Miracle-dz/UniFAR-FTUs huggingface dataset:
The Poincaré Series Of Stretched Cohen-Macaulay Rings

There are relatively few classes of local rings (R, m) for which the question of the rationality of the Poincaré series where k = R/m, has been settled. (For an example of a local ring with non-rational Poincaré series see the recent paper by D. Anick, “Construction of loop spaces and local rings whose Poincaré—Betti series are nonrational”, C. R. Acad. Sc. Paris 290 (1980), 729-732. ) In this note, we compute the Poincaré series of a certain family of local Cohen-Macaulay rings and obtain, as a corollary, the rationality of the Poincaré series of d-dimensional local Gorenstein rings (R, m) of embedding dimension at least e + d – 3, where e is the multiplicity of R. It follows that local Gorenstein rings of multiplicity at most five have rational Poincaré series.
Molecular Characterization of Nine TRAF Genes in Yellow Catfish (Pelteobagrus fulvidraco) and Their Expression Profiling in Response to Edwardsiella ictaluri Infection

The yellow catfish (Pelteobagrus fulvidraco) is an economic fish with a large breeding scale, and diseases have led to huge economic losses. Tumor necrosis factor receptor-associated factors (TRAFs) are a class of intracellular signal transduction proteins that play an important role in innate and adaptive immune responses by mediating NF-κB, JNK and MAPK signaling pathways. However, there are few studies on the TRAF gene family in yellow catfish. In this study, the open reading frame (ORF) sequences of TRAF1, TRAF2a, TRAF2b, TRAF3, TRAF4a, TRAF4b, TRAF5, TRAF6 and TRAF7 genes were cloned and identified in yellow catfish. The ORF sequences of the nine TRAF genes of yellow catfish (Pf_TRAF1-7) were 1413–2025 bp in length and encoded 470–674 amino acids. The predicted protein structures of Pf_TRAFs have typically conserved domains compared to mammals. The phylogenetic relationships showed that TRAF genes are conserved during evolution. Gene structure, motifs and syntenic analyses of TRAF genes showed that the exon–intron structure and conserved motifs of TRAF genes are diverse among seven vertebrate species, and the TRAF gene family is relatively conserved evolutionarily. Among them, TRAF1 is more closely related to TRAF2a and TRAF2b, and they may have evolved from a common ancestor. TRAF7 is quite different and distantly related to other TRAFs. Real-time quantitative PCR (qRT-PCR) results showed that all nine Pf_TRAF genes were constitutively expressed in 12 tissues of healthy yellow catfish, with higher mRNA expression levels in the gonad, spleen, brain and gill. After infection with Edwardsiella ictaluri, the expression levels of nine Pf_TRAF mRNAs were significantly changed in the head kidney, spleen, gill and brain tissues of yellow catfish, of which four genes were down-regulated and one gene was up-regulated in the head kidney; four genes were up-regulated and four genes were down-regulated in the spleen; two genes were down-regulated, one gene was up-regulated, and one gene was up-regulated and then down-regulated in the gill; one gene was up-regulated, one gene was down-regulated, and four genes were down-regulated and then up-regulated in the brain. These results indicate that Pf_TRAF genes might be involved in the immune response against bacterial infection. Subcellular localization results showed that all nine Pf_TRAFs were found localized in the cytoplasm, and Pf_TRAF2a, Pf_TRAF3 and Pf_TRAF4a could also be localized in the nucleus, uncovering that the subcellular localization of TRAF protein may be closely related to its structure and function in cellular mechanism. The results of this study suggest that the Pf_TRAF gene family plays important roles in the immune response against pathogen invasion and will provide basic information to further understand the roles of TRAF gene against bacterial infection in yellow catfish.
Evaluation of the Effects of Fertilization and Drying Methods on Pre and Post Aflatoxin Infection in Maize under Busogo Climatic Conditions

