Miracle-dz/UniFAR-FTUs huggingface dataset:
Bone Marrow Mesenchymal Stem-Cell-Derived Exosomes Ameliorate Deoxynivalenol-Induced Mice Liver Damage

Deoxynivalenol (DON) is a kind of Fusarium toxin that can cause a variety of toxic effects. DON is mainly metabolized and detoxified by the liver. When the concentration of DON exceeds the metabolic capacity of the liver, it will trigger acute or chronic damage to the liver tissue. Previous studies demonstrated that bone marrow mesenchymal stem-cell-secreted exosomes (BMSC-exos) reduce liver injury. Therefore, we issue a hypothesis that in vitro-cultured rat BMSC-secreted exos could ameliorate liver damage after 2 mg/kg bw/day of DON exposure. In total, 144 lipids were identified in BMEC-exos, including high polyunsaturated fatty acid (PUFA) levels. BMSC-exos treatment alleviated liver pathological changes and decreased levels of alanine aminotransferase, aspartate aminotransferase, inflammatory factors interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and lipid peroxidation. Otherwise, low or high BMSC-exos treatment obviously changes DON-induced hepatic oxylipin patterns. According to the results from our correlation network analysis, Pearson correlation coefficient analysis, and hierarchical clustering analysis, the top 10% oxidized lipids can be classified into two categories: one that was positively correlated with copper–zinc superoxide dismutase (Cu/Zn SOD) and another that was positively correlated with liver injury indicators. Altogether, BMSC-exos administration maintained normal liver function and reduced oxidative damage in liver tissue. Moreover, it could also significantly change the oxylipin profiles under DON conditions.
Teaching performance at private universities in Medan City: Analysis of factors affecting university governance

The purpose of this research is to find out what factors influence the performance of tertiary institutions in obtaining accreditation. A structural Equation Model (SEM) is used for data analysis. The data processing tool in the buying and selling model in this study uses Partial Least Squares (PLS). The research design is causal research and the variables used are the performance of private universities governance, funding, internal audit, participation in budgeting and risk management. The results of the study show that internal audit has an impact on university governance. Budget participation and risk management have a positive effect on good university governance while financing and internal audit have a negative effect on university performance. Empirical evidence analyzes the effect of risk management on university performance at private universities in Medan City.
The effect of age and mitigation strategies during hot water immersion on orthostatic intolerance and thermal stress

What is the central question of this study? The aim was to characterize adverse responses to whole‐body hot water immersion and to investigate practical strategies to mitigate these effects. What is the main finding and its importance? Whole‐body hot water immersion induced transient orthostatic hypotension and impaired postural control, which recovered to baseline within 10 min. Hot water immersion was well tolerated by middle‐aged adults, but younger adults suffered from a greater frequency and severity of dizziness. Cooling the face with a fan or not immersing the arms can mitigate some of these adverse responses in younger adults.
Comparing the Perceptions of Reciprocal- and Near-Peer Objective Structured Clinical Examinations (OSCEs) in Medical Students

Introduction: The Objective Structured Clinical Examination (OSCE) is utilized by medical schools to assess students’ competency in clinical skills. Literature has shown that first-year students who were tutored by fourth-year students (MS4s; near-peer) in practice OSCEs reported self-perceived improvement in OSCE skills. There is a lack of research regarding the effectiveness of first-year (MS1) pairs for reciprocal-peer practice OSCEs. This study aims to assess if virtual reciprocal-peer OSCEs provide comparable learning opportunities to virtual near-peer OSCEs. Methods: MS1 students were assigned to work with a near-peer or a reciprocal-peer for one week, and then switched protocols the second week. One student in each reciprocal-peer pair was assigned to act as a standardized patient (SP). Their partner took a history, interpreted physical exam findings, prepared a note, and gave an oral presentation. The pair then switched roles using a second case. The near-peer group followed the same procedure, without the reversal of roles. Results: A total of 135 MS1s participated in the first week and 129 in the second week. Students agreed that working with a near-peer was more valuable than a reciprocal-peer in the following parameters: peer feedback (N=113, 89%), history-taking skills (N=101, 80%), physical exam skills (N=102, 81%), and note-writing skills (N=109, 89%). Pairwise comparison utilizing Wilcoxon signed-rank test indicated participants preferred the choice of a fourth-year student partner over an MS1 partner (Z=1.436, p<0.001). Conclusion: Participants found working with a near-peer increased confidence in their clinical skills and near-peer feedback was more valuable. Although MS1s found that watching and evaluating their peers in a reciprocal-peer exercise was beneficial, students overwhelmingly preferred working with MS4s due to more valuable feedback.
Acute and Chronic Changes in Myocardial Work Parameters in Patients with Severe Primary Mitral Regurgitation Undergoing Transcatheter Edge-to-Edge Repair

