Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychosocial Stress in Nurses With Shift Work Schedule Is Associated With Functional Gastrointestinal Disorders

Background/Aims The aim of this study was to investigate the role of psychosocial problems and their associations with rotating shift work in the development of functional gastrointestinal disorders. Methods In this cross-sectional observation study, survey was administered to nurses and nurse assistants in a referral hospital. In addition to demographic questions, subjects were asked to complete the Rome III Questionnaire, Pittsburgh Sleep Quality Index and Rome III Psychosocial Alarm Questionnaire. Results Responses from 301 subjects were assessed. The overall prevalence of irritable bowel syndrome (IBS) and functional dyspepsia (FD) were 15.0% and 19.6%, respectively. Psychosocial alarms were prevalent in the nursing personnel (74.8% with alarm presence and 23.3% with serious condition) and were more frequent among rotating shift workers (84.7% vs. 74.5% for alarm presence and 28.1% vs. 13.3% for serious condition). The prevalence of both IBS and FD significantly increased with psychosocial risk. An independent risk factor for IBS was serious psychosocial alarm (adjusted odds ratio [aOR], 10.75; 95% confidence interval (CI), 1.30–88.99; P = 0.028). Serious psychosocial alarm was an independent risk factor for FD (aOR, 7.84; 95% CI, 1.98–31.02; P = 0.003). Marriage (aOR 0.30; 95% CI, 0.09–0.93; P = 0.037) was associated with the decreased risk of FD. Conclusions The high prevalence of psychosocial stress among nurses who work rotating shifts is associated with the development of functional gastrointestinal disorders.
9.3.2 Simulation‐Based Design Using SysML Part 1: A Parametrics Primer

OMG SysML™ is a modeling language for specifying, analyzing, designing, and verifying complex systems. It is a general‐purpose graphical modeling language with computer‐sensible semantics. This Part 1 paper and its Part 2 companion show how SysML supports simulation‐based design (SBD) via tutorial‐like examples. Our target audience is end users wanting to learn about SysML parametrics in general and its applications to engineering design and analysis in particular. We include background on the development of SysML parametrics that may also be useful for other stakeholders (e.g, vendors and researchers).
Pediatric Intensive Care Outcomes: Development of New Morbidities During Pediatric Critical Care*

Objective: To investigate significant new morbidities associated with pediatric critical care. Design: Randomly selected, prospective cohort. Setting: PICU patients from eight medical and cardiac PICUs. Patients: This was a randomly selected, prospective cohort of PICU patients from eight medical and cardiac PICUs. Measurements and Main Results: The main outcomes measures were hospital discharge functional status measured by Functional Status Scale scores and new morbidity defined as an increase in the Functional Status Scale of more than or equal to 3. Of the 5,017 patients, there were 242 new morbidities (4.8%), 99 PICU deaths (2.0%), and 120 hospital deaths (2.4%). Both morbidity and mortality rates differed (p < 0.001) among the sites. The worst functional status profile was on PICU discharge and improved on hospital discharge. On hospital discharge, the good category decreased from a baseline of 72% to 63%, mild abnormality increased from 10% to 15%, moderate abnormality status increased from 13% to 14%, severe status increased from 4% to 5%, and very severe was unchanged at 1%. The highest new morbidity rates were in the neurological diagnoses (7.3%), acquired cardiovascular disease (5.9%), cancer (5.3%), and congenital cardiovascular disease (4.9%). New morbidities occurred in all ages with more in those under 12 months. New morbidities involved all Functional Status Scale domains with the highest proportions involving respiratory, motor, and feeding dysfunction. Conclusions: The prevalence of new morbidity was 4.8%, twice the mortality rate, and occurred in essentially all types of patients, in relatively equal proportions, and involved all aspects of function. Compared with historical data, it is possible that pediatric critical care has exchanged improved mortality rates for increased morbidity rates.
Uso del Cuestionario de Capacidades y Dificultades (SDQ) como instrumento de cribado de trastornos psiquiátricos en la consulta de pediatría de Atención Primaria

