Miracle-dz/UniFAR-FTUs huggingface dataset:
A randomized cross-over study on the blood pressure lowering effect of the combined passive head-up and -down movement with Device-Guided slow breathing

Abstract Purpose: Baroreflex emerges as a therapeutic target of hypertension. We investigated blood pressure (BP) lowering effect of the combined passive head-up and -down movement with device-guided slow breathing in untreated mild hypertension or high-normal BP. Methods: In a randomized, cross-over trial, untreated subjects with an ambulatory systolic/diastolic BP of 125–140/80–90 mmHg and a clinic BP of 130–150/80–90 mmHg were randomized to intervention treatment with head movement and slow breathing or sham control, and then crossed over. Both treatments consisted of 1-week preparation, 2-week treatment, and 1-week recovery. During the 2-week treatment, subjects were treated for a session of 20 min/day. BP, pulse rate and respiration were measured before and after each treatment session. Ambulatory BP monitoring was performed at baseline and the end of the 2-week treatments’ period, and home BP monitoring in the morning and evening for the whole 8-week follow-up period. Results: 14 subjects completed the study. The intervention treatment, compared to control, reduced respiration rate by −2.1 breaths/min (95% CI −2.9 to −1.2, p = .0001), but not clinic BP and pulse rate (p ≥ .67). The intervention treatment, compared to control, significantly reduced nighttime systolic/diastolic blood pressure by −5.63/−3.82 mm Hg (p ≤ .01) but not 24-h or daytime ambulatory blood pressure (p ≥ .69). Home BP decreased with the intervention treatment, but the between-treatment difference was not statistically significant (p ≥ .27). Conclusions: The combined head movement with slow breathing did not influence 24-h BP, but reduced nighttime BP in untreated mild hypertension or high-normal BP.
Best Prices

We explore the role of strategic price-discrimination by retailers for price determination and inflation dynamics. We model two types of customers, "loyals" who buy only one brand and do not strategically time purchases, and "shoppers" who seek out low-priced products both across brands and across time. Shoppers always pay the lowest price available, the "best price". Retailers in this setting optimally choose long periods of constant regular prices punctuated by frequent temporary sales. Supermarket scanner data confirm the model's predictions: the average price paid is closely approximated by a weighted average of the fixed weight average list price and the "best price". In contrast to standard menu cost models, our model implies that sales are an essential part of the price plan and the number and frequency of sales may be an important mechanism for adjustment to shocks. We conclude that our "best price" construct provides a tractable input for constructing price series.
A Lumped Parameter Method to Calculate the Effect of Internal Carotid Artery Occlusion on Anterior Cerebral Artery Pressure Waveform

Background and Objective Numerical modeling of biological structures would be very helpful tool to analyze hundreds of human body phenomena and also diseases diagnosis. One physiologic phenomenon is blood circulatory system and heart hemodynamic performance that can be simulated by utilizing lumped method. In this study, we can predict hemodynamic behavior of one artery of circulatory system (anterior cerebral artery) when disease such as internal carotid artery occlusion is occurred. Method Pressure-flow simulation is one the leading common approaches for modeling of circulatory system behavior and forecasts of hemodynamic in numerous physiological conditions. In this paper, by using lumped model (electrical analogy), CV system is simulated in MATLAB software (SIMULINK environment). Results The performance of healthy blood circulation and heart is modeled and the obtained results used for further analyses. The stenosis of internal carotid artery at different rates was, then, induced in the circuit and the effects are studied. In stenosis cases, the effects of internal carotid artery occlusion on left anterior cerebral artery pressure waveform are investigated. Conclusion The findings of this study may have implications not only for understanding the behavior of human biological system at healthy condition but also for diagnosis of diseases in circulatory and cardiovascular system of human body.
Illegal Trade of Wild-Captured Lemur catta within Madagascar

