Miracle-dz/UniFAR-FTUs huggingface dataset:
Intraoral versus extraoral cementation of implant‐supported single crowns: Clinical, biomarker, and microbiological comparisons

OBJECTIVES Implant supported single metal-ceramic crowns cemented either extraorally or intraorally were comparatively evaluated by clinical, radiologic, biomarker, and microbiological parameters. MATERIALS AND METHODS Twelve patients with bilateral single tooth gap in the maxillary posterior region received two locking-taper implants; 4.5 mm width, 8 mm length. Selection of intraoral (IOC) or extraoral cementation (EOC) using screwless titanium abutments was done randomly. Peri-implant crevicular fluid (PICF), gingival crevicular fluid (GCF) samples were collected from the implants, adjacent teeth, and bleeding on probing, soft tissue thickness, keratinized tissue width were recorded before starting the prosthetic procedures (baseline) and 3, 6 months after implant loading. Crestal bone loss was measured on radiographs taken immediately and 6 months after cementation. Cytokine levels, amounts of bacteria were determined in PICF/GCF samples. Data were tested by appropriate statistical analyses. RESULTS Clinical findings were similar in the crowns cemented extraorally or intraorally at all times (P < .05). PICF and GCF data were similar. At 3 month, interleukin-17E and osteoprotegerin levels were lower in the intraorally cemented crowns. CONCLUSION Extraorally and intraorally cemented crowns exhibited similar crestal bone loss after loading. Higher amount of osteoprotegerin at 3 month at the EOC than the IOC sites might bode well for good osseointegration.
Golomb-rice coding optimized via LPC for frequency domain audio coder

We have devised a method to optimize Golomb-Rice coding of frequency spectra, aiming at its use in frequency domain audio coder, using spectral envelopes extracted by linear predictive coding (LPC) from amplitude spectra instead of conventional power spectra according to theoretical investigations. This optimization improves the efficiency of the Golomb-Rice coding by allocating Rice parameter at each frequency bin based on the value of the envelopes, resulting in the enhancement of the objective and subjective quality of the state-of-the-art wideband coder at 16 kbit/s. Therefore, the method introduced here is expected to be useful for coding audio signals at low-bit-rate and low-delay conditions, required in mobile communications.
Distribution of methane in the Lena Delta and Buor-Khaya Bay, Russia

The Lena River is one of the largest Russian rivers draining into the Laptev Sea. The permafrost areas surrounding the Lena are predicted to thaw at increasing rates due to global temperature increases. With this thawing, large amounts of carbon – either organic or in the gaseous forms carbon dioxide and methane – will reach the waters of the Lena and the adjacent Buor-Khaya Bay (Laptev Sea). Methane concentrations and the isotopic signal of methane in the waters of the Lena Delta and estuary were monitored from 2008 to 2010. Creeks draining from permafrost soils produced hotspots for methane input into the river system (median concentration 1500 nM) compared with concentrations of 30–85 nM observed in the main channels of the Lena. No microbial methane oxidation could be detected; thus diffusion is the main process of methane removal. We estimated that the riverine diffusive methane flux is 3–10 times higher than the flux from surrounding terrestrial environment. To maintain the observed methane concentrations in the river, additional methane sources are necessary. The methane-rich creeks could be responsible for this input. In the estuary of Buor-Khaya Bay, methane concentrations decreased to 26–33 nM. However, within the bay no consistent temporal and spatial pattern could be observed. The methane-rich waters of the river were not diluted with marine water because of a strong stratification of the water column. Thus, methane is released from the estuary and from the river mainly by diffusion into the atmosphere.
Realistic and Efficient Modeling of Radiotracer Heterogeneity in Monte Carlo Simulations of PET Images With Tumors

