Miracle-dz/UniFAR-FTUs huggingface dataset:
Intensive Benenntherapie für Objekt-Verb-Verbindungen: 2 Einzelfallstudien bei chronischer nicht-flüssiger Aphasie

Zusammenfassung Hintergrund: Obwohl in der klassischen Benenntherapie meist nur an einer Wortart gearbeitet wird, schlagen Autoren vor, Nomen und Verben häufiger kombiniert zu verwenden. Die vorliegende Studie untersuchte, ob der Abruf von Objekt-Verb-Verbindungen durch eine intensive Benenntherapie mit hoher Repetition der einzelnen Items verbessert werden kann. Methode: Aus den im Benenntest überprüften tätigkeitsdarstellenden Videos suchten wir für die beiden Probanden mit chronischer, nicht-flüssiger Aphasie individuell Übungs- und Kontrollitems heraus. In 15 Einzeltherapien wurde eine Lerntherapie erprobt, in der auf den Benennversuch ein klares, einfaches Feedback folgte („richtig“ oder „falsch“) und der Proband daraufhin die Zielform nachsprechen sollte. Parallel zur Therapie überprüften wir regelmäßig untrainierte Sprachaufgaben. Ergebnisse: Beide Probanden verbesserten sich im Benennen der geübten Items signifikant. Jedoch konnte nur bei einem Probanden ein Generalisierungseffekt auf ungeübtes Material nachgewiesen werden. Da die Leistungen in den untrainierten Sprachaufgaben dagegen stabil blieben, kann man die positiven Ergebnisse auf die Therapiemethode zurückführen.
Homeostatic Switch in Hebbian Plasticity and Fear Learning after Sustained Loss of Cav1.2 Calcium Channels

Ca2+ influx through postsynaptic Cav1.x L-type voltage-gated channels (LTCCs) is particularly effective in activating neuronal biochemical signaling pathways that might be involved in Hebbian synaptic plasticity (i.e., long-term potentiation and depression) and learning and memory. Here, we demonstrate that Cav1.2 is the functionally relevant LTCC isoform in the thalamus-amygdala pathway of mice. We further show that acute pharmacological block of LTCCs abolishes Hebbian plasticity in the thalamus-amygdala pathway and impairs the acquisition of conditioned fear. On the other hand, chronic genetic loss of Cav1.2 triggers a homeostatic change of the synapse, leading to a fundamental alteration of the mechanism of Hebbian plasticity by synaptic incorporation of Ca2+-permeable, GluA2-lacking AMPA receptors. Our results demonstrate for the first time the importance of the Cav1.2 LTCC subtype in synaptic plasticity and fear memory acquisition.
Working memory training improves reading processes in typically developing children

The goal of this study was to investigate whether a brief cognitive training intervention results in a specific performance increase in the trained task, and whether there are transfer effects to other nontrained measures. A computerized, adaptive working memory intervention was conducted with 9- to 11-year-old typically developing children. The children considerably improved their performance in the trained working memory task. Additionally, compared to a matched control group, the experimental group significantly enhanced their reading performance after training, providing further evidence for shared processes between working memory and reading.
LOW PSII ACCUMULATION1 Is Involved in Efficient Assembly of Photosystem II in Arabidopsis thaliana[W]

To gain insight into the processes involved in photosystem II (PSII) biogenesis and maintenance, we characterized the low psii accumulation1 (lpa1) mutant of Arabidopsis thaliana, which generally accumulates lower than wild-type levels of the PSII complex. In vivo protein labeling experiments showed that synthesis of the D1 and D2 proteins was greatly reduced in the lpa1 mutant, while other plastid-encoded proteins were translated at rates similar to the wild type. In addition, turnover rates of the PSII core proteins CP47, CP43, D1, and D2 were higher in lpa1 than in wild-type plants. The newly synthesized PSII proteins were assembled into functional protein complexes, but the assembly was less efficient in the mutant. LPA1 encodes a chloroplast protein that contains two tetratricopeptide repeat domains and is an intrinsic membrane protein but not an integral subunit of PSII. Yeast two-hybrid studies revealed that LPA1 interacts with D1 but not with D2, cytochrome b6, or Alb3. Thus, LPA1 appears to be an integral membrane chaperone that is required for efficient PSII assembly, probably through direct interaction with the PSII reaction center protein D1.
Bilateral Parallel Forceeposition Teleoperation Control

