Miracle-dz/UniFAR-FTUs huggingface dataset:
Doppler imaging of the double-lined active binary V824 Ara

We introduce an iterative spectral disentangling technique combined with Doppler imaging in order to recover surface temperature maps for both components of double-lined active binary systems. Our method provides an opportunity to separate spectra of the active components while minimizing the unwanted disturbances on the given line profile from the other component. The efficiency of the method is demonstrated on real data of the double-lined RS CVn-type binary V824 Ara. The resulting Doppler images reveal cool spots on the polar regions as well as low-latitude features on both of the stars. Moreover, both components have hot spots, that are facing each other. This may indicate interconnection between the stellar magnetic fields.
Generic Outcomes of Observational Learning

This paper analyzes a generalized version of the sequential social learning model. We focus on perfect learning, a stronger equilibrium property than the asymptotic learning property analyzed in the literature. Our aim is to characterize the environments in which perfect learning occurs. We allow the state space to be compact metric and show that, generically in the space of continuous utility functions, perfect learning holds if the private signals are conditionally independent and the action space perfect. Therefore, failure of perfect learning, and hence the occurrence of informational cascades, is a non generic phenomenon if the action space is rich. Finally, we provide a result with implications for Bayesian decision making and the observational learning literature in general.
A Smoothed- Distribution Form of Nadaraya- Watson Estimation

Given observation-pairs (xi ,yi ), i = 1,. ,n , taken to be independent observations of the random pair (X ,Y), we sometimes want to form a nonparametric estimate of m(x) = E(Y/ X = x). Let YE have the empirical distribution of the yi , and let (XS ,YS ) have the kernel-smoothed distribution of the (xi ,yi ). Then the standard estimator, the Nadaraya-Watson form mNW(x) can be interpreted as E(YE? XS = x). The smoothed-distribution estimator ms (x)=E(YS/XS = x) is a more general form than mNW (x) and often has better properties. Similar considerations apply to estimating Var(Y/X = x), and to local polynomial estimation. The discussion generalizes to vector (xi ,yi ).
Pseudophakia and Lens Opacities in 70-Year-Olds in Gothenburg, Sweden; Gender Differences, Impact on Self-Reported Visual Function and Validation of Self-Reported Cataract and Pseudophakia

Purpose The study aimed at determining the prevalence and sex differences in cataract, pseudophakia, lens opacities and self-reported cataract in 70-year-old people in Gothenburg, Sweden. The purpose was also to identify correlations between lens opacities, visual acuity and subjective visual function, and to validate self-reported cataract and cataract surgery. Patients and Methods Population-based cross-sectional study where participants (n=1182) answered questions about self-reported diagnosis of cataract and cataract surgery. A total of 1139 subjects completed the National Eye Institute Visual Functioning Questionnaire‐25 (NEI VFQ‐25), 560 subjects underwent ophthalmic examination including visual acuity and lens photography. t-test, Pearson chi-square and Mann–Whitney U-test were used for obtaining p-values. ANOVA (analysis of variances, Kruskal–Wallis, one-way) was used to compare VFQ-25 between 3 groups; no cataract, cataract and pseudophakia. To clarify the differences between specific pairs of groups post-hoc test (Bonferroni) was used after ANOVA. Results Self-reported cataract was more common in women than in men (27.2% vs 19.1%, p=0.001, chi-square). Cataract surgery was reported by 16.3% of women and 12.6% of men (p=0.072). Upon eye examination, the prevalence of pseudophakia was 16.9% in women compared to 10.2% in men (p=0.020). The prevalence of cataract, including pseudophakia, was 31.9% in women versus 23.8% in men (p=0.033). Significant correlations (Spearman’s rho) were found between lens opacities and visual acuity. Self-reported cataract surgery showed a very high specificity and high sensitivity. The composite score from NEI VFQ‐25 was lower in people with pseudophakia than in people with/without cataract (p=0.012, Kruskal–Wallis). Conclusion The prevalence of cataract including pseudophakia in 70-year-olds in Gothenburg is higher compared to previous studies in similar geographical areas. Also, it is more common in women than in men. The lack of significant sex differences in lens opacities may be due to cataract surgery at an earlier stage. Validation showed very good agreement between pseudophakia and self-reported cataract surgery.
Pandemic, Politics, and Public Opinion About Crime

