Miracle-dz/UniFAR-FTUs huggingface dataset:
Mathematical models and simulations of different scenarios of COVID-19 in Brazil

In this paper, we develop successive mathematical models for describing the first and second waves of COVID-19 in Brazil, including the origi[1]nal strain, the two variants with the highest circulation (Gamma and Delta variants) and population vaccination. We started with a a simple initial model and using mathematical modelling techniques and the Heaviside step function, we improved it according to the necessities of describing the disease’s behaviour, both considering the new variants or vaccination. In all cases, we performed computer simulations and compared the obtained curve with real data from the active cases, which reinforced the model’s efficiency in describing the behaviour of the pandemic and highlighted the importance of population vaccination in describing the dynam[1]ics of the infections and reducing cases.
Combining Phenylalanine and Leucine Levels Predicts 30-Day Mortality in Critically Ill Patients Better than Traditional Risk Factors with Multicenter Validation

In critically ill patients, risk scores are used; however, they do not provide information for nutritional intervention. This study combined the levels of phenylalanine and leucine amino acids (PLA) to improve 30-day mortality prediction in intensive care unit (ICU) patients and to see whether PLA could help interpret the nutritional phases of critical illness. We recruited 676 patients with APACHE II scores ≥ 15 or intubated due to respiratory failure in ICUs, including 537 and 139 patients in the initiation and validation (multicenter) cohorts, respectively. In the initiation cohort, phenylalanine ≥ 88.5 μM (indicating metabolic disturbance) and leucine < 68.9 μM (indicating malnutrition) were associated with higher mortality rate. Based on different levels of phenylalanine and leucine, we developed PLA scores. In different models of multivariable analyses, PLA scores predicted 30-day mortality independent of traditional risk scores (p < 0.001). PLA scores were then classified into low, intermediate, high, and very-high risk categories with observed mortality rates of 9.0%, 23.8%, 45.6%, and 81.8%, respectively. These findings were validated in the multicenter cohort. PLA scores predicted 30-day mortality better than APACHE II and NUTRIC scores and provide a basis for future studies to determine whether PLA-guided nutritional intervention improves the outcomes of patients in ICUs.
Akkermansia muciniphila Alleviates Persistent Inflammation, Immunosuppression, and Catabolism Syndrome in Mice

Many patients in intensive care units, especially the elderly, suffer from chronic critical illness and exhibit a new pathophysiological phenotype: persistent inflammation, immunosuppression, and catabolism syndrome (PICS). Most patients with PICS have a constellation of digestive-system symptoms and gut failure. Akkermansia muciniphila (Akk) is a commensal gut bacterium that reduces inflammation, balances immune responses, modulates energy metabolism, and supports gut health. This study investigated the protective effects and underlying mechanisms of live and pasteurized Akk in treating PICS in a mouse model. PICS was induced on day 14 after performing cecal ligation and puncture (CLP) on day 1 and administrating lipopolysaccharide on day 11. Pasteurized or live Akk, or phosphate-buffered saline was administered twice daily by oral gavage for 7 days. Both live and pasteurized Akk attenuated PICS, as evidenced by reduced weight loss, and a reduction in symptoms and serum cytokine/chemokine levels. Liver and intestinal injuries were mitigated, and intestinal barrier integrity improved with Akk administration. Analysis of 16S rRNA amplicon sequences showed that Akk induced significant intestinal microbiota alterations, including increased abundance of Akk, Muribaculaceae, Parabacterbides goldsteinii, and decreased abundance of Escherichia_Shigella and Enterobacteriaceae. Collectively, Akk alleviates PICS by enhancing gut barrier function and reshaped the microbial community.
Global Functional Connectivity at Rest Is Associated with Attention: An Arterial Spin Labeling Study

