Miracle-dz/UniFAR-FTUs huggingface dataset:
The Molecular Weight Distribution of Succinoglycan Produced by Sinorhizobium meliloti Is Influenced by Specific Tyrosine Phosphorylation and ATPase Activity of the Cytoplasmic Domain of the ExoP Protein

ABSTRACT It is thought that in the gram-negative soil bacteriumSinorhizobium meliloti the protein ExoP is involved in biosynthesis of the acidic exopolysaccharide succinoglycan (EPS I). The amounts and compositions of EPS I produced by mutants expressing ExoP proteins characterized by specific amino acid substitutions in the C-terminal cytoplasmic domain were analyzed. The cytoplasmic domain of the ExoP protein was shown to have ATPase activity. Mutations in the highly conserved Walker A ATP-binding motif prevented ATPase activity of the ExoP protein. Phenotypically, these mutations resulted in much lower levels of succinoglycan which consisted only of monomers of the octasaccharide repeating unit. The ExoP protein has similarities to proteins with autophosphorylating protein tyrosine kinase activity. We found that ExoP was phosphorylated on tyrosine and that site-directed mutagenesis of specific tyrosine residues in the cytoplasmic domain of ExoP resulted in an altered ratio of low-molecular-weight succinoglycan to high-molecular-weight succinoglycan.
Progressive divergence of definitive haematopoietic stem cells from the endothelial compartment does not depend on contact with the foetal liver

The yolk sac and the para-aortic splanchnopleura/aorta-genital ridges-mesonephros (P-Sp/AGM) region are the main sites of haematopoietic activity in the mouse embryo at the pre-liver stage of development. By day 11.5 of gestation, the AGM region is capable of autonomous initiation and expansion of definitive haematopoietic stem cells (HSCs). By day 12.5, HSC activity in the AGM region is reduced whilst a second wave of HSCs begins to emerge in the yolk sac. We show here that HSCs emerging in both locations are marked by co-expression of the endothelial-specific marker VE-cadherin and the pan-leukocyte antigen CD45. Phenotypic characterisation using CD31, TIE2, FLK1, Ac-LDL receptors, and CD34 markers demonstrated significant similarities between this VE-cadherin+CD45+ `double-positive' population and endothelial cells suggesting a common origin for these cells. The double-positive fraction also expressed the stem cell markers Kit, Sca1 and AA4.1. Long-term transplantation experiments demonstrated that the double-positive population, which constituted less than 0.05% of the day 11.5 AGM region and the day 12.5 yolk sac, is highly enriched for HSCs. In vitro assays showed that this population is also enriched for myeloid progenitors. During foetal liver colonization, circulating HSCs remained within the VE-cadherin+ cell fraction, although their phenotypic similarity with endothelial cells became less prominent. Upon liver colonisation the majority of HSCs downregulated VE-cadherin, expression of which was completely lost in the adult bone marrow. Partial loss of VE-cadherin expression in HSCs can be observed extra hepatically in the advanced AGM region by E12.5. Similarly, the CD34+KIT+ population in the placenta, recently identified as a reservoir of HSCs, partly lose VE-cadherin expression by E12.5. By culturing isolated E11.5 AGM region and E12.5 yolk sac we show that the developmental switch from a `primary' VE-cadherin+CD45+ to a more `advanced' VE-cadherin-CD45+ phenotype does not require contact of HSCs with the liver and is probably a function of developmental time.
Language Models with GloVe Word Embeddings

