Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of prewarming and/or delayed light activation on resin-modified glass ionomer bond strength to tooth structures.

INTRODUCTION Recent research shows that the acid-base reaction and light-activated polymerization in resin-modified glass ionomers (RMGI) compete with and inhibit one another. In addition, extrinsic energy would improve some properties of RMGI. This in vitro study evaluated the effect of prewarming and/or delayed light activation on bond strength of RMGI to tooth structure. MATERIALS AND METHODS Ninety-six flat enamel and dentin surfaces of human molars were ground with sequentially finer abrasives to 600-grit silicon carbide paper. Each surface was treated with a cavity conditioner for 10 seconds, rinsed, and gently air-dried (n=12). RMGI was applied to tooth substrates according to the following protocols: group 1) according to manufacturer's instructions; group 2) a delay of two minutes in light activation; group 3) prewarming of the encapsulated material (90 seconds, 40°C); group 4) prewarming plus a delay of two minutes in light activation. After 24 hours of storage at 37°C and 500 rounds of thermocycling, the samples were tested for shear bond strength and analyzed using two-way analysis of variance and Tukey HSD test (α=0.05). RESULTS Significant differences were observed between study groups (p<0.05). The highest enamel bond strength was recorded in group 2. Regarding dentin groups, the highest bond strength was recorded in group 1. CONCLUSION Within the limitations of the present study, delaying light activation might improve bond strength of RMGI to enamel; however, the standard procedure recommended by the manufacturer is the best procedure for bonding of RMGI to dentin. More investigations are necessary.
Characterization of ciliary muscle relaxation induced by various agents in cats.

PURPOSE To understand the cellular mechanism underlying the relaxation of ciliary muscle, relaxation induced by prostaglandins (PGs) and some other agents was characterized in the cat. METHODS Tone of isolated ciliary muscle was measured by means of a force-displacement transducer. Adenylate cyclase activity was determined with membrane fraction of ciliary muscle by measuring the formation of cyclic adenosine monophosphate (cAMP). RESULTS The addition of various PGs and isoproterenol relaxed the ciliary muscle that had been precontracted with 3 x 10(-6) M carbachol. The relaxation was dose dependent, with an EC50 of 2 x 10(-7) M for PGE2. The rank order of potency by which PGs induced relaxation (PGE2 = E1 > D2 > F2 alpha > I2) was identical with that reported for EP type prostaglandin receptor-mediated responses except for PGD2, which was more potent than expected. Agents that increased cellular cAMP, such as forskolin and IBMX, also relaxed the precontracted muscle. Nitric oxide donors, such as sodium nitroprusside and S-nitroso-N-acetyl-DL-penicillamine (SNAP), also caused dose-dependent relaxation. PGs and isoproterenol, but not nitroprusside, stimulated adenylate cyclase. The rank order of potency by which PGs stimulate adenylate cyclase was similar to that observed for muscle relaxation, suggesting that cAMP is the cellular second messenger for the PG-induced muscle relaxation and thus that PG receptors of EP2 and DP type are involved. CONCLUSIONS Relaxation of cat ciliary muscle is mediated by two independent mechanisms: a cAMP-dependent one, which includes beta-adrenergic, EP2, and DP receptor-mediated responses, and a cAMP-independent one, which includes the nitric oxide-induced mechanism.
In vitro activation of transcription by the human T-cell leukemia virus type I Tax protein

The human T-cell leukemia virus type I (HTLV-I) regulatory protein Tax activates transcription of the proviral long terminal repeats and a number of cellular promoters. We have developed an in vitro system to characterize the mechanism by which Tax interacts with the host cell transcription machinery. Tax was purified from cells infected with a baculovirus expression vector. Addition of these Tax preparations to nuclear extracts from uninfected human T lymphocytes activated transcription of the HTLV-I long terminal repeat approximately 10-fold. Transcription-stimulatory activity copurified with the immunoreactive 40-kDa Tax polypeptide on gel filtration chromatography, and, as expected, the effect of recombinant Tax was diminished in HTLV-I-infected T-lymphocyte extracts containing endogenous Tax. Tax-mediated transactivation in vivo has been previously shown to require 21-bp-repeat Tax-responsive elements (TxREs) in the promoter DNA. Stimulation of transcription in vitro was also strongly dependent on these sequences. To investigate the mechanism of Tax transactivation, cellular proteins that bind the 21-bp-repeat TxREs were prepared by DNA affinity chromatography. Recombinant Tax markedly increased the formation of a specific host protein-DNA complex detected in an electrophoretic mobility shift assay. These data suggest that Tax activates transcription through a direct interaction with cellular proteins that bind to the 21-bp-repeat TxREs.
Modeling Trait Anxiety: From Computational Processes to Personality

