Miracle-dz/UniFAR-FTUs huggingface dataset:
Trust and Credibility in Web-Based Health Information: A Review and Agenda for Future Research

Background Internet sources are becoming increasingly important in seeking health information, such that they may have a significant effect on health care decisions and outcomes. Hence, given the wide range of different sources of Web-based health information (WHI) from different organizations and individuals, it is important to understand how information seekers evaluate and select the sources that they use, and more specifically, how they assess their credibility and trustworthiness. Objective The aim of this study was to review empirical studies on trust and credibility in the use of WHI. The article seeks to present a profile of the research conducted on trust and credibility in WHI seeking, to identify the factors that impact judgments of trustworthiness and credibility, and to explore the role of demographic factors affecting trust formation. On this basis, it aimed to identify the gaps in current knowledge and to propose an agenda for future research. Methods A systematic literature review was conducted. Searches were conducted using a variety of combinations of the terms WHI, trust, credibility, and their variants in four multi-disciplinary and four health-oriented databases. Articles selected were published in English from 2000 onwards; this process generated 3827 unique records. After the application of the exclusion criteria, 73 were analyzed fully. Results Interest in this topic has persisted over the last 15 years, with articles being published in medicine, social science, and computer science and originating mostly from the United States and the United Kingdom. Documents in the final dataset fell into 3 categories: (1) those using trust or credibility as a dependent variable, (2) those using trust or credibility as an independent variable, and (3) studies of the demographic factors that influence the role of trust or credibility in WHI seeking. There is a consensus that website design, clear layout, interactive features, and the authority of the owner have a positive effect on trust or credibility, whereas advertising has a negative effect. With regard to content features, authority of the author, ease of use, and content have a positive effect on trust or credibility formation. Demographic factors influencing trust formation are age, gender, and perceived health status. Conclusions There is considerable scope for further research. This includes increased clarity of the interaction between the variables associated with health information seeking, increased consistency on the measurement of trust and credibility, a greater focus on specific WHI sources, and enhanced understanding of the impact of demographic variables on trust and credibility judgments.
Organizational Change Around an Older Workforce

Purpose of the Study Demographic, economic, political, and technological transformations-including an unprecedented older workforce-are challenging outdated human resource logics and practices. Rising numbers of retirement-eligible Boomers portend a loss of talent, skills, and local knowledge. We investigate organizational responses to this challenge-institutional work disrupting age-graded mindsets and policies. Design and Methods We focus on innovative U.S. organizations in the Minneapolis-St. Paul region in the state of Minnesota, a hub for businesses and nonprofits, conducting in-depth interviews with informants from a purposive sample of 23 for-profit, nonprofit, and government organizations. Results Drawing on an organizational change theoretical approach, we find organizations are leading change by developing universal policies and practices, not ones intentionally geared to older workers. Both their narratives and strategies-opportunities for greater employee flexibility, training, and scaling back time commitments-suggest deliberate disrupting of established age-graded logics, replacing them with new logics valuing older workers and age-neutral approaches. Organizations in the different sectors studied are fashioning uniform policies regardless of age, exhibiting a parallel reluctance to delineate special policies for older workers. Implications Developing new organizational logics and practices valuing, investing in, and retaining older workers is key 21st century business challenges. The flexibility, training, and alternative pathways offered by the innovative organizations we studied point to fruitful possibilities for large-scale replacement of outdated age-biased templates of work, careers, and retirement.
Copy Number Variant in the Region of Adenosine Kinase (ADK) and Its Possible Contribution to Schizophrenia Susceptibility

