Miracle-dz/UniFAR-FTUs huggingface dataset:
Peer-to-Peer Information Retrieval: An Overview

Peer-to-peer technology is widely used for file sharing. In the past decade a number of prototype peer-to-peer information retrieval systems have been developed. Unfortunately, none of these has seen widespread real-world adoption and thus, in contrast with file sharing, information retrieval is still dominated by centralized solutions. In this article we provide an overview of the key challenges for peer-to-peer information retrieval and the work done so far. We want to stimulate and inspire further research to overcome these challenges. This will open the door to the development and large-scale deployment of real-world peer-to-peer information retrieval systems that rival existing centralized client-server solutions in terms of scalability, performance, user satisfaction, and freedom.
Facial Paralysis from Lyme Disease

EDITOR'S NOTE: Cases of facial paralysis In Lyme disease (a tick-borne spirochetal Infection) are being reported with Increasing frequency. and Its wide distribution In North America demands that all otolaryngologists be aware of this association. The presence of skin lesions and/or systemic symptoms In a patient with facial paralysis (especially bilateral) should alert the clinician. leUever reports a case of vertigo-clinIcally Indistinguishable from benign paroxysmal positional vertigo-and reduced vestibular response after the use of gentamicin In the middle ear. There Is considerable controversy about the safety of amlnoglycoslde ear drops: most European otologlsts consider their use In the middle ear Indefensible. while American experience has been quite different with no convincing evidence of SUbstantial risk. This single case does not resolve the matter, since the ponenrs vestibular problem could have arisen from Infection or even spontaneously, but It would seem wise to avoid long-term use of amlnoglycoslde drops through a dry perforation, as used In the reported case. Lusk and Babin offer a nicely documented case of synkinesis of masticatory muscles and tensor tympani after radlotrequency lesion of the trigeminal nerve; It isperhaps surprisingthat this does not happen more often.
Pharmacokinetics of the opioid antagonist N-methylnaltrexone and evaluation of its effects on gastrointestinal tract function in horses treated or not treated with morphine.

OBJECTIVE To determine the pharmacokinetics and effects of the morphine antagonist N-methylnaltrexone (MNTX) on gastrointestinal tract function in horses when administered alone and in combination with morphine. ANIMALS 5 healthy adult horses. PROCEDURES Horses were treated with MNTX (1 mg/kg, IV), and serial blood samples were collected for determination of drug pharmacokinetics. For evaluation of effects on the gastrointestinal tract when administered alone, MNTX was administered at a dosage of 0.75 mg/kg, IV, twice daily for 4 days. For evaluation of effects when administered concurrently with morphine, MNTX (0.75 mg/kg, IV, q 12 hours) and morphine (0.5 mg/kg, IV, q 12 hours) were administered for 6 days. Gastrointestinal variables evaluated were defecation frequency, weight of feces produced, fecal moisture content, intestinal transit time, and borborygmus scores. RESULTS The time-concentration data for MNTX disposition best fit a 2-compartment model with a steady-state volume of distribution of 244.6 +/- 21.8 mL/kg, t1/2 of 47.04 +/- 11.65 minutes, and clearance of 11.43 +/- 1.06 mL/min/kg. Adverse effects were not observed at doses <or= 1 mg/kg. Administration of MNTX increased daily fecal weight. When administered concurrently with morphine, MNTX partially prevented the effects of morphine on the gastrointestinal tract by increasing defecation frequency, fecal weight, fecal moisture content, and borborygmus score, and by preventing increases in intestinal transit time. CONCLUSIONS AND CLINICAL RELEVANCE Because MNTX does not cross the blood-brain barrier, administration of the drug should not alter the analgesic effects of opioids and may attenuate the adverse gastrointestinal effects associated with use of opioids in horses.
In Vivo Predictive Dissolution and Biopharmaceutic-Based In Silico Model to Explain Bioequivalence Results of Valsartan, a Biopharmaceutics Classification System Class IV Drug

