Miracle-dz/UniFAR-FTUs huggingface dataset:
FUNCTIONAL MODIFICATION OF DENDRITIC CELLS WITH RECOMBINANT ADENOVIRUS ENCODING INTERLEUKIN 10 FOR THE TREATMENT OF SEPSIS

Control of dendritic cell (DC) function is critical for strategies to modulate innate and acquired immune responses. We examined whether transduction of murine DCs with adenoviral vectors (Adv) expressing interleukin (IL)-10 could alter their phenotype and T cell stimulatory function. Murine bone marrow-derived DCs were transduced with AdV encoding human IL-10 or green fluorescent protein (GFP). Whereas transduction of immature DCs with AdV/GFP resulted in dose-dependent maturation, DCs transduced with Adv/IL-10 maintained an immature state with low major histocompatibility complex (MHC) class II, CD86, and IL-12 expression. The Adv/IL-10 transduced DCs were phenotypically unique, characterized by suppression of IL-12 expression, failure to stimulate Th1 or Th2 cytokine responses, and retained capacity to endocytose antigen. Importantly, Adv/IL-10-transduced DCs were biologically active in vivo, in that administration of these DCs into mice before a generalized peritonitis significantly improved survival. We conclude that Adv/IL-10 transduction of DCs provides an efficient means to modulate DC function. The capacity to modify DCs by adenoviral expression of IL-10 may provide a novel ex vivo or in vivo approach to mitigate acute and chronic inflammatory diseases like sepsis.
Design of interior PM machines for field-weakening applications

There has been considerable recent interest in the use of interior PM machines for field-weakening applications such as traction which require a wide constant power speed range. This paper discusses the requirements of example constant power applications; explains how equivalent circuit analysis can provide useful insights into the machine parameter selection; demonstrates the importance of the choice of the rotor barrier locations and number of stator slots on the iron loss; and summarizes other machine design aspects such as modeling, calculation of losses and optimization.
Depression at antiretroviral therapy initiation and clinical outcomes among a cohort of Tanzanian women living with HIV

Objective: The objective of the study was to assess the relationship of depression at antiretroviral therapy (ART) initiation with mortality and clinical outcomes among Tanzanian women living with HIV. Design: We conducted a prospective cohort study of 1487 women who initiated ART in Dar es Salaam, Tanzania. Methods: Symptoms of depression and anxiety were assessed using a Tanzanian-adapted and validated version of the Hopkins Symptom Checklist. Participants attended monthly clinic visits during the first 2 years of ART and CD4+ T-cell counts were assessed every 4 months. Proportional hazard models were used to assess the relationship of depression with mortality and clinical outcomes. Results: Symptoms consistent with depression were prevalent among 57.8% of women at ART initiation. After multivariate adjustment, including social support and stigma, depression at ART initiation was associated with increased risk of mortality [hazard ratio (HR): 1.92; 95% confidence interval (CI): 1.15–3.20; P = 0.01] and incidence of severe anemia (hemoglobin <8.5 g/dl; HR: 1.59; 95% CI: 1.07–2.37; P = 0.02). Under the assumption of causality, we estimate 36.1% (95% CI: 13.6–55.1%) of deaths among the study cohort were attributable to depression and its consequences. Depression was not significantly associated with trajectory of CD4+ T-cell reconstitution or the risk of immunologic failure (P values >0.05). Conclusion: Elimination of depression may reduce mortality during the first 2 years of ART by one-third in our study cohort. Randomized trials and rigorous implementation studies are needed to evaluate the individual and population-level effects of integrated mental health interventions and HIV treatment approaches in resource-limited settings.
From Raw Corpus to Word Lattices: Robust Pre-parsing Processing with SxPipe

