Miracle-dz/UniFAR-FTUs huggingface dataset:
A self-adaptive approach to efficiently manage energy and performance in tomorrow's heterogeneous computing systems

ICT adoption rate boomed during the last decades as well as the power consumption footprint that generates from those technologies. This footprint is expected to more than triple by 2020. Moreover, we are moving towards an on-demand computing scenario, characterized by varying workloads, constituted of diverse applications with different performance requirements, and criticality. A promising approach to address the challenges posed by this scenario is to better exploit specialized computing resources integrated in a heterogeneous system architecture (HSA) by taking advantage of their individual characteristics to optimize the performance/energy trade-off of the overall system. Better exploitation although comes with higher complexity. System architects need to take into account the efficiency of systems units, i.e. GPP(s) either alone or with a single family of accelerators (e.g., GPUs or FPGAs), as well as the applications workload, which often leads to inefficiency in their exploitation, and therefore in performance/energy. The work presented in this paper will address these limitations by exploiting self-adaptivity to allow the system to autonomously decide which specialized resource to exploit for a carbon footprint reduction, due to a more effective execution of the application, optimizing goals that the user can set (e.g., performance, energy, reliability).
Individual Human Brain Areas Can Be Identified from Their Characteristic Spectral Activation Fingerprints

The human brain can be parcellated into diverse anatomical areas. We investigated whether rhythmic brain activity in these areas is characteristic and can be used for automatic classification. To this end, resting-state MEG data of 22 healthy adults was analysed. Power spectra of 1-s long data segments for atlas-defined brain areas were clustered into spectral profiles (“fingerprints”), using k-means and Gaussian mixture (GM) modelling. We demonstrate that individual areas can be identified from these spectral profiles with high accuracy. Our results suggest that each brain area engages in different spectral modes that are characteristic for individual areas. Clustering of brain areas according to similarity of spectral profiles reveals well-known brain networks. Furthermore, we demonstrate task-specific modulations of auditory spectral profiles during auditory processing. These findings have important implications for the classification of regional spectral activity and allow for novel approaches in neuroimaging and neurostimulation in health and disease.
Constraint Solving by Narrowing in Combined Algebraic Domains

Narrowing is a way to integrate function evaluation and equality deenition into logic programming. Here we show how this can be combined with the constraint paradigm. We propose a solver for goals with constraints in theories deened by unconstrained equalities and rewrite rules with constraints expressed in an algebraic built-in structure. The narrowing method reduces the goal solving problem in the whole theory to rewriting and constraint solving in an adequate combined theory. The combined solver is obtained through the combination of a solver in the built-in structure and a solver for the unconstrained equalities. Suucient syntactic conditions are proposed to get a process that enumerates a complete set of solutions.
Auditory Distance Rendering Based on ICPD Control for Stereophonic 3D Audio System

In this letter, we propose a new auditory distance rendering (ADR) algorithm based on the interchannel phase difference (ICPD) control. In the conventional ICPD control, distance perception of the sound image is nonlinearly controlled, and directional localization of the sound image can be biased by changes of the interaural cues. These problems are caused by applying the frequency-independent ICPD without considering the acoustic transfer paths of the system setup. To solve these problems, first, the interaural cues of ear signals are analyzed by binaural auditory simulations. Then, stereophonic ADR filters are designed that produce ear signals with a linearly controlled interaural cross-correlation (IACC) and a consistent interaural level difference (IALD) for sophisticated distance perception under the given stereo setup. Subjective test results show that the proposed algorithm can provide better distance controllability than the conventional method with reduced lateralization blur of the sound image.
Phosphorylation and gene expression of p53 are not affected in human cells exposed to 2.1425 GHz band CW or W‐CDMA modulated radiation allocated to mobile radio base stations

