Miracle-dz/UniFAR-FTUs huggingface dataset:
EVALUASI SKENARIO KOORDINASI SUPPLY CHAIN UNTUK MODEL PRICING DAN KEPUTUSAN ORDER/DELIVERY

Model pricing dan keputusan order/delivery merupakan model yang menggabungkan aktivitas penentuan harga (pricing) dan penentuan jumlah unit produk yang harus di order dan delivery. Model gabungan ini akan memaksimalkan keuntungan yang diperoleh oleh supply chain, yaitu melalui peningkatan pendapatan dan meminimalkan biaya yang terlibat seperti biaya pembelian, biaya pemesanan dan biaya handling. Pada penelitian ini akan dikembangkan model matematik pada 2 (dua) skenario yang berbeda, yang menggambarkan karakteristik sistem pada sebuah ritel modern di Surabaya. Pada skenario pertama adalah implementasi model pricing dan keputusan order/delivery pada supply chain ritel modern tanpa koordinasi, dimana pelaku bisnis yang terlibat yaitu DC-Ritel dan Distributor, akan menetapkan keuntungannya masing-masing tanpa mempedulikan keuntungan supply chain secara keseluruhan. Sedangkan pada skenario yang kedua akan dihitung keuntungan model pada skema koordinasi supply chain, yaitu koordinasi antara DC-Ritel-Distributor. Evaluasi model pricing dan keputusan order/delivery dilakukan pada dua skenario tersebut. Nilai-nilai yang digunakan sebagai parameter model diukur dari dua skenario untuk melihat besarnya pendapatan dan biaya-biaya yang dibutuhkan. Dengan menggunakan parameter sebagai ukuran kuantitatif model, skenario koordinasi supply chain dapat menghasilkan keuntungan yang lebih besar dibandingkan dengan skenario tanpa koordinasi.
The clinical course of poorly differentiated thyroid carcinoma (insular carcinoma) - own observations.

INTRODUCTION Poorly differentiated thyroid carcinoma (PDTC, insular carcinoma) occurs rarely. It is described with more aggressive behaviour, poorer prognosis, and higher mortality than well differentiated thyroid carcinoma (WDTC). The aim of this study was to evaluate the clinical course of patients with PDTC, in addition to frequency, clinical stage at the time of diagnosis and the possibility of radical surgical resection, the necessity and kind of complementary treatment, occurrence of distant metastases, and the survival of patients. MATERIAL AND METHODS The study involved 14 patients (9 females, 5 males) diagnosed and treated for PDTC between 2000 and 2009, aged 38 to 78 years. The medical records of patients with PDTC were analyzed to estimate assumed parameters according to the purpose of the study. RESULTS PDTC was diagnosed in 14 among 801 patients with thyroid carcinoma (1.75%). Clinical stages (UICC 2002) at the time of diagnosis were as follows: 3 patients - pT(₁-₂)N(o-x)M(x) (21.5%); 10 patients - pT(₃ ₄)N(x o ₁)M(x-₁)(71.4%); and 1 was unresectable - T(x)N₁M₁ (7.1%). Total thyroidectomy was achieved in 9 patients (64.3%), and 4 patients (28.6%) received non radical surgery. Complementary radioiodine treatment was given to 12 patients (85.8%). Radiation therapy of the neck was applied to 7 patients, palliative radiotherapy of the brain to 1 patient, and chemotherapy to 1 patient. Distant metastases to the lung and to the brain at diagnosis were observed in 2 patients (14.3%). During follow-up of 3-62 months lung metastases were observed in 4 patients (28.6%), three patients were observed above 5 years as disease-recurrence free (21.5%), but in one patient after 5 years and 2 months distant metastases were diagnosed. Three patients died after 2-30 months (21.5%), 2 patients were lost for control, and in the remaining 6 follow-up lasted for less than 5 years. CONCLUSIONS Poorly differentiated thyroid carcinoma is still a challenge both for pathologists and clinicians. Infrequent prevalence, more aggressive course, and poorer prognosis constitute major problems for the clinicians.
A blackboard infrastructure for object-based image interpretation

