Miracle-dz/UniFAR-FTUs huggingface dataset:
Controlling and modulating physical activity through Interaction Tempo in exergames: A quantitative empirical analysis

Childhood health issues related to sedentary behavior have risen dramatically over the last 20 years. One of the key factors in this rise is that children are increasingly spending more time on sedentary leisure activities such as game consoles and the Internet. Research turned to interactive exertion interfaces, or exergames, to try to compensate for the lack of physical activity in children and teenagers. Part of this research, especially in HCI, has focused on game design to truly guarantee that children are motivated to play with exergames and hence increase physical activity. Other research, essentially medical, has focused on determining whether these existing exergames foster sufficiently high levels of physical activity as recommended by health experts and compared to sports activity. An important part of research, which has almost not been addressed, is that of finding an automated system to control the amount of physical activity APA. Such system would ultimately allow health and physical education experts to draw intensity curves for play sessions to guarantee that children perform a healthy activity. Such system clearly needs a way to control this APA. We have defined a game system variable, dubbed Interaction Tempo, which has been empirically proven to be directly related to the APA performed by children in an exergame platform we have designed, the Interactive Slide. In this paper we define and justify what Interaction Tempo is and how it is related to the game control system. We describe two studies independent factorial designs that we have designed and undertaken with over 420 children. Our current results do not quantify the APA performed by children in an absolute manner. This will be part of future stages of our research with the support of medical experts and relating APA to Energy Expenditure. However, we have now proven that we can control and modulate the change in APA through the change in Interaction Tempo. These results provide a solid ground on which to design new exergames, as well as the underlying mechanism for developing adaptive systems that automatically control gameplay. This way the APA will always be at the level defined by physical education or health experts for the duration of a play session.
Oxide surfaces

We review the current knowledge of the geometric and electronic structure of oxide surfaces. In particular, material published during the last five years and going beyond the latest book by Henrich and Cox, Surface Science of Oxide Surfaces, is documented. In addition to the discussion of effects on and in bulk oxide single crystal samples, and in fact mainly, we also refer to work on thin oxide films epitaxially grown on metallic substrates. Surface states on oxide surfaces as well as band structure effects are discussed. Reconstruction and the local electronic structure are other aspects covered. We review experimental as well as theoretical approaches. Adsorption on oxide surfaces is an important subject covered in this review, and oxide modification by metal adsorption is also mentioned. This review was received in October 1995
Hyperbaric oxygen therapy for radiation‐induced brain necrosis in a patient with primary central nervous system lymphoma

A 45‐year‐old man who developed brain radionecrosis in the right frontal and left temporoparietal lobes after receiving whole brain radiotherapy and stereotactic radiosurgery for primary central nervous system lymphoma. Since high dose steroid treatment failed and he declined to undergo surgery, he was referred to hyperbaric oxygen (HBO) therapy. Both clinical and radiological findings improved after HBO therapy. Steroid requirements were also reduced. HBO therapy may have a potential value in treatment of brain radionecrosis. J. Surg. Oncol. 2009;100:732–735. © 2009 Wiley‐Liss, Inc.
Knowledge, Attitude and Practice regarding Snakes and Snakebite among Interns

Background: Snakebite is a global health problem associated with high morbidity and mortality. India has the highest number of deaths due to snakebites in the World with 35000-50000 dying per year according to World Health Organization (WHO). Despite having this highest burden, snakebite is still a neglected topic in the global health agenda. Objective: To assess the knowledge, attitude and practice regarding snake and snakebite among the interns of J.N. Medical College, Belagavi, Karnataka. Need for the study: Knowledge regarding snakes and snakebite among interns is very important as they are exposed to such cases in casualty and rural practice. Materials and Methods: This cross-sectional study was conducted among 150 interns of J.N. Medical College, Belagavi, Karnataka. A predesigned and pretested questionnaire was used to assess their knowledge, attitude and practice after taking written informed consent. Universal sampling method was used and each intern was a study participant. Results: Most of the study participants when shown different photographs could differentiate between venomous and nonvenomous snakes and their bite marks. Most common venomous snake to be identified was Spectacled Cobra while Common Krait was the least identified. About 90% of study subjects correctly differentiated between the pictures of venomous and nonvenomous snakebite marks. Conclusion: In the present study, majority of the participants had basic knowledge about snake identification and snakebite. All the participant knew that there is medical treatment available for snakebite and most of them were in favour of not killing the snakes. Snakebite management should be an important part of medical curriculum.
Advantages and limitations of Raman spectroscopy for molecular diagnostics: an update

