Miracle-dz/UniFAR-FTUs huggingface dataset:
Building Agency Capacity for Trauma-Informed Evidence-Based Practice and Field Instruction

Through this article the authors describe how schools of social work offering a child and adolescent trauma specialization actively partnered with their community-based field placement agencies to achieve a dual purpose: help agencies sustain the capacity for evidence-based trauma treatment (EBTT) and provide sufficient EBTT MSW student field placement sites that support preparation of trauma-informed practitioners by schools of social work. Development and description of the specific conceptual framework used to inform the trauma-informed organizational change initiative is described. Results of an Organizational Readiness assessment undertaken at six agencies reflect a strong alignment between implementation drivers identified in the literature (Fixsen, Blase, Naoom, & Wallace, 2009) and the conceptual framework. The manner in which these results are being used by schools of social work and their agency partners in sustaining the implementation of evidence-based trauma treatment is reviewed, and implications for future research, education, and practice is discussed.
On interdomain routing security and pretty secure BGP (psBGP)

It is well known that the Border Gateway Protocol (BGP), the IETF standard interdomain routing protocol, is vulnerable to a variety of attacks, and that a single misconfigured or malicious BGP speaker could result in large-scale service disruption. In this paper, we present Pretty Secure BGP (psBGP)---a proposal for securing BGP, including an architectural overview, design details for significant aspects, and preliminary security and operational analysis. psBGP differs from other security proposals (e.g., S-BGP and soBGP) in that it makes use of a single-level PKI for AS number authentication, a decentralized trust model for verifying the propriety of IP prefix origin, and a rating-based stepwise approach for AS_PATH (integrity) verification. psBGP trades off the strong security guarantees of S-BGP for presumed-simpler operation, e.g., using a PKI with a simple structure, with a small number of certificate types, and of manageable size. psBGP is designed to successfully defend against various (nonmalicious and malicious) threats from uncoordinated BGP speakers, and to be incrementally deployed with incremental benefits.
Nonquadratic Spectral Phase Aberration With Quadratic Temporal Phase Modulation in an Actively Modulated Ultrafast Laser System

Ultrashort pulses can be generated through active modulation techniques, such as the time-lens technique. To achieve better pulse compression, in the time-lens source, quadratic temporal phase modulation was naturally considered as the ideal modulation. However, it is unknown that whether a quadratic temporal phase modulation (equivalently, a linear chirp) translates into a quadratic spectral phase modulation, which can be easily eliminated using compressors. Here, we study this phase transfer both analytically and numerically. Our results indicate that depending on the pulse shape, nonquadratic spectral phase aberration arises even if the temporal phase modulation is quadratic. Consequently, there is observable difference between the compressed pulses with a flat spectral phase and with quadratic spectral phase compensation only. However, both analytical and numerical analyzes show that as quadratic temporal phase modulation increases, nonquadratic spectral phase modulation decreases, and pulse compression with quadratic spectral phase tends to that with a flat spectral phase.
Formation of Plexiform Lesions in Experimental Severe Pulmonary Arterial Hypertension

Background— The plexiform lesion is the hallmark of severe pulmonary arterial hypertension. However, its genesis and hemodynamic effects are largely unknown because of the limited availability of lung tissue samples from patients with pulmonary arterial hypertension and the lack of appropriate animal models. This study investigated whether rats with severe progressive pulmonary hypertension developed plexiform lesions. Methods and Results— After a single subcutaneous injection of the vascular endothelial growth factor receptor blocker Sugen 5416, rats were exposed to hypoxia for 3 weeks. They were then returned to normoxia for an additional 10 to 11 weeks. Hemodynamic and histological examinations were performed at 13 to 14 weeks after the Sugen 5416 injection. All rats developed pulmonary hypertension (right ventricular systolic pressure ≈100 mm Hg) and severe pulmonary arteriopathy, including concentric neointimal and complex plexiform-like lesions. There were 2 patterns of complex lesion formation: a lesion forming within the vessel lumen (stalk-like) and another that projected outside the vessel (aneurysm-like). Immunohistochemical analyses showed that these structures had cellular and molecular features closely resembling human plexiform lesions. Conclusions— Severe, sustained pulmonary hypertension in a very late stage of the Sugen 5416/hypoxia/normoxia-exposed rat is accompanied by the formation of lesions that are indistinguishable from the pulmonary arteriopathy of human pulmonary arterial hypertension. This unique model provides a new and rigorous approach for investigating the genesis, hemodynamic effects, and reversibility of plexiform and other occlusive lesions in pulmonary arterial hypertension.
3-Point RANSAC for fast vision based rotation estimation using GPU technology