The paper presents a blackboard infrastructure for the development of object-based image interpretation applications. The infrastructure is based on an abstract deenition of important concepts in image interpretation: data objects, relationships, algorithms, strategies, and models. Building applications with the environment is eeectuated by specializing the abstract concepts. Using abstract concepts as a basis guarantees a high level of extensibility, exibility, and re-usability.
MicroRNA control of myelopoiesis and the differentiation block in acute myeloid leukaemia

•Introduction •MicroRNA control of normal haematopoiesis ‐Haematopoietic stem cell (HSC) ‐Common myeloid progenitor (CMP) and initiation of myelopoiesis ‐Monocyte/macrophage differentiation ‐Granulocytic differentiation ‐Erythroid/megakaryocytic differentiation ‐MicroRNA control of malignant differentiation ‐MicroRNAs associated with abnormal monocytic differentiation ‐MicroRNAs associated with abnormal granulocytic differentiation ‐MicroRNAs associated with abnormal erythroid and megakaryocytic differentiation •Conclusion
Design and analysis of a new 7-DOF parallel type haptic device: PATHOS-II

Most tele-operation to manipulate an object consists of grasping and manipulation, and two or more 6-DOF haptic devices are usually used in master side. In this article, a new simply designed 7-DOF haptic device, PATHOS II is proposed for 1-DOF grasping and 6-DOF manipulation. The merits of a parallel type haptic device such as high stiffness and accuracy are natural characteristics of PATHOS-II with optimized workspace. Due to its unique symmetric structure, the isotropic manipulability is enhanced within the reachable workspace. This parallel type haptic device can be used in applications which need high precision, stiffness and isotropic manipulability.
Observation of ozone enhancement in the lower troposphere over East Asia from a space-borne ultraviolet spectrometer

Abstract. We report observations from space using ultraviolet (UV) radiance for significant enhancement of ozone in the lower troposphere over central and eastern China (CEC). The recent retrieval products of the Ozone Monitoring Instrument (OMI) onboard the Earth Observing System (EOS) Aura satellite revealed the spatial and temporal variation of ozone distributions in multiple layers in the troposphere. We compared the OMI-derived ozone over Beijing with airborne measurements by the Measurement of Ozone and Water Vapor by Airbus In-Service Aircraft (MOZAIC) program. The correlation between OMI and MOZAIC ozone in the lower troposphere was reasonable, which assured the reliability of OMI ozone retrievals in the lower troposphere under enhanced ozone conditions. The ozone enhancement was clearly observed over CEC, with Shandong Province as its center, and was most notable in June in any given year. Similar seasonal variations were observed throughout the 9-year OMI measurement period of 2005 to 2013. A considerable part of this ozone enhancement could be attributed to the emissions of ozone precursors from industrial activities and automobiles, and possibly from open crop residue burning (OCRB) after the winter wheat harvest. The ozone distribution presented in this study is also consistent with some model studies. The lower tropospheric ozone distribution is first shown from OMI retrieval in this study, and the results will be useful in clarifying any unknown factors that influence ozone distribution by comparison with model simulations.
Polyhedral Convexity and the Existence of Approximate Equilibria in Discontinuous Games

Radzik (1991) showed that two-player games on compact intervals of the real line have " { equilibria for all " > 0, provided that payo® functions are upper semicontinuous and strongly quasi-concave. In an attempt to generalize this theorem, Ziad (1997) stated that the same is true for n-player games on compact, convex subsets of Rm, m ¸ 1 provided that we strengthen the upper semicontinuity condition. We show that: 1. the action spaces need to be polyhedral in order for Ziad's ap- proach to work, 2. Ziad's strong upper semicontinuity condition is equivalent to some form of quasi-polyhedral concavity of players' value func- tions in simple games, and 3. Radzik's Theorem is a corollary of (the corrected) Ziad's result.
Tourism, climate change and the mass media: the representation of the issue in Spain

This paper sets out to analyse the information dedicated to climate change and tourism in the Spanish press in the Mediterranean region of the peninsula during the period 1990–2010. Specifically, it seeks to determine the quantitative evolution of media coverage of climate change and tourism and the importance given to this subject. Adequate media attention in both quantitative and qualitative terms could greatly influence public concern and contribute to the social mobilization that will be needed to negotiate/resist the phenomenon in a geographical area in which tourism is a major economic and territorial driver and which is particularly vulnerable to climate change. To construct the corpus, we undertook a systematic analysis of newspaper coverage of tourism and climate change in the media selected; and we carried out content analysis of the 1014 units identified. The results indicate that the coverage is outstanding in quantitative terms. However, the importance given to the subject is quite marginal.
Maximizing IO performance via conflict reduction for flash memory storage systems

