Miracle-dz/UniFAR-FTUs huggingface dataset:
Younger Women with Lipedema, Their Experiences with Healthcare Providers, and the Importance of Social Support and Belonging: A Qualitative Study

Lipedema is a chronic adipose tissue disorder affecting approximately 11% of women worldwide. The illness is often misdiagnosed as obesity, and because of this, women often struggle in meetings with healthcare providers. Few studies have assessed these encounters of younger women with lipedema. The aims of this qualitative study were to explore women’s experiences in meetings with healthcare providers and the importance of social support and belonging, with a focus on younger women. Fifteen women with lipedema between the ages of 21 and 47 years (mean age 36.2 years) were interviewed. The results indicated that women felt stigmatized by healthcare providers and that younger women in their 20s and early 30s struggled more often than women of higher age when receiving their diagnosis. The feeling of shame and stigma were also dependent on the woman’s resources in handling the illness. The younger women reported that their self-confidence and romantic relationships were challenging. Social support and the feeling of belonging through romantic relationships or support groups were important resources for managing the illness. Highlighting the experiences of women may aid in increasing recognition and knowledge of lipedema. This in turn may reduce the stigma and lead to equitable healthcare services.
Quantum Efficiency of InP/InGaAs Uni-Traveling-Carrier Photodiodes at 1.55–1.7 µm Measured Using Supercontinuum Generation in Optical Fiber

The input wavelength dependence of the external quantum efficiency for InP/InGaAs uni-traveling-carrier photodiodes (UTC-PDs) was examined. A supercontinuum generated in the optical fiber was used as the monochromatic optical source with the wavelength ranging from 1.55 to 1.7 µm. The observed flatness of the efficiency shows the applicability of UTC-PDs to wide bandwidth transmission systems in which the bandwidths of the optical fiber and amplifier are fully utilized. It was also found that a UTC-PD with an acceptor doping density of 2.5×1018 cm-3 in the photo-absorption layer has a larger external quantum efficiency than a UTC-PD with a lower doping density at a wavelength around 1.7 µm. The mechanism of this enhancement is discussed based on the absorption coefficient and pulse responses measured at various input wavelengths.
All together now: Geographically coordinated miticide treatment benefits honey bee health

Abstract Deformed wing virus (DWV) is a pathogenic virus of honey bees transmitted by the ectoparasitic mite Varroa destructor. Annual overwintering colony losses, accounting for ~25% of all colonies, are associated with high levels of Varroa‐DWV infestation. Effective miticide treatments are available to control Varroa. However, the absence of coordinated treatment means environmental transmission of mites continues unchecked. We aimed to determine whether rational, coordinated treatment is beneficial, and characterized the DWV population as an indicator of colony health. This study uses coordinated treatment of Varroa in a geographically isolated environment (Isle of Arran, Scotland) over 3 years. The study area contained 50–84 colonies managed by ~20 amateur beekeepers. Sampling and virus analysis to assess strain diversity and viral loads were conducted before and after treatments, and changes in population diversity were quantified by sequence analysis. Over the 3 years analysis of the virus population revealed that the dominant DWV variant shifted from Type A to Type B in all apiaries, regardless of mite levels or proximity to other colonies. During this period the number of managed colonies increased by 47% (57–84 colonies), but despite this, we estimate total mite numbers decreased by 58%. Synthesis and applications. In this study, the beekeepers in Arran significantly improved the number of colonies they managed, without importing any bees onto the island, indicating that an improved focus on management techniques, through the combination of a coordinated miticide programme and an improved understanding of bee diseases, could yield positive results for bee health and sustainability.
RRL OBSERVATIONS USING ORT AT 328 MHz AND WSRT AT 1.4 GHz FROM ELDWIM

