Miracle-dz/UniFAR-FTUs huggingface dataset:
Application of antimicrobial photodynamic therapy in periodontal and peri-implant diseases.

Recent advances in technology have led to a constant drive to develop novel approaches for the treatment of periodontal diseases. The need to ﬁnd more optimal treatment protocols for periodontal disease is a long-term goal for periodontal researchers and clinicians. A novel noninvasive photochemical approach for infection control, namely photodynamic therapy, has been receiving much attention in the treatment of oral diseases (34, 45, 139). Although the original technique was ﬁrst employed in the treatment of cancer (4), during the last decade an increasing number of studies on photodynamic therapy application have been published in periodontics. They have reported efﬁcient elimination of periodontal pathogens using the photodynamic method, which combines the application of a nontoxic chemical agent (photosensitizer) with low-level light energy (25, 37, 115). Photodynamic therapy has been considered as a promising novel therapeutic approach for eradicating pathogenic bacteria in periodontal and peri-implant diseases. In this review article, an overview on the existing preclinical and clinical evidence on the effects of photodynamic therapy in the treatment of periodontal and peri-implant diseases is presented and discussed.
Localization and Genomic Organization of a New Hepatocellular Organic Anion Transporting Polypeptide*

Based on sequence homology to the human organic anion transporting polypeptide 2 (OATP2; SLC21A6), we cloned a new member of the SLC21A superfamily of solute carriers, termed OATP8 (SLC21A8). The protein of 702 amino acids showed an amino acid identity of 80% with human OATP2. Based on Northern blotting, the expression of OATP8 was restricted to human liver. Cosmid clones containing the genes encoding human OATP1 (SLC21A3), OATP2 (SLC21A6), and OATP8 (SLC21A8) served to establish their genomic organization. All three genes contained 14 exons with 13 identical splice sites when transferred to the amino acid sequence. An antibody raised against the carboxyl terminus localized OATP8 to the basolateral membrane of human hepatocytes and the recombinant glycoprotein, expressed in MDCKII cells, to the lateral membrane. Transport properties of OATP8 were studied in stably transfected MDCKII and HEK293 cells. Organic anions transported by human OATP8 included sulfobromophthalein, with aK m of 3.3 μm, and 17β-glucuronosyl estradiol, with a K m of 5.4 μm. Several bile salts were not substrates. Thus, human OATP8 is a new uptake transporter in the basolateral hepatocyte membrane with an overlapping but distinct substrate specificity as compared with OATP2, which is localized to the same membrane domain.
On combining organisational modelling and graphical languages for the development of multiagent systems

This article illustrates the application of the Gaia methodology to the development of a system for Selective Dissemination of Information on the Web, as well as the integration of Gaia with AUML. This allows a concrete design closer to implementation and the developer offers a better insight into the multiagent system that is being built. Gaia is an agent-oriented organisational methodology that generates an abstract model based on roles describing the system agents, their services and interactions. AUML, as an agent-based extension of the graphical language UML, uses that model as input and breaks it down into a series of diagrams that facilitates its implementation.
IDEAL STRUCTURE IN FREE SEMIGROUPOID ALGEBRAS FROM DIRECTED GRAPHS

A free semigroupoid algebra is the weak operator topol- ogy closed algebra generated by the left regular representation of a directed graph. We establish lattice isomorphisms between ideals and invariant subspaces, and this leads to a complete description of the wot-closed ideal structure for these algebras. We prove a distance formula to ideals, and this gives an appropriate version of the Caratheodory interpolation theorem. Our analysis rests on an investigation of predual properties, specifically the An properties for linear functionals, together with a general Wold Decomposi- tion for n-tuples of partial isometries. A number of our proofs unify proofs for subclasses appearing in the literature.
800W UHF SiC SIT transistor for radar applications