Flash memory has been widely deployed during the recent years with the improvement of bit density and technology scaling. However, a significant performance degradation is also introduced with the development trend. The latency of IO requests on flash memory storage systems is composed of access conflict latency, data transfer latency, flash chip access latency and ECC encoding/decoding latency. Studies show that the access conflict latency, which is mainly induced by the slow transfer latency and access latency, has become the dominate part of the IO latency, especially for IO intensive applications. This paper proposes to reduce the flash access conflict latency through the reduction of the transfer and flash access latencies. A latency model is built to construct the relationship among the transfer latency and access latency based on the reliability characteristics of flash memory. Simulation experiments show that the proposed approach achieves significant performance improvement.
Persistence of bat defence reactions in high Arctic moths (Lepidoptera)

We investigated the bat defence reactions of three species of moths (Gynaephora groenlandica, Gynaephora rossi (Lymantriidae) and Psychophora sabini (Geometridae)) in the Canadian Arctic archipelago. Since these moths inhabit the Arctic tundra and, therefore, are most probably spatially isolated from bats, their hearing and associated defensive reactions are probably useless and would therefore be expected to disappear with ongoing adaptation to Arctic conditions. When exposed to bat–like ultrasound (26 kHz and 110 dB sound pressure level root mean square at 1m) flying male Gynaephora spp. always reacted defensively by rapidly reversing their flight course. They could hear the sound and reacted at least 15–25 m away. Psychophora sabini walking on a surface froze at distances of at least 5–7 m from the sound source. However, two out of three individuals of this species (all males) did not respond in any way to the sound while in flight. Hence, we found evidence of degeneration of bat defence reactions, i.e. adaptation to the bat–free environment, in P. sabini but not in Gynaephora spp. Some Arctic moths (Gynaephora spp.) still possess defensive reactions against bats, possibly because the selection pressure for the loss of the trait is such that it declines only very slowly (perhaps by genetic drift) and there may not have been enough time for the trait to disappear. One possible reason may be that Arctic moths have long generation times.
Iatrogenic QT Abnormalities and Fatal Arrhythmias: Mechanisms and Clinical Significance

Severe and occasionally fatal arrhythmias, commonly presenting as Torsade de Pointes [TdP] have been reported with Class III-antiarrhythmics, but also with non-antiarrhythmic drugs. Most cases result from an action on K+ channels encoded by the HERG gene responsible for the IKr repolarizing current, leading to a long QT and repolarization abnormalities. The hydrophobic central cavity of the HERG-K+ channels, allows a large number of structurally unrelated drugs to bind and cause direct channel inhibition. Some examples are dofetilide, quinidine, sotalol, erythromycin, grepafloxacin, cisapride, dolasetron, thioridazine, haloperidol, droperidol and pimozide. Other drugs achieve channel inhibition indirectly by impairing channel traffic from the endoplasmic reticulum to the cell membrane, decreasing channel membrane density (pentamidine, geldalamicin, arsenic trioxide, digoxin, and probucol). Whereas, ketoconazole, fluoxetine and norfluoxetine induce both direct channel inhibition and impaired channel trafficking. Congenital long QT syndrome, subclinical ion-channel mutations, subjects and relatives of subjects with previous history of drug-induced long QT or TdP, dual drug effects on cardiac repolarization [long QT plus increased QT dispersion], increased transmural dispersion of repolarization and T wave abnormalities, use of high doses, metabolism inhibitors and/or combinations of QT prolonging drugs, hypokalemia, structural cardiac disease, sympathomimetics, bradycardia, women and older age, have been shown to increase the risk for developing drug-induced TdP. Because most of these reactions are preventable, careful evaluation of risk factors and increased knowledge of drugs use associated with repolarization abnormalities is strongly recommended. Future genetic testing and development of practical and simple provocation tests are in route to prevent iatrogenic TdP.
Mechanism of Inhibition of Tubuloglomerular Feedback by CO and cGMP

