Miracle-dz/UniFAR-FTUs huggingface dataset:
Anti-HPV16 E2 Protein T-Cell Responses and Viral Control in Women with Usual Vulvar Intraepithelial Neoplasia and Their Healthy Partners

T-cell responses (proliferation, intracellular cytokine synthesis and IFNγ ELISPOT) against human papillomavirus 16 (HPV16) E2 peptides were tested during 18 months in a longitudinal study in eight women presenting with HPV16-related usual vulvar intraepithelial neoplasia (VIN) and their healthy male partners. In six women, anti-E2 proliferative responses and cytokine production (single IFNγ and/or dual IFNγ/IL2 and/or single IL2) by CD4+ T lymphocytes became detectable after treating and healing of the usual VIN. In the women presenting with persistent lesions despite therapy, no proliferation was observed. Anti-E2 proliferative responses were also observed with dual IFNγ/IL2 production by CD4+ T-cells in six male partners who did not exhibit any genital HPV-related diseases. Ex vivo IFNγ ELISPOT showed numerous effector T-cells producing IFNγ after stimulation by a dominant E2 peptide in all men and women. Since the E2 protein is absent from the viral particles but is required for viral DNA replication, these results suggest a recent infection with replicative HPV16 in male partners. The presence of polyfunctional anti-E2 T-cell responses in the blood of asymptomatic men unambiguously establishes HPV infection even without detectable lesions. These results, despite the small size of the studied group, provide an argument in favor of prophylactic HPV vaccination of young men in order to prevent HPV16 infection and viral transmission from men to women.
360° Innovations for Panoramic Video Streaming

360-degree videos are becoming increasingly popular on commercial platforms. In this position paper, we propose a holistic research agenda aiming at improving the performance, resource utilization efficiency, and users' quality of experience (QoE) for 360° video streaming on commodity mobile devices. Based on a Field-of-View (FoV) guided approach that fetches only portions of a scene that users will see, our proposed research includes the following: robust video rate adaptation with incremental chunk upgrading, big-data-assisted head movement prediction and rate adaptation, novel support for multipath streaming, and enhancements to live 360° video broadcast. We also show preliminary results demonstrating promising performance of our proof-of-concept 360° video streaming system on which our proposed research are being prototyped, integrated, and evaluated.
Low-frequency noise in bare SOI wafers: Experiments and model

Noise measurements are efficient for interface trap density characterization in MOSFETs and can be extended to bare silicon-on-insulator wafers. A physical model to explain the experimental results will be presented. The impact of measurement parameters, like die area and probe distance, is discussed comparing experimental and calculated characteristics. Important clarifications concerning the effective die area contributing to noise response will be pointed out.
Regulation of mitogen-activated protein kinase 3/1 activity during meiosis resumption in mammals

In vivo, resumption of oocyte meiosis occurs in large ovarian follicles after the preovulatory surge of luteinizing hormone (LH). The LH surge leads to the activation of a broad signaling network in mural granulosa cells equipped with LH receptors. The signals generated in the mural granulosa cells are further augmented by locally produced peptides or steroids and transferred to the cumulus cell compartment and the oocyte itself. Over the last decade, essential progress has been made in the identification of molecular events associated with the final maturation and ovulation of mammalian oocytes. All new evidence argues for a multiple roles of mitogen-activated protein kinase 3/1 (MAPK3/1) in the gonadotropin-induced ovulation processes. However, the knowledge of gonadotropin-induced signaling pathways leading to MAPK3/1 activation in follicular cells seems limited. To date, only the LH-induced transactivation of the epidermal growth factor receptor/MAPK3/1 pathway has been described in granulosa/cumulus cells even though other mechanisms of MAPK3/1 activation have been detected in other types of cells. In this review, we aimed to summarize recent advances in the elucidation of gonadotropin-induced mechanisms leading to the activation of MAPK3/1 in preovulatory follicles and cultured cumulus-oocyte complexes and to point out a specific role of this kinase in the processes accompanying final maturation of the mammalian oocyte.
Signal-Dependent Spatial Filtering Based on Weighted-Orthogonal Beamformers in the Spherical Harmonic Domain

