Miracle-dz/UniFAR-FTUs huggingface dataset:
Acquired hemophilia: a single‐center survey with emphasis on immunotherapy and treatment‐related side‐effects

Abstract: Objectives: Acquired hemophilia is a rare disease caused by the development of autoantibodies against factor VIII. Since 1981 we have observed 17 patients with this disorder in our institution. The objective of this survey was to assess the epidemiological features, clinical course, and mortality rate of these patients, with special emphasis on therapy‐related side‐effects. Also, we present our results with an immunosuppressive approach based on the severity of bleeding episodes. Methods: Clinical records of all patients with acquired hemophilia due to factor VIII inhibitor admitted or referred to our hospital between 1981 and 2001 were reviewed retrospectively. We collected each patient's sex, age, medical history, presenting symptoms, activated partial thromboplastin time, factor VIII activity, and inhibitor titre. Patient's clinical courses, including their bleeding episodes, response to therapy, and therapy‐related side‐effects, were also recorded. Results: Complete and partial responses were achieved in 14 and one patient, respectively (overall response rate 88%) after a median time to complete response of 3.5 months (range 30 d − 25 months). The inhibitor‐related and overall mortality rates were 12% and 29%, respectively. Side‐effects were frequent: two patients had blood‐borne infections, three patients had thrombotic complications, and nine patients had immunosuppressive therapy‐related side‐effects. In five patients, discontinuation of cyclophosphamide or prednisone was required. Conclusions: Although our response rates were remarkable, this survey showed that treatment‐related morbidity could also be very important. Therefore, it is pertinent to bear in mind these potential side‐effects in order to decide the most appropriate therapy for each particular patient.
Females' Perception of Date Rape

This study examined the effect of perceived token resistance and previous sexual contact on women's ability to discriminate when a female wants her partner to stop making sexual advances. Female college students were randomly assigned to one of four conditions. Prior to listening to an audiotaped date rape, participants were told that the couple had been on five dates. Participants were informed that on the previous date the man had manipulated the woman's breasts or genitals. In addition, participants were told the woman did not object to this contact, or the woman initially objected to the contact but subsequently stopped resisting contact. Compared to participants in the no resistance conditions, participants in the perceived token resistance conditions took significantly longer to determine when the man should refrain from attempting further sexual contact. The implications of the findings are discussed.
Skin‐Derived Precursors as a Source of Progenitors for Corneal Endothelial Regeneration

Corneal blindness is the fourth leading cause of blindness in the world. Current treatment is allogenic corneal transplantation, which is limited by shortage of donors and immunological rejection. Skin‐derived precursors (SKPs) are postnatal stem cells, which are self‐renewing, multipotent precursors that can be isolated and expanded from the dermis. Facial skin may therefore be an accessible autologous source of neural crest derived cells. SKPs were isolated from facial skin of Wnt1‐Cre/Floxed EGFP mouse. After inducing differentiation with medium containing retinoic acid and GSK 3‐β inhibitor, SKPs formed polygonal corneal endothelial‐like cells (sTECE). Expression of major corneal endothelial markers were confirmed by Reverse transcription polymerase chain reaction (RT‐PCR) and quantitative Real time polymerase chain reaction (qRT‐PCR). Western blots confirmed the expression of Na, K‐ATPase protein, the major functional marker of corneal endothelial cells. Immunohistochemistry revealed the expression of zonular occludens‐1 and Na, K‐ATPase in cell‐cell junctions. In vitro functional analysis of Na, K‐ATPase pump activity revealed that sTECE had significantly high pump function compared to SKPs or control 3T3 cells. Moreover, sTECE transplanted into a rabbit model of bullous keratopathy successfully maintained corneal thickness and transparency. Furthermore, we successfully induced corneal endothelial‐like cells from human SKPs, and showed that transplanted corneas also maintained corneal transparency and thickness. Our findings suggest that SKPs may be used as a source of autologous cells for the treatment of corneal endothelial disease. Stem Cells Translational Medicine 2017;6:788–798
Low-dose clozapine in acute and continuation treatment of severe borderline personality disorder.

