Miracle-dz/UniFAR-FTUs huggingface dataset:
FATORES DE RETENÇÃO, PERMANÊNCIA E DESLIGAMENTO DE TALENTOS E DE PERFORMERS / Factors that influence talents’ and performers’ retention, permanence and decision to leave the company

Este estudo buscou identificar fatores organizacionais que podem influenciar profissionais considerados talentos, pertencentes as geracoes baby boomers, X e Y, quanto a sua permanencia ou efetiva intencao de deixar a organizacao. A pesquisa utilizou o metodo do estudo de caso e adotou estrategia quantitativa e qualitativa na coleta e analise dos dados. O estudo foi realizado em uma organizacao do ramo da fabricacao do aco. Os principais fatores de retencao analisados foram o ambiente organizacional, a configuracao do trabalho, as condicoes de trabalho, a gestao do lider, a carreira, a remuneracao total, a capacitacao e o desenvolvimento. Na primeira etapa da pesquisa, um questionario eletronico foi respondido por 212 empregados e a analise dos resultados ocorreu por meio da estatistica multivariada. Na segunda etapa, foi utilizada a entrevista semiestruturada, sendo sujeitos da pesquisa 10 empregados representantes das geracoes baby boomers, X e Y. Nessa etapa, os dados foram analisados por meio da tecnica de analise de conteudo, por categoria tematica, em razao de temas considerados relevantes. Quanto aos resultados, verificou-se que nao existe um unico fator de influencia na retencao, mas um conjunto de fatores que leva os individuos a permanecer na organizacao e que sua ausencia colabora significativamente com sua intencao de saida. Evidenciou-se a nao existencia de diferencas significantes entre as tres geracoes pesquisadas no que se refere aos fatores de impacto na retencao, na permanencia e na intencao de saida.Palavras-chave: Retencao. Talento. Geracoes.
Evolution and Transmission of Respiratory Syncytial Group A (RSV-A) Viruses in Guangdong, China 2008–2015

Respiratory syncytial viruses (RSVs) including subgroups A (RSV-A) and B (RSV-B) are an important cause of acute respiratory tract infections worldwide. RSV-A include major epidemic strains. Fundamental questions concerning the evolution, persistence and transmission of RSV-A are critical for disease control and prevention, yet remain unanswered. In this study, we generated 64 complete G gene sequences of RSV-A strains collected between 2008 and 2015 in Guangdong, China. Phylogenetic analysis was undertaken by incorporating 572 publicly available RSV-A sequences. Current data indicate that genotypes GA1, GA4, and GA5 are endemic with limited epidemic activity. In contrast, the GA2 genotype which likely originated in 1980 has spread rapidly and caused epidemics worldwide. By analyzing GA2 genotype sequences across epidemic seasons within Guangdong, we find that RSV-A epidemics in Guangdong are caused by a combination of virus importation and local persistence, although the magnitude of the latter is likely overestimated due to infrequent sampling in other regions. Our results provide new insights into RSV-A evolution and transmission at global and local scales and highlights the rapid and wide spread of genotype GA2 compared to other genotypes. In order to control RSV transmission and outbreak, both local persistence and external introduction should be taken into account when designing optimal strategies.
The factors affecting effectiveness of treatment in phages therapy

In recent years, the use of lytic bacteriophages as antimicrobial agents controlling pathogenic bacteria has appeared as a promising new alternative strategy in the face of growing antibiotic resistance which has caused problems in many fields including medicine, veterinary medicine, and aquaculture. The use of bacteriophages has numerous advantages over traditional antimicrobials. The effectiveness of phage applications in fighting against pathogenic bacteria depends on several factors such as the bacteriophages/target bacteria ratio, the mode and moment of treatment, environmental conditions (pH, temperature.), the neutralization of phage and accessibility to target bacteria, amongst others. This report presents these factors and the challenges involved in developing phage therapy applications.
Visual Characterisation of Colon Images

This paper describes a pilot study investigating the potential of metrics based on low-level processes underlying form perception in human vision to differentiate between normal and cancerous tissue in histopathological images of colon. We also discuss possibilities for further visual characterisation of these images in terms of low-level visual processes and their relationship to domain based knowledge developed through clinical training.
Semantic Selectional Restrictions for DisambiguatingMeronymy Relations : A non-representational DRT-like discourse semantics

In this paper, we present an unsupervised approach to automatically learn lexico-syntactic patterns encoding meronymy relations from texts. Our major contribution lies in alleviating the challenge of disambiguating polysemous patterns that encode meronymy only in some contexts. We rely on the linking theory to posit that semantic features of the Part and Whole instances participating in a meronymy relation facilitate the identification of meronymy-encoding patterns. We abstract the instances to their hypernyms, enforcing semantic selectional restrictions to constrain the contexts within which patterns participate in meronymy. We disambiguate polysemous patterns using their contexts based on a modified version of Harris’ distributional hypothesis by postulating that similar patterns share similar contexts. Our experiments revealed that enforcing semantic selectional restrictions to constrain the contexts within which patterns participate in meronymy leads to the identification of high-quality patterns. Furthermore, our method does not require annotated data, and has a broader coverage compared to previous studies.
A Transformation Approach for Classifying ALCHI(D) Ontologies with a Consequence-based ALCH Reasoner

