Miracle-dz/UniFAR-FTUs huggingface dataset:
Coseismic Folding During Ramp Failure at the Front of the Sulaiman Fold‐and‐Thrust Belt

The Sulaiman Fold Thrust (SFT) in Central Pakistan formed during the India‐Eurasia collision in the late Cenozoic. However, the mechanics of shortening of the brittle crust at time scales of seismic cycles is still poorly understood. Here, we use radar interferometry to analyze the deformation associated with the 2015 magnitude (Mw) 5.7 Dajal blind earthquake at the eastern boundary of the SFT. We use kinematic inversions to determine the distribution of slip on the frontal ramp and of flexural slip along active axial surfaces for the forward‐ and backward‐verging two end‐member models: a double fault‐bend‐fold system and a fault‐propagation‐fold. In both models, a décollement branches into a shallow ramp at approximately 7.5 km depth with coseismic folding in the hanging wall. The Dajal earthquake ruptured the base of the Boundary Thrust buried under the sediment from the Indus‐River floodplain, representing fault‐bend or fault‐propagation folding some 30 km off its nearest surface exposure.
The Optical Gravitational Lensing Experiment. BVI Maps of Dense Stellar Regions. II. The Large Magellanic Cloud

We present three color, BVI maps of the Small Magellanic Cloud. The maps contain precise photometric and astrometric data for about 2.2 million stars from the central regions of the SMC bar covering ~2.4 square degrees on the sky. Mean brightness of stars is derived from observations collected in the course of the OGLE-II microlensing search from about 130, 30 and 15 measurements in the I, V and B-bands, respectively. Accuracy of the zero points of photometry is about 0.01 mag, and astrometry 0.15 arcsec (with possible systematic error up to 0.7 arcsec). Color-magnitude diagrams of observed fields are also presented. The maps of the SMC are the first from the series of similar maps covering other OGLE fields: LMC, Galactic bulge and Galactic disk. The data are very well suited for many projects, particularly for the SMC which has been neglected photometrically for years. Because of potentially great impact on many astrophysical fields we decided to make the SMC data available to the astronomical community from the OGLE Internet archive.
Spectroscopic confirmation of the low-latitude object FSR 1716 as an old globular cluster

Star clusters are invaluable tracers of the Galactic components and the discovery and characterization of low-mass stellar systems can be used to appraise their prevailing disruption mechanisms and time scales. However, owing to the significant foreground contamination, high extinction, and still uncharted interfaces of the underlying Milky Way components, objects at low Galactic latitudes are notoriously difficult to characterize. Here, we present the first spectroscopic campaign to identify the chemodynamical properties of the low-latitude star cluster FSR 1716. While its photometric age and distance are far from settled, the presence of RR Lyrae variables indicates a rather old cluster variety. Using medium-resolution (R$\sim$10600) calcium triplet (CaT) spectroscopy obtained with the wide-field multi-fibre AAOmega instrument, we identified six member candidates with a mean velocity of $-30$ km s$^{-1}$ and a velocity dispersion of 2.5$\pm$0.9 km s$^{-1}$. The latter value implies a dynamic mass of $\sim$1.3$\times$10$^4$ M$_{\odot}$, typical of a low-mass globular cluster. Combined with our derived CaT metallicity of $-1.38\pm0.20$ dex, this object is finally confirmed as an old, metal-poor globular cluster.
Endothelial Cell Activation and Thrombin Generation Assessment for the Risk of Severe Early Onset Preeclampsia. the ROADMAP-EOP Study

