Miracle-dz/UniFAR-FTUs huggingface dataset:
The olive DGAT2 gene is developmentally regulated and shares overlapping but distinct expression patterns with DGAT1

Diacylglycerol acyltransferases (DGATs) catalyse the final step of the triacylglycerol (TAG) biosynthesis of the Kennedy pathway. Two major gene families have been shown to encode DGATs, DGAT1 (type-1) and DGAT2 (type-2). Both genes encode membrane-bound proteins, with no sequence homology to each other. In this study, the molecular cloning and characterization of a type-2 DGAT cDNA from olive is presented. Southern blot analysis showed that OeDGAT2 is represented by a single copy in the olive genome. Comparative transcriptional analysis revealed that DGAT1 and DGAT2 are developmentally regulated and share an overall overlapping but distinct transcription pattern in various tissues during vegetative growth. DGAT2 is highly expressed in mature or senescing olive tissues. In flowers, the expression of DGAT1 was almost undetectable, while DGAT2 transcripts accumulated at the later stages of both anther and ovary development. Differential gene regulation was also detected in the seed and mesocarp, two drupe compartments that largely differ in their functional roles and mode of lipid accumulation. DGAT1 appears to contribute for most of the TAG deposition in seeds, whereas, in the mesocarp, both DGAT1 and DGAT2 share an overlapping expression pattern. During the last stages of mesocarp growth, when TAGs are still accumulating, strong up-regulation of DGAT2 but a marked decline of DGAT1 transcript levels were detected. The present results show overlapping gene expression for olive DGATs during mesocarp growth, with a more prominent implication of DGAT2 in floral bud development and fruit ripening.
Failure, Disconnection and Partition Detection in Mobile Environment

In mobile environment, nodes can move around and voluntarily leave or join the network. Furthermore, they can crash or be disconnected from the network due to the absence of network signals. Therefore, failure, disconnection and mobility may create partitions in wireless networks which should be detected for fault and disconnection tolerance reasons. We present in this article an architecture of local and distributed detectors for mobile networks that detect failures, disconnections, and partitions. It is basically composed of three unreliable detectors: a heartbeat failure detector, a vector-based disconnection detector, and an eventually perfect partition detector.
V. Multi-Level Analysis of Cortical Neuroanatomy in Williams Syndrome

The purpose of a neuroanatomical analysis of Williams Syndrome (WMS) brains is to help bridge the knowledge of the genetics of this disorder with the knowledge on behavior. Here, we outline findings of cortical neuroanatomy at multiple levels. We describe the gross anatomy with respect to brain shape, cortical folding, and asymmetry. This, as with most neuroanatomical information available in the literature on anatomical-functional correlations, links up best to the behavioral profile. Then, we describe the cytoarchitectonic appearance of the cortex. Further, we report on some histometric results. Finally, we present findings of immunocy-tochemistry that attempt to link up to the genomic deletion. The gross anatomical findings consist mainly of a small brain that shows curtailment in the posterior-parietal and occipital regions. There is also subtle dysmorphism of cortical folding. A consistent finding is a short central sulcus that does not become opercularized in the interhemispheric fissure, bringing attention to a possible developmental anomaly affecting the dorsal half of the hemispheres. There is also lack of asymmetry in the planum temporale. The cortical cytoarchitecture is relatively normal, with all sampled areas showing features typical of the region from which they are taken. Measurements in area 17 show increased cell size and decreased cell-packing density, which address the issue of possible abnormal connectivity. Immunostaining shows absence of elastin but normal staining for Lim-1 kinase, both of which are products of genes that are part of the deletion. Finally, one serially sectioned brain shows a fair amount of acquired pathology of microvascular origin related most likely to underlying hypertension and heart disease.
‘Opening for business’? Neoliberalism and the cultural politics of modernising planning in Scotland

