Miracle-dz/UniFAR-FTUs huggingface dataset:
Changing minds: Children's inferences about third party belief revision

Abstract By the age of 5, children explicitly represent that agents can have both true and false beliefs based on epistemic access to information (e.g., Wellman, Cross, & Watson, 2001). Children also begin to understand that agents can view identical evidence and draw different inferences from it (e.g., Carpendale & Chandler, 1996). However, much less is known about when, and under what conditions, children expect other agents to change their minds. Here, inspired by formal ideal observer models of learning, we investigate children's expectations of the dynamics that underlie third parties’ belief revision. We introduce an agent who has prior beliefs about the location of a population of toys and then observes evidence that, from an ideal observer perspective, either does, or does not justify revising those beliefs. We show that children's inferences on behalf of third parties are consistent with the ideal observer perspective, but not with a number of alternative possibilities, including that children expect other agents to be influenced only by their prior beliefs, only by the sampling process, or only by the observed data. Rather, children integrate all three factors in determining how and when agents will update their beliefs from evidence.
Treatment Outcomes of A Randomized Trial of Unruptured Brain Arteriovenous Malformation-Eligible Unruptured Brain Arteriovenous Malformation Patients

BACKGROUND The guideline for treating unruptured brain arteriovenous malformations (ubAVMs) remains controversial. A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA) reported lower risk of stroke or death with conservative management compared to interventional treatment. There were numerous limitations to the study, including short follow-up period and disproportionate number of patients treated with surgery and embolization. OBJECTIVE To evaluate whether treatment of ARUBA-eligible patients have acceptable outcomes at our institution. METHODS Retrospective analysis was performed on 673 patients with brain AVMs treated at our institution between 2001 and 2014. One hundred five patients were ARUBA eligible and included in the study. Patients were divided into the microsurgery or Gamma Knife Radiosurgery (GKS; Elekta, Stockholm, Sweden) arm depending on their final treatment. Mean follow-up period was 43 mo (range 4-136 mo). Primary outcome was stroke or death. RESULTS A total of 8 (7.6%) patients had a stroke or died. The overall risk of stroke or death was 11.4% (5 of 44 patients) for the microsurgery arm and 4.9% (3 of 61 patients) for the GKS arm. The annual rates of stroke or death were 2.1%, 4.0%, and 1.2% for the entire patient cohort, microsurgery arm, and GKS arm, respectively. AVM obliteration rates at the end of the follow-up period were 95.5% and 47.5% for the microsurgery and GKS arms, respectively. CONCLUSION We report a lower overall risk of stroke or death in our ARUBA-eligible patients following treatment than ARUBA. Our results suggest that microsurgery and GKS may be appropriate treatments for patients with ubAVM.
Combined sustained release of BMP2 and MMP10 accelerates bone formation and mineralization of calvaria critical size defect in mice

Abstract The effect of dual delivery of bone morphogenetic protein-2 (BMP-2) and matrix metalloproteinase 10 (MMP10) on bone regeneration was investigated in a murine model of calvarial critical-size defect, hypothesizing that it would result in an enhanced bone formation. Critical-size calvarial defects (4 mm diameter) were created in mice and PLGA microspheres preloaded with either BMP-2, MMP10 or a microsphere combination of both were transplanted into defect sites at different doses. Empty microspheres were used as the negative control. Encapsulation efficiency was assessed and in vivo release kinetics of BMP-2 and MMP10 were examined over 14 days. Histological analyses were used to analyze bone formation after four and eight weeks. Combination with MMP10 (30 ng) significantly enhanced BMP-2 (600 ng)-mediated osteogenesis, as confirmed by the increase in percentage of bone fill (p < .05) at four weeks. Moreover, it also increased mineral apposition rate (p < .05), measured by double labeling with tetracycline and calceine. MMP10 accelerates bone repair by enhancing BMP-2-promoted bone healing and improving the mineralization rate. In conclusion combination of MMP10 and BMP-2 may become a promising strategy for repair and regeneration of bone defects.
The Condition‐Dependent Development of Carotenoid‐Based and Structural Plumage in Nestling Blue Tits: Males and Females Differ

