Miracle-dz/UniFAR-FTUs huggingface dataset:
Loss of DPC4 expression and its correlation with clinicopathological parameters in pancreatic carcinoma.

AIM DPC4 is a tumor suppressor gene on chromosome 18q21.1 that has high mutant frequencies in pancreatic carcinogenesis. The purpose of this study was to investigate the role of DPC4 alterations in tumorigenesis and progression of pancreatic carcinomas. METHODS We studied the immunohistochemical markers of DPC4 in 34 adenocarcinomas and 16 nonmalignant specimens from the pancreas. The 16 nonmalignant specimens from the pancreas included 8 non-neoplastic cysts and 8 normal pancreatic tissues. The relationship between DPC4 alterations and various clinicopathological parameters was evaluated by chi-square test or Fisher's exact test. Survivals were calculated using Kaplan-Meier method (by a log-rank test). RESULTS All the 16 nonmalignant cases of the pancreas showed expression of DPC4 gene. Loss of DPC4 expression was seen in 8 of 34(23.5%) pancreatic adenocarcinomas. The frequency of loss of DPC4 expression was higher in poorly differentiated adenocarcinoma (G3) than in well and moderately differentiated adenocarcinoma (G1 and G2) histologically (P=0.037). Loss of DPC4 expression of the patients at TNM stage IV was also higher than that of the patients at TNM stages I, II and III (60.0% at stage IV, versus 14.3% at stage I, 18.2% at stage II, and 18.2% at stage III) (P=0.223). The mean and median survival in patients with DPC4 expression was longer than those in patients with loss of DPC4 expression. Kaplan-Meier survival analysis demonstrated patients with DPC4 expression had a higher survival rate than patients with loss of DPC4 expression, but the difference did not reach statistical significance (P=0.879). CONCLUSION This study suggests that DPC4 is involved in the development of pancreatic carcinoma and is a late event in pancreatic carcinogenesis, DPC4 expression may be a molecular prognostic marker for pancreatic carcinoma.
Coupling of voltage-dependent gating and Ba++ block in the high- conductance, Ca++-activated K+ channel

Voltage-dependent Ca++-activated K+ channels from rat skeletal muscle were reconstituted into planar lipid bilayers, and the kinetics of block of single channels by Ba++ were studied. The Ba++ association rate varies linearly with the probability of the channel being open, while the dissociation rate follows a rectangular hyperbolic relationship with open-state probability. Ba ions can be occluded within the channel by closing the channel with a strongly hyperpolarizing voltage applied during a Ba++-blocked interval. Occluded Ba ions cannot dissociate from the blocking site until after the channel opens. The ability of the closed channel to occlude Ba++ is used as an assay to study the channel's gating equilibrium in the blocked state. The blocked channel opens and closes in a voltage- dependent process similar to that of the unblocked channel. The presence of a Ba ion destabilizes the closed state of the blocked channel, however, by 1.5 kcal/mol. The results confirm that Ba ions block this channel by binding in the K+-conduction pathway. They further show that the blocking site is inaccessible to Ba++ from both the cytoplasmic and external solutions when the channel is closed.
Fatal Interstitial Lung Disease after Addition of Sorafenib to a Patient with Lung Adenocarcinoma Who Had Failed to Improve with Erlotinib Alone

Interstitial lung disease (ILD) induced by epidermal growth factor receptor tyrosine kinase inhibitors has been extensively documented with decreasing incidence after appropriate patient selection due to increasing awareness over the years. However, ILD induced by sorafenib was mentioned with lower frequency only in patients with hepatocellular and renal cell carcinoma living in Japan but not in patients with other carcinomas or living outside Japan, and it has been overlooked in clinical practice. In the present case, sorafenib was added to the treatment of a 60-year-old non-smoking patient with non-small cell lung cancer (NSCLC). After his failing to improve with erlotinib alone, erlotinib was continued to be given in combination with sorafenib as a salvage therapy. Although clinical signs of ILD were observed 2 weeks after the addition of sorafenib, the radiological diagnosis of ILD was only made 41 days after the initiation of the combination treatment, and the patient died 56 days after treatment onset. It was concluded that ILD was indeed induced by sorafenib. This is the first report of ILD induced by sorafenib in a patient with NSCLC living outside Japan. Oncologists should be aware of this fatal complication for its early detection in order to avoid a severe course of ILD leading to a decrease in the ILD mortality rate.
Sonification of surface tapping: Influences on behaviour, emotion and surface perception

