Miracle-dz/UniFAR-FTUs huggingface dataset:
The relationship between affect balance style and clinical outcomes in fibromyalgia.

OBJECTIVE Affective balance, relative levels of negative affect (NA) and positive affect (PA), better describes emotional functioning than NA or PA alone. Affect balance styles and their relationship to clinical outcomes were compared between patients with fibromyalgia (FM) and controls. METHODS FM patients (n = 79) were compared with patients with other medical conditions (controls; n = 92). Patients underwent a physical examination, completed questionnaires, and were screened for clinical disorders such as depression, with diagnoses confirmed by structured interview. Affect balance style categories were calculated as follows: healthy (high PA/low NA), low (low PA/low NA), reactive (high PA/high NA), and depressive (low PA/high NA). RESULTS Compared with controls, FM patients had lower levels of PA (P = 0.0031; P values are adjusted for multiple testing), higher levels of NA (P = 0.0061), lower levels of functioning (P < 0.0001), and more clinical disorders (P = 0.0031). Groups differed regarding affect balance style (P = 0.0061), with FM patients being more likely than controls to be categorized as depressive (odds ratio 5.60) and reactive (odds ratio 3.81). FM patients and controls with reactive and depressive affect balance styles reported poorer functioning (P < 0.0001) compared with patients with healthy affect balance style. Finally, there was an association between affect balance style and psychiatric comorbidity (P < 0.0001), with patients with depressive and reactive affect balance styles having a 9.00 and 4.75 odds ratio, respectively, of having psychiatric comorbidity compared with patients with healthy affect balance style. CONCLUSION Depressive (low PA, high NA) and reactive (high PA, high NA) affect balance styles were predominant in FM patients and related to poor functioning and psychiatric comorbidity.
Bulgarian tsunami on 7 May 2007: numerical investigation of the hypothesis of a submarine-landslide origin

Abstract We investigate the ability of a submarine landslide to generate the tsunami waves observed on the Bulgarian coast of Black Sea on 7 May 2007. In our simulations, a landslide is presented as a quasi-deformable body moving along a curvilinear slope under action of the forces of gravity, buoyancy, water resistance and bottom friction. We employ the fully non-linear weakly dispersive model for tsunami wave simulations. The computations show that the initial landslide position on the real slope is extremely important for its dynamics and the wave generation process. We constructed some model landslides which generated similar waves to those observed. Moreover, these landslides stopped in the same region. Finally, we evaluated the significance of the frequency dispersion effects in the simulations.
Optimized Integration of Test Compression and Sharing for SOC Testing

The increasing test data volume needed to test core-based system-on-chip contributes to long test application times (TAT) and huge automatic test equipment (ATE) memory requirements. TAT and ATE memory requirement can be reduced by test architecture design, test scheduling, sharing the same tests among several cores, and test data compression. We propose, in contrast to previous work that addresses one or few of the problems, an integrated framework with heuristics for sharing and compression and a constraint logic programming technique for architecture design and test scheduling that minimizes the TAT without violating a given ATE memory constraint. The significance of our approach is demonstrated by experiments with ITC '02 benchmark designs
LPS-Induced Implantation Failure: One of the Causes of Female Infertility

A fundamental feature of implantation is synchronized development of the embryo to the blastocyst stage and differentiation of the uterus to the receptive state. Lipopolysaccharide (LPS), a bacterial endotoxin, is a component of the outer membrane of Gram-negative bacteria and its detection in biologic fluids is an evidence of microbial invasion of a sterile compartment, such as the amniotic cavity. A gramnegative bacterial infection model has been established in the mice. LPS alters the expression of tumor necrosis factor-a, interleukin-1, and colony-stimulating factor. LPS treatment disturbs serum P 4 , E 2 and their receptors. Expression of Hsp90, Hsp70, Hsp60, and Hsp25 also altered due to LPS treatment. LPS disturbs the level of FSH and LH and, FSHR in embryos and ovaries, LHR in embryos and uterus. Disturbance in the embryonic and uterine expression of cytokines, growth factors, steroid hormones and its receptors, gonadotropins and its receptors and heat shock proteins in response to LPS probably trigger the multiple factors in the embryonic and uterine cells, which are responsible for implantation failure. The present review will contribute to our understanding of the mechanism of early pregnancy loss during gram-negative bacterial infection in pregnant mother.
Arp2/3 Branched Actin Network Mediates Filopodia-Like Bundles Formation In Vitro

