Miracle-dz/UniFAR-FTUs huggingface dataset:
Parental supervision as a protective family factor associated with conduct competence in adolescent males with alcohol dependent fathers.

The effects of parental alcohol dependence on children have been well documented in the literature. Parental alcohol dependence has been linked with negative developmental outcomes such as low self-esteem, depression, anxiety, difficulties in school and conduct problems in children (Johnson, 2001). However, some studies have indicated that there may be some protective factors in the environments of children of alcohol dependent parents (COAs) which promote positive developmental outcomes for such children (Menees & Sergin, 2000). The current study focused on parental supervision as a protective family factor that is linked to conduct competence in COAs. The participants’ perception of parental supervision was measured using the Parental Monitoring Assessment and their level of conduct competence was measured using the Weinberger Adjustment Inventory. The Weinberger Adjustment Inventory includes four domains of conduct competence: suppression of aggression, consideration of others, impulse control and responsibility. The main hypothesis of the study was that the participants’ perception of parental supervision correlates with their level of conduct competence with regards to the four domains. The sample included twenty adolescent males who were recruited through their fathers’ involvement in an alcohol rehabilitation program. The results indicated that the participants’ perceptions of parental supervision correlate with levels of conduct competence in the domains of consideration of others, there is no correlation between perception of parental supervision and conduct competence in the domain of responsibility, whilst there is a negative correlation between perception of parental supervision and conduct competence in the domains of suppression of aggression and impulse control.
History of ESL Pronunciation Teaching

This chapter tells the story of over 150 years in the teaching of English as a second language (ESL) pronunciation. An analysis of historical resources may reveal a reliable history of pronunciation teaching. A consistent theme within the historical record is that prior to the second half of the nineteenth century pronunciation received little attention in L2 classrooms. Beginning in the 1850s and continuing for the next 30 years, early innovators such as Berlitz, Gouin, Marcel, and Predergast were rejecting and transitioning away from classical approaches. A change that resulted in pronunciation teaching's considerably more consequential second wave was the formation in Paris during the period 1886-1889 of the International Phonetic Association. The 1950s-1970s coincide with a slow rise of attention to innovations in how to teach pronunciation. If we may speculate on the future of ESL pronunciation teaching, there is every reason to feel optimistic.
Comparative Staging of Embryo Development in Chicken, Turkey, Duck, Goose, Guinea Fowl, and Japanese Quail Assessed from Five Hours After Fertilization Through Seventy-Two Hours of Incubation

SUMMARY Normal tables of chicken embryo development are used to define specific stages of morphogenetic progression from the first cleavage divisions through hatching. Although established for the turkey and Pekin duck, the application of the normal tables of chicken embryo development to other birds of commercial and research importance needs be examined. Chicken, turkey, Japanese quail, and Pekin duck blastoderms from oviductal eggs showed differences in the rate of development that were inversely correlated with egg size. Oviposited eggs from these and additional species (goose, Muscovy and mule ducks, and Guinea fowl) were examined after 24 to 72 h of storage and at 6-h intervals up to 72 h of incubation. There was variation in the developmental stages of the blastoderm at the time of oviposition between and within the species and strains examined. Although it is recognized that the temporal rate of development will differ between different species and strains, the external features of any embryo in any given stage will be nearly identical.
Accounting narratives and impression management

This chapter focuses on impression management in accounting communication. Impression management entails the construction of a public impression by organisations with the intention to appeal to their audiences, including shareholders, stakeholders, the general public, and the media. If successful, it undermines the quality of financial reporting and capital misallocations may result. What is more, wider social and political consequences include unwarranted support by non-financial stakeholders or by society at large. Impression management is examined by reference to four perspectives: the economic, psychological, sociological, and critical. These variously conceptualise impression management as reporting bias, self-serving bias, symbolic management, and ideological bias.
Human Sterol 27-Hydroxylase (CYP27) Overexpressor Transgenic Mouse Model

