Miracle-dz/UniFAR-FTUs huggingface dataset:
Patient Interest in Sharing Personal Health Record Information

BACKGROUND Electronic personal health record (PHR) systems are proliferating but largely have not realized their potential for enhancing communication among patients and their network of care providers. OBJECTIVE To explore preferences about sharing electronic health information among users of the U.S. Department of Veterans Affairs (VA) PHR system, My HealtheVet. DESIGN Web-based survey of a convenience sample. SETTING My HealtheVet Web site from 7 July through 4 October 2010. PARTICIPANTS 18 471 users of My HealtheVet. MEASUREMENTS Interest in shared PHR access and preferences about who would receive access, the information that would be shared, and the activities that users would delegate. RESULTS Survey respondents were predominantly men (92%) and aged 50 to 64 years (51%) or 65 years or older (39%); approximately 39% reported poor or fair health status. Almost 4 of 5 respondents (79%) were interested in sharing access to their PHR with someone outside of their health system (62% with a spouse or partner, 23% with a child, 15% with another family member, and 25% with a non-VA health care provider). Among those who selected a family member other than a spouse or partner, 47% lived apart from the specified person. Preferences about degree of access varied on the basis of the type of information being shared, the type of activity being performed, and the respondent's relationship with the selected person. LIMITATIONS The survey completion rate was 40.8%. Results might not be generalizable to all My HealtheVet users. CONCLUSION In a large survey of PHR users in the VA system, most respondents were interested in sharing access to their electronic health information with caregivers and non-VA providers. Existing and evolving PHR systems should explore secure mechanisms for shared PHR access to improve information exchange among patients and the multiple persons involved in their health care. PRIMARY FUNDING SOURCE Veterans Health Administration and The Robert Wood Johnson Foundation Clinical Scholars Program.
MTAPIN: multi-touch key input enhances security of PIN authentication while keeping usability

Purpose – The aim of the research is to realize a better form of personal identification number (PIN) authentication for a mobile phone without lowering usability and acceptability. Design/methodology/approach – The authors’ approach is to extend the input operation of PIN authentication by allowing more than one number at a time using a multi-touch-enabled screen. The authors also introduced substitution keys to be able to type any combination of a PIN value and an input pattern by multi-touch typing. Findings – The authors conducted a user evaluation study using a Web-based prototype system. The results of the study indicate that PIN input time, input errors and secret memorability of the proposed scheme were no worse than those of conventional PIN authentication. The theoretical security level of the proposed scheme is almost three and a half times than that of the conventional scheme. Originality/value – The paper introduced a multi-touch-allowed secret input operation into a PIN authentication. Thoug.
Incremental Distributed Learning with JavaScript Agents for Earthquake and Disaster Monitoring

Ubiquitous computing and The Internet-of-Things (IoT) grow rapidly in today's life and evolving to Self-organizing systems (SoS). A unified and scalable information processing and communication methodology is required. In this work, mobile agents are used to merge the IoT with Mobile and Cloud environments seamless. A portable and scalable Agent Processing Platform (APP) provides an enabling technology that is central for the deployment of Multi-Agent Systems (MAS) in strong heterogeneous networks including the Internet. A large-scale use-case deploying Multi-agent systems in a distributed heterogeneous seismic sensor and geodetic network is used to demonstrate the suitability of the MAS and platform approach. The MAS is used for earthquake monitoring based on a new incremental distributed learning algorithm applied to seismic station data, which can be extended by ubiquitous sensing devices like smart phones. Different (mobile) agents perform sensor sensing, aggregation, local learning and prediction, global voting and decision making, and the application.
The Influence of Hemolysis, Turbidity and Icterus on the Measurements of CK-MB, Troponin I and Myoglobin

