Miracle-dz/UniFAR-FTUs huggingface dataset:
Distribution of rabies virus, interferon and interferon-mediated enzymes in the brains of virus-infected rats.

The distribution of rabies virus, interferon and interferon-mediated enzymes, pppA(2'p5'A)n synthetase (2-5A synthetase) and poly(rI) . poly(rC)-Sepharose-bound protein kinase, was studied in different regions of the brains of rabies virus-infected rats. A broad range of virus infectivity was found in the brain stem, cerebellum, cortex, hippocampus and striatum. Similarly, the levels of interferon were variable (2500 to 60 000 units/mg protein in tissue extracts) in the different brain regions studied but were unrelated to the corresponding infectivities . The level of 2-5A synthetase and protein kinase was enhanced several-fold in the individual brain regions and the degree of such enhancement was correlated with the level of interferon.
Chloroplast Division

Chloroplasts are descendants of cyanobacteria and divide by binary fission. Several components of the division apparatus have been identified in the past several years and we are beginning to appreciate the plastid division process at a mechanistic level. In this review, we attempt to summarize the most recent developments in the field and assemble these observations into a working model of plastid division in plants.
Meniscus Shape of Molten Steel under Alternating Magnetic Field

The meniscus shape of molten steel under the alternating magnetic field was calculated in the two dimensional case by means of finite differential method. Penetration of magnetic flux line into the conductive charge was also taken into account. The detailed method of calculation was described and the validity of calculation was checked by theoretical analysis.The height of meniscus becomes large as the magnetic flux density and the frequency of the magnetic field increases. And further, it is cleared that the meniscus shape, under the magnetic field caused by the short coil, is more favorable than the uniform magnetic field or the one which is caused by the long coil, in terms of supporting meniscus.
Effect of hydroalcoholic extract of leaves of Colocasia esculenta on marble-burying behavior in mice: Implications for obsessive–compulsive disorder

Abstract Context: Over the past decades, the inhibition of spontaneous burying of glass marbles by mice has been used as an index of anxiolytic drug action in the so-called marble-burying test. Although Colocasia esculenta Linn. (Araceae), commonly known as elephant ear (English), possesses several medicinal properties, little is known for its use in neurological activity. Objective: The current research evaluated the anti-obsessive–compulsive disorder (anti-compulsive) activity of the hydroalcoholic extract of leaves of Colocasia esculenta (HECE) for the first time using the marble-burying behavior test in mice. Materials and methods: In the present study, the effect of HECE (25 and 50 mg/kg) intraperitoneally (i.p.) was examined using the marble-burying behavior test, which is an animal model of obsessive compulsive disorder (OCD), using Swiss albino mice. Results and discussion: The acute toxicity studies showed that the LD50 value of the HECE in mice was 1000 mg/kg by i.p. route. The effect of HECE (25 and 50 mg/kg, i.p.) was characterized by significant reduction in the number of buried marbles as compared with the control group (p < 0.001). The effect of HECE was comparable with that of fluoxetine (5 mg/kg, i.p.) – a reference standard drug used in the treatment of obsessive–compulsive disorder (p < 0.001). Fluoxetine and HECE do not produce any overt motor dysfunction. Conclusions: The results of the study for the first time show that the plant possesses anti-compulsive activity, confirming the traditional claims. Future research should focus on the identification and the anti-compulsive activity of the constituents from this plant.
Gazor: a gaze aware industrial IoT-based instructor

While the amount of applications being based on the Internet of Things is ever increasing, few consider proper - human cognition and attention aware - interaction between IoT and their users. In this paper, we demonstrate Gazor an IoT hardware and software platform which makes use of inherent human behavior to instruct a worker about an industrial assembly process, by providing an attention steering stimulus, where users need to pick up parts or place them, and a retention supporting peripheral display.
Morphological PDEs on graphs for filtering and inpainting of point clouds

In this paper, we propose an adaptation of morphological Partial Differential Equations (PDEs) on graphs using the framework of Partial difference Equations (PdEs). This enables to define adaptive morphological operators on graphs. We then show how these operators can be used for interpolation and filtering of raw point clouds. To enable a patch-based processing of point clouds, we also show how a weighted graph based on patches can be associated with a point cloud. Finally, we present applications in cultural heritage1.
The BBC micro : bit Coded by Microsoft Touch Develop

