Miracle-dz/UniFAR-FTUs huggingface dataset:
Cdc 25 B cooperates with Cdc 25 A to induce mitosis but has a unique role in activating cyclin B 1 – Cdk 1 at the centrosome

dc25 phosphatases are essential for the activation of mitotic cyclin–Cdks, but the precise roles of the three mammalian isoforms (A, B, and C) are unclear. Using RNA interference to reduce the expression of each Cdc25 isoform in HeLa and HEK293 cells, we observed that Cdc25A and -B are both needed for mitotic entry, whereas Cdc25C alone cannot induce mitosis. We found that the G2 delay caused by small interfering RNA to Cdc25A or -B was accompanied by reduced activities C of both cyclin B1–Cdk1 and cyclin A–Cdk2 complexes and a delayed accumulation of cyclin B1 protein. Further, three-dimensional time-lapse microscopy and quantification of Cdk1 phosphorylation versus cyclin B1 levels in individual cells revealed that Cdc25A and -B exert specific functions in the initiation of mitosis: Cdc25A may play a role in chromatin condensation, whereas Cdc25B specifically activates cyclin B1–Cdk1 on centrosomes.
Arsenic trioxide inhibits invasion/migration in SGC-7901 cells by activating the reactive oxygen species-dependent cyclooxygenase-2/matrix metalloproteinase-2 pathway

Arsenic trioxide (As2O3) has been shown to inhibit invasion/migration in cancer cells. However, the underlying mechanism is poorly understood. To identify the role of As2O3 in regulating invasion/migration activity in human gastric cancer SGC-7901 cells, the effects of As2O3 on cell invasion/migration activity, the expression of cyclooxygenase-2 (Cox-2), prostaglandin E2 (PGE2), thromboxane B2 (TXB2), leukotriene B4 (LTB4), and matrix metalloproteinase-2 (MMP-2) and intracellular reactive oxygen species (ROS) were examined. Furthermore, N-acetyl-l-cysteine (NAC, a radical scavenger) and celecoxib (a Cox-2 inhibitor) were used to explore the molecular mechanism. The results demonstrated that As2O3 (1 and 2 μmol/L) inhibited invasion/migration activity in SGC-7901 cells at 24 h and suppressed the expression of Cox-2, PGE2 and MMP-2 (P < 0.05), whereas the same treatment had no significant effect on TXB2 and LTB4 expression. In contrast, intracellular ROS were increased (P < 0.05). Moreover, NAC eliminated the excessive ROS and restored the expression of Cox-2 and MMP-2 and invasion/migration activity in As2O3-treated cells (P < 0.05). These results suggest that ROS may be a critical factor in regulating the invasion/migration process. Moreover, celecoxib significantly decreased Cox-2, MMP-2 and PGE2 expression and inhibited invasion/migration activity in As2O3-treated cells (P < 0.05), indicating that As2O3 inhibits invasion/migration by regulating the expression of Cox-2/PGE2/MMP-2. In conclusion, these results suggest that increased ROS play a critical role in inhibiting invasion/migration by suppressing the Cox-2/MMP-2 pathway in As2O3-treated SGC-7901 cells and regulating intracellular ROS levels may be a promising strategy in gastric cancer therapy.
Postoperative Changes in Fecal Bacterial Communities and Fermentation Products in Obese Patients Undergoing Bilio-Intestinal Bypass

We assessed the gut microbial ecology of 11 severely obese patients before and after bilio-intestinal bypass (BIB). Fecal samples were evaluated for microbial communities using 16S rDNA Illumina sequencing, real-time PCR targeting functional genes, and gas chromatography of short chain fatty acids (SCFAs). At 6 months after surgery, subjects exhibited significant improvements in metabolic markers (body weight, glucose, and lipid metabolism) compared with baseline. The fecal microbiota of post-surgery individuals was characterized by an overall decrease of bacterial diversity, with a significant reduction in Lachnospiraceae, Clostridiaceae, Ruminococcaceae, Eubacteriaceae, and Coriobacteriaceae. On the contrary, there were significant increases of genera Lactobacillus, Megasphaera, and Acidaminococcus and the family Enterobacteriaceae. The pH was decreased in fecal samples from patients after BIB and SCFA profiles were altered, with lower percentages of acetate and propionate and higher levels of valerate and hexanoate. Some changes in the bacterial populations were associated with variations in the patients' metabolic health parameters, namely Gemmiger and glucose, Lactobacillus and glucose, and Faecalibacterium and triglycerides. The results from this study of BIB patients furthers our understanding of the composition of gut microbiota and the functional changes that may be involved in improving obesity-related conditions following weight-loss surgery.
Ventilation in chronic heart failure: effects of physical training

