Miracle-dz/UniFAR-FTUs huggingface dataset:
Mode of addition of x-ray doses given with different oxygen concentrations.

Roots of the broad bean (vicia faba) have been given an X-ray dose D1 while in an oxygen concentration C1, and ten minutes later a second dose D2 in a changed concentration C2. The effect on the growth made in the next ten days depends only on the total F1D1 + F2D2, where F1 and F2 are factors characteristic of the oxygen concentrations alone.
Modularity in Artificial Neural Networks

The concept of modularity is a main concern for the generation of artificially intelligent systems. Modularity is an ubiquitous organization principle found everywhere in natural and artificial complex systems (Callebaut, 2005). Evidences from biological and philosophical points of view (Caelli and Wen, 1999) (Fodor, 1983), indicate that modularity is a requisite for complex intelligent behaviour. Besides, from an engineering point of view, modularity seems to be the only way for the construction of complex structures. Hence, whether complex neural programs for complex agents are desired, modularity is required. This article introduces the concepts of modularity and module from a computational point of view, and how they apply to the generation of neural programs based on modules. Two levels, strategic and tactical, at which modularity can be implemented, are identified. How they work and how they can be combined for the generation of a completely modular controller for a neural network based agent is presented.
Performance evaluation of thread prefetching for recursive data structures

The memory wall problem is one of the important issues in modern computer system — it affects the system performance in spite of the powerful processor. The emergence of multi-core processors has further exacerbated the problem. On the other hand, the increasing use of the linked data structure in applications aggravates the memory access latency. This paper dispatches two thread prefetching techniques based on CMP which prefetches the demanded data into the shared cache in advance to hide the long memory access latency, and evaluates these two helper thread prefetching algorithms based on three fundamental aspects of data prefetching. The performance evaluation of thread prefetching shows with acceptable coverage, increasing timeliness and accuracy can improve performance of threaded prefetching. However, improving accuracy by issuing prefetches earlier introduces more uncertainty in the prefetching, hence reducing coverage. Performance results of four benchmark applications when applying with two thread prefetching techniques is also provided.
Complications of chemoport in children with cancer: Experience of 54,100 catheter days from a tertiary cancer center of Southern India

Abstract Background: Chemoport is an essential part of the management of children with cancer and provides long-term venous access. There are few studies from resource poor countries reporting complications of chemoport. Aims: This study was aimed at describing the complications of chemoport in patients with cancer. Materials and Methods: This retrospective observational study analyzed 200 patients <15 years of age who underwent chemoport insertion. The medical records of these patients were reviewed for the patient characteristics, diagnosis, nature of port use, port-related complications and their management. Results: A total of 209 ports were implanted in 200 patients and 24 ports were removed due to port-related complications. There were 122 boys and 78 girls whose ages ranged from 4 months to 13 years (median age 2.5 years). About72% of patients were <2 years old. The cumulative duration of catheterization was 54,100 days. Of 209 ports, there were 36 complications that led to the removal of 21 ports. Port-related infection was the most common infection observed in our study (0.66/1000 catheter days and 11.9%). Mechanical complications were seen in 9 patients. Venous thrombosis and skin necrosis occurred in one patient each. Conclusions: Use of chemoport is safe and is a boon for children with cancer in developing countries with incidence of complications similar to Western countries. Although use of chemoport is associated with complications, they are easily managed. With stringent catheter care by trained personnel, some complications can be prevented.
Advection of methane in the hydrate zone: model, analysis and examples

A two‐phase two‐component model is formulated for the advective–diffusive transport of methane in liquid phase through sediment with the accompanying formation and dissolution of methane hydrate. This free‐boundary problem has a unique generalized solution in L1; the proof combines analysis of the stationary semilinear elliptic Dirichlet problem with the nonlinear semigroup theory in Banach space for an m‐accretive multi‐valued operator. Additional estimates of maximum principle type are obtained, and these permit appropriate maximal extensions of the phase‐change relations. An example with pure advection indicates the limitations of these estimates and of the model developed here. We also consider and analyze the coupled pressure equation that determines the advective flux in the transport model. Copyright © 2015 John Wiley & Sons, Ltd.
The Legal Profession as Gatekeeper to the Judiciary: Design Faults in Measures to Enhance Diversity