Computational methods are increasingly being applied to the study of psychiatric disorders. Often, this involves fitting models to the behavior of individuals with subclinical character traits that are known vulnerability factors for the development of psychiatric conditions. Anxiety disorders can be examined with reference to the behavior of individuals high in “trait” anxiety, which is a known vulnerability factor for the development of anxiety and mood disorders. However, it is not clear how this self-report measure relates to neural and behavioral processes captured by computational models. This paper reviews emerging computational approaches to the study of trait anxiety, specifying how interacting processes susceptible to analysis using computational models could drive a tendency to experience frequent anxious states and promote vulnerability to the development of clinical disorders. Existing computational studies are described in the light of this perspective and appropriate targets for future studies are discussed.
DIMRO, a DiffServ-integrated multicast algorithm for Internet resource optimization in source specific multicast applications

In this work DIMRO, an efficient algorithm to build source specific multicast trees, is presented. DIMRO aims at achieving a high traffic balance in the network in order to avoid bandwidth bottlenecks and consequent network partitions, one of the main causes for low network performance. To do so, it computes multicast trees by dynamically selecting the least loaded available paths, obtaining an optimal distribution of network resources. Strictly integrated with the DiffServ Quality of Service (QoS) approach, the proposed multirate native multicast algorithm maps the QoS service requested by receivers into the proper DiffServ class, so as to respect the expected QoS requirements. The results are a better leverage of the network bandwidth resources, an improved QoS perceived by multicast group members, and time and resource saving due to its low computational complexity, as shown through extensive C++ based simulation campaign.
The Use of Accelerometers and Gyroscopes to Estimate Hip and Knee Angles on Gait Analysis

In this paper the performance of a sensor system, which has been developed to estimate hip and knee angles and the beginning of the gait phase, have been investigated. The sensor system consists of accelerometers and gyroscopes. A new algorithm was developed in order to avoid the error accumulation due to the gyroscopes drift and vibrations due to the ground contact at the beginning of the stance phase. The proposed algorithm have been tested and compared to some existing algorithms on over-ground walking trials with a commercial device for assisted gait. The results have shown the good accuracy of the angles estimation, also in high angle rate movement.
AGING OF MONETARY SAVING PROPOSITION FORMULATED FROM THE FIRST- AND THE THIRD-PERSON PERSPECTIVES AS A FACTOR MODULATING THE FRAMING EFFECT

The article uncovers the role of aging of monetary saving proposition in its topical mental accounting. The monetary saving propositions were formulated from the firstand the third-person perspective to investigate whether a self-other discrepancy impacts on an aging of saving proposition. Also, the absolute and relative amount of monetary saving was varied in two stages (high vs. low), and two dates of the beginning of a sell-out were applied (past and present). The discrepancy between aging of propositions formulated from the first and the third person perspectives appears to have a different impact on the high and low relative monetary savings, which seems to be almost opposite. A high relative saving proposition ages quicker than a low relative one, but only when it is formulated from the first person perspective. When a saving proposition is formulated from a third-person perspective, aging runs quicker for low relative saving, and a high relative saving proposition seems to age slower. Correspondingly, the framing effect is modulated by two factors: 1) aging of monetary saving proposition and 2) personal perspective in formulation of saving proposition.
Applied process knowledge and market performance: the moderating effect of environmental uncertainty