The research was conducted in the years of 2020-2021 during the growing seasons such as 2021A started from September 2020 till the end of January 2021 and 2021 B started from February till end of June 2021, in Busogo sector, Musanze District, Northern Province. The purpose of this project was to assess the impact of fertilization and drying methods such as sun drying, dry shelter and kitchen drying on aflatoxin contamination in maize before and after harvesting. The area from which this project was conducted was chosen due to the availability of a lot of number of maize growers who cultivate them not only for consumption but also for trade purpose either processed or non-processed. During this study, a total of twenty-four samples were collected, examined and evaluated for aflatoxin levels in both seasons. In the season 2021A and 2021B sample collection equivalent to twelve in each season was done then dried them within 30 days by using different drying methods such as dry shelter, kitchen drying, sun drying. Randomized Complete Block Design (RCBD) with four treatment of fertilizer combination in four replications was used in this study and all experimental plots were planted with one maize variety (H628) purchased from Rwanda Agriculture and Animal Resources Development Board. Except samples from maize cultivated without fertilizer, level of aflatoxin infection was found to be higher 10 Parts per billion. The East African countries community standard limit of 10 parts per billion which indicate a health risk to the consumer, when comparing the three drying methods employed in this study, the kitchen drying method produced lower levels of aflatoxin (1.6 parts per billion) than the dry shelter (3.2 parts per billion) and sun drying methods (2.9 parts per billion), samples taken from the control plot (T4) stands for no fertilizer application resulted greater levels of aflatoxin with an average of 25.75 prts per billion compared to other treatments which yielded aflatoxin levels of at lower than 10 parts per billion. The use of kitchen drying can be recommended as well as mixture of both organic and inorganic fertilizers when growing maize in order to reduce the level of aflatoxin.
Protocol summary and statistical analysis plan for the randomized trial of early detection of clinically significant prostate cancer (ProScreen)

Introduction: Evidence on the effectiveness of prostate cancer screening based on prostate-specific antigen is inconclusive and suggests a questionable balance between benefits and harms due to overdiagnosis. However, diagnostic accuracy studies have shown that detection of clinically insignificant prostate cancer can be reduced by magnetic resonance imaging combined with targeted biopsies. The aim of the paper is to describe the analysis of the ProScreen randomized trial to assess the performance of the novel screening algorithm in terms of the primary outcome, prostate cancer mortality, and secondary outcomes as intermediate indicators of screening benefits and harms of screening. Methods: The trial aims to recruit at least 111,000 men to achieve sufficient statistical power for the primary outcome. Men will be allocated in a 1:3 ratio to the screening and control arms. Interim analysis is planned at 10 years of follow-up, and the final analysis at 15 years. Difference between the trial arms in prostate cancer mortality will be assessed by Gray's test using intention to screen analysis of randomized men. Secondary outcomes will be the incidence of prostate cancer by disease aggressiveness, progression to advanced prostate cancer, death due to any cause and cost-effectiveness of screening. Ethics and dissemination: The trial protocol was reviewed by the ethical committee of the Helsinki University Hospital (HUS 2910/2017). Results will be disseminated in an international peer-reviewed journal(s) and at scientific meetings. Trial Registration: NCT03423303
Surveillance strategies for the detection of new SARS-CoV-2 variants across epidemiological contexts

Rapid identification of new SARS-CoV-2 variants is a critical component of the public health response to the COVID-19 pandemic. However, we lack a quantitative framework to assess the expected performance of sampling strategies in varying epidemic contexts. To address this gap, we used a multi-patch stochastic model of SARS-CoV-2 spread in New York City to evaluate the impact of the volume of testing and sequencing, geographic representativeness of sampling, location and timing of variant emergence, and relative variant transmissibility on the time to first detection of a new variant. The strategy of targeted sampling of likely emergence locations offered the most improvement in detection speed. Increasing sequencing capacity reduced detection time more than increasing testing volumes. The relative transmissibility of the new variant and the epidemic context of variant emergence also influenced detection times, showing that individual surveillance strategies can result in a wide range of detection outcomes, depending on the underlying dynamics of the circulating variants. These findings help contextualize the design, interpretation, and trade-offs of genomic surveillance strategies.
Disturbance Observer based Backstepping Control for Electro-hydraulic Position Servo System of the Projectile Coordination Arm

