Miracle-dz/UniFAR-FTUs huggingface dataset:
A MEASUREMENT OF THE COSMIC MICROWAVE BACKGROUND B-MODE POLARIZATION POWER SPECTRUM AT SUB-DEGREE SCALES WITH POLARBEAR

We report a measurement of the B-mode polarization power spectrum in the cosmic microwave background (CMB) using the Polarbear experiment in Chile. The faint B-mode polarization signature carries information about the universe's entire history of gravitational structure formation, and the cosmic inflation that may have occurred in the very early universe. Our measurement covers the angular multipole range 500 < ℓ < 2100 and is based on observations of an effective sky area of 25 with 3. ′5 resolution at 150 GHz. On these angular scales, gravitational lensing of the CMB by intervening structure in the universe is expected to be the dominant source of B-mode polarization. Including both systematic and statistical uncertainties, the hypothesis of no B-mode polarization power from gravitational lensing is rejected at 97.2% confidence. The band powers are consistent with the standard cosmological model. Fitting a single lensing amplitude parameter ABB to the measured band powers, , where ABB = 1 is the fiducial wmap-9 ΛCDM value. In this expression, “stat” refers to the statistical uncertainty, “sys” to the systematic uncertainty associated with possible biases from the instrument and astrophysical foregrounds, and “multi” to the calibration uncertainties that have a multiplicative effect on the measured amplitude ABB.
Structured Sparsity Optimization With Non-Convex Surrogates of $\ell _{2,0}$ℓ2,0-Norm: A Unified Algorithmic Framework

In this paper, we present a general optimization framework that leverages structured sparsity to achieve superior recovery results. The traditional method for solving the structured sparse objectives based on l2,0-norm is to use the l2,1-norm as a convex surrogate. However, such an approximation often yields a large performance gap. To tackle this issue, we first provide a framework that allows for a wide range of surrogate functions (including non-convex surrogates), which exhibits better performance in harnessing structured sparsity. Moreover, we develop a fixed point algorithm that solves a key underlying non-convex structured sparse recovery optimization problem to global optimality with a guaranteed super-linear convergence rate. Building on this, we consider three specific applications, i.e., outlier pursuit, supervised feature selection, and structured dictionary learning, which can benefit from the proposed structured sparsity optimization framework. In each application, how the optimization problem can be formulated and thus be relaxed under a generic surrogate function is explained in detail. We conduct extensive experiments on both synthetic and real-world data and demonstrate the effectiveness and efficiency of the proposed framework.
Metabolomics implicate eicosanoids in severe functional mitral regurgitation

Secondary, or functional, mitral regurgitation (FMR) was recently recognized as a separate clinical entity, complicating heart failure with reduced ejection fraction (HFrEF) and entailing particularly poor outcome. Currently, there is a lack of targeted therapies for FMR due to the fact that pathomechanisms leading to FMR progression are incompletely understood. In this study, we sought to perform metabolomic profiling of HFrEF patients with severe FMR, comparing results to patients with no or mild FMR.
Analog of the spin-orbit induced anomalous Hall effect with quantized radiation

We demonstrate how the term describing the interaction between a single two-level atom and two cavity field modes may attain a Rashba form. As an outcome, cavity QED provides a testbed for studies of phenomena reminiscent of the spin-orbit induced anomalous Hall effect. The effective magnetic field, deriving from the non-Abelian gauge potentials rendered by the Rashba coupling, induces a transverse force acting on the phase space distributions. Thereby, the phase space distributions build up a transverse motion manifesting itself in spiral trajectories, rather than circular ones obtained for a zero magnetic field as one would acquire for the corresponding Abelian gauge potentials. Utilizing realistic experimental parameters, the phenomenon is numerically verified, ascertain that it should be realizable with current techniques.
Using Teamwork to Bridge the Adolescent and Young Adult Gap

