Miracle-dz/UniFAR-FTUs huggingface dataset:
Primary electrical disorder or primary cardiomyopathy? A case with a unique association of noncompaction cardiomyopathy and cathecolaminergic polymorphic ventricular tachycardia caused by ryanodine receptor mutation.

Noncompaction cardiomyopathy (NCCM) is a rare primary cardiomyopathy caused by an arrest in myocardial morphogenesis.1 The clinical manifestations are highly variable from asymptomatic to severe heart failure, arrhythmias, sudden cardiac death, or systemic thrombo-embolic events. Association of NCCM and electric disorders has been reported as rare case reports with WPW syndrome and Brugada syndrome,2 But to the best of our knowledge, an association with catecholaminergic polymorphic ventricular tachycardia (CPVT) and NCCM has never been reported. The aim of the case report is to present unique features of both NCCM and gene mutation–proven CPVT in 1 patient, raising new questions. A 39-year-old woman was referred with frequent palpitations, exercise-induced dyspnea, fatigue, and tendency to faint. Her medical and family history revealed no cardiac disease. ECG demonstrated sinus bradycardia, 50 beats per minute, and mild inferolateral repolarization abnormalities. Echocardiography and MRI showed normal left ventricular function (ejection …
Identification of Nonlinear Dynamic Systems via the Neuro-Fuzzy Computing and Genetic Algorithms

In this paper, an effective method for selecting significant input variables in building ANFIS (Adaptive Neuro-Fuzzy Inference System) for nonlinear system modeling is proposed. Dominant inputs in a nonlinear system identification process are extracted by evaluating the performance index and they are applied to ANFIS. The availability of our proposed model is verified with the Box and Jenkins gas furnace data. The comparisons with other methods are also given in this paper to show our proposed method is superior to other models.
Comparative Analysis Of Encryption Algorithms For Data Communication

Information Security has become an important issue in data communication. Encryption has come up as a solution, and plays an important role in information security system. This security mechanism uses some algorithms to scramble data into unreadable text which can be only being decoded or decrypted by party those possesses the associated key. These algorithms consume a significant amount of computing resources such as CPU time, memory and battery power and computation time. This paper performs comparative analysis of three algorithm; DES, AES and RSA considering certain parameters such as computation time, memory usages and output byte. A cryptographic tool is used for conducting experiments. Experiments results are given to analyses the effectiveness of each algorithm
A dataflow representation for defining behaviours within virtual environments

Construction of immersive virtual environments usually takes place outside the virtual environment in configuration files or application code. The system presented in this paper allows interaction with and behaviours of objects to be defined whilst immersed within the system by manipulating a dataflow representation of the dialogue occuring between the input devices and virtual objects. A concrete example is presented that illustrates the flexibility and customization opportunities that this approach provides.
Predicting the intention to cyberbully and cyberbullying behaviour among the undergraduate students at the International Islamic University Malaysia

Abstract: This study analyses the contributing factors to cyberbullying behaviour; 397 Muslim undergraduate students participated in the study and it has yielded some interesting results. Underpinned by the theory of planned behaviour, this study found some support for the theory. Specifically, perceived social pressure (subjective norms) has been identified as the most important predictor, followed by attitudes towards cyberbullying. However, perceived behavioural control was not significantly related to the toxic behaviour. Overall, these results indicate the need to address the anti-social behaviour by related-parties and preventive measures need to be taken in order to promote pro-social behaviours in the online environment.
LHON: Mitochondrial Mutations and More

Leber’s hereditary optic neuropathy (LHON) is a mitochondrial disorder leading to severe visual impairment or even blindness by death of retinal ganglion cells (RGCs). The primary cause of the disease is usually a mutation of the mitochondrial genome (mtDNA) causing a single amino acid exchange in one of the mtDNA-encoded subunits of NADH:ubiquinone oxidoreductase, the first complex of the electron transport chain. It was thus obvious to accuse neuronal energy depletion as the most probable mediator of neuronal death. The group of Valerio Carelli and other authors have nicely shown that energy depletion shapes the cell fate in a LHON cybrid cell model. However, the cybrids used were osteosarcoma cells, which do not fully model neuronal energy metabolism. Although complex I mutations may cause oxidative stress, a potential pathogenetic role of the latter was less taken into focus. The hypothesis of bioenergetic failure does not provide a simple explanation for the relatively late disease onset and for the incomplete penetrance, which differs remarkably between genders. It is assumed that other genetic and environmental factors are needed in addition to the ‘primary LHON mutations’ to elicit RGC death. Relevant nuclear modifier genes have not been identified so far. The review discusses the unresolved problems of a pathogenetic hypothesis based on ATP decline and/or ROS-induced apoptosis in RGCs.
The effects of vitamin D on skeletal muscle strength, muscle mass, and muscle power: a systematic review and meta-analysis of randomized controlled trials.

