Miracle-dz/UniFAR-FTUs huggingface dataset:
Infant home respiratory monitoring using pulse oximetry

Respiratory rate (RR) is a valuable early marker of illness in vulnerable infants, but current monitoring methods are unsuitable for sustained home use. We have demonstrated accurate measurement of RR from brief recordings of pulse oximeter plethysmogram (pleth) trace in full-term neonates in hospital. This study assessed the feasibility of this method in preterm infants during overnight recordings in the home. We collected simultaneous overnight SpO2, pleth and respiratory inductive plethysmography (RIP) on 24 preterm infants in the home. RR from pleth analysis was compared with RR from RIP bands; pleth quality was assessed by the presence of visible artefact. Median (range) RR from RIP and pleth were not significantly different at 42 (25–65) and 42 (25–64) breaths/min. Median (range) % of epochs rejected due to artefact was 20 (8–75) for pleth and 10 (3–53) for RIP. Our results suggest that home RR monitoring by pulse oximeter pleth signal is accurate and feasible.
Optimal Location of Shunt FACTS Devices for First-Swing Stability Enhancement in Inter-Area Power System

This paper deals with the location of shunt FACTS devices to improve transient stability in a long transmission line with predefined direction of real power flow. Shunt Flexible AC Transmission System (FACTS) devices, when placed at the midpoint of a long transmission line, play an important role in controlling the reactive power flow to the power network and hence both the system voltage fluctuations and transient stability. The validity of the mid-point location of shunt FACTS devices was verified using Simulink, with different shunt FACTS devices, namely static var compensator (SVC) and static synchronous compensator (STATCOM) in a long transmission line using the actual line model. It has been observed that the FACTS devices, when placed slightly off-centre towards sending-end, give better performance in improving transient stability and the location depends on the amount of local/through load. The results are experimented and simulated on MATLAB/Simulink environment.
Convexity inequalities for estimating free energy and relative entropy

For quantum systems, it is shown that the relative entropy S(P,Q)=-Tr P log P+Tr P log Q of two positive semi-definite operators P and Q satisfies gamma -1 Tr(P-P1+ gamma Q- gamma )<or=S(P,Q)<or= gamma -1 Tr(P1- gamma Qgamma -P) for 0( gamma <or=1, and that these bounds become exact in the limit gamma to Phi . Analogous inequalities hold, for states in classical statistical mechanics or information theory, with trace replaced by integration or summation. Furthermore, the average of these bounds is, in general a better approximation to S(P,Q) than either bound alone, and the average is amenable to further improvement via repeated Richardson extrapolation. IF P and Q are Gibbs equilibrium states, then these inequalities can also be used to obtain bounds on the free energy of a perturbed system in terms of the free energy of the unperturbed system and expectations of the perturbation.
Traffic-Aware Optimal Spectrum Sensing Policy in Wireless-Powered Cognitive Radio Networks

We consider an orthogonal frequency division multiple access (OFDMA)-based primary user (PU) network model which offers different spectral access and energy harvesting opportunities in wireless-powered cognitive radio networks (CRNs). In this setting, we propose a traffic-aware optimal spectrum sensing policy for opportunistic spectrum access and energy harvesting under the energy causality and PU collision constraints in the wireless-powered CRNs. PU channels carry different traffic patterns and show distinct idle/busy frequencies, and hence the spectral access and energy harvesting opportunities are application specific. Secondary user (SU) obtains traffic pattern information through observation of PU channels and classifies the idle/busy period statistics for each channel using the variational inference approach. Based on the statistics, we adopt a stochastic model for evaluating SU capacity by which the energy detection threshold for spectrum sensing can be found with higher sensing accuracy. Towards this, we formulate the Markov decision process (MDP) model obtained by quantizing the amount of SU battery. The effectiveness of the proposed stochastic model is confirmed through comparison with the optimal one obtained from an exhaustive method.
Vemurafenib in Langerhans cell histiocytosis: report of a pediatric patient and review of the literature

