Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficacy and safety of quadruple therapy including tirofiban in the treatment of Chinese NSTE-ACS patients failing to receive timely percutaneous coronary intervention

Background Although it has been shown to be superior to simple antithrombotic drug therapy, most patients are unable to receive timely percutaneous coronary intervention (PCI) and are treated with conventional triple antithrombotic therapy (aspirin, clopidogrel, low-molecular-weight heparin). Here, we evaluate the efficacy and safety of adding low-dose tirofiban to this regimen. Methods A total of 1,783 patient records (unable to receive PCI) indicating non-ST-segment elevation acute coronary syndrome (NSTE-ACS) were included. A total of 882 received conventional triple antithrombotic therapy; 901 received quadruple antithrombotic therapy. Efficacy was evaluated in terms of major adverse cardiovascular event (MACE) parameters. Safety was evaluated based on the occurrence of bleeding events. Data were collected over a 6-month period post treatment. Results The rate of occurrence of MACE was significantly lower in the quadruple antithrombotic group (10.5% versus 14.1% at 6 months, P=0.02). The log-rank test showed improved survival in the quadruple antithrombotic group. Total bleeding events were higher in the quadruple antithrombotic group (9.7%) than in the triple antithrombotic group (7.1%) (P=0.04); however, this may be attributed to increased clinically insignificant minor bleeding events. Conclusion Quadruple antithrombotic therapy demonstrated a superior alternative for the treatment of high-risk NSTE-ACS patients failing to receive PCI.
Agression: Psychiatric Assessment and Treatment

Models of aggression and impulsivity: phenomenological models of aggression and impulsivity - implications for clinical research and treatment of human aggression, Burr S. Eichelman genetic models of aggression, impulsivity, and related behaviours,C.S. Bergeman and M.A. Montpetit developmental models of aggression, Jennifer E. Lansford, David L. Rabiner, Shari Miller-Johnson, Megan M. Golonka, and Jennifer Hendren biopsychosocial approaches to aggression, Mitchell E. Berman, Michael S. McCloskey,and Joshua J. Broman-Fulks impulsivity, Catherine A. Schmidt. Potential clinical models for disorders of aggression/anger: anger disorders, Jerry L. Deffenbacher anger attacks, Maurizio Fava impulsive aggression, Alan R. Felthous and Ernest S. Barratt intermittent explosive disorder, Emil F. Coccaro. Measures of aggression and impulsivity: questionnaire and interview measures of aggression in adults, Michael S. McCloskey and Emil F. Coccaro laboratory measures - the Taylor aggression paradigm, MichaelS. McCloskey and Mitchell E. Berman laboratory measures - point subtraction aggression paradigm, Don R. Cherek, Scott D. Lane, and Cynthia J. Pietras psychometric measurement of impulsivity, Catherine A. Schmidt laboratory measures of impulsivity,Donald M. Dougherty, Charles W. Mathias, and Dawn M. Marsh measurement of aggression in children and adolescents, Shana E. Cyrulnik, David J. Marks, Jeffrey H. Newcorn, and Jeffrey M. Halperin. Clinical treatment of aggression and impulsive aggression:psychosocial interventions - anger disorders, Jerry L. Deffenbacher psychosocial interventions for intimate-partner violence, Alan Rosenbaum, J. Celeste Walley, and Lori A. Meyerson psychopharmacological interventions - neuroleptics and lithium, RichardP. Malone and Mary Anne Delaney treatment of aggression - serotonergic agents, Royce Lee and Emil F. Coccaro pharmacological interventions - anticonvulsants, Stephen J. Donovan and Jalila B. Aybar.
A New Dynamic Web Server

The growth of traffic on the Internet and the explosion in the number of Web sites created in recent years make Web server performance an important issue for Web site designers. To improve the server's performance, it is necessary to determine the main factors affecting it before proposing new solutions for Web server design. Here we first present some experimental results on factors which influence Web server performance. We show how the number of concurrent clients accessing the server and the overall network traffic dynamics affect the performance. The details of a Web page’s composition are also studied to determine their effect on performance. Then we describe a new approach for developing a Web server,in which the server takes its performance as the clients see it into account and dynamically generates the requested Web pages. Their content depends on the traffic conditions and client capabilities. Some results are described to show the feasibility of our proposed design.
Automatic wrapper induction from hidden-web sources with domain knowledge