Interaction sounds when tapping on a surface provide information about the material of the surface and about one’s own motor behaviour. With the current developments in interactive sonification, it is now possible to digitally change this audio - feedback resulting from object interaction. Here we evaluated a model for a sonic interactive surface . This model uses a system capable of delivering surface tapping sounds in real-time , when triggered by the users’ taps on a real surface or on an imagined, “virtual” surface (i.e., when tapping in the air). Across different conditions the audio - feedback was varied so that the heard tapping sounds corresponded to different applied strength during tapping. We evaluated the effect of the altered tapping sounds on emotional action - related responses: perceived effort and aggressiveness when tapping on the surface, emotional valence, dominance, and arousal measured through self-report and biosensors, participants’ way of interacting with the surface: maximum acceleration and frequency of tapping movement, and surface perception: perceptual quality of hardness. Results show the influence of the sonification of surface tapping at all levels: emotional, behavioral and perceptual. We conclude by addressing some implications of our results in the design of interactive sonification displays and tangible auditory interfaces aiming to change perceived and subsequent motor behaviour, as well as perceived material properties.
Identification and Analysis of Skype Peer-to-Peer Traffic

More and more applications are adopting peer-to-peer (P2P) technology. Skype is a P2P based, popular VoIP software. The software works almost seamlessly across Network Address Translations (NATs) and firewalls and has better voice quality than most IM applications. The communication protocol and source code of Skype are undisclosed. It uses high strength encryption and random port number selection, which render the traditional flow identification solutions invalid. In this paper, we first obtain the Skype clients and super nodes by analyzing the process of login and calling in different network environments. Then we propose a method to identify Skype traffic based on Skype nodes and flow features. Our proposed method makes the previously hard-to-detect Skype traffic, especially voice service traffic, much easier to identify. We design an identification system utilizing the proposed method and implement the system in a LAN network. We also successfully identified Skype traffic in one of the largest Internet Providers over a period of 93 hours, during which over 30TB data were transmitted. Through experiments, we show that our proposed approach and implementations can indeed identify Skype traffic with higher accuracy and effectiveness.
Factors associated with acquisition and clearance of human papillomavirus infection in a cohort of US men: a prospective study.

BACKGROUND Our understanding of factors associated with acquisition and clearance of human papillomavirus (HPV) in men has been limited. This study sought to determine factors associated with those aspects of HPV infection in a cohort of US men. METHODS A total of 285 men aged 18-44 years were monitored every 6 months for approximately 18 months. Risk-factor information was obtained at each visit by use of a self-administered questionnaire. A continuous-time 2-state Markov model was applied. RESULTS Lifetime number of sex partners reported at enrollment was the most significant risk factor for acquisition of all types of HPV. Men reporting >16 lifetime sex partners were at significantly elevated risk of any HPV infection (adjusted hazard ratio [AHR], 2.8 [95% confidence interval {CI}, 1.1-7.1]), oncogenic HPV infection (AHR, 9.6 [95% CI, 2.4-37.8]), and nononcogenic HPV infection (AHR, 3.6 [95% CI, 1.3-9.9]), compared with those reporting 0-4 partners. Circumcised men were 3 and 6 times more likely to clear infection with any and oncogenic HPV types, respectively. In addition, having had >16 lifetime sex partners was associated with greater likelihood of clearance of oncogenic HPV infection (AHR, 4.9 [95% CI, 1.2-19.8]). CONCLUSION The key factor associated with acquisition of HPV was lifetime number of sex partners, whereas circumcision was the most significant determinant for clearance of any HPV infection and oncogenic HPV infection.
Coder Reliability and Misclassification in the Human Coding of Party Manifestos

