Miracle-dz/UniFAR-FTUs huggingface dataset:
A review of spatial reasoning and interaction for real-world robotics

Truly universal helper robots capable of coping with unknown, unstructured environments must be capable of spatial reasoning, i.e. establishing geometric relations between objects and locations, expressing those in terms understandable by humans. It is therefore desirable that spatial and semantic environment representations are tightly interlinked. 3D robotic mapping and the generation of consistent metric representations of space are highly useful for navigation and exploration, but they do not capture symbol-level information about the environment. This is, however, essential for reasoning, and enables interaction via natural language, which is arguably the most common and natural communication channel used and understood by humans. This article presents a review of research in three major fields relevant for this discussion of spatial reasoning and interaction. Firstly, dialogue systems are an integral part of modern approaches to situated human–robot interaction. Secondly, interactive robots must be equipped with environment representations and reasoning methods that are suitable for both navigation and task fulfillment, as well as for interaction with human partners. Thirdly, at the interface between these domains are systems that ground language in systemic environment representation and which allow the integration of information from natural language descriptions into robotic maps. For each of these areas, important approaches are outlined and relations between the fields are highlighted, and challenging applications as well as open problems are discussed.
Local Optima Networks of the Permutation Flowshop Scheduling Problem: Makespan vs. total flow time

Local Optima Networks were proposed to understand the structure of combinatorial landscapes at a coarse-grained level. We consider a compressed variant of such networks with features that are meaningful for the study of search difficulty in the context of local search. In particular, we investigate different landscapes of the Permutation Flowshop Scheduling Problem. The insert and 2-exchange neighbourhoods are considered, and two different objective functions are taken into account: the makespan and the total flow time. The aim is to analyse the network features in order to find differences between the landscape structures, giving insights about which features impact algorithm performance. We evaluate the correlation between landscape properties and the performance of an Iterated Local Search algorithm. Visualisation of the network structure is also given, where evident differences between the makespan and total flow time are observed.
Predominant extrahepatic biliary disease in autosomal recessive polycystic kidney disease: A new association

Abstract: Autosomal recessive polycystic kidney disease (ARPKD) is characterized by dilation of ectatic renal collecting ducts, intrahepatic biliary dysgenesis, and portal fibrosis. Portal hypertension and recurrent bacterial cholangitis can dominate the clinical picture in long‐term survivors. Predominant extrahepatic bile duct disease was revealed in four patients who underwent magnetic resonance cholangiopancreatography. All four patients had portal hypertension, although liver biochemistries did not suggest biliary disease. In two of the patients, cholangitis was clinically ascribed to the bile duct disease. Western blot analysis of plasma membranes from normal rat extrahepatic bile duct and kidney revealed the presence of polyductin as a single ∼440 kDa protein. Although the exact function of polyductin in the extrahepatic duct is unknown, it may have a role in the development and control of lumenal size. Clinical management of patients with ARPKD should include consideration of potential problems related to extrahepatic bile duct disease.
Book Reviews

