Miracle-dz/UniFAR-FTUs huggingface dataset:
Intrusion Detection System Using PSO and DE Algorithms with BP Neural Network

Intrusion detection system (IDS) combines software and hardware to detect network attacks. In this paper, we propose a new intrusion detection method based on an improved BP neural network algorithm. We improve the BP neural network algorithm by combining it with the particle swarm optimization (PSO) algorithm and the differential evolution (DE) algorithm. We also propose a new framework based on common intrusion detection framework to accommodate our improved BP neural network. The experiments based on the CICIDS2017 dataset show our approach achieves better detection efﬁciency.
Combined patterns of activity of major neuronal classes underpin a global change in brain state during spontaneous and forced walk in Drosophila

Movement-correlated brain activity has been found across species and brain regions. Here, we used fast whole-brain lightfield imaging in adult Drosophila to investigate the relationship between walk and neuronal activity. We observed brainwide activity that tightly correlated with spontaneous bouts of walk. While imaging specific sets of excitatory, inhibitory, and neuromodulatory neurons highlighted their joint contribution, spatial heterogeneity in forward walk- and turning-induced activity allowed parsing unique responses from subregions and sometimes individual neurons. For example, previously uncharacterized serotonergic neurons were inhibited during walk. While activity onset in some areas preceded walk onset exclusively in spontaneously walking animals, spontaneous and forced walk elicited highly similar activity in most brain regions. These data suggest a major contribution of walk and walk-related sensory or proprioceptive information to brain state. We conclude that walk-related signals induce global but heterogeneous patterns of activity, allowing for local and brain-wide integration of behavioral state into other processes in the brain.
Scaling of digital shapes with subpixel boundary estimation

Bilevel images consist of a grid of square cells, with side T, which are colored either black or white depending on whether the center of the cell lies in this black or white region of the pre- image. The digitized boundary can be interpreted as a 4-directional chain code. Subpixel accuracy is considered in determining the edge or boundary of the pre-image, and a practical algorithm is given for its implementation. In particular, small curving objects digitized on a coarse grid are considered. Experimental results show a surprisingly high degree of reconstruction, allowing for the upward scaling or enlargement of small objects from their digitized representation.
An adaptive hybrid time‐stepping scheme for highly non‐linear strongly coupled problems

This paper deals with the design and implementation of an adaptive hybrid scheme for the solution of highly non‐linear, strongly coupled problems. The term ‘hybrid’ refers to a composite time stepping scheme where a controller decides whether a monolithic scheme or a fractional step (splitting) scheme is appropriate for a given time step. The criteria are based on accuracy and efficiency. The key contribution of this paper is the development of a framework for incorporating error criteria for stepsize selection and a mechanism for choosing from splitting or monolithic possibilities. The resulting framework is applied to silylation, a highly non‐linear, strongly coupled problem of solvent diffusion and reaction in deforming polymers. Numerical examples show the efficacy of our new hybrid scheme on both two‐ and three‐dimensional silylation simulations in the context of microlithography. Copyright © 2005 John Wiley & Sons, Ltd.
Search for invisible decays at BESIII

Search for physics beyond the standard model is a highly topical in modern particle physics. So far, BESIII experiment has collected the world’s largest data sets at the 𝐽 / 𝜓 and 𝜓 (3686) resonances. The huge data samples and a clean reaction environment provide a ideal place to search for new physics. We report recent searches of the invisible decays 𝐽 / 𝜓 → 𝛾 + invisible and the ﬁrst search for the Λ → invisible in the baryon sector.
RIPARIAN RESERVES SERVE AS A CRITICAL REFUGE FOR ASIAN OTTERS ( Aonyx cinereus and Lutrogale perspicillata ) IN OIL PALM DOMINATED LANDSCAPES OF SABAH, MALAYSIAN BORNEO

