Miracle-dz/UniFAR-FTUs huggingface dataset:
Old-new ERP effects and remote memories: the late parietal effect is absent as recollection fails whereas the early mid-frontal effect persists as familiarity is retained

Understanding the electrophysiological correlates of recognition memory processes has been a focus of research in recent years. This study investigated the effects of retention interval on recognition memory by comparing memory for objects encoded four weeks (remote) or 5 min (recent) before testing. In Experiment 1, event related potentials (ERPs) were acquired while participants performed a yes-no recognition memory task involving remote, recent and novel objects. Relative to correctly rejected new items, remote and recent hits showed an attenuated frontal negativity from 300–500 ms post-stimulus. This effect, also known as the FN400, has been previously associated with familiarity memory. Recent and remote recognition ERPs did not differ from each other at this time-window. By contrast, recent but not remote recognition showed increased parietal positivity from around 500 ms post-stimulus. This late parietal effect (LPE), which is considered a correlate of recollection-related processes, also discriminated between recent and remote memories. A second, behavioral experiment confirmed that remote memories unlike recent memories were based almost exclusively on familiarity. These findings support the idea that the FN400 and LPE are indices of familiarity and recollection memory, respectively and show that remote and recent memories are functionally and anatomically distinct.
PARP inhibition: targeting the Achilles' heel of DNA repair to treat germline and sporadic ovarian cancers

Purpose of review Ovarian cancer remains the gynaecological malignancy with the highest mortality in the Western world. The strategy of identifying biologically distinct subgroups of ovarian cancer by means of clinical characteristics, histology and molecular profiling is an exciting prospect in personalizing and improving therapy for ovarian cancer. Recent findings Preclinical recognition that BRCA1 and BRCA2-associated tumours are very sensitive to inhibition of poly-ADP ribose polymerase (PARP), a key molecule in DNA repair, led to ovarian cancer patients with germline BRCA1 and BRCA2 mutations being treated with the PARP inhibitor olaparib (AZD2281, KU-0059436; KuDOS/Astra-Zeneca). The initial trials of olaparib in this patient population demonstrated an impressive rate of clinical benefit. Furthermore, tumours from patients with sporadic ovarian cancer have been found to commonly have somatic BRCA1 and BRCA2 mutations or other defects in DNA repair, with the implication that PARP inhibition may also have a role in treating these patients. Summary In this review, we discuss DNA repair mechanisms and strategies used to target them in oncology, our current experience with PARP inhibition in BRCA1 and BRCA2-mutation associated and sporadic ovarian cancer, as well as current issues in the clinical development of these agents.
Dual-Link Failure Resiliency Through Backup Link Mutual Exclusion

Networks employ link protection to achieve fast recovery from link failures. While the first link failure can be protected using link protection, there are several alternatives for protecting against the second failure. This paper formally classifies the approaches to dual-link failure resiliency. One of the strategies to recover from dual-link failures is to employ link protection for the two failed links independently, which requires that two links may not use each other in their backup paths if they may fail simultaneously. Such a requirement is referred to as backup link mutual exclusion (BLME) constraint and the problem of identifying a backup path for every link that satisfies the above requirement is referred to as the BLME problem. This paper develops the necessary theory to establish the sufficient conditions for existence of a solution to the BLME problem. Solution methodologies for the BLME problem is developed using two approaches by: 1) formulating the backup path selection as an integer linear program; 2)developing a polynomial time heuristic based on minimum cost path routing. The ILP formulation and heuristic are applied to six networks and their performance is compared with approaches that assume precise knowledge of dual-link failure. It is observed that a solution exists for all of the six networks considered. The heuristic approach is shown to obtain feasible solutions that are resilient to most dual-link failures, although the backup path lengths may be significantly higher than optimal. In addition, the paper illustrates the significance of the knowledge of failure location by illustrating that network with higher connectivity may require lesser capacity than one with a lower connectivity to recover from dual-link failures.
Cellular Automata Complexity Threshold and Classification: A Geometric Perspective

