Miracle-dz/UniFAR-FTUs huggingface dataset:
A 5-year follow-up of general practice patients experiencing depression.

BACKGROUND Depression is a common disease in primary care and produces significant morbidity in the community. Little is known about the outcomes of depression in general practice. OBJECTIVES This research set out to explore both the longitudinal management and outcomes of depression as seen in general practice. METHODS The Medic-GP database is a collection of the medical records of >50 000 people seen in nine Australian general practices. It was used to follow the management of depressed patients over 4-5 years. Records from 1994-1995 were searched for depression or similar words. Individual records of patients whose notes mentioned depression were randomly selected and examined to determine if they were diagnosed with depression. Records of patients who were diagnosed as suffering from depression were examined to determine progress over the ensuing 5 years. RESULTS Six hundred of 5889 patients were examined in detail. A total of 382 patients (63.7%) were diagnosed with depression; 219 had been diagnosed during this time interval. The main findings were 64.7% of patients were female; 93.6% of patients received an antidepressant at some time during the study; 16% of patients were referred to a psychiatrist; 7.3% were hospitalized; 30% of patients who ceased antidepressants without a recurrence had courses of antidepressants of 3 months or less; and only 22.5% of patients had a single episode of depression. CONCLUSION Unlike cross-sectional studies, this study has shown a high rate of prescription of antidepressants. GPs often prescribed short courses of antidepressants, and depression behaves as a chronic, recurrent disease.
Towards better integration of performing and managing the information systems development

In this paper we discuss one relatively hidden but important issue related to information systems development - weak integration of performing and managing the information systems development. Among others, two causes for such weak integration are identified as important-weak integration of methodological support to the performing and managing the development, and difficulties in knowledge transfer. We show that in practice this may have some important adverse consequences for development process, such as communication problems between engineering and managerial parts of the development team, or insisting on application of inappropriate method. In this paper we argue that the methodological integration is, rather than methodological innovation, a potential solution to this problem - both processes have traditionally quite well developed methodological support but the essential interconnection of these methods is often missing. As another potential improvement primarily intended to facilitate knowledge transfer within development team, we also suggest stronger integration of knowledge that the development process managers should possess.
Movement of Soil-Applied Imidacloprid and Thiamethoxam into Nectar and Pollen of Squash (Cucurbita pepo)

There has been recent interest in the threat to bees posed by the use of systemic insecticides. One concern is that systemic insecticides may translocate from the soil into pollen and nectar of plants, where they would be ingested by pollinators. This paper reports on the movement of two such systemic neonicotinoid insecticides, imidacloprid and thiamethoxam, into the pollen and nectar of flowers of squash (Cucurbita pepo cultivars “Multipik,” “Sunray” and “Bush Delicata”) when applied to soil by two methods: (1) sprayed into soil before seeding, or (2) applied through drip irrigation in a single treatment after transplant. All insecticide treatments were within labeled rates for these compounds. Pollen and nectar samples were analyzed using a standard extraction method widely used for pesticides (QuEChERS) and liquid chromatography mass spectrometric analysis. The concentrations found in nectar, 10±3 ppb (mean ± s.d) for imidacloprid and 11±6 ppb for thiamethoxam, are higher than concentrations of neonicotinoid insecticides in nectar of canola and sunflower grown from treated seed, and similar to those found in a recent study of neonicotinoids applied to pumpkins at transplant and through drip irrigation. The concentrations in pollen, 14±8 ppb for imidacloprid and 12±9 ppb for thiamethoxam, are higher than those found for seed treatments in most studies, but at the low end of the range found in the pumpkin study. Our concentrations fall into the range being investigated for sublethal effects on honey bees and bumble bees.
Nebulized and oral thiol derivatives for pulmonary disease in cystic fibrosis.

