Miracle-dz/UniFAR-FTUs huggingface dataset:
Using the "negative attitude toward robots scale" with telepresence robots

Nomura et al. designed and piloted the Negative Attitude toward Robots Scale (NARS) in 2003 [18]. NARS has been used by researchers to understand the attitudes of different people towards robots under different circumstances. To our knowledge, NARS has only been used with robots perceived to be autonomous. Our goal was to evaluate if NARS could be extended to robots that were known to have a human in the loop. Towards this end, we verified the validity of the scale with telepresence robots using an online video survey. We found differences across different cultures and gender much like other researcher in the past. Once the consistency of the scale was verified, we used NARS in our second study that involved the use of telepresence robots.
Fighter : Planning in a Highly-Dynamic Game

This paper proposes a plan creation and execution system used by the agent HTN Fighter in the Fighting ICE game framework. The underlying approach implements a Hierarchical Task Network (HTN) planner and a simple planning domain that focuses on sequences of close-range attacks. The execution process is tightly interleaved with the planning process compensating for the uncertainty caused by the delay of 15 frames which the information about the game world state is provided with. Using an HTN and the proposed execution system, the agent is able to follow high-level strategies staying reactive to changes in the environment. Experiments show that HTN Fighter outperforms the sample MCTS controller and the top three controllers submitted to the 2016 Fighting Game AI Competition.
Large deviations theory for Markov jump models of chemical reaction networks

We prove a sample path Large Deviation Principle (LDP) for a class of jump processes whose rates are not uniformly Lipschitz continuous in phase space. Building on it we further establish the corresponding Wentzell-Freidlin (W-F) (infinite time horizon) asymptotic theory. These results apply to jump Markov processes that model the dynamics of chemical reaction networks under mass action kinetics, on a microscopic scale. We provide natural sufficient topological conditions for the applicability of our LDP and W-F results. This then justifies the computation of non-equilibrium potential and exponential transition time estimates between different attractors in the large volume limit, for systems that are beyond the reach of standard chemical reaction network theory.
Antibodies to infliximab in Remicade-treated rheumatic patients show identical reactivity towards biosimilars

Objectives The aim of this study was to determine whether antibodies to infliximab (IFX) in Remicade-treated patients cross-react with the biosimilar CT-P13. Methods 250 consecutive patients with rheumatic diseases under Remicade and 77 controls were retrospectively selected for the study. Anti-IFX antibodies at drug through levels were measured in parallel with three different bridging ELISA assays: Promonitor-ANTI-IFX kit, which uses Remicade to detect antibodies, and two more assays that use either Inflectra or Remsima with the same format. Correlation and association between each assay was studied. Results 50.4% of patients were tested positive with Promonitor-ANTI-IFX. All were antibodies to IFX (ATI)-positive when either Inflectra or Remsima assays were used. In all comparisons positive and negative percentage agreements were 100%, and correlation coefficients were ≥0.995. No differences between rheumatoid arthritis and spondyloarthritis, or between concomitant immunosuppressives, were observed. Conclusions Anti-IFX antibodies of Remicade-treated patients cross-react with either Inflectra or Remsima. Although additional epitopes may be present in the biosimilar, results suggest that epitopes influencing the immune response to IFX are also present in the biosimilar. Antibody-positive patients treated with Remicade should not be switched to the biosimilar, since antibodies will interact with the new drug and potentially lead to loss of response. This finding supports the utility for therapeutic drug monitoring before a switching strategy is considered.
EFFECTS OF THE EXPOSURE TO ATRAZINE AND GLYPHOSATE THROUGHOUT INCUBATION ON BONE DEVELOPMENT OF PODOCNEMIS EXPANSA (TESTUDINES, PODOCNEMIDIDAE)

