Miracle-dz/UniFAR-FTUs huggingface dataset:
A Comparison of Transient Heat-Pump Cycle Simulations with Homogeneous and Heterogeneous Flow Models

This paper compares the effects of two different refrigerant flow modeling assumptions on the transien t performance of vapor-compression heat pump cycles. These simulations are developed in the Modelica modeling language, which uses an acausal, equation-oriented approach to describe physical systems. The effect of the flow assumptions and specific slip ratio correlations on both the equilibrium operating p oint and the transient behavior of the cycle are demonstrated through these simulations. It is shown that equivalent simulations with different slip ratio correlations each have different equilibrium mass inventories, and that some aspects of the transient system behavior exhibit differences between the representative simulations. The effect of the software implementation on the model performance is also discussed.
Infertility and cervical chlamydia trachomatis infections

Abstract. Of the 51 women examined for infertility, 19.6 per cent were found Chl. trachomatis culture‐positive. This differs, although not significantly, from the 9 per cent isolation rate among our general gynecological outpatients. The results suggest that Chl. trachomatis should be considered in women with unexplained infertility.
2-D high-frame-rate dynamic elastography using delay compensated and angularly compounded motion vectors: Preliminary results

This paper describes a new ultrasound-based system for high-frame-rate measurement of periodic motion in 2-D for tissue elasticity imaging. Similarly to conventional 2-D flow vector imaging, the system acquires the RF signals from the region of interest at multiple steering angles. A custom sector subdivision technique is used to increase the temporal resolution while keeping the total acquisition time within the range suitable for real-time applications. Within each sector, 1-D motion is estimated along the beam direction. The intraand inter-sector delays are compensated using our recently introduced delay compensation algorithm. In-plane 2-D motion vectors are then reconstructed from these delay-compensated 1-D motions. We show that Young's modulus images can be reconstructed from these 2-D motion vectors using local inversion algorithms. The performance of the system is validated quantitatively using a commercial flow phantom and a commercial elasticity phantom. At the frame rate of 1667 Hz, the estimated flow velocities with the system are in agreement with the velocity measured with a pulsed-wave Doppler imaging mode of a commercial ultrasound machine with manual angle correction. At the frame rate of 1250 Hz, phantom Young's moduli of 29, 6, and 54 kPa for the background, the soft inclusion, and the hard inclusion, are estimated to be 30, 11, and 53 kPa, respectively.
Value chains, networks and clusters: reframing the global automotive industry

In this article, we apply global value chain (GVC) analysis to recent trends in the global automotive industry, with special attention paid to the case of North America. We use the three main elements of the GVC framework—firm-level chain governance, power and institutions—to highlight some of the defining characteristics of this important industry. First, national political institutions create pressure for local content, which drives production close to end markets, where it tends to be organized nationally or regionally. Second, in terms of GVC governance, rising product complexity combined with low codifiability and a paucity of industry-level standards has driven buyer–supplier linkages toward the relational form, a governance mode that is more compatible with Japanese than American supplier relations. The outsourcing boom of the 1990s exacerbated this situation. As work shifted to the supply base, lead firms and suppliers were forced to develop relational linkages to support the exchange of complex uncodified information and tacit knowledge. Finally, the small number of hugely powerful lead firms that drive the automotive industry helps to explain why it has been so difficult to develop and set the industry-level standards that could underpin a more loosely articulated spatial architecture. This case study underlines the need for an open, scalable approach to the study of global industries.
Monoclonal Antibodies Recognizing the Non-Tandem Repeat Regions of the Human Mucin MUC4 in Pancreatic Cancer

