Miracle-dz/UniFAR-FTUs huggingface dataset:
A 3nm CMOS FinFlex™ Platform Technology with Enhanced Power Efficiency and Performance for Mobile SoC and High Performance Computing Applications

The industry fastest time-to-manufacturability 3nm CMOS platform technology is presented. FinFlex™ with standard cells consisting of different fin configurations is introduced for the first time to offer the critical design flexibility for better power efficiency and performance optimization compared to traditional FinFET technologies. An aggressive scaling of ~1.6X logic density increase, 18% speed improvement and 34% power reduction are achieved over our previous 5nm CMOS process. This FinFlex™ platform technology provides the best-in-class PPAC values to fully unleash product innovations in 5G and HPC applications.
LATTICE BOLTZMANN SIMULATION OF DEFORMATION AND BREAKUP OF A DROPLET UNDER GRAVITY FORCE USING INTERPARTICLE POTENTIAL MODEL

In this paper interparticle potential model of the lattice Boltzmann method (LBM) is used to simulate the deformation and breakup of a falling droplet under the gravity force. First, this model is applied to ensure that the surface tension effect is properly implemented in this model. Two tests have been considered. First, it has been checked an initial square drop in a 2D domain can freely deform to a circular drop and secondly the coalescence of two static drops that merge to become a single circular drop is simulated. In order to further verify the model, Laplace law for static drops is performed. In the next step, wall effects on the droplet shape and its average velocity have been studied. It is seen that the average velocity of droplet at different times is ind ependent of wall effects when the ratio of the width of the channel to droplet diameter (W/D) is more than 6. In the final section of the paper, deformation and breakup of a falling droplet for some range of Eotvos and Ohnesorge numbers are investigated. It is seen that at very low Eotvos numbers, where the surface tension force is dominant, the droplet deforms slowly and reaches a steady state without breakup. At higher Eotvos numbers gravitational force overcome the surface tension force and the droplet deforms more. For breakup modes at the small Ohnesorge number, if Eotvos number be increased to an intermediate value, the droplet deforms more than from a state of low Eotvos number value and eventually forms a backward-facing bag. Finally, for high Eotvos numbers, fragments of droplet are sheared from the edges and the shear breakup mechanism is seen. On the other hand, the stabilizing effect of the Ohnesorge number, (the ratio of viscous stresses and surface tension) is shown. At higher Ohnesorge number, the simulations show that the main effect of increasing Ohnesorge number is to move the boundary between the different breakup modes to higher Eotvos number.
Note on the iterative method in nuclear problems

1. With the assumption of two-body forces it has been found possible to estimate approximately the binding energies of the simplest atomic nuclei (H, H, He) for a number, of potential functions. The iterative technique developed by Svartholm is eminently suited to this purpose for well-known reasons; in what follows we shall therefore adopt his approach(l). A fairly adequate treatment of the two-, threeand four-body problems is possible with the assumption of Gaussian interactions. Of the other potentials at present in use that due to Yukawa is in many ways the most important, but at the same time its adoption raises great computational difficulties. In this note we shall be concerned with the improvement of the iterative treatment by simple modification of the initial function. Since, however, this first approximation to the wave function is in essence a product function of appropriate symmetry, based on the deuteron function, the most suitable analytical form will be suggested by a preliminary examination of the two-body case.
Combined Micro-Needling with Lyophilized Platelet-Rich Plasma versus Micro-Needling Monotherapy in The Treatment of Atrophic Post-Acne Scars: Split-Face Study

