Miracle-dz/UniFAR-FTUs huggingface dataset:
TEMPORARY MONOSACCHARIDE INTOLERANCE

An infant presented at three months with intolerance of glucose, galactose and fructose. It was thought that this was possibly secondary to staphylococcal infection. Recovery of monosaccharide intolerance coincided with recovery from infection. The infant was treated with a sugar‐free diet which is described in detail. It is important to detect and correct ketosis and/or hypoglycaemia at an early stage when such a diet is used.
What to eat now? Shifts in polar bear diet during the ice-free season in western Hudson Bay

Under current climate trends, spring ice breakup in Hudson Bay is advancing rapidly, leaving polar bears (Ursus maritimus) less time to hunt seals during the spring when they accumulate the majority of their annual fat reserves. For this reason, foods that polar bears consume during the ice-free season may become increasingly important in alleviating nutritional stress from lost seal hunting opportunities. Defining how the terrestrial diet might have changed since the onset of rapid climate change is an important step in understanding how polar bears may be reacting to climate change. We characterized the current terrestrial diet of polar bears in western Hudson Bay by evaluating the contents of passively sampled scat and comparing it to a similar study conducted 40 years ago. While the two terrestrial diets broadly overlap, polar bears currently appear to be exploiting increasingly abundant resources such as caribou (Rangifer tarandus) and snow geese (Chen caerulescens caerulescens) and newly available resources such as eggs. This opportunistic shift is similar to the diet mixing strategy common among other Arctic predators and bear species. We discuss whether the observed diet shift is solely a response to a nutritional stress or is an expression of plastic foraging behavior.
Design of a New Sensor for Determination of the Effects of Tractor Field Usage in Southern Spain: Soil Sinkage and Alterations in the Cone Index and Dry Bulk Density

Variations in sinkage and cone index are of crucial importance when planning fieldwork, and for determining the trafficability of farm machinery. Many studies have highlighted the link between higher values of these parameters and dramatic decreases in crop yield. Variations in the dry bulk density and cone index of clayey soil in Southern Spain were measured following each of five successive passes over the same land with the three types of tractor most widely used in the area (tracked, two-wheel drive and four-wheel drive). In addition, sinkage (rut depth) of the running gear was measured using a laser microrelief profile meter. This device, which integrates three sensors, was specifically designed for these experiments, as was an electrical penetrometer to determine the cone index, and both instruments proved reliable and accurate in the field. The main goal of this study was to design, manufacture and test these new devices. The first pass caused most soil alteration when compared to successive passes for all types of tractor tested and soil conditions prevailing during the tests. (Heavier) four-wheel drive tractors were found to cause greater soil damage (sinkage, cone index and dry bulk density) than two-wheel drive and track tractors. There was no statistically significant difference between the two latter types. The greatest alterations were recorded in the top 10 cm of the soil. The results show that soil compaction should be avoided as much as possible. This can be achieved by ensuring that tractors always travel along the same tracks, especially in the wet season. At present these aspects are not considered by farmers in this area.
Metabolism of a Heterocyclic Amine Colon Carcinogen in Young and Old Rats

The incidence of colon cancer increases with age, and this may be related to altered metabolism and disposition of carcinogens. One such carcinogen implicated in colon cancer is the heterocyclic amine found in well done meat, 2-amino-3-methylimidazo[4,5-f]quinoline (IQ). The purpose of these studies was to determine whether the disposition and metabolism of IQ changes with age, comparing young (3-month) and old (22- to 24-month) male F344 rats. Animals were treated with vehicle or β-naphthoflavone (BNF), an inducer of drug-metabolizing cytochromes P450. Disposition and metabolism of IQ were determined after i.p. injection of radiolabeled IQ. Urinary IQ metabolites were identified and quantitated by high-performance liquid chromatography and mass spectroscopy. In BNF-treated animals, total radiolabeled IQ excretion by old rats was less than half that of young rats. Binding of radiolabeled IQ metabolites by the old kidney was 10 times higher than that of the young. There were no age differences in intestinal and hepatic binding. There was a significant age-related increase in IQ conjugation to glucuronic acid and a decrease in conjugation to sulfate regardless of treatment. The induction of renal CYP1A1, a major P450 involved in IQ metabolism, by BNF did not change with age. Changes in IQ metabolism with age along with altered renal function may contribute to the decreased urinary excretion and increased renal binding of IQ and/or its metabolites seen in the old animals.
Transcriptional Profiling of Equine Conceptuses Reveals New Aspects of Embryo-Maternal Communication in the Horse1

