Miracle-dz/UniFAR-FTUs huggingface dataset:
Cardioprotective Action of a Novel Synthetic 19,20-EDP Analog Is Sirt Dependent

Supplemental Digital Content is Available in the Text. Abstract: Mounting evidence suggests that cytochrome P450 epoxygenase–derived metabolites of docosahexaenoic acid, called epoxydocosapentaenoic acids (EDPs), limit mitochondrial damage after cardiac injury. In particular, the 19,20-EDP regioisomer has demonstrated potent cardioprotective action. Thus, we investigated our novel synthetic 19,20-EDP analog SA-22 for protection against cardiac ischemia–reperfusion (IR) injury. Isolated C57BL/6J mouse hearts were perfused through Langendorff apparatus for 20 minutes to obtain baseline function, followed by 30 minutes of global ischemia. Hearts were then treated with vehicle, 19,20-EDP, SA-22, or SA-22 with the pan-sirtuin inhibitor nicotinamide or the SIRT3-selective inhibitor 3-(1H-1,2,3-triazol-4-yl) pyridine (3-TYP) at the start of 40 minutes reperfusion (N = 5–8). We assessed IR injury–induced changes in recovery of myocardial function, using left ventricular developed pressure and systolic and diastolic pressure change. Tissues were assessed for electron transport chain function, SIRT1 and SIRT3, optic atrophy type 1, and caspase-1. We also used H9c2 cells in an in vitro model of hypoxia/reoxygenation injury (N = 3–6). Hearts perfused with SA-22 had significantly improved postischemic left ventricular developed pressure, systolic and diastolic recovery (64% of baseline), compared with vehicle control (15% of baseline). In addition, treatment with SA-22 led to better catalytic function observed in electron transport chain and SIRT enzymes. The protective action of SA-22 resulted in reduced activation of pyroptosis in both hearts and cells after injury. Interestingly, although nicotinamide cotreatment worsened functional outcomes, cell survival, and attenuated sirtuin activity, it failed to completely attenuate SA-22–induced protection against pyroptosis, possibly indicating EDPs exert cytoprotection through pleiotropic mechanisms. In short, these data demonstrate the potential of our novel synthetic 19,20-EDP analog, SA-22, against IR/hypoxia-reoxygenation injury and justify further development of therapeutic agents based on 19,20-EDP.
SOFTWARE FOR NUTRITIONAL ASSESSMENT OF PEOPLE WITH GLUTEN-RELATED DISORDERS

In the context of complex nutrition issues, nutritional assessment software for people with gluten-related disorders can be a precious tool for professionals in the field. It could serve as a support for novice nutritionists. The purpose of this research is to develop software for the nutritional assessment of people with Gluten-related disorders (GRDs) in the Republic of Moldova, intended for nutrition students. The development of the Software followed the systemic approach of the Nutrition Care Process, which is a graphical visualization illustrating the internal and external steps and factors that influence the use of the process. The nutritional Software was developed based on the information system Embarcadero RAD Studio Alexandria Edition, having Microsoft SQL Server as a database. The developed Software offers a personalized and precise approach, taking into account the consumer's anamnesis, the results of clinical evaluations, and anthropometric parameters, but also specific biomarkers for GRDs and offering the possibility of data recording, scanning and archiving of the results obtained from the laboratories analysis sampling. The system includes functionality to monitor and evaluate client progress toward health goals, and nutrition users can effectively track progress and make appropriate adjustments.
Patient-Centered Design Method for Self-Powered and Cost-Optimized Health Monitors