We present an original approach to the automatic induction of wrappers for sources of the hidden Web that does not need any human supervision. Our approach only needs domain knowledge expressed as a set of concept names and concept instances. There are two parts in extracting valuable data from hidden-Web sources: understanding the structure of a given HTML form and relating its fields to concepts of the domain, and understanding how resulting records are represented in an HTML result page. For the former problem, we use a combination of heuristics and of probing with domain instances; for the latter, we use a supervised machine learning technique adapted to tree-like information on an automatic, imperfect, and imprecise, annotation using the domain knowledge. We show experiments that demonstrate the validity and potential of the approach.
Automatic Detection of Ornamentation in Flamenco

Ornamentation is a characteristic feature in the melody of m any musical traditions in the world, including flamenco music. There is no universal definition of ornamentation as it is very associated with musical style. In Western classical music, with its lon g-standing analysis tradition, ornamentation has been studied extensively; consider the ornamentat io t bles from Baroque to Romanticism, for example. On the contrary, in spite of the always-heard cl aim that flamenco is very melismatic, scant research have been carried out to define flamenco orname nts. For example, the structural role of flamenco melismas has not been thoroughly described yet, n or its role in style definition.
Asymptotic stability of stochastic reaction-diffusion delayed neural networks

In this paper, we study a new class of stochastic neural networks with reaction-diffusion and time-varying delays. By employing a novel Lyapunov-Krasovskii functional, the Itô's formula, the Green formula and stochastic analysis theory, we obtain a new set of sufficient conditions to ensure Stochastically asymptotic stability of stochastic of the suggested system. Moreover, a numerical example is given to show the effectiveness of the theoretical result.
A Robust Risk Minimization based Named Entity Recognition System

This paper describes a robust linear classification system for Named Entity Recognition. A similar system has been applied to the CoNLL text chunking shared task with state of the art performance. By using different linguistic features, we can easily adapt this system to other token-based linguistic tagging problems. The main focus of the current paper is to investigate the impact of various local linguistic features for named entity recognition on the CoNLL-2003 (Tjong Kim Sang and De Meulder, 2003) shared task data. We show that the system performance can be enhanced significantly with some relative simple token-based features that are available for many languages. Although more sophisticated linguistic features will also be helpful, they provide much less improvement than might be expected.
[A new alkaloids isolated from tetraploidy banlangen].

AIM To investigate the chemical constituents of tetraploidy Banlangen (Isatis indigotica Fort.). METHODS Compounds were separated by chromatography on silica gel. Their structures were determined by spectral analysis and chemical evidence. RESULTS Three compounds were isolated. Their structures were identified as (E)-2-[(3'-indole) cyanomethylene]-3-indolinone (I), 2-(4-hydroxy-3-methoxyphenyl)-4-[(4-hydroxy-3-methoxy-phenyl)-methyl]-3- hydroxymethyl-tetrahydro-furan (II) and 2-methoxy-4-[tetrahydro-4-[(4-hydroxy-3-methoxy-phenyl)-methyl]-3- hydroxymethyl-2-furanyl] phenyl-1-O-beta-D-glucopyranoside (III). CONCLUSION Compound I is a new compound.
Media independent handover enabled advanced mobility management and its functional mapping

In this paper, we propose a suitable set of protocols schematically combining both radio handover and IP handover for heterogeneous network with the enhancement of relay nodes, that is considered as an important feature of the future radio network. Based on that, we develop the functional allocation of media independent handover entities for a 4G communication system developed by the European WINNER project. The allocation is suitable for decentralized radio resource and mobility management as proposed by the system architecture evolution. Performance evaluation of the handover signaling delay for media independent handover enabled relay enhanced cells is presented. Conclusions derived from this work serve as a reference for the design of future radio network and the associated protocols.
Binary integer programming model for university courses timetabling: a case study

