Miracle-dz/UniFAR-FTUs huggingface dataset:
Central effects of photoperiod on reproduction in the ram revealed by the use of a testosterone clamp.

Over a 3-year period eight adult Soay rams were exposed to an artificial lighting regimen of alternating 16-week periods of long days (16 h light: 8 h darkness; 16L : 8D) and short days (8L : 16D) to induce a seasonal cycle in reproduction and wool growth every 32 weeks. Early in the study the rams were castrated (four during long days and four during short days) and 48 weeks later the castrated animals were each given an s.c. implant of testosterone to increase the blood plasma concentration of testosterone to 14-20 nmol/l. The changes in the concentrations of LH, FSH and testosterone were measured in blood samples collected once or twice weekly while records were made of the changes in the size of the testes (before castration), the intensity of the sexual skin flush, the expression of aggressive and sexual behaviour and the rate of wool growth. The results showed that in the castrated rams there were only minor changes in the blood levels of LH, FSH and the expression of aggressive behaviour related to the 32-week light cycle, while the sexual skin flush was permanently absent. However, after the commencement of the constant testosterone therapy, there were major changes in all the reproductive parameters related to the lighting regimen with a similar temporal relationship as observed in the rams before castration. Cyclic variation in wool growth occurred throughout the study related to the changes in photoperiod but this was not markedly affected by castration and testosterone replacement. (ABSTRACT TRUNCATED AT 250 WORDS)
Single Input Fuzzy Control of Nonlinear and Time-Varying Plant

The aim of this paper is to design a single input PI fuzzy controller for a nonlinear and time-varying plant – the biogas production rate in the anaerobic digestion of organic waste in waste water treatment. The main contributions are the design of the SI FC, the study of the closed loop control system performance and the estimation of the advantages of the SI FC system in comparison to other systems with advanced fuzzy controllers. The single input fuzzy controller (SI FC) reduces the complexity in the design and the tuning of fuzzy controllers and ensures stability and high performance of the closed loop system. The investigation is based on Matlab, Simulink and Fuzzy Logic Toolbox. Key-Words: Single input PI fuzzy controller, simulation, anaerobic digestion of organic waste, stability, Matlab
The prevalence and significance of cannabis use in patients prescribed chronic opioid therapy: a review of the extant literature.

BACKGROUND Cannabis is the most widely consumed illicit drug in the United States. Its use, particularly in early initiates, is associated with subsequent development of other drug and alcohol use disorders. OBJECTIVE The authors examined the prevalence of cannabis use and the association between cannabis use and aberrant opioid-related behaviors in patients prescribed chronic opioid therapy for persistent pain. METHODS PubMed was queried for studies of chronic opioid therapy in which aberrant opioid-related behaviors were quantitatively examined and in which cannabis use data (as determined by cannabinoid-positive urine drug tests) were extricable from that of other substances of abuse. RESULTS The prevalence of cannabis use among patients prescribed chronic opioid therapy in these studies ranged from 6.2% to 39%, compared with 5.8% in the general United States population. Furthermore, cannabis use in chronic opioid patients shows statistically significant associations with present and future aberrant opioid-related behaviors. CONCLUSION Cannabis use is prevalent in patients prescribed chronic opioid therapy and is associated with opioid misuse. Further research is necessary to clarify the strength and the nature of the association between cannabis use and opioid misuse, and to address additional questions about the consequences of cannabis use in the context of chronic opioid therapy.
Effects of Angiotensin II on the Action Potential Durations of Atrial Myocytes in Hypertensive Rats