In many sensor fusion algorithms, the vision based RANdom Sample Consensus (RANSAC) method is used for estimating motion parameters for autonomous robots. Usually such algorithms estimate both translation and rotation parameters together which makes them inefficient solutions for merely rotation estimation purposes. This paper presents a novel 3-point RANSAC algorithm for estimating only the rotation parameters between two camera frames which can be utilized as a high rate source of information for a camera-IMU sensor fusion system. The main advantage of our proposed approach is that it performs less computations and requires fewer iterations for achieving the best result. Despite many previous works that validate each hypothesis for all of data points and count the number of inliers for it, we use a voting based scheme for selecting the best rotation among all primary answers. This methodology is much more faster than the traditional inlier based approach and is more efficient for parallel implementation of RANSAC iterations. We also investigate parallel implementation of the proposed 3-point RANSAC using CUDA technology which leads to a great improvement in the processing time of estimation algorithm. We have utilized real datasets for evaluation of our algorithm and also compared it with the well-known 8-point algorithm in terms of accuracy and speed. The results show that the proposed approach improves the speed of estimation algorithm up to 150 times faster than the 8-point algorithm with similar accuracy.
catena-Poly[[triaquacopper(II)]-μ2-furan-2,5-dicarboxylato-κ4 O 1,O 2:O 2,O 2′]

In the title compound, [Cu(C6H2O5)(H2O)3]n, an infinite chain is formed along [001] by linking of the Cu(OH2)3O4 cluster with one carboxylate group of the furan-2,5-dicarboxylate ligand. Adjacent chains are linked by Owater—H⋯O hydrogen-bonding interactions. The Cu(OH2)3O4 cluster displays a pentagonal bipyrimadal geometry with two weak coordinations [Cu—Ofuran = 2.790 (2) Å) and Cu—Ocarboxylate = 2.684 (2) Å] and two water molecules located in axial positions.
Adaptive disk scheduling in a multimedia DBMS

In this paper, we present APEX, a disk scheduling framework with QoS support, designed for environments with highly varying disk bandwidth usage. In particular, we focus on a Learning-on-Demand scenario supported by a multimedia database management system, where students can search for, and play back multimedia-based learning material. APEX is based on a two-level scheduling architecture, where the upper level realizes different service classes using a set of queues, while the lower level distributes available disk bandwidth among these queues.In this paper, we focus on the low-level scheduling in APEX, which is based on an extended token bucket algorithm. The disk requests scheduled for service are assembled into batches, which render possible good efficiency for the disk. Combined with a very efficient work-conservation scheme, this enables APEX to apply bandwidth where it is needed, without efficiency loss. We demonstrate, through simulations, that APEX provides both higher throughput and lower response times than other mixed-media disk schedulers, while still avoiding deadline violations for real-time requests. We also show its robustness with respect to misaligned bandwidth allocation.
An Analytical Solidification Model for Solute Redistribution during of Planar, Columnar, or Equiaxed Morphology

Existing models for solute redistribution (microsegregation) during solidification were reviewed. There are no analytical models that take into account limited diffusion in both the liquid and the solid phases. A new analytical mathematical model for solute redistribution was developed. Diffusion in liquid and in solid was considered. This model does not require a prescribed movement of the interface. It can be used for one-dimensional (l-D) (plate), two-dimensional (cylinder), or three-dimensional (3-D) (sphere) calculations. Thus, it is possible to calculate microsegregation at the level of primary or secondary arm spacing for columnar dendrites or for equiaxed dendrites. The solution was compared with calculations based on existing models, as well as with some available experimental data for the segregation of base elements in as cast A1-4.9 wt pct Cu, INCONEL 718, 625, and plain carbon (0.13 wt pct C) steel.
Cardiac autonomic regulation after lung exposure to carbon nanotubes