In this paper I explore how the culture of land-use planning in Scotland has been targeted as an object of modernising reform, exploring how ‘culture change’ initiatives played a prominent role in stabilising a new settlement around ‘open for business’ planning between 2006 and 2012, containing potential tensions between diverse goals to make planning more efficient, inclusive and integrative. This highlights the potentially significant role of governance cultures in containing tensions and securing consent to processes of state restructuring. I therefore argue that greater empirical attentiveness to the cultural micro-politics of state restructuring can improve understanding of complex, contemporary dynamics of change, and the contested role of the neoliberal hegemonic project in reshaping urban governance. I conclude by arguing that the continued power of neoliberal critiques of the inefficiency of land-use planning indicate a need to acknowledge and engage contemporary cultural battles over the purposes of planning and urban governance.
Utility-driven evolution recommender for a constrained ontology

Ontology evolution continues to be an important problem that needs further research. Key challenges in ontology evolution and creation of a highly consumable ontology include accomodating: (a) the subtle changes in the meaning of a model element over time, (b) the changing relevance of various parts of the model to the user, and (c) the complexity in representing time-varying semantics of model elements in a dynamic domain. In this work, we address the challenge of evolving an ontology to keep up with the domain changes while focusing on the utility of its content for relevance and imposing constraints for performance. We propose a novel evidence accumulation framework as a principled approach for ontology evolution, which is sufficiently expressive and semantically clear. Our approach classifies model elements (e.g., concepts) into three categories: definitely relevant (that must be included in the ontology), potentially relevant (that can be kept as backup), and irrelevant (that should be removed). Further, our approach dynamically re-classifies models based on external triggers like evidence or internal triggers, like the age of a model in the ontology. As a result, users will have an ontology which is both effective and efficient. We evaluate our approach based on two measures - ontology concept retention and ontology concept placement. This comprehensive evaluation in a single framework is novel and we show that our approach yields promising results.
Linear Quadratic Gaussian Controller Design Using a Graphical User Interface: Application to the Beam-Waveguide Antennas

The linear quadratic Gaussian (LQG) design algorithms described in [2] and [5] have been used in the controller design of JPL’s beam-waveguide [5] and 70-m [6] antennas. This algorithm signiflcantly improves tracking precision in a windy environment. This article describes the graphical user interface (GUI) software for the design LQG controllers. It consists of two parts: the basic LQG design and the flne-tuning of the basic design using a constrained optimization algorithm. The presented GUI was developed to simplify the design process, to make the design process user-friendly, and to enable design of an LQG controller for one with a limited control engineering background. The user is asked to manipulate the GUI sliders and radio buttons to watch the antenna performance. Simple rules are given at the GUI display. I. Introduction The linear quadratic Gaussian (LQG) controllers, as designed for the beam-waveguide (BWG) antennas, show signiflcantly improved performance over the ones initially implemented. However, the design of the LQG controllers for the BWG antennas is an iterative process that requires some experience in controller design. In order to make the process of the controller design simple and user-friendly, a controller design graphical user interface (GUI) was developed. This article describes the Matlab-based software that allows for the basic design and flne-tuning of the antenna LQG controllers. The approach is based on the algorithm described in [2] and [5], which was coded in Matlab and used in the LQG controller design of the BWG [5] and 70-m antennas [6]. The GUI presented here was developed to simplify the design process and to create a user-friendly environment in which one with a limited control engineering background may design an LQG controller.
Differential Alterations in the Expression of Neurotransmitter Receptors in Inner Retina following Loss of Photoreceptors in rd1 Mouse