Abstract Background Adenosine kinase (ADK) is supposed to be a schizophrenia susceptibility gene based on the findings that ADK is an enzyme that catalyzes transfer of the gamma-phosphate from ATP to adenosine, which interacts with dopamine and glutamate neurotransmitters. However, no reports of schizophrenia cases with loss of function variants in the ADK region have been published. In our previous study investigating copy number variants in schizophrenia, we detected a copy number variant in the ADK region in 1 of 1699 schizophrenia patients. Methods We validated the ADK deletion by determining the breakpoint. Then, we compared the relative expression of ADK in 32 schizophrenia patients, including a schizophrenia patient with deletion of ADK, with 29 healthy controls using lymphoblastoid cell lines. Furthermore, we evaluated the clinical phenotypes of the schizophrenia with ADK deletion. Result We validated the copy number variants with Sanger sequencing and predicted that this copy number variant results in loss of function of ADK. Furthermore, expression analysis of mRNA from peripheral blood in this schizophrenia patient with the ADK deletion showed an extremely low level of ADK. Here we describe a case report of a patient with ADK deletion with phenotypes (schizophrenia, parkinsonism, epilepsy) that are predicted when ADK function is disrupted. Conclusion Considering that the patient had a low ADK mRNA level and showed a phenotype that may be related to ADK deficiency, the copy number variants in the region of ADK may be strongly related to the phenotypes described here, such as schizophrenia, Parkinsonism, and epilepsy.
The Stroke Filter Based Caption Extraction System Miss . Dharmini

Captions in videos provide rich semantic information the contents of the video can be clearly understand with help of the captions. Without even seeing the video the person can understand about the video by knowing the captions in the video. By considering these reasons captions extraction in videos become an important prerequisite. In this paper we use a stroke filter, the stroke filter identifies the strokes in the video and usually caption regions have strokes such that the strokes identified belongs to captions by which the captions are detected. Then the locations of the captions are localized. In the next Step the caption pixels are separated from the background pixels. At last a post processing step is performed to check whether the correct caption pixels are extracted. In this paper a step by step sequential procedure to extract captions from videos is
Probing Nuclear PDF and Gluon Saturation At The LHC with Forward Direct Photons

In relativistic nuclear collisions some of the important aspects to be addressed are the effects of the nuclear PDF and the gluon saturation. In the LHC the best way to address these questions is by means of pA collisions and in particular through the measurement of direct photon production in the forward direction. In order to achieve this measurement a new forward calorimeter (FoCal) is proposed as an upgrade to the ALICE experiment. The proposed detector will cover the range 3.5 4 GeV. We will discuss performance studies and demonstrate that extremely high-granularity calorimetry is required for such measurement. We will also present a few results from R&D for this project.
False Recognition in Alzheimer Disease: Evidence from Categorized Pictures

ObjectivesTo better understand memory distortions and false recognition in patients with Alzheimer disease (AD), using a paradigm of categorized color photographs. BackgroundPrevious research has found that patients with AD and older adults showed similar levels of uncorrected false recognition of semantic associates and of perceptually related novel objects. In contrast to these results, using a paradigm in which semantically related words were accompanied by black and white line drawings, it was found that patients with AD showed a trend toward higher levels of uncorrected false recognition compared with older adults. MethodsTo explore this trend, 24 patients with AD and 24 older adults matched for age, education, and gender were examined using a false recognition paradigm consisting of categorized color photographs (e.g., flowers, motorcycles, cats). ResultsCompared with older adults, patients with AD showed higher levels of uncorrected false recognition, but lower levels of corrected false recognition and lower levels of item-specific recollection. ConclusionsThe authors suggest that these results may be attributable to the poor ability of patients with AD to acquire both gist and item-specific information as well as these patients' inherent frontal lobe dysfunction leading to difficulty inhibiting responses on the basis of familiarity alone.
Three Factor Authentication Schemes for the Automation of Inter-Networked banking and Teller Machine operations using Universal Subscriber Identification Modules