We present a robust full-featured architecture to preprocess text before parsing. This architecture, called SxPipe, converts raw noisy corpora into word lattices, one by sentence, that can be used as input by a parser. It includes sequentially named-entity recognition, tokenization and sentence boundaries detection, lexicon-aware named-entity recognition, spelling correction, and non-deterministic multi-words processing, re-accentuation and un-/re-capitalization. Though our system currently deals with the French language, almost all components are in fact language-independent, and the others can be straightforwardly adapted to virtually any inﬂectional language. The output is a sequence of word lattices, all words being present in the lexicon. It has been applied on a large scale during a French parsing evaluation campaign and during experiments of large corpora parsing, showing both good efﬁciency and very satisfying precision and recall.
Teaching like an artist: the pedagogic identities and practices of artists in schools

This article reports findings from an ethnographic study of the arts curriculum and pedagogy in a British primary school. The policy context for the study is the school's involvement in promoting creative partnerships between teachers and artists. The pedagogies of three different artist‐led projects are analysed, using a Bernsteinian framework, and are characterised in relation to notions of ‘competence’ and ‘performance’ pedagogies. These characterisations are then used to consider the impact of the artists' pedagogies on teachers in the school, and the extent to which the different pedagogies promote inclusion. Broad conclusions are drawn about the relative difficulty of adopting competence pedagogies in the current educational culture of British schools; more specific conclusions are drawn about the importance of time, text, discourse and interpretation in arts pedagogies.
Social documentary and personal investigations in contemporary South African photography: Tracey Derrick’s “One in Nine” series

A shell of white gauze floats against a split background in Tracey Derrick’s 2009 photograph, Inhabit – Habergeon – middle English, piece of armour to protect the neck and chest (Inhabit), both autonomous and materially frail. The shadowed wall lifts the calcified gauze towards the viewer, as its lithe body hovers above the vertical divide that separates light from dark. This position apart from the edge may be read as a passage missed or overcome. A year of invasive treatment following her diagnosis of stage two breast cancer in March of 2008 led South African documentary photographer Tracey Derrick to create a photographic series that combines her humanist sensibility with personal reflections on illness. Derrick represents meditations on her trajectory through illness in “One in Nine: My Year as a Statistic,” a collection of reposeful digital colour photographs – including Inhabit – that features the cast Derrick made to obtain accurate measurements for her prosthesis. This body of work complicates a widely held assumption that post-apartheid photography in South Africa focuses more on the individual than collective societal issues. Derrick’s unusual series warrants methodological treatment that attends to the complex ways in which the visual vocabulary and concerns of apartheid-era documentary photography overlap with the personal explorations associated with post-1994 photographic production. In this paper, I utilise socio-historical, psychoanalytic and phenomenological readings of Tracey Derrick’s photograph and “One in Nine” series to elicit an interpretation of the image and series as statement of agency within a metaphorical battle against an invisible, yet pervasive disease. By reading Derrick’s photograph through these theoretical lenses, I reveal her image to be a metaphoric assertion of tenacity and Derrick’s agency, and highlight the areas of overlap between Derrick’s documentary practice and her more personal “One in Nine” project.
Prophenoloxidase Activation Is Required for Survival to Microbial Infections in Drosophila

The melanization reaction is a major immune response in Arthropods and involves the rapid synthesis of melanin at the site of infection and injury. A key enzyme in the melanization process is phenoloxidase (PO), which catalyzes the oxidation of phenols to quinones, which subsequently polymerize into melanin. The Drosophila genome encodes three POs, which are primarily produced as zymogens or prophenoloxidases (PPO). Two of them, PPO1 and PPO2, are produced by crystal cells. Here we have generated flies carrying deletions in PPO1 and PPO2. By analyzing these mutations alone and in combination, we clarify the functions of both PPOs in humoral melanization. Our study shows that PPO1 and PPO2 are responsible for all the PO activity in the hemolymph. While PPO1 is involved in the rapid early delivery of PO activity, PPO2 is accumulated in the crystals of crystal cells and provides a storage form that can be deployed in a later phase. Our study also reveals an important role for PPO1 and PPO2 in the survival to infection with Gram-positive bacteria and fungi, underlining the importance of melanization in insect host defense.
L U C a S S E Q U E N C E S and F U N C T I O N S O F a 3-by-3 M a T R I X

