Miracle-dz/UniFAR-FTUs huggingface dataset:
Avaliação, análise e desenvolvimento de jogo sério digital para desktop sobre sintomas e procedimentos de emergência do Acidente Vascular Cerebral Evaluation, analysis and development of desktop digital serious game on symptoms and emergency procedures of stroke

Na area da Educacao em Saude, os materiais educativos desenvolvidos como cartilhas e videos animados, nem sempre sao muito atrativos e eficazes com o publico mais jovem, como o formado por pre-adolescentes. Diante deste problema buscamos demonstrar que o uso de um jogo serio digital pode facilitar o processo de ensino-aprendizagem de pre-adolescentes acerca dos sintomas e procedimentos de emergencia do Acidente Vascular Cerebral (AVC), partindo da hipotese de que na transmissao de informacoes sobre os sintomas do AVC e do numero do SAMU (Servico Ambulatorio Movel de Urgencia) a utilizacao de um jogo serio digital pode ser mais eficaz no que se refere a preferencia e retencao das informacoes apresentadas do que uma animacao digital desenvolvida com a mesma finalidade e utilizada em campanhas educativas de combate ao AVC. Para tanto o trabalho apresenta uma reflexao sobre o uso de jogos digitais no contexto educacional, aliando os principios de game design com a abordagem do Design Centrado no Usuario para o desenvolvimento de um jogo serio digital para desktop. A metodologia adotada visou a coleta e analise de dados qualitativos e quantitativos, a partir de instrumentos metodologicos adaptados dos ja existentes na literatura (prototipagem de jogo digital, entrevista semiestruturada, escala visual de humor Pick-A-Mood, grupo focal) e desenvolvidos exclusivamente para a pesquisa (teste de retencao com "dedoches" e teste de preferencia), sempre buscando adequa-los aos sujeitos da pesquisa, de modo a poderem ser aplicados de forma rapida e ludica, auxiliando na compreensao e investigacao da experiencia dos pre-adolescentes com os objetos da pesquisa (animacao e jogo serio digital). Concluiu-se que embora nao houve diferencas significativas entre a retencao do numero do SAMU ao comparar o jogo com a animacao, o jogo serio digital demonstrou ser mais eficaz na retencao dos sintomas do AVC e na preferencia dos pre-adolescentes.
The Effects of Hypnosis on Dissociative Identity Disorder: A Reexamination of the Evidence

Objective: To examine the possibility that hypnosis has significant iatrogenic effects on dissociative identity disorder (DID). Method: This paper reexamines previously published data that have been interpreted as indicating that hypnosis does not exert significant iatrogenic effects on DID. Results: The use of hypnosis is associated with differences in DID phenomenology and number of DID patients in treatment. Conclusion: Hypnosis may have significant iatrogenic effects on DID.
Genomics and Genome Sequencing: Benefits for Finfish Aquaculture

The central dogma of molecular biology states that DNA is transcribed to RNA, which is translated into proteins (Crick, 1970), the molecules that facilitate all biological functions. A genome comprises all of an organism’s DNA, or hereditary information. The field of genomics is the study of whole genomes. Genomics has been defined as “a branch of biotechnology concerned with applying the techniques of genetics and molecular biology to the genetic mapping and DNA sequencing of sets of genes or the complete genomes of selected organisms” (Mirriam-Webster Dictionary). Specifically, whereas genetics is the study of a single gene, or a few genes in isolation, genomics examines all of the genes, as well as the non-coding elements (i.e., regions that do not encode proteins or RNA components of the cell), within the DNA of a genome. Although the term genomics was first used in 1987, the field is relatively new and is growing rapidly as new technologies for exploring genomes emerge. The applications of genomics are vast, spanning realms such as medicine, industry and ecology, with implications for global issues including cancer diagnosis, prevention and treatment, alternative energy sources, agriculture, conservation and sustainable development. Furthermore, given that the fundamental basis of genomics DNAis common across all living organisms, genomics stands to bridge the gaps between these fields of study, with synergistic results as multi-disciplinary approaches to answering biological questions are developed.
PSR volume 66 issue 3 Cover and Front matter

