Miracle-dz/UniFAR-FTUs huggingface dataset:
Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study

Abstract Objective To study the diagnosis and outcomes in people admitted to hospital with a diagnosis of severe malaria in areas with differing intensities of malaria transmission. Design Prospective observational study of children and adults over the course a year. Setting 10 hospitals in north east Tanzania. Participants 17 313 patients were admitted to hospital; of these 4474 (2851 children aged under 5 years) fulfilled criteria for severe disease. Main outcome measure Details of the treatment given and outcome. Altitudes of residence (a proxy for transmission intensity) measured with a global positioning system. Results Blood film microscopy showed that 2062 (46.1%) of people treated for malaria had Plasmodium falciparum (slide positive). The proportion of slide positive cases fell with increasing age and increasing altitude of residence. Among 1086 patients aged ≥ 5 years who lived above 600 metres, only 338 (31.1%) were slide positive, while in children < 5 years living in areas of intense transmission (< 600 metres) most (958/1392, 68.8%) were slide positive. Among 2375 people who were slide negative, 1571 (66.1%) were not treated with antibiotics and of those, 120 (7.6%) died. The case fatality in slide negative patients was higher (292/2412, 12.1%) than for slide positive patients (142/2062, 6.9%) (P < 0.001). Respiratory distress and altered consciousness were the strongest predictors of mortality in slide positive and slide negative patients and in adults as well as children. Conclusions In Tanzania, malaria is commonly overdiagnosed in people presenting with severe febrile illness, especially in those living in areas with low to moderate transmission and in adults. This is associated with a failure to treat alternative causes of severe infection. Diagnosis needs to be improved and syndromic treatment considered. Routine hospital data may overestimate mortality from malaria by over twofold.
Nonverbal Short-Term Serial Order Memory in Autism Spectrum Disorder

To clarify the role of item and order memory in the serial recall of adults with autism spectrum disorder (ASD), we carried out 2 experiments in which adults with ASD and comparison participants matched on chronological age and verbal IQ saw sequences of 7 dots appear sequentially in a 3 × 4 grid. In Experiment 1 (serial recall), they had to recall the locations and the presentation order of the dots by tapping locations on an empty grid. In Experiment 2, (order reconstruction) the studied dots were provided at test and participants had to touch them in their order of appearance at study. Experiment 1 revealed diminished item and order recall in the ASD group; Experiment 2 revealed diminished order recall only when verbal IQ was controlled. The results support the view that people with ASD have particular difficulty with serial order recall but may use their language ability to achieve better serial recall performance.
Test Case Generation and Optimization for User Session-based Web Application Testing

Web application testing is the process of revealing errors that is used to give confidence that the implementation of a Web application meets its original specification. An approach to reducing and optimizing the test cases generated from user request traces is presented. A large volume of meaningful user sessions are obtained after purging their irrelevant information by analyzing user logs on the Web server. Most of the redundant user sessions are also removed after reducing them. For test reuse and test concurrency, it divides the user sessions obtained into different groups, each of which is called a test suite, and then prioritizes the test suites and the test cases of each test suite. So, the initial test suites and test cases, and their initial executing sequences are achieved. However, the test scheme generated by the elementary prioritization is not much approximate to the best one. Therefore, genetic algorithm is further employed to optimize the results of grouping and prioritization. Meanwhile, an approach to generating new test cases is presented using crossover.
Clausthal University of Technology Heterogeneous Social Preferences

