Miracle-dz/UniFAR-FTUs huggingface dataset:
Facing the Challenge of Character Education.

Following every unfortunate and tragic school shooting is an accompanying cry for moral/character/values education, in the belief that such teaching could have prevented the tragedy. We decry the rising statistical evidence of the apparent lack of values and character demonstrated by youth as evidenced by soaring crime rates among very young age groups, rampant abuse of drugs, open displays of cruelty, and a generalized display of disrespect. Various social institutions, namely parents and schools, are pointing the finger of blame at each other instead of jointly assuming responsibility for the task of character education. The need for character education is certainly not being denied, but the public—and indeed many current educators—is seemingly unaware that such education has a long and definitive history. Lost in the midst of that history is not the attempt to reach consensus on whether the family, or the school or both should teach it, but rather the meaning of character education itself, the initiatives for doing so, and the ultimate evaluation of those initiatives.
The F-BAR Protein NOSTRIN Dictates the Localization of the Muscarinic M3 Receptor and Regulates Cardiovascular Function.

RATIONALE Endothelial dysfunction is an early event in cardiovascular disease and characterized by reduced production of nitric oxide (NO). The F-BAR protein NO synthase traffic inducer (NOSTRIN) is an interaction partner of endothelial NO synthase and modulates its subcellular localization, but the role of NOSTRIN in pathophysiology in vivo is unclear. OBJECTIVE We analyzed the consequences of deleting the NOSTRIN gene in endothelial cells on NO production and cardiovascular function in vivo using NOSTRIN knockout mice. METHODS AND RESULTS The levels of NO and cGMP were significantly reduced in mice with endothelial cell-specific deletion of the NOSTRIN gene resulting in diastolic heart dysfunction. In addition, systemic blood pressure was increased, and myograph measurements indicated an impaired acetylcholine-induced relaxation of isolated aortic rings and resistance arteries. We found that the muscarinic acetylcholine receptor subtype M3 (M3R) interacted directly with NOSTRIN, and the latter was necessary for correct localization of the M3R at the plasma membrane in murine aorta. In the absence of NOSTRIN, the acetylcholine-induced increase in intracellular Ca(2+) in primary endothelial cells was abolished. Moreover, the activating phosphorylation and Golgi translocation of endothelial NO synthase in response to the M3R agonist carbachol were diminished. CONCLUSIONS NOSTRIN is crucial for the localization and function of the M3R and NO production. The loss of NOSTRIN in mice leads to endothelial dysfunction, increased blood pressure, and diastolic heart failure.
The International Registry of Acute Aortic Dissection (IRAD): new insights into an old disease.

CONTEXT Acute aortic dissection is a life-threatening medical emergency associated with high rates of morbidity and mortality. Data are limited regarding the effect of recent imaging and therapeutic advances on patient care and outcomes in this setting. OBJECTIVE To assess the presentation, management, and outcomes of acute aortic dissection. DESIGN Case series with patients enrolled between January 1996 and December 1998. Data were collected at presentation and by physician review of hospital records. SETTING The International Registry of Acute Aortic Dissection, consisting of 12 international referral centers. PARTICIPANTS A total of 464 patients (mean age, 63 years; 65.3% male), 62.3% of whom had type A dissection. MAIN OUTCOME MEASURES Presenting history, physical findings, management, and mortality, as assessed by history and physician review of hospital records. RESULTS While sudden onset of severe sharp pain was the single most common presenting complaint, the clinical presentation was diverse. Classic physical findings such as aortic regurgitation and pulse deficit were noted in only 31.6% and 15.1% of patients, respectively, and initial chest radiograph and electrocardiogram were frequently not helpful (no abnormalities were noted in 12.4% and 31.3% of patients, respectively). Computed tomography was the initial imaging modality used in 61.1%. Overall in-hospital mortality was 27.4%. Mortality of patients with type A dissection managed surgically was 26%; among those not receiving surgery (typically because of advanced age and comorbidity), mortality was 58%. Mortality of patients with type B dissection treated medically was 10.7%. Surgery was performed in 20% of patients with type B dissection; mortality in this group was 31.4%. CONCLUSIONS Acute aortic dissection presents with a wide range of manifestations, and classic findings are often absent. A high clinical index of suspicion is necessary. Despite recent advances, in-hospital mortality rates remain high. Our data support the need for continued improvement in prevention, diagnosis, and management of acute aortic dissection.
Video Games to Reading: Reaching Out to Reluctant Readers