The chance to influence the lives of a million children comes once in a generation. With the partnership between the BBC and several technology companies, a small device, the BBC micro:bit will be given to a million children in the UK in 2016. Moreover, using the micro:bit will be part of the curriculum. This demo describes the BBC micro:bit together with its software platform, based on Microsoft's Touch Develop. The demo will illustrate the architecture of the micro:bit and the software engineering hurdles that had to be overcome to enable it to be used by children. Evaluation of studies of the software platform are available and early anecdotal evidence of the hardware. A video about the micro:bit is available at aka.ms/bbcmicrobit.
P‐170: Advanced Photo Spacer Technology for Large‐sized TFT‐LCD

During ODF(one drop filling) process technology, the height, volume and elastic recovery ratio of photo spacer(PS) are very critical factors for liquid crystal injection process window and cell gap in the assembly of TTFT‐LCD panel module. Experimental results showed that photo spacer height is very sensitive to any pre‐layer photo resist residue and film thickness deviation. In the ODF process, liquid crystal injection window is related to photo spacer height, volume and elastic recovery ratio.
Class III Phosphatidylinositol 4-Kinase Alpha and Beta Are Novel Host Factor Regulators of Hepatitis C Virus Replication

ABSTRACT Host factor pathways are known to be essential for hepatitis C virus (HCV) infection and replication in human liver cells. To search for novel host factor proteins required for HCV replication, we screened a subgenomic genotype 1b replicon cell line (Luc-1b) with a kinome and druggable collection of 20,779 siRNAs. We identified and validated several enzymes required for HCV replication, including class III phosphatidylinositol 4-kinases (PI4KA and PI4KB), carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD), and mevalonate (diphospho) decarboxylase. Knockdown of PI4KA could inhibit the replication and/or HCV RNA levels of the two subgenomic genotype 1b clones (SG-1b and Luc-1b), two subgenomic genotype 1a clones (SG-1a and Luc-1a), JFH-1 genotype 2a infectious virus (JFH1-2a), and the genomic genotype 1a (FL-1a) replicon. In contrast, PI4KB knockdown inhibited replication and/or HCV RNA levels of Luc-1b, SG-1b, and Luc-1a replicons. The small molecule inhibitor, PIK93, was found to block subgenomic genotype 1b (Luc-1b), subgenomic genotype 1a (Luc-1a), and genomic genotype 2a (JFH1-2a) infectious virus replication in the nanomolar range. PIK93 was characterized by using quantitative chemical proteomics and in vitro biochemical assays to demonstrate PIK93 is a bone fide PI4KA and PI4KB inhibitor. Our data demonstrate that genetic or pharmacological modulation of PI4KA and PI4KB inhibits multiple genotypes of HCV and represents a novel druggable class of therapeutic targets for HCV infection.
Human chondrocyte expression of growth-arrest-specific gene 6 and the tyrosine kinase receptor axl: potential role in autocrine signaling in cartilage.

OBJECTIVE To determine if human articular chondrocytes express the axl tyrosine kinase receptor and its ligand Gas-6, a protein product of growth-arrest-specific gene 6, and to determine if Gas-6 and axl function in the regulation of chondrocyte growth and survival. METHODS The presence of Gas-6 and axl was examined in situ in human articular cartilage by immunohistochemistry and in vitro in cell culture studies using primary human chondrocytes and immortalized human chondrocytes. The ability of recombinant Gas-6 to mediate adhesion of chondrocytes and to stimulate chondrocyte axl phosphorylation was determined. Studies of the role of Gas-6 and axl in cell proliferation and survival were also performed. RESULTS Both Gas-6 and axl were detected in cartilage by immunohistochemical staining. Gas-6 and axl messenger RNA (mRNA) and protein were also detected in cultures of primary and immortalized human chondrocytes. Compared with cells cultured in medium containing 10% serum, Gas-6 mRNA levels were increased in immortalized chondrocytes cultured in serum-free medium, while axl expression decreased. Chondrocytes attached to Gas-6-coated plastic, and the attachment was blocked by a soluble Ig fusion protein containing the axl extracellular domain. Recombinant human Gas-6 and serum-free conditioned medium from primary and immortalized human chondrocyte cultures stimulated chondrocyte axl tyrosine phosphorylation. A mitogenic effect was noted both when immortalized chondrocytes were stimulated with recombinant Gas-6 or when they were made to overexpress axl by transfection. Addition of recombinant Gas-6 to serum-free medium resulted in increased survival of primary chondrocytes cultured at low density in agarose. CONCLUSION These findings present evidence for an autocrine signaling pathway in cartilage involving Gas-6 and the axl tyrosine kinase adhesion receptor. Stimulation of axl by Gas-6 may play an important role in the control of chondrocyte growth and survival.
3-D Controlled Source Electromagnetic (CSEM) interferometry by multi-dimensional deconvolution

