Miracle-dz/UniFAR-FTUs huggingface dataset:
The Mg II index for upper atmosphere modelling

The solar radio flux at 10.7 cm has been used in upper atmosphere density modelling because of its correla- tion with EUV radiation and its long and complete observa- tional record. A proxy, the Mg II index, for the solar chromo- spheric activity has been derived by Heath and Schlesinger (1986) from Nimbus-7 data. This index allows one to de- scribe the changes occurring in solar-activity in the UV Sun spectral irradiance. The use of this new proxy in upper at- mosphere density modelling will be considered. First, this is supported by the 99.9% correlation between the solar radio flux (F10.7) and the Mg II index over a period of 19 years with, however, large differences on time scales of days to months. Secondly, correlation between EUV emissions and the Mg II index has been shown recently, suggesting that this last index may also be used to describe the EUV variations. Using the same density dataset, a model was first run with the F10.7 index as a solar forcing function and second, with the Mg II index. Comparison of their respective predictions to partial density data showed a 3-8% higher precision when the modelling uses the Mg II index rather than F10.7. An ex- ternal validation, by means of orbit computation, resulted in a 20-40% smaller RMS of the tracking residuals. A density dataset spanning an entire solar cycle, together with Mg II data, is required to construct an accurate, unbiased as possi- ble density model. determination to compute the atmospheric drag force. Pre- cise satellite orbit computation, for Earth observation as in case of oceanographic satellites, also requires the estimation of many density scale factors to absorb the errors in orbit pre- dictions induced by the density model. This is only possible when a tracking system is available, with stringent require- ments concerning the accuracy, and temporal and spatial con- tinuity of its observations. A more accurate drag estimate and consequently, a more realistic density model than what is available nowadays, is required to relax this operational constraint. The reasons for the slow progress in density mod- elling since the models as early as J71 (Jacchia, 1971) are the following, though not necessarily in this order:
The diet‐derived short chain fatty acid propionate improves beta‐cell function in humans and stimulates insulin secretion from human islets in vitro

Diet‐derived short chain fatty acids (SCFAs) improve glucose homeostasis in vivo, but the role of individual SCFAs and their mechanisms of action have not been defined. This study evaluated the effects of increasing colonic delivery of the SCFA propionate on β‐cell function in humans and the direct effects of propionate on isolated human islets in vitro.
Alternative treatment for open bite Class III malocclusion in a child with Williams-Beuren syndrome

Williams-Beuren syndrome (WBS) is a rare genetic condition that affects approximately 1 in every 20,000 - 50,000 live births. WBS children have specific skeletal deformities, dental malformations and rare lingual muscle dysfunction. The need for orthodontic and orthognathic therapy has arisen and has been considered a real clinical challenge even for experienced professionals, once it requires a complex and individualized treatment plan. This study reports a case of orthopedic expansion of the maxilla, in which a modified facial mask was used for protraction of the maxillary complex associated with clockwise rotation of the maxilla. In addition, special considerations about treatment time and orthopedic outcomes are discussed.
Reliability-based optimal allocation of mirror servers for Internet

We consider the optimal mirror allocation problems for the purpose of load balance in network servers. We focus on constructing high-reliability networks, and propose the optimal mirror allocation model such that the system reliability is maximized subject to costs and delays, in view of the trading-off relationship between the reliability and cost. This optimization model is capable of dealing with various kinds of network topology. We formulate this optimization problem as a 0-1 integer programming in this model, and we can find the place where each mirror server should be and the concrete assignment of files to mirror servers. Our objective is to find the optimal mirror allocation by solving this model, and to show the general characteristics about the load balance and the improvement of the system reliability by the distributed mirror allocation, quantitatively.
Effects of WD-3 on tumor growth and the expression of integrin αvβ3 and ERK1/2 in mice bearing human gastric cancer using the 18F-RGD PET/CT imaging system

