Miracle-dz/UniFAR-FTUs huggingface dataset:
Real-Time Gas Identification by Analyzing the Transient Response of Capillary-Attached Conductive Gas Sensor

In this study, the ability of the Capillary-attached conductive gas sensor (CGS) in real-time gas identification was investigated. The structure of the prototype fabricated CGS is presented. Portions were selected from the beginning of the CGS transient response including the first 11 samples to the first 100 samples. Different feature extraction and classification methods were applied on the selected portions. Validation of methods was evaluated to study the ability of an early portion of the CGS transient response in target gas (TG) identification. Experimental results proved that applying extracted features from an early part of the CGS transient response along with a classifier can distinguish short-chain alcohols from each other perfectly. Decreasing time of exposition in the interaction between target gas and sensing element improved the reliability of the sensor. Classification rate was also improved and time of identification was decreased. Moreover, the results indicated the optimum interval of the early transient response of the CGS for selecting portions to achieve the best classification rates.
Evaluation of Minimum Karst Spring Discharge Using a Simple Rainfall-Input Model: The Case Study of Capodacqua di Spigno Spring (Central Italy)

The increasing occurrence of widespread drought phenomena is a global environmental emergency, especially for the effects of ongoing climate change on groundwater availability. Dry years and extreme temperatures are common drivers of current climate impacts all over the world, including, for example, the freshwater supply for drinking and agriculture purposes, ecosystems, forestry, health, etc. In this frame, to ensure temporal water availability in water-stressed areas, sustainable groundwater management is an increasing challenge. Most groundwater in the South-East Latium Region, Central Italy, as in the whole Apennine Mountains chain, is stored in karst aquifers. In this area important water resources are present, but even here in the last decades they are affected by groundwater depletion as a consequence of occurring drought events, the upward trend in the global average temperature and the increase in groundwater extraction. Due to the lack of flow rate data of springs in many areas of Italy, spring response modeling could be a useful tool for supporting proper water resource management. Several research studies proposed methods based on relationships between spring discharges and rainfall data. The goal of this paper is to propose a simple linear model, based on rainfall-discharge cross correlations, in order to be able to simulate the effects of variation in rainfall on water resource connected Capodacqua di Spigno Spring minimum discharge. The results obtained using the developed model has been compared to an existing method that uses the Standard Precipitation Index (SPI) for the estimation of the minimum annual spring discharge.
Phosphorylation causes subtle changes in solvent accessibility at the interdomain interface of methylesterase CheB.

The crystal structure of the unphosphorylated state of methylesterase CheB shows that the regulatory domain blocks access of substrate to the active site of the catalytic domain. Phosphorylation of CheB at Asp56 results in a catalytically active transiently phosphorylated enzyme with a lifetime of approximately two seconds. Solvent accessibility changes in this transiently phosphorylated state were probed by MALDI-TOF-detected amide hydrogen/deuterium exchange. No changes in solvent accessibility were seen in the regulatory domain upon phosphorylation of Asp56, but two regions in the catalytic domain (199-203 and 310-317) became more solvent accessible. These two regions flank the active site and contain domain-domain contact residues. Comparison with results from the isolated catalytic domain-containing C-terminal fragment of CheB (residues 147-349) showed that the increased solvent accessibility was less than would have occurred upon detachment of the regulatory domain. Thus, phosphorylation causes subtle changes in solvent accessibility at the interdomain interface of CheB.
Relation between patterns of intrinsic lateral connectivity, ocular dominance, and cytochrome oxidase-reactive regions in macaque monkey striate cortex.

