Miracle-dz/UniFAR-FTUs huggingface dataset:
Data centres in the ancillary services market

Ancillary services are the mechanisms power grids use to address short-term variability in supply and demand as well as the impact of power plant or transmission line failures. Organizations providing such services can earn revenue, or at least reduce their energy costs. This paper explores options for large data centres to reduce costs in this way. Simulation results are presented for a system that models the processing of a workload and the resulting energy use, focusing on the impact of providing specific types of ancillary services. Trace data recording the workload from three supercomputing facilities along with pricing information from a US-based electrical grid are used. Results presented show energy costs reduced by up to 12% with only a small impact on the quality of service provided to users of the data centre. Further reductions in energy costs are shown for data centres willing to cede more control over short-term energy consumption.
Azacitidine-Induced Interstitial Pneumonitis

Azacitidine is a demethylating and cytotoxic drug for the treatment of adult patients with (1) myelodysplastic syndromes, (2) chronic myelomonocytic leukemia, and (3) acute myeloid leukemia who are not eligible for induction treatment or hematopoietic stem cell transplantation. Widely described in the literature, the main adverse events are hematotoxicity, digestive toxicity, asthenia, cutaneous toxicity, and infections such as neutropenic sepsis and pneumonia. The pivotal phase III comparative and supporting studies did not point out interstitial pneumonitis as a significant adverse event. Rare clinical data from literature report interstitial lung disease secondary to azacitidine administration, which should therefore be considered as a serious potential adverse event. We, herein, report a case of an 86-year-old white woman with acute myeloid leukemia and azacitidine-induced interstitial pneumonitis.
Woven Trellis Coded Modulation with Inner Warp

In this work we address the woven code construction which was introduced for convolutional codes. We extend the inner warp approach for the general use of trellis coded modulation encoded via finite state machine encoders as inner code. In this case a lower bound on the minimum squared Euclidean distance of the overall woven trellis coded modulation can be stated based on the active distances of the outer code and the minimum squared Euclidean distance of the inner code
Making history: intentional capture of future memories

Lifelogging' technology makes it possible to amass digital data about every aspect of our everyday lives. Instead of focusing on such technical possibilities, here we investigate the way people compose long-term mnemonic representations of their lives. We asked 10 families to create a time capsule, a collection of objects used to trigger remembering in the distant future. Our results show that contrary to the lifelogging view, people are less interested in exhaustively digitally recording their past than in reconstructing it from carefully selected cues that are often physical objects. Time capsules were highly expressive and personal, many objects were made explicitly for inclusion, however with little object annotation. We use these findings to propose principles for designing technology that supports the active reconstruction of our future past.
Synthesis and Analgesic Effects of μ-TRTX-Hhn1b on Models of Inflammatory and Neuropathic Pain

μ-TRTX-Hhn1b (HNTX-IV) is a 35-amino acid peptide isolated from the venom of the spider, Ornithoctonus hainana. It inhibits voltage-gated sodium channel Nav1.7, which has been considered as a therapeutic target for pain. The goal of the present study is to elucidate the analgesic effects of synthetic μ-TRTX-Hhn1b on animal models of pain. The peptide was first synthesized and then successfully refolded/oxidized. The synthetic peptide had the same inhibitory effect on human Nav1.7 current transiently expressed in HEK 293 cells as the native toxin. Furthermore, the analgesic potentials of the synthetic peptide were examined on models of inflammatory pain and neuropathic pain. μ-TRTX-Hhn1b produced an efficient reversal of acute nociceptive pain in the abdominal constriction model, and significantly reduced the pain scores over the 40-min period in the formalin model. The efficiency of μ-TRTX-Hhn1b on both models was equivalent to that of morphine. In the spinal nerve model, the reversal effect of μ-TRTX-Hhn1b on allodynia was longer and higher than mexiletine. These results demonstrated that μ-TRTX-Hhn1b efficiently alleviated acute inflammatory pain and chronic neuropathic pain in animals and provided an attractive template for further clinical analgesic drug design.
Improving the pH-stability of Versatile Peroxidase by Comparative Structural Analysis with a Naturally-Stable Manganese Peroxidase

