Miracle-dz/UniFAR-FTUs huggingface dataset:
Adenoviremia has limited clinical impact in the majority of patients following alemtuzumab-based allogeneic stem cell transplantation in adults.

BACKGROUND Adenovirus infection is a potentially serious complication of allogeneic hematopoietic stem cell transplantation (HSCT) and has been reported to occur more frequently following T-cell-depleted reduced-intensity HSCT. However, the true incidence and clinical significance as well as the relationship of disease to viremic titer remain unclear due to wide variation in study populations and methodology. METHODS We performed weekly surveillance blood testing by quantitative polymerase chain reaction on all adult recipients of alemtuzumab-based reduced-intensity HSCT at our institution between January 2008 and January 2011. We collated this with clinical data on treatment and outcomes of adenovirus infection. RESULTS Of 116 HSCT patients analyzed, 14 (12.1%) had adenoviremia with a titer >200 copies/mL. Median time to first detectable titer was 28 days post-HSCT (range, 10-347), and median time to maximum titer was 49 days (range, 16-368). Underlying disease diagnosis (lymphoid > myeloid) and recipient cytomegalovirus (CMV) serostatus (positive > negative) were significantly correlated with adenoviremia. Only 5 patients (with high peak titers of 99 000-2 500 000 copies/mL) received cidofovir; 1 died from complications relating to adenovirus and concurrent CMV infection. CONCLUSIONS We detected adenoviremia at quantifiable levels in only 12.1% of HSCT patients. Attributable mortality was low (0.9% of the entire cohort, 7% of those with adenoviremia) because even infections associated with high viral titers responded to reduction in immunosuppression and treatment with cidofovir in the majority. The clinical significance of adenoviral infection in patients receiving alemtuzumab-based HSCT appears to be less than that previously reported, and only rarely does infection lead to significant morbidity and mortality.
Development, Characterization and Experimental Validation of a Cultivated Sunflower (Helianthus annuus L.) Gene Expression Oligonucleotide Microarray

Oligonucleotide-based microarrays with accurate gene coverage represent a key strategy for transcriptional studies in orphan species such as sunflower, H. annuus L. , which lacks full genome sequences. The goal of this study was the development and functional annotation of a comprehensive sunflower unigene collection and the design and validation of a custom sunflower oligonucleotide-based microarray. A large scale EST (>130,000 ESTs) curation, assembly and sequence annotation was performed using Blast2GO (www.blast2go.de). The EST assembly comprises 41,013 putative transcripts (12,924 contigs and 28,089 singletons). The resulting Sunflower Unigen Resource (SUR version 1.0) was used to design an oligonucleotide-based Agilent microarray for cultivated sunflower. This microarray includes a total of 42,326 features: 1,417 Agilent controls, 74 control probes for sunflower replicated 10 times (740 controls) and 40,169 different non-control probes. Microarray performance was validated using a model experiment examining the induction of senescence by water deficit. Pre-processing and differential expression analysis of Agilent microarrays was performed using the Bioconductor limma package. The analyses based on p-values calculated by eBayes (p<0.01) allowed the detection of 558 differentially expressed genes between water stress and control conditions; from these, ten genes were further validated by qPCR. Over-represented ontologies were identified using FatiScan in the Babelomics suite. This work generated a curated and trustable sunflower unigene collection, and a custom, validated sunflower oligonucleotide-based microarray using Agilent technology. Both the curated unigene collection and the validated oligonucleotide microarray provide key resources for sunflower genome analysis, transcriptional studies, and molecular breeding for crop improvement.
A 21 mW 2.5 Gb/s 15 k/spl Omega/ self-compensated differential transimpedance amplifier

