Miracle-dz/UniFAR-FTUs huggingface dataset:
Expression of p63 in Reactive Hyperplasias and Malignant Lymphomas

p63 is a recently described p53 homologue. It is involved in survival and differentiation of reserve/stem cells in epithelia. To obtain new insights into the role of p63 in malignant lymphomas (MLs), immunohistochemical staining for p63 and p53 was performed in 126 cases of MLs. p63 was expressed in 38 cases of MLs (30.2%) including 32/61 cases (52.5%) of diffuse large B-cell lymphoma (DLBCL), 1/8 cases (12.5%) of precursor T-lymphoblastic lymphoma (T-LBL), 4/14 cases (28.6%) of follicular lymphoma, 1/6 cases (16.7%) of T/NK cell lymphoma. Among p63 positive cases, p63 was strongly expressed in 15/32 cases of DLBCL and 1/1 case of T-LBL. p63 was not expressed in mantle cell lymphomas, peripheral T-cell lymphomas, marginal zone B-cell lymphomas, plasma cell myelomas and Hodgkin's lymphomas. p63 was coexpressed with p53 in 18/38 p63 positive cases in which only 4 cases were strongly coexpressed. All p63+/p53+ cases were DLBCL. p63 overexpression (above 30%) cases showed significant poor survival (p=0.0228) in DLBCL. However, there was no statistically significant correlation between p63 expression and IPI score on Multivariate analysis. We could speculate that p63 could act indirectly as an oncogene by inhibiting p53 functions. Stage of differentiation of neoplastic lymphocytes appears to have a correlation with p63 expression in MLs.
DNA Methylation Characteristics of Primary Melanomas with Distinct Biological Behaviour

In melanoma, the presence of promoter related hypermethylation has previously been reported, however, no methylation-based distinction has been drawn among the diverse melanoma subtypes. Here, we investigated DNA methylation changes associated with melanoma progression and links between methylation patterns and other types of somatic alterations, including the most frequent mutations and DNA copy number changes. Our results revealed that the methylome, presenting in early stage samples and associated with the BRAFV600E mutation, gradually decreased in the medium and late stages of the disease. An inverse relationship among the other predefined groups and promoter methylation was also revealed except for histologic subtype, whereas the more aggressive, nodular subtype melanomas exhibited hypermethylation as well. The Breslow thickness, which is a continuous variable, allowed for the most precise insight into how promoter methylation decreases from stage to stage. Integrating our methylation results with a high-throughput copy number alteration dataset, local correlations were detected in the MYB and EYA4 genes. With regard to the effects of DNA hypermethylation on melanoma patients' survival, correcting for clinical cofounders, only the KIT gene was associated with a lower overall survival rate. In this study, we demonstrate the strong influence of promoter localized DNA methylation changes on melanoma initiation and show how hypermethylation decreases in melanomas associated with less favourable clinical outcomes. Furthermore, we establish the methylation pattern as part of an integrated apparatus of somatic DNA alterations.
Sporopollenin, The Least Known Yet Toughest Natural Biopolymer

Sporopollenin is highly cross-linked polymer composed of carbon, hydrogen and oxygen that is extraordinarily stable and has been found chemically intact in sedimentary rocks some 500 million year old. It is the outer shell (exine) of plant spores and pollen and when extracted it is in the form of an empty exine or microcapsule. The exines resemble the spores and pollen from which they are extracted, in size and morphology. Also, from any one plant such characteristics are incredible uniform. The exines can be used is microcapsules or simply as micron-sized particles due to the variety of functional groups on their surfaces. The loading of the exine microcapsules into their cavities is via multi-directional nano-diameter sized channels. The exines can be filled with a variety of polar and non-polar materials. Such as enzymes can be encapsulated within the shells and still remain active. In vivo studies in humans have shown that an encapsulated active substance can have a substantially increased bioavailability than if it is taken alone. The sporopollenin exine surface possesses phenolic, alkane, alkene, ketone, lactone and carboxylic acid groups. Therefore it can be derivatised in a number of ways, which has given rise to its having been used for, such as, solid supported for peptide synthesis, catalysis and ion-exchange chromatography. Also, the presence of the phenolic groups on sporopollenin endows it with antioxidant activity.
Attitudes towards healthy lifestyle promotion in mass media in the Polish adult population.