The application of parallel force/position control to teleoperation systems is considered in this paper. Higher priority is given to position control at the master side and to force control at the slave side of the teleoperation system. The stability and performance of the proposed controller is investigated by analyzing the three decoupled systems obtained from projecting the closed-loop system dynamics onto the slave task-space orthogonal directions. Experimental results demonstrate the excellent force and position tracking performance provided by the new controller.
Central nervous actions of serotonin and a serotonin1A receptor agonist: cardiovascular excitation at low doses.

Studies were performed in conscious unrestrained rats to compare the cardiovascular effects of i.c. v. administration of serotonin (5-HT) and the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Low doses (less than 10 nmol) of 5-HT and 8-OH-DPAT elicited significant elevations of arterial pressure and heart rate. At doses greater than 10 nmol, 5-HT produced pressor responses attended by significant reductions of heart rate whereas 8-OH-DPAT produced significant depressor and bradycardiac responses. Concurrent i.c. v. administration of the nonselective 5-HT receptor antagonist, methiothepin, abolished the cardiovascular responses to a low (1 nmol) and a high (100 nmol) dose of 5-HT and a low (3 nmol) dose of 8-OH-DPAT. In contrast, methiothepin cotreatment did not prevent the reductions of arterial pressure and heart rate induced by a high (100 nmol) dose of 8-OH-DPAT. These results suggest that stimulation of central nervous system 5-HT1A receptors with low doses of 8-OH-DPAT produces cardiovascular activation.
Genetics, governance and ethics

In this second issue of Critical Public Health featuring the ‘new’ genetics and governance we include work from researchers across a number of countries. Issue 12(2) included work illustrating the ways that the ‘new’ genetics involves public health in governance, particularly over issues of ethics.We noted that, although not always acknowledged as such, interventions such as parental genetic counselling, the creation of national genetic databases and the transmission of knowledge in health education campaigns in uence and de ne social relationships in purposeful ways.These newer technologies are seen to raise ‘ethical’ issues, perhaps because of their governing effects. The ethical concerns of individuals are central to their self-care regimes and ultimately their formation as active health practising citizens. In the  rst issue, we pointed to the importance of Michel Foucault’s work in thinking about governance and ethics, and their relationship. Foucault was concerned with ethical conduct and its capacity to engender particular types of discipline in society (Foucault, 1975, 1977). He developed the concept of governmentality (Foucault 1991) to account for the varied means of assuring the capacity for governance. He had an abiding interest in ‘bio-power’—the capacity of biological systems of knowledge and technique to supplant social means of reproduction. Foucault understood the term as to designate, that which ‘brought life and its mechanisms into the realm of explicit calculations and made knowledge-power an agent of transformation of human life’ (Foucault, 1979, p. 143). As we are about to go to press, a major report of the World Health Organization, entitled Genomics and World Health, has been released, underlining not only the contemporary signi cance of the new genetics for public health but also the urgent need for new tools of analysis in this area, such as those offered by Foucault and his followers.The Report notes that the public health implications of genomics are of a global order, and include developments in pharmacogenetics, gene therapy, stem cell therapy, agriculture and vector control. In the developing world, the new genetics is seen to hold great promise in the  ght against infectious disease, in enhancing the nutritional values of crop species, and in the treatment of groupor region-speci c diseases, such as the thalassaemias and sickle cell disease (WHO, 2002, p. 44). However, the Report also offers a number of cautionary notes in relation to these Critical Public Health,Vol. 12, No. 3, 2002
Designing, Fabrication and Characterization of Power Amplifiers Based on 10-Watt SiC MESFET & GaN HEMT at Microwave Frequencies

