Miracle-dz/UniFAR-FTUs huggingface dataset:
Harmonizing AC and DC: A Hybrid AC/DC Future Grid Solution

It has been over 100 years since Thomas Edison built the first direct current (dc) electricity supply system on 4 September 1882, at Pearl Street in New York City. Many prominent events occurred in the electricity supply industry after that. The first one, ? the war of currents,? started in 1888. Thomas Edison and his dc distribution system were on one side, and George Westinghouse and Nikolai Tesla with the alternating current (ac) system were on other side. The war ? ended? in about 1891 when ac won as the dominant power supply medium. The key behind the ac win was the invention of the transformer that could easily step up medium voltage to high and extra-high voltage for long-distance power transfer from a remote ac generation station to load centers hundreds of kilometers away with lower transmission losses. Transformers can also step down high voltage back to low voltage at load stations to supply the low-voltage equipment. Since the end of the war, ac power systems have been developed and expanded at a tremendous speed from the initial small isolated networks, with each supplying only lighting and motor loads with a few hundreds of customers, to its current scale of super interconnected networks each supplying billions of customers over large geographic areas in one or several countries. The voltage levels and capacities of transmission networks have increased from the first commercialized three-phase ac system with only 2.4 kV, 250 kW in the town of Redlands, California, United States, to the first commercial long-distance, ultra-high-voltage, ac transmission line in China with 1,000 kV, 2,000 MW. Transmission distance has been increased from several miles to over thousands of kilometers (miles). With such major achievements, it is little wonder that the ac power system became the top engineering achievement of the 20th century. Does this mean that dc is gone? The answer is an unambiguous no. What has happened in the past 50 years, such as applications of advanced control technologies in conventional power system loads, the power electronics based high-voltage dc (HVdc) transmission, and the additional renewable power sources in low-voltage distribution system, calls for a rethink about dc and ac in electricity supply systems.
The broadcast century and beyond

Chapter 1 In the Beginning: Genesis to 1920 Chapter 2 The Roaring 20s: Promise, Chaos, and Controls Chapter 3 The Terrible 30s: Profit and Depression Chapter 4 The Furious 40s: War and Recovery--Full of Sound and Fury, Signifying.Transition to TV Chapter 5 The Fearful 50s: Broadcasting and Blacklisting--A Decade of Shame Chapter 6 The Soaring 60s: Awakening, Rebellion, and the Moon Chapter 7 The Shifting 70s: Q and Q and Jiggle Chapter 8 The Techno-Edged 80s: Teflon, Tinsel, and Me Chapter 9 The Cyber 90s: Toward a New Century Chapter 10 The New Century--The 2000s: Webs and Digits Further Reading Index
Analysis of the Frequency Locking Region of Coupled Oscillators Applied to 1-D Antenna Arrays

During the past decade, coupled oscillators have shown their efficiency as simple methods for phase control in microwave antenna arrays, and hence as alternatives to conventional electronic beam steering methods. In this paper, a new writing of the nonlinear equations proposed by R. York to describe the oscillators locked states is presented. This has allowed the elaboration of a CAD tool which provides, in a considerably short simulation time, the frequency locking region of the coupled oscillators. This region is plotted versus the oscillators' tunings referred to the resonant frequency of the coupling circuit. A prototype circuit consisting of a five oscillators array is currently under test to validate the theory.
Multipotential stromal cell abundance in cellular bone allograft: comparison with fresh age-matched iliac crest bone and bone marrow aspirate.

AIM To enumerate and characterize multipotential stromal cells (MSCs) in a cellular bone allograft and compare with fresh age-matched iliac crest bone and bone marrow (BM) aspirate. MATERIALS & METHODS MSC characterization used functional assays, confocal/scanning electron microscopy and whole-genome microarrays. Resident MSCs were enumerated by flow cytometry following enzymatic extraction. RESULTS Allograft material contained live osteocytes and proliferative bone-lining cells defined as MSCs by phenotypic and functional capacities. Without cultivation/expansion, the allograft displayed an 'osteoinductive' molecular signature and the presence of CD45(-)CD271(+)CD73(+)CD90(+)CD105(+) MSCs; with a purity over 100-fold that of iliac crest bone. In comparison with BM, MSC numbers enzymatically released from 1 g of cellular allograft were equivalent to approximately 45 ml of BM aspirate. CONCLUSION Cellular allograft bone represents a unique nonimmune material rich in MSCs and osteocytes. This osteoinductive graft represents an attractive alternative to autograft bone or composite/synthetic grafts in orthopedics and broader regenerative medicine settings.
l-Isoleucine Production with Corynebacterium glutamicum: Further Flux Increase and Limitation of Export