Abstract To decide on the acceptability of a specimen for the measurement of serum CK-MB, troponin I and myoglobin, we investigated the influence of hemolysis, turbidity, and icterus on those tests by adding arbitrarily made interferents. A total of 16 cases each for CK-MB and troponin I, and 18 cases for myoglobin tests were studied to verify the effects of hemolysis, turbidity, and unconjugated hyperbilirubinemia. A total of 16 cases were studied to clarify the effects of the conjugated hyperbilirubinemia. We graded the severity of hemolysis, turbidity, and icterus as mild, moderate, and severe after adding hemolysate, Intralipos (20% soybean oil), and unconjugated or conjugated bilirubin to sera. ACS180SE automated chemiluminescence system was used to measure CK-MB, troponin I, and myoglobin. CK-MB and troponin I were affected by any degree of hemolysis, turbidity, unconjugated hyperbilirubinemia, and conjugated hyperbilirubinemia, while myoglobin was affected only by severe unconjugated hyperbilirubinemia and conjugated hyperbilirubinemia in the samples with concentration higher than reference range, resulting in concentration level lower than baseline. In conclusion, the results of cardiac markers should be carefully interpreted when the specimens are hemolyzed, turbid or icteric.
Hybrid high-frequency-SiC and line-frequency-Si based PEBB for MV modular power converters

A phase-shift isolated DC-DC converters are expected to be the key elements of modern medium voltage (MV) modular power converters. By comparing to the conventional MV modular power converters including bulky line-frequency transformers, the isolated DC-DC converters enable significant volume reduction and flexible bidirectional power flow control. The isolated phase-shift DC-DC converter with integrated gate drivers and interface module can be recognized as the power electronics building block (PEBB). The present paper further extends the concept of PEBBs dedicated for MV modular power converters. A hybrid high-frequency SiC- and line-frequency Si-based isolated AC-DC-DC PEBB is proposed in the paper. It provides galvanic isolation, voltage transformation capability and requires fewer transistors and diodes than multistage multilevel H-bridge AC-DC-DC converter with the same number of voltage levels. Experimental results of the SiC-based phase shift DC-DC converter and simulation results of the proposed AC-DC-DC PEBB are presented to confirm the validity of the system.
A Proposed Number System for the 107 Cortical Areas of Economo and Koskinas, and Brodmann Area Correlations

In their Atlas of Cytoarchitectonics of the Adult Human Cerebral Cortex, Economo and Koskinas defined 54 ‘ground,’ 76 ‘variant,’ and 107 ‘modification’ areas. The 107 modifications are topographically distributed as 35 frontal, 13 superior limbic, 6 insular, 18 parietal, 7 occipital, 14 temporal and 14 inferior limbic (or hippocampal). One way to make the Economo-Koskinas system more practical is to encode the complex symbol notations of the 107 cortical areas with numbers EK 1 through EK 107. The present study does that, and it further correlates Economo-Koskinas areas with Brodmann areas, based on an overview of the classical and modern neurohistological literature.
A Coordenação das Políticas Fiscal e Monetária Ótimas

The potential gains of the optimal fiscal and monetary policy coordination are analyzed in a sticky price dynamic model. The public expenditure and the welfare function are derived from the microfoudations. We find the optimal rules in the case of coordination and with exogenous fiscal policy. The potential gain of coordination is estimated with a calibrated model. We made a study of the sensitiveness of the power of fiscal policy in the optimal rule and the welfare gain. The potential gain of coordination is about 6% of welfare. JEL Classification: E43, E52, E61, E62. Palavras-chaves: Politica Fiscal Otima, Politica Monetaria Otima, Coordenacao de Politicas.
A general probability-forecasting framework for final product quality of complex processes

There are several complex processes in the whole production cycle of some industrial products. Usually these complex processes require complicated production technics since the products cannot be processed in a batch manner. In this sense, it is difficult to control the ratio of each final quality level. To eliminate this effect in predicting the final quality level of products with several complex processes, a general probability-forecasting framework is proposed based on the support vector machine (SVM) model. In our framework, we first develop a model for SVM classification based on a two-phase heuristic method improved for SVM parameter optimization, and then an online probabilistic prediction model of each final quality level and a cost analysis scheme are presented respectively. Based on the proposed framework, our simulation experiment demonstrates the effectiveness of the improved SVM model in predicting the probabilities of final quality level of multi-processes and reducing the production cost of the whole process.
The relationship between poor growth rate and increased risk of Type 2 diabetes, insulin resistance and obesity

