Miracle-dz/UniFAR-FTUs huggingface dataset:
Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells

Members of the inhibitor of apoptosis protein (IAP) family play a role in mediating apoptosis. Studies suggest that these proteins may be a viable target in leukemia because they have been found to be variably expressed in acute leukemias and are associated with chemosensitivity, chemoresistance, disease progression, remission, and patient survival. Another promising therapeutic target, FLT3, is mutated in about one third of acute myelogenous leukemia (AML) patients; promising results have recently been achieved in clinical trials investigating the effects of the protein tyrosine kinase inhibitor PKC412 on AML patients harboring mutations in the FLT3 protein. Of growing concern, however, is the development of drug resistance resulting from the emergence of point mutations in targeted tyrosine kinases used for treatment of acute leukemia patients. One approach to overriding resistance is to combine structurally unrelated inhibitors and/or inhibitors of different signaling pathways. The proapoptotic IAP inhibitor, LBW242, was shown in proliferation studies done in vitro to enhance the killing of PKC412-sensitive and PKC412-resistant cell lines expressing mutant FLT3 when combined with either PKC412 or standard cytotoxic agents (doxorubicin and Ara-c). In addition, in an in vivo imaging assay using bioluminescence as a measure of tumor burden, a total of 12 male NCr-nude mice were treated for 10 days with p.o. administration of vehicle, LBW242 (50 mg/kg/day), PKC412 (40 mg/kg/day), or a combination of LBW242 and PKC412; the lowest tumor burden was observed in the drug combination group. Finally, the combination of LBW242 and PKC412 was sufficient to override stromal-mediated viability signaling conferring resistance to PKC412. [Mol Cancer Ther 2007;6(7):1951–61]
Episensitization: Therapeutic Tumor Resensitization by Epigenetic Agents: A Review and Reassessment

Resistance to chemotherapy, biological and targeted therapies is an important clinical problem. Resistance can arise and/or be selected for multiple mechanisms of action. Unfortunately, acquired resistance to antitumor agents or regimens is nearly inevitable in all patients with metastatic disease. Until recently, it was believed that this resistance was unalterable and irreversible, rendering retreatment with the same or similar drugs futile in most cases. However, the introduction of epigenetic therapies, including HDAC inhibitors and DNA methyltransferase inhibitors (DNMTIs), has provided oncologists with new strategies to potentially overcome this resistance. For example, if chemoresistance is the product of multiple non-genetic alterations, which develop and accumulate over time in response to treatment, then the ability to epigenetically modify the tumor to reconfigure it back to its baseline non-resistant state, holds tremendous promise for the treatment of advanced, metastatic cancer. This minireview aims (1) to explore the potential mechanisms by which a group of small molecule agents including HDACs (entinostat and vorinostat), DNA hypomethylating agents such as the DNMTIs (decitabine (DEC), 5-azacytidine (5-AZA)) and redox modulators (RRx-001) may reprogram the tumors from a refractory to non-refractory state, (2) highlight some recent findings in this area, and (3) discuss the therapeutic potential of resensitization approaches with formerly failed chemotherapies.
A review of wearable antenna

Utilization of wearable textiles in the antenna segment has been seen on the rise due to the recent miniaturization of wireless devices. A wearable antenna is meant to be a part of the clothing used for communication purposes, which includes tracking and navigation, mobile computing and public safety. This literature review intend to disclose this unconventional antenna technology and provides readers with the background of the wearable antenna that would include about specification of the antenna, material for the antenna and analysis that must be done to design proper wearable antennas. All the designs presented are of the recent development in wearable technology.
Keyless Authentication in a Noisy Model

We study a keyless authentication problem in a new noisy model, where there is a discrete memoryless channel (DMC) W1 from sender Alice to receiver Bob and a DMC W2 from adversary Oscar to Bob. In addition, there is an insecure noiseless channel between Alice and Bob. Under this model, we characterize the condition under which an authentication from Alice to Bob is possible. We also construct a secure authentication protocol that has an authentication rate approaching infinity. Finally, we prove that the authentication capacity of a noninteractive authentication over binary symmetric channels is exactly 1. This is an interesting result as Shannon capacity of channel W1 is strictly less than 1 while the noiseless channel is completely unreliable.
Water Demand Prediction Model Based on Radial Basis Function Neural Network

