Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical predictors of a positive response to guided diagnostic block into the subacromial bursa.

OBJECTIVE To compare the accuracy of combinations of clinical examination findings for predicting a positive response to injection of local anaesthetic into the subacromial bursa. DESIGN Prospective, cohort, diagnostic validity design. SUBJECTS Consecutive patients with shoulder pain recruited from primary care physiotherapy and general medical practices. METHODS All subjects underwent a standardised clinical examination (index test) followed by a diagnostic injection of xylocaineTM into the subacromial bursa (reference standard test) performed under ultrasound guidance. Clinical examination variables associated with a positive anaesthetic response (≥ 80% post-injection reduction in pain intensity) were identified (p < 0.20) and diagnostic accuracy was calculated. RESULTS Of the 196 subjects who received a subacromial bursa injection, 66 subjects (34%) reported a positive anaesthetic response. Strain injury (adjusted odds ratio (AOR) 2.3), anterior shoulder pain (AOR 2.3) and absence of pain with external rotation at 90º abduction (AOR 3.9) were the strongest clinical predictors of positive anaesthetic response. Clinical prediction model variables demonstrated 100% specificity (3 positive tests) but low sensitivity (maximum 40%) for a positive anaesthetic response. Combinations of 9 other clinical variables also demonstrated 100% specificity (7 or more positive tests), and improved sensitivity (95 to 100%) for a PAR compared with clinical prediction model variables when less than two findings were present. CONCLUSION Combinations of these clinical tests may assist the clinician to differentiate subacromial pain from other shoulder conditions and guide selection of targeted pain management interventions. Additional diagnostic tests may be required when clinical criteria are not satisfied.
Reliability and validity of the Women's Health Initiative Insomnia Rating Scale.

The reliability and construct validity of the 5-item Women's Health Initiative Insomnia Rating Scale (WHIIRS) were evaluated in 2 studies. In Study 1, using a sample of 66,269 postmenopausal women, validity of the WHIIRS was assessed by examining its relationship to other measures known to be related to sleep quality. Reliability of the WHIIRS was estimated using a resampling approach; the mean alpha coefficient was . 78. Test-retest reliability coefficients were . 96 for same-day administration and . 66 after a year or more. Correlations of the WHIIRS with the other measures were in the predicted directions. Study 2 used a sample of 459 women and compared the WHIIRS with objective indicators of sleep quality. Results showed that differences in the objective indicators could be detected by the WHIIRS. Findings suggest that a between-group mean difference of approximately 0.50 of a standard deviation on the WHIIRS may be clinically meaningful.
An outbreak of toe ulcers, sole ulcers and white line disease in a group of dairy heifers immediately after calving

Abstract CASE HISTORY: An outbreak of severe lameness was reported on a 780-cow spring-calving dairy herd in the Manawatu region within 1–3 weeks of calving, which affected over 90% of a group of 150 dairy heifers. Approximately 3 weeks before the planned start of calving heifers had been fed maize and grass silage on a concrete feed pad for 3–4 h per day, and mixed with a group of adult cows. CLINICAL FINDINGS: During treatment for lameness, the feet of 28 lame heifers were closely examined. Seventy lesions were recorded in the claws of these heifers. The predominant lesion was severe solar and white line haemorrhage, with much of the haemorrhage focussed at the site at which sole ulcers are normally seen. White line disease was seen in nine claws and sole ulcers in four. Additionally, a lesion which is not commonly recorded in New Zealand, a toe abscess arising from separation of the white line from the sole in the abaxial region of tip of the toe was recorded in 11 claws. The clinical impression was that the soles of the affected heifers were very thin. This was supported by examination of the feet of eight heifers using ultrasonography that indicated heifers with hoof horn haemorrhages had very thin soles (estimated mean 4.1 mm) and that these soles were thinner than those in non-lame heifers without haemorrhages. DIAGNOSIS: The pattern of disease seen in these heifers closely matched that seen in an outbreak of lameness in heifers in Florida, which was linked to thin soles resulting from excess hoof horn wear. The clinical signs and findings of the examination using ultrasonography strongly implicated thin soles as the underlying cause of lameness on this farm. An on-farm investigation revealed a combination of heifer behaviour and prolonged exposure to wet concrete on the feed pad were the primary causes of excess wear that resulted in thin soles. CLINICAL RELEVANCE: This was an unusual outbreak of lameness in a group of newly calved heifers. The problem highlights the value of good management during the transition of heifers at pasture to the lactating herd standing on concrete for long periods, in the control of lameness.
Basics of Digital Microscopy

