Miracle-dz/UniFAR-FTUs huggingface dataset:
Variation in Clinical Practice of Intravenous Thrombolysis in Stroke in the Netherlands

In the Netherlands in 2010, 11% of patients with ischemic stroke received intravenous thrombolysis (IVT), varying from 4 to 26% between hospitals. The aim of this study was to investigate variation in clinical practice and organization of IVT in relationship to performance and outcome. In all 84 Dutch hospitals performing IVT, a stroke neurologist was approached using a web-based survey. The response rate was 82%. The study showed considerable variation. For example, door-to-needle time ranged from 25 to 80 min. High blood pressure was actively lowered before performing IVT by 57% of neurologists, while 35% chose to wait. 28% started IVT without knowledge of laboratory results. Better follow-up data are needed to see whether this variation results in differences in outcome.
Algorithm Partitioning including Optimized Data-Reuse for Processor Arrays

This paper describes a method for algorithm partitioning through which affine indexed algorithms are transformed to Processor Arrays. Former design flows start with a spacetime transformation which we omit completely. Therefore, we are able to consider the constraints of a target architecture at the beginning of our design flow. We show our method for three different partitioning schemes and emphasize on the derivation of a schedule. The principle of an optimized data-reuse is introduced for our partitioning methodology. Under this aspect, we give a parameterized Processor Array for the 2D FIR filter algorithm.
An integrated framework for the dependability evaluation of distributed mobile applications

Current distributed mobile systems are usually characterized by a huge number of nodes, different network domains, different applications running, variability of the users' behavior, and dynamicity and heterogeneity of the communication networks. A typical example can be found in the automotive context, considering car-to-car and car-to-infrastructure communication scenarios. In this paper we propose a model-based approach for the dependability evaluation of distributed applications in a mobile environment. The final Multiple Phased System model representing the analyzed mobile scenario is automatically derived from high-level UML specifications through a sequence of model transformation steps. The evaluation workflow is based on i) a hierarchical modelling approach that analyzes the system at different levels, namely communication, architecture, application and user level; ii) a time-based system decomposition identifying different phases for different user activities and environment conditions.
Optimal Signal Sampling Configuration for MEMS INS/GPS Navigation

For vehicle navigation, Global Positioning System (GPS) provides long term accurate measurements, but only when a direct line of sight to four or more satellites exists. Inertial navigation systems (INS), on the other hand, are self contained sensors that can provide short term measurements. The integration of the two systems can effectively provide continuous navigation data even during GPS signal outages. Traditional INSs are bulky and expensive, and therefore, can not be used for daily civilian applications. With the evolution of MEMS technology, MEMS-based INS sensors are evolving into more accurate, compact and inexpensive units. Hence, there is a growing interest in exploring the capabilities of these sensors in the field of vehicle navigation. Most of the research is targeted towards finding the best error models and integration techniques that can reduce the high drift and errors associated with these sensors. One of the important aspects of this integration is the optimal configuration for sampling frequency, number of bits and time delay during recording of the various sensor outputs. The very low cost of the MEMS sensors makes the cost of the signal sampling, i.e. analog to digital conversion (ADC), an issue. These parameters will reduce the on-board memory requirement, speed up the computation and hence, significantly reduce the final cost to the consumers.
An unusual case of metastatic melanoma sensitive to chemotherapy and immunotherapy, with late immune escape in the brain.

The incidence of skin melanoma is increasing worldwide with little or no improvement in mortality despite intensive research and treatment. Following the appearance of distant metastases overall survival rarely exceeds one year. For metastatic disease, single agent chemotherapy with dacarbazine (DTIC) or temozolomide (TMZ) remains the standard of care and combination with cisplatin (CDDP) or biochemotherapy, including interleukin-2 and interferon-alpha, has failed to improve survival in randomized trials (1-3). Nevertheless, a role for the patients' immune system has long been advocated based on observations of spontaneous disease remissions and immune responses (4). Here, we report on an unusual course of metastatic melanoma with documentation of a tumor antigen-specific immune response and synergy with chemotherapy, as well as the subsequent intracranial tumor escape.
The mortality of bereavement: A review.