Language Modeling is an important task in many Natural Language Processing (NLP) applications. These application include clustering, information retrieval, machine translation, spelling and grammatical errors correction. In general, a language model defined as a function that puts a probability measure over strings drawn from some vocabulary. In this work we consider a RNN based language model task, which aims at predicting the next n-th word in a sequence, given the previous n− 1 words. Put otherwise, finding the word with maximum value for P (wn|w1, ., wn−1) . The n parameter is the ContextWindowSize argument in the algorithm described further. To maximize the effectiveness and performance of the model we use word embeddings into a continuous vector space. The model of embedding we use is the GloVe [1] model, with dimensionality size equal to 300 or 50. We use both pre-trained1 on 42 billion tokens and 1.9 million vocabulary size, and specifically trained for this work vector models, which we trained on SIGIR-2015 and ICTIR-2015 conferences’ proceedings. The model itself is trained as a RNN, with internal GRU for memorizing the prior sequence of words. It was shown lately, that RNNs outperform most language modeling based tasks [2, 3] when tuned and trained correctly.
Trans-urban Networks of Learning, Mega Events and Policy Tourism

This paper argues for a rethinking of our understanding of what and where go into the ‘urban’ in the New Urban Politics (NUP). It contends that these issues have always been more complex, complicated and, most importantly, contested than has sometimes appeared to be the case in the literature. Using the example of one trans-urban policy learning network—that around the city of Manchester’s bids for the Olympic and Commonwealth Games—the paper makes the case for taking seriously the politics around comparison and referencing in making possible the NUP. It argues that there is a need to study the circuits, networks and webs in and through which urban knowledge and learning are constituted and moved around, and that often underpin the territorial outcomes that have been the traditional focus of scholars working on the NUP.
The New Standard for Performance of Intracranial Angioplasty and Stent Placement after Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis (SAMMPRIS) Trial

Percutaneous transluminal angioplasty and stent placement (PTAS) has become a treatment option for selected patients with symptomatic intracranial arterial stenosis. [1][1] The Stent Placement versus Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS)
School Choice and Ethnic Segregation

Since the 1980s, ethnic segregation has become a feature of the educational landscape in many European countries. The article explores how school choice has influenced this stratification in Dutch primary schools. In contrast to earlier research, the authors found that the ethnic composition of schools plays an important role in the school choice of parents. The study shows that native Dutch parents are significantly more interested in a match between their social and cultural background and the pupil composition of schools than ethnic minority parents. Minority parents prefer schools with a good reputation and that focus on their educational problems (e.g., learning proper Dutch). Both groups of parents generally reject predominately `non-White' schools. The authors also found other factors influencing the segregation patterns of schools (e.g., competition between schools and admission policies).
AILP: Abductive Inductive Logic Programming

Inductive Logic Programming (ILP) is often situated as a research area emerging at the intersection of Machine Learning and Logic Programming (LP). This paper makes the link more clear between ILP and LP, in particular, between ILP and Abductive Logic Programming (ALP), i e, LP extended with abductive reasoning. We formulate a generic framework for handling incomplete knowledge. This framework can be instantiated both to ALP and ILP approaches. By doing so more light is shed on the relationship between abduction and induction. As an example we consider the abductive procedure SLDNFA, and modify it into an inductive procedure which we call SLDNFAI.
Immunization with Recombinant Streptococcus pneumoniae Neuraminidase NanA Protects Chinchillas against Nasopharyngeal Colonization

ABSTRACT Immunization with recombinant S. pneumoniae neuraminidase NanA (rNanA) resulted in a significant reduction in pneumococcal colonization in the chinchilla model. The bacteria were eliminated from the nasopharynx 1 week earlier than that from the control cohort. Our data suggest that rNanA affords protection against pneumococcal nasopharyngeal colonization.
Reinsurance Trading in Lloyd’s of London: Balancing Conflicting-yet-Complementary Logics in Practice

