Miracle-dz/UniFAR-FTUs huggingface dataset:
Vascular dysfunction in adriamycin nephrosis: different effects of adriamycin exposure and nephrosis.

BACKGROUND Nephrosis-induced endothelial dysfunction is assumed to play a main role in cardiovascular morbidity. Adriamycin-induced proteinuria is a well-established rat model for nephrotic syndrome. However, induction of nephrosis by intravenous adriamycin administration might exert direct adriamycin cardiovasculotoxicity that could obscure or modify nephrosis-induced vascular dysfunction. The present study, therefore, investigated in vitro vascular function in the isolated thoracic aorta and isolated perfused hearts of rats with adriamycin nephrosis, as compared to non-nephrotic adriamycin exposed rats. METHODS Adult rats received a single slow intravenous injection of either adriamycin (1.5 mg/kg, adriamycin nephrotic rats) or saline (healthy controls). In a third group of rats, the cardiovascular system, but not the kidneys, were exposed to adriamycin by transient clipping of renal arteries during adriamycin injection (adriamycin control rats). RESULTS Exposure of the kidneys to adriamycin induced severe proteinuria with corresponding systemic nephrosis, as apparent from hypercholesterolaemia. Adriamycin exposure of the vascular bed led to marked blunting of the aortic response to the endothelium-dependent vasodilator, acetylcholine (ACh), both in non-nephrotic and nephrotic rats. The nephrotic state reduced the bradykinin-induced increase in coronary flow and enhanced the aortic constrictor response to angiotensin II associated with reduced basal aortic NO-activity, as shown by the comparison between adriamycin nephrotic rats and healthy and adriamycin controls. CONCLUSIONS Vascular adriamycin exposure and nephrosis affect vascular function in a distinct and qualitatively different fashion in adriamycin-induced nephrotic syndrome. The differential effects of nephrosis and vascular adriamycin exposure have to be accounted for in the interpretation of vascular studies in adriamycin nephrosis.
Keeping Continuous Deliveries Safe

Allowing swift release cycles, Continuous Delivery has become popular in application software development and is starting to be applied in safety-critical domains such as the automotive industry. These domains require thorough analysis regarding safety constraints, which can be achieved by the execution of safety tests resulting from a safety analysis on the product. With continuous delivery in place, such tests need to be executed with every build to ensure the latest software still fulfills all safety requirements. Even more though, the safety analysis has to be updated with every change to ensure the safety test suite is still up-to-date. We thus propose that a safety analysis should be treated no differently from other deliverables such as source-code and dependencies, propose guidelines to adopt this and formulate implications for the development process.
Coho salmon productivity in relation to salmon lice from infected prey and salmon farms

Summary 1. Pathogen transmission from open net-pen aquaculture facilities can depress sympatric wild fish populations. However, little is known about the effects of pathogen transmission from farmed fish on species interactions or other ecosystem components. Coho salmon Oncorhynchus kisutch smolts are susceptible hosts to the parasitic salmon louse Lepeophtheirus salmonis as well as a primary predator of juvenile pink Oncorhynchus gorbuscha salmon, a major host species for lice. 2. We used a hierarchical model of stock-recruit dynamics to compare coho salmon population dynamics across a region that varies in salmon louse infestation of juvenile coho and their pink salmon prey. 3. During a period of recurring salmon louse infestations in a region of open net-pen salmon farms, coho salmon productivity (recruits per spawner at low spawner abundance) was depressed approximately sevenfold relative to unexposed populations. Alternate hypotheses for the observed difference in productivity, such as declines in coho prey, perturbations to freshwater habitat or stochasticity, are unlikely to explain this pattern. 4. Lice parasitizing juvenile coho salmon were likely to be trophically transmitted during predation on parasitized juvenile pink salmon as well as directly transmitted from salmon farms. 5. Synthesis and applications. The finding that species interactions may cause the effects of pathogen transmission from farmed to wild fish to propagate up a marine food web has important conservation implications: (i) the management of salmon aquaculture should consider and account for species interactions and the potential for these interactions to intensify pathogen transmission from farmed to wild fish, (ii) the ecosystem impact of louse transmission from farmed to wild salmon has likely to have been previously underestimated and (iii) comprehensive monitoring of wild salmon and their population dynamics in areas of intensive salmon aquaculture should be a priority to determine if open net-pen salmon aquaculture is ecologically sustainable.
Behavioral programming of autonomous characters based on probabilistic automata and personality