The MUC4 mucin is a high molecular weight, membrane-bound, and highly glycosylated protein. It is a multi-domain protein that is putatively cleaved into a large mucin-like subunit (MUC4α) and a C-terminal growth-factor like subunit (MUC4β). MUC4 plays critical roles in physiological and pathological conditions and is aberrantly overexpressed in several cancers, including those of the pancreas, cervix, breast and lung. It is also a potential biomarker for the diagnosis, prognosis and progression of several malignancies. Further, MUC4 plays diverse functional roles in cancer initiation and progression as evident from its involvement in oncogenic transformation, proliferation, inhibition of apoptosis, motility and invasion, and resistance to chemotherapy in human cancer cells. We have previously generated a monoclonal antibody 8G7, which is directed against the TR region of MUC4, and has been extensively used to study the expression of MUC4 in several malignancies. Here, we describe the generation of anti-MUC4 antibodies directed against the non-TR regions of MUC4. Recombinant glutathione-S-transferase (GST)-fused MUC4α fragments, both upstream (MUC4α-N-Ter) and downstream (MUC4α-C-Ter) of the TR domain, were used as immunogens to immunize BALB/c mice. Following cell fusion, hybridomas were screened using the aforementioned recombinant proteins ad lysates from human pancreatic cell lines. Three anti MUC4α-N-Ter and one anti-MUC4α-C-Ter antibodies were characterized by several inmmunoassays including enzyme-linked immunosorbent assay (ELISA), immunoblotting, immunofluorescene, flow cytometry and immunoprecipitation using MUC4 expressing human pancreatic cancer cell lines. The antibodies also reacted with the MUC4 in human pancreatic tumor sections in immunohistochemical analysis. The new domain-specific anti-MUC4 antibodies will serve as important reagents to study the structure-function relationship of MUC4 domains and for the development of MUC4-based diagnostics and therapeutics.
EEG Markers for Characterizing Anomalous Activities of Cerebral Neurons in NAT (Neuronal Activity Topography) Method

A pair of markers, sNAT and vNAT, is derived from the electroencephalogram (EEG) power spectra (PS) recorded for 5 min with 21 electrodes (4-20 Hz) arranged according to the 10-20 standard. These markers form a new diagnosis tool “NAT” aiming at characterizing various brain disorders. Each signal sequence is divided into segments of 0.64 s and its discrete PS consists of eleven frequency components from 4.68 (3 × 1.56) Hz through 20.34 (13 × 1.56) Hz. PS is normalized to its mean and the bias of PS components on each frequency component across the 21 signal channels is reset to zero. The marker sNAT consists often frequency components on 21 channels, characterizing neuronal hyperactivity or hypoactivity as compared with NLc (normal controls). The marker vNAT consists of ten ratios between adjacent PS components denoting the over- or undersynchrony of collective neuronal activities as compared with NLc. The likelihood of a test subject to a specified brain disease is defined in terms of the normalized distance to the template NAT state of the disease in the NAT space. Separation of MCI-AD patients (developing AD in 12-18 months) from NLc is made with a false alarm rate of 15%. Locations with neuronal hypoactivity and undersynchrony of AD patients agree with locations of rCBF reduction measured by SPECT. The 2D diagram composed of the binary likelihoods between ADc and NLc in the two representations of sNAT and vNAT enables tracing the NAT state of a test subject approaching the AD area, and the follow-up of the treatment effects.
Using TAME to prove invariants of automata models: Two case studies

TAME is a special-purpose interface to PVS designed to support developers of software systems in proving properties of automata models. One of TAME's major goals is to allow a software developer who has basic knowledge of standard logic, and can do hand proofs, to use PVS to represent and to prove properties about an automaton model without first becoming a PVS expert. A second goal is for a human to be able to read and understand the content of saved TAME proofs without running them through the PVS proof checker. A third goal is to make proving properties of automata with TAME less costly in human time than proving such properties using PVS directly. Recent work by Romijn and Devillers et al., based on the I/O automata model, has provided the basis for two case studies on how well TAME achieves these goals. Romijn specified the RPC-Memory Problem and its solution, while Devillers et al. specified a tree identify protocol. Hand proofs of specification properties were provided by the authors. In addition, Devillers et al. used PVS directly to mechanize the specifications and proofs of the tree identify protocol. In one case study, the third author, a new TAME user with no previous PVS experience, used TAME to create PVS specifications of the I/O automata presented by Romijn and Devillers et al. and to check the hand proofs of invariant properties. The PVS specifications and proofs of Devillers et al. \hspace*{-. 03in} provide the basis for the other case study, which compares the TAME approach to an alternate approach which uses PVS directly.
Computer Three-Dimensional Reconstruction of the Sinoatrial Node