Spatial filtering with microphone arrays is a technique that can be utilized to obtain the signal of a target sound source from a specific direction. Typical approaches in the field of audio underperform in practical environments with multiple sound sources and diffuse sound. In this contribution, we propose a postfiltering technique to suppress the effect of interferers and diffuse sound. The proposed technique utilizes the cross-spectral estimates of the output of two beamformers to formulate a time-frequency soft masker. The beamformers' outputs are used only for parameter estimation and not for generating an audio signal. Two sets of beamformer weights, a constant and an adaptive, are applied to the microphone array signals for the parameter estimation. The weights of the constant beamformer are designed such that they provide a spatially narrow beam pattern that is time and frequency invariant, having a unity gain toward the direction of interest. The weights of the adaptive beamformer are formulated using linearly constrained optimization with the constraint of weighted orthogonality with respect to the constant beamformer weights, as well as the unity gain toward the look direction. The orthogonality constraint provides diffuse sound suppression while the unity gain distortionless response. The cross spectrum of these two beamformers provides the target energy at a given look direction for the post filter. The study focuses on compact microphone arrays with which the typical beamforming techniques feature a tradeoff between noise amplification and spatial selectivity, especially in the low frequency region. The proposed method is evaluated with instrumental measures and listening tests under different reverberation times, in dual and multitalker scenarios. The evaluation shows that the proposed method provides a better performance when compared with a previous state-of-the-art spatial filter based on cross-pattern coherence, a linearly constrained beamformer and a Wiener postfilter.
Locations of the lip, poxB, and ilvBN genes on the physical map of Escherichia coli

The lip locus, located at ca. 14.5 min on the Escherichia coli chromosome (6), is thought to encode an enzyme (or enzymes) involved in the terminal step(s) of lipoic acid biosynthesis (1, 14). We have used a representative mutant (JRG26) from the single genetic class of lipoic acid-auxotro- phic strains described by Herbert and Guest (7) to identify the Kohara A phage which carries the complementing lip gene (Table 1). This phage also carries a DNA segment corresponding to a second genetic class of lipoic acid-auxotrophic mutants recently isolated in our laboratory (to be published elsewhere). Our restriction data from the lip locus are in general agreement with the data of Kohara et al. (9). However, we have not attempted to exhaustively verify the Kohara physical map of phage X168. Our and around The agrees (ilvBN is essentially restriction with
Outatime: Using Speculation to Enable Low-Latency Continuous Interaction for Mobile Cloud Gaming

Gaming on phones, tablets and laptops is very popular. Cloud gaming - where remote servers perform game execution and rendering on behalf of thin clients that simply send input and display output frames - promises any device the ability to play any game any time. Unfortunately, the reality is that wide-area network latencies are often prohibitive; cellular, Wi-Fi and even wired residential end host round trip times (RTTs) can exceed 100ms, a threshold above which many gamers tend to deem responsiveness unacceptable. In this paper, we present Outatime, a speculative execution system for mobile cloud gaming that is able to mask up to 120ms of network latency. Outatime renders speculative frames of future possible outcomes, delivering them to the client one entire RTT ahead of time, and recovers quickly from mis-speculations when they occur. Clients perceive little latency. To achieve this, Outatime combines: 1) future state prediction; 2) state approximation with image-based rendering and event time-shifting; 3) fast state checkpoint and rollback; and 4) state compression for bandwidth savings. To evaluate the Outatime speculation system, we use two high quality, commercially-released games: a twitch-based first person shooter, Doom 3, and an action role playing game, Fable 3. Through user studies and performance bench- marks, we find that players strongly prefer Outatime to traditional thin-client gaming where the network RTT is fully visible, and that Outatime successfully mimics playing across a low-latency network.
Postmortem circulation: A new model for testing endovascular devices and training clinicians in their use

