Miracle-dz/UniFAR-FTUs huggingface dataset:
The therapeutic effects of Rho-ROCK inhibitors on CNS disorders

Rho-kinase (ROCK) is a serine/threonine kinase and one of the major downstream effectors of the small GTPase Rho. The Rho-ROCK pathway is involved in many aspects of neuronal functions including neurite outgrowth and retraction. The Rho-ROCK pathway becomes an attractive target for the development of drugs for treating central nervous system (CNS) disorders, since it has been recently revealed that this pathway is closely related to the pathogenesis of several CNS disorders such as spinal cord injuries, stroke, and Alzheimer's disease (AD). In the adult CNS, injured axons regenerate poorly due to the presence of myelin-associated axonal growth inhibitors such as myelin-associated glycoprotein (MAG), Nogo, oligodendrocyte-myelin glycoprotein (OMgp), and the recently identified repulsive guidance molecule (RGM). The effects of these inhibitors are reversed by blockade of the Rho-ROCK pathway in vitro, and the inhibition of this pathway promotes axonal regeneration and functional recovery in the injured CNS in vivo. In addition, the therapeutic effects of the Rho-ROCK inhibitors have been demonstrated in animal models of stroke. In this review, we summarize the involvement of the Rho-ROCK pathway in CNS disorders such as spinal cord injuries, stroke, and AD and also discuss the potential of Rho-ROCK inhibitors in the treatment of human CNS disorders.
Who cares? The importance of interpersonal respect in employees' work values and organizational practices

Two large online surveys were conducted among employees in Germany to explore the importance employees and organizations lay on aspects of interpersonal respect in relation to other work values. The first study (N1 = 589) extracted a general ranking of work values, showing that issues of respect which involve supervisors are rated particularly high among employees. The second study (N2 = 373) replicated the previous value ranking by and large. However, it is shown that the value priorities indicated by employees are not always matched by organizational practices. Especially respect issues which involve employees' supervisors diverge strongly negative. Consequences and potentials for change in organizations are discussed.
The relevance of role models to older aged generation Y consumers

This study assesses the relevance of role models, specifically sports role models, and the related concepts of anti-heroes and gender to Generation Y consumers in the older age group of 18-29 year olds. A qualitative study, following a post-positivist inquiry paradigm was conducted. The specific research strategy used was grounded theory, utilising deductive thought processes coupled with the process of constant comparison. A series of semi-structured in-depth interviews were carried out. Results suggest that direct relevance to the subject under investigation is a key determinant of role model choice. Gender is also found to have significant effect, as is media, both in the creation of role models and anti-heroes.
3.8 /spl times/ 3.8 mm/sup 2/ PCS-CDMA duplexer incorporating thin film resonator technology

Bulk acoustic wave (BAW) technology based on piezoelectric thin films has recently emerged as a preferred technology for the realization of miniaturized high performance RF filters and duplexers for wireless applications like mobile telephones. We present a duplexer for PCS-CDMA applications with a footprint of 3.8 mm /spl times/ 3.8 mm and a height of 1.1 mm. The duplexer consists of a transmit (TX) and a receive (RX) filter, both mounted as bare dies on a low temperature co-fired ceramic (LTCC) multilayer substrate incorporating additional matching elements. The filters are realized using solidly mounted resonator (SMR) technology, where an acoustic mirror separates the active resonator part from the substrate. Duplexer packaging is based on the EPCOS proprietary CSSP technology developed for the miniaturization of chip sized SAW packages including a cavity between the package and the acoustically active filter areas. The front-end technology for realizing the RF filters uses standard 200 mm CMOS technology and the deposition of AlN piezoelectric thin films with high thickness uniformity over the wafer. The duplexer is fully matched to 50 ohms with low insertion attenuation in the pass band, a superior stop band characteristic up to 10 GHz, and a temperature coefficient of frequency (TCF) of -20 ppm/K.
Inteligência e rendimento escolar: contingências de um relacionamento menos óbvio no final da adolescência

