Miracle-dz/UniFAR-FTUs huggingface dataset:
Articulation, service use, managing and coping: understanding the needs of older people and carers living with dementia

Background: There is increasing recognition of the need to involve people living with dementia in research that can impact on service developments in the field. Despite this, people with dementia are still under-represented and proxy/carer views have dominated discourses of care. For nursing, understanding the views and experiences of people living with dementia is particularly important for the development of effective person-centred practices. Aim and objectives: The aims of the research were to identify: •The conditions that enable people living with dementia to participate effectively in decision making about the use and uptake of services •The factors that affect access, uptake and use of care services for people living with dementia and their supporters Methods: A participatory and constructivist methodology guided the study; consistent with this, a mixed qualitative method approach was used to gather data. Participatory observation was used to identify key issues and key participants (four people living with dementia and four carers), who were then interviewed. The interview data were analysed using the constructivist data analysis processes of unitising and categorising. Findings: Three main themes were identified from the interview data; barriers to articulation of experiences; finding help and support; and managing and coping. The impact of these issues on the choice and decision-making processes of people living with dementia and their carers emerged in a range of ways and are presented here.
Lamellar-Grating-Based MEMS Fourier Transform Spectrometer

Design, fabrication, and characterization of a high-performance micromachined lamellar-grating-interferometer-based Fourier transform spectrometer are presented. The device is designed to give high deflections with very low dynamic deformation and good mode separation. Mechanical self-stoppers are introduced to withstand accelerations larger than 500 g due to shock. The clear aperture area of the grating is about 10 mm2. The maximum deflection while electrostatically actuated at ambient conditions is ±356 μm at 71.2 V and 340 Hz, setting a record for comparable devices. At a pressure of 8.6 Pa, the same deflection is reached at 4.3 V. Six hundred eighty spectra per second can be recorded with a resolution of 14 cm-1. With a HeNe laser at 633 nm, a spectral resolution of 0.54 nm (22 cm-1) is reached using electrostatic actuation. The microelectromechanical systems device is integrated into a compact Fourier transform spectrometer setup including a blackbody source, an infrared (IR) detector, and a visible laser using the device back side for reference. Early results with IR interferograms are also reported. In addition, the devices are actuated with pressure waves in the ambient air to reach deflections up to ±700 μm. With this setup, the spectrum of a red laser is measured with a resolution of 0.3 nm (12.4 cm-1).
Biochemical quantification of triamcinolone in subconjunctival depots.

OBJECTIVE To biochemically quantify the amount of active triamcinolone acetonide remaining after subconjunctival administration and to assess the effectiveness of surgical management for glaucoma induced by triamcinolone. DESIGN Case series. PARTICIPANTS Seven eyes of seven patients whose ages ranged from 47 to 84 years underwent excision of depot triamcinolone. Six of seven eyes required surgical intervention for medically unresponsive intraocular pressure (IOP) elevation. RESULTS Pharmacologically active triamcinolone was identified up to 13 months following injection (range, 3 to 13 months). The mean amount in the excised sample was 5.4 mg (range, 2.0 to 8.8 mg), and the mean percentage of the original sample remaining was 20% (range, 4.2% to 44%). Glaucoma was diagnosed a mean of 3 months after injection (range, 1 to 6 months). Mean IOP was 37 mm Hg before excision and 16 mm Hg after removal. Surgical excision of visible triamcinolone normalized IOP in six of seven patients without need for glaucoma medications. CONCLUSIONS Periocular injection of triamcinolone necessitates careful monitoring of IOP. Medically unresponsive IOP elevation may occur as late as 6 months following periocular triamcinolone injection. Surgical excision of remaining triamcinolone depot is an effective therapy for IOP elevation. Guidelines for safely using triamcinolone are discussed.
On the support of task-parallel algorithmic skeletons for multi-GPU computing