Consequence-based techniques have been developed to provide efficient classification for less expressive languages. Ontology transformation techniques are often used to approximate axioms in a more expressive language by axioms in a less expressive language. In this paper, we present an approach to use a fast consequence-based ALCH reasoner to classify anALCHI(D) ontology with a subset of OWL 2 datatypes and facets. We transform datatype and inverse role axioms intoALCH axioms. The transformed ontology preserves sound and complete classification w.r. t the original ontology. The proposed approach has been implemented in the prototype WSClassifier which exhibits the high performance of consequence reasoning. The experiments show that for classifying large and highly cyclic ALCHI(D) ontologies, WSClassifier’s performance is significantly faster than tableau-based reasoners.
reality: a Scalable Intelligent Travel Planner. Decision Support for the Business Traveler

Many information systems are used in a problem solving context. Examples are travel planning systems, catalogs in electronic commerce, or agenda planning systems. They can be made more useful by integrating problem-solving capabilities into the information systems. This poses the challenge of scalability: when hundreds of users access a server at the same time, it is important to avoid excessive computational load. In this paper, we present an approach, called reality, that allows to significantly extend the reach of electronic commerce in travel. Our application addresses in particular the challenge of modeling customers’ personal preferences and providing solutions that are tailored to just those preferences. In contrast to existing technology, which allow to optimize only a small and predefined set of preferences, our tool allows a wide variety that can accurately model the preferences of different customers.
[Roles of the central nucleus of amygdala in the cardiovascular response elicited by the paraventricular nucleus of hypothalamus].

OBJECTIVE To investigate the cardiovascular responses induced by activation of the paraventricular nucleus of hypothalamus (PVN) and the roles of the central nucleus of amygdala (CeA) on this effect. METHODS The PVN was activated by microinjection of L-glutamate or electrical stimulation. The CeA was injected with L-glutamate or Kainic acid (KA). The femoral arterial pressure, mean arterial pressure (MAP), electrocardiogram (ECG) and heart rate (HR) of the male SD rats were recorded when the PVN was electrically stimulated. RESULT The blood pressure increased when the PVN was activated either by electrical current or by L-glutamate. The blood pressure increased for (10.27+/-1.80)mmHg and the change of heart rate was -10.66 +/- 8.11 beat/min after L-Glu (100 nl) was injected into the ipsilateral CeA. The pressor response of PVN stimulation could still be evoked by electrical stimulation of (13.78 +/- 3.18)mmHg 10 min after kainic acid (100 nl) was injected into the ipsilateral CeA. But this pressor response decreased of 6.57 mmHg compared to that before injection of KA (P <0.05). The locations of the electrode tips and termination of the injector tracts were identified according to the atlas after the recording. CONCLUSION Stimulating the PVN elicits pressor response in rats. The CeA mediates partly the pressor response elicited by activation of the PVN.
Comparison of Intracellular “Ca. Endomicrobium Trichonymphae” Genomovars Illuminates the Requirement and Decay of Defense Systems against Foreign DNA

“Candidatus Endomicrobium trichonymphae” (Bacteria; Elusimicrobia) is an obligate intracellular symbiont of the cellulolytic protist genus Trichonympha in the termite gut. A previous genome analysis of “Ca. Endomicrobium trichonymphae” phylotype Rs-D17 (genomovar Ri2008), obtained from a Trichonympha agilis cell in the gut of the termite Reticulitermes speratus, revealed that its genome is small (1.1 Mb) and contains many pseudogenes; it is in the course of reductive genome evolution. Here we report the complete genome sequence of another Rs-D17 genomovar, Ti2015, obtained from a different T. agilis cell present in an R. speratus gut. These two genomovars share most intact protein-coding genes and pseudogenes, showing 98.6% chromosome sequence similarity. However, characteristic differences were found in their defense systems, which comprised restriction-modification and CRISPR/Cas systems. The repertoire of intact restriction-modification systems differed between the genomovars, and two of the three CRISPR/Cas loci in genomovar Ri2008 are pseudogenized or missing in genomovar Ti2015. These results suggest relaxed selection pressure for maintaining these defense systems. Nevertheless, the remaining CRISPR/Cas system in each genomovar appears to be active; none of the “spacer” sequences (112 in Ri2008 and 128 in Ti2015) were shared whereas the “repeat” sequences were identical. Furthermore, we obtained draft genomes of three additional endosymbiotic Endomicrobium phylotypes from different host protist species, and discovered multiple, intact CRISPR/Cas systems in each genome. Collectively, unlike bacteriome endosymbionts in insects, the Endomicrobium endosymbionts of termite-gut protists appear to require defense against foreign DNA, although the required level of defense has likely been reduced during their intracellular lives.
Dramatic effects of hydrogen-induced out-diffusion of oxygen from Ge surface on junction leakage as well as electron mobility in n-channel Ge MOSFETs

