Miracle-dz/UniFAR-FTUs huggingface dataset:
Swift multi-wavelength observations of the bright flaring burst GRB 051117A

We report on the temporal and spectral characteristics of the early X-ray emission from the Gamma Ray Burst 051117A as observed by Swift . The superb quality of the early X-ray light-curve and spectra of this source, one of the brightest seen by the X-ray Telescope at such early times, allows an unprecedented look at the spectral and temporal evolution of the prompt and early afterglow emission for this GRB and allows us to place stringent limits on the detection of lines. GRB 051117A displays a highly complex light-curve, with an apparent initial slow decline of slope $\alpha=0.77\pm0.07$ ($f(t)\propto t^{-\alpha}$) dominated by numerous superposed flares of varying amplitude and duration. Between orbits 2 and 3, the X-ray light-curve drops abruptly, highlighting the dominance of flaring activity at early times, and indicating that the central engine for this burst remains active for several kiloseconds after the initial explosion. The late time slope ($t>10^{4}$ s) also decays relatively slowly with a powerlaw index of $\alpha=0.66$, breaking to a steeper slope of 1.1, 170 ks after the BAT trigger. The X-ray light-curve at early times is characteristic of a noise process, consisting of random shots superposed on an underlying powerlaw decay, with individual shots well-modelled by a fast-rise and exponential decay spanning a broad range in rise-times and decay rates. A temporal spectral analysis of the early light-curve shows that the photon index and source intensity are highly correlated with the spectrum being significantly harder when brighter, consistent with the movement of the peak of the Band function to lower energies following individual flares. The high quality spectrum obtained from the first orbit of WT mode data, enables us to place a $3\sigma$ upper limit on the strength of any emission line features of ${\it EW}< 15$ eV, assuming a narrow emission-line of 100 eV at the peak of the effective area.
Chronic stress and sexual function in women.

INTRODUCTION Chronic stress is known to have negative effects on reproduction, but little is known about how it affects the sexual response cycle. The present study examined the relationship between chronic stress and sexual arousal and the mechanisms that mediate this relationship. AIM The aim of this study is to test the relationship between chronic stress and sexual arousal and identify mechanisms that may explain this relationship. We predicted that women experiencing high levels of chronic stress would show lower levels of genital arousal and dehydroepiandrosterone (DHEAS) and higher levels of cortisol and cognitive distraction compared with women with average levels of stress. METHODS Women who were categorized as high in chronic stress (high stress group; n=15) or average in chronic stress (average stress group; n=15) provided saliva samples and watched an erotic film while having their genital and psychological arousal measured. MAIN OUTCOME MEASURES Main outcome measures were vaginal pulse amplitude, psychological arousal, salivary cortisol, salivary DHEAS, and heart rate and compared them between women with high and average levels of chronic stress. RESULTS Women in the high stress group had lower levels of genital, but not psychological arousal, had higher levels of cortisol, and reported more distraction during the erotic film than women in the average stress group. The main predictor of decreased genital sexual arousal was participants' distraction scores. CONCLUSIONS High levels of chronic stress were related to lower levels of genital sexual arousal. Both psychological (distraction) and hormonal (increased cortisol) factors were related to the lower levels of sexual arousal seen in women high in chronic stress, but distraction was the only significant predictor when controlling for other variables.
Analysis of a cellular system for QoS providing under differentiated services

We propose a wireless resource allocation scheme considering mobility for providing quality of service (QoS) under IT micro mobility domain with differentiated services (DiffServ). In this scheme, each base station provides infinite waiting queue for both assured forwarding (AF) and best effort (BE) handoff flows and guard channels for expedited forwarding (EF) handoff flows. This scheme also allows BE flows to overflow over the region reserved for EF flows with the risk of being preempted by the newly arriving EF flows. If there is no idle channel bandwidth in a new cell after a handoff in heavily crowded area, the EF handoff request is just dropped. Hence, it is required to give a statistical guarantee on the EF handoff success in this wireless mobile environment. The remaining channel bandwidth except for the regions reserved for EF flows in a cell is dedicated to both AF and BE flows. The BE flows preempted by the newly arriving EF flows in a cell are queued, and AF handoff flows has preemptive priority over BE flows existing in dedicated region. We derive the dropping probabilities of both EF and AF flows, and the average system time of BE flows by using a transition rate matrix approach. We also obtain the forced termination probability of EF flow and bandwidth utilization.
Metabolomics: a new tool for the investigation of metabolic changes induced by cytomegalovirus