Background—There is an effort to build an anatomically and biophysically detailed virtual heart, and, although there are models for the atria and ventricles, there is no model for the sinoatrial node (SAN). For the SAN to show pacemaking and drive atrial muscle, theoretically, there should be a gradient in electrical coupling from the center to the periphery of the SAN and an interdigitation of SAN and atrial cells at the periphery. Any model should include such features. Methods and Results—Staining of rabbit SAN preparations for histology, middle neurofilament, atrial natriuretic peptide, and connexin (Cx) 43 revealed multiple cell types within and around the SAN (SAN and atrial cells, fibroblasts, and adipocytes). In contrast to atrial cells, all SAN cells expressed middle neurofilament (but not atrial natriuretic peptide) mRNA and protein. However, 2 distinct SAN cell types were observed: cells in the center (leading pacemaker site) were small, were organized in a mesh, and did not express Cx43. In contrast, cells in the periphery (exit pathway from the SAN) were large, were arranged predominantly in parallel, often expressed Cx43, and were mixed with atrial cells. An ≈2.5-million-element array model of the SAN and surrounding atrium, incorporating all cell types, was constructed. Conclusions—For the first time, a 3D anatomically detailed mathematical model of the SAN has been constructed, and this shows the presence of a specialized interface between the SAN and atrial muscle.
FPGA Implementation of a Real Time Maximum Likelihood Space-Time Decoder on a MIMO Software Radio Test Platform

This paper describes the concept, architecture, development and demonstration of a real time, maximum likelihood Alamouti decoder for a wireless 4-transmit 4-receiver multiple input and multiple output (MIMO) Smart Antenna Software Radio Test System (SASRATS) platform. It is implemented on a Xilinx Virtex 2 Pro Field Programmable Gate Array (FPGA). Hardware, firmware, use of the Xilinx Core Generator Intellectual Property modules and experimental verification of the decoder are discussed.
Examination findings and self-reported walking capacity in patients with lumbar spinal stenosis.

BACKGROUND AND PURPOSE Spinal stenosis is a common, often disabling, condition resulting from compression of the cauda equina and nerve roots. This study was designed to: (1) characterize the impairments of patients with lumbar spinal stenosis (LSS) and (2) to identify predictors of self-reported walking capacity. SUBJECTS Forty-three patients with symptomatic LSS, from 3 specialty clinics, were evaluated. Twenty-eight subjects (65%) were female. The subjects' median age was 73.6 years (mean=72.4, SD=10.3, range=45.7-90.7), and the median duration of low back pain was 24 months (mean=36.6, SD=41.6, range=0-216). METHODS Demographic data, medical history, and information about low back pain and symptoms (eg, numbness, tingling, and lower-extremity weakness) were collected using a standardized questionnaire and physical examination. RESULTS Twenty-two subjects (51%) had lower-extremity weakness, primarily of the extensor hallucis longus muscle. Thirty-five subjects (81%) had absent or decreased neurosensory responses (eg, pinprick, vibration, reflexes), and 28 subjects (66%) reported that they were unable to walk farther than 2 blocks. Women were more likely than men to report difficulties walking, as were subjects with abnormal Romberg test scores and those with greater pain during walking. DISCUSSION AND CONCLUSION Pain and balance problems appeared to be the primary factors limiting ambulation in our subjects with LSS.
Small Unruptured Intracranial Aneurysm Verification Study: SUAVe Study, Japan

