Miracle-dz/UniFAR-FTUs huggingface dataset:
Elimination of atrioventricular nodal reentrant tachycardia.

Elimination ofAtrioventricular Nodal Reentrant Tachycardia The report by Haissaguerre et all was very exciting because it demonstrated a new catheter ablation approach for the cure of atrioventricular (AV) nodal reentrant tachycardia while preserving transmission in the intrinsic "sinoventricular conduction system. " Haissaguerre et AI, however, use the term "P potential" and then provide a detailed description of the P potential without appropriate citation for the origin of this terminology. Although my article2 was cited four times in their report, it is not clearly denoted that I coined the term, described the histological/anatomic substrate, and also provided the first definitive electrophysiological description under various conditions. Of most concern, however, is that Haissaguerre et al's paper is misleading in understanding the physiological and clinical significance of the P potential. They described the P potential as either "They occupied the diastolic interval between atrial and ventricular electrograms" (p. 2163) or "At low-rate stimulation, the slow potentials occupied all (giving a continuum of electrograms) or some of the interval between the atrial and ventricular electrograms" (pp. 2165-2166). This is not the case, as evidenced by their figures. In reality, the P potential represents depolarization of the proximal AV bundle, which is the common anatomic input to the AV node.3 The P potential occurs only in the interval between depolarization of the atrium or the superior atrionodal bundle (during exposure to 10 mM potassium) and the atrioventricular node electrogram. The proximal AV bundle is also the common electric input to the AV node, because with transection of the proximal AV bundle/AV node connections, the S potential (which represents depolarization of the superior atrionodal bundle) and the P potential discharge sequentially at the sinus rate, but the AV node discharges spontaneously.2 Furthermore, transmission is rapid through the superior atrionodal bundle.2 The superior atrionodal bundle and the most distal region of the proximal AV bundle are analogous (similar in location and histologically) to the leftand right-going components of the AV node described in human hearts by Anderson et a14 as previously cited.3 The P potential has been recorded routinely (although not mentioned) in the human clinical tripole electrograms, which include the AV node electrogram (e.g., Damato et al,5 Figures 2-6), as cited in my paper.2 Also, it should be remembered that, although neither diagrams nor photodocumentation was provided, the first anatomic descriptions of the proximal AV bundle were given by Tawara in 19066 and later confirmed by Keith and Flack7 in 1907 for human heart and in other species including the dog.
Runtime implementation of modular radiance transfer

Real-time rendering of indirect lighting significantly enhances the sense of realism in video games. Unfortunately, previously including such effects often required time consuming scene dependent precomputation and heavy runtime computations unsuitable for low-end devices, such as mobile phones or game consoles. Modular Radiance Transfer (MRT) [Loos et al. 2011] is a recent technique that computes approximate direct-to-indirect transfer [Hašan et al. 2006; Kontkanen et al. 2006; Lehtinen et al. 2008] by warping and combining light transport, in real-time, from a small library of simple shapes. This talk focusses on implementation issues of the MRT technical paper, including how our run time is designed to scale across many different platforms, from iPhones to modern GPUs.
Severe maternal and fetal electrolyte imbalance in pregnancy after gastric surgery for morbid obesity. A case report.

BACKGROUND Gastric surgery for morbid obesity is considered a safe procedure with favorable effects on reproductive performance. Pregnancies after gastric restrictive operations are usually well tolerated by both mother and fetus. Some postoperative complications, however, do occur, although an association between such complications and adverse pregnancy outcomes has not been reported. CASE A 40-year-old woman had a successful gastric operation for weight reduction but developed chronic, low grade gastro-intestinal obstruction as a late complication of surgery. Subsequent pregnancies ended in late abortion or premature delivery. During her last pregnancy, reported here in detail, severe and life-threatening fetomaternal electrolyte imbalances developed. CONCLUSION Pregnancy following a gastric operation for morbid obesity may be complicated by severe metabolic disturbances that can jeopardize both the pregnant woman and her fetus. These pregnancy complications, which are related to the primary gastric surgery, are reported here for the first time.
Determinants of Equity Share Prices in India: A Panel Data Approach

