Miracle-dz/UniFAR-FTUs huggingface dataset:
Tactile stimulation in very preterm infants and their needs of non-invasive respiratory support

Aim Despite the lack of evidence, current resuscitation guidelines recommend tactile stimulation in apneic infants within the first minutes of life. The aim was to investigate whether timing, duration or intensity of tactile stimulation influences the extent of non-invasive respiratory support in extremely preterm infants during neonatal resuscitation. Methods In an observational study, we analyzed 47 video recordings and physiological parameters during postnatal transition in preterm infants below 320/7 weeks of gestational age. Infants were divided into three groups according to the intensity of respiratory support. Results All infants were stimulated at least once during neonatal resuscitation regardless of their respiratory support. Only 51% got stimulated within the first minute. Rubbing the feet was the preferred stimulation method and was followed by rubbing or touching the chest. Almost all very preterm infants were exposed to stimulation and manipulation most of the time within their first 15 min of life. Tactile stimulation lasted significantly longer but stimulation at multiple body areas started later in infants receiving prolonged non-invasive respiratory support. Conclusion This observational study demonstrated that stimulation of very preterm infants is a commonly used and easy applicable method to stimulate spontaneous breathing during neonatal resuscitation. The concomitant physical stimulation of different body parts and therefore larger surface areas might be beneficial.
Spin dynamics of a tetrahedral cluster magnet

We study the magnetism of a lattice of coupled tetrahedral spin-1/2 clusters which might be of relevance to the tellurate compounds ${\mathrm{Cu}}_{2}{\mathrm{Te}}_{2}{\mathrm{O}}_{5}{X}_{2},$ with $X=\mathrm{Cl},$ Br. Using the flow equation method we perform a series expansion in terms of the inter-tetrahedral exchange couplings starting from the quadrumer limit. Results will be given for the magnetic instabilities of the quadrumer phase and the dispersion of elementary triplet excitations. In limiting cases of our model of one- or two-dimensional character we show our results to be consistent with findings on previously investigated decoupled tetrahedral chains and the Heisenberg model on the 1/5-depleted square lattice.
Photon opacity in surfaces of magnetic neutron stars

Approximate expressions are derived for free-free, bound-free, and Thomson cross-sections of photons by gaseous matter in the presence of superstrong magnetic fields. For photons in modes whose electric field polarization is perpendicular to this magnetic field, the cross-section is reduced by approximately the squared ratio of the photon frequency to the electron cyclotron frequency if this ratio is small.
Fish oil and probiotics supplementation through milk chocolate improves spatial learning and memory in male Wistar rats

Background Cognition and brain function is critical through childhood and should be improved with balanced diets. Incorporating bioactive ingredients such as omega-3 polyunsaturated fatty acids (ω3 PUFAs) and probiotics into food formulations could be used as an approach to improve cognitive function. This study evaluated the effects on cognitive capacity of complementing rodent diets with chocolate, by itself and in combination with ω3 PUFAs from fish oil and probiotics. Methods Spatial learning and memory in the rats were determined by the Barnes maze test in short- and long-term memory. Samples from the cecum were obtained to assess microbial counts (Lactobacillus, Bifidobacterium, Enterobacteriaceae, and total bacteria), and brains were recovered to analyze the neural morphology of the tissues. Also, glucose, brain weights, and epididymal tissue were analyzed. Results The combination of chocolate with fish oil and probiotics improved the memory of rats compared to the result of each bioactive compound when evaluated separately. Treatments did not affect sugar level, epididymal adipose tissue, or brain weight. On the other hand, consuming probiotics alone or in combination with chocolate decreased Enterobacteria counts, while Lactobacillus and Bifidobacteria counts were not affected. Neural morphological analysis showed that combining chocolate with probiotics and ω3 PUFAs increased the number of neurons in the hippocampal CA1 and CA3 regions. Conclusion Chocolate added with probiotics and ω3 PUFAs improved spatial memory and learning in the studied model.
Endogenous configuration space approach to mobile manipulators: A derivation and performance assessment of Jacobian inverse kinematics algorithms