The relationship between cognitive abilities and school achievement are shown, yet not always enough understood and explained due to the diversity of variables involved in academic performance. Therefore, considering the results of a standardization study on Reasoning Tests Battery (RTB Version 10/12), we analyzed their correlation with school performance indicators (ratings in Portuguese Language and Mathematics subjects as well as the number of years of school failure) of secondary school students. The study involves a national sample of students (n = 1050) divided by 10th (n = 449), 11th (n = 315) and 12th (n = 286) school grades, properly stratifi ed and randomly selected. The results suggest variations in the correlation coeffi cients obtained according to the nature of the cognitive tests used (type of content’s item), the specifi c indicators of school performance, the school grade, the curriculum’s course and the gender of students. Furthermore, the correlations decrease as one advances in school grade, in such a way that one can fi nd higher results among female students and those who had chosen Humanities curriculum course. This decrease points out that, as students go along school grades, other variables beyond intellectual abilities assume a growing importance in academic achievement. KEY-WORDS: Intelligence, School achievement, Adolescence, Schooling
Application of circle criteria for stability analysis of linear SISO and MIMO systems associated with fuzzy logic controller

The concept of the sector bound nonlinearity has been considered for frequency domain stability analysis of linear single-input single-output (SISO) and decoupled multi-input multi-output (MIMO) systems associated with the fuzzy logic controller. For analysis of the fuzzy logic controller, the system's model is considered to be available in transfer-function form, but for generation of the fuzzy logic controller no model description is necessary. A generalized Nyquist-type stability analysis is presented.
The effects of language transfer in Turkish EFL learners

Language transfer is defined as the influence resulting from similarities and differences between the target language and any other language that has been previously (and perhaps imperfectly) acquired (Odlin, 1989). The notion of transfer was raised with the Contrastive Analysis Hypothesis (CAH) by the behaviorist psychologists. According to this view, native language (NL) affects second language and it was the source of error in production and/or reception (Gass & Selinker, 2001). The present study aims to investigate the transfer effects of Turkish (L1) learners of English (L2). Specifically, the present study examines the acquisition of word order (verb placement) in Turkish EFL learners. The participants were 19 Turkish EFL learners enrolled in a Language Preparatory Program at a private university in Turkey. Data came from picture description and grammaticality judgment tasks. The results revealed significant evidence for syntactic transfer due to different word order patterns between the two languages.
Selection of sentence set for vietnamese audiovisual corpus design

This paper describes a work on selecting a sentence set, which are used for designing an audio-visual speech corpus for Vietnamese language in developing an Audio-Visual Speech Recognition system. An iterative procedure combined with some additional conditions was applied to an original sentence set of 540,744 sentences to select a minimum sentence set.
A 2.4-GHz low-power all-digital phase-locked loop

This paper presents a 2.4-GHz all-digital phaselocked loop (ADPLL) frequency synthesizer for wireless applications. The ADPLL is built around a digitally controlled LC oscillator, and it covers the target frequency range with fine frequency resolution. In the feedback path, a high-speed topology is employed for the variable phase accumulator to count full cycles of the RF output. A simple technique based on a short delay line in the reference signal path effectively lowers power consumption of the time-to-digital converter (TDC) and reduces in-band spurs of the output spectrum. Fabricated in a 65-nm CMOS, the ADPLL has an active area of 0.24 mm2. Measured output frequency range is from 2.29 to 2.92 GHz. The worstcase phase noise at 1-MHz offset over the whole frequency range is −120 dBc/Hz when the PLL consumes 12 mW from a 1.2-V supply, and −112 dBc when power is lowered to 8 mW. The inband spurs are below −61 dBc, and far-off spurs below −57 dBc.
The Recurrent Temporal Restricted Boltzmann Machine