Over the last decade, Raman spectroscopy has gained more and more interest in research as well as in clinical laboratories. As a vibrational spectroscopy technique, it is complementary to the also well-established infrared spectroscopy. Through specific spectral patterns, substances can be identified and molecular changes can be observed with high specificity. Because of a high spatial resolution due to an excitation wavelength in the visible and near-infrared range, Raman spectroscopy combined with microscopy is very powerful for imaging biological samples. Individual cells can be imaged on the subcellular level. In vivo tissue examinations are becoming increasingly important for clinical applications. In this review, we present currently ongoing research in different fields of medical diagnostics involving linear Raman spectroscopy and imaging. We give a wide overview over applications for the detection of atherosclerosis, cancer, inflammatory diseases and pharmacology, with a focus on developments over the past 5 years. Conclusions drawn from Raman spectroscopy are often validated by standard methods, for example, histopathology or PCR. The future potential of Raman spectroscopy and its limitations are discussed in consideration of other non-linear Raman techniques.
IoT (‘Connected Life’) and its Use in Different Applications: A Survey

IoT or Internet of Things is a technology, that uses internet for controlling electronic, mechanical, automobiles and other physical devices connected to the internet. The Internet of Things makes use of intelligently connected devices and systems to leverage data gathered by embedded sensors, actuators in machines and other physical objects. Now a day, IoT is spreading rapidly which is very useful to improve the quality of life. IoT smartly connects the things virtually to enhance the life with the help of artificial intelligence, algorithms and collection of data. Day by day, IoT Devices are becoming cheaper, smaller and powerful over time, so it is more flexible to use for different applications. IoT can include hardware components like different wearable devices, desktops, tablets, cellphones and software components like data collection, device integration, real time analytics, application and process extensions. IoT can be used for different purposes like industry, engineering and infrastructure, home and office, government and safety, health and medicine. IoT can also be used for checking air and water pollution, extreme weather, commercial farming etc. This paper focuses on IoT and its uses for different applications.
Investigation of the impact of parasitic parameters on PCB performance by hybridization of 3D quasistatic field solvers and MNA

This paper presents a hybrid approach to the investigation of the performance of printed circuit boards (PCB) by examining the impact of parasitic parameters of the board design on the efficiency of a device. First, parasitic parameters are extracted from the board layout by 3D quasistatic field solvers. Second, the corresponding equivalent circuit is constructed. Third, the extracted parasitic circuits are incorporated into functional circuit model. Finally, Modified Nodal Analysis (MNA) is used to examine a complete network. The hybridization makes it possible to vary circuit parameters and layout independently to achieve maximum system performance. Validation of the proposed method is performed by comparison of simulation results with measurements of GSM band signal amplifier.
AgPi: Agents on Raspberry Pi

The Raspberry Pi and its variants have brought with them an aura of change in the world of embedded systems. With their impressive computation and communication capabilities and low footprint, these devices have thrown open the possibility of realizing a network of things in a very cost-effective manner. While such networks offer good solutions to prominent issues, they are indeed a long way from being smart or intelligent. Most of the currently available implementations of such a network of devices involve a centralized cloud-based server that contributes to making the necessary intelligent decisions, leaving these devices fairly underutilized. Though this paradigm provides for an easy and rapid solution, they have limited scalability, are less robust and at times prove to be expensive. In this paper, we introduce the concept of Agents on Raspberry Pi (AgPi) as a cyber solution to enhance the smartness and flexibility of such embedded networks of physical devices in a decentralized manner. The use of a Multi-Agent System (MAS) running on Raspberry Pis aids agents, both static and mobile, to govern the various activities within the network. Agents can act autonomously or on behalf of a human user and can collaborate, learn, adapt and act, thus contributing to embedded intelligence. This paper describes how Tartarus, a multi-agent platform, embedded on Raspberry Pis that constitute a network, can bring the best out of the system. To reveal the versatility of the concept of AgPi, an application for a Location-Aware and Tracking Service (LATS) is presented. The results obtained from a comparison of data transfer cost between the conventional cloud-based approach with AgPi have also been included.
Self-Sensing Quartz-Crystal Cantilever for Nanometric Sensing

A self-sensing cantilever of AT-cut quartz plate was developed to achieve a high sensitivity under various environments at room temperature. The cantilevers fabricated by deep reactive ion etching with metal electrodes at the both sides have the thicknesses of 20 mum. The external force at shear- vibration direction induces the resonant frequency changes at thickness-shear vibration mode. The frequency modulation (FM) detection of thickness-shear vibration was demonstrated and the sensitivity and noise lever were investigated.
Multiple cellular proteins are recognized by the adeno‐associated virus Rep78 major regulatory protein and the amino‐half of Rep78 is required for many of these interactions

