Miracle-dz/UniFAR-FTUs huggingface dataset:
Relation of insulin resistance to blood pressure in childhood

Objective To determine the relation between blood pressure and insulin resistance in children and the differences between fasting insulin and the insulin clamp in that relation. Methods Children were randomly selected after blood pressure screening of 12 043 fifth–eigth grade Minneapolis, Minnesota, students, with stratification by systolic blood pressure (SBP) percentile [half from the upper 25th percentile (high blood pressure) and half from the lower 75th percentile (low blood pressure)]. Euglycemic insulin clamps were performed with an insulin infusion rate of 1 mU/kg per min and a variable infusion of 20% glucose to maintain plasma glucose at 5.6 mmol/l (100 mg/dl). Insulin sensitivity (Mlbm) is defined as the amount of glucose required to maintain euglycemia (mg glucose infused/kg lean body mass (LBM)/min. Results Diastolic blood pressure was not significantly correlated with any of the body measurements or laboratory data. SBP was significantly correlated with virtually all measures of body size in males and females. SBP and Mlbm were not significantly correlated in either sex. The correlation between SBP and fasting insulin was significant for boys and girls, but became non-significant after adjustment for BMI. All measures of body fatness were significantly greater in the high blood pressure group, and a significant clustering effect for fasting insulin, BMI, triglycerides, and HDL-C was related to blood pressure. The clustering effect was similar when Mlbm was substituted for fasting insulin and was similar for boys, girls, blacks and whites. Conclusions These results suggest that level of blood pressure in children is mediated through body fat and that insulin resistance, as determined by the insulin clamp, does not play a primary role at this age of development. Nevertheless, the clustering effect of the risk factors according to SBP grouping is consistent with an early relation of blood pressure to the insulin resistance syndrome.
Using technology to prevent adverse drug events in the intensive care unit

Critically ill patients are particularly susceptible to adverse drug events (ADEs) due to their rapidly changing and unstable physiology, complex therapeutic regimens, and large percentage of medications administered intravenously. There are a wide variety of technologies that can help prevent the points of failure commonly associated with ADEs (i.e., the five “Rights”: right patient; right drug; right route; right dose; right frequency). These technologies are often categorized by their degree of complexity to design and engineer and the type of error they are designed to prevent. Focusing solely on the software and hardware design of technology may over- or underestimate the degree of difficulty to avoid ADEs at the bedside. Alternatively, we propose categorizing technological solutions by identifying the factors essential for success. The two major critical success factors are: 1) the degree of clinical assessment required by the clinician to appropriately evaluate and disposition the issue identified by a technology; and 2) the complexity associated with effective implementation. This classification provides a way of determining how ADE-preventing technologies in the intensive care unit can be successfully integrated into clinical practice. Although there are limited data on the effectiveness of many technologies in reducing ADEs, we will review the technologies currently available in the intensive care unit environment. We will also discuss critical success factors for implementation, common errors made during implementation, and the potential errors using these systems.
The overlap between personality disorders and major depressive disorder (MDD).

BACKGROUND Research studies have focused attention on the importance of the comorbidity of personality disorders and depression. METHODS The present review examines seven potential explanations for the overlap to clarify the nature of the relationship, if any, between depression and personality disorder diagnoses. RESULTS There may be many explanations for the potential overlap of personality disorders (PD) and major depressive disorder (MDD). For example, the distinction between states and traits may not be as clear and definitive as suggested in the DSM-IV. In some cases, depression may influence personality pathology, and may even lead to personality disorders. In other cases, personality disorders may lead to MDD. CONCLUSION Further research may clarify the nature of the relationship, if any, between depression and personality disorder diagnoses, as well as the relationship between comorbidity and treatment response.
Catching a red herring: autumn colours and aphids

The purpose of this note is not to support any particular hypothesis explaining the evolution of red coloured autumn leaves, but to present evidence that shows existing knowledge does not support one such hypothesis - that red coloured leaves evolved as a signal to protect trees from aphids feeding and laying eggs on them in autumn. An alternative hypothesis is that autumn-feeding aphids are senescence-feeders, evolved to feed only on senescing leaves. These aphids are programmed to detect and feed on such leaves when they are still green and yellow and actively exporting their nutrients. Aphids reject or ignore red leaves because they are no longer good food, not because they are protecting the trees from the aphids.
COMS: Customer Oriented Migration Service

