Miracle-dz/UniFAR-FTUs huggingface dataset:
Haemodynamics of the pressor effect of oral water in human sympathetic denervation due to autonomic failure.

Oral water ingestion increases blood pressure in normal elderly subjects and in patients suffering from autonomic failure, but the time course of the haemodynamic changes is not known. We therefore studied 14 subjects with documented sympathetic denervation due to pure autonomic failure, with continuous haemodynamic recordings obtained before and after ingestion of 500 ml of distilled water at room temperature. The time course of changes in values of systolic and diastolic beat-by-beat finger blood pressure, heart rate, stroke volume, cardiac output, ejection fraction and total peripheral resistance were analysed. Systolic blood pressure rose from 115+/-8 mmHg (mean+/-S.E.M.) to 133+/-8 mmHg (P<0.001), and diastolic blood pressure from 64+/-4 to 73+/-4 mmHg (P<0.001), with the pressor response beginning a few minutes after water ingestion, plateauing between 10 and 35 min (peak at 14 min), and returning to baseline at 50 min. Heart rate fell from 71+/-2.5 to 67+/-2 beats/min (P<0.001), and total peripheral resistance increased from 1.31+/-0.19 to 1.61+/-0.24 m-units (P<0.001). There were no significant changes in ejection fraction, stroke volume or cardiac output. This study confirmed a pressor response to oral water in subjects with sympathetic denervation. The temporal profile of the response did not favour reflexly mediated sympathetic activation. As subjects with autonomic failure are prone to salt and water depletion, and since blood pressure is exquisitely sensitive to such changes, it may be that the observed response is due to repletion or restoration of intravascular and extravascular fluid volume.
Rapid Assessment with Qualitative Telephone Interviews: Lessons from an Evaluation of California’s Healthy Families Program & Medi-Cal for Children

California’s Healthy Families/Medi-Cal for Children (HF/MCC) program provides low- and no-cost health insurance to low-income children. In December 1999 and January 2000, 72 community-based organizations (CBOs) were contracted by California’s Department of Health Services (DHS) to supply culturally appropriate HF/MCC outreach and enrollment services. This article describes the incorporation of a qualitative telephone interview component for rapid assessment purposes after the planned quantitative analysis of program records faltered in 2001 due to missing, invalid, and unreliable data. We describe the rapid interview protocol and discuss benefits and barriers. The protocol can serve as a model for others interested in using rapid qualitative telephone interviews within their own evaluation efforts.
Landmark-oriented visual navigation of a mobile robot

The authors describe a method of landmark based vehicle guidance used for navigation in corridors and similar indoor environments. Motion tasks are specified by a symbolic course description without providing explicit geometric information. A video sensor system is used for environmental perception and landmark detection. Aspects of sensor data processing and vehicle guidance are discussed. Experimental results are reported. <<ETX>>
Weakly Secure Network Coding

In this work we consider the problem of secure data transmission on an acyclic multicast network. A new information theoretic model for security is proposed that defines the system as secure if an eavesdropper is unable to get any “meaningful” information about the source. The “wiretap” network model by Cai and Yeung in which no information of the source is made available to the eavesdropper is a special case in the new model. We consider the case when the number of independent messages available to the eavesdropper is less than the multicast capacity of the network. We show that under the new security requirements communication is possible at the multicast capacity. A linear transformation is provided for networks with a given linear code to make the system secure. The transformation needs to be done only at the source and the operations at the intermediate nodes remain unchanged. We also show that if random coding scheme is used the probability of the system being secure can be made arbitrarily close to one by coding over a large enough field.
The Effect of Skew on the Magnitude of Product-Moment Correlations

Abstract The effect of transforming actual skewed variables toward symmetry on the intercorrelations among the transformed variables was examined. The results showed that average correlations increased in all 20 cases studied, even though the transformations to correct skew produced slightly greater nonlinear relationships in some cases. Because the F and t tests for the significance of r are directly proportional to the size of r, correcting skew increases power and at the same time better meets underlying assumptions of those tests. The implications of the findings as well as potential difficulties associated with correction of skew in correlational research are discussed.
Alternative Strategies in the UK Agro-Food System: Interrogating the Alterity of Farmers' Markets

