Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-Term Potentiation Enhances Neuronal Differentiation in the Chronic Hypoperfusion Model of Rats

Several reports have shown that long-term potentiation (LTP) per se effectively enhances neurogenesis in the hippocampus of intact animals. If LTP can enhance neurogenesis in chronic hypoperfusion, this approach could potentially become a new therapeutic strategy for the restoration of cognitive function and for prevention from deterioration of mild cognitive impairment (MCI). Using an in vivo LTP model of rats, we examined whether LTP per se can enhance neurogenesis in hypoperfusion rats that underwent permanent bilateral common carotid artery occlusion (permanent 2-vessel occlusion, P2VO). High frequency stimulation (HFS) in the subacute phase after P2VO enhanced hippocampal cell proliferation and neurogenesis. However, most enhanced cell proliferation and neurogenesis was seen in the hypoperfusion rats that received HFS and for which LTP could finally be induced. In contrast, the same effect was not seen in the LTP induction in the chronic phase. The present findings, which reveal that most enhanced neurogenesis was seen in hypoperfusion rats for which LTP could be finally induced, could explain the ability of LTP-like activities such as learning paradigms and environmental stimuli to increase the rate of neurogenesis in the hippocampus even under hypoperfusion conditions. Moreover, the present findings, which reveal that LTP induction in the chronic phase after P2VO could not effectively enhance neurogenesis in the hypoperfusion rats, could indicate that patients with MCI and even middle-aged healthy control individuals should start LTP-like activities as early as possible and continue with these activities to prevent age-related deterioration of hippocampal function.
Genetic diversity and demographic history of the giant river catfish Sperata seenghala inferred from mitochondrial DNA markers

Abstract The giant river catfish Sperata seenghala has huge demand in South Asian countries due to its low number of intramuscular bones and nutritive value. However, the culture practises for this fish have not been standardized and the current demand for this fish is being met by capture fisheries only. Unregulated and indiscriminate fishing would lead overexploitation of fish stocks subsequently stock depletion. Genetic diversity between populations would give insight about population structure and demography. In the present study, S. seenghala stocks from three rivers, namely Ganga, Brahmaputra and Mahanadi were characterized using cytochrome b gene and D-loop region. Moderate to high haplotype diversity and low nucleotide diversity values were observed in all populations. Analysis of molecular variance and pairwise FST values showed significant genetic differentiation among populations. Patterns of diversity, haplotype networks and mismatch distribution strongly suggest a historical influence on the genetic structure of S. seenghala populations. S. seenghala stocks from these three rivers are genetically distinct units and management measures should be formulated separately for each population.
Comparison Between Segregation of High‐Manganese Steels from 2‐D Phase‐Field Simulations, 1‐D Analytical Theories, and Solidification Experiments

This paper presents a study comparing the microsegregation from 2‐D phase‐field simulations with those predicted by 1‐D analytical theories and with the ones obtained from experiments. It focuses mainly on the solidification of an Fe–Mn binary alloy with high manganese content (23 wt%), which is comparable to the manganese content of high‐manganese steel (HMnS) grades. The main motivation for this study comes from the strong influence of microsegregation on the local mechanical properties of these steels at room temperature. After performing simulations with the model for different realistic cooling rates, the secondary dendrite arm spacings, which are strongly related to the microsegregation phenomenon, are determined and compared with an analytical model and also with experimental results from the literature for similar alloys. Analyses of concentration of the simulated samples, which are related with real microsegregation phenomenon, are also presented in this investigation using an area‐based frequency distribution. The distribution results from simulations are also compared to the 1‐D analytical Brody–Flemings model, to a DICTRA simulation, and to experimental results for a similar alloy. From this investigation, it is concluded that the concentration distribution for binary alloy simulations in 2‐D agrees semi‐quantitatively with the experimental results for ternary alloys.
Resting and Postexercise Heart Rate Detection From Fingertip and Facial Photoplethysmography Using a Smartphone Camera: A Validation Study

