Miracle-dz/UniFAR-FTUs huggingface dataset:
Enhancing Course Reusability through XML Schemas Integration

L’utilisation croissante du langage XML dans le domaine de l’education est a la base de la conception de modeles de documents elabores, que ce soit via des DTD ou, plus recemment via des schemas XML, visant a refleter la structure semantique de contenus pedagogiques. L’existence de tels modeles a favorise la production et la disponibilite de telles ressources, toutefois structurees de maniere heterogene. Dans un tel contexte, partager et reutiliser des ressources existantes s’avere d’un interet incontestable, a la fois en termes d’interoperabilite entre les applications et entre les differents auteurs. Le projet FAVORITE decrit notre approche basee sur l’integration de schemas XML en vue de repondre a deux besoins essentiels en termes de reutilisabilite : l’acces aux donnees pedagogiques et leur adaptation a un contexte specifique. D’une part, l’acces aux donnees est procure au travers d’un schema unifie ; d’autre part, sur cette base, nous facilitons leur adaptation a un nouveau contexte en degageant les contraintes structurelles et semantiques susceptibles d’etre source de conflits.
Resistive switching via the converse magnetoelectric effect in ferromagnetic multilayers on ferroelectric substrates

A voltage-controlled resistive switching is predicted for ferromagnetic multilayers and spin valves mechanically coupled to a ferroelectric substrate. The switching between low- and high-resistance states results from the strain-driven magnetization reorientations by about 90°, which are shown to occur in ferromagnetic layers with a high magnetostriction and weak cubic magnetocrystalline anisotropy. Such reorientations, not requiring external magnetic fields, can be realized experimentally by applying moderate electric field to a thick substrate (bulk or membrane type) made of a relaxor ferroelectric having ultrahigh piezoelectric coefficients. The proposed multiferroic hybrids exhibiting giant magnetoresistance may be employed as electric-write nonvolatile magnetic memory cells with nondestructive readout.
Toward a subjective synchronous communication in multimodal human-machine interaction: Intention of movement alternates simultaneous perception in auditory-tactile temporal order judgment

We investigated the effect of voluntary movement on temporal multimodal integration using a psychological experiment. The present study used auditory-tactile Temporal Order Judgment (TOJ) task to measure the differences in Point of Subjective Simultaneity (PSS) and Just Noticeable Difference (JND). To distinguish the effect of voluntary movement and proprioceptive feedback, we prepared three conditions: Voluntary condition, Involuntary condition, and No-movement condition. Voluntary movement and Involuntary movement shifted PSS to the point where an auditory stimulus presented prior to a tactile stimulus compared to No-movement condition. Furthermore, the shift of PSS in Voluntary condition was larger than that in Involuntary condition. JND of Voluntary condition was smaller than those of the other two conditions. These results revealed that voluntary movement improved temporal resolution between auditory and tactile stimuli. Moreover, it was demonstrated that voluntary movement also alternates audio-tactile temporal integration.
Microvessel Landscape Assessment in Pancreatic Ductal Adenocarcinoma: Unclear Value of Targeting Endoglin (CD105) as Prognostic Factor of Clinical Outcome

Objectives Tumor angiogenesis based on microvessel density assessment has been associated with poor prognosis in several studies of patients with pancreatic ductal adenocarcinoma (PDAC). Expression of endoglin (CD105), a tumor-induced vascularization marker, has been found to represent a negative prognostic factor in many malignant tumors. The aim of our study was to assess the value of tumoral microvascularity both with pan-endothelial markers and endoglin as well, in correlation with the clinical outcome of patients with PDAC. Methods Fifty-eight patients with PDAC, 36 males and 22 females, with a mean (SD) age of 65.4 (10.0) years were included in the study. Deparaffinized sections from formalin-fixed areas both from the center and periphery (invasion front) of the tumors were immunostained for CD105 as well as for the endothelial markers CD31 and CD34. Tumoral angiogenesis was assessed on the basis of microvessel density (number of vessels per square millimeter) and on microvascular area (square micrometers) as well. Results High intratumoral microvascular area, in endoglin-stained sections, was found to be of marginal prognostic significance for recurrence (log rank, P 0.05). Survival was also marginally associated with CD31 intratumoral microvascular area (log rank, P 0.05). Conclusions Further studies are needed before endoglin replaces the conventional angiogenesis markers in PDCA.
Integrated n-best re-ranking for spoken language translation

