Miracle-dz/UniFAR-FTUs huggingface dataset:
Infliximab dosing patterns in a sample of patients with Crohn's disease: results from a medical chart review.

BACKGROUND Infliximab, a monoclonal antibody tumor necrosis factor-alpha inhibitor, is an effective therapy that is indicated for the treatment of patients with Crohn's disease. Although dose escalation from 5 mg/kg to 10 mg/kg is allowed according to the prescribing label of infliximab, conflicting results exist regarding the rate at which this escalation may occur, which may affect payers and providers. OBJECTIVE The goal of this exploratory study was to characterize and quantify the rate of infliximab dose escalation in a sample of patients with Crohn's disease. METHODS Administrative claims data from patients with Crohn's disease in a large mid-Atlantic managed care organization were collected and used to target and recruit providers into a chart review study of infliximab dosing. Data from the charts of 161 patients with Crohn's disease who were receiving infliximab between 2006 and 2010 were extracted. Patients were grouped into an infliximab dose-escalation group or a dose-stable group based on these data. The evidence of any infliximab dose ≥7.5 mg/kg or evidence of a mean maintenance interval of 42 days or less resulted in the placement of a patient in the dose-escalation group, with the balance of patients comprising the stable-dose group. RESULTS A total of 925 infliximab infusions were captured from 161 patients. Of the 161 patients identified, 110 had at least 4 infusions, and 4 had missing data; therefore, only 106 (66%) patients were qualified for the final infliximab dosing analysis. A total of 18 (17%) of these patients had evidence of infliximab dose escalation (dose-escalation group), and the remaining 88 (83%) patients had a consistent 5-mg/kg dose and schedule (stable-dose group). Of the 18 patients in the dose-escalation group, 9 (50%) had a decrease in maintenance interval, whereas 12 (66.7%) patients had an increase in their dosage. A total of 3 (16.7%) patients had both an increase in dose and a reduction in maintenance interval. CONCLUSIONS Infliximab has been shown to be a cost-effective treatment for patients with Crohn's disease. The rate of infliximab dose escalation in this study was within the lower range of published estimates for this medication. Studies using larger sample sizes are needed to validate the findings of the current study. In addition, studies that are focused on quantifying and describing the nature of infliximab dose escalation may be useful in the development of successful patient-treatment matching algorithms.
FAT TREE BASED CROSSTALK ANALYSIS IN OPTICAL NETWORKS

Fat tree based Networks on chip (NoC) have the potential of higher bandwidth and efficient power consumption which is better suitable for electronic Networks on Chip. The key components of optical network on chips are optical devices which experience crosstalk noise and power loss that in turn reduces the network scalability. The 3D based Network on Chip (NoC) architectures represent a promising design paradigm to cope with increasing communication requirements in digital systems. 3D Network on chip (NoC) has emerged as a vital factor that determines the performance and power consumption of many core systems. A novel switching mechanism, called virtual circuit switching, is implemented with circuit switching and packet switching. A path allocation algorithm is used to determine high priority based adaptive circuit switching connections and circuitswitched connections on a Fat-Tree-connected 3D-NoC such that both communication latency and power are optimized. The goal of this paper is to investigate the runtime adaptation of the 3D-NoC resources, according to the QoS requirements of each application running in the MPSoC. This paper adopts an NoC architecture with duplicated physical channels, adaptive routing, support to flow priorities and simultaneous packet and circuit switching. This work is to analyse the destination position level for 3D-layer based hierarchal NOC structure and to select the path using circuit switching technique. This process is to optimize the overall 3D-NOC architecture complexity level and to reduce the path delay time and clock latency time compare to existing methodology.
Probabilistic Reverse Nearest Neighbor Queries on Uncertain Data

