Miracle-dz/UniFAR-FTUs huggingface dataset:
Adherence of Mycoplasma gallisepticum involves variable surface membrane proteins

Adherence of Mycoplasma gallisepticum to erythrocytes was examined by colony immunoblotting, detergent phase fractionation, trypsin treatment, comparison of protein profiles, and comparison of erythrocyte-bound mycoplasma protein fractions of hemadsorption-positive and -negative mutants. The binding of M. gallisepticum to chicken or human erythrocytes was found to be mediated via surface-exposed membrane proteins undergoing high-frequency phase variation.
Sustainability and Technical Progress

A rigorous model connects together the following three basic concepts: (1) 'sustainability'--measuring the generalized future power of an economy to consume over time; (2) 'green NNP'--meaning a current measure of national income that subtracts off from GNP not just depreciation of capital but also, more generally, depletion of environmental assets evaluated at current efficiency prices; and (3) 'technological progress'--meaning a projection onto the future of the so-called 'Solow residual. ' A simple general formula is derived. Some crude calculations suggest a possibly strong effect of the residual, which hints that the author's best present estimates of long-term sustainability may be largely driven by predictions of future technological progress. Copyright 1997 by The editors of the Scandinavian Journal of Economics.
An Intelligent Hand Gesture Extraction and Recognition System for Home Care Application

This paper proposes a hand gesture extraction method. Based on motion detection and feature recognition, an intelligent hand gesture extraction method is achieved. It is possible to apply in most of homecare system, especially those patients without the ability to speak well. the system is also can apply in intelligent commercial devices control, such as television and light.
Shallow Water Carbonate Sediments of the Galรกpagos Archipelago: Ecologically Sensitive Biofacies in a Transitional Oceanographic Environment

Shallow water carbonate producing organisms are directly controlled by their local oceanography. As a result, long-term environmental signals—stemming from the breakdown of calcareous organisms—can be read from time-averaged carbonate sediments. To better understand these complex biophysical interactions, it is important to study carbonate development within oceanographic transition zones and environments affected by disturbances, such as the El Niño—Southern Oscillation (ENSO). This dissertation represents the first investigation into modern shallow water, soft sediment, carbonate environments of the Galápagos Archipelago, eastern tropical Pacific (ETP). This region is notable for straddling an oceanographic transition zone from tropical oligotrophic to temperate eutrophic—caused by high nutrient and low pH upwelling—and for being directly impacted by ENSO. A top-down
Do Metadata Models meet IQ Requirements?

Research has recognized the importance of analyzing information quality (IQ) for many diierent applications: The success of data integration greatly depends on the quality of the individual data. In statistical applications poor data quality often leads to wrong conclusions. High information quality is literally a vital property of hospital information systems. Poor data quality of stock price information services can lead to economically wrong decisions. Several projects have analyzed this need for IQ metadata and have proposed a set of IQ criteria or attributes which can be used to properly assess information quality. In this paper we survey and compare these approaches. In a second step we take a look at existing prominent proposals of metadata models, especially those on the Internet. Then, we match these models to the requirements of information quality modeling. Finally, we propose a quality assurance procedure for the assurance of metadata models.
Spatial and temporal variability of sea level rise hot spots over the eastern United States

Regional sea level rise (SLR) acceleration during the past few decades north of Cape Hatteras has commonly been attributed to weakening Atlantic Meridional Overturning Circulation, although this causal link remains debated. In contrast to this pattern, we demonstrate that SLR decelerated north of Cape Hatteras and accelerated south of the Cape to >20 mm/yr, > 3 times the global mean values from 2011 to 2015. Tide gauge records reveal comparable short‐lived, rapid SLR accelerations (hot spots) that have occurred repeatedly over ~1500 km stretches of the coastline during the past 95 years, with variable latitudinal position. Our analysis indicates that the cumulative (time‐integrated) effects of the North Atlantic Oscillation determine the latitudinal position of these SLR hot spots, while a cumulative El Niño index is associated with their timing. The superposition of these two ocean‐atmospheric processes accounts for 87% of the variance in the spatiotemporal pattern of intradecadal sea level oscillations.
Large area three-dimensional photonic crystals with embedded waveguides