Background Modern smartphones allow measurement of heart rate (HR) by detecting pulsatile photoplethysmographic (PPG) signals with built-in cameras from the fingertips or the face, without physical contact, by extracting subtle beat-to-beat variations of skin color. Objective The objective of our study was to evaluate the accuracy of HR measurements at rest and after exercise using a smartphone-based PPG detection app. Methods A total of 40 healthy participants (20 men; mean age 24.7, SD 5.2 years; von Luschan skin color range 14-27) underwent treadmill exercise using the Bruce protocol. We recorded simultaneous PPG signals for each participant by having them (1) facing the front camera and (2) placing their index fingertip over an iPhone’s back camera. We analyzed the PPG signals from the Cardiio-Heart Rate Monitor + 7 Minute Workout (Cardiio) smartphone app for HR measurements compared with a continuous 12-lead electrocardiogram (ECG) as the reference. Recordings of 20 seconds’ duration each were acquired at rest, and immediately after moderate- (50%-70% maximum HR) and vigorous- (70%-85% maximum HR) intensity exercise, and repeated successively until return to resting HR. We used Bland-Altman plots to examine agreement between ECG and PPG-estimated HR. The accuracy criterion was root mean square error (RMSE) ≤5 beats/min or ≤10%, whichever was greater, according to the American National Standards Institute/Association for the Advancement of Medical Instrumentation EC-13 standard. Results We analyzed a total of 631 fingertip and 626 facial PPG measurements. Fingertip PPG-estimated HRs were strongly correlated with resting ECG HR (r=.997, RMSE=1.03 beats/min or 1.40%), postmoderate-intensity exercise (r=.994, RMSE=2.15 beats/min or 2.53%), and postvigorous-intensity exercise HR (r=.995, RMSE=2.01 beats/min or 1.93%). The correlation of facial PPG-estimated HR was stronger with resting ECG HR (r=.997, RMSE=1.02 beats/min or 1.44%) than with postmoderate-intensity exercise (r=.982, RMSE=3.68 beats/min or 4.11%) or with postvigorous-intensity exercise (r=.980, RMSE=3.84 beats/min or 3.73%). Bland-Altman plots showed better agreement between ECG and fingertip PPG-estimated HR than between ECG and facial PPG-estimated HR. Conclusions We found that HR detection by the Cardiio smartphone app was accurate at rest and after moderate- and vigorous-intensity exercise in a healthy young adult sample. Contact-free facial PPG detection is more convenient but is less accurate than finger PPG due to body motion after exercise.
The effect of hardiness on symptoms of insomnia during a naval mission.

BACKGROUND Sleep is increasingly being recognised as important for the health and well-being of sailors. The aim of the current study is to investigate the relationship between hardiness and reported insomnia-symptoms in a maritime military setting during a 4-month counter piracy naval mission in the Gulf of Aden. MATERIALS AND METHODS A sample of 281 officers, sailors, and enlisted personnel were measured on levels of hardiness before the mission. The participants were split into low and high hardiness groups based on the group level mean. Insomnia-symptoms were measured before, midway and at the end of the mission. RESULTS The results showed a significant main effect of time and a significant main effect of hardiness. The crew experienced the most insomnia symptoms in the middle of the mission and the high hardy group experienced less insomnia symptoms, in total, during the mission. There was also found a significant interaction effect of time and hardiness. The high hardiness group experienced less insomnia symptoms before and towards the end of the mission. CONCLUSIONS The results indicate that high levels of hardiness may be a protective factor between the stressors of a naval mission and symptoms of insomnia.
Therapeutic effect of chidamide on relapsed refractory angioimmunoblastic T-cell lymphoma