CYP27-overexpressed transgenic mice were generated with the use of a human full-length CYP27 coding region cloned into a ubiquitous expression vector. Positive transgenic mice were identified by tail DNA genotyping and high fecal 27-hydroxycholesterol content. The levels of 27-hydroxycholesterol were found to be 3–5 times higher in the circulation and the tissues of the overexpressed mice when compared with littermate controls. There were no gross morphological differences between the overexpressed mice and their controls. Total cholesterol and triglyceride levels were not affected by overexpression of CYP27. Serum lathosterol was also normal, suggesting a normal rate of cholesterol synthesis. Serum levels of 7α-hydroxycholesterol were unaffected, suggesting a normal rate of bile acid formation in the pathway involving cholesterol 7α-hydroxylase. Biliary bile acid composition was slightly affected by CYP27 overexpression in female but not in male mice. Fecal levels of neutral steroids were slightly but significantly increased in overexpressor female mice but not in male mice. Levels of 24-hydroxycholesterol in the circulation were significantly reduced in the overexpressed mice, probably as a consequence of a recently described catabolic pathway involving CYP27. Combined with the results of our previous work on mice with a disruption of the CYP27gene, the present results suggest that the levels of 27-hydroxycholesterol are not of critical importance for cholesterol homeostasis in mice.
Detecting Blackholes and Volcanoes in Directed Networks

In this paper, we formulate a novel problem for finding blackhole and volcano patterns in a large directed graph. Specifically, a blackhole pattern is a group which is made of a set of nodes in a way such that there are only inlinks to this group from the rest nodes in the graph. In contrast, a volcano pattern is a group which only has outlinks to the rest nodes in the graph. Both patterns can be observed in real world. For instance, in a trading network, a blackhole pattern may represent a group of traders who are manipulating the market. In the paper, we first prove that the blackhole mining problem is a dual problem of finding volcanoes. Therefore, we focus on finding the blackhole patterns. Along this line, we design two pruning schemes to guide the blackhole finding process. In the first pruning scheme, we strategically prune the search space based on a set of pattern-size-independent pruning rules and develop an iBlackhole algorithm. The second pruning scheme follows a divide-and-conquer strategy to further exploit the pruning results from the first pruning scheme. Indeed, a target directed graphs can be divided into several disconnected subgraphs by the first pruning scheme, and thus the blackhole finding can be conducted in each disconnected subgraph rather than in a large graph. Based on these two pruning schemes, we also develop an iBlackhole-DC algorithm. Finally, experimental results on real-world data show that the iBlackhole-DC algorithm can be several orders of magnitude faster than the iBlackhole algorithm, which has a huge computational advantage over a brute-force method.
PathBLAST: a tool for alignment of protein interaction networks

PathBLAST is a network alignment and search tool for comparing protein interaction networks across species to identify protein pathways and complexes that have been conserved by evolution. The basic method searches for high-scoring alignments between pairs of protein interaction paths, for which proteins of the first path are paired with putative orthologs occurring in the same order in the second path. This technique discriminates between true- and false-positive interactions and allows for functional annotation of protein interaction pathways based on similarity to the network of another, well-characterized species. PathBLAST is now available at http://www.pathblast. org/ as a web-based query. In this implementation, the user specifies a short protein interaction path for query against a target protein-protein interaction network selected from a network database. PathBLAST returns a ranked list of matching paths from the target network along with a graphical view of these paths and the overlap among them. Target protein-protein interaction networks are currently available for Helicobacter pylori, Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster. Just as BLAST enables rapid comparison of protein sequences between genomes, tools such as PathBLAST are enabling comparative genomics at the network level.
Muscarinic Cholinergic Receptors in Rat Heart