This paper describes the design, fabrication and measurement of two single-stage class-AB power amplifiers covering the frequency band from 0.7-1.8 GHz using a SiC MESFET and a GaN HEMT. The measured maximum output power for the SiC amplifier at Vd = 48 V was 41.3 dBm (~13.7 W), with a PAE of 32% and a power gain above 10 dB. At a drain bias of Vd= 66 V at 700 MHz the Pmax was 42.2 dBm (~16.6 W) with a PAE of 34.4%. The measured results for GaN amplifier are; maximum output power at Vd = 48 V is 40 dBm (~10 W), with a PAE of 34% and a power gain above 10 dB. The results for SiC amplifier are better than for GaN amplifier for the same 10-W transistor.
TOR-dependent reduction in the expression level of Rrn3p lowers the activity of the yeast RNA Pol I machinery, but does not account for the strong inhibition of rRNA production

Ribosome biogenesis is tightly linked to cellular growth. A crucial step in the regulation of ribosomal RNA (rRNA) gene transcription is the formation of the complex between RNA polymerase I (Pol I) and the Pol I-dependent transcription factor Rrn3p. We found that TOR inactivation leads to proteasome-dependent degradation of Rrn3p and a strong reduction in initiation competent Pol I–Rrn3p complexes affecting yeast rRNA gene transcription. Using a mutant expressing non-degradable Rrn3p or a strain in which defined endogenous Rrn3p levels can be adjusted by the Tet-off system, we can demonstrate that Rrn3p levels influence the number of Pol I–Rrn3p complexes and consequently rRNA gene transcription. However, our analysis reveals that the dramatic reduction of rRNA synthesis in the immediate cellular response to impaired TOR signalling cannot be explained by the simple down-regulation of Rrn3p and Pol I–Rrn3p levels.
Visible Zone Maintenance for Real-Time Occlusion Culling

Interactive rendering of a large, dense environment can be accelerated by keeping track of the visible objects. We introduce a framework for maintaining the visible set that provides perfect occluder fusion while taking advantage of temporal coherence in the observer’s position. The method is based on maintaining a visible zone, a spatial decomposition that supports fast visibility queries and efficient updates. We discuss visible zone maintenance in 2 and 2.5 dimensions, and present extensions to maintain conservative visibility for complex geometry. We present results from an interactive flythrough of a forest environment with one million trees and seven billion polygons.
A Critique of Divorce Statistics and Their Interpretation.

The author develops a hypothesis as to why divorce statistics are invalid or unreliable as indicators of the present state of marriage and the family. Various aspects of the collection of divorce statistics in the United States are criticized including the methods of calculating divorce statistics; variations between states in calculation procedures; the differentiation between first and higher order marriages; methodologies to calculate desertions annulments and separations; and comparisons with referent periods (ANNOTATION)
C/C++ Preprocessing with modern data storage devices

The progress of hardware evolution cannot be stopped. Not just new CPUs and memory modules are invented but new kind of data storage devices appeared. Typically the programming languages do not follow all the changes in hardware. Solid-state drives (SSD) are improved data storage devices in order to reach must faster read and write speed than hard disk drives. Nowadays the solid-state drives have become popular. The high number of I/O operations have some performance drawbacks during build. In this paper we analyze how the data storage device affects C/C++ preprocessor operations because this is an I/O-intensive task and many researches target the speed-up of preprocessing workflow. We present our measurement framework that helps us to analyze different approaches. We focus on the following questions: Is it worth to use unity build or another technique when SSD is available? How can we take advantage of solid-state drive when we work with preprocessor? What are pros and cons when preprocessor works with these new devices?
Teaching and Learning to Teach: The Two Roles of Beginning Teachers

Four case studies are presented that reveal the unique induction experiences of 3 elementary teachers and 1 secondary teacher over 2½ years. Based on data from semistructured interviews and several secondary sources, the cases show the influence of 4 major factors-students, colleagues, school context, and parents-on beginning teachers' socialization. We argue that beginners have 2 roles, teaching effectively and learning to teach, and that induction programs should recognize and support both roles. From the cases, we show that learning to teach is a highly individualized process that varies according to beginners' beliefs and expectations about teaching and the teaching situations they encounter. Because teaching is inherently complex and performed under conditions that can vary significantly from year to year, induction takes time, as much as 3 years, and requires the support of understanding colleagues. We conclude with a description of 1 successful induction program involving 70 pairs of beginners and mentors. Included are details about the roles and strategies of mentors and the importance of developing clear expectations among participants concerning the purpose and control of induction programs.
Differences in Estrogen Receptor Subtype According to Family History of Breast Cancer among Hispanic, but not Non-Hispanic White Women

