Miracle-dz/UniFAR-FTUs huggingface dataset:
Advances in Brief Fez 1 / Lzts 1 Alterations in Gastric Carcinoma 1

Purpose: Loss of heterozygosity (LOH) involving the short arm of chromosome 8 (8p) is a common feature of the malignant progression of human tumors, including gastric cancer. We have cloned and mapped a candidate tumor suppressor gene,FEZ1/LZTS1, to 8p22. Here we have analyzed whether FEZ1/LZTS1 alterations play a role in the development and progression of gastric carcinoma. Experimental Design:We examined Fez1/Lzts1 expression in 8 gastric carcinoma cell lines by Western blot, and in 88 primary gastric carcinomas by immunohistochemistry. Twenty-six of these 88 primary gastric carcinomas were also microdissected and tested for LOH at theFEZ1/LZTS1 locus and for mutation of the FEZ1/LZTS1gene. Furthermore, we studied the FEZ1/LZTS1 gene regulation and transcriptional control and the methylation status of the 5* region of the gene in all 8 gastric carcinoma cell lines. Results:Fez1/Lzts1 protein was barely detectable in all of the gastric cancer cell lines tested and was absent or significantly reduced in 39 of the 88 (44.3%) gastric carcinomas analyzed by immunohistochemistry, with a significant correlation (P < 0.001) to diffuse histotype. DNA allelotyping analysis showed allelic loss in 3 of 17 (18%) and microsatellite instability in 4 of 17 (23.5%) cases informative for D8S261at the FEZ1/LZTS1 locus. When we compared the presence of LOH with Fez1/Lzts1 expression, we found loss of protein expression in all three of the tumors with allelic imbalance at D8S261. A missense mutation was detected in one case that did not express Fez1/Lzts1. Hypermethylation of the CpG island flanking the Fez1/Lzts1 promoter was evident in six of the eight cell lines examined as well as in the normal control. Conclusions: Our findings support FEZ1/LZTS1 as a candidate tumor suppressor gene at 8p in a subtype of gastric cancer and suggest that its inactivation is attributable to several factors including genomic deletion and methylation.
Efficient Detection of XML Integrity Constraints

Knowledge of integrity constraints covered in XML data is an important aspect of efficient data processing. However, although integrity constraints are defined for the given data, it is a common phenomenon that data violate the predefined set of constraints. Therefore detection of these inconsistencies and consecutive repair has emerged. This work extends and refines recent approaches to repairing XML documents violating defined set of integrity constraints, specifically so-called functional dependencies. The work proposes the repair algorithm incorporating the weight model and also involve a user into the process of detection and subsequent application of appropriate repair of inconsistent XML documents. Experimental results are part of the work.
Quasars and Ultraluminous Infrared Galaxies: At the Limit?

We have detected the host galaxies of 16 nearby, radio-quiet quasars using images obtained with the Near-Infrared Camera and MultiObject Spectrometer. We confirm that these luminous quasars tend to live in luminous, early-type host galaxies, and we use the host-galaxy magnitudes to refine the luminosity/host-mass limit inferred from ground-based studies. If quasars obey the relation Mblackhole/Mspheroid ~ 0.006 found for massive dark objects in nonactive galaxies, then our analysis implies that they radiate at up to ~20% of the Eddington rate. An analogous analysis for ultraluminous infrared galaxies shows them to accrete at up to similar Eddington fractions, consistent with the hypothesis that some of them are powered by embedded quasars.
Exciton-dominant electroluminescence from a diode of monolayer MoS 2

In two-dimensional monolayer MoS2, excitons dominate the absorption and emission properties. However, the low electroluminescent efficiency and signal-to-noise ratio limit our understanding of the excitonic behavior of electroluminescence. Here, we study the microscopic origin of the electroluminescence from a diode of monolayer MoS2 fabricated on a heavily p-type doped silicon substrate. Direct and bound-exciton related recombination processes are identified from the electroluminescence. At a high electron-hole pair injection rate, Auger recombination of the exciton-exciton annihilation of the bound exciton emission is observed at room temperature. Moreover, the efficient electrical injection demonstrated here allows for the observation of a higher energy exciton peak of 2.255 eV in the monolayer MoS2 diode, attributed to the excited exciton state of a direct-exciton transition. VC 2014 AIP Publishing LLC. [http://dx.doi. org/10.1063/1.4875959]
Novel Immunotherapies and Immunoregulation in a Chronic Inflammatory Disease of the Central Nervous System

Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system (CNS) which is thought to arise from a breakdown of immunological tolerance in CD4 cells. The aim of this thesis is to improve our understanding of regulation mechanisms of T cell-dependent chronic inflammation in the CNS and explore ways to overcome the onset and progression of the disease, which can be an important step forward in the treatment of MS. We have utilized the Experimental Autoimmune Encephalomyelitis (EAE), as a mouse model for MS. Chronic EAE was induced by immunization with the myelin oligodendrocyte glycoprotein (MOG) 35-55 peptide. MOG-reactive inflammatory CD4+ T cells infiltrate the CNS and, in concert with other mononuclear cells, cause inflammation and progressive paralysis. The focus of the first study was to evaluate the immunoregulatory role of CD1d-restricted T cells by using CD1d deficient mice. Our results suggest a regulatory role of CD1d-restricted T cells in EAE. This regulation functions through limiting the autoreactive T cell cytokine responses and enhancing TGF-beta1 production in the CNS. In another study, we investigated the therapeutic potential of monoclonal antibody (H57-597 mAb) against the T cell receptor (TCR) alpha/beta. We demonstrated that short term administration of anti-TCR alpha/beta can protect mice from EAE and is tolerogenic in established chronic EAE. We concluded that treatment with anti-TCR alpha/beta restores self-tolerance through a transient deletion of T cells including the autoreactive populations and a selective expansion of regulatory NKT cells. Finally, we evaluated the immunosuppressive potential of various probiotic bacteria strains in chronic EAE. We showed that oral administration of Lactobacillus paracasei DSM 13434, Lactobacillus plantarum DSM 15312 or Lactobacillus plantarum DSM 15313 suppressed EAE development by down-regulating autoreactive Th1 cells. The protective effect of the probiotic treatment was shown to be associated with an expansion of regulatory T cells in mesenteric lymph nodes and spleen followed by an increased production of IL-4, IL-10 and TGF-beta. We further demonstrated the powerful therapeutic potential of these bacteria in diseased animals when treating with a combination of these probiotic strains. (Less)
Determination of in vitro susceptibility of Mycobacterium tuberculosis to cephalosporins by radiometric and conventional methods

Among eight cephalosporins and cephamycins tested in preliminary in vitro screening against Mycobacterium tuberculosis, the most promising for further study was found to be ceforanide, followed by ceftizoxime, cephapirin, and cefotaxime. Moxalactam, cefoxitin, cefamandole, and cephalothin were found to be not active enough against M. tuberculosis to be considered for further in vitro studies. The antibacterial activity of various ceforanide concentrations was investigated by three methods: (i) the dynamics of radiometric readings (growth index) in 7H12 broth; (ii) the number of CFU in the same medium; and (iii) the proportion method on 7H11 agar plates. There was a good correlation among the results obtained with these methods. The MIC for most strains ranged from 6.0 to 25.0 micrograms/ml. The BACTEC radiometric method is a reliable, rapid, and convenient method for preliminary screening and determination of the level of antibacterial activity of drugs not commonly used against M. tuberculosis.
Mechanisms of Tolerance Induction by Dendritic Cells In Vivo

Dendritic cells (DCs) are a heterogeneous population playing a pivotal role in immune responses and tolerance. DCs promote immune tolerance by participating in the negative selection of autoreactive T cells in the thymus. Furthermore, to eliminate autoreactive T cells that have escaped thymic deletion, DCs also induce immune tolerance in the periphery through various mechanisms. Breakdown of these functions leads to autoimmune diseases. Moreover, DCs play a critical role in maintenance of homeostasis in body organs, especially the skin and intestine. In this review, we focus on recent developments in our understanding of the mechanisms of tolerance induction by DCs in the body.
FATIGUE LIMIT AND FATIGUE LIFE PREDICTION IN HIGH STRENGTH COLD DRAWN EUTECTOID STEEL WIRES

