Miracle-dz/UniFAR-FTUs huggingface dataset:
Novel Role for the Potent Endogenous Inotrope Apelin in Human Cardiac Dysfunction

Background—Apelin is among the most potent stimulators of cardiac contractility known. However, no physiological or pathological role for apelin–angiotensin receptor-like 1 (APJ) signaling has ever been described. Methods and Results—We performed transcriptional profiling using a spotted cDNA microarray with 12 814 unique clones on paired samples of left ventricle obtained before and after placement of a left ventricular assist device in 11 patients. The significance analysis of microarrays and a novel rank consistency score designed to exploit the paired structure of the data confirmed that natriuretic peptides were among the most significantly downregulated genes after offloading. The most significantly upregulated gene was the G-protein–coupled receptor APJ, the specific receptor for apelin. We demonstrate here using immunoassay and immunohistochemical techniques that apelin is localized primarily in the endothelium of the coronary arteries and is found at a higher concentration in cardiac tissue after mechanical offloading. These findings imply an important paracrine signaling pathway in the heart. We additionally extend the clinical significance of this work by reporting for the first time circulating human apelin levels and demonstrating increases in the plasma level of apelin in patients with left ventricular dysfunction. Conclusions—The apelin-APJ signaling pathway emerges as an important novel mediator of cardiovascular control.
Cardiovascular and noncardiovascular mortality among patients starting dialysis.

CONTEXT Cardiovascular mortality is considered the main cause of death in patients receiving dialysis and is 10 to 20 times higher in such patients than in the general population. OBJECTIVE To evaluate if high overall mortality in patients starting dialysis is a consequence of increased cardiovascular mortality risk only or whether noncardiovascular mortality is equally increased. DESIGN, SETTING, AND PATIENTS Using data from between January 1, 1994, and January 1, 2007, age-stratified mortality in a European cohort of adults starting dialysis and receiving follow-up for a mean of 1.8 (SD, 1.1) years (European Renal Association-European Dialysis and Transplant Association [ERA-EDTA] Registry [N = 123,407]) was compared with the European general population (Eurostat). MAIN OUTCOME MEASURES Cause of death was recorded by ERA-EDTA codes in patients and matching International Statistical Classification of Diseases, 10th Revision codes in the general population. Standardized cardiovascular and noncardiovascular mortality rates, their ratio, difference, and relative excess of cardiovascular over noncardiovascular mortality were calculated. RESULTS Overall all-cause mortality rates in patients and the general population were 192 per 1000 person-years (95% confidence interval [CI], 190-193) and 12.055 per 1000 person-years (95% CI, 12.05-12.06), respectively. Cause of death was known for 90% of the patients and 99% of the general population. In patients, 16,654 deaths (39%) were cardiovascular and 21,654 (51%) were noncardiovascular. In the general population, 7,041,747 deaths (40%) were cardiovascular and 10,183,322 (58%) were noncardiovascular. Cardiovascular and noncardiovascular mortality rates in patients were respectively 38.1 per 1000 person-years (95% CI, 37.2-39.0) and 50.1 per 1000 person-years (95% CI, 48.9-51.2) higher than in the general population. On a relative scale, standardized cardiovascular and noncardiovascular mortality were respectively 8.8 (95% CI, 8.6-9.0) and 8.1 (95% CI, 7.9-8.3) times higher than in the general population. The ratio of these rates, ie, relative excess of cardiovascular over noncardiovascular mortality in patients starting dialysis compared with the general population, was 1.09 (95% CI, 1.06-1.12). Relative excess in a sensitivity analysis in which unknown/missing causes of death were regarded either as noncardiovascular or cardiovascular varied between 0.90 (95% CI, 0.88-0.93) and 1.39 (95% CI, 1.35-1.43). CONCLUSION Patients starting dialysis have a generally increased risk of death that is not specifically caused by excess cardiovascular mortality.
Demonstration of a forward iterative method to reconstruct brachytherapy seed configurations from x-ray projections