BACKGROUND Psychotic-like symptoms in patients affected by borderline personality disorder (BPD) are usually treated with low-dose neuroleptics, which show controversial acute effects and lead to a worsening of affective-related symptoms and to severe neurologic side effects after prolonged administration. Clozapine lacks the neurologic side effects of traditional neuroleptics and has been shown to successfully treat psychotic-like symptoms in BPD patients at medium dose. We performed an open-label trial of low-dose clozapine in severe BPD patients. METHOD Twelve BPD inpatients (DSM-IV criteria) with severe psychotic-like symptoms were studied. Exclusion criteria included comorbid Axis I and medical pathologies. All patients had followed a therapeutic program without improvement for at least 4 months before admission. The clozapine dose was titrated upward on an individual basis until the complete disappearance of psychotic-like symptoms was achieved. Clinician-rated scales were completed at the beginning of the study and after 4 and 16 weeks. RESULTS All patients completed the 16-week study. Individual clozapine doses ranged from 25 to 100 mg/day. Psychotic-like symptoms decreased within the first 3 weeks of treatment, as confirmed by a statistically significant decrease in Brief Psychiatric Rating Scale scores. This amelioration was coupled with an overall improvement, including a reduction in impulsive behaviors and in affective-related symptoms (Hamilton Rating Scale for Depression) and an increase in global functioning (Global Assessment of Functioning). CONCLUSION Low-dose clozapine for acute and continuation treatment led to improvement in overall symptomatology in a small sample of severe BPD patients.
R&D Policies in France: New Evidence from a NUTS3 Spatial Analysis

The French Policy-mix for R&D and innovation has deeply evolved in recent years and is nowadays, one of the most generous and market-friendly system in the world. This paper investigates the (evolutive) effects of this policy-mix by using a unique database containing information on the amount of R&D tax credit, regional, national and European subsidies received by firms in all French metropolitan NUTS3 regions over the period 2001-2011. By estimating a Spatial Durbin model with regimes and fixed effects, we provide new evidence on the efficiency of the French Policy-mix. First, a yardstick competition between NUTS3 regions for R&D investment driven by negative spatial spillovers is found. Second, it seems that national subsidies are the only instrument able to generate a significant leverage effect on privatelyfinanced R&D. Third, the three other policies studied (Tax Credit, Regional and European subsidies) do not generate significant leverage or crowding-out effect due to spatial effects. Fourth, we highlight the presence of structural breaks in our data that correspond to the last two important reforms of the French tax credit. Consequently, the effect of R&D policies and especially R&D tax credit are likely to change over time and influence ex-post evaluation results.
Circular polarization transmitarray element with linear polarization feed

A dual-resonant quad-layer transmitarray element is proposed in this paper. The element can be used to construct a circularly polarized transmitarray which converts linearly polarized incident wave into circularly polarized outgoing wave. The element operates at 30GHz and is designed through the principle of multilayer frequency selective approach [1]. By varying the element's dimensions, a full transmission phase range of 360° is achieved meanwhile the transmission magnitude is better than -1. 6dB.
Medical and Infectious Waste Management

There is no uniform national standard for defining the wastes that comprise the regulated medical waste (RMW) stream. Based on the variability associated with infectious disease causation, no method exists to determine the potential “infectivity” posed by RMW. Because of this, regulated medical waste definitions developed by the various federal, state, and local government entities are based on the agencies' judgments of risk from the perspective of the jurisdiction to which the definition will apply. It then becomes the responsibility of the regulated community to recognize the various agencies with jurisdiction over definitions and to address the definitional elements of each, recognizing and addressing the inconsistencies that may exist.
A Competency-based Typology of Technology Entrepreneurs: A Systematic Review of the Empirical Studies

