Miracle-dz/UniFAR-FTUs huggingface dataset:
The ulcerative colitis marker protein WAFL interacts with accessory proteins in endocytosis

Ulcerative colitis (UC) is one of the major forms of inflammatory bowel disease with unknown cause. A molecular marker, WAFL, has recently been found to be up-regulated in the inflamed colonic mucosa of UC patients. Towards understanding biological function of WAFL, we analyzed proteins interacting with WAFL in HEK-293 cells by immunoprecipitation and mass spectrometry. Among four proteins found to specifically interact with WAFL, both KIAA0196 and KIAA1033 bind to α-appendage of the adaptor protein complex 2 (AP2), which acts as an interaction hub for accessory proteins in endocytosis mediated by clathrin-coated vesicle (CCV). The specific interaction between WAFL and KIAA0196 was also confirmed in human colorectal carcinoma HCT-116 cells by co-immunoprecipitation with specific antibodies. Meta-analyses of the databases of expressed genes suggest that the three genes are co-expressed in many tissues and cell types, and that their molecular function may be classified in the category of 'membrane traffic protein'. Therefore, these results suggest that WAFL may play an important role in endocytosis and subsequent membrane trafficking by interacting with AP2 through KIAA0196 and KIAA1033.
Distributed Cloud Bursting Model Based on Peer-to-Peer Overlay

In this paper, we present an approach to building cloud bursting architecture based on the peer-to-peer infrastructure for managing services. Proposed approach is designed to address various issues of interconnecting several clouds, problems of resource provisioning, service deployment and provisioning in the hybrid cloud. To ensure robustness of our system we use peer-to-peer overlay, which was proposed by us in previous papers. Scalability of the approach is attained due to flexibility of service discovery mechanism, decentralized architecture and modular approach, which allows to leverage existing components. We argue that our approach present viable solution for managing abrupt peaks in the load and keeping service provider's QoS and SLA requirements on the desired level.
Minimum Cost Routing with a Lifetime Guarantee in Wireless Sensor Networks

In this paper, we focus on minimum cost routing in the Wireless Sensor Networks (WSNs). In-network data is often routed in such a way that it can minimize overall energy consumption or it can maximize the network lifetime. However, these metrics do not take into account other costs such as queueing delay and congestion. We solve the problem by introducing a comprehensive cost function and formulating the problem as minimizing the overall cost with a lifetime guarantee. We demonstrate the convexity of the problem and introduce Lagrangian Duality method to decompose the problem. A gradient projection based algorithm is proposed to solve the problem in a fully distributed way. The convergence of the algorithm is verified theoretically. We show through extensive numerical results that our proposed algorithm converges quickly to the optimal solution, and that our algorithm has a better performance than existing algorithms.
Practical Considerations in Training Extreme Learning Machines

Extreme learning machines (ELM) represent a new fast learning algorithm for single layer feedforward networks. In this paper, we investigate several practical properties of training ELM in the context of a simulated function approximation task. ELM with different hidden layer activation functions and varying number of hidden nodes are applied in the learning task and the function approximation accuracy is examined with respect to the range scaling of input variables. The results demonstrate that ELM models are very sensitive with respect to proper input scaling. The approximate range of optimal ELM performance covers only input range scaling within an order of magnitude. Comparison with classical feedforward neural networks with sigmoidal activation functions shows that these are not affected by input range scaling. Results encourage further studies of practical aspect of efficient training and applying ELM.
Aging modulates cuticular hydrocarbons and sexual attractiveness in Drosophila melanogaster

