Miracle-dz/UniFAR-FTUs huggingface dataset:
Subjective and objective measures of visual awareness converge

Within consciousness research, the most appropriate assessment of visual awareness is matter of a controversial debate: Subjective measures rely on introspections of the observer related to perceptual experiences, whereas objective measures are based on performance of the observer to accurately detect or discriminate the stimulus in question across a series of trials. In the present study, we compared subjective and objective awareness measurements across different stimulus feature and contrast levels using a temporal two-alternative forced choice task. This task has the advantage to provide an objective psychophysical performance measurement, while minimizing biases from unconscious processing. Thresholds based on subjective ratings with the Perceptual Awareness Scale (PAS) and on performance accuracy were determined for detection (stimulus presence) and discrimination (letter case) tasks at high and low stimulus contrast. We found a comparable pattern of thresholds across tasks and contrasts for objective and subjective measurements of awareness. These findings suggest that objective performance measures based on accuracy and subjective ratings of the visual experience can provide similar information on the feature-content of a percept. The observed similarity of thresholds validates psychophysical and subjective approaches to awareness as providing converging and thus most likely veridical measures of awareness.
Missed Nursing Care, the Related Organizational Factors, and Strategies for Decreasing it from the Viewpoints of Nurses in University-Affiliated Hospitals of Birjand in 2019-2020

Background: For many reasons, some care services may be missed. This study was conducted to investigate missed care, the related factors, and solution for decreasing them. Materials and Methods: A descriptive, cross-sectional study was performed on 122 nurses. A multi-part tool was used to gather information, which included demographic information, the Missing Nursing Care and Related Organizational Factors, and Missed Nursing Care Reduction Strategies Questionnaire. Descriptive and inferential statistical tests including ANOVA, independent t-test, and the Pearson correlation were used. Results: The mean score (SD) of the Missing Nursing Care Questionnaire was 82.04 (8.50); thus, the amount of missed nursing care is very high. Additionally, the mean score (SD) of the Organizational Factors Questionnaire related to it was 30.98 (9.35). Considering the maximum score of the questionnaire (80), the role of organizational factors in the incidence of missing nursing care is relatively moderate. There was also a weak and inverse correlation between organizational factors and missed nursing care (r = −0.30, p < 0.01, df = 120). Based on the results, increasing the number of nurses and their level of knowledge has the greatest 67.21 (%) and least 34.42 (%) impact on reducing the incidence of missed nursing care. Conclusions: According to the results, the prevalence of missed nursing care was high. However, the contribution of organizational factors to it is relatively little. This suggests that from the perspective of nurses, factors other than organizational factors related to the workplace can lead to missing care.
Spatio-temporal GAMLSS modeling of the incidence of schistosomiasis in the central region of the State of Minas Gerais, Brazil

Abstract: In Brazil, millions of people live in areas with risk of schistosomiasis, a neglected chronic disease with high morbidity. The Schistosoma mansoni helminth is present in all macroregions of Brazil, including the State of Minas Gerais, one of the most endemic states. For this reason, the identification of potential foci is essential to support educational and prophylactic public policies to control this disease. This study aims to model schistosomiasis data based on spatial and temporal aspects and assess the importance of some exogenous socioeconomic variables and the presence of the main Biomphalaria species. Considering that, when working with incident cases, a discrete count variable requires an appropriate modeling, the GAMLSS modeling was chosen since it jointly considers a more appropriate distribution for the response variable due to zero inflation and spatial heteroscedasticity. Several municipalities presented high incidence values from 2010 to 2012, and a downward trend was observed until 2020. We also noticed that the distribution of incidence behaves differently in space and time. Municipalities with dams presented risk 2.25 times higher than municipalities without dams. The presence of B. glabrata was associated with the risk of schistosomiasis. On the other hand, the presence of B. straminea represented a lower risk of the disease. Thus, the control and monitoring of B. glabrata snails is essential to control and eliminate schistosomiasis; and the GAMLSS model was effective in the treatment and modeling of spatio-temporal data.
Social capital, depressive symptomatology, and frailty among older adults in the western areas of China

