Miracle-dz/UniFAR-FTUs huggingface dataset:
Breast Cancer Profile in a Group of Patients Followed up at the Radiation Therapy Unit of the Yaounde General Hospital, Cameroon

Objective. To describe the profile of breast cancer in the patients attending the radiation therapy unit of Yaounde General Hospital. Method. From 1989 to 2009, we conducted a descriptive retrospective study based on the register and medical records of patients. Results. During the study period, 531 breast cancer patients were recorded of which 0.75% were male. Age range was 18 to 82 years, with a mean of 45.17 years. Out of these, 66.1% were less than 50 years old and 31.9% less than 40. Self detection was the discovery method in most cases (95.34% of patients). Mean delay before presentation at hospital was 10.35 months, and 54.94% had used traditional medicine before medical evaluation. Metastasis and locally advanced breast cancer at diagnosis were present in 08.13% and 62.78%, respectively. Mastectomy was used in 88.08% of patients. Conclusion. The study reinforces the position occupied by late presentation and advanced stage at diagnosis of breast cancer profile in developing countries.
Performance parameters for grid-connected PV systems

The use of appropriate performance parameters facilitates the comparison of grid-connected photovoltaic (PV) systems that may differ with respect to design, technology, or geographic location. Four performance parameters that define the overall system performance with respect to the energy production, solar resource, and overall effect of system losses are the following: final PV system yield, reference yield, performance ratio, and PVUSA rating. These performance parameters are discussed for their suitability in providing desired information for PV system design and performance evaluation and are demonstrated for a variety of technologies, designs, and geographic locations. Also discussed are methodologies for determining system a.c. power ratings in the design phase using multipliers developed from measured performance parameters.
Mesenchymal Progenitor Cells Differentiate into an Endothelial Phenotype, Enhance Vascular Density, and Improve Heart Function in a Rat Cellular Cardiomyoplasty Model

Background—Cellular cardiomyoplasty is a promising approach to improve postinfarcted cardiac function. The differentiation pathways of engrafted mesenchymal progenitor cells (MPCs) and their effects on the left ventricular function in a rat myocardial infarct heart model were analyzed. Methods and Results—A ligation model of left coronary artery of Lewis rats was used. MPCs were isolated by bone marrow cell adherence. Seven days after ligation, MPCs labeled with 4′,6-diamidino-2′-phenylindole were injected into the infarcted myocardium (n=8). Culture medium was injected in the infarcted myocardium of control animals (n=8). Thirty days after implantation, immunofluorescence studies revealed some engrafted cells expressing a smooth muscle phenotype (&agr; SM actin+), as similarly observed in culture. Other engrafted cells lost their smooth muscle phenotype and acquired an endothelial phenotype (CD31+). Furthermore, vessel density was augmented in the MPC group in comparison with the control group. After 30 days, echocardiography showed an improvement on left ventricular performance in the MPCs compared with the control group. Conclusions—In vivo administration of syngenic MPCs into a rat model of myocardial infarcted heart was safety demonstrated. Some engrafted cells appeared to differentiate into endothelial cells and loss their smooth muscle phenotype. MPC engraftment might to contribute to the improvement on the cardiac function in such a setting.
The cyclophilin inhibitor Debio 025 combined with PEG IFNα2a significantly reduces viral load in treatment‐naïve hepatitis C patients

