Miracle-dz/UniFAR-FTUs huggingface dataset:
Independent of Repertoire Diversity Fitness of Cell-Mediated Immunity

Jeffrey L. Platt and Marilia CascalhoWettstein, Zvezdana Vuk-Pavlovic, Andrew H. Limper, Mouhammed AbuAttieh, Michelle Rebrovich, Peter J.http://www.jimmunol.org/content/178/5/2950J Immunol€2007; 178:2950-2960; ;Referenceshttp://www.jimmunol.org/content/178/5/2950.full#ref-list-1This article cites 59 articles, 27 of which you can access for free at: Subscriptionshttp://jimmunol.org/subscriptionsInformation about subscribing to The Journal of Immunology is online at: Permissionshttp://www.aai. org/ji/copyright.htmlSubmit copyright permission requests at: Email Alertshttp://jimmunol.org/cgi/alerts/etocReceive free email-alerts when new articles cite this article. Sign up at:
ADDIS: an automated way to do network meta-analysis

In evidence-based medicine, meta-analysis is an important statistical technique for combining the findings from independent clinical trials which have attempted to answer similar questions about treatment's clinical e ectiveness [1]. Normally, such meta-analyses are pair-wise treatment comparisons, which only include the comparisons between two treatments, e.g. treatment A and placebo. When additional treatments are of interest (e.g. treatment B and treatment C), pair-wise treatment comparison starts showing its limitations as it only accesses the evidence from direct comparisons between two treatments and can not guarantee consistency between comparisons. Network meta-analysis is a statistical method for combining both direct and indirect evidence from multiple trials in order to obtain a single consistent quantitative synthesis [2, 3, 4]. It enables to detect the heterogeneity among di erent trials comparing the same treatments and inconsistency between direct and indirect evidence. Compared to pair-wise meta-analysis, network meta-analysis is rather difficult to conduct due to the need for analyzing inconsistency, specifying the model, assessing convergence, etc. The purpose of this report is to introduce an automated way to perform network meta-analysis through ADDIS (Aggregate Data Drug Information System).
Differences in clinical parameters and tear film of tolerant and intolerant contact lens wearers.

PURPOSE To determine whether intolerance to contact lens wear is attributable to clinical or protein characteristics of the tear film. METHODS Thirty-eight subjects participated; 20 were successful contact lens wearers and 18 had discontinued contact lens wear because of discomfort. Baseline tear film (no lens wear) was analyzed with a range of clinical measurements and protein analyses (lactoferrin, sIgA, and lysozyme). Comfort was determined after 6 hours of lens wear, and differences in tear film characteristics between subject groups were determined. In half of the subject group (n = 19), discriminant analysis was used to develop an equation for predicting the likelihood of intolerance to lens wear. Sensitivity and specificity were determined by testing the formula on the remaining subjects. These formulas were also tested on a separate group of subjects enrolled in a contact lens-wearing trial. RESULTS Tear volume (meniscus height and phenol red thread test) and tear stability (noninvasive tear break up time [NI-TBUT]) were significantly reduced in intolerant wearers (P < 0.05). A greater number of symptoms were reported by intolerant than by tolerant wearers (P < 0.05). Tolerance was associated with clinical but not protein characteristics of the tear film. Formulas best able to predict contact lens intolerance included NI-TBUT, number of symptoms experienced, and tear film meniscus height. Formulas had high sensitivity, and specificity which ranged from 29% to 57%. CONCLUSIONS Contact lens intolerance appears to be best predicted by a combination of clinical variables, including tear film stability, tear volume, and symptom reporting.
A CONTINGENT RESOURCE-BASED ANALYSIS OF ENVIRONMENTAL STRATEGY IN THE SKI INDUSTRY