The Temporal Restricted Boltzmann Machine (TRBM) is a probabilistic model for sequences that is able to successfully model (i.e., generate nice-looking samples of) several very high dimensional sequences, such as motion capture data and the pixels of low resolution videos of balls bouncing in a box. The major disadvantage of the TRBM is that exact inference is extremely hard, since even computing a Gibbs update for a single variable of the posterior is exponentially expensive. This difficulty has necessitated the use of a heuristic inference procedure, that nonetheless was accurate enough for successful learning. In this paper we introduce the Recurrent TRBM, which is a very slight modification of the TRBM for which exact inference is very easy and exact gradient learning is almost tractable. We demonstrate that the RTRBM is better than an analogous TRBM at generating motion capture and videos of bouncing balls.
Is profit sharing investment account a deposit? The case of Institutions offering Islamic Finance

This paper provides a conceptual discussion on the impact of regulatory requirements on deposit behaviors as exemplified by prescribed guidelines and regulations. It is postulated that given the distinguishing nature of profit sharing investment account (PSIA), the reporting requirements for existing deposits may not ensure information content of PSIA are effectively communicated to Investment Account Holders (IAH). Key distinguishing financial intermediation feature between IIFS and conventional banks is compared to describe and discuss the nature and classification of deposit and PSIA. The term “deposit” extends to a broad class of deposits including PSIA, suggests the need to examine the regulatory reporting requirements affecting information disclosure. Distinctions in the treatments on PSIA by Institutions offering Islamic Finance (IIFS) and that of deposit in the conventional counterpart, found in the literature are explored. Regulation and policy issues in the mobilization of PSIA and on the need for transparency in the PSIA related disclosures with supervisory and governance mechanisms are analysed. The issue is to what extent present practice in the treatment of PSIA ensures appropriate information content of PSIA to assist informed decision by IAH. The paper concludes with the need to examine the contents of regulatory guidelines to ascertain whether based on the effect of the interpretation of regulatory guidelines by the IIFS, PSIA is a deposit. This has consequential effect on behavior of the deposit and that of equity type deposits (PSIA). Existence of any regulatory disclosure gap in the prescribed guidelines; and likelihood of ‘skewed interpretations’ on the part of (IIFs), would stifle the potential growth of PSIA. Similarly, the existence of any ‘skewed interpretations’ on the part of IIFS would provide opportunity for manipulative behavior in the management of PSIA
Effects of papillary muscle position on in-vitro dynamic strain on the porcine mitral valve.

BACKGROUND AND AIM OF THE STUDY Improved knowledge of mitral valve (MV) mechanics is essential to understand normal MV function and design and evaluate new surgical repair procedures. Initially, the dynamic deformation of the central region of the porcine MV anterior leaflet was quantified under simulated physiological conditions to explore the effects of varying papillary muscle (PM) position. METHODS Fresh porcine MVs were mounted in an in-vitro physiological flow loop. The PM positions were set to normal, taut, and slack states to simulate physiological and pathological PM positions. Leaflet deformation was measured by tracking the displacement of 16 markers (approximately 250 microm diameter) placed in a 5 x 5 mm section of the central region of the anterior leaflet, approximately 5 mm from the annulus and coaptation line. Local leaflet tissue strain and strain rates were calculated from measured displacements under dynamic loading conditions. A total of 11 mitral valves was studied. RESULTS Under the normal PM positional state, the average areal strain rate during valve closure was typically approximately 620% per second. While not measurably altering the maximal areal strain rate, the slack PM position led to a delay in complete valve closure and more rapid leaflet loading (defined as delta transvalvular pressure/delta areal strain) in late systole compared to the other two PM positions. CONCLUSION It was shown that PM position influenced the MV loading process in the central area of the anterior leaflet. The slack PM position led to a delay in complete valve closure and more rapid leaflet loading in late systole. This increase in loading rate may have long-term consequences in MV function.
PolySearch: a web-based text mining system for extracting relationships between human diseases, genes, mutations, drugs and metabolites

