Miracle-dz/UniFAR-FTUs huggingface dataset:
A Cerebral Network Reflecting Reorganization in Medial Temporal Lobe Epilepsy

Hippocampal sclerosis in temporal lobe epilepsy (TLE) is often associated with hippocampal atrophy. This study assessed whether such atrophy is correlated with loss of gray matter volume in other brain regions. In 16 patients with TLE and clear magnetic resonance imagingbased evidence of hippocampal sclerosis, hippocampal volumes were determined manually, and the local gray matter (LGM) amount was estimated throughout the entire brain using voxel-based morphometry. Voxelwise correlations between the volume of the sclerotic hippocampus and LGM were computed. The pattern of voxels whose LGM correlated with hippocampal volume outlined remarkably well the anatomy of the extended limbic system and included the parahippocampal region, cingulate gyrus throughout its extent, basal forebrain, thalamic nuclei, medial orbitofrontal areas, and the insula. These correlations emerged mainly on the side ipsilateral to the affected hippocampus but were also found contralaterally. No such correlations were found in a group of 16 healthy controls. The present data show that hippocampal volume loss in TLE is associated with a widespread limbic systems atrophy. These findings are helpful to better understand the functional deficit and reorganization often found in temporal lobe epilepsy and will also provide a basis to assess neural plasticity in the limbic system for those patients who will undergo curative temporal lobe surgery.
Craniospinal Pressure–Volume Dynamics in Phantom Models

Regulation of intracranial pressure (ICP) is vital to proper brain function. Pathologic conditions such as traumatic brain injury and hydrocephalus can cause lethal changes in ICP through an imbalance of fluid passage into and out of the craniospinal space. The relationship between craniospinal volume and pressure determines to a large extent whether such imbalance can be compensated or if it will lead to neuronal damage. Phantom models are predisposed for the evaluation of medical procedures and devices that alter volume in the spinal or cranial space. However, current phantoms have substantial limitations in the reproduction of craniospinal pressure-volume relationships, which need to be overcome prior to their deployment outside the basic research setting. We present herein a novel feedback controlled phantom for the reproduction of any physiologic or pathologic pressure-volume relation. We compare its performance to those of existing passive methods, showing that it follows reference curves more precisely during both infusion of large volumes and fast oscillatory volume changes.
A Framework to Build Bayesian Networks to Assess Scrum-based Software Development Methods

Agile software development has been increasingly used to satisfy the need to respond to fast moving market demand and gain market share. Scrum, which is a project management framework, dominates as the most popular agile method. In the literature, there are a number of solutions to customize and assess Scrum-based agile methods, but they are limited to focus only on process factors, assume a predefined set of practices or rely only on subjective evaluation. This paper presents a framework to build a Bayesian Network to assist on the assessment of Scrum-based software development methods. The BN models the main entities of the software development process and can be complemented with software practices and metrics. To evaluate the completeness of our solution, we performed simulations to check if the proposed framework diagnoses 14 known Scrum anti-patterns extracted from the literature. 12 antipatterns were directly detected, 1 was indirectly detected by the BN and 1 was considered as invalid. We concluded that the proposed solution is complete to detect the major flaws of Scrum-based software development methods and can be used to assist on the configuration, adoption and continuous improvement of Scrum teams.
Made-to-Measure Technologies for an Online Clothing Store

The Internet is a compelling channel for selling garments. Several recent initiatives by companies such as Nordstrom, Macy's, and Lands End focus on made-to-measure manufacturing and shopping via the Internet. We present a Web application that provides more powerful access to and manipulation of clothing to facilitate clothing design, pattern derivation, and sizing. We apply 3D graphics technology to help create and simulate the virtual store.
Extending energy-saving voltage scaling in ultra low voltage integrated circuit designs

