Miracle-dz/UniFAR-FTUs huggingface dataset:
Maximum Damage Malware Attack in Mobile Wireless Networks

Malware attacks constitute a serious security risk that threatens to slow down the large scale proliferation of wireless applications. As a first step towards thwarting this security threat, we seek to quantify the maximum damage inflicted on the system owing to such outbreaks and identify the most vicious attacks. We represent the propagation of malware in a battery-constrained mobile wireless network by an epidemic model in which the worm can dynamically control the rate at which it kills the infected node and also the transmission range and/or the media scanning rate. At each moment of time, the worm at each node faces the following trade-offs: (i)~using larger transmission range and media scanning rate to accelerate its spread at the cost of exhausting the battery and thereby reducing the overall infection propagation rate in the long run or (ii)~killing the node to inflict a large cost on the network, however at the expense of loosing the chance of infecting more susceptible nodes at later times. We mathematically formulate the decision problems and utilize Pontryagin Maximum Principle from optimal control theory to quantify the damage that the malware can inflict on the network by deploying optimum decision rules. Next, we establish structural properties of the optimal strategy of the attacker over time. Specifically, we prove that it is optimal for the attacker to defer killing of the infective nodes in the propagation phase until reaching a certain time and then start the slaughter with maximum effort. We also show that in the optimal attack policy, the battery resources are used according to a decreasing function of time, i.e., mostly during the initial phase of the outbreak. Finally, our numerical investigations reveal a framework for identifying intelligent defense strategies that can limit the damage by appropriately selecting network parameters.
Antibacterial activity of essential oils from Eucalyptus and of selected components against multidrug-resistant bacterial pathogens

Context: Eucalyptus globulus Labill (Myrtaceae) is the principal source of eucalyptus oil in the world and has been used as an antiseptic and for relieving symptoms of cough, cold, sore throat, and other infections. The oil, well known as ‘eucalyptus oil’ commercially, has been produced from the leaves. Biological properties of the essential oil of fruits from E. globulus have not been investigated much. Objective: The present study was performed to examine the antimicrobial activity of the fruit oil of E. globulus (EGF) and the leaf oils of E. globulus (EGL), E. radiata Sieber ex DC (ERL) and E. citriodora Hook (ECL) against multidrug-resistant (MDR) bacteria. Furthermore, this study was attempted to characterize the oils as well as to establish a relationship between the chemical composition and the corresponding antimicrobial properties. Materials and methods: The chemical composition of the oils was analyzed by GLC-MS. The oils and isolated major components of the oils were tested against MDR bacteria using the broth microdilution method. Results: EGF exerted the most pronounced activity against methicillin-resistant Staphylococcus aureus (MIC ~ 250 µg/ml). EGF mainly consisted of aromadendrene (31.17%), whereas ECL had citronellal (90.07%) and citronellol (4.32%) as the major compounds. 1,8-cineole was most abundant in EGL (86.51%) and ERL (82.66%). Discussion and conclusion: The activity of the oils can be ranked as EGF > ECL > ERL ~ EGL. However, all the oils and the components were hardly active against MDR Gram-negative bacteria. Aromadendrene was found to be the most active, followed by citronellol, citronellal and 1,8-cineole.
Eigen Based Traffic Sign Recognition Which Aids In Achieving Intelligent Speed Adaptation

Abstract Speed is one of the major factors by which the traffic safety is affected. If the speed limit traffic signs on the road are recognised and displayed to a driver, this will be a motivation to keep the vehicle's speed within the permitted range. The purpose of this paper is to investigate Eigen-based traffic sign recognition which can aid in the development of Intelligent Speed Adaptation. This system is based on invoking the PCA technique to detect the unknown speed limit traffic sign and computes its best effective Eigen vectors. The traffic sign is then recognized and classified by using the shortest Euclidean distance to the different speed limit traffic sign classes. The system was trained using 24 037 images which were collected in different light conditions. To check the robustness of this system, it was tested against 1429 images and it was found that the accuracy of recognition was 97.5% which indicates clearly the high robustness targeted by this system.
The effect of platelet enriched plasma on clinical outcomes in patients with femoroacetabular impingement following arthroscopic labral repair and femoral neck osteoplasty