Establishment and maintenance of pregnancy are critically dependent on embryo-maternal communication during the preimplantation period. The horse is one of the few domestic species in which the conceptus-derived pregnancy recognition signal has not been identified. To gain new insights into the factors released by the equine conceptus, transcriptional profiling analyses of conceptuses retrieved 8, 10, 12, and 14 days after ovulation were performed using a whole-genome microarray. Selected array data were confirmed using quantitative PCR, and the expression of proteins of interest was confirmed using immunohistochemistry and Western blotting. Gene ontology classification of differentially regulated transcripts underlines the ongoing embryo-maternal dialogue. Transcript showing higher expression levels as conceptus' development proceeds mainly localizes to the extracellular environment, thereby having the potential to act upon the uterine environment. Genes involved in the positive regulation of the immune system are enriched among transcripts displaying decreased expression, reflecting the need of the semiallograft conceptus to be protected from the immune system. A subset of differentially expressed genes, such as BRCA1 and FGF2, has previously been described to be expressed by early stages of embryonic development, whereas other transcripts are apparently unique to equine conceptuses, as their expression has not been reported in other species. These transcripts include fibrinogen subunits, the expressions of which were confirmed at the mRNA and protein level. Furthermore, results indicate the counteraction of trophoblast invasion, and that the conceptus appears to regulate changes in sialic acid content of its capsule, an event suggested to be essential for successful establishment of pregnancy.
Evaluation of skeletal status by quantitative ultrasonometry in postmenopausal women without known risk factors for osteoporosis

The objective of our study was to evaluate bone density in Italian postmenopausal women without clinical risk factors for osteoporosis resident in the Naples area using quantitative ultrasonometry of bone (QUS). Subjects were 1149 Italian postmenopausal women (age: 54.9 ± 5.0 years (mean ± standard deviation); range: 45–74 years) resident in the Naples area. Clinical risk factors for osteoporosis resulting in exclusion from the study were family history of osteoporosis, dietary, smoking and alcohol habits, personal history of fractures and/or metabolic diseases. The following QUS parameters were calculated: amplitude-dependent speed of sound (AD-SoS), T-score and Z-score. We found significant inverse correlations between AD-SoS and age (r = – 0.23), time since menopause (r = – 0.25) and body mass index (BMI) (r = – 0.16). The same was observed for T-score. In contrast, Z-score showed a significant positive correlation with age and time since menopause, and a negative correlation with BMI. A T-score suggestive of high risk for osteoporosis (less than −3.2) was found in 1.6% of subjects, while a T-score suggestive of moderate risk for osteoporosis (between −3.2 and −2) was found in 19.3% of patients. In this group of women without clinical risk factors for osteoporosis we found a very low prevalence of QUS results suggesting a high risk for osteoporosis. However, a condition of ‘moderate’ risk for osteoporosis was present in a remarkable percentage of these women.
High voltage semiconductor component has low leakage current.

La presente invention concerne un composant semiconducteur haute tension comprenant une region centrale (N- ) faiblement dopee encadree de couches (P1 , P3 ) a plus fort niveau de dopage formant avec la region centrale des premiere et seconde jonctions (J1 , J2 ) susceptibles de supporter ladite haute tension, dans lequel les premiere et seconde jonctions affleurent sur une meme surface principale du composant, de part et d'autre d'une surface apparente de ladite region centrale, et dans lequel un sillon est forme dans toute ladite surface apparente et est rempli d'un verre de passivation (18). La surface du verre est recouverte, au-dessus du contour de chaque jonction, d'une metallisation (21, 22) en contact avec la couche correspondant a cette jonction.
Comparisons of tests of distributional assumption in Poisson regression model

