Miracle-dz/UniFAR-FTUs huggingface dataset:
Targeting the insulin-like growth factor-1 receptor in human cancer

The insulin-like growth factor (IGF) signaling system plays a crucial role in human cancer and the IGF-1 receptor (IGF-1R) is an attractive drug target against which a variety of novel anti-tumor agents are being developed. Deregulation of the IGF signaling pathway frequently occurs in human cancer and involves the establishment of autocrine loops comprising IGF-1 or IGF-2 and/or IGF-1R over-expression. Epidemiologic studies have documented a link between elevated IGF levels and the development of solid tumors, such as breast, colon, and prostate cancer. Anti-cancer strategies targeting the IGF signaling system involve two main approaches, namely neutralizing antibodies and small molecule inhibitors of the IGF-1R kinase activity. There are numerous reports describing anti-tumor activity of these agents in pre-clinical models of major human cancers. In addition, multiple clinical trials have started to evaluate the safety and efficacy of selected IGF-1R inhibitors, in combination with standard chemotherapeutic regimens or other targeted agents in cancer patients. In this mini review, I will discuss the role of the IGF signaling system in human cancer and the main strategies which have been so far evaluated to target the IGF-1R.
Polynomials that Vanish on Distinct $n$th Roots of Unity

Let ${\bf C}$ denote the field of complex numbers and $\Omega_n$ the set of $n$th roots of unity. For $t = 0,\ldots,n-1$, define the ideal $\Im(n,t+1) \subset {\bf C}[x_0,\ldots,x_{t}]$ consisting of those polynomials in $t+1$ variables that vanish on distinct $n$th roots of unity; that is, $f \in \Im(n,t+1)$ if and only if $f(\omega_0,\ldots,\omega_{t}) = 0$ for all $(\omega_0,\ldots,\omega_{t}) \in \Omega_n^{t+1}$ satisfying $\omega_i \neq \omega_j$, for $0 \le i < j \le t$. In this paper we apply Gröbner basis methods to give a Combinatorial Nullstellensatz characterization of the ideal $\Im(n,t+1)$. In particular, if $f \in {\bf C}[x_0,\ldots,x_{t}]$, then we give a necessary and sufficient condition on the coefficients of $f$ for membership in $\Im(n,t+1)$.
Low cost high throughput affine transformation engine using FPGA

Geometric transformation is widely used in image processing applications especially in the ones in which image registration is required. Electronic image stabilization, super-resolution, sensor fusion can be given as featured example applications requiring a qualitative registration. Affine transformation is a kind of geometric transformation providing sufficient solution for video streams since it covers necessary transformations such as rotation, scaling, shearing, and translation. However this transformation requires enormous matrix operations like matrix multiplications and additions which makes real time hardware implementation a challenging task. In this paper, the methodology of a fully pipelined architecture design by using FPGA is explained to meet the real time requirements of affine transformation for high resolution video streams. A fully pipelined tile based engine was created in order to perform transformation by aiming maximizing throughput. The design was implemented on Altera's Stratix VFPGA as a real-time system that has the capability of processing full HD video streams.
Consensus Network Decoding for Statistical Machine Translation System Combination

This paper presents a simple and robust consensus decoding approach for combining multiple machine translation (MT) system outputs. A consensus network is constructed from an N-best list by aligning the hypotheses against an alignment reference, where the alignment is based on minimising the translation edit rate (TER). The minimum Bayes risk (MBR) decoding technique is investigated for the selection of an appropriate alignment reference. Several alternative decoding strategies proposed to retain coherent phrases in the original translations. Experimental results are presented primarily based on three-way combination of Chinese-English translation outputs, and also presents results for six-way system combination. It is shown that worthwhile improvements in translation performance can be obtained using the methods discussed.
Educating Capitalists: A Rejoinder to Wright and Tsakalotos

The paper takes up the basic issue, addressed by both commentators, of whether one can speak of economic performance as a general interest superseding the special interests of groups or classes. It suggests a dynamic concept of capitalist class interests that allows for a contingent, precarious, and perhaps increasingly less feasible reconciliation between general and special interests in economic performance.
A mobile peer-to-peer system for opportunistic content-centric networking

