Miracle-dz/UniFAR-FTUs huggingface dataset:
The Ultrastructural Basis of Transcapillary Exchanges

A brief survey is given of current views correlating the ultrastructural and permeability characteristics of capillaries. Observations based on the use of peroxidase (mol wt 40,000), as an in vivo, and colloidal lanthanum, as an in vitro, ultrastructural tracer, are presented. In capillaries with "continuous" endothelium, the endothelial intercellular junctions are thought to be permeable to the tracers, and are regarded as maculae occludentes rather than zonulae occludentes, with a gap of about 40 A in width between the maculae. Some evidence for vesicular transport is also presented. It is inferred that the cell junctions are the morphological equivalent of the small-pore system, and the vesicles the equivalent of the large-pore system. Peroxidase does not apparently cross brain capillaries: the endothelial cell junctions are regarded as zonulae occludentes, and vesicles do not appear to transport across the endothelium. This is regarded as the morphological equivalent of the blood-brain barrier for relatively large molecules. The tracers appear to permeate the fenestrae of fenestrated capillaries, and the high permeability of these capillaries to large molecules is attributed to the fenestrae. Capillaries with discontinuous endothelium readily allow passage of the tracers through the intercellular gaps. A continuous basement membrane may act as a relatively coarse filter for large molecules. In general, the morphology of capillaries correlates well with physiological observations.
Epidural Analgesia and Risk of Anastomotic Leakage

Background and Objectives Based on case reports of early anastomotic leakage in patients receiving epidural analgesia with local anesthetic and data to document a stimulatory effect of epidural block on gastrointestinal motility, it has been suggested that continuous infusion of epidural local anesthetic may lead to an increased incidence of anastomotic leakage. Therefore, we examined the association between continuous epidural local anesthetic and anastomotic leakage by reviewing the literature. Methods Review of controlled, randomized clinical trials aiming to investigate postoperative complications in which continuous postoperative epidural local anesthetic was administered in patients scheduled for colorectal surgery with an anastomosis. Data were obtained from a Medline search (1966-May 2000), previous review articles, references cited in original papers, and personal communication with investigators. Twelve trials including a total of 562 patients met the inclusion criteria. Results Sixteen of 266 patients (6.0%, 95% confidence interval [CI]: 3.5% to 9.6%) receiving postoperative epidural local anesthetic or epidural local anesthetic-opioid mixtures developed anastomotic leakage, compared with 10 of 296 patients (3.4%, 95% CI: 1.6% to 6.1%) receiving epidural or systemic opioid-based analgesia (P > .05 between groups, Fisher’s test). The risk of overlooking a significant difference (type II error) was approximately 67% (power: 33%). Studies including more than 1,037 patients in each group are needed to demonstrate an increased risk of anastomotic leakage from 3.4% to 6.0% with 80% power and 2α = 0.05. There was no significant difference (P > .05 between groups, Fisher’s test) between subgroups of study design: Epidural local anesthetic versus systemic or epidural opioid, or epidural local anesthetic-opioid mixtures versus systemic or epidural opioid. Conclusions So far, there is no statistically significant evidence from randomized trials to indicate epidural analgesia with local anesthetic to be associated with an increased risk of anastomotic breakdown. However, relatively few patients have been included in randomized trials, indicating a need for more studies to secure valid conclusions.
Active Screening in High-Risk Units Is an Effective and Cost-Avoidant Method to Reduce the Rate of Methicillin-Resistant Staphylococcus aureus Infection in the Hospital

