Miracle-dz/UniFAR-FTUs huggingface dataset:
Epigenetic transgenerational inheritance of altered stress responses

Ancestral environmental exposures have previously been shown to promote epigenetic transgenerational inheritance and influence all aspects of an individual’s life history. In addition, proximate life events such as chronic stress have documented effects on the development of physiological, neural, and behavioral phenotypes in adulthood. We used a systems biology approach to investigate in male rats the interaction of the ancestral modifications carried transgenerationally in the germ line and the proximate modifications involving chronic restraint stress during adolescence. We find that a single exposure to a common-use fungicide (vinclozolin) three generations removed alters the physiology, behavior, metabolic activity, and transcriptome in discrete brain nuclei in descendant males, causing them to respond differently to chronic restraint stress. This alteration of baseline brain development promotes a change in neural genomic activity that correlates with changes in physiology and behavior, revealing the interaction of genetics, environment, and epigenetic transgenerational inheritance in the shaping of the adult phenotype. This is an important demonstration in an animal that ancestral exposure to an environmental compound modifies how descendants of these progenitor individuals perceive and respond to a stress challenge experienced during their own life history.
A 24-mW 28-Gb/s wireline receiver with low-frequency equalizing CTLE and 2-tap speculative DFE

In this paper, a power-efficient equalization techniques is proposed for a high data-rate multi-standard wireline receiver. First, a low-frequency-equalizing continuous-time linear equalizer (LFE-CTLE) compensates for not only the short-term inter-symbol interference (ISI) from high-frequency channel loss but also the long-term ISI from the low-frequency channel loss without additional power consumption compared to the previous CTLE. LFE-CTLE can reduce the required number of taps and power consumption of the following decision feedback equalizer (DFE). A 2-tap speculative DFE adopts 4-phase clocking techniques to reduce the number of summation nodes and latches for low-power consumption. The proposed receiver is designed in 65-nm LP CMOS technology with 1. -2V supply voltage. It can achieve 28-Gb/s data rate with a 24-mW power efficiency.
Modeling the ODP computational viewpoint with UML 2.0

The ODP computational viewpoint describes the functionality of a system and its environment in terms of a configuration of objects interacting at interfaces, independently of their distribution. Up until UML version 2.0, both the lack of precision in the UML definition and the semantic gap between the ODP concepts and the UML constructs hindered its application for ODP computational viewpoint modeling. With the advent of UML 2.0 the situation may have changed, because its semantics have been more precisely defined and it now incorporates a whole new set of concepts more apt for modeling the structure and behavior of distributed systems. In this paper, we explore the benefits provided by the new extension mechanisms of UML and, more specifically, we present a UML profile for modeling the ODP computational viewpoint concepts. We also show a case study that illustrates how our proposal is applied to a multimedia distributed system.
Participatory design workshops to evaluate multimodal applications

In this paper we present our approach to the evaluation of multimodal applications by using participatory design workshops. Our goal is to obtain user feedback for our design on a fundamental, conceptual level. We propose in this paper the use of design ideas coming from the users, not only by translating them one-to-one into design but also by analyzing them in order to reflect on the design concepts behind the artifacts being constructed. By providing examples of workshops conducted, we show a methodology that helps in exploring the design space and that has the potential of producing more interesting jumps inside the design space, towards more a satisfying user experience.
Country Differences and Changes in Focus of Scientific Tobacco Control Publications between 2000 and 2012 in Europe

Background/Aims: The Framework Convention on Tobacco Control (FCTC) stresses the importance of scientific research. We examined the differences between 31 European countries regarding quantity and focus of tobacco control research publications. Methods: PubMed, Web of Science, Scopus, and PsycInfo were searched for peer-reviewed articles on tobacco, written by European authors, published between 2000 and 2012. For 2000, 2004, 2008, and 2012 we further identified the main focus of the publication. Results: The volume of European tobacco control scientific publications had almost doubled. Scandinavian countries had most publications per inhabitant, while Bulgaria, Cyprus, Estonia, Latvia, Lithuania, Malta, Romania, Slovakia, and Slovenia had relatively little research output. There was a smaller increase in publications about harm from tobacco, relative to publications about treatment, and education, and to publications about environmental interventions. In 2012, 49% of all publications were about health, while the total number of publications on environmental interventions was relatively small (10%). Conclusion: Research output had almost doubled, in line with global trends, but is still unevenly distributed across Europe. Although we observed a shift in European publications away from the harm of tobacco towards protecting smokers and changing the environment, the field is still dominated by publications on smoking and health.
A Field Guide to the Reptiles of South-East Asia