This paper describes the application of N-best lists to a spoken language translation system. Multiple hypotheses are generated both by the speech recognizer and by the statistical machine translator; they are ﬁnally re-ranked by optimally weighting recognition and translation scores, estimated in an integrated scheme. We provide experimental results for the Italian-to-English direction on the BTEC corpus, a collection of sentences in the touristic domain developed within the C-STAR project.
Refusal of Autonomy: the Use of Words by a Young Adult in Analysis

Analytic work with a depressed twenty-three-year-old woman is presented showing how she used ruminative thoughts to maintain a fixed internal dyadic relationship in which neither self not object had autonomy. The resulting omnipotent/impotent impasse meant that she was unable to move forward in her development. In the analysis this relationship was externalized through her use of words, which were employed as actions designed to have a concrete effect on both her self and her analyst. For a long period in the analysis it was essential to understand and interpret the function of her words, rather than to look for symbolic meaning, and it was this which gradually enabled her to take a third, observing, position from which she had greater freedom to operate as an adult.
Bounded Selective Spanning With Extended Fast Enumeration for MIMO-OFDM Systems Detection

Sphere decoders allow receivers in multiple-input multiple-output (MIMO) communications systems to detect QAM symbols with quasi-optimal accuracy and low complexity compared with the ideal maximum likelihood detector. However, their high complexity relative to simple linear detectors means that the latter are still usually adopted, despite their lower detection performance. Configurable sphere decoders, such as selective spanning fast enumeration (SSFE), allow complexity to be reduced at the cost of lower performance and are hence ideal for transceivers for Internet-of-Things equipment, where scale, operating context and resource, and energy budgets vary dramatically. However, SSFE still suffers performance limitations due to the internal heuristics employed for symbol selection and enumeration and real time, and software-defined realizations for even moderately demanding MIMO standards, such as 802.11n, have not been recorded. This paper presents a new variant of SSFE which, by employing novel fast symbol enumeration and modulation dictionary spanning heuristics, increases performance and computational efficiency to the point where very substantial reductions in resource can be achieved without impacting detection accuracy relative to SSFE. This is demonstrated via a series of field programmable gate array-based detectors $2 \times 2$ and $4 \times 4$ , 16-QAM 802.11n MIMO.
Associations among 25-hydroxyvitamin D, diet quality, and metabolic disturbance differ by adiposity in adults in the United States.

CONTEXT Recent evidence indicates that a higher plasma level of 25-hydroxyvitamin D [25(OH)D] is associated with lower adiposity and a reduced number of metabolic disturbances (MetD). OBJECTIVES We examined associations among dietary quality, 25(OH)D, percent body fat (%BF), and MetD, and a pathway linking them, across central obesity. DESIGN This cross-sectional nationally representative study used extensive data from the National Health and Nutrition Examination Surveys of 2001-2004. PARTICIPANTS U.S. adults aged at least 20 yr were stratified by central obesity (CO) status. Sample sizes ranged from 1943 (all MetD combined) to 7796 (each component). MAIN OUTCOME MEASURES %BF was measured using dual-energy x-ray absorptiometry, and MetD was measured with individual continuous nonadiposity outcomes (e.g. fasting plasma glucose) and with a composite count index of binary MetD with prespecified cutoff points (Index I). RESULTS A higher 25(OH)D was associated with better dietary quality, lower %BF, and lower number of MetD. These inverse 25(OH)D-%BF and 25(OH)D-MetD associations (i.e. fasting blood glucose, homeostatic model assessment of insulin resistance, C-reactive protein, and Index I) were significantly stronger among the CO+ group. Finally, the pathway linking the dairy component of the Healthy Eating Index (HEIdairy) to Index I through 25(OH)D and %BF indicated complete mediation among the CO- group, but HEIdairy and 25(OH)D had direct inverse associations with Index I among the CO+ group. CONCLUSIONS Due to potential genetic differences between CO- and CO+ groups, empowering U.S. adults with central obesity to make related behavioral changes may be especially effective in improving their vitamin D status and metabolic profile.
Inversions of New Hope

