Miracle-dz/UniFAR-FTUs huggingface dataset:
Extraperitoneal laparoscopic dismembered fibrin-glued pyeloplasty: medium-term results.

OBJECTIVE To assess the feasibility and results of performing retroperitoneoscopic dismembered fibrin-glued pyeloplasty in a clinical series of patients with pelvi-ureteric junction (PUJ) obstruction. PATIENTS AND METHODS A balloon-dissecting four-port extraperitoneal laparoscopic approach was used in each of nine patients (aged 21-60 years) to dismember the PUJ over a previously placed double-pigtail stent, insert stay sutures to appose the urothelium and complete the pelvi-ureteric anastomosis using fibrin glue. Anastomoses were assessed by diuresis renography 3 months after surgery and at yearly intervals thereafter. RESULTS Eight of the nine attempted procedures were completed successfully in a median (range) operating time of 180 (150-230) min. The median (range) post-operative parenteral opiate requirement was 0 (0-80) mg morphine sulphate and the post-operative hospitalization was 2 (2-4) nights. A shortened fibrotic ureter prevented the laparoscopic completion of the second case, which was converted to an open procedure. Follow-up imaging after 1-2 years showed satisfactory upper tract drainage in those cases completed successfully. One patient developed a renal pelvic calculus that was treated by extracorporeal shock wave lithotripsy. CONCLUSION This technique is associated with a significantly shorter operating time than historical laparoscopic controls, and with a significantly lower post-operative opiate analgesic requirement and shorter post-operative hospitalization than in a contemporaneous series of patients undergoing open pyeloplasty. However, longer term follow-up is needed to fully assess the performance of these anastomoses.
Institutions and Venture Capital

We survey the literature on venture capital and institutions and present a case study comparing the development of the venture capital market in the US to Sweden. Our literature survey underscores that the legal environment, financial market development, the tax system, labor market regulations, and public spending on research and development correlates with venture capital activities across countries. Our case study suggests these institutional differences led to the later development of an active venture capital market in Sweden compared to the US. In particular, a later development of financial markets and a heavier tax burden for entrepreneurs have played a key role.
Rice Two-Pore K+ Channels Are Expressed in Different Types of Vacuoles[W]

The two members of the two-pore potassium (TPK) family in rice have highly similar amino acid sequences and electrophysiological properties and yet are targeted to distinct cellular locations. Whereas TPKa localizes mainly to the tonoplast of the lytic vacuole, TPKb occurs in protein storage vacuoles. This study identifies the domains that are critical for their differential targeting. Potassium (K+) is a major nutrient for plant growth and development. Vacuolar K+ ion channels of the two-pore K+ (TPK) family play an important role in maintaining K+ homeostasis. Several TPK channels were previously shown to be expressed in the lytic vacuole (LV) tonoplast. Plants also contain smaller protein storage vacuoles (PSVs) that contain membrane transporters. However, the mechanisms that define how membrane proteins reach different vacuolar destinations are largely unknown. The Oryza sativa genome encodes two TPK isoforms (TPKa and TPKb) that have very similar sequences and are ubiquitously expressed. The electrophysiological properties of both TPKs were comparable, showing inward rectification and voltage independence. In spite of high levels of similarity in sequence and transport properties, the cellular localization of TPKa and TPKb channels was different, with TPKa localization predominantly at the large LV and TPKb primarily in smaller PSV-type compartments. Trafficking of TPKa was sensitive to brefeldin A, while that of TPKb was not. The use of TPKa:TPKb chimeras showed that C-terminal domains are crucial for the differential targeting of TPKa and TPKb. Site-directed mutagenesis of C-terminal residues that were different between TPKa and TPKb identified three amino acids that are important in determining ultimate vacuolar destination.
Ammonia oxidation pathways and nitrifier denitrification are significant sources of N2O and NO under low oxygen availability