The purpose of this study was to predict the in vivo bioequivalence (BE) outcome of valsartan (VALS, BCS class IV) from three oral-fixed combination products with hydrochlorothiazide (HCTZ, BCS class III) (Co-Diovan® Forte as reference and two generic formulations in development) by conducting in vivo predictive dissolution with a gastrointestinal simulator (GIS) and a physiologically based biopharmaceutic model (PBBM). In the first BE study, the HCTZ failed, but the VALS 90% CI of Cmax and the AUC were within the acceptance limits, while, in the second BE study, the HCTZ 90% CI of Cmax and the AUC were within the acceptance limits, but the VALS failed. As both drugs belong to different BCS classes, their limiting factors for absorption are different. On the other hand, the gastrointestinal variables affected by the formulation excipients have a distinct impact on their in vivo exposures. Dissolution tests of the three products were performed in a GIS, and a PBBM was constructed for VALS by incorporating in the mathematical model of the in vitro–in vivo correlation (IVIVC) the gastrointestinal variables affected by the excipients, namely, VALS permeability and GI transit time. VALS permeability in presence of the formulation excipients was characterized using the in situ perfusion method in rats, and the impact of the excipients on the GI transit times was estimated from the HCTZ’s in vivo results. The model was able to fit the in vivo BE results with a good prediction error. This study contributes to the field by showing the usefulness of PBBM in establishing in vitro–in vivo relationships incorporating not only dissolution data but also other gastrointestinal critical variables that affect drug exposure in BCS class IV compounds.
Neural Induction from ES Cells Portrays Default Commitment but Instructive Maturation

The neural induction has remained a debatable issue pertaining to whether it is a mere default process or it involves precise instructive cues. We have chosen the embryonic stem (ES) cell model to address this issue. In a devised monoculture strategy, the cell–cell interaction availed through optimum cell plating density could define the niche for the attainment of efficient in vitro neurogenesis from the ES cells. The medium plating density was found ideal in generating optimum number of progenitors and also yielded about 80% mature neurons in a serum free culture set up barring any exogenous inducers. We could also demarcate and quantify the neural stem cells/progenitors among the heterogeneous cell population of differentiating ES cells using nestin intron II driven EGFP expression as a tool. The one week post-plating was determined to be the critical time window for optimum neural progenitor generation from ES cells that helped us further in purifying these cells and in demonstrating their proliferation and multipotent differentiation potential. Seeding cells at varying densities, we could decipher an interesting paradoxical scenario that interlinked both commitment and maturation with the initial plating density having a vital influence on neuronal maturation but not specification and the secretory factors were apparently playing a key role during this process. Thus it was comprehended that, the neural specification was a default process independent of exogenous factors and cellular interaction. Conversely, a defined number of cells at the specification stage itself seemed critical to provide an auto-/paracrine means of signaling threshold for the maturation process to materialize.
Seasonal Variations in Vitamin D Levels and the Incident Dementia Among Older Adults Aged ≥60 Years in the UK Biobank

Background: Limited knowledge exists regarding the association between dementia incidence and vitamin D insufficiency/deficiency across seasons. Objective: This study aimed to evaluate the impact of seasonal serum vitamin D (25(OH)D) levels on dementia and its subtypes, considering potential modifiers. Methods: We analyzed 193,003 individuals aged 60–73 at baseline (2006–2010) from the UK Biobank cohort, with follow-up until 2018. 25(OH)D were measured at baseline, and incident dementia cases were identified through hospital records, death certificates, and self-reports. Results: Out of 1,874 documented all-cause dementia cases, the median follow-up duration was 8.9 years. Linear and nonlinear associations between 25(OH)D and dementia incidence across seasons were observed. In multivariable-adjusted analysis, 25(OH)D deficiency was associated with a 1.5-fold (95% CIs: 1.2–2.0), 2.2-fold (1.5–3.0), 2.0-fold (1.5–2.7), and 1.7-fold (1.3–2.3) increased incidence of all-cause dementia in spring, summer, autumn, and winter, respectively. Adjusting for seasonal variations, 25(OH)D insufficiency and deficiency were associated with a 1.3-fold (1.1–1.4) and 1.8-fold (1.6–2.2) increased dementia incidence, respectively. This association remained significant across subgroups, including baseline age, gender, and education levels. Furthermore, 25(OH)D deficiency was associated with a 1.4-fold (1.1–1.8) and 1.5-fold (1.1–2.0) higher incidence of Alzheimer’s disease and vascular dementia, respectively. These associations remained significant across all subgroups. Conclusions: 25(OH)D deficiency is associated with an increased incidence of dementia and its subtypes throughout the year.
Impact of antiplatelet therapy on microvascular thrombosis during ST-elevation myocardial infarction