During cellular migration, regulated actin assembly takes place at the cell leading edge, with continuous disassembly deeper in the cell interior. Actin polymerization at the plasma membrane results in the extension of cellular protrusions in the form of lamellipodia and filopodia. To understand how cells regulate the transformation of lamellipodia into filopodia, and to determine the major factors that control their transition, we studied actin self-assembly in the presence of Arp2/3 complex, WASp-VCA and fascin, the major proteins participating in the assembly of lamellipodia and filopodia. We show that in the early stages of actin polymerization fascin is passive while Arp2/3 mediates the formation of dense and highly branched aster-like networks of actin. Once filaments in the periphery of an aster get long enough, fascin becomes active, linking the filaments into bundles which emanate radially from the aster's surface, resulting in the formation of star-like structures. We show that the number of bundles nucleated per star, as well as their thickness and length, is controlled by the initial concentration of Arp2/3 complex ([Arp2/3]). Specifically, we tested several values of [Arp2/3] and found that for given initial concentrations of actin and fascin, the number of bundles per star, as well as their length and thickness are larger when [Arp2/3] is lower. Our experimental findings can be interpreted and explained using a theoretical scheme which combines Kinetic Monte Carlo simulations for aster growth, with a simple mechanistic model for bundles' formation and growth. According to this model, bundles emerge from the aster's (sparsely branched) surface layer. Bundles begin to form when the bending energy associated with bringing two filaments into contact is compensated by the energetic gain resulting from their fascin linking energy. As time evolves the initially thin and short bundles elongate, thus reducing their bending energy and allowing them to further associate and create thicker bundles, until all actin monomers are consumed. This process is essentially irreversible on the time scale of actin polymerization. Two structural parameters, L, which is proportional to the length of filament tips at the aster periphery and b, the spacing between their origins, dictate the onset of bundling; both depending on [Arp2/3]. Cells may use a similar mechanism to regulate filopodia formation along the cell leading edge. Such a mechanism may allow cells to have control over the localization of filopodia by recruiting specific proteins that regulate filaments length (e.g., Dia2) to specific sites along lamellipodia.
A Hilbert warping method for camera-based finger-writing recognition

We propose a time-warping algorithm for recognizing finger actions by a camera. In the proposed method, an input image sequence is aligned to the reference sequences by phase-synchronization of the analytic signals, and then classified by comparing the cumulative distances. A major benefit of this method is that over-fitting to sequences of incorrect categories is restricted. The proposed method exhibited high recognition accuracy in finger-writing character recognition.
Urbanization on Cyprus: The View from Idalion

Some recent scholarship holds that most societies on Cyprus were agrarian and rural until the Late Bronze Age. Their evidence derives from coastal sites or northern settlements. Evidence has emerged that urbanization began at least in the Middle Bronze Age: a slow process of settlement agglomeration in inland Cyprus. Exploitation of copper and the beginnings of international trade led to a steady growth of settlements, trade, and industry. Inland settlements show rich growth before ca. 2000 B.C.E. A consideration of theories of urbanization and the latest evidence from excavations on Cyprus suggest a rejection of the “urban revolution” or ‘exclusively north-of-the-island’ approaches. Inland sites and re-examinations of older material indicate long, slow growth for the Bronze Age urbanization of the island. A dearth of excavated material from interior urban sites from the Middle and transition to the Late Bronze Ages suggests that a near-term focus on excavations in this period in the interior of the island will clarify just when the settlements became urban centers: probably c.2000 B.C.E. (Figure 1).
Madagascar revisited: A missing data problem

The Madagascar satellite data set provides images of a spreading ridge o the coast of Madagascar. This data set has two regions: the southern half is densely sampled and the northern half is sparsely sampled. The sparsely sampled region presents a missing data problem. I am using prediction-error lters estimated on the dense southern half to ll data on the sparse half. The prediction-error lters eectiv ely spread the texture of the spreading ridge to the sparse tracks.
Mechanism of CYP2C9 Inhibition by Flavones and Flavonols

This article describes an in vitro investigation of the inhibition of cytochrome P450 (P450) 2C9 by a series of flavonoids made up of flavones (flavone, 6-hydroxyflavone, 7-hydroxyflavone, chrysin, baicalein, apigenin, luteolin, scutellarein, and wogonin) and flavonols (galangin, fisetin, kaempferol, morin, and quercetin). With the exception of flavone, all flavonoids were shown to inhibit CYP2C9-mediated diclofenac 4′-hydroxylation in the CYP2C9 RECO system, with Ki value ≤2.2 μM. In terms of the mechanism of inhibition, 6-hydroxyflavone was found to be a noncompetitive inhibitor of CYP2C9, whereas the other flavonoids were competitive inhibitors. Computer docking simulation and constructed mutants substituted at residue 100 of CYP2C9.1 indicate that the noncompetitive binding site of 6-hydroxyflavone lies beside Phe100, similar to the reported allosteric binding site of warfarin. The other flavonoids exert competitive inhibition through interaction with the substrate binding site of CYP2C9 accessed by flurbiprofen. These results suggest flavonoids can participate in interactions with drugs that act as substrates for CYP2C9 and provide a possible molecular basis for understanding cooperativity in human P450-mediated drug-drug interactions.
Phosphorylation of Synaptic Vesicle Protein 2A at Thr84 by Casein Kinase 1 Family Kinases Controls the Specific Retrieval of Synaptotagmin-1