We undertook a contingent analysis of the influence of organizational capabilities on environmental strategies in ski resorts in North America and Europe. We found that organizational capabilities of stakeholder integration, organizational learning, cross-functional integration, continuous innovation, shared vision, and strategic proactivity are associated with the development of proactive strategies. Managerial perceptions of perceived uncertainty, complexity, and hostility in the general business environment moderate the deployment of these capabilities.
Commentary on: Are we overpathologizing everyday life? A tenable blueprint for behavioral addiction research

This commentary supports the argument that there is an increasing tendency to subsume a range of excessive daily behaviors under the rubric of non-substance related behavioral addictions. The concept of behavioral addictions gained momentum in the 1990s with the recent reclassification of pathological gambling as a non-substance behavioral addiction in DSM-5 accelerating this process. The propensity to label a host of normal behaviors carried out to excess as pathological based simply on phenomenological similarities to addictive disorders will ultimately undermine the credibility of behavioral addiction as a valid construct. From a scientific perspective, anecdotal observation followed by the subsequent modification of the wording of existing substance dependence diagnostic criteria, and then searching for biopsychosocial correlates to justify classifying an excessive behavior resulting in harm as an addiction falls far short of accepted taxonomic standards. The differentiation of normal from non-substance addictive behaviors ought to be grounded in sound conceptual, theoretical and empirical methodologies. There are other more parsimonious explanations accounting for such behaviors. Consideration needs to be given to excluding the possibility that excessive behaviors are due to situational environmental/social factors, or symptomatic of an existing affective disorder such as depression or personality traits characteristic of cluster B personalities (namely, impulsivity) rather than the advocating for the establishment of new disorders.
2 3 M ay 2 00 4 Self-organization in a group of mobile autonomous agents ∗

This paper considers a discrete time swarm model of a group of mobile autonomous agents with a simple attraction and repulsion function for swarm aggregation and investigates its stability properties. In particular, it is proved that the individuals (members) of the swarm will aggregate and form a cohesive cluster of a finite size depending only on the parameters of the swarm model in a finite time, and the swarm system is completely stable.
Evaluating the effectiveness of adaptive tutorial dialogues in EER-Tutor

Researchers have long been interested in tutorial dialogues as they are considered to be one of the critical factors contributing to the effectiveness of human one-on-one tutoring. We discuss an evaluation study that investigates the effectiveness of adaptive tutorial dialogues in database design. EER-Tutor, a database design tutor was enhanced to facilitate adaptive tutorial dialogues. The control group participants received non-adaptive dialogues regardless of their knowledge level and explanation skills. The experimental group participants received adaptive dialogues that were customised based on their student models. The performance on pre- and post-tests indicated that the experimental group participants learned significantly more than their peers. The subjective responses indicated no difference in their impression towards the quality of the dialogues and the understandability of the questions. However there was clear evidence that the control group did not like having to go through the entire dialogue before resuming problem-solving.
A 60GHz-band 20dBm power amplifier with 20% peak PAE

A three-stage, 60GHz transformer-coupled differential power amplifier is implemented in 130nm SiGe-BiCMOS. Common-base differential pair stages extend BVCEO, while neutralization increases isolation, promoting stability. Self-shielded transformers, a parasitic-compensated 4∶1 output combiner and 2∶4 input splitter are designed for low insertion loss and compact dimensions on-chip. Measured small-signal gain is >20dB with over 10GHz −3dB bandwidth. Reverse isolation is better than 51dB across 50–65GHz. Maximum output power and peak-PAE are 20.5dBm and 20%, respectively, at 61.5GHz. The PA consumes 353mW from a 1.8V supply and 0.25mm2 active area.
Severity of baseline alcohol use as a moderator of brief interventions in the emergency department.

