Miracle-dz/UniFAR-FTUs huggingface dataset:
Coevolution of Hydrological Cycle Components under Climate Change: The Case of the Garonne River in France

Climate change is suspected to impact water circulation within the hydrological cycle at catchment scale. A SWAT model approach to assess the evolution of the many hydrological components of the Garonne catchment (Southern France) is deployed in this study. Performance over the calibration period (2000–2010) are satisfactory, with Nash–Sutcliffe ranging from 0.55 to 0.94 or R2 from 0.86 to 0.98. Similar performance values are obtained in validation (1962–2000). Water cycle is first analyzed based on past observed climatic data (1962–2010) to understand its variations and geographical spread. Comparison is then conducted against the different trends obtained from a climate ensemble over 2010–2050. Results show a strong impact on green water, such as a reduction of the soil water content (SWC) and a substantial increase in evapotranspiration (ET) in winter. In summer, however, some part of the watershed faces lower ET fluxes because of a lack of SWC to answer the evapotranspiratory demand, highlighting possible future deficits of green water stocks. Blue water fluxes are found significantly decreasing during summer, when in winter, discharge in the higher part of the watershed is found increasing because of a lower snow stock associated to an increase of liquid precipitation, benefiting surface runoff.
Aphasia: Progress in the last quarter of a century

In the last 25 years, characterization of aphasia has shifted from descriptions of the language tasks that are impaired by brain damage to identification of the disrupted cognitive processes underlying language. At the same time advances in technology, including functional imaging, electrophysiologic studies, perfusion imaging, diffusion tensor imaging, and transcranial magnetic stimulation, have led to new insights regarding the relationships between language and the brain. These insights, together with computational models of language processes, converge on the view that a given language task relies on a complex set of cognitive processes and representations carried out by an intricate network of neural regions working together. Recovery from aphasia depends on restoration of tissue function or reorganization of the cognitive/neural network underlying language, which can be facilitated by a number of diverse interventions. The original research by the author reported in this article was supported by NIH R01 DC05375.
Pathobiology of Hodgkin Lymphoma

Hodgkin’s lymphoma is a lymphoid tumour that represents about 1% of all de novo neoplasms occurring every year worldwide. Its diagnosis is based on the identification of characteristic neoplastic cells within an inflammatory milieu. Molecular studies have shown that most, if not all cases, belong to the same clonal population, which is derived from peripheral B-cells. The relevance of Epstein-Barr virus infection at least in a proportion of patients was also demonstrated. The REAL/WHO classification recognizes a basic distinction between nodular lymphocyte predominance HL (NLPHL) and classic HL (CHL), reflecting the differences in clinical presentation, behavior, morphology, phenotype, molecular features as well as in the composition of their cellular background. CHL has been classified into four subtypes: lymphocyte rich, nodular sclerosing, mixed cellularity and lymphocyte depleted. Despite its well known histological and clinical features, Hodgkin’s lymphoma (HL) has recently been the object of intense research activity, leading to a better understanding of its phenotype, molecular characteristics and possible mechanisms of lymphomagenesis.
Air-flow patterns and ciliary activity in the trachea after tracheotomy. A method of determination in vitro of the rate of ciliary beat in a tracheal model.

An experimental method for studying the rate of ciliary beat on pieces of respiratory mucous membranes exposed to artificial to-and-fro ventilation has been evolved and tested.The influence on the rate of ciliary beat exerted by some aerodynamic factors just below a constriction (e.g. the larynx, a tracheal cannula, a pathological stenosis) in the airways is demonstrated.The efficiency of heat-and-moisture exchangers (HME's) used in posttracheotomy care appears from their influence upon the function of respiratory mucous membranes.It is also shown that ciliary activity, which has been stopped by drying for a short time, can be regained with the use of a HME.Finally, the present method seems well suited for testing the influence exerted by single physical factors and also by chemical substances on the rate of the ciliary beat of respiratory mucous membranes.
Invariant EKF Design for Scan Matching-Aided Localization

Localization in indoor environments is a technique that estimates the robot's pose by fusing data from onboard motion sensors with readings of the environment, in our case obtained by scan matching point clouds captured by a low-cost Kinect depth camera. We develop both an invariant extended Kalman filter (IEKF)-based and a multiplicative extended Kalman filter-based solution to this problem. The two designs are successfully validated in experiments and demonstrate the advantage of the IEKF design.
Transient Neonatal Diabetes , ZFP 57 , and Hypomethylation ofMultiple Imprinted Loci A detailed follow-up