The present study examines the fundamental determinants of share price in India. The study employs panel data consisting of annual time series data over the period 2006-2011 and cross-section data pertaining to 6 major sectors of the Indian economy, namely, Heavy and Manufacturing, Pharmaceutical, Energy, IT and ITES, Infrastructure and Banking. The panel data techniques, viz. Fixed Effects model and Random Effects model have been employed to investigate the objective. The empirical results reveal that the dividend per share has a negative and significant impact on the share price of manufacturing, pharmaceutical, energy and infrastructure sectors. These results are consistent with findings of Zahir and Khanna (1982), Malhotra (1987) and Sharma (2011), that dividend has influenced market price of share significantly in negative direction. The evidences show that earning per share and price-earnings ratio are being the crucial determinants of share prices of manufacturing, pharmaceutical sector, energy, infrastructure and commercial banking sectors. The findings indicate that size is being a significant factor in determining the share prices of all sectors under consideration except manufacturing. Moreover, the book value per share positively influences the share prices of pharmaceutical, energy, IT & ITES and Infrastructure. The present study confirms that performance of the fundamental ratios of the industry will be essential and immense helpful to investors and analysts in assessing the better stocks that belong to different industry groups.
What Price Coordination? The Efficiency-Enhancing Effect of Auctioning the Right to Play

A model is proposed to explain the results of recent experiments in which subjects repeatedly played a coordination game, with the right to play auctioned each period in a larger group. Subjects bid the market-clearing price to a level recoverable only in the efficient equilibrium and then converged to that equilibrium, although subjects playing the game without auctions converged to inefficient equilibria. The efficiency-enhancing effect of auctions is reminiscent of forward induction but is not explained by equilibrium refinements. The model explains it by showing how strategic uncertainty interacts with history-dependent learning dynamics to determine equilibrium selection. Copyright 1998 by American Economic Association.
Smad2 Decelerates Re-epithelialization during Gingival Wound Healing

During periodontal regeneration, inhibition of gingival downgrowth is necessary to promote migration of mesenchymal cells into the defects. Transforming growth factor (TGF)-β is a pleiotropic cytokine that has numerous cell functions, including regulation of epithelial growth. Recent studies have shown that Smad2, a downstream transcription factor of TGF-β, plays crucial roles in wound healing in the epithelia. Therefore, we investigated the effects of Smad2 overexpression on re-epithelialization of gingival wounds. Transgenic mice overexpressing smad2 driven by the keratin 14 promoter (k14-smad2) were confirmed to have significant Smad2 phosphorylation in gingival basal epithelia. Punch wounds were made in the palatal gingiva, and wound healing was assessed histologically for 7 days. Re-epithelialization was significantly retarded on day 2, while collagen deposition was enhanced on day 7 in k14-smad2 compared with wild-type mice. Moreover, expression of keratin 16 (K16), an indicator of keratinocyte migration, was significantly inhibited in wound-edge keratinocytes in k14-smad2. The inhibition of K16 coincided with the induction of Smad2 in the corresponding epithelia, while BrdU incorporation was unaffected. These results indicated that Smad2 has inhibitory effects in regulating keratinocyte migration during gingival wound healing. TGF-β/Smad2 signaling mediating alteration of K16 expression must be tightly regulated during periodontal regeneration.
Analysis of Possibilities for Using Recycled Concrete Aggregate in Concrete Pavement

: The present article describes the limits of using recycled concrete aggregate (denoted as RCA) in the top layer of concrete roads. The main aim of this work is to investigate the possibility of reuse of recycled aggregates obtained by crushing the old concrete roads as a building material in the new top layers of concrete pavements. The paper is based on gathering the current knowledge about how to use recycled concrete aggregate, suitability, and modification of the properties and its standards. Regulations are detailed and described especially for European Union and for Czech Republic
[Treatment of subclinical congenital toxoplasmosis by sulfadiazine and pyrimethamine continuously during 1 year: apropos of 46 cases].

