Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimized software synthesis for digital signal processing algorithms: an evolutionary approach

Based on the model of synchronous data flow (SDF), so-called single appearance schedules are known to provide memory-optimal schedules. Among these, the problem of buffer memory optimization is treated: (1) an evolutionary algorithm (EA) is applied to efficiently explore the (in general) exponential search space of actor firing orders; (2) for each order, the buffer costs are evaluated by applying a dynamic programming post-optimization step (GDPPO).
T4 Rectal Cancer: Analysis of Patient Outcome after Surgical Excision

Locally advanced rectal cancer dictates a major surgical undertaking, which includes en bloc resection of the rectum and all involved organs. The aim of this study was to evaluate patient outcome and compare multimodality treatment options after various surgical approaches from one institution for T4 rectal cancer. A retrospective chart review identified 24 patients who were operated on for advanced primary rectal cancer invading adjacent structures (T4) over a 5½-year period. The types of treatment and outcome were analyzed. From these 24 patients, the most frequently involved organ was the bladder (33%). A total of 16 patients underwent chemoradiotherapy. There were 12 complications (50%), the most common being wound infection (33% of complications, 17% overall). Nine patients had nodal disease. Disease-free survival was 54 per cent, and overall survival was 75 per cent. However, disease-free survival in node-negative patients was 67 per cent versus 33 per cent in node-positive individuals. Out of the six patients who died in this review, five (83%) received chemoradiotherapy. Operations for advanced primary rectal cancer with involvement of adjacent organs are major procedures associated with high morbidity. Patients without nodal disease may have long-term survival despite the locally advanced tumor. Interestingly, neoadjuvant therapy, adjuvant, or both, did not increase survival.
Assessment Bioavailability of Carotenoids and Tocopherols from Broccoli : In Vivo and In Vitro

[PDF] [Full Text] [Abstract] , December 1, 2006; 231 (11): 1733-1738. Exp Biol Med F. Granado, B. Olmedilla, C. Herrero, B. Perez-Sacristan, I. Blanco and S. Blazquez Assessment Bioavailability of Carotenoids and Tocopherols from Broccoli: In Vivo and In Vitro [PDF] [Full Text] [Abstract] , October 1, 2007; 137 (10): 2229-2233. J. Nutr. S. K. Thakkar, B. Maziya-Dixon, A. G. O. Dixon and M. L. Failla Directly Proportional to {beta}-Carotene Content in Different Genotypes of Cassava {beta}-Carotene Micellarization during in Vitro Digestion and Uptake by Caco-2 Cells Is [PDF] [Full Text] [Abstract] , March 1, 2008; 138 (3): 482-486. J. Nutr. M. L. Failla, C. Chitchumroonchokchai and B. K. Ishida Those of All-trans Lycopene In Vitro Micellarization and Intestinal Cell Uptake of cis Isomers of Lycopene Exceed [PDF] [Full Text] [Abstract] , August 1, 2008; 138 (8): 1432-1436. J. Nutr. Bohm and P. Borel M. Moussa, J.-F. Landrier, E. Reboul, O. Ghiringhelli, C. Comera, X. Collet, K. Frohlich, V. Class B Type I but Not Niemann-Pick C1-Like 1 Lycopene Absorption in Human Intestinal Cells and in Mice Involves Scavenger Receptor [PDF] [Full Text] [Abstract] , May 1, 2009; 139 (5): 876-883. J. Nutr. S. Blanquet-Diot, M. Soufi, M. Rambeau, E. Rock and M. Alric Vitro Gastrointestinal System Digestive Stability of Xanthophylls Exceeds That of Carotenes As Studied in a Dynamic in
Fetal Cerebral Hemorrhage Caused by Vitamin K Deficiency After Complicated Bariatric Surgery

BACKGROUND: Restrictive bariatric surgery decreases obesity-related morbidity and mortality. With the widespread use of these interventions, an increasing number of women who have undergone bariatric surgery become pregnant. CASE: A women, pregnant 2 years after laparoscopic gastric banding, presented with prolonged vomiting due to slippage of the gastic band resulting in gastric outlet obstruction. Parenteral feeding was initiated for 3 weeks until the patient was delivered because of a nonreassuring fetal heart rate pattern. A postnatal diagnosis of an extensive intracranial fetal hemorrhage due to maternal vitamin K deficiency was made. CONCLUSION: Although restrictive bariatric surgery is generally considered safe, we want to warn of possible severely adverse outcomes related to the intervention. In case of food intolerance, early vitamin substitution is indicated.
Sodium butyrate, a histone deacetylase inhibitor, regulates Lymphangiogenic factors in oral cancer cell line HSC-3.