Background The ROADMAP-EOP study aimed to identify clinically relevant biomarkers of hypercoagulability for the identification of pregnant women at risk of early onset preeclampsia worsening. Methods The ROADMAP-EOP observational single center retrospective case–control study was conducted in Greece (Centre for Human Reproduction, Genesis Athens Clinic, Athens, Greece) from July 2020 to July and enrolled pregnant women diagnosed with EOP stratified in mild EOP group (n = 34) and severe EOP group (n = 15) as well as women with uncomplicated pregnancy (control group; n = 35). All women were assessed with thromboelastometry (ROTEM®), Calibrated Automated Thrombogram®, tissue factor activity (TFa), procoagulant phospholipid dependentclotting time (Procoag-PPL®), Proteins S (PS), TFPI, D-dimer, antithrombin (AT), thrombomodulin (TM), fibrinogen, prothrombin time (PT) and activated partial thromboplastin time (aPTT). The primary study end-point was severe earlyonset preeclampsia. Principal component analysis (PCA) was performed. Results The PCA analysis showed that a score composed of the lag-time, ttPeak and Procoag-PPL accurately predicted severe EOP (sensitivity 71.4%, specificity 61.8%, and AUC of the ROC analysis 0.953). Conclusion The pilot ROADMAP-EOP shows that activation of endothelial cells and blood hypercoagulability are driven events in the worsening of EOP. Among a large panel of biomarkers and coagulation assays, thrombingeneration test and procoagulant phospholipid dependent clotting time emerged as clinically relevant for the evaluation of the risk of severe EOP. This methodology for the development of a new clinic-biological risk assessment model for prompt identification of pregnant women at risk of severe EOP must be validated in a large multi-centerprospective study.
Robust State‐and‐Disturbance Observer Design for Linear Non‐minimum‐phase Systems

When there are external disturbances acting on the system, the conventional Luenberger observer design for state estimation usually results in a biased state estimate. This paper presents a robust state and disturbance observer design that gives both accurate state and disturbance estimates in the face of large disturbances. The proposed robust observer is structurally different from the conventional one in the sense that a disturbance estimation term is included in the observer equation. With this disturbance estimation term, the robust observer design problem is skillfully transformed into a disturbance rejection control problem. We then can utilize the standard H∞ control design tools to optimize the robust observer between the disturbance rejection ability and noise immune ability. An important advantage of the proposed robust observer is that it applies to both minimum‐phase systems and non‐minimum phase systems.
No enhancement of the localization length for two interacting particles in a random potential

We study two interacting particles in a random potential chain by means of the transfer matrix method. The dependence of the two-particle localization length ${\ensuremath{\lambda}}_{2}$ on disorder and interaction strength is investigated. Our results demonstrate that the recently proposed enhancement of ${\ensuremath{\lambda}}_{2}$ as compared to the results for single particles is entirely due to the finite size of the systems considered. This is shown for a Hubbard-like on site interaction and also a long-range interaction.
A new recipe for causal completions

We discuss the asymptotic structure of spacetimes, presenting a new construction of ideal points at infinity and introducing useful topologies on the completed space. Our construction is based on structures introduced by Geroch, Kronheimer and Penrose and has much in common with the modifications introduced by Budic and Sachs as well as those introduced by Szabados. However, these earlier constructions defined ideal points as equivalence classes of certain past and future sets, effectively defining the completed space as a quotient. Our approach is fundamentally different as it identifies ideal points directly as appropriate pairs consisting of a (perhaps empty) future set and a (perhaps empty) past set. These future and past sets are just the future and past of the ideal point within the original spacetime. This provides our construction with useful causal properties and leads to more satisfactory results in a number of examples. We are also able to endow the completion with a topology. In fact, we introduce two topologies, which illustrate different features of the causal approach. In both topologies, the completion is the original spacetime together with endpoints for all timelike curves. We explore this procedure in several examples, and in particular for plane wave solutions, with satisfactory results.
Methylglyoxal-Modified Human Serum Albumin Binds to Leukocyte Myeloperoxidase and Inhibits its Enzymatic Activity