Due to the importance of technology entrepreneurs’ competencies in the creation and development of technological businesses, a distinct stream of research has been dedicated to this subject. However, given the nature of suchlike studies, it is difficult to reach a common understanding of the competencies. In fact, there is a need to provide some systematization to achieve advancements in the field. A review of 87 articles indexed on Scopus about technology entrepreneurs indicates that competencies of technology entrepreneurs can be classified under three groups of technological competencies, entrepreneurial competencies, and managerial competencies. This classification is used for two purposes, namely to categorize the technology entrepreneurs based on their competencies and to recommend new venues of research to study technology entrepreneurs. This paper can help technology entrepreneurs develop their competencies. It will also be useful in identifying entrepreneurs, and in training and developing the competency of academic entrepreneurs, technology incubators, and accelerators.
A New Tool for the Neurointensive Care Unit: Simultaneous Measurement of Temperature From a Catheter-Tip Pressure Sensor

Traumatic brain injury is a leading cause of death and permanent disability throughout the world. Over the past 15 years, basic science has made important advances in the understanding of this condition. These advances have not, however, translated into treatment of clinically proven benefit. It has been suggested that individualized care for brain injured patients should include improved monitoring of brain function. For clinical gains to be made, clinicians and researchers require appropriate diagnostic and monitoring tools. In this paper, we describe the novel method of acquiring temperature measurement from a pressure sensor. The method allows concurrent measurements of pressure and temperature. The temperature measurement has a sensitivity of 85.08 mV/°C, across the measurement range 20 °C-45 °C. The time constant of the temperature sensor is 610 ± 55 ms. The mean cross-sensitivity of the temperature signal to changes in pressure is 0.74 m°C/mmHg within the typical physiological pressure range (0-160 mmHg). A method to compensate for this pressure-related error is described. We have evaluated the accuracy of the temperature measurement and the long-term stability of 13 sensors over a period of 28 days. The mean difference between temperature measurements made from the sensors and those made from the reference sensor was <;0.2 °C.
Tumorigenic Poxviruses Up-Regulate Intracellular Superoxide To Inhibit Apoptosis and Promote Cell Proliferation

ABSTRACT Tumorigenic leporipoxviruses encode catalytically inactive homologs of cellular Cu-Zn superoxide dismutase (SOD1). The function of the orthologous myxoma virus M131R and Shope fibroma virus S131R gene products is uncertain, but they inhibit SOD1 activity by a process linked to binding its copper chaperone. Using a superoxide-sensitive dye (hydroethidine), we observed that virus infection increased intracellular superoxide levels in an M/S131R-dependent manner. To see whether this effect promotes infection, we deleted the Shope fibroma virus S131R gene and compared the clinical manifestations of wild-type and mutant virus infections in rabbits. S131RΔ virus produced significantly smaller fibroxanthosarcoma-like growths in vivo and, at a point where these growths were already receding, wild-type infections still showed extensive leukocyte infiltration, necrosis, and fibromatous cell proliferation. Coincidentally, whereas Jurkat cells are protected from mitochondria- and Fas-mediated apoptosis by wild-type myxoma virus in vitro, M131RΔ virus could not block Fas-initiated apoptosis as judged by DNA laddering, terminal deoxynucleotidyltransferase-mediated dUTP-fluorescein nick end labeling, and caspase 3 cleavage assays. These data suggest that tumorigenic poxviruses can modulate intracellular redox status to their advantage to stimulate infected cell growth and inhibit programmed cell death.
A New Type of Combined Element Multiband Frequency Selective Surface

It is well known that a multiband frequency selective surface (FSS) can be obtained by arranging multiple simple apertures in a periodic array. However, this simple combination can not achieve a perfect resonance response in a wide band due to the restriction of the grating lobe frequency determined by the array. A new type of element, the multi periodicity combined element (MPCE), is presented to solve this problem. Its feasibility on restraining the grating lobes is proven by numerical experiments and theoretical analysis. The electromagnetic performance of the MPCEs was studied. The results show that the MPCE FSSs have much weaker grating lobes than the traditional FSSs and their frequency performance can be well predicted through the properties of the member element FSSs. An approximate formula for predicting the transmission coefficients of the grating lobes is provided.
TRIZ-based Anticipatory Design of Future Products and Processes