Neural markers of attention, including those frequently linked to the event-related potential P3 (P300) or P3b component, vary widely within and across participants. Understanding the neural mechanisms of attention that contribute to the P3 is crucial for better understanding attention-related brain disorders. All ten participants were scanned twice with a resting-state PCASL perfusion MRI and an ERP with a visual oddball task to measure brain resting-state functional connectivity (rsFC) and P3 parameters (P3 amplitudes and P3 latencies). Global rsFC (average rsFC across the entire brain) was associated with both P3 amplitudes (r = 0.57, p = 0.011) and P3 onset latencies (r = −0.56, p = 0.012). The observed P3 parameters were correlated with predicted P3 amplitude from the global rsFC (amplitude: r = +0.48, p = 0.037; latency: r = +0.40, p = 0.088) but not correlated with the rsFC over the most significant individual edge. P3 onset latency was primarily related to long-range connections between the prefrontal and parietal/limbic regions, while P3 amplitudes were related to connections between prefrontal and parietal/occipital, between sensorimotor and subcortical, and between limbic/subcortical and parietal/occipital regions. These results demonstrated the power of resting-state PCASL and P3 correlation with brain global functional connectivity.
Novel Uncertainty Propagation Method for Robust Aerodynamic Design

Starting from a comparative study of various methods for uncertainty propagation, this paper presents a novel reduced quadrature technique to be used in gradient-based robust design optimization of aerodynamic shapes. The accuracy and computational efficiency of the method are investigated by means of mathematical analyses and numerical examples. The method is then applied to the robust design of airfoils under probabilistic uncertainty. It is shown that the solutions obtained through the proposed method can outperform those obtained through linearization, without any significant increase in computational cost.
A Multiple Ant Colony System for the Electric Vehicle Routing Problem with Time Windows

Ant colony optimization (ACO) has been found to be useful on several vehicle routing problem variations. In this work, ACO is applied to the electric vehicle routing problem with time windows (E-VRPTW). The E-VRPTW has a hierarchical multiple objective function, which is to minimize the number of electric vehicles and the total distance traveled. A multiple ACO is applied to E-VRPTW in which two colonies cooperate to minimize the objectives in parallel. A local search is embedded in ACO to improve the quality of the output. The experimental results on a set of benchmark instances show that the multiple ACO is competitive with existing methods.
‘It’s like Taking a Sleeping Pill’: Student Experience of Autonomous Sensory Meridian Response (ASMR) to Promote Health and Mental Wellbeing

Autonomous Sensory Meridian Response (ASMR) is purposely elicited by some individuals to promote health and mental wellbeing. The aim of the current study was to explore how ASMR is used and its perceived benefits in a student population. We employed semi-structured qualitative interviews, with eight female students who self-reported as ASMR-sensitive users. Inductive thematic analysis, underpinned by a phenomenological framework, was applied to the data. Two themes, each with three subthemes, were identified; these highlighted the journey from first discovering ASMR to present experience and the use of ASMR to promote health and mental wellbeing both directly and indirectly. For some, ASMR was used daily, whilst for others it was used in a relapsing-remitting fashion: usage increased when struggling with mental wellbeing and was most often used as a tool to induce sleep or distraction when feeling anxious. Participants also reported ASMR-eliciting content as intriguing, and that the phenomenon was regarded as taboo. ASMR appears to play an important role in promoting health and mental wellbeing; frequency of use, preferred triggers, and purpose of use varied, highlighting its flexible and subjective nature. It provides a potential cost-effective tool in populations such as students where mental health needs are burgeoning.
X-Ray Spectral Properties of Hot Gas Cavities around NGC 4636