Hyperglycemia in diabetes mellitus induces modification of proteins by glucose and its derivative methylglyoxal (MG). Neutrophils perform their bactericidal activity mainly via reactive halogen (RHS) and oxygen (ROS) species generation catalyzed by myeloperoxidase (MPO) stored in neutrophil azurophilic granules (AGs) and membrane NADPH oxidase, respectively. Herein, we study the binding of human serum albumin (HSA) modified with MG (HSA-MG) to MPO and its effects on MPO activity and release by neutrophils. Peroxidase activity of MPO was registered by oxidation of 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt, and chlorinating activity by decolorization of Celestine blue B dye. Binding of HSA-MG to MPO was studied by affinity chromatography, disc-electrophoresis, ligand Western blotting and enzyme-linked solid phase immunoassay using monoclonal antibodies (mAbs) to MPO. ROS and RHS generation were detected by lucigenin (Luc) and luminol (Lum) chemiluminescence (CL), respectively. Neutrophil degranulation was assessed by flow cytometry using fluorescent labeled antibodies to the marker proteins CD63 from AGs and CD11b from peroxidase-negative granules (PNGs). NETosis was assayed by quantifying DNA network-like structures (NET-like structures) in blood smears stained by Romanowsky. HSA-MG bound to MPO, giving a stable complex (Kd = 1.5 nM) and competing with mAbs, and non-competitively inhibited peroxidase and chlorinating MPO activity and induced degranulation of PNGs but not of AGs. HSA-MG enhanced Luc-CL per se or following PMA, unlike Lum-CL, and did not affect spontaneous or PMA-stimulated NETosis. Thus, HSA modified under hyperglycemia-like conditions stimulated NADPH oxidase of neutrophils but dampened their functions dependent on activity of MPO, with no effect on its release via degranulation or NETosis. This phenomenon could underlie the downregulation of bactericidal activity of MPO and neutrophils, and hence of innate immunity, giving rise to wound healing impairment and susceptibility to infection in patients with hyperglycemia.
Polar fields for AB Doradus

Polar spots are often observed on rapidly-rotating cool stars, but the nature of the magnetic field in these spots is as yet unknown. While Zeeman‐Doppler imaging can provide surface magnetic field maps over much of the observed stellar surface, the Zeeman signature is suppressed in the dark polar regions. We have determined the effect on the global coronal structure of three current models for this polar field: that it is composed (a) of unipolar field, (b) of bipolar regions or (c) of nested rings of opposite polarity. We take as an example the young, rapid rotator AB Doradus (P rot = 0.514 d). By adding these model polar fields into the surface field maps determined from Zeeman‐Doppler imaging, we have compared the resulting coronal structure with the observable properties of the corona ‐ the magnitude and rotational modulation of the X-ray emission measure and the presence of slingshot prominences trapped in the corona around the Keplerian corotation radius. We find that only the presence of a unipolar spot has any significant effect on the overall coronal structure, forcing much of the polar field to be
A High-Sensitivity Large-Dynamic-Range Current-Domain Continuous-Time Zoom ADC for Current-Sensing Front-End

Ultrahigh sensitivity and large-dynamic-range (DR) current-sensing front-ends (CSFEs) are required in emerging biomedical applications like next-generation gene-sequencers (NGGSs). In this article, an fA-level-sensitivity and 115-dB-DR current-domain (CD) continuous-time (CT) Zoom ADC-based CSFE is presented. Three main techniques are proposed, including: 1) a novel resistive-DAC (RDAC) with ultralow noise and a compact area to achieve an fA-level sensitivity; 2) a CD CT SAR ADC serves as a coarse quantizer to extend the DR to be over 115 dB; and 3) a digital compensation scheme overcomes the offset problem of the big parasitic capacitor at the input node. Fabricated in a 180-nm CMOS process, this chip only occupies an active area of 0.182 mm2 and consumes <inline-formula> <tex-math notation="LaTeX">$77 \mu \text{W}$ </tex-math></inline-formula> at a 2-V supply voltage. At a 100-Hz bandwidth (BW), it achieves the power efficiency of 389 nJ per conversion and a resolution Figure-of-Merit (FoM<inline-formula> <tex-math notation="LaTeX">$_{\text {res}}$ </tex-math></inline-formula>) of 0.13 pA<inline-formula> <tex-math notation="LaTeX">$^{{2}}\mu \text{J}$ </tex-math></inline-formula>.
N = 1 and nonsupersymmetric open string theories in six and four space-time dimensions