Prior scholarship links ontological insecurities, racial tensions, and health issues to public opinion about crime. This project examined these forces in the context of the 2020 pandemic, racial justice demonstrations, and politics using data from the Nebraska 2020 survey (N = 2775). Pandemic-related insecurities and racial animus were associated with avoiding places in the community, worry about crime, and the belief that police in one's community are underfunded. Trusting politicians but distrusting health leaders, and viewing COVID as an economic threat but not a health threat were associated with the belief police are underfunded. Results suggest that the politicization of the pandemic may influence support for criminal justice policies that promise a return to “law and order. ”
Radiation induced lung injury (RILI) after postoperative intensity modulated proton therapy (IMPT) in a patient with stage III locally advanced lung adenocarcinoma: a case report

Background Postoperative radiation therapy (PORT) remains the critical therapy for stage III non-small cell lung cancer (NSCLC). Radiation induced lung injury (RILI) is common and affects the clinical outcome. Proton therapy (PT) is a new-style radiotherapy with accurate distribution of curative dose to tumor and increased organ-at-risk (OAR) sparing, which potentially decrease the incidence of RILI. Intensity modulated proton therapy (IMPT) is more flexible and conformal one. Case Description In the case, we report a 47-year-old man with stage III locally advanced lung adenocarcinoma developing RILI after IMPT. The man had no chronic pulmonary disease before. After 6 cycles every three-week of postoperative adjuvant chemotherapy (pemetrexed, carboplatin), he sequentially received 50 GyE of IMPT in 25 fractions. About 7 weeks after IMPT, grade 2 RILI was developed with the manifestation of focal pulmonary consolidation and ground-glass attenuation. Steroid therapy was delivered and the pneumonias absorbed slightly with chronic scarring and fibrosis left over. Conclusions RILI after IMPT is not commonplace especially under the circumstance where the patient had no chronic lung disease and the proton dose was conservative. The patient manifested as the early developed acute exudation and fibrosis stage. Moreover, the injury was so refractory that fibrosis was developing in spite of active steroid therapy. Based on the case, we suggested that more exploration of proton induced lung injury and evaluation before IMPT especially following chemotherapy are deserved.
INFALLING–ROTATING MOTION AND ASSOCIATED CHEMICAL CHANGE IN THE ENVELOPE OF IRAS 16293–2422 SOURCE A STUDIED WITH ALMA

We have analyzed rotational spectral line emission of OCS, CH3OH, HCOOCH3, and H2CS observed toward the low-mass Class 0 protostellar source IRAS 16293–2422 Source A at a sub-arcsecond resolution (∼0.″6 × 0.″5) with ALMA. Significant chemical differentiation is found on a scale of 50 au. The OCS line is found to trace well the infalling–rotating envelope in this source. On the other hand, the distributions of CH3OH and HCOOCH3 are found to be concentrated around the inner part of the infalling–rotating envelope. With a simple ballistic model of the infalling–rotating envelope, the radius of the centrifugal barrier (a half of the centrifugal radius) and the protostellar mass are evaluated from the OCS data to be from 40 to 60 au and from 0.5 to 1.0 M⊙, respectively, assuming the inclination angle of the envelope/disk structure to be 60° (90° for the edge-on configuration). Although the protostellar mass is correlated with the inclination angle, the radius of the centrifugal barrier is not. This is the first indication of the centrifugal barrier of the infalling–rotating envelope in a hot corino source. CH3OH and HCOOCH3 may be liberated from ice mantles by weak accretion shocks around the centrifugal barrier and/or by protostellar heating. The H2CS emission seems to come from the disk component inside the centrifugal barrier in addition to the envelope component. The centrifugal barrier plays a central role not only in the formation of a rotationally supported disk but also in the chemical evolution from the envelope to the protoplanetary disk.
DEVELOPMENT OF THE MODEL OF GALACTIC INTERSTELLAR EMISSION FOR STANDARD POINT-SOURCE ANALYSIS OF FERMI LARGE AREA TELESCOPE DATA

