Miracle-dz/UniFAR-FTUs huggingface dataset:
A new proposal for glueball exploration in hard gluon fragmentation

An unambiguous identification of glueballs in experiments will be of great significance, because their existence is an important test of QCD. The proposal, advanced here, is to experimentally search for glueballs as peaks in the invariant mass of a leading KS-pair fragmenting from an energetic gluon jet out of high-statistics three-jet events in hadronic decays of the weak neutral Z boson. Using a physically motivated model of the gluon-glueball fragmentation function, we find a substantial fragmentation rate into a leading glueball. It is very likely that a search, along the lines suggested here by any of the four groups at the Large Electron Positron collider at CERN, will prove fruitful.
Emergent Allee effects in top predators feeding on structured prey populations

Top predators that forage in a purely exploitative manner on smaller stages of a size–structured prey population have been shown to exhibit an Allee effect. This Allee effect emerges from the changes that predators induce in the prey–population size distribution and represents a feedback of predator density on its own performance, in which the feedback operates through and is modified by the life history of the prey. We demonstrate that these emergent Allee effects will occur only if the prey, in the absence of predators, is regulated by density dependence in development through one of its juvenile stages, as opposed to regulation through adult fecundity. In particular, for an emergent Allee effect to occur, over–compensation is required in the maturation rate out of the regulating juvenile stage, such that a decrease in juvenile density will increase the total maturation rate to larger/older stages. If this condition is satisfied, predators with negative size selection, which forage on small prey, exhibit an emergent Allee effect, as do predators with positive size selection, which forage on large adult prey. By contrast, predators that forage on juveniles in the regulating stage never exhibit emergent Allee effects. We conclude that the basic life–history characteristics of many species make them prone to exhibiting emergent Allee effects, resulting in an increased likelihood that communities possess alternative stable states or exhibit catastrophic shifts in structure and dynamics.
Ovary and ovulation: A morphological and functional study of the effect of slow freezing followed by complete in-vitro maturation of primary mouse ovarian follicles

: Mechanically isolated intact early preantral follicles (100-130 microns diameter) from 14 day old mice were cryopreserved by a slow freezing protocol with dimethyl sulphoxide and then matured in vitro for 12 days after rapid thawing. Minor freeze damage observed after 1 day of in-vitro culture included ablation of the theca cell layer and granulosa cell dehydration, resulting in disruption of intercellular contacts with the oocyte and between granulosa cells. Of the follicles, 24% were irreversibly damaged and had a collapsed oocyte. The remaining majority of the follicles had an intact oocyte as evaluated by ultrastructural analysis. Follicles with an intact oocyte were cultured in vitro and, after an initial retarded development, the final number of fully grown oocytes ovulated in vitro was not different from that of unfrozen controls. Cryopreserved early preantral follicles matured in vitro responded to stimulus with human chorionic gonadotrophin in a similar way to controls, with mucification of the oocyte-cumulus complex, germinal vesicle breakdown and extrusion of the first polar body of the oocyte. These cryopreserved, in-vitro matured oocytes had the potential to fertilize and develop to hatched blastocysts.
CYP6 P450 Enzymes and ACE-1 Duplication Produce Extreme and Multiple Insecticide Resistance in the Malaria Mosquito Anopheles gambiae

