Miracle-dz/UniFAR-FTUs huggingface dataset:
Control Of Nuclear Research Reactors Based On A Generalized Hopfield Neural Network

ABSTR4CT-The purpose of tliis paper is to prcsellt a solution to the n~ininlization prohlenl of the transient time to accomplish the switching hetween different levels of power in a nuclear research reactor satislying the inverse period cons~rairtt and avoiding to use any physical model of the plant. 'l'be strategy liere proposed consists of two stazes. first. the optinul trajectory which satisfies the constraint is calculated 00-line: second. a control law based on a generalized Hopfield neuml network is employed to assure that the reactor power l'ollows this optimal tra,iectory. The boundedness Ibr both the weights and the identification error is guaranteed by a new online learning law. Likewise, proposed control law guarantees an nppr bound for the tracking error. The elfbclive~iess of this procedure is illustrated by numeric sinlularion.
Cell Recognition of the Dominant I-A k – restricted Hen Egg Lysozyme Epitope : Critical Role for Asparagine Deamidation

Type-B T cells raised against the immunodominant peptide in hen egg lysozyme (HEL 48–62 ) do not respond to whole lysozyme, and this has been thought to indicate that peptide can bind to l-A k in different conformations. Here we demonstrate that such T cells recognize a deamidated form of the HEL peptide and not the native peptide. The sequence of the HEL epitope facilitates rapid and spontaneous deamidation when present as a free peptide or within a flexible domain. However, this deamidated epitope is not created within intact lysozyme, most likely because it resides in a highly structured part of the protein. These findings argue against the existence of multiple conformations of the same peptide–MHC complex and have important implications for the design of peptide-based vaccines. Furthermore, as the type-B T cells are known to selectively evade induction of tolerance when HEL is expressed as a transgene, these results suggest that recognition of posttranslationally modified self-antigen may play a role in autoimmunity.
A New Greedy Routing Algorithm for Vehicular Ad Hoc Networks

Vehicular ad hoc networks (VANET) are a new generation of wireless mobile networks playing an important role in communication and safety of vehicles. In VANETs, exchange of traffic and road accidents data improves road safety. Packet routing is a critical issue in VANETs. Due to constant changes of network topology and nodes high moving speed in VANETs, mobile ad hoc network (MANET) routing is not effective. The purpose of this study is to investigate routing algorithms based on greedy approach and propose a weight-based greedy algorithm. The results revealed that the proposed algorithm required lower transmission time and fewer steps compared with existing algorithms.
Risk factors for ER visits due to asthma exacerbations in patients enrolled in a program for the control of asthma and allergie rhinitis in Feira de Santana, Brazil..

OBJECTIVE To determine the risk factors for ER visits due to asthma exacerbations in patients monitored at a referral center. METHODS Prospective cohort study of 253 outpatients (children and adults) with asthma who were monitored for 12 months at the Referral Center of the Program for the Control of Asthma and Allergic Rhinitis in the city of Feira de Santana, Brazil. RESULTS Exacerbations were common, and 36.5% of the patients sought ER treatment within the twelve-month period. The risk factors for asthma exacerbations were being over 20 years of age (OR = 1.34: (95% CI: 1.06-1.70), residing in an urban area (OR = 1.19; 95% CI: 1.06-1.33); having a low level of education (OR = 1.53: 95% CI: 1.00-2.39); having severe asthma (OR = 1.65; 95% CI: 1.24-2.18); and having chronic rhinitis (OR = 2.20; 95% CI: 1.00-4.80). CONCLUSIONS In this cohort, having chronic rhinitis, having asthma that is more severe and having a low level of education were the main risk factors for ER visits due to asthma exacerbations. These results are similar to those reported for asthma patients who are receiving no regular treatment.
Understanding the influence of interpersonal relationships on identity and tourism travel