The gate-keeping role played by the legal profession in the judicial appointments process gives rise to the translation of entrenched group-based identity hierarchies from legal practice into the judiciary. The relationship between the composition of the legal profession and the judiciary has been almost completely unaffected by recent reforms designed to increase diversity in the composition of the judiciary. This article identifies legal and institutional defects which help to explain the failure to disrupt the reproduction of these patterns of appointment. We identify two particular defects which we call soft target radicalism and regulatory bind as important factors inhibiting change. We conclude that if the legal profession is to retain its gate-keeping role, equality law which directly regulates legal practice should be strengthened and the regulatory binds in which the Judicial Appointments Commission and other public entities are caught should be loosened.
Accumulation of protein O‐GlcNAc modification inhibits proteasomes in the brain and coincides with neuronal apoptosis in brain areas with high O‐GlcNAc metabolism

All tissues contain the enzymes that modify and remove O‐GlcNAc dynamically from nucleocytoplasmic proteins. These enzymes have been shown to play a role in the control of transcription, vesicular trafficking and, more recently, proteasome function. Modification by O‐GlcNAc of the 19S cap of the proteasome inhibits proteasomal function. Transcripts of both O‐GlcNAc transferase and O‐GlcNAcase are very abundant in the brain, with the highest concentrations in hippocampal neurons and Purkinje cells. When the on‐rate of modification is favored over the off‐rate by intraventricular administration of a drug, streptozocin, these areas of the brain display the most rapid accumulation of O‐GlcNAc. Cerebral proteasome function is reduced and ubiquitin and p53 accumulate in these brain regions, with the subsequent activation of a p53‐dependent transgene and the endogenous Mdm2 gene. Later, some hippocampal cells, but not Purkinje cells, undergo apoptosis. These observations suggest that the O‐GlcNAc system may participate in neurodegeneration, particularly in the hippocampus.
“Media Time = Family Time”

Media use in families has generally been examined from a narrow viewpoint, focusing on monitoring or co-viewing. The current research provides an expanded view of positive media use in families with adolescents by examining associations between diverse positive media use and family and adolescents outcomes. In addition, we used qualitative methods to provide a more comprehensive view of how families use media in positive ways, specifically drawing distinctions between traditional entertainment media and social media. Participants included 633 adolescents and their parents who completed a range of quantitative and qualitative measures on media use and adolescent and family outcomes. Results revealed that positive media use was positively associated with general family functioning (for girls), parental involvement (for both boys and girls), and adolescent disclosure to parents (for boys). Qualitative results revealed that families use media in diverse ways including for entertainment, emotional connection, discussion, information, and documentation. Results are discussed within the broad framework of family systems theory.
Role of lime in the generation of reactive oxygen species from betel-quid ingredients.

The role of lime in the formation of reactive oxygen species (ROS), i.e., O2-. , H2O2, and OH. , from betel-quid components (extracts of areca nut and catechu) was investigated in vitro using a chemiluminescence technique and an assay for oxidative DNA damage involving analysis of 8-hydroxy-2'-deoxyguanosine. Of the various areca-nut extracts, the catechin fraction, at alkaline pH, was shown to be the most active producer of ROS. The free Ca(OH)2 content and pH of lime samples (a component of betel quid and chewing tobacco) were highly correlated with the generation of ROS from areca-nut extract in vitro and with oxidative base damage to DNA in vitro. While Fe2+ had an enhancing effect on ROS formation, Mg2+ had a marked inhibitory effect. The cytogenetic effects of ROS generated in vivo were measured in Syrian golden hamsters in which the cheek pouch had been painted with lime and an areca-nut extract or catechu, singly or in combination. The frequency of micronucleated cells was increased only in animals that had received both the areca-nut extract and lime. The frequency of micronucleated cells in exfoliated oral mucosal cells from Indian chewers of betel quid with tobacco containing lime or of tobacco with lime was significantly higher than in a control (no habit) group. These studies demonstrate that addition of lime to betel quid constituents generates ROS, which induce cytogenetic damage in hamster cheek pouch and may contribute to the cytogenetic damage observed in the oral cavity of betel-quid chewers. These results implicate ROS in clastogenesis and probably in the etiology of oral cancer.
Acts that matter - an analysis of Kiva