Objective. To evaluate the impact of active screening for methicillin-resistant Staphylococcus aureus (MRSA) on MRSA infection rates and cost avoidance in units where the risk of MRSA transmission is high. Methods. During a 15-month period, all patients admitted to our adult medical and surgical intensive care units (ICUs) were screened for MRSA nasal carriage on admission and weekly thereafter. The overall rates of all MRSA infections and of nosocomial MRSA infection in the 2 adult ICUs and the general wards were compared with rates during the 15-month period prior to the start of routine screening. The percentage of patients colonized or infected with MRSA on admission and the cost avoidance of the surveillance program were also assessed. Results. The overall rate of MRSA infections for all 3 areas combined decreased from 6.1 infections per 1,000 census-days in the preintervention period to 4.1 infections per 1,000 census-days in the postintervention period (P = .01). The decrease remained statistically significant when only nosocomial MRSA infections were examined (4.5 vs 2.8 infections per 1,000 census-days; P<.01), despite a corresponding increase during the postintervention period in the percentage of patients with onset of MRSA infection in the first 72 hours after admission to the general wards (46% to 81%; P<.005). A total of 3.7% of ICU patients were colonized or infected with MRSA on admission; MRSA would not have been detected in 91% of these patients if screening had not been performed. At a cost of $3,475/month for the program, we averted a mean of 2.5 MRSA infections/month for the ICUs combined, avoiding $19,714/month in excess cost in the ICUs. Conclusions. Even in a setting of increasing community-associated MRSA, active MRSA screening as part of a multi-factorial intervention targeted to high-risk units may be an effective and cost-avoidant strategy for achieving a sustained decrease of MRSA infections throughout the hospital.
Optimal bidding strategies of GENCO under uncertain information of rivals using CVaR

Due to transmission and other constraints, competitive electricity markets are oligopoly instead of perfectly competitive. Hence, Gencos are required to bid strategically to get more profit but the rivals complete information is not available. A strategic producer is considered who trades in day-ahead electricity market with imperfect information of rivals obtained from the historical data. Using this information, an optimization framework is developed to devise optimal bids for maximum profit with minimum risk. Conditional value at risk (CVaR) is used for the risk due to uncertain information of rival's bids. The proposed method has been tested on a six generator example and optimal solution is obtained with efficient frontier between expected losses and CVaR.
Pattern Dictionary Development Based on Non-Compositional Language Model for Japanese Compound and Complex Sentences

A large-scale sentence pattern dictionary (SP-dictionary) for Japanese compound and complex sentences has been developed. The dictionary has been compiled based on the non-compositional language model. Sentences with 2 or 3 predicates are extracted from a Japanese-to-English parallel corpus of 1 million sentences, and the compositional constituents contained within them are generalized to produce a SP-dictionary containing a total of 215,000 pattern pairs. In evaluation tests, the SP-dictionary achieved a syntactic coverage of 92% and a semantic coverage of 70%.
A Compositional Approach toward Dynamic Phrasal Thesaurus

To enhance the technology for computing semantic equivalence, we introduce the notion of phrasal thesaurus which is a natural extension of conventional word-based the saurus. Among a variety of phrases that conveys the same meaning, i.e., paraphrases, we focus on syntactic variants that are compositionally explainable using a small number of atomic knowledge, and develop a system which dynamically generates such variants. This paper describes the proposed system and three sorts of knowledge developed for dynamic phrasal thesaurus in Japanese: (i) transformation pattern, (ii) generation function, and (iii) lexical function.
ReviewThe biology of incretin hormones

Gut peptides, exemplified by glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are secreted in a nutrient-dependent manner and stimulate glucose-dependent insulin secretion. Both GIP and GLP-1 also promote b cell proliferation and inhibit apoptosis, leading to expansion of b cell mass. GLP-1, but not GIP, controls glycemia via additional actions on glucose sensors, inhibition of gastric emptying, food intake and glucagon secretion. Furthermore, GLP-1, unlike GIP, potently stimulates insulin secretion and reduces blood glucose in human subjects with type 2 diabetes. This article summarizes current concepts of incretin action and highlights the potential therapeutic utility of GLP-1 receptor agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors for the treatment of type 2 diabetes.
Dynamic FAUST: Registering Human Bodies in Motion