Lemur catta is the most reported illegal captive lemur. We document 286 L. catta that were held in illegal captive conditions in Madagascar. Coastal tourist destinations are “hot spots” for sightings. Many of the L. catta reported were in businesses (49%) and were perceived to be held captive for the purpose of generating income (41%). Infant/juvenile L. catta were overwhelmingly observed annually in December (41%) and may suffer high mortality rates given that they are not weaned during this month of the year. Population growth modeling suggests that known capture rates may be sustainable in all but small populations of 500 individuals and when infants/juveniles are targeted. However, of the seven remaining populations of L. catta with more than 100 individuals, only one is known to contain more than 500 animals, and we present evidence here that infants/juveniles are targeted. Moreover L. catta face significant other threats including habitat loss, bushmeat hunting, and climate change. Several actions could reduce the illegal capture and ownership of L. catta in Madagascar such as tourist behavior change initiatives, enforcement of laws, and alternative livelihoods for local people. These interventions are urgently needed and could be adapted to protect other exploited wildlife in the future.
Interactive effects of dopamine transporter genotype and aging on resting-state functional networks

Aging and dopamine modulation have both been independently shown to influence the functional connectivity of brain networks during rest. Dopamine modulation is known to decline during the course of aging. Previous evidence also shows that the dopamine transporter gene (DAT1) influences the re-uptake of dopamine and the anyA9 genotype of this gene is associated with higher striatal dopamine signaling. Expanding these two lines of prior research, we investigated potential interactive effects between aging and individual variations in the DAT1 gene on the modular organization of brain acvitiy during rest. The graph-theoretic metrics of modularity, betweenness centrality and participation coefficient were assessed in 41 younger (age 20–30 years) and 37 older (age 60–75 years) adults. Age differences were only observed in the participation coefficient in carriers of the anyA9 genotype of the DAT1 gene and this effect was most prominently observed in the default mode network. Furthermore, we found that individual differences in the values of the participation coefficient correlated with individual differences in fluid intelligence and a measure of executive control in the anyA9 carriers. The correlation between participation coefficient and fluid intelligence was mainly shared with age-related differences, whereas the correlation with executive control was independent of age. These findings suggest that DAT1 genotype moderates age differences in the functional integration of brain networks as well as the relation between network characteristics and cognitive abilities.
Ditch the Smileys: Customizing a Stopword List for Email-based Data

The study uses grounded theory approach to develop different categories of stopwords leading to the creation of a stopword list for email-based data. The finding of the study will contribute in better understanding of email as data and developing better algorithms which could automatically remove specific category of stopwords. Cette etude se base sur la theorie a base empirique pour developper differentes categories de mots vides qui seront utilises pour creer une liste aux fins d'analyse des donnees issues de courriels. Les resultats permettront une meilleure comprehension des courriels comme source de donnees et la creation de meilleurs algorithmes de suppression automatique de categories precises de mots vides.
Dynamics of intersecting brane systems ? Classification and their applications

We present dynamical intersecting brane solutions in higher-dimensional gravitational theory coupled to dilaton and several forms. Assuming the forms of metric, form fields, and dilaton field, we give a complete classification of dynamical intersecting brane solutions with/without M-waves and Kaluza-Klein monopoles in eleven-dimensional supergravity. We apply these solutions to cosmology and black holes. It is shown that these give FRW cosmological solutions and in some cases Lorentz invariance is broken in our world. If we regard the bulk space as our universe, we may interpret them as black holes in the expanding universe. We also discuss lower-dimensional effective theories and point out naive effective theories may give us some solutions which are inconsistent with the higher-dimensional Einstein equations.
The original boneheads: histologic analysis of the pachyostotic skull roof in Permian burnetiamorphs (Therapsida: Biarmosuchia)

