Miracle-dz/UniFAR-FTUs huggingface dataset:
Design of InGaN-GaN-AlGaN vertical-cavity surface-emitting lasers using electrical-thermal-optical simulation

A three-dimensional electrical-thermal-optical numerical simulator is developed and applied to model group-III-nitride-based intracavity-contacted vertical-cavity surface-emitting lasers with InGaN multiquantum-well active region. The optical model based on the effective frequency method is combined with an electrical-thermal simulator using the control volume method. Isothermal (pulsed regime imitation) and continuous-wave modes of operation are calculated over a range of voltages, covering subthreshold spontaneous emission and lasing emission. Effects of current crowding at the active region periphery are examined, and in particular, an impact on mode profiles of spatial hole burning superimposed on nonuniform gain distribution is studied. In order to reduce the current crowding and provide more uniform gain distribution within the active region, a semitransparent p-side contact design is proposed.
Is It the Judge, the Sender, or Just the Individual Message? Disentangling Person and Message Effects on Variation in Lie-Detection Judgments

Research suggests that people differ more in their ability to lie than in their ability to detect lies. However, because studies have not treated senders and messages as separate entities, it is unclear whether some senders are generally more transparent than others or whether individual messages differ in their transparency of veracity regardless of senders. Variance attributable to judges, senders, and messages was estimated simultaneously using multiple messages from each sender (totaling more than 45,000 judgments). The claim that the accuracy of a veracity judgment depends on the sender was not supported. Messages differed in their detectability (21% explained variance), but senders did not. Message veracity accounted for most message variation (16.8% of the total variance), but other idiosyncratic message characteristics also contributed significantly. Consistent with the notion that a (mis)match between sender demeanor and veracity determines accuracy, lie and truth detectability differed individually within senders. Judges primarily determined variance in lie-versus-truth classifications (12%) and in confidence (46%) but played no role regarding judgment accuracy (< 0.01%). This work has substantial implications for the design and direction of future research and underscores the importance of separating senders and messages when developing theories and testing derived hypotheses.
The increasing antimicrobial resistance of Shigella species among Iranian pediatrics: a systematic review and meta-analysis

ABSTRACT Background Shigellosis remains one of the global causes of morbidity and mortality. However, the global emergence of antibiotic resistance has become the leading cause of treatment failure in shigellosis. This review aimed to provide an updated picture of the antimicrobial resistance rates in Shigella species in Iranian pediatrics. Methods A comprehensive systematic search was performed on PubMed, Scopus, Embase, and Web of Science until 28 July 2021. The meta-analysis was performed by computing the pooled using a random-effects model with Stata/SE software, v.17. 1. The discrepancy within articles was surveyed by the forest plot in addition to the I2 statistic. All statistical interpretations were reported on a 95% confidence interval (CI) basis. Results Totally, of 28 eligible studies published between 2008 and 2021. The pooled prevalence rate of multidrug-resistant (MDR) was 63% (95% CI 50–76). Regarding suggested antimicrobial agents for Shigella species, the prevalence of resistance for ciprofloxacin, azithromycin, and ceftriaxone as first- and second-line treatments for shigellosis were 3%, 30%, and 28%, respectively. In contrast, resistance to cefotaxime, cefixime, and ceftazidime was 39%, 35%, and 20%. Importantly, subgroup analyses indicated that an increase in resistance rates during the periods (2008–2014, 2015–2021) was recognized for ciproﬂoxacin (0 % to 6%) and ceftriaxone (6% to 42%). Conclusion Our findings revealed that ciprofloxacin is an effective drug for shigellosis in Iranian children. The substantially high prevalence estimation proposes that the first- and second-line treatments for shigellosis are the major threat to public health and active antibiotic treatment policies are essential.
Lithographied nanostructures as nanosensors

