Miracle-dz/UniFAR-FTUs huggingface dataset:
An Efficient Data Storage Method of NoSQL Database for HEM Mobile Applications in IoT

In this work, an efficient data storage method of NoSQL database is proposed for mobile devices and Internet applications to monitor appliance status in a home environment in real-time, and a home energy management (HEM) mobile App for monitoring this information is also developed. An HBase cluster is constructed as a test bed for evaluation. The evaluation is conducted based on the developed APP accessing data stored by the proposed method, and it shows promising efficiency. This App together with the proposed method can help users better aware of the details of their home energy usage, and can even help other remote software agents/applications to deliver further useful applications, e.g. Large scale monitoring on demand response.
In search of the optimal surgical mortality.

Deeath by operation is feared by patient, family, and surgeon. Little positive can be said for the experience common to all experienced surgeons of informing family and colleagues that death resulted from a procedure undertaken in the hopes of enhancing life. Progress in surgery has commonly been gauged by a decline in operative mortality. A favorite mode of presentation of clinical series of surgical patients is to chronologically divide subgroups into early and late to emphasize improved outcomes. Most surgeons subscribe to the axiom that the ideal operative mortality is none at all. Surgeons have recently begun to reexamine the components of operative mortality. Computer technology facilitating prospective construction of clinical data bases has increased both the quantity and quality of information available for analysis. Series reconstructed with windows chosen to reflect the most favorable results have been replaced with fully inclusive series reporting annual mortality rates. Retrospective characterization of patients to exclude those with unusual but forgivable causes of death have been replaced by prospectively acquired data fully accounting for every patient within the total population. All of these influences have resulted in more accurate reporting of surgical mortality. For the first time in the history of cardiac surgery, more recent operative experience commonly shows no change, or even a slight increase, in mortality in comparison with prior years. It now appears increasingly difficult to further improve surgical mortality. Moreover, the public is becoming increasingly aware of mortalities of individual hospitals and surgeons. The time appears right to readdress the question, "What is the optimal cardiac surgical mortality? "
Development of Fast Dispersible Aceclofenac Tablets: Effect of Functionality of Superdisintegrants

Aceclofenac, a non-steroidal antiinflammatory drug, is used for posttraumatic pain and rheumatoid arthritis. Aceclofenac fast-dispersible tablets have been prepared by direct compression method. Effect of superdisintegrants (such as, croscarmellose sodium, sodium starch glycolate and crospovidone) on wetting time, disintegration time, drug content, in vitro release and stability parameters has been studied. Disintegration time and dissolution parameters (t50% and t80%) decreased with increase in the level of croscarmellose sodium. Where as, disintegration time and dissolution parameters increased with increase in the level of sodium starch glycolate in tablets. However, the disintegration time values did not reflect in the dissolution parameter values of crospovidone tablets and release was dependent on the aggregate size in the dissolution medium. Stability studies indicated that tablets containing superdisintegrants were sensitive to high humidity conditions. It is concluded that fast-dispersible aceclofenac tablets could be prepared by direct compression using superdisintegrants.
Somatic mosaicism in ACVRL1 with transmission to several offspring affected with severe pulmonary arterial hypertension

Somatic Mosaicism in ACVRL1 With Transmission to Several Offspring Affected With Severe Pulmonary Arterial Hypertension Gabriela Jones,* Lisa Robertson, Rachel Harrison, Cheryl Ridout, and Pradeep Vasudevan Clinical Genetics Department, University Hospitals Leicester NHS Trust, Leicester, United Kingdom Clinical Genetics Department, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom DNA Laboratory, Guy’s Hospital, London, United Kingdom
Lymph Node Ratio Is an Independent Prognostic Factor in Gastric Cancer After Curative Resection (R0) Regardless of the Examined Number of Lymph Nodes

