Miracle-dz/UniFAR-FTUs huggingface dataset:
Prediction of short cardiovascular variability signals based on conditional distribution

A new approach measuring the predictability of a process is proposed. The predictor is defined as the median of the distribution conditioned by a sequence of L-1 previous samples (i.e., a pattern). A function referred to as the corrected mean squared predictor error is defined to prevent the perfect adequacy to the data (i.e., the decrease to zero of the prediction error), thus avoiding to divide the whole set of data in learning and test sets. This function exhibits a minimum and this minimum is taken as a measure of predictability of the series. The use of the minimization procedure avoids to fix a priori the pattern length L. This approach permits one a reliable measure of predictability on short data sequences (around 300 samples). Moreover, this method, in connection with a surrogate data approach, is useful to detect nonlinear dynamics. The analysis indicates that, in simulated and real data, predictability and nonlinearity measures provide different information. The application of this approach to the analysis of cardiovascular variability series of the heart period (RR interval) and systolic arterial pressure (SAP) shows: (1) SAP series is more predictable than RR interval series; (2) predictability of the RR interval series is larger during tilt, during controlled respiration at 10 breaths/min (bpm) and after high-dose administration of atropine; (3) SAP series is dominated by linear correlation; (4) RR interval series exhibits nonlinear dynamics during controlled respiration at 10 bpm and after low-dose administration of atropine, while it is linear during sympathetic activation produced by tilt and after peripheral parasympathetic blockade caused by high-dose administration of atropine.
Differential production of reactive oxygen species by subsets of human spermatozoa at different stages of maturation.

BACKGROUND Reactive oxygen species (ROS)-mediated damage to human spermatozoa has been implicated in the pathogenesis of male infertility. Although ROS production by human spermatozoa has been extensively studied, the cell-to-cell variation in ROS production by spermatozoa at different stages of maturation has never been investigated. METHODS In this study, we determined ROS production by subsets of human spermatozoa at different stages of maturation isolated by density gradient centrifugation of ejaculated spermatozoa obtained from healthy donors and from patients attending a clinic for infertility screening. RESULTS Four different fractions were obtained. ROS production was highest in immature spermatozoa with abnormal head morphology and cytoplasmic retention and lowest in mature spermatozoa and immature germ cells (P < 0.01). ROS production was highest in immature spermatozoa from males with abnormal semen parameters compared with donors (P < 0.0001) or patients with normal semen parameters (P = 0.015). ROS production by immature spermatozoa was inversely correlated with the recovery of motile, mature spermatozoa in the high density fraction 4 (P = 0.01). CONCLUSIONS The results of this study indicate that there is significant cell-to-cell variation in ROS production in subsets of spermatozoa at different stages of maturation and that oxidative damage of mature spermatozoa by ROS-producing immature spermatozoa during sperm migration from the seminiferous tubules to the epididymis may be an important cause of male infertility.
Polarised skylight and the landmark panorama provide night-active bull ants with compass information during route following

SUMMARY Navigating animals are known to use a number of celestial and terrestrial compass cues that allow them to determine and control their direction of travel. Which of the cues dominate appears to depend on their salience. Here we show that night-active bull ants attend to both the pattern of polarised skylight and the landmark panorama in their familiar habitat. When the two directional cues are in conflict, ants choose a compromise direction. However, landmark guidance appears to be the primary mechanism of navigation used by forager ants, with those cues in the direction of heading having the greatest influence on navigation. Different colonies respond to the removal of these cues to different degrees, depending on the directional information provided by the local landmark panorama. Interestingly, other parts of the surrounding panorama also influence foraging speed and accuracy, suggesting that they too play a role in navigation.
Biomarkers and Algorithms for the Diagnosis of Vitamin B12 Deficiency

Vitamin B12 (cobalamin, Cbl, B12) is an indispensable water-soluble micronutrient that serves as a coenzyme for cytosolic methionine synthase (MS) and mitochondrial methylmalonyl-CoA mutase (MCM). Deficiency of Cbl, whether nutritional or due to inborn errors of Cbl metabolism, inactivate MS and MCM leading to the accumulation of homocysteine (Hcy) and methylmalonic acid (MMA), respectively. In conjunction with total B12 and its bioactive protein-bound form, holo-transcobalamin (holo-TC), Hcy, and MMA are the preferred serum biomarkers utilized to determine B12 status. Clinically, vitamin B12 deficiency leads to neurological deterioration and megaloblastic anemia, and, if left untreated, to death. Subclinical vitamin B12 deficiency (usually defined as a total serum B12 of <200 pmol/L) presents asymptomatically or with rather subtle generic symptoms that oftentimes are mistakenly ascribed to unrelated disorders. Numerous studies have now established that serum vitamin B12 has limited diagnostic value as a stand-alone marker. Low serum levels of vitamin B12 not always represent deficiency, and likewise, severe functional deficiency of the micronutrient has been documented in the presence of normal and even high levels of serum vitamin B12. This review discusses the usefulness and limitations of current biomarkers of B12 status in newborn screening, infant and adult diagnostics, the algorithms utilized to diagnose B12 deficiency and unusual findings of vitamin B12 status in various human disorders.
Edinburgh Research Explorer Genomic profiling of microRNAs and messenger RNAs reveals hormonal regulation in microRNA expression in human endometrium

