Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Different Exercise Modes on Arterial Stiffness and Nitric Oxide Synthesis

PurposeAerobic training (AT) and high-intensity intermittent training (HIIT) reduce arterial stiffness, whereas resistance training (RT) induces deterioration of or no change in arterial stiffness. However, the molecular mechanism of these effects of different exercise modes remains unclear. This study aimed to clarify the difference of different exercise effects on endothelial nitric oxide synthase (eNOS) signaling pathway and arterial stiffness in rats and humans. MethodsIn the animal study, forty 10-wk-old male Sprague–Dawley rats were randomly divided into four groups: sedentary control (CON), AT (treadmill running, 60 min at 30 m·min−1, 5 d·wk−1 for 8 wk), RT (ladder climbing, 8–10 sets per day, 3 d·wk−1 for 8 wk), and HIIT (14 repeats of 20-s swimming session with 10-s pause between sessions, 4 d·wk−1 for 6 wk from 12-wk-old) groups (n = 10 in each group). In the human study, we confirmed the effects of 6-wk HIIT and 8-wk AT interventions on central arterial stiffness and plasma nitrite/nitrate level in untrained healthy young men in randomized controlled trial (HIIT, AT, and CON; n = 7 in each group). ResultsIn the animal study, the effect on aortic pulse wave velocity (PWV), as an index of central arterial stiffness, after HIIT was the same as the decrease in aortic PWV and increase in arterial eNOS/Akt phosphorylation after AT, which was not changed by RT. A negative correlation between aortic PWV and eNOS phosphorylation was observed (r = −0.38, P < 0.05). In the human study, HIIT- and AT-induced changes in carotid–femoral PWV (HIIT −115.3 ± 63.4 and AT −157.7 ± 45.7 vs CON 71.3 ± 61.1 m·s−1, each P < 0.05) decreased, and plasma nitrite/nitrate level increased compared with those in CON. ConclusionsHIIT may reduce central arterial stiffness via the increase in aortic nitric oxide bioavailability despite it being done in a short time and short term and has the same effects as AT.
Flow diversion beyond the circle of Willis: endovascular aneurysm treatment in peripheral cerebral arteries employing a novel low-profile flow diverting stent

Background Flow diversion (FD) has emerged as superior minimally invasive therapy for cerebral aneurysms. However, aneurysms of small peripheral vessel segments have not yet been adequately treatable. More specifically, currently established devices necessitate large microcatheters which impede atraumatic maneuvering. The Silk Vista Baby (SVB), a novel flow diverter, offers the as yet unique feature of deliverability via a 0.017 inch microcatheter. This study reports our first experience with the SVB in challenging intracranial vessels employing a vessel-specific tailored microcatheter strategy. Materials and methods 25 patients (27 aneurysms) were prospectively included. A total of 30 SVBs were employed, predominantly targeting demanding aneurysms of the anterior communicating artery complex. The efficacy of the FD was assessed using two-dimensional vector-based perfusion and conventional digital subtraction angiography (DSA) after implantation and at the first follow-up at 3 months. The first follow-up was available in 22 patients. Results All devices were implanted without technical or clinical complications. Eleven treatments were performed using the recommended Headway 17. In 14 interventions the even more maneuverable Excelsior SL10 was used, which was previously tried and tested for safety ’in vitro’ as an alternative delivery system. Aneurysmal influx was strongly reduced after implantation. All parent vessels remained patent. 17/27 aneurysms were completely occluded at first follow-up (∼2.7 months), 6/27 aneurysms showed decreased influx or delayed washout and one remained unchanged. In three cases follow-up DSAs are remaining. Conclusions SVB provides enhanced controllability in vulnerable segments beyond the circle of Willis. Smaller variants (2.25 mm and 2.75 mm) can safely be implanted via the superiorly navigable Excelsior SL10. Hence, the SVB represents the next evolutionary step in minimally invasive treatment of cerebral aneurysms.
Crumbs protein homolog 3 (CRB3) expression is associated with oestrogen and progesterone receptor positivity in breast cancer