PURPOSE: Individuals diagnosed with cancer age between 15 and 39 years (adolescents and young adults [AYAs]) have not seen improvement in survival compared with children or older adults; clinical trial accrual correlates with survival. Unique unmet needs among AYAs related to psychosocial support and fertility preservation (FP) are associated with health-related quality of life. METHODS: We enhanced existing structures and leveraged faculty/staff across pediatric/adult oncology to create novel teams focused on AYA (age 15-39 years) care at a single center, with minimal dedicated staff and no change to revenue streams. We aimed to influence domains shown to drive survival and health-related quality of life: clinical trial enrollment, physician/staff collaboration, psychosocial support, and FP. We captured metrics 3 months after patients presented to the institution and compared them before/after Program implementation using descriptive statistics. RESULTS: Among 139 AYAs (age 15-39 years) from the pre-Program era (January 2016-February 2019: adult, n = 79; pediatric, n = 60), and 279 from the post-Program era (February 2019-March 2022: adult, n = 215; pediatric, n = 64), there was no change in clinical trial enrollment(P ≥ .3), whereas there was an increase in the proportion of AYAs referred for supportive care and psychology (pediatric: P ≤ .02; adult: P ≤ .001); whose oncologists discussed FP (pediatric: 15% v 52%, P < .0001; adult: 37% v 50%, P = .0004); and undergoing FP consults (pediatric: 8% v39%, P < .0001; adult 23% v 38%, P = .02). CONCLUSION: This team-based framework has effected change in most targeted domains. To affect all domains and design optimal interventions, it is crucial to understand patient-level and facility-level barriers/facilitators to FP and clinical trial enrollment.
Beneficial effects of Spirulina platensis on mice testis damaged by silver nanoparticles

Silver nanoparticles (AgNPs) have been used widely in medical applications and various industries. Humans could be exposed to the risk of AgNPs toxicity through different routes. The current study aimed to investigate the role of Spirulina platensis (SP) against the side effects of AgNPs on mice testis. Adult male NMRI mice were divided into four groups: control group, SP group (300 mg/kg bwt), AgNPs (20 nm) group (500 mg/kg bwt), Co‐treated group (SP + AgNPs). The groups were treated orally for 35 days. Subsequently, epididymal sperm parameters, sperm DNA integrity, daily sperm production (DSP), sexual hormones level, malondialdehyde (MDA), total antioxidant capacity (TAC) and spermatogenesis indices were measured. In addition, the histopathology of testes was evaluated using tissue processing, haematoxylin–eosin staining and stereology techniques. A significant decrease in the number of spermatogenic cells, Leydig cells and sperm parameters was observed in the AgNPs treated group. Serum levels of testosterone and TAC were decreased significantly following AgNPs treatment. Also, MDA incremented in the serum of AgNPs treated mice. The stereological analysis revealed that AgNPs exposure induced histopathological changes in the seminiferous tubules, degeneration and dissociation of spermatogenic cells. In contrast, SP co‐administration significantly counteracted AgNPs reproductive toxicity impacts. SP co‐exposure caused an increase in spermatogenesis indices, TAC and also a decrease in MDA. SP improved the histopathological changes of testes tissue and spermatozoa abnormalities. In parallel, SP modulated levels of testosterone, FSH and LH. Spirulina platensis exhibited the protective potential by regulating oxidative stress against AgNPs‐induced reproductive toxicity. SP could be a candidate therapy against AgNPs reprotoxic impacts.
Socio-cognitive analysis of farmers’ water conservation behaviour: The case of the Kavar plain, Iran

Agricultural activities have a lot of effects on the environment so that water conservation measures help produce crops and consume water resources sustainably. The present research mainly aimed to explore farmers’ water conservation behaviour using the comprehensive action determination model (CADM). The research was conducted on the farmers in the Kavar plain in Fars province, Iran (N = 4000). The sample including 351 farmers was taken by the stratified random sampling technique. The measurement instrument was a questionnaire whose face and content validity was confirmed by a panel of experts. To check its reliability, a pilot study was conducted to calculate Cronbach's alpha and composite reliability (CR). The results showed that the indicators used to measure the research variables properly fitted the factor structure and the theoretical framework of the study. Based on the results, social norms (β = 0.26), personal norms (β = 0.22), attitude (β = 0.33), objective constraints (β = 0.38), and subjective constraints (β = 0.29) affect farmers’ water conservation intention positively and significantly. Also, farmers’ behaviour is influenced by their intention (β = 0.6), as well as their subjective (β = 0.73) and objective constraints (β = 0.58). It can be concluded that farmers’ water conservation behavior is shaped by a process that involves their normative process, habitual process, situation, and attitudes.
Seismic detection of a deep mantle discontinuity within Mars by InSight

