Miracle-dz/UniFAR-FTUs huggingface dataset:
σLBDR: Congestion-aware logic based distributed routing for 2D NoC

With the advent of multi-core technologies, a significant amount of research has been directed towards running multiple applications concurrently and efficiently. This elevates work load on the network which leads to congestion and subsequently degrades the performance and increases the latency of the network. Table based methods can be used for handling congestion but these methods are not scalable in terms of area. In this paper, we propose a novel routing mechanism that eliminates the need of large routing tables. The results show the performance of σLBDR is better than competing routing algorithms for handling congestion as the area requirement is very less irrespective of the size of the network.
New surgical model of post‐traumatic osteoarthritis: Isolated intra‐articular bone injury in the rabbit

Osteoarthritis (OA) is a leading cause of disability worldwide. We hypothesized that inflammation following isolated intra‐articular bone injury can stimulate post‐traumatic OA and developed a rabbit model to test that concept. Sixty female New Zealand White Rabbits were used. Twenty‐six experimental animals had two holes drilled into their right femoral‐notch, 18 rabbits had sham surgery, and 16 were un‐operated controls. Rabbits were euthanized in subgroups at 72 h, 3, 6, 9, and 52 weeks. Knees were assessed grossly and tissues collected. Cartilage and synovium were analyzed with histology and qPCR and subgroups compared statistically. All surgical joints showed gross and histological (modified Mankin score) cartilage damage after surgery, with experimentals worsening with time (p < 0.05). Cartilage qPCR showed fivefold increases in TGFβ (p < 0.05) expression at 72 h and 3 weeks with sixfold increases in MMP13 (p < 0.025) expression at 72 h. By 6 weeks, expression of these markers was similar to baseline levels. Synovial membrane thickening with increased cellularity was seen at both 9 and 52 weeks (p < 0.05). Short‐term synovial inflammatory marker (IL‐1β, IL‐Ra, IL‐6, and IL‐8) expression was three‐ to fourfold increase in experimentals at 72 h (p < 0.01) returning to baseline levels by 3 weeks. Intra‐articular bone injury creates early joint inflammation with some chronic synovial changes and progressive cartilage damage consistent with OA in adult rabbits. This model provides an exciting new avenue to potentially explore some relevant inflammatory drivers of OA without major mechanical variables. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31: 914–920, 2013
Double Indemnity

That’s a confession by the narrator and hero of “Double Indemnity,” a hardboiled insurance man named Walter Neff (Fred MacMurray) who died because he fell for a great pair of legs. Walter Neff narrates quite a bit of this 1944 Billy Wilder classic, laying out the story of how a routine sales call somehow turned into a steamy adulterous affair with one Phyllis Dietrichson (Barbara Stanwyck), a black-widow blonde who wanted to kill her husband for the insurance money and needed an expert to help maximize her profit. Remarkably enough, he thought he was in love with the woman — and thanks to the doomed romantic charge passing between MacMurray and Stanwyck, audiences nearly believed the feeling was mutual.
Fault-local stabilization : the shortest path tree

We present a fault-local solution to the shortest path tree problem in a rooted network. We consider the case where a transient fault corrupts f nodes (f is unknown, but inferior to half the size of the network) after the tree has been constructed. Our solution allows to recover in less than O (f) time units. If an upper bound k on the number of corrupted nodes is known, the memory space needed depends only on k.
Two novel mutations in the human thyroid peroxidase (TPO) gene: genetics and clinical findings in four children

We report four children originating from two unrelated German families with congenital hypothyroidism (CH) due to mutations in the thyroid peroxidase (TPO) gene. Three female siblings (family 1) were found to be compound heterozygous for two mutations, a known mutation in exon 9 (W527C), and a mutation in exon 8 (Q446H), which has not been described before. In the second family we identified a boy with goitrous CH, who had a novel homozygous mutation in the TPO gene in exon 16 (W873X). All children of family 1 were diagnosed postnatally by newborn screening. The case of the boy of family 2 has already been reported for the in utero treatment of a goiter with hypothyroidism.
“Giants in a Microcosm”

