Miracle-dz/UniFAR-FTUs huggingface dataset:
Real-Time Optimal Voltage Regulation for Distribution Networks Incorporating High Penetration of PEVs

This paper proposes a vehicle-to-grid reactive power support (V2GQ) strategy for optimal coordinated voltage regulation in distribution networks with high distributed generation (DG) penetration. The proposed algorithm employs plug-in electric vehicles (PEVs), DG, and on-load tap changer (OLTC) to satisfy PEV charging demand and grid voltage requirements with relaxed tap operation, and minimum DG active power curtailment. The voltage regulation problem is formulated as a nonlinear programming and consists of three consecutive stages, in which successive stages apply the outputs of their preceding stages as constraints. The first stage aims to maximize the energy delivered to PEVs to assure PEV owner satisfactions. The second stage maximizes the DG extracted active power. Third stage minimizes the voltage deviation from its nominal value utilizing the available PEV and DG reactive powers. The main implicit objective of the third stage problem is relaxing the OLTC tap operation. In addition, the conventional OLTC control is replaced by a proposed centralized controller that utilizes the output of the third stage to set its tap position. Real-time simulations are developed to demonstrate the effectiveness of the proposed optimal coordinated algorithm on a typical distribution network using OPAL-RT real-time simulator (RTS) in a hardware-in-the-loop (HIL) application.
Calabi – Yau theorem and algebraic dynamics

The aim of this paper is to prove the uniqueness part of the Calabi–Yau theorem for metrized line bundles over non-archimedean analytic spaces, and apply it to endomorphisms with the same polarization and the same set of preperiodic points over a complex projective variety. The proof uses Arakelov theory (cf. [Ar, GS]) and Berkovich’s non-archimedean analytic spaces (cf. [Be]) even though the results on dynamical systems can be purely stated over complex numbers. In the following, we will describe our results and main ideas in details.
Comparison of Inductive and Resistive SFCL

This article presents a comparison of inductive and resistive superconducting fault current limiter built with the same length of high temperature superconducting (HTS) tape. The resistive limiter is constructed as a noninductive bifilar winding. The inductive coreless limiter consists of primary winding and secondary shorted winding. Both limiters are connected parallel to the additional Cu primary winding, which helps to reduce the power dissipated in the HTS windings during and after a fault. It also ensures that in cases of an HTS tape failure, the protected circuit will not be disrupted. The limiters are very fast and the first peak is almost equally limited by both types of limiters.
Phase 2 study of frontline brentuximab vedotin monotherapy in Hodgkin lymphoma patients aged 60 years and older.

Outcomes in older patients with Hodgkin lymphoma (HL) tend to be poor following conventional chemotherapy regimens. Treatment-related toxicity is significant and comorbidities often limit therapeutic options. This phase 2, open-label study evaluated the efficacy and safety of brentuximab vedotin, a CD30-directed antibody-drug conjugate, as frontline therapy in 27 HL patients aged ≥60 years. The objective response rate (ORR) was 92%, with 73% achieving complete remission. All patients achieved stable disease or better, and had decreased tumor volume following treatment. At the time of this analysis, the median duration of objective response for efficacy-evaluable patients (N = 26) was 9.1 months (range, 2.8 to 20.9+ months), median progression-free survival was 10.5 months (range, 2.6+ to 22.3+ months), and median overall survival had not been reached (range, 4.6+ to 24.9+ months). The observed adverse events (AEs) were generally consistent with the known safety profile of brentuximab vedotin. The most common AEs were peripheral sensory neuropathy (78%), fatigue (44%), and nausea (44%), and were ≤ grade 2 for most patients. The incidence of grade 3 peripheral neuropathy events was relatively high (30% overall), particularly among patients with the known risk factors of diabetes and/or hypothyroidism (46% vs 14% for those without). However, these risk factors were not associated with delayed time to resolution/improvement of peripheral neuropathy. Preliminary data showed no substantial age-related changes in brentuximab vedotin pharmacokinetics. Brentuximab vedotin monotherapy may provide a frontline treatment option for older patients who cannot tolerate conventional combination chemotherapy. This trial was registered at www.clinicaltrials. gov as #NCT01716806.
Aging and Osteoarthritis: An Inevitable Encounter?

