Miracle-dz/UniFAR-FTUs huggingface dataset:
Economic indices for the North Pacific groundfish fisheries : calculation and visualization

This report details the methods used to create indices for monitoring economic performance in the Alaskan North Pacific Groundfish Fisheries published in the annual Economic Status of the Groundfish Fisheries off Alaska report. The intuition and interpretation of the indices is discussed followed by a review of the formal literature on the technical properties of indices and the methods for their construction. A decomposition of the Fisher Index is derived which relates sub-indices to a larger aggregate index. The derivations are extended to chained indices over time. A case study of the Gulf of Alaska shoreside groundfish fishery is used to show how the indices and supporting statistics can be graphically displayed to efficiently characterize significant amounts of data across different dimensions of economic markets.
Using PCA to improve evolutionary cellular automata algorithms

The difficulty of designing cellular automatons' transition rules to perform a particular problem has severely limited their applications. Using a genetic algorithm to evolve cellular automata for fining these rules, is a good solution. Conventional evolutionary methods use random test configurations for calculating fitness values of each transition rule. In this paper, we use Principal Component Analysis to build better test configurations. By emphasizing on diversity between test instances in a test plan, we can evaluate rules better and faster as well as increase their accuracy. In this paper, we propose two models based on this idea. Experimental results on density classification and synchronization tasks prove that our methods are more efficient than the conventional one.
Dienogest in long-term treatment of endometriosis

Endometriosis is a chronic disease primarily affecting women of childbearing age, in which endometriotic lesions form outside the uterus, typically leading to painful symptoms, fatigue, and infertility. The symptoms of endometriosis may cause significant impairment in quality of life and represent a substantial economic burden to patients, families, and society. There is no cure for endometriosis; management consists of alleviating pain and other symptoms, reducing endometriotic lesions, and improving quality of life. Recurrence after surgical intervention is common, while the clinical evidence to support the efficacy and safety of many medications currently used in endometriosis is limited. Dienogest is an oral progestin that has been investigated extensively in the treatment of endometriosis in two clinical programs performed in Europe and Japan, including dose-ranging, placebo-controlled, active comparator-controlled, and long-term (up to 65 weeks) studies. These studies demonstrated that dienogest 2 mg daily effectively alleviates the painful symptoms of endometriosis, reduces endometriotic lesions, and improves indices of quality of life. Dienogest showed a favorable safety and tolerability profile in these studies, with predictable adverse effects, high rates of patient compliance, and low withdrawal rates. This review article describes the clinical trial evidence that characterizes the efficacy and safety of dienogest in endometriosis, including two studies characterizing dienogest in long-term use. The relevance of these findings to the management of endometriosis in clinical practice is discussed.
Evaluating and Combining Approaches to Selectional Preference Acquisition

Previous work on the induction of selectional preferences has been mainly carried out for English and has concentrated almost exclusively on verbs and their direct objects. In this paper, we focus on class-based models of selectional preferences for German verbs and take into account not only direct objects, but also subjects and prepositional complements. We evaluate model performance against human judgments and show that there is no single method that overall performs best. We explore a variety of parametrizations for our models and demonstrate that model combination enhances agreement with human ratings.
Designing for the Third Hand: Empowering Older Adults with Cognitive Impairment through Creating and Sharing

Cognitive impairment is sometimes viewed as a deficit limiting an individual's ability to participate fully in society. Art therapy, in contrast, is a context in which older adults with cognitive impairments (e.g., dementia, aphasia) are positioned as capable, competent, and engaged through the act of creating and sharing artwork. We draw on the concept of the "Third Hand," a practice in art therapy in which the therapist attunes to and enables the desires of the client during interaction. We use this concept to understand how to empower creative work and sharing among older adults with cognitive impairments. We introduce an interactive frame prototype to explore new opportunities for sharing and supporting interaction between these older adults and their therapist. We conclude with a discussion of what designing for the Third Hand means to HCI, including how this metaphor provides a model of empathy and empowerment in design for this population.
Petrogenesis of pillow basalts in West Junggar, NW China: Constraints from geochronology, geochemistry, and Sr–Nd–Pb isotopes

