Miracle-dz/UniFAR-FTUs huggingface dataset:
Recent developments of induction motor drives fault diagnosis using AI techniques

The paper presents a review, of the developments in the field of diagnosis of electrical machines and drives based on artificial intelligence (AI). This review covers the application of expert systems, neural networks and fuzzy logic systems that can be integrated into each other and also with more traditional techniques to overcome specific problems. Usually a diagnostic procedure starts from a fault tree developed on the basis of the physical behaviour of the electrical system under consideration. In this phase the knowledge of well tested models able to simulate the electrical machine in different fault renditions is fundamental to obtain the patterns characterising the faults. Then the fault tree navigation performed by an expert system inference engine leads to the choice of suitable diagnostic indexes, referred to a particular fault, and relevant to build an input dataset for specific AI (neural networks, fuzzy logic or neuro-fuzzy) systems. The discussed methodologies, that play a general role in the diagnostic field, are applied to an induction machine, utilising as input signals the instantaneous voltages and currents. In addition, the supply converter is also considered to also incorporate in the diagnostic procedure the most typical failures of power electronic components. A brief description of the various techniques is provided, to highlight the advantages and the validity limits of using AI technologies. Some application examples are discussed and areas for future research are also indicated.
Interferon‐free treatment of chronic hepatitis C with faldaprevir, deleobuvir and ribavirin: SOUND‐C3, a Phase 2b study

The safety and efficacy of the interferon‐free combination of faldaprevir (NS3/A4 protease inhibitor), deleobuvir (BI 207127, non‐nucleoside polymerase inhibitor), and ribavirin in treatment‐naïve patients chronically infected with HCV genotype‐1 was explored.
SOLUPLUS® FOR MODIFYING THE RELEASE OF HIGHLY WATER SOLUBLE APIs

Well established techniques for increasing the solubility of poorly water soluble APIs are available. However, formulating highly water soluble APIs into dosage forms exhibiting modified release profile is gaining interest. In this work a new application for Soluplus®, a graft copolymer, is launched. A novel approach where Soluplus® is used as a dissolution modifying agent for highly water soluble APIs is introduced. Acetaminophen (APAP) and guaifenesin (GF) were used as model water soluble APIs. 95:5 and 90:10 ratios of respective API and Soluplus® were either physically mixed (PM) together or melted together on a hot plate. Melts were investigated using DSC and XRPD and compacts were submitted to dissolution studies. In case of APAP:Soluplus® a single melting event with an onset similar to pure APAP was determined by DSC. The XRPD diffractogram of molten material exhibited an amorphous halo, however further processing caused the material to crystallize. The compacts made of ground molten materials had a similar release profile and showed a slower release compared to compacts prepared from PMs. When GF:Soluplus® melts were submitted to DSC a single melting event occurred. The onset of this event did not match with the melting event of pure GF. The XRPD diffractogram of the molten samples revealed that a new polymorphic form of GF had crystallized. GF:Soluplus® compacts made of molten material revealed faster release of GF compared to compacts made of PMs of GF:Soluplus®. Using Soluplus® as a dissolution modifying agent enables tailoring of the release of the API. In this work the release of two highly water soluble APIs was modified by two different methods. Furthermore, presence of a new polymorphic form of GF was identified.
A Middleware Approach for IEEE 802.15.4 Wireless Sensor Networks Security

Recent years have seen the growth of interest for middleware (MW) approaches in resource-constrained systems like Wireless Sensor Networks (WSNs). In this context, available MW platforms usually provide an Application Layer with different basic services, but do not provide security services such as secure links management or intrusion detection. Nevertheless, since WSN applications normally require the collection of reliable data from the sensing units, secure communications should be guaranteed even in the presence of resource constraints. So, this paper present a novel MW approach directly tailored to an IEEE 802.15. 4-based WSN. The security-related components of the proposed MW include a light yet powerful cryptographic scheme (TAKS) and an Intrusion Detection System (WIDS). According to the performance and overhead assessment, we may argue that the proposed architecture has potentials to be exploited in realistic application scenarios that rely on the IEEE 802.15. 4.
Diabetic somatic neuropathies.