AIMS This study examines whether the severity of baseline alcohol consumption/consequences moderates the effect of an alcohol brief intervention (BI) in the emergency department (ED). METHODS Injured patients (N = 494) were recruited from an ED, randomly assigned to receive brief advice or not and completed a 12-month follow-up interview. RESULTS A significant interaction was found between severity of baseline alcohol consumption (i.e. average weekly, binge drinking) and receipt of a BI on alcohol consumption at 12 months. The form of this interaction indicates that the BI group tended to report lower alcohol consumption at follow-up than the untreated group especially in those who had reported high baseline consumption. Severity of alcohol consequences at baseline did not significantly impact the effect of the BI on 12-month outcomes. CONCLUSION ED patients with higher alcohol consumption benefit from BI. In some cases, the BI's effects may be enhanced for patients who are heavier drinkers, perhaps due to a greater opportunity to develop a discrepancy between current behavior and future goals.
AN EMPIRICAL EXAMINATION OF SUPPLY CHAIN PERFORMANCE ALONG SEVERAL DIMENSIONS OF RISK

This research operationalizes several supply chain risk sources and investigates their relationships with supply chain performance. The responses of 760 executives from firms operating in Germany reveal that demand side and supply side risks do have a negative impact on performance whereas regulatory, legal and bureaucratic risks, infrastructure risks, as well as catastrophic risks do not. The analysis and results augment previous research regarding the impact of supply chain risks on the operational performance of firms and shareholder value and provide a detailed analysis of supply chain risk sources as contextual variables in strategic decision-making.
A simplified squall‐line model revisited

We revisit the parametrized moisture model of Garner and Thorpe and show it does indeed support realistic multicellular behaviour when an adequate (and commonly available) amount of instability is present in the initial environment. We also consider the dramatic impact that the simplified model's storms have on their upstream environments, and suggest that this is exaggerated by a fundamental shortcoming in the parametrized moisture framework.
Building a cluster of PC in computer laboratory of Electrical Engineering of UIN Suska Riau

The presence of existing computers in the computer laboratory of Electrical Engineering of UIN Suska Riau is starting to drop behind by the rapid development of computer technology. These problems can overcome by developing existing computer become PC cluster. In this research, we has built a PC cluster that consists of a head node computer, and nine compute node computers. Network topology used is hybrid star-tree topology. The operating system used is openSUSE 11.1, parallel programming specification used is MPI, and parallel programming libraries used are MPICH1. PC clusters have been successfully built and can run parallel programs. Tests of parallel programs using a “Hello World” program in MPI written in C programming language.
A local vector autoregressive framework and its applications to multivariate time series monitoring and forecasting

Our proposed local vector autoregressive (LVAR) model has time-varying parameters that allow it to be safely used in both stationary and non-stationary situations. The estimation is conducted over an interval of local homogeneity where the parameters are approximately constant. The local interval is identified in a sequential testing procedure. Numerical analysis and real data application are conducted to illustrate the monitoring function and forecast performance of the proposed model.
Accommodating the Newfound Strategic Importance of Educational Technologists within Higher Education: A Critical Literature Review

Purpose – Educational technologists make significant contributions to the development, organisational embedding and service provision of technology‐enhanced learning (TEL) environments, which are key enablers for mass access to flexible higher education (HE). Given the increasing centrality of this role, it is advocated that institutions investigate sustainable career structures for educational technologists. This paper aims to address these issues.Design/methodology/approach – The arguments are evidence‐driven by the small body of research literature describing the role of educational technologists and contextualized by the experiences as academics and leaders of TEL projects in HE, including managing educational technologists.Findings – The roles of educational technologists are very diverse, requiring competencies in educational leadership, both management and technical. Their career paths, backgrounds, legitimate powers and organisational locations exhibit considerable variation.Research limitations/i.
Dissecting the Biochemical and Transcriptomic Effects of a Locally Applied Heat Treatment on Developing Cabernet Sauvignon Grape Berries