West Junggar is located at the southwest margin of the Central Asian Orogenic Belt and includes Silurian pillow basalts of the Mayilashan Formation. The petrogenesis and tectonic setting of these pillow basalts are important for the understanding of the tectonic evolution and metallogeny of the West Junggar area. This paper presents geochronological, geochemical, and whole‐rock Sr–Nd–Pb isotope data from the pillow basalts of the Mayilashan Formation. Zircon LA‐ICP‐MS U–Pb dating of a pillow basalt, which is in conformable contact with the chert, suggests that they were erupted at 437.2 ± 2.2 Ma marking the timing of generation of these rocks as Middle Silurian. Geochemically, all the pillow basalts bear the signature of ocean island basalt (OIB), and are characterized by alkaline affinity with high concentrations of TiO2 (3.28–4.12 wt.%), LILE and LREE enrichment and HREE depletion ((La/Yb)N = 5.5–7.3), with very weak Eu anomalies (Eu/Eu* = 0.96–1.06), and no obvious Nb, Ta, or Ti negative anomalies. Their Sr–Nd–Pb isotopic compositions ((87Sr/86Sr)I = 0.7037–0.7051, εNd(t) = 1.9–2.9, 206Pb/204Pbi = 17.74–18.22, 207Pb/204Pbi = 15.48–15.52, and 208Pb/204Pbi = 36.49–37.86) show Dupal‐like isotopic signature of ophiolites in the southern Paleo‐Asian Ocean. These characteristics indicate that the magmas were derived from a deep OIB reservoir, that is, a depleted but slightly heterogeneous asthenospheric mantle source with ~5–15% partial melting of garnet and spinel lherzolite. Our obtained results, in conjunction with previous published data, allow us to suggest that the alkaline pillow basalts formed in a seamount within an intraoceanic setting, where a larger number of seamounts with different ages occurred in the Paleo‐Asian Ocean.
Molecular Basis of Live-Attenuated Influenza Virus

Human influenza is a seasonal disease associated with significant morbidity and mortality. The most effective means for controlling infection and thereby reducing morbidity and mortality is vaccination with a three inactivated influenza virus strains mixture, or by intranasal administration of a group of three different live attenuated influenza vaccine strains. Comparing to the inactivated vaccine, the attenuated live viruses allow better elicitation of a long-lasting and broader immune (humoral and cellular) response that represents a naturally occurring transient infection. The cold-adapted (ca) influenza A/AA/6/60 (H2N2) (AA ca) virus is the backbone for the live attenuated trivalent seasonal influenza vaccine licensed in the United States. Similarly, the influenza A components of live-attenuated vaccines used in Russia have been prepared as reassortants of the cold-adapted (ca) H2N2 viruses, A/Leningrad/134/17/57-ca (Len/17) and A/Leningrad/134/47/57-ca (Len/47) along with virulent epidemic strains. However, the mechanism of temperature-sensitive attenuation is largely elusive. To understand how modification at genetic level of influenza virus would result in attenuation of human influenza virus A/PR/8/34 (H1N1,A/PR8), we investigated the involvement of key mutations in the PB1 and/or PB2 genes in attenuation of influenza virus in vitro and in vivo. We have demonstrated that a few of residues in PB1 and PB2 are critical for the phenotypes of live attenuated, temperature sensitive influenza viruses by minigenome assay and real-time PCR. The information of these mutation loci could be used for elucidation of mechanism of temperature-sensitive attenuation and as a new strategy for influenza vaccine development.
A review of the current state of knowledge of proglacial hydrogeology in the Cordillera Blanca, Peru

