Miracle-dz/UniFAR-FTUs huggingface dataset:
High‐resolution MRS in the presence of field inhomogeneity via intermolecular double‐quantum coherences on a 3‐T whole‐body scanner

Signals from intermolecular double‐quantum coherences (iDQCs) have been shown to be insensitive to macroscopic field inhomogeneities and thus enable acquisition of high‐ resolution MR spectroscopy in the presence of large inhomogeneous fields. In this paper, localized iDQC 1H spectroscopy on a whole‐body 3‐T MR scanner is reported. Experiments with a brain metabolite phantom were performed to quantify characteristics of the iDQC signal under different conditions. The feasibility of in vivo iDQC high‐resolution MR spectroscopy in the presence of large intrinsic and external field inhomogeneity (in the order of hundreds of hertz) was demonstrated in the whole cerebellum of normal volunteers in a scan time of about 6.5 min. Major metabolite peaks were well resolved in the reconstructed one‐dimensional spectra projected from two‐dimensional iDQC acquisitions. Investigations on metabolite ratios, signal‐to‐noise ratio, and line width were performed and compared with results obtained with conventional point‐resolved spectroscopy/MR spectroscopy in homogeneous fields. Metabolite ratios from iDQC results showed excellent consistency under different in vitro and in vivo conditions, and they were similar to those from point‐resolved spectroscopy with small voxel sizes in homogeneous fields. MR spectroscopy with iDQCs can be applied potentially for quantification of gross metabolite changes due to diseases in large brain volumes with high field inhomogeneity. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.
Heuristic-Based Shiftable Loads Optimal Management in Smart Micro-Grids

In this paper, an optimal power dispatch problem on a 24-h basis for distribution systems with distributed energy resources (DER) also including directly controlled shiftable loads is presented. In the literature, the optimal energy management problems in smart grids (SGs) where such types of loads exist are formulated using integer or mixed integer variables. In this paper, a new formulation of shiftable loads is employed. Such formulation allows reduction in the number of optimization variables and the adoption of real valued optimization methods such as the one proposed in this paper. The method applied is a novel nature-inspired multiobjective optimization algorithm based on an original extension of a glowworm swarm particles optimization algorithm, with algorithmic enhancements to treat multiple objective formulations. The performance of the algorithm is compared to the NSGA-II on the considered power systems application.
Designing mixed-method research inspired by a critical realism philosophy: A tale from the field of IS innovation

Despite the call for pluralism in IS research there is a lack of multi-method research published in information systems journals. While many researchers might find the idea of using multiple methods attractive, there are barriers that prevent them from employing this approach in practice. In this paper we try to address key philosophical concerns that often deter more extensive use of multiple methods, encourage openness to innovative methodological choices, and deepen practical understanding about how critical realism can be used as the foundation of IS research designs. We begin by exploring the value of critical realism as a theoretical foundation for mixed-method information systems research. After discussing the debate surrounding quantitative methods (especially within economics) among critical realists, we propose making the identification of demi-regularities pivotal to the design of qualitative fieldwork. To provide support for this approach we present evidence from a study on the economic impact of IS innovation adoption in financial services which we believe highlights the value of multiple methods to inspire and inform the research process as it unfolds.
Survey of Low rate Denial of Service (LDoS) attack on RED and its counter strategies

RED Active Queue Management is designed to avoid congestion by controlling the average queue size. Also it avoids TCP global synchronization and provides a bias against burst traffic. But studies show that RED is vulnerable to Shrew attacks. Shrew attack is a Low rate Denial of Service (LDoS) attack, if properly executed could exploit TCP's re-transmission time-out mechanism (RTO) and ultimately reduce its throughput to zero. LDoS attack is very difficult to identify because the average rate of packet sending will be very low. This is achieved by sending large amount of packets for a very short duration and repeating this process in regular intervals. This article analyzes the effect of LDoS attack on TCP as well as RED and compares the existing prevention methods. It also proposes an RED based method to detect and prevent LDoS attacks.
High-density linkage mapping and distribution of segregation distortion regions in the oak genome

