Miracle-dz/UniFAR-FTUs huggingface dataset:
Anticonvulsant Lamotrigine Administered on Reperfusion Fails To Improve Experimental Stroke Outcomes

Background and Purpose— Recent results suggest that selective inhibitors of presynaptic neuronal ion channels can diminish glutamate release during cerebral ischemia and modulate excitotoxic cell death. The aim of the present study was to evaluate lamotrigine (LTG), an antiepileptic that inhibits presynaptic sodium and voltage-sensitive calcium channels, as a potential stroke resuscitation agent in the rat. Three dosages of LTG were examined for effect on infarction volume and sensorimotor behavioral recovery after middle cerebral artery (MCA) occlusion. Methods— Halothane-anesthetized male Wistar rats were subjected to 2 hours of MCA occlusion by the intraluminal occlusion technique. Physiological variables were controlled, and ipsilateral cortical perfusion was monitored by laser Doppler flowmetry throughout ischemia. At onset of reperfusion, rats received intravenous LTG 5, 10, or 20 mg/kg or PBS (n=9 to 11 per group) during 15 minutes. Behavioral assessment was completed at 3 and 7 days after stroke, and the brain was harvested for histology (triphenyltetrazolium chloride staining). Results— Values are mean±SE. Cortical infarction volumes were unchanged in LTG-treated animals: 14±6% of contralateral cortex at 5 mg/kg LTG, 17±7% at 10 mg/kg, and 30±6% at 20 mg/kg, versus saline-treated cohorts (12±3%;P =0.19; n=9). Caudate-putamen infarction injury was also unchanged (37±11% of contralateral caudate-putamen at 5 mg/kg LTG, 44±8% at 10 mg/kg, and 65±9% at 20 mg/kg versus saline (38±11%;P =0.18). Total infarction was not different among groups (P =0.15). Consistent with histology, behavioral outcomes were unimproved by treatment. Conclusions— Histological damage and behavioral recovery at 7 days after MCA occlusion was not altered by LTG treatment over the dosage range used in the present study.
Several modifications of aggressive packet combining scheme for wireless networks

In this paper, a few schemes are presented to improve the performance of aggressive packet combining scheme (APC). To combat error in computer / data communication networks, ARQ (Automatic Repeat Request) techniques are used. Several modifications to improve performance of ARQ are suggested by recent research and are found in literature. The important modifications are majority packet combining scheme (MjPC proposed by Wicker), packet combining scheme (PC proposed by Sindhu & Chakraborty), modified packet combining scheme(MPC proposed by Bhunia), and packet reversed packet combining(PRPC proposed by Bhunia) scheme. These modifications are appropriate for improving throughput of conventional ARQ protocols. Leung proposed an idea of APC for error control in wireless networks with basic objective of error control in uplink wireless data network. We suggest a few modifications of APC to improve its performance in terms of higher throughput, lower delay and higher error correction capability.
The Effects of Children's Migration on Elderly Kin's Health: A Counterfactual Approach (Draft: Do not cite or quote)

This research was supported by National Science Foundation grant #0422976, ―Migration and Marginalization: Social Networks, Inequality and Health in Indonesia and Bangladesh‖. Additional support came from National Institute on Aging grant R03AG19294-01A1, ―Impact of Migration on Elderly Support in Bangladesh‖, and NIA grant 5P30AG017248-02 ―University of Colorado Population Aging Center‖. The authors thank Richard Rogers, Francisca Antman, Ying Lu, and Steven Stillman for their helpful advice; Jarron Saint Onge, Kunga Lama, and Yaffa Truelove for research assistance; and Christine Peterson and the IFLS Support Team for data assistance. An earlier version of this paper was presented at the Annual Meeting of the Population Association of America in New York in March 2007.
Applications communautaires spontanées dynamiquement reconfigurables en environnement pervasif. (Spontaneous social applications dynamically reconfigurable in pervasive environment)

