Miracle-dz/UniFAR-FTUs huggingface dataset:
OFDM-Subcarrier Index Selection for Enhancing Security and Reliability of 5G URLLC Services

An efficient physical layer security technique, referred to as OFDM with subcarrier index selection (OFDM-SIS), is proposed for safeguarding the transmission of OFDM-based waveforms against eavesdropping in 5G and beyond wireless networks. This is achieved by developing a joint optimal subcarrier index selection (SIS) and adaptive interleaving (AI) design, which enables providing two levels (sources) of security in time division duplexing (TDD) mode: one is generated by the optimal selection of the subcarrier indices that can maximize the signal-to-noise ratio at only the legitimate receiver, while the other is produced by the AI performed based on the legitimate user’s channel that is different from that of the eavesdropper. The proposed scheme not only provides a remarkable secrecy gap, but also enhances the reliability performance of the legitimate user compared with the standard OFDM scheme. Particularly, a gain of 5–10 dB is observed at a bit error rate value of 10−3 compared with standard OFDM as a result of using the adaptive channel-based subcarrier selection mechanism. Moreover, the proposed technique saves power, considers no knowledge of the eavesdropper’s channel, and provides secrecy even in the worst security scenario, where the eavesdropper can know the channel of the legitimate link when an explicit channel feedback is used as is the case in frequency division duplexing systems. This is achieved while maintaining low complexity and high reliability at the legitimate user, making the proposed scheme a harmonious candidate technique for secure 5G ultra reliable and low latency communications (URLLC) services.
HIGHER-ORDER OR CRITICAL THINKING SKILLS: DOES ACCOUNTING EDUCATION NEED REFORMS?

Var ious authors point out the repeated calls by stakeholders in the accounting profession for the development of enhanced critical skills in accounting graduates to ensure the long-term development of the profession. This paper discusses the importance of developing higher-order or critical thinking skills among accounting graduates prior to entering the job market. It identifies the two steps needed to improve accounting education, namely to recognise the need for change and to identify the specific changes needed. Critical thinking skills are needed to enable accounting graduates to cope not only with advancements in Information Technology, but also a competitive business environment in a globalised world economy.
Population-based screening for breast and ovarian cancer risk due to BRCA1 and BRCA2

Significance Inherited mutations in the tumor suppressor genes BRCA1 and BRCA2 predispose to very high risks of breast and ovarian cancer. For carriers of these mutations, risk-reducing surgery significantly reduces morbidity and mortality. General population screening for BRCA1 and BRCA2 mutations in young adult women could be feasible if accurate estimates of cancer risk for mutation carriers could be obtained. We determined that risks of breast and ovarian cancer for BRCA1 and BRCA2 mutation carriers ascertained from the general population are as high as for mutation carriers ascertained through personal or family history of cancer. General screening of BRCA1 and BRCA2 would identify many carriers who are currently not evaluated and could serve as a model for population screening for genetic predisposition to cancer. In the Ashkenazi Jewish (AJ) population of Israel, 11% of breast cancer and 40% of ovarian cancer are due to three inherited founder mutations in the cancer predisposition genes BRCA1 and BRCA2. For carriers of these mutations, risk-reducing salpingo-oophorectomy significantly reduces morbidity and mortality. Population screening for these mutations among AJ women may be justifiable if accurate estimates of cancer risk for mutation carriers can be obtained. We therefore undertook to determine risks of breast and ovarian cancer for BRCA1 and BRCA2 mutation carriers ascertained irrespective of personal or family history of cancer. Families harboring mutations in BRCA1 or BRCA2 were ascertained by identifying mutation carriers among healthy AJ males recruited from health screening centers and outpatient clinics. Female relatives of the carriers were then enrolled and genotyped. Among the female relatives with BRCA1 or BRCA2 mutations, cumulative risk of developing either breast or ovarian cancer by age 60 and 80, respectively, were 0.60 (± 0.07) and 0.83 (± 0.07) for BRCA1 carriers and 0.33 (± 0.09) and 0.76 (± 0.13) for BRCA2 carriers. Risks were higher in recent vs. earlier birth cohorts (P = 0.006). High cancer risks in BRCA1 or BRCA2 mutation carriers identified through healthy males provide an evidence base for initiating a general screening program in the AJ population. General screening would identify many carriers who are not evaluated by genetic testing based on family history criteria. Such a program could serve as a model to investigate implementation and outcomes of population screening for genetic predisposition to cancer in other populations.
TP53 mutations in familial breast cancer: Functional aspects

