Miracle-dz/UniFAR-FTUs huggingface dataset:
Classical Music on the Web - User Interfaces and Data Representations

We present a set of web-based user interfaces for explorative analysis and visualization of classical orchestral music and a web API that serves as a backend to those applications; we describe use cases that motivated our developments within the PHENICX project, which promotes a vital interaction between Music Information Retrieval research groups and a world-renowned symphony orchestra. Furthermore, we describe two real-world applications that involve the work presented here. Firstly, our web applications are used in the editorial stage of a periodically released subscription-based mobile app by the Royal Con-certgebouw Orchestra (RCO) 1 , which serves as a content-distribution channel for multi-modally enhanced recordings of classical concerts. Secondly, our web API and user interfaces have been successfully used to provide real-time information (such as the score, and explanatory comments from musicologists) to the audience during a live concert of the RCO.
Integrated reverse left and right ventricular remodelling after MitraClip implantation in functional mitral regurgitation: an echocardiographic study.

AIMS The aim of the present study was to investigate the changes of left and right ventricular (RV) dimensions and function after MitraClip implantation in high-risk surgical patients with severe functional mitral regurgitation (MR). METHODS AND RESULTS Study population included 35 patients with functional MR. All the patients underwent clinical and echocardiographic evaluation at baseline, before discharge and at 6-month follow-up. The mean age was 75 years (63-81), 65.7% (n = 23) was male with a mean logistic EuroSCORE of 20%. Percutaneous mitral valve repair acronym (PMVR) resulted in significantly reduced MR and improved in New York Heart Association functional class. Echocardiography revealed improvement in left ventricular (LV) size and function since discharge with further improvement at 6 months. During the follow-up, a significant improvement in RV function was also observed by the baseline values. At baseline, before discharge and 6 months, respectively, the tricuspid annulus plane systolic excursion (TAPSE) was 16.8 ± 3.9, 18.7 ± 3.4, and 19.3 ± 4.5 mm (P = 0.001); the systolic pulmonary artery pressure (SPAP) was 50.1 ± 6.8, 41.2 ± 6.8, and 38.1 ± 6.8 mmHg (P < 0.0001); and the systolic velocity at the tricuspid annular (RV-Sm) was 8.8 ± 2.9, 10.4 ± 3.5, and 17.7 ± 3.1 cm (P < 0.0001). CONCLUSION MitraClip implantation induces a significant reverse remodelling of LV, with reduction in both diastolic and systolic LV volumes and an increase in the cardiac index. The concomitant reduction in LV filling pressure, obtained after MitraClip implantation, reflects nearly immediately on the haemodynamics of the right sections. In fact, since discharge, we observed both a reverse remodelling of the right sections, with a significant reduction in SPAP, and a significant increase in longitudinal RV systolic function as shown by the increase in TAPSE and RV-Sm.
Risk of fractures with inhaled corticosteroids in COPD: systematic review and meta-analysis of randomised controlled trials and observational studies

Background The effect of inhaled corticosteroids (ICS) on fracture risk in patients with chronic obstructive pulmonary disease (COPD) remains uncertain. The aim of this study was to evaluate the association between ICS and fractures in COPD. Methods MEDLINE, EMBASE, regulatory documents and company registries were searched up to August 2010. Randomised controlled trials (RCTs) of budesonide or fluticasone versus control treatment for COPD (≥24 weeks duration) and controlled observational studies reporting on fracture risk with ICS exposure vs no exposure in COPD were included. Peto OR meta-analysis was used for fracture risk from RCTs while ORs from observational studies were pooled using the fixed effect inverse variance method. Dose–response analysis was conducted using variance-weighted least squares regression in the observational studies. Heterogeneity was assessed using the I2 statistic. Results Sixteen RCTs (14 fluticasone, 2 budesonide) with 17 513 participants, and seven observational studies (n=69 000 participants) were included in the meta-analysis. ICSs were associated with a significantly increased risk of fractures (Peto OR 1.27; 95% CI 1.01 to 1.58; p=0.04; I2=0%) in the RCTs. In the observational studies, ICS exposure was associated with a significantly increased risk of fractures (OR 1.21; 95% CI 1.12 to 1.32; p<0.001; I2=37%), with each 500 μg increase in beclomethasone dose equivalents associated with a 9% increased risk of fractures, OR 1.09 (95% CI 1.06 to 1.12; p<0.001). Conclusion Among patients with COPD, long-term exposure to fluticasone and budesonide is consistently associated with a modest but statistically significant increased likelihood of fractures.
International Journal of Production Research Two-sided U-type Assembly Line Balancing Problem Two-sided U-type Assembly Line Balancing Problem