We aimed to explore the relationship between social capital (SC) and frailty, and the mediation role of depressive symptoms in this relationship. A cross-sectional study among 2,591 older adults aged ≥60 years old was conducted from September 2020 to May 2021. SC, depressive symptoms, and frailty were measured using the social capital scale, the 9-item patient health questionnaire, and the FRAIL scale, respectively. The mediation model was tested by Bootstrap PROCESS. After controlling for socio-demographical covariates, the SC was negatively correlated with frailty (r = -0.07, P = 0.001), and depressive symptomatology (r = -0.08, P<0.001); while the depressive symptomatology was positively correlated with frailty (r = 0.33, P<0.001). Logistic regression results showed that SC was associated with a lower risk of frailty (OR = 0.94; 95% CI: 0.92–0.97; P<0.001). Depressive symptomatology partially mediated (explained 36.4% of the total variance) the association between SC and frailty. Those findings suggest that SC may protect older adults from frailty by reducing depressive symptoms. Prevention and intervention implications were also discussed.
Primary complex motor stereotypies are associated with de novo damaging DNA coding mutations that identify KDM5B as a risk gene

Motor stereotypies are common in children with autism spectrum disorder (ASD), intellectual disability, or sensory deprivation, as well as in typically developing children (“primary” stereotypies, pCMS). The precise pathophysiological mechanism for motor stereotypies is unknown, although genetic etiologies have been suggested. In this study, we perform whole-exome DNA sequencing in 129 parent-child trios with pCMS and 853 control trios (118 cases and 750 controls after quality control). We report an increased rate of de novo predicted-damaging DNA coding variants in pCMS versus controls, identifying KDM5B as a high-confidence risk gene and estimating 184 genes conferring risk. Genes harboring de novo damaging variants in pCMS probands show significant overlap with those in Tourette syndrome, ASD, and those in ASD probands with high versus low stereotypy scores. An exploratory analysis of these pCMS gene expression patterns finds clustering within the cortex and striatum during early mid-fetal development. Exploratory gene ontology and network analyses highlight functional convergence in calcium ion transport, demethylation, cell signaling, cell cycle and development. Continued sequencing of pCMS trios will identify additional risk genes and provide greater insights into biological mechanisms of stereotypies across diagnostic boundaries.
EUS–guided therapies for primary and secondary prophylaxis in gastric varices—An updated systematic review and meta-analysis

Abstract Background and Objectives Gastric varices (GVs) are associated with a higher risk of uncontrolled bleeding and death when compared with esophageal varices. While endoscopic glue injection therapy has been traditionally used for secondary prophylaxis in GV, data regarding primary prophylaxis continue to emerge. Recently, EUS–guided therapies have been used in GV bleeding. Methods We conducted a comprehensive search of several major databases from inception to June 2022. Our primary goals were to estimate the pooled rates of treatment efficacy, GV obliteration, GV recurrence, and rebleeding with EUS-guided therapy in primary and secondary prophylaxis. Overall adverse events and technical failures were assessed. Random-effects model was used for our meta-analysis, and heterogeneity was assessed using the I2 % statistics. Results Eighteen studies with 604 patients were included. In primary prophylaxis, pooled rate of GV obliteration was 90.2% (confidence interval [CI], 81.1–95.2; I2 = 0). With combination EUS–glue and coil therapy, the rate was 95.4% (CI, 86.7%–98.5%; I2 = 0). Pooled rate of posttherapy GV bleeding was 4.9% (CI, 1.8%–12.4%; I2 = 0). In secondary prophylaxis, pooled rate of treatment efficacy was 91.9% (CI, 86.8%–95.2%; I2 = 12). With EUS-glue, EUS-coil, and combination EUS–glue and coil, the rates were 94.3% (CI, 88.9%–97.1%; I2 = 0), 95.5% (CI, 80.3%–99.1%; I2 = 0), and 88.7% (CI, 76%–95.1%; I2 = 14), respectively. Pooled rate of GV obliteration was 83.6% (CI, 71.5%–91.2%; I2 = 74). With EUS-glue, EUS-coil, and combination EUS–glue and coil, the rates were 84.6% (CI, 75.9%–90.6%; I2 = 31), 92.3% (CI, 81.1%–97.1%; I2 = 0), and 84.5% (CI, 50.8%–96.7%; I2 = 75), respectively. Pooled rates of GV rebleeding and recurrence were 18.1% (CI, 13.1%–24.3%; I2 = 16) and 20.6% (CI, 9.3%–39.5%; I2 = 66), respectively. Conclusion Our analysis shows that EUS-guided therapy for GVs is technically feasible and clinically successful in both primary and secondary prophylaxis of GV.
Cytosolic and mitochondrial translation elongation are coordinated through the molecular chaperone TRAP1 for the synthesis and import of mitochondrial proteins