The synthesis of l-isoleucine with Corynebacterium glutamicum involves 11 reaction steps, in at least five of which activity or expression is regulated. We used four genes and alleles encoding feedback-resistant enzymes (Fbr) in various combinations to assay flux increase through the sequence. During strain construction, the order of genes overexpressed was important. Only when ilvA(Fbr) was first overexpressed could hom(Fbr) be introduced. This succession apparently prevents the toxic accumulation of biosynthesis intermediates. The best strain constructed (SM13) was characterized by high-level expression of hom(Fbr), thrB, and ilvA(Fbr). With this strain a yield of 0.22 g of l-isoleucine per g of glucose was obtained, with a maximal specific productivity of 0.10 g of l-isoleucine per g (dry weight) per h. In strain SM13, with the high metabolite flux through the reaction sequence, effects on (i) other enzyme levels, (ii) time-dependent variations with process time, and (iii) concentrations of cytosolic intermediates were quantified. Most importantly, the intracellular l-isoleucine concentration is always higher at all process times than the extracellular concentration. The intracellular concentration rises to 110 mM, whereas extracellularly only 60 mM is accumulated. Also the immediate l-isoleucine precursor 2-ketomethyl valerate accumulates in the cell. Therefore, in the high-level l-isoleucine producer SM13, the export of this amino acid is the major limiting reaction step and therefore is a new target of strain design for biotechnological purposes.
Agent-Based Embedded Monitoring System for Ubiquitous Networks Environments

─ Contrary to current wireless network systems, ubiquitous network environment has quite dynamic and diversified devices which aim at best meeting the requirements of specific group of users for a specific purpose. In order to obtain the seamless transparency within mobile devices, accurate and efficient monitoring of dynamically changing environments is one of the most important requirements for ubiquitous network environments. In this paper, we describe the novel agent-based embedded monitoring systems for wireless network devices. By utilizing the light-weight mobile agent technology, our monitoring system can be a useful tool for ubiquitous network environments. This agent-based approach, moreover, provides seamless transparency. Our proposed monitoring system can automate the installation and updating process of monitoring code. We also implement our agent-based monitoring system on embedded Linux-based wireless ad hoc network testbed. Keywords─ Embedded Systems, Ubiquitous Computing, Mobile Ad Hoc Networks, Resource Monitoring, Networks Managements
Speckle reduction of TerraSAR-X imagery using TV segmentation

The nonsubsampled contourlet transform (NSCT) is a new image representation approach that has sparser representation at both spatial and directional resolution and thus captures smooth contours in images. On the other hand, wavelet transform has sparser representation of homogeneous areas. In this paper, we are going to use the three combinations of undecimated wavelet and nonsubsampled contourlet transforms that was used in for denoising of TerraSAR-X images. Two of the methods use the undecimated wavelet transform to de-noise homogeneous areas and the nonsubsampled contourlet transform to denoise areas with edges. The segmentation between homogeneous areas and areas with edges is done by using total variation segmentation. The third method is a linear averaging of the two denoising methods. A thresholding in the wavelet and contourlet domain is done by non-linear functions which are adapted for each selected subband. The non-linear functions are based on sigmoid functions. Simulation results suggested that these denoising schemes achieve good and clean images.
Automated Assessment of Programming Assignments

