Miracle-dz/UniFAR-FTUs huggingface dataset:
Names and higher-order functions

Many functional programming languages rely on the elimination of ‘impure’ features: assignment to variables, exceptions and even input/output. But some of these are genuinely useful, and it is of real interest to establish how they can be reintroducted in a controlled way. This dissertation looks in detail at one example of this: the addition to a functional language of dynamically generated names. Names are created fresh, they can be compared with each other and passed around, but that is all. As a very basic example of state, they capture the graduation between private and public, local and global, by their interaction with higher-order functions. The vehicle for this study is the nu-calculus, an extension of the simply-typed lambdacalculus. The nu-calculus is equivalent to a certain fragment of Standard ML, omitting side-effects, exceptions, datatypes and recursion. Even without all these features, the interaction of name creation with higher-order functions can be complex and subtle. Various operational and denotational methods for reasoning about the nu-calculus are developed. These include a computational metalanguage in the style of Moggi, which distinguishes in the type system between values and computations. This leads to categorical models that use a strong monad, and examples are devised based on functor categories. The idea of logical relations is used to derive powerful reasoning methods that capture some of the distinction between private and public names. These techniques are shown to be complete for establishing contextual equivalence between first-order expressions; they are also used to construct a correspondingly abstract categorical model. All the work with the nu-calculus extends cleanly to Reduced ML, a larger language that introduces integer references: mutable storage cells that are dynamically allocated. It turns out that the step up is quite simple, and both the computational metalanguage and the sample categorical models can be reused.
Nonfusion Treatment of Adolescent Idiopathic Scoliosis by Growth Modulation and Remodeling

BackgroundAdolescent idiopathic scoliosis (AIS) is a common disorder in which the spine gradually develops a curvature that is first detected in patients between 11 and 17 years of age. The only accepted treatment methods are bracing and surgery. Whether brace treatment alters the natural history is being questioned, and patient compliance is low. Surgery usually includes a spinal fusion that creates a rigid spine and concentrates stresses at the ends. MethodsThis study focuses on correlating the laboratory results with clinical reports for treating patients with AIS. In the laboratory, scoliosis with vertebral wedging has been created by asymmetric mechanical loading and has been corrected by reversing the loading. In the clinic, bracing and derotational casting have been successful in some reports, but compliance has been a problem with bracing and derotational casts have mainly been used in young children. Operative treatment has been successful, but a nonfusion operation remains elusive. Findings and ResultsIn the laboratory, axial loading of growth plates altered growth according to the Hueter-Volkmann law, which states that compression decreases and distraction increases growth. Asymmetric loading of the spine caused asymmetric growth resulting in scoliosis with vertebral wedging. Asymmetric loading of tail vertebrae created vertebral wedging according to Wolff's law, which states that the bone remodels over time in response to prevailing mechanical demands. In the clinic, studies have shown that bracing may work if patients wore the brace as prescribed. Derotational casting in young children has been shown to prevent progression and even correct the scoliosis in some patients. Convex vertebral stapling has been successful in mild curves, but the results in larger curves have been disappointing. Anterolateral tethering has been successful in mild curves in young patients, but there is limited experience with this technique in patients with large curves. ConclusionsA brace that applies the appropriate loading and is worn as prescribed may dramatically improve the results of brace treatment. A procedure using external fixation or adjustable anterolateral tethering may achieve a nonfusion correction of AIS. Level of EvidenceLevel II.
Differential actions of orexin receptors in brainstem cholinergic and monoaminergic neurons revealed by receptor knockouts: implications for orexinergic signaling in arousal and narcolepsy