Background and Purpose— The natural history and optimal management of incidentally found small unruptured aneurysms <5 mm in size remain unclear. A prospective study was conducted to determine the optimal management for incidentally found small unruptured aneurysms. Methods— From September 2000 to January, 2004, 540 aneurysms (446 patients) were registered. Four hundred forty-eight unruptured aneurysms <5 mm in size (374 patients) have been followed up for a mean of 41.0 months (1306.5 person-years) to date. We calculated the average annual rupture rate of small unruptured aneurysms and also investigated risk factors that contribute to rupture and enlargement of these aneurysms. Results— The average annual risks of rupture associated with small unruptured aneurysms were 0.54% overall, 0.34% for single aneurysms, and 0.95% for multiple aneurysms. Patient <50 years of age (P=0.046; hazard ratio, 5.23; 95% CI, 1.03 to 26.52), aneurysm diameter of ≥4.0 mm (P=0.023; hazard ratio, 5.86; 95% CI, 1.27 to 26.95), hypertension (P=0.023; hazard ratio, 7.93; 95% CI, 1.33 to 47.42), and aneurysm multiplicity (P=0.0048; hazard ratio, 4.87; 95% CI, 1.62 to 14.65) were found to be significant predictive factors for rupture of small aneurysms. Conclusions— The annual rupture rate associated with small unruptured aneurysms is quite low. Careful attention should be paid to the treatment indications for single-type unruptured aneurysms <5 mm. If the patient is <50 years of age, has hypertension, and multiple aneurysms with diameters of ≥4 mm, treatment should be considered to prevent future aneurysmal rupture.
Evaluation of O-POSSUM vs ASA and APACHE II scores in patients undergoing oesophageal surgery.

BACKGROUND AND AIMS Risk and prognostic scores quantify the patient's risk of death or complication according to the severity of his illness. The aim of this study was to evaluate the predictive accuracy of O-POSSUM vs ASA and APACHE II models on patients undergoing oesophageal surgery. MATERIAL AND METHOD In this observational retrospective study 55 patients were enrolled who had undergone surgical interventions of excision and reconstruction of the oesophagus for neoplastic oesophageal stenosis, in the Surgical Clinics (I and II) of the Clinical County Emergency Hospital Mures, between January 2011 and January 2014. By using patients file records after extracting the data we calculated the predictive mortality, according to the prognostic scores O-POSSUM, ASA and APACHE II and we analyzed its correlations with the postoperative evolution. We evaluated the discriminatory power of the three scores using the ROC (receiver-operating characteristic) curves. According to the cut-off value corresponding to each score, we compared the Kaplan Meier survival curves during the hospitalization period. RESULTS ROC curves analysis revealed that O-POSSUM had a better discriminatory power for mortality compared to the other two scores: AUC = 0.73 for O-POSSUM, AUC = 0.57 for APACHE II and AUC = 0.64 for ASA (p < 0.001). The cut-off value was statistically significant only in case of O-POSSUM, as it derives from the statistical analysis of the survival curves (p = 0.035). CONCLUSION O-POSSUM predicts mortality more accurately compared to ASA or APACHE II in patients undergoing oesophageal surgery.
Use of a Root Tumorigenesis Assay to Detect Genotypic Variation in Susceptibility of Thirty-four Cultivars of Pisum sativum to Crown Gall.

We developed a quantitative assay to measure tumorigenesis on roots and root crowns, the natural sites of Agrobacterium tumefaciens infection. Efficiency of tumor formation and tumor weight on seedlings of Pisum sativum ;Little Marvel' were directly proportional to the logarithm of inoculum concentration. Depth of wounding prior to inoculation also significantly influenced tumor weight but not efficiency. Mean weight of tumors that developed in response to inoculation with strain B6 varied significantly among 34 different commercial cultivars. Tumors on the most susceptible cultivar, Target, were more than tenfold heavier than those formed on the least susceptible cultivar, Sweet Snap. Efficiency of tumorigenesis on ;Sweet Snap' was also relatively low: only 64% of inoculated seedlings developed tumors compared with 89 to 100% efficiencies for all other cultivars.
Paraventricular hypothalamic oxytocinergic cells responding to noxious stimulation and projecting to the spinal dorsal horn represent a homeostatic analgesic mechanism