Type 2 diabetes, obesity and the metabolic syndrome are rapidly escalating in progressively younger individuals, leading to increased mortality, morbidity and healthcare costs. Research into preventing as well as treating these conditions is of the utmost importance. The link between low birth weight and the subsequent increased risk of developing Type 2 diabetes and obesity, as well as other features of the metabolic syndrome such as hypertension, is well established. This review discusses the evidence from both epidemiological studies and animal models supporting this link, as well as potential mechanisms. More recently, increasing focus has been on the detrimental effect of rapid postnatal growth after poor fetal growth. Improving prenatal nutrition and maintaining a steady and appropriate growth rate in early life could dramatically decrease the rates of Type 2 diabetes, obesity and other metabolic complications. Individuals who are at high risk because of their fetal and prenatal growth could, if informed, be able to make improved life choices. A combination of improved fetal and early-life nutrition and appropriate risk management for high-risk individuals could reduce the huge clinical burden of these conditions. This review will focus on the evidence suggesting a link between fetal and early-life growth and the risk of developing Type 2 diabetes, obesity and other factors of the metabolic syndrome in adult life. This evidence exists from a wide range of epidemiological studies as well as from a variety of animal models. Interventions both during pregnancy and early life as well as informed life choices in those at risk could dramatically reduce the huge clinical burden of obesity and its comorbidities.
Role of Microscopic Tissue Structure in Shock‐Induced Activation Assessed by Optical Mapping in Myocyte Cultures

Introduction: Termination of ventricular fibrillation by electric shocks is believed to be due to the direct activation of large tissue mass that may be caused by microscopic virtual electrodes formed at discontinuities in tissue structure. Here, microscopic shock‐induced activation was measured optically in myocyte cultures; spatially averaged microscopic Vm measurements were compared with macroscopic measurements from left ventricular (LV) tissue.
Behavior of transition metals in the structuring of nanostructures

Abstract The mixed oxides of SiO2–TiO2, MoO3–SiO2–TiO2, CoO–SiO2–TiO2 and MoO3–CoO–SiO2–TiO2 are prepared from a stable homogeneous mixture based on transition metals. During the preparation, it is necessary to know the duration of the stability of this solution, to control its stability, use the Zetasizer. The sol-gel process is one of the most widely used synthetic methods. This leads to the formation of homogeneous products. In present study; the structure, composition, particle size, morphology and porosity of the particles are obtained. The nanostructured mixed oxides has been characterized by physico-chemical analysis methods, including Acidity, Zeta potential, FTIR, BET, X-ray diffraction and TEM.
Contact-dependent Growth Inhibition and Apoptosis of Epidermal Growth Factor (EGF) Receptor-expressing Cells by the Membrane-anchored Form of Heparin-binding EGF-like Growth Factor*

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) transduces mitogenic signals through the EGF receptor (EGFR). There are two forms of HB-EGF, the membrane-anchored form (pro-HB-EGF) and the soluble form (sHB-EGF). We studied the biological activity of pro-HB-EGF by using a model in which pro-HB-EGF-expressing effector cells was co-cultured with EGFR-expressing target cells. The DER cell, an EGFR-expressing derivative of the interleukin-3-dependent hematopoietic 32D cell line, grows well in the presence of EGF or sHB-EGF without IL-3. When DER cells were co-cultured on a monolayer of Vero-H cells overexpressing pro-HB-EGF, growth inhibition and subsequent apoptosis were induced in the DER cells even in the presence of excess amounts of EGF or sHB-EGF. Such growth inhibition of DER cells was abrogated when specific antagonists for pro-HB-EGF were added in the culture medium or when direct contact of DER cells with Vero-H cells was prevented, indicating that pro-HB-EGF is involved in this inhibitory effect. Pro-HB-EGF-induced apoptosis of DER cells was also observed even in the presence of IL-3. This rules out the possibility of simple competition between soluble EGFR ligands and pro-HB-EGF. Moreover, 32D cells expressing EGFR mutant composed of the extracellular and the transmembrane domain of EGFR and the cytoplasmic domain of erythropoietin receptor did not undergo apoptosis by co-culture with Vero-H cells, indicating that the inhibitory signal induced by pro-HB-EGF-expressing Vero-H cells is mediated to DER cells via EGFR and that the cytoplasmic domain of EGFR is essential for pro-HB-EGF-induced apoptosis. From these results, we concluded that pro-HB-EGF has unique biological activity through cell-cell contact that is distinct from the activity of sHB-EGF.
Nonlinear model predictive control algorithm based on filter-trust-region method

