Miracle-dz/UniFAR-FTUs huggingface dataset:
Fuzzy Keyword Search over Encrypted Data using Symbol-Based Trie-traverse Search Scheme in Cloud Computing

We exploit edit distance to quantify keywords similarity and develop two advanced techniques on constructing fuzzy keyword sets, which achieve optimized storage and representation overheads. We further propose a brand new symbol-based trie-traverse searching scheme, where a multi-way tree structure is built up using symbols transformed from the resulted fuzzy keyword sets. Through rigorous security analysis, we show that our proposed solution is secure and privacy-preserving, while correctly realizing the goal of fuzzy keyword search. Extensive experimental results demonstrate the efficiency of the proposed solution.
Genetic algorithms for communications network design - an empirical study of the factors that influence performance

We explore the use of GAs for solving a network optimization problem, the degree-constrained minimum spanning tree problem. We also examine the impact of encoding, crossover, and mutation on the performance of the GA. A specialized repair heuristic is used to improve performance. An experimental design with 48 cells and ten data points in each cell is used to examine the impact of two encoding methods, three crossover methods, two mutation methods, and four networks of varying node sizes. Two performance measures, solution quality and computation time, are used to evaluate the performance. The results obtained indicate that encoding has the greatest effect on solution quality, followed by mutation and crossover. Among the various options, the combination of determinant encoding, exchange mutation, and uniform crossover more often provides better results for solution quality than other combinations. For computation time, the combination of determinant encoding, exchange mutation, and one-point crossover provides better results.
Occupational sensitization to epoxy resin and reactive diluents in marble workers

10 out of 22 marble workers handling a bicomponent resin, based on epoxy resin and ortho‐cresyl glycidyl ether (CGE), developed Contact dermatitis and airborne contact dermatitis within 20 days to 2 months of exposure. All 22 subjects were patch tested with epoxy resin, bisphenol A, epichlorohydrin and a series of reactive diluents. The 10 symptomatic subjects were all positive to the reactive diluent CGE, and 4 of them also to epoxy resin. The other reactive diluents that gave positive reactions were phenyl glycidyl ether (7 cases), cyclohexanedimethanol glycidyl ether (2 cases), 1,6‐hexanediol diglycidyl ether (2 cases) and allyl glycidyl ether (1 case). The findings of our Study suggest that allergic potential is directly proportional to the electronic charge available, for all electron‐rich molecules (solvents, high and low polymers, reagents) that interact with the glycidyl ether group. Lesser, but still noticeable, effects are detected when activation of the glycidyl group is related to the possible formation of intramolecular hydrogen bonds. In practice, the occupational problem was partly solved by changing the type of glycidyl ether.
Fisher Information and the Fourth Moment Theorem

Using a representation of the score function by means of the divergence operator we exhibit a sufficient condition, in terms of the negative moments of the norm of the Malliavin derivative, under which convergence in Fisher information to the standard Gaussian of sequences belonging to a given Wiener chaos is actually equivalent to convergence of only the fourth moment. Thus, our result may be considered as a further building block associated to the recent but already rich literature dedicated to the Fourth Moment Theorem of Nualart and Peccati. To illustrate the power of our approach we prove a local limit theorem together with some rates of convergence for the normal convergence of a standardized version of the quadratic variation of the fractional Brownian motion.
A First Look at Power Attacks in Multi-Tenant Data Centers