The continuous increase of nitrous oxide (N2O) abundance in the atmosphere is a global concern. Multiple pathways of N2O production occur in soil, but their significance and dependence on oxygen (O2) availability and nitrogen (N) fertilizer source are poorly understood. We examined N2O and nitric oxide (NO) production under 21%, 3%, 1%, 0.5%, and 0% (vol/vol) O2 concentrations following urea or ammonium sulfate [(NH4)2SO4] additions in loam, clay loam, and sandy loam soils that also contained ample nitrate. The contribution of the ammonia (NH3) oxidation pathways (nitrifier nitrification, nitrifier denitrification, and nitrification-coupled denitrification) and heterotrophic denitrification (HD) to N2O production was determined in 36-h incubations in microcosms by 15N-18O isotope and NH3 oxidation inhibition (by 0.01% acetylene) methods. Nitrous oxide and NO production via NH3 oxidation pathways increased as O2 concentrations decreased from 21% to 0.5%. At low (0.5% and 3%) O2 concentrations, nitrifier denitrification contributed between 34% and 66%, and HD between 34% and 50% of total N2O production. Heterotrophic denitrification was responsible for all N2O production at 0% O2. Nitrifier denitrification was the main source of N2O production from ammonical fertilizer under low O2 concentrations with urea producing more N2O than (NH4)2SO4 additions. These findings challenge established thought attributing N2O emissions from soils with high water content to HD due to presumably low O2 availability. Our results imply that management practices that increase soil aeration, e.g., reducing compaction and enhancing soil structure, together with careful selection of fertilizer sources and/or nitrification inhibitors, could decrease N2O production in agricultural soils.
Corneocyte Quantification by NIR Densitometry and UV/Vis Spectroscopy for Human and Porcine Skin and the Role of Skin Cleaning Procedures

Optical methods of corneocyte quantification during tape stripping experiments on the skin are useful tools for the rapid evaluation of the skin penetration potential of dermally applied substances. However, a comparative investigation of the different methods proposed for this task, namely NIR densitometry and UV/Vis spectroscopy, is still missing. Thus, the aim of the present work was to employ these two techniques in comparative tape stripping experiments both in vivo on human forearm skin and in vitro on porcine ear skin. Standard tape stripping experiments were performed in the absence and presence of a marketed formulation containing flufenamic acid as a model drug. In the context of these methodological investigations, different methods of skin cleaning prior to the tape stripping procedure were evaluated to identify the most appropriate working protocol among the approaches proposed in the respective literature. The results showed that the investigated methods of NIR densitometry and UV/Vis spectroscopy deliver highly comparable results. Both optical methods are suitable to determine the skin penetration profiles of active substances during in vivo and in vitro tape stripping, especially if a simple working protocol without any cleaning procedures is maintained.
Urinary biomarkers of tea polyphenols and risk of colorectal cancer in the Shanghai Cohort Study

There have been no studies on specific tea polyphenol biomarkers and risk of colorectal cancer in humans. We prospectively examined the associations between validated biomarkers of specific tea polyphenols and risk of developing colorectal cancer among a cohort of 18,244 men in Shanghai, China, with 16 years of follow‐up. Epigallocatechin (EGC), 4′‐O‐methyl‐epigallocatechin (4′‐MeEGC) and epicatechin, and their metabolites in baseline urine samples were measured on 162 incident colorectal cancer cases and 806 matched controls. Individuals with high prediagnostic urinary EGC levels had a lower risk of colon cancer. Compared with undetectable EGC, odds ratios (95% confidence interval) for colon cancer in the lowest, intermediate and highest tertile of detectable EGC were 0.64 (0.33–1.24), 0.60 (0.30–1.20) and 0.40 (0.19–0.83), respectively (p for trend = 0.02). A similar inverse relation between 4′‐MeEGC and colon cancer also was observed. Compared with the lowest quartile, odds ratios (95% confidence intervals) for colon cancer in the 2nd, 3rd and 4th quartiles of urinary 4′‐MeEGC were 0.49 (0.25–0.96), 0.32 (0.16–0.67) and 0.41 (0.20–0.84), respectively (p for trend = 0.006). The strongest protective effect was seen for regular tea drinkers who showed high levels of urinary EGC and 4′‐MeEGC. No association between urinary levels of epicatechin or its metabolite and colon cancer risk was observed. Urinary levels of tea polyphenols and their metabolites were not associated with rectal cancer risk. The present study supports the notion of tea catechins as chemopreventive agents against the development of colon cancer in humans. © 2006 Wiley‐Liss, Inc.
Negotiation as the Driving Force of Environmental Citizenship