To help understand the role of long-range, clustered lateral connections in the superficial layers of macaque striate cortex (area V1), we have examined the relationship of the patterns of intrinsic connections to cytochrome oxidase (CO) blobs, interblobs, and ocular dominance (OD) bands, using biocytin based neuroanatomical tracing, CO histochemistry, and optical imaging. Microinjections of biocytin in layer 3 resulted in an asymmetric field (average anisotropy of 1.8; maximum spread--3.7 mm) of labeled axon terminal clusters in layers 1-3, with the longer axis of the label spread oriented orthogonal to the rows of blobs and imaged OD stripes, parallel to the V1/V2 border. These labeled terminal patches (n = 186) from either blob or interblob injections (n = 20) revealed a 71% (132 out of 186) commitment of patches to the same compartment as the injection site; 11% (20 out of 186) to the opposite compartment, and 18% (34 out of 186) to borders of blob-interblob compartments, indicating that the connectivity pattern is not strictly blob to blob, or interblob to interblob (p < 0.005; chi(2)). In injections placed within single OD domains (n = 11), 54% of the resulting labeled terminal patches (43 out of 79) fell into the same OD territories as the injection sites, 28% (22 out of 79) into the opposite OD regions, and 18% (14 out of 79) on borders, showing some connectional bias toward same-eye compartments (p < 0.02; ANOVA). Individual injection cases, however, varied in the degree (50-100% for CO patterns, 22-100% for OD patterns) to which they showed same-compartment connectivity. These results reveal that while connectivity between similar compartments predominates (e.g., blob to blob, right eye column to right eye column), interactions do occur between functionally different regions.
Evidence for minimal pairs in Turkish Sign Language (TİD)

Abstract Recently, many studies have examined the phonological parameters in sign languages from various research perspectives, paying close attention in particular to manual parameters such as handshape, place of articulation, movement, and orientation of the hands. However, these studies have been conducted on only a few sign languages such as American and British Sign Languages, and have paid little attention to nonmanual features. In this study, we investigated yet another sign language, Turkish Sign Language (TİD), focusing on both manual and nonmanual features to examine "minimal pairs", a cornerstone concept of phonology. We applied Brentari's (2005) feature classification and Pfau and Quer's (2010) phonological (or lexical) nonmanual categorization. Our analysis showed that both phonological features and constraints on TİD sign formation have a phonological structure similar to other well-studied sign languages. The results indicate that not only are phonological features a necessary notion for the description of both manual and nonmanual parameters at the lexical level in TİD, but also that nonmanuals have to be considered an essential part of sign as a way of better understanding their phonological roles in sign language phonology.
Optimizing General-Purpose CPUs for Energy-Efficient Mobile Web Computing

Mobile applications are increasingly being built using web technologies as a common substrate to achieve portability and to improve developer productivity. Unfortunately, web applications often incur large performance overhead, directly affecting the user quality-of-service (QoS) experience. Traditional techniques in improving mobile processor performance have mostly been adopting desktop-like design techniques such as increasing single-core microarchitecture complexity and aggressively integrating more cores. However, such a desktop-oriented strategy is likely coming to an end due to the stringent energy and thermal constraints that mobile devices impose. Therefore, we must pivot away from traditional mobile processor design techniques in order to provide sustainable performance improvement while maintaining energy efficiency. In this article, we propose to combine hardware customization and specialization techniques to improve the performance and energy efficiency of mobile web applications. We first perform design-space exploration (DSE) and identify opportunities in customizing existing general-purpose mobile processors, that is, tuning microarchitecture parameters. The thorough DSE also lets us discover sources of energy inefficiency in customized general-purpose architectures. To mitigate these inefficiencies, we propose, synthesize, and evaluate two new domain-specific specializations, called the Style Resolution Unit and the Browser Engine Cache. Our optimizations boost performance and energy efficiency at the same time while maintaining general-purpose programmability. As emerging mobile workloads increasingly rely more on web technologies, the type of optimizations we propose will become important in the future and are likely to have a long-lasting and widespread impact.
Copper: Bringing Flexible Components to the .NET Framework