First introduced as a new protocol implemented in Chrome Canary for the Google Inc. Chrome browser, New Hope is engineered as a post-quantum key exchange for the TLS 1.2 protocol. The structure of the exchange is a combination of elliptic curve enhancements along with revised lattice-based cryptography. New Hope incorporates the key-encapsulation mechanism of Peikert which itself is a modified Ring-LWE scheme. The closest-vector problem is generated with an intersection of tesseract and hexadecachoron which results in the 24-cell V. With respect to the density of the Voronoi cell V, the proposed mitigation against backdoor attacks proposed by the authors of New Hope only occurs against passive attacks. We show that a backdoor as an active attack, formalized as an inversion oracle, is successful.
TĖVŲ AUKLĖJIMO STILIAUS IR EMOCINIO INTELEKTO SĄSAJOS SU VYRESNIŲJŲ PAAUGLIŲ SAVIVEIKSMINGUMU BEI SAVIVERTE PAGAL LYTĮ

Summary Previous studies have found that parenting styles predict childrens’ emotional intelligence, i.e., their ability to perceive, express and manage their emotions. Parenting styles were also found to predict the self-efficacy and self-esteem of adolescents. Despite a high interest in the effects of parenting on the emotional charateristics and adjustment indicators of adolescents, researchers have rarely analysed the effects of gender on these links. Previous data suggest that adolescent boys have a higher self-esteem as compared with girls, while findings on gender differences in emotional intelligence are mixed. Moreover, some effects of the interaction between parents’ and adolescents’ gender have been found significant when predicting the adjustment of adolescents. The present study explores the way in which parenting styles and adolescents’ emotional intelligence (perception and understanding of emotions, expression and labeling of emotions, and managing and regulating emotions) predict the self-esteem and self-efficacy of adolescent boys and girls. Data for this analysis were taken from a longitudinal study in high schools of the Klaipėda region. The sample consisted of 1028 adolescents (624 girls and 404 boys) aged 16 to 18 (M = 16.29, SD = 0.93). The participants filled in the Rosenberg’s Self-Esteem Scale (RSE, Rosenberg, 1965), parenting styles questionnaire (EMBU: Egna Minnen Betraffande Uppfostran, Arrindell et al., 1994), the Emotional Skills and Competence Questionnaire (ESCQ-45, Taksic et al, 2009), and the Generalized Self-efficacy Scale (GSE, Schwarzer and Jerusalem, 1995). The results revealed significant gender effects: girls scored higher on all subscales of emotional intelligence (perception and understanding, expression and labeling, and managing and regulating emotions), including the total emotional intelligence score. In line with the previous studies, self-efficacy did not differ by gender, but boys had a higher self-esteem as compared with girls. Both parents showed more emotional warmth to their daughters, while fathers (but not mothers) showed more rejection towards their sons. Of all parenting styles, parental emotional warmth had the strongest links with the emotional intelligence of adolescent girls and boys. The other links between parenting styles and adolescents’ emotional intelligence were gender-dependent in both parents and adolescents. Self-esteem and self-efficacy in adolescents were strongly predicted by their emotional intelligence scores, whereas parenting styles (father’s emotional warmth) were only important in predicting boys’ self-esteem. Key words: parenting styles, emotional intelligence, self-esteem, self-efficacy, adolescence.
The Cell Cycle Regulator CCDC6 Is a Key Target of RNA-Binding Protein EWS

Genetic translocation of EWSR1 to ETS transcription factor coding region is considered as primary cause for Ewing sarcoma. Previous studies focused on the biology of chimeric transcription factors formed due to this translocation. However, the physiological consequences of heterozygous EWSR1 loss in these tumors have largely remained elusive. Previously, we have identified various mRNAs bound to EWS using PAR-CLIP. In this study, we demonstrate CCDC6, a known cell cycle regulator protein, as a novel target regulated by EWS. siRNA mediated down regulation of EWS caused an elevated apoptosis in cells in a CCDC6-dependant manner. This effect was rescued upon re-expression of CCDC6. This study provides evidence for a novel functional link through which wild-type EWS operates in a target-dependant manner in Ewing sarcoma.
Analogous Mechanisms of Resistance to Benzothiazinones and Dinitrobenzamides in Mycobacterium smegmatis