La limite de fatigue et la duree de vie de fatigue sont fortement dependantes de l'etat de surface et de la vitesse de propagation des microfissures. Developpement d'un modele base sur la mecanique de rupture lineaire elastique pour la prevision de la duree de vie de la limite de fatigue. Ce modele prend en compte les deux parametres: etat de surface et vitesse de propagation. Presentation des facteurs pouvant etre modifies pour augmenter le comportement en fatigue des fils d'acier eutectoide
Automatic Extraction of English-Korean Translations for Constituents of Technical Terms

Technical terms are linguistic realization of a domain concept and their constituents are a component used for representing the concept. Many technical terms are usually multi-word terms and their meaning can be inferred from their constituents. Because a term constituent is usually a morphological unit rather than a conceptual unit in Korean technical terms, we need to first identify conceptual units and then to resolve the proper meaning of the conceptual units in order to properly translate technical terms. For natural language applications to properly handle technical terms, it is necessary to give information about conceptual units and their meaning including homonym, synonym and domain dependency. In this paper, we propose a term constituent alignment algorithm, which extracts such information from bilingual technical term pairs. Our algorithm regards English term constituents as a conceptual unit and then finds its Korean counterpart. Our method shows about 6.1% AER.
Business driven engineering for powertrain industry

The Market for the automation industry is rapidly changing and there is tougher competition and greater demand for higher quality products with lower cost and faster delivery to market. However in today's economy, the extra cost for higher quality has to be supported by lowering the production costs and optimizing the resources. In this regard, the powertrain sector of the automobile industry has been the focus of research collaboration between Loughborough University and Ford Motor Company to provide a new approach to the design and reuse of automation systems. In this article work-in-progress is reported which outlines the development of a set of engineering services and its associated engineering application tools. This is aimed to enable industrial end users to enhance the reconfigurability and agility of their development environment via the use of virtual engineering and component-based approaches.
Double cladding photonic crystal fiber based on dual lattice structure: High birefringence and negative flat dispersion

We proposed double cladding photonic crystal fibers based on dual lattice structure which has high and flattened birefringence. Using double cladding structure of square lattice, high flat birefringence and negative flat dispersion can be achieved at the same time over wide wavelength region including S, C and L bands.
Evaluation of MANET Performance in Presence of Obstacles

The mobility models are used to represent the unpredictable movement pattern of the nodes in Mobile Adhoc Network (MANET) and give us an idea regarding their location, velocity and acceleration change over time. These models are used for simulation purpose in standard software tools such as QualNet, ns-2 etc. This paper evaluates the performance of routing protocols for mobility models such as Random Way Point (RWP), Random Walk (RW) and Random Direction (RD) in presence of obstacles like mountain which restricts node movement as well obstruct transmission path between nodes based on a parameter termed as Probability of Reachability (POR). The POR is defined as the fraction of reachable routes to all possible routes between all pairs of sources and destinations. For this purpose a simulator is designed in MATLAB. We observe a marked difference in value of POR in presence of obstacles as well as variation in number of obstacles.
Characterization and modeling of near-fault pulse-like strong ground motion via damage-based critical excitation method

Near-fault ground motion with directivity or fling effects is significantly influenced by the rupture mechanism and substantially different from ordinary records. This class of ground motion has large amplitude and long period, exhibits unusual response spectra shapes, possesses high PGV/PGA and PGD/PGA ratios and is best characterized in the velocity and the displacement time-histories. Such ground motion is also characterized by its energy being contained in a single or very few pulses, thus capable of causing severe damage to the structures. This paper investigates the characteristics of near-fault pulse-like ground motions and their implications on the structural responses using new proposed measures, such as, the effective frequency range, the energy rate (in time and frequency domains) and the damage indices. The paper develops also simple mathematical expressions for modeling this class of ground motion and the associated structural responses, thus eliminating numerical integration of the equations of motion. An optimization technique is also developed by using energy concepts and damage indices for modeling this class of ground motion for inelastic structures at sites having limited earthquake data.
Relationships between Prostate-Specific Antigen, Prostate Volume, and Components of Metabolic Syndrome in Healthy Korean Men