In recent years we have witnessed the development of numerous alternative strategies (AS) within the UK agro-food system intent on overcoming, or at least circumventing, some of the problems associated with the globalisation of food production and consumption. Within these AS, there is an intention to reconnect food to the social, cultural and environmental context of its production, leading to considerable interest in their potential to engender sustained change within the food system. However, it is apparent that AS are likely to face various pressures on their underlying integrity and alterity, and their possible re-incorporation within mainstream processes. There is a need, therefore, to interrogate the durability of AS, which this paper does through its critical examination of farmers' markets (FMs). Drawing upon a number of FM cases studies, it examines the engagement of producers and consumers, both with each other, but also with the exchange context of FMs. The resultant data are assessed within the conceptual domains of embeddedness and regard as a means of better understanding the nature of FMs as an AS. The paper concludes by outlining the implications of this research for our comprehension of AS more broadly.
Therapeutic Efficacy of CEP-33779, a Novel Selective JAK2 Inhibitor, in a Mouse Model of Colitis-Induced Colorectal Cancer

Constitutively activated STAT3 and STAT5 are expressed in a wide variety of human malignancies including solid and hematopoietic cancers and often correlate with a poor prognosis and resistance to multiple therapies. Given the well established role of STAT3 in tumorigenesis, inhibition of Janus-activated kinase 2 (JAK2) activity might represent an attractive therapeutic approach. Using a mouse model of colitis-induced colorectal cancer, we show that a novel, orally active, selective JAK2 inhibitor, CEP-33779, induced regression of established colorectal tumors, reduced angiogenesis, and reduced proliferation of tumor cells. Histopathologic analysis confirmed reduced incidence of histologic-grade neoplasia by CEP-33779. Tumor regression correlated with inhibition of STAT3 and NF-κB (RelA/p65) activation in a CEP-33779 dose–dependent manner. In addition, the expression of proinflammatory, tumor-promoting cytokines interleukin (IL)-6 and IL-1β was strongly reduced upon JAK2 inhibition. The ability of CEP-33779 to suppress growth of colorectal tumors by inhibiting the IL-6/JAK2/STAT3 signaling suggests a potential therapeutic utility of JAK2 inhibitors in multiple tumors types, particularly those with a strong inflammatory component. Mol Cancer Ther; 11(4); 984–93. ©2012 AACR.
CXCR2: From Bench to Bedside

Leukocyte recruitment to sites of infection or tissue damage plays a crucial role for the innate immune response. Chemokine-dependent signaling in immune cells is a very important mechanism leading to integrin activation and leukocyte recruitment. CXC chemokine receptor 2 (CXCR2) is a prominent chemokine receptor on neutrophils. During the last years, several studies were performed investigating the role of CXCR2 in different diseases. Until now, many CXCR2 inhibitors are tested in animal models and clinical trials and promising results were obtained. This review gives an overview of the structure of CXCR2 and the signaling pathways that are activated following CXCR2 stimulation. We discuss in detail the role of this chemokine receptor in different disease models including acute lung injury, COPD, sepsis, and ischemia-reperfusion-injury. Furthermore, this review summarizes the results of clinical trials which used CXCR2 inhibitors.
Legitimacy in the multilevel European polity

To be at the same time effective and liberal, governments must normally be able to count on voluntary compliance – which, in turn, depends on the support of socially shared legitimacy beliefs. In Western constitutional democracies, such beliefs are derived from the distinct, but coexistent traditions of ‘republican’ and ‘liberal’ political philosophy. Judged by these criteria, the European Union – when considered by itself – appears as a thoroughly liberal polity which, however, lacks all republican credentials. But this view (which seems to structure the debates about the ‘European democratic deficit’) ignores the multilevel nature of the European polity, where the compliance of citizens is requested, and needs to be legitimated, by member states, whereas the Union appears as a ‘government of governments’, which is entirely dependent on the voluntary compliance of its member states. What matters primarily, therefore, is the compliance–legitimacy relationship between the Union and its member states – which, however, is normatively constrained by the basic compliance–legitimacy relationship between member governments and their constituents. Given the high consensus requirements of European legislation, member governments could, and should, be able to assume political responsibility for European policies in which they had a voice, and to justify them in ‘communicative discourses’ in the national public space. That is not necessarily so for ‘non-political’ policy choices imposed by the European Court of Justice (ECJ). By enforcing its ‘liberal’ programme of liberalization and deregulation, the ECJ may presently be undermining the ‘republican’ bases of member-state legitimacy. Where that is the case, open non-compliance is a present danger, and political controls of judicial legislation may be called for.
Improvement in Risk Factors for Metabolic Syndrome and Insulin Resistance in Overweight Youth Who Are Treated With Lifestyle Intervention