We developed the densest single-nucleotide polymorphism (SNP)-based linkage genetic map to date for the genus Quercus. An 8k gene-based SNP array was used to genotype more than 1,000 full-sibs from two intraspecific and two interspecific full-sib families of Quercus petraea and Quercus robur. A high degree of collinearity was observed between the eight parental maps of the two species. A composite map was then established with 4,261 SNP markers spanning 742 cM over the 12 linkage groups (LGs) of the oak genome. Nine genomic regions from six LGs displayed highly significant distortions of segregation. Two main hypotheses concerning the mechanisms underlying segregation distortion are discussed: genetic load vs. reproductive barriers. Our findings suggest a predominance of pre-zygotic to post-zygotic barriers.
Manipulating the NF-κB pathway in macrophages using mannosylated, siRNA-delivering nanoparticles can induce immunostimulatory and tumor cytotoxic functions

Tumor-associated macrophages (TAMs) are critically important in the context of solid tumor progression. Counterintuitively, these host immune cells can often support tumor cells along the path from primary tumor to metastatic colonization and growth. Thus, the ability to transform protumor TAMs into antitumor, immune-reactive macrophages would have significant therapeutic potential. However, in order to achieve these effects, two major hurdles would need to be overcome: development of a methodology to specifically target macrophages and increased knowledge of the optimal targets for cell-signaling modulation. This study addresses both of these obstacles and furthers the development of a therapeutic agent based on this strategy. Using ex vivo macrophages in culture, the efficacy of mannosylated nanoparticles to deliver small interfering RNA specifically to TAMs and modify signaling pathways is characterized. Then, selective small interfering RNA delivery is tested for the ability to inhibit gene targets within the canonical or alternative nuclear factor-kappaB pathways and result in antitumor phenotypes. Results confirm that the mannosylated nanoparticle approach can be used to modulate signaling within macrophages. We also identify appropriate gene targets in critical regulatory pathways. These findings represent an important advance toward the development of a novel cancer therapy that would minimize side effects because of the targeted nature of the intervention and that has rapid translational potential.
Access Selection in Always Best Connected Networks

In the recent years, the wireless communication is developing in a very tremendous speed. Various kinds of radio access technologies have been used all over the world that brings us an opportunity of being always best connected. In this paper, we will focus on the access selection of the network and make an architecture to give users a simple, effective and convenient way to be best connected. In designing the optimizer of the architecture, we take QoS and prices of the services both into consideration to satisfy the needs of most ordinary users who are not proficient in the wireless access services. Throughout analysis, this architecture demonstrates that it will benefit users a lot in the near future.
Autonomous Matchmaking Web Services

Current Semantic Web Services research investigates how to dynamically discover assemble and invoke Web services. Despite many research efforts, Semantic Web Services are still not fully recognized in industry. One important reason is the dissevered description layers of syntax and semantics. In other words, semantics is only useful for a service broker to discover services whereas service requesters still need to invoke services based on syntactic descriptions. In this paper, we view semantics from another angle to reform the Web service framework completely (even for input messages and output messages during invocation) by using only RDF and Linked Open Data. We introduce Autonomous Matchmaking Web Services in which Web services are brokering themselves to notify the service registry whether they are suitable to the requesters. This framework is designated to more efficiently work for dynamically assembling services at run time in a massively distributed environment.
Do Premenopausal Women with Major Depression Have Low Bone Mineral Density? A 36-Month Prospective Study