The ultrafine (UF) component of airborne pollution may impair cardiovascular autonomic control, a high-risk condition for cardiovascular adverse events. Since engineered nanoparticles, such as single-walled carbon nanotubes (SWCNTs) share physicochemical properties with UF, they might have similar adverse effects. Aim of the study was to evaluate arterial baroreflex function (BRF) at baseline, 24 h after the first instillation, immediately before the second one, and 2 weeks later, in adult Wystar-Kyoto conscious rats undergoing two intratracheal instillations of SWCNT (eight rats) or phosphate buffer saline (PBS) (five rats) at 2-week interval. During each session, 30-min continuous recording of arterial pressure and pulse interval was performed by a telemetered catheter implanted in the abdominal aorta of the rats. BRF was studied by the sequence technique. SWCNTs dispersed in PBS (1 mg/ml) were administered immediately after sonication (1 μg/g body weight). A significant decrease in the number of baroreflex sequences (from 498 ± 27.1 at baseline to 287 ± 40.2 at the recording performed after 4 weeks; P < 0.05) was observed in SWCNT-instilled rats, whereas no significant change was detected in controls. These data suggest that SWCNTs may alter the BRF, thus affecting the autonomic cardiovascular control regulation.
Update of the drug resistance mutations in HIV-1: March 2013.

In this update, 2 integrase strand transfer inhibitors (InSTIs), elvitegra-vir and dolutegravir, have become available and were added to the fig-ure. Elvitegravir was approved by the US Food and Drug Administration (FDA) in August 2012 for HIV-1 treat-ment-naive patients as part of a fixed-dose combination of elvitegravir/ cobicistat/tenofovir/emtricitabine.
Virtual Story Generation : from TALESPIN to the Virtual Storyteller

In this seminar report we describe two story generation systems: TALESPIN, one of the earliest approaches, and the Virtual Storyteller, one of the latest approaches. Though the former produces compelling stories, we show why the latter produces stories which are more close to human produced stories. We will discuss similarities and differences of the two systems. In particular, we will show that the main idea (characterand goal-orientation) is the same in both, and the main difference is that the Virtual Storyteller distinguishes between the fabula and story text generation, while TALE-SPIN does not. Finally, we present some open questions and ideas on how to improve virtual story generation.
Polo‐like kinase‐1 triggers histone phosphorylation by Haspin in mitosis

Histone modifications coordinate the chromatin localization of key regulatory factors in mitosis. For example, mitotic phosphorylation of Histone H3 threonine‐3 (H3T3ph) by Haspin creates a binding site for the chromosomal passenger complex (CPC). However, how these histone modifications are spatiotemporally controlled during the cell cycle is unclear. Here we show that Plk1 binds to Haspin in a Cdk1‐phosphorylation‐dependent manner. Reducing Plk1 activity decreases the phosphorylation of Haspin and inhibits H3T3ph, particularly in prophase, suggesting that Plk1 is required for initial activation of Haspin in early mitosis. These studies demonstrate that Plk1 can positively regulate CPC recruitment in mitosis.
Automated Tracking of Stem Cell Lineages of Arabidopsis Shoot Apex Using Local Graph Matching

