Miracle-dz/UniFAR-FTUs huggingface dataset:
A Death-associated Protein Kinase (DAPK)-interacting Protein, DIP-1, Is an E3 Ubiquitin Ligase That Promotes Tumor Necrosis Factor-induced Apoptosis and Regulates the Cellular Levels of DAPK*

Death-associated protein kinase (DAPK) is a multi-domain Ser/Thr protein kinase with an important role in apoptosis regulation. In these studies we have identified a DAPK-interacting protein called DIP-1, which is a novel multi-RING finger protein. The RING finger motifs of DIP-1 have E3 ligase activity that can auto-ubiquitinate DIP-1 in vitro. In vivo, DIP-1 is detected as a polyubiquitinated protein, suggesting that the intracellular levels of DIP-1 are regulated by the ubiquitin-proteasome system. Transient expression of DIP-1 in HeLa cells antagonizes the anti-apoptotic function of DAPK to promote a caspase-dependent apoptosis. These studies also demonstrate that DAPK is an in vitro and in vivo target for ubiquitination by DIP-1, thereby providing a mechanism by which DAPK activities can be regulated through proteasomal degradation.
A Long Term Proposal to Simulate Consciousness in Artificial Life

Computers will soon be powerful enough to simulate consciousness. The artificial life community should start to try to understand how consciousness could be simulated. The proposal is to build an artificial life system in which consciousness might be able to evolve. The idea is to develop internet-wide artificial universe in which the agents can evolve. Users play games by defining agents that form communities. The communities have to perform tasks, or compete, or whatever the specific game demands. The demands should be such that agents that are more aware of their universe are more likely to succeed. The agents reproduce and evolve within their user’s machine, but can also sometimes transfer to other machine across the internet. Users will be able to choose the capabilities of their agents from a fixed list, but may also write their own powers for their agents.
Bilingual Terminology Extraction Using Multi-level Termhood

Purpose – Terminology is the set of technical words or expressions used in specific contexts, which denotes the core concept in a formal discipline and is usually applied in the fields of machine translation, information retrieval, information extraction and text categorization, etc. Bilingual terminology extraction plays an important role in the application of bilingual dictionary compilation, bilingual ontology construction, machine translation and cross‐language information retrieval etc. This paper aims to address the issues of monolingual terminology extraction and bilingual term alignment based on multi‐level termhood.Design/methodology/approach – A method based on multi‐level termhood is proposed. The new method computes the termhood of the terminology candidate as well as the sentence that includes the terminology by the comparison of the corpus. Since terminologies and general words usually have different distribution in the corpus, termhood can also be used to constrain and enhance the performan.
Overview of the TREC-8 Web Track

The TREC-8 Web Track defined ad hoc retrieval tasks over the 100 gigabyte VLC2 collection (Large Web Task) and a selected 2 gigabyte subset known as WT2g (Small Web Task). Here, the guidelines and resources for both tasks are described and results presented and analysed. Performance on the Small Web was strongly correlated with performance on the regular TREC Ad Hoc task. Little benefit was derived from the use of link-based methods, for standard TREC measures on the WT2g collection. The number of inter-server links within WT2g may have been too small or it may be that link-based methods would have worked better with different types of query and/or with different types of relevance judgment. In fact, a small number of link-based runs proved to be much more effective than their content-only baseline at finding documents which linked to documents judged relevant. A variety of issues were investigated by participants in the Large Web Task. One group investigated the use of PageRank scores and found no benefit on standard TREC measures. Engineering improvements by several groups led to either considerable reduction in query processing time or reduction in the amount of hardware necessary to maintain comparable performance.
Multilocus Sequence Typing of Candidaglabrata Reveals Geographically EnrichedClades

ABSTRACT The haploid pathogenic yeast Candida glabrata is the second most common Candida species isolated from cases of bloodstream infection. The clinical relevance of C. glabrata is enhanced by its reduced susceptibility to fluconazole. Despite this, little is known of the epidemiology or population structure of this species. We developed a multilocus sequence typing (MLST) scheme for C. glabrata and used it to fingerprint a geographically diverse collection of 107 clinical isolates and 2 reference strains. Appropriate loci were identified by amplifying and sequencing fragments of the coding regions of 11 C. glabrata genes in 10 unrelated isolates. The 6 most variable loci (FKS, LEU2, NMT1, TRP1, UGP1, and URA3) were sequenced in the collection of 109 isolates. From the 3,345 bp sequenced in each isolate, 81 nucleotide sites were found to be variable. These defined 30 STs among the 109 strains. The technique was validated by comparison with random amplified polymorphic DNA and the complex DNA fingerprinting probes Cg6 and Cg12. MLST identified 5 major clades among the isolates studied. Three of the clades exhibited significant geographical bias. Our data demonstrate for the first time, with such a large geographically diverse strain collection, that distinct genetic clades of C. glabrata prevail in different geographical regions.
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

