Miracle-dz/UniFAR-FTUs huggingface dataset:
Nucleation of From Precursor Films Using the Barium Fluoride Process

Coated-conductor applications of YBCO require YBCO layers with high and a thickness of several micrometers. The barium fluoride process offers a convenient way of depositing crack-free fluorinated precursor layers up to 5 microns thick. However, converting thick precursor layers into c-axis-oriented YBCO films is challenging due to extensive nucleation of random grains. In this paper we address this problem with both a theoret- ical and experimental analysis of YBCO nucleation. We utilized optical polarization contrast to observe YBCO nuclei imbedded in the precursor matrix. We observed that the nuclei density strongly depends on processing parameters, with the oxygen partial pres- sure being one of the strongest factors. During ex-situ processing the nuclei merge and form grains and the nuclei density is, there- fore, directly related to the grain size of YBCO film. It is desirable to have a small grain structure, since large grains do not connect well and the of such a film is low. However, attempts to increase the nuclei density also generates more randomly oriented grains. Therefore the optimization of ex-situ processing is essentially finding a balance between c-axis grain density and random grain content.
Prochlorococcus and Synechococcus have Evolved Different Adaptive Mechanisms to Cope with Light and UV Stress

Prochlorococcus and Synechococcus, which numerically dominate vast oceanic areas, are the two most abundant oxygenic phototrophs on Earth. Although they require solar energy for photosynthesis, excess light and associated high UV radiations can induce high levels of oxidative stress that may have deleterious effects on their growth and productivity. Here, we compared the photophysiologies of the model strains Prochlorococcus marinus PCC 9511 and Synechococcus sp. WH7803 grown under a bell-shaped light/dark cycle of high visible light supplemented or not with UV. Prochlorococcus exhibited a higher sensitivity to photoinactivation than Synechococcus under both conditions, as shown by a larger drop of photosystem II (PSII) quantum yield at noon and different diel patterns of the D1 protein pool. In the presence of UV, the PSII repair rate was significantly depressed at noon in Prochlorococcus compared to Synechococcus. Additionally, Prochlorococcus was more sensitive than Synechococcus to oxidative stress, as shown by the different degrees of PSII photoinactivation after addition of hydrogen peroxide. A transcriptional analysis also revealed dramatic discrepancies between the two organisms in the diel expression patterns of several genes involved notably in the biosynthesis and/or repair of photosystems, light-harvesting complexes, CO2 fixation as well as protection mechanisms against light, UV, and oxidative stress, which likely translate profound differences in their light-controlled regulation. Altogether our results suggest that while Synechococcus has developed efficient ways to cope with light and UV stress, Prochlorococcus cells seemingly survive stressful hours of the day by launching a minimal set of protection mechanisms and by temporarily bringing down several key metabolic processes. This study provides unprecedented insights into understanding the distinct depth distributions and dynamics of these two picocyanobacteria in the field.
Endoscopy in patients on antiplatelet or anticoagulant therapy, including direct oral anticoagulants: British Society of Gastroenterology (BSG) and European Society of Gastrointestinal Endoscopy (ESGE) guidelines

The risk of endoscopy in patients on antithrombotics depends on the risks of procedural haemorrhage versus thrombosis due to discontinuation of therapy. P2Y12 receptor antagonists (clopidogrel, prasugrel, ticagrelor) For low-risk endoscopic procedures we recommend continuing P2Y12 receptor antagonists as single or dual antiplatelet therapy (low quality evidence, strong recommendation); For high-risk endoscopic procedures in patients at low thrombotic risk, we recommend discontinuing P2Y12 receptor antagonists five days before the procedure (moderate quality evidence, strong recommendation). In patients on dual antiplatelet therapy, we suggest continuing aspirin (low quality evidence, weak recommendation). For high-risk endoscopic procedures in patients at high thrombotic risk, we recommend continuing aspirin and liaising with a cardiologist about the risk/benefit of discontinuation of P2Y12 receptor antagonists (high quality evidence, strong recommendation). Warfarin The advice for warfarin is fundamentally unchanged from British Society of Gastroenterology (BSG) 2008 guidance. Direct Oral Anticoagulants (DOAC) For low-risk endoscopic procedures we suggest omitting the morning dose of DOAC on the day of the procedure (very low quality evidence, weak recommendation); For high-risk endoscopic procedures, we recommend that the last dose of DOAC be taken ≥48 h before the procedure (very low quality evidence, strong recommendation). For patients on dabigatran with CrCl (or estimated glomerular filtration rate, eGFR) of 30–50 mL/min we recommend that the last dose of DOAC be taken 72 h before the procedure (very low quality evidence, strong recommendation). In any patient with rapidly deteriorating renal function a haematologist should be consulted (low quality evidence, strong recommendation).
National German Audit of Diagnosis, Treatment, and Teaching in Secondary Adrenal Insufficiency