Background: The noninvasive assessment of myocardial work (MW) allows for the evaluation of left ventricular (LV) performance by considering the effect of LV afterload. This study aims to evaluate the acute and chronic impact of transcatheter edge-to-edge repair (TEER) on MW parameters and LV remodeling in patients with severe primary mitral regurgitation (PMR). Methods: A total of 71 patients (age: 77 ± 9 years, females: 44%) with moderate–to-severe or severe PMR (effective regurgitant orifice: 0.57 ± 0.31 cm2; regurgitant volume: 80 ± 34 mL; LV end-systolic diameter: 42 ± 12 mm) underwent TEER after a global assessment by the heart team. MW indices were evaluated before the procedure, at hospital discharge, and at 1-year follow-up. LV remodeling was described as the percentage variation in LVEDV between baseline and 1-year follow-up. Results: TEER caused an acute reduction in LVEF, global longitudinal strain (GLS), global MW index (GWI), work efficiency (GWE), and mechanical dispersion (MD) and a significant increase in wasted work (GWW). One year after the procedure, GLS, GWI, GWE, and MD recovered, whereas GWW remained significantly impaired. Baseline GWW (β = −0.29, p = 0.03) was an independent predictor of LV reverse remodeling at 1-year follow-up. Conclusions: In patients with severe PMR undergoing TEER, the acute reduction in LV preload causes significant impairment to all the parameters of LV performance. Baseline GWW was the only independent predictor of LV reverse remodeling, suggesting that a lower myocardial energetic efficiency in the context of chronic preload increase might impact the left ventricular response to mitral regurgitation correction.
Assessment of Analytical Load and Dynamic Increase Factors for Progressive Collapse Analysis of Building Frames

Linear and nonlinear static procedures for evaluating the alternative load paths of building frames under column loss conditions have been refined in the latest Unified Facilities Criteria UFC 4-023-03 in 2009. One substantial modification in the 2009 version is the consideration of material nonlinearity for the load increase factor (LIF) and dynamic increase factor (DIF) in static analyses. In this study, analytical LIF and DIF expressions are compared with the empirical formulae recommended in the UFC guidelines. Static and dynamic analyses are carried out for eight moment-resisting frames subjected to column loss. The resulting LIFs and DIFs are used to evaluate the adequacy of the analytical expressions as compared to the empirical formulae. Accuracy of the analytical formulae in predicting the collapse resistance is also demonstrated. The study results indicate that the proposed analytical expressions may be an alternative in estimating the LIF and DIF for progressive collapse analysis.
Knowledge, Attitudes and Practice Regarding Antibiotic Prescription by Medical Interns: A Qualitative Study in Spain

Antibiotic resistance is an issue of growing importance in the public health sphere. Medical interns are of great relevance when it comes to the source of this problem. This study therefore sought to ascertain which factors influence the management of antibiotic therapy by this population, in order to pinpoint the possible causes of misprescribing habits. We conducted a qualitative study based on focus group techniques, with groups consisting of medical interns from the Santiago de Compostela Clinical University Teaching Hospital. Our study identified factors which the participants considered to be determinants of antibiotic use and their relationship with the appearance of resistance. The single most repeated factor was the influence of the attending physician’s judgement; other factors included a high healthcare burden or prescribing inertia. This stage is an opportunity to correct misprescribing habits, by implementing educational interventions aimed at modifying the identified factors.
Website quality evaluation: a model for developing comprehensive assessment instruments based on key quality factors

PurposeThe field of website quality evaluation attracts the interest of a range of disciplines, each bringing its own particular perspective to bear. This study aims to identify the main characteristics – methods, techniques and tools – of the instruments of evaluation described in this literature, with a specific concern for the factors analysed, and based on these, a multipurpose model is proposed for the development of new comprehensive instruments.Design/methodology/approachFollowing a systematic bibliographic review, 305 publications on website quality are examined, the field's leading authors, their disciplines of origin and the sectors to which the websites being assessed belong are identified, and the methods they employ characterised.FindingsEvaluations of website quality tend to be conducted with one of three primary focuses: strategic, functional or experiential. The technique of expert analysis predominates over user studies and most of the instruments examined classify the characteristics to be evaluated – for example, usability and content – into factors that operate at different levels, albeit that there is little agreement on the names used in referring to them.Originality/valueBased on the factors detected in the 50 most cited works, a model is developed that classifies these factors into 13 dimensions and more than 120 general parameters. The resulting model provides a comprehensive evaluation framework and constitutes an initial step towards a shared conceptualization of the discipline of website quality.
Trait-Level Resilience in Pet Dogs—Development of the Lincoln Canine Adaptability Resilience Scale (L-CARS)

