Miracle-dz/UniFAR-FTUs huggingface dataset:
Dermatological Manifestations of Postural Tachycardia Syndrome Are Common and Diverse

Background and Purpose Postural tachycardia syndrome (POTS) is a syndrome of orthostatic intolerance in the setting of excessive tachycardia with orthostatic challenge, and these symptoms are relieved when recumbent. Apart from symptoms of orthostatic intolerance, there are many other comorbid conditions such as chronic headache, fibromyalgia, gastrointestinal disorders, and sleep disturbances. Dermatological manifestations of POTS are also common and range widely from livedo reticularis to Raynaud's phenomenon. Methods Questionnaires were distributed to 26 patients with POTS who presented to the neurology clinic. They were asked to report on various characteristics of dermatological symptoms, with their answers recorded on a Likert rating scale. Symptoms were considered positive if patients answered with "strongly agree" or "agree", and negative if they answered with "neutral", "strongly disagree", or "disagree". Results The most commonly reported symptom was rash (77%). Raynaud's phenomenon was reported by over half of the patients, and about a quarter of patients reported livedo reticularis. The rash was most commonly found on the arms, legs, and trunk. Some patients reported that the rash could spread, and was likely to be pruritic or painful. Very few reported worsening of symptoms on standing. Conclusions The results suggest that dermatological manifestations in POTS vary but are highly prevalent, and are therefore of important diagnostic and therapeutic significance for physicians and patients alike to gain a better understanding thereof. Further research exploring the underlying pathophysiology, incidence, and treatment strategies is necessary.
Analysis and Designing of Proposed Intelligent Road Traffic Congestion Control System with Image Mosaicking Technique

As the problem of urban traffic congestion spreads, there is a pressing need for the introduction of advanced technology and equipment to improve the state-of-the-art of traffic control. As on date Traffic problems are increasing because of the number of vehicles are increasing by leaps and bounds beside the resources available with the current infrastructure are limited. A methodology has been obtained by Structured System Analysis to analyze the existing problem and Designing new model by using image mosaicking based Techniques . Problems were identified with current traffic control system . Beside, to analysis and design of new and effective system to solve the existing problems.
Data Model Management for Space Information Systems

The Reference Architecture for Space Information Management (RASIM) suggests the separation of the data model from software components to promote the development of flexible information management systems. RASIM allows the data model to evolve independently from the software components and results in a robust implementation that remains viable as the domain changes. However, the development and management of data models within RASIM are difficult and time consuming tasks involving the choice of a notation, the capture of the model, its validation for consistency, and the export of the model for implementation. Current limitations to this approach include the lack of ability to capture comprehensive domain knowledge, the loss of significant modeling information during implementation, the lack of model visualization and documentation capabilities, and exports being limited to one or two schema types. The advent of the Semantic Web and its demand for sophisticated data models has addressed this situation by providing a new level of data model management in the form of ontology tools. In this paper we describe the use of a representative ontology tool to capture and manage a data model for a space information system. The resulting ontology is implementation independent. Novel on-line visualization and documentation capabilities are available automatically, and the ability to export to various schemas can be added through tool plug-ins. In addition, the ingestion of data instances into the ontology allows validation of the ontology and results in a domain knowledge base. Semantic browsers are easily configured for the knowledge base. For example the export of the knowledge base to RDF/XML and RDFS/XML and the use of open source metadata browsers provide ready-made user interfaces that support both text- and facet-based search. This paper will present the Planetary Data System (PDS) data model as a use case and describe the import of the data model into an ontology tool. We will also describe the current effort to provide interoperability with the European Space Agency (ESA)/Planetary Science Archive (PSA) which is critically dependent on a common data model.
Routing in wireless ad hoc networks by analogy to electrostatic theory

In this paper we introduce a novel approach for the routing problem in wireless ad hoc networks. Our approach is based on the analogy of the routing problem to the distribution of electric field in a physical media with a given density of charges. We show that the throughput can be significantly increased by choosing routes in such a way that the traffic is spread as uniformly as possible throughout the network. Achieving this uniform spreading requires solution of a set of partial differential equations similar to Maxwell's equations in the electrostatic theory. While the main focus in the paper is on the case in which many sources communicate with a single destination, extension to the case of multiple destinations is also described.
Polychlorinated biphenyl induction of hepatocellular carcinoma in the Sprague-Dawley rat.

