Miracle-dz/UniFAR-FTUs huggingface dataset:
Fatigue is a Brain-Derived Emotion that Regulates the Exercise Behavior to Ensure the Protection of Whole Body Homeostasis

An influential book written by A. Mosso in the late nineteenth century proposed that fatigue that “at first sight might appear an imperfection of our body, is on the contrary one of its most marvelous perfections. The fatigue increasing more rapidly than the amount of work done saves us from the injury which lesser sensibility would involve for the organism” so that “muscular fatigue also is at bottom an exhaustion of the nervous system. ” It has taken more than a century to confirm Mosso’s idea that both the brain and the muscles alter their function during exercise and that fatigue is predominantly an emotion, part of a complex regulation, the goal of which is to protect the body from harm. Mosso’s ideas were supplanted in the English literature by those of A. V. Hill who believed that fatigue was the result of biochemical changes in the exercising limb muscles – “peripheral fatigue” – to which the central nervous system makes no contribution. The past decade has witnessed the growing realization that this brainless model cannot explain exercise performance. This article traces the evolution of our modern understanding of how the CNS regulates exercise specifically to insure that each exercise bout terminates whilst homeostasis is retained in all bodily systems. The brain uses the symptoms of fatigue as key regulators to insure that the exercise is completed before harm develops. These sensations of fatigue are unique to each individual and are illusionary since their generation is largely independent of the real biological state of the athlete at the time they develop. The model predicts that attempts to understand fatigue and to explain superior human athletic performance purely on the basis of the body’s known physiological and metabolic responses to exercise must fail since subconscious and conscious mental decisions made by winners and losers, in both training and competition, are the ultimate determinants of both fatigue and athletic performance.
Classification, Subjectivities, and Personal Visibility

This article proposes extending the empirical sociological debate regarding the complex ways social classifications construct scenarios of subjectivity. Based on the case study of the Boarding School for the Gifted Disadvantaged in Israel, the article describes how a new cultural order created a new scenario of subjectivity (“gifted disadvantaged”) that had not been known before. This scenario was shaped in relation both to the ethnic classification in Israel, as well as to two social categories that were well-known in the educational field (“gifted” and “disadvantaged”). To understand the institutional dynamics involved in the construction of a new scenario of subjectivity, content analysis of the organizational documents that accompanied the founding of the school was carried out, and in-depth interviews with graduates of the school were conducted in order to understand how those who populate the new scenario experience their subjectivity years after its construction. The findings indicate a specific connection between classifications, subjectivity, and personal visibility. Specifically, the study reveals a number of phenomenological aspects that enhance the experience of visibility: the cognitive identification of two types of self; the experience of cognitive liminality; and the consciousness of having a subjectivity deserving of special nurturance.
Assessment of Meyer and Allen's three-component model of organizational Commitment in South Korea

J. P. Meyer and N. J. Allen's (N. J. Allen & J. P. Meyer, 1990; J. P. Meyer & N. J. Allen, 1991) 3-component model of organizationa l commitment was investigated with samples from 2 different organizations in South Korea. Data were collected by self-administered questionnaires and analyzed using covariance structure analysis. The results were mixed. Reliabilities of the Affective Commitment Scale (ACS) and the Normative Commitment Scale (NCS) were acceptable, whereas the reliability of the Continuance Commitment Scale (CCS) was low. The 3 scales had acceptable convergent validity, but the ACS and the NCS lacked discriminant validity. The construct validity of the ACS was supported, whereas the construct validities of the CCS and the NCS were questionable. Psychometric and conceptual problems were discussed, and suggestions for future research were advanced.
Brownian Dynamics 2.1 Introduction

The equations of physics are deterministic rather than stochastic in nature. Stochastic differential equations are used to approximate reality. They are introduced because systems are too complex to be described in detail, or simply because a detailed description is too difficult to handle. The stochastic aspect is introduced to model incomplete knowledge. Instead of describing a situation in full detail (a micro state) one describes possible situations, characterised by some coarse grained variable (defining a macro state). The most famous example of a stochastic differential equation is the Langevin equation which describes the highly irregular motion of a Brownian particle. The motion of a Brownian particle is the result of collisions with the many small solvent molecules surrounding it. In the ideal deterministic world the repetition of an experiment with identical initial conditions would give exactly the same final situation. This would require a full specification of the initial conditions of all the surrounding solvent molecules. In an experiment, however, when a Brownian particle is repeatedly released in a fluid, the trajectory of the particle will be different every time. Even if it where possible to give an identical initial condition to the Brownian particle in the different experiments, the initial conditions of the solvent molecules are beyond the control of the experimentalist. Variables which can not be controlled experimentally are usually not worth modelling in complete detail. A good, in some sense 'averaged' description is to be preferred in this case. Instead of describing all the fluid molecules it is common practice to introduce a stochastic Brownian force. None of the individual stochastic Brownian particles moves along exactly the same trajectory as the original deterministic particle. However, the stochastic modelling can be called successful when, after averaging over many of these typical trajectories, values of average quantities, such as the mean square displacement as a function of time, coincide with experimentally determined values. Brownian dynamics is a simulation method to numerically solve so-called stochastic differential equations. A stochastic variable represents a whole range of possible values all with a probability measure associated to it. The stochastic variable is quite an abstract 9
Clinical effect of point mutations in myelodysplastic syndromes.