This paper presents the results of mathematical experiments on the socalled ! orientation vector. " It looks at complexity in terms of three perspectives: Wolfram, Langton, and Chua. Critically, we consider Chua#s geometrical complexity index and a complexity-based classification of elementary cellular automata. Ideas in terms of solutions for ordinary differential equations and complexity measurements are proposed to the research community for discussion.
Generalized model predictive static programming and its application to 3D impact angle constrained guidance of air-to-surface missiles

A new `generalized model predictive static programming (G-MPSP)' technique is presented in this paper in the continuous time framework for rapidly solving a class of finite-horizon nonlinear optimal control problems with hard terminal constraints. A key feature of the technique is backward propagation of a small-dimensional weight matrix dynamics, using which the control history gets updated. This feature, as well as the fact that it leads to a static optimization problem, are the reasons for its high computational efficiency. It has been shown that under Euler integration, it is equivalent to the existing model predictive static programming technique, which operates on a discrete-time approximation of the problem. Performance of the proposed technique is demonstrated by solving a challenging three-dimensional impact angle constrained missile guidance problem. The problem demands that the missile must meet constraints on both azimuth and elevation angles in addition to achieving near zero miss distance, while minimizing the lateral acceleration demand throughout its flight path. Both stationary and maneuvering ground targets are considered in the simulation studies. Effectiveness of the proposed guidance has been verified by considering first order autopilot lag as well as various target maneuvers.
Interaction of actin filaments with microtubules

Several cytological observations support the idea that actin filaments interact with microtubules, but the strongest evidence comes from biochemical experiments. The cytological observations include the colocalization of microtubules and actin in the mitotic spindle of dividing cells by electron microscopy (1-3) and light microscopy with fluorescent probes for actin (4-6) . There is, however, debate about the concentration of actin in the spindle relative to the cytoplasm (7) . There is one report (8) that fluorescent phalloidin (a peptide that binds to actin filaments) does not bind to the spindle-an observation that is inconsistent with the other cytological studies. There also is a report (9) of fine, filamentous material, called microtrabeculae, associated with microtubules in interphase cells prepared by critical point drying . The chemical composition of these microtrabeculae has yet to be established, but it is conceivable that they are, in fact, actin filaments . A second impetus for investigating actin-microtubule interactions at the molecular level has been the difficulty of identifying an energy-transducing enzyme associated directly with microtubules that might power the wide variety of microtubule-dependent movements observed in cells (10, 11) . A number ofinvestigators have sought a cytoplasmic homologue of the microtubule-interactive, energy-transducing enzyme, dynein, found in the axonemes of cilia and flagella. A small amount of a high molecular weight ATPase that could be related to dynein is associated with isolated brain microtubules (12), but most of the ATPase activity in these preparations is clearly a component of membrane-bounded vesicles (13). Sea urchin eggs also have a high molecular weight ATPase that shares some properties with axonemal dynein, but not enough material has been purified to make adefinitive identification (14, 15) . Vanadate and ENHA (erythro-9-[3-(2-hydroxynonyl)]adenine, an ATP analog) inhibit both axonemal dynein and some types of microtubule-dependent, cytoplasmic movements (16-18), leading to speculation that these movements require a cytoplasmic dynein . These inhibitors are not specific for dynein, and in at least one cell, vanadate inhibits ciliary beating but not saltatory, microtubule-dependent particle movements (19) . Until there is stronger evidence for cytoplasmic dynein, we feel that it is wise to consider the possibility that microtubuledependent movements are powered by another energy-transducing enzyme that is not bound directly to microtubules . At
Smart Predictive Trigger for Effective Handover in Wireless Networks

Roaming across heterogeneous wireless networks poses a challenging issue in mobility management such as seamless and efficient handover to reduce end-user's service interruption. Efficient techniques for seamless handover between access points (APs) when user roams from one area to another can be categorized into three stages in conventional way, i) initiation, ii) preparation, and iii) execution. However, frequent handover may overload the network with signalling traffic and causes call dropping to increase as well. This paper takes a deeper look at predictive triggers at the link layer. With an appropriate implementation of predictive triggering algorithms, early handover initiation and preparation could be performed. This paper addresses the investigation on predictive and accurate mechanisms to generate a handover trigger.
Big wireless measurement campaigns: are they really worth the price?