It is proposed a binary integer programming model to handle a real instance of the courses-to-professors timetabling problem. The optimization criteria is the preferences of professors by courses and schedules. Besides the common set of constraints, specific features of this situation are considered. A coefficient is introduced to decide about different optimal solutions (alternatively and independently of the approach used in the model). The model was successfully applied in semesters 2014.2 and 2015.1, by the Departamento de Estatística of the Universidade Federal de Pernambuco.
Comments on the Reliability of Lawson and Hanson's Linear Distance Programming Algorithm: Subroutine LDP

This brief paper: (1) Discusses strategies to generate random test cases that can be used to extensively test any Linear Distance Program (LDP) software. (2) Gives three numerical examples of input cases generated by this strategy that cause problems in the Lawson and Hanson LDP module. (3) Proposes, as a standard matter of acceptable implementation procedures, that (unless it is done internally in the software itself, but, in general, this seems to be much rarer than one would expect) all users should test the returned output from any LDP module for self-consistency since it incurs only a small amount of added computational overhead and it is not hard to do.
Research on Image Based on Improved SURF Feature Matching

Image matching is widely used in machine vision, computer technology, industry and agriculture and other fields. Matching the characteristics of traditional methods such as SIFT has advantages of compressed information quantity, high precision, but there are also some deficiencies such as the large of calculation, long time, the object to be measured of position should be required accurately and etc. This paper presents image matching method based on improved SURF feature, and the analysis and comparison are made for the three kinds of image matching methods. The experiment proved: Sometimes it can also be A single SIFT or SURF, The improved SURF more can meet the requirements of parameter estimation accuracy and real-time. It can carry out accurate judgment, recognition for the digital image. It has certain theoretical value and practical value.
On Approximate l1 Systems in Banach Spaces

Let X be a real Banach space and let (f(n)) be a positive nondecreasing sequence. We consider systems of unit vectors (x"i)^~"i"="1 in X which satisfy @? @? "i"@? "A+/-x"i@? >=|A|-f(|A|), for all finite A@? N and for all choices of signs. We identify the spaces which contain such systems for bounded (f(n)) and for all unbounded (f(n)). For arbitrary unbounded (f(n)), we give examples of systems for which [x"i] is H.I. , and we exhibit systems in all isomorphs of @? "1 which are not equivalent to the unit vector basis of @? "1. We also prove that certain lacunary Haar systems in L"1 are quasi-greedy basic sequences.
High-$\kappa$ $\hbox{Al}_{2}\hbox{O}_{3}{-}\hbox{HfTiO}$ Nanolaminates With Less Than 0.8-nm Equivalent Oxide Thickness

High quality nanolaminate stacks consisting of five Al2O3-HfTiO layers with an effective dielectric constant of about 22.5 are reported. A dielectric constant for binary HfTiO thick films of about 83 was also demonstrated. The electrical characteristics of as-deposited structures and ones which were annealed in an O2 atmosphere at up to 950 degC for 5-10 min were investigated. Two types of gate electrodes: Pt and Ti were compared. The dielectric stack which was annealed up to 500 degC exhibits a leakage current density as small as ~1times10-4 A/cm2 at an electric of field 1.5 MV/cm for a quantum-mechanical corrected equivalent oxide thickness of ~0.76 nm. These values change to ~1times10-8 A/cm2 and 1.82 nm, respectively, after annealing at 950 degC
Analysis of Chaos and Bifurcation Due to Slotting Effect and Commutation in a Current Discontinuous Permanent Magnet Brushed DC Motor Drive

The aim of this paper is to study the dynamics of a permanent magnet direct current (PMDC) brushed motor while two crucial space-domain effects, namely, slotting effect and commutation phenomenon are taken into account. Semi-analytical dynamic time-domain PMDC brushed motor model inclusive of these space-domain effects is used to analyze and investigate the dynamics. Pulse width modulation operated discontinuous current PMDC brushed motor drive with steady duty cycle is employed to acquire the bifurcation patterns. The chaotic nature due to slotting effect and commutation is identified from the bifurcation patterns and reported. It also has to be admired that such nonlinear dynamical behavior with the same set of parameters at similar operating condition has not been observed when a conventional PMDC brushed motor dynamic model is considered. These space-domain effects, namely, slotting effect and commutation also have a prominent impact to make some time-domain states of a PMDC brushed motor drive chaotic. The role of slotting effect and commutation phenomenon to analyze the chaos over time-domain state variables of the PMDC brushed motor drive is investigated and validated experimentally in this paper.
Waveform optimization for compressive sensing radar imaging

