Miracle-dz/UniFAR-FTUs huggingface dataset:
Seismic imaging of the Sun's far hemisphere and its applications in space weather forecasting

The interior of the Sun is filled acoustic waves with periods of about 5 min. These waves, called “p modes,” are understood to be excited by convection in a thin layer beneath the Sun's surface. The p modes cause seismic ripples, which we call “the solar oscillations. ” Helioseismic observatories use Doppler observations to map these oscillations, both spatially and temporally. The p modes propagate freely throughout the solar interior, reverberating between the near and far hemispheres. They also interact strongly with active regions at the surfaces of both hemispheres, carrying the signatures of said interactions with them. Computational analysis of the solar oscillations mapped in the Sun's near hemisphere, applying basic principles of wave optics to model the implied p modes propagating through the solar interior, gives us seismic maps of large active regions in the Sun's far hemisphere. These seismic maps are useful for space weather forecasting. For the past decade, NASA's twin STEREO spacecraft have given us full coverage of the Sun's far hemisphere in electromagnetic (EUV) radiation from the far side of Earth's orbit about the Sun. We are now approaching a decade during which the STEREO spacecraft will lose their farside vantage. There will occur significant periods from thence during which electromagnetic coverage of the Sun's far hemisphere will be incomplete or nil. Solar seismology will make it possible to continue our monitor of large active regions in the Sun's far hemisphere for the needs of space weather forecasters during these otherwise blind periods.
Temper, Temperature, and Temptation

In this study, we analyzed data from 57,293 Major League Baseball games to test whether high temperatures interact with provocation to increase the likelihood that batters will be hit by a pitch. Controlling for a number of other variables, we conducted analyses showing that the probability of a pitcher hitting a batter increases sharply at high temperatures when more of the pitcher’s teammates have been hit by the opposing team earlier in the game. We suggest that high temperatures increase retaliation by increasing hostile attributions when teammates are hit by a pitch and by lowering inhibitions against retaliation.
Molecular Docking Studies of Myricetin and Its Analogues against Human PDK-1 Kinase as Candidate Drugs for Cancer

Phosphoinositide-dependent protein kinase-1 (PDK1), the class of serine threonine kinase, is a master regulator of the AGC family of kinases. It is a main component of the PI3K pathway. As it is reported that this pathway is most commonly, and this pathway is the most commonly deregulated among many cancers. So designing a selective inhibitor of PDK1 may have the efficacy as an anticancer agent. Herein, we describe our work focused on the structure based on screening of 95% similar analogues of Myricetin deposited in PubChem database as earlier studies have been suggested that myricetin acts as an anti cancer agent. Further molecular docking as well as the in silico ADMET studies are incorporated on these compounds to evaluate the binding and pharmacokinetic properties of these compounds. Due to low oral bioavailability, clinical use of myricetin is limited. Therefore this study is an attempt towards screening of structurally similar better compounds as compare with myricetin which can act as better inhibitor against PDK-1.
Futiling eavesdropping in harvested energy powered cognitive radio networks under secrecy constraints and multi slot spectrum sensing schedule

In this paper, we study optimal spectrum sensing schedule and optimal amount of transmission energy for harvested energy powered cognitive radio networks (CRN). We consider a scenario where cognitive users (CUs) exchange secrete messages in the presence of multiple movable eavesdroppers. The location set of eavesdroppers is modeled by Homogenous Poison Point Process (HPPP). To satisfy the instantaneous interference constraint with primary network, CU transmitters have adaptive power antennas. At the beginning of each time slot, CU transmitter decides to become active to sense channel or remain inactive to transmit if channel is vacant or not, on the basis of remaining energy in battery and expected secrecy transmission rate (ESTR). The purpose of this manuscript is to get future base reward for secrecy transmission rate of CRNs.
Inflammatory cytokines and plasma redox status responses in hypertensive subjects after heat exposure