Mutation in p53 (TP53) remains one of the most commonly described genetic events in human neoplasia. The occurrence of mutations is somewhat less common in sporadic breast carcinomas than in other cancers, with an overall frequency of about 20%. There is, however, evidence that p53 is mutated at a significantly higher frequency in breast carcinomas arising in carriers of germ‐line BRCA1 and BRCA2 mutations. Some of the p53 mutants identified in BRCA1 and BRCA2 mutation carriers are either previously undescribed or infrequently reported in sporadic human cancers. Functional characterization of such mutants in various systems has revealed that they frequently possess properties not commonly associated with those occurring in sporadic cases: they retain apoptosis‐inducing, transactivating, and growth‐inhibitory activities similar to the wild‐type protein, yet are compromised for transformation suppression and also possess an independent transforming phenotype. The occurrence of such mutants in familial breast cancer implies the operation of distinct selective pressures during tumorigenesis in BRCA‐associated breast cancers. Hum Mutat 21:301–306, 2003. © 2003 Wiley‐Liss, Inc.
Psychological Factors and Reticuloendothelial Disease: IV. Observations on a Group of Children and Adolescents with Leukemia: An Interpretation of Disease Development in Terms of the Mother Child Unit

Summary Observations are reported on 33 children and adolescents below age 20 with leukemia. The usual diagnostic categories, symptoms, and age and sex distribution occurred in this group. The frequency of various types of loss, separation, or threats of separation for the individual child is described. These losses included advent of a sibling rival, change of home, change of school, and loss or threat of loss of a significant person such as the father or maternal grandparents through death or illness. One or more of these kinds of losses occurred for 31 of the 33 patients. Half of such separations or losses during the 2‐year prodromal period occurred during 6 months prior to the apparent onset of the disease. In addition, 27 of the 33 mothers were depressed and/or anxious for weeks or months before evident symptoms developed in the child. From the data observed in these patients, we consider that separation from a significant object with ensuing depression may be one of the conditions determining manifest development of leukemia in children as our previous studies suggested in adults. The findings in the individual patient and his or her mother are discussed in the perspective of the mother‐child unit, meaning a mutual psychophysiologic unit in prenatal as well as postnatal development of the child with the mother. From these considerations, formulations are proposed for comprehending some of the multiple conditions determining the occurrence of leukemia in an individual child.
Distinct Roles for CCR4 and CXCR3 in the Recruitment and Positioning of Regulatory T Cells in the Inflamed Human Liver

Regulatory T cells (Tregs) are found at sites of chronic inflammation where they mediate bystander and Ag-specific suppression of local immune responses. However, little is known about the molecular control of Treg recruitment into inflamed human tissues. We report that up to 18% of T cells in areas of inflammation in human liver disease are forkhead family transcriptional regulator box P3 (FoxP3)+ Tregs. We isolated CD4+CD25+CD127lowFoxP3+ Tregs from chronically inflamed human liver removed at transplantation; compared with blood-derived Tregs, liver-derived Tregs express high levels of the chemokine receptors CXCR3 and CCR4. In flow-based adhesion assays using human hepatic sinusoidal endothelium, Tregs used CXCR3 and α4β1 to bind and transmigrate, whereas CCR4 played no role. The CCR4 ligands CCL17 and CCL22 were absent from healthy liver, but they were detected in chronically inflamed liver where their expression was restricted to dendritic cells (DCs) within inflammatory infiltrates. These DCs were closely associated with CD8 T cells and CCR4+ Tregs in the parenchyma and septal areas. Ex vivo, liver-derived Tregs migrated to CCR4 ligands secreted by intrahepatic DCs. We propose that CXCR3 mediates the recruitment of Tregs via hepatic sinusoidal endothelium and that CCR4 ligands secreted by DCs recruit Tregs to sites of inflammation in patients with chronic hepatitis. Thus, different chemokine receptors play distinct roles in the recruitment and positioning of Tregs at sites of hepatitis in chronic liver disease.
Promoter analysis of RPE65, the gene encoding a 61-kDa retinal pigment epithelium-specific protein.

