Miracle-dz/UniFAR-FTUs huggingface dataset:
Osteoblast–Seeded Bioglass/Gelatin Nanocomposite: A Promising Bone Substitute in Critical-Size Calvarial Defect Repair in Rat

Introduction Amid the plethora of methods to repair critical bone defects, there is no one perfect approach. In this study, we sought to evaluate a potent 3-dimensional (3D) bioactive SiO2-CaO-P2O5 glasses (bioglass)/gelatin (gel) scaffold for its biocompatibility by seeding cells as well as for its regenerative properties by animal implantation. Methods Osteoblast cells were seeded onto nanocomposite scaffolds to investigate the process of critical-size calvarial defect via new bone formation. Scanning electron microscopy (SEM) was used to validate topography of the scaffolds, its homogeneity and ideal cellular attachment. Proliferation assay and confocal microscopy were used to evaluate its biocompatibility. To validate osteogenesis of the bioactive nanocomposite scaffolds, they were first implanted into rats and later removed and analyzed at different time points post mortem using histological, immunohistochemical and histomorphometric methods. Results Based on in vitro results, we showed that our nanocomposite is highly cell-compatible material and allows for osteoblasts to adhere, spread and proliferate. In vivo results indicate that our nanocomposite provides a significant contribution to bone regeneration and is highly biodegradable and biocompatible. So, seeded scaffolds with osteoblasts enhanced repair of critical bone defects via osteogenesis. Conclusions We demonstrate the feasibility of engineering a nanocomposite scaffold with an architecture resembling the human bone, and provide proof-of-concept validation for our scaffold using a rat animal model.
Acume: A new visualization tool for understanding facial expression and gesture data

Facial and head actions contain significant affective information. To date, these actions have mostly been studied in isolation because the space of naturalistic combinations is vast. Interactive visualization tools could enable new explorations of dynamically changing combinations of actions as people interact with natural stimuli. This paper describes a new open-source tool that enables navigation of and interaction with dynamic face and gesture data across large groups of people, making it easy to see when multiple facial actions co-occur, and how these patterns compare and cluster across groups of participants. We share two case studies that demonstrate how the tool allows researchers to quickly view an entire corpus of data for single or multiple participants, stimuli and actions. Acume yielded patterns of actions across participants and across stimuli, and helped give insight into how our automated facial analysis methods could be better designed. The results of these case studies are used to demonstrate the efficacy of the tool. The open-source code is designed to directly address the needs of the face and gesture research community, while also being extensible and flexible for accommodating other kinds of behavioral data. Source code, application and documentation are available at http://affect.media. mit.edu/acume.
Quantitative Assessment of the Log-Log-Step Method for Pattern Detection in Noise-Prone Environments

Staircase-like structures in the log-log correlation plot of a time series indicate patterns against a noisy background, even under condition of strong jitter. We analyze the method for different jitter-noise-combinations, using quantitative criteria to measure the achievement by the method. A phase diagram shows the remarkable potential of this method even under very unfavorable conditions of noise and jitter. Moreover, we provide a novel and compact analytical derivation of the upper and lower bounds on the number of steps observable in the ideal noiseless case, as a function of pattern length and embedding dimension. The quantitative measure developed combined with the ideal bounds can serve as guiding lines for determining potential periodicity in noisy data.
SDN-based traffic engineering for improved resilience in integrated satellite-terrestrial backhaul networks

Resilience and high availability are considered as essential requirements in 5G networks. To fullfil these requirements, the integration of a satellite component within mobile backhaul networks arises as a compelling proposition to provide backup connectivity to critical cell sites and divert traffic from congested areas so that a limited capacity in their terrestrial links could be supplemented during peak-time or even replaced in case of total/partial failure or maintenance. This is especially of interest for public protection and disaster relief (PPDR) communications in remote/rural areas that might require the fast deployment of nework capacity as well as in distressed areas where the terrestrial backhaul infrastructure might have suffered damages. This paper first describes an architectural framework that enables the integration and management of the satellite capacity as a constituent part of a Software Defined Networking (SDN)-based traffic engineered mobile backhaul network. Then, a SDN-based Traffic Engineering (TE) application is proposed to manage some amount of dynamically steerable satellite capacity provisioned for resilience purposes to maximize a network utility function under both failure and non-failure conditions in the terrestrial links. Numerical results are presented to assess the benefits of the proposed TE application and its performance is compared to that of a traditional overflow solution.
Advanced monitoring of the OpenStack NFV infrastructure: A Nagios approach using SNMP

