Miracle-dz/UniFAR-FTUs huggingface dataset:
Handover within 3GPP LTE: Design Principles and Performance

The 3GPP LTE system has been designed to offer significantly higher data rates, higher system throughput, and lower latency for delay critical services. This improved performance has to be provided and guaranteed under various mobility conditions. Hence, handover (HO) and its performance are of high importance. This paper investigates the performance of the handover procedure within 3GPP LTE in terms of HO failure rate and the delay of the whole procedure. System level simulations within a typical urban propagation environment, with different User Equipment (UE) speeds, cell radii and traffic loads per cell have been performed. The entire layer 3 signalling exchanged via air interface is considered in the simulations. In addition, errors at the Layer 1 (L1) control channels are taken into account. Simulation results show that the handover procedure within 3GPP satisfies the goal of high performance mobility. Namely for cell radii up to 1 km and for UE speeds up to 120 km/h, the HO failure rate lies within the range of 0-2.2% even in high loaded systems. For medium and low loads even at speeds of 250 km/h, HO failure is below 1.3 %. In addition, simulation results show that the handover procedure is robust against L1 control channel errors.
Gene Transfer of Connexin43 Mutants Attenuates Coupling in Cardiomyocytes: Novel Basis for Modulation of Cardiac Conduction by Gene Therapy

Modification of electrical conduction would be a useful principle to recruit in preventing or treating certain arrhythmias, notably ventricular tachycardia (VT). Here we pursue a novel gene transfer approach to modulate electrical conduction by reducing gap junctional intercellular communication (GJIC) and hence potentially modify the arrhythmia substrate. The ultimate goal is to develop a nondestructive approach to uncouple zones of slow conduction by focal gene transfer. Lentiviral vectors encoding connexin43 (Cx43) internal loop mutants were produced and studied in vitro. Transduction of neonatal rat ventricular myocytes (NRVMs) revealed the expected subcellular localization of the mutant gene product. Fluorescent dye transfer studies showed a significant reduction of GJIC in NRVMs that had been genetically modified. Additionally, adjacent mutant gene-modified NRVMs displayed delayed calcium transients, indicative of electrical uncoupling. Multi-site optical mapping of action potential (AP) propagation in gene-modified NRVM monolayers revealed a 3-fold slowing of conduction velocity (CV) relative to nontransduced NRVMs. In conclusion, lentiviral vector–mediated gene transfer of Cx43 mutants reduced GJIC in NRVMs. Electrical charge transfer was also reduced as evidenced by delayed calcium transients in adjacent NRVMs and reduced CV in NRVM monolayers. These data validate a molecular tool that opens the prospect for gene transfer targeting gap junctions as an approach to modulate cardiac conduction.
Adaptive spectral unmixing for histopathology fluorescent images

Accurate spectral unmixing of fluorescent images is clinically important because it is one of the key steps in multiplex histopathology image analysis. The narrow-band reference spectra for quantum dot biomarkers are often precisely known apriori, while the broad-band DAPI (nuclear biomarker) and tissue auto-fluorescence reference spectra are tissue dependent and vary from image to image. This paper presents a novel spectral unmixing algorithm based on data adaptive broad-band reference spectrum refinement for accurate reference spectra estimation of each image. The algorithm detects nuclear and tissue regions from the DAPI channel in the unmixed images, and estimates the new reference spectra for the biomarkers. A nuclear ranking algorithm is proposed for nuclear region segmentation to achieve more robust and accurate reference spectra estimations for the given image. The proposed framework iteratively updates the broad-band reference spectra and unmixes the fluorescent image till convergence. The algorithm was tested on a clinical data set containing a large number of multiplex fluorescent slides and demonstrates better unmixing results than the existing spectral unmixing strategies.
Modeling Post-socialist Urbanization: The Case of Budapest