The emergence of Wireless Body Area Networks (WBANs) with health monitoring capabilities has revolutionized health care. Implementing fully independent WBAN nodes is important to the long-term viability of this initiative. Regularly recharged and depletable batteries remain a significant impediment in such systems. Energy harvesting (EH) from environmentally clean sources has thus been receiving increasing attention. Nevertheless, the autonomy and optimization of existing WBAN sensor nodes have remained questionable because methods that integrate realistic usage conditions into the design process have been lacking. A plausible method is proposed to establish a framework for designing a sustainable health monitoring node in this work. A Health Monitoring Energy System (HeMeS) tool prototype is consequently developed using comprehensive analytical models and utilized to demonstrate system design space exploration for various patient types, incorporating environmental factors, electronic load activity levels, and system cost/size constraints. It is concluded that the patient-centered system design approach incorporating interactions across transducers, electronics, sensors, user environment and data duty-cycling profiles, is viable, and is in fact appealing in safeguarding truly autonomous and cost-optimal WBANs that are compatible with climate-neutral society.
Energy efficiency of N2 vibrational excitation in the spark-and-glow phases of a long-pulse air discharge at atmospheric pressure

The vibrational excitation of N2 molecules has a significant impact on plasma chemical synthesis, including nitrogen fixation and ammonia formation, by reducing the energy barrier of chemical reactions. However, experimental data for energy efficiency of N2 vibrational excitation is very rare. In this work, vibrational coherent anti-Stokes Raman scattering was applied to a 200 μs long-pulse air plasma, and the time behaviours of rotational and vibrational temperatures of N2 in two different discharge modes, namely the spark and glow modes in the long discharge pulse, were quantified. It reveals that the spark discharge produced a vibrational temperature exceeding 5000 K but with a gas temperature as low as 400 K, while the glow discharge resulted in efficient gas heating with a gas temperature as high as 3500 K and a vibrational temperature higher than 5000 K. Combined with the 0D simulation of the air plasma, it demonstrates that the energy efficiency of N2 vibrational excitation in the glow phase is about three times higher than that of the spark phase. These results provide essential inspiration for further studies of plasma chemical synthesis dominated by N2 vibrational excitation.
Machine Learning Model for Leak Detection Using Water Pipeline Vibration Sensor

Water leakage from aging water and wastewater pipes is a persistent problem, necessitating the improvement of existing leak detection and response methods. In this study, we conducted an analysis of essential features based on data collected from leak detection sensors installed at water meter boxes and water outlets of pipelines. The water pipeline data collected through the vibration sensor were preprocessed by converting it into a tabular form by frequency band and applied to various machine learning models. The characteristics of each model were analyzed, and XGBoost was selected as the most suitable leak detection model with a high accuracy of 99.79%. These systems can effectively reduce leak detection and response time, minimize water waste, and minimize economic losses. Additionally, this technology can be applied to various fields that utilize water pipes, making it widely applicable.
Controllable topological quantum phase transitions in magnetic material FeBi2Te4

Here, we report a new intrinsic magnetic topological insulator FeBi 2 Te 4 based on ﬁrst-principles calculations and it can achieve a rich topological phase under pressure modulation. In the absence of pressure, we predict that both FeBi 2 Te 4 ferromagnetic and antiferromagnetic orders are non-trivial topological insulators. Furthermore, FeBi 2 Te 4 of FM-z ordering will undergo a series of phase transitions from topological insulator to semimetals and then to trivial insulator under pressure. Finally, we further clarify and verify the fact of topological phase transitions in conjunction with low-energy eﬀective model calculations. This topological phase transition process is attributed to the synergy of the magnetic moment and the spin-orbit coupling. The unique topological properties of FeBi 2 Te 4 will be of great interest in driving the development of quantum eﬀects.
Sensing With Wireless Power and Data Transfer—Design of a Multisensor Augmented RFID

The radio frequency identification (RFID) sensors featuring simultaneous wireless power and data transfer (WPDT) have provided promising potentials for flexible sensing and communication in future industrial applications. The performance of RFID sensors regarding the number of integrated sensors and interrogation distance is constrained by the efficiency of radio frequency energy harvesting (RF-EH) and the power management techniques for efficient power utilization. This investigation presents a design methodology for multisensor augmented RFID sensor focusing on the RF-EH efficiency, power management, and the system’s overall performance. The contributions include: 1) a multisensor augmented RFID design scheme to improve the efficiency of RF-EH and power utilization; 2) design of a planar inverted-F antenna (PIFA) and a differential feed Greinacher rectifier to improve the RF-EH efficiency; and 3) a power management optimization method to improve the power utilization efficiency based on the budgeting and analysis of the components’ consumption. A prototype system integrating temperature, humidity, and illuminance sensors is developed and experimentally verified. The presented techniques are proven a good reference for the research and practice of power-efficient sensing.
Effect of Smartphone Use on Sleep in Undergraduate Medical Students: A Cross-Sectional Study

