Miracle-dz/UniFAR-FTUs huggingface dataset:
Field Study in the US 2 . 1 An Embedded Wizard of Oz Interface

Natural language speech enabled interfaces offer a compelling choice of user interaction for the automotive market. Such interfaces demand only a basic understanding of the system model instead of memorizing keywords and predefined patterns. To utilize natural language interfaces optimally, designers need to better comprehend how people communicate their requests to express their intentions and what expectations they have from the interaction experience. Empirical studies are needed to obtain such knowledge. In this paper we describe the design and undertaking of field studies in the US, discuss design principles of the multimodal interface in use, and its implications for the value of the field data. Subsequently we present one major result: the identification of two observable user interaction styles and their effect on user expectations from multimodal interface design. We call these styles maximal efficiency and maximal interactivity and determine characteristics for each style. Finally, we discuss implications for the design of speech-enabled multimodal interfaces in the automotive environment.
Pricing Equity Swaps in a Stochastic Interest Rate Economy

“A swap is a package of forward contracts, and the standard Òcost of carryÓ model for valuing forwards, like other-risk neutral valuation relationships, involves the riskless interest rate but not the expected price change on the underlying asset. Thus, in a basic equity swap, the current term structure of interest determines the swap rate, while the equity price process plays no role. It has been demonstrated that under non-stochastic interest rates, this result holds whether a swap has fixed or variable notional principal. Kijima and Muromachi introduce stochastic interest rates, and show that when notional principal is constant, the result is the same, but with variable notional principal, the stock price process does enter the swap valuation equation in the correlation between interest rate changes and stock returns. They derive valuation formulas for capped equity swaps in the same framework. ”
Short-Term Synaptic Plasticity Compensates for Variability in Number of Motor Neurons at a Neuromuscular Junction

We studied how similar postsynaptic responses are maintained in the face of interindividual variability in the number of presynaptic neurons. In the stomatogastric ganglion of the lobster, Homarus americanus, the pyloric (PY) neurons exist in variable numbers across animals. We show that each individual fiber of the stomach muscles innervated by PY neurons received synaptic input from all neurons present. We performed intracellular recordings of excitatory junction potentials (EJPs) in the muscle fibers to determine the consequences of differences in the number of motor neurons. Despite the variability in neuron number, the compound electrical response of muscle fibers to natural bursting input was similar across individuals. The similarity of total synaptic activation was not due to differences in the spiking activity of individual motor neurons across animals with different numbers of PY neurons. The amplitude of a unitary EJP in response to a single spike in a single motor neuron also did not depend on the number of PY neurons present. Consequently, the compound EJP in response to a single stimulus that activated all motor axons present was larger in individuals with more PY neurons. However, when axons were stimulated with trains of pulses mimicking bursting activity, EJPs facilitated more in individuals with fewer PY neurons. After a few stimuli, this resulted in depolarizations similar to the ones in individuals with more PY neurons. We interpret our findings as evidence that compensatory or homeostatic regulatory mechanisms can act on short-term synaptic dynamics instead of absolute synaptic strength.
Asymmetric Information, Delegation, and the Structure of Policy-Making

Congress uses varying degrees of specificity when passing legislation. Sometimes it writes very detailed, exacting laws; other times it leaves these details to implementing agencies. A natural positive question then arises: what factors are critical for understanding the degree of delegation used by Congress in a particular circumstance? This paper exploits the tradeoff between the distributive and informational effects of organizational design to examine congressional delegation. We argue that variations in the relative preferences of committee, floor (congressional median voter), and executive actors cause a rational floor voter to choose different forms of collective decision making. We find that homogeneity of committee-floor preferences leads to less delegation, while preference homogeneity between Congress and the executive leads to more delegation. We also argue that delegation emerges when actors are more risk averse or when the uncertainty characterizing the collective choice environment is large. We develop our logic using a game theoretic model of the policy-making process and draw out the empirical implications of our approach.
Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial.