BACKGROUND Healthy lifestyle promotion in mass media is a very important way to diminish cardiovascular diseases morbidity and mortality. Effectiveness of healthy lifestyle promotion can, among others, depend on people's attitudes towards it. AIM To characterise the Pole's attitudes towards healthy lifestyle promotion in mass media and identify their socio-demographic predictors. METHODS A research project consisted of qualitative and quantitative studies. Qualitative research containing 30 individual in-depth interviews was carried out from June 2007 to April 2008. A survey on national Polish sample including 934 adults was conducted in November 2008. In the study there was used the scale to estimate the attitudes towards healthy lifestyle promotion in mass media containing four subscales: appraisal of the idea of healthy lifestyle promotion in mass media (regarding a need of healthy lifestyle promotion in mass media), appraisal of its practice (which means credibility as well as effectiveness manifested in the change of people's behaviour), propensity to receive messages and propensity to avoid messages promoting healthy lifestyle. RESULTS Above 71% of Poles is characterised by a positive attitude towards healthy lifestyle promotion in mass media. As much as 87% of people positively evaluate its idea; about 70% have high propensity to receive messages promoting healthy lifestyle and only 21% is characterised by high propensity to avoid them. On the contrary, only 29% of the respondents positively evaluate the practice of healthy lifestyle promotion in mass media. The results of multivariable linear regression analysis show that being a woman and having higher education are the predictors of relatively positive attitude towards healthy lifestyle promotion in mass media while living in the biggest cities and being executives or intellectuals are related to more negative attitude. CONCLUSIONS Results indicate the need to enhance credibility of messages promoting healthy lifestyle as well as create ones that would better reach men and low-educated people.
Software Visualization of Text Content in Ecosystem

Software ecosystem analysis is on focus due to open source communities. It need to be analyzed at the high level through visualization techniques for the better understanding of the interactive relationship. Analysis of ecosystem has been usually represented using developer’s data, project’s data, based on the dependencies that exist. Dependencies at high level are explored, while the low level fine grained information is unexplored. Thus an attempt has been done in this paper, to visualize the low level information related to open source ecosystem GRAPPA. This ecosystem’s source files are analyzed with the low level vocabularies such as non-keywords and represented as tag cloud. Tag cloud visualizes all the non-keywords such as class name, methods, and data in GRAPPA. This analysis exposes the project vocabularies with different weight based on the frequency count. Keywords— software ecosystem, text visualization, tag cloud, tag operation.
Can Electronic Medical Record Systems Transform Health Care? Potential Health Benefits, Savings, and Cost Using Latest Advancements in ICT for Better interactive Healthcare Learning

— To broadly examine the potential health and financial benefits of health information technology (HIT), this paper compares health care with the use of ICT in other industries. It estimates potential savings and costs of widespread adoption of electronic medical record (EMR) systems, models important health and safety benefits, and concludes that effective EMR implementation and networking could eventually save more than billions annually-by improving health care efficiency and safety-and that HIT-enabled prevention and management of chronic disease could eventually double those savings while increasing health and other social benefits. However, this is unlikely to be realized without related changes to the health care system. Finally, we discuss the importance of collaboration between projects in the development of electronic medical record systems rather than reinventing systems in isolation, and the use of open standards and open source technology.
KRAS-dependent suppression of MYC enhances the sensitivity of cancer cells to cytotoxic agents

KRAS is the most commonly mutated oncogene, frequently associated with some of the deadliest forms of cancer. However, the need for potent and specific KRAS inhibitors remains unmet. Here, we evaluated the effects of selected cytotoxic agents on oncogenic KRAS signaling and drug response. The data provided new insights into the functional interaction between the KRAS and MYC pathways and revealed key differences between WT and mutant KRAS expressing cells. Systematic investigation of non-small cell lung cancer cell lines revealed that KRAS mutation can paradoxically increase the sensitivity of cells to cytotoxic agents. We identify MYC as a key regulator of the cellular stress responses and tumor cell viability as MYC expression was suppressed in drug-sensitive but not resistant cells. Furthermore, this suppression was driven by hyperactive KRAS/MAPK signaling. Our findings support a direct link between MYC and cancer cell viability, and raise the possibility that inactivation of MYC may be an effective therapeutic strategy for KRAS mutant tumors across various cancer types.
Draft Genome Sequence of Pediococcus lolii NGRI 0510QT Isolated from Ryegrass Silage

ABSTRACT Pediococcus lolii NGRI 0510QT was isolated from ryegrass silage produced on Ishigaki Island, Okinawa Prefecture, Japan. Here we present a draft genome sequence for this strain, consisting of 103 contigs for a total of 2,047,078 bp, 2,154 predicted coding sequences, and a G+C content of 42.1%.
The relationship between isokinetic knee strength and jumping in young male volleyball players