Smartphone use, particularly at night, has been shown to provoke various circadian sleep–wake rhythm disorders such as insomnia and excessive daytime tiredness. This relationship has been mainly scrutinized among patient groups with higher rates of smartphone usage, particularly adolescents and children. However, it remains obscure how smartphone usage impacts sleep parameters in adults, especially undergraduate college students. This study sought to (1) investigate the association between smartphone use (actual screen time) and four sleep parameters: Pittsburgh sleep quality score (PSQI), self-reported screen time, bedtime, and rise time; (2) compare the seven PSQI components between good and poor sleep quality subjects. In total, 264 undergraduate medical students (aged 17 to 25 years) were recruited from the Government Doon Medical College, Dehradun, India. All participants completed a sleep questionnaire, which was electronically shared via a WhatsApp invitation link. Hierarchical and multinomial regression analyses were performed in relation to (1) and (2). The average PSQI score was 5.03 ± 0.86, with approximately one in two respondents (48.3%) having a poor sleep index. Smartphone use significantly predicted respondents’ PSQI score (β = 0.142, p = 0.040, R2 = 0.027), perceived screen time (β = 0.113, p = 0.043, R2 = 343), bedtime (β = 0.106, p = 0.042, R2 = 045), and rise time (β = 0.174, p = 0.015, R2 = 0.028). When comparing poor-quality sleep (PSQI ≥ 5) to good-quality sleep (PSQI < 5), with good-quality sleep as the reference, except sleep efficiency and sleep medications (p > 0.05), five PSQI components declined significantly: subjective sleep quality (β = −0.096, p < 0.001); sleep latency (β = −0.034, p < 0.001); sleep duration (β = −0.038, p < 0.001); sleep disturbances (β = 1.234, p < 0.001); and sleep dysfunction (β = −0.077, p < 0.001). Consequently, public health policymakers should take this evidence into account when developing guidelines around smartphone use—i.e., the when, where, and how much smartphone use—to promote improved sleep behaviour and reduce the rate of sleep–wake rhythm disorders.
Impact Of Emission Uniformity On Nutrients Uptake And Water And Fertilizers Use Efficiency By Drip Irrigated 15 Years Old Washington Novel Orange Trees Grown On A Newly Reclaimed Sandy Area.

A two successive years (2008- 2009) completely randomized field experiment with four replications on � 15 years old Washington novel orange trees was conducted in a drip irrigated newly reclaimed sandy area at Wadi El- Mollak, Ismailia governorate. Field emission uniformity (Eu) and absolute field emission uniformity (Eua) were determined for the area under study to be 85.6% for Eu and 86.8% for Eua. The irrigation system at the studied area could be considered as good. Although the uniformity of irrigation at the area under sandy has exceeded 85%, great differences were estimated between the discharge of the drippers that adversely affected the uniformity of growth, nutrients uptake, yield and both water and fertilizers use efficiency by the trees. With this respect, differences among the annual amounts of irrigation water received by the trees and consequently fertilizers dissolved in it have reached 43.1%. accordingly, significant variations were calculated to be 27.8% for leaf area, 26.7% for the dry weight of the leaves and 40.6% for obtained yield. Content of nutrients in the leaves of trees that received the maximum amount of irrigation water were higher than those of trees that received the minimum amounts by 18.3, 22.0, 25.8, 18.4 and 30.4% for N, P, K, Ca and Mg, respectively. Consequently, relative uptake of these nutrient took the same trend. Positive differences in this parameter were 45.3, 49.0, 51.8, 46.6 and 56.4% for the aforementioned nutrients, respectively. Values of water and fertilizers use efficiency by the trees were also greatly affected by the uniformity of irrigation. Higher amounts of irrigation water and applied fertilizers adversely affected both parameters. Improving the uniformity of emission of the trickle irrigation system to be more than 90% will lead to uniform fertigation. Uniform production (quantity and quality of fruits for each tree) is expected. (Journal of American Science 2010; 6(7):113-119). (ISSN: 1545-1003).
Lidar observations of the tropospheric aerosol structures on the Baikal Lake coast

