Miracle-dz/UniFAR-FTUs huggingface dataset:
Experimental Study on Extreme Learning Machine Applications for Speech Enhancement

In wireless telephony and audio data mining applications, it is desirable that noise suppression can be made robust against changing noise conditions and operates in real time (or faster). The learning effectiveness and speed of artificial neural networks are therefore critical factors in applications for speech enhancement tasks. To address these issues, we present an extreme learning machine (ELM) framework, aimed at the effective and fast removal of background noise from a single-channel speech signal, based on a set of randomly chosen hidden units and analytically determined output weights. Because feature learning with shallow ELM may not be effective for natural signals, such as speech, even with a large number of hidden nodes, hierarchical ELM (H-ELM) architectures are deployed by leveraging sparse auto-encoders. In this manner, we not only keep all the advantages of deep models in approximating complicated functions and maintaining strong regression capabilities, but we also overcome the cumbersome and time-consuming features of both greedy layer-wise pre-training and back-propagation (BP)-based fine tuning schemes, which are typically adopted for training deep neural architectures. The proposed ELM framework was evaluated on the Aurora–4 speech database. The Aurora–4 task provides relatively limited training data, and test speech data corrupted with both additive noise and convolutive distortions for matched and mismatched channels and signal-to-noise ratio (SNR) conditions. In addition, the task includes a subset of testing data involving noise types and SNR levels that are not seen in the training data. The experimental results indicate that when the amount of training data is limited, both ELM- and H-ELM-based speech enhancement techniques consistently outperform the conventional BP-based shallow and deep learning algorithms, in terms of standardized objective evaluations, under various testing conditions.
Twitch Mouth Pressure and Disease Severity in Subjects With COPD

INTRODUCTION: Patients with COPD have impaired respiratory muscle strength. Twitch mouth pressure (Ptw,m) in response to magnetic stimulation of the cervical nerve has been suggested to clinically reflect inspiratory muscle strength. However, studies on Ptw,m values and their relationship with disease severity are limited. Thus, we tested the Ptw,m values of subjects with COPD and investigated the relationship of these values with disease severity. METHODS: We recruited 75 COPD patients and 63 age-matched controls. All participants were tested for Ptw,m, sniff nasal pressure (SNIP), and maximum static inspiratory mouth pressure (PImax); the BODE (body mass index, air flow obstruction, dyspnea, exercise capacity) index was evaluated for overall severity assessment and the 6-min walk distance (6MWD) was used to determine the exercise capacity of subjects with COPD. RESULTS: Subjects with COPD had markedly lower Ptw,m values compared with the controls (10.00 ± 2.17 vs 13.66 ± 2.20 cm H2O for males, 8.83 ± 0.89 vs 11.81 ± 1.98 cm H2O for female; each with P < .001). The Ptw,m values decreased with increasing COPD severity, and similar trends were observed in the SNIP and PImax values. Regression correlation analysis showed that Ptw,m values were significantly correlated inversely with the BODE index (R = 0.65, P < .001) but positively correlated with 6MWD (R = 0.59, P < .001) in the COPD group; the SNIP values of subjects with COPD were also correlated inversely with their BODE index (R = 0.49, P < .001) but positively correlated with their 6MWD (R = 0.33, P < .005). CONCLUSIONS: Ptw,m values are 26.8% lower in male subjects with COPD and 25.3% lower in female subjects with COPD compared with the controls. The Ptw,m values of subjects with COPD decrease with increasing disease severity. Ptw,m was better correlated with the BODE index and exercise capacity than SNIP and PImax, which suggests that Ptw,m more accurately reflects the overall severity and burden of COPD.
Role of vasopressin in essential hypertension: Racial differences