Component-oriented programming languages(COPLs) bridge the gap between architecture descriptionlanguages (ADLs) and general purpose programming languages. COPLs emphasize designing software systems out of reusablecomponents which are connected by communication ports. These ports facilitate the design of highly modular softwarearchitecture. The flexibility of a component-based system, however, is partly dependent on the variety of ports andconnections that are available. More port and connectionfeatures enable system architects to design more loosely coupledand reusable software components. This paper introduces aprototype language extension to C#, called Copper, which addscomponent-oriented programming features to the developer'srepertoire. Copper is based on the Mono C# compiler, andprovides convenient syntax for connecting incompatible ports, connecting ports to multiple senders, embedding ports statically, and connecting ports to non-component services. Copper'sbackward compatibility with C# permits existing C# code to beincrementally refactored into a component-oriented style.
Virtual point in time access

Continuous Data Protection or CDP is a method for capturing all changes occurring to a storage device, allowing fine granularity restore of objects from crash consistent images. In this paper we introduce a method for creating a virtual image of a block storage device, using a CDP journal log and an image of the device at one point in time. The creation of the disk image for any point in time is created on demand. The creation algorithm is very efficient and takes only a few minutes for multiple TeraBytes of changes. The algorithm for creating the image can be formalized as a map/reduce algorithm and can be parallelized easily over multiple machines to reduce the creation time. The creation on demand of the virtual image using journaling methods, minimizes the effect on the production volumes, allowing the use of CDPs for enterprise class applications.
All Fingers are not Equal: Intensity of References in Scientific Articles

Research accomplishment is usually measured by considering all citations with equal importance, thus ignoring the wide variety of purposes an article is being cited for. Here, we posit that measuring the intensity of a reference is crucial not only to perceive better understanding of research endeavor, but also to improve the quality of citation-based applications. To this end, we collect a rich annotated dataset with references labeled by the intensity, and propose a novel graph-based semi-supervised model, GraLap to label the intensity of references. Experiments with AAN datasets show a significant improvement compared to the baselines to achieve the true labels of the references (46% better correlation). Finally, we provide four applications to demonstrate how the knowledge of reference intensity leads to design better real-world applications.
Cromolyn Sodium Decreases the Pulmonary Vascular Response to Alveolar Hypoxia in Lambs

ABSTRACT. We investigated the effect of cromolyn sodium, a mast cell stabilizing agent, on the pulmonary vascular response to alveolar hypoxia in six chronically instrumented lambs aged 9 to 11 days. Each lamb was instrumented on day 6 or 7 for measurements of systemic arterial, pulmonary arterial and left atrial pressures, and pulmonary blood flow. The animals were allowed to recover from surgery at least 3 days before they were studied. Each animal was studied twice, once with a cromolyn sodium infusion and once with a normal saline infusion (placebo). These paired experiments were separated by 24 h. Physiologic measurements were made during a 1-min predose control period, after an 8-min drug or placebo infusion, and after a 15-min period of alveolar hypoxia. Cromolyn sodium infusion alone did not affect baseline cardiovascular variables. Alveolar hypoxia following placebo infusion produced an increase in pulmonary arterial pressure and pulmonary vascular resistance; these responses were blocked in the animals given cromolyn sodium prior to induction of hypoxia. These results show that cromolyn sodium blocks the pulmonary vascular response to hypoxia and provide indirect evidence that mast cell degranulation, with subsequent release of vasoactive agents, mediates the pulmonary vascular response to hypoxia in newborn lambs.
An electromyographic analysis of reflex deglutition.

DEGLUTITION is a reflex coordination readily accessible and conveniently exact, yet far surpassing the integrative qualities of simpler reflex action. In a manner yet unknown, motoneurons scattered from C3 to the mesencephalon are reproducibly controlled in an intricate pattern of excitation and inhibition specific to this synergy. This paper presents an electromyographic definition of this performance and in so doing more closely specifies the necessary characteristics of its coordinative mechanism.
Bézout Identities With Inequality Constraints