Purpose – The goal of this paper is to provide insight into how global social responsibility is performed through economic, mental and even physical investment and engagement by consumers and organisations. Design/methodology/approach – An illustrative analysis from the corporate website and blogs of an ethical organisation is undertaken. The analytical approach is communicative and inspired by discourse and legitimation studies and more particularly based on the framework of legitimation in discourse and communication developed by Theo van Leeuwen. Findings – The paper claims that new forms of value creation and a new relational logic of ethics – a so-called “logic of matter” – are emerging. From the three types of relational logic of matter ethics – an ethics of care, an ethics of reversibility and an ethics of activism – the ethics of activism plays the most important role in our material. Research limitations/implications – The analytical examples presented in this paper demonstrate how the new relati.
It's the Thought that Counts

Agnes's brakes fail. Should she continue straight into the busy intersection or should she swerve into the field? Add to the story, what Agnes does not and cannot know, that continuing into the intersection will cause no harm, whereas swerving into the apparently empty field will cause a death. I evaluate arguments for the claim that she should enter the intersection, i.e. for objectivism about right and wrong; and arguments for the claim that she should swerve, i.e. for subjectivism about right and wrong, and conclude that subjectivism is more plausible. I also consider the view that ‘ought’ and ‘wrong’ are systematically ambiguous, that she subjectively ought to swerve and that she objectively ought to enter the intersection. I argue that most versions of this suggestion are unworkable, and that even the best version is less plausible than pure subjectivism.
Phosphorylation of the Oncofetal Variant of the Human Bile Salt-dependent Lipase

In this paper, we report, for the first time, the localization of the phosphorylation site of the fetoacinar pancreatic protein (FAPP), which is an oncofetal variant of the pancreatic bile salt-dependent lipase. Using Chinese hamster ovary (CHO) cells transfected with the cDNA encoding FAPP, we radiolabeled the enzyme with 32P, and then the protein was purified by affinity chromatography on cholate-immobilized Sepharose column and submitted to a CNBr hydrolysis. Analysis of peptides by high pressure liquid chromatography, associated with the radioactivity profile, revealed that the phosphorylation site is located at threonine 340. Site-specific mutagenesis experiments, in which the threonine was replaced by an alanine residue, were used to invalidate the phosphorylation of FAPP and to study the influence of the modification on the activity and secretion of the enzyme. These studies showed that CHO cells, transfected with the mutated cDNA of FAPP, kept all of their ability to synthesize the protein, but the loss of the phosphorylation motif prevented the release of the protein in the extracellular compartment. However, the mutated enzyme, which was sequestrated in the transfected CHO cells, remains active on bile salt-dependent lipase substrates.
The Self : From Soul to Brain

The Mount Sinai School of Medicine is an imposing monument to the wealth and power of scientific medicine. Set on its own block in upper Manhattan, its rhetorical centre is the Stern Auditorium. Here, just over a year after 9/11, a group of gurus and self-seekers assembled to confer on the nature of the self. I was there too, looking for help in constructing a grand unified theory of soul and brain.
Is Loss of Fixation Following Locked Plating of Proximal Humeral Fractures Related to the Number of Screws and Their Positions in the Humeral Head?

