Miracle-dz/UniFAR-FTUs huggingface dataset:
Treatment of multiple sclerosis with the pregnancy hormone estriol

Multiple sclerosis patients who become pregnant experience a significant decrease in relapses that may be mediated by a shift in immune responses from T helper 1 to T helper 2. Animal models of multiple sclerosis have shown that the pregnancy hormone, estriol, can ameliorate disease and can cause an immune shift. We treated nonpregnant female multiple sclerosis patients with the pregnancy hormone estriol in an attempt to recapitulate the beneficial effect of pregnancy. As compared with pretreatment baseline, relapsing remitting patients treated with oral estriol (8mg/day) demonstrated significant decreases in delayed type hypersensitivity responses to tetanus, interferon‐γ levels in peripheral blood mononuclear cells, and gadolinium enhancing lesion numbers and volumes on monthly cerebral magnetic resonance images. When estriol treatment was stopped, enhancing lesions increased to pretreatment levels. When estriol treatment was reinstituted, enhancing lesions again were significantly decreased. Based on these results, a larger, placebo‐controlled trial of estriol is warranted in women with relapsing remitting multiple sclerosis. This novel treatment strategy of using pregnancy doses of estriol in multiple sclerosis has relevance to other autoimmune diseases that also improve during pregnancy.
Redundant phenazine operons in Pseudomonas aeruginosa exhibit environment-dependent expression and differential roles in pathogenicity

Evolutionary biologists have postulated that several fitness advantages may be conferred by the maintenance of duplicate genes, including environmental adaptation resulting from differential regulation. We examined the expression and physiological contributions of two redundant operons in the adaptable bacterium Pseudomonas aeruginosa PA14. These operons, phzA1-G1 (phz1) and phzA2-G2 (phz2), encode nearly identical sets of proteins that catalyze the synthesis of phenazine-1-carboxylic acid, the precursor for several phenazine derivatives. Phenazines perform diverse roles in P. aeruginosa physiology and act as virulence factors during opportunistic infections of plant and animal hosts. Although reports have indicated that phz1 is regulated by the Pseudomonas quinolone signal, factors controlling phz2 expression have not been identified, and the relative contributions of these redundant operons to phenazine biosynthesis have not been evaluated. We found that in liquid cultures, phz1 was expressed at higher levels than phz2, although phz2 showed a greater contribution to phenazine production. In colony biofilms, phz2 was expressed at high levels, whereas phz1 expression was not detectable, and phz2 was responsible for virtually all phenazine production. Analysis of mutants defective in quinolone signal synthesis revealed a critical role for 4-hydroxy-2-heptylquinoline in phz2 induction. Finally, deletion of phz2, but not of phz1, decreased lung colonization in a murine model of infection. These results suggest that differential regulation of the redundant phz operons allows P. aeruginosa to adapt to diverse environments.
Upscaling of soil hydraulic properties for steady state evaporation and infiltration

Estimation of effective/average soil hydraulic properties for large land areas is an outstanding issue in hydrologic modeling. The goal of this study is to provide flow‐specific rules and guidelines for upscaling soil hydraulic properties in an areally heterogeneous field. In this study, we examined the impact of areal heterogeneity of soil hydraulic parameters on soil ensemble behavior for steady state evaporation and infiltration. The specific objectives of this study are (1) to address the impact of averaging methods of shape parameters and parameter correlation on ensemble behavior of steady state flow in an areally heterogeneous field and (2) to investigate the effectiveness of the “average parameters” in terms of the degree of correlation between hydraulic property parameters for the steady state evaporation and infiltration in unsaturated soil. Using an analytical solution of Richards' equation, the ensemble characteristics and flow dynamics based on average hydraulic property parameters are studied for evaporation and infiltration. Using various flow and average scenarios, we illustrated the resulting differences among the various averaging schemes. For vertical evaporation and infiltration the use of a geometric mean value for the shape parameter α of Gardner‐Russo model and Brooks‐Corey model and arithmetic mean value for the saturated hydraulic conductivity Ks simulates the ensemble flow behavior the best. The efficacy of the “average parameters” depends on the flow condition and the degree of correlation between the hydraulic property parameters. With the α and Ks parameters perfectly correlated, the “average parameters” were found to be generally most effective. The correlation between the hydraulic conductivity Ks and the parameter α results in an ensemble soil behavior more like a sand.
Shape-Controlled Synthesis of Au Nanostructures Using EDTA Tetrasodium Salt and Their Photothermal Therapy Applications