Reproductive development of grapevine and berry composition are both strongly influenced by temperature. To date, the molecular mechanisms involved in grapevine berries response to high temperatures are poorly understood. Unlike recent data that addressed the effects on berry development of elevated temperatures applied at the whole plant level, the present work particularly focuses on the fruit responses triggered by direct exposure to heat treatment (HT). In the context of climate change, this work focusing on temperature effect at the microclimate level is of particular interest as it can help to better understand the consequences of leaf removal (a common viticultural practice) on berry development. HT (+ 8°C) was locally applied to clusters from Cabernet Sauvignon fruiting cuttings at three different developmental stages (middle green, veraison and middle ripening). Samples were collected 1, 7, and 14 days after treatment and used for metabolic and transcriptomic analyses. The results showed dramatic and specific biochemical and transcriptomic changes in heat exposed berries, depending on the developmental stage and the stress duration. When applied at the herbaceous stage, HT delayed the onset of veraison. Heating also strongly altered the berry concentration of amino acids and organic acids (e.g., phenylalanine, γ-aminobutyric acid and malate) and decreased the anthocyanin content at maturity. These physiological alterations could be partly explained by the deep remodeling of transcriptome in heated berries. More than 7000 genes were deregulated in at least one of the nine experimental conditions. The most affected processes belong to the categories “stress responses,” “protein metabolism” and “secondary metabolism,” highlighting the intrinsic capacity of grape berries to perceive HT and to build adaptive responses. Additionally, important changes in processes related to “transport,” “hormone” and “cell wall” might contribute to the postponing of veraison. Finally, opposite effects depending on heating duration were observed for genes encoding enzymes of the general phenylpropanoid pathway, suggesting that the HT-induced decrease in anthocyanin content may result from a combination of transcript abundance and product degradation.
The mental health of US Black women: the roles of social context and severe intimate partner violence

Objective Black women continue to have rates of mental health conditions that can be negative for their well-being. This study examined the contribution of social and contextual factors and severe physical intimate partner violence on the mental health of US Black women (African-American and Caribbean Black). Setting Data were largely collected via in-person community interviews at participants’ homes. Participants We studied 3277 African-American and Black Caribbean women from the 2001–2003 National Survey of American Life (NSAL), the largest and most complete sample of Blacks residing in the USA. Primary and secondary outcomes Key outcomes included an array of psychiatric disorders based on the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). Results Bivariate results revealed noticeably high rates of any anxiety disorder, post-traumatic stress disorder, any substance disorder, alcohol abuse disorder, suicide ideation and attempts, and any overall mental disorder among African-American women relative to Caribbean Black women. Multiple social and contextual factors were associated with various mental disorders among both sets of Black women in multivariate models, with the most consistent associations found for severe physical intimate partner violence. Everyday discrimination was associated with anxiety disorders (95% AOR=2.08 CI 1.23 to 3.51), eating disorders (95% AOR=2.69 CI 1.38 to 5.22), and any disorder (95% AOR=2.18 CI 1.40 to 3.40), while neighbourhood drug problems contributed to mood (95% AOR=1.19 CI 1.04 to 1.36), substance disorders (95% AOR=1.37 CI 1.11 to 1.69) and any disorder (95% AOR=1.18 CI 1.03 to 1.34). Conclusions Severe physical intimate partner violence, discrimination, and to a lesser extent, neighbourhood problems are important predictors of Black women's health, findings that inform intervention and clinical services tailored to meet the needs of Black women from diverse ethnic and cultural backgrounds.
Related Queries Recommendation Based on User Logs for Chinese Search Engines

This paper presents an effective method to suggest a list of semantically related queries to a given query submitted to a search engine. The related queries are based on previous queries in the user logs, and can be issued by the user to rephrase the search process. The method proposed is based on a query clustering process in which groups of semantically similar queries are identified. An efficient clustering algorithm called suffix tree clustering is developed in the study. Meanwhile, the keyword- based similarity measure is used for determining the closest cluster to the given query, and the Chinese synonymy is also considered in the measure to increase the veracity. To evaluate the proposed method, a series of experiments are carried out by using one month user logs from Chinese search engine Sogou. The performed experiments verify the effectiveness and efficiency of the method for query recommendation.
Analysis and Control Strategy for Relationship Risk in Manufacturer-Supplier Joint R&D