BACKGROUND Myelodysplastic syndromes are clinically heterogeneous disorders characterized by clonal hematopoiesis, impaired differentiation, peripheral-blood cytopenias, and a risk of progression to acute myeloid leukemia. Somatic mutations may influence the clinical phenotype but are not included in current prognostic scoring systems. METHODS We used a combination of genomic approaches, including next-generation sequencing and mass spectrometry-based genotyping, to identify mutations in samples of bone marrow aspirate from 439 patients with myelodysplastic syndromes. We then examined whether the mutation status for each gene was associated with clinical variables, including specific cytopenias, the proportion of blasts, and overall survival. RESULTS We identified somatic mutations in 18 genes, including two, ETV6 and GNAS, that have not been reported to be mutated in patients with myelodysplastic syndromes. A total of 51% of all patients had at least one point mutation, including 52% of the patients with normal cytogenetics. Mutations in RUNX1, TP53, and NRAS were most strongly associated with severe thrombocytopenia (P<0.001 for all comparisons) and an increased proportion of bone marrow blasts (P<0.006 for all comparisons). In a multivariable Cox regression model, the presence of mutations in five genes retained independent prognostic significance: TP53 (hazard ratio for death from any cause, 2.48; 95% confidence interval [CI], 1.60 to 3.84), EZH2 (hazard ratio, 2.13; 95% CI, 1.36 to 3.33), ETV6 (hazard ratio, 2.04; 95% CI, 1.08 to 3.86), RUNX1 (hazard ratio, 1.47; 95% CI, 1.01 to 2.15), and ASXL1 (hazard ratio, 1.38; 95% CI, 1.00 to 1.89). CONCLUSIONS Somatic point mutations are common in myelodysplastic syndromes and are associated with specific clinical features. Mutations in TP53, EZH2, ETV6, RUNX1, and ASXL1 are predictors of poor overall survival in patients with myelodysplastic syndromes, independently of established risk factors. (Funded by the National Institutes of Health and others.).
Clozapine, agranulocytosis, and benign ethnic neutropenia

Current knowledge and clinical implications Clozapine is an atypical antipsychotic that is effective in treatment resistant schizophrenia.1 The National Institute for Health and Clinical Excellence (NICE) guidelines for schizophrenia specify that “in individuals with evidence of treatment resistant schizophrenia, clozapine should be introduced at the earliest opportunity”. 2 A severe adverse effect of clozapine that limits its more widespread use is agranulocytosis. Patients who are taking clozapine need to have their full blood counts (FBC) monitored regularly, and if the total white cell and/or neutrophil counts indicate agranulocytosis, clozapine prescription must be terminated. Among certain ethnic groups, a significant proportion of people have a low baseline neutrophil count. This is called benign ethnic neutropenia (BEN). This editorial looks at the important issues associated with agranulocytosis and BEN in patients receiving clozapine. Agranulocytosis occurs in about 1% of patients taking clozapine.3,4 Neutropenia is seen in about 3%. 4 The risk of both agranulocytosis and neutropenia is highest between 6 weeks and 18 weeks after starting clozapine treatment.4 Hence, in the United Kingdom and …
Hydrogel-Based 3D Model of Patient-Derived Prostate Xenograft Tumors Suitable for Drug Screening

The lack of effective therapies for bone metastatic prostate cancer (PCa) underscores the need for accurate models of the disease to enable the discovery of new therapeutic targets and to test drug sensitivities of individual tumors. To this end, the patient-derived xenograft (PDX) PCa model using immunocompromised mice was established to model the disease with greater fidelity than is possible with currently employed cell lines grown on tissue culture plastic. However, poorly adherent PDX tumor cells exhibit low viability in standard culture, making it difficult to manipulate these cells for subsequent controlled mechanistic studies. To overcome this challenge, we encapsulated PDX tumor cells within a three-dimensional hyaluronan-based hydrogel and demonstrated that the hydrogel maintains PDX cell viability with continued native androgen receptor expression. Furthermore, a differential sensitivity to docetaxel, a chemotherapeutic drug, was observed as compared to a traditional PCa cell line. These findings underscore the potential impact of this novel 3D PDX PCa model as a diagnostic platform for rapid drug evaluation and ultimately push personalized medicine toward clinical reality.
Characterization of infectious salmon anemia virus, an orthomyxo-like virus isolated from Atlantic salmon (Salmo salar L.)