Activation of the vitronectin receptor αvβ3 and the phosphorylation of extracellular signal-regulated kinase (ERK)1/2 are critical events during tumor development and progression. The aim of the present study was to investigate the effects of WD-3, a formula used in traditional Chinese medicine, on integrin αvβ3 and ERK1/2 expression in vivo using a nude mouse-human gastric cancer xenograft model combined with non-invasive, real-time 18F-Arg-Gly-Asp (RGD) positron emission tomography (PET)/computerized tomography (CT) imaging methods. SGC-7901 human gastric cancer cells were subcutaneously injected into BALB/c nude mice. Following tumor development, animals were randomly assigned into the following 4 groups (n=6 mice/group): Control group (CG), Chinese medicine group (CMG), Western medicine group (WMG) and Chinese and Western medicine combination group (CMG + WMG). Mice in the CG and CMG received daily intragastric injections of 0.5 ml saline and 0.5 ml WD-3, respectively. Mice in the WMG received an intravenous injection of albumin-bound paclitaxel (25 mg/kg) on days 0, 2 and 4 Mice in the CMG + WMG received combination therapy of WD-3 and albumin-bound paclitaxel. Tumor growth was monitored using standard caliper technique and via PET imaging. 18F-RGD PET/CT analysis was performed on days 3, 7, 18 and 24 following drug administration. Radioactivity uptake was measured and expressed as the percentage of injected dose (ID) per tissue weight (%ID/g) and the standardized uptake value (SUV). Animals were sacrificed at 30 days following treatment and tumor weight was measured. Immunohistochemistry was used to detect the expression of phosphorylated (p)-ERK1/2 protein in tumor tissue samples. No statistically significant differences were observed in %ID/g and SUV among the various groups prior to treatment. At the end of treatment, mice in the CMG, WMG and CMG + WMG exhibited significantly reduced tumor mass when compared with mice in the CG. In addition, mice in the CMG and CMG + WMG demonstrated reduced %ID/g and SUV when compared with mice in the CG. Conversely, mice in the WMG exhibited no significant difference in %ID/g and SUV compared with the CG. Furthermore, p-ERK1/2 expression was significantly reduced in mice from all treatment groups when compared with those in the CG. The results of the present study suggest that the traditional Chinese formula WD-3 may inhibit gastric tumor growth, potentially via the downregulation of integrin αvβ3 and the inhibition of ERK1/2 phosphorylation in vivo.
A novel multiobjective generation and transmission investment framework for implementing 100% renewable energy sources

Over the last decade, it has been considerable attempts to replace thermal power plants by renewable energy sources (RESs), mainly to reduce harmful gaseous emissions. Ubiquitous nature of these sources in the emerging smart grid, demands a dominated RES power system for a long-term horizon. This study proposed a model for 100% RES-based system which is tractable and flexible enough to be used for any mixture of generation unit types with any level of uncertainty needless of the correlation between their random and unpredictable behaviours. To overcome the complex nature of RESs, an efficient stochastic multiobjective mixed-integer linear programming framework is proposed. The efficacy of the proposed model is evaluated via numerical simulation.
Electronic Nose Based on Independent Component Analysis Combined with Partial Least Squares and Artificial Neural Networks for Wine Prediction

The aim of this work is to propose an alternative way for wine classification and prediction based on an electronic nose (e-nose) combined with Independent Component Analysis (ICA) as a dimensionality reduction technique, Partial Least Squares (PLS) to predict sensorial descriptors and Artificial Neural Networks (ANNs) for classification purpose. A total of 26 wines from different regions, varieties and elaboration processes have been analyzed with an e-nose and tasted by a sensory panel. Successful results have been obtained in most cases for prediction and classification.
Sub-wavelength imaging using silver-dielectric metamaterial layered prism

In this paper we study the propagation of light through silver-dielectric metamaterial layered prism which operates in the canalization regime. The prism is illuminated with TM-polarized light and is designed using the effective medium theory as strongly anisotropic and impedance matched to air. The structure has an infinite value of the effective permittivity in the direction perpendicular to layer surfaces. Therefore it is able to couple a broad spectrum of incident spatial frequencies, including evanescent waves, into propagating modes. As a result, subwavelength resolution at the output interface of the structure is observed. Further the device is characterised with the transfer matrix method (TMM), and investigated with Finite Difference Time Domain method (FDTD). Two parameters of the prism are studied, namely the angle of incidence and the apex angle, to obtain the best resolution.
Continuous Monitoring of Vital Signs Using Wearable Devices on the General Ward: Pilot Study