Background Arginine vasopressin (AVP), in addition to being an antidiuretic hormone, might also have pressor effects relevant to the maintenance of hypertension. Results from several experimental and clinical studies suggested that the pressor function of AVP is more important in low-renin hypertension and in the salt-loaded state and that it might be further maximized under sympathetic suppression. Objective To assess whether selective vasopressin receptor inhibition lowers the blood pressure in a racially diverse group of low-renin hypertensive subjects. Methods Thirty-nine hypertensive subjects (16 Caucasian, 23 African-American) eating a 200 mmol/day sodium diet were administered a single intravenous dose of a selective vasopressin receptor antagonist and their blood pressure was monitored constantly for the ensuing 3 h. The protocol was repeated 3 days later after treatment with a single oral dose of 0.4 mg clonidine. Results Of these patients, 54% had their blood sampled for determination of hormone profiles. African-Americans with hypertension had higher baseline plasma AVP levels than did Caucasians (1.13 ± 0.05 versus 0.37 ± 0.06 pg/ml, respectively, P < 0.05), and lower plasma renin activity (0.34 ± 0.07 versus 1.03 ± 0.08 ng/ml per h, respectively, P < 0.05). Selective vasopressin receptor inhibition lowered the mean arterial pressure in African-Americans but not that in Caucasians (lowering by 28 ± 4 mmHg in African-Americans versus lowering by 5 ± 3 mmHg in Caucasians, P < 0.05). Moreover, vasopressin receptor blockade further reduced the arterial pressure in African-Americans but not that in Caucasians after pretreatment with clonidine. Conclusion AVP seems to play a more important role as a pressor hormone in maintaining the elevation of arterial pressure in African-American hypertensives than it does in Caucasian hypertensives.
Prognosis of Asymptomatic Patients With Hypertrophic Cardiomyopathy and Nonsustained Ventricular Tachycardia

BackgroundIn the early 1980s, studies performed in highly selected referral patients with hypertrophic cardiomyopathy reported a strong association between the presence of brief episodes of ventricular tachycardia (VT) on ambulatory ECG monitoring and sudden death. These observations led to antiarrhythmic treatment in many patients with hypertrophic cardiomyopathy and brief episodes of VT. In recent years, however, a growing awareness of the potential arrhythmogenic effects of antiarrhythmic medications has raised doubts regarding such a therapeutic approach, particularly in less selected and lower-risk patient populations. Methods and ResultsIn the present study, we examined the prognostic significance of nonsustained VT in a population of 151 patients with hypertrophic cardiomyopathy who were asymptomatic or had only mild symptoms at the time of their initial ambulatory ECG recording. Of the 151 study patients, 42 had episodes of VT and 109 did not. The runs of VT ranged from 3 to 19 beats, with 35 patients (83%) having < 10 beats. The number of runs of VT ranged from 1 to 12 in 24 hours, with 36 patients (86%) having ≤ 5 episodes of VT. Thus, in most patients, the episodes of VT were brief and infrequent. Follow-up averaged 4.8 years. Of the 151 study patients, 6 died suddenly, 3 in the group with VT and 3 in the group without VT. Two other patients, both in the group without VT, died of congestive heart failure. The total cardiac mortality rate was 1.4% per year in the patients with VT (95% CI, 0.4% to 3.5%) and 0.9% in those without VT (95% CI, 0.4% to 2.0%; P = .43). The relative risk of cardiac death for patients with VT was 1.4 compared with patients without VT (95% CI, 0.6 to 6.1). The sudden death rate was 1.4% per year in the patients with VT (95% CI, 0.4% to 3.5%) and 0.6% in those without VT (95% CI, 0.2% to 1.5%; P = .24). The relative risk of sudden death for patients with VT compared with those without VT was 2.4 (95% CI, 0.5 to 11.9). Of the 151 patients included in the study, 88 (58%) remained asymptomatic and were not treated with cardioactive medications during follow-up. Of these 88 patients, 20 were in the group with VT and 68 in the group without VT. None of these patients died. ConclusionsOur results show that cardiac mortality is low in patients with hypertrophic cardiomyopathy who are asymptomatic or only mildly symptomatic and have brief and infrequent episodes of VT on ambulatory ECG monitoring. Our findings also suggest that brief and infrequent episodes of VT should not be considered, per se, an indication for antiarrhythmic treatment in such patients.
Characterization of Vif domains that mediate Feline Immunodeficiency Virus antagonism of APOBEC3-H and APOBEC3-CH restriction

