Miracle-dz/UniFAR-FTUs huggingface dataset:
The promise of novel treatments for severe chronic neutropenia

ABSTRACT Introduction Severe chronic neutropenia, i.e. absolute neutrophil count (ANC) less than 0.5 × 109/L, is a serious health problem because it predisposes patients to recurrent bacterial infections. Management radically changed with the discovery that granulocyte colony-stimulating factor (G-CSF) could be used to effectively treat most patients; therapy required regular subcutaneous injections. In the early days of G-CSF therapy, there were concerns that it might somehow overstimulate the bone marrow and cause myelodysplasia (MDS) or acute myeloid leukemia (AML). Detailed research records from the Severe Chronic Neutropenia International Registry (SCNIR) indicate that this is a relatively low-risk event. The research records suggest that certain patient groups are primarily at risk. Presently, allogeneic hematopoietic stem cell therapy serves as an alternate form of therapy. Areas Covered Due to these concerns and the desire for an easy-to-take oral alternative, several new treatments are under investigation. These treatments include neutrophil elastase inhibitors, SGLT-2 inhibitors, mavorixafor – an oral CXCR4 inhibitor, gene therapy, and gene editing. Expert Opinion All of these alternatives to G-CSF are promising. The risks, relative benefits, and costs are yet to be determined.
Derivation of direct on‐fault submarine paleoearthquake records from high‐resolution seismic reflection profiles: Wairau Fault, New Zealand

Direct, on‐fault submarine paleoearthquake records can be derived from high‐resolution seismic reflection profiles of active fault growth sequences. Coseismic vertical increments of displacement are best preserved in the architecture of the growth sequence when the long‐term rate of sedimentation exceeds the rate of fault vertical displacement. Postseismic stratigraphic intervals can be recognized on vertical displacement history curves, from which estimates of the earthquake timing and vertical displacements can be made. The strike‐slip Wairau Fault is a major seismic hazard in central New Zealand and is partially submarine. Analysis of 10 high‐resolution seismic profiles spanning a 20 km section of the offshore fault trace reveals two types of postseismic growth sequences and a composite paleoearthquake record with up to eight surface‐rupturing earthquakes since 18 ka. The recurrence intervals range from ∼0.9 to 3.8 ka (mean is ∼2.2 ka), while the coseismic vertical displacements range from 0.5 to 5.3 m (mean is ∼2.5 m). These data conform to the variable slip model of earthquake behavior. The vertical coseismic displacement is not always predictable from the recurrence interval preceding the event. The data indicate that the seismic moment release has not been constant between earthquakes or that the ratio of horizontal to vertical coseismic displacement at a given site has varied over multiple earthquake cycles. The offshore data are consistent with onshore paleoearthquake records, long‐term dextral slip rate of >2 mm/yr (compared to 3–5 mm/yr, 40 km in land), and paleoearthquakes of >Mw 7.5. The last earthquake occurred on the fault 2.0 ± 0.3 kyr ago, indicating that significant elastic strain has now accrued.
Future Frontiers: Exploration of practices, challenges, and educational needs of genetic counselors in emerging subspecialties

