Miracle-dz/UniFAR-FTUs huggingface dataset:
[Effect of pushing manipulation on Qiaogong acupoint on hemodynamics in cynomolgus monkeys with mild carotid atherosclerotic plaques].

OBJECTIVE To explore the hemodynamic changes in cynomolgus monkeys with mild carotid atherosclerotic (CAS) plaques after therapy with pushing manipulation on Qiaogong acupoint (MPQ). METHODS Nine cynomolgus monkeys were equally randomized into MPQ group, mild CAS model group and blank control group. Mild CAS models were established in the monkeys in MPQ and model groups, and the monkeys in MPQ group received treatment with MPQ intervention after the modeling. The conditions of the carotid artery and the hemodynamic changes in the 3 groups were evaluated after the treatment. RESULTS Formation of CAS plaques was detected in monkeys in both MPQ and model groups. The vascular cross? sectional area, plaque cross? sectional area and stenosis rate of the plaques in the two groups all differed significantly from those in the blank control group (P<0.05), but these parameters were similar between MPQ group and the model group (P>0.05). Compared with those in the blank control group, the hemodynamic parameters showed significant changes in MPQ and the model groups (P<0.05) but remained similar between the latter two groups (P>0.05). CONCLUSION CAS plaques can cause changes in hemodynamic parameters. Short? term therapy with MPQ does not affect the stability of the plaques or cause adverse effects on hemodynamics in cynomolgus monkeys with mild CAS plaques.
Candidate egg case silk genes for the spider Argiope argentata from differential gene expression analyses

Orb‐web weaving spiders produce a variety of task‐specific silks from specialized silk glands. The genetics underlying the synthesis of specific silk types are largely unknown, and transcriptome analysis could be a powerful approach for identifying candidate genes. However, de novo assembly and expression profiling of silk glands with RNA‐sequencing (RNAseq) are problematic because the few known gene transcripts for silk proteins are extremely long and highly repetitive. To identify candidate genes for tubuliform (egg case) silk synthesis by the orb‐weaver Argiope argentata (Araneidae), we estimated transcript abundance using two sequencing methods: RNAseq reads from throughout the length of mRNA molecules, and 3′ digital gene expression reads from the 3′ region of mRNA molecules. Both analyses identified similar sets of genes as differentially expressed when comparing tubuliform and nonsilk gland tissue. However, incompletely assembled silk gene transcripts were identified as differentially expressed because of RNAseq read alignments to highly repetitive regions, confounding interpretation of RNAseq results. Homologues of egg case silk protein (ECP) genes were upregulated in tubuliform glands. This discovery is the first description of ECP homologues in an araneid. We also propose additional candidate genes involved in synthesis of tubuliform or other silk types.
Ultrasonic OFDM Pulse for Beacon Identification and Distance Measurement in Reverberant Environments

In this work we propose a frame architecture for asynchronous data transmission using ultrasonic OFDM pulses in reverberant environments. The frame has two different OFDM pulses modulated with BPSK. The first pulse plays an important role, it is used for time synchronization and to demodulated the unknown data in the second pulse by a differential demodulation scheme. The proposed frame architecture proved to be robust to the multipath in different scenarios. Results have demonstrated that it is possible to keep the bit error rate low in the presence of strong signal echos where other techniques fails, moreover, the simulations show that it would increase the reliability of ultrasonic indoor location systems.
End of life care sedation for children

Purpose of reviewThis article is aimed to review updated research on end-of-life care sedation (EOLC-S) for children and aspects surrounding this issue. Recent findingsPrevalence of EOLC-S for children may vary across countries on account of cultural differences, in terms of settings, legal issues and perceptions about EOLC-S, which lead to variation in patient selection and management. Although home is the preferred place of death for families, research shows hospital settings and ICUs to be the most frequent places where children die. Data on how to define refractory symptoms and update research on drug selection and dosing are lacking. Nature of symptoms at end of life (EOL) is described for cancer patients, but few articles focused on nononcological conditions. Decision making at EOL is commonly discussed with families but children are less frequently involved. SummaryA thorough search of databases was conducted for articles published in the last year. We found few articles describing EOLC-S as a last resort. But how, when and by whom a symptom is defined as refractory, is not well established. Aggressive symptom management at EOL along with advanced care planning conducted by pediatric palliative care teams could diminish EOLC-S. More research is needed.
Lactating adenoma: US features and literature review.