A large‐scale in vitro study focusing on low‐level radiofrequency (RF) fields from mobile radio base stations employing the International Mobile Telecommunication 2000 (IMT‐2000) cellular system was conducted to test the hypothesis that modulated RF fields induce apoptosis or other cellular stress response that activate p53 or the p53‐signaling pathway. First, we evaluated the response of human cells to microwave exposure at a specific absorption rate (SAR) of 80 mW/kg, which corresponds to the limit of the average whole‐body SAR for general public exposure defined as a basic restriction by the International Commission on Non‐Ionizing Radiation Protection (ICNIRP) guidelines. Second, we investigated whether continuous wave (CW) and wideband code division multiple access (W‐CDMA) modulated signal RF fields at 2.1425 GHz induced apoptosis or any signs of stress. Human glioblastoma A172 cells were exposed to W‐CDMA radiation at SARs of 80, 250, and 800 mW/kg, and CW radiation at 80 mW/kg for 24 or 48 h. Human IMR‐90 fibroblasts from fetal lungs were exposed to both W‐CDMA and CW radiation at a SAR of 80 mW/kg for 28 h. Under the RF field exposure conditions described above, no significant differences in the percentage of apoptotic cells were observed between the test groups exposed to RF signals and the sham‐exposed negative controls, as evaluated by the Annexin V affinity assay. No significant differences in expression levels of phosphorylated p53 at serine 15 or total p53 were observed between the test groups and the negative controls by the bead‐based multiplex assay. Moreover, microarray hybridization and real‐time RT‐PCR analysis showed no noticeable differences in gene expression of the subsequent downstream targets of p53 signaling involved in apoptosis between the test groups and the negative controls. Our results confirm that exposure to low‐level RF signals up to 800 mW/kg does not induce p53‐dependent apoptosis, DNA damage, or other stress response in human cells. Bioelectromagnetics 27:494–504, 2006. © 2006 Wiley‐Liss, Inc.
Wavelet-demodulation-method based out of step detection and damping estimation in Japan campus warns

Some previous research based on Fast Fourier Transform (FFT) estimated the damping ratio and frequency oscillation from Eigen value of the matrix associated to a Single Machine Infinite Bus (SMIB) model. Damping constant can be calculated for every 20 minutes cycles. However, it failed to explain how to calculate the damping ratio without associating the system to a SMIB Model. Furthermore, there was no way to verify the validity of the analysis since no network parameters could be included in the calculation. This paper promotes a novel approach in analyzing Phasor Measurement Unit (PMU) data to identify out of step phenomena and the calculation of damping ratio by applying a Continuous Wavelet Transform (CWT) algorithm. A linear regression method is performed to extract the damping ratio from the wave skeleton. The validity of the method is verified by comparing the calculated and real data from mathematically generated signals with known parameters.
Review: healthy kidney donors may have a long-term increase in blood pressure beyond that associated with normal aging.

M e t h o d s Data sources: MEDLINE, EMBASE/ Excerpta Medica (1966 to November 2005), Science Citation Index, “Related Articles” on PubMed, primary study authors, and reference lists. Study selection and assessment: Studies in any language that assessed BP ≥ 1 year after kidney donation in healthy, normotensive adults. 48 studies (n = 5145 donors, mean age 41 y, 58% women) met the selection criteria, with a median 6 years (range 1 to 25 y) of follow-up. 23% of studies were prospective. Overall, 31% of donors were lost to follow-up. 10 studies (n = 1168 donors) included an appropriate comparison group and were the focus of the meta-analysis. Outcomes: Systolic and diastolic BP, and hypertension (variably defined).
Characterization of the impact of sets of scientific papers: The Garfield (impact) factor

The Garfield (Impact) Factor (GF) is one of the most frequently used scientometric indicators. In the present article it is shown that the main factors determining the value of the mean GF representing a set of journals are the number of articles published recently (articles referencing) related to those published in a previous time period (articles to be referenced) and the mean number of references in journal papers referring to the time period selected. It has been proved further that GF corresponds to the mean chance for citedness of journal papers. A new indicator, Specific Impact Contribution (SIC), is introduced, which characterizes the contribution of a subset of articles or a journal to the total impact of the respective articles or journals. The SIC index relates the share of a journal in citations divided by that in publications within a set of papers or journals appropriately selected. It is shown, however, that the normalized GFs of journals and the normalized SIC indicators are identical measures within any set of journals selected. It may be stated therefore that Garfield Factors of journals (calculated correctly) are appropriate scientometric measures for characterizing the relative international eminence of journals within a set of journals appropriately selected. It is demonstrated further that SIC indicators (and so GF indexes) correspond to the (number of citations per paper) indicators generally used, within the same set of papers.
Mechanosensory Gating of Proprioceptor Input to Modulatory Projection Neurons