To compare the clinical outcome of patients treated with and without platelet-rich plasma (PRP) injection while undergoing arthroscopic labral repair and femoral neck osteoplasty for femoral acetabular impingement. Patients were randomized at the time of surgery to receive either an intra-articular injection of 5 cc of PRP, or an equal volume of 0.9% normal saline. All patients underwent arthroscopic labral repair and osteoplasty of the femoral neck and, at the conclusion of the case, received the injection. One week following surgery, thigh circumference (measured 10 cm distal to the tip of the greater trochanter) and the presence of ecchymosis of the thigh were recorded. Clinical outcome scores, including Non-Arthritic Hip Score, Modified Harris Hip Score and Hip Outcome Score were collected prior to surgery at 1, 3, 6 and a minimum of 12 months post-operatively. Thirty-five patients were enrolled into this study. Twenty patients received a PRP injection and 15 received a saline injection. Thigh circumference was compared pre-operatively and 1 week post-operatively. There was no significant difference between the two groups. Ecchymosis was compared between the two groups at 1 week post-operatively. Four of the 20 patients in the PRP group and 10 of the 15 in the placebo group demonstrated bruising on the lateral thigh. This was compared with a Chi-Square test and found to be statistically significant (P = 0.005). There was no significant difference in any of the outcome scores between the two groups. An intra-articular injection of PRP after labral repair did not improve the clinical outcome up to 1 year post-operatively in patients undergoing arthroscopic labral repair and osteoplasty of the femoral neck. Level of evidence is level I study.
A preliminary study on heuristics for mobile games

Playtesting and expert evaluation methods are common these days to evaluate games. In order to find out playability problems in mobile games, an evaluation method is needed to evaluate mobile games with a set of playability heuristics. Heuristics evaluation method is good for identifying playability problems deeply but a set of playability heuristics is needed to apply this method. This research is conducted to identify and explore more playability problems in mobile games. It has been reviewed that some of the problems were still unidentified by evaluators when they evaluated the games with present playability heuristics set. In this research some problems were identified from literature analysis and survey results. This research has been conducted by using survey methodology tools (interviews & questionnaire), the questionnaire is divided into 3 sections and it contains 20 questions. 100 questionnaires were distributed among university students and all were returned with positive feedback. The outcome of this research proposed some new playability heuristics for mobile games, in order to identify playability problems. Consequently, these heuristics may help game designers and developers while considering these heuristics during development of mobile games.
Sustained elevation of neutrophils in rats induced by lentivirus‐mediated G‐CSF delivery

Patients with severe chronic and cyclic neutropenia, characterized by neutrophil numbers <500 cells/µl, are treated daily with recombinant granulocyte colony‐stimulating factor (G‐CSF). As an alternative delivery approach we investigated the ability of lentivirus vectors to provide sustained G‐CSF expression.
Transcriptional activation of the glycolytic las operon and catabolite repression of the gal operon in Lactococcus lactis are mediated by the catabolite control protein CcpA

The Lactococcus lactis ccpA gene, encoding the global regulatory protein CcpA, was identified and characterized. Northern blot and primer extension analyses showed that the L. lactis ccpA gene is constitutively transcribed from a promoter that does not contain a cre sequence. Inactivation of the ccpA gene resulted in a twofold reduction in the growth rate compared with the wild type on glucose, sucrose and fructose, while growth on galactose was almost completely abolished. The observed growth defects could be complemented by the expression of either the L. lactis or the Bacillus subtilis ccpA gene. The disruption of the ccpA gene reduced the catabolite repression of the gal operon, which contains a cre site at the transcription start site and encodes enzymes involved in galactose catabolism. In contrast, CcpA activates the transcription of the cre‐containing promoter of the las operon, encoding the glycolytic enzymes phosphofructokinase, pyruvate kinase and L‐lactate dehydrogenase, because its transcription level was fourfold reduced in the ccpA mutant strain compared with the wild‐type strain. The lower activities of pyruvate kinase and L‐lactate dehydrogenase in the ccpA mutant strain resulted in the production of metabolites characteristic of a mixed‐acid fermentation, whereas the fermentation pattern of the wild‐type strain was essentially homolactic.
Calf Note # 149 – Group housing and weaning strategies

