Miracle-dz/UniFAR-FTUs huggingface dataset:
Micropuncture study of the mammalian urinary concentrating mechanism: evidence for the countercurrent hypothesis.

The osmolality was determined of fluid collected by micropuncture from proximal and distal convolutions, loops of Henle, collecting ducts and vasa recta of kidneys of various rodents with and without osmotic diuresis. Proximal tubular fluid was isosmotic; in the presence of antidiuretic hormone, early distal fluid was hypo-osmotic due to the prior reabsorption of sodium chloride, and late distal fluid again isosmotic. The hyperosmotic concentration of the urine is established in the collecting ducts, apparently as a consequence, in part at least, of the hyperosmotic reabsorption of sodium chloride in the loops of Henle. Fluid from the bends of loops of Henle, and from collecting ducts and vasa recta at the same level were equally hyperosmotic, consistent with the hypothesis that the mammalian nephron functions as a countercurrent multiplier system. The vasa recta are believed to play an important role in the concentration of the urine by functioning as countercurrent diffusion exchangers.
variPiano™: A parametric design variable piano visualizing a differential tuning mobile interface

This paper introduces the framework of mobile Computer Music interfaces within the context of Human Computer Interaction (HCI). It examines the unique problems posed by the use of computers by composers and performers of music. It emphasizes on the new various interfacing protocols, metaphors and paradigms that apply HCI design methodologies on the world of music, producing special modules like: performance instruments, digital audio processing tools, haptic - adaptable interfaces. A presentation of the basic concepts involved in the Computer Music world prevails the discussion on the evaluation criteria for Computer Music interfaces. New criteria are introduced, like knowledge representation of musical data and alternate musical interfaces materialization. A survey of various systems, based on the previously mentioned criteria is committed.
Applying Genomic and Bioinformatic Resources to Human Adenovirus Genomes for Use in Vaccine Development and for Applications in Vector Development for Gene Delivery

Technological advances and increasingly cost-effect methodologies in DNA sequencing and computational analysis are providing genome and proteome data for human adenovirus research. Applying these tools, data and derived knowledge to the development of vaccines against these pathogens will provide effective prophylactics. The same data and approaches can be applied to vector development for gene delivery in gene therapy and vaccine delivery protocols. Examination of several field strain genomes and their analyses provide examples of data that are available using these approaches. An example of the development of HAdV-B3 both as a vaccine and also as a vector is presented.
Development of standardized methods for analysis of changes in antibacterial use in hospitals from 18 European countries: the European Surveillance of Antimicrobial Consumption (ESAC) longitudinal survey, 2000-06.

OBJECTIVES Our objective was to develop and test standardized methods for collection and statistical analysis of longitudinal data on hospital antibacterial use from different countries. METHODS We collected data on monthly supply of antibiotics from pharmacies in one hospital from each of 18 European countries. We applied a standardized method to classify drugs, measure use in defined daily doses and compare the effect of using occupied bed-days (OBDs) or admissions as denominators for longitudinal analysis. RESULTS Antibiotic use increased in 14 (78%) hospitals and decreased in 4 hospitals. For 16 (89%) hospitals, adjustment of antibiotic use with OBDs resulted in larger changes over time than adjustment with admissions. Inclusion of all hospital clinical activity variables (admissions, length of stay and OBDs) in multivariate time series analysis identified distinct hospital groups. Nine (50%) hospitals had statistically significant changes in antibiotic use (six increasing and three decreasing) that were not explained (n = 3) or only partially explained (n = 6) by change in clinical activity. Three (17%) hospitals had no significant change in antibiotic use. In the remaining six hospitals, apparent changes in antibiotic use were largely explained by changes in clinical activity. CONCLUSIONS This is the first study to use a standardized method for data collection and longitudinal analysis of antibiotic use in different hospitals. These data suggest that determination of changes in antibiotic exposure of hospital patients over a period of time is unreliable if only one clinical activity variable (such as OBDs) is used as the denominator. We recommend inclusion of admissions, OBDs and length of stay in statistical, time series analysis of antibiotic use. This model is also relevant to longitudinal analysis of infections in hospitals.
On compositional semantics

