Miracle-dz/UniFAR-FTUs huggingface dataset:
Minicircle-IFNγ Induces Antiproliferative and Antitumoral Effects in Human Nasopharyngeal Carcinoma

Purpose: The aims of this work were to investigate the antitumor effect of IFNγ gene transfer on human nasopharyngeal carcinoma (NPC) and to assess the potential of minicircle vector for antitumor gene therapy. Experimental Design: We developed a recombinant minicircle vector carrying the human IFNγ gene and evaluated the effects of minicircle-mediated IFNγ gene transfer on NPC cell lines in vitro and on xenografts in vivo. Results: Relative to p2ΦC31-IFNγ, minicircle-mediated IFNγ gene transfer in vitro resulted in 19- to 102-fold greater IFNγ expression levels in transfected cells (293, NIH 3T3, CNE-1, CNE-2, and C666-1) and inhibited the growth of CNE-1, CNE-2, and C666-1 cells more efficiently, reducing relative growth rates to 7.1 ± 1.6%, 2.7 ± 1.0%, and 6.1 ± 1.6%, respectively. Flow cytometry and caspase-3 activity assays suggested that the antiproliferative effects of IFNγ gene transfer on NPC cell lines could be attributed to G0-G1 arrest and apoptosis. Minicircle-mediated intratumoral IFNγ expression in vivo was 11 to 14 times higher than p2ΦC31-IFNγ in CNE-2- and C666-1-xenografted mice and lasted for 21 days. Compared with p2ΦC31-IFNγ treatment, minicircle-IFNγ treatment significantly increased survival and achieved inhibition rates of 77.5% and 83%, respectively. Conclusions: Our data indicate that IFNγ gene transfer exerts antiproliferative effects on NPC cells in vitro and leads to a profound antitumor effect in vivo. Minicircle-IFNγ is more efficient than corresponding conventional plasmids due to its capability of mediating long-lasting high levels of IFNγ gene expression. Therefore, minicircle-mediated IFNγ gene transfer is a promising novel approach in the treatment of NPC.
The TVL1 Model: A Geometric Point of View

The aim of this paper is to investigate the geometrical behavior of the TVL1 model used in image processing, by making use of the notion of Cheeger sets. This mathematical concept was recently related to the celebrated Rudin–Osher–Fatemi image restoration model, yielding important advances in both fields. We provide the reader with a geometrical characterization of the TVL1 model. We show that, in the convex case, exact solutions of the TVL1 problem are given by an opening followed by a simple test over the ratio perimeter/area. Shapes remain or suddenly vanish depending on this test. As a result of our theoretical study, we suggest a new and efficient numerical scheme to apply the model to digital images. As a by-product, we justify the use of the TVL1 model for image decomposition, by establishing a connection between the model and morphological granulometry. Eventually, we propose an extension of TVL1 into an adaptive framework, in which we derive some theoretical results.
How Victim Sensitivity leads to Uncooperative Behavior via Expectancies of Injustice

According to the Sensitivity-to-mean-intentions model, dispositional victim sensitivity involves a suspicious mindset that is activated by situational cues and guides subsequent information processing and behavior like a schema. Study 1 tested whether victim-sensitive persons are more prone to form expectancies of injustice in ambiguous situations and whether these expectancies mediate the relationship between victim sensitivity and cooperation behavior in a trust game. Results show an indirect effect of victim sensitivity on cooperation after unfair treatment (vs. control condition), mediated by expectancies of injustice. In Study 2 we directly manipulated the tendency to form expectancies of injustice in ambiguous situations to test for causality. Results confirmed that the readiness to expect unjust outcomes led to lower cooperation, compared to a control condition. These findings provide direct evidence that expectancy tendencies are implicated in elevated victim sensitivity and are of theoretical and practical relevance.
Modeling of high voltage LDMOSFET using industry standard BSIM6 MOS model