SUMMARY Attractiveness is a major component of sexual selection that is dependent on sexual characteristics, such as pheromone production, which often reflect an individual’s fitness and reproductive potential. Aging is a process that results in a steady decline in survival and reproductive output, yet little is known about its effect on specific aspects of attractiveness. In this report we asked how aging impacts pheromone production and sexual attractiveness in Drosophila melanogaster. Evidence suggests that key pheromones in Drosophila are produced as cuticular hydrocarbons (CHC), whose functions in attracting mates and influencing behavior have been widely studied. We employed gas chromatography/mass spectrometry and laser desorption/ionization mass spectrometry to show that the composition of D. melanogaster CHC is significantly affected by aging in both sexes and that these changes are robust to different genetic backgrounds. Aging affected the relative levels of many individual CHC, and it shifted overall hydrocarbon profiles to favor compounds with longer chain lengths. We also show that the observed aging-related changes in CHC profiles are responsible for a significant reduction in sexual attractiveness. These studies illuminate causal links among pheromones, aging and attractiveness and suggest that CHC production may be an honest indicator of animal health and fertility.
Effects of matrix macromolecules on chondrocyte gene expression: synthesis of a low molecular weight collagen species by cells cultured within collagen gels

Chick-embryo sternal chondrocytes have been cultured within three- dimensional collagen gels as part of a study concerned with the effects of extracellular matrix macromolecules on chondrocyte gene expression. Data are presented indicating that chondrocytes cultured within such a collagenous environment synthesize significantly more of an hitherto unidentified, low molecular weight collagen species than do cells grown on plastic tissue-culture dishes in the conventional manner. This low molecular weight collagen species contains noncollagenous domains (as indicated by its decreased molecular size after mild pepsin digestion), is distinct from the known collagen types (as judged by CNBr peptide analysis), and forms part of the insoluble collagenous matrix produced by the chondrocytes. Cells growing within the gel tend to form colonies consisting of a linear array of cells reminiscent of the cellular organization in growth cartilage.
Psychometric Evaluation of the German Version of the Perceived Access to Healthcare Questionnaire in a Sample of Individuals with Rare Chronic Diseases

Access to healthcare is multifaceted and poses significant challenges for individuals with chronic and rare diseases (RDs). This study aimed to conduct a psychometric evaluation of the German version of the Perception of Access to Healthcare Questionnaire (PAHQ) among individuals with RDs. We conducted an evaluation of the PAHQ using a sample of 271 adults with an RD diagnosis. The 31-item instrument underwent evaluation including a comparison of three different confirmatory factor models (CFA). Subsequent steps involved item removal, reliability analysis (computation of Cronbach’s alpha), and analysis of criterion-related validity. The six-factor model showed the best fit to the data and was selected for further examination. Subsequently, six items were removed. Fit indices for the final model were acceptable. Cronbach’s alpha ranged from 0.75 to 0.91 for the six subscales, except for the availability subscale which exhibited the lowest value (0.64). In terms of criterion-related validity, different skills relating to the navigation of access dimensions were significantly correlated with corresponding PAHQ subscales, thus confirming validity. The capacity of the PAHQ to guide targeted interventions and facilitate cross-population comparisons positions it as a valuable instrument for advancing healthcare access research and promoting equitable access to care, particularly for individuals with rare and chronic diseases.
Stacking designs: designing multi-ﬁdelity experiments with target predictive accuracy ∗

In an era where scientiﬁc experiments can be very costly, multi-ﬁdelity emulators provide a useful tool for cost-eﬃcient predictive scientiﬁc computing. For scientiﬁc applications, the experimenter is often limited by a tight computational budget, and thus wishes to (i) maximize predictive power of the multi-ﬁdelity emulator via a careful design of experiments, and (ii) ensure this model achieves a desired error tolerance with some notion of conﬁdence. Existing design methods, however, do not jointly tackle objectives (i) and (ii). We propose a novel stacking design approach that addresses both goals. Using a recently proposed multi-level Gaussian process emulator model, our stacking design provides a sequential approach for designing multi-ﬁdelity runs such that a desired prediction error of (cid:15) > 0 is met under regularity assumptions. We then prove a novel cost complexity theorem that, under this multi-level Gaussian process emulator, establishes a bound on the computation cost (for training data simulation) needed to achieve a prediction bound of (cid:15) . This result provides novel insights on conditions under which the proposed multi-ﬁdelity approach improves upon a standard Gaussian process emulator which relies on a single ﬁdelity level. Finally, we demonstrate the eﬀectiveness of stacking designs in a suite of simulation experiments and an application to ﬁnite element analysis.
Damaris/Viz: A nonintrusive, adaptable and user-friendly in situ visualization framework