Padom ‘željezne zavjese’ Istoèna je Europa ušla u razdoblje tranzicije i postsocijalizma, a s vremenom su zemlje nastale raspadom ve­ likih saveza i političkih tvorevina trasirale svoj put u kapitalizam i demokratizaciju dru­ štva. Kako su desetljeća starih režima ostavi­ la snažan peèat na kulturni milje država Var­ šavskoga pakta, svaka je zemlja pronalazila svoj način nošenja s novonastalom situaci­ jom i izazovima suvremenoga vremena, pa je tako poslijesocijalistièko razdoblje obilježe­ no brojnim varijacijama i nerijetko hibridnim sustavima razapetim između prošlosti i su­ vremenosti. U Hrvatskoj, a i u drugim zemlja­ ma nekadašnje Jugoslavije i šire, interes za reafirmaciju arhitekture bivše države posljed­ njih je godina sve naglašeniji, kako to poka­ zuje recentna izložba u MoMA-i pod nazivom Toward a Concrete Utopia: Architecture in Yugoslavia, 1948-1980, koja je dala izbor ključnih arhitekata i projekata s ovih prosto­ ra, a sličnu misiju slijedi i popularan doku­ mentarni serijal Betonski spavači koji široj publici predstavlja naše nedovoljno vrjedno­ vane realizacije druge polovice 20. stoljeća. Međutim, dok se era socijalizma kod nas (za sada) istražuje historiografski na razini poje­ dinačnih građevina ili ključnih opusa arhite­ kata toga vremena, Daniel Kiss autor knjige Modeling Post-Socialist Urbanization. The Case of Budapest upustio se u propitivanje ‘perioda nakon socijalizma’ promatrajući procese urbanizacije cijeloga grada kako bi razumio ne samo prošlost nego i recentno vrijeme kao posljedicu nekadašnjega rigid­ nog režima. Alen Žunić
Eye Movements and Orienting of Attention in Patients with Visual Neglect

The aim of the present study was to assess the relationship between overt and covert orienting of attention in visual neglect patients with parietal and fronto-parietal lesions. Two stimuli were presented at eccentricities of 8 or 20 to the left (LVF) or right (RVF) visual fields and the patient was required to maintain fixation on the central mark and to respond only manually upon the appearance of the stimulus. Neglect patients with fronto-parietal lesion showed a lack of oculomotor control and the presence of leftward eye movements without corresponding attentional shifts. Neglect patients with parietal lesions did not show this phenomenon. They rarely responded ocularly and manually to LVF stimuli, whereas they were unable to inhibit an automatic ocular orienting reaction towards RVF stimuli. When a RVF stimuli triggered both ocular and attentional shifts, the pattern of responses revealed a retinal eccentricity effect. Patients were more accurate to respond to stimuli located at 8 than 20. In contrast, when a RVF stimuli triggered only attentional shifts, the results showed the attentional gradient effect (Iiidavas, 1990). Patients were more accu- rate to respond to stimuli located at 20 than 8. Therefore, the results of the present study seem to suggest a functional dissociation of the mechanisms subserving attentional and gaze orienting and a differential role played by the frontal and parietal lobes in overt visual orienting.
Industrial drives - A view of the future

It is generally true that in order to look to the future it is essential to have a good understanding of where you are today. This paper reviews the salient features of a modern industrial drive at powers to 2 MW and voltages to 690 V, identifies the market drivers for future development and alludes to some of the more important trends.
Sc65-Null Mice Provide Evidence for a Novel Endoplasmic Reticulum Complex Regulating Collagen Lysyl Hydroxylation

Collagen is a major component of the extracellular matrix and its integrity is essential for connective tissue and organ function. The importance of proteins involved in intracellular collagen post-translational modification, folding and transport was recently highlighted from studies on recessive forms of osteogenesis imperfecta (OI). Here we describe the critical role of SC65 (Synaptonemal Complex 65, P3H4), a leprecan-family member, as part of an endoplasmic reticulum (ER) complex with prolyl 3-hydroxylase 3. This complex affects the activity of lysyl-hydroxylase 1 potentially through interactions with the enzyme and/or cyclophilin B. Loss of Sc65 in the mouse results in instability of this complex, altered collagen lysine hydroxylation and cross-linking leading to connective tissue defects that include low bone mass and skin fragility. This is the first indication of a prolyl-hydroxylase complex in the ER controlling lysyl-hydroxylase activity during collagen synthesis.
A QoS Oriented Network Service Architecture for Grid Applications

