Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterization and architectural implications of big data workloads

The previous major efforts on big data benchmark either propose a large amount of workloads (e.g. a recent comprehensive big data benchmark suite - BigDataBench [4]), which impose cognitive difficulty on workload characterization and serious benchmarking cost; or only select a few workloads according to so-called popularity[1], which lead to partial or biased observations.
Beyond Involvement

With many states adopting new standards and evaluation systems, teachers must adopt effective instructional strategies and assessment methods aligned to the rigor of new standards and assessments. One way to improve student achievement is through supporting student ownership of learning, a core component of formative instructional practices. Teaching students to take an active role in their learning can benefit students by promoting student goal setting, self-assessment, and self-determination. As students become meaningfully engaged in their learning, they gain a better understanding of learning targets, how to collect and document evidence of their learning, and how to evaluate and clarify additional learning needs, leading to the ultimate goal of improving student achievement. This article (a) describes how promoting student ownership benefits students, (b) identifies some evidence-based practices that promote student ownership of learning, and (c) illustrates the important role student ownership plays in formative instructional practices.
A response to a case of Lacanian psychosis: a cognitive behaviour therapy perspective

Cognitive behaviour therapy (CBT) for psychosis has been emphasized over the last decade within research in schizophrenia and in bipolar disorders. Perhaps surprisingly for a psychotherapy that is better known as a treatment for depression and anxiety disorders, the paper by Aaron Beck that first introduced the CBT model in 1952 addressed the treatment of a case of psychosis. CBT practitioners have therefore offered CBT treatments for psychosis over several decades, but it is only more recently that large-scale outcome research has provided support for the effectiveness of CBT in psychosis (Turkington and Siddle 1998). The following discussion aims to provide some comments on the clinical case of Helen from a cognitive behaviour therapy perspective and is based solely upon the descriptions contained within the case report.
Molecular basis of synaptic vesicle cargo recognition by the endocytic sorting adaptor stonin 2

Synaptic transmission depends on clathrin-mediated recycling of synaptic vesicles (SVs). How select SV proteins are targeted for internalization has remained elusive. Stonins are evolutionarily conserved adaptors dedicated to endocytic sorting of the SV protein synaptotagmin. Our data identify the molecular determinants for recognition of synaptotagmin by stonin 2 or its Caenorhabditis elegans orthologue UNC-41B. The interaction involves the direct association of clusters of basic residues on the surface of the cytoplasmic domain of synaptotagmin 1 and a β strand within the μ–homology domain of stonin 2. Mutation of K783, Y784, and E785 to alanine within this stonin 2 β strand results in failure of the mutant stonin protein to associate with synaptotagmin, to accumulate at synapses, and to facilitate synaptotagmin internalization. Synaptotagmin-binding–defective UNC-41B is unable to rescue paralysis in C. elegans stonin mutant animals, suggesting that the mechanism of stonin-mediated SV cargo recognition is conserved from worms to mammals.
When banking on meaning is not (yet) money in the bank: Explorations in connectionist modeling.

A number of reports claim that humans perform lexical decisions faster to words with many meanings than to words with only one meaning. It is a challenge to simulate this ambiguity effect with a parallel distributed processing model because activation of ambiguous words produces competition at the semantic level; this ought to lead to less rather than more efficient processing of ambiguous words. Despite this problem, the present simulations show that it is possible to produce an ambiguity effect when the network settles into a learned semantic pattern through use of a proximity factor. However, competition is not completely countered by proximity as the network fails to settle into a learned semantic pattern for ambiguous words on more than 50% of the trials. Further simulations show that manipulations that increase the proportion of correct settling result in the loss of thi ambiguity effect
Heteromultimerization of G-Protein-Gated Inwardly Rectifying K+ Channel Proteins GIRK1 and GIRK2 and Their Altered Expression in weaver Brain