BACKGROUND & AIMS Nonalcoholic steatohepatitis (NASH) is a liver disease that complicates insulin-resistant states. This trial tested the efficacy and safety of rosiglitazone, an insulin-sensitizing agent, in patients with NASH. METHODS Sixty-three patients with histologically proven NASH were randomly assigned to receive rosiglitazone (4 mg/day for the first month and 8 mg/day thereafter; n = 32) or placebo (n = 31) for 1 year. Liver biopsy was performed at the end of treatment. End points were improvement in the histologic score of steatosis, normalization of serum transaminase levels, and improvement in necroinflammation and fibrosis. RESULTS More patients treated with rosiglitazone than receiving placebo had improved steatosis (47% vs 16%; P = .014) and normalized transaminase levels (38% vs 7%; P = .005), although only half of patients responded. There was no improvement in other histologic lesions, including fibrosis, and a composite score of activity, the nonalcoholic fatty liver disease activity score. Improvement of steatosis correlated with reduction of transaminase levels (r = 0.36; P < .005), improvement in insulin sensitivity (r = 0.34; P = .008), and increase in adiponectin levels (r = -0.54; P < .01) but not with weight variations. Independent predictors of response were rosiglitazone treatment, the absence of diabetes, and massive steatosis. Weight gain was the main adverse effect (mean gain of 1.5 kg in the rosiglitazone group vs -1 kg in the placebo group; P < .01), and painful swollen legs was the main reason for dose reduction/discontinuation. Serum hemoglobin level was slightly but significantly reduced. There was no hepatic toxicity. CONCLUSIONS In patients with NASH, rosiglitazone improves steatosis and transaminase levels despite weight gain, an effect related to an improvement in insulin sensitivity. However, there is no improvement in other parameters of liver injury.
Mechanisms of Autonomous Pipe-Surface Inspection Robot with Magnetic Elements

In this paper, we propose a pipe inspection robot to move automatically along the outside of piping. In recent years, such pipe inspection robots and climbing robots have been the subject of important research activity worldwide [1]-[3]. Inspection of industrial pipe is a well-known and highly practical application of robotic technology. Robots especially designed to inspect the surface of pipe have recently been realized by some companies, and are in practical use as mechanical pipe inspection devices in various plants. Some of the robots have the capability of self-propelled inspection. These robots are equipped with ultrasonic diagnostic equipment that can measure the thickness of the pipe along its surface [4]. However, they are able to move by manual operation only. Such robots cannot be applied to pipes with flanges and valves, etc. We have designed a mechanism that enables robots to traverse flanges, rise along vertical flanges, and move along the underside of the piping [5]-[8]. The proposed robot is composed of three connected units.
New Developments in Mobility and Orientation Aids for the Blind

An overview of both early and recent developments in artificial aids for blind orientation and mobility is presented. Most aids developed previously fall into the category of "mobility aids" intended to sense obstacles in or near the traveler's immediate path. The more global problem of absolute orientation and navigation has not been well addressed by researchers in electronic aids, but this situation is now changing. A new system for aiding blind orientation, described here, is now advancing beyond the experimental stage.
Kalecki Versus Keynes on the Determinants of Investment

This paper explores the differences between the investment theories of Michal Kalecki and John Maynard Keynes. We argue that Kalecki's ideas (and empirical support for them) are necessary for Keynes's arguments regarding the determination of the level of effective demand. Kalecki's theory of the role of finance in investment also provides a fuller understanding of the importance of liquidity concerns for Keynesian theory and connects the theory of effective demand to the logic of capitalism.
Anthropogenic effects on the subtropical jet in the Southern Hemisphere: aerosols versus long-lived greenhouse gases

We use single-forcing historical simulations with a coupled atmosphere–ocean global climate model to compare the effects of anthropogenic aerosols (AAs) and increasing long-lived greenhouse gases (LLGHGs) on simulated winter circulation in the Southern Hemisphere (SH). Our primary focus is on the subtropical jet, which is an important source of baroclinic instability, especially in the Australasian region, where the speed of the jet is largest. For the period 1950 to 2005, our simulations suggest that AAs weaken the jet, whereas increasing LLGHGs strengthen the jet. The different responses are explained in terms of thermal wind balance: increasing LLGHGs preferentially warm the tropical mid-troposphere and upper troposphere, whereas AAs have a similar effect of opposite sign. In the mid-troposphere, the warming (cooling) effect of LLGHGs (AAs) is maximal between 20S and 30S; this coincides with the descending branch of the Hadley circulation, which may advect temperature changes from the tropical upper troposphere to the subtropics of the SH. It follows that LLGHGs (AAs) increase (decrease) the mid-tropospheric temperature gradient between low latitudes and the SH mid-latitudes. The strongest effects are seen at longitudes where the southward branches of the Hadley cell in the upper troposphere are strongest, notably at those that correspond to Asia and the western Pacific warm pool.
Restructuring supply chains through information channel innovation

This paper examines the optimisation of purchasing for maintenance, repair and operating supplies (MRO) through purchase process re‐engineering. In particular, the use and development of the Internet as a channel for procurement of MRO items was examined from a transaction cost perspective. The focus of this paper is on the impact of Web/Internet based electronic commerce on the structure of MRO supply chains. The paper provides a discussion of the theoretical basis for analysis of the impact of e‐commerce on supply chain structure, and presents existing literature in the area. The empirical research involved a series of semi‐structured interviews with UK, European and US based manufacturers, retailers, government bodies, and service organisations. Respondents ranged from experienced users of e‐procurement to organisations just starting out on their pilot investigations of the contribution of Internet trading to their purchasing efficiency. The impact on supply chain configuration of greater information transparency may be posited to be one which will lead to increased outsourcing, improved procurement processes and more strategic management of MRO purchases.
Identification of a Novel Helicase Activity Unwinding Branched DNAs from the Hyperthermophilic Archaeon, Pyrococcus furiosus*