Objectives: The purpose of this study was to evaluate the outcome of the ratio between metastatic and examined lymph nodes (N ratio) in gastric cancer patients with <15 examined lymph nodes after curative resection. Methods: A retrospective study of 710 patients who underwent radical gastrectomy (R0) for gastric cancer from January 1980 to December 2000 was analyzed statistically to identify the N ratio. Patients with <15 examined lymph nodes (group 1, n=327) and those with ≥15 examined lymph nodes (group 2, n=383) were analyzed separately. N ratio categories were identified as follows: N ratio 0, 0%; N ratio 1, 1% to 9%; N ratio 2, 10% to 25%; and N ratio 3, >25%. All the enrolled categories were evaluated by the best cutoff approach. Results: The univariate analysis showed that age, tumor site, tumor size, surgery, T categories, number of metastatic nodes, and N ratio significantly affected prognosis in groups 1 and 2. By multivariate analysis, the N ratio (but not the TNM N category) classification was retained as an independent prognostic factor in groups 1 and 2 compared with the N category system. However, patients with N1 disease in group 1 obtained a better postoperative prognosis than those with N1 disease in group 2 according to the N stage classification (P=0.003). When the N ratio classification was applied, no significant differences were found for N ratios 0, 1, 2, or 3 between the 2 groups (P>0.05). Conclusions: The metastatic lymph node ratio is an independent prognostic factor regardless of the examined number of lymph nodes. In predicting the prognosis of gastric cancer, the staging system based on the metastatic lymph node ratio is more reliable than the system based on the number of metastatic lymph nodes regardless of the examined number of lymph nodes. This can help improve the TNM staging classification of gastric cancer and reduce the International Union Against Cancer N categories of stage migration.
Congenitally Complete Heart Block

Three cases of congenitally complete heart block are described of hearts in which other minor congenital malformations were not in themselves severe enough to disrupt the atrioventricular conduction system. The cases fitted well into the categorization of complete heart block suggested by Lev. Two exhibited lack of com-munication between the atrial and conducting tissues, the other had discontinuity of the penetrating atrioventricular bundle. In an attempt to explain why this discontinuity between different segments of the conducting tissues occurs, we re-examined several series of graded human embryos. This investigation suggested that the anulus fibrosus in the normal heart is derived from sulcus tissue of the atrioventric-ular junction, the endocardial atrioventricular cushions playing a minor role in the separation of atria from ventricles. The relation-ships between the sulcus tissues and the different components of the atrioventricular junctional area are discussed in terms of an explana-tion both for the existence of different types of congenitally complete heart block and for persistence of Mahaim (nodo-ventricular and nodo-fascicular) fibers.
Relationship Between Aortic Atherosclerosis and Dental Loss in an Inner-City Population

Prior studies have suggested an association between atherosclerosis and periodontal disease, both of which are more prevalent in certain minority and economically disadvantaged groups. Few studies have addressed the relationship between cardiovascular disease and dentition among ethnically diverse populations. We studied 131 subjects (60% females, age 59 ± 15 years) who were referred for clinically indicated transesophageal echocardiography. Dental loss was more severe in patients with hypertension (P < .001), diabetes (P = .05), coronary artery disease (P = .04), and calcium channel blocker use (P = .04). On univariate analysis, maximal aortic intima—media thickness (MAIMT) was significantly correlated with dental loss (r = .40; P < .001). Age was correlated with MAIMT (R = .41; P < .001) and with dental loss (r = .57; P < .001). On multivariate analysis, dental loss (P = .03) and history of coronary artery disease (P = .04) were independent predictors of MAIMT ( R 2 = .44). In this inner-city predominantly African American population, atherosclerosis and dental loss are age dependent and are interrelated independent of age.
Distinguishing Health Benefits of Eicosapentaenoic and Docosahexaenoic Acids