Challenges the idea of an unconditional and positive influence of knowledge on performance without regard to environmental uncertainty. Focuses on applied process knowledge spanning the supply chain (i.e. considers supplier, internal, and customer sources). A survey of 208 manufacturing firms found the association between applied process knowledge and firm market performance is positive and statistically significant when demand unpredictability is high (but not when low); statistically significant when product churning (uncertainty) is high (but not when low); and not moderated by core production or logistics process change. Firm size and production technology were also controlled. Firms that can determine the moderating effect of the different types of environmental uncertainty they face upon their knowledge‐performance relationship will perform better in terms of market performance indicators.
A Meta-Analysis of Direct and Mediating Effects of Community Coalitions That Implemented Science-Based Substance Abuse Prevention Interventions

This article reports results of a meta-analysis of the effects of a set of community coalitions that implemented science-based substance use prevention interventions as part of a State Incentive Grant (SIG) in Kentucky. The analysis included assessment of direct effects on prevalence of substance use among adolescents as well as assessment of what “risk” and “protective” factors mediated the coalition effects. In addition, we tested whether multiple science-based prevention interventions enhanced the effects of coalitions on youth substance use. Short-term results (using 8th-grade data) showed no significant decreases in six prevalence of substance use outcomes—and, in fact, a significant though small increase in prevalence of use of one substance (inhalants). Sustained results (using 10th-grade data), however, showed significant, though small decreases in three of six substance use outcomes—past month prevalence of cigarette use, alcohol use, and binge drinking. We found evidence that the sustained effects on these three prevalence outcomes were mediated by two posited risk factors: friends' drug use and perceived availability of drugs. Finally, we found that the number of science-based prevention interventions implemented in schools within the coalitions did not moderate the effects of the coalitions on the prevalence of drug use. Study limitations are noted.
Probing and Controlling Autoionization Dynamics with Attosecond Light Pulses in a Strong Dressing Laser Field

We review the theoretical investigations of the autoionzing wave packet excited by an isolated attosecond pulse and dressed by a time-delayed intense laser pulse. The few-level model is described and the applications in photoemission and photoabsorption are given. For the three-level, resonantly coupled system, the main features are explained by the Rabi oscillation modulated in the dressing field. For such a system, by precisely controlling the intensity and the time delay of the dressing pulse, we show the shaping of the attosecond pulse when propagating in a gas medium. A more sophisticated multi-level system with coupling terms involving continuum states is also developed, in which the importance of the continuum-continuum coupling is evaluated with the help of an ab initio calculation.
Brorin is required for neurogenesis, gliogenesis, and commissural axon guidance in the zebrafish forebrain

Bmps regulate numerous neural functions with their regulators. We previously identified Brorin, a neural-specific secreted antagonist of Bmp signaling, in humans, mice, and zebrafish. Mouse Brorin has two cysteine-rich domains containing 10 cysteine residues in its core region, and these are located in similar positions to those in the cysteine-rich domains of Chordin family members, which are secreted Bmp antagonists. Zebrafish Brorin had two cysteine-rich domains with high similarity to those of mouse Brorin. We herein examined zebrafish brorin in order to elucidate its in vivo actions. Zebrafish brorin was predominantly expressed in developing neural tissues. The overexpression of brorin led to the inactivation of Bmp signaling. On the other hand, the knockdown of brorin resulted in the activation of Bmp signaling and brorin morphants exhibited defective development of the ventral domain in the forebrain. Furthermore, the knockdown of brorin inhibited the generation of γ–aminobutyric acid (GABA)ergic interneurons and oligodendrocytes and promoted the generation of astrocytes in the forebrain. In addition, brorin was required for axon guidance in the forebrain. The present results suggest that Brorin is a secreted Bmp antagonist predominantly expressed in developing neural tissues and that it plays multiple roles in the development of the zebrafish forebrain.
Productive Infection Maintains a Dynamic Steady State of Residual Viremia in Human Immunodeficiency Virus Type 1-Infected Persons Treated with Suppressive Antiretroviral Therapy for Five Years