Performance evaluation of mobile wireless networking has to cope with two main issues: representativeness and feasibility. These two aspects are often contradictory because analyses must be thorough and, at the same time, neither costly nor time consuming. In a wireless network, the number of variables is potentially large and unexpected physical phenomena may occur at any time. Thus, balancing representativeness and feasibility often requires trace-driven approaches where the system is evaluated using real data collected from measurement campaigns. In this paper, we discuss possible criteria to allow researchers to find the traces which better fit their needs and expectations. Moreover, we suggest metrics that could be used to evaluate the value added by a new dataset with regard to existing ones. If possible, these metrics should be estimated before investing time and resources in a measurement campaign if this latter would not bring significant insights beyond those already available.
Plasminogen activator inhibitors.

Chemicals/CAS: fibrin, 9001-31-4; plasminogen activator inhibitor, 105844-41-5; plasminogen activator, 9039-53-6; Carrier Proteins; Glycoproteins; Plasminogen Activators, EC 3.4. 21. -; Plasminogen Inactivators; Protease Inhibitors; protease-nexin
Temporal Analysis of Motif Mixtures Using Dirichlet Processes

In this paper, we present a new model for unsupervised discovery of recurrent temporal patterns (or motifs) in time series (or documents). The model is designed to handle the difficult case of multivariate time series obtained from a mixture of activities, that is, our observations are caused by the superposition of multiple phenomena occurring concurrently and with no synchronization. The model uses nonparametric Bayesian methods to describe both the motifs and their occurrences in documents. We derive an inference scheme to automatically and simultaneously recover the recurrent motifs (both their characteristics and number) and their occurrence instants in each document. The model is widely applicable and is illustrated on datasets coming from multiple modalities, mainly videos from static cameras and audio localization data. The rich semantic interpretation that the model offers can be leveraged in tasks such as event counting or for scene analysis. The approach is also used as a mean of doing soft camera calibration in a camera network. A thorough study of the model parameters is provided and a cross-platform implementation of the inference algorithm will be made publicly available.
The enzymatic detoxification of the mycotoxin deoxynivalenol: identification of DepA from the DON epimerization pathway

The biological detoxification of mycotoxins, including deoxynivalenol (DON), represents a very promising approach to address the challenging problem of cereal grain contamination. The recent discovery of Devosia mutans 17‐2‐E‐8 (Devosia spp. 17‐2‐E‐8), a bacterial isolate capable of transforming DON to the non‐toxic stereoisomer 3‐epi‐deoxynivalenol, along with earlier reports of bacterial species capable of oxidizing DON to 3‐keto‐DON, has generated interest in the possible mechanism and enzyme(s) involved. An understanding of these details could pave the way for novel strategies to manage this widely present toxin. It was previously shown that DON epimerization proceeds through a two‐step biocatalysis. Significantly, this report describes the identification of the first enzymatic step in this pathway. The enzyme, a dehydrogenase responsible for the selective oxidation of DON at the C3 position, was shown to readily convert DON to 3‐keto‐DON, a less toxic intermediate in the DON epimerization pathway. Furthermore, this study provides insights into the PQQ dependence of the enzyme. This enzyme may be part of a feasible strategy for DON mitigation within the near future.
MuLTILINguAL RESOuRcES, TEcHNOLOgIES ANd EvALuATION fOR cENTRAL ANd EASTERN EuROPEAN LANguAgES

