Miracle-dz/UniFAR-FTUs huggingface dataset:
Towards an integrated treatment approach for manic depression

Manic Depressive (MD) illness is a severe, chronic and disabling illness; the psychological consequences of which often results in profound distress. For the individual the treatment offered has typically involved pharmacotherapy only, with little or no attention to the cognitive aspects of MD, or the psychological needs of the individual. This paper describes how a similar picture existed in the area of schizophrenia some years ago. It traces the concepts, ideas and model that directed the multimodal approach to the treatment of schizophrenia, and the now widely accepted use of psychosocial interventions. The paper then looks at the problems found in manic depression, the similarities and differences between the two serious mental illnesses, and considers how the adoption of a stress-vulnerability and cognitive model informed the developments in schizophrenia. Consideration is then given to how the application of these models can inform the development of psychosocial interventions for manic depression.
Introduction to Special Issue. Counselors Be Aware: Clients Come in Every Size, Shape, Color, and Sexual Orientation

In order to guarantee that each individual is free to pursue his/her potential, each member of AACD is charged to (a) engage in ongoing examination of his/her own attitudes, feelings, stereotypic views, perceptions and behaviors that might have prejudicial or limiting impact on women, ethnic, minorities, elderly persons, gay/lesbian persons and persons with handicapping conditions; (b) contribute to an increased sensitivity on the part of other individuals, groups or institutions to the barriers to opportunity imposed by discrimination; (c) advocate equal rights for all individuals through concerted personal, professional and political activity. (Position paper of the Human Rights Committee of the American Association for Counseling and Development, 1987, p.1)
Production of poly(3-hydroxybutyrate) by fed-batch culture of filamentation-suppressed recombinant Escherichia coli

Recombinant Escherichia coli XL1-Blue harboring a high-copy-number plasmid containing the Alcaligenes eutrophus polyhydroxyalkanoate synthesis genes could efficiently synthesize poly(3-hydroxybutyrate) (PHB) in a complex medium containing yeast extract and tryptone but not in a defined medium. One of the reasons for the reduced PHB production in a defined medium was thought to be severe filamentation of cells in this medium. By overexpressing an essential cell division protein, FtsZ, in recombinant E. coli producing PHB, filamentation could be suppressed and PHB could be efficiently produced in a defined medium. A high PHB concentration of 149 g/liter, with high productivity of 3.4 g of PHB/liter/h, could be obtained by the pH-stat fed-batch culture of the filamentation-suppressed recombinant E. coli in a defined medium. It was also found that insufficient oxygen supply at a dissolved oxygen concentration (DOC) of 1 to 3% of air saturation during active PHB synthesis phase did not negatively affect PHB production. By growing cells to the concentration of 110 g/liter and then controlling the DOC in the range of 1 to 3% of air saturation, a PHB concentration of 157 g/liter and PHB productivity of 3.2 g of PHB/liter/h were obtained. For the scale-up studies, fed-batch culture was carried out in a 50-liter stirred tank fermentor, in which the DOC decreased to zero when cell concentration reached 50 g/liter. However, a relatively high PHB concentration of 101 g/liter and PHB productivity of 2.8 g of PHB/liter/h could still be obtained, which demonstrated the possibility of industrial production of PHB in a defined medium by employing the filamentation-suppressed recombinant E. coli.
Urologic Approaches to Metastatic Renal Cell Carcinoma

The treatment of choice for nondisseminated disease is surgery. However, the 5-year survival rates for all stages do not exceed 60%, even in contemporary series. Further improvement will most likely have to await the development of a more effective systemic therapy and the application of combined treatment modalities to counter the relatively high number of patients presenting with advanced stages. Treatment options in metastatic disease include nephrectomy alone, sometimes in combination with metastasectomy in selected cases, or cytoreductive surgery followed by immunotherapy. Alternatively, one may apply immunotherapy initially and perform adjuvant nephrectomy in the case of a response, or proceed with immunotherapy as a monotherapy. Nevertheless, long-term survival rates range merely from 5 to 10%, depending strongly on patient selection criteria. Concepts and progress in this field appear to be of major interest for modern urooncologists following the advent of immunotherapeutic strategies that require a surgical intervention at some stage of the treatment cascade.
Empirical Studies in Discourse - Introduction