ABSTRACT Count data consists of discrete non-negative integer values. Poisson regression model is one of the most popular model used to model count data. This model assumes that response variable has Poisson distribution. The purpose of this article is to assess distributional assumption of this model by using some goodness of fit tests. These tests are compared in respect to type I error and power rates of tests with different samples, parameters and sample sizes. Simulation study suggests that the most powerful tests are generally Dean–Lawless and Cameron–Trivedi score tests.
Implementation and Operational Research: Community-Based Adherence Clubs for the Management of Stable Antiretroviral Therapy Patients in Cape Town, South Africa A Cohort Study

Background:Community-based models of antiretroviral therapy (ART) delivery are widely discussed as a priority in the expansion of HIV treatment services, but data on their effectiveness are limited. We examined outcomes of ART patients decentralized to community-based adherence clubs (CACs) in Cape Town, South Africa and compared these to patients managed in the community health center. Methods:The analysis included 8150 adults initiating ART from 2002 to 2012 in a public sector service followed until the end of 2013. From June 2012, stable patients (on ART >12 months, suppressed viral load) were referred to CACs. Loss to follow-up (LTFU) was compared between services using proportional hazards models with time-varying covariates and inverse probability weights of CAC participation. Findings:Of the 2113 CAC patients (71% female, 7% youth ages ⩽24 years), 94% were retained on ART after 12 months. Among CAC patients, LTFU [adjusted hazard ratio (aHR): 2.17, 95% confidence interval (CI): 1.26 to 3.73] and viral rebound (aHR 2.24, 95% CI: 1.00 to 5.04) were twice as likely in youth (16–24 years old) compared with older patients, but no difference in the risk of LTFU or viral rebound was observed by sex (P-values 0.613 and 0.278, respectively). CAC participation was associated with a 67% reduction in the risk of LTFU (aHR: 0.33, 95% CI: 0.27 to 0.40) compared with community health centre, and this association persisted when stratified by patient demographic and clinic characteristics. Interpretation:CACs are associated with reduced risk of LTFU compared with facility-based care. Community-based models represent an important development to facilitate ART delivery and possibly improve patient outcomes.
A machine vision extension to the Ruby programming language using OpenCV and FFI

This paper introduces the OpenCV-FFI software package, which exposes datatypes and functions from the OpenCV computer vision library into the Ruby programming language. OpenCV-FFI uses the foreign function interface (FFI) to produce a Ruby API which mirrors the OpenCV C API; further layers of complexity are then built on that core API. Example code and benchmarking results show the effectiveness of using OpenCV-FFI for scripting OpenCV code within Ruby, as well as demonstrating the pitfalls of incautious use of Ruby iteration. Finally, there is a discussion of the relative advantages and disadvantages of the FFI-based approach versus a bespoke extension library written in Ruby-C or the use of an automatic wrapper generation packages (e.g., SWIG).
Validation of the Household Food Insecurity Access Scale in rural Tanzania

Abstract Objective The purpose of the present study was to test the construct validity, internal consistency and convergent validity of the Household Food Insecurity Access Scale (HFIAS) in measuring household food insecurity in rural Tanzania, and to determine socio-economic characteristics associated with household food insecurity. Design Key informant interviews and a cross-sectional survey were conducted in February and March 2008. Setting Rural Iringa, Tanzania. Subjects Key informant interviews were conducted with twenty-one purposively selected male and female village leaders. For the household surveys, a sample of 237 households with mothers (caregivers) and at least one child between 1 and 5 years of age were included. Results Approximately 20·7 % of the households were categorized as food-secure, 8·4 % as mildly food-insecure, 22·8 % as moderately food-secure and 48·1 % as severely food-insecure. Two main factors emerged from the rotated principal component factor analysis: (i) insufficient food quality; and (ii) insufficient food intake. Both factors explained 69 % of the total variance. The full food insecurity scale and the two subscales had good internal consistency (Cronbach’s α = 0·83–0·90). Food security, as measured by HFIAS, was positively associated with maternal education, husband’s education, household wealth status, being of an agricultural rather than pastoral tribe and animal-source food consumption; it was negatively associated with maternal age and household size. Conclusions The HFIAS measurement instrument shows validity and reliability in measuring household food insecurity among poor households in rural Tanzania.
Collaborative Brushing and Linking for Co‐located Visual Analytics of Document Collections