An emerging trend in the field of Graphics Processing Unit (GPU) computing is the harnessing of multiple devices to cope with scalability and performance requirements. However, multi-GPU execution adds new challenges to the already complex world of General Purpose computing on GPUs (GPGPU), such as the efficient problem decomposition, and dealing with device heterogeneity. To this extent, we propose the use of the Marrow algorithmic skeleton framework (ASkF) to abstract most of the details intrinsic to the programming of such platforms. To the best of our knowledge, Marrow is the first ASkF to support skeleton nesting on single and (now) multiple GPU systems. In this paper we present how it can transparently distribute the execution of skeleton compositions among a set of, possibly, heterogeneous devices. An experimental evaluation assesses the proposal's effectiveness, from a scalability and performance perspective, with good results.
Myosin-I moves actin filaments on a phospholipid substrate: implications for membrane targeting

Acanthamoeba myosin-I bound to substrates of nitrocellulose or planar lipid membranes on glass moved actin filaments at an average velocity of 0.2 micron/s. This movement required ATP and phosphorylation of the myosin-I heavy chain. We prepared planar lipid membranes on a glass support by passive fusion of lipid vesicles (Brian, A. A., and H. M. McConnell. 1984. Proc. Natl. Acad. Sci. USA. 81:6159-6163) composed of phosphatidylcholine and containing 0-40% phosphatidylserine. The mass of lipid that bound to the glass was the same for membranes of 2 and 20% phosphatidylserine in phosphatidylcholine and was sufficient to form a single bilayer. Myosin-I moved actin filaments on planar membranes of 5-40% but not 0-2% phosphatidylserine. At the low concentrations of phosphatidylserine, actin filaments tended to detach suggesting that less myosin-I was bound. We used the cooperative activation of Acanthamoeba myosin-I ATPase by low concentrations of actin to assess the association of phospholipids with myosin-I. Under conditions where activity depends on the binding of actin to the tail of myosin-I (Albanesi, J. P., H. Fujisaki, and E. D. Korn. 1985. J. Biol. Chem. 260:11174-11179), phospholipid vesicles with 5-40% phosphatidylserine inhibited ATPase activity. The motility and ATPase results demonstrate a specific interaction of the tail of myosin-I with physiological concentrations of phosphatidylserine. This interaction is sufficient to support motility and may provide a mechanism to target myosin-I to biological membranes.
Insider Trading, Secret Agents, Evidentiary Privileges, and the Production of Information

Most things are owned by someone. The owner makes decisions on the assumption that, if he can improve the use or productivity of the property, he may claim a substantial part of the benefits. Information, in contrast, usually is unowned; at least, it is not subject to the same rules of property law that govern apples and steel mills. It is difficult too, for someone who possesses information to appropriate the benefits of knowledge. Much of the value of information depends on its employment in transactions with third parties (whether strangers or employees) who may elect to use the knowledge for their own benefit later on.1 It is hard to detect a
Influence of Polymer Fiber on Strength of Concrete

This paper outlines an experimental study that measures the effects of polymer fiber on proprieties of concrete. However, polymer fiber may serve as a superplasticizer admixture which may result to concrete’s lower rate of water absorption, high-range water reducer, greater strength and excellent in elasticity. Hence, an experimental investigation was conducted to determine the optimum dosage for the admixtures and to study the effect of over dosage of the mentioned admixtures. This elastic property of the polymer fiber reinforced in cement-concrete mix may produce better earthquake resistance of the building or structure as it deflects for a while as the load is applied and then returns to its original position as the load is removed. The experiments made were concrete with polymer fiber (polyvinyl alcohol, polyvinyl acetate) as the experimental group and a standard concrete mix being the control group. Polymer fiber used has been dissolved in water with five different proportions ranging from 2% to 10% with respect to cement’s percent by weight in kg. This specimen is molded in a cylinder with constant volume of cement, sand and gravel at 1:2:4 mix proportion of class “A”. The specimens formed were cured and tested to compressive strength on the 7th, 14th and 28th days after curing. Results prove that concrete mix having polymer fiber gave greater strength results than the standard mix.
Adrenomedullin as an autocrine/paracrine apoptosis survival factor for rat endothelial cells.

