Miracle-dz/UniFAR-FTUs huggingface dataset:
Prenatal Maternal Antibiotics Treatment Alters the Gut Microbiota and Immune Function of Post-Weaned Prepubescent Offspring

This study aimed to investigate the immediate and continual perturbation to the gut microbiota of offspring in the weeks post-weaning and how these may be modulated by treating pregnant C57BL/6J dams with antibiotics (ABX). We used a broad-spectrum antibiotic cocktail consisting of ampicillin 1 mg/mL, neomycin 1 mg/mL, and vancomycin 0.5 mg/mL, or vancomycin 0.5 mg/mL alone, administered ad-lib orally to dams via drinking water during gestation and stopped after delivery. We analyzed the gut microbiota of offspring, cytokine profiles in circulation, and the brain to determine if there was evidence of a gut-immune-brain connection. Computationally predicted metabolic pathways were calculated from 16s rRNA sequencing data. ABX treatment can negatively affect the gut microbiota, including reduced diversity, altered metabolic activity, and immune function. We show that the maternal ABX-treatment continues to alter the offspring’s gut microbiota diversity, composition, and metabolic pathways after weaning, with the most significant differences evident in 5-week-olds as opposed to 4-week-olds. Lower levels of chemokines and inflammatory cytokines, such as interleukin (IL)-1α and IL-2, are also seen in the periphery and brains of offspring, respectively. In conclusion, this study shows maternal antibiotic administration alters gut microbiome profiles in offspring, which undergoes a continuous transformation, from week to week, at an early age after weaning.
Assessing psychological resilience: translation and validation of the Chinese version of the resilience evaluation scale (RES)

ABSTRACT Background The Resilience Evaluation Scale (RES) is a novel and freely available measure of psychological resilience (factored into self-confidence and self-efficacy). To date, psychometric properties were evaluated in Dutch and American samples, but not yet in a Chinese sample. Objective We aimed to validate the RES in a Chinese sample by examining its factor structure, reliability, and construct validity. Methods The RES was translated into Chinese following a cross-cultural translation and adaptation procedure. Self-report questionnaires including the RES, exposure to potentially traumatic events (PTE's), the PTSD checklist for DSM-5 (PCL-5), and scales for conceptually related constructs of psychological resilience were then administered via an online survey. Results In total, 484 Chinese adults (females, 66.9%; age: 27.33 ± 6.86 years) participated. Parallel analysis results suggested a one-factor structure for the Chinese RES. The Chinese RES demonstrated good internal consistency (Cronbach's alpha = 0.88). Construct validity was demonstrated through significant associations with hypothesised related constructs and through a relation with lower levels of PTSD among the PTE-exposed subsample (n = 116) via the mediating role of avoidant coping strategies, i.e. behavioural disengagement and self-blame. Conclusion Our results suggest that the RES is a reliable and valid assessment of psychological resilience to use in Chinese, in addition to its Dutch and English versions. The RES could potentially be adopted to measure psychological resilience in cross-cultural contexts. HIGHLIGHTS Psychological resilience refers to self-perceived capacities contributing to a favourable outcome after potentially traumatic events. The RES is a brief and freely available assessment of psychological resilience. The Chinese RES shows good reliability and validity. The RES could potentially be used in both Western and Eastern cultural backgrounds.
International Journal of Electrical and Computer Engineering (IJECE)

Received Dec 19, 2021 Revised May 26, 2022 Accepted Jun 30, 2022 Shot boundary detection is the fundamental technique that plays an important role in a variety of video processing tasks such as summarization, retrieval, object tracking, and so on. This technique involves segmenting a video sequence into shots, each of which is a sequence of interrelated temporal frames. This paper introduces two methods, where the first is for detecting the cut shot boundary via employing visual hybrid features, while the second method is to compare between them. This enhances the effectiveness of the performance of detecting the shot by selecting the strongest features. The first method was performed by utilizing hybrid features, which included statistics histogram of hue-saturation-value color space and grey level co-occurrence matrix. The second method was performed by utilizing hybrid features that include discrete wavelet transform and grey level co-occurrence matrix. The frame size decreased. This process had the advantage of reducing the computation time. Also used local adaptive thresholds, which enhanced the method’s performance. The tested videos were obtained from the BBC archive, which included BBC Learning English and BBC News. Experimental results have indicated that the second method has achieved (97.618%) accuracy performance, which was higher than the first and other methods using evaluation metrics.
Implementation and characterization of flash‐based hardware security primitives for cryptographic key generation