Depuis quelques annees, des evolutions importantes ont lieu en matiere d’infrastructures technologiques. En particulier, la democratisation des dispositifs mobiles (comme les PCs, Smartphones, Tablettes, etc.) a rendu l’information accessible par le grand public partout et a tout moment, ce qui est l’origine du concept d’informatique ubiquitaire. L’approche classique des systemes de l’informatique ubiquitaire, qui repondent aux besoins des utilisateurs independants les uns des autres, a ete bouleversee par l’introduction de la dimension sociale. Ce rapprochement est a l’origine d’une discipline naissante « le pervasive social computing » ou l’informatique socio-pervasive. Les applications socio-pervasives connaissent une veritable expansion. Ces dernieres integrent de plus en plus la notion de communaute. Le succes des applications communautaires se justifie par le but poursuivi par ces dernieres qui est de repondre aux besoins des communautes et d’offrir un ‘chez soi’ virtuel, specifique a la communaute, dans lequel elle va construire sa propre identite et realiser ses objectifs. Par ailleurs, la notion de communaute represente une source d’informations contextuelles sociales. Elle est, aujourd’hui, au cœur des problematiques de personnalisation et d’adaptation des applications informatiques. Dans le cadre de cette these, nous etudions sous differents aspects les applications informatiques centrees communautes existantes et soulignons un certain nombre de carences au niveau meme de la notion de communaute, des modeles de communautes, ou encore des architectures dediees a ces applications communautaires, etc. Pour remedier a ces defauts, nous proposons trois principales contributions : Un nouveau type de communaute adapte aux exigences des environnements pervasifs qui vient rompre avec les traditionnelles communautes perennes thematiques : des communautes ephemeres, geolocalisees et spontanees (sans contrainte thematique). Un modele de communaute base sur les standards du web semantique pour repondre aux problemes lies a l’heterogeneite de conception des communautes. Une architecture dynamiquement reconfigurable pour promouvoir les communautes spontanees en aidant les utilisateurs nomades a integrer des communautes environnantes et a decouvrir les services dedies. Nous montrons la faisabilite de nos propositions pour la conception et le developpement d’applications communautaires spontanees grâce au prototype Taldea. Enfin, nous testons les approches proposees de decouverte de communaute et de services a travers plusieurs scenarios caracterises par la mobilite et l’ubiquite.
Gene networks from DNA microarray data: centrality and lethality

We construct a gene network based on expression data from DNA microarray experiments, by establishing a link between two genes whenever the Pearson's correlation coefficient between their expression profiles is higher than a certain cutoff. The resulting connectivity distribution is compatible with a power-law decay with exponent ~1, corrected by an exponential cutoff at large connectivity. The biological relevance of such network is demonstrated by showing that there is a strong statistical correlation between high connectivity number and lethality: in close analogy to what happens for protein interaction networks, essential genes are strongly overerpresented among the hubs of the network, that is the genes connected to many other genes.
The Research Using Self-Organizing Maps on Enterprise Economic Data

In this paper, firstly, it introduces the importance of integration system in enterprise economic management and gives the classification model of integration system on enterprise economic data after analyzing the importance of the classification of enterprise economic data. Secondly, the method of Self-Organizing Maps (SOM) is put forward to economic data classification and the field sets are chosen that are based on the enterprise economic data and the classification of enterprise economic data is got using the method of SOM. Finally, the conclusions are given.
Epigenetics and Colorectal Cancer Pathogenesis

Colorectal cancer (CRC) develops through a multistage process that results from the progressive accumulation of genetic mutations, and frequently as a result of mutations in the Wnt signaling pathway. However, it has become evident over the past two decades that epigenetic alterations of the chromatin, particularly the chromatin components in the promoter regions of tumor suppressors and oncogenes, play key roles in CRC pathogenesis. Epigenetic regulation is organized at multiple levels, involving primarily DNA methylation and selective histone modifications in cancer cells. Assessment of the CRC epigenome has revealed that virtually all CRCs have aberrantly methylated genes and that the average CRC methylome has thousands of abnormally methylated genes. Although relatively less is known about the patterns of specific histone modifications in CRC, selective histone modifications and resultant chromatin conformation have been shown to act, in concert with DNA methylation, to regulate gene expression to mediate CRC pathogenesis. Moreover, it is now clear that not only DNA methylation but also histone modifications are reversible processes. The increased understanding of epigenetic regulation of gene expression in the context of CRC pathogenesis has led to development of epigenetic biomarkers for CRC diagnosis and epigenetic drugs for CRC therapy.
Boundary regularity for fully nonlinear integro-differential equations