century. This essay considers the general nature of historicism and its influence on the recent revolt against positivism in the philosophy of science. Finally, it examines the use that political scientists have made of historicist prin- ciples in opposing positivistic models of political inquiry. It argues that an epistemological relativism becomes unavoidable once certain premises of historicism are embraced. 902 Integration and Instability: Patterns of African Political Development. This paper discusses the construction of a formal model of national political development derived from theories of political integration and instability, and reports the results of tests of the model based on data descriptive of contemporary black African nations. Political integration is conceptually elaborated in terms of processes of horizontal, vertical, and value integration, and political centralization. Political in- stability is conceptualized in terms of elite, communal, and mass instability. These dimensions of integration and instability are operationalized, and the analysis evaluates the hypothesis that inte- gration decreases the likelihood of political instability in African nations, and that political centraliza-tion,
Pharmacology and anti‐addiction effects of the novel κ opioid receptor agonist Mesyl Sal B, a potent and long‐acting analogue of salvinorin A

Acute activation of κ opioid (KOP) receptors results in anticocaine‐like effects, but adverse effects, such as dysphoria, aversion, sedation and depression, limit their clinical development. Salvinorin A, isolated from the plant Salvia divinorum, and its semi‐synthetic analogues have been shown to have potent KOP receptor agonist activity and may induce a unique response with similar anticocaine addiction effects as the classic KOP receptor agonists, but with a different side effect profile.
The Combination of ARIMA with Wavelet De-Noise

The ARIMA model has the ability to extract the useful data from the originate data and the remain is the noise data. But if the originate data has a large amount of noise data, this will has great influence in ARIMA model such as the parameters. In order to eliminate the effect of the noise, this paper combine the ARIMA model with wavelet denoise. First, the originate data is denoise through wavelet transform. Here a reasonable threshold is given according to special method. Then the ARIMA model can be used to work on data analysis. The application result shows that this method can work perfectly.
Knitting and untying the protein network: Modulation of protein ensembles as a therapeutic strategy

Proteins constitute the working machinery and structural support of all organisms. In performing a given function, they must adopt highly specific structures that can change with their level of activity, often through the direct or indirect action of other proteins. Indeed, proteins typically function within an ensemble, rather than individually. Hence, they must be sufficiently flexible to interact with each other and execute diverse tasks. The discovery that errors within these groups can ultimately cause disease has led to a paradigm shift in drug discovery, from an emphasis on single protein targets to a holistic approach whereby entire ensembles are targeted.
Potential Activity of Fevicordin-A from Phaleria macrocarpa (Scheff) Boerl. Seeds as Estrogen Receptor Antagonist Based on Cytotoxicity and Molecular Modelling Studies

Fevicordin-A (FevA) isolated from Phaleria macrocarpa (Scheff) Boerl. seeds was evaluated for its potential anticancer activity by in vitro and in silico approaches. Cytotoxicity studies indicated that FevA was selective against cell lines of human breast adenocarcinoma (MCF-7) with an IC50 value of 6.4 μM. At 11.2 μM, FevA resulted in 76.8% cell death of T-47D human breast cancer cell lines. Critical pharmacophore features amongst human Estrogen Receptor-α (hERα) antagonists were conserved in FevA with regard to a hypothesis that they could make notable contributions to its pharmacological activity. The binding stability as well as the dynamic behavior of FevA towards the hERα receptor in agonist and antagonist binding sites were probed using molecular dynamics (MD) simulation approach. Analysis of MD simulation suggested that the tail of FevA was accountable for the repulsion of the C-terminal of Helix-11 (H11) in both agonist and antagonist receptor forms. The flexibility of loop-534 indicated the ability to disrupt the hydrogen bond zipper network between H3 and H11 in hERα. In addition, MM/GBSA calculation from the molecular dynamic simulations also revealed a stronger binding affinity of FevA in antagonistic action as compared to that of agonistic action. Collectively, both the experimental and computational results indicated that FevA has potential as a candidate for an anticancer agent, which is worth promoting for further preclinical evaluation.
Citizen Centric Architecture Approach - Taking e-health forward by integrating citizens and service providers