Malaria control relies heavily on pyrethroid insecticides, to which susceptibility is declining in Anopheles mosquitoes. To combat pyrethroid resistance, application of alternative insecticides is advocated for indoor residual spraying (IRS), and carbamates are increasingly important. Emergence of a very strong carbamate resistance phenotype in Anopheles gambiae from Tiassalé, Côte d'Ivoire, West Africa, is therefore a potentially major operational challenge, particularly because these malaria vectors now exhibit resistance to multiple insecticide classes. We investigated the genetic basis of resistance to the most commonly-applied carbamate, bendiocarb, in An. gambiae from Tiassalé. Geographically-replicated whole genome microarray experiments identified elevated P450 enzyme expression as associated with bendiocarb resistance, most notably genes from the CYP6 subfamily. P450s were further implicated in resistance phenotypes by induction of significantly elevated mortality to bendiocarb by the synergist piperonyl butoxide (PBO), which also enhanced the action of pyrethroids and an organophosphate. CYP6P3 and especially CYP6M2 produced bendiocarb resistance via transgenic expression in Drosophila in addition to pyrethroid resistance for both genes, and DDT resistance for CYP6M2 expression. CYP6M2 can thus cause resistance to three distinct classes of insecticide although the biochemical mechanism for carbamates is unclear because, in contrast to CYP6P3, recombinant CYP6M2 did not metabolise bendiocarb in vitro. Strongly bendiocarb resistant mosquitoes also displayed elevated expression of the acetylcholinesterase ACE-1 gene, arising at least in part from gene duplication, which confers a survival advantage to carriers of additional copies of resistant ACE-1 G119S alleles. Our results are alarming for vector-based malaria control. Extreme carbamate resistance in Tiassalé An. gambiae results from coupling of over-expressed target site allelic variants with heightened CYP6 P450 expression, which also provides resistance across contrasting insecticides. Mosquito populations displaying such a diverse basis of extreme and cross-resistance are likely to be unresponsive to standard insecticide resistance management practices.
Can a Pressure Standard be Based on Capacitance Measurements?

We consider the feasibility of basing a pressure standard on measurements of the dielectric constant ϵ and the thermodynamic temperature T of helium near 0 °C. The pressure p of the helium would be calculated from fundamental constants, quantum mechanics, and statistical mechanics. At present, the relative standard uncertainty of the pressure ur(p) would exceed 20 × 10−6, the relative uncertainty of the value of the molar polarizability of helium Aϵ calculated ab initio. If the relativistic corrections to Aϵ were calculated as accurately as the classical value is now known, a capacitance-based pressure standard might attain ur(p) < 6 × 10−6 for pressures near 1 MPa, a result of considerable interest for pressure metrology. One obtains p by eliminating the density from the virial expansions for p and ϵ − 1. If ϵ − 1 were measured with a very stable, 0.5 pF toroidal cross capacitor, the small capacitance and the small values of ϵ − 1 would require state-of-the-art capacitance measurements to achieve a useful pressure standard.
Comparison between facemask and laryngeal mask airway in rabbits during isoflurane anesthesia.

OBJECTIVE To determine whether a laryngeal mask airway (LMA) provides a better airway than a facemask in spontaneously breathing anesthetized rabbits, and to test if it can be used for mechanically controlled ventilation. STUDY DESIGN Randomized prospective experimental trial. ANIMALS Sixteen young, healthy, specific pathogen-free Giant Flemish cross Chinchilla rabbits (10 females and 6 males) weighing 4.1 +/- 0.8 kg. METHODS Rabbits were assigned randomly to one of three treatment groups: facemask with spontaneous ventilation (FM-SV; n = 5), LMA with spontaneous ventilation (LMA-SV; n = 5), and LMA with controlled ventilation (LMA-CV; n = 6). In dorsal recumbency, and at 2.3% end-tidal isoflurane concentration, Fé isoflurane, Fi isoflurane, partial pressure of expired isoflurane (PECO(2)), partial pressure of inspired carbon dioxide (PiCO(2)), heart rate, respiratory rate, minute volume, arterial oxygen tensions (PaO(2)), arterial carbon dioxide tensions (PaCO(2)), arterial pH (pH(a)), arterial standard base excess (SBE(a)) values were measured for 120 minutes. Results Two individuals in the FM-SV group had PaCO(2) > 100 mm Hg. One rabbit in the FM-SV had PaO(2) < 80 mm Hg. All FM-SV rabbits showed signs of airway obstruction, and two were withdrawn from the study at 45 and 90 minutes, respectively, because cyanosis was observed. No signs of airway obstruction were observed in either LMA group. Four rabbits in the LMA-CV group developed gastric tympanism, one of which refluxed gastric contents after 110 minutes. There were no differences between FM-SV and LMA-SV in any variable tested. PaCO(2) and PECO(2) were decreased, while PaO(2) and minute volume were increased in the LMA-CV group compared to the LMA-SV group. CONCLUSIONS An LMA provided a better airway than a facemask during spontaneous breathing in rabbits, as the use of a facemask was associated with hypercapnia and low partial pressures of oxygen. Although an LMA can be used for intermittent positive pressure ventilation (IPPV), gastric tympanism may develop, especially at a peak inspiratory pressure of 14 cm H(2)O. CLINICAL RELEVANCE The LMA can be used in rabbits but further work is needed before it is applied routinely.
Semantische Form und pragmatische Anreicherung: Situationsausdrücke in der Äußerungsinterpretation

