Miracle-dz/UniFAR-FTUs huggingface dataset:
Patient Smartphone Ownership and Interest in Mobile Apps to Monitor Symptoms of Mental Health Conditions: A Survey in Four Geographically Distinct Psychiatric Clinics

Background Despite growing interest in mobile mental health and utilization of smartphone technology to monitor psychiatric symptoms, there remains a lack of knowledge both regarding patient ownership of smartphones and their interest in using such to monitor their mental health. Objective To provide data on psychiatric outpatients’ prevalence of smartphone ownership and interest in using their smartphones to run applications to monitor their mental health. Methods We surveyed 320 psychiatric outpatients from four clinics around the United States in order to capture a geographically and socioeconomically diverse patient population. These comprised a state clinic in Massachusetts (n=108), a county clinic in California (n=56), a hybrid public and private clinic in Louisiana (n=50), and a private/university clinic in Wisconsin (n=106). Results Smartphone ownership and interest in utilizing such to monitor mental health varied by both clinic type and age with overall ownership of 62.5% (200/320), which is slightly higher than the average United States’ rate of ownership of 58% in January 2014. Overall patient interest in utilizing smartphones to monitor symptoms was 70.6% (226/320). Conclusions These results suggest that psychiatric outpatients are interested in using their smartphones to monitor their mental health and own the smartphones capable of running mental healthcare related mobile applications.
International accounting harmonization

This article will show that international accounting harmonization is predominantly harmonization with the Anglo-Saxon accounting model and [disregards] the economic, social and cultural environment of other accounting systems. It intends to show that in France international harmonization has broken down the homogeneity of the accounting model. This process has resulted in a reduction of the social functions of accounting. Finally, it seeks to suggest an approach towards harmonization that will be more respectful of different identities: the mutual recognition of accounting standards with benchmarks. This new approach would consist of developing a set of international accounting rules that would prescribe a single accounting treatment for each issue covered, but which at the same time would allow companies in each country the choice of publishing financial statements drawn up according to national rules,subject to enclosing the reconciliation schedules with international standards. This approach would enable companies to comply with their own national rules while at the same time ensuring the comparability of their financial statements at an international level.
General Circulatory Alterations Induced by Intravenous Infusion of Synthetic Bradykinin in Man

The general hemodynamic effects induced by a continuous intravenous infusion of syntheticbradykinin were studied in ten patients submitted to simultaneous right- and left-heart catheterization. A significant drop in systemic arterial pressure and in total peripheral resistance was observed, coincident with an increase of the cardiac output, heart rate, and stroke volume. There was no consistent change of the pulmonary arterial and left atrial pressures, but the pulmonary vascular resistance decreased significantly.
Indicators of need for mechanical ventilation in Duchenne muscular dystrophy and spinal muscular atrophy.

STUDY OBJECTIVES The purpose was to investigate a possible relationship between different parameters of physical function, spirometric measurements, and the approaching need for mechanical ventilation. DESIGN A nonrandomized, prospective, descriptive study of 11 patients with spinal muscular atrophy type II (SMA-II) and 14 patients with Duchenne muscular dystrophy (DMD). At a home visit, the anthropometric indices of age, height, and weight were recorded, the degree of disability was scored, and measurement of the strength of eight muscle groups and spirometry was performed. The interdependence of the variables was analyzed and the intergroup differences evaluated. Eighteen months later, it was found that one of the authors (B.J.), who was blind to the results of the first examination had instituted home mechanical ventilation on seven of the patients. The data were analyzed retrospectively for their predictive value as indicators of approaching ventilator dependency. RESULTS The seven patients who needed mechanical ventilation were the patients with DMD with the highest disability score (Egen Klassifikation [EK] sum > 20) and the smallest values for FVC < 1.2 L (FVC% < 30). We found a significant correlation (p = 0.002) between FVC% and the EK sum at the first examination and between the FVC% and the time until treatment with mechanical ventilation was instituted (p = 0.023). Although 7 of the 11 patients with SMA type II had FVC below 1.2 L and some of them had an EK sum score higher (indicating more disability) than some patients with DMD who needed mechanical ventilation, none of them required mechanical ventilation. CONCLUSION In this investigation, a combination of EK sum and FVC% provided a better indication of the approaching need for mechanical ventilation in the patients with DMD than the variables separately.
The Influence of Gender on New Technology Adoption and Use–Mobile Commerce

