Miracle-dz/UniFAR-FTUs huggingface dataset:
Patient Retention in Antiretroviral Therapy Programs in Sub-Saharan Africa: A Systematic Review

Background Long-term retention of patients in Africa's rapidly expanding antiretroviral therapy (ART) programs for HIV/AIDS is essential for these programs' success but has received relatively little attention. In this paper we present a systematic review of patient retention in ART programs in sub-Saharan Africa. Methods and Findings We searched Medline, other literature databases, conference abstracts, publications archives, and the “gray literature” (project reports available online) between 2000 and 2007 for reports on the proportion of adult patients retained (i.e., remaining in care and on ART) after 6 mo or longer in sub-Saharan African, non-research ART programs, with and without donor support. Estimated retention rates at 6, 12, and 24 mo were calculated and plotted for each program. Retention was also estimated using Kaplan-Meier curves. In sensitivity analyses we considered best-case, worst-case, and midpoint scenarios for retention at 2 y; the best-case scenario assumed no further attrition beyond that reported, while the worst-case scenario assumed that attrition would continue in a linear fashion. We reviewed 32 publications reporting on 33 patient cohorts (74,192 patients, 13 countries). For all studies, the weighted average follow-up period reported was 9.9 mo, after which 77.5% of patients were retained. Loss to follow-up and death accounted for 56% and 40% of attrition, respectively. Weighted mean retention rates as reported were 79.1%, 75.0% and 61.6 % at 6, 12, and 24 mo, respectively. Of those reporting 24 mo of follow-up, the best program retained 85% of patients and the worst retained 46%. Attrition was higher in studies with shorter reporting periods, leading to monthly weighted mean attrition rates of 3.3%/mo, 1.9%/mo, and 1.6%/month for studies reporting to 6, 12, and 24 months, respectively, and suggesting that overall patient retention may be overestimated in the published reports. In sensitivity analyses, estimated retention rates ranged from 24% in the worse case to 77% in the best case at the end of 2 y, with a plausible midpoint scenario of 50%. Conclusions Since the inception of large-scale ART access early in this decade, ART programs in Africa have retained about 60% of their patients at the end of 2 y. Loss to follow-up is the major cause of attrition, followed by death. Better patient tracing procedures, better understanding of loss to follow-up, and earlier initiation of ART to reduce mortality are needed if retention is to be improved. Retention varies widely across programs, and programs that have achieved higher retention rates can serve as models for future improvements.
Detection of microscopic extracapsular extension prior to radical prostatectomy for clinically localized prostate cancer.

OBJECTIVE To assess better techniques of clinical staging to identify the presence and location of extracapsular extension (ECE) and assist the surgeon in the selection of candidates for resection or preservation of neurovascular bundles during radical prostatectomy. PATIENTS AND METHODS In a retrospective review of the records of 117 patients with clinically localized (31 T1 and 86 T2) prostate cancer treated with radical prostatectomy the results of digital rectal examination (DRE), real-time transrectal ultrasound (TRUS) and a retrospective review of static films were compared to assess their accuracy in the detection of ECE. The ultrasonic criterion for ECE was bulging or irregularity of the boundary echo adjacent to a hypoechoic lesion. On DRE, the criterion for ECE was palpable bulging of a nodule beyond the normal contour of the prostate. The reference standard was the presence and location of ECE in the whole-mount, serially sectioned radical prostatectomy specimens. RESULTS Microscopic ECE was present in 64 of the specimens (55%). There was no significant difference between DRE, prospective TRUS and retrospective TRUS in the overall accuracy of detection of ECE. However, when the results of DRE and TRUS were combined (if either was positive the result was considered positive), the positive predictive value (PPV) was 79% and the sensitivity (91%), with the overall accuracy increased significantly (P < 0.05). CONCLUSION The presence and precise location of microscopic ECE can be determined pre-operatively with reasonable accuracy using real-time ultrasound combined with the results of DRE.
Annoyance Maximization for Digital Cinema Anti-piracy Applications

