Miracle-dz/UniFAR-FTUs huggingface dataset:
Causality violation and naked time machines in AdS5

We study supersymmetric charged rotating black holes in AdS5, and show that closed timelike curves occur outside the event horizon. Also upon lifting to rotating D3 brane solutions of type-IIB supergravity in ten dimensions, closed timelike curves are still present. We believe that these causal anomalies correspond to loss of unitarity in the dual = 4, D = 4 super Yang-Mills theory, i.e. the chronology protection conjecture in the AdS bulk is related to unitarity bounds in the boundary CFT. We show that no charged or uncharged geodesic can penetrate the horizon, so that the exterior region is geodesically complete. These results still hold true in the quantum case, i. e. the total absorption cross section for Klein-Gordon scalars propagating in the black hole background is zero. This suggests that the effective temperature is zero instead of assuming the naively found imaginary value.
Diplejía facial como forma de presentación del síndrome de Guillain Barré

Introduction: the bilateral facial palsy is a rare symptom in medical practice, it represents between 0.6 and 1.6% of various series of facial paralysis. The facial nerve can be frequently affected in Guillain-Barre syndrome, but unilaterally. It is unusual for its initial presentation to observe a bilateral facial paralysis, without other neurological focus. Case report: a 54-year old male patient, attending to the emergency room at Abel Santamaria Cuadrado General University Hospital with a bilateral facial paralysis without other neurological signs, which symptoms appeared 6 days after the beginning of the diplegia. The atypical presentation of Guillain-Barre syndrome with its onset of facial diplegia before taking the remaining peripheral nerves is rare; it stressed the importance of the clinical suspicion together with the laboratory findings; as a result the patient can benefit from a prompt treatment. Discussion: the case described that peripheral polyneuropathy symptoms appeared six days after the onset of bilateral facial weakness. Generally facial diplegia appears after the motor symptoms of Guillain-Barre syndrome or associated with the phase of osteotendinous hyporeflexia .
On Faster and fair lookup operation in content-addressable networks

Lookup operations in CAN might take a long time, as requests are passed only to direct neighbors. Realities ease this problem, but their random nature does not ensure fairness between participating nodes. In this paper we propose multiple levels of long range neighbors, called Reference Points (RPs), placed in a deterministic manner. Their location is calculated for each node so as to ensure reaching any point in the coordinate space in a comparably small number of steps. Multi-level RPs also bring fairness to CAN.
It's about time: confronting latency in the development of groupware systems

The presence of network latency leads to usability problems in distributed groupware applications. Example problems include difficulty synchronizing tightly-coupled collaboration, jarring changes in the user interface following the repair of conflicting operations, and confusion when participants discuss state that appears differently to each of them. Techniques exist that can help mitigate the effects of latency, both in the user interface and the groupware application. However, as these techniques necessitate the manipulation of state over time, the effort required to implement them can be significant. In this paper, we present timelines, a programming model allowing the explicit treatment of time in groupware applications. The model has been implemented as part of the Janus toolkit.
Co-Processed Chitin-Mannitol as a New Excipient for Oro-Dispersible Tablets

This study describes the preparation, characterization and performance of a novel excipient for use in oro-dispersible tablets (ODT). The excipient (Cop–CM) consists of chitin and mannitol. The excipient with optimal physicochemical properties was obtained at a chitin: mannitol ratio of 2:8 (w/w) and produced by roll compaction (RC). Differential scanning calorimetry (DSC), Fourier transform-Infrared (FT-IR), X-ray powder diffraction (XRPD) and scanning electron microscope (SEM) techniques were used to characterize Cop–CM, in addition to characterization of its powder and ODT dosage form. The effect of particle size distribution of Cop–CM was investigated and found to have no significant influence on the overall tablet physical properties. The compressibility parameter (a) for Cop–CM was calculated from a Kawakita plot and found to be higher (0.661) than that of mannitol (0.576) due to the presence of the highly compressible chitin (0.818). Montelukast sodium and domperidone ODTs produced, using Cop–CM, displayed excellent physicochemical properties. The exceptional binding, fast wetting and superdisintegration properties of Cop–CM, in comparison with commercially available co-processed ODT excipients, results in a unique multifunctional base which can successfully be used in the formulation of oro-dispersible and fast immediate release tablets.
Naloxone Reversal of Buprenorphine-induced Respiratory Depression

