Miracle-dz/UniFAR-FTUs huggingface dataset:
Research on privacy preserving method based on T-closeness model

T-closeness model is a better method for data publishing privacy preserving technology, but the traditional t-closeness method is more complex. Based on clustering idea, the t-closeness model is implemented in a simpler way. On this basis, in order to optimize the data availability and privacy protection effect at the same time, the parameter selection and adjustment method of the anonymous method is proposed. Experimental results show that this method can effectively implement the t-closeness model, while ensuring the availability of data, and prevent privacy leaks.
Personalized precision medicine in extreme preterm infants with transient neonatal diabetes mellitus

Abstract Although hyperglycemia is common in neonates, especially preterm infants, a diagnosis of neonatal diabetes mellitus (NDM) is rarely made. NDM can be permanent (45%), transient (45%) or syndromic (10%). Of the 95% of identifiable mutations for NDM, methylation defects in 6q24, KCNJ11, ABCC8, and INS account for the majority. Two cases of transient NDM in extremely preterm, 24 weeks’ gestational age (GA) triplets, due to a missense mutation c.685G>A in the KCNJ11 gene are presented. Both patients were successfully transitioned from insulin to Glyburide (Glibenclamide) at 2 months of age. Comprehensive genetic testing with targeted next-generation sequencing and 6q24 methylation analysis helps identify monogenic diabetes early, thereby improving metabolic and glycemic control when patients with potassium channel mutations are started on sulfonylurea (SU) treatment.
Kdm5/Lid Regulates Chromosome Architecture in Meiotic Prophase I Independently of Its Histone Demethylase Activity

During prophase of the first meiotic division (prophase I), chromatin dynamically reorganises to recombine and prepare for chromosome segregation. Histone modifying enzymes are major regulators of chromatin structure, but our knowledge of their roles in prophase I is still limited. Here we report on crucial roles of Kdm5/Lid, one of two histone demethylases in Drosophila that remove one of the trimethyl groups at Lys4 of Histone 3 (H3K4me3). In the absence of Kdm5/Lid, the synaptonemal complex was only partially formed and failed to be maintained along chromosome arms, while localisation of its components at centromeres was unaffected. Kdm5/Lid was also required for karyosome formation and homologous centromere pairing in prophase I. Although loss of Kdm5/Lid dramatically increased the level of H3K4me3 in oocytes, catalytically inactive Kdm5/Lid can rescue the above cytological defects. Therefore Kdm5/Lid controls chromatin architecture in meiotic prophase I oocytes independently of its demethylase activity.
Crowdsourcing the Installation and Maintenance of Indoor Localization Infrastructure to Support Blind Navigation

Indoor navigation systems can make unfamiliar buildings more accessible for people with vision impairments, but their adoption is hampered by the effort of installing infrastructure and maintaining it over time. Most solutions in this space require augmenting the environment with add-ons, such as Bluetooth beacons. Installing and calibrating such infrastructure requires time and expertise. Once installed, localization accuracy often degrades over time as batteries die, beacons go missing, or otherwise stop working. Even localization systems installed by experts can become unreliable weeks, months, or years after the installation. To address this problem, we created LuzDeploy: a physical crowdsourcing system that organizes non-experts for the installation and long-term maintenance of a Bluetooth-based navigation system. LuzDeploy simplifies the tasks required to install and maintain the localization infrastructure, thus making a crowdsourcing approach feasible for non-experts. We report on a field deployment where 127 participants installed and maintained a blind navigation system over several months in a 7-story building, completing 455 tasks in total. We compare the accuracy of the system installed by participants to an installation completed by experts with specialized equipment. LuzDeploy aims to improve the sustainability of indoor navigation systems to encourage widespread adoption outside of research settings.
piRNA-3312: A Putative Role for Pyrethroid Resistance in Culex pipiens pallens (Diptera: Culicidae)