The capability of anticipating the main features of future products and related manufacturing processes is more and more a critical asset in industry, due to the innovation-based competition of markets and to the extremely reduced lead time of modern product development cycles. The paper presents a survey of TRIZ, the Theory of Inventive Problem Solving, as a reference methodology to support design activities driven by the forecasted evolution of technical systems. TRIZ postulates, models and tools are described in the scope of technology forecasting and discussed within a more general design science perspective. The discussion highlights strengths and weaknesses of the theory and suggests relevant directions for further research in the field.
Bone Response to Static Compressive Stress at Bone-Implant Interface: A Pilot Study of Critical Static Compressive Stress.

PURPOSE Mechanical imbalance caused by mechanical overload or poor bone quality around a dental implant can result in osseointegration failure. To avoid that, it is important to identify an appropriate safety stress margin (critical stress level). For this study, a novel device was developed to generate a quantitative amount of static compressive stress under an aseptic closed condition. The aim was to clarify the amount of critical stress produced on the cortical bone when static compression is applied to the osseointegrated bone-implant interface. MATERIALS AND METHODS Small parts for bone sustaining, load generation, and load transmittance were developed to generate quantitative static compressive stress at the bone-implant interface and implanted inside the tibial cortical bone in adult beagle dogs. Each tibia in two dogs received bone-sustaining parts, then after 2 months, the load-transmitting parts were placed into the bone-sustaining parts. After another 2 months, various magnitudes of static compressive stress (0-180 MPa) were generated by tightening the load-generating part to the osseointegrated bone-implant interface. After 7 days, the animals were euthanized, and dissected blocks were prepared for histomorphometric analyses. RESULTS There were no obvious signs of bone resorption or loss of osseointegration in any of the dogs. The change in shape of osteon was not influenced by the amount of static compressive stress. However, periosteal reactions were observed under the cortical bone on the opposite side. CONCLUSION These results indicate that osseointegrated bone-implant interfaces show minimal response based on the magnitude of static compressive stress, even when such stress is greater than 120 MPa.
A Study on Granger Causality in the CAPM

At the heart of the Capital Asset Pricing Model (CAPM) lies the concept of systematic risk. The systematic risk of a security is that component of the total risk of the security that is explained by market risk. This is captured through the regression of security returns on market returns. The regression coefficient represents the sensitivity of returns of the security to changes in market returns. Current developments in econometric theory, however, undermine the simplicity of this approach. Firstly, there should be some form of causality from changes in market returns to changes in security returns. In particular, Granger causality from market returns to security returns must hold. Secondly, in order for the regression to be meaningful, the time series should be stationary. In particular, the presence of a unit root would undermine the significance of the regression coefficient, and therefore threaten the entire basis of the CAPM. It is in this context that Granger causality and stationarity should be examined for the security line. This approach may be extended to determining the macroeconomic variables that influence asset returns in general.
HEMATOLOGICAL AND BIOCHEMICAL PROFILE IN FEMALE CAMELS (CAMELUS DROMEDARIUS) DURING THE TRANSITION PERIOD

The aim of the present study was to evaluate the hematological and biochemical alterations in female camels during the transition period. Ten apparently healthy camels were randomly selected and subjected to clinical examination. The investigated camels demonstrated no detectable clinical illness and kept under veterinary supervision throughout the study period. A blood sample was collected from each camel for laboratory investigation before and after 2 and 4 weeks of parturition and at time of parturition. Our findings revealed a significant (p=0.001) high values of neutrophils, MCH and MCHC at +14, and a significant (p=0.001) low values of lymphocyte count at -14 and at time of parturition. The globulin concentration increased significantly (p=0.029) at +28. For serum phosphorus and magnesium concentrations, their values were significantly (P< 0.05) elevated at -14 and +28, respectively, while enzymatic activity of liver enzymes including aspartate aminotransferase (AST), γ-glutamyl transferase (GGT) and alkaline phosphatase (ALP) were significantly (P< 005) elevated at +14, while serum activity of GGT and ALP continued at the same pattern at +28. For serum glucose and cortisol concentrations, their values were significantly elevated at (0), while serum creatinine concentrations were significantly (p=0.023) decreased at +14. Estrogen concentration increased significantly at -14 and 0, but decreased significantly at +14 and +28. Progesterone concentrations increased significantly at -14 and decreased at 0, +14 and +28. Other tested parameters did not differ significantly pre- and post-partum. The data presented in this study could be used as a reference guide for female camels during the transition period. Key words : Biochemistry; camel; hematology; transition period
Quaternion-Optimization-Based In-Flight Alignment Approach for Airborne POS