Orexin neuropeptides influence multiple homeostatic functions and play an essential role in the expression of normal sleep-wake behavior. While their two known receptors (OX1 and OX2) are targets for novel pharmacotherapeutics, the actions mediated by each receptor remain largely unexplored. Using brain slices from mice constitutively lacking either receptor, we used whole-cell and Ca2+ imaging methods to delineate the cellular actions of each receptor within cholinergic [laterodorsal tegmental nucleus (LDT)] and monoaminergic [dorsal raphe (DR) and locus coeruleus (LC)] brainstem nuclei—where orexins promote arousal and suppress REM sleep. In slices from OX−/−2 mice, orexin-A (300 nM) elicited wild-type responses in LDT, DR, and LC neurons consisting of a depolarizing current and augmented voltage-dependent Ca2+ transients. In slices from OX−/−1 mice, the depolarizing current was absent in LDT and LC neurons and was attenuated in DR neurons, although Ca2+-transients were still augmented. Since orexin-A produced neither of these actions in slices lacking both receptors, our findings suggest that orexin-mediated depolarization is mediated by both receptors in DR, but is exclusively mediated by OX1 in LDT and LC neurons, even though OX2 is present and OX2 mRNA appears elevated in brainstems from OX−/−1 mice. Considering published behavioral data, these findings support a model in which orexin-mediated excitation of mesopontine cholinergic and monoaminergic neurons contributes little to stabilizing spontaneous waking and sleep bouts, but functions in context-dependent arousal and helps restrict muscle atonia to REM sleep. The augmented Ca2+ transients produced by both receptors appeared mediated by influx via L-type Ca2+ channels, which is often linked to transcriptional signaling. This could provide an adaptive signal to compensate for receptor loss or prolonged antagonism and may contribute to the reduced severity of narcolepsy in single receptor knockout mice.
Personalized prescribing: a new medical model for clinical implementation of psychotropic drugs

The use of pharmacogenetic tests was already being proposed in psychiatry in the early 2000s because genetic factors were known to influence drug pharmacokinetics and pharmacodynamics. However, sufficient levels of evidence to justify routine use have been achieved for only a few tests (eg, major histocompatibility complex, class I, B, allele 1502 [HLA-B*1502] for carbamazepine in epilepsy and bipolar disorders); many findings are too preliminary or, when replicated, of low clinical relevance because of a small effect size. Although drug selection and dose adaptation according to cytochrome P450 genotypes are sound, a large number of patients need to be genotyped in order to prevent one case of severe side effect and/or nonresponse. The decrease in cost for genetic analysis shifts the cost: benefit ratio toward increasing use of pharmacogenetic tests. However, they have to be combined with careful clinical evaluations and other tools (eg, therapeutic drug monitoring and phenotyping) to contribute to the general aim of providing the best care for psychiatric patients.
Alterations of neocortical neuronal responses to acetylcholine and GABA in rats born to alcohol-dependent mothers.

Alcohol is known to be a CNS teratogenic factor interfering with neuronal and synaptic maturation. The purpose of this microiontophoretic study was to explore GABAergic and cholinergic central mechanisms in adult rats exposed to alcohol in the third phase of prenatal life (ADM), when their mothers were subjected to alcohol physical dependence induction (9.6 g/kg/day). Responses to acetylcholine and GABA were recorded in frontal and somatosensory cortical neurons. Adult rats, whose mothers had been administered placebo with identical procedures, were used as a control (C). Cholinergic responses were significantly decreased and GABAergic responses increased in ADM animals with respect to controls. After a single i.p. alcohol injection (1.6 g/kg) spontaneous firing was depressed in ADM animals to a lesser extent than in C rats. Cholinergic excitations were reduced in C group and potentiated with reversal of atropine antagonism in ADM animals. GABAergic inhibitions were slightly increased and bicuculline antagonism was blocked in C rats, while ADM animals showed decreased responses to GABA. The present results support the hyperactivity of GABAergic system and the hypoactivity of cholinergic system reported in previous studies on prenatally and postnatally alcohol-exposed animals. Microiontophoretic results following ethanol injection led to the hypothesis that a rapid tolerance/dependence may develop in the offspring of alcohol-dependent rats.
Improving high level synthesis optimization opportunity through polyhedral transformations