The development of new medical devices, such as aortic valves, requires numerous preliminary studies on animals and training of personnel on cadavers before the devices can be used in patients. Postmortem circulation, a technique used for postmortem angiography, allows the vascular system to be reperfused in a way similar to that in living persons. This technique is used for postmortem investigations to visualize the human vascular system and to make vascular diagnoses. Specific material for reperfusing a human body was developed recently. Our aim was to investigate whether postmortem circulation that imitates in vivo conditions allows for the testing of medical materials on cadavers. We did this by delivering an aortic valve using minimally invasive methods. Postmortem circulation was established in eight corpses to recreate an environment as close as possible to in vivo conditions. Mobile fluoroscopy and a percutaneous catheterization technique were used to deliver the material to the correct place. Once the valve was implanted, the heart and primary vessels were extracted to confirm its position. Postmortem circulation proved to be essential in several of the cadavers because it helped the clinicians to deliver the material and improve their implantation techniques. Due to the intravascular circulation, sites with substantial arteriosclerotic stenosis could be bypassed, which would have been impossible without perfusion. Although originally developed for postmortem investigations, this reperfusion technique could be useful for testing new medical devices intended for living patients. Clin. Anat. 556–562, 2014. © 2013 Wiley Periodicals, Inc.
Performance-driven evolutionary capabilities in virtual production ecosystems

This paper examines possible aids of performance measurement to the evolution in 5 production ecosystems. A conceptual solution is proposed which derives from the potential of 6 exponential technologies, theory and practice. By adopting an ecosystem approach, a twofold 7 setup of performance has been designed that addresses both the performance of actors and the 8 performance of ecosystem. The proposed mechanism applies Big Data and machine learning. 9 The proof of concept was supported by a prototype of the virtual environment. 10
Vitamin D and Autoimmune Disease

During the past decade, important advances in the study of vitamin D have been made as vitamin D insufficiency is emerging as a clinical problem at a global level. In addition to its important role in skeletal development and maintenance, evidence is mounting that vitamin D produce beneficial effect on extraskeletal tissues. Recent evidence shows that vitamin D deficiencies contribute autoimmune diseases susceptibility and severity. This chapter will provide a systematic review of the importance of vitamin D in preexisting autoimmune diseases and whether its deficiency predispose patients to such disorders.
A flexible framework for key audio effects detection and auditory context inference

Key audio effects are those special effects that play critical roles in human's perception of an auditory context in audiovisual materials. Based on key audio effects, high-level semantic inference can be carried out to facilitate various content-based analysis applications, such as highlight extraction and video summarization. In this paper, a flexible framework is proposed for key audio effect detection in a continuous audio stream, as well as for the semantic inference of an auditory context. In the proposed framework, key audio effects and the background sounds are comprehensively modeled with hidden Markov models, and a Grammar Network is proposed to connect various models to fully explore the transitions among them. Moreover, a set of new spectral features are employed to improve the representation of each audio effect and the discrimination among various effects. The framework is convenient to add or remove target audio effects in various applications. Based on the obtained key effect sequence, a Bayesian network-based approach is proposed to further discover the high-level semantics of an auditory context by integrating prior knowledge and statistical learning. Evaluations on 12 h of audio data indicate that the proposed framework can achieve satisfying results, both on key audio effect detection and auditory context inference.
The discovery and distribution of Aedes albopictus in Harris County, Texas.

