Miracle-dz/UniFAR-FTUs huggingface dataset:
Predictive Maintenance Planning With Fuzzy Neural Networks and Multi Criteria Decision Making Method in Parts Manufacturer

with the advent of predictive maintenance in 1980, dramatic changes occurred in equipment planning perspective. Given that predictive maintenance, based on predictive failure on equipment in use, it can be previewed more truly predict of the occurrence of failures in the future. As if maintenance costs can be significantly reduced; this approach requires the use of multiple tools and techniques. Such as techniques are utilizing in artificial intelligence, neural networks and fuzzy set theory. Parts manufacturer of the vehicles (original manufacturer service providers) in Iran have the significant maintenance costs among the industries. Therefore, the use of predictive maintenance is economically justified. Molding industry is preferred because production process and the use of such mold due to heavy use, depreciation is incurred numerously. This makes development expenses for parts manufacturer. In this study, predictive failure model based on combined fuzzy neural network and multi criteria decision making was performed. The results show that the proposed model reduce inspection costs 42% compared to the current situation.
Modeling and Simulating the Brain as a System

We discuss some of the key research roles that played by simulation and modeling, performance engineering, distributed computing, architectures, visualization and other key technologies of interest to the PADS community. In particular, the discussion presents a concept for the development of isomorphic, hierarchical architectures and principles of operation of the brain at multiple levels, using interactive visualization and distributed simulation techniques.
The Nonconventional MHC Class II Molecule DM Governs Diabetes Susceptibility in NOD Mice

The spontaneous destruction of insulin producing pancreatic beta cells in non-obese diabetic (NOD) mice provides a valuable model of type 1 diabetes. As in humans, disease susceptibility is controlled by the classical MHC class II genes that guide CD4+ T cell responses to self and foreign antigens. It has long been suspected that the dedicated class II chaperone designated HLA-DM in humans or H-2M in mice also makes an important contribution, but due to tight linkage within the MHC, a possible role played by DM peptide editing has not been previously tested by conventional genetic approaches. Here we exploited newly established germ-line competent NOD ES cells to engineer a loss of function allele. DM deficient NOD mice display defective class II peptide occupancy and surface expression, and are completely protected against type 1 diabetes. Interestingly the mutation results in increased proportional representation of CD4+Foxp3+ regulatory T cells and the absence of pathogenic CD4+ T effectors. Overall, this striking phenotype establishes that DM-mediated peptide selection plays an essential role in the development of autoimmune diabetes in NOD mice.
Induction of Apoptosis in Human Promyelocytic Leukemia HL60 Cells by Panaxynol and Panaxydol

Panaxynol and panaxydol are naturally occurring polyacetylenes, isolated from the lipophilic fractions of Panax notoginseng, that exert anti-proliferative effects against malignant cells. However, to the best of our knowledge, no study concerning the inhibitory effects of the two polyacetylenes on cell growth of human promyelocytic leukemia cells has been reported. In this paper, we examined the antiproliferation and proapoptotic effects of panaxynol and panaxydol on HL60 cells and investigated their mechanism of action. Cell growth inhibition of panaxynol and panaxydol were determined by trypan blue dye exclusion assays. Apoptosis of cells was revealed by morphological observation, analysis for nuclear DNA distribution and by annexin V-FITC/ PI staining using flow cytometry. It was found that panaxynol and panaxydol markedly inhibited proliferation of HL60 cells in a time- and dose-dependent manner via an apoptotic pathway. In concern with these ﬁndings, Western blot analysis showed proteolytic activation of PKCδ, caspase-3 activation and cleavage of poly (ADP [adenosine diphosphate]-ribose) polymerase in HL60 cells treated by panaxynol and panaxydol. In conclusion, panaxynol and panaxydol have profound effects on growth and apoptosis of HL60 cells, suggesting those substances are worthy of further exploration as potential anti-cancer agents.
Some Reflections on the Legacies of Michael White: An Australian Perspective

This article, which appears in a special 30-year anniversary edition of the Australian and New Zealand Journal of Family Therapy, reflects on the legacies of the work of Michael White. It begins by looking back on Michael's time as editor of the Australian Journal of Family Therapy. Of the many themes that were discussed in the Editorials and Letters to the Editor section of this journal in the early 1980s, this article focuses on three in particular to explore the legacies of the work of Michael White. The author describes how Michael has bequeathed not only a profound body of work, but also a distinctive spirit of originating, and ways of working that consider the effects of social issues and that examine the politics of experience. It is the author's hope that this approach to considering Michael White's legacies honours his work and also honours the contributions of the Australian and New Zealand Journal of Family Therapy in its 30th year.
An elaborated administration of the wechsler memory scale-revised