ABSTRACT This study empirically investigated the impact of gender differences on the adoption and use of a new technology-mobile commerce (m-Commerce) using 372 respondents enrolled in a business college in the Northeast United States. The adoption rate of m-Commerce for both male and female respondents was similar at about 30%. Respondents' perceptions of price, ease of use, and usefulness of m-Commerce services rather than gender were significant in distinguishing between adopters and nonadopters of m-Commerce services. Males and females adopted a similar staged pattern in their use of m-Commerce services with entertainment services demonstrating the highest adoption rate, followed by communication services, information services, and transaction services. Within service categories, male and female respondents used the same number of m-Commerce services in the entertainment category. Male respondents used more communication, information, and transaction services than females suggesting that males move through the adoption stages at a more rapid rate than females do. Implications for m-Commerce vendors and future research agendas are discussed.
Promising Novel Cytotoxic Agents and Combinations in Metastatic Prostate Cancer

Interest in investigating cytotoxic therapy has increased dramatically since a survival advantage was demonstrated in 2 phase III trials investigating docetaxel-based therapy in hormone-refractory prostate cancer. This result led to an expansion in research in this area with several ongoing trials evaluating docetaxel-based combinations and new cytotoxic agents.
Promoting empowerment? The World Bank's Village Investment Project in Kyrgyzstan

This article examines the extent to which the World Bank's community-driven Village Investment Project empowered people to influence the choice of local investments (micro-projects) and to exact accountability from their leaders. It is based on qualitative interviews and group discussions in 16 rural communities. The research demonstrates that the project provided an effective mechanism for responsive infrastructure delivery to address local priority needs. However, it did not improve accountability either within or outside the micro-project boundaries. The project's bottom-up development model was not by itself sufficient to enable people to exercise power over local government officials and informal leaders in the absence of effective horizontal accountability institutions within the state.
DNA Damage-induced Translocation of the Werner Helicase Is Regulated by Acetylation*

Werner syndrome is a rare autosomal recessive disorder involving the premature appearance of features reminiscent of human aging. Werner syndrome occurs by mutation of the WRN gene, encoding a DNA helicase. WRN contributes to the induction of the p53 tumor suppressor protein by various DNA damaging agents. Here we show that UV exposure leads to extensive translocation of WRN from the nucleolus to nucleoplasmic foci in a dose-dependent manner. Ionizing radiation also induces WRN translocation, albeit milder, partially through activation of the ATM kinase. The nucleoplasmic foci to which WRN is recruited display partial colocalization with PML nuclear bodies. The translocation of WRN into nucleoplasmic foci is significantly enhanced by the protein deacetylase inhibitor, Trichostatin A. Moreover, Trichostatin A delays the re-entry of WRN into the nucleolus at late times after irradiation. WRN is acetylatedin vivo, and this is markedly stimulated by the acetyltransferase p300. Importantly, p300 augments the translocation of WRN into nucleoplasmic foci. These findings support the notion that WRN plays a role in the cellular response to DNA damage and suggest that the activity of WRN is modulated by DNA damage-induced post-translational modifications of WRN and possibly WRN-interacting proteins.
A randomized phase I trial of a brief computer-delivered intervention for alcohol use during pregnancy.