We prove a theorem stating that any semantics can be encoded as a compositional semantics, which means that, essentially, the standard definition of compositionality is formally vacuous. We then show that when one requires compositional semantics to be "systematic" (that is the meaning function cannot be arbitrary, but must belong to some class), one can easily distinguish between compositional and non-compositional semantics. We also present an example of a simple grammar for which there is no "systematic" compositional semantics. This implies that it is possible to distinguish "good" and "bad" grammars on the basis of whether they can have compositional semantics. As a result, we believe that the paper clarifies the concept of compositionality and opens a possibility of making systematic comparisons of different systems of grammars and NLU programs.
Evaluation of land‐use change effects on runoff and soil erosion of a hilly basin — the Yanhe River in the Chinese Loess Plateau

Starting in 1999, the Grain‐for‐Green Programme has been implemented in the Loess Plateau to alleviate the severe soil erosion by converting steeply sloping croplands to forestlands or grasslands. To quantify the effects of these conservation efforts, this study identified the land‐use changes between 2000 and 2015 and quantified their impacts on runoff and erosion using the Soil and Water Assessment Tools (SWAT) and a typical hilly basin, the Yanhe River basin as a case‐study. To heighten the applicability of SWAT to the region, major model parameters were localized and calibrated for the period of 1975–1980 and were then validated for 1981–1987. The R2 and NS validation indices were 0.70 and 0.65 for the monthly runoff and 0.67 and 0.61 for the sediment load, indicating that the model performance was acceptable. Between 2000 and 2015, the slope croplands were reduced by 39.9%, the forestlands increased by 90.2%, and the grasslands increased by 12.9%. These land‐use changes were simulated using SWAT to reduce the basin runoff by 13.8% and the sediment load by 50.7%. Spatial analyses using ArcGIS indicated that the simulated reduction in water yield due to cropland conversion to forestland was more obvious than that due to the conversion to grassland, but the reductions in the sediment yields were similar. The results suggest that the Grain‐for‐Green practice during this period was effective for preventing soil and water losses.
Bayesian Modeling of Temporal Coherence in Videos for Entity Discovery and Summarization

A video is understood by users in terms of entities present in it. Entity Discovery is the task of building appearance model for each entity (e.g., a person), and finding all its occurrences in the video. We represent a video as a sequence of tracklets, each spanning 10-20 frames, and associated with one entity. We pose Entity Discovery as tracklet clustering, and approach it by leveraging Temporal Coherence (TC): the property that temporally neighboring tracklets are likely to be associated with the same entity. Our major contributions are the first Bayesian nonparametric models for TC at tracklet-level. We extend Chinese Restaurant Process (CRP) to TC-CRP, and further to Temporally Coherent Chinese Restaurant Franchise (TC-CRF) to jointly model entities and temporal segments using mixture components and sparse distributions. For discovering persons in TV serial videos without meta-data like scripts, these methods show considerable improvement over state-of-the-art approaches to tracklet clustering in terms of clustering accuracy, cluster purity and entity coverage. The proposed methods can perform online tracklet clustering on streaming videos unlike existing approaches, and can automatically reject false tracklets. Finally we discuss entity-driven video summarization- where temporal segments of the video are selected based on the discovered entities, to create a semantically meaningful summary.
Streptococcus pneumoniae Colonization Disrupts the Microbial Community within the Upper Respiratory Tract of Aging Mice