PURPOSE To identify the functional promoter region and cis-acting elements that regulate the expression of RPE65, the retinal pigment epithelium (RPE)-specific gene responsible for certain forms of autosomal recessive childhood-onset severe retinal dystrophy. METHODS A human genomic DNA clone containing the 5'-flanking region of RPE65 was isolated and, 4.0 kb proximal to the transcription start site, was sequenced and analyzed for the presence of transcription factor-binding sites. Promoter activity was assayed by transient transfection of luciferase reporter constructs containing nested deletions of the upstream sequence in the human RPE cell lines ARPE19 and D407, as well as in the SK-Mel-28 and HeLa cell lines. Specific DNA protein-binding sites present in the 340 bp upstream of the transcription start site were identified by DNase I footprint analysis. RESULTS Sequence analysis places the polymorphic marker, D1S2803, within the RPE65 upstream region and identifies a number of sequences homologous to the gene encoding the cellular retinaldehyde-binding protein. Functional analysis indicates that basal promoter activity is conferred by the sequence from -83 to +39 and is approximately equivalent in all cell lines tested, with no other control elements detected in 3.6 kb of the upstream sequence. At least eight protected regions are identified in DNase I footprint assays, including sequences corresponding to the predicted TATA box, AP-4, and nuclear factor-1 DNA protein-binding sites. CONCLUSIONS These findings localize the basal promoter activity of RPE65, identify potential cis-acting elements that act as positive regulators of gene expression, and suggest that additional regulatory elements are likely to be involved in restricting gene expression to the retinal pigment epithelium. Identification of promoter elements and genetic markers in the upstream sequence will enable the screening of patients with retinal degeneration for possible mutations that affect RPE65 expression.
Understanding Ad Blockers

This project aims to provide useful information for users and researchers who would like to learn more about ad blocking. Three main research areas are explored in this project. The first research area provides general information about ad blocking tools and aims to explore ad blockers from a user’s perspective. The second research area provides analyses regarding third­party sites that appear on popular first­party sites in order to explore the behavior of third­parties. Finally, the third research area provides analyses regarding filter lists, which are sets of ad filtering rules used by ad blocking tools. The third research area aims to convey the differences and similarities between individual filter lists as well as sets of filter lists that form the defaults of ad blocking tools.
Analyzing multiple endpoints in a confirmatory randomized clinical trial—an approach that addresses stratification, missing values, baseline imbalance and multiplicity for strictly ordinal outcomes

Confirmatory randomized clinical trials with a stratified design may have ordinal response outcomes, ie, either ordered categories or continuous determinations that are not compatible with an interval scale. Also, multiple endpoints are often collected when 1 single endpoint does not represent the overall efficacy of the treatment. In addition, random baseline imbalances and missing values can add another layer of difficulty in the analysis plan. Therefore, the development of an approach that provides a consolidated strategy to all issues collectively is essential. For a real case example that is from a clinical trial comparing a test treatment and a control for the pain management for patients with osteoarthritis, which has all aforementioned issues, multivariate Mann‐Whitney estimators with stratification adjustment are applicable to the strictly ordinal responses with stratified design. Randomization based nonparametric analysis of covariance is applied to account for the possible baseline imbalances. Several approaches that handle missing values are provided. A global test followed by a closed testing procedure controls the family wise error rate in the strong sense for the analysis of multiple endpoints. Four outcomes indicating joint pain, stiffness, and functional status were analyzed collectively and also individually through the procedures. Treatment efficacy was observed in the combined endpoint as well as in the individual endpoints. The proposed approach is effective in addressing the aforementioned problems simultaneously and straightforward to implement.
Serum microRNA‐122 levels in different groups of patients with chronic hepatitis B virus infection