SUMMARY Controlled Source Electromagnetic (CSEM) is an important technique in hydrocarbon exploration because it uses the large contrast in electrical resistivity to distinguish between water and hydrocarbons. In a shallow sea environment, the airwave that is refracted from the air-water interface dominates the recorded signal at large offsets. Therefore, the hydrocarbon detection ability of the CSEM is weakened because the airwave is independent of the properties of the subsurface. For a layered earth model, we apply multi-dimensionaldeconvolution interferometry to synthetic 3D CSEM data and estimate the reflection response of the subsurface. The difference in the models with and without a resistive layer is significantly increased by the employed interferometric analysis. However, the required receiver spacing is much denser than that of current CSEM surveys. In order to apply this technique to a field survey, we are currently working on how to relax the required receiver criterion for this technique.
Sprint Exercise Performance: Does Metabolic Power Matter?

Prevailing physiological paradigms explain both sprint and endurance exercise performance in terms of the availability of metabolic energy. However, for all-out efforts of 60 s or less, the prevailing view is no longer viable. Contemporary evidence indicates that sprinting performance is determined by musculoskeletal force application, with a duration dependency explained by the intrinsically rapid rates at which skeletal muscle fatigues in vivo.
Applying hierarchical fuzzy systems to predict unplanned feeder outages in the Yazd

Weather conditions and various phenomena cause unplanned power outages. These factors should be identified in a proper time and therefore prevent the occurrence of power outages. The aim of this paper is to provide a system that predicts unplanned outages before they occur to take necessary actions for no outage, power restoration and reduce costs. Based on the primary experiments, weather data for two days ago and historical outage are used as input of the proposed system. First, pre-processing is performed on data and outages factors identified and then hierarchical fuzzy system is used. In the first level, four features obtained from data mining are considered as input of a Mamdani fuzzy system. The outputs of this fuzzy system with fifth feature obtained from data mining would be inputs of the second fuzzy system. The System's output would be next day's outage or no outage prediction. At the end, system is evaluated with Yazd and Meybod regional data and accuracy 94.23 is obtained.
Protein Kinase C- (cid:2) Phosphorylation of Speciﬁc Serines in the Connecting Segment of the (cid:3) 4 Integrin Regulates the Dynamics of Type II Hemidesmosomes

Although the regulation of hemidesmosome dynamics during processes such as epithelial migration, wound healing, and carcinoma invasion is important, the mechanisms involved are poorly understood. The integrin (cid:1) 6 (cid:2) 4 is an essential component of the hemidesmosome and a target of such regulation. Epidermal growth factor (EGF) can induce hemidesmosome disassembly by a mechanism that involves serine phosphorylation of the (cid:2) 4 integrin subunit. Using a combination of biochemical and mutational analyses, we demonstrate that EGF induces the phosphorylation of three speciﬁc serine residues (S 1356 , S 1360 , and S 1364 ) located within the connecting segment of the (cid:2) 4 subunit and that phosphorylation on these residues accounts for the bulk of (cid:2) 4 phosphorylation stimulated by EGF. Importantly, phosphorylation of these serines is critical for the ability of EGF to disrupt hemidesmosomes. Using COS-7 cells, which assemble hemidesmosomes type II upon exogenous expression of the (cid:1) 6 (cid:2) 4 integrin, we observed that expression of a (cid:2) 4 construct containing Ser 3 Ala mutations of S 1356 , S 1360 , and S 1364 reduced the ability of EGF to disrupt hemidesmosomes and that this effect appears to involve cooperation among these phosphorylation sites. Moreover, expression of Ser 3 Asp mutants that mimic constitutive phosphorylation reduced hemidesmosome formation. Protein kinase C- (cid:1) (PKC- (cid:1) ) is the kinase responsible for phosphorylating at least two of these serines, based on in vitro kinase assays, peptide mapping, and mutational analysis. Together, these results highlight the importance of serine phosphorylation in regulating type II hemidesmosome disassembly, implicate a cluster of serine residues within the connecting segment of (cid:2) 4, and argue for a key role for PKC- (cid:1) in regulating these structures.
Z2-FET used as 1-transistor high-speed DRAM