Osteoarthritis (OA) is a major health burden of our time. Age is the most prominent risk factor for the development and progression of OA. The mechanistic influence of aging on OA has different facets. On a molecular level, matrix proteins such as collagen or proteoglycans are modified, which alters cartilage function. Collagen cross-linking within the bone results in impaired plasticity and increased stiffness. Synovial or fat tissue, menisci but also ligaments and muscles play an important role in the pathogenesis of OA. In the elderly, sarcopenia or other causes of muscle atrophy are frequently encountered, leading to a decreased stability of the joint. Inflammation in form of cellular infiltration of synovial tissue or subchondral bone and expression of inflammatory cytokines is more and more recognized as trigger of OA. It has been demonstrated that joint movement can exhibit anti-inflammatory mechanisms. Therefore physical activity or physiotherapy in the elderly should be encouraged, also in order to increase the muscle mass. A reduced stem cell capacity in the elderly is likely associated with a decrease of repair mechanisms of the musculoskeletal system. New treatment strategies, for example with mesenchymal stem cells (MSC) are investigated, despite clear evidence for their efficacy is lacking.
Power-optimized stiffness and nonlinear position control of an actuator with Variable Torsion Stiffness

Introducing compliant actuation to robotic joints is an approach to ensure safety in closer human-machine interaction. Further, the possibility to adjust stiffness can be beneficial considering energy storage and the power consumption required to track certain trajectories. The subject of this paper is the stiffness and position control of the Variable Torsion Stiffness (VTS) actuator for application in compliant robotic joints. For the realization of a variable rotational stiffness, the active length of a torsional elastic element in serial configuration between drive and link is adjusted in VTS. After the deduction of an extended drive train model, this paper gives an advanced power analysis clarifying power-optimal settings from previous basic models and identifying additional settings that allow for a more versatile operation. Based on these results that can be generalized to other variable elastic actuator concepts, an optimized strategy for setting stiffness is determined considering the whole system dynamics including natural frequencies as well as antiresonance effects. For position control of VTS in a prototypical implementation, a nonlinear position controller is designed by means of feedback linearization. Although the system is modified significantly by changing drive train stiffness, the stiffness adaptation of the controller ensures the required tracking performance.
Disulfiram Attenuates Osteoclast Differentiation In Vitro: A Potential Antiresorptive Agent

Disulfiram (DSF), a cysteine modifying compound, has long been clinically employed for the treatment of alcohol addiction. Mechanistically, DSF acts as a modulator of MAPK and NF-κB pathways signaling pathways. While these pathways are crucial for osteoclast (OC) differentiation, the potential influence of DSF on OC formation and function has not been directly assessed. Here, we explore the pharmacological effects of DSF on OC differentiation, activity and the modulation of osteoclastogenic signaling cascades. We first analyzed cytotoxicity of DSF on bone marrow monocytes isolated from C57BL/6J mice. Upon the establishment of optimal dosage, we conducted osteoclastogenesis and bone resorption assays in the presence or absence of DSF treatment. Luciferase assays in RAW264.7 cells were used to examine the effects of DSF on major transcription factors activation. Western blot, reverse transcription polymerase chain reaction, intracellular acidification and proton influx assays were employed to further dissect the underlying mechanism. DSF treatment dose-dependently inhibited both mouse and human osteoclastogenesis, especially at early stages of differentiation. This inhibition correlated with a decrease in the expression of key osteoclastic marker genes including CtsK, TRAP, DC-STAMP and Atp6v0d2 as well as a reduction in bone resorption in vitro. Suppression of OC differentiation was found to be due, at least in part, to the blockade of several key receptor activators of nuclear factor kappa-B ligand (RANKL)-signaling pathways including ERK, NF-κB and NFATc1. On the other hand, DSF failed to suppress intracellular acidification and proton influx in mouse and human osteoclasts using acridine orange quenching and microsome-based proton transport assays. Our findings indicate that DSF attenuates OC differentiation via the collective suppression of several key RANKL-mediated signaling cascades, thus making it an attractive agent for the treatment of OC-mediated disorders.
Indian Diabetic Risk Score and its utility in steroid induced diabetes.

