Miracle-dz/UniFAR-FTUs huggingface dataset:
Benefit of a high-dose epirubicin regimen in adjuvant chemotherapy for node-positive breast cancer patients with poor prognostic factors: 5-year follow-up results of French Adjuvant Study Group 05 randomized trial.

PURPOSE To determine the influence of the epirubicin dose in operable node-positive breast cancer patients with factors of poor prognosis. PATIENTS AND METHODS Between April 1990 and July 1993, 565 operable breast cancer patients with either more than three positive nodes or between one and three positive nodes with Scarff Bloom Richardson grade > or = 2 and hormone receptor negativity were randomized after surgery to receive either fluorouracil 500 mg/m(2), epirubicin 50 mg/m(2), and cyclophosphamide 500 mg/m(2) every 21 days for six cycles (FEC 50) or the same regimen except with epirubicin dose of 100 mg/m(2) (FEC 100). Postmenopausal patients received tamoxifen 30 mg/d for 3 years at the beginning of chemotherapy. Radiotherapy was delivered at the end of chemotherapy in both groups. RESULTS The median follow-up was 67 months. The 5-year disease-free survival (DFS) was 54.8% with FEC 50 and 66.3% with FEC 100 (P =.03). The 5-year overall survival (OS) was 65.3% and 77.4%, respectively (P =.007). The mean relative dose-intensity was similar in the two groups (90.3% and 86.1%, respectively). Neutropenia and anemia were significantly more frequent in FEC 100 (P < 10(-3)), as were nausea-vomiting (P =.008) and stomatitis and alopecia (P < 10(-3)). Nine cases of grade 3 infection occurred only with FEC 100, and no toxic deaths occurred. Three cases of acute cardiac toxicity were observed (FEC50 = 1, FEC100 = 2) and 10 patients (FEC50 = 6, FEC100 = 4) presented delayed cardiac dysfunctions. Two cases of secondary leukemia were observed (acute lymphatic leukemia with FEC 50 and acute myelogenous leukemia with FEC 100). CONCLUSION After 5 years of follow-up, the increased epirubicin dose led to a significant benefit in terms of DFS and OS, with a high survival rate among patients with poor-prognosis breast cancer.
Study of Tin Whisker Growth and their Mechanical and Electrical Properties

The phenomenon of spontaneous growth of metallic filaments, known as whisker growth has been studied. Until now the problem that Sn whisker growth could cause in electronics by making shorts has been partially prohibited as Pb and Sn have been used together in solders and coating. Regulations restricting Pb use in electronics has made the need to understand Sn whisker growth more current.It is shown that whiskers are highly resilient towards vibrations and shocks. A Sn whisker is shown to withstand 55 mA.Results show that reflowing of the Sn plated surface does not prevent extensive whisker growth. Results show that intermetallic compound growth can not be the sole reason behind whisker growth. Nickel and silver underlayer have been shown not to prevent whisker growth, but perhaps restrain whisker growth. Heat treatment damped whisker growth considerably. It is judged that base material CuSn6 is less prone to show whisker growth than CuSn0.15 and E-Cu58.
Seeing the world topsy-turvy: The primary role of kinematics in biological motion inversion effects

Physical inversion of whole or partial human body representations typically has catastrophic consequences on the observer's ability to perform visual processing tasks. Explanations usually focus on the effects of inversion on the visual system's ability to exploit configural or structural relationships, but more recently have also implicated motion or kinematic cue processing. Here, we systematically tested the role of both on perceptions of sex from upright and inverted point-light walkers. Our data suggest that inversion results in systematic degradations of the processing of kinematic cues. Specifically and intriguingly, they reveal sex-based kinematic differences: Kinematics characteristic of females generally are resistant to inversion effects, while those of males drive systematic sex misperceptions. Implications of the findings are discussed.
A family-based intervention to increase consumption of starchy foods.

