Miracle-dz/UniFAR-FTUs huggingface dataset:
A Note on Mathematical Modelling of Practical Multicampaign Assignment and Its Computational Complexity

Within personalized marketing, a recommendation issue known as multicampaign assignment is to overcome a critical problem, known as the multiple recommendation problem which occurs when running several personalized campaigns simultaneously. This paper mainly deals with the hardness of multicampaign assignment, which is treated as a very challenging problem in marketing. The objective in this problem is to find a customer-campaign matrix which maximizes the effectiveness of multiple campaigns under some constraints. We present a realistic response suppression function, which is designed to be more practical, and explain how this can be learned from historical data. Moreover, we provide a proof that this more realistic version of the problem is NP-hard, thus justifying to use of heuristics presented in previous work.
Openness to Experience Openness to Experience , Intellect , and Cognitive Ability

This article may be used for research, teaching, and private study purposes. Any substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing, systematic supply, or distribution in any form to anyone is expressly forbidden. The publisher does not give any warranty express or implied or make any representation that the contents will be complete or accurate or up to date. The accuracy of any instructions, formulae, and drug doses should be independently verified with primary sources. The publisher shall not be liable for any loss, actions, claims, proceedings, demand, or costs or damages whatsoever or howsoever caused arising directly or indirectly in connection with or arising out of the use of this material.
Food Image Recognition Using Pervasive Cloud Computing

Food image recognition is increasingly important for e-health applications. But this is a challenging topic due to the diversity of food, and color, light, view angles' effect on food image. Based on empirical and experimental explorations, we propose to use SIFT(Scale Invariant Feature Transform) and Gabor descriptors as food image features and KMeans algorithm for feature clustering. We also propose to use pervasive cloud computing paradigm to improve the performance of food image recognition due to the heavy computing requirement for large number of concurrent recognition requests. Evaluations show that the proposed approach can give acceptable recognition rate, and MapReduce programming can provide promising performance advantage compared to traditional client server approach.
An efficient approach to large-scale genotype-phenotype association analyses

Modern molecular biotechnology generates a great deal of intermediate information, such as transcriptional and metabolic products in bridging DNA and complex traits. In genome-wide linkage analysis and genome-wide association study, regression analysis for large-scale correlated phenotypes is applied to map genes for those by-products that are regarded as quantitative traits. For a single trait, least absolute shrinkage and selection operator with coordinate descent step can be employed to efficiently shrink sparse non-zero genetic effects of quantitative trait loci (QTLs). However, regression analyses in a trait-by-trait basis do not take account of the correlations among the analyzed traits. In this study, conditional phenotype of each trait is defined, given other traits. Large-scale genotype-phenotype association analyses are therefore transformed to separate genotype-conditional phenotype ones. Meanwhile, the correlation architecture between each trait and other traits can also be provided by shrinkage estimation for each conditional phenotype. Simulation demonstrates that the proposed conditional mapping method is generally identical to joint mapping method based on multivariate analysis in terms of statistical detection power and parameter estimation. Application of the method is provided to locate eQTL in yeast.
The prognostic value of multiparameter flow cytometry minimal residual disease assessment in relapsed multiple myeloma

Achieving deep levels of remission is one of the prerequisites to reach long-term survival in solid tumors and hematologic malignancies, and this has also been proved in newly diagnosed multiple myeloma (MM) patients, particularly in the era of novel agents. [1][1]–[3][2] Accordingly, both the
Methods and compositions for tissue regeneration

The present invention provides the use and composition of matter of angiogenic or other growth/cytokine factors expressed by mixtures of allogeneic human cell strains or lines of various types and stages of differentiation. Also provided are unencapsulated preparations (mixed with or applied to extracellular matrix material or synthetic biocompatible substances) for the purpose of temporary application to wounds or defects in the skin or other tissues for the restoration of blood supplying connective tissue to enable organ-specific cells to reestablish organ integrity as well as to inhibit excessive scar formation.
Analysis of Instant Search Query Logs ( Full Version )

