Miracle-dz/UniFAR-FTUs huggingface dataset:
Synthesis of a helicopter full-authority controller

Nonlinear transformation theory is used to develop a full-authority trajectory controller for an autonomous helicopter. The transformation is simplified by the use of a forced singular perturbation. Overall system dynamics are separated into fast and slow reduced-order systems, each with nonlinear control. An analytical solution to inverting the slow time-scale dynamics is found through the inverse kinematics problem. The controller's performance is evaluated in terms of the controller's time-scale separation and uncertainties in the plant parameters.
A human TRPV1 genetic variant within the channel gating domain regulates pain sensitivity in rodents

Pain signals are relayed to the brain via a nociceptive system, and in rare cases, this nociceptive system contains genetic variants that can limit the pain response. Here, we questioned whether a human transient receptor potential vanilloid 1 (TRPV1) missense variant causes a resistance to noxious stimuli and, further, whether we could target this region with a cell-permeable peptide as a pain therapeutic. Initially using a computational approach, we identified a human K710N TRPV1 missense variant in an otherwise highly conserved region of mammalian TRPV1. After generating a TRPV1K710N-knockin mouse using CRISPR/Cas9, we discovered that the K710N variant reduced capsaicin-induced calcium influx in dorsal root ganglion neurons. The TRPV1K710N rodents also had less acute behavioral responses to noxious chemical stimuli and less hypersensitivity to nerve injury, while their response to noxious heat remained intact. Furthermore, blocking this K710 region in WT rodents using a cell-penetrating peptide limited acute behavioral responses to noxious stimuli and returned pain hypersensitivity induced by nerve injury to baseline levels. These findings identify K710 TRPV1 as a discrete site that is crucial for the control of nociception and provide insights into how to leverage rare genetic variants in humans to uncover fresh strategies for developing pain therapeutics.
Functional Surface Reconstruction from Unorganized Noisy Point Clouds

ABSTRACTAs point clouds have become an important representation of objects in reverse engineering, surface reconstruction from point clouds has consequently been an active research topic over many years. In this paper a new procedure for surface reconstruction directly from point clouds is proposed. Similar to many reported works, boundary points of functional surfaces are firstly detected by the extended difference of normals operator. After the points belonging to the same functional surface are grouped by a simple algorithm, a B-spline surface is fitted to these points so as to generate an editable NURBS surface. Experimental results shown in this literature demonstrate the feasibility of the proposed method to reconstruct curved surface with high curvature.
Underscoring the F in FoMO: How does anxiety sensitivity contribute to fear of missing out?

ABSTRACT Fear of missing out (FoMO) is a prevalent phenomenon associated with a range of mental health symptoms, such as depression and anxiety. To our knowledge, the question of whether FoMO can be explained by other well-known mechanistic variables—namely, loneliness, rumination, and anxiety sensitivity (AS) – has not been previously evaluated. The current study investigated the predictive power of loneliness, rumination, and AS for explaining variance in FoMO within two independent samples of undergraduate students at a large Northeastern university. Participants completed an online battery of questionnaires. In Study 1, it was found that loneliness and rumination offered significant prediction of FoMO when AS was not considered in the model; however, when these three predictors were considered together, only AS offered significant, non-redundant prediction. Study 2 revealed that both rumination and AS offered significant prediction of FoMO, with AS offering stronger unique prediction. Such findings provide a new frame for understanding the nature of the relatively new concept of FoMO, and in particular, suggest that it may be important to consider AS and rumination in future studies.
A participatory evaluation of legal support in the context of health‐focused peer advocacy with people who are homeless in London, UK