Significance The depth and sharpness of a midmantle seismic discontinuity, associated with the phase transition from mineral olivine to its higher-pressure polymorphs, provide essential clues to understanding the temperature and composition of Martian mantle. Using data from NASA’s InSight mission, we examined five marsquakes located 3,400 to 4,400 km away from the InSight lander and observed triplications of the P and S waves that resulted from the interaction with a seismic discontinuity produced by the postolivine transition. Our observations indicate that the Martian mantle is more iron rich than Earth,and both planets have a similar potential temperature. Our geodynamic modeling further constrains the mantle composition and surface heat flow and indicates that the mantle was cold in the early Noachian.
Do differences in cell lines and methods used for calculation of IC50 values influence categorisation of drugs as P-glycoprotein substrates and inhibitors?

Abstract In vitro bidirectional assays are employed to determine whether a drug is a substrate and/or inhibitor of P-glycoprotein (P-gp) transport. Differences between cell lines and calculation methods can lead to variations in the determination of efflux ratios (ER) and IC50 values used to classify a drug as a P-gp substrate and inhibitor, respectively. Information was collected from the literature on ER and IC50 values with digoxin as the probe substrate using different cell lines and inhibition calculation methods. Predictive performance was evaluated by comparing [Igut]/IC50 ratios versus reported in vivo results. For known P-gp substrates, 50% of the drugs had their highest ER value in MDCK-MDR1 cells while 81% had their lowest ER value in Caco-2 cells. For 30 drugs with inhibition data, lower mean IC50 values were often observed with the Caco-2 cells and calculations based on ER. Based on the cut-off criteria of [Igut]/IC50 ≥ 10, there were no significant differences in positive or negative predictive values based on either cell line or calculation method for the drugs. Within this limited dataset, differences between cell lines or IC50 calculation methods do not seem to impact the prediction of in vivo P-gp inhibitor classification.
Vitamin B12, homocysteine, and folic acid in patients suffering from bipolar disorders: Relationship with suicide

Abstract Objectives Vitamin B12, folic acid, and homocysteine play a key role in ‘one-carbon metabolism’, involved in different brain processes. Altered levels have been reported in mood disorders (MDs), particularly in major depression (MDD), while the information in bipolar disorders (BDs) is limited. The present study aimed at assessing vitamin B12, homocysteine, and folic acid in 69 bipolar inpatients. Methods Twenty-seven patients were diagnosed with BDI, 15 BDII, 16 schizoaffective disorders, and 11 MDD, according to DSM-5 criteria. The clinical picture was assessed by the MINI, HRSD, YMRS, and CGI. The blood parameters were measured according to common clinical-chemical methods. Results Thirty-four patients had significantly lower vitamin B12, and 14 higher homocysteine levels than normative values. Folic acid levels were normal in the majority of the sample. Patients with a family history of suicide showed significantly lower levels of vitamin B12. Conclusions Our results underline the utility of assessing vitamin B12, homocysteine, and folic acid in patients with BD. Although other studies are necessary, the present findings that lower levels of vitamin B12 seem typical of patients with a family history of suicide independently from the phase of illness suggest that they might constitute a possible predictor of suicide.
Psychological sense of community, self-rated health and quality of life among older adults in Puerto Rico two years after Hurricane María

ABSTRACT Older adults who experience natural disasters are at risk for immediate and longer-term negative health outcomes and diminished quality of life (QOL), in part due to disruptions to social relationships and protections. We use a risk and resilience framework to examine the protective effects of psychological sense of community (PSOC) on self-rated health (SRH) and QOL for older adults in Puerto Rico 2 years after the devastation of Hurricane María in 2017. Between September 2019 and January 2020, we conducted face-to-face interviews with a nonprobability sample of 154 community-dwelling adults aged 60+ in Puerto Rico. Controlling for covariates, we used multivariate regression to examine the association of PSOC and key social risk factors (mental health, social isolation, and loneliness) with SRH and QOL. Higher levels of PSOC were significantly associated with better SRH and QOL. Regarding risks, worse mental health was significantly associated with lower QOL and SRH, loneliness was significantly related to worse QOL, and social isolation was significantly associated with better SRH and better QOL. PSOC was a protective factor for older adults, suggesting that prevention and intervention efforts should focus on building and sustaining older adults’ sense of community in the longer-term wake of natural disasters.
THE SUBLUMINOUS SUPERNOVA 2007qd: A MISSING LINK IN A FAMILY OF LOW-LUMINOSITY TYPE Ia SUPERNOVAE