The compressive sensing radar (CSR) has been demonstrated to provide high-quality radar images using fewer data samples than conventional methods. Similar to traditional radar systems, the imaging performance of CSR is also affected by the transmitted waveform. Since a direct optimization of the sensing matrix with respect to the waveform is prohibitive, a CSR waveform design method minimizing a weighted coherence of the sensing matrix is proposed in this paper. A universal CSR model is first established and the cost function for waveform optimization is derived. Then, the simulated annealing (SA) algorithm is introduced to reduce the cost function with binary phase-coded waveform as an example. The proposed algorithm generates the waveform with smaller coherence and inner products compared to the other waveforms widely used in literatures, thus can achieve better performance with superresolution and high accuracy in the CS imaging formation.
A fully integrated dual-channel log-domain programmable preamplifier and filter for an implantable cardiac pacemaker

A programmable-gain preamplifier and filter for detection of spontaneous heart activity in an implantable cardiac pacemaker is presented. The system is fully integrated in a standard 0.35-/spl mu/m CMOS technology, including all auxiliary circuits. Two channels are available in order to process both atrial and ventricular signals. CMOS translinear circuits, with particular emphasis on log-domain techniques, have been exploited in order to contain current consumption and to allow correct operation with a reduced supply voltage, due to battery discharging. Indeed, the realized system can operate down to 1.8 V of supply voltage and dissipates at most 1.8 /spl mu/A, granting at least 47 dB of dynamic range (DR) for the atrial chain, which is compatible with advanced digital sensing. Current consumption can be further reduced at the expense of DR if a simpler sensing like peak detection is adopted. All system performance have been verified by measurements results and are compatible with the requirements of cardiac pacemakers. This work, therefore, demonstrates how a proper design approach, exploiting low-power and low-voltage techniques, allows one to optimize performance for the cardiac pacemaker.
Control-oriented modeling and robust control of a three-phase buck+boost PWM rectifier (VRX-4)

The modeling and control of a three-phase, three-switch buck-type rectifier system with integrated boost output stage (VRX-4) is analyzed in this paper. A cascaded multi-loop control structure is presented that has the following features: constant output voltage for a wide input voltage range and step-wise changes of load; sinusoidal input currents in phase with the mains voltages that also remain sinusoidal in case of asymmetric mains conditions; and active damping of the input filter resonance. For the control design an equivalent DC-DC small-signal model of the converter is derived and verified by simulations and measurements. Based on this and the identification of the critical operating point the controllers for the inner DC current and outer voltage control loops are selected The stability of the closed loop system is discussed and the robust operation of the system is verified by measurements on a 5 kW prototype.
Natural and synthetic prion structure from X-ray fiber diffraction

A conformational isoform of the mammalian prion protein (PrPSc) is the sole component of the infectious pathogen that causes the prion diseases. We have obtained X-ray fiber diffraction patterns from infectious prions that show cross-β diffraction: meridional intensity at 4.8 Å resolution, indicating the presence of β strands running approximately at right angles to the filament axis and characteristic of amyloid structure. Some of the patterns also indicated the presence of a repeating unit along the fiber axis, corresponding to four β-strands. We found that recombinant (rec) PrP amyloid differs substantially from highly infectious brain-derived prions, both in structure as demonstrated by the diffraction data, and in heterogeneity as shown by electron microscopy. In addition to the strong 4.8 Å meridional reflection, the recPrP amyloid diffraction is characterized by strong equatorial intensity at approximately 10.5 Å, absent from brain-derived prions, and indicating the presence of stacked β-sheets. Synthetic prions recovered from transgenic mice inoculated with recPrP amyloid displayed structural characteristics and homogeneity similar to those of naturally occurring prions. The relationship between the structural differences and prion infectivity is uncertain, but might be explained by any of several hypotheses: only a minority of recPrP amyloid possesses a replication-competent conformation, the majority of recPrP amyloid has to undergo a conformational maturation to acquire replication competency, or inhibitory forms of recPrP amyloid interfere with replication during the initial transmission.
Safety of Polyacrylamide 1.5% Left in Anterior Chamber in Combined Phacoemulsification and Pars Plana Vitrectomy Surgery