MicroRNAs (miRNAs), a class of small noncoding RNAs that regulate gene expression, have fundamental roles in biological processes, including cell differentiation and proliferation. These small molecules mainly direct either target messenger RNA (mRNA) degradation or translational repression, thereby func-tioning as gene silencers. Epithelial cells of the uterine lumen and glands undergo cyclic changes under the influence of the sex steroid hormones estradiol-17beta and progesterone. Because the expression of miRNAs in human endometrium has been established, it is important to understand whether miRNAs have a physiological role in modulating the expression of hormonally induced genes. The studies herein establish concomitant differential miRNA and mRNA expression profiles of uterine epithelial cells purified from endometrial biopsy specimens in the late proliferative and midsecretory phases. Bioinformatics analysis of differentially expressed mRNAs revealed cell cycle regulation as the most significantly enriched pathway in the late proliferative-phase endometrial epithelium ( P ¼ 5.7 3 10 (cid:2) 15 ). In addition, the WNT signaling pathway was enriched in the proliferative phase. The 12 miRNAs ( MIR29B, MIR29C, MIR30B, MIR30D, MIR31, MIR193A-3P, MIR203, MIR204, MIR200C, MIR210, MIR582-5P, and MIR345 ) whose expression was significantly up-regulated in the midsecretory-phase samples were predicted to target many cell cycle genes. Consistent with the role of miRNAs in suppressing their target mRNA expression, the transcript abundance of predicted targets, including cyclins and cyclin-dependent kinases, as well as E2F3 (a known target of MIR210 ), was decreased. Thus, our findings suggest a role for miRNAs in down-regulating the expression of some cell cycle genes in the secretory-phase endometrial epithelium, thereby suppressing cell proliferation.
Component module classification for distributed software understanding

Effective analysis and evolution of existing distributed software systems rely to great an extent on the ability to recognise implemented executable components, particularly their constituent modules. Traditionally, this information is obtained via manual examination of configuration files and the source code directory hierarchy. However both types of artifact are limited in distinguishing which modules are used exclusively by each executable component. This exclusivity distinction is important in that it helps to understand the components' unique functionalities and their potential runtime behaviour. This paper presents a module classification technique that can facilitate automatic recognition of executable component modules in a distributed system. In contrast to existing approaches, the technique explicitly distinguishes component exclusive modules from modules shared by multiple components. The paper illustrates the benefits of the technique by reporting on the results of a case study where it has been useful to (a) revealing component exclusive modules in the source code for the field distributed programming environment; and (b) investigating some aspects of an implicit-invocation model of field described elsewhere. Applications of the technique to other software engineering tasks, such as change impact analysis, reuse and restructuring, are also discussed.
The Genus Neoceratium (Planktonic Dinoflagellates) as a Potential Indicator of Ocean Warming

Among the planktonic dinoflagellates, the species-rich genus Neoceratium has particularly remarkable features that include its easily recognizable outline and large size. This ubiquitous genus shows consistent presence in all plankton samples and has been a model for numerous studies since the end of the 19th century. It has already been described as a good candidate to monitor water masses and describe ocean circulation. We argue that the sensitivity displayed by Neoceratium to water temperature also makes it relevant as an indicator of ocean warming. The advantages and interests of using Neoceratium species to monitor climate change on a large scale are reassessed in view of recent advances in understanding their biology and ecology.
Audio visual and Multimodal Speech Systems

In human human communication signals from multiple channels are at work We communi cate not only through words but also by intonation gaze hand and body gestures and facial expressions These verbal and nonverbal signals have a role in the communicative process They add modify substitute information in discourse and are highly linked with each other The ease and robustness of human human communication is due to extremely high recognition accuracy using multiple input channels and the redundant and complimentary use of several modalities Human computer interaction can bene t from modeling several modalities in analogous ways Multimodal systems represent and manipulate information from di erent human communication channels at mul tiple levels of abstraction The purpose of this chapter is to present current work towards establishing standards and common resources for multimodal systems The chapter covers an overview and survey of current multimodal systems and clari es the basic terminology It also provides recommendations on the di erent com ponents of such systems More particularly this chapter focuses on multimodal systems that have speech either as input or output modality The chapter discusses aspects of the various types of multimodal systems according to what speech and non speech modalities speech input and output is associated with It describes systems that combine speech input with information from the visual channel face detection face recognition tracking of facial features and lip reading Systems using talking faces and conversational agents combination of speech with visual output are also presented Another object of attention of the chapter is on the concepts and issues related to multimodal systems combining speech input with other input modalities as well as to systems combining speech output with other modalities The details of the technology necessary to implement such systems are also reviewed
Kinematics and Dynamics of an Asymmetrical Parallel Robotic Wrist