Tuning the optical properties of Au nanostructures is of paramount importance for scientific interest and has a wide variety of applications. Since the surface plasmon resonance properties of Au nanostructures can be readily adjusted by changing their shape, many approaches for preparing Au nanostructures with various shapes have been reported to date. However, complicated steps or the addition of several reagents would be required to achieve shape control of Au nanostructures. The present work describes a facile and effective shape-controlled synthesis of Au nanostructures and their photothermal therapy applications. The preparation procedure involved the reaction of HAuCl4 and ethylenediaminetetraacetic acid (EDTA) tetrasodium salt, which acted as a reducing agent and ligand, at room temperature without the need for any toxic reagent or additives. The morphology control from spheres to branched forms and nanowire networks was easily achieved by varying the EDTA concentration. Detailed investigations revealed that the four carboxylic groups of the EDTA tetrasodium salt are essential for effective growth and stabilization. The produced Au nanowire networks exhibited a broad absorption band in the near-infrared (NIR) region, thereby showing efficient cancer therapeutic performance by inducing the selective photothermal destruction of cancerous glioblastoma cells (U87MG) under NIR irradiation.
Addition of deep brain stimulation signal to a local field potential driven Izhikevich model masks the pathological firing pattern of an STN neuron

The crucial engagement of the subthalamic nucleus (STN) with the neurosurgical procedure of deep brain stimulation (DBS) that alleviates medically intractable Parkinsonian tremor augments the need to refine our current understanding of STN. To enhance the efficacy of DBS as a result of precise targeting, STN boundaries are accurately mapped using extracellular microelectrode recordings (MERs). We utilized the intranuclear MER to acquire the local field potential (LFP) and drive an Izhikevich model of an STN neuron. Using the model as the test bed for clinically acquired data, we demonstrated that stimulation of the STN neuron produces excitatory responses that tonically increase its average firing rate and alter the pattern of its neuronal activity. We also found that the spiking rhythm increases linearly with the increase of amplitude, frequency, and duration of the DBS pulse, inside the clinical range. Our results are in agreement with the current hypothesis that DBS increases the firing rate of STN and masks its pathological bursting firing pattern.
The cut-off analysis using visual analogue scale and cepstral assessments on severity of voice disorder

Abstract Purpose: The aims of this study were to: (1) determine the visual analogue scale (VAS) and cepstrum peak prominence (CPP) cut-off points on the ratings of numerical scale (NS) related to the severity of voice disorder ratings and (2) verify the discriminative power of these cut-off points for distinguishing between different severities of voice disorder. Methods: Auditory-perceptual severity assessments (VAS and four-point NS) of 214 voice samples were performed by three speech-language pathologists and CPP parameters were used for the acoustic analysis. Both VAS and CPP cut-off points were obtained using receiver operating characteristic (ROC) curve analyses, based on their correspondence with NS ratings. Results: A high level of inter- and intra-rater reliability was found for the auditory-perceptual assessments of both VAS and NS. The VAS cut-off points for overall severity (OS), between normal variation and mild/moderate severity, mild/moderate and moderate severity, and moderate and severe severity were 32.7, 51.7, and 71.7 points, respectively, and CPP cut-off points were 7.050, 4.651, and 2.989 points, respectively. Areas under the ROC curves demonstrated excellent specificity and sensitivity of all cut-off points. Conclusions: The VAS and CPP cut-off points of OS of voice disorder demonstrated a high power to discriminate between different severities of voice disorder. The results of this study suggested cut-off points for clinical use.
Bayesian hierarchical distributed lag models for summer ozone exposure and cardio‐respiratory mortality