The Comparative Manifesto Project (CMP) provides the only time series of estimated party policy positions in political science and has been extensively used in a wide variety of applications. Recent work (e.g., Benoit, Laver, and Mikhaylov 2009; Klingemann et al. 2006) focuses on nonsystematic sources of error in these estimates that arise from the text generation process. Our concern here, by contrast, is with error that arises during the text coding process since nearly all manifestos are coded only once by a single coder. First, we discuss reliability and misclassification in the context of hand-coded content analysis methods. Second, we report results of a coding experiment that used trained human coders to code sample manifestos provided by the CMP, allowing us to estimate the reliability of both coders and coding categories. Third, we compare our test codings to the published CMP “gold standard” codings of the test documents to assess accuracy and produce empirical estimates of a misclassification matrix for each coding category. Finally, we demonstrate the effect of coding misclassification on the CMP's most widely used index, its left-right scale. Our findings indicate that misclassification is a serious and systemic problem with the current CMP data set and coding process, suggesting the CMP scheme should be significantly simplified to address reliability issues.
The Genus Cecropia: A Biological Clock to Estimate the Age of Recently Disturbed Areas in the Neotropics

Forest successional processes following disturbance take decades to play out, even in tropical forests. Nonetheless, records of vegetation change in this ecosystem are scarce, increasing the importance of the chronosequence approach to study forest recovery. However, this approach requires accurate dating of secondary forests, which until now was a difficult and/or expensive task. Cecropia is a widespread and abundant pioneer tree genus of the Neotropics. Here we propose and validate a rapid and straightforward method to estimate the age of secondary forest patches based on morphological observations of Cecropia trees. We found that Cecropia-inferred ages were highly correlated with known ages of the forest. We also demonstrate that Cecropia can be used to accurately date disturbances and propose twenty-one species distributed all over the geographical range of the genus as potential secondary forest chronometer species. Our method is limited in applicability by the maximal longevity of Cecropia individuals. Although the oldest chronosequence used in this study was 20 years old, we argue that at least for the first four decades after disturbance, the method described in this study provides very accurate estimations of secondary forest ages. The age of pioneer trees provides not only information needed to calculate the recovery of carbon stocks that would help to improve forest management, but also provides information needed to characterize the initial floristic composition and the rates of species remigration into secondary forest. Our contribution shows how successional studies can be reliably and inexpensively extended without the need to obtain forest ages based on expensive or potentially inaccurate data across the Neotropics.
Generalized hypercube structures and hyperswitch communication network

This paper discusses an ongoing study that uses a recent development in communication control technology to implement hybrid hypercube structures. These architectures are similar to binary hypercubes, but they also provide added connectivity between the processors. This added connectivity increases communication reliability while decreasing the latency of interprocessor message passing. Because these factors directly determine the speed that can be obtained by multiprocessor systems, these architectures are attractive for applications such as remote exploration and experimentation, where high performance and ultrareliability are required. This paper describes and enumerates these architectures and discusses how they can be implemented with a modified version of the hyperswitch communication network (HCN). The HCN is analyzed because it has three attractive features that enable these architectures to be effective: speed, fault tolerance, and the ability to pass multiple messages simultaneously through the same hyperswitch controller.
Comparison of input and feature space nonlinear kernel nuisance attribute projections for speaker verification

Nuisance attribute projection (NAP) was an effective method to reduce session variability in SVM-based speaker verification systems. As the expanded feature space of nonlinear kernels is usually high or infinite dimensional, it is difficult to find nuisance directions via conventional eigenvalue analysis and to do projection directly in the feature space. In this paper, two different approaches to nonlinear kernel NAP are investigated and compared. In one way, NAP projection is formulated in the expanded feature space and kernel PCA is employed to do kernel eigenvalue analysis. In the second approach, a gradient descent algorithm is proposed to find out projection over input variables. Experimental results on the 2006 NIST SRE corpus show that both kinds of NAP can reduce unwanted variability in nonlinear kernels to improve verification performance; and NAP performed in expanded feature space using kernel PCA obtains slightly better performance than NAP over input variables.
Structural Characterization and Function Determination of a Nonspecific Carboxylate Esterase from the Amidohydrolase Superfamily with a Promiscuous Ability To Hydrolyze Methylphosphonate Esters

