Miracle-dz/UniFAR-FTUs huggingface dataset:
Home monitoring after ambulatory implanted primary cardiac implantable electronic devices: The home ambulance pilot study

The Home Monitoring (HM) system of cardiac implantable electronic devices (CIEDs) permits early detection of arrhythmias or device system failures. The aim of this pilot study was to examine how the safety and efficacy of the HM system in patients after ambulatory implanted primary CIEDs compare to patients with a standard procedure and hospitalization.
Coulomb friction effects on the dynamics of bearings and transmissions in precision robot mechanisms

General guidelines for analyzing friction at the joints are discussed. It is shown that friction can be related to the joint coordinates and their first and second time derivatives. The resulting extended robot dynamics formulation is investigated as it applies to the inverse and forward robot dynamics problems. The analytical dependency of Coulomb friction on joint interactions is explicitly examined. As an illustration of friction effects in transmissions, the friction in harmonic drives is considered and a method is developed for its evaluation. The quantitative characterization of several specific cases is provided. The study is significant for the design and control achieving of high-speed precision robot motion. <<ETX>>
The Molecular Chaperone Hsp90 Modulates Intermediate Steps of Amyloid Assembly of the Parkinson-related Protein α-Synuclein*

α-Synuclein is an intrinsically unstructured protein that binds to membranes, forms fibrils, and is involved in neurodegeneration. We used a reconstituted in vitro system to show that the molecular chaperone Hsp90 influenced α-synuclein vesicle binding and amyloid fibril formation, two processes that are tightly coupled to α-synuclein folding. Binding of Hsp90 to monomeric α-synuclein occurred in the low micromolar range, involving regions of α-synuclein that are critical for vesicle binding and amyloidogenesis. As a consequence, both processes were affected. In the absence of ATP, the accumulation of non-amyloid α-synuclein oligomers prevailed over fibril formation, whereas ATP favored fibril growth. This suggests that Hsp90 modulates the assembly of α-synuclein in an ATP-dependent manner. We propose that Hsp90 affects these folding processes by restricting conformational fluctuations of α-synuclein.
How is the spread of the Electric Vehicles?

Many automotive manufacturers are investing heavily in Electric Vehicle (EV) design and manufacturing. Governments and other public sector bodies are making significant investments in the development of EVs and introducing various tax credits, incentives and subsidies. In addition, energy companies and other industries have set their sights on electric vehicles. In particular, EV development is being strongly fueled by consumer demand stemming from economic and environmental factors. The scope of this work is to present a representation of the spread of EVs in some European countries, in order to address an integration of green energy with recharge of EVs with particular attention for Italy. The States concerned are United Kingdom, Germany, France, the Netherlands and Norway, Italy. Each state has its policy for incentives, divided in assistance in purchasing and benefits in use. It was described policy incentives held in recent years and the results were reported suggesting to implement a policy of incentives, for purchase and use.
A Tool to Develop Arabic Handwriting Recognition System Using Genetic Approach

Problem statement: Significant movement has been made in handwriting recognition technology over the last few years. Up until now, Arabic handwriting recognition systems have been limited to small and medium vocabulary applications, since most of them often rely on a database during the recognition process. The facility of dealing with large database, however, opens up many more applications. Approach: This study presented a complete system to recognize off-line Arabic handwriting image and Arabic handwriting and printed text database AHPD-UTM that used to implement and test the system. That system start from preprocessing and segmentation phases that deepened on thinning the image and found the V and H projection profile until recognition phase by genetic algorithm. Results: The genetic algorithm stand on feature extraction algorithm that defined six feature for each segment beak. The system can be recognized Arabic handwriting with 87% accuracy. The confusion and rejection rates are 8.4, those causes for several problems like characters with broken loops and character segmentation problem. Conclusion: Peak connection solved some of the segmentation problems and helped to provide better accuracy.
Identification of an antigen common to different species of the genus Campylobacter

Affinity-purified antibody specific for a determinant on flagellin from Campylobacter jejuni was used to screen by immunoblotting strains of C. coli, C. laridis, C. fetus, "C. upsaliensis," C. pylori, and C. sputorum biovar fecalis. The antigen was detected in each of these species, but the molecular weights of the proteins bearing the common antigen varied considerably.
Structural studies of RFCCtf 18 reveal a novel chromatin recruitment role for Dcc 1

