Miracle-dz/UniFAR-FTUs huggingface dataset:
Advantages and drawbacks of Thiol-ene based resins for 3D-printing

The technology of 3D printing is conquering the world and awakens the interest of many users in the most varying of applications. New formulation approaches for photo-sensitive thiol-ene resins in combination with various printing technologies, like stereolithography (SLA), projection based printing/digital light processing (DLP) or two-photon polymerization (TPP) are presented. Thiol-ene polymerizations are known for its fast and quantitative reaction and to form highly homogeneous polymer networks. As the resins are locally and temporally photo-curable the polymerization type is very promising for 3D-printing. By using suitable wavelengths, photoinitiator-free fabrication is feasible for single- and two photon induced polymerization. In this paper divinyl ethers of polyethylene glycols in combination with star-shaped tetrathiols were used to design a simple test-system for photo-curable thiol-ene resins. In order to control and improve curing depth and lateral resolution in 3D-polymerization processes, either additives in chemical formulation or process parameters can be changed. The achieved curing depth and resolution limits depend on the applied fabrication method. While two-/multiphoton induced lithography offers the possibility of micron- to sub-micron resolution it lacks in built-up speed. Hence single-photon polymerization is a fast alternative with optimization potential in sub-10-micron resolution. Absorber- and initiator free compositions were developed in order to avoid aging, yellowing and toxicity of resulting products. They can be cured with UV-laser radiation below 300 nm. The development at Fraunhofer ILT is focusing on new applications in the field of medical products and implants, technical products with respect to mechanical properties or optical properties of 3D-printed objects. Recent process results with model system (polyethylene glycol divinylether/ Pentaerithrytol tetrakis (3-mercaptopropionat), Raman measurements of polymer conversion and surface modifications using bifunctional crosslinkers are presented with advantages, drawbacks and a general outlook.
Experience of COVID-19 disease and fear of the SARS-CoV-2 virus among Polish students

Background The SARS-CoV-2 virus pandemic has significantly affected individuals and entire societies. It has caused a number of adverse consequences for public health. It has contributed to lower average life expectancy and significantly reduced the sense of health security. It has affected not only physical but also mental health. COVID-19 infections have become so common in many countries, including Poland, that almost every member of society has either experienced it themselves or has a family member or friend who have been affected by the disease. The investigations undertaken in the article concern the fear of COVID-19 infection among Polish university students, determined by the experience of the disease –whether direct or among loved ones. Methods An online survey was conducted with 851 students. It took place between 1 and 15 March 2021, a year after detection of the first case of infection with the virus in Poland. The aim of the study was to find out about the relationship between the experience of COVID-19 disease (whether direct or among people close to the respondent) and fear of this disease among university students in Poland. The analysis used intergroup comparison tests (Mann–Whitney U Test and t-test). Results The results indicate that the level of fear of COVID-19 among Polish university students was low (M = 1.98; SD = .49), with women (M = 2.04; SD = .75) presenting statistically higher (t (620.46) = 3.05; p = . 002) fear than men (M = 1.87; SD = .74). The situation of the respondent having had a close person fall ill with COVID-19 or die as a result of coronavirus infection was found to be significant for the level of experienced fear of COVID-19 in the studied group (t (469.46) = −2.98; p = . 003). Conclusions The significantly higher level of fear in the group of young people who knew someone close with severe (fatal) COVID-19 disease indicates that psychological support may be more significant for such people than for individuals who have not experienced such a situation. A similar conclusion can be formulated taking into account the gender criterion, as the results make it possible to predict that women expect more support in a pandemic situation.
SCALE SENSITIVITY IN THE MULTIPLICATIVE AHP AND SMART

We consider first a variant of the analytic hierarchy process (AHP) with a one-parametric class of geometric scales to quantify human comparative judgement and with a multiplicative structure: logarithmic regression to calculate the impact scores of the alternatives at the first evaluation level and a geometric-mean aggregation rule to calculate the final scores at the second level. We demonstrate that the rank order of the impact scores and final scores is scale-independent. Finally we show that the multiplicative AHP is an exponential version of the simple multi-attribute rating technique (SMART). In fact, the multiplicative AHP is concerned with ratios of intervals on the dimension of desirability, whereas SMART analyses differences in the corresponding orders of magnitude.
Diet and habit explain head‐shape convergences in natricine snakes