Thickened, pachyostotic skulls are best known in pachycephalosaur dinosaurs, but evolved convergently in Permian burnetiamorphs as well as in some other stem‐mammal groups and Triassic archosauromorphs. Until now, only pachycephalosaur domes have been histologically sampled to reveal patterns of bone tissue microstructure and growth. Using computed tomography and osteohistology, we serially thin‐sectioned one of the smallest burnetiamorph skull caps ever recovered (estimated skull length = 10 cm), as well as an individual nearly twice as large, and here report the first cranial histological data from this clade. We recognize four highly vascularized histological zones visible in coronal thin‐sections, only one of which shares morphological similarities with the tripartite zonation previously reported in pachycephalosaur domes. Zone A forms the endocranial region of the skull cap and records disorganized primary osteons in a fibrolamellar complex. Zone B preserves a border of compact, avascular layers of parallel‐fibered bone surrounding an interior of partially remodeled vascular canals. Interestingly, the outline of Zone B resembles the shape of an incipient skull roof. Zone C forms the thickest portion of the skull cap and is composed of fast‐growing woven bone with minimal osteonal development. The superficial Zone D has a matrix of predominantly woven bone with narrower primary vascular canals than in deeper regions of the skull caps. Unlike in pachycephalosaurs, where primary vascular porosity is thought to decrease through ontogeny, both burnetiamorph skull caps preserve a thick Zone C of highly vascularized tissue. Additionally, the remnants of sutures are visible as radial struts that taper superficially, leaving no trace on the surface of the skull. Even in the smallest individual, the sutures are closed ectocranially, which is unusual, given that some large, presumably adult pachycephalosaur domes preserve open sutural gaps. Although pachycephalosaur and burnetiamorph skull domes are superficially similar, histological analysis reveals differences in their vascularity and construction that imply multiple evolutionary pathways to form an elaborate pachyostotic dome.
LETTER TO THE EDITOR: Transport and elementary excitations of a Luttinger liquid

The low-temperature AC conductance of a one-dimensional electron system with a strong interaction of finite range is calculated by using linear response theory. The conductance factorizes into parts which depend on the internal properties of the system, and the external probe. For short-range interaction, the result resembles that for non-interacting electrons, but with the zero-frequency limit and the Fermi velocity renormalized by the interaction strength. For strong and long-range interaction, the conductance shows a peak that is related to charge-wave excitations. In this limit, the AC conductance can be simulated by a quantum capacitance and a quantum inductance.
New iterative algorithm for the computation of the rank-deficient Capon filter in spectral estimation

In nonparametric complex spectral estimation, higher resolution is achieved when the covariance matrix is allowed to be rank-deficient. Several approaches are applied to remedy matrix singularity, such as diagonal loading, rank reduction and additional constraints. Conventional solution of the optimal Capon filter is derived from the gradient functions of the constraint minimization problem, and calculated via the input covariance matrix inversion. In this paper, the gradient functions are reformulated as a single one with the same solution, which is solved by an adaptive-step algorithm based on conjugate gradient method. The optimal Capon filter is iteratively calculated without any matrix inversion. The proposed algorithm is also directly applied to the computation of the optimal Capon filter with rank-deficient input covariance matrix. In simulations, performances of the proposed algorithm are compared with the existing methods. Higher convergence speed is achieved. The iteration number is selected to offset the frequency resolution and the signal mismatch problem.
Effects of Song Experience and Song Quality on Immediate Early Gene Expression in Female Canaries (Serinus canaria)

Female songbirds are thought to make mate choices based on aspects of male song quality. Male canaries (Serinus canaria) produce songs with “special” syllables that have been shown to be highly salient to female listeners – eliciting high rates of sexual displays and enhanced immediate early gene (IEG) expression. Immunohistochemistry for the IEG ZENK was used to examine the effects of experience with these syllables on activity in the caudal mesopallium (CMM) and nidocaudal mesopallium (NCM), two auditory areas important in processing conspecific song. Photostimulated female canaries were housed in sound attenuated chambers and played pseudosongs containing either three special syllables or three non‐special syllables, an intro, and an outro sequence. Females that heard special syllable pseudosongs exhibited higher ZENK expression in CMM. To assess the effects of experience, photostimulated females were pair housed and exposed to playback of song with or without special syllables for 14 days. After transfer to individual housing, birds were played one of the aforementioned stimuli or silence. ZENK expression in CMM and NCM was equivalent for song with and without special syllables, but significantly lower for silence. Females who experienced song with special syllables had lower plasma estradiol concentrations after final song playback. This study indicates that CMM exhibits an IEG response bias to special syllables in limited acoustic contexts, but not in full song, which may contain additional biologically relevant information. Furthermore, estradiol concentrations may mediate changes in song responses, serving as a mechanism for modulating mate choice in differing song environments.
2-O-digalloyl-1,3,4,6-tetra-O-galloyl-β-D-glucose isolated from Galla Rhois suppresses osteoclast differentiation and function by inhibiting NF-κB signaling