Abstract Legal problems can be cause and consequence of ill‐health and homelessness, necessitating efforts to integrate responses to these challenges. How to respond to legal issues within the context of health services for people who are homeless is though unclear. Groundswell piloted providing legal support to peer advocates (who have current or past experience of homelessness) and clients currently homeless in addition to their health‐focused work. A participatory action‐research design evaluated the emerging programme. Groundswell staff, both researchers and those involved in service delivery, co‐led the research alongside an external researcher. Qualitative methods were used to understand the experiences of legal support. We interviewed peer advocates and volunteers (n = 8), Groundswell clients (n = 3) and sector stakeholders (n = 3). Interviews were linked to regular reflective recorded meetings (n = 7) where Groundswell staff and researchers discussed the programme and the evaluation. Data were analysed thematically. The findings focus on three themes. First, peer advocates' and clients' legal needs involve an experience of being overwhelmed by system complexity. Second, the legal support to peer advocates aided in brokering and signposting to other legal support, in the context of a supportive organisational culture. Third, support to clients can be effective, although the complexity of legal need undermines potential for sustainable responses. In conclusion, legal support for peer advocates should be developed by Groundswell and considered by other similar agencies. Legal support to people who are currently street homeless requires significant resources and so health‐focused third‐sector organisations maybe unable to offer effective support. Other modes of integration should be pursued. Findings also have implications for how the third sector relates to the government agencies implicated in the legal challenges facing people who are homeless.
Evaluating an online self-distancing intervention to promote emotional regulation and posttraumatic growth during the COVID-19 pandemic

ABSTRACT Objectives Three online studies were conducted to elucidate the role of emotional regulation (ER) in posttraumatic growth (PTG), evaluate the ability of an online self-distancing intervention to achieve ER, and test whether increasing the use of ER strategies promotes PTG. Design Cross-sectional (Study 1) and longitudinal randomized controlled trials (RCT) (Studies 2 and 3). Method In Study 1, 626 adults completed measures of ER, PTG, and psychosocial functioning during the COVID-19 pandemic. In Study 2, 149 adults participated in a five-week RCT comparing self-immersed, spatially self-distanced, and temporally self-distanced reflection in their ability to regulate negative affect. In Study 3, 117 adults replicated the RCT of Study 2 and completed the measures from Study 1 a week pre- and post-intervention. Results Path analyses confirmed that ER strategies were relevant to COVID-19-related PTG. MANOVAs revealed that self-distancing was effective in regulating state negative affect. However, ANOVAs suggest that this was not due to increased use of ER strategies and did not improve PTG or psychosocial functioning. Conclusions These findings support further research into the relevance of ER to PTG, and provide a foundation to understand PTG and develop PTG-promoting interventions within a broader stress-coping framework.
Relationships of Low Cognitive Performance and Sleep Disorder With Functional Disabilities Among Older Adults

Objectives This study examined the relationships of low cognitive performance and sleep disorder with functional disabilities among older adults. Methods: NHANES 2011–2014 data on 3179 individuals [Mage=69.71] were analyzed. Functional domains included: activities of daily living (ADL), instrumental ADL (IADL) and leisure and social activities (LSA). Animal Fluency Test and the Digit Symbol Substitution Test assessed cognitive performance. Participants self-reported having physician-diagnosed sleep disorder. Results: Participants with both low cognitive performance and sleep disorder had 4- to 10-times greater odds for ADL, IADL, and LSA difficulties compared to the participants with no low cognitive performance/sleep disorder. Participants with only low cognitive performance and those with only sleep disorder were two to three times more likely to experience these difficulties. Discussion: Low cognitive performance and sleep disorder together or independently were associated with functional disabilities. Participants with both low cognitive performance and sleep disorder had higher odds of functional disabilities.
Circulation of Ngari Virus in Livestock, Kenya