Objective—To assess the effects of exercise training on ventilatory function in chronic heart failure. Design—Observer blinded random allocation crossover training and detraining trial. Setting—Assessment in hospital based clinical laboratory; training home based. Patients—22 patients with chronic heart failure (New York Heart Association (NYHA) class II or III) recruited from a tertiary referral centre. All finished the study. Intervention—Bicycle ergometer exercise for 20 minutes a day, five days a week for eight weeks at 70%–80% of maximum heart rate. Main outcome measures—Exercise capacity on graded incremental exercise test, minute ventilation, oxygen consumption and carbon dioxide output. Results—Peak work load increased from 96 W to 112 W and peak oxygen consumption from 14·1 ml`/kg/min to 15·4 ml/kg/min (p < 0·01). At submaximal workloads carbon dioxide excretion (Vco2) and minute ventilation (Vi) decreased significantly (p < 0·05) though oxygen consumption was unchanged. The relation between Vi and carbon dioxide excretion changed: the slope of the Vi to Vco2 plot decreased from 38·6 to 35·3, indicating an improvement in overall ventilary efficiency. The instantaneous carbon dioxide ventilatory equivalent (Vi/Vco2) decreased at submaximal workloads, and reached a lower mimimum value after training, indicating that optimum ventilatory performance improved. The exercise capacity of patients was related to the optimum ventilatory performance. It is suggested that this may in part be mediated through changes in skeletal muscles. Conclusion—Exercise training reduces the ventilatory abnormalities in chronic heart failure; thus some of these changes may be due to physical deconditioning.
Mixed-Mode Chaotic Circuit and its Application to Chaotic Communication for Transmission of Analog signals

We present a mixed-mode chaotic circuit which has both autonomous and nonautonomous chaotic circuit dynamics and we show how this mixed-mode chaotic circuit can be utilized in a chaotic communication system for transmitting analog signals. The investigation of static and dynamic analyses of the proposed circuit has been carried out and its chaotic behavior was verified by PSpice simulation experiments. For the transmission of analog signals via mixed-mode chaotic circuit, a well-known chaotic communication system introduced by Itoh et al. was chosen.
User-to-User Recommendation using the Concept of Movement Patterns: A Study using a Dating Social Network

© 2017 by SCITEPRESS - Science and Technology Publications. Dating Social Networks (DSN) have become a popular platform for people to look for potential romantic partners. However, the main challenge is the size of the dating network in terms of the number of registered users, which makes it impossible for users to conduct extensive searches. DSN systems thus make recommendations, typically based on user profiles, preferences and behaviours. The provision of effective User-to-User recommendation systems have thus become an essential part of successful dating networks. To date the most commonly used recommendation technique is founded on the concept of collaborative filtering. In this paper an alternative approach, founded on the concept of Movement Patterns, is presented. A movement pattern is a three-part pattern that captures the "traffic" (messaging) between vertices (users) in a DSN. The idea is that these capture the behaviour of users within a DSN while at the same time capturing the associated profile and preference data. The idea has been built into a User-to-User recommender system, the RecoMP system. The system has been evaluated, by comparing its operation with a collaborative filtering systems (the RecoCF system), using a data set from the Chinese Jiayuan.com DSN comprising 548,395 vertices. The reported evaluation demonstrates that very successful results can be produced, a best average F-score value of 0.961.
Approximation of homogeneous measures in the 2-Wasserstein metric