Background An inverse relationship between major depressive disorder (MDD) and bone mineral density (BMD) has been suggested, but prospective evaluation in premenopausal women is lacking. Methods Participants of this prospective study were 21 to 45 year-old premenopausal women with MDD (n = 92) and healthy controls (n = 44). We measured BMD at the anteroposterior lumbar spine, femoral neck, total hip, mid-distal radius, trochanter, and Ward's triangle, as well as serum intact parathyroid hormone (iPTH), ionized calcium, plasma adrenocorticotropic hormone (ACTH), serum cortisol, and 24-hour urinary-free cortisol levels at 0, 6, 12, 24, and 36 months. 25-hydroxyvitamin D was measured at baseline. Results At baseline, BMD tended to be lower in women with MDD compared to controls and BMD remained stable over time in both groups. At baseline, 6, 12, and 24 months intact PTH levels were significantly higher in women with MDD vs. controls. At baseline, ionized calcium and 25-hydroxyvitamin D levels were significantly lower in women with MDD compared to controls. At baseline and 12 months, bone-specific alkaline phosphatase, a marker of bone formation, was significantly higher in women with MDD vs. controls. Plasma ACTH was also higher in women with MDD at baseline and 6 months. Serum osteocalcin, urinary N-telopeptide, serum cortisol, and urinary free cortisol levels were not different between the two groups throughout the study. Conclusion Women with MDD tended to have lower BMD than controls over time. Larger and longer studies are necessary to extend these observations with the possibility of prophylactic therapy for osteoporosis. Trial Registration ClinicalTrials.gov NCT 00006180
A Learning-Based Approach for the Identification of Sexual Predators in Chat Logs

The existence of sexual predators that enter into chat rooms or forums and try to convince children to provide some sexual favour is a socially worrying issue. Manually monitoring these interactions is a way to attack this problem. However, this manual approach simply cannot keep pace because of the high number of conversations and the huge number of chatrooms or forums where these conversations daily take place. We need tools that automatically process massive amounts of conversations and alert about possible offenses. The sexual predator identification challenge within PAN 2012 is a valuable way to promote research in this area. Our team faced this task as a Machine Learning problem and we designed several innovative sets of features that guide the construction of classifiers for identifying sexual predation. Our methods are driven by psycholinguistic, chat-based, and tf/idf features and yield to very effective classifiers.
ar X iv : h ept h / 04 08 12 1 v 1 1 6 A ug 2 00 4 YITP-0445 hep-th / 0408121 Heterotic on Half-flat

We study the effective action of the heterotic string compactified on particular half-flat manifolds which arise in the context of mirror symmetry with NS-NS flux. We explicitly derive the superpotential and Kähler potential at lowest order in α by a reduction of the bosonic action. The superpotential contains new terms depending on the Kähler moduli which originate from the intrinsic geometrical flux of the half-flat manifolds. A generalized Gukov formula, valid for all manifolds with SU(3) structure, is derived from the gravitino mass term. For the half-flat manifolds it leads to a superpotential in agreement with our explicit bosonic calculation. We also discuss the inclusion of gauge fields. August 2004 email: gurrieri@yukawa.kyoto-u.ac. jp email: A.Lukas@sussex.ac. uk email: A.Micu@sussex.ac. uk On leave from IFIN-HH Bucharest.
Online Real-Time Task Scheduling in Heterogeneous Multicore System-on-a-Chip

Online task scheduling in heterogeneous multicore system-on-a-chip is a challenging problem due to precedence constraints and nonpreemptive task execution in the synergistic processor core. This study first proposes an online heterogeneous dual-core scheduling framework for dynamic workloads with real-time constraints. The general purpose processor core and the synergistic processor core are dedicated to separate schedulers with different scheduling policies, and precedence constraints among tasks are dealt with through interaction between the two schedulers. This framework is also configurable for low priority inversion and high system utilization. We then extend this framework to heterogeneous multicore systems with well-known dispatcher schemas. This paper presents a real case study to show the practicability of the proposed methodology, and presents a series of extensive simulations to obtain comparison studies using different workloads and scheduling algorithms.
Kinetics of Murine Gammaherpesvirus 68 Gene Expression following Infection of Murine Cells in Culture and in Mice

