Miracle-dz/UniFAR-FTUs huggingface dataset:
Automatic Topic Ontology Construction Using Semantic Relations from WordNet and Wikipedia

Due to the explosive growth of web technology, a huge amount of information is available as web resources over the Internet. Therefore, in order to access the relevant content from the web resources effectively, considerable attention is paid on the semantic web for efficient knowledge sharing and interoperability. Topic ontology is a hierarchy of a set of topics that are interconnected using semantic relations, which is being increasingly used in the web mining techniques. Reviews of the past research reveal that semiautomatic ontology is not capable of handling high usage. This shortcoming prompted the authors to develop an automatic topic ontology construction process. However, in the past many attempts have been made by other researchers to utilize the automatic construction of ontology, which turned out to be challenging due to time, cost and maintenance. In this paper, the authors have proposed a corpus based novel approach to enrich the set of categories in the ODP by automatically identifying the concepts and their associated semantic relationship with corpus based external knowledge resources, such as Wikipedia and WordNet. This topic ontology construction approach relies on concept acquisition and semantic relation extraction. A Jena API framework has been developed to organize the set of extracted semantic concepts, while Protege provides the platform to visualize the automatically constructed topic ontology. To evaluate the performance, web documents were classified using SVM classifier based on ODP and topic ontology. The topic ontology based classification produced better accuracy than ODP.
Complete Chemical Synthesis, Assembly, and Cloning of a Mycoplasma genitalium Genome

We have synthesized a 582,970–base pair Mycoplasma genitalium genome. This synthetic genome, named M. genitalium JCVI-1.0, contains all the genes of wild-type M. genitalium G37 except MG408, which was disrupted by an antibiotic marker to block pathogenicity and to allow for selection. To identify the genome as synthetic, we inserted “watermarks” at intergenic sites known to tolerate transposon insertions. Overlapping “cassettes” of 5 to 7 kilobases (kb), assembled from chemically synthesized oligonucleotides, were joined by in vitro recombination to produce intermediate assemblies of approximately 24 kb, 72 kb (“1/8 genome”), and 144 kb (“1/4 genome”), which were all cloned as bacterial artificial chromosomes in Escherichia coli. Most of these intermediate clones were sequenced, and clones of all four 1/4 genomes with the correct sequence were identified. The complete synthetic genome was assembled by transformation-associated recombination cloning in the yeast Saccharomyces cerevisiae, then isolated and sequenced. A clone with the correct sequence was identified. The methods described here will be generally useful for constructing large DNA molecules from chemically synthesized pieces and also from combinations of natural and synthetic DNA segments.
Transformative Learning of Pre-Service Teachers during Study Abroad in Reggio Emilia, Italy: A Case Study.

Only a small percentage of pre-service teachers are exposed to meaningful, comprehensive curricula that enhance global competence (Lucas & Villegas, 2002; Tucker, 1982; Wells, 2008). In response to pre-service teachers’ limited exposure to diverse curricula, many universities offer international study abroad programs that provide students with experiences designed to increase multicultural and global awareness that they may not receive in their regular coursework. This paper shares how a Study Abroad Program to Reggio Emilia, Italy transformed pre-service teachers’ learning experiences. Conclusions, discussions, and recommendations for future research are also included.
Cyber Junkie: Escape the Gaming and Internet Trap

Recovering video game addict Kevin Roberts offers a step-by-step guide to recovery for those struggling with compulsive video gaming and internet surfing.Video gaming and Internet surfing are the top sources of entertainment for tens of millions of North Americans today. As these technologies continue to grow and flourish, so does the number of people becoming obsessively absorbed in the imagination and fantasy that they present. More and more people are isolating themselves, turning their backs on reality, ignoring family and friends, and losing their sleep and even their jobs due to excessive use of video games and the Internet--and they continue to do so despite harmful consequences to their mental, physical, and spiritual health, a telltale sign of addiction.In this groundbreaking book, recovering video game addict Kevin Roberts uses extensive scientific and social research, complemented by his and others' personal stories, to give compulsive gamers and surfers--and their family and friends--a step-by-step guide for recovery. He outlines the ways that "cyber junkies" exhibit the classic signs of addiction and reveals how they can successfully recover by following a program similar to those used for other addictions. Readers learn to identify whether they have an addiction, find the right resources to get individualized help, and regain a rewarding life away from the screen by learning new thoughts and behaviors that free them from the cravings that rule their lives. Included is a guide for parents for working with their addicted children.
A Parallel Algorithm Based on Prefix Tree for Sequence Pattern Mining

