Miracle-dz/UniFAR-FTUs huggingface dataset:
Motor levels in high cervical spinal cord injuries: Implications for the International Standards for Neurological Classification of Spinal Cord Injury

Context/Objective: To verify the hypothesis that motor levels (ML) inferred from sensory levels in the upper cervical segments C2–C4 according to the current version of the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) are counterintuitive in cases where the most rostral myotomes C5 and C6 are graded as intact. Design: Prospective cohort study of ISNCSCI instructional course participants completing a post-test after the workshop to determine the MLs in two variants of a complete, high cervical spinal cord injury (SCI) case scenario. Both variants were based on the same ISNCSCI sensory and MLs of C2. In the first variant myotomes C5 and C6 were bilaterally graded as intact, while in variant 2 only active movements against gravity were possible (grade 3). Setting: Eight ISNCSCI instructional courses conducted during the study period from November 2012 until March 2015 in the framework of the European Multicenter Study on Human Spinal Cord Injury (EMSCI— http//emsci.org). Participants: Ninety-two clinicians from twenty-two SCI centers. Most of the attendees were physicians (58.7%) or physical therapists (33.7%) and had less than one year (44.6%) experience in SCI medicine. Interventions: Not applicable. Outcome Measure: The classification performance described as percentage of correctly determined MLs by the clinicians. Results: Variant 2 (89.13%) was significantly (P < 0.0001) better classified than variant 1 (65.76%). In variant 1 with intact myotomes at C5 and C6, C6 was incorrectly classified as the ML by the clinicians in 33.15% of all cases, whereas in variant 2 with non-intact C5 / C6 myotomes, C6 was rarely chosen (2.17%). Conclusions: Sensory level deferred MLs in the high cervical region of C2–C4 are counterintuitive whenever the most rostral cervical myotomes are intact. An adjustment of the ML definition in ISNCSCI may be needed.
A comparative study of Gaussian and non-Gaussian diffusion models for differential diagnosis of prostate cancer with in-bore transrectal MR-guided biopsy as a pathological reference

Background Although several studies have been reported on evaluating the performance of Gaussian and different non-Gaussian diffusion models on prostate cancer, few studies have been reported on the comparison of different models on differential diagnosis for prostate cancer. Purpose To compare the utility of various metrics derived from monoexponential model (MEM), biexponential model (BEM), stretched-exponential model (SEM) based diffusion-weighted imaging (DWI) and diffusion kurtosis imaging (DKI) in the differential diagnosis of prostate cancer. Material and Methods Thirty-three patients underwent magnetic resonance imaging (MRI) examination. Multi-b value and multi-direction DWIs were performed. In-bore MR-guided biopsy was performed. Apparent diffusion coefficient (ADC), pure molecular diffusion (ADCslow), pseudo-diffusion coefficient (ADCfast), perfusion fraction (f), water molecular diffusion heterogeneity index (α), distributed diffusion coefficient (DDC), non-Gaussian diffusion coefficient (MD), and mean kurtosis (MK) values were calculated and compared between cancerous and non-cancerous groups. Receiver operating characteristic (ROC) analysis was performed for all parameters and models. Results ADC, ADCslow, DDC, and MD values were significantly lower while MK value was significantly higher in prostate cancer than those of prostatitis and benign prostatic hyperplasia. ADC, ADCslow, DDC, MD, and MK could discriminate between tumor and non-tumorous lesions (area under the curve, 0.856, 0.835, 0.866, 0.918, and 0.937, respectively). MK was superior to ADC in the discrimination of prostate cancer. DKI was superior to MEM in the discrimination of prostate cancer. Conclusions Parameters derived from both Gaussian and non-Gaussian models could characterize prostate cancer. DKI may be advantageous than DWI for detection of prostate cancer.
How dietary evidence for the prevention and treatment of CVD is translated into practice in those with or at high risk of CVD: a systematic review