ABSTRACT To provide insight into the dynamics and source of residual viremia in human immunodeficiency virus (HIV) patients successfully treated with antiretroviral therapy, 14 intensely monitored patients treated with indinavir and efavirenz sustaining HIV RNA at <50 copies/ml for >5 years were studied. Abacavir was added to the regimen of eight patients at year 5. After the first 9 months of therapy, HIV RNA levels had reached a plateau (“residual viremia”) that persisted for over 5 years. Levels of residual viremia differed among patients and ranged from 3.2 to 23 HIV RNA copies/ml. Baseline HIV DNA was the only significant pretreatment predictor of residual viremia in regression models including baseline HIV RNA, CD4 count, and patient age. In the four of five patients with detectable viremia who added abacavir to their regimen after 5 years, HIV RNA levels declined rapidly. The estimated half-life of infected cells was 6.7 days. Decrease in activated memory cells and a reduction in gamma interferon production to HIV Gag and p24 antigen in ELISpot assays were observed, consistent with a decrease in HIV replication. Thus, in patients treated with efavirenz plus indinavir, levels of residual viremia were established by 9 months, were predicted by baseline proviral DNA, and remained constant for 5 years. Even after years of highly suppressive therapy, HIV RNA levels declined rapidly after the addition of abacavir, suggesting that productive infection contributes to residual ongoing viremia and can be inhibited with therapy intensification.
Omitting Axillary Surgery for Low-risk Breast Cancer Patients: A Swedish Prospective Cohort Study

The effects of mammography screening are a decrease in the sizes of tumours and a shift in stage. Very few small breast cancers (< or = 10 mm) have lymph node metastases when screening-detected, the rate being as low as 7%. Axillary clearance is not necessary for all such small tumours. A Swedish prospective cohort study, scheduled for 1500 patients, is being launched, where axillary surgery is omitted for screening-detected breast cancers of < or = 10 mm showing Elston grade I or II/and/or S-phase < or = 10%. Axillary surgery, with the associated disadvantages, will not be performed in 970 women out of 1000 expecting an axillary recurrence rate of 3%. Nordic breast cancer centres are welcome to join the study, which has already recruited around 500 patients.
Correction of Mobile TLS Intensity Data for Water Leakage Spots Detection in Metro Tunnels

Terrestrial laser scanning (TLS) can accurately and thoroughly document the actual geometrical deformations and surface conditions of metro tunnel structures using high-density point clouds. In addition, TLS can record the backscattered intensity values of each point simultaneously. Backscattered intensity values are significant measures of the spectral property of scanned objects in the near-infrared region of the electromagnetic spectrum. The intensity values of water leakage regions are theoretically lower than those of the background because of the high water absorption coefficient in the near-infrared spectrum. Thus, the intensity data can be used in water leakage detection and quantitative analysis. This letter investigates the feasibility of a new mobile system called Faro Focus3D X330 for data collection, processing, and intensity correction to detect and extract water leakage spots in metro tunnels. A case study of the Shanghai Metro was conducted. Results show that the corrected intensity value is an effective physical criterion to detect water leakages in metro tunnels. By combing the 3-D point cloud, the location, area, and even water content of the leakage regions can be accurately determined.
Manifold Learning for Human Population Structure Studies

The dimension of the population genetics data produced by next-generation sequencing platforms is extremely high. However, the “intrinsic dimensionality” of sequence data, which determines the structure of populations, is much lower. This motivates us to use locally linear embedding (LLE) which projects high dimensional genomic data into low dimensional, neighborhood preserving embedding, as a general framework for population structure and historical inference. To facilitate application of the LLE to population genetic analysis, we systematically investigate several important properties of the LLE and reveal the connection between the LLE and principal component analysis (PCA). Identifying a set of markers and genomic regions which could be used for population structure analysis will provide invaluable information for population genetics and association studies. In addition to identifying the LLE-correlated or PCA-correlated structure informative marker, we have developed a new statistic that integrates genomic information content in a genomic region for collectively studying its association with the population structure and LASSO algorithm to search such regions across the genomes. We applied the developed methodologies to a low coverage pilot dataset in the 1000 Genomes Project and a PHASE III Mexico dataset of the HapMap. We observed that 25.1%, 44.9% and 21.4% of the common variants and 89.2%, 92.4% and 75.1% of the rare variants were the LLE-correlated markers in CEU, YRI and ASI, respectively. This showed that rare variants, which are often private to specific populations, have much higher power to identify population substructure than common variants. The preliminary results demonstrated that next generation sequencing offers a rich resources and LLE provide a powerful tool for population structure analysis.
Erythrocyte folate, plasma folate and plasma homocysteine during normal pregnancy and postpartum: a longitudinal study comprising 404 Danish women