On examination of a breast mass surgically excised in a 69-years-old woman, a pure invasive micropapillary carcinoma (MPC) was diagnosed (Figure 1). At close examination, intensely eosinophilic syncytial-multinucleated giant cells (CD68+) percolating the stromal bands were identified (Figure 1). The breast carcinoma illustrated here shows therefore a combination of 2 rarities, namely, an invasive micropapillary growth pattern and an osteoclast-like giant cell (OGC) component. The World Health Organization blue book classifies the “carcinoma with osteoclast-like stromal giant cells” among rare variants of invasive carcinomas of no special type (IC-NSTs)1; however, OGCs can also accompany a variety of breast cancer special types (cribriform, tubular, mucinous, papillary, lobular, squamous and other metaplastic patterns1,2). Identification of giant cells populating MPCs can be challenging as they feature the same size as the micropapillae and only differ in staining (more eosinophilic cytoplasm) (Figure 1).
Complete genome sequence of Candidatus Ruthia magnifica

The hydrothermal vent clam Calyptogena magnifica (Bivalvia: Mollusca) is a member of the Vesicomyidae. Species within this family form symbioses with chemosynthetic Gammaproteobacteria. They exist in environments such as hydrothermal vents and cold seeps and have a rudimentary gut and feeding groove, indicating a large dependence on their endosymbionts for nutrition. The C. magnifica symbiont, Candidatus Ruthia magnifica, was the first intracellular sulfur-oxidizing endosymbiont to have its genome sequenced (Newton et al. 2007). Here we expand upon the original report and provide additional details complying with the emerging MIGS/MIMS standards. The complete genome exposed the genetic blueprint of the metabolic capabilities of the symbiont. Genes which were predicted to encode the proteins required for all the metabolic pathways typical of free-living chemoautotrophs were detected in the symbiont genome. These include major pathways including carbon fixation, sulfur oxidation, nitrogen assimilation, as well as amino acid and cofactor/vitamin biosynthesis. This genome sequence is invaluable in the study of these enigmatic associations and provides insights into the origin and evolution of autotrophic endosymbiosis.
Effect of plasma protein depletion on BNP-32 recovery.

Depletion of abundant proteins from plasma and serum is an important initial step in many biomarker discovery platforms(1). Decreasing the concentrations of highly abundant proteins (e.g., albumin, IgG, and antitrypsin) facilitates the use of contemporary proteomics technologies, such as gel electrophoresis and mass spectrometry, for detection and identification of low-abundant proteins. Furthermore, decreasing abundant protein concentrations may also improve immunoprecipitation recovery efficiencies for targeted low-abundant species by decreasing nonspecific binding (i.e., shielding the antigen-binding domain) to the antibody and/or solid supports. A notable pitfall to depletion strategies is the potential for unintentionally removing low-abundant plasma or serum proteins. These low-abundant species may be bound specifically or nonspecifically to the depletion ligand, depletion target protein (e.g., carrier proteins), or the solid support(s). Thus, it is important to critically evaluate the effectiveness of abundant plasma protein depletion for enhancing the study of low-abundant protein biomarker(s). We have been actively developing a targeted biomarker discovery platform for characterizing the circulating forms of B-type natriuretic peptide (BNP) that includes protein depletion strategies, immunoprecipitation, gel electrophoresis, isotope dilution (absolute quantification), and nanoflow liquid chromatography coupled to high-performance hybrid Fourier transform mass …
Vena Cava ınvasion by Adrenal Leiomyosarcoma