The augmented use of genomic testing across different medical subspecialties has led to increased involvement of genetic counselors (GCs) in specialized areas of medicine. However, the lack of educational infrastructure required for changing scholastic needs of GCs entering new subspecialties lends to the burden of self‐directed learning and inconsistent knowledge. We conducted a cross‐sectional study surveying GCs with experience in the emerging genetic subspecialties of Immunology, Dermatology, Endocrinology, and Pulmonology (abbreviated as “IDEP”) on current practices, clinical challenges, and educational strategies undertaken while working in these settings. We compared knowledge and confidence in skills related to IDEP patient care between GCs who do (experienced cohort) and do not (control cohort) practice in these settings to assess their comfort with working in subspecialties. Participants were recruited from the National Society of Genetic Counselors membership. A total of 304 GCs (178 experienced and 126 control) completed the survey. Most GCs in the experienced cohort saw IDEP patients by themselves (n = 104; 58.4%) or with a geneticist (n = 97; 54.4%) and almost all (n = 176; 99%) cited GeneReviews as a primary informational source for IDEP genetics but half (n = 91; 51.1%) agreed that a dedicated online course would be the best way to learn about a specific subspecialty. The experienced cohort scored higher on confidence in all skills (p < 0.001, z = 7.32) and knowledge (p < 0.001, z = 5.68) related to IDEP genetics than the control cohort. Previous exposure to IDEP through graduate school coursework and rotations positively correlated with better self‐confidence in skills (p = 0.02, z = −2.19; p < 0.001, z = −5.25) and genetic knowledge (p = 0.03, z = −2.09; p < 0.001, z = −2.81) related to IDEP patient care. Years of experience working as a GC did not correlate with better confidence in skills (p = 0.53) or better IDEP genetic knowledge (p = 0.15). Our findings show that provision of opportunities for increased exposure to subspecialties could help maximize GCs' ability to work in emerging niche fields.
Global distribution of soil phosphorus retention potential

Limited availability of P in soils to crops may be due to deficiency and/or severe P retention. Earlier studies that drew on large soil profile databases have indicated that it is not (yet) feasible to present meaningful values for “plant-available” soil P, obtained according to comparable analytical methods, that may be linked to soil geographical databases derived from 1:5 million scale FAO Digital Soil Map of the World, such as the 5 x 5 arc-minute version of the ISRIC-WISE database. Therefore, an alternative solution for studying possible crop responses to fertilizer-P applied to soils, at a broad scale, was sought. The approach described in this report considers the inherent capacity of soils to retain phosphorus (P retention), in various forms. Main controlling factors of P retention processes, at the broad scale under consideration, are considered to be pH, soil mineralogy, and clay content. First, derived values for these properties were used to rate the inferred capacity for P retention of the component soil units of each map unit (or grid cell) using four classes (i.e., Low, Moderate, High, and Very High). Subsequently, the overall soil phosphorus retention potential was assessed for each mapping unit, taking into account the P-ratings and relative proportion of each component soil unit. Each P retention class has been assigned to a likely fertilizer P recovery fraction, derived from the literature, thereby permitting spatially more detailed, integrated model-based studies of environmental sustainability and agricultural production at the global and continental level (< 1:5 million). Nonetheless, uncertainties remain high; the present analysis provides an approximation of world soil phosphorus retention potential.
Disseminating cells in human oral tumours possess an EMT cancer stem cell marker profile that is predictive of metastasis in image-based machine learning

Cancer stem cells (CSCs) undergo epithelial-mesenchymal transition (EMT) to drive metastatic dissemination in experimental cancer models. However, tumour cells undergoing EMT have not been observed disseminating into the tissue surrounding human tumour specimens, leaving the relevance to human cancer uncertain. We have previously identified both EpCAM and CD24 as CSC markers that, alongside the mesenchymal marker Vimentin, identify EMT CSCs in human oral cancer cell lines. This afforded the opportunity to investigate whether the combination of these three markers can identify disseminating EMT CSCs in actual human tumours. Examining disseminating tumour cells in over 12,000 imaging fields from 74 human oral tumours, we see a significant enrichment of EpCAM, CD24 and Vimentin co-stained cells disseminating beyond the tumour body in metastatic specimens. Through training an artificial neural network, these predict metastasis with high accuracy (cross-validated accuracy of 87–89%). In this study, we have observed single disseminating EMT CSCs in human oral cancer specimens, and these are highly predictive of metastatic disease.
Modeling of carbon dioxide transport and production in soil: 2. Parameter selection, sensitivity analysis, and comparison of model predictions to field data

