Miracle-dz/UniFAR-FTUs huggingface dataset:
Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators.

CONTEXT Raloxifene hydrochloride, a selective estrogen receptor modulator, prevents bone loss in postmenopausal women, but whether it reduces fracture risk in these women is not known. OBJECTIVE To determine the effect of raloxifene therapy on risk of vertebral and nonvertebral fractures. DESIGN The Multiple Outcomes of Raloxifene Evaluation (MORE) study, a multicenter, randomized, blinded, placebo-controlled trial. SETTING AND PARTICIPANTS A total of 7705 women aged 31 to 80 years in 25 countries who had been postmenopausal for at least 2 years and who met World Health Organization criteria for having osteoporosis. The study began in 1994 and had up to 36 months of follow-up for primary efficacy measurements and nonserious adverse events and up to 40 months of follow-up for serious adverse events. INTERVENTIONS Participants were randomized to 60 mg/d or 120 mg/d of raloxifene or to identically appearing placebo pills; in addition, all women received supplemental calcium and cholecalciferol. MAIN OUTCOME MEASURES Incident vertebral fracture was determined radiographically at baseline and at scheduled 24- and 36-month visits. Nonvertebral fracture was ascertained by interview at 6-month-interim visits. Bone mineral density was determined annually by dual-energy x-ray absorptiometry. RESULTS At 36 months of the evaluable radiographs in 6828 women, 503 (7.4%) had at least 1 new vertebral fracture, including 10.1% of women receiving placebo, 6.6% of those receiving 60 mg/d of raloxifene, and 5.4% of those receiving 120 mg/d of raloxifene. Risk of vertebral fracture was reduced in both study groups receiving raloxifene (for 60-mg/d group: relative risk [RR], 0.7; 95% confidence interval [CI], 0.5-0.8; for 120-mg/d group: RR, 0.5; 95% CI, 0.4-0.7). Frequency of vertebral fracture was reduced both in women who did and did not have prevalent fracture. Risk of nonvertebral fracture for raloxifene vs placebo did not differ significantly (RR, 0.9; 95% CI, 0.8-1.1 for both raloxifene groups combined). Compared with placebo, raloxifene increased bone mineral density in the femoral neck by 2.1 % (60 mg) and 2.4% (120 mg) and in the spine by 2.6% (60 mg) and 2.7% (120 mg) P<0.001 for all comparisons). Women receiving raloxifene had increased risk of venous thromboembolus vs placebo (RR, 3.1; 95% CI, 1.5-6.2). Raloxifene did not cause vaginal bleeding or breast pain and was associated with a lower incidence of breast cancer. CONCLUSIONS In postmenopausal women with osteoporosis, raloxifene increases bone mineral density in the spine and femoral neck and reduces risk of vertebral fracture.
An implementation of MIMO InSAR without transmitting orthogonal signals

The ability of MIMO InSAR to reconstruct the terrain height profile would outperform the ordinary multibaseline InSAR. One key of implementing MIMO InSAR is the echo separation on the receiving end. However, the available orthogonal signals would introduce severe cross-interference due to their inadequate orthogonality for imaging. A feasible implementation of MIMO InSAR is presented in this paper, in which the antennas of MIMO InSAR would emit signals alternately in different pulse repetition intervals. Thus, the mainlobe echoes of signals transmitted by different antennas would return in different pulse repetition intervals coordinately, which implies the cross-interference could be suppressed sufficiently even with non-orthogonal transmitting signals as long as a low-sidelobe antenna is employed. The performance of the proposed implementation is proved via numerical simulations.
A Comparison of Process Ontology Discovery from Organizational Guidelines in Two Different Languages

Process ontologies contain organization's process elements which are related to the business activities, in a structured format. Once organizations establish process ontologies, searching process information as well as discovery, modeling and automation become more efficient. Process ontologies are frequently developed from organizational resources such as guidelines, regulations and procedures by interpreting the document, discovering the process information and building the ontology. The studies depict that the development of process ontologies can be partially automated. However, a significant success factor in this automation is the language of the document and the tools available to interpret the written text in a given language. In this study, we conducted an exploratory case study in order to analyze the potential of process ontology discovery in different languages. We applied the process ontology discovery method we have developed for guidelines written in English and Turkish and compared the success rates. We also discuss the requirements for process discovery automation.
A CMOS 3.3-8.4 GHz wide tuning range, low phase noise LC VCO