This paper is concerned with meaning variations taking place in the interpretation of utterances. In particular, it examines the phenomena of conceptual differentiation and conceptual shifting performed on expressions of situations. My point of departure is that the linguistic form drastically underdetermines the propositional content which is explicitly expressed by an utterance. Consequently, I suppose a general framework which makes a distinction between two basic phases within the process of understanding. In the first phase of interpretation, which is part of the autonomous grammatical system, the context-independent and, hence, merely formal meaning of the utterance is calculated by means of semantic composition. In the second phase its contextually specified meaning is derived by pragmatic inferences integrating the abstract meaning base with accessible elements of conceptual knowledge. In concretizing this picture, I offer a multi-level model in which the propositional content, starting from the level of semantic form, has to be elaborated step by step in a sequence of conceptual structures. In view of the fact that most verbs are open to a multitude of primary meaning variants, the paper argues for a minimalistic approach to their lexical-semantic form which allows for conceptual differentiation by fixing the parameters involved. Essentially, the strategy of radical underspecification is also applied to the problem of deviating interpretations which can be observed, for instance, in adverbial modification. My basic assumption is that in the course of compositional derivation further parameters are introduced by obligatory insertion of certain general schemata. If required, these parameters are available to a fixation by means of which a suitable conceptual shifting of the respective expression is realized.
Underestimation of breast cancer risk: influence on screening behavior.

PURPOSE/OBJECTIVES To describe perceived breast cancer risk, identify the percentage of women with inaccurate risk perceptions, and examine the influence of perceived and objective risk on screening behavior. DESIGN Descriptive, correlational, cross-sectional. SETTING Community settings in a metropolitan area on the western coast of the United States. SAMPLE Multicultural sample of 184 English-speaking women (57% non-Caucasian, X age = 47 +/- 12 years) who have never been diagnosed with cancer. METHODS Two perceived risk scales (verbal and comparative) and the Gail model were used to assess perceived and objective breast cancer risk, respectively. MAIN RESEARCH VARIABLES Perceived breast cancer risk, objective breast cancer risk, screening behavior. FINDINGS Participants reported that they "probably will not" get breast cancer and that their risk was "somewhat lower" than average. Family history of breast cancer was a significant predictor of perceived risk. Demographic characteristics and objective risk factors were not associated with perceived risk. Most women at high risk for breast cancer (89%) underestimated their actual risk; fewer women with low to average risk for breast cancer (9%) overestimated their risk. Age, Gail scores, and health insurance status promoted breast cancer screening; underestimation of risk had the opposite effect. CONCLUSIONS Inaccurate perceptions of risk do not promote optimal breast cancer screening. The finding has implications for most women at high risk for developing breast cancer who underestimate their risk. IMPLICATIONS FOR NURSING Oncology nurses can use risk assessment tools to provide individualized counseling regarding breast cancer risk factors and screening. Women at high risk who underestimate their risk could benefit from additional screening and from advances in cancer chemoprevention.
Capo: robust and scalable open-source min-cut floorplacer

In this invited note we describe Capo, an open-source software tool for cell placement, mixed-size placement and floorplanning with emphasis on routability. Capo is among the fastest academic placers and scales to millions of movable objects. This note surveys the overall structure of Capo, discusses recent improvements and describes ongoing research.
Relating Granger causality to directed information theory for networks of stochastic processes