Due to the existence of unmodeled friction and unknown load disturbance, the position tracking control of electro-hydraulic position servo system of projectile coordination arm becomes an important problem to be solved urgently. In this paper, a dynamic surface backstepping control strategy is proposed based on the disturbance observer(DOB). To be specific, the disturbance observer is applied to estimate the unknown disturbance force, and the backstepping controller realizes the position tracking control. In order to improve the position tracking performance, The estimated value of the observer output is brought into the backstepping controller to realize the model compensation of the disturbance. Meanwhile, the dynamic surface method is utilized to handle the differential explosion problem in the backstepping method. The global stability of the closed-loop system is verified by Lyapunov stability theory. The co-simulation results show that the proposed method can effectively compensate the unknown disturbance in the electro-hydraulic position servo system, and has better tracking performance and strong robustness.
Development and Application of Intelligent Test Data Management Platform of Military Product Model Project

This paper first introduces the composition of the intelligent test data management platform of military product model project, which has the functions of data file management, acquisition, tagging, pre-processing, archiving, intelligent analysis and judgement, etc. Then the software module design of the platform and the main functions of each module are described. Finally, the advantages of the platform, such as easy operation, practicability, expansibility, easy management, easy maintenance and intelligentization, and the problems that need to be optimized are discussed.
Agricultural fallows are the main driver of natural forest regeneration in Tanzania

Rates and drivers of natural forest regeneration are areas of uncertainty for policy, forest management and climate change mitigation. In this study, the rate of deforestation and the rate and drivers of natural regeneration are described for 56 million hectares of village land in Tanzania, a country undergoing rapid deforestation. To determine the regeneration and deforestation rates, remote sensing (RS) data for 500 randomly selected points were reviewed for a 34 year period from 1987 to 2021 using Google Earth Engine. Over this period, regeneration, involving a transition from forest to non-forest and back to forest was detected on 4.8% of village land (95% CI: 3.1%–7.1%), while 0.8% of land transitioned from non-forest to forest (95% CI: 0.2%–2.04%). 22% of village land was deforested (95% CI: 18.6%–26.1%), equivalent to a mean annual net loss of 0.35 million hectares of forest. Using a combination of RS data, field plots and structured interviews, the land cover change trajectories of 180 regenerating plots, in 10 sampling clusters, were assessed to identify regeneration drivers and assess biomass and tree species accumulation rates. Agricultural fallows are the regeneration driver in 47% of plots (95% CI: 39.8%–54.8%). Other common regeneration drivers include abandonment of cultivated areas for reasons apart from fallowing, conservation and post wood-extraction abandonment in 19% (95% CI: 13.9%–26%), 18.3% (95% CI: 13%–24.8%) and 12.8% (95% CI: 8.3%–18.6%) of plots, respectively. The mean carbon sequestration rate was 1.4 Mg C ha−1 y−1, equivalent to 4.3 Tg C y−1 (95% CI: 3.9–4.7 Tg C y−1) across the 3.15 million hectares of regenerating village land forest. The mean species accumulation rate was 1.08 species y−1 (95% CI: 1.0–1.2). Regeneration time, location and precipitation have the greatest influence on biomass and species richness. The study highlights the potential for natural regeneration to contribute to global and national climate and biodiversity goals and to sustainable, productive forest management. The importance of cooperation and policy-alignment between the forest, agriculture and land sectors are under-scored.
Faint but Not Forgotten. I. First Results from a Search for Astrospheres around AGB Stars in the Far-ultraviolet