Primary adrenal mesenchymal tumors are extremely rare. These tumors are hard to diagnose, and similar to certain adrenal tumors, as they do not produce hormones, and they can only manifest themselves when the tumor reaches an advanced size. These tumors are generally detected incidentally. This study reports a rare case of primary leiomyosarcoma of the right adrenal gland with vena cava invasion, in a 70-year-old woman who presented with right flank pain. Computerized tomography showed an adrenal mass with a diameter of 78 mm, which exerted pressure on the vena cava inferior. The invasive part was excised by using adrenalectomy and cavatomy. Tumor invasion was determined on the wall of the vena cava. Histopathological examination on 10× magnification showed 8-10 mitotic events. Immunohistochemical staining showed that the cells were SMA (+), desmin (+), cytokeratin (-), and Bcl-2 (-). The Ki67 proliferation index was 70%. Widespread metastasis developed six months after the adrenalectomy.
Polarimetric mode of MIRAS

The L-band Microwave Imaging Radiometer with Aperture Synthesis (MIRAS), scheduled to be flown as single payload on board the European Soil Moisture and Ocean Salinity (SMOS) mission, has a very wide field of view and synthesizes narrow beams by means of two-dimensional (2-D) interferometry, the same concept used in radio astronomy. Wide field of view is indeed a key feature of this radiometer, which leads naturally to the measurement of the full vector of brightness temperatures of the image. This paper analyzes the theory of polarimetry in the 2-D wide-field-of-view microwave interferometry and describes the way MIRAS will measure the polarimetric brightness temperatures.
Synthetic ion channels.

Progress in the synthesis of membrane-bound ion channels is reviewed. Important results from several groups are highlighted and contributions from the authors' group are summarized. Topics covered include synthetic approaches towards oligo-THF amino acids, oligopyrrolidines and gramicidin hybrid channels. Points of interest are the importance of self-assembly systems, the functional analysis (ion selectivity, gating, asymmetric insertion and asymmetric function) and the structural characterization of the channel.
Functional Recovery of Analog Circuits at Extreme Temperatures

This paper describes a new reconfigurable analog array (RAA) architecture and integrated circuit (IC) used to map analog circuits that can adapt to extreme temperatures under programmable control. Algorithm-driven adaptation takes place on the RAA IC. The algorithms are implemented in a separate Field Programmable Gate Array (FPGA) IC, co-located with the RAA in the extreme temperature environment. The experiments demonstrate circuit adaptation over a wide temperature range, from extremely low temperature of -180 C to high 120 C.
Steady shear and dynamic strain thickening of halloysite nanotubes and fumed silica shear thickening composite

Abstract Developing the shear thickening fluids (STF) which can be used for soft body armours requires an in depth study of various parameters related to its constituents so that a high critical viscosity along with high critical shear rate can be obtained. Shape of the constituting particles is one such important parameter. Elongated and nanosize particles provide high critical viscosity to the fluid, whereas spherical particles show high critical shear rates. STF were prepared using halloysite (Hal) nanotubes of different concentrations with fumed silica (spheres) and their rheological properties were studied. A better non-flocculated structure was obtained at 1% Hal in 20% fumed silica composition, exhibiting a critical viscosity of 25 Pas at a critical shear rate 160 s−1 as compared to that of only spherical particle STF (10 Pas and 200 s−1). The oscillatory tests revealed that this composition, with a better consistent reproducible behaviour and better stability than the STF without Hal, would be suitable as a high impact resistant material. Gel formation does not take place, rather the fluid behaves like a dispersed sol, making it a better choice for using with protective fabrics. The rheology was studied at different temperatures ranging from 0°C to 55°C.
Histochemical reactions of cellular inclusions in the human neurone.

we have reported our findings on neuronal inclusions such as neurosecretory material and lipofuscin pigment in the human hypothalamus, thalamus, motor cortex and cerebellum. Our results, obtained by histological and histochemical methods, indicate first, that neurosecretory material in the hypothalamus is of two varieties, and secondly, that many of the reactions that are generally considered specific for neurosecretory material are also shared by the lipofuscin of neurones outside the hypothalamus. This latter observation implies that the two most widely used histochemical methods for neurosecretion, viz. chrome-haematoxylin and aldehyde fuchsin, do not differentiate between neurosecretory material and lipofuscin, possibly because they possess chemical com-ponents in common that react similarly the used. secretary nuclei and oxytocic hormones the blood stream. for some other type sites acid
Processed allografts and type I collagen conduits for repair of peripheral nerve gaps