Increasingly in recent years researchers have focused on positive aspects of the experience of bereavement, emphasizing that it is a “growth experience,” that people are “resilient,” and that the illness metaphor should be abandoned in describing the consequences of grief. The chapters in this volume by Silverman and Worden, McCrae and Costa, and Shuchter and Zisook, to name only a few, underline this message. Yet the reason that so much research has focused on bereavement is because the loss of a loved one is associated with extreme mental and physical suffering, not for everyone, and not always lastingly, but for a significant minority. Even more disturbing are the statistics for mortality. Not only do some bereaved individuals fall ill following the loss of a loved one, but they also die. Given that fatal consequences occur for some bereaved, it is important to identify those who are vulnerable and to understand why they and not others succumb. A decade ago we reviewed the research on mortality (M. Stroebe, Stroebe, Gergen, & Gergen, 1981) and concluded that there was some evidence that bereavement results in excess mortality. However, the surveyed research suffered from many methodological shortcomings. In the meantime, much research has been done and much has been written about the bereavement-mortality relationship. The goals of this chapter, therefore, are to review the scientific evidence that is now available, examine subgroup differences that suggest high-risk categories, and review and evaluate theoretical explanations that could account for the bereavement-mortality relationship.
Decomposition Approach for Low-Rank Matrix Completion and Its Applications

In this paper, we describe a low-rank matrix completion method based on matrix decomposition. An incomplete matrix is decomposed into sub-matrices which are filled with a proposed trimming step and then are recombined to form a low-rank completed matrix. The divide-and-conquer approach can significantly reduce computation complexity and storage requirement. Moreover, the proposed decomposition method can be naturally incorporated into any existing matrix completion methods to attain further gain. Unlike most existing approaches, the proposed method is not based on norm minimization nor on SVD decomposition. This makes it possible to be applied beyond real domain and can be used in arbitrary fields, including finite fields. The effectiveness of our proposed method is demonstrated through extensive numerical results on randomly generated and real matrix completion problems and a concrete application-video denoising. The numerical experiments show that the algorithm can reliably solve a wide range of problems at a speed significantly faster than recent algorithms. In the proposed denoising approach, we present a patch-based video denoising algorithm by grouping similar patches and then formulating the problem of removing noise using a decomposition approach for low-rank matrix completion. Experiments show that the proposed approach robustly removes mixed noise such as impulsive noise, Poisson noise, and Gaussian noise from any natural noisy video. Moreover, our approach outperforms state-of-the-art denoising techniques such as VBM3D and 3DWTF in terms of both time and quality. Our technique also achieves significant improvement over time against other matrix completion methods.
An interconnection network that exploits locality of communication

Several patterns of structure and locality of communication among software components assigned to processors are considered. In each case, a mapping between components and processors is identified so that high-volume communication paths correspond to connections supported most efficiently by the interconnection network. It is shown that locality of communication can have a profound effect on the efficiency of communication in a multicomputer. Several types of multiprocessors and multicomputers being designed for applications in artificial intelligence are likely to exhibit locality of communication of a form suitable for use by such interconnection networks. <<ETX>>
The Use of Locally Normalized Cepstral Coefficients (LNCC) to Improve Speaker Recognition Accuracy in Highly Reverberant Rooms

We describe the ability of LNCC features (Locally Normalized Cepstral Coefficients) to improve speaker recognition accuracy in highly reverberant environments. We used a realistic test environment, in which we changed the number and nature of reflective surfaces in the room, creating four increasingly reverberant times from approximately 1 to 9 seconds. In this room, we re-recorded reverberated versions of the Yoho speaker verification corpus. The recordings were made using four speaker-to-microphone distances, from 0.32m to 2.56m. Experimental results for a speaker verification task suggest that LNCC features are an attractive alternative to MFCC features under such reverberant conditions, as they were observed to improve verification accuracy compared to baseline MFCC features in all cases where the reverberation time exceeded 1 second or with a greater speaker-microphone distance (i.e. 2.56 m).
THE REMOVAL OF H2S FROM PROCESS AIR BY DIFFUSION INTO ACTIVATED SLUDGE