In this paper, we propose several design approaches to extend useful voltage scaling (i.e. voltage scaling with net energy savings) beyond the conventional limit, which is imposed by the rapid increase of leakage energy overhead in ultra low voltage regimes. We are able to achieve such extra voltage scaling and thus energy savings without compromising performance and variability through minimizing the ratio of leakage to dynamic energy in a circuit. Novel design approaches in pipeline, clocking and architecture optimization are investigated; and applied during the design of a 16b 1024pt complex FFT core. The measurement results from the prototyped FFT core in a 65nm CMOS show the energy consumption of 15.8nF/FFF with the clock frequency of 30MHz and the throughput of 240Msamples/s at the supply voltage of 270mV, which exhibits 2.4× higher energy efficiency and >;10× higher throughput than the previous low power FFT designs. Measurement of 60 dies shows modest frequency and energy σ/μ spreads of 7% and 2%, respectively.
Needle Perforations of Molteno Tubes

PurposeTo investigate the effects of needle perforation of proximal Molteno tubes on intraluminal pressure in a constant flow system. Materials and MethodsBalanced salt solution was infused at a rate of 2 &mgr;L/min through nonexpansile silicon tubing attached to a manometric reservoir, pressure transducer, and an occluded proximal Molteno glaucoma drainage device tube. As the intraluminal pressure rose to approximately 30 mm Hg, the tube was perforated once with needles ranging in size from 23G to 29.5 G (disposable insulin syringe). Intraluminal pressure was measured continuously throughout each test run for an average of 71 minutes each. ResultsThe average stable intraluminal pressure ranged from 25 mm Hg for 29.5-G perforation to 15 mm Hg for 23-G perforation. The lowest single pressure recorded ranged from 3 mm Hg for 23-G perforations to 17 mm Hg for 29.5-G perforations. Pressures of less than 15 mm Hg were recorded in more than 60% of the 23-G and 25-G perforations, less than 20% of the 27-G perforations, and none of the 29.5-G perforations. ConclusionAt a flow rate of 2&mgr;L/min of balanced salt solution, 23-G and 25-G needle perforations of silicone glaucoma drainage device tubes produce intraluminal pressures in vitro, which may result in low intraocular pressures. Immediate postoperative hypotony risk can be reduced if a smaller needle perforation is used.
Designing for performative interactions in public spaces

Building on the assumption that every human action in public space has a performative aspect, this workshop seeks to explore issues of mobile technology and interactions in public settings. We will examine the design of performative technologies, the evaluation of user experience, the importance of spectator and performer roles, and the social acceptability of performative actions in public spaces. The workshop will aim to bring together researchers and practitioners who are interested in the rapidly growing area of technologies supporting use in a public setting, and through this, explore the themes the workshop offers, plan for publications which synthesize together this disparate work, and finally to facilitate future collaborations between participants.
Characteristics showing the ubiquity of software projects

An “everyware world” as Adam Greenfield calls it, is a world in which computers are embedded and merged seamlessly everywhere with the environment. Radio frequency and data identification communicates their position and other location information constantly in a vast file network. Everyday objects become searchable if they are part of interconnected World Wide Web. Looking into last three decades, the 80s was the decade of the microprocessors symbolized by the personal computer when computers were built, the 90s was the decade of networks and communication symbolized by the World Wide Web where computers were connected together. Finally in this decade, it is computer that is present everywhere, connected to almost everything and embedded in every little thing. It is known that the ubiquitous computing arrived when we realized invisibility of computers. Despite of many upgradations in software engineering field, the emerging of ubiquitous software still represents a grand challenge. So basically this paper intimates about the essential characteristics of ubiquitous computing in some of the ubiquitous software projects. And these characteristics are further organized, formulated and represented in such a way that they reveal the ubiquity of projects by estimating their presence or absence.
Alternative structures for character-level RNNs

Recurrent neural networks are convenient and efficient models for language modeling. However, when applied on the level of characters instead of words, they suffer from several problems. In order to successfully model long-term dependencies, the hidden representation needs to be large. This in turn implies higher computational costs, which can become prohibitive in practice. We propose two alternative structural modifications to the classical RNN model. The first one consists on conditioning the character level representation on the previous word representation. The other one uses the character history to condition the output probability. We evaluate the performance of the two proposed modifications on challenging, multi-lingual real world data.
State feedback control of current type PWM AC-to-DC converters