A novel inductor switching technique is used to design and implement a wideband LC voltage controlled oscillator (VCO) in 0. 13µm CMOS. The VCO has a tuning range of 87.2% between 3.3 and 8.4 GHz with phase noise ranging from −122 to −117.2 dBc/Hz at 1MHz offset. The power varies between 6.5 and 15.4 mW over the tuning range. This results in a Power-Frequency-Tuning Normalized figure of merit (PFTN) between 6.6 and 10.2 dB which is one of the best reported to date.
Trastornos de la personalidad y placa aterosclerótica coronaria: una nueva perspectiva Personality Disorders and Coronary Atherosclerotic Plaque: A New Perspective

El trabajo de Suarez-Bagnasco y colaboradores, que se publica en este numero de la Revista, (1) no solo es un aporte innovador y original, sino que ademas tiene considerable valor clinico. Con un lenguaje sencillo de especialistas en el area de las neurociencias y la psicoinmunoendocrinologia caracterizan las diferentes alteraciones de la personalidad y la relacion de algunos tipos de ellas con la presencia de placas ateroscleroticas en el territorio coronario, e incluso presentan hipotesis sobre los posibles mecanismos fisiopatologicos involucrados. Hasta el presente se ha escrito mucho sobre la relacion existente entre ciertos tipos de personalidad y diferentes complicaciones cardiovasculares, como tambien la evolucion de los pacientes. Sin embargo, aun cuando la evidencia ha sido claramente significativa en algunos trabajos, es raro que en la practica habitual se acepte la relacion entre los factores psicosociales y la enfermedad cardiovascular como un argumento cientificamente sustentable. Por lo regular se senala la dificultad de mensurar con precision la enfermedad psicologica como una noxa definida o las consecuencias a este nivel de los aspectos psicosociales, con un sustento fisiopatologico para poder relacionarlos con la enfermedad cardiovascular. Hoy en dia hay probada evidencia de que estos argumentos cada vez tienen menos validez. (2) Actualmente, conceptos como alostasis, red alostatica y carga alostatica establecieron una conexion entre las neurociencias y la cardiologia, pues la red alostatica es un suprasistema que relaciona al sistema neurovegetativo, el eje hipotalamo-hipofiso-suprarrenal y el sistema inmunitario, y entre sus efectores se encuentra el sistema cardiovascular. (3) Estas son areas familiares para el cardiologo, que puede relacionarlas entre si desde una perspectiva diferente y asi comprender el desarrollo de los factores de riesgo, como el sindrome metabolico o el desarrollo de aterosclerosis en conexion con el sistema nervioso central y las respuestas de este al estres y como diferentes patologias psicologicas o aspectos psicosociales impactan a nivel cardiovascular (4, 5) (Figura 1). En este sentido, el trabajo de Suarez-Bagnasco y colaboradores es innovador, pues enfoca las etapas tempranas de ambos procesos: los trastornos de la personalidad y la aterosclerosis coronaria antes del evento cardiaco.
Indicadores de condições para criar no ambiente de trabalho: evidências de validação empírica de uma medida

The purpose of this article is to provide a quantitative measure of the favorable and unfavorable conditions for creativity in the workplace, conceived as a production process of new ideas and value for a particular work context. We decided to initially improve an already validated instrument with similar purposes. The implementation of the survey to validate the new measure, comprised of 63 items, was made on a sample of 409 analysts of a Brazilian research organization. Semantics and judges analyses were performed, with subsequent factor and reliability analysis of the items. Two different scales were obtained: one that contained six factors expressing favorable conditions and three depicting unfavorable conditions for the expression of creativity in the workplace. The instrument was named Indicators of Conditions to Create in the Workplace (ICCW) and shows up as a robust and updated measure, with the reduction from 97 to 60 items, with high factor loadings, as well as higher reliability scores than the previous measure. The total variance explained index was above 50%. Future applications are suggested in order to check whether the factorial structure is confirmed. We highlight the relevance of making this tool available for use in future research, as well as for organizational diagnosis.
Fatty Acid-binding Proteins Transport N-Acylethanolamines to Nuclear Receptors and Are Targets of Endocannabinoid Transport Inhibitors*