Drawing on a year-long ethnographic study of reinsurance trading in Lloyd’s of London, this paper makes three contributions to current discussions of institutional complexity. First, we shift focus away from structural and relatively static organizational responses to institutional complexity and identify three balancing mechanisms - segmenting, bridging, and demarcating - which allow individuals to manage competing logics and their shifting salience within their everyday work. Second, we integrate these mechanisms in a theoretical model that explains how individuals can continually keep coexisting logics, and their tendencies to either blend or disconnect, in a state of dynamic tension which makes them conflicting-yet-complementary logics. Our model shows how actors are able to dynamically balance coexisting logics, maintaining the distinction between them, whilst also exploiting the benefits of their interdependence. Third, in contrast to most studies of newly formed hybrids and/or novel complexity our focus on a long-standing context of institutional complexity shows how institutional complexity can itself become institutionalized and routinely enacted within everyday practice.
Allogeneic Platelet Releasate Preparations Derived via a Novel Rapid Thrombin Activation Process Promote Rapid Growth and Increased BMP-2 and BMP-4 Expression in Human Adipose-Derived Stem Cells

The administration of human adipose-derived stem cells (ASCs) represents a promising regenerative therapy for the treatment of orthopedic injuries. While ASCs can be easily isolated from liposuction-derived adipose tissue, most clinical applications will likely require in vitro culture expansion of these cells using nonxenogeneic components. In this study, platelet releasate was generated using a novel rapid thrombin activation method (tPR). ASCs grown in media supplemented with tPR proliferated much faster than ASCs grown in media supplemented with 10% fetal bovine serum. The cells also retained the ability to differentiate along chondrogenic, adipogenic, and osteogenic lineages. The tPR cultured ASCs displayed elevated expression of BMP-4 (5.7 ± 0.97-fold increase) and BMP-2 (4.7 ± 1.3-fold increase) and decreased expression of PDGF-B (4.0 ± 1.4-fold decrease) and FGF-2 (33 ± 9.0-fold decrease). No significant changes in expression were seen with TGF-β and VEGF. This pattern of gene expression was consistent across different allogeneic tPR samples and different ASC lines. The use of allogeneic rapidly activated tPR to culture ASCs is associated with both an increased cell yield and a defined gene expression profile making it an attractive option for cell expansion prior to cell-based therapy for orthopedic applications.
Accelerated magnetic resonance thermometry in the presence of uncertainties

A model-based information theoretic approach is presented to perform the task of magnetic resonance (MR) thermal image reconstruction from a limited number of observed samples on k-space. The key idea of the proposed approach is to optimally detect samples of k-space that are information-rich with respect to a model of the thermal data acquisition. These highly informative k-space samples can then be used to refine the mathematical model and efficiently reconstruct the image. The information theoretic reconstruction was demonstrated retrospectively in data acquired during MR-guided laser induced thermal therapy (MRgLITT) procedures. The approach demonstrates that locations with high-information content with respect to a model-based reconstruction of MR thermometry may be quantitatively identified. These information-rich k-space locations are demonstrated to be useful as a guide for k-space undersampling techniques. The effect of interactively increasing the predicted number of data points used in the subsampled model-based reconstruction was quantified using the L2-norm of the distance between the subsampled and fully sampled reconstruction. Performance of the proposed approach was also compared with uniform rectilinear subsampling and variable-density Poisson disk subsampling techniques. The proposed subsampling scheme resulted in accurate reconstructions using a small fraction of k-space points, suggesting that the reconstruction technique may be useful in improving the efficiency of thermometry data temporal resolution.
Smart Water Distribution Management System Architecture Based on Internet of Things and Cloud Computing

The fast population growth needs to provide clean and affordable water that meet the human requirements. The water faces a problem in the future because of global climate change. An efficient water management and treatment is necessary to keep water quality and availability. Information and Communications Technologies (ICT) is combined with the Internet of thing (IoT) to facilitate water management and provide efficient operation of water resources, water distribution, and water quality. This paper presents an architecture for Smart Water Distribution System (SWDS) that corporate the IoT and Cloud Computing technologies with ICT. This architecture is designed for intermittent water supply while the previous works supposed a continuous water supply. No practical step is taken towards any phase in this paper, it contains all the theoretical requirements necessary to implement such system, especially in third world countries where the water supply is intermittent. A review of ICT-based water distribution management is provided and an overview of the most promising technologies related to them are thus explained.
Investigating the Familial Basis of Heightened Risk-Taking in Adolescents With Conduct Disorder and Their Unaffected Relatives