We study fine boundary regularity properties of solutions to fully nonlinear elliptic integro-differential equations of order 2s, with s ∈ (0,1). We consider the class of nonlocal operators L∗ ⊂L 0, which consists of all the infinitesimal generators of stable Levy processes belonging to the class L0 of Caffarelli-Silvestre. For fully nonlinear operators I elliptic with respec tt oL∗ ,w e prove that solutions to Iu = f in Ω, u = 0 in R n \ Ω, satisfy u/d s ∈ C s−ϵ (Ω) for all ϵ> 0, where d is the distance to ∂ Ωa ndf ∈ L ∞ . We expect the Holder exponent s − ϵ to be optimal (or almost optimal) for general right hand sides f ∈ L ∞ . Moreover, we also expect the class L∗ to be the largest scale invariant subclass of L0 for which this result is true. In this direction, we show that the class L0 is too large for all solutions to behave like d s . The constants in all the estimates in this paper remain bounded as th eo rder of the equation approaches 2.
A theoretical framework for improving the schedulability of hard and soft real-time tasks on heterogeneous network of workstations (NOWs)

This paper proposes an integrated duplication based Algorithm (IDSA) for improving the schedulability of precedence related real-time tasks with hard and soft deadlines on a set of heterogeneous network of workstations (NOWs). IDSA utilizes selective subtask duplication that enables some subtasks to have earlier start times, which results in an increased number of subtasks (and hence task sets) finishing before their deadlines, thereby increasing the Schedulability. Extensive theoretical analysis of the proposed IDSA scheme has been carried out. To that end, both the time and space complexity analysis of IDSA has been proved, in addition to its schedulability condition.
Dual task interference while walking in chronic stroke survivors

Objective: Dual-task interference is defined as decrements in performance observed when people attempt to perform two tasks concurrently, such as a verbal task and walking. The purpose of this study was to investigate the changes of gait ability according to the dual task interference in chronic stroke survivors. Design: Cross-sectional study. Methods: Ten chronic stroke survivors (9 male, 1 female; mean age, 55.30 years; mini mental state examination, 19.60; onset duration, 56.90 months) recruited from the local community participated in this study. Gait ability (velocity, paretic side step, and stride time and length) under the single- and dual-task conditions at a self-selected comfortable walking speed was measured using the motion analysis system. In the dual task conditions, subjects performed three types of cognitive tasks (controlled oral word association test, auditory clock test, and counting backwards) while walking on the track. Results: For velocity, step and stride length, there was a significant decrease in the dual-task walking condition compared to the single walking condition ( p <0.05). In particular, higher reduction of walking ability was observed when applying the counting backward task. Conclusions: Our results revealed that the addition of cognitive tasks while walking may lead to decrements of gait ability in stroke survivors. In particular, the difficulty level was the highest for the calculating task. We believe that these results provide ba-sic information for improvements in gait ability and may be useful in gait training to prevent falls after a stroke incident.
Identification of Genes Involved in Cytochrome c Biogenesis in Shewanella oneidensis, Using a Modified mariner Transposon

ABSTRACT A modified mariner transposon, miniHimar RB1, was generated to mutagenize cells of the metal-reducing bacterium Shewanella oneidensis. The use of this transposon led to the isolation of stable mutants and allowed rapid identification of disrupted genes. Fifty-eight mutants, including BG104 and BG148 with transposon insertions in the cytochrome c maturation genes ccmC and ccmF1, respectively, were analyzed. Both mutants were deficient in anaerobic respiration and cytochrome c production.
Relationship between the Local Structure of Orientation Map and the Strength of Orientation Tuning of Neurons in Monkey V1: A 2-Photon Calcium Imaging Study

