Miracle-dz/UniFAR-FTUs huggingface dataset:
Apolipoprotein E Genotype in Very Preterm Neonates with Intrauterine Growth Restriction: An Analysis of the German Neonatal Network Cohort

Aim. Cord blood of intrauterine growth restricted (IUGR) neonates displays lipid changes towards atherosclerotic profiles. Apolipoprotein E (ApoE) and its isoforms (e2, e3, and e4) are involved in the regulation of lipid metabolism. Specifically, ApoE e4 has been associated with atherosclerotic diseases, while e2 has a favorable effect. We therefore hypothesized that ApoE e4 haplotype is frequently observed in IUGR neonates and contributes to impaired fetal growth and the association of IUGR with cardiovascular and metabolic diseases later in life. Methods. A cohort of 4885 preterm infants (≥22+0 and <32+0 weeks of gestation and birth weight below 1500 g) from the GNN study cohort was analyzed. Neonates were categorized into subgroups of <3rd, 3rd–10th, and >10th birth weight percentile. Analysis of the single nucleotides rs429358 and rs7412, identifying the ApoE genotype, was carried out using TaqMan® SNP genotyping assays. The proportional odds model was used to assess data. Results. No association was found between genotype and birth weight percentiles in each of the subgroups. Conclusion. ApoE genotype and low birth weight depict two distinct risk factors for cardiovascular disease without being directly associated.
Student Cyberloafing In and Out of the Classroom in China and the Relationship with Student Performance

This study investigates the in-class and out-of-class cyberloafing activities of students in China, and tests the relationship between those activities and academic performance. A sample of 1,050 undergraduate students at a large University in China reported their in-class (N = 548) and out-of-class (N = 502) cyberloafing activities, which were tested against the students' academic performance. The test results show a negative relationship between in-class cyberloafing and academic performance, but an inverted U-shaped relationship between out-of-class cyberloafing and academic performance. The results support our propositions that cyberloafing is a harmful distraction in the classroom, but can have positive effects when performed in moderation outside the classroom as a means of effort recovery.
Vascular Remodelling in Well-controlled Hypertensive Patients: The Challenge of Residual Risk Management.

BACKGROUND Residual cardiovascular risk (RCVR) is an emerging issue in the clinical and therapeutic management of patients affected by hypertension. In fact, a number of clinical studies showed that even in case of optimal blood pressure (BP) control, the hypertensive patients still carry a sizeable increase in the CV risk as compared to normotensive individuals. METHODS We will review the clinical evidence about the determinants and the impact of RCVR on hypertension, with a specific focus on the progression of vascular damage. RESULTS The presence of RCVR in hypertensive patients is a significant phenomenon which challenges our clinical effort far beyond the reaching of BP targets. Although major determinants of RCVR are still undefined, there is a clear indication about the importance of an early and sustained control of BP values, so as to prevent the onset of target organ damage. In fact, our data and findings from the literature indicate that the "pseudo-normalization" of BP is not sufficient to abolish the risk of pro-atherogenic remodeling of arterial vessels. CONCLUSION Additional studies are needed to establish whether the intervention on specific BP profiles and inflammatory mechanisms can have some clinical relevance in the management of RCVR. In the meanwhile, the precise phenotyping of the CV risk profile of each patient, coupled with a tailored pharmacological approach, represents the most effective strategy to hinder the progression of vascular damage and reduce the RCVR.
Plasma-stimulated medium kills TRAIL-resistant human malignant cells by promoting caspase-independent cell death via membrane potential and calcium dynamics modulation