This article may be used for research, teaching, and private study purposes. Any substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing, systematic supply, or distribution in any form to anyone is expressly forbidden. The publisher does not give any warranty express or implied or make any representation that the contents will be complete or accurate or up to date. The accuracy of any instructions, formulae, and drug doses should be independently verified with primary sources. The publisher shall not be liable for any loss, actions, claims, proceedings, demand, or costs or damages whatsoever or howsoever caused arising directly or indirectly in connection with or arising out of the use of this material. U-type and two-sided assembly lines are two types of design having advantages over traditional straight assembly lines. In this paper, a new line design hybrid of U-type and two-sided lines is presented. A bi-objective 0-1 integer programming model is developed to solve the line balancing problem of the proposed design. Zoning constraints are also considered for the proposed design. A number of test problems from the literature with up to 65 tasks are solved. Benefits of two-sided U-type lines are discussed. 1. Introduction The assembly line balancing (ALB) problem is one of the well-known production problems. For more than 50 years, many studies have been conducted on this subject. During this period various new assembly line design concepts such as U-shaped, two-sided, parallel, flexible, and robotic, etc., have been introduced. And up to now many optimal or heuristic techniques for balancing several types, such as deterministic, stochastic, fuzzy, mixed model, etc., of these lines have been produced. The literature on assembly line balancing is relatively extensive. 2008) can be examined. U-type and two-sided assembly lines are among the more extensively-studied problems in recent years. These two types of design have become prominent due to their advantages over traditional straight assembly lines Yeguï et al. (2010) presented a hybrid assembly line design that benefits the advantages of both types of lines. Yeguï et al. (2010) designed the two-sided assembly line in U shape. While in the entrance arm of the line stations are located on both sides of the line, on the exit arm stations are located only inside the U shape. Thus, the tasks can be assigned to three different locations: first location is outside the U shape at the entrance arm; second location is inside the U …
Development of a Remote Handling System in an Integrated Pyroprocessing Facility

Over the course of a decade-long research programme, the Korea Atomic Energy Research Institute (KAERI) has developed several remote handling systems for use in pyroprocessing research facilities. These systems are now used successfully for the operation and maintenance of processing equipment. The most recent remote handling system is the bridge-transported dual arm servo-manipulator system (BDSM), which is used for remote operation at the world's largest pyroprocess integrated inactive demonstration facility (PRIDE). Accurate and reliable servo-control is the basic requirement for the BDSM to accomplish any given tasks successfully in a hotcell environment. To achieve this end, the hardware and software of a digital signal processor-based remote control system were fully custom-developed and implemented to control the BDSM. To reduce the residual vibration of the BDSM, several input profiles, including input shaping, were carefully chosen and evaluated. Furthermore, a time delay controller was employed to achieve good tracking performance and systematic gain tuning. The experimental results demonstrate that the applied control algorithms are more effective than conventional approaches. The BDSM successfully completed its performance tests at a mock-up and was installed at PRIDE for real-world operation. The remote handling system at KAERI is expected to advance the actualization of pyroprocessing.
Few-View CT reconstruction method based on deep learning