Selective BRAF inhibitors such as vemurafenib have become a treatment option in patients with Langerhans cell Histiocytosis (LCH). To date, only 14 patients receiving vemurafenib for LCH have been reported. Although vemurafenib can stabilize the clinical condition of these patients, it does not seem to cure the patients, and it is unknown, when and how to stop vemurafenib treatment. We present a girl with severe multisystem LCH who responded only to vemurafenib. After 8 months of treatment, vemurafenib was tapered and replaced by prednisone and vinblastine, a strategy which has not been described to date. Despite chemotherapy, early relapse occurred, but remission was achieved by re-institution of vemurafenib. Further investigation needs to address the optimal duration of vemurafenib therapy in LCH and whether and which chemotherapeutic regimen may prevent disease relapse after cessation of vemurafenib.
Objective tumour heterogeneity determination in gliomas

Diffusion weighted imaging (DWI) derived apparent diffusion coefficient (ADC) values are known to correlate inversely to tumour cellularity in brain tumours. The average ADC value increases after successful chemotherapy, radiotherapy or a combination of both and can be therewith used as a surrogate marker for treatment response. Moreover, high and low malignant areas can be distinguished. The main purpose of our project was to develop a software platform that enables the automated delineation and ADC quantification of different tumour sections in a fast, objective, user independent manner. Moreover, the software platform allows for an analysis of the probability density of the ADC in high and low malignant areas in ROIs drawn on conventional imaging to create a ground truth. We tested an Expectation Maximization algorithm with a Gaussian mixture model to objectively determine tumour heterogeneity in gliomas because of yielding Gaussian distributions in the different areas. Furthermore, the algorithm was initialized by seed points in the areas of the gross tumour volume and the data indicated that an automatic initialization should be possible. Thus automated clustering of high and low malignant areas and subsequent ADC determination within these areas is possible yielding reproducible ADC measurements within heterogeneous gliomas.
Screening and identification of molecular markers for genetic diversity among Cowpea genotypes

Cowpea is highlyproteinaceous and it is also tolerant to drought and acidic soil. Consequently, it is a best source to satisfy the food demand of escalating population of the world. For the study of genetic diversity mostly molecular markers are being used. ISSR markers are highly variable in the genome and also reproducible and cost effective. Therefore, it is the perfectmarker for the genetic diversity analysis. There were 52 ISSR primers in which 2 primers i.e. UBC807, UBC812 were scorableon agarose gel and showed polymorphism. UBC807 used for the identification of the line Babita (BB) and shows 810bp polymorphic band. To identify the line Lali (LL) Primer UBC812 was used and shows 600bp polymorphic band.These highly informative primers easily differentiated the parent genotypes.Genetic diversity helps the plant breeders to select lines which improve the food security.
A multifaceted approach to RSV vaccination

ABSTRACT Respiratory Syncytial Virus (RSV) is the leading cause of pneumonia and bronchiolitis in infants, resulting in significant morbidity and mortality worldwide. In addition, RSV infections occur throughout different ages, thus, maintaining the virus in circulation, and increasing health risk to more susceptible populations such as infants, the elderly, and the immunocompromised. To date, there is no vaccine approved to prevent RSV infection or minimize symptoms of infection. Current clinical trials for vaccines against RSV are being carried out in four very different populations. There are vaccines that target two different pediatric populations, infants 2 to 6 month of age and seropositive children over 6 months of age, as well as women (non-pregnant or pregnant in their third trimester). There are vaccines that target adult and elderly populations. In this review, we will present and discuss RSV vaccine candidates currently in clinical trials. We will describe the preclinical studies instrumental for their advancement, with the goal of introducing new preclinical models that may more accurately predict the outcome of clinical vaccine studies.
Nexus between business process management (BPM) and accounting: A literature review and future research directions

