Miracle-dz/UniFAR-FTUs huggingface dataset:
On the Sunyaev-Zel'dovich effect from dark matter annihilation or decay in galaxy clusters

We revisit the prospects for detecting the Sunyaev Zel'dovich (SZ) effect induced by dark matter (DM) annihilation or decay. We show that with standard (or even extreme) assumptions for DM properties, the optical depth associated with relativistic electrons injected from DM annihilation or decay is much smaller than that associated with thermal electrons, when averaged over the angular resolution of current and future experiments. For example, we find: τDM ~ 10−9−10−5 (depending on the assumptions) for mχ = 1 GeV and a density profile ρ∝r−1 for a template cluster located at 50 Mpc and observed within an angular resolution of 10'', compared to τth ~ 10−3−10−2. This, together with a full spectral analysis, enables us to demonstrate that, for a template cluster with generic properties, the SZ effect due to DM annihilation or decay is far below the sensitivity of the Planck satellite. This is at variance with previous claims regarding heavier annihilating DM particles. Should DM be made of lighter particles, the current constraints from 511 keV observations on the annihilation cross section or decay rate still prevent a detectable SZ effect. Finally, we show that spatial diffusion sets a core of a few kpc in the electron distribution, even for very cuspy DM profiles, such that improving the angular resolution of the instrument, eg with ALMA, does not necessarily improve the detection potential. We provide useful analytical formulae parameterized in terms of the DM mass, decay rate or annihilation cross section and DM halo features, that allow quick estimates of the SZ effect induced by any given candidate and any DM halo profile.
SOI-FET Sensors with Dielectrophoretic Concentration of Viruses and Proteins

Quick label-free virus screening and highly sensitive analytical tools/techniques are becoming extremely important in a pandemic. In this study, we developed a biosensing device based on the silicon nanoribbon multichannel and dielectrophoretic controlled sensors functionalized with SARS-CoV-2 spike antibodies for the use as a platform for the detection and studding of properties of viruses and their protein components. Replicatively defective viral particles based on vesicular stomatitis viruses and HIV-1 were used as carrier molecules to deliver the target SARS-CoV-2 spike S-proteins to sensory elements. It was shown that fully CMOS-compatible nanoribbon sensors have the subattomolar sensitivity and dynamic range of 4 orders. Specific interaction between S-proteins and antibodies leads to the accumulation of the negative charge on the sensor surface. Nonspecific interactions of the viral particles lead to the positive charge accumulation. It was shown that dielectrophoretic controlled sensors allow to estimate the effective charge of the single virus at the sensor surface and separate it from the charge associated with the binding of target proteins with the sensor surface.
Droplet Microfluidics Enables Tracing of Target Cells at the Single-Cell Transcriptome Resolution

The rapid promotion of single-cell omics in various fields has begun to help solve many problems encountered in research, including precision medicine, prenatal diagnosis, and embryo development. Meanwhile, single-cell techniques are also constantly updated with increasing demand. For some specific target cells, the workflow from droplet screening to single-cell sequencing is a preferred option and should reduce the impact of operation steps, such as demulsification and cell recovery. We developed an all-in-droplet method integrating cell encapsulation, target sorting, droplet picoinjection, and single-cell transcriptome profiling on chips to achieve labor-saving monitoring of TCR-T cells. As a proof of concept, in this research, TCR-T cells were encapsulated, sorted, and performed single-cell transcriptome sequencing (scRNA-seq) by injecting reagents into droplets. It avoided the tedious operation of droplet breakage and re-encapsulation between droplet sorting and scRNA-seq. Moreover, convenient device operation will accelerate the progress of chip marketization. The strategy achieved an excellent recovery performance of single-cell transcriptome with a median gene number over 4000 and a cross-contamination rate of 8.2 ± 2%. Furthermore, this strategy allows us to develop a device with high integrability to monitor infused TCR-T cells, which will promote the development of adoptive T cell immunotherapy and their clinical application.
Very Long Baseline Array Imaging of Type-2 Seyferts with Double-peaked Narrow Emission Lines: Searches for Sub-kpc Dual AGNs and Jet-powered Outflows