Infectious salmon anemia (ISA) virus is the cause of infectious salmon anemia in farmed Atlantic salmon. The virus has been shown to contain RNA with structural characteristics similar to those of accepted members of the Orthomyxoviridae. Further biochemical, physiochemical, and morphological characterization of ISA virus was undertaken to clarify its taxonomic position. The virus was found to be sensitive to chloroform, heat, and low pH and agglutinated erythrocytes from fish. Erythrocytes from mammals or birds were not agglutinated. Receptor-destroying enzyme activity was detected, and the nature of this enzyme was suggested to be an acetylesterase. The buoyant density of the virus was 1.18 g/ml in sucrose and CsCl gradients. The maximum rate of virus replication was observed at 15 degrees C, while no virus was produced at 25 degrees C. Actinomycin D inhibited viral replication, and viral antigen was detected in nuclei by immunofluorescence. The addition of trypsin to the culture medium during virus replication had a beneficial effect on virus replication. ISA virus contains four major polypeptides with estimated molecular sizes of 71, 53, 43, and 24 kDa. Electron microscopy revealed structures closely resembling the nucleocapsids of influenza virus. Mushroom-shaped surface projections were a distinctive morphological feature, which differed from the rod-shaped hemagglutinin projections of the influenza viruses. The data reported here support the relationship of ISA virus to the Orthomyxoviridae, although ISA virus differs from influenza viruses in some morphological characteristics and in showing restricted hemagglutination, in different specificity of the receptor-destroying enzyme, in different polypeptide profile, in being unable to replicate at temperatures above 25 degrees C, and in host range.
Towards a nursing science of the unique

In this paper we attempt to counter the tendency for reflection and reflective practice to be marginalised by the growing dominance of evidence-based practice in nursing. We resist the assimilation of reflection into a hierarchy of evidence dominated by the findings from ‘hard science’, and argue instead for an alternative science of nursing based on the premise that nursing is a series of individual and unique encounters which cannot be described by a science of large numbers. The resulting ‘science of the unique’ is concerned with persons rather than people, with wet data from the clinical setting rather than dry data from the laboratory and clinical trial, and with the individual practice encounter as the site of reflexive research. In particular, we argue that the traditional concept of evidence from formal research is merely the starting point for the on-the-spot generation of reflective/reflexive evidence by nurses themselves as part of everyday practice.
Logistic regression of family data from retrospective study designs

We wish to study the effects of genetic and environmental factors on disease risk, using data from families ascertained because they contain multiple cases of the disease. To do so, we must account for the way participants were ascertained, and for within‐family correlations in both disease occurrences and covariates. We model the joint probability distribution of the covariates of ascertained family members, given family disease occurrence and pedigree structure. We describe two such covariate models: the random effects model and the marginal model. Both models assume a logistic form for the distribution of one person's covariates that involves a vector β of regression parameters. The components of β in the two models have different interpretations, and they differ in magnitude when the covariates are correlated within families. We describe ascertainment assumptions needed to estimate consistently the parameters βRE in the random effects model and the parameters βM in the marginal model. Under the ascertainment assumptions for the random effects model, we show that conditional logistic regression (CLR) of matched family data gives a consistent estimate ${\hat{\beta }}_{RE} $ for βRE and a consistent estimate for the covariance matrix of ${\hat{\beta }}_{RE} $. Under the ascertainment assumptions for the marginal model, we show that unconditional logistic regression (ULR) gives a consistent estimate for βM, and we give a consistent estimator for its covariance matrix. The random effects/CLR approach is simple to use and to interpret, but it can use data only from families containing both affected and unaffected members. The marginal/ULR approach uses data from all individuals, but its variance estimates require special computations. A C program to compute these variance estimates is available at http://www.stanford. edu/dept/HRP/epidemiology. We illustrate these pros and cons by application to data on the effects of parity on ovarian cancer risk in mother/daughter pairs, and use simulations to study the performance of the estimates. Genet Epidemiol 25:177–189, 2003. © 2003 Wiley‐Liss, Inc.
Longitudinal study of single‐word comprehension in semantic dementia: A comparison with primary progressive aphasia and Alzheimer's disease