Purpose Multidisciplinary business process management (BPM) research can reap significant impact. We can particularly benefit from incorporating accounting concepts to address some of the key BPM challenges, such as value-creation and return on investment of BPM activities. However, research which addresses a relationship between BPM and accounting is scarce. The purpose of this paper is to provide a detailed synthesis of the current literature that has integrated accounting aspects with BPM. The authors profile and thematically describe existing research, and derive evidence-based directions to guide future research. Design/methodology/approach A multi-staged structured literature review approach to search for the two broad themes, accounting and BPM, supported by NVivo (to manage the papers and the coding and analysis processes) was designed and followed. Findings The paper confirms the dearth of work that ties the two disciplines, despite the synergetic multidisciplinary results that can be attained. Available literature is mostly from the management accounting perspective and relates to describing how performance management, in particular performance measurement, can be applicable to process improvement initiatives together with tools such as activity-based costing and the balanced scorecard. There is a lack of research that examines BPM in relation to any financial accounting perspectives (such as external reporting). Future research directions are proposed together with implications for practitioners with the findings of this structured literature review. Research limitations/implications The paper provides a detailed synthesis of the existing literature on the nexus between accounting and BPM. It summarizes the implications for practitioners and provides directions for future research by identifying key gaps and opportunities with a sound contextual basis for extension and new work. Originality/value Effective literature reviews create strong foundations for future research and accumulate the otherwise scattered knowledge into a single place. This is the first structured literature review that provides a detailed synthesis of the research that ties together the accounting and BPM disciplines, providing a basis for future research directions together with implications for practitioners.
Changes in the amino acid profiles and free radical scavenging activities of Tenebrio molitor larvae following enzymatic hydrolysis

Tenebrio molitor (T. molitor) larvae provide food at low environmental cost and contribute positively to livelihoods. In this research, we compared the amino acids compositions and antioxidant activities of various extracts of T. molitor to enhance their quality as food. For the comparison, distilled water extracts, enzymatic hydrolysates, and condensed enzymatic hydrolysates of T. molitor larvae were prepared. Their amino acids (AAs) profiles and antioxidant activities, including ferric-reducing antioxidant power, oxygen radical absorption capacity, and DPPH, hydroxyl radical, and hydrogen peroxide radical scavenging properties assay were analyzed. DW extracts had the lowest AAs contents and antioxidant activity compared with enzymatic extracts. Condensed hydrolysates with a combination of alcalase and flavourzyme (C-A+F) exhibited the highest levels of total free AAs (11.1759 g/100 g). C-A+F produced higher total hydrolyzed AAs (32.5292 g/100 g) compared with the other groups. The C-A+F possessed the strongest antioxidant activity. Notably, the antioxidant activities of the hydrolysates and the total hydrolyzed AAs amount were correlated. Taken together, our findings showed that C-A+F was a promising technique for obtaining extracts of T. molitor larvae with antioxidant activity as potential nutritious functional food.
Revisiting the Task of Scoring Open IE Relations

Knowledge Base Completion infers missing facts from existing ones in knowledge bases. As recent Open Information Extraction systems allow us to extract ever larger (yet incomplete) open-domain Knowledge Bases from text, we seek to probabilistically extend the limited coverage we get from existing facts, to arbitrary queries about plausible information. We propose a simple baseline, based on language modeling and trained with off-the-shelf programs, which gives competitive results in the previously deﬁned protocol for this task, and provides an independent source of signal to judge arbitrary fact plausibility. We reexamine this protocol, measure the (large) impact of the negative example generation procedure, which we ﬁnd to run contrary to the belief put forward in previous work. We conduct a small manual evaluation, giving insights into the rudimentary automatic evaluation protocol, and analyse the shortcomings of our model.
A Novel Secretory Vesicle from Deer Antlerogenic Mesenchymal Stem Cell-Conditioned Media (DaMSC-CM) Promotes Tissue Regeneration