A particular challenge in biomedical text mining is to find ways of handling ‘comprehensive’ or ‘associative’ queries such as ‘Find all genes associated with breast cancer’. Given that many queries in genomics, proteomics or metabolomics involve these kind of comprehensive searches we believe that a web-based tool that could support these searches would be quite useful. In response to this need, we have developed the PolySearch web server. PolySearch supports >50 different classes of queries against nearly a dozen different types of text, scientific abstract or bioinformatic databases. The typical query supported by PolySearch is ‘Given X, find all Y's’ where X or Y can be diseases, tissues, cell compartments, gene/protein names, SNPs, mutations, drugs and metabolites. PolySearch also exploits a variety of techniques in text mining and information retrieval to identify, highlight and rank informative abstracts, paragraphs or sentences. PolySearch's performance has been assessed in tasks such as gene synonym identification, protein–protein interaction identification and disease gene identification using a variety of manually assembled ‘gold standard’ text corpuses. Its f-measure on these tasks is 88, 81 and 79%, respectively. These values are between 5 and 50% better than other published tools. The server is freely available at http://wishart.biology. ualberta.ca/polysearch
How the tone and wording of advertisements interact

This research investigates how the tone and wording of advertisements interact. This previously neglected area of research is explored in the context of television advertisements for mobile phones. Reports on an experiment with two independent variables – affective tone and message framing – shows how these variables interact regarding attitudes towards the ad, and recall, for a New Zealand sample. Results suggest that incongruous matching works best, namely happy ads with negative frames, and sad ads with positive frames, providing new insights for advertising practitioners and academics. Theoretical and managerial implications and directions for future research are also discussed.
Partial pole assignment for the quadratic pencil by output feedback control with feedback designs

In this paper we study the partial pole assignment problem for the quadratic pencil by output feedback control where the output matrix is also a designing parameter. In addition, the input matrix is set to be the transpose of the output matrix. Under certain assumption, we give a solution to this partial pole assignment problem in which the unwanted eigenvalues are moved to desired values and all other eigenpairs remain unchanged. Copyright © 2005 John Wiley & Sons, Ltd.
Wideband omnidirectional printed dipole array antenna

In this paper a wideband omnidirectional printed dipole array antenna with high gain is proposed by cascading the double side printed twin dipoles. The measured relative bandwidth for VSWR<1.5 or S11<-14 dB reaches 10% (3893 MHz~4314 MHz), and the measured gain is in a range of 7.71~9.31 dB, with a variation of 1.6 dB.
Commitment Devices: Nice or Mean Means

Commitment devices are regularly celebrated as an easy-to-use, budget way to dodge self-control problems. Analysis of a BA©nabou and Tirole-style signaling game (2004) casts doubts on this view. Adding a commitment device to the standard model reveals difficulties: An agent relying on a commitment device to restrain his future self is less restrained in the present. Committing to do an unpleasant activity in the future leads to procrastination as the signaling effect of doing it now disappears. Therefore some agents may be better off without access to commitment devices. Policy implications are discussed.
A software agent for adaptive navigation support in a restricted internet area

This thesis deals with the development of a software system that helps a user to search for information in the World Wide Web. The particular problem considered here is support in a well-defined, restricted Web area. Two support strategies are considered. One strategy is to present a visitor views of a local hyperlink structure depending on the current position in hyper-space and previous navigation decisions. Main partial problems to realize such a support are dealt with, like the registration of user behavior, the registration of information about the Web area and the presentation of support information on the client side. In contrast to similar systems, the developed system may be applied by a large fraction of Internet users instantly. The only requirement on the client side is Java support by the browser. The second considered support strategy is an estimation of the relevance of data objects and sequences in the Web for a specific client. This estimation is based on the client's previous navigation behavior and registered navigation behavior of other users (collaborative filtering). The approach to estimate relevant data objects in this thesis is to predict a user's future data requests. For this purpose the presented system stores user information on the server side. User behavior is modeled by graphs, consisting of nodes representing requested data objects and edges representing transitions. A new method is presented to predict future navigation steps that is based on a distribution estimation of registered graphs and a classification of a new (partial) navigation profile with regard to the estimated distribution. The different steps of the presented algorithm are evaluated using generated and observed profiles.
Spectral clustering with inconsistent advice