Abstract Piwi-interacting RNAs (piRNAs) are a newly identified class of small noncoding RNAs. They are associated with chromatin organization, messenger RNA stability, and genome structure. Although the overexpression of piRNA-3312 in deltamethrin-susceptible (DS) strain of Culex pipiens pallens (L.) was observed in our previous large-scale transcriptome data, the roles of piRNA in insecticide resistance have not been clearly defined. The aim of the present study was to investigate how piRNA-3312 is involved in insecticide resistance. The lower expression level of piRNA-3312 in deltamethrin-resistant (DR) strain of Cx. pipiens pallens was confirmed by quantitative real time polymerase chain reaction (qRT-PCR). Overexpression of piRNA-3312 in the DR strain made the mosquitoes more sensitive to deltamethrin, whereas inhibiting the expression of piRNA-3312 in the DS strain made the mosquitoes more resistant to deltamethrin. Piwi-interacting RNA-3312 was also found to bind 3′ UTR (Untranslated Regions) of gut esterase 1 gene and could induce its degradation. In addition, knockdown of gut esterase 1 gene increased the sensitivity of DR strain to deltamethrin. In conclusion, we found that piRNA-3312 targeted the gut esterase 1 gene to negatively regulate the insecticide resistance. This finding facilitates the understanding of various functions of piRNAs and their association with insecticide resistance.
Human Endometrial Reconstitution From Somatic Stem Cells: The Importance of Niche-Like Cells

Endometrial regeneration has long been proposed to be mediated by stem cells, but the isolation of endometrial stem cells has been hampered by a lack of validated markers. Specific markers would enable isolation of these stem cells, thereby promoting advancements in regenerative medicine for the treatment of endometrial diseases and dysfunctions. We sought to investigate the regenerative ability of human endometrial positive for sushi domain containing 2/intercellular adhesion molecule 1 (SUSD2+/ICAM1+) cells and Side Population cell lines in a xenograft mice model. The injection of total endometrial cell suspensions and Side Population cell lines under kidney capsules induced neoformation of human endometrium verified by the presence of typical endometrial markers (vimentin, cytokeratin 18, and progesterone receptor) by immunofluorescence. Total endometrial cell types promoted a better reconstitution in comparison to injecting ICAM1+ and SUSD2+ cells alone. The endometrial fraction is probably acting as a niche, resulting in increased reconstruction efficiency of pure fractions. Human engrafted cells were localized near blood vessels and induced the proliferation of surrounding cells. Our results suggest that human endometrial Side Population, a heterogeneous population possibly harboring endometrial stem cells, has the optimum capacity to regenerate endometrial-like tissue. In contrast, cells positive for single stem cell markers SUSD2 and ICAM1 have minimally functional regenerative capacities in the absence of niche-like cells.
Overexpression of ß-Arrestin1 in the Rostral Ventrolateral Medulla Downregulates Angiotensin Receptor and Lowers Blood Pressure in Hypertension

Background: Hypertension is characterized by sympathetic overactivity, which is associated with an enhancement in angiotensin receptor type I (AT1R) in the rostral ventrolateral medulla (RVLM). β-arrestin1, a canonical scaffold protein, has been suggested to show a negative effect on G protein-coupled receptors via its internalization and desensitization and/or the biased signaling pathway. The major objectives of the present study were to observe the effect of β-arrestin1 overexpression in the RVLM on cardiovascular regulation in spontaneously hypertensive rats (SHR), and further determine the effect of β-arrestin1 on AT1R expression in the RVLM. Methods: The animal model of β-arrestin1 overexpression was induced by bilateral injection of adeno-associated virus containing Arrb1 gene (AAV-Arrb1) into the RVLM of WKY and SHR. Results: β-arrestin1 was expressed on the pre-sympathetic neurons in the RVLM, and its expression in the RVLM was significantly (P < 0.05) downregulated by an average of 64% in SHR than WKY. Overexpression of β-arrestin1 in SHR significantly decreased baseline levels of blood pressure and renal sympathetic nerve activity, and attenuated cardiovascular effects induced by RVLM injection of angiotensin II (100 pmol). Furthermore, β-arrestin1 overexpression in the RVLM significantly reduced the expression of AT1R by 65% and NF-κB p65 phosphorylation by 66% in SHR. It was confirmed that β-arrestin1 overexpression in the RVLM led to an enhancement of interaction between β-arrestin1 and IκB-α. Conclusion: Overexpression of β-arrestin1 in the RVLM reduces BP and sympathetic outflow in hypertension, which may be associated with NFκB-mediated AT1R downregulation.
Effect of early goal directed therapy in the treatment of severe sepsis and/or septic shock