While the ready availability of 3D scan data has influenced research throughout computer vision, less attention has focused on 4D data, that is 3D scans of moving non-rigid objects, captured over time. To be useful for vision research, such 4D scans need to be registered, or aligned, to a common topology. Consequently, extending mesh registration methods to 4D is important. Unfortunately, no ground-truth datasets are available for quantitative evaluation and comparison of 4D registration methods. To address this we create a novel dataset of high-resolution 4D scans of human subjects in motion, captured at 60 fps. We propose a new mesh registration method that uses both 3D geometry and texture information to register all scans in a sequence to a common reference topology. The approach exploits consistency in texture over both short and long time intervals and deals with temporal offsets between shape and texture capture. We show how using geometry alone results in significant errors in alignment when the motions are fast and non-rigid. We evaluate the accuracy of our registration and provide a dataset of 40,000 raw and aligned meshes. Dynamic FAUST extends the popular FAUST dataset to dynamic 4D data, and is available for research purposes at http://dfaust.is. tue.mpg. de.
Transcriptomic Analysis Shows Decreased Cortical Expression of NR4A1, NR4A2 and RXRB in Schizophrenia and Provides Evidence for Nuclear Receptor Dysregulation

Many genes are differentially expressed in the cortex of people with schizophrenia, implicating factors that control transcription more generally. Hormone nuclear receptors dimerize to coordinate context-dependent changes in gene expression. We hypothesized that members of two families of nuclear receptors (NR4As), and retinoid receptors (RARs and RXRs), are altered in the dorsal lateral prefrontal cortex (DLPFC) of people with schizophrenia. We used next generation sequencing and then qPCR analysis to test for changes in mRNA levels for transcripts encoding nuclear receptors: orphan nuclear receptors (3 in the NR4A, 3 in the RAR, 3 in the RXR families and KLF4) in total RNA extracted from the DLPFC from people with schizophrenia compared to controls (n = 74). We also correlated mRNA levels with demographic factors and with estimates of antipsychotic drug exposure (schizophrenia group only). We tested for correlations between levels of transcription factor family members and levels of genes putatively regulated by these transcription factors. We found significantly down regulated expression of NR4A1 (Nurr 77) and KLF4 mRNAs in people with schizophrenia compared to controls, by both NGS and qPCR (p = or <0.01). We also detected decreases in NR4A2 (Nurr1) and RXRB mRNAs by using qPCR in the larger cohort (p<0.05 and p<0.01, respectively). We detected decreased expression of RARG and NR4A2 mRNAs in females with schizophrenia (p<0.05). The mRNA levels of NR4A1, NR4A2 and NR4A3 were all negative correlated with lifetime estimates of antipsychotic exposure. These novel findings, which may be influenced by antipsychotic drug exposure, implicate the orphan and retinoid nuclear receptors in the cortical pathology found in schizophrenia. Genes down stream of these receptors can be dysregulated as well, but the direction of change is not immediately predictable based on the putative transcription factor changes.
Efficient bit allocation for an arbitrary set of quantizers [speech coding]

A bit allocation algorithm that is capable of efficiently allocating a given quota of bits to an arbitrary set of different quantizers is proposed. This algorithm is useful in any coding scheme which uses bit allocation or, more generally, codebook allocation. It produces an optimal or very nearly optimal allocation, while allowing the set of admissible bit allocation values to be constrained to nonnegative integers. It is particularly useful in cases where the quantizer performance versus rate is irregular and changing in time, a situation that cannot be handled by conventional allocation algorithms. >
Space Efficient Secret Sharing

This note proposes a method of space efficient secret sharing i n which k secrets are mapped into n shares (nk) of the same size. Since, n can be chosen to be equal to k, the method is space efficient. This method may be compared with conventional secret sharing schemes that divide a single secret into n shares.
Personality predicts individual responsiveness to the risks of starvation and predation

