Miracle-dz/UniFAR-FTUs huggingface dataset:
Computer Generated Orchestration: Towards Using Musical Timbre in Composition

Timbre is a musical attribute that has been largely discussed among the research community. However, there is still a lot to investigate, especially in regards to timbre and orchestration, which involves polyphonic timbre: a phenomenon that emerges from the mixture of instruments playing simultaneously. In this paper, we report on the development of a system capable of automatically analysing and classifying perceptual qualities of timbre within orchestral audio samples. This approach has been integrated in a computer-aided orchestration system for string ensemble. Our rationale for developing such a system is to create a means of incorporating musical timbre in the composition of music, which is often focused mainly on traditional Western music theory. Such developments could enrich creative music systems, and aid composers in their metier.
Contact frequency and cognitive health among older adults in Israel

ABSTRACT Objectives: The current study set out to examine the links between contact frequency with one's social network and cognitive health in later life. It assessed both direct and indirect pathways and the possible role of ethnicity in the effect of the social network on cognitive function. Method: We used data from adults aged 50 and above, which was collected in Israel as part of the Survey of Ageing, Retirement and Health (SHARE). A moderated mediation analysis was conducted to test the direct and indirect associations between contact frequency and cognitive function, as well as the moderation of these associations by population group. Three population groups were examined – veteran-Jews, Arabs and immigrants from the former Soviet Union. Results: Contact frequency with the close social milieu was found to be directly positively related to cognitive function. The association was also mediated by depressive symptoms, such that frequent contacts were linked to cognitive health via reduced depressive symptoms. This indirect link differed, however, among the three population groups. Conclusion: Contact frequency is important for cognitive health in the second half of life, and it operates both directly and by decreasing depressive symptoms. However, these links are not found among all ethnic groups and may, therefore, depend on the culture and social norms of each group and the meaning attributed to social ties.
Impacts of Mixed Use and Density on Utilization of Three Modes of Travel: Single-Occupant Vehicle, Transit, and Walking

Findings from an empirical analysis to test the impacts of land-use mix, population density, and employment density on the use of the singleoccupant vehicle (SOV), transit, and walking for both work trips and shopping trips are presented. The hypothetical relationships tested focused on whether there is a relationship between urban form and modal choice, whether this relationship exists when controlling for non-urban form factors, whether this relationship is linear or nonlinear, and whether a stronger relationship exists between modal choice and urban form when they are measured at both trip ends as opposed to either the origin or the destination. A review of the literature and experiences suggested that a fair amount of information is known about the impacts of density on mode choice. However, considerable debate exists over whether density itself is actually the causal stimulus or a surrogate for other factors. To address this issue a data base was developed with a comprehensive set of variables for which density may be a proxy, for example, demographics and level of service. This analysis employed a correlational research design in which mode choice was compared among census tracts with differing levels of density and mix. Findings from this research indicate that density and mix are both related to mode choice, even when controlling for non-urban form factors for both work trips and shopping trips. Furthermore, the relationship between population and employment density and mode choice for SOV, transit, and walking is nonlinear for both work and shopping trips. Transit usage and walking increase as density and land-use mix increase, whereas SOV usage declines. The findings from this research suggest that measuring urban form at both trip ends provides a greater ability to predict travel choices than looking at trip ends separately. The findings also suggest that increasing the level of land-use mix at the trip origins and destinations is also related to a reduction in SOV travel and an increase in transit and walking. This research is important because of recent policy initiatives at the federal, state, and local levels that state that it is no longer feasible to maintain access to opportunities in urban areas by increasing the mobility of SOVs. Among the commonly cited reasons are economics, new environmental legislation (e.g., the Clean Air Act Amendments of 1990), public opposition, changing demographics, and political pressure to reduce fuel consumption. Several urbanform strategies have been recommended to reduce dependence on driving alone. These strategies include increasing residential and employment densities and intermixing a variety of land uses (residential, employment, and commercial). Although these strategies would seem to enhance the viabilities of alternatives to SOVs, relatively little work has been conducted to test these relationships empirically.
Enzymatic Inactivation of Endogenous IgG by IdeS Enhances Therapeutic Antibody Efficacy