In this article we develop Bayesian hierarchical distributed lag models for estimating associations between daily variations in summer ozone levels and daily variations in cardiovascular and respiratory (CVDRESP) mortality counts for 19 large U.S. cities included in the National Morbidity, Mortality and Air Pollution Study (NMMAPS) for the summers of 1987–1994.
Journal of Graph Algorithms and Applications Lombardi Drawings of Graphs

We introduce the notion of Lombardi graph drawings, named after the American abstract artist Mark Lombardi. In these drawings, edges are represented as circular arcs rather than as line segments or polylines, and the vertices have perfect angular resolution: the edges are equiangularly spaced around each vertex. We describe algorithms for finding Lombardi drawings of regular graphs, graphs of bounded degeneracy, and certain families of planar graphs.
Identification, sexual dimorphism, and allometric effects of three psyllid species of the genus Psyllopsis by geometric morphometric analysis (Hemiptera, Liviidae)

Abstract Jumping plant lice (Hemiptera: Psylloidea) are considered important vectors of plant diseases and also economically important pests in agriculture and forest ecosystems. Three psyllid species Psyllopsis repens Loginova, 1963, Psyllopsis securicola Loginova, 1963, and Psyllopsis machinosus Loginova, 1963 associated with the ash tree Fraxinus are morphologically very similar. So far, their distinction has been possible only by comparing their male and female genitalia. In this research, forewing shape and size characteristics, sexual dimorphism and their allometric effects, using geometric morphometric analysis, were examined for identification purposes. The results showed significant differences in wing shape and size between the species studied. Based on the results, two species P. machinosus and P. securicola can be differentiated with the vein M1+2, as in P. securicola the vein M1+2 is located between Rs and M3+4 veins, but the vein M1+2 is closer to the vein M3+4 in P. machinosus; also, P. repens can be differentiated from the two species P. machinosus and P. securicola by vein M. Hence, the veins M1+2, M3+4, Rs and M were the most important wing characters for discrimination of the three species, especially in the field. The analysis also showed significant differences in wing shape and size between male and female of the three species, and the allometric analysis showed that significant shape differences still remain in constant size in P. machinosus and P. repens. Geometric changes in the forewings of both sexes for the three species are illustrated.
Optimal monopulse tracking of signal source of unknown amplitude

Estimation of the direction of arrival of a signal source by means of a monopulse antenna is one of the oldest and most widely used high resolution techniques [1]. Although the statistical performance of this estimation technique has been extensively investigated for decades, recent work [2] based on an analysis of the problem from the point of view of optimal detection applied to a two-sensors system, has shown that the common solution (detector/estimator) restricts the accessible performance. Indeed, changing the detector is necessary to optimize the overall performance. First derived in the particular case of Rayleigh-type signal source, this approach can be extended to the case of a signal source of unknown amplitude (including the non fluctuating case). The present paper establishes analytical performance of both new and common solutions in that case.
Disrupted network interactions in chronic cocaine dependents as revealed by modular network analysis of resting-state functional MRI

Background: Drug addiction is a neuropsychiatrc disorder characterized as compulsive drive to take the drug even at the expense of serious adverse consequences. Functional neuroimaging studies on chronic cocaine dependents revealed their impairments in various brain circuits [1], including the midbrain dopaminergic areas and their projection to the striatum (ST) regions involved in reward [2,3,4], the hippocampus and amygdala regions in medial temporal lobe (MTL) implicated in memory and emotion [2], and the executive control network (ECN) related primarily to external cognitive function [5]. In addition, two other brain networks, the default mode network (DMN) putatively involved in self-referential processes [6] and the salience network (SN) implicated in interoceptive processing [7], have also shown addiction-related impairments. However, whether and how the network-level interactions are disrupted in chronic cocaine users is unknown. Here, we used modular network analysis based on graph theory to examine the modular organization of functional brain networks and the alterations in network-level interactions following chronic use of cocaine.
Hormesis and Female Sex Hormones