Calf management, feeding and housing strategies are continually refined in light of new research to help calves reach their full genetic potential. One strategy – separating newborn calves from each other in individual housing – has been evaluated periodically, more recently in light of increased availability of computerized calf feeders in the U.S. According to USDA, 74.9% of dairy operations in the U.S. housed calves individually prior to weaning in 2006. Group housing is also increasing in some countries as governments require calves be grouped for welfare concerns.
False Discovery Rate Control and Statistical Quality Assessment of Annotators in Crowdsourced Ranking

With the rapid growth of crowdsourcing platforms it has become easy and relatively inexpensive to collect a dataset labeled by multiple annotators in a short time. However due to the lack of control over the quality of the annotators, some abnormal annotators may be affected by position bias which can potentially degrade the quality of the final consensus labels. In this paper we introduce a statistical framework to model and detect annotator's position bias in order to control the false discovery rate (FDR) without a prior knowledge on the amount of biased annotators - the expected fraction of false discoveries among all discoveries being not too high, in order to assure that most of the discoveries are indeed true and replicable. The key technical development relies on some new knockoff filters adapted to our problem and new algorithms based on the Inverse Scale Space dynamics whose discretization is potentially suitable for large scale crowdsourcing data analysis. Our studies are supported by experiments with both simulated examples and real-world data. The proposed framework provides us a useful tool for quantitatively studying annotator's abnormal behavior in crowdsourcing data arising from machine learning, sociology, computer vision, multimedia, etc.
Joint Optimization of Signal Phasing and Timing and Vehicle Speed Guidance in a Connected and Autonomous Vehicle Environment

A joint traffic signal optimization algorithm is proposed which utilizes connected vehicle (CV) information to identify optimum signal timing and phasing plans while also providing speed guidance to individual vehicles to minimize total number of stopping maneuvers. The contribution of this paper is provision of speed guidance to both autonomous (AVs) and human-driven speed guidance-enabled vehicles (SGVs), recognizing that the latter may not fully comply with the speed guidance and would require some delay (i.e., reaction time) to implement it. The control algorithm is triggered at regular discrete time intervals during which CV information is used to identify the presence of non-CVs and incorporate them into signal timing decision-making. Optimal speeds are determined for any AVs or SGVs so that they can travel through the intersection at the expected departure time without stopping, considering both acceleration/deceleration and human reaction times. Simulation tests are performed under different CV, AV, and SGV penetration rates, while explicitly modeling the potential human errors and varying acceptance levels. The results suggest that average delay and number of stops decrease with higher CV penetration rate. Furthermore, the number of stops decreases as the ratio of both AVs and SGVs increases. While AVs are about 10% more efficient than SGVs, human-driven vehicles still provide a benefit even when they do not fully comply with speed guidance information. Sensitivity tests suggest that operation is not significantly affected by the range of human driver errors in speed compliance or range of reaction times.
Germline and Somatic Mutations in Homologous Recombination Genes Predict Platinum Response and Survival in Ovarian, Fallopian Tube, and Peritoneal Carcinomas

