Miracle-dz/UniFAR-FTUs huggingface dataset:
Cancer Therapeutics Insights Tenovin-D 3 , a Novel Small-Molecule Inhibitor of Sirtuin SirT 2 , Increases p 21 ( CDKN 1 A ) Expression in a p 53-Independent Manner

While small-molecule inhibitors of class I/II histone deacetylases (HDAC) have been approved for cancer treatment, inhibitors of the sirtuins (a family of class III HDACs) still require further validation and optimization to enter clinical trials. Recent studies show that tenovin-6, a small-molecule inhibitor of sirtuins SirT1 and SirT2, reduces tumor growth in vivo and eliminates leukemic stem cells in amurinemodel for chronic myelogenous leukemia. Here, we describe a tenovin analogue, tenovin-D3, that preferentially inhibits sirtuin SirT2 and induces predicted phenotypes for SirT2 inhibition. Unlike tenovin-6 and in agreement with its weak effect on SirT1 (a p53 deacetylase), tenovin-D3 fails to increase p53 levels or transcription factor activity. However, tenovin-D3 promotes expression of the cell-cycle regulator and p53 target p21 (CDKN1A) in a p53-independent manner. Structure–activity relationship studies strongly support that the ability of tenovin-D3 to inhibit SirT2 contributes to this p53-independent induction of p21. The ability of tenovin-D3 to increasep21mRNAandprotein levels is sharedwith class I/IIHDAC inhibitors currentlyused in the clinic and therefore suggests that SirT2 inhibition and class I/II HDAC inhibitors have similar effects on cell-cycle progression. Mol Cancer Ther; 1–9. 2013 AACR.
The Effect of Daily Fluoride Mouth Rinsing on Enamel Erosive/Abrasive Wear in situ

It is not known whether application of fluoride agents on enamel results in lasting resistance to erosive/abrasive wear. We investigated if one daily mouth rinse with sodium fluoride (NaF), stannous fluoride (SnF2) or titanium tetrafluoride (TiF4) solutions protected enamel against erosive/abrasive wear in situ (a paired, randomised and blind study). Sixteen molars were cut into 4 specimens, each with one amalgam filling (measurement reference surface). Two teeth (2 × 4 specimens) were mounted bilaterally (buccal aspects) on acrylic mandibular appliances and worn for 9 days by 8 volunteers. Every morning, the specimens were brushed manually with water (30 s) extra-orally. Then fluoride solutions (0.4% SnF2 pH 2.5; 0.15% TiF4 pH 2.1; 0.2% NaF pH 6.5, all 0.05 m F) were applied (2 min). Three of the specimens from each tooth got different treatment, and the fourth served as control. At midday, the specimens were etched for 2 min in 300 ml fresh 0.01 m hydrochloric acid and rinsed in tap water. This etch procedure was repeated in the afternoon. Topographic measurements were performed by a white-light interferometer. Mean surface loss (±SD) for 16 teeth after 9 days was: SnF2 1.8 ± 1.9 µm, TiF4 3.1 ± 4.8 µm, NaF 26.3 ± 4.7 µm, control 32.3 ± 4.4 µm. Daily rinse with SnF2, TiF4 and NaF resulted in 94, 90 and 18% reduction in enamel erosive/abrasive wear, respectively, compared with control (p < 0.05). The superior protective effect of daily rinse with either stannous or titanium tetrafluoride solutions on erosive/abrasive enamel wear is promising.
Is it possible to exclude a diagnosis of myocardial damage within six hours of admission to an emergency department? Diagnostic cohort study