This paper discusses about effects of oxygen in Ge substrate on MOSFET performance from both viewpoints of advantages and disadvantages. For improvement of electron mobility in Ge n-MOSFETs, oxygen in the channel region should be extracted to suppress additional scattering. On the other hand, oxygen in S/D region is helpful for dramatically reducing junction leakage currents. By understanding these oxygen effects on Ge, high electron mobility Ge n-MOSFETs with the highest Ion/Ioff ratio are demonstrated.
Carotenoids from Marine Microalgae: A Valuable Natural Source for the Prevention of Chronic Diseases

Epidemiological studies have shown a relation between antioxidants and the prevention of several chronic diseases. Microalgae are a potential novel source of bioactive molecules, including a wide range of different carotenoids that can be used as nutraceuticals, food supplements and novel food products. The objective of this review is (i) to update the research that has been carried out on the most known carotenoids produced by marine microalgae, including reporting on their high potentialities to produce other less known important compounds; (ii) to compile the work that has been done in order to establish some relationship between carotenoids and oxidative protection and treatment; (iii) to summarize the association of oxidative stress and the various reactive species including free radicals with several human diseases; and (iv) to provide evidence of the potential of carotenoids from marine microalgae to be used as therapeutics to treat or prevent these oxidative stress-related diseases.
Lower Bounds on Learning Decision Lists and Trees

k-decision lists and decision trees play important roles in learning theory as well as in practical learning systems, k-decision lists generalize classes such as monomials, k-DNF, and k-CNF and like these subclasses is polynomially PAC-learnable [19]. This leaves open the question of whether k-decision lists can be learned as efficiently as k-DNF. We answer this question negatively in a certain sense, thus disproving a claim in a popular textbook [2]. Decision trees, on the other hand, are not even known to be polynomially PAC-learnable, despite their widespread practical application. We will show that decision trees are not likely to be efficiently PAC-learnable. We summarize our specific results.
Analysis of Product Rollover Strategies in the Presence of Strategic Customers

Frequent product introductions emphasize the importance of product rollover strategies. With single rollover, when a new product is introduced, the old product is phased out from the market. With dual rollover, the old product remains in the market along with the new product. Anticipating the introduction of the new product and the potential markdown of the old product, strategic customers may delay their purchases. We study the interaction between product rollover strategies and strategic customer purchasing behavior and find that single rollover is more valuable when the new product's innovation is low and the number of strategic customers is high. Interestingly and counter to intuition, the firm may have to charge a lower price for the old product as well as receive a lower profit with a higher value disposal (outside) option for the old product under single rollover. Facing a market composed of both strategic and myopic customers, the firm does not necessarily reduce the stocking level as more myopic customers become strategic. This paper was accepted by Yossi Aviv, operations management.
DNA-methylation changes in replicative senescence and aging: two sides of the same coin?

Replicative senescence is often considered to be a hallmark of aging [1] – but this assumption needs to be challenged by new insights into associated epigenetic modifications. Primary cells can undergo only a limited number of cell divisions in vitro before they enter the state of replicative senescence, which is reflected by unequivocal cell cycle arrest. It was first described half a century ago by Leonard Hayflick [2] – therefore often referred to as ‘Hayflick limit’ – and since then it has been speculated that replicative senescence is tightly associated with aging of the organism [3]. In fact, cellular aging during in vitro culture reflects various molecular features that seem to be indicative for aging, such as telomere attrition, activation of the p53/p21CIP1 and p16INK4A/pRb signaling pathways, alteration of cell morphology and metabolism, increased senescence-associated β-galactosidase activity, loss of differentiation potential, formation of senescence-associated heterochromatin foci and the senescenceassociated secretory phenotype [1]. Cell samples from elderly donors recapitulate many of these parameters, including a higher number of positive staining for senescence-associated β-galactosidase [4]; slower proliferation rate and senescence-like morphological changes already at the initial cell passage [5]; reduced colony-forming unit frequency [6] and concordant gene expression changes [7]. These findings fueled the perception, that replicative senescence in vitro and aging in vivo are governed by the same conserved mechanism – although carried out at a different pace. Cellular changes in the course of culture expansion are therefore often considered as a good in vitro model to unravel the molecular mechanisms that drive the process of aging. Replicative senescence and aging are both reflected by highly reproducible epigenetic changes – particularly in the DNA methylation (DNAm) pattern of developmental genes [8]. DNAm is nowadays the best-characterized epigenetic modification: it represents a covalent addition of methyl groups to cytosine residues in the context of CG dinucleotides, referred to as ‘CpG site. ’ Senescence-associated DNAm changes are significantly enriched in genomic regions with repressive histone marks (H3K9me3 and H3K27me3) and at target sites of Polycomb group proteins [9,10]. Similar findings have also been reported for age-associated DNAm changes [11,12]. In fact, direct correlation of age-associated and senescenceassociated DNAm changes in mesenchymal stromal cells (MSCs) revealed a moderate but significant association of the two epigenetic processes [8]. On the other hand, replicative senescence and aging can both be tracked by very specific epigenetic modifications: for example, an ‘epigenetic-senescence-signature’ DNA-methylation changes in replicative senescence and aging: two sides of the same coin?
Investigation of Adolescent Mobile Phone Addiction by Social Anxiety Effect of Some Variable

