Miracle-dz/UniFAR-FTUs huggingface dataset:
Derating for static timing analysis: Theory and practice

Derating is a versatile technique supported by all static timing analysis (STA) tools in industry. In essence, it enables designers to modify any delay or slew computation performed by such tools. Despite this common use in industry, the scientific literature on derating is scarce to none. This has led to its incorrect use, misunderstanding, and even dismissal. This situation has also been exacerbated with the emergence of statistical STA. This paper is our attempt to fill this void in the literature. We review the use of derating in the context of STA, discuss the important issues, and provide answers to its correct use. We also provide experimental results to justify our claims. Our contribution builds a theoretical and practical foundation to help designers get more insight into derating.
Development and evaluation of a point-of-care interactive patient education kiosk

We have developed an interactive patient education kiosk. The kiosk provides access to stored health information and to selected Websites via a high-speed Internet connection. The output is bilingual (English or Spanish) and an enclosed printer allows information to be printed and taken home for later reading. Each kiosk records patient usage, as well as the results of a brief, voluntary, online evaluation questionnaire. Three kiosks were placed in the patient waiting area of busy multi-specialty clinics. Two kiosks were active for 2.5 years and one was active for 1.5 years. There were 38,868 user sessions recorded and 2878 users participated in the online survey questionnaire (7% of all user sessions). Patient satisfaction was high; for example, 68% of respondents found some or all of the information they were looking for on the kiosk. In the year following the introduction of the first kiosk (the 2001/02 flu season), there was a 24% increase in the number of patients receiving flu vaccinations within the Palo Alto health-care system, compared with the previous year. Experience to date suggests that the kiosks may increase patient compliance with selected clinical guidelines and instructions.
Use of Escherichia coli operon-fusion strains for the study of glycerol 3-phosphate transport activity

Strains of Escherichia coli K-12 deleted in the native lac operon and bearing both a wild-type glpT operon encoding for sn-glycerol 3-phosphate (G3P) transport and a hybrid operon in which glpT operator and promoter regions are fused to the lacZ gene were constructed. In strains with such a hybrid operon, beta-galactosidase and beta-galactoside permease become inducible by G3P. In these mutants the function and maturation of the glpT-coded proteins should be distinguishable from the level of gene expression, since the beta-galactosidase activity can serve as an index of the latter. With the aid of such mutants, it was shown that: (i) the expressions of the two neighboring operons, glpT and glpA (encoding anaerobic G3P dehydrogenase), are not coordinate; (ii) upon induction, the appearance of the cytoplasmic beta-galactosidase activity preceded that of methyl-beta-D-thiogalactoside transport activity (requiring only a cytoplasmic membrane protein) by about 4 min and that of G3P transport activity (requiring both a cytoplasmic membrane protein and a periplasmic protein) by about 9 min; and (iii) when cells grown at several temperatures from 24 to 42 degrees C were measured for G3P transport activity at 30 degrees C, the activity increased with the growth temperature, indicating that, within the range studied, the rate of transport increases with the fluidity of membrane phospholipids.
The relationships among tourism development, energy demand, and growth factors in developed and developing countries

The objective of the study is to explore the different factors that affect tourism development in the panel of 34 developed and developing countries, over the period of 2005–2013. Energy consumption, air pollution, health expenditures, and economic growth played a vital role to change tourism development indicators in the region. The results confirmed the long-run association between the energy, environment, growth, and tourism indicators in the panel of selected 34 countries. The results of fully modified ordinary least squares (FMOLS) indicate that health expenditures have a positive relationship with the tourism indicators, while energy consumption exerts a negative association with the tourism indicators in the region. The results of dynamic ordinary least squares regression also confirmed the same results of FMOLS regarding health expenditures and energy consumption, that is, positive and negative impacts on the tourism indicators. However, carbon dioxide emissions exert a positive relationship with the tourism indicators in the region.
Identification of Physiological Substrates and Binding Partners of the Plant Mitochondrial Protease FTSH4 by the Trapping Approach

