Miracle-dz/UniFAR-FTUs huggingface dataset:
On second-order superhorizon perturbations in multifield inflationary models

We present a method for the study of second-order superhorizon perturbations in multifield inflationary models with nontrivial kinetic terms. We utilize a change of coordinates in field space to separate isocurvature and adiabatic perturbations generalizing previous results. We also construct second-order gauge-invariant variables related to them. It is found that with an arbitrary metric in field space the isocurvature perturbation sources the gravitational potential on long wavelengths even for 'straight' trajectories. The potential decouples from the isocurvature perturbations if the background fields' trajectory is a geodesic in field space. Taking nonlinear effects into account shows that, in general, the two types of perturbations couple to each other. This is an outline of a possible procedure to study nonlinear and non-Gaussian effects during multifield inflation.
Extrafollicular antibody responses

Summary: In adaptive antibody responses, B cells are induced to grow either in follicles where they form germinal centers or in extrafollicular foci as plasmablasts. Extrafollicular growth typically occurs in the medullary cords of lymph nodes and in foci in the red pulp of the spleen. It is not a feature of secondary lymphoid tissue associated with the internal epithelia of the body. All types of naïve and memory B cells can be recruited into extrafollicular responses. These responses are associated with immunoglobulin class switching but, at the most, only low‐level hypermutation.
Question Independent Grading using Machine Learning: The Case of Computer Program Grading

Learning supervised models to grade open-ended responses is an expensive process. A model has to be trained for every prompt/question separately, which in turn requires graded samples. In automatic programming evaluation specifically, the focus of this work, this issue is amplified. The models have to be trained not only for every question but also for every language the question is offered in. Moreover, the availability and time taken by experts to create a labeled set of programs for each question is a major bottleneck in scaling such a system. We address this issue by presenting a method to grade computer programs which requires no manually assigned labeled samples for grading responses to a new, unseen question. We extend our previous work [25] wherein we introduced a grammar of features to learn question specific models. In this work, we propose a method to transform those features into a set of features that maintain their structural relation with the labels across questions. Using these features we learn one supervised model, across questions for a given language, which can then be applied to an ungraded response to an unseen question. We show that our method rivals the performance of both, question specific models and the consensus among human experts while substantially outperforming extant ways of evaluating codes. We demonstrate the system single s value by deploying it to grade programs in a high stakes assessment. The learning from this work is transferable to other grading tasks such as math question grading and also provides a new variation to the supervised learning approach.
Prevalence and correlates of survival sex among runaway and homeless youth.

OBJECTIVE This study examined the prevalence and correlates of survival sex among runaway and homeless youths. METHODS A nationally representative sample of shelter youths and a multicity sample of street youths were interviewed. RESULTS Approximately 28% of street youths and 10% of shelter youths reported having participated in survival sex, which was associated with age, days away from home, victimization, criminal behaviors, substance use, suicide attempts, sexually transmitted disease, and pregnancy. CONCLUSIONS Intensive and ongoing services are needed to provide resources and residential assistance to enable runaway and homeless youths to avoid survival sex, which is associated with many problem behaviors.
Correctness of Routing Vector Protocols as a Property of Network Cycles

Most analyses of routing vector protocols, such as the Border Gateway Protocol (BGP), are conducted in the context of a single destination in a given network. In that context, for arbitrary routing policies, it is computationally intractable to determine whether or not a routing vector protocol behaves correctly. In this paper, we consider the common scenario where routing policies are specified independently of the destination. In this scenario, we demonstrate that the correctness of a routing vector protocol for all destinations in a given network equates to a property of routing policies around its cycles, designated strict absorbency, similarly to the way that the correctness of a distance vector protocol equates to cycles of positive length. A number of pragmatic conclusions can be derived from this theoretical result. For example, we show that all next-hop routing policies, which are popular in inter-domain routing and in the interconnection of routing instances, cannot fully exploit the physical redundancy of a network. As another example, we show how sibling autonomous systems of the Internet can share all routes between them without introducing oscillations into BGP.
Junction Temperature Control for More Reliable Power Electronics

