Miracle-dz/UniFAR-FTUs huggingface dataset:
Renal Structure in Normoalbuminuric and Albuminuric Patients With Type 2 Diabetes and Impaired Renal Function

OBJECTIVE The structural basis of normoalbuminuric renal insufficiency in patients with type 2 diabetes remains to be elucidated. We compared renal biopsy findings in patients with type 2 diabetes and estimated glomerular filtration rate (eGFR) and measured GFR of <60 mL/min/1.73 m2, associated with either normo-, micro-, or macroalbuminuria. RESEARCH DESIGN AND METHODS In patients with normo- (n = 8) or microalbuminuria (n = 6), renal biopsies were performed according to a research protocol. In patients with macroalbuminuria (n = 17), biopsies were performed according to clinical indication. Findings were categorized according to the Fioretto classification: category 1 (C1), normal/near normal; category 2 (C2), typical diabetic nephropathy (DN) with predominantly glomerular changes; and category 3 (C3), atypical with disproportionately severe interstitial/tubular/vascular damage and with no/mild diabetic glomerular changes. RESULTS In our study population (mean eGFR 35 mL/min/1.73 m2), typical glomerular changes (C2) of DN were observed in 22 of 23 subjects with micro- or macroalbuminuria compared with 3 of 8 subjects with normoalbuminuria (P = 0.002). By contrast, predominantly interstitial or vascular changes (C3) were seen in only 1 of 23 subjects with micro- or macroalbuminuria compared with 3 of 8 normoalbuminuric subjects (P = 0.08). Mesangial area increased progressively from normal controls to patients with type 2 diabetes and normo-, micro-, and macroalbuminuria. Varying degrees of arteriosclerosis, although not necessarily the predominant pattern, were seen in seven of eight subjects with normoalbuminuria. CONCLUSIONS Typical renal structural changes of DN were observed in patients with type 2 diabetes and elevated albuminuria. By contrast, in normoalbuminuric renal insufficiency, these changes were seen less frequently, likely reflecting greater contributions from aging, hypertension, and arteriosclerosis.
Using Application Data for SLA-Aware Auto-scaling in Cloud Environments

With the establishment of cloud computing as the environment of choice for most modern applications, auto-scaling is an economic matter of great importance. For applications like stream computing that process ever changing amounts of data, modifying the number and configuration of resources to meet performance requirements becomes essential. Current solutions on auto-scaling are mostly rule-based using infrastructure level metrics such as CPU/memory/network utilization, and system level metrics such as throughput and response time. In this paper, we introduce a study on how effective auto-scaling can be using data generated by the application itself. To make this assessment, two algorithms are proposed that use a priori knowledge of the data stream and use sentiment analysis from soccer-related tweets, triggering auto-scaling operations according to rapid changes in the public sentiment about the soccer players that happens just before big bursts of messages. Our application-based auto-scaling was able to reduce the number of SLA violations by up to 95% and reduce resource requirements by up to 33%.
A DRM based on renewable broadcast encryption

We propose an architecture for digital rights management based on a renewable, random key pre-distribution (KPD) scheme, HARPS (hashed random preloaded subsets). The proposed architecture caters for broadcast encryption by a trusted authority (TA) and by "parent" devices (devices used by vendors who manufacture compliant devices) for periodic revocation of devices. The KPD also facilitates broadcast encryption by peer devices, which permits peers to distribute content, and efficiently control access to the content encryption secret using subscription secrets. The underlying KPD also caters for broadcast authentication and mutual authentication of any two devices, irrespective of the vendors manufacturing the device, and thus provides a comprehensive solution for securing interactions between devices taking part in a DRM system.
Location Estimation in Indoor Environments Using Multiple Items of Sensed Information

Receiving radio waves directly from satellites is difficult in an indoor environment, making accurate location estimation by satellite signals difficult. Since mobile communication propagation channels suffer from fading and shadowing, estimating accurate locations in an indoor environment by using only the received signal power of a radio wave is also difficult. Items of sensed information, e.g., temperature, humidity, and illuminance, are frequently location dependent, and location estimation can be more accurate if such information is used in addition to received signal power. We proposed a minimum mean square error (MMSE) estimation method for indoor location estimation using multiple items of sensed information. Machine learning has recently become attractive as an optimization algorithm; thus, we also proposed applying machine learning with a back-propagation method. We experimentally evaluated our location-estimation methods.
Mitochondrial iron-sulfur cluster dysfunction in neurodegenerative disease