Travel plays a part in shaping the perception of self through experiences of other people and places. “Finding yourself” through travel has been widely discussed in the tourism literature; however, relatively little has been documented about how identity can influence an individual's travel choices. This paper investigates the role of interpersonal relationships in shaping identity and influencing tourism mobility. To gain insight into identity, there must be an understanding of the narratives used to create and affirm identities. A narrative interview method was used with 22 participants. The findings demonstrate how interpersonal relationships shape the self and identity which can have an impact on a tourist's travel behaviour. The analysis explores the role played by visiting friends and relatives and the impact on identity and travel. It also addresses how travel is used to enhance relationships through physical and emotional connectedness. This can lead to people undertaking travel they do not desire.
Academic Achievement of Children and Adolescents With Oral Clefts

BACKGROUND AND OBJECTIVE: Previous studies of academic achievement of children with oral clefts have mostly relied on small, clinic-based samples prone to ascertainment bias. In the first study in the United States to use a population-based sample with direct assessment, we evaluated the academic achievement of children with oral clefts relative to their classmates. METHODS: Children born with isolated oral clefts in Iowa from 1983 to 2003 were identified from the Iowa Registry for Congenital and Inherited Disorders and matched to unaffected classmates by gender, school/school district, and month and year of birth. Academic achievement was assessed by using standardized tests of academic progress developed by the Iowa Testing Programs. Iowa Testing Programs data were linked to birth certificates for all children. Regression models controlled for household demographic and socioeconomic factors. The analytical sample included 588 children with clefts contributing 3735 child-grade observations and 1874 classmates contributing 13 159 child-grade observations. RESULTS: Children with oral clefts had lower scores than their classmates across all domains and school levels, with a 5-percentile difference in the overall composite score. Children with clefts were approximately one-half grade level behind their classmates and had higher rates of academic underachievement and use of special education services by 8 percentage points. Group differences were slightly lower but remained large and significant after adjusting for many background characteristics. CONCLUSIONS: Children with oral clefts underperformed across all academic areas and grade levels compared with their classmates. The results support a model of early testing and intervention among affected children to identify and reduce academic deficits.
From combinatorial peptide selection to drug prototype (I): Targeting the vascular endothelial growth factor receptor pathway

Inhibition of blood vessel formation is a viable therapeutic approach in angiogenesis-dependent diseases. We previously used a combinatorial screening on vascular endothelial growth factor (VEGF)-activated endothelial cells to select the sequence CPQPRPLC and showed that the motif Arg-Pro-Leu targets VEGF receptor-1 and neuropilin-1. Here, we evaluated and validated D(LPR), a derivative molecule with strong antiangiogenesis attributes. This prototype drug markedly inhibits neovascularization in three mouse models: Matrigel-based assay, functional human/murine blood vessel formation, and retinopathy of prematurity. In addition to its systemic activity, D(LPR) also inhibits retinal angiogenesis when administered in an eye-drop formulation. Finally, in preliminary studies, we have showed targeted drug activity in an experimental tumor-bearing mouse model. These results show that drugs targeting extracellular domains of VEGF receptors are active, affect signal transduction, and have potential for clinical application. On a larger context, this study illustrates the power of ligand-directed selection plus retro-inversion for rapid drug discovery and development.
Are we failing clinical trials? A case for strong aggregate outcomes