Background Measurement of vital signs in hospitalized patients is necessary to assess the clinical situation of the patient. Early warning scores (EWS), such as the modified early warning score (MEWS), are generally calculated 3 times a day, but these may not capture early deterioration. A delay in diagnosing deterioration is associated with increased mortality. Continuous monitoring with wearable devices might detect clinical deterioration at an earlier stage, which allows clinicians to take corrective actions. Objective In this pilot study, the feasibility of continuous monitoring using the ViSi Mobile (VM; Sotera Wireless) and HealthPatch (HP; Vital Connect) was tested, and the experiences of patients and nurses were collected. Methods In this feasibility study, 20 patients at the internal medicine and surgical ward were monitored with VM and HP simultaneously for 2 to 3 days. Technical problems were analyzed. Vital sign measurements by nurses were taken as reference and compared with vital signs measured by both devices. Patient and nurse experiences were obtained by semistructured interviews. Results In total, 86 out of 120 MEWS measurements were used for the analysis. Vital sign measurements by VM and HP were generally consistent with nurse measurements. In 15% (N=13) and 27% (N=23) of the VM and HP cases respectively, clinically relevant differences in MEWS were found based on inconsistent respiratory rate registrations. Connection failure was recognized as a predominant VM artifact (70%). Over 50% of all HP artifacts had an unknown cause, were self-limiting, and never took longer than 1 hour. The majority of patients, relatives, and nurses were positive about VM and HP. Conclusions Both VM and HP are promising for continuously monitoring vital signs in hospitalized patients, if the frequency and duration of artifacts are reduced. The devices were well received and comfortable for most patients.
Mycoplasma genitalium testing pattern and macrolide resistance: a Danish nationwide retrospective survey.

BACKGROUND Mycoplasma genitalium is a common cause of nongonococcal urethritis (NGU) and cervicitis. The aim of the study was to analyze the M. genitalium testing pattern and distribution of positive results according to sex and age in a 5-year period where all diagnostic M. genitalium testing in Denmark was centralized at the Statens Serum Institut. A secondary aim was to estimate the occurrence of macrolide resistance in a 3-year period. METHODS The study was performed as a nationwide retrospective survey of specimens submitted from general practice, private specialists, and hospitals to Statens Serum Institut for detection of M. genitalium by polymerase chain reaction between 1 January 2006 and 31 December 2010. Macrolide resistance screening was introduced December 2007. RESULTS A total of 31 600 specimens from 28 958 patients were tested for M. genitalium, with an increasing trend from 3858 per year in 2006 to 7361 in 2010. The majority (54%) of the patients were tested in general practice. For both sexes, the positive rate increased significantly, from 2.4% to 3.8% for women and from 7.9% to 10.3% for men (P < .0005). Macrolide resistance was detected in 38% (385/1008) of the M. genitalium-positive patients, and the highest rate was found in patients tested at sexually transmitted disease clinics (43%). CONCLUSIONS Testing for M. genitalium has become important for clinicians treating sexually transmitted infections. In this nationwide survey, macrolide resistance was found in almost 40% of the specimens, raising concern about single-dose azithromycin treatment of NGU, and emphasizing that NGU treatment should be guided by etiologic diagnosis.
Medication burden of Saudi Arabian women receiving antiresorptive therapy

