Miracle-dz/UniFAR-FTUs huggingface dataset:
Fatty Acid Synthase Inhibitors from Geum japonicum Thunb. var. chinense

Bioassay-guided fractionation of the MeOH extract of Geum japonicum Thunb. var. chinense using the fatty acid synthase inhibition assay led to the isolation of a new dimeric ellagitannin, gemin G (1), together with six known compounds, gemin A (2), casuarinin (3), pedunculagin (4), potentillin (5) , tellimagrandin II (6), and ellagic acid (7). Their structures were determined on the basis of spectroscopic analyses. Compounds 1-7 displayed strong inhibitory activities on fatty acid synthase with IC(50) values in the range of 0.21-41.4 microM. Compounds 1-4 exhibited significant antioxidant activities higher than vitamin C in the ORAC assay. Compounds 1 and 2 also showed weak cytotoxic effects on BGC-823 cell.
Semi-Automatic Query Expansion using Most Discriminant Words

Most casual users of IR systems type short queries. With current indexing technologies, short queries return enormous amount of results that may be impossible to examinate carefully. If users not find what they are looking for between the first 10/100 results, they may stop searching, losing the important results wrongly ranked by the search engine. While users generally know what they are looking for, the task of express their desires in a compact, precise, written form, i.e. the query, represent a real problem. Word usage is in fact both domain and user dependent, and may easily mislead the search engine. In this report I investigate a new method for query expansion, that exploiting the user’s feedback on some discriminant words, try to increase the focus on the user’s
Factors Controlling the Uptake of Yeast Copper/Zinc Superoxide Dismutase into Mitochondria*

We have previously shown that a fraction of yeast copper/zinc-superoxide dismutase (SOD1) and its copper chaperone CCS localize to the intermembrane space of mitochondria. In the present study, we have focused on the mechanism by which SOD1 is partitioned between cytosolic and mitochondrial pools. Using in vitro mitochondrial import assays, we show that only a very immature form of the SOD1 polypeptide that is apo for both copper and zinc can efficiently enter the mitochondria. Moreover, a conserved disulfide in SOD1 that is essential for activity must be reduced to facilitate mitochondrial uptake of SOD1. Once inside the mitochondria, SOD1 is converted to an active holo enzyme through the same post-translational modifications seen with cytosolic SOD1. The presence of high levels of CCS in the mitochondrial intermembrane space results in enhanced mitochondrial accumulation of SOD1, and this apparently involves CCS-mediated retention of SOD1 within mitochondria. This retention of SOD1 is not dependent on copper loading of the enzyme but does require protein-protein interactions at the heterodimerization interface of SOD1 and CCS as well as conserved cysteine residues in both molecules. A model for how CCS-mediated post-translational modification of SOD1 controls its partitioning between the mitochondria and cytosol will be presented.
Agile adoption experience: A case study in the U.A.E

Agile software development methods and techniques have gained attention in the recent few years. The main motive behind adopting agile software development approach is to improve end-product quality, enhance developer's moral and achieve stakeholder satisfaction. However, Agile adoption always comes with special challenges and thus fundamental organizational changes are necessary for successful outcomes. In this paper we present an in-depth case study for adopting agile methods to a government entity in the United Arab Emirates (U.A.E). The government entity software development teams have used the traditional waterfall approach for many years and decided to move to agile software development approach. This study highlights the challenges faced during the adoption of the Scrum method. Without proper preparation, the challenges will be significant enough to put the agile adoption on hold and make the software development teams go back to the traditional waterfall method.
Journal of Graph Algorithms and Applications a User Study in Similarity Measures for Graph Drawing

The need for a similarity measure for comparing two drawings of graphs arises in problems such as interactive graph drawing and the indexing or browsing of large sets of graphs. Many applications have been based on intuitive ideas of what makes two drawings look similar — for example, the idea that vertex positions should not change much. In this paper, we formally define several of these intuitive ideas of similarity and present the results of a user study designed to evaluate how well these measures reflect human perception of similarity.
Discrete range clustering using Monte Carlo methods