Emissions of H2S from publicly owned treatment works is a serious problem, therefore collection and treatment of these emissions is essential. In this work, the performance of a bench scale activated sludge system used for the removal of H2S from foul air was investigated, and the effects of H2S concentration (5 to 50 ppmv) on COD reduction and biomass settleability were studied. After biomass acclimation, the reactor was operated in a continuous mode at a hydraulic retention time of 5 h and a mean cell residence time of 6 days. Results showed that COD and H2S removal were 93.5 and 94.5%, respectively. Furthermore, H2S concentration up to 50 ppmv did not significantly affect the COD reduction. H2S loading rates of up to 7.5 mgH2S g-1 MLSS d-1 were treated with greater than 94% efficiency. The only adverse effect of H2S that was observed was an increase in the sludge volume index at loading rates over 4.5 mgH2S g-1 MLSS d-1, at which bulking of the sludge occurred. Overall, the results indicate that H2S at concentrations usually emitted from wastewater treatment processes (lower than 50 ppmv), can be efficiently treated by diffusion into activated sludge without compromising the performance of the activated sludge process.
DNA Array Decoding from Nonlinear Measurements by Belief Propagation

We propose a signal recovery method using Belief Propagation (BP) for nonlinear Compressed Sensing (CS) and demonstrate its utility in DNA array decoding. In a CS DNA microarray, the array spots identify DNA sequences that are shared between multiple organisms, thereby reducing the number of spots required. The sparsity in DNA sequence commonality between different organisms translates to conditions that render Belief Propagation (BP) efficient for signal reconstruction. However, an excessively high concentration of target DNA molecules has a nonlinear effect on the measurements ¿ it causes saturation in the measurement intensities at the array spots. We use a modified BP to estimate the target signal coefficients since it is flexible to handle the nonlinearity unlike l1 decoding or other greedy algorithms and show that the original signal coefficients can be recovered from saturated measurements of their linear combinations.
Leadership and Academic Librarians

Introduction The History and Evolution of the Librarian in Higher Education The Development of the Academic Library in American Higher Education and the Role of the Academic Librarian by Beverly P. Lynch From Faculty to Librarian Materials Selection: An Element in the Professionalization of Librarianship by Raven Fonfa The Future, the Responsibility of Leaders The Library Director as a Campus Leader by Delmus E. Williams Visionary Leadership by Donald E. Riggs A New Paradigm of Leader Effectiveness for Academic Libraries: An Empirical Study of the Bass (1985) Model of Transformational Leadership by Rosie L. Albritton Leadership Roles in Non-Managerial Settings Public Services Librarians in the Academic Community: The Imperative for Leadership by Barbara I. Dewey Every Instructional Services Librarian a Leader: Leadership in the Small Academic Library by Janet M. Hurlbert Leading from Within: Leadership Within the Ranks of Academic Librarians by George Charles Newman Expatriate Librarians and the Challenge of National Culture by Kenneth J. Oberembt A Critique of Some Contemporary Conceptions of Re-engineering Based Library Leadership by Brian Champion The Professional Career and Leadership Behavior Leadership: In the Eye of the Beholder? by David R. Dowell The Advancement Dilemma of Academic Library Directors by George Charles Newman Post-leadership Career Paths for Academic Directors by George Charles Newman Other Academic Settings and Leadership Roles Leadership Roles in Other Academic Settings by Dennis E. Robison Choosing the College Presidency: Extending the Career Ladder by Elaine P. Adams An Academic Odyssey: Teacher, Librarian, Professor, Dean by Edward J. Jennerich On Becoming a Chief Information Officer in Academe: Evolving Roles of an Academic Librarian by H.E. Broadbent III The Complex Tapestry of a Library Life by Christie Koontz Bibliographic Essay Leadership in Librarianship by Rashelle S. Karp and Cindy Murdock Index
Mouse Mast Cell Tryptase mMCP-6 Is a Critical Link between Adaptive and Innate Immunity in the Chronic Phase of Trichinella spiralis Infection1