UNLABELLED In France, most of children suffering from congenital toxoplasmosis have an infraclinic or moderate type at birth. This study aimed at evaluating, on the mid term, tolerance and results of postnatal treatment previously given in severe toxoplasmosis. METHODS A retrospective study considered 46 children with a mild or moderate congenital toxoplasmosis treated over 12 months with sulfadiazine-pyrimethamine and treatment was completed since three months. RESULTS Five children suffered from a lesion of chorioretinitis during treatment and two after. After a mean follow-up of 27.1 months, ten children (21.7% 95%CI [12.1-35.9]) had at least one ocular injury. Specific IgG titers and immune load were diminished to become almost non-existent at the end of the year of treatment (respectively p < 10(-5) and p = 0.0005). No thrombocytopenia was observed. Twenty-three children (50%) had at least one episode of neutropenia < 1000/mm3, 14 had only one, nine presented two or more installment. None was followed by an infection. CONCLUSION This therapeutic pathway is more demanding but shorter than those usually offered when associating pyrimethamine-sulfadiazine. Yet, it does give identical result on the mid term. Longer follow-up is needed to appreciate. Active molecule on cysts should be introduced.
New Modes of Governance and Democratic Accountability 1

Abstract This article raises the question of the link between new modes of governance and democratic accountability. Our definition of new modes of governance as modes refers to public policy-making that includes private actors and/or public policy-making by public actors that takes place outside legislative arenas, and which focuses on delimited sectoral or functional areas. We identify three different ways in which new modes of governance can be subjected to democratic control: parliamentary control, multi-stakeholder involvement and control through the public sphere and civil society at large. Building on a number of the illustrative insights from various empirical projects, we find that, in our cases at least, new modes of governance did not have a negative effect on existing patterns of democratic accountability. At the same time, neither multi-stakeholder policies nor the participation of civil society guarantee democratic accountability in the strict sense. We provide some evidence to the effect that, if institutionally linked to democratically elected governmental bodies – meaning, in this context, the European Parliament – it is more likely that negative externalities deriving from public policy-making in functionally segmented arenas of the European Union's multilevel polity will be dealt with in a more systematic way.
Brand Reposition Impact in the Internationalization of Brazilian Foot-Wear Companies: The Havaianas Case

New markets, needs, desires and opportunities seem to appear every day on the global stage. This also means an increase in the number of competitors, technological innovations and new purchase alternatives for the consumer. The conquest of these buyers’ preferences therefore becomes the purpose of many companies, to whom brand starts to be seen as an intangible asset – fundamental in attracting the attention of several interest groups; creating an emotional bond with the customer. The excessive focus given by many organizations to the products and services offered is often limited to their functional and technical characteristics, and has given them the appearance of simple commodities, without any added value. This paper intends to show how is possible to reverse this kind of situation: creating a strong brand, whether in the local or international sphere of action, based in the planning and implementation of integrated actions of the marketing mix variables. With a case study carried out together with Sao Paulo Alpargatas (specifically with their sandals business unit which manages the brand Havaianas), the factors that made them one of the biggest Brazilian icons abroad are studied: the associations developed; the communication strategy used; the new position achieved by the brand; and the implementation of a long-lasting strategy.
Dual mode control of inverter to integrate solar-wind hybrid fed DC-grid with distributed AC grid