Vikram V Shanbhogue*, Sudha Vidyasagar**, mohit madken***, muralidhar Varma****, Prashant cK#, Pankaj Seth†, Natraj KS‡ *Assistant Professor, Department of medicine, Kasturba medical college, manipal; **Professor & Unit head, Department of medicine, Kasturba medical college, manipal; ***Postgraduate, Department of medicine, Kasturba medical college, manipal; ****Assistant Professor, Department of medicine, Kasturba medical college, manipal; #Assistant Professor, Department of medicine, Kasturba medical college, manipal; †Assistant Professor, Department of medicine, Kasturba medical college, manipal; ‡Postgraduate, Department of medicine, Kasturba medical college, manipal received: 20.03. 2009; revised: 18.05. 2009; re-revised: 16.07. 2009; Accepted: 17.07. 2009
A 12 b 65 MSample/s CMOS ADC with 82 dB SFDR at 120 MHz

A recent trend in cellular basestation design is to digitize multiple channels with a single ADC, often at the intermediate frequency (IF). This requires an ADC with wide dynamic range, particularly SFDR above 80 dB and SNR better than 70 dB, even when sampling input frequencies above 70 MHz. This 12b, 65MSample/s (MSPS) ADC incorporates a wide-bandwidth, low-distortion input stage coupled with a digitally-calibrated, multibit pipeline architecture optimized for low power consumption.
Cryptographically Secure Information Flow Control on Key-Value Stores

We present Clio, an information flow control (IFC) system that transparently incorporates cryptography to enforce confidentiality and integrity policies on untrusted storage. Clio insulates developers from explicitly manipulating keys and cryptographic primitives by leveraging the policy language of the IFC system to automatically use the appropriate keys and correct cryptographic operations. We prove that Clio is secure with a novel proof technique that is based on a proof style from cryptography together with standard programming languages results. We present a prototype Clio implementation and a case study that demonstrates Clio's practicality.
MANAGEMENT OF RESCUE AND RELIEF OPERATIONS USING WIRELESS MOBILE AD HOC TECHNOLOGY

In this paper, we explore the vital rescue and relief application of wireless mobile ad hoc networks for the emergency situations. The self-organizing and decentralized features of ad hoc networks make them suitable for a wide variety of applications. We propose to study the efficiency of some routing and MAC protocols under the Client-Server architecture. The presence of dynamic and adaptive routing and MAC protocols will enable ad hoc networks to be formed quickly, and then to ensure efficient and reliable communications during the rescue operations. Extensive simulations have been realized to show the impact of both the routing and MAC choice over multiple QoS parameters (delay, throughput, energy, etc.) in small and large scales rescue areas. We conclude the paper by some remarks that may be very useful for government agencies working on the emergency situations to enhance the efficiency of rescue and relief operations using ad hoc networks.
Improving information retrieval system performance by combining different text-mining techniques

WordNet, a hand-made, general-purpose, and machine-readable thesaurus, has been used in information retrieval research by many researchers, but failed to improve the performance of their retrieval system. Thereby in this paper we investigate why the use of WordNet has not been successful. Based on this analysis we propose a method of making WordNet more useful in information retrieval applications by combining it with other knowledge resources. A simple word sense disambiguation is performed to avoid misleading expansion terms. Experiments using several standard information retrieval test collections show that our method results in a significant improvement of information retrieval performance. Failure analysis were done on the cases in which the proposed method fail to improve the retrieval effectiveness. We found that queries containing negative statements and multiple aspects might cause problems in the proposed method and we also investigated the solution to these problems.
Estimating Properties of Constraint Solution using Regression Trees