Although the innate immune function of mast cells in the acute phase of parasitic and bacterial infections is well established, their participation in chronic immune responses to indolent infection remains incompletely understood. In parasitic infection with Trichinella spiralis, the immune response incorporates both lymphocyte and mast cell-dependent effector functions for pathogen eradication. Among the mechanistic insights still unresolved in the reaction to T. spiralis are the means by which mast cells respond to parasites and the mast cell effector functions that contribute to the immunologic response to this pathogen. We hypothesized that mast cell elaboration of tryptase may comprise an important effector component in this response. Indeed, we find that mice deficient in the tryptase mouse mast cell protease-6 (mMCP-6) display a significant difference in their response to T. spiralis larvae in chronically infected skeletal muscle tissue. Mechanistically, this is associated with a profound inability to recruit eosinophils to larvae in mMCP-6-deficient mice. Analysis of IgE-deficient mice demonstrates an identical defect in eosinophil recruitment. These findings establish that mast cell secretion of the tryptase mMCP-6, a function directed by the activity of the adaptive immune system, contributes to eosinophil recruitment to the site of larval infection, thereby comprising an integral link in the chronic immune response to parasitic infection.
Characterization of a Neutralizing Monoclonal Antibody Directed at the Lipopolysaccharide of Chlamydia pneumoniae

ABSTRACT Identification of protective epitopes is one of the first steps in the development of a subunit vaccine. One approach to accomplishing this is to identify structures or epitopes by using monoclonal antibodies (MAb) that can attenuate infectivity in vitro and in vivo. To date attempts to use this approach with Chlamydia pneumoniae have failed. This report is the first description of a MAb directed to the lipopolysaccharide (LPS) of Chlamydiathat neutralizes both in vitro and in vivo the infectivity of C. pneumoniae. MAb CP-33, an immunoglobulin G2b (IgG2b), was identified from a fusion using splenocytes from mice immunized withC. pneumoniae TW-183. By Western blot analysis, MAb CP-33 exhibited genus-specific reactivity in that it recognized the LPSs ofC. pneumoniae, Chlamydia trachomatis, andChlamydia psittaci. MAb CP-33 did not react with 15 genera of gram-negative and gram-positive bacteria and Candida albicans. By using isolated LPS of Re mutants ofEscherichia coli, Salmonella enterica serovar Minnesota, and recombinants expressing the 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) transferase gene kdtA of C. trachomatis, MAb CP-33 was shown to require for binding the presence of the genus-specific trisaccharide epitope αKdo(2→8)αKdo(2→4)αKdo. By employing synthetic oligosaccharides and neoglycoconjugates in an enzyme immunoassay (EIA) and EIA inhibition, it was further shown that MAb CP-33 differed from the extensively investigated prototype chlamydial LPS MAb S25-23. Most likely, MAb CP-33 recognizes a conformational epitope in which the αKdo(2→8)αKdo(2→4)αKdo trisaccharide is an essential structural component. When tested in an in vitro neutralization assay, MAb CP-33 gave a 50% neutralization titer of 8 ng/ml against C. pneumoniae TW-183. However, this MAb did not neutralize other C. pneumoniae strains,C. trachomatis, or C. psittaci. C. pneumoniaeTW-183 was treated with either MAb CP-33 or a control IgG and then used to inoculate mice by the respiratory route. Five days after inoculation, there was a difference between the mice inoculated with the control IgG-treated inoculum and those inoculated with the MAb CP-33-treated organisms as to the number of mice infected as well as the number of inclusion-forming units recovered from lung cultures (P < 0.05). In summary, aChlamydia-specific LPS MAb was able to neutralize in vitro the infectivity of C. pneumoniae TW-183.
High-frequency callus induction and plant regeneration in Tripsacum dactyloides (L.)