This beautiful and indispensable handbook will appeal to the expert and amateur alike. Offering a wealth of information on identifying nearly 400 of the most commonly encountered garden wildlife in Britain and Northern Europe, each species is clearly described with informed and concise text and an easy-to-follow layout for quick identification. Detailed colour artworks accompany the accessible and engaging text, making this guide a wonderful addition to any book shelf.Other titles in "New Holland's The Wildlife Trusts" series are: "Guide to Garden Wildlife", "Birds", "Butterflies & Moths", "Insects", "Trees", and "Wild Flowers".
Creating the Open Wordnet Bahasa

This paper outlines the creation of the Wordnet Bahasa as a resource for the study of lexical semantics in the Malay language. It is created by combining information from several lexical resources: the French-English-Malay dictionary FEM, the KAmus Melayu- Inggeris KAMI, and wordnets for English, French and Chinese. Construction went through three steps: (i) automatic building of word candidates; (ii ) evaluation and selection of accept- able candidates from merging of lexicons; (iii) final hand ch eck of the 5,000 core synsets. Our Wordnet Bahasa is only in the first phase of building a full fledged wordNet and needs to be further expanded, however it is already large enough to be useful for sense tagging both Malay and Indonesian.
Myths about Congestion Management in High Speed Networks

Weaknesses in several recently proposed ideas about congestion control and avoidance in high-speed netwroks are identified. Both sides of the debate concerning prior reservation of resources versus walk-in service, open-loop control versus feedback control, rate control versus window control, and router-based control versus source-based control are presented. The circumstances under which backpressure is useful or not are discussed, and it is argued that a single congestion scheme is not sufficient, but that a combination of several schemes is required for complete congestion management in a network.
Early glycemic control reduces large-for-gestational-age infants in 250 Japanese gestational diabetes pregnancies.

Our objective was to test if tight glycemic control versus loose glycemic control in gestational diabetic patients and a gestational age of < 32 weeks influence fetal growth, fetal distress, and neonatal complication. We performed a retrospective study with 250 gestational diabetes mellitus in Japanese women. Two groups were categorized according to the timing at which good maternal glycemic control was attained at < 32 weeks and kept so until delivery (group 1) and > 32 weeks or never until delivery (group 2). In these two groups, neonatal growth (large-for-gestational age: LGA; appropriate- : AGA; and small- : SGA), neonatal complications (hypoglycemia, jaundice, polycythemia, and cumulative incidence), and incidence of fetal distress were compared. The chi2 test, unpaired t test, one-way analysis of variance (ANOVA) and multiple logistic regression analyses were used for statistical analyses. Maternal age, height, prepregnancy body mass index (BMI), gestational age at delivery were not different between the groups. In group 2 (> 32 weeks), LGA, macrosomia (> 4 kg), neonatal hypoglycemia was significantly increased compared with those in group 1. Incidence of SGA, fetal distress, and neonatal jaundice were not different between the groups. Multiple logistic regression analysis for LGA showed significant relation to timing of maternal glycemic control. We concluded that good glycemic control should be attained at < 32 weeks and maintained until delivery to reduce LGA infants and neonatal hypoglycemia in gestational diabetes mellitus. This management did not appear to decrease SGA infants or fetal distress.
Robust activity recognition combining anomaly detection and classifier retraining

Activity recognition systems based on body-worn motion sensors suffer from a decrease in performance during the deployment and run-time phases, because of probable changes in the sensors (e.g. displacement or rotatation), which is the case in many real-life scenarios (e.g. mobile phone in a pocket). Existing approaches to achieve robustness tend to sacrifice information (e.g. by rotation-invariant features) or reduce the weight of the anomalous sensors at the classifier fusion stage (adaptive fusion), ignoring data which might still be perfectly meaningful, although different from the training data. We propose to use adaptation to rebuild the classifier models of the sensors which have changed position by a two-step approach: in the first step, we run an anomaly detection algorithm to automatically detect which sensors are delivering unexpected data; subsequently, we trigger a system self-training process, so that the remaining classifiers retrain the “anomalous” sensors. We show the benefit of this approach in a real activity recognition dataset comprising data from 8 sensors to recognize locomotion. The approach achieves similar accuracy compared to the upper baseline, obtained by retraining the anomalous classifiers on the new data.
A Greedy Scanning Data Collection Strategy for Large-Scale Wireless Sensor Networks with a Mobile Sink

Mobile sink is widely used for data collection in wireless sensor networks. It can avoid ‘hot spot’ problems but energy consumption caused by multihop transmission is still inefficient in real-time application scenarios. In this paper, a greedy scanning data collection strategy (GSDCS) is proposed, and we focus on how to reduce routing energy consumption by shortening total length of routing paths. We propose that the mobile sink adjusts its trajectory dynamically according to the changes of network, instead of predetermined trajectory or random walk. Next, the mobile sink determines which area has more source nodes, then it moves toward this area. The benefit of GSDCS is that most source nodes are no longer needed to upload sensory data for long distances. Especially in event-driven application scenarios, when event area changes, the mobile sink could arrive at the new event area where most source nodes are located currently. Hence energy can be saved. Analytical and simulation results show that compared with existing work, our GSDCS has a better performance in specific application scenarios.
Conserved T Cell Receptor Repertoire in Primary and Memory CD8 T Cell Responses to an Acute Viral Infection

