Miracle-dz/UniFAR-FTUs huggingface dataset:
C8ORF88: A Novel eIF4E-Binding Protein

Translation initiation in eukaryotes is regulated at several steps, one of which involves the availability of the cap binding protein to participate in cap-dependent protein synthesis. Binding of eIF4E to translational repressors (eIF4E-binding proteins [4E-BPs]) suppresses translation and is used by cells to link extra- and intracellular cues to protein synthetic rates. The best studied of these interactions involves repression of translation by 4E-BP1 upon inhibition of the PI3K/mTOR signaling pathway. Herein, we characterize a novel 4E-BP, C8ORF88, whose expression is predominantly restricted to early spermatids. C8ORF88:eIF4E interaction is dependent on the canonical eIF4E binding motif (4E-BM) present in other 4E-BPs. Whereas 4E-BP1:eIF4E interaction is dependent on the phosphorylation of 4E-BP1, these sites are not conserved in C8ORF88 indicating a different mode of regulation.
Snakes of an urban-rural landscape in the central Andes of Colombia: species composition, distribution, and natural history

From 2005 to 2011, I studied thecomposition, distribution and natural history of an Andean urban-rural snake assemblageat the Cordillera Central of Colombia, based on three data sources: (1) examination ofspecimens in the MHN-UC [Museo de Historia Natural, Universidad de Caldas], (2)incidental encounters by author, and (3) collection of data by other researchers. Additionally,I provide natural history notes for the species involved. A total of 14 species, includingtwo subspecies of snakes, belonging to 12 genera and four families, have been found in thestudied area (municipality of Manizales, Caldas). Taking into account this total, 10 had atleast one record in the urban area, 13 in the rural area and 14 in forested areas. OnlyLiophis epinephelus bimaculatus was found exclusively in forest environment. Threespecies (21.4%) are apparently endemic to the region, six species (42.8%) correspond to afauna representative of the Tropical–Andean range of South America, four species (28.5%)are distributed from Central America to the tropical Andes, and only one species is widelydistributed in the whole continent. The snake assemblage in Manizales is mostly terrestrial,and in general, the species tend to be more active in the rainy periods of the year (mainlyfrom October–December), and most of them may occasionally be found in urban areas,mainly close to areas of vegetation such as crops and pastures.
A Comparative Evaluation of HbA1c Measurement Methods and Their Implications for Diabetes Management

In this study, we assessed the correlations between hemoglobin A1c (HbA1c) measurements obtained using three different diagnostic methods, namely reversed-phase cation-exchange chromatography, high-performance liquid chromatography, and lateral flow immunoassay (LIFA) with an AnyLab F instrument. HbA1c levels measured with the AnyLab F instrument and those measured with the HA8190V, HA8180, and D100 instruments were strongly correlated. High R-square values and low p-values indicated significant and reliable correlations, supporting the clinical interchangeability of these methods. Notably, demographic and clinical analyses revealed uniform HbA1c levels across age groups, suggesting minimal age-related variations in HbA1c levels in the cohort. This finding has implications for diabetes management strategies across different age groups, emphasizing the versatility of the AnyLab F instrument. Overall an average HbA1c level of 7.857% among diabetes mellitus-diagnosed participants suggests moderately elevated HbA1c levels, underscoring the need for improved diabetes management. Younger individuals exhibited lower HbA1c levels, potentially owing to heightened awareness and treatment plan adherence. Conversely, older adults had higher HbA1c levels, likely influenced by age-related changes and comorbidities. Larger sample sizes and a comprehensive evaluation of various measurement principles are needed to strengthen the findings herein. Additionally, exploring additional biomarkers and assessing LIFA performance in larger sample sets will advance the clinical utility of HbA1c measurements.
Shear Velocity Structure of Jordan from Explosion Seismic Data

Summary. Combined analysis of P- and S-wave data from seismic refraction lines in Jordan has led to the derivation of a Poisson’s ratio model for the crust. This model shows that the upper crust, including the sediments, has an average Poisson’s ratio of around 0.25, except beneath NW Jordan where the sediments have a high ratio of around 0.32. However, the lower crust below about 20 km depth has high Poisson’s ratios ranging from 0.29 to 0.32. These high Poisson’s ratios may be interpreted mineralogically in terms of high feldspar and low quartz content in the rocks (e.g. gneiss, amphibolite) of the lower crust or fluid phases in the form of separated penny-shaped inclusions.
The Emulsifying Properties, In Vitro Digestion Characteristics and Storage Stability of High-Pressure-Homogenization-Modified Dual-Protein-Based Emulsions