Surveillance of vectors and hosts for infection with zoonotic arthropod-borne viruses is important for early detection and intervention measures to prevent outbreaks. Here, we report the undetected circulation of Ngari virus (NRIV) in apparently healthy cattle, sheep, and goats in Kenya. ABSTRACT Ngari virus (NRIV) is a mosquito-borne reassortant orthobunyavirus that causes severe febrile illness and hemorrhagic fever in humans and small ruminants. Due to limited diagnostics and surveillance, NRIV has only been detected sporadically during Rift Valley fever virus outbreaks. Little is known on its interepidemic maintenance and geographic distribution. In this study, sera from cattle, goats, and sheep were collected through a cross-sectional survey after the rainy seasons between 2020 and 2021 in two pastoralist-dominated semiarid ecosystems, Baringo and Kajiado counties in Kenya. NRIV was detected in 11 apparently healthy animals (11/2,039, 0.54%) by RT-PCR and isolated in cell culture from seven individuals. Growth analyses displayed efficient replication in cells from sheep and humans in contrast to weak replication in goat cells. NRIV infection of a wide variety of different vector cells showed only rapid replication in Aedes albopictus cells but not in cells derived from other mosquito species or sandflies. Phylogenetic analyses of complete-coding sequences of L, M, and S segments of four viruses showed that the Kenyan sequences established a monophyletic clade most closely related to a NRIV sequence from a small ruminant from Mauritania. NRIV neutralizing reactivity in cattle, goats, and sheep were 41.6% (95% CI = 30 to 54.3), 52.4% (95% CI = 37.7 to 66.6), and 19% (95% CI = 9.7 to 33.6), respectively. This is the first detection of NRIV in livestock in Kenya. Our results demonstrate active and undetected circulation of NRIV in the three most common livestock species highlighting the need for an active one-health surveillance of host networks, including humans, livestock, and vectors. IMPORTANCE Surveillance of vectors and hosts for infection with zoonotic arthropod-borne viruses is important for early detection and intervention measures to prevent outbreaks. Here, we report the undetected circulation of Ngari virus (NRIV) in apparently healthy cattle, sheep, and goats in Kenya. NRIV is associated with outbreaks of hemorrhagic fever in humans and small ruminants. We demonstrate the isolation of infectious virus from several animals as well as presence of neutralizing antibodies in 38% of the tested animals. Our data indicate active virus circulation and endemicity likely having important implications for human and animal health.
New benzofuran neolignans with neuroprotective activity from Phyllanthodendron breynioides

Abstract A pair of undescribed dihydrobenzofuran neolignan enantiomers, (+/−)-phybrenan A (1a/1b), two new benzofuran neolignans, phybrenan B and C (2 and 3), along with four known neolignans (4 − 7) were obtained from the plants of Phyllanthodendron breynioides P. T. Li. The planar structures of all isolates were demonstrated by the analysis of detailed spectroscopic evidence (NMR, HRMS, and IR), and the absolute configurations of novel neolignans were elucidated by combined calculated and experimental ECD data analysis. The neuroprotective activities of all benzofuran neolignans against sodium nitroprusside (SNP)-induced cell death were examined in rat pheochromocytoma PC12 cells. The results exhibited that three compounds (4 − 6) possessed remarkable neuroprotective activities at 10 µM, better than the positive drug edaravone. Graphical Abstract
Experimental investigation of compact metamaterial for high efficiency mid-range wireless power transfer applications

We investigate a compact metamaterial for enhanced magnetic coupling in a resonator coupled wireless power transfer system operating at around 6.5 MHz. The metamaterial is constructed by realizing an array of three-turn spiral resonators on a thin slab. Although the metamaterial has its own loss, the experimental results show that the proposed metamaterial slab enhances the power transmission capability. The number of unit cells in the array is an important parameter, because exceeding a certain number of unit cells does not enhance the efficiency due to the loss of the slab. Furthermore, strong surface mode resonance is observed when two slabs are assembled with proper gap spacing between them. By using the optimization approach, we achieve a significant efficiency improvement at a mid-range distance. The measured efficiencies are 71.1% and 54.3% at a 0.6 and 1.0 m distance, respectively. At a 1.0 m distance, this efficiency performance corresponds to a 270% improvement compared to a case with no metamat.
Topological defect-mediated morphodynamics of active–active interfaces

Significance Morphodynamics of active interfaces in living contexts involves complex nonequilibrium interactions between two active phases and is closely related to their organization, function, survival, competition, and invasion. We show that the long-lived topological defects excited by activity display unanticipated dynamics nearby an active–active interface, leading to the cross-interface transport and sorting of topological defects, cross-interface flow vortices, and the formation and coalescence of mesoscale fingers that are able to locally trap the opposite phase. Our findings reveal that activity-driven topological defects can mediate the interfacial morphodynamics in active systems, underscoring the unique role of defects in the contexts of tissue morphogenesis, wound healing, and diseases.
A possible influence of the density of ice accretions on their heat transfer coefficient