Introduction: Angioimmunoblastic T-cell lymphoma (AITL) is a kind of rare peripheral T cell lymphoma, which usually has acute onset at old age. Materials and methods: Here we report a case of relapsed refractory AITL, which has achieved obvious curative effect after treatment with chidamide. Results: Initially, the patient received 7 courses of treatment with recombinant human endostatin (endostar)+CHOP. The patient achieved complete remission, but suffered from recurrence later. After changing chemotherapy regimens, the outcome was still not satisfactory, and the patient developed systemic skin infiltration and rashes. After 2 courses of chemotherapy with chidamide (30 mg) twice a week + intravenous injections with cyclophosphamide (0.1 g) twice every other day + thalidomide (50 mg) every night, the patient began with the oral intake of chidamide, and the therapeutic effect was satisfactory, with diminishing systemic rashes and shrunken lymph nodes. Discussion and conclusions: Chidamide has good therapeutic effect in the treatment of AITL, which provides a novel therapeutic strategy for relapsed refractory AITL. However, more cases are still needed to further validate its efficacy.
Environment determines evolutionary trajectory in a constrained phenotypic space

Constraints on phenotypic variation limit the capacity of organisms to adapt to the multiple selection pressures encountered in natural environments. To better understand evolutionary dynamics in this context, we select Escherichia coli for faster migration through a porous environment, a process which depends on both motility and growth. We find that a trade-off between swimming speed and growth rate constrains the evolution of faster migration. Evolving faster migration in rich medium results in slow growth and fast swimming, while evolution in minimal medium results in fast growth and slow swimming. In each condition parallel genomic evolution drives adaptation through different mutations. We show that the trade-off is mediated by antagonistic pleiotropy through mutations that affect negative regulation. A model of the evolutionary process shows that the genetic capacity of an organism to vary traits can qualitatively alter the evolutionary trajectory when selection pressures are complex.
Where are they now? Tracking the longitudinal evolution of environmental businesses from the 1990s

In 1991 Steven Bennett published one of the fi rst major publications on the concept of ecopreneurship, business opportunities resulting from the emerging environmental agenda of the late 1980s and early 1990s (Ecopreneuring: the Complete Guide to Small Business Opportunities From the Environmental Revolution. Wiley: New York). Since then a body of literature has developed that explores the idea of the intersection of entrepreneurship with environmentally and socially responsible behaviour. Many of the business cases presented by Bennett represent early adopters of green products, services and emerging eco-markets. Given the current emphasis on the transformation of business practices towards a more sustainable paradigm it is timely to review these 94 early ecopreneurial examples and consider their status two decades on from the original publication. This paper explores the definitions of environmental and social enterprise, and considers the longitudinal survival of these companies and the emerging trends in consolidation and failure of the sampled companies.
Tunable generation and angular steering of a millimeter-wave orbital-angular-momentum beam using differential time delays in a circular antenna array

In this paper, the generation and steering of beams carrying orbital angular momentum utilizing a custom-designed circular antenna array has been demonstrated at 28 GHz. A steering angle as large as 30 degrees for an orbital angular momentum (OAM) beam has been achieved. The effect of number of antennas and the distance from antennas to the array center to the quality of beam generation and beam steering is investigated through both experiments and simulations. Our results indicate that: (1) As the steering angle increases, the mode purity of the generated OAM beams decreases; (2) Increasing the number of antennas improves the OAM mode purity; (3) For a fixed number of antennas, high mode purity is observed for lower order OAM modes; (4) Placing the antennas farther away from the array center allows for reduced divergence of the generate OAM beams.
Aerosol-induced changes of convective cloud anvils produce strong climate warming

