Miracle-dz/UniFAR-FTUs huggingface dataset:
Self-consistent simulation of supersonic plasma flows in advanced divertors

Advanced divertors gain larger plasma wetted area by poloidal or total flux expansion. Qualitative characteristics of supersonic plasma flows which are generated by the magnetic nozzle effect are studied by using a plasma fluid model incorporating anisotropic ion pressure (AIP model). The AIP model can self-consistently simulate supersonic plasma flows because, unlike the widely-used plasma fluid model (the Braginskii equations), the equation of parallel plasma momentum in it is described as a hyperbolic-type and the plasma flow velocity is solved without using explicit boundary conditions at the sheath entrance in front of divertor plates. In comparisons of plasma profiles between the AIP model and the Braginskii equations, it is observed that the plasma flow velocity in the Braginskii equations is forced to the sound speed at the sheath entrance in conditions of decelerating supersonic plasma flows leading to qualitative deviations with the AIP model. In an application of the AIP model to a scrape-off layer/divertor region incorporating super-X divertors with various flux-expansion ratios, supersonic plasma flows in divertor regions and highly anisotropic ion temperatures are successfully simulated. It is also demonstrated that it becomes easier with the AIP model to explain the mechanisms of generations of supersonic plasma flows and acceleration/deceleration of them (including stationary shock waves) in flux-expanding divertors from the mirror effect point of view.
[The diagnosis, treatment and prognosis evaluation of gastric small cell carcinoma: analysis of 41 cases].

OBJECTIVE To summarize and analyze the clinical feature, therapeutic methods and prognosis of gastric small cell carcinoma (SCC). METHODS The clinical and pathological data of 41 patients diagnosed of gastric SCC were analyzed in this research. Also, the factors which may potentially affect the patients' survival outcome were evaluated. There were 35 male and 6 female patients. The age at diagnosis was 39-84 years, median age was 62 years. The 31 cases (75.6%) of gastric SCC patients were involved in the upper third of the stomach, 3 cases (7.3%) in the middle, 7 cases (17.1%) in the lower third. RESULTS The time from the event of symptoms to final confirmation was 1 to 13 months, the median time was 3 months. The longest diameter of tumors was from 2.5 to 15.0 cm, the average was 6.5 cm. The 38 cases (92.7%) chosed surgery as the first treatment, among which 25 cases (61.0%) were performed radical tumor resection, 13 cases (31.7%) went through palliative resection, and 3 cases (7.3%) just employed chemotherapy. The initial II, III, IV stage were 2, 31 and 8 cases, respectively. The overall median survival time was 19 months, median disease free survival time was 11 months, 1-, 2-, 5-years survival rates were 70.7%, 46.3% and 36.6%, respectively. In univariate survival analysis, the tumor size (χ² = 5.565), change of the body weight (χ² = 3.688), type of operation (χ² = 11.747) and relapse or not (χ² = 17.966) were obviously correlaed with the prognosis (P < 0.05). CONCLUSIONS Gastric SCC is a rare disease of the gastrointestinal tract, the misdiagnosis rate is high, and the prognosis is dismal. Muti-modality management, with radical surgical resection of the primary lesion followed by standard adjuvant-chemotherapy, affords better local disease control and a better survival outcome.
Regional Consumer Price Differences Within Germany

Summary Every month the Consumer Price Index for Germany (CPI) provides comprehensive and detailed information regarding the price development over time. However, when differences in the price level across regions in Germany have to be analysed at a given point in time, sufficient information is not available at present. Interest in regional consumer price data is shown by both scientists and policy makers. Currently, this information demand is not met as regional consumer prices or regional price comparisons are not provided by the Federal Statistical Office in Germany. Data available from the German Consumer Price Index is suitable to follow the price development over time but cannot be used directly to compare price levels of different regions because the goods tracked may be different from region to region. The article first considers the information demand and gives an overview of existing price data. Its main part refers to an empirical study which was conducted to check if existing Consumer Price Index data can be used to calculate regional consumer price comparisons by ex-post selecting comparable products.
Clinical efficacy of antiretroviral combination therapy based on protease inhibitors or non-nucleoside analogue reverse transcriptase inhibitors: indirect comparison of controlled trials