The participation of the hypothalamic paraventricular nucleus (PVN) in an endogenous central mechanism of analgesia has been observed using rats in various experimental procedures including electrophysiological and behavioral tests. However, little is known about the PVN neuronal responses to noxious stimulation. The only data available indicate a c‐fos increase after noxious visceral stimulations. Our electrophysiological recordings of single PVN cells showed that, out of 223 cells, 79 responded to noxious mechanical and/or thermal stimuli, and another 10 responsive cells were found in the Reuniers thalamic nucleus. These cells responded only to noxious stimuli mainly in the ipsilateral hind limb but we also observed cells responding to stimulation of both hind limbs and also the tail. Mechanical stimulation was most effective but some cells could respond to both mechanical and thermal noxious stimuli. Some of the responding PVN cells were identified by antidromic stimulation in the ipsilateral lumbar dorsal horn spinal cord. Finally, in order to document the nature of the neurotransmitter and the projection to the spinal cord of the PVN cells that responded to noxious stimulation, we used a juxtacellular approach to record and stain some neurons and found them to be oxytocinergic by immunofluorescence procedures. The PVN cells activated by noxious stimuli may suppress the peripheral incoming afferent A‐delta and C fibers, completing a circuit involved in diffuse endogenous analgesia. This mechanism strongly suggests that the PVN participates in a homeostatic mechanism involved in pain and analgesia.
IPv4/IPv6 transition using DNS64/NAT64: Deployment issues

IPv4 address space is almost exhausted. Usage of IPv6 address by client end hosts is limited due to small percentage of domain names that have IPv6 address. This paper presents practical testing in ISP that gives its users IPv6 addresses and provides them transparent access to both IPv4 and IPv6 Internet locations. DNS64/NAT64 translation mechanism is used for this purpose. Tests measure resource requirements on ISP side and effects on client experience. Results show that additional DNS64 processing causes no visible impact on DNS server CPU load. There is requirement for NAT64 device at ISP on path between IPv6 users and IPv4 Internet. Test results show that memory requirements for this device are small and achievable with standard hardware devices used by ISPs. Measured increase in RTT from IPv6 clients to IPv4 Internet is less than 2%. Conclusion is that DNS64/NAT64 translation system is viable solution for ISP.
A novel bagged particle filter for object tracking

In this paper, we propose a novel bagged particle filter framework to filtering the noise information from object trackers using generative model as well as the discriminative model. The framework makes use of objectness measurement for modeling observation likelihood and two powerful object detectors: the real-time L1 tracker and the TLD tracker combined to bagged trackers. By maxmazing the posterior of the proposed inference, inaccuracy information is filtered and more accuracy result from varying samples returned by different trackers is provided by the bagged particle filter. The experiment results suggest that the proposed particle filter is effective in combing the complementary nature of either the sparse tracking approach and the discriminative learning approach.
Physiological Induction of Regulatory Qa-1-Restricted CD8+ T Cells Triggered by Endogenous CD4+ T Cell Responses

T cell-dependent autoimmune diseases are characterized by the expansion of T cell clones that recognize immunodominant epitopes on the target antigen. As a consequence, for a given autoimmune disorder, pathogenic T cell clones express T cell receptors with a limited number of variable regions that define antigenic specificity. Qa-1, a MHC class I-like molecule, presents peptides from the variable region of TCRs to Qa-1-restricted CD8+ T cells. The induction of Vß-specific CD8+ T cells has been harnessed in an immunotherapeutic strategy known as the “T cell vaccination” (TCV) that comprises the injection of activated and attenuated CD4+ T cell clones so as to induce protective CD8+ T cells. We hypothesized that Qa-1-restricted CD8+ regulatory T cells could also constitute a physiologic regulatory arm of lymphocyte responses upon expansion of endogenous CD4+ T cells, in the absence of deliberate exogenous T cell vaccination. We immunized mice with two types of antigenic challenges in order to sequentially expand antigen-specific endogenous CD4+ T cells with distinct antigenic specificities but characterized by a common Vß chain in their TCR. The first immunization was performed with a non-self antigen while the second challenge was performed with a myelin-derived peptide known to drive experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. We show that regulatory Vß-specific Qa-1-restricted CD8+ T cells induced during the first endogenous CD4+ T cell responses are able to control the expansion of subsequently mobilized pathogenic autoreactive CD4+ T cells. In conclusion, apart from the immunotherapeutic TCV, Qa-1-restricted specialized CD8+ regulatory T cells can also be induced during endogenous CD4+ T cell responses. At variance with other regulatory T cell subsets, the action of these Qa-1-restricted T cells seems to be restricted to the immediate re-activation of CD4+ T cells.