Miracle-dz/UniFAR-FTUs huggingface dataset:
Sensitivity of Model-Based Predictions of Post-TKA Kinematic Behavior to Residual Errors in Ultrasound-Based Knee Collateral Ligament Strain Assessment

Ultrasound-based ligament strain estimation shows promise in non-invasively assessing knee joint collateral ligament behavior and improving ligament balancing procedures. However, the impact of ultrasound-based strain estimation residual errors on in-silico arthroplasty predictions remains unexplored. We investigated the sensitivity of post-arthroplasty kinematic predictions to ultrasound-based strain estimation errors compared to clinical inaccuracies in implant positioning.Two cadaveric legs were submitted to active squatting, and specimen-specific rigid computer models were formulated. Mechanical properties of the ligament model were optimized to reproduce experimentally obtained tibiofemoral kinematics and loads with minimal error. Resulting remaining errors were comparable to the current state-of-the-art. Ultrasound-derived strain residual errors were then introduced by perturbing lateral collateral ligament (LCL) and medial collateral ligament (MCL) stiffness. Afterwards, the implant position was perturbed to match with the current clinical inaccuracies reported in the literature. Finally, the impact on simulated post-arthroplasty tibiofemoral kinematics was compared for both perturbation scenarios. Ultrasound-based errors minimally affected kinematic outcomes (mean differences < 0.73° in rotations, 0.1 mm in translations). Greatest differences occurred in external tibial rotations (−0.61° to 0.73° for MCL, −0.28° to 0.27° for LCL). Comparatively, changes in implant position had larger effects, with mean differences up to 1.95° in external tibial rotation and 0.7 mm in mediolateral translation. In conclusion, our study demonstrated that the ultrasound-based assessment of collateral ligament strains has the potential to enhance current computer-based pre-operative knee arthroplasty planning.
Data Quality Analysis and Improvement: A Case Study of a Bus Transportation System

Due to the rapid development of the mobile Internet and the Internet of Things, the volume of generated data keeps growing. The topic of data quality has gained increasing attention recently. Numerous studies have explored various data quality (DQ) problems across several fields, with corresponding effective data-cleaning strategies being researched. This paper begins with a comprehensive and systematic review of studies related to DQ. On the one hand, we classify these DQ-related studies into six types: redundant data, missing data, noisy data, erroneous data, conflicting data, and sparse data. On the other hand, we discuss the corresponding data-cleaning strategies for each DQ type. Secondly, we examine DQ issues and potential solutions for a public bus transportation system, utilizing a real-world traffic big data platform. Finally, we provide two representative examples, noise filtering and filling missing values, to demonstrate the DQ improvement practice. The experimental results show that: (1) The GPS noise filtering solution we proposed surpasses the baseline and achieves an accuracy of 97%; (2) The multi-source data fusion method can achieve a 100% missing repair rate (MRR) for bus arrival and departure. The average relative error (ARE) of bus arrival and departure times at stations is less than 1%, and the correlation coefficient (R) is also close to 1. Our research can offer guidance and lessons for enhancing data governance and quality improvement in the bus transportation system.
Efficacy and safety of zolbetuximab for first-line treatment of advanced Claudin 18. 2-positive gastric or gastro-esophageal junction adenocarcinoma: a systematic review and meta-analysis of randomized controlled trials