Radio recombination line (RRL or RL for short) observations from 10 Galactic positions using the Ooty Radio Telescope (ORT) at 328 MHz and the Westerbork Synthesis Radio Telescope (WSRT) at 1.4 GHz have been presented. ORT observations were made using a recently augmented New Digital Backend (NDB). NDB offered a bandwidth of 1 MHz that was used to observe H271α RL. The eight intermediate-frequency bands offered by WSRT in the incoherent addition mode were used to detect the seven H/Henα RLs with n = 165–171 and the H208β RL. RL observations common to WSRT and ORT have been put together to model the diffuse low-density ionized gas (extended low density warm ionized medium, ELDWIM). This modeling constrains the electron number density in ELDWIM to 1.0 cm−3 < ne < 10.0 cm−3 for a temperature range of 103–104 K for these 10 positions. An effective stellar temperature of the H ii region picture for three positions showing He line detection has been presented using spherical cloud modeling. The lower limits on the stellar temperatures are >33,000 K for the obtained ratios of NHe +/NH + toward these directions.
Boosting Photo Upconversion in Electropolymerised Thin Film with Yb/Er Complexes

Upconversion luminescence (UCL) in organometallic complexes has attracted great interest in photovoltaics and biological applications due to their fascinating energy transfer mechanism from low‐energy photon to high‐energy photon. However, photon‐upconversion operating in a single discrete entity remains a challenge caused by low‐absorption cross section of the luminescent lanthanide element. Here, a novel upconversion system is reported combining Yb (Ytterbium) sensitizers and Er (Erbium) activators in the film by electropolymerization, which leads to excited‐state absorption (ESA) and energy transfer upconversion (ETU) processes. For the first time, the UCL has been achieved in the thin films upon near‐infrared laser irradiation, and the upconversion intensity exhibits up to 30‐fold enhancement with the variation of Yb/Er ratio.
Design, Synthesis, and Biological Evaluation of 3-Substituted-Indolin-2-One Derivatives as Potent Anti-Inflammatory Agents

This study aimed to synthesize and evaluate the anti-inflammatory activity of 3-substituted-indolin-2-one derivatives. Cell viability of 3-substituted-indolin-2-one derivatives was measured with the EZ-Cytox reagent; interleukin (IL)-6, tumor necrosis factor (TNF)-α, and inducible NOS mRNA levels were measured using Taqman qRT-PCR; pro-inflammatory cytokine IL-6 and TNF-α levels were determined using ELISA kits; the phosphorylation of Akt, JNK, ERK, p38, p65, and IκB protein levels were measured by immunoblotting. Among the nineteen 3-substituted-indolin-2-one derivatives synthesized, 3-(3-hydroxyphenyl)-indolin-2-one showed the highest anti-inflammatory activity, inhibiting the nitric oxide production related to inflammation, suppressing the production of TNF-α and IL-6 in a concentration-dependent manner and mRNA expression. Moreover, 3-(3-hydroxyphenyl)-indolin-2-one significantly inhibited lipopolysaccharide (LPS)-induced signal pathways such as the Akt, MAPK, and NF-κB signaling pathways. Our findings revealed that a 3-substituted-indolin-2-one derivative, 3-(3-hydroxyphenyl)-indolin-2-one, possesses excellent anti-inflammatory activity and can be considered for future research.
Overview of Sigma-1R Subcellular Specific Biological Functions and Role in Neuroprotection

For the past several years, fundamental research on Sigma-1R (S1R) protein has unveiled its necessity for maintaining proper cellular homeostasis through modulation of calcium and lipid exchange between the endoplasmic reticulum (ER) and mitochondria, ER-stress response, and many other mechanisms. Most of these processes, such as ER-stress response and autophagy, have been associated with neuroprotective roles. In fact, improving these mechanisms using S1R agonists was beneficial in several brain disorders including neurodegenerative diseases. In this review, we will examine S1R subcellular localization and describe S1R-associated biological activity within these specific compartments, i.e., the Mitochondrion-Associated ER Membrane (MAM), ER–Lipid Droplet (ER–LD) interface, ER–Plasma Membreane (ER–PM) interface, and the Nuclear Envelope (NE). We also discussed how the dysregulation of these pathways contributes to neurodegenerative diseases, while highlighting the cellular mechanisms and key binding partners engaged in these processes.
Efficiency of conditional maximum likelihood estimators and confidence limits for mixtures of exponential families

