Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Artemisinin-Based Combination Therapy on some Selected Liver Function Indices of Pregnant Wistar Albino Rats

Article history: Received on: 28/06/2013 Revised on: 19/08/2013 Accepted on: 08/09/2013 In the risk assessment of the effect of administration of artemisinin-based combination therapy on some selected liver function indices of pregnant wistar albino rats. Fifteen (15) pregnant wistar albino rats were divided into three groups and were allowed to acclimatize to laboratory condition for seven (7) days. Rats in group A served as the control and were administered with normal saline throughout the experimental period of seven (7) days, while rats in group B and C were administered intra-peritoneally with 3 and 6mg/kg body weight of artemisininbased combination therapy respectively throughout the experimental period. Twenty four (24) hours after the last administration, the pregnant wistar albino rats were sacrificed. Blood was obtained by cardiac puncture for analysis of serum ALP, AST, ALT and bilirubin using standard methods and enzyme kits. The result showed that the drug at both 3and 6mg/kg body weight produced a significant (P<0.05) dosage increase in serum AST, ALT and ALP. The ratio of AST: ALT and AST: ALP showed a significant (P<0.05) increase. Similar pattern was also displayed by serum bilirubin concentration. These results are clear manifestations that artemisinin-based combination therapy might pose hepatic injury, hepatobilliary toxicity or complete hepatic damage in pregnant wistar albino rats. Thus, it is suggested that special precaution needs to be exercised on the usage of artemetherlumefantrine in pregnancy.
Social anxiety and peer relationships in early adolescence: A prospective analysis.

Examined relationships over time between social anxiety, friendship qualities, and rejection experiences for 68 early adolescents who had recently relocated. Prospective analyses provide evidence consistent with the view that social anxiety influences the emergence of companionship and intimacy in newly formed friendships but does not play a significant role in determining the frequency of rejection events. Social anxiety also appears to change over time in response to the degree of companionship and intimacy in friendships and to the frequency of rejection experiences.
Business history and international business

Business history and international business are cognate subjects. There are few, if any, studies of international business that do not require a proper study of context. International business decision making must be made relevant by a considered evaluation of the circumstances surrounding that decision. This often means putting it into its historical context. The contributions that the study of international business can make to business history are the input of appropriate theory and appropriate research methods. The best international business theory can illuminate the seemingly disparate strategies of firms in given historical circumstances and can provide an integrated, overarching conceptual structure of the study of business history. The research methods used in international business are also worthy of scrutiny by business historians. As David Cannadine (2008, p. 29) says, as most historians recognise, analysis without narrative loses any sense of the sequencing (and unpredictability) of events through time, while narrative without analysis fails to convey the structural constraints within which events actually take place . there is in practice a long continuum extending from 'pure' narrative to 'pure' analysis, which means that the best history is situated somewhere between these extremes, seeking simultaneously to animate structure and contextualise narrative.
Combining AAM coefficients with LGBP histograms in the multi-kernel SVM framework to detect facial action units

This study presents a combination of geometric and appearance features used to automatically detect Action Units in face images. We use one multi-kernel SVM for each Action Unit we want to detect. The first kernel matrix is computed using Local Gabor Binary Pattern (LGBP) histograms and a histogram intersection kernel. The second kernel matrix is computed from AAM coefficients and a RBF kernel. During the training step, we combine these two type s of features using the recent SimpleMKL algorithm. SVM outputs are then filtered to exploit dynamic relationships between Action Units.
Contextual issues in the construction of computer-based learning programs

Based on the constructive learning theories, particularly constructivism, four contextual issues are identified and discussed in this paper regarding the construction of effective computer-based learning programs, namely topic selection, authenticity, complexity, and multiple perspectives. These four issues are considered essential for effective learning in terms of learners' participation, reasoning and knowledge construction. After a thorough review and discussion of these issues, a generic conceptual model is built, which shows both the interrelationships among the four issues and the measurement variables of each issue. It is expected that the four contextual issues and the generic model can provide invaluable insights toward research in computer-based learning, training and many other related fields, and address the needs of practitioners to develop better computer-based learning programs. Recommendation for further research is also suggested in the end.
The Generation of Idiomatic and Collocational Expressions

Collocations whose semantic content is not or only partially composed from the semantic content of their parts are often viewed as problematic for generation. In this paper a tactical generator combining FUF as the generation engine and HPSG as the grammar framework is presented. It is shown, that the lexicon driven approach to syntactic and semantic processing is well-suited for the generation of idioms exhibiting various degrees of noncompositionality and syntactic restrictions .
Anterior Cruciate Ligament Strain Behavior During Rehabilitation Exercises In Vivo