Data security is a major issue for digital cinema industry. One common way to pirate a movie called "screening" is to use a camcorder of a good quality during the projection, to record the movie and then share it on the Internet. Different strategies have been explored for resolving the problem of securing digital cinema content, some are based on temporal effects, others on colorimetric aspects. The main idea is to insert a mark on the projected data that is invisible to a "normal" human observer but visible on the recorded data allowing to impair the content. Starting from this concept, it is very important to find a way for maximizing annoyance in order to make the pirate copy useless. This paper deals with a strategy for defining insertion maps that increase the annoyance and determining which type of content (text, graphics) is most suitable. So, we developed a method that takes into account the specificities of images and their content to determine such a map. We then managed series of psychophysical tests with a group of normal observers in order to provide recommendations to anti-piracy technology developers to maximize the annoyance dependently on the content of images.
Recombinant lactic acid bacteria as delivery vectors of heterologous antigens: the future of vaccination?

UNLABELLED Lactic acid bacteria (LABs) are good candidates for the development of new oral vaccines and are attractive alternatives to attenuated pathogens. This review focuses on the use of wild-type and recombinant lactococci and lactobacilli with emphasis on their molecular design, immunomodulation and treatment of bacterial infections. The majority of studies related to recombinant LABs have focused on Lactococcus lactis, however, molecular tools have been successfully used for Lactobacillus spp. RESEARCH Recombinant lactobacilli and lactococci have several health benefits, such as immunomodulation, restoration of the microbiota, synthesis of antimicrobial substances and inhibition of virulence factors. In addition, protective immune responses that are well tolerated are induced by the expression of heterologous antigens from recombinant probiotics.
Phase I study of olaratumab in Japanese patients with advanced solid tumors

Olaratumab (IMC‐3G3) is a fully human IgG1 monoclonal antibody that selectively binds the external domain of human platelet‐derived growth factor receptor‐α with high affinity and blocks ligand binding. This was a single‐center, dose‐escalation, phase I trial of olaratumab in Japanese patients with advanced/refractory solid malignancies. Three to six patients were enrolled into each of three cohorts: Patients received i.v. olaratumab: 10 mg/kg on days 1 and 8 every 3 weeks (cohort 1); 20 mg/kg every 2 weeks (cohort 2); and 15 mg/kg on days 1 and 8 every 3 weeks (cohort 3). Doses were escalated from cohort 1 through cohort 3. The primary objective was to establish the safety and pharmacokinetic profile of olaratumab. Sixteen patients were treated across three cohorts. There were no dose‐limiting toxicities, so the maximum tolerated dose was not reached. The most common olaratumab‐related treatment‐emergent adverse events (TEAEs) were proteinuria (25.0%) and elevated aspartate transaminase (12.5%). One patient (cohort 2) had two olaratumab‐related Grade 3 TEAEs (increased aspartate aminotransferase and tumor hemorrhage); otherwise, olaratumab‐related TEAEs were Grade 1/2. Seven patients (43.8%) had a best response of stable disease. Based on the pharmacokinetic concentration profile of olaratumab, the trough concentrations following single and multiple doses at 15 mg/kg on days 1 and 8 every 3 weeks (cohort 3) and multiple doses at 20 mg/kg every 2 weeks (cohort 2) were above the 155 μg/mL target. Thus, these two doses could represent an acceptable schedule for future trials in Japanese patients. Olaratumab had an acceptable safety profile and was well tolerated.
Study of the Moraxella Group I. Genus Moraxella and the Neisseria catarrhalis Group