Abstract Background: Many investigators have reproduced the mortality reduction shown in the original trial of early goal directed therapy (EGDT) in patients with severe sepsis and/or septic shock. Three large randomized controlled trials (RCTs) found neutral results when compared to usual care and a modified form of EGDT. Some have interpreted these studies as a reason to question the efficacy of EGDT. Objectives: The purpose of this study was to comprehensively examine the effect of EGDT in the treatment of severe sepsis and/or septic shock in the literature. Methods: A systematic review and meta-analysis of RCTs and prospective studies were performed, which extracted studies from PubMed, Elsevier ScienceDirect, Cochrane, Clinicaltrials.gov, Google Scholar, China Knowledge Resource Integrated Database, and Wanfang Database. The mortality trend in the control group from included studies was analyzed. Results: Seven RCTs and twelve prospective studies enrolling 3502 EGDT and 3791 usual care participants were included in the analysis. EGDT was found to reduce overall mortality compared to usual care groups. This reduction in mortality was apparent in prospective and randomized control trials conducted before 2010. Over this time period there was a reduction in mortality in patients receiving usual care. Limitations: This conclusion was limited by the small size of some selected studies and complicated by the long range of time during the conduction of these studies. These studies were further biased because of the lack of blinding and the crossover of care between the EGDT and usual care groups. Conclusions: EGDT significantly reduced mortality in patients with severe sepsis and/or septic shock over 15 years since its publication. Recent studies examining usual care with EGDT have similar mortality benefit because of the diminished treatment effect. This treatment effect is diminished for multiple reasons. With progress in the management of this disease the benefit of EGDT on overall mortality has become comparable with the usual care for sepsis patients. This is because many of the components of EGDT have been incorporated into usual care protocols. As a result, the conclusion that EGDT is ineffective cannot be made. A more rigorous RCT which adjusts for the factors that narrows the treatment effect between groups is required. Given the current state of sepsis care and equipoise that exist, this would be difficult.
Cracking in polylactide spherulites

A polylactide of high optical purity was crystallized between 100 and 140 °C, in-between two glass slides, and its morphology was investigated by polarizing optical microscopy, scanning electron microscopy, and atomic force microscopy, during subsequent heating and cooling cycles between −15 °C and the crystallization temperature. It was found that dark circular rings show up on cooling on top of the spherulites and represent cracks of about 300 nm in width. This phenomenon is completely reversible, and the heating–cooling curves are centered at about 56 °C, which coincide with the Tg of polylactide. © 2005 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 43: 3308–3315, 2005
Sex in an uncertain world: environmental stochasticity helps restore competitive balance between sexually and asexually reproducing populations

Like many organisms, individuals of the freshwater ostracod species Eucypris virens exhibit either obligate sexual or asexual reproductive modes. Both types of individual routinely co‐occur, including in the same temporary freshwater pond (their natural habitat in which they undergo seasonal diapause). Given the well‐known two‐fold cost of sex, this begs the question of how sexually reproducing individuals are able to coexist with their asexual counterparts in spite of such overwhelming costs. Environmental stochasticity in the form of ‘false dawn’ inundations (where the first hydration is ephemeral and causes loss of early hatching individuals) may provide an advantage to the sexual subpopulation, which shows greater variation in hatching times following inundation. We explore the potential role of environmental stochasticity in this system using life‐history data analysis, climate data, and matrix projection models. In the absence of environmental stochasticity, the population growth rate is significantly lower in sexual subpopulations. Climate data reveal that ‘false dawn’ inundations are common. Using matrix projection modelling with and without environmental stochasticity, we demonstrate that this phenomenon can restore appreciable balance to the system, in terms of population growth rates. This provides support for the role of environmental stochasticity in helping to explain the maintenance of sex and the occurrence of geographical parthenogenesis.
Formation of the first stars

