Miracle-dz/UniFAR-FTUs huggingface dataset:
Optical Coherence Tomography-Guided versus Angiography-Guided PCI.

BACKGROUND Data regarding clinical outcomes after optical coherence tomography (OCT)-guided percutaneous coronary intervention (PCI) as compared with angiography-guided PCI are limited. METHODS In this prospective, randomized, single-blind trial, we randomly assigned patients with medication-treated diabetes or complex coronary-artery lesions to undergo OCT-guided PCI or angiography-guided PCI. A final blinded OCT procedure was performed in patients in the angiography group. The two primary efficacy end points were the minimum stent area after PCI as assessed with OCT and target-vessel failure at 2 years, defined as a composite of death from cardiac causes, target-vessel myocardial infarction, or ischemia-driven target-vessel revascularization. Safety was also assessed. RESULTS The trial was conducted at 80 sites in 18 countries. A total of 2487 patients underwent randomization: 1233 patients were assigned to undergo OCT-guided PCI, and 1254 to undergo angiography-guided PCI. The minimum stent area after PCI was 5.72±2.04 mm2 in the OCT group and 5.36±1.87 mm2 in the angiography group (mean difference, 0.36 mm2; 95% confidence interval [CI], 0.21 to 0.51; P<0.001). Target-vessel failure within 2 years occurred in 88 patients in the OCT group and in 99 patients in the angiography group (Kaplan-Meier estimates, 7.4% and 8.2%, respectively; hazard ratio, 0.90; 95% CI, 0.67 to 1.19; P = 0.45). OCT-related adverse events occurred in 1 patient in the OCT group and in 2 patients in the angiography group. Stent thrombosis within 2 years occurred in 6 patients (0.5%) in the OCT group and in 17 patients (1.4%) in the angiography group. CONCLUSIONS Among patients undergoing PCI, OCT guidance resulted in a larger minimum stent area than angiography guidance, but there was no apparent between-group difference in the percentage of patients with target-vessel failure at 2 years. (Funded by Abbott; ILUMIEN IV: OPTIMAL PCI ClinicalTrials.gov number, NCT03507777.).
Influence of agroecological factors on winter oilseed rape (Brassica napus L.) autumn growth.

sowing area under oil-seed rape (Brassica napus L.) has increased during last decade in Latvia and has become more or less stable since 2007. Lack of research on impact of sowing date, sowing rate, fungicide as growth regulator application and other agroecological factor issues on rape autumn growth is observed. the aim of our research, started in autumn 2007 in research and study farm ‘vecauce’, was to investigate the influence of applied agroecological factors (five sowing dates, four sowing rates and fungicide (as growth regulator in autumn) application on two type winter rape varieties development in autumn. Winter rape biometrical parameters, dry matter content and dry mass per m2 of leaves were estimated. sowing date affected height of growth point, root neck diameter, plant and root mass, main root length significantly (p<0.05). sowing rate affected only some indices significantly in autumn 2007. fungicide (juventus 90 s.c. metconasol 90 g L-1) application also affected rape plant biometric parameters during autumn depending on conditions of research year – height of growth point decreased only in year 2007, effect on number of leaves per plant was observed in both trial years, plant weight (2007) and root length (2008) were affected for hybrid variety. sowing date showed effect on dry matter content in leaves as well as on dry matter mass of leaves per 1 m2. fungicide application increased dry mass of leaves per 1 m2 in two earlier sowing dates. results are important also for outline of further research directions evaluating significance of above mentioned factors for winter rape wintering in Latvia.
Predictors of suicidal behaviour within South Asian females