Passive sensing algorithms using electrooptic sensors produce reliable range at sparse locations. Both for automatic guidance and as a display for aiding the pilot, these discrete ranges need to group into sets which correspond to objects in the nearby environment. The focus is on using Monte Carlo methods for clustering range points into meaningful groups. One of the aims is to explore whether simulated annealing methods offer significant advantage over the basic Monte Carlo method for this class of problems. The authors compare three different approaches and present results of application of these algorithms to a helicopter flight sequence. <<ETX>>
Equilibrium-like behavior in far-from-equilibrium chemical reaction networks

In an equilibrium chemical reaction mixture, the number of molecules present obeys a Poisson distribution. We ask when the same is true of the steady state of a nonequilibrium reaction network and obtain an essentially complete answer. In particular, we show that networks with certain topological features must have a Poisson distribution, whatever the reaction rates. Such driven systems also obey an analog of the fluctuation-dissipation theorem. Our results may be relevant to biological systems and to the larger question of how equilibrium concepts might apply to nonequilibrium systems.
A Re-examination of the Selection of the Sensory Organ Precursor of the Bristle Sensilla of Drosophila melanogaster

The bristle sensillum of the imago of Drosophila is made of four cells that arise from a sensory organ precursor cell (SOP). This SOP is selected within proneural clusters (PNC) through a mechanism that involves Notch signalling. PNCs are defined through the expression domains of the proneural genes, whose activities enables cells to become SOPs. They encode tissue specific bHLH proteins that form functional heterodimers with the bHLH protein Daughterless (Da). In the prevailing lateral inhibition model for SOP selection, a transcriptional feedback loop that involves the Notch pathway amplifies small differences of proneural activity between cells of the PNC. As a result only one or two cells accumulate sufficient proneural activity to adopt the SOP fate. Most of the experiments that sustained the prevailing lateral inhibition model were performed a decade ago. We here re-examined the selection process using recently available reagents. Our data suggest a different picture of SOP selection. They indicate that a band-like region of proneural activity exists. In this proneural band the activity of the Notch pathway is required in combination with Emc to define the PNCs. We found a sub-group in the PNCs from which a pre-selected SOP arises. Our data indicate that most imaginal disc cells are able to adopt a proneural state from which they can progress to become SOPs. They further show that bristle formation can occur in the absence of the proneural genes if the function of emc is abolished. These results suggest that the tissue specific proneural proteins of Drosophila have a similar function as in the vertebrates, which is to determine the time of emergence and position of the SOP and to stabilise the proneural state.
Universality Versus Language-Specificity in Listening to Running Speech

Recognizing spoken language involves automatic activation of multiple candidate words. The process of selection between candidates is made more efficient by inhibition of embedded words (like egg in beg) that leave a portion of the input stranded (here, b). Results from European languages suggest that this inhibition occurs when consonants are stranded but not when syllables are stranded. The reason why leftover syllables do not lead to inhibition could be that in principle they might themselves be words; in European languages, a syllable can be a word. In Sesotho (a Bantu language), however, a single syllable cannot be a word. We report that in Sesotho, word recognition is inhibited by stranded consonants, but stranded monosyllables produce no more difficulty than stranded bisyllables (which could be Sesotho words). This finding suggests that the viability constraint which inhibits spurious embedded word candidates is not sensitive to language-specific word structure, but is universal.
Intermediation in a Sharing Economy: Insurance, Moral Hazard, and Rent Extraction