This paper presents Very Long Baseline Array (VLBA) observations of 13 double-peaked [O iii] emission-line type-2 active galactic nuclei (AGNs) at redshifts 0.06 < z < 0.41 (with a median redshift of z ∼ 0.15) identified in the Sloan Digital Sky Survey. Such double-peaked emission-line objects may result from jets or outflows from the central engine or from a dual AGN. The VLBA provides an angular resolution of ≲10 pc at the distance of many of these galaxies, sufficient to resolve the radio emission from extremely close dual AGNs and to contribute to understanding the origin of double-peaked [O iii] emission lines. Of the 13 galaxies observed at 3.6 cm (8.4 GHz), we detect six at a 1σ sensitivity level of ∼0.15 mJy beam−1, two of which show clear jet structures on scales ranging from a few milliarcseconds to tens of milliarcseconds (corresponding to a few pc to tens of pc at a median redshift of 0.15). We suggest that radio-loud, double-peaked emission-line type-2 AGNs may be indicative of jet produced structures, but a larger sample of double-peaked [O iii] AGNs with high angular resolution radio observations will be required to confirm this suggestion.
BIPS—A code base for designing and coding of a Phage ImmunoPrecipitation Oligo Library

BIPS (Build Phage ImmunoPrecipitation Sequencing library) is a software that converts a list of proteins into a custom DNA oligonucleotide library for the PhIP-Seq system. The tool creates constant-length oligonucleotides with internal barcodes, while maintaining the original length of the peptide. This allows using large libraries, of hundreds of thousands of oligonucleotides, while saving on the costs of sequencing and maintaining the accuracy of oligonucleotide reads identification. BIPS is available under GNU public license from: https://github.com/kalkairis/BuildPhIPSeqLibrary.
SPIN-DOWN DYNAMICS OF MAGNETIZED SOLAR-TYPE STARS

It has long been known that solar-type stars undergo significant spin-down, via magnetic braking, during their main-sequence lifetimes. However, magnetic braking only operates on the surface layers; it is not yet completely understood how angular momentum is transported within the star and how rapidly the spin-down information is communicated to the deep interior. In this work, we use insight from recent progress in understanding internal solar dynamics to model the interior of other solar-type stars. We assume, following Gough & McIntyre, that the bulk of the radiation zone of these stars is held in uniform rotation by the presence of an embedded large-scale primordial field, confined below a stably stratified, magnetic-free tachocline by large-scale meridional flows downwelling from the convection zone. We derive simple equations to describe the response of this model interior to spin-down of the surface layers, which are identical to the two-zone model of MacGregor & Brenner, with a coupling timescale proportional to the local Eddington–Sweet timescale across the tachocline. This timescale depends both on the rotation rate of the star and on the thickness of the tachocline, and it can vary from a few hundred thousand years to a few Gyr, depending on stellar properties. Qualitative predictions of the model appear to be consistent with observations, although they depend sensitively on the assumed functional dependence of the tachocline thickness on the stellar rotation rate.
Irreversible mixing by unstable periodic orbits in buoyancy dominated stratified turbulence

We consider turbulence driven by a large-scale horizontal shear in Kolmogorov flow (i.e. with sinusoidal body forcing) and a background linear stable stratification with buoyancy frequency $N_{B}^{2}$ imposed in the third, vertical direction in a fluid with kinematic viscosity $\unicode[STIX]{x1D708}$ . This flow is known to be organised into layers by nonlinear unstable steady states, which incline the background shear in the vertical and can be demonstrated to be the finite-amplitude saturation of a sequence of instabilities, originally from the laminar state. Here, we investigate the next order of motions in this system, i.e. the time-dependent mechanisms by which the density field is irreversibly mixed. This investigation is achieved using ‘recurrent flow analysis’. We identify (unstable) periodic orbits, which are embedded in the turbulent attractor, and use these orbits as proxies for the chaotic flow. We find that the time average of an appropriate measure of the ‘mixing efficiency’ of the flow $\mathscr{E}=\unicode[STIX]{x1D712}/(\unicode[STIX]{x1D712}+{\mathcal{D}})$ (where ${\mathcal{D}}$ is the volume-averaged kinetic energy dissipation rate and $\unicode[STIX]{x1D712}$ is the volume-averaged density variance dissipation rate) varies non-monotonically with the time-averaged buoyancy Reynolds numbers $\overline{Re}_{B}=\overline{{\mathcal{D}}}/(\unicode[STIX]{x1D708}N_{B}^{2})$ , and is bounded above by $1/6$ , consistently with the classical model of Osborn (J. Phys. Oceanogr., vol. 10 (1), 1980, pp. 83–89). There are qualitatively different physical properties between the unstable orbits that have lower irreversible mixing efficiency at low $\overline{Re}_{B}\sim O(1)$ and those with nearly optimal $\mathscr{E}\lesssim 1/6$ at intermediate $\overline{Re}_{B}\sim 10$ . The weaker orbits, inevitably embedded in more strongly stratified flow, are characterised by straining or ‘scouring’ motions, while the more efficient orbits have clear overturning dynamics in more weakly stratified, and apparently shear-unstable flow.
Danazol in Refractory Autoimmune Hemolytic Anemia or Immune Thrombocytopenia: A Case Series Report and Literature Review