The UK public has been fairly resistant to health promotion messages encouraging reduced fat intake as a component of the strategy to help achieve the targets for cardiovascular disease risk reduction identified in The Health of the Nation and extended in Saving Lives: Our Healthier Nation. This project is designed to test the hypothesis that a more positive message to eat more (low fat) starchy foods would be better received and achieve the desired dietary goals. Newcastle families, in enumeration districts in the middle three quintiles of the Townsend Deprivation Index who do not meet current dietary targets for fat and starch, are being recruited to one of three interventions designed to encourage and enable them to choose diets richer in starchy foods. Dietary outcomes are being measured at three and six months after the interventions. We are investigating the process of change through use of questionnaires and in‐depth interviews with both “achievers” and “non‐achievers”.
Allochronic differentiation among Daphnia species, hybrids and backcrosses: the importance of sexual reproduction for population dynamics and genetic architecture

Seasonal dynamics of the abundance, sexual reproduction and genetic architecture in a Daphnia hyalina‐galeata hybrid complex were studied in the large and deep Lake Constance. We found evidence for the occurrence of first and second order hybridization. Our study revealed strong differences between the parental species not only regarding their seasonal dynamics, genetic architecture and diversity, but also their sexual reproductive behaviour. The overwintering D. hyalina showed low genetic diversity, no genetic differentiation during the season, and reproduced sexually in autumn, whereas D. galeata reached higher levels of genetic diversity, reproduced sexually in early summer, and exhibited changes in genetic structure during the season, but was only present from spring to autumn. However, in both species sexual reproduction was a rare event, and daphnids, including hybrids, reproduced predominantly asexually. This allows long‐term persistence of hybrids as well without continuing hybridization events. Within all variables studied, F1 and F2 hybrids showed an intermediate pattern, whereas proposed backcross hybrids were more similar to their respective parentals. These differences in phenotype as well as significant differences in pairwise Fst values between parentals suggest that gene flow seems to be relatively low in the Lake Constance hybrid system. We found evidence for unidirectional introgression by backcrossing from D. galeata to D. hyalina and found a decrease in at least one of the proposed introgressed alleles in the hyalina‐backcross while the season progressed. Our findings suggest allochronic differentiation within this hybrid population and different microevolutionary trajectories of the parental species, which will be discussed in the light of the ongoing reoligotrophication process of Lake Constance.
A taxonomy of branch mispredictions, and alloyed prediction as a robust solution to wrong-history mispredictions

The need for accurate conditional-branch prediction is well known: mispredictions waste large numbers of cycles, inhibit out-of-order execution, and waste power on mis-speculated computation. Prior work on branch-predictor organization has focused mainly on how to reduce conflicts in the branch-predictor structures, while relatively little work has explored other causes of mispredictions. Some prior work has identified other categories of mispredictions, but this paper organizes these categories into a broad taxonomy of misprediction types. Using the taxonomy, this paper goes on to show that other categories- especially wrong history mispredictions-are often more important than conflicts. This is true even if just a very simple conflict-reduction technique is used. Based on these observations, this paper proposes alloying local and global history together in a two-level branch predictor structure. This simple technique, a generalization of the bi-mode predictor, attacks wrong-history mispredictions by making both global and local history simultaneously available. Unlike bi-mode prediction, however, alloying gives robust performance for branch-predictor hardware budgets ranging from very large to very small. Finally, this paper shows that individual branch references can also suffer wrong-history mispredictions as they alternate between using global and local history, a phenomenon that favors dynamic rather than static selection in hybrid predictors.
Intrusion errors in visuospatial working memory performance

This study tested the hypothesis that failure in active visuospatial working memory tasks involves a difficulty in avoiding intrusions due to information that is already activated. Two experiments are described, in which participants were required to process several series of locations on a 4 × 4 matrix and then to produce only the final location of each series. Results revealed a higher number of errors due to already activated locations (intrusions) compared with errors due to new locations (inventions). Moreover, when participants were required to pay extra attention to some irrelevant (non-final) locations by tapping on the table, intrusion errors increased. Results are discussed in terms of current models of working memory functioning.
Hydrodynamic effects on the origin and quality of organic matter for bivalves: an integrated isotopic, biochemical and transplant study