Background:The objective of this investigation was to examine the ability of the opioid antagonist naloxone to reverse respiratory depression produced by the &mgr;-opioid analgesic, buprenorphine, in healthy volunteers. The studies were designed in light of the claims that buprenorphine is relatively resistant to the effects of naloxone. Methods:In a first attempt, the effect of an intravenous bolus dose of 0.8 mg naloxone was assessed on 0.2 mg buprenorphine–induced respiratory depression. Next, the effect of increasing naloxone doses (0.5–7 mg, given over 30 min) on 0.2 mg buprenorphine–induced respiratory depression was tested. Subsequently, continuous naloxone infusions were applied to reverse respiratory depression from 0.2 and 0.4 mg buprenorphine. All doses are per 70 kg. Respiration was measured against a background of constant increased end-tidal carbon dioxide concentration. Results:An intravenous naloxone dose of 0.8 mg had no effect on respiratory depression from buprenorphine. Increasing doses of naloxone given over 30 min produced full reversal of buprenorphine effect in the dose range of 2–4 mg naloxone. Further increasing the naloxone dose (doses of 5 mg or greater) caused a decline in reversal activity. Naloxone bolus doses of 2–3 mg, followed by a continuous infusion of 4 mg/h, caused full reversal within 40–60 min of both 0.2 and 0.4 mg buprenorphine–induced respiratory depression. Conclusions:Reversal of buprenorphine effect is possible but depends on the buprenorphine dose and the correct naloxone dose window. Because respiratory depression from buprenorphine may outlast the effects of naloxone boluses or short infusions, a continuous infusion of naloxone may be required to maintain reversal of respiratory depression.
Near‐Term Travel Speed Prediction Utilizing Hilbert–Huang Transform

Abstract: Accurate short‐term prediction of travel speed as a proxy for time is central to many Intelligent Transportation Systems, especially for Advanced Traveler Information Systems and Advanced Traffic Management Systems. In this study, we propose an innovative methodology for such prediction. Because of the inherently direct derivation of travel time from speed data, the study was limited to the use of speed only as a single predictor. The proposed method is a hybrid one that combines the use of the empirical mode decomposition (EMD) and a multilayer feedforward neural network with backpropagation. The EMD is the key part of the Hilbert–Huang transform, which is a newly developed method at NASA for the analysis of nonstationary, nonlinear time series. The rationale for using the EMD is that because of the highly nonlinear and nonstationary nature of link speed series, by decomposing the time series into its basic components, more accurate forecasts would be obtained. We demonstrated the effectiveness of the proposed method by applying it to real‐life loop detector data obtained from I‐66 in Fairfax, Virginia. The prediction performance of the proposed method was found to be superior to previous forecasting techniques. Rigorous testing of the distribution of prediction errors revealed that the model produced unbiased predictions of speeds. The superiority of the proposed model was also verified during peak periods, midday, and night. In general, the method was accurate, computationally efficient, easy to implement in a field environment, and applicable to forecasting other traffic parameters.
The Promoting Effect of the Extracellular Matrix Peptide TNIIIA2 Derived from Tenascin-C in Colon Cancer Cell Infiltration

The extracellular matrix (ECM) molecule tenascin C (TNC) is known to be highly expressed under various pathological conditions such as inflammation and cancer. It has been reported that the expression of TNC is correlated with the malignant potential of cancer. In our laboratory, it was found that the peptide derived from the alternative splicing domain A2 in TNC, termed TNIIIA2, has been shown to influence a variety of cellular processes, such as survival, proliferation, migration, and differentiation. In this study, we investigated the effect of TNC/TNIIIA2 on the invasion and metastasis of colon cancer cells, Colon26-M3.1, or PMF-Ko14, using an in vitro and in vivo experimental system. The degree of cell invasion was increased by the addition of TNC and TNIIIA2 in a dose-dependent manner. The invasion by TNC and TNIIIA2 were suppressed by an MMP inhibitor or TNIIIA2-blocking antibody. In an in vivo experiment, pulmonary metastasis was promoted conspicuously by the addition of TNIIIA2. In this study, we found that colon cancer cell invasion and metastasis was accelerated by TNC/TNIIIA2 via MMP induction. This result suggests the possibility of a new strategy targeting TNC/TNIIIA2 for colon cancer.
Literature Survey of Association Rule Based Techniques for Preserving Privacy