Male and female Sprague-Dawley rats (70 males and 70 females in the initial group) were fed a diet containing a polychlorinated biphenyl mixture (Aroclor 1260, 100 ppm for 16 months and 50 ppm for an additional 8 months) for 2 years followed by a control diet for 5 months. A control group initially consisted of 63 males and 63 females. Sequential morphologic changes were evaluated throughout the study. In the PCB-exposed group the following hepatocellular lesions developed in sequence: centrolobular cell hypertrophy at 1 month, foci of cell alteration at 3 months, areas at 6 months, neoplastic nodules at 12 months, trabecular carcinoma at 15 months, and adenocarcinoma at 24 months. In addition, simple and cystic cholangioma at 18 and 23 months, respectively, and adenofibrosis at 22 months were present. With the exception of hepatocyte hypertrophy and adenofibrosis, all lesions contained cells that were positive for gamma glutamyl transpeptidase activity. In the PCB-exposed group that was examined after 18 months, hepatocellular neoplasms were present in 95% of the 47 females and in 15% of the 46 males. Distant organ metastases did not occur and the mortality rate was not increased in the PCB exposed group. In 81 control rats examined after the 18th month, only 1 hepatocellular neoplasm (a neoplastic nodule) occurred. PCB- exposed and control rats developed simple cholangioma, cystic cholangioma and adenofibrosis; the incidence of each was greater in the PCB group. Thus, within the Sprague-Dawley rat group exposed to a diet with relatively high concentrations of Aroclor 1260 for 2 years a hepatocarcinogenic effect manifested by formation of slowly growing hepatocellular carcinomas was produced. ImagesFIGURE 1.FIGURE 2.FIGURE 3.FIGURE 4. AFIGURE 4. BFIGURE 5.FIGURE 6.FIGURE 7.FIGURE 8.FIGURE 9.FIGURE 10.FIGURE 11.FIGURE 12.FIGURE 13. AFIGURE 13. BFIGURE 13. CFIGURE 13. DFIGURE 13. EFIGURE 13. FFIGURE 13. GFIGURE 14.FIGURE 15.FIGURE 16.FIGURE 17.
LINE-1 methylation status of endogenous DNA double-strand breaks

DNA methylation and the repair of DNA double-strand breaks (DSBs) are important processes for maintaining genomic integrity. Although DSBs can be produced by numerous agents, they also occur spontaneously as endogenous DSBs (EDSBs). In this study, we evaluated the methylation status of EDSBs to determine if there is a connection between DNA methylation and EDSBs. We utilized interspersed repetitive sequence polymerase chain reaction (PCR), ligation-mediated PCR and combined bisulfite restriction analysis to examine the extent of EDSBs and methylation at long interspersed nuclear element-1 (LINE-1) sequences nearby EDSBs. We tested normal white blood cells and several cell lines derived from epithelial cancers and leukemias. Significant levels of EDSBs were detectable in all cell types. EDSBs were also found in both replicating and non-replicating cells. We found that EDSBs contain higher levels of methylation than the cellular genome. This hypermethylation is replication independent and the methylation was present in the genome at the location prior to the DNA DSB. The differences in methylation levels between EDSBs and the rest of the genome suggests that EDSBs are differentially processed, by production, end-modification, or repair, depending on the DNA methylation status.
Extension of Basic Service Set by Multihop Routing in IEEE 802 . 11 Wireless LAN Standard

In this paper, a multihop routing extension to IEEE 802.11 is presented. Multihop extension preserves the traditional single-hop networks where the service infrastructure is constructed by many access points but it also adds the flexibility of ad hoc networks where wireless transfer through mobile stations is allowed in multiple hop. Multihop extension can reduce the number of required access points and improve the throughput performance. Protocol presented is in compatible with the DCF and PCF medium access methods of IEEE 802.11 standard.
Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies

Abstract Objective To estimate the relative risk for fatal coronary heart disease associated with diabetes in men and women. Design Meta-analysis of prospective cohort studies. Data sources Studies published between 1966 and March 2005, identified through Embase and Medline, using a combined text word and MESH heading search strategy, in addition to studies from the Asia Pacific Cohort Studies Collaboration. Review methods Studies were eligible if they had reported estimates of the relative risk for fatal coronary heart disease comparing men and women with and without diabetes. Studies were excluded if the estimates were not adjusted at least for age. Results 37 studies of type 2 diabetes and fatal coronary heart disease among a total of 447 064 patients were identified. The rate of fatal coronary heart disease was higher in patients with diabetes than in those without (5.4 v 1.6%). The overall summary relative risk for fatal coronary heart disease in patients with diabetes compared with no diabetes was significantly greater among women than it was among men: 3.50, 95% confidence interval 2.70 to 4.53 v 2.06, 1.81 to 2.34. After exclusion of the eight studies that had adjusted only for age, the difference in risk between the sexes was substantially reduced but still highly significant. The pooled ratio of the relative risks (women: men) from the 29 studies with multiple adjusted estimates was 1.46 (1.14 to 1.88). Conclusions The relative risk for fatal coronary heart disease associated with diabetes is 50% higher in women than it is in men. This greater excess coronary risk may be explained by more adverse cardiovascular risk profiles among women with diabetes, combined with possible disparities in treatment that favour men.
A QoS enabled two-stage service differentiation model for the Internet

This paper presents a two-stage service differentiation model for the Internet. The proposed model is based on a novel interconnection of the Differentiated Services (DiffServ) architecture and the Resource Reservation Protocol (RSVP). Advantages of the proposed model, but also differentiations of other linking proposals are illustrated. An implementation specific method that tackles the problem of interconnecting the two mechanisms and that also ensures isolation and priority between RSVP and DiffServ is also presented. Correspondingly, the applicability and functionality of the model is demonstrated by creating a simulation model using the OPNET Modeler network simulation tool.
Audio thumbnailing in video sharing sites

This paper presents a variant of the Smith and Waterman algorithm that operates adaptively on a continuous feature space of MPEG-7 low level spectral descriptors and is capable of detecting repeating patterns (thumbnails) in audio streams that stem from shared Internet videos. The proposed method is not restricted to specific audio types and does not rely on training data. It has been studied in the context of four frequently encountered categories of audio streams, including TV shows, cover versions of music tracks, history documentaries and animal sounds. The results are encouraging and indicate that the presented scheme provides, in the general case, meaningful thumbnails and exhibits acceptable robustness with respect to audio recording quality.
ToxAlerts: A Web Server of Structural Alerts for Toxic Chemicals and Compounds with Potential Adverse Reactions

The article presents a Web-based platform for collecting and storing toxicological structural alerts from literature and for virtual screening of chemical libraries to flag potentially toxic chemicals and compounds that can cause adverse side effects. An alert is uniquely identified by a SMARTS template, a toxicological endpoint, and a publication where the alert was described. Additionally, the system allows storing complementary information such as name, comments, and mechanism of action, as well as other data. Most importantly, the platform can be easily used for fast virtual screening of large chemical datasets, focused libraries, or newly designed compounds against the toxicological alerts, providing a detailed profile of the chemicals grouped by structural alerts and endpoints. Such a facility can be used for decision making regarding whether a compound should be tested experimentally, validated with available QSAR models, or eliminated from consideration altogether. The alert-based screening can also be helpful for an easier interpretation of more complex QSAR models. The system is publicly accessible and tightly integrated with the Online Chemical Modeling Environment (OCHEM, http://ochem.eu). The system is open and expandable: any registered OCHEM user can introduce new alerts, browse, edit alerts introduced by other users, and virtually screen his/her data sets against all or selected alerts. The user sets being passed through the structural alerts can be used at OCHEM for other typical tasks: exporting in a wide variety of formats, development of QSAR models, additional filtering by other criteria, etc. The database already contains almost 600 structural alerts for such endpoints as mutagenicity, carcinogenicity, skin sensitization, compounds that undergo metabolic activation, and compounds that form reactive metabolites and, thus, can cause adverse reactions. The ToxAlerts platform is accessible on the Web at http://ochem.eu/alerts, and it is constantly growing.
Quantum horizons of the standard model landscape