Feline immunodeficiency virus (FIV) Vif mediates degradation of two anti-lentiviral feline APOBEC3 (fA3) proteins, fA3Z3 and fA3Z2bZ3. HIV-1 Vif targets the restriction factor human APOBEC3G (A3G, hA3Z2g-Z1c) for proteasome degradation to mediate viral evasion. Despite this similarity, FIV and HIV-1 Vif share limited homology. Vif binds hA3Z2g-Z1c through its N-terminal region, while its C-terminal region binds to an E3-ligase complex containing Cullin5 and Elongin B/C. Further, HIV-1 Vif contains critical domains in its C-terminus, including an adjacent BC box, the only shared domain between FIV and HIV-1 Vif, and a non-classical zinc finger (HCCH) domain. Felid lentivirus Vif, however, contains a highly conserved KCCC motif. While both Vifs have evolved to counteract select A3 antiretroviral proteins, the FIV Vif domains necessary to target fA3s for degradation are incompletely understood. To identify these domains, we used the well-characterized HIV-1 Vif domains to show that distinct mutations within the BC box of FIV Vif prevent fA3Z3 and fA3Z2bZ3 degradation and reduce virion infectivity. We also found that mutating any single residue in the KCCC motif blocked fA3 targeting and impaired FIV infectivity and replication. These mutations also failed to disrupt the FIV Vif and Cullin5 interaction. Further, we showed that, in contrast to the HCCH domain in HIV-1 Vif, the KCCC domain of FIV Vif does not bind zinc. However, unlike HIV-1 Vif, FIV Vif (C36 isolate) reduces intracellular levels of co-expressed Cullin5 proteins, a novel finding. Our results reveal important C-terminal residues in FIV Vif and show that the BC box and KCCC regions are critical for fA3 degradation, infectivity, and spreading replication.
Application of the TOPSIS Based on Entropy-AHP Weight in Nuclear Power Plant Nuclear-Grade Equipment Supplier Selection

Nuclear power plants (NPPs) has their special characteristics, which both on product safety and on the life cycle of supplier, thus evaluation and selection of the equipment supplier requires independent evaluation index system, based on establishing an evaluation index system, an framework is proposed to address the supplier selection problem in NPP application of improved technique for order preference by similarity to ideal solution (TOPSIS) weighted by analytical hierarchy process (AHP) and entropy value, where it calculates all the indexes’ weights and the distances between the supplier and the ideal solution to find each suppliers’ closeness coefficient. Then the ranking of the suppliers are determined according to their results. Finally, for application and verification, an empirical study is performed to demonstrate the integrated model and identify the suitable supplier(s).
Regulation of cellulase gene expression in the filamentous fungus Trichoderma reesei

Basic features of regulation of expression of the genes encoding the cellulases of the filamentous fungus Trichoderma reesei QM9414, the genes cbh1 and cbh2 encoding cellobiohydrolases and the genes egl1, egl2 and egl5 encoding endoglucanases, were studied at the mRNA level. The cellulase genes were coordinately expressed under all conditions studied, with the steady-state mRNA levels of cbh1 being the highest. Solka floc cellulose and the disaccharide sophorose induced expression to almost the same level. Moderate expression was observed when cellobiose or lactose was used as the carbon source. It was found that glycerol and sorbitol do not promote expression but, unlike glucose, do not inhibit it either, because the addition of 1 to 2 mM sophorose to glycerol or sorbitol cultures provokes high cellulase expression levels. These carbon sources thus provide a useful means to study cellulase regulation without significantly affecting the growth of the fungus. RNA slot blot experiments showed that no expression could be observed on glucose-containing medium and that high glucose levels abolish the inducing effect of sophorose. The results clearly show that distinct and clear-cut mechanisms of induction and glucose repression regulate cellulase expression in an actively growing fungus. However, derepression of cellulase expression occurs without apparent addition of an inducer once glucose has been depleted from the medium. This expression seems not to arise simply from starvation, since the lack of carbon or nitrogen as such is not sufficient to trigger significant expression.
Graphs with no K 3 , 3 Minor Containing a Fixed Edge

It is well known that every cycle of a graph must intersect every cut in an even number of edges. For planar graphs, Ford and Fulkerson proved that, for any edge e, there exists a cycle containing e that intersects every minimal cut containing e in exactly two edges. The main result of this paper generalizes this result to any nonplanar graph G provided G does not have a K 3,3 minor containing the given edge e. Ford and Fulkerson used their result to provide an efficient algorithm for solving the maximum-flow problem on planar graphs. As a corollary to the main result of this paper, it is shown that the Ford-Fulkerson algorithm naturally extends to this more general class of graphs.
Postnatal changes in lymphocyte function of dairy calves.