: We determined the occupancy of otter species and assessed several habitat features influencing their occurrence in four different land-use types: continuous logged forests (CF), heavily degraded forest (DF), riparian reserves within oil palm plantation (RR), and oil palm plantations without riparian reserves (OP). Our aim was to ascertain the usefulness of retaining riparian reserve in oil palm dominated landscape for otter conservation. This study was conducted in the Malaysian state of Sabah, northern part of Borneo. We surveyed 36 stream sub-transects across all of the different land-use types and detected otter presence based on their tracks and spraints. Overall, two out of the four otter species found in Sabah were detected within the surveyed areas, i.e., the Asian Small-clawed Otter, A. cinereus and Smooth-coated Otter, L. perspicillata . Streams in agricultural sites were found to have significantly higher otter occupancy compared to forested areas: RR ( psi = 0.97), OP (0.83), DF (0.44), and CF (0.37). Using Generalised Linear Modelling (GLM), we identified that otter occupancy in oil palm landscapes was positively influenced by the availability of large trees and other vegetation along the banks. Deeper streams were also more preferred by otters. Interestingly, streams in oil palm plantations located nearer to human settlements recorded higher detection of otter signs. In general, this study suggests that streams in oil palm plantation with riparian vegetation are useful habitat for otter species. Hence, retaining riparian reserves within oil palm plantations is a useful management strategy to improve biodiversity conservation in an agricultural landscape. Citation: Pianzin, A. , Wong, A. and Bernard, H. (2021). Riparian Reserves serve as a Critical Refuge for Asian Otters ( Aonyx cinereus and Lutrogale perspicillata ) in Oil Palm Dominated Landscapes of Sabah, Malaysian Borneo. IUCN Otter Spec. Group Bull . 38 (3): 133 - 154
Different components of air pollutants and neurological disorders

The harmful effects of air pollution can cause various diseases. Most research on the hazards of air pollution focuses on lung and cardiovascular diseases. In contrast, the impact of air pollution on neurological disorders is not widely recognized. Air pollution can cause various neurological conditions and diseases, such as neural inflammation, neurodegeneration, and cerebrovascular barrier disorder; however, the mechanisms underlying the neurological diseases induced by various components of air pollutants remain unclear. The present paper summarizes the effects of different components of air pollutants, including particulate matter, ozone, sulfur oxides, carbon oxides, nitrogen oxides, and heavy metals, on the nervous system and describes the impact of various air pollutants on neurological disorders, providing ideas for follow-up research.
Impedance-based damage assessment of steel-ECC composite deck using piezoelectric transducers

The excellent crack and fatigue resistance of Engineering Cementitious Composites (ECC) materials makes it promising to be used in orthotropic bridge deck system. However, overloading and fatigue load might cause structural damage and, consequently, structural performance degradation. In this work, the piezoelectric lead-zirconate-titanate (PZT) transducers are used to identify the structural damage of the steel-ECC composite deck by implementing both experimental test and numerical simulation. Two steel-ECC composite deck are prepared and four-point bending loading tests are performed on the two specimens to introduce several damage scenarios by gradually increasing the load. The impedance output signals of the piezoelectric sensors are measured under different damage scenarios, and the damage index are extracted to identify the structural damage. A finite element model of the steel-ECC composite deck is established, and the impedance signals with different damage scenarios are calculated and used to assess the structural damages. According to the experimental test and numerical simulation, the impedance-based technology performs to be an effective way to identify the structural damage of the steel-ECC composite deck.
Review of the relationship and underlying mechanisms between the Qinghai–Tibet plateau and host intestinal flora

The intestinal microbial community is the largest ecosystem in the human body, in which the intestinal flora plays a dominant role and has a wide range of biological functions. However, it is vulnerable to a variety of factors, and exposure to extreme environments at high altitudes, as seen on the Qinghai–Tibet plateau, may cause changes in the structure and function of the host intestinal flora. Conversely, the intestinal flora can help the host adapt to the plateau environment through a variety of ways. Herein, we review the relationship and underlying mechanism between the host intestinal flora and the plateau environment by discussing the characteristics of the plateau environment, its influence on the intestinal flora, and the important role of the intestinal flora in host adaptation to the plateau environment. This review aimed to provide a reference for maintaining the health of the plateau population.
Textile electromyography electrodes reveal differences in lower limb muscle activation during loaded squats when comparing fixed and free barbell movement paths