Abstract The Wechsler Memory Scale-Revised (Wechsler, 1987) was elaborated by adding 20 recognition items for Logical Memory (LM) and by adding recognition, matching, and copy trials for Visual Reproductions (VR). Reliability was very good for VR copy (α = .77, interrater agreement, 100% within 1 point). Reliability was modest for LM recognition (α = .42) and for VR recognition (α = .58), but reasonable given the small number of items on each measure. The reliability coefficient was very weak for VR matching (a = .10), limited considerably by the ease of the task for this healthy sample and by the small number of items. After statistically correcting for imperfect reliability, validity coefficients (correlations with similar tests that are well standardized) were good for all of the new trials (r = .60 to r = 1.00). Age- and education-appropriate reference data are provided using 81 healthy adults. Further validation using theoretically and clinically meaningful patient groups would be very valuable. In t.
Cooperative Orientation, Trust, and Reciprocity

Two related processes are hypothesized to mediate the effect of cooperative orientation on cooperative behavior in a conflict situation: development of trust and development of positive reciprocity. Hypotheses derived from assumptions about these processes are tested in two experiments using a two-person game situation with one-way feedback. Independent variables are: orientation (to group vs. to individual outcomes): level of cooperative feedback (high vs. low); gender (male vs. female dyads; and, in one experiment, risk (Prisoner's Dilemma vs. No Risk goal structure); and, in the other experiment, order (behavior occurring early in the experiment vs. behavior occurring later). Dependent variables are choices and guesses about other's next choice. In one experiment, all subjects saw all conditions while in the other, only level of feedback changed for each subject. Results show a significant main effect of orientation, feedback, and risk on choices and correlation between guesses and choices in some but not all conditions. In one experiment, hypotheses about interaction effects derived from the trust model are supported while in the other experiment no interaction effects appear.
Psychological well-being and pilgrimage: Religiosity, happiness and life satisfaction of ArdhâKumbh Mela pilgrims (Kalpvasis) at Prayag, India

Pilgrimage is an important aspect of our life and has both religious as well as spiritual significance. The present study examined the relationship of religiosity, happiness and satisfaction with life in the case of pilgrims in a very special cultural context of the Ardh-Kumbh Mela (held in Prayag, Allahabad, India) during the months of January and February, 2007). The study specifically examined these relationships in a sample of Kalpvasis (pilgrims who stay at the banks of the Sangam for a month in the holy city of Prayag during the Mela period). One hundred and fifty-four Kalpvasis participated in the study. Positive association between religiosity, happiness and life satisfaction was obtained. Results showed that gender did not have a significant role on these relations in the case of pilgrims. Implications of these results are discussed.
Apolipoprotein A-I (ApoA-I) Mimetic Peptide P2a by Restoring Cholesterol Esterification Unmasks ApoA-I Anti-Inflammatory Endogenous Activity In Vivo

The acute-phase protein haptoglobin (Hpt) binds apolipoprotein A-I (ApoA-I) and impairs its action on lecithin-cholesterol acyltransferase, an enzyme that plays a key role in reverse cholesterol transport. We have previously shown that an ApoA-I mimetic peptide, P2a, displaces Hpt from ApoA-I, restoring the enzyme activity in vitro. The aim of this study was to evaluate whether P2a displaces Hpt from ApoA-I in vivo and whether this event leads to anti-inflammatory activity. Mice received subplantar injections of carrageenan. Paw volume was measured before the injection and 2, 4, 6, 24, 48, 72, and 96 h thereafter. At the same time points, concentrations of HDL cholesterol (C) and cholesterol esters (CEs) were measured by high-performance liquid chromatography, and Hpt and ApoA-I plasma levels were evaluated by enzyme-linked immunosorbent assay. Western blotting analysis for nitric-oxide synthase and cyclooxygenase (COX) isoforms was also performed on paw homogenates. CEs significantly decreased in carrageenan-treated mice during edema development and negatively correlated with the Hpt/ApoA-I ratio. P2a administration significantly restored the CE/C ratio. In addition, P2a displayed an anti-inflammatory effect on the late phase of edema with a significant reduction in COX2 expression coupled to an inhibition of prostaglandin E2 synthesis, implying that, in the presence of P2a, CE/C ratio rescue and edema inhibition were strictly related. In conclusion, the P2a effect is due to its binding to Hpt with consequent displacement of ApoA-I that exerts anti-inflammatory activity. Therefore, it is feasible to design drugs that, by enhancing the physiological endogenous protective role of ApoA-I, may be useful in inflammation-based diseases.
Tipping the Scales of Justice

