Miracle-dz/UniFAR-FTUs huggingface dataset:
Anti-silencing function 1B promotes the progression of pancreatic cancer by activating c-Myc

The present study aimed to explore the role of histone chaperone anti-silencing function 1B (ASF1B) in pancreatic cancer and the underlying mechanism. The biological function of ASF1B was investigated in pancreatic cancer cell lines (PANC-1 and SW1990) and a mouse xenograft model. Chromatin immunoprecipitation was used to detect the effect of ASF1B on the transcriptional activity of c-Myc. ASF1B was highly expressed in pancreatic adenocarcinoma (PAAD) samples from The Cancer Genome Atlas. ASF1B expression was positively associated with poor survival rates in patients with PAAD. Silencing of ASF1B in PANC-1 and SW1990 cells inhibited cell proliferation, migration and invasion, and induced apoptosis. Mechanistically, ASF1B increased H3K56 acetylation (H3K56ac) in a CREB-binding protein (CBP)-dependent manner. ASF1B promoted H3K56ac at the c-Myc promoter and increased c-Myc expression. In PANC-1 and SW1990 cells, the CBP inhibitor curcumin and the c-Myc inhibitor 10058-F4 reversed the promoting effects of ASF1B on cell proliferation, migration and invasion. In the mouse xenograft model, ASF1B silencing inhibited tumor growth, and was associated with low H3K56ac and c-Myc expression. ASF1B promoted pancreatic cancer progression by activating c-Myc via CBP-mediated H3K56ac.
Lossless backward second-harmonic generation of extremely narrow subdiffractive beams in two-dimensional photonic crystals

We report efficient second harmonic generation using extremely narrow beams (with diameter of the order of the wavelength) that propagate in the self-collimation (or nondiffractive) regime in a two-dimensional photonic crystal. We design and numerically test an AlGaAs photonic crystal membrane, where both fundamental and generated second harmonic beams propagate without diffraction and without out-of-plane losses. The characteristics of the generated second harmonic that is mainly propagating in the backward direction and the conversion efficiency of the proposed scheme are obtained by nonlinear finite-difference time-domain numerical simulations.
Role of land‐surface vegetation in the march of Indian monsoon onset isochrones in a coupled model

Although the Climate Forecast System version‐2 model simulates an overall dry bias in boreal summer mean rainfall over Indian land, the deficiency is particularly prominent over northwest India. The prevailing dryness limits the interannual prediction skill of the Indian summer monsoon rainfall and its subseasonal variability because of poor representation of latent heating due to weak moist convection and the resulting circulation. Here, we show that land‐surface vegetation plays a crucial role in determining the dry bias in the Climate Forecast System version‐2 model. We replaced the land‐surface model's existing vegetation type over India with that derived from recent satellite‐based observations. The modifications helped improve the seasonal mean rainfall over northwest India by 6%. The improvements are especially noticeable during the monsoon season's onset (14%) and withdrawal (10%) phases. Simulations with modified vegetation advanced the onset dates over Kerala, central India, and northwest India closer to that observed. This improvement in the mean onset dates is most prominent over northwest India. Such an improvement was possible owing to a substantial reduction of long rainfall hiatus after onset over Kerala in the simulation with modified vegetation. The modification makes the spatial orientation of monsoon onset isochrones more realistic. We found that although the vertically integrated moisture flux is eastward over most of the Indian monsoon region during its onset phase, its intraseasonal components are westward. In other words, at the intraseasonal time‐scale, moisture propagates against the prevailing low‐level westerlies. This intraseasonal eddy moisture transport advances onset from the Bay of Bengal toward the far northwest parts of the Indian land. The representation of such intraseasonal moisture seepage in the model updated with satellite‐derived vegetation types was improved. Our study indicates the necessity of greater attention to land‐surface representations for improved predictions of onset dates.
Projective phase measurements in one-dimensional Bose gases