This thesis contains an introductory chapter on orbifolds. The following chapter explains the foundations of orientifolds. Chapters 4-7 present own research. In chapter 4 we quantize open strings with linear boundary conditions, as they show up in electro-magnetic fields. We quantize the zero-modes for toroidal compactifications, too. As an application we calculate the commutator of the coordinate fields in the case of general constant Neveu-Schwarz U(1)-field strengths. Thereby we confirm previous results on non-commutativity of open string theories in Neveu-Schwarz backgrounds. Chapter 5 reviews the results of a former publication [1] on asymmetric orientifolds, supplemented by some recent insights in connection with chapter 4. Chapter 6 summarizes publication [2] where we investigated to what extend one can build phenomenologically interesting models from toroidal orientifolds. By turning on magnetic fluxes on D9-branes we induce chiral fermions. Most calculations are performed in an (equivalent) T-dual picture. Here the number of chiral fermions is given by the topological intersection number of D-branes. In orientifolds of toroidal compactifications one obtains either non-chiral or non-supersymmetric orientifold solutions. However both properties can be reconciled in orientifolds that are obtained from specific supersymmetric orbifold compactifications. In chapter 7 we present the ``sigma Omega'' -Orientifold on a T^6/Z(4) orbifold. As a very attractive example we investigate a supersymmetric U(4) x U(2)^3_L x U(2)^3_R model that is broken to an MSSM-like model by switching on suitable background fields in the LEEA. This chapter is based on our publication [3]. An appendix is supplemented with formulas applied in the text, as well as proofs to two theorems.
Preparation of Fluorescent Carbon Dots Composites and Their Potential Applications in Biomedicine and Drug Delivery—A Review

Carbon dots (CDs), a new member of carbon nanostructures, rely on surface modification and functionalization for their good fluorescence phosphorescence and excellent physical and chemical properties, including small size (<10 nm), high chemical stability, biocompatibility, non-toxicity, low cost, and easy synthesis. In the field of medical research on cancer (IARC), CDs, a new material with unique optical properties as a photosensitizer, are being applied to heating local apoptosis induction of cancer cells. In addition, imaging tools can also be combined with a drug to form the nanometer complex compound, the imaging guidance for multi-function dosage, so as to improve the efficiency of drug delivery, which also plays a big role in genetic diagnosis. This paper mainly includes three parts: The first part briefly introduces the synthesis and preparation of carbon dots, and summarizes the advantages and disadvantages of different preparation methods; The second part introduces the preparation methods of carbon dot composites. Finally, the application status of carbon dot composites in biomedicine, cancer theranostics, drug delivery, electrochemistry, and photocatalysis is summarized.
An Optimized Methodology for Patient-Specific Therapeutic Activity Administration in Liver Radioembolization

Radioembolization (RE) with glass microspheres (MS) loaded with Yttrium-90 (90Y) has been used to treat tumors in the liver with some reported success. However, assessing absorbed doses (AD) in the planning tumor volume (PTV) and normal liver volume (NLV) is a key problem to address in RE. In clinical practice, the computation of 90Y activity to be administered follows the manufacturer’s recommendations, which do not consider the specific characteristics of MS deposition in each patient’s liver. Our main aim is to develop a methodology to estimate the optimal activity for each patient treatment. It uses the absorbed dose distribution (ADD) derived from the Technetium-99m (99mTc)-labeled macroaggregated albumin (MAA) obtained from pre-treatment planning single-photon emission computed tomography (SPECT) images. Post-treatment positron emission tomography (PET) images of the 90Y-MS distribution were used to estimate the ADD for treatment verification. Sixteen RE treatments were retrospectively selected. The agreement between the estimated mean AD based on the planning imaging and real post-treatment mean AD was good in PTV with an intraclass correlation coefficient (ICC) of 0.79 and excellent in NLV (ICC = 0.97). The optimization of 90Y activity using pre-defined clinical AD thresholds (<70 Gy in NLV and >80 Gy in PTV) imposed on the PTV and NLV voxels showed remarkably high agreement (ICC = 0.96, p < 0.001) in eleven out of the sixteen RE treatments between SPECT-MAA-based and PET-MS-based optimal activity estimates. In conclusion, under well-controlled conditions, pre-treatment SPECT-MAA imaging predicts well the treatment of ADD. In addition, SPECT-MAA imaging can be used to optimize the 90Y-MS activity to be administered to the liver.
Holography using pixelated spatial light modulators—Part 2: applications

Abstract. Dynamic holography can replace or enhance traditional basic optical functionalities within a lot of different optical systems. In particular, the possibility of considerably changing the function of a system is an important strength that is rarely possible in conventional optical systems. Today, different spatial light modulators can be employed in order to achieve dynamic holography, but most often liquid crystal on silicon phase modulators are used. We give an overview of applications for the usage of pixelated spatial light modulators in dynamic holography based on the functionalities that the dynamic holograms fulfill.
Sensitivity Analysis of Grain Surface Chemistry to Binding Energies of Ice Species