High level synthesis (HLS) is an important enabling technology for the adoption of hardware accelerator technologies. It promises the performance and energy efficiency of hardware designs with a lower barrier to entry in design expertise, and shorter design time. State-of-the-art high level synthesis now includes a wide variety of powerful optimizations that implement efficient hardware. These optimizations can implement some of the most important features generally performed in manual designs including parallel hardware units, pipelining of execution both within a hardware unit and between units, and fine-grained data communication. We may generally classify the optimizations as those that optimize hardware implementation within a code block (intra-block) and those that optimize communication and pipelining between code blocks (inter-block). However, both optimizations are in practice difficult to apply. Real-world applications contain data-dependent blocks of code and communicate through complex data access patterns. Existing high level synthesis tools cannot apply these powerful optimizations unless the code is inherently compatible, severely limiting the optimization opportunity. In this paper we present an integrated framework to model and enable both intra- and inter-block optimizations. This integrated technique substantially improves the opportunity to use the powerful HLS optimizations that implement parallelism, pipelining, and fine-grained communication. Our polyhedral model-based technique systematically defines a set of data access patterns, identifies effective data access patterns, and performs the loop transformations to enable the intra- and inter-block optimizations. Our framework automatically explores transformation options, performs code transformations, and inserts the appropriate HLS directives to implement the HLS optimizations. Furthermore, our framework can automatically generate the optimized communication blocks for fine-grained communication between hardware blocks. Experimental evaluation demonstrates that we can achieve an average of 6.04X speedup over the high level synthesis solution without our transformations to enable intra- and inter-block optimizations.
Headache in stroke

Background: Many aspects of stroke-related headache, such as its incidence, pathophysiology, risk factors, and relation to stroke severity and outcome, are uncertain. Design: A prospective, community-based study including 1,128 consecutive acute stroke patients; 867 (77%) were able to communicate. Stroke severity and the clinical course were assessed using the Scandinavian Stroke Scale (SSS). CT was performed in 84% of patients. In the data analysis, multivariate regression analyses were used when appropriate. Results: Two hundred forty-one (28%) of the 867 patients had headache in relation to stroke onset. Independent risk factors were age (odds ratio [OR] per 20 years, 0.57; 95% confidence interval [CI], 0.43 to 0.86; p = 0.0001), female sex (OR, 1.6; CI, 1.2 to 2.2; p = 0.003), intracerebral hemorrhage (OR, 2.8; CI, 1.5 to 5.4; p = 0.002), stroke in the vertebrobasilar territory (OR, 1.7; CI, 1.1 to 2.3; p = 0.02), and ischemic heart disease (OR, 1.5; CI, 1.1 to 2.2; p = 0.01). In those patients in whom headache was lateralized (46%), it was ipsilateral to the lesion in 68% of cases (p = 0.01). There was no correlation between headache and (1) initial stroke severity as measured with the SSS (p = 0.75), (2) lesion size (p = 0.77), (3) whether or not CT showed cortical involvement (p = 0.29), (4) stroke outcome as measured with the SSS (p = 0.9), or (5) mortality (p = 0.75). Conclusion: Stroke-related headache is associated with factors such as age and sex. In patients capable of providing reliable headache information, headache is more frequent in strokes confined to the vertebrobasilar than to the carotid territory and is not associated with stroke severity or whether or not the cortex was involved. Stroke-related headache is not related to stroke outcome.
Protein synthesis in fast and slow muscles of developing cockerels loaded with 2G for 3 weeks.