Automated teller machines (ATMs) are well known devices typically used by individuals to carry out a variety of personal and business financial transactions and/or banking functions. ATMs have become very popular with the general public for their availability and general user friendliness. ATMs are now found in many locations having a regular or high volume of consumer traffic. Various services and resources need protection from unauthorized use. Remote authentication is the most commonly used method to determine the identity of a remote client. This paper investigates a systematic approach for authenticating clients by three factors, namely password, smart card, and biometrics. Biometrics is the identification of humans by their characteristics or traits. A physiological biometric would identify by one's voice, Face, hand print or behaviour. Since biometric identifiers are unique to individuals, they are more reliable in verifying identity than token and knowledge-based methods. Keywords— User authentication, Smart card, Face Recognition and security
Remote Monitoring of Patients With Heart Failure: An Overview of Systematic Reviews

Background Many systematic reviews exist on the use of remote patient monitoring (RPM) interventions to improve clinical outcomes and psychological well-being of patients with heart failure. However, research is broadly distributed from simple telephone-based to complex technology-based interventions. The scope and focus of such evidence also vary widely, creating challenges for clinicians who seek information on the effect of RPM interventions. Objective The aim of this study was to investigate the effects of RPM interventions on the health outcomes of patients with heart failure by synthesizing review-level evidence. Methods We searched PubMed, EMBASE, CINAHL (Cumulative Index to Nursing and Allied Health Literature), and the Cochrane Library from 2005 to 2015. We screened reviews based on relevance to RPM interventions using criteria developed for this overview. Independent authors screened, selected, and extracted information from systematic reviews. AMSTAR (Assessment of Multiple Systematic Reviews) was used to assess the methodological quality of individual reviews. We used standardized language to summarize results across reviews and to provide final statements about intervention effectiveness. Results A total of 19 systematic reviews met our inclusion criteria. Reviews consisted of RPM with diverse interventions such as telemonitoring, home telehealth, mobile phone–based monitoring, and videoconferencing. All-cause mortality and heart failure mortality were the most frequently reported outcomes, but others such as quality of life, rehospitalization, emergency department visits, and length of stay were also reported. Self-care and knowledge were less commonly identified. Conclusions Telemonitoring and home telehealth appear generally effective in reducing heart failure rehospitalization and mortality. Other interventions, including the use of mobile phone–based monitoring and videoconferencing, require further investigation.
Proteomics of Aspergillus fumigatus Conidia-containing Phagolysosomes Identifies Processes Governing Immune Evasion*

Invasive infections by the human pathogenic fungus Aspergillus fumigatus start with the outgrowth of asexual, airborne spores (conidia) into the lung tissue of immunocompromised patients. The resident alveolar macrophages phagocytose conidia, which end up in phagolysosomes. However, A. fumigatus conidia resist phagocytic degradation to a certain degree. This is mainly attributable to the pigment 1,8-dihydroxynaphthalene (DHN) melanin located in the cell wall of conidia, which manipulates the phagolysosomal maturation and prevents their intracellular killing. To get insight in the underlying molecular mechanisms, we comparatively analyzed proteins of mouse macrophage phagolysosomes containing melanized wild-type (wt) or nonmelanized pksP mutant conidia. For this purpose, a protocol to isolate conidia-containing phagolysosomes was established and a reference protein map of phagolysosomes was generated. We identified 637 host and 22 A. fumigatus proteins that were differentially abundant in the phagolysosome. 472 of the host proteins were overrepresented in the pksP mutant and 165 in the wt conidia-containing phagolysosome. Eight of the fungal proteins were produced only in pksP mutant and 14 proteins in wt conidia-containing phagolysosomes. Bioinformatical analysis compiled a regulatory module, which indicates host processes affected by the fungus. These processes include vATPase-driven phagolysosomal acidification, Rab5 and Vamp8-dependent endocytic trafficking, signaling pathways, as well as recruitment of the Lamp1 phagolysosomal maturation marker and the lysosomal cysteine protease cathepsin Z. Western blotting and immunofluorescence analyses confirmed the proteome data and moreover showed differential abundance of the major metabolic regulator mTOR. Taken together, with the help of a protocol optimized to isolate A. fumigatus conidia-containing phagolysosomes and a potent bioinformatics algorithm, we were able to confirm A. fumigatus conidia-dependent modification of phagolysosomal processes that have been described before and beyond that, identify pathways that have not been implicated in A. fumigatus evasion strategy, yet. Mass spectrometry proteomics data are available via ProteomeXchange with identifiers PXD005724 and PXD006134.
Selective localization of titanium dioxide nanoparticles at the interface and its effect on the impact toughness of poly(L-lactide)/poly(ether)urethane blends