Abstract Objective CVD is a leading cause of mortality and morbidity, and nutrition is an important lifestyle factor. The aim of the present systematic review was to synthesise the literature relating to knowledge translation (KT) of dietary evidence for the prevention and treatment of CVD into practice in populations with or at high risk of CVD. Design A systematic search of six electronic databases (CINAHL, Cochrane, EMBASE, MEDLINE, PsycINFO and Scopus) was performed. Studies were included if a nutrition or dietary KT was demonstrated to occur with a relevant separate measureable outcome. Quality was assessed using a tool adapted from two quality checklists. Subjects Population with or at high risk of CVD or clinicians likely to treat this population. Results A total of 4420 titles and abstracts were screened for inclusion, with 354 full texts retrieved to assess inclusion. Forty-three articles were included in the review, relating to thirty-five separate studies. No studies specifically stated their aim to be KT. Thirty-one studies were in patient or high-risk populations and four targeted health professionals. Few studies stated a theory on which the intervention was based (n 10) and provision of instruction was the most common behaviour change strategy used (n 26). Conclusions KT in nutrition and dietary studies has been inferred, not stated, with few details provided regarding how dietary knowledge is translated to the end user. This presents challenges for implementation by clinicians and policy and decision makers. Consequently a need exists to improve the quality of publications in this area.
Assessing the transport rate of hyperpolarized pyruvate and lactate from the intra‐ to the extracellular space

The use of [1‐13C]pyruvate hyperpolarized by means of dynamic nuclear polarization provides a direct way to track the metabolic transformations of this metabolite in vivo and in cell cultures. The identification of the intra‐ and extracellular contributions to the 13C NMR resonances is not straightforward. In order to obtain information about the rate of pyruvate and lactate transport through the cellular membrane, we set up a method that relies on the sudden ‘quenching’ of the extracellular metabolites' signal. The paramagnetic Gd–tetraazacyclododecane triacetic acid (Gd‐DO3A) complex was used to dramatically decrease the longitudinal relaxation time constants of the 13C‐carboxylate resonances of both pyruvate and lactate. When Gd‐DO3A was added to an MCF‐7 cellular culture, which had previously received a dose of hyperpolarized [1‐13C]pyruvate, the contributions of the extracellular pyruvate and lactate signals were deleted. From the analysis of the decay curves of the 13C‐carboxylate resonances of pyruvate and lactate it was possible to extract information about the exchange rate of the two metabolites across the cellular membrane. In particular, it was found that, in the reported experimental conditions, the lactate transport from the intra‐ to the extracellular space is not much lower than the rate of lactate formation. The method reported herein is non‐destructive and it could be translated to in vivo studies. It opens a route for the use of hyperpolarized pyruvate to assess altered activity of carboxylate transporter proteins that may occur in pathological conditions. Copyright © 2016 John Wiley & Sons, Ltd.
Multi-Radio 5G Architecture for Connected and Autonomous Vehicles: Application and Design Insights

Connected and Autonomous Vehicles (CAVs) will play a crucial role in next-generation Cooperative Intelligent Transportation Systems (C-ITSs). Not only is the information exchange fundamental to improve road safety and efficiency, but it also paves the way to a wide spectrum of advanced ITS applications enhancing efficiency, mobility and accessibility. Highly dynamic network topologies and unpredictable wireless channel conditions entail numerous design challenges and open questions. In this paper, we address the beneficial interactions between CAVs and an ITS and propose a novel architecture design paradigm. Our solution can accommodate multi-layer applications over multiple Radio Access Technologies (RATs) and provide a smart configuration interface for enhancing the performance of each RAT.
Saccadic Behavior during the Response to Pure Disparity Vergence Stimuli I : General Properties