The weaver (wv) gene (GIRK2) is a member of the G-protein-gated inwardly rectifying potassium (GIRK) channel family, known effectors in the signal transduction pathway of neurotransmitters such as acetylcholine, dopamine, opioid peptides, and substance P in modulation of neurotransmitter release and neuronal excitability. GIRK2 immunoreactivity is found in but not limited to brain regions known to be affected in wv mice, such as the cerebellar granule cells and dopaminergic neurons in the substantia nigra pars compacta. It is also observed in the ventral tegmental area, hippocampus, cerebral cortex, and thalamus. GIRK2 and GIRK1, a related family member, have overlapping yet distinct distributions in rat and mouse brains. In regions where both channel proteins are expressed, such as the cerebral cortex, hippocampus, and cerebellum, they can be co-immunoprecipitated, indicating that they interact to form heteromeric channels in vivo. In the brain of thewv mouse, GIRK2 expression is decreased dramatically. In regions where GIRK1 and GIRK2 distributions overlap, both GIRK1 and GIRK2 expressions are severely disrupted, probably because of their co-assembly. The expression patterns of these GIRK channel subunits provide a basis for consideration of the machinery for neuronal signaling as well as the differential effects of the wvmutation in various neurons.
Role of double-plane high tibial osteotomy in the repair of posterolateral complex damage with bad lower limb force line

Objective: To investigate the role of double-plane high tibial osteotomy in the repair of Posterolateral Complex (PLC) damage with bad lower limb force line. Methods: A total of 56 cases of patients with PLC injuries who were admitted to our hospital from February 2015 to November 2016 were divided into the study group (n=28) and the control group (n=28) using the random distribution method. The patients in the study group underwent double-plane high tibial osteotomy, whereas the patients in the control group underwent the conventional conservative treatment method. The relative position of the mechanical axis of the lower limb passing through the tibia, the tibial caster angle, the tibial retroposition distance, and the lateral interval opening degree of the patients were compared 1 year postoperative. The postoperative joint function was evaluated using the Lysholm scoring system. Results: The relative position of the mechanical axis of the lower limb passing through the tibia and the tibial caster angle recovery of the patients in the study group were higher than those of the patients in the control group. By contrast, the tibial retroposition distance and the lateral interval opening degree of the patients in the study group were lower than those of the patients in the control group, and the difference was statistically significant (P<0.05). The Lysholm score of the patients in the study group was significantly higher than that of the patients in the control group, and the difference was statistically significant (χ2=4.9088, P=0.0267). Conclusion: PLC damage of the knee joint with bad lower limb force line was treated with double-plane high tibial osteotomy. The postoperative effect was satisfactory, and knee function recovery was better compared with that of conventional treatment. Such results are worth popularizing.
A planar feed for SOTM Ka-band lens antennas

Ka-band satellite technology has been drawing growing interest from public transportation industry to military applications, due to its advantages of higher speed links, smaller terminals and reduced costs. These well-recognized characteristics have also boosted the interest in exploiting the Ka-band devices for personal use in small boats or all-terrain vehicles. This paper presents a simple, low-cost and compact mobile ground terminal antenna useful for satellite communications on-the-move (SOTM) applications. The system operates in the downlink Ka band (19.7 - 20.2 GHz). It consists of a shaped dielectric lens fed by a circularly polarized (CP) patch antenna. The lens system allows a mechanical beam steering from 0° to 57° in relation to the zenith, with a scan loss below of 4.5 dB. A comparison is provided between this system and a previous one using the same lens but fed by a horn antenna, demonstrating the potential of planar structures as low profile feeders for SOTM lens antennas.
Morphological approach of stereo camera based human motion capture system

This paper presents a new real-time system to acquire motion information of human articulated objects such as arm and head. The system does not need any marker or device to wear on human body and adopted stereo camera to obtain robust system against for illumination and complex background without position initialization of articulated objects. We present a solution to estimate self-occluded body objects when human model behaves normal action towards the camera. The main idea of the solution is to apply a component labeling techniques on sliced disparity map, and found the arm position when the arm is located in front of basis distance of body and we could also found arm location when the arm is located on the basis distance with Morphological methods. From this approach we can obtain the full body shape considering self-occlusion. It is simple and fast in comparison with other methods which satisfy real-time performance and accuracy of object tracking at the same time. As the result of experiments, we obtained the reliable motion data of articulated object motion under various costume and body type of models.
Complex dynamics in academics' developmental processes in teaching