In paper 1 of this two-paper series (Simůnek and Suarez, this issue) we presented a description of the numerical model, SOILCO2, for CO2 transport and production in the unsaturated zone. In paper 2 the model sensitivity to various parameters is evaluated by both steady state and transient simulations, with a range in the parameter values typically found under field conditions. We also select parameter values for optimal plant and microbial CO2 production and production dependence on temperature, water content, osmotic potential and gas composition for plant and microbial respiration, all based on literature review. The predictive capabilities of the SOILCO2 model are evaluated by comparing model simulations to published field data from Missouri for three different crops and two growing seasons under transient conditions as well as a data set collected in Riverside, California, under relatively constant water content at depth. The model provided good prediction of the CO2 flux to the atmosphere as well as the concentrations in the root zone for all data sets.
The Hansenula polymorpha Mitochondrial Carrier Family proteins Mir1 and Aac2 are dually localized at peroxisomes and mitochondria

Peroxisomes are ubiquitous cell organelles involved in various metabolic pathways. In order to properly function, several cofactors, substrates and products of peroxisomal enzymes need to pass the organellar membrane. So far only a few transporter proteins have been identified. We analysed peroxisomal membrane fractions purified from the yeast Hansenula polymorpha by untargeted label-free quantitation mass spectrometry. As expected, several known peroxisome-associated proteins were enriched in the peroxisomal membrane fraction. In addition, several other proteins were enriched, including mitochondrial transport proteins. Localization studies revealed that two of them, the mitochondrial carrier family proteins Aac2 and Mir1, have a dual localization on mitochondria and peroxisomes. To better understand the molecular mechanisms of dual sorting, we tested the localization of Mir1 in cells lacking Pex3 or Pex19, two peroxins that play a role in targeting of peroxisomal membrane proteins. In these cells Mir1 only localized to mitochondria, indicating that Pex3 and Pex19 are required to sort Mir1 to peroxisomes. Analysis of the localization of various truncated versions of Mir1 in wild-type H. polymorpha cells revealed that several localized to mitochondria, but only one, consisting of the transmembrane domains 3-6, was peroxisomal. Peroxisomal localization of this construct was lost in a MIR1 deletion strain, indicating that full length Mir1 was required for the localization of the truncated protein to peroxisomes. Our data suggest that only full length Mir1 sorts to peroxisomes, while Mir1 contains multiple regions with mitochondrial sorting information.
Relationship between Purpose in Life and Death Anxiety among Elderly Home Residents

: Death anxiety is a concept used to indicate concern about death awareness. The loss of purpose in life can lead to an existential vacuum that can lead to death anxiety. Aim: to determine relationship between purpose in life and death anxiety among elderly home residents. Design: A descriptive correlational research design was used. Subjects: 66 out of 99 elderly persons residents in governmental elderly home in Dakahlia governorate, in Tanta city and in Ras El-Bar city were included in the study. Tools: Mini Mental State Examination, Purpose in Life test, Death anxiety scale, Socio-demographic & clinical data structured interview schedule were used to collect the data. Results: Sixty percent of the elderly home residents had a definite purpose in life and 72.7% had low death anxiety. Also there was negative significant correlation between purpose in life and death anxiety among residents of elderly homes r = -0.48. Conclusion: purpose in life was inversely correlated with death anxiety among elderly home residents. Recommendations: Encouraging elderly people to participate in social activity that foster purpose in life.
Modes of Knowing

How might we think differently? This book is an attempt to respond to this question. Its contributors are all interested in non-standard modes of knowing. They are all more or less uneasy with the restrictions or the agendas implied by academic modes of knowing, and they have chosen to do this by working with, through, or against one important Western alternative - that of the baroque. Why the baroque? One answer is that the baroque made space for and fostered many forms of otherness. It involved knowing things differently, extravagantly, excessively, and in materially heterogeneous ways, and it apprehended that which is other and could not be caught in a cognitive or symbolic net. It also involved knowing in ways that did not gather into a single point and knew itself to be performative. As part of a great Western division between rationalist and non-rationalist modes of knowing, the baroque is therefore a possible resource for creating ways of knowing differently - a storehouse of possible alternative techniques. To say this is not to say that it is the right mode of knowing. The book's authors do not seek to create a 'baroque social science' whatever that might be, but instead work in a range of ways to explore how drawing on the 'resources of the baroque' can help us to think differently.
. Systematic study on incidence and characterization of