The thermal stress of power electronic components is one of the most important causes of their failure. Proper thermal management plays an important role for more reliable and cost-effective energy conversion. As one of the most vulnerable and expensive components, power semiconductor components are the focus of this paper. Possible approaches to control the semiconductor junction temperature are discussed in this paper, along with the implementation in several emerging applications. The modification of the control variables at different levels (modulation, control, and system) to alter the loss generation or distribution is analyzed. Some of the control solutions presented in the literature, which showed experimentally that the thermal stress can be effectively reduced, are reviewed in detail. These results are often mission-profile dependent and the controller needs to be tuned to reach the desired cost-benefit tradeoff. This paper analyzes also the many open questions of this research area. Among them, it is worth highlighting that a verification of the actual lifetime extension is still missing.
Can modified casual speech reach the intelligibility of clear speech?

Clear speech is a speaking style adopted by speakers in an attempt to maximize the clarity of their speech and is proven to be more intelligible than casual speech. This work focuses on modifying casual speech to sound as intelligible as clear speech. First, we examine the role of speaking rate for intelligibility. Clear and casual speech signals are time-scale stretched, match-ing the average duration of the casual and clear speech respec-tively. Next, spectral shaping and dynamic range compression are considered for increasing the loudness of the original casual speech while keeping the power of signals unaffected. Subjective tests with speech-in-noise conditions using speech shaped noise at -3, 0, and 5 dB SNR show that clear speech with high speaking rate is less intelligible than the original clear speech but still more intelligible than the unmodiﬁed casual speech. However, the intelligibility score for the time-scaled modiﬁed casual speech is deteriorated. In contrast, the loudness ampli-ﬁcation considerably improved the intelligibility of the casual speech, reaching the scores of original clear speech. Objective measurements based on Speech Intelligibility Index (SII) are well correlated with the subjective test except for the time-scaled casual signal.
Cost-aware systemwide intrusion defense via online forensics and on-demand detector deployment

Balancing the coverage benefits of deploying multiple types of intrusion detection systems against their performance and false alarm costs is an important problem with practical ramifications for runtime security policy. In this position paper, we present an approach to "on-demand" deployment of intrusion detection systems by balancing detection coverage against cost and deploying an IDS only when it is needed. The proposed approach relies on often easy to detect symptoms of attacks, e.g., participation in a botnet or DDoS, and works backwards by iteratively deploying increasingly more localized and powerful detectors closer to the initial attack vector. We accomplish this by characterizing multiple IDS systems in a uniform framework based on their costs and detection capabilities and integrating them, for the first time, into an online system-wide forensics framework. We develop the basic elements of the framework and give an example of its envisioned operation.
Dilated eye examination screening guideline compliance among patients with diabetes without a diabetic retinopathy diagnosis: the role of geographic access

Objective To estimate the prevalence of, and factors associated with, dilated eye examination guideline compliance among patients with diabetes mellitus (DM), but without diabetic retinopathy. Research design and methods Utilizing the computerized billing records database, we identified patients with International Classification of Diseases (ICD)-9 diagnoses of DM, but without any ocular diagnoses. The available medical records of patients in 2007–2008 were reviewed for demographic and ocular information, including visits through 2010 (n=200). Patients were considered guideline compliant if they returned at least every 15 months for screening. Participant street addresses were assigned latitude and longitude coordinates to assess their neighborhood socioeconomic status (using the 2000 US census data), distance to the screening facility, and public transportation access. Patients not compliant, based on the medical record review, were contacted by phone or mail and asked to complete a follow-up survey to determine if screening took place at other locations. Results The overall screening compliance rate was 31%. Patient sociodemographic characteristics, insurance status, and neighborhood socioeconomic measures were not significantly associated with compliance. However, in separate multivariable logistic regression models, those living eight or more miles from the screening facility were significantly less likely to be compliant relative to those living within eight miles (OR=0.36 (95% CI 0.14 to 0.86)), while public transit access quality was positively associated with screening compliance (1.34 (1.07 to 1.68)). Conclusions Less than one-third of patients returned for diabetic retinopathy screening at least every 15 months, with transportation challenges associated with noncompliance. Our results suggest that reducing transportation barriers or utilizing community-based screening strategies may improve compliance.
Influence of Surface Modification and Content of Nanosilica on Dynamic Mechanical Properties of Epoxidized Natural Rubber Nanocomposites