Monte Carlo simulations are extensively used in PET to evaluate the accuracy with which PET images can yield reliable estimates of parameters of interest. For such applications, the simulated images should be as realistic as possible so that conclusions can be extrapolated to clinical PET images. In this work, we describe a method for introducing realistic modeling of radiotracer heterogeneity into Monte Carlo simulations of patient PET scans. The modeling of the complex physiological activity distribution in healthy regions is directly based on real patient PET/CT images, and realistic tumor shapes can be included into these regions. This method represents a competitive alternative to the use of complex anthropomorphic phantoms such as the XCAT, that require a fixed activity per structure. The method is extended to the simulation of serial PET scans with tumor changes, as acquired in the context of therapy monitoring, and this extension is validated using a patient study. Using the proposed method, very realistic patient PET images can be produced for evaluation purposes.In addition, a strategy to efficiently simulate many sets of pathological cases, based on a unique background physiological activity distribution, is described and carefully assessed using a numerical phantom. The background activity is simulated only once, while tumors are simulated separately. The data are then recombined in a specific way so that the final image has the same properties as images produced by simulating pathological and tumor activities at the same time.
Non-Thermal Irreversible Electroporation (N-TIRE) and Adjuvant Fractionated Radiotherapeutic Multimodal Therapy for Intracranial Malignant Glioma in a Canine Patient

Non-thermal irreversible electroporation (N-TIRE) has shown promise as an ablative therapy for a variety of soft-tissue neoplasms. Here we describe the therapeutic planning aspects and first clinical application of N-TIRE for the treatment of an inoperable, spontaneous malignant intracranial glioma in a canine patient. The N-TIRE ablation was performed safely, effectively reduced the tumor volume and associated intracranial hypertension, and provided sufficient improvement in neurological function of the patient to safely undergo adjunctive fractionated radiotherapy (RT) according to current standards of care. Complete remission was achieved based on serial magnetic resonance imaging examinations of the brain, although progressive radiation encephalopathy resulted in the death of the dog 149 days after N-TIRE therapy. The length of survival of this patient was comparable to dogs with intracranial tumors treated via standard excisional surgery and adjunctive fractionated external beam RT. Our results illustrate the potential benefits of N-TIRE for in vivo ablation of undesirable brain tissue, especially when traditional methods of cytoreductive surgery are not possible or ideal, and highlight the potential radiosensitizing effects of N-TIRE on the brain.
SWITCHED CAPACITOR VOLTAGE CONVERTERS n No Inductors ! n Minimal Radiated EMI n Simple Implementation : Only 2 External Capacitors

The two most common switched capacitor voltage converters are the voltage inverter and the voltage doubler circuit shown in Figure 4.1. In the voltage inverter, the charge pump capacitor, C1, is charged to the input voltage during the first half of the switching cycle. During the second half of the switching cycle, its voltage is inverted and applied to capacitor C2 and the load. The output voltage is the negative of the input voltage, and the average input current is approximately equal to the output current. The switching frequency impacts the size of the external capacitors required, and higher switching frequencies allow the use of smaller capacitors. The duty cycle defined as the ratio of charging time for C1 to the entire switching cycle time is usually 50%, because that generally yields the optimal charge transfer efficiency.
Countrywide Reassessment of Schistosoma mansoni Infection in Burundi Using a Urine-Circulating Cathodic Antigen Rapid Test: Informing the National Control Program

Following implementation of the national control program, a reassessment of Schistosoma mansoni prevalence was conducted in Burundi to determine the feasibility of moving toward elimination. A countrywide cluster-randomized cross-sectional study was performed in May 2014. At least 25 schools were sampled from each of five eco-epidemiological risk zones for schistosomiasis. Fifty randomly selected children 13–14 years of age per school were included for a single urine-circulating cathodic antigen (CCA) rapid test and, in a subset of schools, for duplicate Kato-Katz slide preparation from a single stool sample. A total of 17,331 children from 347 schools were tested using CCA. The overall prevalence of S. mansoni infection, when CCA trace results were considered negative, was 13.5% (zone range [zr] = 4.6–17.8%), and when CCA trace results were considered positive, it was 42.8% (zr = 34.3–49.9%). In 170 schools, prevalence of this infection determined using Kato-Katz method was 1.5% (zr ==0–2.7%). The overall mean intensity of S. mansoni infection determined using Kato-Katz was 0.85 eggs per gram (standard deviation = 10.86). A majority of schools (84%) were classified as non-endemic (prevalence = 0) using Kato-Katz; however, a similar proportion of schools were classified as endemic when CCA trace results were considered negative (85%) and nearly all (98%) were endemic when CCA trace results were considered positive. The findings of this nationwide reassessment using a CCA rapid test indicate that Schistosoma infection is still widespread in Burundi, although its average intensity is probably low. Further evidence is now needed to determine the association between CCA rapid test positivity and low-intensity disease transmission.
A Common Variant in MIR182 Is Associated With Primary Open-Angle Glaucoma in the NEIGHBORHOOD Consortium