Lymphocyte blastogenic response, B-lymphocyte population and antibody-producing activity of lymphocytes were determined to evaluate the lymphocyte function in neonatal calves during the first 4 weeks of life. The mean percentage of B-lymphocytes ranged from 10.2 to 12.5% during the first 14 days of life and from 15.3 to 17.5% in calves from the day 21 to day 28 after birth. The absolute number of B-lymphocytes increased significantly (P less than 0.05) from 370/microliters at birth to 736/microliters on day 28 after birth. The mean stimulation index of blastogenic response, measured by fluorometric assay, ranged from 5.75 to 6.61 with Con A, from 5.29 to 5.98 with PHA and from 1.89 to 2.50 with PWM. The mean (+/- S.D.) number of plaque forming cells ranged from 22.0 (+/- 12.0) to 24.7 (+/- 9.2) in cultured lymphocytes from 5 calves at birth to 14 days after birth and their levels increased markedly from 137.8 (+/- 88.3) to 162.0 (+/- 57.8) in lymphocytes from 20 days to 28 days after birth. The present study showed that antibody-producing activity of lymphocytes is lower in calves within 3 weeks after birth compared to that of calves 3 weeks after birth, indicating that neonatal calf lymphocytes have a low antibody-producing activity at least up to 1 month after birth.
Efficient Lifting for Online Probabilistic Inference

Lifting can greatly reduce the cost of inference on first-order probabilistic graphical models, but constructing the lifted network can itself be quite costly. In online applications (e.g., video segmentation) repeatedly constructing the lifted network for each new inference can be extremely wasteful, because the evidence typically changes little from one inference to the next. The same is true in many other problems that require repeated inference, like utility maximization, MAP inference, interactive inference, parameter and structure learning, etc. In this paper, we propose an efficient algorithm for updating the structure of an existing lifted network with incremental changes to the evidence. This allows us to construct the lifted network once for the initial inference problem, and amortize the cost over the subsequent problems. Experiments on video segmentation and viral marketing problems show that the algorithm greatly reduces the cost of inference without affecting the quality of the solutions.
DOMINANT INHERITANCE IN FAMILIAL GENERALISED ARTICULAR HYPERMOBILITY

Hypermobility ofjoints is a feature of many clinical syndromes. It may also exist as a distinct familial disorder. This paper reviews the clinical features and family histories of patients with loose joints and postulates the existence of two separate, genetically determined conditions which are transmitted as autosomal dominant traits and which are characterised by extreme degrees of generalised joint hypermobility.
Joint Loads in Marsupial Ankles Reflect Habitual Bipedalism versus Quadrupedalism

Joint surfaces of limb bones are loaded in compression by reaction forces generated from body weight and musculotendon complexes bridging them. In general, joints of eutherian mammals have regions of high radiodensity subchondral bone that are better at resisting compressive forces than low radiodensity subchondral bone. Identifying similar form-function relationships between subchondral radiodensity distribution and joint load distribution within the marsupial postcranium, in addition to providing a richer understanding of marsupial functional morphology, can serve as a phylogenetic control in evaluating analogous relationships within eutherian mammals. Where commonalities are established across phylogenetic borders, unifying principles in mammalian physiology, morphology, and behavior can be identified. Here, we assess subchondral radiodensity patterns in distal tibiae of several marsupial taxa characterized by different habitual activities (e.g., locomotion). Computed tomography scanning, maximum intensity projection maps, and pixel counting were used to quantify radiodensity in 41 distal tibiae of bipedal (5 species), arboreal quadrupedal (4 species), and terrestrial quadrupedal (5 species) marsupials. Bipeds (Macropus and Wallabia) exhibit more expansive areas of high radiodensity in the distal tibia than arboreal (Dendrolagus, Phascolarctos, and Trichosurus) or terrestrial quadrupeds (Sarcophilus, Thylacinus, Lasiorhinus, and Vombatus), which may reflect the former carrying body weight only through the hind limbs. Arboreal quadrupeds exhibit smallest areas of high radiodensity, though they differ non-significantly from terrestrial quadrupeds. This could indicate slightly more compliant gaits by arboreal quadrupeds compared to terrestrial quadrupeds. The observed radiodensity patterns in marsupial tibiae, though their statistical differences disappear when controlling for phylogeny, corroborate previously documented patterns in primates and xenarthrans, potentially reflecting inferred limb use during habitual activities such as locomotion. Despite the complex nature of factors contributing to joint loads, broad observance of these patterns across joints and across a variety of taxa suggests that subchondral radiodensity can be used as a unifying form-function principle within Mammalia.
Selecting the patients for morning report sessions: case-based vs. conventional method