SUMMARY Shoot apical meristems (SAMs) of higher plants harbor stem-cell niches. The cells of the stem-cell niche are organized into spatial domains of distinct function and cell behaviors. A coordinated interplay between cell growth dynamics and changes in gene expression is critical to ensure stem-cell homeostasis and organ differentiation. Exploring the causal relationships between cell growth patterns and gene expression dynamics requires quantitative methods to analyze cell behaviors from time-lapse imagery. Although technical breakthroughs in live-imaging methods have revealed spatio-temporal dynamics of SAM-cell growth patterns, robust computational methods for cell segmentation and automated tracking of cells have not been developed. Here we present a local graph matching-based method for automated-tracking of cells and cell divisions of SAMs of Arabidopsis thaliana. The cells of the SAM are tightly clustered in space which poses a unique challenge in computing spatio-temporal correspondences of cells. The local graph-matching principle efficiently exploits the geometric structure and topology of the relative positions of cells in obtaining spatio-temporal correspondences. The tracker integrates information across multiple slices in which a cell may be properly imaged, thus providing robustness to cell tracking in noisy live-imaging datasets. By relying on the local geometry and topology, the method is able to track cells in areas of high curvature such as regions of primordial outgrowth. The cell tracker not only computes the correspondences of cells across spatio-temporal scale, but it also detects cell division events, and identifies daughter cells upon divisions, thus allowing automated estimation of cell lineages from images captured over a period of 72 h. The method presented here should enable quantitative analysis of cell growth patterns and thus facilitating the development of in silico models for SAM growth.
FMRFamide-Like Peptides (FLPs) Enhance Voltage-Gated Calcium Currents to Elicit Muscle Contraction in the Human Parasite Schistosoma mansoni

Schistosomes are amongst the most important and neglected pathogens in the world, and schistosomiasis control relies almost exclusively on a single drug. The neuromuscular system of schistosomes is fertile ground for therapeutic intervention, yet the details of physiological events involved in neuromuscular function remain largely unknown. Short amidated neuropeptides, FMRFamide-like peptides (FLPs), are distributed abundantly throughout the nervous system of every flatworm examined and they produce potent myoexcitation. Our goal here was to determine the mechanism by which FLPs elicit contractions of schistosome muscle fibers. Contraction studies showed that the FLP Tyr-Ile-Arg-Phe-amide (YIRFamide) contracts the muscle fibers through a mechanism that requires Ca2+ influx through sarcolemmal voltage operated Ca2+ channels (VOCCs), as the contractions are inhibited by classical VOCC blockers nicardipine, verapamil and methoxyverapamil. Whole-cell patch-clamp experiments revealed that inward currents through VOCCs are significantly and reversibly enhanced by the application of 1 µM YIRFamide; the sustained inward currents were increased to 190% of controls and the peak currents were increased to 180%. In order to examine the biochemical link between the FLP receptor and the VOCCs, PKC inhibitors calphostin C, RO 31–8220 and chelerythrine were tested and all produced concentration dependent block of the contractions elicited by 1 µM YIRFamide. Taken together, the data show that FLPs elicit contractions by enhancing Ca2+ influx through VOCC currents using a PKC-dependent pathway.
How to track bacteria.

A microscope is described which automatically remains focused on individual motile bacteria. The container in which the bacteria are suspended is moved in such a way that the position of a given organism remains fixed; x, y, and z drive signals provide a measure of its displacement relative to the suspension medium. Records are shown of the motion of Escherischia coli.
Synthesis and Functionalization of Carbon and Boron Nitride Nanomaterials and Their Applications