This paper is focused on evaluation of Nagios, an open-source flexible monitoring tool for enterprises, in a cloud-based network orchestrated by OpenStack. The work relies on a previous work done within UC Labs which added new objects (i.e. QoS parameters) in a management information base MIB. The solution aims at collecting the Available Transfer Rates and One-Way Delays of the links within the cloud, in order to provide the optimization of the Network Virtualization Functions.
WebPro: A proxy-based approach for low latency web browsing on mobile devices

To load a webpage, a web browser first downloads the base HTML file of the page in order to discover the list of objects referenced in the page. This process takes roughly one round-trip time and constitutes a significant portion of the web browsing delay on mobile devices as wireless networks suffer from longer transmission and access delays compared to wired networks. In this work, we propose a solution for eliminating this initial delay, which is transparent to end systems, does not require modifying HTTP, and is well suited for web browsing on mobile devices. Our solution, called WebPro, relies on a network proxy that builds an up-to-date database of resource lists for the websites visited frequently by network users. The proxy resides in the wired part of the network, and hence can afford to pro-actively build and refresh the resource list database periodically. When a request for a webpage comes to the proxy, it simultaneously fetches the base HTML and all referenced objects required to render the webpage using the corresponding resource list stored in the local database. We have built a working prototype of WebPro and have conducted live experiments over WiFi and LTE networks. Our results show an average of 26% reduction in page load time for a mix of popular web sites chosen from categories such as news, sports and shopping. Moreover, in comparison to another best known proxy-based solution, WebPro provides delay reductions ranging from 5% to 51% for a variety of web sites.
Injury Prevention Exercise Programs for Professional Soccer: Understanding the Perceptions of the End-Users

Objective: To evaluate the perceptions of professional soccer players and staff members toward injury prevention exercise programs (IPEPs). Design: Self-report survey. Setting: Four professional soccer teams in 4 different countries. Participants: 126 players, coaches, physiotherapists, and fitness coaches were invited to participate, with 72 respondents. Main Outcome Measures: Web-based survey detailing perceptions of lower limb (LL) injury susceptibility and seriousness, the value of IPEPs in general, and more specifically the International Federation of Association Football (FIFA) 11+. Results: The vast majority of the respondents believed that professional soccer players are at high risk of LL injuries (93%) and that players should perform evidence-based injury prevention exercises (98%). They also agreed that LL injuries can shorten a player's career (85%), cause physical problems later in life (82%), and negatively impact on team performance (77%). However, perceptions varied across teams regarding which types of injury prevention exercises are effective, who holds responsibility for injury prevention, and when IPEPs should be performed. Specific knowledge of the FIFA 11+ was very low and 47% of respondents believed the program would need modification for use in their team. Conclusions: Players and staff members in professional soccer teams strongly support the use of evidence-based IPEPs. However, perceptions vary considerably between teams regarding which exercises can prevent injuries, who holds the responsibility for injury prevention, and when preventive exercises should be performed. Enhancing the ultimate impact of IPEPs in professional soccer requires a detailed understanding of each team's specific implementation context.
Surface extensions on BHK cells grown in monolayers and agar supension.

