Miracle-dz/UniFAR-FTUs huggingface dataset:
miR-146a Is Differentially Expressed by Myeloid Dendritic Cell Subsets and Desensitizes Cells to TLR2-Dependent Activation

Langerhans cells (LCs) in epithelia and interstitial dendritic cells (intDCs) in adjacent connective tissues represent two closely related myeloid-derived DC subsets that exert specialized functions in the immune system and are of clinical relevance for cell therapy. Both subsets arise from monocyte-committed intermediates in response to tissue-associated microenvironmental signals; however, molecular mechanisms underlying myeloid DC subset specification and function remain poorly defined. Using microarray profiling, we identified microRNA (miRNA) miR-146a to be constitutively expressed at higher levels in human LCs compared with intDCs. Moreover, miR-146a levels were low in monocytes and nondetectable in neutrophil granulocytes. Interestingly, constitutive high miR-146a expression in LCs is induced by the transcription factor PU.1 in response to TGF-β1, a key microenvironmental signal for epidermal LC differentiation. We identified miR-146a as a regulator of monocyte and DC activation but not myeloid/DC subset differentiation. Ectopic miR-146a in monocytes and intDCs interfered with TLR2 downstream signaling and cytokine production, without affecting phenotypic DC maturation. Inversely, silencing of miR-146a in LCs enhanced TLR2-dependent NF-κB signaling. We therefore conclude that high constitutive miR-146a levels are induced by microenvironmental signals in the epidermis and might render LCs less susceptible to inappropriate activation by commensal bacterial TLR2 triggers at body surfaces.
Voice Onset Time Variations of Korean Stop Consonants in Aphasic Speakers

Objective To compare the voice onset time (VOT) differences of Korean stops in the initial and intervocalic positions between the aphasic patients with peculiarities of aspiration and a control group. Method We examined 15 aphasic patients (nine males, six females) who had suffered a stroke (average age 49.7 years) and 15 healthy controls (average age 47.4 years). An aphasia examination was made by an aphasia battery of three standard tests and VOT was analyzed instrumentally. Stop consonants in the initial and intervocalic position were measured to categorize them according to aphasia types, place of articulation, and manner of articulation. Results VOT of the aphasic patients with peculiarities of aspiration had a greater difference than that of the controls, indicating that the temporal non-coordination between the laryngeal adjustment and oral articulators of aphasic patients happens due to the VOT of stops in the initial and intervocalic positions (p<0.05). Conclusion VOT of stop consonants in the initial position produced by aphasic patients tends to be proportional to their breathing. It can cause glottal width and make aphasic patients' VOT duration longer. Lastly, the method to measure the VOT of aphasic patients is more significant for the types of phonation than for the places of articulation, and makes it possible to induce abnormal VOT.
EANM/SNMMI Guideline for 18F-FDG Use in Inflammation and Infection*

1Department of Nuclear Medicine, Universite Catholique de Louvain, Brussels, Belgium; 2Department of Nuclear Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom; 3Nuclear Medicine, Istituto Clinico Humanitas, Milan, Italy; 4Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah; 5Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee; 6Department of Nuclear Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; 7Department of Nuclear Medicine, Rambam Health Care Campus, Haifa, Israel; 8Nuclear Medicine Department, Hospital Universitario de Bellvitge, Barcelona, Spain; and 9Nuclear Medicine Unit, Faculty of Medicine and Psychology, University “Sapienza,” Rome, Italy
An interdisciplinary view on dynamic models for plant genetics and morphogenesis: scope, examples and emerging research avenues

