Miracle-dz/UniFAR-FTUs huggingface dataset:
THE POSSIBILITY OF OVERCOMING SEASONALITY OF POLISH COASTAL TOURISM – THE CASE OF THE POMORSKIE VOIVODSHIP

Purpose – In the Baltic Sea basin a particularly serious barrier to the development of coastal tourism is its seasonality. Its consequence is a lack of opportunities for sustainable development, which leads to imbalance in terms of local economy, the environment and social inequalities and tensions. The objective of this paper is to present the possible methods of overcoming negative effects of seasonality in the Polish coastal regions, especially in the Pomorskie Voivodship. Methodology – The study used a number of analytical methods based on sources obtained through desk research: the critical analysis of materials from the subject’s literature, statistical reports and an analysis of official documents, normative acts and regional strategies. The empirical part, presented in the form of a case study, was developed on the basis of results of expert interviews, including IDI representative of the regional tourist organization. Findings – Infrastructure used by the coastal tourism sector and the previous offer and practice of coastal tourism on the Polish coast have created mass tourism with neutral price elasticity of demand. Such a character of demand eliminates the effectiveness of some marketing tools. Contribution – Critical analysis of documents from the EU to the local levels of governance of coastal tourism has shown that there is a gap in this linkage of documents. There are not any strategies or plans at the national level dedicated to coastal tourism. This means that the framework of activity set at the supranational level is not effectively used by Poland. Local solutions without national government support may not generate the expected results.
The In Vivo Effect of Ytterbium-Doped Fiber Laser on Rat Buccal Mucosa as a Simulation of Its Effect on the Urinary Tract: A Preclinical Histopathological Evaluation

Purpose The aim of this study was to perform a histological analysis of the effect of a ytterbium-doped fiber (YDF) laser on oral buccal mucosa tissue in vivo to simulate its effect on the mucosa of the lower urinary tract. Methods A total of 90 8-week-old Sprague-Dawley rats were anesthetized with urethrane (1.2 g/kg intraperitoneally). A prespecified inner buccal mucosal site was irradiated with a YDF master-oscillator power amplifier (MOPA) system for 60 seconds, with output power settings of 0.5, 1, and 2 W, respectively, in 3 treatment groups. Specimens of irradiated tissue were harvested at 2 hours, 24 hours, 2 weeks, and 4 weeks after irradiation. The tissue specimens were stained with hematoxylin and eosin for histological analysis. Results In the group treated with 0.5 W, basal cell elongation and vacuolization were observed at 2 hours and 24 hours after treatment, respectively. No evident injury was observed after 2 or 4 weeks. The group treated with 1 W presented partial basal layer separation, and even complete epidermal ablation, within 2 hours. At 24 hours after laser treatment, new capillaries on an edematous background of fibroblasts and myofibroblasts, as well as profuse infiltration of the neutrophils to the basal layer, were observed. Collagen deposition and reepithelization were observed in specimens taken 2 weeks and 4 weeks after treatment. The group treated with 2 W presented bigger and deeper injuries at 2 hours after irradiation. Meanwhile, subepidermal bullae with full-thickness epidermal necrosis and underlying inflammatory infiltrate were observed 24 hours after treatment. The presence of fibrous connective tissue and collagen deposition were observed 2 weeks and 4 weeks after the treatment. Conclusions To our knowledge, this is the first report regarding the effect of a YDF laser on living tissue. Our study demonstrated that the typical histological findings of the tissue reaction to the YDF MOPA apparatus were very similar to those associated with thermal injuries. The extent and degree of tissue damage increased proportionally to the output power.
Delivering the potential of diagrammatic logics