We consider time-of-flight measurements in split one-dimensional Bose gases. It is well known that the low-energy sector of such systems can be described in terms of two compact phase fields \hat{\phi}_{a,s}(x)ϕ̂a,s(x). Building on existing results in the literature we discuss how a single projective measurement of the particle density after trap release is in a certain limit related to the eigenvalues of the vertex operator e^{i\hat{\phi}_a(x)}eiϕ̂a(x). We emphasize the theoretical assumptions underlying the analysis of “single-shot” interference patterns and show that such measurements give direct access to multi-point correlation functions of e^{i\hat{\phi}_a(x)}eiϕ̂a(x) in a substantial parameter regime. For experimentally relevant situations, we derive an expression for the measured particle density after trap release in terms of convolutions of the eigenvalues of vertex operators involving both sectors of the two-component Luttinger liquid that describes the low-energy regime of the split condensate. This opens the door to accessing properties of the symmetric sector via an appropriate analysis of existing experimental data.
Influence of the Dzyaloshinskii-Moriya interaction on the FMR spectrum of magnonic crystals and confined structures

We study the effect of surface-induced Dzyaloshinskii-Moriya interaction (DMI) on the ferromagnetic resonance (FMR) spectrum of thickness-modulated one-dimensional magnonic crystals and isolated stripes. The DMI is found to substantially increases the intensity of absorption peaks and shifts the frequencies of the laterally quantized modes. The role of the DMI is determined by analyzing the amplitude and phase distributions of dynamic magnetic excitations calculated with frequency- and time-domain calculation methods. We propose experimentally realizable magnonic crystals and confined structures with multiple FMR absorption peaks. The frequency or magnetic field separation between FMR lines is exploited to propose a method for estimation of the DMI strength.
Effects of Nut Consumption on Cardiovascular Risk Factors and Coronary Heart Diseases

Background: Intervention and epidemiological studies have shown that nut consumption has beneficial effects on cardiovascular risk factors, such as hypertension, type 2 diabetes, body mass index, and hyperlipidemia. The aim of this review is to investigate the effects of nut consumption on cardiovascular risk factors and coronary heart diseases. In addition, we investigated possible mediating mechanisms through which nuts act with health protective effects, which could have a preventive effect on cardiovascular risk factors and coronary artery diseases.Method: We collected accredited international investigations, whether original, review, meta-analysis that published data in Google Scholar, PubMed/Medline, Wiley Online Library, Web of Science, Science Direct, Scopus, and Research Gate databases.Result:Some human studies and most animal and laboratory studies reported that favorable effects of nut consumption on cardiovascular risk factors and diseases are through their nutrient profile including polyphenols, unsaturated fatty acid, vitamins, phytosterols, minerals, fibers, and protein. Nut nutrient profile could act through reduction inflammation, inhibition oxidative stress, gut microbiota modification, improvement of endothelial function, modulating gene expression, miRNA, adipokines, insulin secretion, lipid and glucose metabolism, and decreasing cholesterol absorption.Conclusion:Nuts have favorably acted on lipid profile, glucose homeostasis, vascular health, and weight control. Furthermore, human clinical trials are needed to find the exact and most effective pathways by which nuts prevent or reduce cardiovascular risk factors.Keywords: Nut Consumption, hypertension, type 2 diabetes, body mass index, hyperlipidemia
The Distribution and Excitation of CH3CN in a Solar Nebula Analog

Cometary studies suggest that the organic composition of the early Solar Nebula was rich in complex nitrile species such CH3CN. Recent ALMA detections in protoplanetary disks suggest that these species may be common during planet and comet formation, but connecting gas-phase measurements to cometary abundances first requires constraints on formation chemistry and distributions of these species. We present here the detection of seven spatially resolved transitions of CH3CN in the protoplanetary disk around the T-Tauri star TW Hya. Using a rotational diagram analysis, we find a disk-averaged column density of cm−2 and a rotational temperature of K. A radially resolved rotational diagram shows the rotational temperature to be constant across the disk, suggesting that the CH3CN emission originates from a layer at z/r ∼ 0.3. Through comparison of the observations with predictions from a disk chemistry model, we find that grain-surface reactions likely dominate CH3CN formation and that in situ disk chemistry is sufficient to explain the observed CH3CN column density profile without invoking inheritance from the protostellar phase. However, the same model fails to reproduce a solar system cometary abundance of CH3CN relative to H2O in the midplane, suggesting that either vigorous vertical mixing or some degree of inheritance from interstellar ices occurred in the Solar Nebula.
Perceived Value of Online Services: Scale Validation and Managerial Implications