ABSTRACT Previous studies have demonstrated increased risk-taking in adolescents with Conduct Disorder (CD) compared with typically developing controls. Increased risk-taking may partly mediate the pathway from genetic or environmental risk to CD. We investigated the familial basis of risk-taking by examining whether the unaffected relatives of CD probands (n = 22) showed heightened risk-taking in a gambling task, in common with affected probands (n = 44). Adolescents with CD were more likely to select risky options than the typically developing controls (n = 37) and unaffected relatives. Our findings confirm the association between CD and increased risk-taking, but suggest that this decision-making style may not have a familial basis.
Speckle reducing for Sentinel-1 SAR data

Data provided by synthetic aperture radar (SAR) of Sentinel satellite can be useful for many applications. However, as for any SAR image, speckle noise is present in acquired images. Speckle properties are important for different operations of SAR image processing as filtering, edge detection, segmentation, classification. Thus, we first carry out preliminary analysis of speckle statistics and show that speckle PDF is quite close to Gaussian whilst noise is of practically multiplicative nature. Second, spatial correlation properties of speckle are analyzed. The study is performed in local DCT domain. This is done since then the obtained 2D spectrum is employed in image despeckling based on DCT. Peculiarities of several possible approaches to despeckling are discussed. Several examples for one component and dual polarization data are presented.
A hierarchical model for decentralized fighting of large scale urban fires

In this article we present a hierarchical model for planning and coordinating firefighting in situations such as RoboCup Rescue, where an urban earthquake is simulated. We show that a hierarchical approach brings leverage to the planning process. By using formal decision theoretic models, we also present a more formal analysis of the RoboCup Rescue domain. Finally we discuss how our model could be applied and treat further abstractions that may be necessary.
Assessment of Quality of life in Caregivers of Patients with Mental Disorder in Fatemie hospitals of Semnan city

Abstract Background : Families of patients with mental disorder endure remarkable hardship for coping with psychiatry symptom and they confront physical and emotional stresses. Maintaining and improving the quality of life is an important task for nurses. This study was designed to Determination of Quality of life in Caregivers of Patients with mental disorder in Fatemie hospitals of Semnan university of Medical Sciences. Method : A descriptive design was used. Samples consisted of Caregivers of Patients with mental disorder (Schizophrenia, Mania, Major Depressuon ( took part in this study. Data were gathered by questionnaire (Quality of life family version) in domains: physical, psychological, social and spiritual. Validity through content validity and reliability with a Cronbach's Alpha / was approved. Data were analyzed using SPSS software. Results : Most Caregivers of Patients with mental disorder are Female ( ) with a mean age of years and patient's wife ( ). The results of study showed that, majority of caregivers record at in physical ( . ), psychological ( ), social ( ) and in spiritual ( . ) as partly desirable level and the QOL scores of caregivers was . from . There was a significant association between quality of life and duration of caregiving (p = / ). Conclusion : copping with disease crisis and explore reasonable about further is more important. Nurses necessary to understand the necessity of family to support and give information. This issue improves Health and Well-being in families. Key words : Quality of life, caregivers, mental illness, Schizophrenia, Mania, Major Depressuon .
Cellular Physiology Cellular Physiology Cellular Physiology Cellular Physiology Cellular Physiology Nhe-1 Relocation outside Cholesterol-rich Membrane Microdomains Is Associated with Its Benzo[a]pyrene-related Apoptotic Function