Long chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs) are recommended for management of patients with wide-ranging chronic diseases, including coronary heart disease, rheumatoid arthritis, dementia, and depression. Increased consumption of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) is recommended by many health authorities to prevent (up to 0.5 g/day) or treat chronic disease (1.0 g/day for coronary heart disease; 1.2–4 g/day for elevated triglyceride levels). Recommendations for dietary intake of LC n-3 PUFAs are often provided for α-linolenic acid, and for the combination of EPA and DHA. However, many studies have also reported differential effects of EPA, DHA and their metabolites in the clinic and at the laboratory bench. The aim of this article is to review studies that have identified divergent responses to EPA and DHA, and to explore reasons for these differences. In particular, we review potential contributing factors such as differential membrane incorporation, modulation of gene expression, activation of signaling pathways and metabolite formation. We suggest that there may be future opportunity to refine recommendations for intake of individual LC n-3 PUFAs.
Genomic Instability in Mice Lacking Histone H2AX

Higher order chromatin structure presents a barrier to the recognition and repair of DNA damage. Double-strand breaks (DSBs) induce histone H2AX phosphorylation, which is associated with the recruitment of repair factors to damaged DNA. To help clarify the physiological role of H2AX, we targeted H2AX in mice. Although H2AX is not essential for irradiation-induced cell-cycle checkpoints, H2AX−/− mice were radiation sensitive, growth retarded, and immune deficient, and mutant males were infertile. These pleiotropic phenotypes were associated with chromosomal instability, repair defects, and impaired recruitment of Nbs1, 53bp1, and Brca1, but not Rad51, to irradiation-induced foci. Thus, H2AX is critical for facilitating the assembly of specific DNA-repair complexes on damaged DNA.
Gaussian wiretap channel with a batteryless energy harvesting transmitter

We study the Gaussian wiretap channel with an energy harvesting transmitter which does not have a battery to save energy. In the absence of a battery, the necessary transmission energy is maintained by an i.i. d. energy arrival process. We observe that this channel is an instance of the state-dependent wiretap channel with state available only to the transmitter causally, where the state is the available energy at the transmitter. We prove that the entire capacity-equivocation region can be obtained by single-letter Shannon strategies and its boundary is achieved by input distributions with support set of Lebesgue measure zero.
Anticoagulation in the Elderly

Management of anticoagulation in elderly patients represents a particularly challenging issue. Indeed, this patient population is at high thromboembolic risk, but also at high hemorrhagic risk. Assessment of the benefit-risk balance of anticoagulation is the key point when decisions are made about introducing and/or continuing such treatments in the individual elderly patient. In order to maximise the safety of anticoagulation in the elderly, some specific considerations need to be taken into account, including renal insufficiency, modified pharmacodynamics of anticoagulants, especially vitamin K antagonists, and the presence of multiple comorbidities and concomitant medications. New anticoagulants could greatly simplify and possibly increase the safety of anticoagulation in the elderly in the near future.
Analysis of human papilloma virus in oral squamous cell carcinoma using p16: An immunohistochemical study

Aims: The aim of this study is to evaluate the expression of human papilloma virus (HPV) in oral squamous cell carcinoma (OSCC) and to correlate the association of HPV in histological grades of OSCC using p16 (p16INK4a) immunohistochemistry (IHC). Subjects and Methods: This study consists of 30 histological diagnosed cases of OSCC (10-well-differentiated oral squamous cell carcinoma [WDOSCC], 10-moderately differentiated oral squamous cell carcinoma [MDOSCC] and 10-poorly differentiated oral squamous cell carcinoma [PDOSCC]). The sections were subjected to IHC procedure using p16. Two parameters in immunohistochemical p16 expression were evaluated by 3 observers based on the criteria by Galgano M. Tetal (2010) (a) percentage of p16 positive cases (b) pattern of p16 staining in various grades of OSCC. Statistical Analysis Used: Kappa test. Results: Totally, 30 samples of 0SCC, p16 positivity was noted in 26/30 (86.66%). Of 26 positive cases, p16 staining was positive in 7/10 (70%) of WDOSCC, 9/10 (90%) in MDOSCC and, 10/10 (100%) PDOSCC. Incidentally, we also found single dispersed cell staining in WDOSCC, patchy staining in MDOSCC and more diffuse staining pattern predominant in PDOSCC. Conclusions: Our study revealed an association between HPV and OSCC. Diffuse staining pattern was noted in PDOSCC, which in turn depicts the increase viral overload, which might have an influence on its aggressive behavior.
Is there a reduction of congenital abnormalities in the offspring of diabetic pregnant women after folic acid supplementation? A population‐based case‐control study