Purpose Noncoding microRNAs (miRNAs) have been implicated in the pathogenesis of glaucoma. We aimed to identify common variants in miRNA coding genes (MIR) associated with primary open-angle glaucoma (POAG). Methods Using the NEIGHBORHOOD data set (3853 cases/33,480 controls with European ancestry), we first assessed the relation between 85 variants in 76 MIR genes and overall POAG. Subtype-specific analyses were performed in high-tension glaucoma (HTG) and normal-tension glaucoma subsets. Second, we examined the expression of miR-182, which was associated with POAG, in postmortem human ocular tissues (ciliary body, cornea, retina, and trabecular meshwork [TM]), using miRNA sequencing (miRNA-Seq) and droplet digital PCR (ddPCR). Third, miR-182 expression was also examined in human aqueous humor (AH) by using miRNA-Seq. Fourth, exosomes secreted from primary human TM cells were examined for miR-182 expression by using miRNA-Seq. Fifth, using ddPCR we compared miR-182 expression in AH between five HTG cases and five controls. Results Only rs76481776 in MIR182 gene was associated with POAG after adjustment for multiple comparisons (odds ratio [OR] = 1.23, 95% confidence interval [CI]: 1.11–1.42, P = 0.0002). Subtype analysis indicated that the association was primarily in the HTG subset (OR = 1.26, 95% CI: 1.08–1.47, P = 0.004). The risk allele T has been associated with elevated miR-182 expression in vitro. Data from ddPCR and miRNA-Seq confirmed miR-182 expression in all examined ocular tissues and TM-derived exosomes. Interestingly, miR-182 expression in AH was 2-fold higher in HTG patients than nonglaucoma controls (P = 0.03) without controlling for medication treatment. Conclusions Our integrative study is the first to associate rs76481776 with POAG via elevated miR-182 expression.
Gastric cytoprotection and honey intake in albino rats.

Beneficial effect of honey has been widely reported particularly on wound healings, gastrointestinal disorders and as antibacterial agent. However, there is paucity of report on its cytoprotective effect on the gastric mucosa despite its common usage worldwide including Nigeria. This study was therefore carried out to evaluate the effect of this widely consumed substance on gastric mucosa using animal model and also to explore possible mechanism of its action on the gastric mucosa . Twenty male adult albino rats of Wistar strain, weighing between 210-220g were used in the experiment. They were randomly assigned into two groups, the control group and the honey-fed (test) group, each containing ten rats. The Control group was fed on normal rat feed and water while the test group was fed on normal rat feed with honey added to its drinking water (1ml of honey for every initial 10ml of water for each rat daily) for twenty two weeks. After twenty two weeks the rats were weighed after being starved overnight. They were anaesthetized with urethane (0.6ml/100g body weight). Gastric ulceration was induced using 1.5ml acid-alcohol prepared from equivolume of 0.1NHCl and 70% methanol introduced into the stomach via a portex cannula tied and left in place following an incision made on the antral-pyloric junction of the stomach. The acid-alcohol was allowed to stay for 1hr. After 1hr, laparatomy was performed and the stomach isolated, cut open along the greater curvature, rinsed with normal saline and fastened in place with pins on a dissecting board for ulcer examination and scores. The result obtained showed mean ulcer scores of 14.5+/-0.70 for the control group and 1.6+/-0.11 for the test group. The result showed that honey significantly reduced ulcer scores as well as caused scanty haemorrhage in the test group compared with increased ulcer scores and multiple haemorrhage in the control group. It is therefore concluded that honey intake offered cytoprotection on the gastric mucosa of albino rats.
Physiological Impact of Fenugreek, Guava and Lantana on the Growth and Some Chemical Parameters of Sunflower Plants and Associated Weeds