Simple Summary Dogs are exposed to many stressors and appear to vary in their ability to cope with these, but the concept of resilience (the ability to bounce back after adversity), so important in the human field, has not been specifically studied in this species. This study examined the validity of this concept in dogs, through the development of a reliable instrument to measure resilience as a trait and a subsequent assessment of its psychometric properties. A survey was developed and distributed online to dog owners. Items covered demographic factors and the presence of problem behaviours, as well as 19 items related to three domains of resilience described in the human literature, which might reflect trait-level resilience in dogs. Here, 1084 completed responses were returned, and 329 dog owners completed the survey a second time 6–8 weeks later to assess intra-rater reliability. An analysis of the structure of the resilience items was performed on those found reliable. This revealed a two-component solution, one reflecting “Adaptability/behavioural flexibility” and the other “Perseverance”, which are in line with two aspects of the human conceptualisation of resilience. Good agreement was found with expected correlates, such as problem behaviour, enhancing the validity of this scale for the assessment of resilience in dogs. Abstract The concept of psychological resilience is well-explored in the human literature and is often described as the ability to ‘bounce back’ following adversity. However, it remains a neglected research area in dogs despite observations that like humans, dogs vary in their ability to cope with stress. This study aimed to develop the first canine ‘resilience’ scale. An on-line survey was developed for owners. This covered demographics, medical/behavioural history of the dog, and 19 potential resilience items assessed using a 5-point Likert scale; 1084 complete responses were received during the survey period, with 329 respondents subsequently completing the questionnaire a second time, 6–8 weeks later. Intra-rater reliability was assessed, and only reliable items retained. A principal component analysis (PCA) with varimax rotation was then performed with components extracted on the basis of the inspection of scree plots and the Kaiser criterion. Items were retained if they loaded >0.4 onto one of the components but removed if they cross-loaded onto more than one component. This resulted in a 14-item, 2-component solution. One component appeared to describe “Adaptability/behavioural flexibility” and the other “Perseverance”, which are described in the human literature on resilience. Predictive validity was established for expected correlates, such as problem behaviour. The resulting instrument was called the Lincoln Canine Adaptability and Resilience Scale (L-CARS) and is the first to be developed for the assessment of resilience in dogs.
The prognostic and clinicopathological significance of SLC7A11 in human cancers: a systematic review and meta-analysis

Objective It is of great importance to recognize bio-markers for cancer prognosis. However, the association between solute carrier family 7 member 11 (SLC7A11) and prognosis is still controversial. Therefore, we conducted this systematic review and meta-analysis to identify the prognostic and clinicopathological significance of SLC7A11 in human cancers. Methods PubMed, Web of Science, Scopus, the Cochrane Library and Embase database were searched from database inceptions to March 19th 2022. Hand searches were also conducted in references. Prognosis and clinicopathological data were extracted and analyzed. Results A total of 12 eligible studies with 1,955 patients were included. The results indicated that SLC7A11 expression is associated with unfavorable overall survival (OS), unfavorable recurrence-free survival (RFS) and unfavorable progression free survival (PFS). And SLC7A11 expression is also associated with more advanced tumor stage. Conclusions SLC7A11 expression is associated with more unfavorable prognosis and more advanced tumor stage. Therefore, SLC7A11 could be a potential biomarker for human cancer prognosis.
Search Algorithms for the Combinatorial Generation of Bordered Box Repetition-Free Words

Four search algorithms to search for the longest box repetition-free word over a given alphabet are presented, giving an empirical result on the upper bound of the length of these words. A box repetition-free word is a finite word w where any given factor of the form asa, with a ∈ Σ and s ∈ Σ∗, occurs at most once. A maximal box repetition-free word is a box repetition-free word which cannot be extended by appending to it any a ∈ Σ without it ceasing to be repetition free.
The Unmet Needs for Studying Chronic Pelvic/Visceral Pain Using Animal Models

The different definitions of chronic pelvic/visceral pain used by international societies have changed over the years. These differences have a great impact on the way researchers study chronic pelvic/visceral pain. Recently, the role of systemic changes, including the role of the central nervous system, in the perpetuation and chronification of pelvic/visceral pain has gained weight. Consequently, researchers are using animal models that resemble those systemic changes rather than using models that are organ- or tissue-specific. In this review, we discuss the advantages and disadvantages of using bladder-centric and systemic models, enumerating some of the central nervous system changes and pain-related behaviors occurring in each model. We also present some drawbacks when using animal models and pain-related behavior tests and raise questions about possible, yet to be demonstrated, investigator-related bias. We also suggest new approaches to study chronic pelvic/visceral pain by refining existing animal models or using new ones.
Inertial versus baroclinic instability of the Bickley jet in continuously stratified rotating fluid

