Miracle-dz/UniFAR-FTUs huggingface dataset:
An incomplete contracts theory of information, technology and organization

Although there is good reason to expect that the growth of information work and information technology will significantly affect the trade-offs inherent in different structures for organizing work, the theoretical basis for these changes remains poorly understood. This paper seeks to address this gap by analyzing the incentive effects of different ownership arrangement in the spirit of the Grossman-Hart-Moore (GHM) incomplete contracts theory of the firm. A key departure from earlier approaches is the inclusion of a role for an "information asset", analogous to the GHM treatment of property. This approach highlights the organizational significance of information ownership and information technology. For instance, using this framework, one can determine when 1) informed workers are more likely to be owners than employees of firms, 2) increased flexibility of assets will facilitate decentralization, and 3) the need for centralized coordination will lead to centralized ownership. The framework developed sheds light on some of the empirical findings regarding the relationship between information technology and firm size and clarifies the relationship between coordination mechanisms and the optimal distribution of asset ownership. While many implications are still unexplored and untested, building on the incomplete contracts approach appears to be a promising avenue for the careful, methodical analysis of human organizations and the impact of new technologies.
Liberal national identity: Thinner than conservative, thicker than civic?

Many of the political debates in Europe call for the strengthening of a national identity that is, somewhat paradoxically, described in universal liberal terms. Yet previous research has not been able to tell to which extent these conceptions of national identity are indeed liberal. This is because we lack an analytical tool that allows liberal conceptions of national identity to be separated from, for example, conservative ones. There is also a pervasive yet questionable assumption that the more liberal a national identity is, the less it can per definition be truly national. This paper seeks to remedy this gap, by bridging the literature on these empirical trends of civic integration with the normative debates surrounding liberal nationalism. The result is a tripartite typology for the conceptions of national identity in conservative nationalism, liberal nationalism and constitutional patriotism, respectively. Each is specified along the following dimensions: (1) whether the sense of national belonging is defined by vertical or horizontal ties; (2) whether the national history is to be revered, taken as a starting point or critically scrutinised; (3) whether the legitimate place for the shared activity by which the national identity is upheld excludes the private or even the public non-political sphere; (4) whether we are asked to cultivate feelings of piety or loyalty to the homeland; and (5) whether or not the shared public culture of the nation is considered changeable and enforceable. Policy implications for individual rights, immigration and cultural minorities are also discussed.
Ustekinumab in Psoriasis Immunopathology with Emphasis on the Th17-IL23 Axis: A Primer

Psoriasis is a chronic relapsing immunoinflammatory dermatosis that is commonly associated with systemic comorbidities. The pathogenic importance of interleukin (IL)-12 and IL-23 is beyond doubt, as well as the involvement of T helper cells (Th)1 and Th17 cells. There is upregulation of the p40 subunit shared by IL-12 and IL-23 and of the IL-23 p19 subunit, but not an increased expression of the IL-12 p35 subunit. This indicates that IL-23 appears more involved than IL-12 in the pathogenesis of psoriatic plaques. Ustekinumab is a fully human monoclonal antibody of the immunoglobulin (Ig) G1 class targeting the p40 subunit common to both IL-12 and IL-23, thus inhibiting both IL-12 and IL-23 receptor-mediated signalling. Ustekinumab is part of the recent biologic therapies active in psoriasis, autoimmune arthritides, and inflammatory bowel diseases.
Growth and Fate of PSA-NCAM+ Precursors of the Postnatal Brain