Three types of surface extensions found on a subline of BHK cells capable of growing in agar are described. These are: 1. Microvilli-borne on the cell surface, lacking rigid cores, found on trypsinized cells and on cells growing in solid tissue type growth; 2. Microspikes-borne on the cell margins, containing rigid cores, found on spread, attached cells, but not trypsinized cells or cells growing in solid tissues; 3. Retraction fibrils-coreless ‘passive’ cell extensions drawn out distally as motile cells move across a surface. Microvilli also seem to be associated with micropinocytic vesicles. It is suggested that microvilli on tissue cells in vitro may be homologous with the cell membrane interdigitations found in, for example, gut epithelium, and possibly also with the microvilli of brush borders. Their association with these structures suggests they may play a role in producing a local environment near the cell membrane in which micropinocytosis may function more effectively.
Wireless Sensor Network Softwarization: Towards WSN Adaptive QoS

Connecting wireless sensor networks (WSNs) to remote servers or clouds through the Internet of Things inspires the formation of a highly complex system. This has significant potential to encourage WSN softwarization. Such a network enables interaction between the physical and virtual sensor network, allowing for flexibility within the physical system to adapt with the dynamics of the service requirements. An architecture of a test environment with adaptive quality of service (AQoS) has been presented. The concept provides an avenue for a flexible system that is capable of reacting to dynamic changes of process demands. Physical network performance can be predicted by analyzing the historical data in the background on a network simulator or virtual network. This in turn allows for estimation of the necessary adjustments needed to improve the network performance without disturbing the physical system. This paper reports the experimentation and applicability of user-driven AQoS models on the system. Early stages of testing the organization, taking into account the system behavior and subsequent reaction to necessary adjustment of the WSN operational configuration, has shown encouraging results.
Advances in immunotherapy of hematologic malignancies

&NA; The chimeric anti-CD20 antibody rituxamab, as well as radiolabeled anti-CD20 monoclonal antibodies, have demonstrated significant activity against B-cell non-Hodgkin's lymphoma. Idiotype vaccination in remission may prevent relapse in follicular non-Hodgkin's lymphoma. The campath-1H antibody has activity in chronic lymphocytic leukemia, and additional unconjugated, radiolabeled, and drug-conjugated monoclonal antibodies (anti-CD45 and anti-CD33) have shown activity in acute myeloid leukemia. Adoptive cellular therapy is active against posttransplantation relapse and lymphoproliferative disorders in most patients, and complications of graft-versushost disease may be controlled by suicide gene transfection of the donor lymphocytes.
(Re)conceptualizing resistance to (re)conceptualize campus climate challenges: Analyzing the resistant register of student reflection writing in a university diversity course

v CHAPTER ONE: INTRODUCTION 1 CHAPTER TWO: REVIEWING THE LITERATURE 16 CHAPTER THREE: CONCEPTUALIZING THE RESEARCH 35 CHAPTER FOUR: CONDUCTING THE RESEARCH 59 CHAPTER FIVE: DISCOVERING THE REGISTER OF RESISTANCE 74 CHAPTER SIX: IMPLICATIONS AND CONCLUSIONS 111
Trauma and Recovery: The Aftermath of Violence — from Domestic Abuse to Political Terror

Trauma and Recovery: The Aftermath of Violence — from Domestic Abuse to Political Terror, Judith Lewis Herman. New York: Basic Books, 1992. 276 pp. $27.00. ISBN 0-465-08765–5. Shattered Assumptions: Toward A New Psychology of Trauma, Ronnie Janoff-Bulman. New York: The Free Press, 1992, 256 pp. $24.95. ISBN 0-02-916015–4.
No-Hole L � p 0 Labelings †