Major improvements in fabrication techniques at the nanoscale during the last two decades enable us to exploit and control nanoscale phenomena such as the localized surface plasmons (LSP) provided by metallic nanoparticles (MNP). The large enhancement of the electromagnetic field due to plasmonic effects increases drastically the response of any analyte located close to or adsorbed on MNPs, which opens ways for detection of very low concentration of analytes and sensor miniaturization. However, the efficiency of such nanosensors requires a precise control of the optical properties of the MNPs since it strongly depends on their geometrical properties. Such precision can be reached by nanolithography techniques. The parameters that govern the near field enhancement include the geometrical parameters of the MNPs (size, shape, and gap), the LSP characteristics (near field decay length and resonance position) and the excitation parameters (excitation wavelength and associated electric field polarization). Nanolithography techniques used for surface nanostructuring include optical, focused electron and ion beams, nanoimprint and nanosphere lithographies. Nanosensor fabricated lithographically exploit localized surface plasmon resonance, surface enhanced Raman scattering, and surface enhanced fluorescence.
Arthropod-borne diseases among travellers arriving in Europe from Africa, 2015 to 2019

Background Travellers are generally considered good sentinels for infectious disease surveillance. Aim To investigate whether health data from travellers arriving from Africa to Europe could provide evidence to support surveillance systems in Africa. Methods We examined disease occurrence and estimated risk of infection among travellers arriving from Africa to Europe from 2015 to 2019 using surveillance data of arthropod-borne disease cases collected through The European Surveillance System (TESSy) and flight passenger volumes from the International Air Transport Association. Results Malaria was the most common arthropod-borne disease reported among travellers from Africa, with 34,235 cases. The malaria travellers’ infection rate (TIR) was 28.8 cases per 100,000 travellers, which is 36 and 144 times higher than the TIR for dengue and chikungunya, respectively. The malaria TIR was highest among travellers arriving from Central and Western Africa. There were 956 and 161 diagnosed imported cases of dengue and chikungunya, respectively. The highest TIR was among travellers arriving from Central, Eastern and Western Africa for dengue and from Central Africa for chikungunya in this period. Limited numbers of cases of Zika virus disease, West Nile virus infection, Rift Valley fever and yellow fever were reported. Conclusions Despite some limitations, travellers’ health data can efficiently complement local surveillance data in Africa, particularly when the country or region has a sub-optimal surveillance system. The sharing of anonymised traveller health data between regions/continents should be encouraged.
Factor graphs: constructions, classification, and bounds

The representation of codes by factor graphs provides a general framework for iterative decoding, and has become a subject of much research. We address the following problem: given a factor graph G and a code C how can one construct the set of local behaviors for G so that G represents C in the most efficient manner? In this context, we introduce the notion of trellis formations, and obtain a classification of factor graphs into several types, based on this notion. We then describe a general construction of local behaviors for trellis formations, which generalizes the product construction for conventional trellises. In both cases, the goal of the construction is to obtain state-space sizes that are as small as possible. We also investigate bounds on the size of trellis formations and the size of local behaviors in factor graphs.
Robust Control Design Based-On Integral Sliding-Mode Control

This paper proposes a robust control design based-on integral sliding-mode and H2–norm performance criterion to handle a class of time-varying systems with perturbations including non-linearities and disturbances. The stabilization problems for such systems are studied: integral slid-ing-mode is designated to completely nullify the matched perturbations and, in the meantime, elim-inate the reaching phase to the sliding surface, while H2–norm is a robust linear control measured for system on the sliding surface. In addition to the integral sliding mode control, the contribution of the paper is to implement a parameter-dependent Lyapunov function for H2–norm robust linear control that the overall designed system is less conservative for the system with both matched and unmatched perturbations.
On the LQG and LQG/LTR methodology

The paper considers the well-known linear quadratic Gaussian with loop transfer recovery (LQG/LTR) methodology as a special case of standard LQG methodology. In another words, problems solved using LQG/LTR methodology can equally be solved by the standard LQG methodology. In this way we can directly tackle the problem we want to solve. Proof is given to show how LQG/LTR methodology is related to LQG methodology.
Effects of a household air pollution intervention using liquefied petroleum gas stoves, continuous fuel distribution and behavioural messaging on dietary and sodium intake of adult women in Puno, Peru: a randomised controlled trial