Clinical trials in psychiatry inherit methods for design and statistical analysis from evidence-based medicine. However, trials in other clinical disciplines benefit from a more specific relationship between instruments that measure disease state (e.g. biomarkers, clinical signs), the underlying pathology and diagnosis such that primary outcomes can be readily defined. Trials in psychiatry use diagnosis (i.e. a categorical label for a syndrome) as a proxy for the underlying disorder, and outcomes are defined, for example, as a percentage change in a univariate total score on some clinical instrument. We label this approach to defining outcomes weak aggregation of disease state. Univariate measures are necessary, because statistical methodology is both tractable and well-developed for scalar outcomes, but we show that weak aggregate approaches do not capture disease state sufficiently, potentially leading to loss of information about response to intervention. We demonstrate how multivariate disease state can be captured using geometric concepts of spaces defined over routine clinical instruments, and show how clinically meaningful disease states (e.g. representing different profiles of symptoms, recovery or remission) can be defined as prototypes (geometric locations) in these spaces. Then, we show how to derive univariate (scalar) measures, which capture patient's relationships to these prototypes and argue these represent strong aggregates of disease state that may be a better basis for outcome measures. We demonstrate our proposal using a large publically available dataset. We conclude by discussing the impact of strong aggregates for analyses in traditional and novel trial designs.
The BB Diabetic Rat: Profound T-Cell Lymphocytopenia

Approximately 50% of Wistar “BB” rats spontaneously develop overt diabetes mellitus characterized by loss of β-cells and “insulitis. ” To define abnormalities of immunoregulation in these rats, we quantitated their major circulating lymphocyte subsets. Independent of the development of diabetes, we found the BB rats to have a markedly increased percentage of circulating B lymphocytes which is secondary to a severe T-cell lymphocytopenia, with the major circulating T-cell subset reacting with monoclonal antibody W3/25 markedlydecreased. This lymphocytopenia is present in every animal studied and contrasted with studies of the nondiabetic Wistar strain from which the “BB” rats were developed.
Adverse Local Reactions to Amethocaine Cream—Audit and Case Reports

Amethocaine has recently been introduced as a topical local anaesthetic preparation. Following sporadic reports of severe local adverse effects, we conducted an audit of 372 children attending our hospital for day surgery. We conclude that 4% amethocaine cream is a safe and effective topical anaesthetic and that the incidence of severe local adverse reactions is rare. We also report two of these local reactions, one involving occupational exposure.
Team-Based Learning in a Capstone Course in Speech-Language Pathology

Team-based learning (TBL), although found to increase student engagement and higher-level thinking, has not been examined in the field of speech-language pathology. The purpose of this study was to examine the effect of integrating TBL into a capstone course in evidence-based practice (EBP). The researcher evaluated 27 students’ understanding of EBP, perceptions of how TBL influenced their learning, and confidence that they achieved course objectives. Students’ responses on individual and group assessments, an exhaustive description, and a pre/post-course survey provided evidence of their achievement of the course objectives. Student rating and ranking of course elements indicate the perceived value of group learning and assessment. In addition, students also reported increased confidence on many of the course objectives.
Anti-Escherichia coli O157:H7 Properties of Purple Prairie Clover and Sainfoin Condensed Tannins

Condensed tannins (CT) from purple prairie clover (PPC; Dalea purpurea Vent.) and sainfoin (SF; Onobrychis viciifolia) were assessed for anti-Escherichia coli activity by comparing their ability to react with proteins and liposome, cause cell aggregation, and alter outer membrane (OM) morphology and permeability. The PPC CT had greater (P < 0.01) protein-precipitating capacity than SF CT using either bovine serum albumin or ribulose 1,5-disphosphate carboxylase as model proteins. Minimum inhibitory concentration of PPC CT for two strains of E. coli and five strains of E. coli O157:H7 was four to six times lower than that of SF CT. E. coli exposed to 10 µg/mL of both CT had higher (P < 0.05) OM permeability than controls and was greater (P < 0.05) for PPC than for SF CT. Addition of both CT at 50 and 200 µg/mL caused cell aggregation which was more evident (P < 0.05) for PPC than for SF CT. Transmission electron microscopy showed electron dense material on the cell surface when cells were exposed to 50 µg/mL of PPC CT. The greater anti-E. coli activity of PPC than SF CT was due to its enhanced ability to precipitate protein that increased OM permeability and promoted cell aggregation.
Cloud-based rehabilitation exergames system

