Miracle-dz/UniFAR-FTUs huggingface dataset:
The transcriptional diversity of 25 Drosophila cell lines.

Drosophila melanogaster cell lines are important resources for cell biologists. Here, we catalog the expression of exons, genes, and unannotated transcriptional signals for 25 lines. Unannotated transcription is substantial (typically 19% of euchromatic signal). Conservatively, we identify 1405 novel transcribed regions; 684 of these appear to be new exons of neighboring, often distant, genes. Sixty-four percent of genes are expressed detectably in at least one line, but only 21% are detected in all lines. Each cell line expresses, on average, 5885 genes, including a common set of 3109. Expression levels vary over several orders of magnitude. Major signaling pathways are well represented: most differentiation pathways are "off" and survival/growth pathways "on. " Roughly 50% of the genes expressed by each line are not part of the common set, and these show considerable individuality. Thirty-one percent are expressed at a higher level in at least one cell line than in any single developmental stage, suggesting that each line is enriched for genes characteristic of small sets of cells. Most remarkable is that imaginal disc-derived lines can generally be assigned, on the basis of expression, to small territories within developing discs. These mappings reveal unexpected stability of even fine-grained spatial determination. No two cell lines show identical transcription factor expression. We conclude that each line has retained features of an individual founder cell superimposed on a common "cell line" gene expression pattern.
Participation and e-democracy how to utilize web 2.0 for policy decision-making

This paper investigates in how to utilize ICT and Web 2.0 technologies and e-democracy software for policy decision-making. It introduces a cutting edge decision-making system that integrates the practice of e-petitions, e-consultation, e-rulemaking, e-voting, and proxy voting. The paper demonstrates how under precondition of direct democracy through the use this system the collective intelligence (CI) of a population would be gathered and used throughout the policy process.
Friction Reduction of Lubricant Base Oil by Micelles and Crosslinked Micelles of Block Copolymers

Diblock copolymers with one block soluble and the other block insoluble were dispersed in an industrial base oil (BO) to yield spherical micelles (SMs). SMs were also prepared in more manageable solvents that had similar solubility properties as the BO towards the copolymers but had lower viscosities and lower boiling points and absorbed less in the near UV region. The photocrosslinking of the cores of the latter micelles yielded crosslinked micelles or nanospheres. We have tested the lubrication properties of the micelle and nanosphere samples in BO under conditions simulating those found in automobile engines. Solutions of micelles and nanospheres with 2-cinnamoyloxyethyl acrylate units in their cores exhibited a unique friction reduction pattern and had friction coefficients that were significantly lower in the boundary lubrication regime (BLR) than in the mixed lubrication regime. Such particles reduced the friction of the BO by > 70% in the BLR and performed substantially better than the widely used industrial anti-friction agent glyceryl monooleate. The factors affecting this unique friction reduction behavior were investigated and a possible reason for it was proposed.
Speech enhancement using Kalman filters for restoration of short-time DFT trajectories

In this paper a time-frequency estimator for enhancement of noisy speech signals in the DFT domain is introduced. This estimator is based on modeling and filtering the temporal trajectories of the DFT components of noisy speech signal using Kalman filters. The time-varying trajectory of the DFT components of speech is modeled by a low order autoregressive (AR) process incorporated in the state equation of Kalman filter. A method is incorporated for restarting of Kalman filters, after long periods of noise-dominated activity in a DFT channel, to mitigate distortions of the onsets of speech activity. The performance of the proposed method for the enhancement of noisy speech is evaluated and compared with MMSE estimator and parametric spectral subtraction. Evaluation results show that the incorporation of temporal information through Kalman filters results in reduced residual noise and improved perceived quality of speech
Défi EGC 2017: Modélisation Cost-Sensitive et Enrichissement de données