During an acute coronary syndrome, atherosclerotic plaque rupture triggers platelet activation and thrombus formation, which may completely occlude a coronary artery leading to ST-elevation myocardial infarction (STEMI). Although emergency percutaneous coronary intervention (PCI) is effective in re-opening the main coronary arteries, the downstream microvasculature can become obstructed by embolised plaque material and thrombus. Dual antiplatelet therapy is recommended by guidelines and used routinely for the management of STEMI to reduce the risk of recurrent atherothrombotic events. However it is unclear to what extent antiplatelet therapy reduces microvascular thrombosis, largely because most tools to assess microvascular thrombosis only became available after antiplatelet therapy was already used in the majority of patients. Platelets play a central role in key aspects of microvascular thrombosis, such as atherosclerotic plaque-induced thrombus development, inflammation and microvascular dysfunction, making them a potential target for novel therapeutic interventions. Currently, more potent antiplatelet agents like GPIIb/IIIa inhibitors may be administered during PCI directly into coronary arteries with high thrombus burden but it is not well-established whether this reduces microvascular thrombosis and they significantly increase the risk of bleeding. In this review article we discuss the role of platelets in microvascular thrombosis, describe how microvascular thrombosis and obstruction can be assessed clinically and explore potential new antiplatelet treatments for this. In particular, we highlight novel antiplatelet drugs targeting the platelet receptor GPVI, as well as PAR4, GPIb-IX-V and 5HT2A receptors. We also discuss the potential benefit of P-selectin inhibitors as they have proven to be effective in reducing microvascular thrombosis in sickle-cell disease which could translate into potential benefits in acute coronary syndrome.
Oestrogen is a potent disease accelerator in SLE‐prone MRL lpr/lpr mice

The influence of oestrogen on the lupus disease in MRL/1 mice has been investigated. Adult, castrated male and female MRL/1 mice were administered with s.c. injections of 3–2 μg of 17β‐oestradiol twice a week. The results clearly demonstrate that a relatively small dose of oestrogen is a potent accelerator of the lupus disease in this mouse strain. Thus, administration of oestrogen accelerates glomerulonephritis, lymphoproliferation and mortality. Our results also indicate that oestrogen exerts a dual effect on the immune system of MRL/1 mice by depression of antigen‐specific and mitogen‐induced T cell responses as well as enhancement of polyclonal Bcell activation and autoantibody formation. In addition, even short‐term administration of oestrogen in the preclinical phase of the disease resulted in long‐lasting effects as evaluated by reduced longevity and aggravation of renal disease.
Model based concordance compression

The authors discuss concordance compression using the framework now customary in compression theory. They begin by creating a mathematical model of concordance generation, and then use optimal compression engines, such as Huffman or arithmetic coding, to do the actual compression. It should be noted that in the context of a static information retrieval system, compression and decompression are not symmetrical tasks. Compression is done only once, while building the system, whereas decompression is needed during the processing of every query and directly affects the response time. One may thus use extensive and costly preprocessing for compression, provided reasonably fast decompression methods are possible. Moreover, compression is applied to the full files (text, concordance, etc.), but decompression is needed only for (possibly many) short pieces, which may be accessed at random by means of pointers to their exact locations. Therefore the use of adaptive methods based on tables that systematically change from the beginning to the end of the file is ruled out. However, their concern is less the speed of encoding or decoding than relating concordance compression conceptually to the modern approach of data compression, and testing the effectiveness of their models. <<ETX>>
Responses of laboratory animals to some injectable anaesthetics