Epoxidized natural rubber (ENR) nanocomposites were prepared in latex state by using unmodified and modified surface of nanosilica. Influence of surface modification and content of nanosilica on dynamic mechanical properties as a function of frequency (i.e., complex viscosity (η*), storage modulus (G ́) and loss modulus (G”) of ENR nanocomposites were investigated. It was found that surface modification of nanosilica improved rheological properties of nanosilica filled ENR nanocomposites. Moreover, greater nanosilica contents caused increasing of η*, G ́ and G”.
Recommending and evaluating choices in a virtual community of use

When making a choice in the absence of decisive first-hand knowledge, choosing as other like-minded, similarly-situ-ated people have successfully chosen in the past is a good strategy — in effect, using other people as filters and guides: filters to strain out potentially bad choices and guides to point out potentially good choices. Current human-computer interfaces largely ignore the power of the social strategy. For most choices within an interface, new users are left to fend for themselves and if necessary, to pursue help outside of the interface. We present a general his-tory-of-use method that automates a social method for informing choice and report on how it fares in the context of a fielded test case: the selection of videos from a large set. The positive results show that communal history-of-use data can serve as a powerful resource for use in interfaces.
Mineralocorticoid receptor suppresses cancer progression and the Warburg effect by modulating the miR‐338‐3p‐PKLR axis in hepatocellular carcinoma

Hormones and their corresponding receptors are vital in controlling metabolism under normal physiologic and pathologic conditions, but less is known about their roles in the metabolism of cancer. Using a small interfering RNA screening approach, we examined the effects of silencing 20 well‐known hormone receptors on the Warburg effect, specifically by measuring the production of lactate in four established hepatocellular carcinoma (HCC) cell lines. We found that silencing a variety of hormone receptors had effects on the production of this metabolite. Unexpectedly silencing of mineralocorticoid receptor (MR) significantly increased lactate production in all these HCC cell lines. Subsequent in vitro and in vivo studies showed that gain‐ and loss‐of‐function of MR significantly influenced HCC cellular proliferation, cell cycle distribution, and apoptosis. Furthermore, mechanistic studies revealed that MR as a transcriptional factor directly regulated the expression of miR‐338‐3p, suppressing the Warburg effects of HCC cells by targeting a key enzyme of glycolysis: pyruvate kinase, liver and red blood cells. Moreover, MR expression was significantly down‐regulated in 81% of HCC patient tissues, caused by both chromosome deletion and histone deacetylation. Low expression of MR in tumor tissues was associated with poor patient prognosis. The expression level of miR‐338‐3p was found to positively correlate with the expression of MR in HCC tissues and to inversely correlate with expression of the enzyme pyruvate kinase, liver and red blood cells. Conclusion: MR affects HCC development by modulating the miR‐338‐3p/pyruvate kinase, liver and red blood cells axis with an ability to suppress the Warburg effect. (Hepatology 2015;62:1145‐1159)
Approximating Optimal Estimation of Time Offset Synchronization With Temperature Variations

This paper addresses the problem of time offset synchronization in the presence of temperature variations, which lead to a non-Gaussian environment. In this context, regular Kalman filtering reveals to be suboptimal. A functional optimization approach is developed in order to approximate optimal estimation of the clock offset between master and slave. A numerical approximation is provided to this aim, based on regular neural network training. Other heuristics are provided as well, based on spline regression. An extensive performance evaluation highlights the benefits of the proposed techniques, which can be easily generalized to several clock synchronization protocols and operating environments.
New Functions of FrameSQL for Multilingual FrameNets