Purpose: Hallmarks of germline BRCA1/2-associated ovarian carcinomas include chemosensitivity and improved survival. The therapeutic impact of somatic BRCA1/2 mutations and mutations in other homologous recombination DNA repair genes is uncertain. Experimental Design: Using targeted capture and massively parallel genomic sequencing, we assessed 390 ovarian carcinomas for germline and somatic loss-of-function mutations in 30 genes, including BRCA1, BRCA2, and 11 other genes in the homologous recombination pathway. Results: Thirty-one percent of ovarian carcinomas had a deleterious germline (24%) and/or somatic (9%) mutation in one or more of the 13 homologous recombination genes: BRCA1, BRCA2, ATM, BARD1, BRIP1, CHEK1, CHEK2, FAM175A, MRE11A, NBN, PALB2, RAD51C, and RAD51D. Nonserous ovarian carcinomas had similar rates of homologous recombination mutations to serous carcinomas (28% vs. 31%, P = 0.6), including clear cell, endometrioid, and carcinosarcoma. The presence of germline and somatic homologous recombination mutations was highly predictive of primary platinum sensitivity (P = 0.0002) and improved overall survival (P = 0.0006), with a median overall survival of 66 months in germline homologous recombination mutation carriers, 59 months in cases with a somatic homologous recombination mutation, and 41 months for cases without a homologous recombination mutation. Conclusions: Germline or somatic mutations in homologous recombination genes are present in almost one third of ovarian carcinomas, including both serous and nonserous histologies. Somatic BRCA1/2 mutations and mutations in other homologous recombination genes have a similar positive impact on overall survival and platinum responsiveness as germline BRCA1/2 mutations. The similar rate of homologous recombination mutations in nonserous carcinomas supports their inclusion in PARP inhibitor clinical trials. Clin Cancer Res; 20(3); 764–75. ©2013 AACR.
LACTATIONAL AMENORRHOEA IN WELL-NOURISHED TOBA WOMEN OF FORMOSA, ARGENTINA

The proximate causes of the contraceptive effect of lactation are still a matter of productive debate. This study sought to disentangle the relative impact that intense breast-feeding practices and maternal nutrition have on the regulation of ovarian function in nursing women. A mixed-longitudinal, direct-observational, prospective study was conducted of the return to postpartum fecundity in 113 breast-feeding, well-nourished Toba women. A sub-sample of 70 women provided data on nursing behaviour, daily activities, diet quality and urinary levels of oestrone and progesterone metabolites. Well-nourished, intensively breast-feeding Toba women experienced a relatively short period of lactational amenorrhoea (10·2±4·3 months) and a high lifetime fertility (TFR=6·7 live births/woman). Duration of lactational amenorrhoea was not correlated with any of the nursing parameters under study or with static measures of maternal nutritional status. The results indicated that the pattern of resumption of postpartum fertility could be explained, at least partly, by differences in individual metabolic budgets. Toba women resumed postpartum ovulation after a period of sustained positive energy balance. As the relative metabolic load hypothesis suggests, the variable effect of lactation on postpartum fertility may not depend on the intensity of nursing per se but rather on the energetic stress that lactation represents for the individual mother.
Wireless Personal Communications: A Perspective

▶ Publishes tutorial, survey, and original research papers addressing mobile communications and computing ▶ Investigates theoretical, engineering, and experimental aspects of radio communications, voice, data, images, and multimedia ▶ Explores propagation, system models, speech and image coding, multiple access techniques, protocols performance evaluation, radio local area networks, and networking and architectures, etc ▶ 98% of authors who answered a survey reported that they would definitely publish or probably publish in the journal again
The Gut Bacterium Bacteroides thetaiotaomicron Influences the Virulence Potential of the Enterohemorrhagic Escherichia coli O103:H25