Despite the importance of proximate mechanisms for understanding costs and functions of signals, relatively little is known about physiological processes underlying colorful plumage production. We investigated yellow carotenoid‐based breast plumage and ultraviolet (UV)/blue structural color of tail feathers in nestling blue tits. At peak plumage production and at fledging, we examined plasma concentration of protein, the substance of feathers, and levels of carotenoids, which are deposited in yellow plumage and also required for support of growth and immune development. Males showed more UV‐shifted hue and higher chroma and UV chroma of the tail feathers. In males only, tail chroma and UV chroma were strongly but negatively related to circulating plasma protein at the period of peak feather production. Breast plumage was more chromatic in males, and yellow coloration was strongly condition dependent in males only. Production of more chromatic plumage appeared to deplete carotenoids from plasma, since male fledglings had less circulating carotenoids than females. This had no obvious consequences for these males, since coloration was unrelated to cell‐mediated immune responses, humoral immune status, stress, and parasitism. Nonetheless, the pronounced sex specificity of condition dependence of structural and carotenoid‐based coloration is suggestive of a signaling function of the fledgling plumage.
Behavioral and neural indices of affective coloring for neutral social stimuli

Emotional processing often continues beyond the presentation of emotionally evocative stimuli, which can result in affective biasing or coloring of subsequently encountered events. Here, we describe neural correlates of affective coloring and examine how individual differences in affective style impact the magnitude of affective coloring. We conducted functional magnetic resonance imaging in 117 adults who passively viewed negative, neutral, and positive pictures presented 2s prior to neutral faces. Brain responses to neutral faces were modulated by the valence of preceding pictures, with greater activation for faces following negative (vs. positive) pictures in the amygdala, dorsomedial and lateral prefrontal cortex, ventral visual cortices, posterior superior temporal sulcus, and angular gyrus. Three days after the MRI scan, participants rated their memory and liking of previously encountered neutral faces. Individuals higher in trait positive affect and emotional reappraisal rated faces as more likable when preceded by emotionally arousing (negative or positive) pictures. Additionally, greater amygdala responses to neutral faces preceded by positively valenced pictures were associated with greater memory for these faces three days later. Collectively, these results reveal individual differences in how emotions spill over onto the processing of unrelated social stimuli, resulting in persistent and affectively biased evaluations of such stimuli.
Wireless information and power transfer in two-way amplify-and-forward relaying channels

Various wireless networks have made the ambient radio frequency signals around the world. Wireless information and power transfer (WIPT) enables the devices to recycle energy from these ambient radio frequency signals and process information simultaneously. In this paper, we develop a WIPT protocol in two-way amplify-and-forward relaying channels, where two sources exchange information via an energy harvesting relay node. The relay node collects energy from the received signal and uses it as the transmission power to forward the received signal. We analytically derive the exact expressions of the outage probability, the ergodic capacity and the finite-SNR diversity-multiplexing trade-off (DMT). Furthermore, the tight closed-form upper and lower bounds of the outage probability and the ergodic capacity are then developed. Moreover, the impact of the power splitting ratio is also evaluated and analyzed. Finally, we show that compared to the non-cooperative relaying scheme, the proposed protocol is a green solution to offer higher transmission rate and more reliable communication without consuming additional resource.
Automated Management of Exercise Intervention at the Point of Care: Application of a Web-Based Leg Training System