A Chandra observation of NGC 4636 revealed that X-ray hot gas is violently disturbed. We investigated the detailed distributions of the temperature and absorption of hot gas, in order to derive information about the gas dynamics. The temperature gradually increases from 0.6keV at the center to 0.78keV at 2arcmin of the galaxy center; this is consistent with previous measurements. On the other hand, the azimuthal profiles of the temperature and absorption strongly correlate with the disturbance of hot gas. The west part, at 80arcsec from the galaxy center, exhibits a higher temperature by 0.1–0.2keV and an excess absorption by ∼ 5 × 10 20 cm −2 compared with the azimuthal averages. This unusual region corresponds to the western X-ray cavity with a size of 20arcsec radius. The same behavior is also seen around the northeast cavity with a smaller size than the west part. It is suggested that these unusual regions were caused by dramatic outflow or jet from the galactic nuclei, considering the east–west symmetry. The outflow gas or jet might have disturbed the surrounding hot gas and created hole-like regions. The observed high temperature and excess absorption of unusual regions indicate that the rims of holes might have been compressed, heated, and then cooled down at the end stage. We also discuss the past possible nuclear activity in NGC 4636.
Existence of a Periodic Solution for Some Partial Functional Differential Equations with Infinite Delay

Abstract This paper deals with the existence of periodic solutions for some partial functional differential equations with infinite delay. We suppose that the linear part is nondensely defined and satisfies the Hille–Yosida condition. In the nonlinear case we give several criteria to ensure the existence of a periodic solution. In the nonhomogeneous linear case, we prove the existence of a periodic solution under the existence of a bounded solution.
Gigahertz range electromagnetic wave absorbers made of amorphous-carbon-based magnetic nanocomposites

Nanocomposite magnetic materials α-Fe∕C(a), Fe2B∕C(a), and Fe1.4Co0. 6B∕C(a) were prepared by mechanically grinding α-Fe, Fe2B, or Fe1.4Co0. 6B with amorphous carbon [C(a)] powders. Complex permittivity, permeability, and electromagnetic wave absorption properties of resin compacts containing 40-vol% composite powders of α-Fe∕C(a), Fe2B∕C(a), and Fe1.4Co0. 6B∕C(a) were characterized according to a conventional reflection/transmission technique. The real part (er′) and imaginary part (er″) of the relative permittivity are low and almost independent of frequency between 0.05 and 40GHz. The Imaginary part (μr″) of the relative permeability exhibited wide peaks in the 1–9-GHz range for α-Fe∕C(a), in the 2–18-GHz range for Fe2B∕C(a), and in the 18–40-GHz range for Fe1.4Co0. 6B∕C(a) owing to their different magnetocrystalline anisotropy field (HA) values. Consequently, the resin compacts of 40-vol% α-Fe∕C(a), Fe2B∕C(a), and Fe1.4Co0. 6B∕C(a) powders provided good electromagnetic (em) wave absorption performances (re.
Infrared emission line studies of the structure and excitation of H II regions

Maps of five H II regions in one or more of the infrared fine-structure lines of Ne II (12.8 microns), Ar III (9.0 microns), and S IV (10.5 microns) have been obtained with angular resolutions ranging from 4 to 7 arcsec. The observations are used to discuss the morphology and excitation of these nebulae. Considerable diversity is found in the structures of the nebulae, probably resulting from differences in their ages and the circumstances of their formation. In all cases, more ionizing luminosity than would be provided by a single dominant ionizing star appears to be required, although uncertainties in the model nebulae make this conclusion uncertain.
A Comprehensive Review with Future Insights on the Processing and Safety of Fermented Fish and the Associated Changes