Abstract. The effect of aerosol on clouds poses one of the largest uncertainties in estimating the anthropogenic contribution to climate change. Small human-induced perturbations to cloud characteristics via aerosol pathways can create a change in the top-of-atmosphere radiative forcing of hundreds of Wm−2. Here we focus on links between aerosol and deep convective clouds of the Atlantic and Pacific Intertropical Convergence Zones, noting that the aerosol environment in each region is entirely different. The tops of these vertically developed clouds consisting of mostly ice can reach high levels of the atmosphere, overshooting the lower stratosphere and reaching altitudes greater than 16 km. We show a link between aerosol, clouds and the free atmosphere wind profile that can change the magnitude and sign of the overall climate radiative forcing. We find that increased aerosol loading is associated with taller cloud towers and anvils. The taller clouds reach levels of enhanced wind speeds that act to spread and thin the anvil clouds, increasing areal coverage and decreasing cloud optical depth. The radiative effect of this transition is to create a positive radiative forcing (warming) at top-of-atmosphere. Furthermore we introduce the cloud optical depth (τ), cloud height (Z) forcing space and show that underestimation of radiative forcing is likely to occur in cases of non homogenous clouds. Specifically, the mean radiative forcing of towers and anvils in the same scene can be several times greater than simply calculating the forcing from the mean cloud optical depth in the scene. Limitations of the method are discussed, alternative sources of aerosol loading are tested and meteorological variance is restricted, but the trend of taller clouds, increased and thinner anvils associated with increased aerosol loading remains robust through all the different tests and perturbations.
A dynamic‐biasing 4× charge pump based on exponential topology

A 4× charge pump using exponential topology is proposed and implemented. Comparing to the conventional implementations, the proposed circuit suppresses the reverse current effectively without using different threshold‐voltage transistors and additional capacitors. Also, the body effect found in the charge transfer switches is eliminated. The proposed charge pump is analyzed with the state‐space method and fabricated using 0.35 µm complementary metal–oxide–semiconductor process. Results show that the output voltages close to the ideal one, and a maximum power efficiency of 95% was recorded. Copyright © 2013 John Wiley & Sons, Ltd.
Red blood cells ageing markers: a multi-parametric analysis.

BACKGROUND Red blood cells collected in citrate-phosphate-dextrose can be stored for up to 42 days at 4 °C in saline-adenine-glucose-mannitol additive solution. During this controlled, but nevertheless artificial, ex vivo ageing, red blood cells accumulate lesions that can be reversible or irreversible upon transfusion. The aim of the present study is to follow several parameters reflecting cell metabolism, antioxidant defences, morphology and membrane dynamics during storage. MATERIALS AND METHODS Five erythrocyte concentrates were followed weekly during 71 days. Extracellular glucose and lactate concentrations, total antioxidant power, as well as reduced and oxidised intracellular glutathione levels were quantified. Microvesiculation, percentage of haemolysis and haematologic parameters were also evaluated. Finally, morphological changes and membrane fluctuations were recorded using label-free digital holographic microscopy. RESULTS The antioxidant power as well as the intracellular glutathione concentration first increased, reaching maximal values after one and two weeks, respectively. Irreversible morphological lesions appeared during week 5, where discocytes began to transform into transient echinocytes and finally spherocytes. At the same time, the microvesiculation and haemolysis started to rise exponentially. After six weeks (expiration date), intracellular glutathione was reduced by 25%, reflecting increasing oxidative stress. The membrane fluctuations showed decreased amplitudes during shape transition from discocytes to spherocytes. DISCUSSION Various types of lesions accumulated at different chemical and cellular levels during storage, which could impact their in vivo recovery after transfusion. A marked effect was observed after four weeks of storage, which corroborates recent clinical data. The prolonged follow-up period allowed the capture of deep storage lesions. Interestingly, and as previously described, the severity of the changes differed among donors.
High‐voltage compliant microelectrode array drivers for intracortical microstimulation