The objective of the present study was to estimate the preventive effect of folic acid for structural birth defects (i.e. congenital abnormalities [CAs]) in the offspring of pregnant women with diabetes mellitus type 1 (DM‐1). The occurrence of medically recorded DM‐1 in pregnant women who had malformed fetuses/newborns (cases) and delivered healthy babies (controls) with or without folic acid supplementation was compared in the population‐based Hungarian Case‐Control Surveillance System of Congenital Abnormalities. The case group included 22 843 offspring, and there were 79 (0.35%) pregnant women with DM‐1, while the control group comprised of 38 151 newborns, and 88 (0.23%) had mothers with DM‐1. Case mothers with DM‐1 associated with a higher risk of total rate of CAs in their offspring (OR with 95% CI: 1.5, 1.1–2.0) compared to the total rate of CAs in the offspring of non‐diabetic case mothers. This higher risk can be explained by four specific types/groups of CAs: isolated renal a/dysgenesis; obstructive CA of the urinary tract; cardiovascular CAs; and multiple CAs, namely caudal dysplasia sequence. However, there was no higher rate of total CAs in the children of pregnant women with DM‐1 after folic acid supplementation; in addition, neural‐tube defect and renal a/dysgenesis did not occur. However, this benefit cannot be explained by the CA reduction effect of folic acid during the critical period of major CAs. In conclusion, there was a certain reduction in maternal teratogenic effect of DM‐1 after folic acid supplementation during pregnancy, but the explanation of this effect requires further study.
Viewpoint Centric Design

System engineering often states that respecting diversity during the upstream stages of a system designing is an unavoidable feature of the designing process. In the field of Information Systems, the ability to evolve is a pivotal quality of its computer aided components. A framework is presented to view an Information System as a designing place where viewpoints interact with each other on objects to be designed. Each actor of the Information system is the stakeholder of a particular viewpoint on the Information System. He or she triggers activities which are cooperating processes. Viewpoints are traces of these processes.
Nano-RK: an energy-aware resource-centric RTOS for sensor networks

Many sensor networking applications such as surveillance and environmental monitoring are time-sensitive in nature. To support such applications, we design and implement Nano-RK, a reservation-based real-time operating system (RTOS) with multi-hop networking support for use in wireless sensor networks. We support fixed-priority preemptive multitasking for guaranteeing that task deadlines are met, along with support for CPU and network bandwidth reservations. Tasks can specify their resource demands and the operating system provides timely, guaranteed and controlled access to CPU cycles and network packets in resource-constrained embedded sensor environments. We also introduce the concept of virtual energy reservations that allows the OS to enforce energy budgets associated with a sensing task by controlling resource accesses. A lightweight wireless networking stack supports packet forwarding, routing and TDMA-based network scheduling. Nano-RK has been implemented on the Atmel ATMEGA128 processor with the Chipcon CC2420 802.15. 4 transceiver chip. Our results show that a light-weight embedded resource kernel with rich functionality and timing support is practical and constitutes a simple and alternative paradigm for supporting distributed sensing tasks
Color selectivity of neurons in the inferior temporal cortex of the awake macaque monkey