The uncharacterized protein Rsp3690 from Rhodobacter sphaeroides is a member of the amidohydrolase superfamily of enzymes. In this investigation the gene for Rsp3690 was expressed in Escherichia coli and purified to homogeneity, and the three-dimensional structure was determined to a resolution of 1.8 Å. The protein folds as a distorted (β/α)8-barrel, and the subunits associate as a homotetramer. The active site is localized to the C-terminal end of the β-barrel and is highlighted by the formation of a binuclear metal center with two manganese ions that are bridged by Glu-175 and hydroxide. The remaining ligands to the metal center include His-32, His-34, His-207, His-236, and Asp-302. Rsp3690 was shown to catalyze the hydrolysis of a wide variety of carboxylate esters, in addition to organophosphate and organophosphonate esters. The best carboxylate ester substrates identified for Rsp3690 included 2-naphthyl acetate (kcat/Km = 1.0 × 105 M–1 s–1), 2-naphthyl propionate (kcat/Km = 1.5 × 105 M–1 s–1), 1-naphthyl acetate (kcat/Km = 7.5 × 103 M–1 s–1), 4-methylumbelliferyl acetate (kcat/Km = 2.7 × 103 M–1 s–1), 4-nitrophenyl acetate (kcat/Km = 2.3 × 105 M–1 s–1), and 4-nitrophenyl butyrate (kcat/Km = 8.8 × 105 M–1 s–1). The best organophosphonate ester substrates included ethyl 4-nitrophenyl methylphosphonate (kcat/Km = 3.8 × 105 M–1 s–1) and isobutyl 4-nitrophenyl methylphosphonate (kcat/Km = 1.1 × 104 M–1 s–1). The (SP)-enantiomer of isobutyl 4-nitrophenyl methylphosphonate was hydrolyzed 10 times faster than the less toxic (RP)-enantiomer. The high inherent catalytic activity of Rsp3690 for the hydrolysis of the toxic enantiomer of methylphosphonate esters make this enzyme an attractive target for directed evolution investigations.
DDoS Defense Mechanism by applying Stamps using Cryptography

current trend, internet plays a vital role in our life and distributed computing structure grows dramatically in size, functionality and complexity and has become the integral part of our life. In distributed network computing there are lot of vulnerabilities such as Dos, DDos (Distributed Denial of service),virus, worms, etc. Distributed Denial of Service Attacks has recently emerged as one of the most newsworthy. Denials of service (DoS) attacks have continued to evolve and impact Internet Infrastructure. The control mechanisms for DDoS attack networks are changing to make greater use of Internet Relay Chat (IRC) technology. The impacts of DDos attacks are causing greater collateral damage, and widespread automated propagation itself has become a vehicle for causing denial of service. In our paper we propose a solution to prevent our network system resources from DDos attacks applying stamps.
Socio-engineering Methodology for Cloud Computing Analysis

Detecting potential cloud computing services is part of business direction and strategic planning of enterprise IT management companies. However, this relative new territory examination requires careful analysis that incorporates both external and internal organization perspectives. The socio-engineering methodology for cloud computing analysis (SEC) employed in this paper is aimed at discovering the potential cloud services that are of interest to the company as a whole. The investigation results were inserted into the company strategic technological evaluation process. The methodology was based on both qualitative and quantitative analysis techniques, incorporating interviews, surveys, questioners and an iterative review process. The results formed the company’s cloud taxonomy, as well as highlighted 4 main players and 18 potential domains of services.
With Appreciation

The Scientific Committee and Congress Organizing Committee of the 2015 IPA International Congress would like to thank everyone who has contributed to the Scientific Program. Together we have produced a rich and diverse program, reflecting IPA's mission, which upholds its high standards of scientific quality. Appreciation is also extended to all members of the Scientific Committee for their dedication and hard work in helping to develop the program and assess all the abstracts prior to acceptance.
Nonoperative treatment of multiple intra-abdominal solid organ injury after blunt abdominal trauma.