In this paper we have shown the modeling of Lateral Double-Diffused MOS (LDMOS) transistor. A LDMOS structure can be divided into two parts, intrinsic channel and extended drift region. The intinsic channel region is modeled by industry standard BSIM6 model and extended drift region has been modeled by the modified CMC standard model of R3. The R3 model of non-linear resistor, which includes physical effects like velocity-saturation, self-heating etc. has been modified to include gate bias dependency. The new model has been validated with technology computer-aided design (TCAD) simulations and measured data from ON Semiconductor. The model (which is the combination of BSIM6 and R3 models) shows excellent agreement with the TCAD simulations and measured data.
Weakness in numbers

Health literacy is the ability to complete basic reading and numerical tasks required to perform in the health care environment. The specific aspect of literacy that involves solving problems requiring understanding and use of quantitative information is sometimes called numeracy. Numeracy skills include understanding basic calculations, time and money, measurement, estimation, logic, and performing multistep operations. Most importantly, numeracy also involves the ability to infer what mathematic concepts need to be applied when interpreting specific situations, and to use this information to problem solve. Clinicians, clinical care researchers, patient educators, and patients seem to have paid less attention to the numeracy component of health literacy. However, several trends in health care, including patient self-management and patient participation in decision making, strongly argue in favor of change. Two papers published in this issue of the Journal of General Internal Medicine motivate this exploration of the role of numeracy in health care, using the case of diabetes as an example.
A Survey on Anonymity-Based Privacy Preserving

In recent years, with the development of information technology, the operation of enterprises has gone through a drastic revolution. Data information flow became the lifeblood of enterprises. However, in such a situation, people would worry about disclosure of privacy and are likely to provide phony information rather than the authentic. So with the development of data analysis and processing technique, the privacy disclosure problem about individual or company is inevitably exposed when releasing or sharing data to mine useful decision information and knowledge, then give the birth to the research field on privacy preserving. The technology of privacy preserving has become the focus of the researcher home and abroad in recent years. In order to protect individuals' privacy, the technology of anonymity has been proposed to protect sensitive attributes from the corresponding identifiers. This paper intends to reiterate several anonymity-based privacy preserving technologies clearly and then proceeds to analyze the merits and shortcomings of these technologies.
The journey to regulation of protein-based multiplex quantitative assays.

BACKGROUND Clinical proteomics presents great promise in biology and medicine because of its potential for improving our understanding of diseases at the molecular level and for detecting disease-related biomarkers for diagnosis, prognosis, and prediction of therapeutic responses. To realize its full potential to improve clinical outcome for patients, proteomic studies have to be well designed, from biosample cohorts to data and statistical analyses. One key component in the biomarker development pipeline is the understanding of the regulatory science that evaluates diagnostic assay performance through rigorous analytical and clinical review criteria. CONTENT The National Cancer Institute's Clinical Proteomic Technologies for Cancer (CPTC) initiative has proposed an intermediate preclinical "verification" step to close the gap between protein-based biomarker discovery and clinical qualification. In collaboration with the US Food and Drug Administration (FDA), the CPTC network investigators recently published 2 mock submission review documents, first-of-their-kind educational materials that may help the scientific community interested in developing products for the clinic in understanding the likely analytical evaluation requirements for multiplex protein technology-based diagnostic tests. CONCLUSIONS Building on this momentum, the CPTC continues with this report its collaboration with the FDA, as well as its interactions with the AACC and the Centers for Medicare and Medicaid Services, to further the understanding of regulatory requirements for approving multiplex proteomic platform-based tests and analytically validating multiple analytes.
ON THE IMPLEMENTATION OF APPROXIMATE CONDITIONAL INFERENCE