Inorganic nanofillers are often added into polymer/elastomer blends as a third component to modify their per- formance. This work aims to clarify the role of interface-localized spherical nanoparticles in determining the impact tough- ness of polymer blends. The selective distribution of titanium dioxide (TiO2) nanoparticles in poly(L-lactide)/poly(ether) urethane (PLLA/PU) blends was investigated by using scanning electron microscope. It is interesting to find that, regard- less of the method of TiO2 introduction, nano-TiO2 particles are always selectively localized at the phase interface between PLLA and PU, leading to a significant improvement in notched Izod impact toughness. The moderately weakened interfa- cial adhesion induced by the interfacially-localized nano-TiO2 particles is believed to be the main reason for the largely enhanced impact toughness.
First outbreak of Zika virus in the continental United States: a modelling analysis

Since 2015, Zika virus (ZIKV) has spread throughout Latin and Central America. This emerging infectious disease has been causing considerable public health concern because of severe neurological complications, especially in newborns after congenital infections. In July 2016, the first outbreak in the continental United States was identified in the Wynwood neighbourhood of Miami-Dade County, Florida. In this work, we investigated transmission dynamics using a mathematical model calibrated to observed data on mosquito abundance and symptomatic human infections. We found that, although ZIKV transmission was detected in July 2016, the first importation may have occurred between March and mid-April. The estimated highest value for R0 was 2.73 (95% confidence interval (CI): 1.65–4.17); the attack rate was 14% (95% CI: 5.6–27.4%), with 15 (95% CI: 6–29) pregnant women involved and a 12% probability of infected blood donations. Vector control avoided 60% of potential infections. According to our results, it is likely that further ZIKV outbreaks identified in other areas of Miami-Dade County were seeded by commuters to Wynwood rather than by additional importation from international travellers. Our study can help prepare future outbreak-related interventions in European areas where competent mosquitoes for ZIKV transmission are already established.
Lipid Trafficking between the Endoplasmic Reticulum and the Plastid in Arabidopsis Requires the Extraplastidic TGD4 Protein[W]

The development of chloroplasts in Arabidopsis thaliana requires extensive lipid trafficking between the endoplasmic reticulum (ER) and the plastid. The biosynthetic enzymes for the final steps of chloroplast lipid assembly are associated with the plastid envelope membranes. For example, during biosynthesis of the galactoglycerolipids predominant in photosynthetic membranes, galactosyltransferases associated with these membranes transfer galactosyl residues from UDP-Gal to diacylglycerol. In Arabidopsis, diacylglycerol can be derived from the ER or the plastid. Here, we describe a mutant of Arabidopsis, trigalactosyldiacylglycerol4 (tgd4), in which ER-derived diacylglycerol is not available for galactoglycerolipid biosynthesis. This mutant accumulates diagnostic oligogalactoglycerolipids, hence its name, and triacylglycerol in its tissues. The TGD4 gene encodes a protein that appears to be associated with the ER membranes. Mutant ER microsomes show a decreased transfer of lipids to isolated plastids consistent with in vivo labeling data, indicating a disruption of ER-to-plastid lipid transfer. The complex lipid phenotype of the mutant is similar to that of the tgd1,2,3 mutants disrupted in components of a lipid transporter of the inner plastid envelope membrane. However, unlike the TGD1,2,3 complex, which is proposed to transfer phosphatidic acid through the inner envelope membrane, TGD4 appears to be part of the machinery mediating lipid transfer between the ER and the outer plastid envelope membrane. The extent of direct ER-to-plastid envelope contact sites is not altered in the tgd4 mutant. However, this does not preclude a possible function of TGD4 in those contact sites as a conduit for lipid transfer between the ER and the plastid.
Sparsity-Enhancing Basis for Compressive Sensing Based Channel Feedback in Massive MIMO Systems