Background Recent advances in information and communication technology have prompted development of Web-based health tools to promote physical activity, the key component of cardiac rehabilitation and chronic disease management. Mobile apps can facilitate behavioral changes and help in exercise monitoring, although actual training usually takes place away from the point of care in specialized gyms or outdoors. Daily participation in conventional physical activities is expensive, time consuming, and mostly relies on self-management abilities of patients who are typically aged, overweight, and unfit. Facilitation of sustained exercise training at the point of care might improve patient engagement in cardiac rehabilitation. Objective In this study we aimed to test the feasibility of execution and automatic monitoring of several exercise regimens on-site using a Web-enabled leg training system. Methods The MedExercise leg rehabilitation machine was equipped with wireless temperature sensors in order to monitor its usage by the rise of temperature in the resistance unit (Δt°). Personal electronic devices such as laptop computers were fitted with wireless gateways and relevant software was installed to monitor the usage of training machines. Cloud-based software allowed monitoring of participant training over the Internet. Seven healthy participants applied the system at various locations with training protocols typically used in cardiac rehabilitation. The heart rates were measured by fingertip pulse oximeters. Results Exercising in home chairs, in bed, and under an office desk was made feasible and resulted in an intensity-dependent increase of participants’ heart rates and Δt° in training machine temperatures. Participants self-controlled their activities on smart devices, while a supervisor monitored them over the Internet. Individual Δt° reached during 30 minutes of moderate-intensity continuous training averaged 7.8°C (SD 1.6). These Δt° were used as personalized daily doses of exercise with automatic email alerts sent upon achieving them. During 1-week training at home, automatic notifications were received on 4.4 days (SD 1.8). Although the high intensity interval training regimen was feasible on-site, it was difficult for self- and remote management. Opportunistic leg exercise under the desk, while working with a computer, and training in bed while viewing television were less intensive than dosed exercise bouts, but allowed prolonged leg mobilization of 73.7 minutes/day (SD 29.7). Conclusions This study demonstrated the feasibility of self-control exercise training on-site, which was accompanied by online monitoring, electronic recording, personalization of exercise doses, and automatic reporting of adherence. The results suggest that this technology and its applications are useful for the delivery of Web-based exercise rehabilitation and cardiac training programs at the point of care.
A Model for Detecting and Locating Behaviour Changes in Mobile Touch Targeting Sequences

Touch offset models capture users' targeting behaviour patterns across the screen. We present and evaluate the first extension of these models to explicitly address behaviour changes. We focus on user changes in particular: Given only a series of touch/target locations (x, y), our model detects 1) if the user has changed therein, and if so, 2) at which touch. We evaluate our model on smartphone targeting and typing data from the lab (N=28) and field (N=30). The results show that our model can exploit touch targeting sequences to reveal user changes. Our model outperforms existing non-sequence touch offset models and does not require training data. We discuss the model's limitations and ideas for further improvement. We conclude with recommendations for its integration into future touch biometric systems.
A high neutrophil to lymphocyte ratio prior to BRAF inhibitor treatment is a predictor of poor progression-free survival in patients with metastatic melanoma

BackgroundSome studies have shown that a high neutrophil/lymphocyte ratio (NLR) ≥4 before initiating ipilimumab treatment is an independent prognostic indicator of poor survival in patients with metastatic melanoma (MM). ObjectivesTo determine whether the NLR before starting BRAF inhibitor (BRAFi) treatment in patients with (MM) is associated with progression-free survival (PFS). Materials & methodsThis retrospective study included 49 patients consecutively receiving BRAFi for MM between July 2012 and December 2014. Cox proportional hazards regression was used to analyse the relationship between NLR and other factors, such as lactate dehydrogenase (LDH), performance status, BRAFi as firstor second-line therapy, and corticosteroid intake with PFS. The NLR before starting BRAFi was significantly associated with PFS based on univariate analysis and multivariate analysis adjusted for potential confounding factors, such as LDH activity, ulceration, performance status, first-line therapy, and corticosteroid intake. A high NLR (continuous variable) was associated with short PFS (HR: 1.35; 95% CI: 1.07-1.70; p = 0.01), and NLR ≥4 was associated with shorter PFS (HR: 3.24; 95% CI: 1.30-8.12; p = 0.01). Corticosteroid intake was not associated with short PFS based on multivariate analysis.ConclusionAn NLR > 4, before starting BRAFi treatment, is an independent prognostic indicator of poor progression-free survival.
System-Call Based Problem Diagnosis for PVFS