Suicide is seen to be the second leading cause of death worldwide, and the South Asians are seen to be a very high risk group due to the traditional cultural values they hold. The South Asian culture can be seen as a facilitator in suicidal behaviour due to its rigidly defined cultural values. The most dominant theory of suicide seem to be the interpersonal theory of suicide first proposed by Joiner (2005). The theory however can be seen to be limited as it does not take into account cultural factors which may affect its core structures. The present study thus looked at how South Asian cultural values would influence the Interpersonal Theory of Suicide. 215 South Asian females took part in a questionnaire to measure their suicidal behaviours and the proposed predictors of suicide. A logistic binary regression found that the significant predictors of suicide that made participants more likely to consider suicide within the last 12 months were a higher perceived burdensomeness, lower social support from friends and a higher association to South Asian cultural values. None of the variables were seen to significantly predict suicide attempts within the last 12 months. Results thus showed that South Asian cultural values do in fact have an influence on the Theory of Interpersonal Suicide as South Asian women could be more at risk for suicidal ideation. The present study thus supports research that culturally sensitive psychological interventions need to be put in place to help South Asian women who could be more at risk for suicidal behaviour, to seek help and treatment.
Vision-based path planning, collision avoidance, and target tracking for unmanned air and ground vehicles in urban environments

Unmanned vehicle systems, specifically Unmanned Air Vehicles (UAVs) and Unmanned Ground Vehicles (UGVs) have found potential use in both military and civilian applications. For many applications, unmanned vehicle systems are required to navigate in urban environments where obstacles with various types and sizes exist. The main contribution of this research is to offer vision-based path planning, collision avoidance, and target tracking strategies for Unmanned Air and Ground vehicles operating in urban environments. Two vision-based local-level frame mapping and planning techniques are first developed for Miniature Air Vehicles (MAVs). The techniques build maps and plan paths in the local-level frame of MAVs directly using the camera measurements without transforming to the inertial frame. Using a depth map of an environment obtained by computer vision methods, the first technique employs an extended Kalman Filter (EKF) to estimate the range, azimuth to, and height of obstacles, and constructs local spherical maps around MAVs. Based on the maps, the Rapidly-Exploring Random Tree (RRT) algorithm is used to plan collision-free Dubins paths. The second technique constructs local multi-resolution maps using an occupancy grid, which give higher resolution to the areas that are close to MAVs and give lower resolution to the areas that are far away. The maps are built using a log-polar representation. The two planning techniques are demonstrated in simulation and flight tests. Based on the observation that a camera does not provide accurate time-to-collision (TTC) measurements, two and three dimensional observability-based planning algorithms are explored. The techniques estimate both TTC and bearing using bearing-only measurements. A nonlinear observability analysis of state estimation process is conducted to obtain the conditions for complete observability of the system. Using the conditions, the observability-based planning algorithms are designed to minimize the estimation uncertainties while simultaneously avoiding collisions. The two dimensional planning algorithm parameterizes an obstacle using TTC and azimuth, and constructs local polar maps. The three dimensional planning algorithm parameterizes an obstacle using inverse TTC, azimuth, and elevation, and constructs local spherical maps. The algorithms are demonstrated in simulation. Lastly, a probabilistic path planning algorithm is developed for tracking a moving target in urban environments using UAVs and UGVs. The algorithm takes into account occlusions due to obstacles. It models the target using a dynamic occupancy grid and updates the target location using a Bayesian filter. Based on the target's current and probable future locations, a decentralized path planning algorithm is designed to generate suboptimal paths that maximize the sum of the joint probability of detection for all vehicles over a finite look-ahead horizon. Results demonstrate the planning algorithm is successful in solving the moving target tracking problem in urban environments.
Supplement 3

Significant relationships and illustrations of the shapes of the size distributions of ORFS described by the non-random distribution of the exponential-log normal mixture model and annotated proteins. All parameter values are listed in Supplement 1. Within this supplement, figure one depicts the statistical relationships between the parameters estimated with the exponential-log normal model and parameters estimated from annotated proteins (also see figure 4 in main document), and figures two through 312 illustrate the shapes of each of these distributions (arranged alphabetically by species to correspond with Supplement 1). In these figures red lines represent the shapes of the distributions estimated from the mixture model and blue lines show the shape of the distribution from the annotated proteins. It is important to note from these figures that the shapes of the size distributions of non-random ORFs deviate from the annotated proteins such that the number of small non-random ORFs is consistently greater than the number of small annotated proteins. Consequently, the means of the lognormal distributions estimated from the mixture models are smaller and the peaks of the distributions shifted to the left of those for annotated proteins. Moreover, the magnitude of the shift is greater in multicellular eukaryotes than prokaryotes. Nevertheless, the mean and standard deviation estimated from the mixture model fits are significantly correlated with the parameter estimates from fits to annotated proteins (S4 – Fig. 1).
Advance Publication Experimental Animals