Abstract Objective: To assess the clinical efficacy and accuracy of an emergency department based six hour rule-out protocol for myocardial damage. Design: Diagnostic cohort study. Setting: Emergency department of an inner city university hospital. Participants: 383 consecutive patients aged over 25 years with chest pain of less than 12 hours' duration who were at low to moderate risk of acute myocardial infarction. Intervention: Serial measurements of creatine kinase MB mass and continuous ST segment monitoring for six hours with 12 leads. Main outcome measure: Performance of the diagnostic test against a gold standard consisting of either a 48 hour measurement of troponin T concentration or screening for myocardial infarction according to the World Health Organization's criteria. Results: Outcome of the gold standard test was available for 292 patients. On the diagnostic test for the protocol, 53 patients had positive results and 239 patients had negative results. There were 18 false positive results and one false negative result. Sensitivity was 97.2% (95% confidence interval 95.0% to 99.0%), specificity 93.0% (90.0% to 96.0%), the negative predictive value 99.6%, and the positive predictive value 66.0%. The positive likelihood ratio was 13.9 and the negative likelihood ratio 0.03. Conclusions: The six hour rule-out protocol for myocardial infarction is accurate and efficacious. It can be used in patients presenting to emergency departments with chest pain indicating a low to moderate risk of myocardial infarction. What is already known on this topic Many patients with chest pain in emergency departments indicating a low to moderate risk of myocardial infarction are admitted to rule out myocardial damage Some 6% of those discharged have undiagnosed myocardial damage What this study adds An emergency department based chest pain assessment unit protocol to rule out myocardial damage is sensitive enough to allow safe discharge of patients at low to moderate risk of myocardial infarction within six hours Such units can also reduce the number of patients admitted unnecessarily
Diabetes risk, diagnosis, and control: do psychosocial factors predict hemoglobin A1c defined outcomes or accuracy of self-reports?

OBJECTIVE To evaluate the accuracy of self-reported diabetes among multi-ethnic older adults by psychosocial factors and assess predictors of diabetes risk, diagnosis, and control. DESIGN AND METHODS The 2006 Health and Retirement Study (N=5,594) was used to determine agreement between self-reported diabetes and measured diabetes (HbA1c> or = 6.5%) by age, sex, race/ethnicity, nativity, education, health insurance coverage, body mass index, depressive symptoms, and prior report of racial discrimination. We also examined associations between these factors and pre-diabetes (HbA1c > or = 6.0-<6.5%) among individuals without diabetes, and those with undiagnosed and poorly controlled (HbA1c > or = 8.0%) diabetes. RESULTS Accuracy of self-reported diabetes was good (ie, sensitivity > or = 80% and specificity > or = 95%) among all demographic subgroups and across most social strata. Among those who reported racial discrimination, sensitivity of self-reported diabetes was lower among Blacks who reported racial discrimination in comparison to Blacks who did not report racial discrimination (82.7% vs 89.0%) an association that was marginally statistically significant (P=.05). Blacks and Hispanics had higher odds of pre-diabetes, undiagnosed diabetes, and poor glycemic control. CONCLUSIONS Self-reported diabetes corresponded well with HbAlc assessed disease for all social strata examined in this sample of multi-ethnic older adults. Blacks with a history of racial discrimination may be less likely to know diabetes status.
Investigations on anti-jamming method for 77GHz automotive millimeter-wave radar

LSFCW modulation system, presented by this paper based on LFMCW, is more suitable for 77GHz millimeter-wave radar system to identify the target, which takes advantages of the modulation of FSK and LFMCW; and implements multiple target real-time detection ability whether stationary or movement. By means of the chip of ADF4159 from ANALOG DEVICES supporting the modulation of FSK and LFMCW, the fast sawtooth sweep frequency is implemented from 12.765GHz to 12.815GHz; the function of the automotive millimeter-wave radar frequency hopping is realized by means of the frequency of FSK set by properly.
The Biophysics of Radiofrequency Catheter Ablation in the Heart: The Importance of Temperature Monitoring

Radiofrequency (RF) catheter ablation is a technique whereby high frequency alternating electrical current with frequencies of 350 kHz to 1 MHz is delivered through eiectrode catheters to myocardial tissue creating a thermal lesion. The mechanism by which RF current heats tissue is resistive (or ohmic) heating of a narrow rim (< 1 mm) of tissue that is in direct contact with the electrode Deeper tissue planes are then heated by conduction from the small region of volume heating. Heat is dissipated from the region by further heat conduction into normothermic tissue, and by heat convection via the circulating blood pool and larger coronary vessels. The lesion size is proportional to the temperature at the electrode‐tissue interface (which is also a function of power level if electrical factors remain constant), and to the size of the electrode. At temperatures above 100°C, boiling occurs at the electrode‐tissue contact point resulting in a rapid rise in electrical impedance. Therefore, a theoretical maximum lesion size exists for any given electrode geometry. Other factors that are important for RF lesion formation incude electrode‐tissue contact pressure and duration of RF delivery. Temperature rises monoexponentially, and duration of energy delivery should be at least 35 to 45 seconds to approach steady state.
Effect of Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on Patients Following Ablation of Atrial Fibrillation