The Berkeley FrameNet Project (BFN) is making an English lexical database called FrameNet, which describes syntactic and semantic properties of an English lexicon extracted from large electronic text corpora (Baker et al., 1998). Other projects dealing with Spanish, German and Japanese follow a similar approach and annotate large corpora. FrameSQL is a web-based application developed by the author, and it allows the user to search the BFN database in a variety of ways (Sato, 2003). FrameSQL shows a clear view of the headwords grammar and combinatorial properties offered by the FrameNet database. FrameSQL has been developing and new functions were implemented for processing the Spanish FrameNet data (Subirats and Sato, 2004). FrameSQL is also in the process of incorporating the data of the Japanese FrameNet Project (Ohara et al., 2003) and that of the Saarbrücken Lexical Semantics Acquisition Project (Erk et al., 2003) into the database and will offer the same user-interface for searching these lexical data. This paper describes new functions of FrameSQL, showing how FrameSQL deals with the lexical data of English, Spanish, Japanese and German seamlessly.
Influence of Wrestling on the Physiological and Skill Demands of Small-Sided Games

Gabbett, TJ, Jenkins, DG, and Abernethy, B. Influence of wrestling on the physiological and skill demands of small-sided games. J Strength Cond Res 26(1): 113–120, 2012—This study investigated the influence of wrestling on the physiological and skill demands of small-sided games. Twenty-eight elite rugby league players ([mean ± SE] age, 21.6 ± 0.5 years) participated in this within-subject crossover study. On day 1, 14 players played 2, 8-minute small-sided games, whereas the remaining 14 players played identical games with intermittent wrestling throughout. Each game was separated by 90 seconds. On day 2, the groups were crossed over. Movement was recorded by a global positioning system unit (miniMaxX, Catapult Innovations, Melbourne, Australia), sampling at 5 Hz. Each small-sided game was filmed to track the number of possessions and the number and quality of disposals. The games without wrestling resulted in a greater (p < 0.05) total distance covered (2,475 ± 31 vs. 1,964 ± 27 m) and greater distance covered in low (930 ± 19 vs. 842 ± 19 m), moderate (1,120 ± 28 vs. 752 ± 26 m), high (332 ± 16 vs. 240 ± 12 m), and very-high (24 ± 4 vs. 15 ± 3 m) velocity movement intensities. Conversely, the games with wrestling resulted in a significantly greater (p < 0.05) distance covered in mild, moderate, and maximal accelerations and a greater number of repeated high-intensity effort bouts (2.1 ± 0.2 bouts vs. 0.2 ± 0.1 bouts). No significant differences (p > 0.05) were detected between games with and without wrestling for the total number of involvements, receives, passes, effective passes, ineffective passes, and disposal efficiency. The results of this study demonstrate that intermittent wrestling reduces the running demands but increases the repeated high-intensity effort demands of small-side games. Furthermore, these physiological changes occur without compromising the volume of skill executions, the number of errors, or disposal efficiency. From a practical perspective, these results suggest that intermittent wrestling may be a useful supplement to small-sided games to concurrently train repeated-effort ability and skills under game-specific fatigue.
Anagliptin ameliorates albuminuria and urinary liver-type fatty acid-binding protein excretion in patients with type 2 diabetes with nephropathy in a glucose-lowering-independent manner