Nowadays, a great number of patients around the world require rehabilitation programs. Virtual and augmented reality has been introduced as promising assistive tools to support the patients, allowing them to continue their recovery training by themselves. The purpose of this study is to develop an intelligent, low- cost rehabilitation gaming system using a Microsoft Kinect sensor. We have developed two goal-oriented exercises that target the rehabilitation of patients with chronic pain of the arm. These exercises include moving a ball into a net (basketball game) in the vertical plane and reaching a cup (reaching game) in the horizontal plane. In addition, accurate performance measures are provided for each exercise to quantitatively evaluate the effectiveness of the treatment plan for each patient. The implemented system has increased user motivation to participate in the rehabilitation program, accelerated the recovery of the muscles, and offered the therapists the ability to assess the patients' progress.
Worüber reden die Kunden? - Ein modelbasierter Ansatz für die Analyse von Kundenmeinungen in Microblogs

3m5. Media GmbH, Dresden Communardo Software GmbH, Dresden GI-Regionalgruppe, Dresden FERCHAU Engineering GmbH, Dresden IBM, Dresden itsax.de | pludoni GmbH, Dresden Kontext E GmbH, Dresden objectFab GmbH, Dresden queo GmbH, Dresden Robotron Datenbank-Software GmbH, Dresden SALT Solutions GmbH, Dresden SAP AG, Resarch Center Dresden Saxonia Systems AG, Dresden T-Systems Multimedia Solutions GmbH, Dresden Transinsight GmbH, Dresden xima media GmbH, Dresden
Two families of GTPases dominate the complex cellular response to IFN-gamma.

IFN-gamma induces a number of cellular programs functional in innate and adaptive resistance to infectious pathogens. It has recently become clear that the complete cellular response to IFN-gamma is extraordinarily complex, with >500 genes (i.e., approximately 0.5% of the genome) activated. We made suppression-subtractive hybridization differential libraries from IFN-gamma-stimulated primary mouse embryonic fibroblasts and from a mouse macrophage cell line, ANA-1, in each case with reference to unstimulated cells. Of approximately 250 clones sequenced at random from the two libraries, >35% were representatives of one or the other of two small unrelated families of GTPases, the 65-kDa and 47-kDa families. These families dominate the IFN-gamma-induced response in both cell types. We report here the full-length sequences of one new 65-kDa and two new 47-kDa family members. The 65-kDa family members are under transcriptional control of IRF-1, whereas the 47-kDa family members are inducible in embryonic fibroblasts from IRF-1(-/-) mice. Members of both GTPase families are strongly up-regulated in livers of wild-type mice infected with the pathogenic bacterium, Listeria monocytogenes, but not in IFN-gammaR(0/0) mice. These GTPases appear to be dedicated to the IFN-gamma response, since resting levels are negligible and since neither family shows any significant relationship to any other described family of GTPases. Understanding the role of these GTPases in IFN-gamma-mediated resistance against pathogens is the task for the future.
Towards the automatic design of decision tree induction algorithms

Decision tree induction is one of the most employed methods to extract knowledge from data, since the representation of knowledge is very intuitive and easily understandable by humans. The most successful strategy for inducing decision trees, the greedy top-down approach, has been continuously improved by researchers over the years. This work, following recent breakthroughs in the automatic design of machine learning algorithms, proposes two different approaches for automatically generating generic decision tree induction algorithms. Both approaches are based on the evolutionary algorithms paradigm, which improves solutions based on metaphors of biological processes. We also propose guidelines to design interesting fitness functions for these evolutionary algorithms, which take into account the requirements and needs of the end-user.
Why Crime Rates Are Falling throughout the Western World