A differential transimpedance amplifier combined with a positive feedback compensation circuit tolerates 1.5 pF parasitic capacitance from ESD protection in 0.35 /spl mu/m SiGe BiCMOS. A 2.5 Gb/s optical receiver demonstrates 15 k/spl Omega/ transimpedance gain and DR from -3 to -23.5 dBm while consuming 21 mW from a 3 V supply.
Confidence and Perceived Competence of Preservice Teachers to Implement Biodiversity Education in Primary Schools—Four comparative case studies from Europe

This multinational research study was carried out between 2004 and 2006 in four teacher education institutions in Cyprus, England, Switzerland, and Germany. With the help of a written questionnaire, the confidence and perceived competence of preservice primary teachers (N = 690) to deliver biodiversity education in school were investigated. Data were triangulated with findings from a previous stage of the overall research project. Study participants' confidence to carry out certain outdoor activities in school increased with the number of similar experiences they had during their own secondary school education, and the more personal classroom experiences they had during their teacher education. A sound knowledge of local wild organisms strongly added to their confidence. However, preservice teachers' perceived competence, and thus motivation to implement biodiversity education later on in school, was related even more strongly to the extent of preparation they had received during their teacher education. The results indicate that teacher education programmes that focus exclusively on filling (biodiversity) knowledge gaps might fail to raise confidence and competence in their students to carry out biodiversity education in school. Programmes that have a higher possibility of attaining effectiveness in biodiversity education seek to strike a balance between background knowledge development, pedagogical content knowledge, and opportunities during teaching practice that leads to experiential gains in enacting meaningful activity sequences and engaging students in holistic educational innovations. Within such programmes, it would be fruitful to further explore the relationship between confidence, perceived competence, and actual teaching performance.
Dissipative transport in nanoscale monolayer MoS2 transistors

Performances of monolayer MoS2 transistors with phonon scattering are investigated. The on-current of a 20nm long device can be degraded by 40% with phonon scattering compared with the ballistic limit. The sub-threshold swing (SS) and drain induced barrier lowering (DIBL) are found to be insensitive to phonon scattering. SS <; 100mV/decade can be achieved with a gate length LG > 5nm and DIBL <; 100mV/V can be achieved with a LG > 8nm for a double gate structure with a 3nm thick high-k gate insulator. Treatment of phonon scattering is important for accurate assessment of intrinsic delay and on/off ratio even at LG ~ 10nm.
Towards a Maritime Domain Extension to Coalition Battle Management Language : Initial Findings and Way Forward

This paper describes initial findings of a multi-national research effort within the NATO Modeling and Simulation Group Technical Activity 085 (MSG-085) Standardization for C2-Simulation Interoperation, to investigate the use of Coalition Battle Management Language (C-BML) in the maritime domain. The purpose of the effort is to de velop a maritime extension to C-BML that will be used for expressing and exchanging plans, orders and reports specific to the maritime domain. The current research and experimentation described in this paper cover the exchange of selected parts of two naval operational messages: Operational General Matters (OPGEN) and Operational Tasking of Anti-Surface Warfare (OPTASK ASUW). A set of information exchange requirements has been developed based on an operational scenario including a Naval Coalition Task Force (CTF) conducting naval operations. Initial findings and lessons learned presented in this paper will be used to create a more comprehensive maritime C-BML extension to be tested during the final experimentation event of MSG-085.
On Interprocess Communication on Interprocess Communication Publication History Capsule Review by Andrei Broder Capsule Review by Paul Mcjones