Reducing the amount of data stored by simulations will be of utmost importance for the next generation of large-scale computing. Accordingly, there is active research to shift analysis and visualization tasks to run in situ, that is, closer to the simulation via the sharing of some resources. This is beneficial as it can avoid the necessity of storing large amounts of data for post-processing. In this paper, we focus on the specific case of in situ visualization where analysis codes are collocated with the simulation's code and run on the same resources. It is important for an in situ technique to require minimum modifications to existing codes, be adaptable, and have a low impact on both run times and resource usage. We accomplish this through the Damaris/Viz framework, which provides in situ visualization support to the Damaris I/O middleware. The use of Damaris as a bridge to existing visualization packages allows us to (1) reduce code moditication to a minimum for existing simulations, (2) gather capabilities of several visualization tools to offer a unified data management interface, (3) use dedicated cores to hide the run time impact of in situ visualization and (4) efficiently use memory through a shared-memory-based communication model. Experiments are conducted on Blue Waters and Grid'5000 to visualize the CM1 atmospheric simulation and the Nek5000 CFD solver.
Ultra-step-up DC-DC converter with integrated autotransformer and coupled inductor

This paper introduces a new single-switch nonisolated dc-dc converter with very high voltage transfer ratio and reduced semiconductor voltage stress. The converter utilizes an integrated autotransformer and a coupled inductor on the same core to achieve a high step-up voltage gain without extreme duty cycle. Further, an integrated passive regenerative circuit recycles the leakage energy of the coupled magnetics and transfer the leakage energy to the load, which helps to avoid high voltage spikes across the switch. This feature along with low stress on the switching device enables the designer to use a low voltage and low RDS-on MOSFET, which reduces the cost, and also the conduction and turn on losses of the switch. The principle of operation and theoretical analysis supported by key simulation and experimental waveforms are presented in details.
High-frequency ultrasound Doppler detection using fundamental pulse inversion technique

Swept-scan imaging mode is often utilized in high-frequency ultrasound Doppler estimation of blood flow. However, tissue spectral broadening effect in swept-scan system severely limits the detection of low-velocity flow especially at high scanning speed of motor. To alleviate the effect of wall filtering on low-velocity blood signal, the suppression of tissue Doppler signal using micro-bubble contrast agent and non-linear imaging can be helpful. With the method of fundamental pulse-inversion Doppler (FPID), the non-linear bubble signal can be isolated from the linear tissue signal at fundamental frequency by low-pass filtering in the Doppler domain to reduce the clutter interference. Results show that the FPID helps to retain the low-velocity blood flow signal in color Doppler imaging and thus improves the efficacy of blood flow detection. With different lateral scanning speed of motor (Vmotor), the values of color-pixel density (CPD) with FPID are 0.63 (Vmotor = 4mm/s), 0.65 (Vmotor = 8mm/s) and 0.58 (Vmotor = 16mm/s). It shows that FPID is less susceptible to the tissue spectral broadening effect The results also show that, with FPID method, the flow signal-to-clutter ratio (SCR) increases by 7.7dB (P <; 0.001) and the CPD increases by 20 % (P <; 0.001) in the case of 3mm/s of blood flow velocity and 16mm/s lateral scanning speed of motor.
Arytenoid dislocation with lighted stylet intubation: case report and retrospective review.

he use of the lighted stylet for transtracheal illumination to facilitate blind endotracheal inT tubations was first described in 1959 (1). The usefulness of this technique in cases of difficult intubation has been established (2,3). The complications reported are few, and have included a single case report of cricoarytenoid dislocation (4) and another of nonspecific tissue trauma (2). We report a second case of arytenoid dislocation associated with a lighted stylet intubation and the results of our experience with 1131 lighted stylet intubations over a 3-yr period.
Emergency Administration of Abciximab for Treatment of Patients With Acute Ischemic Stroke: Results of a Randomized Phase 2 Trial