To reduce patient's dose, few-view CT reconstruction promises to be a good attempt. The key to better reconstruction is the sparse view artifacts. In recent years, DL(deep learing) has attracted a lot of attention because its outstanding performance in image processing. We propose a deep learning method for few-view CT reconstuction. Our method directly learns an end-to-end mapping between the full-view/few-view reconstruction. The mapping is represented as a deep convolutional neural network (CNN) that takes the few-view reconstruction image as the input and outputs the full-view one. We further show that traditional Dictionary Learning based reconstruction methods can also be viewed as a deep convolutional network. But unlike traditional methods that handle each component separately, our method jointly optimizes all layers. Our deep CNN has a lightweight structure, yet demonstrates state-of-the-art reconstruction quality, and achieves fast speed for practical on-line usage. We explore different network structures and parameter settings to achieve trade-offs between performance and speed.
Power Totients with Almost Primes

Abstract A natural number n is called a k-almost prime if n has precisely k prime factors, counted with multiplicity. For any fixed k ⩾ 2, let ℱ k (X) be the number of k-th powers mk ⩽ X such that φ(n) = mk for some squarefree k-almost prime n, where φ(·) is the Euler function. We show that the lower bound ℱ k (X) ≫ X 1/k /(log X)2k holds, where the implied constant is absolute and the lower bound is uniform over a certain range of k relative to X. In particular, our results imply that there are infinitely many pairs (p, q) of distinct primes such that (p – 1) (q – 1) is a perfect square.
Role of Neurotrophin Receptor TrkB in the Maturation of Rod Photoreceptors and Establishment of Synaptic Transmission to the Inner Retina

Brain-derived neurotrophic factor (BDNF) acts through TrkB, a receptor with kinase activity, and mitigates light-induced apoptosis in adult mouse rod photoreceptors. To determine whether TrkB signaling is necessary for rod development and function, we examined the retinas of mice lacking all isoforms of the TrkB receptor. Rod migration and differentiation occur in the mutant retina, but proceed at slower rates than in wild-type mice. In postnatal day 16 (P16) mutants, rod outer segment dimensions and rhodopsin content are comparable with those of photoreceptors in P12 wild type (WT). Quantitative analyses of the photoreceptor component in the electroretinogram (ERG) indicate that the gain and kinetics of the rod phototransduction signal in dark-adapted P16 mutant and P12 WT retinas are similar. In contrast to P12 WT, however, the ERG in mutant mice entirely lacks a b-wave, indicating a failure of signal transmission in the retinal rod pathway. In the inner retina of mutant mice, although cells appear anatomically and immunohistochemically normal, they fail to respond to prolonged stroboscopic illumination with the normal expression of c-fos. Absence of the b-wave and failure of c-fos expression, in view of anatomically normal inner retinal cells, suggest that lack of TrkB signaling causes a defect in synaptic signaling between rods and inner retinal cells. Retinal pigment epithelial cells and cells in the inner retina, including Müller, amacrine, and retinal ganglion cells, express the TrkB receptor, but rod photoreceptors do not. Moreover, inner retinal cells respond to exogenous BDNF with c-fos expression and extracellular signal-regulated kinase phosphorylation. Thus, interactions of rods with TrkB-expressing cells must be required for normal rod development.
Analysis of reported SCO2 gene mutations affecting cytochrome c oxidase activity in various diseases

A large number of mutations have been reported in SCO2 (synthesis of cytochrome c oxidase) gene in association with COX deficiency reported in different diseases such as cardioencephalomyopathy, cardiomyopathy and Leigh syndrome. However, very few of these mutations have been functionally analyzed.SCO2 gene encodes for an essential assembly factor for the formation of cytochrome c oxidase (COX). It is a nuclear encoded protein that helps in transfer of copper ions to COX. This study is an attempt to understand the possible effect of these mutations on the structure and function of SCO2 protein, by using different in silico tools. As per Human Gene Mutation Database, total 11 non synonymous variations have been reported in SCO2 gene. Among these 11 variations, only E140K and R171W are functionally proven to cause COX deficiency. They have been used as controls in this study. The remaining variations were further analyzed using ClustalW, SIFT, PolyPhen-2, GOR4, MuPro and Panther softwares. As compared to the results of the controls, most of these variations were predicted to affect the structure of SCO2 protein and hence, may cause COX dysfunction. Thus, we hypothesize that these variations have the potential to result in a disease phenotype and should be investigated by subsequent functional analyses. This will help in an appropriate diagnosis and management of the wide spectrum of COX deficiency diseases.
Analysis of Newspapers Travelers' Tales To Help Students Learn Tourism Motivations