Digital microscopy combines the equipment of classic light microscopy with a computerized imaging system, i.e., a digital camera. This technique comprises image formation by optics, image registration by a camera, and saving of image data in a computer file. This chapter describes limitations that are particular to each of these processes, including optical resolution, efficiency of image registration, and characteristics of image file formats. Knowledge with regard to these limitations serves, in turn, to help construct a set of guidelines aimed at optimization of digital microscopic imaging.
PENGARUH LINGKUNGAN KERJA TERHADAP KEPUASAN KERJA KARYAWAN (Studi pada Karyawan PT.Telekomunikasi Indonesia Tbk. Kandatel Malang)

The aim of this study was investigate the effect of physical working environment and non-physical working environment on employee satisfaction, both simultaneously and partially. The research type is explanatory research. Questionnaire was used as tata collection method. The number of sample was 61 respondents of employees in PT. Telekomunikasi Indonesia Tbk, branch Kandatel Malang. Multiple regression analysis through software SPSS 16 was used to test the research hypothesis. The results showed that, the physical working environment and non-physical working environment simultaneously have significant effect on employee satisfaction, the physical working environment partially has a positive and significant effect on employee satisfaction, non-physical working environment partially has a positive and significant effect on employee satisfaction. Lastly, the R 2 in this study was 0.53, it’s means that the model can explained 53% to predict employee satisfaction, while 47% are explained by other variables that not included in this study. Keywords: Physical Working Environment, Non-Physical Working Environment, Employee Satisfaction ABSTRAK Tujuan penelitian ini adalah untuk menguji pengaruh lingkungan kerja fisik dan lingkungan kerja non-fisik terhadap kepuasan kerja karyawan, baik secara simultan maupun secara parsial. Jenis penelitian ini adalah penelitian eksplanatori. Kuosioner digunakan sebagai metode pengumpulan data. Jumlah sampel dalam penelitian yakni 61 responden karyawan di PT. Telekomunikasi Indonesia Tbk, cabang Kandatel Malang. Analisis regresi linier berganda dengan software SPSS 16 digunakan untuk menguji hipotesis penelitian. Hasil penelitian ini menunjukkan: lingkungan kerja fisik dan lingkungan kerja non-fisik secara simultan berpengaruh signifikan terhadap kepuasan kerja karyawan, lingkungan kerja fisik berpengaruh secara positif dan signifikan terhadap kepuasan kerja karyawan. Ketiga, lingkungan kerja non-fisik berpengaruh secara positif dan signifikan terhadap kepuasan kerja karyawan, R 2 pada penelitian ini adalah sebesar 53%, hal ini berarti bahwa model penelitian ini dapat menjelaskan 53% atas kepuasan kerja karyawan, sementara 47% dijelaskan oleh variabel lain yang tidak dimasukkan dalam penelitian ini. Kata Kunci: Lingkungan Kerja Fisik, Lingkungan Non-fisik, Kepuasan Kerja Karyawan
City schools : leading the way

Foreword - Marilyn Tallerico and Patrick B Forsyth Understanding the Urban Context and Conditions of Practice of School Administration - Richard M Englert Motivating Urban Learners - Patrick B Forsyth Managing Instructional Diversity - Linda F Winfield, Ruth Johnson and Joanne B Manning Building Open Climates in Urban Schools - James R Bliss Collecting and Using Information for Problem Solving and Decision Making - Robert O Slater Acquiring and Using Resources - Laurence J Parker Governing Urban Schools - Marilyn Tallerico Effecting Change in Urban Schools - William J Kritek Establishing the Mission, Vision, and Goals - Robert T Stout
Domain adaptation methods in the IBM trainable text-to-speech system