Abstract Objective To compare the clinical efficacy of triple antiretroviral regimens based on protease inhibitors and non-nucleoside analogue reverse transcriptase inhibitors (NNRTIs) in adults positive for antibodies to HIV-1. Design Systematic review and meta-analysis using indirect comparisons of clinical trials comparing three drug regimens based on two nucleoside reverse transcriptase inhibitors (NRTIs) and either a protease inhibitor or an NNRTI with two drug regimens (two NRTIs). Participants had no previous exposure to protease inhibitors or NNRTIs. Data sources Medline, the Cochrane controlled trials register, Aidstrials, Aidsdrugs, conference proceedings, and trial registers. Main outcome measure Progression to AIDS or death. Results 14 trials, totalling 6785 patients, were identified. Most patients had been exposed to an NRTI and had advanced immunodeficiency at baseline; 1096 progressed to AIDS or died. Seven trials assessed protease inhibitors based triple regimens and seven assessed NNRTI based triple regimens (nevirapine or delavirdine). Triple therapy was more effective than dual therapy. The effect was pronounced for protease inhibitor based regimens (odds ratio 0.49, 95% confidence interval 0.41 to 0.58) but non-significant for NNRTI based regimens (0.90, 0.71 to 1.15). Indirect comparison of the two regimens gave an odds ratio of 0.54 (0.49 to 0.73) in favour of protease inhibitor based treatments. Increases in CD4 cell counts were smaller and suppression of viral replication less with NNRTI based regimens. Conclusions Indirect evidence shows that protease inhibitor based triple regimens are superior to regimens based on the NNRTIs nevirapine and delavirdine in patients with advanced immunodeficiency who have been exposed to NRTIs. Large trials with clinical end points are required.
Effect of education intervention on the quality and long-term outcomes of root canal treatment in general practice.

AIM To compare the technical quality and long-term outcomes of root canal treatment by general practitioners of a Swedish Public Dental Service, before and after an endodontic education including Ni-Ti rotary technique (NiTiR). METHODOLOGY A random sample was compiled, comprising one root filled tooth from each of 830 patients, treated by 69 general practitioners participating in the education: 414 teeth root filled in 2002, pre-education, using primarily stainless steel instrumentation and filling by lateral compaction, and 416 teeth root filled post-education (2005), using mainly NiTiR and single-cone obturation. Follow-up radiographs taken in 2009 were evaluated alongside immediate post-filling radiographs from 2002 to 2005. The density and length of the root fillings were registered. Periapical status was assessed by the Periapical Index (PAI), using two definitions of disease: apical periodontitis (AP) (PAI 3 + 4 + 5) and definite AP (PAI 4 + 5). Tooth survival was registered. Root fillings pre- and post-education were compared using chi-square and Fisher's exact tests. Crude extraction rates per 100 years were calculated for comparison of tooth survival. Explanatory variables (type of tooth, root filling quality, periapical status, marginal bone loss, type and quality of coronal restoration) in relation to the dependent variable (AP at follow-up) were analysed by multivariable logistic regression. RESULTS Follow-up data were available for 229 (55%) of teeth treated pre- and 288 (69%) treated post-education: both tooth survival (P < 0.001) and root filling quality were significantly higher (P < 0.001) in the latter. However, there was no corresponding improvement in periapical status. Both pre- and post-education, root fillings with definite AP on completion of treatment had significantly higher odds of AP or definite AP at follow-up. For teeth treated post-education, inadequate root filling quality was significantly associated with AP at follow-up. CONCLUSIONS Despite a higher tooth survival rate and a significant improvement in technical quality of root fillings after the education, there was no corresponding improvement in periapical status.
Recurrent symptoms after shoulder instability repair: direct MR arthrographic assessment--correlation with second-look surgical evaluation.