Summary Missense mutations in PTEN-induced kinase 1 (PINK1) cause autosomal-recessive inherited Parkinson's disease (PD). We have exploited our recent discovery that recombinant insect PINK1 is catalytically active to test whether PINK1 directly phosphorylates 15 proteins encoded by PD-associated genes as well as proteins reported to bind PINK1. We have discovered that insect PINK1 efficiently phosphorylates only one of these proteins, namely the E3 ligase Parkin. We have mapped the phosphorylation site to a highly conserved residue within the Ubl domain of Parkin at Ser65. We show that human PINK1 is specifically activated by mitochondrial membrane potential (Δψm) depolarization, enabling it to phosphorylate Parkin at Ser65. We further show that phosphorylation of Parkin at Ser65 leads to marked activation of its E3 ligase activity that is prevented by mutation of Ser65 or inactivation of PINK1. We provide evidence that once activated, PINK1 autophosphorylates at several residues, including Thr257, which is accompanied by an electrophoretic mobility band-shift. These results provide the first evidence that PINK1 is activated following Δψm depolarization and suggest that PINK1 directly phosphorylates and activates Parkin. Our findings indicate that monitoring phosphorylation of Parkin at Ser65 and/or PINK1 at Thr257 represent the first biomarkers for examining activity of the PINK1-Parkin signalling pathway in vivo. Our findings also suggest that small molecule activators of Parkin that mimic the effect of PINK1 phosphorylation may confer therapeutic benefit for PD.
Star Receiver in MIMO-CDMA Multipath Channels

This paper is concerned with the investigation of a MIMO-CDMA communication system which is based on the concept of spatiotemporal array (STAR) manifold for handling multipath fading channels. Firstly a MIMO frequency selective channel is modelled as a function of both transmitter's and receiver's antenna-array manifold vectors. Then, assuming knowledge of the channel parameters of the desired user, two linear receivers are proposed. The proposed receivers are `near-far' resistant and expressed in terms of the STAR manifold vector of the desired user. The investigation is supported by computer simulation studies where the performance of the proposed receivers is compared to the performance of conventional MMSE and RAKE receivers which have been also extended in order to be expressed in terms of the STAR manifold vectors.
The concept of classic interstitial pneumonitis-fibrosis (CIP-F) as a clinicopathologic syndrome.

The records of 81 patients with a roentgenologic pattern of diffuse reticulonodular pulmonary disease and a pathologic diagnosis of chronic interstitial pneumonitis and fibrosis were reviewed. All had restrictive patterns on pulmonary function testing with impairment of CO diffusing capacity. The most common features were characteristic dry rales, digital clubbing, and evidence of altered immune activity. Twenty patients manifested evidence of other disease thought to be of an autoimmune or hypersensitivity nature, with the pulmonary lesion dominating the clinical picture. The concept of “classic interstitial pneumonitis-fibrosis (CIP-F)” as a clinicopathologic syndrome has been proposed with the following categories: (1) definite-complete syndrome with rales, clubbing, and evidence of altered immune activity; (2) probable- rales and clubbing without evidence of altered immune activity; and (3) possible -histopathologic finding with or without evidence of altered immune activity but no rales or clubbing. Some patients progress from possible CIP-F to definite CIP-F; the latter category implies chronicity and commensurately worse prognosis.
Sequestration of Mycobacterium tuberculosis in tight vacuoles in vivo in lung macrophages of mice infected by the respiratory route

Following aerosol infection of mice with Mycobacterium tuberculosis, single mycobacteria or pairs of bacilli were observed within individual phagocytic vacuoles bound by tightly apposed vacuolar membranes. The virulent organism was not observed free in the cytoplasm of the parasitized cells or in the extracellular space of the lung granulomata. This study indicates that in vivo, virulent mycobacteria survive and probably replicate within a unique tight vacuole in the infected phagocyte within the lung.
Maternal Responses to Anticipated Children's Negative Emotions and Social Adjustment in Early Childhood

The goals of the present study were: 1) to describe and provide initial support for the validity of the Future Scenarios Questionnaire (FSQ), a new self-report questionnaire designed to measure parental responding to anticipated children’s negative emotions; and 2) to examine how maternal responses on the FSQ related to young children’s aggressive, asocial, and prosocial behaviors with peers. Further, this study examined whether the temperamental trait of negative affect moderated the relation between maternal responses on the FSQ and children’s social adjustment outcomes. Participants were 92 mothers of preschool-age children (43 boys and 49 girls; M age 61.5 months). Mothers provided ratings on the FSQ and child temperament ratings on the Child Behavior Questionnaire (CBQ; Rothbart, Ahadi, & Hershey, 1994). They also completed a range of measures which were included to assess the construct validity of the FSQ. These included measures of attachment representations, maternal mind-mindedness, perceived control, and alexithymia. Sixty-nine teachers provided ratings on the Child Behavior Scale (CBS; Ladd & Profilet, 1996) for children’s aggressive, asocial, and prosocial behaviors in the peer context.
Efficacy and Safety of Metamizol vs. Acetylsalicylic Acid in Patients With Moderate Episodic Tension-Type Headache: A Randomized, Double-Blind, Placebo- and Active-Controlled, Multicentre Study