Versatile peroxidase (VP) from the white-rot fungus Pleurotus eryngii is a high redox potential peroxidase of biotechnological interest able to oxidize a wide range of recalcitrant substrates including lignin, phenolic and non-phenolic aromatic compounds and dyes. However, the relatively low stability towards pH of this and other fungal peroxidases is a drawback for their industrial application. A strategy based on the comparative analysis of the crystal structures of VP and the highly pH-stable manganese peroxidase (MnP4) from Pleurotus ostreatus was followed to improve the VP pH stability. Several interactions, including hydrogen bonds and salt bridges, and charged residues exposed to the solvent were identified as putatively contributing to the pH stability of MnP4. The eight amino acid residues responsible for these interactions and seven surface basic residues were introduced into VP by directed mutagenesis. Furthermore, two cysteines were also included to explore the effect of an extra disulfide bond stabilizing the distal Ca2+ region. Three of the four designed variants were crystallized and new interactions were confirmed, being correlated with the observed improvement in pH stability. The extra hydrogen bonds and salt bridges stabilized the heme pocket at acidic and neutral pH as revealed by UV-visible spectroscopy. They led to a VP variant that retained a significant percentage of the initial activity at both pH 3.5 (61% after 24 h) and pH 7 (55% after 120 h) compared with the native enzyme, which was almost completely inactivated. The introduction of extra solvent-exposed basic residues and an additional disulfide bond into the above variant further improved the stability at acidic pH (85% residual activity at pH 3.5 after 24 h when introduced separately, and 64% at pH 3 when introduced together). The analysis of the results provides a rational explanation to the pH stability improvement achieved.
(K)eine Frage des Alters – Fremdsprachenunterricht auf der Primarstufe

Als Argument fur den Fremdsprachenunterricht auf der Primarstufe wird in bildungspolitischen Diskussionen haufig auf die Kurzformel "je junger, desto besser" zuruckgegriffen. Auf der Basis aktueller Beitrage zum Faktor 'Alter' beim Zwei tsprachenerwerb und beim Fremdsprachenlernen, die unterschiedlich relevant fur Fremdsprachenunterricht sind, geht dieser Beitrag der Frage nach, ob unter den gegebenen schulischen Bedingungen das jungere Einstiegsalter als Argument herangezogen werden kann. Dabei wird gezeigt, dass der Faktor 'Alter' allein sich weder als Argument fur den Beginn des Fremdsprachenunterrichts noch als Richtschnur seiner methodischen Gestaltung eignet. Die vorliegende Forschung deutet darauf hin, dass der Faktor 'Alter' mit einer Reihe anderer relevanter Faktoren verknupft ist. Dabei werden spezifische Bedingungen und Anforderungen junger Fremdsprachenlerner deutlich, die bei der Planung und Durchfuhrung berucksichtigt werden sollten. In discussions about foreign language learning in primary school, the truism ‘the younger the better’ is often voiced. In the light of recent research into the ‘age factor’ in second language acquisition and foreign language learning, regarded as two distinct processes, this paper discusses whether age of onset may be a valid argument in favour of early foreign language teaching in school. The article will draw attention to evidence indicating that age is related to a multiplicity of other determinants which, taken together, form a complex of inter-related and interacting factors. This complexity underlines the importance of taking into account the specific circumstances and needs of young learners when planning and delivering foreign language teaching. Schlagworter: Faktor 'Alter', Fremdsprachenlernen in der Grundschule, Fremdsprachenunterricht in der Grundschule, critical period hypothesis, Strategienentwicklung. 1. Je junger, desto besser – Fremdsprachenunterricht auf der Primarstufe eine Frage des Alters In seinem einleitenden Beitrag zu einem Sammelband, der aus der wissenschaftlichen Evaluation des flachendeckend neu eingefuhrten Fremdsprachenunterrichts Englisch in der Grundschule in Nordrhein-Westfalen erwachsen ist (Engel, Groot-Wilken & Thurmann (Hrsg.) 2009), stellt Thurmann (2009: 5) fest, dass das "Potenzial des fruhen kindgemasen Lehrens und Lernens von Sprachen [. ] bei Weitem noch nicht vollstandig erschlossen" sei. Dazu seien noch einige Anstrengungen zum Beispiel in der Lehrerbildung notwendig. "Erforderlich ist auch eine von den Ergebnissen der Sprachlehrund -lernforschung gestutzte radikale Auseinandersetzung mit den Mythen und Orthodoxien zur Didaktik und Methodik des kindgemasen Fremdsprachenunterrichts" (Thurmann 2009: 5). Ein mit Blick auf den fruhen Fremdsprachenunterricht besonders langlebiger und einflussreicher Mythos – sowohl hinsichtlich bildungspolitischer Entscheidungsprozesse als auch hinsichtlich methodisch-didaktischer Fragestel-
Interface, a dispersed architecture

Past and current specification techniques use timing diagrams and written text to describe the phenomenology of an interface. This paper treats an interface as the architecture of a number of processes, which are dispersed over the related system parts and the message path. This approach yields a precise definition of an interface. With this definition as starting point, the inherent structure of an interface is developed. A horizontal and vertical partitioning strategy, based on one functional entity per partition and described by a state description, is used to specify the structure. This method allows unambiguous specification, interpretation, and implementation, and allows a much easier judgement of the quality of an interface. The method has been applied to a number of widely used interfaces.
Development of a novel frailty index to predict mortality in patients with end‐stage liver disease

