Miracle-dz/UniFAR-FTUs huggingface dataset:
Coagulase-Negative Staphylococci

SUMMARY The definition of the heterogeneous group of coagulase-negative staphylococci (CoNS) is still based on diagnostic procedures that fulfill the clinical need to differentiate between Staphylococcus aureus and those staphylococci classified historically as being less or nonpathogenic. Due to patient- and procedure-related changes, CoNS now represent one of the major nosocomial pathogens, with S. epidermidis and S. haemolyticus being the most significant species. They account substantially for foreign body-related infections and infections in preterm newborns. While S. saprophyticus has been associated with acute urethritis, S. lugdunensis has a unique status, in some aspects resembling S. aureus in causing infectious endocarditis. In addition to CoNS found as food-associated saprophytes, many other CoNS species colonize the skin and mucous membranes of humans and animals and are less frequently involved in clinically manifested infections. This blurred gradation in terms of pathogenicity is reflected by species- and strain-specific virulence factors and the development of different host-defending strategies. Clearly, CoNS possess fewer virulence properties than S. aureus, with a respectively different disease spectrum. In this regard, host susceptibility is much more important. Therapeutically, CoNS are challenging due to the large proportion of methicillin-resistant strains and increasing numbers of isolates with less susceptibility to glycopeptides.
Automated Vocabulary Acquisition and Interpretation in Multimodal Conversational Systems

Motivated by psycholinguistic findings that eye gaze is tightly linked to human language production, we developed an unsupervised approach based on translation models to automatically learn the mappings between words and objects on a graphic display during human machine conversation. The experimental results indicate that user eye gaze can provide useful information to establish such mappings, which have important implications in automatically acquiring and interpreting user vocabularies for conversational systems.
Progression of Symptoms in Women Alcoholics: Comparison of Jellinek's Model with Two Groups

In 1952 Jellinek presented a model for the symptom progression of alcoholism in men. Neither Jellinek nor subsequent investigators made any attempts to extend his progression to women alcoholics. James, in 1975, studied this association, but the report of her results was descriptive and not statistical. The current study compared Jellinek's model with the progression reported by James and with a progression reported for a sample obtained by the authors. The authors did not obtain a significant correlation between the data of Jellinek and James but did for Jellinek and the authors' sample and between the authors' sample and James's.
Pulsatile thyrotropin release and thyroid function in acromegalics before and during subcutaneous octreotide infusion.

The pulsatile secretion of TSH was studied in eight patients with active acromegaly before treatment and after 1 month of therapy consisting of the sc infusion of 300 micrograms octreotide/day. Mean GH levels decreased from 37.1 +/- 7.2 to 5.2 +/- 1.4 mU/L (P = 0.002). Insulin-like growth factor-I levels decreased from 82.9 +/- 8.8 to 37.8 +/- 9.8 nmol/L (P less than 0.01) and normalized in five of the eight patients. In one patient TSH levels were undetectable before and during octreotide therapy. In the other seven patients, Cluster analysis revealed 11.9 +/- 0.8 pulses/24 h, with a mean pulse width of 81 +/- 4.6 min, a mean pulse height of 1.33 +/- 0.42 mU/L, and a mean pulse increment of 0.36 +/- 0.12 mU/L. During octreotide therapy these pulse parameters remained unchanged. Pulse height and amplitude increased significantly during the night (i.e. from 2000-0800 h) in both untreated and treated patients. The acrophase was unchanged by therapy. During therapy T3 levels decreased from 2.05 +/- 0.17 nmol/L to 1.44 +/- 0.08 nmol/L (P = 0.001), while rT3 levels increased from 0.14 +/- 0.02 nmol/L to 0.19 +/- 0.03 nmol/L (P less than 0.05). Plasma T4 levels remained unchanged. From these studies we conclude that the TSH pulse generator is unchanged in active acromegaly and apparently unaffected by chronic octreotide infusions.
Piles, tabs and overlaps in navigation among documents