Advanced telescopes, such as ALMA and the James Webb Space Telescope, are likely to show that the chemical universe may be even more complex than currently observed, requiring astrochemical modelers to improve their models to account for the impact of new data. However, essential input information for gas−grain models, such as binding energies of molecules to the surface, have been derived experimentally only for a handful of species, leaving hundreds of species with highly uncertain estimates. We present in this paper a systematic study of the effect of uncertainties in the binding energies on an astrochemical two-phase model of a dark molecular cloud, using the rate equations approach. A list of recommended binding energy values based on a literature search of published data is presented. Thousands of simulations of dark cloud models were run, and in each simulation a value for the binding energy of hundreds of species was randomly chosen from a normal distribution. Our results show that the binding energy of H2 is critical for the surface chemistry. For high binding energies, H2 freezes out on the grain forming an H2 ice. This is not physically realistic, and we suggest a change in the rate equations. The abundance ranges found are in reasonable agreement with astronomical ice observations. Pearson correlation coefficients revealed that the binding energy of HCO, HNO, CH2, and C correlate most strongly with the abundance of dominant ice species. Finally, the formation route of complex organic molecules was found to be sensitive to the branching ratios of H2CO hydrogenation.
UBVRI photopolarimetry of the long-period eclipsing AM Herculis binary V1309 Ori

We report simultaneous UBV RI photo-polarimetric observations of the long period (7.98 h) AM Her binary V1309 Ori. The length and shape of the eclipse ingress and egress varies from night to night. We suggest this is due to the variation in the brightness of the accretion stream. By comparing the phases of circular polarization zero-crossovers with previous observations, we confirm that V1309 Ori is well synchronized, and find an upper limit of 0.002 percent for the difference between the spin and orbital periods. We model the polarimetry data using a model consisting of two cyclotron emission regions at almost diametrically opposite locations, and centered at colatitude β = 35 ◦ and β = 145 ◦ on the surface of the white dwarf. We also present archive X-ray observations which show that the negatively polarised accretion region is X-ray bright.
Effective thermal conductivity of two-phase functionally graded particulate composites

A multiscale modeling method is proposed to derive effective thermal conductivity in two-phase graded particulate composites. In the particle-matrix zone, a graded representative volume element is constructed to represent the random microstructure at the neighborhood of a material point. At the steady state, the particle’s averaged heat flux is solved by integrating the pairwise thermal interactions from all other particles. The homogenized heat flux and temperature gradient are further derived, through which the effective thermal conductivity of the graded medium is calculated. In the transition zone, a transition function is introduced to make the homogenized thermal fields continuous and differentiable. By means of temperature boundary conditions, the temperature profile in the gradation direction is solved. When the material gradient is zero, the proposed model can also predict the effective thermal conductivity of uniform composites with the particle interactions. Parametric analyses and comparisons .
The AGN fraction-velocity dispersion relation in clusters of galaxies

Context. Some previous investigations have found that the fraction (f AGN ) of active galactic nuclei (AGNs) is lower in clusters than in the field. This can result from the suppression of galaxy-galaxy mergers in high-velocity dispersion (σ v ) clusters, if the formation and/or fueling of AGNs is directly related to the merging process. Aims. We investigate the existence of a relation between f AGN and σ v , in galaxy clusters in order to shed light on the formation and evolution processes of AGNs and cluster galaxies. Methods. Using data from the Sloan Digital Sky Survey we determine f AGN and σ v for the clusters in two samples, extracted from the catalogs of Popesso et al. (2006a, A&A, in press) and Miller et al. (2005, AJ, 130, 968), and excluding clusters with significant evidence for substructures. Results. We find a significant f AGN -σ v , anti-correlation. Clusters with σ v lower and, respectively, higher than 500 km s -1 have AGN fractions of 0.21±0.01 and 0.15±0.01, on average. The f AGN -σ v relation can be described by a model that assumes f AGN is proportional to the galaxies merging rate, plus a constant. Conclusions. Since f AGN increases with decreasing σ v , AGNs are likely to have played a significant role in heating the intra-cluster medium and driving galaxy evolution in cluster precursors and groups.