Synaptic vesicle protein 2A (SV2A) is a ubiquitous component of synaptic vesicles (SVs). It has roles in both SV trafficking and neurotransmitter release. We demonstrate that Casein kinase 1 family members, including isoforms of Tau–tubulin protein kinases (TTBK1 and TTBK2), phosphorylate human SV2A at two constellations of residues, namely Cluster-1 (Ser42, Ser45, and Ser47) and Cluster-2 (Ser80, Ser81, and Thr84). These residues are also phosphorylated in vivo, and the phosphorylation of Thr84 within Cluster-2 is essential for triggering binding to the C2B domain of human synaptotagmin-1. We show by crystallographic and other analyses that the phosphorylated Thr84 residue binds to a pocket formed by three conserved Lys residues (Lys314, Lys326, and Lys328) on the surface of the synaptotagmin-1 C2B domain. Finally, we observed dysfunctional synaptotagmin-1 retrieval during SV endocytosis by ablating its phospho-dependent interaction with SV2A, knockdown of SV2A, or rescue with a phosphorylation-null Thr84 SV2A mutant in primary cultures of mouse neurons. This study reveals fundamental details of how phosphorylation of Thr84 on SV2A controls its interaction with synaptotagmin-1 and implicates SV2A as a phospho-dependent chaperone required for the specific retrieval of synaptotagmin-1 during SV endocytosis.
Saccadic Adaptation in 10–41 Month-Old Children

When saccade amplitude becomes systematically inaccurate, adaptation mechanisms gradually decrease or increase it until accurate saccade targeting is recovered. Adaptive shortening and adaptive lengthening of saccade amplitude rely on separate mechanisms in adults. When these adaptation mechanisms emerge during development is poorly known except that adaptive shortening processes are functional in children above 8 years of age. Yet, saccades in infants are consistently inaccurate (hypometric) as if adaptation mechanisms were not fully functional in early childhood. Here, we tested reactive saccade adaptation in 10–41 month-old children compared to a group of 20–30 year-old adults. A visual target representing a cartoon character appeared at successive and unpredictable locations 10° apart on a computer screen. During the eye movement toward the target, it systematically stepped in the direction opposite to the saccade to induce an adaptive shortening of saccade amplitude (Experiment 1). In Experiment 2, the target stepped in the same direction as the ongoing saccade to induce an adaptive lengthening of saccade amplitude. In both backward and forward adaptation experiments, saccade adaptation was compared to a control condition where there was no intrasaccadic target step. Analysis of baseline performance revealed both longer saccade reaction times and hypometric saccades in children compared to adults. In both experiments, children on average showed gradual changes in saccade amplitude consistent with the systematic intrasaccadic target steps. Moreover, the amount of amplitude change was similar between children and adults for both backward and forward adaptation. Finally, adaptation abilities in our child group were not related to age. Overall the results suggest that the neural mechanisms underlying reactive saccade adaptation are in place early during development.
Web-based automatic network discovery/Map Systems

This paper introduces a new automatic network discovery/map system via Web architecture, the so-called Web-based Automatic Network discovery/Map Systems (WANMS). The system functions as a plug-in for a wellknown network management system, Cacti. Enriched features, especially the automatic networking discovery and map module, have been added in order to enhance the efficiency of Cacti embedded with a weather map plug-in. With user defined-pattern functions, the discovery process recognizes a proper type of networking devices. The discovery process generates XML-based information so that a graph visualization using jQuery via HTML5 can generate a simplified network map using a force-directed layout technique. WANMS is easy-to-use and less complicated, and so lessening the discovery time. In particular, for performance comparison with OpenMMS and DNMA, WANMS outperforms others in several perspectives, i.e., faster convergence, better coverage, and more details of types of networking devices. The system is presently used at the department of Information Technology, Provincial Police Region 4, Thailand.
Agile & Kanban In Coordination

Iterative development and Kanban are not mutually exclusive competing methodologies; in essence they are complementary processes that when used together can facilitate higher performance in large development teams. This paper is a walkthrough of the Network Gaming team's implementation of Iterative Agile alongside Lean Kanban here at WMS Gaming. The intent is to cover the processes created and the improvements achieved with this coordinated Agile / Lean system.
Study of the Scale Effect on Permeability in the Interlayer Shear Weakness Zone Using Sequential Indicator Simulation and Sequential Gaussian Simulation