Three-dimensional photonic crystals are attractive for very compact waveguide devices. A novel interferometric lithography technique for fabricating three-dimensional photonic crystals is presented, which allows for independent dimensional control of each axis of the crystal. Previous interferometric approaches using 3, 4, 5, or more beams have inherent constraints between the lattice constants and the exposure wavelength. With this new technique, it is possible to control each individual crystal lattice constant largely independent of the exposure wavelength, vastly increasing the available parameter space. Both mathematical models and experimentally realized three-dimensional photonic crystals, over 2 cm2 in size and up to 12 μm, are presented. Photonic crystals with integrated waveguides are of particular significance. A new approach to fabricating waveguides embedded in a three-dimensional photonic crystal is also presented. This approach uses multiple-exposure wavelengths, with one longer wavelength propagating throughout the photoresist for the photonic crystal fabrication and another shorter highly absorptive wavelength for the waveguide fabrication. This new approach to waveguide fabrication leads itself to scalable manufacturing using standard semiconductor lithography equipment.Three-dimensional photonic crystals are attractive for very compact waveguide devices. A novel interferometric lithography technique for fabricating three-dimensional photonic crystals is presented, which allows for independent dimensional control of each axis of the crystal. Previous interferometric approaches using 3, 4, 5, or more beams have inherent constraints between the lattice constants and the exposure wavelength. With this new technique, it is possible to control each individual crystal lattice constant largely independent of the exposure wavelength, vastly increasing the available parameter space. Both mathematical models and experimentally realized three-dimensional photonic crystals, over 2 cm2 in size and up to 12 μm, are presented. Photonic crystals with integrated waveguides are of particular significance. A new approach to fabricating waveguides embedded in a three-dimensional photonic crystal is also presented. This approach uses multiple-exposure wavelengths, with one longer wavelength .
A greedy randomized adaptive search procedure applied to the clustering problem as an initialization process using K-Means as a local search procedure

We present a new approach for Cluster Analysis based on a Greedy Randomized Adaptive Search Procedure (GRASP), with the objective of overcoming the convergence to a local solution. It uses a probabilistic greedy Kaufman initialization to get initial solutions and K-Means as a local search algorithm. The approach is a new initialization one for K-Means. Hence, we compare it with some typical initialization methods: Random, Forgy, Macqueen and Kaufman. Our empirical results suggest that the hybrid GRASP - K-Means with probabilistic greedy Kaufman initialization performs better than the other methods with improved results. The new approach obtains high quality solutions for eight benchmark problems.
A Modular Algorithm for Computing the Characteristic Polynomial of an Integer Matrix in Maple.

Let A be an n×n matrix of integers. In this paper we present details of our Maple implementation of a modular method for computing c(x), the characteristic polynomial of A. Our implementation considers several different representations for the primes, including the use of double precision floats. The algorithm presently implemented in Maple releases 7–9 is the Berkowitz algorithm [2, 1]. We present some timings comparing the two methods on a 364×364 matrix arising from an application in combinatorics from Quaintance [6]. One way to compute the characteristic polynomial of A is to evaluate the characteristic matrix at n points, compute n determinants of integer matrices, then interpolate to obtain the characteristic polynomial. The determinants of the integer matrices can be computed using a fraction-free Gaussian elimination algorithm (see Chapter 9 of Geddes et. al [4]) in O(n3) integer multiplications and divisions. This approach will lead to an algorithm that requires O(n4) integer operations. Another algorithm is the “Berkowitz” algorithm [2]. It is a division free algorithm and thus can be used to compute the characteristic polynomial of a matrix over any commutative ring R. It does O(n4) multiplications in R. In [1], Abdeljaoued described a Maple implementation of a sequential version of the Berkowitz algorithm and compared it with the interpolation method and other methods. His implementation improves with sparsity to O(n3) multiplications when the matrix has O(n) non-zero entries.
gadd153/Chop10, a potential target gene of the transcriptional repressor ATF3

