Miracle-dz/UniFAR-FTUs huggingface dataset:
Adaptation of AHRQ Patient Safety Indicators for Use in ICD-10 Administrative Data by an International Consortium

Objective: The Agency for Healthcare Research and Quality (AHRQ) developed Patient Safety Indicators (PSIs) for use with ICD-9-CM data. Many countries have adopted ICD-10 for coding hospital diagnoses. We conducted this study to develop an internationally harmonized ICD-10 coding algorithm for the AHRQ PSIs. Methods: The AHRQ PSI Version 2.1 has been translated into ICD-10-AM (Australian Modification), and PSI Version 3.0a has been independently translated into ICD-10-GM (German Modification). We converted these two country-specific coding algorithms into ICD-10-WHO (World Health Organization version) and combined them to form one master list. Members of an international expert panel-including physicians, professional medical coders, disease classification specialists, health services researchers, epidemiologists, and users of the PSI-independently evaluated this master list and rated each code as either "include," "exclude," or "uncertain," following the AHRQ PSI definitions. After summarizing the independent rating results, we held a face-to-face meeting to discuss codes for which there was no unanimous consensus and newly proposed codes. A modified Delphi method was employed to generate a final ICD-10 WHO coding list. Results: Of 20 PSIs, 15 that were based mainly on diagnosis codes were selected for translation. At the meeting, panelists discussed 794 codes for which consensus had not been achieved and 2,541 additional codes that were proposed by individual panelists for consideration prior to the meeting. Three documents were generated: a PSI ICD-10-WHO version-coding list, a list of issues for consideration on certain AHRQ PSIs and ICD-9-CM codes, and a recommendation to WHO to improve specification of some disease classifications. Conclusion: An ICD-10-WHO PSI coding list has been developed and structured in a manner similar to the AHRQ manual. Although face validity of the list has been ensured through a rigorous expert panel assessment, its true validity and applicability should be assessed internationally.
Reflections on the value of autistic participation in a tri‐national teacher‐training project through discourses of acceptance, othering and power

The Transform Autism Education (TAE) project is a tri‐national teacher training scheme involving Greece, Italy and the UK, whose purpose is to set up training projects to facilitate the educational inclusion of autistic children. Running over three years from 2014 to 2017, the involvement of autistic participants has been the source of some discussion. Here, TAE team members Wood and Milton reflect on narratives of participation, acceptance and struggle which emerged during a workshop they ran in Greece. Derived from 11 non‐autistic and two autistic participants, and analysed via discourse analysis, these stories suggest a high value placed on autistic participation by non‐autistic TAE team members, but an unwitting tendency to ‘other’ autistic people and a lack of awareness of the power differential. Meanwhile, as the autistic team members describe how educational and social participation can be achieved, the implications for autism education researchers and practitioners are discussed. [ABSTRACT FROM AUTHOR]
Opportunistic Routing Protocols in Wireless Ad Hoc Networks Using Directional Antennas ⋆

MORE (MAC-independent Opportunistic Routing & Encoding) could increase network throughput by using network coding. On the other hand, directional antenna has better power eﬃciency and introduce the possibility of space diversity. In this paper, the authors try to combine directional antenna with opportunistic routing protocols and tried to use Network Simulator version2 to simulate it. The results show that there is an optimal lobe width for each particular circumstance and that under this optimal condition the throughput of opportunistic routing with directional antenna is much higher
On-off switching patterns for smart LED lighting

This paper formulates a new communication problem for smart LED lighting sys tems designed for light effect control. It introduces the key requirements imposed on the design of the LED driving sequences, which include multiple access, arbi trary duty cycle and no disturbance caused on the normal illumination function. We propose a class of orthogonal sequences that meets these requirements.
Intelligent Autonomic Strategy to Attacks in Network Infrastructure Protection: Feedback Methods to IDS, Using Policies, Alert Filters and Firewall Packet Filters for Multiple Protocols