Recent research has shown the usefulness of social preferences for explaining behavior in laboratory experiments. This paper demonstrates that models of social preferences are particularly powerful in explaining behavior if they are embedded in a setting of heterogeneous actors with heterogeneous (social) preferences. For this purpose a simple model is introduced that combines the basic ideas of inequity aversion, social welfare preferences, reciprocity and heterogeneity. This model is applied to 43 games and it can be shown that its predictive accuracy is clearly higher than that of the isolated approaches. Furthermore, it can explain most of the “anomalies” (the “contradictions”) that are discussed in Goeree and Holt (2001). JEL-Classification: C72, C92, D63 * Institute of Business Administration and Economics, Clausthal University of Technology, Julius-Albert-Str. 2, 38678 Clausthal-Zellerfeld, Germany, m.erlei@tu-clausthal.de. # For helpful comments I wish to thank Heike Schenk-Mathes, J. Philipp Siemer and Jens-Peter Springmann.
Heat‐shock induction of T‐cell lymphoma/leukaemia in conditional Cre/lox‐regulated transgenic zebrafish

The zebrafish is an ideal vertebrate model system to investigate the complex genetic basis of cancer because it has the capacity for in vivo tumour‐cell imaging and forward genetic screens, and the molecular mechanisms regulating malignancy are remarkably conserved when compared with human. Our laboratory has previously generated transgenic zebrafish models that overexpress the mouse c‐Myc gene fused to enhanced green fluorescent protein (EGFP) and develop T‐cell acute lymphoblastic leukaemia (T‐ALL) that recapitulates the human disease both molecularly and pathologically. Our previous models have been limited by disease onset prior to sexual maturity and by the low disease penetrance when conditional transgenic embryos are injected with Cre RNA. Here, we report a novel system in which compound transgenic fish expressed both Cre controlled by the heat‐shock promoter and a rag2‐promoter‐regulated lox‐dsRED2‐lox‐EGFP‐mMyc cassette rag2‐LDL‐EMyc in developing T cells. After heat‐shock treatment at 3 d postfertilisation (dpf) for 45 min at 37°C, 81% of compound transgenic fish developed T‐lymphoblastic lymphoma (T‐LBL, mean latency 120 ± 43 (standard deviation) days of life), which rapidly progressed to T‐ALL. Heat‐shock‐regulated transgenic technology in zebrafish provides the missing link necessary to exploit the powerful genetic capacity of this organism to probe the multi‐step molecular pathogenesis of leukaemia.
Media representation of the UK as a destination for Japanese tourists

Representations and images of tourist destinations constructed by popular cultural forms of media such as films, television and literature play a significant role in influencing people’s holiday decision-making process. This article illustrates the significance of media representations of destinations based upon findings from the author’s survey of Japanese tourists to the UK and briefly examines popular images of the UK created in the film Harry Potter and the Philosopher’s Stone, the television series of Sherlock Holmes, and Beatrix Potter’s Peter Rabbit stories, all of which were identified as influential in the survey. It suggests that the ways in which the UK is represented in those media works have implications for the ways in which Japanese tourists define the UK as a destination and the character of the British. Thus, popular cultural forms of the media can promote, confirm and reinforce particular images, views, and identities of destinations in a very powerful manner.
A computerized provider order entry intervention for medication safety during acute kidney injury: a quality improvement report.

BACKGROUND Frequently, prescribers fail to account for changing kidney function when prescribing medications. We evaluated the use of a computerized provider order entry intervention to improve medication management during acute kidney injury. STUDY DESIGN Quality improvement report with time series analyses. SETTING & PARTICIPANTS 1,598 adult inpatients with a minimum 0.5-mg/dL increase in serum creatinine level over 48 hours after an order for at least one of 122 nephrotoxic or renally cleared medications. QUALITY IMPROVEMENT PLAN Passive noninteractive warnings about increasing serum creatinine level appeared within the computerized provider order entry interface and on printed rounding reports. For contraindicated or high-toxicity medications that should be avoided or adjusted, an interruptive alert within the system asked providers to modify or discontinue the targeted orders, mark the current dosing as correct and to remain unchanged, or defer the alert to reappear in the next session. OUTCOMES & MEASUREMENTS Intervention effect on drug modification or discontinuation, time to modification or discontinuation, and provider interactions with alerts. RESULTS The modification or discontinuation rate per 100 events for medications included in the interruptive alert within 24 hours of increasing creatinine level improved from 35.2 preintervention to 52.6 postintervention (P < 0.001); orders were modified or discontinued more quickly (P < 0.001). During the postintervention period, providers initially deferred 78.1% of interruptive alerts, although 54% of these eventually were modified or discontinued before patient death, discharge, or transfer. The response to passive alerts about medications requiring review did not significantly change compared with baseline. LIMITATIONS Single tertiary-care academic medical center; provider actions were not independently adjudicated for appropriateness. CONCLUSIONS A computerized provider order entry-based alerting system to support medication management after acute kidney injury significantly increased the rate and timeliness of modification or discontinuation of targeted medications.
Notice of RetractionEmpirical study of IDF on text classification dataset