Xylazine, ketamine, methohexitone and alphadalone/alphaxalone, were administered intraperitoneally, intramuscularly or intravenously to mice, rats, guineapigs and rabbits. Times for disappearance and reappearance of reflexes were recorded, and duration of loss of reflex. Delivering a predetermined dose gave a varying individual response, ranging from inadequate anaesthesia to death. Using reflexes to assess depth of anaesthesia was of limited value. Reflex movements to noxious stimuli generally persisted even at dose rates that caused prolonged recovery times and death. Conversely, in rats there was no response to a cutaneous stimulus in some animals even though recumbency was almost restored.
Notes that Float: Applying content and context features to facilitate flexible reminding in notes-to-self

While physical note taking tools such as Post-Its afford lightweight reminding facilities through their ability to be situated in highly visible locations, available screen real estate limits how many digital notes we can have visible at the same time. In this paper, we present initial work towards achieving scalable lightweight reminding in large personal note collections, through Notes that Float (NTF), a system which automatically raises the salience of notes through the use of extracted content and learned contextual correlations with a user's activities, location and state.
STRENGTH AND CONDITIONING PRACTICES OF MAJOR LEAGUE BASEBALL STRENGTH AND CONDITIONING COACHES

This study describes the results of a survey of the practices of Major League Baseball strength and conditioning (MLB S&C) coaches. The response rate was 70.0% (21 of 30). This survey examines (a) background information, (b) physical testing, (c) flexibility development, (d) speed development, (e) plyometrics, (f) strength/power development, (g) unique aspects, and (h) comments. Results indicate, in part, that coaches assess an average of 3.6 parameters of fitness, with body composition testing being the most commonly assessed parameter. All coaches use a variety of flexibility development strategies. All coaches use speed development strategies, with form running drills being the most common. Twenty of 21 (95.2%) coaches employ plyometric exercises with their athletes. Eighteen of 21 (85.7%) of MLB S&C coaches follow a periodization model (PM). Five of 21 coaches (23.8%) indicated that their athletes use Olympic-style lifts. The squat and its variations and the lunge and its variations were most frequently identified as the first and second most important exercises used to train the athletes. This survey provides detailed information about strength and conditioning practices at the most competitive level of baseball and serves as a review, as well as a source of applied information and new ideas.
Cerebral Venous and Sinus Thrombosis in Women

Background and Purpose— Little is known about the gender-specific manifestations of cerebral venous and sinus thrombosis, a disease that is much more common in women than men. Methods— We used data of the International Study on Cerebral Vein and Dural sinus Thrombosis (ISCVT), a multicenter prospective observational study, to analyze gender-specific differences in clinical presentation, etiology, and outcome of cerebral venous thrombosis. Results— Four hundred sixty-five of a total of 624 patients were women (75%). Women were significantly younger, had less often a chronic onset of symptoms, and had more often headache at presentation. There were no gender differences in ancillary investigations or treatment. A gender-specific risk factor (oral contraceptives, pregnancy, puerperium, and hormonal replacement therapy) was present in 65% of women. Women had a better prognosis than men (complete recovery 81% versus 71%l P=0.01), which was entirely due to a better outcome in female patients with gender-specific risk factors. Women without gender-specific risk factors are similar to men in clinical presentation, risk factor profile, and outcome. Logistic regression analysis confirmed that the absence of gender-specific risk factors is a strong and independent predictor of poor outcome in women with sinus thrombosis (OR, 3.7; CI, 1.9 to 7.4). Conclusions— Our study identified important differences between women and men in presentation, course, and risk factors of cerebral venous and sinus thrombosis and showed that women with a gender-specific risk factor have a much better prognosis than other patients.
Systemic Exposure to Irradiated Apoptotic Cells Induces Autoantibody Production

During apoptotic cell death, cell surface ligands initiate phagocytosis of the dying cell. Clearance of these apoptotic cells is thought to occur without an immune response. Since a number of autoantigens are located at the cell surface or within apoptotic blebs, we examined whether exposure of mice to syngeneic apoptotic cells by the intravenous route could induce autoantibody production. Normal mice injected with syngeneic apoptotic thymocytes developed antinuclear autoantibodies and anticardiolipin and anti-ssDNA antibodies. The autoantibody levels were generally lower than those observed in MRL/Faslpr mice and were transient. Surprisingly, six out of six immunized mice demonstrated immunoglobulin G deposition in the glomeruli several months after immunization. These findings indicate that systemic exposure to apoptotic cells can induce an immune response in normal mice, and may help to explain antigen selection and initiation of the immune response in diseases characterized by increased rates of apoptosis such as AIDS and, possibly, systemic lupus erythematosus.
Efficacy and Safety of Pericapsular Nerve Group Block for Hip Fracture Surgery under Spinal Anesthesia: A Meta-Analysis