Growing evidence supports a role for mitochondrial iron metabolism in the pathophysiology of neurodegenerative disorders such as Friedreich ataxia (FRDA) and Parkinson disease (PD) as well as in the motor and cognitive decline associated with the aging process. Iron–sulfur enzyme deficits and regional iron accumulation have been observed in each of these conditions. In spite of significant etiological, clinical and pathological differences that exist between FRDA and PD, it is possible that defects in mitochondrial iron–sulfur clusters (ISCs) biogenesis represent a common underlying mechanism leading to abnormal intracellular iron distribution with mitochondrial iron accumulation, oxidative phosphorylation deficits and oxidative stress in susceptible cells and specific regions of the nervous system. Moreover, a similar mechanism may contribute to the age-dependent iron accumulation that occurs in certain brain regions such as the globus pallidus and the substantia nigra. Targeting chelatable iron and reactive oxygen species appear as possible therapeutic options for FRDA and PD, and possibly other age-related neurodegenerative conditions. However, new technology to interrogate ISC synthesis in humans is needed to (i) assess how defects in this pathway contribute to the natural history of neurodegenerative disorders and (ii) develop treatments to correct those defects early in the disease process, before they cause irreversible neuronal cell damage.
Visual Function of Egyptian Children with Low Vision and the Demographic Determinants

Aims: To determine whether the LV Prasad-Functional Vision Questionnaire (LVP-FVQ) could be used to assess self-reported visual function and quality of visual life in Egyptian school aged children. Materials and Methods: The LVP-FVQ was used to assess the quality of visual function in school-age children. All subjects were students at the time of assessment. Subjects underwent a visual function assessment that included distance and near visual acuity, contrast sensitivity, color vision and visual field examination where possible. Data analysis were for both descriptive and inference statistics. A P < 0.05 was considered statistically significant. Results: Fifty children aged 11.28 ± 3.5 years (range, 5 years to 18 years) with moderate-to-severe visual impairment most of their lives were enrolled. Twenty-two subjects (44%) had albinism, 18 (36%) subjects had hereditary retinal dystrophy, 6 (12%) subjects had cone dystrophy, 2 (4%) subjects had bilateral amblyopia and 2 (4%) subjects had congenital coloboma without other disabilities. The four most difficult tasks were related to the following daily activities alluded to in the questionnaire such as reading a textbook at arms length, copying from the blackboard, seeing somebody across the road and identifying colors. There was no statistically significant association between the demographic variables and the level of visual functioning, sex, age, type of school, family history or consanguinity (P > 0.05 for all variables). Conclusion: LVP-FVQ can be used to screen Egyptian children with visual impairment. Input and integration of the parents and the school teachers to evaluate the child s behavior at home and the school is essential to developing a balanced questionnaire.
The Evolution and Devolution of 360° Feedback

In the 25+ years that the practice of 360° Feedback has been formally labeled and implemented, it has undergone many changes. Some of these have been positive (evolution) in advancing theory, research, and practice, and others less so (devolution). In this article we offer a new definition of 360° Feedback, summarize its history, discuss significant research and practice trends, and offer suggestions for all user communities (i.e., researchers, practitioners, and end users in organizations) moving forward. Our purpose is to bring new structure, discussion, and some degree of closure to key open issues in this important and enduring area of practice.
Direct and indirect responses to metabotropic glutamate receptor activation in the brain.