The crumbs protein homolog 3 (CRB3) regulates the tight junction to help maintain epithelial polarity. Altered CRB3 expression was associated with carcinogenesis of epithelial cells. This study detected CRB3 expression in 192 cases of breast cancer tissues and in the Molecular Taxonomy of Breast Cancer International Consortium (Metabric) and The Cancer Genome Atlas (TCGA) datasets for association with triple negative breast cancer (TNBC) phenotypes. The in vitro experiments confirm the ex vivo data. The data showed that levels of both CRB3 mRNA and protein were associated with TNBC phenotypes, ie, 41.1% (39/95) of ER+ breast cancer was CRB3‐positive, whereas 26.9% (25/93) ER– tumour was CRB3‐positive (P = 0.046). Moreover, 47.6% (30/63) of PR+ breast cancer was CRB3‐positive vs 28.4% (33/116) PR‐ tumours positive for CRB3 (P = 0.013). In addition, 40.1% (27/66) of ER+/PR+ tumour was CRB3‐positive, but only 22.4% (19/85) of TNBC showed CRB3 expression (P = 0.048). Indeed, levels of CRB3 mRNA were higher in non‐TNBC than TNBC in both Metabric (P = 3.682e‐10) and TCGA datasets (P = 2.501e‐07). The in vitro data showed that CRB3 expression was higher in luminal (MCF7 and T47D) than in HER2 (MDA‐MB‐453 and SK‐BR‐3) and basal (MDA‐MB‐231 and BT‐549) breast cancer cell lines. More interestingly, ERα regulated expression of CRB3 protein in MCF7 and BT‐549 cells and ERα expression was associated with CRB3 expression in breast cancer tissues specimens. This study demonstrated that ERα could be a novel regulator for CRB3 expression in breast cancer.
Pain and Opioid Use in Chronic Pancreatitis

Objective Opioid therapy for pain in chronic pancreatitis (CP) is associated with tolerance and possibly opioid-induced hyperalgesia. We thus examined opioid use and pain rating in CP patients. Methods Medical records of patients with established CP treated at the University of Pittsburgh Medical Center’s Digestive Disorders Center between April 2008 and December 2009 were retrospectively reviewed. Results Two hundred nineteen unique patients (53% men; age, 50 ± 1 years) were identified. At least moderate pain was initially present in 37% of the patients. Half (51%) of the patients received opioids (average morphine equivalent, 78.1 ± 12.4 mg/d). Pain severity correlated with age (r2 = −0.22), history of alcohol abuse (r2 = 0.14), affective spectrum disorders (r2 = 0.14), presence of coexisting pain syndromes (r2 = 0.24), opioid use (r2 = 0.49), and days with concerns about physical (r2 = 0.55) or mental problems (r2 = 0.35). In contrast, computed tomography–defined pancreatic abnormalities (calcification, pseudocysts, ductal stones, or dilation) did not correlate with pain rating. Regression analysis identified age, days with physical problems, and a coexisting chronic pain syndrome as best independent predictors of pain. Conclusions Chronic pancreatitis etiology, especially alcohol use, and psychosocial factors are important determinants of pain severity in CP. Successful management thus needs to go beyond treatment of changes in pancreatic morphology to effectively improve quality of life and utilization of medical resources.
Venous Sinus Stenosis Causing Isolated Pulsatile Tinnitus

A 61-year-old man was referred to the neurology clinic due to a persistent, disabling, right-sided pulsatile tinnitus (PT), which he noticed 4 years before and had recently worsened. The tinnitus ameliorated with manual pressure over the ipsilateral cervical region and cervical ﬂ exion to the right side. With the exception of an audible high-pitch bruit below the right mastoid process, the neurological examination was unremarkable. After careful evaluation, computed tomography angiography and magnetic resonance imaging showed a stenosis in the right lateral venous sinus (Figure 1A – C). Lumbar puncture revealed an intracranial pressure of 12 cmH 2 O. The presence of a stenosis-associated pressure gradient was con ﬁ rmed in digital subtraction angiography (9 mmHg), by using a co-axial system consisting of a NeuronMax 0.88 long sheath (placed in the right internal jugular vein) and a 0.021 ” microcatheter positioned on the superior sagittal sinus (Prowler Select Plus). Following multidisciplinary discussion and patient agreement, recalibration of the venous sinus was successfully performed with a nontapered X-Act stent (9 x 30 mm) (Figure 1D – E), after progression along a microguidewire Synchro 0.014 ” . Tinnitus resolved immediately after the procedure, and it had not recurred at the 6-month follow-up. Only of all patients it in nature. namely, intracranial
Hyperglycemia Enhances Constriction of Retinal Venules via Activation of the Reverse-Mode Sodium-Calcium Exchanger