The effects of thyroid status on muscarinic cholinergic receptors in the rat myocardium were investigated. The potent muscarinic antagonist PHlquinuclidinyl benzilate was used to identify muscarinic cholinergic receptors in rat heart particulate fractions from control, hypothyroid, and hyperthyroid rats. Thyroidectomy increased specific [3Hlquinuclidinyl benzilate binding to heart particulate fractions by about 60% as compared to euthyroid rat cardiac preparations. Administration of triiodothyronine to euthyroid rats decreased specific binding to muscarinic cholinergic receptors by about 20%. Scatchard analysis revealed that the cardiac particulate fraction from thyroidectomized rats contained 134 fmol of r3Hlquinuclidinyl benzilate binding sites per mg of protein, as compared with 85 fmollmg of protein found in the heart preparation of thyroidectomized rats chronically treated with triiodothyronine. The equilibrium dissociation constant for the interaction of receptors with quinuclidinyl benzilate was the same (1 nM) in the heart particulate fractions derived from these two groups of rats. The results of this study demonstrate that thyroid hormone can regulate the number of cardiac muscarinic cholinergic receptors. Thus, the parasympathetic nervous system may participate in the cardiovascular abnormalities in different thyroid states.
Studenters mål och motivation: En kvantitativ studie baserad på Expectancy Theory och Self-Determination Theory

This study is conducted with the help of 58 students in our Social Sciences departement examined the relationship between student valuations of academic outcomes and the perceived likelihood of these within the framework of Expectancy Theory. Furthermore, students current motivation was gauged using a SIMS test developed in accordance to Self- determination theory. The above mentioned tests were performed with an structured survey administered on campus. Goals were combined with perceived likelihood to produce products for each overarching goal. The following goals were examined: Economic goals, Self- realizing goals, Social status related goals, Love and family related goals and Academic goals. Bivariate correlational analysis was performed to examine the relationship between the products and various instances of motivation. The results found that students were mostly motivated by self-realizing goals, in addition, to academic goals and the most salient types of motivation for these were intrinsic motivation and identified regulation.
Usage of the T-norms and T-conorms in medical data classification

In this article, properties and usability of combined operator based on t-norms and t-conorms is studied in medical data classification. It is shown how this operator can be weighted with differential evolution and aggregated with a generalized mean, and what kinds of measures for comparison can be achieved from this procedure. New operators suitable for comparison measures are suggested, that are combination measures based on the use of Frank and Yu type of t-norms and t-conorms.
Should We Exclude Live Donor Liver Transplantation for Liver Transplant Recipients Requiring Mechanical Ventilation and Intensive Care Unit Care?

Background Patients with acute and chronic liver disease often require admission to intensive care unit (ICU) and mechanical ventilation support before liver transplantation (LT). Rapid disease progression and high mortality on LT waiting lists makes live donor LT (LDLT) an attractive option for this patient population. Methods During 2000 to 2011, all ICU-bound and mechanically ventilated patients receiving an LDLT (n = 7) were compared to patients receiving a deceased donor LT (DDLT) (n = 38). Results Both groups were comparable regarding length of pretransplant ICU stay (DDLT: 2 [1-31] days vs LDLT: 2 [1-8] days; P = 0.2), days under mechanical ventilation (DDLT: 2 [1-31] days vs LDLT: 2 [1-5] days; P = 0.2), pretransplant dialysis (DDLT: 45% vs LDLT: 43%; P = 1) and model for end-stage liver disease score (DDLT: 33 ± 8 vs LDLT: 33 ± 10; P = 0.911). Live donors median evaluation time was 24 hours (18-561 hours). As expected, median time on waiting list was significantly lower in the LDLT group (DDLT: 13 [0-1704] days vs LDLT: 10 [1-33] days; P = 0.008). Incidence of postoperative complications was numerically, albeit not significantly higher in the DDLT versus LDLT (68% vs 29%; P = 0.08). No difference was detected between LDLT and DDLT patients regarding 1-year (DDLT: 76% vs LDLT: 85%), 3-year (DDLT: 68% vs LDLT: 85%), and 5-year (DDLT: 68% vs LDLT: 85%) graft and patient survivals (P = 0.41). No severe donor complication occurred after live donation. Conclusions The LDLT may provide a faster access to transplantation and therefore, offers an alternative treatment option for critically ill patients requiring ICU care and mechanical ventilation support at the time of transplantation.
Amplification of TLK2 Induces Genomic Instability via Impairing the G2–M Checkpoint