Many real‐world analysis tasks can benefit from the combined efforts of a group of people. Past research has shown that to design visualizations for collaborative visual analytics tasks, we need to support both individual as well as joint analysis activities. We present Cambiera, a tabletop visual analytics tool that supports individual and collaborative information foraging activities in large text document collections. We define collaborative brushing and linking as an awareness mechanism that enables analysts to follow their own hypotheses during collaborative sessions while still remaining aware of the group's activities. With Cambiera, users are able to collaboratively search through documents, maintaining awareness of each others' work and building on each others' findings.
Are common childhood or adolescent infections risk factors for schizophrenia and other psychotic disorders?

Postnatal infection may represent a preventable risk factor for onset of psychotic disorders in adolescence and early adulthood. The mechanism of action is likely to involve site‐directed triggering of the brain's innate immune system, mediated principally through localised activation of microglial cells. This triggering may occur in response to systemic inflammatory stimuli, without direct involvement of the central nervous system. Microglial activation can represent a primary response or a secondary phenomenon at sites made vulnerable by prior injury; that is, areas containing previously activated microglia will respond more strongly to a new stimulus. The presence of activated microglia is indicative of a recent insult or active disease. It is not characteristic of long‐established neurodevelopmental abnormalities. Activated microglia, acting through a variety of cytokine and other signal systems, have the capacity to significantly interfere with synaptic turnover and thus, over time, alter synaptic architecture and function. This pathophysiological path should be investigated more systematically as it may explain a novel “neuroprotective” mode of action for some existing antipsychotic compounds.
The co-operative model as a means of stakeholder management: An exploratory qualitative analysis

The South African economy has for some time been characterised by high unemployment, income inequality and a skills mismatch, all of which have contributed to conflict between business, government and labour. The co-operative model of stakeholder management is examined as a possible mitigating organisational form in this high-conflict environment. International experience indicates some success with co-operative models but they are not easy to implement effectively and face severe obstacles. Trust and knowledge sharing are critical for enabling a co-operative model of stakeholder management, which requires strong governance and adherence to strict rules. The model must balance the tension between optimisation of governance structures and responsiveness to members' needs. Furthermore, support from social and political institutions is necessary. We find barriers to scalability which manifest in the lack of depth of business skills, negative perception of the co-operative model by external stakeholders, government ambivalence, and a lack of willingness on the part of workers to co-operate for mutual benefit.
Environment maps and the perception of shape from mirror reflections

Environment maps are commonly used in computer graphics to approximate the appearance of smoothly curved surfaces with mirror-like reflectance. Perceiving the shape of such surfaces is a challenging task for the visual system, however, because the image intensities are determined both by the surface shape and by the environment [Fleming et al. 2004]. Here we extend our recent study of the perception of qualitative shape of mirror surfaces [Faisman and Langer 2013] by examining more closely how qualitative shape perception varies with the environment maps that are used.
An NF-κB and Slug Regulatory Loop Active in Early Vertebrate Mesoderm