The anti–hepatitis C virus (HCV) effect and safety of three different oral doses of the cyclophilin inhibitor Debio 025 in combination with pegylated interferon‐α2a (PEG IFN‐α2a) were investigated in a multicenter, randomized, double‐blind, placebo‐controlled escalating dose‐ranging phase II study in treatment‐naïve patients with chronic hepatitis C. Doses of 200, 600, and 1,000 mg/day Debio 025 in combination with PEG IFN‐α2a 180 μg/week for 4 weeks were compared with monotherapy with either 1,000 mg/day Debio 025 or 180 μg/week PEG IFN‐α2a. In patients with genotypes 1 and 4, the 600‐ and 1,000‐mg combination treatments induced a continuous decay in viral load that reached −4.61 ± 1.88 and −4.75 ± 2.19 log10 IU/mL at week 4, respectively. In patients with genotypes 2 and 3, HCV RNA levels at week 4 were reduced by −5.91 ± 1.11 and −5.89 ± 0.43 log10 IU/mL, respectively, with the same treatment regimens. Adverse events were comparable between treatment groups apart from a higher incidence of neutropenia associated with PEG IFN‐α2a and an increased incidence of isolated hyperbilirubinemia at the highest dose of Debio 025 (1,000 mg/day). Conclusion: These results confirm that Debio 025 has a potent activity and an additive effect on HCV RNA reduction in genotype 1 and 4 patients at 600 and 1,000 mg/day when combined with PEG IFN‐α2a. (HEPATOLOGY 2009.)
Elimination of junk document surrogate candidates through pattern recognition

A surrogate is an object that stands for a document and enables navigation to that document. Hypermedia is often represented with textual surrogates, even though studies have shown that image and text surrogates facilitate the formation of mental models and overall understanding. Surrogates may be formed by breaking a document down into a set of smaller elements, each of which is a surrogate candidate. While processing these surrogate candidates from an HTML document, relevant information may appear together with less useful junk material, such as navigation bars and advertisements. This paper develops a pattern recognition based approach for eliminating junk while building the set of surrogate candidates. The approach defines features on candidate elements, and uses classification algorithms to make selection decisions based on these features. For the purpose of defining features in surrogate candidates, we introduce the Document Surrogate Model (DSM), a streamlined Document Object Model (DOM)-like representation of semantic structure. Using a quadratic classifier, we were able to eliminate junk surrogate candidates with an average classification rate of 80%. By using this technique, semiautonomous agents can be developed to more effectively generate surrogate collections for users. We end by describing a new approach for hypermedia and the semantic web, which uses the DSM to define value-added surrogates for a document.
A Novel Low Cost Planar RFID Miniature Antenna

This paper presents a new miniature low cost planar RFID antenna designed @ 2.45 GHz. In order to validate the final structure, we have conducted a study on two antenna structures. The first one is based on a rectangular patch with a centred slot line, and the second one is based on a monopole antenna. By comparing the performances of both structures we have chosen the second one because due to the fact that presents a miniature d imensions and especially due to their compactness and robustness against the mechanical tolerances. The antenna achieved and measured demonstrates a good agreement between simulat ion and measurement results. Moreover, for imp roving the matching input impedance of the antenna, we have studied and optimized all geo metry dimensions of the whole structure. For the feed line we have used a CPW feed wh ich permits to integrate this antenna easily with the memo ry circuit to fo rm a tag system.
The Development and Validation of an Implicit Measure Based on Biospheric Values

Explicit measures of environmental views can be affected by social desirability and cognitive biases. Implicit measures, which should avoid such issues, have previously faced difficulty in establishing balanced and representative stimuli. Recently, measuring environmental views has shifted toward using environmental values, rather than attitudes. Accordingly, this article outlines a novel approach to implicit measures of environmental views using the Implicit Association Task (IAT). Stimuli representing Egoistic and Biospheric value orientations were selected, having positive valence and categorical representation. Across three independent samples (total N = 293), this Environment IAT (a) showed expected positive correlations with explicit measures of environmental values and attitudes, (b) reflected significant differences between environmentalists and non-environmentalists, and (c) was a unique predictor of environmentalist status even after controlling for explicit values and attitudes. Implications of the Environment IAT suggest a new research approach to environmental preferences for predicting behavior, and the automatic formation of attitudes.
Tyrosine Kinase Activity of Epidermal Growth Factor Receptor Is Regulated by GM3 Binding through Carbohydrate to Carbohydrate Interactions*