The performance of an 800 Watt SiC SIT device using state of the art silicon carbide technology is described. Operating under pulsed RF conditions of 300uS Pulse Width, 10% Duty Cycle, it can deliver 800 Watts peak power at 96 Volts. More than 50% efficiency and 9 dB gain are attained over the bandwidth of 400–450 MHz. The power density is 3.1 Watt/Mil. Thermal resistance is 0.14°C/W. The junction temperature remains below 170°C at a flange temperature of 70°C. This combination of high power density and high voltage operation makes these new generation devices ideally suited for transmitter designs in UHF Radar systems.
Um estudo exploratório sobre colaboração logística em um grande varejo supermercadista

Esta pesquisa tem por objetivo discutir os elementos de colaboracao logistica importantes para a construcao de um melhor relacionamento entre o varejista e seus fornecedores. Esses elementos foram identificados a partir da literatura e observados em um estudo de caso em uma grande rede de varejo supermercadista. As teorias relacionadas a pesquisa sao referentes a natureza da colaboracao, ao desempenho logistico e a economia dos custos de transacao. Dentre os elementos usualmente mais citados para o processo de colaboracao, como confianca, reciprocidade, compartilhamento de informacoes, interacao entre as areas funcionais, objetivos e metas conjuntas, e integracao interpessoal, os resultados sugerem que este ultimo elemento e o mais importante no processo de colaboracao logistica.
Effects of cooperative translation on Chinese EFL student levels of interest and self-efficacy in specialized English translation

Translation instruction is very important in specialized English teaching activities. The effectiveness of current specialized English translation instruction (SETI) in mainland China, however, is unclear because university students have become less interested in, and less confident when doing, English translation. This study investigated the effects of online cooperative translation on EFL students’ levels of interest and self-efficacy with respect to specialized English translation through a questionnaire, focus group interview, interaction data analysis, and pre-test and post-test on 48 second-year college students in China majoring in educational technology. The results showed that online cooperative translations could significantly increase student interest and self-efficacy in specialized English translation. In cooperative translation, student engagement was significantly and linearly correlated with their interest and self-efficacy in translation. We conclude with recommendations on reforming current SETI practices in mainland China's universities.
Hyperspatial and Multi-Source Water Body Mapping: A Framework to Handle Heterogeneities from Observations and Targets over Large Areas

Recent advances in remote sensing technologies and the cost reduction of surveying, along with the importance of natural resources management, present new opportunities for mapping land cover at a very high resolution over large areas. This paper proposes and applies a framework to update hyperspatial resolution (<1 m) land thematic mapping over large areas by handling multi-source and heterogeneous data. This framework deals with heterogeneity both from observation and the targeted features. First, observation diversity comes from the different platform and sensor types (25-cm passive optical and 1-m LiDAR) as well as the different instruments (three cameras and two LiDARs) used in heterogeneous observation conditions (date, time, and sun angle). Second, the local heterogeneity of the targeted features results from their within-type diversity and neighborhood effects. This framework is applied to surface water bodies in the southern part of Belgium (17,000 km2). This makes it possible to handle both observation and landscape contextual heterogeneity by mapping observation conditions, stratifying spatially and applying ad hoc classification procedures. The proposed framework detects 83% of the water bodies—if swimming pools are not taken into account—and more than 98% of those water bodies greater than 100 m2, with an edge accuracy below 1 m over large areas.
Validity of Energy Intake Reports in Relation to Dietary Patterns

The role of under- and overreporting of energy intake in determining the dietary patterns is yet unclear, especially in the Middle Eastern countries. This study identifies the prevalence of misreporting among Tehranian women aged 18-45 years and to compare the dietary intake patterns of plausible and all energy reporters. Dietary intakes and anthropometric data were collected. FitMate™ metabolic analyzer and Goldberg equation were used in determining the under/overreporting of energy intake. Underreporters were more likely to be overweight and older compared to plausible reporters. Three dietary patterns emerged for all reporters, and two were identified for plausible reporters. Using only plausible reporters to determine dietary patterns was not similar to using all reporters. The proportion of underreporters was 59.3% in the mixture cluster, 30.4% in the unhealthy cluster, and 35.3% in the healthy cluster (p<0.05). Underreporting of energy intake is not uniformly distributed among dietary pattern clusters and tends to be less severe among subjects in the unhealthy cluster. Our data suggested that misreporting of energy intake might affect the dietary pattern analysis.
Towards a “ Synchronous Reactive ” UML subprofile ?