ABSTRACT Nasopharyngeal colonization by the Gram-positive bacterium Streptococcus pneumoniae is a prerequisite for pneumonia and invasive pneumococcal diseases. Colonization is asymptomatic, involving dynamic and complex interplay between commensals, the host immune system, and environmental factors. The elderly are at an increased risk of developing pneumonia, which might be due to changes in the respiratory microbiota that would impact bacterial colonization and persistence within this niche. We hypothesized that the composition of the upper respiratory tract (URT) microbiota changes with age and subsequently can contribute to sustained colonization and inefficient clearance of S. pneumoniae. To test this, we used a mouse model of pneumococcal colonization to compare the composition of the URT microbiota in young, middle-aged, and old mice in the naive state and during the course of colonization using nasal pharyngeal washes. Sequencing of variable region 3 (V3) of the 16S rRNA gene was used to identify changes occurring with age and throughout the course of S. pneumoniae colonization. We discovered that age affects the composition of the URT microbiota and that colonization with S. pneumoniae is more disruptive of preexisting communities in older mice. We have further shown that host-pathogen interactions following S. pneumoniae colonization can impact the populations of resident microbes, including Staphylococcus and Haemophilus. Together, our findings indicate alterations to the URT microbiota could be detrimental to the elderly, resulting in increased colonization of S. pneumoniae and decreased efficiency in its clearance.
Zero-Cross Instantaneous State Setting for Control of a Bifurcating H-Bridge inverter

This paper studies stabilization of low-period unstable periodic orbits (UPOs) in a simplified model of a current mode H-bridge inverter. The switching of the inverter is controlled by pulse-width modulation signal depending on the sampled inductor current. The inverter can exhibit rich nonlinear phenomena including period doubling bifurcation and chaos. Our control method is realized by instantaneous opening of inductor at a zero-crossing moment of an objective UPO and can stabilize the UPO instantaneously as far as the UPO crosses zero in principle. Typical system operations can be confirmed by numerical experiments.
Dietary nutrient intake and antioxidant status in preeclamptic women

Background: Preeclampsia (PE) is the most common cause of maternal death in the world. Some studies showed that inadequate intake of foods rich in antioxidant leads to increase oxidative stress and adverting obstetrical outcomes. The aim of the present study was to investigate the relationship between antioxidant status and dietary nutrient intake in pregnant women with PE. Materials and Methods: This cross-sectional study was conducted among 55 pregnant women with PE admitted in the Obstetrics and Gynecology department of Shahid Beheshti Hospital in Isfahan, Iran. The subjects were interviewed about demographic data and dietary intakes by using a 168-items semi-quantitative food frequency questionnaire (FFQ). The total antioxidant capacity (TAC) of this serum was measured by using a double-antibody sandwich enzyme-linked immune-sorbent assay (ELISA). Nonparametric correlation statistics were used to meet assumptions of normality and equal variances. Results: Total antioxidant status was significantly higher in comparison with healthy pregnant women (which measured as pilot). Intake of vitamin E was below the dietary reference intakes, and was positively associated with serum TAC (r = 0.367, P = 0.003), but this correlation was significantly negative about dietary selenium. There wasn't any significant correlation between intake of vitamin C, β-carotene, riboflavin, copper and serum TAC. Conclusion : Our findings showed that intake of vitamin E was positively associated with serum TAC. Little support was found on a relationship between dietary intakes of other micronutrients and serum TAC. Further research is required to explore the relationships between maternal nutrient intake and antioxidant status in women with PE.
Biodiversity and biogeography of the atmosphere

The variation of life has predominantly been studied on land and in water, but this focus is changing. There is a resurging interest in the distribution of life in the atmosphere and the processes that underlie patterns in this distribution. Here, we review our current state of knowledge about the biodiversity and biogeography of the atmosphere, with an emphasis on micro-organisms, the numerically dominant forms of aerial life. We present evidence to suggest that the atmosphere is a habitat for micro-organisms, and not purely a conduit for terrestrial and aquatic life. Building on a rich history of research in terrestrial and aquatic systems, we explore biodiversity patterns that are likely to play an important role in the emerging field of air biogeography. We discuss the possibility of a more unified understanding of the biosphere, one that links knowledge about biodiversity and biogeography in the lithosphere, hydrosphere and atmosphere.
1-FFT amino acids involved in high DP inulin accumulation in Viguiera discolor