Different hydrodynamic conditions can affect both the origin and the quality of organic matter available to bivalve molluscs. I chose 2 environments with very different hydrodynamics (a Mediterranean lagoon open to flow and a closed pond), but similar with regard to temperature, salinity, depth, wind exposure and algae coverage, to investigate this. The lagoon was characterised by active flow and bivalve molluscs, whereas the pond was closed off from the lagoon’s main flow but characterised by mussel beds of the highest density ever observed in the western Mediterranean. Biochemical features, 13C and 15N contents of particulate and sedimentary organic matter, and isotopic signatures of dominant organisms, were used as descriptors of the trophodynamics in both systems. In the lagoon, intense lateral drifting forces moved organic matter far from production sites, thereby depleting the water column of resuspended sedimentary organic matter. In the pond, winddriven conditions enhanced the coupling between the water column and the sediments, enriching the pond with resuspended sedimentary products. Integrating results, it was deduced that mussels in the pond could exploit, over time, organic matter produced in loco, continually rearranged in loco by means of wind-driven resuspension and consumed in loco with an efficiency able to sustain a massive secondary production. In contrast, under lagoon conditions, the benthic and pelagic habitats were uncoupled, so that each had its own independent status with its own dynamics and production. This reduced the suitability of this habitat for high levels of secondary production.
Harmonic-Temporal Clustering of Speech for Single and Multiple F0 Contour Estimation in Noisy Environments

We present in this paper a novel F0 contour estimation method based on a parametric description of the wavelet power spectrum of speech that accounts for its structure simultaneously in time and frequency directions. We model the speech spectrum as a sequence of spectral clusters governed by a smooth common F0 contour expressed as a spline curve. The harmonic and temporal structure of these clusters and their common F0 contour are estimated simultaneously. Through experimental comparisons with existing methods, we show that our algorithm is competitive on clean single-speaker speech, and that it outperforms existing methods both in the presence of noise and for the estimation of multiple F0 contours of cochannel concurrent speech.
The Producing Technology of Resistant Starch (RS) from Buckwheat Using Microwave Treatment

Resistant Starch (RS) has various functions in controlling the Glycemic Index (GI), lowering concentration of cholesterol and triglycerides, inhibiting fat accumulation, preventing colonic cancer, reducing gall stone formation, maintaining intestinal tract healthy and enhancing the absorption of minerals. Elevated RS in food is an important and effective approach for public health. RS is also an important material for industries. In this paper, the producing technologies of resistant starch from buckwheat were investigated. The results showed that the optimum parameters for producing technology of resistant starch from buckwheat using microwave treatment are microwave power at 540W, treatment time is 120s, Solid-to-liquid ratio 1:3, cold storage time 24h.
Risk factors for autism and Asperger syndrome

Using the Swedish Medical Birth Registry (MBR), obstetrical and demographic information was retrieved for 250 children with autism or Asperger syndrome who were born in Malmoe, Sweden, and enrolled at the local Child and Youth Habilitation Center. The reference group consisted of all children born in Malmoe during 1980—2005. Obstetric sub-optimality (prematurity, low Apgar scores, growth restriction, or macrosomia) was positively associated with autism but not with Asperger syndrome. Maternal birth outside the Nordic countries was positively associated with autism (adjusted OR: 2.2; 95%CI: 1.6—3.1) and negatively associated with Asperger syndrome (OR: 0.6; 95%CI: 0.3—0.97). The highest risk estimate for autism was found among children to women who were born in sub-Saharan Africa (OR: 7.3), or in East Asia (OR: 3.4).
DMTCP: Transparent checkpointing for cluster computations and the desktop