Abstract To date, cytomegalovirus (CMV) is one of the most studied and characterized virus, however the current knowledge on the effect of the human CMV (HCMV) infection on global metabolism is still poorly understood. Metabolomics is a new approach based on the systematic study of the complete set of low molecular weight compounds, both endogenous and exogenous, found within a cell, tissue, biofluid or organism. The purpose of this review is to provide insight into the use of the metabolomic approach on the study of the impact of HCMV on the human metabolome. The results described in this work suggest that metabolomics could be a new tool for HCMV investigation.
Takayasu Arteritis: Diagnosis, Treatment and Prognosis

Takayasu arteritis (TA) is a chronic nonspecific granulomatous vasculitis affecting aorta and its main branches, coronary and pulmonary arteries. TA often occurs in young women and has a characteristic heterogeneity depending on ethnicity and geographical location. Although the pathogenesis of TA remains unclear, the interaction of many factors, such as autoimmunity, inflammation, genetic and environmental factors and so on, is involved in the occurrence and development of TA. Angiography, which is recognized as the gold standard in evaluating vascular lesions in TA, combined with computer tomography angiography (CTA), magnetic resonance angiography (MRA), ultrasonography, 18Fluorodeoxyglucose positron emission tomography (18F-FDG-PET) could not only provide important information for early diagnosis but also detect disease activity, and thus further guide the treatment in TA. In addition, beside the commonly used corticosteroids, immunosuppressive agents, percutaneous transluminal angioplasty (PTA) and surgical revascularization, anti-tumor necrosis factor (TNF) agent has been more widely used in refractory cases of TA. The objective of this review is to systemically describe the pathogenesis, clinical characteristics, diagnosis, treatment and prognosis of TA.
Caffeine and risk of Parkinson's disease in a large cohort of men and women

Caffeine consumption has been associated with a reduced risk of Parkinson's disease (PD). The association is strong and consistent in men, but uncertain in women, possibly because of an interaction with hormone replacement therapy (HRT). We sought to confirm these findings using data on PD incidence in the Cancer Prevention Study II Nutrition Cohort (CPS II–Nutrition), a large, prospective study of men and women. We conducted a prospective study of caffeine intake and risk of PD within the CPS II Nutrition Cohort. Intakes of coffee and other sources of caffeine were assessed at baseline. Incident cases of PD (n = 317; 197 men and 120 women) were confirmed by treating physicians and medical record review. Relative risks (RRs) were estimated using proportional hazards models, adjusting for age, smoking, and alcohol consumption. After adjustment for age, smoking, and alcohol intake, high caffeine consumption was associated with a reduced risk of PD. The RR comparing the 5th to the 1st quintile of caffeine intake was 0.43 (95% confidence interval [CI]: 0.26, 0.71; P trend = <0.002) in men, and 0.61 (95% CI: 0.34, 1.09; P trend = 0.05) in women. Among women, this association was stronger among never users of HRT (RR = 0.32) than among ever users (RR = 0.81; P interaction = 0.15). Consumption of decaffeinated coffee was not associated with PD risk. Findings from this large, prospective study of men and women are consistent with a protective effect of caffeine intake on PD incidence, with an attenuating influence of HRT in women. © 2012 Movement Disorder Society
MicroRNAs and drought responses in sugarcane