The aim of the research is to evaluate the operation on adolescents' social anxiety level of the mobile phone addiction. Social anxiety levels and examining the increasing degree on the social concerns surrounding the use of telephone adolescents every moment of our lives, and their age, sex, has investigated how variation depending on factors such as education. Research has primarily social anxiety of adolescence and then to look at the concept stage of development and especially denial thought to be due to certain fundamental features of mobile phone addiction. Then the mobile phone addiction in adolescents 14-18 years of age after the stages of mobile phone addiction investigated by perceived levels of social anxiety in order to investigate whether there was a significant relationship "relational model" is used. In the study, individuals prepared by the researcher to identify some of the personal characteristics Personal Information Form, Social Anxiety Scale and Problem of Cell Phone Use Scale is used.
Long-term outcome after thrombolysis in telemedical stroke care

Background: IV thrombolysis represents the most effective acute stroke therapy. However, it is almost exclusively performed in stroke centers and is not available in most community areas. The Telemedical Pilot Project for Integrative Stroke Care (TEMPiS) was started in February 2003. Twelve community hospitals with no or very limited stroke thrombolysis experience and two stroke centers were connected via a network providing online neurologic examination and transfer of neuroradiologic scans. Following recently published preliminary results on acute phase safety of telethrombolysis, the present study reports on its long-term functional outcome. Methods: Modified Rankin Scale (mRS), Barthel Index (BI), and mortality rate were prospectively collected 3 and 6 months after IV thrombolysis in patients of community network hospitals (telemedical group) and the stroke centers. Values of 95/100 for the BI and 0/1 for the mRS were defined as a favorable outcome. Results: Over the first 22 months, 170 patients were treated with tPA in the telemedical hospitals and 132 in the stroke center hospitals. Mortality rates were 11.2% vs 11.5% at 3 months (p = 0.55) and 14.2% vs 13% at 6 months (p = 0.45). A good functional outcome after 6 months was found in 39.5% of the telemedical hospitals vs 30.9% of the stroke centers (p = 0.10) for the mRS and 47.1% vs 44.8% (p = 0.44) regarding the BI. Conclusions: Mortality rates and functional outcomes for telemedicine-linked community hospitals and stroke centers were similar and comparable to the results from randomized trials.
Stochastic impact assessment of the heating and transportation systems electrification on LV grids

According to the new energy policy agreements, a conceptual and technological re-structuration of the Danish energy sector is expected. One of the key points for its successful implementation is the partial electrification of the heating and transportation systems. This fact, which reflects an enormous load increase, influences already the design and planning of the future power system. Great percentage of this new load is expected to be accommodated at local distribution level. Therefore, it implies that the distribution system operator will have to handle an increasing number of highly rated loads in networks which were not designed for them. In low voltage grids especially, depending on the system penetration grade and the way they are disposed produces a completely different reaction of the network. This paper introduces a methodology for stochastically evaluating the impact caused by thermostatic and plug-in electric vehicle loads in low voltage grids. On one hand, it defines which the potential bottlenecks of the system are. On the other hand, probabilistically identifies the vulnerable components of the infrastructure that obviously should be under consideration of the operator. As a case study, a typical Danish low voltage grid is considered. The results obtained, using DIgSILENT PowerFactory, show that sometimes the hosting capability of these networks may be poor for the integration levels expected.
Stress-driven lymphatic dissemination: An unanticipated consequence of communication between the sympathetic nervous system and lymphatic vasculature

ABSTRACT Chronic stress drives cancer progression, but the routes of metastasis are unclear. We recently demonstrated that chronic stress activates a neural-inflammatory signaling axis to remodel lymphatic vasculature and increase lymph flow. This unanticipated crosstalk between stress and the lymphatic system provides pathways of tumor cell dissemination and accelerates metastasis.