A number of strains of oxidase-positive moraxellas and of neisserias related to Neisseria catarrhalis were characterized with respect to a number of nutritional and physiological properties and could be assigned to several species or species groups on the basis of their phenotypic traits. This grouping was consistent with that established by Bövre on the basis of transformation frequencies for streptomycin resistance. It is proposed to reserve the generic name Moraxella for the oxidase-positive rodshaped organisms, and a redescription of the genus is offered. Following the recent taxonomic proposals of Bövre and Henriksen, the specific name Moraxella osloensis is applied to the nutritionally unexacting strains that accumulate poly-β-hydroxybutyrate as carbon reserve. The nutritionally exacting strains are assigned to three distinct groups which can be regarded as separate species or as varieties of M. lacunata. The epithets applicable to these groups appear to be lacunata, nonliquefaciens, and bovis. The “false neisserias” could be assigned to at least three subgroups, one of which constitutes the clearly defined entity, N. catarrhalis, which could be distinguished from N. caviae and N. ovis.
An Integrated Framework For The Conceptualisation and Empirical Analysis Of Work-Life Balance

Managing paid work alongside other parts of life has been the focus of research since the 1960s. The terminology has evolved and reflected the changing social, economic and workplace developments and issues that have occurred over the decades, with the worklife balance discourse beginning in the 1990s. Despite the exponential growth in worklife balance research and practice in recent years, the concept remains underdeveloped. The field is hindered by a lack of solid theoretical models and the absence of a psychometrically sound measure of work-life balance. In addition, very few studies have explored the factors that relate to the achievement of successful work-life balance. This research addresses the limitations identified above and is guided by a relevant framework that incorporates two complementary lines of scholarship – demands-andresources theory and work-family interface theory. An integrated conceptualisation and theoretical model of work-life balance is proposed to answer the research questions: How do personal and environmental characteristics contribute to an individual’s perception of work-life balance and to its consequences? and What are the strategies used by individuals who perceive themselves as having successful work-life balance? Consideration is given to the various aspects of work-life balance: personal and environmental contributing factors (demands and resources), work-family interface indicators (conflict and facilitation), the measurement of perceived work-life balance and its relationship with a range of consequences for individuals and organisations (wellbeing, mental health, satisfaction and performance). ; ; Submitted in the fulfilment of the requirements of the degree of Doctor of Philosophy, University of the Sunshine Coast, 2011.
‘APPLIED SOCIALISM OF A FAIRLY MODERATE KIND’

This article analyses general opinions of Scandinavia held by British policymakers in the post‐war period, before going on to examine a particular instance of Britain's attempts to copy ‘Scandinavian policies’ in the early 1960s. Given the generally positive views held as concerned Scandinavian economic and social policies at the time, and the influence those countries wielded in international economic and social policy networks, such attempts were only to be expected. During the 1959–1964 Parliament, the British Conservative Government attempted to adopt housing policies from Scandinavia, in particular housing co‐operatives subsidized by the state, but organized by owners and tenants. They failed to entrench such new ideas in the British policy system, for four reasons. The first was the very strong institutional position of municipal housing and owner‐occupation; the second was the taxation system, which proved impervious to change; the third was the obviously politically‐motivated attempt to change British behaviour in a very short time‐frame; and the fourth, crucially, was the lack of knowledge as to how Scandinavian housing markets actually worked. This failed experiment demonstrates the allure, but also the superficiality and some of the dangers, of direct policy transfer between nations.
Detection of Simple Plagiarism in Computer Science Papers

Plagiarism is the use of the language and thoughts of another work and the representation of them as one's own original work. Various levels of plagiarism exist in many domains in general and in academic papers in particular. Therefore, diverse efforts are taken to automatically identify plagiarism. In this research, we developed software capable of simple plagiarism detection. We have built a corpus (C) containing 10,100 academic papers in computer science written in English and two test sets including papers that were randomly chosen from C. A widespread variety of baseline methods has been developed to identify identical or similar papers. Several methods are novel. The experimental results and their analysis show interesting findings. Some of the novel methods are among the best predictive methods.
Design of Series Connected Forward Fly Back Step up Dc-Dc Converter

Now a days, small scale solar array and PV module is having low voltage. So to connect them to grid, it is necessary to boost the output voltage higher than 300 V. There are some technologies available like high voltage boost converter, soft switching converters. But they have poor reliability due to absence of isolation and low power conversion efficiency. This paper represent a high step up Dc-Dc converter which has series connected forward converter and flyback converter using transformer technology to increase the utilization with an advantage of high system reliability and high power conversion efficiency. In this paper design and analysis of proposed system are presented along with the performance analysis and simulation. Also, a 125 W hybrid Dc-DC converter hardware model has implemented for experimental verification.
Discovering Potential Terminological Relationships from Twitter’s Timed Content