Virtual machine live migration has been studied for more than a decade, and this technique has been implemented in various commercial hypervisors. However, currently in the cloud environment, virtual machine migration is initiated by system administrators. Cloud customers have no say on this: They can not initiate a migration, and they do not even know whether or not their virtual machines have been migrated. In this paper, we propose the COMS framework, which is short for "Customer Oriented Migration Service". COMS gives more control to cloud customers so that migration becomes a service option and customers are more aware of the migration process. We have implemented a suite of modules in our COMS framework. Our evaluation results show that these modules could either bring performance benefit to cloud customers, or mitigate security threats in the cloud environment.
Experimental evidence of invasion facilitation in the zebra mussel-killer shrimp system

Invasion facilitation, whereby one species has a positive effect on the establishment of another species, could help explain the rapid colonisation shown by some freshwater invasive species, but the underlying mechanisms remain unclear. We employed two-choice test arenas to test whether the presence of zebra mussel (Dreissena polymorpha) could facilitate the establishment of the killer shrimp (Dikerogammarus villosus). Killer shrimp preferred to settle on mats of zebra mussel, but this was unrelated to mat size, and was not different from attraction shown to artificial grass, suggesting that zebra mussel primarily provides substrate and refuge to the killer shrimp. Killer shrimp were strongly attracted to water scented by zebra mussel, but not to water scented by fish. Chemical attraction to the zebra mussel’s scent did not differ between sympatric and allopatric populations of killer shrimp, suggesting that chemical facilitation is not an acquired or learned trait. Our results have implications for managing the spread of killer shrimp, and perhaps other freshwater invasive species, because invasion facilitation could significantly increase establishment success. Failure to consider invasion facilitation may underestimate the risk of establishment and likely impact of some aquatic invaders.
Unusual sonographic finding in a patient with late recurrence of a perianal fistula

We describe a case of late recurrence of a perianal fistula in a 51‐year‐old man with a 4.5‐year history of recurrent perianal fistulas and abscesses. This was the fourth recurrence he had experienced; at each occurrence, he had undergone various examinations, including sigmoidoscopy, anoscopy, barium enema, fistulography, probe exploration, instillation of hydrogen peroxide, and/or sonography, and he had also undergone surgery. At our examination, transperineal sonography with a portable ultrasound scanner revealed an echogenic linear structure within the fistulous tract. Under endoanal sonographic guidance, surgery was performed, and a tan solid cylindrical structure longer than 2 cm was removed. Histopathologic examination revealed stratified squamous epithelium and soft tissue with substantial fibrosis and mild chronic inflammation, findings consistent with the characteristics of a remnant cast from a previous fistulous tract. Our findings suggest that some patients may benefit from relatively inexpensive sonographic examination with appropriate transducers. © 2002 Wiley Periodicals, Inc. J Clin Ultrasound 30: 557–561, 2002; Published online in Wiley InterScience (www.interscience.wiley.com). DOI: 10.1002/jcu.10113
Essays on the Effectiveness and Competitiveness of State Government Expenditures

Essays on the Effectiveness and Competitiveness of State Government Expenditures J. Sebastian Leguizamon This dissertation addresses issues related to the effectiveness and consequences of state and local spending in the United States. Chapter two examines how merit-based aid tuition assistance contributes to the retention of graduates in a state. An analysis of restricteduse administrative data for West Virginia graduates suggests that in-state college graduates that received merit-based aid to attend college are no more likely to work in the state after graduation, compared to those who did not received the assistance. These graduates are between 1.9 and 5.2 percentage points less likely to remain in the state, decreasing the overall effect of merit-based assistance on the retention of human capital. In chapter three I calculate the implicit marginal tax rates for individuals that participate in multiple welfare programs and use them to examine the extent to which it may affect labor force participation of welfare recipients after the reform of 1996. The analysis supports the hypothesis that high implicit marginal tax rates discourages workers from looking for work and becoming self-sufficient. On average, a standard-deviation increase in these rates lowers the work participation rates of TANF recipients by 0.208 standard deviations, or 8.5 percent. Chapter four looks at the consequences of state welfare spending across the border. In it, I use data from 1987 to 2007 and find that the interaction of state governments does depend on the political environment of each state. Single party majority governments do not react to neighboring states’ welfare spending while divided governments do. Also, fiscal policy reactions among states appear to depend on what political party holds the majority. Finally, the analysis suggests that the welfare reform of 1996 did change the way in which these governments reacted to one another, which can be mainly attributed to the change from a matching-grant to a blockgrant system. An initial examination of the data suggests that the surge in Republican elected officials after the reform may have also played a role in the way state governments interact.
In vitro activity of HSR-903, a new quinolone