Understanding the formation of the first stars is one of the frontier topics in modern astrophysics and cosmology. Their emergence signalled the end of the cosmic dark ages, a few hundred million years after the Big Bang, leading to a fundamental transformation of the early Universe through the production of ionizing photons and the initial enrichment with heavy chemical elements. We here review the state of our knowledge, separating the well understood elements of our emerging picture from those where more work is required. Primordial star formation is unique in that its initial conditions can be directly inferred from the Λ cold dark matter (ΛCDM) model of cosmological structure formation. Combined with gas cooling that is mediated via molecular hydrogen, one can robustly identify the regions of primordial star formation, the so-called minihalos, having total masses of ∼106 M⊙ and collapsing at redshifts z ≃ 20–30. Within this framework, a number of studies have defined a preliminary standard model, with the main result that the first stars were predominantly massive. This model has recently been modified to include a ubiquitous mode of fragmentation in the protostellar disks, such that the typical outcome of primordial star formation may be the formation of a binary or small multiple stellar system. We will also discuss extensions to this standard picture due to the presence of dynamically significant magnetic fields, of heating from self-annihalating WIMP dark matter, or cosmic rays. We conclude by discussing possible strategies to empirically test our theoretical models. Foremost among them are predictions for the upcoming James Webb space telescope (JWST), to be launched ∼2018, and for ‘stellar archaeology’, which probes the abundance pattern in the oldest, most-metal poor stars in our cosmic neighborhood, thereby constraining the nucleosynthesis inside the first supernovae.
Information Security in Mobile Databases

During the last decade the decrease in the size of computing machinery, coupled with the increase in their computing power have lend to the development of the concept of mobile computing. Effects of this new vision can be seen currently in the flourishing numbers of mobile telephones and portable computing units. In the current work we investigate some issues concerning the security of databases and database systems in the mobile computing environment. We present a scheme for end-to-end secure data transfer between one mobile computing element to another based on a recent protocol for key distribution. Secure data transfer is crucial as a foundation to providing other more complex interactions between the various mobile computing elements. Following this we also present an extension to the scheme, applicable for the storage of data in a mobile database, allowing for remote accessibility of the data in a secure manner. Disciplines Physical Sciences and Mathematics Publication Details Thomas Hardjono and Jennifer Seberry, Information security in mobile databases, Sixth Australasian Database Conference, Glenelg, South Australia, February, 1995. This conference paper is available at Research Online: http://ro.uow. edu.au/infopapers/1121 [246] Rep Tho~as Hardjono and Jennifer Seberry, Information security in mobile databases, Szxth Australasian Database Conference, (R Sacks and J Zobel, (Eds.)), 17(2), conference held at Glenelg, South Australia, February, 1995. Information Security in Mobile Databases
Night Shift Work and Risk of Depression: Meta-analysis of Observational Studies

This study aimed to assess whether night shift work is associated with the risk of depression by using a meta-analysis of observational studies. We searched PubMed and EMBASE in August, 2016 to locate eligible studies and investigated the association between night shift work and the risk of depression, reporting outcome measures with adjusted odds ratios (ORs) or relative risks (RRs) and 95% confidence intervals (CIs). In the meta-analysis of a total of 11 observational studies with 9 cross-sectional study, 1 longitudinal study, and 1 cohort study, night shift work was significantly associated with an increased risk of depression (OR/RR, 1.43; 95% CI, 1.24–1.64; I2 = 78.0%). Also, subgroup meta-analyses by gender, night shift work duration, type of occupation, continent, and type of publication showed that night shift work was consistently associated with the increased risk of depression. The current meta-analysis suggests that night shift work is associated with the increased risk of depression. However, further large prospective cohort studies are needed to confirm this association.
Food, Fuel, and Freeways: An Iowa perspective on how far food travels, fuel usage, and greenhouse gas emissions