This paper discusses the building of the first Bulgarian– Polish–Lithuanian (for short, BG–PL–LT) experimental corpus. The BG–PL–LT corpus (currently under development only for research) contains more than 3 million words and comprises two corpora: parallel and comparable. The BG–PL– LT parallel corpus contains more than 1 million words. A small part of the parallel corpus comprises original texts in one of the three languages with translations in two others, and texts of official documents of the European Union available through the Internet. The texts (fiction) in other languages translated into Bulgarian, Polish, and Lithuanian form the main part of the parallel corpus. The comparable BG–PL–LT corpus includes: (1) texts in Bulgarian, Polish and Lithuanian with the text sizes being comparable across the three languages, mainly fiction, and (2) excerpts from E-media newspapers, distributed via Internet and with the same thematic content. Some of the texts have been annotated at paragraph level. This allows texts in all three languages and in pairs BG–PL, PL–LT, BG–LT, and vice versa to be aligned at paragraph level in order to produces aligned threeand bilingual corpora. The authors focused their attention on the morphosyntactic annotation of the parallel trilingual corpus, according to the Corpus Encoding Standard (CES). The tagsets for corpora annotation are briefly discussed from the point of view of possible unification in future. Some examples are presented.
The Effects of Vitamin D Supplement on Prevention of Recurrence of Preeclampsia in Pregnant Women with a History of Preeclampsia

Introduction Preeclampsia is a pregnancy-specific syndrome. One of the hypotheses concerning the etiology of preeclampsia is vitamin D deficiency during pregnancy. Method and Materials The present study is a randomized controlled clinical trial which aims to determine the effect of vitamin D supplement on reducing the probability of recurrent preeclampsia. 72 patients were placed in control group while 70 patients were randomized to the intervention group. The intervention group received a 50000 IU pearl vitamin D3 once every two weeks. The control group was administered placebo. Vitamin D or placebo was given until the 36th week of pregnancy. Results The patients in intervention group have significantly lower (P value = 0.036) probability of preeclampsia than patients in the control group. The risk of preeclampsia for the control group was 1.94 times higher than that for the intervention group (95% CI 1.02, 3.71). Conclusion The intended intervention (i.e., prescription of vitamin D) has a protective effect against recurrent preeclampsia. Vitamin D supplementation therapy in pregnancy could help in reducing the incidence of gestational hypertension/preeclampsia. Registration This study has been registered in Iranian Registry of Clinical Trials (IRCT) site with ID number IRCT2017010131695N1.
Optimizing throughput of power- and thermal-constrained multicore processors using DVFS and per-core power-gating

Process variability from a range of sources is growing as technology scales below 65nm, resulting in increasingly nonuniform transistor delay and leakage power both within a die and across dies. As a result, the negative impact of process variations on the maximum operating frequency and the total power consumption of a processor is expected to worsen. Meanwhile, manufacturers have integrated more cores in a single die, substantially improving the throughput of a processor running highly-parallel applications. However, many existing applications do not have high enough parallelism to exploit multiple cores in a die. In this paper, first, we analyze the throughput impact of applying per-core power gating and dynamic voltage and frequency scaling to power- and thermal-constrained multicore processors. To optimize the throughput of the multicore processors running applications with limited parallelism, we exploit power- and thermal-headroom resulted from power-gated idle cores, allowing active cores to increase operating frequency through supply voltage scaling. Our analysis using a 32nm predictive technology model shows that optimizing the number of active cores and operating frequency within power, thermal, and supply voltage scaling limits improves the throughput of a 16-core processor by ∼16%. Furthermore, we extend our throughput analysis and optimization to consider the impact of within-die process variations leading to core-to-core frequency (and leakage power) variations in a multicore processor. Our analysis shows that exploiting core-to-core frequency variations improves the throughput of a 16-core processor by ∼75%.
NAOSITE : Nagasaki University ' s Academic Output SITE