In this paper, two related research problems will be discussed in the development of e-health services: First, an architectural approach is needed to provide a holistic view for solving the ICT challenges in e-health development. Second, solving the needs of the citizens should be the focus of the architecture solution. To overcome these problems we suggest a Citizen Centric Architecture (CCA) approach for providing a holistic and appropriately balanced view of the integration. Naturally, enterprises' information systems and citizens' information systems are the key elements of CCA. In addition, for solving the topology challenge brought by a large number of involved parties, a role of trusted third party is proposed to provide an environment for the information exchange and service mediation among the various parties. We believe this approach will enable the large scale growth in citizen centric e-health services that is poorly facilitated by the prevailing models: the improved integration of information will attract more citizens and health care service providers, which in turn, improve the health care information and quality of service.
Transient hypophagia in rats switched from high-fat diets with different fatty-acid pattern to a high-carbohydrate diet

The present study investigates the mechanisms underlying the transient hypophagia occurring when rats adapted to high-fat, carbohydrate-free diets are switched to high-carbohydrate, low-fat diets. The hypophagia after the high-fat, carbohydrate-free to high-carbohydrate, low-fat diet shift seems to depend on the amount of carbohydrate in the diet, since an attenuation of hypophagia was observed when high-fat, carbohydrate-free-adapted rats were switched to a medium-carbohydrate, medium-fat diet. A role of glucose intolerance in the hypophagia is supported by the attenuation of carbohydrate anorexia in rats adapted to a high-fat diet containing n -3 polyunsaturated fatty acids from fish oil (60% of fat as fish oil), which has been shown to improve glucose tolerance in rats. Furthermore, the increased plasma glucose concentration in the high-fat, carbohydrate-free diet to high-carbohydrate, low-fat shifted rats despite the suppression in food intake also suggests an involvement of glucose intolerance in the hypophagia. The failure of the inhibitor of hepatic-fatty-acid oxidation mercaptoacetate (400 micromol/kg, i.p.) to counteract carbohydrate anorexia in the HF-adapted rats argues against an involvement of fatty-acids oxidation in the inhibition of eating after high-fat, carbohydrate-free to high-carbohydrate, low-fat diet shift. This is also supported by the failure to demonstrate a relationship between plasma beta-hydroxybutyrate and the severity of the hypophagia. A role of leptin in the hypophagia seems unlikely, since plasma leptin after diet shift was unchanged. Ingestion of the high-carbohydrate, low-fat diet also produced an aversion towards this diet in high-fat, carbohydrate-free-adapted rats. It is concluded that the transient hypophagia induced by switching rats from a high-fat to a high-carbohydrate diet is not related to fatty acid oxidation but to transiently impaired carbohydrate utilization.
Mobile ActDresses: programming mobile devices by accessorizing

Mobile ActDresses is a design concept where existing practices of accessorizing, customization and manipulation of a physical mobile device is coupled with the behaviour of its software. With this interactivity demonstrator we will provide a hands on experience of doing this kind of playful manipulation. We provide two examples for how to implement Mobile ActDresses using quick'n dirty hacks to create custom shells and jewellery for controlling the behaviour of the phone.
Are Women More Likely to Vote for Women 's Issue Bills Than Their Male Colleagues?

votes indicate that gender exerts a significant and independent effect on voting for women's issues in the face of controls for other major influences on congressional voting. These influences include constituency factors, party, personal characteristics, and ideology. Interaction terms for gender by party indicate that much of the impact of gender is due to the influence of Republican women. Logit analysis of the individual votes demonstrates that the gender of the representative was most significant on votes that dealt with abortion and women's health. The influence of gender was overwhelmed by other factors such as party, ideology, and constituency concerns on votes that were less directly related to women, such as education.
Feature learning using state differences