Present research was planned to study incidence, virulence factors viz. biofilm and coagulase production and antibiogram of Staphylococcus aureus associated with bovine mastitis. Milk samples (142) of clinical and subclinical bovine mastitis cases from Mumbai and around Mumbai region were processed. From the milk samples processed; 52 (36.61%) Staphylococcus spp. isolates were recovered. Incidence of S. aureus in bovine mastitis was 28.16% (in cows: 41.37% and in buffaloes: 24.77%). The incidence rate of S. aureus in subclinical and clinical mastitis was 17.24% and 30.97% respectively. The results of antibiotic resistance pattern of isolates indicated highest resistance to penicillin (100%) followed by vancomycin and oxacillin (77.5%) and gentamicin (15%). The least resistance was observed to chloramphenicol (12.5%), ceftriaxone (10%), methicillin and cephotaxim (7.5%). Out of 40 S. aureus isolates characterized for biofilm production , overall 32 (80%) isolates were biofilm producing which were confirmed using various methods, viz. CRA (45%), TCP (35%) and PCR (72.5%) of intercellular adhesin gene ica A and ica D. Of 32 biofilm producing S. aureus, 20 (62.50%) were coagulase producing strains and 65.62% of them also showed biofilm production. Out of 40 S. aureus isolates, 26 (65.00 %) were proved to be coagulase producing strains by tube method; whereas by coa PCR assay, 21 (52.5%) isolates showed presence of coagulase gene. Out of 21 coa exhibiting strains of S. aureus, 4 (10%) isolates were of coa genotype A with an amplicon size of 850 bp while 17 (42.5%) S. aureus isolates were of genotype B with an amplicon product of 600 bp. Out of 26 coagulase producing S. aureus, 21 (80.76%) were biofilm producing. Most of biofilm and coagulase producing strains displayed multiple drug resistant.
Diffusion curves: a vector representation for smooth-shaded images

We describe a new vector-based primitive for creating smooth-shaded images, called the diffusion curve. A diffusion curve partitions the space through which it is drawn, defining different colors on either side. These colors may vary smoothly along the curve. In addition, the sharpness of the color transition from one side of the curve to the other can be controlled. Given a set of diffusion curves, the final image is constructed by solving a Poisson equation whose constraints are specified by the set of gradients across all diffusion curves. Like all vector-based primitives, diffusion curves conveniently support a variety of operations, including geometry-based editing, keyframe animation, and ready stylization. Moreover, their representation is compact and inherently resolution independent. We describe a GPU-based implementation for rendering images defined by a set of diffusion curves in real time. We then demonstrate an interactive drawing system for allowing artists to create artworks using diffusion curves, either by drawing the curves in a freehand style, or by tracing existing imagery. Furthermore, we describe a completely automatic conversion process for taking an image and turning it into a set of diffusion curves that closely approximate the original image content.
Observation of the B+ -> D*K--(+) pi(+) decay

The B þ → D (cid:1) − K þ π þ decay potentially provides an excellent way to investigate charm meson spectroscopy. The decay is searched for in a sample of proton-proton collision data collected with the LHCb detector at center-of-mass energies of 7 and 8 TeV, corresponding to an integrated luminosity of 3 fb − 1 . A clear signal is observed, and the ratio of its branching fraction to that of the B þ → D (cid:1) − π þ π þ normalization channel is measured to be B ð B þ → D (cid:1) − K þ
EMPLOYEE WORK MEANINGLESSNESS AND DEVIANT BEHAVIOUR IN FOUR-STAR HOTELS IN THE SOUTH-SOUTH REGION OF NIGERIA

