Miracle-dz/UniFAR-FTUs huggingface dataset:
ALDH1 and podoplanin expression patterns predict the risk of malignant transformation in oral leukoplakia

Oral leukoplakia (OL) is a clinically diagnosed preneoplastic lesion of the oral cavity with an increased oral cancer risk. However, the risk of malignant transformation is still difficult to assess. The objective of the present study was to examine the expression patterns of aldehyde dehydrogenase 1 (ALDH1) and podoplanin in OL, and to determine their roles in predicting oral cancer development. In the present study, the expression patterns of ALDH1 and podoplanin were determined in samples from 79 patients with OL. The association between protein expression and clinicopathological parameters, including oral cancer-free survival, was analyzed during a mean follow-up period of 3.4 years. Expression of ALDH1 and podoplanin was observed in 61 and 67% patients, respectively. Kaplan-Meier analysis demonstrated that the expression of the proteins was correlated with the risk of progression to oral cancer. Multivariate analysis revealed that expression of ALDH1 and podoplanin was associated with 3.02- and 2.62-fold increased risk of malignant transformation, respectively. The malignant transformation risk of OL was considerably higher in cases with expression of both proteins. Point-prevalence analysis revealed that 66% of patients with co-expression of ALDH1 and podoplanin developed oral cancer. Taken together, our data indicate that ALDH1 and podoplanin expression patterns in OL are associated with oral cancer development, suggesting that ALDH1 and podoplanin may be useful biomarkers to identify OL patients with a substantially high oral cancer risk.
Influence of Full-body Water Immersion on Esophageal Motor Function and Intragastric Pressure

Background/Aims In Japan, it is customary to take a daily bath during which the body is immersed in water to the neck. During full-body immersion, hydrostatic pressure is thought to compress the chest and abdomen, which might influence esophageal motor function and intra-gastric pressure. However, whether water immersion has a significant influence on esophageal motor function or intragastric pressure has not been shown. The aim of this study was to clarify the influence of full-body water immersion on esophageal motor function and intragastric pressure. Methods Nine healthy male volunteers (mean age 40.1 ± 2.8 years) were enrolled in this study. Esophageal motor function and intragastric pressure were investigated using a high-resolution 36-channel manometry device. Results All subjects completed the study protocol. Intragastric pressure increased significantly from 4.2 ± 1.1 to 20.6 ± 1.4 mmHg with full-body water immersion, while the lower esophageal high pressure zone (LEHPZ) value also increased from 20.5 ± 2.2 to 40.4 ± 3.6 mmHg, with the latter being observed regardless of dietary condition. In addition, peak esophageal peristaltic pressure was higher when immersed as compared to standing out of water. Conclusions Esophageal motor function and intragastric pressure were altered by full-body water immersion. Furthermore, the pressure gradient between LEHPZ and intragastric pressures was maintained at a high level, and esophageal peristaltic pressure was elevated with immersion.
HST observations rule out the association between Cir X-1 and SNR G321.9-0.3

Cir X-1 is one of the most intriguing galactic X-ray sources. It is a16.6 days variable X/radio source, a type-I X-ray burster and a QPO emitter. In spite of an uncertain optical counterpart classication, all these properties identify the source as an LMXB. The morphology of the surrounding radio nebula has suggested an association with the nearby (25 arcmin) SNR G321.9-0.3, implying that Cir X-1 is a runaway binary originated from the supernova explosion 10 5 years ago. To investigate this hypothesis, we carried out a proper motion measurement of the Cir X-1 m 19 optical counterpart using a set of HST/WFC and WFPC2 observations taken 8.6 years apart. We obtained a 3 upper limit of 5m as yr 1 on the source proper motion. Since the runaway hypothesis would have implied a proper motion due North ranging between 15 and 75 mas yr 1 , depending on the actual age of the SNR, our result denitively rules out the association between Cir X-1 and SNR G321.9-0.3.
Resolution Enhancement in Multi-Image Stereo