Junior high school teacher Kristie Jolley believes students become more willing and motivated to practice reading strategies when they are “comfortable within their realm of literacy. ” Background knowledge of video games helps students succeed in understanding and enjoying game-based texts, which she incorporates into her classroom library as encouragement for a habit of reading and as a bridge to increasingly difficult texts. Jolley also offers an overview of popular game-based texts.
Progressive Changes in Inflammatory and Matrix Adherence of Bronchial Epithelial Cells with Persistent Respiratory Syncytial Virus (RSV) Infection (Progressive Changes in RSV Infection)

In addition to the acute manifestations of respiratory syncytial virus (RSV), persistent infection may be associated with long-term complications in the development of chronic respiratory diseases. To understand the mechanisms underlying RSV-induced long-term consequences, we established an in vitro RSV (strain A2) infection model using human bronchial epithelial (16HBE) cells that persists over four generations and analyzed cell inflammation and matrix adherence. Cells infected with RSV at multiplicity of infection (MOI) 0.0067 experienced cytolytic or abortive infections in the second generation (G2) or G3 but mostly survived up to G4. Cell morphology, leukocyte and matrix adherence of the cells did not change in G1 or G2, but subsequently, leukocyte adherence and cytokine/chemokine secretion, partially mediated by intercellular adhesion molecule-1 (ICAM-1), increased drastically, and matrix adherence, partially mediated by E-cadherin, decreased until the cells died. Tumor necrosis factor-α (TNF-α) secretion was inhibited by ICAM-1 antibody in infected-16HBE cells, suggesting that positive feedback between TNF-α secretion and ICAM-1 expression may be significant in exacerbated inflammation. These data demonstrate the susceptibility of 16HBE cells to RSV and their capacity to produce long-term progressive RSV infection, which may contribute to inflammation mobilization and epithelial shedding.
Fronthaul-constrained cloud radio access networks: insights and challenges

As a promising paradigm for fifth generation wireless communication systems, cloud radio access networks (C-RANs) have been shown to reduce both capital and operating expenditures, as well as to provide high spectral efficiency (SE) and energy efficiency (EE). The fronthaul in such networks, defined as the transmission link between the baseband unit and the remote radio head, requires a high capacity, but is often constrained. This article comprehensively surveys recent advances in fronthaul-constrained CRANs, including system architectures and key techniques. Particularly, major issues relating to the impact of the constrained fronthaul on SE/EE and quality of service for users, including compression and quantization, large-scale coordinated processing and clustering, and resource allocation optimization, are discussed together with corresponding potential solutions. Open issues in terms of software-defined networking, network function virtualization, and partial centralization are also identified.
LES in complex geometries using boundary body forces

A numerical method is presented which can simulate flows in complex geometries with moving boundaries while still retaining all the advantages and the efficiency of solving the Navier-Stokes equations on cylindrical grids. The boundary conditions are applied independently of the grid by assigning body forces over surfaces that need not coincide with coordinate lines. The method has been validated by a large-eddy simulation of the flow in a motored axisymmetric piston-cylinder assembly for which experimental measurements are available. The comparison of the results has shown a very good agreement for mean and rms velocity profiles, thus confirming the accuracy of the present approach. This numerical method, in addition, runs on a small PC-like workstation ten times faster than corresponding simulations on supercomputers. In large-eddy simulations the dynamic subgrid-scale model is very efficient in combination with the body force procedure because it automatically accounts for the walls without requiring ad hoc damping functions. This feature is very useful in the present approach since the body surface in general does not coincide with a coordinate line and the computation of the wall distance is time consuming.
An automatic and efficient method of snore events detection from sleep audio recordings