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and cold plasma-stimulated medium (PSM) have been shown to exhibit tumor-selective cytotoxicity and have emerged as promising new tools for cancer treatment. However, to date, at least to the best of our knowledge, no data are available as to which substance is more potent in killing cancer cells. Thus, in this study, we systematically compared their abilities to kill human malignant cells from different origins. We found that PSM dose-dependently killed TRAIL-resistant melanoma, osteosarcoma and neuroblastoma cells. Moreover, PSM had little cytotoxicity toward osteoblasts. PSM was more potent than TRAIL in inducing caspase-3/7 activation, mitochondrial network aberration and caspase-independent cell death. We also found that PSM was more potent in inducing plasma membrane depolarization (PMD) and disrupting endoplasmic-mitochondrial Ca2+ homeostasis. Moreover, persistent PMD was caused by different membrane-depolarizing agents; the use of the anti-type II diabetes drug, glibenclamide, alone caused mitochondrial fragmentation and enhanced TRAIL-induced Ca2+ modulation, mitochondrial network abnormalities and caspase-independent cell killing. These results demonstrate that PSM has a therapeutic advantage over TRAIL owing to its greater capacity to evoke caspase-independent cell death via mitochondrial network aberration by disrupting membrane potential and Ca2+ homeostasis. These findings may provide a strong rationale for developing PSM as a novel approach for the treatment of TRAIL-resistant malignant cells.
Neocortical Layer 6B as a Remnant of the Subplate ‐ A Morphological Comparison

Abstract The fate of the subplate (SP) is still a matter of debate. The SP and layer 6 (which is ontogenetically the oldest and innermost neocortical lamina) develop coincidentally. Yet, the function of sublamina 6B is largely unknown. It has been suggested that it consists partly of neurons from the transient SP, however, experimental evidence for this hypothesis is still missing. To obtain first insights into the neuronal complement of layer 6B in the somatosensory rat barrel cortex, we used biocytin stainings of SP neurons (aged 0‐4 postnatal days, PND) and layer 6B neurons (PND 11‐35) obtained during in vitro whole‐cell patch‐clamp recordings. Neurons were reconstructed for a quantitative characterization of their axonal and dendritic morphology. An unsupervised cluster analysis revealed that the SP and layer 6B consist of heterogeneous but comparable neuronal cell populations. Both contain 5 distinct spine‐bearing cell types whose relative fractions change with increasing age. Pyramidal cells were more prominent in layer 6B, whereas non‐pyramidal neurons were less frequent. Because of the high morphological similarity of SP and layer 6B neurons, we suggest that layer 6B consists of persistent non‐pyramidal neurons from the SP and cortical L6B pyramidal neurons.
Recent insights into mitochondrial targeting strategies in liver transplantation

Ischemia/reperfusion (I/R) injury in liver transplantation can disrupt the normal activity of mitochondria in the hepatic parenchyma. This potential dysfunction of mitochondria after I/R injury could be responsible for the initial poor graft function or primary nonfunction observed after liver transplantation. Thus, determining the mechanisms that lead to human hepatic mitochondrial dysfunction might contribute to improving the outcome of liver transplantation. Furthermore, early identification of novel prognostic factors involved in I/R injury could serve as a key endpoint to predict the outcome of liver grafts and also to promote the early adoption of novel strategies that protect against I/R injury. Here, we briefly review recent advances in the study of mitochondrial dysfunction and I/R injury, particularly in relation to liver transplantation. Next, we highlight various pharmacological therapeutic strategies that could be applied, and discuss their relationship to relevant mitochondrion-related processes and targets. Lastly, we note that although considerable progress has been made in our understanding of I/R injury and mitochondrial dysfunction, further investigation is required to elucidate the cellular and molecular mechanisms underlying these processes, thereby identifying biomarkers that can help in evaluating donor organs.
Automated Detection and Classification of Sleep Apnea Types Using Electrocardiogram (ECG) and Electroencephalogram (EEG) Features