The concept of ecomorphs, whereby species with similar ecologies have similar phenotypes regardless of their phylogenetic relatedness, is often central to discussions regarding the relationship between ecology and phenotype. However, some aspects of the concept have been questioned, and sometimes species have been grouped as ecomorphs based on phenotypic similarity without demonstrating ecological similarity. Within snakes, similar head shapes have convergently evolved in species living in comparable environments and/or with similar diets. Therefore, ecomorphs could exist in some snake lineages, but this assertion has rarely been tested for a wide‐ranging group within a single framework. Natricine snakes (Natricinae) are ecomorphologically diverse and currently distributed in Asia, Africa, Europe and north‐central America. They are primarily semiaquatic or ground‐dwelling terrestrial snakes, but some are aquatic, burrowing or aquatic and burrowing in habit and may be generalist or specialist in diet. Thus, natricines present an interesting system to test whether snakes from different major habit categories represent ecomorphs. We quantify morphological similarity and disparity in head shape among 191 of the ca. 250 currently recognized natricine species and apply phylogenetic comparative methods to test for convergence. Natricine head shape is largely correlated with habit, but in some burrowers is better explained by dietary specialism. Convergence in head shape is especially strong for aquatic burrowing, semiaquatic and terrestrial ecomorphs and less strong for aquatic and burrowing ecomorphs. The ecomorph concept is useful for understanding natricine diversity and evolution, though would benefit from further refinement, especially for aquatic and burrowing taxa.
Increased All-cause Mortality in People With HIV and Comorbidities: Hepatitis B and C Virus Seropositivity and Hyperglycemia in Myanmar, 2005–2017

Abstract Background Hepatitis C virus (HCV) and hepatitis B virus (HBV) coinfection are associated with increased mortality in people with HIV (PWH), and hyperglycemia is a common comorbidity in PWH. In this study, we used routinely collected clinical data to assess the associations between HBV and HCV seropositivity with all-cause mortality and whether this relationship differs by hyperglycemia status. Methods Eligible participants included adult PWH (≥15 years) who initiated antiretroviral therapy between May 2005 and June 2016 in Myanmar. HBV and HCV serostatus and hyperglycemia were measured at enrollment to HIV care using HBV surface antigen, HCV antibody tests, and random blood glucose (≥140 mg/dL), respectively. Results Among 27 722 PWH, 2260 (8%) were HBV seropositive, 2265 (9%) were HCV seropositive, 178 (0.6%) were HBV-HCV seropositive, and 1425 (5%) had hyperglycemia. During the median follow-up (interquartile range) of 3.1 (1.5–5.1) years, 3655 (13%) PWH died, and the overall mortality rate was 3.8 (95% CI, 3.7–3.9) per 100-person-years (PY). The mortality rate (per 100 PY) among PWH who were HBV seropositive was 4.6, among PWH who were HCV seropositive it was 5.1, and among PWH who were HBV-HCV seropositive it was 7.1. When stratified by glycemic status, the mortality rate was higher among patients with hyperglycemia compared with those with euglycemia (5.4 vs 4.0 per 100 PY), and the difference in mortality rate between patients with hyperglycemia and euglycemia was highest among those with HCV seropositivity (9.8 vs 5.0 per 100 PY). Conclusions Increased mortality rates associated with HBV and HCV seropositivity in PWH differed by their glycemic status. PWH with HCV seropositivity and hyperglycemia had the highest mortality rates.
Testing the niche reduction hypothesis for a fossorial rodent (Geomys bursarius) experiencing agricultural intensification