SummaryA protocol for high-frequency callus, somatic embryogenesis, and plant regeneration for Tripsacum is described. Plants were regenerated from complete shoot meristems (3–4 mm) via organogenesis and embryogenesis. In organogenesis, the shoot meristems were cultured directly on a high cytokinin medium comprising 5–10 mgl−1 (22.2–44.4 μM) 6-benzyladenine (BA). The number of multiple shoots varied from six to eight from each meristem. The time required for production of plants from organogenesis was rapid (4–6 wk). In contrast, callus was induced on an auxin medium and continuously cultured on an auxin medium for production of somatic embryos. Prolific callus with numerous somatic embryos developed within 3–4 wk when cultured on an auxin medium containing 5 mgl−1 (22.6μM), 2,4-dichlorophenoxyacetic acid (2,4-D). The number of shoots induced varied from two to five per callus. Regardless of the cultivars used, the frequency of callus induction and plant regeneration was between 48% and 94%. The seed germination procedures also were modified and resulted in a maximum of 60–80% seed germination. Finally, the rate of T-DNA transfer to complete shoot meristems of Tripsacum was high on the auxin medium and was independent of whether super-virulent strains of Agrobacterium were used or not.
Spectral gap of doubly stochastic matrices generated from CUE

To a unitary matrix U we associate a doubly stochastic matrix M by taking the modulus squared of each element of U. To study the connection between onset of quantum chaos on graphs and ergodicity of the underlying Markov chain, specified by M, we study the limiting distribution of the spectral gap of M when U is taken from the Circular Unitary Ensemble and the dimension N of U is taken to infinity. We prove that the limiting distribution is degenerate: the gap tends to its maximal value 1. The shape of the gap distribution for finite N is also discussed.
An In Vitro Expansion System for Generation of Human iPS Cell-Derived Hepatic Progenitor-Like Cells Exhibiting a Bipotent Differentiation Potential

Hepatoblasts, hepatic stem/progenitor cells in liver development, have a high proliferative potential and the ability to differentiate into both hepatocytes and cholangiocytes. In regenerative medicine and drug screening for the treatment of severe liver diseases, human induced pluripotent stem (iPS) cell-derived mature functional hepatocytes are considered to be a potentially good cell source. However, induction of proliferation of these cells is difficult ex vivo. To circumvent this problem, we generated hepatic progenitor-like cells from human iPS cells using serial cytokine treatments in vitro. Highly proliferative hepatic progenitor-like cells were purified by fluorescence-activated cell sorting using antibodies against CD13 and CD133 that are known cell surface markers of hepatic stem/progenitor cells in fetal and adult mouse livers. When the purified CD13highCD133+ cells were cultured at a low density with feeder cells in the presence of suitable growth factors and signaling inhibitors (ALK inhibitor A-83-01 and ROCK inhibitor Y-27632), individual cells gave rise to relatively large colonies. These colonies consisted of two types of cells expressing hepatocytic marker genes (hepatocyte nuclear factor 4α and α-fetoprotein) and a cholangiocytic marker gene (cytokeratin 7), and continued to proliferate over long periods of time. In a spheroid formation assay, these cells were found to express genes required for mature liver function, such as cytochrome P450 enzymes, and secrete albumin. When these cells were cultured in a suitable extracellular matrix gel, they eventually formed a cholangiocytic cyst-like structure with epithelial polarity, suggesting that human iPS cell-derived hepatic progenitor-like cells have a bipotent differentiation ability. Collectively these data indicate that this novel procedure using an in vitro expansion system is useful for not only liver regeneration but also for the determination of molecular mechanisms that regulate liver development.