1.1 Sleep and sleep disorders Sleep, which is defined as a passive period in organic physiology until the mid-20th century, is accepted to be an indispensable period of life cycle with today’s technological advances. While wakefulness is associated with the active excitation of Central Nervous System (CNS), sleep has been recognized as a passive period by the elimination of excitation. However, recent studies have shown that sleep is independent of wakefulness, generated by a sequence of changes in CNS, and a combination of five periods with clear boundaries. Sleep is not the disruption of daily life for a period of time or a waste of time. It is an active period which is important to renew our mental and physical health everyday and is covering one– third of our lives. Sleep activity is important for resting during the working period of basal metabolism of human body. The advances in technology enabling the measurement and quantification of brain activity make possible the micro and macro analysis of brain during both sleep and wakefulness states. With the studies investigating the CNS, it is observed the existence of some centrals causing the sleep by inhibiting the other regions of brain. As a result, sleep, which is an active and other state of consciousness, is a brain state of high coordination (Erdamar, 2007). Since breathing is established autonomously during sleep, it is affected by many anatomical and physiological parameters. Depending on this situation, various sleep disorders occur. There are more than eighty known sleeping diseases. Most of them cause person’s health to deteriorate and a decrease in life quality. As a result of the research carried out for many years, a list of sleep disorders, which are generally occurring, can be seen as in Table 1. Sleep disorders can be examined in two classes, parasomnia and dissomnia.
Permeability to moisture of synthetic resin finishes for aircraft

The permeability to moisture and some related properties of various synthetic resin finishes used on aircraft are reported. The glyceryl-phthalate enamels are less permeable to moisture under relatively dry conditions than are the enamels made with a phenol-formaldehyde resin. This order is reversed, however, under wet conditions. This corresponds with the service uses to which these finishes have been found to be best adapted. The aircraft finish made with a cellulose nitrate base is much more permeable to water vapor under both wet and dry conditions than are the resinous materials. The permeability of these finishes is not directly proportional to the vapor-pressure difference. The rate of passage of moisture per unit difference in vapor pressure increases with rising temperature. A given type of aircraft finish transmits moisture at the same rate whether in contact with liquid water or with saturated water vapor. The mechanism of penetration is, therefore, probably the same in the two cases. The film probably behaves as a typical colloidal, permeable membrane, and the water vapor is adsorbed by it and transmitted through the film by a process of chemical diffusion. Some observations on the absorption of moisture by resinous films and the effect of carnauba wax on permeability are presented. Results of measurements of the permeability to moisture of gas-cell fabrics of varying gelatin content and amount of paraffin coating are also given; CONTENTS Page
Automatically Distributing Eulerian and Hybrid Fluid Simulations in the Cloud

Distributing a simulation across many machines can drastically speed up computations and increase detail. The computing cloud provides tremendous computing resources, but weak service guarantees force programs to manage significant system complexity: nodes, networks, and storage occasionally perform poorly or fail. We describe Nimbus, a system that automatically distributes grid-based and hybrid simulations across cloud computing nodes. The main simulation loop is sequential code and launches distributed computations across many cores. The simulation on each core runs as if it is stand-alone: Nimbus automatically stitches these simulations into a single, larger one. To do this efficiently, Nimbus introduces a four-layer data model that translates between the contiguous, geometric objects used by simulation libraries and the replicated, fine-grain objects managed by its underlying cloud computing runtime. Using PhysBAM particle-level set fluid simulations, we demonstrate that Nimbus can run higher detail simulations faster, distribute simulations on up to 512 cores, and run enormous simulations (10243 cells). Nimbus automatically manages these distributed simulations, balancing load across nodes and recovering from failures. Implementations of PhysBAM water and smoke simulations as well as an open source heat-diffusion simulation show that Nimbus is general and can support complex simulations. Nimbus can be downloaded from https://nimbus.stanford. edu.
Principal component reconstruction (PCR) for cine CBCT with motion learning from 2D fluoroscopy