Uncertain data are inherent in various important applications and reverse nearest neighbor (RNN) query is an important query type for many applications. While many different types of queries have been studied on uncertain data, there is no previous work on answering RNN queries on uncertain data. In this paper, we formalize probabilistic reverse nearest neighbor query that is to retrieve the objects from the uncertain data that have higher probability than a given threshold to be the RNN of an uncertain query object. We develop an efficient algorithm based on various novel pruning approaches that solves the probabilistic RNN queries on multidimensional uncertain data. The experimental results demonstrate that our algorithm is even more efficient than a sampling-based approximate algorithm for most of the cases and is highly scalable.
Factors associated with non-utilisation of postnatal care services in Indonesia

Background: Postnatal care helps prevent neonatal deaths. This study aims to examine factors associated with non-utilisation of postnatal care in Indonesia. Methods: A cross-sectional analytic study was conducted using data from the 2002–3 Indonesia Demographic and Health Survey (IDHS), which used multistage cluster random sampling. Contingency table and logistic regression analyses were used to determine the factors associated with non-utilisation of postnatal care services. The population attribution risk percentage (PAR%) for non-utilisation of postnatal care services was also calculated. Results: Data were available for 15 553 singleton live-born infants. The prevalence of non-attendance at postnatal care services was consistently higher in rural areas than in urban areas. Maternal factors associated with lack of postnatal care included low household wealth index, low education levels, lack of knowledge of pregnancy-related complications or where distance from health services was a problem. Infants of high birth rank and those reported to be smaller than average were less likely to receive postnatal care. Other indicators of access to healthcare services which were associated with non-utilisation of postnatal care services included few antenatal care checks, use of untrained birth attendants and births outside healthcare facilities. Conclusion: Public health interventions to increase the utilisation of postnatal care services should target women who are poor, less educated, from rural areas and who use untrained birth attendants. Strategies to improve the availability and accessibility of antenatal care services and skilled birth attendance including focused financial support and health promotion programmes, particularly in the rural areas, should increase utilisation of postnatal care services in Indonesia.
Factors Influencing Intention of Citizens to Spread Information over Mobile Phones: Implications for Mobile Governance in India

Citizens' act of spreading of information, also known as electronic word-of-mouth (eWOM), enables governments to effectively engage with citizens over information and communication technologies (ICTs). This poster explores the factors that influence the intention of citizens to spread information in mobile communication. Qualitative and quantitative responses collected via an online survey from 97 graduate students at the Central University of Gujarat, India, suggest that: (a) the type of online communication channel available for the message to be forwarded, (b) content of the message, (c) likeability of the message, (d) priority of the activity students are engaged in over the message to be forwarded, and (e) if the message is related to any emergency situation, are the top five factors influencing students' intention to forward messages over their mobile phones. Theoretical and practical implications of this study for effective civic engagement in mobile governance are discussed at the end.
Overnight versus 24 Hours of Continuous Subcutaneous Insulin Infusion as Supplement to Oral Antidiabetic Drugs in Type 2 Diabetes

Background: Basal continuous subcutaneous insulin infusion (CSII) therapy at a fixed rate may effectively improve glycemic control in patients with type 2 diabetes when oral antidiabetic treatment fails. Regimens of simple constant subcutaneous delivery of insulin may provide theoretical advantages in type 2 diabetes. Methods: Ten subjects with type 2 diabetes who obtained insufficient glycemic control on oral antidiabetic drugs were included. Following an initial control day, two periods of 3 days with CSII of a rapid-acting insulin analogue, 1.5 IU/h (dose obtained from a preceding study), for 8 hours overnight and for 24 hours, respectively, were carried out in random order. Profiles of serum insulin aspart, serum endogenous insulin, and plasma glucose were recorded. Results: Compared to the control day, an 8-hour overnight insulin infusion during a 3-day period improved fasting plasma glucose (FPG) (mean differences ± SEM; Δ59.0 ± 10.1 mg/dl; p < 0.01) and 2-hour postprandial plasma glucose (PPPG) (Δ57.8 ± 10.6 mg/dl; p < 0.01) after breakfast. Compared to an 8-hour overnight infusion, a 24-hour infusion further improved all three PPPG values after breakfast, lunch, and dinner (Δ28.8 ± 8.1 mg/dl, Δ30.6 ± 8.1 mg/dl, and Δ35.1 ± 7.9 mg/dl; p < 0.01). During insulin infusion, only one hypoglycemic episode with PG <55.8 mg/dl and mild symptoms was recorded. Conclusion: Continuous subcutaneous insulin infusion with a rapid-acting insulin analogue at a fixed rate of 1.5 IU/h, either overnight or for 24 hours, improved glycemic control without safety concerns in patients with type 2 diabetes who had secondary failure to oral antidiabetic drugs. The effect on FPG was similar for both treatments, whereas the effect on PPPG was superior when insulin was infused during the entire 24 hours.
Pathophysiology of Campylobacter enteritis.