Abstract The paper contains a detailed study of the inertial instability of a barotropic Bickley jet on the $f$ -plane in the continuously stratified primitive equations model, and a comparison of this essentially ageostrophic instability with the classical baroclinic one. Analytical and numerical investigation of the linear stability of the jet in the long-wave sector is performed for a range of Rossby and Burger numbers. The major results are that: (1) the standard symmetric inertial instability, appearing at high enough Rossby numbers, turns out to be the infinite-wavelength limit of an asymmetric inertial instability, this latter having the highest growth rate for a large range of vertical wavenumbers; (2) inertial instability coexists with the standard baroclinic instability, which becomes dominant at small Rossby numbers. Nonlinear saturation of the inertial instability of the jet with a superimposed random small-amplitude perturbation is then studied, using the Weather Research and Forecast model. It is shown that at first stages the inertial instability dominates. It is localized near the maximum of the anticyclonic shear and is associated with the highest attainable value of the vertical wavenumber. The saturation of the inertial instability leads to the homogenization of the geostrophic momentum in the unstable region. At later stages, another baroclinic instability develops, characterized by lower values of the vertical wavenumber. This instability saturates by forming large-scale vortices downstream. It is identified as the leading instability of a marginally inertially stable jet resulting from the initial one through homogenization of the geostrophic momentum. The rough scenario of the evolution of essentially ageostrophic jets is, thus, as follows: the inertial instability rapidly saturates and baroclinic instability takes over. It is shown that reorganization of the flow due to developing instabilities is an efficient source of inertia-gravity waves.
Rayleigh behaviour and the threshold field in ferroelectric ceramics

Abstract The threshold field, Et, values for various barium titanate and PZT-based ceramics have been determined by examination of the er |-E 0 and er ∥-E 0 relationships. The results obtained for both ‘soft’ and ’hard’ PZT ceramics gave a good fit to the Rayleigh Law over a wide range of field amplitude for E 0 E t. The linear increases in er | and er ∥ as a function of field amplitude were attributed to a lossy ferroelectric domain wall translation mechanism, by analogy with similar behaviour in ferromagnetic materials. At high field levels approaching the coercive field, E c, the measured er |-E 0 and er ∥-E 0 curves deviated from a linear relationship due to the onset of partial ferroelectric domain switching. Pure and Mn-doped barium titanate ceramics exhibited nonlinear er |-E 0 and er ∥-E 0 plots with a gradually increasing gradient. However, all of the materials studied yielded a linear er | and er ∥ relationship, from which a critical field for the initiation of ferroelectric domain switching, E .
Making statistical data more available

Les bureaux des statistiques, peuvent-ils repondre aux demandes des utilisateurs de rendre les donnes statistiques plus accessible par les technologies modemes? Peuvent-ils le faire sous les restrictions imposees par le budget et par l'interet des repondants? Ce sont des questions adressees ici. Les problemes et les possibilites sont illustres par des exemples de la Suede.
Two-dimensional airfoil shape optimization for airfoils at low speeds

This paper presents a fast methodology for the design of two-dimensional low-speed airfoils. We propose a methodology in which the design process starts from an already known airfoil or from a new defined airfoil by imposing some basic geometrical characteristics, such as: the airfoil’s radius at the leading edge, the maximum height of the airfoil’s lower and upper sides, the slopes of the airfoil’s defining curves at the trailing edge and the trailing edge gaps. Based on the above initial geometry the airfoil shape is further parameterized by use of Bezier or Bspline curves, the relative merit of the two types of parameterization is carefully analyzed and exemplified in the results section. The control points of the defining curves can be used to optimize the shape of the airfoil. The Xfoil flow solver was used for the aerodynamical calculations, and Matlab’s fmincon was used as the optimizer.
Impact of Lanthanum-Induced Dipoles on the Tunneling and Dielectric Properties of Gate-Stack

Threshold voltage (<inline-formula> <tex-math notation="LaTeX">${V_{t}}$ </tex-math></inline-formula>) engineering is critical and challenging in the advanced logic devices. Inducing interface dipoles by the incorporation of dopants into the gate dielectrics is an emerging scheme to modulate the threshold voltage. However, the impact of those dipoles on gate-stack performance is of great concern. In this work, we present the first-principles calculations of dielectric constant and tunneling current of high-<inline-formula> <tex-math notation="LaTeX">${k}$ </tex-math></inline-formula> gate-stack with lanthanum (La) dopants. It is found that incorporation of La improves the local dielectric constant as well as the equivalent oxide thickness (EOT), but degrades the gate leakage current. The calculated results are consistent with the reported experimental data. Furthermore, by analyzing the transmission coefficients and band alignment across the gate-stack, a theoretical explanation for the change of gate leakage current is provided.