Abstract A key impediment to sharing is a lender’s concern about damage to a lent item due to unobservable actions by a renter, usually resulting in moral hazard. This paper shows how an intermediary can eliminate the moral hazard problem by providing optimal insurance to the lender and first-best incentives to the renter to exert care, as long as market participants are risk neutral. The solution is illustrated for the collaborative housing market but applies in principle to any sharing market with vertically differentiated goods. A population of renters, heterogeneous both in their preferences for housing quality and with respect to the amount of care they exert in a rental situation, face a choice between collaborative housing and staying at a local hotel. The private hosts choose their prices strategically, and the intermediary sets commission rates on both sides of the market as well as insurance terms for the rental agreement. The latter are set to eliminate moral hazard. The intermediary is able to extract the gains the hosts would earn if transacting directly. Finally, even if hotels set their prices at the outset so as to maximize collusive profits, collaborative housing persists at substantial market shares, regardless of the difference between the efficiencies of hosts and hotels to reduce renters’ cost of effort. The aggregate of hosts, intermediary, and hotels benefits from (a variety in) these effort costs, which indicates that the intermediated sharing of goods is an economically viable, robust phenomenon.
Annotated Probabilistic Temporal Logic: Approximate Fixpoint Implementation

Annotated Probabilistic Temporal (APT) logic programs support building applications where we wish to reason about statements of the form “Formula G becomes true with a probability in the range [L, U] within (or in exactly) Δt time units after formula F became true. ” In this paper, we present a sound, but incomplete fixpoint operator that can be used to check consistency and entailment in APT logic programs. We present the first implementation of APT-logic programs and evaluate both its compute time and convergence on a suite of 23 ground APT-logic programs that were automatically learned from two real-world data sets. In both cases, the APT-logic programs contained up to 1,000 ground rules. In one data set, entailment problems were solved on average in under 0.1 seconds per ground rule, while in the other, it took up to 1.3 seconds per ground rule. Consistency was also checked in a reasonable amount of time. When discussing entailment of APT-logic formulas, convergence of the fixpoint operator refers to (U − L) being below a certain threshold. We show that on virtually all of the 23 automatically generated APT-logic programs, convergence was quick---often in just 2-3 iterations of the fixpoint operator. Thus, our implementation is a practical first step towards checking consistency and entailment in temporal probabilistic logics without independence or Markovian assumptions.
Optimised fuzzy controller for improved comfort level during transitions in Cruise and Adaptive Cruise Control Vehicles

Conventional controllers like Proportional Derivative (PD), Proportional Integral (PI) and Proportional Integral Derivative (PID) controllers were used in implementing Velocity Control Mode (VCM) in Cruise Control (CC) and Adaptive Cruise control (ACC) vehicles. Transition that occur in "resume mode" of CC and transitions that occur during switching from Distance Control Mode (DCM) to VCM for an ACC is considered primarily for the design of a controller. This transition creates the disturbance in the comfort level of the vehicle occupants. Disturbance above a predefined level may lead to rejection of such driver assistance systems by the user. The proposed optimized fuzzy controller using Genetic Algorithm (GA) has shown a better performance over the conventional CC system in terms of minimizing the jerk by controlling the acceleration within the comfortable level.
Alcohol Consumption and Unwanted Sexual Experiences Among College Females: The Mediating Role of Protective Behavioral Strategies

ALCOHOL CONSUMPTION AND UNWANTED SEXUAL EXPERIENCES AMONG COLLEGE FEMALES: THE MEDIATING ROLE OF PROTECTIVE BEHAVIORAL STRATEGIES by Kayla Darlene Moorer December 2013 The narrowing gender gap regarding consumption has resulted in more alcoholrelated consequences specific to females. Compared to males, females report more sexual consequences, such as doing something they later regret, as a result of alcohol consumption. For this reason, there is a vital need for researchers to identify active methods that females can engage in while consuming alcohol in order to reduce the risk of unwanted sexual experiences (UWS). Protective behavioral strategies (PBS) have been shown to decrease overall alcohol-related consequences, but further investigation is needed to determine which strategies are most influential in reducing the occurrence of specific alcohol-related negative consequences (e.g., unwanted sexual experiences). The purpose of this study is to determine whether PBS use mediates the relationship between alcohol consumption and UWS in female college students. Additionally, the present study seeks to determine which type of PBS (limiting stopping drinking, manner of drinking, or serious harm reduction) is most influential in mediating the relationship between alcohol consumption and UWS. Based on the literature, it is hypothesized that PBS use will serve as a mediator and that serious harm reduction strategies will be most influential in mediating the relationship. Various measures of alcohol consumption, UWS, and PBS use will be administered via online surveys to female undergraduates
Data mining source code to facilitate program comprehension: experiments on clustering data retrieved from C++ programs