Máire Messenger Davies’ recently published volume entitled Children, Media and Culture is an ambitious and quite helpful synthesis of scholarly research, policy reports, professional opinion and personal impressions on what it has meant to be represented as a child in relation to different cultural and historical contexts and media forms up to the present day. Davies trains a critical lens on such diverse topics as the Child Study Movement of the nineteenth century, representations of children in Renaissance and Gilded Age painting, theoretical understandings of children’s intellectual development, the Harry Potter phenomenon, and the risks associated with social networking and other new media communication practices among children and youth. A principal, stated aim of the book, the author writes, is to argue that “the terms ‘culture’ and ‘children’ are always intrinsically linked” and that “one of the primary ways in which they are linked is through media” (p. 15). According to her online faculty profile, Dr Davies, currently Emerita Professor of Media Studies at the University of Ulster in Northern Ireland, has had an especially varied professional life, including a career as a journalist and degrees in English Literature and Psychology. This interdisciplinary experience, it would seem, has prepared Professor Davies to achieve in this book no mean feat: a conceptual and practical reconciliation of these three core themes of “children”, “media” and “culture”. The explanations for these, as Davies herself admits, are unavoidably complex and controversial and “[draw] on academic and scholarly traditions which are very diverse and not always on good terms with each other” (p. 5). I would say that this author has done a very successful job of repairing disciplinary rifts, to her readers’ benefit. While this book certainly does advance a cogent, coherent argument, as above, I think its greatest strength is in the diverse collection of resources and insights that it brings together towards cultivating in its readers a deeper, broader understanding of interrelationships between children, media and culture. My one significant criticism of the book, explained below, is that it engages only tangentially and fairly superficially with cultural institutions and practices of education, which loom so large in the childhood experiences of so many. Nonetheless, I can highly recommend this book to students and scholars alike, within any field, who have an interest in the culturally and textually mediated experience of childhood and want to survey the depth and breadth of associated issues. This book is organized into two parts. Part 1 is entitled “The Study of Childhood” and is intended to examine “some of the ways in which children and childhood have been defined and studied by scholars from different disciplines”, which include “the non-media ones of medicine (pediatrics, public health), history, psychology, sociology and political economy, as well as media and cultural studies” (p. 7). The objects of Chapter 1, “Defining
Treatment of a large radicular cyst-enucleation or decompression?

INTRODUCTION Radicular cysts treatment involves surgical approach, more or less aggressive. However, treatment of large cystic lesions, including radicular cysts, causes some of dilemmas concerning the choice of the surgical method, especially the degree of radicalism. CASE REPORT We presented a 65-year-old male patient with large radicular cyst in the mandible. A large elliptical multilocular radiolucency, located in the left side of the mandible, being in close vicinity to the mandibular canal, was registered at the orthopantomographic radiography. There was a risk of pathological fracture of the mandible. However, the cyst was completely removed by enucleation without intraoperative and postoperative complications. CONCLUSION The presented case support the opinion that careful enucleation of large mandibular cysts may be done without complications, such as damages of surrounding anatomical structures or mandibular fracture. The authors indicate reasons for strong support of the undertaken surgical approach of treating large radicular cysts in the mandible.
Personalized LBSN Recommendation System

To explore deep value of user comments in LBSN, this article through to Foursquare check-in with geography information analysis and review data using AFINN dictionary user comments emotions tend to get user implicit rating for this product. Using the score as the foundation, proposed and implemented an integrated collaborative filtering recommendation algorithm based on user modeling based on geographic location, recommended results for users such as user friend recommended recommend he might be interested in. Finally, the system performed well in MAE measurement and solve the data sparse problem.
The Cell Cycle Inhibitor p16INK4A Sensitizes Lymphoblastic Leukemia Cells to Apoptosis by Physiologic Glucocorticoid Levels*

The cyclin-dependent kinase inhibitor p16INK4A is frequently inactivated in childhood T-cell acute lymphoblastic leukemia. To investigate possible consequences of this genetic alteration for tumor development, we conditionally expressed p16INK4A in the T-cell acute lymphoblastic leukemia line CCRF-CEM, which carries a homozygous deletion of this gene. In agreement with its reported function, p16INK4A expression was associated with hypophosphorylation of the retinoblastoma protein pRB and stable cell cycle arrest in G0/G1, documenting that the pRB/E2F pathway is functional in these cells. Unexpectedly, p16INK4Aexpression increased the sensitivity threshold for glucocorticoid (GC)-induced apoptosis from therapeutic to physiologic levels. As a possible explanation for this phenomenon, we found that p16INK4A-arrested cells had elevated GC receptor expression associated with enhanced GC-mediated transcriptional activity and increased responsiveness of the GC-regulated cyclin D3 gene. These data are supported by our previous findings that GC receptor levels critically influence GC sensitivity and imply that p16INK4Ainactivation, in addition to allowing unrestricted proliferation, represents a mechanism by which lymphoid tumor cells might escape cell death triggered by endogenous GC.
Colorectal cancer cells suppress CD4+ T cells immunity through canonical Wnt signaling

