Miracle-dz/UniFAR-FTUs huggingface dataset:
Biological Response of Human Cancer Cells to Ionizing Radiation in Combination with Gold Nanoparticles

Simple Summary Various types of metallic nanoparticles and especially gold nanoparticles (AuNPs) have been utilized in radiation studies to enhance the radiosensitization of cancer cells while minimizing detrimental effects in normal tissue. The aim of our study was to investigate the biological responses of various human cancer cells to gold-nanoparticle-induced radiosensitization. This was accomplished by using different AuNPs and several techniques in order to provide valuable insights regarding the multiple adverse biological effects, following ionizing radiation (IR) in combination with AuNPs. Insightful methodologies such as transmission electron microscopy were employed to identify comprehensively the complexity of the biological damage occurrence. Our findings confirm that AuNP radiosensitization may occur due to extensive and/or complex DNA damage, cell death, or cellular senescence. This multiparameter study aims to further elucidate the biological mechanisms and at the same time provide new information regarding the use of AuNPs as radiosensitizers in cancer treatment. Abstract In the context of improving radiation therapy, high-atomic number (Z) metallic nanoparticles and, more importantly, gold-based nanostructures are developed as radiation enhancers/radiosensitizers. Due to the diversity of cell lines, nanoparticles, as well as radiation types or doses, the resulting biological effects may differ and remain obscure. In this multiparameter study, we aim to shed light on these effects and investigate them further by employing X-irradiation and three human cancer cell lines (PC3, A549, and U2OS cells) treated by multiple techniques. TEM experiments on PC3 cells showed that citrate-capped AuNPs were found to be located mostly in membranous structures/vesicles or autophagosomes, but also, in the case of PEG-capped AuNPs, inside the nucleus as well. The colony-forming capability of cancer cells radiosensitized by AuNPs decreased significantly and the DNA damage detected by cytogenetics, γH2AX immunostaining, and by single (γH2AX) or double (γH2AX and OGG1) immunolocalization via transmission electron microscopy (TEM) was in many cases higher and/or persistent after combination with AuNPs than upon individual exposure to ionizing radiation (IR). Moreover, different cell cycle distribution was evident in PC3 but not A549 cells after treatment with AuNPs and/or irradiation. Finally, cellular senescence was investigated by using a newly established staining procedure for lipofuscin, based on a Sudan Black-B analogue (GL13) which showed that based on the AuNPs’ concentration, an increased number of senescent cells might be observed after exposure to IR. Even though different cell lines or different types and concentrations of AuNPs may alter the levels of radiosensitization, our results imply that the complexity of damage might also be an important factor of AuNP-induced radiosensitization.
Introduction to 1-summability and resurgence

This text is about the mathematical use of certain divergent power series. The rst part is an introduction to 1-summability. The denitions rely on the formal Borel transform and the Laplace transform along an arbitrary direction of the complex plane. Given an arc of directions, if a power series is 1-summable in that arc, then one can attach to it a Borel-Laplace sum, i.e. a holomorphic function dened in a large enough sector and asymptotic to that power series in Gevrey sense. The second part is an introduction to Ecalle’s resurgence theory. A power series is said to be resurgent when its Borel transform is convergent and has good analytic continuation properties: there may be singularities but they must be isolated. The analysis of these singularities, through the so-called alien calculus, allows one to compare the various BorelLaplace sums attached to the same resurgent 1-summable series. In the context of analytic dierence-or-dier ential equations, this sheds light on the Stokes phenomenon. A few elementary or classical examples are given a thorough treatment (the Euler series, the Stirling series, a less known example by Poincar e). Special attention is devoted to non-linear operations: 1-summable series as well as resurgent series are shown to form algebras which are stable by composition. As an application, the resurgent approach to the classication of tangent-to-identity germs of holomorphic dieomorphisms in the simplest case is included. An example of a class of non-linear dierential equations giving rise to resurgent solutions is also presented. The exposition is as self-contained as can be, requiring only some familiarity with holomorphic functions of one complex variable.
Experimentation capability for a circular economy: a practical guide