Background and Objectives It is known that angiotensin converting enzyme inhibitors and angiotensin II type 1 receptor blockers (ACEIs and ARBs, respectively) are effective in preventing atrial fibrillation (AF) in high-risk patients. However, it is not known whether ACEIs and ARBs are effective in preventing the recurrence of AF after catheter ablation. Subjects and Methods One hundred fifty-two patients (mean age, 57±10 years; M : F=94 : 58) who underwent catheter ablation due to drug-refractory paroxysmal (mean age, 57±10 years; M : F=58 : 43) or persistent AF (mean age, 56±10 years; M : F=36 : 15) were enrolled. We compared the recurrence rates between the groups with and without ACEIs or ARBs use in paroxysmal and persistent AF. The mean duration of follow-up was 18±14 months. Results The overall recurrence rate after ablation therapy was 26% (n=39). The recurrence rate was significantly decreased in the patients with persistent AF with the use of ACEIs or ARBs (12.1% vs. 61.1%, p<0.01), but this difference was not observed in the patients with paroxysmal AF (24.2% vs. 22.9%, p=0.87). In patients with persistent AF with and without recurrence, the size of the left atrium (44.2±8.4 mm vs. 44.3±5.8 mm, respectively, p=0.45) and the ejection fraction (62±6.5% vs. 61.5±6.2%, respectively, p=0.28) were not significantly different. In multivariate analysis, the use of ACEIs or ARBs was independently associated with recurrence after adjusting for the size of the left atrium and the ejection fraction {odds ratio (OR)=0.078, 95% confidence interval (CI)=0.02-0.35, p<0.01}. Conclusion ACEIs and ARBs were shown to be effective in preventing AF recurrence after catheter ablation in patients with persistent AF.
Modeling and Optimization of Edge Dislocation Stressors

Dislocation stressors in the source and drain build the tensile stress field in the channel of nMOSFET. An analytic model of the strain/stress field induced by the edge dislocation is presented. The model is used for stress optimization of the dislocation stressors in the nMOSFET channel. The accuracy of the model is similar to that of the finite element simulation. The closed-form solution provides a physical insight into the dislocation stressor. The analytic solution shows that shallower dislocations generate a larger tensile stress at the edge of the channel near the virtual source. For a given dislocation depth, an optimal distance of the dislocation core from the edge is required to generate the maximum tensile stress at the channel edge.
Absence of effect of sertraline on time-based sensitization of cognitive impairment with haloperidol.

UNLABELLED This double-blind, randomized, placebo-controlled study evaluated the effects of haloperidol alone and haloperidol plus sertraline on cognitive and psychomotor function in 24 healthy male subjects. METHOD All subjects received placebo on Day 1 and haloperidol 2 mg on Days 2 and 25. From Days 9 to 25, subjects were randomly assigned to either sertraline (12 subjects) or placebo (12 subjects); the sertraline dose was titrated from 50 to 200 mg/day from Days 9 to 16, and remained at 200 mg/day for the final 10 days of the drug administration period. Cognitive function testing was performed before dosing and over a 24-hour period after dosing on Days 1, 2, and 25. RESULTS Impairment of cognitive function was observed 6 to 8 hours after administration of haloperidol on Day 2 but was not evident 23 hours after dosing. When single-dose haloperidol was given again 25 days later, greater impairment with earlier onset was noted in several tests in both treatment groups, suggesting enhancement of this effect. There was no indication that sertraline exacerbated the impairment produced by haloperidol since an equivalent effect also occurred in the placebo group. Three subjects (2 on sertraline and 1 on placebo) withdrew from the study because of side effects. Ten subjects in each group reported side effects related to treatment. The side effect profiles of sertraline and of placebo were similar. CONCLUSION Haloperidol produced a clear profile of cognitive impairment that was not worsened by concomitant sertraline administration.
Maus-Tratos Infantis: lesões que podem ser identificadas por Cirurgiões-Dentistas / Child Abuse: Lesions that can be identified by Dentists