SUSANNE E. BOONEN, MD, PHD DEBORAH J.G. MACKAY, PHD JOHANNE M.D. HAHNEMANN, MD, PHD LOUISE DOCHERTY, PHD KAREN GRØNSKOV, PHD ANNA LEHMANN, PHD LISE G. LARSEN, MD ANDREAS P. HAEMERS, MD YVES KOCKAERTS, MD LUTGARDE DOOMS, MD D~ uNG CH I V~ u, MD C.T. BICH NGOC, MD PHUONG BICH NGUYEN, MD OLGA KORDONOURI, MD FRIDA SUNDBERG, MD PINAR DAYANIKLI, MD, FAAP VIJITH PUTHI, MD CARLO ACERINI, MD AHMED F. MASSOUD, MD, MBBS, FRCP,
Health care needs of people with learning disabilities Ordinary health care needs

Comprehensive health care services respond effectively to the needs of their patients not just in terms of treatment of health problems but also by addressing overall well-being by understanding, informing, involving, counselling and respecting the individual. By contrast, the history of health care for people with learning disabilities has been characterised by a lack of communication and poor understanding of their ordinary and special needs. There have been many barriers to access to health services that most members of the population take for granted. In addition, people with learning disabilities have many special health care needs that also have to be addressed. Therefore, person-centred services must be aware of the wide range of needs to which they must be able to respond while treating each person as an individual (see Box 1).
The Pearson-Readhead Survey of Compact Extragalactic Radio Sources from Space. II. Analysis of Source Properties

We have performed a multidimensional correlation analysis on the observed properties of a statistically complete core-selected sample of compact radio-loud active galactic nuclei based on data from the VLBI Space Observing Programme (Paper I) and previously published studies. Our sample is drawn from the well-studied Pearson-Readhead (PR) survey and is ideally suited for investigating the general effects of relativistic beaming in compact radio sources. In addition to confirming many previously known correlations, we have discovered several new trends that lend additional support to the beaming model. These trends suggest that the most highly beamed sources in core-selected samples tend to have (1) high optical polarizations; (2) large parsec- kiloparsec-scale jet misalignments; (3) prominent VLBI core components; (4) one-sided, core, or halo radio morphology on kiloparsec scales; (5) narrow emission line equivalent widths; and (6) a strong tendency for intraday variability at radio wavelengths. We have used higher resolution space and ground-based VLBI maps to confirm the bimodality of the jet misalignment distribution for the PR survey and find that the sources with aligned parsec- and kiloparsec-scale jets generally have arcsecond-scale radio emission on both sides of the core. The aligned sources also have broader emission line widths. We find evidence that the BL Lacertae objects in the PR survey are all highly beamed and have very similar properties to the high optically polarized quasars, with the exception of smaller redshifts. A cluster analysis on our data shows that after partialing out the effects of redshift, the luminosities of our sample objects in various wave bands are generally well correlated with each other but not with other source properties.
Performance evaluation of device discovery in bluetooth LE with probabilistic model checking

The device discovery in Bluetooth is needed before establishing data communications. Almost all Bluetooth slaves are battery-powered so that they should connect with a master through the device discovery for a short time. To prevent the worst case scenario with long device discovery in Bluetooth, the events with long device discovery should be estimated in advance. However, it is intractable to estimate the exact longest device discovery time with Monte Carlo simulations or mathematical analysis because of the probabilistic behavior. In this paper, we reveal the longest device discovery time and the maximum energy consumption in Bluetooth Low Energy (LE) with a probabilistic model checking tool, PRISM. The results show that some parameters in Bluetooth LE will largely affect the energy consumption so that their design criteria will be desired to reduce the energy consumption.
UvA-DARE ( Digital Academic Repository ) Role of CD 14 in a Mouse Model of Acute Lung Inflammation Induced by Different Lipopolysaccharide

Background: Recognition of lipopolysaccharide (LPS) is required for effective defense against invading gram-negative bacteria. Recently, in vitro studies revealed that CD14 is required for activation of the myeloid differentiation factor (MyD)88dependent Toll-like receptor (TLR)4 signaling pathway by smooth (S)-LPS, but not by rough (R)-LPS. The present study investigated the role of CD14 in induction of lung inflammation in mice by these different LPS chemotypes. Methodology/Results: Neutrophil accumulation and tumor necrosis factor (TNF) release in bronchoalveolar lavage fluid were determined 6 hours after intranasal treatment of wild type (WT) and CD14 knock-out (KO) mice with different doses SLPS or R-LPS. The contribution of CD14 to lung inflammation induced by S-LPS or R-LPS depended on the LPS dose. At low doses, S-LPS and R-LPS induced neutrophil influx in a CD14-dependent manner. Low dose S-LPS-induced cytokine release also depended on CD14. Strikingly, neutrophil influx and TNF release induced by high dose S-LPS or R-LPS was diminished in the presence of CD14. Intranasal administration of sCD14 to CD14 KO mice treated with S-LPS partially reversed the inflammatory response to the response observed in WT mice. Conclusions: In conclusion, CD14 modulates effects of both S-LPS and R-LPS within the lung in a similar way. Except for RLPS-induced TNF release, S-LPS and R-LPS at low dose induced acute lung inflammation in a CD14-dependent manner, while the inflammatory response triggered by high dose S-LPS or R-LPS was diminished by CD14. Citation: Anas AA, Hovius JWR, van ’t Veer C, van der Poll T, de Vos AF (2010) Role of CD14 in a Mouse Model of Acute Lung Inflammation Induced by Different Lipopolysaccharide Chemotypes. PLoS ONE 5(4): e10183. doi:10.1371/journal.pone. 0010183 Editor: Ulrich A. Maus, Hannover School of Medicine, Germany Received November 30, 2009; Accepted March 24, 2010; Published April 16, 2010 Copyright: 2010 Anas et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This work was funded by the Academic Medical Center, Amsterdam, The Netherlands. The funder had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist. * E-mail: a.f. devos@amc.uva. nl
Enabling dynamic linkage of linguistic census data at Statistics Canada (extended abstract)