Tourism motivation is an important topic in tourism management studies. To help students better understand this topic, 63 travelers' tales (or personal travelogues) published in travel section of The New York Times were used as data sources to illustrate the application of a tourism motivation analysis framework and teaching method. One exercise and one project were also designed for undergraduate and postgraduate students, respectively to peruse this data source. It is hoped the dataset can enrich lecturers' teaching materials and the framework proposed can help students analyze, categorize, and synthesize tourism motivations. It is argued and suggested that students will develop a more proactive learning attitude and critical thinking skills after completing the suggested project. Additionally, some future research that could peruse this dataset is also suggested.
PREDICTORS AND CONSEQUENCES OF DIFFERENTIATED PRACTICES ON SOCIAL NETWORK SITES

Applying a typology of social network site (SNS) usage that takes into consideration the intensity with which people use such sites, this piece offers an empirical investigation of how users' social practices on SNSs differ and whether different levels of engagement have consequences for academic performance. We rely on a unique survey-based data set representing a diverse group of young adults to answer these questions. We find, not surprisingly, that the more intense users of such sites engage in more social activities on SNSs than those who spend less time on them and only use one such site. This finding holds in the realm of both stronger-tie activities and weaker-tie activities, that is, social practices involving one's close friends as well as less established ties. Our analyses suggest gender differences in level of engagement with SNS social practices. Women pursue more stronger-tie activities than men, such as interacting with existing friends. In contrast, women engage in fewer weaker-tie activities than men, such as developing new relationships on such sites. However, neither SNS usage intensity nor social practices performed on these sites is systematically related to students' academic performance, findings that challenge some previous claims to the contrary.
Better Necessary Conditions for Rearrangeably Nonblocking f-cast dary Multi-log Networks under Fanout and Crosstalk Constraints

We derive necessary conditions for the d-ary multilog switching networks to be f -cast rearrangeably nonblocking when the input stage does not have fanout capability, with and without crosstalk-free constraint. In electronic switching networks, connection routes cannot share a link but they can share a switching node. This is the case when there is no crosstalkfree constraint. In optical switching networks, it is often desirable to enforce the crosstalk-free constraint which forbids connection routes to share switching nodes. The most novel contribution of this paper is the analytical technique, which addresses the problem from an algebraic angle. Our necessary conditions are much better than previously known conditions. Moreover, our results are on general d-ary multi-log networks, while known results are on 2-ary networks only.
Evaluating the Role of "Nothing to Lose" Attitudes on Risky Behavior in Adolescence

This article examines the extent to which adolescents' expectations about their future in terms of health and education affect their risk-taking behavior. With data from the National Longitudinal Study of Adolescent Health, we test the theory that a "nothing to lose" attitude about the future predicts greater involvement in risky behaviors involving early sexual intercourse, selling drugs, and weapon use. We examine the effects of both individual- and school-level conditions. Results provide mixed support for our "nothing to lose" hypothesis. We do find noteworthy school-level effects of "school climate," including aggregate expectations, mental health, and the prevalence of single-mother families, that influence adolescent risk-taking behavior more than school measures of SES.
Kynurenine Pathway Pathologies: do Nicotinamide and Other Pathway Co-Factors have a Therapeutic Role in Reduction of Symptom Severity, Including Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM)