Volleyball is a dynamic physical game that does not have a definite match duration but is based on high tempo, quickness, strength, flexibility, endurance and jumping. The aim of this study is to research the relationship between isokinetic knee strength and jumping height in young male volleyball players. 8 male volleyball players aged between 18-22 participated in the research voluntarily. In the study, the physical characteristics of the subjects (body height, body weight, body mass index) were determined, vertical jump heights were measured and at low (60 0 /sec) and high (300 0 /sec) speeds, the right and left knee flexion/extension concentric isokinetic strength test was applied. Data was analyzed with paired sample t-test and Spearman correlation coefficient test was used to determine the relationship between vertical jump and isokinetic strength (p<0.05). The right and left knees peak torque of the athletes were compared at low and high angular speeds and no significant difference was found. A significant positive correlation was detected between the jumping height and the right knee peak torque at low angular speed (r =.817, p<0.05). This result can be explained by the fact that quadriceps femoris, which is the biggest muscle of the lower extremity, is in the foreground during the jumps that volleyball players perform frequently. It may be advisable to give importance to leg strength training to increase the jump height.
Software for Computing the Spheroidal Wave Functions Using Arbitrary Precision Arithmetic

The spheroidal wave functions, which are the solutions to the Helmholtz equation in spheroidal coordinates, are notoriously difficult to compute. Because of this, practically no programming language comes equipped with the means to compute them. This makes problems that require their use hard to tackle. We have developed computational software for calculating these special functions. Our software is called spheroidal and includes several novel features, such as: using arbitrary precision arithmetic; adaptively choosing the number of expansion coefficients to compute and use; and using the Wronskian to choose from several different methods for computing the spheroidal radial functions to improve their accuracy. There are two types of spheroidal wave functions: the prolate kind when prolate spheroidal coordinates are used; and the oblate kind when oblate spheroidal coordinate are used. In this paper, we describe both, methods for computing them, and our software. We have made our software freely available on our webpage.
A National Agenda for Public Health Systems Research on Emergency Preparedness

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HAWK-I imaging of the X-ray luminous galaxy cluster XMMU J2235.3-2557 : The red sequence at z =1.39

We use HAWK-I, the recently-commissioned near-IR imager on Yepun (VLT-UT4), to obtain wide-field, high-resolution images of the X-ray luminous galaxy cluster XMMU J2235.3-2557 in the J and K s bands, and we use these images to build a colour-magnitude diagram of cluster galaxies. Galaxies in the core of the cluster form a tight red sequence with a mean $J-K\mathrm{s}$ colour of 1.9 (Vega system). The intrinsic scatter in the colour of galaxies that lie on the red sequence is similar to that measured for galaxies on the red sequence of the Coma cluster. The slope and location of the red sequence can be modelled by passively evolving the red sequence of the Coma cluster backwards in time. Using simple stellar population (SSP) models, we find that galaxies in the core of XMMU J2235.3-2557 are, even at $z=1.39$, already 3 Gyr old, corresponding to a formation redshift of $z_{\rm f} \sim 4$. Outside the core, the intrinsic scatter and the fraction of galaxies actively forming stars increase substantially. Using SSP models, we find that most of these galaxies will join the red sequence within 1.5 Gyr. The contrast between galaxies in the cluster core and galaxies in the cluster outskirts indicates that the red sequence of XMMU J2235.3-2557 is being built from the dense cluster core outwards.
A Bayesian Based Method for Agile Software Development Release Planning and Project Health Monitoring

Agile software development (ASD) techniques are iteration based powerful methodologies to deliver high quality software. To ensure on time high quality software, the impact of factors affecting the development cycle should be evaluated constantly. Quick and precise factor evaluation results in better risk assessment, on time delivery and optimal use of resources. Such an assessment is easy to carry out for a small number of factors. However, with the increase of factors, it becomes extremely difficult to assess in short time periods. We have designed and developed a project health measurement model to evaluate the factors affecting software development of the project. We used Bayesian networks (BNs) as an approach that gives such an estimation. We present a quantitative model for project health evaluation that helps decision makers make the right decision early to amend any discrepancy that may hinder on time and high quality software delivery.
Abstractions for Context-aware Object References

ions for Context-aware Object References Tom Van Cutsem∗ Jessie Dedecker∗ Stijn Mostinckx† Wolfgang De Meuter Programming Technology Lab Vrije Universiteit Brussel Pleinlaan 2 1050 Brussels Belgium {tvcutsem,jededeck,smostinc,wdmeuter}@vub.ac. be
Late Miocene–Pleistocene tectono-sedimentary evolution and subsidence history of the central Betic Cordillera (Spain): a case study in the Guadix intramontane basin