The iterative application of experimental and theoretical approaches to genetics and morphogenesis has proven extremely useful to many ends. On the one hand, alternating experimentation and modeling has allowed to integrate vast and complex sets of data into formal frameworks (Albert, 2007; Alvarez-Buylla et al., 2007; Pu and Brady, 2010). This alone has yielded a panoramic view of diverse study systems in plants, on which this editorial focuses, but also in animals, fungi, and prokaryotes (Alvarez-Buylla et al., 2008; Davidich and Bornholdt, 2008; Gonzalez-Rodriguez et al., 2012; Middleton et al., 2012), helping to identify openings and solving apparent inconsistencies in the sets of available data. On the other hand, mathematical models in genetics and morphogenesis have helped uncover some of the complex processes behind pattern and organ formation in plants, which has given rise to testable predictions that in turn input experimental work (Meinhardt et al., 1998; Espinosa-Soto et al., 2004; Prusinkiewicz et al., 2007; Azpeitia et al., 2010; Hamant et al., 2010; Mirabet et al., 2012). Yet, as a valuable and integrative approach, joint theoretical and experimental studies have opened new questions and research avenues in plant genetics, development and evolution, and thus face new challenges. Such challenges include assessing and comparing the scope and limitations of the diverse modeling frameworks and tools, as well as putting forward methods to study the emergence of spatiotemporal patterns from complex interactions among genes, proteins, hormones, physico-chemical mechanisms, environmental factors, among others.
Late Permian conchostracans (Crustacea, Branchiopoda) from continental deposits in the Moscow Syneclise, Russia

Abstract. The Moscow Syneclise on the East European Platform is an important area for the study of the continental biota of late Permian to Early Triassic age in continuous sections. This study attempts a taxonomic description of the late Permian conchostracan fauna of this area. The rich, new material was collected, bed by bed, during geological and paleontological excavations of lacustrine and fluvial deposits of the Obnora Formation and Vokhma Formation of the late Permian Zhukovian Regional Stage near the towns of Vyazniki and Gorokhovets. The conchostracan fauna of the Zhukovian Regional Stage consists predominantly of Pseudestheria and less frequently of Palaeolimnadiopsis. In the earliest Triassic Vokhmian Regional Stage, a more diverse fauna including Euestheria, Magniestheria, Cornia, Palaeolimnadiopsis, and Rossolimnadiopsis was already recorded. The preliminary taxonomic determination of the pseudestheriids from the Zhukovian Regional Stage is intended to serve as a prerequisite for future studies of late Permian conchostracan biostratigraphy on the regional to interregional scale.
A Generalized Data mining Framework for Placement Chance Prediction Problems

Data Mining is such a promising technology whose worth becomes evident when it can be applied to a domain where a common man is benefited. This paper is an attempt to help the prospective students to make wise career decisions using technologies like data mining using decision trees, Naive Bayes and artificial neural networks. A student enters his Entrance Rank, Gender (M/F), Sector (rural/urban) and Reservation category. Based on the entered information the Network or the decision tree will return which branch of study is Excellent, Good, Average or poor for him/her. Also in this paper we compare the performance of the models on the same data and propose a generalized data mining framework for problems of similar nature. General terms Data mining, classification, framework, performance comparison
Safety of Intravenous Application of Mistletoe (Viscum album L.) Preparations in Oncology: An Observational Study

Background. Traditional mistletoe therapy in cancer patients involves subcutaneous applications of Viscum album L. preparations, with doses slowly increasing based on patient responses. Intravenous infusion of high doses may improve therapeutic outcomes and is becoming more common. Little is known about the safety of this “off-label” application of mistletoe. Methods. An observational study was performed within the Network Oncology. Treatment with intravenous mistletoe applications is described. The frequency of adverse drug reactions (ADRs) to intravenous mistletoe applications was calculated and compared to ADR data from a study on subcutaneous applications. Results. Of 475 cancer patients who received intravenous infusions of Helixor, Abnoba viscum, or Iscador mistletoe preparations, 22 patients (4.6%) reported 32 ADRs of mild (59.4%) or moderate severity (40.6%). No serious ADRs occurred. ADRs were more frequently reported to i.v. mistletoe administered alone (4.3%), versus prior to chemotherapy (1.6%). ADR frequency differed with respect to preparation type, with Iscador preparations showing a higher relative frequency, compared to Abnoba viscum and Helixor. Overall, patients were almost two times less likely to experience an ADR to intravenous compared to subcutaneous application of mistletoe. Conclusion. Intravenous mistletoe therapy was found to be safe and prospective studies for efficacy are recommended.
The Relationship between the Edge Density of the Forest Fragments and the Tree Species Richness in the Detached Fragments of Kakamega Forest.