Tuberculosis is still a leading cause of death worldwide. The selection and spread of Mycobacterium tuberculosis multidrug-resistant (MDR-TB) and extensively drug-resistant strains (XDR-TB) is a severe public health problem. Recently, two different classes of chemical series, the benzothiazinones (BTZ) and the dinitrobenzamide (DNB) derivatives have been found to be highly active against M. tuberculosis, including XDR-TB strains. The target of BTZs is DprE1 protein which works in concert with DprE2 to form the heteromeric decaprenylphosphoryl-β-D-ribose 2′-epimerase, involved in Decaprenyl-Phospho-Arabinose (DPA) biosynthesis. Interestingly, it has been shown that the DNBs block the same pathway thus suggesting that both drugs could share the same target. Moreover, in Mycobacterium smegmatis the overexpression of the NfnB nitroreductase led to the inactivation of the BTZs by reduction of a critical nitro-group to an amino-group. In this work several spontaneous M. smegmatis mutants resistant to DNBs were isolated. Sixteen mutants, showing high levels of DNB resistance, exhibited a mutation in the Cys394 of DprE1. Using fluorescence titration and mass spectrometry it has been possible to monitor the binding between DprE1 and DNBs, achieving direct evidence that MSMEG_6382 is the cellular target of DNBs in mycobacteria. Additionally, M. smegmatis mutants having low levels of resistance to DNBs harbor various mutations in MSMEG_6503 gene encoding the transcriptional repressor of the nitroreductase NfnB. By LC/MS2 analysis it has been demonstrated that NfnB is responsible for DNB inactivation. Taken together, our data demonstrate that both DNB and BTZ drugs share common resistance mechanisms in M. smegmatis.
Genetic and biochemical analysis of the fission yeast ribonucleoprotein particle containing a homolog of Srp54p

Mammalian signal recognition particle (SRP), a complex of six polypeptides and one 7SL RNA molecule, is required for targeting nascent presecretory proteins to the endoplasmic reticulum (ER). Earlier work identified a Schizosaccharomyces pombe homolog of human SRP RNA and showed that it is a component of a particle similar in size and biochemical properties to mammalian SRP. The recent cloning of the gene encoding a fission yeast protein homologous to Srp54p has made possible further characterization of the subunit structure, subcellular distribution, and assembly of fission yeast SRP. S. pombe SRP RNA and Srp54p co-sediment on a sucrose velocity gradient and coimmunoprecipitate, indicating that they reside in the same complex. In vitro assays demonstrate that fission yeast Srp54p binds under stringent conditions to E. coli SRP RNA, which consists essentially of domain IV, but not to the full-length cognate RNA nor to an RNA in which domain III has been deleted in an effort to mirror the structure of bacterial homologs. Moreover, the association of S. pombe Srp54p with SRP RNA in vivo is disrupted by conditional mutations not only in domain IV, which contains its binding site, but in domains I and III, suggesting that the particle may assemble cooperatively. The growth defects conferred by mutations throughout SRP RNA can be suppressed by overexpression of Srp54p, and the degree to which growth is restored correlates inversely with the severity of the reduction in protein binding. Conditional mutations in SRP RNA also reduce its sedimentation with the ribosome/membrane pellet during cell fractionation. Finally, immunoprecipitation under native conditions of an SRP-enriched fraction from [35S]-labeled fission yeast cells suggests that five additional polypeptides are complexed with Srp54p; each of these proteins is similar in size to a constituent of mammalian SRP, implying that the subunit structure of this ribonucleoprotein is conserved over vast evolutionary distances.
Outcomes of laser in situ keratomileusis in a Refractive Surgery fellowship program.