Purpose To meet their ambitious targets for a circular economy, multinationals need to speed up their innovation efforts. This requires experimentation capability. But it is not clear what this capability entails, and how companies can build it. The purpose of this paper is to give companies guidance on how they might develop experimentation capability for the circular economy. Design/methodology/approach We conduct in-depth interviews with innovators in frontrunner multinationals, H&M, IKEA and Philips. We use the Gioia method to analyse our data. Findings This article identifies novel institutional, strategic, and operational actions that build experimentation capability for a circular economy. Practical implications The identified actions help innovation managers experiment and speed up their innovation efforts for a circular economy. Social implications To reverse environmental degradation, multinationals need to transform their dominant linear take-make-waste business models. This research provides actions that help them organize this transformation. Originality/value This article is based on extensive research with leading multinationals and reveals novel insights on how to innovate for a circular economy.
Effect of unequal injection rates on asymmetric exclusion processes with junction

In this paper, we investigate the effect of unequal injection rates on totally asymmetric simple exclusion processes (TASEPs) with a 2-input 1-output junction and parallel update. A mean-field approach is developed to deal with the junction that connects two sub-chains and the single main chain. We obtain the stationary particle currents, density profiles and phase diagrams. Interestingly, we find that the number of stationary-state phases is changeable depending on the value of α1 (α1 is the injection rate on the first sub-chain). When α1 > 1/3, there are seven stationary-state phases in the system, however when α1 < 1/3, only six stationary-state phases exist in the system. The theoretical calculations are shown to be in agreement with Monte Carlo simulations.
Kinetic network models to study molecular self-assembly in the wake of machine learning

Self-assembly provides a powerful tool to fabricate advanced materials through the bottom-up approach. Understanding the kinetics of self-assembly would thus greatly help achieve precise control in designing elegant structures for advanced materials. However, it is difficult to elucidate the kinetic details of self-assembly at a molecular level. Kinetic network models (KNMs) based on molecular dynamics (MD) simulations have the potential to elucidate the ensemble of self-assembly pathways that would be difficult to obtain experimentally. In this article, we discuss several major challenges of applying KNMs to study self-assembly and review the recent development of machine learning approaches to address these challenges. First, it is important to consider permutations in the molecular index to properly describe self-assembled structures containing identical monomers. To address this issue, physical coordinates invariant to permutations can be adopted (e.g., aggregate size and morphology in the self-assembly of nanoparticles, and the number of rhombic and hexagonal ice in ice nucleation on a surface). More recently, self-assembled structures are described as undirected graphs, which can be further adopted in the Graph Neural Network to identify metastable states. Second, KNMs of self-assembly processes may yield numerous parallel pathways with comparable probabilities, making it difficult to understand the major mechanisms of self-assembly. To address this challenge, the path lumping algorithm is developed to group numerous transition pathways obtained from transition path theory into metastable path channels according to their kinetic similarity. Finally, reinforcement learning-based methods open a window of opportunities for the rational design of kinetic pathways to control the self-assembly process. In the wake of machine learning, we anticipate that KNMs have the potential to be widely applied in molecular self-assembly studies and facilitate the design of new materials. Graphical abstract
Significant Role of the Human Development Index in Alleviating Poverty

During the pandemic, most of the population not only experienced a decrease in income but also experienced losses in various dimensions of life, such as health, education, and a decent standard of living. So far, poverty is measured by expenditure, and it has not been able to capture all of the above dimensions. Assessing multidimensional poverty provides more specific information so that policies are more relevant. This study evaluates factors and policies related to poverty in Indonesia, especially during the pandemic, using pooled data regression. The variables used are the Human Development Index (HDI), gross domestic product (GDP), population, and wages in 34 provinces in Indonesia from 2012 to 2021. The results show that HDI has a significant negative influence and population has a positive and significant influence on poverty. In Indonesia, the pandemic reduced people's incomes, which increased poverty. Unlike other studies, this study shows that the 2020 wage stagnation policy implemented by the government effectively reduces poverty in Indonesia. During this period of economic recovery, the policies for providing employment and meeting public needs are believed to reduce the level of poverty.
Distributed consensus control of nonlinear multi‐agent systems with sensor uncertainty