Understanding how colorectal cancer escapes from immunosurveillance and immune attack is important for developing novel immunotherapies for colorectal cancer. In this study we evaluated the role of canonical Wnt signaling in the regulation of T cell function in a mouse colorectal cancer model. We found that colorectal cancer cells expressed abundant Wnt ligands, and intratumoral T cells expressed various Frizzled proteins. Meanwhile, both active β-catenin and total β-catenin were elevated in intratumoral T cells. In vitro study indicated that colorectal cancer cells suppressed IFN-γ expression and increased IL-17a expression in activated CD4+ T cells. However, the cytotoxic activity of CD8+ T cells was not altered by colorectal cancer cells. To further evaluate the importance of Wnt signaling for CD4+ T cell-mediated cancer immunity, β-catenin expression was enforced in CD4+ T cells using lentiviral transduction. In an adoptive transfer model, enforced expression of β-catenin in intratumoral CD4+ T cells increased IL-17a expression, enhanced proliferation and inhibited apoptosis of colorectal cancer cells. Taken together, our study disclosed a new mechanism by which colorectal cancer impairs T cell immunity.
Whole Genome Sequencing Identifies a Deletion in Protein Phosphatase 2A That Affects Its Stability and Localization in Chlamydomonas reinhardtii

Whole genome sequencing is a powerful tool in the discovery of single nucleotide polymorphisms (SNPs) and small insertions/deletions (indels) among mutant strains, which simplifies forward genetics approaches. However, identification of the causative mutation among a large number of non-causative SNPs in a mutant strain remains a big challenge. In the unicellular biflagellate green alga Chlamydomonas reinhardtii, we generated a SNP/indel library that contains over 2 million polymorphisms from four wild-type strains, one highly polymorphic strain that is frequently used in meiotic mapping, ten mutant strains that have flagellar assembly or motility defects, and one mutant strain, imp3, which has a mating defect. A comparison of polymorphisms in the imp3 strain and the other 15 strains allowed us to identify a deletion of the last three amino acids, Y313F314L315, in a protein phosphatase 2A catalytic subunit (PP2A3) in the imp3 strain. Introduction of a wild-type HA-tagged PP2A3 rescues the mutant phenotype, but mutant HA-PP2A3 at Y313 or L315 fail to rescue. Our immunoprecipitation results indicate that the Y313, L315, or YFLΔ mutations do not affect the binding of PP2A3 to the scaffold subunit, PP2A-2r. In contrast, the Y313, L315, or YFLΔ mutations affect both the stability and the localization of PP2A3. The PP2A3 protein is less abundant in these mutants and fails to accumulate in the basal body area as observed in transformants with either wild-type HA-PP2A3 or a HA-PP2A3 with a V310T change. The accumulation of HA-PP2A3 in the basal body region disappears in mated dikaryons, which suggests that the localization of PP2A3 may be essential to the mating process. Overall, our results demonstrate that the terminal YFL tail of PP2A3 is important in the regulation on Chlamydomonas mating.
Title : Performance Assessment and Prognostics of A Hybrid System using a Particle Filter approach

One challenge for the industry is to predict the performance degradation of a system based on existing observations and to take predictive maintenance action to prevent faults and failures from occurring. In this paper, a new method for hybrid system’s performance assessment is introduced, which uses Particle Filter. The novel characteristic of this prognostic method is to monitor a certain class of unknown hybrid systems by learning the system inherent behaviors from continuous observations of that system. The system’s normal or abnormal conditions are to be investigated in a discrete state space by recognizing the system’s operational state trajectory. The Rao-Blackwellised Particle Filter is employed to estimate the marginal posterior of the system’s discrete states from prior distribution. This method has been successfully demonstrated on an automatic door control system.
Effect of Aging on AutoAntibodies to Wounded Tissues