In this work we present a middleware architecture for a mobile peer-to-peer content distribution system. Our architecture allows wireless content dissemination between mobile nodes without relying on infrastructure support. Contents are exchanged opportunistically when nodes are within communication range. Applications access the service of our platform through a publish/subscribe interface and therefore do not have to deal with low-level opportunistic networking issues or matching and soliciting of contents. Our architecture consists of three key components. A content structure that facilitates dividing contents into logical topics and allows for efficient matching of content lookups and downloading under sporadic node connectivity. A solicitation protocol that allows nodes to solicit content meta-information in order to discover contents available at a neighboring node and to download content entries disjointedly from different nodes. An API that allows applications to access the system services through a publish/subscribe interface. In this work we describe the design and implementation of our architecture. We also discuss potential applications and present evaluation results from profiling of our system.
A KINETIC ANALYSIS OF MYOGENESIS IN VITRO

Conditions which yielded reproducible growth kinetics with extensive, relatively synchronous differentiation are described for chick muscle cultures. The effects of cell density and medium changes on the timing of cell fusion were examined. Low-density cultures which received a change of medium at 24 hr after plating show the highest rate of cell fusion, increasing from 15 to 80% fused cells in a 10 hr period. These optimal culture conditions were employed to reexamine two questions from the earlier literature on muscle culture: (a) can cells which normally would fuse at the end of one cell cycle be forced to go through another cell cycle before fusion; and (b) how soon after its final S period can a cell complete fusion? In answer to the first question, it was found that if the medium is changed, many cells which would otherwise fuse can be made to undergo another cell cycle before fusion. In the second case, radioautographs were made from cultures incubated with tritiated thymidine for various times at the beginning of the fusion period. These show labeled nuclei in myotubes as early as 3 hr after the beginning of the incubation period. This indicates that cells can fuse as early as the beginning of the G1 period, and suggests that there is not an obligatory exit from the cell cycle or a prolonged G1 period before cell fusion and differentiation during myogenesis.
What Smart Grid means to an ISO/RTO?

The seven Independent System Operators and Regional Transmission Organizations (ISO/RTOs) in the United States coordinate reliable power grid operations for two-thirds of its population and its electric generation. Each ISO/RTO provides regional planning and operation, energy market operation, outage coordination, transactions settlement, billing and collections, risk management, ancillary services, credit risk management, and more services. This paper shows how Smart Grid affects the essential roles in operation, market and planning in ISO/RTO. This paper also discusses current Smart Grid projects in PJM which covers 13 states and DC area in Northeast US. Some of the future smart grid trend and challenges in PJM and industry are discussed too.
Statistical analysis of the LMS algorithm with a zero-memory nonlinearity after the adaptive filter

This paper presents a statistical analysis of the least mean square (LMS) algorithm when a zero-memory nonlinearity appears at the adaptive filter output. The nonlinearity is modelled by a scaled error function. Deterministic nonlinear recursions are derived for the mean weight and mean square error (MSE) behavior for white Gaussian inputs and slow adaptation. Monte Carlo simulations show excellent agreement with the behavior predicted by the theoretical models. The analytical results show that a small nonlinear effect has a significant impact on the converged MSE.
SYNAPTIC PLASTICITY: UNDERSTANDING THE NEUROBIOLOGICAL MECHANISMS OF LEARNING AND MEMORY. PART I