Abstract Habitat loss and fragmentation from conversion to agriculture are known threats to grassland species. However, continued agricultural intensification may further reduce a species distribution and realized niche. Here, we create species distribution models (SDMs) for the plains pocket gopher (Geomys bursarius), an ecosystem engineer in grasslands, for historic and contemporary eras in a dynamic agroecosystem and test the “niche reduction hypothesis. ” We compare SDMs created from gopher occurrences from the historic era (~1950s, pre‐agricultural intensification) and the contemporary era (post‐agricultural intensification) and assess model transferability. We evaluate shifts in environmental relationships, changes in limiting factors, and an overall decline in niche hypervolume. SDMs were nontransferable between the historic and contemporary eras. Environmental drivers of gopher distribution shifted from elevation, precipitation, and land cover in the 1950s to land cover, soil texture, and soil drainage presently. There also were shifts in environmental associations with gophers now occurring at lower elevations, in sandier soils, and less often in agriculture. Dominant limiting factors of gophers shifted from precipitation to land cover. Gophers were not detected at historic locations during recent resurveys. Contemporary niche hypervolume was reduced compared with the historic niche hypervolume. We found support for the niche reduction hypothesis for a fossorial, grassland species. Further application of the niche reduction hypothesis in landscapes experiencing agricultural intensification is warranted. Understanding niche reduction allows for conservation efforts that promote continued persistence in the contemporary niche while also identifying areas to restore within the historic niche.
Alternative expressions for energies and forces due to angle bending and torsional energy

We have derived alternative expressions for computing the energies and forces associated with angle bending and torsional energy terms commonly used in molecular mechanics and molecular dynamics computer programs. Our expressions address the problems of singularities that are intrinsic in popular angle energy functions and that occur from other chain rule derivations of force expressions. Most chain rule derivations of expressions for Cartesian forces due to angle energies make use of relations such as \documentclass{article}\pagestyle{empty}\begin{document}$$ \frac{{\partial E}}{{\partial x}} = \frac{{\partial E}}{{\partial \phi }}\frac{{\partial \phi }}{{\partial \cos \phi }}\frac{{\partial \cos \phi }}{{\partial x}} $$\end{document} where ϕ is a bond or torsion angle, E(ϕ) is energy, and ∂/∂x represents a derivative with respect to some Cartesian coordinate. This expression leads to singularities from the middle term, −1/sin ϕ, when ϕ is 0 or π. This is a problem that prevents the use of torsional energy expressions that have phase angles, ϕ°, other than 0 or π, such as in E(ϕ) = κ[1 + cos(nϕ − phsi;°)]. Our derivations make use of a different, but equivalent, form of the chain rule: \documentclass{article}\pagestyle{empty}\begin{document}$$ \frac{{\partial E}}{{\partial x}} = \frac{{\partial E}}{{\partial \phi }}\frac{{\partial \phi }}{{\partial x}} $$\end{document} This form still possesses singularities for the bond angle forces since the last factor is undefined when ϕ is 0 or π. However, the alternate form may be used to great advantage for the torsional angle forces where no such problem arises. The new expressions are necessary if one desires the use of torsional energy expressions with general phase angles. Even for energy expressions in common use, i.e., with phase angles of 0 or π, our force expressions are as computationally efficient as the standard ones. The new expressions are applicable to all molecular simulations that employ restrained, or phase‐shifted, torsional angle energy expressions.
Variability of human brain and muscle optical pathlength in different experimental conditions

Pathlength can be evaluated by measuring the time taken from a picosecond (psec) near infrared (IR) laser pulse to cross tissue. Differential pathlength factor (DPF) is calculated by dividing the mean pathlength by the inter-fiber distance. Data on DPF variability on humans are scarce. We investigated the forehead and forearm DPF in resting conditions and dynamically during brain hypoxic hypoxia, muscle ischemia and voluntary isometric exercise. At 3 cm inter optode spacing DPF at 800 nm was 4.3 +/- 0.2 (n equals 14, mean +/- SD) on the forearm, and 6.5 +/- 0.5 (n equals 8) on the forehead. Brain, muscle, and breast DPF values were almost constant over the inter optode spacing 2.5 - 4 cm. DPF was roughly constant in the central region of forehead. DPF drastically decreased under the fronto- temporal junction for the presence of muscle in the optical field. DPF decreased 5 - 10% during forearm ischemia with and without maximal voluntary contraction and during brain hypoxic hypoxia.
Fermat's principle, caustics, and the classification of gravitational lens images