Epidermal growth factor receptor (EGFR), an N-glycosylated transmembrane protein with an intracellular kinase domain, undergoes dimerization by ligand binding resulting in activation of the kinase domain and phosphorylation. Ganglioside GM3 containing sialyllactose inhibits the tyrosine kinase activity of EGFR through carbohydrate to carbohydrate interactions (CCI) between N-glycans with GlcNAc termini on EGFR and oligosaccharides on GM3. In this study, we provide further evidence for CCI between EGFR and GM3. (i) In vitro and in situ, the inhibitory effect of GM3 on EGFR tyrosine kinase was much higher in A431 cells upon exposure of the GlcNAc termini of the N-glycans to glycosidase treatment (neuraminidase and β-galactosidase) than in untreated A431 cells. Furthermore, the GM3-mediated inhibition was abrogated by co-incubation with N-glycan containing terminal GlcNAc. (ii) In situ, inhibition of EGFR phosphorylation by GM3 was not observed in α-mannosidase IB (ManIB)-knocked down A431 cells that accumulate high mannose-type N-glycans. (iii) EGFR binding to GM3 was enhanced in glycosidase-treated cells that accumulated GlcNAc termini, whereas GM3 did not bind to EGFR from ManIB-knocked down cells that accumulated high mannose-type N-glycans. These results indicate that GM3-mediated inhibition of EGFR phosphorylation is caused by interaction of GM3 with GlcNAc-terminated N-glycan on EGFR.
Coarse Particulate Air Pollution Associated with Increased Risk of Hospital Admissions for Respiratory Diseases in a Tropical City, Kaohsiung, Taiwan

This study was undertaken to determine whether there was an association between coarse particles (PM2.5–10) levels and frequency of hospital admissions for respiratory diseases (RD) in Kaohsiung, Taiwan. Hospital admissions for RD including chronic obstructive pulmonary disease (COPD), asthma, and pneumonia, and ambient air pollution data levels for Kaohsiung were obtained for the period from 2006 to 2010. The relative risk of hospital admissions for RD was estimated using a case-crossover approach, controlling for weather variables, day of the week, seasonality, and long-term time trends. For the single pollutant model (without adjustment for other pollutants), increased rate of admissions for RD were significantly associated with higher coarse PM levels only on cool days (<25 °C), with a 10 µg/m3 elevation in PM2.5–10 concentrations associated with a 3% (95% CI = 1%–5%) rise in COPD admissions, 4% (95% CI = 1%–7%) increase in asthma admissions, and 3% (95% CI = 2%–4%) rise in pneumonia admissions. No significant associations were found between coarse particle levels and the number of hospital admissions for RD on warm days. In the two-pollutant models, PM2.5–10 levels remained significantly correlated with higher rate of RD admissions even controlling for sulfur dioxide, nitrogen dioxide, carbon monoxide, or ozone on cool days. This study provides evidence that higher levels of PM2.5–10 enhance the risk of hospital admissions for RD on cool days.
Interference With Peroxisome Proliferator-Activated Receptor-&ggr; in Vascular Smooth Muscle Causes Baroreflex Impairment and Autonomic Dysfunction

S-P467L mice expressing dominant negative peroxisome proliferator-activated receptor-&ggr; selectively in vascular smooth muscle exhibit impaired vasodilation, augmented vasoconstriction, hypertension, and tachycardia. We hypothesized that tachycardia in S-P467L mice is a result of baroreflex dysfunction. S-P467L mice displayed increased sympathetic traffic to the heart and decreased baroreflex gain and effectiveness. Carotid arteries exhibited inward remodeling but no changes in distensibility or stress/strain. Aortic depressor nerve activity in response to increased arterial pressure was blunted in S-P467L mice. However, the arterial pressure and heart rate responses to aortic depressor nerve stimulation were unaltered in S-P467L mice, suggesting that the central and efferent limbs of the baroreflex arc remain intact. There was no transgene expression in nodose ganglion and no change in expression of the acid-sensing ion channel-2 or -3 in nodose ganglion. There was a trend toward decreased expression of transient receptor potential vanilloid-1 receptor mRNA in nodose ganglion, but no difference in the immunochemical staining of transient receptor potential vanilloid-1 receptor in the termination area of the left aortic depressor nerve in S-P467L mice. Although there was no difference in the maximal calcium response to capsaicin in cultured nodose neurons from S-P467L mice, there was decreased desensitization of transient receptor potential vanilloid-1 receptor channels. In conclusion, S-P467L mice exhibit baroreflex dysfunction because of a defect in the afferent limb of the baroreflex arc caused by impaired vascular function, altered vascular structure, or compromised neurovascular coupling. These findings implicate vascular smooth muscle peroxisome proliferator activated receptor-&ggr; as a critical determinant of neurovascular signaling.
Interactive Discovery of Coordinated Relationship Chains with Maximum Entropy Models