Artificial Neural Network (ANN) simulates the structure and function of human brain. It has the abilities of parallel information processing, distributed storage and self-learning and reasoning. ANN features fault tolerance, nonlinearity, nonlocality, nonconvexity, etc., and is suitable for identifying and mapping fuzzy information or complex nonlinear relationship. Combined with the characteristics of domestic water consumption, industry water consumption and agriculture water consumption, the influencing factors are analyzed. A Radial Basis Function (RBF) Neural Network model is established for water demand prediction, using 17 water demand predication factors as input of the network. On output layer, the four nodes include urban household water demand, rural household water demand, industrial water demand and agricultural water demand. Dynamic Clustering Learning algorithm is used to determine RBF width, cluster center, number of nodes in hidden layer and weight. The number of hidden layer determined by network learning is 8. The relative error of three years are 2.74%, 3.33% and 1.41% respectively. The results show that RBF neural network has such advantages that the output is independent the initial weight value and the convergence speed is faster. And a better forecasting result is achieved through such a model.
Back Pain in Poland and Germany: A Survey of Prevalence and Association with Demographic Characters

Background. Back pain is the most common form of pain and leads to high costs in all medical care systems. Objective. The present study examines the prevalence of back pain and its associations with some basic demographics. Methods. Two samples from Poland and Germany (about n = 500 each) were examined via Internet regarding back pain, gender, age, and body mass index (BMI). Results. Back pain is more common in women than in men (risk ratio about 1.7), and a high BMI constitutes an additional risk factor. Age was not related to back pain prevalence. Conclusion. Congruent results in two countries based on the same measure of back pain lead to the assumption that much of the variety found in estimates of back pain are due to inconsistent assessment. For future research, a definition of common criteria on how to assess back pain would be an asset.
Methylglyoxal—A Potential Risk Factor of Manuka Honey in Healing of Diabetic Ulcers

Honey has been considered as a remedy in wound healing since ancient times. However, as yet, there are inadequate supportive robust randomized trials and experimental data to fully accept honey as an effective medical product in wound care. Manuka honey has been claimed to have therapeutic advantages over other honeys. Recently, it has been documented that the pronounced antibacterial activity of manuka honey is due, at least in part, to reactive methylglyoxal (MG). The concentration of MG in manuka honeys is up to 100-fold higher than in conventional honeys. MG is a potent protein-glycating agent and an important precursor of advanced glycation end products (AGEs). MG and AGEs play a role in the pathogenesis of impaired diabetic wound healing and can modify the structure and function of target molecules. This commentary describes the concern that MG in manuka honey may delay wound healing in diabetic patients. Further detailed research is needed to fully elucidate the participation of honey/derived MG in healing diabetic ulcers. We advocate randomized controlled trials to determine efficacy and safety of manuka honey in this population.
Precoder and decoder prediction in time-varying MIMO channels

In wireless communications, mobility can make the available channel information out of date. A timely update of the channel state information is an obvious solution to improve the system performance in a time-varying channel. However, this comes at the cost of a decrease in the system throughput since many pilots have to be inserted. Thus, predicting the future channel conditions can improve not only the performance but also the throughput of many types of wireless systems. This is especially true when multiple antennas are applied at both link ends. In this paper, we propose and evaluate the performance of a prediction scheme for multiple input multiple output (MIMO) systems that apply spatial multiplexing. We aim at predicting the future precoder/decoder directly without going through the prediction of the channel matrix. The results show that in a slowly time-varying channel an increase in the system performance by a factor of two is possible
Confidence Factor Assignment To Translation Templates

CONFIDENCE FACTOR ASSIGNMENT TO TRANSLATION TEMPLATES Zeynep Orhan M S in Computer Engineering and Information Science Supervisor Asst Prof Ilyas C i cekli September TTL Translation Template Learner algorithm learns lexical level correspondences between two translation examples by using analogical reasoning The sentences used as translation ex amples have similar and di erent parts in the source language which must correspond to the similar and di erent parts in the target language Therefore these correspondences are learned as translation templates The learned translation templates are used in the translation of other sentences However we need to assign con dence factors to these translation templates to order translation results with respect to previously assigned con dence factors This thesis proposes a method for assigning con dence factors to translation templates learned by the TTL algo rithm In this process each template is assigned a con dence factor according to the statistical information obtained from training data Furthermore some template combinations are also assigned con dence factors in order to eliminate certain combinations resulting bad translation
Real-time estimator of Laser Doppler Anemometer signal parameters based on Kalman filtering

In order to develop a cheap and reliable way of measuring an aircraft's speed, the French aerospace laboratory, ONERA, has designed a new Laser Doppler Anemometer (LDA) based on coherent detection [10]. A laser beam is generated in the vicinity of the aircraft. An aerosol particle passing through the laser volume scatters light according to its velocity. Back-scattered signal consists of a Gaussian shaped time-varying amplitude modulated by a sinusoidal signal. Its envelope and its phase carry the speed information. Because of speed requirements signal processing, a simple real-time estimator, based on Kalman filtering, is proposed in this study.
A New Approach for Traffic Management in Wireless Multimedia Sensor Network