Abstract Objective: Household air pollution (HAP) is a widespread environmental exposure worldwide. While several cleaner fuel interventions have been implemented to reduce personal exposures to HAP, it is unclear if cooking with cleaner fuels also affects the choice of meals and dietary intake. Design: Individually randomised, open-label controlled trial of a HAP intervention. We aimed to determine the effect of a HAP intervention on dietary and Na intake. Intervention participants received a liquefied petroleum gas (LPG) stove, continuous fuel delivery and behavioural messaging during 1 year whereas control participants continued with usual cooking practices that involved the use of biomass-burning stoves. Dietary outcomes included energy, energy-adjusted macronutrients and Na intake at baseline, 6 months and 12 months post-randomisation using 24-h dietary recalls and 24-h urine. We used t-tests to estimate differences between arms in the post-randomisation period. Setting: Rural settings in Puno, Peru. Participants: One hundred women aged 25–64 years. Results: At baseline, control and intervention participants were similar in age (47·4 v. 49·5 years) and had similar daily energy (8894·3 kJ v. 8295·5 kJ), carbohydrate (370·8 g v. 373·3 g) and Na intake (4·9 g v. 4·8 g). One year after randomisation, we did not find differences in average energy intake (9292·4 kJ v. 8788·3 kJ; P = 0·22) or Na intake (4·5 g v. 4·6 g; P = 0·79) between control and intervention participants. Conclusions: Our HAP intervention consisting of an LPG stove, continuous fuel distribution and behavioural messaging did not affect dietary and Na intake in rural Peru.
A comparison of the accuracy of mushroom identification applications using digital photographs

Abstract Objective To compare the accuracy of three popular mushroom identification software applications in identifying mushrooms involved in exposures reported to the Victorian Poisons Information Centre and Royal Botanic Gardens Victoria. Background Over the past 10 years, an increasing number of software applications have been developed for use on smart phones and tablet devices to identify mushrooms. We have observed an increase in poisonings after incorrect identification of poisonous species as edible, using these applications. Design We compared the accuracy of three iPhone™ and Android™ mushroom identification applications: Picture Mushroom (Next Vision Limited©), Mushroom Identificator (Pierre Semedard©), and iNaturalist (iNaturalist, California Academy of Sciences©). Each app was tested independently by three researchers using digital photographs of 78 specimens sent to the Victorian Poisons Information Centre and Royal Botanic Gardens Victoria over a two-year period, 2020–2021. Mushroom identification was confirmed by an expert mycologist. For each app, individual and combined results were compared. Results Picture Mushroom was the most accurate of the three apps and correctly identified 49% (95% CI [0–100]) of specimens, compared with Mushroom Identificator (35% [15–56]) and iNaturalist (35% [0–76]). Picture Mushroom correctly identified 44% of poisonous mushrooms [0–95], compared with Mushroom Identificator (30% [1–58]) and iNaturalist (40% [0–84), but Mushroom Identificator identified more specimens of Amanita phalloides correctly (67%), compared to Picture Mushroom (60%) and iNaturalist (27%). Amanita phalloides was falsely identified, twice by Picture Mushroom and once by iNaturalist. Conclusions Mushroom identification applications may be useful future tools to assist clinical toxicologists and the general public in the accurate identification of mushrooms species but, at present, are not reliable enough to exclude exposure to potentially poisonous mushrooms when used alone.
Small-Scale Brightenings in the UV Continuum of an M9.1 Solar Flare

We analyze an M9.1 two-ribbon solar flare which occurred on 2004 July 22 using the TRACE white-light and 1700 A images, the RHESSI, and the SOHO/MDI data. We find many small-scale fast-varying brightenings that appeared in the white-light and 1700 A images along the flare ribbons. Some of them underwent rapid motions in weak magnetic field regions. We identify these short-lived brightenings as UV continuum enhancement. Our preliminary result shows that the brightenings are closely related to the HXR emission. They have a lifetime of 30–60 s and a typical size of about 1''–2''. The intensity enhancement is about 150–200 times the mean value of the quiet-Sun. According to previous works, we infer that the 1700 A enhancement may be dominated by the increased emission of 1680 A continuum coming from the temperature minimum region. The impulsive feature in the 1700 A light curves of the small-scale brightenings may be due to the irradiation of the impulsive CIV line intensity caused by the bombardment of non-thermal electron beams.
Associations of Life's Simple 7 with cerebral white matter hyperintensities and microstructural integrity: UK Biobank cohort study