Endogenous plasma IgG sets an immunologic threshold that dictates the activity of tumor-directed therapeutic antibodies. Saturation of cellular antibody receptors by endogenous antibody limits antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). Here, we show how enzymatic cleavage of IgG using the bacterial enzyme IdeS can be utilized to empty both high and low affinity Fcγ-receptors and clear the entire endogenous antibody pool. Using in vitro models, tumor animal models as well as ex vivo analysis of sera collected during a previous clinical trial with IdeS, we show how clearing of competing plasma antibody levels with IdeS unblocks cellular antibody receptors. We show that therapeutic antibodies against breast cancer (trastuzumab), colon cancer (cetuximab), and lymphomas (rituximab and alemtuzumab) can be potentiated when endogenous IgG is removed. Overall, IdeS is shown to be a potent tool to reboot the human antibody repertoire and to generate a window to preferentially load therapeutic antibodies onto effector cells and thereby create an armada of dedicated tumor-seeking immune cells. Mol Cancer Ther; 16(9); 1887–97. ©2017 AACR.
Optimal nonlinear robust control of a boost converter

This paper deals with the control problem of a dc-dc boost converter whose operation takes place in an uncertain environment. The proposed nonlinear controller achieves the desired performance in a number of different situations. Uncertainties, unknown but bounded, are considered to be present in the load as well as in the input voltage. Effective control results as long as certain matching assumptions for the uncertainty are satisfied. If these assumptions are violated, a measure of mismatch is established that corresponds to residual uncertainty. An optimization problem is formulated that yields a threshold of the measure of mismatch which guarantees that maximum unmatched uncertainty can be tolerated.
Endocrine-disrupting chemicals, epigenetics, and skeletal system dysfunction: exploration of links using bisphenol A as a model system

Abstract Early life exposures to endocrine-disrupting chemicals (EDCs) have been associated with physiological changes of endocrine-sensitive tissues throughout postnatal life. Although hormones play a critical role in skeletal growth and maintenance, the effects of prenatal EDC exposure on adult bone health are not well understood. Moreover, studies assessing skeletal changes across multiple generations are limited. In this article, we present previously unpublished data demonstrating dose-, sex-, and generation-specific changes in bone morphology and function in adult mice developmentally exposed to the model estrogenic EDC bisphenol A (BPA) at doses of 10 μg (lower dose) or 10 mg per kg bw/d (upper dose) throughout gestation and lactation. We show that F1 generation adult males, but not females, developmentally exposed to bisphenol A exhibit dose-dependent reductions in outer bone size resulting in compromised bone stiffness and strength. These structural alterations and weaker bone phenotypes in the F1 generation did not persist in the F2 generation. Instead, F2 generation males exhibited greater bone strength. The underlying mechanisms driving the EDC-induced physiological changes remain to be determined. We discuss potential molecular changes that could contribute to the EDC-induced skeletal effects, with an emphasis on epigenetic dysregulation. Furthermore, we assess the necessity of intact sex steroid receptors to mediate these effects. Expanding future assessments of EDC-induced effects to the skeleton may provide much needed insight into one of the many health effects of these chemicals and aid in regulatory decision making regarding exposure of vulnerable populations to these chemicals.
Fetal Hemoglobin in the Maternal Circulation – Contribution of Fetal Red Blood Cells