The long-distance effective field theory of our Universe—the Standard Model coupled to gravity—has a unique 4D vacuum, but we show that it also has a landscape of lower-dimensional vacua, with the potential for moduli arising from vacuum and Casimir energies. For minimal Majorana neutrino masses, we find a near-continuous infinity of AdS3 × S1 vacua, with circumference ~ 20 microns and AdS3 length 4 × 1025 m. By AdS/CFT, there is a CFT2 of central charge c ~ 1090 which contains the Standard Model (and beyond) coupled to quantum gravity in this vacuum. Physics in these vacua is the same as in ours for energies between 10−1 eV and 1048 GeV, so this CFT2 also describes all the physics of our vacuum in this energy range. We show that it is possible to realize quantum-stabilized AdS vacua as near-horizon regions of new kinds of quantum extremal black objects in the higher-dimensional space—near critical black strings in 4D, near-critical black holes in 3D. The violation of the null-energy condition by the Casimir energy is crucial for these horizons to exist, as has already been realized for analogous non-extremal 3D black holes by Emparan, Fabbri and Kaloper. The new extremal 3D black holes are particularly interesting—they are (meta)stable with an entropy independent of and GN, so a microscopic counting of the entropy may be possible in the GN → 0 limit. Our results suggest that it should be possible to realize the larger landscape of AdS vacua in string theory as near-horizon geometries of new extremal black brane solutions.
A Computational Lexicon of Contemporary Hebrew

Computational lexicons are among the most important resources for natural language processing (NLP). Their importance is even greater in languages with rich morphology, where the lexicon is expected to provide morphological analyzers with enough information to enable themto correctly process intricately inflected forms. We describe the Haifa Lexicon of Contemporary Hebrew, the broadest-coverage publicly available lexicon of Modern Hebrew, currently consisting of over 20,000 entries.While other lexical resources of Modern Hebrew have been developed in the past, this is the first publicly available large-scale lexicon of the language. In addition to supporting morphological processors (analyzers and generators), which was our primary objective, thelexicon is used as a research tool in Hebrew lexicography and lexical semantics. It is open for browsing on the web and several search tools and interfaces were developed which facilitate on-line access to its information. The lexicon is currently used for a variety of NLP applications.
Motor Learning and Movement Performance: Older versus Younger Adults

Introduction: Motor skills play an important role during life span, and older adults need to learn or relearn these skills. The purpose of this study was to investigate how aging affects induction of improved movement performance by motor training. Methods: Serial Reaction Time Test (SRTT) was used to assess movement performance during 8 blocks of motor training. Participants were tested in two separate dates, 48 hours apart. First session included 8 blocks of training (blocks 1–8) and second session comprised 2 blocks (blocks 9, 10). Results: Analyses of data showed that reaction times in both online and offline learning were significantly shorter in older adults compared to younger adults (P<0.001). Young adults demonstrated both online and offline learning (P<0.001), but older adults only showed online learning (P<0.001) without offline learning (P=0.24). Discussion: The result of the current study provides evidence that the healthy older adults are able to improve their performance with practice and learn motor skill successfully in the form of online learning.
Inner Speech, Active Part of Working Memory Phonological Loop, Inactive in Dementia

This paper examines the role of inner speech in storage and retrieval of working memory phonological loop by conducting maintenance rehearsal test on eighteen elderly participants in two groups: a healthy group and a group with dementia. A Mann-Whitney U test was used to analyze the data. Through a comparison of the rehearsal manner of the two groups, it was concluded that the pattern of normal rehearsal of the healthy group was different from the pattern of patients suffering from dementia: also, the activity of working memory phonological loop in the healthy group was different from the lack of activity of working memory phonological loop in patients. That is, that subjects with dementia cannot use inner speech in the form of subvocal repetition was explained by applying the “Baddeley and Hitch” model of memory.
Degeneracies in the length spectra of metric graphs