BACKGROUND Drinking alcohol during pregnancy has a range of negative consequences for the developing fetus. Screening and brief intervention approaches have significant promise, but their population impact may be limited by a range of challenges to implementation. We, therefore, conducted preliminary acceptability and feasibility evaluation of a computer-delivered brief intervention for alcohol use during pregnancy. METHODS Participants were 50 pregnant women who screened positive for risky drinking during a routine prenatal clinic visit and were randomly assigned to computer-delivered brief intervention or assessment-only conditions. RESULTS Ratings of intervention ease of use, helpfulness, and other factors were high (4.7-5.0 on a 1-5 scale). Participants in both conditions significantly decreased alcohol use at follow-up, with no group differences; however, birth weights for infants born to women in the intervention group were significantly higher (p<0.05, d = 0.62). CONCLUSIONS Further development and study of computer-delivered screening and intervention for alcohol use during pregnancy are warranted.
Therapeutic management of premenstrual syndrome

Importance of the field: Premenstrual syndrome (PMS) is among the most common health problems reported by reproductive-age women. Estimates indicate that up to 25% of women may warrant treatment for the distress or impaired functioning associated with the symptoms. Areas covered in this review: The primary focus of this review is the clinical condition of PMS and randomized, placebo-controlled trials of PMS treatment. A literature search in PubMed was conducted for these topics. The most recent reports of specific treatments in controlled treatment studies and all meta-analyses were selected. What the reader will gain: Reports consistently indicate that serotonergic antidepressants reduce PMS symptoms compared to a placebo. Hormonal treatments are the most widely prescribed medical treatment. Some oral contraceptives and gonadotropin-releasing hormone analogs have demonstrated efficacy, particularly for women who want contraception and PMS symptom control. Numerous non-pharmacologic treatments are utilized, but efficacy is reported only for calcium supplements, Vitex agnus castus (chasteberry), and cognitive–behavioral therapies. Further research to develop new therapies for the 40% of women with PMS who do not respond to the currently available treatments is needed. Take home message: There are treatments with demonstrated efficacy for PMS, and the majority of women can be helped.
Abnormal properties of skin fibroblasts from patients with breast cancer

The growth properties of fibroblasts from the thoracic skin of patients with mammary cancers were compared to those of fibroblastic cultures from patients with benign lesions or having undergone surgery for non‐neoplastic diseases. As expected, an inverse correlation was found between the doubling potential of fibroblasts in vitro and the donor's age for cells from patients with benign lesions; however no correlation, was found with cultures from cancer patients. Moreover, the latter group responded in an abnormal way to three biological parameters: anchorage dependence, colony formation on monolayers of normal human epithelial cells and saturation densities in overcrowded culture conditions. Skin fibroblasts from one patient with a benign lesion, whose mother had developed a breast cancer, displayed all the abnormal growth properties. Periodic controls of this patient resulted in the early detection of a carcinoma 3 years after the first operation for a benign microcystic lesion. Finally, we found that multiple subcultivations in overcrowded culture conditions cause the selection of a fibroblastic cell subset with greater growth potential which, in the cell strain tested, could invade foreigh tissus in vitro.
Differentially Fed Ring-Shaped Planar Printed Antenna with Higher Order Mode Suppression

In this paper, a planar printed antenna configured by a ring-shaped structure incorporated with a letter of S structure is presented. The antenna is designed to work at Long Term Evolution (LTE) frequency band of 900 MHz for radio frequency (RF) energy harvesting application. A ring-shaped planar printed antenna is applied as a main part of configuration to resonate at the frequency of 900 MHz. Meanwhile another structure of S letter or S-shaped is incorporated into inside of the ring to suppress the higher order mode of resonant frequency naturally generated by the ring-shaped structure. The proposed antenna is then deployed on an FR4 epoxy dielectric substrate with the thickness of 1.6 mm. From the characterization result, it shows that the proposed antenna has a good suppression for higher order mode with the −10 dB impedance bandwidth of around 250 MHz and the resonant frequency of 900 MHz satisfying the bandwidth requirement of desired application.
Single-stranded DNA binding protein-assisted fluorescence polarization aptamer assay for detection of small molecules.