PURPOSE To retrospectively determine the accuracy of direct magnetic resonance (MR) arthrography of the shoulder in patients with recurrent or residual signs and/or symptoms of instability after prior instability repair, with surgical findings as the reference standard. MATERIALS AND METHODS After institutional ethics review board approval was obtained and informed consent was waived, 40 patients (31 men, eight women; mean age, 28 years) with recurrent instability after previous instability repair who underwent direct shoulder MR arthrography before repeat surgery were studied. Two musculoskeletal radiologists reviewed direct MR arthrographic studies by using consensus agreement in a blinded fashion. MR assessment included evaluation of the labrum (overall, superior, anterior and anteroinferior, posterior and posteroinferior), rotator cuff, biceps tendon, articular cartilage, and presence or absence of a Hill-Sachs lesion. Mean interval between MR arthrography and repeat surgery was 6.2 months (range, 6 days to 36 months). Surgical reports were compared with MR arthrographic results, and accuracy, sensitivity, and specificity of direct MR arthrography were determined. RESULTS Accuracy, sensitivity, and specificity, respectively, of direct MR arthrography in diagnosis of overall labral tears (n = 26) were 91.9%, 96.2%, and 81.8%; those of superior labral tears (n = 16) were 89.2%, 93.8%, and 85.7%; and those of anteroinferior tears (n = 17) were 91.9%, 100%, and 85%. Overall accuracy for detecting rotator cuff injury (n = 17) was 87.2% (sensitivity, 94.1%; specificity, 81.8%); accuracy for biceps injury (n = 7) was 95.7% (sensitivity, 85.7%; specificity, 100%); accuracy for glenoid and/or humeral articular cartilage abnormality (n = 15) was 76.2% (sensitivity, 73.3%; specificity, 83.3%); and accuracy for Hill-Sachs lesion (n = 14) was 93.3%. CONCLUSION Direct MR arthrography is accurate (91.9%) for assessing labral pathologic conditions and other internal derangements of the shoulder in patients with recurrent or residual signs and/or symptoms after prior shoulder instability repair.
Design for Reliability: The Case of Fractional-Slot Surface Permanent-Magnet Machines

Surface permanent-magnet machines are widely used in different applications, from industrial automation to home appliance and electrical traction. Among any possible machine topology, the fractional-slot surface permanent-magnet one has gained increasing importance, because of its high torque density, low cogging torque, extended flux weakening capability and high efficiency. In addition, fractional-slot machines are attractive for tooth concentrated windings, which allow some optimized manufacturing solutions such as modular stator tooth and high slot filling factor, which result in copper volume reduction; cost reduction, and lower stator parasitic resistances. The slot–pole combination is one of the most important design parameter and, as shown in this paper, it affects performances and the robustness of the machine with respect to the manufacturing imperfections. In the literature, slot–pole combinations are optimized at design phase by finite-element analysis relying on a healthy machine model. The original contribution of this paper is a design for reliability method that models manufacturing defects and includes them at design phase in the optimization process of slot–pole combinations. A method is presented that allows defining the optimal design parameters for maximum performances and robustness towards unavoidable imperfections caused by tolerances of the manufacturing process.
An Estimator of Solar Irradiance in Photovoltaic Arrays With Guaranteed Stability Properties

Photovoltaic cells are characterized via a static relationship that describes their current-voltage relationship. This relationship is a complicated implicit algebraic equation that depends, in a nonlinear way, on two critical uncertain parameters: temperature and solar irradiance. The efficient operation of the panel relies on the knowledge of these key parameters. While it is technologically feasible to measure the former, a sensor for the latter is usually expensive and difficult to calibrate. In this paper, we propose a globally convergent estimator for solar irradiance which is developed using the principles of immersion and invariance recently reported in the control literature. To design the estimator, a suitable reparameterization of the current-voltage characteristic, which effectively exhibits a monotonic behavior, is introduced. The approach is validated through detailed computer simulations and experimental prototyping using real outdoor measurements.
Subunit structure of the nonactivated human estrogen receptor.