Oligodendrocyte-type 2 astrocyte (O-2A) lineage cells are derived from multipotential stem cells of the developing CNS. Precursors of O-2A progenitors express the polysialylated (PSA) form of the neural cell adhesion molecule (NCAM) and are detected in neonatal rat brain glial cultures. It is unclear how such PSA-NCAM+ “pre-progenitors” are related to neural stem cells and whether they still have the potential to differentiate along several neural lineages. Here we isolated PSA-NCAM+ pre-progenitor cells from glial cultures by immunopanning and found that most of these cells expressed nestin and PDGF-receptor-α but not O-2A antigens. PSA-NCAM+ cells synthesized transcripts for fibroblast growth factor (FGF) receptors 1, 2, and 3 and responded to FGF2 by survival and proliferation, growing into large clusters resembling neural spheres. FGF2-induced proliferation of PSA-NCAM+ pre-progenitors was significantly enhanced by thyroid hormone (T3), which on its own did not increase cell survival or mitosis. After adhesion and withdrawal of the mitogen, spheres generated mostly oligodendrocytes and astrocytes but very rarely neurons. PSA-NCAM immunopanned cells grown in epidermal growth factor (EGF) also adopted a mostly glial fate after differentiation. In contrast, PSA-NCAM-negative cells and striatal neonatal stem cells, grown in EGF or FGF2, generated the three CNS cell types. Like neural stem cells, PSA-negative cells generated more oligodendrocytes and fewer neurons when expanded in FGF2 and T3. Thus emergence of PSA-NCAM at the surface of neonatal brain precursors coincides with their restriction to a glial fate. T3 modulates these events by enhancing PSA-NCAM+ pre-progenitor growth in FGF2 and favoring an oligodendrocyte fate.
Subharmonically injection locked 94 GHz MMIC HEMT oscillator using coplanar technology

A coplanar subharmonically injection locked VCO for 94 GHz with a tuning range of 4.5 GHz was developed, using 0.15 /spl mu/m AlGaAs-InGaAs-GaAs PM-HEMTs. A phase noise of -71 dBc/Hz at 1 MHz offset from the carrier was measured for the unlocked VCO. Using 3/sup rd/ subharmonic injection locking, a phase noise of -106 dBc/Hz at 1 MHz offset (-91 dBc/Hz at 100 KHz offset) for the locked VCO with a locking range of 1 GHz was achieved.
The rise of epitranscriptomic era: implications for cardiovascular disease

Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany; Department of Cardiology, Center of Internal Medicine, Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany; and German Center of Cardiovascular Research (Deutsches Zentrum für Herz-Kreislaufforschung; DZHK), Rhein-Main Partner Site, Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany
Possible role for nephron‐derived angiotensinogen in angiotensin‐II dependent hypertension

The role of intranephron angiotensinogen (AGT) in blood pressure (BP) regulation is not fully understood. Previous studies showed that proximal tubule‐specific overexpression of AGT increases BP, whereas proximal tubule‐specific deletion of AGT did not alter BP. The latter study may not have completely eliminated nephron AGT production; in addition, BP was only assessed on a normal salt diet. To evaluate this issue in greater detail, we developed mice with inducible nephron‐wide AGT deletion. Mice were generated which were hemizygous for the Pax8‐rtTA and LC‐1 transgenes and homozygous for loxP‐flanked AGT alleles to achieve nephron‐wide AGT disruption after doxycycline induction. Compared to controls, AGT knockout (KO) mice demonstrated markedly reduced renal AGT immunostaining, mRNA, and protein levels; unexpectedly AGT KO mice had reduced AGT mRNA levels in the liver along with 50% reduction in plasma AGT levels. BP was significantly lower in the AGT KO mice compared to controls fed a normal, low, or high Na+ intake, with the highest BP reduction on a low Na+ diet. Regardless of Na+ intake, AGT KO mice had higher plasma renin concentration (PRC) and markedly reduced urinary AGT levels compared to controls. Following angiotensin‐II (Ang‐II) infusion, AGT KO mice demonstrated an attenuated hypertensive response despite similar suppression of PRC in the two groups. Taken together, these data suggest that nephron‐derived AGT may be involved in Ang‐II‐dependent hypertension, however, a clear role for nephron‐derived AGT in physiological BP regulation remains to be determined.
An Empirical Investigation of the Influence of Context Parameters on Everyday Planning Activities