We dedicate this paper to Ambikeshwar Sharma with esteem, admiration and gratitude for lighting our way. Abstract. This paper examines the set B(P) = fQ : P Q = 1 ; Q 2 R m g where P 2 R m is unimodular and R is either the algebra P R of algebraic polynomials which are real{valued on the cube I d or the algebra L R of Laurent polynomials which are real{valued on the torus T d : We sharpen previous results for the case m = 2; d = 1 by showing that if P is non-negative, then there exists a positive Q 2 B(P) whose length is bounded by a function of the length of P and the separation between the zeros of P: In the general case we employ the Quillen-Suslin theorem, the Swan theorem, the Weierstrass approximation theorem and the Michael selection theorem to prove a result about the existence of solutions to the B ezout identity with inequality constraints.
A study of serum interleukin-12 in a sample of autistic children in Egypt

Introduction Autistic spectrum disorders (ASDs) prevalence varies widely by sex and the racial/ethnic group. The male-to-female ratio ranged from 3 to 4 : 1. Some consider ASD to be an autoimmune disorder, in which the autoimmune response to the developing brain myelin may impair anatomical development of neural pathways in autistic children; this affects the speed of impulse transmission. Interleukin-12 (IL-12) is an interleukin that is naturally produced by dendritic cells and macrophages in response to antigenic stimulation; it plays an important role in the activities of natural killer cells and T lymphocytes involved in the immune system. Aim of the work The present study was conducted to compare the level of serum IL-12 between children with autistic disorder (AD) and healthy control children, and also to study the relation of serum IL-12 with the severity of autistic symptoms. Participants and methods A cross-sectional study was conducted on two groups; group I included 20 patients with AD and group II included 20 normal children matched for age and sex, recruited from the Child and Adolescent Outpatients Clinic at Al Hadra University Hospital. All children were subjected to a complete psychiatric history, physical and neurological examination, psychometric assessment by Childhood Autistic Rating Scale, and estimation of serum IL-12 using the enzyme-linked immunosorbent assay method. Results The mean serum level of IL-12 was significantly higher in AD children than in controls and was related to a younger age, male sex, a positive family history and ante/natal/postnatal history, nondevelopment of spoken language, the presence of comorbidities, and higher Childhood Autistic Rating Scale mean scores. Conclusion The study pointed out an immunological impairment in the form of an elevated serum level of IL-12 in autistic children and its positive relation to autistic symptom severity. This supports the immunological etiology of ASD.
T-cell signalling and immune system disorders

T-cell receptor (TCR) engagement initiates intracellular signalling cascades that lead to T-cell proliferation, cytokine production and differentiation into effector cells. These cascades comprise an array of protein-tyrosine kinases, phosphatases, GTP-binding proteins and adaptor proteins that regulate generic and specialised functions. The integration of these signals is essential for the normal development, homeostasis and function of T cells. Defects in a single mediator can produce T cells that are unable to participate fully in an immune response and/or that mount an inappropriate response, which leads to immunodeficiency, autoimmunity or leukaemia/lymphomas. This review highlights some of the key players in T-cell signalling and their involvement in the development of various clinical disease states. Some of these immune-specific signalling proteins are attractive potential targets in the development of therapies to augment T-cell responses to antigen or tumours, and to treat immune cell disorders.
Air pollution and emergency room visits for asthma in Santa Clara County, California.