A majority of neurons in the monkey primary visual cortex (V1) are tuned to stimulus orientations. Preferred orientations and tuning strengths vary among V1 neurons. The preferred orientation of neurons gradually changes across the cortex with occasional failures of this organization. How V1 neurons are arranged by the strength of orientation tuning and whether neuronal arrangement for tuning strength relates to orientation preference maps remains controversial. In this study, we performed in vivo two-photon calcium imaging in macaque V1 to examine the local spatial organization of orientation tuning at the level of single cells. We recorded fluorescence signals from individual neurons loaded with a calcium-sensitive dye in layer 2 and the uppermost tier of layer 3. The strength of orientation tuning was shared by nearby neurons, and changed across the cortex. The neurons with similar tuning strength were distributed across at least the entire thickness of layer 2. The tuning strength was weaker in regions where neurons exhibited heterogeneous preferred orientations, as compared with regions where neurons shared similar orientation preferences. Nearby direction-selective neurons often shared their preferred directions, although only a few neurons were direction selective in the layers examined. Thus, the orientation tuning strength of V1 neurons is partially predictable from the local structure of orientation map. The weaker orientation tuning we found in regions with heterogeneous orientation preferences suggests that orientation-independent interactions among local populations of V1 neurons play a critical role in determining their orientation tuning.
The StoreGate: a Data Model for the Atlas Software Architecture

The Atlas collaboration at CERN has adopted the Gaudi software architecture which belongs to the blackboard family: data objects produced by knowledge sources (e.g. reconstruction modules) are posted to a common in-memory data base from where other modules can access them and produce new data objects. The StoreGate has been designed, based on the Atlas requirements and the experience of other HENP systems such as Babar, CDF, CLEO, D0 and LHCB, to identify in a simple and efficient fashion (collections of) data objects based on their type and/or the modules which posted them to the Transient Data Store (the blackboard). The developer also has the freedom to use her preferred key class to uniquely identify a data object according to any other criterion. Besides this core functionality, the StoreGate provides the developers with a powerful interface to handle in a coherent fashion persistable references, object lifetimes, memory management and access control policy for the data objects in the Store. It also provides a Handle/Proxy mechanism to define and hide the cache fault mechanism: upon request, a missing Data Object can be transparently created and added to the Transient Store presumably retrieving it from a persistent data-base, or even reconstructing it on demand.
ADAPTIVE TIMEOUT FOR VIDEO DELIVERY OVER A BLUETOOTH WIRELESS NETWORK

Bluetooth is a short-range wireless interconnect that in its 2.0 version has sufficient capacity to support encoded video streaming, possibly from an Internet access point. The default setting of the Automatic Repeat Request (ARQ) facility leads to poor quality video, as streaming is delay-sensitive. The paper introduces an adaptive algorithm that alters the number of ARQ retransmissions according to buffer fullness, which is used to indicate both buffer congestion and radio frequency channel conditions. This is a necessary but not sufficient requirement for quality video at the receiver. In an extension to the cross-layer approach, the number of retransmissions is made sensitive to picture importance. Delivered video quality is demonstrated to be consistently high.
A closed-form capacity bound for jointly correlated MIMO channel

In this paper, a capacity bound for jointly correlated MIMO channel is investigated assuming full knowledge of the channel state information (CSI) at the receiver and statistical CSI at the transmitter. An eigenmode transmission strategy using statistical transmitter CSI is presented, and a closed-form capacity bound for eigenmode-based systems is derived. A relationship between the capacity upper bound and the permanent of the channel coupling matrix in eigenmode is established. Simulation results confirm the tightness of the obtained capacity bound.
Ju n 20 08 hep-th / yymmnnn 3-dimensional holographic trace anomaly from AdS / CFT correspondence