Modern visual analytic tools promote human-in-the-loop analysis but are limited in their ability to direct the user toward interesting and promising directions of study. This problem is especially acute when the analysis task is exploratory in nature, e.g., the discovery of potentially coordinated relationships in massive text datasets. Such tasks are very common in domains like intelligence analysis and security forensics where the goal is to uncover surprising coalitions bridging multiple types of relations. We introduce new maximum entropy models to discover surprising chains of relationships leveraging count data about entity occurrences in documents. These models are embedded in a visual analytic system called MERCER (Maximum Entropy Relational Chain ExploRer) that treats relationship bundles as first class objects and directs the user toward promising lines of inquiry. We demonstrate how user input can judiciously direct analysis toward valid conclusions, whereas a purely algorithmic approach could be led astray. Experimental results on both synthetic and real datasets from the intelligence community are presented.
A sister of NANOG regulates genes expressed in pre-implantation human development

The NANOG homeobox gene plays a pivotal role in self-renewal and maintenance of pluripotency in human, mouse and other vertebrate embryonic stem cells, and in pluripotent cells of the blastocyst inner cell mass. There is a poorly studied and atypical homeobox locus close to the Nanog gene in some mammals which could conceivably be a cryptic paralogue of NANOG, even though the loci share only 20% homeodomain identity. Here we argue that this gene, NANOGNB (NANOG Neighbour), is an extremely divergent duplicate of NANOG that underwent radical sequence change in the mammalian lineage. Like NANOG, the NANOGNB gene is expressed in pre-implantation embryos of human and cow; unlike NANOG, NANOGNB expression is restricted to 8-cell and morula stages, preceding blastocyst formation. When expressed ectopically in adult cells, human NANOGNB elicits gene expression changes, including downregulation of a set of genes that have an expression pulse at the 8-cell stage of pre-implantation development. We conclude that gene duplication and massive sequence divergence in mammals generated a novel homeobox gene that acquired new developmental roles complementary to those of Nanog.
Is Sustainable Intensification Pro-Poor? Evidence from Small-Scale Farmers in Rural Tanzania

The transition of farming systems to higher levels of productivity without overusing natural resources is of rising interest especially in African countries, where population growth has often been larger than past productivity increases. This paper aims to contribute to the debate on whether environmentally friendly agricultural practices are compatible with economic interests. In the context of small-scale farm households in Tanzania, the analysis focuses on Conservation Agriculture (CA) at different levels of agricultural output, as CA is a promising toolbox for sustainable intensification. The results are based on a household survey conducted in 2014 with 900 randomly selected small-scale farmers in rural Tanzania, i.e., in semi-arid Dodoma and in semi-humid Morogoro region. We find that mulching is most frequently applied, followed by crop rotation, fallowing, intercropping and tree planting. Logit regressions show that CA adoption is influenced by socio-economic factors, farm characteristics and the regional context. Quantile regressions explain different levels of agricultural output through variables related to the extent of using CA. They indicate that marginalized farmers have the strongest crop income effect from an increased use of mulching. With increasing levels of agricultural output, the use of mulching remains beneficial for farmers, but the effect appears less pronounced.
Malaria Knowledge, Concern, Land Management, and Protection Practices among Land Owners and/or Managers in Lowland versus Highland Ecuador