Angiotensin II (Ang II) has been reported to indirectly influence atrial electrical activity and to play a critical role in atrial arrhythmias in hypertensive patients. However, it is unclear whether Ang II has direct effects on the electrophysiological activity of the atrium affected by hypertension. We examined the effects of Ang II on the action potentials of atrial myocytes enzymatically isolated from spontaneous hypertensive rats (SHRs). The action potentials were recorded by the perforated patch-clamp technique and the atrial expression of the receptors AT1a and AT2 was measured by radioimmunoassay. Ang II significantly shortened the action potential durations (APDs) of SHRs without changes in the resting membrane potentials (RMPs). Pretreatment with selective AT1a blockers abolished the Ang II-induced reduction of atrial APDs of SHRs; however, a selective AT2 blocker did not, which was consistent with the results of the receptor assay. Pretreatment with phosphatidylinositol 3 (PI3)-kinase inhibitor, phospholipase C inhibitor, or protein kinase C (PKC) inhibitor abolished the Ang II-induced shortening of atrial APDs, but pertussis toxin and protein kinase A (PKA) inhibitor did not. To study the effects of chronic AT1a inhibition on Ang II-induced shortening of atrial APD, SHRs were treated with AT1a blocker for 4 weeks. AT1a blocker abolished the Ang II-induced reduction of atrial APDs of SHRs and also significantly lowered their blood pressure. In conclusion, Ang II shortened atrial APDs of SHRs via AT1a coupled with the Gq-mediated inositol triphosphate (IP3)-PKC pathway. Our findings indicated that Ang II caused atrial arrhythmias in hypertensive patients by shortening the effective refractory period of the atrium.
Trust Inference and Query Answering over Uncertain Information

On the Semantic Web, decision makers (humans or software agents alike) are faced with the challenge of examining large volumes of information originating from heterogeneous sources with the goal of ascertaining trust in various pieces of information. While previous work has focused on simple models for review and rating systems, we introduce a new trust model for rich, complex and uncertain information. We present the challenges raised by the new model, and solutions to support scalable trust-based query answering over uncertain information. An evaluation of the first prototype implementation under a variety of scenarios shows the robustness of our trust model, and the scalability of trust-based query answering over uncertain information.
Fungal Laccases and Their Applications in Bioremediation

Laccases are blue multicopper oxidases, which catalyze the monoelectronic oxidation of a broad spectrum of substrates, for example, ortho- and para-diphenols, polyphenols, aminophenols, and aromatic or aliphatic amines, coupled with a full, four-electron reduction of O2 to H2O. Hence, they are capable of degrading lignin and are present abundantly in many white-rot fungi. Laccases decolorize and detoxify the industrial effluents and help in wastewater treatment. They act on both phenolic and nonphenolic lignin-related compounds as well as highly recalcitrant environmental pollutants, and they can be effectively used in paper and pulp industries, textile industries, xenobiotic degradation, and bioremediation and act as biosensors. Recently, laccase has been applied to nanobiotechnology, which is an increasing research field, and catalyzes electron transfer reactions without additional cofactors. Several techniques have been developed for the immobilization of biomolecule such as micropatterning, self-assembled monolayer, and layer-by-layer techniques, which immobilize laccase and preserve their enzymatic activity. In this review, we describe the fungal source of laccases and their application in environment protection.
Economic globalisation, skill formation and the consequences for higher education

This collection brings together many of the world’s leading sociologists of education to explore and address key issues and concerns within the discipline. The chapters draw upon theory and research to provide new accounts of contemporary educational processes, global trends, and changing and enduring forms of social conflict and social inequality. The research, conducted by leading international scholars in the field, indicates that two complexly interrelated agendas are discernible in the heat and noise of educational change over the past 25 years. The first rests on a clear articulation by the state of its requirements of education. The second promotes at least the appearance of greater autonomy on the part of educational institutions in the delivery of those requirements. The Routledge International Handbook of the Sociology of Education examines the ways in which the sociology of education has responded to these two political agendas, addressing a range of issues which cover three key areas: Perspectives and Theories Social Processes and Practices Inequalities and Resistances The book strongly communicates the vibrancy and diversity of the sociology of education and the nature of ‘sociological work’ in this field. It will be a primary resource for teachers, as well as a title of major interest to practising sociologists of education.
Filling in versus finding out: A ubiquitous confusion in cognitive science