Introduction Traditional recordings of muscle activation often involve time-consuming application of surface electrodes affixed to the skin in laboratory environments. The development of textile electromyography (EMG) electrodes now allows fast and unobtrusive assessment of muscle activation in ecologically valid environments. In this study, textile EMG shorts were used to assess whether performing squats with the barbell resting freely on the shoulders or using a Smith machine for a fixed barbell movement path is preferable for maximizing lower limb muscle activation. Methods Sixteen athletes performed free and fixed barbell squats in a gym with external loads equivalent to their body mass. Quadriceps, hamstrings and gluteus maximus activation was measured bilaterally with textile EMG electrodes embedded in shorts. Results Mean quadriceps activation was greater for the free compared with the fixed movement path for the right (mean difference [MD] 14μV, p = 0.04, ηp2 = 0.28) and left leg (MD 15μV, p = 0.01, ηp2 = 0.39) over the entire squat and specifically during the first half of the eccentric phase for the left leg (MD 7μV, p = 0.04, d = 0.56), second half of the eccentric phase for both legs (right leg MD 21μV, p = 0.05, d = 0.54; left leg MD 23μV, p = 0.04, d = 0.52) and the first half of the concentric phase for both legs (right leg MD 24μV, p = 0.04, d = 0.56; left leg MD 15μV, p = 0.01, d = 0.72). Greater hamstrings activation for the free path was seen for the second half of the eccentric phase (left leg MD 4μV, p = 0.03, d = 0.58) and first half of the concentric phase (right leg MD 5μV, p = 0.02, d = 0.72). No significant differences were found for gluteus maximus. Discussion Textile EMG electrodes embedded in shorts revealed that to maximize thigh muscle activity during loaded squats, a free barbell movement path is preferable to a fixed barbell movement path.
A human-in-the-loop approach for enhancing mobile robot navigation in presence of obstacles not detected by the sensory set

Human-in-the-loop approaches can greatly enhance the human–robot interaction by making the user an active part of the control loop, who can provide a feedback to the robot in order to augment its capabilities. Such feedback becomes even more important in all those situations where safety is of utmost concern, such as in assistive robotics. This study aims to realize a human-in-the-loop approach, where the human can provide a feedback to a specific robot, namely, a smart wheelchair, to augment its artificial sensory set, extending and improving its capabilities to detect and avoid obstacles. The feedback is provided by both a keyboard and a brain–computer interface: with this scope, the work has also included a protocol design phase to elicit and evoke human brain event–related potentials. The whole architecture has been validated within a simulated robotic environment, with electroencephalography signals acquired from different test subjects.
Negotiation-based cooperative planning of local trajectories

In this work, a cooperative local trajectory planner based on negotiation theory for human‐robot interaction is developed. It is implemented on a robot, which accompanies patients to examination rooms as part of the HoLLiECares project. For this purpose, an existing human–machine cooperation model for decision-making in one-time conflict cases is applied to a time-repeated negotiation of motion primitives. In negotiation theory, time pressure in the form of deadlines is classically used to achieve agreements. Since deadlines do not naturally exist in all technical applications and their artificial insertion would create an unintuitive system behavior for an involved human, a reciprocal tit-for-tat strategy for the automation is applied in the present work to achieve agreements. This leads to a system behavior that is able to dynamically change between human-in-the-lead behavior or automation-in-the-lead behavior and everything in between depending on the concession of the human and thus on human’s desire. The cooperative negotiation-based local trajectory planner is tested simulatively.
Systematic review on fiscal policy interventions in nutrition