Objective Zolbetuximab is a “first-in-class” chimeric lgG1 monoclonal antibody targeting Claudin18.2 (CLDN 18.2). In recent years, several important trials have been published showing that zolbetuximab is associated with improved prognosis in patients with advanced gastric or gastro-esophageal junction (G/GEJ) adenocarcinoma. This promises great change to the current treatment landscape. Therefore, we conducted a systematic review and meta-analysis to evaluate the efficacy and safety of zolbetuximab for first-line treatment of advanced CLDN 18. 2-positive G/GEJ adenocarcinoma. Methods The following databases were searched for relevant studies: PubMed, EMBASE, and Cochrane library (updated 10 June 2023). All randomized trials comparing zolbetuximab plus chemotherapy versus first-line chemotherapy alone for first-line treatment of advanced CLDN 18. 2-positive G/GEJ adenocarcinoma were eligible for inclusion. Data were analyzed using Review Manager 5.4. 1 (Cochrane collaboration software). Primary outcomes and measures included overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and adverse events (AEs). Results This systematic review and meta-analysis included three randomized controlled studies involving 1,402 patients (699 receiving zolbetuximab plus chemotherapy and 703 receiving chemotherapy alone). Compared with chemotherapy alone, zolbetuximab plus chemotherapy significantly improved OS (HR = 0.73; 95% CI: 0.68–0.84) and PFS (HR = 0.64; 95% CI: 0.50–0.82), but did not result in a higher ORR (RR = 0.92; 95% CI: 0.82–1.03). Further analysis of CLDN 18.2 expression showed a more significant benefit for OS (HR = 0.69; 95% CI: 0.55–0.87; p = 0.002) and PFS (HR = 0.61; 95% CI: 0.44–0.84; p = 0.003) from zolbetuximab in patients with high expression, while there was significant benefit in patients with lower expression. In terms of AEs, zolbetuximab plus chemotherapy was associated with higher risk of grade 3 and higher AEs, but increased risk of nausea and vomiting were more common. Conclusion This systematic review and meta-analysis revealed that the effect of zolbetuximab plus chemotherapy was superior to that of chemotherapy alone for first-line treatment of advanced CLDN 18.2-positive G/GEJ adenocarcinoma. Thus, zolbetuximab plus chemotherapy represents a new first-line treatment for these patients. Zolbetuximab plus chemotherapy was associated with higher risk of grade 3 and higher AEs, but was generally manageable. Systematic Review Registration https://www.crd. york.ac. uk/prospero, identifier (CRD42023437126).
The atmospheric correction for satellite infrared radiometer data in polar regions

Mie scattering models suggest that the thermal infrared emissivity of snow is relatively insensitive to variations in its properties and is dependent, primarily, on viewing angle. This gives rise to the possibility of accurately measuring snow surface temperatures, over the polar ice sheets, using satellite infrared radiometers operating in the window region at 10–13 microns. These instruments were designed, primarily, to measure sea surface temperature and a substantial body of work has been undertaken on correcting for the effects of variable absorption by the atmosphere over oceans. The atmospheric conditions over the Antarctic and Greenland ice sheets are significantly different, however, and require special treatment. A three year dataset of radiosonde measurements, collected from six Antarctic stations, is used to investigate the behaviour of the “split-window” algorithm. The same dataset has been used to test the performance of a dual-view algorithm that can be used with the Along Track Scanning Radiometer onboard ERS-1. It is shown that, given accurate emissivity estimates, the atmospheric correction has an rms error of 0.015 K using the dual-view method. Combined with the excellent calibration and stability of the Along Track Scanning Radiometer and pixel averaging to reduce the detector noise it is possible to derive snow surface “skin” temperatures to an accuracy of about 0.1 K.
Impact of High-resolution Regional Climate Conditions on the Moisture Performance of Wood-frame Building Envelopes

Climate data is one of the most important inputs for hygrothermal simulations and significantly influences the simulation results that are used for moisture performance assessment of building envelopes. Conventionally, climate data from representative weather stations are used for hygrothermal simulations to assess the moisture performance of the buildings. Recently, the Construction Research Centre of the National Research Council Canada generated historical and future climate data for 564 locations across Canada. In this paper, the climate data of four urban locations within Vancouver (a humid and warm coastal city in Canada) were selected for hygrothermal simulations. These include an open area at the airport, a city center, an area surrounded by plants, and an area surrounded by a water body. The 31-year-long simulations were performed for a typical wood-frame wall assembly complying with moisture protection designs as provided in the National Building Code Canada (NBCC 2020) but rain penetration was assumed considering the deficiency of exterior cladding. The differences in its hygrothermal response across the four locations were analyzed. It was found that some climate parameters are significantly different among the selected locations, although the values for moisture indices given in the NBCC 2020 for these locations are all similar. The results show that high values of WDR are the dominant factor that drives the moisture performance but there is no indication that the design of the assembly could be different among the tested locations.
DATING BORNEO'S DELTAIC DELUGE: MIDDLE MIOCENE PROGRADATION OF THE MAHAKAM DELTA