PURPOSE This work aims to generate cine CT images (i.e., 4D images with high-temporal resolution) based on a novel principal component reconstruction (PCR) technique with motion learning from 2D fluoroscopic training images. METHODS In the proposed PCR method, the matrix factorization is utilized as an explicit low-rank regularization of 4D images that are represented as a product of spatial principal components and temporal motion coefficients. The key hypothesis of PCR is that temporal coefficients from 4D images can be reasonably approximated by temporal coefficients learned from 2D fluoroscopic training projections. For this purpose, we can acquire fluoroscopic training projections for a few breathing periods at fixed gantry angles that are free from geometric distortion due to gantry rotation, that is, fluoroscopy-based motion learning. Such training projections can provide an effective characterization of the breathing motion. The temporal coefficients can be extracted from these training projections and used as priors for PCR, even though principal components from training projections are certainly not the same for these 4D images to be reconstructed. For this purpose, training data are synchronized with reconstruction data using identical real-time breathing position intervals for projection binning. In terms of image reconstruction, with a priori temporal coefficients, the data fidelity for PCR changes from nonlinear to linear, and consequently, the PCR method is robust and can be solved efficiently. PCR is formulated as a convex optimization problem with the sum of linear data fidelity with respect to spatial principal components and spatiotemporal total variation regularization imposed on 4D image phases. The solution algorithm of PCR is developed based on alternating direction method of multipliers. RESULTS The implementation is fully parallelized on GPU with NVIDIA CUDA toolbox and each reconstruction takes about a few minutes. The proposed PCR method is validated and compared with a state-of-art method, that is, PICCS, using both simulation and experimental data with the on-board cone-beam CT setting. The results demonstrated the feasibility of PCR for cine CBCT and significantly improved reconstruction quality of PCR from PICCS for cine CBCT. CONCLUSION With a priori estimated temporal motion coefficients using fluoroscopic training projections, the PCR method can accurately reconstruct spatial principal components, and then generate cine CT images as a product of temporal motion coefficients and spatial principal components.
Thyroid hormone receptor (TR)alpha and TRbeta expression in breast cancer.

UNLABELLED There is evidence that breast cancer patients suffer from thyroid disorders. However, the relation between thyroid receptor (TR) expression and breast cancer remains unknown so far. Therefore, the aim of this study was an immunohistochemical analysis of TR expression in breast cancer patients. MATERIALS AND METHODS The expression of the combined antibody TRalpha1 and 2 and TRalpha1 or 2 alone as well as the expression of combined TRbeta1 and 2 and TRbeta1 or 2 alone was investigated with specific monoclonal or polyclonal antibodies in 82 patients. All patients presented with a first diagnosis of sporadic breast cancer. The ABC method was used for staining and staining intensities were analyzed using the IRS score. RESULTS Both TRalpha and TRbeta were expressed in the nuclei of breast cancer cells. In 24% (28/78) of the slides TRalpha1 and 2 IRS was positive. Immunopositivity for TRalpha1 was found in 55/78 slides, for TRalpha 2 in 54/79 slides (71 and 68%, respectively). The expression of TRbeta1 and 2 showed a positive detection in 33/77 (43%) of the slides, for TRbeta1 it was 43/79 (54%), for TRbeta2 60/76 (79%). Significant correlations of the expression of TRs - especially TRalpha2 - were found with further prognostic histopathological parameters such as tumor size, axillary lymph node involvement, grading and hormone receptor status. Multivariate analysis showed a trend for TRalpha2 as an independent predictor of disease-free and overall survival. DISCUSSION Our results revealed specific alterations in the expression of TRs - especially of TRalpha2 - in breast cancer patients, suggesting it as a marker with possible prognostic validity.
Fruit and vegetable consumption and anemia among adult non-pregnant women: Ghana Demographic and Health Survey