Navigation among documents is a frequent, but ill supported activity. Overlapping or tabbed documents are widespread, but they offer limited visibility of their content. We explore variations on navigation support: arranging documents with tabs, as overlapping windows, and in piles. In an experiment we compared 11 participants' navigation with these variations and found strong task effects. Overall, overlapping windows were preferred and their structured layout worked well with some tasks. Surprisingly, tabbed documents were efficient in tasks requiring simply finding a document. Piled documents worked well for tasks that involved visual features of the documents, but the utility of recency or stable ordering of documents was task dependent. Based on the results, we discuss the effects of spatial arrangement, visibility, and task-dependency, and suggest areas for future research on document navigation and its support by piling.
The mobile devices and its mobile learning usage analysis

The usage of mobile devices for mobile learning is becoming increasingly popular. There is a new brand of students in the universities now-a-days who are easily connected to technology and innovative mobile devices. We attempt to do an analysis on a survey done with university students on mobile device usage for mobile learning purposes. This is to find the learning trends within the student community so that some of these popular practices could be encouraged to enhance learning among the student community. Both the quantitative and qualitative approaches are adopted in the analysis. The results are discussed and conclusions drawn in the end.
MEI4 – a central player in the regulation of meiotic DNA double‐strand break formation in the mouse

The formation of programmed DNA double‐strand breaks (DSBs) at the beginning of meiotic prophase marks the initiation of meiotic recombination. Meiotic DSB formation is catalyzed by SPO11 and their repair takes place on meiotic chromosome axes. The evolutionarily conserved MEI4 protein is required for meiotic DSB formation and is localized on chromosome axes. Here, we show that HORMAD1, one of the meiotic chromosome axis components, is required for MEI4 localization. Importantly, the quantitative correlation between the level of axis‐associated MEI4 and DSB formation suggests that axis‐associated MEI4 could be a limiting factor for DSB formation. We also show that MEI1, REC8 and RAD21L are important for proper MEI4 localization. These findings on MEI4 dynamics during meiotic prophase suggest that the association of MEI4 to chromosome axes is required for DSB formation, and that the loss of this association upon DSB repair could contribute to turning off meiotic DSB formation.
Longitudinal study of the diagnosis of components of the metabolic syndrome in individuals with binge-eating disorder.

BACKGROUND Binge-eating disorder may represent a risk factor for the metabolic syndrome. OBJECTIVE The objective was to assess longitudinally the relation between binge-eating disorder and components of the metabolic syndrome. DESIGN At 2.5 and 5 y of follow-up, 134 individuals with binge-eating disorder and 134 individuals with no history of eating disorders, who were frequency-matched for age, sex, and baseline body mass index (BMI), were interviewed during the follow-up interval regarding new diagnoses of 3 metabolic syndrome components: hypertension, dyslipidemia, and type 2 diabetes. RESULTS A comparison of individuals with and without a binge-eating disorder in analyses adjusted for age, sex, baseline BMI, and interval BMI change had hazard ratios (95% CIs) for reporting new diagnoses of metabolic syndrome components of 2.2 (1.2, 4.2; P = 0.023) for dyslipidemia, 1.5 (0.76, 2.9; P = 0.33) for hypertension, 1.6 (0.77, 3.9; P = 0.29) for type 2 diabetes, 1.7 (1.1, 2.6; P = 0.023) for any component, and 2.4 (1.1, 5.7; P = 0.038) for > or =2 components. CONCLUSION Binge-eating disorder may confer a risk of components of the metabolic syndrome over and above the risk attributable to obesity alone. This trial was registered at www.clinicaltrials. gov as NCT00777634.
A group randomized trial to improve safe use of nonsteroidal anti-inflammatory drugs.