Los trastornos de salud mental afectan a una parte importante de la población infantil. No son motivos habituales de consulta aún cuando están presentes, y el comportamiento de los pacientes es difícil de valorar dentro de su contexto sociocultural y evolutivo. Se diseñó un estudio con el fin de valorar la aplicabilidad del cuestionario SDQ como instrumento de cribado de trastornos de salud mental en una consulta de pediatría de atención primaria. Se incluyeron 108 niños pertenecientes a tres consultas distintas de la misma área sanitaria, entre los que se cumplimentó el cuestionario y se recogió información acerca de factores de riesgo. Quedaron excluidos del estudio los pacientes con diagnóstico psiquiátrico previo y/o que consultaran por este motivo. Del total de niños encuestados, 10 presentaron resultado alterado en el test (9,3%) y 9 fueron enviados para valoración al servicio de Psiquiatría Infantojuvenil. Presentaban factores de riesgo 3 pacientes. Se diagnosticó de TDAH a 3 de ellos (2,8%), ninguno con dichos factores. El cuestionario SDQ podría ser en la consulta de atención primaria un instrumento de cribado útil para sospechar trastornos mentales en la edad pediátrica y optimizar la derivación a las Unidades de Psiquiatría. Palabras clave: Salud mental; Trastorno comportamiento; Cribado; Test SDQ. ABSTRACT
Thrombolysis (Tissue Plasminogen Activator) in Stroke: A Medicolegal Quagmire

Background and Purpose— Despite the success of the 1995 National Institutes of Neurological Disorders and Stroke (NINDS) study using IV recombinant tissue plasminogen activator (tPA) within 3 hours in acute stroke and its subsequent FDA approval, there has been a reluctance to use tPA because of safety and efficacy issues with high incidence of intracerebral hemorrhage, and protocol violations. Summary of Review— The following cases will illustrate the increased number of malpractice lawsuits generated by the controversy of “standard of care” and illustrate and educate clinicians regarding specific issues and how to avoid: (A) Failure to use tPA (loss of chance) or to transfer, Reed versus Granbury Hospital (Texas): acute stroke victim taken to local hospital with tPA available only for cardiology. Wife subsequently transferred patient to nearby stroke center but no tPA given. Defendant verdict; (B) Stroke misdiagnosis (failure to diagnose, loss of chance), Mei versus Kaiser Permanente South (San Francisco, CA): acute stroke while driving with ambulance taking to local hospital. Symptoms were misdiagnosed and neurologist did not see her for 6 hours. Plaintiff verdict; (C) Bleeding complications of therapy/failure of informed consent, Harris versus Oak Valley Hospital (California): acute stroke and hypertension treated with tPA with subsequent development of intracerebral hemorrhage. Patient alleged that tPA should not have been given. Defense verdict; (D) Expert witness testimony, Wojcicki versus Caragher (Massachusetts): a prominent neurologist gave “false and misleading testimony” and the Court found that the neurologist perpetrated a “fraud on the Court” intentionally and deliberately misleading the Court and jury. Court sanctioned the neurologist $88 685; Ensink versus Mecosta County General Hospital (Michigan): neurological testimony (plaintiff expert) regarding potential benefit of using tPA during last available 1 hour of window was felt to be “speculative”. Defendant verdict. Conclusions— Neurologists, emergency room physicians and hospitals are at increased liability risk if they use or do not use tPA. Detailed documentation, informed consent or timely transfer should reduce threat of legal action.
Morphology and development of teeth and epidermal brushes in loricariid catfishes

Loricariidae or suckermouth armored catfishes are one of several aquatic taxa feeding on epilithic and epiphytic algae. Their upper and lower jaws bear exquisitely curved teeth, which usually are asymmetrically bicuspid. The enlarged lower lip carries papillae with keratinous unicellular epidermal brushes or unculi. Teeth, and probably unculi too, assist in scraping food off substrates. Their morphology, growth, and replacement is examined and compared among several loricariid species, using cleared and stained specimens, serial sections, and SEM. Apart from the general tooth form and crown shape, the anterior layer of soft tissue on the lower shaft region, present in several species, appears to be a specialization for enhancing the mobility of individual teeth when scraping on uneven surfaces. During early ontogeny, a transition from simple conical to mature tooth occurs. The first unculi appear together with the first teeth carrying a bicuspid crown, 2 days after the first exogenous feeding, but synchronous with the complete resorption of the yolk sac. J. Morphol. , 2007. © 2007 Wiley‐Liss, Inc.
Hesitation Phenomena in Spontaneous English Speech