It is shown that, on certain weighted spaces of vector fields on R3, any homogeneous measure of finite energy density and dissipation can be approximated in the second Wasserstein distance by homogeneous measures supported by finite trigonometric polynomials of increasing period and degree. In particular, the periodic correlation functions of the approximation converge uniformly on compact sets of R3 to the correlation function of the given measure.
The Next Generation of Dietitians: Implementing Dietetics Education and Practice in Integrative Medicine

Integrative medicine is a quickly expanding field of health care that emphasizes nutrition as a key component. Dietitians and nutritionists have an opportunity to meet workforce demands by practicing dietetics and integrative medicine (DIM). The purpose of this article is to describe a DIM education program and practicum. We report the results of an interprofessional nutrition education and practicum program between the University of Kansas Medical Center (KUMC) Department of Dietetics and Nutrition and KU Integrative Medicine. This partnered program provides training that builds on the strong foundation of the Nutrition Care Process and adds graduate-level educational and practicum experiences in foundational integrative medicine knowledge, including nutritional approaches from a systems biology perspective, nutrigenomics, and biochemistry as the core knowledge to understand the root cause of a chronic disorder and to choose appropriate nutritional tools for interventions. This interprofessional KUMC program provides a dietetic internship, master's degree, and graduate certificate in DIM and fulfills a need for dietitians and nutritionists who seek careers practicing in an integrative medicine setting. The program fulfills expanding workforce needs to provide quality health care for patients with chronic illnesses.
Unipad: single stroke text entry with language-based acceleration

A stylus-based text entry technique called Unipad is presented. Unipad combines single-stroke text input with language-based acceleration techniques, including word completion, suffix completion, and frequent word prompting. In a study with ten participants, entry rates averaged 11.6 wpm with 0.90% errors after two hours of practice. In follow-on sessions to establish the expert potential, four users entered "the quick brown fox" phrase repeatedly for four blocks of 15 minutes each. Average rates on the last block ranged from 17.1 to 35.1 wpm, with peak rates reaching 48 wpm.
QUADRATIC HEDGING FOR CONTINGENT CLAIMS WITH DELTA CONSTRAINT

ABSTRACT In this paper, under constraint of delta-strategy and by importing another related risky asset to compose a hedging portfolio comprising the underlying asset and riskless asset(the Bond). Firstly, we excellently devise a dynamic hedging program for contingent claims; and then, according to Principle of Dynamic Programming and by taking advantage of backward recursion technique, at each rebalance moment before option’s maturity date, the optimal hedging strategies are acquired to (1) eliminate the diffusion risk by imposing delta constraint; and (2) depress the jump risk using the hedging portfolio, which minimize the mean squared error between the terminal valuation of hedging portfolio and the payment obligation that the option issuer may be charged with; lastly, at the end of this paper, empirical analysis and numerical results indicate that our proposed hedging strategy is not only efficacious and feasible but also convenient and simple to manipulate, at the same time, it is referential to hedging practice.
Legacies of precipitation fluctuations on primary production: theory and data synthesis

Variability of above-ground net primary production (ANPP) of arid to sub-humid ecosystems displays a closer association with precipitation when considered across space (based on multiyear averages for different locations) than through time (based on year-to-year change at single locations). Here, we propose a theory of controls of ANPP based on four hypotheses about legacies of wet and dry years that explains space versus time differences in ANPP–precipitation relationships. We tested the hypotheses using 16 long-term series of ANPP. We found that legacies revealed by the association of current- versus previous-year conditions through the temporal series occur across all ecosystem types from deserts to mesic grasslands. Therefore, previous-year precipitation and ANPP control a significant fraction of current-year production. We developed unified models for the controls of ANPP through space and time. The relative importance of current-versus previous-year precipitation changes along a gradient of mean annual precipitation with the importance of current-year PPT decreasing, whereas the importance of previous-year PPT remains constant as mean annual precipitation increases. Finally, our results suggest that ANPP will respond to climate-change-driven alterations in water availability and, more importantly, that the magnitude of the response will increase with time.
Rituximab dissociates the tight link between disease activity and joint damage in rheumatoid arthritis patients