The American Heart Association Life's Simple 7 (LS7) metric was used to define optimal cardiovascular and brain health, but the associations with macrostructural hyperintensities and microstructural white matter damage are unclear. The objective was to determine the association of LS7 ideal cardiovascular health factors with macrostructural and microstructural integrity.
Exosome Cell Origin Affects In Vitro Markers of Tendon Repair in Ovine Macrophages and Tenocytes

Tendon injuries and disease are resistant to surgical repair; thus, adjunct therapies are widely investigated, especially mesenchymal stromal cells (MSCs) and, more recently, their extracellular vesicles (MSCdEVs), for example, exosomes. Thought to act on resident and infiltrating immune cells, the role of MSCdEVs in paracrine signaling is of great interest. This study investigated how MSCdEVs differ from analogs derived from resident (tenocyte) populations (TdEV). As macrophages play a significant role in tendon maintenance and repair, macrophage signaling was compared by cytokine quantification using a multiplexed immunoassay and tenocyte migration by in vitro scratch-wound analysis. TdEV-treated macrophages decreased IL-1 and increased MIP-1 and CXCL8 expression. In addition, macrophage signaling favored collagen synthesis and tenocyte bioactivity, while reducing proangiogenic signaling when TdEVs were used in place of MSCdEVs. These in vitro data demonstrate a differential influence of exosomes on macrophage signaling, according to cell source, supporting that local cell-derived exosomes may preferentially drive healing by different means with possible different outcomes compared to MSCdEVs. Impact Statement Adipose-derived mesenchymal stromal cell (AdMSC) exosomes (EVs) can improve tendon mechanical resilience, tissue organization, and M2 macrophage phenotype predominance in response to tendon injury. This active area of investigation drives great interest in the function of these exosomes as adjunct therapies for tendon disease, particularly rotator cuff tendinopathy. However, little is known about the effects of EVs as a function of cell source, nor regarding their efficacy in preclinical translational ovine models. Herein we demonstrate a differential effect of exosomes as a function of cell source, tenocyte compared to AdMSCs, on macrophage signaling and tenocyte migration of ovine cells.
Racial Inequities in Sepsis Mortality Among Children in the United States

Background: Racial inequities influence health outcomes in the United States, but their impact on sepsis outcomes among children is understudied. We aimed to evaluate for racial inequities in sepsis mortality using a nationally representative sample of pediatric hospitalizations. Methods: This population-based, retrospective cohort study used the 2006, 2009, 2012 and 2016 Kids’ Inpatient Database. Eligible children 1 month to 17 years old were identified using sepsis-related International Classification of Diseases, Ninth Revision or International Classification of Diseases, Tenth Revision codes. We used modified Poisson regression to evaluate the association between patient race and in-hospital mortality, clustering by hospital and adjusting for age, sex and year. We used Wald tests to assess for modification of associations between race and mortality by sociodemographic factors, geographic region and insurance status. Results: Among 38,234 children with sepsis, 2555 (6.7%) died in-hospital. Compared with White children, mortality was higher among Hispanic (adjusted relative risk: 1.09; 95% confidence interval: 1.05–1.14), Asian/Pacific Islander (1.17, 1.08–1.27) and children from other racial minority groups (1.27, 1.19–1.35). Black children had similar mortality to White children overall (1.02, 0.96–1.07), but higher mortality in the South (7.3% vs. 6.4%; P < 0.0001). Hispanic children had higher mortality than White children in the Midwest (6.9% vs. 5.4%; P < 0.0001), while Asian/Pacific Islander children had higher mortality than all other racial categories in the Midwest (12.6%) and South (12.0%). Mortality was higher among uninsured children than among privately insured children (1.24, 1.17–1.31). Conclusions: Risk of in-hospital mortality among children with sepsis in the United States differs by patient race, geographic region and insurance status.
Lateral track control of UAVs using the sliding mode approach: from design to flight testing