A precise understanding of ‘social public’ processes is of utmost importance to environmental risk managers and their communicators and/or negotiators, as it enables them to responsibly, ‘participatorily’ and therefore effectively plan and implement their risk communication activities, leading to successful completion of the environmental risk project for all the parties involved. Communicators should therefore strive to find out as much as possible about different levels of the risk debate, relating to factual evidence, personal and institutional experience and judgement, and social identification (world-view). An adapted, indirect use of the Social Amplification of Risk Framework (SARF) model and the layering method for analysing the risk debate level is highly recommended for experts, decision-makers and above all their communicators/negotiators in environmental but also in several other risk-communication areas.
Size and scope of the underground economy in Germany

The objective of this paper is to improve estimations of the size and scope of the underground economy by introducing a new approach that combines the advantages of the two most commonly used approaches, i.e. currency demand and multiple indicators, multiple causes (MIMIC). The new approach is applied to Germany. Among other things, it is shown that the approach yields improved estimation results. Some policy perspectives are discussed in the concluding section.
Fundamental vs. Technical Analysis

This article addresses the following key points: Technical analysis is based on the belief that the market is not efficient. Technical analysts use indicators that are independent of the company's financial condition. Fundamental analysts focus on the financial health of companies. Fundamental analysis chooses stocks to buy; technical analysis chooses when to buy for analysts who use both. Proponents of strong form efficient market theory and technical analysts are at opposite ends of the philosophical spectrum.
The New Institutional Economics

Current English policy towards general practice is ambivalent between developing new forms of contractual governance and constructing more hierarchically organized bodies. NHS policy documents say that Primary Care Trusts (PCTs) will contract some primary care services and directly manage others. Depending on the balance, PCTs could either organize general practice through practice-based contracts or start developing into hierarchies (albeit with some subcontractors for the time being). New Institutional Economics, in particular Williamson's version, defines conditions where hierarchies are likely to be more efficient than markets (in terms of what welfare economics recognizes as allocative efficiency) and conditions where the reverse holds. This article considers the implications of the New Institutional Economics (NIE) for redesigning the governance of publicly financed services such as general practice which allow direct public access, in which it is difficult to define and manage service quality, and which have a professionalized but fragmented workforce. In contrast to their alleged implications for the hospital sector during the 1990s, NIE theories imply that for publicly funded professional services such as general practice there are stronger economic arguments for constructing hierarchies than for reconstructing quasi-markets at local level.
Understanding First-day Returns of Hospitality Initial Public Offerings

Excerpt] The decision for a company to issue shares publicly for the first time is not to be taken lightly. The manager-owner of a private firm must carefully weigh the benefits of an initial public offering (IPO) against the costs. Potential benefits include the ability to raise capital in the public markets on more attractive terms than in private circles; increased liquidity for managers and other insiders who wish to sell ownership stakes; and increased recognition and credibility with customers, employees, and suppliers. These benefits, however, come at considerable direct and indirect costs. For U.S. firms, the direct costs, such as investment banking commissions, average about 11 percent of IPO proceeds.1 Less obvious, but sometimes more painful for issuing firms, is an additional indirect cost commonly referred to as “IPO underpricing. ”
Knowledge-based Correction of Flash-lag Illusion