BACKGROUND In our previous study, the increment of RNA and protein content ratios against body weight in the whole skeletal muscle were determined in young developing cockerels under 2G hypergravity for 3 weeks. In the present study, protein synthesis rate, RNA activity and protein content were investigated in different types of muscles [slow muscle (soleus) and fast muscle (extensor digitorum longus; EDL)] in similar experimental conditions. HYPOTHESIS It is believed that slow and fast muscle will show different responses to hypergravity. METHOD Young cockerels were raised standing vertically in a centrifuge and lived in a hypergravity (2G) environment for 3 weeks. At the end of the 3 weeks, the soleus and EDL muscles in their legs were immediately removed and the protein and RNA extracted. The fractional rate of protein synthesis in the muscles were determined by incorporation of L-[4-3H]-phenylalanine. RESULTS The feed intake of centrifuged cockerels was reduced on the first day but recovered on the second day. Thus, the growth curve was parallel although 2G-loaded cockerels were smaller in size. In a slow muscle (soleus) the protein synthesis rate, protein content and muscle mass were significantly increased after 2G loading. While fast muscle (EDL) protein synthesis rate (Ks) and RNA activity decreased, muscle mass and protein content had no significant change in the 2G loading group. CONCLUSION Soleus, which supports the body against gravity, apparently responded to hypergravity, while EDL may be repressed in protein turnover under the same condition. These findings imply that slow and fast muscles show different responses to hypergravity according to their function.
Security Weaknesses Detection by Symbolic Analysis of Scenarios

Remotely-communicating software-based systems are tightly present in modern industrial society and securing their complex architecture is recognized as crucial. In particular, the perspectives to reinforce their security by monitoring are promising. However, monitoring schemes still face challenges as the presence of untrusted components seems unavoidable. Specially, since untrusted components may be placed in unsupervised areas, making them ideal targets for attackers. In this work, we propose a framework intended to support designers during systems conception. The approach mainly relies upon Security Watchdogs committed to detect and signal distrustful activity. A model-based framework is introduced to ease attacks descriptions upon scenarios in the form of UML sequence diagrams. The scenarios endowed with predefined attack patterns are analyzed using models transformations and symbolic techniques. By doing so, the effectiveness of watchdogs is confronted against attacks and the results can be used to reinforce the overall security of the system. The applicability of the proposed method is also shown by means of a Smart Grid case study.
A Solution for Privacy Protection in MapReduce

Recently, the development of storage and networking technology have made processing tremendous data become real. As a result, the demand of discovering knowledge from the bigdata by using tools such as statistical analysis and data mining become higher. Using MapReduce a software framework introduced by Google in 2004 to implement computations on clusters of commodity computers is an economical solution. However, malicious MapReduce framework or source codes can leak the sensitive data through computation process. Giving user the least privilege on MapReduce-based system can solve the problem. Therefore, in our research, we propose a MapReduce-based computational system limiting the access to system resource by using RBAC and TE. Moreover, noise were added to the output of the Reduce to ensure the computational result can not signal the presence of a sensitive data. Our prototype implementation demonstrates the efficiency of preserving privacy on several cases.
Pivotal Role of a gp91phox-Containing NADPH Oxidase in Angiotensin II-Induced Cardiac Hypertrophy in Mice

Background—Angiotensin II induces both cardiac and vascular smooth muscle (VSM) hypertrophy. Recent studies suggest a central role for a phagocyte-type NADPH oxidase in angiotensin II-induced VSM hypertrophy. The possible involvement of an NADPH oxidase in the development of cardiac hypertrophy has not been studied. Methods and Results—Mice with targeted disruption of the NADPH oxidase subunit gp91phox (gp91phox−/−) and matched wild-type mice were subjected to subcutaneous angiotensin II infusion at a subpressor dose (0.3 mg/kg/day) for 2 weeks. Systolic blood pressure was unaltered by angiotensin II in either group. Angiotensin II significantly increased heart/body weight ratio, atrial natriuretic factor and &bgr;-myosin heavy chain mRNA expression, myocyte area, and cardiac collagen content in wild-type but not gp91phox−/− mice. Angiotensin II treatment increased myocardial NADPH oxidase activity in wild-type but not gp91phox−/− mice. Conclusions—A gp91phox-containing NADPH oxidase plays an important role in the development of angiotensin II-induced cardiac hypertrophy, independent of changes in blood pressure.
Guaranteed Cost Control of Polynomial Fuzzy Systems via a Sum of Squares Approach