The domain of Real-Time Embedded (RTE) systems was ackowledged as being largely influencial on many feature additions to the upcoming UML2.0 standard [1]. Work on UML1.4 Scheduling, Performance & Time(SPT) profile also goes in that direction. Still, the generic paradigms underlying these modeling efforts is that of software components, running on a real-time OSs with physical time constraints and middleware (e.g., RT-Corba) concerns. In other areas of Embedded System Design other paradigms are at work, owing to codesign techniques at the border between software and hardware, or discrete time mathematical engineering (MATLAB/Simulink) and DSP algorithms, etc. The paradigm of Synchronous Reactive (S/R) systems [2, 3], with discrete logical time and behavior decomposition into instantaneous reactions, proved quite natural in such areas to model mixed HW/SW System-Level Design (SLD). We describe here some of the modeling paradigms needed for a true S/R model framework, and corresponding diagrammatic interpretations.
Triterpenoids from Ganoderma lucidum and their cytotoxic activities

From the ethyl acetate fraction of the fruiting body of Ganoderma lucidum, a new triterpenoid, ethyl 7β-hydroxy-4,4,14α-trimethyl-3,11,15-trioxo-5α-chol-8-en-24-oate (4), named ethyl lucidenates A, along with three known compounds, ganodermanondiol (1), lucidumol B (2) and methyl lucidenates A (3) were isolated by silica gel column, ODS column chromatography and PHPLC. Their structures were established on the basis of spectroscopic analysis and chemical evidence. The isolated compounds were tested using in vitro MTT assay for their cytotoxic activities against the K562, HL-60, CA46, HepG2, SW480 and SMMC-7221 cancer cell lines. Among them, compound 4 showed cytotoxicity against HL-60 and CA46 cancer cell lines with IC50 values of 25.98 and 20.42 µg mL−1, respectively.
Inhibition of Rho Kinases Enhances the Degradation of Mutant Huntingtin*

Huntington disease (HD) is a fatal hereditary neurodegenerative disease caused by an expansion of the polyglutamine (polyQ) stretch in huntingtin (htt). Whereas the pathological significance of the expanded polyQ has been clearly established and a tremendous effort to develop therapeutic tools for HD has been exerted, there is yet no effective cure. Whereas many molecules able to reduce the polyQ accumulation and aggregation have been identified, including several Rho kinase (ROCK) inhibitors, it remains very important to determine the mechanism of action of the potential drugs. ROCK inhibitors, including Y-27632 were reported to decrease aggregation of htt and androgen receptor (AR) through ROCK1 and protein kinase C-related protein kinase-2 (PRK-2). A downstream effector of ROCK1, actin-binding factor profilin, was shown to inhibit the mutant htt aggregation but not AR by direct interaction. We found that the anti-aggregation effect of ROCK inhibitors was not limited to the mutant htt and AR and that Y-27632 was also able to reduce the aggregation of ataxin-3 and atrophin-1 with expanded polyQ. These results suggested that in addition to the mechanism reported for htt and AR, there might also be other common mediators involved in the reduced aggregation of different polyQ proteins. In this study, we show that Y-27632 not only reduced the mutant htt aggregation by enhancing its degradation, but surprisingly was able to activate the main cellular degradation pathways, proteasome, and macroautophagy. We also show that this unique effect was mediated by ROCK1 and ROCK2.
Insomnia, Sleepiness, and Depression in Adolescents Living in Residential Care Facilities