Instant search is a new search paradigm that shows results as a user types in a query. It has become increasingly popular in recent years due to its simplicity and power. In an instant-search system, every keystroke from a user triggers a new request to the server. Therefore, its log has a richer content than that of a traditional search system, and previous log analysis research is not directly applicable to this type of log. In this paper, we study the problem of analyzing the query log of an instant-search system. We propose a classification scheme for user typing behaviors. We use the identified typing behaviors to estimate the success rate of such a system in the absence of click-through data. We also compare the log of an instant-search system and that of a traditional search system on the same data. The results show that on a people directory search system, instant search can typically save 2 seconds per search, reduce the typing effort by showing the results with fewer characters entered, and increase the success rate.
Characterisation of Fecal Soap Fatty Acids, Calcium Contents, Bacterial Community and Short-Chain Fatty Acids in Sprague Dawley Rats Fed with Different sn-2 Palmitic Triacylglycerols Diets

The structure of dietary triacylglycerols is thought to influence fatty acid and calcium absorption, as well as intestinal microbiota population of the host. In the present study, we investigated the impact of palmitic acid (PA) esterified at the sn-2 position on absorption of fatty acid and calcium and composition of intestinal microorganisms in rats fed high-fat diets containing either low sn-2 PA (12.1%), medium sn-2 PA (40.4%) or high sn-2 PA (56.3%), respectively. Fecal fatty acid profiles in the soaps were measured by gas chromatography (GC), while fecal calcium concentration was detected by ICP-MS. The fecal microbial composition was assessed using a 16S rRNA high-throughput sequencing technology and fecal short-chain fatty acids were detected by ion chromatograph. Dietary supplementation with a high sn-2 PA fat significantly reduced total fecal contents of fatty acids soap and calcium compared with the medium or low sn-2 PA fat groups. Diet supplementation with sn-2 PA fat did not change the entire profile of the gut microbiota community at phylum level and the difference at genera level also were minimal in the three treatment groups. However, high sn-2 PA fat diet could potentially improve total short-chain fatty acids content in the feces, suggesting that high dietary sn-2 PA fat might have a beneficial effect on host intestinal health.
Effects of Congestive Heart Failure on Ca2+ Handling in Skeletal Muscle During Fatigue

Skeletal muscle weakness and decreased exercise capacity are major symptoms reported by patients with congestive heart failure (CHF). Intriguingly, these skeletal muscle symptoms do not correlate with the decreased heart function. This suggests that CHF leads to maladaptive changes in skeletal muscles, and as reported most markedly in slow-twitch muscles. We used rats at 6 weeks after infarction to measure expression of key proteins involved in SR Ca2+ release and uptake in slow-twitch soleus muscles. We also measured force and myoplasmic free [Ca2+] ([Ca2+]i) in intact single fibers of soleus muscles. CHF rats showed clear signs of severe cardiac dysfunction with marked increases in heart weight and left ventricular end-diastolic pressure compared with sham operated rats (Sham). There were small, but significant, changes in the content of proteins involved in cellular Ca2+ handling in CHF muscles: slight increases in SR Ca2+ release channels (ie, the ryanodine receptors) and in SR Ca2+-ATPase. Tetanic force and [Ca2+]i were not significantly different between CHF and Sham soleus fibers under resting conditions. However, during the stimulation period there was a decrease in tetanic force without changes in [Ca2+]i in CHF fibers that was not observed in Sham fibers. The fatigue-induced changes recovered rapidly. We conclude that CHF soleus fibers fatigue more rapidly than Sham fibers because of a reversible fatigue-induced decrease in myofibrillar function.
BIST of delay faults in the logic architecture of symmetrical FPGAs

In this paper, we propose a BIST scheme for exhaustive testing all delay faults in the logic architecture of symmetrical FPGAs. This scheme is applicable in a manufacturing-oriented test (MOT) context. Our technique enables the detection of delay faults in the logic architecture and consists in chaining the logic cells in a specific way. The test of all the delay faults can be done with a reduced test sequence and does not require expensive ATE. To illustrate its feasibility, this BIST approach has been implemented in a VIRTEX FPGA from XILINX Inc.
Experimental validation of optimal load-allocation control in pace gait ladder decent motion for Multi-Locomotion Robot (MLR)

