Miracle-dz/UniFAR-FTUs huggingface dataset:
PERSONALITY AND THE PROVISION OF SUPPORT EMOTIONS FELT AND SIGNALED

After decades spent establishing a link between social support and well-being, re­ searchers have turned their attention to important related issues: determination of the processes through which support exerts its effects, and the prediction of support receipt. Our work (e.g., Collins, 1994; Trobst, Collins, & Embree, 1994) has addressed the latter question, but with the assumption that the two research agendas are related: Since they are part of the same process, factors that promote supportive behavior and the function that support serves should be linked in a meaningful way. By approaching the prediction of support from a process perspective, we have been able to formulate hypotheses that link specific attributes of providers and recipients to a specific support function. This may be critical to the development of support interventions (Thoits, 1985). Currently, the applied value of support research has been limited by what Heller, Price, and Hogg (1990) describe as "implicit assumptions of homogeneity concerning the support process, how it is delivered, and who benefits from its administration"
Sex Differences in Quality of Life in Patients With Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) predominantly affects women. Clinical phenotype and outcomes in SLE may vary by sex and are further complicated by unique concerns that are dependent upon sex‐defined roles. We aimed to describe sex differences in disease‐specific quality of life (QoL) assessment scores using the Lupus Patient‐Reported Outcome (LupusPRO) tool in a large international study.
The potential role of flaxseed oil on lead acetate-induced kidney injure in adult male albino rats

Lead (Pb +2 ) intoxication may initiate many disorders in humans and animals. This study investigated the role of flaxseed oil in protecting rats against Pb +2 exposures. The results showed that the administration of flaxseed oil efficiently protected albino rats against the Pb +2 caused injury, as revealed by some improvement in the histological structure of kidney as well as the restoration of the body weights loss of Pb +2 treated animals. At the same time, flaxseed oil decreased the levels of serum creatinine, blood urea nitrogen, uric acid, lipid peroxidation and nitric oxide production with concomitant elevation in glutathione, catalase, superoxide dismutase, glutathione reductase, glutathione-S-transferase and glutathione peroxidase activities. Thus, this study suggests the possibility of flaxseed oil usefulness in limiting toxicant induced by environmental heavy metals.
BIOACTIVE COMPOUNDS IN ORGANIC APPLE JUICES ENRICHE D WITH CHOKEBERRY AND GREEN TEA EXTRACT Summary

„Journal of Research and Applications in Agricultural Engineering” 2017, Vol. 62(4) Katarzyna ŚWIĄDER, Ewelina HALLMANN 173 Dominika ŚREDNICKA-TOBER, Renata KAZIMIERCZAK, Ewa REMBIAŁKOW SKA, Tomasz STROK, Katarzyna ŚWIĄDER, Ewelina HALLMANN Warsaw University of Life Sciences (WULS-SGGW), Fac ulty of Human Nutrition and Consumer Sciences, Department of Functional Food, Ecological Food and Commodities ul. Nowoursynowska 159C, 02-776 Warszawa, Poland e-mail: dominika_srednicka_tober@sggw.pl
RecSys Challenge 2014: an ensemble of binary classifiers and matrix factorization

In this paper we give our solution to the RecSys Challenge 2014. In our ensemble we use (1) a mix of binary classification methods for predicting nonzero engagement, including logistic regression and SVM; (2) regression methods for directly predicting the engagement, including linear regression and gradient boosted trees; (3) matrix factorization and factorization machines over the user-movie matrix, by using user and movie features as side information. For most of the methods, we use the GraphLab Create implementation. Our current nDCG@10 achieves 0.874. We release our experiments as IPython Notebooks.
Ocular outcomes in 4-year old prematurely born children.