Adrenomedullin is a potent vasorelaxant/hypotensive peptide recently isolated from human pheochromocytoma. We demonstrate here a novel role of this peptide as an apoptosis survival factor for rat endothelial cells. When rendered quiescent by serum deprivation, a fraction of endothelial cell cultures showed morphological and biochemical features characteristic of apoptosis. Adrenomedullin significantly suppressed apoptosis without inducing cell proliferation. Rat endothelial cells that contained high affinity binding sites for adrenomedullin expressed adrenomedullin gene and released the peptide into culture media. Addition of preimmune rabbit serum prevented apoptosis, whereas rabbit antiadrenomedullin antiserum partially, but significantly, abrogated the protective effect of the preimmune serum, suggesting its autocrine/paracrine role. Although adrenomedullin induced intracellular cAMP formation, other cAMP-elevating agonists, such as prostaglandin I2 and forskolin, did not affect apoptosis. Furthermore,.
Exploiting Secondary Sources for Automatic Object Consolidation

Information sources on the web are controlled by different organizations or people, utilize different text formats, and have varying inconsistencies. Therefore, any system that integrates information from different data sources must consolidate data from these sources. Data from many data sources on the web may not contain enough information to accurately consolidate the data even using state of the art object consolidation systems. We present an approach to accurately and automatically consolidate data from various data sources by utilizing a state of the art object consolidation system in conjunction with a mediator system. The mediator system is able to automatically determine which secondary sources need to be queried in cases where the object consolidation system is unable to confidently determine whether two records refer to the same entity. In turn, the object consolidation system is then able to utilize this additional information to improve the accuracy of the consolidation between datasets.
Estrogen and Progesterone Receptors as Prognostic Factors in Breast Cancer

The relation between estrogen receptors (ER) and/or progesterone receptors (PgR) and some clinical factors such as tumor size, axillary node involvement, histological tumor grade, and disease-free interval (DFI) in 500 patients with operable (TNM stage I-III) breast cancer was studied. ER-positive (ER+) tumors were commoner in older patients, whereas PgR-positive (PgR+) tumors were similarly distributed within the age groups. The concentration of ER+ protein also increased with age in contrast to PgR+ protein concentration. However, receptor status was not associated with menopausal status independently of age. Axillary node involvement influenced neither ER nor PgR status, but there was a statistically significant relation between tumor size and positivity of ER or PgR. There was no association between histologic tumor grade and either steroid receptor phenotype. DFI was longer in patients with ER+ than those with ER− tumors, independently of axillary nodal status. The positivity of PgR in patients with ER+ tumors contributed to an even longer DFI, suggesting that the combination of ER/PgR is a better indicator of DFI than ER or PgR alone.
Integrating games and machine learning in the undergraduate computer science classroom

A student will be more likely motivated to pursue a field of study if they encounter relevant and interesting challenges early in their studies. The authors are PIs on two NSF funded course curriculum development projects (CCLI). Each project seeks to provide compelling curricular modules for use in the Computer Science classroom starting as soon as CS 1. In this paper, we describe one curriculum module which is the synergistic result of these two projects. This module provides a series of challenges for undergraduate students by using a game environment to teach machine learning and classic Artificial Intelligence concepts.
Quality of diet and food choices of Finnish young men: a sociodemographic and health behaviour approach

Abstract Objective Eating habits of Finns have improved dramatically in 40 years. The proportion of fat in the diet has decreased and vegetable and fruit consumption increased. Knowledge of Finnish young men’s dietary habits is limited. The aim was to assess food choices and quality of diet among young men and to analyse how background and health behaviour factors explain it. Design In 2007, data on eating habits, sociodemographic background factors and health behaviours of 17–21-year-old men (n 2905) entering military service were collected by self-administrated questionnaire. Two indexes – core food index (CFI) and extra food index (EFI) – were formed to describe daily and redundant snacking-type eating, respectively. Associations of background factors and health behaviours on the indexes were analysed by general linear modelling. Results In all, 13 % consumed fruits and berries daily and 8 % consumed vegetables, whereas 24 % consumed pizza and 19 % consumed hamburgers more than once a week. CFI increased with educational level (P < 0·001) and was explained by background and health behaviour (smoking, physical activity and eating breakfast). EFI was inversely associated with BMI (P < 0·001) and explained by health behaviour: (smoking, physical activity, drinking beer and eating breakfast). Conclusions These results indicate that in early adulthood, eating habits cluster with other health behaviours among men. In this age group, education is associated with core food but not with extra food eating habits. Furthermore, seasonal variation is seen in both types of eating. When promoting healthy eating, a distinction between core foods and extra foods by using feasible indexes will be helpful in targeting the efforts.
Efficient isolation of HIV from plasma during different stages of HIV infection