A complex interplay between mRNA translation and cellular respiration has been recently unveiled, but its regulation in humans is poorly characterized in either health or disease. Cancer cells radically reshape both biosynthetic and bioenergetic pathways to sustain their aberrant growth rates. In this regard, we have shown that the molecular chaperone TRAP1 not only regulates the activity of respiratory complexes, behaving alternatively as an oncogene or a tumor suppressor, but also plays a concomitant moonlighting function in mRNA translation regulation. Herein, we identify the molecular mechanisms involved, showing that TRAP1 (1) binds both mitochondrial and cytosolic ribosomes, as well as translation elongation factors; (2) slows down translation elongation rate; and (3) favors localized translation in the proximity of mitochondria. We also provide evidence that TRAP1 is coexpressed in human tissues with the mitochondrial translational machinery, which is responsible for the synthesis of respiratory complex proteins. Altogether, our results show an unprecedented level of complexity in the regulation of cancer cell metabolism, strongly suggesting the existence of a tight feedback loop between protein synthesis and energy metabolism, based on the demonstration that a single molecular chaperone plays a role in both mitochondrial and cytosolic translation, as well as in mitochondrial respiration.
Determinants of continuous visiting behavior to Palawan, Philippines: Integrating Uncertainty Reduction Theory and Expectation Confirmation Theory

Palawan is a globally known island located in the Philippines. It has received several recognitions from a variety of international tourism organizations. The study aims to identify the factors affecting continuous visiting behavior to Palawan’s travel accommodations. The study incorporated covariance-based structural equation modeling (CB-SEM) to apply ideologies of Uncertainty Reduction Theory (URT) and Expectation Confirmation Theory (ECT). 712 valid respondents answered an online questionnaire that was distributed to several social media platforms. Structural Equation Modeling (SEM) identified that interactive uncertainty significantly influenced perceived performance compared to passive uncertainty. Both the physical environment and attitude of employees significantly produced an impact on service experience and price acceptance. However, the physical environment negatively influenced price acceptance. Meanwhile, the attitude of employees was the sole exogenous variable that influenced price acceptance. Food and beverage didn’t contribute a significant influence on service experience and price acceptance. Additionally, perceived performance and service experience contributed to positive confirmation. It was also revealed that confirmation was significant towards price acceptance, but was insignificant towards tourist satisfaction. Moreover, price acceptance significantly influenced tourist satisfaction. This study is the first comprehensive study that analyzed the visiting behavior in Palawan. Finally, integrating URT and ECT can be applied and extended, especially for analyzing the visiting behavior of different tourist destinations worldwide.
Investigating the dynamic mechanism of user willingness to actively publish travel-related Electronic Word-of-Mouth (eWOM) on tourism platforms

This study aims to uncover the dynamic mechanism of users’ willingness to actively publish Electronic word-of-Mouth (eWOM) on tourism platform. For this, a model with system dynamics and structural equation methods were constructed and validated. It was found that perceived usefulness, utilizing attitude, participatory, social identity, tourism experience, and platform agenda settings all had significant and positive effects on eWOM users’ willingness to actively publish eWOM on tourism platforms. However, perceived ease of use showed no effect. This study provides a reference paradigm for future studies on willingness to actively publish eWOM. The results bear implications for the management practices of tourism platforms operators and tourism destination operators. It also helps platform operators to develop relevant strategies for recovering the tourism industry in the post-COVID-19 era.
Is the increased ozone dosage key factor for its anti-inflammatory effect in an experimental model of mesenteric ischemia?