Background: Transport inhibitors modulate endocannabinoid signaling by inhibiting their uptake through unknown mechanisms. Results: Effects of transport inhibitors upon endocannabinoid uptake and intracellular trafficking were lost in the absence of fatty acid-binding proteins. Conclusion: Fatty acid-binding proteins are physiological targets of transport inhibitors. Significance: These findings identify drug targets for modulating endocannabinoid signaling. N-Acylethanolamines (NAEs) are bioactive lipids that engage diverse receptor systems. Recently, we identified fatty acid-binding proteins (FABPs) as intracellular NAE carriers. Here, we provide two new functions for FABPs in NAE signaling. We demonstrate that FABPs mediate the nuclear translocation of the NAE oleoylethanolamide, an agonist of nuclear peroxisome proliferator-activated receptor α (PPARα). Antagonism of FABP function through chemical inhibition, dominant-negative approaches, or shRNA-mediated knockdown reduced PPARα activation, confirming a requisite role for FABPs in this process. In addition, we show that NAE analogs, traditionally employed as inhibitors of the putative endocannabinoid transmembrane transporter, target FABPs. Support for the existence of the putative membrane transporter stems primarily from pharmacological inhibition of endocannabinoid uptake by such transport inhibitors, which are widely employed in endocannabinoid research despite lacking a known cellular target(s). Our approach adapted FABP-mediated PPARα signaling and employed in vitro binding, arachidonoyl-[1-14C]ethanolamide ([14C]AEA) uptake, and FABP knockdown to demonstrate that transport inhibitors exert their effects through inhibition of FABPs, thereby providing a molecular rationale for the underlying physiological effects of these compounds. Identification of FABPs as targets of transport inhibitors undermines the central pharmacological support for the existence of an endocannabinoid transmembrane transporter.
The relationship of aerobic exercises and body weight reduction among regular physical fitness participants

This study was aimed to examine the relationship of aerobic exercises and body weight reduction among regular physical fitness participants. The researcher used longitudinal experimental research design because participants were tested more than once test and trained for 12 weeks. Twenty subjects were purposively selected as a subject and randomly assigned in high intensity and moderate intensity group; whose age is in between twenty up to fifty years old and their body mass index (BMI) is 25kg/m2 and above. Both groups participated in high intensity and moderate intensity aerobics exercise in their respective groups three days per week for three consecutive months. Pre, during and post tests were taken accordingly to examine the improvements in each variables such as body weight, body mass index, waist circumference, hip circumference and waist hip ratio. Paired sample T-tests indicated a significant reduction of BWt and BMI in both groups of female and male participants at p-value (p < 0.01). Based on the results, it was concluded that both moderate intensity and high intensity aerobics exercise group had a positive effect on body weight reduction. It showed that aerobic exercise has a positive relationship on body weight reduction. Finally, the researcher recommends that regular aerobic exercise is a better means to reduce body weight.
NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin‐releasing hormone gene expression.

The key roles of the excitatory neurotransmitter glutamate and its second messengers, nitric oxide (NO) and cGMP, in long‐term potentiation and neural plasticity are well documented. However, complex functions such as memory are likely to require long term changes in synaptic efficacy which require gene expression and protein synthesis. Here we demonstrate that the glutamate receptor agonist, N‐methyl‐D‐aspartic acid (NMDA), nitric oxide (NO) and cGMP each repress expression of the gonadotropin‐releasing hormone (GnRH) gene in the hypothalamic cell line, GT1. This repression is dependent upon signals from NMDA receptors activating NO synthase to synthesize NO. In turn NO induces guanylyl cyclase to synthesize cGMP, activating cGMP‐ dependent protein kinase. Repression requires elevation of calcium because it only occurs in the presence of calcium ionophore or with release of intracellular calcium. Repression also requires protein synthesis. Activation of this pathway specifically represses expression of a reporter gene containing the regulatory region of the GnRH gene in transfected GT1 cells, indicating that repression occurs at the transcriptional level. Furthermore the target for transcriptional repression is a 300 bp neuron‐specific enhancer found 1.5 kb upstream of the GnRH gene which is sufficient to confer repression to a heterologous promoter. Thus the NMDA/NO/cGMP neurotransmitter signal transduction pathway controls not only synaptic function but also neuron‐specific gene expression.
Do parallel languages respond to the needs of scientific programmers?

