Miracle-dz/UniFAR-FTUs huggingface dataset:
IBM's smart city as techno-utopian policy mobility

This paper explores IBM's Smarter Cities Challenge as an example of global smart city policymaking. The evolution of IBM's smart city thinking is discussed, then a case study of Philadelphia's online workforce education initiative, Digital On-Ramps, is presented as an example of IBM's consulting services. Philadelphia's rationale for working with IBM and the translation of IBM's ideas into locally adapted initiatives is considered. The paper argues that critical scholarship on the smart city over-emphasizes IBM's agency in driving the discourse. Unpacking how and why cities enrolled in smart city policymaking with IBM places city governments as key actors advancing the smart city paradigm. Two points are made about the policy mobility of the smart city as a mask for entrepreneurial governance. (1) Smart city efforts are best understood as examples of outward-looking policy promotion for the globalized economy. (2) These policies proposed citywide benefit through a variety of digital governance augmentations, unlike established urban, economic development projects such as a downtown redevelopment. Yet, the policy rhetoric of positive change was always oriented to fostering globalized business enterprise. As such, implementing the particulars of often-untested smart city policies mattered less than their capacity to attract multinational corporations.
The whole world is watching : mass media in the making & unmaking of the New Left : with a new preface

'The whole world is watching! ' chanted the demonstrators in the Chicago streets in 1968, as the TV cameras beamed images of police cracking heads into homes everywhere. In this classic book, originally published in 1980, acclaimed media critic Todd Gitlin first scrutinizes major news coverage in the early days of the antiwar movement. Drawing on his own experiences (he was president of the Students for a Democratic Society in 1963-64) and on interviews with key activists and news reporters, he shows in detail how the media first ignore new political developments, then select and emphasize aspects of the story that treat movements as oddities. He then demonstrates how the media glare made leaders into celebrities and estranged them from their movement base; how it inflated the importance of revolutionary rhetoric, destabilizing the movement, then promoted 'moderate' alternatives - all the while spreading the antiwar message. Finally, Gitlin draws together a theory of news coverage as a form of anti-democratic social management - which he sees at work also in media treatment of the anti-nuclear and other later movements. Updated for 2003 with a new preface, "The Whole World Is Watching" is a subtle and sensitive book, true to the passions and ironic reversals of its subject, and filled with provocative insights that apply to the media's relationship with all activist movements.
Muscle carnitine metabolism during incremental dynamic exercise in humans.

The changes in muscle content of carnitine and acetylcarnitine have been studied during incremental dynamic exercise. Six subjects exercised for 10 min on an ergometer at 40 and 75% of their maximal oxygen uptake (VO2 max) and to fatigue at 100% of VO2 max (about 4 min). Muscle samples were taken from the quadriceps femoris muscle at rest and after exercise. Muscle content of free carnitine was (means +/- SE) 15.9 +/- 1.7 mmol kg-1 d.wt (dry weight) at rest and remained unchanged after exercise at low intensity but decreased to 5.9 +/- 0.6 and 4.6 +/- 0.5 mmol kg-1 d.wt after exercise at 75 and 100% of VO2 max respectively. Acetylcarnine content at rest was 6.9 +/- 1.9 mmol kg-1 d.wt and increased during exercise in correspondence with the decrease in free carnitine. Muscle content of pyruvate and lactate was unchanged after exercise at 40% of VO2 max but increased at the higher intensities. The parallel increases in acetylcarnitine, pyruvate and lactate indicate that formation of acetylcarnitine is augmented when the availability of glycolytic three-carbon metabolites is high and is consistent with the idea that acetylcarnitine provides a sink for pyruvate and acetyl CoA. This could be of importance for the maintenance of an adequate level of CoA and thus function of the tricarboxylic acid cycle.
Making decisions in the mechanistic, probabilistic and scientific domains of medicine: a qualitative study of medical practitioners