By a mobile manipulator we mean a robotic system composed of a non-holonomic mobile platform and a holonomic manipulator fixed to the platform. A taskspace of the mobile manipulator includes positions and orientations of its end effector relative to an inertial coordinate frame. The kinematics of a mobile manipulator are represented by a driftless control system with outputs. Admissible control functions of the platform along with joint positions of the manipulator constitute the endogenous configuration space. Endogenous configurations have a meaning of controls. A map from the endogenous configuration space into the taskspace is referred to as the instantaneous kinematics of the mobile manipulator. Within this framework, the inverse kinematic problem for a mobile manipulator amounts to defining an endogenous configuration that drives the end effector to a desirable position and orientation in the taskspace. Exploiting the analogy between stationary and mobile manipulators we present in the paper a collection of regular and singular Jacobian inverse kinematics algorithms. Their performance is evaluated on the basis of intense computer simulations.
Identification of a novel oxidative stress-related prognostic model in lung adenocarcinoma

Background: Oxidative stress (OxS) participates in a variety of biological processes, and is considered to be related to the occurrence and progression of many tumors; however, the potential diagnostic value of OxS in lung cancer remains unclear. Methods: The clinicopathological and transcriptome data for lung adenocarcinoma (LUAD) were collected from TCGA and GEO database. LASSO regression was used to construct a prognostic risk model. The prognostic significance of the OxS-related genes was explored using a Kaplan-Meier plotter database. The prediction performance of the risk model was shown in both the TCGA and GSE68465 cohorts. The qRT-PCR was performed to explore the expression of genes. CCK-8, Edu and transwell assays were conducted to analyze the role of CAT on cell proliferation migration and invasion in lung cancer. Immune infiltration was evaluated by CIBERSORT and mutational landscape was displayed in the TCGA database. Moreover, the relationship between risk score with drug sensitivity was investigated by pRRophetic. Results: We identified a prognosis related risk model based on a four OxS gene signature in LUAD, including CYP2D6, FM O 3, CAT, and GAPDH. The survival analysis and ROC curve indicated good predictive power of the model in both the TCGA and GEO cohorts. LUAD patients in the high-risk group had a shorter OS compared to the low-risk group. QRT-PCR result showed that the expression of four genes was consistent with previous analysis in cell lines. Moreover, overexpression of CAT could decrease the proliferation, invasion and migration of lung cancer cells. The Cox regression analysis showed that the risk score could be used as an independent prognostic factor for OS. LUAD patients in the high-risk score group exhibited a higher tumor mutation burden and risk score were closely related to tumor associated immune cell infiltration, as well as the expression of immune checkpoint molecules. Both the high- and low-risk groups have significant differences in sensitivity to some common chemotherapy drugs, such as Paclitaxel, Docetaxel, and Vinblastine, which may contribute to clinical treatment decisions. Conclusion: We established a robust OxS-related prognostic model, which may contribute to individualized immunotherapeutic strategies in LUAD.
Quantitation of Absorbers in Turbid Media Using Time-Integrated Spectroscopy Based on Microscopic Beer-Lambert Law

Based on the microscopic Beer-Lambert law, two practical time-integrated spectroscopy (TIS) methods, called dual-wavelength spectroscopy method, and dual-wavelength and dual-site spectroscopy method, are described to determine the absolute concentration of an absorber in variously shaped turbid media. We demonstrate, for the first time, the validity of the TIS methods by means of experiments in which the absolute concentrations of an absorber in a tissue-like phantom were determined with errors less than several percent. The advantages and disadvantages of both methods are also discussed.
Endocrine system involvement in patients with RASopathies: A case series