ropathic pain (7–10), and this and other putative mechanisms will be discussed. The clinical features, diagnosis, and management of the focal and multifocal neuropathies will be described. A major portion of this review will discuss the clinical features, assessment, and management of the patient with the most common form of DN, diabetic distal sensory polyneuropathy (DPN). The late sequelae of DPN and their prevention will also be described. Finally, practical guidelines for the screening of DPN in clinical practice will be provided. For further details on this topic, please refer to recent reviews (11– 18).
Effect of a Proposed Trastuzumab Biosimilar Compared With Trastuzumab on Overall Response Rate in Patients With ERBB2 (HER2)–Positive Metastatic Breast Cancer: A Randomized Clinical Trial

Importance Treatment with the anti-ERBB2 humanized monoclonal antibody trastuzumab and chemotherapy significantly improves outcome in patients with ERBB2 (HER2)–positive metastatic breast cancer; a clinically effective biosimilar may help increase access to this therapy. Objective To compare the overall response rate and assess the safety of a proposed trastuzumab biosimilar plus a taxane or trastuzumab plus a taxane in patients without prior treatment for ERBB2-positive metastatic breast cancer. Design, Setting, and Participants Multicenter, double-blind, randomized, parallel-group, phase 3 equivalence study in patients with metastatic breast cancer. From December 2012 to August 2015, 500 patients were randomized 1:1 to receive a proposed biosimilar or trastuzumab plus a taxane. Chemotherapy was administered for at least 24 weeks followed by antibody alone until unacceptable toxic effects or disease progression occurred. Interventions Proposed biosimilar (n = 230) or trastuzumab (n = 228) with a taxane. Main Outcomes and Measures The primary outcome was week 24 overall response rate (ORR) defined as complete or partial response. Equivalence boundaries were 0.81 to 1.24 with a 90% CI for ORR ratio (proposed biosimilar/trastuzumab) and −15% to 15% with a 95% CI for ORR difference. Secondary outcome measures included time to tumor progression, progression-free and overall survival at week 48, and adverse events. Results Among 500 women randomized, the intention-to-treat population included 458 women (mean [SD] age, 53.6 [11.11] years) and the safety population included 493 women. The ORR was 69.6% (95% CI, 63.62%-75.51%) for the proposed biosimilar vs 64.0% (95% CI, 57.81%-70.26%) for trastuzumab. The ORR ratio (1.09; 90% CI, 0.974-1.211) and ORR difference (5.53; 95% CI, −3.08 to 14.04) were within the equivalence boundaries. At week 48, there was no statistically significant difference with the proposed biosimilar vs trastuzumab for time to tumor progression (41.3% vs 43.0%; −1.7%; 95% CI, −11.1% to 6.9%), progression-free survival (44.3% vs 44.7%; −0.4%; 95% CI, −9.4% to 8.7%), or overall survival (89.1% vs 85.1%; 4.0%; 95% CI, −2.1% to 10.3%). In the proposed biosimilar and trastuzumab groups, 239 (98.6%) and 233 (94.7%) had at least 1 adverse event, the most common including neutropenia (57.5% vs 53.3%), peripheral neuropathy (23.1% vs 24.8%), and diarrhea (20.6% vs 20.7%). Conclusions and Relevance Among women with ERBB2-positive metastatic breast cancer receiving taxanes, the use of a proposed trastuzumab biosimilar compared with trastuzumab resulted in an equivalent overall response rate at 24 weeks. Further study is needed to assess safety and long-term clinical outcome. Trial Registration clinicaltrials.gov Identifier: NCT02472964; EudraCT Identifier: 2011-001965-42
SUSTAINABLE STRENGTH IMPROVEMENT OF SOFT CLAY STABILIZED WITH TWO SIZES OF RECYCLED ADDITIVE