This paper addresses the problem of inferring circulation of information between multiple stochastic processes. We discuss two possible frameworks in which the problem can be studied: directed information theory and Granger causality. The main goal of the paper is to study the connection between these two frameworks. In the case of directed information theory, we stress the importance of Kramer's causal conditioning. This type of conditioning is necessary not only in the definition of the directed information but also for handling causal side information. We also show how directed information decomposes into the sum of two measures, the first one related to Schreiber's transfer entropy quantifies the dynamical aspects of causality, whereas the second one, termed instantaneous information exchange, quantifies the instantaneous aspect of causality. After having recalled the definition of Granger causality, we establish its connection with directed information theory. The connection is particularly studied in the Gaussian case, showing that Geweke's measures of Granger causality correspond to the transfer entropy and the instantaneous information exchange. This allows to propose an information theoretic formulation of Granger causality.
A bioluminescent transposon reporter-trap identifies tumor-specific microenvironment-induced promoters in Salmonella for conditional bacterial-based tumor therapy.

UNLABELLED Salmonella specifically localize to malignant tumors in vivo, a trait potentially exploitable as a delivery system for cancer therapeutics. To characterize mechanisms and genetic responses of Salmonella during interaction with living neoplastic cells, we custom-designed a promoterless transposon reporter containing bacterial luciferase. Analysis of a library containing 7,400 independent Salmonella transposon insertion mutants in coculture with melanoma or colon carcinoma cells identified five bacterial genes specifically activated by cancer cells: adiY, yohJ, STM1787, STM1791, and STM1793. Experiments linked acidic pH, a common characteristic of the tumor microenvironment, to a strong, specific, and reversible stimulus for activation of these Salmonella genes in vitro and in vivo. Indeed, a Salmonella reporter strain encoding a luciferase transgene regulated by the STM1787 promoter, which contains a tusp motif, showed tumor-induced bioluminescence in vivo. Furthermore, Salmonella expressing Shiga toxin from the STM1787 promoter provided potent and selective antitumor activity in vitro and in vivo, showing the potential for a conditional bacterial-based tumor-specific therapeutic. SIGNIFICANCE Salmonella, which often encounter acidic environments during classical host infection, may co-opt evolutionarily conserved pathways for tumor colonization in response to the acidic tumor microenvironment. We identified specific promoter sequences that provide a platform for targeted Salmonella-based tumor therapy in vivo.
What are motives of family members who take responsibility in palliative cancer care?

Abstract Background and aim. Some studies show that the family members willingly take great responsibility in palliative care. However, their motives for doing so have not been much explored and the aim of this study is to investigate that further. Method. Twenty family members of patients enrolled in palliative care were interviewed in depth. The interviews were taped, transcribed and analysed using a qualitative, hermeneutic method. Results. Love, attachment and outlook on life were the main reasons for shouldering responsibility. An increased consciousness about precious values deepened relations within the family and resulted in personal growth and constituted strong motivation. The process of responsibility was bi-directional with benefits as well as costs. The assumed responsibility brought with it the need to balance feelings about the impending death including such feelings as grief, fear and resignation with those associated with life. Examples of the latter were efforts to retain any remaining capacities within the dying person's body and mind, to hold onto daily routines and to maintain hope and dignity. An essential part of the responsibility was to preserve meaning and avoid the sense of meaninglessness. Discussion. The results contribute to an understanding of complex desires, feelings and needs and provide staff with knowledge when supporting families.
Cassava root meal as substitute for maize in layers ration

The effect of replacing maize with graded levels of cassava root meal (CRM) as energy source in the diet of laying hens was evaluated during the eight weeks of feeding experiment on performance and cost benefits on layers. Forty-five Nera black laying hens of 24 weeks of age were allocated to five dietary treatments, with nine birds per treatment in a completely randomized design. CRM was used to formulate the diets at 0, 25, 50, 75, and 100%. The result showed that the feed intake of birds in the control group was significantly (p<0.05) different from those fed the CRM diets. The average weight gain of layers receiving up to 50% CRM was similar to the control birds, but significantly different from layers fed 75 and 100% CRM. No mortality was recorded. Egg production per hen per day and average egg weight were significantly different (p<0.05) for birds consuming more than 50% CRM in T4 and T5. Layer feed ration was made cheaper by the replacement of maize with cassava root meal in the diets.
Stance and engagement: a model of interaction in academic discourse