Purpose The aim of the study was to assess functional and structural ophthalmologic outcomes in 4-year old very low birth weight children (VLBW). Material and Methods A group of 82 VLBW children including: (1) children without retinopathy of prematurity – group O (n = 30), (2) children with retinopathy of prematurity with no indications for laser coagulation- group 1 (n = 20 ), (3) children with retinopathy of prematurity treated with laser coagulation – group 2 (n = 32) were enrolled. Functional (visual acuity, visual evoked potentials, stereopsis, color vision test) and structural (anterior eye segment examination and fundoscopy) outcome, cycloplegic refraction, intraocular pressure and angle of squint were examined in all children. Developmental Test of Visual Perception was also assessed. Results Very good visual acuity was presented in 56 (68.3%) patients, good visual acuity in 11 (13.4%) children, visual acuity between 0.4 and 0.2 in 13 (15.9%) and unfavorable function (equal or less than 0.1) was observed in 2 (2.4%) children. Twenty-three patients (28.1%) were myopic, 57 patients (69.5%) were hyperopic. Astigmatism > 1D occurred in 49 (59.8%) patients. Anisometropia larger than 2 D occurred in 7 patients (8.7%). There was no statistical difference between frequency of mentioned above complications between the groups. Abnormal VEP results were more common (14 children -54%) in group 2 as compared to other groups (group 0 - 7 children -25%, group 1 – 4 children -24%; p = 0.044). Moreover, the lower percentage of group 2 children presented stereopsis vision (46.9%, group 0 – 93.3%, group 1 – 90%; p<0.05). Children with retinopathy of prematurity treated with laser coagulation had significantly lower Developmental Test of Visual Perceptions scores. In group 1, in 1 child naevus pigmentosus of the eyelid was observed, in group 2 in one child eyeball atrophy in the right eye and aphakia in the left eye were diagnosed. In 1 child in group 0 optic disc drusen were observed, in 2 children optic discs were pale. In 2 children in group 2 retinal detachment stage 5 was diagnosed. Conclusion An important factor affecting final ophthalomolgical assessment in prematurely born children is retinopathy of prematurity treated with laser coagulaion. Children with retinopathy of prematurity without laser coagulation had examinations results comparable wih children without retinopathy of prematurity. Diode laser photocoagulation is an effective method of treatment fot active stages of retinopathy of prematurity.
Arterial aging: a journey into subclinical arterial disease

Purpose of reviewAge-associated arterial alterations in cells, matrix, and biomolecules are the foundation for the initiation and progression of cardiovascular diseases in older persons. This review focuses on the latest advances on the intertwining of aging and disease within the arterial wall at the cell and molecular levels. Recent findingsEndothelial dysfunction, vascular smooth muscle cell (VSMC) proliferation/invasion/secretion, matrix fragmentation, collagenization and glycation are characteristics of an age-associated arterial phenotype that creates a microenvironment enriched with reactive oxygen species (ROS) for the pathogenesis of arterial disease. This niche creates an age-associated arterial secretory phenotype (AAASP), which is orchestrated by the concerted effects of numerous age-modified angiotensin II signaling molecules. Most of these biomolecular, cell, and matrix modifications that constitute the AAASP can be elicited by experimental hypertension or atherosclerosis at a younger age. The arterial AAASP also shares features of a senescence-associated secretory phenotype (SASP) identified in other mesenchymocytes, that is, fibroblasts. SummaryA subclinical AAASP evolves during aging. Targeting this subclinical AAASP may reduce the incidence and progression of the quintessential age-associated arterial diseases, that is, hypertension and atherosclerosis.
When silence is not golden: Engaging adolescents and young adults in discussions around end‐of‐life care choices

Managing end-of-life care (EoL) is always emotionally taxing. Honest discussions about prognosis and EoL decision-making are often delayed due to questions about the legal competence of adolescents and young adults (AYA) to make decisions for themselves [1], providers feeling unprepared or without adequate skills to guide EoL discussions, or parental concern that discussing plans, including life support options or presenting an EoL planning document may send the message that the medical team wishes to withdraw care or that death is imminent. Data suggest that allowing AYA involvement in EoL planning can help parents and healthcare providers make informed decisions, alleviate distress, avoid decisional regret, and perhaps improve the patient’s quality of life (QoL) by respecting their values, beliefs, and preferences [2–4]. This commentary addresses recent progress in the field and focuses on how healthcare professionals can approach advance care planning (ACP) with AYA, involve their family members, and engage the entire health care team.
Myocardial delayed enhancement in pulmonary hypertension: pulmonary hemodynamics, right ventricular function, and remodeling.