There is a growing demand for renewable energy, and sugarcane is a promising bioenergy crop. In Brazil, the largest sugarcane producer in the world, sugarcane plantations are expanding into areas where severe droughts are common. Recent evidence has highlighted the role of miRNAs in regulating drought responses in several species, including sugarcane. This review summarizes the data from miRNA expression profiles observed in a wide array of experimental conditions using different sugarcane cultivars that differ in their tolerance to drought. We uncovered a complex regulation of sugarcane miRNAs in response to drought and discussed these data with the miRNA profiles observed in other plant species. The predicted miRNA targets revealed different transcription factors, proteins involved in tolerance to oxidative stress, cell modification, as well as hormone signaling. Some of these proteins might regulate sugarcane responses to drought, such as reduction of internode growth and shoot branching and increased leaf senescence. A better understanding on the regulatory network from miRNAs and their targets under drought stress has a great potential to contribute to sugarcane improvement, either as molecular markers as well as by using biotechnological approaches.
Nested effects models for learning signaling networks from perturbation data

Targeted gene perturbations have become a major tool to gain insight into complex cellular processes. In combination with the measurement of downstream effects via DNA microarrays, this approach can be used to gain insight into signaling pathways. Nested Effects Models were first introduced by Markowetz et al. as a probabilistic method to reverse engineer signaling cascades based on the nested structure of downstream perturbation effects. The basic framework was substantially extended later on by Fröhlich et al., Markowetz et al., and Tresch and Markowetz. In this paper, we present a review of the complete methodology with a detailed comparison of so far proposed algorithms on a qualitative and quantitative level. As an application, we present results on estimating the signaling network between 13 genes in the ER‐α pathway of human MCF‐7 breast cancer cells. Comparison with the literature shows a substantial overlap.
A discrete fractional evolutionary transform

In this paper, we present a discrete fractional evolutionary transform (DFrET) for the time-frequency (TF) representation of non-stationary, wide band signals. The time-varying kernel of this transform is used to calculate the evolutionary spectrum. The DFrET kernel are obtained from the coefficients of a discrete fractional Gabor expansion. The proposed DFrET provides a tool for high-resolution representation of multicomponent signals with linear instantaneous frequencies. Performance of the proposed algorithm is illustrated by means of simulations and compared with existing TF methods.
High-dose daunorubicin in older patients with acute myeloid leukemia.

BACKGROUND A complete remission is essential for prolonging survival in patients with acute myeloid leukemia (AML). Daunorubicin is a cornerstone of the induction regimen, but the optimal dose is unknown. In older patients, it is usual to give daunorubicin at a dose of 45 to 50 mg per square meter of body-surface area. METHODS Patients in whom AML or high-risk refractory anemia had been newly diagnosed and who were 60 to 83 years of age (median, 67) were randomly assigned to receive cytarabine, at a dose of 200 mg per square meter by continuous infusion for 7 days, plus daunorubicin for 3 days, either at the conventional dose of 45 mg per square meter (411 patients) or at an escalated dose of 90 mg per square meter (402 patients); this treatment was followed by a second cycle of cytarabine at a dose of 1000 mg per square meter every 12 hours [DOSAGE ERROR CORRECTED] for 6 days. The primary end point was event-free survival. RESULTS The complete remission rates were 64% in the group that received the escalated dose of daunorubicin and 54% in the group that received the conventional dose (P=0.002); the rates of remission after the first cycle of induction treatment were 52% and 35%, respectively (P<0.001). There was no significant difference between the two groups in the incidence of hematologic toxic effects, 30-day mortality (11% and 12% in the two groups, respectively), or the incidence of moderate, severe, or life-threatening adverse events (P=0.08). Survival end points in the two groups did not differ significantly overall, but patients in the escalated-treatment group who were 60 to 65 years of age, as compared with the patients in the same age group who received the conventional dose, had higher rates of complete remission (73% vs. 51%), event-free survival (29% vs. 14%), and overall survival (38% vs. 23%). CONCLUSIONS In patients with AML who are older than 60 years of age, escalation of the dose of daunorubicin to twice the conventional dose, with the entire dose administered in the first induction cycle, effects a more rapid response and a higher response rate than does the conventional dose, without additional toxic effects. (Current Controlled Trials number, ISRCTN77039377; and Netherlands National Trial Register number, NTR212.)
Giardia lamblia infections in children in Ghana