This paper observes and analyses IDF and it's properties on the best TC dataset. We checkout the Zipf law of occuring frequence(OF) and document frequence(DF) of features. And we pay much attention to the validity of order relationship based on OF and DF, then conclude that order relationship based on linear combination of OF and DF may be more informative. Our observation shows that IDF has little ability of category recognization and contribute a little to text when used by itself only. It seems that the novelty or expressive force of a feature can be formulated as the linear combination of IDF, average occuring frequence and it`s standard deviation.
A Novel Virtual Force Approach for Node Deployment in Wireless Sensor Network

The effectiveness of wireless sensor networks (WSN) depends on the coverage and connectivity provided by node deployment, which is one of the key topics in WSN. In this paper, a modified virtual force-based node self-deployment algorithm for nodes with mobility is proposed. In the virtual force-based approach, all nodes are seen as points subject to repulsive and attractive force exerted among them, nodes can move according to the calculated force. In the proposed approach, Delaunay triangulation is formed with these nodes, adjacent relationship is defined if two nodes are connected in the Delaunay diagram. Force can only be exerted from those adjacent nodes within the communication range. Simulation results showed that the proposed approach has higher coverage rate and faster convergence time than traditional virtual force algorithm.
COHORT AND PREJUDICE WHITES' ATTITUDES TOWARD BLACKS, HISPANICS, JEWS, AND ASIANS

Recent cohorts have been shown to be less prejudiced than their elders, at least toward blacks. This study addresses two questions: Has this tendency continued among most-recent cohorts of adults? and Does it extend to prejudice toward other ethnic minorities? Using data from a national sample, I focus on stereotype and social distance attitudes pertaining to blacks, Hispanics, Asians, and Jews. In general, results indicate that cohorts born after World War II tend to be less prejudiced than prewar cohorts toward each of the four minorities. But most- recent cohorts of Americans show no tendency to be less preju- diced than their immediate predecessors born since World War II, and most-recent cohorts residing outside of the South actually tend to be more prejudiced than their elders. Past research shows that younger cohorts of adults are less prejudiced, a cause for optimism about the future of intergroup relations. As more recent, less prejudiced cohorts replace earlier, more prejudiced co- horts, overall prejudice levels will decline. But the conservative shift in America during the 1980s considered in light of Mannheim's ((1928) 1952) theory of generations, along with recent findings showing that cohorts most recently come of age are no less prejudiced than their predecessors, supports a more pessimistic view. Following a review of this material, I present a new study of cohort and prejudice toward four minority groups: blacks, Jews, Hispanics, and Asians. Results provide no evidence of a general tendency for most-recent cohorts to be less prejudiced, and little reason for opti- mism about future declines in prejudice resulting from cohort succes- sion.
Patient Related Outcome Measures Dovepress a Systematic Literature Review to Compare Quality of Life in Psoriasis with Other Chronic Diseases Using Eq-5d-derived Utility Values