OBJECTIVE The purpose of this study was to assess predictors of MRI-identified septal delayed enhancement mass at the right ventricular (RV) insertion sites in relation to RV remodeling, altered regional mechanics, and pulmonary hemodynamics in patients with suspected pulmonary hypertension (PH). SUBJECTS AND METHODS Thirty-eight patients with suspected PH were evaluated with right heart catheterization and cardiac MRI. Ten age- and sex-matched healthy volunteers acted as controls for MRI comparison. Septal delayed enhancement mass was quantified at the RV insertions. Systolic septal eccentricity index, global RV function, and remodeling indexes were quantified with cine images. Peak systolic circumferential and longitudinal strain at the sites corresponding to delayed enhancement were measured with conventional tagging and fast strain-encoded MRI acquisition, respectively. RESULTS PH was diagnosed in 32 patients. Delayed enhancement was found in 31 of 32 patients with PH and in one of six patients in whom PH was suspected but proved absent (p = 0.001). No delayed enhancement was found in controls. Delayed enhancement mass correlated with pulmonary hemodynamics, reduced RV function, increased RV remodeling indexes, and reduced eccentricity index. Multiple linear regression analysis showed RV mass index was an independent predictor of total delayed enhancement mass (p = 0.017). Regional analysis showed delayed enhancement mass was associated with reduced longitudinal strain at the basal anterior septal insertion (r = 0.6, p < 0.01). Regression analysis showed that basal longitudinal strain remained an independent predictor of delayed enhancement mass at the basal anterior septal insertion (p = 0.02). CONCLUSION In PH, total delayed enhancement burden at the RV septal insertions is predicted by RV remodeling in response to increased afterload. Local fibrosis mass at the anterior septal insertion is associated with reduced regional longitudinal contractility at the base.
Effects of in situ CO 2 enrichment on structural characteristics, photosynthesis, and growth of the Mediterranean seagrass Posidonia oceanica

Abstract. Seagrass is expected to benefit from increased carbon availability under future ocean acidification. This hypothesis has been little tested by in situ manipulation. To test for ocean acidification effects on seagrass meadows under controlled CO2/pH conditions, we used a Free Ocean Carbon Dioxide Enrichment (FOCE) system which allows for the manipulation of pH as continuous offset from ambient. It was deployed in a Posidonia oceanica meadow at 11 m depth in the Northwestern Mediterranean Sea. It consisted of two benthic enclosures, an experimental and a control unit both 1.7 m3, and an additional reference plot in the ambient environment (2 m2) to account for structural artifacts. The meadow was monitored from April to November 2014. The pH of the experimental enclosure was lowered by 0.26 pH units for the second half of the 8-month study. The greatest magnitude of change in P. oceanica leaf biometrics, photosynthesis, and leaf growth accompanied seasonal changes recorded in the environment and values were similar between the two enclosures. Leaf thickness may change in response to lower pH but this requires further testing. Results are congruent with other short-term and natural studies that have investigated the response of P. oceanica over a wide range of pH. They suggest any benefit from ocean acidification, over the next century (at a pH of ∼ 7.7 on the total scale), on Posidonia physiology and growth may be minimal and difficult to detect without increased replication or longer experimental duration. The limited stimulation, which did not surpass any enclosure or seasonal effect, casts doubts on speculations that elevated CO2 would confer resistance to thermal stress and increase the buffering capacity of meadows.
Proteomic Profiling Exosomes from Vascular Smooth Muscle Cell

Vascular smooth muscle cells (VSMC) and endothelial cells (EC) communicate mutually to coordinate vascular development and homeostasis. Exosomes are emerging as one type of the mediators involved in this communication. Characterizing proteins in the exosomes is the critical first step in understanding how the VSMC‐EC crosstalk is mediated by exosomes.
The BLOS1‐Interacting Protein KXD1 is Involved in the Biogenesis of Lysosome‐Related Organelles