where he took trace(X) = p and det(X) = q. In so doing, he established various infinite sums involving terms from {U„} and {F„}. Following Barakat, Walton [13] evaluated the series for the sine and cosine functions at the matrix X and obtained further infinite sums involving terms from {Un} and {Vn}. Extensions of these ideas to higher-order recurrences have been given by Shannon and Horadam [12] and Pethe [11]. Recently, many papers have appeared which have followed the theme of these writers. See, for example, Brugia and Filipponi [5], Filipponi and Horadam [6], Horadam and Filipponi [8], and Melham and Shannon [10]. In this paper we apply the techniques of the above writers to a 3-by-3 matrix to obtain new infinite sums involving squares of terms from the sequences {[/„} and {Vn}.
On Maximizing the Within-Cluster Homogeneity of Speaker Voice Characteristics For Speech Utterance Clustering

This paper investigates the problem of how to partition unknown speech utterances into clusters, such that the overall within-cluster homogeneity of speakers' voice characteristics can be maximized. The within-cluster homogeneity is characterized by the likelihood probability that a cluster model, trained using all the utterances within a cluster, matches each of the within-cluster utterances. Such probability is then maximized by using a genetic algorithm, which determines the best cluster where each utterance should be located. For greater computational efficiency, also proposed is an alternative solution that approximates the likelihood probability with a divergence-based model similarity. The method is further designed to estimate the optimal number of clusters automatically
Connectivity of Large Scale Networks: Distribution of Isolated Nodes

Connectivity is one of the most fundamental properties of wireless multi-hop networks. A network is said to be connected if there is a path between any pair of nodes. A convenient way to study the connectivity of a random network is by investigating the condition under which the network has no isolated node. The condition under which the network has no isolated node provides a necessary condition for a connected network. Further the condition for a network to have no isolated node and the condition for the network to be connected can often be shown to asymptotically converge to be the same as the number of nodes approaches infinity, given a suitably defined random network and connection model. Currently analytical results on the distribution of the number of isolated nodes only exist for the unit disk model. This study advances research in the area by providing the asymptotic distribution of the number of isolated nodes in random networks with nodes Poissonly distributed on a unit square under a generic random connection model. On that basis we derive a necessary condition for the above network to be asymptotically almost surely connected. These results, together with results in a companion paper on the sufficient condition for a network to be connected, expand recent results obtained for connectivity of random geometric graphs assuming a unit disk model to results assuming a more generic and more practical random connection model.
Challenging labor and work to survive well

economic problems that are the legacy of successive waves of industrial decline—for example, establishing a Centre for Social Justice andCommunity Action, and promoting staff as well as student volunteering and partnership relationships between the University and a range of voluntary and community organisations. Reflecting on the last 40 years or so, I am struck by the difficulty of sustaining and generalising particular strategies that are ‘militant’ in Raymond Williams’ sense. It is difficult to avoid the conclusion that a variety of projects that in oneway or another sought to challenge the hegemony of capitalist imperatives, at the end of the day—to borrow Nancy Fraser’s terminology—turned out to be accommodative rather than transformative. Just as the anti-closure campaigns of the 1970s and 1980s failed effectively to contest the dominant political-economic imperatives of a capitalist economy and a state strategy committed to privatisation, markets’ deregulation and a particular conception of enterprise, so too did the ‘bottom up’ attempts to create sustainable spaces for alternative political-economic rationales. That is not, however, to suggest that exploring those options and keeping those spaces open is a pointless activity; quite the contrary. It is precisely by developing such alternative projects and exploring conceptions of what a more morally defensible and socially just economy could be that that political space of possibilities and hope is kept open and reproduced, hopefully in an expanded fashion.
Separations, Reconciliations, and Living Apart in Cohabiting and Marital Unions.

