Miracle-dz/UniFAR-FTUs huggingface dataset:
A direct simulation demonstrating the role of spacial heterogeneity in determining anomalous diffusive transport

Typically the spreading length‐scale in a diffusion process increases in time as ℓ∼tn,n=12 . In the presence of spatial heterogeneities, however, so‐called anomalous diffusion can occur, here the time exponent n≠12 . The objective of this paper is to present a numerical simulation that directly demonstrates the link between spacial heterogeneity and anomalous diffusion. The simulation is of the infiltration of a fluid into a horizontal unit area Hele‐Shaw cell in which the permeability at specified locations, laid out as a Sierpinski fractal carpet pattern, can differ from the nominal value K = 1. When there is no permeability contrast, the fluid infiltration has a diffusion‐like behavior, i.e., the filled plan‐form area increases in time as F=Atn,n=12 . When there is a permeability contrast, however, although the evolution of infiltration still follows a power law, anomalous behavior is observed; subdiffusive ( n<12 ) when K < 1 and superdiffusive ( n>12 ) when K > 1. These anomalous behaviors persist, even when the permeability contrast is only imposed over the largest sized fractal pattern element. But, if the pattern over which the permeability contrast is imposed has a subdomain length scale (obtained by filling in the largest sized element in the Sierpinski carpet with the smaller sized elements), normal diffusion n=12 behavior is recovered. In the special case that the imposed permeability in the pattern elements is K≪1 , an approximate model, directly relating the coefficient and exponent in the infiltration power law to the porosity and fractal dimension of the carpet pattern, is derived and validated.
Nonlinear Imaging and Spectroscopy of Chiral Metamaterials

A chiral metamaterial produces both distinguishable linear and non-linear resonant features when probed with left and right circularly polarized light. The material demonstrates a linear transmission contrast of 0.5 between left and right circular polarizations and a 20× contrast between second-harmonic responses from the two incident polarizations. Non-linear and linear response images probed with circularly polarized light show strongly defined contrast.
BamHI-A rightward frame 1, an Epstein–Barr virus-encoded oncogene and immune modulator

Epstein–Barr virus (EBV) causes several benign and malignant disorders of lymphoid and epithelial origin. EBV‐related tumors display distinct patterns of viral latent gene expression, of which the BamHI‐A rightward frame 1 (BARF1) is selectively expressed in carcinomas, regulated by cellular differentiation factors including ΔNp63α. BARF1 functions as a viral oncogene, immortalizing and transforming epithelial cells of different origin by acting as a mitogenic growth factor, inducing cyclin‐D expression, and up‐regulating antiapoptotic Bcl‐2, stimulating host cell growth and survival. In addition, secreted hexameric BARF1 has immune evasive properties, functionally corrupting macrophage colony stimulating factor, as supported by recent functional and structural data. Therefore, BARF1, an intracellular and secreted protein, not only has multiple pathogenic functions but also can function as a target for immune responses. Deciphering the role of BARF1 in EBV biology will contribute to novel diagnostic and treatment options for EBV‐driven carcinomas. Herein, we discuss recent insights on the regulation of BARF1 expression and aspects of structure‐function relating to its oncogenic and immune suppressive properties. © 2013 The Authors. Reviews in Medical Virology published by John Wiley & Sons, Ltd.
Brain, music, and non-Poisson renewal processes.

In this paper we show that both music composition and brain function, as revealed by the electroencephalogram (EEG) analysis, are renewal non-Poisson processes living in the nonergodic dominion. To reach this important conclusion we process the data with the minimum spanning tree method, so as to detect significant events, thereby building a sequence of times, which is the time series to analyze. Then we show that in both cases, EEG and music composition, these significant events are the signature of a non-Poisson renewal process. This conclusion is reached using a technique of statistical analysis recently developed by our group, the aging experiment (AE). First, we find that in both cases the distances between two consecutive events are described by nonexponential histograms, thereby proving the non-Poisson nature of these processes. The corresponding survival probabilities Psi(t) are well fitted by stretched exponentials [Psi(t) proportional, variant exp (-(gammat){alpha}) , with 0.5<alpha<1 . ] The second step rests on the adoption of AE, which shows that these are renewal processes. We show that the stretched exponential, due to its renewal character, is the emerging tip of an iceberg, whose underwater part has slow tails with an inverse power law structure with power index mu=1+alpha. Adopting the AE procedure we find that both EEG and music composition yield mu<2. On the basis of the recently discovered complexity matching effect, according to which a complex system S with mu{S}<2 responds only to a complex driving signal P with mu{P}< or =mu{S}, we conclude that the results of our analysis may explain the influence of music on the human brain.
Efficient Compute-and-Forward Network Codes Search for Two-Way Relay Channel