Background/objective Progression of joint damage is linked to disease activity. This link is dissociated upon treatment with tumour necrosis factor (TNF)- or IL-6-inhibitors plus methotrexate (MTX). It is hitherto unknown if this may also be true for therapies targeting B-cells. We thus evaluated if rituximab (RTX) therapy inhibits joint damage irrespective of its effects on disease activity. Methods We used a random 90% sample of data from two arms of the IMAGE trial comprising patients with active early rheumatoid arthritis (RA) receiving MTX (n=188) or MTX+RTX 1000 mg (n=204). Patients were divided into low, moderate and high disease activity at one year of treatment by simplified disease activity index (low disease activity (LDA), moderate disease activity (MDA), high disease activity (HDA)), or by swollen joint count (SJC) or C reactive protein (CRP) tertiles. Progression of damage by the Genant modified total Sharp score (TGSS) was compared between therapies (Kruskal-Wallis, Wilcoxon tests) for each of these subgroups. Results In patients treated with MTX, 1-year progression of TGSS In LDA, MDA and HDA was 0.40±0.88, 1.04±1.73, and 1.31±3.02, respectively. In contrast, on RTX+MTX, TGSS progression was 0.38±1.07, 0.39±1.28, and −0.05±0.44, respectively (for MDA and HDA the progression of TGSS was significantly lower in the combined group than in the MTX group: p=0.003 and p=0.05, respectively). Additional analyses (tertiles of SJC, CRP, and matching for disease activity) confirmed the primary analysis. Conclusions In early RA, progression of joint damage increases with increasing disease activity on MTX. RTX plus MTX retards damage independently of its effects on disease activity, since even in HDA destruction is halted, contrasting MTX monotherapy. This indicates that beyond cytokine blockade (TNF- and IL-6 inhibitors), also cell-directed therapy (anti-CD20 antibody) conveys profound anti-destructive effects and dissociates the link between disease activity and joint damage.
The Role of Asymmetries and Regime Shifts in the Term Structure of Interest Rates

We examine the relationship between interest rates of different maturities for the US, Germany and Japan over the period 1982-2000, using a general, multivariate vector equilibrium correction modelling framework capable of simultaneously allowing for asymmetric adjustment and regime shifts. This approach has a very general underlying theoretical rationale that allows for time-varying term premia and other short-run deviations from the expectations model of the term structure. The resulting non-linear models provide good in-sample fits, display regime switches closely related to key state variables driving monetary policy decisions and have satisfactory out-of-sample forecasting properties.
RNA Polymerase IV Functions in Paramutation in Zea mays

Plants have distinct RNA polymerase complexes (Pol IV and Pol V) with largely unknown roles in maintaining small RNA–associated gene silencing. Curiously, the eudicot Arabidopsis thaliana is not affected when either function is lost. By use of mutation selection and positional cloning, we showed that the largest subunit of the presumed maize Pol IV is involved in paramutation, an inherited epigenetic change facilitated by an interaction between two alleles, as well as normal maize development. Bioinformatics analyses and nuclear run-on transcription assays indicate that Pol IV does not engage in the efficient RNA synthesis typical of the three major eukaryotic DNA-dependent RNA polymerases. These results indicate that Pol IV employs abnormal RNA polymerase activities to achieve genome-wide silencing and that its absence affects both maize development and heritable epigenetic changes.
Noninvasive measurement of cerebral oxygen saturation and cerebral phronetal function

Using the Near-Infrared Spectroscopy (NIRS), the noninvasive measurement of cerebral oxygen concentration can be achieved in vivo based on the Lambert-Beer Law. In this paper, we discuss the possibility of studying higher brain functions through combining cerebral oxygen saturation and cerebral function measurement. Event-related experiments are introduced to measure the cerebral phronetal function. Time domain curves show sight differences among these experiment results. However, with the aid of DFT, experiment data of all five human volunteers show the frequency near 20 Hz or 40 Hz is evoked depending on the difficulty of the mental tasks. The results demonstrate the feasibility of cerebral functions study by means of cerebral oxygen saturation measurement analyzed in the frequency domain.
Real-time emotion classification of tweets