A scalar description of gravitational lensing based on Fermat's principle is described. The lensing mass is assumed to be confined to a single plane between the source and the observer, and a time delay is associated with each position in the sky of a potential image. The extrema of this time surface then give the true positions of the images. A topological classification of image configurations is presented, and the results are generalized to cases of three and five-image lensing geometries. A computer-graphical approach to the study of lensing by model galaxies and clusters is described, and the design of a simple optical apparatus which could be used for fast modelling of image geometries is outlined. The connection between the Fermat approach and the classical theory of caustics and the more recent general theory of catastrophies is developed. The extension of the results to multiple scattering is considered. 42 references.
Quantification of plasma produced OH and electron fluxes at the liquid anode and their role in plasma driven solution electrochemistry

Plasma–liquid interactions enable various applications through the generation of a large range of reactive species in solution. In this work, we report on the interaction of a pulsed atmospheric pressure glow-like discharge with a liquid anode. Particularly, the flux of hydroxyl (OH) radicals and electrons in the plasma at the liquid anode are measured by laser induced fluorescence (LIF) spectroscopy and current measurements to investigate the role of OH and electrons in plasma-enabled redox chemistry in solution. The impact of the voltage pulse width, voltage amplitude, liquid temperature and conductivity on the OH density distribution was also investigated. We observed a significant OH density near the liquid surface, which showed a transition from a ring-shaped structure to a more uniform structure with increasing plasma power. This transition coincided with a similar transition in the plasma emission intensity and electron density profile. A Raman laser scattering study indicated that this transition can be attributed to an enhanced N2 mixing at larger plasma-dissipated powers. Besides, a time resolved measurement showed that the OH density segregates radially in the afterglow at velocities exceeding the gas velocity at room temperature due to enhanced gas convection resulting from the plasma-induced gas heating. While the OH flux was of the order of ∼1021 m−2 s−1, approximately two orders of magnitude lower than the electron flux, significant reduction in the solution occurs during the voltage pulse. Nonetheless, a slow oxidation was observed in the afterglow due to the much longer lifetime of OH radicals compared to electrons. The Faradaic efficiency of the liquid redox chemistry was evaluated with H cell measurements and showed a good agreement with a 1D liquid phase model with the measured electron and OH fluxes as the input. This result shows the capability to quantitatively describe the plasma-driven solution electrochemistry for a model redox couple based on OH and electron driven reactions.
Cognitive Function Trajectories and Factors among Chinese Older Adults with Subjective Memory Decline: CHARLS Longitudinal Study Results (2011–2018)

Older adults with subjective cognitive decline are at increased risk of future pathological cognitive decline and dementia. Subjective memory decline is an early sign of cognitive decline; preventing or slowing cognitive decline in at-risk populations remains an elusive issue. This study aimed to examine the cognitive trajectories and factors in older adults with subjective memory decline. Latent growth curve models (LGCMs) were fitted to examine the cognitive function trajectories and factors among 1465 older adults (aged 60+ years) with subjective memory decline. Data were obtained from four waves from the China Health and Retirement Longitudinal Study (CHARLS, 2011–2018), which is a large nationally representative sample of the Chinese population. The results showed that older adults with better initial cognition had a slower decline rate, which may be accelerated by advanced age, low-level education, a rapid decrease in instrumental activities of daily living (IADL) ability, and rapid increase in depression levels. This study was the first to examine the trajectories of cognitive function and its factors in a high-risk population with subjective memory decline. These findings may guide prevention approaches to tackle the issues of cognitive function decline and dementia.
Split-step methods for numerical modeling of synchronously pumped crystalline Raman laser