OBJECTIVE. To evaluate the prevalence of risk factors that are associated with the metabolic syndrome and insulin resistance in overweight youth and to determine the effect of a short-term, family-centered, lifestyle intervention on various associated anthropometric and metabolic measures. METHODS. Overweight youth who were between 8 and 16 years of age participated in a 12-week, family-centered, lifestyle intervention program. Anthropometric and metabolic measures were assessed before the program in all participants (n = 109) and after the program in a subset of the participants (n = 43). RESULTS. At baseline, 49.5% of youth had multiple risk factors associated with the metabolic syndrome, based on a modified definition of the National Cholesterol Education Program, and 10% had impaired fasting glucose and/or impaired glucose tolerance. Measures of insulin resistance correlated significantly with the risk factors of the metabolic syndrome. Forty-three youth had pre- and postintervention evaluations that showed statistically significant improvements in body mass index, systolic blood pressure, lipids (total, low-density lipoprotein cholesterol, and triglycerides), postprandial glucose, and leptin levels. CONCLUSION. Overweight youth have multiple risk factors associated with the metabolic syndrome. A 12-week lifestyle program may have a positive effect on reducing risk factors for the metabolic syndrome and insulin resistance in overweight youth.
Chlorophyll Biosynthesis Gene Evolution Indicates Photosystem Gene Duplication, Not Photosystem Merger, at the Origin of Oxygenic Photosynthesis

An open question regarding the evolution of photosynthesis is how cyanobacteria came to possess the two reaction center (RC) types, Type I reaction center (RCI) and Type II reaction center (RCII). The two main competing theories in the foreground of current thinking on this issue are that either 1) RCI and RCII are related via lineage divergence among anoxygenic photosynthetic bacteria and became merged in cyanobacteria via an event of large-scale lateral gene transfer (also called "fusion" theories) or 2) the two RC types are related via gene duplication in an ancestral, anoxygenic but protocyanobacterial phototroph that possessed both RC types before making the transition to using water as an electron donor. To distinguish between these possibilities, we studied the evolution of the core (bacterio)chlorophyll biosynthetic pathway from protoporphyrin IX (Proto IX) up to (bacterio)chlorophyllide a. The results show no dichotomy of chlorophyll biosynthesis genes into RCI- and RCII-specific chlorophyll biosynthetic clades, thereby excluding models of fusion at the origin of cyanobacteria and supporting the selective-loss hypothesis. By considering the cofactor demands of the pathway and the source genes from which several steps in chlorophyll biosynthesis are derived, we infer that the cell that first synthesized chlorophyll was a cobalamin-dependent, heme-synthesizing, diazotrophic anaerobe.
Cardiac blood flow measurements in stable full term small for gestational age neonates.