We present in this paper two low‐power high‐impedance microelectrode array drivers (MEDs) dedicated for visual intracortical microstimulation. These output stages of a new microstimulator are highly configurable and able to deliver higher compliance voltage (20 V for anodic and cathodic phases) across microelectrode‐tissue interface impedance compared with previously reported designs. Each MED is featured with a high‐voltage switch‐matrix, 3.3 V/20 V current mirrors, an on‐chip 32‐bit serial‐in parallel‐out shift register, and the new forbidden state logic circuits. Both systems are able to deliver eight bipolar or 16 monopolar stimulation simultaneously. The first MED is able to deliver one stimulation current level and the second one provides four different current amplitudes simultaneously to 16 electrodes. Two microchips have been designed and fabricated using Teledyne DALSA 0.8 µm 5V/ 20v double‐diffused metal‐oxide‐semiconductor field‐effect transistor (Teledyne DALSA Semiconductor, Bromont, Québec, Canada) technology to meet the required high‐voltage compliance. The nominal values of largest supply voltages are ±10 V. The maximum stimulation current per input channel is 400 μA and per output channel through an emulated microelectrode impedance of 100 kΩ is 100 μA. The measured output compliance voltage is 10 V/phase (anodic or cathodic) for the specified supply voltages. Increment of supply voltages to ±13 V allows 220 μA stimulation current per output channel enhancing the output compliance voltage up to 20 V/phase. The measured quiescent power consumptions of the proposed microelectrode array drivers are 316 and 735 μW, respectively. Post‐layout simulation and measurement results of two MEDs and comparison with other designs have been reported in this paper. Copyright © 2015 John Wiley & Sons, Ltd.
Assessing the Understanding of Pharmaceutical Pictograms among Cultural Minorities: The Example of Hindu Individuals Communicating in European Portuguese

One of the sources of poor health outcomes is the lack of compliance with the prescribed treatment plans, often due to communication barriers between healthcare professionals and patients. Pictograms are a form of communication that conveys meaning through its pictorial resemblance to a physical object or an action. Pharmaceutical pictograms are often associated with a better comprehension of treatment regimens, although their use is still subject to limitations. The main goal of this study was to examine the potential understanding of pharmaceutical pictograms by a cultural minority when providing patient information while comparing the effectiveness of two reference systems (United States Pharmacopeia USP and International Pharmacy Federation FIP) for this purpose. A self-administered questionnaire was developed comprising 30 pictograms, 15 selected from the United States Pharmacopeia Dispensing Information and the equivalent from the International Pharmaceutical Federation. The questionnaire comprised plain instructions, socio-demographic data, self-reported language fluency and pictogram labels in Portuguese presented to conveniently selected members of the Hindu community of Lisbon (Portugal) until reaching a quota of 50. Participants showed difficulties in understanding some pictograms, which was related to the self-reported reduced fluency in Portuguese. Overall, the interpretation of USP pictograms was better than FIP ones, as well as for pictograms composed of multiple images, presenting a negative reading, or when conveying information unrelated to medication instructions. Even using internationally validated pictograms, added care should be taken when community pharmacists use such communication resources with cultural minorities. It is important not to disregard other forms of patient communication and information, considering pictograms as a complement to other forms of patient counselling.
Climate change in cities due to global warming and urban effects

Urbanisation is estimated to result in 6 billion urban dwellers by 2050. Cities will be exposed to climate change from greenhouse gas induced radiative forcing, and localised effects from urbanisation such as the urban heat island. An urban land‐surface model has been included in the HadAM3 Global Climate Model. It shows that regions of high population growth coincide with regions of high urban heat island potential, most notably in the Middle East, the Indian sub‐continent, and East Africa. Climate change has the capacity to modify the climatic potential for urban heat islands, with increases of 30% in some locations, but a global average reduction of 6%. Warming and extreme heat events due to urbanisation and increased energy consumption are simulated to be as large as the impact of doubled CO2 in some regions, and climate change increases the disparity in extreme hot nights between rural and urban areas.
Smart distribution electrical grid for India

The smart grid is a new technology that adds efficiency to the electrical grid system. The smart distribution grid architecture proposed in this research work solves major problems faced by the Indian electrical grid such as wastage of energy by the careless usage of consumers, poor power theft and line fault detection method, and manual billing system. The intelligent devices that are placed in different parts of the distribution electrical grid together with the intelligent controlling system make the electrical grid smart.