Background and purpose Osteoporosis is common in the Saudi Arabian population, and its successful treatment requires full compliance. Patients who require antiresorptive therapy, such as oral bisphosphonates, may suffer from other diseases requiring medications, which increases the medication burden and ends up in drug noncompliance on the part of patients, making them vulnerable to osteoporosis-related fractures. We decided to undertake this study to analyze the concomitant medications that osteoporotic patients are receiving at King Fahd Hospital of the University, Al Khobar. Methods Osteoporotic patients receiving antiresorptive therapy (ART) at King Fahd Hospital of the University, Al Khobar, were identified through the database of the QuadraMed Patient Care system and cross-checked with the radiology database of the dual-energy X-ray absorptiometry scan and pharmacy drug-dispensing system between January 2009 and December 2009. Concomitant medication is defined as the use of other drugs for ≥30 days with oral bisphosphonates, calcium, and vitamin D. Medication burdens are defined as mild (≤1 concomitant medication), moderate (≥2 and ≤4 medications), and severe (≥5 medications). The demographic data, such as age, sex, and diagnosis, were collected from the medical records. The data were analyzed using the Statistical Package for the Social Sciences (SPSS). Results During the study period, 516 patients were diagnosed with osteoporosis, and 473 were on ART while the rest were using anabolic Teriperatide. Sixty-eight (14.4%) of the patients, with an average age of 50.15 ± 2.4 years, were on one medication besides ART, vitamin D, and elemental calcium; 129 (27.3%) of the patients, with an average age of 51.6 ± 9.7 years, were taking 3.32 medications, and 276 (58.3%) of the patients, with a mean age of 62.1 ± 10.7 years, were on 8.02 concomitant medications. The most common concomitant medications in use were cardiac, endocrine, systemic nonsteroidal anti-inflammatory drugs, and analgesics, in that order. This study suggests that the majority of Saudi women who are osteoporotic and undergoing oral bisphosphonate therapy have a concomitant medication burden of ≥5 other medications. For full compliance with the therapy, the patients’ medication burden should be considered prior to selecting the treatment route.
Toward a Tiered Model to Share Clinical Trial Data and Samples in Precision Oncology

The recent revolution in science and technology applied to medical research has left in its wake a trial of biomedical data and human samples; however, its opportunities remain largely unfulfilled due to a number of legal, ethical, financial, strategic, and technical barriers. Precision oncology has been at the vanguard to leverage this potential of “Big data” and samples into meaningful solutions for patients, considering the need for new drug development approaches in this area (due to high costs, late-stage failures, and the molecular diversity of cancer). To harness the potential of the vast quantities of data and samples currently fragmented across databases and biobanks, it is critical to engage all stakeholders and share data and samples across research institutes. Here, we identified two general types of sharing strategies. First, open access models, characterized by the absence of any review panel or decision maker, and second controlled access model where some form of control is exercised by either the donor (i.e., patient), the data provider (i.e., initial organization), or an independent party. Further, we theoretically describe and provide examples of nine different strategies focused on greater sharing of patient data and material. These models provide varying levels of control, access to various data and/or samples, and different types of relationship between the donor, data provider, and data requester. We propose a tiered model to share clinical data and samples that takes into account privacy issues and respects sponsors’ legitimate interests. Its implementation would contribute to maximize the value of existing datasets, enabling unraveling the complexity of tumor biology, identify novel biomarkers, and re-direct treatment strategies better, ultimately to help patients with cancer.
Comparison between Scalp EEG and Behind-the-Ear EEG for Development of a Wearable Seizure Detection System for Patients with Focal Epilepsy

A wearable electroencephalogram (EEG) device for continuous monitoring of patients suffering from epilepsy would provide valuable information for the management of the disease. Currently no EEG setup is small and unobtrusive enough to be used in daily life. Recording behind the ear could prove to be a solution to a wearable EEG setup. This article examines the feasibility of recording epileptic EEG from behind the ear. It is achieved by comparison with scalp EEG recordings. Traditional scalp EEG and behind-the-ear EEG were simultaneously acquired from 12 patients with temporal, parietal, or occipital lobe epilepsy. Behind-the-ear EEG consisted of cross-head channels and unilateral channels. The analysis on Electrooculography (EOG) artifacts resulting from eye blinking showed that EOG artifacts were absent on cross-head channels and had significantly small amplitudes on unilateral channels. Temporal waveform and frequency content during seizures from behind-the-ear EEG visually resembled that from scalp EEG. Further, coherence analysis confirmed that behind-the-ear EEG acquired meaningful epileptic discharges similarly to scalp EEG. Moreover, automatic seizure detection based on support vector machine (SVM) showed that comparable seizure detection performance can be achieved using these two recordings. With scalp EEG, detection had a median sensitivity of 100% and a false detection rate of 1.14 per hour, while, with behind-the-ear EEG, it had a median sensitivity of 94.5% and a false detection rate of 0.52 per hour. These findings demonstrate the feasibility of detecting seizures from EEG recordings behind the ear for patients with focal epilepsy.
Clinical and Patient-Centered Outcomes in Obese Patients With Type 2 Diabetes 3 Years After Randomization to Roux-en-Y Gastric Bypass Surgery Versus Intensive Lifestyle Management: The SLIMM-T2D Study