Autografting is the gold standard in the repair of peripheral nerve injuries that are not amenable to end‐to‐end coaptation. However, because autografts result in donor‐site defects and are a limited resource, an effective substitute would be valuable. In a rat model, we compared isografts with Integra NeuraGen® (NG) nerve guides, which are a commercially available type I collagen conduit, with processed rat allografts comparable to AxoGen's Avance® human decellularized allograft product. In a 14‐mm sciatic nerve gap model, isograft was superior to processed allograft, which was in turn superior to NG conduit at 6 weeks postoperatively (P < 0.05 for number of myelinated fibers both at midgraft and distal to the graft). At 12 weeks, these differences were no longer apparent. In a 28‐mm graft model, isografts again performed better than processed allografts at both 6 and 22 weeks; regeneration through the NG conduit was often insufficient for analysis in this long graft model. Functional tests confirmed the superiority of isografts, although processed allografts permitted successful reinnervation of distal targets not seen in the NG conduit groups. Processed allografts were inherently non‐immunogenic and maintained some internal laminin structure. We conclude that, particularly in a long gap model, nerve graft alternatives fail to confer the regenerative advantages of an isograft. However, AxoGen processed allografts are superior to a currently available conduit‐style nerve guide, the Integra NeuraGen®. They provide an alternative for reconstruction of short nerve gaps where a conduit might otherwise be used. Muscle Nerve, 2008
Vital pulp therapy using calcium-enriched mixture: An evidence-based review

Worldwide, casecontrol studies have revealed that the treatment outcomes of root canal therapy (RCT) are generally favorable; however, the overall epidemiological success rate of RCT in the general population is relatively low. On the other hand, vitality of dental pulp is a key factor in the long-term prognosis of permanent teeth; in recent years, vital pulp therapy (VPT) has received significant consideration as it has been revealed that the inflamed pulp has the potential to heal. In this review article, the current best evidence with regard to VPT using calcium-enriched mixture (CEM) cement in human permanent/primary teeth is discussed. A strategy based on a search using keywords for CEM cement as well as VPT was applied.
A hybrid dielectrophoretic and hydrophoretic microchip for particle sorting using integrated prefocusing and sorting steps

This work explores dielectrophoresis (DEP)‐active hydrophoresis in sorting particles and cells. The device consists of prefocusing region and sorting region with great potential to be integrated into advanced lab‐on‐a‐chip bioanalysis devices. Particles or cells can be focused in the prefocusing region and then sorted in the sorting region. The DEP‐active hydrophoretic sorting is not only based on size but also on dielectric properties of the particles or cells of interest without any labelling. A mixture of 3 and 10 μm particles were sorted and collected from corresponding outlets with high separation efficiency. According to the different dielectric properties of viable and nonviable Chinese Hamster Ovary (CHO) cells at the medium conductivity of 0.03 S/m, the viable CHO cells were focused well and sorted from cell sample with a high purity.
Semecarpus anacardium Linn.: A review

Semecarpus anacardium Linn. (Family: Anacardiaceae), commonly known ‘Ballataka’ or ‘Bhilwa’, has been used in various traditional system of medicines for various ailments since ancient times. Its nuts contain a variety of biologically active compounds such as biflavonoids, phenolic compounds, bhilawanols, minerals, vitamins and amino acids, which show various medicinal properties. The fruit and nut extract shows various activities like antiatherogenic, antiinflammatory, antioxidant, antimicrobial, anti-reproductive, CNS stimulant, hypoglycemic, anticarcinogenic and hair growth promoter. The article reviews the various activities of the plant.
Systemic Acquired Resistance