Replication factor C complexes load and unload processivity clamps from DNA and are involved in multiple DNA replication and repair pathways. The RFC variant complex is required for activation of the intra-S-phase checkpoint at stalled replication forks and aids the establishment of sister chromatid cohesion. Unlike other RFC complexes, RFC contains two non-Rfc subunits, Dcc1 and Ctf8. Here, we present the crystal structure of the Dcc1-Ctf8 heterodimer bound to the C-terminus of Ctf18. We find that the C-terminus of Dcc1 contains three-winged helix domains, which bind to both ssDNA and dsDNA. We further show that these domains are required for full recruitment of the complex to chromatin, and correct activation of the replication checkpoint. These findings provide the first structural data on a eukaryotic seven-subunit clamp loader and define a new biochemical activity for Dcc1.
Thromboembolic Events Lead to Cortical Spreading Depression and Expression of c-fos, Brain-Derived Neurotrophic Factor, Glial Fibrillary Acidic Protein, and Heat Shock Protein 70 mRNA in Rats

The hypotheses that cerebral embolic events lead to repetitive episodes of cortical spreading depression (CSD) and that these propagating waves trigger the expression of c-fos, brain-derived neurotrophic factor (BDNF), glial fibrillary acidic protein (GFAP), and heat shock protein 70 (HSP70) mRNA were tested. Wistar rats underwent photochemically induced right common carotid artery thrombosis (CCAT) (n = 18) or sham (n = 8) procedures. In a subgroup of rats (n = 5), laser-Doppler flowmetry probes were placed overlying the right parietal cortex to record CSD-like changes in cortical blood flow during the initial 2-hour postinjury period. Rats were killed by decapitation at 2 or 24 hours after CCAT, and brains were processed for in situ localization of the gene expression. Two to five intermittent transient hyperemic episodes lasting 1 to 2 minutes were recorded ipsilaterally after CCAT. At 2 hours after CCAT, the widespread expression of c-fos and BDNF mRNAs was observed throughout the ipsilateral cerebral cortex. Pretreatment with the N-methyl-d-aspartate receptor blocker MK-801 (2 mg/kg) 1 hour before CCAT reduced the expression of BDNF mRNA expression at 2 hours. At 24 hours after CCAT, increased expression of GFAP mRNA was present in cortical and subcortical regions. In contrast, multifocal regions of HSP70 expression scattered throughout the thrombosed hemisphere were apparent at both 2 and 24 hours after injury. These data indicate that thromboembolic events lead to episodes of CSD and time-dependent alterations in gene expression. The ability of embolic processes to induce widespread molecular responses in neurons and glia may be important in the pathogenesis of transient ischemic attacks and may influence the susceptibility of the postembolic brain to subsequent insults including stroke.
Translating Erlang to /spl mu/CRL

The language Erlang has been developed by Ericsson to implement large switching systems. Erlang is nowadays used by several companies for complex embedded systems. The language /spl mu/CRL is a process algebra with data. Several verification tools are available for /spl mu/CRL and other process algebras, including a tool to create labelled transition systems from /spl mu/CRL specifications. By having a translation from Erlang to /spl mu/CRL we can apply the verification tools for process algebras and labelled transition systems to industrial code. The translation is aware of the major design component in the switching software. This knowledge is used to ensure that the size of the labelled transition system generated by the tools is smaller than with a naive translation.
Toward One Class Classifier techniques applied to verifier information

One Class Classifier techniques have the ability to identify data that is unknown with respect to a group of known observations. However, the training set only contains instances of the known class and no instances at all or very few instances of unknown data. During training, in the verify problem of a wrapper, we only have instances of the classes we know. Therefore, the One Class Classifier techniques could be applied. In order to evaluate the performance of these methods we use different databases proposed in the current literature. Statistical analyses of the results obtained by some basic One Class Classification techniques like parzen_dd, gauss_dd, svmdd, som_dd and knndd will be described.
Dynamic Rheology and Microstructure of Polypropylene/Clay Nanocomposites Prepared Under Sc-CO2 by Melt Compounding

The polypropylene (PP)/clay nanocomposites were prepared using a twin screw extruder with the aid of the supercritical carbon dioxide (Sc-CO2 ). The dynamic rheological properties were measured using a rheometer in the oscillatory mode. X-ray diffraction and transmission electron microscopy were used to characterize the microstructure of extruded nanocomposites. Results showed that an optimized CO2 concentration existed. When the CO2 concentration increased up to the optimized level, the nanocomposites tended to be more viscous, especially at low frequency. Whereas further increasing the CO2 concentration resulted in the decrease in the complex viscosity and dynamic moduli. The presence of Sc-CO2 with the concentration not higher than the optimized level was helpful to promote the degree of dispersion of the nano-clay in PP matrix, and overloaded CO2 would have negative effect on the clay dispersion.Copyright © 2007 by ASME
Suffix Tree Clustering with Named Entity Recognition

The news searching is challengeable in providing web users with clear and readable lists of news reports. This paper proposes the Suffix Tree Clustering with Named Entity Recognition (STC-NER). STC-NER is supposed to cluster news searching results returned by the search engine. STC-NER uses the snippets returned from the searching results and then derives patterned information by means of named entity recognition. STC-NER makes a great contribute to the reduction of storage as well as the time complexity. Experiments show that STC-NER has a better performance in precision and efficiency than the traditional Suffix Tree Clustering (STC).
Complete Genome and Phylogeny of Puumala Hantavirus Isolates Circulating in France