In this paper, a filter-trust-region method is used in nonlinear model predictive control (NMPC) problem. By means of simultaneous approach based on nonlinear programming, an SQP sub-problem, which treats the iterate step Δu as an optimal variable, is built. After that, a trust region quadratic programming approach is used to solve the sub-problem, and the filter method is used to decide whether the trial point is better or not as an approximate solution to the optimization problem. And the Hessian matrix update method can also keep the sparse structure which is used to reduce the computational complexity. At last, the simulation result proves that the nonlinear predictive control algorithm based on filter-trust-region SQP method can get feasible solution within limited iterations at each time instant.
Determination of Interaction Sites on the Small G Protein RhoA for Phospholipase D*

Phospholipase D (PLD) has been identified as a target of small G proteins of the Rho family. The present study was directed at defining the interaction sites of RhoA with rat brain PLD in vitro using chimeric proteins between RhoA and Ha-Ras or Cdc42Hs and point mutations. The switch I region of RhoA, which is the common effector domain of Ras-like G proteins, was a crucial interaction site for PLD. Mutations in conserved amino acids (Tyr34, Thr37, Phe39) totally abolished PLD activation, while mutations in Val38 or Tyr42 caused partial loss. Two additional sites were responsible for the differential PLD activation ability between RhoA and Cdc42Hs. Changing Asp76 in the switch II region of RhoA to the corresponding amino acid in Cdc42Hs led to partial loss of PLD activation. A chimeric protein with the N-terminal third of Cdc42Hs changed to RhoA showed enhanced PLD activation. Analysis of other Rho/Ha-Ras chimeric proteins and mutations indicated that Gln52 adjacent to the switch II region is responsible for this gain of function. In conclusion, the present study shows that conserved amino acids in the switch I region of RhoA are major PLD interaction sites and that residues in the switch II and internal regions are responsible for the differential activation of PLD by RhoA and Cdc42Hs.
Realization of improved efficiency on nanostructured multicrystalline silicon solar cells for mass production

We report the realization of both excellent optical and electrical properties of nanostructured multicrystalline silicon solar cells by a simple and industrially compatible technique of surface morphology modification. The nanostructures are prepared by Ag-catalyzed chemical etching and subsequent NaOH treatment with controllable geometrical parameters and surface area enhancement ratio. We have examined in detail the influence of different surface area enhancement ratios on reflectance, carrier recombination characteristics and cell performance. By conducting a quantitative analysis of these factors, we have successfully demonstrated a higher-than-traditional output performance of nanostructured multicrystalline silicon solar cells with a low average reflectance of 4.93%, a low effective surface recombination velocity of 6.59 m s−1, and a certified conversion efficiency of 17.75% on large size (156 × 156 mm2) silicon cells, which is ∼0.3% higher than the acid textured counterparts. The present work opens a potential prospect for the mass production of nanostructured solar cells with improved efficiencies.
A successful technique for removing names in pathology reports using an augmented search and replace method

The ability to access large amounts of de-identified clinical data would facilitate epidemiologic and retrospective research. Previously described de-identification methods require knowledge of natural language processing or have not been made available to the public. We take advantage of the fact that the vast majority of proper names in pathology reports occur in pairs. In rare cases where one proper name is by itself, it is preceded or followed by an affix that identifies it as a proper name (Mrs., Dr., PhD). We created a tool based on this observation using substitution methods that was easy to implement and was largely based on publicly available data sources. We compiled a Clinical and Common Usage Word (CCUW) list as well as a fairly comprehensive proper name list. Despite the large overlap between these two lists, we were able to refine our methods to achieve accuracy similar to previous attempts at de-identification. Our method found 98.7% of 231 proper names in the narrative sections of pathology reports. Three single proper names were missed out of 1001 pathology reports (0.3%, no first name/last name pairs). It is unlikely that identification could be implied from this information. We will continue to refine our methods, specifically working to improve the quality of our CCUW and proper name lists to obtain higher levels of accuracy.
Sorafenib combined with radiofrequency ablation as treatment for patients with hepatocellular carcinoma: a systematic review and meta-analysis.