Manufacturer-supplier joint R&D basing on MICK resource integration is an effective method for new product development. However, the relationship risk in manufacturer-supplier joint R&D is particularly acute because the problems happened during the joint R&D such as different goals, uneven distribution of benefit, opportunism and so on. In this paper, relationship risk in manufacturer-supplier joint R&D basing on MICK resource integration was analyzed. Cognitive model of relationship risk was built up. In order to minimize the total relationship risk in risk area within the constraint of limited funds, the decision-making model of risk control was built up. The scientific decision-making method was raised to control the relationship risk in manufacturer-supplier joint R&D.
Cluster algorithm based on LDA model for public transport passengers' trip purpose identification in specific area

A better understanding of travel demand will enable transit authorities to evaluate the services they offer, adjust marketing strategies and improve overall transit performance. In this paper, we aim to develop a method to identify the trip purpose of passenger flow who have trips to commercial district. While the same region always has the different functions, it is fairly challenging to identify travel patterns for individual transit riders in a large dataset. To this end, we use the Latent Dirichlet Allocation algorithm to generate users' trip topic. And then, with the extraction of user topic distribution as the eigenvectors of the user, we cluster users into groups that have different trip purposes. The performance of the algorithm is compared with those of other prevailing classification algorithms. The results indicate that the proposed method outperforms other commonly used data-mining algorithms in terms of accuracy and efficiency.
Love Em Or Lose Em Getting Good People To Stay

love em or lose em getting good people to stay is available in our digital library an online access to it is set as public so you can download it instantly. Our book servers hosts in multiple countries, allowing you to get the most less latency time to download any of our books like this one. Kindly say, the love em or lose em getting good people to stay is universally compatible with any devices to read.
Multiple Relativistic Outbursts of GRS1915+105: Radio Emission and Internal Shocks

We present 5-GHz Multi-Element Radio-Linked Interferometer Network (MERLIN) radio images of the microquasar GRS 1915+105 during two separate outbursts in 2001 March and July, following the evolution of the jet components as they move outwards from the core of the system. Proper motions constrain the intrinsic jet speed to be >0.57c ,b ut the uncertainty in the source distance prevents an accurate determination of the jet speed. No deceleration is observed in the jet components out to an angular separation of ∼300 mas. Linear polarization is observed in the approaching jet component, with a gradual rotation in position angle and a decreasing fractional polarization with time. Our data lend support to the internal shock model whereby the jet velocity increases leading to internal shocks in the pre-existing outflow before the jet switches off. The compact nuclear jet is seen to reestablish itself within 2 d, and is visible as core emission at all epochs. The energetics of the source are calculated for the possible range of distances; a minimum power of 1‐10 per cent of the Eddington luminosity (LEdd )i srequired to launch the jet. Ke yw ords: accretion, accretion discs ‐ stars: individual: GRS 1915+105 ‐ stars: variables ‐ ISM: jets and outflows ‐ radio continuum: stars ‐ X-rays: stars.
Characterization of UV-enhanced SiPMs for imaging in a high pressure xenon electroluminescent TPC

The possibility of recording charged particle tracks in an electroluminescent xenon gas TPC is investigated using a SiPM-based tracking system, operated in the demonstrator prototype of the NEXT-100 ββ decay experiment. The tracks of the ββ0ν events from the decay of the 136Xe isotope have a distinctive topology, which allows their discrimination against single-electron events from the natural radioactivity that populates the region of interest of the neutrinoless decay in the ββ energy spectrum. Combined to the near-intrinsic energy resolution of the gaseous detector, this tracking capability provides a powerful background rejection tool for the search of the neutrinoless ββ decay aimed by the experiment. The NEXT-100 detector concepts and sensitivity and the first results of its demonstrator prototype are presented. The characterization studies relevant for the operation of UV-enhanced SiPMs used for imaging in an electroluminescent TPC are reviewed.