Recently, we demonstrated that the function of ATF3, a stress-inducible transcriptional repressor, is negatively regulated by a bZip protein, gadd153/Chop10. In this report, we present evidence that ATF3 can repress the expression of its own inhibitor, gadd153/Chop10. First, ATF3 represses a chloramphenicol acetyltransferase reporter gene driven by the gadd153/Chop10 promoter when assayed by a transfection assay in vivo and a transcription assay in vitro. Second, the gadd153/Chop10 promoter contains two functionally important binding sites for ATF3: an AP-1 site and a C/EBP-ATF composite site, a previously unidentified binding site for ATF3. The absence of either site reduces the ability of ATF3 to repress the promoter. Third, overexpression of ATF3 by transient transfection results in a reduction of the endogenous gadd153/Chop10 mRNA level. Fourth, as described previously, ATF3 is induced in the liver upon CCl4 treatment. Intriguingly, we show in this report that gadd153/Chop10 mRNA is not present in areas where ATF3 is induced. Taken together, these results strongly suggest that ATF3 represses the expression of gadd153/Chop10. The mutual negative regulation between ATF3 and gadd153/Chop10 is discussed.
Fairytale Child Chatbot

WWW home page: http://ufal.mff. cuni.cz/rudolf-rosa Abstract: Fairytale Child (Pohadkove ditˇ e) is a simple chatbot trying to simulate a curious child. It asks the user to tell a fairy tale, often interrupting to ask for details and clarifications. However, it remembers what it was told and tries to show it if possible. The chatbot can communi- cate in Czech and in English. It analyzes the morphol- ogy of each sentence produced by the user with natural language processing tools, tries to identify potential ques- tions to ask, and then asks one. A morphological gener- ator is employed to generate correctly inflected sentences in Czech, so that the resulting sentences sound as natural as possible.
Time-action profile of the long-acting insulin analog insulin glargine (HOE901) in comparison with those of NPH insulin and placebo.

OBJECTIVE To study the pharmacodynamic properties of the subcutaneously injected long-acting insulin analog HOE901 (30 microg/ml zinc) in comparison with those of NPH insulin and placebo. RESEARCH DESIGN AND METHODS In this single-center double-blind euglycemic glucose clamp study, 15 healthy male volunteers (aged 27 +/- 4 years, BMI 22.2 +/- 1.8 kg/m2) received single subcutaneous injections of 0.4 U/kg body wt of HOE901, NPH insulin, or placebo on 3 study days in a randomized order. The necessary glucose infusion rates (GIRs) to keep blood glucose concentrations constant at 5.0 mmol/l were determined over a 30-h period after administration. RESULTS The injection of HOE901 did not induce the pronounced peak in metabolic activity observed with NPH insulin (GIRmax 5.3 +/- 1.1 vs. 7.7 +/- 1.3 mg x kg(-1) x min(-1)) (P < 0.05); after an initial rise, metabolic activity was rather constant over the study period. This lack of peak was confirmed by a lower glucose consumption in the first 4 h after injection (area under the curve from 0 to 4 h [AUC(0-4 h)] 1.02 +/- 0.34 vs. 1.48 +/- 0.34 g/kg) (P < 0.001) with HOE901, as compared with NPH insulin. In this single-dose study, the metabolic effect measured over a period of 30 h was lower with HOE901 than with NPH insulin (AUC(0-30 h) 7.93 +/- 1.82 vs. 9.24 +/- 1.29 g/kg) (P < 0.05). CONCLUSIONS This study shows that the soluble long-acting insulin analog HOE901 induces a smoother metabolic effect than NPH insulin, from which a better substitution of basal insulin requirements may follow.
An equation characterizing multi‐heavy‐metal sorption onto bentonite, forest soil and spruce bark

Abstract An empirical equation was developed to quantitatively describe heavy metal sorption in ternary systems of lead (Pb), copper (Cu) and cadmium (Cd). The three sorbants investigated were bentonite, forest soil and spruce bark. This multi‐sorption equation is based on three assumptions: the relationship between sorption and initial heavy metal concentration fits a power curve; the presence of one heavy metal proportionately reduces the sorption curve of another heavy metal; and the competition between two heavy metals is independent of the presence of other heavy metals. The multi‐sorption equation modeled sorption in ternary systems to a regression fit greater than 0.96. The data required for the equation were generated from a technically straightforward and quick laboratory program involving batch adsorption tests.
Towards a unified top-down design flow for fully differential logic blocks with improved speed and noise immunity