By monitoring brachytherapy seed placement and determining the actual configuration of the seeds in vivo, one can optimize the treatment plan during the process of implantation. Two or more radiographic images from different viewpoints can in principle allow one to reconstruct the configuration of implanted seeds uniquely. However, the reconstruction problem is complicated by several factors: (1) the seeds can overlap and cluster in the images; (2) the images can have distortion that varies with viewpoint when a C-arm fluoroscope is used; (3) there can be uncertainty in the imaging viewpoints; (4) the angular separation of the imaging viewpoints can be small owing to physical space constraints; (5) there can be inconsistency in the number of seeds detected in the images; and (6) the patient can move while being imaged. We propose and conceptually demonstrate a novel reconstruction method that handles all of these complications and uncertainties in a unified process. The method represents the three-dimensional seed and camera configurations as parametrized models that are adjusted iteratively to conform to the observed radiographic images. The morphed model seed configuration that best reproduces the appearance of the seeds in the radiographs is the best estimate of the actual seed configuration. All of the information needed to establish both the seed configuration and the camera model is derived from the seed images without resort to external calibration fixtures. Furthermore, by comparing overall image content rather than individual seed coordinates, the process avoids the need to establish correspondence between seed identities in the several images. The method has been shown to work robustly in simulation tests that simultaneously allow for unknown individual seed positions, uncertainties in the imaging viewpoints and variable image distortion.
Understanding the Molecular Mechanism of Interventions in Treating Rheumatoid Arthritis Patients with Corresponding Traditional Chinese Medicine Patterns Based on Bioinformatics Approach

Better effectiveness would be achieved when interventions are used in treating patients with a specific traditional Chinese medicine (TCM) pattern. In this paper, the effectiveness in treating rheumatoid arthritis (RA) patients in a randomized clinical trial as reanalyzed after the patients were classified into different TCM patterns and the underlying mechanism of how the TCM pattern influences the clinical effectiveness of interventions (TCM and biomedicine therapy) was explored. The pharmacological networks of interventions were builtup with protein and protein interaction analyses based on all the related targeted proteins obtained from PubChem. The underlying mechanism was explored by merging the pharmacological networks with the molecular networks of TCM cold and hot patterns in RA. The results show that the TCM therapy is better in treating the RA patients with TCM hot pattern, and the biomedical therapy is better in the RA patients with cold pattern. The pharmacological network of TCM intervention is merged well with the molecular network of TCM hot pattern, and the pharmacological network of biomedical therapy is merged well with the network of cold pattern. The finding indicates that molecular network analysis could give insight into the full understanding of the underlying mechanism of how TCM pattern impacts the efficacy.
A hardware/software partitioning algorithm for pipelined instruction set processor

This paper proposes a new method to design an optimal instruction set for pipelined ASIP development using a formal HW/SW codesign methodology. The codesign task addressed in this paper is to find a set of HW implemented operations to achieve the highest performance of a pipelined ASIP under a given gate count and power consumption constraint. The method enables to estimate the performance and pipeline hazards of the designed ASIP very accurately. The experimental results show that the proposed method is effective and quite efficient.
Pretransplantation [18‐F]fluorodeoxyglucose positron emission tomography scan predicts outcome in patients with recurrent Hodgkin lymphoma or aggressive non‐Hodgkin lymphoma undergoing reduced‐intensity conditioning followed by allogeneic stem cell transplantation

The use of positron emission tomography (PET) scanning in Hodgkin lymphoma (HL) and aggressive non‐Hodgkin lymphoma (HG‐NHL) has recognized prognostic value in patients who are receiving chemotherapy or undergoing autologous stem cell transplantation (SCT). In contrast, the role of PET before reduced‐intensity conditioning (RIC) and followed by allogeneic SCT has not been investigated to date.
Memristors-based Ternary Content Addressable Memory (mTCAM)

A memristors-based Ternary Content Addressable Memory (mTCAM) is presented. A unit mTCAM cell consists of 5T2R, five transistors and two memristors to store the ternary information, having higher storage density than conventional CMOS TCAMs together with the memristors' unique non-volatility. In the write mode, each memristor in the cell is programmed individually such that high impedance is always present between searchlines to reduce the direct current. A two-step write scheme is proposed to reduce the write voltage compliance, and the search voltage used to drive the search content was chosen to optimize the sensing margin. Simulation results for a 2×4 mTCAM array demonstrate the functionality and feasibility of the proposed mTCAM structure, in both write and search modes.
Determinants of plasma fibrinogen: relation to body weight, waist-to-hip ratio, smoking, alcohol, age, and sex. Results from the second MONICA Augsburg survey 1989-1990.