This paper introduces an asymmetrical parallel robotic wrist, which can generate a decoupled unlimited-torsion motion and achieve high positioning accuracy. The kinematics, dexterity, and singularities of the manipulator are investigated to visualize the performance contours of the manipulator. Using the method of Lagrange multipliers and considering all the mobile components, the equations of motion of the manipulator are derived to investigate the dynamic characteristics efficiently. The developed dynamic model is numerically illustrated and compared with its simplified formulation to show its computation accuracy.
Efficacy of Handwashing with Soap and Nail Clipping on Intestinal Parasitic Infections in School-Aged Children: A Factorial Cluster Randomized Controlled Trial

Background Intestinal parasitic infections are highly endemic among school-aged children in resource-limited settings. To lower their impact, preventive measures should be implemented that are sustainable with available resources. The aim of this study was to assess the impact of handwashing with soap and nail clipping on the prevention of intestinal parasite reinfections. Methods and Findings In this trial, 367 parasite-negative school-aged children (aged 6–15 y) were randomly assigned to receive both, one or the other, or neither of the interventions in a 2 × 2 factorial design. Assignment sequence was concealed. After 6 mo of follow-up, stool samples were examined using direct, concentration, and Kato-Katz methods. Hemoglobin levels were determined using a HemoCue spectrometer. The primary study outcomes were prevalence of intestinal parasite reinfection and infection intensity. The secondary outcome was anemia prevalence. Analysis was by intention to treat. Main effects were adjusted for sex, age, drinking water source, latrine use, pre-treatment parasites, handwashing with soap and nail clipping at baseline, and the other factor in the additive model. Fourteen percent (95% CI: 9% to 19%) of the children in the handwashing with soap intervention group were reinfected versus 29% (95% CI: 22% to 36%) in the groups with no handwashing with soap (adjusted odds ratio [AOR] 0.32, 95% CI: 0.17 to 0.62). Similarly, 17% (95% CI: 12% to 22%) of the children in the nail clipping intervention group were reinfected versus 26% (95% CI: 20% to 32%) in the groups with no nail clipping (AOR 0.51, 95% CI: 0.27 to 0.95). Likewise, following the intervention, 13% (95% CI: 8% to 18%) of the children in the handwashing group were anemic versus 23% (95% CI: 17% to 29%) in the groups with no handwashing with soap (AOR 0.39, 95% CI: 0.20 to 0.78). The prevalence of anemia did not differ significantly between children in the nail clipping group and those in the groups with no nail clipping (AOR 0.53, 95% CI: 0.27 to 1.04). The intensive follow-up and monitoring during this study made it such that the assessment of the observed intervention benefits was under rather ideal circumstances, and hence the study could possibly overestimate the effects when compared to usual conditions. Conclusions Handwashing with soap at key times and weekly nail clipping significantly decreased intestinal parasite reinfection rates. Furthermore, the handwashing intervention significantly reduced anemia prevalence in children. The next essential step should be implementing pragmatic studies and developing more effective approaches to promote and implement handwashing with soap and nail clipping at larger scales.
Opus: University of Bath Online Publication Store Atomic Lambda-calculus: a Typed Lambda-calculus with Explicit Sharing

(2013) Atomic lambda-calculus:A typed lambda-calculus with explicit sharing. from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. This version is made available in accordance with publisher policies. Please cite only the published version using the reference above. Abstract—An explicit–sharing lambda-calculus is presented, based on a Curry–Howard-style interpretation of the deep inference proof formalism. Duplication of subterms during reduction proceeds 'atomically', i.e. on individual constructors, similar to optimal graph reduction in the style of Lamping. The calculus preserves strong normalisation with respect to the lambda-calculus, and achieves fully lazy sharing.
Oral oseltamivir treatment of influenza in children