Allelopathy is considered an effective and environmentally friendly method to control the weeds and consequently enhances crop production. Pot experiments were conducted during two successive summer seasons (2010 and 2011) in the greenhouse of National Research Centre, Egypt to study the effect of incorporating 10% fenugreek seeds or 20% guava leaves or 20% lantana leaves into the soil on sunflower plants and associated weeds. All treatments caused significant decreases in fresh and dry weights of Echinochloa colonum L. and Portulaca oleracea L at 40 and 100 days after sowing. Fenugreek treatment showed more pronounced effect > lantana treatment > guava treatment. On the other hand, all treatments caused significant increases in the photosynthetic pigments of sunflower leaves (chlorophyll a, b and carotenoid) relative to unweeded treatment. The total carbohydrate content in sunflower leaf tissues increased significantly with all treatments accompanied by a significant decrease in the total phenolic content relative to unweeded treatment. The head weight, seeds weight/head and 100 seeds weight were increased in the following order weed free treatment > fenugreek treatment > lantana treatment > guava treatment. It was noted that fenugreek treatment is the most effective treatment in increasing oil% followed by guava treatment, while the lowest increase resulted from lantana treatment relative to unweeded treatment. Fenugreek treatment caused the highest decrease in (C16:0 + C18:0) accompanied by the highest increase in (C18:1 + C18:2). Regarding the total essential amino acids, it was noticed that fenugreek treatment showed a noticeable increase whereas lantana and guava treatments showed a decrease in total essential amino acids relative to unweeded treatment. All applied treatments showed significant increases in N%, and non significant increases in P% and K% relative to unweeded treatment. (Mona G. Dawood, Mohamed E. El-Awadi and Kowthar G. El-Rokiek. Physiological Impact of Fenugreek, Guava and Lantana on the Growth and Some Chemical Parameters of Sunflower Plants and Associated Weeds. J Am Sci 2012;8(6):166-174). (ISSN: 1545-1003). http://www.sciencepub. net/american. 20
Hydrothermal Carbonization (HTC) of Dry Leaves

was achieved, which started to decrease with further increase in temperature. The lowest yield of 57.39 % was analyzed at 250°C, which shows 13.59% of decrease in yield of hydrochar after heating to 250°C. Increase in temperature trend to decrease the yield of hydrochar while it increases the amount of ash content [3]. The pH of feedstock was 4.34, which increased to 5.45 when heated at 250°C. The high pH of hydrochar helps to offset soil acidity [3], which shows greater use of hydrochar in soil. Surface area (BET) of biomass was 1.39 m²/g and after treatment at 250°C, it increased to 2.09 m²/g, with 52% of increase in surface area of hydrochar.
Hybrid Nanoparticle Systems: New Materials for Sensing and Functional Bio-Applications

Volume 3 • Issue 3 • 1000e105 J Nanomedic Nanotechnol ISSN:2157-7439 JNMNT an open access journal The interface between biology and nonmaterial’s is an emerging frontier for research and development in science and technology. Currently significant research activities are focused on using or imitating biological materials, including self-assembly in living and synthetic materials [1], bio-functionalization of nanomaterials [2], control of cell behavior through nano-engineered materials [3], and hybrid systems consisting of biomolecules and inorganic materials, such as Metallic Nanoparticles (MNPs) and semiconductor Quantum Dots (QDs). These systems, which are of interest for various applications (including biosensors [4], responsive nanoparticle systems [5,6], etc;) are mostly based on the intrinsic resonances of QDs (excitons) and MNPs (plasmons), Forster energy transfer, and the impact of environment on biomolecules. Considerable research efforts have already been devoted to studying possible applications of such systems for biosensors that can sensitively monitor binding events in real time and can detect a variety of processes, including self-assembled monolayer formation [7], protein-ligand and antibody-protein interactions [8-9], DNA hybridization [10], and protein conformational changes [11].
The role of localized plastic flow in the impact initiation of explosives