Hardware security primitives, also known as physical unclonable functions (PUFs), perform innovative roles to extract the randomness unique to specific hardware. This paper proposes a novel hardware security primitive using a commercial off‐the‐shelf flash memory chip that is an intrinsic part of most commercial Internet of Things (IoT) devices. First, we define a hardware security source model to describe a hardware‐based fixed random bit generator for use in security applications, such as cryptographic key generation. Then, we propose a hardware security primitive with flash memory by exploiting the variability of tunneling electrons in the floating gate. In accordance with the requirements for robustness against the environment, timing variations, and random errors, we developed an adaptive extraction algorithm for the flash PUF. Experimental results show that the proposed flash PUF successfully generates a fixed random response, where the uniqueness is 49.1%, steadiness is 3.8%, uniformity is 50.2%, and min‐entropy per bit is 0.87. Thus, our approach can be applied to security applications with reliability and satisfy high‐entropy requirements, such as cryptographic key generation for IoT devices.
Turning gate synthesis errors into incoherent errors

Using error correcting codes and fault tolerant techniques, it is possible, at least in theory, to produce logical qubits with significantly lower error rates than the underlying physical qubits. Suppose, however, that the gates that act on these logical qubits are only approximation of the desired gate. This can arise, for example, in synthesizing a single qubit unitary from a set of Clifford and $T$ gates; for a generic such unitary, any finite sequence of gates only approximates the desired target. In this case, errors in the gate can add coherently so that, roughly, the error $\epsilon$ in the unitary of each gate must scale as $\epsilon \lesssim 1/N$, where $N$ is the number of gates. If, however, one has the option of synthesizing one of several unitaries near the desired target, and if an average of these options is closer to the target, we give some elementary bounds showing cases in which the errors can be made to add incoherently by averaging over random choices, so that, roughly, one needs $\epsilon \lesssim 1/\sqrt{N}$. We remark on one particular application to distilling magic states where this effect happens automatically in the usual circuits.
Astrometric test of the weak equivalence principle

Weak equivalence principle (WEP) is, for the first time, tested by astrometry on quasars in the sky measured in two wavelengths. Compared to previous WEP tests based on the Shapiro time delay of massless particles, this one has profound superiority that nearly 1 700 quasars with best measured positions commonly in the optical and radio bands are available. It ensures that, among the tests with photons, this one can give the most significantly robust bound on possible violation of WEP.
Implications of Captured Interstellar Objects for Panspermia and Extraterrestrial Life

We estimate the capture rate of interstellar objects by means of three-body gravitational interactions. We apply this model to the Sun–Jupiter system and the Alpha Centauri A&B binary system, and find that the radius of the largest captured object is a few tens of km and Earth-sized, respectively. We explore the implications of our model for the transfer of life by means of rocky material. The interstellar comets captured by the “fishing net” of the solar system can be potentially distinguished by their differing orbital trajectories and ratios of oxygen isotopes through high-resolution spectroscopy of water vapor in their tails.
Signature of a Newborn Black Hole from the Collapse of a Supra-massive Millisecond Magnetar

An X-ray plateau followed by a steep decay (“internal plateau”) has been observed in both long and short gamma-ray burst (GRBs), implying that a millisecond magnetar operates in some GRBs. The sharp decay at the end of the plateau, marking the abrupt cessation of the magnetar’s central engine, has been considered the collapse of a supra-massive magnetar into a black hole (BH) when it spins down. If this “internal plateau” is indeed evidence of a magnetar central engine, the natural expectation in some candidates would be a signature from the newborn BH. In this work, we find that GRB 070110 is a particular case which shows a small X-ray bump following its “internal plateau. ” We interpret the plateau as a spin-down supra-massive magnetar and the X-ray bump as fallback BH accretion. This indicates that a newborn BH is likely active in some GRBs. Therefore, GRB 070110-like events may provide further support to the magnetar central engine model and enable us to investigate the properties of the magnetar as well as the newborn BH.
Anomalous Brownian motion via linear Fokker-Planck equations