The Guadix Basin became established as an intramontane basin in the central sector of the Betic Cordillera at the beginning of Late Miocene time. Its geodynamic evolution starts with a unit of Tortonian marine sediments and is completed by a unit of Late Turolian–Pleistocene continental sediments. In the two units, six depositional sequences have been differentiated whose boundaries, in most cases, coincide with tectonic events. Geohistorical diagrams show the results of quantitative analyses of subsidence in the northern sector of the basin and permit correlation of the main events with significant changes in the history of subsidence and uplift. A period of strong subsidence occurred at the beginning of Tortonian time causing the formation of a marine basin 800 m deep. The mid- and end-Tortonian tectonic events involved periods of uplift leading to shallowing in the basin. After continentalization at the end of the Tortonian, the basin was uplifted continuously from Late Turolian to Late Pleistocene times, finally accumulating sediments at a height of 1000 m.
The Impacts of Climate Change Mitigation Strategies on Animal Welfare

Simple Summary Climate change is probably the most important environmental issue of our time. Raising animals for food contributes to the production of greenhouse gases implicated in the global warming that is causing climate change. To combat this ecological disaster, a number of mitigation strategies involving changes to agricultural practices have been proposed. However, some of these changes will impact the welfare of farmed animals. This paper reviews selected climate change mitigation strategies and explains how different approaches could have negative or positive effects. Abstract The objective of this review is to point out that the global dialog on reducing greenhouse gas emissions in animal agriculture has, thus far, not adequately considered animal welfare in proposed climate change mitigation strategies. Many suggested approaches for reducing emissions, most of which could generally be described as calls for the intensification of production, can have substantial effects on the animals. Given the growing world-wide awareness and concern for animal welfare, many of these approaches are not socially sustainable. This review identifies the main emission abatement strategies in the climate change literature that would negatively affect animal welfare and details the associated problems. Alternative strategies are also identified as possible solutions for animal welfare and climate change, and it is suggested that more attention be focused on these types of options when allocating resources, researching mitigation strategies, and making policy decisions on reducing emissions from animal agriculture.
Sample Selection in Models of Academic Performance

This article shows how admission and enrollment processes affect the interpretation of simple validation studies of academic performance. In a competitive market for students, optimal behavior of admissions committees and applicants drives the simple correlation between test scores and performance toward zero, regardless of the relationship in the population of prospective students. Data from our university's MBA program support the prediction that applicants exhibit a higher correlation between test scores and undergraduate GPAs than do current students. This suggests that standard validation studies will understate the importance of GMAT scores in predicting performance of potential MBA students. (JEL C24, I121, C52) Copyright 2004, Oxford University Press.
Optimal leverage association rules with numerical interval conditions

In this paper we propose a framework for defining and discovering optimal association rules involving a numerical attribute A in the consequent. The consequent has the form of interval conditions A, A≥ x or A ∈ I where I is an interval or a set of intervals of the form [x_l,x_u. The optimality is with respect to leverage, one well known association rule interest measure. The generated rules are called Maximal Leverage Rules MLR and are generated from Distribution Rules. The principle for finding the MLR is related to the Kolmogorov-Smirnov goodness of fit statistical test. We propose different methods for MLR generation, taking into account leverage optimallity and readability. We theoretically demonstrate the optimality of the main exact methods, and measure the leverage loss of approximate methods. We show empirically that the discovery process is scalable.
On continuous variable quantum algorithms for oracle identification problems

We establish a framework for oracle identification problems in the continuous variable setting, where the stated problem necessarily is the same as in the discrete variable case, and continuous variables are manifested through a continuous representation in an infinite-dimensional Hilbert space. We apply this formalism to the Deutsch-Jozsa problem and show that, due to an uncertainty relation between the continuous representation and its Fourier-transform dual representation, the corresponding Deutsch-Jozsa algorithm is probabilistic hence forbids an exponential speed-up, contrary to a previous claim in the literature.
Development and Acceptability of a Co-Produced Online Intervention to Prevent Alcohol Misuse in Adolescents: A Think Aloud Study

Background The prototype willingness model (PWM) may offer an appropriate basis for explaining and preventing adolescent alcohol misuse. An intervention was developed using a co-production approach, and consisted of an online quiz featuring 10 questions linked to the PWM. Objective This study sought to determine the acceptability and relevance of the intervention content to young people, to incorporate their feedback into a final version. Methods A qualitative think aloud study with follow-up semistructured interviews was undertaken with 16 young people aged 11-15 (50%). Transcripts were analyzed using thematic analysis. Results The following 3 main themes relating the acceptability of the intervention were identified: “challenging expectations of alcohol education”; “motivations for drinking or not drinking,” and “the inevitability of drinking. ” Participants found the intervention appealing because it was counter to their expectations. The content appeared to reflect their experiences of social pressure and drinking encounters. There was evidence that a focus on drinker/nondrinker prototypes was too narrow and that because adolescents perceived drinking as inevitable, it would be challenging to enact any plans to resist pressure to drink. Conclusions An online intervention based on the PWM has the potential to engage and interest adolescents. A wide range of alcohol prototypes should be targeted and a focus on short-term harms should ensure that the intervention is credible to young people.