Background: Although semantic dementia (SD) is characterised by a multimodal loss of semantic knowledge, it has been demonstrated that lexical‐semantic representations are not equally disrupted in SD and that some categories may be recognised better than others. Little is known, however, about the pattern of the category‐specific comprehension deficits in SD and whether it differs from that of other forms of progressive aphasias. Aims: This exploratory study aimed to investigate the evolution of category‐specific deficits of single‐word comprehension in progressive aphasias. Methods & Procedures: A total of 19 patients with a clinical diagnosis of SD, 25 patients with primary progressive aphasia with agrammatic and relatively nonfluent speech (PPA), and 25 patients with Alzheimer's disease (AD) with aphasia were studied longitudinally with the Western Aphasia Battery (WAB). The Auditory Word Recognition subtest of the WAB was utilised to assess comprehension of words derived from different semantic categories. Outcomes & Results: The analysis revealed that, over time, category‐specific deficits of single‐word comprehension were seen in all three groups of patients. Participants with SD as well as those with PPA and AD were impaired on both pointing to fingers and the right–left orientation task. However, patients with SD were the only group that showed defective recognition of their own body parts. Interestingly, individuals with SD had no difficulties identifying colours, letters, and numbers, even during the follow‐up testing. In addition, in all three groups the extent of category‐specific deficits was associated with the severity of aphasia. Conclusions: These results indicate that category‐specific deficits of single‐word comprehension are frequently seen not only in patients with SD but also in individuals with PPA or AD, and that the extent of these deficits is associated with the severity of aphasia. However, the pattern of these deficits is often different in these three forms of neurodegenerative conditions and more dissociations between semantic categories are observed as each of these diseases progresses.
An Examination of Park Preferences and Behaviors Among Urban Residents: The Role of Residential Location, Race, and Age

We examined the relationship between age, race and residential location with respect to four issues salient to public park agencies, (a) citizens' perceived need for additional park land; (b) preferences for the desired function of that park land (e.g., conservation vs. recreation); (c) preferences for the style of recreation (e.g., developed vs. naturebased recreation); and, (d) level of existing visitation to local parks. Data for this study was drawn from a general population of urbanites residing within a seven-mile radius of Cleveland Metroparks' newly opened Ohio & Erie Canal Reservation. Computer-assisted telephone interviewing (CATI) was used to collect data from respondents during an 8- to 10-minute interview. Eight hundred telephone interviews were completed in December, 2000, representing an overall response rate of 77% and an overall sampling error of - 3.5 %. Four logistic regression models were generated to test the relationships of interest. Results of the study suggested that while all three variables (race, age, and residential location) contributed significantly to the models, age was the strongest predictor of support/nonsupport for additional park land. Examination of park preferences revealed that older adults and Blacks were more likely to prefer recreation to conservation than younger adults and Whites. Race, however, was the strongest of these characteristics in terms of predictive power. Race had the strongest influence on the preference for type of recreation activity. When examining park visitation, older adults and Blacks were more likely to be nonvisitors.
A critical review of perfluorooctanoate and perfluorooctanesulfonate exposure and immunological health conditions in humans

Abstract Whether perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS), two widely used and biopersistent synthetic chemicals, are immunotoxic in humans is unclear. Accordingly, this article systematically and critically reviews the epidemiologic evidence on the association between exposure to PFOA and PFOS and various immune-related health conditions in humans. Twenty-four epidemiologic studies have reported associations of PFOA and/or PFOS with immune-related health conditions, including ten studies of immune biomarker levels or gene expression patterns, ten studies of atopic or allergic disorders, five studies of infectious diseases, four studies of vaccine responses, and five studies of chronic inflammatory or autoimmune conditions (with several studies evaluating multiple endpoints). Asthma, the most commonly studied condition, was evaluated in seven studies. With few, often methodologically limited studies of any particular health condition, generally inconsistent results, and an inability to exclude confounding, bias, or chance as an explanation for observed associations, the available epidemiologic evidence is insufficient to reach a conclusion about a causal relationship between exposure to PFOA and PFOS and any immune-related health condition in humans. When interpreting such studies, an immunodeficiency should not be presumed to exist when there is no evidence of a clinical abnormality. Large, prospective studies with repeated exposure assessment in independent populations are needed to confirm some suggestive associations with certain endpoints.
Does allopreening control avian ectoparasites?

For birds, the first line of defence against ectoparasites is preening. The effectiveness of self-preening for ectoparasite control is well known. By contrast, the ectoparasite control function of allopreening—in which one birds preens another—has not been rigorously tested. We infested captive pigeons with identical numbers of parasitic lice, and then compared rates of allopreening to the abundance of lice on the birds over time. We documented a negative relationship between rates of allopreening and the number of lice on birds. Moreover, we found that allopreening was a better predictor of louse abundance than self-preening. Our data suggest that allopreening may be a more important means of ectoparasite defence than self-preening when birds live in groups. Our results have important implications for the evolution of social behaviour.
Effect of isoflurane on monocyte adhesion molecule expression in human whole blood *

Background: Recruitment of monocytes to inflamed tissue is a crucial step in the acute inflammatory reaction. Adherence of monocytes to endothelial cells followed by transmigration depends on monocyte surface adhesion molecules, inflammatory cytokines and chemoattractant chemokines. In the present study, we determined the effect of isoflurane on monocyte adhesion receptor expression in vitro.