A new top-down design flow (RTL-to-GDSII) is proposed for achieving high-performance and noise-immune designs consisting of differential logic blocks. The differential building blocks are based on the current-mode logic (CML), which offers true differentiality with low-swing signalling, switching-independent constant power dissipation and very high-speed operation. The goal of this flow is to allow effective cancellation of inductive and capacitive noise in high-speed on-chip interconnect lines using a simple generic interconnect architecture.
Tetrapyrrole Metabolism in Arabidopsis thaliana

Higher plants produce four classes of tetrapyrroles, namely, chlorophyll (Chl), heme, siroheme, and phytochromobilin. In plants, tetrapyrroles play essential roles in a wide range of biological activities including photosynthesis, respiration and the assimilation of nitrogen/sulfur. All four classes of tetrapyrroles are derived from a common biosynthetic pathway that resides in the plastid. In this article, we present an overview of tetrapyrrole metabolism in Arabidopsis and other higher plants, and we describe all identified enzymatic steps involved in this metabolism. We also summarize recent findings on Chl biosynthesis and Chl breakdown. Recent advances in this field, in particular those on the genetic and biochemical analyses of novel enzymes, prompted us to redraw the tetrapyrrole metabolic pathways. In addition, we also summarize our current understanding on the regulatory mechanisms governing tetrapyrrole metabolism. The interactions of tetrapyrrole biosynthesis and other cellular processes including the plastid-to-nucleus signal transduction are discussed.
Genomic analysis of Skermanella stibiiresistens type strain SB22T

Members of genus Skermanella were described as Gram-negative, motile, aerobic, rod-shaped, obligate-heterotrophic bacteria and unable to fix nitrogen. In this study, the genome sequence of Skermanella stibiiresistens SB22T is reported. Phylogenetic analysis using core proteins confirmed the phylogenetic assignment based on 16S rRNA gene sequences. Strain SB22T has all the proteins for complete glycolysis, tricarboxylic acid cycle and pentose phosphate pathway. The RuBisCO encoding genes cbbL1S1 and nitrogenase delta subunit gene anfG are absent, consistent with its inability to fix carbon and nitrogen, respectively. In addition, the genome possesses a series of flagellar assembly and chemotaxis genes to ensure its motility.
Noncoherent Decision Feedback Multiuser Detection for Nonorthogonal Multipulse Modulation

| The problem of noncoherent multiuser detection for nonorthogonal multipulse modulation (NMM) over the Gaussian multiuser channel was studied in [1]. In that work, the idea of noncoherent decorrelation for NMM was introduced and post-decorrelative detectors were derived and analyzed. In this paper, we introduce the concept of noncoherent decision feedback that forms the basis for another set of solutions to the same problem. As in coherent decision feedback, the users are detected in a pre-determined order so that the decision for a particular user can take advantage of the decisions already made for previous users. In contrast to coherent decision feedback however, the feedforward and feedback transformations in the noncoherent case are themselves functions of the matched lter outputs so that they are randomly time-varying from symbol-to-symbol. An e cient implementation of the noncoherent decision feedback detector is suggested which, for M-ary modulation and a Kuser channel, requires O(MK) computational complexity. Upper and lower (genie-aided) bounds on symbol error probability of the proposed detectors are obtained. It is shown that signi cant improvements over the post-decorrelative noncoherent detectors of [1] are possible. Su cient conditions are obtained which guarantee, without ignoring errorpropagation e ects, that the asymptotic (high SNR) performance of the generalized likelihood ratio test (GLRT) based decision feedback strategy can be as good as its genie-aided version in which past users' decisions are perfect.
Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology.