Abstract : Campylobacter jejuni has exploded from obscurity to be recognized as a major human enteric pathogen. This recognition has triggered numerous bacteriological investigations, but the many mysteries and surprises associated with the organism will challenge the creative efforts of scientists for years to come. This reprint discusses the pathophysiology of the enter-opathogen. Reprints.
Montclair State University Digital Montclair State University Digital

— The term brain based is often used to describe learning theories, principles, and products. Although there have been calls urging educators to be cautious in interpreting and using such material, consumers may ﬁnd it challenging to understand the role of the brain and to discriminate among brain based products to determine which would be suitable for speciﬁc educational goals. We offer a framework for differentiating the multiple meanings of the brain based label and guidelines for educators and consumers to use when evaluating educational products labeled as brain based. The guidelines include: identifying educational goals and target student populations, aligning goals and product purposes, reviewing product merits, identifying beneﬁts and limitations of the product, and characterizing the product’s impact on behavioral performance.
Regulation of the DNA damage response by ubiquitin conjugation

In response to DNA damage, cells activate a highly conserved and complex kinase-based signaling network, commonly referred to as the DNA damage response (DDR), to safeguard genomic integrity. The DDR consists of a set of tightly regulated events, including detection of DNA damage, accumulation of DNA repair factors at the site of damage, and finally physical repair of the lesion. Upon overwhelming damage the DDR provokes detrimental cellular actions by involving the apoptotic machinery and inducing a coordinated demise of the damaged cells (DNA damage-induced apoptosis, DDIA). These diverse actions involve transcriptional activation of several genes that govern the DDR. Moreover, recent observations highlighted the role of ubiquitylation in orchestrating the DDR, providing a dynamic cellular regulatory circuit helping to guarantee genomic stability and cellular homeostasis (Popovic et al., 2014). One of the hallmarks of human cancer is genomic instability (Hanahan and Weinberg, 2011). Not surprisingly, deregulation of the DDR can lead to human diseases, including cancer, and can induce resistance to genotoxic anti-cancer therapy (Lord and Ashworth, 2012). Here, we summarize the role of ubiquitin-signaling in the DDR with special emphasis on its role in cancer and highlight the therapeutic value of the ubiquitin-conjugation machinery as a target in anti-cancer treatment strategy.
Effect of aqueous extract of Leonotis leonurus (L.) R. Br. leaves in male Wistar rats

The aqueous extract of the leaves of Leonotis leonurus (L.) R. Br. at the doses of 125, 250 and 500 mg/kg body weight was investigated for toxicity in male rats following administration on daily basis for 21 days. The extract did not significantly (p > .05) alter the levels of haemoglobin, packed cell volume, mean corpuscular volume, red cell distribution width, basophils, total protein, phosphorus, calcium and chloride ions of the animals. Whereas the levels of lymphocytes, eosinophils, monocytes, triacylglycerol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, atherogenic index, albumin as well as alkaline phosphatase and gamma glutamyl transferase activity were decreased by the extract, those of neutrophil, magnesium, total and conjugated bilirubin, alanine and aspartate aminotransferase as well as liver and kidney body weight ratios increased. There was decrease in the mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration and cholesterol only at the 500 mg/kg body weight of the extract, whereas the large unstained cells, sodium ions, white blood cells and uric acid increased only at 250 and 500 mg/kg body weight of the extract, respectively. The urea, creatinine and potassium increased only at 125 mg/kg body weight of the extract while the globulin content was elevated only at 500 mg/kg body weight of the extract. The doses did not produce any definite pattern of effect on the red blood cells and platelets. These alterations by the aqueous extract of L. leonurus leaves on the haematological together with the liver and kidney functional indices suggests parameter and dose-selective effects of the extract and will have consequential effects on the normal functioning of the blood system, kidney and liver of the animals. The extract is also unlikely to predispose the animals to cardiovascular risk when repeatedly consumed on daily basis at the doses investigated for 21 days. Therefore, the aqueous extract of L. leonurus leaves may not be ‘safe’ as oral remedy in male rats.
Inferring extinction in North American and Hawaiian birds in the presence of sighting uncertainty