BACKGROUND Cystic fibrosis is an inherited condition resulting in thickened, sticky respiratory secretions. Respiratory failure, due to recurrent pulmonary infection and inflammation, is the most common cause of mortality. Muco-active therapies (e.g. dornase alfa and nebulized hypertonic saline) may decrease sputum viscosity, increase airway clearance of sputum, reduce infection and inflammation and improve lung function. Thiol derivatives, either oral or nebulized, have shown benefit in other respiratory diseases. Their mode of action is likely to differ according to the route of administration. There are several thiol derivatives, and it is unclear which of these may be beneficial in cystic fibrosis. OBJECTIVES To evaluate the efficacy and safety of nebulized and oral thiol derivatives in people with cystic fibrosis. SEARCH STRATEGY We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register, comprising references identified from comprehensive electronic database searches, hand searches of relevant journals, abstract books and conference proceedings.Most recent search: November 2008. SELECTION CRITERIA Randomized and quasi-randomized controlled trials comparing nebulized or oral thiol derivatives to placebo or another thiol derivative in people with cystic fibrosis. DATA COLLECTION AND ANALYSIS The authors independently assessed trials for inclusion, analysed methodological quality and extracted data. MAIN RESULTS Searches identified 18 trials; eight (seven older than 10 years) (234 participants) are included. Three trials of nebulized thiol derivatives were identified (one compared 20% n-acetylcysteine to 2% n-acetylcysteine; another compared sodium-2-mercaptoethane sulphonate to 7% hypertonic saline; and another compared glutathione to 4% hypertonic saline). Although generally well-tolerated with no significant adverse effects, there was no evidence of significant clinical benefit in our primary outcomes in participants receiving these treatments.Five studies of oral thiol derivatives were identified. Three studies compared n-acetylcysteine to placebo; one compared n-acetylcysteine, ambroxol and placebo; and one compared carbocysteine to ambroxol. Oral thiol derivatives were generally well-tolerated with no significant adverse effects, however there was no evidence of significant clinical benefit in our primary outcomes in participants receiving these treatments. AUTHORS' CONCLUSIONS We found no evidence to recommend the use of either nebulized or oral thiol derivatives in people with cystic fibrosis. There are very few good quality trials investigating the effect of these medications in cystic fibrosis, and further research is required to investigate the potential role of these medications in improving the outcomes of people with cystic fibrosis.
Image transmissions with security enhancement based on region and path diversity in wireless sensor networks

Transmissions of large sized images can be a bottleneck for a wireless sensor network (WSN) due to its limited resources. Security can be another concern. This paper proposes a collaborative transmission scheme for image sensors to utilize inter-sensor correlations to decide the transmission and security sharing patterns based on the path diversities. Our proposed approach for secret image sharing on multiple node-disjoint paths for image delivery is to achieve high security without any key distribution and management, and thus the key management related problems do not exist. The energy efficiency is another major contribution made in this paper. This scheme does not only allow each image sensor to transmit optimal fractions of overlapped images through appropriate transmission paths in an energy-efficient way, but also provides unequal protection to overlapped image regions by path selections and adaptive bit error rate (BER) requirement. The simulation results show that the proposed scheme can achieve considerable gains in terms of network lifetime extension, image transmission security enhancement, image quality improvement, and energy efficiency for wireless sensor networks.
A potential reduction algorithm for two-person zero-sum limiting average payoff stochastic games

We suggest a new algorithm for two-person zero-sum undiscounted stochastic games focusing on stationary strategies. Given a positive real , let us call a stochastic game -ergodic, if its values from any two initial points differ by at most . The proposed new algorithm outputs for every > 0 in finite time either a pair of stationary strategies for the two players guaranteeing that the values from any initial points are within an range, or identifies two initial points u and v and corresponding stationary strategies for the players proving that the game values starting from u and v are at least /24 apart. In particular, the above result shows that if a stochastic game is -ergodic, then there are stationary strategies for the players proving 24 -ergodicity. This result strengthens a result by Vrieze (1980) claiming that if a stochastic game is 0-ergodic, then there are -optimal stationary strategies for every > 0. The suggested algorithm extends the approach recently introduced for stochastic games with perfect information, and is based on the classical potential transformation technique that changes the range of local values at all positions without changing the normal form of the game. Acknowledgements: This research was partially supported by DIMACS, Center for Discrete Mathematics and Theoretical Computer Science, Rutgers University, and by the Scientific Grant-in-Aid from Ministry of Education, Science, Sports and Culture of Japan. Part of this research was done at the Mathematisches Forschungsinstitut Oberwolfach during a stay within the Research in Pairs Program from March 7 to March 20, 2010. The first author also acknowledges the partial support of NSF Grant IIS-0803444 and NSF Grant CMMI-0856663.
The Arabidopsis PR-1 Promoter Contains Multiple Integration Sites for the Coactivator NPR1 and the Repressor SNI1[W]