This paper presents a system for realistic behavioral programming of virtual characters, based on personality and probabilistic automata. We describe personality by using the Five‐Factor Model and achieve autonomy through a goal‐oriented approach. Each character perceives the surrounding world, decides how to behave and acts on the environment according to its personality and to its goals. The chief idea explored by the proposed approach is that personality has a probabilistic influence on behavior selection instead of a deterministic one. Different behavior sequences available to achieve a goal are modeled using probabilistic automata and making probability dependent on character personality. This leads to non‐repetitive behaviors, whose evolution is not foreseeable. The paper first motivates the approach in the context of cybertherapy. Then, it summarizes related work and illustrates in detail the proposed approach. Finally, it presents obtained results and discusses the main limitations of the implemented system. Copyright © 2004 John Wiley & Sons, Ltd.
Data Integration Needs an Industrial Revolution

The data resources in a large enterprise typically exist as many separate islands of data. Each is maintained by a distinct community for its purposes, and is largely unusable by others. It is common to see whole data archipelagos comprised of thousands of separate resources [Ston00]. We would, of course, prefer to see one single integrated data resource usable by all. This is the “grand vision” of data integration: discovery of and access to all data, with multiple sources properly combined, delivered in a form that each consumer can interpret. Decentralized organizations such as the US Air Force might accept for now a slightly less ambitious dream – the ability to establish a connection between islands, a way to obtain any desired information from any other source.
THE USE OF CHORAL READING STRATEGY IN TEACHING READING COMPREHENSION(An Experimental Research at Second Grade of SMPN 4 Pandeglang)

This research investigates the use of chor al reading strategy in reading lesson, specifically it is written in the v title of this research paper. This research is aimed for finding out reading comprehension of the second grade student‟s of SMPN 4 Pandeglang who use choral reading strategy; findin g out reading comprehension of the second rade student‟s of SMPN 4 Pandeglang who do not use choral reading strategy; and knowing whether the student‟s taught through choral reading strategy have better comprehension in reading than those who are taught th rough non choral reading strategy. Method used for this research is experimental with two classes, called experimental and control class using pre test and post test tec hnique. This reseach involves 76 student‟s as a sample among second class of SMPN 4 Pan deglang year 2018 as population. The result of this research shows that the student‟s reading comprehension who use choral reading strategy achieve better than those who do not use use choral reading strategy
Security Policy Management Process within Six Sigma Framework

This paper presents a management process for creating adaptive, real-time security policies within the Six Sigma (6σ) framework. A key challenge for the creation of a management process is the integration with models of known Industrial processes. One of the most used industrial process models is Six Sigma which is a business management model wherein customer centric needs are put in perspective with business data to create an efficient system. The security policy creation and management process proposed in this paper is based on the Six Sigma model and presents a method to adapt security goals and risk management of a computing service. By formalizing a security policy management process within an industrial process model, the adaptability of this model to existing industrial tools is seamless and offers a clear risk based policy decision framework. In particular, this paper presents the necessary tools and procedures to map Six Sigma DMAIC (Define-Measure-Analyze-Improve-Control) methodology to security policy management.
A Simple, Accurate Texture Model for Woven Cotton Cloth

Apparatus for transferring, not only the fuel assemblies, but other component assemblies including control-rod assemblies, thimble-plug assemblies, poison assemblies and the like during refueling of a nuclear reactor. The apparatus includes an outer mast for guiding and protecting the component assemblies which are transferred, an inner mast movable vertically within the guiding mast. The inner mast has grippers for engaging and lifting or lowering fuel assemblies. The outer mast has internal grooved rollers along its length. The inner mast is formed at oppositely facing channels held in a rigid assembly by plates to which the channels are secured. Opposite corners formed by the flanges and the webs of the channels penetrate into the grooves of the rollers and the inner mast is guided and held in position by the rollers. The apparatus also includes an elongated tube within the inner mast movable vertically relative to the inner mast. The tube has a grapple or gripper for engaging and lifting or lowering the component assemblies other than the fuel assemblies. The tube is penetrated by an actuator rod which locks the grapple to the component assemblies. The tube is driven upwardly or downwardly by a winch. The tube carries a primary set of lugs. The inner mast has a plate with an opening through which the lugs pass when the tube alone is driven upwardly. The plate carries a pivotal yoke which is movable between a first or closed position in which the yoke extends over the opening and a second or open position when it does not extend over the opening. In the closed position the yoke is engageable by the primary lugs so that when the tube is raised the inner mast is also raised. The tube also has secondary lugs. The inner mast carries a stop engageable by the secondary lugs when the tube is in a vertical position in which it has raised a component assembly within the masts. The engagement of the secondary lugs and plate serves to pull the inner mast into the guiding mast.
Efeitos riqueza da política monetária : evidência para o Reino Unido