If two targets are carefully aligned so that they fall along the cyclopean axis, the required eye movement will be symmetrical with the two eyes turning equally inward or outward. When such “pure vergence stimuli” are used only a “pure vergence movement” is required, yet almost all responses include saccadic eye movements, a rapid tandem movement of the eyes. When saccades occur, they must either produce an error in the desired symmetrical response or correct an error from an asymmetrical vergence response. A series of eye movement responses to pure convergence step stimuli (4.0 deg step stimuli) were measured in 12 subjects and the occurrence, timing and amplitude of saccades was measured. Early saccades (within 400 msec of the stimulus onset) appeared in 80% to 100% of the responses. In most subjects, the first saccade increased the asymmetry of the response, taking the eyes away from the midline position. In three subjects, these asymmetry-inducing saccades brought one eye, the preferred or dominant eye, close to the target, but in the other subjects these asymmetry-inducing saccades were probably due to the distraction caused by the transient diplopic image generated by a pure vergence stimulus. While many of these asymmetry-inducing saccades showed saccade-like enhancements of vergence, they were, with the exception of two subjects, primarily divergent and did not facilitate the ongoing convergence movement. All subjects had some responses where the first saccade improved response symmetry, correcting an asymmetry brought about by unequal vergence movements in the two eyes. In five subjects, large symmetry-inducing saccades corrected an asymmetrical vergence response, bringing the eyes back to the midline (to within a few tenths of a degree).
Base Flipping in Tn10 Transposition: An Active Flip and Capture Mechanism

The bacterial Tn5 and Tn10 transposases have a single active site that cuts both strands of DNA at their respective transposon ends. This is achieved using a hairpin intermediate that requires the DNA to change conformation during the reaction. In Tn5 these changes are controlled in part by a flipped nucleoside that is stacked on a tryptophan residue in a hydrophobic pocket of the transposase. Here we have investigated the base flipping mechanism in Tn10 transposition. As in Tn5 transposition, we find that base flipping takes place after the first nick and is required for efficient hairpin formation and resolution. Experiments with an abasic substrate show that the role of base flipping in hairpin formation is to remove the base from the DNA helix. Specific interactions between the flipped base and the stacking tryptophan residue are required for hairpin resolution later in the reaction. We show that base flipping in Tn10 transposition is not a passive reaction in which a spontaneously flipped base is captured and retained by the protein. Rather, it is driven in part by a methionine probe residue that helps to force the flipped base from the base stack. Overall, it appears that base flipping in Tn10 transposition is similar to that in Tn5 transposition.
Exponential Stability Analysis and Stabilization for Continuous Time-Delay Systems With Controller Failure

In this brief, we study the problem of controller synthesis for time-delay systems with controller failures based on an input–output approach. First, the time-delay system with controller failure is modeled as an input–output form. Next, the stability condition of the system with controller failure is developed via scaled small gain theorem. Additionally, the proposed stability condition is also testified by the direct Lyapunov functional method. The merit of the proposed approach lies in its reduced conservatism, which is made possible by a new model of the investigated system, a new triangle inequality and a new Lyapunov–Krasovskii functional. The proposed stability condition is demonstrated to be less conservative than other existing results. Moreover, the problem of stabilization is further solved with admissible controller designed via convex optimizations. The effectiveness of the proposed method is also illustrated via a numerical example.
Toward Closed-Loop Control of Pneumatic Grippers During Pack-and-Deploy Operations

Soft robotic grippers can grasp objects of many different shapes while tolerating misalignments. However, many current soft systems lack proprioception and the ability to sense the position and orientation of the object to be grasped. Understanding the configuration of a gripper's fingers and the contact forces on a grasped object is crucial for manipulating an object and for interacting with the external environment. In this letter, we instrument a fabric-based pneumatic gripper with strain and pressure (force) sensors. Using sensors affixed to removable sleeves fit over each gripper finger, we identify the finger position and contact force on a grasped object. We show that we are able to completely deflate and pack the gripper, and then deploy the gripper and sensors to full operation. Finally, we demonstrate closed-loop control of the gripper configuration using the strain sensors to reconstruct pose.
Nicotine regulates cocaine‐amphetamine‐Regulated Transcript (Cart) in the mesocorticolimbic system