DMTCP (distributed multithreaded checkpointing) is a transparent user-level checkpointing package for distributed applications. Checkpointing and restart is demonstrated for a wide range of over 20 well known applications, including MATLAB, Python, TightVNC, MPICH2, OpenMPI, and runCMS. RunCMS runs as a 680 MB image in memory that includes 540 dynamic libraries, and is used for the CMS experiment of the Large Hadron Collider at CERN. DMTCP transparently checkpoints general cluster computations consisting of many nodes, processes, and threads; as well as typical desktop applications. On 128 distributed cores (32 nodes), checkpoint and restart times are typically 2 seconds, with negligible run-time overhead. Typical checkpoint times are reduced to 0.2 seconds when using forked checkpointing. Experimental results show that checkpoint time remains nearly constant as the number of nodes increases on a medium-size cluster. DMTCP automatically accounts for fork, exec, ssh, mutexes/ semaphores, TCP/IP sockets, UNIX domain sockets, pipes, ptys (pseudo-terminals), terminal modes, ownership of controlling terminals, signal handlers, open file descriptors, shared open file descriptors, I/O (including the readline library), shared memory (via mmap), parent-child process relationships, pid virtualization, and other operating system artifacts. By emphasizing an unprivileged, user-space approach, compatibility is maintained across Linux kernels from 2.6. 9 through the current 2.6. 28. Since DMTCP is unprivileged and does not require special kernel modules or kernel patches, DMTCP can be incorporated and distributed as a checkpoint-restart module within some larger package.
Protective Effects of HBSP on Ischemia Reperfusion and Cyclosporine A Induced Renal Injury

Ischemia reperfusion (IR) and cyclosporine A (CsA) injuries are unavoidable in kidney transplantation and are associated with allograft dysfunction. Herein, the effect and mechanism of a novel tissue protective peptide, helix B surface peptide (HBSP) derived from erythropoietin, were investigated in a rat model. The right kidney was subjected to 45 min ischemia, followed by left nephrectomy and 2-week reperfusion, with or without daily treatment of CsA 25 mg/kg and/or HBSP 8 nmol/kg. Blood urea nitrogen was increased by CsA but decreased by HBSP at 1 week and 2 weeks, while the same changes were revealed in urinary protein/creatinine only at 2 weeks. HBSP also significantly ameliorated tubulointerstitial damage and interstitial fibrosis, which were gradually increased by IR and CsA. In addition, apoptotic cells, infiltrated inflammatory cells, and active caspase-3+ cells were greatly reduced by HBSP in the both IR and IR + CsA groups. The 17 kD active caspase-3 protein was decreased by HBSP in the IR and IR + CsA kidneys, with decreased mRNA only in the IR + CsA kidneys. Taken together, it has been demonstrated, for the first time, that HBSP effectively improved renal function and tissue damage caused by IR and/or CsA, which might be through reducing caspase-3 activation and synthesis, apoptosis, and inflammation.
Retrospective success and survival rates of dental implants placed after a ridge preservation procedure

AIM Ridge preservation is any procedure that takes place at the time of, or shortly after an extraction, to minimise resorption of the ridge and maximise bone formation within the socket. The aim of this project is to investigate the outcome of implant treatment following ridge preservation and compare it to an ungrafted implant control group. METHODS AND MATERIALS Following ethics approval, an electronic and manual search of patient records was conducted, and appropriate cases of implant placement following a ridge preservation procedure were identified. Forty-two patients with 51 implants at ridge-preserved sites were examined by one author (PA) with the following parameters assessed at each implant: pocket probing depth, bleeding on probing, presence/absence of plaque and radiographic bone loss. Clinical and radiographic findings were compared to an ungrafted implant control group and analysed by years in function. RESULTS There was a 100% survival rate of implants in ridge-preserved sites. In the majority of cases, ridge preservation was performed in the anterior maxilla with a flap raised and the use of deproteinised bovine bone mineral and collagen membrane materials. The mean time in function was 31 (±24) months with a range of 2-102 months. Differences in the mean PPD, BOP, plaque index and radiographic bone loss were not statistically significant between implants at ridge-preserved or ungrafted sites. The overall success rate was around 58% for ungrafted implants and around 51% for implants in ridge-preserved sites. However, this difference was not statistically significant. CONCLUSION In this retrospective study, implant placement at ridge-preserved sites was a predictable procedure that led to very high survival rates and similar success rates to implant placement at ungrafted sites.
Quantitative analysis of the temporal pattern of somite formation in the mouse and rat. A simple and accurate method for age determination.

