Miracle-dz/UniFAR-FTUs huggingface dataset:
Autonomic and Renal Alterations in the Offspring of Sleep-Restricted Mothers During Late Pregnancy

OBJECTIVES: Considering that changes in the maternal environment may result in changes in progeny, the aim of this study was to investigate the influence of sleep restriction during the last week of pregnancy on renal function and autonomic responses in male descendants at an adult age. METHODS: After confirmation of pregnancy, female Wistar rats were randomly assigned to either a control or a sleep restriction group. The sleep-restricted rats were subjected to sleep restriction using the multiple platforms method for over 20 hours per day between the 14th and 20th day of pregnancy. After delivery, the litters were limited to 6 offspring that were designated as offspring from control and offspring from sleep-restricted mothers. Indirect measurements of systolic blood pressure (BPi), renal plasma flow, glomerular filtration rate, glomerular area and number of glomeruli per field were evaluated at three months of age. Direct measurements of cardiovascular function (heart rate and mean arterial pressure), cardiac sympathetic tone, cardiac parasympathetic tone, and baroreflex sensitivity were evaluated at four months of age. RESULTS: The sleep-restricted offspring presented increases in BPi, glomerular filtration rate and glomerular area compared with the control offspring. The sleep-restricted offspring also showed higher basal heart rate, increased mean arterial pressure, increased sympathetic cardiac tone, decreased parasympathetic cardiac tone and reduced baroreflex sensitivity. CONCLUSIONS: Our data suggest that reductions in sleep during the last week of pregnancy lead to alterations in cardiovascular autonomic regulation and renal morpho-functional changes in offspring, triggering increases in blood pressure.
Kultur som friskvård : för ökad känsla av sammanhang

Kan kulturaktiviteter vilka erbjuds genom arbetet, resultera i ett okat valmaende for den anstallde och eventuellt aven en okad kansla av sammanhang? Detta ar utgangspunkten for uppsatsen, som tar .
Rituximab (anti-CD20 monoclonal antibody) for the treatment of patients with relapsing or refractory aggressive lymphoma: a multicenter phase II study.

Rituximab, a chimeric monoclonal antibody that binds specifically to the CD20 antigen, induced objective responses in 50% of patients with low-grade or follicular B-cell lymphoma. Because most nonfollicular B-cell lymphomas also express the CD20 antigen, we conducted a phase II study to evaluate the efficacy and tolerability of this new agent in patients with more aggressive types of lymphoma. Patients with diffuse large B-cell lymphoma (DLCL), mantle cell lymphoma (MCL), or other intermediate- or high-grade B-cell lymphomas according to the Working Formulation were included in this prospective randomized phase II study if they were in first or second relapse, if they were refractory to initial therapy, if they progressed after a partial response to initial therapy, or if they were elderly (age >60 years) and not previously treated. The patients received 8 weekly infusions of rituximab at the dose of 375 mg/m2 in arm A or one infusion of 375 mg/m2 followed by 7 weekly infusions of 500 mg/m2 in arm B. Patients were evaluated 2 months after the last rituximab infusion. Fifty-four patients were randomized from 9 centers in Europe and Australia (28 in arm A and 26 in arm B). A total of 5 complete responses (CR) and 12 partial responses (PR) were observed among the 54 enrolled patients, with no difference between the two doses. In an intent-to-treat analysis, the CR rate was 9% (CI95%, 3% to 20%) and the PR rate was 22% (CI95%, 12% to 36%), for an overall response rate of 31% (CI95%, 20% to 46%). An analysis of prognostic factors showed that response rates were lower in patients with refractory disease, patients with lymphoma not classified as DLCL, and patients with a tumor larger than 5 cm in diameter. DLCL and MCL patients had response rates of 37% and 33%, respectively. The median time to progression exceeded 246 days for the 17 responding patients. The most frequently reported adverse events were related to an infusion syndrome and were mild: 19% of the patients had a grade 3 related adverse event, slightly more in arm B, and only 1 patient had a grade 4 related adverse event in arm A. Two patients (3.7%) withdrew from treatment because of severe adverse events, one patient in each arm. In this first trial of rituximab in DLCL and MCL, patients experienced a significant clinical activity with a low toxicity. Rituximab has significant activity in DLCL and MCL patients and should be tested in combination with chemotherapy in such patients.
The effect of textile knowledge on categorization and stereotyping of textiles