Rose and Clear propose that neighborhood incarceration, after a tipping-point threshold, can disrupt informal social-control mechanisms in neighborhoods producing more crime and violence. They hypothesize that the incarceration-crime relationship at a neighborhood level is curvilinear. Using suggestions from Hannon and Knapp, the authors assess curvilinearity in the incarceration-crime relationship by comparing results across three different estimation techniques (ordinary least squares, heteroscedasticity consistent covariance matrix [HCCM] for small samples, called HC3, negative binomial). Data from 95 Portland, Oregon, neighborhoods are used for the study. The results are generally consistent and supportive of Rose and Clear’s curvilinearity hypothesis of neighborhood incarceration but only for explanations of violent crime, not property crime. Moderate levels of neighborhood incarceration are related to significant violent crime rate decreases, and high levels of neighborhood incarceration are significantly related to violent crime rate increases. However, models were sensitive to estimation technique and outlying observations. Policy considerations related to concentrated neighborhood incarceration are discussed.
Phase I Study of Copper-Binding Agent ATN-224 in Patients with Advanced Solid Tumors

Purpose: Copper chelation reduces the secretion of many angiogenic factors and reduces tumor growth and microvascular density in animal models. ATN-224 is a second-generation analogue of ammonium tetrathiomolybdate. The aim of our phase I study was to reduce serum copper levels, as measured by ceruloplasmin, to 5 to 15 mg/dL (normal 16-60) in 14 to 21 days, to determine the pharmacokinetic profile of ATN-224 and to evaluate dose-limiting toxicities. Patients and Methods: Cohorts of patients were treated with escalating oral doses of ATN-224 until copper depletion followed by a titrated maintenance dose. Results: Eighteen patients received 78 cycles of ATN-224. Mean baseline ceruloplasmin was 39.6 mg/dL. The maximum administered dose was 330 mg/d where grade 3 fatigue was dose-limiting. At the maximum tolerated dose of 300 mg/d, the median time to achieve target ceruloplasmin was 21 days, and toxicities included grade 3 anemia, grade 3 neutropenia, fatigue, and sulfur eructation. ATN-224 treatment caused a significant reduction (>90%) in RBC superoxide dismutase 1 activity and circulating endothelial cells. Pharmacokinetic data indicate greater absorption of ATN-224 and more rapid ceruloplasmin reduction when administered with a proton pump inhibitor. Stable disease of >6 months was observed in 2 patients. Conclusions: Oral ATN-224 is a well-tolerated therapy and at a loading dose of 300 mg/d leads to a reduction of serum ceruloplasmin levels in 80% patients within 21 days. A loading dose of 300 mg/d for 2 weeks followed by a titrated maintenance dose will be the recommended starting dose for phase II study.
Tropisetron in the prevention of chemotherapy-induced nausea and vomiting: the Nordic experience.

An open, non-comparative, Nordic multicenter study was performed during 1991-1992 to evaluate the new 5-HT3 receptor antagonist tropisetron, as an antiemetic agent in various types of cancer chemotherapy. More than 600 patients were recruited from 16 cancer centers in Sweden, Finland and Denmark. In this report an interim analysis on 231 patients is presented. Gynecological cancers (61%), lung cancer (14%) and breast cancer (7%), were the main diagnoses. In 118 of 231 patients (51%) prior experience of chemotherapy was documented. In 91 patients (39%) cisplatin was part of the cytostatic regimen. Carboplatin (27%), doxorubicin (32%), epidoxorubicin (18%) were also frequently included. In all, 18 cytostatic agents were studied. The median number of courses studied was 3.3 (range 1-15). Overall 153 of 231 patients (67%) were completely protected from acute nausea and vomiting during the first course of chemotherapy. Delayed nausea and vomiting (Days 2-6) were completely controlled in 45%-72%. Treatment efficacy remained stable (57%-89%) over 10 consecutive courses of chemotherapy. For non-cisplatin regimens complete protection was achieved in 78% compared with 51% for cisplatin-regimens (p < 0.0001). Patients with no prior experience of chemotherapy had greater control of acute nausea and vomiting (73%) than patients treated before (61%) in the first course, but not in subsequent courses. There were no such differences in control of delayed nausea and vomiting between chemotherapy-naive and previously treated patients. Sex and age were significant prognostic factors with regard to antiemetic response. Adverse events were recorded in 19%-36% of the cases during long-term follow-up. Headache (16%) and constipation (5%) were most frequent. (ABSTRACT TRUNCATED AT 250 WORDS)
Multifaceted diversity-area relationships reveal global hotspots of mammalian species, trait and lineage diversity.