High amounts of ceramic waste is accumulated every year in the disposal and construction sites due to the rejection of all smashed, cracked, and broken tiles. The usage of recycled ceramic crushed tiles (RCT) in improving soft soil is considered an environmentally-friendly, economical and sustainable solution. Soft soils are characterized as problematic soils that are always associated with weak performance when loaded. It is a common practice to excavate, transport and dispose this kind of soil into landfills and replace it with a soil that meets the engineering requirements. Due to shortage of space in landfills and the high costs involved in this processes, soft soils are always treated at construction sites. In this study, two sizes of RCT (0.3 and 1.18 mm) are used to improve the physical and mechanical properties of soft soil. The size and percentage of RCT are investigated and its influence on unconfined compressive strength (UCS) and compaction is evaluated. Microstructural tests included scanning electron microscopic (SEM) and energy dispersive X-ray spectroscopy (EDS) were also conducted on samples treated with RCT. Noticeable increment in both density and unconfined compressive strength was achieved. The maximum dry density increased from 1.59 Mg/m3 to 1.82 Mg/m3 and 1.77 Mg/m3 at the addition of 40 1.18 mm and 0.3 mm RCT, respectively. Whereas the unconfined compressive strength increased from 50 kPa to 250 kPa and 225 kPa at 10 addition of 1.18 mm RCT and 40 0.3 mm RCT, respectively. The optimum value of RCT to treat soft clay was found to be 10 and 40 for 1.18 mm and 0.3 mm RCT, respectively. The remarkable improvement in the strength of soil is due to the development of cementation compounds that acts as a binder between the RCT and soil particles. This study would help in reducing the impacts created by disposing of both problematic soil and waste tiles. Besides, cement is the most traditional material used to stabilize soil. This research would contribute to reducing the CO2 produced during the production of cement. Â© 2018, Int. J. of GEOMATE.
Standardized evaluation of nine instruments for self-monitoring of blood glucose.

BACKGROUND Instruments for self-monitoring of blood glucose (SMBG) should undergo a standardized evaluation including a user-test before being marketed. In this study the results from standardized evaluations of nine different SMBG instruments are presented, and the standardized evaluation is discussed. METHODS Approximately 80 diabetes patients using three lots of test strips participated in each evaluation. Half of the patients were educated in how to use the meter, and the evaluations were carried out by both medical laboratory technologists (MLTs) and patients. Questionnaires were used to assess the user manual and the user-friendliness of the instrument. RESULTS The imprecision obtained by the patients (coefficients of variation [CVs] of 3.2-8.1%) were generally higher compared to that by the MLT (CVs of 2.3-5.9%). Three of the nine instruments did not achieve the quality goal based on the recommendation in the International Organization for Standardization's ISO 15197 guideline in the hands of diabetes patients. The bias from the comparison method ranged from -10.4% to +3.2%. There were significant lot-to-lot variations and hematocrit effects for some of the instruments. Temperature difference between the instruments and the test strip caused deterioration of the quality in one instrument. The user-friendliness was in general acceptable. CONCLUSIONS The quality of instruments for SMBG seems to have improved during recent years, although there are still analytical problems. A standardized evaluation protocol is necessary and should be regularly revised taking into account the development of new technology and the needs of the patients.
Path following for mechanical systems: Experiments and examples

This paper concerns the design of path following controllers for mechanical systems. Our method is to find a coordinate and feedback transformation that puts the mechanical system in a convenient form for path following control design. In this form, linear and controllable subsystems govern motions toward and along the path. We choose a particular "virtual output" to perform input-output feedback linearization, and characterize when this virtual output can be used. We apply this technique to a planar five-bar linkage robot, and implement it experimentally, highlighting behaviour fundamentally different from standard tracking control. In simulation, we further illustrate our approach on an underactuated five-bar robot with a flexible link.
Update to the Management of Pediatric Acute Pancreatitis: Highlighting Areas in Need of Research

ABSTRACT Acute pancreatitis is an emerging problem in pediatrics, with an incidence that is rising in the last 2 decades. Data regarding the optimal management and physician practice patterns are lacking. We present a literature review and updates on the management of pediatric pancreatitis. Prospective multicenter studies defining optimal management of pediatric pancreatitis are needed to guide care and improve outcomes for this patient population.
Framelet based deconvolution

In this paper, two framelet based deconvolution algorithms are proposed. The basic idea of framelet based approach is to convert the deconvolution problem to the problem of inpainting in a frame domain by constructing a framelet system with one of the masks being the given (discrete) convolution kernel via the unitary extension principle of [26], as introduced in [6, 7, 8, 9] . The first algorithm unifies our previous works in high resolution image reconstruction and infra-red chopped and nodded image restoration, and the second one is a combination of our previous frame-based deconvolution algorithm and the iterative thresholding algorithm given by [14, 16]. The strong convergence of the algorithms in infinite dimensional settings is given by employing proximal forward-backward splitting (PFBS) method. Consequently, it unifies iterative algorithms of infinite and finite dimensional setting and simplifies the proof of the convergence of the algorithms of [6].
Targeting Fatigue in Stroke Patients