The intrusion detection systems (IDSs) currently in use are designed to monitor potential attacks in networks by triggering alerts. However these alerts consist of high volumes of false positives, triggered by suspicious but normal, benign connections. In this paper we discuss false positives and their impact on intrusion detection and response. Then we propose a novel approach for an efficient intelligent detection and response using "network quarantine channels" (NQCs). The NQC is defined as subnet zones that respond to packets as they are diverted to its hosts for analysis before being permitted into the internal network. The innovative approach includes feedback mechanisms involving adaptive rules, alert filters and policies of the IDS network sensors for various protocols. The effect is the enhancement of the capability of the IDS to detect threats and benign attacks
Optimal Tuning of Memristor Conductance Variation in Spiking Neural Networks for Online Unsupervised Learning

In unsupervised learning (UL)-oriented spiking neural network (SNN) designs, the initial conductance variation of the synapses is usually necessary, with which temporally differentiated responses of the output neurons can be achieved given the same input patterns, in order to implement the important lateral inhibition function. We take a lithium silicate memristor as an example and demonstrate through a motion-style recognition task that, without regulating the initial conductance variation of memristor synapses, several types of errors will occur: too large conductance variance leads to the deactivation of some output neurons and the incomplete learning of the motion routes, while too small variance causes duplicated learnings of the same pattern. By tuning the memristor conductance variance through the forming voltages, it is found that the UL capacity can be optimized, indicating a promising approach to enhance the UL performance of a memristor-based SNN.
Draft Genome Sequence of Ochrobactrum intermedium Strain SA148, a Plant Growth-Promoting Desert Rhizobacterium

ABSTRACT Ochrobactrum intermedium strain SA148 is a plant growth-promoting bacterium isolated from sandy soil in the Jizan area of Saudi Arabia. Here, we report the 4.9-Mb draft genome sequence of this strain, highlighting different pathways characteristic of plant growth promotion activity and environmental adaptation of SA148.
Synthesis of Reactive Switching Protocols From Temporal Logic Specifications

We propose formal means for synthesizing switching protocols that determine the sequence in which the modes of a switched system are activated to satisfy certain high-level specifications in linear temporal logic (LTL). The synthesized protocols are robust against exogenous disturbances on the continuous dynamics and can react to possibly adversarial events (both external and internal). Finite-state approximations that abstract the behavior of the underlying continuous dynamics are defined using finite transition systems. Such approximations allow us to transform the continuous switching synthesis problem into a discrete synthesis problem in the form of a two-player game between the system and the environment, where the winning conditions represent the high-level temporal logic specifications. Restricting to an expressive subclass of LTL formulas, these temporal logic games are amenable to solutions with polynomial-time complexity. By construction, existence of a discrete switching strategy for the discrete synthesis problem guarantees the existence of a switching protocol that can be implemented at the continuous level to ensure the correctness of the nonlinear switched system and to react to the environment at run time.
Towards an Ontology of Collaboration Patterns

The concept of patterns and pattern languages has been applied in different application domains like software engineering, human computer interaction, and pedagogy. In the area of Collaborative Working Environments (CWE) there are different understandings on what collaboration patterns are and how they can be described and defined. Collaboration patterns are specified at different levels of granularity and in relation to different application contexts. In this article, after introducing the general idea of patterns and its application in the CWE domain, we present an approach for creating a layered ontology in order to integrate collaboration patterns of different granularities and at different levels of abstraction.
Transforming Growth Factor β1/Smad4 Signaling Affects Osteoclast Differentiation via Regulation of miR-155 Expression