Wound healing succeeds tissue destruction. We hypothesized that antibodies might bind to wounded tissues, which would facilitate the engulfment of damaged tissues by macrophages. We detected the autoantibodies in sera of different ages of mice, which bind to wounded tissues. We detected IgG1 binding to wounded tissues by using FITClabeled anti-IgG1 in C57BL/6 mice. These bands were highest in 4 months old C57BL/6 mice. The sera taken from 2 months and 20 months old mice also bound to wounded tissues, although the bands were weaker than those of 4 months old mice. We also examined the autoreactive IgM binding to wounded tissues. We could detect relatively strong bands even in 2 M old mice. The pattern of these bands was changed by advancing age. Intensity of IgM bands was not decreased by advancing age. The splenectomy reduced the intensity of IgG1 bands especially in 4 months old mice. Although we observed the slight delay of wound repair by splenectomy in 2 M and 20 M old mice, we observed that wound repair was strongly delayed in 4 M old mice. Serum from any age of mice enhanced the macrophage phagocytosis by opsonization. Serum taken from splenectomized mice decreased the opsonizing capacity only at 4 M.
Package level interconnect options

Scaling enhances intrinsic transistor performance and degrades interconnects. As the technology steps into nanometer era, global interconnects are becoming bottleneck for overall chip performance. In this paper, we show package level interconnects are an effective alternative for on-chip global wiring. These interconnects behave as LC transmission lines and can be exploited for their near speed of light transmission and low attenuation characteristics. We compare performance - bandwidth, bandwidth density, latency and power consumption - of the package level transmission lines with conventional on-chip global interconnects for different ITRS technology nodes. Based on these results, we show package level interconnects are well suited for power demanding low latency applications and we analyze different interconnect options like memory buses, long inter tile interconnects, clock and power distribution.
Supporting Clinicians in Robot-Assisted Therapy for Autism Spectrum Disorder : Creating and Editing Robot Animations with Full-Body Motion Tracking

Robots show potential to be helpful in therapy for children with autism spectrum disorder. In our experience, clinicians occasionally desire to change the robot behavior to suit the needs of different children. Because clinicians typically lack programming experience, they must currently ask a programmer to program the robots. Robots may be more useful to clinicians if they are able to create and modify actions for the robot. We are designing a user interface based on full-body motion capture to enable clinicians to create and modify animation sequences for robots. Clinicians, computer scientists, and mechanical engineers are collaboratively involved in the design process.
Is innovative behavior really good for the firm?: Innovative work behavior, conflict with coworkers and turnover intention: moderating roles of perceived distributive fairness

Purpose – This study aims to investigate the negative impacts of innovative work behavior (IWB) on conflict with coworkers and turnover intention. It also aims to test the moderating effect of perceived distributive fairness on these relationships.Design/methodology/approach – A total of 460 employees who were working in production and marketing teams at manufacturing and pharmaceutical companies in Indonesia were asked to complete the questionnaire. The final sample consisted of 135 sets of paired data of supervisor and subordinate. The multiple hierarchical regressions were used to test the developed hypotheses.Findings – Findings of this study indicated that innovative work behavior had a positive and significant relationship with conflict with coworkers and turnover intention respectively. Moreover, the findings also found that perceived distributive fairness negatively moderated the relationship between IWB and both conflict with coworkers and turnover intention.Research limitations/implications – Th.
Explaining Income Inequalities in Developing Countries:the Role of Human Capital