Improving teaching in higher education is a concern for universities worldwide. This study explored academics’ developmental processes in teaching using episodic interviews and teaching portfolios. Eight academics in the context of teaching development reported changes in their teaching and change triggers. Thematic analyses revealed seven areas of change: participants most frequently reported changes in concepts about teaching, their teaching selves and teaching strategies. Triggers of change clustered into eight categories with teaching practices, teaching courses and metacognition reported most frequently. Analysing relations among areas and triggers of change indicated complex dynamics in academics' developmental processes in teaching. This suggests that teaching development should incorporate multiple change triggers to facilitate academics' development in teaching effectively.
Association between body iron stores and the risk of acute myocardial infarction in men.

BACKGROUND Epidemiological evidence concerning the role of iron, a lipid peroxidation catalyst, in coronary heart disease (CHD) is inconsistent. We investigated the association of the concentration ratio of serum transferrin receptor to serum ferritin (TfR/ferritin), a state-of-the-art measurement of body iron stores, with the risk of acute myocardial infarction (AMI) in a prospective nested case-control study in men from eastern Finland. METHODS AND RESULTS Transferrin receptor assays were carried out for 99 men who had an AMI during an average 6.4 years of follow-up and 98 control men. Both the cases and the controls were nested from the Kuopio Ischemic Heart Disease Risk Factor Study (KIHD) cohort of 1931 men who had no clinical CHD at the baseline study. The controls were matched for age, examination year, and residence. AMIs were registered prospectively. Soluble transferrin receptors were measured by immunoenzymometric assay and ferritin concentration by radioimmunoassay from frozen baseline serum samples. The mean TfR/ferritin ratio was 15.1 (SE, 2.0) among cases and 21.3 (SE, 2.2) among controls (P=.035 for difference). In logistic regression models adjusting for other strongest risk factors for AMI and indicators of inflammation and alcohol intake, men in the lowest and second lowest thirds of the TfR/ferritin ratio had a 2.9-fold (95% CI, 1.3 to 6.6, P=.011) and 2.0-fold (0.9 to 4.2, P=.081) risk of AMI compared with men in the highest third (P=.010 for trend). CONCLUSIONS These data show an association between increased body iron stores and excess risk of AMI, confirming previous epidemiological findings.
Targeted therapies in rheumatoid arthritis

De laatste jaren is veel vooruitgang geboekt bij de behandeling van reumatoide artritis (RA), maar nog steeds bestaat de behoefte huidige therapieen te optimaliseren en nieuwe behandelmethodes te ontwikkelen. Maartje Boumans onderzocht de anti-B-celtherapie rituximab om meer te weten te komen over het werkingsmechanisme van dit medicijn en om het doseerschema te optimaliseren. Ook voerde ze gerandomiseerde, placebo-gecontroleerde onderzoeken uit waarin ze twee nieuwe mogelijkheden onderzocht voor de behandeling van RA: remming van het eiwit osteopontine en remming van de vorming van interleukine-12 en -23. Beide behandelingen leken onvoldoende effect te hebben vergeleken met de placebogroep.
Worlds of Welfare Capitalism and Wellbeing: A Multilevel Analysis