Before studying the biomechanical effects of rehabili tation exercises on the reconstructed knee, it is impor tant to understand their effects on the normal anterior cruciate ligament. The objective of this investigation was to measure the strain behavior of this ligament dur ing rehabilitation activities in vivo. Participants were pa tient volunteers with normal anterior cruciate ligaments instrumented with the Hall effect transducer. At 10° and 20° of flexion, ligament strain values for active exten sion of the knee with a weight of 45 N applied to a sub ject's lower leg were significantly greater than active motion without the weight. Isometric quadriceps muscle contraction at 15° and 30° also produced a significant increase in ligament strain, while at 60° and 90° of knee flexion there was no change in ligament strain relative to relaxed muscle condition. Simultaneous quadriceps and hamstrings muscles contraction at 15° produced a significant increase in ligament strain compared with the relaxed state but did not strain the ligament at 30°, 60°, and 90° of flexion. Isometric contraction of hamstrings muscles did not produce change in ligament strain at any flexion angle. Exercises that produce low or un strained ligament values, and would not endanger a properly implanted graft, are either dominated by the hamstrings muscle (isometric hamstring), involve quad riceps muscle activity with the knee flexed at 60° or greater (isometric quadriceps, simultaneous quadri ceps and hamstrings contraction), or involve active knee motion between 35° and 90° of flexion.
Correction of the Caulobacter crescentus NA1000 Genome Annotation

Bacterial genome annotations are accumulating rapidly in the GenBank database and the use of automated annotation technologies to create these annotations has become the norm. However, these automated methods commonly result in a small, but significant percentage of genome annotation errors. To improve accuracy and reliability, we analyzed the Caulobacter crescentus NA1000 genome utilizing computer programs Artemis and MICheck to manually examine the third codon position GC content, alignment to a third codon position GC frame plot peak, and matches in the GenBank database. We identified 11 new genes, modified the start site of 113 genes, and changed the reading frame of 38 genes that had been incorrectly annotated. Furthermore, our manual method of identifying protein-coding genes allowed us to remove 112 non-coding regions that had been designated as coding regions. The improved NA1000 genome annotation resulted in a reduction in the use of rare codons since noncoding regions with atypical codon usage were removed from the annotation and 49 new coding regions were added to the annotation. Thus, a more accurate codon usage table was generated as well. These results demonstrate that a comparison of the location of peaks third codon position GC content to the location of protein coding regions could be used to verify the annotation of any genome that has a GC content that is greater than 60%.
Is there a continuum of psychotic experiences in the general population

Summary Aims - Schizophrenia is a severe mental illness that affects 1% of the population. The diagnosis is made according to current diagnostic systems of DSM-1V (American Psychiatric Association, 1994) and ICD-10 (World Health Organisation, 1992), on the basis of characteristic ‘positive’ and ‘negative’ symptoms. The traditional model assumes a categorical view of the schizophrenia syndrome and its core symptoms, in which differences between psychotic symptoms and their normal counterparts are considered to be qualitative. An alternative, dimensional approach assumes that schizophrenia is not a discrete illness entity, but that psychotic symptoms differ in quantitative ways from normal experiences and behaviours. This paper reviews evidence for the continuity of psychotic symptoms with normal experiences, focusing on the symptoms of hallucinations and delusions. Methods - A qualitative review of the relevant literature. Results - The literature suggests that although current epidemiological approaches yield substantial evidence for a continuum view, it is rarely interpreted as such. Conclusions - The traditional concept ofschizophrenia as a homogeneous disease entity has become outdated and is in dire need of a more valid and clinically useful successor. Declaration of Interests Support has been received in the last two years from the Dutch Research Council, The Dutch Ministry of Health, Maastricht University, The Dutch Brain Society, ZON-MW, The Province of Limburg, The Council of Maastricht, Eli Lilly, Janssen-Cilag, Pfizer, Astra-Zeneca and Bristol Meyer Squibb. None of these funding sources represents a conflict of interest in relation to this article.
Memory, Amnesia, and Dissociative Identity Disorder

Virtually all patients with dissociative identity (or multiple personality) disorder manifest interpersonality amnesia, whereby events experienced by a particular personality state or identity are retrievable by that same identity but not by a different one Though considered a hallmark of dissociative identity disorder (DID), interpersonality amnesia has to date attracted little empirical attention. Further, the few studies on the topic typically include just 1 DID patient and a single index of retention In contrast the current experiment involved 9 DID patients and several measures of either explicit or implicit memory Replicating and extending the single-case study of Nissen, Ross, Willingham, MacKenzie, and Schacter (1988), the present results revealed that implicit testing is a necessary but not a sufficient condition for demonstrating transfer of information from one identity to another Specifically, whereas priming in word-stem completion occurred only if the same personality state performed at both study and at test, priming in picture-fragment completion was as robust between different identities as it was within the same identity Discussion focuses on prospects for future research aimed at understanding the nature and scope of interpersonality amnesia
The Rand Health Insurance Study: a summary critique.