PURPOSE To describe the ultrasonographic (US) features of adenoma in a lactating breast. MATERIALS AND METHODS The US scans of 11 lactating adenomas in nine patients aged 25-36 years examined in 1991-1996 were retrospectively reviewed. In all lesions, diagnoses were cytologically or histologically proved after US-guided fine-needle aspiration biopsy (eight lesions) or core biopsy (three lesions). Six patients were lactating, and three patients were in the third trimester of pregnancy. The US features analyzed were shape, orientation to the chest wall, border characteristics, echogenicity, homogeneity, enhancement or shadowing, and depth within the breast. RESULTS Most lesions had benign US features such as ovoid shape with the long axis parallel to the chest wall (10 of 11), well-defined margins (eight of 11), homogeneous echotexture (eight of 11), and posterior acoustic enhancement (10 of 11). Four lesions had US features that resembled malignant lesions, such as irregular margins, heterogeneous echotexture, and posterior acoustic shadowing. CONCLUSION The US features, although generally benign, are not specific. Tissue sampling with fine-needle aspiration biopsy is recommended. Core biopsy is necessary if a diagnosis cannot be made with the aspirate but is not performed initially because of the possibility of milk fistula formation.
Iron deficiency anemia and anemia of chronic disease in geriatric hospitalized patients: How frequent are comorbidities as an additional explanation for the anemia?

Anemia is an important clinical problem in older patients. The aim of the present study was to investigate whether comorbidities as an additional explanation for the severity of the anemia are frequent, and might help to explain the anemia severity in older patients with iron deficiency anemia (IDA) and the anemia of chronic disease (ACD).
Optimization of calyculin A‐induced premature chromosome condensation assay for chromosome aberration studies

Calyculin A‐induced premature chromosome condensation (PCC) assay is a simple and useful method to assess structural and numerical chromosome aberrations in cells. Our hypothesis in this study is that suboptimum calyculin A induction of PCC resulting in fuzzy compactness and/or shortened length chromosomes would decrease the detection sensitivity of numerical and structural chromosome aberrations such as small PCC rings and small excess fragments. In this study, an optimization of calyculin A exposure on chromosome morphology and PCC induction frequency was investigated using a human peripheral blood lymphocyte (PBL) ex vivo irradiation (60Co‐γ rays; ∼0.6 Gy/min; 0–30 Gy) model. Treatment with calyculin A (50 nM) for 15 and 30 min resulted in 11.3 ± 2.7 and 9.9 ± 1.6‐fold increases in the frequency of G2/M‐PCC cells with extended length chromosomes compared with the 60‐min treated group over a broad dose range (0 to 20 Gy), respectively. The G2/M‐PCC scoring index per PCC in 15‐ and 30‐min treated groups was increased by 1.9 ± 0.2 (P = 0.001) and 1.8 ± 0.2 (P = 0.001) compared with the 60‐min treated group over 0–20 Gy, respectively. The G2/M‐PCC efficiency of 30‐min treated group was highest in the three conditions (i.e., 15‐, 30‐, and 60‐min treatment) of calyculin A exposure. Calyculin A (50 nM) treatment for 30 min before the 48‐h harvest of mitogen‐stimulated human PBL is optimum for the formation of suitable chromosome morphology necessary to assess structural chromosome aberrations induced by exposure to radiation using the chemical induced‐PCC assay. Published 2011 Wiley Periodicals, Inc.
Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression

The glucocorticoid receptor (GR) affects the transcription of genes involved in diverse processes, including energy metabolism and the immune response, through DNA-binding dependent and independent mechanisms. The DNA-binding dependent mechanism occurs by direct binding of GR to glucocorticoid response elements (GREs) at regulatory regions of target genes. The DNA-binding independent mechanism involves binding of GR to transcription factors and coactivators that, in turn, contact DNA. A small molecule that competes with GR for binding to GREs could be expected to affect the DNA-dependent pathway selectively by interfering with the protein-DNA interface. We show that a DNA-binding polyamide that targets the consensus GRE sequence binds the glucocorticoid-induced zipper (GILZ) GRE, inhibits expression of GILZ and several other known GR target genes, and reduces GR occupancy at the GILZ promoter. Genome-wide expression analysis of the effects of this polyamide on a set of glucocorticoid-induced and -repressed genes could help to elucidate the mechanism of GR regulation for these genes.
A method of one-pass seed generation for LFSR-based deterministic/pseudo-random testing of static faults

This paper proposes a method of LFSR seed generation for deterministic and pseudo-random testing of static faults. The proposed method directly generate seeds by using ATPG and avoids unsuccessful encoding of conventional two-pass generation methods. The effectiveness of the proposed method is evaluated through experiments for several LFSRbased pseudo-random pattern generators. The quality of seeds generated by the proposed method is evaluated by stuck-at fault coverage when test patterns are expanded from seeds.
Talent identification and women's soccer: An Australian experience

This study used a quasi-applied research model to identify and develop potentially talented female soccer players. Athletes aged 15–19 years with a background in team ball sports or athletics were targeted for recruitment using advertisements and promotions through various media. Interested athletes attended a 2-day programme of testing, which included assessment of anthropometric, physiological and skill attributes. A combination of factors was used in the final selection of 17 athletes to take part in a 12-month talent development programme. A pre-season programme of five training sessions per week was conducted for 2 months. This programme focused on enabling the players to acquire the necessary ball and game skills to perform competitively in a short time. The squad competed as a team in the reserve grade competition of an Australian state league. At the conclusion of the 25-game season, 10 players were selected for zone teams with two players progressing to state team selection within 6 months. The project demonstrates that it is possible to select potential female soccer players based on anthropometric, physiological and skill attributes.Selection procedures could be enhanced through the development of objective assessment tools that measure tactical and technical competence. Programmes such as this can offer an additional avenue of player recruitment in support of existing procedures.
Multiple view semi-supervised discriminant analysis

Beyond conventional semi-supervised dimensionality reduction methods which data are represented in a single vector or graph space, multiple view semi-supervised ones are to learn a hidden consensus pattern from multiple representations of multiple view data together with some domain knowledge. Under multiple view settings, we propose a new Multiple view Semi-supervised Discriminant Analysis (MSDA). Specifically, the labeled data are used to infer the discriminant structure in each view. Simultaneously, all the data, including the labeled and the unlabeled instances, are used to discover the intrinsic geometrical structure in each view. Thus, we can learn an optimal pattern from the multiple patterns of multiple representations with serial combination after getting the projection of each view. Experiments carried out on real-world data sets by MSDA show a clear improvement over the results of representative dimensionality reduction algorithms.
Mifepristone or inhibition of 11beta-hydroxylase activity potentiates the sedating effects of the cannabinoid receptor-1 agonist Delta(9)-tetrahydrocannabinol in mice.

The cannabinoid system is a regulator of neurotransmission and is linked with hormonal control. We have found in experimental mouse studies that the progesterone receptor inhibitor mifepristone (RU38486, 80 mg/kg i.p.) or the 11beta-hydroxylase inhibitor metyrapone (100 mg/kg i.p.) when administered in combination with cannabinoids potentiates the transient-sedating cannabinoid receptor-1 effects of a high-dose Delta(9)-tetrahydrocannabinol (25 mg/kg i.p.), causing severe prolonged sedation associated with hypomotility, catalepsy and hypothermia. This observation has implications for human subjects taking these drugs and related compounds particularly because of the ubiquitous use of cannabis and the high potential for mifepristone and related compounds to become available on the 'black-market' as abortifacients.
Stepwise transformation of rat embryo fibroblasts: c-Jun, JunB, or JunD can cooperate with Ras for focus formation, but a c-Jun-containing heterodimer is required for immortalization