The definition of dual tryptophan pathways has increased the understanding of the mind-body, body-mind dichotomy. The serotonergic pathway highlights the primary (endogenous) psychiatric disorders. The up-regulation of the kynurenine pathway by physical illnesses can cause neuropathic and immunological disorders1 associated with secondary neuropsychiatric symptoms. Tryptophan and nicotinamide deficiencies fall within the protein energy malnutrition (PEM) spectrum. They can arise if the kynurenine pathway is stressed by primary or secondary inflammatory conditions and the consequent imbalance of available catabolic/anabolic substrates may adversely influence convalescent phase efficiency. The replacement of depleted or reduced NAD+ levels and other cofactors can perhaps improve the clinical management of these disorders. Chronic fatigue syndrome (CFS) and fibromyalgia (FM) appear to meet the criteria of a tryptophan-kynurenine pathway disorder with potential neuroimmunological sequelae. Aspects of some of the putative precipitating factors have been previously outlined.2,3 An analysis of the areas of metabolic dysfunction will focus on future directions for research and management.
Surgical treatment of nontuberculous empyema.

Emphysema is still a serious thoracic infection, despite the development of increasingly powerful antimicrobial agents. Although it appears to be on the decline in the general population,1-4the incidence of empyema continues to be significant in the indigent population. Since relatively little attention has been paid to empyema in recent medical literature, this report will present our experience with thoracic empyema at the San Francisco General Hospital from 1950 to 1968. The etiology, the changing character of infecting bacterial flora, and the results of medical and surgical therapy will be discussed. Clinical Material From 1950 to 1968, 130 cases of nontuberculous empyema were treated at San Francisco General Hospital. There were 103 males and 27 females, including eight children under the age of 10. There were 36 cases of empyema from 1950 to 1955, 58 cases from 1956 to 1961, and 36 cases from 1962 to 1968. The number
Better the Devil you know? Synthetic and confederal understandings of European unification

In the wake of the Single European Act and the Maastricht Treaty there has been much work undertaken to improve the theorisation of both the politics of the European Union and the unification process under way in Western Europe. This article argues that the confederal account of the two proposed by Murray Forsyth has been mistakenly neglected, and that it is of greater relevance than the waning orthodox international relations‐derived theories of neo‐functionalism and neo‐realism. The current vogue for attempting a synthesis of the latter is evidence of their enfeebled condition, and has proved to be fruitless because the theories are united only in their increasingly evident redundancy. The emergence of a recognisable, if incomplete, Europolity after the ratification of the Maastricht Treaty must refocus attention on the confederal analysis; the price for theoretical rigour is the rejection of the familiar but unhelpful traditional frame of enquiry.
Exploring circulating micro‐RNA in the neoadjuvant treatment of breast cancer

Breast cancer is the most frequently diagnosed malignancy amongst females worldwide. In recent years the management of this disease has transformed considerably, including the administration of chemotherapy in the neoadjuvant setting. Aside from increasing rates of breast conserving surgery and enabling surgery via tumour burden reduction, use of chemotherapy in the neoadjuvant setting allows monitoring of in vivo tumour response to chemotherapeutics. Currently, there is no effective means of identifying chemotherapeutic responders from non‐responders. Whilst some patients achieve complete pathological response (pCR) to chemotherapy, a good prognostic index, a proportion of patients derive little or no benefit, being exposed to the deleterious effects of systemic treatment without any knowledge of whether they will receive benefit. The identification of predictive and prognostic biomarkers could confer multiple benefits in this setting, specifically the individualization of breast cancer management and more effective administration of chemotherapeutics. In addition, biomarkers could potentially expedite the identification of novel chemotherapeutic agents or increase their efficacy. Micro‐RNAs (miRNAs) are small non‐coding RNA molecules. With their tissue‐specific expression, correlation with clinicopathological prognostic indices and known dysregulation in breast cancer, miRNAs have quickly become an important avenue in the search for novel breast cancer biomarkers. We provide a brief history of breast cancer chemotherapeutics and explore the emerging field of circulating (blood‐borne) miRNAs as breast cancer biomarkers for the neoadjuvant treatment of breast cancer. Established molecular markers of breast cancer are outlined, while the potential role of circulating miRNAs as chemotherapeutic response predictors, prognosticators or potential therapeutic targets is discussed.