We consider the two-way relay channel (TWRC) with compute-and-forward network coding strategy. First a new lemma is proposed as network codes search criteria for TWRC. Then, instead of exhaustive search, we present an efficient network codes search algorithm based on modified Fincke-Pohst method. Numerical results demonstrate the effectiveness and complexity reduction of our proposed lemma and algorithm.
Calibration of Rogowski Coils With an Integrator at High Currents

This paper describes the calibration of Rogowski coils with an integrator for current measurement in the current range of up to 30 kA, at mains frequency. A current loop of ten turns with a current of 3 kA was used for calibration. The magnetic field generated in this way differs from the field of one turn placed at the center and passed with a current of 30 kA. The influence of the unevenness of winding and the cross section of the Rogowski coil may cause a calibration error when using a current loop. The difference in the results between using a current loop and one turn, and the measurement uncertainties are given here. Calculations of the mutual inductances of typical Rogowski coils and their uncertainties are presented in the Appendix.
Atrial fibrillation and stroke : concepts and controversies.

In 1985, patients with nonvalvular atrial fibrillation (AF) first entered randomized clinical trials that tested antithrombotic therapies for stroke prevention.1 2 3 Since then, >12 000 AF patients have been included in 25 trials that involved >40 randomized treatment comparisons (Table 1⇓). During this interval, we reviewed the pathogenesis and prevention of stroke in AF patients in 2 previous editorials in Stroke . 4 5 Here, we offer commentary on selected concepts and controversies. View this table: Table 1. Randomized Trials of Antithrombotic Therapy in Atrial Fibrillation The prevalence of AF increases with age, affecting ≈5% of people at age 70 years. Although AF-associated stroke can occur at any age, it is predominantly a problem of the elderly. The median age of AF patients with stroke in population-based studies is ≈75 years; more than half are women. In people over age 75, AF is the most important single cause of ischemic stroke. This epidemiology is relevant when considering stroke prevention, because the risks of and ability to sustain preventive therapies are special problems for the very elderly. The left atrial appendage is a unique substrate for stroke. It is an elongated cul-de-sac lined with endothelium, a remnant of the embryonic atrium, trabeculated by pectinate muscles (Figure 1⇓). The contractility of the appendage is reduced in AF, but the degree varies widely and is an important determinant of stasis and thrombus formation. In AF patients, atrial thrombi almost always originate in the appendage, rather than in the smooth-walled atrium proper, and are not reliably detected with transthoracic echocardiography. Transesophageal echocardiography is much more sensitive for the detection of appendage thrombi in AF patients, but the complex structure is usually multilobed, projecting in unpredictable planes. This, coupled with the minute size of clinically important thrombi (2 to 3 mm), makes the exclusion of small …
Domestic Space: Virtually Underestimated?

This paper discusses the concept of domestic space as a transformative communications environment; a space in which relationships among individuals, families and ultimately the community are sustained, and in some cases transformed. Drawing on a research project currently being conducted in Western Australia, this paper explores communication within domestic space from an historical (Fischer, 1992; Moyal, 1992) and empirical perspective (Frissen, 1995; Holloway & Green, 2004), and contends that the seemingly mundane quality of the domestic sphere has resulted in it being underestimated as an avenue for research. Moreover, a research focus on young people’s uptake of information and communications technologies (ICTs), particularly as artefacts of empowerment and independence (Boyd, 2007; Ling, 2007), has tended to overlook the degree to which ICTs have become embedded in domestic spaces through women’s appropriation of multiple communication technologies in their work as kin-keepers (Helgeson, 1994, p. 412) and ‘domestic relations specialists’ (Wellman & Wortley, 1990, p. 582). This paper aims to address this gap in the literature by examining women’s communicative agency in the domestic sphere, and the potential this have to transform relationships among families, friends, and ultimately communities.
A scenario-matching approach to the description and model checking of real-time properties

A major obstacle in the technology transfer agenda of behavioral analysis and design methods is the need for logics or automata to express properties for control-intensive systems. Interaction-modeling notations may offer a replacement or a complement, with a practitioner-appealing and lightweight flavor, due partly to the sub specification of intended behavior by means of scenarios. We propose a novel approach consisting of engineering a new formal notation of this sort based on a simple compact declarative semantics: VTS (visual timed event scenarios). Scenarios represent event patterns, graphically depicting conditions over traces. They predicate general system events and provide features to describe complex properties not expressible with MSC-like notations. The underlying formalism supports partial orders and real-time constraints. The problem of checking whether a timed-automaton model has a matching trace is proven decidable. On top of this kernel, we introduce a notation to state properties over all system traces: conditional scenarios, allowing engineers to describe uniquely rich connections between antecedent and consequent portions of the scenario. An undecidability result is presented for the general case of the model-checking problem over dense-time domains, to later identify a decidable-yet practically relevant-subclass, where verification is solvable by generating antiscenarios expressed in the VTS-kernel notation.
Vascular air embolism