As an easily spoiled source of valuable proteins and lipids, fish is preserved by fermentation in many cultures. Over time, diverse types of products have been produced from fish fermentation aside from whole fish, such as fermented fish paste and sauces. The consumption of fermented fish products has been shown to improve both physical and mental health due to the composition of the products. Fermented fish products can be dried prior to the fermentation process and include various additives to enhance the flavours and aid in fermentation. At the same time, the fermentation process and its conditions play a major role in determining the quality and safety of the product as the compositions change biochemically throughout fermentation. Additionally, the necessity of certain microorganisms and challenges in avoiding harmful microbes are reviewed to further optimise fermentation conditions in the future. Although several advanced technologies have emerged to produce better quality products and easier processes, the diversity of processes, ingredients, and products of fermented fish warrants further study, especially for the sake of the consumers’ health and safety. In this review, the nutritional, microbial, and sensory characteristics of fermented fish are explored to better understand the health benefits along with the safety challenges introduced by fermented fish products. An exploratory approach of the published literature was conducted to achieve the purpose of this review using numerous books and online databases, including Google Scholar, Web of Science, Scopus, ScienceDirect, and PubMed Central, with the goal of obtaining, compiling, and reconstructing information on a variety of fundamental aspects of fish fermentation. This review explores significant information from all available library databases from 1950 to 2022. This review can assist food industries involved in fermented fish commercialization to efficiently ferment and produce better quality products by easing the fermentation process without risking the health and safety of consumers.
Determining the Authenticity of Spirulina Dietary Supplements Based on Stable Isotope and Elemental Composition

While the demand for Spirulina dietary supplements continues to grow, product inspection in terms of authenticity and safety remains limited. This study used the stable isotope ratios of light elements (C, N, S, H, and O) and the elemental composition to characterize Spirulina dietary supplements available on the Slovenian market. Forty-six samples were labelled as originating from the EU (1), non-EU (6), Hawaii (2), Italy (2), Japan (1), Portugal (2), Taiwan (3), India (4), and China (16), and nine products were without a declared origin. Stable isotope ratio median values were –23.9‰ (–26.0 to –21.8‰) for δ13C, 4.80‰ (1.30–8.02‰) for δ15N, 11.0‰ (6.79–12.7‰) for δ34S, –173‰ (– 190 to –158‰) for δ2H, and 17.2‰ (15.8–18.8‰) for δ18O. Multivariate statistical analyses achieved a reliable differentiation of Hawaiian, Italian, and Portuguese (100%) samples and a good separation of Chinese samples, while the separation of Indian and Taiwanese samples was less successful, but still notable. The study showed that differences in isotopic and elemental composition are indicative of sample origins, cultivation and processing methods, and environmental conditions such that, when combined, they provide a promising tool for determining the authenticity of Spirulina products.
Insights into the Sulfate Transporter Gene Family and Its Expression Patterns in Durum Wheat Seedlings under Salinity

Sulfate transporters (SULTRs) are an essential plant transporter class responsible for the absorption and distribution of sulfur, an essential plant growth element. SULTRs are also involved in processes related to growth and development and in response to environmental stimuli. In the present study, 22 TdSULTR family members were identified and characterized in the genome of Triticum turgidum L. ssp. durum (Desf.) using available bioinformatics tools. The expression levels of candidate TdSULTR genes were investigated under salt treatments of 150 and 250 mM NaCl after several different exposure times. TdSULTRs showed diversity in terms of physiochemical properties, gene structure, and pocket sites. TdSULTRs and their orthologues were classified into the known five main plant groups of highly diverse subfamilies. In addition, it was noted that segmental duplication events could lengthen TdSULTR family members under evolutionary processes. Based on pocket site analysis, the amino acids leucine (L), valine (V), and serine (S) were most often detected in TdSULTR protein binding sites. Moreover, it was predicted that TdSULTRs have a high potential to be targeted by phosphorylation modifications. According to promoter site analysis, the plant bioregulators ABA and MeJA were predicted to affect TdSULTR expression patterns. Real-time PCR analysis revealed TdSULTR genes are differentially expressed at 150 mM NaCl but show similar expression in response to 250 mM NaCl. TdSULTR reached a maximum level of expression 72 h after the 250 mM salt treatment. Overall, we conclude that TdSULTR genes are involved in the response to salinity in durum wheat. However, additional studies of functionality are needed to determine their precise function and linked-interaction pathways.
Interestingness is in the eye of the beholder – the impact of formative assessment on students’ situational interest in chemistry classrooms