Cocaine‐and‐Amphetamine Regulated Transcript (CART) mRNA and peptides are intensely expressed in the brain regions comprising mesocorticolimbic system. Studies suggest that CART peptides may have a role in the regulation of reward circuitry. The present study aimed to examine the effect of nicotine on CART expression in the mesocorticolimbic system. Three different doses of nicotine (0.2, 0.4, 0.6 mg/kg free base) were injected subcutaneously for 5 days, and on day 6, rats were decapitated following a challenge dose. CART mRNA and peptide levels in medial prefrontal cortex (mPFC), nucleus accumbens (NAc), dorsal striatum (DST), amygdala (AMG), lateral hypothalamic area (LHA), and ventral tegmental area (VTA) were measured by quantitative real‐time PCR (qPCR) and Western Blot analysis, respectively. In the mPFC, 0.4 and 0.6 mg/kg nicotine, decreased CART peptide levels whereas there was no effect on CART mRNA levels. In the VTA, a down‐regulation of CART peptide expression was observed with 0.2 and 0.6 mg/kg nicotine. Conversely, 0.4 and 0.6 mg/kg nicotine increased CART mRNA levels in the AMG without affecting the CART peptide expression. Nicotine did not regulate CART mRNA or CART peptide expression in the NAc, DST, and LHA. We conclude that nicotine regulates CART expression in the mesocorticolimbic system and this regulation may play an important role in nicotine reward. Synapse 70:283–292, 2016. © 2016 Wiley Periodicals, Inc.
Successful treatment of hepatitis C virus infection with sofosbuvir and simeprevir in the early phase of an allogeneic stem cell transplant

Currently, a lack of consensus exists on how to manage a hepatitis C virus (HCV) infection after allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Ribavirin alone, or in combination with interferon, has been the mainstream therapy for HCV infection after transplantation. However, very few patients have been regularly treated owing to concerns about poor tolerability, frequent side effects, and limited efficacy. The present case illustrates the striking efficacy of the combination therapy of sofosbuvir with simeprevir, early after transplantation, as it was able to completely eliminate viral replication within 1 month of initiation of treatment. Moreover, tolerance was good, with only minor interactions between the immunosuppressive drugs. This case report supports the feasibility of using this combination therapy early after allo‐HSCT for patients with HCV infection.
Can In-Bag Manual Morcellation Represent an Alternative to Uncontained Power Morcellation in Laparoscopic Myomectomy? A Randomized Controlled Trial

Aims: The study aimed to evaluate feasibility and safety of in-bag manual morcellation compared to uncontained power morcellation during laparoscopic myomectomy. Methods: A total of 72 women undergoing laparoscopic myomectomy were randomized into 2 treatment groups: 34 patients underwent in-bag manual morcellation (experimental group) and 38 were submitted to uncontained power morcellation (control group). The primary end point was the comparison of morcellation operative time (MOT). Total operative time (TOT), rate of intraoperative complication, and postoperative outcomes in the 2 groups were regarded as secondary outcomes. Results: Mean MOT and TOT were longer in the experimental group than in the control one (MOT: 9.47 ± 5.05 vs. 6.16 ± 7.73 min; p = 0.01; TOT: 113.24 ± 28.12 vs. 96.74 ± 33.51 min; p = 0.01). No intraoperative complications occurred in either group and no cases of bag disruption or laparotomic conversion were recorded. No significant difference in hemoglobin drop, hospital stay, and postoperative outcomes was reported between groups. Conclusion: In-bag manual morcellation appears a safe and feasible procedure and, despite slightly longer operative time, could represent an alternative to uncontained power morcellation.
Fluctuation spectra and force generation in nonequilibrium systems

Significance Understanding force generation in nonequilibrium systems is a significant challenge in statistical and biological physics. We show that force generation in nonequilibrium systems is encoded in their energy fluctuation spectra. In particular, a nonequipartition of energy, which is only possible in active systems, can lead to a nonmonotonic fluctuation spectrum. For a narrow, unimodal spectrum, we find that the force exerted by a nonequilibrium system on two embedded walls depends on the width and the position of the peak in the fluctuation spectrum, and oscillates between repulsion and attraction as a function of wall separation. Our results agree with recent molecular dynamics simulations of active Brownian particles, and shed light on the old riddle of the Maritime Casimir effect. Many biological systems are appropriately viewed as passive inclusions immersed in an active bath: from proteins on active membranes to microscopic swimmers confined by boundaries. The nonequilibrium forces exerted by the active bath on the inclusions or boundaries often regulate function, and such forces may also be exploited in artificial active materials. Nonetheless, the general phenomenology of these active forces remains elusive. We show that the fluctuation spectrum of the active medium, the partitioning of energy as a function of wavenumber, controls the phenomenology of force generation. We find that, for a narrow, unimodal spectrum, the force exerted by a nonequilibrium system on two embedded walls depends on the width and the position of the peak in the fluctuation spectrum, and oscillates between repulsion and attraction as a function of wall separation. We examine two apparently disparate examples: the Maritime Casimir effect and recent simulations of active Brownian particles. A key implication of our work is that important nonequilibrium interactions are encoded within the fluctuation spectrum. In this sense, the noise becomes the signal.
Separating Named Entities