Rationale, aims and objectives: To find out how medical practitioners perceive the processes of decision-making in the context of the individual patient and to examine the importance of decision-making in the development and identity of medical practitioners throughout their clinical lives and to suggest how these perceptions might influence medical pedagogy. Method: A qualitative study of medical practitioners of varying ages and specialties, using loosely structured biographical interviews that were read to determine the different ways in which decisions were constructed and recalled and the impact these decisions were felt to have on both the decision-maker and others for whom the decision was salient. Results: Personal decisions about career choice were important because they shaped the life of the practitioner and made a significant impact on those around them. Professional decisions were made in the domains of the mechanistic and probabilistic scientific world of medicine and in the domain of human relationships, emotions and suffering. There was often a tension between the different domains and the context of the life-world often modified decisions that might logically have been determined by evidence-based medicine and its bio-knowledge. Conclusions: Decisions had a strong effect on the development of identity within the field of practice. Individuals came to see themselves as doctors who made certain kinds of decisions of immediate relevance to the individual patient. Teaching medical students and graduates how to apply evidence to their decisions and how to use formal computational decision aids may well have a useful place in pedagogy, but the impact of decision-making on the lives of doctors and their individual patients deserves at least equal emphasis.
Optimal cross-layer scheduling for multicast in multi-channel wireless networks

We consider a generic multi-channel wireless network modeled by a hyper graph G = (V,H), where V is the set of nodes, and H is the set of broadcast links (potentially operating at different channels). Each broadcast link l ∈ H can be represented by a hyper-arc l = 〈i, J〉, with i ∈ V being the transmitter and J ⊆ H the set of intended receivers within i’s broadcast range. To model selective broadcast and variable range/rate broadcast from a transmitter, we allow one node to have multiple hyper-arcs, each of which has a different subset of intended receivers. Due to interference between adjacent transmissions, not all broadcast links can be activated simultaneously. Let ziJ be the transmission rate on link 〈i, J〉, and Ẑ be the set of rate vectors that can be scheduled at any given time. Through time sharing between different rate vectors in Ẑ , the feasible link rate region of the whole network can be characterized by the convex hull of Ẑ , Z , CH(Ẑ). For clarity of presentation, we start with a single multicast session consisting of a source s and a set of receivers T ⊆ V . We will study the multiple multicast sessions case in Section 3. For a single multicast session, we are interested in the following questions:
Online Dating in Middle and Later Life

Rising numbers of single middle-aged and older adults encouraged a proliferation of online dating websites targeting this population. However, few studies examine aging adults’ involvement in online dating. This study uses semistructured interviews with 18 online daters aged 53 to 74 and 2 romance coaches to examine how aspects of their online expectations and experiences are shaped by age and gender. Analyses reveal that men seek committed relationships, whereas women desire companionship without demanding caring roles. Different barriers to dating increase the appeal of online strategies: Men face narrow social networks, while women face competition from younger women and friendship norms limiting the pool of eligible partners. Both genders screen for youthful characteristics and attempt to convey youthful images of themselves. Men’s criteria center on physical attractiveness, whereas women’s focus is on abilities. In constructing profiles, women focus on their looks and sociability and men on their financial and occupational successes.
What is anger provoking? A psychophysical study of perceived causes of anger.

From a pool of nearly 900 situations, anonymously described by young people from prepuberty to adolescence as anger provoking, 60 situations were randomly drawn. Twelve advanced students of psychology independently rated the similarity between each possible pair of situations with respect to the perceived cause of anger. The resultant averaged similarity matrix was subjected to factor analysis, and ten factors were deemed an optimal solution, both psychologically and statistically. The factor structure is described and discussed, and other findings of situational dimensions, not made explicit by the factor analysis, are also discussed.
Who is respectful? Effects of social context and individual empathic ability on ambiguity resolution during utterance comprehension

Verbal communication is often ambiguous. By employing the event-related potential (ERP) technique, this study investigated how a comprehender resolves referential ambiguity by using information concerning the social status of communicators. Participants read a conversational scenario which included a minimal conversational context describing a speaker and two other persons of the same or different social status and a directly quoted utterance. A singular, second-person pronoun in the respectful form (nin/nin-de in Chinese) in the utterance could be ambiguous with respect to which of the two persons was the addressee (the “Ambiguous condition”). Alternatively, the pronoun was not ambiguous either because one of the two persons was of higher social status and hence should be the addressee according to social convention (the “Status condition”) or because a word referring to the status of a person was additionally inserted before the pronoun to help indicate the referent of the pronoun (the “Referent condition”). Results showed that the perceived ambiguity decreased over the Ambiguous, Status, and Referent conditions. Electrophysiologically, the pronoun elicited an increased N400 in the Referent than in the Status and the Ambiguous conditions, reflecting an increased integration demand due to the necessity of linking the pronoun to both its antecedent and the status word. Relative to the Referent condition, a late, sustained positivity was elicited for the Status condition starting from 600 ms, while a more delayed, anterior negativity was elicited for the Ambiguous condition. Moreover, the N400 effect was modulated by individuals' sensitivity to the social status information, while the late positivity effect was modulated by individuals' empathic ability. These findings highlight the neurocognitive flexibility of contextual bias in referential processing during utterance comprehension.
Omalizumab decreases IgE production in patients with allergic (IgE-mediated) asthma; PKPD analysis of a biomarker, total IgE.