AIM Tumor angiogenesis is a focus of molecularly-targeted therapies. This study investigated the effect of sodium butyrate (SB), a histone deacetylase inhibitor, on the synthesis of antiangiogenic and lymphangiogenic factors in oral squamous cell carcinoma. DESIGN Gene alterations in HSC-3 cells were assessed using cDNA microarrays before and after treatment with SB. The mRNA and protein expression of lymphangiogenic factors were also assessed by quantitative PCR, western blotting and immunocytochemistry. RESULTS Microarray analysis revealed that treatment with SB led to altered expression of angiogenesis-related gene expression. The quantitative polymerase chain reaction showed that platelet-derived growth factor-B, angiopoietin-2, vascular endothelial growth factor (VEGF)-C, and VEGFD were down-regulated. Western blotting and immunocytochemistry confirmed reduced protein synthesis of VEGFC. CONCLUSION SB inhibits expression of lymphangiogenic factors in HSC-3 cells. Within the limitations of the present study, SB may have potential as an anti-metastatic pro-drug for oral cancer.
A Significant Inhibitory Effect on Advanced Glycation End Product Formation by Catechin as the Major Metabolite of Lotus Seedpod Oligomeric Procyanidins

Several lines of evidence suggested that B-type procyanidin oligomers from lotus seedpod (LSOPC) may effectively modulate the formation of advanced glycation end products (AGEs). In vivo, LSOPC is metabolized by intestinal flora to become various kinds of phenolic compounds that possess potent antioxidant activities. However, few reports of the absorption and metabolism of LSOPC have been revealed. In the present study, rats were orally administered with LSOPC at a dose of 300 mg/kg body weight. The metabolites of LSOPC in urine were elucidated by HPLC-MS/MS analysis 24 h post-administration. Eight major metabolites were significantly increased by the administration of 300 mg/kg of LSOPC (p < 0.01). The anti-glycative activity of LSOPC and its metabolites were investigated. The results showed that LSOPC and catechin had greater anti-glycative activities than other metabolites, which were positively correlated to their carbonyl scavenging activities and antioxidant capacities.
A joint model and SOC estimation method for lithium battery based on the sigma point KF

Lithium-ion batteries have been widely used in electric vehicles (EV). The working state of the battery is very important to the safety of an EV. Online estimation of the state of charge (SOC) is essential in obtaining the battery working conditions. In order to achieve an accurate estimation of the SOC, the battery model should be adjustable when the battery is aged. A joint battery model and SOC estimation method based on the sigma point kalman filter (SPKF) is presented. A combined battery model is used to depict the relationship between the open circuit voltage (OCV) and the SOC of the battery. The main battery model parameter for estimation is the internal resistance and it is jointly estimated with the SOC online. Experimental results show that the SPKF based joint estimation method is effective.
Direct Photometric Alignment by Mesh Deformation

The choice of motion models is vital in applications like image/video stitching and video stabilization. Conventional methods explored different approaches ranging from simple global parametric models to complex per-pixel optical flow. Mesh-based warping methods achieve a good balance between computational complexity and model flexibility. However, they typically require high quality feature correspondences and suffer from mismatches and low-textured image content. In this paper, we propose a mesh-based photometric alignment method that minimizes pixel intensity difference instead of Euclidean distance of known feature correspondences. The proposed method combines the superior performance of dense photometric alignment with the efficiency of mesh-based image warping. It achieves better global alignment quality than the feature-based counterpart in textured images, and more importantly, it is also robust to low-textured image content. Abundant experiments show that our method can handle a variety of images and videos, and outperforms representative state-of-the-art methods in both image stitching and video stabilization tasks.
Flux calibration of the Herschel-SPIRE photometer

