Miracle-dz/UniFAR-FTUs huggingface dataset:
Data mining in action : case studies of enrollment management

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Measurements of Sit-to-Stand Timing and Symmetry From Bed Pressure Sensors

Sit-to-stand (SiSt) analysis has been widely used in clinical practice to assess the risk of falls in the older adult population. This paper proposes automated algorithms for the unobtrusive measurement of SiSt timing and symmetry using bed pressure sensors. An integrated signal comprising all of the sensor outputs was analyzed to measure both the bed-departure timing and the timing of three clinical phases within the transfer. Data collected in clinical trials, along with independent clinical video analysis, verified the success of the bed-departure timing algorithm with a mean error of 0.11 s. The phase measurement algorithm showed significant differences (p <; 0.001) between younger and older adults in Phases II and III of the transfers, comparing well with studies found in recent clinical literature. The sensor outputs were then used to form sequences of pressure images, and an automated region of interest (ROI) detection algorithm was designed to extract regional signals from the hips and the hands. The final algorithm was designed to measure the symmetry of the body throughout the SiSt transfer from the extracted regional signals. A system accuracy of 93.0% was obtained for the automated symmetry classification of transfers. The techniques proposed in this paper can increase the precision and efficiency in clinical SiSt assessments. Their unobtrusive nature makes them particularly suitable for integration into a continuous monitoring system such as those required within the smart home environment.
Part 6: Alternative Techniques and Ancillary Devices for Cardiopulmonary Resuscitation: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care.

Conventional cardiopulmonary resuscitation (CPR) consisting of manual chest compressions with rescue breaths is inherently inefficient with respect to generating cardiac output. A variety of alternatives and adjuncts to conventional CPR have been developed, with the aim of enhancing perfusion during resuscitation from cardiac arrest. Since the publication of the 2010 American Heart Association (AHA) Guidelines for CPR and Emergency Cardiovascular Care (ECC),1 a number of clinical trials have provided additional data on the effectiveness of these alternatives and adjuncts. Compared with conventional CPR, many of these techniques and devices require specialized equipment and training. Some have only been tested in highly selected subgroups of cardiac arrest patients; this context must be considered when rescuers or healthcare systems are considering implementation. ### Methodology The recommendations in this 2015 AHA Guidelines Update for CPR and ECC are based on an extensive evidence review process that was begun by the International Liaison Committee on Resuscitation (ILCOR) after the publication of the ILCOR 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations 2,3 and was completed in February 2015.4,5 In this in-depth evidence review process, the ILCOR Advanced Life Support (ALS) Task Force examined topics and then generated a prioritized list of questions for systematic review. Questions were first formulated in PICO (population, intervention, comparator, outcome) format,6 search strategies and criteria for inclusion and exclusion of articles were defined, and then a search for relevant articles was performed. The evidence was evaluated by the ILCOR ALS Task Force by using the standardized methodological approach proposed by the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) Working Group.7 The quality of the evidence was categorized based on the study methodologies and the 5 core GRADE domains of risk of bias, inconsistency, indirectness, imprecision, and …
Effect of motor imagery training and electromyogram-triggered neuromuscular electrical stimulation on lower extremity function in stroke patients: a pilot trial

[Purpose] To investigate the effect of motor imagery training and electromyogram-triggered neuromuscular electrical stimulation (MIT-EMG NMES) on the lower extremity function of stroke patients. [Subjects and Methods] This study recruited eight patients with hemiplegia due to stroke. All patients received MIT-EMG NMES for 20 min daily, 5 days per week for 4 weeks. Lower extremity function were assessed using the timed up-and-go (TUG) and 10-meter walk (10MW) tests. [Results] The results of TUG test decreased significantly from 20.5 ± 4.5 to 14.0 ± 3.5 s, while those of 10 MW test showed a significant decrease from 21.3 ± 4.5 to 15.5 ± 3.2 m. [Conclusion] This study suggests that MIT-EMG NMES is a new rehabilitation therapy for lower extremity recovery in hemiplegic stroke patients.
Estimating the Population Burden of Lymphedema

