodic 3 kV drive voltage were ∼8 mm/s for the fish robot, and ∼1.5 mm/s for the jellyfish robot.
An Active Resource Orchestration Framework for PAN-Scale, Sensor-Rich Environments

In this paper, we present Orchestrator, an active resource orchestration framework for a PAN-scale sensor-rich mobile computing platform. Incorporating diverse sensing devices connected to a mobile phone, the platform will serve as a common base to accommodate personal context-aware applications. A major challenge for the platform is to simultaneously support concurrent applications requiring continuous and complex context processing, with highly scarce and dynamic resources. To address the challenge, we build Orchestrator, which actively coordinates applications' resource uses over the distributed mobile and sensor devices. As a key approach, it adopts an active resource use orchestration, which prepares multiple alternative plans for application requests and selectively applies them according to resource availability and demands at runtime. Through the selection, it resolves resource contention among applications and helps them efficiently share resources. With such system-level supports, applications become capable of providing long-running services under dynamic circumstances with scarce resources. Also, the platform can host a number of applications stably, exploiting its full resource capacity. We build an Orchestrator prototype on off-the-shelf mobile devices and sensor motes and show its effectiveness in terms of application supportability and resource use efficiency.
No-Reference Algorithms for Video Quality Assessment based on Artifact Evaluation in MPEG-2 and H . 264 Encoding Standards

In this paper, we propose two algorithms to assess quality in video sequences when no reference is available. The algorithms are the result of measuring artifacts such as blurring or tiling to the decoded image; firstly tested in MPEG-2 compression standard, and subsequently, analyzing the passage from this standard to its evolution H.264, taking into account its advanced techniques to mask the degradation, for example, the deblocking filtering or the variation in macroblocks size. The result of each metric affects in a different way depending on the spatial and temporal complexity of the video sequence. Several tests have been developed in a collection of representative sequences to demonstrate the efficiency of the algorithms. Keywords— Video Quality Assesment, No-Reference, H.264, Tiling, Blurring.
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Early Science Career Patterns of Recent Graduates from Leading Research Universities

This study examines the extent that the tight academic job market of the 1970’s enabled less prestigious institutions to attract new employees with doctorates from the most prestigious universities. A refinement of the Carnegie Council on Policy Studies in Higher Education categories is introduced in analysing data from two national surveys conducted by the National Academy of Sciences. Results point to an uneven “trickle-down” effect, as well as shifts within the Carnegie Council categories as to new Ph.D.’s employed.
Sudden cardiac death in diabetes mellitus: risk factors in the Rochester diabetic neuropathy study

Objectives: To determine risk factors for sudden cardiac death and the role of diabetic autonomic neuropathy (DAN) in the Rochester diabetic neuropathy study (RDNS) Methods: Associations between diabetic and cardiovascular complications, including DAN, and the risk of sudden cardiac death were studied among 462 diabetic patients (151 type 1) enrolled in the RDNS. Medical records, death certificates, and necropsy reports were assessed for causes of sudden cardiac death. Results: 21 cases of sudden cardiac death were identified over 15 years of follow up. In bivariate analysis of risk covariates, the following were significant: ECG 1 (evolving and previous myocardial infarctions): hazard ratio (HR) = 4.4 (95% confidence interval (CI), 1.6 to 12.1), p = 0.004; ECG 2 (bundle branch block or pacing): HR = 8.6 (2.9 to 25.4), p<0.001; ECG 1 or ECG 2: HR = 4.2 (1.3 to 13.4), p = 0.014; and nephropathy stage: HR = 2.1 (1.3 to 3.4), p = 0.002. Adjusting for ECG 1 or ECG 2, autonomic scores, QTc interval, high density lipoprotein (HDL) cholesterol, 24 hour microalbuminuria, and 24 hour total proteinuria were significant. However, adjusting for nephropathy, none of the autonomic indices, QTc interval, HDL cholesterol, microalbuminuria, or total proteinuria was significant. At necropsy, all patients with sudden cardiac death had coronary artery or myocardial disease. Conclusions: Sudden cardiac death was correlated with atherosclerotic heart disease and nephropathy, and to a lesser degree with DAN and HDL cholesterol. Although DAN is associated with sudden cardiac death, it is unlikely to be its primary cause.
Elevated Expression of GM3 in Receptor-Bearing Targets Confers Resistance to Human Immunodeficiency Virus Type 1 Fusion

ABSTRACT GM3, a major ganglioside of T lymphocytes, promotes human immunodeficiency virus type 1 (HIV-1) entry via interactions with HIV-1 receptors and the viral envelope glycoprotein (Env). Increased GM3 levels in T lymphocytes and the appearance of anti-GM3 antibodies in AIDS patients have been reported earlier. In this study, we investigated the effect of GM3 regulation on HIV-1 entry by utilizing a mouse cell line (B16F10), which expresses exceptionally high levels of GM3. Strikingly, B16 cells bearing CD4, CXCR4, and/or CCR5 were highly resistant to CD4-dependent HIV-1 Env-mediated membrane fusion. In contrast, these targets supported membrane fusion mediated by CD4-requiring HIV-2, SIV, and CD4-independent HIV-1 Envs. Coreceptor function was not impaired by GM3 overexpression as indicated by Ca2+ fluxes mediated by the CXCR4 ligand SDF-1α and the CCR5 ligand MIP-1β. Reduction in GM3 levels of B16 target cells resulted in a significant recovery of CD4-dependent HIV-1 Env-mediated fusion. We propose that GM3 in the plasma membrane blocks HIV-1 Env-mediated fusion by interfering with the lateral association of HIV-1 receptors. Our findings offer a novel mechanism of interplay between membrane lipids and receptors by which host cells may escape viral infections.