Purpose Metabolic syndrome (MS) plays a potential role in the etiology of benign prostatic hyperplasia (BPH). Recent studies have reported on an association between MS and BPH. However, there has been no consensus on recent results. This study was conducted to evaluate the associations among prostate-specific antigen (PSA), prostate volume (PV), and metabolic components in men who visited our health promotion center. Materials and Methods During the period from January 2005 to December 2010, 521 consecutive men (age range, 40 to 70 years) who underwent transrectal ultrasonography were enrolled in this retrospective study. The health screening program includes blood pressure, body measurements (height, weight, waist circumference, body mass index), biochemical analysis (serum glucose, total cholesterol, triglycerides, high-density and low-density lipoprotein cholesterol, fasting plasma glucose, tumor markers), stool and urine analysis, and a detailed clinical examination. Results The serum PSA level and PV were significantly higher in patients with MS than in patients without MS, retrospectively (p<0.001, p<0.001). Patients with more than one metabolic component were significantly more likely to have a larger PV and higher serum PSA level. The serum PSA level and PV were increased in a similar manner with the increasing sum of MS components (p<0.0001, p<0.0001). Conclusions The MS components were associated with larger PV and higher serum PSA level. Therefore, each MS component could be an important factor in BPH development and management.
Using no-show modeling to improve clinic performance

‘No-shows’ or missed appointments result in under-utilized clinic capacity. We develop a logistic regression model using electronic medical records to estimate patients’ no-show probabilities and illustrate the use of the estimates in creating clinic schedules that maximize clinic capacity utilization while maintaining small patient waiting times and clinic overtime costs. This study used information on scheduled outpatient appointments collected over a three-year period at a Veterans Affairs medical center. The call-in process for 400 clinic days was simulated and for each day two schedules were created: the traditional method that assigned one patient per appointment slot, and the proposed method that scheduled patients according to their no-show probability to balance patient waiting, overtime and revenue. Combining patient no-show models with advanced scheduling methods would allow more patients to be seen a day while improving clinic efficiency. Clinics should consider the benefits of implementing scheduling software that includes these methods relative to the cost of no-shows.
Polar martingales of maximal spread

This paper investigates polar codes for q-ary input channels using other kernels than [ 1 0 1 1 ] to construct the generator matrix. The kernel is optimized by maximizing the spread of the polar martingale and it is shown that in certain cases, the resulting construction has a significantly improved error probability (even at small block length like n = 1024).
Clinical Guidelines for the Management of Adrenal Incidentaloma

An adrenal incidentaloma is an adrenal mass found in an imaging study performed for other reasons unrelated to adrenal disease and often accompanied by obesity, diabetes, or hypertension. The prevalence and incidence of adrenal incidentaloma increase with age and are also expected to rise due to the rapid development of imaging technology and frequent imaging studies. The Korean Endocrine Society is promoting an appropriate practice guideline to meet the rising incidence of adrenal incidentaloma, in cooperation with the Korean Adrenal Gland and Endocrine Hypertension Study Group. In this paper, we discuss important core issues in managing the patients with adrenal incidentaloma. After evaluating core proposition, we propose the most critical 20 recommendations from the initially organized 47 recommendations by Delphi technique.
An Overview of the Predictor Standard Tools for Patient Weaning from Mechanical Ventilation