Natural compounds isolated from medicinal herbs and plants have immense significance in maintaining bone health. Hydrolysable tannins have been shown to possess a variety of medicinal properties including antiviral, anticancer, and anti-osteoclastogenic activities. As a part of a study on the discovery of alternative agent against skeletal diseases, we isolated a hydrolysable tannin, 2-O-digalloyl-1,3,4,6-tetra-O-galloyl- β-D-glucose (DTOGG), from Galla Rhois and examined the effect on osteoclast formation and function. We found that DTOGG significantly inhibited receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation by downregulating the expression of the key regulator in osteoclastogenesis as well as osteoclast-related genes. Analysis of RANKL/RANK signaling revealed that DTOGG impaired activation of IκBα and p65 in the nuclear factor kappa-light-chain- enhancer of activated B cells (NF-κB) signaling pathway. Furthermore, DTOGG reduced bone resorbing activity of osteoclasts, compared to the vehicle-treated control. These results suggest that DTOGG could be a useful natural compound to manage osteoclast-mediated skeletal diseases.
Neurobiological features and response to eye movement desensitization and reprocessing treatment of posttraumatic stress disorder in patients with breast cancer

ABSTRACT Background: Breast cancer (BC) is one of the most common invasive types of cancer among women, with important consequences on both physical and psychological functioning. Patients with BC have a great risk of developing posttraumatic stress disorder (PTSD), but few studies have evaluated the efficacy of psychological interventions to treat it. Furthermore, no neuroimaging studies have evaluated the neurobiological effects of psychotherapeutic treatment for BC-related PTSD. Objective: The study aimed to evaluate the efficacy of Eye Movement Desensitization and Reprocessing therapy (EMDR) as compared to Treatment as Usual (TAU) in BC patients with PTSD, identifying by electroencephalography (EEG) the neurophysiological changes underlying treatments effect and their correlation with clinical symptoms. Method: Thirty patients with BC and PTSD diagnosis were included, receiving either EMDR (n = 15) or TAU (n = 15). Patients were assessed before and after treatments with clinical questionnaires and EEG. The proportion of patients who no longer meet criteria for PTSD after the intervention and changes in clinical scores, both between and within groups, were evaluated. Two-sample permutation t-tests among EEG channels were performed to investigate differences in power spectral density between groups. Pearson correlation analysis was carried out between power bands and clinical scores. Results: At post-treatment, all patients treated with EMDR no longer met criteria for PTSD, while all patients treated with TAU maintained the diagnosis. A significant decrease in depressive symptoms was found only in the EMDR group, while anxiety remained stable in all patients. EEG results corroborated these findings, showing significant differences in delta and theta bands in left angular and right fusiform gyri only in the EMDR group. Conclusions: It is essential to detect PTSD symptoms in patients with BC, in order to offer proper interventions. The efficacy of EMDR therapy in reducing cancer-related PTSD is supported by both clinical and neurobiological findings. HIGHLIGHTS • In accordance with DSM-5 criteria, the prevalence of cancer-related PTSD diagnosis in our sample of women with breast cancer was 8.1%. • EMDR was significantly superior to TAU in reducing PTSD and associated depressive symptoms. • Clinical improvement following EMDR was associated with an increase in neuronal synchronization in left angular and in right fusiform gyri.
Clinicians' Perspectives on Barriers and Enablers of Optimal Prescribing in Patients with Dementia and Coexisting Conditions