PURPOSE To evaluate the safety and efficacy of a combination of sorafenib and radiofrequency ablation (RFA) in patients with hepatocellular carcinoma (HCC). METHODS A systematic literature search was conducted using PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure (CNKI), China Biology Medicine disc (CBMdisc), WanFang Database, for all years up to January 2017. Pooled analyses of overall survival (OS), tumor- free survival, recurrence rates and adverse events were performed. RESULTS IA total of 7 case control studies consisting of 1765 HCC patients were selected and included in this metaanalysis. Patients treated with sorafenib-RFA and sorafenib alone, RFA alone and surgery had no significant differences in 1-year OS (p=0.310), 2-year OS (p=0.262), 3-year OS (p=0.179), 4-year OS (p=0.238) and 5-year OS (p=0.933); 1-year recurrence rate (p=0.653), 2-year recurrence rate (p=0.416), 3-year recurrence rate (p=0.304), and 5-year recurrence rate (p=0.807); 1-year tumor-free survival rate (p=0.943), 3-year tumor-free survival rate (p=0.825), 5-year tumor-free survival rate (p=0.893) and overall adverse events (p=0.097). CONCLUSION RFA-sorafenib combination may not be a better approach for patients with HCC. More well-designed randomized clinical trials (RCTs) should be performed before we finally arrive at a rational comprehension about the therapeutic value of the discussed options.
Double‐Blind, Randomized Comparison of the Analgesic and Pharmacokinetic Profiles of Controlled‐ and Immediate‐Release Oral Oxycodone in Cancer Pain Patients

Thirty patients with cancer pain completed a double‐blind crossover study comparing controlled‐release (CR) and immediate‐release (IR) oxycodone. In open‐label titration (2 to 21 days), these patients were stabilized on IR oxycodone qid. They were then randomized to double‐blind treatment with CR oxycodone q12h or IR oxycodone qid for 3 to 7 days followed by crossover at the same daily dose. Mean (± SD) pain intensity (0 = none to 10= severe) decreased from a baseline of 6.0 ± 2.2 to 2.7 ± 1.1 after titration with IR oxycodone dosed qid. Pain intensity remained stable throughout double‐blind treatment: 2.7 ± 1.9 with CR oxycodone and 2.8 ± 1.9 with IR oxycodone. Acceptability of therapy and pain scores correlated with plasma oxycodone concentrations for each interval and were similar for both medications (IR and CR oxycodone). Adverse events were similar for both formulations. Following repeat dosing under double‐blind conditions, oral CR oxycodone administered q12h provided analgesia comparable to IR oxycodone given qid.
Algorithm for Solving Massively Underdefined Systems of Multivariate Quadratic Equations over Finite Fields

Solving systems of m multivariate quadratic equations in n variables (MQ-problem) over finite fields is NP-hard. The security of many cryptographic systems is based on this problem. Up to now, the best algorithm for solving the underdefined MQ-problem is Hiroyuki Miura et al.'s algorithm, which is a polynomial-time algorithm when \[n \ge m(m + 3)/2\] and the characteristic of the field is even. In order to get a wider applicable range, we reduce the underdefined MQ-problem to the problem of finding square roots over finite field, and then combine with the guess and determine method. In this way, the applicable range is extended to \[n \ge m(m + 1)/2\], which is the widest range until now. Theory analysis indicates that the complexity of our algorithm is \[O(q{n^\omega }m{(\log {\kern 1pt} {\kern 1pt} q)^2}){\kern 1pt} \] when characteristic of the field is even and \[O(q{2^m}{n^\omega }m{(\log {\kern 1pt} {\kern 1pt} q)^2})\] when characteristic of the field is odd, where \[2 \le \omega \le 3\] is the complexity of Gaussian elimination.