Objective To evaluate the effectiveness and safety of pericapsular nerve group (PENG) block for hip fracture surgery under spinal anesthesia. Methods This meta-analysis was registered on INPLASY (INPLASY202270005). PubMed, Embase, Cochrane, CNKI, and Wanfang databases were searched to collect the randomized controlled trials of the PENG block applied to hip fracture surgery in the setting of spinal anesthesia, with the search period from inception to 1 May 2023. Two independent researchers gradually screened the literature, evaluated the quality, extracted the data, and eventually pooled data using RevMan 5.4. Results Fifteen articles with 890 patients were enrolled. The combined results showed that the PENG block reduced pain scores during position placement (SMD = −0.35; 95% CI [−0.67, 0.02]; P=0.04; I2 = 0%). Subgroup analyses showed that compared to the unblocked group, the PENG block reduced pain scores at 12 h, 24 h, and 48 h postoperatively. The incidence of postoperative hypokinesia was reduced (RR = 0.11; 95% CI [0.01, 0.86]; P=0.04; I2 = 0.00%). The time to first walking was advanced (SMD = −0.90; 95% CI [−1.17, 0.63]; P < 0.00001; I2 = 0%). Conclusion The PENG block can reduce postoperative pain and pain during spinal anesthesia positioning, which is helpful to improve the operability and comfort of spinal anesthesia and facilitate postoperative muscle strength recovery and early activity.
A Storage Framework for Managing Scientific Data

In this paper, we present the design, implementation, and evaluation of PStore, a no-overwrite storage framework for managing large volumes of array data generated by scientific simulations. PStore consists of two modules, a data ingestion module and a query processing module, that respectively address two of the key challenges in scientific simulation data management. The data ingestion module is geared toward handling the high volumes of simulation data generated at a very rapid rate, which often makes it impossible to offload the data onto storage devices; the module is responsible for selecting an appropriate compression scheme for the data at hand, chunking the data, and then compressing it before sending it to the storage nodes. On the other hand, the query processing module is in charge of efficiently executing different types of queries over the stored data; in this paper, we specifically focus on dicing (also called range) queries. PStore provides a suite of compression schemes that leverage, and in some cases extend, existing techniques to provide support for diverse scientific simulation data. To efficiently execute queries over such compressed data, PStore adopts and extends a two-level chunking scheme by incorporating the effect of compression, and hides expensive disk latencies for long running range queries by exploiting chunk prefetching. In addition, we also parallelize the query processing module to further speed up execution. We evaluate PStore on a 140 GB dataset obtained from real-world simulations using the regional climate model CWRF [5]. In this paper, we use both 3D and 4D datasets and demonstrate high performance through extensive experiments.
Optimizing a green manure-based row cropping system for organic cereal production

A row cropping system with an increase of row distance to 24 cm increased the growth of undersown cover crops and allowed 1-2 passes of interow hoeing for weed control before sowing cover crops. The three-week delay sowing time was suitable for the growth of legume species. The new system significantly improved both grain yield and grain N content of the succeeding crop compared to the traditional cropping system.
Autoreactive B cells get activated in extrafollicular sites

Autoreactive B cells are prevented from producing autoantibodies that may cause pathogenicity in autoimmune diseases by the induction of tolerance. When autoreactive B cells escape regulation in autoimmune‐prone individuals, large amounts of autoantibodies are produced with somatic mutations in their variable regions. In this issue of the European Journal of Immunology, a new and very useful model is presented that induces activation and hypermutation of autoreactive B cells upon injection of chromatin‐containing immune complexes. The differentiation and hypermutation of autoreactive B cells takes place at extrafollicular sites.