[This paper reports an exploratory investigation of hesitation phenomena in spontaneously spoken English. Following a brief review of the literature bearing on such phenomena, a quantitative study of filled and unfilled pauses, repeats, and false starts in the speech of some twelve participants in a conference is described. Analysis in terms of both individual differences and linguistic distribution is made, and some psycholinguistic implications are drawn, particularly as to the nature of encoding units and their relative uncertainty. A distinction between non-chance statistical dependencies and all-or-nothing dependencies in linguistic methodology is made. ]
Multimodal assessment of visual attention using the Bethesda Eye & Attention Measure (BEAM)

ABSTRACT Introduction: Computerized cognitive tests measuring manual response time (RT) and errors are often used in the assessment of visual attention. Evidence suggests that saccadic RT and errors may also provide valuable information about attention. This study was conducted to examine a novel approach to multimodal assessment of visual attention incorporating concurrent measurements of saccadic eye movements and manual responses. Method: A computerized cognitive task, the Bethesda Eye & Attention Measure (BEAM) v.34, was designed to evaluate key attention networks through concurrent measurement of saccadic and manual RT and inhibition errors. Results from a community sample of n = 54 adults were analyzed to examine effects of BEAM attention cues on manual and saccadic RT and inhibition errors, internal reliability of BEAM metrics, relationships between parallel saccadic and manual metrics, and relationships of BEAM metrics to demographic characteristics. Results: Effects of BEAM attention cues (alerting, orienting, interference, gap, and no-go signals) were consistent with previous literature examining key attention processes. However, corresponding saccadic and manual measurements were weakly related to each other, and only manual measurements were related to estimated verbal intelligence or years of education. Conclusions: This study provides preliminary support for the feasibility of multimodal assessment of visual attention using the BEAM. Results suggest that BEAM saccadic and manual metrics provide divergent measurements. Additional research will be needed to obtain comprehensive normative data, to cross-validate BEAM measurements with other indicators of neural and cognitive function, and to evaluate the utility of these metrics within clinical populations of interest.
Biodiversity of the Symbiotic Bacteria Associated with Toxic Marine Dinoflagellate Alexandrium tamarense

Paralytic shellfish poisoning (PSP) toxins are potent neurotoxins mainly produced by dinoflagellates and being concentrated in bivalves through food web transfer. Increasing number of findings of toxin-producing bacteria in the cells of dinoflagellate such as Alexandriumtamarense supports the hypothesis of the bacterial origin of PSP toxins. Evidence that there are specific symbiosis bacterial taxa associated with the phytoplankton indicates the presence of specific selective mechanisms between them, and implies that the symbiosis bacteria have some vital function to the benefit of the dinoflagellates. Studies on the role of toxin-producing symbiosis bacteria in the marine ecosystem are considered to be becoming more important. Although toxigenic bacteria could be isolated from toxic dinoflagellates, it was not clearly proven whether the isolated bacterial strains based on culture-dependent manner and the corresponding intracellular bacteria were the same because of microbial unculturability. This paper aims to demonstrate the biodiversity of the symbiotic bacteria associated with toxic dinoflagellate A. tamarense using the culture-indepen- dent high-throughput pyrosequencing method, as well as the phylogenetic analysis based on 16S rDNA sequences of the symbiotic cultivable bacteria strains isolated from toxic Alexander tamarense.
The Relationship of Plantar Sensation with Standing Balance and Gait Post-Stroke