Background: Combined micro-needling with platelet-rich plasma (PRP) is an effective treatment option for atrophic post-acne scars. Lyophilized PRP (L-PRP) is a novel, simpler, standardized preparation of PRP. The combined treatment of post-acne scars with micro-needling and L-PRP hasn’t been previously investigated. Objectives: This study aimed to compare the effectiveness of the combined use of micro-needling and L-PRP versus micro-needling only in treating atrophic post-acne scars. Patients and methods: This randomized controlled split-face study included 20 adult patients with post-acne atrophic scars. One side of the face was treated with micro-needling. The other side was treated with micro-needling and L-PRP. The treatment was applied at 2 weeks intervals for 3 sessions. The assessment was done with Antera 3D ® camera analyzer. The mean indentation index of each side of the face was calculated before and two weeks after the last treatment. Results: Our study showed that the mean age of patients was 28.35 ± 4.87 years, 90% were females, and 20% were males. 50% had Fitzpatrick skin type III, while the other half had skin type IV. Both micro-needling monotherapy and combined micro-needling with L-PRP produced significant improvement in the mean indentation index of atrophic post-acne scars. However, the mean percentage of improvement was higher in the combined treatment group. Side effects were minimal and transient with both treatment modalities. Conclusion: Combined treatment with micro-needling and L-PRP showed superior results in improving atrophic post-acne scars and is regarded as a safe, simple, and cost-effective treatment modality.
The Relationship among Dyadic Adjustment and Disease Burden in Patients with Bipolar Disorder and Their Spouses

(1) Background: Spouses of individuals with bipolar disorder (BD) experience significant burdens, and the perception of the burden may affect dyadic adjustment. We aimed to investigate the sexual functions, alexithymic traits, marital satisfaction, and burden in patients with BD and their spouses. We also aimed to assess the mediating role of sexual functions and alexithymia in the relationship between burden and dyadic adjustment. (2) Methods: We included 81 patients with BD type 1 (40.69 ± 8.55 years, 65.4% female, and 34.6% male) and their healthy spouses (40.95 ± 7.30 years, 34.6% female, and 65.4% male) and 78 healthy controls (38.90 ± 5.88, 48.7% female, and 51.3% male). The participants were evaluated using the Golombok–Rust Inventory of Sexual Satisfaction (GRISS), Dyadic Adjustment Scale (DAS), Hamilton Depression Rating Scale (HDRS), Toronto Alexithymia Scale-20 (TAS-20), and Burden Assessment Scale (BAS). (3) Results: The GRISS scores of the control group were significantly lower than the spouses and BD groups. The DAS total score of the control group was significantly higher than that of the spouses and BD groups. Regression analyses revealed that TAS, GRISS, and HDRS scores were associated with DAS scores in the BD group. In the spouse group, TAS and BAS scores were associated with DAS scores. The GRISS scores partially mediated the relationship between dyadic adjustment and burden in the spouses of patients with BD. (4) Conclusions: Mental health professionals should regularly scan caregivers’ perceptions of burden. Appropriate psychosocial interventions could help spouses of patients with BD to cope better with the burden and improve dyadic adjustment.
Equation of state of bulk metallic glasses studied by an ultrasonic method

The acoustic velocities and their pressure dependence of various Zr- and Pd-based bulk metallic glasses (BMGs) have been measured by using a pulse echo overlap method. The elastic constants as well as their pressure dependence of the BMGs have been determined, and the equation of state of these BMGs was obtained and compared to that of other glasses and crystalline solids. The structural characteristic of the BMGs is discussed.
An R-matrix with pseudo-states approach to the electron-impact excitation of H I for diagnostic applications in fusion plasmas

Electron-impact excitation cross sections for transitions between terms up to the n = 5 shell of neutral hydrogen have been calculated using the R -matrix method with pseudostates and compared with previous studies. Maxwell-averaged effective collision strengths have been prepared and used in population calculations to examine effective emission coefficients for diagnostic applications in fusion plasmas. Our results remove an uncertainty in the reaction rates of an important class of atomic processes governing H I emission in plasmas.
Near-death experiences and the change of worldview in survivors of sudden cardiac arrest: A phenomenological and hermeneutical study

Near-death experiences (NDEs) can occur during episodes of unconsciousness from life-threatening conditions, such as sudden cardiac arrests (SCAs). This study is based on interviews with patients who had an NDE. The interviews were analyzed with phenomenological hermeneutical method for their lived experiences and the meaning for the view of life and death. Four participants were interviewed 10 weeks after their NDE. Four themes emerged: being on the other side, in another dimension; not dreaming, this is a real experience; being in a non-physical condition without my body; and comparing views of life and death before and after the NDEs. The participants described the NDEs as an experience of another realm as non-physical in nature and existing beyond space and time. This study shows that this experience of another state of being, through the lived experiences of NDEs, gave the participants an entirely new meaning on life and death. To them, death was no longer viewed as an end but a passage into something else and that life continues after death. This realization instantly changed their worldview.
Development and Recent Advances in Lysine and N-Terminal Bioconjugation for Peptides and Proteins