Individual crystals of silver and lead azide have been impacted by spherical particles. Im pact was at normal incidence on flat faces of the explosives. A novel feature of the experiment was that the particles were very small compared with the millimetre dimension crystals. This meant that the impact damage was independent of the shape of the explosive. Initiation took place when critical conditions of particle size and velocity were exceeded. It was possible to examine the deformation produced when the impact conditions were just subcritical and show that it was primarily plastic. If the deformation energy were uniformly distributed around the indentation, only a small temperature rise would be produced. However, it is suggested that, because of thermal softening, the deformation is concentrated in narrow bands of material by adiabatic shear. The temperature rise in these regions could become high enough for initiation. The discussion is extended to compacted explosives and conditions are considered under which local plastic flow can take place. Finally, the advantages of microparticle impact for testing the sensitiveness of explosives, and situations where particle impact has practical interest are described.
Study of Attenuation of Cardiovascular Response during Laryngoscopy and Intubation Using Two Different Doses of Pregabalin as Premedication in Controlled Hypertensive Patients-A RCT

Introduction: laryngoscopy and tracheal intubation are powerful noxious stimuli that should be attenuated.1 effect more severe in hypertensive patients.2 The present study evaluated the safe and clinically effective dose of oral pregabalin as premedication for attenuation of pressor response of airway instrumentation in controlled hypertensive patients. Methods: After ethical committee clearance total of 90 controlled hypertensive adult consented patients aged 30-60 years(M/F),ASA grade II were included,and randomized into three groups of 30 patients each by computer generated random number tables. Group I received oral placebo, Group II oral pregabalin 75 mg HS+150 mg 1 h before surgery and Group III oral pregabalin 75 mg HS+300 mg 1 h prior to induction. Duration of study 2012-2013. Data was analysed using Chi-square, Anova and T test and statistical analysis was performed using SPSS, windows version 19.0. the power of the study from primary object is 80 %. Anaesthetic technique was standardized and all groups were assessed for preâoperative sedation, haemodynamic changes after the premedication, before and after induction, after laryngoscopy and intubation. Results: Preâoperative sedation levels were higher with pregabalin premedication. Significant increase in heart rate and mean arterial pressure was observed in Groups I and II after airway instrumentation, while statistically significant attenuation of mean arterial pressure was seen in Group III. No significant decrease in heart rate was observed in any group. Conclusion: Oral pregabalin as premedication adequately sedated the patients, attenuated haemodynamic pressor response in a doseârelated fashion.
Incidence of common postural abnormalities in the cervical, shoulder, and thoracic regions and their association with pain in two age groups of healthy subjects.

The purposes of this study were to identify the incidence of postural abnormalities of the thoracic, cervical, and shoulder regions in two age groups of healthy subjects and to explore whether these abnormalities were associated with pain. Eighty-eight healthy subjects, aged 20 to 50 years, were asked to answer a pain questionnaire and to stand by a plumb line for postural assessment of forward head, rounded shoulders, and kyphosis. Subjects were divided into two age groups: a 20- to 35-year-old group (mean = 25, SD = 63) and a 36- to 50-year-old group (mean = 47, SD = 2.6). Interrater and intrarater reliability (Cohen's Kappa coefficients) for postural assessment were established at . 611 and . 825, respectively. Frequency counts revealed postural abnormalities were prevalent (forward head = 66%, kyphosis = 38%, right rounded shoulder = 73%, left rounded shoulder = 66%). No relationship was found between the severity of postural abnormality and the severity and frequency of pain. Subjects with more severe postural abnormalities, however, had a significantly increased incidence of pain, as determined by chi-square analysis (critical chi 2 = 6, df = 2, P less than .05). Subjects with kyphosis and rounded shoulders had an increased incidence of interscapular pain, and those with a forward-head posture had an increased incidence of cervical, interscapular, and headache pain.
Magnetocaloric Properties of Perovskite-Type Manganite La0.65Sr0.2Na0.15MnO3

Polycrystalline perovskite-type manganite La0.65Sr0. 2Na0.15MnO3 was prepared by sol-gel method. An X-ray diffraction measurement showed that the sample was a single phase. The Curie temperature of the sample was determined to be 350K. The maximum magnetic entropy change |ΔSM| corresponding to a 1T magnetic field variation was found to be 1.08 J/kg K and about 40.6 J/kg of relative cooling power was obtained near the Curie temperature. The first-order or the second-order on the phase transition of the manganite was distinguished by Banerjee criteria.