Parallel programming is considered from the viewpoint of scientific researchers, with particular reference to their requirements for language support. The questions of how scientists go about developing parallel applications, what role language plays in determining the success of their programming efforts, how much scientific programmers should be expected to know about parallel languages and machines and what computer scientists can do to facilitate parallel scientific programming are addressed. The discussion centers on the 'mainline' supercomputers for scientific and engineering applications: vector and scalar MIMD (multiple instruction, multiple data) multiprocessors. New research efforts that are tackling the problems facing scientific programmers are discussed. <<ETX>>
School performance and alcohol-related disorders in early adulthood: a Swedish national cohort study

Background Alcohol misuse is an important global health determinant and a major contributor to health inequalities. We aimed to investigate the association between school performance and alcohol-related disorders in early adulthood in a longitudinal register-based national cohort study. Methods We followed a register-based national cohort of Swedish citizens born 1973–1984 (N = 948 440) from compulsory school graduation at age 15–16 to 2009. We divided the population into five groups: high school marks (> mean + 1 SD); high average (between mean and mean + 1 SD); low average (between mean and mean − 1 SD); low (< mean – 1SD); and missing. Cox proportional hazard models were used to investigate the relation between school marks at time of graduation and hospital care for alcohol-related disorders in early adulthood. Results There was a steep gradient in the risk of alcohol-related disorders related to school performance. In comparison with peers in the top category of school marks, students with low marks had adjusted hazard ratios of 8.02 [95% confidence interval (CI) 7.20 to 8.91], low average 3.02 (2.72 to 3.35) and high average 1.55 (1.39 to 1.73). The risk associated with low school marks was stronger in the male population and in the group from high socioeconomic background. Conclusions The study demonstrated a strong graded relation between low school performance and alcohol-related disorders in young adulthood. School performance should be taken into account when developing prevention programmes/policies targeting alcohol misuse among teenagers and young adults, especially if the aim is to reach high-risk groups.
Metastatic Gastroesophageal Adenocarcinoma Patients Treated with Systemic Therapy Followed by Consolidative Local Therapy: A Nomogram Associated with Long-Term Survivors

Objective: Patients with metastatic gastroesophageal adenocarcinoma (MGEAC) have a poor but heterogeneous clinical course. Some patients have an unusually favorable outcome. We sought to identify clinical variables associated with more favorable outcomes. Methods: Of 246 patients with MGEAC, we identified 64 who received systemic therapy and eventually received local consolidation therapy. Univariate and multivariate Cox regression models were used, and a nomogram was developed. Results: Of these 64 patients, 61% had received consolidation chemoradiation (CRT) with doses of 50-55 Gy and 78% did not undergo surgery. The median follow-up time of survivors was 3.9 years, and the median overall survival (OS) from CRT start was 1.5 years (95% CI, 1.2-2.2). Surgery (as local consolidation) was an independent prognosticator for longer OS in the multivariate analysis (p = 0.02). The 5-year OS rate was 25% (SE = 6%). The contributors to the nomogram were longer duration of systemic therapy before CRT and the type of local therapy. Conclusions: Our data suggest that a subset of patients with MGEAC have an excellent prognosis (OS >5 years). However, these patients need to be identified during their clinical course so that local consolidation (CRT, surgery, or both) may be offered.
A Mediation Strategy for Special Education Disputes

The use of mediation in the resolution of disputes is not new to American society. It is new, however, in the realm of special education as a strategy for problem solving before a disagreement between parents and a school district escalates to the point of necessitating a due process hearing. As a result of the IDEA Amendments of 1997, mediations are now required to be offered as interventions in every state. Missouri, ahead of the regulation, began offering mediations in the fall of 1996. It is the purpose of this article to discuss the successes and challenges associated with mediations as they have occurred because of their brief history in Missouri, with a pointed examination of four specific cases.
The effect of cottonseed components on testicular development in pubescent rams.