This article focuses on the distributed consensus control problem for nonlinear multi‐agent systems subject to sensor uncertainty. To be specific, we study nonlinear multi‐agent systems of lower or upper triangular structure with unknown growth rate and sensor uncertainty. A new time‐varying gain approach is proposed to construct observers as well as distributed output‐feedback controllers. By selecting suitable design parameters, the leader‐follower consensus of nonlinear multi‐agent systems is achieved. Different from the existing results, a time‐varying function in a logarithmic form is introduced to deal with unknown growth rate. Moreover, a monotonically increasing time‐varying function is constructed to cope with uncertain sensor sensitivity. Two simulation examples are provided to demonstrate the effectiveness of the proposed distributed consensus control algorithms.
New data on spiders (Arachnida: Aranei) of the Central Yamal Peninsula, with notes on biotopic preferences of the dominant species

is the ABSTRACT: Studying the local fauna of spiders in the vicinity of the Seyakha village (Yamal Peninsula, Siberian Arctic), I identified a total of 47 species be-longing to seven families. Five species ( Agyneta decora , A. ripariensis , Masikia caliginosa , Metopobactrus prominulus , and Walckenaeria clavicornis ) have been recorded for the fauna of Yamal for the first time. The fauna of the Southern, Central, and Northern Yamal differ in species richness (comprised of a total of 165, 61, and 36 species, respectively). I compared the effectiveness of estimations of the species richness for spiders at high latitudes using pitfall traps and a sifter and found no significant differences between these methods. The composition of the dominant species differed between the sample sets collected using pitfall traps and a sifter, although all of these species were present in both sample sets. I found no clear biotopic preferences for populations of the majority of dominant spider species in the Central Yamal.
Efeito escola a partir de indicadores educacionais: análise entre escolas públicas e privadas no ENEM

Neste artigo analisou-se a relação entre os indicadores educacionais e o desempenho em matemática de alunos de escolas públicas e privadas no Exame Nacional do Ensino Médio. Utilizou-se uma modelagem multinível com indicadores no nível da escola, a fim de medir o efeito no desempenho, além de fazer comparações descritivas por dependência administrativa. Os modelos ajustados foram controlados por variáveis da família e individuais no nível aluno. Encontrou-se que o efeito escola foi de 13% para as escolas privadas e 9% para as públicas, o que indica que os fatores que independem das ações pedagógicas e de gestão da escola têm uma grande contribuição no desempenho, tanto para os estudantes de escolas privadas quanto os de escolas públicas.
Intrinsieke arbeidsorintatie en uitputting bij werknemers

Een intrinsieke arbeidsorientatie betekent dat een werknemer veel belang hecht aan de inhoudelijke aspecten van werk: zelfstandigheid, uitdaging en de mogelijkheden tot zelfontplooiing. De vraag is of intrinsieke arbeidsorientatie als persoonsgebonden hulpbron een rol speelt in het uitputtingsproces. Om die vraag te beantwoorden is een onderzoeksmodel ontwikkeld dat inzichten uit het Job Demands-Resources-model, het Vitaminemodel van Warr en de conservation of resources-theorie van Hobfoll integreert. De analyses zijn uitgevoerd op basis van een omvangrijke, heterogene steekproef onder de Nederlandse beroepsbevolking. De analyseresultaten bevestigen de hypotheses: een intrinsieke arbeidsorientatie hangt samen met minder uitputting, dempt de uitputtingsgevolgen van te hoge werkdruk en versterkt het uitputtingsreducerende effect van veel autonomie en ontwikkelingsmogelijkheden. Op basis van deze onderzoeksresultaten wordt geconcludeerd dat meer onderzoek naar de rol van deze en andere persoonsgebonden hulpbronnen in het uitputtingsproces zonder meer wenselijk is. In plaats van uitputting wordt ook wel de term stress gehanteerd.
LogGrep: Fast and Cheap Cloud Log Storage by Exploiting both Static and Runtime Patterns