This paper presents an experimental validation of optimal load-allocation control in pace gait ladder decent motion for a Multi-Locomotion Robot (MLR). Since a closed chain is formed by the robot links and the vertical ladder, if using position control, a large change of internal stress will be generated inside the closed chain due to the unavoidable position errors between end effectors and their target rungs on the ladder. The internal stress has no contribution to equilibrate the robot load, however it influences a lot of the energy cost of joints inside the closed chain. Thus, an optimal load-allocation control is proposed for multi-contact robot motions by adjusting the internal stress using one or some important joints. Compared with the simulation results introduced in a previous work [1], in this paper, the robustness and effectiveness of the optimal load-allocation control is experimentally verified by the MLR in a predesigned pace gait ladder decent motion.
A Tale of Cities: Urban Biases in Volunteered Geographic Information

Geotagged tweets, Foursquare check-ins and other forms of volunteered geographic information (VGI) play a critical role in numerous studies and a large range of intelligent technologies. We show that three of the most commonly used sources of VGI – Twitter, Flickr, and Foursquare – are biased towards urban perspectives at the expense of rural ones. Utilizing a geostatistics-based approach, we demonstrate that, on a per capita basis, these important VGI datasets have more users, more information, and higher quality information within metropolitan areas than outside of them. VGI is a subset of user-generated content (UGC) and we discuss how our results suggest that urban biases might exist in non-geographically referenced UGC as well. Finally, because Foursquare is exclusively made up of VGI, we argue that Foursquare (and possibly other location-based social networks) has fundamentally failed to appeal to rural populations.
Comparison of Brain PrPd Distribution in Ovine BSE and Scrapie

Scrapie and bovine spongiform encephalopathy (BSE) are both prion diseases affecting ruminants, and these diseases do not share the same public health concerns. Surveillance of the BSE agent in small ruminants has been a great challenge, and the recent identification of diverse prion diseases in ruminants has led to the development of new methods for strain typing. In our study, using immunohistochemistry (IHC), we assessed the distribution of PrPd in the brains of 2 experimentally BSE-infected sheep with the ARQ/ARQ genotype. Distribution of PrPd in the brain, from the spinal cord to the frontal cortex, was remarkably similar in the 2 sheep despite different inoculation routes and incubation periods. Comparatively, overall PrPd brain distribution, evaluated by IHC, in 19 scrapie cases with the ARQ/ARQ, ARQ/VRQ, and VRQ/VRQ genotypes, in some cases showed similarities to the experimentally BSE-infected sheep. There was no exclusive neuroanatomical site with a characteristic and specific PrPd type of accumulation induced by the BSE agent. However, a detailed analysis of the topography, types, and intensity of PrPd deposits in the frontal cortex, striatum, piriform cortex, hippocampus, mesencephalon, and cerebellum allowed the BSE-affected sheep group to be distinguished from the 19 scrapie cases analyzed in our study. These results strengthen and emphasize the potential interest of PrPd brain mapping to help in identifying prion strains in small ruminants.
Rapid Rise in Transcription Factor mRNAs in Rat Brain After Electroshock‐Induced Seizures

Abstract: Recent studies have demonstrated that several transcription factor genes are rapidly activated by neuronal stimulation. For example, we have found that prolonged and repeated seizure activity produced by administration of chemical convulsants induces a rapid and transient increase in mRNA levels of four immediate early genes in rat brain. These genes, zif/268, c‐fos, c‐jun, andjun‐B, encode sequence specific DNA binding proteins thought to act as transcription regulatory factors. To ascertain whether a brief electrically induced seizure discharge of the type utilized in clinical electroconvulsive treatment is sufficient to induce a similar genomic response, we have examined the response of these mRNAs in rat brain following single and repeated electroshock‐induced seizures. After electroshock, mRNA levels of each of these genes increase within 15 min, and all except cjun return to near baseline levels within 4 h. Although this response is most prominent in granule cell neurons of the hippocampus, increases are also apparent in neocortex and pyriform cortex. The rapid mRNA response persists in animals receiving a chronic electroshock protocol similar to that used in clinical electroconvulsive therapy. Intrahippocampal infusion of the sodium channel antagonist tetrodotoxin blocks hippocampal mRNA responses without blocking seizures, indicating a role for electrical excitation in the electroshockinduced mRNA response. By contrast, pretreatment with anticonvulsants or selective NMDA antagonists, which reduce seizure intensity and block hindlimb extension, fails to alter mRNA responses, suggesting that seizure induction, rather than spread, is linked to these mRNA responses. Because electroshock induces robust, highly reproducible mRNA responses, it may be useful to study the neuronal genomic response to stimulation.
Genetic variability and persistent low back and lumbar radicular pain