approved: Leslie Davis Burns This study included the development of Textile Knowledge Inventory (TKI) measuring objective Textile Knowledge (TK) and two experiments. From a conceptual analysis, 38 preliminary true-false questions were initially generated. Through item analysis using item-to-item correlation (Cross Product Ratio) and item-to-total correlation (Point Biserial Correlation Coefficients), a 23 item TKI resulted. Validity of TKI was tested by experimental manipulation method. Reliability of TKI was tested by test-retest and internal consistency methods. The first experiment investigated whether Fabric Structure (FS) and level of TK affected categorization of subjects' descriptions of fabric specimens. A nonprobability convenience sampling method was used. Subjects, 93 female college students, received a self-administered questionnaire including one of two FSs (woven or knitted) and the TKI. Subjects were asked to describe the fabric; these descriptions were content analyzed. Multivariate Multi-sample Rank Sum Test found that categorization of subjects' descriptions of fabrics differed as a function of FS and the level of TK. Descriptions of the woven fabric were more likely to be classified as "appearance" category and less likely to be classified as "fiber content" and "texture" categories than the knitted fabric. Descriptions by subjects with Lower TK (LTK) were more likely to be classified as "appearance" and less likely to be classified as "fabric name" than subjects with Higher TK (HTK). The second experiment investigated whether level of TK, fiber content label information, and their interaction caused differences in subjects' descriptions and evaluations of a microfiber polyester fabric. Subjects, 107 female college students, received a self-administered questionnaire including a fabric specimen labeled in "100% polyester", "100% microfiber polyester", or no information. Subjects were asked to describe and evaluate the fabric. Results showed that the negative stereotypic images of polyester tended to influence subjects' evaluations of the fabric specimen. However, subjects with LTK tended to be more influenced by stereotype of polyester than subjects with HTK. Under label conditions of "100% polyester" and "100% microfiber polyester", subjects with LTK evaluated the fabric specimen as lower quality, less attractive, and slightly less expensive than subjects with HTK. Results were discussed as they related to categorization processes. The Effect of Textile Knowledge on Categorization and Stereotyping of Textiles
Glycogen Synthase Kinase 3 Inhibitors in the Next Horizon for Alzheimer's Disease Treatment

Glycogen synthase kinase 3 (GSK-3), a proline/serine protein kinase ubiquitously expressed and involved in many cellular signaling pathways, plays a key role in the pathogenesis of Alzheimer's disease (AD) being probably the link between β-amyloid and tau pathology. A great effort has recently been done in the discovery and development of different new molecules, of synthetic and natural origin, able to inhibit this enzyme, and several kinetics mechanisms of binding have been described. The small molecule called tideglusib belonging to the thiadiazolidindione family is currently on phase IIb clinical trials for AD. The potential risks and benefits of this new kind of disease modifying drugs for the future therapy of AD are discussed in this paper.
Parallel computation of multifield topology: experience of Haskell in a computational science application

Codes for computational science and downstream analysis (visualization and/or statistical modelling) have historically been dominated by imperative thinking, but this situation is evolving, both through adoption of higher-level tools such as Matlab, and through some adoption of functional ideas in the next generation of toolkits being driven by the vision of extreme-scale computing. However, this is still a long way from seeing a functional language like Haskell used in a live application. This paper makes three contributions to functional programming in computational science. First, we describe how use of Haskell was interleaved in the development of the first practical approach to multifield topology, and its application to the analysis of data from nuclear simulations that has led to new insight into fission. Second, we report subsequent developments of the functional code (i) improving sequential performance to approach that of an imperative implementation, and (ii) the introduction of parallelism through four skeletons exhibiting good scaling and different time/space trade-offs. Finally we consider the broader question of how, where, and why functional programming may - or may not - find further use in computational science.
Validation of the Malay Version of Addenbrooke's Cognitive Examination III in Detecting Mild Cognitive Impairment and Dementia

Background/Aims: This study aimed to investigate the validity and reliability of the Malay version of Addenbrooke’s Cognitive Examination III (ACE-III) for detecting mild cognitive impairment (MCI) and dementia. Methods: A total of 152 participants (dementia = 53, MCI = 38, controls = 61) were recruited from two teaching hospitals. The Malay version of ACE-III was translated following the standard guidelines for cross-cultural adaptation of measure. All the participants were assessed with the Malay version of ACE-III and Mini-Mental State Examination (MMSE). Results: The reliability of the Malay version of ACE-III was good with Cronbach’s α coefficient of 0.829 and intraclass correlation coefficient of 0.959. There was a strong positive correlation between the Malay version of ACE-III and MMSE (r = 0.806). Age (r = –0.335) and years of education (r = 0.536) exerted a significant correlation with total score performance. The cutoff score to discriminate dementia from healthy controls was 74/75 (sensitivity = 90.6%, specificity = 82.0%) whereas to discriminate MCI, the cutoff score was 77/78 (sensitivity = 63.2%, specificity = 63.9%). The diagnostic accuracy of ACE-III was higher than that of MMSE in the detection of dementia (area under the curve: ACE-III = 0.929 vs. MMSE = 0.915). Conclusions: The Malay version of ACE-III demonstrated to be a reliable and valid screening tool for dementia.
Perception of object shape in computer graphic displays