Introduction Glutamate is the most important excitatory transmitter substance in the central nervous system and, as is generally the case for information-carrying biomolecules, extends its range by having multiple recognition sites coupled to different post-receptor signalling systems. The receptors for glutamate can be divided broadly into ionotropics, which are coupled to ion channels and mediate fast (ms time-scale) responses (N-methyl-l)-aspartate, a-amino-3-hydroxyl-Sniethylisoxazole-4-propionic acid, kainate receptors), and the more recently identified metabotropic receptors (mCluRs), which are part of the G-protein-linked superfamily. This latter group is responsible for the slower effects brought about by the regulation of intracellular second messenger levels. The mGluRs are made up of a family of five receptors (mGluR, -5) plus alternatively spliced variants, that have been cloned, sequenced and expressed in model cell systems, and a sixth that has yet to be fully characterized [ 11. They appear to have the expected seven transmembrane-spanning regions characteristic of G-protein-coupled receptors, but are unusual in being very large (mGluR, has 1199 amino acids) and in having long hydrophilic tails both on the Nand on the C-terminal sides of the transmembrane region. They show little or no sequence similarity with other G-proteinlinked receptors. It should come as no surprise that the mGluRs couple to a variety of second-messengergenerating systems, but here a plea for caution should be made since many of the studies concerned with mGluR function have employed model cells transfected with the different mCluRs. There is now compelling evidence from studies of a number of receptor systems that, given sufficient receptor
Childhood and Violence in Advertising

This article considers the subject of childhood and violence contained in the advertising format, focusing especially on television advertising. The article analyses the violent and aggressive content of audiovisual texts looking at childhood from a broader perspective than has been used in research to date, in order to show the wide spectrum of involvement of children in advertising material. This new focus implies looking at the subject of childhood and media violence in televised advertising taking into account the strategic communicative process, in which regard the figure of the child can be studied from three different yet complementary lines of analysis. The first evolves around the child as advertising target, according to the campaign's objective and the intention of the advertiser or issuer of the advertising message. The second line of analysis refers to the use of children as advertising resources, which can provoke effects at a cognitive, affective or even behavioural level. Third and finally, one can refer to children as receptors of advertising, an aspect associated with the behaviour and habits of television and advertising intake by these young viewers. The importance and current relevance of the subject are highlighted in the legislative interventions of national governments as well as transnational institutions (for example the EU) that are related to violence in advertising and childhood.
A DJ-1 Based Peptide Attenuates Dopaminergic Degeneration in Mice Models of Parkinson's Disease via Enhancing Nrf2

Drugs currently used for treating Parkinson's disease patients provide symptomatic relief without altering the neurodegenerative process. Our aim was to examine the possibility of using DJ-1 (PARK7), as a novel therapeutic target for Parkinson's disease. We designed a short peptide, named ND-13. This peptide consists of a 13 amino acids segment of the DJ-1-protein attached to 7 amino acids derived from TAT, a cell penetrating protein. We examined the effects of ND-13 using in vitro and in vivo experimental models of Parkinson's disease. We demonstrated that ND-13 protects cultured cells against oxidative and neurotoxic insults, reduced reactive oxygen species accumulation, activated the protective erythroid-2 related factor 2 system and increased cell survival. ND-13 robustly attenuated dopaminergic system dysfunction and in improved the behavioral outcome in the 6-hydroxydopamine mouse model of Parkinson's disease, both in wild type and in DJ-1 knockout mice. Moreover, ND-13 restored dopamine content in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model. These findings validate DJ-1 as a promising therapeutic target in Parkinson's disease and identify a novel peptide with clinical potential, which may be significant for a broader range of neurological diseases, possibly with an important impact for the neurosciences.
An untethered self-folding locomotive paper robot using pneumatic actuators

This paper proposes an untethered self-folding locomotive paper robot. Its self-folding locomotion is similar to the opening and folding of the Chinese hand-held fan. We achieve this fan-like self-folding motion by the special design of paper cases and utilization of a novel 3D sticky pneumatic actuator. The actuator is a bladder with adhesive backs. Its inflation and contraction are controlled by two miniature pumps respectively. The opening and folding motions of the robot are synchronized with the inflation and contraction of the actuator. The electronics are clock-based controlled by an Arduino board. Instead of relying on the friction force, the robot utilizes the moment produced by the gravitational force to achieve locomotion. Thus, the robot is able to operate on surfaces where the friction coefficients are small. The average speed of its locomotion is 0.825cm/s. The robot features low cost, accessibility and instant-fabrication. The materials and equipment used for fabrications are paper cardboards, plastic membrane, tapes, tubes, scissors, miniature pumps, batteries, relays, solenoid valves, and Arduino boards which are all widely used in and easily obtained from daily life.
Dup(1q)(q42-->qter) syndrome: case report and review of literature.