General rights Copyright for the publications made accessible via the Edinburgh Research Explorer is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights. Take down policy The University of Edinburgh has made every reasonable effort to ensure that Edinburgh Research Explorer content complies with UK legislation. If you believe that the public display of this file breaches copyright please contact openaccess@ed.ac. uk providing details, and we will remove access to the work immediately and investigate your claim.
Web 2.0 in education and potential factors of Web 2.0 use by students of information systems

This paper analyzes potential uses of Web 2.0 tools in e-learning. Some of the more popular Web 2.0 tools are briefly explained. Self-assessment scales were developed intended to measure various constructs that could be associated with the use of Web 2.0 tools. These constructs were related to higher levels of information literacy, innovativeness, technological curiosity, internet access, stimulating environment, use of the Internet/web for information exchange, etc. The subjects in our study were informatics students, who were highly information literate. The results of our study indicate that all of the investigated constructs are associated with the use of Web 2.0 tools. Conclusions are drawn regarding the use of the results of our research to facilitate the adoption of Web 2.0 tools by students in more advanced e-learning environments.
Childhood Traumas: An Outline and Overview

Childhood psychic trauma appears to be a crucial etiological factor in the development of a number of serious disorders both in childhood and in adulthood. Like childhood rheumatic fever, psychic trauma sets a number of different problems into motion, any of which may lead to a definable mental condition. The author suggests four characteristics related to childhood trauma that appear to last for long periods of life, no matter what diagnosis the patient eventually receives. These are visualized or otherwise repeatedly perceived memories of the traumatic event, repetitive behaviors, trauma-specific fears, and changed attitudes about people, life, and the future. She divides childhood trauma into two basic types and defines the findings that can be used to characterize each of these types. Type I trauma includes full, detailed memories, “omens,” and misperceptions. Type H trauma includes denial and numbing, self-hypnosis and dissociation, and rage. Crossover conditions often occur after sudden, shocking de.
Simian Virus 40 Infection Down-Regulates the Expression of Nitric Oxide Synthase in Human Mesothelial Cells

The cytotoxic effects of asbestos are partly mediated by the production of free radicals, including nitric oxide (NO). SV40 has been suggested to synergize with asbestos in the pathogenesis of malignant mesothelioma. Crocidolite asbestos fibers induced in human mesothelial and malignant mesothelioma cells a significant increase of NO synthase activity and expression, which was absent in SV40-infected cells. Furthermore, SV40 infection prevented the NFκB activation elicited by crocidolite in both mesothelial and mesothelioma cells. These data suggest that SV40, by inhibiting the synthesis of NO, could favor the survival of transformed, potentially neoplastic cells.
Complex effects of dyslexia risk factors account for ADHD traits: evidence from two independent samples

BACKGROUND Developmental dyslexia (DD) and attention deficit/hyperactivity disorder (ADHD) are among the most common neurodevelopmental disorders, whose etiology involves multiple risk factors. DD and ADHD co-occur in the same individuals much more often than would be expected by chance. Several studies have found significant bivariate heritability, and specific genes associated with either DD or ADHD have been investigated for association in the other disorder. Moreover, there are likely to be gene-by-gene and gene-by-environment interaction effects (G × G and G × E, respectively) underlying the comorbidity between DD and ADHD. We investigated the pleiotropic effects of 19 SNPs spanning five DD genes (DYX1C1, DCDC2, KIAA0319, ROBO1, and GRIN2B) and seven DD environmental factors (smoke, miscarriage, birth weight, breastfeeding, parental age, socioeconomic status, and parental education) for main, either (a) genetic or (b) environmental, (c) G × G, and (d) G × E upon inattention and hyperactivity/impulsivity. We then attempted replication of these findings in an independent twin cohort. METHODS Marker-trait association was analyzed by implementing the Quantitative Transmission Disequilibrium Test (QTDT). Environmental associations were tested by partial correlations. G × G were investigated by a general linear model equation and a family-based association test. G × E were analyzed through a general test for G × E in sib pair-based association analysis of quantitative traits. RESULTS DCDC2-rs793862 was associated with hyperactivity/impulsivity via G × G (KIAA0319) and G × E (miscarriage). Smoke was significantly correlated with hyperactivity/impulsivity. We replicated the DCDC2 × KIAA0319 interaction upon hyperactivity/impulsivity in the twin cohort. CONCLUSIONS DD genetic (DCDC2) and environmental factors (smoke and miscarriage) underlie ADHD traits supporting a potential pleiotropic effect.
GPU-assisted Multi-field Video Volume Visualization