Maintenance of functional mitochondria is vital for optimal cell performance and survival. This is accomplished by distinct mechanisms, of which preservation of mitochondrial protein homeostasis fulfills a pivotal role. In plants, inner membrane-embedded i-AAA protease, FTSH4, contributes to the mitochondrial proteome surveillance. Owing to the limited knowledge of FTSH4’s in vivo substrates, very little is known about the pathways and mechanisms directly controlled by this protease. Here, we applied substrate trapping coupled with mass spectrometry-based peptide identification in order to extend the list of FTSH4’s physiological substrates and interaction partners. Our analyses revealed, among several putative targets of FTSH4, novel (mitochondrial pyruvate carrier 4 (MPC4) and Pam18-2) and known (Tim17-2) substrates of this protease. Furthermore, we demonstrate that FTSH4 degrades oxidatively damaged proteins in mitochondria. Our report provides new insights into the function of FTSH4 in the maintenance of plant mitochondrial proteome.
Nucleosomes, ProGRP, NSE, CYFRA 21-1, and CEA in Monitoring First-Line Chemotherapy of Small Cell Lung Cancer

Purpose: Besides new therapeutic drugs, effective diagnostic tools indicating early the efficacy of therapy are required to improve the individual management of patients with nonoperable cancer diseases. Experimental Design: In prospectively collected sera of 128 patients with newly diagnosed small cell lung cancer receiving first-line chemotherapy, the courses of nucleosomes, progastrin-releasing peptide (ProGRP), neuron-specific enolase (NSE), cytokeratin-19 fragments (CYFRA 21-1), and carcinoembryonic antigen were investigated and correlated with therapy response objectified by computed tomography before start of the third treatment course. Results: In univariate analyses, high levels and insufficient decreases of nucleosomes, ProGRP, NSE, and CYFRA 21-1 during the first and second cycles of therapy correlated with poor outcome. Insufficient response to therapy was most efficiently indicated by the baseline values of nucleosomes, ProGRP, and CYFRA 21-1 before the second therapy cycle reaching areas under the curve (AUC) of 81.8%, 71.3%, and 74.9% in receiver operating characteristic curves, respectively. Combinations of nucleosomes with ProGRP (AUC 84.1%), CYFRA 21-1 (AUC 82.5%), and NSE (AUC 83.6%) further improved the diagnostic power in the high specificity range and yielded sensitivities of 47.1%, 35.3%, and 35.3% at 95% specificity, respectively. In multivariate analyses, including clinical and biochemical variables, only performance score and nucleosomes before cycle 2 were found to independently indicate therapy response. Conclusions: Biochemical markers specifically identified patients with insufficient therapy response at the early treatment phase and showed to be valuable for diseases management of small cell lung cancer.
Patch antennas with superstrates for landmine detection

In this paper, a new technique for anti-personnel landmine detection is proposed. A high gain single microstrip antenna is used to detect the presence of a standard landmine buried in dry sand. A superstrate layer made of Al2O3 ceramic is used to increase the antenna gain and consequently increase the detection sensitivity. The change in the phase of the antenna's reflection coefficient (S11) is used as an evident of the landmine existence. A phase difference of 106.42 degrees was observed using the proposed detection system. The system is analyzed using ANSYS HFSS.
Enhancing effect of intracerebrally infused beta-endorphin antiserum on the secretion of cortisol in foot-shocked sheep.