AIM To define biome-scale hotspots of phylogenetic and functional mammalian biodiversity (PD and FD, respectively) and compare them to 'classical' hotspots based on species richness (SR) only. LOCATION Global. METHODS SR, PD & FD were computed for 782 terrestrial ecoregions using distribution ranges of 4616 mammalian species. We used a set of comprehensive diversity indices unified by a recent framework that incorporates the species relative coverage in each ecoregion. We build large-scale multifaceted diversity-area relationships to rank ecoregions according to their levels of biodiversity while accounting for the effect of area on each diversity facet. Finally we defined hotspots as the top-ranked ecoregions. RESULTS While ignoring species relative coverage led to a relative good congruence between biome top ranked SR, PD and FD hotspots, ecoregions harboring a rich and abundantly represented evolutionary history and functional diversity did not match with top ranked ecoregions defined by species richness. More importantly PD and FD hotspots showed important spatial mismatches. We also found that FD and PD generally reached their maximum values faster than species richness as a function of area. MAIN CONCLUSIONS The fact that PD/FD reach faster their maximal value than SR may suggest that the two former facets might be less vulnerable to habitat loss than the latter. While this point is expected, it is the first time that it is quantified at global scale and should have important consequences in conservation. Incorporating species relative coverage into the delineation of multifaceted hotspots of diversity lead to weak congruence between SR, PD and FD hotspots. This means that maximizing species number may fail at preserving those nodes (in the phylogenetic or functional tree) that are relatively abundant in the ecoregion. As a consequence it may be of prime importance to adopt a multifaceted biodiversity perspective to inform conservation strategies at global scale.
Face-to-Face Communication in an Office Setting

The effects of hierarchical relationships and physical arrangements on face-to-face communication in an office environment were investigated. Mutual exposure, physical distance between offices, chain-of-command distance, and status distance were compared as predictors of communication time. A path model was developed using exposure as a mediating variable between the distance measures and communication time. Exposure was a sufficient predictor of communication. Chain of command, status, and office distance all related to exposure, with chain-of-command distance having the strongest association with exposure. Distance between offices was primarily associated with chain-of-command distance, with status distance having a smaller but significant effect. Results suggest ways in which organizations might manage exposure in order to influence face-to-face communication.
Thyroid Fine Needle Aspiration Biopsies in Children: Study of Cytological-Histological Correlation and Immunostaining with Thyroid Peroxidase Monoclonal Antibodies

Context. There is limited data comparing results of fine needle aspiration biopsies (FNABs) to histological diagnosis in children. Design. FNABs were performed in 707 children and cytological results were compared to histology in 165 cases. The usefulness of immunostaining with anti-TPO monoclonal antibodies (MoAb47) on FNAB samples was examined in 54 operated patients. Results. Among unsatisfactory, benign, suspicious, and malignant FNAB, the histological diagnoses were benign in 12/12 (100%), 69/70 (98.5%), 40/50 (80.0%), and 0/33 (0%), respectively. After surgery, malignancy was established in 44/165 (26.6%) cases. The sensitivity, specificity, and positive and negative predictive values were 95.4%, 55.8%, 61.7%, and 95% with standard FNAB; and 100%, 75%, 73.3, and 100% with MoAb47. Among suspicious FNAB, positive MoAb47 staining was a reliable marker for exclusion of malignancy. Conclusion. Benign and malignant FNAB accurately predict histological diagnosis. In suspicious FNAB, MoAb47 immunostaining may be a useful adjunct to standard cytology.
Two- and Four-Stream Combination Approximations for Computation of Diffuse Actinic Fluxes

Abstract The δ-two- and four-stream combination approximations, which use a source function from the two-stream approximations and evaluate intensities in the four-stream directions, are formulated for the calculation of diffuse actinic fluxes. The accuracy and efficiency of the three computational techniques—the δ-two-stream approximations, the δ-two- and four-stream combination approximations based on various two-stream approaches, and the δ-four-stream approximation—have been investigated. The diffuse actinic fluxes are examined by considering molecular, aerosol, haze, and cloud scattering over a wide range of solar zenith angles, optical depths, and surface albedos. In view of the overall accuracy and computational efficiency, the δ-two- and four-stream combination method based on the quadrature scheme appears to be well suited to radiative transfer calculations involving photodissociation processes.
Subjective Quality Study of Adaptive Streaming of Monoscopic and Stereoscopic Video

Nowadays, HTTP adaptive streaming (HAS) has become a reliable distribution technology offering significant advantages in terms of both user perceived Quality of Experience (QoE) and resource utilization for content and network service providers. By trading-off the video quality, HAS is able to adapt to the available bandwidth and display requirements so that it can deliver the video content to a variety of devices over the Internet. However, until now there is not enough knowledge of how the adaptation techniques affect the end user's visual experience. Therefore, this paper presents a comparative analysis of different bitrate adaptation strategies in adaptive streaming of monoscopic and stereoscopic video. This has been done through a subjective experiment of testing the end-user response to the video quality variations, considering the visual comfort issue. The experimental outcomes have made a good insight into the factors that can influence on the QoE of different adaptation strategies.