Background and Purpose— Because of its success in treatment of acute cardiac ischemia, there is interest in the use of abciximab for treating patients with acute ischemic stroke. A previous dose-escalation study determined that abciximab could be given safely in a regimen of 0.25 mg/kg intravenous bolus followed by a 12-hour infusion at 0.125 &mgr;g/kg per minute (maximum 10 &mgr;g/min). This study was performed to obtain more information about the safety and potential efficacy of abciximab in patients with stroke. Methods— An international randomized, double-blind, placebo-controlled phase 2 trial enrolled 400 patients within 6 hours of onset of ischemic stroke. The primary safety outcome was the rate of symptomatic hemorrhage that occurred during the first 5 days after stroke. The primary efficacy measure was the distribution of outcomes at 3 months after stroke using the modified Rankin Scale (mRS) based on an ordinal regression model of outcomes, adjusting for baseline severity of stroke, age, and interval from stroke. Results— Symptomatic intracranial hemorrhage within 5 days was diagnosed in 7 of 195 (3.6%) patients treated with abciximab and 2 of 199 (1%) patients given placebo (odds ratio [OR], 3.7; P=0.09; 95% confidence interval [CI], 0.7 to 25.9). Asymptomatic hemorrhagic transformation was detected by brain imaging in 24 patients administered abciximab and 33 patients receiving placebo (OR, 0.74; P=0.25; 95% CI, 0.4 to 1.3). Treatment with abciximab showed a nonsignificant shift in favorable outcomes as measured by mRS scores at 3 months (OR, 1.20; P=0.33; 95% CI, 0.84 to 1.70). Conclusions— Intravenously administered abciximab can be given to patients with a reasonable degree of safety. The trial also suggests that abciximab could improve outcomes at 3 months after stroke. A larger randomized, double-blind, placebo-controlled trial is necessary to test the efficacy of abciximab.
Tardive dyskinesia.

Neuroleptic-induced tardive dyskinesia (TD) continues to be a serious problem in the psychopharmacology of schizophrenia. The overall mean prevalence of TD among chronically neuroleptic-treated patients is approximately 24 percent. The annual incidence in younger adults is 4 to 5 percent. Aging is a major risk factor for TD. Our ongoing prospective study suggests that the annual incidence in patients over age 45 is over 30 percent. Other likely risk factors include female gender, mood disorders, "organic" brain dysfunction or damage, diabetes mellitus, and early extrapyramidal side effects. Metoclopramide, a D2-receptor blocker commonly used in non-psychiatric medical patients, can also produce persistent TD. TD can best be assessed for research purposes by a combination of subjective and objective methods. In recent years, several instrumental procedures have been developed to objectively quantify various abnormal movements. The advantages and limitations of the traditional rating scales and the newer instrumental approaches are discussed. The course of TD is variable but often not progressive. The early theory that striatal dopamine receptor supersensitivity causes TD has now given way to the hypothesis of multiple neurotransmitter system involvement. Several animal studies have reported striatal neuronal damage with prolonged neuroleptic treatment, although its relevance to TD remains unclear. Treatments for TD, other than neuroleptic withdrawal, are still experimental.
The metabolic coregulator RIP 140 : an update

Fritah A, Christian M, Parker MG. The metabolic coregulator RIP140: an update. Am J Physiol Endocrinol Metab 299: E335–E340, 2010. First published June 8, 2010; doi:10.1152/ajpendo.00243. 2010. —RIP140 is a transcriptional coregulator highly expressed in metabolic tissues where it has important and diverse actions. RIP140-null mice show that it plays a crucial role in the control of lipid metabolism in adipose tissue, skeletal muscle, and the liver and is essential for female fertility. RIP140 has been shown to act as a ligand-dependent transcriptional corepressor for metabolic nuclear receptors such as estrogen-related receptors and peroxisome proliferator-activated receptors. The role of RIP140 as a corepressor has been strengthened by the characterization of RIP140-overexpressing mice, although it emerges through several studies that RIP140 can also behave as a coactivator. Nuclear localization of RIP140 is important for controlling transcription of target genes and is subject to regulation by posttranslational modifications. However, cytoplasmic RIP140 has been shown to play a role in the control of metabolism through direct regulation of glucose transport in adipocytes. In this review, we focus on recent advances highlighting the growing importance of RIP140 as a regulator of energy homeostasis.
HOSPITAL FOOD SERVICE ASSESSMENT IMPROVING NUTRITIONAL INTAKE INPATIENTS: A LITERATURE REVIEW