DEC's business and technology objectives require a strong research program. The Systems Research Center (SRC) and three other research laboratories are committed to lling that need. SRC began recruiting its rst research scientists in l984|their charter, to advance the state of knowledge in all aspects of computer systems research. Our current work includes exploring high-performance personal computing, distributed computing, programming environments, system modelling techniques , speciication technology, and tightly-coupled multiprocessors. Our approach to both hardware and software research is to create and use real systems so that we can investigate their properties fully. Complex systems cannot be evaluated solely in the abstract. Based on this belief, our strategy is to demonstrate the technical and practical feasibility of our ideas by building prototypes and using them as daily tools. The experience we gain is useful in the short term in enabling us to reene our designs, and invaluable in the long term in helping us to advance the state of knowledge about those systems. Most of the major advances in information systems have come through this strategy, including time-sharing, the ArpaNet, and distributed personal computing. SRC also performs work of a more mathematical avor which complements our systems research. Some of this work is in established elds of theoretical computer science, such as the analysis of algorithms, computational geometry , and logics of programming. The rest of this work explores new ground motivated by problems that arise in our systems research. DEC has a strong commitment to communicating the results and experience gained through pursuing these activities. The Company values the improved understanding that comes with exposing and testing our ideas within the research community. SRC will therefore report results in conferences, in professional journals, and in our research report series. We will seek users for our prototype systems among those with whom we have common research interests, and we will encourage collaboration with university researchers. The two parts of this report will appear as separate articles in Distributed Computing. A formalism, not based upon atomic actions, for specifying and reasoning about concurrent systems is deened. It is used to specify several classes of interprocess communication mechanisms and to prove the correctness of algorithms for implementing them. Concurrent systems are customarily described hierarchically, each level being intended to implement the level above it. On each level certain actions are considered atomic with respect to that level, although they decompose into a …
The Influence of Context and Political Identification on Israeli Jews' Views of Palestinians

This study followed changes among Israeli Jews in stereotypic perceptions, attitudes, and feelings toward Palestinians, as a function of political identification on the dove-hawk dimension. The study used the research paradigm of Gilbert (1951) and Karlins, Coffman, and Walters (1969), by administering the same questionnaire to compatible groups of students at 4 points in time between 1990 and 2000, a period in which critical events concerning Palestinian–Israeli relations occurred. Participants were 394 Israeli students enrolled at the School of Education at Tel Aviv University. The analyses showed that dovish participants tended to be more positive toward Palestinian people than the hawkish participants. Also, there was a general tendency for more positive perceptions and attitudes to develop over time. Finally, whereas dovish participants tended to exhibit a linear trend in becoming more positive toward the Palestinians over time, hawkish participants demonstrated a quadratic pattern, with 1995 and 200.
Multimodal retinal image registration using a fast principal component analysis hybrid-based similarity measure

Multimodal retinal images (RI) are extensively used for analysing various eye diseases and conditions such as myopia and diabetic retinopathy. The incorporation of either two or more RI modalities provides complementary structure information in the presence of non-uniform illumination and low-contrast homogeneous regions. It also presents significant challenges for retinal image registration (RIR). This paper investigates how the Expectation Maximization for Principal Component Analysis with Mutual Information (EMPCA-MI) algorithm can effectively achieve multimodal RIR. This iterative hybrid-based similarity measure combines spatial features with mutual information to provide enhanced registration without recourse to either segmentation or feature extraction. Experimental results for clinical multimodal RI datasets comprising colour fundus and scanning laser ophthalmoscope images confirm EMPCA-MI is able to consistently afford superior numerical and qualitative registration performance compared with existing RIR techniques, such as the bifurcation structures method.
The scientific basis of organic farming

Abstract Organic farming is frequently dismissed as being unscientific, but this perception is based on a lack of understanding of the underlying concepts. Researchers in the organic field accept the scientific discipline whilst at the same time seeking new methodologies to explore the holistic character of the agricultural enterprise. Of central importance is the notion that health, food quality, and the nature of the farming system are inextricably linked. This paper reviews in scientific terms the key theoretical bases of the organic approach, and discusses the various methodologies used in this area. It is argued that a holistic approach to scientific investigations in agriculture is valid even if at present it is more of an aspiration than a reality.
A fuzzy expert system in evaluation for E-learning