Summary. miR‐122 is a liver‐specific microRNA, which also circulates in the blood. The levels of miR‐122 in serum and plasma correlate with hepatic necroinflammation in patients with hepatitis B virus (HBV) infection. Here, we investigated whether miR‐122 levels correlate with surrogate markers for viral replication and translation. Furthermore, we examined whether miR‐122 levels differ in the different groups of HBV‐infected patients and whether miR‐122 levels may be useful to identify patients with higher or lower risk for liver disease progression. Therefore, RNA was extracted from sera of therapy‐naïve patients with HBV infection (n = 89) and from healthy volunteers (n = 19). The concentration of miR‐122 was assessed by quantitative real‐time reverse‐transcription PCR. HBs antigen and HBV DNA levels were quantified as surrogate parameters for HBV replication and translation. Liver biopsies were examined according to the histological activity index and the degree of fibrosis was assessed. We found that the miR‐122 serum concentration correlated with the level of ALT, HBV DNA and HBs antigen (r = 0.259, P < 0.05; r = 0.225, P < 0.05; r = 0.508, P < 0.001, respectively). The miR‐122 serum levels discriminated the different patient groups infected with HBV from healthy subjects (P < 0.001), and inactive carrier patients with high (>3500 IU/mL) or low (<3500 IU/mL) levels of HBs antigen could be differentiated by the miR‐122 serum concentration (P < 0.05). As serum miR‐122 levels strongly correlated with HBs antigen, it might be an indicator for viral translation. Furthermore, serum miR‐122 levels discriminated HBV carrier patients with high or low risk for disease progression and may, thus, be an additional marker for risk stratification.
Phenylhydrazine as a partial model for β‐thalassaemia red blood cell hemodynamic properties

β‐Thalassaemia is a congenital haemoglobinopathy, associated with red blood cells (RBC) anomalies, leading to impairment of their flow‐affecting properties, namely, RBC deformability, self‐aggregability, and adherence to endothelial cells (EC). Treatment of normal RBC with phenylhydrazine (PHZ) causes selective association of oxidized α‐globin chains with the membrane skeleton, leading to reduced RBC deformability, characteristic of β‐thalassaemia. PHZ has thus been used to mimic phenotypes of β‐thalassaemia RBC. The present study was undertaken to further elucidate the suitability of PHZ‐treated RBC as a model for β‐thalassemic RBC, by comparing the aggregability and adhesiveness of PHZ‐treated RBC to those of RBC from thalassaemia intermedia (TI) patients, using image analysis of RBC under flow. In addition, the externalization of phosphatidylserine (PS), a mediator of RBC/EC interaction, was determined. It was found that PHZ caused enhanced RBC adhesiveness to extracellular matrix, similar to TI‐RBC. Furthermore, in both conditions, the enhanced adhesiveness was mediated by PS translocated to the RBC surface. In contrast, PHZ treatment completely abolished RBC aggregability, while TI‐RBC aggregability was slightly elevated. It is proposed that PHZ‐treated RBC resemble β‐thalassaemia RBC in their deformability and adhesiveness, but not in their aggregability, and thus can be used as a limited model for β‐thalassaemia RBC phenotypes.
Experimental design for estimating parameters of rate‐limited mass transfer: Analysis of stream tracer studies