Abstract Social scientists in the comparative policy tradition have long argued that welfare systems in modern capitalist societies can be broken down into ideal types. The idea of different worlds of welfare capitalism has an enduring appeal and growing practical policy relevance as governments seek to enhance population wellbeing. In this paper, we explore the worlds of welfare theory from the perspective of happiness. Drawing on data from the World Values Survey, we examine how welfare regimes may contribute to wellbeing and we consider the significance of our findings for the development of social policy. By using multilevel models, it is possible to separate out effects due to observed and unobserved, as well as both individual-level and country-level, welfare state characteristics and we can make inferences to the distribution of social wellbeing across welfare typologies. We find that respondents living in liberal and conservative countries experience at least twice the odds of unhappiness of those living in social democracies, after controlling for individual- and country-level explanatory variables. The observed differences between the worlds of welfare were found to be highly statistically significant.
Kinetics of Branchial Calcium Uptake in the Rainbow Trout: Effects of Acclimation to Various External Calcium Levels

Calcium uptake (J Ca in ) in freshwater rainbow trout ( Salmo gairdnen ) under control conditions (external [Ca 2+ ] ≃ 1.8 mequivl −1 , [NaCl] ≃ 0.8 mequiv 1 −1 ) occurred at approximately equal rates (12–15 μequiv kg −1 h −1 ) through the gills and the general body surface in vivo . The gut was not involved. Under the same conditions, in vitro branchial J Ca in in an isolated, saline-perfused head preparation was equal to that in vivo . The cells involved in J in Ca are mainly located on lamellae rather than on filaments since 95 % of J in Ca occurred across the arterio-arterial circulation of the gill. J in Ca , in vitro, displayed Michaelis-Menten kinetics. Acclimation to low external [Ca 2+ ] (50 μequiv 1 −1 ; unchanged [NaCl]) for 1 day caused a five-fold stimulation of J in Ca characterized by decreased K m and increased J max . Longer periods of low [Ca 2+ ] acclimation resulted in changes of J max only. J max gradually returned towards control levels as acclimation time increased, but was still elevated after 30 days. Acclimation to low ambient [Ca 2+ ] caused proliferation and increased exposure of lamellar chloride cells which were correlated with increased J max . Fish exposed to high external [Ca 2+ ] (10 mequivl −1 ; unchanged [NaCl]) displayed reduced J in Ca Similar changes in J in Ca were observed during in vivo experiments. Plasma Ca 2+ concentration remained constant regardless of external [Ca 2+ ], while plasma Na + and Cl − levels were transiently reduced at 1 day low [Ca 2+ ] exposure but had recovered by 7 days. A possible role for cortisol in Ca 2+ regulation is discussed based on observations of cortisol-stimulated lamellar chloride cell proliferation and J in Ca , and elevated plasma [cortisol] in low-[Ca 2+ ] acclimated fish.
Preparation of adult patients for anaesthesia and surgery

Although the experience of a surgical and anaesthesiological procedure is unique to every patient, many preoperative events and routines will to a certain extent be shared by a majority of patients. This review will be limited to this area of routine preoperative care and evaluation, as applied to and by the anaesthesia team before elective surgery. The word “routine” is used more in the sense of what is most commonly done; the notion of a mechanically performed act is totally inappropriate and dangerous in this context.
Visual attention in mixed-gender groups

A basic principle of objectification theory is that a mere glance from a stranger represents the potential to be sexualized, triggering women to take on the perspective of others and become vigilant to their appearance. However, research has yet to document gendered gaze patterns in social groups. The present study examined visual attention in groups of varying gender composition to understand how gender and minority status influence gaze behavior. One hundred undergraduates enrolled in psychology courses were photographed, and an additional 76 participants viewed groupings of these photographs while their point of gaze was recorded using a remote eye-tracking device. Participants were not told that their gaze was being recorded. Women were viewed more frequently and for longer periods of time than men in mixed-gender groups. Women were also more likely to be looked at first and last by observers. Men spent more time attending to pictures of women when fewer women were in the group. The opposite effect was found for pictures of men, such that male pictures were viewed less when fewer pictures of men were in the group. Female observers spent more time looking at men compared to male observers, and male observers spent more time looking at women than female observers, though both female and male observers looked at women more than men overall. Consistent with objectification theory, women's appearance garners more attention and interest in mixed-gender social groups.
Whose evidence do we follow?