This paper investigates the relationship between human capital and economic inequality in the developing countries. The paper analyses an unbalanced panel of 64 countries for the period 1970-2005. The results show that primary, secondary and tertiary level education is negatively associated with inequality (primary being the strongest). Besides, average years of education and government expenditure on education are also found to be inequality reducing, both in the immediate and the medium run. Thus, to give citizens better and more equal opportunities, policy-makers in the developing countries and the development agencies need to give higher importance to primary education. Prenant en consideration le manque de consensus dans la litterature sur le sujet, notre article etudie la relation entre le capital humain et les inegalites economiques, en abordant le cas particulier des pays en developpement ou les inegalites sont flagrantes. Nous analysons un panel non-equilibre constitue de 64 pays pour la periode 1970 a 2005. Les resultats montrent une liaison negative entre l’education primaire, ainsi que secondaire et tertiaire, et les inegalites economiques. Les autres indicateurs du capital humain contribuent egalement a la reduction des inegalites. Donc, afin de reduire les inegalites economiques effectivement pour fournir aux citoyens des opportunites egales, les gouvernements des pays en developpement et la communaute internationale devraient se concentrer sur l’education primaire et superieur.
A 'Different Way': Student Perspectives on International and Cultural Learning

As organisations are becoming increasingly internationalised, the business community is calling for individuals able to solve problems, innovate and collaborate with culturally diverse individuals both locally and internationally. This paper is based upon a small qualitative research study conducted in one Australian university. The study explored the ways students learn about culture and international issues and how they believed such learning could best be fostered through the teaching and learning of business programs. Drawing upon their personal, academic and professional experiences, participants emphasized the need for universities to design programs relevant to their future careers primarily through experiential forms of learning. Students particularly endorsed, international online collaboration, exchange, language development and an appreciation and capacity for the role of soft skills and forming relationships embedded in culturally diverse contexts.
The Rise of Professionalism: A Sociological Analysis

The particular relation that professionalism bears to individualism and to the subjective illusion deserves to be noted. Their special competence empowers professionals and experts to act in situations where laymen feel incompetent or baffled. In fact, the assumption by the public that the expert is competent creates a sort of pragmatic compulsion for the expert: to certify his worth in the eyes of the laity, he must act. Deferentially requested to intervene by his clients, the expert practitioner is compelled to do something; from this point of view, anything is better than nothing. As Freidson remarks: "Indeed, so impressed is he by the perplexity of his clients and by his apparent capacity to deal with those perplexities, that the practitioner comes to consider himself an expert not only in the problems he is trained to deal with but in all human problems. " Most particularly in the personal professions, the behavior of the expert asserts, ideologically, that a variety of ills—and, in particular, those that can most affect the person—have individual remedies. This reinforces the optimistic illusion of ideological individualism: personal problems of all kinds are purely private and admit, as such, individual and ad hoc solutions. In the predominant ideological way of addressing social issues and social relations experienced by individuals, therefore, structural causes, as well as collective action upon those causes, are relegated to a vaguely utopian realm. At the same time, the practitioner9s "compulsion to act" reiterates to the layman that education confers superior powers upon the individual and superior mastery over physical and social environments.
The Effect of Octopamine on the Locust Stomatogastric Nervous System

Octopamine (OA) is a prominent neuromodulator of invertebrate nervous systems, influencing multiple physiological processes. Among its many roles in insects are the initiation and maintenance of various rhythmic behaviors. Here, the neuromodulatory effects of OA on the components of the locust stomatogastric nervous system were studied, and one putative source of OA modulation of the system was identified. Bath application of OA was found to abolish the endogenous rhythmic output of the fully isolated frontal ganglion (FG), while stimulating motor activity of the fully isolated hypocerebral ganglion (HG). OA also induced rhythmic movements in a foregut preparation with intact HG innervation. Complex dose-dependent effects of OA on interconnected FG-HG preparations were seen: 10−5 M OA accelerated the rhythmic activity of both the HG and FG in a synchronized manner, while 10−4 M OA decreased both rhythms. Intracellular stimulation of an identified octopaminergic dorsal unpaired median neuron in the subesophageal ganglion was found to exert a similar effect on the FG motor output as that of OA application. Our findings suggest a mechanism of regulation of insect gut patterns and feeding-related behavior during stress and times of high energy demand.