A control method of current type PWM AC-to-DC converters which realize sinusoidal AC input current and unity power factor is discussed. In such a type of converter, an LC filter required on the AC side may cause a resonant problem especially in the transient condition. To overcome this problem, state feedback control is introduced, and a control strategy which is suitable for the DC output current control as well as the AC side current control is proposed. Circuit parameters and feedback coefficients in the AC side current control system are optimized on the basis of an analysis in which the system is treated as a sampled data system. This system is applied to current pattern control of a reactor. <<ETX>>
E-Government implementation Challenges: A Case study

The purpose of this paper is to explore empirically the implementation of e-government in a developing country in the Gulf Cooperation Countries (GCC) and the key challenges that influence implementation. A case study (using interview-based research) was undertaken within the State of Qatar. After reviewing the available literature, the paper first proposes a conceptual model, which was then used to explore e-government related change by considering the key forces influencing implementation from an organisational, technological, social and political context. The empirical results confirmed previously findings in literature and identified a number of new issues that were influencing e-government implementation in Qatar which were not explicitly discussed in prior e-government research.
Bilateral depth-discontinuity filter for novel view synthesis

In this paper, a new filtering technique addresses the disocclusions problem issued from the depth image based rendering (DIBR) technique within 3DTV framework. An inherent problem with DIBR is to fill in the newly exposed areas (holes) caused by the image warping process. In opposition with multiview video (MVV) systems, such as free viewpoint television (FTV), where multiple reference views are used for recovering the disocclusions, we consider in this paper a 3DTV system based on a video-plus-depth sequence which provides only one reference view of the scene. To overcome this issue, disocclusion removal can be achieved by pre-processing the depth video and/or post-processing the warped image through hole-filling techniques. Specifically, we propose in this paper a pre-processing of the depth video based on a bilateral filtering according to the strength of the depth discontinuity. Experimental results are shown to illustrate the efficiency of the proposed method compared to the traditional methods.
Screening for cryptic chromosomal abnormalities in patients with mental retardation and dysmorphic facial features using telomere fish probes

Three recently published large studies have identified subtelomeric rearrangements in 4 to 9% of individuals with idiopathicmental retardationusingFISH telomere probes [Anderlid et al., 2002; Baker et al., 2002; Clarkson et al., 2002]. Previous telomere studies have shown that cryptic deletions andduplications not visible by routine G-band analysis can occur in up to 7.5% of patients with moderate to severe mental retardation using telomerefluorescence in situhybridization (FISH) probes [Knight et al., 1999; Slavotinek et al., 1999; Rossi et al., 2001]. We initiated a similar IRB-approved study, after receiving parental informed consent, on patients who had mental retardation or developmental delay and dysmorphic facial features, as identified by a clinical geneticist. Among the 17 patients enrolled in the study, three cases had visible cytogenetic abnormalities and one had a single gene mutation. Of the remaining 13 cases studied using FISH telomere probes (Cytocell, Oxfordshire, UK), three abnormal telomere results were found; del(1)(p36.3), der(1)t(1;8)(p36.3;p23), and del(2)(q37). The 1p deletion was confirmed using amore proximal probe, p 58 (Oncor, Gaithersburg, MD). Both parental karyotypes were normal. For the second patient, one of the 8p telomere probe signals showed a split signal between 8p and 1p, the latter which also had a 1p telomere signal. The 8p telomere probe can crosshybridize with 1p, as currently listed on the Cytocell website. As a follow-up, parental blood samples were obtained, and the father’s chromosomes showed the same hybridization pattern for the 8p probe as the child’s, suggesting an inherited polymorphism. For the third patient, the Vysis (Downers Grove, IL) 2q telomere probe, which is proximal to the Cytocell probe, was present on both homologues. This polymorphism has been reported [Ballif et al., 2000] and acknowledged by Cytocell. Our study identified a cryptic chromosomal abnormality in 1/13 or 7.7% (95%C.I., 0.2–36%) of patientswith idiopathic mental retardation and abnormal facial appearance. These results are similar to larger studies that have been reported. Our study emphasizes the importance of confirming the abnormality in the child and parents, using different telomere probes since cross hybridization and polymorphisms exist. In addition, these studies have helped identify recognizable syndromes, including the del(1)(p36.3), which has been identified as a deletion syndrome [Reish et al., 1995], and recently has been estimated to be as frequent as 1/5,000 [Ballif et al., 2001]. Collection of this type of information can help to provide prognostic information to parents.
Performance of Foldcores Mechanical Properties and Testing