Background: Pathologic differences have been reported among breast tumors when comparing ethnic populations. Limited research has been done to evaluate the ethnic-specific relationships between breast cancer risk factors and the pathologic features of breast tumors. Methods: Given that genetic variation may contribute to ethnic-related etiologic differences in breast cancer, we hypothesized that tumor characteristics differ according to family history of breast cancer among Hispanic and non-Hispanic White (NHW) women. Logistic regression models were used to compute odds ratios (OR) and 95% confidence intervals (95% CI) to assess this relationship in the population-based, case-control 4-Corners Breast Cancer Study (1,537 cases and 2,452 controls). Results: Among Hispanic women, having a family history was associated with a 2.7-fold increased risk of estrogen receptor (ER) negative (95% CI, 1.59-4.44), but not ER positive tumors (OR, 1.04; 95% CI, 0.71-1.54) when compared with women without breast cancer. In contrast, there was an increased risk for ER positive (OR, 1.89; 95% CI, 1.50-2.38) and a marginally significant increased risk for ER negative tumors (OR, 1.41; 95% CI, 0.92-2.17) among NHW women. When comparing tumor characteristics among invasive cases, those with a family history also had a significantly higher proportion of ER negative tumors among Hispanics (39.2% versus 25.8%; P = 0.02), but not among NHWs (16.3% versus 21.1%; P = 0.13). Conclusions: These results may reflect ethnic-specific predisposing genetic factors that promote the development of specific breast tumor subtypes, and emphasize the importance of evaluating the relationship between breast cancer risk factors and breast tumor subtypes among different ethnic populations. (Cancer Epidemiol Biomarkers Prev 2008;17(10):2700–6)
On resistive open defect detection in DRAMs: The charge accumulation effect

The test complexity of high density DRAMs increases with technology evolution, due to a larger impact of process variation and weak defects. In particular, resistive open defects turn to be a major concern in DRAMs. Our analysis and simulation results show that an important phenomenon exists, charge accumulation, which is currently not considered in DRAM testing. Charge accumulation occurs in DRAM cells that suffer from internal resistive opens; a weak value stored at a cell is strengthened when a sequence of read operations is applied to it. Typical DRAM testing procedures (like March tests) fail to provide enhanced coverage of resistive open defects, since they do not consider charge accumulation. This paper provides an effective test algorithm that targets resistive open defects, while considering the bit-line imbalance and the charge accumulation mechanisms.
Evolved Cognition and Cultural Transmission of Honour Concepts

Abstract In many cultures people value the importance of honour and related rules and behaviours. Honour can be seen as concepts and cultural items represented and processed according to evolved cognitive capacities and emotions supported by local social institutional arrangements. Indeed, this article holds that one reasonable way to analyze honour is to model how cognitive processes and transmission biases work in tandem with institutional support and environmental cues to exert selective pressures on the cultural distribution and formation of honour. The scope of this article is theoretical, aiming to address and explain culturally recurrent aspects of widespread honour concepts. What evolved cognitive systems and selection factors underpin the cultural transmission of honour concepts and institutions? It will be argued that the transmission of honour concepts draws upon cognitive systems referring to male formidability, management of reputation, coalitions, costly signals, shame and stigma, concern for protectiveness and parental investments, essentialist understanding and disgust and on the cognition of institutions.
Intellectual Disability: A Concept in Need of Revision?