The paper gives an overview of privacy preserving in association rule mining techniques. In this paper, all the present privacy preserving using association rule hiding techniques are discussed. This paper also proposes a classification hierarchy that sets the basis for analyzing the work which has been performed in this context. A detailed review of the work accomplished in this area is also given, along with the coordinates of each work to the classification hierarchy.
CB1 Cannabinoid Receptors and On-Demand Defense Against Excitotoxicity

Abnormally high spiking activity can damage neurons. Signaling systems to protect neurons from the consequences of abnormal discharge activity have been postulated. We generated conditional mutant mice that lack expression of the cannabinoid receptor type 1 in principal forebrain neurons but not in adjacent inhibitory interneurons. In mutant mice,the excitotoxin kainic acid (KA) induced excessive seizures in vivo. The threshold to KA-induced neuronal excitation in vitro was severely reduced in hippocampal pyramidal neurons of mutants. KA administration rapidly raised hippocampal levels of anandamide and induced protective mechanisms in wild-type principal hippocampal neurons. These protective mechanisms could not be triggered in mutant mice. The endogenous cannabinoid system thus provides on-demand protection against acute excitotoxicity in central nervous system neurons.
University of Groningen Molecular adaptations in human atrial fibrillation Brundel

Background: Atrial fibrillation (AF) is accompanied by electrical, structural and ion-channel protein remodeling. We tested whether calcium activated neutral protease, calpain, is involved in AF-induced remodeling. Therefore, calpain activity and localization in atrial tissue of patients with paroxysmal and persistent AF were determined, and correlated with remodeling processes. Methods and Results: Right atrial appendages were obtained from patients with paroxysmal (n=7, PAF), persistent (n=10, CAF) lone AF and controls in sinus rhythm (n=10) and used for measuring tissue calpain activity with a fluorogenic calpain specific substrate. Calpain I localization was studied by immunohistochemistry. Ion-channel protein expression was determined by slot-blot analysis. Structural changes were quantified by counting atrial myocytes showing degeneration or hibernation. Rate adaptation was calculated from atrial effective refractory periods (AERPs) at 5 basic cycle lengths. Tissue calpain activity was significantly increased in PAF (2-fold, p<0.001) and CAF (3-fold, p<0.001), mainly due to calpain I activation. Calpain I was localized in the cytosol, intercalated discs and nucleus of cardiomyocytes. Patients with AF showed
Physiologically Realistic and Validated Mathematical Liver Model Revels Hepatobiliary Transfer Rates for Gd-EOB-DTPA Using Human DCE-MRI Data

Objectives Diffuse liver disease (DLD), such as non-alcoholic fatty liver disease (NASH) and cirrhosis, is a rapidly growing problem throughout the Westernized world. Magnetic resonance imaging (MRI), based on uptake of the hepatocyte-specific contrast agent (CA) Gd-EOB-DTPA, is a promising non-invasive approach for diagnosing DLD. However, to fully utilize the potential of such dynamic measurements for clinical or research purposes, more advanced methods for data analysis are required. Methods A mathematical model that can be used for such data-analysis was developed. Data was obtained from healthy human subjects using a clinical protocol with high spatial resolution. The model is based on ordinary differential equations and goes beyond local diffusion modeling, taking into account the complete system accessible to the CA. Results The presented model can describe the data accurately, which was confirmed using chi-square statistics. Furthermore, the model is minimal and identifiable, meaning that all parameters were determined with small degree of uncertainty. The model was also validated using independent data. Conclusions We have developed a novel approach for determining previously undescribed physiological hepatic parameters in humans, associated with CA transport across the liver. The method has a potential for assessing regional liver function in clinical examinations of patients that are suffering of DLD and compromised hepatic function.
Value of cardiac troponin I cutoff concentrations below the 99th percentile for clinical decision-making.