Network service support to ensure quality of service (QoS) is a key requirement for many advanced grid applications, such as collaborative working or remote visualization which require more stringent traffic guarantees. In this paper, we present a novel QoS oriented service architecture which provides network resource scheduling service in large-scale network environment based on the service level agreement (SLA) conducted between service customers and service providers. It applies the updated service-oriented and policy translation structure with excellent expansibility and efficiency in the running process. The architecture contains six components: Application Monitor Service, SLA Management, Policy management, Service management, Feedback and Network QoS Service Support. In addition, the mapping of QoS parameters using policy is discussed. At the end of the paper, an application scenario is used to validate the design methodology and demonstrate the supporting function of architecture.
Enterovirus infection and type 1 diabetes mellitus: systematic review and meta-analysis of observational molecular studies

Objective To review the association between current enterovirus infection diagnosed with molecular testing and development of autoimmunity or type 1 diabetes. Design Systematic review and meta-analysis of observational studies, analysed with random effects models. Data sources PubMed (until May 2010) and Embase (until May 2010), no language restrictions, studies in humans only; reference lists of identified articles; and contact with authors. Study eligibility criteria Cohort or case-control studies measuring enterovirus RNA or viral protein in blood, stool, or tissue of patients with pre-diabetes and diabetes, with adequate data to calculate an odds ratio and 95% confidence intervals. Results The 24 papers and two abstracts (all case-control studies) that met the eligibility criteria included 4448 participants. Study design varied greatly, with a high level of statistical heterogeneity. The two separate outcomes were diabetes related autoimmunity or type 1 diabetes. Meta-analysis showed a significant association between enterovirus infection and type 1 diabetes related autoimmunity (odds ratio 3.7, 95% confidence interval 2.1 to 6.8; heterogeneity χ2/df=1.3) and clinical type 1 diabetes (9.8, 5.5 to 17.4; χ2/df=3.2). Conclusions There is a clinically significant association between enterovirus infection, detected with molecular methods, and autoimmunity/type 1 diabetes. Larger prospective studies would be needed to establish a clear temporal relation between enterovirus infection and the development of autoimmunity and type 1 diabetes.
A study of the current spread on electric stimulation of the individual utricular and ampullary nerves.

In the cat, single vestibular nerve branches were electrically stimulated through implanted electrodes. Different combinations of extraocular muscles were activated by each of the single vestibular nerve branches, and there were three frequency-dependent contraction modes, i.e. the lateral-canal, the verticalcanal and the utricular type. It was shown that these could be utilized for detecting whether single or combined vestibular nerve branches were stimulated.
Rolling Partial Rescheduling with Dual Objectives for Single Machine Subject to Disruptions

This paper discusses the single-machine rescheduling problem with efficiency and stability as criteria, where more than one disruption arises in large-scale dynamic circumstances. Partial rescheduling (PR) strategy is adopted after each disruption and a rolling mechanism is driven by events in response to disruptions. Two kinds of objective functions are designed respectively for PR sub-problem involving in the interim and the terminal of unfinished jobs. The analytical result demonstrates that each local objective is consistent with the global one. Extensive computational experiment was performed and the computational results show that the rolling PR strategy with dual objectives can greatly improve schedule stability with little sacrifice in efficiency and provide a reasonable trade-off between solution quality and computational efforts.
Investigating and improving a COTS-based software development process

The work described in the paper is an investigation of COTS based software development within a particular NASA environment, with an emphasis on the processes used. Fifteen projects using a COTS based approach were studied and their actual process was documented. This process is evaluated to identify essential differences in comparison to traditional software development. The main differences, and the activities for which projects require more guidance, are requirements definition and COTS selection, high level design, integration and testing. Starting from these empirical observations, a new process and guidelines for COTS based development are developed and briefly presented. The new process is currently under experimentation.
Suitability of the prfA gene, which encodes a regulator of virulence genes in Listeria monocytogenes, in the identification of pathogenic Listeria spp