Brazil is considered to be one of the largest consumers of pesticides in the world, and herbicides represent the most commonly used class of these products. Atrazine and glyphosate, the most important herbicides, contaminate the waters of several Brazilian rivers and are involved in organ and bone malformations in different species. Among the possible target organisms, reptiles may be indirectly affected by pesticide use once their natural habitats are rivers and streams. Therefore, the objective of this study was to assess the possible effects of exposure to the herbicides atrazine and glyphosate in bone ontogeny of Podocnemis expansa. Eggs were artificially incubated in sand moistened with water contaminated with atrazine at concentrations equal to 0, 2, 20, or 200 μg/L, and glyphosate at 65, 650 or 6,500 μg/L. In the control group, the substrate was moistened with distilled water. Two eggs were collected from each incubator every ten days until hatching. For the analysis of bone development, soft tissues were diaphanized, and bones and cartilages were stained with Alizarin red S and Alcian blue, respectively. Specimens were analyzed by stereomicroscopy. Morphological characteristics of the cartilages and bones of the embryos were compared with descriptions of normal ontogeny available in the literature for P. expansa embryos. No abnormalities were observed in bone ontogeny of any of the experimental groups.
Predicting volleyball serve-reception at group level

ABSTRACT In a group-serve-reception task, how does serve-reception become effective? We addressed “who” receives/passes the ball, what task-related variables predict action mode selection and whether the action mode selected was associated with reception efficacy. In 182 serve-receptions we tracked the ball and the receivers’ heads with two video-cameras to generate 3D world-coordinates reconstructions. We defined receivers’ reception-areas based on Voronoi diagrams (VD). Our analyses of the data showed that this approach was accurate in describing “who” receives the serve in 95.05% of the times. To predict action mode selection, we used variables related to: serve kinematics, receiver’s movement and on-court positioning, the relation between receiver and his closest partner, and interactions between receiver-ball and receiver-target. Serve’s higher initial velocities together with higher maximum height, as well as smaller longitudinal distances between receiver and target increased the chances for the use of the overhand pass. Conversely, decreasing alignment of the receiver with the ball and the target increased the chances of using the underhand-lateral pass. Finally, the use of the underhand-lateral pass was associated with lower quality receptions. Behavioural variability’s relevance for serve-reception training is discussed.
Psychology, Law, and the Wellbeing of Children

Series Foreword Acknowledgments About the Editors Contributors 1. Psychology, law, and the wellbeing of children: An overview Monica K. Miller and Jared C. Chamberlain 2. Psychology, Law, and the Wellbeing of Children: A Developmental Perspective Twila Wingrove and Sarah J. Beal Part I: Legal Actions Affecting the Wellbeing and Recognizing (or Ignoring) the Developmental Abilities of Juvenile Delinquents 3. Psycho-Legal Aspects of Juvenile Delinquency Cheryl D. Wills 4. Police Interviewing and Interrogation of Adolescent Suspects: Process and Outcomes Hayley M.D. Cleary and Sarah Vidal 5. Applying Sex Offender Registry Laws to Juvenile Offenders: Biases against Stigmatized Youth Jessica M. Salerno, Margaret Stevenson, Cynthia J. Najdowski, Tisha R.A. Wiley, Bette L. Bottoms, and Liana Peter-Hagene 6. Female Juvenile Offenders' Perceptions of Gender-Specific Programs Monica K. Miller, Lacey Miller, and Angela D. Broadus 7. Balancing Legal, Ethical, and Clinical Considerations when Managing Suicidality in Research with Juvenile Justice Involved Youth Christy L. Giallella, Naomi E. S. Goldstein, and David DeMatteo Part II: Legal actions affecting the wellbeing of children experiencing parental divorce 8. Hearing the Voice of the Child in Divorce Robin H. Ballard, Brittany N. Rudd, Amy G. Applegate, and Amy Holtzworth-Munroe 9. Establishing Child Support and Visitation Enforcement Offices: Promoting Fairness, Compliance, and Children's Wellbeing Monica K. Miller and Jon Maskaly 10. Parental Alienation and the Best Interests of the Child R. Brian Howe and Katherine Covell Part III: Legal actions affecting the wellbeing of children 11. The Search for Therapeutic Solutions to Maternal Incarceration: Promoting the Wellbeing of Children Monica K. Miller and Lacey Miller 12. Immigrant Parents' Perceptions of the " Qingwen Xu 13. Assessment of Mock Jurors' Attributions and Decisions in Child Abuse Cases: Protecting the Wellbeing of Obese Children Jenny Reichert and Monica K. Miller 14. A Preliminary Analysis of Public Commentary Supporting and Opposing Mandatory HPV Vaccination: Implications for Policy Lorie L. Sicafuse and Monica K. Miller 15. The Law and Child Wellbeing: Where are We and Where Do We Go From Here? Twila Wingrove and Jennifer L. Jarrett Index
Pharmacological treatment of sexual offenders in German outpatient treatment centers