This paper presents a method to discover possible terminological relationships from tweets. We match the histories of terms (frequency patterns). Similar history indicates a possible relationship between terms. For example, if two terms (t1, t2) appeared frequently in Twitter at particular days, and there is a ‘similarity’ in the frequencies over a period of time, then t1 and t2 can be related. Maintaining standard terminological repository with updated relationships can be difficult; especially in a dynamic domain such as social media where thousands of new terms (neology) are coined every day. So we propose to construct a raw repository of lexical units with unconfirmed relationships. We have experimented our method on time-sensitive Arabic terms used by the online Arabic community of Twitter. We draw relationships between these terms by matching their similar frequency patterns (timelines). We use dynamic time warping as a similarity measure. For evaluation, we have selected 630 possible terms (we call them preterms) and we matched the similarity of these terms over a period of 30 days. Around 270 correct relationships were discovered with a precision of 0.61. These relationships were extracted without considering the textual context of the term.
A General G1/S-Phase Cell-Cycle Control Module in the Flowering Plant Arabidopsis thaliana

The decision to replicate its DNA is of crucial importance for every cell and, in many organisms, is decisive for the progression through the entire cell cycle. A comparison of animals versus yeast has shown that, although most of the involved cell-cycle regulators are divergent in both clades, they fulfill a similar role and the overall network topology of G1/S regulation is highly conserved. Using germline development as a model system, we identified a regulatory cascade controlling entry into S phase in the flowering plant Arabidopsis thaliana, which, as a member of the Plantae supergroup, is phylogenetically only distantly related to Opisthokonts such as yeast and animals. This module comprises the Arabidopsis homologs of the animal transcription factor E2F, the plant homolog of the animal transcriptional repressor Retinoblastoma (Rb)-related 1 (RBR1), the plant-specific F-box protein F-BOX-LIKE 17 (FBL17), the plant specific cyclin-dependent kinase (CDK) inhibitors KRPs, as well as CDKA;1, the plant homolog of the yeast and animal Cdc2+/Cdk1 kinases. Our data show that the principle of a double negative wiring of Rb proteins is highly conserved, likely representing a universal mechanism in eukaryotic cell-cycle control. However, this negative feedback of Rb proteins is differently implemented in plants as it is brought about through a quadruple negative regulation centered around the F-box protein FBL17 that mediates the degradation of CDK inhibitors but is itself directly repressed by Rb. Biomathematical simulations and subsequent experimental confirmation of computational predictions revealed that this regulatory circuit can give rise to hysteresis highlighting the here identified dosage sensitivity of CDK inhibitors in this network.
Factors affecting response rates to mailed questionnaires: A quantitative analysis of the published literature.

Two hundred fourteen manipulations of the independent variables in 98 mailed questionnaire response rate experiments were treated as respondents to a survey, yielding a mean final response rate of 60.6% with slightly over two contacts. The number of contacts and the judged salience to the respondent were found to explain 51% of the variance in final response. Government organization sponsorship, the type of population, the length of the questionnaire, questions concerning other individuals, the use of a special class of mail or telephone on the third contact, and the use of metered or franked mail on the outer envelope affected final response independent of contacts and salience. A causal model of the final response rate, including initial response, explaining 90% of the variance, and a regression equation predicting final response rates are presented to show that high response rates are achievable by manipulating the costs of responding and the perceived importance of both the research and the individual response.
Cyclin-Dependent Kinases (Cdk) as Targets for Cancer Therapy and Imaging