The relation between the logarithm of the volume of the embryo and the number of somites was studied in the mouse and rat in the period of about 0-43 somites, a period characterized by a very rapid volume increase. A linear relation was found, and the variability of the individual observations around the straight line was rather small. Using a previously defined age estimate, i.e. the 'developmental age' based on the embryonic volume, we also found a linear relation between this age estimate and the number of somites. With the help of this straight line, the developmental age can be estimated from the number of somites with an accuracy of less than 0.1 day. Therefore, the developmental age can be considered a better age estimate than those based on the usual methods. The time needed to form a new somite was found to be constant in both species during the period studied. The length of the period differed, and was 1.68 h in the mouse and 2.24 h in the rat. However, the volume of the embryo at the time when a specific somite was formed (for instance the 25th) appeared to be the same in both species. Comparison of the volume of embryos, embedded in paraffin and Epon and sectioned, enabled us to estimate the shrinkage in Epon embryos. The volume after processing was approximately 62% of the original volume.
Extraocular Motor Unit and Whole-Muscle Responses in the Lateral Rectus Muscle of the Squirrel Monkey

Because primate studies provide data for the current experimental models of the human oculomotor system, we investigated the relationship of lateral rectus muscle motoneuron firing to muscle unit contractile characteristics in the squirrel monkey. Also examined was the correlation of whole-muscle contractile force with the degree of evoked eye displacement. A force transducer was used to record lateral rectus whole-muscle or muscle unit contraction in response to abducens whole-nerve stimulation or stimulation of single abducens motoneurons or axons. Horizontal eye displacement was recorded using a magnetic search coil. (1) Motor units could be categorized based on contraction speed (fusion frequency) and fatigue. (2) The kt value (change in motoneuronal firing necessary to increase motor unit force by 1.0 mg) of the units correlated with maximum tetanic tension. (3) There was some tendency for maximum tetanic tension of this unit population to separate into three groups. (4) At a constant frequency of 100 Hz, 95% of the motor units demonstrated significantly different force levels dependent on immediately previous stimulation history (hysteresis). (5) A mean force change of 0.32 gm/° and a mean frequency change of 4.7 Hz/° of eye displacement were observed in response to whole-nerve stimulation. These quantitative data provide the first contractile measures of primate extraocular motor units. Models of eye movement dynamics may need to consider the nonlinear transformations observed between stimulation rate and muscle tension as well as the probability that as few as two to three motor units can deviate the eye 1°.
Answer extraction based on query expansion in Chinese question answering system

When using natural language question to retrieval document, query expansion are the key factors that affect its retrieval performance. By analyzing the traditional query expansion method, this paper puts forward a query expansion method based on set theory for answering document retrieval. In order to verify the validity of the method, a similarity calculation method for question and candidate answer sentences is proposed to extract the answer. The major query expansion terms and the minor query expansion terms are taken into consideration with different weight in the similarity calculation. The experiment results show that the performance makes substantial improvement.
Comparing methods of ECG respiration signals derivation based on measuring the amplitude of QRS complexes

This paper presents the study of algorithms for derivation of respiration waveform from the electrocardiogram. The problem has considerable clinical impact, because the heart rate and respiration are both driven by the central nervous system, and commonly used low-cost Holter recording may be used for efficient detection of breath disturbances (e.g. apnea). Three methods based on: heart rate, heart position and lung resistance influencing the ECG amplitude were compared in our research. Among 18 volunteers breathing at a controlled frequency all implemented algorithms show acceptable sensitivity of order of 97% in slow breathing phases detection. In fast breathing the sensitivity is reduced to 90%, since the heart beats are too sparse with regard of respiration waveform.
TwistMouse for simultaneous translation and rotation

We propose a mouse input device, the TwistMouse, with three degrees of freedom: horizontal (x), vertical (y) and rotational (z) for simultaneous translation and rotation of on-screen objects. We describe the construction of a prototype device and present a usability evaluation to investigate the appropriateness of the twist mode for positioning 2D objects on screen.