Symptoms of fatigue are often reported by patients in both the acute and chronic stages of recovery following a stroke. It is commonly associated with low mood and sleep disturbances, but can arise in their absence. However, it has also been associated with poorer long-term outcome and, as such, its aetiology warrants a greater understanding. There is convincing evidence that inflammatory cascades and cytokine signalling precipitated by the infarct promote fatigue, and these pathways may harbour therapeutic targets in its management.
APC/CFZR-1 Controls SAS-5 Levels To Regulate Centrosome Duplication in Caenorhabditis elegans

As the primary microtubule-organizing center, centrosomes play a key role in establishing mitotic bipolar spindles that secure correct transmission of genomic content. For the fidelity of cell division, centrosome number must be strictly controlled by duplicating only once per cell cycle. Proper levels of centrosome proteins are shown to be critical for normal centrosome number and function. Overexpressing core centrosome factors leads to extra centrosomes, while depleting these factors results in centrosome duplication failure. In this regard, protein turnover by the ubiquitin-proteasome system provides a vital mechanism for the regulation of centrosome protein levels. Here, we report that FZR-1, the Caenorhabditis elegans homolog of Cdh1/Hct1/Fzr, a coactivator of the anaphase promoting complex/cyclosome (APC/C), an E3 ubiquitin ligase, functions as a negative regulator of centrosome duplication in the C. elegans embryo. During mitotic cell division in the early embryo, FZR-1 is associated with centrosomes and enriched at nuclei. Loss of fzr-1 function restores centrosome duplication and embryonic viability to the hypomorphic zyg-1(it25) mutant, in part, through elevated levels of SAS-5 at centrosomes. Our data suggest that the APC/CFZR-1 regulates SAS-5 levels by directly recognizing the conserved KEN-box motif, contributing to proper centrosome duplication. Together, our work shows that FZR-1 plays a conserved role in regulating centrosome duplication in C. elegans.
Performance-driven facades: Analysis of natural cross-ventilation in an indoor environment with Fast Fluid Dynamics and apertures optimization based on a genetic algorithm

One of the primary aims of performance-oriented design is to develop spaces that achieve acceptable levels of human comfort. Wind-induced airflow plays a significant role in improving occupants’ comfort in a building. This paper explores the extent to which simulation and evaluation of natural airflow can potentially be a contributing parameter in the conception of performance-aware designs. The authors employed Fast Fluid Dynamics simulation to study the natural ventilation performance of a pavilion and a genetic algorithm to optimize the shape of the pavilion’s facades’ openings. A performance analysis was conducted whereby an array of automated feedback loops carried out by a genetic algorithm produce a number of acceptable solutions. Hence the facade openings of these solutions are considered to be adequate to provide natural ventilation in the indoor environment. The study demonstrates the ability of the optimization model to yield design instances that fulfill a number of environmental criteria related to airflow and human comfort. In this light, the authors suggest that the aforementioned method can be used as an experimentation platform to influence and guide the designer during the initial stages of the design process towards a more performance-driven solution.
Increase in Bone Density in Patients with Spondyloarthritis During Anti-Tumor Necrosis Factor Therapy: 6-year Followup Study