Systemic acquired resistance is a broad-spectrum plant immune response involving massive transcriptional reprogramming. The Arabidopsis (Arabidopsis thaliana) PATHOGENESIS-RELATED-1 (PR-1) gene has been used in numerous studies to elucidate transcriptional control mechanisms regulating systemic acquired resistance. WRKY transcription factors and basic leucine zipper proteins of the TGA family regulate the PR-1 promoter by binding to specific cis-elements. In addition, the promoter is under the control of two proteins that do not directly contact the DNA: the positive regulator NONEXPRESSOR OF PR GENES1 (NPR1), which physically interacts with TGA factors, and the repressor SUPPRESSOR OF NPR1, INDUCIBLE1 (SNI1). In this study, we analyzed the importance of the TGA-binding sites LS5 and LS7 and the WKRY box LS4 for regulation by NPR1 and SNI1. In the absence of LS5 and LS7, NPR1 activates the PR-1 promoter through a mechanism that requires LS4. Since transcriptional activation of WRKY genes is under the control of NPR1 and since LS4 is not sufficient for the activation of a truncated PR-1 promoter by the effector protein NPR1-VP16 in transient assays, it is concluded that the LS4-dependent activation of the PR-1 promoter is indirect. In the case of NPR1 acting directly through TGA factors at its target promoters, two TGA-binding sites are necessary but not sufficient for NPR1 function in transgenic plants and in the NPR-VP16-based trans-activation assay in protoplasts. SNI1 exerts its negative effect in the noninduced state by targeting unknown proteins associated with sequences between bp −816 and −573. Under induced conditions, SNI1 negatively regulates the function of WRKY transcription factors binding to WKRY boxes between bp −550 and −510.
R-PEAK DETECTION USING WAVELET TRANSFORMS TECHNIQUE

This paper presents a technique based on wavelet transforms to analyze the electrocardiogram signal (ECG) for the detection of the R peaks. We locate the QRS complexes of this signal using the dyadic wavelet transform (DyWT) and detect the R peaks using the direction change mark method (DCM). Applied on the ECG signal database MIT-BIH, the algorithm that we present gave good results for detecting the R waves with a rate of 99.91%, a sensitivity of 99.95 % and a positive predictivity of 99.96 %.
Kinesin is the motor for microtubule-mediated Golgi-to-ER membrane traffic [published errata appear in J Cell Biol 1995 Mar;128(5):following 988 and 1995 May;129(3):893]

The distribution and dynamics of both the ER and Golgi complex in animal cells are known to be dependent on microtubules; in many cell types the ER extends toward the plus ends of microtubules at the cell periphery and the Golgi clusters at the minus ends of microtubules near the centrosome. In this study we provide evidence that the microtubule motor, kinesin, is present on membranes cycling between the ER and Golgi and powers peripherally directed movements of membrane within this system. Immunolocalization of kinesin at both the light and electron microscopy levels in NRK cells using the H1 monoclonal antibody to kinesin heavy chain, revealed kinesin to be associated with all membranes of the ER/Golgi system. At steady-state at 37 degrees C, however, kinesin was most concentrated on peripherally distributed, pre- Golgi structures containing beta COP and vesicular stomatitis virus glycoprotein newly released from the ER. Upon temperature reduction or nocodazole treatment, kinesin's distribution shifted onto the Golgi, while with brefeldin A (BFA)-treatment, kinesin could be found in both Golgi-derived tubules and in the ER. This suggested that kinesin associates with membranes that constitutively cycle between the ER and Golgi. Kinesin's role on these membranes was examined by microinjecting kinesin antibody. Golgi-to-ER but not ER-to-Golgi membrane transport was found to be inhibited by the microinjected anti-kinesin, suggesting kinesin powers the microtubule plus end-directed recycling of membrane to the ER, and remains inactive on pre-Golgi intermediates that move toward the Golgi complex.
Cultural Humility Versus Cultural Competence: A Critical Distinction in Defining Physician Training Outcomes in Multicultural Education