The metastasis of various cancers is promoted by hyperglycemia. In contrast, melanoma and colorectal cancer seemed to be exceptional. We confirmed that the metastasis of melanoma B16-F10 could be suppressed by hyperglycemia. It was attractive from the prognostic point of view of the prevention of metastasis, though the problem of the risk of diabetes remained. Then, the effect of moderate hyperglycemic condition was investigated using a pre-diabetic model mouse (GKKO mouse). The metastasis of B16-F10 cells to liver was focused and the number and volume of metastatic colonies in liver were analyzed. The medians of the number of metastatic colonies in GKKO mice were 0.57-fold (p=0.06) compared to control mice. Analysis of macrophage markers revealed upregulation of CD86 , a tumor-suppressive M1-type marker, and downregulation of CD206 , a tumor-promotive M2-type marker. A tendency of upregulation of Cxcl10 , a pro-inflammatory cytokine was also observed. Regarding cellular activities of B16-F10, migration activity and invasion activity were reduced by moderate hyperglycemia. In conclusion, metastasis of B16-F10 cells to liver could be suppressed by moderate hyperglycemia without the risk of diabetes. This information should contribute to dietary planning during prognosis.
Assessing diversity in the Camelina genus provides insights into the genome structure of Camelina sativa

Camelina sativa (L.) Crantz an oilseed crop of the Brassicaceae family is gaining attention due to 27 its potential as a source of high value oil for food, feed or fuel. The hexaploid domesticated C. 28 sativa has limited genetic diversity, encouraging the exploration of related species for novel 29 allelic variation for traits of interest. The current study utilised genotyping by sequencing to 30 characterise 193 Camelina accessions belonging to seven different species collected primarily 31 from the Ukrainian-Russian region and Eastern Europe. Population analyses among Camelina 32 accessions with a 2n = 40 karyotype identified three subpopulations, two composed of 33 domesticated C. sativa and one of C. microcarpa species. Winter type Camelina lines were 34 identified as admixtures of C. sativa and C. microcarpa. Eighteen genotypes of related C. 35 microcarpa unexpectedly shared only two subgenomes with C. sativa , suggesting a novel or 36 cryptic sub-species of C. microcarpa with 19 haploid chromosomes. One C. microcarpa 37 accession (2n = 26) was found to comprise the first two subgenomes of C. sativa suggesting a 38 tetraploid structure. The defined chromosome series among C. microcarpa germplasm, including 39 the newly designated C. neglecta diploid née C. microcarpa , suggested an evolutionary 40 trajectory for the formation of the C. sativa hexaploid genome and re-defined the underlying 41 subgenome structure of the reference genome. of C. microcarpa species in different genebanks suggest that it has a ST values
A mathematical modeling approach to explore kinetics of Chimeric Antigen Receptor (CAR) T-cell Response in glioma: the CARRGO model

Chimeric antigen receptor (CAR) T-cell therapy has shown promise in the treatment of hematological cancers and is currently being investigated for solid tumors including highgrade glioma brain tumors. There is a desperate need to quantitatively study the factors that contribute to the efficacy of CAR T-cell therapy in solid tumors. In this work we use a mathematical model of predator-prey dynamics to explore the kinetics of CAR T-cell killing in glioma: the Chimeric Antigen Receptor t-cell treatment Response in GliOma (CARRGO) model. The model includes rates of cancer cell proliferation, CAR T-cell killing, CAR T-cell proliferation and exhaustion, and CAR T-cell persistence. We use patient-derived and engineered cancer cell lines with an in vitro real-time cell analyzer to parameterize the CARRGO model. We observe that CAR T-cell dose correlates inversely with the killing rate and correlates directly with the net rate of proliferation and exhaustion. This suggests that at a lower dose of CAR T-cells, individual T-cells kill more cancer cells but become more exhausted as compared to higher doses. Furthermore, the exhaustion rate was observed to increase significantly with tumor growth rate and was dependent on level of antigen expression. The CARRGO model highlights nonlinear dynamics involved in CAR T-cell therapy and provides novel insights into the kinetics of CAR T-cell killing. The model suggests that CAR T-cell treatment may be tailored to individual tumor characteristics including tumor growth rate and antigen level to maximize therapeutic benefit.
Korean Alcohol Guidelines for Moderate Drinking Based on Facial Flushing