Aberration in proliferation and consequently in cell cycle control is a common aspect in carcinogenesis. As master cell cycle regulating proteins in all eukaryotic cells the Cyclindependent kinases (Cdk) were identified by Leland Hartwell, Paul Nurse, and Timothy Hunt in the 1970s and 1980s. Chronological activation of respective Cdk according to respective cell cycle phase G1, S, G2 or M is mediated through association with a regulatory Cyclin subunit, phosphorylation of Cdk and binding of endogenous activators and inhibitors, as well as subcellular localization (Shapiro, 2006). In human cells four Cdk are essential components of the cell cycle machinery with key functions also in human cancer cells: Cdk1, Cdk2, Cdk4, and Cdk6 (Fig. 1) (Malumbres & Barbacid, 2009). First, Cyclin D-dependent kinases Cdk4 and Cdk6 are activated in human cell cycle in response to mitogenic signals to initiate G1 phase progression and prepare DNA duplication in S phase (Malumbres & Barbacid, 2005). Cdk4-Cyclin D or Cdk6-Cyclin D and later also Cdk2-Cyclin E complexes sequentially phosphorylate retinoblastoma proteins (Rb) on different serine and threonine residues. Resulting Rb protein inactivation is required for the transcriptional activation of genes in G1/S phase (Harbour & Dean, 2000). In G1 phase endogenous inhibitors of monomeric Cdk4 and Cdk6 like INK4 and inhibitors of Cdk2/Cdk4/Cdk6-Cyclin complexes like Cip and Kip proteins exert important influence on Cdk catalytic activity (Blain, 2008; Sherr & Roberts, 1999). Once the cell irreversibly passed restriction point R at the end of G1 phase, Cdk2-Cyclin A complex is formed, facilitating orderly execution of S phase events like DNA replication and centrosome cycle through phosphorylation of various proteins (Malumbres & Barbacid, 2005). Activation of Cdk1 by Cyclin A is required for DNA damage checkpoint control, later Cdk1-Cyclin B for G2/ M phase transition and initiation of mitosis, especially chromosome condensation and microtubule dynamics (Malumbres & Barbacid, 2009). Therefore, active Cdk1-Cyclin complexes mediate phosphorylation of about 70 substrates, e. g. , minichromosome maintenance (MCM), p53, lamins, and dyneins. Initiation of cell re-entrance from G0 to G1 phase and early inactivation of Rb is assigned to Cdk3-Cyclin C (Ren & Rollins, 2004). Another Cyclin-dependent kinase, Cdk5, is involved in the regulation of neuronal function (Cruz & Tsai, 2004).
A prospective study of ocular toxicity in patients receiving ethambutol as a part of directly observed treatment strategy therapy

Background and Objectives: India is among the largest countries to implement the revised National Tuberculosis Control Program (RNTCP). This program provides intermittent regimens to the patients, where the doses of isoniazid and ethambutol are more as compared to the daily regimen, which is a cause of concern, particularly with regard to the ocular toxicity of ethambutol. The present study was undertaken to explore the ocular toxicity in the patients registered under the program. Materials and Methods: This was a prospective single center cohort study of 64 patients of categories I and II, coming to the RNTCP-Directly Observed Treatment Strategy (DOTS) center at a tertiary care referral hospital. The detailed history, best corrected visual acuity, fundus examination, and color vision test were carried out in all patients at the start of treatment and then at the first and second month of treatment. Results: Loss in visual acuity from the baseline was noted at the second month follow up in 12 (9.4%) eyes (P = 0.001), visual field defects were seen in eight (6.3%) eyes (P = 0.0412), and optic disc abnormalities were observed in six (4.7%) (P = 0.013) eyes. Color vision abnormalities were noted in 16 (12.6%) eyes (P = 0.003), four eyes showed impairment in red–green color perception, and the others showed impairment in blue–yellow color perception as well. Patients with ocular symptoms were advised to stop ethambutol and they showed improvement in visual acuity after follow up of one to two months. The overall outcome of treatment was not affected by discontinuation of ethambutol in these patients. Conclusion: Ethambutol when taken according to program could cause ocular toxicity. The early recognition of ocular symptoms is important to prevent unnecessary delay in diagnosis and probable irreversible visual loss.