Multimedia applications have become an essential part of our daily lives, and their use is flourishing day by day. In Wireless Multimedia Sensor Networks (WMSNs), large volume of multimedia data is transmitted through the network. If the traffic load is greater than the available capacity of the sensor network, congestion occurs and it causes buffer overflow, packet drop, deterioration of network throughput and effect quality of service (QoS). The limited bandwidth should be adjusted for the packets with different priorities precisely. To emphasize the problem, the paper provides A New Approach for Traffic Management in Wireless Multimedia Sensor Network. According to the paper, sensor nodes in one collision area can adjust their sending states adaptively based on packet priority. To improve the received video quality in base stations, proposed technique keeps the I-frames and ignores the other less important frame types of compressed video. Also retransmissions of lost packets are provided with different priorities for enhancing the system performance. The simulations show that the bandwidth adjustment can protect the packets with high priority effectively, and the performance of the retransmission is well positioned to meet the requirement of the multimedia applications. MATLAB is used for simulation purpose.
Divisions of Labor: Gender, Power, and Later Medieval Childbirth, c. 1200–1500

In the past generation, a substantial amount of scholarship has emerged in connection with the once-neglected subject of childbirth in the later Middle Ages. While engaging with a wide variety of sources, its historians have shown a consistent interest in childbirth's role in gender relations that draws strength from contemporary debates in women's history and gender history. Over the past 30 years, their work has generally shifted from idealization of medieval childbirth as a realm of female autonomy to a more nuanced consideration of the roles and interests of men in the birthing chamber. However, the field remains fragmented, with scholars often reaching contrary conclusions depending on the sources they utilize. This article surveys academic work on later medieval childbirth published over the past three decades. It reviews research from five major areas of inquiry: medical practitioners and knowledge, secular and canon law, art and material history, texts and ritual, and miracle accounts. By way of conclusion, it considers both the prospects for reuniting these areas into a synthetic whole and the role gender might play in doing so.
Prior Knowledge, Older Age, and Higher Allowance Are Risk Factors for Self-Medication with Antibiotics among University Students in Southern China

Background Self-medication with antibiotics (SMA) has been reported among university students in many countries, but little research has been done on this issue in China. The objective of this study was to evaluate knowledge and behaviors of university students and risk factors concerning SMA. Methodology/Principal Findings Using a novel questionnaire-based data collection instrument, an anonymous online survey was conducted with the students of Shantou University (STU), a university comprising 8 schools/colleges in eastern Guangdong, China. Of 1,300 respondents (13.8% of total eligible participants), 47.8% had self-treated with antibiotics. Logistic regression analysis identified prior knowledge of antibiotics (PKA), older age, and higher monthly allowance as independent risk factors for SMA. PKA significantly influenced students' knowledge about antibiotics, their uses, and common adverse reactions (all p<0.05). Among self-medicated students, 61.7% used antibiotics at least twice in the previous year. Community pharmacies were the major source of self-prescribed antibiotics. Reported common indications for SMA were sore throat (59.7%), fever (38.2%), cough (37.4%), runny nose (29.3%), and nasal congestion (28.7%). While 74.1% of self-medication episodes were based on students' own experiences, only 31.1% of students claimed to understand the package insert. Alteration of antibiotics and dosage during the course of self-treatment was made by 63.8% and 55.6% of students, respectively. At least two kinds of antibiotics were simultaneously taken by 82.6% of students. The majority of self-medicated students failed to complete the course of antibiotics. Adverse reactions were reported by 16.3% of students. Amoxicillin was the most common antibiotic used for self-medication. Conclusions High prevalence of SMA was noted among STU students. Presence of risk factors and risk-associated behaviors/attitudes in the study population calls for focused educational intervention and stricter governmental legislation and regulation of antibiotic use and sale in pharmacies.
Batch Resizing Policies and Techniques for Fine- Grain Grid Tasks: The Nuts and Bolts

The overhead of processing fine-grain tasks on a grid induces the need for batch processing or task group deployment in order to minimise overall application turnaround time. When deciding the granularity of a batch, the processing requirements of each task should be considered as well as the utilisation constraints of the interconnecting network and the designated resources. However, the dynamic nature of a grid requires the batch size to be adaptable to the latest grid status. In this paper, we describe the policies and the specific techniques involved in the batch resizing process. We explain the nuts and bolts of these techniques in order to maximise the resulting benefits of batch processing. We conduct experiments to determine the nature of the policies and techniques in response to a real grid environment. The techniques are further investigated to highlight the important parameters for obtaining the appropriate task granularity for a grid resource.
The Effect of Supplementing Instruction with Conceptual Change Texts on Students' Conceptions of Electrochemical Cells