Marketing literature states perceived value is crucial in predicting customer choice in marketing literature. However, perceived value of online services can be different from its offline counterpart due to its temporal and spatial nature, which has been relatively under-researched, where a lacuna of theoretical frameworks and well-accepted measurement scales exists. This paper addresses the above research gap by developing a 19-item measurement scale that can be used to assess perceived value of online services. Data collected from a questionnaire survey of 147 customers of hotels in Sri Lanka were used to assess the reliability and validity of the proposed scale in a post-purchase situation, using exploratory and confirmatory factor analyses. The findings produces six value dimensions (conditional, epistemic, social, monetary, convenience and emotional value) all of which were found to demonstrate acceptable psychometric properties based on a variety of reliability and validity tests. Managerial and theoretical implications stemming from the empirical findings are also discussed.
Supersymmetric gauged 
U(1)Lμ−Lτ
 model for neutrinos and the muon (
g−2
) anomaly

The gauged $U(1)_{L_{\mu}-L_{\tau}}$ model can provide for additional contributions to the muon anomalous magnetic moment by means of a loop involving the $Z^{\prime}$ gauge boson. However, the parameter space of such models is severely constrained if one combines the latest muon $(g-2)$ data with various neutrino experiments, such as neutrino trident production, $\nu -e$ and $\nu -q$ elastic scattering, etc. In a supersymmetric $U(1)_{L_{\mu}-L_{\tau}}$ model, a larger region of parameter space opens up, thus enabling one to explore otherwise forbidden regions of parameter space in nonsupersymmetric models involving the new gauge coupling ($g_X$) and the mass of the $Z^\prime$ gauge boson ($M_{Z^{\prime}}$) . We show that the minimal model with the minimal supersymmetric Standard Model (MSSM) field content is strongly disfavored from $Z$-boson decay and neutrino data. We also show that the nonminimal model with two extra singlet superfields can lead to correct neutrino masses and mixing involving both tree-level and one-loop contributions. We find that, in this model, both muon $(g-2)$ and neutrino data may be simultaneously explained in a parameter region consistent with experimental observations. In addition, we observe that the muon $(g-2)$ anomaly can be accommodated even with higher values of electroweak sparticle masses compared to the MSSM. Charged lepton-flavor-violating processes (like $\mu\rightarrow e\gamma$, $\tau\rightarrow \mu\gamma$, etc.) may have potentially large branching ratios in this scenario. Depending on the magnitude of the supersymmetry contribution to these processes, they may constrain hitherto unconstrained regions of the $M_{Z^{\prime}}-g_X$ parameter space. However, we find that these branching fractions never exceed their upper bounds in a region where both muon $(g-2)$ and neutrino oscillation data can be simultaneously accommodated.
The WARPS Survey. VI. Galaxy Cluster and Source Identifications from Phase I

We present in catalog form the optical identifications for objects from the first phase of the Wide Angle ROSAT Pointed Survey (WARPS). WARPS is a serendipitous survey of relatively deep, pointed ROSAT observations for clusters of galaxies. The X-ray source detection algorithm used by WARPS is Voronoi Tessellation and Percolation (VTP), a technique which is equally sensitive to point sources and extended sources of low surface brightness. WARPS-I is based on the central regions of 86 ROSAT PSPC fields, covering an area of 16.2 square degrees. We describe here the X-ray source screening and optical identification process for WARPS-I, which yielded 34 clusters at 0.06 < z < 0.75. Twenty-two of these clusters form a complete, statistically well-defined sample drawn from 75 of these 86 fields, covering an area of 14.1 square degrees, with a flux limit of F(0.5 × 2.0 keV) = 6.5 × 10-14 erg cm-2 s-1. This sample can be used to study the properties and evolution of the gas, galaxy and dark matter content of clusters and to constrain cosmological parameters. We compare in detail the identification process and findings of WARPS to those from other recently published X-ray surveys for clusters, including RDCS, SHARC-Bright, SHARC-south, and the CfA 160 deg2 survey.
The Free Energy and the Scaling Function of the Ferromagnetic Heisenberg Chain in a Magnetic Field