We report on a patient with primordial growth retardation, mental retardation, and minor anomalies (triangular face, open sagittal suture, frontal bossing, telecanthus, upturned nose, micrognathia, and small mouth with downturned corners). The diagnosis of Russell-Silver syndrome (RSS) had been considered but was abandoned when cytogenetic evaluation showed a partial trisomy 1q or duplication 1q (46,XY,15, + der(15)t(1;15)(q42;qter). Data from another 5 reports of dup(1)(q42-->qter) do not allow delineation of a typical syndrome. However, individuals with dup(1q), del(15q), and Russell-Silver syndrome share common manifestations (i.e., low birth weight, growth retardation, triangular face, low set/abnormal ears, micrognathia, renal anomalies.
Arterial Response to Shear Stress Critically Depends on Endothelial TRPV4 Expression

Background In blood vessels, the endothelium is a crucial signal transduction interface in control of vascular tone and blood pressure to ensure energy and oxygen supply according to the organs' needs. In response to vasoactive factors and to shear stress elicited by blood flow, the endothelium secretes vasodilating or vasocontracting autacoids, which adjust the contractile state of the smooth muscle. In endothelial sensing of shear stress, the osmo- and mechanosensitive Ca2+-permeable TRPV4 channel has been proposed to be candidate mechanosensor. Using TRPV4−/− mice, we now investigated whether the absence of endothelial TRPV4 alters shear-stress-induced arterial vasodilation. Methodology/Principal Findings In TRPV4−/− mice, loss of the TRPV4 protein was confirmed by Western blot, immunohistochemistry and by in situ-patch–clamp techniques in carotid artery endothelial cells (CAEC). Endothelium-dependent vasodilation was determined by pressure myography in carotid arteries (CA) from TRPV4−/− mice and wild-type littermates (WT). In WT CAEC, TRPV4 currents could be elicited by TRPV4 activators 4α-phorbol-12,13-didecanoate (4αPDD), arachidonic acid (AA), and by hypotonic cell swelling (HTS). In striking contrast, in TRPV4−/− mice, 4αPDD did not produce currents and currents elicited by AA and HTS were significantly reduced. 4αPDD caused a robust and endothelium-dependent vasodilation in WT mice, again conspicuously absent in TRPV4−/− mice. Shear stress-induced vasodilation could readily be evoked in WT, but was completely eliminated in TRPV4−/− mice. In addition, flow/reperfusion-induced vasodilation was significantly reduced in TRPV4−/− vs. WT mice. Vasodilation in response to acetylcholine, vasoconstriction in response to phenylephrine, and passive mechanical compliance did not differ between genotypes, greatly underscoring the specificity of the above trpv4-dependent phenotype for physiologically relevant shear stress. Conclusions/Significance Genetically encoded loss-of-function of trpv4 results in a loss of shear stress-induced vasodilation, a response pattern critically dependent on endothelial TRPV4 expression. Thus, Ca2+-influx through endothelial TRPV4 channels is a molecular mechanism contributing significantly to endothelial mechanotransduction.
The sleep of (criminological) reason: Knowledge—policy rupture and New Labour’s youth justice legacy

For over a decade, three successive New Labour administrations have subjected the English youth justice system to a seemingly endless sequence of reforms. At the root of such activity lies a core tension between measured reason and punitive emotion; between an expressed commitment to ‘evidence-based policy’ and a populist rhetoric of ‘tough’ correctionalism. By engaging a detailed analytical assessment of New Labour’s youth justice programme, this article advances an argument that the trajectory of policy has ultimately moved in a diametrically opposed direction to the route signalled by research-based knowledge and practice-based evidence. Moreover, such knowledge— policy rupture has produced a youth justice system that ultimately comprises a conduit of social harm. All of this raises serious questions of knowledge/evidence—policy relations and, more fundamentally, of democracy, power and accountability.
PELAYANAN DAN PERSEPSI MASYARAKAT TERHADAP JAMKESMAS (STUDI KASUS DI PUSKESMAS II BATURADEN, KABUPATEN BANYUMAS)