Purpose: The theoretical approach guiding this study was based on the Island Biogeography Theory. The purpose of this study was to assess the influence of the edge density of the forest fragments on tree species richness. Methodology: The study adopted a cross-sectional correlational research design. Proportionate random sampling was used. A sample of 30 plots each measuring 2m by 2m was established randomly in the fragments (0-200m from the edge towards the interior);Malava: Kisere: Ikuywa in that order for field sampling and measurements. Data was collected using tools such as measuring tapes,metre rule,GPS 64s Garmain and suunto inclinometer. A total of 39 species of trees were recorded from the three fragments with Funtumia africana being recorded as the most abundant species. Findings: The findings show 83%, 85%, and 92% variation of tree species richness in. Malava (r2 = 0.83), Kisere (r2 = 0.85) and Ikuywa (r2 = 0.92) in that order can be explained by the edge density of the fragments. The edge density also explained 87%, 94% and 94% variation of tree species relative abundance in Malava (r2 = 0.87), Kisere (r2 = 0.94) and Ikuywa (r2 = 0.94) in that order. Unique Contributor to Theory, Policy and Practice: It was concluded that tree species richness and tree species abundance in the detached portions of Kakamega forest were dominantly influenced by forest fragment total edge length and fragment edge density. For us to conserve more tree species we recommend maintenance of the total edge length of the fragments above 15km with edge density (3.413.79m\m2) in order to maintain high tree species richness and tree species relative abundance.
Sources of Health Insurance and Characteristics of the Uninsured: Analysis of the March 2002 Current Population Survey

This Issue Brief provides summary data on the insured and uninsured populations in the nation and in each state. It discusses the characteristics most closely related to an individual's health insurance status. Based on EBRI estimates from the March 2001 Current Population Survey (CPS), it represents 2000 data--the most recent available. Between 1999 and 2000, the percentage of Americans with health insurance increased: 84.1 percent of nonelderly Americans were covered by some form of health insurance in 2000, up from 83.8 percent in 1999. The percentage of nonelderly Americans without health insurance coverage declined from 16.2 percent in 1999 to 15.9 percent in 2000, continuing a trend that started between 1998 and 1999. The main reason for the decline in the number of uninsured Americans was the strong economy and low unemployment. Between 1999 and 2000, the percentage of nonelderly Americans covered by employment-based health insurance increased from 66.6 percent to 67.3 percent, continuing a longer-term trend that started between 1993 and 1994. In 2000, 34.3 million Americans received health insurance from public programs, and an additional 16.1 million purchased it directly from an insurer. More than 25 million Americans participated in Medicaid or the State Children's Health Insurance Program, and 6.1 million received their health insurance through the Tricare and CHAMPVA programs and other government programs designed to provide coverage for retired military members and their families. Even though the number and percentage of uninsured declined substantially between 1998 and 2000, more than 38 million Americans remain uninsured. While an increasing percentage of Americans were being covered by employment-based health plans, this trend may not continue because of the combined re-emergence of health care cost inflation and the weak economy. As long as the economy is strong and unemployment is low, employment-based health insurance coverage will expand and the uninsured will decline gradually. However, the combination of the current weak economy and the rising cost of providing health benefits will likely result in more Americans without health insurance coverage. Should the uninsured remain unchanged and continue to represent 15.9 percent of the nonelderly population, 40 million would be uninsured by 2005. If the uninsured represented 25 percent of the population, 63 million would be uninsured in 2005 and 65 million nonelderly Americans would be uninsured by 2010.
Acetonemia in Dairy Cows.