This paper presents the guaranteed cost control of polynomial fuzzy systems via a sum of squares (SOS) approach. First, we present a polynomial fuzzy model and controller that are more general representations of the well-known Takagi-Sugeno (T-S) fuzzy model and controller, respectively. Second, we derive a guaranteed cost control design condition based on polynomial Lyapunov functions. Hence, the design approach discussed in this paper is more general than the existing LMI approaches (to T-S fuzzy control system designs) based on quadratic Lyapunov functions. The design condition realizes a guaranteed cost control by minimizing the upper bound of a given performance function. In addition, the design condition in the proposed approach can be represented in terms of SOS and is numerically (partially symbolically) solved via the recent developed SOSTOOLS. To illustrate the validity of the design approach, two design examples are provided. The first example deals with a complicated nonlinear system. The second example presents micro helicopter control. Both the examples show that our approach provides more extensive design results for the existing LMI approach.
Cervical Precancer Risk in HIV-Infected Women Who Test Positive for Oncogenic Human Papillomavirus Despite a Normal Pap Test.

BACKGROUND Determining cervical precancer risk among human immunodeficiency virus (HIV)-infected women who despite a normal Pap test are positive for oncogenic human papillomavirus (oncHPV) types is important for setting screening practices. METHODS A total of 2791 HIV-infected and 975 HIV-uninfected women in the Women's Interagency HIV Study were followed semiannually with Pap tests and colposcopy. Cumulative risks of cervical intraepithelial neoplasia grade 2 or greater (CIN-2+; threshold used for CIN treatment) and grade 3 or greater (CIN-3+; threshold to set screening practices) were measured in HIV-infected and HIV-uninfected women with normal Pap tests, stratified by baseline HPV results, and also in HIV-infected women with a low-grade squamous intraepithelial lesion (LSIL; benchmark indication for colposcopy). RESULTS At baseline, 1021 HIV-infected and 518 HIV-uninfected women had normal Pap tests, of whom 154 (15%) and 27 (5%), respectively, tested oncHPV positive. The 5-year CIN-2+ cumulative risk in the HIV-infected oncHPV-positive women was 22% (95% confidence interval [CI], 9%-34%), 12% (95% CI, 0%-22%), and 14% (95% CI, 2%-25%) among those with CD4 counts <350, 350-499, and ≥500 cells/µL, respectively, whereas it was 10% (95% CI, 0%-21%) in those without HIV. For CIN-3+, the cumulative risk averaged 4% (95% CI, 1%-8%) in HIV-infected oncHPV-positive women, and 10% (95% CI, 0%-23%) among those positive for HPV type 16. In HIV-infected women with LSIL, CIN-3+ risk was 7% (95% CI, 3%-11%). In multivariate analysis, HIV-infected HPV16-positive women had 13-fold (P = .001) greater CIN-3+ risk than oncHPV-negative women (referent), and HIV-infected women with LSIL had 9-fold (P < .0001) greater risk. CONCLUSIONS HIV-infected women with a normal Pap result who test HPV16 positive have high precancer risk (similar to those with LSIL), possibly warranting immediate colposcopy. Repeat screening in 1 year may be appropriate if non-16 oncHPV is detected.
Digest Generation of Kindergarten Surveillance Video with Location Information and Visual Features

In this paper, we address the task of automatic digest generating of video data taken from kindergarten surveillance cameras. Our objective is extracting and merging video segments to recode children's daily life. In order to deal with mass video data efficiently, we jointly utilize location information and visual features to segment raw material videos. Our proposed method involves two steps. The first is to narrow down the searching space by analyzing the noisy RFID tag log which records kids' temporal location, while the second is to evaluate the quality of each unit video segment by combine multiple visual features. By merging high score unit segments, our method promises to efficiently provide high quality digest that could reflect kids' daily activities.