The rapidly melting glaciers of Peru are posing new risks to regional dry season water supplies, and this is evident in the Cordillera Blanca, the mountain range with the world's largest concentration of tropical glaciers. Permanent ice loss is causing reductions to dry season streamflow, which is coupled with shifting demands and control over water access and entitlements in the region. A full evaluation of hydrologic inputs is required to inform future water management in the relative absence of glaciers. Over the last decade, new studies have shown groundwater to be a significant component of the regional water budget during the dry season, and it cannot be ignored when accounting for water quality and quantity downstream of the Cordillera Blanca's alpine catchments. Distinctive common features of the Cordillera Blanca's proglacial catchments are sediment‐filled valleys that were once under proglacial lake conditions. The combination of lake sediments with other alpine depositional features results in storage and interseasonal release of groundwater that comprises up to 80% of the valley's streamflow during the driest months of the year. We summarize the emerging understanding of hydrogeologic processes in proglacial headwater systems of the region's principal river, the Rio Santa, and make suggestions for future research that will more clearly characterize the spatial distribution of stored groundwater within the mountain range. As glaciers continue to recede, differences in aquifer thickness and groundwater residence time between alpine catchments in the region will increasingly control dry season water availability at the local and basin scale.
Cellular Regulation of RGS Proteins: Modulators and Integrators of G Protein Signaling

Regulators of G protein signaling (RGS) and RGS-like proteins are a family (>30 members) of highly diverse, multifunctional signaling proteins that bind directly to activated Gα subunits. Family members are defined by a shared RGS domain, which is responsible for Gα binding and markedly stimulates the GTPase activity of Gα subunits leading to their deactivation and termination of downstream signals. Although much has been learned in recent years about the biochemistry of RGS/Gα interactions, considerably less is known about the broader cellular roles and regulation of RGS proteins. Recent findings indicate that cellular mechanisms such as covalent modification, alternative gene splicing, and protein processing can dictate the activity and subcellular localization of RGS proteins. Many family members also directly link G proteins to a growing list of signaling proteins with diverse cellular roles. New findings indicate that RGS proteins act not as dedicated inhibitors but, rather, as tightly regulated modulators and integrators of G protein signaling. In some cases, RGS proteins modulate the lifetime and kinetics of both slow-acting (e.g., Ca2+ oscillations) and fast-acting (e.g., ion conductances, phototransduction) signaling responses. In other cases, RGS proteins integrate G proteins with signaling pathways linked to such diverse cellular responses as cell growth and differentiation, cell motility, and intracellular trafficking. These and other recent studies with animal model systems indicate that RGS proteins play important roles in both physiology and disease. Recognition of the central functions these proteins play in vital cellular processes has focused our attention on RGS proteins as exciting new candidates for therapeutic intervention and drug development.
Sparse Matrix-Matrix Multiplication for Modern Architectures

Sparse matrix-matrix multiplication (SPMM) is an important kernel in high performance computing that is heavily used in the graph analytics as well as multigrid linear solvers. Because of its highly sparse structure, it is usually difficult to exploit the parallelism in the modern shared memory architectures. Although there have been various work studying shared memory parallelism of SPMM, some points are usually overlooked, such as the memory usage of the SPMM kernels. Since SPMM is a service-kernel, it is important to respect the memory usage of the calling application in order not to interfere with its execution. In this work, we study memory-efficient scalable shared memory parallel SPMM methods. We study graph compression techniques that reduce the size of the matrices, and allow faster computations. Our preliminary results show that we obtain upto 40% speedups w.r. t SPMM implementation provided in Intel Math Library while using 65% less memory.
Recommended diagnostic criteria for paraneoplastic neurological syndromes

Background: Paraneoplastic neurological syndromes (PNS) are defined by the presence of cancer and exclusion of other known causes of the neurological symptoms, but this criterion does not separate “true” PNS from neurological syndromes that are coincidental with a cancer. Objective: To provide more rigorous diagnostic criteria for PNS. Methods: An international panel of neurologists interested in PNS identified those defined as “classical” in previous studies. The panel reviewed the existing diagnostic criteria and recommended new criteria for those in whom no clinical consensus was reached in the past. The panel reviewed all reported onconeural antibodies and established the conditions to identify those that would be labelled as “well characterised”. The antibody information was obtained from published work and from unpublished data from the different laboratories involved in the study. Results: The panel suggest two levels of evidence to define a neurological syndrome as paraneoplastic: “definite” and “possible”. Each level can be reached combining a set of criteria based on the presence or absence of cancer and the definitions of “classical” syndrome and “well characterised” onconeural antibody. Conclusions: The proposed criteria should help clinicians in the classification of their patients and the prospective and retrospective analysis of PNS cases.
Effect of oxygen concentration on nitrification and denitrification in single activated sludge flocs