ABSTRACT Borneo's geologic and paleontological history remains poorly understood because of the lack of outcrops and difficulties with dating. Urban development around the city of Samarinda has produced over four kilometers of well-exposed stratigraphy depicting the progradation of the ancient Mahakam river delta across the Samarinda area, which includes slope, shelf, and deltaic deposits (clastic and carbonate). Previous studies have preliminarily dated the succession as middle Miocene, but reworking and the scarcity of diagnostic fossils make dating difficult. In this paper, an integrated stratigraphic age model has been constructed for the middle Miocene of the Samarinda region with a combination of magnetostratigraphy, sequence stratigraphy, and biostratigraphy (nannofossil, planktonic foraminifera, and larger benthic foraminifera). This age model provides improved temporal constraints for part of the Mahakam Delta succession. It also helps to place the pattern of biodiversity changes seen in Indonesian reef communities into a better time perspective, and permits more accurate sedimentation rates to be determined. It may also serve as a reference point to compare other Neogene sections in Southeast Asia. The two reef complexes at Samarinda, the Batu Putih and the Stadion section, are magnetostratigraphically dated at ∼ 15 Ma and 11.6 Ma, respectively. The new chronology for the Samarinda succession shows that the Mahakam Delta went through a major phase of buildout and progradation during the middle and earliest late Miocene, during which time progradation across the former shelf break took place in the Samarinda area.
Simulation of CO 2 and latent heat fluxes in the North China Plain

We constructed a coupled model for simulating plant photosynthesis and evapotranspiration (CPCEM). In the model, non-rectangular hyperbola is used to simulate leaf photosynthesis rate that is scaled up to estimate canopy gross photosynthesis rate by an integral method. Whole canopy in the model is separated into multi-layers, each of which is divided into sunlit leaves and shade leaves. Canopy net photosynthesis rate is expressed as a function of canopy conductance which is coupled with evapotranspiration. Included the coupled function, evapotranspiration is estimated with a two-layer submodel. The main features of CPCEM are: (1) easy suitability, (2) good physiological base, and (3) simple calculation procedure. Simulated results of CPCEM were compared with those by an eddy covariance system that was installed in a winter wheat farmland of the North China Plain. CPCEM gave a quite well diurnal and seasonal dynamics of net ecosystem exchange, compared with the measurements. The root mean square error between simulation and measurements was only about 2.94 μmol m-2 s-1. Diurnal and seasonal patterns of latent heat flux with the CPCEM were similar to those of measurements. Whereas, simulated latent heat flux was evidently higher than the measured.
Effect of clay content and mineralogy on frictional sliding behavior of simulated gouges: Binary and ternary mixtures of quartz, illite, and montmorillonite

[1] We investigated the frictional sliding behavior of simulated quartz-clay gouges under stress conditions relevant to seismogenic depths. Conventional triaxial compression tests were conducted at 40 MPa effective normal stress on saturated saw cut samples containing binary and ternary mixtures of quartz, montmorillonite, and illite. In all cases, frictional strengths of mixtures fall between the end-members of pure quartz (strongest) and clay (weakest). The overall trend was a decrease in strength with increasing clay content. In the illite/quartz mixture the trend was nearly linear, while in the montmorillonite mixtures a sigmoidal trend with three strength regimes was noted. Microstructural observations were performed on the deformed samples to characterize the geometric attributes of shear localization within the gouge layers. Two micromechanical models were used to analyze the critical clay fractions for the two-regime transitions on the basis of clay porosity and packing of the quartz grains. The transition from regime 1 (high strength) to 2 (intermediate strength) is associated with the shift from a stress-supporting framework of quartz grains to a clay matrix embedded with disperse quartz grains, manifested by the development of P-foliation and reduction in Riedel shear angle. The transition from regime 2 (intermediate strength) to 3 (low strength) is attributed to the development of shear localization in the clay matrix, occurring only when the neighboring layers of quartz grains are separated by a critical clay thickness. Our mixture data relating strength degradation to clay content agree well with strengths of natural shear zone materials obtained from scientific deep drilling projects.
Correlation of NPDC1 Expression and Perineural Invasion Status with Clinicopathological Features in Patients with Colon Cancer