E XPERIENCES with Acetonemia in dairy cows during the past few months have revealed that in this locality the disease is quite prevalent. The frequency of its occurrence together with the loss in milk production and other expense indicate that it is of increasing importance to the dairymen. A good many farmers endeavor to treat what they diagnose as indigestion themselves and in some instances good results follow, but on occasions some of these so-called cases of indigestion do not respond to the dose of Epsom salts and the veterinarian when called finds that acetonemia is the cause of the persistent illness. When the acetonuria test is applied and a proper diagnosis of the case revealed to the owner, it greatly increases their appreciation of an efficient veterinary service. Acetonemia occurs as a parturient and post-parturient disease in wellnourished, high milk-producing cows. Cows of any breed that are good milk producers may be affected regardless of age. It may occur at any time of the year, but is more prevalent in the fall and spring in Canada. The mortality rate is low. The basic etiological factors of the disease are not lnown, but it is quite clear that there is a deranged carbohydrate metabolism, and it is more likely to occur in cows fed an excessively-rich protein concentrate ration. A protein-rich diet stimulates milk production, but if carried beyond reasonable limits may result in the production of so much milk as to lower the required amount of carbohydrate for normal body maintenance and result in a failure to completely oxidize fats. Thus the presence of ketone bodies in the blood and urine. Clinically acetonemia may be divided into two classes of cases. First, those which occur at, or immediately following, parturition; and secondly, those which appear in from ten days to two weeks or later after parturition. My observations of the disease suggest classifying it in another manner also in which three types of cases are seen. (A) A paralytic or milk fever type seen immediately following parturition and about 10%o of our cases are of that nature. (B) A digestive type presenting itself from ten days to as late as six weeks or more after parturition, and this form constitutes about 80%o of the cases encountered. There is usually a history of a sud-
Plaque Erosion: New Insights From the Road Less Travelled.

The exploration of the steps that lead to coronary thrombi needs another chapter. Decades ago, it was found that the majority (≈3 of 4) of lesions underlying lethal thrombi featured a necrotic core into which blood had entered through a severed fibrous cap.1 Sometimes, bits of core material were embedded in the thrombus linking cap rupture and thrombosis closely in time. Like watching a crashed car or a broken plate, it took modest imagination to understand what must have happened. A thin fibrous cap had ruptured, ripping open the lesion, and exposing the thrombogenic core to the hemostatic system. The lack of a credible alternative mechanism that could explain the observed has made it less of a problem that re-enactment of plaque rupture in model systems or formal proof for the sequence of events in humans have been difficult to achieve. Article, see p 31 For the remainder of thrombi that are not formed on ruptured plaques, it is a completely different game. These cases give few signs away about what caused them. Endothelial cells (ECs) at the plaque-thrombus interface are generally absent, leading to the term plaque erosion, and macrophages are rarely conspicuous.2 More notably, neutrophils are often present.3 But, autopsies cannot tell for sure whether the missing endothelium and neutrophil accumulation were the cause or result of thrombosis. This is not an academic question. EC sloughing and neutrophil invasion occur secondarily to stasis-induced venous thrombosis,4 and thrombi precipitated by plaque rupture can produce the appearance of plaque erosion in neighboring segments.2 The idea that erosions are preceded by plaques deprived of large regions of its endothelial lining may thus be far too …
Content-Based Video Segmentation using Statistical Motion Models

We present in this paper an original approach for content-based video segmentation using motion information. The method is generic and does not require any knowledge about the type of the processed video. Its relies on the analysis of the temporal evolution of the dynamic content of the video. The motion content is characterised by a probabilistic Gibbsian modelling of the distribution of local motion-related measurements. The designed statistical framework provides a well formalised similarity measure according to motion activity that we exploit to derive criteria for segmentation decision. Then, the considered merging criteria are sequentially applied between every two successive temporal units of the video to progressively form homogeneous segments in term of motion content. Experiments on real video documents demonstrate the ability of the proposed approach to provide a concise and meaningful overview of a video.
Oncolytic Adenovirus Expressing Monoclonal Antibody Trastuzumab for Treatment of HER2-Positive Cancer