One of the things you learn if you read books and articles in (or about) cognitive science is that the brain does a lot of "filling in"--not filling in, but "filling in"--in scare quotes. My claim today will be that this way of talking is not a safe bit of shorthand, or an innocent bit of temporizing, but a source of deep confusion and error. The phenomena described in terms of "filling in" are real, surprising, and theoretically important, but it is a mistake to conceive of them as instances of something being filled in, for that vivid phrase always suggests too much--sometimes a little too much, but often a lot too much. Here are some examples (my boldface throughout).
New Package in Maxima for Single-Valued Interval Computation on Real Numbers

Intervals play a pivotal role in both theoretical mathematics and applied mathematics. As a consequence, interval computation is becoming increasingly used in several fields of Mathematics and other applied sciences. However, only a few computer programs include specialized tools and libraries for interval computation so far. In this paper we describe a new package for dealing with single-valued interval computation on real numbers. The package, developed by the authors in free ware program Maxima, version 5.23. 2, allows the user to manipulate single-valued real and extended intervals and carry out the most typical set operations on intervals (such as union, intersection and difference) in a smoothly and user-friendly way. The main features of our package are discussed throughout the paper. Several illustrative examples, aimed to show the good performance of the package, are also given.
Anterior Inferior Cerebellar Arteries Juxtaposed with the Internal Acoustic Meatus and Their Relationship to the Cranial Nerve VII/VIII Complex

Vascular loops in the cerebellopontine angle (CPA) and their relationship to cranial nerves have been used to explain neurological symptoms. The anterior inferior cerebellar artery (AICA) has variable branches producing vascular loops that can compress the facial cranial nerve (CN) VII and vestibulocochlear (CN VIII) nerves. AICA compression of the facial-vestibulocochlear nerve complex can lead to various clinical presentations, including hemifacial spasm (HFS), tinnitus, and hemiataxia. The formation of arterial loops inside or outside of the internal auditory meatus (IAM) can cause abutment or compression of CN VII and CN VIII. Twenty-five (50 sides) fresh adult cadavers underwent dissection of the cerebellopontine angle in the supine position. In regard to relationships between the AICA and the nerves of the facial/vestibulocochlear complex, 33 arteries (66%) traveled in a plane between the facial/nervus intermedius nerves and the cochlear and vestibular nerves. Five arteries (10%) traveled below the CN VII/VIII complex, six (12%) traveled posterior to the nerve complex, four (8%) formed a semi-circle around the upper half of the nerve complex, and two (4%) traveled between and partially separated the nervus intermedius and facial nerve proper. Our study found that the majority of AICA will travel in a plane between the facial/nervus intermedius nerves and the cochlear and vestibular nerves. Although the relationship between the AICA and porus acusticus and AICA and the nerves of the CN VII/VIII complex are variable, based on our findings, some themes exist. Surgeons should consider these with approaches to the cerebellopontine angle.
Interaoperative use of epidural methylprednisolone or bupivacaine for postsurgical lumbar discectomy pain relief: A randomized, placebo-controlled trial

BACKGROUND Many patients with lumbar disc surgery experience postoperative back and radicular pain, delaying hospital discharge and resumption of normal activity. Some surgeons have used intraoperative epidural corticosteroids and local anesthetics to decrease pain following surgery for a herniated lumbar disc. Controversies still exist regarding the benefits of these drugs. The present study was meant to compare the effects of the intraoperative administration of epidural methylprednisolone and bupivacaine with that of normal saline (placebo) in lumbar disc surgery for postoperative pain control. PATIENTS AND METHODS One hundred fifty patients with single level herniated nucleus pulposus (L4–L5 or L5–S1), which was refractory to 6 weeks of conservative management, were divided randomly in three groups. A standard hemipartial lamimectomy and discectomy was performed on all patients. At the end of the surgery, before the closure of fascia, 40 mg methylprednisolone with 3 mL normal saline for group 1, 2 mL bupivacaine 5% with 2 mL normal saline for group 2 and 4 mL normal saline for group 3 were instilled onto the epidural and exposed nerve root. Postoperative back and radicular pain intensity was assessed by a visual analogue scale (VAS) before and at 24, 48, 72, and 96 hours after surgery. RESULTS There was no significant difference in back and radicular pain intensity between the three groups. CONCLUSION Intraoperative administration of epidural methylprednisolone or bupivacaine does not relieve postoperative back and radicular pain.
Vermont Granite Mortality Study: An Update With an Emphasis on Lung Cancer