Sensorimotor gating commonly occurs at sensory neuron synapses onto motor circuit neurons and motor neurons. Here, using the crab stomatogastric nervous system, we show that sensorimotor gating also occurs at the level of the projection neurons that activate motor circuits. We compared the influence of the gastro-pyloric receptor (GPR) muscle stretch-sensitive neuron on two projection neurons, modulatory commissural neuron 1 (MCN1) and commissural projection neuron 2 (CPN2), with and without a preceding activation of the mechanosensory ventral cardiac neurons (VCNs). MCN1 and CPN2 project from the paired commissural ganglia (CoGs) to the stomatogastric ganglion (STG), where they activate the gastric mill (chewing) motor circuit. When stimulated separately, the GPR and VCN neurons each elicit the gastric mill rhythm by coactivating MCN1 and CPN2. When GPR is instead stimulated during the VCN-gastric mill rhythm, it slows this rhythm. This effect results from a second GPR synapse onto MCN1 that presynaptically inhibits its STG terminals. Here, we show that, during the VCN-triggered rhythm, the GPR excitation of MCN1 and CPN2 in the CoGs is gated out, leaving only its influence in the STG. This gating effect appears to occur within the CoG and does not result from a ceiling effect on projection neuron firing frequency. Additionally, this gating action enables GPR to either activate rhythmic motor activity or act as a phasic sensorimotor feedback system. These results also indicate that the site of sensorimotor gating can occur at the level of the projection neurons that activate a motor circuit.
Oil spill detection using microwave images

Oil pollution is the major environmental concern in the world. It is important to detect oil spill and take necessary step to prevent pollution in marine ecosystem. Among several satellite, SAR can provide high resolution images with wide area coverage, day and night, and all weather capabilities. This paper presents anisotropic diffusion filtering and morphological levelling method for image simplification like denoising of SAR image and edge detection, this is one of the successful method for denoising of SAR image. Geometric level set segmentation is used to detect oil spill from SAR images.
Non-invasive ventilation in acute exacerbations of chronic obstructive pulmonary disease: long term survival and predictors of in-hospital outcome

BACKGROUND Non-invasive ventilation (NIV) reduces the need for intubation and the mortality associated with an exacerbation of chronic obstructive pulmonary disease (COPD). This study aimed to identify factors that could be used to stratify patients according to their risk of requiring invasive mechanical ventilation. The second aim was to determine the long term survival of patients treated with and without NIV. METHODS In this prospective multicentre randomised controlled trial 118 patients were allocated to standard treatment and 118 to NIV between November 1996 and September 1998. Arterial blood gas tensions and respiratory rate were recorded at enrolment and after 1 and 4 hours. Prognostic factors were identified using logistic regression analysis. All patients were followed until death or 1 January 1999. RESULTS At enrolment the H+ concentration (OR 1.22 per nmol/l, 95% CI 1.09 to 1.37, p<0.01) and Paco 2 (OR 1.14 per kPa, 95% CI 1.14 to 1.81, p<0.01) were associated with treatment failure. Allocation to NIV was protective (OR 0.39, 95% CI 0.19 to 0.80). After 4 hours of treatment improvement in acidosis (OR 0.89 per nmol/l, 95% CI 0.82 to 0.97, p<0.01) and fall in respiratory rate (OR 0.92 per breaths/min, 95% CI 0.84 to 0.99, p=0.04) were associated with success. Median length of survival was 16.8 months in those treated with NIV and 13.4 months in those receiving standard treatment (p=0.12). The trend in improved survival was attributable to prevention of death during the index admission. CONCLUSION Initial pH and hypercapnia can be used to stratify groups of patients according to their risk of needing intubation. NIV reduces this risk and progress should be monitored using change in respiratory rate and pH. The long term survival after NIV is sufficiently good to render treatment appropriate.
IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis

Background Myelodysplastic syndromes are a heterogeneous group of hematopoietic stem cell disorders with a high propensity to transform into acute myeloid leukemia. Heterozygous missense mutations in IDH1 at position R132 and in IDH2 at positions R140 and R172 have recently been reported in acute myeloid leukemia. However, little is known about the incidence and prognostic impact of IDH1 and IDH2 mutations in myelodysplastic syndromes. Design and Methods We examined 193 patients with myelodysplastic syndromes and 53 patients with acute myeloid leukemia arising from myelodysplastic syndromes for mutations in IDH1 (R132), IDH2 (R172 and R140), and NPM1 by direct sequencing. Results We found that mutations in IDH1 occurred with a frequency of 3.6% in myelodysplastic syndromes (7 mutations in 193 patients) and 7.5% in acute myeloid leukemia following myelodysplastic syndromes (4 mutations in 53 patients). Three mutations in codon R140 of IDH2 and one mutation in codon R172 were found in patients with acute myeloid leukemia following myelodysplastic syndromes (7.5%). No IDH2 R140 or R172 mutations were identified in patients with myelodysplastic syndromes. The presence of IDH1 mutations was associated with a shorter overall survival (HR 3.20; 95% CI 1.47–6.99) and a higher rate of transformation into acute myeloid leukemia (67% versus 28%, P=0.04). In multivariate analysis when considering karyotype, transfusion dependence and International Prognostic Scoring System score, IDH1 mutations remained an independent prognostic marker in myelodysplastic syndromes (HR 3.57; 95% CI 1.59–8.02; P=0.002). Conclusions These results suggest that IDH1 mutations are recurrent molecular aberrations in patients with myelodysplastic syndromes, and may become useful as a poor risk marker in these patients. These findings await validation in prospective trials.
Cerebrovascular Consequences of Obstructive Sleep Apnea

Obstructive sleep apnea (OSA) is an independent risk factor for stroke. However, little is known about how OSA affects the cerebral circulation. The goal of this project was to test the following hypothesis: Chronic exposure to apnea produces hypertension and alters nitric oxide (NO) mediated dilation in cerebral arteries. For these studies, we developed a novel model of OSA in rats. Airway obstruction was induced by a chronically implanted, inflatable endotracheal obstruction device. We induced 30 apneas (8 sec duration each)/hr during 8 hrs of the sleep cycle in free‐ranging rats. Apnea caused significant alterations in blood gasses [baseline vs. end apnea‐ pO2 (mmHg): 127 ± 2 vs. 67 ± 2; pCO2 (mmHg): 43 ± 1 vs. 51 ± 1; and pH: 7.46 ± 0.002 vs. 7.38 ± 0.01; n=5, p≤0.003]. Apnea decreased hemoglobin O2 saturation by 12 ± 1% (n=5, p=0.001 vs. Sham) and produced exaggerated negative airway pressures (−16 ± 0.7 mmHg; n=7, p<0.001 vs. Sham). Two weeks of apnea produced a 24‐hr mean blood pressure (BP) pattern similar to non‐dipping hypertensives (i.e. ‐ <10% BP dip during the sleep phase). After one month of apnea, NO‐mediated dilations to ATP in isolated cerebral arteries were attenuated by 20 ± 2% (n=4, p<0.02 vs. Sham). Using a novel model of OSA, which recapitulates OSA in humans, we demonstrate that endothelial dysfunction occurs by one month, likely increasing the vulnerability of the brain during stroke.
You're one in a googol: optimizing genes for protein expression

A vast number of different nucleic acid sequences can all be translated by the genetic code into the same amino acid sequence. These sequences are not all equally useful however; the exact sequence chosen can have profound effects on the expression of the encoded protein. Despite the importance of protein-coding sequences, there has been little systematic study to identify parameters that affect expression. This is probably because protein expression has largely been tackled on an ad hoc basis in many independent projects: once a sequence has been obtained that yields adequate expression for that project, there is little incentive to continue work on the problem. Synthetic biology may now provide the impetus to transform protein expression folklore into design principles, so that DNA sequences may easily be designed to express any protein in any system. In this review, we offer a brief survey of the literature, outline the major challenges in interpreting existing data and constructing robust design algorithms, and propose a way to proceed towards the goal of rational sequence engineering.
Complete Genome Sequence of Magnetospirillum sp. ME-1, a Novel Magnetotactic Bacterium Isolated from East Lake, Wuhan, China