Using the GALEX archive, we have discovered extended structures around ten asymptotic giant branch (AGB) stars (out of a total 92 searched) emitting in the far-ultraviolet (FUV) band. In all but one, we find the typical morphology expected for a spherical wind moving relative to, and interacting with, the interstellar medium (ISM) to produce an astrosphere. The exception is V Hya whose mass ejection is known to be highly aspherical, where we find evidence of its large parabolic outflows interacting with the ISM, and its collimated, extreme velocity outflows interacting with the circumstellar medium. For eight objects with relatively large proper motions, we find (as expected) that the termination-shock region lies in a hemisphere that contains the proper motion vector. Radial intensity cuts for each source have been used to locate the termination shock and the astropause’s outer edge. In a few objects, the cuts also reveal faint emission just outside the astropause that likely arises in shocked ISM material. We have used these data, together with published mass-loss rates and wind expansion velocities, to determine the total mass lost and duration for each source—we find that the duration of and total mass in the shocked wind are significantly larger than their corresponding values for the unshocked wind. The combination of FUV and far-IR data on AGB astrospheres provides a unique database for theoretical studies (numerical simulations) of wind–ISM interactions. We show that a Cyclical Spatial Heterodyne Spectrometer on a small space-based telescope can provide high-resolution spectra of astrospheres to confirm the emission mechanism.
Effectiveness of interventions to address different types of vulnerabilities in community‐dwelling older adults: An umbrella review

Abstract Background Frailty, social isolation, loneliness, and poverty may render older adults vulnerable to social or health stressors. It is imperative to identify effective interventions to address them especially in the context of COVID‐19 pandemic. Objective To identify effective community‐based interventions to address frailty, social isolation, loneliness, and poverty among community‐dwelling older adults. Design Umbrella review. Data Source We systematically searched PubMed, Ovid MEDLINE, Embase, Cochrane CENTRAL, EBM‐Reviews, CINAHL via EBSCO, and APA PsycInfo via Ovid from January 2009 to December 2022. Eligibility Criteria We included systematic reviews or quantitative reviews of non‐pharmacologic interventions targeting community‐dwelling older adults. Data Selection, Extraction, and Management Two review authors independently screened the titles and abstracts, performed data extraction and appraised the methodological quality of the reviews. We used a narrative synthesis approach to summarize and interpret the findings. We assessed the methodological quality of the studies using AMSTAR 2.0 tool. Results We identified 27 reviews incorporating 372 unique primary studies that met our inclusion criteria. Ten of the reviews included studies conducted in low‐middle‐income countries. Twelve reviews (46%, 12/26) included interventions that addressed frailty. Seventeen reviews (65%, 17/26) included interventions that addressed either social isolation or loneliness. Eighteen reviews included studies with single component interventions, while 23 reviews included studies with multi‐component interventions. Interventions including protein supplementation combined with physical activity may improve outcomes including frailty status, grip strength, and body weight. Physical activity alone or in combination with diet may prevent frailty. Additionally, physical activity may improve social functioning and interventions using digital technologies may decrease social isolation and loneliness. We did not find any review of interventions addressing poverty among older adults. We also noted that few reviews addressed multiple vulnerabilities within the same study, specifically addressed vulnerability among ethnic and sexual minority groups, or examined interventions that engaged communities and adapted programs to local needs. Conclusion Evidence from reviews support diets, physical activity, and digital technologies to improve frailty, social isolation or loneliness. However, interventions examined were primarily conducted under optimal conditions. There is a need for further interventions in community settings and conducted under real world settings in older adults living with multiple vulnerabilities.
Drivers of power line collisions and electrocutions of birds in Nepal

Abstract Among the several anthropogenic factors, power lines are increasingly regarded as one of the most significant hazards to bird species, primarily owing to collisions and electrocutions. Nepal has comparatively fewer studies on the impact of power line collisions and electrocution on birds compared with developed nations. From November 2021 to May 2022, we assessed the effect of power line collisions and electrocutions on the mortality of birds in the Putalibazar Municipality of the Syangja district of Nepal. We established 117 circular plots in diverse habitats, including agricultural lands, forests, settlements, and river basins, along a 30.6 km long distribution line. Within 18 plots, we detected 43 fatalities of 11 species (17 individuals of six species due to collision and 26 individuals of eight species due to electrocution). House Swift (Apus nipalensis) and Common Myna (Acridotheres tristis) were the primary victims of the collision, whereas House Crow (Corvus splendens) and Rock Pigeon (Columba livia) were frequently observed electrocuted. We also recorded the electrocution of the critically endangered White‐rumped Vulture (Gyps bengalensis). The total rate of bird power line collisions per kilometer was 0.55 birds, while the total electrocution rate per 10 poles was 2.22. The bird abundance, distance to agricultural regions, and proximity to human settlements were found to have a strong relationship with the mortality of birds caused by power lines. In order to reduce power line collisions and electrocution fatalities, we recommend conducting a detailed bird population study prior to determining the route of distribution lines.
The Effect of the Saffron Intervention on NAFLD Status and Related Gene Expression in a Rat Model