Managing aggressive breast cancers with enhanced chromosomal instability (CIN) is a significant challenge in clinics. Previously, we described that a cell cycle–associated kinase called Tousled-like kinase 2 (TLK2) is frequently deregulated by genomic amplifications in aggressive estrogen receptor–positive (ER+) breast cancers. In this study, it was discovered that TLK2 amplification and overexpression mechanistically impair Chk1/2-induced DNA damage checkpoint signaling, leading to a G2–M checkpoint defect, delayed DNA repair process, and increased CIN. In addition, TLK2 overexpression modestly sensitizes breast cancer cells to DNA-damaging agents, such as irradiation or doxorubicin. To our knowledge, this is the first report linking TLK2 function to CIN, in contrast to the function of its paralog TLK1 as a guardian of genome stability. This finding yields new insight into the deregulated DNA damage pathway and increased genomic instability in aggressive ER+ breast cancers. Implications: Targeting TLK2 presents an attractive therapeutic strategy for the TLK2-amplified breast cancers that possess enhanced genomic instability and aggressiveness. Mol Cancer Res; 14(10); 920–7. ©2016 AACR.
Virtual Hellfire Hypervisor: Extending Hellfire Framework for embedded virtualization support

Virtualization of embedded systems has recently been in the spotlight especially because of the numerous advantages it can bring. Among these, the improvement of software design quality can be highlighted, since legacy software can be reused along with newer applications, easing newer and older systems' integration. Also, security concerned systems can enjoy the gains of virtualization: two Operating Systems (OS) can be used, namely an application OS and a security certified OS, both running on the same machine. Though virtualization can offer so many benefits, its use in embedded systems is still not as wide as it should or could be. The numerous constraints of embedded systems combined with suspicious thoughts whether virtualization overheads are prohibitive or not prevent its wide adoption. Thus, we present in this paper a methodology for an extension of the Hellfire Framework Project and the creation of the Virtual Hellfire Hypervisor — VHH. The Hellfire Framework already offers an integrated tool-flow in which Design Space Exploration (DSE), OS customization and static and dynamic application mapping are highly automated. Therefore, we show the potential benefits of integrating existing embedded systems tools, like the Hellfire Framework, to virtualization facilities and how this can impact in the overall system design quality.
Semantic dementia and pure anomia: Two varieties of progressive fluent aphasia

We compared the performance of one patient with typical semantic dementia (JL) with that of another patient (FM) who seemed to represent a different variety of progressive fluent aphasia. A series of neuropsychological and experimental investigations suggested that FM's anomia was not due to a loss of semantic knowledge or an impairment at the phonological level. These studies found the following: (1) Over time (3 years of longitudinal testing) FM had only a mild and stable impairment on tests of semantic memory, unlike other patients with semantic dementia, who often show rapid decline on such tests. (2) While FM performed at ceiling on tests of immediate single word repetition, she often lost the phonological form of words when a delay was introduced between her hearing the word and attempting to produce it. By contrast, her ability to perform word-picture matching tests was not affected by a timed delay, suggesting that she still had access to semantic information about the spoken word. (3) By using two gating experiments in which FM heard and had to identify incrementing fragments of concrete words, she showed near normal performance and minimal benefit from the provision of a semantic clue in the form of a picture of the spoken word. These results suggest that FM's deficits were due to a loss of communication between semantic memory and the phonological output lexicon: a case of progressive pure anomia rather than semantic dementia.
Differences and Developmental Changes in the Responsiveness of PNS Neurons to GDNF and Neurturin