ABSTRACT A model system to study the pathogenesis of gammaherpesvirus infections is the infection of mice with murine gammaherpesvirus 68 (MHV-68). To define the kinetics of infection, we developed an RNase protection assay to quantitate gene expression from lytic (K3, Rta, M8, DNA polymerase [DNA pol], and gB) and candidate latency (M2, M3, M9, M11, ORF73, and ORF74) genes. All candidate latency genes were expressed during lytic infection of 3T3 cells. Four kinetic classes of transcripts were observed following infection of 3T3 cells: immediate-early (K3, Rta, M8, and ORF73), early (DNA pol), early-late (M3, M11, and ORF74), and late (M2, M9, and gB). To assess the kinetics of viral gene expression in vivo, lungs, spleens, and mediastinal lymph nodes (MLN) were harvested from MHV-68-infected mice. All transcripts were expressed between 3 and 6 days postinfection (dpi) in the lungs. In the spleen, K3, M3, M8, and M9 transcripts were expressed between 10 and 16 dpi when latency is established. The K3, M3, M8, M9, and M11 transcripts were detected in the MLN from 2 through 16 dpi. This is the first demonstration of MHV-68 gene expression in the MLN. Importantly, our data showed that MHV-68 has different kinetics of gene expression at different sites of infection. Furthermore, we demonstrated that K3, a gene recently shown to encode a protein that downregulates major histocompatibility complex class I on the surface of cells, is expressed during latency, which argues for a role of K3 in immune evasion during latent infection.
RFID authentication protocol for low-cost tags

In this paper, we investigate the possible privacy and security threats to RFID systems, and consider whether previously proposed RFID protocols address these threats. We then propose a new authentication protocol which provides the identified privacy and security features and is also efficient. The new protocol resists tag information leakage, tag location tracking, replay attacks, denial of service attacks, backward traceability, forward traceability (under an assumption), and server impersonation (also under an assumption). We also show that it requires less tag-side storage and computation than other similarly structured RFID protocols.
On the Formation of Compact Stellar Disks around Sagittarius A*

The recent identification of one or two subparsec disks of young, massive stars orbiting the ~4 × 106 M☉ black hole Sgr A* has prompted an in situ scenario for star formation in disks of gas formed from a cloud captured from the Galactic center environment. To date there has been no explanation given for the low angular momentum of the disks relative to clouds passing close to the center. Here we show that the partial accretion of extended Galactic center clouds, such as the 50 km s−1 giant molecular cloud, that temporarily engulf Sgr A* during their passage through the central region of the Galaxy provide a natural explanation for the angular momentum and surface density of the observed stellar disks. The captured cloud material is gravitationally unstable and forms stars as it circularizes, potentially explaining the large eccentricity and range of inclinations of the observed stellar orbits. The application of this idea to the formation of the circumnuclear ring is also discussed.
On-chip interconnects and instruction steering schemes for clustered microarchitectures

Clustering is an effective microarchitectural technique for reducing the impact of wire delays, the complexity, and the power requirements of microprocessors. In this work, we investigate the design of on-chip interconnection networks for clustered superscalar microarchitectures. This new class of interconnects has demands and characteristics different from traditional multiprocessor networks. In particular, in a clustered microarchitecture, a low intercluster communication latency is essential for high performance. We propose some point-to-point cluster interconnects and new improved instruction steering schemes. The results show that these point-to-point interconnects achieve much better performance than bus-based ones, and that the connectivity of the network together with effective steering schemes are key for high performance. We also show that these interconnects can be built with simple hardware and achieve a performance close to that of an idealized contention-free model.
Quantum gravity without Lorentz invariance

There has been a significant surge of interest in Hoyrava's model for 3+1 dimensional quantum gravity, this model being based on anisotropic scaling at a z = 3 Lifshitz point. Hoyrava's model, and its variants, show dramatically improved ultra- violet behaviour at the cost of exhibiting violation of Lorentz invariance at ultra- high momenta. Following up on our earlier note, Phys. Rev. Lett. 102 (2009) 251601 (arXiv:0904.4464 (hep-th)), we discuss in more detail our variant of Hoyrava's model. In contrast to Hoyrava's original model, we abandon "detailed balance" and restore parity invariance. We retain, however, Hoyrava's "projectability condition" and explore its implications. Under these conditions, we explicitly exhibit the most general model, and extract the full classical equations of motion in ADM form. We analyze both spin-2 and spin-0 graviton propagators around flat Minkowski space. We furthermore analyze the classical evolution of FLRW cosmologies in this model, demonstrating that the higher-derivative spatial curvature terms can be used to mimic radiation fluid and stiff matter. We conclude with some observations concerning future prospects. 17 May 2009; 20 May 2009; 29 June 2009; 2 Sept 2009; L A T E X-ed October 13, 2009.
Executive Control in Bilingual Language Processing