This is a position paper in which I argue that massive open online programming courses can benefit by the application of automated assessment of programming assignments. I gathered success factors and identified concerns related to automatic assessment through the analysis of experiences other researchers have reported when designing and using automated assessment of programming assignments and interpret their potential applicability in the context of massive open online courses (MOOCs). In this paper I explain the design of our own assessment software and discuss our experience of using it in relation to the above-mentioned factors and concerns. My reflection on this experience can inform MOOC designers when having to make decisions regarding the use of automatic assessment of programming assignments.
Expression of Cell-Surface Marker ABCB5 Causes Characteristic Modifications of Glucose, Amino Acid and Phospholipid Metabolism in the G3361 Melanoma-Initiating Cell Line

We present a pilot study aimed at determining the effects of expression of ATP-binding cassette member B5 (ABCB5), a previously described marker for melanoma-initiating cells, on cellular metabolism. Metabolic profiles for two groups of human G3361 melanoma cells were compared, i.e. wildtype melanoma cells with intact ABCB5 expression (ABCB5-WT) and corresponding melanoma cell variants with inhibited ABCB5 expression, through shRNA-mediated gene knockdown (ABCB5-KD). A comprehensive metabolomic analysis was performed by using proton and phosphorus NMR spectroscopy of cell extracts to examine water-soluble metabolites and lipids. Parametric and non-parametric statistical analysis of absolute and relative metabolite levels yielded significant differences for compounds involved in glucose, amino acid and phospholipid (PL) metabolism. By contrast, energy metabolism was virtually unaffected by ABCB5 expression. The sum of water-soluble metabolites per total protein was 17% higher in ABCB5-WT vs. ABCB5-KD G3361 variants, but no difference was found for the sum of PLs. Enhanced abundance was particularly pronounced for lactate (+ 23%) and alanine (+ 26%), suggesting an increase in glycolysis and potentially glutaminolysis. Increases in PL degradation products, glycerophosphocholine and glycerophosphoethanolamine (+ 85 and 123%, respectively), and redistributions within the PL pool suggested enhanced membrane PL turnover as a consequence of ABCB5 expression. The possibility of glycolysis modulation by an ABCB5-dependent IL1β-mediated mechanism was supported by functional studies employing monoclonal antibody (mAb)-dependent ABCB5 protein inhibition in wildtype G3361 melanoma cells. Our metabolomic results suggest that the underlying biochemical pathways may offer targets for melanoma therapy, potentially in combination with other treatment forms.
Molecular Characterization of a Prevalent Ribocluster of Methicillin-Sensitive Staphylococcus aureus from Orthopedic Implant Infections. Correspondence with MLST CC30

Staphylococcus aureus is the leading etiologic agent of orthopedic implant infections. Here a ribocluster of 27 S. aureus strains underwent further molecular characterization and subtyping by multilocus sequence typing (MLST) and spa-typing. This cluster had been detected by automated ribotyping (with the EcoRI restriction enzyme) of 200 S. aureus isolates from periprosthetic infections of patients who underwent revision at the Rizzoli Orthopaedic Institute. The ribocluster, consisting of agr type III strains, with a 74% co-occurrence of bone sialoprotein-binding (bbp) and collagen-binding (cna) genes, lacked mecA and IS256, and exhibited a high prevalence of the toxic shock syndrome toxin gene (tst, 85%). Strains' relatedness was analyzed by BURP and eBURST. Two predominant spa types, t012 (32%) and t021 (36%), and one predominant sequence type, ST30 (18/27, 67%) were identified: a S. aureus lineage spread worldwide belonging to MLST CC30. Two new sequence types (ST2954, ST2960) and one new spa type (t13129) were detected for the first time. Interestingly, the 27-strain cluster detected by ribotyping corresponded exactly to MLST CC30, the sole CC identified by eBURST.
Enhanced transepithelial flux of cimetidine by Madin-Darby canine kidney cells overexpressing human P-glycoprotein.