Under stereo settings, the twin problems of image superresolution (SR) and high-resolution (HR) depth estimation are intertwined. The subpixel registration information required for image superresolution is tightly coupled to the 3D structure. The effects of parallax and pixel averaging (inherent in the downsampling process) preclude a priori estimation of pixel motion for superresolution. These factors also compound the correspondence problem at low resolution (LR), which in turn affects the quality of the LR depth estimates. In this paper, we propose an integrated approach to estimate the HR depth and the SR image from multiple LR stereo observations. Our results demonstrate the efficacy of the proposed method in not only being able to bring out image details but also in enhancing the HR depth over its LR counterpart.
Bacterial Antagonists of Fungal Pathogens Also Control Root-Knot Nematodes by Induced Systemic Resistance of Tomato Plants

The potential of bacterial antagonists of fungal pathogens to control the root-knot nematode Meloidogyne incognita was investigated under greenhouse conditions. Treatment of tomato seeds with several strains significantly reduced the numbers of galls and egg masses compared with the untreated control. Best performed Bacillus subtilis isolates Sb4-23, Mc5-Re2, and Mc2-Re2, which were further studied for their mode of action with regard to direct effects by bacterial metabolites or repellents, and plant mediated effects. Drenching of soil with culture supernatants significantly reduced the number of egg masses produced by M. incognita on tomato by up to 62% compared to the control without culture supernatant. Repellence of juveniles by the antagonists was shown in a linked twin-pot set-up, where a majority of juveniles penetrated roots on the side without inoculated antagonists. All tested biocontrol strains induced systemic resistance against M. incognita in tomato, as revealed in a split-root system where the bacteria and the nematodes were inoculated at spatially separated roots of the same plant. This reduced the production of egg masses by up to 51%, while inoculation of bacteria and nematodes in the same pot had only a minor additive effect on suppression of M. incognita compared to induced systemic resistance alone. Therefore, the plant mediated effect was the major reason for antagonism rather than direct mechanisms. In conclusion, the bacteria known for their antagonistic potential against fungal pathogens also suppressed M. incognita. Such “multi-purpose” bacteria might provide new options for control strategies, especially with respect to nematode-fungus disease complexes that cause synergistic yield losses.
Full-wave AC-DC converter in CMOS 0.18 micron for vibration electromagnetic energy harvest

This paper presents the design and implementation of full-wave AC-DC converter in 0.18 micron CMOS technology. Five sample voltages were taken from vibration electromagnetic harvester technology (VEHT) and simulated in three operating temperatures of 0, 25, and 70 degrees Celsius. The simulation results yielded: a maximum average power efficiency of 95.02% at 0°C 95.61% at 25°C, and 91.05% at 70°C; and an average regulation percentage of 10.45% at 0°C, 24.91% at 25°C, and 10.15% at 70°C.
Effect of Visualizing Social Interaction on Bulletin Board Systems to Enhance Social Presence of the User

In this study, a social presence theory was examined to evaluate effectiveness of visualizing social interactions within computer mediated communication (CMC). The following three Bulletin Board Systems (BBS) were compared to investigate the relationship between visualizing interaction and enhancing the social presence of the user: a “time-series BBS” which displays writings in time-series; a “tree BBS” which displays relations between writings as a two dimensional tree structure; and a “special visualization system” in which the relation between writings is displayed as a three dimensional tree structure, and the learner's impression and popularity of a writing and the communication flow are visualized using color variations on a writing display. The results revealed significantly different social presence between the three systems, and suggest that the visualization of interaction might be a non-verbal cue to enhance social presence within the CMC context.
A New Intrusion Detection Method Based on Artificial Immune System

Use the algorithm of generating variable-radius detectors to generate detectors. Analyze different effects on detection results by choosing different radii. Test samples need to compare with all detectors to detect intrusions. When the number of detectors is large, the detection speed is slow. Cluster near detectors into an area. The test samples which fall in this area only compare with the detectors in this area not all detectors, so the times of comparing are reduced and the detection speed is increased. For the test sample falling in some area of non-self space which is not covered by any detector, comparing the minimum distance between this test sample and all self training samples with the minimum distance between this test sample and all detectors can judge whether this test sample is non-self It is proved by experiments that this method can increase the detection speed as well as detection rate.
Beyond Canonical Texts: A Computational Analysis of Fanfiction