Position and Orientation System (POS) is a key technology that provides motion compensation information for imaging sensor in airborne remote sensing. In-flight alignment (IFA) is an important alignment method that can improve reaction speed and accuracy of measurement for airborne POS. The traditional IFA methods based on the Kalman filter and the adaptive extended Kalman filter (AEKF) are severely affected by flight maneuver; severe maneuver may result in alignment accuracy degeneration or failure. On the basis of optimization-based alignment method for static base alignment, a novel IFA method based on quaternion optimization is devised in this paper, aiming to boost up the robustness and the accuracy of IFA, which extends the range of the application of optimization-based alignment method from static base alignment to IFA. The proposed algorithm has the advantage that it can avoid the affection from severe maneuver. The real-time implementation is given. Flight experiment demonstrates that, compared with the IFA method based on AEKF, the proposed algorithm is better in converging speed and robusticity with the same alignment accuracy.
Ipsilateral cortical connections of primary somatic sensory cortex in rats

The organization of ipsilateral cortical connections of the rat primary somatic sensory area (SI) was analyzed following small injections of multiple fluorescent tracers in the same case, into two or three SI body representations identified electrophysiologically. Labeling patterns were studied in tangential cortical sections and in flattened reconstructions from coronal sections. The cytochrome oxidase staining in tangential sections served as a control for injection location and to position labeling patterns found within granular portion of SI.
Arginine 260 of the Amino-terminal Domain of NR1 Subunit Is Critical for Tissue-type Plasminogen Activator-mediated Enhancement of N-Methyl-D-aspartate Receptor Signaling*

Tissue-type plasminogen activator (tPA) has been involved in both physiological and pathological glutamatergic-dependent processes, such as synaptic plasticity, seizure, trauma, and stroke. In a previous study, we have shown that the proteolytic activity of tPA enhances the N-methyl-d-aspartate (NMDA) receptor-mediated signaling in neurons (Nicole, O., Docagne, F., Ali, C., Margaill, I., Carmeliet, P., MacKenzie, E. T., Vivien, D., and Buisson, A. (2001) Nat. Med. 7, 59–64). Here, we show that tPA forms a direct complex with the amino-terminal domain (ATD) of the NR1 subunit of the NMDA receptor and cleaves this subunit at the arginine 260. Furthermore, point mutation analyses show that arginine 260 is necessary for both tPA-induced cleavage of the ATD of NR1 and tPA-induced potentiation of NMDA receptor signaling. Thus, tPA is the first binding protein described so far to interact with the ATD of NR1 and to modulate the NMDA receptor function.
Analytical sizing of an electrolyser for a small scale wind electrolysis plant

This paper presents an analytic way of sizing an electrolyser by considering the load requirements and efficiencies of the electrolyser, fuel cell and their ancillaries. Current density and the size of the active area of the membrane are optimised to ensure thermal self-sustaining mode of the electrolyser for stand-alone applications. This eliminates the need of heating the feed water. Correlations between the voltages and currents of the generator and the electrolyser are also established. Simulation results for electrolyser parameters are then presented. From these results it can be inferred that by maintaining the current density at 0.8A/cm2, the electrolyser can meet its hydrogen production rate and maintain the temperature in the operating range of 70–90°C.