We assessed the efficacy and safety of oral single doses of 0.5 and 1 g metamizol vs. 1 g acetylsalicylic acid (ASA) in 417 patients with moderate episodic tension-type headache included in a randomized, double-blind, placebo- and active-controlled, parallel, multicentre trial. Eligibility criteria included 18–65 years of age, history of at least two episodes of tension-type headache per month in the 3 months prior to enrolment, and successful previous pain relief with a non-opioid analgesic. Treatment arms were metamizol 0.5 g (n = 102), metamizol 1 g (n = 108), ASA 1 g (n = 102) and placebo (n = 105). The analgesic efficacy of 0.5 and 1 g metamizol vs. placebo was highly statistically significant (α: 0.025; one-sided) for sum of pain intensity differences, maximum pain intensity difference, number of patients with at least 50% pain reduction, time to 50% pain reduction, maximum pain relief and total pain relief. A trend towards an earlier onset of a more profound pain relief of 0.5 and 1 g metamizol over 1 g ASA was noticed. All medications including placebo were almost equally safe and well tolerated.
Analysis of Free Energy Signals Arising from Nucleotide Hybridization Between rRNA and mRNA Sequences during Translation in Eubacteria

A decoding algorithm is tested that mechanistically models the progressive alignments that arise as the mRNA moves past the rRNA tail during translation elongation. Each of these alignments provides an opportunity for hybridization between the single-stranded, -terminal nucleotides of the 16S rRNA and the spatially accessible window of mRNA sequence, from which a free energy value can be calculated. Using this algorithm we show that a periodic, energetic pattern of frequency 1/3 is revealed. This periodic signal exists in the majority of coding regions of eubacterial genes, but not in the non-coding regions encoding the 16S and 23S rRNAs. Signal analysis reveals that the population of coding regions of each bacterial species has a mean phase that is correlated in a statistically significant way with species () content. These results suggest that the periodic signal could function as a synchronization signal for the maintenance of reading frame and that codon usage provides a mechanism for manipulation of signal phase.
Street slide: browsing street level imagery

Systems such as Google Street View and Bing Maps Streetside enable users to virtually visit cities by navigating between immersive 360° panoramas, or bubbles. The discrete moves from bubble to bubble enabled in these systems do not provide a good visual sense of a larger aggregate such as a whole city block. Multi-perspective "strip" panoramas can provide a visual summary of a city street but lack the full realism of immersive panoramas. We present Street Slide, which combines the best aspects of the immersive nature of bubbles with the overview provided by multi-perspective strip panoramas. We demonstrate a seamless transition between bubbles and multi-perspective panoramas. We also present a dynamic construction of the panoramas which overcomes many of the limitations of previous systems. As the user slides sideways, the multi-perspective panorama is constructed and rendered dynamically to simulate either a perspective or hyper-perspective view. This provides a strong sense of parallax, which adds to the immersion. We call this form of sliding sideways while looking at a street façade a street slide. Finally we integrate annotations and a mini-map within the user interface to provide geographic information as well additional affordances for navigation. We demonstrate our Street Slide system on a series of intersecting streets in an urban setting. We report the results of a user study, which shows that visual searching is greatly enhanced with the Street Slide interface over existing systems from Google and Bing.
Relaxation Training for Psychiatric Inpatients

In Exp. 1 the effects of progressive and imaginal relaxation training were examined for 51 psychiatric inpatients. Relaxation Inventory scores indicated significant changes in the direction of greater relaxation for each training procedure; there were no significant differences in responses to the two types of training. Significant relaxation effects were found for each of three training sessions, but the effects were not cumulative. Only one patient was withdrawn because reaction to training was overtly negative. Exp. 2 was an analysis of Exp. 1 data in combination with data from a prior study. Patients and college students responded much alike but students reached greater relaxation within sessions. Further experimentation on relaxation training with psychiatric inpatients appears justified.
Experimental Validation of a Linear Array Consisting of CPW Fed, UWB, Printed, Loop Antennas