Oversubscription increases the utilization of expensive power infrastructure in multi-tenant data centers, but it can create dangerous emergencies and outages if the designed power capacity is exceeded. Despite the safeguards in place today to prevent power outages, this extended abstract demonstrates that multi-tenant data centers are vulnerable to well-timed power attacks launched by a malicious tenant (i.e., attacker). Further, we show that there is a physical side channel -- a thermal side channel due to hot air recirculation -- that contains information about the benign tenants' runtime power usage. We develop a state-augmented Kalman filter that guides an attacker to precisely time its power attacks at moments that coincide with the benign tenants' high power demand, thus overloading the designed power capacity. Our experimental results show that an attacker can capture 53% of all attack opportunities, significantly compromising the data center availability.
Registered report: A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of selected experiments from a substantial number of high-profile papers in the field of cancer biology. The papers, which were published between 2010 and 2012, were selected on the basis of citations and Altmetric scores (Errington et al., 2014). This Registered Report describes the proposed replication plan of experiments from “A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations” by Sharma and colleagues, published in Cell in 2010 (Sharma et al., 2010). Sharma and colleagues demonstrated that prolonged exposure of cancer cells to TKIs give rise to small populations of “drug tolerant persisters” (DTPs) (Figure 1B-C) that were reversed during subsequent maintenance under drug-free conditions (Figures 1E, 2B and 2E). DTPs exhibited reduced histone acetylation and sensitivity to HDAC inhibitors (HDIs) (Figure 4A-B). Drug sensitivity was restored with co-treatment of either HDIs or an IGF-1R inhibitor, in combination with TKIs (Figure 5A-B). Inhibition of IGF-1R activation also led to decreased KDM5A expression and restoration of H3K4 methylation, suggesting a direct link between the IGF-1R signaling pathway and KDM5A function (Figure 7A, 7C, and 7I). The Reproducibility Project: Cancer Biology is a collaboration between the Center for Open Science and Science Exchange and the results of the replications will be published in eLife. DOI: http://dx.doi. org/10.7554/eLife.09462. 001
FtsZ ring clusters in min and partition mutants: role of both the Min system and the nucleoid in regulating FtsZ ring localization

To understand further the role of the nucleoid and the min system in selection of the cell division site, we examined FtsZ localization in Escherichia coli cells lacking MinCDE and in parC mutants defective in chromosome segregation. More than one FtsZ ring was sometimes found in the gaps between nucleoids in min mutant filaments. These multiple FtsZ rings were more apparent in longer cells; double or triple rings were often found in the nucleoid‐free gaps in ftsI min and ftsA min double mutant filaments. Introducing a parC mutation into the ftsA min double mutant allowed the nucleoid‐free gaps to become significantly longer. These gaps often contained dramatic clusters of FtsZ rings. In contrast, filaments of the ftsA parC double mutant, which contained active MinCDE, assembled only one or two rings in most of the large nucleoid‐free gaps. These results suggest that all positions along the cell length are competent for FtsZ ring assembly, not just sites at mid‐cell or at the poles. Consistent with previous results, unsegregated nucleoids also correlated with a lack of FtsZ localization. A model is proposed in which both the inhibitory effect of the nucleoid and the regulation by MinCDE ensure that cells divide precisely at the midpoint.
Urinary Sodium Is a Potent Correlate of Proteinuria: Lessons from the Chronic Renal Insufficiency Cohort Study

Background: While higher blood pressure is known to increase proteinuria, whether increased dietary sodium as estimated from 24-hour urinary excretion correlates with increased proteinuria in patients with chronic kidney disease (CKD) is not well studied. Methods: We measured 24-hour urinary sodium, potassium and protein excretion in 3,680 participants in the Chronic Renal Insufficiency Cohort study, to determine the relationship between urinary sodium and potassium and urinary protein excretion in patients with CKD. We stratified our data based on the presence or absence of diabetes given the absence of any data on this relationship and evidence that diabetics had greater urinary protein excretion at nearly every level of urinary sodium excretion. Multiple linear regressions were used with a stepwise inclusion of covariates such as systolic blood pressure, demographics, hemoglobin A1c and type of antihypertensive medications to evaluate the relationship between urinary electrolyte excretion and proteinuria. Results: Our data demonstrated that urinary sodium (+1 SD above the mean), as a univariate variable, explained 12% of the variation in proteinuria (β = 0.29, p < 0.0001), with rising urinary sodium excretion associated with increasing proteinuria. The significance of that relationship was only partially attenuated with adjustment for demographic and clinical factors and the addition of 24-hour urinary potassium to the model (β = 0.13, R2 = 0.35, p < 0.0001). Conclusions: An understanding of the relationship between these clinical factors and dietary sodium may allow a more tailored approach for dietary salt restriction in patients with CKD.
Screening for brain aneurysm in the Familial Intracranial Aneurysm study: frequency and predictors of lesion detection.