The heat transfer coefficient of ice accretions was reported by Avila and co‐workers who found that it depends on the cloud droplet spectrum used for the accretion. In the present work, these data are re‐examined and a new parametrization of the heat transfer coefficient is proposed as a function of accreted‐ice density. Copyright © 2005 Royal Meteorological Society
Particle-in-cell simulations of fast magnetic field penetration into plasmas due to the Hall electric field

Particle‐in‐cell (PIC) simulations are used to study the penetration of magnetic field into plasmas in the electron‐magnetohydrodynamic (EMHD) regime. These simulations represent the first definitive verification of EMHD with a PIC code. When ions are immobile, the PIC results reproduce many aspects of fluid treatments of the problem. However, the PIC results show a speed of penetration that is between 10% and 50% slower than predicted by one‐dimensional fluid treatments. In addition, the PIC simulations show the formation of vortices in the electron flow behind the EMHD shock front. The size of these vortices is on the order of the collisionless electron skin depth and is closely coupled to the effects of electron inertia. An energy analysis shows that one‐half the energy entering the plasma is stored as magnetic field energy while the other half is shared between internal plasma energy (thermal motion and electron vortices) and electron kinetic energy loss from the volume to the boundaries. The amount o.
Producing fast and active Rubisco in tobacco to enhance photosynthesis

Abstract Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) performs most of the carbon fixation on Earth. However, plant Rubisco is an intrinsically inefficient enzyme given its low carboxylation rate, representing a major limitation to photosynthesis. Replacing endogenous plant Rubisco with a faster Rubisco is anticipated to enhance crop photosynthesis and productivity. However, the requirement of chaperones for Rubisco expression and assembly has obstructed the efficient production of functional foreign Rubisco in chloroplasts. Here, we report the engineering of a Form 1A Rubisco from the proteobacterium Halothiobacillus neapolitanus in Escherichia coli and tobacco (Nicotiana tabacum) chloroplasts without any cognate chaperones. The native tobacco gene encoding Rubisco large subunit was genetically replaced with H. neapolitanus Rubisco (HnRubisco) large and small subunit genes. We show that HnRubisco subunits can form functional L8S8 hexadecamers in tobacco chloroplasts at high efficiency, accounting for ∼40% of the wild-type tobacco Rubisco content. The chloroplast-expressed HnRubisco displayed a ∼2-fold greater carboxylation rate and supported a similar autotrophic growth rate of transgenic plants to that of wild-type in air supplemented with 1% CO2. This study represents a step toward the engineering of a fast and highly active Rubisco in chloroplasts to improve crop photosynthesis and growth.
A risk score for the prognosis prediction of the muscle-invasive bladder cancer patients who received gemcitabine plus cisplatin chemotherapy

To develop an individualized gene-based risk score to predict the prognosis of muscle-invasive bladder cancer (MIBC) patients who received GC regimens. We downloaded transcriptome profiling data and clinical information from the Cancer Genome Atlas (TCGA) database. We identified 1854 survival-associated genes and then constructed the risk score based on six special genes selected from the survival-associated genes. We divided patients into high-risk and low-risk groups according to the median risk score. High-risk patients have significantly poorer overall survival than low-risk patients (log-rank test chi-square = 38.08, p = 7e-10, C-index = 0.785, se = 0.032). The risk score was evaluated by Kaplan–Meier survival curve, time-dependent ROC curves, and C-index. Multivariate Cox regression and nomogram suggested that the risk score was an independent prognostic indicator. Gene set enrichment analysis indicated that the survival-associated genes were significantly enriched in immune-related terms. Among six special genes, CHPF2, TRAV26-2, and BTF3P12 were found to be immune-related genes. In conclusion, our risk score provided an indicator to predict the prognosis of MIBC patients who received GC regimens and potential immunotherapeutic targets for MIBC.
A polyvalent multiepitope protein cross-protects against Vibrio cholerae infection in rabbit colonization and passive protection models