Background: Psoriasis is a chronic, immune-mediated dermatological disease associated with substantial economic, clinical, and humanistic burden. Objective: The aim of this study was to understand the disutility of patients with psoriasis vulgaris, using mean baseline EuroQoL five dimensions (EQ-5D) index scores reported in the published literature, and to compare this to patients with other chronic diseases. Methods: Two systematic literature searches were conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Searches were conducted in ten databases including Embase, MEDLINE, and the Cochrane Central Register of Controlled Trials (CENTRAL). The first search (December 2013) used search terms psoria* AND (EQ5D OR EQ OR EUROQoL). Only publications of original research, which reported baseline EQ-5D scores for mild/moderate/severe psoriasis, were included. The second search (March 2014) used the terms (systematic review) AND (EQ5D OR EQ 5D OR EuroQoL). Titles were screened by two independent reviewers. Four independent reviewers reviewed titles and full-length papers. EQ-5D scores for psoriasis patients were qualitatively compared with scores from patients with other chronic diseases identified through the literature search. Results: Of 133 publications on psoriasis, 12 met the inclusion criteria. The mean EQ-5D index scores for psoriasis (all severities) ranged from 0.52 (standard deviation: 0.39) to 0.9 (standard deviation: 0.1). Of the 48 results from the second search, six met the inclusion criteria. The reported EQ-5D lower limit for other diseases ranged from 0.20 (Type 2 diabetes mellitus) to 0.66 (liver diseases). The highest EQ-5D estimates for other diseases ranged from 0.79 (liver diseases) to 0.93 (cancer patients). Both lower and upper EQ-5D estimates in psoriasis patients were within the range of those reported for other chronic diseases. Conclusion: Comparative studies of morbidity are relevant in health care studies and patient advocacy. This systematic review demonstrates that the ranges of disutility among psoriasis patients are within the ranges of other chronic diseases (cardiovascular diseases, diabetes, end-stage renal diseases, liver diseases, cancer, and visual disorders).
Cleavage of Focal Adhesion Kinase by Caspases during Apoptosis*

Apoptotic cells undergo characteristic morphological changes that include detachment of cell attachment from the substratum and loss of cell-cell interactions. Attachment of cells to the extracellular matrix and to other cells is mediated by integrins. The interactions of integrins with the extracellular matrix activates focal adhesion kinase (FAK) and suppresses apoptosis in diverse cell types. Members of the tumor necrosis family such as Fas and Apo-2L, also known as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), induce apoptosis in both suspension and adherent cells through the activation of caspases. These caspases, when activated, cleave substrates that are important for the maintenance of nuclear and membrane integrity. In this study, we show that FAK is sequentially cleaved into two different fragments early in Apo-2L-induced apoptosis. We also demonstrate that FAK cleavage is mediated by caspases and that FAK shows unique sensitivity to different caspases. Our results suggest that disruption of FAK may contribute to the morphological changes observed in apoptotic suspension and adherent cells.
Can leisure activities slow dementia progression in nursing home residents? A cluster-randomized controlled trial

ABSTRACT Background: To examine the effects of complex cognitive (mahjong) and physical (Tai Chi) activities on dementia severity in nursing home residents with dementia. Methods: Cluster-randomized open-label controlled design. 110 residents were randomized by nursing home into three conditions: mahjong, Tai Chi, and simple handicrafts (control). Activities were conducted three times a week for 12 weeks. Clinical Dementia Rating (CDR) was taken at 0 (baseline), 3 (post-treatment), 6, and 9 months. The outcome measure was CDR sum-of-box, which is a composite measure of both cognitive and functional deterioration in dementia. Results: Intent-to-treat analyses were performed using multilevel regression models. Apolipoprotein E ε4 allele and education were included as covariates. Neither treatments had effects on the cognitive and functional components of the CDR, but mahjong had a significant interaction with time on the CDR sum-of-box total, suggesting a slower rate of global deterioration in the mahjong group as compared with the control group. Conclusions: Mahjong led to a gradual improvement in global functioning and a slightly slower rate of dementia progression over time. The effect was generalized and was not specific to cognition or daily functioning.
Variability Mitigation Mechanisms in Scaled 3T1D-DRAM Memories to 22 nm and Beyond