Loss of photoreceptors leads to significant remodeling in inner retina of rd1 mouse, a widely used model of retinal degeneration. Several morphological and physiological alterations occur in the second- and third-order retinal neurons. Synaptic activity in the excitatory bipolar cells and the predominantly inhibitory amacrine cells is enhanced. Retinal ganglion cells (RGCs) exhibit hyperactivity and aberrant spiking pattern, which adversely affects the quality of signals they can carry to the brain. To further understand the pathophysiology of retinal degeneration, and how it may lead to aberrant spiking in RGCs, we asked how loss of photoreceptors affects some of the neurotransmitter receptors in rd1 mouse. Using Western blotting, we measured the levels of several neurotransmitter receptors in adult rd1 mouse retina. We found significantly higher levels of AMPA, glycine and GABAa receptors, but lower levels of GABAc receptors in rd1 mouse than in wild-type. Since GABAa receptor is expressed in several retinal layers, we employed quantitative immunohistochemistry to measure GABAa receptor levels in specific retinal layers. We found that the levels of GABAa receptors in inner plexiform layer of wild-type and rd1 mice were similar, whereas those in outer plexiform layer and inner nuclear layer combined were higher in rd1 mouse. Specifically, we found that the number of GABAa-immunoreactive somas in the inner nuclear layer of rd1 mouse retina was significantly higher than in wild-type. These findings provide further insights into neurochemical remodeling in the inner retina of rd1 mouse, and how it might lead to oscillatory activity in RGCs.
Performance Analysis of Multilayered Multipriority Asymmetric-Sized Delta Networks

The performance of multilayered asymmetric-sized finite-buffered delta networks supporting multiclass routing traffic is presented and analyzed in the uniform traffic conditions under various loads using simulations. The rationale behind introducing asymmetric-sized buffered systems is to have a better exploitation of available buffer spaces, while the implementation of multilayered architecture is applied in order to further improve the overall performance of network. The findings of this performance evaluation can be used by network designers for drawing optimal configurations while setting up the network, so as to best meet the performance and cost requirements under the anticipated traffic load and quality of service specifications.
The Effect of a Lactobacillus-Based Probiotic for the Control of Necrotic Enteritis in Broilers

Necrotic Enteritis (NE) caused by Clostridium perfringens (CP) in poultry is probably the most important bacterial disease in terms of economic implications. The disease is multi-factorial and is invariably associated with predisposing factors. The present study investigated the effect of a commercially available Lactobacillus-based probiotic (FM-B11) for the control of necrotic enteritis in broiler chickens. In experiment 1, one-day-of-hatch broiler chicks were randomly allocated to the following treatment groups: 1) Non-challenged (NC); 2) Challenged (C); 3) Challenged + probiotic (C+ FM-B11). Prior to placement, chicks in groups 2 and 3 received 0.25 mL of Salmonella typhimurium (ST) containing 10 5 cfu of viable cells by oral gavage. At 14, 15 and 16 days of age, all chicks in group 3 were treated with FM-B11 in the drinking water at a concentration of 10 6 cfu/ml. At 21d of age, all chicks in groups 2 and 3, were individually challenged with 5 × 10 4 sporulated oocysts of E. maxima by oral gavage. At 26d of age, all chicks in groups 2 and 3, were individually challenged with 10 8 cfu CP; body weight (BW) was recorded prior to challenge. The experiment was terminated at 29 days of age and the following parameters were evaluated: NE-associated mortality, CP lesion scores, CP concentrations in ileum, BW, and body weight gain (BWG). Chicks treated with FM-B11 had significantly (P 0.05) difference in lesion score between C and C + FM-B11, group C + FM-B11 had significantly (P < 0.05) lower total number of cfu of CP recovered from the ileal mucosa and content samples when compared to group C. Experiment 2 was a unique and remarkable case report of a field outbreak of NE in a commercial broiler farm in Argentina. A reduction and control of the mortality associated with NE following 3 days of administration of FM-B11 was observed as compared with the control non treated house. These results imply that the commercially available Lactobacillus-based probiotic FM-B11 was able to reduce the severities of NE, as a secondary bacterial infection, in an experimental NE challenge model; as well as, in a commercial field outbreak of NE.
Considering complex search techniques in DHTs under churn