We present multi-band photometry and multi-epoch spectroscopy of the peculiar Type Ia supernova (SN Ia) 2007qd, discovered by the SDSS-II Supernova Survey. It possesses physical properties intermediate to those of the peculiar SN 2002cx and the extremely low-luminosity SN 2008ha. Optical photometry indicates that it had an extraordinarily fast rise time of ≲10 days and a peak absolute B magnitude of −15.4 ± 0.2 at most, making it one of the most subluminous SN Ia ever observed. Follow-up spectroscopy of SN 2007qd near maximum brightness unambiguously shows the presence of intermediate-mass elements which are likely caused by carbon/oxygen nuclear burning. Near maximum brightness, SN 2007qd had a photospheric velocity of only 2800 km s−1, similar to that of SN 2008ha but about 4000 and 7000 km s−1 less than that of SN 2002cx and normal SN Ia, respectively. We show that the peak luminosities of SN 2002cx like objects are highly correlated with both their light-curve stretch and photospheric velocities. Its strong apparent connection to other SN 2002cx like events suggests that SN 2007qd is also a pure deflagration of a white dwarf, although other mechanisms cannot be ruled out. It may be a critical link between SN 2008ha and the other members of the SN 2002cx like class of objects.
The Therapeutic Role of Rho Kinase Inhibitor, Fasudil, on Pulmonary Hypertension; a Systematic Review and Meta-Analysis

Abstract Background Pulmonary hypertension (PH) is a pathophysiological disorder, which involves multiple clinical conditions such as the upregulation of the Rho/ROCK signaling pathway. On the other hand, fasudil as a Rho kinase inhibitor has been investigated in the treatment of PH in some clinical studies. Objectives The present systematic review and meta-analysis aimed to evaluate the human clinical trials regarding the efficacy of fasudil in the management of PH. Methods Databases were searched with pre-defined search terms, up to December 2021. Efficacy measures were such as mean pulmonary arterial pressure (mPAP), systolic PAP (sPAP), pulmonary vascular resistance (PVR), systolic vascular resistance (SVR) and cardiac index (CI). Results A total of 12 studies involving 575 PH patients were included in our research. Eight short-term trials and four mid-term trials were found (no clinical trials on the long-term effects). Short-term trials had a before-after study design and measuring pulmonary hemodynamic parameters’ intervention revealed a statistically significant improvement of mPAP, sPAP, PVR, SVR, and CI in the meta-analysis of five eligible studies. Three mid-term trials also revealed improvement in some pulmonary hemodynamic parameters with fasudil and in another mid-term trial, fasudil significantly decreased rehospitalization and mortality in PH patients. No serious adverse effects with fasudil were reported in these trials. Conclusion Fasudil therapy is efficacious and probably safe in the improvement of some hemodynamics in PH patients along short and mid-term periods. However, long-term randomized controlled trials comparing fasudil with placebo and other treatments are warranted for confirmation of these benefits.
Hippocampal involvement in working memory following refreshing

ABSTRACT Working memory (WM) and long-term memory (LTM) tests have both overlapping and distinct neurocognitive processes. Hippocampal activity in fMRI studies–a hallmark of LTM–also occurs on WM tasks, typically during encoding or retrieval and sometimes (albeit rarely) through ‘late-delay’ periods. The Synaptic Theory of WM suggests that ‘activity-silent’ synaptic weights retain temporary, WM-relevant codes without sustained, elevated activity. The hippocampus temporarily retains item-context bindings during WM-delays that are typically ‘silent’ to fMRI, probably via oscillatory patterns of informational connectivity among task-relevant regions of cortex. Advancing WM theory will require modeling this dynamic interplay, as in the ‘Dynamic Processing Model of WM.
Sex in protists: A new perspective on the reproduction mechanisms of trypanosomatids