The pathogenesis of listerial infections is complex and involves a number of virulence factors expressed by virulent Listeria species. We have recently described a regulator gene, prfA, that positively regulates the expression of a number of virulence factors in Listeria monocytogenes. When the prfA gene was used as a DNA probe, we found it to be extremely specific for the pathogenic species L. monocytogenes. No reaction was obtained with strains of all other species of this genus. By using this information, an oligonucleotide primer pair was developed that specifically amplifies the prfA gene in L. monocytogenes strains of all known serotypes.
FELINE DYSAUTONOMIA (THE KEY‐GASKELL SYNDROME): AN ULTRA STRUCTURAL STUDY OF AUTONOMIC GANGLIA AND NERVES

Recently a feline dysautonomia of unknown aetiology, the Key‐Gaskell syndrome, has caused widespread morbidity in the UK. This report describes the ultrastructural appearances of the autonomic ganglia and axons of the sympathetic chain in this condition. Nuclei of affected neurones were eccentric and abnormally crenated. Nucleolar abnormalities such as increased electron density (due to loss of the intranucleolar vacuoles), nucleolar segregation and ring nucleoli were observed in a proportion of neurones. There was marked loss of ribosomes, both bound and unbound, and cisternae of the rough endoplasmic reticulum were distended with a floccular electron dense material. Numerous smooth‐walled cisternae were also present and complex stacks of smooth semi‐parallel membranes were observed, probably derived from the smooth endoplasmic reticulum or Golgi apparatus. No normal Golgi formations were seen. Frequent autophagic vacuoles and membranous dense bodies were present in some cells. Many unmyelinated fibres in the sympathetic chain were swollen and contained vesiculo‐tubular profiles, disordered neurotubules and filaments and various degenerating membranous organelles. Myelinated fibres within the sympathetic chain were also degenerating. These studies indicate that the organelles involved with protein biosynthesis are severely affected by the disease.
4-Block 4-phase multiplexer for MIMO-TWRC

Four multiplexer blocks are designed by four orthogonal phases and employed in Two Way Relay Channel (TWRC) network, where the nodes take advantage of two antennas. Each transmitter employs these blocks to send two independent streams. Afterwards, the relay node applies Decode-Forward (DF) relay processing to detect the streams in order to design a broadcast block. As compared with the Alamouti's single-stream blocks, the proposed new set does not experience inter-block interference and zero-block arriving. Simulation results determine new design's efficiency based on the amount of bit error rate.
Web Services Composition Optimization Based on Semi-Markov Decision Process

Web service which is a kind of component on the Internet shows good encapsulation, loosely coupled and cross-platform. However, the single Web service has inevitable limitations in functionality; it can’t provide people with more function and complex service. In order to reduce the cost and time of developing, and achieve services value-added and reuse, we need to combine existing services to form a combination of services which can satisfy user’s demand. There are a lot of services with the same functions in the process of service composition; one of the key issues is to select service by using Qos (Quality of Service). The response time is a significant factor in the process of Web service composition; it is affected by network load and service itself. It is modeled by using finite state continuous time Semi-Markov Decision Process (SMDP), and then Q learning algorithm is used to obtain the optimal service composition policy.
Production of G protein‐coupled receptors in an insect‐based cell‐free system