Background Colon cancer is a prevalent gastrointestinal malignancy that often exhibits distant metastasis, hindering the effectiveness of surgical interventions. In addition to well-known hematogenous and lymphatic metastasis, perineural invasion (PNI) has emerged as a significant mode of distant metastasis in colon tumors. PNI is closely associated with oncologic pain in advanced cancer patients, but the underlying mechanisms and associated biomarkers, which might be the novel therapeutic targets, remain poorly understood. Methods In this study, we employed large databases and bioinformatics methods to identify genes strongly linked to PNI in colon cancer and investigated their involvement in tumor nerve invasion, progression mechanisms, and chemotherapy resistance. Immunohistochemical techniques were utilized to validate the expression of target genes in 384 colon cancer tissues, and their expression was correlated with clinicopathological characteristics and patient survival data in our hospital. Furthermore, we conducted a comprehensive literature review to explore the potential functions of the target genes and their associated genes. Results Our screening revealed a significant correlation between neural proliferation differentiation and control-1 (NPDC1) expression and patient prognosis, suggesting a potential association with neural infiltration in colon cancer. Additionally, NPDC1 may promote tumorigenesis, progression, and chemoresistance through various related pathways. Conclusion Our study provides novel insights into the utility of NPDC1 as a predictive marker for PNI status, disease-free survival, and overall survival in patients with colon cancer, highlighting the prevalence of NPDC1 overexpression in patients with PNI in colon cancer.
Combination of Seismic and Well Log Data with the Use of Attributes and Acoustic Full Waveforms

Problem of combining well logs with seismic data is still a topic of discussions. In this paper full wave sonic logs and seismic attributes are proposed as an innovative way of combining these two measurements. Data from the sandy shaly Miocene formations and the carbonates from Carboniferous formation in the Carpathian Foredeep were analyzed in this paper. Attributes for acoustic waves (P, S and Stoneley) - Amplitude Envelope and Instantaneous Frequency - were calculated. On the other hand, the best set of seismic attributes for prediction the log well data was chosen using multi-linear regression. Next, the log derived attributes were upscaled to the seismic wavelength. Finally, these two types of attributes were compared and some relations were found.
Emergency Automobile Data Transmission with Ant Colony Optimization (ACO)

—Vehicular Adhoc Networks (VANET) have grown in popularity recently. Several analytical challenges must address to build VANETs that improve driver assistance, safety, and traffic management. Another big problem is the development of expandable route findings that can assess fast topography variations and numerous network detachments brought on through excellent vehicle quality. This paper will first discuss extensive technological investigations comprising and defects of the current progressive routing algorithms. Then, author suggests an entirely original routing theme called Emergency Data Transmission using ACO (EDTA). Design this protocol to use any freeway the ambulance driver has access to or any less-traveled paths with the least amount of communication overhead and delay and the highest amount of communication throughput. The patients received treatment more promptly since the driver was alerted earlier. Author developed a novel fitness function for the Ant Colony Optimization (ACO) that concentrates on two crucial vehicle parameters: current travel speed and data/network congestion. The ACO is used to optimize to identify a more stable and reliable channel that enables rapid communication between vehicles. The performance of this protocol will compare to that of a state-of-the-art protocol in conclusion with “average throughput”, “packet delivery ratio”, “communication overhead”
The Impact of Preoperative Patient Education on Postoperative Pain, Opioid Use, and Psychological Outcomes: A Narrative Review