Abstract Great heterogeneity seems to exist regarding diagnosis, therapy, and teaching of patients with secondary adrenal insufficiency (SAI) across Germany resulting in different diagnosis and treatment strategies. The aim of the work was to present the first national audit on diagnosis, treatment, and patient teaching of SAI reflecting common clinical practice in Germany. A self-designed questionnaire was sent via e-mail to all members of the German Endocrine Society (approx. 120 centers). Returned questionnaires (response rate 38.3%) were checked for duplicity of institutions and analyzed. Diagnostic testing focuses on those patients with relevant risk for adrenal insufficiency. Basal serum cortisol is mostly used as screening test. Short synacthen and CRH tests are the preferred confirmatory tests, however, cut-off values vary due to different assays used. Patients with radiation, second surgery, progressive disease or new symptoms are followed by serial re-testing. Perioperative management and frequency of postoperative re-evaluations differ among centers. Hydrocortisone is the preferred glucocorticoid for replacement therapy, but daily doses vary considerably (10–30 mg/day). Some centers perform hormone measurements for dose adjustment of glucocorticoid replacement therapy whereas others rely on clinical judgement. Patients’ teaching is done in 84% of centers, but only half of the centers include patients’ relatives. Homogeneity exists in patients’ teaching regarding intercurrent illnesses (fever, diarrhoea). Recommendations regarding dose adaptations in situations such as sport-activities, dental-procedures, or coughing are highly variable. This first national audit reveals great heterogeneity among German centers and could improve patients’ care in SAI, for example, by initiating new trials and developing clinical practice guidelines.
Immunolocalization of integrins in the human retina.

PURPOSE Integrins are cell surface proteins that participate in interactions between cells and with extracellular matrix. Binding of integrins to their ligands influences cell activities including proliferation, migration, and differentiation. Expression of integrin subunits from three different subfamilies were examined in human retina. METHODS Integrins were detected in frozen sections of two human retinas with an avidin-biotin-complex immunohistochemical technique, using nine different monoclonal antibodies specific for alpha 2, alpha 3, alpha 4, alpha 5, alpha 6, alpha v, beta 1, beta 2, and beta 3. One retina was from a patient who had conjunctival squamous cell carcinoma, and the other was from uninvolved regions of an eye with a choroidal melanoma. RESULTS All integrins tested were detectable in consistent patterns in two retinas. All except alpha 2 and alpha 4 were stained vibrantly in retinal and choroidal vessels. All alpha subunit staining of vessels showed overlap or close proximity to beta 1 staining. In addition to vessels, beta 1 was also present in the internal limiting membrane; alpha 2, alpha 3, alpha 4, alpha 5, and beta 2 were all found throughout much of the neural retina, albeit with distinctive staining patterns. Other than in association with vessels, alpha 6 and alpha v were not detected in neural retina, and beta 3 was only weakly detected in the nerve fiber layer; alpha 4 and beta 2 were expressed in the retinal pigment epithelium; beta 1 and beta 2 were strongly expressed in drusen present in one of the eyes. CONCLUSION Nine integrin subunits have been found to have unique distributions in adult human retina. An understanding of the distribution in normal retina can serve as a useful contrast to patterns of staining associated with retinal diseases.
Dopamine-dependent scaling of subthalamic gamma bursts with movement velocity in patients with Parkinson’s disease