This paper presents a comparison of domain adaptation techniques for a unit selection based text-to-speech system. The methods under investigation consider two different prerequisites, namely the absence and the existence of additional domain specific training prompts, spoken by the original voice talent. Whereas in the first case we employ domain specific pre-selection, for the latter we compare a variety of methods that range from a simple extension of the segment inventory to a complete reconstruction of the system, which also includes the training of decision trees for the domain dependent prediction of prosody targets. An experimental evaluation of the methods under consideration unveils significant improvements (up to 1.1 on a 5 point MOS scale) over the baseline system for sentences from the target domain, while showing no significant degradation when synthesizing sentences from other than the adaptation domain.
A Model for Wind Turbines Placement Within a Distribution Network Acquisition Market

This paper proposes an innovative exhaustive search method for the optimal placement of wind turbines (WTs) in electrical distribution systems taking into account wind speed and load demand uncertainty, and the variability of electrical energy prices within a distribution network operator (DNO) acquisition market environment. The method combines Monte Carlo simulation (MCS) and market-based optimal power flow (OPF) to maximize the net present value (NPV) related to the investment made by WTs' developers over a planning horizon. In particular, the MCS data feed the market-based OPF problem with inter-temporal constraints in order to find the most convenient WTs allocation and priority on the network, based on distribution-locational marginal prices (D-LMPs) in a competitive electricity market. The effectiveness of the proposed method is demonstrated with an 84-bus 11.4-kV radial distribution system.
Infant attention, motor activity and cardiac activity and the effects of prenatal smoke exposure

To advance our understanding of the association between maternal smoking during pregnancy and the development of ADHD in offspring, studies using a prospective and longitudinal design, beginning with the study of temperament during infancy are required. The aim of this thesis was to investigate domains of infant temperament that could be considered early precursors and correlates of ADHD and to examine the effect of prenatal smoke exposure on these domains. Attention together with motor activity and heart rate (HR), measured during cognitive and emotional challenge, were studied in a representative, community sample of 130 infants at 6 and 12 months. At 6 months infants exposed to prenatal smoke showed more sustained attention, increased motor activity and increased HR compared with non-exposed infants. However, at 12 months there was no evidence of an effect of prenatal smoke exposure on attention or motor activity but there was evidence of an effect on HR. Given the importance of understanding temperament in infants, we examined 50 infants in an intensive laboratory assessment, using measures of vagal tone (VT) as well as HR, to enhance our understanding of the relationship between temperament and physiology. Results supported the use of HR as an index of temperament and although VT results were ambiguous, the indication was that measures of VT reactivity may be useful in future research. Combining the novel and rigorous designs presented in this thesis to study the effects of prenatal smoke exposure on offspring development, beginning during the neonatal period and with several assessments during the first year of life, utilizing physiological measures in combination with parent reports and behavioural observations, both at home and in more intensive laboratory settings, will be an important task for the future to enhance our knowledge of potential pathways from prenatal smoke exposure to the development of behaviour disorders, such as ADHD.
Tissue-specific activation of cardiac angiotensin converting enzyme in experimental heart failure.

In addition to the circulating renin-angiotensin system, recent data demonstrate the existence of tissue renin-angiotensin systems that may be important in cardiovascular homeostasis. However, the relative activities of the circulating and tissue renin-angiotensin systems have not been examined previously in pathophysiological states, such as congestive heart failure. The present study was performed to examine the status of plasma and tissue angiotensin converting enzyme (ACE) activities in compensated experimental heart failure induced by coronary artery ligation in the rat. Three groups of male Sprague-Dawley rats were examined: 1) nonoperated rats (NO, n = 5), 2) sham-operated rats (SO, n = 5), and 3) heart failure rats (HF, n = 11). Rats were studied an averaged of 85 days postoperatively. In HF animals, plasma renin concentration and serum ACE activities were not different compared with NO and SO control animals. Cardiac ACE activity was 50% greater in the right ventricle than the interventricular septum in NO and SO rats. Both right ventricular and interventricular septal ACE activity increased approximately twofold in HF animals as compared with NO and SO groups (p less than 0.05). In contrast, pulmonary, aortic, and renal ACE activities were not altered in HF rats compared with control animals. A positive correlation existed between the histopathological size of myocardial infarction and the level of right ventricular ACE activity (r = 0.75, p less than or equal to 0.05). Such a relation between infarct size and either serum or noncardiac tissue ACE activities was not observed. (ABSTRACT TRUNCATED AT 250 WORDS)
Mobile Privacy: Users' Expectations About the Behavior of Mobile Apps