In this work, I analyse the empirical relationship between monetary policy and aggregate wealth using quarterly data for the UK. In this context, I show that a positive shock to the interest rate leads to a fall in aggregate wealth. However, while there is a quick adjustment from nancial wealth, the adjustment of housing wealth is slow. Additionally, an increase in the interest rate generates a ight towards assets that are less liquid, such as housing and/or stocks. The research presented also allows one to conclude that the independence of the Bank of England has reduced uncertainty about the conduct of monetary policy and, as a result, has bene ted economic activity and householdswealth. Finally, the occurrence of nancial crises, stock market crashes and periods of economic and nancial instability partially a¤ects the impact of the interest rate on economic activity. After accounting for such episodes, the e¤ect of a positive shock to the interest rate on GDP and aggregate wealth is smaller in magnitude. Keywords: monetary policy, interest rate, wealth e¤ect, nancial wealth, housing wealth. JEL Classi cation: E21, E43, E51, E53.
Bus Network Design Using Genetic Algorithm

The bus network design problem is an important problem in transportation planning. It is the problem of determining a network of bus lines which best achieves a predetermined objective. This may be done with or without the presence of rapid transit lines. This study is devoted to solving this problem using genetic algorithm. The fitness function is defined as the benefit to the users of the bus network less the cost of the operator of the network, which is to be maximized subject to constraints that properly distribute bus routes over the study area. Objective function calculation depends on the basic data of the city and its bus lines and does not need traffic assignment results. So, it is calculated quickly and it makes the genetic algorithm operation faster. Several good solutions were generated through a sensitivity analysis by changing the parameters of the problem affecting bus route geographical distribution. A network assignment problem was solved for each of the alternative bus networks and several measures of effectiveness were evaluated for them. A multi-objective analysis (concordance analysis) was performed based on 10 measures of effectiveness and 14 weighting systems. As a result, a bus network was proposed for the city of Mashad, Iran.
Beliefs Regarding Fundamental Value and Optimal Investing ∗ Bradford Cornell †

Standard optimal portfolio selection models take no account of the special information that active investors believe they possess. For example, active investors who believe they can place bounds on the price of a security will want to use that information when assessing risk and expected return in order to construct an optimal portfolio. In this paper, we use two continuous-time models to analyze how placing boundaries on the price of a stock affects assessed risk, expected returns, and the optimal holdings of an active investor, and how those vary as a function of the relation between the stock price and the boundaries. In particular, the optimal strategy takes significant long/short positions as the price nears its lower/upper boundary.
Yield maximization for system-level task assignment and configuration selection of configurable multiprocessors

Configurable multiprocessor system is a promising design alternative because of its high degree of flexibility, short development time, and potentially high performance under constraints and challenges driven by applications. An important design challenge at 45nm for multi-core system is manufacturing process variation. Due to increasing concern of WID variation, designers will have to choose configurations of processing cores that maximize yield of the system while not affecting performance and throughput constraints. Due to interdependency between processor configuration selection and task allocation and its impact on yield and latency constraints, we tackle both problems simultaneously. In this paper, we propose the problem of task allocation and configuration selection for yield optimization. We prove the problem is NP-hard and propose an optimal pseudo-polynomial on Serial-Parallel graphs. We target streaming applications in pipelined reconfigurable multiprocessor systems. We provide a case study of configurable Leon processors as the cores implemented on FPGA. Results show that proposed problem could result in significant improvement of the timing yield of the system by exploiting extra slack on tasks.
Supporting system-level power exploration for DSP applications

System-level power exploration requires tools for estimation of the overall power consumed by a system, as well as a detailed breakdown of the consumption of its main functional blocks. We focus on power estimation for data-dominated systems specified as synchronous data-flows and implemented on a single-processor architecture. Our estimator is integrated within the Ptolemy design environment, and provides information to system designers on the power dissipated by every task in a given specification. Power estimation is based on instruction-level power models. We demonstrate the applicability of our tool on a few design examples and target architectures.
An Overview of Vocational Education and Training in Australia and Its Links to the Labour Market.

The purpose of this paper is to describe Australia’s vocational education and training (VET) system and how it relates to the broader set of education and learning options that are available to Australians. Only post-compulsory education and training will be considered here; that is, learning that applies from the age of 15 or 16 years upwards. The initial part of the paper describes the ‘concept’ of VET, including the economic and social context in which it is placed. The following section focuses on linkages between VET and the labour market and the economy, and in particular how these factors influence the supply and demand for skills. The governance and architecture arrangements in place in the VET sector are discussed in the next section along with current policy and planning initiatives. The paper concludes by providing some commentary on future developments.
A multivalued storage system using memristor