In cloud systems, near-line logs are mainly used for debugging, which means they prefer a low query latency for a better user experience, and like any other logs, they also prefer a low overall cost including storage cost to store compressed logs and computation cost to compress logs and execute queries. This paper proposes LogGrep, the first log compression and query tool that structurizes and organizes log data properly in fine-grained units by exploiting both static and runtime patterns. It first parses logs into variable vectors by exploiting static patterns and then extracts runtime pattern(s) automatically within each variable vector with a novel extraction method. Based on these runtime patterns, LogGrep further decomposes the variable vectors into fine-grained units called "Capsules" and stamps each Capsule with a summary of its values. During the query process, LogGrep can avoid decompressing and scanning Capsules that cannot possibly match the keywords, with the help of the extracted runtime patterns and the Capsule stamps. We evaluate LogGrep on 21 types of logs from the production environment of Alibaba Cloud, and 16 types of logs from the public datasets. The results show that LogGrep can reduce query latency and overall cost by an order of magnitude compared to state-of-the-art works. Such results have confirmed that exploiting both static and runtime patterns to structurize logs can achieve fast and cheap cloud log storage.
Ab-Initio Studies of the Micromechanics and Interfacial Behavior of Al 3 Y|fcc-Al

: In this paper, an Ab-initio study was employed to study the properties of interfaces of Al 3 Y|Al. The interface strength, shear strength, structural stability, electronic density, bonding characteristics, stacking fault energy, and plasticity were all investigated. The interface with the stacking style of ABab or CBAcba has the greatest interface strength. The Al 3 Y(111)|Al(111) interface has the highest tensile stress of 13.39 GPa for rigid stretching; and 9.39 GPa for relaxation stretching. In the stretching process, the Al 3 Y(111)|Al(111) interface is prone to break on the Al 3 Y side. However, the Al 3 Y(010)|Al(010) and Al 3 Y(110)|Al(110) interface systems tend to fracture at the interface and Al side, respectively. Moreover, the differential charge density, electron localization function, and partial density of states (PDOS) demonstrate the newly formed chemical bonds at the interface, and the chemical bonds were formed by s-p or s-p-d hybrid orbitals. According to the Rice ratio and shear stress, these interfaces were found to be plastic and the Al 3 Y(111)|Al(111) interface has the best plasticity. This is significant because the formed interfaces are all advanced structure materials, which can be potentially used in automobile and aeronautical fields, even in some special industries. The partial density of the states shows that s-p and s-p-d hybrid orbitals are formed among the Al and Y atoms at the interface.
Evaluating Mindfulness on Loneliness in an Older Adult Evaluating Mindfulness on Loneliness in an Older Adult Population Population