CONTEXT There is growing evidence that vitamin D plays a role on several tissues including skeletal muscle. OBJECTIVE The aim was to summarize with a meta-analysis, the effects of vitamin D supplementation on muscle function. DATA SOURCES A systematic research of randomized controlled trials, performed between 1966 and January 2014 has been conducted on Medline, Cochrane Database of Systematics Reviews, Cochrane Central Register of Controlled and completed by a manual review of the literature and congressional abstracts. STUDY SELECTION All forms and doses of vitamin D supplementation, with or without calcium supplementation, compared with placebo or control were included. Out of the 225 potentially relevant articles, 30 randomized controlled trials involving 5615 individuals (mean age: 61.1 years) met the inclusion criteria. DATA EXTRACTION Data were extracted by two independent reviewers. DATA SYNTHESIS Results revealed a small but significant positive effect of vitamin D supplementation on global muscle strength with a standardized mean difference (SMD) of 0.17 (P = .02). No significant effect was found on muscle mass (SMD 0.058; P = .52) or muscle power (SMD 0.057; P = .657). Results on muscle strength were significantly more important with people who presented a 25-hydroxyvitamin D level <30 nmol/L. Supplementation seems also more effective on people aged 65 years or older compared to younger subjects (SMD 0.25; 95% CI 0.01 to 0.48 vs SMD 0.03; 95% CI -0.08 to 0.14). CONCLUSIONS Vitamin D supplementation has a small positive impact on muscle strength, but additional studies are needed to define optimal treatment modalities, including dose, mode of administration, and duration.
Sexual Violence Victimisation and Subsequent Problematic Alcohol Use: Examining the Self-Medication Hypothesis

Findings from in-depth interviews conducted as part of a larger study that examined the interrelationship between male-perpetrated intimate partner violence, mental health problems, and alcohol/other drug use are presented. A subset of 15 adult women who were part of a larger study (N = 227) were asked about their experiences of sexual violence by an intimate partner, and their motivations to use alcohol in the context of chronic victimisation. Results suggested women use alcohol as a deliberate stress response to cope with anxiety and fear. Furthermore, participants reported to use alcohol as a form of gaining and/or maintaining control. Additional unsympathetic treatment by professionals was reported to exacerbate perceptions of helplessness and readiness to utilise alcohol as coping mechanism. The study concluded that women subjected to sexual violence by an intimate partner use alcohol for selfmedication purposes. Positive and negative reinforcement effects increase the probability of ongoing self-medicating behaviours. Recommendations include addressing the needs and fears of women using an empowerment approach. An improvement of inter-professional collaboration efforts may result in removal of barriers victimised women experience accessing support services.
Fatty acids and the metabolic syndrome

The metabolic syndrome is a very common condition, characterised by insulin resistance, dyslipidaemia, abdominal obesity and hypertension, that is associated with a high risk of type 2 diabetes mellitus (T2DM) and CVD. Obesity is a key aetiological factor in the development of the metabolic syndrome. In light of the increasing prevalence of obesity, there is a high requirement to reduce the impact of the adverse health effects associated with the metabolic syndrome. The aetiological role of nutrient-derived metabolic stressors, in particular fatty acids, in the development of obesity and the metabolic syndrome is explored. Also, the evidence that pro-inflammatory stressors may predispose to obesity-induced insulin resistance is reviewed. The present paper explores the concept that reducing the impact of metabolic and inflammatory stressors may reduce the adverse health effects of obesity and slow the progression towards the metabolic syndrome and T2DM. Evidence from human dietary intervention studies that have investigated the potential therapeutic effects of dietary fatty acid modification is explored. The present review highlights the requirement to take account of genetic background, within the context of nutrient regulation of gene expression and individual responsiveness to dietary therapy. This approach will further the understanding of the interaction between fatty acids in the pathogenesis and progression of the metabolic syndrome.
“Making place” to make IT work: empirical explorations of HCI for mobile CSCW

This paper addresses issues of user interface design, relating to ease of use, of handheld CSCW. In particular, we are concerned with the requirements that arise from situations in which a traditionally designed mobile computer with a small keyboard and screen, may not be easily used. This applies to many mobile use contexts, such as inspection work and engineering in the field. By examining two such settings, we assert that what is usually pointed to as severe shortcomings of mobile computing today, for example: awkward keyboard, small display and unreliable networks, are really implications from a conceptual HCI design that emphasise unstructured, unlimited input; a rich, continuous visual feedback channel and marginal use of sound. We introduce MOTILE, a small prototype that demonstrates some alternative ideas about HCI for mobile devices. We suggest that identifying complementing user interface paradigms for handheld CSCW may enhance our understanding not only of mobile computing or handheld CSCW, but the CSCW field as a whole.
A Modified Loop Filter Design for Digital Symbol Synchronizer

A modified loop filter structure for symbol synchronizer with reduced timing jitter is proposed. A moving average unit (MAU) is added to the traditional proportional-integral (PI) structure to form the modified loop filter. Since the variance of the noise is limited under the average operation, timing jitter is reduced efficiently. Furthermore, the structure is easy for implementation, which requires only one more multiplier, several adders and registers compared to the traditional structure.
MES-1, a protein required for unequal divisions of the germline in early C. elegans embryos, resembles receptor tyrosine kinases and is localized to the boundary between the germline and gut cells.