Background According to the worldwide increasing prevalence of non-alcoholic fatty liver disease (NAFLD), the present study aimed to investigate the mechanism effects of saffron consumption on preventing NAFLD in a rat model. Methods In an experimental study, 12 rats were randomly divided into 2 groups to be evaluated in the prevention phase for 7 weeks. In the prevention phase, the animals were randomly assigned to either fed HFHS + 250 mg/kg saffron (S) or fed with HFHS. Afterward, parts of the liver were excised for histopathologic examination. Plasma concentrations of ALT, AST, GGT, ALP, serum lipids, insulin concentrations, plasma glucose, hs-CRP, and TAC were measured. Moreover, Also, the gene expression of 6 target genes was evaluated, including FAS, ACC1, CPT1 ،PPARα ،DGAT2, and SREBP 1-c at the beginning and end of the study. Also, the differences among groups were evaluated by the Mann-Whitney test for non-normal data and the independent t test for normal data. Results The prevention phase groups have a significant elevation in body weight ( P = 0.034) and food intake (P = 0.001) of the HFHS group versus HFHS + 250 mg/kg S group. Also, there was a significant difference between groups 1 and 2 for ALT (P = 0.011) and AST (P = 0.010), and TG (P = 0.040). The HFHS group had higher plasma levels of FBS (P = 0.001), insulin (P = 0.035), HOMA-IR (P = 0.032), and lower TAC (P = 0.041) versus the HFHS+ S group. Also, the difference between HFHS + 250 mg/kg S and HFHS for PPARα gene expression was significant (P = 0.030). Conclusion The present study showed that consumption of saffron could prevent developing NAFLD in rats at least partially through modulation in gene expression of PPARα.
Artificially-generated consolidations and balanced augmentation increase performance of U-net for lung parenchyma segmentation on MR images

Purpose To improve automated lung segmentation on 2D lung MR images using balanced augmentation and artificially-generated consolidations for training of a convolutional neural network (CNN). Materials and methods From 233 healthy volunteers and 100 patients, 1891 coronal MR images were acquired. Of these, 1666 images without consolidations were used to build a binary semantic CNN for lung segmentation and 225 images (187 without consolidations, 38 with consolidations) were used for testing. To increase CNN performance of segmenting lung parenchyma with consolidations, balanced augmentation was performed and artificially-generated consolidations were added to all training images. The proposed CNN (CNNBal/Cons) was compared to two other CNNs: CNNUnbal/NoCons—without balanced augmentation and artificially-generated consolidations and CNNBal/NoCons—with balanced augmentation but without artificially-generated consolidations. Segmentation results were assessed using Sørensen-Dice coefficient (SDC) and Hausdorff distance coefficient. Results Regarding the 187 MR test images without consolidations, the mean SDC of CNNUnbal/NoCons (92.1 ± 6% (mean ± standard deviation)) was significantly lower compared to CNNBal/NoCons (94.0 ± 5.3%, P = 0.0013) and CNNBal/Cons (94.3 ± 4.1%, P = 0.0001). No significant difference was found between SDC of CNNBal/Cons and CNNBal/NoCons (P = 0.54). For the 38 MR test images with consolidations, SDC of CNNUnbal/NoCons (89.0 ± 7.1%) was not significantly different compared to CNNBal/NoCons (90.2 ± 9.4%, P = 0.53). SDC of CNNBal/Cons (94.3 ± 3.7%) was significantly higher compared to CNNBal/NoCons (P = 0.0146) and CNNUnbal/NoCons (P = 0.001). Conclusions Expanding training datasets via balanced augmentation and artificially-generated consolidations improved the accuracy of CNNBal/Cons, especially in datasets with parenchymal consolidations. This is an important step towards a robust automated postprocessing of lung MRI datasets in clinical routine.