This paper presents integration of solar-wind hybrid fed DC-grid to distributed AC grid. Generally, the renewable hybrid energy systems use two or more energy sources to supply power to the dc grid. In case of insufficient power generation or excessive load demand, in order to supply power to DC loads, it must integrate with AC grid. As dc loads increase in number, complexity increases and tighter voltage regulation is required. This paper presents dual mode control operation of inverter which integrates the solar and wind power fed dc bus to the single phase ac distribution system. The inverter can be operated in hysteresis current control when power is fed from DC grid to AC distributed grid and in AC-DC boost rectifier mode otherwise. The detailed operation of dual mode control of inverter is described in this paper. The effectiveness of the proposed system has been verified through simulation studies using MATLAB/SIMULINK.
Local IndustryEmployment Share and the Experiences of Displaced Workers

This paper examines how industries' share of employment in local labor markets affects displaced workers' re-employment, industry switching and earnings losses. A key result is that workers displaced from industries with low employment shares are more likely to switch industries after displacement. Earnings loss estimates indicate that for most workers, displacement from an industry that employs a smaller share of the local labor force is associated with larger earnings losses.
Evaluation of Contact Stress in Metal‐Backed Patellar Replacements

Significant wear-through and dissociation failures of metal-backed, point and line contact patellar replacements are associated with excessive contact stresses on the polyethylene-bearing surfaces. Analytical mathematical contact-stress analysis was used to evaluate various patellar component geometries under loading conditions consistent with walking, stair descent, and deep knee bends, respectively. Typical point- and line-contact patellar-surface geometries exceeded the manufacturer's recommended maximum permissible compressive stress level of 10 MPa by a factor greater than three, which also exceeds the yield stress of ultra-high, molecular-weight polyethylene. A metal-backed, rotating-bearing, area contact geometry patellar replacement maintained safe contact stress levels at less than half of the maximum permissible compressive stress level. These contact stress analyses predict early fatigue failure of all-polyethylene or metal-backed, point- and line-contact patellar replacements, while predicting long-term survival of area-contact, rotating-patellar replacements. Clinical evaluation of these various implants support the conclusions of these analyses. Contact stress analysis should precede any clinical use of patellar implants to avoid predictable failure mechanisms.
A Theoretical Approach to the Effect of Trade Union Immunities on Investment and Employment

The UK Trade Union Immunity Laws have been the subject of considerable political debate in recent years with the political parties differing markedly in their attitudes to the present status of labour contracts. In contrast to the political debate no positive economic analysis of the consequences of these laws exists on which one might base policy judgements. The purpose of this paper is to suggest one approach which provides a positive theoretical analysis of the effects of these laws on investment and employment. For our analysis the crucial feature of the law is that an employer cannot recover any losses suffered if a union withholds labour from his firm even if there is a written contract that labour will work for an agreed period at a given wage rate. This is a feature of UK collective bargaining which is unique amongst advanced countries (see Sachs (1979))'. There are several approaches one could take to analyse the effects of Trade Union Immunities (TUI). Put most generally, the critical reason for following the present approach is the view that one will gain most insight into the effects of TUI on investment and employment by looking at models where workers have an incentive to push home an ex post advantage that arises because shareholders are locked into specific capital levels. The model we analyse (a single investment opportunity where workers do not have access to perfect capital markets) is the extreme case of many models of this type. The notion which underlies the model is the following. A union is only able to extract a wage which is greater than the competitive wage, w, from a firm if they can threaten the firm with some strategy that 'hurts' shareholders. If the union can prevent production taking place then the shareholders are 'hurt' because they are the owners of capital, purchased at c per unit, which is lying idle. The more
Prevention of radiation-ind uced chromosome damage in mouse bone marrow by aqueous leaf extract of Chicorium intybus

60 Co γ-rays. Aqueous extract (50 and 100 mg/kg body wt) was administered orally just after irradiation. Bone marrow protection was evaluated by scoring the different types of individual aberrations and aberrant metaphases, 24hrs after irradiation. Significant reduction in number of aberrant cells and different type of aberrations was observed in treated group compared to irradiated untreated group of animals. The administration of aqueous leaf extract of Chicory to the animals showed significant reduction in micronucleus induction. The extract also possessed significant hydroxyl radical scavenging activity. The effectiveness of the drug to prevent chromosomal damage consequent to irradiation along with its high solubility in water, favor its application, in accidental radiation exposures and nuclear accidents.
Hemodynamic, Neural, and Humoral Mechanisms of Aortic Coarctation Hypertension in the Rat