The demand for creation of protein diversity and regulation of protein function through native protein modification and post-translational modification has ignited the development of selective chemical modification methods for peptides and proteins. Chemical bioconjugation offers selective functionalization providing bioconjugates with desired properties and functions for diverse applications in chemical biology, medicine, and biomaterials. The amino group existing at the lysine residue and N-terminus of peptides and proteins has been extensively studied in bioconjugation because of its good nucleophilicity and high surface exposure. Herein, we review the development of chemical methods for modification of the amino groups on lysine residue and N-terminus featuring excellent selectivity, mild reaction conditions, short reaction time, high conversion, biocompatibility, and preservation of protein integrity. This review is organized based on the chemoselectivity and site-selectivity of the chemical bioconjugation reagents to the amino acid residues aiming to provide guidance for the selection of appropriate bioconjugation methods.
Earthquake‐induced hydrodynamic pressures on a 3D rigid dam–reservoir system using DRBEM and a radiation matrix

The dual reciprocity method is applied to determine the hydrodynamic pressure distribution in a three‐dimensional dam–reservoir system subjected to earthquake excitation. The reservoir domain is idealized as a finite region of irregular geometry adjacent to the dam followed by an infinite domain of uniform cross‐section in the upstream direction. The reservoir hydrodynamic pressure response is governed by the Helmholtz equation subject to free surface, dam–reservoir interface, absorbing bottom/banks and radiation boundary conditions. A three‐dimensional (3D) dual reciprocity model is developed to determine the hydrodynamic pressure in the finite reservoir domain. A radiation matrix is developed and introduced to relate the hydrodynamic pressure and its normal derivative on the interface between the finite and infinite domains. The three‐dimensional radiation model used is developed by applying a two‐dimensional dual reciprocity formulation along the interface of the finite and infinite reservoirs together with a continuum solution in the upstream direction of the infinite domain. The model is compared for the hydrodynamic response of a three‐dimensional rectangular reservoir and found to be in excellent agreement with results obtained from a model based on the analytical formulation existing in the literature. Copyright © 2003 John Wiley & Sons, Ltd.
Carbonyl Cyanide 3-Chloro Phenyl Hydrazone (CCCP) Restores the Colistin Sensitivity in Brucella intermedia

Brucella intermedia (formerly Ochrobactrum intermedium), a non-fermentative bacterium, has been isolated from animals and human clinical specimens. It is naturally resistant to polymyxins, including colistin (CO), and may cause opportunistic infections in humans. We isolated six Brucella intermedia strains from Senegalese monkey stool. In order to determine whether an efflux pump mechanism was involved in CO resistance in B. intermedia, we evaluated the effects of verapamil (VRP), reserpine (RSP), phe-arg β-naphthylamide dihydrochloride (PAβN) and carbonyl cyanide 3-chloro phenyl hydrazone (CCCP), four efflux pump inhibitors, on these colistin-resistant strains. Using the broth microdilution method, a CO and CCCP combination of 2 µg/mL and 10 µg/mL, respectively, significantly reduced the CO minimal inhibitory concentration (MIC) of B. intermedia, supporting an efflux pump mechanism. In contrast, VRP, PAβN and RSP did not restore CO susceptibility. A time kill assay showed a bactericidal effect of the CO–CCCP combination. Genomic analysis revealed a potential implication in the CO resistance mechanism of some conserved efflux pumps, such as YejABEF, NorM and EmrAB, as previously reported in other bacteria. An inhibitory effect of the CO–CCCP combination was observed on biofilm formation using the crystal violet method. These results suggest that the intrinsic CO resistance in Brucella intermedia is linked to an efflux pump mechanism and that the synergistic effect of CO–CCCP may open a new field to identify new treatments to restore antibiotic efficacy in humans.
`Infinite domain' elements