The droplet size, zeta potential, interface protein adsorption rate, physical stability and microrheological properties of high-pressure-homogenization (HPH)-modified, dual-protein-based whey–soy (whey protein isolate—soy protein isolate) emulsions containing different oil phase concentrations (5%, 10% and 15%; w/w) were compared in this paper. The in vitro digestion characteristics and storage stability of the dual-protein emulsions before and after HPH treatment were also explored. The results show that with an increase in the oil phase concentration, the droplet size and interface protein adsorption rate of the untreated dual-protein emulsions increased, while the absolute value of the zeta potential decreased. When the oil phase concentration was 10% (w/w), HPH treatment could significantly reduce the droplet size of the dual-protein emulsion, increase the interface protein adsorption rate, and improve the elasticity of the emulsion. Compared with other oil phase concentrations, the physical stability of the dual-protein emulsion containing a 10% (w/w) oil phase concentration was the best, so the in vitro digestion characteristics and storage stability of the emulsions were studied. Compared with the control group, the droplet size of the HPH-modified dual-protein emulsion was significantly reduced after gastrointestinal digestion, and the in vitro digestibility and release of free amino groups both significantly increased. The storage stability results show that the HPH-modified dual-protein emulsion showed good stability under different storage methods, and the storage stability of the steam-sterilized dual-protein emulsion stored at room temperature was the best. These results provide a theoretical basis for the development of new nutritional and healthy dual-protein liquid products.
The Western North Atlantic Region

The award-winning first volume in this 28-volume series. Complete coverage of the geology and geophysics of the western North Atlantic Ocean basin in 41 chapters, organized into 8 sections: Introduction; Present Accretion Axis; Regional Geology and Geophysics; Plate Tectonic Evolution; Surficial Sedimentation; Biofacies; Paleoceanography; and Resources and Law of the Sea. The editors received the 1986 Alan Berman Research Publication Award for this volume. Includes 11 plates, several in color.
HSP90β regulates EAAT2 expression and participates in ischemia‑reperfusion injury in rats

Cerebrovascular diseases (CVDs) have become a global public health problem and ischemia-reperfusion injury, the major cause of neurological impairment exacerbation, is closely related to excitotoxicity. The present study aimed to investigate the effects of changes in heat shock protein (HSP)90β expression and verify whether HSP90β regulates EAAT2 expression in a cerebral ischemia-reperfusion injury model. Healthy adult Sprague-Dawley (SD) male rats were used to establish a control group, sham-operated group, middle cerebral artery occlusion (MCAO) group, empty virus group and lentivirus group. A model of cerebral ischemia-reperfusion was established using the MCAO method. Lentivirus construction and injection were used to interfere with the expression of HSP90β. The modified neurological severity score was used to assess neurological deficits. Triphenyltetrazolium chloride staining was used to detect infarct areas. Immunofluorescence was used to detect HSP90β expression localization and the expression levels of HSP90β and EAAT2 were determined using western blotting and reverse transcription-quantitative PCR. An MCAO model was successfully established and it was found that HSP90β, but not HSP90α, was upregulated after MCAO. HSP90β expression coincided with astrocyte markers in the ischemic penumbra area, while no expression was observed in microglia. Inhibition of HSP90β expression improved neurological deficits and alleviated brain injury by increasing EAAT2 expression. These results suggested that HSP90β is involved in the process of cerebral ischemia-reperfusion injury in rats and that inhibition of HSP90β expression increases EAAT2 levels, conferring a neuroprotective effect in MCAO model rats.
Design of Wideband Filtering Patch Antenna Array With High Aperture Efficiency and Good Filtering Performance

In this work, a novel design concept of microstrip filtering array antennas is proposed and verified. In this concept, the radiation and filtering performance of the array will be first established by the filtering antenna element, and then optimized by the array topology and feeding structure with intrinsic filtering and resonant performance. This method achieves high-performance microstrip filtering array antennas without requiring additional filtering circuits, offering advantages over the existing design methods. To validate this concept, a microstrip filtering array was designed and fabricated. The filtering antenna element incorporated shorted pins, slots, and metal strips on the rectangular patch, resulting in satisfactory filtering and wideband radiation performance. Subsequently, the proposed filtering antenna elements were mirror-symmetrically placed to create a $1\times $ 2 array that exhibited superior filtering and radiation performance to the filtering element due to its unique array topology and feeding structure. Finally, a larger $2\times $ 2 filtering array was designed using a simple two-way power dividing network, which exhibited impressive results, such as an impedance bandwidth of 27.4%, high aperture efficiency (AE), and good filtering performance. Compared with the existing microstrip filtering array antennas, the proposed design provides a wide bandwidth, stable AE, and good filtering performance.
Analisis Arus Kas Operasi, Leverage, Likuiditas, Pertumbuhan Perusahaan terhadap Revaluasi Aset Tetap