In the spectrum of plant-microbe interactions disease is a rare outcome. In many interactions complex, integrated defense mechanisms prevent infection and disease. These defensive systems include preformed physical and chemical barriers as well as inducible defenses such as the strengthening of cell walls or synthesis of antimicrobial compounds (i.e., phytoalexins) and proteins.1,2 In certain cases plants react to pathogen attack by developing long-lasting, broad-spectrum systemic resistance to later attacks by pathogens. This phenomenon, termed systemic acquired resistance (SAR), has been observed in many species and may be ubiquitous among higher plants. In the last five years progress has been made toward understanding the molecular basis of SAR. In this review we first provide a brief history of SAR research, then describe our present knowledge of the manifestation and induction of SAR. We discuss recent findings that indicate a central role for the SAR pathway in plant health and finally present our current working model of SAR induction.
Security Patterns Related to Security Requirements

In the information technology environment, patterns give information system architects a method for defining reusable solutions to design problems. The purpose of using patterns is to create a reusable design element. We can obtain, in a systematic way, a security software architecture that contains a set of security design patterns from the security requirements found. Several important aspects of building software systems with patterns are not addressed yet by today’s pattern descriptions. Examples include the integration of a pattern into a partially existing design, and the combination of patterns into larger designs. Now, we want to use these patterns in our architectures, designs, and implementations.
Principle and Modeling of a Novel Moving Coil Linear-Rotary Electromagnetic Actuator

This paper presents a novel electromagnetic actuator that adopts an air-core coil mover to deliver decoupled linear and rotary motions. It uses light-weight moving coil to achieve high speed and dynamic response, and single-phase Lorentz-force driving scheme to realize direct and noncommutation actuation. To overcome the low thrust force of such driving scheme, unique magnetic circuits are used to enhance the thrust force and torque of the proposed actuator. Closed-form analytical solutions for modeling the magnetic field within the coil operating regions of these unique magnetic circuits are presented together with the complete thermal analyses. A prototype was developed and it delivers 10 mm stroke and 90° angular displacement. Using commercially available drivers, it achieved a high throughput of 8000 units/h with 20 μm, and 0.66° tracking accuracy.
Discriminant Ranking for Efficient Treebanking

Treebank annotation is a labor-intensive and time-consuming task. In this paper, we show that a simple statistical ranking model can significantly improve treebanking efficiency by prompting human annotators, well-trained in disambiguation tasks for treebanking but not necessarily grammar experts, to the most relevant linguistic disambiguation decisions. Experiments were carried out to evaluate the impact of such techniques on annotation efficiency and quality. The detailed analysis of outputs from the ranking model shows strong correlation to the human annotator behavior. When integrated into the tree-banking environment, the model brings a significant annotation speed-up with improved inter-annotator agreement.
IL17eScan: A Tool for the Identification of Peptides Inducing IL-17 Response

IL-17 cytokines are pro-inflammatory cytokines and are crucial in host defense against various microbes. Induction of these cytokines by microbial antigens has been investigated in the case of ischemic brain injury, gingivitis, candidiasis, autoimmune myocarditis, etc. In this study, we have investigated the ability of amino acid sequence of antigens to induce IL-17 response using machine-learning approaches. A total of 338 IL-17-inducing and 984 IL-17 non-inducing peptides were retrieved from Immune Epitope Database. 80% of the data were randomly selected as training dataset and rest 20% as validation dataset. To predict the IL-17-inducing ability of peptides/protein antigens, different sequence-based machine-learning models were developed. The performance of support vector machine (SVM) and random forest (RF) was compared with different parameters to predict IL-17-inducing epitopes (IIEs). The dipeptide composition-based SVM-model displayed an accuracy of 82.4% with Matthews correlation coefficient = 0.62 at polynomial (t = 1) kernel on 10-fold cross-validation and outperformed RF. Amino acid residues Leu, Ser, Arg, Asn, and Phe and dipeptides LL, SL, LK, IL, LI, NL, LR, FK, SF, and LE are abundant in IIEs. The present tool helps in the identification of IIEs using machine-learning approaches. The induction of IL-17 plays an important role in several inflammatory diseases, and identification of such epitopes would be of great help to the immunologists. It is freely available at http://metagenomics.iiserb. ac.in/IL17eScan/ and http://metabiosys.iiserb. ac.in/IL17eScan/.