A flash is perceived to lag spatially behind a moving object even when the two retinal images are physically aligned (flash-lag effect, FLE). Here we show that this robust illusion can be diminished by a knowledge of letters in the observer's brain. When moving and flashed segments in the FLE made the shape of a Kanji letter (ideographic characters used in Japan), the magnitude of the illusory lag perceived by Japanese subjects was significantly reduced compared to when conventional geometric (nonletter) segments were used. This diminishment was not observed when a pseudo-Kanji letter was presented to Japanese subjects or when non-Japanese English-speakers (who do not have a knowledge of Kanji) saw a real Kanji letter, indicating that the reduction in the FLE was induced by a retrieval of the knowledge (shapes of letters) stored in the observer's brain. Furthermore, measurements of neural activities by magnetoencephalography showed that the initial brain response, in which the effect of the knowledge became evident, occurred as early as 160 msec after the appearance of the flashed segment. These results demonstrated a substantial influence of knowledge on the flash-lag illusion and further suggest a rapid response of the knowledge-based perceptual pathway in the human brain.
Putative role of lysyl hydroxylation and pyridinoline cross-linking during adolescence in the occurrence of osteoarthritis at old age.

OBJECTIVE The collagen network in human articular cartilage experiences a large number of stress cycles during life as it shows hardly any turnover after adolescence. We hypothesized that, to withstand fatigue failure, the physical condition of the collagen network laid down at adolescence is of crucial importance for the age of onset of osteoarthritis (OA). METHODS We have compared the lysyl hydroxylation level and pyridinoline cross-link level of the collagen network of degenerated (DG) cartilage of the femoral knee condyle (representing a preclinical early stage of OA) with that of normal cartilage from the contralateral knee. The biological age of the collagen network was determined by means of pentosidine levels. For each donor, collagen modifications of normal cartilage were compared with DG cartilage that showed no significant remodeling of the collagen network (as evidenced by identical pentosidine levels). RESULTS DG cartilage contained significantly more hydroxylysine residues per collagen molecule in comparison with healthy cartilage from the same donor, both in the upper and lower half (the region near the articular surface and adjacent to bone, respectively). In addition, a significantly higher level of pyridinoline cross-linking was observed in the upper half of DG cartilage. Considering the biological age of the collagen network, the changes observed in DG cartilage must have been present several decades before cartilage became degenerated. CONCLUSIONS The data suggest that high levels of lysyl hydroxylation and pyridinoline cross-linking result in a collagen network that fails mechanically in long term loading. Areas containing collagen with low hydroxylysine and pyridinoline levels are less prone to degeneration. As such, this study indicates that post-translational modifications of collagen molecules synthesized during adolescence are causally involved in the pathogenesis of OA.
Strategic Manipulation in Multiple Attribute Decision Making with Interval Evaluation

Strategic manipulation or non-cooperative behavior means that decision makers will make dishonest decisions or changes their decision according to their own interests. In this paper, strategic manipulation is applied to multiple attribute decision making (MADM), in which decision makers can manipulate ranking results through attribute weights. In view of uncertainty evaluations in decision making, the alternative evaluations are assumed to be represented in interval values, and a final decision result can be obtained by aggregating the interval evaluations of alternatives under different attribute weights. Firstly, a model is established to estimate the ranking of all alternatives, and a strategic manipulation model is further established to obtain the desired ranking by manipulating attribute weights. The proposed method can better conform to the actual situation by considering the uncertainty. Finally, the method is applied to the university ranking to obtain the desired ranking results and help decision makers choose the attribute weights according to their desired ranking of universities. Numerical simulation also verifies the effectiveness and rationality of the proposed method.
Canadian Evidence on the Constructive Capitalization of Operating Leases