Humans which are physically and mentally health is a valuable asset to the country's resources . Therefore, a healthy human being is an investment in the state. State is obliged to maintain the health of its citizens, and citizens are entitled to health assuredness. To ensure people's access to health services, since 1998 the Government has implemented a range of health maintenance effort, one of them was through the Community Health Insurance Program. Since the commencement of the program, theres a news about the general phenomenon related to the participants of JAMKESNAS public service, such as a convoluted rules, the behavior of individual officers who sometimes unfriendly in serving the public, and also minimum performance of employees in providing services. This study was conducted to determine how the JAMKESMAS services, and how the public perception about the service. This study was conducted in 2012 in PHC II Baturaden, Banyumas, Purwokerto, Central Java. The study was conducted using qualitative methods. Results showed that although the complaint is found in such things as: doctors who lack empathy unwillingly listen to patient complaints, and less attention, but public services in health centers II Baturaden generally received good appreciation from the public. This is partly due to the program in addition to this JAMKESNAS really do without the levy, also a paramedic background according to their competence, health centers and business managerial competence. Manusia yang secara fisik dan mental sehat merupakan aset berharga bagi sumber daya negara. Oleh karena itu, manusia yang sehat merupakan investasi negara. Negara berkewajiban untuk menjaga kesehatan warganya, dan warga berhak atas keyakinan kesehatan. Untuk menjamin akses masyarakat terhadap pelayanan kesehatan. Sejak tahun 1998 Pemerintah telah melaksanakan berbagai upaya pemeliharaan kesehatan, salah satunya adalah melalui Program Jaminan Kesehatan Masyarakat. Sejak dimulainya program ini, ada berita tentang fenomena umum yang berkaitan dengan peserta dari pelayanan publik Jamkesmas, seperti aturan berbelit-belit, perilaku petugas perorangan yang kadang-kadang tidak ramah dalam melayani masyarakat, dan juga kinerja minimum karyawan dalam memberikan layanan. Penelitian ini dilakukan untuk mengetahui bagaimana layanan Jamkesmas, dan bagaimana persepsi masyarakat tentang layanan. Penelitian ini dilakukan pada tahun 2012 di Puskesmas II Baturaden, Banyumas, Purwokerto, Jawa Tengah. Penelitian dilakukan dengan menggunakan metode kualitatif. Hasil penelitian menunjukkan bahwa meskipun keluhan ditemukan dalam hal-hal seperti: dokter yang tidak memiliki empati enggan mendengarkan keluhan pasien, dan kurang perhatian, tetapi pelayanan publik di Puskesmas II Baturaden umumnya mendapat apresiasi yang baik dari masyarakat. Hal ini sebagian karena program ini selain Jamkesmas ini benar-benar tanpa pungutan, juga latar belakang paramedis sesuai dengan kompetensi, pusat-pusat kesehatan dan kompetensi manajerial bisnis.
Género y nivel educativo en las narrativas autobiográficas de la infancia

The present work deals with autobiographic memory, educative background and gender roles. It is based in socio–cultural psychology research supporting the relationship between context and the development of cognitive processes. 96 structured interviews were made in Cd. Victoria, Tamaulipas to men and women with different educative background: literacy, basic education and university, they ranged between 30 and 55 years old. Personal recollections analysis is based in the categories proposed by Wang (Wang 2001, Wang y Conway 2004). Roles of main characters present in the autobiographical narratives were also investigated using family, educational, work, recreational, and sport contexts. The results shows that women childhood narratives centered in social themes, it has more emotional expresions and the roles are related to child care, domestic work and the enjoyment of school work. Men narratives content is about their own wishes and interests, it has less emotional verbal expressions, they are prone to help with child care but not with domestic work, besides, they show a bigger interest in sports. It was also found that the greater the educative background, the larger the narrative production.