Introduction Though giardiasis is an important public health problem in Ghana, several aspects of its epidemiology, particularly the molecular epidemiology has not been investigated adequately. This could be a major hindrance to effective surveillance and control of giardiasis in the country. The study was carried out to determine the prevalence, risk factors and genotypes of Giardia lamblia infecting children at a paediatric hospital in Ghana. Methods A total of 485 patients including 365 diarrhoea and 120 non-diarrhoea children were enrolled into the study. Stool samples were collected and analysed for parasite presence using microscopy, ELISA and PCR. Positive samples were subsequently characterized into assemblages by PCR-RFLP, and further confirmed with sequencing of the glutamate dehydrogenase (gdh) gene. Epidemiological data on demographic, clinical and behavioral features of the study subjects were also collected. Results Prevalence of G. lamblia infections in diarrhoea and non-diarrhoea children were 5.8% and 5% respectively (P>0.5). Sequence data confirmed Giardia lamblia assemblage B as the predominant genotype in both diarrhoea and non-diarrhoea cases. There was no significant association of G. lamblia infection with any of the epidemiological variables investigated. Conclusion Our findings suggest that assemblage B could be the predominant genotype causing giardiasis in children. Increased public health education focusing on good sanitary practices, particularly among mothers and children, could decrease the risk of G. lamblia infection.
Endoscopic clipping versus injection and thermo-coagulation in the treatment of non-variceal upper gastrointestinal bleeding: a meta-analysis

Background: Hemoclips, injection therapy and thermocoagulation (heater probe or electrocoagulation) are the most commonly used types of endoscopic hemostasis for the control of non-variceal gastrointestinal bleeding. Aim: To compare the efficacy of hemoclips versus injection or thermocoagulation in endoscopic hemostasis by pooling data from the literature. Method: Publications in the English literature (MEDLINE, EMBASE and Cochrane Library) as well as abstracts in major international conferences were searched using the keywords “hemoclips” and “bleeding”, and 15 trials fulfilling the search criteria were found. Outcome measures included: initial hemostasis (after endoscopic intervention); recurrent bleeding; definitive hemostasis (no recurrent bleeding until the end of follow-up); the requirement for surgical intervention; and all-cause mortality. The heterogeneity of trials was examined and the effects were pooled by meta-analysis. Results: Of 1156 patients recruited in the 15 studies, 390 were randomly assigned to receive clips alone, 242 received clips combined with injection, 359 received injection alone, and 165 received thermocoagulation with or without injection. Definitive hemostasis was higher with hemoclips (86.5%) than injection (75.4%; RR 1.14, 95% CI 1.00–1.30), or endoscopic clips with injection (88.5%) compared with injections alone (78.1%; RR 1.13, 95% CI 1.03–1.23), leading to a reduced requirement for surgery but no difference in mortality. Compared with thermocoagulation, there was no improvement in definitive hemostasis with clips (81.5% versus 81.2%; RR 1.00, 95% CI 0.77–1.31). These estimates were robust in sensitivity analyses. There was also no difference between clips and thermocoagulation in rebleeding, the need for surgery and mortality. The reported locations of failed hemoclip applications included posterior wall of duodenal bulb, posterior wall of gastric body and lesser curve of the stomach. Conclusion: Successful application of hemoclips is superior to injection alone but comparable to thermocoagulation in producing definitive hemostasis. There was no difference in all-cause mortality irrespective of the modalities of endoscopic treatment.
Simulation of RDX Decomposition Interacting with Shock Wave via Molecular Dynamics