: snores are respiratory sounds produced during sleep. they are reported to be a risk factor for various sleep disorders, such as obstructive sleep apnea syndrome (osa). diagnosis of osa relies on the expertise of the clinician that inspects whole night polysomnographic recording. this inspection is time consuming and uncomfortable for the patients. thus, there is a strong need for a tool to analyze snore sounds automatically. nocturnal respiratory sounds are composed of two kind of events: “silence” episodes and “sound” episodes that include breathing, snoring and “other” sounds. in this paper a new method to detect snoring episodes from full night audio recordings is proposed. signal analysis is performed in three steps: pre-processing, automatic segmentation, extraction of features and classification. With the segmentation step, only the “sound” parts of the audi o signal are extracted using a short-term energy and the otsu thresholding method. the aim of classification step is the detection of snore episodes only, using two neural artificial network applied to four features (length, maximum amplitude, standard deviation and energy). data from 24 subject are analyzed using the proposed method; on the dataset, a sensitivity of 86,2% and specificity of 86,3% are obtained.
Thought Action Fusion in Obsessive Compulsive Disorder

Thought Action Fusion (TAF) is defined as tought and action percieved as equivalent to each other or as an exaggerated power given to idea. With the usage of “Thought Action Fusion Scale” which is created by Shafran (1996), is began to investigate its role in psychopathologies. Researches about the three-component structure which has TAF-Likelihood-Self, TAF-Likelihood-Others, TAF-Moral, are concentrated especially around the obsessive compulsive disorder (OCD). TAF alleged including a certain level also in the normal population, was seen in the relationship with the inflated responsability in OCD, thought suppression and neutralising, was tried to explain the direction of this relationship in the mediationel model framework.
Risk Factors and Outcomes of Methicillin-resistant Staphylococcus Aureus Bacteraemia in Critically Ill Patients: A Case Control Study

Methicillin-resistant Staphylococcus aureus (MRSA) infection is an increasing threat to critically ill patients in many intensive care units. MRSA bacteraemia is an extreme form of MRSA infection and is a significant cause of morbidity and mortality. This case control study aimed to assess the risk factors and outcomes of MRSA bacteraemia compared to methicillin-susceptible Staphylococcus aureus (MSSA) bacteraemia. A total of 21 MRSA bacteraemia and 60 randomly selected MSSA bacteraemia episodes, admitted to the intensive care unit at Royal Perth Hospital between 1997 and 2007, were considered. There was a suggestion that hospitalisation within the preceding six months (P=0.087) and residence in a long-term care facility (P=0.065) were associated with a higher risk of MRSA bacteraemia. MRSA bacteraemia was more often treated with antibiotics to which the pathogen was not susceptible in vitro (38.1% vs 0%, P=0.001), resulting in a longer duration of fever (median 7.0 vs 2.0 days, P=0.009) and bacteraemia (mean 3.2 vs 0.6 days, P=0.005) and a higher incidence of metastatic seeding of infection (52.4% vs 21.7%, P=0.012) as compared to MSSA bacteraemia. While in-hospital mortality between MRSA and MSSA was similarly high (47.6% vs 38.3% for MRSA and MSSA respectively, P=0.607), a significant proportion of the patients who had MRSA bacteraemia died within five years of hospital discharge (36.4%, hazard ratio 26.0, 95% confidence interval 1.90 to 356.7, P=0.015). Infections contributed to 75% of the deaths after hospital discharge in patients who had an episode of MRSA bacteraemia. MRSA bacteraemia carries a much worse long-term prognosis than MSSA bacteraemia and that could be explained by recurrent MRSA infections and residual confounding.
Stability assessment of first order statistics features computed on ADC maps in soft-tissue sarcoma

