Miracle-dz/UniFAR-FTUs huggingface dataset:
Detection and characterization of MuSK antibodies in seronegative myasthenia gravis

Antibodies to rat muscle specific kinase, MuSK, have recently been identified in some generalized “seronegative” myasthenia gravis (SNMG) patients, who are often females with marked bulbar symptoms. Using immunoprecipitation of 125I‐labelled‐human MuSK, 27 of 66 (41%) seronegative patients were positive, but 18 ocular SNMG patients, 105 AChR antibody positive MG patients, and 108 controls were negative. The antibodies are of high affinity (Kds around 100 pM) with titers between 1 and 200 nM. They bind to the extracellular Ig‐like domains of soluble or native MuSK. Surprisingly they are predominantly in the IgG4 subclass. MuSK‐antibody associated MG may be differnet in etiological and pathological mechanisms.
New treatment approach in Indian visceral leishmaniasis: single-dose liposomal amphotericin B followed by short-course oral miltefosine.

BACKGROUND In Bihar, India, home to nearly one-half of the world's burden of visceral leishmaniasis, drug resistance has ended the usefulness of pentavalent antimony, which is the traditional first-line treatment. Although monotherapy with other agents is available, the use of 2 drugs with different modes of action might increase efficacy, shorten treatment duration, enhance compliance, and/or reduce the risk of parasite resistance. To test the feasibility of a new approach to combination therapy in visceral leishmaniasis (also known a kala-azar), we treated Indian patients with a single infusion of liposomal amphotericin B (L-AmB), followed 1 day later by short-course oral miltefosine. METHODS We used a randomized, noncomparative, group-sequential, triangular design and assigned 181 subjects to treatment with 5 mg/kg of L-AmB alone (group A; 45 subjects), 5 mg/kg of L-AmB followed by miltefosine for 10 days (group B; 46 subjects) or 14 days (group C; 45 subjects), or 3.75 mg/kg of L-AmB followed by miltefosine for 14 days (group D; 45 subjects). When it became apparent that all regimens were effective, 45 additional, nonrandomized patients were assigned to receive 5 mg/kg of L-AmB followed by miltefosine for 7 days (group E). RESULTS Each regimen was satisfactorily tolerated, and all 226 subjects showed initial apparent cure responses. Nine months after treatment, final cure rates were similar: group A, 91% (95% confidence interval [CI], 78%-97%]; group B, 98% (95% CI, 87%-100%); group C, 96% (95% CI, 84%-99%]; group D, 96% (95% CI, 84%-99%); and group E, 98% (95% CI, 87%-100%). CONCLUSIONS These results suggest that treatment with single-dose L-AmB followed by 7-14 days of miltefosine is active against Indian kala-azar. This short-course, sequential regimen warrants additional testing in India and in those regions of endemicity where visceral leishmaniasis may be more difficult to treat. TRIAL REGISTRATION ClinicalTrials.gov identifier: NCT00370825 .
Physiological Interactions Of Calcium And Vitamin D In Colon

This study aimed to review the literature about possible physiological interactions of calcium and vitamin D in colon. Previous studies have indicated to protective effects of vitamin D and calcium in case of colon cancers. We wanted to check the physiological effects of both of vitamin D and calcium, and either of each of them alone. We suggested effects of metabolism through induction of changes in the levels of various biomarkers that have influences in carcinogenesis including p53, heat shock proteins, iNOS and WT1 gene.
Metabolic syndrome across Europe: Different clusters of risk factors