Among the Jun family of transcription factors, only c-Jun displays full transforming potential in cooperation with activated c-Ha-Ras in primary rat embryo fibroblasts. c-Jun in combination with Ras can both induce foci of transformed cells from rat embryo fibroblast monolayers and promote the establishment of these foci as tumoral cell lines. JunB can also cooperate with Ras to induce foci but is unable to promote immortalization. We report here that JunD, in cooperation with Ras, induces foci with an efficiency similar to that of JunB. Artificial Jun/eb1 derivatives from each of the three Jun proteins were also analyzed. These constructs carry a heterologous homodimerization domain from the viral EB1 transcription factor and are thought to form only homodimers in the cell. We show here that these Jun/eb1 chimeras are potent transactivators of AP1 sites and that they can cooperate with c-Ha-Ras to induce foci. However, among all the Ras-Jun and Ras-Jun/eb1 combinations tested, only foci from Ras-c-Jun can be efficiently expanded and maintained as long-term growing cultures. Therefore, we suggest that a heterodimer containing c-Jun might be required for in vitro establishment of these primary mammalian cells.
Prognostic significance of intratumoural microvessel density (IMD) in resected pancreatic and ampullary cancers to standard histopathological variables and survival.

AIM Angiogenesis is required for tumour growth. Its evaluation, by intratumoural microvessel density (IMD), has prognostic significance in many solid tumours. There is controversy regarding its use in pancreatic cancer and little is known about its role in ampullary tumours. The aim is to study IMD as a prognostic marker in resected ductal adenocarcinomas of head of pancreas and cancers of the ampullary region. METHODS Forty-seven patients (23 pancreatic and 24 ampullary, mean age 62.0 years) surviving a potentially curative (R0/R1) resection were analysed. Paraffin-embedded sections of these tumours were immunohistochemically stained for CD-34 and IMD was determined (magnification x200). This was correlated with histopathological data and survival using Cox's multivariate analysis. RESULTS Mean survival for the pancreatic cancer group was 18.4 months (SE=2.7) and 81.2 months (SE=9.9) for the ampullary cancer group. In the pancreatic cancer group, IMD was found to have independent prognostic significance to survival on multivariate analysis (P=0.002, Hazard Ratio (HR) 13.60) along with microscopic resection margin involvement (P=0.003, HR 15.18). For ampullary cancers, IMD was higher in those with lymph node metastasis (P=0.02, Mann-Whitney U -test). CONCLUSION IMD in resected pancreatic cancers correlates with survival.
Impaired Autophagy in Neurons after Disinhibition of Mammalian Target of Rapamycin and Its Contribution to Epileptogenesis

Certain mutations within the mammalian target of rapamycin (mTOR) pathway, most notably those affecting the tuberous sclerosis complex (TSC), lead to aberrant activation of mTOR and result in a high incidence of epilepsy in humans and animal models. Although hyperactivation of mTOR has been strongly linked to the development of epilepsy and, conversely, inhibition of mTOR by rapamycin treatment is protective against seizures in several models, the downstream epileptic mechanisms have remained elusive. Autophagy, a catabolic process that plays a vital role in cellular homeostasis by mediating the turnover of cytoplasmic constituents, is negatively regulated by mTOR. Here we demonstrate that autophagy is suppressed in brain tissues of forebrain-specific conditional TSC1 and phosphatase and tensin homlog knock-out mice, both of which display aberrant mTOR activation and seizures. In addition, we also discovered that autophagy is suppressed in the brains of human TSC patients. Moreover, conditional deletion of Atg7, an essential regulator of autophagy, in mouse forebrain neurons is sufficient to promote development of spontaneous seizures. Thus, our study suggests that impaired autophagy contributes to epileptogenesis, which may be of interest as a potential therapeutic target for epilepsy treatment and/or prevention.
Wavelet based fast fractal image compression