Cirrhosis is characterized by muscle wasting, malnutrition, and functional decline that confer excess mortality not well quantified by the Model for End‐Stage Liver Disease (MELD) Sodium (MELDNa) score. We aimed to develop a frailty index to capture these extrahepatic complications of cirrhosis and enhance mortality prediction in patients with cirrhosis. Consecutive outpatients listed for liver transplantation at a single transplant center without MELD exceptions were assessed with candidate frailty measures. Best subset selection analyses with Cox regression identified subsets of frailty measures that predicted waitlist mortality (=death or delisting because of sickness). We selected the frailty index by balancing statistical accuracy with clinical utility. The net reclassification index (NRI) evaluated the %patients correctly reclassified by adding the frailty index to MELDNa. Included were 536 patients with cirrhosis with median MELDNa of 18. One hundred seven (20%) died/were delisted. The final frailty index consisted of: grip strength, chair stands, and balance. The ability of MELDNa and the frailty index to correctly rank patients according to their 3‐month waitlist mortality risk (i.e., concordance‐statistic) was 0.80 and 0.76, respectively, but 0.82 for MELDNa+frailty index together. Compared with MELDNa alone, MELDNa+frailty index correctly reclassified 16% of deaths/delistings (P = 0.005) and 3% of nondeaths/delistings (P = 0.17) with a total NRI of 19% (P < 0.001). Compared to those with robust frailty index scores (<20th percentile), cirrhotics with poor frailty index scores (>80th percentile) were more impaired by gait speed, difficulty with Instrumental Activities of Daily Living, exhaustion, and low physical activity (P < 0.001 for each). Conclusion: Our frailty index for patients with cirrhosis, comprised of three performance‐based metrics, has construct validity for the concept of frailty and improves risk prediction of waitlist mortality over MELDNa alone. (Hepatology 2017;66:564–574).
Emergence of Fluoroquinolone-Resistant Haemophilus influenzae Strains among Elderly Patients but Not among Children

ABSTRACT We screened 457 Haemophilus influenzae strains isolated in Japan during 2002 to 2004 and identified 12 fluoroquinolone-resistant strains (2.6%). The resistant strains were divided into three genotypes (eight, three, and one of each type). These were isolated from patients over 58 years of age. Several fluoroquinolone-resistant clones appeared to have invaded the population of elderly patients in a particular area, Sapporo city.
The Riemann Hypothesis : Arithmetic and Geometry

This paper describes basic properties of the Riemann zeta function and its generalizations, indicates some of geometric analogies, and presents various formulations of the Riemann hypothesis. It briefly discusses the approach of A. Connes to a “spectral” interpretation of the Riemann zeros via noncommuative geometry, which is treated in detail by Paula Tretkoff [33].
Impact of pediatric chronic pain on siblings: Evidence and theory

Pediatric chronic pain is a complex health problem with far reaching effects on the whole family unit, including siblings. Having a brother or sister with a chronic pain condition renders siblings not only more likely to develop a pain condition themselves (Champion, 2013), but has also been found to have significant effects on the sibling's own functioning (Guite et al., 2007). The current article will describe the nature of the impact of chronic pain on siblings. The mechanism and theories that have been proposed to account for these associations will then be overviewed, giving consideration to both environmental and genetic influences.
Relations of Body Esteem Factors with Exercise Session Attendance in Women Initiating a Physical Activity Program

Based on tenets of cognitive behavioral and social cognitive theory, the association of change in body-esteem factors and attendance in a newly initiated, 12-wk. cardiovascular exercise program was estimated in women (age range = 21 to 60 years, M = 41.4, SD = 12.2). For the group given the exercise program (n = 48), there were significant positive changes on the Weight Control and Physical Condition scores of the Body Esteem Scale at 12 weeks, but not on Sexual Attractiveness scores. For the no-exercise control group (n = 30), no significant changes were found on any of the Body Esteem Scale subscales. For the exercise group, regression analyses indicated between 8% and 9% of the variance in exercise session attendance was accounted for by the changes in scores on each of the three subscales. Entering age into multiple regression equations did not increase the explained variances in attendance. The fit of the findings within behavioral theory, implications for change in exercise behavior, and the need for replication and extension were discussed.
Isotopic Evidence of Cr Partitioning into Earth’s Core

Chromium isotopes in meteorites reveal Earth’s accretion history. The distribution of chemical elements in primitive meteorites (chondrites), as building blocks of terrestrial planets, provides insight into the formation and early differentiation of Earth. The processes that resulted in the depletion of some elements [such as chromium (Cr)] in the bulk silicate Earth relative to chondrites, however, remain debated between leading candidate causes: volatility versus core partitioning. We show through high-precision measurements of Cr stable isotopes in a range of meteorites, which deviate by up to ~0.4 per mil from those of the bulk silicate Earth, that Cr depletion resulted from its partitioning into Earth’s core, with a preferential enrichment in light isotopes. Ab initio calculations suggest that the isotopic signature was established at mid-mantle magma ocean depth as Earth accreted planetary embryos and progressively became more oxidized.
[A comparative study on p53 gene mutation in primary human Dukes C colon cancer with that in matched lymph node metastasis].