A parametric element is formulated which enables the economic modelling of ‘infinite domain’ type problmes. A typical problem is an opening in a stress field in an infinite medium, either in two or three dimensions. The strategy is to model around the opening with two or three layers of conventional isoparametric finite elements and surround these with a single layer of ‘infinite domain’ elements. Several sample problems has been analysed for circular, square and spherical openings in infinite media, and the results compared with either theoretical or boundary element solutions which include the ‘infinite’ boundary in their solution technique. Copyright
Association between ADAM33 Single-Nucleotide Polymorphisms and Treatment Response to Inhaled Corticosteroids and a Long-Acting Beta-Agonist in Asthma

ADAM33 has been linked to airway structural changes in patients with asthma, leading to airway hyperresponsiveness, narrowing, and ultimately poor treatment responsiveness. This study aimed to evaluate the genetic association of ADAM33 SNPs with asthma, disease severity, and treatment responsiveness to ICS+LABA in the South Indian population. In this case–control study (486 controls and 503 cases), we performed genotyping using MassArray for six SNPs of ADAM33, namely rs2280091, rs2787094, rs3918396, rs67044, rs2853209, and rs3918392. We studied the association with asthma and treatment responsiveness to ICS+LABA, using genotype, allele frequency distribution, and haplotype analysis. A significant clinical finding of the study was that certain patients in the disease severity group (moderate and mild) showed poor or no improvement after a three-month follow-up of regular ICS+LABA therapy. Of the studied ADAM33 SNPs, rs2853209 showed an association with asthma. The further analysis of asthma patients according to disease severity suggested an association between moderate disease and the minor allele “T” for rs2853209. The homozygous minor allele of SNP rs2787094 was found to be associated with poorer lung function and the least lung-function improvement after three months of ICS+LABA therapy. The haplotype analysis of six SNPs showed a significant association between the rs2853209 and rs3918396 blocks and asthma. ADAM33 gene polymorphism has clinical relevance in terms of disease association and response to treatment. SNP rs2853209 seemed most relevant to asthma, and SNP rs2787094 could be a genetic marker for predicting response to ICS+LABA therapy in the study population.
App2Net: Moving Application Functions to Network & a Case Study on Low-latency Feedback

Recent advances in programmable networks enable custom processing of data at hundreds of gigabits per second. These advances can boost the performance of many distributed applications. Yet the high-level languages used by application developers are different from the data plane programming languages (such as P4 and NPL) used by network equipment. This language barrier slows innovation. Our hourglass-shaped architectural solution aims to lower this language barrier. This enables the application developer community to leverage programmable networks for achieving better performance. In this paper we propose a JSON-based intermediate representation to bridge the gap between applications and in-network computing. We demonstrate an instance of the solution in the context of a low-latency feedback application that enables SQL-based data filtering in a P4-based programmable environment. We also present a prototype compiler to convert an intermediate representation in JSON to P4 source.
Last-Mile Drone Delivery: Past, Present, and Future

Sustainable green products and services garner more attention from companies and enterprises that aim to succeed and grow in highly competitive markets by imposing less harms on the environment and ecosystems. Last-mile delivery from local distribution centers to customers plays an essential role in the retail business. Retail companies are leaning towards implementing green, efficient transportation methods, such as drones, in their last-mile delivery operations for reasons of ecological conservation. Accordingly, researchers have documented numerous research findings on last-mile drone delivery in recent years. This literature review selected a collection of articles mostly from 2011 to 2022 and reviewed them in terms of key technical challenges, such as routing, cargo distribution optimization, battery management, data communication, and environmental protection. These challenges are interrelated in a sense of achieving eco-friendly, efficient, lean, last-mile drone delivery. The selection of these technical challenges is based on the top challenges discussed in the literature.
Time‐domain first‐Born approximations to backscattering from cylinders

Time‐domain first‐Born approximations to backscattering of observed incident elastodynamic pulses by isolated cylindrical voids or inclusions are produced with rapid and computationally inexpensive procedures using polynomial splines represented as a series of basic splines. The approximations are in good qualitative agreement, and fair quantitative agreement, with observed backscatter.
Superior Breakdown, Retention, and TDDB Lifetime for Ferroelectric Engineered Charge Trap Gate E-mode GaN MIS-HEMT