Puumala virus (PUUV) is the agent of nephropathia epidemica (NE), a mild form of hemorrhagic fever with renal syndrome (HFRS) in Europe. NE incidence presents a high spatial variation throughout France, while the geographical distribution of the wild reservoir of PUUV, the bank vole, is rather continuous. A missing piece of the puzzle is the current distribution and the genetic variation of PUUV in France, which has been overlooked until now and remains poorly understood. During a population survey, from 2008 to 2011, bank voles were trapped in eight different forests of France located in areas known to be endemic for NE or in area from where no NE case has been reported until now. Bank voles were tested for immunoglobulin (Ig)G ELISA serology and two seropositive animals for each of three different areas (Ardennes, Jura and Orleans) were then subjected to laboratory analyses in order to sequence the whole S, M and L segments of PUUV. Phylogenetic analyses revealed that French PUUV isolates globally belong to the central European (CE) lineage although isolates from Ardennes are clearly distinct from those in Jura and Orleans, suggesting a different evolutionary history and origin of PUUV introduction in France. Sequence analyses revealed specific amino acid signatures along the N protein, including in PUUV from the Orleans region from where NE in humans has never been reported. The relevance of these mutations in term of pathophysiology is discussed.
Novel Chitin and Chitosan Materials in Wound Dressing

R. Jayakumar1, M. Prabaharan2, P. T. Sudheesh Kumar1, S. V. Nair1, T. Furuike3 and H. Tamura3 1Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidhyapeetham University, 2Department of Chemistry, Faculty of Engineering and Technology, SRM University, 3Faculty of Chemistry, Materials and Bioengineering, Kansai University, 1,2India 3Japan
Differences in Acinetobacter baumannii Strains and Host Innate Immune Response Determine Morbidity and Mortality in Experimental Pneumonia

Despite many reports documenting its epidemicity, little is known on the interaction of Acinetobacter baumannii with its host. To deepen our insight into this relationship, we studied persistence of and host response to different A. baumannii strains including representatives of the European (EU) clones I–III in a mouse pneumonia model. Neutropenic mice were inoculated intratracheally with five A. baumannii strains and an A. junii strain and at several days morbidity, mortality, bacterial counts, airway inflammation, and chemo- and cytokine production in lungs and blood were determined. A. baumannii RUH875 and RUH134 (EU clone I and II, respectively) and sporadic strain LUH8326 resulted in high morbidity/mortality, whereas A. baumannii LUH5875 (EU clone III, which is less widespread than clone I and II) caused less symptoms. A. baumannii type strain RUH3023T and A. junii LUH5851 did not cause disease. All strains, except A. baumannii RUH3023T and A. junii LUH5851, survived and multiplied in the lungs for several days. Morbidity and mortality were associated with the severity of lung pathology and a specific immune response characterized by low levels of anti-inflammatory (IL-10) and specific pro-inflammatory (IL-12p40 and IL-23) cytokines at the first day of infection. Altogether, a striking difference in behaviour among the A. baumannii strains was observed with the clone I and II strains being most virulent, whereas the A. baumannii type strain, which is frequently used in virulence studies appeared harmless.
Enhancing User Privacy on Android Mobile Devices via Permissions Removal

Android mobile devices are becoming a popular alternative to computers. The rise in the number of tasks performed on smartphones means sensitive information is stored on the devices. Consequently, Android devices are a potential vector for criminal exploitation. Existing research on enhancing user privacy on Android devices can generally be classified as Android modifications. These solutions often require operating system modifications, which significantly reduce their potential. This research proposes the use of permissions removal, wherein a reverse engineering process is used to remove an app's permission to a resource. The repackaged app will run on all devices the original app supported. Our findings that are based on a study of seven popular social networking apps for Android mobile devices indicate that the difficulty of permissions removal may vary between types of permissions and how well-integrated a permission is within an app.
Expression of two synapse-enriched glycoproteins, gp65 and gp55, during rat brain development