SUMMARY In a previous paper (Basawa, 1981) efficient conditional tests were discussed for mixture experiments involving dependent observations. The present paper is devoted to a study of the performance, in large samples, of a conditional maximum likelihood estimator and of a confidence limit for a parameter in a model specified by a mixture of a two-parameter exponential family. The conditional estimator proposed in the paper is free from the mixing distribution, and is efficient for all reasonable mixing distributions.
Simulation of three-dimensional optical waveguides by a full-vector beam propagation method

Simulations of optical guided waves in three-dimensional waveguide structures by a full vector beam propagation method are described. Two sets of coupled equations governing the propagation of the transverse electric and magnetic fields are derived systematically. Polarization dependence and coupling due to the vectorial nature of the electromagnetic fields are considered in the formulations. The governing equations are solved subsequently by finite-difference schemes. The vector BPM is first assessed for a step-index circular fiber by comparing the numerical results with the exact analytical solutions. The guided modes of a rib waveguide are then investigated in detail. Comparisons among the scalar, semi-vector and full-vector simulations of the rib waveguide are made. Finally polarization rotation of a periodically loaded rib waveguide operated fully based on the vector nature of the electromagnetic waves is modeled and simulated. >
Performance Characteristics of Electrohydrodynamic Conduction Pump in Two-Phase Loops

The electric field applied in dielectric fluids causes an imbalance in the dissociation-recombination reaction generating free space charges. The generated charges are redistributed by the applied electric field resulting in the heterocharge layers in the vicinity of the electrodes. Proper design of the electrodes generates net axial flow motion pumping the fluid. The electrohydrodynamic (EHD) conduction pump is a new device that pumps dielectric fluids utilizing heterocharge layers formed by imposition of electrostatic fields. This paper investigates the performance characteristics of EHD conduction pump in two-phase thermal control loops. The EHD twophase loop consists of an EHD conduction pump, condenser, evaporator, transport lines, and reservoir (accumulator). The tests are performed with two different loops alternating two different EHD pumps to measure the generated pressure head and the mass flowrate at various applied voltages and sink temperatures. The power consumption of EHD conduction pumps is also determined by measuring the electric current value. The de-aerated R134a and unprocessed R134a are used as the working fluid. The dependence of EHD pump performance on the fluid temperature, effects of de-aeration of working fluid, effects of electrode design, pressure loss within EHD pump, influence of the loop size (tube diameter and length) are investigated.
Fruit Image Classification Model Based on MobileNetV2 with Deep Transfer Learning Technique

Due to the rapid emergence and evolution of AI applications, the utilization of smart imaging devices has increased significantly. Researchers have started using deep learning models, such as CNN, for image classification. Unlike the traditional models, which require a lot of features to perform well, CNN does not require any handcrafted features to perform well. It uses numerous filters, which extract required features from images automatically for classification. One of the issues in the horticulture industry is fruit classification, which requires an expert with a lot of experience. To overcome this issue an automated system is required which can classify different types of fruits without the need for any human effort. In this study, a dataset of a total of 26,149 images of 40 different types of fruits was used for experimentation. The training and test set were randomly recreated and divided into the ratio of 3:1. The experiment introduces a customized head of five different layers into MobileNetV2 architecture. The classification layer of the MobileNetV2 model is replaced by the customized head, which produced the modified version of MobileNetV2 called TL-MobileNetV2. In addition, transfer learning is used to retain the pre-trained model. TL-MobileNetV2 achieves an accuracy of 99%, which is 3% higher than MobileNetV2, and the equal error rate of TL-MobileNetV2 is just 1%. Compared to AlexNet, VGG16, InceptionV3, and ResNet, the accuracy is better by 8, 11, 6, and 10%, respectively. Furthermore, the TL-MobileNetV2 model obtained 99% precision, 99% for recall, and a 99% F1-score. It can be concluded that transfer learning plays a big part in achieving better results, and the dropout technique helps to reduce the overfitting in transfer learning.
Bifurcation and stability analyses for a two-phase Rayleigh–Benard problem in a cavity