Background: The aim of the present study was to provide an overview of the literature addressing the role of genetic factors and biomarkers predicting pain recovery in newly diagnosed lumbar radicular pain (LRP) patients. Methods: The search was performed in Medline OVID, Embase, PsycInfo and Web of Science (2004 to 2015). Only prospective studies of patients with LRP addressing the role of genetic factors (genetic susceptibility) and pain biomarkers (proteins in serum) were included. Two independent reviewers extracted the data and assessed methodological quality. Results: The search identified 880 citations of which 15 fulfilled the inclusion criteria. Five genetic variants; i.e., OPRM1 rs1799971 G allele, COMT rs4680 G allele, MMP1 rs1799750 2G allele, IL1α rs1800587 T allele, IL1RN rs2234677 A allele, were associated with reduced recovery of LRP. Three biomarkers; i.e., TNFα, IL6 and IFNα, were associated with persistent LRP. Conclusion: The present results indicate that several genetic factors and biomarkers may predict slow recovery in LRP. Still, there is a need for replication of the findings. A stricter use of nomenclature is also highly necessary. Trial registration: The review is registered PROSPERO 20 of November 2015. Registration number is CRD42015029125.
Synergistic Analgesia of Duloxetine and Celecoxib in the Mouse Formalin Test: A Combination Analysis

Duloxetine, a serotonin and noradrenaline reuptake inhibitor, and celecoxib, a non-steroidal anti-inflammatory drug, are commonly used analgesics for persistent pain, however with moderate gastrointestinal side effects or analgesia tolerance. One promising analgesic strategy is to give a combined prescription, allowing the maximal or equal efficacy with fewer side effects. In the current study, the efficacy and side effects of combined administration of duloxetine and celecoxib were tested in the mouse formalin pain model. The subcutaneous (s.c.) injection of formalin into the left hindpaw induced significant somatic and emotional pain evaluated by the biphasic spontaneous flinching of the injected hindpaw and interphase ultrasonic vocalizations (USVs) during the 1 h after formalin injection, respectively. Pretreatment with intraperitoneal (i.p.) injection of duloxetine or celecoxib at 1 h before formalin injection induced the dose-dependent inhibition on the second but not first phase pain responses. Combined administration of duloxetine and celecoxib showed significant analgesia for the second phase pain responses. Combination analgesia on the first phase was observed only with higher dose combination. A statistical difference between the theoretical and experimental ED50 for the second phase pain responses was observed, which indicated synergistic interaction of the two drugs. Concerning the emotional pain responses revealed with USVs, we assumed that the antinociceptive effects were almost completely derived from duloxetine, since celecoxib was ineffective when administered alone or reduced the dosage of duloxetine when given in combination. Based on the above findings, acute concomitant administration of duloxetine and celecoxib showed synergism on the somatic pain behavior but not emotional pain behaviors.
Customer Satisfaction Data Analysis Based on BP ANN

One of the most important benefits of ANN (artificial neural networks) is the free of the restrictions of the classic statistical techniques. Some literatures points to several limitations in multiple regressions that are overcome by ANN. This paper demonstrates the usefulness of ANN in customer satisfaction analysis and compares ANN and regression, based on data from a China company customer satisfaction survey. Based on the results of this study, there is sufficient evidence to suggest that the application of ANN in customer satisfaction analysis is useful in identifying existing patterns in the data, and synergies between the drivers of satisfaction. The advantages of using ANN are highlighted and the managerial implications of ANN to identify the key drivers and set priorities for improvements are demonstrated.
A Mobile Head-Mounted Display for Action Sports