OBJECTIVE To study the relationship between metastasis of colon cancer and the mutation of p53 gene. METHODS PCR-SSCP was used to analyse exon 5-9 of the p53 gene in 73 cases of Dukes C human primary cancer and 40 cases of matched lymph node metastasis. RESULTS Mutations were identified in 27 of 73 primary cancers (37%) and 19 of 40 lymph node metastasis (47.5%) with the overall incidence of p53 mutation being 44%. In 21 of 40 cases in which both primary and metastatic cancers were analysed by SSCP, we found no p53 mutations in both lesions. While the same exon and exactly the same mutated band pattern could be seen both in primary and metastatic cancers in another 12 cases (30%). In addition, the agreement of p53 mutation status in primary cancer to the lymph node metastases was lost in the remaining 7 cases (17.5%). All of the 7 cases were confirmed to have base substitution mutations by DNA direct sequencing. In 5 of 7 individuals, the point mutations were detected only in lymph node metastases but not in the primary cancers and in 2 of 7 cases, two exons were found to have mutations in lymph node metastases while only one or no mutation was identified in the primary cancers. CONCLUSION Most p53 mutations occurred before metastasis and p53 mutations persist throughout the final stage of the progression and metastasis in colon cancer. Furthermore, the metastasis of colon cancer is accompanied by the emergence of new mutation in p53 gene or metastasis is selected against the p53 mutation, which suggests that the mutations in p53 gene may be related to the metastasis of colon cancer.
Pervasive computing and an aging populace: Methodological challenges for understanding privacy implications

Purpose – The purpose of this paper is to describe some of the methodological challenges of investigating privacy and ubiquitous computing in the home, particularly among the healthy elderly.Design/methodology/approach – The paper is based on focus groups with 60 senior citizens either living independently or in an assisted living facility. Prototypes of home‐based ubiquitous computing devices were created and deployed in a home‐like living lab setting; elders were brought to the lab to interact with the prototypes, then brought together in focus groups to discuss their insights and concerns.Findings – Initial analyses suggest that extant metaphors of privacy may be inadequate for understanding pervasive computing in the home. Concepts of data, affective concerns, and the creation of appropriate prototypes for eliciting privacy are considered. Considerations for future studies of the elderly and privacy are made.Research limitations/implications – The homogeneity of the study population in terms of socioe.
Premedication in children undergoing day-care surgery.

An oral preparation of dichloralphenazone and paracetamol (Paedosed) was used as an alternative premedication to i.m. morphine and atropine in 562 children undergoing day-care surgery. From a series of observations made, both in hospital and at home, it appears that morphine has several disadvantages when compared with this mixture, provided that the latter is supplemented with i.v. analgesia for the more painful procedures.
Making the best of data derived from a daily practice in clinical legal medicine for research and practice - the example of Spe3dLab

Forensic science suffers from a lack of studies with high-quality design, such as randomized controlled trials (RCT). Evidence in forensic science may be of insufficient quality, which is a major concern. Results from RCT are criticized for providing artificial results that are not useful in real life and unfit for individualized prescription. Various sources of collected data (e.g. data collected in routine practice) could be exploited for distinct goals. Obstacles remain before such data can be practically accessed and used, including technical issues. We present an easy-to-use software dedicated to innovative data analyses for practitioners and researchers. We provide 2 examples in forensics. Spe3dLab has been developed by 3 French teams: a bioinformatics laboratory (LaTIM), a private partner (Tekliko) and a department of forensic medicine (Jean Verdier Hospital). It was designed to be open source, relying on documented and maintained libraries, query-oriented and capable of handling the entire data process from capture to export of best predictive models for their integration in information systems. Spe3dLab was used for 2 specific forensics applications: i) the search for multiple causal factors and ii) the best predictive model of the functional impairment (total incapacity to work, TIW) of assault survivors. 2,892 patients were included over a 6-month period. Time to evaluation was the only direct cause identified for TIW, and victim category was an indirect cause. The specificity and sensitivity of the predictive model were 99.9% and 90%, respectively. Spe3dLab is a quick and efficient tool for accessing observational, routinely collected data and performing innovative analyses. Analyses can be exported for validation and routine use by practitioners, e.g., for computer-aided evaluation of complex problems. It can provide a fully integrated solution for individualized medicine.