Clustering with advice (often known as constrained clustering) has been a recent focus of the data mining community. Success has been achieved incorporating advice into the k-means and spectral clustering frameworks. Although the theory community has explored inconsistent advice, it has not yet been incorporated into spectral clustering. Extending work of De Bie and Cristianini, we set out a framework for finding minimum normalised cuts, subject to inconsistent advice.
ASSESSMENT OF BENZIMIDAZOLE RESISTANCE STATUS IN AN ORGANIZED GOAT FARM BY EGG HATCH ASSAY

Regular monitoring of benzimidazole resistance status helps in timely implementation of resistance mitigation strategies in farms. Egg hatch assay (EHA) evaluates the ability of benzimidazoles to inhibit or prevent embryonation and hatching of nematode eggs and is the standard in vitro test for detection of benzimidazole resistance. The present study reports detection of benzimidazole resistance in an organized goat farm in Kerala by EHA. Log-probit analysis revealed ED50 of 0.25 μg/ ml thiabendazole which indicated benzimidazole resistance in the farm. The assay was also interpreted using the discriminating dose criterion. Hatching ratio of strongyle eggs (Hdd) at the discriminating dose of 0.1 μg/ml was 0.62 indicating benzimidazole resistance. EHA was found to be a rapid, economic and convenient detection method suitable for routine evaluation of benzimidazole resistance. Detection of benzimidazole resistance in the farm warrants implementation of strategies to control further progression of resistance.
Toward a Unified Criminology: Integrating Assumptions about Crime, People and Society

Preface 1 A Divided Criminology 2 The Scope of the Discipline: What Is Crime? 3 Determinism versus Agency: Is Crime the Result of Forces beyond the Individual's Control or Free Choice? 4 The Nature of Human Nature: Are People Self-Interested, Socially Concerned, or Blank Slates? 5 The Nature of Society: Is Society Characterized by Consensus or Conflict? 6 The Nature of Reality: Is There an Objective Reality That Can Be Accurately Measured? 7 A Unified Criminology Notes Bibliography Name Index Subject Index About the Author
Measuring and modeling computer virus prevalence

To understand the current extent of the computer virus problem and predict its future course, the authors have conducted a statistical analysis of computer virus incidents in a large, stable sample population of PCs and developed new epidemiological models of computer virus spread. Only a small fraction of all known viruses have appeared in real incidents, partly because many viruses are below the theoretical epidemic threshold. The observed sub-exponential rate of viral spread can be explained by models of localized software exchange. A surprisingly small fraction of machines in well-protected business environments are infected. This may be explained by a model in which, once a machine is found to be infected, neighboring machines are checked for viruses. This kill signal idea could be implemented in networks to greatly reduce the threat of viral spread. A similar principle has been incorporated into a cost-effective anti-virus policy for organizations which works quite well in practice. <<ETX>>
Classification of energy-saving operations from the perspective of system management

System management operations consist of detecting events that have occurred in a monitored system, checking system conditions, judging appropriate actions to be taken, and implementing the chosen actions. There are several patterns of system management operations. In this paper, the authors classify energy-saving operations in data centers according to patterns of system management operations. This classification helps enterprises consider what kind of energy-saving operations are feasible in current system management environments and what kind of improvement should be made in order to implement desired energy-saving operations. Use cases are provided for each pattern of system management operations. A quantitative estimation of power consumption reduction and analysis for improvement based upon the estimation are provided for one use case.