While much computational work on ﬁction has focused on works in the literary canon, user-created fanﬁction presents a unique opportunity to study an ecosystem of literary production and consumption, embodying qualities both of large-scale literary data (55 billion tokens) and also a social network (with over 2 million users). We present several empirical analyses of this data in order to illustrate the range of affordances it presents to research in NLP, computational social science and the digital humanities. We ﬁnd that fan-ﬁction deprioritizes main protagonists in comparison to canonical texts, has a statistically signiﬁcant difference in attention allocated to female characters, and offers a framework for developing models of reader reactions to stories.
Do Us Stock Markets Typically Overreact to Corporate News Stories?

It is widely believed that once news is made public the information is fully reflected in prices within at most a day or two (the efficient market hypothesis). We test this idea using the set of 245,429 Wall Street Journal corporate news stories from 1973 to 2001. Using computational linguistics methods we classify the stories according to topic, and for each topic with a sufficient number of identified events, we run an event study. Our results differ from popular impressions in several ways. 1. On average there is a reversal or overreaction, so that pre-event and post-event abnormal returns have the opposite sign. 2. Statistically significant return momentum is observed for many days after publication. 3. As a result, the inference to be drawn from an event study is often very sensitive to the assumed event window. 4. The average news story has a bigger and more prolonged impact during a recession than during an expansion.
Implementation of screened hybrid functionals based on the Yukawa potential within the LAPW basis set

The implementation of screened hybrid functionals into the WIEN2K code, which is based on the linearized augmented plane wave (LAPW) basis set, is reported. The Hartree-Fock exchange energy and potential are screened by means of the Yukawa potential as proposed by Bylander and Kleinman [D. M. Bylander and L. Kleinman, Phys. Rev. B 41, 7868 (1990)] for the calculation of the electronic structure of solids with the screened-exchange local density approximation. Details of the formalism, which is based on the method of Massidda, Posternak, and Baldereschi [S. Massidda, M. Posternak, and A. Baldereschi, Phys. Rev. B 48, 5058 (1993)] for the unscreened Hartree-Fock exchange are given. The results for the transition-energy and structural properties of several test cases are presented. The results of calculations of the Cu electric-field gradient in Cu2O are also presented, and it is shown that the hybrid functionals are much more accurate than the standard local-density or generalized gradient approximations.
LDM

With the explosive growth in data volume, the I/O bottleneck has become an increasingly daunting challenge for big data analytics. Economic forces, driven by the desire to introduce flash-based Solid-State Drives (SSDs) into the high-end storage market, have resulted in hybrid storage systems in the cloud. However, a single flash-based SSD cannot satisfy the performance, reliability, and capacity requirements of enterprise or HPC storage systems in the cloud. While an array of SSDs organized in a RAID structure, such as RAID5, provides the potential for high storage capacity and bandwidth, reliability and performance problems will likely result from the parity update operations. In this article, we propose a Log Disk Mirroring scheme (LDM) to improve the performance and reliability of SSD-based disk arrays. LDM is a hybrid disk array architecture that consists of several SSDs and two hard disk drives (HDDs). In an LDM array, the two HDDs are mirrored as a write buffer that temporally absorbs the small write requests. The small and random write data are written on the mirroring buffer by using the logging technique that sequentially appends new data. The small write data are merged and destaged to the SSD-based disk array during the system idle periods. Our prototype implementation of the LDM array and the performance evaluations show that the LDM array significantly outperforms the pure SSD-based disk arrays by a factor of 20.4 on average, and outperforms HPDA by a factor of 5.0 on average. The reliability analysis shows that the MTTDL of the LDM array is 2.7 times and 1.7 times better than that of pure SSD-based disk arrays and HPDA disk arrays.
IQ-Imbalance Compensation for OFDM in the Presence of IBI and Carrier-Frequency Offset