DIOPATHIC thrombocytopenic purpura (ITP, also I known as primary immune thrombocytopenic purpura) is a hematologic disorder for which appropriate diagnostic and treatment strategies are uncertain. In 1994, the American Society of Hematology (ASH) established a panel to produce explicitly developed practice guidelines for the diagnosis and management of ITP. “Explicitly developed,” evidencebased practice guidelines, which are being issued increasingly by medical specialty societies, combine a critical appraisal of scientific evidence with practice recommendations that state clearly to what extent the guidelines are based either on published scientific evidence or opinion (eg, clinical experience). I4 More details about the clinical practice guideline movement are provided elsewhere. ’. ’ This report begins with a brief summary of the panel’s recommendations, followed by a more detailed analysis of its methodology, the findings of the comprehensive literature review, and a full presentation of the recommendations. The report concludes with recommendations for future research. As explained later, the recommendations are based on the panel’s opinion, derived from a systematic scoring methodology. (Only recommendations receiving scores of 1 .O to 3.0 or 7.0 to 9.0, as defined later in the text, are cited in this summary.)
Circadian Rhythm and Response to an Acute Stressor of Urinary Corticosterone, Testosterone, and Creatinine in Adult Male Mice

Abstract In small laboratory species, steroid measures can be obtained more frequently and less invasively from urine than blood. Insofar as urinary levels reflect systemic levels, they could provide advantages particularly for measurement of glucocorticoids, whose blood levels react rapidly to handling and stress. In Experiment 1, urinary samples were collected from male mice every second hour over a 14:10 h light:dark cycle. Samples were analyzed via enzyme immunoassay for corticosterone, testosterone, and creatinine. Corticosterone had peak concentrations 1 h after light offset and a trough 1 h after light onset. Testosterone showed peak concentrations 5–7 h after light onset and lowest concentrations during the dark phase of the cycle. Creatinine showed some variation over the light-dark cycle, but steroid measures showed similar trends with and without adjustment for creatinine. In Experiment 2, mice were stressed via an injection at times close to the determined peak and trough levels of corticosterone. In urinary samples taken 90 min after injection, corticosterone was significantly higher in injected animals at both times relative to levels in control animals, but testosterone was unaffected by injection stress. In Experiment 3, serum and urine samples were collected from mice every sixth hour across the diurnal cycle. Corticosterone peaked in urine and serum immediately after light offset, and urinary measures predicted those in serum. These data indicate that urinary corticosterone reflects systemic levels in mice, document circadian variation in urinary testosterone, and indicate that circadian variation in creatinine is minimal, but potentially relevant in stressed animals.
TIM-3 Expression Characterizes Regulatory T Cells in Tumor Tissues and Is Associated with Lung Cancer Progression

Background T cell immunoglobulin-3 (TIM-3) has been established as a negative regulatory molecule and plays a critical role in immune tolerance. TIM-3 is upregulated in exhausted CD8+ T cells in both chronic infection and tumor. However, the nature of TIM-3+CD4+ T cells in the tumor microenvironment is unclear. This study is to characterize TIM-3 expressing lymphocytes within human lung cancer tissues and establish clinical significance of TIM-3 expression in lung cancer progression. Methodology A total of 51 human lung cancer tissue specimens were obtained from pathologically confirmed and newly diagnosed non-small cell lung cancer (NSCLC) patients. Leukocytes from tumor tissues, distal normal lung tissues, and peripheral blood mononuclear cells (PBMC) were analyzed for TIM-3 surface expression by flow cytometry. TIM-3 expression on tumor-infiltrating lymphocytes (TILs) was correlated with clinicopathological parameters. Conclusions TIM-3 is highly upregulated on both CD4+ and CD8+ TILs from human lung cancer tissues but negligibly expressed on T cells from patients' peripheral blood. Frequencies of IFN-γ+ cells were reduced in TIM-3+CD8+ TILs compared to TIM-3−CD8+ TILs. However, the level of TIM-3 expression on CD8+ TILs failed to associate with any clinical pathological parameter. Interestingly, we found that approximately 70% of TIM-3+CD4+ TILs expressed FOXP3 and about 60% of FOXP3+ TILs were TIM-3+. Importantly, TIM-3 expression on CD4+ T cells correlated with poor clinicopathological parameters of NSCLC such as nodal metastasis and advanced cancer stages. Our study reveals a new role of TIM-3 as an important immune regulator in the tumor microenvironment via its predominant expression in regulatory T cells.