BACKGROUND The aim of this study was to evaluate factors influencing the 99th percentile for cardiac troponin I (cTnI) when this cutoff value is established on a highly sensitive assay, and to compare the value of this cutoff to that of lower cutoffs in the prognostic assessment of patients with coronary artery disease. METHODS We used the recently refined Access AccuTnI assay (Beckman-Coulter) to assess the distribution of cTnI results in a community population of elderly individuals [PIVUS (Prospective Study of the Vasculature in Uppsala Seniors) study; n = 1005]. The utility of predefined cTnI cutoffs for risk stratification was then evaluated in 952 patients from the FRISC II (FRagmin and Fast Revascularization during InStability in Coronary artery disease) study at 6 months after these patients had suffered acute coronary syndrome. RESULTS Selection of assay results from a subcohort of PIVUS participants without cardiovascular disease resulted in a decrease of the 99th percentile from 0.044 microg/L to 0.028 microg/L. Men had higher rates of cTnI elevation with respect to the tested thresholds. Whereas the 99th percentile cutoff was not found to be a useful prognostic indicator for 5-year mortality, both the 90th percentile (hazard ratio 3.1; 95% CI 1.9-5.1) and the 75th percentile (hazard ratio 2.8; 95% CI 1.7-4.7) provided useful prognostic information. Sex-specific cutoffs did not improve risk prediction. CONCLUSIONS The 99th percentile of cTnI depends highly on the characteristics of the reference population from which it is determined. This dependence on the reference population may affect the appropriateness of clinical conclusions based on this threshold. However, cTnI cutoffs below the 99th percentile seem to provide better prognostic discrimination in stabilized acute coronary syndrome patients and therefore may be preferable for risk stratification.
TNNT2 Gene Polymorphisms Are Associated with Susceptibility to Idiopathic Dilated Cardiomyopathy in the Han Chinese Population

Background. Idiopathic dilated cardiomyopathy (DCM) is characterized by ventricular chamber enlargement and systolic dysfunction. The pathogenesis of DCM remains uncertain, and the TNNT2 gene is potentially associated with DCM. To assess the role of TNNT2 in DCM, we examined 10 tagging single nucleotide polymorphisms (SNPs) in the patients. Methods. A total of 97 DCM patients and 189 control subjects were included in the study, and all SNPs were genotyped by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Results. In the TNNT2 gene, there was a significant association between DCM and genotype for the tagging SNPs rs3729547 (χ 2 = 6.63, P = 0.036, OR = 0.650, and 95% CI = 0.453–0.934) and rs3729843 (χ 2 = 9.787, P = 0.008, OR = 1.912, and 95% CI = 1.265–2.890) in the Chinese Han population. Linkage disequilibrium (LD) analysis showed that the SNPs rs7521796, rs2275862, rs3729547, rs10800775, and rs1892028, which are approximately 6 kb apart, were in high LD (D′ > 0.80) in the DCM patients. Conclusion. These results suggest that the TNNT2 polymorphisms might play an important role in susceptibility to DCM in the Chinese Han population.
The P3 Parietal-To-Frontal Shift Relates to Age-Related Slowing in a Selective Attention Task

Older adults recruit relatively more frontal as compared to parietal resources in a variety of cognitive and perceptual tasks. It is not yet clear whether this parietal-to-frontal shift is a compensatory mechanism, or simply reflects a reduction in processing efficiency. In this study we aimed to investigate how the parietal-to-frontal shift with aging relates to selective attention. Fourteen young and 26 older healthy adults performed a color Flanker task under three conditions (incongruent, congruent, neutral) and event-related potentials (ERPs) were measured. The P3 was analyzed for the electrode positions Pz, Cz, and Fz as an indicator of the parietal-to-frontal shift. Further, behavioral performance and other ERP components (P1 and N1 at electrodes O1 and O2; N2 at electrodes Fz and Cz) were investigated. First young and older adults were compared. Older adults had longer response times, reduced accuracy, longer P3 latencies, and a more frontal distribution of P3 than young adults. These results confirm the parietal-to-frontal shift in the P3 with age for the selective attention task. Second, based on the differences between frontal and parietal P3 activity the group of older adults was subdivided into those showing a rather equal distribution of the P3 and older participants showing a strong frontal focus of the P3. Older adults with a more frontally distributed P3 had longer response times than participants with a more equally distributed P3. These results suggest that the frontally distributed P3 observed in older adults has no compensatory function in selective attention but rather indicates less efficient processing and slowing with age.
IGHV1-69 B Cell Chronic Lymphocytic Leukemia Antibodies Cross-React with HIV-1 and Hepatitis C Virus Antigens as Well as Intestinal Commensal Bacteria