In this paper, we propose a frequency-domain equalization technique for orthogonal frequency division multiplexing (OFDM) transmission over frequency-selective channels. We consider the case where the receiver analog front-end suffers from IQ-imbalance and the local oscillator suffers from carrier-frequency offset (CFO). While the IQ-imbalance results in a mirroring effect, the CFO induces inter-carrier interference (ICI). In addition to ICI, we consider the channel delay spread is larger than the cyclic prefix (CP). This means that inter-block interference (IBI) is present. The frequency-domain equalizer is obtained by transferring a time-domain equalizer (TEQ) to the frequency-domain resulting in a per-tone equalizer (PTEQ). Due to the presence of IQ-imbalance the conventional TEQ (where only one TEQ is applied to the received sequence) is not sufficient to cope with the mirroring effect. A sufficient TEQ consists of two time-domain filters; one applied to the received sequence and another applied to a conjugated version of the received sequence. For the case of IQ-imbalance and CFO, the TEQs are designed according the basis expansion model (BEM) which showed to be able to cope with the ICI problem. Finally, in addition to the frequency-domain PTEQ design procedure, a training-based RLS type initialization scheme for direct per-tone equalization is also proposed
Improving power reliably in hostile territory through solar energy — A case study of Gaza strip

In hostile circumstances the most vulnerable target to subvert the power of enemy is to destroy literally the power house of all activities i.e. Electrical Power Plants. In the conventional method of bulk power generation through thermal, hydro or nuclear power plant; any military attacks not only affects the power supply of the area but comes with high collateral damage due to blast of power system itself or a flood due to attack on dam. Therefore this paper proposes to invest for distributed power generation, more so because it has to be consumed in distributed fashion ultimately by user and it also saves heavily on GTD infrastructure as well as fuel. We propose a denomination of distributed solar systems in capacities of 1kW, 500W and 300W with investment cost $4000, $2000 and $1000. We conclude that not only this method pass the breakeven point of grid parity in 7.61 years, it also proved quite impregnable in case of enemy's air attack in hostile territories.
Tie-breaking for EDF on multiprocessor platforms

Scheduling real-time systems on multiprocessors introduces complexities that do not arise when using uniprocessors. When scheduling using EDF on multiprocessor platforms, breaking deadline ties in different ways can change the resulting schedule dramatically. We consider methods to resolve the ambiguities in EDF priorities due to coincident deadlines. We show that no optimal ambiguity solver can be online. We also show that no optimal static tiebreaker exists even if we relax the on-line property.
Identification and importance of brown adipose tissue in adult humans.

BACKGROUND Obesity results from an imbalance between energy intake and expenditure. In rodents and newborn humans, brown adipose tissue helps regulate energy expenditure by thermogenesis mediated by the expression of uncoupling protein 1 (UCP1), but brown adipose tissue has been considered to have no physiologic relevance in adult humans. METHODS We analyzed 3640 consecutive (18)F-fluorodeoxyglucose ((18)F-FDG) positron-emission tomographic and computed tomographic (PET-CT) scans performed for various diagnostic reasons in 1972 patients for the presence of substantial depots of putative brown adipose tissue. Such depots were defined as collections of tissue that were more than 4 mm in diameter, had the density of adipose tissue according to CT, and had maximal standardized uptake values of (18)F-FDG of at least 2.0 g per milliliter, indicating high metabolic activity. Clinical indexes were recorded and compared with those of date-matched controls. Immunostaining for UCP1 was performed on biopsy specimens from the neck and supraclavicular regions in patients undergoing surgery. RESULTS Substantial depots of brown adipose tissue were identified by PET-CT in a region extending from the anterior neck to the thorax. Tissue from this region had UCP1-immunopositive, multilocular adipocytes indicating brown adipose tissue. Positive scans were seen in 76 of 1013 women (7.5%) and 30 of 959 men (3.1%), corresponding to a female:male ratio greater than 2:1 (P<0.001). Women also had a greater mass of brown adipose tissue and higher (18)F-FDG uptake activity. The probability of the detection of brown adipose tissue was inversely correlated with years of age (P<0.001), outdoor temperature at the time of the scan (P=0.02), beta-blocker use (P<0.001), and among older patients, body-mass index (P=0.007). CONCLUSIONS Defined regions of functionally active brown adipose tissue are present in adult humans, are more frequent in women than in men, and may be quantified noninvasively with the use of (18)F-FDG PET-CT. Most important, the amount of brown adipose tissue is inversely correlated with body-mass index, especially in older people, suggesting a potential role of brown adipose tissue in adult human metabolism.
Assembly independent functional annotation of short-read data using SOFA: Short-ORF functional annotation