Most of the celestial γ rays detected by the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope originate from the interstellar medium when energetic cosmic rays interact with interstellar nucleons and photons. Conventional point-source and extended-source studies rely on the modeling of this diffuse emission for accurate characterization. Here, we describe the development of the Galactic Interstellar Emission Model (GIEM), which is the standard adopted by the LAT Collaboration and is publicly available. This model is based on a linear combination of maps for interstellar gas column density in Galactocentric annuli and for the inverse-Compton emission produced in the Galaxy. In the GIEM, we also include large-scale structures like Loop I and the Fermi bubbles. The measured gas emissivity spectra confirm that the cosmic-ray proton density decreases with Galactocentric distance beyond 5 kpc from the Galactic Center. The measurements also suggest a softening of the proton spectrum with Galactocentric distance. We observe that the Fermi bubbles have boundaries with a shape similar to a catenary at latitudes below 20° and we observe an enhanced emission toward their base extending in the north and south Galactic directions and located within ∼4° of the Galactic Center.
YOUNG SOLAR SYSTEM's FIFTH GIANT PLANET?

Studies of solar system formation suggest that the solar system's giant planets formed and migrated in the protoplanetary disk to reach the resonant orbits with all planets inside ∼15 AU from the Sun. After the gas disk's dispersal, Uranus and Neptune were likely scattered by the gas giants, and approached their current orbits while dispersing the transplanetary disk of planetesimals, whose remains survived to this time in the region known as the Kuiper Belt. Here we performed N-body integrations of the scattering phase between giant planets in an attempt to determine which initial states are plausible. We found that the dynamical simulations starting with a resonant system of four giant planets have a low success rate in matching the present orbits of giant planets and various other constraints (e.g., survival of the terrestrial planets). The dynamical evolution is typically too violent, if Jupiter and Saturn start in the 3:2 resonance, and leads to final systems with fewer than four planets. Several initial states stand out in that they show a relatively large likelihood of success in matching the constraints. Some of the statistically best results were obtained when assuming that the solar system initially had five giant planets and one ice giant, with the mass comparable to that of Uranus and Neptune, and which was ejected to interstellar space by Jupiter. This possibility appears to be conceivable in view of the recent discovery of a large number of free-floating planets in interstellar space, which indicates that planet ejection should be common.
Phylogenetically under‐dispersed gut microbiomes are not correlated with host genomic heterozygosity in a genetically diverse reptile community

While key elements of fitness in vertebrate animals are impacted by their microbiomes, the host genetic characteristics that factor into microbiome composition are not fully understood. Here, we correlate host genomic heterozygosity and gut microbiome phylogenetic diversity across a community of reptiles in southwestern New Mexico to test hypotheses about the behaviour of host genes that drive microbiome assembly. We find that microbiome communities are phylogenetically under‐dispersed relative to random expectations, and that host heterozygosity is not correlated with microbiome diversity. Our analyses reinforce results from functional genomic work that identify conserved host immune and nonimmune genes as key players in microbiome assembly, rather than gene families that rely on heterozygosity for their function.
Blind source separation of speech and music signals using harmonic frequency dependent independent vector analysis

Proposed is an advanced frequency dependence model for independent vector analysis (IVA) by introducing a harmonic clique model. The proposed model considers the harmonic structure of speech and music signals by assigning strong dependencies among multiples of fundamental frequencies. The proposed model is more effective in separating music and speech signals than both the original IVA and the sub-band local clique IVA.
An N-glycan on the C2 domain of JAGGED1 is important for Notch activation