In the second World Health Organization MONItoring Trends and Determinants in CArdiovascular Disease (MONICA) Augsburg survey in 1989-1990 (n = 4,940), the association between nephelometric plasma fibrinogen level and lifestyle-related potential determinants was assessed in 4,434 subjects aged 25-74 years (89.8% of participants). Irrespective of pregnancy and the use of oral contraceptives, crude fibrinogen values were consistently higher in women than in men of all ages (age-standardized difference, 12.2 mg/dl; 95% confidence interval, 7.0-17.4 mg/dl). Fibrinogen concentrations were positively correlated (p less than or equal to 0.0001) with age, body mass index, and waist-to-hip ratio in both sexes and with cigarette smoking in men and were negatively correlated with alcohol consumption in both sexes. In multiple linear regression analyses using categorized determinants as independent variables, a strongly J-shaped relation for body mass index in women and a linear association for waist-to-hip ratio in men were revealed. Smoking had a dose-dependent effect on fibrinogen concentration in men but a lesser effect in women. For alcohol consumption a U-shaped association was found, particularly in men. The curvilinear relations were confirmed in multiple polynomial regression models using continuous determinant variables. The potential epidemiological impact of a determinant was assessed by calculating differences in adjusted fibrinogen concentrations associated with the 10th and 90th percentile values of the determinant distributions actually observed among the study participants. This impact on the population fibrinogen level was most pronounced for age in both sexes, followed by body mass index, cigarette smoking, and alcohol consumption in women and by smoking, waist-to-hip ratio, and alcohol consumption in men. (ABSTRACT TRUNCATED AT 250 WORDS)
Measurements of the wall shear stress distribution in the outflow tract of an embryonic chicken heart

In order to study the role of blood–tissue interaction in the developing chicken embryo heart, detailed information about the haemodynamic forces is needed. In this study, we present the first in vivo measurements of the three-dimensional distribution of wall shear stress (WSS) in the outflow tract (OFT) of an embryonic chicken heart. The data are obtained in a two-step process: first, the three-dimensional flow fields are measured during the cardiac cycle using scanning microscopic particle image velocimetry; second, the location of the wall and the WSS are determined by post-processing flow velocity data (finding velocity gradients at locations where the flow approaches zero). The results are a three-dimensional reconstruction of the geometry, with a spatial resolution of 15–20 µm, and provides detailed information about the WSS in the OFT. The most significant error is the location of the wall, which results in an estimate of the uncertainty in the WSS values of 20 per cent.
A Constraint-Based Control Architecture for Acting and Reasoning in Autonomous Robots

In this paper we will address several architectural decisions in defining a software control architecture for mobile robots. Our system is a collection of control primitives that enables the development of simulations or control algorithms for autonomous agents. Its computational capabilities are determined by an object-oriented constraint-based architecture. We discuss how high level knowledge, skills, goal-driven and reactive behavior are integrated within such an architecture. Our goal is to design a framework that enables the merging of classic and reactive implementation ideas. We will show, that each such type of control can be implemented in our system. The issues of task decomposition and granularity are given special attention, as they lie at the basis of our architecture. We discuss two learning methods supported by our system. The first is based on environment exploration, while the second copes with skill acquisition. Our robot, CYCLOPS , is a LEGO mini-robot based on the 6.270 MIT kit to be used in a package delivery application.
Inertia Estimation of the GB Power System Using Synchrophasor Measurements