Abstract The major hemoglobin (Hb) during fetal life is fetal Hb (Hb F). It is mostly replaced by adult Hbs before birth and during the first year of life. In adults, where Hb F comprises <2.0% of the total Hb, it is not homogenously distributed among the red blood cells (RBCs) but is concentrated in a few RBCs, termed F-cells. Interestingly, for reasons that are unclear, Hb F increases in the maternal circulation during pregnancy. This increased Hb F could have two potential origins that are not mutually exclusive: A) maternal origin, due to inducing environment of Hb F in the maternal erythroid precursors; B) fetal origin, due to fetal cells crossing the placenta and entering the maternal circulation. The question we present herein is whether the observed increased Hb F in the maternal circulation during pregnancy is, at least partially, derived from the fetal origin. Peripheral blood was obtained from normal neonates (1–3 days old), adult men and pregnant and non pregnant women. The RBCs were stained for Hb F and carbonic anhydrase (CA) using a fetal cell count kit and analyzed by flow cytometry. Fetal and adult F-cells were distinguished by their expression of Hb F and CA. Fetal F-cells were Hb F++/CA−, while adult F-cells were Hb F+/CA+. Comparing pregnant and non pregnant women samples (n = 10), we found six samples of pregnant women with 0.2–1.7% fetal cells, but none in the non pregnant group. These results support the possibility that at least part of the increase in Hb F during pregnancy is due to fetal cells entering the maternal circulation.
Experimental Drugs for Neuropathic Pain

Background: Neuropathic pain (NP) is an important public health problem and despite recent progress in the un-derstanding, diagnosis, pathophysiological mechanisms and the treatment of NP, many patients remain refractory to pharma-cotherapy. Objective: Currently used drugs have limited efficacy and dose-limiting adverse effects, and thus there is a substantial need for further development of novel medications for its treatment. Alternatively, drugs approved for use in diseases other than NP can be applied as experimental for NP conditions. This paper covers advances in the field of NP treatment. Results: The prime focus of this paper is on drugs with well-established pharmacological activity whose current therapeutic applications are distinct from NP. These drugs could be a potential novel treatment of NP. Data from preclinical studies and clinical trials on these experimental drugs are presented. The development of advanced methods of genomics enabled to pro-pose new targets for drugs which could be effective in the NP treatment. Conclusion: Experimental drugs for NP can be a treatment option which should be tailor-made for each individual on the basis of pain features, previous therapies, associated clinical conditions, recurrence of pain, adverse effects, contraindications and patients’ preferences. At present, there are only some agents which may have potential as novel treatments. Increasing knowledge about mechanisms underlying NP, mechanisms of drug action, as well as available data from preclinical and clin-ical studies make botulinum toxin A, minocycline, ambroxol, statins and PPAR agonists (ATx086001) promising potential future treatment options.
The pH-Responsive PacC Transcription Factor of Aspergillus fumigatus Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis

Destruction of the pulmonary epithelium is a major feature of lung diseases caused by the mould pathogen Aspergillus fumigatus. Although it is widely postulated that tissue invasion is governed by fungal proteases, A. fumigatus mutants lacking individual or multiple enzymes remain fully invasive, suggesting a concomitant requirement for other pathogenic activities during host invasion. In this study we discovered, and exploited, a novel, tissue non-invasive, phenotype in A. fumigatus mutants lacking the pH-responsive transcription factor PacC. Our study revealed a novel mode of epithelial entry, occurring in a cell wall-dependent manner prior to protease production, and via the Dectin-1 β-glucan receptor. ΔpacC mutants are defective in both contact-mediated epithelial entry and protease expression, and significantly attenuated for pathogenicity in leukopenic mice. We combined murine infection modelling, in vivo transcriptomics, and in vitro infections of human alveolar epithelia, to delineate two major, and sequentially acting, PacC-dependent processes impacting epithelial integrity in vitro and tissue invasion in the whole animal. We demonstrate that A. fumigatus spores and germlings are internalised by epithelial cells in a contact-, actin-, cell wall- and Dectin-1 dependent manner and ΔpacC mutants, which aberrantly remodel the cell wall during germinative growth, are unable to gain entry into epithelial cells, both in vitro and in vivo. We further show that PacC acts as a global transcriptional regulator of secreted molecules during growth in the leukopenic mammalian lung, and profile the full cohort of secreted gene products expressed during invasive infection. Our study reveals a combinatorial mode of tissue entry dependent upon sequential, and mechanistically distinct, perturbations of the pulmonary epithelium and demonstrates, for the first time a protective role for Dectin-1 blockade in epithelial defences. Infecting ΔpacC mutants are hypersensitive to cell wall-active antifungal agents highlighting the value of PacC signalling as a target for antifungal therapy.
Factors Associated with Poor Hemoglobin A1c Control in Patients with Type 2 Diabetes.