The aim of the study was to examine the correlation between the chosen position of screws and the complications observed in patients who underwent locked plating of proximal humeral fractures. We evaluated radiographs of 367 patients treated by locked-plating for proximal humeral fractures. Radiographs were taken at one day, 6 weeks, 3 months and 6 months after surgery, and were analyzed for secondary fracture displacement, loss of fixation, cutting out of screws and necrosis of the humeral head. Secondary loss of fixation occurred in 58 cases (15.8%) and among those cutting out of screws was observed in 25 cases (6.8%). In cases of secondary loss of fixation a mean of 6.7 screws were used to fix the fracture (vs 6.6, P=0.425). There was neither significant correlation between position of screws and the occurrence of postoperative loss of fixation in Spearman correlation nor relationship from backward logistic regression analysis. Loss of fixation following locked plating of proximal humeral fractures does not relate to the number of screws and their positions in the humeral head. In consequence, anatomic fracture reduction and restoration of the humeral head-shaft angle are still important factors and should not be disregarded.
Career Counseling Research and Hispanics

This article presents an extensive review of the research literature related to career counseling with Hispanics in the U.S. from 1970 to the present. Most of the research reviewed dealt with Mexican-Americans, and only a few studies included Puerto Ricans in their sample. The article is organized into four areas: occupational aspirations, vocational interests, on-the-job behavior; and educational attainment. It was found that Hispanic students tend to have high occupational and educational aspirations, Holland 's hexagonal model of career interests seem to apply to Hispanics, middle-class and college-educated Hispanics and Anglos are similar in terms of work values and career progression behaviors, and educational attainment among Hispanics varies according to their national origin, generational status, and social class. It was concluded that, in general, the career counseling research related to Hispanics is very limited in terms of content, and for the most part lacks a theoretical base. The findings of this research strongly suggest that the lack of occupational mobility among Hispanics is related to structural factors, such as socioeconomic status and lack of opportunities, and not to cultural characteristics. The literature reviewed also shows that Hispanics are not a homogeneous group and that there are important differences between the various Hispanic subgroups as well as between Hispanics from different socioeconomic backgrounds. Suggestions for future research are offered and methodological issues in career counseling research with Hispanics are examined.
Dodeca-CLE Peptides as Suppressors of Plant Stem Cell Differentiation

In plants and animals, small peptide ligands that signal in cell-cell communication have been suggested to be a crucial component of development. A bioassay of single-cell transdifferentation demonstrates that a dodecapeptide with two hydroxyproline residues is the functional product of genes from the CLE family, which includes CLAVATA3 in Arabidopsis. The dodecapeptide suppresses xylem cell development at a concentration of 10–11 M and promotes cell division. An application, corresponding to all 26 Arabidopsis CLE protein family members, of synthetic dodecapeptides reveals two counteracting signaling pathways involved in stem cell fate.
Organizational Autonomy and Professional Norms in Science: A Case Study of the Lawrence Livermore Laboratory

Functionalist theories in the sociology of science suggest that applied research organizations, insofar as they violate professional norms of research autonomy, professional recognition and open communication, also violate the epistemological and methodological requirements of successful research. The analysis presented here, based on interviews with scientists at a major US nuclear weapons laboratory (the Lawrence Livermore Laboratory), suggests that research norms and criteria of success are both situationally defined. Recent models of formal organizations are used to describe two levels at which professional norms are coopted to achieve organizational research goals: the first level is the internal structure of the organization, and the second, environmental, level consists of professional and peer relations of Livermore scientists and the laboratory's relations to the state. The conclusions suggest some structural limitations of this alternative model of science.
Four Novel p.N385K, p.V36A, c.1033–1034insT and c.1417–1418delCT Mutations in the Sphingomyelin Phosphodiesterase 1 (SMPD1) Gene in Patients with Types A and B Niemann-Pick Disease (NPD)