Most consumers do not understand today’s highly complex global food system. Much of the food production and processing occurs far away from where they live and buy groceries. External environmental and community costs related to the production, processing, storage, and transportation of the food are seldom accounted for in the food’s price, nor are consumers made aware of these external costs. Examples of external environmental costs are the increased amount of fossil fuel used to transport food long distances, and the increase in greenhouse gas emissions resulting from the burning of these fuels.
Cross-Lingual Knowledge Validation Based Taxonomy Derivation from Heterogeneous Online Wikis

Creating knowledge bases based on the crowd-sourced wikis, like Wikipedia, has attracted significant research interest in the field of intelligent Web. However, the derived taxonomies usually contain many mistakenly imported taxonomic relations due to the difference between the user-generated subsumption relations and the semantic taxonomic relations. Current approaches to solving the problem still suffer the following issues: (i) the heuristic-based methods strongly rely on specific language dependent rules. (ii) the corpus-based methods depend on a large-scale high-quality corpus, which is often unavailable. In this paper, we formulate the cross-lingual taxonomy derivation problem as the problem of cross-lingual taxonomic relation prediction. We investigate different linguistic heuristics and language independent features, and propose a cross-lingual knowledge validation based dynamic adaptive boosting model to iteratively reinforce the performance of taxonomic relation prediction. The proposed approach successfully overcome the above issues, and experiments show that our approach significantly outperforms the designed state-of-the-art comparison methods.
The nexus of nursing leadership and a culture of safer patient care

AIMS AND OBJECTIVES To explore the connection between +6 nursing leadership and enhanced patient safety. BACKGROUND Critical reports from the Institute of Medicine in 1999 and Francis QC report of 2013 indicate that healthcare organisations, inclusive of nursing leadership, were remiss or inconsistent in fostering a culture of safety. The factors required to foster organisational safety culture include supportive leadership, effective communication, an orientation programme and ongoing training, appropriate staffing, open communication regarding errors, compliance to policy and procedure, and environmental safety and security. As nurses have the highest patient interaction, and leadership is discernible at all levels of nursing, nurse leaders are the nexus to influencing organisational culture towards safer practices. DESIGN The position of this article was to explore the need to form a nexus between safety culture and leadership for the provision of safe care. CONCLUSIONS Safety is crucial in health care for patient safety and patient outcomes. A culture of safety has been exposed as a major influence on patient safety practices, heavily influenced by leadership behaviours. The relationship between leadership and safety plays a pivotal role in creating positive safety outcomes for patient care. A safe culture is one nurtured by effective leadership. RELEVANCE TO PRACTICE Patient safety is the responsibility of all healthcare workers, from the highest executive to the bedside nurse, thus effective leadership throughout all levels is essential in engaging staff to provide high quality care for the best possible patient outcomes.
Biologics in Inflammatory and Immunomediated Arthritis.

BACKGROUND Biologic drugs, introduced in clinical practice almost twenty years ago, represent nowadays a prominent treatment option in patients with chronic inflammatory arthritis, such as Rheumatoid Arthritis, Psoriatic Arthritis and Spondyloarthritis, that include ankylosing spondylitis and non-radiographic axial spondyloarthritis. METHODS Several compounds targeting different pathways have been marketed and approved for the treatment of inflammatory arthritis, with a significant impact on the clinical outcomes and the natural history of the diseases. RESULTS There are currently seven classes of biologics that are available for the treatment of inflammatory arthritis, each inhibiting a different aspect of the immune-driven inflammatory pathway. They include: • Tumor Necrosis Factor (TNF) inhibitors (infliximab, adalimumab, etanercept, golimumab and certolizumab pegol); • Interleukin-1 (IL-1) receptor antagonists (anakinra); • Interleukin-6 (IL-6) inhibition (tocilizumab); • Interleukin-12/23 (IL23) inhibition (ustekinumab); • Interleukin-17 (IL-17) inhibition (secukinumab); • B-cell inhibition (anti-CD20, rituximab); • T-cell costimulation inhibition (anti-CTLA-4, abatacept). CONCLUSION In this review, we will focus on the role of biologic drugs in the treatment strategies for inflammatory arthritis.