The main objective of this study was to document sleep patterns and disturbances reported by youths temporarily living in residential care facilities. A secondary objective was to examine the relationships between sleep disturbances and mood and daytime sleepiness. A self-reported questionnaire on sleep patterns and habits assessing duration, frequency, and consequences of sleep difficulties, the Beck Depression Inventory-2, and the Epworth Sleepiness Scale were administered to a sample of 66 adolescents. Results suggest a high rate of sleep disturbances in this sample, with 41% reporting insomnia symptoms and 21% meeting diagnostic criteria for an insomnia syndrome. Those with more severe insomnia syndrome showed more severe depressive symptoms and daytime consequences.
Research on Multi-document Summarization Based on LDA Topic Model

Compared with VSM (Vector Space Model) and graph-ranking models, LDA (Latent Dirichlet Allocation) Model can discover latent topics in the corpus and latent topics are beneficial to use sentence-ranking mechanisms to form a good summary. In the paper, based on LDA Model, a new method of sentence-ranking is proposed. The method combines topic-distribution of each sentence with topic-importance of the corpus together to calculate the posterior probability of the sentence, and then, based on the posterior probability, it selects sentences to form a summary. Topic-distribution of each sentence represents the likelihood of sentence belonging to each topic and topic-importance represents the degree that the topics cover the significant portion of the corpus. The method highlights the latent topics and optimizes the summarization. Experiment results on the dataset DUC2006 show the advantage of the multi-document summarization algorithm proposed in the paper. ROUGE values are improved compared with those methods, such as LexRank, LDA-SIBS, LDA-PGS.
Association of interleukin genes polymorphism with asthma susceptibility in Indian children: a case-control study

Abstract Background: Interleukins (IL) 4 and 13 genes and their receptors (R) are the key cytokines which amplify inflammatory reactions in asthma. Objective: This study aimed to investigate the association of IL 4, 4 R, 13 and 13 R genes polymorphism with asthma in Indian children. Methods: In this hospital-based case-control study, included were children aged 1–15 years recruited as diagnosed cases of bronchial asthma, according to EPR 2007 and excluded were subjects with other respiratory diseases. Children with no present or past history of asthma were enrolled as controls. Spirometry was done in cases age ≥ 6 years. Gene–gene interaction was evaluated using binary logistic regression. Results: From October 2010 to July 2013, 275 cases and 275 controls were recruited. Gene–gene interactions between C1112T in IL 13 and Ile50Val in IL 4 R gene polymorphisms were found to be statistically significant (OR = 2.37, 95% CI = 1.04–5.42, p = 0.040). Individuals with CT and GG genotype of C1112T in IL 13 and Ile50Val in IL 4 R were at twice the risk for the development of asthma compared to individuals with both non-risk genotypes. Conclusion: The data suggests that gene–gene interactions between IL 13 and IL 4 R genes may play an important role in asthma among Indian children.
Organisation as Interpretative Systems

[eng] In standard economies incentives matter but interpretation is ignored. But in Knightian uncertainty there are no assured procedures ; knowledge is a conjectural organisation imposed on phenomena, as Adam Smith showed, and specialisation encourages the differentiation of knowledge systems. The evolution of human cognition favoured context-specific pattem making by individuals, and the adoption of particular patterns within groups. This is the cognitive basis of formal organisations, each of which requires a cluster of compatible patterns ; but since ail patterns are both fallible and restrictive, variety between organisations is desirable. Innovation is a reorganisation of patterns, which may be difficult. [fre] En economie standard les incitations comptent mais l'interpretation est ignoree. Cependant en incertitude knightienne il n'y a pas de procedures certaines ; la connaissance est une organisation conjecturelle imposee aux phenomenes, comme l'a montre Adam Smith, et la specialisation encourage la differenciation des systemes de connaissance. L'evolution du processus de connaissance humaine a favorise l'etablissement de schemas specifiques vis-a-vis du contexte par les individus, et l'adoption de schemas particuliers au sein des groupes. Ici reside le fondement cognitif des organisations formelles, chacune supposant un ensemble de schemas compatibles ; cependant tout schema etant a la fois faillible et restrictif, la variete parmi les organisations est souhaitable. L'innovation constitue une reorganisation des schemas, qui peut se reveler difficile.
The American Colonies