Background: Types A and B Niemann-Pick disease (NPD) are autosomal-recessive lysosomal storage disorders caused by the deficient activity of acid sphingomyelinase due to mutations in the sphingomyelin phosphodiesterase 1 (SMPD1) gene. Methods: In order to determine the prevalence and distribution of SMPD1 gene mutations, the genomic DNA of 15 unrelated Iranian patients with types A and B NPD was examined using PCR, DNA sequencing and bioinformatics analysis. Results: Of 8 patients with the p.G508R mutation, 5 patients were homozygous, while the other 3 were heterozygous. One patient was heterozygous for both the p.N385K and p.G508R mutations. Another patient was heterozygous for both the p.A487V and p.G508R mutations. Two patients (one homozygous and one heterozygous) showed the p.V36A mutation. One patient was homozygous for the c.1033–1034insT mutation. One patient was homozygous for the c.573delT mutation, and 1 patient was homozygous for the c.1417–1418delCT mutation. Additionally, bioinformatics analysis indicated that two new p.V36A and p.N385K mutations decreased the acid sphingomyelinase (ASM) protein stability, which might be evidence to suggest the pathogenicity of these mutations. Conclusion: with detection of these new mutations, the genotypic spectrum of types A and B NPD is extended, facilitating the definition of disease-related mutations. However, more research is essential to confirm the pathogenic effect of these mutations.
Pathophysiological actions of neuropathy‐related anti‐ganglioside antibodies at the neuromuscular junction

The outer leaflet of neuronal membranes is highly enriched in gangliosides. Therefore, specific neuronal roles have been attributed to this family of sialylated glycosphingolipids, e.g. in modulation of ion channels and transporters, neuronal interaction and recognition, temperature adaptation, Ca2+ homeostasis, axonal growth, (para)node of Ranvier stability and synaptic transmission. Recent developmental, ageing and injury studies on transgenic mice lacking subsets of gangliosides indicate that gangliosides are involved in maintenance rather than development of the nervous system and that ganglioside family members are able to act in a mutually compensatory manner. Besides having physiological functions, gangliosides are the likely antigenic targets of autoantibodies present in Guillain‐Barré syndrome (GBS), a group of neuropathies with clinical symptoms of motor‐ and/or sensory peripheral nerve dysfunction. Antibody binding to peripheral nerves is thought to either interfere with ganglioside function or activate complement, causing axonal damage and thereby disturbed action potential conduction. The presynaptic motor nerve terminal at the neuromuscular junction (NMJ) may be a prominent target because it is highly enriched in gangliosides and lies outside the blood–nerve barrier, allowing antibody access. The ensuing neuromuscular synaptopathy might contribute to the muscle weakness in GBS patients. Several groups, including our own, have studied the effects of anti‐ganglioside antibodies in ex vivo and in vivo experimental settings at mouse NMJs. Here, after providing a background overview on ganglioside synthesis, localization and physiology, we will review those studies, which clearly show that anti‐ganglioside antibodies are capable of binding to NMJs and thereby can exert a variety of pathophysiological effects. Furthermore, we will discuss the human clinical electrophysiological and histological evidence produced so far of the existence of a neuromuscular synaptopathy contributing to muscle weakness in GBS patients.
Inactivation of Cryptosporidium parvum Oocysts by Ammonia

The survival of Cryptosporidium parvum oocysts in soil and water microhabitats may be affected by the environmental production and release of free ammonia. The objective of this study was to determine the effects of increasing free ammonia concentrations and times of exposure on oocyst viability. Wild-type oocysts were obtained from naturally infected calf feces by chemical (continuous-flow) centrifugation and sucrose gradients. Ammonia (NH(3)) from a commercial solution was applied in concentrations ranging from 0.007 to 0.148 M. Exposure times ranged from 10 min to 24 h at a constant temperature of 24 +/- 1 degrees C. Viability of oocysts was determined with a dye permeability assay and an in vitro excystation assay (M. B. Jenkins, L. J. Anguish, D. D. Bowman, M. J. Walker, and W. C. Ghiorse, Appl. Environ. Microbiol. 63:3844-3850, 1997). Even the lowest concentration of ammonia decreased significantly the viability of oocysts after 24 h of exposure. Increasing concentrations of ammonia increased inactivation rates, which ranged from 0.014 to 0.066 h. At the highest concentration of ammonia, a small fraction of viable oocysts still remained. Exposure to pH levels corresponding to those associated with the ammonia concentrations showed minimal effects of alkaline pH alone on oocyst viability. This study shows that environmentally relevant concentrations of free ammonia may significantly increase the inactivation of oocysts in ammonia-containing environments.