Danazol is a treatment option for autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). Three patients with AIHA and eight patients with ITP between 2008 and 2022 were enrolled in the Rheumatology Outpatient Clinic of Chang Gung Memorial Hospital, Kaohsiung. Those patients were refractory or intolerant to conventional therapy and were treated with danazol. All the patients received an initial dose of danazol (200–400 mg). The observation period was 6 months. Three patients (100%) with AIHA and six (75%) with ITP achieved treatment response after 6 months of danazol therapy. The dose of glucocorticoid for responders could be reduced to ≤5 mg/day of prednisolone, and the immunosuppressants, except hydroxychloroquine and azathioprine for systemic lupus erythematosus, could be discontinued. Adverse events were acne in two (18.2%) patients and transient dose-related liver function impairment in one (9.1%) patient in the current series. Danazol therapy appears to be a favorable alternative for refractory AIHA and ITP by altering the erythrocyte membrane to resist osmotic lysis and protecting platelets against complement-mediated lysis. In this report, we also performed a literature review and searched the PubMed/Cochrane Library for articles published from 1984 to January 2022 on danazol therapy for patients with AIHA and ITP.
Dynamic Self-Supervised Teacher-Student Network Learning

Lifelong learning (LLL) represents the ability of an artificial intelligence system to learn successively a sequence of different databases. In this paper we introduce the Dynamic Self-Supervised Teacher-Student Network (D-TS), representing a more general LLL framework, where the Teacher is implemented as a dynamically expanding mixture model which automatically increases its capacity to deal with a growing number of tasks. We propose the Knowledge Discrepancy Score (KDS) criterion for measuring the relevance of the incoming information characterizing a new task when compared to the existing knowledge accumulated by the Teacher module from its previous training. The KDS ensures a light Teacher architecture while also enabling to reuse the learned knowledge whenever appropriate, accelerating the learning of given tasks. The Student module is implemented as a lightweight probabilistic generative model. We introduce a novel self-supervised learning procedure for the Student that allows to capture cross-domain latent representations from the entire knowledge accumulated by the Teacher as well as from novel data. We perform several experiments which show that D-TS can achieve the state of the art results in LLL while requiring fewer parameters than other methods.
Implications of bacteriological study in complicated and uncomplicated acute appendicitis.

Purpose Bacteriological sample in the presence of intraabdominal free fluid is necessary to adapt the antibiotherapy and to prevent the development of resistance. The aim was to evaluate the differences between uncomplicated (UAA) and complicated acute appendicitis (CAA) in terms of bacterial culture results and antibiotic resistance, and to evaluate the factors linked with CAA. Methods We performed a single-center, retrospective observational study of all consecutive patients who presented with appendicular peritonitis and underwent emergent surgery in a tertiary referral hospital in Brussels, Belgium, between January 2013 and December 2020. The medical history, parameters at admission, bacterial culture, antibiotic resistance, and postoperative outcomes of 268 patients were analyzed. UAA was considered catarrhal or phlegmonous inflammation of the appendix. CAA was considered gangrenous or perforated appendicitis. Results Positive microbiological cultures were significantly higher in the CAA group (68.2% vs. 53.4%). The most frequently isolated bacteria in UAA and CAA cultures were Escherichia coli (37.9% and 48.6%). Most observed resistances were against ampicillin (28.9% and 21.7%) and amoxicillin/clavulanic acid (16.4% and 10.5%) in UAA and CAA, respectively. A higher Charlson comorbidity index, an elevated white blood cell count, an open procedure, and the need for drainage were linked to CAA. Culture results, group of bacterial isolation, and most common isolated bacteria were not related to CAA. Conclusion CAA presented a higher rate of positive cultures with increased identification of gram-negative bacteria. Bacterial culture from the peritoneal liquid does not reveal relevant differences in terms of antibiotic resistance.
A New Recombinant Multiepitope Chimeric Protein of Leptospira interrogans Is a Promising Marker for the Serodiagnosis of Leptospirosis