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT Omalizumab is a humanized anti-IgE monoclonal antibody that binds and captures circulating IgE, preventing interaction with receptors on mast cells and basophils, thereby interrupting the allergic cascade. It has a well-characterized efficacy and safety profile in patients with asthma. While omalizumab is known to reduce serum free IgE concentrations, effects on total IgE and IgE production are less well characterized. WHAT THIS STUDY ADDS (i) Confirmation of prior hypotheses that IgE production can decrease with time when patients are given anti-IgE therapy; (ii) guidance on a biomarker, total IgE, which can be used to ascertain whether individual patients experience a change in their IgE production; and (iii) a way to assess whether patients' IgE production has been sufficiently down-regulated such that they may consider stopping anti-IgE therapy. AIM To determine whether excessive IgE production by patients with atopic allergic asthma decreases with omalizumab therapy. METHODS Omalizumab, free and total IgE data were obtained from an epidemiological study and six randomized, double-blind, placebo-controlled trials in patients with allergic asthma. The binding between omalizumab and IgE together with the production and elimination of IgE were modelled as previously, except that, in order to explain why total IgE was decreasing over a period of 5 years, the expression of IgE was allowed to change. RESULTS The prior constant IgE production model failed to converge on the data once long-term observations were included, whereas models allowing IgE production to decrease fitted. A feedback model indicated that, on average, IgE production decreased by 54% per year. This model was further developed with covariate searches indicating clinically small but statistically significant effects of age, gender, body mass index and race on some parameters. Model predictions were checked internally and externally against 3-5 year data from paediatric and adult atopic asthmatic patients and externally against extensive total IgE data from a long-duration (>1 year) phase 1 study which was not used in the model building. CONCLUSIONS A pharmacokinetic-pharmacodynamic model incorporating omalizumab-IgE binding and feedback for control of IgE production indicates that omalizumab reduces production of IgE. This raises the possibility that indefinite treatment may not be required, only for perhaps a few years. After the initial accumulation, total IgE should provide a means to monitor IgE production and guide individual treatment decisions.
biologically-determined ability are reviewed: the presence of evolutionary precursors of arithmetic in animals; the early emergence of arithmetic competence in infants independently

Précis of " The number sense " Stanislas Dehaene INSERM U.334 Abstract " Number sense " is a shorthand for our ability to quickly understand, approximate, and manipulate numerical quantities. My hypothesis is that number sense rests on cerebral circuits that have evolved specifically for the purpose of representing basic arithmetic knowledge. Four lines of evidence suggesting that number sense constitutes a domain-specific, biologically-determined ability are reviewed: the presence of evolutionary precursors of arithmetic in animals; the early emergence of arithmetic competence in infants independently of other abilities, including language; the existence of a homology between the animal, infant, and human adult abilities for number processing ; and the existence of a dedicated cerebral substrate. In adults of all cultures, lesions to the inferior parietal region can specifically impair number sense while leaving the knowledge of other cognitive domains intact. Furthermore, this region is demonstrably activated during number processing. I postulate that higher-level cultural developments in arithmetic emerge through the establishment of linkages between this core analogical representation (the " number line ") and other verbal and visual representations of number notations. The neural and cognitive organization of those representations can explain why some mathematical concepts are intuitive, while others are so difficult to grasp. Thus, the ultimate foundations of mathematics rests on core representations that have been internalized in our brains through evolution.
Euler characteristics for Gaussian fields on manifolds

We are interested in the geometric properties of real-valued Gaussian random fields defined on manifolds. Our manifolds, M, are of class C3 and the random fields f are smooth. Our interest in these fields focuses on their excursion sets, f−1[u,+∞), and their geometric properties. Specifically, we derive the expected Euler characteristic \Ee[χ(f−1[u,+∞))] of an excursion set of a smooth Gaussian random field. Part of the motivation for this comes from the fact that \Ee[χ(f−1[u,+∞))] relates global properties of M to a geometry related to the covariance structure of f. Of further interest is the relation between the expected Euler characteristic of an excursion set above a level u and \Pp[supp∈Mf(p)≥u]. Our proofs rely on results from random fields on \Rrn as well as differential and Riemannian geometry.
Gender and wellbeing among older people: evidence from Thailand