Objective. To assess the effects on bone mineral density (BMD) of prolonged anti-tumor necrosis factor (anti-TNF) therapy in patients with spondyloarthritis (SpA); to compare the BMD changes to those observed in SpA patients not treated with anti-TNF; and to identify the predictors of these changes. Methods. Fifty-nine patients with SpA according to the European Spondylarthropathy Study Group criteria who were treated with anti-TNF therapy for at least 4 years were included. Thirty-four patients with SpA from an international longitudinal observational study (OASIS cohort) were used as a control group. Lumbar spine and hip BMD were measured by dual-energy x-ray absorptiometry at baseline, after 1 year, and after at least 4 years. Results. Over an average 6.5 years’ followup, the increase in BMD was 11.8% (± 12.8%) at the lumbar spine (p < 0.0001) and 3.6% (± 9.3%) at the great trochanter (p = 0.0001) in patients treated with anti-TNF. At the lumbar spine, the increase was similar in patients with and those without syndesmophytes. BMD changes were significantly higher in the anti-TNF group than in the control group at lumbar spine (p < 0.0001), at femoral neck (p = 0.002), and at trochanter (p = 0.011), but not at total hip (p = 0.062). Multivariate analysis showed that the predictors of lumbar spine BMD changes in the total population were the use of anti-TNF (p < 0.0001) and, in the anti-TNF therapy group, the 1-year lumbar spine BMD change (p = 0.007). Conclusion. This study shows that prolonged anti-TNF therapy increases lumbar spine and trochanter BMD. This effect should be taken into account before introducing antiosteoporotic treatment in these patients.
Runtime migration of stateful event detectors with low-latency ordering constraints

Runtime migration has been widely adopted to achieve several tasks such as load balancing, performance optimization, and fault-tolerance. However, existing migration techniques do not work for event detectors in distributed publish/subscribe systems that are used to analyze sensor data. Since low-latency time-constraints are no longer valid they reorder streams incorrectly and cause erroneous event detector states. This paper presents a safe runtime migration of stateful event detectors that respects low-latency time-constraints and seamlessly orders input events correctly on the migrated host. Event streams are only forwarded until timing delays are properly calibrated, the migrated event detector immediately stops processing after its state is transferred, and the processing overhead is negligible. On a Realtime Locating System (RTLS) we show that we can efficiently migrate event detectors at runtime between servers where other techniques would fail.
TLR4 Promotes Cryptosporidium parvum Clearance in a Mouse Model of Biliary Cryptosporidiosis

abstract: Cholangiocytes, the epithelial cells lining intrahepatic bile ducts, express multiple toll-like receptors (TLRs) and, thus, have the capacity to recognize and respond to microbial pathogens. In previous work, we demonstrated that TLR4, which is activated by gram-negative lipopolysaccharide (LPS), is upregulated in cholangiocytes in response to infection with Cryptosporidium parvum in vitro and contributes to nuclear factor-kappaB (NF-kB) activation. Here, using an in vivo model of biliary cryptosporidiosis, we addressed the functional role of TLR4 in C. parvum infection dynamics and hepatobiliary pathophysiology. We observed that C57BL mice clear the infection by 3 wk post-infection (PI). In contrast, parasites were detected in bile and stool in TLR4-deficient mice at 4 wk PI. The liver enzymes alanine transaminase (ALT) and aspartate transaminase (AST), and the proinflammatory cytokines tumor necrosis factor (TNF)-&agr;, interferon (IFN)-&ggr;, and interleukin (IL)-6 peaked at 1 to 2 wk PI and normalized by 4 wk in infected C57BL mice. C57BL mice also demonstrated increased cholangiocyte proliferation (PCNA staining) at 1 wk PI that was resolved by 2 wk PI. In contrast, TLR4-deficient mice showed persistently elevated serum ALT and AST, elevated hepatic IL-6 levels, and histological evidence of hepatocyte necrosis, increased inflammatory cell infiltration, and cholangiocyte proliferation through 4 wk PI. These data suggest that a TLR4-mediated response is required for efficient eradication of biliary C. parvum infection in vivo, and lack of this pattern-recognition receptor contributes to an altered inflammatory response and an increase in hepatobiliary pathology.
Tool health monitoring for wood milling process using airborne acoustic emission

Tool condition monitoring is gaining importance in area of the intelligent manufacturing. It not only reduces the time loss due to breakdown maintenance therefore reduces the production cost. The paper provides an approach to monitor tool health for a wood milling process using airborne acoustic emission. A total of six experiments are conducted for two types of woods; hard wood (Indian rosewood) and soft wood (Kair wood) with different tool health conditions. Acoustic signals of a milling process are recorded through a low-cost microphone and four features have been used for classification. Back-propagation neural network has been used to classify the tool health. Average accuracy of tool condition classification for hard wood is found to be 97.0%, while for the soft wood, it is found to be 78.4%. Experiments shows promising results for tool health monitoring for a wood milling process using airborne acoustic emission.