Viral infections often induce potent CD8 T cell responses that play a key role in antiviral immunity. After viral clearance, the vast majority of the expanded CD8 T cells undergo apoptosis, leaving behind a stable number of memory cells. The relationship between the CD8 T cells that clear the acute viral infection and the long-lived CD8 memory pool remaining in the individual is not fully understood. To address this issue, we examined the T cell receptor (TCR) repertoire of virus-specific CD8 T cells in the mouse model of infection with lymphocytic choriomeningitis virus (LCMV) using three approaches: (a) in vivo quantitative TCR β chain V segment and complementarity determining region 3 (CDR3) length repertoire analysis by spectratyping (immunoscope); (b) identification of LCMV-specific CD8 T cells with MHC class I tetramers containing viral peptide and costaining with TCR Vβ–specific antibodies; and (c) functional TCR fingerprinting based on recognition of variant peptides. We compared the repertoire of CD8 T cells responding to acute primary and secondary LCMV infections, together with that of virus-specific memory T cells in immune mice. Our analysis showed that CD8 T cells from several Vβ families participated in the anti-LCMV response directed to the dominant cytotoxic T lymphocyte (CTL) epitope (NP118–126). However, the bulk (∼70%) of this CTL response was due to three privileged T cell populations systematically expanding during LCMV infection. Approximately 30% of the response consisted of Vβ10+ CD8 T cells with a β chain CDR3 length of nine amino acids, and 40% consisted of Vβ8. 1+ (β CDR3 = eight amino acids) and Vβ8. 2+ cells (β CDR3 = six amino acids). Finally, we showed that the TCR repertoire of the primary antiviral CD8 T cell response was similar both structurally and functionally to that of the memory pool and the secondary CD8 T cell effectors. These results suggest a stochastic selection of memory cells from the pool of CD8 T cells activated during primary infection.
In Vitro Activation of the IκB Kinase Complex by Human T-cell Leukemia Virus Type-1 Tax*

Human T-cell leukemia virus type-I expresses Tax, a 40-kDa oncoprotein that activates IκB kinase (IKK), resulting in constitutive activation of NFκB. Herein, we have developed an in vitro signaling assay to analyze IKK complex activation by recombinant Tax. Using this assay in combination with reporter assays, we demonstrate that Tax-mediated activation of IKK is independent of phosphatases. We show that sustained activation of the Tax-mediated activation of the NFκB pathway is dependent on an intact Hsp90-IKK complex. By acetylating and thereby preventing activation of the IKK complex by the Yersinia effector YopJ, we demonstrate that Tax-mediated activation of the IKK complex requires a phosphorylation step. Our characterization of an in vitro signaling assay system for the mechanism of Tax-mediated activation of the IKK complex with a variety of mutants and inhibitors results in a working model for the biochemical mechanism of Tax-induced activation.
Concurrent Bursty Behavior of Social Sensors in Sporting Events

The advent of social media expands our ability to transmit information and connect with others instantly, which enables us to behave as “social sensors. ” Here, we studied concurrent bursty behavior of Twitter users during major sporting events to determine their function as social sensors. We show that the degree of concurrent bursts in tweets (posts) and retweets (re-posts) works as a strong indicator of winning or losing a game. More specifically, our simple tweet analysis of Japanese professional baseball games in 2013 revealed that social sensors can immediately react to positive and negative events through bursts of tweets, but that positive events are more likely to induce a subsequent burst of retweets. We confirm that these findings also hold true for tweets related to Major League Baseball games in 2015. Furthermore, we demonstrate active interactions among social sensors by constructing retweet networks during a baseball game. The resulting networks commonly exhibited user clusters depending on the baseball team, with a scale-free connectedness that is indicative of a substantial difference in user popularity as an information source. While previous studies have mainly focused on bursts of tweets as a simple indicator of a real-world event, the temporal correlation between tweets and retweets implies unique aspects of social sensors, offering new insights into human behavior in a highly connected world.
SLEEP PATTERNS IN MILITARY PERSONNEL Sleep Patterns Before , During , and After Deployment to Iraq and Afghanistan