Background Anemia is the most widely prevalent form of micronutrient deficiency that affects over a quarter of the global population. Evidence suggests that the burden of anemia is higher in the developing countries with women of reproductive age and children being the most at-risk groups. The most common causes are believed to be malnutrition and low bioavailability of micronutrients, which usually result from poor dietary habits and inadequate intake of food rich in micronutrients such as fresh fruits and vegetables. Regular consumption of F&V was shown to have protective effect against NCDs; however, evidence on this protective effect against micronutrient deficiency diseases are limited. Objectives (1) To measure the prevalence of anemia among adult non-pregnant women in Ghana, and (2) to investigate if there is any cross-sectional relationship between F&V consumption and anemia. Methods This is a cross-sectional study based on data extracted from the Ghana Demographic and Health Survey, 2008. Subjects were 4,290 non-pregnant women aged between 15 and 49 years. Hemoglobin levels were measured by HemoCue® hemoglobin-meter. Association between anemia and F&V consumption was assessed by multivariable regression methods. Results Findings indicate that well over half (57.9%) of the women were suffering from anemia of some level. The percentage of women consuming at least five servings of fruits and vegetables a day were 5.4% and 2.5% respectively. Results of multivariable analysis indicated that among urban women, consumption of <5 servings fruits/day was associated with significantly higher odds of severe [AOR = 9.27; 95% CI [5.15–16.70]] and moderate anemia [AOR = 6.63; 95% CI [4.21–10.44]], and consumption of <5 servings of vegetables/day was associated with higher odds of moderate anemia [AOR = 2.39; 95% CI [1.14–5.02]] compared with those who consumed >5 servings/day. Conclusion The findings indicate that urban women who did not maintain WHO recommended level of F&V consumption bear a significantly higher likelihood of being moderate to severely anemic.
Making Sense of Big Textual Data for Health Care: Findings from the Section on Clinical Natural Language Processing

Summary Objectives: To summarize recent research and present a selection of the best papers published in 2016 in the field of clinical Natural Language Processing (NLP). Method: A survey of the literature was performed by the two section editors of the IMIA Yearbook NLP section. Bibliographic databases were searched for papers with a focus on NLP efforts applied to clinical texts or aimed at a clinical outcome. Papers were automatically ranked and then manually reviewed based on titles and abstracts. A shortlist of candidate best papers was first selected by the section editors before being peer-reviewed by independent external reviewers. Results: The five clinical NLP best papers provide a contribution that ranges from emerging original foundational methods to transitioning solid established research results to a practical clinical setting. They offer a framework for abbreviation disambiguation and coreference resolution, a classification method to identify clinically useful sentences, an analysis of counseling conversations to improve support to patients with mental disorder and grounding of gradable adjectives. Conclusions: Clinical NLP continued to thrive in 2016, with an increasing number of contributions towards applications compared to fundamental methods. Fundamental work addresses increasingly complex problems such as lexical semantics, coreference resolution, and discourse analysis. Research results translate into freely available tools, mainly for English.
Dissecting the Potential Roles of Nigella sativa and Its Constituent Thymoquinone on the Prevention and on the Progression of Alzheimer's Disease

Several nutraceuticals have been investigated for preventing or retarding the progression of different neurodegenerative diseases, including Alzheimer's disease (AD). Because Nigella sativa (NS) and its isolated compound thymoquinone (TQ) have significant anti-oxidant and anti-inflammatory proprieties, they could represent effective neuroprotective agents. The purpose of this manuscript is to analyze and to recapitulate the results of in vitro and in vivo studies on the potential role of NS/TQ in AD's prevention and treatment. The level of evidence for each included animal study has been assessed by using a modified CAMARADES (Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies) 10-item checklist. We used MEDLINE and EMBASE databases to screen relevant articles published up to July 2017. A manual search was also performed. The database search yielded 38 studies, of which 18 were included in this manuscript. Results from these approaches suggest that NS or TQ could represent an effective strategy against AD due to the balancing of oxidative processes and the binding to specific intracellular targets. The overall effects mainly regard the prevention of hippocampal pyramidal cell loss and the increased cognitive functions.