Diabetes is associated with hyperglycemia and impairment of retinal microvascular function. However, the impact of hyperglycemia on retinal venular constriction remains unknown. We examined retinal venular responsiveness to endogenous vasoconstrictors and the contribution of the reverse-mode sodium-calcium exchanger (NCX) to these responses during hyperglycemia. Retinal venules were isolated from pigs with streptozocin-induced diabetes (2 weeks, in vivo hyperglycemia) and age-matched control pigs for vasoreactivity and molecular studies. For in vitro hyperglycemia, vessels from euglycemic pigs were exposed to high glucose (25 mmol/L) for 2 h, and 5 mmol/L glucose served as the control. Constrictions of venules from euglycemic pigs to endothelin-1 (ET-1), thromboxane analog U46619, and norepinephrine were mediated by ETA, thromboxane, and α2-adrenergic receptors, respectively, and were insensitive to reverse-mode NCX blockade (KB-R7943). In vivo hyperglycemia enhanced these vasoconstrictions without altering respective receptor mRNA expression. Similarly, in vitro hyperglycemia augmented venular constrictions. Enhanced vasoconstrictions during hyperglycemia were prevented by KB-R7943, while mRNA expression of venular NCX isoforms was unaltered. In vivo hyperglycemia increased vitreous levels of ET-1 but not thromboxane B2. In conclusion, both in vitro and in vivo hyperglycemia enhance retinal venular responses to endogenous vasoconstrictors by activating reverse-mode NCX. Therapies targeting this vascular molecule may alleviate retinal complications during diabetes.
A Human-Centered Approach to Interactive Machine Learning

The interactive machine learning (IML) community aims to augment humans' ability to learn and make decisions over time through the development of automated decision-making systems. This interaction represents a collaboration between multiple intelligent systems---humans and machines. A lack of appropriate consideration for the humans involved can lead to problematic system behaviour, and issues of fairness, accountability, and transparency. This work presents a human-centred thinking approach to applying IML methods. This guide is intended to be used by AI practitioners who incorporate human factors in their work. These practitioners are responsible for the health, safety, and well-being of interacting humans. An obligation of responsibility for public interaction means acting with integrity, honesty, fairness, and abiding by applicable legal statutes. With these values and principles in mind, we as a research community can better achieve the collective goal of augmenting human ability. This practical guide aims to support many of the responsible decisions necessary throughout iterative design, development, and dissemination of IML systems.
On the Gibbs-Liouville theorem in classical mechanics

In this article, it is argued that the Gibbs-Liouville theorem is a mathematical representation of the statement that closed classical systems evolve deterministically. From the perspective of an observer of the system, whose knowledge about the degrees of freedom of the system is complete, the statement of deterministic evolution is equivalent to the notion that the physical distinctions between the possible states of the system, or, in other words, the information possessed by the observer about the system, is never lost. Thus, it is proposed that the Gibbs-Liouville theorem is a statement about the dynamical evolution of a closed classical system valid in such situations where information about the system is conserved in time. Furthermore, in this article it is shown that the Hamilton equations and the Hamilton principle on phase space follow directly from the differential representation of the Gibbs-Liouville theorem, i.e. that the divergence of the Hamiltonian phase flow velocity vanish. Thus, considering that the Lagrangian and Hamiltonian formulations of classical mechanics are related via the Legendre transformation, it is obtained that these two standard formulations are both logical consequences of the statement of deterministic evolution, or, equivalently, information conservation.
Differential Structure of Inductive Proximity Sensor