BACKGROUND A number of large series' have attempted to examine the management of blunt solid organ injuries; however, only a few studies regarding multiple injuries exist. The aim of this study is to analyze whether multiple solid organ injury affects nonoperative management (NOM) and to look for predictive factors of NOM. METHODS All patients admitted with a diagnosis of blunt solid organ injury between January 1, 1999 and January 1, 2005 were included in this prospective observational study. Of the 468 patients who had solid organ injury, 46 patients met the inclusion criteria of multiple solid organ injuries. Presentation, mechanism of injury, injury grade, Abbreviated Injury Scale score, management, and outcomes were analyzed. Independent predictive factors of NOM failure were identified. Patients managed nonoperatively were compared with patients who had had emergent laparotomy and patients for whom NOM failed. RESULTS Fifteen patients (33%) underwent emergency laparotomy because of hypovolemic shock that was unresponsive to aggressive resuscitation, and 31 (66%) were selected for NOM. Among the 31 patients, NOM was successful in 23 (75%). No specific organ injury combination was found to affect NOM failure. Admission lactate level [odds ratio(OR), 1.44; 95% confidence interval (CI), 1.05-1.98; p = 0.025], a drop in the hematocrit greater than 20% in the first hour after admission (OR, 1.13; 95% confidence interval CI, 1.04-1.24; p = 0.007), and solid viscus score (OR, 1.67; 95% CI, 1.03-2.80; p = 0.04) were significant independent risk factors in those patients for whom NOM failed. In logistic regression analysis, hypotension at admission (OR, 0.96; 95% CI, 0.92-0.99; p = 0.014) and transfusion in the first 6 hours after admission (OR, 1.03; 95% CI, 1.00-1.05; p = 0.015) were found to significantly affect the success rate of nonoperative management. CONCLUSION Lactate levels at admission, solid viscus score, necessity of transfusion, crystalloid resuscitation, and a drop in the hematocrit in the first hour after admission are useful parameters for judging the failure of NOM. Although there is a higher failure rate of NOM in multiple solid organ injury, NOM can still be considered in these cases with extra caution.
A Principled Deep Random Field Model for Image Segmentation

We discuss a model for image segmentation that is able to overcome the short-boundary bias observed in standard pairwise random field based approaches. To wit, we show that a random field with multi-layered hidden units can encode boundary preserving higher order potentials such as the ones used in the cooperative cuts model of [11] while still allowing for fast and exact MAP inference. Exact inference allows our model to outperform previous image segmentation methods, and to see the true effect of coupling graph edges. Finally, our model can be easily extended to handle segmentation instances with multiple labels, for which it yields promising results.
Treatment and prognostic impact of transient leukemia in neonates with Down syndrome.

Approximately 10% of the neonates with Down syndrome (DS) exhibit a unique transient leukemia (TL). Though TL resolves spontaneously in most patients, early death and development of myeloid leukemia (ML-DS) may occur. Prognostic factors as well as treatment indication are currently uncertain. To resolve that issue, we prospectively collected clinical, biologic, and treatment data of 146 patients with TL. The 5-year overall survival (OS) and event-free survival (EFS) were 85% plus or minus 3% and 63% plus or minus 4%, respectively. Multivariate analysis revealed a correlation between high white blood cell (WBC) count, ascites, preterm delivery, bleeding diatheses, failure of spontaneous remission, and the occurrence of early death. Treatment with cytarabine (0.5-1.5 mg/kg) was administered to 28 patients with high WBC count, thrombocytopenia, or liver dysfunction. The therapy had a beneficial effect on the outcome of those children with risk factors for early death (5-year EFS, 52% +/- 12% vs 28% +/- 11% [no treatment]; P = .02). Multivariate analysis demonstrated its favorable prognostic impact. A total of 29 (23%) patients with TL subsequently developed ML-DS. Patients with ML-DS with a history of TL had a significantly better 5-year EFS (91% +/- 5%) than those without documented TL (70% +/- 4%), primarily due to a lower relapse rate. A history of TL may therefore define a lower-risk ML-DS subgroup. This study was registered at www.clinicaltrials. gov as no. NCT 00111345.