A great deal of research has now established that written texts embody interactions between writers and readers. A range of linguistic features have been identified as contributing to the writer's projection of a stance to the material referenced by the text, and, to a lesser extent, the strategies employed to presuppose the active role of an addressee. As yet, however, there is no overall typology of the resources writers employ to express their positions and connect with readers. Based on an analysis of 240 published research articles from eight disciplines and insider informant interviews, I attempt to address this gap and consolidate much of my earlier work to offer a framework for analysing the linguistic resources of intersubjective positioning. Attending to both stance and engagement, the model provides a comprehensive and integrated way of examining the means by which interaction is achieved in academic argument and how the discoursal preferences of disciplinary communities construct both writers and readers.
Axioms and decidability for type isomorphism in the presence of sums

We consider the problem of characterizing isomorphisms of types, or, equivalently, constructive cardinality of sets, in the simultaneous presence of disjoint unions, Cartesian products, and exponentials. Mostly relying on results about polynomials with exponentiation that have not been used in our context, we derive: that the usual finite axiomatization known as High-School Identities (HSI) is complete for a significant subclass of types; that it is decidable for that subclass when two types are isomorphic; that, for the whole of the set of types, a recursive extension of the axioms of HSI exists that is complete; and that, for the whole of the set of types, the question as to whether two types are isomorphic is decidable when base types are to be interpreted as finite sets. We also point out certain related open problems.
Inactivation of Two Dictyostelium discoideum Genes, DdPIK1 and DdPIK2, Encoding Proteins Related to Mammalian Phosphatidylinositide 3-kinases, Results in Defects in Endocytosis, Lysosome to Postlysosome Transport, and Actin Cytoskeleton Organization

Phosphatidylinositide 3-kinases (PI 3-kinases) have been implicated in controlling cell proliferation, actin cytoskeleton organization, and the regulation of vesicle trafficking between intracellular organelles. There are at least three genes in Dictyostelium discoideum, DdPIK1, DdPIK2, and DdPIK3, encoding proteins most closely related to the mammalian 110-kD PI-3 kinase in amino acid sequence within the kinase domain. A mutant disrupted in DdPIK1 and DdPIK2 (Δddpik1/ddpik2) grows slowly in liquid medium. Using FITC-dextran (FD) as a fluid phase marker, we determined that the mutant strain was impaired in pinocytosis but normal in phagocytosis of beads or bacteria. Microscopic and biochemical approaches indicated that the transport rate of fluid-phase from acidic lysosomes to non-acidic postlysosomal vacuoles was reduced in mutant cells resulting in a reduction in efflux of fluid phase. Mutant cells were also almost completely devoid of large postlysosomal vacuoles as determined by transmission EM. However, Δddpik1/ddpik2 cells functioned normally in the regulation of other membrane traffic. For instance, radiolabel pulse-chase experiments indicated that the transport rates along the secretory pathway and the sorting efficiency of the lysosomal enzyme α-mannosidase were normal in the mutant strain. Furthermore, the contractile vacuole network of membranes (probably connected to the endosomal pathway by membrane traffic) was functionally and morphologically normal in mutant cells. Light microscopy revealed that Δddpik1/ddpik2 cells appeared smaller and more irregularly shaped than wild-type cells; 1–3% of the mutant cells were also connected by a thin cytoplasmic bridge. Scanning EM indicated that the mutant cells contained numerous filopodia projecting laterally and vertically from the cell surface, and fluorescent microscopy indicated that these filopodia were enriched in F-actin which accumulated in a cortical pattern in control cells. Finally, Δddpik1/ddpik2 cells responded and moved more rapidly towards cAMP. Together, these results suggest that Dictyostelium DdPIK1 and DdPIK2 gene products regulate multiple steps in the endosomal pathway, and function in the regulation of cell shape and movement perhaps through changes in actin organization.