The Rand Health Insurance Study (HIS) is the first formal social experiment comparing economies and health outcomes of different health insurance plans. It was initiated by the Rand Corporation in 1974, is now in its summary stage, and is expected to conclude in 1986. The first report of results compared the effects of cost sharing and free care upon health care utilization in fee-forservice (FFS) practice.1 A subsequent report extended a portion of the same data and compared them with data from an HMO.2 The HMO studied was Group Health Cooperative of Puget Sound (GHC). These reports, given visibility and prestige by publication in the New England Journal of Medicine, by Rand sponsorship and by the large size of the supporting grant (an inflation-adjusted cost through fiscal 1985 in ex-
Pulmonary outcomes of off-pump vs on-pump coronary artery bypass surgery in a randomized trial.

STUDY OBJECTIVES Comparison of pulmonary outcomes after off-pump coronary artery bypass (OPCAB) vs on-pump coronary artery grafting with cardiopulmonary bypass (CABG/CPB). STUDY DESIGN We examined preoperative and postoperative respiratory compliance, fluid balance, hemodynamics, arterial blood gases, chest radiographs, spirometry, pulmonary complications, and time to extubation in a prospective trial of 200 patients randomized to OPCAB vs CABG/CPB performed by one surgeon. RESULTS One CABG/CPB patient and two OPCAB patients required mitral valve repair or replacement and were withdrawn. After three crossovers from CABG/CBP to OPCAB and one crossover from OPCAB to CABG, 97 CABG/CPB patients and 100 OPCAB patients remained. There were no significant preoperative demographic differences between groups. Postoperative compliance was reduced more after OPCAB than after CABG/CPB (- 15.4 +/- 10.7 mL/cm H(2)O vs - 11.2 +/- 10.1 mL/cm H(2)O [mean +/- SD]; p = 0.007), associated with rotation of the heart into the right chest to perform posterolateral bypasses (p < 0.001) and the concomitant increased fluid requirements necessary to maintain hemodynamic stability during rotation of the heart. In addition to higher intraoperative fluid intake (4,541 +/- 1,311 mL vs 3,585 +/- 1,033 mL, p < 0.0001), OPCAB patients had higher intraoperative fluid balance (3,903 +/- 1,315 mL vs 1,772 +/- 1,373 mL, p < 0.0001), and higher postoperative pulmonary arterial diastolic pressure (15.0 +/- 5.5 mm Hg vs 11.8 +/- 5.2 mm Hg, p < 0.0001) and central venous pressure (10.4 +/- 4.5 mm Hg vs 8.4 +/- 4.7 mm Hg, p < 0.0001). Despite lower compliance, immediate postoperative Pao(2) on fraction of inspired oxygen of 1.0 (275 +/- 97 torr vs 221 +/- 92 torr, p = 0.001) was higher after OPCAB and extubation was earlier (p = 0.001). Postoperative chest radiographs, spirometry, mortality, reintubation, or readmission for pulmonary complications were not different between groups. CONCLUSIONS Compared to CABG/CPB, OPCAB was associated with a greater reduction in postoperative respiratory compliance associated with increased fluid administration and rotation of the heart into the right chest to perform posterolateral grafts. OPCAB yielded better gas exchange and earlier extubation but no difference in chest radiographs, spirometry, or rates of death, pneumonia, pleural effusion, or pulmonary edema.
Impact of network slicing on 5G Radio Access Networks

Network slicing addresses the deployment of multiple logical networks as independent business operations on a common physical infrastructure. The concept has initially been proposed for the 5th Generation (5G) core network (CN) however, it has not been investigated yet what network slicing would represent to the design of the 5G radio access network (RAN). The paper explains how network slicing may impact several aspects of the 5G RAN design such as the protocol architecture, the design of network functions (NFs) and the management framework that needs to support both the management of the infrastructure to be shared among the slices and the slice operation.
Mobile devices: A phisher's paradise

Mobile devices - especially smartphones - have gained widespread adoption in recent years, due to the plethora of features they offer. The use of such devices for web browsing and accessing email services is also getting continuously more popular. The same holds true with other more sensitive online activities, such as online shopping, contactless payments, and web banking. However, the security mechanisms that are available on smartphones and protect their users from threats on the web are not yet mature, as well as their effectiveness is still questionable. As a result, smartphone users face increased risks when performing sensitive online activities with their devices, compared to desktop/laptop users. In this paper, we present an evaluation of the phishing protection mechanisms that are available with the popular web browsers of Android and iOS. Then, we compare the protection they offer against their desktop counterparts, revealing and analyzing the significant gap between the two.
Significance of Dermatologic Findings in a Cohort of Depleted Uranium–Exposed Veterans of Iraqi Conflicts