Uno de los fenomenos mas interesantes dentro del campo de la neurobiologia, es el fenomeno de la plasticidad cerebral relacionada con los eventos de aprendizaje y el procesamiento del fenomeno de memoria. De hecho, estos fenomenos neurobiologicos empezaron a ser estudiados desde principios de siglo. Remotamente, el fenomeno de plsticidad cerebral en relacion con el desarrollo y aprendizaje de las conductas fue ya concebido y cuestionado desde hace mas de dos centurias. Sin embargo, desde hace cuatro decadas, multiples evidencias experimentales han demostrado que tanto la experiencia o el entrenameinto en la ejecucion de tareas operantes aprendidas, inducen cambios plasticos en la fisiologia neuronal, incluyendo los cambios neuroquimicos y moleculares que se requieren para consolidar una memoria a largo plazo. Asimismo, diversos procedimientos experimentales han demostrado que la experiencia diferencial, el entrenamiento y el aprendizaje de conductas o la experiencia informal, producen cambios mensurables en el cerebro de los mamiferos. Mas aun, la neuropsicologia ha considerado desde hace varias decadas que diferentes tipos de memoria pueden ser localizados en diferentes circuitos neuronales en distintas areas de la corteza cerebral. Sin embargo, los estudios recientes han demostrado que los sistemas de memoria estan distribuidos en circuitos neuronales corticales especificos. Por ejemplo, los mismos sistemas corticales que procesan la percepcion sensorial y la funcion motora, son los mismos sustratos neurales que se emplean para procesar los fenomenos de memorizacion. El fenomeno de la memoria y el aprendizaje es resultado de la actividad fisiologica receptitiva de millones de neuronas que, ensambladas en circuitos neuronales especificos, conllevan al reforzamiento de las conexiones sinapticas involucradas y a los cambios de platicidad sinaptica que se requieren para establecer estos fenomenos neurobiologicos. El fenomeno de potenciacion a largo plazo, o LTP, es un evento neurofisiologico que resulta del incremento en el reforzamiento de la transmision sinaptica, que puede perdurar en las regiones cerebrales estudiadas desde horas a dias. El modelo de LTP quiza represnta el modelo funcional experimental mas viable para entender las bases celulares del aprendizaje y la memoria en el SNC de los mamiferos, incluyendo el cerebro de los humanos.
Neurological Manifestations of Celiac Disease in Children and Adults

Celiac disease (CD) is a common, life-long, autoimmune condition, affecting the small intestine of genetically susceptible individuals. The classical clinical picture is disappearing as awareness progresses and the extra-intestinal presentation is emerging. Skin, endocrine, hepatic, skeletal, hematological, gynecological, infertility, dental, and behavioral abnormalities are emerging. Among the new growing domains is the extra-intestinal presentation of CD affecting the peripheral and central neurological systems. This review highlights neurological presentations in these patients, focusing on the clinical signs/symptoms in the pediatric and the adult age group, separately.
Isolated total ruptures of the anterior cruciate ligament – a clinical study with long‐term follow‐up of 7 years

Seventy patients met our inclusion criteria in this retrospective study, all with an arthroscopic/arthrotomic‐verified isolated total anterior cruciate ligament (ACL)‐rupture and a minimum follow‐up period of 3 years and no associated lesions. Due to emigration/death, 3 patients were not available for follow‐up. Of the remaining 67, 25 patients underwent secondary ACL‐reconstruction, equivalent to a failure rate of the initial non‐operative treatment of 37%. All patients were initially treated conservatively. This left 42 patients for follow‐up – 9 answered a questionnare and 33 went through follow‐up examination after a median of 7.1 years (range 3.3–14.6) including IKDC‐evaluation form. Lysholm & Tegner score, ES‐SKA‐score, clinical examination and Stryker Laxity test. In the present study all values represent the 33 patients available for follow‐up. Soccer, handball and alpine skiing were most frequently responsible for the injury. We observed in the 33 patients a decline in median Lysholm score from 100 (90–100) pretraumatic to 86 (42–100) at follow‐up, and a decrease in median Tegner values from 7 (3–9) pretraumatic to 5 (2–7) at follow‐up. All but 2 patients demonstrated a decline in Lysholm score, and only 3 patients returned to their preinjury level. According to the ESSKA‐classification, the number of “cutting‐sports performers” declined dramatically from 24 to 2. All but one patient ascribed their decline in activity to their knee status. The Stryker‐measured AP‐translocations were significantly higher on the injured knee (7.27) compared to the healthy knee (4.80) (P<0.05). Intermittant rest pain was suffered by 63% of the patients. During the time from inclusion until follow‐up, 13 (39%) patients sustained an additional ipsilateral knee lesion, most commonly a tear of the medial meniscus. The overall outcome was expressed in a low frequency of return to unrestricted preinjury level of function, and a high level of instability complaints resulting in many secondary ACL‐reconstructions. Naturally some have adapted to their ultimate functional disability, but only through modification of activities, and the overall outcome after conservative therapy of these ACL‐ruptures was not satisfactory.
Economía de la información