Tubuloglomerular feedback (TGF) is a mechanism that senses NaCl in the macula densa (MD) and causes constriction of the afferent arteriole. CO, either endogenous or exogenous, inhibits TGF at least in part via cGMP. We hypothesize that CO in the MD, acting via both cGMP-dependent and -independent mechanisms, attenuates TGF by acting downstream from depolarization and calcium entry into the MD cells. In vitro, microdissected rabbit afferent arterioles and their MD were simultaneously perfused and TGF was measured as the decrease in afferent arteriole diameter. MD depolarization was induced with ionophores, while adding the CO-releasing molecule-3 to the MD perfusate at nontoxic concentrations. CO-releasing molecule-3 blunted depolarization-induced TGF at 50 &mgr;mol/L, from 3.6±0.4 to 2.5±0.4 µm (P<0.01), and abolished it at 100 &mgr;mol/L, to 0.1±0.1 &mgr;m (P<0.001; n=6). When cGMP generation was blocked by guanylyl cyclase inhibitor LY83583 added to the MD, CO-releasing molecule-3 no longer affected depolarization-induced TGF at 50 &mgr;mol/L (2.9±0.4 versus 3.0±0.4 µm) but partially inhibited TGF at 100 &mgr;mol/L (to 1.3±0.2 &mgr;m; P<0.05; n=9). Experiments using eicosatetraynoic acid and indomethacin suggest arachidonic acid metabolites do not mediate the cGMP-independent effect of CO. We then added the calcium ionophore A23187 to the MD, which caused TGF (4.1±0.6 &mgr;mol/L); A23187-induced TGF was inhibited by CO-releasing molecule-3 at 50 &mgr;mol/L (1.9±0.6 &mgr;mol/L; P<0.01) and 100 &mgr;mol/L (0.2±0.5 &mgr;mol/L; P<0.001; n=6). We conclude that CO inhibits TGF acting downstream from depolarization and calcium entry, acting via cGMP at low concentrations, but additional mechanisms of action may be involved at higher concentrations.
Multi-View Object Retrieval via Multi-Scale Topic Models

The increasing number of 3D objects in various applications has increased the requirement for effective and efficient 3D object retrieval methods, which attracted extensive research efforts in recent years. Existing works mainly focus on how to extract features and conduct object matching. With the increasing applications, 3D objects come from different areas. In such circumstances, how to conduct object retrieval becomes more important. To address this issue, we propose a multi-view object retrieval method using multi-scale topic models in this paper. In our method, multiple views are first extracted from each object, and then the dense visual features are extracted to represent each view. To represent the 3D object, multi-scale topic models are employed to extract the hidden relationship among these features with respect to varied topic numbers in the topic model. In this way, each object can be represented by a set of bag of topics. To compare the objects, we first conduct topic clustering for the basic topics from two data sets, and then generate the common topic dictionary for new representation. Then, the two objects can be aligned to the same common feature space for comparison. To evaluate the performance of the proposed method, experiments are conducted on two data sets. The 3D object retrieval experimental results and comparison with existing methods demonstrate the effectiveness of the proposed method.
Cholesterol Depletion Disorganizes Oocyte Membrane Rafts Altering Mouse Fertilization

Drastic membrane reorganization occurs when mammalian sperm binds to and fuses with the oocyte membrane. Two oocyte protein families are essential for fertilization, tetraspanins and glycosylphosphatidylinositol-anchored proteins. The firsts are associated to tetraspanin-enriched microdomains and the seconds to lipid rafts. Here we report membrane raft involvement in mouse fertilization assessed by cholesterol modulation using methyl-β-cyclodextrin. Cholesterol removal induced: (1) a decrease of the fertilization rate and index; and (2) a delay in the extrusion of the second polar body. Cholesterol repletion recovered the fertilization ability of cholesterol-depleted oocytes, indicating reversibility of these effects. In vivo time-lapse analyses using fluorescent cholesterol permitted to identify the time-point at which the probe is mainly located at the plasma membrane enabling the estimation of the extent of the cholesterol depletion. We confirmed that the mouse oocyte is rich in rafts according to the presence of the raft marker lipid, ganglioside GM1 on the membrane of living oocytes and we identified the coexistence of two types of microdomains, planar rafts and caveolae-like structures, by terms of two differential rafts markers, flotillin-2 and caveolin-1, respectively. Moreover, this is the first report that shows characteristic caveolae-like invaginations in the mouse oocyte identified by electron microscopy. Raft disruption by cholesterol depletion disturbed the subcellular localization of the signal molecule c-Src and the inhibition of Src kinase proteins prevented second polar body extrusion, consistent with a role of Src-related kinases in fertilization via signaling complexes. Our data highlight the functional importance of intact membrane rafts for mouse fertilization and its dependence on cholesterol.
Ultra High Energy Neutrino Signature in Top-Down Scenario