The purpose of this study is to analyze the effect of operating cash flow, leverage, liquidity and company growth on fixed asset revaluation. In this study, there were 4 companies that met the criteria from a total observation of 46 companies with the object of research being transportation subsector companies listed on the Indonesia Stock Exchange (IDX) during the period 2014 to 2021. The results of this study indicate that the operating cash flow variable has a negative effect on revaluation. fixed assets, leverage has no effect on fixed asset revaluation. The variable liquidity has a negative effect on the revaluation of fixed assets. Taken together operating cash flow, Leverage, Liquidity and growth of the company significantly influence the revaluation of fixed assets. This research can be taken into consideration for investors and shareholders to be more careful in receiving financial statement information provided by companies in making investment decisions. For companies to be able to determine positive policies that can maintain business continuity and meet the expectations of shareholders.
Guiding Mothers About Early Detection and Addressing Speech Delay and Disorders Among Children in a Rural Setup

Introduction Speech is one of the most important milestones to be achieved by a growing child. The significance of being informed about different pediatric speech abnormalities, especially to mothers, allows them to help their children in cases of irregularities in the maturation in this domain. Aim and objectives The study aimed to assess and educate mothers on the important milestones of speech delay in children and make them address the issue and be aware of various corrective measures to treat the underlying conditions of speech disorders in children. The objectives of the study include understanding the pre-acquired knowledge of the mothers regarding the delay in speech in children, imparting knowledge regarding different speech disorders and their management, spreading awareness on how to seek help for various underlying causes of speech irregularities or delay, and to train the mothers into approaching the challenges in an orderly manner. Methods A study was conducted to guide rural mothers visiting the Obstetrics and Gynecology and Pediatric out-patient departments and Neonatal wards in a rural tertiary care hospital situated in the Sawangi Meghe village of Wardha City, Maharashtra, India, about the detection and treatment of children with disabilities of speech as early as possible. The mothers' knowledge was assessed before and after the study with the help of questionnaires, and basic understandable information on different types, causes, symptomatology, and management of speech delay and disorders among children was explained with the help of group discussions and posters. Results The motive behind this study was to be aware of facts known by the rural mothers, their actions on coming across such presentations by their children, cues that they would pick up, and the need to ask for help at the appropriate time were assessed and elaborated if not known by them. The Relative Learning Gain and Normalized Gain were calculated to be 76.43% and 0.74 (high gain), respectively, and out of the total subjects, 97.16% of mothers voted that this study proved helpful, and six mothers (4.23%) benefited with the intervention and were referred to experts for evaluation of their children. Conclusion Awareness in this field is necessary to manage children's development, especially by their mothers. Knowing the prevalence of knowledge in mothers may build an association with the prevalence of the recognized cases of speech disorders in children. Evaluation at different community levels may be conducted to gauge the need to impart required knowledge about speech disabilities in children to the maternal population. Future research and the impartation of knowledge to caregivers are vital to promote vigilant and systematic action to be taken regarding the proper growth of their children.
High-Resistance Connection Fault Diagnosis of SRM Based on Multisensor Calibrated Transformer With Shifted Windows

A fault diagnosis and classification method based on a multisensor calibrated transformer with shifted windows (MSSwin-T) is proposed to classify the high-resistance connection (HRC) fault of a switched reluctance motor (SRM). First, an experimental platform of an SRM-based electric vehicle drive system is built. The nonintrusive acquisition method is used to collect the three-channel current signal of the SRM stator winding as the HRC fault signal. Second, MSSwin-T, a feature extraction framework with the ability to establish global dependencies, is proposed to extract features that fully contain fault information. Finally, experimental results show that the classification accuracy of the proposed method is as high as 100% in the HRC fault diagnosis of SRM. Compared with traditional deep learning and transformer-based models, namely, UniFormer, CrossViT, vision transformer (ViT), and ResNet-18, the proposed method effectively improves the accuracy of HRC fault diagnosis. The accuracy of the proposed method is improved by 1.85%, 4.23%, 7.69%, and 9.31%, respectively, which can complete the classification and identification of the corresponding fault severity. Finally, the classification experiment with added noise verifies that the proposed MSSwin-T method has good anti-noise ability and robustness, indicating that this method is effective and feasible.
Maria Manturzewska’s model of the lifespan development of professional musicians in the light of recent research and cultural changes