Tracer experiments are valuable tools for analyzing the transport characteristics of streams and their interactions with shallow groundwater. The focus of this work is the design of tracer studies in high‐gradient stream systems subject to advection, dispersion, groundwater inflow, and exchange between the active channel and zones in surface or subsurface water where flow is stagnant or slow moving. We present a methodology for (1) evaluating and comparing alternative stream tracer experiment designs and (2) identifying those combinations of stream transport properties that pose limitations to parameter estimation and therefore a challenge to tracer test design. The methodology uses the concept of global parameter uncertainty analysis, which couples solute transport simulation with parameter uncertainty analysis in a Monte Carlo framework. Two general conclusions resulted from this work. First, the solute injection and sampling strategy has an important effect on the reliability of transport parameter estimates. We found that constant injection with sampling through concentration rise, plateau, and fall provided considerably more reliable parameter estimates than a pulse injection across the spectrum of transport scenarios likely encountered in high‐gradient streams. Second, for a given tracer test design, the uncertainties in mass transfer and storage‐zone parameter estimates are strongly dependent on the experimental Damkohler number, DaI, which is a dimensionless combination of the rates of exchange between the stream and storage zones, the stream‐water velocity, and the stream reach length of the experiment. Parameter uncertainties are lowest at DaI values on the order of 1.0. When DaI values are much less than 1.0 (owing to high velocity, long exchange timescale, and/or short reach length), parameter uncertainties are high because only a small amount of tracer interacts with storage zones in the reach. For the opposite conditions (DaI ≫ 1.0), solute exchange rates are fast relative to stream‐water velocity and all solute is exchanged with the storage zone over the experimental reach. As DaI increases, tracer dispersion caused by hyporheic exchange eventually reaches an equilibrium condition and storage‐zone exchange parameters become essentially nonidentifiable.
A brain‐potential study of preparation for and execution of a task‐switch with stimuli that afford only the relevant task

Behavioural and neurophysiological studies of task‐switching have tended to employ ‘bivalent’ stimuli (which afford responses in two tasks). Using brain potential recordings, we investigated task‐switching with ‘univalent’ stimuli affording responses in only one of the tasks, and compared the outcomes to those recently obtained with bivalent stimuli (Lavric et al. [ 2008 ]: Eur J Neurosci 1‐14), in order to examine two phenomena. First, when only univalent stimuli are presented, the processing of task cues becomes optional. Our results showed that in these circumstances linguistic (but not pictorial) cues were still effective in eliciting at least some degree of preparation for a task‐switch, as evidenced by the reduction in the error cost of switching at the longer preparation interval and by a posterior switch‐induced ERP positivity at about 450–800 ms in the cue‐stimulus interval. Second, single affordance stimuli not only reduced behavioural switch costs relative to bivalent stimuli; they also produced a smaller post‐stimulus switch‐induced negativity, consistent with the latter being a marker of conflict between task‐sets. However, using stimuli not associated with responses in the alternative task did not completely eliminate the negativity. We speculate that the residue reflects other sources of conflict: attention to the irrelevant perceptual dimension and/or persistence of task goals. Hum Brain Mapp, 2011. © 2011 Wiley‐Liss, Inc.
Vascularized composite allografts and solid organ transplants: similarities and differences

Purpose of reviewVascularized composite allotransplantation (VCA) is a treatment for complex tissue injuries and defects of extremities and face. During the past thirteen years, more than 100 VCA cases have been reported. Form and function restored with VCA have exceeded the results achieved with conventional surgical techniques. The review summarized the development in VCA over the past 12 months with references of and comparison with solid organ transplantation. Recent findingsThe highlights reported in the latest publications included a better understanding of topical immunosuppressants for prevention and treatment of VCA rejection, mechanisms of chronic rejection and minimization of immunosuppressive maintenance treatment using a cell-based protocol in human upper-extremity transplantation. SummaryWe herein summarize the progress made in VCA in the last year with a focus on new clinical immunosuppressive strategies and novel targets for immunosuppression and immunomodulation including the application of mesenchymal stem cells for transplant tolerance.
Mining Key Skeleton Poses with Latent SVM for Action Recognition

Human action recognition based on 3D skeleton has become an active research field in recent years with the recently developed commodity depth sensors. Most published methods analyze an entire 3D depth data, construct mid-level part representations, or use trajectory descriptor of spatial-temporal interest point for recognizing human activities. Unlike previous work, a novel and simple action representation is proposed in this paper which models the action as a sequence of inconsecutive and discriminative skeleton poses, named as key skeleton poses. The pairwise relative positions of skeleton joints are used as feature of the skeleton poses which are mined with the aid of the latent support vector machine (latent SVM). The advantage of our method is resisting against intraclass variation such as noise and large nonlinear temporal deformation of human action. We evaluate the proposed approach on three benchmark action datasets captured by Kinect devices: MSR Action 3D dataset, UTKinect Action dataset, and Florence 3D Action dataset. The detailed experimental results demonstrate that the proposed approach achieves superior performance to the state-of-the-art skeleton-based action recognition methods.