The linear array performance of an ultrawideband (UWB), coplanar waveguide (CPW) fed, printed, loop antenna is investigated by means of simulations and measurements. The UWB properties of the array are demonstrated by synthesizing the array reflection coefficient, starting from the simulated and measured scattering matrices. The array is proven to have a VSWR ¿ 2 fractional impedance bandwidth of 64%, stretching between 7 GHz and 13.6 GHz. The performance of a complete, non-scanning, broadside array are examined by feeding the array via a Wilkinson power divider. The study is completed by radiation pattern measurements that show stable co-polar and low cross-polar characteristics over the operational bandwidth.
Physiotherapy for functional motor disorders: a consensus recommendation

Background Patients with functional motor disorder (FMD) including weakness and paralysis are commonly referred to physiotherapists. There is growing evidence that physiotherapy is an effective treatment, but the existing literature has limited explanations of what physiotherapy should consist of and there are insufficient data to produce evidence-based guidelines. We aim to address this issue by presenting recommendations for physiotherapy treatment. Methods A meeting was held between physiotherapists, neurologists and neuropsychiatrists, all with extensive experience in treating FMD. A set of consensus recommendations were produced based on existing evidence and experience. Results We recommend that physiotherapy treatment is based on a biopsychosocial aetiological framework. Treatment should address illness beliefs, self-directed attention and abnormal habitual movement patterns through a process of education, movement retraining and self-management strategies within a positive and non-judgemental context. We provide specific examples of these strategies for different symptoms. Conclusions Physiotherapy has a key role in the multidisciplinary management of patients with FMD. There appear to be specific physiotherapy techniques which are useful in FMD and which are amenable to and require prospective evaluation. The processes involved in referral, treatment and discharge from physiotherapy should be considered carefully as a part of a treatment package.
Multiple Sclerosis Manifesting as Sudden Hearing Loss

We have presented a unique case in which sudden sensorineural hearing loss was the only initial symptom that developed in a patient who later displayed further symptoms consistent with multiple sclerosis. Although an uncommon cause of sudden hearing loss, multiple sclerosis should be suspected in patients whose symptoms are resistant to routine treatment modalities and in whom other (seemingly incongruous) cranial neuropathies develop.
Adaptive data-based model predictive control of batch systems

In this work, we generalize a previously developed multi-model, data-based modeling approach for batch processes to account for time-varying dynamics by incorporating online learning ability into the model. The application of the standard recursive least squares (RLS) algorithm with a forgetting factor for the model form leads to unnecessary updates for some of the models. We address this issue by developing a probabilistic RLS (PRLS) estimator (also with a forgetting factor) for each model that takes the probability of the model being representative of the current plant dynamics into account in the update. The main advantage of adopting this local update approach is adaptation tuning flexibility. Specifically, the model adaptations can be made more aggressive while maintaining better parameter precision compared to the the standard RLS algorithm. The benefits from using the PRLS algorithm for model adaptation are demonstrated via simulations of a nylon-6,6 batch polymerization reactor. The model adaptation is shown to be crucial for achieving acceptable control performance when encountering large disturbances in the initial conditions.
An Image Rotation Approach for Hand Dorsal Vein Recognition

In Biometric recognition, commonly the information about the biometric to be analyzed is contained in digital images, in particular this work is focused on analyzing hand dorsal veins as biometric. A basic process during the recognition stage is the feature (minutiae) extraction; when images are captured from several people it is very difficult to obtain a global alignment and as consequence different orientation images are obtained which makes more difficult the feature extraction. In this work we propose an approach based on central hand points for auto-rotating hand thermal images; based on the results our approach is able to rotate images from different orientations and obtains homogeneous alignment of the tested images.
A family of concatenated network codes for improved performance with generations

Random network coding can be viewed as a single block code applied to all source packets. To manage the concomitant high coding complexity, source packets can be partitioned into generations; block coding is then performed on each set. To reach a better performance-complexity tradeoff, we propose a novel concatenated network code which mixes generations while retaining the desirable properties of generation-based coding. Focusing on the code's erasure performance, we show that the probability of successfully decoding a generation on erasure channels can increase substantially for any erasure rate. Using both analysis (for small networks) and simulations (for larger networks), we show how the code's parameters can be tuned to extract best performance. As a result, the probability of failing to decode a generation is reduced by nearly one order of magnitude.
Linked USDL Agreement: Effectively Sharing Semantic Service Level Agreements on the Web

As the use of services available on the Web is becoming mainstream, contracts and legal aspects of the relationship between providers and consumers need to be formalized. However, current proposals to model service level agreements are mostly focused on technical aspects, do not explicitly provide semantics to agreement terms, and do not follow Web principles. These limitations prevent take-up, automatic processing, and effective sharing of agreements. Linked USDL Agreement is a Linked Data based semantic model to describe and share service agreements that extends Linked USDL, which offers a family of languages to describe various technical and business aspects of services. We followed a use case driven approach, evaluating the applicability of our proposal in a cloud computing scenario, and comparing its expressiveness with existing models. Finally, we show a concrete tool that helps to model and check the validity of agreements.