Background: One of the most important issues in morning report sessions is the number of patients. The aim of this study was to investigate and compare the number of cases reported in the morning report sessions in terms of case-based and conventional methods from the perspective of pediatric residents of Mashhad University of Medical Sciences. Methods: The present study was conducted on 24 pediatric residents of Mashhad University of Medical Sciences in the academic year 2014–2015. In this survey, the residents replied to a 20-question researcher-made questionnaire that had been designed to measure the views of residents regarding the number of patients in the morning report sessions using case-based and conventional methods. The validity of the questionnaire was confirmed by experts’ views and its reliability by calculating Cronbach’s alpha coefficients. Data were analyzed by t-test analysis. Results: The mean age of the residents was 30.852 ± 2.506, and 66.6% of them were female. The results showed that there was no significant relationship among the variables of academic year, gender, and residents’ perspective to choosing the number of patients in the morning report sessions (P > 0.05). T-test analysis showed a significant relationship among the average scores of residents in the selection of the case-based method in comparison to the conventional method (P < 0.001). Conclusion: From the perspective of residents, the case-based morning report was preferred compared to the conventional method. This method makes residents pay more attention to the details of patients’ issues and therefore helps them to better plan how to address patient problems and improve their differential diagnosis skills.
A Natural Gradient Algorithm for Stochastic Distribution Systems

In this paper, we propose a steepest descent algorithm based on the natural gradient to design the controller of an open-loop stochastic distribution control system (SDCS) of multi-input and single output with a stochastic noise. Since the control input vector decides the shape of the output probability density function (PDF), the purpose of the controller design is to select a proper control input vector, so that the output PDF of the SDCS can be as close as possible to the target PDF. In virtue of the statistical characterizations of the SDCS, a new framework based on a statistical manifold is proposed to formulate the control design of the input and output SDCSs. Here, the Kullback–Leibler divergence is presented as a cost function to measure the distance between the output PDF and the target PDF. Therefore, an iterative descent algorithm is provided, and the convergence of the algorithm is discussed, followed by an illustrative example of the effectiveness.
Etymological Wordnet: Tracing The History of Words

Research on the history of words has led to remarkable insights about language and also about the history of human civilization more generally. This paper presents the Etymological Wordnet, the first database that aims at making word origin information available as a large, machine-readable network of words in many languages. The information in this resource is obtained from Wiktionary. Extracting a network of etymological information from Wiktionary requires significant effort, as much of the etymological information is only given in prose. We rely on custom pattern matching techniques and mine a large network with over 500,000 word origin links as well as over 2 million derivational/compositional links.
Combining a backstepping controller with a local stabilizer

We consider nonlinear control systems for which there exist some structural obstacles to the design of classical continuous stabilizing feedback laws. More precisely, it is studied systems for which the backstepping tool for the design of stabilizers can not be applied. On the contrary, it leads to feedback laws such that the origin of the closed-loop system is not globally asymptotically stable, but a suitable attractor (strictly containing the origin) is practically asymptotically stable. Then, a design method is suggested to build a hybrid feedback law combining a backstepping controller with a locally stabilizing controller. The results are illustrated for a nonlinear system which, due to the structure of the system, does not have a priori any globally stabilizing backstepping controller.