In Germany, depending on a sexual offender’s culpability and the severity of the offence, he/she can be placed either in the forensic-psychiatric or the correctional system. Numbers related to the pharmacological treatment of sexual offenders for the correctional system are missing so far. In sexual offenders, the pharmacological treatment of paraphilic disorders is of special importance. The present study aimed at assessing the prevalence of pharmacological sexual offender treatment in German outpatient treatment centers supervising mainly clients from the correctional sector. An online questionnaire was sent to 112 outpatient treatment centers and 21 provided data relevant for the present study. The included institutions reported about a total of 813 sexual offenders, of whom 200 (24.6%) were treated with pharmacological agents, most frequently antipsychotics (14.8%) and selective-serotonin-reuptake-inhibitors (7.1%). Of the total sample, 26.7% of sexual offenders were diagnosed with a paraphilic – mainly with a pedophilic – disorder. Only 2% were treated with androgen-deprivation therapy. Compared with forensic-psychiatric institutions, only a minority of sexual offenders are treated with medication specifically addressing paraphilic symptomatology. However, the prevalence of paraphilic disorders found in the present study suggests that pharmacological treatment of paraphilic fantasies and behaviors could be of great importance in the correctional sector as well.
Leptin and Prolactin, but not Corticosterone, Modulate Body Weight and Thyroid Function in Protein-malnourished Lactating Rats

To understand the role of hormonal changes in the lower food ingestion and body weight in protein-restricted lactating rats as well as the higher serum T (3), higher deiodination, iodide and T (3) milk transfer, we measured maternal serum prolactin, leptin, TSH and corticosterone, which are hormones that could influence those parameters. After birth, dams were separated into: control-fed with a 23 % protein diet (n = 12) and PR (protein-restricted)-fed with an 8 % protein diet (n = 12). At the 4 (th) and 21 (st) day of lactation, half of the animals in each group were sacrificed. PR dams presented hyperleptinemia (day 4: + 20 %; day 21: + 19 %; p < 0.05) and hypoprolactinemia (day 4: - 85 %; day 21: - 92 %; p < 0.05), which could help explain the lower food consumption and body weight in lactating PR rats since leptin is anorexigenic and prolactin is orexigenic. Also, this hyperleptinemia could contribute for the increase in serum T (3) of PR dams, since leptin stimulates T (3) production, especially acting on deiodinases. Serum corticosterone was not different between PR and C groups, and TSH was lower only at the end of lactation. Thus, we suggest that both leptin and prolactin could play an important role in the body weight and thyroid hormone changes observed in protein-malnourished lactating rats.
Poaching Detection Technologies—A Survey

Between 1960 and 1990, 95% of the black rhino population in the world was killed. In South Africa, a rhino was killed every 8 h for its horn throughout 2016. Wild animals, rhinos and elephants, in particular, are facing an ever increasing poaching crisis. In this paper, we review poaching detection technologies that aim to save endangered species from extinction. We present requirements for effective poacher detection and identify research challenges through the survey. We describe poaching detection technologies in four domains: perimeter based, ground based, aerial based, and animal tagging based technologies. Moreover, we discuss the different types of sensor technologies that are used in intruder detection systems such as: radar, magnetic, acoustic, optic, infrared and thermal, radio frequency, motion, seismic, chemical, and animal sentinels. The ultimate long-term solution for the poaching crisis is to remove the drivers of demand by educating people in demanding countries and raising awareness of the poaching crisis. Until prevention of poaching takes effect, there will be a continuous urgent need for new (combined) approaches that take up the research challenges and provide better protection against poaching in wildlife areas.
Fn3 proteins engineered to recognize tumor biomarker mesothelin internalize upon binding