Background and Objectives Endocrine complications have been described in patients affected by RASopathies but no systematic assessment has been reported. In this study, we investigate the prevalence of endocrine disorders in a consecutive unselected cohort of patients with RASopathies. Study Design 72 patients with a genetically confirmed RASopathy (Noonan syndrome [NS], N=53; 29 LEOPARD syndrome [LS], N=2; cardiofaciocutaneous syndrome [CFCS], N=14; subjects showing co-occurring pathogenic variants in PTPN11 and NF1, N=3) and an age- and sex-matched healthy controls were included in the study. Endocrine system involvement was investigated by assessing the thyroid function, pubertal development, auxological parameters, adrenal function and bone metabolism. Results Short stature was detected in 40% and 64% of the NS and CFCS subcohorts, respectively. Patients showed lower Z-scores at DXA than controls (p<0.05) when considering the entire case load and both NS and CFCS groups. Vitamin D and Calcitonin levels were significantly lower (p< 0.01), Parathormone levels significantly higher (p<0.05) in patients compared to the control group (p<0.05). Patients with lower BMD showed reduced physical activity and joint pain. Finally, anti-TPO antibody levels were significantly higher in patients than in controls when considering the entire case load and both NS and CFCS groups. Conclusions The collected data demonstrate a high prevalence of thyroid autoimmunity, confirming an increased risk to develop autoimmune disorders both in NS and CFCS. Reduced BMD, probably associated to reduced physical activity and inflammatory cytokines, also occurs. These findings are expected to have implications for the follow-up and prevention of osteopenia/osteoporosis in both NS and CFCS.
Dissociation of categorical and coordinate spatial relations on dynamic network organization states

Humans can flexibly represent both categorical and coordinate spatial relations. Previous research has mainly focused on hemisphere lateralization in representing these two types of spatial relations, but little is known about how distinct network organization states support representations of the two. Here we used dynamic resting-state functional connectivity (FC) to explore this question. To do this, we separated a meta-identified navigation network into a ventral and two other subnetworks. We revealed a Weak State and a Strong State within the ventral subnetwork and a Negative State and a Positive State between the ventral and other subnetworks. Further, we found the Weak State (i.e., weak but positive FC) within the ventral subnetwork was related to the ability of categorical relation recognition, suggesting that the representation of categorical spatial relations was related to weak integration among focal regions in the navigation network. In contrast, the Negative State (i.e., negative FC) between the ventral and other subnetworks was associated with the ability of coordinate relation processing, suggesting that the representation of coordinate spatial relations may require competitive interactions among widely distributed regions. In sum, our study provides the first empirical evidence revealing different focal and distributed organizations of the navigation network in representing different types of spatial information.
Experimental determination of the nonextensive entropic parameter q

We show how to extract the $q$ parameter from experimental data, considering an inhomogeneous magnetic system composed by many Maxwell-Boltzmann homogeneous parts, which after integration over the whole system recover the Tsallis nonextensivity. Analyzing the cluster distribution of ${\mathrm{La}}_{0.7}{\mathrm{Sr}}_{0.3}\mathrm{Mn}{\mathrm{O}}_{3}$ manganite, obtained through scanning tunneling spectroscopy, we measure the $q$ parameter and predict the bulk magnetization with good accuracy. The connection between the Griffiths phase and nonextensivity is also considered. We conclude that the entropic parameter embodies information about the dynamics, the key role to describe complex systems.
Low-temperature high-resolution magnetic force microscopy using a quartz tuning fork

We have developed a low-temperature high resolution magnetic force microscope (MFM) using a quartz tuning fork that can operate in a magnetic field. A tuning fork with a spring constant of 1300N∕m mounted with a commercial MFM cantilever tip was used. We have obtained high-resolution images of the stray magnetic fields exerted from grains with a spatial resolution of 15 nm and force resolution of 2 pN at 4.2 K. Tuning fork-based magnetic force microscopes have the potential to be used at millikelvin temperatures due to their low power dissipation and high force sensitivity.
Human nasal olfactory stem cells, purified as advanced therapy medicinal products, improve neuronal differentiation