On August 2, 1985, numerous adults and larvae of an unknown species of Aedes were collected from several widely separated tire dumps, in and around the city of Houston, Texas. Specimens sent to Dr. Y. -M. Huang at the U. S. National Museum, were identified as Aedes albopictru (Skuse), a container-breeding species, indigenous to the Oriental and Australian regions. Aedes albopictu.r has been collected three times previously in the United States (Pratt et al. 1946, Eads 1972, Reiter and Darsie 1984), but this is the first record of breeding populat ions establ ished in the continental United States. A survey of Harris County was begun on August 22 to determine the frequency, abundance and distribution of Ae. albopictus in water-filled cbntainers, especially tires. Organization of the survey was based upon the coded system of sectors used by the Harris County Mosquito Control District to identify specific regions within the county. Under this system, Harris County is divided into 268 sectors' averaging 6.6 square miles. OnceAe. albopictus was found breeding on a site, we considered the entire sector in which the sample was taken to contain Ae. albopicnu. We then proceeded to survey the next successive sector. In this way, the 1,765 square miles of the county could be surveyed in a minimal amount of time. The survey was completed on October ll, with 178 (66.4Va\ of the sectors from all parts of the county being investigated. Twenty-three water-filled containers and 166 used tires were found with mosquito larvae of 8 different species (Table l). Surprisingly, Ae. albopictus was both the most abundant and frequently collected species. Aedes albopicrur was found in 125
Malabsorption of modified food starch (acetylated distarch phosphate) in normal infants and in 8–24‐month‐old toddlers with non‐specific diarrhea, as influenced by sorbitol and fructose

Acetylated distarch phosphate (ADiSP) is a modified starch used in some baby foods. The bioavailability of ADiSP and a native (unmodified) starch was evaluated in 20 normal infants and 21 toddlers aged 8–24 mo with chronic non‐specific diarrhea. Formulae contained 8% native or 8% modified waxy maize starch. No infant or toddler consuming Formula N (native starch) had elevated peak breath hydrogen levels (20 ppm or greater), stools clinically positive for reducing substances (0.75% or greater) or loose stools. Fourteen infants received formula M (modified starch): 2 had elevated breath hydrogen, 1 had positive stools and another had loose stools. Of the 21 toddlers fed formula M, 2 had elevated breath hydrogen, but none had positive stools or loose stools. Formula NS (native starch with 2% sorbitol) had little effect on breath hydrogen in the infants but significantly increased it in the toddlers. Formula NS produced loose stools in 2 toddlers but no clinically positive stools in any infant or toddler. Formula MS (modified starch with 2% sorbitol) elevated breath hydrogen in 3 infants and 8 toddlers, and produced positive stools in 2 infants and 2 toddlers, and loose stools in 4 infants and 7 toddlers. Formula MSF (modified starch with 2% sorbitol and 5% fructose) elevated breath hydrogen in 7 infants and 10 toddlers, positive stools in 7 infants and 6 toddlers, and loose stools or diarrhea in 7 infants and 11 toddlers.
Suppression of v-src Transformation by the drs Gene

ABSTRACT Previously, we isolated a novel gene, drs, which was downregulated by retroviral oncogenes such as v-src and v-K-ras, from a cDNA library of primary rat embryo fibroblasts. Experiments using a temperature-sensitive mutant of the v-src gene indicated that downregulation of drsmRNA was dependent on functional expression of v-Src. In addition, expression of drs mRNA was also reduced by serum stimulation of G0-arrested normal rat fibroblast cells. To clarify the function of the drs gene in cell transformation and proliferation, we introduced drs linked to a potent promoter into a normal rat cell line, F2408, and examined the effect of ectopic expression of exogenous drs on the transformation by the v-src gene and growth properties. Cells expressing exogenous drs gene showed significantly decreased efficiency of transformation by v-src irrespective of functional expression of v-Src kinase, while the growth rate and G1/S progression of the cells were not suppressed by expression of exogenous drs gene, indicating thatdrs has the ability to suppress v-srctransformation without disturbing cell proliferation.
Functional and topological characteristics of mammalian regulatory domains