Formulating computational problems in a constraint satisfaction framework is often very attractive, as it allows a clear, declarative specification of solution properties, and offers the potential to exploit preexisting, general-purpose, highly-optimized constraint satisfaction algorithms. Yet most constraint satisfaction algorithms assume that constraint solutions can be efficiently tabulated, and that variable domains can be specified extensionally, in advance of problem solution. In many practical applications these assumptions cannot be met, necessitating the manual specification of an applicationspecific search strategy for constraint satisfaction. In this paper, I explore the use of regression tree learning to estimate the number of solutions a constraint will have, and the cost of finding them, from shallow constraint and variable assignment features. Reliable estimates of these factors may enable the use of principled cost-sensitive search techniques, with less manual intervention, alleviating much of the burden of exploiting constraint satisfaction for practical applications.
Neuropharmacological effect of methylphenidate on attention network in children with attention deficit hyperactivity disorder during oddball paradigms as assessed using functional near-infrared spectroscopy

Abstract. The current study aimed to explore the neural substrate for methylphenidate effects on attentional control in school-aged children with attention deficit hyperactivity disorder (ADHD) using functional near-infrared spectroscopy (fNIRS), which can be applied to young children with ADHD more easily than conventional neuroimaging modalities. Using fNIRS, we monitored the oxy-hemoglobin signal changes of 22 ADHD children (6 to 14 years old) performing an oddball task before and 1.5 h after methylphenidate or placebo administration, in a randomized, double-blind, placebo-controlled, crossover design. Twenty-two age- and gender-matched normal controls without methylphenidate administration were also monitored. In the control subjects, the oddball task recruited the right prefrontal and inferior parietal cortices, and this activation was absent in premedicated ADHD children. The reduced right prefrontal activation was normalized after methylphenidate but not placebo administration in ADHD children. These results are consistent with the neuropharmacological effects of methylphenidate to upregulate the dopamine system in the prefrontal cortex innervating from the ventral tegmentum (mesocortical pathway), but not the noradrenergic system from the parietal cortex to the locus coeruleus. Thus, right prefrontal activation would serve as an objective neurofunctional biomarker to indicate the effectiveness of methylphenidate on ADHD children in attentional control. fNIRS monitoring enhances early clinical diagnosis and the treatment of ADHD children, especially those with an inattention phenotype.
Le rôle de la logistique dans le succès des opérations humanitaires : une approche par les compétences

Au cours des dernieres annees, le nombre de catastrophes naturelles a subi une augmentation effrayante partout dans le monde. Meme si le nombre de deces declares a diminue sur les dernieres annees, le nombre de personnes affectees ne cesse pas d'augmenter, ayant un grand impact dans la facon dont les operations d'aide humanitaire sont developpees. L'aide humanitaire comprend une myriade d'acteurs parmi lesquels on trouve les donateurs, les agences d'aide, les organisations non-gouvernementales (ONG), les gouvernements et les prestataires de service logistique. Dans ce contexte, la logistique represente 80% des activites, et est impliquee dans les trois phases du cycle de la gestion des catastrophes. Dans l'industrie, logistique est considere comme une source d'avantage concurrentiel, expliquant les differences de performance entre les entreprises. Pour le contexte humanitaire, la logistique a la capacite d'assurer le succes des operations, de contribuer a la strategie d'une organisation et permet aux beneficiaires et aux donateurs de distinguer une ONG d'une autre. Cela est possible grâce au developpement des competences et capacites logistiques organisationnelles. L'objectif de cette these est donc d'identifier ces competences et capacites logistiques organisationnelles qui peuvent assurer le succes des operations humanitaires. A travers d'une etude de cas unique effectuee au sein de MSF Logistique, la centrale d'achat et d'approvisionnement de Medecins Sans Frontieres, cette these fournit la preuve du role strategique que la logistique joue dans les activites de l'organisation et propose un modele de competences et capacites logistiques pour le contexte humanitaire.
Parallel Response Selection after Callosotomy