Massive multiple-input multiple-output (MIMO) systems have attracted extensive attention recently due to their potentials to provide high system capacity. To obtain the benefits of massive MIMO systems, channel state information (CSI) at the transmitter is essential. The high overhead of traditional channel estimation and feedback scheme for downlink massive MIMO systems makes frequency division duplexing (FDD) impractical. Compressive sensing (CS) is a potential way to alleviate the problem. In this paper, we mainly focus on the CS- based feedback design. To guarantee the performance of the CS-based algorithms, a proper basis to reveal the sparsity of the channel is important. Here, we use the statistical information of the angle-of-departure (AoD) of physical channel paths for the basis design. A $l_0$-norm based basis optimization problem is first formulated. Then, the problem is relaxed by a weighted $l_1$-norm and is solved by an iterative algorithm. The mean-square-error (MSE) performance of the CS-based feedback scheme based on our proposed basis is better than the traditional discrete Fourier transform (DFT) basis.
Nonwovens Containing Immobilized Superabsorbent Polymer Particles

In the early 1980's Johnson & Johnson developed a revolutionary process for the production of webs containing superabsorbent polymers (SAP) produced by in-situ polymerization of partially neutralized acrylic monomers directly on a synthetic nonwoven substrate [1, 2, 3, 4]. A fresh look at this forgotten technology will be presented from both a manufacturing and application perspective. In particular, In-situ, SAP-containing nonwovens offer many unique properties for application in the personal hygiene industry, such as, improved fluid acquisition, permeability, compressibility and pH control. These materials also provide a more homogenous SAP distribution, eliminate the need for SAP powder handling and have superior wet integrity as compared to conventional fluff pulp/SAP air laid structures. This technology also offers some unique opportunities for designing and manufacturing profiled absorbent articles with specific zones tailored to perform specific functions.
VEGF-mediated angiogenesis and vascularization of a fumarate-crosslinked polycaprolactone (PCLF) scaffold

ABSTRACT Purpose: Revascularization of natural and synthetic scaffolds is a critical part of the scaffold’s incorporation and tissue ingrowth. Our goals were to create a biocompatible polymer scaffold with 3D-printing technology, capable of sustaining vascularization and tissue ingrowth. Methods: We synthesized biodegradable polycaprolactone fumarate (PCLF) scaffolds to allow tissue ingrowth via large interconnected pores. The scaffolds were prepared with Poly(lactic-co-glycolic acid)(PLGA) microspheres seeded with or without different growth factors including VEGF,FGF-2, and/or BMP-2. Scaffolds were implanted into the subcutaneous tissues of rats before undergoing histologic and microCT angiographic analysis. Results: At harvest after 12 weeks, scaffolds had tissue infiltrating into their pores without signs of scar tissue formation, fibrous capsule formation, or immune responses against PCLF. Histology for M1/M2 macrophage phenotypes confirmed that there were no overt signs of immune responses. Both microCT angiography and histologic analysis demonstrated marked tissue and vessel ingrowth throughout the pores traversing the body of the scaffolds. Scaffolds seeded with microspheres containing VEGF or VEGF with either BMP-2 or FGF-2 had significantly higher vascular ingrowth and vessel penetration than controls. All VEGF-augmented scaffolds were positive for Factor-VIII and exhibited collagen tissue infiltration throughout the pores. Furthermore, scaffolds with VEGF and BMP-2 had high levels of mineral deposition throughout the scaffold that are attributable to BMP-2. Conclusions: PCLF polymer scaffold can be utilized as a framework for vascular ingrowth and regeneration of multiple types of tissues. This novel scaffold material has promise in tissue regeneration across all types of tissues from soft tissue to bone.