BACKGROUND The limited implementation of clinical pharmacy service programs and the lack of studies identifying barriers to achieve blood glucose control have all attributed to the increased proportion of type 2 diabetes patients who have poor glycemic control in Jordan. OBJECTIVE To explore factors associated with higher HbA1c in patients with type 2 diabetes in Jordan. METHODS Variables including socio-demographics, disease and treatment factors were collected from171 patients with type2 diabetes at an outpatient diabetes clinic in Amman. Validated questionnaires were used to assess medication adherence, self-care activities, diabetes knowledge and healthrelated quality of life in addition to data collected from medical records. After the single-predictor analysis, stepwise linear regression was performed to develop a model with variables that best predicted hemoglobin A1c. RESULTS Medication adherence was inversely associated with HbA1c values (β = -0.275; t = 2.666; P < 0.01), indicating better glycemic control. Receiving insulin therapy was also associated with less HbA1c values and better glycemic control (β = - 0.184; t = 2.080; P < 0.05). Patients who had one or more comorbid conditions (β = 0.215; t = 2.264; P < 0.05) and those with longer diabetes duration (β = 0.092; t = 1.339; P < 0.05) were found to have significantly higher HbA1c values. CONCLUSION Emphasizing medication adherence, particularly for patients with longer duration of diabetes and those with multiple comorbid diseases should be strongly considered in future diabetes management programs implemented to improve glycemic control in patients with type 2 diabetes.
Adapting Feedback to Individual Residents: An Examination of Preceptor Challenges and Approaches.

Background Feedback conversations between preceptors and residents usually occur in closed settings. Little is known about how preceptors address the challenges posed by residents with different skill sets, performance levels, and personal contexts. Objective This study explored the challenges that preceptors experienced and approaches taken in adapting feedback conversations to individual residents. Methods In 2015, 18 preceptors participated in feedback simulations portraying residents with variations in skill, insight, confidence, and distress, followed by debriefing of the feedback conversation with a facilitator. These interactions were recorded, transcribed, and analyzed using thematic and framework analysis. Results The preceptors encountered common challenges with feedback conversations, including uncertainty in how to individualize feedback to residents and how to navigate tensions between resident- and preceptor-identified goals. Preceptors questioned their ability to enhance skills for highly performing residents, whether they could be directive when residents had insight gaps, how they could reframe the perceptions of the overly confident resident, and whether they should offer support to emotionally distressed residents or provide feedback about performance. Preceptors adapted their approach to feedback, drawing on techniques of coaching for highly performing residents, directing for residents with insight gaps, mediation with overly confident residents, and mentoring with emotionally distressed residents. Conclusions Examining the feedback challenges preceptors encounter and the approaches taken to adapt feedback to individual residents can provide insight into how preceptors meet the challenges of competency-based medical education, in which frequent, focused feedback is essential for residents to achieve educational milestones and entrustable professional activity expectations.
Accuracy improvement in 3D laser scanner based on dynamic triangulation for autonomous navigation system

Autonomous navigation has been an important task in recent years to keep track of vehicles location, to provide safety and accuracy on its trajectory and to see their surroundings and predict if it is possible to travel across them. In this paper, a method to improve accuracy on laser vision systems based on dynamic triangulation for mobile robots is proposed. This laser vision system consists on a positioning laser, a scanning aperture and a fixed distance between them. The positioning laser points a laser beam over a surface and it is detected by the scanning aperture. The proposed method to improve accuracy on laser vision systems relies on the scanning aperture; current designs calculate the detection angle counting the pulses of a pulse train across a motor rotation. The disadvantage of this method is that the angular velocity of the motor may vary, resulting in an incorrect calculation of the angle of detection. In the proposed method, a new signal provided by an encoder is used to reduce the error generated by variations in angular velocity.
miR-30a inhibits epithelial-mesenchymal transition and metastasis in triple-negative breast cancer by targeting ROR1

Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype that lacks effective targeted therapies. In the present study, we revealed that the expression of miR-30a was significantly decreased in TNBC, and TNBC patients with low expression of miR-30a were associated with high histological grade and more lymph node metastasis. Moreover, we found that miR-30a suppressed TNBC cell epithelial-mesenchymal transition (EMT), as demonstrated by the overexpression of miR-30a which increased the expression of epithelial marker E-cadherin but decreased the expression of mesenchymal markers N-cadherin and vimentin. Furthermore, we demonstrated that overexpression of miR-30a significantly suppressed TNBC cell invasion and migration, as well as inhibited tumor growth and metastasis in vivo. More importantly, RTK-like orphan receptor 1 (ROR1) was predicted as the direct target of miR-30a, which was subsequently confirmed by luciferase assays. Forced expression of miR-30a in TNBC cells decreased ROR1 expression, whereas the overexpression of ROR1 reversed the suppressive effects of miR-30a in TNBC cell migration and invasion. Collectively, this study indicated that miR-30a functions as a tumor-metastasis suppressor miRNA in TNBC by directly targeting ROR1 and that miR-30a may serve as a novel therapeutic target for TNBC.
Inhibitory effects of luteolin‑4'‑O‑β‑D‑glucopyranoside on P2Y12 and thromboxane A2 receptor‑mediated amplification of platelet activation in vitro.

Platelet activation and subsequent accumulation at sites of vascular injury are central to thrombus formation, which is considered to be a trigger of several cardiovascular diseases. Callicarpa nudiflora (C. nudiflora) Hook is a traditional Chinese medicinal herb for promoting blood circulation by removing blood stasis. In our previous study, several compounds extracted from this herb, including luteolin‑4'‑O‑β‑D‑glucopyranoside (LGP), were revealed to exert inhibitory effects on adenosine diphosphate (ADP)‑induced platelet aggregation. The aim of present study was to confirm these antiplatelet effects and elucidate the potential mechanisms. Using a platelet‑aggregation assay, it was revealed that LGP significantly inhibited platelet aggregation induced by ADP, U46619 and arachidonic acid. It was also found that LGP exhibited marked inhibitory effects on the activation of αIIbβ3 integrin, the secretion of serotonin from granules, and the synthesis of thromboxane A2. In addition, the results showed that LGP suppressed Ras homolog family member A and phosphoinositide 3‑kinase/Akt/glycogen synthase kinase 3β signal transduction. Data from a radiolabeled ligand‑binding assay indicated that LGP exhibited apparent competing effects on thromboxane receptor (TP) and P2Y12 receptors. In conclusion, the data presented here demonstrated that LGP, a natural compound from C. nudiflora Hook, inhibited the development of platelet aggregation and amplification of platelet activation. These inhibitory effects may be associated with its dual‑receptor inhibition on P2Y12 and TP receptors.
El marco legislativo español para la contratación en el país de origen y la cooperación internacional con terceros países en el contexto de la política migratoria de la Unión Europea

The influx of immigrants from third countries in search of new opportunities in Spain makes it necessary for these flows to be regulated, in the exercise of state competence and in compliance with, and in respect of, European Union migration policy. Rational management of migration flows inevitably involves revising Spain’s foreign relations by strengthening international dialogue and concluding bilateral agreements with third countries. This study aims to analyse one of the main ways to access the Spanish labour market, namely the “collective management of hiring in country of origin”, as well as international cooperation between Spain and non-EU countries in the regulation and management of migration flows. Furthermore, Mobility Partnerships, a cooperation mechanism instigated by the European Union, are examined, with particular consideration given to the management of migration flows and labour migration from third countries. Those negotiated with Cape Verde and Morocco are of singular importance to Spain.