Background: Metabolic syndrome (MetS) remains a controversial entity. Specific clusters of MetS components – rather than MetS per se – are associated with accelerated arterial ageing and with cardiovascular (CV) events. To investigate whether the distribution of clusters of MetS components differed cross-culturally, we studied 34,821 subjects from 12 cohorts from 10 European countries and one cohort from the USA in the MARE (Metabolic syndrome and Arteries REsearch) Consortium. Methods: In accordance with the ATP III criteria, MetS was defined as an alteration three or more of the following five components: elevated glucose (G), fasting glucose ≥110 mg/dl; low HDL cholesterol, < 40mg/dl for men or <50 mg/dl for women; high triglycerides (T), ≥150 mg/dl; elevated blood pressure (B), ≥130/≥85 mmHg; abdominal obesity (W), waist circumference >102 cm for men or >88 cm for women. Results: MetS had a 24.3% prevalence (8468 subjects: 23.9% in men vs. 24.6% in women, p < 0.001) with an age-associated increase in its prevalence in all the cohorts. The age-adjusted prevalence of the clusters of MetS components previously associated with greater arterial and CV burden differed across countries (p < 0.0001) and in men and women (p < 0.0001). In details, the cluster TBW was observed in 12% of the subjects with MetS, but was far more common in the cohorts from the UK (32.3%), Sardinia in Italy (19.6%), and Germany (18.5%) and less prevalent in the cohorts from Sweden (1.2%), Spain (2.6%), and the USA (2.5%). The cluster GBW accounted for 12.7% of subjects with MetS with higher occurrence in Southern Europe (Italy, Spain, and Portugal: 31.4, 18.4, and 17.1% respectively) and in Belgium (20.4%), than in Northern Europe (Germany, Sweden, and Lithuania: 7.6, 9.4, and 9.6% respectively). Conclusions: The analysis of the distribution of MetS suggested that what follows under the common definition of MetS is not a unique entity rather a constellation of cluster of MetS components, likely selectively risky for CV disease, whose occurrence differs across countries.
Language Style Transfer by Tianxiao Shen

This thesis studies style transfer on the basis of non-parallel text. This is an instance of a broad family of problems including machine translation, decipherment, and attribute modification. The key challenge is to separate the content from style in an unsupervised manner. We assume a shared latent content distribution across different text corpora, and propose a method that leverages refined alignment of latent representations to perform style transfer. The transferred sentences from one style should match example sentences from the other style as a population. To demonstrate the flexibility of the proposed model, we test it on three tasks: sentiment modification, decipherment of word substitution ciphers, and word order recovery. In both automatic and human evaluation our method achieves strong performance. Thesis Supervisor: Regina Barzilay Title: Professor of Electrical Engineering and Computer Science
Expression of Transcription Factor Satb2 in Adult Mouse Brain

Previous investigations on the expression and function of special AT‐rich sequence binding protein 2 (Satb2) are largely limited to the cerebral cortex. Here, we explore the expression of Satb2 thoroughly by immunohistochemistry in the adult mouse central nervous system (CNS). Besides the cerebral cortex, we found that Satb2 is specifically expressed in the bed nucleus of the stria terminalis, horizontal limb of the diagonal band, lateral hypothalamic area, arcuate nucleus, hypothalamic paraventricular nucleus, ventral tegmental nucleus, laterodorsal tegmental nucleus, dorsal raphe nucleus, rostral periolivary region, and parabrachial nucleus. Double immunostaining showed that Satb2 is exclusively expressed in the excitatory neurons of neocortex. In addition, Satb2 is specifically expressed in A12 group of hypothalamic dopaminergic neurons and in serotonergic neurons in the dorsal part of the dorsal raphe nucleus. Our results present a comprehensive overview of Satb2 expression in the adult brain and provide insights for studying the role of Satb2 in the mature CNS. Anat Rec, 296:452–461, 2013. © 2013 Wiley Periodicals, Inc.
Solid-state microcoolers and thermal energy harvesting microsystems

A thermoelectric planar microcooler was fabricated on top of a flexible substrate, using Bi<inf>2</inf>Te<inf>3</inf> and Sb<inf>2</inf>Te<inf>3</inf> thermoelectric elements. Finite element analysis and theoretical calculations previewed a temperature drop of 16 ºC in the cold area of the device. Bi<inf>2</inf>Te<inf>3</inf> and Sb<inf>2</inf>Te<inf>3</inf> materials were deposited by thermal co-evaporation on a kapton substrate, 12 μm thick. Photolithography and wet-etching were used to patterning the structures. Devices were tested by infrared imaging and results demonstrated that microsystems technology can be applied in the fabrication of thermoelectric microcoolers.
Dynamic Street Light Management: Towards a citizen centred approach

This paper presents a novel approach towards dynamic street light control, which combines advanced Information and Communication Technologies (ICT) and citizens’ involvement and engagement. Our proposal is based on the Citizens’ involvement which would strongly increases the efficiency and performance of technological solutions in smart city context. We believe that Serious Games have the potential to strengthen people motivation in this context.
Structural Details on mdm2-p53 Interaction*