We describe the procedure used to flux calibrate the three-band submillimetre photometer in the Spectral and Photometric Imaging Receiver instrument on the Herschel Space Observatory. This includes the equations describing the calibration scheme, a justification for using Neptune as the primary calibration source, a description of the observations and data processing procedures used to derive flux calibration parameters (for converting from voltage to flux density) for every bolometer in each array, an analysis of the error budget in the flux calibration for the individual bolometers and tests of the flux calibration on observations of primary and secondary calibrators. The procedure for deriving the flux calibration parameters is divided into two parts. In the first part, we use observations of astronomical sources in conjunction with the operation of the photometer internal calibration source to derive the unscaled derivatives of the flux calibration curves. To scale the calibration curves in Jy beam^(−1) V^(−1), we then use observations of Neptune in which the beam of each bolometer is mapped using a very fine scan pattern. The total instrumental uncertainties in the flux calibration for most individual bolometers is ∼0.5 per cent, although a few bolometers have uncertainties of ∼1–5 per cent because of issues with the Neptune observations. Based on application of the flux calibration parameters to Neptune observations performed using typical scan map observing modes, we determined that measurements from each array as a whole have instrumental uncertainties of 1.5 per cent. This is considerably less than the absolute calibration uncertainty associated with the model of Neptune, which is estimated at 4 per cent.
Small plaque (digitate) parapsoriasis is an 'abortive cutaneous T-cell lymphoma' and is not mycosis fungoides.

ABOUT 100 YEARS ago, Unna et al 1 described two cases of so-called parakeratosis variegata. Brocq, 2 7 years later, saw one of Unna and colleagues' cases, as well as some similar cases, and described it as ''erythrodermies pityriasiques en plaques disseminees. '' In a 1902 article, Brocq 3 reviewed the German, French, and American literature and reported 10 cases of his own, for which he created the term parapsoriasis because of their similarities to psoriasis, seborrheic eczema, and lichen (''paralichen'' 3 ). Brocq 3 describes three major subgroups, the common features of which are (1) the long duration of the disease; (2) no reduction of general health; (3) absence of pruritus; (4) superficial localization of the process involving the upper dermis and the epidermis, leading to erythema and pityriasiform scaling; (5) resistance to topical treatment modalities; and (6) histologically round cellular infiltrate around dilated blood vessels of the papillary dermis, edema
Child and Adolescent Psychiatry and Mental Health Understanding the Agreements and Controversies Surrounding Childhood Psychopharmacology

The number of children in the US taking prescription drugs for emotional and behavioral disturbances is growing dramatically. This growth in the use of psychotropic drugs in pediatric populations has given rise to multiple controversies, ranging from concerns over off-label use and long-term safety to debates about the societal value and cultural meaning of pharmacological treatment of childhood behavioral and emotional disorders. This commentary summarizes the authors' eight main findings from the first of five workshops that seek to understand and produce descriptions of these controversies.
Folate and brain function in the elderly

Purpose of reviewOver the past several decades, folate has emerged as an important nutrient in several key conditions of concern to the elderly. Subclinical levels of folate inadequacy can have significant negative impacts on health in older individuals. Recent findingsSerum and red blood cell folate levels are associated with depression in younger individuals, but the relationship is less clear in older people. However, folate status does predict response to antidepressant treatment in older individuals. Cognitive decline and some forms of dementia, including Alzheimer's disease, are associated with lower folate levels. Supplementation with folic acid can provide cognitive benefits in some circumstances. Folic acid supplementation is generally regarded as safe; however, there remains some concern that high levels of folic acid may exacerbate the neurological consequences of a vitamin B12 deficiency. SummaryEvidence for the role of folate in depression and dementia in the aged is increasing, although there remains much about mechanisms to be determined.
Structure, function and evolution of insect flight muscle

Insects, the largest group of animals on the earth, owe their prosperity to their ability of flight and small body sizes. The ability of flight provided means for rapid translocation. The small body size allowed access to unutilized niches. By acquiring both features, however, insects faced a new problem: They were forced to beat their wings at enormous frequencies. Insects have overcome this problem by inventing asynchronous flight muscle, a highly specialized form of striated muscle capable of oscillating at >1,000 Hz. This article reviews the structure, mechanism, and molecular evolution of this unique invention of nature.
Structural Neuroplastic Change After Constraint-Induced Movement Therapy in Children With Cerebral Palsy