OBJECTIVE To compare the effect of Roux-en-Y gastric bypass (RYGB) surgery versus intensive medical diabetes and weight management (IMWM) on clinical and patient-reported outcomes in obese patients with type 2 diabetes. RESEARCH DESIGN AND METHODS We prospectively randomized 38 obese patients with type 2 diabetes (15 male and 23 female, with mean ± SD weight 104 ± 16 kg, BMI 36.3 ± 3.4 kg/m2, age 52 ± 6 years, and HbA1c 8.5 ± 1.3% [69 ± 14 mmol/mol]) to laparoscopic RYGB (n = 19) or IMWM (n = 19). Changes in weight, HbA1c, cardiovascular risk factors (UKPDS risk engine), and self-reported health status (the 36-Item Short-Form [SF-36] survey, Impact of Weight on Quality of Life [IWQOL] instrument, and Problem Areas in Diabetes Survey [PAID]) were assessed. RESULTS After 3 years, the RYGB group had greater weight loss (mean −24.9 kg [95% CI −29.5, −20.4] vs. −5.2 [−10.3, −0.2]; P < 0.001) and lowering of HbA1c (−1.79% [−2.38, −1.20] vs. −0.39% [−1.06, 0.28] [−19.6 mmol/mol {95% CI −26.0, −13.1} vs. −4.3 {−11.6, 3.1}]; P < 0.001) compared with the IMWM group. Changes in cardiometabolic risk for coronary heart disease and stroke were all more favorable in RYGB versus IMWM (P < 0.05 to P < 0.01). IWQOL improved more after RYGB (P < 0.001), primarily due to subscales of physical function, self-esteem, and work performance. SF-36 and PAID scores improved in both groups, with no difference between treatments. A structural equation model demonstrated that improvement in overall quality of life was more strongly associated with weight loss than with improved HbA1c and was manifest by greater improvements in IWQOL than with either SF-36 or PAID. CONCLUSIONS Three years after randomization to RYGB versus IMWM, surgery produced greater weight loss, lower HbA1c, reduced cardiovascular risk, and improvements in obesity-related quality of life in obese patients with type 2 diabetes.
From Chemotherapy to Combined Targeted Therapeutics: In Vitro and in Vivo Models to Decipher Intra-tumor Heterogeneity

Recent advances in next-generation sequencing and other omics technologies capable to map cell fate provide increasing evidence on the crucial role of intra-tumor heterogeneity (ITH) for cancer progression. The different facets of ITH, from genomic to microenvironmental heterogeneity and the hierarchical cellular architecture originating from the cancer stem cell compartment, contribute to the range of tumor phenotypes. Decoding these complex data resulting from the analysis of tumor tissue complexity poses a challenge for developing novel therapeutic strategies that can counteract tumor evolution and cellular plasticity. To achieve this aim, the development of in vitro and in vivo cancer models that resemble the complexity of ITH is crucial in understanding the interplay of cells and their (micro)environment and, consequently, in testing the efficacy of new targeted treatments and novel strategies of tailoring combinations of treatments to the individual composition of the tumor. This challenging approach may be an important cornerstone in overcoming the development of pharmaco-resistances during multiple lines of treatment. In this paper, we report the latest advances in patient-derived 3D (PD3D) cell cultures and patient-derived tumor xenografts (PDX) as in vitro and in vivo models that can retain the genetic and phenotypic heterogeneity of the tumor tissue.