Algorithm PTPSPM (a parallel algorithm based on prefix tree for sequence pattern mining) is proposed in order to deal with the speed limited and effectiveness problem of the sequence pattern mining in massive data. In this paper, a new prefix-tree structure and an improved prefix-span algorithm are introduced to mine the local sequence, the global sequence are obtained by merging all the local sequences. A new prefix tree pruning technique is presented to delete the global k-sequence which can not be attended. PTPSPM algorithm applies project database identifier index table of dynamic scheduling to avoid the processor idle waiting. Additionally, it cites selective sampling techniques to balance the loads between processors. The experiment results demonstrate that PTPSPM algorithm has better execution performance and speedup.
Steatosis affects chronic hepatitis C progression in a genotype specific way

Background and aims: Liver steatosis is frequent in chronic hepatitis C, particularly in patients infected with hepatitis C virus (HCV) genotype 3. The aim of this study was to determine the relationship between steatosis and fibrosis in chronic hepatitis C as a function of viral genotype. Methods: A multivariable logistic regression analysis was carried out in 755 chronic hepatitis C patients (mean body mass index (BMI) 24.11 kg/m2; 178 with genotype 3), consecutively admitted to three referral hospitals. Liver histology showed steatosis in 315 and fibrosis in 605 patients, of whom 187 had cirrhosis (78 compensated and 109 decompensated). Results: Steatosis was independently associated with fibrosis (p<0.001), genotype 3 (p<0.001), BMI (p<0.001), ongoing alcohol abuse (p<0.001), and age (p = 0.001). Fibrosis was associated with the Metavir activity score (p<0.001), age (p<0.001), steatosis (p = 0.001), past alcohol abuse for >5 years (p = 0.015), and BMI (p = 0.034). When regression analysis was repeated on patients divided according to viral genotype (that is, 3 v non-3) to identify type specific risk factors, steatosis was associated with ongoing alcohol abuse (p<0.001) and age (p = 0.01) only in non-3 genotype infected patients and with Metavir activity (p = 0.044) only in genotype 3 infected patients. Similarly, fibrosis was associated with steatosis only in genotype 3 infected individuals (p = 0.018), and with past alcohol abuse (p = 0.003) and (marginally) diabetes (p = 0.078) only in non-3 genotype infected patients. Conclusions: Steatosis influences chronic hepatitis C progression in a genotype specific way. Patients infected with genotype 3 and histologically confirmed steatosis should not be deferred from effective antiviral therapy.
Chatting Activity Recognition in Social Occasions Using Factorial Conditional Random Fields with Iterative Classification

Recognizing activities in social occasions plays an important role of building human social networks. For example, the recognition of social interactions could be of great help to determine whether any two attendees have the same interests in an academic conference or a cocktail party. Among the various types of social interactions, chatting with others is a significant indicator. Furthermore, the duration of a chatting activity may imply the strength of the interaction in reality. It is therefore important to recognize the patterns of chatting activities in social occasions. During a real-world conversation, a person often begins talking following the other person’s utterance is completed. Linguistic experts have observed that chatting interaction is usually performed as an interlaced dialogic process. As a result, it is intuitive to apply dynamic probabilistic models to learning and detecting chatting activities.
Volume 2 Scaffolding in Open-Ended Learning Environments ( OELEs )

Digital games have the potential to make unique and powerful contributions to science education efforts. Much of that potential, however, remains unrealized, partly because powerful games for science learning need to synergistically augment commercial game design conventions and principles with design principles specific to the goals and nature of science learning and research on science learning. This paper builds on earlier frameworks outlining the affordances of commercial game design conventions for learning by proposing three design principles to help students explicitly articulate the intuitive science learning inherent in good game play in terms of formal science concepts and representations. We discuss these principles in the context of our recent and ongoing work in the SURGE projects. These projects investigate effective game mechanics to help students organize their tacit understandings about Newtonian mechanics into more formalized concepts.
Reproducibility of performance changes to simulated live high/train low altitude.