Abstract : We present a syscall-based approach to automatically diagnose performance problems, server-to-client propagated errors, and server crash/hang problems in PVFS. Our approach compares the statistical and semantic attributes of syscalls across PVFS servers in order to diagnose the culprit server, under these problems, for different file-system benchmarks-dd, PostMark and IOzone-in a PVFS cluster.
A new control method based on droop and Thevenin theorem to improve responses of VSIs in islanded MG

In this article, a new control method based on ordinary droop and Thevenin impedance from DG inverter-side in islanded microgrids is presented and the results have been discussed and compared to each other for both situations. In spite of improvements in steady state responses and rather desirable convergence in parameters such as circulating current among inverters, active and reactive powers, and the proportion of active power generated by inverters, ordinary droop provides inappropriate and long transient responses which is not favorable. In the novel method, the Thevenin impedance from inverter-side is utilized in one of the equations of droop leading up to significant improvement in transient responses of introduced parameters, both in their amplitude and response length time. Diagrams plotted for each of them, indicates these improvements.
Comparison of pulsed dye laser versus combined pulsed dye laser and Nd:YAG laser in the treatment of inflammatory acne vulgaris

ABSTRACT Background: Both pulsed dye laser and combined 585/1064-nm (sequential dual-wavelength PDL and Nd:YAG) laser improves inflammatory skin disorders including acne vulgaris. Objective: To compare the efficacy of 585-nm pulsed dye laser versus sequential dual-wavelength PDL and Nd:YAG in treatment of acne vulgaris. Patients and method: Thirty patients with acne vulgaris were treated by PDL alone on half of the face while contra lateral half was treated by combined 585/1064 nm laser. Results: The study showed that inflammatory acne lesions count was significantly reduced by 82.5% (p 0.0001) on PDL sides and by 83.5% (p 0.00001) on combined 585/1064-nm side after 8 weeks, while reduction of non-inflammatory acne lesions was observed at 8 weeks by 58.4% and 71.5% respectively. However, difference between the two modalities was not statistically significant. Conclusion: PDL and combined PDL/Nd:YAG laser treatment were found to be an effective, safe and well-tolerated treatment option for inflammatory and non-inflammatory acne vulgaris.
How can zygotes segregate entire parental genomes into distinct blastomeres? The zygote metaphase revisited

Zygote cytokinesis produces two symmetric blastomeres, which contain one copy of each parental genome. Contrary to this dogma, we recently discovered that mammalian zygotes can spontaneously segregate entire parental genomes into different blastomeres and coined this novel form of genome segregation heterogoneic division. The molecular mechanisms underlying the emergence of blastomeres with different parental genomes during the first mitotic cycle remain to be elucidated. Here, we speculate on which parental genome asymmetries could provide a mechanistic foundation for these remarkable zygote divisions. In reviewing the field and considering our findings, we revisit the architecture of the first zygotic metaphase by invoking asymmetric interactions between the mitotic spindle and the parental kinetochores. We also speculate on how asynchronous parental cell cycles can be a source of heterogoneic zygote divisions through the formation of parental genome private spindles.
Diagnostic and Prognostic Value of JC Virus DNA in Plasma in Progressive Multifocal Leukoencephalopathy