ABSTRACT Background Recent studies have shown that preoperative education can positively impact postoperative recovery, improving postoperative pain management and patient satisfaction. Gaps in preoperative education regarding postoperative pain and opioid use may lead to increased patient anxiety and persistent postoperative opioid use. Objectives The objective of this narrative review was to identify, examine, and summarize the available evidence on the use and effectiveness of preoperative educational interventions with respect to postoperative outcomes. Method The current narrative review focused on studies that assessed the impact of preoperative educational interventions on postoperative pain, opioid use, and psychological outcomes. The search strategy used concept blocks including “preoperative” AND “patient education” AND “elective surgery,” limited to the English language, humans, and adults, using the MEDLINE ALL database. Studies reporting on preoperative educational interventions that included postoperative outcomes were included. Studies reporting on enhanced recovery after surgery protocols were excluded. Results From a total of 761 retrieved articles, 721 were screened in full and 34 met criteria for inclusion. Of 12 studies that assessed the impact of preoperative educational interventions on postoperative pain, 5 reported a benefit for pain reduction. Eight studies examined postoperative opioid use, and all found a significant reduction in opioid consumption after preoperative education. Twenty-four studies reported on postoperative psychological outcomes, and 20 of these showed benefits of preoperative education, especially on postoperative anxiety. Conclusion Preoperative patient education interventions demonstrate promise for improving postoperative outcomes. Preoperative education programs should become a prerequisite and an available resource for all patients undergoing elective surgery.
Virtual Reality Interface Evaluation for Earthwork Teleoperation

Automation and robotics are destined to play a critical role in the Industry 4.0 revolution, as illustrated by the emergence of autonomous machinery in earthwork operations. Despite rapid progress, autonomous agents will always require human supervision to instruct their mission and to guaranty safety when unexpected problems arise. Traditional human supervision requires an operator to physically enter each machine at risk and manually take control. This approach is time-consuming and requires highly qualified personnel capable of operating various machines. This process can be hastened and simplified by means of teleoperated supervision, which itself requires the appropriate interface. In this paper we evaluate a virtual reality (VR)-based interface using hybrid interactions and an immersive digital-twin compared to a real-life control. We compare these interfaces through control tasks performed by expert and non-expert operators, analyzing time and precision, as well as user feedback. The preliminary results show that the VR interface brings equivalent and satisfactory performances for experts and improves the efficiency of apprentices. Therefore, not only does everyone performs well in the virtual environment, but also the training time can be shortened significantly as non-experts can perform similarly under the same conditions.
Light penetration into Clarens sandstone and implications for deterioration of San rock art

In respect to the weathering of cave art exposed to the sun, cognizance has yet to be taken of the modified thermal conditions and the potential for endolithic biotic activity where the art is located on a light‐transmissive lithology. Where light penetrates rock, the light‐to‐heat transfer is not solely at the surface, and this leads to a thermal gradient that is different from where the paintings are located (and all transfer is at the surface). Light values of up to 200 W/m2 were recorded at 0.5 mm depth and up to 100 W/m2 at 1mm depth in the dry sandstone; rock moisture data showed that at this site the rock remained dry irrespective of atmospheric conditions. The light penetration means that there can be rapid and large subsurface thermal fluctuations contemporaneous with those at the rock surface, and that the thermal gradient is not as steep (approximately 1°C/mm in the surficial part of the rock) as where light‐to‐heat transfer is solely at the surface. Further, the presence of subsurface photosynthetically active radiation can (potentially) facilitate colonization by endolithic organisms. Here, as part of a study of the weathering of San rock art on sandstone in southern Africa, a first attempt is made to monitor the extent of light penetration and the resulting thermal conditions in the outer few millimeters of the sandstone. © 2009 Wiley Periodicals, Inc.