ABSTRACT BACKGROUND: Ischemia/reperfusion injury of the intestines is a severe surgical condition. This study aimed to reveal ozone therapy effects with relatively increased ozone dosage in a created ischemia/reperfusion injury model. METHODS: In this study, 24 albino Wistar rats were examined in three groups. Rats in the control group (CG, n=8) underwent only a laparotomy. In the sham group (SG, n=8) and ozone group (OG, n=8), the superior mesenteric artery (SMA) of the rats was occluded for 1 h. After de-occluding the SMA, the abdomen was closed, physiological saline was infused intraperitoneally in the SG, and an increased ozone/oxygen mixture dose (from 0.7 mg/kg to 1 mg/kg) was infused intraperitoneally in the OG. Small intestine samples were obtained at the 24th h for histopathological examination of intestinal mucosal injury and evaluated according to the Chiu score. In addition, Malondialdehyde and Myeloperoxidase levels were evaluated for oxidant levels, whereas, Glutathione (GSH) enzyme activity was measured to evaluate the tissue antioxidant system. RESULTS: Histopathologically, the Chiu score was the lowest in the CG. It was lower in the OG compared to the SG showing the ameliorating effect of ozone on the intestinal mucosa. Chiu score in the OG was higher compared to that in the CG, but not statistically significant. A significantly higher GSH level was observed in the OG compared to the SG, proving antioxidant activity. CONCLUSION: In this experimental model of ischemia/reperfusion in rats, treatment with an increased ozone level decreased the inflammatory process through antioxidant mechanisms and reduced intestinal mucosal damage. However, the effectiveness of ozone therapy depends on its dosages.
Drosha-dependent microRNAs modulate FUS-mediated neurodegeneration in vivo

Abstract Mutations in the Fused in Sarcoma (FUS) gene cause the familial and progressive form of amyotrophic lateral sclerosis (ALS). FUS is a nuclear RNA-binding protein involved in RNA processing and the biogenesis of a specific set of microRNAs. Here we report that Drosha and two previously uncharacterized Drosha-dependent miRNAs are strong modulators of FUS expression and prevent the cytoplasmic segregation of insoluble mutant FUS in vivo. We demonstrate that depletion of Drosha mitigates FUS-mediated degeneration, survival and motor defects in Drosophila. Mutant FUS strongly interacts with Drosha and causes its cytoplasmic mis-localization into the insoluble FUS inclusions. Reduction in Drosha levels increases the solubility of mutant FUS. Interestingly, we found two Drosha dependent microRNAs, miR-378i and miR-6832–5p, which differentially regulate the expression, solubility and cytoplasmic aggregation of mutant FUS in iPSC neurons and mammalian cells. More importantly, we report different modes of action of these miRNAs against mutant FUS. Whereas miR-378i may regulate mutant FUS inclusions by preventing G3BP-mediated stress granule formation, miR-6832–5p may affect FUS expression via other proteins or pathways. Overall, our research reveals a possible association between ALS-linked FUS mutations and the Drosha-dependent miRNA regulatory circuit, as well as a useful perspective on potential ALS treatment via microRNAs.
Examining the effects of prenatal alcohol exposure on performance of the sustained attention to response task in children with an FASD