The goal of General Game playing (GGP) can be described as designing computer programs that can play a variety of games when given a game description. Learning algorithms have not been an essential part of all successful GGP programs. This paper presents a feature learning approach, GIFL, for 2-player, alternating move games in GGP using state differences. The algorithm is simple, robust and improves the qual-
Vocational qualifications and progression to higher education: the case of the 14–19 Diplomas in the English system

Ensuring effective progression from vocational qualifications to higher education has become an important issue internationally as a part of government strategies to raise skill levels and to provide more equitable access to tertiary level study. From September 2008, the Government in England has begun to introduce a new set of qualifications for 14–19‐year‐olds, called Diplomas, intended to prepare young people for both employment and higher education. In competition with the traditional General Certificate of Education Advanced Levels, the reputation of the Diploma will depend on its ability to provide a progression route to university. Drawing on evidence from a variety of sources, including five seminars involving further education teachers, higher education admissions tutors and representatives of national agencies, this article suggests that the potential of the Diplomas to become a major route to higher education will be constrained by what we term a ‘low uptake, low understanding, low recognition and high complexity syndrome’. Using historical sources, the article also points to key similarities between the new Diplomas and the earlier, ill‐fated Advanced General National Vocational Qualifications as middle track awards in the English triple‐track qualifications system. We conclude by suggesting two contrasting possible strategies to address this issue.
YOGA: SOME UNANSWERED QUESTIONS

It is also possible that only individuals capable of such discipline will be found in the study to benefit from yoga as a means to mental health. Since most schools of psychotherapy invoke some form of psychological discipline, nonspecific factors may play a role in improvement with yoga. Here, the nonspecific factor is the capacity for and the utilization of psychological discipline. Discipline is just one example of a selection filter, or of a nonspecific factor in the mediation of improvement with yoga. Belief in yoga as a viable therapy is a second possible example. Capacity for relaxation is a third. Further examples are no less difficult to find.
Oral Biofilm Analysis of Palatal Expanders by Fluorescence In-Situ Hybridization and Confocal Laser Scanning Microscopy

Confocal laser scanning microscopy (CLSM) of natural heterogeneous biofilm is today facilitated by a comprehensive range of staining techniques, one of them being fluorescence in situ hybridization (FISH). 1,2 We performed a pilot study in which oral biofilm samples collected from fixed orthodontic appliances (palatal expanders) were stained by FISH, the objective being to assess the three-dimensional organization of natural biofilm and plaque accumulation.3,4 FISH creates an opportunity to stain cells in their native biofilm environment by the use of fluorescently labeled 16S rRNA-targeting probes.4-7,19 Compared to alternative techniques like immunofluorescent labeling, this is an inexpensive, precise and straightforward labeling technique to investigate different bacterial groups in mixed biofilm consortia.18,20 General probes were used that bind to Eubacteria (EUB338 + EUB338II + EUB338III; hereafter EUBmix),8-10 Firmicutes (LGC354 A-C; hereafter LGCmix),9,10 and Bacteroidetes (Bac303). 11 In addition, specific probes binding to Streptococcus mutans (MUT590)12,13 and Porphyromonas gingivalis (POGI)13,14 were used. The extreme hardness of the surface materials involved (stainless steel and acrylic resin) compelled us to find new ways of preparing the biofilm. As these surface materials could not be readily cut with a cryotome, various sampling methods were explored to obtain intact oral biofilm. The most workable of these approaches is presented in this communication. Small flakes of the biofilm-carrying acrylic resin were scraped off with a sterile scalpel, taking care not to damage the biofilm structure. Forceps were used to collect biofilm from the steel surfaces. Once collected, the samples were fixed and placed directly on polysine coated glass slides. FISH was performed directly on these slides with the probes mentioned above. Various FISH protocols were combined and modified to create a new protocol that was easy to handle.5,10,14,15 Subsequently the samples were analyzed by confocal laser scanning microscopy. Well-known configurations3,4,16,17 could be visualized, including mushroom-style formations and clusters of coccoid bacteria pervaded by channels. In addition, the bacterial composition of these typical biofilm structures were analyzed and 2D and 3D images created.
Web performance acceleration by caching rendering results