Radiomics extracts a large number of features from medical images to perform a quantitative characterization. Aim of this study was to assess radiomic features stability and relevance. Apparent diffusion coefficient (ADC) maps were computed from diffusion-weighted magnetic resonance images (DW-MRI) of 18 patients diagnosed with soft-tissue sarcomas (STSs). Thirty-seven intensity-based features were computed on the regions of interest (ROIs). First, ROIs of the images were subjected to translations and rotations in specific ranges. The 37 features computed on the original and transformed ROIs were compared in terms of percentage of variations. The intra-class correlation coefficient (ICC) was computed. To be accepted, a feature should satisfy the following conditions: the ICC after a minimum entity transformation is > 0.6 and the ICC after a maximum entity translation is < 0.4. In total, 31 features out of 37 were accepted by the algorithm. This stability analysis can be used as a first step in the features selection process.
« Changer le système, pas le climat » : la construction du mouvement pour la justice climatique

En decembre 2007, des mouvements sociaux et environnementaux, presents a Bali pour le sommet de l’Onu sur le changement climatique ont decide de creer la coalition « Climate Justice Now ! » (CJN ! ). Deux ans apres, ce reseau a ete l’un des piliers des mobilisations organises en marge du sommet de Copenhague - mobilisations que leurs organisateurs ont decrites comme marquant l’ouverture d’un « nouveau cycle de luttes ». Dans cet entretien, Nicola Bullard? [**] revient pour Mouvements sur la naissance de CJN ! et sur les liens que la coalition entretient avec la dynamique altermondialiste.
Overexpression of TROP2 Predicts Poor Prognosis of Patients with Cervical Cancer and Promotes the Proliferation and Invasion of Cervical Cancer Cells by Regulating ERK Signaling Pathway

Overwhelming evidence has demonstrated that the aberrant expression of the human trophoblast cell-surface antigen (TROP2) was associated with tumor aggressiveness and poor prognosis in a variety of human cancers, however the roles of TROP2 in cervical cancer have not been investigated. The purpose of our study was to elucidate the prognostic significance of TROP2 expression in patients with cervical cancer and determine its effect on tumor progression. Immunohistochemistry assay showed that 88.7% (94/106 cases) of cervical cancer specimens were positively stained with TROP2, and the overexpression of TROP2 was closely related with FIGO stage, histological grades, lymphatic metastasis, invasive interstitial depth and high expression of Ki-67. Patients with TROP2-positive staining exhibited a significantly decreased overall survival and progression free survival; it was also an independent predictor for prognosis according to multivariate analysis. Moreover, down-regulation of TROP2 mediated by siRNA in Siha and CaSki cells resulted in a strong inhibition of proliferation and invasion, TROP2 abrogation also elevated the apoptotic ratio and caused G1 arrest. Conversely, enforced expression of TROP2 in HeLa and C33A cells remarkably promoted cell growth, migration and invasion. In addition, the tumorigenic function of TROP2 was associated with the increased expressions of cyclin D1, cyclin E, CDK2 and CDK4 but reduced expression of p27 and E-cadherin via the activation of Erk1/2 signaling pathway. Furthermore, the inhibition of TROP2 expression in cervical cancer cell lines enhances sensitivity to cisplatin. The present study suggest that overexpression of TROP2 may play crucial roles in the development and pathogenesis of human cervical cancer, therefore, TROP2 may represent a prospective prognostic indicator and a potential therapeutic target of cervical cancer.
Prognostic value and their clinical implication of 89-gene signature in glioma