Introduction Both the World Health Organization and the Lancet Series on Adolescent nutrition recommend that governments adopt fiscal policies to combat diet-related non-communicable diseases (NCDs). However, rigorous, systematic evidence regarding the effects of these interventions is lacking. Methods We synthesize the available evidence regarding the impacts of taxes and subsidies that directly affect consumer prices on availability and accessibility of foods and beverages, purchasing behavior, diet quality, health and well-being outcomes as well as considerations for implementation, sustainability and equity. Results Our initial search returned 2,113 de-duplicated studies, and ultimately 24 impact evaluations and two systematic reviews met final eligibility criteria and represented unique evaluations. Our meta-analysis of these studies suggests that taxes may decrease purchases of taxed beverages (SMD = −0.14 [95% CI: −0.29 to −0.07], n = 15). Results should be interpreted cautiously due to considerable heterogeneity (Q(14) = 335.19, p = 0.01, τ^2=0.03, I2 = 95.82%). Discussion The evidence base is too limited to draw conclusions about the effects of taxes on beverages and calorie-dense foods on purchases, or on the effects of subsidies on purchasing or diet quality. Overall, the evidence base is inconclusive on whether fiscal policies can meaningfully influence the availability and accessibility of foods and beverages, diet quality, and health outcomes. Policymakers implementing fiscal policies should consider information campaigns on health benefits and health risks associated with certain food and beverage consumption. For taxes, exposure to health information may amplify signaling effects of taxes and reduce avoidance behaviors, such as cross-border shopping. Future evaluations should diversify data sources to better understand impacts on diet and health outcomes.
Editorial: Methods and applications in Alzheimer's disease and related dementias

COPYRIGHT © 2022 Yogi and Grosso. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Editorial: Methods and applications in Alzheimer’s disease and related dementias
Visualization of real-time receptor endocytosis in dopamine neurons enabled by NTSR1-Venus knock-in mice

Dopamine (DA) neurons are primarily concentrated in substantia nigra (SN) and ventral tegmental area (VTA). A subset of these neurons expresses the neurotensin receptor NTSR1 and its putative ligand neurotensin (Nts). NTSR1, a G protein-coupled receptor (GPCR), which classically activates Gαq/calcium signaling, is a potential route for modulating DA activity. Drug development efforts have been hampered by the receptor’s complex pharmacology and a lack of understanding about its endogenous location and signaling responses. Therefore, we have generated NTSR1-Venus knock-in (KI) mice to study NTSR1 receptors in their physiological context. In primary hippocampal neurons, we show that these animals express functional receptors that respond to agonists by increasing intracellular calcium release and trafficking to endosomes. Moreover, systemic agonist administration attenuates locomotion in KIs as it does in control animals. Mapping receptor protein expression at regional and cellular levels, located NTSR1-Venus on the soma and dendrites of dopaminergic SN/VTA neurons. Direct monitoring of receptor endocytosis, as a proxy for activation, enabled profiling of NTSR1 agonists in neurons, as well as acute SN/VTA containing brain slices. Taken together, NTSR1-Venus animals express traceable receptors that will improve understanding of NTSR1 and DA activities and more broadly how GPCRs act in vivo.
The dynamics of coordination patterns in multiteam systems response to emergency: Case study from a pharmaceutical enterprise

Effective coordination of multiteam systems (MTSs) can help enterprises respond quickly to complex and uncertain problems under disasters. However, it is unclear how MTS coordination patterns dynamically affect MTS performance in disasters. This study examined how MTSs responded to an emergency production incident at the Zhejiang Huisong Pharmaceutical Company in China during the COVID-19 pandemic through a qualitative and quantitative study. Based on social network theory, we found that a centralized coordination pattern impacts MTS performance by giving play to the leadership team’s network centrality position advantage during the crisis outbreak period. In the post-crisis period, the decentralized coordination pattern impacts MTS performance by giving play to the advantages of horizontal coordination. Our results help managers to consider the dynamics of coordination patterns in crisis management in ways that assist them in adapting an effective coordination pattern to changing and uncertain operational conditions.
The effect of dobutamine on ocular blood flow of healthy adults: A 3D pseudocontinuous aterial spin labelling study