Résumé. La conférence EGC’2017 propose un défi dont le contexte est la gestion des espaces verts pour la ville de Grenoble, et notamment des arbres qui y sont présents. L’objectif est de proposer un modèle basé sur des données fournies qui permettrait de prédire au mieux les arbres malades, ainsi que la localisation potentielle de la maladie. Après avoir obtenu quelques résultats intéressants avec des modèles standards, notre approche utilisant un modèle Cost-Sensitive One Against All (CSOAA) nous permet d’obtenir une exactitude de 0,86, une précision de 0,88, et un rappel de 0,91 sur la prédiction unilabel, et une précision/rappel micro de 0,82/0,74 ainsi qu’une précision/rappel macro de 0,66/0,46 pour la prédiction multilabel. L’extraction de connaissances pour la tâche 2 nous a permis de mettre en relief l’intérêt de l’ajout de données sur la nature des maladies et la concentration de la pollution dans la ville.
Forecasting Volatility in Financial Markets

In this paper, we analyze the stock of Tsingtao Brewery Co Ltd for the 8-year period, from July 31, 2001, to September 11, 2009, a total of 2003 trading days. Using the False Nearest Neighbors method, we obtain the embedding dimension m in the k-nearest neighbour Algorithm. In order to investigate the validity of this method, we apply the modified method to the daily adjusted opening values of the Tsingtao Brewery Co Ltd. We find that the prediction of experimental results is more accurate than traditional methods.
Vertical-cavity surface-emitting lasers: effects of heating on modal characteristics and threshold current

Vertical-cavity surface-emitting lasers (VCSELs) have unique properties that distinguish them from conventional edge-emitting semiconductor lasers and render them very attractive for a number of novel applications. In addition to those distinguishing features, due to intense heating the role of thermal effects in VCSELs is by far more prominent than in edge emitters. In this paper, a brief review is given of some of VCSEL properties influenced by temperature. Effects of temperature on spectral device characteristics are discussed, including the temperature dependence of the longitudinal mode spectra and the transverse-mode structure. A new condition is formulated for thermal matching of the Bragg mirrors and the spacer region. Temperature sensitivity of threshold current is also considered, and the dominant role of the gain peak/cavity resonance detuning is described.
Predictive factors for obtaining a correct therapeutic range using antivitamin K anticoagulants: a tertiary center experience of patient adherence to anticoagulant therapy

Background Patient adherence is an essential factor in obtaining efficient oral anticoagulation using vitamin K antagonists (VKAs), a situation with a narrow therapeutic window. Therefore, patient education and awareness are crucial for good management. Auditing the current situation would help to identify the magnitude of the problem and to build tailored education programs for these patients. Methods This study included 68 hospitalized chronically anticoagulated patients (mean age 62.6±13.1 years; males, 46%) who responded to a 26-item questionnaire to assess their knowledge on VKA therapy management. Laboratory and clinical data were used to determine the international normalized ratio (INR) at admission, as well as to calculate CHA2DS2-VASC and HAS-BLED scores for patients with atrial fibrillation. Results The majority of patients (62%) were receiving VKA for atrial fibrillation, the others for a mechanical prosthesis and previous thromboembolic disease or stroke. In the atrial fibrillation group, the mean CHA2DS2-VASC score was 3.1±1.5, while the average HAS-BLED score was 1.8±1.2. More than half of the patients (53%) had an INR outside of the therapeutic range at admission, with the majority (43%) having a low INR. A correct INR value was predicted by education level (higher education) and the diagnostic indication (patients with mechanical prosthesis being best managed). Patients presenting with a therapeutic INR had a trend toward longer treatment duration than those outside the therapeutic range (62±72 months versus 36±35 months, respectively, P=0.06). There was no correlation between INR at admission and the patient’s living conditions, INR monitoring frequency, and bleeding history. Conclusion In a tertiary cardiology center, more than half of patients receiving VKAs are admitted with an INR falling outside the therapeutic range, irrespective of the bleeding or embolic risk. Patients with a mechanical prosthesis and complex antithrombotic regimens appear to be the most careful with INR monitoring, especially if they have a higher level of education. Identifying patient groups with the lowest time interval spent in the therapeutic range could help attending physicians educate patients focusing on specific awareness issues.
The Application and Simulation Research of the Fuzzy PID Control Used in PVC Polymerization Temperature Control System