Multipotent stem cells have the capacity to generate terminally differentiated cell types of each lineage; thus, they have great therapeutic potential for a wide variety of diseases. The most widely available stem cells are derived from human tissues, and their use for therapeutic application is limited by their high cost and low productivity. Herein, we report that conditioned media of mesenchymal stem cells (MSCs) isolated from deer antlers enhanced tissue regeneration through paracrine action via a combination of secreted growth factors and cytokines. Notably, DaMSC-conditioned media (DaMSC-CM) enhanced hair regeneration by activating the Wnt signaling pathway. In addition, DaMSC-CM had regenerative potential in damaged skin tissue through induction of skin regeneration-related genes. Remarkably, we identified round vesicles derived from DaMSC-CM, with an average diameter of ~120 nm that were associated with hair follicle formation, suggesting that secretory vesicles may act as paracrine mediators for modulation of local cellular responses. In addition, these secretory vesicles could regulate the expression of Wnt-3a, Wnt-10b, and lymphoid enhancer-binding factor-1 (LEF-1), which are related to tissue renewal. Thus, our findings demonstrate that the use of DaMSC-CM as a unique natural model for rapid and complete tissue regeneration has possible application for therapeutic development.
ISSN: 2249-0353 Review Article OXIDATIVE STRESS, BIOMARKERS AND ANTIOXIDANTS RELEVANT TO PROSTATE CANCER AND NEURODEGENERATION: POTENTIAL ROLE OF QUERCETIN

Oxidative stress is a key impairment induced by several conditions including cardiac problems, liver disorders, cancer and neurodegenerative disorders. The cell has numerous protective defense mechanisms against threating factors. Most cells can tolerate a mild degree of oxidative stress because they have sufficient antioxidant defense mechanisms. Physiological levels of Reactive oxygen species (ROS) are beneficial for cells. Many components of the cell such as mitochondria, endoplasmic reticulum, peroxisomes, membranes and cytosol can be source of ROS. In general, there is a balance between production of ROS and cellular antioxidant agents. If the amount of ROS increases and if these products destroy the apparatus by which antioxidant agents are produced, the cellular defense system is eventually incapacitated. The dietary antioxidants such as ascorbic acid, α-tocopherol, lycopene, and quercetin have protective properties of oxidative stress and damage. This review presents an extensive analysis of key findings from studies on the dietary antioxidants such as ascorbic acid, α-tocopherol, lycopene, quercetin against prostate cancer; neurodegenerative situation in selected brain regions, PCB induced oxidative damage in testicular Leydig and Sertoli cellular, ventral prostatic, epididymal, liver and kidney functions. This research is also leading to identification of novel drug targets. © 2013 Universal Research Publications. All rights reserved
Detection of Low Pathogenicity Influenza A(H7N3) Virus during Duck Mortality Event, Cambodia, 2017

In January 2017, an estimated 3,700 (93%) of 4,000 Khaki Campbell ducks (Anas platyrhynchos domesticus) died in Kampong Thom Province, Cambodia. We detected low pathogenicity avian influenza A(H7N3) virus and anatid herpesvirus 1 (duck plague) in the affected flock; however, the exact cause of the mortality event remains unclear.
Temperament, reward and punishment sensitivity, and clinical disorders: Implications for behavioral case formulation and therapy

Recent research in psychology, psychiatry and neuroscience has demonstrated reliable associations between temperament and individual differences in sensitivity and responsiveness to environmental cues and behavioral consequences. Temperament–influenced behavior patterns evident in infancy have also been found to predict behavioral tendencies in adulthood. Such observations suggest that neurophysiological structures and physiological events associated with temperament concepts exert a mediating or moderating influence between current environmental events and behavior. This paper summarizes relevant research on individual differences in sensitivity and responsiveness to environmental cues and behavioral consequences with reference to Jeffrey Gray’s neuropsychological theory of temperament. Implications of temperament research for behavioral case formulation and therapy are described.
Gradient-domain processing within a texture atlas

Processing signals on surfaces often involves resampling the signal over the vertices of a dense mesh and applying mesh-based filtering operators. We present a framework to process a signal directly in a texture atlas domain. The benefits are twofold: avoiding resampling degradation and exploiting the regularity of the texture image grid. The main challenges are to preserve continuity across atlas chart boundaries and to adapt differential operators to the non-uniform parameterization. We introduce a novel function space and multigrid solver that jointly enable robust, interactive, and geometry-aware signal processing. We demonstrate our approach using several applications including smoothing and sharpening, multiview stitching, geodesic distance computation, and line integral convolution.
Association of Factor V Leiden Mutation with Delayed Graft Function, Acute Rejection Episodes and Long-term Graft Dysfunction in Kidney Transplant Recipients