We address here a particular case of the general problem of λ labelings, motivated by frequency assignment for telecommunication networks. In this model, stations lying within a given radius r must use frequencies that differ at least by a value p, while stations that are within a larger radius r must use frequencies that differ by at least another value q. The aim is to minimize the span of frequencies used in the network. This problem can be modeled by a graph labeling problem, called the L p q labeling, where one wants to label nodes of a graph G modeling the network by integers in the range 0;M , while minimizing the value of M. M is then called the λ number of G, and is denoted by λ q G . A variant of this problem is when all the possible frequencies (i.e., all the possible values in the span) must be used. In this paper, we focus on this problem. More precisely, the constraints are that: (1) all the frequencies are used and (2) condition (1) being satisfied, the span must be minimum. This problem is usually called the no-hole L p q labeling problem. Let 0;M be this new span (thus, clearly, M M). We then call the ν number of G the value M , and we denote it by ν q G . Hence, we have ν q G λ q G for any p,d and G (a no-hole L p q labeling being an L p q labeling). We study here a special case of no-hole L p q labeling, where q 0. We first give some general results, before focusing on some specific topologies, namely: cycles, d-dimensional hypercubes, 2-dimensional and 3-dimensional grids. For each of those topologies, we give bounds on the ν 0 number for any value of p 1, and show optimality in some cases.
Chronic Hypoxia Suppresses Pregnancy-Induced Upregulation of Large-Conductance Ca2+-Activated K+ Channel Activity in Uterine Arteries

Our previous study demonstrated that increased Ca2+-activated K+ (BKCa) channel activity played a key role in the normal adaptation of reduced myogenic tone of uterine arteries in pregnancy. The present study tested the hypothesis that chronic hypoxia during gestation inhibits pregnancy-induced upregulation of BKCa channel function in uterine arteries. Resistance-sized uterine arteries were isolated from nonpregnant and near-term pregnant sheep maintained at sea level (≈300 m) or exposed to high-altitude (3801 m) hypoxia for 110 days. Hypoxia during gestation significantly inhibited pregnancy-induced upregulation of BKCa channel activity and suppressed BKCa channel current density in pregnant uterine arteries. This was mediated by a selective downregulation of BKCa channel &bgr;1 subunit in the uterine arteries. In accordance, hypoxia abrogated the role of the BKCa channel in regulating pressure-induced myogenic tone of uterine arteries that was significantly elevated in pregnant animals acclimatized to chronic hypoxia. In addition, hypoxia abolished the steroid hormone-mediated increase in the &bgr;1 subunit and BKCa channel current density observed in nonpregnant uterine arteries. Although the activation of protein kinase C inhibited BKCa channel current density in pregnant uterine arteries of normoxic sheep, this effect was ablated in the hypoxic animals. The results demonstrate that selectively targeting BKCa channel &bgr;1 subunit plays a critical role in the maladaption of uteroplacental circulation caused by chronic hypoxia, which contributes to the increased incidence of preeclampsia and fetal intrauterine growth restriction associated with gestational hypoxia.
NURSES' ROLE IN PREVENTION OF INFANT AND UNDER-FIVE CHILD MORTALITY IN AFRICA : A literature review

The under-five mortality rate remains unacceptably high with 6.3 million children dying before their fifth birthday in 2013. Research has, however, revealed that nurses are the means to reducing these untimely deaths. The aim of this research is to examine and identify the role nurses play in preventing and reducing infant and under-five mortality. The purpose of the study was to provide research based information of the position of nurses in consideration to childhood deaths. Data for the research were obtained from PubMed and ScienceDirect search engines as well as manual data search. The accepted studies were published between the years 2000 and 2015. In total nine studies were analyzed. Inductive content analysis was the chosen method of data analysis. The results of the study indicate there are challenge nurses face while trying to reduce and or prevent these early deaths. Nurses are challenged with inadequate medical care facilities, high maternal mortality rate as well as lack of training. Other challenges were also noted. The results also shows the role nurses are currently taking as well as some other roles nurses are suggested to play in order to lessen under-five mortality. The findings of this study can be used by health care professionals especially nurses in developing countries. Research on the solutions needed to overcome the challenges faced as well as a study that focuses entirely on the nurses' position is needed. Keywords/tags (16TUsubjectsU16T) Infant mortality, child mortality, child death, nurses' role Miscellaneous
Indirect adaptive fuzzy control for flexible-joint robot manipulators using voltage control strategy