A ferroelectric engineered charge trap gate E-mode GaN MIS-HEMT (FEG-HEMT), La-doped $\mathbf{H f}_{0.5} \text{Zr}_{0.5} \mathbf{O}_{2}$ (HZLO) with seed layer (SL), significantly reduced thermal budget $\left(\sim 200^{\circ} \text{C}\right)$, lowered leakage current, and 50% increase in $2P_{\text{r}}$, is implemented for the first time. The high-performance E-mode FEG-HEMT exhibits a positive $V_{\text {th}}$ of 3.7 V while maintaining a ID, max of 560 mA/mm, a high off-state breakdown voltage of 917 V, and proved excellent $V_{\text {th}}$ stability with an estimated $V_{\text {th}}$ of 2.9 V after 10 years of retention. High gate breakdown of $V_{\text{GS}}=\mathbf{26.6} \text{V}$ and long time-dependent gate dielectric breakdown (TDDB) (13.38 V at a failure rate of 0.01%) is achieved.
Comparison of two-dimensional phase retrieval methods from single interference fringe pattern

Accurate phase retrieval from single fringe pattern is significant for dynamic phase measurement. Although it brings issues of speckle noise and severe non-sinusoidal waveform, the interference fringe pattern by coherent light is still often used for profile measurement, especially for measuring target with low reflective surface. Both simulation and experiment are carried out to study performance of two-dimensional Fourier transform, windowed Fourier transform(including windowed Fourier filtering and windowed Fourier ridges), and wavelet transform methods. The influence of the speckle noise and non-sinusoidal waveform to those phase retrieval methods is compared and discussed.
Microstrip Rejecting Bandstop Filter

The paper is devoted to simulation, designing and fabrication of a microstrip 5-order bandstop rejecting filter. The bandstop filter uses classic schem, e.g. it consists of a microstrip through (common) line whose ends serve input and output ports. In the vicinity of the line a number of microstrip rejecting resonators locate, in our case five S-shaped resonators. They electromagnetically interact with the line, that forces signals, having frequenscies, bieng equal to the resonant ones, to reject (reflect) from a device. Dielectric substrate of the device has thickness 1.0 mm, and other sizes are 44.0×20.0 mm2. The filter described in this work has shielding. In a band 1480 MHz …1499 MHz rejection exceeds 50 dB. Transmission bands at a level –2 dB are 0…1437 MHz and 1563 MHz…3000 MHz lower and upper correspondingly. Return loss in the passbands does not exceed –16 dB (VSWR≤1.4). Good agreement is observed between simulated and experimental data. Fabricated filter has small size.
Role of the Endocannabinoid System in Metabolic Control Processes and in the Pathogenesis of Metabolic Syndrome: An Update

Metabolic syndrome is a complex disease state, which appears mostly as a consequence of an unhealthy, sedentary lifestyle. Metabolic complications include insulin resistance (IR), diabetes, dyslipidemia, hypertension, and atherosclerosis, impairing life standards and reducing life expectancy. The endocannabinoid system (ECS) has an important role in signalization processes, not only in the central nervous system, but also in the peripheral tissues. Several physiological functions are affected, and overexpression or downregulation contributes to several diseases. A better understanding of the functions of cannabinoid (CB) receptors may propose potential therapeutic effects by influencing receptor signaling and enzymes involved in downstream pathways. In this review, we summarize recent information regarding the roles of the ECS and the CB1 receptor signaling in the physiology and pathophysiology of energy and metabolic homeostasis, in the development of obesity by enhancing food intake, upregulating energy balance and fat accumulation, increasing lipogenesis and glucose production, and impairing insulin sensitivity and secretion. By analyzing the roles of the ECS in physiological and pathophysiological mechanisms, we introduce some recently identified signaling pathways in the mechanism of the pathogenesis of metabolic syndrome. Our review emphasizes that the presence of such recently identified ECS signaling steps raises new therapeutic potential in the treatment of complex metabolic diseases such as diabetes, insulin resistance, obesity, and hypertension.