Os maus-tratos infantis representam um grave problema de saúde pública. Os profissionais de saúde, em especial os cirurgiões-dentistas, possuem um importante papel na identificação dessas lesões por manterem contato direto com a criança vítima. O objetivo dessa pesquisa foi revisar a literatura científica buscando as lesões relacionadas ao AFI que podem ser identificadas pelo cirurgião-dentista, ressaltando o papel desses profissionais na detecção e notificação de casos suspeitos. Foram pesquisados artigos científicos, em inglês e português, disponíveis nas bases de dados PUBMED, Scielo e Google Acadêmico. Utilizaram-se como descritores: maus-tratos infantis, cirurgião-dentista, pessoal de saúde. Os resultados demonstraram que a negligência e o abuso físico são as mais frequentes injurias encontradas contra a criança. O cirurgião-dentista pode identificar várias lesões orais como hematomas, lacerações de lábio, fraturas, avulsões, equimoses, queimaduras, arranhões e lacerações de freio lingual e bucal. Os sinais surgem preferencialmente na região da língua, dos lábios, do palato duro ou mole, da gengiva, do freio labial ou da mucosa. Esta revisão torna-se útil por auxiliar os profissionais de saúde na compreensão dos sinais e sintomas que evidenciam situações de maus-tratos infantis.
Simplified Voltage Notch Filler for Interactive Uninterruptible Power Supplies

There are three types of Static Uninterruptible Power Supplies (UPS): off-line, interactive and double-conversion. The last one protects the load against all types of line disturbances but it is the most expensive and the one with the lowest efficiency. On the other hand, off-line and interactive UPS have higher efficiency and lower cost, but they show an important drawback: a switching time from normal mode to stored-energy mode. As a consequence, there is a notch in the UPS output voltage during this switching time. In a previous paper [1], authors proposed a method for filling these voltage notches with a sinusoidal waveform generated by a switch-mode converter. In this one, a simplified notch filler is proposed. It consists of two capacitors charged one with positive and the other with negative voltage. If the fault occurs in the positive period, the positive charged capacitor is connected to the load. This connection is then modulated in order to obtain a sinusoidal waveform at the load. In the negative period, the other capacitor is used in the same way.
Primary Hepatic Osteosarcoma: A Rare Cause of Primary Liver Tumor

Introduction Extraosseous osteosarcomas are rare, accounting for approximately 4% of all osteosarcomas. A literature review yields very few cases of osteosarcoma primarily arising from the hepatic parenchyma. Case Report This report describes a case of a man in his 50s with a history of hepatitis C and cirrhosis who presented with 5 days of progressive right upper quadrant pain. Magnetic resonance imaging of the abdomen and pelvis demonstrated a 4.4 cm X 4.8 cm X 4.8 cm right hepatic lobe mass with a large area of necrosis and peripheral enhancement. The subsequent liver biopsy showed few cores of tumor composed of fibroblastic malignant cells producing lace-like osteoid matrix. Osteosarcomatous foci in other parts of the body were excluded by performing extensive physical examination, radiologic imaging, and biopsy. Hence, a primary osteosarcoma was diagnosed. The patient underwent portal vein embolization in preparation for a surgical resection of the right liver lobe. He was admitted six weeks after the embolization for dyspnea and abdominal distension and expired due to abdominal hematoma and pulmonary embolism. Conclusion Based on the rarity, lack of consensus in treatment, and dismal prognosis, extraosseous osteosarcoma should be considered a separate entity from osseous osteosarcoma. More data and research are needed in this rare and understudied malignancy.
De novo lipogenesis in the liver in health and disease: more than just a shunting yard for glucose

Hepatic de novo lipogenesis (DNL) is the biochemical process of synthesising fatty acids from acetyl‐CoA subunits that are produced from a number of different pathways within the cell, most commonly carbohydrate catabolism. In addition to glucose which most commonly supplies carbon units for DNL, fructose is also a profoundly lipogenic substrate that can drive DNL, important when considering the increasing use of fructose in corn syrup as a sweetener. In the context of disease, DNL is thought to contribute to the pathogenesis of non‐alcoholic fatty liver disease, a common condition often associated with the metabolic syndrome and consequent insulin resistance. Whether DNL plays a significant role in the pathogenesis of insulin resistance is yet to be fully elucidated, but it may be that the prevalent products of this synthetic process induce some aspect of hepatic insulin resistance.
Multiscale Image Segmentation Using Bayesian Optimum Statistical Estimation