Key Words NHE-1 • Cholesterol-rich-microdomains • Apoptosis • Benzo[a]pyrene • Calmodulin Abstract Background: Polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (B[a]P), are ubiquitous toxic environmental pollutants capable of inducing cell death. Intracellular pH plays a key role in the regulation of cell survival and death. Our previous works have demonstrated that intracellular alkalinization mediated by Na + /H + exchanger 1 (NHE-1) is a critical event involved in B[a]P-induced apoptosis. The aim of this study was to further elucidate the mechanisms of NHE-1 activation upon B[a]P exposure. Methods: We tested the effects of plasma membrane cholesterol enrichment or depletion on B[a]P-induced NHE-1 activation related to apoptosis. We isolated cholesterol-rich plasma membrane microdomains to assess NHE-1 sub-membrane location and immunoprecipitated NHE-1 from the different sub-membrane fractions obtained to examine NHE-1 protein interactions during B[a]P-induced apoptosis. Results: We found that NHE-1 is preferentially located in cholesterol-rich micro-domains and that B[a]P activates NHE-1 via its relocation and binding of calmodulin outside these specialized plasma membrane microstructures; these events are necessary for the execution of the apoptosis-related intracellular alkalinization. Conclusion: Plasma membrane location of NHE-1 affects its protein interactions and apoptotic function.
Detecting Bad SNPs from Illumina BeadChips Using Jeffreys Distance

Current microarray technologies are able to assay thousands of samples over million of SNPs simultaneously. Computational approaches have been developed to analyse a huge amount of data from microarray chips to understand sophisticated human genomes. The data from microarray chips might contain errors due to bad samples or bad SNPs. In this paper, we propose a method to detect bad SNPs from the probe intensities data of Illumina Beadchips. This approach measures the difference among results determined by three software Illuminus, GenoSNP and Gencall to detect the unstable SNPs. Experiment with SNP data in chromosome 20 of Kenyan people demonstrates the usefulness of our method. This approach reduces the number of SNPs that are needed to check manually. Furthermore, it has the ability in detecting bad SNPs that have not been recognized by other criteria.
The Psychology of conservatism

Contributors Foreword 1. The Concept of Conservatism 2. Conservatism, Authoritarianism and Related Variables a Review and Empirical Study 3. The Need for a New Approach to Attitude Measurement 4. Development and Evaluation of the C-Scale 5. The Factor Structure of the C-Scale 6. Measurement and Structure of Children's Attitudes 7. Religion, Racialism and Conservatism 8. Theological Conservatism 9. Conservatism and Superstitious Behaviour 10. Conservatism and Aesthetic Judgements 11. Conservatism and Response to Humour 12. The Temperamental Basis of Attitudes 13. Stimulus-Seeking and Conservatism 14. Conservatism Within Families: A Study of the Generation Gap 15. Conservatism, Psychiatry and Mental Distress 16. Attitudes to the Common Market: A Case Study in Conservatism 17. A Dynamic Theory of Conservatism
Full Implementation of Screening for Nutritional Risk and Dysphagia in an Acute Stroke Unit

Background and Purpose: In patients with acute stroke, undernutrition and aspiration pneumonia are associated with increased mortality and length of hospital stay. Formal screening for nutritional risk and dysphagia helps to ensure optimal nutritional management in all patients with stroke and to reduce the risk of aspiration in patients with dysphagia. We developed a national guideline for nutritional and dysphagia screening in acute stroke, which was introduced in our stroke unit on June 1, 2012. The primary objective was to audit adherence to the guideline and to achieve full implementation. Second, we assessed the prevalence of nutritional risk and dysphagia. Methods: We performed a chart review to assess performance of screening for nutritional risk and dysphagia in all patients with stroke hospitalized for ≥48 hours between June 1, 2012, and May 31, 2013. Next we applied a “clinical microsystems approach” with rapid improvement cycles and audits over a 6-month period to achieve full implementation. Results: The chart review showed that nutritional risk screening was performed in 65% and swallow testing in 91% of eligible patients (n = 185). Proactive implementation resulted in >95% patients screened (n = 79). The overall prevalence of nutritional risk was 29%, and 23% of the patients failed the initial swallow test. Conclusions: Proactive implementation is required to obtain high screening rates for nutritional risk and swallowing difficulties using validated screening tools. The proportion of patients at nutritional risk and the prevalence of dysphagia at initial swallow test were in the lower range of previous reports.