We tested the color selectivity of neurons in the inferior temporal (IT) cortex of two awake macaque monkeys. A color stimulus was presented at the center of the visual field while the animal performed a fixation task. The responses of single units to various colors were recorded and were plotted in a color space. The color space was based on the CIE (Commission Internationale de l'Eclairage) chromaticity diagram. Quantitative analysis of the color selectivity was performed using a standard set of colors that were evenly distributed in the color space. Sixty-five neurons recorded from eight guide tubes implanted in anterior part of IT cortex were tested quantitatively, and their color selectivity was statistically evaluated. Forty-six of them (71%) were classified as color selective. Color-selective cells responded to some colors but not to others, and we called the responsive region in the color space the “color field. ” The location and the size of a cell's color field were largely independent of the luminance of the stimulus. About 80% of the color-selective neurons had color fields consisting of a single responsive region that were restricted in some part of the color space, and the remaining cells had more than one responsive region within the color space. Preferred hues of the color-selective neurons differed from cell to cell. The population of cells together covered nearly all of the color space. There was a tendency for more color-selective cells to be less sensitive to white and desaturated cyans. Some of the cells with color fields that consisted of more than one responsive region were more sensitive to saturation of the stimulus than to its hue. Although previous electrophysiological studies in IT cortex emphasized the pattern selectivity of the neurons, our results suggest that color is an important factor in the role that IT cortex plays in the object recognition.
Fitness attenuates the prevalence of increased coronary artery calcium in individuals with metabolic syndrome

Background The association between cardiorespiratory fitness, physical activity and coronary artery calcium (CAC) is unclear, and whether higher levels of fitness attenuate CAC prevalence in subjects with metabolic syndrome is not fully elucidated. The present study aims to: a) investigate the independent association of fitness on the prevalence of CAC, after adjustment for moderate-to-vigorous physical activity and sedentary time, and b) study the possible attenuation of increased CAC by higher fitness, in participants with metabolic syndrome. Design Cross-sectional. Methods In total 678 participants (52% women), 50–65 years old, from the SCAPIS pilot study were included. Fitness (VO2max) was estimated by submaximal cycle ergometer test and moderate-to-vigorous physical activity and sedentary time were assessed using hip-worn accelerometers. CAC score (CACS) was quantified using the Agatston score. Results The odds of having a significant CACS (≥100) was half in participants with moderate/high fitness compared with their low fitness counterparts. Further consideration of moderate-to-vigorous physical activity, sedentary time and number of components of the metabolic syndrome did only slightly alter the effect size. Those with metabolic syndrome had 47% higher odds for significant CAC compared with those without metabolic syndrome. However, moderate/high fitness seems to partially attenuate this risk, as further joint analysis indicated an increased odds for having significant CAC only in the unfit metabolic syndrome participants. Conclusions Being fit is associated with a reduced risk of having significant CAC in individuals with metabolic syndrome. While still very much underutilized, fitness should be taken into consideration in everyday clinical risk prediction in addition to the traditional risk factors of the metabolic syndrome.
Macro-micro tele-manipulation system based on body image embedding with contact feel, spatial motion and stereo vision

In this paper, we propose a novel macro-micro tele-manipulation system based on body image embedding with contact feel, spatial motion and stereo vision for micro-manipulation under a microscope. The basic concept of body image embedding for macro-micro tele-manipulation has been already proposed by the authors. The system proposed here has three new realization ideas. The first idea is the realization of realistic contact feeling which is attained by driving a voice coil motor according to the binary on/off information of the switch between micro-tools. The use of a voice coil motor not only saves the cost of the system, but also generates clearer tactile and auditory stimuli than a piezo actuator for sending contact information in a micro world to an operator. The switch between micro-tools does not detect the contact between the object to be manipulated and the tool for manipulation directly, but can be useful for some tasks. The second idea is the realization of spatial motion of the manipulation tool relative to the object to be manipulated, which is realized by the appropriate coordination of the 2-degree-of-freedom motions of the slave manipulators. The third idea is the realization of stereo vision under the constraint of the position/orientation consistency of an operator's body image between proprioception and vision, which is achieved by the special placement of the dual joysticks of the dual micro-manipulators. The effectiveness of the proposed realization method is verified experimentally by micro-drawing tasks where we need appropriate hybrid position/force control of the micro-tool for manipulation in a three-dimensional space.