The inductive proximity sensor (IPS) is applicable to displacement measurements in the aviation field due to its non-mechanical contact, safety, and durability. IPS can increase reliability of position detection and decrease maintenance cost of the system effectively in aircraft applications. Nevertheless, the specialty in the aviation field proposes many restrictions and requirements on the application of IPS, including the temperature drift effect of the resistance component of the IPS sensing coil. Moreover, reliability requirements of aircrafts restrict the use of computational-intensive algorithms and avoid the use of process control components. Furthermore, the environment of airborne electronic equipment restricts measurements driven by large current and proposes strict requirements on emission tests of radio frequency (RF) energy. For these reasons, a differential structured IPS measurement method is proposed in this paper. This measurement method inherits the numerical separation of the resistance and inductance components of the IPS sensing coil to improve the temperature adaptation of the IPS. The computational complexity is decreased by combining the dimension-reduced look-up table method to prevent the use of process control components. The proposed differential structured IPS is equipped with a differential structure of distant and nearby sensing coils to increase the detection accuracy. The small electric current pulse excitation decreases the RF energy emission. Verification results demonstrate that the differential structured IPS realizes the numerical decoupling calculation of the vector impedance of the sensing coil by using 61 look-up table units. The measuring sensitivity increased from 135.5 least significant bits (LSB)/0.10 mm of a single-sensing-coil structured IPS to 1201.4 LSB/0.10 mm, and the linear approximation distance error decreased from 99.376 μm to −3.240 μm. The proposed differential structured IPS method has evident comparative advantages compared with similar measuring techniques.
Noncoherent Orthogonal Distributed Space-Time Block Codes for Amplify-and-Forward Half-Duplex Cooperative Relay Channels

In this paper, the design of a simple orthogonal distributed space-time block code for a noncoherent amplify-and-forward (AF) half-duplex cooperative relay system is proposed by utilizing a pair of coprime phase-shift keying (PSK) constellations and the Alamouti coding scheme. It is shown that one significant advantage of such design is that, in a noise-free case, for any given nonzero received signals, the channel coefficients and the transmitted signals can be blindly and uniquely determined with a simple closed-form solution. The other significant advantage is that, in a noise case, the least square error (LSE) receiver also has a simple closed-form solution to jointly estimate the channel and the transmitted signals. Simulation results show that our proposed scheme obtains a significant gain of signal-to-noise ratio over the training scheme.
Vaccination-Related Activities at Schools With Kindergartners: Evidence From a School Nurse Survey

Vaccination coverage among children in kindergarten varies across the country and within states. We surveyed a convenience sample of kindergarten school nurses to investigate self-reported vaccination-related activities conducted at schools nationwide. The majority of the 1,435 kindergarten school nurses responding reported that their schools communicate with parents and guardians of undervaccinated students by phone (96%), postal mail (67%), newsletters (61%), and e-mail (59%). Most respondents reported documenting vaccination coverage in electronic systems (85%) and sharing coverage reports with health departments (69%). A total of 41% of school nurses worked with external partners for vaccination efforts, the most common support received from partners being vaccine administration (38%) and providing materials/vaccines (21%). School nurses also reported that 95% of kindergartners were up to date for all vaccines. School-based vaccination-related activities are essential to sustaining high levels of vaccination coverage for the protection of children at schools and in the broader community.
Biochemical markers of time since death in cerebrospinal fluid: A first step towards “Forensomics”

Abstract The accurate estimation of the time of death is a challenge in forensic medicine, as the methods routinely used to assess the postmortem interval (PMI) are far from being precise. Over the past decades, biochemical methods have been implemented on postmortem samples to improve the precision of PMI estimation. Studies have focussed on the biochemical profiles of closed compartment body fluids, as they are preserved longer than blood after death and are thus subject to confined postmortem chemical changes. Cerebrospinal fluid (CSF) has been considered a suitable fluid to investigate these changes, as it is found in large amounts and is easy to sample. Moreover, the main molecules found in CSF have known reference values in living subjects, unlike most other body fluids. In this literature review, we focus on the panel of biomarkers that have been studied in CSF based on their potential of offering information on the time of death. The interest in these biomarkers for casework and the research perspectives in this field are discussed. Integrating data from different methods, including biochemistry, for better estimation of the time of death would represent a step forward in the forensic field, paving the way for an innovative approach that we suggest to call “Forensomics. ”
Size of 1-Error-Detecting Codes in Three Interactive Transmissions