The spectral theory of quantum graphs is related via an exact trace formula to the spectrum of the lengths of periodic orbits (cycles) on the graphs. The latter is a degenerate spectrum, and understanding its structure (i.e., finding how many different lengths exist for periodic orbits with a given period and the average number of periodic orbits with the same length) is necessary for the systematic study of spectral fluctuations using the trace formula. This is a combinatorial problem which we solve exactly for complete (fully connected) graphs with arbitrary number of vertices.
Novel EGFR inhibitors attenuate cardiac hypertrophy induced by angiotensin II

Cardiac hypertrophy is an important risk factor for heart failure. Epidermal growth factor receptor (EGFR) has been found to play a role in the pathogenesis of various cardiovascular diseases. The aim of this current study was to examine the role of EGFR in angiotensin II (Ang II)‐induced cardiac hypertrophy and identify the underlying molecular mechanisms. In this study, we observed that both Ang II and EGF could increase the phospohorylation of EGFR and protein kinase B (AKT)/extracellular signal‐regulated kinase (ERK), and then induce cell hypertrophy in H9c2 cells. Both pharmacological inhibitors and genetic silencing significantly reduced Ang II‐induced EGFR signalling pathway activation, hypertrophic marker overexpression, and cell hypertrophy. In addition, our results showed that Ang II‐induced EGFR activation is mediated by c‐Src phosphorylation. In vivo, Ang II treatment significantly led to cardiac remodelling including cardiac hypertrophy, disorganization and fibrosis, accompanied by the activation of EGFR signalling pathway in the heart tissues, while all these molecular and pathological alterations were attenuated by the oral administration with EGFR inhibitors. In conclusion, the c‐Src‐dependent EGFR activation may play an important role in Ang II‐induced cardiac hypertrophy, and inhibition of EGFR by specific molecules may be an effective strategy for the treatment of Ang II‐associated cardiac diseases.
Risk and severity of motor vehicle crashes in patients with obstructive sleep apnoea/hypopnoea

Background: Obstructive sleep apnoea/hypopnoea (OSAH) appears to be associated with an increased risk of motor vehicle crashes (MVCs). However, its impact on crash patterns, particularly the severity of crashes, has not been well described. A study was undertaken to determine whether OSAH severity influenced crash severity in patients referred for investigation of suspected sleep-disordered breathing. Methods: Objective crash data (including the nature of crashes) for 783 patients with suspected OSAH for the 3 years prior to polysomnography were obtained from provincial insurance records and compared with data for 783 age- and sex-matched controls. The patient group was 71% male with a mean age of 50 years, a mean apnoea-hypopnoea index (AHI) of 22 events/h and a mean Epworth Sleepiness Scale score of 10. Results: There were 375 crashes in the 3-year period, 252 in patients and 123 in controls. Compared with controls, patients with mild, moderate and severe OSAH had an increased rate of MVCs with relative risks of 2.6 (95% CI 1.7 to 3.9), 1.9 (95% CI 1.2 to 2.8) and 2.0 (95% CI 1.4 to 3.0), respectively. Patients with suspected OSAH and normal polysomnography (AHI 0–5) did not have an increased rate of MVC (relative risk 1.5 (95% CI 0.9 to 2.5), p = 0.21). When the impact of OSAH on MVC associated with personal injury was examined, patients with mild, moderate and severe OSAH had a substantially higher rate of MVCs than controls with relative risks of 4.8 (95% CI 1.8 to 12.4), 3.0 (95% CI 1.3 to 7.0) and 4.3 (95% CI 1.8 to 8.9), respectively, whereas patients without OSAH had similar crash rates to controls with a relative risk of 0.6 (95% CI 0.2 to 2.5). Very severe MVCs (head-on collisions or those involving pedestrians or cyclists) were rare, but 80% of these occurred in patients with OSAH (p = 0.06). Conclusion: Patients with OSAH have increased rates of MVCs, and disproportionately increased rates of MVCs are associated with personal injury.