The aim of this study was to investigate the effectiveness of instruction supplemented by conceptual change texts (CCTs) over traditional instruction on students' understanding of electrochemical (galvanic and electrolytic) cell concepts. The participants of the study consisted of 64 students from the two classes of a high school located in Turkey. Classes were randomly assigned to experimental group, which was exposed to CCTs as a supplementary material, and to control group, which was exposed to tradi- tional instruction. A 23-item multiple-choice test was developed assess students' conceptual understanding of electrochemical cells. This test was administered to both groups before and after the instruction. The results of ANCOVA indicated that students who were instructed by using CCTs had better conceptual understanding of elec- trochemical cells than those experiencing traditional instruction when their prior electrochemical cell concepts understanding was statistically controlled. The findings of this study suggest that CCTs can be used as a cost- and resource-effective supplement to classroom instruction to promote students' understanding science concepts.
Feedback and the formation of dwarf galaxy stellar haloes

Stellar population studies show that low-mass galaxies in all environments exhibit stellar haloes that are older and more spherically distributed than the main body of the galaxy. In some cases, there is a significant intermediate age component that extends beyond the young disc. We examine a suite of Smoothed Particle Hydrodynamic simulations and find that elevated early star formation activity combined with supernova feedback can produce an extended stellar distribution that resembles these haloes for model galaxies ranging from ν 200 = 15 to 35 km s -1 , without the need for accretion of subhaloes.
Bistability in Communication Networks

Advances in the technology of modern telecommunications networks have led to considerable interest in schemes which can dynamically control the routing of calls within a network. The aim of such schemes is to adjust routing patterns within the network in accordance with varying and uncertain offered traffics, to make better use of spare capacity, and to provide extra flexibility and robustness to respond to failures or overloads. However, unless care is taken a dynamic routing strategy that appears to be beneficial may under some circumstances be detrimental. One of the simplest dynamic routing strategies is Random Alternative Routing, which operates as follows. Every call type that can arrive at the network has a fixed first choice route and a set of possible second choice routes. If possible a call will be carried on its first choice route. If not, then an alternative route is selected at random from the set of possible second choice routes. The call is carried on this route if possible and otherwise it is lost. At first sight the existence of second choice routes appears beneficial, as it gives each call more ways of being accepted. However if second choice routes require more network resource (hold more circuits or possibly hold circuits for longer) then the network performance, as measured for example by its overall loss probability, may be worse than if a call has access to just its first choice route. Further, Random Alternative Routing (and several other dynamic routing schemes) can lead to instability and hysteresis: several modes of behaviour are possible, the initial conditions of the network determining which is obtained. In this paper we use a combination of analytical, numerical and simulation approaches to investigate these phenomena, in the simplest case of a symmetric fully connected network. The possibility of bistable behaviour was first noted by Nakagome and Mori (1973), using a simple analytical fixed point approximation for the equilibrium behaviour of a network. Using a development of this approximation Krupp (1982) showed that a network’s performance could be improved by using a simple priority technique, known as trunk reservation.
Evidence-based strength and conditioning in soccer

Background . Competitive soccer is complex and acyclical in nature. In addition to the necessary technical and tactical skills, a number of well-developed physiological characteristics are required to perform successfully. Soccer is not a science, but evidence-based practice based on scientific literature can improve performance. Strength and conditioning (S&C) practitioners are now emerging as essential members of a multidisciplinary coaching team. Purpose . To review the physiological demands of soccer and provide S&C coaches with evidence-based training recommendations for elite male soccer players. Methods . To gather information on soccer match-play and effective training prescriptions, a narrative review of literature was conducted using Ovid/Medline, Pub-Med and Google Scholar data-bases. This was supplemented by a review of relevant reference lists. Results . During a 90 minute match, elite soccer players cover 10-12 km mostly by walking or jogging. High-intensity actions occur during important periods of play and are critical to the result of the match. The elite soccer player is required to complete almost 3000 actions during a match, including sprinting, jumping, turning, and decelerating. These activities are dynamic and occur in an unpredictable pattern. Conclusion . Wherever possible, S&C in soccer must replicate match-play so that specific movement patterns can be developed. Small-sided games should be manipulated to improve aerobic endurance, repeated sprint ability, and agility, while also promoting a direct transfer to the competitive environment. Strength and power sessions must prescribe varying loads to develop the full strength-power continuum. Coaches should consider the scientific evidence when implementing S&C programs in soccer.
Diagnose der präklinischen DCM: Ein praktischer Ansatz

Es ist gut dokumentiert, dass es sich bei der dilatativen Kardiomyopathie (DCM) des Hundes um eine Erkrankung handelt, die sich oft über einen Zeitraum von mehreren Jahren schrittweise im Verborgenen entwickelt, bevor klinische Symptome entstehen. Dieses symptomfreie Stadium der Erkrankung wird als präklinische Phase bezeichnet.