Image compression is a significant technology in the transmission and storage of digital images. The importance of image compression is that to preserve the visual feature of the image. One of the finest image compression techniques is using wavelet transform which have comparatively had several benefits over other. Basically wavelets are confined in both time and frequency. Wavelet transformations perform multilevel decomposition of image that is diving image into sub parts of image at different measures. Discrete wavelet transform examined the signal at a different frequency bandwidth that is approximate band and detail band. Using wavelet with balance resolution at any time and frequency gives a better signal illustration using multilevel analysis. Therefore, at very low bit rate the suggested method improves the visual feature of decoded image.
Rho-kinase inhibitor, fasudil, suppresses glioblastoma cell line progression in vitro and in vivo

There is growing evidence that the Rho/Rho-kinase (ROCK) signaling pathway is upregulated in tumors and plays a key role in cancer invasion and proliferation. The aim of this study was to explore the anti-tumor effects of Rho/ROCK inhibitor, fasudil, including the possible mechanisms involved in the suppression of the glioblastoma (GBM) cell line progression in vitro and in vivo. After T98G and U251 cells were treated with various concentrations of fasudil, Y27632, and ROCK siRNA, the effects of ROCK inhibitors on migration, invasion, invasion-related gene expressions, proliferation, and apoptosis of cultured tumor cells were examined. The results indicated that fasudil significantly inhibited not only proliferation, migration, and invasiveness (P < 0.05) but also the mRNA and protein expressions of matrix metalloproteinase-2 (MMP-2) in a dose-dependent manner. Moreover, fasudil treatment resulted in a dose-dependent increase of apoptosis in T98G and U251. The intracranial xenograft models were established. The cryosection of the tumor and the survival time of mice in each group indicated that fasudil could inhibit glioma invasion and growth in vivo. Based on the results, fasudil suppresses the progression of GBM in vitro and in vivo by inhibiting ROCK. This could be linked to the decreased MMP-2 expression and the induction of apoptosis in tumor cells. The Rho/ROCK signaling pathway may prove to be a promising target in anti-tumor therapy. Fasudil may be an attractive anti-tumor drug candidate for the treatment of GBM.
Oil Price Shocks and Stock Markets in ASEAN-5

This paper examines the impact of oil price shocks and oil price volatility on real stock prices in Indonesia, Malaysia, Philippines, Singapore and Thailand. Using a monthly structural vector autoregression model estimated separately for each country from 1997:7 to 2013:12, the results show that in response to an oil price shock, real stock prices fall within six months in all the countries as the central banks increase interest rates to reduce inflationary pressures. In contrast to the findings in existing studies on the US and European countries, monetary policy shocks in ASEAN-5 are more important in explaining the variability in real stock returns compared to oil price shocks. The fall in real stock prices is also observed under both positive and negative oil price shocks, suggesting that oil price volatility plays an important role in explaining stock price movements. In response to an increase in oil price volatility, real stock prices are depressed immediately but they gradually recover as the economic situation improves. JEL Classification: C32, E44
A Low-Power Wideband CMOS LNA for WiMAX

In this brief, the design of a low-power inductorless wideband low-noise amplifier (LNA) for worldwide interoperability for microwave access covering the frequency range from 0.1 to 3.8 GHz using 0.13-mum CMOS is described. The core consumes 1.9 mW from a 1.2-V supply. The chip performance achieves S11 below -10 dB across the entire band and a minimum noise figure of 2.55 dB. The simulated third-order input intercept point is -2.7 dBm. The voltage gain reaches a peak of 11.2 dB in-band with an upper 3-dB frequency of 3.8 GHz, which can be extended to reach 6.2 GHz using shunt inductive peaking. A figure of merit is devised to compare the proposed designs to recently published wideband CMOS LNAs
Paradoxical Hyperplasia Post Cryolipolysis and Management

Currently, a plethora of clinical strategies has been utilized for the noninvasive removal of localized fat deposits, such energy-based devices (cryolipolysis, radiofrequency, low-level laser, ultrasound, and acoustic waves), topicals, and injectable biologics. The efficacy, number of treatments needed, treatment tolerability, and side effects differ among the various approaches, but overall, their safety and efficacy has been validated via multiple peerreviewed clinical studies.