The canonical members of the Jagged/Serrate and Delta families of transmembrane ligands have an extracellular, amino-terminal C2 domain that binds to phospholipids and is required for optimal activation of the Notch receptor. Somatic mutations that cause amino substitutions in the C2 domain in human JAGGED1 (JAG1) have been identified in tumors. We found in reporter cell assays that mutations affecting an N-glycosylation site reduced the ligand’s ability to activate Notch. This N-glycosylation site located in the C2 domain is conserved in the Jagged/Serrate family but is lacking in the Delta family. Site-specific glycan analysis of the JAG1 amino terminus demonstrated that occupancy of this site by either a complex-type or high-mannose N-glycan was required for full Notch activation in reporter cell assays. Similarly to JAG1 variants with defects in Notch binding, N-glycan removal, either by mutagenesis of the glycosylation site or by endoglycosidase treatment, reduced receptor activation. The N-glycan variants also reduced receptor activation in a Notch signaling–dependent vascular smooth muscle cell differentiation assay. Loss of the C2 N-glycan reduced JAG1 binding to liposomes to a similar extent as the loss of the entire C2 domain. Molecular dynamics simulations suggested that the presence of the N-glycan limits the orientation of JAG1 relative to the membrane, thus facilitating Notch binding. These data are consistent with a critical role for the N-glycan in promoting a lipid-binding conformation that is required to orient Jagged at the cell membrane for full Notch activation. Description N-Glycosylation of JAGGED1 is required for optimal activation of Notch. Sweetening Notch activation by Jagged Activation of the transmembrane receptor Notch by ligands of the Jagged/Serrate and Delta families specifies cell fate in many contexts. The phospholipid-binding C2 domain in these ligands contributes to Notch activation by providing both cell membrane and Notch interaction sites. Meng et al. discovered that efficient phospholipid binding and Notch activation by human Jagged1 (JAG1) required N-glycosylation of the membrane-interacting face of the C2 domain at a site that is highly conserved only in Jagged/Serrate ligands. Cancer-associated and engineered mutations that abrogated glycosylation of this domain or enzymatic removal of the glycan reduced JAG1-mediated Notch activation in reporter cells, and the effects of the mutations were recapitulated in an in vitro cellular differentiation assay. Molecular dynamics simulations suggested a model in which the N-glycan promotes an orientation of JAG1 at the cell membrane that poises it for interaction with Notch. Thus, glycosylation of JAG1 ensures optimal activation of Notch.
Guided Spin Waves

Patterned ferromagnetic magnetic thin films of submicron size can serve as waveguides for spin waves. This chapter emphasizes the interaction of spin waves with magnetic domain walls for the case of propagating spin waves in thin magnetic strips. The study is based on micromagnetic simulations. It is shown that by manipulating the phase of propagating spin waves and by combining magnetic strips in patterned thin-film elements, spin waves can be used for logical operations. A typical device is a magnetic interferometer where spin waves split along different paths and then are recombined to produce constructive or destructive interference, depending on the magnetic structures of the separate paths. Simulations show that 360° domain walls can produce phase shifts of 180°. The calculations are carried out using the dynamic Landau–Lifshitz–Gilbert integro-differential equations of micromagnetism with finite elements. The finite-element method greatly reduces the computational artifacts that can arise from the discretization, especially in this case where patterned elements with curved surfaces are modeled. Results are shown for stripes, tuning forks, and interferometer patterns as an introduction to the basic elements of spin-wave logics. The phase shifts of the spin waves are of fundamental interest and provide an instructive example of the concept of Berry phases in magnetism. Keywords: spin-wave logics; propagating spin waves; phase shift; domain walls; finite-element method; magnetic thin-film elements; micromagnetic modeling
Role of mutual information in entropy production under information exchanges

We relate the information exchange between two stochastic systems to the nonequilibrium entropy production in the whole system. By deriving a general formula that decomposes the total entropy production into the thermodynamic and informational parts, we obtain nonequilibrium equalities such as the fluctuation theorem in the presence of information processing. Our results apply not only to situations under measurement and feedback control but also to those under multiple information exchanges between two systems, giving the fundamental energy cost for information processing and elucidating the thermodynamic and informational roles of a memory in information processing. We point out a dual relationship between measurement and feedback.
Impact of Tenofovir Disoproxil Fumarate Use During Pregnancy on Maternal Bone Mineral Density

systematically We conducted a phase II randomized controlled trial (RCT) in Guangxi Zhuang Autonomous Region of the People’s Republic of China, to evaluate the bone mineral density (BMD) effects of TDF on women and their infants. Effects of TDF on bone health of infants have been reported elsewhere 3 ; this report presents our findings on the effects of TDF on maternal BMD.
Experiences from a Balint group intervention with urban public school teachers