We have recently demonstrated a new device named Z<sup>2</sup>-FET (zero subthreshold swing and zero impact ionization) and proposed it as a 1-transistor DRAM. The device is built on an FD-SOI substrate and operates by feedback between carrier flows and injection barriers. We now present additional results obtained from extensive experiments and simulations. Experimentally, the I<sub>ON</sub>/I<sub>OFF</sub> ratio exceeds 10<sup>9</sup> and supply voltage (V<sub>DD</sub>) scales down to 1.1 V with the DRAM retention time as high as 0.15 s at 75°C. In simulation, the access time reaches below 1 ns and the Z<sup>2</sup>-FET can be scaled down to 30 nm. We also discuss various operation modes.
Oiling the Brain: A Review of Randomized Controlled Trials of Omega-3 Fatty Acids in Psychopathology across the Lifespan

Around one in four people suffer from mental illness at some stage in their lifetime. There is increasing awareness of the importance of nutrition, particularly omega-3 polyunsaturated fatty acids (n-3 PUFA), for optimal brain development and function. Hence in recent decades, researchers have explored effects of n-3 PUFA on mental health problems over the lifespan, from developmental disorders in childhood, to depression, aggression, and schizophrenia in adulthood, and cognitive decline, dementia and Alzheimer’s disease in late adulthood. This review provides an updated overview of the published and the registered clinical trials that investigate effects of n-3 PUFA supplementation on mental health and behavior, highlighting methodological differences and issues.
Quality of life and psychiatric morbidity in panic disorder and generalized anxiety disorder.

OBJECTIVE This report examines the impact of panic disorder and/or generalized anxiety disorder on quality of life and the implications of these findings on nosological categories. METHOD A total of 357 subjects with a current episode of panic disorder and/or generalized anxiety disorder were diagnosed according to DSM-III-R criteria, using structured clinical interviews, as part of a prospective, naturalistic, longitudinal, multicenter study of a clinical population with anxiety disorders. RESULTS There was a high degree of coexistence of anxiety disorders and major depressive disorder. Subjects with generalized anxiety disorder almost universally had other disorders, were the most likely to have at least one other anxiety disorder or major depressive disorder at intake, had the earliest age at onset, and had the worst emotional health rating. Subjects with panic disorder without agoraphobia had the most likelihood of a history of alcohol abuse. Nine percent of the subjects had a history of suicide attempts or gestures. CONCLUSIONS The subjects showed significant impairment in quality of life. The highly frequent coexistence of other anxiety disorders with generalized anxiety disorder and the overall lack of differences on many quality of life measures raise questions of nosology, particularly for generalized anxiety disorder.
Children's and parents' perspectives about activity performance and participation after spinal cord injury: initial development of a patient-reported outcome measure.

OBJECTIVE To report on a cognitive testing study on newly constructed items designed to evaluate client-reported outcomes of activity performance and participation after spinal cord injury (SCI). METHOD Thirty-three children with SCI and 13 caregivers participated in cognitive testing interviews. Open-ended questions were used to gain a better understanding of activity performance and participation. The interviews were transcribed verbatim. A thematic analysis was carried out independently by 2 researchers, and key sentences and phrases from both analyses were merged. RESULTS Four themes were defined: (1) apprehension related to activity performance and participation, (2) reference point, (3) missing out, and (4) autonomy. CONCLUSION Insight into children's and caregivers' perspectives provided important information that helped refine the wording of test items and response scales. The theme of autonomy provided a stronger catalyst to solidify items for both child- and parent-reported outcomes. This study further validated the complexity of the construct of participation.
Television and music video exposure and adolescent alcohol use while going out.