Background Olfactory ecto-mesenchymal stem cells (OE-MSC) are mesenchymal stem cells derived from the lamina propria of the nasal mucosa. They display neurogenic and immunomodulatory properties and were shown to induce recovery in animal models of spinal cord trauma, hearing loss, Parkinsons’s disease, amnesia, and peripheral nerve injury. As a step toward clinical practice, we sought to (i) devise a culture protocol that meets the requirements set by human health agencies and (ii) assess the efficacy of stem cells on neuron differentiation. Methods Nasal olfactory mucosa biopsies from three donors were used to design and validate the good manufacturing process for purifying stem cells. All processes and procedures were performed by expert staff from the cell therapy laboratory of the public hospital of Marseille (AP-HM), according to aseptic handling manipulations. Premises, materials and air were kept clean at all times to avoid cross-contamination, accidents, or even fatalities. Purified stem cells were cultivated for 24 or 48 h and conditioned media were collected before being added to the culture medium of the neuroblastoma cell line Neuro2a. Results Compared to the explant culture-based protocol, enzymatic digestion provides higher cell numbers more rapidly and is less prone to contamination. The use of platelet lysate in place of fetal calf serum is effective in promoting higher cell proliferation (the percentage of CFU-F progenitors is 15.5%), with the optimal percentage of platelet lysate being 10%. Cultured OE-MSCs do not show chromosomal rearrangement and, as expected, express the usual phenotypic markers of mesenchymal stem cells. When incorporated in standard culture medium, the conditioned medium of purified OE-MSCs promotes cell differentiation of Neuro2a neuroblastoma cells. Conclusion We developed a safer and more efficient manufacturing process for clinical grade olfactory stem cells. With this protocol, human OE-MSCs will soon be used in a Phase I clinical based on their autologous transplantation in digital nerves with a neglected injury. However, further studies are required to unveil the underlying mechanisms of action.
Comparison between the Logotropic and ΛCDM models at the cosmological scale

We perform a detailed comparison between the Logotropic model [P.H. Chavanis, Eur. Phys. J. Plus, 130 (2015)] and the ΛCDM model. These two models behave similarly at large (cosmological) scales up to the present. Differences will appear only in the far future, in about 25 Gyrs, when the Logotropic Universe becomes phantom while the ΛCDM Universe enters in the de Sitter era. However, the Logotropic model differs from the ΛCDM model at small (galactic) scales, where the latter encounters serious problems. Having a nonvanishing pressure, the Logotropic model can solve the cusp problem and the missing satellite problem of the ΛCDM model. In addition, it leads to dark matter halos with a constant surface density Σ0=ρ0 rh, and can explain its observed value Σ0=141 M⊙/pc2 without adjustable parameter. This makes the logotropic model rather unique among all the models attempting to unify dark matter and dark energy. In this paper, we compare the Logotropic and ΛCDM models at the cosmological scale where they are very close to each other in order to determine quantitatively how much they differ. This comparison is facilitated by the fact that these models depend on only two parameters, the Hubble constant H0 and the present fraction of dark matter Ωm0. Using the latest observational data from Planck 2015+Lensing+BAO+JLA+HST, we find that the best fit values of H0 and Ωm0 are H0=68.30 km s−1 Mpc−1 and Ωm0=0.3014 for the Logotropic model, and H0=68.02 km s−1 Mpc−1 and Ωm0=0.3049 for the ΛCDM model. The difference between the two models is at the percent level. As a result, the Logotropic model competes with the ΛCDM model at large scales and solves its problems at small scales. It may therefore represent a viable alternative to the ΛCDM model. Our study provides an explicit example of a theoretically motivated model that is almost indistinguishable from the ΛCDM model at the present time while having a completely different (phantom) evolution in the future. We analytically derive the statefinders of the Logotropic model for all values of the logotropic constant B. We show that the parameter s0 is directly related to this constant since s0=−B/(B+1) independently of any other parameter like H0 or Ωm0. For the predicted value of B=3.53× 10−3, we obtain (q0,r0,s0)=(−0.5516,1.011,−0.003518) instead of (q0,r0,s0)=(−0.5427,1,0) for the ΛCDM model corresponding to 0B=.
Single-cell transcriptome sequencing revealing the difference in photosynthesis and carbohydrate metabolism between epidermal cells and non-epidermal cells of Gracilariopsis lemaneiformis (Rhodophyta)