With the flourish of online education and distance learning, it's become very important to make the evaluation in e-learning scientifically and objectively. This paper presents an intelligent fuzzy evaluation system based on our innovative evaluation method where management rules made by the experts are used to help, optimize and decide. On this basis, we develop an evaluation method and algorithm based on the fuzzy logic concepts and new information technologies. Thus, intelligent applications are possible if one wish to automate the management and decision while making an alarm system based on relevant indicators. Finally, we come up with an “expert system” that can provide some solutions to the problems of measurement theory. In addition, we present a concrete example to compare this method with the traditional one then draw conclusions on the effectiveness of this method.
C1q ablation exacerbates amyloid deposition: A study in a transgenic mouse model of ATTRV30M amyloid neuropathy

ATTRV30M amyloid neuropathy is a lethal autosomal dominant sensorimotor and autonomic neuropathy, caused by deposition of amyloid fibrils composed of aberrant transthyretin (TTR). Ages of onset and penetrance exhibit great variability and genetic factors have been implicated. Complement activation co-localizes with amyloid deposits in amyloidotic neuropathy and is possibly involved in the kinetics of amyloidogenesis. A candidate gene approach has recently identified C1q polymorphisms to correlate with disease onset in a Cypriot cohort of patients with ATTRV30M amyloid neuropathy. In the current study we use a double transgenic mouse model of ATTRV30M amyloid neuropathy in which C1q is ablated to elucidate further a possible modifier role for C1q. Amyloid deposition is found to be increased by 60% in the absence of C1q. Significant up regulation is also recorded in apoptotic and cellular stress markers reflecting extracellular toxicity of pre-fibrillar and fibrillar TTR. Our data further indicate that in the absence of C1q there is marked reduction of macrophages in association with amyloid deposits and thus less effective phagocytosis of TTR.
Introduction: A Systems View

Our goal in this series of four papers is a further refinement of a theory of interaction for psychoanalysis, with a specific focus on the concept of intersubjectivity. Psychoanalysis has addressed the concept of intersubjectivity primarily in the verbal/explicit mode. In contrast, infant research has addressed the concept of intersubjectivity in the nonverbal/implicit mode of action sequences, or procedural knowledge. We propose that an integration of explicit/linguistic with implicit/nonverbal theories of intersubjectivity is essential to a deeper understanding of therapeutic action in psychoanalysis today. To shed light on an implicit/nonverbal dimension of intersubjectivity in psychoanalysis, we include concepts from adult psychoanalysis, infant research, developmental systems theories, and nonverbal communication, particularly the distinction between implicit processing out of awareness and explicit processing at the declarative/verbal level. We conclude with an adult psychoanalytic case illustrating the integration of implicit/nonverbal forms of intersubjectivity into adult treatment.
Boosting with anti-models for automatic language identification

In this paper, we adopt the boosting framework to improve the performance of acoustic-based Gaussian mixture model (GMM) Language Identiﬁcation (LID) systems. We introduce a set of low-complexity, boosted target and anti-models that are estimated from training data to improve class separation, and these models are integrated during the LID backend process. This results in a fast estimation process. Experiments were performed on the 12-language, NIST 2003 language recognition evaluation classiﬁcation task using a GMM-acoustic-score-only LID system, as well as the one that combines GMM acoustic scores with sequence language model scores from GMM to-kenization. Classiﬁcation errors were reduced from 18.8% to 10.5% on the acoustic-score-only system, and from 11.3% to 7.8% on the combined acoustic and tokenization system.
Macroeconomic Principles and Monetary Policy

Using publicly available transcripts of FOMC meetings, Richmond Fed President Al Broaddus illustrates how he employed analytical macroeconomic principles on three occasions in the Open Market Committee. In a 1995 debate on inflation targeting, he argued that explicit targets help anchor price expectations and so enhance the Fed's ability to offset real disturbances without arousing fears of inflation or recession. In a 1994 discussion of foreign exchange intervention, he held that the Fed should avoid all attempts to influence the external value of the dollar since such attempts require policy actions that cast doubt on the Fed's commitment to price stability. And in a 1997 discussion of the implications of rising productivity growth for interest rate policy, he observed that the Fed must raise the real rate (the relative price of consumption tomorrow in terms of consumption sacrificed today) to induce consumers to shift their purchases to the future when goods, rendered abundant by accelerated productivity, will be cheaper than they are today.
Cleavage delay and abnormal morphogenesis in Lymnaea eggs after pulse treatment with azide of successive stages in a cleavage cycle.