The lifespan trajectory of musical achievement in the field of classical music and the factors that promote or hinder the development of talent in music are the focus of Manturzewska’s model of the lifespan development of professional musicians. This article aims to describe Manturzewska’s model briefly, relate it to recent research, and explore the extent to which it fits the diversity of musical careers of contemporary professional musicians. A brief depiction of the developmental model provides insight into the six developmental phases of the model and the factors that influence them. Recent research investigating talent development and career research in music suggests that Manturzewska’s theoretical model is largely consistent with findings from expertise research, research examining the determinants of musical development, and current models of talent development. The development of musicians with traditional careers as orchestral musicians in permanent, full-time employment or as successful soloists in contemporary musical culture is likely to be represented largely accurately in Manturzewska’s model. However, the diversity of typical portfolio careers, characterized by simultaneous irregular musical and non-musical activities in musical and non-musical fields, cannot be depicted in a single, more-or-less linear development model. Appropriate research, especially long-term studies that model the lifetime development of professional musicians (not only) in classical music, is lacking. Furthermore, Manturzewska’s model addresses important aspects that have been insufficiently studied by others, such as the development of professional musicians in the second half of life, and provides a sound and inspiring basis for future research.
New Functional Bionanocomposites by Combining Hybrid Host-Guest Systems with a Fully Biobased Poly(lactic acid)/Poly(butylene succinate-co-adipate) (PLA/PBSA) Binary Blend

In this study, we have developed innovative polymer nanocomposites by integrating magnesium-aluminum layered double hydroxide (LDH)-based nanocarriers modified with functional molecules into a fully biobased poly(lactic acid)/poly(butylene succinate-co-adipate) (PLA/PBSA) matrix. These LDH-based hybrid host-guest systems contain bioactive compounds like rosmarinic acid, ferulic acid, and glycyrrhetinic acid, known for their antioxidant, antimicrobial, and anti-inflammatory properties. The bioactive molecules can be gradually released from the nanocarriers over time, allowing for sustained and controlled delivery in various applications, such as active packaging or cosmetics. The morphological analysis of the polymer composites, prepared using a discontinuous mechanical mixer, revealed the presence of macroaggregates and nano-lamellae at the polymer interface. This resulted in an enhanced water vapor permeability compared to the original blend. Furthermore, the migration kinetics of active molecules from the thin films confirmed a controlled release mechanism based on their immobilization within the lamellar system. Scaling-up experiments evaluated the materials’ morphology and mechanical and thermal properties. Remarkably, stretching deformation and a higher shear rate during the mixing process enhanced the dispersion and distribution of the nanocarriers, as confirmed by the favorable mechanical properties of the materials.
Determination of stream-incision rate in the Appalachian plateaus by using cave-sediment magnetostratigraphy

Paleomagnetic dating of clastic fluvial sediments contained in caves within the walls of a steeply incised gorge allowed calculation of a maximum incision rate for the East Fork Obey River. The maximum incision rate for this major stream on the western margin of the Cumberland Plateau, north-central Tennessee, was found to be 0.06 m/ka. This rate was determined on the basis of the paleohydraulic relation between the caves and the surface stream, the presence of a normal-to-reverse polarity transition in clastic fluvial sediments deposited within the caves, and the vertical distribution of polarity found in sediments throughout the gorge. The dating results indicate that this highly developed fluviokarst, containing several of the longest known caves in the United States, developed wholly within the Pleistocene and Holocene.
Differential Expression of Circadian Clock Genes in the Bovine Neuroendocrine Adrenal System

Knowledge of circadian rhythm clock gene expression outside the suprachiasmatic nucleus is increasing. The purpose of this study was to determine whether expression of circadian clock genes differed within or among the bovine stress axis tissues (e.g., amygdala, hypothalamus, pituitary, adrenal cortex, and adrenal medulla). Tissues were obtained at an abattoir from eight mature nonpregnant Brahman cows that had been maintained in the same pasture and nutritional conditions. Sample tissues were stored in RNase-free sterile cryovials at −80 °C until the total RNA was extracted, quantified, assessed, and sequenced (NovaSeq 6000 system; paired-end 150 bp cycles). The trimmed reads were then mapped to a Bos taurus (B. taurus) reference genome (Umd3.1). Further analysis used the edgeR package. Raw gene count tables were read into RStudio, and low-expression genes were filtered out using the criteria of three minimum reads per gene in at least five samples. Normalization factors were then calculated using the trimmed mean of M values method to produce normalized gene counts within each sample tissue. The normalized gene counts important for a circadian rhythm were analyzed within and between each tissue of the stress axis using the GLM and CORR procedures of the Statistical Analysis System (SAS). The relative expression profiles of circadian clock genes differed (p < 0.01) within each tissue, with neuronal PAS domain protein 2 (NPAS2) having greater expression in the amygdala (p < 0.01) and period circadian regulator (PER1) having greater expression in all other tissues (p < 0.01). The expression among tissues also differed (p < 0.01) for individual circadian clock genes, with circadian locomotor output cycles protein kaput (CLOCK) expression being greater within the adrenal tissues and nuclear receptor subfamily 1 group D member 1 (NR1D1) expression being greater within the other tissues (p < 0.01). Overall, the results indicate that within each tissue, the various circadian clock genes were differentially expressed, in addition to being differentially expressed among the stress tissues of mature Brahman cows. Future use of these findings may assist in improving livestock husbandry and welfare by understanding interactions of the environment, stress responsiveness, and peripheral circadian rhythms.