Cimetidine has been used as a relatively selective inhibitor of renal organic cation secretion, analogous to the use of probenecid to inhibit organic anion secretion. Many of the substrates for the multidrug transporter P-glycoprotein, which is overexpressed in multidrug-resistant tumor cells, are organic cations. Furthermore, the protein is normally expressed on the apical membranes of proximal tubule cells, the postulated site for active organic cation secretion. To test directly whether P-glycoprotein might serve as a carrier for cimetidine, we measured cimetidine transepithelial movement across Madin-Darby canine kidney cells grown as monolayers on membrane filters. A retrovirally transduced Madin-Darby canine kidney cell line (Madin-Darby canine kidney cells transfected with the human multiple drug resistance 1 cDNA for P-glycoprotein), that expresses the human form of P-glycoprotein on its apical membrane, had an increased capacity to transport cimetidine from the basolateral to apical medium (b-->a) but not in the reverse direction (i.e., a-->b). Qualitatively similar results were observed with daunomycin, a well established substrate for P-glycoprotein. Cellular uptake and energy-dependent efflux experiments further established cimetidine to be a substrate for the human P-glycoprotein. Thus, P-glycoprotein may play a role in the renal secretion of cimetidine and perhaps other organic cations.
Mothers with Severe Mental Illness Caring for Children

This research identifies and describes the Massachusetts population of Department of Mental Health (DMH) case-managed women with severe mental illness who are caretakers of their minor children (N = 314), and compares their demographic and clinical characteristics and service utilization with those of a matched, randomly selected group of DMH case-managed noncaretaking women (N = 328) using the Client Tracking System database. Caretakers were significantly younger, had less formal education, and had higher rates of marriage than did noncaretakers. They are diagnosed more often with major affective disorders and less often with psychotic disorders. Caretakers demonstrate higher levels of functioning and are less likely to have a representative payee. Although caretakers function better, the groups do not differ significantly in their use of DMH services. This is the first systematic, statewide effort to specify the unique characteristics of this substantial group of women with severe mental illness who are caring for their children.
Collembola as alternative prey sustaining spiders in arable ecosystems: prey detection within predators using molecular markers

Collembola comprise a major source of alternative prey to linyphiid spiders in arable fields, helping to sustain and retain these predators as aphid control agents within the crop. Polymerase chain reaction primers were developed for the amplification, from spider gut samples, of DNA from three of the most abundant species of Collembola in wheat crops in Europe, namely Isotoma anglicana, Lepidocyrtus cyaneus and Entomobrya multifasciata. The primers amplified fragments of the mitochondrial cytochrome oxidase subunit I (COI) gene and were designed following alignment of comparable sequences for a range of predator and prey species. Each of the primer pairs proved to be species‐specific to a Collembola species, amplifying DNA fragments from 211 to 276 base pairs in length. Following consumption of a single collembolan, prey DNA was detectable in 100% of spiders after 24 h of digestion. We report the first use of DNA‐based techniques to detect predation by arthropods on natural populations of prey in the field. All three species of Collembola were consumed by the spiders. By comparing the ratios of the Collembola species in the field with the numbers of spiders that gave positive results for each of those species, it was possible to demonstrate that the spiders were exercising prey choice. Overall, a single target species of Collembola was eaten by 48% of spiders while a further 16% of spiders contained DNA from two different species of Collembola. Preference was particularly evident for I. anglicana, the species most frequently found in spider guts yet the least numerous of the three target species in the field.
Zoomable User Interfaces for the Authoring and Delivery of Slide Presentations

Millions of slide presentations are being authored and delivered with computer software every day. Yet much of the computer's power for these tasks remains untapped. Existing interaction techniques leave presenters wrestling with limited size computer displays to get meaningful overviews of their work. Without these overviews, they have trouble finding patterns in their data and experimenting with alternate organizations. They also have difficulty communicating the structure of large or complex talks to the audience and keeping the audience oriented during unexpected transitions between ideas. A natural solution is Zoomable User Interfaces (ZUIs) since they offer the capability to view information at multiple levels of detail and smoothly transition between ideas. This work presents two ZUIs, Niagara and CounterPoint, for authoring and delivering slide presentations. Niagara is a ZUI workspace for authoring presentation content with techniques to improve authoring in the zoomable environment. Empirical evaluations of ZUI-based authoring tools revealed performance improvements and subjective preferences over folder-based interfaces for organization tasks. Users were 30% faster with ZUIs than with folders in completing a simplified shape organization task. Some classes of users were also faster with ZUIs than with folders in completing a text-based organization task. Users performing both tasks exhibited a strong preference for ZUIs over folders. CounterPoint provides a number of features to simplify the creation and delivery of ZUI presentations. The effects of these presentations on the audience were evaluated in a controlled comparison of presentations with slides only, slides with spatial layouts, and slides with spatial layouts and animation. The study revealed a strong subjective preference and higher ratings of organization for presentations with spatial layout. Feedback was also gathered from presenters who used CounterPoint to deliver over 100 real-world presentations. They indicated that CounterPoint helped them communicate overviews and multi-level presentation structures. More experienced CounterPoint presenters also found that CounterPoint helped them keep the audience oriented when navigating the presentation in response to audience feedback.
Effektiv sikkerhetstesting av webapplikasjoner med rikt innhold