The in vitro activity of the new fluoroquinolone HSR-903 was compared with those of ciprofloxacin, lomefloxacin, sparfloxacin, and levofloxacin. HSR-903 inhibited 90% of methicillin-susceptible and -resistant Staphylococcus aureus (MRSA) clinical isolates at 0.78 and 1.56 microg/ml, respectively, and its activity against MRSA was 16-fold higher than those of sparfloxacin and levofloxacin and 64-fold higher than that of ciprofloxacin. The MICs at which 90% of the isolates are inhibited (MIC90s) of HSR-903 for Streptococcus pyogenes and penicillin G-susceptible and -resistant Streptococcus pneumoniae (PRSP) were 0.10, 0.05, and 0.05 microg/ml, respectively. Against PRSP, the activity of HSR-903 was 4-fold higher than that of sparfloxacin and 32- to 256-fold higher than those of the other quinolones. The MIC90 of HSR-903 for Enterococcus faecalis was 0.20 microg/ml, and HSR-903 was more active than the other quinolones against enterococci. The activity of HSR-903 against members of the family Enterobacteriaceae and Pseudomonas aeruginosa was roughly similar to that of ciprofloxacin and greater than those of the other quinolones. Against Haemophilus influenzae, Moraxella catarrhalis, and Helicobacter pylori, HSR-903 was the most potent of the quinolones tested. The activity of HSR-903 was not affected by the medium, the inoculum size, or the addition of serum, but decreased under acidic conditions, as did those of the other quinolones tested. HSR-903 exhibited rapid bactericidal action and had a good postantibiotic effect on S. aureus and P. aeruginosa. HSR-903 inhibited supercoiling by DNA gyrase from Escherichia coli, but it was much less active against human topoisomerase II.
Import Exposure and Human Capital Adjustment: Evidence from the U.S.

We exploit variation in exposure to Chinese import competition to identify the effect of trade-induced changes in labor market conditions on human capital accumulation in the U.S. from 1990 to 2007. We document large increases in U.S. high school graduation rates in the labor markets most affected by import competition. After controlling for established predictors of high school completion, demographic shifts, and coincident labor market changes unrelated to trade with China, we estimate that a movement from the 25th to the 75th percentile in Chinese import exposure led to an average increase in the graduation rate of 3.64 percentage points. Consistent with an environment in which students weigh increases in future earnings potential from further education against current labor market opportunities foregone, we find that growth in Chinese imports led to declines in wages for all educational groups, and reductions in employment for individuals without a high school degree both in absolute terms and relative to their more educated peers.
Primary Immunodeficiency Disorders in India—A Situational Review

Primary immunodeficiency disorders (PIDs) are a group of genetic defects characterized by abnormalities of one or more components of the immune system. While there have been several advances in diagnosis, management, and research in the field of PIDs, they continue to remain underdiagnosed, especially in the less affluent countries. Despite several limitations and challenges, India has advanced significantly in the field of PIDs in the last few years. In this review, we highlight the progress in the field of PIDs in India over the last 25 years, the difficulties faced by clinicians across the country, the current state of PIDs in India and the future prospects.
The Mechanisms that Determine the Response of the Northern Hemisphere’s Stationary Waves to North American Ice Sheets

Stationary waves describe the persistent meanders in the west–east flow of the extratropical atmosphere. Here, changes in stationary waves caused by ice sheets over North America are examined and the underlying mechanisms are discussed. Three experiment sets are presented showing the stationary wave response to the albedo or topography of ice sheets, as well as the albedo and topography in combination, as the forcings evolve from 21 to 6 ka. It is found that although the wintertime stationary waves have the largest amplitude, changes due to an ice sheet are equally large in summer and winter. In summer, ice sheet albedo is the dominant cause of changes: topography alone gives an opposite response to realistic ice sheets including albedo and topography. In winter, over the Atlantic, stationary wave changes are due to the ice sheet topography; over the Pacific, they are due to the persistence of summertime changes, mediated by changes in the ocean circulation. It is found that the response of stationary waves over the last deglaciation echoes the above conclusions, with no evidence of abrupt shifts in atmospheric circulation. The response linearly weakens as the albedo and height decrease from 21 to 10 ka. As potential applications, the seasonal cycle over Greenland is shown to be sensitive primarily to changes in summer climate caused by the stationary waves; the annual mean circulation over the North Pacific is found to result from summertime, albedo-forced, stationary wave effects persisting throughout the year because of ocean dynamics.
The determinants of inbound tourism to Malaysia: a panel data analysis