Summary: The present study was designed: (a) to examine the contribution of the renin-angiotensin system (RAS) to elevated regional vascular resistance during the onset of aortic coarctation hypertension, and (b) to determine the role of angiotensin II (Ang II)-neural interactions during the maintenance of high arterial pressure (AP). In the first study, rats were instrumented chronically with miniaturized pulsed Doppler flow probes on the right renal and supetior mesenteric arteries 3 days prior to complete aortic ligation. After ligation, AP and renal and mesenteric vascular resistances increased significantly. In sham-ligated rats, small increases in AP and decreases in regional vascular resistances were observed. Captopril, administered 6 h postligation, reduced AP and regional vascular resistance in ligated rats to preligation levels, indicating that the RAS was responsible for these acute increases. In the second study, Ang II-neural interactions were examined by treating 12-to 14-day postligation hypertensive rats with captopril or with hexamethonium, a ganglionic blocker, followed by captopril. Depressor responses to captopril were also examined in aortic-ligated rats pretreated with hydralazine. Captopril alone and captopril after hydralazine caused similar reductions in AP (- 26 ± 2% and −27 ± 1%, respectively). After ganglionic blockade, the depressor responses to captopril were attenuated (−13 ± 2%). The marked differences in the efficacy of captopril to lower AP in the ganglionic-blocked group of rats suggested that the pressor actions of Ang II were mediated, in part, through indirect actions on the sympathetic nervous system.
Flat Whites: Who Gets Progression in the UK Café Sector?

The article examines the opportunities for, and barriers to, career progression in the UK cafe sector. The research finds that some workers are able to move up within organisations to reach managerial levels, regardless of their qualifications. However, the limited positions available, the nature of the work and low rewards mean that most workers either do not want progression or feel that they are unlikely to succeed.
Functional Genomic and Metabolic Studies of the Adaptations of a Prominent Adult Human Gut Symbiont, Bacteroides thetaiotaomicron, to the Suckling Period*

The adult human gut microbiota is dominated by two divisions of Bacteria, the Bacteroidetes and the Firmicutes. Assembly of this community begins at birth through processes that remain largely undefined. In this report, we examine the adaptations of Bacteroides thetaiotaomicron, a prominent member of the adult distal intestinal microbiota, during the suckling and weaning periods. Germ-free NMRI mice were colonized at birth from their gnotobiotic mothers, who harbored this anaerobic Gram-negative saccharolytic bacterium. B. thetaiotaomicron was then harvested from the ceca of these hosts during the suckling period (postnatal day 17) and after weaning (postnatal day 30). Whole genome transcriptional profiles were obtained at these two time points using custom B. thetaiotaomicron GeneChips. Transcriptome-based in silico reconstructions of bacterial metabolism and gas chromatography-mass spectrometry and biochemical assays of carbohydrate utilization in vivo indicated that in the suckling gut B. thetaiotaomicron prefers host-derived polysaccharides, as well as mono- and oligosaccharides present in mother's milk. After weaning, B. thetaiotaomicron expands its metabolism to exploit abundant, plant-derived dietary polysaccharides. The bacterium's responses to postnatal alterations in its nutrient landscape involve expression of gene clusters encoding environmental sensors, outer membrane proteins involved in binding and import of glycans, and glycoside hydrolases. These expression changes are interpreted in light of a phylogenetic analysis that revealed unique expansions of related polysaccharide utilization loci in three human alimentary tract-associated Bacteroidetes, expansions that likely reflect the evolutionary adaptations of these species to different nutrient niches.