1615 Sleep Patterns and Deployment to Iraq and Afghanistan—Seelig et al ACCORDING TO A 2008 REPORT FROM THE NATIONAL SLEEP FOUNDATION, AMERICANS ARE WORKING MORE AND SLEEPING LESS, WITH THE AVERAGE work day lasting 9 hours 28 minutes and time in bed only 6 hours 55 minutes.1 The US military is at particularly high risk for sleep disturbances due to hazardous working conditions, inconsistent work hours, harsh environments, routine exposure to loud noises, and crowded sleeping spaces.2,3 Exposures to these adverse working conditions are often intensified during deployments, including the current increased operational tempo, with lengthy and frequent deployments, as well as demanding training exercises. Deployment-related factors may lead to sleep complaints, including circadian desynchronosis, total or partial sleep deprivation, lengthy sleep latency, and wakening after sleep onset that may, in turn, exacerbate mental and physical health symptoms following deployment.2,3 The quantity and quality of sleep affect many aspects of physical and mental health.4-12 Military personnel deployed in support of Operation Iraqi Freedom and Operation Enduring Freedom may be at increased risk for chronic sleep loss, as well as many other adverse physical and mental conditions, compared with nondeployed military personnel.13-15 Sleep deprivation has been studied extensively and is associated with many physical and psychological effects, including increased risk-taking behavior,7,11 decreased threat detection,10 impaired decision making,7,11,12 performance degradation,4,8,9 mood disturbances,8 and tunnel vision.6 Short sleep duration has also been associated with obesity, weight gain, and heart disease.5,16,17 A recent cross-sectional study of 156 deployed US Air Force Airmen found that 40% of respondents suffered from at least 1 sleep disturbance, and 75% of respondents reported diminished sleep quality while deployed when compared to sleep quality at home.3 The purpose of this study was to determine any association between deployment in support of the operations in Iraq and Afghanistan and sleep quantity and quality in a large military population. We hypothesized that military personnel who had deployed would have more trouble sleeping and sleep less than those who have not deployed. The Millennium Cohort Study18 includes all Service branches of the US military, activeduty, Reserve, and National Guard personnel. A substantial proportion (22%) of cohort members were deployed in support of the operations in Iraq and Afghanistan between baseline and SLEEP PATTERNS IN MILITARY PERSONNEL
Lagrangian Relaxation and Partial Cover (Extended Abstract)

Lagrangian relaxation has been used extensively in the design of approximation algorithms. This paper studies its strengths and limitations when applied to Partial Cover. We show that for Partial Cover in general no algorithm that uses Lagrangian relaxation and a Lagrangian Multiplier Preserving (LMP) $alpha$-approximation as a black box can yield an approximation factor better than~$frac{4}{3} alpha$. This matches the upper bound given by K"onemann et al. (ESA 2006, pages 468--479). Faced with this limitation we study a specific, yet broad class of covering problems: Partial Totally Balanced Cover. By carefully analyzing the inner workings of the LMP algorithm we are able to give an almost tight characterization of the integrality gap of the standard linear relaxation of the problem. As a consequence we obtain improved approximations for the Partial version of Multicut and Path Hitting on Trees, Rectangle Stabbing, and Set Cover with $ ho$-Blocks.
Axially Elongated Field-Free Point Data Acquisition in Magnetic Particle Imaging

The magnetic particle imaging (MPI) technology is a new imaging technique featuring an excellent possibility to detect iron oxide based nanoparticle accumulations in vivo. The excitation of the particles and in turn the signal generation in MPI are achieved by using oscillating magnetic fields. In order to realize a spatial encoding, a field-free point (FFP) is steered through the field of view (FOV). Such a positioning of the FFP can thereby be achieved by mechanical or electromagnetical movement. Conventionally, the data acquisition path is either a planar 2-D or a 3-D FFP trajectory. Assuming human applications, the size of the FOV sampled by such trajectories is strongly limited by heating of the body and by nerve stimulations. In this work, a new approach acquiring MPI data based on the axial elongation of a 2-D FFP trajectory is proposed. It is shown that such an elongation can be used as a data acquisition path to significantly increase the acquisition speed, with negligible loss of spatial resolution.
A Wall of Funnels Concentrates Swimming Bacteria

ABSTRACT Randomly moving but self-propelled agents, such as Escherichia coli bacteria, are expected to fill a volume homogeneously. However, we show that when a population of bacteria is exposed to a microfabricated wall of funnel-shaped openings, the random motion of bacteria through the openings is rectified by tracking (trapping) of the swimming bacteria along the funnel wall. This leads to a buildup of the concentration of swimming cells on the narrow opening side of the funnel wall but no concentration of nonswimming cells. Similarly, we show that a series of such funnel walls functions as a multistage pump and can increase the concentration of motile bacteria exponentially with the number of walls. The funnel wall can be arranged along arbitrary shapes and cause the bacteria to form well-defined patterns. The funnel effect may also have implications on the transport and distribution of motile microorganisms in irregular confined environments, such as porous media, wet soil, or biological tissue, or act as a selection pressure in evolution experiments.