Hormone replacement after menopause has in recent years been the subject of intense scientific debate and public interest and has sparked intense research efforts into the biological effects of estrogens and progestagens. However, there are reasons to believe that the doses used and plasma concentrations produced in a large number of studies casts doubt on important aspects of their validity. The concept of hormesis states that a substance can have diametrically different effects depending on the concentration. Even though estrogens and progestagens have proven prone to this kind of dose-response relation in a multitude of studies, the phenomenon remains clearly underappreciated as exemplified by the fact that it is common practice to only use one hormone dose in animal experiments. If care is not taken to adjust the concentrations of estrogens and progestagens to relevant biological conditions, the significance of the results may be questionable. Our aim is to review examples of female sexual steroids demonstrating bidirectional dose-response relations and to discuss this in the perspective of hormesis. Some examples are highlighted in detail, including the effects on cerebral ischemia, inflammation, cardiovascular diseases and anxiety. Hopefully, better understanding of the hormesis phenomenon may result in improved future designs of studies of female sexual steroids.
Impact of heat pump load on distribution networks

Heat pumps can provide domestic heating at a cost that is competitive with oil heating in particular. If the electricity supply contains a significant amount of renewable generation, a move from fossil fuel heating to heat pumps can reduce greenhouse gas emissions. The inherent thermal storage of heat pump installations can also provide the electricity supplier with valuable flexibility. The increase in heat pump installations in the UK and Europe in the last few years poses a challenge for low-voltage networks, because of the use of induction motors to drive the pump compressors. The induction motor load tends to depress voltage, especially on starting. The study includes experimental results, dynamic load modelling, comparison of experimental results and simulation results for various levels of heat pump deployment. The simulations are based on a generic test network designed to capture the main characteristics of UK distribution system practice. The simulations employ DIgSlILENT Power Factory to facilitate dynamic simulations that focus on starting current, voltage variations, active power, reactive power and switching transients.
Groundwater , the State , and the Creation of Irrigation Communities in Llanos del Caudillo , Spain

This article explores the creation of new groundwater-based irrigation communities as a result of the internal colonisation projects of Franco’s government in the 1950s in La Mancha, Central Spain. The literature on Spain’s hydraulic mission has mainly focused on the use and mobilisation of large surface water projects as part of a state-driven modernisation mission promoting irrigation and water management infrastructure without much contextualisation or focus on its operationalisation at the local level. This paper complements this body of work by examining the local socio-political development of government-led irrigation plans in the colonisation town of Llanos del Caudillo. Moreover, the study of Spain’s hydro-politics and colonisation efforts usually focuses on surface water infrastructure while the public promotion of groundwater use has always been relegated to a second place, as it was mainly driven by private initiative. This paper substantiates the role of groundwater within Spain’s hydraulic mission and production of state-sponsored irrigated landscapes.
Comparison of 3T Intracranial Vessel Wall MRI Sequences