Purpose: Ocular blood flow (OBF) is an important risk factor for incidence, prevalence and progression of some ocular disorders. To date, there are very limited therapeutic options to increase OBF. This study investigated the effect of dobutamine on OBF of heathy adults using 3D pseudocontinuous arterial spin labelling (3D-pcASL), and explored the risk factors associated with OBF. Methods: Forty-three healthy participants (86 eyes) were given an intravenous injection of dobutamine. We measured OBF using 3D-pcASL with a 3.0T- MRI scanner, OBF values were independently obtained by two doctors from the OBF map. We also collected physiological parameters using a vital signs monitor. The OBF and physiological parameters in the in the period before and after dobutamine injection states were obtained. Results: OBF increased significantly after dobutamine injection using paired t test method (from 22.43 ± 9.87 to 47.73 ± 14.02 ml/min/100g, p < 0.001). Age, heart rate and systolic blood pressure were the main risk factors affecting OBF using logistic regression analysis (all p values < 0.05). Conclusion: To the best of our knowledge, this is the first study observing the effect of dobutamine on OBF. Our findings indicated that intravenously injected dobutamine increased OBF, making it a possible option to counteract ocular vascular ischaemia in the future.
Perioperative prothrombin complex concentrate and fibrinogen administration are associated with thrombotic complications after liver transplant

Background Use of intraoperative prothrombin complex concentrates (PCC) and fibrinogen concentrate administration has been linked to thrombotic events. However, it is unknown if its use is associated with thrombotic events after liver transplant. Methods and analysis We conducted a post hoc analysis of a prospectively conducted registry database study on patients who underwent liver transplant between 2004 and 2017 at Heidelberg University Hospital, Heidelberg, Germany. Univariate and multivariate analyses were used to determine the association between PCC and fibrinogen concentrate administration and thrombotic complications. Results Data from 939 transplantations were included in the analysis. Perioperative PCC or fibrinogen administration was independently associated with the primary composite endpoint Hepatic artery thrombosis (HAT), Portal vein thrombosis (PVT), and inferior vena cava thrombosis [adjusted HR: 2.018 (1.174; 3.468), p = 0.011]. PCC or fibrinogen administration was associated with the secondary endpoints 30-day mortality (OR 4.225, p < 0.001), graft failure (OR 3.093, p < 0.001), intraoperative blood loss, red blood cell concentrate, fresh frozen plasma and platelet transfusion, longer hospitalization, and longer length of stay in intensive care units (ICUs) (all p < 0.001). PCC or fibrinogen administration were not associated with pulmonary embolism, myocardial infarction, stroke, or deep vein thrombosis within 30 days after surgery. Conclusion A critical review of established strategies in coagulation management during liver transplantation is warranted. Perioperative caregivers should exercise caution when administering coagulation factor concentrate during liver transplant surgery. Prospective randomized controlled trials are needed to establish causality for the relationship between coagulation factors and thrombotic events in liver transplantation. Further studies should be tailored to identify patient subgroups that will likely benefit from PCC or fibrinogen administration.
Advances of hydrogel combined with stem cells in promoting chronic wound healing

Wounds can be divided into two categories, acute and chronic. Acute wounds heal through the normal wound healing process. However, chronic wounds take longer to heal, leading to inflammation, pain, serious complications, and an economic burden of treatment costs. In addition, diabetes and burns are common causes of chronic wounds that are difficult to treat. The rapid and thorough treatment of chronic wounds, including diabetes wounds and burns, represents a significant unmet medical need. Wound dressings play an essential role in chronic wound treatment. Various biomaterials for wound healing have been developed. Among these, hydrogels are widely used as wound care materials due to their good biocompatibility, moisturizing effect, adhesion, and ductility. Wound healing is a complex process influenced by multiple factors and regulatory mechanisms in which stem cells play an important role. With the deepening of stem cell and regenerative medicine research, chronic wound treatment using stem cells has become an important field in medical research. More importantly, the combination of stem cells and stem cell derivatives with hydrogel is an attractive research topic in hydrogel preparation that offers great potential in chronic wound treatment. This review will illustrate the development and application of advanced stem cell therapy-based hydrogels in chronic wound healing, especially in diabetic wounds and burns.