Crime rates have moved in parallel in Western societies since the late Middle Ages. Homicide rates declined from 20 to 100 per 100,000 population in western Europe to one per 100,000 in most Western countries by the beginning of the twentieth century. Crime rates in major cities and in countries fell from the early nineteenth century until the middle of the twentieth. From the 1960s to the 1990s, rates for violent and property crimes rose in all wealthy Western countries. Since then, rates in all have fallen precipitately for homicide, burglary, auto theft, and other property crimes. The patterns appear in both police and victimization data. Rates for nonlethal violence have fallen sharply in the English-speaking countries and parts of continental Europe. In other parts of Europe, nonlethal violence has been stable or increasing, but the data are probably wrong. Interacting changes in rates of reporting and recording and in cultural thresholds of tolerance of violence that occurred earlier in the English-speaking countries are the likeliest explanation for the appearance of crime rate increases. Diverse explanations have been offered for both the long- and short-term declines. Most agree that, whatever the explanations may be, they do not include direct effects of changes in policing or sanctioning policies.
Features of interventions that appear to result in positive impact in treatment of children with autism

Features of interventions that appear to result in positive impact in treatment of children with autism Herbert M. Turner III & Chad Nye (Commentary authors), Graduate School of Education, University of Pennsylvania, Philadelphia, PA, USA and University of Central Florida, Department of Communication Sciences and Disorders and Center for Autism & Related Disabilities, Orlando, FL, USA .
Dialogues between Academics and Practitioners: The Role of Generative Dialogic Encounters

In this paper we seek to show how aspects of the thinking underpinning the relevance debate can be self-defeating. We consider the relationship between academics and practitioners from a dialogic perspective and perform a textual analysis of the ways in which ‘pro-relevance’ academics write about research. We use role analysis techniques to highlight the potential for mismatched expectations between academics and practitioners, and then consider an illustrative dialogue between practitioners and academics to develop our view that relevance has its roots in generative dialogic encounters. We conceptualize a modified view of dialogue in the context of organizational research relationships, which we believe offers a useful starting point for co-production of knowledge and understanding.
Salmochelins, siderophores of Salmonella enterica and uropathogenic Escherichia coli strains, are recognized by the outer membrane receptor IroN

Members of a family of catecholate siderophores, called salmochelins, were isolated by reversed-phase HPLC from Salmonella enterica serotype Typhimurium and structurally characterized by Fourier transform ion cyclotron resonance–MS/MS and GC–MS. The tentative structure of salmochelin 1 contained two 2,3- dihydroxybenzoylserine moieties bridged by a glucose residue, bound to the serine hydroxyl group of one moiety and the carboxylate of the second moiety. Salmochelin 2 contained in addition a second glucose residue linked to a third 2,3-dihydroxybenzoylserine moiety. Salmochelins were not produced by an iroBC mutant, which indicated that the IroB protein might be responsible for the glucosyl transfer predicted by sequence similarities to known glycosyltransferases. Uptake experiments with radiolabeled 55Fe-salmochelin and growth promotion tests with salmochelins showed that the IroN outer membrane receptor, encoded in the iroA locus of S. enterica and uropathogenic Escherichia coli strains, was the main receptor for ferric salmochelin transport.
APPLYING SITUATED COGNITIVE ENGINEERING FOR PLATFORM AUTOMATION IN THE 21 st CENTURY

Technical crews on board of modern naval vessels need excellent support to maximize performance under a large variety of circumstances. The drive to save costs and reduce manning even increases the need for such support systems. Future Dutch naval ships include ship control centers which are manned depending on the status of ship and system. This new way of working not only sets new requirements for the technical system, but it also sets new requirements for the human operations and the corresponding operator capacities. This human aspect has been insufficiently addressed during all development and implementation phases of our current ships. ‘Old’ design and ship building methods, including the way industrial partners are involved, can’t answer these questions completely. This paper presents a new cognitive engineering method, consisting of three important parts. The first part is the analysis of operational demands, human factor knowledge and envisioned technology. In the second part requirements are specified for the three mentioned areas of the first stage, using scenarios, claims and core functions. The third part consists of reviewing and testing to refine the requirements in iterative loops. The method has been applied and shows how it can improve ship design for two future Dutch ships.