The wavelet domain hidden Markov tree (WHMT) model can decompose the original image into a multiscale and multiband representation. In traditional methods, each WHMT model has to be trained with a single texture image, i.e., each texture is represented by a corresponding WHMT model. This method is memory consuming and do not work for unknown textures. More importantly, the model training of the wavelet domain hidden Markov tree does not take into consideration of the classification likelihood of the foreground and background observations in an optimum sense. In this paper, we develop a probabilistic approach to learn the a priori distribution of foreground objects and backgrounds of WHMT based on the Bayesian optimum statistical classifiers. Instead of computing the class labels of each pixel in the image, we only compute the likelihood of each pixel that belongs to foreground and background, which is then assigned to the classification likelihood of WHMT model. The robustness and accuracy of the proposed algorithm is demonstrate by using four real world horse image come from the benchmark of Weizmann Horse database.
Best Location and Reader Role in Usage of Emergency Manuals During Critical Events: Experienced Emergency Manual Users’ Opinion

Introduction Emergency manuals (EM) are an essential component of the response to critical events by healthcare providers, and there is strong evidence to support the benefits of utilizing EMs in crisis management. Despite the widespread utilization of EMs by providers, there is currently no national standardized protocol for EM usage, accompanied by a deficit in research on EM usage. To develop a protocol for EM utilization, factors such as the best location for EMs to be placed and the EM reader role must be determined. Methods Anesthesiologists with experience in EM use from seven hospitals participated in a survey questionnaire that was distributed to all participants through WeChat using the WenJianxen software. Survey response numbers were converted into percentages and were used to summarize the categorical variables. Results Results showed the best location of EMs used during critical events was in the anesthesia station of the operating room and that the preferred reader of EMs during critical events is the senior physician. Conclusion Our study suggests that placing EMs within close reach of the health care providers may be most efficient and that the reader of EMs should be the leader of the clinical team. These results may be applicable to the development and implementation of a national protocol for EM usage.
Geographic Distribution Insect-Specific Viruses with Wide Negevirus : a Proposed New Taxon of

Published Ahead of Print 19 December 2012. 2013, 87(5):2475. DOI: 10.1128/JVI.00776-12. J. Virol. Lipkin and Robert B. Tesh Amelia P. A. Travassos da Rosa, Scott C. Weaver, W. Ian Vázquez González, Andrew D. Haddow, Douglas M. Watts, Ana Thomas G. Wood, Vsevolod Popov, Rodion Gorchakov, Guzman, Farooq Nasar, Nazir Savji, Shannan L. Rossi, Hilda Nikos Vasilakis, Naomi L. Forrester, Gustavo Palacios, Geographic Distribution Insect-Specific Viruses with Wide Negevirus: a Proposed New Taxon of
A bi-linear optimization model for collaborative energy management in smart grid

This paper addresses the residential energy cost optimization problem in smart grid. More precisely, it proposes an approximate optimization model and evaluates its performance with an exact model. Previously, we developed an exact model which considers energy trading between the households in the microgrid. In the proposed approach, all households determine the microgrid energy price and quantity in collaboration with others. The complexity of the model was further increased when the unfair cost distribution problem among the households was addressed. The final model is a multi-objective non-convex Mixed Integer Non-Linear Programming (MINLP) problem. Its complexity is NP-hard which means that using the resulting solution is not practical because the solution times increase exponentially according to the increase in the problem size. To tackle this issue, this paper proposes an approximate model by using bi-linear optimization to reduce the computational complexity. The bilinear model breaks down the MINLP model into multiple Mixed Integer Linear Programming (MILP) modules and iteratively solves these modules until it meets the terminating criterion. Results show that solution times of the bi-linear model are very low compared to the exact model. Moreover, 97% of the solutions generated by the bi-linear model are optimal solutions. The proposed model maintains Pareto optimality which means that no households will be worse off to improve the cost of others. The final solution minimizes the total cost of the households in the microgrid.
An efficient algorithm for infallible polynomial complex root isolation

Applying the principle of the argument to rectangles provides an efficient algorithm for polynomial complex root isolation. For example, the roots of a real integral polynomial of degree 10 (with 10-bit coefficients) can be isolated in about 1 second. Furthermore, although the algorithm is not designed for efficient refinement of isolating rectangles, it does nevertheless refine all c]f these rectangles to width 10-50 in less than 4 minutes.