This paper presents ongoing work on using data mining to discover knowledge about software systems thus facilitating program comprehension. We discuss how this work fits in the context of tool supported maintenance and comprehension and report on applying a new methodology on C++ programs. The overall framework can provide practical insights and guide the maintainer through the specifics of systems, assuming little familiarity with these. The contribution of this work is two-fold: it provides a model and associated method to extract data from C++ source code which is subsequently to be mined, and evaluates a proposed framework for clustering such data to obtain useful knowledge. The methodology is evaluated on three open source applications, results are assessed and conclusions are presented. This paper concludes with directions for future work.
Do MPC voting records matter? Predictability and public anticipation of monetary policy in Poland

This paper provides empirical evidence in favor of more promptly release of Monetary Policy Council voting records, not published by the National Bank of Poland before the next MPC meeting. The study shows that the voting records, if they were available, could enhance the predictability and improve the private sector forecasts of upcoming policy decisions. They reveal strong and robust predictive ability as a supplementary statistics when controlling for other economic and …nancial factors relevant for policy rate anticipation. The dissenting votes contain information not embedded in various Taylor type rules, the market anticipation of future policy as revealed by market interest rates, the MPC statements on ’policy bias’and ’balance of risks’, and even explicit forecasts made by market analysts in Reuters surveys just before each policymaking meeting. Moreover, the direction and dispersion of dissent explain those of private sector forecast errors. These …ndings are based on the voting patterns only, i.e., without knowledge of policymakers’names attached.
Assessment of Waste Stabilization Ponds for the Treatment of Hospital Wastewater: The Case of Hawassa University Referral Hospital

This paper is aimed to examine the suitability of a series of facultative and maturation ponds for the treatment of hospital wastewater. Sampling were done in different time periods from 2009-2010. The hospital produced 470 liters of wastewater per occupied bed per day. The percentage treatment efficiency of the pond was 94.11, 87.72, 87.1, 86.52, 68.58, 54.81, 54.59, 31.95, 18.12 and 10.58 for BOD , Sulfide, TSS, COD, Nitrate, 5 Nitrite, Total Nitrogen, Total Dissolved Solids, Conductivity and Chloride respectively in decreasing order. However, there was a 204.85% increment for total Ammonia in the effluent of the pond. The organic loading rate was 678.7 kg/he/day and the BOD /COD ratio was 0.455. There were 204.2, 13.1, 8.1, 6.2, 4.5, 2.9 fold increments 5 in concentrations of Zn, Cd, Fe, Pb, Co and Cr respectively in the final treated effluent in the recent year. The treatment efficiency for total and fecal coliform bacteria were 99.74% and 99.36% respectively. However, the effluent still contain large numbers of these bacteria, not suitable for irrigation and aquaculture. The treatment plant is not efficient to threat some selected physicochemical substances. Use of constructed wetlands in conjunction with the existing treatment system is recommended.
A Size Threshold Limits Prion Transmission and Establishes Phenotypic Diversity