Long-range regulatory interactions play an important role in shaping gene-expression programs. However, the genomic features that organize these activities are still poorly characterized. We conducted a large operational analysis to chart the distribution of gene regulatory activities along the mouse genome, using hundreds of insertions of a regulatory sensor. We found that enhancers distribute their activities along broad regions and not in a gene-centric manner, defining large regulatory domains. Remarkably, these domains correlate strongly with the recently described TADs, which partition the genome into distinct self-interacting blocks. Different features, including specific repeats and CTCF-binding sites, correlate with the transition zones separating regulatory domains, and may help to further organize promiscuously distributed regulatory influences within large domains. These findings support a model of genomic organization where TADs confine regulatory activities to specific but large regulatory domains, contributing to the establishment of specific gene expression profiles.
Trade-Offs in Exploiting Body Morphology for Control: from Simple Bodies and Model-Based Control to Complex Bodies with Model-Free Distributed Control Schemes

Tailoring the design of robot bodies for control purposes is implicitly performed by engineers, however, a methodology or set of tools is largely absent and optimization of morphology (shape, material properties of robot bodies, etc.) is lagging behind the development of controllers. This has become even more prominent with the advent of compliant, deformable or "soft" bodies. These carry substantial potential regarding their exploitation for control---sometimes referred to as "morphological computation" in the sense of offloading computation needed for control to the body. Here, we will argue in favor of a dynamical systems rather than computational perspective on the problem. Then, we will look at the pros and cons of simple vs. complex bodies, critically reviewing the attractive notion of "soft" bodies automatically taking over control tasks. We will address another key dimension of the design space---whether model-based control should be used and to what extent it is feasible to develop faithful models for different morphologies.
Comparative proteomic analysis of proteins expression changes in the mammary tissue of cows infected with Escherichia coli mastitis

Cows infected with Escherichia (E.) coli usually experience severe clinical symptoms, including damage to mammary tissues, reduced milk yield, and altered milk composition. In order to investigate the host response to E. coli infection and discover novel markers for mastitis treatment, mammary tissue samples were collected from healthy cows and bovines with naturally occurring severe E. coli mastitis. Changes of mammary tissue proteins were examined using two-dimensional gel electrophoresis and label-free proteomic approaches. A total of 95 differentially expressed proteins were identified. Of these, 56 proteins were categorized according to molecular function, cellular component, and biological processes. The most frequent biological processes influenced by the proteins were response to stress, transport, and establishment of localization. Furthermore, a network analysis of the proteins with altered expression in mammary tissues demonstrated that these factors are predominantly involved with binding and structural molecule activities. Vimentin and α-enolase were central "functional hubs" in the network. Based on results from the present study, disease-induced alterations of protein expression in mammary glands and potential markers for the effective treatment of E. coli mastitis were identified. These data have also helped elucidate defense mechanisms that protect the mammary glands and promote the pathogenesis of E. coli mastitis.
Towards Quantum Language Models

This paper presents a new approach for building Language Models using the Quantum Probability Theory, a Quantum Language Model (QLM). It mainly shows that relying on this probability calculus it is possible to build stochastic models able to benefit from quantum correlations due to interference and entanglement. We extensively tested our approach showing its superior performances, both in terms of model perplexity and inserting it into an automatic speech recognition evaluation setting, when compared with state-of-the-art language modelling techniques.
Understanding and Predicting Protein Assemblies With 3D Structures

Protein interactions are central to most biological processes, and are currently the subject of great interest. Yet despite the many recently developed methods for interaction discovery, little attention has been paid to one of the best sources of data: complexes of known three-dimensional (3D) structure. Here we discuss how such complexes can be used to study and predict protein interactions and complexes, and to interrogate interaction networks proposed by methods such as two-hybrid screens or affinity purifications.
Effect of circuit switched services on the capacity of HSDPA

This paper focuses on the effect of circuit switched (CS) services on high speed downlink packet access (HSDPA) packet services in the context of the UMTS FDD system. An objective of the analysis is to provide guidelines for the UMTS planning process to prioritize services when resources are dynamically shared between circuit and packet services. An analytical model, taking into account some of the features introduced in HSDPA (namely adaptive modulation and coding (AMC), hybrid automatic repeat request (HARQ) and fast cell selection) and the interaction between CS services and HSDPA, is proposed to approximate the HSDPA cell capacity. Simulation results to assess the efficiency of the analytical model are also reported.