Carbon and boron-nitride based nanomaterials possess many exciting properties making them suitable for numerous applications spanning from electronics to advanced composites. However, these materials when synthesized often differ significantly from the idealized crystals usually considered theoretically. A thorough understanding of the structure of the materials as synthesized and how the resultant materials can be utilized for specific application purposes is required such that these applications can be effectively realized. To this end, the synthesis and characterization of carbon and boron-nitride based nanomaterials is undertaken with specific application purposes in mind. As a potential scalable synthetic route for graphene, graphene oxide (GO) and reduced graphene oxide are synthesized and characterized using atomic resolution electron microscopy. This elucidates their underlying structures revealing that the reduced form of GO does not resemble pristine graphene. The long-standing debate over the structure of GO is successfully ended with this study given the direct observation of the atomic structure of this material. To develop advanced composite materials, the functionalization of carbon and boron nitride nanotubes is undertaken. The characterization of their functionalization and incorporation within composite materials, specifically within a Kevlar polymer matrix, is presented to allow for the development of composites with significantly enhanced mechanical properties. Given a significant body of theoretical work paired with a single previous synthetic success, the synthesis of boron nitride nanoribbons is outlined. The first scalable synthesis of boron nitride nanoribbons is demonstrated resulting in long, consistent width, narrow, few-layer boron nitride nanoribbons which could be ideal for addressing these theoretical considerations. To establish a method for the synthesis of thin hexagonal-boron nitride (h-BN), the design of a specialized CVD system is described. The material resulting from this system is analyzed with methods including atomic resolution electron microscopy with the results informing future approaches for the synthesis of h-BN. Finally, high surface area boron nitride materials should be promising for hydrogen storage applications, especially if templated with a microporous scaffold. To this end, the first synthesis of a high surface area, microporous boron-nitride material is accomplished and the resultant surface areas of these materials are reported.
Spontaneous Termination of an Induced Pseudopregnancy in the Djungarian Hamster, Phodopus campbelli


The mechanisms which underlie the termination of a functional pseudopregnancy and the return to a behavioral estrus in the Djungarian hamster, Phodopus campbelli, were investigated through changes in (1) serum prolactin concentrations; (2) progesterone and estradiol concentrations in the serum and extracted corpus luteum, ovulatory follicle, and non-luteal portion of the ovary; and (3) corpus luteum and non-luteal ovary weight. Females were asynchronous in the timing of resumption of behavioral estrus, ranging between Days 9 and 11 postcoitus with the mode on Day 10. Unlike proestrus of a cycle, mating following a pseudopregnancy was associated with a large surge of progesterone in serum. Early pseudopregnancy was characterized by high pulsatile changes in serum prolactin, stable serum and corpus luteum progesterone, low concentrations of serum and ovarian estradiol, and high, stable corpus luteum weight. Although the day of return to behavioral estrus varied across females, there was synchrony between females in the timing of regression of corpus luteum function and structure. Serum prolactin and progesterone levels significantly decreased by Day 7 but were not followed by a decrease in corpus luteum progesterone content until Day 8. Changes in luteal function were also uncoupled from changes in weight since luteal weight remained high through Day 8 before disappearing from the ovary by Day 9. The pattern and level of prolactin surges during pseudopregnancy is the same as that seen during pregnancy, suggesting that the termination of coitally induced pituitary prolactin surges is spontaneous.
STUDIES ON DEVELOPMENT OF HIGH PROTEIN-LOW CALORIE COOKIES

Cookies rich in protein and low in calories were developed by substituting wheat flour (Maida) with defatted soy flour (DSF) and cane sugar with Stevia leaves powder (SLP). Standardisation of Maida: DSF ratio was done by evaluating the physicochemical parameters and sensory quality of the cookies prepared from the various blends. Once standardisation of blends was completed, the standardised flour mix was used to manufacture cookies by replacing cane sugar with SLP at levels of 0,10,15,20 and 25%. These cookies were then packed in LDPE, HDPE and PP films and stored for a period of 90 days under ambient conditions to assess the quality of the cookies based on sensory and storage parameters. Cookies containing 20% DSF and 20% SLP resulted in 109.36 % increase in proteins and 10.18 % decrease in calories. Storage studies revealed that cookies stored in HDPE package to have good sensory acceptability. In conclusion, DSF and SLP can be incorporated at 20% level in formulation of high protein and low calorie cookies without affecting the overall acceptability of cookie.
Optimisation of silane grafting in single screw extruder

Abstract Reactive extrusion is an attractive means of polymer processing since the shaping and reaction takes place in a single operation. Silane grafting of low density polyethylene has been achieved in a single screw extruder. The optimum conditions for silane grafting, i.e. temperature, shear rate, and silane and dicumyl peroxide concentrations, were determined on a torque rheometer and extrusion was then performed under optimum conditions. The study shows that an optimum low level of grafting/crosslinking can be introduced into polyethylene during extrusion for better mechanical behaviour and/or thermal stability without aecting the processability.