Transforming growth factor β1 (TGFβ1)/Smad4 signaling plays a pivotal role in maintenance of the dynamic balance between bone formation and resorption. The microRNA miR-155 has been reported to exert a significant role in the differentiation of macrophage and dendritic cells. The goal of this study was to determine whether miR-155 regulates osteoclast differentiation through TGFβ1/Smad4 signaling. Here, we present that TGFβ1 elevated miR-155 levels during osteoclast differentiation through the stimulation of M-CSF and RANKL. Additionally, we found that silencing Smad4 attenuated the upregulation of miR-155 induced by TGFβ1. The results of luciferase reporter experiments and ChIP assays demonstrated that TGFβ1 promoted the binding of Smad4 to the miR-155 promoter at a site located in 454 bp from the transcription start site in vivo, further verifying that miR-155 is a transcriptional target of the TGFβ1/Smad4 pathway. Subsequently, TRAP staining and qRT-PCR analysis revealed that silencing Smad4 impaired the TGFβ1-mediated inhibition on osteoclast differentiation. Finally, we found that miR-155 may target SOCS1 and MITF to suppress osteoclast differentiation. Taken together, we provide the first evidence that TGFβ1/Smad4 signaling affects osteoclast differentiation by regulation of miR-155 expression and the use of miR-155 as a potential therapeutic target for osteoclast-related diseases shows great promise.
Machine Translation within One Language as a Paraphrasing Technique Online

We present a method for improving machine translation (MT) evaluation by targeted paraphrasing of reference sentences. For this purpose, we employ MT systems themselves and adapt them for translating within a single language. We describe this attempt on two types of MT systems – phrase-based and rule-based. Initially, we experiment with the freely available SMT system Moses. We create translation models from two available sources of Czech paraphrases – Czech WordNet and the Meteor Paraphrase tables. We extended Moses by a new feature that makes the translation targeted. However, the results of this method are inconclusive. In the view of errors appearing in the new paraphrased sentences, we propose another solution – targeted paraphrasing using parts of a rule-based translation system included in the NLP framework Treex.
Morphological appearance of the cryopreserved mouse blastocyst as a tool to identify the type of cryoinjury.

BACKGROUND If it were possible to deduce the mechanism of injury in cryopreserved embryos by their appearance, it would help to optimize cryopreservation protocols. METHODS Mouse blastocysts were treated so that they were damaged by the six types of cryoinjuries listed below, and their appearance was observed at recovery in sucrose solution and a modified phosphate-buffered saline (PB1), and after culture for 1 and 24 h. RESULTS (i) Intracellular ice: the embryos shrank normally in sucrose solution, but swelled in PB1 and collapsed after culture. (ii) Chemical toxicity of the cryoprotectant: the embryos looked normal in sucrose solution and PB1. After 1 h of culture, however, the blastomeres showed decompaction and degenerated thereafter. If the toxicity was extremely high, embryos looked nearly normal in PB1, but the surface of the cytoplasm was wrinkled as if they were "fixed". (iii) Osmotic swelling: the embryos looked normal in PB1, but after culture they shrank. (iv) Osmotic shrinkage: the embryos swelled in PB1, and then collapsed. (v) Fracture damage: the zona pellucida of the embryos was dissected. (vi) Extracellular ice: the zona of the embryos was elongated. CONCLUSIONS It was often possible to deduce the type of injury that had occurred in cryopreserved embryos from their appearance at recovery and during subsequent culture. This may help to improve cryopreservation protocols for embryos of many species, including man.
Discovery of Potent Kisspeptin Antagonists Delineate Physiological Mechanisms of Gonadotropin Regulation

Neurons that produce gonadotropin-releasing hormone (GnRH) are the final common pathway by which the brain regulates reproduction. GnRH neurons are regulated by an afferent network of kisspeptin-producing neurons. Kisspeptin binds to its cognate receptor on GnRH neurons and stimulates their activity, which in turn provides an obligatory signal for GnRH secretion, thus gating down-stream events supporting reproduction. We have developed kisspeptin antagonists to facilitate the direct determination of the role of kisspeptin neurons in the neuroendocrine regulation of reproduction. In vitro and in vivo studies of analogues of kisspeptin-10 with amino substitutions have identified several potent and specific antagonists. A selected antagonist was shown to inhibit the firing of GnRH neurons in the brain of the mouse and to reduce pulsatile GnRH secretion in female pubertal monkeys; the later supporting a key role of kisspeptin in puberty onset. This analog also inhibited the kisspeptin-induced release of luteinizing hormone (LH) in rats and mice and blocked the postcastration rise in LH in sheep, rats, and mice, suggesting that kisspeptin neurons mediate the negative feedback effect of sex steroids on gonadotropin secretion in mammals. The development of kisspeptin antagonists provides a valuable tool for investigating the physiological and pathophysiological roles of kisspeptin in the regulation of reproduction and could offer a unique therapeutic agent for treating hormone-dependent disorders of reproduction, including precocious puberty, endometriosis, and metastatic prostate cancer.
A new prosodic phrasing model for indian language telugu