Background. Oral oseltamivir administration is effective treatment for influenza in adults. This study was conducted to determine the efficacy, safety and tolerability of oseltamivir in children with influenza. Methods. In this randomized, double blind, placebo-controlled study, children 1 through 12 years with fever [≥100°F (≥38°C)] and a history of cough or coryza <48 h duration received oseltamivir 2 mg/kg/dose or placebo twice daily for 5 days. The primary efficacy endpoint was the time to resolution of illness including mild/absent cough and coryza mild/absent, return to normal activity and euthermia. Results. Of 695 enrolled children 452 (65%) had influenza (placebo, n = 235; oseltamivir, n = 217). Among infected children the median duration of illness was reduced by 36 h (26%) in oseltamivir compared with placebo recipients (101 h; 95% confidence interval, 89 to 118 vs. 137 h; 95% confidence interval, 125 to 150;P < 0.0001). Oseltamivir treatment also reduced cough, coryza and duration of fever. New diagnoses of otitis media were reduced by 44% (12%vs. 21%). The incidence of physician-prescribed antibiotics was significantly lower in influenza-infected oseltamivir (68 of 217, 31%) than placebo (97 of 235, 41%;P = 0.03) recipients. Oseltamivir therapy was generally well-tolerated, although associated with an excess frequency of emesis (5.8%). Discontinuation because of adverse events was low in both groups (1.8% with oseltamivir vs. 1.1% with placebo). Oseltamivir treatment did not affect the influenza-specific antibody response. Conclusions. Oral oseltamivir administration is an efficacious and well-tolerated therapy for influenza in children when given within 48 h of onset of illness.
An implementation of modified nodal array approach in designing a readout circuit for piezoresistive pressure sensor array

In this paper, we modified the Nodal Array Approach (NAA) in designing readout circuit for piezoresistive pressure sensor array to include more sensors in a network and rearranging the topology of the variable resistors for more efficiency and accuracy in producing the results. In order to maximize the number of sensors that can be read in a single network, NAA's reading technique also needs to be modified and extended to more than 4 iterations readings. Furthermore, the modified topology of variable resistors locations has indirectly remove its previous limitation of uniqueness and permutation. An additional work has been done in dividing the sensor's resistance value into range group in order to suit the pressure sensor's behavior characteristic. For any sensor that operating in a specific range of operation, the results can achieved lower than 5% of calculation error by comparing to its real value.
Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives

Silymarin (SM), an extract from the Silybum marianum (milk thistle) plant containing various flavonolignans (with silybin being the major one), has received a tremendous amount of attention over the last decade as a herbal remedy for liver treatment. In many cases, the antioxidant properties of SM are considered to be responsible for its protective actions. Possible antioxidant mechanisms of SM are evaluated in this review. (1) Direct scavenging free radicals and chelating free Fe and Cu are mainly effective in the gut. (2) Preventing free radical formation by inhibiting specific ROS-producing enzymes, or improving an integrity of mitochondria in stress conditions, are of great importance. (3) Maintaining an optimal redox balance in the cell by activating a range of antioxidant enzymes and non-enzymatic antioxidants, mainly via Nrf2 activation is probably the main driving force of antioxidant (AO) action of SM. (4) Decreasing inflammatory responses by inhibiting NF-κB pathways is an emerging mechanism of SM protective effects in liver toxicity and various liver diseases. (5) Activating vitagenes, responsible for synthesis of protective molecules, including heat shock proteins (HSPs), thioredoxin and sirtuins and providing additional protection in stress conditions deserves more attention. (6) Affecting the microenvironment of the gut, including SM-bacteria interactions, awaits future investigations. (7) In animal nutrition and disease prevention strategy, SM alone, or in combination with other hepatho-active compounds (carnitine, betaine, vitamin B12, etc.), might have similar hepatoprotective effects as described in human nutrition.
Time‐Dependent Deformations of Sandstone During Pore Fluid Pressure Oscillations: Implications for Natural and Induced Seismicity

In tectonically active regions, natural seismicity is often correlated with the seasonal hydrology, suggesting that cyclic loading variations might trigger seismicity. Moreover, recent field observations suggest that cyclic fluid injection strategies into geological reservoirs could produce less seismicity than monotonic injections. Here we present 10 brittle creep laboratory triaxial experiments that bring new constraints on fluid‐rock interactions during cyclic pore fluid variations. The experiments were performed on Fontainebleau sandstone with various pore fluid pressure conditions: (i) with constant pore fluid pressure levels from 1 to 10 MPa, at constant Terzaghi effective pressure (Pc − Pf = 30 MPa); and (ii) with cyclic (sinusoidal) pore fluid pressure oscillations of varying amplitudes (from 0 to 8 MPa) and periods (from 30 to 3,000 s) around a mean value of 5 MPa. During deformation, the rock's mechanical properties and the high‐frequency acoustic emission signals were monitored to investigate the physics underlying the rupture processes. Under macroscopically drained conditions, rather than their amplitude, the period of the oscillations appeared to strongly affect the rock sample strength, time‐to‐failure, and dilatancy behavior. Moreover, even for small variations of pore fluid amplitude, and at all pore fluid pressure period, pore fluid pressure and acoustic emissions were strongly correlated. Our experiments demonstrate that pore fluid pressure oscillations may strongly affect rocks mechanical behavior and associated seismic activity.