Researchers and international organisations frequently suggest that older women are disadvantaged in comparison with older men. This analysis of census and survey data from Thailand, however, indicates a far more complex association between gender and various aspects of ageing. Through an examination of various demographic, economic, psychosocial and health variables, it is found that older Thai women do face certain disadvantages compared to their male counterparts, including lower education and literacy, far higher levels of widowhood and living alone, and a lower likelihood of receiving formal retirement benefits. Older Thai men, however, also face relative disadvantages, including worse survivorship, a lower likelihood of receiving money from adult children, a greater probability of debt and other financial problems, and lower satisfaction with their financial situation. Many other demographic, psychosocial and economic measures are not significantly associated with gender. Our analysis provides some support for a lifecourse perspective, that relates gender differences in old age to differences in earlier life experiences, roles and reward structures, particularly access to retirement pensions and the type of support older men and women provide for their co-resident children. Marital status often mediates gender differences in wellbeing among older people. The study concludes with research and policy recommendations.
Mammalian genome evolution as a result of epigenetic regulation of transposable elements

Abstract Transposable elements (TEs) make up a large proportion of mammalian genomes and are a strong evolutionary force capable of rewiring regulatory networks and causing genome rearrangements. Additionally, there are many eukaryotic epigenetic defense mechanisms able to transcriptionally silence TEs. Furthermore, small RNA molecules that target TE DNA sequences often mediate these epigenetic defense mechanisms. As a result, epigenetic marks associated with TE silencing can be reestablished after epigenetic reprogramming – an event during the mammalian life cycle that results in widespread loss of parental epigenetic marks. Furthermore, targeted epigenetic marks associated with TE silencing may have an impact on nearby gene expression. Therefore, TEs may have driven species evolution via their ability to heritably alter the epigenetic regulation of gene expression in mammals.
Exploring Opportunities to Facilitate Serendipity in Search

Serendipitously discovering new information can bring many benefits. Although we can design systems to highlight serendipitous information, serendipity cannot be easily orchestrated and is thus hard to study. In this paper, we deployed a working search engine that matched search results with Facebook 'Like' data, as a technology probe to examine naturally occurring serendipitous discoveries. Search logs and diary entries revealed the nature of these occasions in both leisure and work contexts. The findings support the use of the micro-serendipity model in search system design.
Goal-Directed Simulation of Past and Future Events: Cognitive and Neuroimaging Approaches

Goal-directed episodic simulation, the imaginative construction of a hypothetical personal event or series of events focused on a specific goal, is essential to our everyday lives. We often imagine how we could solve a problem or achieve a goal in the future, or how we could have avoided a misstep in the past, but many of the behavioral and neural mechanisms underlying such goal-directed simulations have yet to be explored. The three papers of this dissertation investigated the neural correlates of three types of future episodic simulations in Papers 1 and 2 and examined a fourth such simulation directed at past events as an adaptive, constructive process in Paper 3. Some research has associated default network activity with internally-focused, but not with goal-directed cognition. Papers 1 and 2 of this dissertation showed that regions of the default network could form functional networks with regions of the frontoparietal control network while participants imagined solving specific problems or going through a sequence of steps necessary to achieve a personal goal. When participants imagined events they associated with actually attaining a goal, default network regions flexibly coupled with reward-processing regions, providing evidence that the default network can join forces with other networks or components thereof to support goal-directed episodic simulations. Using two distinct paradigms with both young and older adults, Paper 3 focused on episodic counterfactual simulations of how past events could have turned out differently and tested whether counterfactual simulations could affect participants’ memory of the original events. Our results revealed that episodic counterfactual simulations can act as a type of internally generated
Dissociable Neuroanatomical Correlates of Subsecond and Suprasecond Time Perception

The ability to estimate durations varies across individuals. Although previous studies have reported that individual differences in perceptual skills and cognitive capacities are reflected in brain structures, it remains unknown whether timing abilities are also reflected in the brain anatomy. Here, we show that individual differences in the ability to estimate subsecond and suprasecond durations correlate with gray matter (GM) volume in different parts of cortical and subcortical areas. Better ability to discriminate subsecond durations was associated with a larger GM volume in the bilateral anterior cerebellum, whereas better performance in estimating the suprasecond range was associated with a smaller GM volume in the inferior parietal lobule. These results indicate that regional GM volume is predictive of an individual's timing abilities. These morphological results support the notion that subsecond durations are processed in the motor system, whereas suprasecond durations are processed in the parietal cortex by utilizing the capacity of attention and working memory to keep track of time.