Biogenesis of lysosome‐related organelles (LROs) complex‐1 (BLOC‐1) is an eight‐subunit complex involved in lysosomal trafficking. Interacting proteins of these subunits expand the understanding of its biological functions. With the implementation of the naïve Bayesian analysis, we found that a human uncharacterized 20 kDa coiled‐coil KxDL protein, KXD1, is a BLOS1‐interacting protein. In vitro binding assays confirmed the interaction between BLOS1 and KXD1. The mouse KXD1 homolog was widely expressed and absent in Kxd1 knockout (KO) mice. BLOS1 was apparently reduced in Kxd1‐KO mice. Mild defects in the melanosomes of the retinal pigment epithelia and in the platelet dense granules of the Kxd1‐KO mouse were observed, mimicking a mouse model of mild Hermansky–Pudlak syndrome that affects the biogenesis of LROs.
Thinking critically about and researching algorithms

ABSTRACT More and more aspects of our everyday lives are being mediated, augmented, produced and regulated by software-enabled technologies. Software is fundamentally composed of algorithms: sets of defined steps structured to process instructions/data to produce an output. This paper synthesises and extends emerging critical thinking about algorithms and considers how best to research them in practice. Four main arguments are developed. First, there is a pressing need to focus critical and empirical attention on algorithms and the work that they do given their increasing importance in shaping social and economic life. Second, algorithms can be conceived in a number of ways – technically, computationally, mathematically, politically, culturally, economically, contextually, materially, philosophically, ethically – but are best understood as being contingent, ontogenetic and performative in nature, and embedded in wider socio-technical assemblages. Third, there are three main challenges that hinder research about algorithms (gaining access to their formulation; they are heterogeneous and embedded in wider systems; their work unfolds contextually and contingently), which require practical and epistemological attention. Fourth, the constitution and work of algorithms can be empirically studied in a number of ways, each of which has strengths and weaknesses that need to be systematically evaluated. Six methodological approaches designed to produce insights into the nature and work of algorithms are critically appraised. It is contended that these methods are best used in combination in order to help overcome epistemological and practical challenges.
DJ‐1, PINK1, and their effects on mitochondrial pathways

Genetic forms of parkinsonism are interesting for two particular reasons. First, finding a gene identifies a cause for a disease that would otherwise be unexplained. Second, finding several genes for the same disorder allows us to reconstruct molecular pathways that, in the example of Parkinson's disease, are be associated with the survival of dopamine neurons in the substantia nigra. Two rare causes of parkinsonism, DJ‐1 and PINK1, are associated with mitochondria. This organelle has long been linked with Parkinson's disease, and recent results are starting to show how mutations impact mitochondrial function. In this short review, I will discuss how we can use some of this information to understand why it is that neurons become dysfunctional in PD. © 2010 Movement Disorder Society
A statistical approach for resolving problematical word boundaries in Chinese lexicography

Word segmentation is an important topic in Chinese language processing. Although state-of-the-art segmentation algorithms demonstrate that more than 90% accuracy could possibly be achieved, there remains the subtle question of what constitutes a Chinese word. In this paper, we focus on two-character word strings which often raise doubts even for lexicographers as to whether the two characters should be segmented or kept as one word. We experiment with the feasibility of modelling human judgement on such problematical word boundaries by corpus-based mutual information. Preliminary results show that the strength of correlation between the two measures might be lexically as well as structurally dependent, and mutual information only partially models human judgement on problematic Chinese word boundaries.
Construire une pratique réflexive : comprendre et agir