This paper develops sliding-mode-based nonlinear logic for guidance of unmanned aerial vehicles (UAVs) for curved and straight path following. UAV trajectories generally consist of straight path segments, curved arcs, circular loiters and other manoeuvres; tight ground track control is desired throughout the trajectory. This is achieved by controlling the lateral (cross-track) deviation of the vehicle in flight. The main objective of the guidance algorithm is to keep the lateral track error of the vehicle as small as possible while performing graceful and stable manoeuvres despite the presence of uncertainties and disturbing winds. Lateral track control is usually achieved by banking the vehicle, that is, by executing roll manoeuvres. The scheme must perform well without saturating the roll angle of the vehicle, which serves as the control input for the guidance algorithm. The algorithm proposed here is shown to perform well for both straight and circular path tracking while ensuring control boundedness, and hence no saturation. Crosswinds are a major source of disturbance for the guidance problem. This is incorporated into the design formulation and guidance gains are selected to provide the desired performance despite the presence of disturbing winds. A sliding-mode-based scheme is developed which includes a feedforward component related to the rate of change of the desired path heading. Stability of the algorithm is proved using an appropriate Lyapunov function. The algorithm is implemented in the flight control computer of a scaled YAK-54 research aircraft; flight test results are presented and compared with those from other guidance algorithms. Flight results demonstrate the effectiveness and performance of the proposed guidance scheme. The algorithm considers guidance in the 2D lateral plane only and minimizes deviations from the desired ground track of the vehicle.
Hollow-fibre system model of tuberculosis reproducibility and performance specifications for best practice in drug and combination therapy development

Abstract Background The hollow-fibre system model of tuberculosis (HFS-TB) has been endorsed by regulators; however, application of HFS-TB requires a thorough understanding of intra- and inter-team variability, statistical power and quality controls. Methods Three teams evaluated regimens matching those in the Rapid Evaluation of Moxifloxacin in Tuberculosis (REMoxTB) study, plus two high-dose rifampicin/pyrazinamide/moxifloxacin regimens, administered daily for up to 28 or 56 days against Mycobacterium tuberculosis (Mtb) under log-phase growth, intracellular growth or semidormant growth under acidic conditions. Target inoculum and pharmacokinetic parameters were pre-specified, and the accuracy and bias at achieving these calculated using percent coefficient of variation (%CV) at each sampling point and two-way analysis of variance (ANOVA). Results A total of 10 530 individual drug concentrations, and 1026 individual cfu counts were measured. The accuracy in achieving intended inoculum was >98%, and >88% for pharmacokinetic exposures. The 95% CI for the bias crossed zero in all cases. ANOVA revealed that the team effect accounted for <1% of variation in log10 cfu/mL at each timepoint. The %CV in kill slopes for each regimen and different Mtb metabolic populations was 5.10% (95% CI: 3.36%–6.85%). All REMoxTB arms exhibited nearly identical kill slopes whereas high dose regimens were 33% faster. Sample size analysis revealed that at least three replicate HFS-TB units are needed to identify >20% difference in slope, with a power of >99%. Conclusions HFS-TB is a highly tractable tool for choosing combination regimens with little variability between teams, and between replicates.
Luminescence properties of nanocrystalline Y2O3:Eu3+ in different host materials

In this study, the optical properties of nanocrystalline europium doped yttria, Y2O3:Eu3+ were investigated in dependence on different caging hosts such as porous MCM-41, porous silica, and porous alumina with pore sizes ranging between 2.7 to 80 nm. These results were compared to nanopowders measured in air and aqueous solution whose particle sizes were 5 nm and 8 nm, respectively. All these results were compared to a commercial lamp phosphor powder with a grain size of about 5 μm. The structural properties of the samples were determined by x-ray diffraction and transmission electron microscopy. Investigated optical properties are the photoluminescence emission spectra, the excitation spectra, the lifetimes, and the quantum efficiencies. A heavy dependence of the charge transfer process on the surrounding will be reported and discussed.