Attempts to isolate human immunodeficiency virus (HIV) from blood plasma using inoculation of pellets from ultracentrifuged samples into cultures of peripheral blood mononuclear cells (PBMC) resulted in a high overall recovery rate (75%) of the virus from 76 patients in various stages of HIV infection. The recovery rate was dependent on the stage of infection; in patients with acquired immunodeficiency syndrome (AIDS) it was 100%, in AIDS‐related complex (ARC) 86%, in persistent generalized lymphadenopathy (PGL) 64%, and in asymptomatic patients 54%. The HIV isolation rates compared favorably with those obtained after cocultivation of patient and target PBMC (overall recovery rate 67%). HIV was isolated from plasma but not from PBMC in 8 cases, whereas the reverse was true in 3 of 71 simultaneously tested cases. Isolation from plasma was found to be superior to detection of serum p24 antigen for the demonstration of HIV (positivity rates 75% and 30%, respectively). The time to appearance of p24 antigen in cultures inoculated with HIV‐containing plasma samples was inversely related to the presence of detectable p24 antigen in serum. There was a significantly shorter time to culture positivity of plasma samples from AIDS and ARC patients than from PGL and asymptomatic patients. These results suggested that there is a progressive increase in the concentrations of infectious HIV in plasma from the asymptomatic to the AIDS stage.
Optimal-coherent and adaptive software defined inference of network traffics (OCcASION)

In this paper, the OCcASION framework for Traffic Matrix (TM) estimation in Software Defined Networks (SDN) is proposed where, first in the learning phase, the Optimal Observation Matrix (OOM) of SNMP link-loads is estimated. Then in the measurement and inference phase, the OOM is used to coherently find the minimum-norm estimate of the unknown TM. This framework is applied under both non-adaptive and adaptive scenarios. The performance of OCcASION framework is evaluated using synthetic and practical traffic traces with real network topologies. It is shown that, comparing with regular minimum-norm estimation, this framework can significantly improve the accuracy of the TM estimation; for example, on Geant network the estimation error is approximately reduced by 83%.
Ionic-liquid-based dispersive liquid-liquid microextraction combined with magnetic solid-phase extraction for the determination of aflatoxins B1 , B2 , G1 , and G2 in animal feeds by high-performance liquid chromatography with fluorescence detection.

A novel two-step extraction technique combining ionic-liquid-based dispersive liquid-liquid microextraction with magnetic solid-phase extraction was developed for the preconcentration and separation of aflatoxins in animal feedstuffs before high-performance liquid chromatography coupled with fluorescence detection. In this work, ionic liquid 1-octyl-3-methylimidazolium hexafluorophosphate was used as the extractant in dispersive liquid-liquid microextraction, and hydrophobic pelargonic acid modified Fe3 O4 magnetic nanoparticles as an efficient adsorbent were applied to retrieve the aflatoxins-containing ionic liquid. Notably, the target of magnetic nanoparticles was the ionic liquid rather than the aflatoxins. Because of the rapid mass transfer associated with the dispersive liquid-liquid microextraction and magnetic solid phase steps, fast extraction could be achieved. The main parameters affecting the extraction recoveries of aflatoxins were investigated and optimized. Under the optimum conditions, vortexing at 2500 rpm for 1 min in the dispersive liquid-liquid microextraction and magnetic solid-phase extraction and then desorption by sonication for 2 min with acetonitrile as eluent. The recoveries were 90.3-103.7% with relative standard deviations of 3.2-6.4%. Good linearity was observed with correlation coefficients ranged from 0.9986 to 0.9995. The detection limits were 0.632, 0.087, 0.422 and 0.146 ng/mL for aflatoxins B1 , B2, G1, and G2, respectively. The results were also compared with the pretreatment method carried out by conventional immunoaffinity columns.
An Exegesis of the Curation Concept