Using data from a panel study of White young adults containing complete marital and cohabiting union histories from age 15 through 31, our goal is to track and compare the paths along which young adults arrange and time the entries and exits from marital and cohabiting unions. We focus on the incidence, duration, and outcomes of 2 dimensions that embrace residential separation: (a) separations that relate to discord in the relationship and (b) living apart from the partner or spouse for reasons other than discord. Our results show that union trajectories are dynamic and involve a heterogeneous and multidirectional array of transitions. We also find consistent differences supporting the idea that marital unions are more stable and durable than cohabiting unions.
A Deeper Justice: Economic and Social Justice as Transitional Justice in Nepal

Nepal's April 2008 election was a climactic end to a 12-year conflict. As the country transitions to peace, efforts are underway to ensure that perpetrators of killings, abductions and torture are held accountable. As valid as this goal might be, transitional justice mechanisms should not continue to neglect economic and social justice issues. This article begins by explaining economic and social injustice as both a root and a product of Nepal's conflict, and demonstrates the deep commitment reflected in Nepal's peace agreement to addressing this injustice. This is juxtaposed with international and local transitional justice efforts that concentrate overwhelmingly on civil and political rights. After addressing the possibility of relegating economic and social justice to the development and postconflict reconstruction fields, the article suggests ways in which Nepal's transitional justice efforts might pursue such justice.
Methylseleninic Acid Enhances Paclitaxel Efficacy for the Treatment of Triple-Negative Breast Cancer

A major challenge in breast cancer therapy is the lack of an effective therapeutic option for a particularly aggressive subtype of breast cancer, triple-negative breast cancer. Here we provide the first preclinical evidence that a second-generation selenium compound, methylseleninic acid, significantly enhances the anticancer efficacy of paclitaxel in triple-negative breast cancer. Through combination-index value calculation, we demonstrated that methylseleninic acid synergistically enhanced the growth inhibitory effect of paclitaxel in triple-negative breast cancer cells. The synergism was attributable to more pronounced induction of caspase-mediated apoptosis, arrest of cell cycle progression at the G2/M checkpoint, and inhibition of cell proliferation. Treatment of SCID mice bearing MDA-MB-231 triple-negative breast cancer xenografts for four weeks with methylseleninic acid (4.5 mg/kg/day, orally) and paclitaxel (10 mg/kg/week, through intraperitoneal injection) resulted in a more pronounced inhibition of tumor growth compared with either agent alone. The attenuated tumor growth correlated with a decrease in tumor cell proliferation and an induction of apoptosis. The in vivo study also indicated the safety of using methylseleninic acid in the combination regime. Our findings thus provide strong justification for the further development of methylseleninic acid and paclitaxel combination therapy for the treatment of triple-negative breast cancer.
Market Survey Research: A model for ethnobotanical education

Ethnobiological imperatives in education and NSF initiatives for improving excellence in science, technology, engineering and mathematics (STEM) education for all students were addressed by the development of a research oriented, market survey ethnobotanical project developed with the involvement of undergraduate students. This market survey project presents a model for Ethnobiological and STEM education that is adaptable to educational institutions and communities world-wide. Collaboration among users of the model and synthesis of results would provide an international look at the biocomplexity of markets systems. Students gained experience in scientific research, including: observation and forming hypothesis, collection and analysis of data, and dissemination of results. Students practiced ethnobotanical research skills, including: developing and applying an informed consent statement, producing herbarium vouchers, interacting with cultural representatives. Survey materials and hypotheses were modified during the research period to maximize our efforts. Students co-authored with instructor two publications resulting from the research involvement. The instructor gained experience by involving students in research and application of the instructor’s research to an undergraduate ethnobotanical project. Challenges are discussed, as well as recommendations synthesized from these experiences and from reviews of other student-research studies.
Thermoelectric properties of doped CoSb/sub 3/ prepared by vacuum induction melting