AIMS To examine whether television viewing and music video exposure predict alcohol consumption while going out. METHODS Data were collected in two waves (February 2003 and February 2004). Respondents were a random sample of 1648 first and fourth year secondary school children of Flanders, Belgium. Self-reported general TV viewing and music video exposure at time 1 and the quantity of alcohol consumed while going out at time 2 were measured. Controls were gender, age group, smoking behaviour, and alcohol use (at time 1) and pubertal status (at time 2). RESULTS Overall television viewing per day and music television viewing at time 1 significantly predicted the amount of alcoholic beverages adolescents consumed while going out at time 2. These results remained significant after controlling for alcohol use at time 1, gender, smoking, and pubertal status. CONCLUSIONS TV viewing habits are a significant predictor of alcohol consumption while going out. TV viewing might cause an increase in alcohol consumption or might be an early symptom of developing alcohol habits.
Optimal design of stiffened laminate composite cylinder using a hybrid SFL algorithm

Shuffled frog-leaping algorithm (SFLA), a memetic meta-heuristic, is proved to be a successful combinatorial optimization algorithm and applied to several engineering problems. However, its potential is not explored in the context of laminate stacking sequence optimization of composite structures. In this article, we propose a hybrid version of SFLA for solving the combinatorial optimization problem associated with lay-up sequence optimization of laminate composite structures. In order to improve the computational performance as well as reliability of the optimal solutions, a customized neighborhood search algorithm and an adaptive search factor are incorporated in to the SFL algorithm to accelerate the convergence characteristics. Apart from this, a crossover operator is suitably incorporated in the proposed hybrid SFLA. Numerical experiments have been carried out by first considering the problem of buckling and failure load optimization of composite plate and later, optimal design of stiffened composite cylindrical shells. Superior convergence characteristics and robustness of the proposed hybrid SFLA is demonstrated by comparing with other popular meta-heuristic algorithms including genetic algorithms.
Hypersensitivity to perturbation in the quantum kicked top.

For the quantum kicked top we study numerically the distribution of Hilbert-space vectors evolving in the presence of a small random perturbation. For an initial coherent state centered in a chaotic region of the classical dynamics, the evolved perturbed vectors are distributed essentially like random vectors in Hilbert space. In contrast, for an initial coherent state centered near an elliptic (regular) fixed point of the classical dynamics, the evolved perturbed vectors remain close together, explore only a few dimensions of Hilbert space, and do not explore them randomly. These results support and extend the results of earlier studies, thereby providing additional support for a characterization of quantum chaos that uses concepts from information theory.
The effects of magnesium sulphate on sevoflurane minimum alveolar concentrations and haemodynamic responses

Background and objective: Magnesium administered before anaesthesia induction results in a significant reduction in intravenous anaesthetic consumption. The purpose of this study was to evaluate whether the dose of intravenous magnesium sulphate reduces the minimum alveolar anaesthetic concentration of sevoflurane for endotracheal intubation (MACEI) and skin incision (MAC), and attenuates haemodynamic responses. Methods: We studied 60 patients who were scheduled for elective surgery. Patients were not premedicated before induction of anaesthesia and were randomly assigned to receive intravenous saline 0.9% (Group I, n = 20) or magnesium sulphate 30 mg kg−1 bolus + 10 mg kg−1 h−1 continuous infusion (Group II, n = 20) or 50 mg kg−1 bolus + 10 mg kg−1 h−1 continuous infusion (Group III, n = 20). Results: Median and 95% confidence limits for sevoflurane MACEI were 2.68 (2.48‐2.85), 2.88 (2.70‐3.06) and 2.96 (2.70‐3.16), and for sevoflurane MAC were 2.08 (1.76‐2.40), 2.26 (2.08‐2.47) and 2.40 (2.19‐2.68) in Groups I, II and III, respectively. The differences in MACEI and MAC among groups were not statistically significant, except Group III in MAC study (P < 0.05). Mean arterial pressures and heart rate did not increase in Groups II and III after endotracheal intubation and skin incision. Conclusions: Magnesium sulphate administered before induction of anaesthesia increases MAC of sevoflurane and reduces cardiovascular responses to intubation.