Abstract: Objective: To assess folate and homocysteine status during normal pregnancy and postpartum in a longitudinal setting. Methods: This study, performed in 1995–1996, comprised 404 healthy pregnant Danish Caucasian women residential in Copenhagen County. Women taking folic acid tablets or vitamin B12 injections were not included. Dietary multivitamin supplements containing folic acid 100 μg or vitamin B12 1 μg, taken by 34%, were discontinued at inclusion. Participants had normal renal function. Folate status [erythrocyte (Ery‐) folate, plasma (P‐) folate, P‐homocysteine] was measured at 18, 32 and 39 wk of gestation and 8 wk postpartum when the women were lactating. Results: Through 18, 32 and 39 wk of gestation and postpartum, P‐folate demonstrated a significant fall: median values were 14.4, 10.2, 9.3 and 8.9 nmol/L, respectively (P < 0.0001). The prevalence of low P‐folate <6 nmol/L increased during pregnancy from 0.7% to 19.0% postpartum (P < 0.0001). Ery‐folate displayed a similar, significant fall: median value was 0.84, 0.75, 0.65 and 0.55 μmol/L, respectively (P < 0.0001). The prevalence of low Ery‐folate <0.40 μmol/L increased during pregnancy from 0.5% to 17.2% postpartum (P < 0.0001). P‐homocysteine demonstrated a significant increase: median value was 6.4, 7.0, 7.7 and 10.8 μmol/L, respectively (P < 0.0001). The prevalence of P‐homocysteine >13 μmol/L increased during pregnancy from 0.7% to 20.8% postpartum (P < 0.0001). The prevalence of low folate status (defined as P‐folate <6 nmol/L and P‐homocysteine >13 μmol/L) was 0%, 0%, 1.2%, and 8.4% at 18, 32 and 39 wk of gestation and 8 wk postpartum, respectively. Conclusion: Low folate status occurs among Danish pregnant women, especially in late pregnancy and postpartum during lactation. Despite new guidelines for folic acid supplement since 1997, only 13% of pregnant women followed the guidelines in 2003. The official recommendations for periconceptional folic acid supplement should be reconsidered and reinforced.
The Criminal Recidivism Process

List of illustrations and tables Preface 1. Introduction: the prediction of criminal behavior 2. The study 3. Recidivists: a general profile 4. Comparisons with nonrecidivists 5. Comparisons across offender groups 6. Comparisons within offender groups 7. Final considerations References Appendix: interview form Index.
Plane-based self-calibration of radial distortion

We present an algorithm for plane-based self-calibration of cameras with radially symmetric distortions given a set of sparse feature matches in at least two views. The projection function of such cameras can be seen as a projection with a pinhole camera, followed by a non-parametric displacement of the image points in the direction of the distortion center. The displacement is a function of the points' distance to the center. Thus, the generated distortion is radially symmetric. Regular cameras, fish-eyes as well as the most popular central catadioptric devices can be described by such a model. Our approach recovers a distortion function consistent with all the views, or estimates one for each view if they are taken by different cameras. We consider a least squares algebraic solution for computing the homography between two views that is valid for rectified (undistorted) point correspondences. We observe that the terms of the function are bilinear in the unknowns of the homography and the distortion coefficient associated to each point. Our contribution is to approximate this non-convex problem by a convex one. To do so, we replace the bilinear terms by a set of new variables and obtain a linear least squares problem. We show that like the distortion coefficients, these variables are subject to monotonicity constraints. Thus, the approximate problem is a convex quadratic program. We show that solving it is sufficient for accurately estimating the distortion parameters. We validate our approach on simulated data as well as on fish-eye and catadioptric cameras. We also compare our solution to three state-of-the-art algorithms and show similar performance.