The process of PVC polymerization is nonlinear and time-delayed. It is very difficult to establish an exact mathematical model. Based on the analysis of the conventional PID controller’s limitation, the fuzzy PID control system of PVC polymerization is introduced. A new kind of fuzzy PID controller is designed and the three parameters of PID can be self-tuned on-line. The simulation result proves that fuzzy PID controller is better than common PID controller.
Is more always merrier?: a deep dive into online social footprints

We present an empirical study of personal information revealed in public profiles of people who use multiple Online Social Networks (OSNs). This study aims to examine how users reveal their personal information across multiple OSNs. We first consider the number of publicly available attributes in public profiles, based on various demographics and show a correlation between the amount of information revealed in OSN profiles and specific occupations and the use of pseudonyms. Then, we measure the complementarity of information across OSNs and contrast it with our observations about users who share a larger amount of information. We also measure the consistency of information revelation patterns across OSNs, finding that users have preferred patterns when revealing information across OSNs. To evaluate the quality of aggregated profiles we introduce a consistency measure for attribute values, and show that aggregation also improves information granularity. Finally, taking Australian phone directory as a case study, we demonstrate how the availability of multiple OSN profiles can be exploited to improve the success of obtaining users' detailed contact information, by cross-linking with publicly available data sources such as on-line phone directories.
Microglial/macrophage expression of interleukin 10 in human glioblastomas

Interleukin 10 (IL‐10) expression has been found to be correlated with the extent of malignancy in gliomas. In vitro, IL‐10 increases proliferation and migratory capacity in human glioma cell lines. In this study, we localized the site of IL‐10 synthesis in gliomas to cells of microglial origin. Biopsy specimens from 11 patients with malignant glioma were processed on native tissues and at early cell culture passages (0–4). IL‐10 mRNA was analyzed by RT‐PCR and in situ hybridization. Protein was quantitatively assessed by ELISA in cell culture supernatants, and cells expressing IL‐10 were determined by a combination of immunohistochemistry for CD68 (specific for microglia/macrophage lineage) and IL‐10 in situ hybridization. IL‐10 mRNA decreased from passage 0 to 4 in all samples and was undetectable beyond passage 5. Such downregulation of mRNA leads to a steep decrease of IL‐10 protein in culture supernatants (below detection level, 0.05 ng/ml, beyond passage 1). The combination of in situ hybridization for IL‐10 and CD68 immunostaining revealed that only cells of the microglia/macrophage lineage produced IL‐10 mRNA. Our results identify microglia/macrophage cells as the major source of IL‐10 expression in gliomas which decreases markedly during early passages of primary cultures of human gliomas due to a progressive reduction of microglia/macrophages present. Int. J. Cancer 82:12–16, 1999. © 1999 Wiley‐Liss, Inc.
Genetic differentiation, hybridization and adaptive divergence in two subspecies of the acorn barnacle Tetraclita japonica in the northwestern Pacific

Two acorn barnacles, Tetraclita japonica japonica and Tetraclita japonica formosana, have been recently reclassified as two subspecies, because they are morphologically similar and genetically indistinguishable in mitochondrial DNA sequences. The two barnacles are distinguishable by parietes colour and exhibit parapatric distributions, coexisting in Japan, where T. j. formosana is very low in abundance. Here we investigated the genetic differentiation between the subspecies using 209 polymorphic amplified fragment length polymorphism markers and 341 individuals from 12 locations. The subspecies are genetically highly differentiated (ΦCT = 0.267). Bayesian analysis and principal component analysis indicate the presence of hybrids in T. j. formosana samples from Japan. Strong differentiation between the northern and southern populations of T. j. japonica was revealed, and a break between Taiwan and Okinawa was also found in T. j. formosana. The differentiation between the two taxa at individual loci does not deviate from neutral expectation, suggesting that the oceanographic pattern which restricts larval dispersal is a more important factor than divergent selection in maintaining genetic and phenotypic differentiation. The T. j. formosana in Japan are probably recent migrants from Okinawa, and their presence in Japan may represent a poleward range shift driven by global warming. This promotes hybridization and might lead to a breakdown of the boundary between the subspecies. However, both local adaptation and larval dispersal are crucial in determining the population structure within each subspecies. Our study provides new insights into the interplay of local adaptation and dispersal in determining the distribution and genetic structure of intertidal biota and the biogeography of the northwestern Pacific.
An Adaptive Genetic Algorithm for Permutation Based Optimization Problems