It was found in our earlier experiments that infusion of beta-endorphin (beta-End) into the 3rd brain ventricle in sheep elicited a differential effect on the secretion of cortisol under physiological and stress conditions. Under physiological conditions it elevated the level of cortisol in the peripheral blood, while in stressed animals it suppressed it. To obtain further support for the suppressive action of beta-End on cortisol secretion under stress conditions a beta-End antiserum was infused into the 3rd ventricle of the brain in stressed and nonstressed sheep and the concentration of plasma cortisol was measured. Stress was induced by mild electric foot shock. Infusion of the beta-End antiserum during stimulation enhanced the plasma cortisol values, when compared with those obtained during the infusion of rabbit hyperimmune serum containing anti-guinea pig gamma-globulins or saline. Moreover, during the infusion of beta-End anti-serum some aggravation of stress symptoms expressed by the increase of restlessness and higher frequency of defecations and urinations was observed. Additional experiments carried out to study the effect of beta-End on prolactin (PRL) secretion showed that this opioid induced a very high secretion of PRL in stressed animals. On the basis of these data and the known suppressive action of PRL on the corticosterone response to stress in the rat, we suggest that the suppressive action of beta-End on cortisol secretion in stressed sheep could be caused by the action of PRL. (ABSTRACT TRUNCATED AT 250 WORDS)
Audiences at the Heart of the IPCC: Exploratory Research Into the IPCC's Communications

In 2010, the Intergovernmental Panel on Climate Change adopted a formal strategy to make its communications available and accessible for audiences beyond its primary audience of governments and policymakers. By means of interviews with prominent climate change communicators in the United Kingdom, the needs of its secondary audiences (e.g., NGOs, journalists, general public) are explored with reference to core elements of every communication process. The results show that the IPCC currently applies an outdated model of science communication. There is room for improvement. The present research produced 11 recommendations for the IPCC to communicate more effectively to its multiple audiences.
Choquet integral regression model based on high-order L-measure

The well known fuzzy measures, λ-measure and P-measure, have only one formulaic solution, the former is not a closed form, and the later is not sensitive. An improved multivalent fuzzy measure with infinitely many solutions of closed form, called L-measure, is proposed by our previous work. In this paper, expend the L-measure for being more choice, and get an improved fuzzy measures, called “hth-order L-measure”, denoted as Lh-measure, and a new Choquet integral regression model based on this Lh-measure is also proposed. For evaluating the proposed regression models with different fuzzy measures, a real data experiment by using a 5-fold cross-validation mean square error (MSE) is conducted. The performances of Choquet integral regression models with fuzzy measure based on λ-measure, P-measure, L-measure and Lh-measure, respectively, a ridge regression model, and a multiple linear regression model are compared. Experimental result shows that the Choquet integral regression models with Lh-measure based on γ-support outperforms others forecasting models.
Topical treatment of genital warts in men, an open study of podophyllotoxin cream compared with solution.

OBJECTIVE--To evaluate the clinical efficacy of a 0.15% and a 0.3% cream formulation of podophyllotoxin in comparison with the 0.5% solution in the treatment of condylomata acuminata and to compare the treatment modalities regarding side effects. DESIGN--The study was designed as an open randomised trial. Ninety male patients with signs of penile HPV infection, with either acuminate or papular lesions, were randomised into three parallel treatment groups. The study medication comprised 0.15% and 0.3% cream and 0.5% solution of podophyllotoxin. The patients treated themselves twice daily for three consecutive days and if total regression of the warts was not achieved after this first treatment cycle, further treatment cycles at 7-day intervals were to be repeated up to a maximum of four treatments. SETTING--The study was carried out in three outpatient clinics: two STD clinics, Department of Dermatology and Venereology, University Hospital (45 patients) and Institut Antoine Fournier, Paris (30 patients), and one military hospital, S1/FO 47/48, Sjukhusenheten, Enköping (15 patients). RESULTS--Statistical evaluation of the treatment effect was based on a "Response rate" calculation at each visit. The number of completely responding patients after the first, second, third and fourth cycle were 40 (44%), 61 (68%), 67 (74%) and 70 (78%), respectively. There was no statistically significant difference between the three treatments after four treatment cycles. However, the 0.15% cream had a significantly slower onset of efficacy as compared with the 0.3% cream and 0.5% solution. Adverse effects were less severe and less frequent with the 0.15% cream than with the other treatment modalities. Severe adverse effects were reported by 12 patients, of whom two were treated with 0.15% cream, five with 0.3% cream and five with 0.5% solution. Thirty-one patients were completely free from adverse effects. CONCLUSION--In this open randomised study with three parallel treatment groups, two cream formulations of 0.15% and 0.3% podophyllotoxin and a 0.5% solution of the same drug all showed an equally good response rate after four treatment cycles. Reported adverse effects were few and mild. The convenience of having different formulations to offer when prescribing treatment for condylomata must be considered.
Paclitaxel and carboplatin combination chemotherapy in a hemodialysis patient with advanced ovarian cancer.