Raman lasers based on stimulated Raman scattering are attractive sources of laser radiation in a visible and an infrared spectral range. Synchronously pumped crystalline Raman lasers present interesting possibility to obtain effective generation in picosecond or femtosecond time-scale. According to semiclassical theory, their dynamic process can be described by a system of partial differential equations for optical and phonons fields. In the case of picosecond or femtosecond regime the set of equations has to be solved numerically. This is especially valid for synchronous pumping. The formal form of formulas is very similar to the task of optical parametrical process. The optical parametrical process is described by coupling of three optical waves. In the case of stimulated Raman scattering coupling is between the two optical fields and phonon field. Otherwise, the sets of equations are analogous. For this reason, the behavior is the same and the output properties of synchronously pumped Raman lasers have similar characteristics as a synchronously pumped optical parametrical oscillator. In this contribution, the split-step methods for numerical solution of synchronously pumped crystalline Raman lasers are presented and compared. In addition, the fundamental behavior of these systems is described.
Knowledge Atlas of Insular Epilepsy: A Bibliometric Analysis

Objective In order to determine research hotspots and prospective directions, this work used VOSviewer and CiteSpace to assess the current state of insular epilepsy research. Methods We looked for pertinent research about insular epilepsy published between the first of January 2000 and the thirtieth of April 2022 in the Web of Science Core Collection (WoSCC) database. CiteSpace and VOSviewer were used to build a knowledge atlas by analyzing authors, institutions, countries, keywords with citation bursts, keyword clustering, keyword co-occurrence, publishing journals, reference co-citation patterns, and other factors. Results A total of 305 publications on insular epilepsy were found. Nguyen DK had the most articles published (37), whereas Mauguière F and Isnard J had the highest average number of citations/publications (39.37 and 38.09, respectively). The leading countries and institutions in this field were the United States (82 papers) and Université de Montréal (40 papers). Authors, countries, and institutions appear to be actively collaborating. Hot topics and research frontiers included surgical treatment, functional network connectivity, and the application of neuroimaging methods to study insular epilepsy. Conclusion In summary, the most influential articles, authors, journals, organizations, and countries on the subject of insular epilepsy were determined by this analysis. This study investigated the area of insular epilepsy research and forecasted upcoming trends using co-occurrence and evolution methods.
Barriers and facilitators to nurse practitioner buprenorphine prescribing for opioid use disorder in primary care settings

Supplemental Digital Content is Available in the Text. ABSTRACT Background: Increasing access to opioid use disorder (OUD) treatment is critical to curbing the opioid epidemic, particularly for rural residents who experience numerous health and health care disparities, including higher overdose death rates and limited OUD treatment access compared with urban dwellers. Buprenorphine–naloxone is an evidence-based treatment for OUD that is well suited for rural areas. However, providers must have a specialized federal waiver to prescribe the medication. Despite the acceleration of the opioid epidemic in rural areas and the recent liberalization of federal buprenorphine–naloxone prescribing laws, few providers hold buprenorphine–naloxone prescribing waivers and even fewer prescribe the medication. Purpose: This study explores barriers and facilitators to buprenorphine–naloxone prescribing among nurse practitioners (NPs) working in primary care settings in eastern North Carolina. Methodology: Individual interviews were conducted with 13 NPs working in primary care settings in eastern North Carolina. Qualitative thematic analysis was used to identify perceived barriers and facilitators to buprenorphine–naloxone prescribing. Results: Analysis found prescribing barriers related to OUD stigma, perceived knowledge, federal and state regulation, and prescribing resources and found facilitators related to adopting a person-centered approach, developing prescriber skills, and access to prescribing resources. Conclusions: The barriers and facilitators that NPs experience related to buprenorphine prescribing for OUD are similar to those faced by physicians, although the barriers arguably more profound. Future research should consider how to mitigate these prescribing barriers to facilitate NP buprenorphine prescribing for OUD. Implications: To our knowledge, this is the first qualitative study of NP buprenorphine–naloxone prescribing in rural areas. Given the prominence of OUD in rural regions and the key role NPs play in primary care provision, this study lays import groundwork for developing interventions to support buprenorphine–naloxone prescribing by NPs practicing in rural regions.