ii Table of Contents . iii List of Tables . vi List of Figures . vii Chapter 1 . 1 1 Introduction . 1 1.1 Stroke . 2 1.2 Gait after Stroke . 3 1.2.1 Gait Velocity after Stroke . 5 1.2.2 Gait Asymmetry after Stroke . 5 1.2.3 Post-Stroke Deficits Related to Decreased Velocity and Asymmetry . 7 1.3 Standing Balance after Stroke . 9 1.3.1 Post-Stroke Deficits Related to Decreased Standing Balance . 12 1.4 Somatosensation after stroke . 13 1.5 Role of plantar cutaneous sensation in gait and balance . 15 1.6 Vision as compensation for sensory loss . 18 1.7 Research Questions and Objectives . 19 Chapter 2 . 21 2 Methods . 21 2.1 BMFC Testing Protocol . 21 2.1.1 Clinical Measures . 22 2.1.2 Laboratory Measures . 25 2.2 Data Extraction . 27 2.3 Calculations and Measurements . 28 iv 2.3.1 Standing Balance: . 28 2.3.2 Over-ground gait: . 30 2.3.3 Classification by Plantar Sensation . 31 2.3. 4 Statistical Analysis . 32 Chapter 3 . 35 3 Results . 35 3.1 Participants . 35 3.2 Relationships between plantar sensation and balance and gait . 38 3.3 Research Objective Results . 42 3.3.1 Research Objective 1: Plantar sensation and standing balance control . 43 3.3.2 Research Objective 2: Plantar sensation and gait . 47 3.3.3 Research Objective 3: Plantar sensation, vision and control of posture . 49 Chapter 4 . 52 4 Discussion . 52 4.1 Deficits in Plantar Sensation Post-stroke . 53 4.2 Quiet Standing Balance and Gait Deficits Post Stroke . 54 4.3 The use of vision as a compensatory strategy for instability . 56 4.4 Research Objective 1: Plantar sensation and standing balance control . 57 4.5 Research Objective #2: Plantar Sensation and Gait . 58 4.6 Research Objective #3: Plantar sensation and compensation of vision for controlling upright posture . 62 4.7 Limitations . 63 4.8 Implications . 65 4.9 Future Directions . 66 4.10 Conclusion and Summary . 67 5 References . 68
Designing Conservation Relations in Layered Synthetic Biomolecular Networks

In Synthetic Biology, biomolecular networks are designed and constructed to perform specified tasks. Design strategies for these networks tend to center on tuning the parameters of mathematical models to achieve a specified behavior, and implementing these parameters experimentally. This design strategy often assumes a fixed network structure that defines the possible behaviors, which may be too restrictive for our purposes. This paper investigates the extent to which the state space of a synthetic network can also be designed and shaped by parametric tuning. We exploit timescale separation to implement new, nonlinear, tunable conservation relations that hold for all times beyond a fast transient. We demonstrate an application of this design strategy by flexibly constraining the possible behaviors of a gene regulatory network through the design of fast protein interactions.
A Clustering Genetic Algorithm For Extracting Rules From Multilayer Perceptrons Trained In Classification Problems

This paper deals with the task of using supervised neural networks in data mining applications. The proposed methodology makes use of a clustering genetic algorithm, which is applied in the hidden units activation space in order to extract rules from multilayer perceptions trained in classification problems. We illustrate the proposed method by means of two examples: Iris Plants Database and Meteorological dataset.
Efficient static buffering to guarantee throughput-optimal FPGA implementation of synchronous dataflow graphs

When designing DSP applications for implementation on field programmable gate arrays (FPGAs), it is often important to minimize consumption of limited FPGA resources while satisfying real-time performance constraints. In this paper, we develop efficient techniques to determine dataflow graph buffer sizes that guarantee throughput-optimal execution when mapping synchronous dataflow (SDF) representations of DSP applications onto FPGAs. Our techniques are based on a novel two-actor SDF graph Model (TASM), which efficiently captures the behavior and costs associated with SDF graph edges (flow-graph connections). With our proposed techniques, designers can automatically generate upper bounds on SDF graph buffer distributions that realize maximum achievable throughput performance for the corresponding applications. Furthermore, our proposed techinque is characterized by low polynomial time complexity, which is useful for rapid prototyping in DSP system design.
Efficient term proximity search with term-pair indexes

There has been a large amount of research on early termination techniques in web search and information retrieval. Such techniques return the top-k documents without scanning and evaluating the full inverted lists of the query terms. Thus, they can greatly improve query processing efficiency. However, only a limited amount of efficient top-k processing work considers the impact of term proximity, i.e., the distance between term occurrences in a document, which has recently been integrated into a number of retrieval models to improve effectiveness. In this paper, we propose new early termination techniques for efficient query processing for the case where term proximity is integrated into the retrieval model. We propose new index structures based on a term-pair index, and study new document retrieval strategies on the resulting indexes. We perform a detailed experimental evaluation on our new techniques and compare them with the existing approaches. Experimental results on large-scale data sets show that our techniques can significantly improve the efficiency of query processing.
Consistency checking of UML requirements