Background: Malnutrition in hospitals is a commonly occurring and often overlooked issue that impacts not only the clinical outcomes of patients, such as their length of stay, morbidity, mortality, and quality of life, but also the overall sustainability of the healthcare system. column format. Aims: The purpose of writing this systematic literature review is to collect scientific evidence regarding food service satisfaction assessment techniques for inpatients in hospitals. Method: This research conducting a literature review using PRISMA guidelines, using data based on Google Scholar and Scopus which examined the level of patient satisfaction with food services in hospitals. Result: From the six papers that we analyzed, we obtained an assessment process for the level of patient satisfaction using caloric intake calculations, and some used validated questionnaires, and obtained several appropriate strategies to increase the nutritional intake of inpatients. Conclusions: Assessing the patient's nutritional and nutritional intake is very important in determining the patient's health and recovery.
A Multifunctional Mannosyltransferase Family in Candida albicans Determines Cell Wall Mannan Structure and Host-Fungus Interactions

The cell wall proteins of fungi are modified by N- and O-linked mannosylation and phosphomannosylation, resulting in changes to the physical and immunological properties of the cell. Glycosylation of cell wall proteins involves the activities of families of endoplasmic reticulum and Golgi-located glycosyl transferases whose activities are difficult to infer through bioinformatics. The Candida albicans MNT1/KRE2 mannosyl transferase family is represented by five members. We showed previously that Mnt1 and Mnt2 are involved in O-linked mannosylation and are required for virulence. Here, the role of C. albicans MNT3, MNT4, and MNT5 was determined by generating single and multiple MnTΔ null mutants and by functional complementation experiments in Saccharomyces cerevisiae. CaMnt3, CaMnt4, and CaMnt5 did not participate in O-linked mannosylation, but CaMnt3 and CaMnt5 had redundant activities in phosphomannosylation and were responsible for attachment of approximately half of the phosphomannan attached to N-linked mannans. CaMnt4 and CaMnt5 participated in N-mannan branching. Deletion of CaMNT3, CaMNT4, and CaMNT5 affected the growth rate and virulence of C. albicans, affected the recognition of the yeast by human monocytes and cytokine stimulation, and led to increased cell wall chitin content and exposure of β-glucan at the cell wall surface. Therefore, the MNT1/KRE2 gene family participates in three types of protein mannosylation in C. albicans, and these modifications play vital roles in fungal cell wall structure and cell surface recognition by the innate immune system.
Iterative Linear Quadratic Regulator Design for Nonlinear Biological Movement Systems

This paper presents an Iterative Linear Quadratic Regulator (ILQR) method for locally-optimal feedback control of nonlinear dynamical systems. The method is applied to a musculo-skeletal arm model with 10 state dimensions and 6 controls, and is used to compute energy-optimal reaching movements. Numerical comparisons with three existing methods demonstrate that the new method converges substantially faster and finds slightly better solutions.
Issues Surrounding the Rice Price of Thailand from 2003 to 2013

Thailand is always one of the top export rice in the word. During the year 2003 to 2013, there were many issues that affected the rice price of Thailand. So that, rice production in Thailand used to have a lot differentiations in Arable Land, Rice Area, Paddy Yield, Paddy Production, Milled Production, Rice Imports, Rice Exports, etc. In this research paper, there will be some evaluation about rice productions of Thailand between 10 years from 2003 to 2013. While analyzing elasticity of rice price between Vietnam and Thailand which white rice is the main objective, the researchers find out that white rice in both countries is inelasticity product which means it is very popular and few subtitles. These comparisons will help audiences have general views about Thailand rice production during this period of time; and look at advantages and disadvantages when comparing to the neighbor country is Vietnam. Finally, with those realistic assessments, this research paper contributes another view about rice – the most important crop of Thailand.