Diagrammatic notations and reasoning have become a prominent focus of research over the last two decades. We have now reached a point where the techniques required to formalize diagrammatic logics and prove meta-level results, such as soundness and completeness, are well understood. Moreover, we have insight into what makes effective diagrams. However, the majority of progress has been on diagrammatic logics that are very limited in expressiveness. Whilst such logics are exemplars of the current state-of-the-art and are useful in simple cases, they remain somewhat far from realising the full potential of diagrammatic logics in the real world. In this talk, I will present a new diagrammatic logic, called concept diagrams, that has the level of expressiveness required to be applicable in industrial settings. In addition, I will describe how a more unified approach to diagrams research is necessary in order to fulfil the huge potential of diagrammatic notations. In particular, I will talk about the need for software tools to support the creation and use of diagrammatic logics, without which real-world take-up will be limited. Significant research is still necessary to deliver a unified approach and to achieve the vision for realising the full potential of diagrams.
Microinjection of Antibodies Targeting the Lamin A/C Histone-Binding Site Blocks Mitotic Entry and Reveals Separate Chromatin Interactions with HP1, CenpB and PML

Lamins form a scaffold lining the nucleus that binds chromatin and contributes to spatial genome organization; however, due to the many other functions of lamins, studies knocking out or altering the lamin polymer cannot clearly distinguish between direct and indirect effects. To overcome this obstacle, we specifically targeted the mapped histone-binding site of A/C lamins by microinjecting antibodies specific to this region predicting that this would make the genome more mobile. No increase in chromatin mobility was observed; however, interestingly, injected cells failed to go through mitosis, while control antibody-injected cells did. This effect was not due to crosslinking of the lamin polymer, as Fab fragments also blocked mitosis. The lack of genome mobility suggested other lamin-chromatin interactions. To determine what these might be, mini-lamin A constructs were expressed with or without the histone-binding site that assembled into independent intranuclear structures. HP1, CenpB and PML proteins accumulated at these structures for both constructs, indicating that other sites supporting chromatin interactions exist on lamin A. Together, these results indicate that lamin A-chromatin interactions are highly redundant and more diverse than generally acknowledged and highlight the importance of trying to experimentally separate their individual functions.
X‐linked Charcot‐Marie‐Tooth disease

The X‐linked form of Charcot‐Marie‐Tooth disease (CMT1X) is the second most common form of hereditary motor and sensory neuropathy. The clinical phenotype is characterized by progressive muscle atrophy and weakness, areflexia, and variable sensory abnormalities; central nervous system manifestations occur, too. Affected males have moderate to severe symptoms, whereas heterozygous females are usually less affected. Neurophysiology shows intermediate slowing of conduction and distal axonal loss. Nerve biopsies show more prominent axonal degeneration than de/remyelination. More than 400 different mutations in GJB1, the gene that encodes the gap junction (GJ) protein connexin32 (Cx32), cause CMT1X. Many Cx32 mutants fail to form functional GJs, or form GJs with abnormal biophysical properties. Schwann cells and oligodendrocytes express Cx32, and the GJs formed by Cx32 play an important role in the homeostasis of myelinated axons. Animal models of CMT1X demonstrate that loss of Cx32 in myelinating Schwann cells causes a demyelinating neuropathy. An effective therapy remains to be developed.
Elbrus-8C: The Latest Yield from MCST and MIPT Collaboration

This paper is dedicated to the traditional active participation of alumni and graduates of the MIPT state university in the design of computers and microprocessors of Elbrus series from Soviet supercomputers Elbrus-2 to the most recent models -- the dual-core heterogeneous Elbrus-2C+ processor and the 8-core Elbrus-8C processor.
On Communication Over Unknown Sparse Frequency-Selective Block-Fading Channels

This paper considers the problem of reliable communication over discrete-time channels whose impulse responses have length L and exactly S ≤ L non-zero coefficients, and whose support and coefficients remain fixed over blocks of N >; L channel uses but change independently from block to block. Here, it is assumed that the channel's support and coefficient realizations are both unknown, although their statistics are known. Assuming Gaussian non-zero-coefficients and noise, and focusing on the high-SNR regime, it is first shown that the ergodic noncoherent channel capacity has pre-log factor 1-(S)/(N) for any L. It is then shown that, to communicate with arbitrarily small error probability at rates in accordance with the capacity pre-log factor, it suffices to use pilot-aided orthogonal frequency-division multiplexing (OFDM) with S pilots per fading block, in conjunction with an appropriate noncoherent decoder. Since the achievability result is proven using a noncoherent decoder whose complexity grows exponentially in the number of fading blocks K, a simpler decoder, based on S+1 pilots, is also proposed. Its ε-achievable rate is shown to have pre-log factor equal to 1-(S+1)/(N) with the previously considered channel, while its achievable rate is shown to have pre-log factor 1-(S+1)/(N) when the support of the block-fading channel remains fixed over time.
Age‐dependent changes in skeletal muscle mass and visceral fat area in Japanese adults from 40 to 79 years‐of‐age