BACKGROUND There are few reports on the pharmacokinetics of paclitaxel combined with carboplatin or on the dose schedule of carboplatin in combination use during hemodialysis in patients with ovarian cancer. CASE A 40-year-old woman with chronic renal failure on hemodialysis who had FIGO stage III ovarian cancer was treated with debulking surgery and carboplatin/paclitaxel combination chemotherapy. Paclitaxal was administered at 150 mg/m(2) as a 3-h intravenous infusion followed by a 30-min infusion of carboplatin on a nondialysis day. The carboplatin dose was chosen to produce a target area under the concentration/time curve (AUC) of 5.0 microg-min/ml according to the Calvert formula. The pharmacokinetic study showed that the AUCs of free platinum and paclitaxel were 4.43 microg-min/ml and 15.9 microg-h/ml, respectively. Dosing of carboplatin based on the AUC produced an acceptable degree of thrombocytopenia and neutropenia. After the completion of five cycles of the combination chemotherapy, the tumor showed complete response, and the patient remained disease free for 8 months. CONCLUSION Paclitaxel and carboplatin combination chemotherapy can be given to patients undergoing hemodialysis, with dialysis performed 16 h after the administration and with a dose adjustment of carboplatin to reach a target AUC. In these conditions, tumor response can be obtained.
Morphometric Evaluation of the Cervico‐Thoracic Junction: Practical Considerations for Posterior Fixation of the Spine

Study Design Linear and angular measurements were performed on 128 vertebrae (16 spines) from C5 to T5. Objectives Vertebrae were studied to characterize vertebral shape and size changes in the cervico-thoracic region. Summary of Background Data Analysis of vertebral anatomy has been extensive and well characterized. Regions of transitional anatomy necessitate further study due to the often abrupt changes in anatomic relationships. Methods Two observers performed linear and angular measurements including pedicle width, height, and length, as well as a pedicle-body, pedicle-lamina, lamina-transverse process, and pedicle-lamine angular measurements. Pedicle axis projection on the posterior aspect of the lamina was also calculated. Results The mean pedicle width ranged from 7.8 mm (T1) to 4.4 mm (T5). The body-pedicle angle decreased >4 degrees per level in the transverse plane, from 50° (C5) to 11° (T5). The axial projection of the pedicle changed throughout the region (compared with level above) and was significant for T1. Conclusions Because of the complexities of the cervico-thoracic junction, additional characterization increases the knowledge of the anatomic relationships in this region.
BALKAN ENDEMIC NEPHROPATHY IN SERBIA: CURRENT STATUS AND FUTURE RESEARCH

Summary. During the 90s, wars and economic hardship hampered most attempts for serious research in Serbia, as well as in other BEN affected countries. This relative lull in intensive research provided an opportunity for identifying key problems and assessing priorities for future research. The following issues were singled out as relevant from this point of view: 1. What is the trend of BEN? Did it disappear? 2. Is exposure to the agent(s) still going on? 3. Which descriptive epidemiological features of BEN may be considered established and how they should be interpreted? 4. What are the most likely aetiological hypotheses to be pursued? 5. Assuring a proper study design. 6. Avoiding “circular” research. 7. Conducting transregional studies. 8. Ethical considerations. This first scientific meeting on BEN after more than a decade is an important opportunity to agree on priorities, establish interregional collaboration and proceed with research at an internationally acceptable and competitive level.
Differential affinities of MinD and MinE to anionic phospholipid influence Min patterning dynamics in vitro