Gamma synchronization increases during movement and scales with kinematic parameters. Here, disease-specific characteristics of this synchronization and the dopamine-dependence of its scaling in Parkinson’s disease are investigated. In 16 patients undergoing deep brain stimulation surgery, movements of different velocities revealed that subthalamic gamma power peaked in the sensorimotor part of the subthalamic nucleus, correlated positively with maximal velocity and negatively with symptom severity. These effects relied on movement-related bursts of transient synchrony in the gamma band. The gamma burst rate highly correlated with averaged power, increased gradually with larger movements and correlated with symptom severity. In the dopamine-depleted state, gamma power and burst rate significantly decreased, particularly when peak velocity was slower than ON medication. Burst amplitude and duration were unaffected by the medication state. We propose that insufficient recruitment of fast gamma bursts during movement may underlie bradykinesia as one of the cardinal symptoms in Parkinson’s disease.
On the Comparison of Deterministic and Probabilistic WCET Estimation Techniques

Timing validation is a critical step in the design of real-time systems, that requires the estimation of Worst-Case Execution Times (WCET) for tasks. A number of different methods have been proposed, such as Static Deterministic Timing Analysis (SDTA). The advent of Probabilistic Timing Analysis, both Measurement-Based (MBPTA) and Static Probabilistic Timing Analyses (SPTA), offers different design points between the tightness of WCET estimates, hardware that can be analyzed and the information needed from the user to carry out the analysis. The lack of comparison among those techniques makes complex the selection of the most appropriate one for a given system. This paper makes a first attempt towards comparing comprehensively SDTA, SPTA and MBPTA, qualitatively and quantitatively, under different cache configurations implementing LRU and random replacement. We identify strengths and limitations of each technique depending on the characteristics of the program under analysis and the hardware platform, thus providing users with guidance on which approach to choose depending on their target application and hardware platform.
Carbon nanotube field emission arrays

Abstract : This effort exploits the unique physical and electrical characteristics of carbon nanotubes (CNTs) for field emission applications. Carbon nanotube field emission devices are designed, fabricated, and tested. Two reliable CNT synthesis methods, microwave plasma enhanced chemical vapor deposition (MPE-CVD) and thermal chemical vapor deposition (T-CVD), are developed. The physical properties of the resulting CNTs are analyzed using Raman spectroscopy and Scanning electron microscopy (SEM) and then tested for field emission performance. The T-CVD grown CNTs are shown to have fewer growth defects, but suffer from less process control making integration into devices difficult without further process development. Field emission testing shows the T-CVD CNTs to be much better emitters, exceeding 13 mA/cm2 at an electric field of only 1.4 V/micrometer, while the best MPE-CVD CNTs only managed ~1 mA/cm2 at the much higher electric field of 4.56 V/micrometer. Two methods of device fabrication, conventional photolithography and nanosphere lithography, are developed and used to fabricate gated field emission arrays. Finite element analysis is used to optimize the gated array design to maximize the electric field strength. All fabrication steps are successfully demonstrated and prototype devices tested and compared to simple CNT carpet samples showing marked improvements by reducing electrostatic screening effects.
Speech based human emotion recognition using MFCC

Speech is a complex signal consisting of various information, such as information about the message to be communicated, speaker, language, region, emotions etc. Speech Processing is one of the important branches of digital signal processing and finds applications in Human computer interfaces, Telecommunication, Assistive technologies, Audio mining, Security and so on. Speech emotion recognition is important to have a natural interaction between human being and machine. In speech emotion recognition, emotional state of a speaker is extracted from his or her speech. The acoustic characteristic of the speech signal is Feature. Feature extraction is the process that extracts a small amount of data from the speech signal that can later be used to represent each speaker. Many feature extraction methods are available and Mel Frequency Cepstral Coefficient (MFCC) is the commonly used method. In this paper, speaker emotions are recognized using the data extracted from the speaker voice signal. Mel Frequency Cepstral Coefficient (MFCC) technique is used to recognize emotion of a speaker from their voice. The designed system was validated for Happy, sad and anger emotions and the efficiency was found to be about 80%.
Generalized time limited Gramian based model reduction