Mdm2 is a cellular antagonist of p53 that keeps a balanced cellular level of p53. The two proteins are linked by a negative regulatory feedback loop and physically bind to each other via a putative helix formed by residues 18-26 of p53 transactivation domain (TAD) and its binding pocket located within the N-terminal 100-residue domain of mdm2 (Kussie, P. H., Gorina, S., Marechal, V., Elenbaas, B., Moreau, J., Levine, A. J., and Pavletich, N. P. (1996) Science 274, 948-953). In a previous report we demonstrated that p53 TAD in the mdm2-freee state is mostly unstructured but contains two nascent turns in addition to a “preformed” helix that is the same as the putative helix mediating p53-mdm2 binding. Here, using heteronuclear multidimensional NMR methods, we show that the two nascent turn motifs in p53 TAD, turn I (residues 40-45) and turn II (residues 49-54), are also capable of binding to mdm2. In particular, the turn II motif has a higher mdm2 binding affinity (∼20 μm) than the turn I and targets the same site in mdm2 as the helix. Upon mdm2 binding this motif becomes a well defined full helix turn whose hydrophobic face formed by the side chains of Ile-50, Trp-53, and Phe-54 inserts deeply into the helix binding pocket. Our results suggest that p53-mdm2 binding is subtler than previously thought and involves global contacts such as multiple “non-contiguous” minimally structured motifs instead of being localized to one small helix mini-domain in p53 TAD.
The Effective Throughput of MISO Systems Over 1 κ – μ Fading Channels

The effective throughput of multiple-input–single-output 5 (MISO) systems communicating over both independent and identically 6 distributed (i.i.d.) and independent and nonidentically distributed (i.n.i.d.) 7 κ–μ fading channels is investigated under delay constraints. New ana8 lytical expressions are derived for the exact effective throughput of both 9 channels. Moreover, we present tractable closed-form effective throughput 10 expressions in the asymptotically highand low-signal-to-noise-ratio (SNR) 11 regimes for i.i.d. κ–μ fading channels. These results enable us to investi12 gate the impact of system parameters on the effective throughput of MISO 13 κ–μ fading channels. We demonstrate that as the affordable delay tends to 14 infinity, the effective throughput is increased to the classic ergodic capacity. 15 By contrast, the effective throughput of delay-constrained near-real-time 16 systems fails to approach the ergodic capacity. 17
Risk of childhood leukaemia and non-Hodgkin's lymphoma after parental occupational exposure to solvents and other agents: the SETIL Study

Aim In the context of the Italian Multicentric Epidemiological Study on Risk Factors for Childhood Leukaemia and Non-Hodgkin's Lymphoma (SETIL), the risk of childhood cancer was investigated in relation to parental occupational exposures. Methods All cases of childhood leukaemia and non-Hodgkin's lymphoma (NHL) in children aged 0–10 years were identified. Controls were chosen at random from the local population in each region. Parents were interviewed using a structured questionnaire. The collected data were blindly reviewed by expert industrial hygienists in order to estimate exposure to a list of agents. Statistical analyses were performed for each agent using unconditional multivariable logistic regression models, taking into account timing of exposure. Results 683 cases of acute childhood leukaemia, 97 cases of NHL and 1044 controls were identified. Increased risk of childhood leukaemia was found for maternal exposure to aliphatic (OR 4.3) or aromatic hydrocarbons (OR 3.8) in the preconception period, and for paternal exposure to diesel exhaust (OR 1.4), lead exposure (OR 1.4) and mineral oils (OR 1.7). Risk of NHL appeared to be related to paternal exposure to oxygenated solvents (OR 2.5) and petrol exhaust (OR 2.2). Conclusions We found increased risk for childhood leukaemia associated with maternal occupational exposure to aromatic and aliphatic hydrocarbons, particularly in the preconception period; increased risks were also observed for paternal exposure to diesel exhaust fumes, mineral oils and lead. The risk of NHL appeared to be related to paternal exposure to oxygenated solvent and petrol exhausts.
New insights into the design for end-of-life variability of NBTI in scaled high-κ/metal-gate Technology for the nano-reliability era