The interlayer shear weakness zone (ISWZ) is a deformation zone in stratified rock masses, with different width and spacing, due to tectonic stresses. It represents the main flow path in rocks due to higher permeability compared with massive rocks. The permeability values of an ISWZ can vary significantly depending on the scale. This study focuses on the correlations between the permeability properties of ISWZs and their geometry properties. A range of realistic 3-D numerical models of ISWZs is developed using geostatistical modeling, with fine-scale geometry and permeability information taken into consideration. These ISWZs represent a set of mud content and width distributions that are typical for ISWZs. Horizontal and vertical permeability values for all ISWZs are found to change in small-scale samples, whereas these fluctuations decrease with increasing sample size. For different types of ISWZs, the results show that ISWZs with variable width will show a significantly larger scale effect on the permeability than that of ISWZs with constant width. Furthermore, ISWZs with a higher mud content display greater variation in horizontal permeability, while the opposite is true for vertical permeability. Based on the coefficient of permeability variation, a criterion is proposed to identify the calculated permeability of a sample is locally homogeneous. The size for this sample relies on the properties estimated (horizontal and vertical permeability) and geometry features. These findings could provide a basis for the selection of permeability values of an ISWZ in hydraulic engineering. Additionally, the procedures used in this article can be applied to any type of ISWZs.
Normobaric hyperoxia alleviates complement C3‐mediated synaptic pruning and brain injury after intracerebral hemorrhage

Abstract Background Intracerebral hemorrhage (ICH) is a common cerebrovascular disease, and the complement cascade exacerbates brain injury after ICH. As the most abundant component of the complement system, complement component 3 (C3) plays essential roles in all three complement pathways. However, the effects of C3 on neurological impairment and brain injury in ICH patients and the related mechanism have not been fully elucidated. Normobaric hyperoxia (NBO) is regarded as a treatment for ICH patients, and recent clinical studies also have confirmed the neuroprotective role of NBO against acute ICH‐mediated brain damage, but the underlying mechanism still remains elusive. Aims In the present study, we investigated the effects of complement C3 on NBO‐treated ICH patients and model mice, and the underlying mechanism of NBO therapy in ICH‐mediated brain injury. Results Hemorrhagic injury resulted in the high plasma C3 levels in ICH patients, and the plasma C3 levels were closely related to hemorrhagic severity and clinical outcomes after ICH. BO treatment alleviated neurologic impairments and rescued the hemorrhagic‐induced increase in plasma C3 levels in ICH patients and model mice. Moreover, the results indicated that NBO exerted its protective effects of on brain injury after ICH by downregulating the expression of C3 in microglia and alleviating microglia‐mediated synaptic pruning. Conclusions Our results revealed that NBO exerts its neuroprotective effects by reducing C3‐mediated synaptic pruning, which suggested that NBO therapy could be used for the clinical treatment of ICH.
Morphofunctional Alteration of Mesenteric Lymph Nodes in the Inflammation of the Abdominal Cavity

Simple Summary Given the important role played by the lymphatic system in tissue drainage, metabolism, water–salt metabolism, and its protective compensatory and immune functions, it is important to further study the role of the lymphatic system in the development of abdominal inflammation. The features of lymph transport through vessels and nodes, the state of formation and biochemical composition of the lymph, the state of innervation of lymph vessels and nodes, and the state of the cellular composition of lymph nodes in the experimental modeling of inflammation in the abdominal cavities of internal organs reveal new insights regarding the mechanisms of this disease. Since, in the literature, only isolated studies regarding the lymphatic system in violation of the abdominal cavity exist, it is clear that the roles and functional states of lymphatic vessels and nodes in inflammation in the abdominal cavity have not yet been studied in a complex and multi-faceted way. Abstract This paper provides data regarding the ratios of the functional structures of lymph nodes after inflammation in the abdominal organs. Lymph systems, including lymph nodes, function as filters of tissues and tissue fluids and are places of origin and lymphocyte production for normal physiological functions. They display specific morphological and functional responses in reaction to endogenous and exogenous substances. The morphological pattern of the mesenteric lymph node in experimental rat groups reflects a decrease in its immune function due to the processes of inflammation in the abdominal cavity. These processes work together with the associated organs and their involvement in the abdominal lymph nodes, in which there are discharges of the structure of the paracortical zone under conditions of reduced lymphogenic processes, according to the decrease in the size of the paracortex and the ratios of lymphoid nodes with and without germinal centers. Histological and morphometric analyses show changes in the mesenteric lymph node. These analyses are characterized by changes in the cortical and medullary substances, while the proportion of the cortical structure decreases. We also noted an increase in the number of macrophages in the lymphoid nodes and cerebral sinus, as well as a decrease in the number of mature plasmocytes, the paracortex, and the pulp strands. These changes indicate immunosuppressive effects on the lymph node. Under the conditions of inflammation, the formation of a mixed immune response occurs.