Purpose: Patients with dementia experience high rates of polypharmacy, potentially inappropriate medication use, and adverse drug events. There is little guidance for clinicians on how to optimize prescribing for this population. Our objective was to investigate clinician-perceived barriers to and facilitators of optimizing prescribing for people with dementia. Methods: Qualitative study involving semistructured interviews of primary care and specialist clinicians in urban, suburban, and rural settings. Transcripts were analyzed using qualitative content analysis. Results: Interviews were conducted with 12 primary care and 9 specialist clinicians, with a mean (SD) age of 47 (9) and mean (SD) of 14 (10) years in practice. Clinicians cited decisions regarding the following drug classes as particularly challenging: oral anticoagulants, antidiabetic agents, statins, bladder antimuscarinics, and antipsychotics. Perceived enablers of optimizing prescribing included access to interdisciplinary services and guidelines for nondementia illnesses (eg, diabetes) addressing the care of people with dementia. Barriers included the lack of data on efficacy and safety of most medications in people with dementia, difficulty assessing medication effects in an individual patient, and the perception that stopping medications is seen as “giving up. ” Clinicians used a variety of strategies to discuss risks and benefits of medications with patients and caregivers. Conclusions: Clinicians identified numerous barriers to and some facilitators of optimizing prescribing in people with dementia. More data are needed on the benefits and harms of stopping medications in this population. Research should also test different approaches for supporting informed decision making about medications by people with dementia and caregivers.
How was your day? Convergence of aggregated momentary and retrospective end-of-day affect ratings across the adult life span.

Daily diary studies and experience sampling studies examine day-to-day variations in affect using different rating types: The former typically collect retrospective affect reports at the end of the day, whereas the latter collects multiple momentary assessments across the day. The present study examined the convergence of (aggregated) momentary assessments collected repeatedly within a day and retrospective assessments collected at the end of the day. Building on prior research on the memory-experience gap and the peak-and-end rule we predicted that participants would report more intense retrospective affect than aggregated momentary affect, and that retrospective affect would be biased toward the peak and the most recent affect of the day. Based on socioemotional selectivity theory and the strength and vulnerability integration model, age differences in these convergence indicators were expected. Findings from 2 age-heterogeneous ecological momentary assessment/daily diary hybrid studies (N = 242, 25-65 years; and N = 175, 20-79 years) revealed (a) a memory-experience gap for negative affect (more intense retrospective ratings than aggregated momentary ratings) that is attenuated with advancing age; (b) only a small memory-experience gap for positive affect for very old adults (66-79 years), but not younger adults; (c) relatively high convergence of aggregated momentary ratings and retrospective ratings despite (d) small biases of retrospective negative affect ratings toward peak and most recent negative affect. Findings suggest that both rating types can discriminate "good days" from "bad days" and provide overlapping but not necessarily exchangeable information. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Increased Hypermutation at G and C Nucleotides in Immunoglobulin Variable Genes from Mice Deficient in the MSH2 Mismatch Repair Protein

Rearranged immunoglobulin variable genes are extensively mutated after stimulation of B lymphocytes by antigen. Mutations are likely generated by an error-prone DNA polymerase, and the mismatch repair pathway may process the mispairs. To examine the role of the MSH2 mismatch repair protein in hypermutation, Msh2 −/− mice were immunized with oxazolone, and B cells were analyzed for mutation in their VκOx1 light chain genes. The frequency of mutation in the repair-deficient mice was similar to that in Msh2 +/+ mice, showing that MSH2-dependent mismatch repair does not cause hypermutation. However, there was a striking bias for mutations to occur at germline G and C nucleotides. The results suggest that the hypermutation pathway frequently mutates G·C pairs, and a MSH2-dependent pathway preferentially corrects mismatches at G and C.