Here, we describe a new fluorescence polarization aptamer assay (FPAA) strategy which is based on the use of the single-stranded DNA binding (SSB) protein from Escherichia coli as a strong FP signal enhancer tool. This approach relied on the unique ability of the SSB protein to bind the nucleic acid aptamer in its free state but not in its target-bound folded one. Such a feature was exploited by using the antiadenosine (Ade)-DNA aptamer (Apt-A) as a model functional nucleic acid. Two fluorophores (fluorescein and Texas Red) were introduced into different sites of Apt-A to design a dozen fluorescent tracers. In the absence of the Ade target, the binding of the labeled aptamers to SSB governed a very high fluorescence anisotropy increase (in the 0.130-0.200 range) as the consequence of (i) the large global diffusion difference between the free and SSB-bound tracers and (ii) the restricted movement of the dye in the SSB-bound state. When the analyte was introduced into the reaction system, the formation of the folded tertiary structure of the Ade-Apt-A complex triggered the release of the labeled nucleic acids from the protein, leading to a strong decrease in the fluorescence anisotropy. The key factors involved in the fluorescence anisotropy change were considered through the development of a competitive displacement model, and the optimal tracer candidate was selected for the Ade assay under buffer and realistic (diluted human serum) conditions. The SSB-assisted principle was found to operate also with another aptamer system, i.e., the antiargininamide DNA aptamer, and a different biosensing configuration, i.e., the sandwich-like design, suggesting the broad usefulness of the present approach. This sensing platform allowed generation of a fluorescence anisotropy signal for aptamer probes which did not operate under the direct format and greatly improved the assay response relative to that of the most previously reported small target FPAA.
DEVELOPING PROJECT COMPETENCE: EMPIRICAL REGULARITIES IN COMPETITIVE PROJECT OPERATIONS

Projects play key roles in many modern industries and firms. The management of these economic systems, project management, is continuously developed and considered to be at the core of competitive advantage. Traditional research on project management has, however, paid scant attention to the capabilities needed for firms that depend on projects in their business operations. Furthermore, traditional work on the capabilities and competence of the firm pays limited attention to the specific traits of project processes. In the present paper, project competence is considered to be one of three strategic competencies frequently observed in modern firms. We develop an overall model for the analysis of project competence. The proposed model identifies four building blocks of project competence, namely project generation, project organising, project leadership and teamwork. In an empirical study we elaborate on some empirical regularities in the operations of firms that to a large extent depend on projects. The companies studied are ABB, Ericsson, Skanska and Posten. We illustrate the possibilities of this model and show some variations between the companies. The article illustrates how the project competence framework might explain the differences among the competitiveness of firms.
Enhancing embedded SRAM security and error tolerance with hardware CRC and obfuscation

This paper proposes a scalable solution for obstructing and detecting malicious activity as well as erroneous events during mission mode operation of untrusted memories. The approach obfuscates data written into a memory and remaps the location of memory contents in a manner difficult for an attacker to predict, making it harder for a Hardware Trojan to be deterministically triggered or controlled by malicious agents. Simultaneously, the approach aids in the detection of soft errors. To our knowledge, this approach is among the first to reconcile SRAM security with SRAM soft error reliability. Simulation data gathered from a production-worthy silicon development environment confirms the viability of our method.
Diabetic nephropathy: where are we on the journey from pathophysiology to treatment?