For most species the timing of extinction events is uncertain, occurring sometime after the last sighting. However, the sightings themselves may also be uncertain. Recently a number of methods have been developed that incorporate sighting uncertainty in the inference of extinction based on a series of sightings. Here we estimate the timing of extinction for 41 of 52 North American and Hawaiian bird taxa and populations, the results of which suggest all became extinct before 2009. By acknowledging sighting uncertainty it results in two opposite effects, one pushing the timing of extinction away from the last sighting and the other drawing the timing of extinction nearer to it. However, for 14 assessed taxa and populations the upper 95% bounds lie beyond the end of the observation period and therefore suggest the possibility of continued persistence. This has important implications for conservation decision-makers and potentially reduces the likelihood of Romeo’s Error.
Indirect selection of thermal tolerance during experimental evolution of Drosophila melanogaster

Natural selection alters the distribution of a trait in a population and indirectly alters the distribution of genetically correlated traits. Long-standing models of thermal adaptation assume that trade-offs exist between fitness at different temperatures; however, experimental evolution often fails to reveal such trade-offs. Here, we show that adaptation to benign temperatures in experimental populations of Drosophila melanogaster resulted in correlated responses at the boundaries of the thermal niche. Specifically, adaptation to fluctuating temperatures (16–25°C) decreased tolerance of extreme heat. Surprisingly, flies adapted to a constant temperature of 25°C had greater cold tolerance than did flies adapted to other thermal conditions, including a constant temperature of 16°C. As our populations were never exposed to extreme temperatures during selection, divergence of thermal tolerance likely reflects indirect selection of standing genetic variation via linkage or pleiotropy. We found no relationship between heat and cold tolerances in these populations. Our results show that the thermal niche evolves by direct and indirect selection, in ways that are more complicated than assumed by theoretical models.
Nucleosomes are major T and B cell autoantigens in systemic lupus erythematosus.

OBJECTIVE Double-stranded DNA (dsDNA) is a well-known target of autoantibodies in systemic lupus erythematosus (SLE). The majority of these autoantibodies are of the IgG isotype and show affinity maturation, both of which are known hallmarks of T cell help. T cell responses to autoantigens, including DNA, have been reported only incidentally in SLE patients. Nevertheless, in murine SLE, naked DNA and complexed DNA (nucleosomes) are known to be recognized by T cells. This study aimed to characterize the antinucleosome response and its clinical impact on human SLE. METHODS Nucleosomes were prepared from chicken erythrocytes. Sera from SLE and control patients were investigated by enzyme-linked immunosorbent assay (ELISA) for nucleosome-specific antibody responses. Peripheral blood mononuclear cells (PBMC) from SLE and control patients were analyzed by a kinetic T cell proliferation assay. PBMC were subsequently analyzed for nucleosome-specific T cell proliferation. RESULTS Of 136 SLE patients, 56% were seropositive for antinucleosome antibodies. In contrast, only 3% of 309 control patients (with rheumatoid arthritis, mixed connective tissue disease, undifferentiated connective tissue disease, Lyme borreliosis, scleroderma, Sjögren's syndrome, ulcerative colitis, hepatitis B virus infection, or human immunodeficiency virus infection) were seropositive. Thus, the antinucleosome ELISA had a sensitivity of 56%, a specificity of 97%, and a diagnostic confidence of 90% when applied to SLE. It was therefore superior to an anti-DNA ELISA that demonstrated a 69% diagnostic confidence in the same population. Antinucleosome reactivity in SLE patients correlated significantly with disease activity (P < 0.0001), nephritis (P < 0.002), and psychosis (P < 0.02). When proliferation assays were applied, 14 of 26 SLE patients (54%) were positive for nucleosome-specific T cells that proliferated in response to their cognate antigen. A suppressed response was elicited in 3 SLE patients (12%); in these patients, the PBMC response to nucleosomes was lower than the proliferation of PBMC in the presence of culture medium only. PBMC from the remaining 9 SLE patients (35%) were nonresponsive to nucleosomes in either way. Responding, nonresponding, and suppressed populations differed from each other significantly (P < 0.0001). None of the PBMC from 7 healthy donors and 10 control patients could be stimulated with nucleosomal antigens. CONCLUSION We present evidence that nucleosomes are major autoantigens in human SLE and that antinucleosomal antibodies are highly specific for the disease. The antinucleosome ELISA has been shown to be superior to the anti-dsDNA ELISA and may thus be a significantly better tool for diagnosing SLE. Nucleosome-specific T cells in SLE patients may help B cells class switch to IgG and undergo affinity maturation.
Integrative and conjugative elements and their hosts: composition, distribution and organization