For many years the only known passive circuit elements were resistor, inductor and capacitor. In 1971, Leon Chua showed using argument that there should exist another passive element which he named memristor. It is basically a resistor whose resistance increases when current flows through it from one direction and decreases when current flows from the other direction. After 37 years researchers of HP became able to build world's first working memristor and surprised the electronics community. Chua proved that the characteristics of a memristor cannot be simulated using resistor, capacitor and inductor only and hence it is a fundamental element. Many new types of circuits can be built using memristor in it. But as it is a very new element so the no. of circuits is only a few. As memristor can have many resistance levels, we can use some discrete value as different logic level and thus can use in multivalued logic system. In this paper a method has been shown to achieve those different levels. Using this method we can use an array of memristor for making a non-volatile multivalued data storage system‥
Cooperative Control and Active Interfaces for Vehicle Assitsance and Automation

Enabled by scientific, technological and societal progress, and pulled by human demands, more and more aspects of our life can be assisted or automated by technical artefacts. One example is the transportation domain, where in the sky commercial aircraft are flying highly automated most of the times and where on the roads a gradual revolution takes place towards assisted, highly automated or even fully automated cars and trucks. Automobiles and mobility are changing gradually towards intelligent vehicles embedded in an integrated, intelligent transportation system. On the one hand, assistance and automation can have benefits like higher safety, lower workload, or a special fascination of use. On the other hand, assistance and automation come with a couple of challenges especially regarding the interplay between the driver and the assistance/automation. Some of these challenges can be addressed with a close coupling of assistance/automation and the driver, which leads to a shared or cooperative control of the vehicle. An early example of cooperative control in a car is the Lane Keeping Assistant System LKAS, where the automation delivers about 80% of the force required to keep the vehicle on the road, while the driver has to provide the missing 20% and therefore stays in the loop. A combination of LKAS and ACC (Adaptive Cruise Control) leads to highly automated driving, one level of automation on the automation spectrum between manual and fully automated driving. A close coupling between automation and driver can be achieved with active interfaces, e.g. force feedback steering wheels like in the LKAS or active sidesticks. After a brief overview on active interface technology, a prototype system developed in the H-Mode project by NASA, DLR and TU-Munich, and first data gained in driving simulators will be described.
Educational interventions for prevention of healthcare-associated infection: A systematic review

Background:Healthcare-associated infections (HCAIs) are associated with considerable morbidity and mortality. Education of healthcare providers is a fundamental measure to prevent HCAI. Objective:To perform a systematic review to determine the effect of educational strategies of healthcare providers for reducing HCAI. Data Source:Multiple computerized databases for the years 1966 to November 1, 2006, supplemented by manual searches for relevant articles. Study Selection:English-language controlled studies and randomized trials that included an educational intervention and provided data on the incidence of one or more kinds of HCAIs were included. Data Extraction:Data were extracted on study design, patient population, type of intensive care unit, details of the educational intervention, target group for intervention, incidence of HCAI, duration of follow-up, and costs of intervention. Both investigators abstracted data using a standard data abstraction form; study quality was also assessed. Data Synthesis:A total of 26 studies used a number of different educational programs targeting varied study populations of healthcare providers to determine their effect on HCAI rates. Most were pre–post intervention studies and were implemented in the intensive care setting. There was a statistically significant decrease in infection rates after intervention in 21 studies, with risk ratios ranging from 0 to 0.79. The beneficial effect of education was apparent in teaching and nonteaching institutions and in lesser-developed countries and developed nations. Limitations:Only English language studies were included. Because of the study designs and limitations of the individual studies, a causal association between educational interventions and reduced HCAI rates cannot be made. Conclusions:The implementation of educational interventions may reduce HCAI considerably. Cluster randomized trials using validated educational interventions and costing methods are recommended to determine the independent effect of education on reducing HCAI and the cost-savings that may be realized with this approach.
Facebook Distributed System Case Study For Distributed System Inside Facebook Datacenters

Facebook is recognized as the largest online social network system in the last few years, which is come up with billions numbers of users in the last 2013. The system is recognized as distributed system in its design, infrastructure and architecture . The datacenters behind this network system are huge, robust, keeping the system scalable, reliable, secure, and let the Facebook accessible from anywhere with highly availability
Preliminary Usability Assessment of the Map Interface of the Election Incident Reporting System ( EIRS )

I describe a preliminary usability assessment of the Election Incident Reporting System’s (EIRS) map-based incident reporting tool conducted as a final project in a graduate course on Needs Assessment and Usability at the University of California at Berkeley. I used qualitative interviews, taskbased heuristic evaluation and cognitive walkthrough user testing to evaluate the usability of the interface. I find that while EIRS behaved remarkably well during the last election, there could be improvements in consistency, efficiency, the arrangement of visual elements and volunteer training which would deliver a smoother user experience and more functional user interface.