Simultaneous nitrification and denitrification (SND) was investigated in the single aeration tank of a municipal wastewater treatment plant. Microelectrode measurements and batch experiments were performed to test for the presence of SND. Microelectrodes recorded the presence of O2 concentration gradients in individual activated sludge flocs. When the O2 concentration in the bulk liquid was <45 μM, anoxic zones were detected within flocs with a larger diameter (approximately 3000 μm). The O2 penetration depth in the floc was found to be dependent on the O2 concentration in the bulk liquid. Nitrification was restricted to the oxic zones, whereas denitrification occurred mainly in the anoxic zones. The nitrification rate of the activated sludge increased with increasing O2 concentration in the bulk liquid, up to 40 μM, and remained constant thereafter. SND was observed in the aerated activated sludge when O2 concentration was in the range of 10 to 35 μM. © 2003 Wiley Periodicals, Inc. Biotechnol Bioeng 83: 604–607, 2003.
The impact of playout policy on the performance of P2P live streaming: or how not to kill your P2P advantage

In this paper we examine the impact of the adopted playout policy on the performance of P2P live streaming systems. We argue and demonstrate experimentally that (popular) playout policies which permit the divergence of the playout points of different nodes can deteriorate drastically the performance of P2P live streaming. Consequently, we argue in favor of keeping different playout points "near-in-time", even if this requires sacrificing (dropping) some late frames that could otherwise be rendered (assuming no strict bidirectional interactivity requirements are in place). Such nearly synchronized playout policies create "positive correlation" with respect to the available frames at different playout buffers. Therefore, they increase the number of upstream relay nodes from which a node can pull frames and thus boost the playout quality of both single-parent (tree) and multiple-parent (mesh) systems. On the contrary, diverging playout points reduce the number of upstream parents that can offer a gapless relay of the stream. This is clearly undesirable and should be avoided as it contradicts the fundamental philosophy of P2P systems which is to supplement an original service point with as many additional ones presented by the very own users of the service.
Fluid substitution in porous rocks and the Brown and Korringa theory

Upon revisiting the Brown and Korringa theory we found that there is an internal inconsistency related to the underlying porosity changes associated with the compression of micro-inhomogeneous rocks. The origin of this inconsistency is the use of an incomplete differential in their derivation of the undrained bulk modulus. This inconsistency can result in unphysical predictions. Once this oversight is corrected, the resulting undrained bulk modulus coincides with the undrained bulk modulus obtained within the general poroelasticity framework. The results may have consequences for fluid substitution performed in fluid-saturated, porous rocks with complex mineralogy and internal structure.
The Role of Ultrasound in Diagnosis of the Causes of Low Back Pain: a Review of the Literature

Context: Low back pain (LBP) is among the most prevalent musculoskeletal conditions in the developed countries. It is a common problem causing disability and imposing a huge economic burden to individuals and state organizations. Imaging plays an important role in diagnosis of the etiology of LBP. Evidence Acquisition: The electronic databases included: PubMed (1950 to present), Ovid SP Medline (1950 to present) and ISI (1982 to present) and Google Scholar. In every search engine another search was performed using various permutations of the following keywords: ultrasonography, ultrasound imaging, low back pain, back muscles, paraspinal muscles, multifidus, transverse abdominis, muscle size, spinal canal, sacroiliac joint and spondylolisthesis. Results: Magnetic resonance imaging (MRI) is widely used in evaluation of patients with LBP; however, high costs, limited availability and contraindications for its use have restricted MRI utilization. In a quest for a less expensive and readily available tool to investigate LBP, clinicians and researchers found ultrasonography (US) as an alternative. In this review we discuss the US application in diagnosis of some common causes of non-specific chronic LBP. Discussed topics include evaluation of spinal canal diameter, paraspinal and transabdominal muscles, sacroiliac joint laxity, pregnancy related LBP, sacroiliitis, and spondylolisthesis using US in patients with LBP. Conclusions: While the first researches on employing ultrasound in diagnosis of patients with LBP had been focused on spinal canal diameter, recent studies have been mostly performed to evaluate the role of transabdominal and paraspinal muscles on core stability and thereby LBP occurrence. On the other side, Doppler ultrasonography has recently played an important role in objective measurement of joint laxity as a common etiology for LBP. Doppler imaging also in pregnant patients with LBP has been recommended as a safe and sensitive method. As conclusion, according to recent and most prestigious studies, focusing more on transabdominal muscle thickness can be considered as future approach in investigations.
Development of matrix controlled transdermal delivery systems of pentazocine: In vitro/in vivo performance