PURPOSE The purpose of this study was to document the learning curve and evaluate the success of laser in situ keratomileusis (LASIK) performed by fellows in a Cornea/External Disease and Refractive fellowship program. METHODS Two surgeons performed LASIK within a fellowship training program between July 2000 and August 2001. A retrospective review was conducted to determine the visual outcomes and operative complications from this non-comparative case series of 755 consecutive eyes. All LASIK procedures were performed using a Bausch & Lomb Technolas 217A laser and the Bausch & Lomb Hansatome or the Automated Corneal Shaper microkeratome. All eyes were evaluated for operative complications. Visual acuity was reported with a minimum of 1 month follow-up. RESULTS Data analysis revealed that uncorrected visual acuity of 20/40 or better was attained in 99.4% of treated eyes, and 20/20 or better in 77.2%. With both eyes open, 100% of patients saw 20/30 or better, 94% saw 20/20 or better, 70% saw 20/15 or better, and 5.5% saw 20/10. Flap related complications occurred in 7 of 755 eyes (0.9%) and all were successfully treated. Forty-two eyes (5.6%) were lost to follow-up prior to the 1-month examination and were excluded from analysis of visual acuity. CONCLUSIONS Favorable operative and visual acuity 1-month results in 755 eyes after LASIK with the Bausch & Lomb Technolas 217A laser were in part due to a well organized system of education, patient examination, execution of surgery, and postoperative care. A team approach was essential.
StoreSim: Optimizing Information Leakage in Multicloud Storage Services

Many schemes have been recently advanced for storing data on multiple clouds. Distributing data over different cloud storage providers (CSPs) automatically provides users with a certain degree of information leakage control, as no single point of attack can leak all user's information. However, unplanned distribution of data chunks can lead to high information disclosure even while using multiple clouds. In this paper, to address this problem we present StoreSim, an information leakage aware storage system in multicloud. StoreSim aims to store syntactically similar data on the same cloud, thus minimizing the user's information leakage across multiple clouds. We design an approximate algorithm to efficiently generate similarity-preserving signatures for data chunks based on MinHash and Bloom filter, and also design a function to compute the information leakage based on these signatures. Next, we present an effective storage plan generation algorithm based on clustering for distributing data chunks with minimal information leakage across multiple clouds. Finally, we evaluate our scheme using two real datasets from Wikipedia and GitHub. We show that our scheme can reduce the information leakage by up to 60% compared to unplanned placement.
Isolation and Characterization of Rhesus Monkey Milk Lactoferrin

ABSTRACT. Rhesus monkey milk lactoferrin was isolated and its characteristics compared with those of human milk lactoferrin in order to assess the feasibility of using the rhesus monkey as an animal model for the study of iron absorption from milk. Monkey lactoferrin was isolated from pooled monkey milk by two chromatographic steps. Concentration of lactoferrin in milk, determined by rocket immunoelectrophoresis, demonstrated similar concentrations in both human and monkey milk, 1–2 mg/ml. Immunodiffusion of lactoferrins from several species using an antibody raised to money lactoferrin resulted in a crossreaction only with monkey and human lactoferrin. Lactoferrins from cow, sheep, goat, dog, and rat milk were not recognized by the antibody. Amino acid analysis of monkey lactoferrin showed a composition very similar to human lactoferrin, as well as a similarity in the unusual amino acid sequence at the N-terminal of the protein. The carbohydrate moiety of monkey lactoferrin was investigated and shown to contain monosaccharides in similar proportions to those reported for human lactoferrin. In our opinion, the rhesus monkey is a promising model for the study of the role of lactoferrin in iron absorption in the infant, as well as of the other proposed actions of lactoferrin.
Evaluation of high-resolution cone beam computed tomography in the detection of simulated interradicular bone lesions.

OBJECTIVES The purpose of this study is to assess the accuracy of limited-volume high-resolution cone beam CT (CBCT) in the detection of periodontal bone loss. METHODS 163 simulated periodontal lesions of different depths were created in dried human hemimandibles. Specimens were imaged using the intraoral paralleling technique and limited-volume CBCT (3DX Accuitomo; Morita Co. Ltd, Kyoto, Japan). Ten viewers examined the images. Data were analysed with receiver operating characteristics (ROC) analysis. ROC curves were generated and the areas under the maximum-likelihood curves (A(z)) were compared. Other statistical analyses were used to detect the normality of the distribution of the results. RESULTS The results are reported as the individual viewer ROC curve areas for each of the two imaging modalities. In all experiments the A(z) area for CBCT (0.770-0.864) was larger than the A(z) area for periapical film (0.678-0.783); statistical tests showed a statistically significant difference between the two modalities. CONCLUSIONS Results indicate that the CBCT technique has better accuracy and diagnostic value than periapical films in the detection of interradicular periodontal bone defects.