Accurate description of the microbial communities driving matter and energy transformations in complex ecosystems such as soils cannot yet be effectively accomplished using assembly-based approaches despite the rise of next generation sequencing technologies. Here we present SOFA, an open source pipeline enabling comparative functional annotation of unassembled short-read data. The pipeline attempts to merge mate pairs in fastq files, predicts open reading frames (ORFs) on merged and unmerged reads as small as 70 bps, and completes an additional step, we term `deduplication'. Deduplication prevents the double counting of ORFs predicted from unmerged paired-end reads by checking for homologous annotations that span the same ORF, allowing for quantitatively accurate predictions. The effectiveness of SOFA is validated with both simulated and bone fide soil metagenomes, and empirical results are compared to existing strategies for obtaining accurate ORF counts, and an analytical model of read duplication. SOFA enables downstream processing stages within the existing MetaPathways pipeline, and is available for download as a stand alone application at https://github.com under the MIT license.
High‐power RF photodiodes and their applications

There has been an increasing interest in photonic generation of RF signals in the millimeter‐wave (30 GHz∼300 GHz) and/or terahertz‐wave (0.1 THz∼10 THz) regions, and photodiodes play a key role in it. This paper reviews recent progress in the high‐power RF photodiodes such as Uni‐Traveling‐Carrier‐Photodiodes (UTC‐PDs), which operate at these frequencies. Several approaches to increasing both the bandwidth and output power of photodiodes are discussed, and promising applications to broadband wireless communications and spectroscopic sensing are described.
Modified ElGamal over RSA Digital Signature Algorithm (MERDSA)

Generally digital signature algorithms are based on a single hard problem like prime factorization problem, discrete logarithm problem, elliptic curve problem. If one finds solution of this single hard problem then these digital signature algorithms will no longer be secured and due to large computational power, this may be possible in future. There are many other algorithms which are based on the hybrid combination of prime factorization and discrete logarithms problem but different weaknesses and attacks have been developed against those algorithms. This paper also presents a new variant of digital signature algorithm which is based on two hard problems, prime factorization and discrete logarithm. KEYWORD-Digital Signature; Discrete logarithm; Factorization; Cryptanalysis
ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75NTR and Sortilin

Brain-derived neurotrophic factor (BDNF) is best characterized for critical roles in neuronal survival, differentiation, and synaptic modulation mediated by the TrkB receptor tyrosine kinase. Developmentally regulated death signaling by BDNF has also been demonstrated via activation of p75NTR. Because recent studies suggest that proNGF, the precursor form of NGF, is more active than mature NGF in inducing apoptosis after binding to p75NTR and a coreceptor, sortilin, we asked whether the precursor of BDNF (proBDNF) is also a proapoptotic ligand in the nervous system. proBDNF is secreted by cultured neurons, and recombinant proBDNF binds to sortilin. In sympathetic neurons coexpressing sortilin and p75NTR, we found that proBDNF is an apoptotic ligand that induces death at subnanomolar concentrations. In contrast, mature BDNF, but not proBDNF, is effective in inducing TrkB phosphorylation. proBDNF effects are dependent on cellular coexpression of both p75NTR and sortilin, because neurons deficient in p75NTR are resistant to proBDNF-induced apoptosis, and competitive antagonists of sortilin block sympathetic neuron death. Moreover, addition of preformed complexes of soluble sortilin and proBDNF failed to induce apoptosis of cells coexpressing both sortilin and p75NTR, suggesting that interaction of proBDNF with both receptors on the cell surface is required to initiate cell death. Together with our past findings, these data suggest that the neurotrophin family is capable of modulating diverse biological processes via differential processing of the proneurotrophins.