Adeno‐associated virus (AAV) encoded Rep78 is a multi‐functional protein which is required for AAV DNA replication, is able to regulate both AAV and heterologous gene expression at the transcriptional level, and appears necessary for site specific integration of AAV DNA into human chromosome 19. By comparison with the analogous replication protein of the polyomaviruses, large T antigen, it seemed likely that Rep78 would interact with cellular proteins to carry out at least some its functions. This study demonstrates that Rep78 is able to interact with multiple cellular proteins from cellular extracts as measured by West(far)‐western, coimmunoprecipitation, and Rep78‐affinity chromatography analysis. Eight cellular proteins of approximately 180, 140, 120, 95, 75, 55, 45, and 35 kDa (+/‐10%), were observed to bind Rep78 in all three assay systems. Two others, of 30 and 24 kDa, were observed in two of three assay systems. Furthermore, using truncated Rep78 proteins, it is demonstrated that the amino‐terminus is required for most Rep78‐cellular protein interactions. However, the extreme carboxy‐terminus of Rep78 was found to be all that is required for binding to the 55 kDa cellular protein.
Prevalence of Staphylococcus aureus and Lack of Its Lytic Bacteriophages in the Anterior Nares of Patients and Healthcare Workers at a Rural Clinic

Background: Nearly 30% of people in the United States are colonized with Staphylococcus aureus and 1% to 2% with methicillin-resistant Staphylococcus aureus (MRSA) in the anterior nares. However, it is not known if lytic bacteriophages against S. aureus are present in the anterior nares, and if they are, what the prevalence rate is, or if they interfere with S. aureus colonization. The aim of this study was to determine the prevalence of nasal carriage of S. aureus and MRSA and to screen for S. aureus lytic bacteriophages in healthcare environment workers and ambulatory patients. Methods: We enrolled 202 individuals into this study. The anterior nares were swabbed to isolate S. aureus, MRSA, and any lytic S. aureus bacteriophages that may be present. Putative S. aureus colonies on blood agar plates were identified using gram stain, catalase and coagulase tests, and confirmed by S. aureus-specific PCR. Presence of staphylococcal lytic bacteriophages were screened by a plaque assay technique using a methicillin-sensitive reference S. aureus strain ATCC 29213. Results: Of the 49 (24%) individuals who screened positive for S. aureus, two (1%) were positive for MRSA. None of the samples were positive for lytic bacteriophages against S. aureus. Subgroup analysis found no significant difference in the prevalence of S. aureus in the house staff compared to other healthcare environment workers or ambulatory patients of the clinic. Similarly, no significant difference in colonization was noted across the population with respect to age, sex, body mass index, or presence of diabetes mellitus. Conclusion: The prevalence of nasal carriage of S. aureus and MRSA in the studied population was 24% and 1%, respectively, similar to the rate of prevalence in the United States. The study also showed that the anterior nares do not seem to harbor lytic bacteriophages against S. aureus.
Recepteur d'Origine nantais (RON) tyrosine kinase splicing variants lacking exons 18 and 19 occur ubiquitously in lung cancer.

BACKGROUND Aberrant expression of RON, a MET family receptor tyrosine kinase, has been correlated to tumor growth and metastasis. Intense research efforts are on to target RON using small molecule tyrosine kinase inhibitors or specific antibodies. However, progress towards specific targeting of RON is hampered by a lack of understanding of the nature and number of isoforms of RON expressed by tumors. We hypothesize that formation of different isoforms via alternative splicing may be fundamental to the tumor promoting functions associated with aberrantly expressed RON in cancers. METHODS In this study, we analyzed the transcript sequence variations caused by alternative splicing in the C-terminal region of RON cDNA by PCR amplification and sequencing of five small cell lung carcinoma (SCLC) and seven non-small cell lung carcinoma (NSCLC) cell lines. RESULTS Results revealed the presence of two alternatively spliced variants, each caused by unique exon(s) deletion: a previously known transcript variant lacking exon 19 and a novel one lacking exons 18+19. The two alternatively spliced variants together with the wild-type transcript were detected in each of the 12 lung cancer cell lines analyzed. Combined loss of exons 18+19 results in an in-frame deletion of 303 nucleotides corresponding to 101 amino acids of the tyrosine kinase domain. Translation products of transcript variants lacking exons 18 and 19 are expected to dominant negatively inhibit ligand stimulated RON signaling. CONCLUSIONS The ubiquitous presence of alternatively spliced transcripts and their translation products may affect quantitative expression analysis, either by immunological or PCR methods, by interfering with estimation of normal RON, leading to exaggerated values. Besides, RON isoforms with dominant negative activities may interfere with siRNA based functional analysis of wild-type RON.
MEG responses to rippled noise and Huggins pitch reveal similar cortical representations

The onset of pitch within an ongoing noise signal evokes a particular brain activity, the pitch onset response (POR). Using whole-head MEG, PORs to iterated rippled noise (IRN) and Huggins pitch (HP), representing prototypical pitch-in-noise signals, were measured in twenty subjects during a pitch identification task (333 Hz, 400 Hz, randomized). HP and IRN yielded similar responses, lateralized to the left hemisphere and peaking about 180 ms after pitch onset. The initial phase (140 ms) showed stronger activations to 400 than to 333 Hz whereas later stages (200–300 ms) showed target vs nontarget effects. These results suggest, first, that different pitches converge into a common cortical representation and, second, that the POR encompasses various successive processing stages.
Dynamische Teilrouten zur anonymen Navigation