In this paper, we analyze the situation of long sequences of mostly capitalized words which look like a named entity but in fact they consist of several named entities. An example of such phenomena is hokejista (hockey player) New York Rangers Jaromir Jagr. Without splitting the sequence correctly, we will wrongly assume that the whole capitalized sequence is a name of the hockey player. To find out how the sequence should be split into the correct named entities, we tested several methods. These methods are based on the frequencies of the words they consist of and their n-grams. The method DIFF-2 proposed in this article obtained much better results than MI-score or logDice.
Energy efficient home with price sensitive stochastically programmable TCAs

Introduction of dynamic pricing in present retail market, considerably affects customers with an increased cost of energy consumption. Therefore, customers are enforced to control their loads according to price variation. This paper proposes a new technique of Home Energy Management, which helps customers to minimize their cost of energy consumption by appropriately controlling their loads. Thermostatically Controllable Appliances (TCAs) such as air conditioner and water heater are focused in this study, as they consume more than 50% of the total household energy consumption. The control process includes stochastic dynamic programming, which incorporated uncertainties in price and demand variation. It leads to an accurate selection of appliance settings. It is followed by a real time control of selected appliances with its optimal settings. Temperature set points of TCAs are adjusted based on price droop which is a reflection of actual cost of energy consumption. Customer satisfaction is maintained within limits using constraint optimization. It is showed that considerable energy savings is achieved.
Relative peak exercise oxygen pulse is related to sudden cardiac death, cardiovascular and all-cause mortality in middle-aged men

Background Preliminary evidence suggests that peak exercise oxygen pulse – peak oxygen uptake/heart rate-, a variable obtained during maximal cardiopulmonary exercise testing and a surrogate of stroke volume, is a predictor of mortality. We aimed to assess the associations of peak exercise oxygen pulse with sudden cardiac death, fatal coronary heart disease and cardiovascular disease and all-cause mortality. Design A prospective study. Methods Peak exercise oxygen pulse was assessed in a maximal cycling test at baseline in 2227 middle-aged men of the Kuopio Ischaemic Heart Disease cohort study using expired gas variables and electrocardiograms. Relative peak exercise oxygen pulse was obtained by dividing the absolute value by body weight. Results During a median follow-up of 26.1 years 1097 subjects died; there were 220 sudden cardiac deaths, 336 fatal coronary heart diseases and 505 fatal cardiovascular diseases. Relative peak exercise oxygen pulse (mean 19.5 (4.1) mL per beat/kg/102) was approximately linearly associated with each outcome. Comparing extreme quartiles of relative peak exercise oxygen pulse, hazard ratios (95% confidence intervals) for sudden cardiac death, fatal coronary heart disease and cardiovascular disease, and all-cause mortality on adjustment for cardiovascular risk factors were 0.55 (0.36–0.83), 0.58 (0.42–0.81), 0.60 (0.46–0.79) and 0.59 (0.49–0.70), respectively (P < 0.001 for all). The hazard ratios were unchanged on further adjustment for C-reactive protein and the use of beta-blockers. The addition of relative peak exercise oxygen pulse to a cardiovascular disease mortality risk prediction model significantly improved risk discrimination (C-index change 0.0112; P = 0.030). Conclusion Relative peak exercise oxygen pulse measured during maximal exercise was linearly and inversely associated with fatal cardiovascular and all-cause mortality events in middle-aged men. In addition, relative peak exercise oxygen pulse provided significant improvement in cardiovascular disease mortality risk assessment beyond conventional risk factors.