Research from the present laboratory with adult stroke patients showed that structural neuroplastic changes are correlated with clinical improvements due to constraint-induced movement (CI) therapy. This pilot study evaluated whether comparable changes occur in children receiving CI therapy. Ten children (6 boys) with congenital hemiparesis (mean age: 3 years, 3 months) underwent MRI scans 3 weeks before, immediately before, and immediately after receiving 3 weeks of CI therapy. Longitudinal voxel-based morphometry was performed on MRI scans to determine gray matter change. In addition, the Pediatric Motor Activity Log-Revised was administered at these time points to assess arm use in daily life before and after treatment. Children exhibited large improvements after CI therapy in spontaneous use of the more-affected arm (P < .001, d′ = 3.24). A significant increase in gray matter volume occurred in the sensorimotor cortex contralateral to the more-affected arm (P = .04); there was a trend for these changes to be correlated with motor improvement (r = 0.63, P = .063). Trends were also observed for increases in gray matter volume in the ipsilateral motor cortex (P = .055) and contralateral hippocampus (P = .1). No significant gray matter change was seen during the 3 weeks before treatment. These findings suggest that CI therapy produces gray matter increases in the developing nervous system and provide additional evidence that CI therapy is associated with structural remodeling of the human brain while producing motor improvement in patients with disabling central nervous system diseases.
Temporal dynamics of a local fish community are strongly affected by immigration from the surrounding metacommunity

A 5-year time series of annual censuses was collected from a large floodplain lake to determine how dynamics of the local fish community were affected by changes in hydrological connectivity with the surrounding metacommunity. The lake was disconnected from the metacommunity for 1 year prior to our study and remained disconnected until 3 months before our third annual census, when a flood reconnected the lake to the metacommunity. We determined how changes in connectivity affected temporal dynamics of (1) local community composition and (2) the population composition, condition, and growth of catfish, to shed light on how immigration of other species might affect local population dynamics. Before reconnection, the community was likely shaped by interactions between the local environment and species traits. The reconnection caused significant immigration and change in community composition and correlated with a significant and abrupt decline in catfish condition, growth, and abundance; effects likely due to the immigration of a competitor with a similar trophic niche: carp. The community was slow to return to its preconnection state, which may be due to dispersal traits of the fishes, and a time-lag in the recovery of the local catfish population following transient intensification of species interactions. The dynamics observed were concordant with the species sorting and mass-effects perspectives of metacommunity theory. Floods cause episodic dispersal in floodplain fish metacommunities, and so, flood frequency determines the relative importance of regional and local processes. Local processes may be particularly important to certain species, but these species may need sufficient time between floods for population increase, before the next flood-induced dispersal episode brings competitors and predators that might cause population decline. Accordingly, species coexistence in these metacommunities may be facilitated by spatiotemporal storage effects, which may in turn be regulated by flood frequency.
Inflammation in intervertebral disc degeneration and regeneration

Intervertebral disc (IVD) degeneration is one of the major causes of low back pain, a problem with a heavy economic burden, which has been increasing in prevalence as populations age. Deeper knowledge of the complex spatial and temporal orchestration of cellular interactions and extracellular matrix remodelling is critical to improve current IVD therapies, which have so far proved unsatisfactory. Inflammation has been correlated with degenerative disc disease but its role in discogenic pain and hernia regression remains controversial. The inflammatory response may be involved in the onset of disease, but it is also crucial in maintaining tissue homeostasis. Furthermore, if properly balanced it may contribute to tissue repair/regeneration as has already been demonstrated in other tissues. In this review, we focus on how inflammation has been associated with IVD degeneration by describing observational and in vitro studies as well as in vivo animal models. Finally, we provide an overview of IVD regenerative therapies that target key inflammatory players.
SU(2)(0) and OSp(2|2)(-2) WZNW models: Two current algebras, one logarithmic CFT