Vascular air embolism is a rare but potentially fatal event. It may occur in a variety of procedures and surgeries but is most often associated as an iatrogenic complication of central line catheter insertion. This article reviews the incidence, pathophysiology, diagnosis, treatment, and prevention of this phenomenon.
Assessing the combined effects of climatic factors on spring wheat phenophase and grain yield in Inner Mongolia, China

Understanding the regional relationships between climate change and crop production will benefit strategic decisions for future agricultural adaptation in China. In this study, the combined effects of climatic factors on spring wheat phenophase and grain yield over the past three decades in Inner Mongolia, China, were explored based on the daily climate variables from 1981–2014 and detailed observed data of spring wheat from 1981–2014. Inner Mongolia was divided into three different climate type regions, the eastern, central and western regions. The data were gathered from 10 representative agricultural meteorological experimental stations in Inner Mongolia and analysed with the Agricultural Production Systems Simulator (APSIM) model. First, the performance of the APSIM model in the spring wheat planting areas of Inner Mongolia was tested. Then, the key climatic factors limiting the phenophases and yield of spring wheat were identified. Finally, the responses of spring wheat phenophases and yield to climate change were further explored regionally. Our results revealed a general yield reduction of spring wheat in response to the pronounced climate warming from 1981 to 2014, with an average of 3564 kg·ha-1. The regional differences in yields were significant. The maximum potential yield of spring wheat was found in the western region. However, the minimum potential yield was found in the middle region. The air temperature and soil surface temperature were the optimum climatic factors that affected the key phenophases of spring wheat in Inner Mongolia. The influence of the average maximum temperature on the key phenophases of spring wheat was greater than the average minimum temperature, followed by the relative humidity and solar radiation. The most insensitive climatic factors were precipitation, wind speed and reference crop evapotranspiration. As for the yield of spring wheat, temperature, solar radiation and air relative humidity were major meteorological factors that affected in the eastern and western Inner Mongolia. Furthermore, the effect of the average minimum temperature on yield was greater than that of the average maximum temperature. The increase of temperature in the western and middle regions would reduce the spring wheat yield, while in the eastern region due to the rising temperature, the spring wheat yield increased. The increase of solar radiation in the eastern and central regions would increase the yield of spring wheat. The increased air relative humidity would make the western spring wheat yield increased and the eastern spring wheat yield decreased. Finally, the models describing combined effects of these dominant climatic factors on the maturity and yield in different regions of Inner Mongolia were used to establish geographical differences. Our findings have important implications for improving climate change impact studies and for local agricultural production to cope with ongoing climate change.
Characteristics of luminous structures in the stratosphere above thunderstorms as imaged by low-light video

An experiment was conducted in which an image-intensified, low-light video camera systematically monitored the stratosphere above distant (100–800 km) mesoscale convective systems over the high plains of the central U.S. for 21 nights between 6 July and 27 August 1993. Complex, luminous structures were observed above large thunderstorm clusters on eleven nights, with one storm system (7 July 1993) yielding 248 events in 410 minutes. Their duration ranged from 33 to 283 ms, with an average of 98 ms. The luminous structures, generally not visible to the naked, dark-adapted eye, exhibited on video a wide variety of brightness levels and shapes including streaks, aurora-like curtains, smudges, fountains and jets. The structures were often more than 10 km wide and their upper portions extended to above 50 km msl.
Identification of a Novel Glutathione Conjugate of Flutamide in Incubations with Human Liver Microsomes

Flutamide, a nonsteroidal antiandrogen drug widely used in the treatment of prostate cancer, has been associated with rare incidences of hepatotoxicity in patients. It is believed that bioactivation of flutamide and subsequent covalent binding to cellular proteins is responsible for its toxicity. Current in vitro studies were undertaken to probe the cytochrome P450 (P450)-mediated bioactivation of flutamide and identify the possible reactive species using reduced glutathione (GSH) as a trapping agent. NADPH- and GSH-supplemented human liver microsomal incubations of flutamide gave rise to a novel GSH conjugate where GSH moiety was conjugated to the flutamide molecule via the amide nitrogen, resulting in a sulfenamide. The structure of the conjugate was characterized by liquid chromatography-tandem mass spectrometry and NMR experiments. The conjugate formation was primarily catalyzed by heterologously expressed CYP2C19, CYP1A2, and, to a lesser extent, CYP3A4 and CYP3A5. The mechanism for the formation of this conjugate is unknown; however, a tentative bioactivation mechanism involving a P450-catalyzed abstraction of hydrogen atom from the amide nitrogen of flutamide and the subsequent trapping of the nitrogen-centered radical by GSH or oxidized glutathione (GSSG) was proposed. Interestingly, the same adduct was formed when flutamide was incubated with human liver microsomes in the presence of GSSG and NADPH. This finding suggests that P450-mediated oxidation of flutamide via a nitrogen-centered free radical could be one of the several bioactivation pathways of flutamide. Even though the relationship of the GSH conjugate to flutamide-induced toxicity is unknown, the results have revealed the formation of a novel, hitherto unknown, GSH adduct of flutamide.
Trends in Area-Socioeconomic and Race-Ethnic Disparities in Breast Cancer Incidence, Stage at Diagnosis, Screening, Mortality, and Survival among Women Ages 50 Years and Over (1987-2005)