UNLABELLED Elite athletes often undertake multiple altitude exposures within and between training years in an attempt to improve sea level performance. PURPOSE To quantify the reproducibility of responses to live high/train low (LHTL) altitude exposure in the same group of athletes. METHODS Sixteen highly trained runners with maximal aerobic power (VO2max) of 73.1 +/- 4.6 and 64.4 +/- 3.2 mL x kg(-1) x min(-1) (mean +/- SD) for males and females, respectively, completed 2 x 3-wk blocks of simulated LHTL (14 h x d(-1), 3000 m) or resided near sea level (600 m) in a controlled study design. Changes in the 4.5-km time trial performance and physiological measures including VO2max, running economy and hemoglobin mass (Hb(mass)) were assessed. RESULTS Time trial performance showed small and variable changes after each 3-wk altitude block in both the LHTL (mean [+/-90% confidence limits]: -1.4% [+/-1.1%] and 0.7% [+/-1.3%]) and the control (0.5% [+/-1.5%] and -0.7% [+/-0.8%]) groups. The LHTL group demonstrated reproducible improvements in VO2max (2.1% [+/-2.1%] and 2.1% [+/-3.9%]) and Hb(mass) (2.8% [+/-2.1%] and 2.7% [+/-1.8%]) after each 3-wk block. Compared with those in the control group, the runners in the LHTL group were substantially faster after the first 3-wk block (LHTL - control = -1.9% [+/-1.8%]) and had substantially higher Hb(mass) after the second 3-wk block (4.2% [+/-2.1%]). There was no substantial difference in the change in mean VO2max between the groups after the first (1.2% [+/-3.3%]) or second 3-wk block (1.4% [+/-4.6%]). CONCLUSIONS Three-week LHTL altitude exposure can induce reproducible mean improvements in VO2max and Hb(mass) in highly trained runners, but changes in time trial performance seem to be more variable. Competitive performance is dependent not only on improvements in physiological capacities that underpin performance but also on a complex interaction of many factors including fitness, fatigue, and motivation.
The accounting of the simultaneous exposure of the low temperatures and the penetrating radiation at the circuit simulation of the BiJFET analog interfaces of the sensors

The article considers a choice of CAD system and SPICE-models for the circuit simulation of characteristics of the bipolar (BiJFET) analog integrated circuits (IC) at the exposure of the penetrating radiation (PR) and the low temperatures. The authors suggest a modified SPICE-model, which describes the nonmonotonic change of the peak drain current and the slope of the p-n junction FET (JFET) within the temperature range from −200°C to 30°C.
Dissociative Tendencies and Memory Performance on Directed-Forgetting Tasks

The current article presents two studies that aimed to replicate DePrince and Freyd's (2001, 2004) studies demonstrating that high and low dissociators differentially recall neutral and trauma words under conditions of varying cognitive load. We did not find this effect. This lack of replication was apparent for both free recall and word recognition memory and in both studies. In effect, we found little evidence to support betrayal trauma theory, yet observed increased memory fallibility, as demonstrated by lower general recall and (in one study) commission errors, in high dissociators.
Intratracheal pulmonary ventilation at low airway pressures in a ventilator-induced model of acute respiratory failure improves lung function and survival.