Traditionally complex queries have been performed over unstructured P2P networks by means of flooding, which is inherently inefficient due to the large number of redundant messages generated. While Distributed Hash Tables (DHTs) can provide very efficient look-up operations, they traditionally do not provide any methods for complex queries. By exploiting the structure inherent in DHTs we can perform complex querying over structured P2P networks by means of efficiently broadcasting the search query. This allows every node in the network to process the query locally, and hence is as powerful and flexible as flooding in unstructured networks, but without the inefficiency of redundant messages. While there have been various approaches proposed for broadcasting search queries over DHTs, the focus has not been on validation under churn. Comparing blind search methods for DHTs though simulation we see that churn, in particular nodes leaving the network, has a large impact on query success rate. In this paper we present novel results comparing blind search over Chord and Pastry while under varying levels of churn. We further consider how different data replication strategies can be used to enhance the query success rate.
The state of the art of english language teaching Quinchía, Risaralda

The present study was developed in order to accomplish the first step of the Ordenanza policy. As it corresponds to diagnose the state of the language teaching in eleven regions of Risaralda. In this way, the current research took place in a high school of Quinchia where different data related with teaching methodologies, students, teachers and stakeholder´s perceptions towards the practice of English was collected in order to identify the scenarios of the instruction of the language within the classroom. To succeed the research, the information was collected through questionnaires observations and interviews taking into account the grounded theory in order to complete the process of coding, categorizing and grouping. As the institution has an emphasis in English language the results indicate that students are used to practicing communication of the target language as a major exercise in the classroom, as well as the role of mother tongue, and the teaching process in the EFL classroom. In general terms, the L1 was used as strategy to monitor understanding, instructions and commands. L2 was evidenced and was commonly used for guiding the lessons, working on the writing skill and interacting with the students. Different teaching activities were observed in the classrooms which were aligned to some of the methodologies for English language teaching. The participant´s perceptions informed the student´s opinions about their learning process, practicing and challenges faced in the use of the language and finally the educational needs, language process, preparation and expectations of teachers and stakeholders. Thus, this research was a great contribution to the macro-project the State of the Art of the English Language Teaching in Risaralda that will serve as a diagnosis for further studies concerning the Risaralda Bilingual Project.
Spectral Geometry Processing with Manifold Harmonics

We present an explicit method to compute a generalization of the Fourier Transform on a mesh. It is well known that the eigenfunctions of the Laplace Beltrami operator (Manifold Harmonics) define a function basis allowing for such a transform. However, computing even just a few eigenvectors is out of reach for meshes with more than a few thousand vertices, and storing these eigenvectors is prohibitive for large meshes. To overcome these limitations, we propose a band‐by‐band spectrum computation algorithm and an out‐of‐core implementation that can compute thousands of eigenvectors for meshes with up to a million vertices. We also propose a limited‐memory filtering algorithm, that does not need to store the eigenvectors. Using this latter algorithm, specific frequency bands can be filtered, without needing to compute the entire spectrum. Finally, we demonstrate some applications of our method to interactive convolution geometry filtering. These technical achievements are supported by a solid yet simple theoretic framework based on Discrete Exterior Calculus (DEC). In particular, the issues of symmetry and discretization of the operator are considered with great care.
Comparison of direct voltage control methods of multi-terminal DC (MTDC) networks through modular dynamic models

Estimates are that circa 40GW of offshore wind power capacity is going to be installed throughout Europe by the end of this decade. In this scenario, a pan-European offshore grid network is needed in order to efficiently integrate large amounts of offshore wind into the different European countries' transmission networks. In this paper, the dynamic model of multi-terminal HVDC (MTDC) transmission system composed of voltage-source converters is presented. Afterwards, the dynamic models are used to compare four different methods for controlling the DC voltage inside MTDC networks, viz.: droop control, ratio control, priority control and voltage margin control. Lastly, a case study is performed in a four-node MTDC network and the different control strategies are compared.
Transcranial color-coded duplex sonography in unilateral flow-restrictive extracranial carotid artery disease.