It is suggested that the way the term intellectual disability is used gives the impression that it is a discrete entity which can be diagnosed simply by assessing an individual’s level of adaptive behaviour and IQ. It is argued that we are not able to measure either adaptive behaviour or IQ with sufficient accuracy. A looser definition of intellectual disability is suggested, acknowledging the problems in measurement and emphasising the need for clinical judgment.
Locating internet bottlenecks: algorithms, measurements, and implications

The ability to locate network bottlenecks along end-to-end paths on the Internet is of great interest to both network operators and researchers. For example, knowing where bottleneck links are, network operators can apply traffic engineering either at the interdomain or intradomain level to improve routing. Existing tools either fail to identify the location of bottlenecks, or generate a large amount of probing packets. In addition, they often require access to both end points. In this paper we present Pathneck, a tool that allows end users to efficiently and accurately locate the bottleneck link on an Internet path. Pathneck is based on a novel probing technique called Recursive Packet Train (RPT) and does not require access to the destination. We evaluate Pathneck using wide area Internet experiments and trace-driven emulation. In addition, we present the results of an extensive study on bottlenecks in the Internet using carefully selected, geographically diverse probing sources and destinations. We found that Pathneck can successfully detect bottlenecks for almost 80% of the Internet paths we probed. We also report our success in using the bottleneck location and bandwidth bounds provided by Pathneck to infer bottlenecks and to avoid bottlenecks in multihoming and overlay routing.
A benchmark suite for substrate analysis

The paper proposes an initial benchmark set, suitable for substrate analysis and test. The aim is to help accurately represent electrical noise injected into and picked up from substrate in a variety of high performance circuits. Creating an accurate image of such noise is becoming a critical requirement with the expansion of real plug-and-play style designs. Several important methods for the analysis of substrate parasitic coupling are reviewed in light of the effect substrate noise has on the performance of analog and digital ICs over a wide frequency spectrum. The requirements and formats for each benchmark are described in full detail to allow possible algorithmic as well as signal integrity tests.
A Comparative Study of Work Organization and Supervisory Behavior

The man behind the man behind the bench—the first line supervisor or foreman has become a critical figure in industrial management.1 He has been referred to as "the forgotten man," "the master and victim of double talk,"2 "the Janus-Faced,"3 "the marginal man,"4 and "the Achilles heel. "5
Using RT-CORBA Scheduling Service And Prioritized Network Traffic to Achieve End-to-End Predictability

Computing systems are increasingly distributed, realtime, and embedded (DRE) and must operate under highly unpredictable and changeable conditions. To provide predictable mission-critical quality of service (QoS) end-to-end, QoS-enabled middleware services and mechanisms have begun to emerge. It is also, widely known that Control Area Networks (CAN) are used in real-time, distributed and parallel processing which cover manufacture plants, humanoid robots, networking fields. We show how prioritization of messages over the physical CAN network can be achieved, when adopting the use of RT-CORBA distributed scheduling service which implements a dynamic scheduling policy to achieve end-to-end predictability and performance.
An Analytical Model for CMUTs with Square Multilayer Membranes Using the Ritz Method

Capacitive micromachined ultrasonic transducer (CMUT) multilayer membrane plays an important role in the performance metrics including the transmitting efficiency and the receiving sensitivity. However, there are few studies of the multilayer membranes. Some analytical models simplify the multilayer membrane as monolayer, which results in inaccuracies. This paper presents a new analytical model for CMUTs with multilayer membranes, which can rapidly and accurately predict static deflection and response frequency of the multilayer membrane under external pressures. The derivation is based on the Ritz method and Hamilton’s principle. The mathematical relationships between the external pressure, static deflection, and response frequency are obtained. Relevant residual stress compensation method is derived. The model has been verified for three-layer and double-layer CMUT membranes by comparing its results with finite element method (FEM) simulations, experimental data, and other monolayer models that treat CMUTs as monolayer plates/membranes. For three-layer CMUT membranes, the relative errors are ranging from 0.71%–3.51% for the static deflection profiles, and 0.35%–4.96% for the response frequencies, respectively. For the double-layer CMUT membrane, the relative error with residual stress compensation is 4.14% for the central deflection, and −1.17% for the response frequencies, respectively. This proposed analytical model can serve as a reliable reference and an accurate tool for CMUT design and optimization.