The nonactivated estrogen receptor of human MCF-7 mammary carcinoma cells was investigated with respect to stoichiometry of protein subunits. The native receptor complex stabilized by molybdate had a molecular mass of approximately 300 kDa. Chemical cross-linking with several bifunctional reagents resulted in complete stabilization of the same receptor form of approximately 300 kDa and was achieved both in cell extracts and in intact cells. Incubation of the cross-linked receptor with a receptor-specific monoclonal IgG1 antibody increased the molecular mass by approximately 135 kDa--i.e., no more than one immunoglobulin molecule bound to the complex. Partial and progressive cross-linking of affinity-labeled receptors revealed patterns of labeled bands upon denaturing gel electrophoresis indicative of a heteromeric structure. The completely cross-linked receptor was purified to homogeneity and analyzed for protein components. In addition to the receptor polypeptide of approximately 65 kDa, we detected the heat shock proteins hsp90 and p59; the hsp90 band was roughly twice as intense as the p59 band. The heat shock protein hsp70 and the 40-kDa cyclophilin were not detected as components of the highly purified cross-linked receptor of approximately 300 kDa. We suggest a heterotetrameric structure consisting of one receptor polypeptide, two hsp90 molecules, and one p59 subunit, for which the molecular mass adds up to approximately 300 kDa. Thus, the nonactivated estrogen receptor has a molecular architecture homologous to those of glucocorticoid and progesterone receptors, even though phylogenetically the estrogen receptor gene forms a distinct subgroup within the gene family of nuclear hormone receptors.
Beta-blockers are associated with reduced risk of myocardial infarction after cocaine use.

STUDY OBJECTIVE Beta-blocker use is associated with coronary artery spasm after cocaine administration but also decreases mortality in patients with myocardial infarction or systolic dysfunction. We conduct a retrospective cohort study to analyze the safety of beta-blockers in patients with positive urine toxicology results for cocaine. METHODS The cohort consisted of 363 consecutive telemetry and ICU patients who were admitted to a municipal hospital and had positive urine toxicology results for cocaine during a 5-year period (307 patients). Fifteen patients with uncertain history of beta-blocker use before admission were excluded. The primary outcome measure was myocardial infarction; secondary outcome measure was inhospital mortality. Logistic regression analysis using generalized estimating equations models and propensity scores compared outcomes. RESULTS Beta-blockers were given in 60 of 348 admissions. The incidence of myocardial infarction after administration of beta-blocker was significantly lower than without treatment (6.1% versus 26.0%; difference in proportion 19.9%; 95% confidence interval [CI] 10.3% to 30.0%). One of 14 deaths occurred in patients who received beta-blockade (incidence 1.7% versus 4.5% without beta-blockade; difference in proportion 2.8%; 95% CI -1.2% to 6.7%). Multivariate analysis showed that use of beta-blockers significantly reduced the risk of myocardial infarction (odds ratio 0.06; 95% CI 0.01 to 0.61). CONCLUSION In our cohort, administration of beta-blockers was associated with reduction in incidence of myocardial infarction after cocaine use. The benefit of beta-blockers on myocardial function may offset the risk of coronary artery spasm.
Alleviating Through-Silicon-Via Electromigration for 3-D Integrated Circuits Taking Advantage of Self-Healing Effect

Three-dimensional integration is considered to be a promising technology to tackle the global interconnect scaling problem for terascale integrated circuits (ICs). Three-dimensional ICs typically employ through-silicon-vias (TSVs) to vertically connect planar circuits. Due to its immature fabrication process, several defects, such as void, misalignment, and dust contamination, may be introduced. These defects can significantly increase current densities within TSVs and cause severe electromigration (EM) effects, which can degrade the reliability of 3-D ICs considerably. In this paper, we propose an effective framework to mitigate EM effect of the defective TSV. At first, we analyze various possible TSV defects and their impacts on EM reliability. Based on the observation that EM can be significantly alleviated by self-healing effect, we design an EM mitigation module to protect defective TSVs from EM. To guarantee EM mitigation efficiency, we propose two defective TSV protection schemes, i.e., neighbor sharing and global sharing. Experimental results show that the global-sharing scheme performs the best and can improve the EM mean time to failure by more than 70× on average with only 0.7% area overhead and less than 0.5% performance degradation compared with naked design without any EM protection.
Evaluation of pre-implantation kidney biopsies: comparison of Banff criteria to a morphometric approach.