Most patients staying in the intensive care unit (ICU) require respiratory support through a ventilator. Since prolonged mechanical ventilation and weaning from the ventilator without criteria or at the inappropriate time can result in many complications, it is required that patients be weaned off the ventilator as soon as possible. This study was conducted to investigate a few standard tools that predict successful and timely weaning of patients from the ventilator. In the literature, SOFA and APACHE II scores, along with various tools, including Burn, Morganroth, and Corgian, have been used in weaning patients from the ventilator. In most of these studies, the increase or decrease in the APACHE II score was correlated with the patient’s weaning time, and this score could be used as a criterion for weaning. Several authors have expressed their belief that the SOFA score in the ICU is a good indicator of the prognosis of patient’s weaning from the ventilator, length of stay, mortality, and rate of recovery. Several studies have compared SOFA and APACHE II scores and have shown that there is a positive correlation between the SOFA and APACHE II scores and that both mortality and dependence on the ventilator are related to these two scores. Another tool is Burn’s weaning program. A higher Burn score indicates successful weaning off of the ventilator, successful extubation, lower length of mechanical ventilation, and shorter stay in the hospital. However, the capabilities of the Morganroth scale and the Gluck and Corgian scoring systems were evaluated only for successful weaning off of the ventilator, and a decrease in the Morganroth and Gluck scores indicated successful weaning.
Expression of Stem Cell Markers in the Human Fetal Kidney

In the human fetal kidney (HFK) self-renewing stem cells residing in the metanephric mesenchyme (MM)/blastema are induced to form all cell types of the nephron till 34th week of gestation. Definition of useful markers is crucial for the identification of HFK stem cells. Because wilms' tumor, a pediatric renal cancer, initiates from retention of renal stem cells, we hypothesized that surface antigens previously up-regulated in microarrays of both HFK and blastema-enriched stem-like wilms' tumor xenografts (NCAM, ACVRIIB, DLK1/PREF, GPR39, FZD7, FZD2, NTRK2) are likely to be relevant markers. Comprehensive profiling of these putative and of additional stem cell markers (CD34, CD133, c-Kit, CD90, CD105, CD24) in mid-gestation HFK was performed using immunostaining and FACS in conjunction with EpCAM, an epithelial surface marker that is absent from the MM and increases along nephron differentiation and hence can be separated into negative, dim or bright fractions. No marker was specifically localized to the MM. Nevertheless, FZD7 and NTRK2 were preferentially localized to the MM and emerging tubules (<10% of HFK cells) and were mostly present within the EpCAMneg and EpCAMdim fractions, indicating putative stem/progenitor markers. In contrast, single markers such as CD24 and CD133 as well as double-positive CD24+CD133+ cells comprise >50% of HFK cells and predominantly co-express EpCAMbright, indicating they are mostly markers of differentiation. Furthermore, localization of NCAM exclusively in the MM and in its nephron progenitor derivatives but also in stroma and the expression pattern of significantly elevated renal stem/progenitor genes Six2, Wt1, Cited1, and Sall1 in NCAM+EpCAM- and to a lesser extent in NCAM+EpCAM+ fractions confirmed regional identity of cells and assisted us in pinpointing the presence of subpopulations that are putative MM-derived progenitor cells (NCAM+EpCAM+FZD7+), MM stem cells (NCAM+EpCAM-FZD7+) or both (NCAM+FZD7+). These results and concepts provide a framework for developing cell selection strategies for human renal cell-based therapies.
Mechanical Mesh Segmentation and Global 3D Shape Extraction

This paper presents a method for segmenting noisy 2-manifold meshes based on a decomposition into local shape primitives maximizing global coherence. This technique works by partitioning the input mesh into regions which can be approximated by a simple geometrical primitive such as a plane, a sphere or a cylinder. The proposed approach is entirely error-driven, convergence-proven, and does not need to specify a number of segments. The partitioning is guided by robust shape extractions based on RANSAC sampling and by a global graphical model which regularizes the segmented regions. The final decomposition is based on the minimum of the energy associated with this graphical model. Obtained segmentations on noisy mechanical meshes outperform other approaches in terms of region contour correctness and consistency with mechanical object decomposition. Applications of this work are reverse engineering, mesh structure analysis, mesh feature enhancement, noise removal, mesh compression, piecewise approximation of mesh geometry, and remeshing.