The extension of exact conditional inference to include so-called approximate conditional methods has rapidly developed in the last two decades. However, these methods are still under-used in practice, the main problem being the lack of suitable software. Several attempts have been made to implement the methods, using either computer algebra systems or statistical packages, but none is fully satisfactory. The trade-oo between algebraic calculation and numerical eeciency still represents a big impediment. The aim of the paper is to discuss the problems one encounters in the implementation of higher-order asymptotics and how some of them might be overcome. Sommario Negli ultimi vent'anni si e registrato un interesse crescente nell'inferenza condizion-ata approssimata. Bench e la teoria sia ben formalizzata, le metodologie sviluppate sono tutt'ora poco utilizzate nella pratica statistica, principalmente per la mancanza di adeguati strumenti informatici. Per quanto diversi tentativi di automatizzare tali metodologie siano stati intrapresi, sia nell'ambito di pacchetti di calcolo simbolico, sia in ambienti statistici, nessuna delle proposte e del tutto soddisfacente. Una problematica diicilmente gestibile e rappresentata dal compromesso richiesto per abbinare calcolo algebrico ed eecienza numerica. L'obiettivo di questo lavoro e dis-cutere i problemi legati all'automatizzazione di procedure inferenziali approssimate e presentare alcune possibili soluzioni.
Modelos de inversión social para empresas mineras: experiencias y propuestas

Peru is experiencing a boom through growing mine operations and projects. This has created expectations among the benefi ts that activity may create for the mines’ neighboring communities. Although in most cases results have not been very encouraging, this paper seeks to demonstrate whatever progress has been made in the mining companies’ social management, and the scope of their proposals for improvement by presenting and comparing successful social investment models used in Peru in recent years. It also examines the issue of the mining industry’s voluntary contributions, social contributions and social trust funds, and explains how the money is allocated.
Automatic query expansion and word sense disambiguation with long and short queries using WordNet under vector model

This paper describes the experimentation conducted to test the effectiveness of automatic query expansion and word sense disambiguation (WSD) using short and long query of a topic TREC under vector model. We ran different experiments generating queries under vector model using linguistic information extracted from WordNet. Results show that query expansion with short queries and long queries is not able to improve retrieval performance without the selection of the correct meaning of the words but the results are better using short queries.
Regression of Established Human Papillomavirus Type 16 (HPV-16) Immortalized Tumors In Vivo by Vaccinia Viruses Expressing Different Forms of HPV-16 E7 Correlates with Enhanced CD8+ T-Cell Responses That Home to the Tumor Site

ABSTRACT Using vaccinia virus as a live vector, we show that the expression of human papillomavirus type 16 (HPV-16) E7 fused to a nonhemolytic portion of the Listeria monocytogenes virulence factor, listeriolysin O (LLO), induces an immune response that causes the regression of established HPV-16 immortalized tumors in C57BL/6 mice. The vaccinia virus construct expressing LLO fused to E7 (VacLLOE7) was compared with two previously described vaccinia virus constructs: one that expresses unmodified E7 (VacE7) and another that expresses E7 in a form designed to direct it to intracellular lysosomal compartments and improve major histocompatibility complex class II-restricted responses (VacSigE7LAMP-1). C57BL/6 mice bearing established HPV-16 immortalized tumors of 5 or 8 mm were treated with each of these vaccines. Fifty percent of the mice treated with VacLLOE7 remained tumor free 2 months after tumor inoculation, whereas 12 to 25% of the mice were tumor free after treatment with VacSigE7LAMP-1 (depending on the size of the tumor). No mice were tumor free in the group given VacE7. Compared to VacE7, VacSigE7LAMP-1 and VacLLOE7 resulted in increased numbers of H2-Db-specific tetramer-positive CD8+ T cells in mouse spleens that produced gamma interferon and tumor necrosis factor alpha upon stimulation with RAHYNIVTF peptide. In addition, the highest frequency of tetramer-positive T cells was seen in the tumor sites of mice treated with VacLLOE7. An increased efficiency of E7-specific lysis by splenocytes from mice immunized with VacLLOE7 was also observed. These results indicate that the fusion of E7 with LLO not only enhances antitumor therapy by improving the tumoricidal function of E7-specific CD8+ T cells but may also increase the number of antigen-specific CD8+ T cells in the tumor, the principle site of antigen expression.
Electromagnetic properties of chloroprene rubber after long-term ultraviolet ageing, oil immersion and thermal degradation