Foldcores are folded open cellular structures which are currently under development at Institute of Aircraft Design (IFB). The IFB has generated an integrated manufacturing process to produce foldcores, starting with the mathematical methods to design the required foldcore geometry to the point of realizing them in an automated and continuous fashion. By isometric folding of planar base materials foldcores can and have already been manufactured out of a large variety of materials: cardboard, papers, metals (aluminum, steel, titanium), different thermoplastic films (PC, PVC, PPSU, PEEK) as well as advanced fibre reinforced materials (glass, carbon, aramid fibres). For the technical use of foldcores in sandwich structures it is necessary to supply a competitive level of mechanical performance. We discuss the mechanical properties of foldcores compared to other state of the art core materials. We detail the testing methods used to determine compression and shear strengths and stiffnesses, which are based upon international standards. Evaluation of the test results show potential for the use of foldcores in high performance lightweight structures, especially considering their unique multifunctional applicability.Copyright © 2013 by ASME
Learning an Operant Conditioning Task Differentially Induces Gliogenesis in the Medial Prefrontal Cortex and Neurogenesis in the Hippocampus

Circuit modification associated with learning and memory involves multiple events, including the addition and remotion of newborn cells trough adulthood. Adult neurogenesis and gliogenesis were mainly described in models of voluntary exercise, enriched environments, spatial learning and memory task; nevertheless, it is unknown whether it is a common mechanism among different learning paradigms, like reward dependent tasks. Therefore, we evaluated cell proliferation, neurogenesis, astrogliogenesis, survival and neuronal maturation in the medial prefrontal cortex (mPFC) and the hippocampus (HIPP) during learning an operant conditioning task. This was performed by using endogenous markers of cell proliferation, and a bromodeoxiuridine (BrdU) injection schedule in two different phases of learning. Learning an operant conditioning is divided in two phases: a first phase when animals were considered incompletely trained (IT, animals that were learning the task) when they performed between 50% and 65% of the responses, and a second phase when animals were considered trained (Tr, animals that completely learned the task) when they reached 100% of the responses with a latency time lower than 5 seconds. We found that learning an operant conditioning task promoted cell proliferation in both phases of learning in the mPFC and HIPP. Additionally, the results presented showed that astrogliogenesis was induced in the medial prefrontal cortex (mPFC) in both phases, however, the first phase promoted survival of these new born astrocytes. On the other hand, an increased number of new born immature neurons was observed in the HIPP only in the first phase of learning, whereas, decreased values were observed in the second phase. Finally, we found that neuronal maturation was induced only during the first phase. This study shows for the first time that learning a reward-dependent task, like the operant conditioning, promotes neurogenesis, astrogliogenesis, survival and neuronal maturation depending on the learning phase in the mPFC-HIPP circuit.
A Reformed Corrosion Cast Technique using Commercially Available Polyvinyl Chloride Solution