We describe a highly portable head-mounted display designed for use in action sports such as skiing and snowboarding. The low field-of-view, monocular display is designed to keep distraction to a minimum and not impede the mobility of the wearer. Implications of the location of the monocular display are discussed. The driving electronics and power source are small enough so that no tethering is needed, all electronics are attached to the display.
Cell Type–Specific Regulation of Angiogenic Growth Factor Gene Expression and Induction of Angiogenesis in Nonischemic Tissue by a Constitutively Active Form of Hypoxia-Inducible Factor 1

Abstract— Understanding molecular mechanisms regulating angiogenesis may lead to novel therapies for ischemic disorders. Hypoxia-inducible factor 1 (HIF-1) activates vascular endothelial growth factor (VEGF) gene expression in hypoxic/ischemic tissue. In this study we demonstrate that exposure of primary cultures of cardiac and vascular cells to hypoxia or AdCA5, an adenovirus encoding a constitutively active form of HIF-1&agr;, modulates the expression of genes encoding the angiogenic factors angiopoietin-1 (ANGPT1), ANGPT2, placental growth factor, and platelet-derived growth factor-B. Loss-of-function effects were also observed in HIF-1&agr;–null embryonic stem cells. Depending on the cell type, expression of ANGPT1 and ANGPT2 was either activated or repressed in response to hypoxia or AdCA5. In all cases, there was complete concordance between the effects of hypoxia and AdCA5. Injection of AdCA5 into mouse eyes induced neovascularization in multiple capillary beds, including those not responsive to VEGF alone. Analysis of gene expression revealed increased expression of ANGPT1, ANGPT2, platelet-derived growth factor-B, placental growth factor, and VEGF mRNA in AdCA5-injected eyes. These results indicate that HIF-1 functions as a master regulator of angiogenesis by controlling the expression of multiple angiogenic growth factors and that adenovirus-mediated expression of a constitutively active form of HIF-1&agr; is sufficient to induce angiogenesis in nonischemic tissue of an adult animal.
STD based on Hough Transform and SDR using STD results: Experiments at NTCIR-9 SpokenDoc

In this paper, we report our experiments at NTCIR-9 IR for Spoken Documents (SpokenDoc) task. We participated both the STD and SDR subtasks of SpokenDoc. For STD subtask, we applied novel indexing method, called metric subspace indexing, previously proposed by us. One of the distinctive advantages of the method was that it could output the detection results in increasing order of distance without using any predefined threshold for the distance. The experimental results showed that the proposed method was very fast but there were rooms for improvement in the detection accuracy. For SDR subtask, two kinds of approaches were applied to both the lecture and passage level. The first approach used the conventional word-based IR methods based on the language modeling IR models. The second approach used the STD method for detecting the terms in the query from the spoken documents and then applied the IR methods using the detection as the term’s appearances. The experimental results showed that, though the performance of the STD-based method was lower than the word-based approaches in total, it could improve the performance if the query topic included the out-of-vocabulary words.
A Compact CPW-Fed Planar Pentagon Antenna for UWB Applications

In this paper, the design and analysis of a compact coplanar waveguide-fed ultra wideband pentagon antenna are presented. To achieve ultra wideband performance, two modiflcations are introduced. The flrst one is to remove a small fan angle on each side of the ground plan, and the second one is to modify the sharp of the patch in the width. The optimal dimensions can be achieved by a parametric analysis. The antenna design exhibits a very wide operating bandwidth of 16.7GHz with a return loss better than 10dB in the frequency range from 4.46GHz to 21.14GHz. The gain of the proposed antenna is 6.3dBi. This antenna conflguration will be useful for UWB indoor application as it is easy to fabricate and integrate with RF circuitry. All simulations in this work were carried out by using the electromagnetic software CST.