that i to reto 000 Abstract. Three-dimensional computer graphic displays contain the information that viewers use to understand the shapes of depicted objects. We have devised techniques for carrying out experiments that examine the factors that influence the accuracy of this shape understanding. We construct simple convex objects using the superquadric equation. The objects are graphically rendered and displayed in rotation in a variety of perceptual tasks. In this paper, we summarize the results of our previous experiments that examined the relative contribution of shading and occluding contour, and the effects of including specular reflectance. We also report experiments designed to determine the influence that light source direction and surface striping have on shape understanding. © 2001 SPIE and IS&T. [DOI: 10.1117/1.1330574]
A Bibliography on Digital and Computational Convexity (1961-1988)

A bibliography of 370 references of books, papers in serial journals, and conference papers, on convexity in relation to computer science is presented. The subject is divided into five topics: (1) convexity and straightness in digital images; (2) convex hull algorithms and their complexity; (3) other computational problems related to convexity; (4) miscellaneous applications; and (5) general mathematical sources. These references range in time from 1961 to September 1988. >
MPEG4 AVC/H.264 decoder with scalable bus architecture and dual memory controller

This paper proposes scalable H.264 video decoder architecture that makes the best use of memory bandwidth, which is the most critical problem during designing real-time multimedia CODEC, and optimizes memory access pattern. The proposed decoder architecture is based on an AHB AMBA system, which uses an ARM core as the main controller, and consists of functional blocks such as: VLD, IDCT, INTER (INTRA) prediction, DF, and Postprocessor. Especially, in order to meet memory bandwidth requirements for each functional block, reference frame memory structure, dual memory controller, and dual bus have been implemented, and the rationale for such design choices has been verified. The H.264 decoder proposed in this paper supports from baseline profile to 1080 HD under 130 MHz.
Liposomal amphotericin B treatment in a 9‐month‐old liver recipient

A 9‐month‐old boy with a suggested candidemia was treated with liposomal amphotericine B (AmBisome, Vestar) after a liver transplant due to an inherited glycogenosis (Pompe's disease). This is believed to be the youngest patient in which this new therapeutic agent has been utilized.
Noise robust speech recognition based on noise-adapted HMMs using speech feature compensation

In conventional VTS-based noisy speech recognition methods, the parameters of the clean HMM are adapted to test noisy speech, or the original clean speech is estimated from the test noisy speech. However, in noisy speech recognition, improved performance is generally expected by employing noisy acoustic models produced by methods such as MTR and MMSR compared with using clean HMMs. In this research, a method was devised that can make use of the noisy acoustic models in the conventional VTS algorithm. A novel mathematical relation was derived between the test and training noisy speech and MMSE of the training noisy speech is obtained from the test noisy speech based on the relation. The proposed method was applied to noise-adapted HMMs trained by the MTR and MMSR and could reduce the relative word error rate by 6.5% and 7.2%, respectively, in the noisy speech recognition experiments on the Aurora 2 database.
A system-wide approach to explaining variation in potentially avoidable emergency admissions: national ecological study

Background Some emergency admissions can be avoided if acute exacerbations of health problems are managed by the range of health services providing emergency and urgent care. Aim To identify system-wide factors explaining variation in age sex adjusted admission rates for conditions rich in avoidable admissions. Design National ecological study. Setting 152 emergency and urgent care systems in England. Methods Hospital Episode Statistics data on emergency admissions were used to calculate an age sex adjusted admission rate for conditions rich in avoidable admissions for each emergency and urgent care system in England for 2008–2011. Results There were 3 273 395 relevant admissions in 2008–2011, accounting for 22% of all emergency admissions. The mean age sex adjusted admission rate was 2258 per year per 100 000 population, with a 3.4-fold variation between systems (1268 and 4359). Factors beyond the control of health services explained the majority of variation: unemployment rates explained 72%, with urban/rural status explaining further variation (R2=75%). Factors related to emergency departments, hospitals, emergency ambulance services and general practice explained further variation (R2=85%): the attendance rate at emergency departments, percentage of emergency department attendances converted to admissions, percentage of emergency admissions staying less than a day, percentage of emergency ambulance calls not transported to hospital and perceived access to general practice within 48 h. Conclusions Interventions to reduce avoidable admissions should be targeted at deprived communities. Better use of emergency departments, ambulance services and primary care could further reduce avoidable emergency admissions.
RANGE AND DIET OF STOATS (MUSTELA ERMINEA )I N A NEW ZEALAND BEECH FOREST