Researchers and program developers in medical education presently face the challenge of implementing and evaluating curricula that teach medical students and house staff how to effectively and respectfully deliver health care to the increasingly diverse populations of the United States. Inherent in this challenge is clearly defining educational and training outcomes consistent with this imperative. The traditional notion of competence in clinical training as a detached mastery of a theoretically finite body of knowledge may not be appropriate for this area of physician education. Cultural humility is proposed as a more suitable goal in multicultural medical education. Cultural humility incorporates a lifelong commitment to self-evaluation and self-critique, to redressing the power imbalances in the patient-physician dynamic, and to developing mutually beneficial and nonpaternalistic clinical and advocacy partnerships with communities on behalf of individuals and defined populations.
The LBP Integrating Neighbor Pixels on Face Recognition

The traditional LBP only considers the difference between the center pixel and the neighbor pixels. In order to use the relationship of the center pixel and neighbor pixels, a manipulative texture method B_LBP is proposed in this paper, which integrates the grayscale intensity of neighbor pixels into traditional LBP. The method keeps the local structure information of original images and enhances the identification ability. LDA (Linear discriminate analysis) is used to reduce the dimensionality of the original data. The experiments are conducted on Yale B and CMU PIE face databases with B_LBP, LEP and LBP. The results show that the B_LBP is superior to the traditional LBP and LEP.
ASYMPTOTIC ANALYSIS OF OSCILLATORY INTEGRALS WITH SMOOTH WEIGHTS

We announce some results obtained in [16], which is a joint work with Kamimoto, on the asymptotic behavior of oscillatory integrals with smooth weights. Our results show that the optimal rates of decay for weighted oscillatory integrals, whose phases and weights are contained in a certain class of smooth functions including the real analytic class, can be expressed by the Newton distance and multiplicity defined in terms of geometrical relationship of the Newton polyhedra of the phase and the weight.
Lovastatin induced Kruppel like factor 2 (KLF2), Kruppel like factor 6 (KLF6) and Ras homolog family member B (RHOB) genes and preferentially led to viability reduction of Cisplatin-resistant cells

It was reported that statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase that are used to prevent hypercholesterolemia, have antitumor activity in several cancers. In this study, we investigated the cell viability of statins in Cisplatin-resistant HCP4 and PCDP5 cells compared with their parent Hela and PC3 cells, respectively, and found that HCP4 and PCDP5 cells were 37-fold and 18-fold more resistant to Cisplatin but 13-fold and 7-fold more sensitive to Lovastatin by cell proliferation assay. Lovastatin induced the apoptosis of HCP4 cells more rapidly and to greater extent than in Hela cells as assessed by flow cytometry and western blotting analyses. The MVA pathway was not involved in this acquired Cisplatin resistance. To elucidate the mechanism underlying the reduced viability to Lovastatin, we performed cDNA microarray analysis and identified 65 and 54 genes that were induced more than 2-fold by Lovastatin in HCP4 and PCDP5 cells, respectively. Of these, only three genes, KLF2, KLF6, and RHOB, were commonly induced between HCP4 and PCDP5 cells. These mRNAs were strongly induced by Lovastatin with transcriptional regulation in HCP4 cells. Consistent with transcription, the protein expression of RHOB also was induced by Lovastatin. The induction of these genes was associated with cell cycle arrest and apoptosis. Combination treatment with Cisplatin and Lovastatin resulted in an agonistic effect in Hela and PC3 cells and an antagonistic effect in HCP4 and PCDP5 cells. These results suggest that statins might have the potential to overcome Cisplatin resistance as single-agent therapy.
The “Djedi” Robot Exploration of the Southern Shaft of the Queen's Chamber in the Great Pyramid of Giza, Egypt