This mortality study extends the period of observation of an article published in 1988 1 of 5414 workers in Vermont granite sheds and quarries to assess whether previously reported reductions in silicosis and tuberculosis mortality were maintained. The relationship between lung cancer and quartz exposure is also examined by comparing mortality in workers hired before and after 1940, when dust controls were introduced and exposures were reduced by 80% to 90%. Before 1940, general stone shed air contained 20 million particles/cubic foot (mppcf) (approximately equivalent to 0.2 mg/m2 of quartz), and pneumatic chisel workers were exposed on average to 60 mppcf (approximately equivalent to 0.6 mg/m2 of quartz). Other workers had variable exposures. After 1940, a period of decline occurred in dust levels and then stabilized in approximately 1955, when average dust levels were 5 to 6 mppcf (equivalent to 0.05–.06 mg/m2 of quartz). Dust exposures in the Vermont industry is considered to be free of confounding occupational substances such as arsenic, although cigarette smoking was common. By the end of 1996, 2539 workers, or 46.9% of the cohort, had died. There were no silicosis deaths in workers hired after 1940 who were exposed only in the Vermont granite industry, illustrating the effect of lowering quartz exposures. Tuberculosis caused 2 deaths in those hired after 1940 (standardized mortality ratio [SMR] = 0.52; not significant). Overall lung cancer mortality was elevated in shed workers who had been exposed both to high levels of quartz before 1940 and to the lower levels prevailing after 1940 (SMR = 1.32; P < 0.01). Quarry workers did not show an excess of lung cancer (SMR = 0.73; not significant). When shed workers with high and low exposure histories (before and after 1940) but with comparable latency and tenure were contrasted, lung cancer mortality was similar. Differing levels of quartz exposure, which resulted in large differences in the mortality experience from silicosis, did not result in differences in lung cancer mortality. The results do not support the hypothesis that granite dust exposure has a causal association with lung cancer.
Relative Citation Ratio (RCR): An empirical attempt to study a new field‐normalized bibliometric indicator

Hutchins, Yuan, Anderson, and Santangelo (2015) proposed the Relative Citation Ratio (RCR) as a new field‐normalized impact indicator. This study investigates the RCR by correlating it on the level of single publications with established field‐normalized indicators and assessments of the publications by peers. We find that the RCR correlates highly with established field‐normalized indicators, but the correlation between RCR and peer assessments is only low to medium.
Turmeric improves post-prandial working memory in pre-diabetes independent of insulin.

BACKGROUND AND OBJECTIVES Cognitive impairment develops with pre-diabetes and dementia is a complication of diabetes. Natural products like turmeric and cinnamon may ameliorate the underlying pathogenesis. METHODS People ≥ 60 years (n=48) with newly-recognised untreated pre-diabetes were randomised to a double-blind metabolic study of placebo, turmeric (1 g), cinnamon (2 g) or both (1 g & 2 g respectively), ingested at a white bread (119 g) breakfast. Observations were made over 6 hours for pre- and post-working memory (WM), glycaemic and insulin responses and biomarkers of Alzheimer's disease (AD)(0, 2, 4 and 6 hours): amyloid precursor protein (APP), γ-secretase subunits presenilin-1 (PS1), presenilin-2 (PS2), and glycogen synthase kinase (GSK-3β). Differences between natural product users and non-users were determined by Students t and chi square tests; and between pre-test and post-test WM by Wilcoxon signed rank tests. Interaction between turmeric and cinnamon was tested by 2-way ANOVA. Multivariable linear regression (MLR) took account of BMI, glycaemia, insulin and AD biomarkers in the WM responses to turmeric and cinnamon. RESULTS No interaction between turmeric and cinnamon was detected. WM increased from 2.6 to 2.9 out of 3.0 (p=0.05) with turmeric, but was unchanged with cinnamon. WM improvement was inversely associated with insulin resistance (r=-0.418, p<0.01), but not with AD biomarkers. With MLR, the WM responses to turmeric were best predicted with an R2 of 34.5%; and with significant turmeric, BMI and insulin/glucose AUC beta-coefficients. CONCLUSIONS Co-ingestion of turmeric with white bread increases working memory independent of body fatness, glycaemia, insulin, or AD biomarkers.
Transient NMDA receptor‐mediated hypoperfusion following umbilical cord occlusion in preterm fetal sheep