To identify the branch migration activity in archaea, we fractionated Pyrococcus furiosus cell extracts by several chromatography and assayed for ATP-dependent resolution of synthetic Holliday junctions. The target activity was identified in the column fractions, and the optimal reaction conditions for the branch migration activity were determined using the partially purified fraction. We successfully cloned the corresponding gene by screening a heat-stable protein library made by P. furiosus genomic DNA. The gene, hjm (Holliday junction migration), encodes a protein composed of 720 amino acids. The Hjm protein is conserved in Archaea and belongs to the helicase superfamily 2. A homology search revealed that Hjm shares sequence similarity with the human PolΘ, HEL308, and Drosophila Mus308 proteins, which are involved in a DNA repair, whereas no similar sequences were found in bacteria and yeast. The Hjm helicase may play a central role in the repair systems of organisms living in extreme environments.
The unusual distribution of the neuronal/lymphoid cell surface CD200 (OX2) glycoprotein is conserved in humans

OX2 (CD200) is a type‐1 membrane glycoprotein that contains two immunoglobulin superfamily domains and which is expressed on a variety of lymphoid and non‐lymphoid cells in the rat. The recent characterization of a receptor for OX2 (OX2R) on myeloid cells, and the phenotype of an OX2‐deficient mouse, suggests that OX2 may regulate myeloid cell activity in anatomically diverse locations. Here we report the tissue distribution of the human homologue of the rat OX2 glycoprotein using a new monoclonal antibody (mAb), OX104, raised against recombinant human OX2. Human OX2 was expressed at the cell surface of thymocytes, B cells, T cells, neurons, kidney glomeruli, tonsil follicles, the syncytiotrophoblast and endothelial cells. This broad, but not ubiquitous, distribution pattern is very similar to that observed in rats, suggesting that OX2 may regulate myeloid cell activity in a variety of tissues in humans.
Using navigators to improve care of underserved patients

Logistic, cultural, educational, and other barriers can impede the delivery of high‐quality cancer care to underserved patients. Patient navigation services represent one innovation for addressing perceived barriers to care encountered by disadvantaged patients. In this report, the authors have 1) defined patient navigation, distinguishing it from other cancer support services; 2) described how programs are organized; and 3) discussed the need for research on program effectiveness.
Mobile marketing or mobile spam: who decides?

In recent years, the mobile phone has become a ubiquitous communication channel. The global adoption of the device and its technology by users has increased exponentially. The rise in the number of mobile phone subscribers globally is well documented and this can be attributed to the mobile phone's unique features, such as its portability, mobility and convenience. Marketers have recognised the emerging value of the mobile phone as a new channel of marketing and have an increasing interest in employing mobile marketing as one of their strategies. Whilst marketers should be lauded for embracing the new technology, there are concerns as to the manner and form which mobile marketing takes. To the consumer, unknown commercial text messages are seen as nothing more than unsolicited commercial messages (spam). Spam is the subject of regulation in a number of jurisdictions. The aim of this paper is to firstly examine what spam is and its implications. Secondly, the paper briefly considers some of the promulgated legislations. Finally, the paper evaluates the factors that should be considered to enhance a consumer's experience in mobile marketing.
The value relevance of earnings disaggregation provided in the Spanish profit and loss account

This study analyses the value relevance of the different components of the earnings figure that appear in the Spanish profit and loss account in order to determine the preferred level of disaggregation by investors. It is considered that the disaggregation may help to evaluate the earnings quality; that is, its predictive ability about future earnings. We use a valuation model based on Ohlson (1995), which models firm value as a function of book value of equity and earnings, adding the earnings components to determine whether they provide incremental price-relevant information beyond aggregate earnings. In addition, we allow the parameters to vary under some firm-specific circumstances. Our results support the usefulness of the earnings decomposition for valuation purposes, resting primarily on the disclosure of the corporation tax, particularly for either small companies, or with a high-risk profile or with low persistence of earnings. It seems that neither financial profit nor extraordinary earnings have additional information content over the bottom-line figure, which is consistent with the IASC's position on ordinary versus extraordinary items.
Crisis? What Crisis? Football in Germany

The purpose of this article is to describe the financial situation and the development of club finances of the German “Bundesliga”. Using data provided by the football association and data collected from a number of different sources we find that the majority of the teams are economically well established: Revenues have increased steadily, liabilities are under control, and player salaries have considerably declined. The ongoing debate about the liabilities of the German soccer teams is clearly misleading because two largemarket teams are principally responsible for the overall increase of the clubs' liabilities.
Regulation of inflorescence architecture by intertissue layer ligand–receptor communication between endodermis and phloem