The age‐dependent loss of skeletal muscle mass is highly concerning in diverse aging populations. However, age‐dependent changes in muscle mass and the visceral fat area have not been well documented in Asian populations. The aim of the present study was to evaluate the age‐dependent changes in skeletal muscle mass and the visceral fat area in Japanese adults from 40 to 79 years‐of‐age.
Physical Activity, Aerobic Capacity, and Total Antioxidant Capacity in Healthy Men and in Men with Coronary Heart Disease

Objective. The purpose of the study was to assess total antioxidant capacity (TAC) of blood serum in relation with habitual leisure time physical activity (LTPA) and aerobic capacity in a group of 90 men with coronary heart disease (CHD) aged 34.8–77.0 years and in 90 age-matched peers without CHD. Methods. Two spectrophotometric methods were applied to assess TAC: Ferric Reducing Ability of Serum (TAC-FRAS) and 2.2-diphenyl-1-picryl-hydrazyl (TAC-DPPH) tests. Aerobic capacity was expressed as physical working capacity at 85% of the maximal heart rate (PWC85%HRmax). Results. CHD patients had higher values of TACFRAS (1.37 ± 0.28 versus 1.27 ± 0.23 mmol FeCl2·L−1; P < 0.05) but there were no group differences for TAC-DPPH and for uric acid (UA). Negative correlation was found between LTPA (also when calculated per kg of body mass) and TAC-DPPH in CHD patients. In CHD patients, TAC-FRAS and UA were lower in subjects with higher aerobic capacity expressed as PWC85%HRmax/kg. Those associations were not found in healthy men. Conclusions. We conclude that TAC of blood serum is moderately adversely related to LTPA and aerobic capacity in patients with CHD. UA, as the main determinant of serum TAC, may be partially responsible for those associations.
The Relationship between Post-Traumatic Stress Disorder Due to Brain Injury and Glutamate Intake: A Systematic Review

There is a growing body of evidence that suggests a connection between traumatic brain injury (TBI) and subsequent post-traumatic stress disorder (PTSD). While the exact mechanism is unknown, we hypothesize that chronic glutamate neurotoxicity may play a role. The consumption of dietary glutamate is a modifiable factor influencing glutamate levels in the blood and, therefore, in the brain. In this systematic review, we explored the relationship between dietary glutamate and the development of post-TBI PTSD. Of the 1748 articles identified, 44 met the inclusion criteria for analysis in this review. We observed that individuals from countries with diets traditionally high in glutamate had greater odds of developing PTSD after TBI (odds ratio = 15.2, 95% confidence interval 11.69 to 19.76, p < 0.01). These findings may support the hypothesis that chronically elevated blood glutamate concentrations caused by high dietary intake invoke neurodegeneration processes that could ultimately result in PTSD. Further studies will clarify whether lowering glutamate via diet would be an effective strategy in preventing or treating post-TBI PTSD.
Clasificador no supervisado para series de tiempo

A time series is a sequence of numerical data describing natural and/or artificial phenomena, therefore its analysis is of great interest in various areas of knowledge, being very useful in industrial, social and scientific development. An alternative for the analysis of time series is presented in classification techniques that allow the creation of groups of similar characteristics, however, there is a lot of phenomena in real life that do not have a prior or established classification, therefore supervised classifiers cannot be applied in such problems. This is why unsupervised classification approach arises, which allow us creating groups from a given set of data without any prior knowledge. In this work a methodology is proposed that allows the unsupervised classification of a set of time series using an unsupervised approach. This method consists of two stages: first, it was designed twelve different search techniques to find representative time series and second, an
Comparative Review of the Current and Future Strategies to Evaluate Bone Marrow Infiltration at Diffuse Large B-Cell Lymphoma Diagnosis