Research in population health consists in studying the impact of various factors (determinants) on health, with the longterm objective of yielding better policies, programs, and services. Researchers of Official Language Minority Communities (OLMCs) focus specifically on determinants related to speaking a minority language, such as English in Quebec, or French in the rest of Canada. Investigations of this type require the possibility of associating health data to linguistic information. Unfortunately, the largest health databases in Ontario, held at the Institute for Clinical Evaluative Sciences (ICES), do not contain usable linguistic variables to date. High-quality language variables however exist at Statistics Canada (2006 Census), and we are interested in enabling its linkage to ICES health data in a dynamic way. The linkage we consider is intrinsically transient and aggregated: it consists in allowing ICES to learn interactively how many Francophones are present in a given sample of individuals (sum queries). We suggest two possible privacy-preserving mechanisms to enable dynamic sum queries: 1) by constraining the dataflow itself; 2) by adapting recent results ([1]) to characterize what leakage is at play in our scenario and what parameters impact the tradeoff between leakage and utility. We rely on these results to argue that a safe exposition of linguistic data could indeed be envisioned, and beyond, that similar techniques could be used to enrich provincial health databases in general with a range of federal census data, making it possible to perform fine-grained community-based studies in Canada.
Activation of EGFR Bypass Signaling by TGFα Overexpression Induces Acquired Resistance to Alectinib in ALK-Translocated Lung Cancer Cells

Alectinib is a highly selective ALK inhibitor and shows promising efficacy in non–small cell lung cancers (NSCLC) harboring the EML4-ALK gene rearrangement. The precise mechanism of acquired resistance to alectinib is not well defined. The purpose of this study was to clarify the mechanism of acquired resistance to alectinib in ALK-translocated lung cancer cells. We established alectinib-resistant cells (H3122-AR) from the H3122 NSCLC cell line, harboring the EML4-ALK gene rearrangement, by long-term exposure to alectinib. The mechanism of acquired resistance to alectinib in H3122-AR cells was evaluated by phospho-receptor tyrosine kinase (phospho-RTK) array screening and Western blotting. No mutation of the ALK-TK domain was found. Phospho-RTK array analysis revealed that the phosphorylation level of EGFR was increased in H3122-AR cells compared with H3122. Expression of TGFα, one of the EGFR ligands, was significantly increased and knockdown of TGFα restored the sensitivity to alectinib in H3122-AR cells. We found combination therapy targeting ALK and EGFR with alectinib and afatinib showed efficacy both in vitro and in a mouse xenograft model. We propose a preclinical rationale to use the combination therapy with alectinib and afatinib in NSCLC that acquired resistance to alectinib by the activation of EGFR bypass signaling. Mol Cancer Ther; 15(1); 162–71. ©2015 AACR.
Microendocytosis in eosinophilic leukocytes

Rat peritoneal eosinophils were examined after intraperitoneal infusion either of a mixture of phosphate-buffered saline (PBS) and colloidal gold or of fetal calf serum. These cells characteristically contained vesiculotubular structures, cuplike structures, and small granules during centrifugation. The cup-shaped structures and elaborate labyrinths of vacuole-like spaces increased markedly after injection of the PBS-colloidal gold mixture, presumably as features of heightened microendocytic activity. The vesiculotubular structures increased greatly after infusion of fetal calf serum. A few cyrstalloid granules exhibited fine-structural changes after the PBS-colloidal gold injection, and more numerous crystalloid granules appeared altered after fetal calf serum. Infrequent small granules contained a lucent, crystal-like silhouette after the fetal calf serum injection. Eosinophils evidenced microendocytic uptake of gold spherules into coated vesicles, the cup-shaped structures, and the small granules, but not into the vesiculotubular structures or crystalloid granules after intraperitoneal infusion of the PBS-gold mixture. Strong unmasked acid phosphatase activity in small granules contrasted with the general lack of activity in normal-appearing crystalloid granules and moderate activity in apparently altered crystalloid granules, presumably reflecting active and latent forms of enzyme in the different granules.
Speciication and Validation of a Network Security Policy Model Speciication and Validation of a Network Security Policy Model