The concept of "curation" has enjoyed wide use but also has received sharp criticism in the past two decades. Ambiguity in original sources permits curation to signify variously the implications and consequences of one practice and the relationship that underlies it. As a result, curation means too many different things. A new definition involving utility extracted follows from the view that curation is a continuous, not nominal, variable and that it is a property of tools, not of entire assemblages or industries. So understood, the ambiguity and contested meanings plaguing the term may disappear.
Function approximation with spiked random networks

This paper examines the function approximation properties of the "random neural-network model" or GNN. The output of the GNN can be computed from the firing probabilities of selected neurons. We consider a feedforward Bipolar GNN (BGNN) model which has both "positive and negative neurons" in the output layer, and prove that the BGNN is a universal function approximator. Specifically, for any f is an element of C([0, 1]s) and any epsilon>0, we show that there exists a feedforward BGNN which approximates f uniformly with error less than epsilon. We also show that after some appropriate clamping operation on its output, the feedforward GNN is also a universal function approximator.
Precomputed Visibility Cuts for Interactive Relighting with Dynamic BRDFs

This paper presents a novel PRT-based method that uses precomputed visibility cuts for interactive relighting with all-frequency environment maps and arbitrary dynamic BRDFs. Our method is inspired by the recent Lightcuts approach [24] and we parameterize distant environment lighting onto uniformly distributed sample points over the sphere. Using a binary tree structure of the points, we precompute and approximate each vertex's visibility function into clusters that we call the precomputed visibility cuts. These cuts are iteratively selected with bounded approximation error and confined cluster size. At run-time, a GPU-based relighting algorithm quickly computes the view-dependent shading color by accessing a dynamically built light tree, the precomputed visibility cuts, and a direct sampling of an arbitrary BRDF using each visibility cluster's average direction and the dynamic view direction. Compared to existing PRT techniques, our method guarantees uniform sampling of the lighting, requires no precomputed BRDF data, and can be easily extended to handle one-bounce glossy indirect transfer effects in real-time.
In Vivo Selective Measurement of {1−13C}‐Glucose Metabolism in Tumors by Heteronuclear Cross Polarization

Selective detection of {1−13C}‐glucose and its glycolytic product, {3−13C}‐lactate, was achieved by selective 13C NMR spectroscopy with 1H cross polarization. The total sensitivity of conventional broadband experiments was retained, and peak intensities were at least equivalent to those obtained with the inverse detection technique (i.e., 1H{13C}) for single proton resonances. A key advantage of the method is that it maintains the specific absorption rate (SAR) within FDA limits of 5 W/kg by reducing power deposition during decoupling. In this study we have monitored the kinetics of metabolism of 13C‐labeled glucose to lactate following intravenous infusion of 0.55 ml of 0.18 M labeled glucose. Physiological effects were minimized by a) maintaining total plasma glucose concentrations below 20 mM throughout the course of NMR experiment and b) by avoiding significant heating of the tumor.
Suicide and the right to die

New and old factors in suicide / Patrick Baudry -- Sociological approach to suicide, from Durkheim to the present day / Patrick Baudry -- Psychology of suicide / Heinz Henseler -- Respecting life and causing death in the medical context / Lisa Sowle Cahill -- Ethical arguments in favour of suicide / Annemarie Pieper -- Associations for the right to die in dignity / Paula Caucanas-Pisier -- Church's traditional moral teaching on suicide / Niceto Blazquez -- Funeral rights for a suicide and liturgical developments / David Power -- "Life no longer has any meaning for me" / Jean-Pierre Jossua -- Right to a freely chosen death? / Adrian Holderegger -- Have Christians the right to kill themselves? / Harry Kuitert.