Fructans are important vacuolar reserve carbohydrates with drought, cold, ROS and general abiotic stress mediating properties. They occur in 15% of all flowering plants and are believed to display health benefits as a prebiotic and dietary fiber. Fructans are synthesized by specific fructosyltransferases and classified based on the linkage type between fructosyl units. Inulins, one of these fructan types with β(2-1) linkages, are elongated by fructan:fructan 1-fructosyltransferases (1-FFT) using a fructosyl unit from a donor inulin to elongate the acceptor inulin molecule. The sequence identity of the 1-FFT of Viguiera discolor (Vd) and Helianthus tuberosus (Ht) is 91% although these enzymes produce distinct fructans. The Vd 1-FFT produces high degree of polymerization (DP) inulins by preferring the elongation of long chain inulins, in contrast to the Ht 1-FFT which prefers small molecules (DP3 or 4) as acceptor. Since higher DP inulins have interesting properties for industrial, food and medical applications, we report here on the influence of two amino acids on the high DP inulin production capacity of the Vd 1-FFT. Introducing the M19F and H308T mutations in the active site of the Vd 1-FFT greatly reduces its capacity to produce high DP inulin molecules. Both amino acids can be considered important to this capacity, although the double mutation had a much higher impact than the single mutations.
Soy isoflavones in the prevention of menopausal bone loss and menopausal symptoms: a randomized, double-blind trial.

BACKGROUND Concerns regarding the risk of estrogen replacement have resulted in a significant increase in the use of soy products by menopausal women who, despite the lack of evidence of the efficacy of such products, seek alternatives to menopausal hormone therapy. Our goal was to determine the efficacy of soy isoflavone tablets in preventing bone loss and menopausal symptoms. METHODS The study design was a single-center, randomized, placebo-controlled, double-blind clinical trial conducted from July 1, 2004, through March 31, 2009. Women aged 45 to 60 years within 5 years of menopause and with a bone mineral density T score of -2.0 or higher in the lumbar spine or total hip were randomly assigned, in equal proportions, to receive daily soy isoflavone tablets, 200 mg, or placebo. The primary outcome was changes in bone mineral density in the lumbar spine, total hip, and femoral neck at the 2-year follow-up. Secondary outcomes included changes in menopausal symptoms, vaginal cytologic characteristics, N -telopeptide of type I bone collagen, lipids, and thyroid function. RESULTS After 2 years, no significant differences were found between the participants receiving soy tablets (n = 122) and those receiving placebo (n = 126) regarding changes in bone mineral density in the spine (-2.0% and -2.3%, respectively), the total hip (-1.2% and -1.4%, respectively), or the femoral neck (-2.2% and -2.1%, respectively). A significantly larger proportion of participants in the soy group experienced hot flashes and constipation compared with the control group. No significant differences were found between groups in other outcomes. CONCLUSIONS In this population, the daily administration of tablets containing 200 mg of soy isoflavones for 2 years did not prevent bone loss or menopausal symptoms. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00076050.
Basal Forebrain Cholinergic Deficits Reduce Glucose Metabolism and Function of Cholinergic and GABAergic Systems in the Cingulate Cortex