Lymphedema is a complex, regional edematous state that ensues when lymph transport is insufficient to maintain tissue homeostasis. The disorder is remarkably prevalent, but the population implications of lymphatic dysfunction are not well‐studied. Prevalence estimates for lymphedema are relatively high, yet its prevalence is likely underestimated. The ability to estimate the burden of disease poses profound implications for current and future lymphedema patients, but the challenge to correctly surmise the incidence and prevalence of lymphedema is complex and the relevant medical literature is scanty. In the absence of the highly desired, prospectively designed and rigorously performed relevant epidemiologic studies, it is instructive to look at the existing studies of lymphedema disease burden. In the current review, the extant literature is examined in the context of the disease setting in which tissue edema is encountered. Incidence or prevalence estimates are provided or inferred, and, where feasible, the size of the subject population is also identified. It is extremely attractive to contemplate that future approaches will entail formal, prospectively designed studies to objectively quantitate incidence and prevalence statistics for individual categories, as well as for the global lymphedema population.
The Wessex Recent In-Patient Suicide Study, 2

Background Psychiatric patients have an elevated risk of suicide while in hospital. Aims To compare social, clinical and health-care delivery factors in in-patient and out-patient suicides and their controls. Method Retrospective case-control study of 59 in-patients and 106 controls, matched for age, gender, diagnosis and admission date. Odds ratios were calculated using conditional multiple logistic regression. Results There were seven independent increased-risk factors: history of deliberate self-harm, admission under the Mental Health Act, involvement of the police in admission, depressive symptoms, violence towards property, going absent without leave and a significant care professional being on leave. When compared with out-patient suicides, in-patients were more often female and male in-patients had a psychotic illness. Unlike the out-patient suicides, social factors were not found to be significant. Conclusions The characteristics of inpatient and out-patient suicides differ. Identified risk factors have relatively low sensitivity and specificity.
A Non-overlapping Domain Decomposition Method with Inexact Solvers

In this paper we are concerned with non-overlapping domain decomposition methods for the second-order elliptic problems in three-dimensional domains. We develop a new kind of substructuring method, in which one can use an inexact solver both in each subdomain and on each local interface. The main ideas are to decompose the interface space into the sum of small local subspaces and a series of coarse subspaces spanned by constant-like basis functions, and to design a cheap approximate harmonic extension of the constant-like function. It will be shown that the condition number of the preconditioned system grows only as the logarithm of the dimension of the local problem associated with an individual substructure, and is independent of possible jumps of the coefficient in the elliptic equation.
Incarceration, sex with an STI- or HIV-infected partner, and infection with an STI or HIV in Bushwick, Brooklyn, NY: a social network perspective.

OBJECTIVES We examined the link between incarceration and sexually transmitted infection (STI), including HIV, from a social network perspective. METHODS We used data collected during a social network study conducted in Brooklyn, NY (n = 343), to measure associations between incarceration and infection with herpes simplex virus-2, chlamydia, gonorrhea, and syphilis or HIV and sex with an infected partner, adjusting for characteristics of respondents and their sex partners. RESULTS Infection with an STI or HIV was associated with incarceration of less than 1 year (adjusted prevalence ratio [PR] = 1.33; 95% confidence interval [CI] = 1.01, 1.76) and 1 year or longer (adjusted PR = 1.37; 95% CI = 1.08, 1.74). Sex in the past 3 months with an infected partner was associated with sex in the past 3 months with 1 partner (adjusted PR = 1.42; 95% CI = 1.12, 1.79) and with 2 or more partners (adjusted PR = 1.85; 95% CI = 1.43, 2.38) who had ever been incarcerated. CONCLUSIONS The results highlight the need for STI and HIV treatment and prevention for current and former prisoners and provide preliminary evidence to suggest that incarceration may influence STI and HIV, possibly because incarceration increases the risk of sex with infected partners.
Monoubiquitination Is Sufficient To Signal Internalization of the Maltose Transporter in Saccharomyces cerevisiae