A novel procedure for estimating the total inertia of the Great Britain (GB) power system is presented. Following an instantaneous in-feed loss, regional variations in the estimate of inertia are obtained from measured frequency transients using installed synchronised phasor measurement units (PMUs). A method is proposed to first detect a suitable event for analysis, and then filter the measured transients in order to obtain a reliable estimate of inertia for a given region of the GB network. The total inertia for the whole system is then calculated as a summation, with an estimate also provided as to the contribution to inertia from residual sources, namely synchronously connected demand and embedded generation. The approach is first demonstrated on the full dynamic model of the GB transmission system, before results are presented from analyzing the impact of a number of instantaneous transmission in-feed loss events using phase-angle data provided by PMUs from the GB transmission network and also devices installed at the domestic supply at 4 GB universities.
On the (im)possibility of obfuscating programs

Informally, an <i>obfuscator</i> <i>O</i> is an (efficient, probabilistic) “compiler” that takes as input a program (or circuit) <i>P</i> and produces a new program <i>O</i>(<i>P</i>) that has the same functionality as <i>P</i> yet is “unintelligible” in some sense. Obfuscators, if they exist, would have a wide variety of cryptographic and complexity-theoretic applications, ranging from software protection to homomorphic encryption to complexity-theoretic analogues of Rice's theorem. Most of these applications are based on an interpretation of the “unintelligibility” condition in obfuscation as meaning that <i>O</i>(<i>P</i>) is a “virtual black box,” in the sense that anything one can efficiently compute given <i>O</i>(<i>P</i>), one could also efficiently compute given oracle access to <i>P</i>. In this work, we initiate a theoretical investigation of obfuscation. Our main result is that, even under very weak formalizations of the above intuition, obfuscation is impossible. We prove this by constructing a family of efficient programs <i>P</i> that are <i>unobfuscatable</i> in the sense that (a) given <i>any</i> efficient program <i>P</i>' that computes the same function as a program <i>P</i> ∈ <i>p</i>, the “source code” <i>P</i> can be efficiently reconstructed, yet (b) given <i>oracle access</i> to a (randomly selected) program <i>P</i> ∈ <i>p</i>, no efficient algorithm can reconstruct <i>P</i> (or even distinguish a certain bit in the code from random) except with negligible probability. We extend our impossibility result in a number of ways, including even obfuscators that (a) are not necessarily computable in polynomial time, (b) only approximately preserve the functionality, and (c) only need to work for very restricted models of computation (<b>TC<sup>0</sup></b>). We also rule out several potential applications of obfuscators, by constructing “unobfuscatable” signature schemes, encryption schemes, and pseudorandom function families.
Sweet elements of Siraitia grosvenori inhibit oxidative modification of low-density lipoprotein.

This study examined the ability of sweet elements extracted from Siraitia grosvenori (SG) to inhibit the oxidation of LDL. We monitored the formation of conjugated diene during copper-mediated LDL oxidation in the presence or absence of sweet elements of whole extract of SG (SG extract) or cucurbitane glycosides (CGs) purified from SG extract as sweet elements. CGs consist of Mogroside IV (Mog.IV), Mogroside V (Mog.V), 11-Oxo-mogroside V (11-Oxo-mog.V), and Siamenoside I (Sia.I). In addition, the effect of these elements on human umbilical vein endothelial cell (HUVEC)- mediated LDL oxidation was tested by measuring production of lipid peroxides. SG extract inhibited copper-mediated LDL oxidation in a dose-dependent fashion, but neither glucose nor erythritol suppressed the oxidation. Among CGs, 11-Oxo-mog.V significantly inhibited LDL oxidation, and prolongation of the lag time during LDL oxidation by 11-Oxo-mog.V was dose-dependent. The lag time (119.7 +/- 8.9 min) in the presence of 200 microM 11-Oxo-mog.V was significantly longer than that (76.8 +/- 5.5 min) of control (p < 0.01). In addition, SG extract and 11-Oxo-mog.V inhibited HUVEC-mediated LDL oxidation in a dose-dependent manner. These results demonstrate that SG extract can inhibit LDL oxidation and that 11-Oxo-mog.V, a sweet element of SG extract, provides the anti-oxidative property of SG which might reduce the atherogenic potential of LDL.
Digital Nudging: Altering User Behavior in Digital Environments