"Former des praticiens reflexifs, oui. mais comment? Dans les deux premieres parties, l'auteur s'attache a donner des reperes pour comprendre ce « nouveau paradigme » de formation. La proposition de concepts innovants telle que celui d'approche multireflechie ouvre ainsi de nouvelles perspectives de recherche et de conception des formations. Cette etude theorique aboutit a la proposition d'un cadre general de conception de dispositifs de developpement de la pratique reflexive. L'ouvrage se termine par la presentation d'un dispositif inedit de formation qui illustre l'operationnalisation de ce cadre : ARPPEGE. Deux groupes de participants y sont suivis dans leur developpement professionnel a travers l'etude des effets et limites de la formation proposee. A travers de nombreuses illustrations et une mise en forme attractive, l'auteur nous propose de poursuivre deux objectifs : comprendre ce qu'est la pratique reflexive et agir pour son developpement en formation. " (Tire du doc.)
Getting acquainted with their landscape: research by design as a tool to understand people's perception of current and future landscapes

In the current policy setting in Western European society, spatial planning tends to emphasise the achievement of policy intentions through the realisation of actual spatial interventions and the growing importance of citizens as spatial actors. The place-based planning approach refers to the fact that the design of integrated interventions must be tailored to places, since it largely depends on the knowledge and preference of people living in it.This paper unpacks the planning practice in Flanders by analysing and describing two landscape cases, as the actual arenas where different social activities compete, many key-actors are gathered and spatial planning processes and interventions take place. The key concepts “governance”, landscape quality” and “research by design” are defined. We investigate if research by design can be used as a tool to explore people's perception of current and future landscapes.The case studies disclose a deliberative process, which makes use of a research by design methodology, is not only able to gain knowledge on people's perception of current and future landscapes but can also improve the mutual understanding of the appreciation of landscapes by various spatial actors.Both cases illustrate the current struggle of authorities with the growing importance and knowledge of citizens and the difficulties the policy makers experience introducing these actors and knowledge in planning processes. The designs and masterplan developed within the cases refer to the place-based approach, as it is proposed by the European authorities.
In Silico Modelling of Treatment-Induced Tumour Cell Kill: Developments and Advances

Mathematical and stochastic computer (in silico) models of tumour growth and treatment response of the past and current eras are presented, outlining the aims of the models, model methodology, the key parameters used to describe the tumour system, and treatment modality applied, as well as reported outcomes from simulations. Fractionated radiotherapy, chemotherapy, and combined therapies are reviewed, providing a comprehensive overview of the modelling literature for current modellers and radiobiologists to ignite the interest of other computational scientists and health professionals of the ever evolving and clinically relevant field of tumour modelling.
Noninvasive, in vivo imaging of subcortical mouse brain regions with 1.7  μm optical coherence tomography.

A spectral/Fourier domain optical coherence tomography (OCT) intravital microscope using a supercontinuum light source at 1.7 μm was developed to study subcortical structures noninvasively in the living mouse brain. The benefits of 1.7 μm for deep tissue brain imaging are demonstrated by quantitatively comparing OCT signal attenuation characteristics of cortical tissue across visible and near-infrared wavelengths. Imaging of hippocampal tissue architecture and white matter microvasculature are demonstrated in vivo through thinned-skull, glass coverslip-reinforced cranial windows in mice. Applications of this novel platform include monitoring disease progression and pathophysiology in rodent models of Alzheimer's disease and subcortical dementias, including vascular dementia.
Improving molecular cancer class discovery through sparse non-negative matrix factorization

MOTIVATION Identifying different cancer classes or subclasses with similar morphological appearances presents a challenging problem and has important implication in cancer diagnosis and treatment. Clustering based on gene-expression data has been shown to be a powerful method in cancer class discovery. Non-negative matrix factorization is one such method and was shown to be advantageous over other clustering techniques, such as hierarchical clustering or self-organizing maps. In this paper, we investigate the benefit of explicitly enforcing sparseness in the factorization process. RESULTS We report an improved unsupervised method for cancer classification by the use of gene-expression profile via sparse non-negative matrix factorization. We demonstrate the improvement by direct comparison with classic non-negative matrix factorization on the three well-studied datasets. In addition, we illustrate how to identify a small subset of co-expressed genes that may be directly involved in cancer.