In the period from 2010 to 2021, in the village of Boyarsky on the eastern coast of Baikal Lake, studies were carried out on the vertical structure of aerosol fields in the troposphere. The measurements were carried out using the LOSA-M2 aerosol-Raman lidar in the summer (July - August). A total of 93 cycles of daily observations were carried out during this period. The report presents typical patterns of transformation of aerosol layers under various synoptic conditions. Particular attention is paid in the report to the relationship between the structure of the boundary layer and the direction of movement of air masses. With a southeasterly wind prevailing at the observation site and directed along the coast, a characteristic diurnal dynamics of the boundary layer is observed with the development of a mixing layer during daytime heating of the surface. When air masses formed above the cold surface of the lake are brought in, a layered structure without pronounced updrafts prevails.
Study on charge accumulation and transient characteristics of oil paper and influence of resident charge on electric field

For studying the effect of polarity reversal electric field on the internal insulation of converter transformers, the article uses the electroacoustic pulse method as the basic principle. By measuring the space charge density at each position of oilpaper insulation under different polarity inversion times, the polarity inversion time’s influence on the oil-paper’s charge accumulation and transient characteristics is analyzed. At the same time, the electric field intensity close to the grounding electrode is obtained by integrating the charge density, and the influence of charge which is left during the inversion on the local electric field is also discussed. The research results show that as the polarity inversion time shortens, the intensity of the internal resident charge raises, which leads to the increase of the electric field intensity at the same polar voltage. In addition to that, the amplification effect of the electric field becomes more pronounced. Besides, the presence of resident charge distorts the local electric field and increases its intensity. The findings of this research have significant value in guiding for elucidating the spatial charge distribution characteristics of oil-paper insulation with the effect of the reversal of the polarity of the electric field and the impacting mechanism of resident charge on insulation degradation.
NRC's Methodology to Estimate Fuel Dispersal During a Large Break Loss of Coolant Accident

Recent experimental findings indicate that under certain transient conditions, high-burnup fuel operating at sufficiently high power can fragment and escape from burst fuel cladding, as discussed in the Nuclear Regulatory Commission’s Research Information Letter (RIL) 2021-13. The escaped fuel fragments could subsequently be distributed throughout a reactor coolant system (RCS), potentially challenging core coolability during a loss of coolant accident (LOCA). Consequently, the NRC has developed a methodology to estimate the mass of fuel that could be dispersed during a large-break LOCA. The methodology involves several NRC-sponsored computer codes, including SCALE/Polaris for lattice physics, PARCS/PATHS for full-core neutronics, TRACE for core and RCS thermal hydraulics, and FAST for steady-state and transient fuel performance calculations. Output from FAST is combined with the models in RIL 2021-13 to estimate fuel dispersal to the coolant. NRC staff have exercised this methodology using a prospective Westinghouse four loop core design with high burnup and extended enrichment that was obtained from the Department of Energy’s NEAMS program. Results demonstrate that the NRC methodology can be exercised to provide fuel dispersal estimates that can subsequently be used to study the potential consequences of FFRD. However, this exercise has also identified several areas for improvements to both the codes and to the modeling approaches used here, including the pin power reconstruction methods in PARCS, the modeling approach used to connect the Cartesian and cylindrical vessel components in TRACE, transient fission gas release and fuel rod upper plenum models in FAST, and tighter coupling between FAST and TRACE.
NEW OUTCROP AND SUBSURFACE DATA IN THE TERTIARY PIEDMONT BASIN (NW-ITALY): UNCONFORMITY-BOUNDED STRATIGRAPHIC UNITS AND THEIR RELATIONSHIPS WITH BASIN-MODIFICATION PHASES