Development of matrix controlled transdermal delivery systems of pentazocine: In vitro/in vivo performance The present study aimed to develop hydroxypropyl methylcellulose based transdermal delivery of pentazocine. In formulations containing lower proportions of polymer, the drug released followed the Higuchi kinetics while, with an increase in polymer content, it followed the zero-order release kinetics. Release exponent (n) values imply that the release of pentazocine from matrices was non-Fickian. FT-IR, DSC and XRD studies indicated no interaction between drug and polymer. The in vitro dissolution rate constant, dissolution half-life and pharmacokinetic parameters (Cmax, tmax, AUC(s), t1/2, Kel, and MRT) were evaluated statistically by two-way ANOVA. A significant difference was observed between but not within the tested products. Statistically, a good correlation was found between per cent of drug absorbed from patches vs. Cmax and AUC(s). A good correlation was also observed when per cent drug released was correlated with the blood drug concentration obtained at the same time point. The results of this study indicate that the polymeric matrix films of pentazocine hold potential for transdermal drug delivery. Razvoj matriksnih sustava za transdermalnu isporuku pentazocina: In vitro/in vivo ispitivanje U radu je opisan razvoj transdermalnih sustava na bazi hidroksipropil metilceluloze za isporuku pentazocina. U pripravcima koji sadrže manje udjele polimera, otpuštanje lijeka slijedilo je Higuchijevu kinetiku. Međutim, ako je udio polimera veći oslobađanje je najbolje odgovaralo kinetici nultog reda. Vrijednost eksponenta n implicira da oslobađanje pentazocina iz matriksa nije po Fickovom zakonu. FT-IR, DSC i XRD studije ukazuju da nema interakcije između ljekovite tvari i polimera. In vitro konstanta oslobađanja, poluvrijeme oslobađanja i farmakokinetički parametri (Cmax, tmax, AUC(s), t1/2, Kel, i MRT) procijenjeni su statistički koristeći ANOVA program. Značajna razlika primijećena je između, ali ne i unutar testiranih pripravaka. Pronađena je dobra korelacija između lijeka apsorbiranog iz flastera i Cmax i AUC(s) te oslobođenog lijeka i koncentracije lijeka u krvi. Rezultati ukazuju da su polimerni matriksni filmovi pentazocina potencijalno dobri sustavi za transdermalnu primjenu lijeka.
Relation between arterial blood pressure and cerebral blood flow velocity in simulated sleep apnea

Obstructive Sleep Apnea (OSA) is one of the most common breathing disorder, affecting approximately 27% of U.S. adults. Limited data have suggested that OSA causes cerebral autoregulation impairment, thus being an important risk factor to stroke. The objective of this paper is to investigate and measure the relation between arterial blood pressure (BP) and cerebral blood flow velocity (CBFV) in simulated apnea. Sixteen healthy subjects (9 male, 7 female) of 29±4.89 yrs age and body mass index of 24.07±4.84 kg/m2 participated in the study. Four protocols were used; sitting 30 seconds, 90s, and supine 30s and 90s. Our results showed that systolic BP and peak CBFV were correlated with average r=0.672 +0.265. Also, CBFV exhibited a significantly higher percent rise than BP. Thus, our findings suggest that cerebral autoregulation may be impaired during apnea episodes.