The E. coli Min system forms a cell‐pole‐to‐cell‐pole oscillator that positions the divisome at mid‐cell. The MinD ATPase binds the membrane and recruits the cell division inhibitor MinC. MinE interacts with and releases MinD (and MinC) from the membrane. The chase of MinD by MinE creates the in vivo oscillator that maintains a low level of the division inhibitor at mid‐cell. In vitro reconstitution and visualization of Min proteins on a supported lipid bilayer has provided significant advances in understanding Min patterns in vivo. Here we studied the effects of flow, lipid composition, and salt concentration on Min patterning. Flow and no‐flow conditions both supported Min protein patterns with somewhat different characteristics. Without flow, MinD and MinE formed spiraling waves. MinD and, to a greater extent MinE, have stronger affinities for anionic phospholipid. MinD‐independent binding of MinE to anionic lipid resulted in slower and narrower waves. MinE binding to the bilayer was also more susceptible to changes in ionic strength than MinD. We find that modulating protein diffusion with flow, or membrane binding affinities with changes in lipid composition or salt concentration, can differentially affect the retention time of MinD and MinE, leading to spatiotemporal changes in Min patterning.
Capacity estimation of VoIP transmission over WLAN

Today's IEEE 802.11 wireless local area network (WLAN) is an excellent solution for the broadband wireless networking. However, the legacy protocol lacks the capability to support real-time services such as Voice over IP (VoIP) properly because it depends on the best effort service. New IEEE 802.11e protocol can support QoS. This paper presents the VoIP stations capacity in IEEE 802.11 WLAN and IEEE 802.11e WLAN via computer simulation. Additionally new access category parameter is suggested to enhance the VoIP capacity in 802.11e WLAN.
The Complex Quantum-State of Black-Hole and Thermostatistics.

In this paper the quantum aspects are described in-detail with the help of a new type of energy source called latent energy group SU(6) of the super unified theory of SU(11). The thermodynamics of general self gravitating systems created by the energy group SU(6) and some related topics such as complex space-time (i.e. Pseudo-Space-Time) are also briefly discussed. The thermodynamic connection is based on Hawking celebrated application of quantum theory to Black-Hole. We know that macroscopic systems have definite and precise energies, subject to definite conservation principle. In this paper the generalized theory of black-hole is examined in-detail. We study the quantum state of black-hole. We consider our universe begins through the symmetry breaking of the super unified theory with gauss group SU(11) (  SU(6)  SU(5)  U(1)) from 7-dimensionsl space-time. The subgroup SU(6) has been interpreted as a new type of energy source other than SU(5) (SU(5)  SU (3)  SU(2)  U(1), where SU(3), the strong energy group, SU(2) the weak-energy group and U(1), the electro-dynamics). The energy group SU(6) are responsible for the situation of the so-called black-hole and U(1), also for the creation of Schwarzschild mass 'M' and angular momentum 'J', as U(1) are responsible for the creation of electric charge 'e' ( where M & J- depends on 'e' as shown in this paper ). We consider the line element proposed by the quantum-vacuum Kantowski-Sachs universe without cosmological constant. We also consider the scale factor b(= iR) of the metric to be imaginary and the other a( = R) is real, of the Kantowski-Sachs quantum-state with complex space- time. Solving the metric tensors we get the energy tensors in the 10(= 4+6) dimensional spacetime under the exchange RI ↔ R. We think from 10-dimensional to 7-dimensional stage, the situation of primordial black-hole formed by the energy group SU(11). The fact is obviously defined within 10- dimensional to7-dimensional flat universe and then the black-hole formed within 7-dimensional to 4- dimensional closed universe through the symmetry breaking of the energy group SU(11), the negative pressure by is define the matter energy density and is define the latent energy density. At the early stage The universe then begins its journey through the phase transition system.