During the winters of 1986-1987 through 1991-1992, rainfall throughout much of Northern California was subnormal, resulting in intermittent accumulation of air pollution, much of which was attributable to residential wood combustion (RWC). This investigation examined whether there was a relationship between ambient air pollution in Santa Clara County, California and emergency room visits for asthma during the winters of 1988-1989 through 1991-1992. Emergency room (ER) records from three acute-care hospitals were abstracted to compile daily visits for asthma and a control diagnosis (gastroenteritis) for 3-month periods during each winter. Air monitoring data included daily coefficient of haze (COH) and every-other-day particulate matter with aerodynamic diameter equal to or less than 10 microns (PM10, 24-hr average), as well as hourly nitrogen dioxide and ozone concentrations. Daily COH measurements were used to predict values for missing days of PM10 to develop a complete PM10 time series. Daily data were also obtained for temperature, precipitation, and relative humidity. In time-series analyses using Poisson regression, consistent relationships were found between ER visits for asthma and PM10. Same-day nitrogen dioxide concentrations were also associated with asthma ER visits, while ozone was not. Because there was a significant interaction between PM10 and minimum temperature in this data set, estimates of relative risks (RRs) for PM10-associated asthma ER visits were temperature-dependent. A 60 micrograms/m3 change in PM10 (2-day lag) corresponded to RRs of 1.43 (95% CI = 1.18-1.69) at 20 degrees F, representing the low end of the temperature distribution, 1.27 (95% CI = 1.13-1.42) at 30 degrees F, and 1.11 (95% CI = 1.03-1.19) at 41 degrees F, the mean of the observed minimum temperature. ER visits for gastroenteritis were not significantly associated with any pollutant variable. Several sensitivity analyses, including the use of robust regressions and of nonparametric methods for fitting time trends and temperature effects in the data, supported these findings. These results demonstrate an association between ambient wintertime PM10 and exacerbations of asthma in an area where one of the principal sources of PM10 is RWC. ImagesFigure 1.
Base Pairing Interaction between 5′- and 3′-UTRs Controls icaR mRNA Translation in Staphylococcus aureus

The presence of regulatory sequences in the 3′ untranslated region (3′-UTR) of eukaryotic mRNAs controlling RNA stability and translation efficiency is widely recognized. In contrast, the relevance of 3′-UTRs in bacterial mRNA functionality has been disregarded. Here, we report evidences showing that around one-third of the mapped mRNAs of the major human pathogen Staphylococcus aureus carry 3′-UTRs longer than 100-nt and thus, potential regulatory functions. We selected the long 3′-UTR of icaR, which codes for the repressor of the main exopolysaccharidic compound of the S. aureus biofilm matrix, to evaluate the role that 3′-UTRs may play in controlling mRNA expression. We showed that base pairing between the 3′-UTR and the Shine-Dalgarno (SD) region of icaR mRNA interferes with the translation initiation complex and generates a double-stranded substrate for RNase III. Deletion or substitution of the motif (UCCCCUG) within icaR 3′-UTR was sufficient to abolish this interaction and resulted in the accumulation of IcaR repressor and inhibition of biofilm development. Our findings provide a singular example of a new potential post-transcriptional regulatory mechanism to modulate bacterial gene expression through the interaction of a 3′-UTR with the 5′-UTR of the same mRNA.
Placental transfer of aldosterone in the sheep.

To determine the percentage of the maternal secretion of aldosterone which crosses the placenta the blood clearance rate (BCR) of aldosterone was measured in pregnant sheep and in chronically cannulated fetuses by the constant infusion of [3H]aldosterone alternately into the maternal and fetal compartments. When equilibrium had been reached the concentration of [3H]aldosterone was measured in both maternal and fetal compartments. Aldosterone BCR in eight pregnant ewes was 98 +/- 5 (S.E.M.) litres/h which was not significantly different from that of ten non-pregnant ewes at 95 +/- litres/h. The BCR of aldoterone in seven fetuses was 24 +/- litres/h. A small percentage (4.4 +/- 0.3; n = 7) of the maternal production rate was transferred to the fetus, whilst 29 +/- 4% (n = 8) of the fetal production rate was transferred to the maternal compartment. Whjen aldosterone was measured in maternal and fetal blood samples collected simultaneously from sodium-replete sheep more than 80% of the aldosterone in fetal blood was of fetal origin if the actual fetal concentration of aldosterone was greater than 1.5 ng/dl.
Minimum variance distortionless response spectral estimation

In this article, we concentrate on spectral estimation techniques that are useful in extracting the features to be used by automatic speech recognition (ASR) system. As an aid to understanding the spectral estimation process for speech signals, we adopt the source filter model of speech production as presented in X. Huang et al. (2001), wherein speech is divided into two broad classes: voiced and unvoiced. Voiced speech is quasi-periodic, consisting of a fundamental frequency corresponding to the pitch of a speaker, as well as its harmonics. Unvoiced speech is stochastic in nature and is best modeled as white noise convolved with an infinite impulse response filter.