In this paper, a new methodology for the assessment of end-of-life variability of NBTI is proposed for the first time. By introducing the concept of characteristic failure probability, the uncertainty in the predicted 10-year VDD is addressed. Based on this, variability resulted from NBTI degradation at end of life under specific VDD is extensively studied with a novel characterization technique. With the further circuit level analysis based on this new methodology, the timing margin can be relaxed. The new methodology has also been extended to FinFET in this work. The wide applicability of this methodology is helpful to future reliability/variability-aware circuit design in nano-CMOS technology.
Integration of Mobile Health Applications in Health Information Technology Initiatives: Expanding Opportunities for Nurse Participation in Population Health.

KEY POINTS The expansion of infrastructure to support wireless access has spurred both the adoption of mobile devices and opportunities to use such devices in addressing healthcare needs. Multiple opportunities for the use of technologies that vary in ease of design and user interface, including interactive voice response calls, short message services, and smartphones, exist across regions and markets. The combination of clinical insight and technological skills possessed by nurse informaticists enables this highly trained group to make significant contributions in the design and delivery of mHealth applications. T he potential for access to wireless technology continues to expand globally. According to estimates from the International Telecommunication Union, mobile broadband subscriptions have grown at an annual rate of 20% in the past 5 years, totaling 4.3 billion subscriptions internationally in late 2017. In developing countries, expanded fiber deployment is increasing fixed broadband speeds, as international bandwidth speeds also increase. Prices for mobile broadband subscriptions have dropped as much as 32% in some countries, and 95% of the world's population now lives in a geographical area with access to, at a minimum, a basic second-generation, or 2G, mobile wireless network. Proximity to wireless signal networks has increased the use of devices capable of connecting users to the Internet. Even in countries where there are large, sparsely populated geographic regions, such as exist in the continent of Africa (Ghana, Kenya, Nigeria, Senegal, South Africa, Tanzania, and Uganda), and where landline penetration may be close to zero in areas, the use of cell phones is growing rapidly. In this group of countries, only 17% of residents do not own a cellular phone; 35% of cellular devices owned by these residents are smartphones. Mobile technological devices with basic features, such as interactive voice response and short message service (SMS) or text messaging, along with more sophisticated devices like smartphones, are increasingly used to support and expand health information technology (HIT) initiatives designed to improve healthcare outcomes across the globe. In the United States, cellular phone devices are ubiquitous. According to a 2018 survey, 95% of adults in the United States own a cell phone, and 77% of these devices are smartphones. A third of Americans live in a home with three ormore cell phone devices, and 42%of adults 65 years or older own smartphones. While many smartphone users
Evaluating Hitting Skills of NPB Players with Logistic Regression Analysis

Luck or unluck is supposed to exist in baseball. In this paper, we consider unpredictable “lucky” or “unlucky” cases which are occurred on the ground in order to find out authentic ability of batters. If all cases are observable, hit probabilities can be calculated. However, it is impossible to gather all the information on the ground. Therefore, “luck” is defined as influence of information that cannot be observed. To provide more appropriate evaluation for NPB1 players, this paper proposes a predicted BABIP using Logistic Regression and describes the predicted BABIP reducing the influence of luck on the assessment of hitting ability. Analysis results show that there is a possibility of appropriate evaluation on hitting abilities of NPB players using the predicted BABIP.
Auditory nerve and interneurone responses to natural sounds in several species of cicadas

ABSTRACT. The calling and courtship songs of 17‐year cicadas and of Say's cicadas differ both in the sound frequency spectrum and in temporal pattern. Multiunit recordings with hook electrodes from the whole auditory nerve show that the hearing organs are especially sensitive to transient stimuli occurring in natural sounds. Artificially produced clicks elicit bursts of spikes synchronized among various primary sensory fibres. These fibres respond to natural calling and courtship songs with a specificity dependent on carrier frequency, rhythm and transient content of the sound, following sound pulses (i.e. tymbal actions) up to repetition rates of 200 Hz. An ascending, plurisegmental interneurone was characterized by intracellular recording and simultaneously stained with cobalt. Its main arborization spatially overlaps the anterior part of the sensory auditory neuropile, and the axon was traced as far as the prothoracic ganglion. Direct input from primary auditory fibres was suggested by latency measurements. Intracellular recordings from such neurons in different species show distinct auditory input, with phasic‐tonic spike responses to tones. In general, the interneurone response is more species‐specific to calling than to courtship songs, and the preferential response to the conspecific calling song is based primarily upon sound frequency content.
Title Failure Behavior of Unidirectional Composites underCompression Loading : Effect of Fiber Waviness