Little is known in cognitive neuroscience about the brain mechanisms and brain representations involved in bilingual language processing. On the basis of previous studies on switching and bilingualism, it has been proposed that executive functions are engaged in the control and regulation of the languages in use. Here, we review the existing evidence regarding the implication of executive functions in bilingual processing using event-related brain potentials and functional magnetic resonance imaging. Several brain potential experiments have shown an increased negativity at frontocentral areas in bilinguals, probably related to the activation of medial prefrontal regions, for different tasks, languages, and populations. Enhanced cognitive control is required in bilinguals, which also involves the recruitment of the left dorso-lateral prefrontal cortex. The degree of activation of this mechanism is also discussed considering the similarity of languages in use at the lexical, grammatical, and phonological levels. We propose that the prefrontal cortex probably mediates cognitive control in bilingual speakers through the interplay between a top-down selection-suppression mechanism and a local inhibitory mechanism in charge of changing the degree of selection-suppression of the different lexicons.
Rituximab reduces the number of peripheral blood B-cells in vitro mainly by effector cell-mediated mechanisms.

BACKGROUND AND OBJECTIVES The humanized CD20 mono- clonal antibody, rituximab, has significant anti-tumor activity in patients with B-cell non-Hodgkin's lymphoma and induces depletion of B-cells in vivo. It was the objective of this study to define the contribution of the different mechanisms of action of rituximab on primary normal and malignant B-cells. DESIGN AND METHODS Primary human B-lymphocytes and effector cell fractions were isolated from peripheral blood of normal donors using an immunomagnetic separation technique. Blood samples from 20 patients with chronic lymphocytic leukemia (CLL) were studied and the B-lymphoblastoid Daudi cell line was used as a control. B-cells were cultured in the presence or absence of rituximab adding a secondary hyper-crosslinking antibody, serum as source of complement or different effector cell fractions. The cells were analyzed by immunofluorescence staining and flow cytometry. RESULTS In contrast to the B-lymphoblastoid Daudi cell line, the number of highly purified normal peripheral blood CD19+ cells was only minimally affected by rituximab in the presence of autologous serum. A significant reduction in the number of B-cells was observed when mononuclear cells from peripheral blood were added back. To identify the cell type which mediates this effect, CD3+ T-cells, CD56+ cells, and CD14+ monocytes were added to selected CD22+ B-cells. A marked B-cell decrease was only observed in the presence of CD56+ and CD14+ cells in an effector to target ratio of 10:1. The experiments with mononuclear cells from patients with CLL showed a B-cell reduction by rituximab, which was significantly enhanced following addition of granulocyte-macrophage colony-stimulating factor (GM-CSF). INTERPRETATION AND CONCLUSIONS These data support the important role of cell-mediated mechanisms in the B-cell-depleting action of rituximab and suggest that pre-treatment with GM-CSF could improve the response to rituximab in patients with CLL.
Model Comparison for  $1/f$ Noise in Oscillators With and Without AM to PM Noise Conversion

A new generalized 1/f Kurokawa noise analysis applicable to both low- and high-Q oscillators is proposed for 1/f phase modulation (PM) and amplitude modulation (AM) noise. A theoretical correspondence between the new generalized Kurokawa theory and the impulse sensitivity function and the perturbation projection vector (PPV) is also derived in the absence and presence of AM to PM noise conversion. The importance of AM to PM noise conversion effect is investigated next using a modified Van der Pol oscillator with fourth-order nonlinear capacitances and a harmonic short. The same analytic solution for the phase noise is derived for both the new generalized 1/f Kurokawa and the PPV analysis and is found to match the results from the conversion matrix method in two commercial harmonic-balance circuit simulators.