Diabetic nephropathy affects 30–40% of people with diabetes, and is the leading cause of end‐stage kidney disease. The current treatment paradigm relies on early detection, glycaemic control and tight blood pressure management with preferential use of renin‐angiotensin system blockade. This strategy has transformed outcomes in diabetic kidney disease over the last 20 years. Over the last two decades we have also witnessed significant advances in the understanding of the pathophysiology of diabetic nephropathy; however, despite this new knowledge, we have yet to develop new treatments of proven efficacy. Whilst a continued emphasis on preclinical and clinical research is clearly needed, clinicians treating people with diabetes should not forget that, in the short term, the greatest gains are likely to be realised by more consistent deployment of existing therapies.
MARKET EFFICIENCY AND THE COST OF CAPITAL: THE STRANGE CASE OF FIRE AND CASUALTY INSURANCE COMPANIES

FIRE AND CASUALTY insurers are financial intermediaries which use funds advanced to them by customers, along with their own funds, to invest in securities. The majority of other intermediaries pay interest or provide a share in profits for the use of the funds advanced to them. Fire, casualty and marine insurance companies do not make an explicit payment for the use of customers' funds, but pay instead by relieving the customer of risks which the company assumes. To the extent that insurers earn positive underwriting profits, they in fact charge the customer for using his funds and assuming his risks.1 The cost of funds raised in this way is of substantial practical concern. Insurance rates are at least nominally regulated in all states of the U.S. and in some Canadian provinces. Where rates are regulated, the question of what allowance, if any, should be incorporated for underwriting profits in setting rates, is an important one, the answer to which is dependent on an evaluation of the cost of capital to the insurers. Where rates are not formally regulated, but determined by a mixture of market forces and partial cartels (rating bureaus), an evaluation of whether the resultant underwriting margins are consistent with competitive behavior or reflect monopolistic control over rates can be a useful ingredient in assessing the industry's performance. In this paper we develop a model which considers the combined asset-liability portfolio of a typical insurance company. The model enables us to compare the risk-expected return options open to such a company with those available to other capital market participants. In addition, we consider the process of price formation in competitive insurance markets, which in turn determines the magnitude of underwriting margins and, indirectly, the cost of capital to insurance companies.2 The model is developed in Section II. In Section III we examine the realized rates of return on policyholders' surplus and risk levels of 25
HOTAIR, a cell cycle-associated long noncoding RNA and a strong predictor of survival, is preferentially expressed in classical and mesenchymal glioma.

BACKGROUND Long noncoding RNA Hox transcript antisense intergenic RNA (HOTAIR) has been characterized as a negative prognostic factor in breast and colon cancer patients. The clinical significance and function of HOTAIR in glioma remains unclear. METHODS We analyzed the clinical significance of HOTAIR in 3 different glioma cohorts with gene expression data, including correlation with tumor grade, prognosis, and molecular subtype. The function of HOTAIR in glioma was explored by performing gene set enrichment analysis and in vitro and in vivo experiments. RESULTS HOTAIR expression was closely associated with glioma grade and poor prognosis. Multivariate Cox regression analysis revealed that HOTAIR was an independent prognostic factor in glioblastoma multiforme patients. HOTAIR expression correlated with glioma molecular subtype, including those of The Cancer Genome Atlas. HOTAIR was preferentially expressed in the classical and mesenchymal subtypes compared with the neural and proneural subtypes. A gene set enrichment analysis designed to show gene set differences between patients with high and low HOTAIR expression indicated that HOTAIR expression was associated with gene sets involved in cell cycle progression. HOTAIR reduction induced colony formation suppression, cell cycle G0/G1 arrest, and orthotopic tumor growth inhibition. CONCLUSION Our data establish that HOTAIR is an important long noncoding RNA that primarily serves as a prognostic factor for glioma patient survival, as well as a biomarker for identifying glioma molecular subtypes, a critical regulator of cell cycle progression.
Recent Activities of Japanese Microwave Industry

In APMC2014, many excellent papers were submitted from Japanese microwave industries. Among them, 7 papers are invited from Japanese major microwave related companies, namely Mitsubishi Electric Corp., NTT Docomo, Murata Manufacturing Co., Hitachi Ltd, Toshiba Corp., Fujitsu limited and NEC Corp. They are all cutting-edge researches or most recent deployments of microwave technologies in Japan. In this paper, points of the 7 papers are introduced.