We have studied the ability of GDNF and neurturin to promote the in vitro survival of populations of embryonic chicken parasympathetic, sympathetic, and sensory neurons. We show that these neurons are more responsive to one or other of these factors at particular stages of development. Whereas the parasympathetic neurons are more sensitive to neurturin at late embryonic stages, sympathetic neurons are more sensitive to neurturin at early stages. In contrast, sensory neurons of the nodose ganglion are more sensitive to GDNF throughout embryonic development. Using competitive RT/PCR, we measured the levels of mRNAs encoding GDNF and neurturin receptors in purified neurons. All neurons expressed Ret mRNA, which encodes the common receptor tyrosine kinase for GDNF and neurturin. Neurons that were more sensitive to GDNF expressed higher levels of GFRalpha-1 mRNA than GFRalpha-2 mRNA and neurons that were more sensitive to neurturin expressed higher levels of GFRalpha-2 mRNA than GFRalpha-1 mRNA. These results show that populations of PNS neurons differ markedly in their responsiveness to GDNF and neurturin at certain stages of the development and suggest that these differences are governed in part by the relative levels of expression of members of the GFRalpha family of GPI-linked receptors.
Efficient Bi-Iterative Method for Source Position and Propagation Speed Estimation Using TDOA Measurements

This paper develops an efficient bi-iterative source location and propagation speed estimation method utilizing time difference of arrival (TDOA) measurements. The source location and propagation speed estimation is a nonlinear problem due to the nonlinearity in the TDOA measurement equations. The newly developed bi-iterative method computes the source location and propagation speed alternately. The asymptotic convergence of the new bi-iterative method is theoretically analyzed. First-order perturbation analysis is applied to the newly developed solution to derive its bias and variance. The first-order analytical results show that the proposed method provides approximately unbiased source position and propagation speed estimates for low noise levels and the accuracy of these estimates approaches the Cramer-Rao lower bound (CRLB). The extension of the new bi-iterative method to the more general situation where the sensor locations are subject to random errors is also presented. Simulation studies are given to show the good performance of the proposed method.
Collective regret versus collective guilt: Different emotional reactions to historical atrocities

A distinction between guilt and regret in reactions to in-group atrocities is proposed. Four studies (total N = 1249) support the notion that guilt and regret are distinct emotional reactions. Whereas guilt is a self-focused, aversive emotional reaction following from appraisals of responsibility and associated with the intention to make amends, regret follows from an empathic victim perspective, is less aversive, and is more strongly associated with positive attitudes towards the victim groups and the intention to engage in intergroup contact. These findings suggest that less aversive emotions like regret are more likely to improve intergroup attitudes after a common history of conflict, but the aversive experience of guilt might be more potent in motivating reparations. Copyright © 2012 John Wiley & Sons, Ltd.
A Molecular Dynamics (MD) and Quantum Mechanics/Molecular Mechanics (QM/MM) Study on Ornithine Cyclodeaminase (OCD): A Tale of Two Iminiums

Ornithine cyclodeaminase (OCD) is an NAD+-dependent deaminase that is found in bacterial species such as Pseudomonas putida. Importantly, it catalyzes the direct conversion of the amino acid L-ornithine to L-proline. Using molecular dynamics (MD) and a hybrid quantum mechanics/molecular mechanics (QM/MM) method in the ONIOM formalism, the catalytic mechanism of OCD has been examined. The rate limiting step is calculated to be the initial step in the overall mechanism: hydride transfer from the L-ornithine’s Cα–H group to the NAD+ cofactor with concomitant formation of a Cα=NH2 + Schiff base with a barrier of 90.6 kJ mol−1. Importantly, no water is observed within the active site during the MD simulations suitably positioned to hydrolyze the Cα=NH2 + intermediate to form the corresponding carbonyl. Instead, the reaction proceeds via a non-hydrolytic mechanism involving direct nucleophilic attack of the δ-amine at the Cα-position. This is then followed by cleavage and loss of the α-NH2 group to give the Δ1-pyrroline-2-carboxylate that is subsequently reduced to L-proline.