During Caenorhabditis elegans embryogenesis the primordial germ cell, P(4), is generated via a series of unequal divisions. These divisions produce germline blastomeres (P(1), P(2), P(3), P(4)) that differ from their somatic sisters in their size, fate and cytoplasmic content (e.g. germ granules). mes-1 mutant embryos display the striking phenotype of transformation of P(4) into a muscle precursor, like its somatic sister. A loss of polarity in P(2) and P(3) cell-specific events underlies the Mes-1 phenotype. In mes-1 embryos, P(2) and P(3) undergo symmetric divisions and partition germ granules to both daughters. This paper shows that mes-1 encodes a receptor tyrosine kinase-like protein, though it lacks several residues conserved in all kinases and therefore is predicted not to have kinase activity. Immunolocalization analysis shows that MES-1 is present in four- to 24-cell embryos, where it is localized in a crescent at the junction between the germline cell and its neighboring gut cell. This is the region of P(2) and P(3) to which the spindle and P granules must move to ensure normal division asymmetry and cytoplasmic partitioning. Indeed, during early stages of mitosis in P(2) and P(3), one centrosome is positioned adjacent to the MES-1 crescent. Staining of isolated blastomeres demonstrated that MES-1 was present in the membrane of the germline blastomeres, consistent with a cell-autonomous function. Analysis of MES-1 distribution in various cell-fate and patterning mutants suggests that its localization is not dependent on the correct fate of either the germline or the gut blastomere but is dependent upon correct spatial organization of the embryo. Our results suggest that MES-1 directly positions the developing mitotic spindle and its associated P granules within P(2) and P(3), or provides an orientation signal for P(2)- and P(3)-specific events.
Did States Use Implementation Discretion to Reduce the Stringency of NCLB? Evidence From a Database of State Regulations

When No Child Left Behind (NCLB) became law in 2002, it was viewed as an effort to create uniform standards for students and schools across the country. More than a decade later, we know surprisingly little about how states actually implemented NCLB and the extent to which state implementation decisions managed to undo the centralizing objectives of the law. This paper introduces a state-level measure of NCLB stringency that helps shed light on these issues. The measure is available for 49 states and the District of Columbia and covers most years under NCLB (2003–2011). Importantly, the measure does not depend on population characteristics of the state. It varies only because of state-level decisions about rule exemptions, standards, and proficiency trajectories. Overall, we find that while NCLB was successful in encouraging states to adopt higher and more consistent performance standards for schools, it also provided much more flexibility and customization in state-level accountability policies than is generally realized.
Functional Specialization and Convergence in the Occipito-temporal Cortex Supporting Haptic and Visual Identification of Human Faces and Body Parts: An fMRI Study

Humans can recognize common objects by touch extremely well whenever vision is unavailable. Despite its importance to a thorough understanding of human object recognition, the neuroscientific study of this topic has been relatively neglected. To date, the few published studies have addressed the haptic recognition of nonbiological objects. We now focus on haptic recognition of the human body, a particularly salient object category for touch. Neuroimaging studies demonstrate that regions of the occipito-temporal cortex are specialized for visual perception of faces (fusiform face area, FFA) and other body parts (extrastriate body area, EBA). Are the same category-sensitive regions activated when these components of the body are recognized haptically? Here, we use fMRI to compare brain organization for haptic and visual recognition of human body parts. Sixteen subjects identified exemplars of faces, hands, feet, and nonbiological control objects using vision and haptics separately. We identified two discrete regions within the fusiform gyrus (FFA and the haptic face region) that were each sensitive to both haptically and visually presented faces; however, these two regions differed significantly in their response patterns. Similarly, two regions within the lateral occipito-temporal area (EBA and the haptic body region) were each sensitive to body parts in both modalities, although the response patterns differed. Thus, although the fusiform gyrus and the lateral occipito-temporal cortex appear to exhibit modality-independent, category-sensitive activity, our results also indicate a degree of functional specialization related to sensory modality within these structures.
The Latino Immigrant Labor Experience as Depicted in Film