BACKGROUND Donor glomerulosclerosis, interstitial fibrosis, and fibrous intimal thickening correlate with graft outcome. We evaluate chronic lesions in donor biopsies according to Banff criteria and with a morphometric technique to ascertain their predictive value on graft outcome. METHODS We evaluated 77 cadaveric donor biopsies according to Banff criteria. Glomerulosclerosis was expressed as the percentage of global sclerotic glomeruli. The following morphometric parameters were obtained: cortical interstitial volume fraction (Vvint/c), cortical glomerular volume fraction (Vvglom/c), mean glomerular volume (Vg), mean and maximal intimal arterial volume fraction (Vvintima/art), and Vvintima/art of the largest artery. We evaluated the correlation of histologic lesions with delayed graft function, 3 months' glomerular filtration rate (GFR), and death-censored graft survival. RESULTS Multivariate logistic regression showed that delayed graft function was associated with cv score [relative risk (RR) 4.2 and 95% CI 1.1 to 16.0) and glomerulosclerosis (RR 1.06 and 95% CI 1.01 to 1.13). Stepwise regression showed that Vvint/c and glomerulosclerosis were independent predictors of 3 months' GFR (R= 0.62, P= 0.0001). Repeated analysis not considering morphometric parameters showed that glomerulosclerosis, cv score and ci score were independent predictors of 3 months' GFR (R= 0.64, P= 0.0001). A donor chronic damage score was generated considering glomerulosclerosis, cv score and ci score. This score after adjusting for clinical variables was associated with 3 months' GFR (R= 0.71, P < 0.0001) and death-censored graft survival (RR 2.2 and 95% CI 1.3 to 3.7). CONCLUSION Combined evaluation of donor glomerulosclerosis, chronic vascular and interstitial damage according to Banff criteria allows a precise prediction of graft outcome. Morphometric evaluation of donor biopsies does not improve the predictive value of semiquantitative grading.
Implications and Outcome of Permanent Coronary Sinus Lead Extraction and Reimplantation

Objective: We examined the implications and outcome of coronary sinus (CS) lead removal including the feasibility of laser use within the CS. Background: Cardiac anatomy and lead interactions are more complex with the advent of biventricular pacemakers and atrial cardioverters requiring permanent lead/shocking coil placement in the coronary sinus and its branches. Methods: Fifty‐five permanent cardiac leads were extracted during 2003 in 28 consecutive patients. Our study population included a 10/55 (18%) subset (all males; age 73 ± 6 years; EF = 0.24 ± 0.09) that underwent CS (1/10) or vein branch (9/10) lead extraction. Leads were extracted with an excimer laser sheath (n = 4) or by direct traction (n = 6). Median times between implantation and lead removal were 9.5 months (range 5–59) in the laser group and 3 months (range 3–4) in the direct traction group. Indication for extraction was infection (n = 4), dislodgement (n = 3), diaphragm stimulation (n = 2), and elevated threshold (n = 1). The CS was divided into distal, mid, and proximal segments by venogram. Results: Entry of the laser sheath into the CS was necessary in three of four laser patients. The two distal CS laser cases (left lateral CS coil and anterior‐lateral left ventricular (LV) lead) required both 14‐ and 12‐Fr sheaths, separately. The proximal CS laser case (posterior‐lateral LV lead) required a 12 Fr sheath. The remaining laser patient required a 12‐Fr sheath to pass to the mid SVC. There were no procedural complications as a result of CS lead extraction. Reimplantation of a CS lead was attempted in 7/10 patients at a median of 4 days (range 1–300). CS venograms were available for review in patients before initial implantation (6/10) and after extraction (7/10). The postextraction venograms demonstrated complete occlusion of the vein from which the lead was extracted, and its distal branches, which were unusable in 5/10 (50%). The vein occlusions were present in patients with indwelling leads for greater than 3 months and were independent of extraction method. Conclusions: Laser lead extraction in the coronary sinus appears feasible in carefully selected cases with mandatory indications. However, special intraoperative monitoring and echocardiographic imaging with surgical backup ready is strongly recommended. Target vein selection may be limited for the purpose of reimplantation when leads are indwelling for greater than 3 months.