In this article, a generalized time limited Gramian based model reduction method is presented for unstable systems. The proposed approach is also applicable to a system if it has eigenvalues with opposite polarities and equal magnitude. The standard time-limited Gramians are extended for unstable systems by transforming the original system into a new system which involves the solution of two Riccati equations. The proposed approach is also illustrated by a numerical example.
Impact of inflammation on the biomarkers of iron status in a cross-sectional survey of Lao women and children

Anaemia is prevalent in South East Asia and Fe deficiency (ID) is considered to be the main cause, but the role of subclinical inflammation in the aetiology is uncertain. In the present study, we determined the influence of inflammation on the biomarkers of Fe status in women and children, and herein, we discuss the proportion of anaemia associated with ID. As part of the 2006 Lao People's Democratic Republic (The Lao PDR) National Nutrition Survey, blood collected from 482 young children and 816 non-pregnant women was analysed. Plasma ferritin, transferrin receptor (sTfR), Hb, C-reactive protein (CRP) and α-1-acid glycoprotein (AGP) concentrations were measured. ID was assessed using ferritin concentrations ( < 12 (children) or < 15 (adults) μg/l), sTfR concentrations (>8·3 mg/l) and body Fe stores (BIS < 0). Elevated CRP (>5 mg/l) and/or AGP (>1 g/l) concentrations were used to categorise inflammation status in order to correct the Fe biomarkers for inflammation. Inflammation was present in 14 % of adults and 43 % of children. Anaemia was present in 37·6 % of both women (Hb concentrations < 120 g/l) and children (Hb concentrations < 110 g/l). Correcting ferritin concentrations for inflammation increased the prevalence of ID from 24·3 to 26 % for women and from 18 to 21 % for children (P< 0·001 for both). Ferritin concentrations were more helpful in detecting ID than sTfR concentrations or BIS, but regression analysis found that sTfr concentrations explained more of the variance in Hb concentrations in both women (20 %) and children (17 %) than ferritin concentrations (5 and 1·4 %, respectively). Nevertheless, the total variance in Hb concentrations explained was only 26 and 18 % in women and children, respectively, and other factors may be more important than ID in contributing to anaemia in The Lao PDR.
On Two Combinatorial Optimization Problems in Graphs: Grid Domination and Robustness

In this thesis, we study two problems in combinatorial optimization, the dominating set problem and the robustness problem. In the first half of the thesis, we focus on the dominating set problem in grid graphs and present a distributed algorithm for finding near optimal dominating sets on grids. The dominating set problem is a well-studied mathematical problem in which the goal is to find a minimum size subset of vertices of a graph such that all vertices that are not in that set have a neighbor inside that set. We first provide a simpler proof for an existing centralized algorithm that constructs dominating sets on grids so that the size of the provided dominating set is upper-bounded by ⌈ (m+2)(n+2) 5 ⌉ for m× n grids and its difference from the optimal domination number of the grid is upper-bounded by five. We then design a distributed grid domination algorithm to locate mobile agents on a grid such that they constitute a dominating set for it. The basis for this algorithm is the centralized grid domination algorithm. We also generalize the centralized and distributed algorithms for the k-distance dominating set problem, where all grid vertices are within distance k of the vertices in the dominating set. In the second half of the thesis, we study the computational complexity of checking a graph property known as robustness. This property plays a key role in diffusion of information in networks. A graph G = (V,E) is r-robust if for all pairs of nonempty and disjoint subsets of its vertices A,B ⊂ V , at least one of the subsets has a vertex that has at least r neighbors outside its containing set. In the robustness problem, the goal is to find the largest value of r such that a graph G is r-robust. We show that this problem is coNP-complete. En route to showing this, we define some new problems, including the decision version of the robustness problem and its relaxed version in which B = V \A. We show these two problems are coNP-hard by showing that their complement problems are NP-hard.
Acoustic emission detection and position identification of transverse cracks in carbon fiber–reinforced plastic laminates by using a novel optical fiber ultrasonic sensing system