Conjugation of single-stranded DNA drives horizontal gene transfer between bacteria and was widely studied in conjugative plasmids. The organization and function of integrative and conjugative elements (ICE), even if they are more abundant, was only studied in a few model systems. Comparative genomics of ICE has been precluded by the difficulty in finding and delimiting these elements. Here, we present the results of a method that circumvents these problems by requiring only the identification of the conjugation genes and the species’ pan-genome. We delimited 200 ICEs and this allowed the first large-scale characterization of these elements. We quantified the presence in ICEs of a wide set of functions associated with the biology of mobile genetic elements, including some that are typically associated with plasmids, such as partition and replication. Protein sequence similarity networks and phylogenetic analyses show that ICEs are modular and that their gene repertoires can be grouped in function of their conjugation types, even if integrases were shown to be paraphyletic relative to the latter. We show that there are general trends in the functional organization of genes within ICEs and of ICEs within the bacterial chromosome paving the way for future functional and evolutionary analyses.
Performance evaluation method for use in karaoke apparatus

A method for measuring by a difference between the vocal sound karaoke musical accompaniment OK singer with a sound image generated by the device and method of evaluation Evaluation sing sung by the karaoke singer's OK OK in the karaoke apparatus. By simultaneously sampling singing voice Kara OK singer with musical accompaniment, respectively. Generating digitized audio signal and their corresponding digital accompaniment signal. Then, the difference and the difference between the trend of a digitized audio signal corresponding digital accompaniment signal, and for generating a singing score.
FailSafe: A generalized methodology for converter fault detection, identification, and remediation in nanogrids

We present the design, implementation, and experimental validation of FailSafe - a generalized methodology for fault detection, identification, and remediation (FDIR) for switching power converters in nanogrids. FailSafe is a dynamical systems approach to FDIR for switching power converters, and can be applied to a broad class of converters and fault types. FailSafe operates as part of the control loop of a switching power converter, and uses the measurements and inputs of the converter to achieve both fault detection and identification (FDI) and fault remediation. In this paper, we present two Modules for FDI - a model-based residual approach and a data-driven multiclass Support Vector Machine (one-vs-one) approach. Moreover, we describe the design of a fault remediation Module by designing optimal control actions in a pre-computed reach-avoid set. We present simulation and experimental results using a prototype nanogrid testbed. Simulation results for the multiclass Support Vector Machine (one-vs-one) FDI Module on a 6-phase interleaved boost converter demonstrate fault detection and identification with a classification accuracy of 98.9% for a current sensor fault and 90.8% for an output capacitor fault. Experimental results for the model-based residual FDI Module on a boost converter demonstrate fault detection and identification in 600 μs for a capacitor fault and 250 μs for a voltage sensor fault.