Hypertension is characterized by a pro-inflammatory status, including redox imbalance and increased levels of pro-inflammatory cytokines, which may be exacerbated after heat exposure. However, the effects of heat exposure, specifically in individuals with inflammatory chronic diseases such as hypertension, are complex and not well understood. This study compared the effects of heat exposure on plasma cytokine levels and redox status parameters in 8 hypertensive (H) and 8 normotensive (N) subjects (age: 46.5±1.3 and 45.6±1.4 years old, body mass index: 25.8±0.8 and 25.6±0.6 kg/m2, mean arterial pressure: 98.0±2.8 and 86.0±2.3 mmHg, respectively). They remained at rest in a sitting position for 10 min in a thermoneutral environment (22°C) followed by 30 min in a heated environmental chamber (38°C and 60% relative humidity). Blood samples were collected before and after heat exposure. Plasma cytokine levels were measured using sandwich ELISA kits. Plasma redox status was determined by thiobarbituric acid reactive substances (TBARS) levels and ferric reducing ability of plasma (FRAP). Hypertensive subjects showed higher plasma levels of IL-10 at baseline (P<0.05), although levels of this cytokine were similar between groups after heat exposure. Moreover, after heat exposure, hypertensive individuals showed higher plasma levels of soluble TNF receptor (sTNFR1) and lower TBARS (P<0.01) and FRAP (P<0.05) levels. Controlled hypertensive subjects, who use angiotensin-converting-enzyme inhibitor (ACE inhibitors), present an anti-inflammatory status and balanced redox status. Nevertheless, exposure to a heat stress condition seems to cause an imbalance in the redox status and an unregulated inflammatory response.
Increasing the flexibility and speed of convergence of a learning agent

A review of the basic methods used to model a learning agent, such as instance-based learning, artificial neural networks and reinforcement learning, suggests that they either lack flexibility (can only be used to solve a small number of problems) or they tend to converge very slowly to the optimal policy. This paper describes and illustrates a set of processes that address these two shortcomings. The resulting learning agent is able to "adapt fairly well" to a much larger set of environments and is capable of doing this in a reasonable amount of time. In order to address the lack of flexibility and slow convergence to the optimal policy, the new learning agent becomes a hybrid between a learning agent based on instance-based learning and one based on reinforcement learning. To accelerate its convergence to its optimal policy, this new learning agent incorporates the use of a new concept we call propagation of good findings. Furthermore, to make a better use of the learning agent's memory resources,, and therefore increase its flexibility, we make use of another new concept we call moving prototypes.
Estimating the indirect contribution of sports books : sports wagering as a driver of other in-house revenues

Using data from a repeater market hotel in Las Vegas, Nevada, the relationship between sports book and slot machine revenues is examined. Daily sports book write and daily slot handle are compared over a 250 day period. Though many industry leaders theorize that sports book gamblers also wager in slot banks, the results of this research fail to demonstrate a statistically significant relationship between sports book write and slot coin-in. This study advances literature currently available by establishing the lack of such a relationship and disputing the generally accepted assumption that sports books produce a substantial indirect contribution to slot revenues. While the sports book does generate a fairly constant direct profit for the casino, the absolute value of that profit is minimal and the results of the study show there is no indirect profit contribution from sports books to slot machines. Given these results, casino management may want to consider that a sports book is not an optimal use of casino floor space.
Pharmacokinetic and bioequivalence studies of immediate release diclofenac potassium tablets (50mg) in healthy volunteers.

This study was conducted with the aim to determine the pharmacokinetic and bioequivalence of diclofenac potassium 50 mg test (F4) tablet formulation with reference product (Caflam). Present study was single dose, randomized, two phase cross over design, conducted in 12 healthy Pakistani volunteers and planned in accordance with FDA guidelines. In this study a simple, selective, sensitive and reproducible HPLC procedure was developed and validated for the estimation of diclofenac potassium in plasma. The process was validated in the range of 50 - 0.05 µg. mL-1 and used in bioequivalence trial of two products. Multiple blood samples were collected at various time points (0.5, 1, 2, 3, 4, 5, 6, 8, 10, 12 and 14 hr after treating volunteers with test (F4) and marketed reference brand. Plasma separation and deproteination were carried out with acetonitrile; samples (20µL) were injected using the validated HPLC method. Various pharmacokinetic parameters (compartmental and noncompartmental) were estimated using KineticaTM 4.4. 1 (Thermo Electron Corp. USA). Bioequivalence among the products was established by calculating the 90% CI with log and non log transformed data for Cmaxcalc, Tmaxcalc, AUC0-∞, AUCtot and AUClast using two way ANOVA and Schirmann's Two one sided t- test. No significant difference was found between log and non-log data. The 90% confidence interval values using log transformed data for AUC0-∞ (0.997-1.024), AUCtot (1.004-1.031), AUClast (0.997 -1.024), Cmaxcalc (0.994-1.007) and Tmaxcalc (0.996-1.013) for the trial and reference products were found within the FDA acceptable limits of 0.8-1.25. Results were further verified by the Schirmann's one-sided t test. Results showed the bioequivalence of test and reference formulations. Both the products were well tolerated.
A Preliminary Study of Aquatic Macroinvertebrates From Two Springs in the Pontotoc Ridge Nature Preserve, Oklahoma