Despite adding emotions to applications has proven to enhance the user experience, emotion recognition applications are still not widely available nor used. Within this paper, emotion recognition is done on Twitter tweets using six emotion classification algorithms that are compared on precision and timing. The paper shows that precision can be enhanced by 5.02% compared to the current state-of-the-art by improving the features. Furthermore, the presented algorithms work in real-time.
Hypervised transient SPICE simulations of large netlists & workloads on multi-processor systems

The need for detailed simulation of integrated circuits has received significant attention since the early stages of design automation. Given the increasing device integration, these simulations have extreme memory footprints, especially within unified memory hierarchies. This paper overcomes the infeasible memory demands of modern circuit simulators. Structural partitioning of the netlist and temporal partitioning of the input signals allow distributed execution with minimal memory requirements. The proposed framework is validated with simulations of a circuit with more than 106 MOSFET devices. In comparison to a commercial tool, we observe minimal error and even ×2.35 speedup for moderate netlist sizes. The proposed framework is proven highly reusable across a variety of execution platforms.
Assessment of existing information on Atlantic coastal fish habitats : development of a web-based spatial bibliography, query tools, and data summaries

The primary objective of this project, “the Assessment of Existing Information on Atlantic Coastal Fish Habitat”, is to inform conservation planning for the Atlantic Coastal Fish Habitat Partnership (ACFHP). ACFHP is recognized as a Partnership by the National Fish Habitat Action Plan (NFHAP), whose overall mission is to protect, restore, and enhance the nation’s fish and aquatic communities through partnerships that foster fish habitat conservation. This project is a cooperative effort of NOAA/NOS Center for Coastal Monitoring and Assessment (CCMA) Biogeography Branch and ACFHP. The Assessment includes three components; 1. a representative bibliographic and assessment database, 2. a Geographical Information System (GIS) spatial framework, and 3. a summary document with description of methods, analyses of habitat assessment information, and recommendations for further work. The spatial bibliography was created by linking the bibliographic table developed in Microsoft Excel and exported to SQL Server, with the spatial framework developed in ArcGIS and exported to GoogleMaps. The bibliography is a comprehensive, searchable database of over 500 selected documents and data sources on Atlantic coastal fish species and habitats. Key information captured for each entry includes basic bibliographic data, spatial footprint (e.g. waterbody or watershed), species and habitats covered, and electronic availability. Information on habitat condition indicators, threats, and conservation recommendations are extracted from each entry and recorded in a separate linked table. The spatial framework is a functional digital map based on polygon layers of watersheds, estuarine and marine waterbodies derived from NOAA’s Coastal Assessment Framework, MMS/NOAA’s Multipurpose Marine Cadastre, and other sources, providing spatial reference for all of the documents cited in the bibliography. Together, the bibliography and assessment tables and their spatial framework provide a powerful tool to query and assess available information through a publicly available web interface. They were designed to support the development of priorities for ACFHP’s conservation efforts within a geographic area extending from Maine to Florida, and from coastal watersheds seaward to the edge of the continental shelf. The Atlantic Coastal Fish Habitat Partnership has made initial use of the Assessment of Existing Information. Though it has not yet applied the AEI in a systematic or structured manner, it expects to find further uses as the draft conservation strategic plan is refined, and as regional action plans are developed. It also provides a means to move beyond an “assessment of existing information” towards an “assessment of fish habitat”, and is being applied towards the National Fish Habitat Action Plan (NFHAP) 2010 Assessment. Beyond the scope of the current project, there may be application to broader initiatives such as Integrated Ecosystem Assessments (IEAs), Ecosystem Based Management (EBM), and Marine Spatial Planning (MSP).
A Generalized Two-Way Relay Channel with Private Information for the Relay

In the conventional two-way relay channel, two sources exchange information with help from a relay. We introduce a generalized two-way relay channel where each source additionally sends private information to the relay. For this channel, we consider a protocol that consists of a multiple-access (MA) phase and a broadcast (BC) phase and obtain achievable rate regions for both phases. The MA phase is related to computation over the multiple-access channel (MAC). We show that our scheme achieves rates that always lie within half bit of the capacity region for computation over MAC, and is capacity achieving in the BC phase. This near optimality in the MA phase can be achieved by time sharing a capacity-achieving code for the MAC and a superposition code that uses a lattice code as its component code.