I nyere webapplikasjoner er brukerinnhold, interaktivitet og rask responstid blitt viktig. Kravene medforer nye kommunikasjonsmodeller og applikasjonslogikk pa klientsiden. Utviklingen har fort til .
Optimal Estimation for Networked Control Systems with Intermittent Inputs without Acknowledgement

Abstract This paper investigates the optimal estimation problem for networked control systems, where the control packets are randomly dropped without acknowledgement to the estimator. Most existing results for this setup are concerned with the design of controller, while the optimal estimation and its performance evaluation have not been fully studied. This paper shows, unlike many other cases such as intermittent observations or TCP-like systems, the system state follows a Gaussian mixture distribution with exponentially increasing terms. The optimal estimation is obtained by Gaussian sum filtering, while the computation is time- consuming. By constructing an auxiliary estimator, a fast and stable filtering algorithm is proposed to improve computational efficiency.
Ischemic core and penumbra in human stroke.

BACKGROUND AND PURPOSE The ischemic core and penumbra have not been thoroughly characterized after acute cerebral thromboembolic occlusion in humans. Differentiation between areas of potentially viable and irreversibly injured ischemic tissue may facilitate assessment and treatment of stroke patients. METHODS Cerebral blood flow (CBF) was measured in 20 patients with acute middle cerebral artery (MCA) occlusion between 60 and 360 minutes after stroke onset, with the stable xenon computerized tomography (CT) technique. Threshold displays were generated at a single level, and the percentages of hemisphere with CBF </=6, </=10, 11 to 20, 21 to 30, and >30 cm3. 100 g-1. min-1 were measured. The corresponding images on 12 available follow-up CT scans were similarly assessed to determine the area of final infarct. Comparisons were analyzed with a paired Student's t test and Pearson's correlation coefficient. RESULTS Discrete and confluent areas of CBF </=20 cm3. 100 g-1. min-1 were identified in all patients, ipsilateral to the symptomatic MCA territory. The average area of CBF </=20 cm3. 100 g-1. min-1 within the ipsilateral hemisphere was 66+/-17% compared with 36+/-12% contralaterally (P<0.001). A difference in the extent of low CBF was due primarily to areas with CBF </=10 cm3. 100 g-1. min-1 (48+/-18% versus 16+/-7%, P<0.001). The area of most severe ipsilateral ischemia (</=6 cm3. 100 g-1. min-1) best corresponded to the final area of infarction (37+/-18% versus 40+/-24%; correlation coefficient, 0.866; P<0.01). The acute ischemic core destined to infarction was not surrounded by a widened rim of moderate ischemia because the area with CBF 11 to 20 cm3. 100 g-1. min-1 was similar bilaterally (19+/-4% versus 20+/-7%, P=0.792, thus not significant). CONCLUSIONS Our study in acute human stroke involving MCA occlusion indicates that a severely ischemic core (CBF </=6 cm3. 100 g-1. min-1), observed between 1 to 6 hours after stroke onset, corresponds to the cerebral tissue destined to infarction. The ischemic penumbra with flow values between 7 and 20 cm3. 100 g-1. min-1 surrounding the ischemic core is very narrow. Therefore, strategies to improve the outcome of many patients with acute MCA occlusion must either include interventions to reverse the ischemic process within a few minutes of onset or increase the cerebral tolerance of ischemia and thereby prolong the potential therapeutic window.