How does one recognize the looming inevitable? In the 1760s, the British, having defeated the French in America and expanded George III’s overseas empire, saw only profit and prestige ahead. A New England cleric, the Reverend Samuel Cooper, told his congregation that the colonists were indebted “not only for their present Security and Happiness, but, perhaps for their very Being, to the paternal Care of the Monarch. ” The legitimacy of royal rule was little questioned. In that future seedbed of sedition, Boston, Thomas Foxcroft declared, “Above all, we owe our humble Thanks to his Majesty and with loyal Hearts full of joyous Gratitude, we bless the King, for his Paternal Goodness in sending such effectual Aids to his American Subjects. when we needed the Royal Protection. ”
Clinician's Guide to cardiopulmonary exercise testing in adults: a scientific statement from the American Heart Association.

Exercise testing remains a remarkably durable and versatile tool that provides valuable diagnostic and prognostic information regarding patients with cardiovascular and pulmonary disease. Exercise testing has been available for more than a half century and, like many other cardiovascular procedures, has evolved in its technology and scope. When combined with exercise testing, adjunctive imaging modalities offer greater diagnostic accuracy, additional information regarding cardiac structure and function, and additional prognostic information. Similarly, the addition of ventilatory gas exchange measurements during exercise testing provides a wide array of unique and clinically useful incremental information that heretofore has been poorly understood and underutilized by the practicing clinician. The reasons for this are many and include the requirement for additional equipment (cardiopulmonary exercise testing [CPX] systems), personnel who are proficient in the administration and interpretation of these tests, limited or absence of training of cardiovascular specialists and limited training by pulmonary specialists in this technique, and the lack of understanding of the value of CPX by practicing clinicians. Modern CPX systems allow for the analysis of gas exchange at rest, during exercise, and during recovery and yield breath-by-breath measures of oxygen uptake (Vo2), carbon dioxide output (Vco2), and ventilation (Ve). These advanced computerized systems provide both simple and complex analyses of these data that are easy to retrieve and store, which makes CPX available for widespread use. These data can be readily integrated with standard variables measured during exercise testing, including heart rate, blood pressure, work rate, electrocardiography findings, and symptoms, to provide a comprehensive assessment of exercise tolerance and exercise responses. CPX can even be performed with adjunctive imaging modalities for additional diagnostic assessment. Hence, CPX offers the clinician the ability to obtain a wealth of information beyond standard exercise electrocardiography testing that when appropriately applied and interpreted …
Query classification using topic models and support vector machine

This paper describes a query classification system for a specialized domain. We take as a case study queries asked to a search engine of an art, cultural and history library and classify them against the library cataloguing categories. We show how click-through links, i.e., the links that a user clicks after submitting a query, can be exploited for extracting information useful to enrich the query as well as for creating the training set for a machine learning based classifier. Moreover, we show how Topic Model can be exploited to further enrich the query with hidden topics induced from the library meta-data. The experimental evaluations show that this system considerably outperforms a matching and ranking classification approach, where queries (and categories) were also enriched with similar information.
Examining Social Capital as a Mechanism for Improving School Engagement Among Low Income Hispanic Girls

Hispanic females are a rapidly growing population and are now considered the largest group of ethnic minority girls in the United States. Yet research to guide their educational needs remains sparse. Addressing this concern, this investigation incorporated a strengths-based approach for examining school engagement among Hispanic middle school girls. A path model predicting school engagement was tested that included a neighborhood environment variable (e.g., neighborhood dangerousness) and variables to assess social capital (e.g., teacher support, friend support, and parent support). The hypothesized model was found to fit data from the sample and showed the positive and direct effects of teacher support, friend support, and parent support on school engagement, and further demonstrated that the perceived absence of neighborhood dangerousness was positively and directly associated with engagement in school. Implications for school-based interventions for Latina youth are discussed.