Genetic Algorithms (GA) are a robust heuristic search technique capable of taking on a broad range of optimization problems. In most GAs, components and parameters are predetermined and remain static throughout its run. Much research has indicated that improvements to its performance can be sought by varying some of these components and parameters during its appli cation on a problem. In this paper, a brief survey of the techniques used to vary the GA’s components and parameters is presented. We hypothesize that a GA’s performance and robustness can be enhanced through the ‘online’ adaptation of the operators. An operator based adaptive genetic algorithm (AGA) based on these concepts is designed and implemented. A number of permutation based problems were selected to evaluate the performance of AGA.
Comparison of Euryarchaea Strains in the Guts and Food-Soil of the Soil-Feeding Termite Cubitermes fungifaber across Different Soil Types

ABSTRACT Termites are an important component of tropical soil communities and have a significant effect on the structure and nutrient content of soil. Digestion in termites is related to gut structure, gut physicochemical conditions, and gut symbiotic microbiota. Here we describe the use of 16S rRNA gene sequencing and terminal-restriction fragment length polymorphism (T-RFLP) analysis to examine methanogenic archaea (MA) in the guts and food-soil of the soil-feeder Cubitermes fungifaber Sjostedt across a range of soil types. If these MA are strictly vertically inherited, then the MA in guts should be the same in all individuals even if the soils differ across sites. In contrast, gut MA should reflect what is present in soil if populations are merely a reflection of what is ingested as the insects forage. We show clear differences between the euryarchaeal communities in termite guts and in food-soils from five different sites. Analysis of 16S rRNA gene clones indicated little overlap between the gut and soil communities. Gut clones were related to a termite-derived Methanomicrobiales cluster, to Methanobrevibacter and, surprisingly, to the haloalkaliphile Natronococcus. Soil clones clustered with Methanosarcina, Methanomicrococcus, or rice cluster I. T-RFLP analysis indicated that the archaeal communities in the soil samples differed from site to site, whereas those in termite guts were similar between sites. There was some overlap between the gut and soil communities, but these may represent transient populations in either guts or soil. Our data do not support the hypothesis that termite gut MA are derived from their food-soil but also do not support a purely vertical transmission of gut microflora.
Digitizing fashion

of how, specifically, these devices should vary in their expression. This trend started with the phenomenal success of mobile phones. The complex relationship between the use of mobile devices and the consumption of fashionable clothing has been identified and discussed in sociology and HCI [1]. Since we interact with mobile phones in close physical proximity to our bodies and clothes, we have a similar interest in their beautification. That relationship is likely to increase, given the growing interest in manufacturing and commercializing smart watches. There is an ongoing trend of digital devices being used in close physical proximity to our bodies, in the same position as our clothes. It started with the success of mobile phones, continues with the emergent use of smart watches and smart eyewear, and is leading to a future of smart textiles and organic user interfaces. These devices provide public visual surfaces with possibilities for endless variation of visual expression. With the emergence of wearable hardware, we foresee the need to develop fashion-oriented software, services, and applications. The question then arises Insights → Many wearable devices provide public visual surfaces with possibilities for endless variation of aesthetic expression. → To leverage these new expressive possibilities, fashion designers should be included in the making of software and services. → Fashionable wearable services and software could one day interact with people's clothing ensembles.
Chronic Cortical and Subcortical Pathology with Associated Neurological Deficits Ensuing Experimental Herpes Encephalitis