Many tools have been proposed in the literature to analyze the behavior of mobile applications regarding user data collection. However, these tools do not take into consideration the users’ perception of what they think is collected and the purpose of such collection. In this sense, this paper proposes a privacy approach applied to the mobile context that considers the users’ expectations about their data collection and usage on smartphones. This work presents results of an experiment conducted with 163 Android users which goal was to understand the users’ expectations regarding the behavior of mobile apps and how that impacts their subjective feelings. Our results suggest that most users did not know which of their private data were collected by mobile applications and tended to be more comfortable when they were informed beforehand which data a mobile app would need access to and why.
A Diverse Dataset for Pedestrian Detection

Convnets have enabled significant progress in pedestrian detection recently, but there are still open questions regarding suitable architectures and training data. We revisit CNN design and point out key adaptations, enabling plain FasterRCNN to obtain state-of-the-art results on the Caltech dataset. To achieve further improvement from more and better data, we introduce CityPersons, a new set of person annotations on top of the Cityscapes dataset. The diversity of CityPersons allows us for the first time to train one single CNN model that generalizes well over multiple benchmarks. Moreover, with additional training with CityPersons, we obtain top results using FasterRCNN on Caltech, improving especially for more difficult cases (heavy occlusion and small scale) and providing higher localization quality.
Pharmacodynamics of the Type II Calcimimetic Compound Cinacalcet HCl

Calcimimetic compounds, which activate the parathyroid cell Ca2+ receptor (CaR) and inhibit parathyroid hormone (PTH) secretion, are under experimental study as a treatment for hyperparathyroidism. This report describes the salient pharmacodynamic properties, using several test systems, of a new calcimimetic compound, cinacalcet HCl. Cinacalcet HCl increased the concentration of cytoplasmic Ca2+ ([Ca2+]i) in human embryonic kidney 293 cells expressing the human parathyroid CaR. Cinacalcet HCl (EC50 = 51 nM) in the presence of 0.5 mM extracellular Ca2+ elicited increases in [Ca2+]i in a dose- and calcium-dependent manner. Similarly, in the presence of 0.5 mM extracellular Ca2+, cinacalcet HCl (IC50 = 28 nM) produced a concentration-dependent decrease in PTH secretion from cultured bovine parathyroid cells. Using rat medullary thyroid carcinoma 6-23 cells expressing the CaR, cinacalcet HCl (EC50 = 34 nM) produced a concentration-dependent increase in calcitonin secretion. In vivo studies in rats demonstrated cinacalcet HCl is orally bioavailable and displays approximately linear pharmacokinetics over the dose range of 1 to 36 mg/kg. Furthermore, this compound suppressed serum PTH and blood-ionized Ca2+ levels and increased serum calcitonin levels in a dose-dependent manner. Cinacalcet was about 30-fold more potent at lowering serum levels of PTH than it was at increasing serum calcitonin levels. The S-enantiomer of cinacalcet (S-AMG 073) was at least 75-fold less active in these assay systems. The present findings provide compelling evidence that cinacalcet HCl is a potent and stereoselective activator of the parathyroid CaR and, as such, might be beneficial in the treatment of hyperparathyroidism.
Nanoparticle Drug- and Gene-eluting Stents for the Prevention and Treatment of Coronary Restenosis