Neutrinos are the best candidates to test the extreme Universe and ideas beyond the Standard Model of particle Physics. Once produced, neutrinos do not suffer any kind of attenuation by intervening radiation fields like the Cosmic Microwave Background and are not affected by magnetic fields. In this sense neutrinos are useful messengers from the far and young Universe. In the present paper we will discuss a particular class of sources of Ultra High Energy Cosmic Rays introduced to explain the possible excess of events with energy larger than the Graisen-Zatsepin-Kuzmin cut-off. These sources, collectively called top-down, share a common feature: UHE particles are produced in the decay or annihilation of superheavy, exotic, particles. As we will review in the present paper, the largest fraction of Ultra High Energy particles produced in the top-down scenario are neutrinos. The study of these radiation offers us a unique opportunity to test the exotic mechanisms of the top-down scenario.
Corporate Asset Purchases and Sales: Theory and Evidence

Purchases and sales of operating assets by firms generated $162 billion for shareholders over the past 20 years. This contrasts sharply with the evidence on mergers. This paper characterizes the behavior of value-maximizing firms, which may grow organically, purchase existing assets or sell assets. The approach yields an endogenous selection model that links asset purchases and sales to fundamental properties of the firm. Empirical tests confirm the predictions of the model. In particular, return on assets and size strongly predict when firms purchase or sell assets, and the transaction size covaries with the value of capital employed by the firm. These findings indicate that corporate asset purchases and sales are consistent with efficient investment decisions.
The old metal-poor open cluster ESO 92-SC05 : accreted from a dwarf galaxy?

The study of old open clusters outside the solar circle can bring constraints on formation scenarios of the outer disc. In particular, accretion of dwarf galaxies has been proposed as a likely mechanism in the area. We use BVI photometry for determining fundamental parameters of the faint open cluster ESO 92-SC05. Colour–magnitude diagrams are compared with Padova isochrones, in order to derive age, reddening and distance. We derive a reddening E(B − V) = 0.17, and an old age of ∼6.0 Gyr. It is one of the rare open clusters known to be older than 5 Gyr. A metallicity of Z ∼ 0.004 or [M/H] ∼− 0.7 is found. The rather low metallicity suggests that this cluster might be the result of an accretion episode of a dwarf galaxy.
A Leaderless mRNA Can Bind to Mammalian 80S Ribosomes and Direct Polypeptide Synthesis in the Absence of Translation Initiation Factors

ABSTRACT Translation initiation in eukaryotic cells is known to be a complex multistep process which involves numerous protein factors. Here we demonstrate that leaderless mRNAs with initiator Met-tRNA can bind directly to 80S mammalian ribosomes in the absence of initiation factors and that the complexes thus formed are fully competent for the subsequent steps of polypeptide synthesis. We show that the canonical 48S pathway of eukaryotic translation initiation has no obvious advantage over the 80S pathway of translation initiation on leaderless mRNAs and suggest that, in the presence of competing mRNAs containing a leader, the latter mechanism will be preferred. The direct binding of the leaderless mRNA to the 80S ribosome was precluded when such an mRNA was supplied with a 5′ leader, irrespective of whether it was in a totally single-stranded conformation or was prone to base pairing. The striking similarity between the mechanisms of binding of leaderless mRNAs with mammalian 80S or bacterial 70S ribosomes gives support to the idea that the alternative mode of translation initiation used by leaderless mRNAs represents a relic from early steps in the evolution of the translation apparatus.