OBJECTIVE To determine whether audit/feedback and educational materials improve adherence to recommendations for laboratory monitoring and cytoprotective agents to detect and prevent adverse events caused by nonsteroidal anti-inflammatory agents (NSAIDs). STUDY DESIGN Controlled, cluster-randomized trial. METHODS Physicians commonly prescribing NSAIDs were identified within a large managed care organization and randomized to a control or an intervention group (audit/feedback with peer-derived benchmarks and continuing medical education). Medical records were examined 10 months before and after the intervention for clinical data and receipt of complete blood count (CBC), creatinine testing, and cytoprotective agents (process measures). Primary analysis compared intervention versus control physicians among those who initially performed below a peer-derived benchmark. General estimating equations accounted for patient clustering. RESULTS Of 101 physicians initially randomized, 85 remained eligible (38 internists, 36 family physicians, 11 rheumatologists) postintervention. Mean percent change in performance between intervention and control physicians for CBC monitoring was 16% versus 10%; for creatinine monitoring, 0% versus 17%; and use of cytoprotective agents, -3% versus -1%. None of these changes were significant. Rheumatology specialty, number of NSAID prescriptions and physician visits, and patient risk factors for NSAID-related toxicity were more strongly associated with improved safety practices than the intervention. CONCLUSIONS Audit/feedback and educational materials had no observed effect on improving NSAID-related safety practices. Potentially contributing factors include high baseline performance (ceiling effect), dilution of the intervention effect by case mix and provider factors, nonreceipt of intervention materials, and diverse indications for lab tests.
Millimeter-Wave Communication with Out-of-Band Information

Configuring the antenna arrays is the main source of overhead in mmWave communication systems. In high mobility scenarios, the problem is exacerbated, as achieving the highest rates requires frequent link reconfiguration. One solution is to exploit spatial congruence between signals in different frequency bands and extract mmWave channel parameters with the aid of side information obtained in another band. In this article we propose the concept of out-of-band information aided mmWave communication. We analyze different strategies to leverage information derived from sensors or from other communication systems operating at sub-6 GHz bands to help configure the mmWave communication link. The overhead reductions that can be obtained when exploiting out-of-band information are characterized in a preliminary study. Finally, the challenges associated with using out-of-band signals as a source of side information at mmWave are analyzed in detail.
Do Bells Affect Behaviour and Heart Rate Variability in Grazing Dairy Cows?

In alpine regions cows are often equipped with bells. The present study investigated the impact of wearing a bell on behaviour and heart rate variability in dairy cows. Nineteen non-lactating Brown-Swiss cows with bell experience were assigned to three different treatments. For 3 days each, cows were equipped with no bell (control), with a bell with inactivated clapper (silent bell) or with a functional bell (functional bell). The bells weighed 5.5 kg and had frequencies between 532 Hz and 2.8 kHz and amplitudes between 90 and 113 dB at a distance of 20 cm. Data were collected on either the first and third or on all 3 days of each treatment. Whereas duration of rumination was reduced with a functional bell and a silent bell compared with no bell, feeding duration was reduced with a silent bell and was intermediate with a functional bell. Head movements were reduced when wearing a silent bell compared with no bell and tended to be reduced when wearing a functional compared to no bell. With a functional bell, lying duration was reduced by almost 4 hours on the third day of treatment compared with the first day with a functional bell and compared with no bell or a silent bell. All additional behavioural measures are consistent with the hypothesis of a restriction in the behaviour of the cows wearing bells, although this pattern did not reach significance. There was no treatment effect on heart rate variability, suggesting that the bells did not affect vago-sympathetic balance. An effect of experimental day was found for only 1 out of 10 behavioural parameters, as shown by a decrease in lying with a functional bell on day 3. The results indicate behavioural changes in the cows wearing a bell over 3 days, without indication of habituation to the bell. Altogether, the behavioural changes suggest that the behaviour of the cows was disturbed by wearing a bell. If long-lasting, these effects may have implications for animal welfare.
Methodology of Transdisciplinarity

In this article, I will describe the methodology of transdisciplinarity. My analysis will be divided in several parts: what means “beyond disciplines”; the distinction between multidisciplinarity, interdisciplinarity, indisciplinarity, and transdisciplinarity; the definition of disciplinary boundaries; the axioms of the methodology of transdisciplinarity: the notion of “levels of Reality”; the logic of included middle; and the universal interdependence. I will conclude by asserting that we are at the threshold of a New Renaissance.
Applications of geostatistics and Markov models for logo recognition