Stability and bifurcation analyses of a partially melted or solidified material heated from below and cooled from above in a cavity, the so-called two-phase Rayleigh–Benard problem, are conducted by a finite-volume/Newton’s method. Bifurcation analysis techniques using a numerical Jacobian and an iterative matrix solver suitable to this large complicated system are adopted. The onset and evolution of melt flows coupling with the heat conduction in the solid and a deformable melt/solid interface are illustrated through detailed bifurcation diagrams, and the linear stability of each flow family is carefully examined. Some comparison with the one-phase system is performed. Results are presented for a variety of parameters of interest, including the Rayleigh number, aspect ratio, and tilt angle. Although most calculations are presented for the melt with a Prandtl number of one, the effects of Prandtl number on the onset of cellular convection and the sensitivity of symmetry breaking by tilting are examined. F.
High speed nanophotonic devices based on quantum dots

For InAs‐GaAs based quantum dot lasers emitting at 1300 nm digital modulation with bit error rates below 10–11 at –2 dBm receiver power is demonstrated. Error rates of 10–9 or better are realized between 23 °C and 70 °C without current adjustment. Passive and hybrid mode‐locked QD lasers are shown to generate optical pulses with repetition frequencies up to 80 GHz and 40 GHz, respectively, with an ultra‐short minimum pulse length of 710 fs at 20 GHz. The minimum root mean square jitter of 40 GHz hybrid mode‐locked pulses is found to be 400 fs with a corresponding pulse width of 4 ps.
Study of pulsatile flow in a porous annulus with the homotopy analysis method

Purpose – The purpose of this study is to investigate the problem of pulsatile flow in a porous annulus for small Reynolds number.Design/methodology/approach – The similarity transformation for the governing equations gives a system of nonlinear ordinary differential equations which are analytically solved by the homotopy analysis method (HAM). The analytic solutions of non‐linear differential equation are constructed in the series form. The convergence of the series solutions is carefully analyzed.Findings – Graphical results are presented to investigate the influence of different parameters on the flow behavior. Comparison between the solutions obtained by the HAM and the numerical solution shows good agreement.Originality/value – An analysis for study on flow of an incompressible viscous fluid in the region lying between two concentric porous cylinders, under the assumption that a periodic pressure gradient is imposed across the annulus and that there is a uniform small transfer across two walls is pre.
Effects of Two Different Straw Pellets on Yak Growth Performance and Ruminal Microbiota during Cold Season

Simple Summary The Tianzhu white yaks is a unique species living on the Qinghai–Tibet Plateau and has strong adaptability to high altitude and low oxygen. These yaks mainly rely on natural pasture as the source of nutrients. However, because of low temperature and insufficient pasture in winter, the Tianzhu white yak lose weight. The ruminal microbiota of yaks can efficiently acidify and hydrolyze fiber to produce volatile fatty acids (VFAs). In this study, we investigated how the ruminal microbiota affects the growth performance of yaks after supplementing straw feed and assessed the changes in ruminal microbiota and VFAs. Correlation analysis revealed a correlation among the ruminal microbiota, VFAs, and daily weight gain (ADG) of yaks. Mainly, the abundance of cellulose bacteria that can hydrolyze straw feed increased to produce more levels of VFAs, which were absorbed by the yaks, increasing their ADG. Abstract The Tianzhu white yaks (Bos grunniens) live on the Qinghai–Tibet Plateau. During winter, a lack of resources and low nutritional levels seriously affect their growth performance. In this study, we aimed to explore the effect of supplementation straw pellets on the growth performance and ruminal microbiota of yaks. Overall, at 6 (6M, n = 24), 18 (18M, n = 26), 30 (30M, n = 20), 42 (42M, n = 24), and 54 (54M, n = 22) month old Tianzhu white yaks were selected (total n = 116) and divided into the mixed straw + grazing (MSG), corn straw + grazing (CSG), and the grazing control (G) groups according to age and gender. Their growth performance was measured as per different dietary treatments. The rumen microbial community structure and levels of VFAs were analyzed from the 6M, 30M, and 54M male yaks from each group. The supplementary diets led to an increase in the ADG, which was the highest in the MSG group. The MSG group exhibited the highest level of acetate and total VFAs (TVFAs) among the three groups (p < 0.05). In addition, the 16S rRNA sequencing results proved that the microbial composition was dominated by the members of Firmicutes and Bacteroidetes. Christensenellaceae R-7 group was significantly abundant in the CSG and MSG groups compared to the G group (p < 0.05). Principal coordinate analysis (PCoA) revealed that the bacterial community structure of rumen in the MSG and CSG groups was considerably different from that in the G group; 6M samples exhibited different rumen microbial diversity compared with the other samples. Correlation analysis revealed that Christensenellaceae_R-7_group was positively correlated with the levels of acetate, TVFAs, and ADG. These results demonstrated that mixed straw pellets improved the growth performance of yaks, increased the abundance of Christensenellaceae R-7_group involved in cellulose degradation in the rumen, and produced large amounts of VFAs, which were absorbed by yaks, thus increasing their ADG. This study provides new insights into the effects of straw pellet supplementation on the changes in the rumen microbiota and growth performance of yaks.
Time variability studies with photon-counting imaging detectors. I: A maximum likelihood technique