The purpose of the study is to explore the context, from the users’ perspective, in order to find relevant context parameters that can be useful in the development of the future context-aware technology. The goal is to find some of the context parameters relevant to the situated activity and investigate to what extent and in which way they influence the user in everyday planning activities.The method used in the study was based on scenario descriptions. A total of 41 participants reported how they would have acted in the different situations and they also rated how important they believed the different context factors were in the situations. Analyses were made to reveal relationships between context factors and service properties used by the participants in the scenarios.In the study several interesting relationships between context factors and the use of services were discovered. The level of urgency was in several situations considered to be important, and it was also found to have an impact on how the participants chose to communicate. The cost was introduced by the participants during the study. It seemed to be important; however, in situations with high urgency it became less important. The study revealed a potential relationship between the risk of disturbing the people in the vicinity and the effort to communicate quietly. Another interesting finding was the relationship between privacy and the choice of modality when communicating: voice-based services were avoided. Further, the importance of privacy and disturbance also appeared to have greater influence in non-anonymous situations than in anonymous.
Venous malformation: update on aetiopathogenesis, diagnosis and management

The aim of this review was to discuss the current knowledge on aetiopathogenesis, diagnosis and therapeutic management of venous malformations (VMs). VMs are slow-flow vascular anomalies. They are simple, sporadic or familial (cutaneomucosal VMs or glomuvenous malformations), combined (e.g. capillaro-venous and capillaro-lymphaticovenous malformations) or syndromic (Klippel–Trenaunay, blue rubber bleb naevus and Maffucci). Genetic studies have identified causes of familial forms and of 40% of sporadic VMs. Another diagnostic advancement is the identification of elevated d-dimer level as the first biomarker of VMs within vascular anomalies. Those associated with pain are often responsive to low-molecular-weight heparin, which should also be used to avoid disseminated intravascular coagulopathy secondary to intervention, especially if fibrinogen level is low. Finally, development of a modified sclerosing agent, ethylcellulose–ethanol, has improved therapy. It is efficient and safe, and widens indications for sclerotherapy to sensitive and dangerous areas such as hands, feet and periocular area.
Androgen Receptor Gene CAG Repeat Polymorphism Regulates the Metabolic Effects of Testosterone Replacement Therapy in Male Postsurgical Hypogonadotropic Hypogonadism

Aim. To evaluate the independent role of androgen receptor (AR) gene CAG repeat polymorphism on metabolic effects of testosterone replacement therapy (TRT) in male postsurgical hypogonadotropic hypogonadism, a condition frequently associated with hypopituitarism and in which the TRT-related metabolic effects are combined with those deriving from concomitant administration of metabolically active pituitary-function replacement therapies. Methods. 15 men affected by postsurgical hypogonadotropic hypogonadism were evaluated before and after TRT. Cardiovascular risk factors (CVRFs), pituitary-dependent hormones, and AR gene CAG repeat polymorphism were considered. Results. Testosterone, insulin-like growth factor 1 (IGF-1), and estradiol were the only hormones, which varied significantly between the two phases. All CVRFs significantly improved after TRT. The number of CAG triplets was positively and significantly correlated with all the variations (Δ-) of CVRFs (except for a significant negative correlation with Δ-high-density lipoprotein); the opposite occurred between the latter and Δ-testosterone. No correlation between Δ-IGF-1 or estradiol and Δ-CVRFs was found. At multiple linear regression, after correction for Δ-testosterone, nearly all the associations between the number of CAG triplets and Δ-CVRFs were confirmed. Conclusions. In male postsurgical hypogonadotropic hypogonadism, shorter AR gene CAG tract length seems to yield greater metabolic improvement after TRT, independently of the effects of concomitant pituitary-function replacement therapies.
Clustering Software Components for Component Reuse and Program Restructuring

Clustering Software Components for efficient component retrieval is gaining a significant practical importance in the field of software engineering from academic researchers and software industry. Clustering reduces the search space of components by grouping similar entities together thus ensuring reduced time complexity. Finding software components for efficient software reuse is one of the important problems gaining interest from researchers. In this Paper, we first define a similarity function and then give a generalized approach for clustering software components. A component may be a program module or any software document. The objective of component clustering is to form clusters containing high cohesive and low coupling components. Experiments were conducted with Reuters 21578 dataset by considering 70% of documents for training and 30% as test data.
HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse

The virological synapse (VS) is a tight adhesive junction between an HIV-infected cell and an uninfected target cell, across which virus can be efficiently transferred from cell to cell in the absence of cell-cell fusion. The VS has been postulated to resemble, in its morphology, the well-studied immunological synapse (IS). This review article discusses the structural similarities between IS and VS and the shared T cell receptor (TCR) signaling components that are found in the VS. However, the IS and the VS display distinct kinetics in disassembly and intracellular signaling events, possibly leading to different biological outcomes. Hence, HIV-1 exploits molecular components of IS and TCR signaling machinery to trigger unique changes in cellular morphology, migration, and activation that facilitate its transmission and cell-to-cell spread.
Correlates of accuracy in the assessment of psychiatric inpatients' risk of violence.

OBJECTIVE The authors evaluated characteristics of patients whom clinicians accurately assessed as being at high or low risk for violence and patients for whom clinicians overestimated or underestimated the risk. METHOD At admission, physicians estimated the probability that each of 226 psychiatric inpatients would physically attack someone during the first week of hospitalization. Nurses rated assaultive behavior in the hospital with the Overt Aggression Scale. Acute symptoms were rated with the Brief Psychiatric Rating Scale. RESULTS For the group as a whole, assessed levels of risk were substantially related to later physical aggression (sensitivity = 67%, specificity = 69%). Multinomial logit analysis showed that patients with psychotic disorders such as schizophrenia, organic psychotic conditions, and mania were more likely to be accurately assessed by clinicians as being at high risk (true positives) than to be true negatives or false positives. A recent history of violence was associated with higher estimated risk but did not distinguish true positives from false positives. An admission mental status characterized by low levels of hostility, uncooperativeness, and suspiciousness and high levels of depression, guilt, and anxiety differentiated true negative patients from others, but symptom profiles did not differ among true positives, false positives, and false negatives. Clinical judgments emphasizing gender and race/ethnicity were associated with predictive errors: nonwhite and male patients tended to be false positives. CONCLUSIONS While clinicians can accurately classify the potential for violence in the majority of patients at admission, systematic errors characterize inaccurate assessments of the risk. Awareness of these patterns may help improve assessment of the risk of violence in clinical practice.
Hyponatremia Associated With Exercise: Risk Factors and Pathogenesis

MONTAIN, S.J., M.N. SAWKA, and C.B. WENGER. Hyponatremia associated with exercise: risk factors and pathogenesis. Exerc. Sports Sci. Rev., Vol. 29, No. 3, pp. 113–117, 2001. Exercise-related hyponatremia is an infrequent but potentially life-threatening accompaniment of prolonged exercise. This condition results from sodium losses in sweat, excessive water intake, or both. We review the risk factors for development of this condition and discuss evidence that there is a population at increased risk of hyponatremia during prolonged exercise.
Eight Years of the Great Influenza Survey to Monitor Influenza-Like Illness in Flanders

In 2003, an internet-based monitoring system of influenza-like illness (ILI), the Great Influenza Survey (GIS), was initiated in Belgium. For the Flemish part of Belgium, we investigate the representativeness of the GIS population and assess the validity of the survey in terms of ILI incidence during eight influenza seasons (from 2003 through 2011). The validity is investigated by comparing estimated ILI incidences from the GIS with recorded incidences from two other monitoring systems, (i) the Belgian Sentinel Network and (ii) the Google Flu Trends, and by performing a risk factor analysis to investigate whether the risks on acquiring ILI in the GIS population are comparable with results in the literature. A random walk model of first order is used to estimate ILI incidence trends based on the GIS. Good to excellent correspondence is observed between the estimated ILI trends in the GIS and the recorded trends in the Sentinel Network and the Google Flu Trends. The results of the risk factor analysis are in line with the literature. In conclusion, the GIS is a useful additional surveillance network for ILI monitoring in Flanders. The advantages are the speed at which information is available and the fact that data is gathered directly in the community at an individual level.
Differential loss of embryonic globin genes during the radiation of placental mammals