It has been stated that 3T1D-DRAM cell is a valid alternative to be implemented on L1 memory cache to substitute 6T, highly affected by variability. In this paper, it is shown that the 3T1D memory cells present significant tolerance to high levels of device parameter fluctuation when they are scaled to nodes smaller than 22 nm. Furthermore, we present some strategies to mitigate the cell variability. Moreover, while scaling down capacitorless DRAM cells is a challenging trend, we also show how the scaling drawbacks can be compensated through the following: 1) the channel strain of the cell devices and 2) the proposal of new strategies to further enhance the memory cell behavior.
Alfvén Waves and Turbulence in the Solar Atmosphere and Solar Wind

We solve the problem of propagation and dissipation of Alfvénic turbulence in a model solar atmosphere consisting of a static photosphere and chromosphere, transition region, and open corona and solar wind using a phenomenological model for the turbulent dissipation based on wave reflection. We show that most of the dissipation for a given wave-frequency spectrum occurs in the lower corona, and the overall rms amplitude of the fluctuations evolves in a way consistent with observations. The frequency spectrum for a Kolmogorov-like slope is not found to change dramatically from the photosphere to the solar wind; however, it does preserve signatures of transmission throughout the lower atmospheric layers, namely, oscillations in the spectrum at high frequencies reminiscent of the resonances found in the linear case. These may disappear once more realistic couplings for the nonlinear terms are introduced or if time-dependent variability of the lower atmospheric layer is introduced.
Structural Model for Osteoporosis Preventing Behavior in Postmenopausal Women

Background: Osteoporosis prevention behaviors (OPBs) can prevent and delay bone deterioration; dual-energy X-ray absorptiometry (DXA) scan can identify osteoporosis and provide personal osteoporosis risk information that may promote prevention behaviors. Objectives: This study was designed to estimate relationships between receiving personal knowledge of bone mineral density (gained through DXA scan), general knowledge of osteoporosis, health beliefs, and the two OPBs of calcium intake and weight-bearing exercise in healthy postmenopausal women 50 to 65 years. Methods: In this longitudinal, randomized clinical trial (including covariates), receipt of personal DXA information was manipulated by random assignment to the experimental or control group. The remaining antecedent and outcome variable measures were collected by questionnaire at three time points (initial [T1; pre-DXA], 6 months [T2], 12 months [T3]) and by bone density assessment from 203 women over an 18-month period in 2001-2003. Results: The experimental manipulation (DXA results) had a direct positive effect (&bgr; = .23, p < .05) on calcium intake at T2, and indirectly at T3 through T2. Women in the experimental group who were informed they had osteopenia or osteoporosis had a greater T1-T2 change in daily calcium intake than those with normal bone density (&bgr; = .23, p < .05). However, providing DXA results did not relate to change in exercise. Health beliefs and general osteoporosis knowledge predicted initial calcium and exercise levels; there was tentative evidence that susceptibility beliefs partially mediate between DXA results and change in calcium intake. Discussion: Personal knowledge of DXA results was related significantly to increases in calcium intake in postmenopausal women, but not to exercise. Directions for further study are discussed.
An Asynchronous Striping-Aware Readahead Framework for Disk Arrays in Linux

Disk arrays and prefetching schemes are used to mitigate the performance gap between main memory and disks. This paper presents a new problem that arises if prefetching schemes that are widely used in operation systems are applied to disk arrays. The key point of the problem is that block address space from the viewpoint of the host is contiguous but from that of the disk array it is discontiguous and thus more disk accesses than expected are required. This paper presents two ways to resolve the problem that arises from the Linux readahead framework. The proposed scheme prevents a readahead window from being split into multiple requests from the viewpoint of the disk array but not from the viewpoint of the host thereby reducing disk head movements. In addition, it outperforms the prior work by adopting an asynchronous solution, improving performance for fragmented files, eliminating readahead size restriction, and improving disk parallelism. We implemented the proposed scheme and integrated it with Linux. Our experiment shows that the solution significantly improved the original Linux readahead framework when a storage server processes multiple concurrent requests.