This paper considers the error-detecting codes between two nodes. There are three transmissions between these two nodes: node A and node B. The first transmission can transmit one symbol within the alphabet {0, 1, . , q1-1} from node A to node B; the second transmission can transmit one symbol within the alphabet {0, 1, . , q2-1} from node B to node A; and the third transmission can transmit one symbol within the alphabet {0, 1, . , q3-1} from node A to node B. One of the three transmissions may be erroneous. We prove that the maximum size of all 1-error-detecting codes over these three transmissions is min{q1, q2(q3-1)}.
Enhancing the settling time estimation of a class of fixed‐time stable systems

In this paper, we provide a new nonconservative upper bound for the settling time of a class of fixed‐time stable systems. To expose the value and the applicability of this result, we present four main contributions. First, we revisit the well‐known class of fixed‐time stable systems, to show the conservatism of the classical upper estimate of its settling time. Second, we provide the smallest constant that the uniformly upper bounds the settling time of any trajectory of the system under consideration. Third, introducing a slight modification of the previous class of fixed‐time systems, we propose a new predefined‐time convergent algorithm where the least upper bound of the settling time is set a priori as a parameter of the system. At last, we design a class of predefined‐time controllers for first‐ and second‐order systems based on the exposed stability analysis. Simulation results highlight the performance of the proposed scheme regarding settling time estimation compared to existing methods.
Effects of GABA and Leptin Receptor‐Expressing Neurons in the Lateral Hypothalamus on Feeding, Locomotion, and Thermogenesis

The lateral hypothalamus (LH) is known for its role in feeding, and it also regulates other aspects of energy homeostasis. How genetically defined LH neuronal subpopulations mediate LH effects on energy homeostasis remains poorly understood. The behavioral effects of chemogenetically activating LH gamma‐aminobutyric acid (GABA) and the more selective population of LH GABA neurons that coexpress the leptin receptor (LepR) were compared.
Characteristics Associated with the Postprandial Hypotensive Response in Falling Older Adults

RÉSUMÉ Il a été démontré que l’intensité de la réponse hypotensive postprandiale (RHP) peut constituer un facteur de risque pour les chutes, les fractures et le décès. Bien que ce risque ait été bien établi, les cliniques de chutes font rarement des analyses liées aux repas, en raison de contraintes logistiques. Afin de mieux cibler les patients à risque de RHP parmi les personnes âgées affectées par des chutes, cette étude a examiné les caractéristiques individuelles associées à des RHP plus intenses. Cinquante-deux patients (âge moyen : 77,8 ± 0,9 ans, 29 femmes, 23 hommes) référés par des cliniques de prévention des chutes ont été recrutés pour un repas-test de 90 minutes. Les variables significatives ont ensuite été insérées dans un modèle linéaire multivarié incluant l’âge, le sexe, la présence de diabète, la présence d’hypertension, la pression systolique de base (PSB) et la chute de la PSB orthostatique. Bien que de plus amples recherches soient nécessaires, notre étude suggère que les hommes, les patients présentant une tension artérielle élevée et ceux avec une chute orthostatique pourraient être plus à risque de réponses hémodynamiques postprandiales plus intenses. ABSTRACT The magnitude of the postprandial hypotensive (PPH) response has been shown to be an independent risk factor for falls, fractures, and death. Despite this well-established risk, meal tests are rarely done in the falls clinic setting because of logistical issues. In order to better target potential PPH patients among older falling adults, this study examines which subject characteristics are associated with larger PPH responses. A total of 52 falls clinic patients (mean age 77.8 ± 0.9 years, 29 women, 23 men) were recruited for a 90 minute meal test. Significant variables were then entered into a stepwise multivariate linear model containing age, sex, presence of diabetes, presence of hypertension, baseline systolic blood pressure (SBP), and the orthostatic drop in SBP. Although further work is required, our study suggests that men, patients with higher blood pressure, and patients with an orthostatic drop might be more likely to have higher postprandial hemodynamic responses.