A nonlinear susceptibilities (the third derivative of a magnetization m S by a magnetic ﬁeld h ) of the S =1/2 ferromagnetic Heisenberg chain and the classical Heisenberg chain are calculated at low temperatures T. In both chains the nonlinear susceptibilities diverge as T − 6 and a linear susceptibilities diverge as T − 2 . The arbitrary spin S Heisenberg ferromagnet [ H = P Ni =1 {− J S i S i +1 − ( h/S ) S zi } ( J > 0) , ] has a scaling relation between m S , h and T : m S ( T, h ) = F ( S 2 Jh/T 2 ) . The scaling function F ( x )=(2 x /3)-(44 x 3 /135) + O( x 5 ) is common to all values of spin S.
From Deprivation to Capital - Spirituality and Spiritual Yearning as Recovery Capital from PTSD

ABSTRACT Trauma and its consequences, such as PTSD, have been thoroughly researched in recent years. Spirituality, religious and non-religious alike, has been used for a variety of purposes by humanity, including recovery from trauma and its consequences. However, spirituality’s role in maintaining the recovery of people with PTSD has not yet been sufficiently researched. This qualitative study attempts to fill the gap through interviews with 50 individuals from different backgrounds who recovered from PTSD and who attributed their recovery to spirituality; however, each of them went through their own traumas, had different piety levels, and used different recovery methods. The results show that spirituality can serve as recovery capital for those dealing with trauma and PTSD: the transition between spiritual deprivation and active spiritual yearning initiates a process of recovery and the acquisition of ‘spiritual recovery capital. ’ Spiritual recovery capital has unique characteristics, accumulates as recovery progresses, and was even found among those who did not see themselves as spiritual before their trauma(s) and PTSD diagnosis. The research shows that spirituality can be useful for trauma survivors and therapists at all stages of recovery and can also promote maintaining recovery.
Recreational Evaluation of Forests in Urban Environments: Methodological and Practical Aspects

This literature review shows that there is no up-to-date common approach to assess the recreational potential of forests. The aim of the study is to present methodological and practical aspects of the evaluation of forests in urban environments for recreational purposes based on the example of urban forests in Poznań (Poland). In this research, the following evaluation criteria were selected: types of forest habitats, ages of dominant species, stand composition, stocking index, the share of undergrowth, soil cover, canopy closure, and surface water. All these criteria are presented in the forest management plan (FMP). We prove that the majority of stands within the study area (81.86%) have medium potential for recreational purposes. Moreover, regarding recreation services, documents existing within the study area are not specified enough. The undoubted advantages of the proposed method are a forestry perspective on the problem, a uniform dataset included in FMPs, data availability, and the possibility of comparing data from different areas.
Kondo resonances and Fano antiresonances in transport through quantum dots

The transmission of electrons through a noninteracting tight-binding chain with an interacting side quantum dot (QD) is analyzed. When the Kondo effect develops at the dot the conductance presents a wide minimum, reachingzero at the unitary limit. This result is compared to the opposite behavior found in an embedded QD. Application of a magnetic field destroys the Kondo effect and the conductance shows pairs of dips separated by the charging energy U. The results are discussed in terms of Fano antiresonances and explain qualitatively recent experimental results.
The Performance Measurement Instrument of Forest Management Units in KPHP Unit XVI Jeneberang I Work Area, South Sulawesi: A Case Study in Indonesia

Performance indicators are quantitative and/or qualitative measures that describe the level of achievement of a predetermined target or goal. Measurement of the level of achievement or performance measurement of FMU management aims to see how far the implementation of forest management is at the stall level. In measuring the performance of the FMU, an instrument is needed as a tool to evaluate the level of achievement of forest management carried out by the FMU. This research was conducted to formulate an instrument that can be used in measuring the performance level of FMU, especially in KPHP Unit XVI Jeneberang I. The results showed that there were 3 categories of performance measurement, namely input performance, process performance, and output performance. Overall, there are 27 KPIs with 6 KPIs for input performance, 11 KPIs for process performance and 10 KPIs for output performance.
Morphology-regulated core–shell Ag@Au NPs for rapid SERS detection of 1-amino-hydantoin (AHD) in crayfish