BackgroundDepleted uranium (DU)–containing weapons have been used in military operations since 1991. There is interest in following veterans who were occupationally exposed to DU by either inhalation or retention of fragments. A cohort of DU-exposed Gulf War I veterans has been followed longitudinally at the Baltimore Veterans Administration Medical Center since 1993. ObjectiveThe aim was to monitor chronic dermatological findings associated with occupational DU exposure in the 2013 cohort. MethodsThirty-five veterans were evaluated. This study was reviewed and approved by the institutional review board and the Baltimore Veterans Administration Medical Center research service. Depleted uranium exposure was measured using creatinine-adjusted urine uranium concentrations (micrograms of uranium per gram of creatinine [&mgr;gU/gCrea]). Detailed medical histories, physical examinations, and exposure histories were performed. ResultsUsing a cutoff level of 0.1 &mgr;gU/gCrea, 11 veterans were placed in the high-uranium exposure group, whereas 23 veterans were placed in the low-uranium exposure group. Retained fragments were documented in 91% of the high-exposure group versus that in 13% of the low-exposure group (P < 0.001), and fragment-related scarring was significantly increased in the high-exposure group (P = 0.002). Other dermatological findings such as dermatitis were also assessed. ConclusionsFragment retainment and related scarring was significantly increased in veterans exposed to high levels of DU. Continuous monitoring of this cohort will yield interesting dermatological findings related to DU exposure.
Containment of conjunctive queries: beyond relations as sets

Conjwzctiue queries are queries over a relational database and are at the core of relational query languages such as SQL. Testing for containment (and equivalence) of such queries arises as part of many advanced features of query optimization, for example, using rnateriahzed views, processing correlated nested queries, semantic query optimization, and global query optimization. Earlier formal work on the topic has examined conjunctive queries over sets of tuples, where each query can be viewed as a function from sets to sets. Containment (and equivalence) of conjunctive queries has been naturally defined based on set mcluslon and has been shown to be an NP-complete problem. Even in SQL, however, queries over multzsets of tuples may be posed. In fact, relations are treated as multisets by default, with duplicates being ehmmated only after explicit requests Thus, in order to reason about containment/equivalence of a large class of SQL queries, it is necessary to consider a generalization of conjunctive queries, in which relations are interpreted as multmets of tuples: The view of a relation as a set of tuples must be generahzed. In this paper we study conjunctive queries over databases in which each tuple has an associated label. This generalized notion of a database allows us to consider relations that are mcsltzsets and relatlons that are fuzzy sets. As a special case, we can also model traditional set-relatlons by making the label associated with a tuple be either “true” (meaning that the tuple is in the relation) or “false” (meaning that the tuple is not in the relation). In order to keep our results general, we consider a variety of label systems, where each label system is essentially a set of conditions on the labels that can be associated with tuples. Once a result is established for a label system, it holds for all mterpretations of relatlons that satisfy these conditions. For example, we present a necessary and sufficient condition for containment of conjunctive queries for label systems of a type that abstracts both the traditional set-relations and fuzzy sets. We also present a different necessary and sufficient condition for containment of a restricted class of conjunctive queries for a label system that abstracts relations as multlsets. Finally, we show that containment of unions of conjunctwe queries is decidable for label systems of the first type and undecidable for label systems of the second type This result underscores the fundamental difference between viewing relations as sets and as multmets, and motivates a closer examination of relatlons as multisets, given them importance in SQL.
PEGylated insulin Lispro, (LY2605541)—a new basal insulin analogue

There is a clinical rationale for a basal insulin with a predictable action and low inter‐ and intra‐individual variability coupled with an improved side effect and metabolic profile. Since insulin therapy is anabolic and its initiation is commonly associated with weight gain, an insulin preparation associated with a beneficial weight profile would represent a particularly valuable therapeutic entity. LY2605541, or PEGylated insulin Lispro, has a large hydrodynamic size while still exerting the metabolic effects of insulin. This may reduce absorption and clearance of the compound following subcutaneous administration. A number of preclinical and clinical studies have been constructed to evaluate the utility of this novel insulin. The currently available data from preclinical, phase I and phase II studies suggests LY2605541 has a non‐inferior glucose‐lowering efficacy compared to insulin glargine in people with type 1 and type 2 diabetes and may afford a weight‐loss advantage. Pre‐clinical studies indicate that LY2605541 has low mitogenic potency, exerting a preferential hepatic effect on glucose homeostasis. LY2605541 appears to cause elevated transaminases and derangement of lipid profiles. On the basis of these initial observations, LY2605541 requires further extensive clinical evaluation to fully assess its risk/benefit profile in the management in people with diabetes.