OBJECT Approximately 20% of patients with an intracranial saccular aneurysm report a family history of intracranial aneurysm (IA) or subarachnoid hemorrhage. A better understanding of predictors of aneurysm detection in familial IA may allow more targeted aneurysm screening strategies. METHODS The Familial Intracranial Aneurysm (FIA) study is a multicenter study, in which the primary objective is to define the susceptibility genes related to the formation of IA. First-degree relatives (FDRs) of those affected with IA are offered screening with magnetic resonance (MR) angiography if they were previously unaffected, are > or = 30 years of age, and have a history of smoking and/or hypertension. Independent predictors of aneurysm detection on MR angiography were determined using the generalized estimating equation version of logistic regression. RESULTS Among the first 303 patients screened with MR angiography, 58 (19.1%) had at least 1 IA, including 24% of women and 11.7% of men. Ten (17.2%) of 58 affected patients had multiple aneurysms. Independent predictors of aneurysm detection included female sex (odds ratio [OR] 2.46, p = 0.001), pack-years of cigarette smoking (OR 3.24 for 20 pack-years of cigarette smoking compared with never having smoked, p < 0.001), and duration of hypertension (OR 1.26 comparing those with 10 years of hypertension to those with no hypertension, p = 0.006). CONCLUSIONS In the FIA study, among the affected patients' FDRs who are > 30 years of age, those who are women or who have a history of smoking or hypertension are at increased risk of suffering an IA and should be strongly considered for screening.
A Compact, Low Power and High Sensitivity E-Band Frequency Divider SiGe HBT MMIC

A compact inductorless E-band static frequency divider with the division ratio of 8 is reported in this paper. It has a sensitivity of -43 dBm at the self-oscillating frequency of 75.3 GHz and sports the sensitivity better than -14 dBm in a frequency range from 70 to 77 GHz. The divider consists of 3 emitter-coupled logic based dividers with the division ratio of 2. High frequency of operation and low power consumption are achieved by introducing a split-resistors load topology, improved by means of a critical interconnections optimization. With these circuit measures, the current consumption of the E-band divider-by-8 can be effectively reduced to 63 mA.
Micronutrients and Anaemia

Micronutrient deficiencies and anaemia remain as major health concerns for children in Bangladesh. Among the micronutrient interventions, supplementation with vitamin A to children aged less than five years has been the most successful, especially after distribution of vitamin A was combined with National Immunization Days. Although salt sold in Bangladesh is intended to contain iodine, much of the salt does not contain iodine, and iodine deficiency continues to be common. Anaemia similarly is common among all population groups and has shown no sign of improvement even when iron-supplementation programmes have been attempted. It appears that many other causes contribute to anaemia in addition to iron deficiency. Zinc deficiency is a key micronutrient deficiency and is covered in a separate paper because of its importance among new child-health interventions.
Atribuciones estereotípicas de calidez y habilidad en jóvenes universitarios

El presente estudio evalua empiricamente el modelo bidimensional sobre el contenido de los estereotipos propuesto Fiske, Cudy, Glick y Xu (2002) en una muestra de 121 estudiantes universitarios costarricenses. Los resultados muestran que las dimensiones de calidez y habilidad representan dos principios basicos de percepcion estereotipica de grupos sociales. Estas dimensiones permiten diferenciar cuatro percepciones estereotipicas (paternalismo, desprecio, envidia y admiracion) y estan asociadas a diversas expectativas, evaluaciones y emociones que regulan las interacciones sociales.
Dependency of cerebral blood flow on mean arterial pressure in patients with acute bacterial meningitis