BACKGROUND AND PURPOSE: Intracranial vessel wall MR imaging plays an increasing role in diagnosing intracranial vascular diseases. For a complete assessment, pre- and postcontrast sequences are required, and including other sequences, these result in a long scan duration. Ideally, the scan time of the vessel wall sequence should be reduced. The purpose of this study was to evaluate different intracranial vessel wall sequence variants to reduce scan duration, provided an acceptable image quality can be maintained. MATERIALS AND METHODS: Starting from the vessel wall sequence that we use clinically (6:42 minutes), 6 scan variants were tested (scan duration ranging between 4:39 and 8:24 minutes), creating various trade-offs among spatial resolution, SNR, and contrast-to-noise ratio. In total, 15 subjects were scanned on a 3T MR imaging scanner: In 5 subjects, all 7 variants were performed precontrast-only, and in 10 other subjects, the fastest variant (4:39 minutes) and our clinically used variant (6:42 minutes) were performed pre- and postcontrast. RESULTS: The fastest variant (4:39 minutes) had higher or comparable SNRs/contrast-to-noise ratios of the intracranial vessel walls compared with the reference sequence (6:42 minutes). Qualitative assessment showed that the contrast-to-noise ratio was most suppressed in the fastest variant of 4:39 minutes and the variant of 6:42 minutes pre- and postcontrast. SNRs/contrast-to-noise ratios of the fastest variant were all, except one, higher compared with the variant of 6:42 minutes (P < .008). Furthermore, the fastest variant (4:39 minutes) detected all vessel wall lesions identified on the 6:42-minute variant. CONCLUSIONS: A 30% faster vessel wall sequence was developed with high SNRs/contrast-to-noise ratios that resulted in good visibility of the intracranial vessel wall.
Parent–child conflict about children’s tablet use: The role of parental mediation

This study examined the relations of children’s tablet use and parents’ mediation of children’s tablet use with parent–child conflict about such use. A sample of 364 parents of children aged 2–10 years was used to investigate the relations. The results showed that children who spent more time using the tablet had more conflicts with their parents. Also, children who received high amounts of restrictive mediation had more conflicts with their parents about the tablet. Children who often co-used the tablet with their parents had less conflict, however. Significant two-way interactions indicated that while restrictive mediation increased the strength of the relationship between tablet use and conflict, co-use decreased the strength of the relationship.
The Efficacy of Intraoperative Neurophysiological Monitoring to Detect Postoperative Neurological Deficits in Transforaminal Lumbar Interbody Fusion Surgery.

BACKGROUND Despite the extensive use of intraoperative neurophysiological monitoring (IONM) in spinal procedures, there is no standard guideline for what types of IONM tests should be monitored during lumbar procedures with instrumentation. Moreover, the efficacy of IONM during transforaminal lumbar interbody fusion (TLIF) surgery in detecting postoperative neurological deficits has not been well described. OBJECTIVE To analyze waveform changes from individual IONM tests (somatosensory evoked potentials [SSEP], motor evoked potentials [MEP], and electromyography [EMG]) during TLIF and compare the sensitivity and specificity of these tests in order to determine the best combination to detect postoperative neurological deficits. METHODS Two hundred seventy-five consecutive TLIF cases with IONM between 2010 and 2014 were reviewed, and new postoperative sensory and motor deficits were documented. Sensitivity and specificity for each IONM test in detecting postoperative sensory and/or motor deficits were analyzed. RESULTS SSEP and EMG tests were performed on all 275 patients with 66 patients undergoing additional MEP tests. A total of 7 postoperative deficits have been reported: 2 sensory and 5 motor deficits. MEP test had high sensitivity (80.0%) and specificity (100%) in detecting motor deficits. However, SSEP changes failed to detect sensory deficits and EMG test had high false-positive rates for detecting both sensory (100%) and motor deficits (97.3%). CONCLUSION MEP test should be incorporated in monitoring protocols during spinal procedures that involve instrumentations below vertebral level L1 such as TLIF, as it provides high sensitivity and specificity in detecting postoperative motor deficits. In addition, we propose modifying the standard lower extremity SSEP monitoring protocol to correspond to the vertebral levels being operated on.
Technical Note - Signaling Product Quality Through a Trial Period

It has become a ubiquitous practice for firms that sell new products, such as software, to offer consumers time-locked product trial periods free of charge. We identify trial length as a nuanced signaling instrument, which, together with the price signal, a firm can use to communicate proprietary information about its product quality. We show that a high-quality firm offers a longer trial period and sets a higher price, and is rewarded with a higher profit, relative to its low-quality counterpart. Our finding extends to cases where the firm faces ex ante heterogeneous consumers or when the firm competes with an incumbent product. The electronic companion is available at https://doi.org/10.1287/opre.2017. 1675.