GPU-assisted multi-eld rendering provides a means of generating effective video volume visualization that can convey both the objects in a spatiotemporal domain as well as the motion status of these objects. In this paper, we present a technical framework that enables combined volume and ow visualization of a video to be synthesized using GPU-based techniques. A bricking-based volume rendering method is deployed for handling large video datasets in a scalable manner, which is particularly useful for synthesizing a dynamic visualization of a video stream. We have implemented a number of image processing lter s, and in particular, we employ an optical ow lter for estimating motion ows in a video. We have devised mechanisms for combining volume objects in a scalar eld with glyph and streamline geometry from an optical ow . We demonstrate the effectiveness of our approach with example visualizations constructed from two benchmarking problems in computer vision.
Synchronization of a Novel Hyperchaotic Complex-Variable System Based on Finite-Time Stability Theory

In this paper, we investigate the finite-time synchronization problem of a novel hyperchaotic complex-variable system which generates 2-, 3- and 4-scroll attractors. Based on the finite-time stability theory, two control strategies are proposed to realize synchronization of the novel hyperchaotic complex-variable system in finite time. Finally, two numerical examples have been provided to illustrate the effectiveness of the theoretical analysis.
Melatonin Improves the Quality of Inferior Bovine Oocytes and Promoted Their Subsequent IVF Embryo Development: Mechanisms and Results

The inferior oocytes (IOs), which are not suitable for embryo development, occupy roughly one-third or more of the collected immature bovine oocytes. The IOs are usually discarded from the in vitro bovine embryo production process. Improving the quality of the inferior oocytes (IOs) and make them available in in vitro embryo production would have important biological, as well as commercial, value. This study was designed to investigate whether melatonin could improve the quality of IOs and make them usable in the in vitro maturation (IVM) and subsequent (in vitro fertilization) IVF embryo development. The results indicated that: the maturation rate of IOs and their subsequent IVF embryo developments were impaired compared to cumulus-oocyte complexes and melatonin treatment significantly improved the quality of IOs, as well as their IVF and embryo developments. The potential mechanisms are that: (1) melatonin reduced reactive oxygen species (ROS) and enhanced glutathione (GSH) levels in the IOs, thereby protecting them from oxidative stress; (2) melatonin improved mitochondrial normal distribution and function to increase ATP level in IOs; and (3) melatonin upregulated the expression of ATPase 6, BMP-15, GDF-9, SOD-1, Gpx-4, and Bcl-2, which are critical genes for oocyte maturation and embryo development and downregulated apoptotic gene expression of caspase-3.
Resonant Varifocal Micromirror with Piezoresistive Focus Sensor

This paper reports a microelectromechanical systems (MEMS) resonant varifocal mirror integrated with piezoresistive focus sensor. The varifocal mirror is driven electrostatically at a resonant frequency of a mirror plate to obtain the wide scanning range of a focal length. A piezoresistor is used to monitor the focal length of the varifocal mirror. The device is made of a silicon-on-insulator (SOI) wafer and a glass wafer. A mirror plate and a counter electrode are fabricated by a top silicon layer of the SOI wafer and on the glass wafer, respectively. The piezoresistor is fabricated by ion implantation on a supporting beam of the mirror plate. The stress variation of the beam, which is detected by the piezoresistor, correspond the focal length of the varifocal mirror. The focus length varies from −41 to 35 mm at the resonant frequency of 9.5 kHz. The focal length of the varifocal mirror is monitored by the piezoresistor in real time.
Raciocínio condicional: influências pragmáticas