The author argues that traditional macro-level methods of gathering data on popula- tions create an impersonal depiction of the group. A useful pedagogical tool for teachers to counter this is to use fictional accounts in film and literature to put a more human face on the subjects being studied. Two films, Bread and Roses and El Norte, are used in this way to enhance or add another dimension to studies of the labor experience of Latino immigrants in the United States. The films are looked at through various sociological theories, Assimilation, Competition, and Neo-Marxist. The author concludes that Neo-Marxist theory best predicts the types of con- flict and solidarity portrayed in the films.
An Analytical Model for the Triaxial Collapse of Cosmological Perturbations

We present an analytical model for the non-spherical collapse of overdense regions out of a Gaussian random field of initial cosmological perturbations. The collapsing region is treated as an ellipsoid of constant density, acted upon by the quadrupole tidal shear from the surrounding matter. The dynamics of the ellipsoid is set by the ellipsoid self-gravity and the external quadrupole shear. Both forces are linear in the coordinates and therefore maintain homogeneity of the ellipsoid at all times. The amplitude of the external shear is evolved into the non-linear regime in thin spherical shells that are allowed to move only radially according to the mass interior to them. We describe how the initial conditions can be drawn in the appropriate correlated way from a random field of initial density perturbations. By considering many random realizations of the initial conditions, we calculate the distribution of shapes and angular momenta acquired by objects through the coupling of their quadrupole moment to the tidal shear. The average value of the spin parameter, 0.04, is found to be only weakly dependent on the system mass, the mean cosmological density, or the initial power spectrum of perturbations, in agreement with N-body simulations. For the cold dark matter power spectrum, most objects evolve from a quasi-spherical initial state to a pancake or filament and then to complete virialization. Low-spin objects tend to be more spherical. The evolution history of shapes is primarily induced by the external shear and not by the initial triaxiality of the objects. The statistical distribution of the triaxial shapes of collapsing regions can be used to test cosmological models against galaxy surveys on large scales.
The Topography of Tactile Working Memory

To investigate the contribution of topographically organized brain areas to tactile working memory, we asked human subjects to compare the frequency of two vibrations presented to the same fingertip or to different fingertips. The vibrations ranged from 14 to 24 Hz and were separated by a retention interval of variable length. For intervals <1 sec, subjects were accurate when both vibrations were delivered to the same fingertip but were less accurate when the two vibrations were delivered to different fingertips. For 1 or 2 sec intervals, subjects performed equally well when comparing vibrations delivered either to the same finger or to corresponding fingers on opposite hands, but they performed poorly when the vibrations were delivered to distant fingers on either hand. These results suggest that working memory resides within a topographic framework. As a further test, we performed an experiment in which the two comparison vibrations were presented to the same fingertip but an interference vibration was presented during the retention interval. The interpolated vibration disrupted accuracy most when delivered to the same finger as the comparison vibrations and had progressively less effect when delivered to more distant fingers. We conclude that topographically organized regions of somatosensory cortex contribute to tactile working memory, possibly by holding the memory trace across the retention interval. One stimulus can be accurately compared with the memory of a previous stimulus if they engage overlapping representations, but activation of the common cortical territory by an interpolated stimulus can disrupt the memory trace.
Gender relations, comic books and children's cultures: Between stereotypes and reinventions

The article discusses the production of children's cultures based on the experiences of 3–5-year-old children with the language of comic books, focusing on gender relations. It is part of a doctoral research project conducted at FE / UNICAMP and investigates a case study in a municipal pre-school in the Greater ABC region in São Paulo, Brazil. It assumes that comic books viewed as media production interfere with children's ways of life, often reinforcing stereotypes found in sex differences. Combining philosophy, sociology and childhood education, it discusses how small children interact with comic books and what they reproduce, invent or reinvent when inspired by such materials. It emphasizes that comic books are part of children's material cultures and unveil symbolic aspects of children's cultures, which they share with each other and with adults in such a way that they observe patterns and identity values being negotiated in the sense that not only do they reproduce stereotypes of heteronormative culture, but also cross the boundaries of gender. In sum, the article sheds light on the challenge of bringing children to the debate about gender relations from the perspective of pedagogical proposals which might overcome sexist practices present in educational institutions.
Finite element implementation of the generalized-Lorenz gauged a-Φ formulation for low-frequency circuit modeling

The A-Φ formulation with generalized Lorenz gauge is free of catastrophic breakdown at low frequencies. In the formulation, A and Φ are completely separated and Maxwell's equations are reduced into two independent equations pertinent to A and Φ, respectively. This, however, leads to more complicated equations in contrast to the traditional A-Φ formulation, which makes the numerical representation of the physical quantities challenging, especially for A. By virtue of the differential forms theory and Whitney elements, both A and Φ are appropriately represented. The condition of the resultant matrix system is well-controlled as frequency becomes low, even approaches to 0. The generalized-Lorenz gauged A-Φ formulation is applied to model low-frequency circuits at μm lengthscale.