Significance Vibrio cholerae remains a significant problem of global health. Current oral cholera vaccines (OCVs) confer over 65% protection to adults and children older than 5 y but show poor efficacy in children younger than 5 y in endemic regions. Safe and effective cholera vaccines for all age groups are needed. Here, we reported a polyvalent protein immunogen that induced broad and functional antibodies, reduced over 99% vibrio colonization of small intestines, and protected 88% of any diarrhea and 100% of severe diarrhea from O1, O139, and non-O1/non-O139 V. cholerae infection in an adult rabbit colonization model and an infant rabbit passive protection model. This cross-protective polyvalent protein and the rabbit models (adult and infant) potentially overcome hurdles in cholera vaccine development.
Effects of second-generation H1-antihistamine drugs on angiogenesis in in vivo chick chorioallantoic membrane model

Abstract Background Literature on the effects of second-generation H1-antihistamines on angiogenesis is limited. Objectives To investigate the effects of cetirizine, desloratadine, and rupatadine (second-generation H1-antihistamines commonly used in dermatology clinics) on angiogenesis in an in vivo chick chorioallantoic membrane (CAM) model. Methods The study was approved by the local ethics committee on animal experimentation. Forty fertilized specific pathogen free eggs were incubated and kept under appropriate temperature and humidity control. Drug solutions were prepared in identical concentrations by dissolving powders in phosphate-buffered saline (PBS). On the third day of the incubation, a small window was opened on the CAM and 0.1 mL desloratadine (1.5 μg/0.1 mL) in the first group, 0.1 mL cetirizine (1.5 μg/0.1 mL) in the second group, 0.1 mL rupatadine in the third group (1.5 μg/0.1 mL), and PBS (0.1 mL) in the fourth group were administered by injection. On the eighth day of incubation, the vascular structures of the CAMs were macroscopically examined and standard digital photographs were taken. The digital images were analyzed and data including mean vessel density, thickness, and number were compared between groups. p < 0.05 was considered statistically significant. Results Vessel densities were similar in the desloratadine, cetirizine, and control groups, whereas they were significantly less in the rupatadine group (p = 0.01). Furthermore, the rupatadine group had significantly lower vessel thickness and number compared with the other groups (p < 0.05 for both). Conclusions Rupatadine showed anti-angiogenic effects in the chick CAM model, compared with desloratadine and cetirizine. The anti-angiogenic effect of rupatadine could be due to its platelet-activating factor (PAF) receptor inhibition. Thus, rupatadine could be a treatment agent in pathological processes in which angiogenesis is responsible. Further studies with larger series are needed to clarify this potential.
The Analgesic Efficacy of Intraperitoneal Ropivacaine Versus Bupivacaine for Laparoscopic Cholecystectomy: a Meta-Analysis

Abstract Introduction This meta-analysis aimed to compare the analgesic efficacy of intraperitoneal ropivacaine versus bupivacaine for laparoscopic cholecystectomy. Methods We searched PubMed, EMbase, Web of Science, EBSCO, and Cochrane Library databases from inception through January 2020 and included randomized controlled trials (RCTs) evaluating the analgesic efficacy of ropivacaine versus bupivacaine for laparoscopic cholecystectomy. Results Five RCTs are included in the meta-analysis. In patients with laparoscopic cholecystectomy, ropivacaine and bupivacaine demonstrated comparable pain scores at 2 h (SMD = –0.22; 95% CI = –0.54 to 0.10; p = 0.18), 4 h (SMD = –0.16; 95% CI = –0.42 to 0.10; p = 0.22), 8 h (SMD = –0.60; 95% CI = –1.19 to –0.01; p = 0.05), and 24 h (SMD = 0.33; 95% CI = –1.19 to 1.84; p = 0.67), as well as time to first analgesic requirement (SMD = 0.10; 95% CI = –0.23 to 0.42; p = 0.56). Conclusions Intraperitoneal ropivacaine and bupivacaine have a similar analgesic efficacy for laparoscopic cholecystectomy.
The complexity of stochastic differential equations

There has been considerable interest lately in the complexity of solving stochastic differential equations, for example, can they be solved individually for each sample path. In this note we unify what several researchers have indicated, namely that the stochastic complexity depends on the Lie algebra generated by the vector fields multiplying the noises and does not depend on the drift term.