Mesothelin is a cell surface protein that is overexpressed in numerous cancers, including breast, ovarian, lung, liver, and pancreatic tumors. Aberrant expression of mesothelin has been shown to promote tumor progression and metastasis through interaction with established tumor biomarker CA125. Therefore, molecules that specifically bind to mesothelin have potential therapeutic and diagnostic applications. However, no mesothelin-targeting molecules are currently approved for routine clinical use. While antibodies that target mesothelin are in development, some clinical applications may require a targeting molecule with an alternative protein fold. For example, non-antibody proteins are more suitable for molecular imaging and may facilitate diverse chemical conjugation strategies to create drug delivery complexes. In this work, we engineered variants of the fibronectin type III domain (Fn3) non-antibody protein scaffold to bind to mesothelin with high affinity, using directed evolution and yeast surface display. Lead engineered Fn3 variants were solubly produced and purified from bacterial culture at high yield. Upon specific binding to mesothelin on human cancer cell lines, the engineered Fn3 proteins internalized and co-localized to early endosomes. To our knowledge, this is the first report of non-antibody proteins engineered to bind mesothelin. The results validate that non-antibody proteins can be engineered to bind to tumor biomarker mesothelin, and encourage the continued development of engineered variants for applications such as targeted diagnostics and therapeutics.
BEOL compatible (300°C) TiN/TiOx/Ta/TiN 3D nanoscale (∼10nm) IMT selector

TiOx based Insulator-Metal-Transition (IMT) devices with TiN electrode were investigated for selector application. To maximize heat confinement, we adopted localized filament by breaking stoichiometric ALD TiO2 layer. Using Ti4O7 target and reduction annealing with Ta electrode, IMT layer was formed. By optimizing device structure to maximize heat confinement and oxygen stoichiometry to obtain IMT Ti3O5 layer, we could maximize IMT characteristics at low threshold power. Scaling device area significantly improves the IMT characteristics. Moreover, reliable 1S1R characteristics were also confirmed.
Dynamics of nanoparticle morphology under low energy ion irradiation

If nanostructures are irradiated with energetic ions, the mechanism of sputtering becomes important when the ion range matches about the size of the nanoparticle. Gold nanoparticles with diameters of ∼50 nm on top of silicon substrates with a native oxide layer were irradiated by gallium ions with energies ranging from 1 to 30 keV in a focused ion beam system. High resolution in situ scanning electron microscopy imaging permits detailed insights in the dynamics of the morphology change and sputter yield. Compared to bulk-like structures or thin films, a pronounced shaping and enhanced sputtering in the nanostructures occurs, which enables a specific shaping of these structures using ion beams. This effect depends on the ratio of nanoparticle size and ion energy. In the investigated energy regime, the sputter yield increases at increasing ion energy and shows a distinct dependence on the nanoparticle size. The experimental findings are directly compared to Monte Carlo simulations obtained from iradina and TRI3DYN, where the latter takes into account dynamic morphological and compositional changes of the target.
Psychiatric diagnoses of children affected by their parents’ traumatic brain injury: the 1987 Finnish Birth Cohort study

ABSTRACT Objective: To investigate whether parental TBI increases the overall risk for psychiatric disorders and the risk for specific psychiatric diagnoses in the children affected by parental TBI. Methods: The 1987 Finnish Birth Cohort (n = 59 476) were followed up through national registers from birth to the end of 2008. The diagnoses of cohort members and their parents were obtained from the Care Register of Health Care, provided by the National Institute of Health and Welfare. Results: During the 21-year follow-up, the likelihood for psychiatric diagnoses being assessed in psychiatric care was significantly increased in males with any mental disorder (odds ratio (OR) = 1.43), substance-use-related disorders (OR = 1.71) and behavioural and emotional disorders (OR = 1.75), and in females with disorders of psychological development (OR = 1.85). Conclusions: Children affected by parental TBI are at increased risk for psychiatric disorders: males for externalizing disorders and females for developmental disorders. Observed gender interactions in the association between parental TBI and the psychiatric disorders of children warrant further study.
Rituximab plus bendamustine as front-line treatment in frail elderly (>70 years) patients with diffuse large B-cell non-Hodgkin lymphoma: a phase II multicenter study of the Fondazione Italiana Linfomi