Theory suggests that individual personality is tightly linked to individual life histories and to environmental variation. The reactive–proactive axis, for example, is thought to reflect whether individuals prioritize productivity or survival, mutually exclusive options that can be caused by conflicts between foraging and anti-predation behaviour. Evidence for this trade-off hypothesis, however, is limited. Here, we tested experimentally whether exploration behaviour (EB), an assay of proactivity, could explain how great tits (Parus major) respond to changes in starvation and predation risk. Individuals were presented with two feeders, holding good or poor quality food, which interchanged between safe and dangerous positions 10 m apart, across two 24 h treatments. Starvation risk was assumed to be highest in the morning and lowest in the afternoon. The proportion of time spent feeding on good quality food (PTG) rather than poor quality food was repeatable within treatments, but individuals varied in how PTG changed with respect to predation- and starvation-risk across treatments. This individual plasticity variation in foraging behaviour was linked to EB, as predicted by the reactive–proactive axis, but only among individuals in dominant social classes. Our results support the trade-off hypothesis at the level of individuals in a wild population, and suggest that fine-scale temporal and spatial variation may play important roles in the evolution of personality.
Modeling the status, trends, and impacts of wild bee abundance in the United States

Significance In 2014, a presidential memorandum called for an assessment of the nation’s pollinators, in response to growing awareness of their economic importance and recent declines. We assess, for the first time to our knowledge, the status and trends of wild bee abundance and their potential impacts on pollination services across the United States. We develop national maps of wild bee abundance, report land-use–driven changes over time, and relate them to trends in agricultural demand for pollination. We estimate uncertainty in the findings, so future research can target the least-understood regions and topics. Our findings can also help focus conservation efforts where declines in bee abundance are most certain, especially where agricultural demand for pollination services is growing. Wild bees are highly valuable pollinators. Along with managed honey bees, they provide a critical ecosystem service by ensuring stable pollination to agriculture and wild plant communities. Increasing concern about the welfare of both wild and managed pollinators, however, has prompted recent calls for national evaluation and action. Here, for the first time to our knowledge, we assess the status and trends of wild bees and their potential impacts on pollination services across the coterminous United States. We use a spatial habitat model, national land-cover data, and carefully quantified expert knowledge to estimate wild bee abundance and associated uncertainty. Between 2008 and 2013, modeled bee abundance declined across 23% of US land area. This decline was generally associated with conversion of natural habitats to row crops. We identify 139 counties where low bee abundances correspond to large areas of pollinator-dependent crops. These areas of mismatch between supply (wild bee abundance) and demand (cultivated area) for pollination comprise 39% of the pollinator-dependent crop area in the United States. Further, we find that the crops most highly dependent on pollinators tend to experience more severe mismatches between declining supply and increasing demand. These trends, should they continue, may increase costs for US farmers and may even destabilize crop production over time. National assessments such as this can help focus both scientific and political efforts to understand and sustain wild bees. As new information becomes available, repeated assessments can update findings, revise priorities, and track progress toward sustainable management of our nation’s pollinators.
SMART on FHIR Genomics: facilitating standardized clinico-genomic apps

BACKGROUND Supporting clinical decision support for personalized medicine will require linking genome and phenome variants to a patient's electronic health record (EHR), at times on a vast scale. Clinico-genomic data standards will be needed to unify how genomic variant data are accessed from different sequencing systems. METHODS A specification for the basis of a clinic-genomic standard, building upon the current Health Level Seven International Fast Healthcare Interoperability Resources (FHIR®) standard, was developed. An FHIR application protocol interface (API) layer was attached to proprietary sequencing platforms and EHRs in order to expose gene variant data for presentation to the end-user. Three representative apps based on the SMART platform were built to test end-to-end feasibility, including integration of genomic and clinical data. RESULTS Successful design, deployment, and use of the API was demonstrated and adopted by HL7 Clinical Genomics Workgroup. Feasibility was shown through development of three apps by various types of users with background levels and locations. CONCLUSION This prototyping work suggests that an entirely data (and web) standards-based approach could prove both effective and efficient for advancing personalized medicine.
Social Work with older adults in the United States