Enterohemorrhagic E. coli (EHEC) is associated with severe gastrointestinal disease. Upon entering the gastrointestinal tract, EHEC is exposed to a fluctuating environment and a myriad of other bacterial species. To establish an infection, EHEC strains have to modulate their gene expression according to the GI tract environment. In order to explore the interspecies interactions between EHEC and an human intestinal commensal, the global gene expression profile was determined of EHEC O103:H25 (EHEC NIPH-11060424) co-cultured with B. thetaiotaomicron (CCUG 10774) or grown in the presence of spent medium from B. thetaiotaomicron. Microarray analysis revealed that approximately 1% of the EHEC NIPH-11060424 genes were significantly up-regulated both in co-culture (30 genes) and in the presence of spent medium (44 genes), and that the affected genes differed between the two conditions. In co-culture, genes encoding structural components of the type three secretion system were among the most affected genes with an almost 4-fold up-regulation, while the most affected genes in spent medium were involved in chemotaxis and were more than 3-fold up-regulated. The operons for type three secretion system (TTSS) are located on the Locus of enterocyte effacement (LEE) pathogenicity island, and qPCR showed that genes of all five operons (LEE1-LEE5) were up-regulated. Moreover, an increased adherence to HeLa cells was observed in EHEC NIPH-11060424 exposed to B. thetaiotaomicron. Expression of stx2 genes, encoding the main virulence factor of EHEC, was down-regulated in both conditions (co-culture/spent medium). These results show that expression of EHEC genes involved in colonization and virulence is modulated in response to direct interspecies contact between cells, or to diffusible factors released from B. thetaiotaomicron. Such interspecies interactions could allow the pathogen to recognize its predilection site and modulate its behaviour accordingly, thus increasing the efficiency of colonization of the colon mucosa, facilitating its persistence and increasing its virulence potential.
Three-Dimensional Channel Characteristics for Molecular Communications With an Absorbing Receiver

Within the domain of molecular communications, researchers mimic the techniques in nature to come up with alternative communication methods for collaborating nanomachines. This letter investigates the channel transfer function for molecular communications via diffusion. In nature, information-carrying molecules are generally absorbed by the target node via receptors. Using the concentration function, without considering the absorption process, as the channel transfer function implicitly assumes that the receiver node does not affect the system. In this letter, we propose a solid analytical formulation and analyze the signal metrics (attenuation and propagation delay) for molecular communication via diffusion channel with an absorbing receiver in a 3-D environment. The proposed model and the formulation match well with the simulations without any normalization.
Parameter estimation method of F0 control model for singing voices

In this paper, we propose a novel representation of F0 contours that provides a computationally efficient algorithm for automatically estimating the parameters of a F0 control model for singing voices. Although the best known F0 control model, based on a second-order system with a piece-wise constant function as its input, can generate F0 contours of natural singing voices, this model has no means of learning the model parameters from observed F0 contours automatically. Therefore, by modeling the piece-wise constant function by Hidden Markov Models (HMM) and approximating the second order differential equation by the difference equation, we estimate model parameters optimally based on iteration of Viterbi training and an LPC-like solver. Our representation is a generative model and can identify both the target musical note sequence and the dynamics of singing behaviors included in the F0 contours. Our experimental results show that the proposed method can separate the dynamics from the target musical note sequence and generate the F0 contours using estimated model parameters.
Daratumumab in combination with urelumab to potentiate anti-myeloma activity in lymphocyte-deficient mice reconstituted with human NK cells

ABSTRACT Daratumumab is an anti-CD38 fully human IgG1 mAb approved for multiple myeloma treatment. One of the proposed mechanisms of action is the induction of antibody-dependent cellular cytotoxicity (ADCC) mediated by NK cells. NK cells acquire surface CD137 expression in the presence of solid-phase-attached daratumumab and when encountering a daratumumab-coated CD38+ tumor cell line. In this setting, addition of the agonist anti-CD137 mAb urelumab enhances NK-cell activation increasing CD25 expression and IFNɣ production. However, in vitro ADCC is not increased by the addition of urelumab both in 4h or 24h lasting experiments. To study urelumab-increased daratumumab-mediated ADCC activity in vivo, we set up a mouse model based on the intravenous administration of a luciferase-transfected multiple myeloma cell line of human origin, human NK cells and daratumumab to immuno-deficient NSG mice. In this model, intravenous administration of urelumab 24h after daratumumab delayed tumor growth and prolonged mice survival.