Cylotrimethylenetrinitramine (RDX), with the chemical formula C3H6N6O6, is an energetic organic molecule used widely in military and industrial commodities of explosives. By stimulating RDX through exerting temperature or mechanical conditions such as impact or friction, decomposition reaction occurs at a very high rate. Molecular dynamics techniques and LAMMPS code with Reactive Force Field (ReaxFF) potential were employed to simulate initiation of RDX. Potential energy variations of the system were calculated over time for five different temperatures up to 100 ps. The products of decomposed system with respect to time were calculated at each stage of stimulation for different values of temperature and thermal initiation stimulation energy in NVT and NVE ensembles. The activation energy of decomposition was calculated 20.230 kcal.mol through Arrhenius equation. The minimum required temperature to produce H2 with temperature decomposition was about 2500 K and production times for several conditions were calculated. The amount of nitrogen and hydrogen production were increased with raising temperature and reached the maximum value at 3000 K. The minimum impetus energy required to form the light species H2 is 66 kcal.mol. `
Recruitment of latent pools of high-avidity CD8+ T cells to the antitumor immune response

A major barrier to successful antitumor vaccination is tolerance of high-avidity T cells specific to tumor antigens. In keeping with this notion, HER-2/neu (neu)-targeted vaccines, which raise strong CD8+ T cell responses to a dominant peptide (RNEU420-429) in WT FVB/N mice and protect them from a neu-expressing tumor challenge, fail to do so in MMTV-neu (neu-N) transgenic mice. However, treatment of neu-N mice with vaccine and cyclophosphamide-containing chemotherapy resulted in tumor protection in a proportion of mice. This effect was specifically abrogated by the transfer of neu-N–derived CD4+CD25+ T cells. RNEU420-429-specific CD8+ T cells were identified only in neu-N mice given vaccine and cyclophosphamide chemotherapy which rejected tumor challenge. Tetramer-binding studies demonstrated that cyclophosphamide pretreatment allowed the activation of high-avidity RNEU420-429-specific CD8+ T cells comparable to those generated from vaccinated FVB/N mice. Cyclophosphamide seemed to inhibit regulatory T (T reg) cells by selectively depleting the cycling population of CD4+CD25+ T cells in neu-N mice. These findings demonstrate that neu-N mice possess latent pools of high-avidity neu-specific CD8+ T cells that can be recruited to produce an effective antitumor response if T reg cells are blocked or removed by using approaches such as administration of cyclophosphamide before vaccination.
PNN for EEG-based Emotion Recognition

The effort to integrate emotions into human-computer interaction (HCI) system has attracted broad attentions. Automatic emotion recognition enables the HCI to become more intelligent and user friendly. Although numerous studies have been performed in this field, emotion recognition is still an extremely challenging task, especially in real-world practice usage. In this work, probabilistic neural network (PNN), with advantage of simple, efficient, and easy to train, was employed to recognize emotions elicited by watching music videos from scalp EEG. The publicly available DEAP emotion database was used to validate our algorithms. The powers of 4 frequency bands of EEG were extracted as features. The results show that the mean classification accuracy of PNN is 81.21% for valence(≥5 and <5) and 81.26% for arousal(≥5 and <5) across 32 subjects, similar with the results of SVM. In addition, they demonstrate that higher frequency bands (beta and gamma) play more important role in emotion classification than lower ones (theta and alpha). For the purpose of practical emotion recognition system, we proposed a ReliefF-based channel selection algorithm to reduce the number of used channels for convenience in practical usage. The results show that while using PNN, the 98% of the maximum classification accuracy can be obtained with only 9 (for valence) and 8 (for arousal) best channels, however, 19 (for valence) and 14 (for arousal) channels are needed while using SVM.
A hierarchical load sharing policy for distributed systems

In dynamic load sharing policies, system state information can be collected in a distributed manner or by a single coordinator node. Two principal policies that belong to the distributed scheme are the sender-initiated and receiver-initiated policies. In the centralized scheme, a central coordinator node is responsible for collecting system state information. Distributed policies do not perform as well as the centralized policy. The performance of distributed policies is sensitive to the variance in job service times and inter-arrival times. Distributed policies, however, are scalable, whereas the centralized policy can cause bottlenecks and fault-tolerance problems for large systems. We propose a hierarchical load sharing policy that minimizes the drawbacks associated with the distributed and centralized policies while retaining their advantages.