Spatial covariances based on geostatistics are extracted as representative features of logo or trademark images. These spatial covariances are different from other statistical features for image analysis in that the structural information of an image is independent of the pixel locations and represented in terms of spatial series. We then design a classifier in the sense of hidden Markov models to make use of these geostatistical sequential data to recognize the logos. High recognition rates are obtained from testing the method against a public-domain logo database.
Contribution of the Highly Conserved EaeH Surface Protein to Enterotoxigenic Escherichia coli Pathogenesis

ABSTRACT Enterotoxigenic Escherichia coli (ETEC) strains are among the most common causes of diarrheal illness worldwide. These pathogens disproportionately afflict children in developing countries, where they cause substantial morbidity and are responsible for hundreds of thousands of deaths each year. Although these organisms are important targets for enteric vaccines, most development efforts to date have centered on a subset of plasmid-encoded fimbrial adhesins known as colonization factors and heat-labile toxin (LT). Emerging data suggest that ETEC undergoes considerable changes in its surface architecture, sequentially deploying a number of putative adhesins during its interactions with the host. We demonstrate here that one putative highly conserved, chromosomally encoded adhesin, EaeH, engages the surfaces of intestinal epithelial cells and contributes to bacterial adhesion, LT delivery, and colonization of the small intestine.
Stroke Monitoring on a National Level: PERFECT Stroke, a Comprehensive, Registry-Linkage Stroke Database in Finland

Background and Purpose— Stroke databases are established to systematically evaluate both the treatment and outcome of stroke patients and the structure and processes of stroke services. Comprehensive data collection on this common disease is resource-intensive, and national stroke databases often include only patients from selected hospitals. Here we describe an alternative national stroke database. Methods— We established a nationwide stroke database with multiple administrative registry linkages at the individual-patient level. Information on comorbidities; treatments before, during, and after stroke; living status; recurrences; case fatality; and costs were collected for each hospital-treated stroke patient. Results— The current database includes 94 316 patients with incident stroke between January 1999 and December 2007, with follow-up until December 2008. Annually, 10 500 new patients are being added. One-year recurrence was 13% and case fatality was 27% during the study period. In 2007, 86% of patients survived 1 month and 77% were living at home at 3 months, but the proportion treated in stroke centers (62%) or with nationally recommended secondary preventive medication after ischemic stroke (49%) was still suboptimal. Conclusions— In comparison with other national stroke databases, our method enables higher coverage and more thorough follow-up of patients. Information on long-term recurrences, case fatality, or costs is not often included in national stroke databases. Our database has low maintenance costs, but it lacks detailed data on in-hospital processes. Use of national administrative data, where such linkage is possible, saves resources, achieves high rates of long-term follow-up, and allows for comprehensive monitoring of the burden of the disease.
Real-time adaptation of augmented-reality games for optimizing player satisfaction

A first endeavor for optimizing player satisfaction in augmented-reality games through the dasiaPlaywarepsila physical interactive platform is presented in this paper. Constructed user models, reported in the literature, map individual playing characteristics to reported entertainment preferences of augmented-reality game players. An adaptive mechanism then adjusts controllable game parameters in real-time in order to improve the entertainment value of the game for the player. The basic approach presented here applies gradient ascent to such a model to reveal the direction toward games of higher entertainment value while a rule-based system exploits the derivative information to adjust specific game parameters to augment the entertainment value. Those adjustments take place frequently during the game in small time intervals that maintain the constructed model's accuracy. Performance of the adaptation mechanism is evaluated using a game survey experiment. Results reveal that children show a notable preference for the adaptive versus the static Bug-Smasher (dasiaPlaywarepsila test-bed) game variant even when simple adaptive approaches like the one proposed are used. The limitations and the use of the methodology as a baseline effective adaptive mechanism to entertainment augmentation are discussed.
Reliability and Preventive Maintenance of Ducted Wind Turbines