Problem: Loneliness is a widespread public health concern and has negatively impacted mortality and health outcomes among older adults. This quality improvement project’s purpose was to evaluate mindfulness on loneliness and quality of life among adults aged 65 years and older, participating in a weekly befriending socialization program. Methods: A descriptive cohort design was utilized to assess loneliness pre-and post-implementation of a mindfulness telephone line over three months. A convenience sample of 22 older adults enrolled in a befriending socialization program was used. The Iowa Model of Evidence-Based Practice framework was applied to guide the implementation of a practice change and evaluate its impact on healthcare outcomes. Results: Participation in mindfulness was independent of post-implementation perceived loneliness ( p = .697) and quality of life ( p = .711). No difference was noted between the post-implementation mean loneliness scores among the mindfulness participation ( M = 3.57, SD = 2.70) and no participation groups ( M = 3.53, SD = 1.88), t (20)= -0.04, p = . 970. Mindfulness participation did not have a significant difference for the mean loneliness scores in the pre- ( M = 3.86, SD = 2.54) and post-implementation screenings ( M = 3.57, SD = 2.70), t (6)= 0.79, p = . 457. A mean decrease from 3.86 to 3.57 is clinically significant. Implications for Practice: Mindfulness meditation may provide a positive impact on the older adult population. Telephone-based mindfulness meditations have the potential to reduce anxiety and stress while improving focus and sleep, as well as creating the daily habit of deep breathing and mindfulness. The daily activity of telephone-based mindfulness could supplement weekly befriending socialization programs for older adults.
Optimal H/sub 2//l/sub 1/ control: the SISO case

Considers the problem of minimizing the H/sub 2/-norm of the closed loop map while maintaining its l/sub 1/-norm at a prescribed level. The problem is analyzed in the case of discrete-time, SISO closed loop maps. Utilizing duality theory, it is shown that the optimal solution is unique and has a finite impulse response. A finite step procedure is given for the construction of the exact solution. This procedure consists of solving a finite number of quadratic programming problems which can be performed using standard methods. Finally, continuity properties of the optimal solution with respect to changes in the l/sub 1/-constraint are established. <<ETX>>
Some remarks on likelihood factorization

Various types of likelihood factorization are reviewed and some general statistical consequences noted. In one broad class there is noniterative asymptotically efficient combination of information across factors via generalized least squares. This is used to discuss missing information in simple binary problems. It is shown that with observations on a 2 ? 2 table supplemented by independent observations on each margin the maximum likelihood estimate of the odds ratio differs from that based on the complete table but is not asymptotically more efficient.
EXTENDED X-RAY EMISSION FROM A QUASAR-DRIVEN SUPERBUBBLE

We present observations of extended, 20 kpc scale soft X-ray gas around a luminous obscured quasar hosted by an ultraluminous infrared galaxy caught in the midst of a major merger. The extended X-ray emission is well fit as a thermal gas with a temperature of kT ≈280 eV and a luminosity of LX ≈ 1042 erg s−1 and is spatially coincident with a known ionized gas outflow. Based on the X-ray luminosity, a factor of ∼10 fainter than the [O iii] emission, we conclude that the X-ray emission is either dominated by photoionization, or by shocked emission from cloud surfaces in a hot quasar-driven wind.
A Second Compact Radio Component Detected in the LMC HII Region N159

Abstract The Australia Telescope Compact Array has been used for observations, with arcsecond resolution, of the HII region N159 in the Large Magellanic Cloud. Images at 5 GHz reveal a second compact continuum component which has no obvious counterpart at optical and infrared wavelengths. Observations of HI 10α recombination-line emission, and HI and H2CO absorption, suggest that the object is a compact HII region embedded in a dense obscuring cloud on the edge of N159.
Theory and Phenomenology of Dirac Leptogenesis

Dirac leptogenesis, in which neutrinos are purely Dirac and develop small but nonzero effective masses without the aid of the see-saw mechanism, provides an interesting alternative to the standard leptogenesis picture. Here we review the theory and phenomenology of Dirac leptogenesis and show that it is a viable theory capable of simultaneously satisfying all relevant bounds from cosmology, neutrino physics, and flavor violation. In addition, we also explore several potential extensions of the model, such as the possibility of right-handed sneutrino dark matter and the potential for relating the leptogenesis mechanism to the origin of the mu-term. Theories with a heavy gravitino and gaugino masses generated by anomaly mediation emerge as one natural context for Dirac leptogenesis. In such models the lightest neutralino is often expected to be predominately wino or Higgsino, and is a viable dark matter candidate. We conclude with an examination of the prospects for detecting the effectively monoenergetic photon signal that results from the annihilation of such a dark matter particle in the galactic halo.