There are many unanswered questions regarding the construction and purpose of the Great Pyramid of Giza, Egypt. A climbing robot called “Djedi” has been designed, constructed, and deployed to explore shafts of the queen's chamber within the Great Pyramid. The Djedi robot is based on the concept of inchworm motion and is capable of carrying a long reach drill or snake camera. The robot successfully climbed the southern shaft of the Great Pyramid, deployed its snake camera, and revealed writing not seen for thousands of years. This paper details the design of the robot, including climbing steps in the shaft and lessons learned from experimental deployment. © 2013 Wiley Periodicals, Inc.
Absence of p75NTR Causes Increased Basal Forebrain Cholinergic Neuron Size, Choline Acetyltransferase Activity, and Target Innervation

Emerging evidence suggests that the p75 neurotrophin receptor (p75NTR) mediates cell death; however, it is not known whether p75NTR negatively regulates other neuronal phenotypes. We found that mice null for p75NTR displayed highly significant increases in the size of basal forebrain cholinergic neurons, including those that are TrkA-positive. Cholinergic hippocampal target innervation also was increased significantly. Activity of the cholinergic neurotransmitter synthetic enzyme choline acetyltransferase (ChAT) was increased in both the medial septum and hippocampus. Upregulation of these cholinergic features was not associated with increased basal forebrain or hippocampal target NGF levels. In contrast, striatal cholinergic neurons, which do not express p75NTR, showed no difference in neuronal number, size, or ChAT activity between wild-type and p75NTR null mutant mice. These findings indicate that p75NTR negatively regulates cholinergic neuronal phenotype of the basal forebrain cholinergic neurons, including cell size, target innervation, and neurotransmitter synthesis.
BAH1/NLA, a RING-Type Ubiquitin E3 Ligase, Regulates the Accumulation of Salicylic Acid and Immune Responses to Pseudomonas syringae DC30001[W][OA]

Salicylic acid (SA) is a primary factor responsible for exerting diverse immune responses in plants and is synthesized in response to attack by a wide range of pathogens. The Arabidopsis (Arabidopsis thaliana) sid2 mutant is defective in a SA biosynthetic pathway involving ISOCHORISMATE SYNTHASE1 (ICS1) and consequently contains reduced levels of SA. However, the sid2 mutant as well as ICS-suppressed tobacco (Nicotiana benthamiana) still accumulate a small but significant level of SA. These observations along with previous studies suggest that SA might also be synthesized by another pathway involving benzoic acid (BA). Here we isolated a benzoic acid hypersensitive1-Dominant (bah1-D) mutant that excessively accumulated SA after application of BA from activation-tagged lines. This mutant also accumulated higher levels of SA after inoculation with Pseudomonas syringae pv tomato DC3000. Analysis of the bah1-D sid2 double mutant suggested that the bah1-D mutation caused both ICS1-dependent and -independent accumulation. In addition, the bah1-D mutant showed SA-dependent localized cell death in response to P. syringae pv tomato DC3000. The T-DNA insertional mutation that caused the bah1-D phenotypes resulted in the suppression of expression of the NLA gene, which encodes a RING-type ubiquitin E3 ligase. These results suggest that BAH1/NLA plays crucial roles in the ubiquitination-mediated regulation of immune responses, including BA- and pathogen-induced SA accumulation, and control of cell death.
Five-beam holographic fabrication of 3D photonic crystal templates using a single diffractive optical element

In this paper we demonstrate an approach for laser holographic manufacturing of three-dimensional photonic lattice structures using a single specially designed, diffraction optical element mask. The mask is fabricated by recording gratings in a photosensitive polymer using a two-beam interference method and has four diffraction gratings in the sample plane, with a same distance from the opening center and oriented four-fold symmetrically. Four first-order diffracted beams by the gratings and one non-diffracted central beam overlap and form three-dimensional interference pattern. The phase of one side beam is delayed by inserting a thin piece of microscope glass slide into the beam. By rotating the glass slide thus tuning the phase of the side beam, the five beam interference pattern changes from facecenter tetragonal symmetry into desired diamond-like lattice symmetry. The three-dimensional interference pattern is recorded in a photosensitive polymer, showing the phase tuning related changes of photonic lattice structures. Combing an amplitude mask with the phase mask by putting the amplitude mask in the central opening of the diffraction optical element mask, line defects are produced within the photonic crystal template.