We show that the SU(2)0 Wess–Zumino–Novikov–Witten (WZNW) model has a hidden OSp(2|2)-2 symmetry. Both these theories are known to have logarithms in their correlation functions. We also show that, like OSp(2|2)-2, the logarithmic structure present in the SU(2)0 model is due to an underlying c = - 2 sector. We demonstrate that the quantum Hamiltonian reduction of SU(2)0 leads very directly to the correlation functions of the c=-2 model. We also discuss some of the novel boundary effects which can take place in this model.
High-Dose Erythropoietin and Hypothermia for Hypoxic-Ischemic Encephalopathy: A Phase II Trial

OBJECTIVE: To determine if multiple doses of erythropoietin (Epo) administered with hypothermia improve neuroradiographic and short-term outcomes of newborns with hypoxic-ischemic encephalopathy. METHODS: In a phase II double-blinded, placebo-controlled trial, we randomized newborns to receive Epo (1000 U/kg intravenously; n = 24) or placebo (n = 26) at 1, 2, 3, 5, and 7 days of age. All infants had moderate/severe encephalopathy; perinatal depression (10 minute Apgar <5, pH <7.00 or base deficit ≥15, or resuscitation at 10 minutes); and received hypothermia. Primary outcome was neurodevelopment at 12 months assessed by the Alberta Infant Motor Scale and Warner Initial Developmental Evaluation. Two independent observers rated MRI brain injury severity by using an established scoring system. RESULTS: The mean age at first study drug was 16.5 hours (SD, 5.9). Neonatal deaths did not significantly differ between Epo and placebo groups (8% vs 19%, P = .42). Brain MRI at mean 5.1 days (SD, 2.3) showed a lower global brain injury score in Epo-treated infants (median, 2 vs 11, P = .01). Moderate/severe brain injury (4% vs 44%, P = .002), subcortical (30% vs 68%, P = .02), and cerebellar injury (0% vs 20%, P = .05) were less frequent in the Epo than placebo group. At mean age 12.7 months (SD, 0.9), motor performance in Epo-treated (n = 21) versus placebo-treated (n = 20) infants were as follows: Alberta Infant Motor Scale (53.2 vs 42.8, P = .03); Warner Initial Developmental Evaluation (28.6 vs 23.8, P = .05). CONCLUSIONS: High doses of Epo given with hypothermia for hypoxic-ischemic encephalopathy may result in less MRI brain injury and improved 1-year motor function.
Weighted-Voronoi-Diagram Based Codebook Design against Passive Eavesdropping for MISO Systems

Conventional methods of codebook design in limited-feedback multi-antenna systems aim to quantize the single-user channel but without considering secrecy requirements. Thus, the information leakage is inevitably aggravated due to the eavesdropping behaviors in limited-feedback multiple-input single-output single-antenna- eavesdropper (MISOSE) systems. To reduce the information leakage without any extra cost in antenna resources and feedback overheads, the statistical distribution of the channel matrix of both the legitimate receiver and the eavesdropper needs to be jointly exploited. Accordingly, this paper studies the novel codebook design method by further utilizing the statistical relationship between channel direction vectors and codeword vectors. Particularly, we formulate a codeword update mechanism on the weighted Voronoi diagram (WVD) where weighted codeword vectors are iteratively updated for improving the non-zero secrecy rates. Ultimately, an implementing algorithm is devised to determine those codewords with both of the secrecy-rate gains and beamforming gains. Simulation results further validate the superiority of our proposed method over conventional single-user-oriented codebooks in the respect of both average secrecy rates and average rates.
seroprevalence of HSV-2 in children : seroprevalence in childhood is often used to estimate the incidence of intrauterine and neonatal HSV-2 infections

A Sauerbrei (Andreas.Sauerbrei@med.uni-jena.de)1, S Schmitt2, T Scheper3, A Brandstädt4, S Saschenbrecker3, M Motz5, E Soutschek5, P Wutzler1 1. Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Clinic, Jena, Germany 2. SanofiPasteur MSD, Leimen, Germany 3. Institute of Experimental Immunology (affiliated to Euroimmun AG), Lübeck, Germany 4. Institute of Medical Statistics, Computer Sciences and Documentation, Jena University Clinic, Jena, Germany 5. Mikrogen, Neuried, Germany