Utilizing optical fiber technique to structural health monitoring of composite materials is attracting attention recently due to the inherent advantages in optical fiber sensor. However, acoustic emission signals with low energy and high frequency from transverse cracks in carbon fiber–reinforced plastic laminates are difficult to be detected by normal optical techniques. In this work, we present a phase-shifted fiber Bragg grating balanced sensing system to detect acoustic emission signals generated in a carbon fiber–reinforced plastic laminate in a three-point bending test. We demonstrated that the phase-shifted fiber Bragg grating balanced sensing system with a broad bandwidth and high sensitivity can detect high-frequency, low-energy acoustic emission signals caused by transverse cracks. In our experiments, the transverse cracks were identified very well through the detected acoustic emission signals. The relationship between the strain and the acoustic emission signals, and the typical waveforms of the acoustic emission signals were investigated. Furthermore, accurate position identification using acoustic emission detection by the phase-shifted fiber Bragg grating sensor was demonstrated. All the results obtained from the phase-shifted fiber Bragg grating sensor were compared to the results obtained from commercial lead–zirconate–titanate acoustic emission sensors. We found that the phase-shifted fiber Bragg grating balanced sensing system performance was comparable to the commercial lead–zirconate–titanate acoustic emission sensors.
A Hybrid Location Privacy Protection Scheme in Big Data Environment

Location privacy has become a significant challenge of big data. Particularly, by the advantage of big data handling tools availability, huge location data can be managed and processed easily by an adversary to obtain user private information from Location-Based Services (LBS). So far, many methods have been proposed to preserve user location privacy for these services. Among them, dummy-based methods have various advantages in terms of implementation and low computation costs. However, they suffer from the spatiotemporal correlation issue when users submit consecutive requests. To solve this problem, a practical hybrid location privacy protection scheme is presented in this paper. The proposed method filters out the correlated fake location data (dummies) before submissions. Therefore, the adversary can not identify the user's real location. Evaluations and experiments show that our proposed filtering technique significantly improves the performance of existing dummy-based methods and enables them to effectively protect the user's location privacy in the environment of big data.
New insight into transglutaminase 2 and link to neurodegenerative diseases

Formation of toxic protein aggregates is a common feature and mainly contributes to the pathogenesis of neurodegenerative diseases (NDDs), which include amyotrophic lateral sclerosis (ALS), Alzheimer’s, Parkinson’s, Huntington’s, and prion diseases. The transglutaminase 2 (TG2) gene encodes a multifunctional enzyme, displaying four types of activity, such as transamidation, GTPase, protein disulfide isomerase, and protein kinase activities. Many studies demonstrated that the calcium-dependent transamidation activity of TG2 affects the formation of insoluble and toxic amyloid aggregates that mainly consisted of NDD-related proteins. So far, many important and NDD-related substrates of TG2 have been identified, including amlyoid-β, tau, α-synuclein, mutant huntingtin, and ALS-linked trans-activation response (TAR) DNA-binding protein 43. Recently, the formation of toxic inclusions mediated by several TG2 substrates were efficiently inhibited by TG2 inhibitors. Therefore, the development of highly specific TG2 inhibitors would be an important tool in alleviating the progression of TG2-related brain disorders. In this review, the authors discuss recent advances in TG2 biochemistry, several mechanisms of molecular regulation and pleotropic signaling functions, and the presumed role of TG2 in the progression of many NDDs.
Preserved brain metabolic activity at the age of 96 years

Loss of brain tissue becomes notable to cerebral magnetic resonance imaging (MRI) at age 30 years, and progresses more rapidly from mid 60s. The incidence of dementia increases exponentially with age, and is all too frequent in the oldest old (≥ 90 years of age), the fastest growing age group in many countries. However, brain pathology and cognitive decline are not inevitable, even at extremely old age (den Dunnen et al., 2008).