Conditional declarations with the same syntactic form but different contents may take to completely different conclusions. This point has been highlighted by some researchers (e.g., Wason) as evidence of the inability of the human mind to understand the conditional sentences. In the present article, we discuss the importance of being considered the pragmatic influences in the daily conditional reasoning; because, differently of the logical reasoning, the daily reasoning does not happen in "a vacuum", but inserted in a context where the pragmatic influences occur. Initially, we introduce some precepts of the formal logic for the conditional reasoning. Next, we present the interpretation of the conditional sentences in the natural language. Some empiric evidences for the influence of pragmatic factors in the conditional reasoning will also be discussed. Finally, we consider the "theory of if" proposed by Braine and O'Brien that establishes a connection between the mental and pragmatic logic in the daily reasoning.
of the 23 rd Annual EMBS International Conference , October 25-28 , Istanbul , Turkey PSYCHOPHYSIOLOGICAL CHANGES BY NAVIGATION IN A VIRTUAL REALITY

We examined the psychophysiological effects of navigation in a virtual reality (VR). Subjects were exposed to the VR, and required to detect specific objects. Ten electrophysiological signals were recorded before, during, and after navigation in the VR. Six questionnaires on the VR experience were acquired from 45 healthy subjects. There were significant changes between the VR period and the preVR control period in several psychophysiological measurements. During the VR period, eye blink, skin conchetanee level, and alpha frequency of EEG were decreased but gamma wave were increased. Physiological changes associated with cybersickness included increased heart rate, eye blink, skin conductance response, and gamma wave and decreased photoplethysmogram and skin temperature. These results suggest an attentional change during VR navigation and activation of the autonomic nervous system for cybersickness. These findings would enhance our understanding for the psychophysiological changes during VR navigatiol and cybersickness. KeywordsVirtual reality, cybersickness, EEG
Performance comparison of the FXLMS, nonlinear FXLMS and leaky FXLMS algorithms in nonlinear active control applications

This paper investigates the performance of the filtered-X LMS (FXLMS) and leaky filtered-X LMS (LFXLMS) algorithms in a nonlinear system. In addition, we derive the nonlinear filtered-X LMS algorithm (NLFXLMS), which is obtained by considering the nonlinear system function for the determination of the gradient of the cost function. We show that the fact of not using the exact gradient implies in a performance reduction of the adaptive algorithm. The adaptive algorithms are examined in the context of active noise control applications, which possess nonlinear components. Through numerical simulations we discuss the capabilities of the examined adaptive algorithms.
Experiential avoidance post-trauma: Investigating predictors of traumatic stress and problematic behavior.

Experiential avoidance (EA) is the unwillingness to remain in contact with distressing thoughts, feelings, memories, and other private experiences (Hayes et al., 2004; Hayes, Strosahl, & Wilson, 1999). Although the use of EA may lead to immediate reductions in distress, prolonged use can result in problem behaviors such as substance misuse (Hayes, Wilson, Gifford, Follette, & Strosahl, 1996). Although a strong temporal relationship has yet to be established, findings suggest a possibility that EA could be a mechanism by which posttraumatic stress disorder (PTSD) symptoms are developed and maintained (Krause, Mendelson, & Lynch, 2003; Rosenthal, Polusny, & Follette, 2006; Dvorak, Arens, Kuvaas, Williams, & Kilwein, 2013). Undergraduate students (N = 107; Mage = 20) were recruited to complete self-report measures regarding EA, childhood trauma history, PTSD symptoms, and problem behaviors using an anonymous online survey. Consistent with predictions and the current literature, EA was significantly associated with childhood trauma exposure, PTSD symptoms, sexual promiscuity, and aggression in the expected directions. EA predicated PTSD symptoms and problem behaviors above and beyond childhood trauma history, strengthening the predictive model as hypothesized. Clinical and research implications are discussed.
On the Asymptotic Integration of Nonlinear Dynamic Equations