ABSTRACT Monoubiquitination of the 12-transmembrane segment (12-TMS)Saccharomyces cerevisiae maltose transporter promoted the maximal internalization rate of this protein. This modification is similar to that of the 7-TMS α-factor receptor but different from that of the 12-TMS uracil and general amino acid permeases. This result shows that binding of ubiquitin-Lys63 chains is not required for maximal internalization of all 12-TMS-containing proteins.
Effects of multisite biventricular pacing in patients with heart failure and intraventricular conduction delay.

BACKGROUND One third of patients with chronic heart failure have electrocardiographic evidence of a major intraventricular conduction delay, which may worsen left ventricular systolic dysfunction through asynchronous ventricular contraction. Uncontrolled studies suggest that multisite biventricular pacing improves hemodynamics and well-being by reducing ventricular asynchrony. We assessed the clinical efficacy and safety of this new therapy. METHODS Sixty-seven patients with severe heart failure (New York Heart Association class III) due to chronic left ventricular systolic dysfunction, with normal sinus rhythm and a duration of the QRS interval of more than 150 msec, received transvenous atriobiventricular pacemakers (with leads in one atrium and each ventricle). This single-blind, randomized, controlled crossover study compared the responses of the patients during two periods: a three-month period of inactive pacing (ventricular inhibited pacing at a basic rate of 40 bpm) and a three-month period of active (atriobiventricular) pacing. The primary end point was the distance walked in six minutes; the secondary end points were the quality of life as measured by questionnaire, peak oxygen consumption, hospitalizations related to heart failure, the patients' treatment preference (active vs. inactive pacing), and the mortality rate. RESULTS Nine patients were withdrawn from the study before randomization, and 10 failed to complete both study periods. Thus, 48 patients completed both phases of the study. The mean distance walked in six minutes was 22 percent greater with active pacing (399+/-100 m vs. 326+/-134 m, P<0.001), the quality-of-life score improved by 32 percent (P<0.001), peak oxygen uptake increased by 8 percent (P<0.03), hospitalizations were decreased by two thirds (P<0.05), and active pacing was preferred by 85 percent of the patients (P<0.001). CONCLUSIONS Although it is technically complex, atriobiventricular pacing significantly improves exercise tolerance and quality of life in patients with chronic heart failure and intraventricular conduction delay.
Coding for a write-once memory

A write-once memory (WOM) is a binary storage medium in which the individual bit positions can be changed from the 0 state to the 1 state only once. Examples of WOMs are paper tapes, punched cards, and, most importantly, optical disks. For the latter storage medium, the l's are marked by a laser that burns away a portion of the disk. In a recent paper, Rivest and Shamir showed that it is possible to update or rewrite a WOM to a surprising degree, and that the total amount of information which can be stored in an JV-position WOM in many write/read "generations" or "stages" can be much larger than N.1 In this paper we extend their results in several directions. Let C(T, N) be the total number of bits of information that can be stored in an N-position WOM using T write/read generations. We consider the four cases that result when the writer (encoder) and/or reader (decoder) know the state of the memory at the previous generation. For three of these cases, when either the encoder and/or decoder knows the previous state, we show that C(T, N) ∼ N log(T + 1), with T held fixed, as A→∞. For the remaining case, when neither the encoder nor the decoder knows the previous state, we show that C(T, N) < N Π2(6 In 2) ≈AT (2.37) and that this bound can be approached arbitrarily closely with T, N sufficiently large.
Temperature, humidity and pressure measurement on automotive connectors