ABSTRACT Purpose: To evaluate safety, efficacy and postoperative characteristics of polyacrylamide 1.5% ophthalmic viscosurgical device (OVD) left in anterior chamber during and at the end of combined phacoemulsification and pars plana vitrectomy surgery. Materials and Methods: This prospective study comprised 20 eyes that received combined phacoemulsification and pars plana vitrectomy performed by the same surgeon. Polyacrylamide 1.5% was left in anterior chamber at the end of the surgery. Preoperative and postoperative examinations (4, 12 and 24 hours; 14 days; 1 and 3 months) included measurement of intraocular pressure (IOP), central corneal thickness (CCT), endothelial cell density and assessment of any ocular adverse reactions. Results: Four of the 20 patients (20%) showed increased IOP at hours postoperatively and needed medical treatment for IOP control. There was no significant difference in IOP between the preoperative visit and postoperative 3 months (p > 0.05). CCT measurements were similar between preoperative and postoperative visits (p > 0.05). A mean endothelial cell density loss of 6.7% was observed at postoperative day 14, however there was no change after this visit. Conclusion: Polyacrylamide 1.5% is safe, well-tolerated and protective in eyes undergoing combined phacoemulsification and pars plana vitrectomy.
Emetine elicits apoptosis of intractable B-cell lymphoma cells with MYC rearrangement through inhibition of glycolytic metabolism

Despite improved clinical outcomes of diffuse large B-cell lymphoma, a certain proportion of patients still develop a primary refractory disease. To overcome these lymphomas that are intractable to existing treatment strategies, the tumor microenvironment has been identified as a potential therapeutic target. Here we describe our search for effective drugs for primary refractory lymphoma cells with MYC rearrangement. Through the drug screening of 3,440 known compounds, we identified a unique compound, emetine. This compound was effective against lymphoma cells with MYC rearrangement from two different patients that were co-cultured with cancer associated fibroblasts. Emetine induced the death of these cells with a half maximal inhibitory concentration of 312 nM and 506 nM, respectively. Subsequent analyses of the mechanism of action of emetine showed that the drug induced apoptosis of tumor cells via alteration of glucose metabolism through inhibition of hypoxia inducible factor-1α. Moreover, emetine inhibited the potential of cancer associated fibroblasts to support tumor cell viability in vitro and demonstrated significant inhibition of tumor growth in in vivo analyses. Emetine also induced cell death in other primary refractory lymphoma cells with MYC rearrangement. Our combined data indicate that emetine is a potential promising drug for the treatment of intractable lymphomas, which targets both the tumor and its microenvironment.
The union of congruent cubes in three dimensions

A {\em dihedral (trihedral) wedge} is the intersection of two (resp. t hree) half-spaces in $\reals^3$. It is called {\em $\alpha$-fat} if the angle (resp., solid angle) determined by these half-spaces is at least $\alpha>0$. If, in addition, the sum of the three face angles of a trihedral wedge is at least $\gamma >4\pi/3$, then it is called {\em $(\gamma,\alpha)$-substantially fat}. We prove that, for any fixed $\gamma>4\pi/3, \alpha>0$, the combinatorial complexity of the union of $n$ (a) $\alpha$-fat dihedral wedges, (b) $(\gamma,\alpha)$-substantially fat trihedral wedges is at most $O(n^{2+\eps})$, for any $\eps>0$, where the constants of proportionality depend on $\eps$, $\alpha$ (and $\gamma$). We obtain as a corollary that the same upper bound holds for the combinatorial complexity of the union of $n$ (nearly) congruent cubes in $\reals^3$. These bounds are not far from being optimal.