Prenatal alcohol exposure (PAE), the leading known cause of childhood developmental disability, has long‐lasting effects extending throughout the lifespan. It is well documented that children prenatally exposed to alcohol have difficulties inhibiting behavior and sustaining attention. Thus, the Sustained Attention to Response Task (SART), a Go/No‐go paradigm, is especially well suited to assess the behavioral and neural functioning characteristics of children with PAE. In this study, we utilized neuropsychological assessment, parent/guardian questionnaires, and magnetoencephalography during SART random and fixed orders to assess characteristics of children 8–12 years old prenatally exposed to alcohol compared to typically developing children. Compared to neurotypical control children, children with a Fetal Alcohol Spectrum Disorder (FASD) diagnosis had significantly decreased performance on neuropsychological measures, had deficiencies in task‐based performance, were rated as having increased Attention‐Deficit/Hyperactivity Disorder (ADHD) behaviors and as having lower cognitive functioning by their caretakers, and had decreased peak amplitudes in Broadmann's Area 44 (BA44) during SART. Further, MEG peak amplitude in BA44 was found to be significantly associated with neuropsychological test results, parent/guardian questionnaires, and task‐based performance such that decreased amplitude was associated with poorer performance. In exploratory analyses, we also found significant correlations between total cortical volume and MEG peak amplitude indicating that the reduced amplitude is likely related in part to reduced overall brain volume often reported in children with PAE. These findings show that children 8–12 years old with an FASD diagnosis have decreased amplitudes in BA44 during SART random order, and that these deficits are associated with multiple behavioral measures.
Theoretical free-oscillation spectra: the importance of wide band coupling

SUMMARY Illustrative calculations are presented of the effect of the coupling of large groups of Earth's normal modes in a realistic 3-D earth model. In previous work the effect of modal splitting and coupling has been treated either in the self-coupling approximation (SC) or in the group-coupling approximation (GC), also known as quasi-degenerate perturbation theory. In SC a mode is treated as isolated in the spectrum and the theory of degenerate splitting is used to calculate the effect of lateral heterogeneity, rotation and ellipticity on each individual modal multiplet. In GC a small number of modes close together in frequency are treated as a group and the effect of coupling within the group is included. Of course, SC can be considered as a special case of GC in which there is only a single modal multiplet in the group. In principle, modal spectra are affected by coupling among all modes. Given that explicit calculations can be performed only for a finite collection of modes, we are led to consider the question of how large the group of modes considered must be in order to obtain theoretical spectra of sufficient accuracy for a given purpose. The particular purpose that we have in mind is the use of modal spectra to refine 3-D models of earth structure. To do this we carry out calculations in which the results of SC and GC are compared with those of full coupling (FC), by which we mean coupling calculations including large collections of multiplets, for example all modes having frequencies less than a certain upper bound or cut-off frequency. The results indicate that SC and GC often represent a poor approximation to FC. The differences in modal spectra calculated using SC/GC and those obtained using FC are, in many cases, comparable to the differences between observed and theoretical spectra. We compare FC for all 140 spheroidal and toroidal modes up to 3 mHz with GC using the 25 pairs of modes defined by Resovsky & Ritzwoller (1998) and with GC in 33 subgroups of spheroidal and toroidal modes. We find that full coupling is needed to obtain the best synthetic spectra. The matrices for full coupling of 140 modes become large (approximately 2500×2500), but are still tractable.
Archaeofacies analysis: Using depositional attributes to identify anthropic processes of deposition in a monumental shell mound of Santa Catarina State, southern Brazil

In the coast of Santa Catarina State (southern Brazil), a large population of monumental shell mounds characterizes a highly dynamic coastal setting. In this paper, sedimentary facies analysis was adapted for description, sampling, and interpretation of shell mound complex and repetitive archaeostratigraphic successions. Archaeofacies identification in the field, according to depositional attributes, is tested by contrasting field description with multi‐element chemical analyses, total carbon and nitrogen determinations, and micromorphological descriptions. Two vertical sequences at the black deposit of Jabuticabeira II shell mound were studied and preliminary results showed that: (1) depositional attributes are a reliable base for archaeofacies identification in the field, (2) the formation process of this site involved a sequence of anthropic depositional processes, where burned refuse was redeposited over the shell mound following a ritual construction pattern, and (3) the black deposit includes a double palimpsest that refers to provenance and meaning of mound construction material. © 2009 Wiley Periodicals, Inc.