According to a traditional point of view Boltzmann entropy is intimately related to linear Fokker-Planck equations (Smoluchowski, Klein-Kramers, and Rayleigh equations) that describe a well-known nonequilibrium phenomenon: (normal) Brownian motion of a particle immersed in a thermal bath. Nevertheless, current researches have claimed that non-Boltzmann entropies (Tsallis and Renyi entropies, for instance) may give rise to anomalous Brownian motion through nonlinear Fokker-Planck equations. The novelty of the present article is to show that anomalous diffusion could be investigated within the framework of non-Markovian linear Fokker-Planck equations. So on the ground of this non-Markovian approach to Brownian motion, we find out anomalous diffusion characterized by the mean square displacement of a free particle and a harmonic oscillator in absence of inertial force as well as the mean square momentum of a free particle in presence of inertial force.
Reliability, Validity and Temporal Stability of the Serbian Version of the Boston Carpal Tunnel Questionnaire

Background and Objectives: The aim of this study was to validate the Serbian version of the Boston Carpal Tunnel Questionnaire (BCTQ) and to evaluate temporal stability for the purpose of its implementation in the evaluation of Serbian patients with carpal tunnel syndrome (CTS). Materials and Methods: For the validation of the Serbian version of the BCTQ (BCTQSR), we tested 69 individuals with diagnosed CTS that were referred for a conservative treatment at the Institute for Rehabilitation. Neurophysiological tests were used for the electrophysiological grading (EG) of CTS severity in the study sample. The final version of the BCTQSR was given to the tested participants from the study on two occasions: test and retest, with a five-day period between the two measurements. Results: The mean value for the symptom severity subscale (SSS) of the BCTQSR was 3.01 ± 0.94; for the functional status subscale (FSS) of the BCTQSR it was 2.85 ± 1.00. Cronbach’s α for the SSS was 0.91 and 0.93 for the FSS. The intraclass correlation coefficients (ICCs) concerning the test–retest were significant (p < 0.001) and were 0.949 for the SSS and 0.959 for the FSS. Those with a higher EG grade had higher values of the SSS and FSS but without a statistical significance (p = 0.103 and p = 0.053, respectively). The intercorrelation of the BCTQSR subscales (SSS and FSS) on the test was significant (p < 0.001) with a correlation coefficient equal to 0.777. Conclusion: The Serbian version of the BCTQ (BCTQSR) was successfully culturally adopted. The BCTQSR was a valid and reliable instrument for the measurement of symptom severity and functional status in adults with CTS. Therefore, it can be used in clinical practice for patients with CTS.
Analisis Perbandingan Akurasi Metode Fuzzy Tsukamoto dan Fuzzy Sugeno Dalam Prediksi Penentuan Harga Mobil Bekas

Mobil merupakan transportasi darat yang sangat membantu aktivitas manusia dalam melakukan kegiatan seharihari. Toyota Avanza 47% mendominasi pasar mobil bekas dibanding merek lainnya. Dalam transaksi jual beli mobil bekas, selisih harga yang berbeda sering memiliki nilai yang jauh berbeda. Logika fuzzy dapat digunakan untuk memprediksi harga mobil bekas dengan memperhatikan beberapa aspek. Penelitian ini bertujuan untuk membandingkan tingkat akurasi prediksi antara metode Fuzzy Tsukamoto dengan Fuzzy Sugeno. Fuzzy Tsukamoto bersifat intuitif dan dapat memberikan tanggapan berdasarkan informasi yang bersifat kualitatif, tidak akurat, dan ambigu. Sedangkan Fuzzy Sugeno yang terdiri atas basis aturan dengan beberapa aturan penarikan kesimpulan fuzzy. Gagasan ini ditulis dengan analisis melalui studi literatur buku, jurnal dan pengumpulan data berupa dataset maupun landasan teori yang terkait. Berdasarkan analisis data sampel penjualan mobil bekas dan pembandingan 2 metode dengan variabel yang sama. Hasil dari penelitian yang telah dihitung, diperoleh bahwa metode Fuzzy Tsukamoto memiliki tingkat error sebesar 8% dan Fuzzy Sugeno sebesar 38% pada prediksi harga mobil Toyota Avanza bekas.
Protective Effects of Topical Administration of Laminarin in Oxazolone-Induced Atopic Dermatitis-like Skin Lesions