The purpose of this paper is to study the existence and asymptotic behavior of solutions to a class of second-order nonlinear dynamic equations on unbounded time scales. Four different results are obtained by using the Banach fixed point theorem, the Boyd and Wong fixed point theorem, the Leray-Schauder nonlinear alternative, and the Schauder fixed point theorem. For each theorem, an illustrative example is presented. The results provide unification and some extensions in the time scale setup of the theory of asymptotic integration of nonlinear equations both in the continuous and discrete cases.
AttitudeMiner: Mining Attitude from Online Discussions

This demonstration presents AttitudeMiner, a system for mining attitude from online discussions. AttitudeMiner uses linguistic techniques to analyze the text exchanged between participants of online discussion threads at different levels of granularity: the word level, the sentence level, the post level, and the thread level. The goal of this analysis is to identify the polarity of the attitude the discussants carry towards one another. Attitude predictions are used to construct a signed network representation of the discussion thread. In this network, each discussant is represented by a node. An edge connects two discussants if they exchanged posts. The sign (positive or negative) of the edge is set based on the polarity of the attitude identified in the text associated with the edge. The system can be used in different applications such as: word polarity identification, identifying attitudinal sentences and their signs, signed social network extraction from text, subgroup detect in discussion. The system is publicly available for download and has an online demonstration at http://clair.eecs. umich.edu/AttitudeMiner/.
Distinct manifestations of human papillomaviruses in the vagina

To clarify the pathogenic relationships between human papillomavirus (HPV) and vaginal intraepithelial neoplasia (VAIN), we examined 71 vaginal biopsy specimens by histopathology and immunohistochemistry and analyzed the presence of HPV DNA by blot hybridization at Tm − 40°C using an HPV 58 probe (PBM‐58 method). We found 27 cases of VAIN in patients with previous hysterectomy or antecedent or concomitant cervical intraepithelial neoplasia (CIN) and 44 cases of VAIN in patients without any abnormal findings on the cervix and the vulva. Histopathologically, 53 of 71 cases were graded as VAIN I and 15 and 3 cases were VAIN II and III, respectively, while 59 cases showed positivity for HPV capsid antigen by immunohistochemistry. Using the PBM‐58 method, all 71 VAIN cases harbored a single HPV type at more than 1,000 viral copies per cell. We identified 15 different types (HPV 16, 18, 30, 31, 35, 40, 42, 43, 51, 52, 53, 54, 56, 58 and 66). Furthermore, we molecularly cloned 7 novel prototypes (HPV 59, 61, 62, 64, 67, 69 and 71) from VAIN I. Our results are strongly indicative that HPVs are etiologic agents of VAIN, like in the case of CIN. The distinct manifestations of HPV infection in the vagina are discussed in comparison with those in the cervix. Int. J. Cancer 72:412–415, 1997. © 1997 Wiley‐Liss, Inc.
The Bayesian Evidence Scheme for Regularizing Probability-Density Estimating Neural Networks

Training probability-density estimating neural networks with the expectation-maximization (EM) algorithm aims to maximize the likelihood of the training set and therefore leads to overfitting for sparse data. In this article, a regularization method for mixture models with generalized linear kernel centers is proposed, which adopts the Bayesian evidence approach and optimizes the hyperparameters of the prior by type II maximum likelihood. This includes a marginalization over the parameters, which is done by Laplace approximation and requires the derivation of the Hessian of the log-likelihood function. The incorporation of this approach into the standard training scheme leads to a modified form of the EM algorithm, which includes a regularization term and adapts the hyperparameters on-line after each EM cycle. The article presents applications of this scheme to classification problems, the prediction of stochastic time series, and latent space models.