PURPOSE To provide transcranial color-coded duplex flow-velocity data for the basal cerebral arteries in patients with unilateral flow-restrictive extracranial carotid artery disease, and to compare these data with the flow velocities obtained in healthy control subjects. METHODS Transcranial color-coded duplex sonography was performed in 78 patients with different patterns of cross flow through the anterior and posterior communicating arteries associated with unilateral obstruction (70% to 100%; 46 stenoses and 32 occlusions) of the internal carotid arteries. Peak systolic, mean, and end diastolic velocities were measured in the anterior, middle, and precommunicating and postcommunicating posterior cerebral arteries. These measurements were compared with the values obtained in 125 age- and sex-matched health control subjects. RESULTS Patients with anterior communicating artery cross flow to the middle cerebral artery (63%) had increased peak velocity in the anterior cerebral artery and decrease peak velocity in the middle cerebral artery on the obstructed (ipsilateral) side, and increased peak velocity in the anterior cerebral artery on unobstructed (contralateral) side. Patients with anterior communicating artery cross flow to the pericallosal artery (19%) had increased contralateral peak systolic velocity and mean anterior cerebral artery velocities. Patients without anterior communicating artery cross flow (18%) had normal peak velocities in the anterior and middle cerebral arteries. Patients with posterior communicating artery cross flow (42%) had ipsilaterally decreased peak systolic and mean middle cerebral artery velocities and increased peak velocities in the precommunicating posterior cerebral artery. Patients without posterior communicating artery cross flow (58%) had ipsilaterally decreased peak systolic and mean middle cerebral artery velocities. CONCLUSION Our findings suggest that typical abnormalities of basal cerebral artery flow velocities occur in patients with unilateral 70% to 100% obstruction of the internal carotid arteries resulting in different patterns of cross flow through the circle of Willis.
POSTER: State Teleportation via Hardware Transactional Memory

State teleportation is a new technique for exploiting hardware transactional memory (HTM) to improve existing synchronization and memory management schemes for highly-concurrent data structures. When applied to fine-grained locking, a thread holding the lock for a node launches a hardware transaction that traverses multiple successor nodes, acquires the lock for the last node reached, and releases the lock on the starting node, skipping lock acquisitions for intermediate nodes. When applied to lock-free data structures, a thread visiting a node protected by a hazard pointer launches a hardware transaction that traverses multiple successor nodes, and publishes the hazard pointer only for the last node reached, skipping the memory barriers needed to publish intermediate hazard pointers. Experimental results show that these applications of state teleportation can substantially increase the performance of both lock-based and lock-free data structures.
Subjective scaling of smooth surface friction.

1. Six men and four women, 30-51 yr of age, were asked to use the tip of the washed and dried index finger to stroke six different featureless, flat surfaces mounted on a three-dimensional force platform. The six surfaces were rosin-coated glass, glass, satin-finished aluminum, poly-vinyl chloride (PVC) plastic, Teflon, and nyloprint (polyamide plastic). The subjects were requested to indicate where the sensation produced by each surface should be placed on an unidimensional scale represented by an 18cm line labeled at one end by the words "most slippery" and at the other end by the words "most sticky. " The coefficients of friction for each surface and for each subject were subsequently assessed by asking each subject to stroke the surfaces as if they were assessing its slipperiness for 5 s. 2. The finger forces normal and tangential to the stroked surfaces were digitized at 250 Hz and stored on a laboratory computer. The ratio of the mean tangential force to the mean perpendicular force during stroking was used to calculate the mean coefficient of kinetic friction. The mean friction for all subjects ranged from 0.43 for the nyloprint surface to 2.79 for the rosin-coated glass. Correlation coefficients calculated between the subjective estimates of friction and the measured coefficients of friction for each subject individually resulted in a mean correlation of 0.85 (n = 10, P < 0.001). 3. These data indicate that subjects can accurately scale relative differences in the friction of macroscopically smooth, flat surfaces, by modulating the tangential force applied to the finger while keeping the normal force relatively constant. The fact that subjects maintained a relatively constant normal force and instead varied the tangential force across different surfaces suggests that receptors sensitive to these tangential forces are important in the perception of smooth surface friction.