Individuals make increasingly more decisions on screens, such as those on websites or mobile apps. However, the nature of screens and the vast amount of information available online make individuals particularly prone to deficient decisions. Digital nudging is an approach based on insights from behavioral economics that applies user interface (UI) design elements to affect the choices of users in digital environments. UI design elements include graphic design, specific content, wording or small features. To date, little is known about the psychological mechanisms that underlie digital nudging. To address this research gap, we conducted a systematic literature review and provide a comprehensive overview of relevant psychological effects and exemplary nudges in the physical and digital sphere. These insights serve as a valuable basis for researchers and practitioners that aim to study or design information systems and interventions that assist user decision making on screens.
Equal-Sized Cells Mean Equal-Sized Packets in Tor?

Tor is a well-known low-latency anonymous communication system. To prevent the traffic analysis attack, Tor packs application data into equal-sized cells. However, we found that equal-sized cells at the application layer do not necessarily produce equal-sized packets at the network layer. Therefore, we introduced a packet size based attack that compromises Tor's communication anonymity with no need of controlling Tor routers. An attacker can manipulate size of packets between a web site and an exit onion router and embeds a signal into the target traffic. An accomplice at the user side can sniff the traffic and recognize this signal. To cope with the signal distortion incurred by Tor and Internet, we developed an effective signal recovery mechanism. Our real-world experiments validate the effectiveness of our attack against Tor. Our work demonstrates the need for re-considering the issue of padding anonymous communication data into equal size.
User-centered security

We introduce the term user-centered security to refer to security models, mechanisms, systems, and software that have usability as a primary motivation or goal. We discuss the history of usable secure systems, citing both past problems and present studies. We develop three categories for work in user-friendly security: applying usability testing and techniques to secure systems, developing security models and mechanisms for user-friendly systems, and considering user needs as a primary design goal at the start of secure system development. We discuss our work on user-centered authorization, which started with a rules-based authorization engine (MAP) and will continue with Adage. We outline the lessons we have learned to date and how they apply to our future work. We evaluate the pros and cons of this effort, as a precursor to further work in this area, and include a brief description of our current work in user-centered authorization. As our conclusion points out, we hope to see more work in user-centered security in the future; work that enables users to choose and use the protection they want, that matches their intuitions about security and privacy, and that supports the policies that teams and organizations need and use to get their work done. II. USABILITY IN SECURE SOFTWARE Keywordsuser-centered, security, authorization
Correlation of primary middle and distal esophageal cancers motion with surrounding tissues using four-dimensional computed tomography

Purpose To investigate the correlation of gross tumor volume (GTV) motion with the structure of interest (SOI) motion and volume variation for middle and distal esophageal cancers using four-dimensional computed tomography (4DCT). Patients and methods Thirty-three patients with middle or distal esophageal carcinoma underwent 4DCT simulation scan during free breathing. All image sets were registered with 0% phase, and the GTV, apex of diaphragm, lung, and heart were delineated on each phase of the 4DCT data. The position of GTV and SOI was identified in all 4DCT phases, and the volume of lung and heart was also achieved. The phase relationship between the GTV and SOI was estimated through Pearson’s correlation test. Results The mean peak-to-peak displacement of all primary tumors in the lateral (LR), anteroposterior (AP), and superoinferior (SI) directions was 0.13 cm, 0.20 cm, and 0.30 cm, respectively. The SI peak-to-peak motion of the GTV was defined as the greatest magnitude of motion. The displacement of GTV correlated well with heart in three dimensions and significantly associated with bilateral lung in LR and SI directions. A significant correlation was found between the GTV and apex of the diaphragm in SI direction (rleft=0.918 and rright=0.928). A significant inverse correlation was found between GTV motion and varying lung volume, but the correlation was not significant with heart (rLR=−0.530, rAP=−0.531, and rSI=−0.588) during respiratory cycle. Conclusion For middle and distal esophageal cancers, GTV should expand asymmetric internal margins. The primary tumor motion has quite good correlation with diaphragm, heart, and lung.