ABSTRACT Students’ interest is considered an important learning outcome, but it is also a relevant predictor for student learning, and future vocational choices. According to numerous studies, however, students’ interest in STEM fields usually declines during the course of secondary education. From the perspective of science education, it is therefore necessary to foster or at least maintain students’ interest. Despite the variety of approaches that have already been examined in order to promote student interest, the problem of low-interested students remains. Prior findings indicate that specific person characteristics and the students’ perception of the situation seem to be moderate the effectiveness of many approaches. The current intensive repeated measure intervention study addresses the investigation of a possible interest trigger (formative assessment) and also the process that influences the perception of this trigger. Based on a sample of 9th-grade chemistry students (N = 200), three different interventions of formative assessment were implemented in regular classrooms. Students’ situational interest was assessed repeatedly in short time intervals. Based on multilevel analyses, not all interventions were perceived as equally interesting by the students. While students’ individual interest influences the perception of all interventions positively, the impact of gender, chemistry grade, and enjoyment varies across the interventions.
Pesticide Residues and Effect of Household Processing in Commonly Consumed Vegetables in Jimma Zone, Southwest Ethiopia

The long-term and indiscriminate use of pesticides has resulted in serious health effects. Aside from that, developing countries do not have any monitoring systems in place to prevent the consumption of high levels of pesticides in foods. Therefore, this study aimed to determine pesticide residues and the effect of processing in commonly consumed vegetables in the southwestern part of Ethiopia. In total, 12 samples of 1 kg of each type of vegetable were collected from selected markets. Moreover, as a solution to pesticide residue problems in vegetables, the effect of different processing methods such as washing, peeling, boiling, and their cumulative effect was studied. In the analytical procedure, the modified Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) extraction with florisil as a cleanup sorbent was used and the identification of pesticides was done by using gas chromatography with an electron capture detector (GC-ECD). The parent p,p'-DDT was detected at a concentration of 0.015 mg/kg in potato samples from the Serbo market and a concentration of 0.516, 0.232, 0.174, and 1.512 mg/kg in Merkato, Kochi, Serbo, and Shebe onion samples, respectively. P`p-DDT is detected at a high concentration compared to its metabolites (p,p'-DDE and p,p'-DDD), which is an indication of recent use. DDT and its metabolites, other organochlorines (lindane, γ-chlordane, dimethachlor, and heptachlor), and pyrethroids (cypermethrin and deltamethrin) exceeded the recommended limits by FAO and WHO in multiple samples of potato, onion, and cabbage. The processing result showed that washing, boiling, and the combination of the two revealed a 100% reduction in o,p'-DDT, and p,p'-DDT pesticides detected in cabbage. In conclusion, multiple residues were detected in the three vegetables studied, indicating that pesticides were applied intensively. Pesticide levels were reduced by home processing procedures, which is important for consumer safety.
Vision-Based Navigation Techniques for Unmanned Aerial Vehicles: Review and Challenges

In recent years, unmanned aerial vehicles (UAVs), commonly known as drones, have gained increasing interest in both academia and industries. The evolution of UAV technologies, such as artificial intelligence, component miniaturization, and computer vision, has decreased their cost and increased availability for diverse applications and services. Remarkably, the integration of computer vision with UAVs provides cutting-edge technology for visual navigation, localization, and obstacle avoidance, making them capable of autonomous operations. However, their limited capacity for autonomous navigation makes them unsuitable for global positioning system (GPS)-blind environments. Recently, vision-based approaches that use cheaper and more flexible visual sensors have shown considerable advantages in UAV navigation owing to the rapid development of computer vision. Visual localization and mapping, obstacle avoidance, and path planning are essential components of visual navigation. The goal of this study was to provide a comprehensive review of vision-based UAV navigation techniques. Existing techniques have been categorized and extensively reviewed with regard to their capabilities and characteristics. Then, they are qualitatively compared in terms of various aspects. We have also discussed open issues and research challenges in the design and implementation of vision-based navigation techniques for UAVs.