Laminarin is a polysaccharide isolated from brown marine algae and has a wide range of bioactivities, including immunoregulatory and anti-inflammatory properties. However, the effects of laminarin on atopic dermatitis have not been demonstrated. This study investigated the potential effects of topical administration of laminarin using a Balb/c mouse model of oxazolone-induced atopic dermatitis-like skin lesions. Our results showed that topical administration of laminarin to the ear of the mice improved the severity of the dermatitis, including swelling. Histological analysis revealed that topical laminarin significantly decreased the thickening of the epidermis and dermis and the infiltration of mast cells in the skin lesion. Serum immunoglobulin E levels were also significantly decreased by topical laminarin. Additionally, topical laminarin significantly suppressed protein levels of oxazolone-induced proinflammatory cytokines, such as interleukin-1β, tumor necrosis factor-α, monocyte chemoattractant protein-1, and macrophage inflammatory protein-1α in the skin lesion. These results indicate that topical administration of laminarin can alleviate oxazolone-induced atopic dermatitis by inhibiting hyperproduction of IgE, mast cell infiltration, and expressions of proinflammatory cytokines. Based on these findings, we propose that laminarin can be a useful candidate for the treatment of atopic dermatitis.
Analysis of scattered protons in deuteron electrodisintegration with a polarized electron beam and an internal polarized target

Nuclear strl. ~cture and the underlyi~lg internucleon (NN) interaction are central to the understanding of how nucleons interact. However, despite decades of research, Quantum Chromodynamics, which governs the interactions of quarks making up nucleons, continues to evade a fully tractable solution. As a result, understanding of the nucleon and how it interacts with other nucleons is not complete. Due to its simple composition, the deuteron has long been important in understanding the structure of the NN potential. In particular, the tensor asymmetry, AT, a-nd beam-vector asymmetry, A z , from deuteron electrodisintegrat,ion, 21? (~, e 1 N ) N 1 , asre sensitive to the existence of a tensor component in the NN interaction. The Bates Large Acceptance Spectrometer Toroid (BLAST) provides a unique opportunity to measure deuteron electrodisintegration asymmetries at low momentum transfer. BLAST combines a high-duty polarized electron beam, an Atomic Beam Sollrce (ABS) target of highly-polarized deuterium atoms, and a large-acceptance spectrometer detector. This work reports on measurements of '4: and A: for Q2 ranges between 0.1 and 0.5 ( G ~ V / C ) ~ . Comparisons with Monte Carlo simulations based on the current understanding of the deuteron are made, and conclusions are drawn. Thesis Supervisor: Robert P. Redwine Title: Professor, Dean for Undergraduate Education
Development of an Epoxy-Based Rapid Tool with Low Vulcanization Energy Consumption Channels for Liquid Silicone Rubber Injection Molding

Liquid silicone rubber (LSR) parts have some distinct characteristics such as superior heat stability, low-temperature flexibility, aging resistance, and chemical resistance. From an industrial standpoint, the uniform vulcanization temperature of LSR is an important research point. However, the uniformity of the vulcanization temperature of LSR has been limited since the layout of the cartridge heater incorporated in the conventional steel mold does not follow the profile of the mold cavity. Metal additive manufacturing can be used to make LSR injection molds with conformal heating channels and conformal cooling channels simultaneously. However, this method is not suitable for a mold required to develop a new LSR product. In this study, a cost-effective approach was proposed to manufacture an LSR injection mold for the pilot run of a new optical lens. A rapid tool with low vulcanization energy consumption channels was proposed, which was incorporated with both a conformal heating channel (CHC) and conformal cooling channel (CCC) simultaneously. The function of the CHC was to vulcanize the LSR in the cavity uniformly, resulting in a shorter cycle time. The function of the CCC was to keep the LSR in a liquid state for reducing runner waste. It was found that the equation of y = −0.006x3 + 1.2114x2 − 83.221x + 1998.2 with the correlation coefficient of 0.9883 seemed to be an optimum trend equation for predicting the solidification time of a convex lens (y) using the vulcanizing hot water temperature (x). Additionally, the equation of y = −0.002x3 + 0.1329x2 − 1.0857x + 25.4 with the correlation coefficient of 0.9997 seemed to be an optimum prediction equation for the solidification time of a convex lens (y) using the LSR weight (x) since it had the highest correlation coefficient. The solidification time of a convex lens could be reduced by about 28% when a vulcanizing hot water temperature of 70 °C was used in the LSR injection mold with CHC.
Clinical Outcomes of 3D-Printed Bioresorbable Scaffolds for Bone Tissue Engineering—A Pilot Study on 126 Patients for Burrhole Covers in Subdural Hematoma