BACKGROUND Cardiac blood flow measurements are useful in the haemodynamic management of neonates. Cardiac blood flows can be estimated with functional echocardiography as follows; flow in Superior Vena Cava (SVC), Right Ventricular Outflow (RVO) and Left Ventricular Outflow (LVO). Studies in preterm infants have shown that abnormal superior vena cava flow is associated with poor neurodevelopmental outcomes. To date, normative data on LVO, RVO and SVC flows has been established for term appropriate for gestational age neonates and preterm neonates, but no data is available on RVO, LVO and SVC flows for term small for gestational age neonates. OBJECTIVE To determine Right Ventricular Output (RVO), Left Ventricular Output (LVO) and Superior Vena Cava (SVC) flow after the transitional period in stable full term Small for Gestational Age (SGA) neonates. DESIGN Observational study. SETTING A tertiary care, perinatal centre in western Maharashtra, India. PARTICIPANTS Full term (37 to 41 weeks) small for gestational age (weight below 10th percentile for gestational age) infants who were born during the study period. METHODS RVO, LVO and SVC flows were measured by functional echocardiography on day 7 of life in stable full term SGA neonates from January 2011 to August 2011. Infants who required respiratory or cardiovascular support and intensive care unit admissions for any indication and those with a clinical suspicion of an infection within 48 hours after data collection were excluded from the study. STATISTICAL ANALYSES Unpaired t-test was used to compare SVC flow between symmetric and asymmetric SGA neonates. MAIN OUTCOME MEASURE Measurements of RVO, LVO and SVC in term SGA neonates on day 7 of life. RESULTS We performed measurements in 52 term SGA neonates with a median (range) birth weight of 2.190 (1.600-2.410) kg. Fifty two measurements were analyzed on day 7. The mean (SD) RVO, LVO and SVC flows were 255.59 (57.42) , 214.61 (52.04) and 126.28 (31.23) mL/kg/min. CONCLUSION This study provides RVO, LVO and SVC flow values in a cohort of stable term SGA neonates after the transitional period.
Mathematics of Isogeny Based Cryptography

These lectures notes were written for a summer school on Mathematics for post-quantum cryptography in Thi\`es, Senegal. They try to provide a guide for Masters' students to get through the vast literature on elliptic curves, without getting lost on their way to learning isogeny based cryptography. They are by no means a reference text on the theory of elliptic curves, nor on cryptography; students are encouraged to complement these notes with some of the books recommended in the bibliography. The presentation is divided in three parts, roughly corresponding to the three lectures given. In an effort to keep the reader interested, each part alternates between the fundamental theory of elliptic curves, and applications in cryptography. We often prefer to have the main ideas flow smoothly, rather than having a rigorous presentation as one would have in a more classical book. The reader will excuse us for the inaccuracies and the omissions.
Throwing the Baby Out with the Drinking Water: Unintended Consequences of Arsenic Mitigation Efforts in Bangladesh

The 1994 discovery of arsenic in groundwater in Bangladesh prompted a massive public health campaign that led 20% of the population to switch from backyard wells to less convenient drinking water sources that had a higher risk of fecal contamination. We find evidence of unintended health consequences by comparing mortality trends between households in the same village that did and did not have an incentive to abandon shallow tubewells. Post-campaign, households encouraged to switch water sources have 46% higher rates of child mortality than those not encouraged to switch. Switching away from arsenic-contaminated wells also increased adult mortality.
Effective and efficient AI-based approaches to cloud resource provisioning

This paper aims to design efficient and effective approaches to virtual network embedding (VNE) problem, which deals with the embedding of a requested virtual network (VN) in an underlying physical (substrate network) infrastructure. When the node and link constraints (including CPU, memory, network bandwidth, and network delay) are both taken into account, the VN embedding problem is NP-hard, even in the offline case. The capabilities of some Artificial Intelligence (AI) techniques have been validated in handling the VN problem. In this paper, we propose two efficient and effective VNE algorithms based on differential evolutionary (DE) technique. The extensive simulation results show that DE technique performs some orders of magnitude faster than GA and PSO-based VNE algorithms in achieving the comparable long-term revenue of Infrastructure providers.
Our Future Mind: Epochal Developments of Perinatal Clinical Psychology