: Workers’ behaviour towards their given task or job as well as their organization is a very important tool to any organization to attaining set objectives and improving performance, thus, the aim of this paper is to examine the relationship between employee work meaninglessness and deviant bevaiour (production deviance, property deviance, political deviance and personal aggression as its measures) of four star hotels in the south-south region of Nigeria. A cross sectional survey research design was adopted to examine the relationship between the study variables while the unit of analysis was at the micro level that is employees of the studied hotels. Furthermore, from the study population of 982 employees in the four star hotels in the region, 274 sample size was gotten using the Krejcie and Morgan sample size determination formula while questionnaire was used as the research instrument to collect data and out of the 274 questionnaire distributed, 223 were useful for data analysis. The data collected was analyzed using spearman’s rank order correlation coefficient with the aid of Statistical Package for Social Sciences. Our findings revealed that meaninglessness significantly affects deviant behaviour of the studied hotels. We therefore recommends that Managers of the four-star hotels should concentrate on employee behaviour in the organization by creating policies that can enhance employee values, freedom, innovation, development, and self-improvement.
Search for nonpointing photons in the diphoton and E miss T state in proton-proton collisions using the ATLAS detector

A search has been performed for photons originating in the decay of a neutral long-lived particle, exploiting the capabilities of the ATLAS electromagnetic calorimeter to make precise measurements of the ﬂight direction of photons, as well as the calorimeter’s excellent time resolution. The search has been made in the diphoton plus missing transverse energy ﬁnal state, using the full data sample of 4 : 8 fb (cid:1) 1 of 7 TeV proton-proton collisions collected in 2011 with the ATLAS detector at the LHC. No excess is observed above the background expected from Standard Model processes. The results are used to set exclusion limits in the context of gauge mediated supersymmetry breaking models, with the lightest neutralino being the next-to-lightest supersymmetric particle and decaying with a lifetime in excess of 0.25 ns into a photon and a gravitino.
Relationship between Obesity and Maternal Psychological Status of Pregnant Women

: Several studies have shown that obese women are more vulnerable to the development of psychiatric and psychological disorders. Additionally maternal psychosocial stress during pregnancy is associated with risks to maternal health and birth outcomes, and health and behavioral outcomes in offspring. The study aimed to investigate the relationship between obesity and maternal psychological status of pregnant women. This study followed a comparative descriptive design. The study was conducted at antenatal clinic at Tanta University Hospital, The target population include 100 normal pregnant and 100 pregnant obese women who attend at antenatal clinic for receiving antenatal care, Four tools used to collect data for the study, tool I ; Socio-demographic characteristics of the women, tool 2 ;Perceived Anxiety ( HAM-A), Tool 3; Perceived Stress Scale, Tool 4: General Health Questionnaire (GHQ-12). Results of the study indicated that there was a statistically significant difference between normal pregnant women and obese pregnant women at p-value =0.001 in their experience of anxiety during their pregnancy, and in their experience of stress in at p-value =0.003. Also there was a statistically significant relationship between the effect of income on normal pregnant women and obese pregnant women in their experience of anxiety at p-value =0.006 and at p-value =0.044. It was concluded that the obese or normal weight pregnant women with low education, low income, and had no job were more likely to experience severe levels of stress and anxiety, which has more complication for them. The study recommended that a combination of health education with psychological interventions is more effective than information alone to produce significant behavior change.
EMIGRAM A SHARED IDENTITY APP FOR MIGRANTS

The global phenomenon of migration, forced displacement, and the refugee crisis is increasingly impacting individuals and communities worldwide. Within this context, refugees and migrants encounter distinct challenges during their relocation to new countries, as they are separated from their social networks, close relationships, and familiar cultural environments. Consequently, they undergo temporary social isolation while adapting to unfamiliar cultural contexts, leading to higher risks of homesickness, diminished well-being, and feelings of loneliness.