This paper presents a reliability life analysis and preventive maintenance schedule for ducted wind turbines. Ducted wind turbines (DWT) are an emerging segment of the renewable energy industry with innovations that promise reliable, efficient, low-cost energy for consumer and small business markets. Many attempts have been made to build viable ducted turbines over the last century, but until recently none have succeeded commercially. Optimal shroud and blade designs are the focus of most engineering research to improve performance and efficiency, however, we hypothesize that an equally important key to the long-term success of small wind innovations is reliability analysis. For consumers and companies who want to efficiently maximize the lifespan of DWTs, this has significant ramifications. Operating beyond service life can result in catastrophic component failure and high replacement costs, making the technology economically infeasible. Our approach is focused on the analysis of 3.5 kW D3 turbines manufactured by Ducted Wind Turbines, Inc. We develop a component-level reliability analysis using ASTM E3159 and a consumer-level preventative maintenance schedule including failure modes and life estimates. Future research can use these findings to guide options for DWT life extension as well as localized maintenance solutions meant to reduce operational costs while preserving energy output.
Do dental students have a neutral working posture?

BACKGROUND Dentists are susceptible to Musculoskeletal Disorders (MSDs) due to prolonged static postures. To prevent MSDs, working postures of dental students should be assessed and corrected in early career life. OBJECTIVE This study estimated the risk of developing musculoskeletal disorders in dental students using Rapid Upper Limb Assessment (RULA) tool. METHODS A number of 103 undergraduate dental students from fourth and fifth academic years participated. Postures of these students were assessed using RULA tool while working in the dental clinic. They also answered a questionnaire regarding their knowledge about postural dental ergonomic principles. RESULTS The majority of the students (66%) were at intermediate and high risk levels to develop MSDs and their postures needed to be corrected. There was no significant correlation between RULA score and gender, academic year and different wards of dental clinics. There was no significant correlation between knowledge and RULA scores. CONCLUSIONS Dental students did not have favorable working postures. They were at an intermediate to high risk for developing MSDs which calls for a change in their working postures. Therefore students should be trained with ergonomic principles and to achieve the best results, ergonomic lessons should be accompanied by practice and periodical evaluations.
The Effects of Lifestyle Modification on Glycemic Levels and Medication Intake: The Rockford CHIP

The diabetes epidemic has been accompanied by a similarly drastic increase in obesity. Although the relationship between the two developments is a matter of debate, both are presumably caused by changes in dietary habits and an increasingly sedentary modern lifestyle (7;8). Compelling evidence has shown that lifestyle changes can effectively prevent or delay the occurrence of type 2 diabetes (9-12).
Normalization of blood lactate as early end-point of polytrauma treatment.

BACKGROUND The main aim of the early treatment of polytrauma is recovery of patient's physiological functions. The early achievement of therapeutic goals, mainly adequate tissue perfusion and repayment of oxygen debt, are postulated. The aim of the study was to confirm whether blood lactate level as a quantifier of oxygen deficit, as well as normalization of blood lactate level within the first 24 hours, have an impact on the mortality and morbidity of seriously injured patients. METHODS Sixty-nine mechanically ventilated patients with a severe trauma and organ dysfunction defined according to SOFA score and ISS >17, age >15 years, were enrolled into this retrospective study. 8 patients died within first 24 hours, 8 patients did not reach serum lactate level above 2 mmol/l on admission to hospital. The hypothesis that normalization of serum lactate level within 24 hours is related to lower mortality and morbidity, was assessed. Reduced mortality and morbidity were represented by lower severity of multi-organ dysfunction, the highest SOFA score during hospitalization, lower incidence of sepsis, number of days in ICU and artificial ventilation. RESULTS The association between severity of multi-organ failure (p=0.0006), mortality (p=0.0022) and repayment of oxygen debt was confirmed. Hypothesis of sepsis incidence was not confirmed (p=0.34). The association between number of days on artificial ventilation and number of days in ICU to repayment of oxygen debt was not confirmed either. Multivariate significant factors were age, GCS, ISS and SOFA score on patient's admission. CONCLUSION The patients, who repaid oxygen debt within first 24 hours, have lower morbidity and mortality (Tab. 6, Ref. 19).