Environmental testing under laboratory-controlled conditions has long been used to evaluate connector performance prior to practical application. There are a number of experimental procedures frequently used in the automotive industry such as the USCAR standard for automotive electrical connector systems to test connectors. However, recent research has shown that these tests appear to evaluate the mechanical stability of the connector housings and terminals, rather than their electrical performance. In order to establish more representative tests to evaluate the electrical performance of contacts, the actual environmental conditions at the contact interface, which are generally unknown, must be measured. This paper compares the temperature, humidity, and air pressure inside the connector housing to those measured outside. It was found that the conditions inside and outside the connector housing are different and a model relating the conditions is introduced
African American Women and Prenatal Care

Poor patient–provider interaction among racial/ethnic minorities is associated with disparities in health care. In this descriptive, cross-sectional study, we examine African American women’s perspectives and experiences of patient–provider interaction (communication and perceived discrimination) during their initial prenatal visit and their influences on perceptions of care received and prenatal health behaviors. Pregnant African American women (n = 204) and their providers (n = 21) completed a pre- and postvisit questionnaire at the initial prenatal visit. Women were also interviewed face to face at the subsequent return visit. Women perceived high quality patient–provider communication (PPC) and perceived low discrimination in their interaction with providers. Multiple regression analyses showed that PPC had a positive effect on trust in provider (p < .001) and on prenatal care satisfaction (p < .001) but not on adherence to selected prenatal health behaviors. Findings suggest that quality PPC improves the prenatal care experience for African American women.
Effect of increased mechanical knee joint loading during running on the serum concentration of cartilage oligomeric matrix protein (COMP)

The purpose of the study was to investigate the effect of an increase in mechanical knee joint loading during running on the serum COMP level. On two different test days, 20 healthy men ran with knee orthoses for 30 min on a treadmill (v = 2.2 m/s). On day 1, the orthoses were passive, whereas on day 2 they were pneumatically driven (active) and thus increased the external knee flexion moments (+30.9 Nm) during stance phase. Lower‐limb mechanics and serum COMP levels (baseline; 0, 0.5, 1, 2 h post running) were analyzed. COMP levels increased immediately after running with passive (+35%; pre: 7.5 U/l, 95%CI: 6.4, 8.7, post: 9.8 U/l, 95%CI: 8.8, 10.8, p < 0.001) and active orthoses (+45%; pre: 7.6 U/l; 95%CI: 6.4, 8.8, post: 10.3 U/l, 95%CI: 9.2, 11.5, p < 0.001), but they did not differ between interventions. While running with active orthoses, greater ankle dorsiflexion angles, knee flexion angles, and moments occurred (p < 0.05). Comparing both interventions, the Δ COMP pre–post, meaning the difference (Δ) between running with active and passive orthoses in pre to post COMP level change (=level after (post) running minus level before (pre) running), correlated negatively with Δ COMP baseline (difference between the baseline COMP level before running with active and passive orthoses, r = −0.616; p = 0.004), and with a positive tendence with the Δ maximum knee flexion (r = 0.388; p = 0.091). Therefore, changes in COMP concentration after physical activity seem to be highly influenced by the COMP baseline level. In addition, correlation analysis indicates that modifications in knee joint kinematics have a greater effect on cartilage metabolism than an increase in joint moments. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1937–1946, 2018.
Asymmetric Relationship between Extreme Investor Sentiment and Stock Index

In terms of the multifactor effects on investor sentiment and different effects of investor sentiment on stock index,this paper adjusts the indicator of short-and long-term investor sentiment-weekly and monthly HAODAN indexfor time trend and holiday effect.Then we sort the investor sentiment by the deviation level and direction from the mean into four sets:(non-)extreme optimistic and(non-)extreme pessimistic.Moreover,we structure a regressive model to investigate the impacts of investor sentiment,especially extreme investor sentiment on stock index.The results imply that:(1) the impact of extreme and non-extreme sentiment on stock index is different;(2) the impact of extreme optimistic sentiment and extreme pessimistic sentiment on stock index is asymmetric;(3) the impact of short-and long-term extreme pessimistic sentiment on stock index is negative.
Interindividual Variation in Posture Allocation: Possible Role in Human Obesity