Prosodic phrasing is an important and more difﬁcult a problem for Indian languages, as the Indian language scripts use very little or no punctuation. This paper reports a preliminary attempt on data-driven modeling of prosodic phrase boundary prediction for the Indian language Telugu. In an effort to identify meaningful features that affect the prosodic phrasing, a new feature, namely mopheme tag , is deﬁned. A Classiﬁcation and Regression Tree (CART) based data-driven phrasing model is developed for the prosodic phrase boundary prediction and the usefulness of the morpheme tag feature is further demonstrated in an evaluation process. The phrasing model developed has been implemented in an Indian language Text-to-Speech synthesis system [1] being developed within Festival framework [2].
Reassortant H9N2 Influenza Viruses Containing H5N1-Like PB1 Genes Isolated from Black-Billed Magpies in Southern China

H9N2 influenza A viruses have become endemic in different types of terrestrial poultry and wild birds in Asia, and are occasionally transmitted to humans and pigs. To evaluate the role of black-billed magpies (Pica pica) in the evolution of influenza A virus, we conducted two epidemic surveys on avian influenza viruses in wild black-billed magpies in Guangxi, China in 2005 and characterized three isolated black-billed magpie H9N2 viruses (BbM viruses). Phylogenetic analysis indicated that three BbM viruses were almost identical with 99.7 to 100% nucleotide homology in their whole genomes, and were reassortants containing BJ94-like (Ck/BJ/1/94) HA, NA, M, and NS genes, SH/F/98-like (Ck/SH/F/98) PB2, PA, and NP genes, and H5N1-like (Ck/YN/1252/03, clade 1) PB1 genes. Genetic analysis showed that BbM viruses were most likely the result of multiple reassortments between co-circulating H9N2-like and H5N1-like viruses, and were genetically different from other H9N2 viruses because of the existence of H5N1-like PB1 genes. Genotypical analysis revealed that BbM viruses evolved from diverse sources and belonged to a novel genotype (B46) discovered in our recent study. Molecular analysis suggested that BbM viruses were likely low pathogenic reassortants. However, results of our pathogenicity study demonstrated that BbM viruses replicated efficiently in chickens and a mammalian mouse model but were not lethal for infected chickens and mice. Antigenic analysis showed that BbM viruses were antigenic heterologous with the H9N2 vaccine strain. Our study is probably the first report to document and characterize H9N2 influenza viruses isolated from black-billed magpies in southern China. Our results suggest that black-billed magpies were susceptible to H9N2 influenza viruses, which raise concerns over possible transmissions of reassortant H9N2 viruses among poultry and wild birds.
Chronic pain coping styles in patients with herniated lumbar discs and coexisting spondylotic changes treated surgically: Considering clinical pain characteristics, degenerative changes, disability, mood disturbances, and beliefs about pain control

Background Pain catastrophizing, appraisals of pain control, styles of coping, and social support have been suggested to affect functioning in patients with low back pain. We investigated the relation of chronic pain coping strategies to psychological variables and clinical data, in patients treated surgically due to lumbar disc herniation and coexisting spondylotic changes. Material/Methods The average age of study participants (n=90) was 43.47 years (SD 10.21). Patients completed the Polish versions of the Chronic Pain Coping Inventory-42 (PL-CPCI-42), Beck Depression Inventory (BDI-PL), Coping Strategies Questionnaire (CSQ-PL), Beliefs about Pain Control Questionnaire (BPCQ-PL), and Roland-Morris Disability Questionnaire (RMQ-PL). Results In the PL-CPCI-42 results, resting, guarding and coping self-statements were frequently used as coping strategies (3.96 SD 1.97; 3.72 SD 1.72; 3.47 SD 2.02, respectively). In the CSQ-PL domains, catastrophizing and praying/hoping were frequently used as coping strategies (3.62 SD 1.19). The mean score obtained from the BDI-PL was 11.86 SD 7.23, and 12.70 SD 5.49 from the RMDQ-PL. BPCQ-PL results indicate that the highest score was in the subscale measuring beliefs that powerful others can control pain (4.36 SD 0.97). Exercise correlated significantly with beliefs about internal control of pain (rs=0.22). We identified associations between radiating pain and guarding (p=0.038) and between sports recreation and guarding (p=0.013) and task persistence (p=0.041). Conclusions Back pain characteristics, depressive mood, disability, and beliefs about personal control of pain are related to chronic LBP coping styles. Most of the variables related to advancement of degenerative changes were not associated with coping efforts.
Advection-dominated Accretion Flows in the Kerr Metric. I. Basic Equations