Gliomas are the most common and aggressive primary tumors in adults. The current approaches, such as histological classification and molecular genetics, have limitation in prediction of individual therapeutic outcomes due to heterogeneity within the tumor groups. Recent studies have proposed several gene signatures to predict glioma's prognosis. However, most of the gene expression profiling studies have been performed on relatively small number of patients and combined probes from diverse microarray chips. Here, we identified prognostic 89 common genes from diverse microarray chips. The 89-gene signature classified patients into good and bad prognostic groups which differed in the overall survival significantly, reflecting the biological characteristics and heterogeneity. The robustness and accuracy of the gene signature as an independent prognostic factor was validated in three microarray and one RNA-seq data sets independently. By incorporating into histological classification and molecular marker, the 89-gene signature could further stratify patients with 1p/19q co-deletion and IDH1 mutation. Additionally, subset analyses suggested that the 89-gene signature could predict patients who would benefit from adjuvant chemotherapy. Conclusively, we propose that the 89-gene signature would have an independent and accurate prognostic value for clinical use. This study also offers opportunities for novel targeted treatment of individual patients.
Controlling Rigid Formations of Mobile Agents Under Inconsistent Measurements

Despite the great success of using gradient-based controllers to stabilize rigid formations of autonomous agents in the past years, surprising yet intriguing undesirable collective motions have been reported recently, when inconsistent measurements are used in the agents' local controllers. To make the existing gradient control robust against such measurement inconsistency, we exploit local estimators following the well-known internal model principle for robust output regulation control. The new estimator-based gradient control is still distributed in nature, and can be constructed systematically even when the number of agents in a rigid formation grows. We prove rigorously that the proposed control is able to guarantee exponential convergence, and then demonstrate through robotic experiments and computer simulations that the reported inconsistency-induced orbits of collective movements are effectively eliminated.
Adenotonsillectomy and the Development of Overweight

OBJECTIVE. Studies among patients have shown accelerated weight gain after (adeno)tonsillectomy. * Whether (adeno)tonsillectomy is also a risk factor for the development of overweight is unknown. We investigated the association between (adeno)tonsillectomy and the subsequent development of overweight in the general population. METHODS. The study population consisted of 3963 children participating in the Dutch Prevention and Incidence of Asthma and Mite Allergy birth cohort. Data on weight and height, adenoidectomy and tonsillectomy, and covariates (gender, birth weight, maternal education, maternal overweight, maternal smoking during pregnancy, breastfeeding, and smoking in the home) were obtained from annual questionnaires completed by the parents. In addition to the questionnaire data, weight and height were measured by the investigators when the children were 8 years old. RESULTS. (Adeno)tonsillectomy between 0 and 7 years of age was significantly associated with overweight and obesity at age 8. Overweight at the age of 2 years was not associated with increased risk of (adeno)tonsillectomy in later years, indicating that the association between (adeno)tonsillectomy and overweight was not explained by preexisting overweight. Longitudinal data on weight and height in the years before and after surgery suggest that (adeno)tonsillectomy forms a turning point between a period of growth faltering and a period of catch-up growth, which might explain the increased risk to develop overweight after the operation. CONCLUSION. Children who undergo (adeno)tonsillectomy are at increased risk to develop overweight in the years after surgery.
Gas Sensing by Microwave Transduction: Review of Progress and Challenges

Microwave transduction is a novel research field in gas sensing owing to its simplicity, low cost, passive, and non-contact operations that indicate a huge potential in applications for gas sensing. At present, the study of microwave gas sensors is limited to testing the macroscopic performance of materials. Although the permittivity change of materials is the reason for microwave transduction, the knowledge of the fundamental mechanism is an urgent requirement for boosting the development of microwave gas sensors. In this review, we summarized the presented progresses of microwave gas sensors, including the performance of the different materials and propagative structures, as well as their sensitive signal. We have attempted to explain the sensitive mechanism of these materials, discuss the function of the propagative structure, and analyze the sensitive signal extracted from the parameters of electromagnetic waves. Finally, the challenges in the study of sensitive materials and propagative structures used in microwave gas sensors are analyzed. It is clear from the published literatures that microwave transduction provide a new route for gas detection, and it is expected that commercial manifestation will occur. The future research on microwave gas sensors will continue to exploit their sensitive materials and propagative structure for different applications. The understanding of the microscopic polarization interactions with gases will assist in and guide the fabrication of high-performance microwave gas sensors in the future.