Objective The objective of this study is to elucidate the effect of anagliptin on glucose/lipid metabolism and renoprotection in patients with type 2 diabetic nephropathy. Methods Twenty-five patients with type 2 diabetic nephropathy received anagliptin 200 mg/day for 24 weeks, and 20 patients who were switched to anagliptin from other dipeptidyl peptidase-4 (DPP-4) inhibitors were analyzed regarding primary and secondary endpoints. The primary endpoint was change in hemoglobin A1c (HbA1c) during treatment with anagliptin. Additionally, we evaluated changes in lipid data (low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol and triglyceride), blood pressure (BP), urinary albumin to creatinine ratio (UACR), liver-type fatty acid-binding protein to creatinine ratio (ULFABP) and renal function (estimated glomerular filtration rate and serum cystatin C) as secondary endpoints. Results After switching to anagliptin from other DPP-4 inhibitors, the levels of HbA1c in the 20 participants showed no significant change, 7.5%±1.2% at 24 weeks compared with 7.3%±0.9% at baseline. The levels of the log10-transformed UACR were significantly reduced from 1.95±0.51 mg/g creatinine (Cr) at baseline to 1.76±0.53 mg/g Cr at 24 weeks after anagliptin treatment (p<0.01). The percentage change in the UACR (Δ%UACR) from baseline to 24 weeks was also significantly lower by −10.6% (p<0.001). Lipid data, systolic BP and renal function were not changed during anagliptin treatment. Additionally, ULFABP in eight participants, who had ≥5 µg/g Cr at baseline, was significantly decreased from baseline (8.5±2.8 µg/g Cr) to 24 weeks (3.1±1.7 µg/g Cr, p<0.01) after anagliptin treatment, and the percentage change in the ULFABP during anagliptin treatment was −58.1% (p<0.001). Conclusions Anagliptin induced no significant change in HbA1c, lipid data, systolic BP and renal function. However, anagliptin reduced the UACR and ULFABP, although without a corresponding change in HbA1c, indicating direct action of anagliptin on renoprotection in patients with type 2 diabetic nephropathy.
Abnormal Condition Monitoring of Workpieces Based on RFID for Wisdom Manufacturing Workshops

Radio Frequency Identification (RFID) technology has been widely used in many fields. However, previous studies have mainly focused on product life cycle tracking, and there are few studies on real-time status monitoring of workpieces in manufacturing workshops. In this paper, a wisdom manufacturing model is introduced, a sensing-aware environment for a wisdom manufacturing workshop is constructed, and RFID event models are defined. A synthetic data cleaning method is applied to clean the raw RFID data. The Complex Event Processing (CEP) technology is adopted to monitor abnormal conditions of workpieces in real time. The RFID data cleaning method and data mining technology are examined by simulation and physical experiments. The results show that the synthetic data cleaning method preprocesses data well. The CEP based on the Rifidi® Edge Server technology completed abnormal condition monitoring of workpieces in real time. This paper reveals the importance of RFID spatial and temporal data analysis in real-time status monitoring of workpieces in wisdom manufacturing workshops.
Prevalence and Risk Factors of Cerebral Microbleeds: An Update of the Rotterdam Scan Study

Background and Purpose— We previously reported on the high prevalence of cerebral microbleeds (CMBs) in community-dwelling people aged 60 years and older. Moreover, we found that their spatial distribution likely reflects differences in underlying etiology. We have since almost quadrupled the number of participants in our study and expanded it to include persons of 45 years and older. We examined the prevalence and determinants of microbleeds in this larger and younger cohort from the general population. Methods— In 3979 persons (mean age, 60.3 years), we performed brain MRI at 1.5T, including a sequence optimized for visualization of CMBs. Associations between APOE genotype, cardiovascular risk factors, and markers of cerebrovascular disease with the presence and location of CMBs were assessed by multiple logistic regression adjusted for age, sex, and relevant confounders. Results— Microbleed prevalence gradually increased with age, from 6.5% in persons aged 45 to 50 years to 35.7% in participants of 80 years and older. Overall, 15.3% of all subjects had at least 1 CMB. Cardiovascular risk factors and presence of lacunar infarcts and white matter lesions were associated with microbleeds in a deep or infratentorial region, whereas APOE ϵ4 and diastolic blood pressure were related to microbleeds in a strictly lobar location. Conclusions— Findings in this larger population are in line with our previous results and, more importantly, extend these to a younger age group. CMBs are already present at middle age, and prevalence rises strongly with increasing age. We confirmed that determinants of the presence of cerebral microbleeds differ according to their location in the brain.