This study investigated advantages and potential risks associated with drinking alcohol in Koreans based on the alcohol flush reaction. Our investigation reviewed published studies and examined moderate-drinking levels for Koreans based on modified National Institute on Alcohol Abuse and Alcoholism guidelines. Fourteen articles out of a total 198 publications were searched using PubMed, EMBASE, KoreaMed, and RISS (Research Information Sharing Service) databases and selected for review. Individuals without alcohol flush reaction (non-flushers) exhibited lower risks associated with insulin resistance, metabolic syndrome, and hyperhomocysteinemia and their 10-year cardiovascular disease risk when alcohol consumption was ≤8 drinks/wk. Conversely, risks associated with insulin resistance, metabolic syndrome, high blood pressure, prediabetes or type-2 diabetes, and high intraocular pressure and increases in carbohydrate-deficient transferrin, gamma glutamyl transferase, and blood glucose levels were present when >8 drinks were consumed. For individuals with flushing reaction (flushers), advantages were reported in relation to risks of hyperhomocysteinemia when alcohol consumption was ≤4 drinks/wk, whereas consumption of >4 drinks/wk increased the risk of insulin resistance, metabolic syndrome, high blood pressure, pre-diabetes or type-2 diabetes, high-risk colorectal adenoma, and high intraocular pressure and increased carbohydrate-deficient transferrin, gamma glutamyl transferase, and blood glucose levels. The moderate drinking level for Koreans is ≤8 drinks/wk for men aged ≤65 years and ≤4 drinks/wk for men aged over 65. For women, these limits should be half of those for men. Furthermore, individuals with flushing reaction should maintain an alcohol consumption level half of that for non-flushers.
A global upper atmosphere observatory using of lidar on the International Space Station

A global upper atmosphere observatory using of lidar on the International Space Station J. H. Clemmons, S. M. Beck, J. H. Hecht, C. F. Corey, J. C. McLeroy, K. L. Ferrone, J. F. Spann, G. R. Swenson, D. Janches, B. Giles, M. Krainak, A. Yu, S. JonesA concept for hosting a lidar facility for the upper atmosphere on the International Space Station (ISS) is presented and discussed. The concept is based on utilizing an existing Large Space Optics mirror having a 2.37-m aperture as the primary mirror in its receiver. This large aperture provides for hosting several transmitter systems to retrieve density, temperature, and wind measurements for several upper atmospheric species. Thus the concept provides for measurements over a wide altitude range (80-600 km), at various time and spatial resolutions, and hosting on the ISS provides nearly global coverage. The baseline concept includes transmitters and receivers for atomic oxygen (80-500 km), metastable helium (400-600 km), and sodium (80-110 km). The facility is conceived as being flexible such that other transmitter/receiver systems could be added to allow the possibility of other species to be studied, such as iron.The presentation discusses the transformative science that would be gained by such an observatory by combining the nearly global coverage afforded by the ISS orbit with the extension of powerful lidar techniques to high altitudes. The challenges in realizing such an observatory are discussed, as are current plans and partnerships to meet those challenges. The presentation also reports on the development status of several components, primarily various independent transmitter/receiver systems, that are under consideration for the baseline observatory. Several institutions are performing these developments.
Facing the past - recovering historic echodata

A flat panel display device includes a display panel including a plurality of pixels arranged in matrix of rows and columns, a data latch circuit for latching various types of color data to be displayed on a display area having a predetermined resolution on the display panel, a specific color data generation circuit for generating specific color data to be displayed on a non-display area on the display panel, and a timing control circuit for controlling timing such that the specific color data generated from the specific color data generation circuit is displayed on the non-display area simultaneously with an operation of displaying the various types of color data latched by the data latch circuit on the display area.
Peatlands, volcanoes and climate: Ecological and palaeoecological studies in Alaska and Scotland