Background: Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer death among women in the United States and varies systematically by race-ethnicity and socioeconomic status. Previous research has often focused on disparities between particular groups, but few studies have summarized disparities across multiple subgroups defined by race-ethnic and socioeconomic position. Methods: Data on breast cancer incidence, stage, mortality, and 5-year cause-specific probability of death (100 − survival) were obtained from the Surveillance, Epidemiology, and End Results program and data on mammography screening from the National Health Interview Survey from 1987 to 2005. We used four area-socioeconomic groups based on the percentage of poverty in the county of residence (<10, 10-15, 15-20, +20%) and five race-ethnic groups (White, Black, Asian, American Indian, and Hispanic). We used summary measures of disparity based on both rate differences and rate ratios. Results: From 1987 to 2004, area-socioeconomic disparities declined by 20% to 30% for incidence, stage at diagnosis, and 5-year cause-specific probability of death, and by roughly 100% for mortality, whether measured on the absolute or relative scale. In contrast, relative area-socioeconomic disparities in mammography use increased by 161%. Absolute race-ethnic disparities declined across all outcomes, with the largest reduction for mammography (56% decline). Relative race-ethnic disparities for mortality and 5-year cause-specific probability of death increased by 24% and 17%, respectively. Conclusions: Our analysis suggests progress towards race-ethnic and area-socioeconomic disparity goals for breast cancer, especially when measured on the absolute scale. However, greater progress is needed to address increasing relative socioeconomic disparities in mammography and race-ethnic disparities in mortality and 5-year cause-specific probability of death. (Cancer Epidemiol Biomarkers Prev 2009;18(1):121–31)
Observed Relationship of Spring and Summer East Asian Rainfall with Winter and Spring Eurasian Snow

Abstract This study investigates the relationship between spring and summer rainfall in East Asia and the preceding winter and spring snow cover/depth over Eurasia, using station rainfall observations, satellite-observed snow cover, satellite-derived snow water equivalent, and station observations of the number of days of snow cover and snow depth. Correlation analysis shows that snow-depth anomalies can persist from winter to spring whereas snow cover anomalies cannot in most regions of Eurasia. Locally, snow cover and snow-depth anomalies in February are not related in most regions to the north of 50°N, but those anomalies in April display consistent year-to-year variations. The results suggest that the winter snow cover cannot properly represent all the effects of snow and it is necessary to separate the winter and spring snow cover in addressing the snow–monsoon relationship. Spring snow cover in western Siberia is positively correlated with spring rainfall in southern China. The circulation anomalies.
Synapsin Utilization Differs among Functional Classes of Synapses on Thalamocortical Cells

Several proteins in nerve terminals participate in synaptic transmission between neurons. The synapsins, which are synaptic vesicle-associated proteins, have widespread distribution in the brain and are assumed essential for sustained recruitment of vesicles during high rates of synaptic transmission. We compared the role of synapsins in two types of glutamatergic synapses on thalamocortical cells in the dorsal lateral geniculate nucleus of mice: retinogeniculate synapses, which transmit primary afferent input at high frequencies and show synaptic depression, and corticogeniculate synapses, which provide modulatory feedback at lower frequencies and show synaptic facilitation. We used electrophysiological methods to determine effects of gene knock-out of synapsin I and II on short-term synaptic plasticity in paired-pulse, pulse-train, and posttetanic potentiation paradigms. The gene inactivation changed the plasticity properties in corticogeniculate, but not in retinogeniculate, synapses. Immunostaining with antibodies against synapsins in wild-type mice demonstrated that neither synapsin I nor II occurred in retinogeniculate terminals, whereas both occurred in corticogeniculate terminals. In GABAergic terminals, only synapsin I occurred. In corticogeniculate terminals of knock-out mice, the density of synaptic vesicles was reduced because of increased terminal size rather than reduced number of vesicles and the intervesicle distance was increased compared with wild-type mice. In the retinogeniculate terminals, no significant morphometric differences occurred between knock-out and wild-type mice. Together, this indicates that synapsin I and II are not present in the retinogeniculate terminals and therefore are not essential for sustained, high-rate synaptic transmission.