Two studies [Ivry, R. B. , Franz, E. A. , Kingstone, A. , & Johnston, J. C. The psychological refractory period effect following callosotomy: Uncoupling of lateralized response codes. Journal of Experimental Psychology: Human Perception and Performance, 24, 463480, 1998; Pashler, H. , Luck, S. , Hillyard, S. A. , Mangun, G. R. , O'Brien, S. , & Gazzaniga, M. S. Sequential operation of disconnected hemispheres in split-brain patients. NeuroReport, 5, 23812384, 1994] reported robust dual-task costs in split-brain patients even when the two tasks were associated with separate cerebral hemispheres. Although the patients failed to demonstrate specific forms of interference observed in control participants, the timing of the two responses suggested that performance was constrained such that the responses could not be initiated independently. Alternatively, the split-brain participants may have adopted a strategy in which the second response was withheld until the first was initiated. The present study revisits this phenomenon using a procedure in which the stimuli for both tasks are presented simultaneously and neither is given priority over the other. Under these conditions, neurologically intact participants show robust dual-task costs that are mediated by compatibility effects between the responses of the two hands. In contrast, the split-brain participants show greatly reduced dual-task costs and compatibility effects. The minimal dual-task costs observed in the current study indicate that previous dual-task costs in split-brain patients may be strategic, reflecting experimental instructions to prioritize one task, rather than reflect fundamental constraints of the cognitive architecture.
Multilingual Natural Language Generation (Experience from AGILE Project) 1

Multilingual Natural Language Generation is an interesting and challenging field of Natural Language Processing. Automatic generation of texts in natural language could be viewed as a final part of automated translation process from one language to another. Alternative approach is given the chance with development of modern Natural Language Processing technologies, which concentrate the researchers attention on Natural Language Generation as more self-dependent area. Main idea in this respect is the claim that generation of particular text in particular language is a surface realization of particular semantic, which is communicated at the moment in the chosen language. If we have an access to (or description of) that semantic and if we use lexico-grammatical resource, which generates in another natural language we could produce a surface realization of the same semantic in the second natural language. The theoretical base for such a belief is built by functional view to the natural languages. Halliday’s functional analysis of English, Chinese and some other languages is fundamental in this respect. “Introduction to Functional Grammar” describes the basic principles of Systemic Functional Linguistics extracted by analysis of English. Beginning with the most general meta-functions of language (ideational and interpersonal) Systemic Functional Linguistics introduces the idea of communicative functions of language as common for all natural languages. One of the most successful implementations of Hallidey’s theory is the environment KPML, which inherits PENMAN system for Natural Language Generation. KPML gives the researchers basic tools for multilingual sentence generation and resource development. Multilingual generation within KPML starts from common semantics for all languages and traverses the lexico-grammatical resource of each
Flexible modeling of the cumulative effects of time‐dependent exposures on the hazard

Many epidemiological studies assess the effects of time‐dependent exposures, where both the exposure status and its intensity vary over time. One example that attracts public attention concerns pharmacoepidemiological studies of the adverse effects of medications. The analysis of such studies poses challenges for modeling the impact of complex time‐dependent drug exposure, especially given the uncertainty about the way effects cumulate over time and about the etiological relevance of doses taken in different time periods. We present a flexible method for modeling cumulative effects of time‐varying exposures, weighted by recency, represented by time‐dependent covariates in the Cox proportional hazards model. The function that assigns weights to doses taken in the past is estimated using cubic regression splines. We validated the method in simulations and applied it to re‐assess the association between exposure to a psychotropic drug and fall‐related injuries in the elderly. Copyright © 2009 John Wiley & Sons, Ltd.