Monoclonal anti-HER2 antibody trastuzumab has significantly improved the survival of patients with HER2-overexpressing tumors. Nevertheless, systemic antibody therapy is expensive, limited in efficacy due to physical tumor barriers, and carries the risk of severe side effects such as cardiomyopathy. Oncolytic viruses mediate cancer-selective transgene expression, kill infected cancer cells while mounting antitumor immune responses, and have recently demonstrated promising efficacy in combination treatments. Here, we armed an oncolytic adenovirus with full-length trastuzumab to achieve effective in situ antibody production coupled with progressive oncolytic cancer cell killing. We constructed an infectivity-enhanced serotype 5 oncolytic adenovirus, Ad5/3-Δ24-tras, coding for human trastuzumab antibody heavy- and light-chain genes, connected by an internal ribosome entry site. Infected cancer cells were able to assemble full-length functional antibody, as confirmed by Western blot, ELISA, and antibody-dependent cell-mediated cytotoxicity assay. Importantly, oncolysis was required for release of the antibody into tumors, providing additional spatial selectivity. Ad5/3-Δ24-tras showed potent in vitro cytotoxicity and enhanced antitumor efficacy over oncolytic control virus Ad5/3-Δ24 or commercial trastuzumab in HER2-positive cancer models in vivo (both P < 0.05). Furthermore, Ad5/3-Δ24-tras resulted in significantly higher tumor-to-systemic antibody concentrations (P < 0.001) over conventional delivery. Immunological analyses revealed dendritic cell activation and natural killer cell accumulation in tumor-draining lymph nodes. Thus, Ad5/3-Δ24-tras is an attractive anticancer approach combining oncolytic immunotherapy with local trastuzumab production, resulting in improved in vivo efficacy and immune cell activation in HER2-positive cancer. Moreover, the finding that tumor cells can produce functional antibody as directed by oncolytic virus could lead to many valuable antitumor approaches. Mol Cancer Ther; 15(9); 2259–69. ©2016 AACR.
Logfile Failure Prediction using Recurrent and Quasi Recurrent Neural Networks

Inumerable man hours are spent waiting for running programs to finish and then debugging them when they crash by analyzing the logfile. Often times logfiles will contain a plethora of text extraneous to debugging, providing for a tedious undertaking. Therefore, we present an application of state-of-the-art natural language processing with neural networks to classify a run’s final outcome prior to it occurring. Variations of pointer sentinel mixed models and quasi-recurrent neural networks were utilized for this task. The implemented models are first benchmarked on WikiText-2 language modeling then trained on NVIDIA logfile data. To demonstrate the model’s ability to classify before the run ends, F1 scores are plotted against proportion of logfile consumed and are compared to a TF-IDF baseline.
On transverse energy production in hadron collisions

The transverse energy spectrum in the unit rapidity window in p-bar p collisions at 540 GeV c.m. s energy is calculated to the next-to-leading order accuracy O(a_s^3) and compared to the experimental data by UA(2) collaboration. We show that the calculated spectrum starts matching experimental data only at relatively large transverse energy Et=60 GeV and is in essential disagreement with it both in shape and magnitude at lower transverse energies. The data are well reproduced by HIJING Monte-Carlo generator indicating the crucial importance of all-order effects in perturbation theory as well as those of hadronization in describing the transverse energy production in hadron collisions at small and intermediate transverse energies.
Performance Engineering in Agent-based Systems Concepts, Modelling and Examples

This paper presents a kind of application of the software performance engineering to the area of agent-based systems. In a first part we will describe the general aspects and contents of multi agent systems (MAS) architectures. Then, a short presentation of the main software performance principles should motivate the measurement approaches for the MAS. Software agents can be intelligent as well as flexible. This involves the possibility of using traditional methods of software performance evaluation and controlling based on some classical approaches like “a posteriori” or “fix it later” technologies. Our paper presents new approaches in performance measurement of agent-based systems relating to software aglets and MAS based on the new MALINA concept.