Home range and diet of stoats inhabiting beech forest were examined by trapping and radio tracking. Eleven stoats (6 female, 5 male) were fitted with radio-transmitters. Minimum home ranges of five females averaged 124 ± 21 ha and of four males 206 ± 73 ha. Range lengths of females averaged 2.3 ± 0.3 km and of males 4.0 ± 0.9 km. These differences were not statistically significant. Adult female stoats appeared to have mutually exclusive home ranges. Two females and one male had home ranges that were bisected by the Eglinton River. All three crossed the river regularly and could only have done so by swimming. Bird remains were found in 54% of stoat guts and scats examined, lagomorphs in 33%, and invertebrates in 34%. Australian brushtail possum remains were found in 11% of samples overall, but only in guts and scats from male stoats. A road through the study area affected the behaviour of stoats. Females avoided the road but males preferred it and were found scavenging road-kills, which may explain why they are more frequently found as road-kills themselves. In most years, New Zealand beech forest may be marginal habitat for stoats. No breeding was detected in the year of our study but there had been high productivity in the previous season. Stoats probably survive in this habitat because they are flexible in their diet and because their breeding biology allows them to respond rapidly to a sudden increase in food availability.
Marginal Deformations and Closed String Couplings in Open String Field Theory

We investigate analytic classical solutions in open string field theory which are constructed in terms of marginal operators. In the classical background, we evaluate a coupling between an on-shell closed string state and the open string field. The resulting coupling exhibits periodic behavior as expected from the marginal boundary deformation of background Wilson lines or a marginal tachyon lump. We confirm that the solutions in open string field theory correspond to a class of marginal deformations in conformal field theory.
Dystrophins, Utrophins, and Associated Scaffolding Complexes: Role in Mammalian Brain and Implications for Therapeutic Strategies

Two decades of molecular, cellular, and functional studies considerably increased our understanding of dystrophins function and unveiled the complex etiology of the cognitive deficits in Duchenne muscular dystrophy (DMD), which involves altered expression of several dystrophin-gene products in brain. Dystrophins are normally part of critical cytoskeleton-associated membrane-bound molecular scaffolds involved in the clustering of receptors, ion channels, and signaling proteins that contribute to synapse physiology and blood-brain barrier function. The utrophin gene also drives brain expression of several paralogs proteins, which cellular expression and biological roles remain to be elucidated. Here we review the structural and functional properties of dystrophins and utrophins in brain, the consequences of dystrophins loss-of-function as revealed by numerous studies in mouse models of DMD, and we discuss future challenges and putative therapeutic strategies that may compensate for the cognitive impairment in DMD based on experimental manipulation of dystrophins and/or utrophins brain expression.
Characterization of the Peer Review Network at the Center for Scientific Review, National Institutes of Health

The National Institutes of Health (NIH) is the largest source of funding for biomedical research in the world. This funding is largely effected through a competitive grants process. Each year the Center for Scientific Review (CSR) at NIH manages the evaluation, by peer review, of more than 55,000 grant applications. A relevant management question is how this scientific evaluation system, supported by finite resources, could be continuously evaluated and improved for maximal benefit to the scientific community and the taxpaying public. Towards this purpose, we have created the first system-level description of peer review at CSR by applying text analysis, bibliometric, and graph visualization techniques to administrative records. We identify otherwise latent relationships across scientific clusters, which in turn suggest opportunities for structural reorganization of the system based on expert evaluation. Such studies support the creation of monitoring tools and provide transparency and knowledge to stakeholders.
Woese and Fox: Life, rearranged

(A) Carl Woese examining film on which ribosomal signatures are displayed (2003). (Photo by Jason Lindley; used with permission of the College of Liberal Arts and Sciences, University of Illinois at Urbana–Champaign.) (B) George Fox (1999). (Used with permission of the Department of Biology and Biochemistry at the University of Houston.)
The socioeconomic index in the analysis of large-scale assessments: case study in Baja California (Mexico)

The generalization of assessment instruments for Elementary Education students, at the national and international level, involves the appearance of new techniques in the analysis of statistical results that allow the comparison between geographical areas, schools and students. In this way, the context surveys emerge as measures associated with the achievement tests to control the contextual factors with influence over the students. Although in the literature the socioeconomic level is imposed as a key contextual variable, there is not a particular standard to construct scales of this type at the international level. This study, from an initial sample of 6765 students and 78 educative centers located in Baja California (México), describes the process carried out for the construction of a scale for the socioeconomic level measurement and it validates the results obtained in relation with the "Tests ENLACE", applied to Elementary Education students at the national level. Therefore, this proposal pretends to create a specific model for the construction of these contextual scales of socioeconomic level, taking into account its relation with the own Tests ENLACE. Finally, it is shown the importance of contextual aspects as in the analysis of achievement tests as in the construction of contextual scales included as covariables in this type of analysis.