Obesity occurs when energy intake exceeds energy expenditure. Humans expend energy through purposeful exercise and through changes in posture and movement that are associated with the routines of daily life [called nonexercise activity thermogenesis (NEAT)]. To examine NEAT's role in obesity, we recruited 10 lean and 10 mildly obese sedentary volunteers and measured their body postures and movements every half-second for 10 days. Obese individuals were seated, on average, 2 hours longer per day than lean individuals. Posture allocation did not change when the obese individuals lost weight or when lean individuals gained weight, suggesting that it is biologically determined. If obese individuals adopted the NEAT-enhanced behaviors of their lean counterparts, they might expend an additional 350 calories (kcal) per day.
Impact of Genetic Manipulation on the Fitness of Anopheles stephensi Mosquitoes

Genetic modification of mosquitoes offers exciting possibilities for controlling malaria, but success will depend on how transformation affects the fitness of modified insects. The expression of an exogenous gene, the mutations caused by its insertion, and inbreeding while transformed lines are established can all lead to reductions in fitness. Factors influencing fitness were investigated in cage experiments with four lines of transgenic Anopheles stephensi, a vector species of human malaria. The results indicate direct costs of the introduced transgene in at least three out of the four lines, as well as an apparent cost of the inbreeding involved in making transgenic homozygotes.
Characterization and localization of the even‐skipped protein of Drosophila.

On the basis of homeo box cross‐homology we have isolated the pair‐rule gene even‐skipped (eve) of Drosophila. The eve transcription unit appears to be less than 1.5 kb in length, and encodes a single mRNA of approximately 1.4 kb. The nucleotide sequence of genomic and cDNA clones indicates that the eve protein is composed of 376 amino acid residues, and that its homeo domain shares only approximately 50% amino acid identity with the homeo domains of previously characterized genes. Using antibodies raised against a beta‐galactosidase fusion protein we show that the eve protein is distributed in a series of seven transverse stripes at the cellular blastoderm stage, and is localized primarily within the nuclear regions of those embryonic cells that express the gene. After gastrulation, seven weakly stained stripes of eve expression appear, resulting in a transient pattern that consists of a total of 14 evenly spaced stripes. Both the original and new stripes gradually disappear during germ band elongation. A second expression pattern emerges during neurogenesis, whereby eve protein is detected in discrete subsets of neurons in each of the ventral ganglia.
A resource for functional profiling of noncoding RNA in the yeast Saccharomyces cerevisiae

Eukaryotic genomes are extensively transcribed, generating many different RNAs with no known function. We have constructed 1502 molecular barcoded ncRNA gene deletion strains encompassing 443 ncRNAs in the yeast Saccharomyces cerevisiae as tools for ncRNA functional analysis. This resource includes deletions of small nuclear RNAs (snRNAs), transfer RNAs (tRNAs), small nucleolar RNAs (snoRNAs), and other annotated ncRNAs as well as the more recently identified stable unannotated transcripts (SUTs) and cryptic unstable transcripts (CUTs) whose functions are largely unknown. Specifically, deletions have been constructed for ncRNAs found in the intergenic regions, not overlapping genes or their promoters (i.e., at least 200 bp minimum distance from the closest gene start codon). The deletion strains carry molecular barcodes designed to be complementary with the protein gene deletion collection enabling parallel analysis experiments. These strains will be useful for the numerous genomic and molecular techniques that utilize deletion strains, including genome-wide phenotypic screens under different growth conditions, pooled chemogenomic screens with drugs or chemicals, synthetic genetic array analysis to uncover novel genetic interactions, and synthetic dosage lethality screens to analyze gene dosage. Overall, we created a valuable resource for the RNA community and for future ncRNA research.