ABSTRACT Gold-coated silver core–shell nanoparticles (Ag@Au NPs) have been widely used for SERS analysis due to plasmon resonance performances. However, it is a great challenge to fabricate Ag@Au core–shell structures with specified morphology. In this paper, the size and shape of Ag NPs (core) were precisely controlled by a seed-mediated approach, and then the gold shell was completely coated on under the strong reduction of ascorbic acid, resulting in Ag@Au NPs with highly regulated morphology. The obtained Ag@Au NPs achieved a similar or even better SERS enhancement factor (EF) (up to 5.7 × 107) compared to Ag NPs, but significantly higher stability. For the rapid SERS detection of nitrofurantoin metabolite AHD, a limit of detection (LOD) as low as 1 × 10−10 M and a wide linear range from 1 × 10−4 to 1 × 10−8 M were obtained. Furthermore, recoveries for crayfish samples were from 90.5% to 108%, indicating a good performance of the presented method in real sample detection.
Commensurate and incommensurate vortex lattice melting in periodic pinning arrays

We examine the melting of commensurate and incommensurate vortex lattices interacting with square pinning arrays through the use of numerical simulations. For weak pinning strength in the commensurate case we observe an order-order transition from a commensurate square vortex lattice to a triangular floating solid phase as a function of temperature. This floating solid phase melts into a liquid at still higher temperature. For strong pinning there is only a single transition from the square pinned lattice to the liquid state. For strong pinning in the incommensurate case, we observe a multistage melting in which the interstitial vortices become mobile first, followed by the melting of the entire lattice, consistent with recent imaging experiments. The initial motion of vortices in the incommensurate phase occurs by an exchange process of interstitial vortices with vortices located at the pinning sites. We have also examined the vortex melting behavior for higher matching fields and find that a coexistence of a commensurate pinned vortex solid with an interstitial vortex liquid occurs while at higher temperatures the entire vortex lattice melts. For triangular arrays at incommensurate fields higher than the first matching field we observe that the initial vortex motion can occur through a correlatedmore » ring excitation where a number of vortices can rotate around a pinned vortex. We also discuss the relevance of our results to recent experiments of colloidal particles interacting with periodic trap arrays. « less
USA Experiment Observation of Spectral and Timing Evolution during the 2000 Outburst of XTE J1550–564

We report on timing and spectral observations of the 2000 outburst of XTE J1550-564 made by the Unconventional Stellar Aspect (USA) experiment on board the Advanced Research and Global Observation Satellite (ARGOS). We observe a low-frequency quasi-periodic oscillation with a centroid frequency that tends to increase with increasing flux and a fractional rms amplitude that is correlated with the hardness ratio. Several high-frequency quasi-periodic oscillations were detected by Rossi X-Ray Timing Explorer during periods where the low-frequency quasi-periodic oscillation was seen to be weakening or not detectable at all. The evolution of the hardness ratio (4-16 keV/1-4 keV) with time and source flux is examined. The hardness-intensity diagram shows a cyclical movement in the counterclockwise direction and possibly indicates the presence of two independent accretion flows: a thin-disk flow and a hot sub-Keplerian flow.
Accelerated tidal circularization via resonance locking in KIC 8164262

Tidal dissipation in binary star and planetary systems is poorly understood. Fortunately, eccentric binaries known as heartbeat stars often exhibit tidally excited oscillations, providing observable diagnostics of tidal circularization mechanisms and timescales. We apply tidal theories to observations of the heartbeat star KIC 8164262, which contains an F-type primary in a very eccentric orbit that exhibits a prominent tidally excited oscillation. We demonstrate that the prominent oscillation is unlikely to result from a chance resonance between tidal forcing and a stellar oscillation mode. However, the oscillation has a frequency and amplitude consistent with the prediction of resonance locking, a mechanism in which coupled stellar and orbital evolution maintain a stable resonance between tidal forcing and a stellar oscillation mode. The resonantly excited mode produces efficient tidal dissipation (corresponding to an effective tidal quality factor $Q \sim 5 \times 10^4$), such that tidal orbital decay/circularization proceeds on a stellar evolution time scale.