Purpose Reduced brain glucose metabolism and basal forebrain cholinergic neuron degeneration are common features of Alzheimer's disease and have been correlated with memory function. Although regions representing glucose hypometabolism in patients with Alzheimer's disease are targets of cholinergic basal forebrain neurons, the interaction between cholinergic denervation and glucose hypometabolism is still unclear. The aim of the present study was to evaluate glucose metabolism changes caused by cholinergic deficits. Materials and Methods We lesioned basal forebrain cholinergic neurons in rats using 192 immunoglobulin G-saporin. After 3 weeks, lesioned animals underwent water maze testing or were analyzed by 18F-2-fluoro-2-deoxyglucose positron emission tomography. Results During water maze probe testing, performance of the lesioned group decreased with respect to time spent in the target quadrant and platform zone. Cingulate cortex glucose metabolism in the lesioned group decreased, compared with the normal group. Additionally, acetylcholinesterase activity and glutamate decarboxylase 65/67 expression declined in the cingulate cortex. Conclusion Our results reveal that spatial memory impairment in animals with selective basal forebrain cholinergic neuron damage is associated with a functional decline in the GABAergic and cholinergic system associated with cingulate cortex glucose hypometabolism.
Cognitive Change in Heart Failure: A Systematic Review

Background—Cognitive impairment, highly prevalent in patients with heart failure (HF), increases risk for hospitalization and mortality. However, the course of cognitive change in HF is not well characterized. The purpose of this systematic review was to examine the available evidence longitudinal changes in cognitive function in patients with HF. Methods and Results—A literature search of several electronic databases was performed. Studies published from January 1, 1980, to September 30, 2012, that used validated measures to diagnose HF and assess cognitive function ≥2× in adults with HF were eligible for inclusion. Change in cognitive function was examined in the context of HF treatments applied (eg, medication initiation, left ventricular assist device implantation), length of follow-up, and comparison group. Fifteen studies met eligibility criteria. Significant decline in cognitive function was noted among patients with HF followed up for >1 year. Improvements in cognition were observed among patients with HF undergoing interventions to improve cardiac function (eg, heart transplantation) and among patients examined over short time periods (<1 year). Studies comparing patients' cognition over time with their own baseline tended to report improvements, whereas studies using a comparison group without HF tended to report declines or stability in cognition over time among patients with HF. Conclusions—Patients with HF are at increased risk for cognitive decline, but this risk seems to be modifiable with cardiac treatment. Further research is needed to identify the mechanisms that cause cognitive changes in HF.
Photo-enriched Documentation during Surgeries with Google Glass: An Exploratory Usability Study in a Department of Paediatric Surgery

Abstract Due to hygienic regulations and mobility requirements, medical professionals show great interest in wearable devices allowing for hands-free interaction and ubiquitous information access. Smartglasses like the prototype “Google Glass” have already been evaluated in pre-hospital as well as clinical medical care. Based on laboratory studies according to the reliability of voice and gesture recognition and field studies during four surgeries in the department of paediatric surgeries, we discuss usability and acceptance of smartglasses for photo-enriched documentation during surgeries. While technical limitations (e. g. poor camera quality) have to be overcome, usable solutions for human-smartglasses interaction by voice and gesture recognition seem to be possible midterm. Surgeons and other members of surgical teams are curious about smartglasses in their working environment. This can be a starting point for a wider use, if user interface and interaction design for smartglasses are further explored and developed in a user-centered process meeting their requirements. In this regard, transmodal consistency is recommended as a design principle for applications supporting multiple input and output modalities.
CHROMOSOME PULVERIZATION IN MICRONUCLEI INDUCED BY TRITIATED THYMIDINE

Cultures of a pseudodiploid cell line (Don) of Chinese hamster origin were exposed to varying doses of tritiated thymidine (TdR-3H) for relatively long periods of time. In addition to previously observed chromosomal aberrations) such as breaks and reunions, a substantial number of interphasic cells with micronuclei and of metaphases associated with pulverized chromosomes was found; both phenomena were dependent on exposure time to and concentration of TdR-3H. The former phenomenon appeared to result from the effects of the β-emissions originating in the TdR-3H. A possible interpretation for chromosome pulverization induction is presented, emphasizing the derivation of the pulverized material from micronuclei in a common cytoplasm with a metaphase nucleus. These observations further substantiate our previously advanced hypothesis regarding the essential role played by substances present in a mitotic cell in the induction of chromosome pulverization and nuclear membrane dissolution.