Objective: Patients with acute bacterial meningitis are often treated with sympathomimetics to maintain an adequate mean arterial pressure (MAP). We studied the influence of such therapy on cerebral blood flow (CBF). Design: Prospective physiologic trial. Setting: The Department of Infectious Diseases, Copenhagen University Hospital, Denmark. Patients: Sixteen adult patients with acute bacterial meningitis. Intervention: Infusion of norepinephrine to increase MAP. Measurements: During a rise in MAP induced by norepinephrine infusion, we measured relative changes in CBF by transcranial Doppler ultrasonography of the middle cerebral artery, recording mean flow velocity (Vmean), and by the arterial to jugular oxygen saturation difference. In 10 out of 16 patients, serial measurements were performed until recovery or death. Individual autoregulation curves were analyzed by a computer program. Autoregulation was classified as impaired if Vmean increased by >10% per 30 mm Hg increase in MAP and if no lower limit of autoregulation was identified by the computer program; otherwise, autoregulation was classified as preserved. Main Results: Initially, Vmean increased from a median value of 46 cm/sec (range, 30‐87 cm/sec) to 63 cm/sec (33‐105 cm/sec) (p < .0001), and arterial to jugular oxygen saturation difference decreased from 0.28 (0.16‐0.51) to 0.21 (0.08‐0.39) (p < .001) when MAP was raised from 69 mm Hg (55‐102 mm Hg) to 110 mm Hg (93‐129 mm Hg). CBF autoregulation was restored in eight of ten patients undergoing serial examination after 7 (range, 2‐10) days. Six of these patients had an uncomplicated course, one had a protracted recovery, and one died. Autoregulation was not restored in two patients; one died and one had a protracted recovery. Conclusion: In patients in the early phase of acute bacterial meningitis, CBF autoregulation is impaired. With recovery from meningitis, the cerebral vasculature regains the ability to maintain cerebral perfusion at a constant level despite variations in MAP.
Circumstellar Hibonite and Corundum and Nucleosynthesis in Asymptotic Giant Branch Stars

We report the discovery of two hibonite grains (CaAl12O19) whose isotopic compositions show that they formed in the winds of red giant and asymptotic giant branch (AGB) stars. While hibonite is the second major phase (after corundum, Al2O3) expected to condense from stellar ejecta with C/O < 1, it has not previously been found. One circumstellar hibonite grain is highly enriched in 17O and slightly depleted in 18O relative to the solar composition and has large excesses in 26Mg and 41K, decay products of 26Al and 41Ca. The inferred initial values (26Al/27Al)0 ≈ 5 × 10-3 and (41Ca/40Ca)0 ≈ 1.5 × 10-4 of this grain are consistent with models of nucleosynthesis in an AGB star. The other hibonite is enriched in 17O, strongly depleted in 18O, shows no evidence of 41Ca and formed with (26Al/27Al)0 ≈ 2 × 10-2. The low 18O/16O and very high (26Al/27Al)0 may indicate substantial proton exposure during cool bottom processing in a low-mass parent star. The low upper limit on 41Ca/40Ca (≤ 3.2 × 10-5) implies that little or no He-shell material had been dredged into the envelope when this grain formed. We also report isotopic compositions for 12 new circumstellar corundum grains. The compositions of 11 of these grains are consistent with current models for red giant and AGB stars. One corundum grain has extremely high 17O/16O and near-solar 18O/16O and may have formed in a star that was initially enriched in 17O and 18O.
Antiproliferative Activity of Methylated Analogues of E- and Z-Resveratrol

Abstract The stilbenoids E-resveratrol (E-3,5,4′-trihydroxystilbene, 1), E-3,5,4′-trimethoxystilbene (2), E-3,4,4′-trimethoxystilbene (3) and E-3,4′-dimethoxy-5-hydroxystilbene (4) were converted by photoisomerization to their corresponding Z-isomers 5D8. Compounds 1D8 were subjected to antiproliferative activity bioassays towards a set of four different human cancer cell lines, namely DU-145 (androgen not responsive human prostate tumor), LNCaP (androgen responsive human prostate tumor), M-14 (human melanoma) and KB (human mouth epidermoid carcinoma). The methylated analogues of 1 are more active than the natural lead in the majority of bioassays. The most active compound was Z-3,5,4′-trimethoxystilbene (6), which showed against DU-145 and LNCaP cells GI50 values close to those of the anticancer drug vinorelbine; 6 resulted more active than its E-isomer 2 towards DU-145, LNCaP and especially KB cell lines. A number of methylated Z-isomers displayed a higher activity than their E-isomers, but E-resveratrol (1) was more active than Z-resveratrol (5) towards all the tested cell lines.
Study of the Clinical Outcome between Traumatic and Degenerative (non-traumatic) Meniscal Tears after Arthroscopic Surgery: A 4-Years Follow-up Study.