Administración y Dirección de Empresas Aplicar los instrumentos matemáticos para sintetizar situaciones económico -empresariales complejas. Capacidad de adaptación a entornos cambiantes. Capacidad de comunicación oral y escrita en catalán, castellano e inglés, que permita sintetizar y presentar oralmente y por escrito el trabajo realizado. Capacidad se seguir aprendiendo en el futuro de forma autónoma, profundizando los conocimientos adquiridos o iniciándose en nuevas áreas de conocimiento Demostrar iniciativa y trabajar autónomamente cuando la situación lo requiera. Identificar las fuerzas que gobiernan la demanda y la oferta. Mostrar una motivación por la calidad del trabajo realizado y una sensibilidad por sus consecuencias en el medioambiente y en la sociedad. Organizar el trabajo, en cuanto a una buena gestión del tiempo, ordenación y planificación del mismo. Seleccionar y generar la información necesaria para cada problema, analizarla, y tomar decisiones en base a la misma. Trabajar en equipo, siendo capaz de argumentar sus propuestas y validar o rehusar razonadamente los argumentos de otras personas.
Beneficial Effects of Proanthocyanidins in the Cardiac Alterations Induced by Aldosterone in Rat Heart through Mineralocorticoid Receptor Blockade

Aldosterone administration in rats results in several cardiac alterations. Previous studies have demonstrated that proanthocyanidins, phenolic bioactive compounds, have cardioprotective effects. We studied the potential beneficial effects of the proanthocyanidin-rich almond skin extract (PASE) on the cardiac alterations induced by aldosterone-salt treatment, their effects in mineralocorticoid receptor activity and we sought to confirm proanthocyanidins as the specific component of the extract involved in the beneficial cardiac effects. Male Wistar rats received aldosterone (1 mg/Kg/day) +1% NaCl for 3 weeks. Half of the animals in each group were simultaneously treated with either PASE (100 mg/Kg/day) or spironolactone (200 mg/Kg/day). The ability of PASE to act as an antagonist of the mineralocorticoid receptor was examined using a transactivation assay. High performance liquid chromatography was used to identify and to isolate proanthocyanidins. Hypertension and diastolic dysfunction induced by aldosterone were abolished by treatment with PASE. Expression of the aldosterone mediator SGK-1, together with fibrotic, inflammatory and oxidative mediators were increased by aldosterone-salt treatment; these were reduced by PASE. Aldosterone-salt induced transcriptional activity of the mineralocorticoid receptor was reduced by PASE. HPLC confirmed proanthocyanidins as the compound responsible for the beneficial effects of PASE. The effects of PASE were comparable to those seen with the mineralocorticoid antagonist, spironolactone. The observed responses in the aldosterone-salt treated rats together with the antagonism of transactivation at the mineralocorticoid receptor by PASE provides evidence that the beneficial effect of this proanthocyanidin-rich almond skin extract is via as a mineralocorticoid receptor antagonist with proanthocyanidins identified as the compounds responsible for the beneficial effects of PASE.
Influence of level of deoxynivalenol in the diet of dairy cows on feed intake, milk production, and its composition.

Eighteen primiparous Holstein cows were used in a 10-wk lactation study, preceded by a 2-wk covariate period, to determine the effect of concentration of deoxynivalenol in the diet on cow performance and transfer of deoxynivalenol and its metabolite, deepoxydeoxynivalenol, to milk. Diets were formulated to contain deoxynivalenol at 0, 6, and 12 mg/kg of concentrate DM, and daily intake of deoxynivalenol was . 59, 42, and 104 mg, respectively. Increasing deoxynivalenol in the diet did not affect intake of concentrate or forage. Total milk output was not affected; however, milk fat responded quadratically; cows given deoxynivalenol at 6 mg/kg of concentrate DM had the lowest milk fat content and fat output. Overall energetic efficiency was not influenced because reduced energy output in milk was compensated by increased BW gains. No transfer of deoxynivalenol or deepoxydeoxynivalenol to milk was observed; concentrations were below detectable limits (1 microgram/ml) using HPLC-mass spectroscopy. We concluded that diets containing deoxynivalenol up to 6 mg/kg of dietary DM did not reduce feed intake of cows in this study and that deoxynivalenol or deepoxydeoxynivalenol was not transferred to milk. Further studies are required to confirm the apparent lack of effect of deoxynivalenol on milk production.
Convergence Speed of Unsteady Distributed Consensus: Decay Estimate Along the Settling Spanning-Trees