We explicitly obtain energy-momentum tensor at the asymptotic 3-dimensional region of Schwarzschild AdS 4 and Taub-NUT-(A)dS 4 using the so-called 'counter-term subtraction method' in Fefferman-Graham coordinate. The energy momentum tensor is presented in a closed form for the AdS 4 and for the special case of Taub-NUT-dS and in an asymptotic series for other cases. The result suggests that in light of AdS/CFT correspondence, the 3-dimensional trace anomaly can be expressed in terms of the 3-dimensional volume and Ricci scalar.
Making space for values: communication & values levers in a virtual team

The infrastructure underlying the Internet continues to evolve, with ramifications for not only the technical protocols that govern network functions, but also implications for social, economic, and legal issues. This paper uses ethnography to examine how and why ethical and social issues arise during the design of Named Data Networking, a new approach to Internet architecture. By focusing on communications modes among a distributed team of network architects, it investigates how particular modes may enable or constrain values levers: practices which encourage discussion of values during design. While face-to-face retreats encourage interdisciplinary work and subsequent discussion of moral values, mediated modes of communication tend to constrain values levers. These limitations may be overcome by encouraging communications techniques such as scenarios and demos, which can be used in both face-to-face and mediated settings.
Design of Sub-1mW Q-Enhancement CMOS LC VCO with Body-Biased Technique

A new CMOS LC Voltage Controlled Oscillator (VCO) for IEEE 802.11a application with low phase noise and consumed power less than 1mW is presented. This circuit was taped out by TSMC 0.18um 1P6M process. The measured phase noise is -115-88dBc/Hz at 1MHz offset at the operation frequency of 5.815GHz. And the dc core current consumption is 0.71mA at a supply voltage of 1.4 V. Its figure of merit (FOM) is -191dBc/Hz. Index Terms — Current Reused, Voltage Controlled Oscillator, Q-enhancement, body-biasing, low power, Sub-1mW.
Opus: University of Bath Online Publication Store Bayesian Tactile Object Recognition: Learning and Recognising Objects Using a New Inexpensive Tactile Sensor*

Bayesian tactile object recognition:learning and recognising objects using a new inexpensive tactile sensor. This version is made available in accordance with publisher policies. Please cite only the published version using the reference above. Abstract— We present a Bayesian approach to tactile object recognition that improves on state-of-the-art in using single-touch events in two ways. First by improving recognition accuracy from about 90% to about 95%, using about half the number of touches. Second by reducing the number of touches needed for training from about 200 to about 60. In addition, we use a new tactile sensor that is less than one tenth of the cost of widely available sensors. The paper describes the sensor, the likelihood function used with the Naive Bayes classifier, and experiments on a set of ten real objects. We also provide preliminary results to test our approach for its ability to generalise to previously unencountered objects.
Original Paper

Social anxiety disorder above and below the diagnostic threshold: prevalence, comorbidity and impairment in the general population j Abstract Background There is a lack of data systematically describing subthreshold expressions of social anxiety disorder (SAD) with regard to prevalence , comorbidity, and impairment. Methods This analysis was based on data from the German Health Survey (GHS) and its Mental Health Supplement (GHS-MHS). Social anxiety disorder and its syndromes as well as other mental disorders were assessed with a standardized diagnostic interview (M-CIDI) in 4,174 adults. Results The 12-month prevalence rate for threshold SAD was 2.0%, sub-threshold and symptomatic social anxiety (one DSM-IV criterion missing/two or more criteria missing) was found in 3.0 and 7.5% of the participants, respectively. As expected, threshold SAD was characterized by an elevated risk for comorbid disorders and associated with impairment in diverse areas of life. However, this was also true for the two sub-threshold expressions of social anxiety, which were also significantly associated with higher comorbidity and greater impairment compared to the control group. Conclusions Our results suggest that social anxiety below the diagnostic threshold is clearly associated with adverse outcomes. Prospective designs should examine the exact temporal and possible causal pathways of this burden in order to inform prevention and early intervention programs. j Key words epidemiology – prevalence – social anxiety disorder – social anxiety-impairment