STUDY OBJECTIVE The pulmonary parenchyma in patients with acute respiratory failure (ARF) is commonly not involved in a homogenous disease process. Conventional mechanical ventilation (MV) at elevated positive end-expiratory pressure (PEEP) and peak inspiratory pressure (PIP) aims at recruiting collapsed or nonventilated lung units. Invariably, those pressures are also transmitted to the healthiest regions, with possible extension of the disease process (barotrauma). During intratracheal pulmonary ventilation (ITPV), a continuous flow of fresh gas is delivered directly at the carina, bypassing the dead space proximal to the catheter tip. In healthy sheep, it allows lowering tidal volume (VT) to as low as 1.0 mL/kg, at respiratory rates (RR) up to 120 breaths/min, while maintaining normocapnia. In a model of ventilator-induced lung injury, we wished to explore whether ITPV, applied at low VT and low PEEP and tailored to ventilate the healthiest regions of the lungs, could provide adequate oxygenation and alveolar ventilation, without any attempt to recruit lungs. DESIGN Randomized study in sheep. SETTING Animal research laboratory. PARTICIPANTS We induced ARF in 12 sheep following 1 to 2 days of MV at a PIP of 50 cm H2O, except that 5 to 8% of lungs were kept on apneic oxygenation of 5 cm H2O, sparing those regions from the injury process. INTERVENTIONS Sheep were randomized to volume-controlled MV (control group) (n = 6) with VT of 8 to 12 mL/kg, PEEP of 5 to 10 cm H2O, or to ITPV (n = 6) at PEEP of 3 to 5 cm H2O, VT of 2.5 to 4 mL/kg, PIP of <20 cm H2O, at RRs sufficient to sustain normocapnia. MEASUREMENTS AND RESULTS Hemodynamic status in the ITPV group progressively improved, and all six sheep were weaned to room air within 83+/-54 h. Sheep in the control group had progressively deteriorating conditions and all animals died after a mean of 50+/-39 h. Barotrauma and postmortem histopathologic changes were more pronounced in the control group. CONCLUSION In this model of ventilator-induced lung injury, low PEEP-low VT ventilation with ITPV sustained normocapnia and prevented further lung injury, allowing weaning to room air ventilation.
Design of variable speed scheme for five level DC link inverter for synchronous motor using boost converter

Speed control design of the Permanent magnet brushless dc motor (PMBLDC) using MLDC inverter given a Boost Converter is explained in this paper. The MLDC inverter is having five constant voltage sources, which are controlled by two switches each for a constant voltage source. The variable speed of the synchronous motor can be obtained by controlling these voltage sources The speed cannot be controlled in traditional inverter. It consists of only one voltage source. The fundamental value of the output voltage can be achieved by increasing the number of constant dc voltage cells. To obtain rated voltage across motor the boost converter is situated. This increases the dc voltage up to the required value. The results of traditional inverter and five level inverter is compared and expressed with matlab simulations.
CRL2LRR-1 E3-Ligase Regulates Proliferation and Progression through Meiosis in the Caenorhabditis elegans Germline

The ubiquitin-proteolytic system controls the stability of proteins in space and time. In this study, using a temperature-sensitive mutant allele of the cul-2 gene, we show that CRL2LRR-1 (CUL-2 RING E3 ubiquitin-ligase and the Leucine Rich Repeat 1 substrate recognition subunit) acts at multiple levels to control germline development. CRL2LRR-1 promotes germ cell proliferation by counteracting the DNA replication ATL-1 checkpoint pathway. CRL2LRR-1 also participates in the mitotic proliferation/meiotic entry decision, presumably controlling the stability of meiotic promoting factors in the mitotic zone of the germline. Finally, CRL2LRR-1 inhibits the first steps of meiotic prophase by targeting in mitotic germ cells degradation of the HORMA domain-containing protein HTP-3, required for loading synaptonemal complex components onto meiotic chromosomes. Given its widespread evolutionary conservation, CUL-2 may similarly regulate germline development in other organisms as well.
Uncoordinated 119 Preferentially Induces Th2 Differentiation and Promotes the Development of Asthma

The Th2 bias is a hallmark of allergic diseases. In this study, we show that the Th1 versus Th2 balance and the development of allergic asthma are strongly affected by the signaling protein uncoordinated 119 (Unc119). The expression of this adaptor protein is significantly increased in Th2 cells. Unc119 activates the Src family and inhibits the Abl family of tyrosine kinases. The activated Src family kinase Lck stimulates the activity of Itk and the expression of the transcription factor JunB. As a result, Unc119 promotes IL-4 production. Through inhibition of Abl kinases, Unc119 dampens IFN-γ production. Using adoptive transfer of Unc119-knockdown CD4 T cells, we show a critical role for Unc119 in the development of eosinophilic inflammation of airways, mucus production, and bronchial hyperreactivity in a mouse model. Intriguingly, the expression of the Unc119 protein is enhanced in CD4 T cells from patients with asthma. We speculate that the heightened expression of Unc119 promotes Th2, inhibits Th1 differentiation, and contributes to the pathogenesis of asthma in humans.
Persistence and Permanence of Mass-Action and Power-Law Dynamical Systems