The zoonotic disease leptospirosis is caused by pathogenic species of the genus Leptospira and was recently included in the list of Neglected Diseases by the World Health Organization. Leptospirosis burden is estimated to have over a million human cases and cause 60 thousand deaths annually, in addition to its economic impact and veterinary concern. The microscopic agglutination test (MAT), recommended by the World Health Organization, exhibits reduced sensitivity at the beginning of the disease, in addition to being technically difficult. New recombinant antigens are being pursued for rapid and specific serodiagnostic tests, especially in the initial phase of the disease, and chimeric multiepitope proteins are a strategy with a great potential to be implemented in serology. Based on previous subproteomic results, we designed a synthetic construct comprising 10 conserved leptospiral surface antigens, and the recombinant protein was purified and evaluated regarding its diagnostic potential. The protein termed rChi2 was recognized by antibodies in serum from patients both at the onset (MAT−) and in the convalescent (MAT+) phase in 75 and 82% of responders, respectively. In addition, rChi2 immunization in hamsters elicited a strong humoral response, and anti-rChi2 antibodies recognized several immobilized intact Leptospira species, validating its potential as an early, broad, and cross-reactive diagnostic test.
Orexinergic neurons in the hypothalami of an Asiatic lion, an African lion, and a Southeast African cheetah

Employing orexin‐A immunohistochemistry, we describe the distribution, morphology, and nuclear parcellation of orexinergic neurons within the hypothalami of an Asiatic lion (Panthera leo subsp. persica), an African lion (Panthera leo subsp. melanochaita), and a Southeast African cheetah (Acinonyx jubatus subsp. jubatus). In all three felids, the clustering of large, bipolar, and multipolar hypothalamic orexinergic neurons primarily follows the pattern observed in other mammals. The orexinergic neurons were found, primarily, to form three distinct clusters—the main, zona incerta, and optic tract clusters. In addition, large orexinergic neurons were observed in the ventromedial supraoptic region of the hypothalamus, where they are not typically observed in other species. As has been observed in cetartiodactyls and the African elephant, a cluster of small, multipolar orexinergic neurons, the parvocellular cluster, was observed in the medial zone of the hypothalamus in all three felids, although this parvocellular cluster has not been reported in other carnivores. In both subspecies of lions, but not the cheetah, potential orexin‐immunopositive neurons were observed in the paraventricular hypothalamic nucleus, supraoptic nucleus, the lateral part of the retrochiasmatic area, and the inner layer of the median eminence. The distribution and parcellation of orexinergic neurons in the hypothalami of the three felids studied appear to be more complex than observed in many other mammals and for the two subspecies of lion may be even more complex. These findings are discussed in terms of potential technical concerns, phylogenetic variations of this system, and potentially associated functional aspects of the orexinergic system.
Reply to “Comment on ‘Axion induced oscillating electric dipole moments’”

A recent paper of Flambaum, Roberts and Stadnik, [1], claims there is no induced oscillating electric dipole moment (OEDM), eg, for the electron, arising from the oscillating cosmic axion background via the anomaly. This claim is based upon the assumption that electric dipoles always be defined by their coupling to static (constant in time) electric fields. The relevant Feynman diagram, as computed by [1], then becomes a total divergence, and vanishes in momentum space. However, an OEDM does arise from the anomaly, coupled to time dependent electric fields. It shares the decoupling properties with the anomaly. The full action, in an arbitrary gauge, was computed in [2], [3]. It is nonvanishing with a time dependent outgoing photon, and yields physics, eg, electric dipole radiation of an electron immersed in a cosmic axion field.
Searching for the doubly-charged Higgs bosons in the Georgi-Machacek model at the electron-proton colliders