This paper deals with the regional stratigraphy around the Alps-Apennines junction during late Eocene-Miocene. The basin-fill architecture and its relation to changes in structural style were deciphered through the integration of subsurface and outcrop data on the basis of seismic- and sequence-stratigraphy principles, respectively. During late Eocene-Oligocene, the study area hosted a mosaic of partially interconnected sub-basins, and the Torino Hill area marked the junction towards the western apex of the Southern Alps foredeep (Gonfolite Basin). Since the latest Oligocene, the uplift of the north-verging Monferrato arc provided the separation from the adjacent Gonfolite Basin and the Tertiary Piedmont Basin behaved as a larger and more regularly subsiding thrust-top basin. The upper Eocene-Miocene successions record a long-term, major transgressive-regressive cycle, consisting of seven large-scale unconformity-bounded stratigraphic units, whose stacking pattern was controlled by changes in the rate of tectonic subsidence and whose boundaries were generated by basin-modification phases. During the Oligocene-lower Miocene deepening-upward sequence set, the marginal marine systems show a marked diachronism associated with the SW-ward change of coastal onlap, punctuated by drowning-platform unconformities generated in relation to basinward tilting and high-angle synsedimentary faults. The maximum transgression coincides with the late Burdigalian tectonic space creation phase, when a basinwide, highly efficient turbidite system was deposited. The middle-upper Miocene progradation, punctuated by forced regression pulses, was driven by the inversion and uplift of the southern basin margin, so that a northward shift and progressive narrowing of the turbidite depocentre occurred.
Associations of Estradiol With Mortality and Health Outcomes in Patients Undergoing Hemodialysis: A Prospective Cohort Study

Background: Both lower and higher estradiol (E2) levels have been associated with increased mortality among women with kidney failure. However, robust data are still lacking. Objective: We investigated the interaction of diabetes and age on linear and nonlinear associations between E2 levels, adverse outcomes, and health-related quality of life (HRQOL) in Canadian women undergoing hemodialysis (HD). Design: Population-based cohort study; data from Canadian Kidney Disease Cohort Study (CKDCS). Setting & patients: A total of 427 women undergoing HD enrolled in the CKDCS. Measurements: Baseline E2 (in pmol/L) and E2 tertiles (<38 pmol/L, 38-95 pmol/L, >95 pmol/L). Methods: Cox-proportional hazards used for all-cause and cardiovascular disease (CVD) mortality. Fine-Gray models used for incident CVD. Mixed models used for Health Utilities Index Mark 3 (HUI3), Kidney Disease Quality of Life Physical Component Scores (KDQOL12-PCS), and Mental Component Scores (KDQOL12-MCS). Results: Over a median follow-up of 3.6 (interquartile range [IQR]: 1.6-7.5) years, 250 (58.6%) participants died; 74 deaths (29.6%) were CV-related. Among 234 participants without prior CV events, 80 (34.2%) had an incident CVD event. There were no significant linear associations between E2 and all-cause mortality, CVD mortality, and incident CVD. However, E2 showed a significant concave association with all-cause mortality, but not with CVD mortality and incident CVD. Among patients aged ≥63 years, higher E2 levels were associated with lower HUI3 scores, mean difference (MD) = –0.062 per 1 – SD pmol/L, 95% confidence interval (CI) = –0.112 to –0.012, but the opposite was observed in younger patients (<63 years) in whom higher E2 levels were associated with higher HUI3 scores (MD = 0.032 per 1 – SD pmol/L, 95% CI = 0.008-0.055), Pinteraction = . 045. No associations were observed among E2, KDQOL12-PCS (MD = –0.15 per 1 – SD pmol/L, 95% CI = –1.15 to 0.86), and KDQOL12-MCS (MD = –0.63 per 1 – SD pmol/L, 95% CI = –1.82 to 0.57). Limitations: Unmeasured confounding and small sample size. Conclusions: The association between E2 and all-cause mortality may be nonlinear, while no association was observed for CVD mortality, incident CVD, KDQOL12-PCS, and KDQOL12-MCS. Furthermore, the association between serum E2 and HUI3 was modified by age: Higher levels were associated with higher utility among women aged <63 years and the converse observed among older women.