Diffuse large B-cell lymphoma (DLBCL) requires a complete staging at diagnosis that may have prognostic and therapeutic implications. The role of bone marrow (BM) biopsy (BMB) is controversial in the era of nuclear imaging techniques. We performed a comparative review of 25 studies focused on BM evaluation at DLBCL diagnosis, including at least two of the following techniques: BMB, flow cytometry, and positron emission tomography (PET-FDG). The report about BM involvement (BMi), diagnostic accuracy, and prognostic significance was collected and compared among techniques. A concordance analysis between BMB, FCM, and PET was also performed, and we deeply evaluated the implications of the different types of BMi: concordant by LBCL or discordant by low-grade B-cell lymphoma for both BMB and FCM, and focal or diffuse uptake pattern for PET. As a main conclusion, BMB, FCM, and PET are complementary tools that provide different and clinically relevant information in the assessment of BMi in newly diagnosed DLBCL.
A lattice of information

A framework is given for describing information and information flow. The authors show that information can be represented as a lattice. They motivate the idea that this framework is applicable for demonstrating security properties of systems. In particular, they show the relationship between the lattice representing information and the unwinding theorem. They also demonstrate the relationship between properties of this lattice and the aggregation problem. <<ETX>>
Generating Coordinated Natural Language and 3D Animations for Complex Spatial Explanations

Dynamically providing students with clear explanations of complex spatial concepts is critical for a broad range of knowledge-based educational and training systems. This calls for a realtime solution that can dynamically create 3D animated explanations that artfully integrate well-chosen speech with rich visualizations. Unfortunately, planning the integrated creation of 3D animation and spatial linguistic utterances in realtime requires coordinating the visual presentation of 3D objects and generating appropriate spatial phrases that accurately reflect the relative position, orientation, and direction of the objects presented. We present a visuo-linguistic framework for generating multimedia spatial explanations combining 3D animation and speech that complement one another. Because 3D animation planners require spatial knowledge in a geometric form and natural language generators require spatial knowledge in a linguistic form, a realtime multimedia planner interposed between the visual and linguistic components can serve as a mediator. This framework has been implemented in CINESPEAK, a multimedia explanation generator consisting of a visuo-linguistic mediator, a 3D animation planner, and a realtime natural language generator with a speech synthesizer. CINESPEAK has been used in conjunction with a prototype 3D learning environment in the domain of physics to generate realtime multimedia explanations of three dimensional electromagnetic fields, forces, and electrical current.
A grammar of Momu, a language of Papua New Guinea

This thesis is a description of the grammar of Eastern Momu, a language spoken in Papua New Guinea in the north-western province of Sandaun. This is a region with a fair amount of diversity, with several isolates or small language families, and few detailed descriptions. Momu, or Fas as it is more commonly known in the literature, together with the virtually undocumented Baibai language, forms one of these small language families. The thesis is structured such that after a general introduction to the people, language, and region, I give chapters covering: phonology, phonotactics and morphophonemics (Ch. 2), word classes (Ch. 3), nominals (Ch. 4), noun phrases (Ch. 5), verbs (Ch. 6), aspect (ch. 7), grammatical relations (Ch. 8), adverbs (Ch. 9), clauses (Ch. 10), non-verbal predicates (Ch. 11), modality and negation (Ch. 12), serial verb constructions (Ch. 13), compounds and coordination (Ch. 14), subordination (Ch. 15) and complementation (Ch. 16). At first glance, Momu has a relatively uncomplicated five vowel phonology, or ten vowels if one includes length. Glides hold a special position within the phonology, phonotactics and morphophonology, as I have analysed it. Glides interact heavily with adjacent segments including metathesis with adjacent consonants in a predictable fashion. Additional phonetic long high vowels arise from some glide-vowel combinations. Amongst the consonants, there is a bilabial trill. This is an areal feature that is rare amongst the world’s languages. A marked feature of the verbal system, but also areally, is a relatively high count of verbs coding verbal number. Verbal number in Momu is conservatively estimated to occupy 30% of the verbal lexicon, placing it at the upper end of the typological space. The theme of verbal number runs throughout the thesis as its relatively high frequency makes for contrastive behaviour in certain domains. Momu has some classically "Papuan" features such as serial verb constructions and verb-final ordering (albeit not strictly so). This thesis aims to position Momu within the growing body of work describing the incredible features, number and variety of languages of Papua New Guinea, but also to focus on a region within Papua New Guinea with perhaps a higher degree of diversity and lower total count of documentation overall.
Identification Of Novel Î±4Î²2-Nicotinic Acetylcholine Receptor Identification Of Novel Î±4Î²2-Nicotinic Acetylcholine Receptor (Nachr) Agonists Based On An Isoxazole Ether Scaffold That (Nachr) Agonists Based On An Isoxazole Ether Scaffold That Demonstrate Antidepressant-Like Activity Demonstrate A