To control malaria effectively, it is essential to understand the current knowledge, beliefs, concerns, land management practices, and mosquito bite protection methods in use by citizens. This study presents a comparative, quantitative, interview-based study of land owners and/or managers (n = 262) in the Ecuadorian lowlands (presently considered malarious) (n = 131) and highlands (potentially malarious in the future) (n = 131). Although respondents had a strong understanding of where the disease occurs in their own country and of the basic relationship among standing water, mosquitoes, and malaria, about half of respondents in potential risk areas denied the current possibility of malaria infection on their own property. As well, about half of respondents with potential anopheline larval habitat did not report its presence, likely due to a highly specific definition of suitable mosquito habitat. Most respondents who are considered at risk of malaria currently use at least one type of mosquito bite prevention, most commonly bed nets.
1H MR Spectrscopy and Chemical Shift Imaging of the In Vivo Brain at 7 Tesla

Neurotransmitters and compounds of the brain’s energy metabolism are directly linked to brain function. In vivo magnetic resonance (MR) spectroscopy is a useful method to quantify the neurochemical profiles of localized brain regions noninvasively and to provide valuable information for medical treatment or for the study of underlying mechanisms. The concentrations of substances in the brain detectable by MR, however, are at best in the range of millimols and the sensitivity of MR methods that are based on the Boltzmann spin polarization is inherently low. Most anatomical or functional structures in the brain of humans and monkeys are in the millimeter range or below. The spatial resolution that would be necessary to account for the small target dimensions could not be realized so far in humans and with current MR systems. Reasonable signal strength could only be achieved at the cost of limited spatial specificity. The spectral quality of in vivo MR spectroscopy and the amount of information available from it strongly depend on the existence and strength of potential experimental artifacts like frequency drifts, localization errors or spectral contaminations. In addition, the homogeneity of the magnetic field within the sensitive probe volume is a critical issue. The goal of the thesis was to establish different methods for MR spectroscopy and chemical shift imaging at maximum spatial specificity and spectral quality. The methods were to be adopted for investigations of the non-human primate visual cortex, an area of intense study of the brain’s physiology and function. To maximize the sensitivity and the quality of the MR spectra, a number of methods have been implemented and optimized. Artifact sources were analyzed and methodological corrections were proposed to overcome them. For instance, strong limitations of the MR scanner’s built-in capacity to compensate actively for inhomogeneities of the magnetic field by electrical coils were overcome by newly designed
Characterization of an extracellular metalloprotease with elastase activity from Staphylococcus epidermidis

The gene sepA from Staphylococcus epidermidis TU3298-P, encoding the extracellular neutral metalloprotease SepP1, was cloned into pT181mcs. DNA sequencing revealed an open reading frame of 1,521 nucleotides encoding a 507-amino-acid protein with an M(r) of 55,819. The sepA-containing DNA fragment did not hybridize with Staphylococcus hyicus or Staphylococcus carnosus DNA. Expression of sepA in the protease-negative S. carnosus (pT181mcsP1) resulted in overproduction of a 33-kDa protease found in the culture medium. The first 15 N-terminal amino acids of the partially purified protease completely matched the deduced DNA sequence starting at GCA (Ala-208). This finding indicated that SepP1 is synthesized as a preproenzyme with a 28-amino-acid signal peptide, a 179-amino-acid hydrophilic pro region, and a 300-amino-acid extracellular mature form with a calculated M(r) of 32,739. In activity staining, the mature protease prepared from S. carnosus (pT181mcsP1) corresponded to the extracellular S. epidermidis Tü3298-P protease. The partially purified protease had a pH optimum between 5 and 7, and its activity could be inhibited by zinc- and metal-specific inhibitors such as EDTA and 1,10-phenanthroline, indicating that it is a neutral metalloprotease. The protease had a low substrate specificity. Glucagon was cleaved preferentially between aromatic (Phe) and hydrophobic (Val) amino acids. The protease hydrolyzed casein and elastin. The amino acid sequence of the mature form of SepP1 revealed pronounced similarities with the thermolabile and thermostable neutral proteases of various bacilli (44 to 55% identity) and a central part of the mature form of the Pseudomonas aeruginosa elastase (31% identity). From homology comparison with the Bacillus thermoproteolyticus thermolysin, we predict that mature SepP1 binds one zinc ion at a conserved zinc-binding site.