We conducted a phase II study to assess activity and safety profile of bendamustine and rituximab in elderly patients with untreated diffuse large B-cell lymphoma (DLBCL) who were prospectively defined as frail using a simplified version of the Comprehensive Geriatric Assessment (CGA). Patients had to be over 70 years of age, with histologically confirmed DLBCL. Frail patients were those younger than 80 years with a frail profile at CGA or older than 80 years with an unfit profile. Treatment consisted of 4-6 courses of bendamustine [90 mg/m2 days (d)1-2] and rituximab (375 mg/m2 d1) administered every 28 days. Other main study end points were complete remission rate and the rate of extra-hematologic adverse events. Forty-nine patients were enrolled of whom 45 were confirmed eligible. Overall, 24 patients achieved a complete remission (53%; 95%CI: 38-68%) and the overall response rate was 62% (95%CI: 47-76%). The most frequent grade 3-4 adverse event was neutropenia (37.8%). Grade 3-4 extra-hematologic adverse events were observed in 7 patients (15.6%; 95%CI: 6.5-29.5%); the most frequent was grade 3 infection in 2 patients. With a median follow up of 33 months (range 1-52), the median progression-free survival was ten months (95%CI: 7-25). The study shows promising activity and manageable toxicity profile of BR combination as first-line therapy for patients with DLBCL who are prospectively defined as frail according to a simplified CGA, as adopted in this trial (clinicaltrials.gov identifier: 01990144).
Spinosad: A biorational mosquito larvicide for vector control

© 2018 Indian Journal of Medical Research, published by Wolters Kluwer Medknow for Director-General, Indian Council of Medical Research Vector-borne diseases are among the extensive causes of illness throughout the tropics and to some extent in subtropics. Globally, vector-borne diseases account for >17 per cent of all infectious diseases that cause >1 million deaths annually and >2.5 billion people are at risk of vector-borne diseases1. Vector control is one of the essential components for vector-borne disease management. Currently, there are four classes of insecticides recommended by the WHO for indoor residual spray for vector control, namely, organochlorines, organophosphates, carbamates and pyrethroids; and larvicides include bacterial pesticides, benzoylureas, juvenile hormone mimics, organophosphates and spinosyns while only one class i.e. synthetic pyrethroids is recommended for insecticide treated nets (ITNs).
Caught flat-footed: podocyte damage and the molecular bases of focal glomerulosclerosis.

The renal glomerulus, the site of plasma ultrafiltration and the production of primary urine (1), is the locus of a number of progressive disorders that lead to chronic renal insufficiency. Before the advent of renal replacement therapies, these diseases invariably led to death by uremia. Still, while these treatments save, or at least extend, patient’s lives, they do so at an enormous price, both in human and financial terms.
The influence of incidental and integral affects on outgroup perception

Une etude experimentale a ete concue pour analyser l'influence d'humeurs emotionnelles integrales et incidentes sur les stereotypes. Cette etude analyse l'influence des etats de colere et de tristesse, induits de maniere incidente ou integrale sur des stereotypes lies a un hors-groupe (des etudiants ingenieurs). Les resultats montrent que l'humeur a une influence significative sur la perception du hors-groupe dans la condition integrale, mais pas dans la condition incidente. L'hypothese de l'interaction entre humeur et methodes d'induction a pu etre confirmee. L'hypothese d'un effet principal de l'humeur sur la perception (perception plus stereotypee liee a la colere et moins stereotypee dans la condition de tristesse en comparaison avec la condition neutre) a recu un appui partiel et contradictoire. Ces resultats, partiellement contradictoires, peuvent en partie etre expliques par les methodes utilisees pour l'induction des humeurs.
Packing Directed Circuits through Prescribed Vertices Bounded Fractionally

A seminal result of Reed et al. [Combinatorica, 16 (1996), pp. 535--554] says that a directed graph has either $k$ vertex-disjoint directed circuits or a set of at most $f(k)$ vertices meeting all directed circuits. This paper aims at generalizing their result to packing directed circuits through a prescribed set $S$ of vertices. Such a circuit is called an $S$-circuit. Even et al. [Algorithmica, 20 (1998), pp. 151--174] showed a fractional version of packing $S$-circuits. In this paper, we show that the fractionality can be bounded by at most one-fifth: Given an integer $k$ and a vertex subset $S$, whose size may not depend on $k$, we prove that either $G$ has a $1/5$-integral packing of $k$ disjoint $S$-circuits, i.e., each vertex appears in at most five of these $S$-circuits, or $G$ has a vertex set $X$ of order at most $f(k)$ (for some function $f$ of $k$) such that $G-X$ has no such circuit. We also give a fixed-parameter tractable approximation algorithm for finding a $1/5$-integral packing of $S$-c.