ABSTRACT A novel spiral magnetotactic bacterium, Magnetospirillum sp. ME-1, was isolated from East Lake in China. Here we report the complete genome of ME-1, which contains a 4,551,873-bp circular chromosome and a 5,222-bp circular plasmid. The magnetosome biogenesis-specific genes are located in a 97,664-bp magnetosome genomic island.
A game-theoretic approach for minimizing security risks in the Internet-of-Things

In the Internet-of-Things (IoT), users might share part of their data with different IoT prosumers, which offer applications or services. Within this open environment, the existence of an adversary introduces security risks. These can be related, for instance, to the theft of user data, and they vary depending on the security controls that each IoT prosumer has put in place. To minimize such risks, users might seek an “optimal” set of prosumers. However, assuming the adversary has the same information as the users about the existing security measures, he can then devise which prosumers will be preferable (e.g., with the highest security levels) and attack them more intensively. This paper proposes a decision-support approach that minimizes security risks in the above scenario. We propose a non-cooperative, two-player game entitled Prosumers Selection Game (PSG). The Nash Equilibria of PSG determine subsets of prosumers that optimize users' payoffs. We refer to any game solution as the Nash Prosumers Selection (NPS), which is a vector of probabilities over subsets of prosumers. We show that when using NPS, a user faces the least expected damages. Additionally, we show that according to NPS every prosumer, even the least secure one, is selected with some non-zero probability. We have also performed simulations to compare NPS against two different heuristic selection algorithms. The former is proven to be approximately 38% more effective in terms of security-risk mitigation.
A two-stage sensitivity analysis for parameter identification and calibration of a physically-based distributed model in a river basin

ABSTRACT Hydrological models demand large numbers of input parameters, which are to be optimally identified for better simulation of various hydrological processes. Identifying the most relevant parameters and their values using efficient sensitivity analysis methods helps to better understand model performance. In this study, the physically-based distributed model SHETRAN is used for hydrological simulation on the Netravathi River Basin in south India and the most important parameters are identified using the Morris screening method. Further, the influence of a particular model parameter on streamflow is quantified using local sensitivity analysis and optimal parameters are obtained for calibration of the SHETRAN model. The results demonstrate the capability of two-stage sensitivity analysis, combining qualitative and quantitative methods in the initial screening-out of insignificant model parameters, identifying parameter interactions and quantifying the contribution of each model parameter to the streamflow. The results of the sensitivity analysis simplified the calibration procedure of SHETRAN for the study area.
Diagnostic criteria used in studies of reflex sympathetic dystrophy

ObjectiveAssessment of the diagnostic criteria of reflex sympathetic dystrophy (RSD) and evaluation of the impact of the introduction of the diagnostic criteria of complex regional pain syndrome (CRPS) on the international application of diagnostic criteria of RSD. MethodsRandomized controlled trials and clinical investigations, published between January 1980 and June 2000, were evaluated with regard to the applied diagnostic criteria of RSD. ResultsOne hundred seven studies were identified. Thirty-four of these studies were excluded because of inadequate reporting of diagnostic criteria. The 73 included studies were not homogeneous with regard to the diagnostic criteria because they applied many different aspects of sensory and autonomic features. Only 12% of the studies considered the presence of motor features, mostly vaguely described, as mandatory for the diagnosis RSD. Although 10 of the 23 studies published since the introduction of CRPS have applied this term, only 3 used the exact criteria without additions or other modifications. ConclusionDiagnostic criteria sets of RSD focus on many different aspects of sensory and autonomic features that generally are described vaguely. This has not changed since the introduction of the CPRS criteria. These findings question whether the current criteria adequately define RSD.