This paper clarifies the meaning of Perinatal Clinical Psychology by removing the prejudice and the stereotypes that unfortunately pervade children health care facilities still nowadays. The author goes over the basic principles that neuroscience has recently demonstrated in the development of the brain from the fetus to the infant, the child and the adult. The brain is self-generating through experience and not on the basis of genome. Epygenetics accounts for it. The brain needs to learn so as to be able to develop. Nobody has a brain that is the same as anybody elseâ€™s and therefore nobody has a mind that is the same as anybody elseâ€™s. The brain generates the mind and, in turn, the mind regenerates the brain in a ceaseless feedback. The experience that generates and renews the brain continuously comes from interpersonal relationships. The greatest incidence of this kind of development comes from the relationships with the parents and the caregivers and depends on the emotional moment of the relationship. This opens up transgenerational perspectives. The quality of the mind (and the brain) of the parents and caregivers produces the quality of the mind of the children. The latter, in turn, become adults, condition the mind of their children in cascade effect from one generation to the following. This transmission can produce an improvement but also a worsening for the future generations. As a consequence, Perinatal Clinical Psychology becomes important for prevention and psychological support to the children and the families at risk.
Incentivized Peer-Assisted Streaming for On-Demand Services

As an efficient distribution mechanism, Peer-to-Peer (P2P) technology has become a tremendously attractive solution to offload servers in large-scale video streaming applications. However, in providing on-demand asynchronous streaming services, P2P streaming design faces two major challenges: how to schedule efficient video sharing between peers with asynchronous playback progresses? how to provide incentives for peers to contribute their resources to achieve a high level of system-wide Quality-of-Experience (QoE)? In this paper, we present iPASS, a novel mesh-based P2P VoD system, to address these challenges. Specifically, iPASS adopts a dynamic buffering-progress-based peering strategy to achieve high peer bandwidth utilization with low system maintenance cost. To provide incentives for peer uploading, iPASS employs a differentiated prefetching design that enables peers with higher contribution prefetch content at higher speed. A distributed adaptive taxation algorithm is developed to balance the system-wide QoE and service differentiations among heterogeneous peers. To assess the performance of iPASS, we built a detailed packet-level P2P VoD simulator and conducted extensive simulations. It was demonstrated that iPASS can completely offload server when the average peer upload bandwidth is more than 1.2 times the streaming rate. Furthermore, we showed that the distributed incentive algorithm motivates peers to contribute and collaboratively achieve a high level of system wide QoE.
A secure and effective biometric‐based user authentication scheme for wireless sensor networks using smart card and fuzzy extractor

User authentication is a prominent security requirement in wireless sensor networks (WSNs) for accessing the real‐time data from the sensors directly by a legitimate user (external party). Several user authentication schemes are proposed in the literature. However, most of them are either vulnerable to different known attacks or they are inefficient. Recently, Althobaiti et al. presented a biometric‐based user authentication scheme for WSNs. Although their scheme is efficient in computation, in this paper, we first show that their scheme has several security pitfalls such as (i) it is not resilient against node capture attack; (ii) it is insecure against impersonation attack; and (iii) it is insecure against man‐in‐the‐middle attack. We then aim to propose a novel biometric‐based user authentication scheme suitable for WSNs in order to withstand the security pitfalls found in Althobaiti et al. scheme. We show through the rigorous security analysis that our scheme is secure and satisfies the desirable security requirements. Furthermore, the simulation results for the formal security verification using the most widely used and accepted Automated Validation of Internet Security Protocols and Applications tool indicate that our scheme is secure. Our scheme is also efficient compared with existing related schemes. Copyright © 2015 John Wiley & Sons, Ltd.
Functional health literacy and the risk of hospital admission among Medicare managed care enrollees.

OBJECTIVES This study analyzed whether inadequate functional health literacy is an independent risk factor for hospital admission. METHODS We studied a prospective cohort of 3260 Medicare managed care enrollees. RESULTS Of the participants, 29.5% were hospitalized. The crude relative risk (RR) of hospitalization was higher for individuals with inadequate literacy (n = 800; RR = 1.43; 95% confidence interval [CI] = 1.24, 1.65) and marginal literacy (n = 366; RR = 1.33; 95% CI = 1.09, 1.61) than for those with adequate literacy (n = 2094). In multivariate analysis, the adjusted relative risk of hospital admission was 1.29 (95% CI = 1.07, 1.55) for individuals with inadequate literacy and 1.21 (95% CI = 0.97, 1.50) for those with marginal literacy. CONCLUSIONS Inadequate literacy was an independent risk factor for hospital admission among elderly managed care enrollees.