A robot manipulator including its actuators is a complex system due to the nonlinearity, uncertainty and joint flexibility. To overcome complexity, this paper develops a novel indirect adaptive fuzzy control for electrically driven flexible-joint robot manipulators in which a novel estimation technique is introduced to estimate the uncertainty. The control structure differs from the previous ones due to using the voltage control strategy instead of the torque control strategy. The control design has only one control loop whereas the commonly used control design employs two control loops. Moreover, it is a decentralized control whereas the torque-based control design is a centralized control. The required feedbacks for each controller are the motor current, joint position, joint velocity and motor velocity. Some advantages are: considering the whole robotic system including robot and its actuators as a fifth-order model, simplicity of control design, computational efficiency, good performance, and guaranteed stability. Simulation results and comparisons show the effectiveness and superiority of the control approach over two control approaches. The first approach is a modified fuzzy proportional-integral control as a torque-based control method and the second one is a robust control as a voltage-based control method.
A Direct Interaction Approach to Identify Real Options "In" Large-Scale Infrastructure Systems

There is a universe of real options opportunities for infrastructure development that are not fully considered in real options analysis literature. These are known as real options “in” infrastructures systems. They are design components embedded early on “in” the system design process ‐ i.e. prior to fielding and operations ‐ to enable time-to-build, scale alteration, product switching, and many other real options difficult to classify through a discrete set of categories suggested by Trigeorgis (1996). Real options “in” system require technical and engineering knowledge. This differs from real options “on” system focusing on managerial flexibility (e.g. investment deferral, abandonment, growth). Several example case studies show real options “in” system offer significant economic value improvement compared to a baseline inflexible design, ranging between 20% and 80%. Because real options “in” systems are numerous and different from one infrastructure to another, there is a need for analytical tools to guide the engineering effort for valuable opportunities. This paper illustrates some of the research issues involved in developing this field productively. It suggests a potential approach based on direct interactions, discussions, and close work with designers to enable real option opportunities “in” infrastructure systems.
PSYCHIATRIC GENETICS AND THE FUTURE OF PERSONALIZED TREATMENT

Well before the sequencing of the human genome in 2003, family and twin studies had established that psychiatric disorders are both familial and heritable. But identifying the genes involved has been a formidable challenge. At the same time, there has been an urgent need to unlock the biological basis of psychiatric disorders. While psychotropic drugs are helpful for many and life-saving for some, there is a striking fact about available drug therapies: they are all based on serendipitous discoveries and biological insights that date to the 1950s and 1960s. When it comes to treating psychiatric disorders, we are still living in the “Mad Men” era. Lithium has been the gold standard treatment for bipolar disorder ever since John Cade reported its mood stabilizing effects in 1949. All current antipsychotic medications target the D2 dopamine receptor, just as the first medicines in this class did in the 1950s. Antidepressants have relied on variations of the monoamine hypothesis that was articulated in the mid-1960s. The shortcomings of available psychotropics are well-known. The results of large-scale effectiveness studies of mood and psychotic disorders (STAR*D, CATIE, and STEP-BD) are sobering: roughly 30% of depressed patients treated for 14 weeks with an SSRI achieved remission [1];25% of patients with schizophrenia remained on their initial medication by 18 months [2]; and 50% of bipolar patients who achieved recovery from a mood episode relapsed within two years despite best-practice treatment. [3] A major hope hanging on genetic studies has been that they can break this therapeutic impasse, There are three main avenues by which genetic research may inform efforts towards personalized medicine. First, by identifying DNA variants associated with risk of disease, genetic studies may point us toward new treatment targets. The discovery that a specific gene or set of genes confers risk for illness raises the possibility that drugs that target that gene (or genes) may have therapeutic effects. Second, genetic studies may clarify diagnostic boundaries in ways that could inform treatment selection or identify etiologically-related subgroups that might preferentially benefit from a given treatment. And third, pharmacogenetic studies may yield genetic profiles that predict response to available treatments. The following sections address each of these avenues and the state of the science to date.