Abstract The Protist kingdom individuals are the most ancestral representatives of eukaryotes. They have inhabited Earth since ancient times and are currently found in the most diverse environments presenting a great heterogeneity of life forms. The unicellular and multicellular algae, photosynthetic and heterotrophic organisms, as well as free-living and pathogenic protozoa represents the protist group. The evolution of sex is directly associated with the origin of eukaryotes being protists the earliest protagonists of sexual reproduction on earth. In eukaryotes, the recombination through genetic exchange is a ubiquitous mechanism that can be stimulated by DNA damage. Scientific evidences support the hypothesis that reactive oxygen species (ROS) induced DNA damage can promote sexual recombination in eukaryotes which might have been a decisive factor for the origin of sex. The fact that some recombination enzymes also participate in meiotic sex in modern eukaryotes reinforces the idea that sexual reproduction emerged as consequence of specific mechanisms to cope with mutations and alterations in genetic material. In this review we will discuss about origin of sex and different strategies of evolve sexual reproduction in some protists such that cause human diseases like malaria, toxoplasmosis, sleeping sickness, Chagas disease, and leishmaniasis.
Effect of a Toothpaste Containing Surface Pre-Reacted Glass-Ionomer Filler on the Remineralization of Artificial Carious Enamel Lesions in situ

This study evaluated the remineralizing effect of a toothpaste containing surface pre-reacted glass-ionomer (S-PRG) filler on demineralized enamel in situ. For this, 180 bovine enamel samples were demineralized by using a microcosm biofilm model for 3 days. Thereafter, the samples were randomly signed to 15 healthy volunteers and to 3 cross-over in situ phases corresponding to the following treatments: (1) toothpaste containing 1,500 ppm F as NaMFP (positive control, Colgate®Cavity Protection), (2) toothpaste containing 5% S-PRG filler (Shofu®), and (3) placebo toothpaste (negative control prepared by Shofu®). Four demineralized enamel blocks were fixed into each palatal appliance per phase. The volunteers wore the appliances for 5 days and were trained to brush their teeth 2 times for 2 min a day, while one drop of the toothpaste’s slurry (1:3) was dripped on each sample for the same period. The surface hardness and TMR analyses were done and analyzed by ANOVA/Tukey and t test (p < 0.05). S-PRG filler and Colgate® toothpastes were equally able to improve 2–2.5× enamel remineralization by the analysis of % surface hardness recovery. However, S-PRG toothpaste was the only one able to significantly improve ΔΔZ (the integrated mineral loss recovery: 1,489 ± 503 %vol.μm) compared to placebo (1,050 ± 467 %vol.μm), while Colgate® did not differ from placebo. No differences were seen between the groups with respect to ΔLD. S-PRG filler and Colgate® toothpastes show similar potential to remineralize the lesion surface. However, S-PRG toothpaste is better to recover mineral loss at the subsurface area.
SARS-CoV-2 Envelope Protein Forms Clustered Pentamers in Lipid Bilayers

The SARS-CoV-2 envelope (E) protein is a viroporin associated with the acute respiratory symptoms of COVID-19. E forms cation-selective ion channels that assemble in the lipid membrane of the endoplasmic reticulum Golgi intermediate compartment. The channel activity of E is linked to the inflammatory response of the host cell to the virus. Like many viroporins, E is thought to oligomerize with a well-defined stoichiometry. However, attempts to determine the E stoichiometry have led to inconclusive results and suggested mixtures of oligomers whose exact nature might vary with the detergent used. Here, we employ 19F solid-state nuclear magnetic resonance and the centerband-only detection of exchange (CODEX) technique to determine the oligomeric number of E’s transmembrane domain (ETM) in lipid bilayers. The CODEX equilibrium value, which corresponds to the inverse of the oligomeric number, indicates that ETM assembles into pentamers in lipid bilayers, without any detectable fraction of low-molecular-weight oligomers. Unexpectedly, at high peptide concentrations and in the presence of the lipid phosphatidylinositol, the CODEX data indicate that more than five 19F spins are within a detectable distance of about 2 nm, suggesting that the ETM pentamers cluster in the lipid bilayer. Monte Carlo simulations that take into account peptide–peptide and peptide–lipid interactions yielded pentamer clusters that reproduced the CODEX data. This supramolecular organization is likely important for E-mediated virus assembly and budding and for the channel function of the protein.