Burrhole craniostomy is commonly performed for subdural hematoma (SDH) evacuation, but residual scalp depressions are often cosmetically suboptimal for patients. OsteoplugTM, a bioresorbable polycaprolactone burrhole cover, was introduced by the National University Hospital, Singapore, in 2006 to cover these defects, allowing osseous integration and vascular ingrowth. However, the cosmetic and safety outcomes of OsteoplugTM-C—the latest (2017) iteration, with a chamfered hole for subdural drains—remain unexplored. Data were collected from a single institution from April 2017 to March 2021. Patient-reported aesthetic outcomes (Aesthetic Numeric Analog (ANA)) and quality of life (EQ-5D-3L including Visual Analog Scale (VAS)) were assessed via telephone interviews. Clinical outcomes included SDH recurrence, postoperative infections, and drain complications. OsteoplugTM-C patients had significantly higher satisfaction and quality of life compared to those without a burrhole cover (ANA: 9 [7, 9] vs. 7 [5, 8], p = 0.019; VAS: 85 [75, 90] vs. 70 [50, 80], p = 0.021), and the absence of a burrhole cover was associated with poorer aesthetic outcomes after multivariable adjustment (adjusted OR: 4.55, 95% CI: 1.09–22.68, p = 0.047). No significant differences in other clinical outcomes were observed between OsteoplugTM-C, OsteoplugTM, or no burrhole cover. Our pilot study supports OsteoplugTM-C and its material polycaprolactone as suitable adjuncts to burrhole craniostomy, improving cosmetic outcomes while achieving comparable safety outcomes.
Self-Healing Hydrogels: Development, Biomedical Applications, and Challenges

Polymeric hydrogels have drawn considerable attention as a biomedical material for their unique mechanical and chemical properties, which are very similar to natural tissues. Among the conventional hydrogel materials, self-healing hydrogels (SHH) are showing their promise in biomedical applications in tissue engineering, wound healing, and drug delivery. Additionally, their responses can be controlled via external stimuli (e.g., pH, temperature, pressure, or radiation). Identifying a suitable combination of viscous and elastic materials, lipophilicity and biocompatibility are crucial challenges in the development of SHH. Furthermore, the trade-off relation between the healing performance and the mechanical toughness also limits their real-time applications. Additionally, short-term and long-term effects of many SHH in the in vivo model are yet to be reported. This review will discuss the mechanism of various SHH, their recent advancements, and their challenges in tissue engineering, wound healing, and drug delivery.
The Evolution of Lyman-alpha Absorbers in the Redshift Range 0.5 < z < 1.9

We investigate the evolution and the statistical properties of the Ly α absorbers of the intergalactic medium (IGM) in the largely unexplored redshift range z = 0.5−1.9. We use high-resolution (R ≥ 30 000) UV (STIS) and optical (VLT/UVES and Keck/HIRES) spectra of nine bright quasars with zem 10 13.64 cm −2 ) thin out faster (γ = 1.50 ± 0.45). The break in their evolution predicted for z = 1.5−1.7 cannot be seen down to z = 0.7. On the other hand, a comparison with values from the literature for the local number density gives a hint that this break occurs at lower redshift. 2. The distribution of the column densities of the absorbers is complete down to NHI = 10 12.90 cm −2 . It can be approximated by a single power law with the exponent β = 1.60 ± 0.03 over almost three orders of magnitude. β is redshift independent. 3. The Ly α lines with lower column densities as well as the higher column density lines show marginal clustering with a 2σ significance over short distances (∆ v< 200 km s −1 and ∆ v< 100 km s −1 , respectively). We do not see any difference in the clustering with either column density or redshift. 4. The distribution of the Doppler parameters has a mean value of b = (34± 22) km s −1 . This value is typical for the analyzed region.
Learning in the Limit: Income Inference from Credit Extension

Combining a randomized controlled trial with bank account and survey data, I show that credit-limit extensions significantly increase consumer expectations about their future income. A one-dollar increase in credit limit raises consumer income expectations over the next six months by 40 cents and total consumption by 34 cents. The expectation changes explain around 34% of the total spending responses to credit limit extensions. The results show that consumers infer information from lenders’ credit-supply decisions, and this learning behavior impacts consumers’ economic decision-making greatly.