Web performance, the time from clicking a link on a web page to finishing displaying the web page of the link, is becoming increasingly important. Low web performance of web pages tends to result in the loss of customers. In our research, we measured the time for downloading files on popular web pages by running web browsers on four hosts worldwide using PlanetLab and detected the longest portion in download time. We found the longest portion in download time to be Blocked time, which is the waiting time for the start of downloading in web browsers. In this paper, we propose a method for accelerating web performance by reducing such Blocked time with a cache of rendering results. The proposed method uses an in-network rendering function which renders web pages instead of web browsers. The in-network rendering function also stores the rendering results in its cache and reuses them for other web browsers to reduce the Blocked time. To evaluate the proposed method, we calculated the web performance of web pages whose render results are cached by analyzing the measured download time of actual web pages. We found that the proposed method accelerates web performance of long round trip time (RTT) web pages or long RTT clients if the web pages' dynamic file percentages are within 80%.
Shared versus separate processes for letter and digit identification

Letters and digits, although similar in many respects, also differ in potentially significant ways. Most importantly, letters are elements of an alphabetic writing system, whereas digits are logographs. In this article, we explore whether letters and digits are identified by a single character identification process that makes no fundamental distinction between the two types of characters, or whether instead letter and digit identification processes diverge at least in some respects. We present evidence from an acquired dyslexic patient, L.H. D. , who is impaired in both letter and digit identification. Working within a theoretical framework specifying the levels of representation implicated in letter identification, we systematically compare L.H. D. 's letter and digit processing. The results provide evidence that letter and digit identification implicate the same levels of representation, and further that L.H. D. 's identification errors for both letters and digits arise at the same point in processing. On the basis of these results, we argue for a shared process that mediates identification of both letters and digits. Finally, we discuss relevant previous results in light of this conclusion.
NREM sleep instability is reduced in children with attention-deficit/hyperactivity disorder.

STUDY OBJECTIVES To evaluate non-rapid eye movement sleep instability (NREM), as measured by the cyclic alternating pattern (CAP), in a cohort of children with attention-deficit/hyperactivity disorder (ADHD) and normal controls. DESIGN Prospective study. SETTINGS Sleep laboratory. PARTICIPANTS Twenty consecutive outpatients with ADHD (18 boys and 2 girls; age range 6-13 years, mean age 9.3 years) and 20 normal children matched for age and socioeconomic status underwent polysomnographic recordings for 2 consecutive nights in a standard laboratory setting. Sleep was visually scored for sleep macrostructure and CAP, according to standard criteria. MEASUREMENTS AND RESULTS Children with ADHD showed significantly reduced sleep duration and increased rate of stage shifts. All children with ADHD had an apnea-hypopnea index less than 1. Those with ADHD presented lower total CAP rates and lower CAP rates during sleep stage 2 than did normal controls. Moreover, in children with ADHD, we found a lower number of CAP sequences and a reduced total A1 index, mainly in light sleep (sleep stages 1 and 2). We did not find differences in A subtype percentages, but there was a longer duration of A1 subtypes in children with ADHD. CONCLUSIONS Children with ADHD showed a lower CAP rate and a lower number of CAP sequences; this supports the hypothesis of the existence of a hypoarousal state in these patients.
Hegel and Metaphysics

As Fetscher put it in Marx and Marxism: “The relation between Marx and Hegel is not an academic problem. The different conceptions of the essential nature of Marx's doctrine correspond to different views concerning Marx's relations to Hegel. These relations in turn have both a theoretical and a political meaning. ” The following will re-examine one facet of Hegel which has remained obscure and which is Marx's most valuable inheritance from Hegel: the link between Marx's critical project, announced in a September 1843 letter to Ruge — “the relentless critique of everything that exists” — and the revolutionary password of the 11th Thesis on Feuerbach.