Heat treatments of short duration of successive stages in a cleavage cycle of Lymnaea eggs differentially affect the division cycle and morphogenesis. Effects on the division cycle are most pronounced after a treatment during actual cleavage, at the end of interphase and during prometaphase. Abnormal morphogenesis is only found when a heat shock is applied during metaphase—anaphase stages; after treatment development proceeds up to the blastula stage. Development after the blastula stage, however, may be disturbed, leading to death, exogastrulation or malformations of the embryo. The results of these experiments indicate that successive division cycles represent well-defined steps of differing significance for later development (Geilenkirchen, 1966). Comparable results were obtained with LiCl (Geilenkirchen, 1967). It appeared that treatments of short duration between prophase of the second division and prophase of the third division cause exogastrulation whereas before and after this period of development LiCl rarely causes exogastrulation.
The molecular biology and clinical features of amyloid neuropathy

Neuropathy is often a major manifestation of systemic amyloidosis. It is most frequently seen in patients with hereditary transthyretin (TTR) amyloidosis, but is also present in 20% of patients with systemic immunoglobulin light chain (primary) amyloidosis. Familial amyloid polyneuropathy (FAP) is the most common form of inherited amyloidotic polyneuropathy, with clinical and electrophysiologic findings similar to neuropathies with differing etiologies (e.g., diabetes mellitus). Hereditary amyloidosis is an adult‐onset autosomal‐dominant disease with varying degrees of penetrance. It is caused by specific gene mutations, but demonstration that a patient has one such mutation does not confirm the diagnosis of amyloidosis. Diagnosis requires tissue biopsy with demonstration of amyloid deposits either by special histochemical stains or electron microscopy. Transthyretin amyloidosis is treated by liver transplantation, which eliminates the mutated transthyretin from the blood, but for some patients continued amyloid deposition can occur from wild‐type (normal) transthyretin. Presently, a study is ongoing to determine whether amyloid deposition can be inhibited by small organic molecules that are hypothesized to affect the fibril‐forming ability of transthyretin. Proposed gene therapy with antisense oligonucleotides (ASOs) to suppress hepatic transthyretin synthesis is effective in a transgenic mouse model but has not yet been tested in humans. Muscle Nerve, 2007
Cxc Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function

Leukocyte traffic through secondary lymphoid tissues is finely tuned by chemokines. We have studied the functional properties of a human T cell subset marked by the expression of CXC chemokine receptor 5 (CXCR5). Memory but not naive T cells from tonsils are CXCR5+ and migrate in response to the B cell–attracting chemokine 1 (BCA-1), which is selectively expressed by reticular cells and blood vessels within B cell follicles. Tonsillar CXCR5+ T cells do not respond to other chemokines present in secondary lymphoid tissues, including secondary lymphoid tissue chemokine (SLC), EBV-induced molecule 1 ligand chemokine (ELC), and stromal cell–derived factor 1 (SDF-1). The involvement of tonsillar CXCR5+ T cells in humoral immune responses is suggested by their localization in the mantle and light zone germinal centers of B cell follicles and by the concomitant expression of activation and costimulatory markers, including CD69, HLA-DR, and inducible costimulator (ICOS). Peripheral blood CXCR5+ T cells also belong to the CD4+ memory T cell subset but, in contrast to tonsillar cells, are in a resting state and migrate weakly to chemokines. CXCR5+ T cells are very inefficient in the production of cytokines but potently induce antibody production during coculture with B cells. These properties portray CXCR5+ T cells as a distinct memory T cell subset with B cell helper function, designated here as follicular B helper T cells (TFH).