Processing Prion Phenotype How misfolding of a prion protein translates into transmissible changes in cellular physiology is unclear. Derdowski et al. (p. 680) integrated a computational model of prion aggregate dynamics with an empirical analysis of the physical and functional dynamics of prion protein in yeast cells. Remarkably, they found that prion phenotypes resulted from fluctuations in the accumulation of aggregates and suggested that it is the process rather than the product of protein misfolding that is crucial in establishing the severity or stability of the resulting phenotype. Yeast prion conformations specify phenotypes by affecting the size distribution of aggregates. According to the prion hypothesis, atypical phenotypes arise when a prion protein adopts an alternative conformation and persist when that form assembles into self-replicating aggregates. Amyloid formation in vitro provides a model for this protein-misfolding pathway, but the mechanism by which this process interacts with the cellular environment to produce transmissible phenotypes is poorly understood. Using the yeast prion Sup35/[PSI+], we found that protein conformation determined the size distribution of aggregates through its interactions with a molecular chaperone. Shifts in this range created variations in aggregate abundance among cells because of a size threshold for transmission, and this heterogeneity, along with aggregate growth and fragmentation, induced age-dependent fluctuations in phenotype. Thus, prion conformations may specify phenotypes as population averages in a dynamic system.
On computing parameters to find direction of disturbance propagation using transfer entropy method

The problem of disturbance propagation in industrial process control loops has received considerable attention. Causes of plant-wide disturbances include non-linear limit cycles in control loops, controller interactions and tuning problems. Once oscilattions are detected, knowledge about cause and effect in control loops is fundamental for identifying the root causes. In [1], a method for calculating transfer entropy was proposed using five tuning parameters that were constant in all calculations. In this paper, two of these parameters were computed for each pair of variables, resulting in better conclusions about cause and effect relationships amongst the signals. The usefulness of our proposal is demonstrated through simulations and application to an industrial case.
Identity Authentication Scheme Expansion Based on Speaker Verification

Although in theory, the speaker verification accuracy will not decrease with the number of users increasing, in fact, is not the case. In view of this situation, this paper expands the identity authentication scheme based on speaker recognition which is safe but deficient. After expansion, the identity authentication scheme based on speaker verification is more effective and practical.
GADD45A، یک مارکر مولکولی بالقوه در سرطان اپی تلیال سروزی تخمدان

کچ هدي شيپ هنيمز و فده : نادمخت ناطرس مراهچ ي تلع ن گرم و ريم م نانز رد ناطرس اب طبترم ي دشاب ، هب روظنم شهاک گرم مو ي ر شان ي زا نآ ، اسانش يي زرا و ي با ي ب ي اهرکرامو ي خشت ي ص ي لوا ي هک ه ا صتخم ي دنتسه ناطرس ن رورض ي م ي دشاب ، مها هب هجوت اب ي نژ شقن ت GADD45A لولس گرم و اقب رد ي ، غت يي ب تار ي نآ نا فلتخم عاونا رد تفاب اه ي شوخ خ ي م ، لارودروب ي خدب و ن ي م زورس ناطرس هب قلعتم ي پا ي لت ي ا رد نادمخت لا ي قحت ن ي ق سرربدروم ي . تسا هتفرگ رارق راک شور و داوم : هنومن اه ي هب طوبرم هزات تفاب اه ي زورس فلتخم ي لماش نادمخت ۷۵ روموت هنومن ي و ۲۰ نامز هلصاف رد لامرن تفاب هنومن ي ۹۳ دادرخ ات ۹۶ ب زا ي نارام هعجارم هدننک ب هب ي مورا رثوک ناتسرام ي ب و ه ي ربت ارهزلا ناتسرام ي ز عمج يروآ امد رد و ي -80 رادهگن ي دش ، زا سپ خشت ي ژولوتاپ طسوت ص ي تس ، جارختسا
Discourse Structure and Information Structure: Interfaces and Prosodic Realization

In this paper we review the current state of research on the issue of discourse structure (DS)/information structure (IS) interface. This field has received a lot of attention from discourse semanticists and pragmatists, and has made substantial progress in recent years. In this paper we summarize the relevant studies. In addition, we look at the issue of DS/ISinteraction at a different level—that of phonetics. It is known that both information structure and discourse structure can be realized prosodically, but the issue of phonetic interaction between the prosodic devices they employ has hardly ever been discussed in this context. We think that a proper consideration of this aspect of DS/IS-interaction would enrich our understanding of the phenomenon, and hence we formulate some related research-programmatic positions.