Skutterudite CoSb3 doped with nickel was prepared by the vacuum induction melting in an encapsulated quartz ampoule, and its doping effects on the thermoelectric properties were investigated. Single phase δ-CoSb3 was successfully obtained by vacuum induction melting and subsequent annealing. Nickel atoms acted as donors by substituting cobalt atoms. Thermoelectric properties were improved by the appropriate annealing and doping, and they were closely related to phase transitions and dopant activation.
Impact of Patient–Prosthesis Mismatch Following Aortic Valve Replacement on Short-Term Survival: A Retrospective Single Center Analysis of 632 Consecutive Patients with Isolated Stented Biological Aortic Valve Replacement

Abstract Objectives The impact of patient–prosthesis mismatch (PPM) after aortic valve replacement (AVR) on short-term and long-term mortality remains controversial. The objective of this study was to evaluate the incidence and severity of PPM and its impact on short-term survival in a large cohort of patients treated with isolated stented biological AVR in a single institution. Methods We analyzed retrospectively data of 632 consecutive patients with aortic stenosis undergoing isolated stented biological AVR between January 2007 and February 2012 at our institution. PPM was defined as an indexed effective orifice area ≤ 0.85 cm2/m2. Statistical analyses were performed to identify influencing variables on valve size implanted. Results Of the 632 patients investigated, 46% were females and mean age was 71.9 ± 10.4 years. PPM was observed in 93.8% (593 of 632 patients). In 71% of the patients, moderate (0.65–0.85 cm2/m2) PPM was present and in 22.8% severe (< 0.65 cm2/m2) PPM was present. The 30-day mortality was 1.4% (9 of 632 patients) with all being females. PPM was not associated with increased 30-day mortality. Multiple regression analyses demonstrated the usefulness of sex, height, body mass index, and body surface area as simultaneous predictors of the valve size implanted (R 2 = 0.39). Conclusion PPM had no discernable impact on short-term survival, although it was present in 93.8% of our patients following isolated stented biological AVR.
Sequential performance on the California verbal learning test following traumatic brain injury

Abstract The performance of 35 individuals with severe traumatic brain injury (TBI) on the California Verbal Learning Test (CVLT) was examined on two occasions averaging 2 and 5 months postonset. Severe deficits in learning across trials, delayed recall, cued recall, and recognition were noted initially, with improvement evident at the second evaluation. Subjects with TBI did not reach normal levels of performance, however, based on comparisons with a control sample. Intrusion of inappropriate information during recall was more common among TBI subjects, and use of memory strategies was less than anticipated.
Replication of reticuloendotheliosis viruses in cell culture: chronic infection.

After an initial acute infection with cell killing, chicken or duck embryo fibroblasts infected in culture with reticuloendotheliosis viruses set up a chronic infection with no cell killing or morphological transformation. Essentially all of the chronically infected cells produced virus. The virus production was not sensitive to cytosine arabinoside or mitomycin C as was virus production in an acute infection. The chronically infected cells had a strong group-specific resistancto the c.p.e. of superinfecting reticuloendotheliosis viruses. However, they were sensitive to vesicular stomatitis virus and avian leukosis-sarcoma viruses. After double infection, single cells produced reticuloendotheliosis virus and avian leukosis-sarcoma virus.
Dyadic Trauma in Infancy and Early Childhood: Review of the Literature

The clinical and empirical literature on trauma and loss in infancy and early childhood largely focuses on children's exposure to traumatic events, direct “event trauma. ” This article seeks to expand the definition of trauma in infancy to include “indirect trauma,” implicit emotional and relational events, such as infant exposure to traumatized parents, which occurred in the Project for Mothers, Infants, and Young Children of September 11, 2001, described in this issue. Four empirical literatures are reviewed to develop an understanding of the cognitive, behavioral, and social sequelae of early trauma and parental loss: (1) research on childhood trauma symptoms in the verbal period; (2) research on child and parent attachment security and the parent-child relationship; (3) research on the preverbal period of infant development, specifically addressing nonverbal parent-child communication patterns; and (4) research on the impact of maternal trauma prenatally, on the infant's capacity to remember and represent trauma occurring preverbally, and on the effect of early trauma on neurological development. The article argues that trauma and treatment in infancy and early childhood should be construed as dyadic, occurring between parent and child.