Background In both Drosophila and the mouse, the zinc finger transcription factor Snail is required for mesoderm formation; its vertebrate paralog Slug (Snai2) appears to be required for neural crest formation in the chick and the clawed frog Xenopus laevis. Both Slug and Snail act to induce epithelial to mesenchymal transition (EMT) and to suppress apoptosis. Methodology & Principle Findings Morpholino-based loss of function studies indicate that Slug is required for the normal expression of both mesodermal and neural crest markers in X. laevis. Both phenotypes are rescued by injection of RNA encoding the anti-apoptotic protein Bcl-xL; Bcl-xL's effects are dependent upon IκB kinase-mediated activation of the bipartite transcription factor NF-κB. NF-κB, in turn, directly up-regulates levels of Slug and Snail RNAs. Slug indirectly up-regulates levels of RNAs encoding the NF-κB subunit proteins RelA, Rel2, and Rel3, and directly down-regulates levels of the pro-apopotic Caspase-9 RNA. Conclusions/Significance These studies reveal a Slug/Snail–NF-κB regulatory circuit, analogous to that present in the early Drosophila embryo, active during mesodermal formation in Xenopus. This is a regulatory interaction of significance both in development and in the course of inflammatory and metastatic disease.
Potential mechanisms of thyroid disruption in humans: interaction of organochlorine compounds with thyroid receptor, transthyretin, and thyroid-binding globulin.

Organochlorine compounds, particularly polychlorinated biphenyls (PCBs), alter serum thyroid hormone levels in humans. Hydroxylated organochlorines have relatively high affinities for the serum transport protein transthyretin, but the ability of these compounds to interact with the human thyroid receptor is unknown. Using a baculovirus expression system in insect cells (Sf9 cells), we produced recombinant human thyroid receptor ss (hTRss). In competitive binding experiments, the recombinant receptor had the expected relative affinity for thyroid hormones and their analogs. In competitive inhibition experiments with PCBs, hydroxylated PCBs (OH-PCBs), DDT and its metabolites, and several organochlorine herbicides, only the OH-PCBs competed for binding. The affinity of hTRss for OH-PCBs was 10,000-fold lower (Ki = 20-50 microM) than its affinity for thyroid hormone (3,3',5-triiodothyronine, T3; Ki = 10 nM). Because their relative affinity for the receptor was low, we tested the ability of OH-PCBs to interact with the serum transport proteins--transthyretin and thyroid-binding globulin (TBG). With the exception of one compound, the OH-PCBs had the same affinity (Ki = 10-80 nM) for transthyretin as thyroid hormone (thyroxine; T4). Only two of the OH-PCBs bound TBG (Ki = 3-7 microM), but with a 100-fold lower affinity than T4. Hydroxylated PCBs have relatively low affinities for the human thyroid receptor in vitro, but they have a thyroid hormonelike affinity for the serum transport protein transthyretin. Based on these results, OH-PCBs in vivo are more likely to compete for binding to serum transport proteins than for binding to the thyroid receptor. ImagesFigure 1Figure 2Figure 3Figure 4Figure 5Figure 6Figure 7
Adaptive Hausdorff Estimation of Density Level Sets

Consider the problem of estimating the γ-level set G∗γ = {x : f(x) ≥ γ} of an unknown d-dimensional density function f based on n independent observations X1, . ,Xn from the density. This problem has been addressed under global error criteria related to the symmetric set difference. However, in certain applications such as anomaly detection and clustering, a spatially uniform confidence interval is desired to ensure that the estimated set is close to the target set everywhere. The Hausdorff error criterion provides this degree of uniformity and hence is more appropriate in such situations. The minimax optimal rate of Hausdorff error convergence is known to be (n/ log n) for level sets with boundaries that have a Lipschitz functional form, and where the parameter α characterizes the regularity of the density around the level of interest. However, previously developed estimators are non-adaptive to the density regularity and assume knowledge of α. Moreover, the estimators proposed in previous work achieve the minimax optimal rate for rather restricted classes of sets (for example, the boundary fragment and star-shaped sets) that effectively reduce the set estimation problem to a function estimation problem. This characterization precludes level sets with multiple connected components, which are fundamental to many applications. This paper presents a fully data-driven procedure that is adaptive to unknown local density regularity, and achieves minimax optimal Hausdorff error control for a class of level sets with very general shapes and multiple connected components.
Analysis of a mixed inter programming model for microarray data classification

Gene expression profiling has been successfully use to identity potential cancer diagnosis and therapeutic target in the past few years. Since there are often large number of potential genes, an important issue is to find a small subset of genes that are differentially expressed between different clinical outcomes (or) related subset to cancer patients survival time, and thus can be used to build prognosis and predictors.