We write and solve equations describing steady state, optically thin, advection-dominated accretion onto a Kerr black hole. The mean flow, described by the relativistic fluid equations, is axisymmetric and vertically averaged. The effect of turbulence in the flow is represented by a viscous shear stress. Our treatment differs in several important ways from earlier work: we use a causal prescription for the shear stress; we do not assume that the relativistic enthalpy is unity (this is important for rapidly rotating holes); and we use a relativistic equation of state. We present several representative solutions and use them to evaluate the importance of relativistic effects, to check our approximations, and to evaluate the robustness of the input physics. Detailed properties of the solutions are described in an accompanying paper.
The Spontaneously Diabetic Torii Rat: An Animal Model of Nonobese Type 2 Diabetes with Severe Diabetic Complications

The Spontaneously Diabetic Torii (SDT) rat is an inbred strain of Sprague-Dawley rat and recently is established as a nonobese model of type 2 diabetes (T2D). Male SDT rats show high plasma glucose levels (over 700 mg/dL) by 20 weeks. Male SDT rats show pancreatic islet histopathology, including hemorrhage in pancreatic islets and inflammatory cell infiltration with fibroblasts. Prior to the onset of diabetes, glucose intolerance with hypoinsulinemia is also observed. As a result of chronic severe hyperglycemia, the SDT rats develop profound complications. In eyes, retinopathy, cataract, and neovascular glaucoma are observed. Proliferative retinopathy, especially, resulting from retinal neovascular vessels is a unique characteristic of this model. In kidney, mesangial proliferation and nodular lesion are observed. Both peripheral neuropathy such as decreased nerve conduction velocity and thermal hypoalgesia and autonomic neuropathy such as diabetic diarrhea and voiding dysfunction have been reported. Osteoporosis is another complication characterized in SDT rat. Decreased bone density and low-turnover bone lesions are observed. Taking advantage of these features, SDT rat has been used for evaluating antidiabetic drugs and drugs/gene therapy for diabetic complications. In conclusion, the SDT rat is potentially a useful T2D model for studies on pathogenesis and treatment of diabetic complications in humans.
QTL Mapping of a High Protein Digestibility Trait in Sorghum bicolor

Compared with other cereal grains, Sorghum bicolor shows lower protein digestibility. The low digestibility is thought to result from disulfide cross linking in the β- and γ-kafirins. In contrast, the single recessive high digestibility/high lysine content (HD) mutation which confers greater grain digestibility exists in sorghum that is thought to result from reduced accumulation of γ-kafirin that allows greater access to the high digestible α-kafarin fraction. In an effort to both clearly define the molecular basis for the HD trait and develop tools to improve the introgression of this difficult-to-screen trait, this study focuses on mapping the QTLs linked to this trait. While the HD trait has been defined as a single recessive gene, our results uncovered that two major QTLs on chromosome 1 are associated with protein digestibility—one QTL (locus 1 from the HD parent) unfavorably affects digestibility and one QTL (locus 2 from the HD parent) only 20 cM away favorably affects digestibility. A contrast analysis between genotypic groups at these two loci shows that a higher level of protein digestibility may be obtained when this linkage in repulsion is broken and favorable alleles are allowed to recombine.