One type of relevant ex ante research supporting the accounting standardâ€ setting process is the study of a proposed standard's impact on reported figures. The International Accounting Standards Board recently decided to review the lease accounting standard, which will naturally involve consideration of the G4 + 1 recommendation to capitalize all noncancellable lease contracts, including operating leases. National evidence of the impact of the G4 + 1 proposals provides feedback for the international standardâ€ setter. This study developed and used a refined constructive capitalization method, in which companyâ€ specific assumptions â€” interest rate, total/expired/remaining lives of leased assets, and tax rate â€” were used to compute the impact of operatingâ€ lease capitalization on key financial indicators for a sample of Canadian public companies. The results indicate that capitalizing operating leases would lead to the recognition of important additional assets and liabilities on the balance sheet. It would therefore significantly increase the debtâ€ toâ€ asset ratio and significantly decrease the current ratio. These results were noted across all industry segments in the sample. Income statement effects were generally less material. Significant impacts on return on assets, return on equity, and / or earnings per share were noted in only three industry segments: merchandising and lodging, oil and gas, and financial services. Intercompany comparability would not be affected overall nor within industries, because of similar rankings for each financial indicator before and after operatingâ€ lease capitalization.
Managing funds in the US market: how to distinguish between transitory distortions and structural changes in the stock prices?

The paper reports estimates of a reliable fundamental value of the S&P index, standing for a long run target value in Error-Correction Modelling of the dynamics of subsequent returns. The Present Value Model suggests two fundamentals: dividends and a discount rate factor, specified as a risk free rate plus an ex ante risk premium, to capture structural breaks in the expectations. The dates of the shifts are identified by estimating recursively a cointegration relationship. Monte Carlo simulations are used to compute appropriate statistics for stationarity tests. The predictive performance of the Error-Correcting Model is then used to implement winning portfolio-investment strategies.
The access of business interests to EU institutions: towards élite pluralism?

Abstract It has often been suggested that bias in the access of interest organizations to policy-makers leads to biased policies. The paper analyses the access of interest organizations to the EU institutions drawing on data from 800 business interest associations and 34 large firms. Exploring the proposition that some form of élite pluralism may emerge in the EU, it argues that the contact patterns derive from resource dependencies among the political actors and the interest groups, institutional opportunities in the EU, and the characteristics of the interest organizations. The study identifies imbalances in the access of EU associations, large firms, and national associations to the EU institutions, with large firms being in the forefront. Nonetheless, the evidence does not hint at the emergence of élite pluralism in the EU but points to important variations across the EU institutions and among the working level and their political leadership in each institution.
From the National Institute of Allergy and Infectious Diseases. Summary of the 27th United States-Japan Joint Conference on Cholera and Related Diarrheal Diseases

The 31 st United States-Japan Cholera and Related Diarrheal Diseases Conference was held in conjunction with the United States-Japan Malnutrition Conference at Kiawah Island, South Carolina, 30 November to 3 December 1995. In addition to the overall conference theme of the role of cytokines in the pathogenesis of enteric infections and malnutrition, researchers described substantial advances in cholera epidemiology, detection, molecular mechanisms, and pathophysiology plus new mechanisms for enterotoxigenic, enteroadherent, enterohemorrhagic, and enteroinvasive Escherichia coli. There was also emphasis on new work with and vaccine development with Bacteroidesfragilis and Yersinia, Shigella, and Salmonella species.
The Current State of Professional Forestry Education in the United Kingdom

SUMMARY Enrolments to Higher Education forestry courses have been in decline in the UK over the last decade. This trend has sparked widespread concern about the future of professional forestry education and recruitment of qualified graduates to the forestry sector. It is not clear if this decline is cyclical, or a permanent loss of interest in forestry as a university course and career option. A complex range of factors are responsible for the current situation; some are related to the education system in the UK, some to the forestry sector, and some are socio-economic and cultural. Nonetheless, a similar pattern of decline in recent years has been seen in other natural resource disciplines, most notably agriculture, leading to the closure or merger of several university departments. This paper explores some of the issues that need to be addressed in order that forestry remains a relevant, viable and attractive university course.