This thesis investigates direct and indirect volcanic impacts on peatlands using palaeoecological and ecological techniques. The primary approach used is palaeoecological studies across tephra layers. A multi-proxy methodology was adopted including testate amoebae, hurnification and outline macrofossil analysis supported by radiocarbon dating. To allow quantitative interpretation of testate amoebae results a transfer function model was developed for surface wetness and pH. To examine whether it is justified to use tephra layers as evidence of volcanic activity an experiment was carried out to investigate tephra taphonomy. Results show that tephra does move through peat but the ma . ority remains at the surface. In an attempt to characterise the palaeoecological response to volcanic acid deposition an experiment was conducted applying tephra and acids to a Scottish peatland. Results show drastic impacts on peatland plants but impacts on other variables were more equivocal. For the palaeoecological studies a series of peatland sites were sampled in southeast Alaska and on the Kenai Peninsula in south-central Alaska. A number of microscopic and visible tephras were located and subjected to electron microprobe analysis to aid their identification. Results show the great potential of microtephrochronology to extend the distribution of tephra layers in Alaska. Furthermore, results highlight the great size of several eruptions, improve the dating of others and show the presence of previously unrecognised tephras. The macrofossil and testate amoebae results show impacts associated with some tephras but not all. The hurnification results are considered unreliable due to a methodological problem. The most likely cause of the impacts is through volcanic acids and gases or other chemicals adhering to tephra shards. The variability of impacts may be due to the season of eruption. These results have implications for the volcano-climate system, peatland conservation and agriculture.
Spatial partitioning of environmental correlates of avian biodiversity in the conterminous United States

Classification and regression tree (CART) analysis was used to create hierarchically organized models of the distribution of bird species richness across the conterminous United States. Species richness data were taken from the Breeding Bird Survey and were related to climatic and land use data. We were available to the independent variables, yielding an /? 2-type goodness of fit metric of 47.5% deviance explained. The resulting model recognized eleven groups of hexagons, with species richness within each group determined by unique sequences of hierarchically constrained independent variables. Within the hierarchy, climate data accounted for more variability in the bird data, followed by land cover proportion, and then pattern metrics. The model was then used to predict species richness in all 12,500 hexagons of the conterminous United States yielding a map of the distribution of these eleven classes of bird species richness as determined by the environmental correlates. The potential for using this technique to interface biogeographic theory with the hierarchy theory of ecology is discussed.
Multiple hold-outs with stability: improving the generalizability of machine learning analyses of brain-behaviour relationships

Please cite this article as: Mihalik A. , Ferreira F.S. , Moutoussis M. , Ziegler G. , Adams R.A. , Rosa M.J., Prabhu G. , de Oliveira L. , Pereira M. , Bullmore E.T. , Fonagy P., Goodyer I.M. , Jones P.B. , NSPN Consortium, Shawe-Taylor J., Dolan R. & Mourao-Miranda J., Multiple hold-outs with stability: improving the generalizability of machine learning analyses of brain-behaviour relationships, Biological Psychiatry (2020), doi: https://doi.org/10.1016/j.biopsych. 2019.12. 001.
Contrast and agreement among body composition equations in pediatric age: application in Spanish and Venezuelan population.

La finalidad de este trabajo es comparar ecuaciones antropométricas desarrolladas para estimar la adiposidad relativa en edad infantil. Se analizó una muestra de 1125 escolares españoles y 675 venezolanos entre los 6 y los 14 años. El porcentaje de grasa se obtuvo según las ecuaciones de Siri (1961), Slaughter et al. (1988) y Lohman et al. (1984). Para evaluar el acuerdo entre métodos se aplicó un análisis de correlación de Spearman, se calculó el coeficiente de correlación intraclase (CCI) y se aplicó el método Bland-Altman. Los resultados para el % de grasa obtenidos por cada uno de los tres métodos presentaron una buena concordancia aunque no pueden considerarse intercambiables. El modelo de concordancia resultó semejante para las dos poblaciones analizadas.