Percutaneous coronary intervention (PCI) has become the most common revascularization procedure for coronary artery disease. The use of stents has reduced the rate of restenosis by preventing elastic recoil and negative remodeling. However, in-stent restenosis remains one of the major drawbacks of this procedure. Drug-eluting stents (DESs) have proven to be effective in reducing the risk of late restenosis, but the use of currently marketed DESs presents safety concerns, including the non-specificity of therapeutics, incomplete endothelialization leading to late thrombosis, the need for long-term anti-platelet agents, and local hypersensitivity to polymer delivery matrices. In addition, the current DESs lack the capacity for adjustment of the drug dose and release kinetics appropriate to the disease status of the treated vessel. The development of efficacious therapeutic strategies to prevent and inhibit restenosis after PCI is critical for the treatment of coronary artery disease. The administration of drugs using biodegradable polymer nanoparticles as carriers has generated immense interest due to their excellent biocompatibility and ability to facilitate prolonged drug release. Despite the potential benefits of nanoparticles as smart drug delivery and diagnostic systems, much research is still required to evaluate potential toxicity issues related to the chemical properties of nanoparticle materials, as well as to their size and shape. This review describes the molecular mechanism of coronary restenosis, the use of DESs, and progress in nanoparticle drug- or gene-eluting stents for the prevention and treatment of coronary restenosis.
Haemolysis of various mammalian erythrocytes in sodium chloride, glucose and phosphate-buffer solutions

Mouse, rat, rabbit, hamster, cow, pig, sheep, guineapig, dog and human erythrocytes were studied. A 0·9% or stronger solution of sodium chloride completely prevented haemolysis; sheep and pig erythrocytes appeared the more fragile, while human and dog erythrocytes were not haemolized in concentrations of 0·4% or more. Haemolysis of human, rabbit, cow, hamster, guineapig, pig and sheep erythocytes was not observed in solutions of 0·4% or more of glucose. Except for sheep, human and dog erythrocytes, haemolysis was depressed in rate but not completely prevented by phosphate-buffer solution of pH 7·0.
Hardware-in-the-Loop Simulation for the Development of an Experimental Linear Drive

Linear drives (LDs) are designed to meet industrial applications like factory automation, material testing, packaging, pumping, and stamping. Because of the complexity of LDs, it is very important to analyze the dynamics and characteristics of the controlled systems before actual testing. The purpose of this paper is to build a hardware-in-the-loop (HIL) simulator that can provide an effective platform for developing and testing real-time LD systems. The HIL system comprises of a dynamical friction model, a dSPACE control system, and a human-machine interface. The developed system is tested by a proportional-integral-derivative controller.
Treatment Integrity of Interventions With Children in the School Psychology Literature from 1995 to 2008

Abstract. Increased accountability in education has resulted in a focus on implementing interventions with strong empirical support. Both student outcome and treatment integrity data are needed to draw valid conclusions about intervention effectiveness. Reviews of the literature in other fields (e.g., applied behavior analysis, prevention science) suggest that most researchers fail to report treatment integrity data. The purpose of this study was to review the treatment integrity data reported in all experimental intervention studies published in four school psychology journals between 1995 and 2008. Results indicate that a majority of published studies do not include a definition of the independent variable and half do not include quantitative treatment integrity data.
ICASE Report No . 93-50 191510 IC S 2 O Years ofExcellence SURROGATES FOR NUMERICAL SIMULATIONS ; OPTIMIZATION OF EDDY-PROMOTER HEAT EXCHANGERS

Although the advent of fast and inexpensive parallel computers has rendered numerous previously intractable calculations feasible, many numerical simulations remain too resource-intensive to be directly inserted in engineering optimization efforts. An attractive alternative to direct insertion considers models for computational systems: the expensive simulation is evoked only to construct and validate a simplified input-output model; this simplified inputoutput model then serves as a simulation surrogate in subsequent engineering optimization studies. We present here a simple "Bayesian-validated" statistical framework for the construction, validation, and purposive application of static computer simulation surrogates. As an example, we consider dissipationtransport optimization of laminar-flow eddy-promoter heat exchangers: parallel spectral element Navier-Stokes calculations serve to construct and validate surrogates for the flowrate and Nusselt number; these surrogates then represent the originating Navier-Stokes equations in the ensuing design process. 1This work was supported by DARPA Grant N00014-91-J-1889; ONR Grant N0001490-J-4124; ONR Grant N00014-89-J-1610; and by the National Aeronautics and Space Administration under NASA Contract No. NASl-19480 while the author was in Engineering (ICASE), NASA Langley Research Center, Hampton, VA 23681. 111 PRIECF.DIN6 PAGE BLANK NOT FILMED