Malaysia has experienced a significant increase in tourist arrivals over the past 10 years. The challenge is to sustain this growth and therefore it is important to understand the factors influencing inbound tourism to Malaysia. This paper investigates the economic and non-economic determinants of international tourist flows to Malaysia using the generalized method of moment. The annual panel data set includes the number of arrivals from 33 countries during the period 2000–2012, and the number of possible explanatory variables. It is found that habit persistence (word of mouth), income, hotel room and political stability have a positive impact on tourism demand for Malaysia. Also, results indicate that the estimated coefficients of substitute tourism price in the model are negative. This implies that the five alternative destinations are complementary destinations to Malaysia. In addition, the dummy variable for Visit Malaysia Year in 2007 and severe acute respiratory syndrome in 2003 had positive and negative impacts on tourism demand for Malaysia, respectively.
Contributions of observational evidence and clinical trials in cancer prevention

Observational studies and randomized trials provide relevant and complementary information to a totality of evidence on which to base rational clinical decision making for patients and overall health policy for the general population. Observational studies are particularly useful for detecting moderate to large effects. The 15‐ to 20‐fold greater risk of lung cancer among long term cigarette smokers was established by case‐control and prospective cohort studies. The approximate 80% increased risk of coronary heart disease associated with current smoking also has been reliably demonstrated in observational studies. However, as the relative risk gets smaller, there is increasing concern that unmeasured or unknown confounding variables may account for all or part of any observed association. For these reasons, reliable inferences about interventions likely to confer small to moderate benefits will emerge only from randomized trials of sufficient sample size and duration of treatment and follow‐up. Dietary variables have been postulated to account for as much as 35% of all human cancers. However, the hypothesized benefit of any specific dietary constituent, such as the antioxidant beta‐carotene, is likely to be modest in size, on the order of a 20–30% reduction in risk. Therefore, although a large number of observational studies have demonstrated that individuals with higher dietary intakes or blood levels of beta‐carotene have lower risks of cancer, only randomized trials can address this hypothesis definitively. Such trials, however, must be of sufficient duration to allow for the development of an anticancer effect. This may mean a decade or more based on the analogy with smoking cessation and decreased risks of lung cancer. Several ongoing large‐scale trials are testing beta‐carotene and other promising cancer chemoprevention agents, and their results will provide clear evidence on the balance of benefits and risks of these interventions.
Family cohesion and flexibility in early episode psychosis

Research suggests that family support promotes recovery and is a key component of a successful early intervention programme. However, very little is known about family functioning in families that are coping with the onset of a psychotic illness and the factors that help to foster adaptive family functioning during this challenging time. The purpose of this study was to understand the individual, caregiver and family factors that are associated with adaptive family functioning in early episode psychosis.
The Opportunistic Pathogen Toxoplasma gondii Deploys a Diverse Legion of Invasion and Survival Proteins*

Host cell invasion is an essential step during infection by Toxoplasma gondii, an intracellular protozoan that causes the severe opportunistic disease toxoplasmosis in humans. Recent evidence strongly suggests that proteins discharged from Toxoplasma apical secretory organelles (micronemes, dense granules, and rhoptries) play key roles in host cell invasion and survival during infection. However, to date, only a limited number of secretory proteins have been discovered, and the full spectrum of effector molecules involved in parasite invasion and survival remains unknown. To address these issues, we analyzed a large cohort of freely released Toxoplasma secretory proteins by using two complementary methodologies, two-dimensional electrophoresis/mass spectrometry and liquid chromatography/electrospray ionization-tandem mass spectrometry (MudPIT, shotgun proteomics). Visualization of Toxoplasma secretory products by two-dimensional electrophoresis revealed ∼100 spots, most of which were successfully identified by protein microsequencing or matrix-assisted laser desorption ionization-mass spectrometry analysis. Many proteins were present in multiple species suggesting they are subjected to substantial post-translational modification. Shotgun proteomic analysis of the secretory fraction revealed several additional products, including novel putative adhesive proteins, proteases, and hypothetical secretory proteins similar to products expressed by other related parasites including Plasmodium, the etiologic agent of malaria. A subset of novel proteins were re-expressed as fusions to yellow fluorescent protein, and this initial screen revealed shared and distinct localizations within secretory compartments of T. gondii tachyzoites. These findings provided a uniquely broad view of Toxoplasma secretory proteins that participate in parasite survival and pathogenesis during infection.