Results for estimating the convergence rate of nonstationary distributed consensus algorithms are provided, on the basis of qualitative (mainly topological) as well as basic quantitative information (lower-bounds on the matrix entries). The results appear to be tight in a number of instances and are illustrated through simple as well as more sophisticated examples. The main idea is to follow propagation of information along certain spanning-trees which arise in the communication graph.
Impact of Tissue Harvesting Sites on the Cellular Behaviors of Adipose-Derived Stem Cells: Implication for Bone Tissue Engineering

The advantages of adipose-derived stem cells (AdSCs) over bone marrow stem cells (BMSCs), such as being available as a medical waste and less discomfort during harvest, have made them a good alternative instead of BMSCs in tissue engineering. AdSCs from buccal fat pad (BFP), as an easily harvestable and accessible source, have gained interest to be used for bone regeneration in the maxillofacial region. Due to scarcity of data regarding comparative analysis of isolated AdSCs from different parts of the body, we aimed to quantitatively compare the proliferation and osteogenic capabilities of AdSCs from different harvesting sites. In this study, AdSCs were isolated from BFP (BFPdSCs), abdomen (abdomen-derived mesenchymal stem cells (AbdSCs)), and hip (hip-derived mesenchymal stem cells (HdSCs)) from one individual and were compared for surface marker expression, morphology, growth rate, and osteogenic differentiation capability. Among them, BFPdSCs demonstrated the highest proliferation rate with the shortest doubling time and also expressed vascular endothelial markers including CD34 and CD146. Moreover, the expression of osteogenic markers were significantly higher in BFPdSCs. The results of this study suggested that BFPdSCs as an encouraging source of mesenchymal stem cells are to be used for bone tissue engineering.
The Double Star magnetic field investigation: instrument design, performance and highlights of the first year's observations

One of the primary objectives of the Double Star mission is the accurate measurement of the magnetic field vector along the orbits of the two spacecraft. The magnetic field is an essential parameter for the understanding of space plasma processes and is also required for the effective interpretation of data from the other instruments on the spacecraft. We present the design of the magnetic field instrument onboard both of the Double Star spacecraft and an overview of the performance as measured first on-ground and then in-orbit. We also report the results of in-flight calibration of the magnetometers, and the processing methods employed to produce the final data products which are provided to Double Star investigators, and the wider community in general. Particular attention is paid to the techniques developed for removing magnetic interference generated by the solar arrays on the first (equatorial orbiting) spacecraft. Results from the first year of operations are reviewed in the context of combined observations by Double Star and Cluster, and examples given from the different regions visited by the spacecraft to date.
Somatotypes of Bekasi Children and Adolescent Aged 3-20 Years

SITI NUR FAUZIAH. Somatotypes of Bekasi Children and Adolescent Aged 320 Years. Supervised by BAMBANG SURYOBROTO and PUJI RIANTI. One of quantitative method to describe body shape and composition is somatotype. It is represented by three-score rating that represents endomorphy, mesomorphy, and ectomorphy. Indonesia has diverse ethnic, socioculture, and socio-economic background therefore it is important to study variation of body shape and composition using quantitative method in each city. The aim of this study is to evaluate somatotype of children and adolescent aged 3-20 years in Bekasi. Measurement used technique of somatotype introduced by Heath and Carter. Components of somatotypes changed with ages. At age 3 years girls had somatotype of mesomorph-endomorph. Somatoype changed to endomorph with balanced mesomorph and ectomorph after 12 years. Somatotype of boys at age 3 years is endomorph-mesomorph. Then somatotype changed to balanced endomorph at age 13 years. At age 20 years, somatotype of boys persisted as balanced endomorph. In general, girl had increased endomorphy but boy decreased. Mesomorphy and ectomorphy components of boy were higher than girl at each age group.