Exposure to severe hypoxia leads to delayed cerebral and peripheral hypoperfusion. There is evidence in the very immature brain that transient abnormal glutaminergic receptor activity can occur during this phase of recovery. We therefore examined the role of N‐methyl‐d‐aspartate (NMDA) receptor activity in mediating secondary hypoperfusion in preterm fetal sheep at 70% of gestation. Fetuses received either sham asphyxia or asphyxia and were studied for 12 h recovery. The specific, non‐competitive NMDA receptor antagonist dizocilpine maleate (2 mg kg−1 bolus plus 0.07 mg kg h−1i.v.) or saline (vehicle) was infused from 15 min after asphyxia until 4 h. In the asphyxia–vehicle group abnormal epileptiform EEG transients were observed during the first 4 h of reperfusion, the peak of which corresponded approximately to the nadir in peripheral and cerebral hypoperfusion. Dizocilpine significantly suppressed this activity (2.7 ± 1.3 versus 11.2 ± 2.7 counts min−1 at peak frequency, P < 0.05) and markedly delayed and attenuated the rise in vascular resistance in both peripheral and cerebral vascular beds observed after asphyxia, effectively preventing the initial deep period of hypoperfusion in carotid blood flow and femoral blood flow (P < 0.01). However, while continued infusion did attenuate subsequent transient tachycardia, it did not prevent the development of a secondary phase of persistent but less profound hypoperfusion. In conclusion, the present studies suggest that in the immature brain the initial phase of delayed cerebral and peripheral hypoperfusion following exposure to severe hypoxia is mediated by NMDA receptor activity. The timing of this effect in the cerebral circulation corresponds closely to abnormal EEG activity, suggesting a pathological glutaminergic activation that we speculate is related to evolving brain injury.
Node Clustering in Graphs: An Empirical Study

Modeling networks is an active area of research and is used for many applications ranging from bioinformatics to social network analysis. An important operation that is often performed in the course of graph analysis is node clustering. Popular methods for node clustering such as the normalized cut method have their roots in graph partition optimization and spectral graph theory. Recently, there has been increasing interest in modeling graphs probabilistically using stochastic block models and other approaches that extend it. In this paper, we present an empirical study that compares the node clustering performances of state-of-the-art algorithms from both the probabilistic and spectral families on undirected graphs. Our experiments show that no family dominates over the other and that network characteristics play a significant role in determining the best model to use.
Parallelized Kendall's Tau Coefficient Computation via SIMD Vectorized Sorting On Many-Integrated-Core Processors

Pairwise association measure is an important operation in data analytics. Kendall's tau coefficient is one widely used correlation coefficient identifying non-linear relationships between ordinal variables. In this paper, we investigated a parallel algorithm accelerating all-pairs Kendall's tau coefficient computation via single instruction multiple data (SIMD) vectorized sorting on Intel Xeon Phis by taking advantage of many processing cores and 512-bit SIMD vector instructions. To facilitate workload balancing and overcome on-chip memory limitation, we proposed a generic framework for symmetric all-pairs computation by building provable bijective functions between job identifier and coordinate space. Performance evaluation demonstrated that our algorithm on one 5110P Phi achieves two orders-of-magnitude speedups over 16-threaded MATLAB and three orders-of-magnitude speedups over sequential R, both running on high-end CPUs. Besides, our algorithm exhibited rather good distributed computing scalability with respect to number of Phis. Source code and datasets are publicly available at this http URL.