We present a new method for characterizing the variability properties of a preselected class of celestial objects which are repeatedly observed with the same photon-counting imaging detector. Instrument-specific characteristics, such as detector instrument point response function and mirror system off-axis response, are separated and taken into account in the form of input parameters. All collected source data, both in the form of detections and upper bounds at putative source positions, are retained and fully used in determining the maximum likelihood (ML) estimator of the instrinsic source count rate
CFD simulation of momentum injection control past a streamlined body

Purpose – The purpose of this paper is to achieve high‐performance aerofoils that enable delayed stall conditions and achieve high lift to drag ratios.Design/methodology/approach – The unsteady Reynolds averaged Navier‐Stokes equations are employed in conjunction with a shear stress transport (κ‐ω) turbulence model. A control equation is designed and implemented to determine the temporal response of the actuator. A rotating element, in the form of an actuator disc, is embedded on the leading edge of NACA 0012 aerofoil, to inject momentum into the wake region. The actuator disc is rotated at different angular speeds, for angles of attack (α) between 00 and 240.Findings – Phenomena such as flow separation, wake vortices, delayed stall, wake control, etc. are numerically investigated by means of streamlines, streaklines, isobars, etc. Streamwise and cross‐stream forces on the aerofoil are obtained. The influence of momentum injection parameter (ξ) on the fluid flow patterns, and hence on the forces acting on.
Fetal Ovarian Cyst—A Scoping Review of the Data from the Last 10 Years

Abdominal cystic masses are diagnosed during the intrauterine period and have a relatively low incidence. Fetal ovarian cysts are the most common form diagnosed prenatally or immediately after birth. The pathophysiology of the development of these types of tumors is not fully elucidated, with ovarian hyperstimulation caused by maternal and placental hormones being the most accepted hypothesis. During intrauterine development, the diagnosis of fetal ovarian cysts is most often made accidentally during usual check-up ultrasounds corresponding to the first, second, and third trimesters of pregnancy. We conducted a scoping review with the aim to map the current knowledge regarding the treatment of fetal ovarian cysts diagnosed in the intrauterine period. Focusing on the articles published in the last 10 years in the specialized literature, we tried to identify a conceptualization regarding the surveillance and treatment of these anomalies.
Relativistic fireballs: energy conversion and time-scales

The expansion energy of a relativistic fireball can be reconverted into radiation when it interacts with an external medium. For expansion with Lorentz factors greater than or approximately equal to 1000 into a typical galactic environment, the corresponding time-scale in the frame of the observer is of the order of seconds. This mechanism would operate in any cosmological scenario of gamma-ray bursts involving initial energies of order a percent of a stellar rest mass, and implies photon energies and time-scales compatible with those observed in gamma-ray bursts.
The nonlinear interactor and its application to input-output decoupling

The solvability of the input-output decoupling problem via pure dynamic state feedback, a special type of dynamic compensator without zeros at infinity, is investigated. A necessary and sufficient condition for the solvability of this problem is established in terms of a nonlinear interactor, a new concept in the theory of nonlinear control. >