Background: U.S. teacher shortages have more than tripled since the 2012-2013 school year, to over 110 000 teachers needed in 2016. At the conclusion of the 2011-12 school year, 13.8% of public-school teachers left their position. Approximately 50% of the public-school teachers cited the inability to manage their roles as the primary factor for leaving. Purpose: The purpose of this study was to examine the influence of participation in a 6-month Balint group experience on a novice teacher’s self-efficacy, experience with burnout, and intentions to persist in the classroom. Research Design: A converged mixed-methods approach was used. Each question was explored with a corresponding qualitative and a quantitative dataset. Data Collection: Qualitative data included (a) a semi-structured focus group; (b) field notes shared from the co-facilitator and Balint group leader; (c) semi-structured debriefs with the Balint group leaders; (d) open-ended questions on the pre and post-test reflection forms, and (e) semi-structured interviews with 3 participants that served as a form of member checking. Quantitative data included pre and post-test and monthly reflection forms that were collected at the conclusion of each meeting. Teacher’s self-efficacy, experience with burnout, and intentions to persist in the classroom. Study Sample: Eight teachers volunteered for the group after an email solicitation to all the teacher development program’s members. Results: This article examines sources of stress for new teachers, themes that came up in the Balint group that reflect the stress and its impact, and changes in felt burnout, self-efficacy, an intent to persist in teaching. Teachers faced similar stressors to professionals in the medical field. Conclusion: Balint offers an opportunity to addres the social and emotional needs teachers face.
Effect of Vegetable Host Plant Type on Halyomorpha halys (Hemiptera: Pentatomidae) Nymphal Development

Abstract The brown marmorated stink bug, Halyomorpha halys (Stål), is an invasive pest introduced to North America in the mid-1990's that has caused economic losses to a wide range of commodities. In vegetables, H. halys feeding damage has been well described, but the effect of different vegetable hosts on H. halys fitness is less understood. We caged 2nd instar H. halys on different vegetable hosts (e.g., tomato, sweet corn, eggplant, bell pepper, and snap bean) and monitored their development until adulthood to compare the effects of vegetable host type on H. halys nymph survival and development time. Experiments were replicated nine times over a two-year period. Survival of 2nd instars from F1 generation (early-season) eggs was low (<30%) on all vegetables resulting in no significant treatment effect. However, H. halys nymphs collected from F2 generation (late-season) eggs had higher survivorship on all vegetables except tomato. The percentage of H. halys 2nd instars that reached adulthood was greatest on corn (53%) and pepper (45%), followed by snap bean (24%), and significantly lower on eggplant (9%) and tomato (2%). Total development time from 2nd instar to adult was fastest on corn and slowest on peppers, although tomatoes were not tested due to the low survival. Trends in development rate were not seasonally-dependent. Our study compares H. halys survivability on several vegetable commodities, and provides insights into H. halys developmental success and dependence on various host plants over the season.
Optimizing SARS-CoV-2 Pooled Testing Strategies Through Differentiated Pooling for Distinct Groups

Abstract Pooled testing has been successfully used to expand SARS-CoV-2 testing, especially in settings requiring high volumes of screening of lower-risk individuals, but efficiency of pooling declines as prevalence rises. We propose a differentiated pooling strategy that independently optimizes pool sizes for distinct groups with different probabilities of infection to further improve the efficiency of pooled testing. We compare the efficiency (results obtained per test kit used) of the differentiated strategy to a traditional pooling strategy in which all samples are processed using uniform pool sizes under a range of scenarios. For most scenarios, differentiated pooling is more efficient than traditional pooling. In scenarios examined here, an improvement in efficiency of up to 3.94 results per test kit could be obtained through differentiated versus traditional pooling, with more likely scenarios resulting in 0.12 to 0.61 additional results per kit. Under circumstances similar to those observed in a university setting, implementation of our strategy could result in an improvement in efficiency between 0.03 to 3.21 results per test kit. Our results can help identify settings, such as universities and workplaces, where differentiated pooling can conserve critical testing resources.