The key objective of this work is to highlight the effect of manufacturing-induced fiber waviness defects on the compressive failure of glass fiber-reinforced unidirectional specimens. For this purpose, in-plane, through-thickness waviness defects (with different waviness severities) are induced during the manufacturing of the laminate. Numerical and experimental results show that the compressive strength of the composites decreases as the severity of the waviness defects increases. A reduction of up to 75% is noted with a wave severity of 0.075. Optical and scanning electron microscopy observations of the failed specimens reveal that kink-bands are created in the wavy regions and lead to failure.
Optimization of grounding resistance to minimize transient currents at 150 kV SULSELRABAR system

Interference on transmission system line Sungguminasa — Tallasa led to black out (widespread outages) SULSELRABAR on Tuesday, January 19, 2016 at 14.13. The disorder occurs along with rain and high winds accompanied thunderstorms that so hard third loss burden of 746 MW. This research aims to optimize the value of grounding resistance in the event of lightning strikes and analyze the loss due to the loss of the load. The method used is to use the ATPDraw simulation and case study in areas that have experienced disruption lightning strikes in particular line Sungguminasa — Tallasa by using the paralelisasi method of copper rod. The results of this research show that the magnitude of the grounding resistance have an average voltage exceeds the limits of the capacity of the start 1001.54 kV 1042.31 kV up to, so that the occurrence of voltage impulse flashover and back with the current disruption reaches 22.65 kA. Calculation of wave running in the wake of the failure of transmission line grounding values obtained 5.4 Ω, of the value of the reflection coefficient obtained the grounding of 0.937, and voltage-on insulator worth 957, 0.36. For the measurement of tower 39 use Megger Det4tcr retrieved value grounding at the foot of the tower and 12.22 9.97 ü, the results of this research are able to attenuate the magnitude of resistance grounding in custody i. e. of 0. 78 Ω and approaching the calculation methods paralelisasi i e. 0.0864 Ω. 746 MW of load loss of the start 14.13 hours–22.00: due to black out the interference cause any harm because 37/5000 National Electricticy Company of Indonesia Rp. 8.355. 200.000,
Borrower Risk and the Price and Nonprice Terms of Bank Loans

Banks are in the business of lending to risky and hard-to-value businesses. This paper show that both the price and non-price terms of bank loans reflect observable components of borrower risk. As expected, riskier borrowers -- smaller borrowers, borrowers with less cash, and borrowers that are harder for outside investors to value -- pay more for their loans. In addition, the non-price terms of loans are systematically related to pricing; small loans, loans that are secured, and loans with relatively short maturity carry higher interest rates than other loans, even after controlling for publicly available measures of risk. This suggests that banks use both the price and non-price terms of loans as complements in dealing with borrower risk. To validate this interpretation, I also show that observably riskier firms face tighter non-price terms in their loan contracts. Loans to small firms, firms with low ratings, and firms with little cash available to service debt, for example, are more likely to be small, to be secured by collateral, and to have a short contractual maturity. Larger and more profitable firms are able to borrow on better terms across all three of these non-price dimensions.
Reducing Sequence Risk Using Trend Following and the CAPE Ratio

The risk of experiencing bad investment outcomes at the wrong time, or sequence risk, is a poorly understood but crucial aspect of the risk investors face—particularly those in the decumulation phase of their savings journey, typically over the period of retirement financed by a defined contribution pension scheme. Using US equity return data for 1872–2014, we show how this risk can be significantly reduced by applying trend-following investment strategies. We also show that knowing a valuation ratio, such as the cyclically adjusted price-to-earnings (CAPE) ratio, at the beginning of a decumulation period is useful for enhancing sustainable investment income. Disclosure: The authors report no conflicts of interest. Editor’s Note Submitted 8 September 2016 Accepted 28 April 2017 by Stephen J. Brown