Background Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease caused by the polyomavirus JC (John Cunningham; JCV) that affects patients with impaired immune systems. While JCV-DNA detection in cerebrospinal fluid (CSF) is diagnostic of PML, the clinical significance of plasma JCV-DNA is uncertain. Methods We retrospectively analyzed plasma samples from PML patients that were drawn close to disease onset and from controls without PML. In PML patients, we compared plasma JCV-DNA detection and levels to clinical and laboratory parameters, and patient survival. Results JCV-DNA was detected in plasma of 49/103 (48%) patients with PML (20/24, 83%, human immunodeficiency virus [HIV] negative; 29/79, 37%, HIV-positive) and of 4/144 (3%) controls without PML (0/95 HIV-negative; 4/49, 8%, HIV-positive), yielding a diagnostic sensitivity and specificity of 48% and 97% (83% and 100% in HIV-negative; 37% and 92% in HIV-positive), respectively. Among 16 PML patients with undetectable CSF JCV-DNA, 4 (25%) had detectable plasma JCV-DNA. Plasma JCV-DNA levels were independently associated with CSF levels (P < .0001) and previous corticosteroid treatment (P = .012). Higher plasma JCV-DNA levels were associated with disease progression in HIV-negative patients (P = .005); in HIV-positive patients, there was an increased risk of progression only in those treated with combination antiretroviral therapy (cART; P < .0001). Conclusions Testing JCV-DNA in plasma might complement PML diagnosis, especially when CSF is unavailable or JCV-DNA not detectable in CSF. In addition, JCV-DNA plasma levels could be useful as a marker of disease progression in both HIV-negative and cART-treated, HIV-positive PML patients.
Using a multi criteria decision making model for managing computational resources at mobile ad-hoc cloud computing environment

Mobile devices have become one important part of our life. These devices has changed our life style by delivering various applications. These applications impacted our life and they are becoming more advanced, day by day. New applications requires more computation compared to a few years ago. By these definitions, mobile cloud computing (MCC) is evolved to help these devices known as resource poor devices. MCC helped to offload mobile devices computations to nearby cloud service provider in order to provide a high quality services to mobile users. Cyber foraging is state of art that uses MCC fundamentals to create a local cloud for local devices for computation offloading using other devices. In this article we will define criteria's needed to consider for choosing nodes suitable for computation offloading, using a multi criteria decision making algorithm known as Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS). Through simulation we will compare the results with different scenarios and compare TOPSIS results in such environment.
Sliding-Mode Observer Based Voltage-Sensorless Model Predictive Power Control of PWM Rectifier Under Unbalanced Grid Conditions

A sliding-mode grid voltage observer (SMGVO) is proposed and experimentally verified in this paper for voltage-sensorless operation under an unbalanced network. The fundamental positive sequence component (FPSC) and fundamental negative sequence component (FNSC) are inherently separated in the observer without employing any additional filters. Due to embedded filtering effect, high frequency chattering and harmonic ripples can be well suppressed. Additionally, dc components can be completely rejected. As a result, dc offset would not cause fundamental frequency oscillations in magnitude and frequency of the estimated FPSC and FNSC. Owing to the predictive ability of SMGVO, one-step delay can be directly compensated using state variables in the observer. By combining estimation and prediction into one stage, the designed SMGVO turns out to be a compact solution for finite-control-set model predictive power control without voltage sensors. Theoretical proof is derived to verify that FPSC and FNSC can be accurately estimated and separated. Experimental results obtained from a two-level PWM rectifier confirm the effectiveness of the whole control system.
Bus-Clamping-Based Direct Torque Control Strategy Dedicated to B6-Inverter Fed Symmetrical Two-Phase IM Drive

The paper deals with a novel DTC strategy dedicated to B6-inverter fed two-phase induction motor (2PIM) drives. It considers a bus-clamping-based approach in the synthesis of the vector selection table, leading to the “bus-clamping DTC” (BC-DTC). The study is initiated by a presentation of the B6-inverter fed 2PIM drive and a recall of the DTC background. Then, a special attention is paid to the design of the BC-DTC vector selection tables. For the sake of comparison, a conventional DTC strategy, inspired from the Takahashi one, is also considered. A simulation-based comparison of selected steady-state features is carried out. Then, a validation of the simulation results allied to an extension of the investigation is experimentally treated. The comparison is achieved by an investigation of the drive dynamic behavior under step- and ramp-shaped reversals of the reference speed. It is shown that the BC-DTC enables reductions of the switching frequency and of the torque ripple.