Um Privacy bei Location Based Services (LBS) zu gewahrleisten, muss auf Anwendungsebene verhindert werden, dass der Service Provider bei Navigationsabfragen die Pfade des Nutzers nachverfolgen kann. Gleichzeitig muss die Funktionsfahigkeit des Service erhalten bleiben. Durch Stuckelung der Route und anonyme Abfrage der Teilrouten lasst sich ein Privacy Enhanced Routing unter Einschrankung der Genauigkeit realisieren.
Pulse width modulated optical OFDM

In this paper, the PWM encoding of an optical OFDM transmission is studied and simulated. Traditional optical OFDM schemes make use of linear drivers, but the inherent nonlinear behavior of the optical emitters produce a harmful effect on the demodulated signal. PWM allows the use of nonlinear drivers, avoiding this harmful effects and increasing the efficiency of the transmission. Furthermore, synchronization is easier and can be edge-directed, taking advantage of the pulsed nature of the PWM. As OFDM samples may be considered normally distributed, nonlinear predistortions can be used to increase the BER performance. The proposed modulation is studied in terms of spectral efficiency, energy efficiency and thoroughly simulated for different parameters.
“Developmental mechanics”: Cellular patterns controlled by adhesion, cortical tension and cell division

How embryos are shaped during development has inspired the work of many, embryologists, geneticists, but also mathematicians such as Turing, and physicists. Despite the inherent complexity of the problems it tackles, developmental biology has produced one of the most spectacular conceptual achievements, demonstrating that embryos are built with conserved molecules that orchestrate pattern and morphogenesis. As the logic of development now emerges, new challenges arise, such as how tissue mechanics is controlled. Quantitative approaches and computational models are essential to predict tissue organization and cell shapes. I review briefly how physical concepts have fueled this research in the past decades.
A role for the lateral parabrachial nucleus in cardiovascular function and fluid homeostasis

The lateral parabrachial nucleus (LPBN) is located in an anatomical position that enables it to perform a critical role in relaying signals related to the regulation of fluid and electrolyte intake and cardiovascular function from the brainstem to the forebrain. Early neuroanatomical studies have described the topographic organization of blood pressure sensitive neurons and functional studies have demonstrated a major role for the LPBN in regulating cardiovascular function, including blood pressure, in response to hemorrhages, and hypovolemia. In addition, inactivation of the LPBN induces overdrinking of water in response to a range of dipsogenic treatments primarily, but not exclusively, those associated with endogenous centrally acting angiotensin II. Moreover, treatments that typically cause water intake stimulate salt intake under some circumstances particularly when serotonin receptors in the LPBN are blocked. This review explores the expanding body of evidence that underlies the complex neural network within the LPBN influencing salt appetite, thirst and the regulation of blood pressure. Importantly understanding the interactions among neurons in the LPBN that affect fluid balance and cardiovascular control may be critical to unraveling the mechanisms responsible for hypertension.
GARDENIA: A Domain-specific Benchmark Suite for Next-generation Accelerators

This paper presents the Graph Analytics Repository for Designing Next-generation Accelerators (GARDENIA), a benchmark suite for studying irregular algorithms on massively parallel accelerators. Existing generic benchmarks for accelerators have mainly focused on high performance computing (HPC) applications with limited control and data irregularity, while available graph analytics benchmarks do not apply state-of-the-art algorithms and/or optimization techniques. GARDENIA includes emerging irregular applications in big-data and machine learning domains which mimic massively multithreaded commercial programs running on modern large-scale datacenters. Our characterization shows that GARDENIA exhibits irregular microarchitectural behavior which is quite different from structured workloads and straightforward-implemented graph benchmarks.
On Representations and Integrability of Mathematical Structures in Energy-Conserving Physical Systems

In the present paper we elaborate on the underlying Hamiltonian structure of interconnected energy-conserving physical systems. It is shown that a power-conserving interconnection of port-controlled generalized Hamiltonian systems leads to an implicit generalized Hamiltonian system, and a power-conserving partial interconnection to an implicit port-controlled Hamiltonian system. The crucial concept is the notion of a (generalized) Dirac structure, defined on the space of energy-variables or on the product of the space of energy-variables and the space of flow-variables in the port-controlled case. Three natural representations of generalized Dirac structures are treated. Necessary and sufficient conditions for closedness (or integrability) of Dirac structures in all three representations are obtained. The theory is applied to implicit port-controlled generalized Hamiltonian systems, and it is shown that the closedness condition for the Dirac structure leads to strong conditions on the input vector fields.