Long‐term neurological sequela is common among herpes simplex encephalitis (HSE) survivors. Animal models for HSE are used to investigate mechanisms of acute disease, but little has been done to model chronic manifestations of HSE. The current study presents a detailed, systematic analysis of chronic neuropathology, including characterization of topography and sequential progression of degenerative lesions and inflammation. Subsequent to intranasal HSV‐1 infection, inflammatory responses that were temporally and spatially distinct persisted in infected cortical and brain stem regions. Neutrophils were present exclusively within the olfactory bulb and brain stem regions during the acute phase of infection, while the chronic inflammation was marked by plasma cells, lymphocytes and activated microglia. The chronic lymphocytic infiltrate, cytokine production, and activated microglia were associated with the loss of cortical neuropile in the entorhinal cortex and hippocampus. Animals surviving the acute infection showed a spectrum of chronic lesions from decreased brain volume, neuronal loss, activated astrocytes, and glial scar formation to severe atrophy and cavitations of the cortex. These lesions were also associated with severe spatial memory deficits in surviving animals. Taken together, this model can be utilized to further investigate the mechanisms of neurological defects that follow in the wake of HSE.
Analysis and Optimization of Supply Chain Traffic using Mobility Mining Techniques

mobile objects in the supply chain present the means of transportation, and they have an influence on the functioning of the supply chain. The mobile object bring a correct information, where and when necessities, to reduce the uncertainty, increase the visibility of products and increase the global efficiency of the supply chain. The supply chain is a system characterized by the mobility between the various processes of the chain as well as the mobility pattern of materials including the vehicle which carries in transportation network. Mobility mining is the process of extracting hidden knowledge from moving object trajectories. This is a concept paper which visualizes the scope of various mobility mining techniques for analysis and optimization of objects moving in transportation network. Also we demonstrate how the trajectory similarity technique which is one of the mobility mining technique could be used for an efficient and effective supply chain infrastructure.
Impact of a school-based food garden on attitudes and identification skills regarding vegetables and fruit: a 12-month intervention trial

Abstract Objective To determine changes in ability to identify specific vegetables and fruits, and attitudes towards vegetables and fruit, associated with the introduction of a school-based food garden. Design A 12-month intervention trial using a historical control (control n 132, intervention n 120), class-based, self-administered questionnaires requiring one-word answers and 3-point Likert scale responses. Setting A state primary school (grades 4 to 7) in a low socio-economic area of Brisbane, Australia. Intervention The introduction of a school-based food garden, including the funding of a teacher coordinator for 11 h/week to facilitate integration of garden activities into the curriculum. Main outcome measures Ability to identify a series of vegetables and fruits, attitudes towards vegetables and fruit. Analysis Frequency distributions for each item were generated and χ2 analyses were used to determine statistical significance. Exploratory factor analysis was employed to detect major trends in data. Results The intervention led to enhanced ability to identify individual vegetables and fruits, greater attention to origins of produce (garden-grown and fresh), changes to perceived consumption of vegetables and fruits, and enhanced confidence in preparing fruit and vegetable snacks, but decreased interest in trying new fruits. Conclusions The introduction of this school-based food garden was associated with skill and attitudinal changes conducive to enhancing vegetable and fruit consumption. The ways in which such changes might impact on dietary behaviours and intake require further analysis.
Resonant Raman scattering studies of Cd1-xZnxS nanocrystals

Optical phonons in Cd1-xZnxS nanocrystals embedded in borosilicate glass are studied by resonant Raman scattering. A Raman-based assessment of the nanocrystal composition is performed. Compositional dispersion of the nanocrystals within the ensemble is revealed. The effect of confinement-related selection rules relaxation, scattering by surface phonons, and host matrix pressure on the Raman lineshape is analyzed.