This case study concerns the speciication and validation of a Security Policy Model (SPM) for an electronic network. The network is intended to provide processing and transmission services for electronic messages, including sensitive and classiied material, over distributed sites and supporting multiple levels of security classiication. The SPM is formally speciied in VDM-SL and validated by showing that the model is mathematically consistent and satisses certain security properties. Rigorous proofs are provided. In addition, the case study illustrates some new techniques concerning proof obligations for exception conditions in VDM-SL.
Extending the Uintah Framework through the Petascale Modeling of Detonation in Arrays of High Explosive Devices

The Uintah software framework for the solution of a broad class of fluid-structure interaction problems has been developed by using a problem-driven approach that dates back to its inception. Uintah uses a layered task-graph approach that decouples the problem specification as a set of tasks from the adaptive runtime system that executes these tasks. Using this approach, it is possible to improve the performance of the software components to enable the solution of broad classes of problems as well as the driving problem itself. This process is illustrated by a motivating problem: the computational modeling of the hazards posed by thousands of explosive devices during a deflagration-to-detonation transition that occurred on Highway 6 in Utah. In order to solve this complex fluid-structure interaction problem at the required scale, substantial algorithmic and data structure improvements were needed to Uintah. These improvements enabled scalable runs for the target problem and provided the capability to mode.
Spatio-Temporal Image Boundary Extrapolation

Boundary prediction in images as well as video has been a very active topic of research and organizing visual information into boundaries and segments is believed to be a corner stone of visual perception. While prior work has focused on predicting boundaries for observed frames, our work aims at predicting boundaries of future unobserved frames. This requires our model to learn about the fate of boundaries and extrapolate motion patterns. We experiment on established real-world video segmentation dataset, which provides a testbed for this new task. We show for the first time spatio-temporal boundary extrapolation in this challenging scenario. Furthermore, we show long-term prediction of boundaries in situations where the motion is governed by the laws of physics. We successfully predict boundaries in a billiard scenario without any assumptions of a strong parametric model or any object notion. We argue that our model has with minimalistic model assumptions derived a notion of 'intuitive physics' that can be applied to novel scenes.
Online bin packing with cardinality constraints resolved

Cardinality constrained bin packing or bin packing with cardinality constraints is a basic bin packing problem. In the online version with the parameter k \geq 2, items having sizes in (0,1] associated with them are presented one by one to be packed into unit capacity bins, such that the capacities of bins are not exceeded, and no bin receives more than k items. We resolve the online problem in the sense that we prove a lower bound of 2 on the overall asymptotic competitive ratio. This closes this long standing open problem, since an algorithm of an absolute competitive ratio 2 is known. Additionally, we significantly improve the known lower bounds on the asymptotic competitive ratio for every specific value of k. The novelty of our constructions is based on full adaptivity that creates large gaps between item sizes. Thus, our lower bound inputs do not follow the common practice for online bin packing problems of having a known in advance input consisting of batches for which the algorithm needs to be competitive on every prefix of the input.
GreenTE: Power-aware traffic engineering

Current network infrastructures exhibit poor power efficiency, running network devices at full capacity all the time regardless of the traffic demand and distribution over the network. Most research on router power management are at component level or link level, treating routers as isolated devices. A complementary approach is to facilitate power management at network level by routing traffic through different paths to adjust the workload on individual routers or links. Given the high path redundancy and low link utilization in today's large networks, this approach can potentially allow more network devices or components to go into power saving mode. This paper proposes an intra-domain traffic engineering mechanism, GreenTE, which maximizes the number of links that can be put into sleep under given performance constraints such as link utilization and packet delay. Using network topologies and traffic data from several wide-area networks, our evaluation shows that GreenTE can reduce line-cards' power consumption by 27% to 42% under constraints that the maximum link utilization is below 50% and the network diameter remains the same as in shortest path routing.
Transport mechanism of the leakage current in MIS capacitor with HfO2/SiO2 stack gate

I-V characteristic of the HfO<inf>2</inf>/SiO<inf>2</inf> stack gate MIS capacitor is investigated. The gate leakage current in HfO<inf>2</inf>/SiO<inf>2</inf> stack gate MIS capacitor decreases after constant voltage stress, which is caused by electron trapping. By analyzing the experiment and calculation results, the main transport mechanisms of the gate leakage current in HfO<inf>2</inf>/SiO<inf>2</inf> stack gate is presented. The different transport mechanisms in HfO<inf>2</inf> gate and HfO<inf>2</inf>/SiO<inf>2</inf> stack gate are proposed.