The electromagnetic properties of chloroprene rubber after long-term ultraviolet ageing, oil immersion and thermal degradation were experimentally investigated in the frequency range from 1 kHz up to 1 THz. Ageing was shown in terms of mechanical degradation and the change in the complex dielectric permittivity. Within the whole investigated frequency range decrease of dielectric permittivity was observed after thermal treatment combined with oil immersion in comparison with chloroprene rubber stored under normal conditions. In contrast, thermal and ultraviolet ageing without immersion leads to increase of rubbers dielectric permittivity in all investigated frequency ranges. A non-invasive express method of degradation detection is proposed and proofed.
The Effect of Human Resource Management Practices on firm ' s Competitive Advantage : Role of Dynamic Capabilities and Uncertain Environment

Effective HRM practices can lead to superior independent innovation. Nevertheless, the mechanism between these two has not been carefully identified. Using the survey data, the paper examines the relationship among HRM practices, dynamic capabilities and independent innovation. The results from structural equation analysis indicate that the effective HRM practices can increase the flexible organization, organizational learning, resources integration and environmental perception. Dynamic capabilities can enhance the competitive advantage. But uncertain environment does act as moderator between dynamic capabilities and competitive
Deterministic Diffusion

We present a series of definitions and properties of lifting dynamical systems (LDS) corresponding to the notion of deterministic diffusion. We give heuristic explanations of the mechanisms of formation of deterministic diffusion in LDS and the anomalous deterministic diffusion in the case of transportation in long billiard channels with spatially periodic structures and nonideal reflection law. The expressions for the coefficient of deterministic diffusion are obtained.
Green synthesis of anisotropic gold nanoparticles using cinnamon with superior antibacterial activity

Stable gold nanoparticles have been synthesized by one step, cost effective and environment friendly technique at room temperature using the natural spice cinnamon. The synthesized nanoparticles have been characterized using Ultraviolet visible spectroscopy, x-ray diffraction, Fourier transform infrared spectroscopy and Transmission electron microscopy. Transmission electron microscopy images confirm the presence of spherical and anisotropic nanoparticles of different shapes that include triangular, hexagonal and some spherical shaped nanoparticles. The decreased symmetry of anisotropic nanoparticle gives rise to unique optical properties. The antibacterial activity of nanoparticles has also been studied.
Growth Temperature and Genome Size in Bacteria Are Negatively Correlated, Suggesting Genomic Streamlining During Thermal Adaptation

Prokaryotic genomes are small and compact. Either this feature is caused by neutral evolution or by natural selection favoring small genomes—genome streamlining. Three separate prior lines of evidence argue against streamlining for most prokaryotes. We find that the same three lines of evidence argue for streamlining in the genomes of thermophile bacteria. Specifically, with increasing habitat temperature and decreasing genome size, the proportion of genomic DNA in intergenic regions decreases. Furthermore, with increasing habitat temperature, generation time decreases. Genome-wide selective constraints do not decrease as in the reduced genomes of host-associated species. Reduced habitat variability is not a likely explanation for the smaller genomes of thermophiles. Genome size may be an indirect target of selection due to its association with cell volume. We use metabolic modeling to demonstrate that known changes in cell structure and physiology at high temperature can provide a selective advantage to reduce cell volume at high temperatures.
Difficult Airway Society 2015 guidelines for management of unanticipated difficult intubation in adults