B-cell chronic lymphocytic leukemia (B-CLL) patients expressing unmutated immunoglobulin heavy variable regions (IGHVs) use the IGHV1-69 B cell receptor (BCR) in 25% of cases. Since HIV-1 envelope gp41 antibodies also frequently use IGHV1-69 gene segments, we hypothesized that IGHV1-69 B-CLL precursors may contribute to the gp41 B cell response during HIV-1 infection. To test this hypothesis, we rescued 5 IGHV1-69 unmutated antibodies as heterohybridoma IgM paraproteins and as recombinant IgG1 antibodies from B-CLL patients, determined their antigenic specificities and analyzed BCR sequences. IGHV1-69 B-CLL antibodies were enriched for reactivity with HIV-1 envelope gp41, influenza, hepatitis C virus E2 protein and intestinal commensal bacteria. These IGHV1-69 B-CLL antibodies preferentially used IGHD3 and IGHJ6 gene segments and had long heavy chain complementary determining region 3s (HCDR3s) (≥21 aa). IGHV1-69 B-CLL BCRs exhibited a phenylalanine at position 54 (F54) of the HCDR2 as do rare HIV-1 gp41 and influenza hemagglutinin stem neutralizing antibodies, while IGHV1-69 gp41 antibodies induced by HIV-1 infection predominantly used leucine (L54) allelic variants. These results demonstrate that the B-CLL cell population is an expansion of members of the innate polyreactive B cell repertoire with reactivity to a number of infectious agent antigens including intestinal commensal bacteria. The B-CLL IGHV1-69 B cell usage of F54 allelic variants strongly suggests that IGHV1-69 B-CLL gp41 antibodies derive from a restricted B cell pool that also produces rare HIV-1 gp41 and influenza hemagglutinin stem antibodies.
Functions of microtubules in the Saccharomyces cerevisiae cell cycle

We used the inhibitor nocodazole in conjunction with immunofluorescence and electron microscopy to investigate microtubule function in the yeast cell cycle. Under appropriate conditions, this drug produced a rapid and essentially complete disassembly of cytoplasmic and intranuclear microtubules, accompanied by a rapid and essentially complete block of cellular and nuclear division. These effects were similar to, but more profound than, the effects of the related drug methyl benzimidazole carbamate (MBC). In the nocodazole-treated cells, the selection of nonrandom budding sites, the formation of chitin rings and rings of 10-nm filaments at those sites, bud emergence, differential bud enlargement, and apical bud growth appeared to proceed normally, and the intracellular distribution of actin was not detectably perturbed. Thus, the cytoplasmic microtubules are apparently not essential for the establishment of cell polarity and the localization of cell-surface growth. In contrast, nocodazole profoundly affected the behavior of the nucleus. Although spindle-pole bodies (SPBs) could duplicate in the absence of microtubules, SPB separation was blocked. Moreover, complete spindles present at the beginning of drug treatment appeared to collapse, drawing the opposed SPBs and associated nuclear envelope close together. Nuclei did not migrate to the mother-bud necks in nocodazole-treated cells, although nuclei that had reached the necks before drug treatment remained there. Moreover, the double SPBs in arrested cells were often not oriented toward the budding sites, in contrast to the situation in normal cells. Thus, microtubules (cytoplasmic, intranuclear, or both) appear to be necessary for the migration and proper orientation of the nucleus, as well as for SPB separation, spindle function, and nuclear division.