: There is considerable evidence to support the hypothesis that the blockade of nAChR is responsible for the antidepressant action of nicotinic ligands. The nicotinic acetylcholine receptor (nAChR) antagonist, mecamylamine, has been shown to be an effective add-on in patients that do not respond to selective serotonin reuptake inhibitors. This suggests that nAChR ligands may address an unmet clinical need by providing relief from depressive symptoms in refractory patients. In this study, a new series of nAChR ligands based on an isoxazole-ether scaffold have been designed and synthesized for binding and functional assays. Preliminary structure − activity relationship (SAR) efforts identified a lead compound 43 , which possesses potent antidepressant-like activity (1 mg/kg, IP; 5 mg/kg, PO) in the classical mouse forced swim test. Early stage absorption, distribution, metabolism, excretion, and toxicity (ADME-Tox) studies also suggested favorable drug-like properties, and broad screening toward other common neurotransmitter receptors indicated that compound 43 is highly selective for nAChRs over the other 45 neurotransmitter receptors and transporters tested
Active learning for misspecified generalized linear models

Active learning refers to algorithmic frameworks aimed at selecting training data points in order to reduce the number of required training data points and/or improve the generalization performance of a learning method. In this paper, we present an asymptotic analysis of active learning for generalized linear models. Our analysis holds under the common practical situation of model misspecification, and is based on realistic assumptions regarding the nature of the sampling distributions, which are usually neither independent nor identical. We derive unbiased estimators of generalization performance, as well as estimators of expected reduction in generalization error after adding a new training data point, that allow us to optimize its sampling distribution through a convex optimization problem. Our analysis naturally leads to an algorithm for sequential active learning which is applicable for all tasks supported by generalized linear models (e.g., binary classification, multi-class classification, regression) and can be applied in non-linear settings through the use of Mercer kernels.
Distance-based shape statistics for image segmentation with priors. (Statistiques de formes pour la segmentation d'images avec a priori)

The variational approach in image segmentation consists in defining a criterion depending on a contour and in computing its derivative with respect to the contour in order to minimize it with a gradient descent method. We propose a way to compute shape statistics of a sample set of contours and to incorporate them as a shape prior in the variational framework. We first define the set of "all shapes" as the set of "regular enough" shapes. We study several metrics on it and show they are topologically equivalent. One of them, the Hausdorff distance, is considered in the sequel. With the only knowledge of the distance between shapes we build a low-dimensional map thanks to the graph Laplacian technique. We then build a differentiable approximation of the Hausdorff distance. This allows to define the "mean" shape of a sample set of shapes and to find it with a variational approach. It happens that the notion of "shape gradient" depends strongly on the underlying inner product structure, and that consequently we also have to choose a convenient inner product in order to set priors on the deformation fields that a shape undergoes during the gradient descent process. We then compute statistics based on the instantaneous deformation fields that the "mean shape" should undergo to move towards each example of the sample set of shapes. The application of PCA to the fields leads to sensible characteristic modes of deformation that convey the shape variability. Contour statistics are turned into a shape prior; an example of image segmentation with this criterion is shown. A similar approach is also tried on images instead of contours: eigenmodes are shown for a human face database, and an expression recognition task is performed using SVM on deformation fields.