Multicellular organisms achieve final body shape and size by coordinating cell proliferation, expansion, and differentiation. Loss of function in the Arabidopsis ERECTA (ER) receptor-kinase gene confers characteristic compact inflorescence architecture, but its underlying signaling pathways remain unknown. Here we report that the expression of ER in the phloem is sufficient to rescue compact er inflorescences. We further identified two EPIDERMAL PATTERNING FACTOR-LIKE (EPFL) secreted peptide genes, EPFL4 and EPFL6/CHALLAH (CHAL), as redundant, upstream components of ER-mediated inflorescence growth. The expression of EPFL4 or EPFL6 in the endodermis, a layer adjacent to phloem, is sufficient to rescue the er-like inflorescence of epfl4 epfl6 plants. EPFL4 and EPFL6 physically associate with ER in planta. Finally, transcriptome analysis of er and epfl4 epfl6 revealed a potential downstream component as well as a role for plant hormones in EPFL4/6- and ER-mediated inflorescence growth. Our results suggest that intercell layer communication between the endodermis and phloem mediated by peptide ligands and a receptor kinase coordinates proper inflorescence architecture in Arabidopsis.
Capital Stocks and Productivity in Industrial Nations

This article presents estimates of the contribution of physical capital to explaining labour productivity differences between Britain and four of her major competitors, the United States, Germany, France and Japan. The paper uses a standardised method to estimate capital stocks in the five countries. It presents arguments why this may be preferable to comparing official capital stock figures since the latter are sensitive to differences in measurement techniques used by the statistical offices. In the aggregate economy differences in physical capital are important in explaining labour productivity levels in Britain relative to the United States, Germany and France but cannot explain Britain's labour productivity advantage over Japan. In manufacturing Britain's lower capital per unit of labour also helps explain her lower labour productivity levels relative to all four countries but the contribution of capital is generally lower in manufacturing than for the aggregate economy. For both the aggregate economy and manufacturing differences in capital growth rates help explain Britain's productivity growth performance in the past three decades relative to the United States and Japan but have little explanatory power relative to Germany and France.
On the Reliability of Individual Brain Activity Networks

There is intense interest in fMRI research on whole-brain functional connectivity, and however, two fundamental issues are still unresolved: the impact of spatiotemporal data resolution (spatial parcellation and temporal sampling) and the impact of the network construction method on the reliability of functional brain networks. In particular, the impact of spatiotemporal data resolution on the resulting connectivity findings has not been sufficiently investigated. In fact, a number of studies have already observed that functional networks often give different conclusions across different parcellation scales. If the interpretations from functional networks are inconsistent across spatiotemporal scales, then the whole validity of the functional network paradigm is called into question. This paper investigates the consistency of resting state network structure when using different temporal sampling or spatial parcellation, or different methods for constructing the networks. To pursue this, we develop a novel network comparison framework based on persistent homology from a topological data analysis. We use the new network comparison tools to characterize the spatial and temporal scales under which consistent functional networks can be constructed. The methods are illustrated on Human Connectome Project data, showing that the DISCOH2 network construction method outperforms other approaches at most data spatiotemporal resolutions.
Modulation of Cellular and Viral Gene Expression by the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus

ABSTRACT Kaposi's sarcoma-associated herpesvirus (KSHV), also called human herpesvirus 8 (HHV-8), is the likely etiological agent of Kaposi's sarcoma and primary effusion lymphoma. Common to these malignancies is that tumor cells are latently infected with KSHV. Viral gene expression is limited to a few genes, one of which is the latency-associated nuclear antigen (LANA), the product of ORF73. Examination of the primary sequence of LANA reveals some structural features reminiscent of transcription factors, leading us to hypothesize that LANA may regulate viral and cellular transcription during latency. In reporter gene-based transient transfection assays, we found that LANA can have either positive or negative effects on gene expression. While expression of a reporter gene from several synthetic promoters was increased in the presence of LANA, expression from the human immunodeficiency virus (HIV) long terminal repeat (LTR)—and from NF-κB-dependent reporter genes—was reduced by LANA expression. In addition, the promoter of KSHV ORF73 itself is activated up to 5.5-fold by LANA. This autoregulation may be important in tumorigenesis, because two other genes (v-cyclin and v-FLIP) with likely roles in cell growth and survival are also controlled by this element. To identify cellular genes influenced by LANA, we employed cDNA array-based expression profiling. Six known genes (and nine expressed sequence tags) were found to be upregulated in LANA-expressing cell lines. One of these, Staf-50, is known to inhibit expression from the HIV LTR; most of the other known genes are interferon inducible, although the interferon genes themselves were not induced by LANA. These data demonstrate that LANA expression has effects on cellular and viral gene expression. We suggest that, whether direct or indirect in origin, these effects may play important roles in the pathobiology of KSHV infection.