INTRODUCTION The meniscus is a biconcave fibrocartilage in the knee joint interpose between the femoral condyles and tibial plateau; the meniscus has functions in load bearing, load transmission, shock absorption joint stability, joint lubrication, and joint congruity. AIM The aim of this study is to provide orthopeadic surgeon a base of reference in the choice of the optimal course of management for meniscal tears. MATERIALS AND METHODS One hundred and seventeen patients met the criteria of inclusion for the present study. Patients were divided in two groups T and NT according to the presence of distinct previous traumatic events to the knees. Two subgroups were formed in each groups T and NT respectively at a mean follow up of 1 and 4 years. Postoperative clinical outcome were assessed using Lysholm scores and Rand SF-36 survey. RESULTS One hundred and seventeen patients were included in the present study with 60(51.28%) patients in the traumatic group and 57(48.71%) in the degenerative group. 95(81.19%) patients in total were satisfied with their health status at end of follow up. The mean value of Lysholm scores at 1 year were respectively 85.25±8.78 for traumatic group and 86.38±12.14 for non-traumatic group and at 4 years were respectively 92.63±7.31 for traumatic group and 72.90±20.77 for non-traumatic group. According to Rand SF-36 health, traumatic group showed better improvements compare to non-traumatic group between 1 and 4 years after arthroscopic meniscus surgery. CONCLUSION A total of 95(81.19%) patients in total were satisfied with their health status at follow up, however, we found that arthroscopy as a treatment for meniscal tear have a relatively better mid-term clinical outcome for traumatic meniscal tears compare to non-traumatic/degenerative meniscal tears.
INTERINDIVIDUAL DIFFERENCES IN NICOTINE METABOLISM AND GENETIC POLYMORPHISMS OF HUMAN CYP2A6

Nicotine is widely consumed throughout the world, and exerts a number of physiological effects. After nicotine is absorbed through the lungs by cigarette smoking, it undergoes extensive metabolism in humans. Nicotine is mainly metabolized to cotinine by cytochrome P450 (CYP) 2A6. CYP2A6 can metabolize some pharmaceutical agents such as halothane, valproic acid, and fadrozole, and activate tobacco-specific nitrosamines. There are large interindividual differences in nicotine metabolism, and it has been found that the interindividual differences are attributed to the genetic polymorphisms of CYP2A6 gene. This review describes the techniques for determination of in vivo nicotine metabolism, characteristics of each human CYP2A6 alleles, and ethnic differences. The relationship between CYP2A6 genetic polymorphism and potency of nicotine metabolism, smoking behavior, and cancer risk are extensively reviewed. Finally, the usefulness of nicotine metabolism for phenotyping of CYP2A6 in individuals and implication of the significance of CYP2A6 genetic polymorphism in a clinical perspective are discussed.
Applying Object Recognition and Tracking to Augmented Reality for Information Visualization

One of the major problems in Augmented Reality (AR) is tracking and registration of both cameras and objects. These tasks must be done accurately to combine real and rendered scenes. In particular, the initialization of the object tracking often remains manual in most systems. Recently, we proposed the use of Bayesian Networks to perform the initialization phase of the tracking. By recognizing the object, special points are taken and we use this information to create generic markers around the scene. Then, an algorithm for pose estimation is used to find the orientation of the real object to allow the registration process for 3D objects. The tracking and registration of both cameras and objects are fundamental tasks specially because some applications may be outdoor. In this paper we demonstrate the capabilities of the proposed method and present some practical examples.