The differential gain and loss of genes from homologous gene families represents an important source of functional variation among the genomes of different species. Differences in gene content between species are primarily attributable to lineage-specific gene gains via duplication and lineage-specific losses via deletion or inactivation. Here, we use a comparative genomic approach to investigate this process of gene turnover in the β-globin gene family of placental mammals. By analyzing genomic sequence data from representatives of each of the main superordinal clades of placental mammals, we were able to reconstruct pathways of gene family evolution during the basal radiation of this physiologically and morphologically diverse vertebrate group. Our analysis revealed that an initial expansion of the nonadult portion of the β-globin gene cluster in the ancestor of placental mammals was followed by the differential loss and retention of ancestral gene lineages, thereby generating variation in the complement of embryonic globin genes among contemporary species. The sorting of ε-, γ-, and η-globin gene lineages among the basal clades of placental mammals has produced species differences in the functional types of hemoglobin isoforms that can be synthesized during the course of embryonic development.
Partitioning in reinforcement learning

This paper addresses automatic partitioning in complex reinforcement learning tasks with multiple agents, without a priori domain knowledge regarding task structures. Partitioning a state/input space into multiple regions helps to exploit differential characteristics of regions and differential characteristics of agents, thus facilitating learning and reducing the complexity of agents especially when function approximators are used. We develop a method for optimizing the partitioning of the space through experience without the use of a priori domain knowledge. The method is experimentally tested and compared to a number of other algorithms. As expected, we found that the multi-agent method with automatic partitioning outperformed single-agent learning.
Recent and emerging theoretical frameworks for research on classroom learning : contributions and limitations

Over the past decade, a number of "new" conceptualizations of learning have entered the literature. These include various forms of constructivism such as "cognitive constructivism" and "social constructivism" as well as "sociocultural approaches" to learning. Unfortunately, differences "among" these approaches, in addition to differences "between" these approaches and more familiar cognitive psychological and information-processing frameworks have sometimes been blurred or misconstrued as those attempting to understand the new have incorporated aspects of these approaches into their previously held conceptualizations without adequately distinguishing subtle, but critical, differences. The purposes of this special issue are to shed greater light on differences among new and familiar approaches to understanding classroom learning and to highlight the contributions to and limitations of these approaches for understanding classroom learning. To achieve these purposes, contributors were asked to present key features as well as strengths and limitations of various frameworks for understanding classroom learning. These articles represent the current -- though often fluid -- thinking in the ongoing process of evolving knowledge about classroom learning.
Coronary risk factors in Kawasaki disease treated with additional gammaglobulin

Aims: To assess the hypothesis that an additional intravenous gammaglobulin (IVGG) infusion, if administered early, may prevent coronary artery lesions (CAL) in patients with Kawasaki disease (KD) who do not respond to initial IVGG therapy. Methods: Forty four KD patients (17 with CAL and 27 without CAL), treated with additional IVGG because of persistent or recrudescent fever after initial IVGG therapy, were studied. Main outcome measures were the presence of CAL by echocardiography and the number of febrile days before and after start of additional IVGG infusion (pre- and post-additional IVGG). Results: In univariate analyses, risk factors for CAL were the number of febrile days pre-additional IVGG, the number of febrile days post-additional IVGG, the number of days that initial IVGG was divided over, the white blood cell count pre- and post-additional IVGG, and the C reactive protein concentration pre-additional IVGG. In a multivariate analysis, the only independent risk factor was the number of febrile days pre-additional IVGG (⩾10 days; odds ratio 7.86; 95% CI 1.44 to 42.8; p = 0.02). Conclusions: Among KD patients with persistent or recrudescent fever after initial IVGG therapy, administration of additional IVGG before the first 10 febrile days was associated with a decreased prevalence of CAL, when compared with the prevalence in those who were retreated later. An additional IVGG infusion, if administered early, may prevent CAL in initial IVGG non-responders.