Summary We analysed whether the factor V Leiden mutation – the most common hereditary predisposing factor for venous thrombosis – is associated with early and long-term graft dysfunction after kidney transplantation in 394 Caucasian kidney transplant recipients. The presence of factor V Leiden mutation was identified by allele specific PCR. The prevalence of the factor V Leiden mutation was compared to 32216 unselected neonates. The prevalence of the factor V Leiden mutation (GA genotype) was similar in 394 kidney transplant recipients and 32216 neonates. The frequency of known factors predicting long-term graft function were similar in patients with the GA genotype and with the normal factor V gene (GG genotype). The GA genotype was associated with the occurrence of no primary graft function (risk: 2.87; 95% confidence interval: 1.01-8.26; p < 0.05), the number of dialysis after transplantation in patients with no primary graft function until graft function (7.5 ± 2.06 dialysis in GA patients; 4.2 ± 0.36 dialyses in GG patients; p < 0.05), and the risk for at least one acute rejection episode (risk: 3.83; 95% confidence interval: 1.38-10.59; p < 0.02). The slope of 1/creatinine per year was significantly lower in patients with the GA genotype (GA patients: – 0.0204 ± 0.008 dl/mg per year; GG patients: 0.0104 ± 0.004 dl/mg per year; p < 0.02). The annual enhancement of the daily protein excretion rate was elevated in patients with the GA genotype (GA patients: 38.5 ± 16.6 mg/24 h per year; GG patients: 4.9 ± 4.4 mg/24 h per year; p < 0.02). Our study showed that the factor V Leiden mutation is associated with the occurrence of delayed graft function, acute rejection episodes and chronic graft dysfunction after kidney transplantation.
Delivering Better Government: Assessing the Effectiveness of Public Sector Organizations

This paper assesses the effectiveness of public sector organizations (PSOs) by employing a framework of effectiveness, efficiency, relevancy and creativity (EERC). However, this particular paper assesses only the effectiveness dimension of organizational performance; the three remaining dimensions are outside of its ambit. While discussing the above, public sector training institutes (PSTIs) were used for illustrative purposes. Four sets of questionnaires focusing on four different target groups were developed to collect pertinent data. Results show that PSTIs are not realizing their objectives and that their training programs are not consistent with the policy objectives and trainees’ needs, thus scoring low on effectiveness. It is hoped that the findings of the study will have practical implications for trainees, PSTIs, policy makers and on many other on-going performances-oriented policies and programs to improve the effectiveness of PSOs.
Effects of E-government strategy on service delivery in the government ministries in Kenya

E-government involves using ICTs to transform both back-end and front-end government processes and provides services, information and knowledge to the public. The emergence of Information and Communication Technology has provided means for faster and better communication, efficient storage, retrieval and processing of data and exchange and utilization of information to its users, be they individuals, groups, businesses, organizations or governments. The objective of the study was to investigate the effects of e-government strategy on service delivery in the government ministries. The study adopted a descriptive survey research design. The target population comprised of all Government Ministries in Kenya were by census was conducted. The data was collected using questionnaires which comprised of both open and closed ended questions. The data was analyzed using Statistical Package for Social Sciences (SPSS) and presented in the form of tables, frequencies and percentages. The research findings revealed that implementation of e-government were not effective in all Ministries. The study revealed that use of e-government enabled database sharing, lowered the costs of delivering services, reduced time taken to process a transaction, lead to improved management of records, eased working procedure and improved staff productivity. The study revealed the existence of overcrowding in ministries, and inability by citizens to access facilities online. The study recommends enactment of policies aimed at regulating of e-government implementation. the study recommend that management teams responsible for e-government implementation at the ministries should ensure that the egovernment implementation process leads to promoting online access of facilities by the citizen as well as reducing overcrowding in the Ministries.