479-492 and 1 : 100 against GABA, receptor purified from adult bovine'cerebral cortex. The titre is defined as that dilution of serum which would produce an absorbance equal to half of the maximum response. The immune response against purified GABA, receptor, measured by ELISA was blocked by preincubating the serum with the free Cys-a3 479-492 peptide (Fig. la) . A Western blot of purified GABA, from adult bovine cerebral cortex is shown in Fig. 1( b). Antisera raised against Cys-a3 479-492 reacted with a polypeptide with M , 59 000-60 000. This is in contrast with the antiserum raised against the a 1 isoform-specific peptide, a 1 1-1 5, which reacted predominantly with a polypeptide of M , 53 000. Both a 1 and a 3 immunoreactivity were found in GABA, receptor preparations purified from adult bovine cerebral cortex, cerebellum, hippocampus and 12-day-old calf cerebral cortex (Stephenson et al. (1989)). Thus, we have demonstrated the presence of a polypeptide which was predicted from the identification of a cDNA which encodes the a3 subunit. This polypeptide has M , 59 000-60 000 compared with a molecular mass of 52 000 Da calculated from the deduced primary structure; the difference is attributed to N-glycosylation (Levitan et al., 1988). The a 3 subunit was not found previously because in one-dimensional SDS/PAGE it comigrates with the Psubunit ( M , 57 000-58 000). Kirkness & Turner (1988) have recently shown that the P-band can be resolved using antibodies which can be predicted to recognize all three a subunit isoforms. In several species, photoaffinity labelling of the GABA, receptor with the benzodiazepine, [ 3H]flunitrazepam has shown that bands other than the a-subunit incorporated radiolabel (reviewed in Stephenson, 1988). The discovery of isoforms of the a-subunit with different M , may explain these results. The isoform-specific antibodies described here may serve as important tools in the elucidation of their functional importance.
Discrete event simulation of emergency department activity: a platform for system-level operations research.

OBJECTIVES This article explores the potential of discrete event simulation (DES) methods to advance system-level investigation of emergency department (ED) operations. To this end, the authors describe the development and operation of Emergency Department SIMulation (EDSIM), a new platform for computer simulation of ED activity at a Level 1 trauma center. The authors also demonstrate one potential application of EDSIM by using simulated ED activity to compare two patient triage methods. METHODS The Extend DES modeling package was used to develop a model of ED activity for a five-day period in July 2003. Model input includes staffing levels, facility characteristics, and patient data drawn from electronic patient tracking databases, billing records, and a detailed review of 674 ED charts. The accuracy of model output was tested by comparing predicted and known patient service times. The EDSIM model was then used to compare the fast-track triage approach with an alternative acuity ratio triage (ART) approach whereby patients were assigned to staff on an acuity ratio basis. RESULTS The EDSIM model predicts average patient service times within 10% of actual values. The accuracy of individual patient paths, however, was variable. In the authors' model, 28% of individual patient treatment times had an absolute error of less than one hour, and 59% less than three hours. A preliminary comparison of two triage methods showed that the ART approach reduced imaging bottlenecks and average treatment times for high-acuity patients, but resulted in an overall increase in average service time for low-acuity patients. CONCLUSIONS The EDSIM model provides a flexible platform for studying ED operations as they relate to average treatment times for ED patients, but the model will require further refinement to predict individual patient times. A comparative study of triage methods suggests that ART provides a mix of benefits and drawbacks, but further investigation will be required to substantiate these preliminary findings.
Prognostic Significance of CT-Determined Sarcopenia in Patients with Small-Cell Lung Cancer

Introduction: The primary objective of this study was to determine the prognostic significance of computed tomography (CT)-determined sarcopenia in small-cell lung cancer (SCLC) patients. Methods: This retrospective study consisted of a total of 149 consecutive SCLC patients. The cross-sectional area of muscle at the level of the third lumbar vertebra (L3) was measured using baseline CT images. Sarcopenia was defined as a L3 muscle index of less than 55 cm2/m2 for men and of less than 39 cm2/m2 for women as proposed by international consensus of cancer cachexia. In addition, Korean-specific cutoffs for sarcopenia was also applied (49 cm2/m2 for men and 31 cm2/m2 for women). Overall survival (OS) and clinical characteristics of patients with or without sarcopenia were compared. Results: Mean patient age was 68.6 ± 9.5 years. Most were male (85.3%) and 67.8% had extensive disease at time of diagnosis. Sarcopenia was present in 118 patients (79.2%) and was significantly related to an advanced age (p = 0.028), male sex (p < 0.001), lower body mass index (p < 0.001), and poor performance status (p = 0.049). Sarcopenic patients had shorter OS than nonsarcopenic patients (median: 8.6 months versus 16.8 months; p = 0.031). Multivariable analysis revealed that sarcopenia was an independent prognostic factor of poor survival (hazards ratio: 1.68; 95% confidence interval: 1.04–2.72; p = 0.034), along with extensive stage (p < 0.001), supportive care only (p < 0.001), and an elevated lactate dehydrogenase level (p = 0.020). Using Korean sarcopenia cutoffs, sarcopenic patients were also found to have poorer OS than nonsarcopenic patients, however, the survival difference was not statistically significant (median: 8.4 months versus 12.7 months; p = 0.144 by the log-rank test). Conclusions: Sarcopenia as determined by CT could be used to predict prognosis in patients with SCLC. Optimum reference values to predict cancer-specific outcomes should be tailored by further studies.