The biochemical analysis of human cell membrane proteins remains a challenging task due to the difficulties in producing sufficient quantities of functional protein. G protein‐coupled receptors (GPCRs) represent a main class of membrane proteins and drug targets, which are responsible for a huge number of signaling processes regulating various physiological functions in living cells. To circumvent the current bottlenecks in GPCR studies, we propose the synthesis of GPCRs in eukaryotic cell‐free systems based on extracts generated from insect (Sf21) cells. Insect cell lysates harbor the fully active translational and translocational machinery allowing posttranslational modifications, such as glycosylation and phosphorylation of de novo synthesized proteins. Here, we demonstrate the production of several GPCRs in a eukaryotic cell‐free system, performed within a short time and in a cost‐effective manner. We were able to synthesize a variety of GPCRs ranging from 40 to 133 kDa in an insect‐based cell‐free system. Moreover, we have chosen the μ opioid receptor (MOR) as a model protein to analyze the ligand binding affinities of cell‐free synthesized MOR in comparison to MOR expressed in a human cell line by “one‐point” radioligand binding experiments. Biotechnol. Bioeng. 2017;114: 2328–2338. © 2017 The Authors. Biotechnology and Bioengineering Published by Wiley Periodicals, Inc.
Is there a relation between novelty seeking, striatal dopamine release and frontal cortical thickness?

Background Novelty-seeking (NS) and impulsive personality traits have been proposed to reflect an interplay between fronto-cortical and limbic systems, including the limbic striatum (LS). Although neuroimaging studies have provided some evidence for this, most are comprised of small samples and many report surprisingly large effects given the challenges of trying to relate a snapshot of brain function or structure to an entity as complex as personality. The current work tested a priori hypotheses about associations between striatal dopamine (DA) release, cortical thickness (CT), and NS in a large sample of healthy adults. Methods Fifty-two healthy adults (45M/7F; age: 23.8±4.93) underwent two positron emission tomography scans with [11C]raclopride (specific for striatal DA D2/3 receptors) with or without amphetamine (0.3 mg/kg, p.o.). Structural magnetic resonance image scans were acquired, as were Tridimensional Personality Questionnaire data. Amphetamine-induced changes in [11C]raclopride binding potential values (ΔBPND) were examined in the limbic, sensorimotor (SMS) and associative (AST) striatum. CT measures, adjusted for whole brain volume, were extracted from the dorsolateral sensorimotor and ventromedial/limbic cortices. Results BPND values were lower in the amphetamine vs. no-drug sessions, with the largest effect in the LS. When comparing low vs. high LS ΔBPND groups (median split), higher NS2 (impulsiveness) scores were found in the high ΔBPND group. Partial correlations (age and gender as covariates) yielded a negative relation between ASTS ΔBPND and sensorimotor CT; trends for inverse associations existed between ΔBPND values in other striatal regions and frontal CT. In other words, the greater the amphetamine-induced striatal DA response, the thinner the frontal cortex. Conclusions These data expand upon previously reported associations between striatal DA release in the LS and both NS related impulsiveness and CT in the largest sample reported to date. The findings add to the plausibility of these associations while suggesting that the effects are likely weaker than has been previously proposed.
Collaborative algorithm for resource allocation in LTE-Advanced relay networks

The Capability of Relay Station deployment towards improving transmission data rates in the LTE-Advanced network has become widely accepted. However, Relay deployments are ususally burdened with the problem of resource allocation on the relay link where the relay station and users directly connected to the Donor eNB (DeNB) compete for available resources. In this paper, we propose a Collaborative Algorithm based on the Market Game theory to address this problem of Resource Allocation with LTE-Advanced Relay network. The result collated from our theoretical analysis indicates an improvement in the data rates achieved by users within the relay station's cell range.
Unobtrusive Deferred Update Stabilization for Efficient Geo-Replication

In this paper we propose a novel approach to manage the throughput vs latency tradeoff that emerges when managing updates in geo-replicated systems. Our approach consists in allowing full concurrency when processing local updates and using a deferred local serialisation procedure before shipping updates to remote datacenters. This strategy allows to implement inexpensive mechanisms to ensure system consistency requirements while avoiding intrusive effects on update operations, a major performance limitation of previous systems. We have implemented our approach as a variant of Riak KV. Our extensive evaluation shows that we outperform sequencer-based approaches by almost an order of magnitude in the maximum achievable throughput. Furthermore, unlike previous sequencer-free solutions, our approach reaches nearly optimal remote update visibility latencies without limiting throughput.