Corrosion cast technique has advanced since its first application using wax by Leonardo da Vinci in 16 th century. Various materials such as metal alloys, celloidin, latex gum, synthetic resins/epoxy resins, polyester resins, and silicone have been used to prepare cast of vasculature and ductal architecture. However, the current reformed technique as described used commercially available polyvinyl chloride (PVC) solution to prepare cast of vascular/ductal anatomy. This technique being cost-effective and rapid can be easily applied in low resource situation. The Department of Anatomy Maulana Azad Medical College, New Delhi standardized this technique to prepare corrosion casts using PVC solution and is regularly training participants in the annual workshop on "body preservation techniques on embalming plastination and musemology" conducted by the Department.
Track : XML and Web Data Session : Parsing , Normalizing , and Storing XML 1073

As XML database sizes grow, the amount of space used for storing the data and auxiliary data structures becomes a major fa ctor in query and update performance. This paper presents a new st orage scheme for XML data that supports all navigational opera tions in near constant time. In addition to supporting efficient qu eries, the space requirement of the proposed scheme is within a cons tant factor of the information theoretic minimum, while inserti ons and deletions can be performed in near constant time as well. As a result, the proposed structure features a small memory footpr int that increases cache locality, whilst still supporting standar d APIs, such as DOM, and necessary database operations, such as queries a nd updates, efficiently. Analysis and experiments show that th e proposed structure is space and time efficient.
The TUM walking machines

This paper presents some aspects of walking machine design with a special emphasis on the three machines MAX, MORITZ and JOHNNIE, having been developed at the Technical University of Munich within the last 20 years. The design of such machines is discussed as an iterative process improving the layout with every iteration. The control concepts are event-driven and follow logical rules, which have largely been transferred from neurobiological findings. At least for the six-legged machine MAX, a nearly perfect autonomy could be achieved, whereas for the biped JOHNNIE, a certain degree of autonomy could be realized by a vision system with appropriate decision algorithms. This vision system was developed by the group of Prof. G. Schmidt, TU-München. A more detailed description of the design and realization is presented for the biped JOHNNIE.
Identification of a Gephyrin-Binding Motif in the GDP/GTP Exchange Factor Collybistin

Abstract The brainspecific GDP/GTP exchange factor collybistin interacts with the receptoranchoring protein gephyrin and activates the Rholike GTPase Cdc42, which is known to regulate actin cytoskeleton dynamics. Alternative splicing creates two collybistin variants, I and II. In coexpression experiments, collybistin II has been shown to induce the formation of submembraneous gephyrin aggregates which cluster with heterooligomeric glycine receptors (GlyRs). Here we identified residues critical for interaction with gephyrin in the linker region between the SH3 and the DH domains of collybistin. Respective collybistin deletion mutants failed to bind gephyrin upon coexpression in heterologous cells, in GST pulldown assays and in the yeast twohybrid system. Sitedirected mutagenesis revealed polar amino acid residues as essential determinants of gephyrin binding. Furthermore, in vitro gephyrin bound simultaneously to both collybistin and the GlyRβsubunit binding motif. Our data are consistent with collybistingephyrin interactions occuring during inhibitory postsynaptic membrane formation.
Ferritic stainless steel welding with the A-TIG process

The main advantage of the TIG with flux process (A-TIG welding) is the possibility of obtaining greater penetration of the weld bead while employing the same welding parameters as conventional TIG welding. Various studies have shown the influence of active fluxes on the geometric characteristics of stainless steel austenitic welds. However, little is known about the influence of this process on the geometric and metallurgical characteristics of the weld beads in ferritic stainless steels. In this work, different types of flux are applied when welding ferritic stainless steel with the objective of verifying possible influences on the weld bead's profile, on its visual appearance, on the microstructure, on the hardness of the welded zone and on the impact resistance (Charpy test). The bead-on-plate welds were produced without using any addition metal. Six types of flux were used – one being an oxide produced in a laboratory (TiO2) and five commercial fluxes. The results showed that use of the flux allows an increase in penetration with significant changes in the appearance of the weld bead. It was also confirmed that the microstructure and the hardness of the weld bead for the steel studied were not affected by the type of flux used, with the microstructure analysed under an optical microscope. The steel in the study showed a high degree of fragility at ambient temperature.