These guidelines provide a strategy to manage unanticipated difficulty with tracheal intubation. They are founded on published evidence. Where evidence is lacking, they have been directed by feedback from members of the Difficult Airway Society and based on expert opinion. These guidelines have been informed by advances in the understanding of crisis management; they emphasize the recognition and declaration of difficulty during airway management. A simplified, single algorithm now covers unanticipated difficulties in both routine intubation and rapid sequence induction. Planning for failed intubation should form part of the pre-induction briefing, particularly for urgent surgery. Emphasis is placed on assessment, preparation, positioning, preoxygenation, maintenance of oxygenation, and minimizing trauma from airway interventions. It is recommended that the number of airway interventions are limited, and blind techniques using a bougie or through supraglottic airway devices have been superseded by video- or fibre-optically guided intubation. If tracheal intubation fails, supraglottic airway devices are recommended to provide a route for oxygenation while reviewing how to proceed. Second-generation devices have advantages and are recommended. When both tracheal intubation and supraglottic airway device insertion have failed, waking the patient is the default option. If at this stage, face-mask oxygenation is impossible in the presence of muscle relaxation, cricothyroidotomy should follow immediately. Scalpel cricothyroidotomy is recommended as the preferred rescue technique and should be practised by all anaesthetists. The plans outlined are designed to be simple and easy to follow. They should be regularly rehearsed and made familiar to the whole theatre team.
Corporate equity refinancing and cash dividend in China: Based on the perspective of moral hazard

There are two main ways for listed companies to realize fund allocation, equity refinancing and cash-dividend paying. The former is the source of equity fund; the latter is the use of equity capital and the returns to investors. In recent years, China Securities Regulatory Commission has issued a series of policies, in order to improve the cash dividend payout ratio before equity refinancing. In this background, there are more and more companies that refinance and pay cash dividend in the same year. This paper analyzes the relativity of equity financing and cash-dividend paying. This paper takes A-share stocks from 2007 to 2012 which have two events in Chinese securities market for a sample, and verifies the hypothesis that large shareholders' moral hazard does exist, from three aspects including announcement effect, financial performance and tunneling. The conclusions are as follows: The constraints of cash dividend paying has different effect on market reaction of different ways of equity refinancing; the samples with different sequences of cash dividend paying and equity refinancing have different equity financing announcement effect; different sequences of two events lead to different cash dividend paying announcement effect; by building performance rating model using financial indicators, I find that issue-dividend sample sores lower; the issue-dividend sample has higher discount rate and cash dividend payout ratio, thus tunneling directly to controlling shareholders.
Inhibition of bactericidal activity of anticapsular antibody by nonspecific antibodies reactive with surface-exposed antigenic determinants on Actinobacillus pleuropneumoniae

In an attempt to understand the mechanism of serum resistance in Actinobacillus pleuropneumoniae, in the present study we examined various interactions among the bacterial surface constituents, serum antibodies, and complement. Analysis of swine sera revealed the presence of anticapsular antibodies in convalescent-phase sera but not in preimmune sera. Both types of sera contained antibodies which reacted with each of 14 polypeptides present in saline extracts of the bacteria. Absorption of the preimmune sera with intact bacteria depleted antibodies to two of the polypeptides (27 and 32 kDa) and high-molecular-weight (greater than 97.4,000) components which did not stain with Coomassie blue. Data derived from complement consumption and C3-binding experiments indicated that the organism was capable of initiating complement activation and binding C3 during incubation in preimmune and immune sera. Experiments designed to evaluate the bactericidal effectiveness of anticapsular antibody revealed that the purified antibody was bactericidal only when preimmune sera absorbed with intact bacteria were used as a source of complement. The bactericidal effects of anticapsular antibody and absorbed preimmune sera were inhibited in a dose-dependent manner by heat-inactivated preimmune sera and immunoglobulin G derived from the sera. The inhibitory activity of the preimmune sera was neutralized by preincubating the sera with column fractions of the saline extract which contained either the 27- or the 32-kDa polypeptide. These results indicate that serum resistance in A. pleuropneumoniae 4074 could be related to inhibition of the bactericidal action of anticapsular antibody by nonspecific antibodies which recognize surface-exposed epitopes on the polypeptides.
Privacy Preserving Data Processing

A data processing functions are expected as a key-issue of knowledge-intensive service functions in the Cloud computing environment. Cloud computing is a technology that evolved from technologies of the field of virtual machine and distributed computing. However, these unique technologies brings unique privacy and security problems concerns for customers and service providers due to involvement of expertise (such as knowledge, experience, idea, etc.) in data to be processed. We propose the cryptographic protocols preserving the privacy of users and confidentiality of the problem solving servers.