The Georgi-Machacek model is one of many beyond Standard Model scenarios with an extended scalar sector which can group under the custodial $\rm SU(2)_C$ symmetry. There are 5-plet, 3-plet and singlet Higgs bosons under the classification of such symmetry in addition to the Standard Model Higgs boson. In this paper, we study the prospects for detecting the doubly-charged Higgs boson ($\rm H_5^{\pm\pm}$) through the vector boson fusion production at the electron-proton (ep) colliders. We concentrate on our analysis through $\mu$-lepton pair production via pair of same-sign W bosons decay. The $\rm H_5^{\pm\pm}$ discovery potentials at the ep colliders are presented.
Improving Scale Equivalence by Increasing Access to Scale-Specific Information

Measures of the same phenomenon should produce the same results; this principle is fundamental because it allows for replication—the basis of science. Unfortunately, measures of a psychological construct in one language can often measure something a bit different in another language (i.e., low “scale equivalence”). Historically, the problem was thought to stem from insufficient knowledge of best-practice translation procedures. Yet solutions based on this diagnosis and their widespread adoption have not resolved the issue. In this article, we suggest that an additional problem might be insufficient information about the measure being translated. If so, low scale equivalence is a problem that translators and cross-cultural psychologists cannot solve on their own. We explore the possibility that measure-specific translation guides be created by original scale builders for the most widely used measures of important psychological constructs. We describe why such guides are needed, when they are needed, what they might look like, their feasibility, and next steps, providing a complete example guide and test case in a supplement concerning the Primals Inventory. In this article, we seek to spark discussion on translation practices happening behind the scenes and how greater transparency can improve scale equivalence, in the spirit of open science.
The Serpens filament at the onset of slightly supercritical collapse

The Serpens filament, as one of the nearest infrared dark clouds, is regarded as a pristine filament at a very early evolutionary stage of star formation. In order to study its molecular content and dynamical state, we mapped this filament in seven species: C18O, HCO+, HNC, HCN, N2H+, CS, and CH3OH. Among them, HCO+, HNC, HCN, and CS show self-absorption, while C18O is most sensitive to the filamentary structure. A kinematic analysis demonstrates that this filament forms a velocity-coherent (trans)sonic structure, a large part of which is one of the most quiescent regions in the Serpens cloud. Widespread C18O depletion is found throughout the Serpens filament. Based on the Herschel dust-derived H2 column density map, the line mass of the filament is 36–41 M⊙ pc−1, and its full width at half maximum is 0.17 ± 0.01 pc, while its length is ≈1.6 pc. The inner radial column density profile of this filament can be well fitted with a Plummer profile with an exponent of 2.2 ± 0.1, a scale radius of 0.018 ± 0.003 pc, and a central density of (4.0 ± 0.8) × 104 cm−3. The Serpens filament appears to be slightly supercritical. The widespread blue-skewed HNC and CS line profiles and HCN hyperfine line anomalies across this filament indicate radial infall in parts of the Serpens filament. C18O velocity gradients also indicate accretion flows along the filament. The velocity and density structures suggest that such accretion flows are likely due to a longitudinal collapse parallel to the filament’s long axis. Both the radial infall rate (~72 M⊙ Myr−1, inferred from HNC and CS blue-skewed profiles) and the longitudinal accretion rate (~10 M⊙ Myr−1, inferred from C18O velocity gradients) along the Serpens filament are lower than all previously reported values in other filaments. This indicates that the Serpens filament lies at an early evolutionary stage when collapse has just begun, or that thermal and nonthermal support are effective in providing support against gravity.
Spectral density of random graphs with topological constraints

The spectral density of random graphs with topological constraints is analysed using the replica method. We consider graph ensembles featuring generalized degree–degree correlations, as well as those with a community structure. In each case, a formal exact solution is found for the spectral density in the form of consistency equations depending on the statistical properties of the graph ensemble in question. We highlight the effect of these topological constraints on the resulting spectral density.