This paper discusses how to check consistency of UML requirements model which consists of a use case model and a conceptual class model with system constraints. Based on a given semantics, the requirements consistency can be defined and checked formally. The consistency among use cases and constraints are classified into five types. A system operation of interaction between actor and system is formally defined as a pair of pre and post conditions. An atomic use case is described as one system operation, and a composed use case may be defined as several system operations described by an activity diagram. Thus, each use case can also be modelled as a pair of pre and post conditions by composing the pre and post conditions of system operations by introducing a sequence composition operation. Requirement consistency can be logically checked based on the semantics. A simple library system is used as a case study to illustrate the feasibility of the method.
Effects of saponins of Panax notoginseng on sodium-potassium-adenosine triphosphatase and calcium-magnesium-adenosine triphosphatase.

Rat brain synaptosomal Na(+)-K(+)-ATPase was activated by Panax notoginseng (PNS, 0.1-1.0 mg.ml-1), fraction Rb1 (25-200 micrograms.ml-1), and fraction Rg1 (50-200 micrograms.ml-1). Activating rates were respectively 84-227%, 12-48%, and 12-22%. Results implied that Rb1 and Rg1 were not the major components of PNS, which were responsible for the activating effects. Ca(2+)-Mg(2+)-ATPase was inhibited by PNS (0.1-1.0 mg.ml-1) and Rb1 (100-200 micrograms.ml-1), but not by Rg1. It was proposed that PNS activated Na(+)-K(+)-ATPase, leading to a reduced Na+/Ca2+ exchange, a lowered intracellular Ca2+ level, and heart contractility.
Spectral envelope sampling and interpolation in linear predictive analysis of speech

In spite of its extensive use, speech analysis based on linear prediction (LP) is liable to various causes of inaccuracy. This paper presents a novel approach to improve the accuracy in the estimation of the voiced speech production model based on the LP method. The presented method uses interpolation between spectral points which are least influenced by artifacts in the spectral analysis and by noise in the signal. We show, on analyses of both synthetic and natural speech, that the averaged parabolic approximation between harmonic peaks of voiced speech spectrum reduces the sensitivity of the LP analysis to changes in the fundamental frequency Fo and to noise. The method is well suited for combination with the Spectral Transform LP method, previously proposed by the authors [1].
Intégrer les sites web dans les stratégies: concept et modèle

S’appuyant sur les principales avancees conceptuelles portant sur l’integration des TIC dans le domaine de la reflexion strategique et de la demarche marketing, ainsi que sur de nombreuses analyses terrain, les auteures ont defini un cadre conceptuel synthetique relatif a l’integration d’un site web dans l’organisation et la strategie commerciale d’une entreprise. Cette demarche les amene a proposer un modele d’analyse de cette integration qui permet aux managers de prendre la mesure des qualites ou des faiblesses de cette integration dans leur entreprise.
Regulation of Product Formation in Bacteroides xylanolyticus X5-1 by Interspecies Electron Transfer

Bacteroides xylanolyticus X5-1 was grown in pure culture and in mixed culture with Methanospirillum hungatei JF-1 under xylose limitation in the chemostat. In the pure culture, ethanol, acetate, CO2, and hydrogen were the products. In the mixed culture, acetate, CO2, and presumably hydrogen were the only products formed by B. xylanolyticus X5-1. The biomass yield of B. xylanolyticus X5-1 increased because of cocultivation. In cell extracts of the pure culture, both NAD- and NADP-dependent acetaldehyde dehydrogenase and ethanol dehydrogenase activities were found. In cell extracts of the mixed culture, activities of these enzymes were not detected. Inhibition of methanogenesis in the mixed culture by the addition of bromoethanosulfonic acid (BES) resulted in an accumulation of H2, ethanol, and formate. Immediately after the addition of BES, NAD-dependent acetaldehyde dehydrogenase and ethanol dehydrogenase activities were detected. After a short lag phase, a NADP-dependent ethanol dehydrogenase was also detectable. The induction of acetaldehyde dehydrogenase and ethanol dehydrogenase was inhibited by chloramphenicol, suggesting de novo synthesis of these enzymes. These results are consistent with a model in which the shift in product formation caused by interspecies electron transfer is regulated at the level of enzyme synthesis.