The effect of gossypol on testicular development in rams was examined using 2 experimental approaches. Trial I utilized direct ruminal deposition of gossypol acetic acid (GAA; 95% purity), whereas Trial II compared 2 types of dietary cottonseed, regular and glandless. For Trial I, 18 Polypay or Polypay x Dorset ram lambs, aged 4 to 6 mo, were surgically fitted with rumen cannulae. These 18 ram lambs were divided into groups of 6 which were given either 0, 2.2 or 6.6 mg of GAA/kg body weight daily via gelatin capsules directly into the rumen. All rams in Trial I were slaughtered after 4 or 8 w of treatment to allow recovery of their scrotal contents. The mean testicular weight for the group of rams given 6.6 mg GAA/kg/d was 8% (p less than .05) less than for the rams given 0 mg GAA/kg/d. The caudal epididymal sperm were examined microscopically for percentage of progressively motile sperm and flow cytometrically for mitochondrial function using rhodamine 123 (R123). Differences in sperm motility were not evident among the treatment groups, nor were differences detectable in the 2 major sperm populations, B and C, that were identified by flow cytometry. In Trial II, 21 Polypay and Polypay-Dorset ram lambs, aged 10 mo, were randomly assigned into 3 groups (n = 7) and fed either glandless fuzzy cottonseed (GFC), glandless flake cottonseed (GFL) or regular fuzzy cottonseed (RFC). All rams were fed for 5 w a total daily ration (TDR) equivalent to 3.5% of their body weight daily with 25% being cottonseed. After 8 w the scrotal contents were recovered by castration. (ABSTRACT TRUNCATED AT 250 WORDS)
Hybrid Content and Tag-based Profiles for Recommendation in Collaborative Tagging Systems

Collaborative tagging systems have grown in popularity over the Web in the last years on account of their simplicity to categorize and retrieve content using open-ended tags. The increasing number of users providing information about themselves through social tagging activities caused the emergence of tag-based profiling approaches, which assume that users expose their preferences for certain contents through tag assignments. On the other hand, numerous content-based profiling techniques have been developed to address the problem of obtaining accurate models of user information preferences in order to assist users with information-related tasks such as Web browsing or searching. In this paper we propose a hybrid user profiling strategy that takes advantage of both content-based profiles describing long-term information interests that a recommender system can acquired along time and interests revealed through tagging activities, with the goal of enhancing the interaction of users with a collaborative tagging system. Experimental results of using hybrid profiles for tag recommendation are reported and possible applications of these profiles for obtaining personalized recommendations in collaborative tagging systems are discussed.
MICROWAVE THERMOGRAPHY FOR CANCER DETECTION

The paper presents some new methods for early breast cancer detection using microwaves. On describe the following methods and techniques: microwave impedance tomography, termography and microwave radiometry, combined methods microwave and ultra-acustic image and confocal microwave imaging. We make an analysis of advantages and disadvantages of every method and also physical principles of microwave thermography.
Influence of Riverbed Change on a Possibility of Flooding During Water Level Rise of the River Kura

The study of floods by remote sensing data and GIS technology is necessary for the rapid detection of floods in the populated areas, provision of an early evacuation of the population and implementing correct response measures. This paper has been dedicated to studying the methodology of flood mapping by GIS technology on the basis of processing the taken by Earth observation satellite “AZERSKY/SPOT-6” for the period of 2014-2016. Flood-prone areas at river Kura, Khrami and Debed were identified using software package ENVI 5.2 and ArcGIS version 10.4. 1. The initial images have been received in the project «Promotion of Earth remote surveillance services for the sake of sustainable development of Azerbaijan» of Azercosmos OJSCo. This research has been carried out on the basis of software and methodological support of «Processing of the aerospace information» sector of «Aerospace Monitoring» within «Aerospace Monitoring of the Environment» department of National Aviation Academy.