This article examines ageing services in the United States, which are provided and financed through a mixed economy of care that includes government, the voluntary sector, and the private market. Because of substantial unmet needs, poorly coordinated systems, and social and economic disparities among older adults in the United States, social-work services have an important role to play in overcoming barriers to optimal functioning and emotional well-being in later life. Existing evidence suggests that the ability of social work to meet the needs of a growing ageing population is hampered by insufficient numbers of social workers with adequate training and competence in ageing. The article analyses and discusses recent advances in social work education in the United States designed to produce greater numbers of ageing-competent social work professionals, including initiatives in aging-related curriculum development, training, organisational development, and scholarship.
Update on Grass Phylogeny and C 4 Research Integrating Phylogeny into Studies of C 4 Variation in the Grasses

Department of Ecology and Evolution, University of Lausanne, 1015 Lausanne, Switzerland (P.-A.C., N.S., G.B.); Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland (N.S.); Department of Biology, University of Missouri, St. Louis, Missouri 63121 (E.A.K.); and Center for Tropical Forest Science, Smithsonian Tropical Research Institute, Apartado Postal 0843–03092, Panama, Republic of Panama (A.V.)
A FAST PARTICLE SWARM OPTIMIZATION

Particle swarm optimization (PSO) is a popular and robust strategy for optimization problems. One main difficulty in applying PSO to real-world applications is that PSO usually need a large number of fitness evaluations before a satisfying result can be obtained. This paper introduces a new "fast particle swarm optimization" (FPSO) that does not evaluate all new positions owning a fitness and associated reliability value of each particle of the swarm and the reliability value is only evaluated using the true fitness function if the reliability value is below a threshold. Moreover, applying random evaluation, reliability value update and self-adaptive threshold strategies to the FPSO further enhances the performance of the algorithm.
Clinical and Electrophysiological Effects of Extraocular Muscle Surgery on Patients with Infantile Nystagmus Syndrome (INS)

The purpose of this report is to summarize clinical and electrophysiological effects of extraocular muscle surgery in patients with INS. Our hypothesis is that surgery on the extraocular muscles of patients with INS changes their nystagmus resulting in improved vision and visual functions. All patients had all four virgin horizontal recti operated on, either for strabismus alone, nystagmus alone, for a head posture due to an eccentric null zone alone or for a head posture due to an eccentric null zone plus strabismus. All patients have been followed for at least 12 months. Subjective outcome measures include the pre- and post-operative binocular best optically corrected null zone acuity (NZA) in 75 patients and gaze dependent acuity (GDA) in 12 patients. Objective outcome measure included null zone width (NZW) in 75 patients. The results are summarized as follows: NZA increased. 1 LogMar or greater in 75% with those patients ≤8 years significantly better. Subjective GDA and NZW measured from eye movement recordings showed persistent, significant increases. This report adds to the evidence that surgery on the extraocular muscles in patients with INS has independent neurological and visual results, from simply reposition the head, eye(s) or visual axis.
On the geographic patterns of a large-scale mobile video-on-demand system

The widespread availability of smart mobile terminals along with the ever increasing bandwidth capabilities has promoted the popularity of mobile Internet video systems. Understanding the geographic features of mobile content consumption is of an extreme importance for the design and the performance optimization of a mobile video delivery system. This paper is a first step towards characterization of the geographic patterns of a large-scale commercial mobile video-on-demand (VoD) system, by measuring both uniformity and intensity of geographic interests on videos. In particular, we identify a geographical concentration effect of views for individual videos, which is however dependent on video popularity. We also analyze the temporal evolution trends of the geographic popularity which reveal distinct behavior of popular and non-popular videos. While the set of locations that contribute to most of the views of non-popular videos largely varies, the daily geographic popularity distribution of popular videos closely follows the distribution of global traffic and remains stable. We also examine the impact of content type and viewing sources on the geographic features of mobile videos consumption, and the correlation between content similarity and geographic locality. Finally, we provide insights into the implications of our findings.