Persistence and permanence are properties of dynamical systems that describe the long-term behavior of the solutions and in particular specify whether positive solutions approach the boundary of the positive orthant. Mass-action systems (or more generally power-law systems) are very common in chemistry, biology, and engineering and are often used to describe the dynamics in interaction networks. We prove that two-species mass-action systems derived from weakly reversible networks are both persistent and permanent, for any values of the reaction rate parameters. Moreover, we prove that a larger class of networks, called endotactic networks, also give rise to permanent systems, even if the reaction rate parameters vary in time (to allow for the influence of external signals). These results also apply to power-law systems and other nonlinear dynamical systems. In addition, ideas behind these results allow us to prove the global attractor conjecture for three-species systems.
Effect of salmeterol on respiratory muscle activity during exercise in poorly reversible COPD

Background: Some patients with irreversible chronic obstructive pulmonary disease (COPD) experience subjective benefit from long acting bronchodilators without change in forced expiratory volume in 1 second (FEV1). Dynamic hyperinflation is an important determinant of exercise induced dyspnoea in COPD. We hypothesised that long acting bronchodilators improve symptoms by reducing dynamic hyperinflation and work of breathing, as measured by respiratory muscle pressure-time products. Methods: Sixteen patients with “irreversible” COPD (<10% improvement in FEV1 following a bronchodilator challenge; mean FEV1 31.1% predicted) were recruited into a randomised, double blind, placebo controlled, crossover study of salmeterol (50 μg twice a day). Treatment periods were of 2 weeks duration with a 2 week washout period. Primary outcome measures were end exercise isotime transdiaphragmatic pressure-time product and dynamic hyperinflation as measured by inspiratory capacity. Results: Salmeterol significantly reduced the transdiaphragmatic pressure-time product (294.5 v 348.6 cm H2O/s/min; p = 0.03), dynamic hyperinflation (0.22 v 0.33 litres; p = 0.002), and Borg scores during endurance treadmill walk (3.78 v 4.62; p = 0.02). There was no significant change in exercise endurance time. Improvements in isotime Borg score were significantly correlated to changes in tidal volume/oesophageal pressure swings, end expiratory lung volume, and inspiratory capacity, but not pressure-time products. Conclusions: Despite apparent “non-reversibility” in spirometric parameters, long acting bronchodilators can cause both symptomatic and physiological improvement during exercise in severe COPD.
Efficience vs inefficience des organisations publiques : la contribution des théories contractuelles

Depuis la remise en question de l’efficacite des entreprises publiques dans les annees 1960, les privatisations dans le monde ont fortement progresse. Est-ce donc le signe d’une disparition programmee de l’organisation publique ? Nous proposons sur la base de travaux empiriques et theoriques, une analyse comparative des formes organisationnelles publiques et privees a partir des apports offerts par les theories contractuelles. Dans ce contexte theorique, nous montrons que l’organisation publique peut etre efficiente. Nous concluons finalement sur la necessite de developper un cadre theorique des organisations apte a integrer l’ensemble des variables associees a la propriete, quelle soit publique ou privee.
Qualitative representation of building sites annoyance

Urban building sites are often a source of various kinds of annoyances. In FURET1 project, we aim at developing a planning approach and a spatial decision support system (SDSS) dedicated to reducing the annoyance generated by urban building sites, particularly in dense urban environments. In this paper, we focus our work on the modelling of the annoyances generated by the urban building sites. Specifically, we present a new method based on linguistic approach that allows qualitative evaluation of annoyances. This method will be implemented in a SDSS to help managers of public spaces to reduce annoyances and improve the quality of life of the citizens.