Background: In its effort to survive the human immune system, Plasmodium falciparum uses several parasite-derived antigens most of which are expressed at the surface of the parasitized red blood cells (pRBCs). Recently SURFINs, a new family of antigens encoded by the surf multi-gene family, has been reported. One member of the family, SURFIN4.2, was found present both at the pRBC-surface and at the merozoite apex. Methods: The presence of a second SURFIN member, SURFIN4.1 (PFD0100c, PFD0105c) is reported here. Bioinformatic tools were used to study the structure of the surf4.1 gene. To investigate the expression of surf genes PCR and real-time quantitative PCR (Rt-QPCR) were employed and Northern and Western blots were used to confirm the size of the surf4.1 gene and the SURFIN4.1 protein respectively. Localization of SURFIN4.1 was determined using immunofluorescence assays. Results: The surf4.1 gene was found present in one copy by Rt-QPCR in some parasites (3D7AH1, 3D7S8, 7G8) whereas six copies of the gene were identified in FCR3 and FCR3S1.2. surf4.1 was found transcribed in the late asexual stages of the parasite beginning ≈32 hours post invasion and throughout the schizont stages with the level of transcription peaking at late schizogony. The levels of transcript correlated with the number of gene copies in FCR3 and 3D7S8. surf4.1 was found to encode a polypeptide of ≈Mw 258 kDa (SURFIN4.1) present within the parasitophorous vacuole (PV), around free merozoites as merozoite-associated material, but not at the pRBC-surface. Despite multiple surf4.1 gene copies in some parasites this was not reflected in the levels of SURFIN4.1 polypeptide. Conclusion: SURFIN4.1 is a member of the SURFINs, present in the PV and on the released merozoite. The results suggest different SURFINs to be expressed at different locations in the parasite and at distinct time-points during the intra-erythrocytic cycle. Published: 1 July 2008 Malaria Journal 2008, 7:116 doi:10.1186/1475-2875-7-116 Received: 12 November 2007 Accepted: 1 July 2008 This article is available from: http://www.malariajournal. com/content/7/1/116 © 2008 Mphande et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Malaria Journal 2008, 7:116 http://www.malariajournal. com/content/7/1/116
Accelerated Echo-Planar J-Resolved Spectroscopic Imaging in the Human Brain Using Compressed Sensing: A Pilot Validation in Obstructive Sleep Apnea

BACKGROUND AND PURPOSE: Echo-planar J-resolved spectroscopic imaging is a fast spectroscopic technique to record the biochemical information in multiple regions of the brain, but for clinical applications, time is still a constraint. Investigations of neural injury in obstructive sleep apnea have revealed structural changes in the brain, but determining the neurochemical changes requires more detailed measurements across multiple brain regions, demonstrating a need for faster echo-planar J-resolved spectroscopic imaging. Hence, we have extended the compressed sensing reconstruction of prospectively undersampled 4D echo-planar J-resolved spectroscopic imaging to investigate metabolic changes in multiple brain locations of patients with obstructive sleep apnea and healthy controls. MATERIALS AND METHODS: Nonuniform undersampling was imposed along 1 spatial and 1 spectral dimension of 4D echo-planar J-resolved spectroscopic imaging, and test-retest reliability of the compressed sensing reconstruction of the nonuniform undersampling data was tested by using a brain phantom. In addition, 9 patients with obstructive sleep apnea and 11 healthy controls were investigated by using a 3T MR imaging/MR spectroscopy scanner. RESULTS: Significantly reduced metabolite differences were observed between patients with obstructive sleep apnea and healthy controls in multiple brain regions: NAA/Cr in the left hippocampus; total Cho/Cr and Glx/Cr in the right hippocampus; total NAA/Cr, taurine/Cr, scyllo-Inositol/Cr, phosphocholine/Cr, and total Cho/Cr in the occipital gray matter; total NAA/Cr and NAA/Cr in the medial frontal white matter; and taurine/Cr and total Cho/Cr in the left frontal white matter regions. CONCLUSIONS: The 4D echo-planar J-resolved spectroscopic imaging technique using the nonuniform undersampling–based acquisition and compressed sensing reconstruction in patients with obstructive sleep apnea and healthy brain is feasible in a clinically suitable time. In addition to brain metabolite changes previously reported by 1D MR spectroscopy, our results show changes of additional metabolites in patients with obstructive sleep apnea compared with healthy controls.