The allocation of photoassimilates is considered as a key factor for determining plant productivity. The difference in photosynthesis and carbohydrate metabolism between source and sink cells provide the driven force for photoassimilates’ allocation. However, photosynthesis and carbohydrate metabolism of different cells and the carbon allocation between these cells have not been elucidated in Gracilariopsis lemaneiformis. In the present study, transcriptome analysis of epidermal cells (EC) and non-epidermal cells (NEC) of G. lemaneiformis under normal light conditions was carried out. There were 3436 differentially expressed genes (DEGs) identified, and most of these DEGs were related to photosynthesis and metabolism. Based on a comprehensive analysis both at physiological and transcriptional level, the activity of photosynthesis and carbohydrate metabolism of EC and NEC were revealed. Photosynthesis activity and the synthesis activity of many low molecular weight carbohydrates (floridoside, sucrose, and others) in EC were significantly higher than those in NEC. However, the main carbon sink, floridean starch and agar, had higher levels in NEC. Moreover, the DEGs related to transportation of photoassimilates were found in this study. These results suggested that photoassimilates of EC could be transported to NEC. This study will contribute to our understanding of the source and sink relationship between the cells in G. lemaneiformis.
A Herschel/PACS Far-infrared Line Emission Survey of Local Luminous Infrared Galaxies

We present an analysis of , [O iii]88, [N ii]122, and far-infrared (FIR) fine-structure line observations obtained with Herschel/PACS, for ∼240 local luminous infrared galaxies (LIRGs) in the Great Observatories All-sky LIRG Survey. We find pronounced declines (“deficits”) of line-to-FIR continuum emission for [N ii]122, , and as a function of FIR color and infrared luminosity surface density, . The median electron density of the ionized gas in LIRGs, based on the [N ii]122/[N ii]205 ratio, is = 41 cm−3. We find that the dispersion in the deficit of LIRGs is attributed to a varying fractional contribution of photodissociation regions (PDRs) to the observed emission, f( ) = / , which increases from ∼60% to ∼95% in the warmest LIRGs. The / ratio is tightly correlated with the PDR gas kinetic temperature in sources where is not optically thick or self-absorbed. For each galaxy, we derive the average PDR hydrogen density, , and intensity of the interstellar radiation field, G, in units of and find G/ ratios of ∼0.1–50 cm3, with ULIRGs populating the upper end of the distribution. There is a relation between G/ and , showing a critical break at ≃ 5 × 1010 L⊙ kpc−2. Below , G/ remains constant, ≃0.32 cm3, and variations in are driven by the number density of star-forming regions within a galaxy, with no change in their PDR properties. Above , G/ increases rapidly with , signaling a departure from the typical PDR conditions found in normal star-forming galaxies toward more intense/harder radiation fields and compact geometries typical of starbursting sources.
3-mirror systems for large wide-field telescopes

This study investigates the feasibility of a fast, wide-field imaging telescope using a mosaic CCD detector system. A 3- mirror design is proposed to obtain good image quality over a 2 degree field-of-view at an aperture of 2.5 m. The layout is shown to be practical with current technologies, leading to a modern telescope with potentially very good seeing properties.
Transformation and upgrading path for midstream manufacturers in the chain: Taking Shennan Circuits as an example

The restructuring of global value chain restructuring has created both opportunities and challenges for Chinese manufacturers. In the process, OEM-ODM-OBM has been a typical upgrade path for manufacturing enterprises to integrate into the global value chain. However, this path may not be appropriate for Chinese midstream enterprises in the industry chain. This paper performs a longitudinal analysis of 30-year reform of Shennan Circuits, a typical midstream manufacturing business in the industry chain in China. Based on the smiling curve theory, we systematically analyzed how Shennan Circuit constantly scanned over the industry, its customers, competitors, and leveraged its own capability and resources against the background of global value chain restructuring to successfully integrate into the global value chain, enhance competitiveness while completing business transformation and upgrade. Given the case study, this paper proposes three types of transformation solutions with eight specific paths and the ICCA opportunity scanning analysis method for China’s midstream manufacturers in the industry chain as references.