Evidence-based medicine (EBM) is the cornerstone of current medical practice and education. [1] From its beginnings in the early 20th century, modern medicine grew on the basis of knowledge passed on by eminent practitioners, at times based purely on anecdotes and logic. But then, who would need a randomized trial to know that parachutes save lives? Some of the discoveries were so radical that to question them, or their innovators, would be blasphemous. The use of anesthesia, antisepsis, antibiotics, radical surgery for cancer, and chemotherapy delivered results that were so obviously superior to previous practice that they were rapidly adopted and disseminated. Over the last 30 years, the impact of new discoveries became progressively smaller. A new drug would provide improvement in 10% of patients and improve survival by 3 months, and a surgical technique would decrease hospital stay by 12 h. Along with smaller benefits came the growth of commerce and enterprise where each new discovery promised billions of dollars to its owners if it succeeded. Conflicting reports on outcomes with high‐profile endorsements created an environment of uncertainty where EBM provided a solution.
Cell cycle-dependent regulation of RNA polymerase I transcription: the nucleolar transcription factor UBF is inactive in mitosis and early G1.

Transcription of ribosomal RNA genes by RNA polymerase (pol) I oscillates during the cell cycle, being maximal in S and G2 phase, repressed during mitosis, and gradually recovering during G1 progression. We have shown that transcription initiation factor (TIF)-IB/SL1 is inactivated during mitosis by cdc2/cyclin B-directed phosphorylation of TAFI110. In this study, we have monitored reactivation of transcription after exit from mitosis. We demonstrate that the pol I factor UBF is also inactivated by phosphorylation but recovers with different kinetics than TIF-IB/SL1. Whereas TIF-IB/SL1 activity is rapidly regained on entry into G1, UBF is reactivated later in G1, concomitant with the onset of pol I transcription. Repression of pol I transcription in mitosis and early G1 can be reproduced with either extracts from cells synchronized in M or G1 phase or with purified TIF-IB/SL1 and UBF isolated in the presence of phosphatase inhibitors. The results suggest that two basal transcription factors, e.g., TIF-IB/SL1 and UBF, are inactivated at mitosis and reactivated by dephosphorylation at the exit from mitosis and during G1 progression, respectively.
Construct validity of the demand-control model: A double cross-validation approach

Abstract According to Karasek's demand-control model, negative work- and health-related outcomes are espccially likely to occur when job demands are high and a worker's control over the job is low. Many studies have examined this hypothesis, but no consistent supportive evidence has been found. The current paper reviews earlier studies and critiques, and focuses on the internal and external validity of the demand-control model as it is usually understood. In a first study the factorial structure of the model was examined. Confirmatory factor analyses of data from two samples (n = 179 and 302, respectively) demonstrated that a three-factor model (with factors Skill Discretion, Decision Authority and Psychological Job Demands) fitted the data best. In a second study using the same samples the authors examined how these three factors were related to a range of health- and work-related outcome variables. The interaction hypothesis suggested by Karasek was not supported, but the authors did find main effects o.
Clinimetrics Corner: The Minimal Clinically Important Change Score (MCID): A Necessary Pretense

Abstract Minimal clinically important differences (MCID) are patient derived scores that reflect changes in a clinical intervention that are meaningful for the patient. At present, there are a number of different methods to obtain an MCID, as there a number of different factors that can influence the MCID value. This clinimetric corner outlines the hidden challenges associated with identifying a viable MCID and possible suggestions to improve the future development of these single scores.
Quality of warfarin control in atrial fibrillation patients in South East Queensland, Australia

Warfarin is widely prescribed to decrease the risk of stroke in atrial fibrillation (AF) patients. Due to patient variability in response, regular monitoring is required, and time in therapeutic range (TTR) used to indicate quality of warfarin control with a TTR>60% is recommended. Recently, an Australian Government review of anticoagulants identified the need to establish current warfarin control and determine the potential place of the newer oral anticoagulants.