Biology Department, University of Central Oklahoma, Edmond, Oklahoma 73034The Pontotoc Ridge Nature Preserve is lo-cated in southeastern Pontotoc County,Oklahoma and is currently managed by TheNature Conservancy. It consists of 2000 acresof woodland and prairie vegetation. Severalsmall springs are located on the property andthese serve as headwaters for the Blue Riverand several of its tributaries. Very little isknown regarding the spring invertebratefauna in Oklahoma
THERMAL DECOMPOSITION OF TETRACYCLINE AND CEPHALOSPORINS METAL COMPLEXES

ا ديرولآورديهل ىرارحلا كولسلا سرد تلبوكلا تابآارتمو نيلكيسارتت ىسآولأاو نيلكيسارتتل نيلكيسارتتلل لكينلاو . كنزلا عم تانيروبسولافسلا ضعب تابآارتمل ىرارحلا للحتلا سرد امآ . ترهظأو ةقباسلا تابآرملل ىرارحلا للحتلا نأ ىلع لدي ككفتلا لحارم نم اددع ىرارحلا ىنزولا للحتلا تاينحنم اطيسب سيل . تبسح امآ ةفلتخملا للحتلا تاوطخل ةيكيتنيكلا تباوثلا . نوكت ضرتفأ دقو نيلكيسارتتلا ديرولآورديهل ىرارحلا للحتلا ءانثأ طيسو بآرمآ نيلكيسارتتورديهنأ .
Personal Uncertainty Management by Reactive Approach Motivation

The uncertainty management model (UMM) addresses a basic predicament of the human condition. Personal Uncertainty (PU) has long been identified by classic philosophical, sociological, and psychological theories as a cause of rigid and aggressive phenomena from repression and suicide to prejudice and hate. In this commentary, we review a Reactive Approach Motivation (RAM) view of compensatory conviction and worldview defense that is consistent with the UMM and grounded in the neuropsychology of anxiety. We also report new findings from our lab, cited in the target article, which further illuminate precise triggers of UMM and RAM outcomes. A complementarity of the UMM and our research is that the UMM tends to focus on affective reactions to PU, and our research tends to focus on compensatory worldview reactions to PU. Together, UMM and RAM research support the classic, multidisciplinary observation that PU is aversive and causes consequential outcomes.
The response of intercellular adhesion molecule-1 to exhaustive submaximal exercise and its correlation with physiological and anthropometric measures

Introduction:Intercellular adhesion molecule-1 (ICAM-1) acts as the main factor in the occurrence of atherosclerosis and inflammatory diseases. This study aimed to investigate the response of ICAM-1to exhaustive submaximal exercise and its correlation with maximal oxygen consumption (VO2max), body mass index (BMI), waist-hip ratio (WHR), body fat percentage (BF %) and calories burned during exercise (CB) in healthy men. Materials and methods:Thirteen healthy men (mean ± standard deviation: age 23 ± 3 years, weight 78 ± 4 kg, height 180 ± 4 cm) cooperated in this quasi-experimental study and performed a single bout of exhaustive submaximal exercise on a cycle ergometer. Blood samples were collected from the antecubital vein before and immediately after exercise. Data were analyzed using the paired sample t-test and Pearson's correlation coefficient (α=0.05). Results:Exhaustive submaximal exercisehad no significant effect on serum sICAM-1. Also, there were no significant correlations between ICAM-1 induced by the exhaustive submaximal exercise and VO2max, BMI, WHR, BF % and CB. Conclusions:According to our findings, it cannot be ruled out that exhaustive submaximal exercise results in pathological and inflammatory conditions in healthy men. In Also, anthropometric and physiological parameters do not affect the response of ICAM-1 to exercise in healthy men.
Optimal Data Center Scheduling for Quality of Service Management in Sensor-Cloud

The proposed work concentrates on the networking facets of sensor-cloud infrastructures—one of the first attempts of its kind. In a sensor-cloud, multiple sets of physical sensor nodes that are activated based on an application demand, in turn give rise to multiple distinct virtual sensors (VSs). The VSs are considered to span across multiple geographical regions; thereby, depositing the data (from each of the VS) to the closest cloud data center (DC). Quite obviously, multiple geospatial DCs get involve with an application. However, the principle of sensor-cloud is to store and conglomerate the data from various VSs, before they can be provisioned as Sensors-as-a-Service (Se-aaS). The assortation of data occurs within a single Virtual Machine (VM) (or in some cases multiple VMs) residing inside a particular DC. This work addresses the problem of scheduling a particular DC that congregates data from various VSs, and transmit the same to the end-user application. The work follows the general pairwise choice framework of the Optimal Decision Rule. The scheduling of the DC is performed under several network constraints, such as data migration cost, data delivery cost, and service delay of an application that ensures the preservation of the Quality-of-Service (QoS) and maintenance of the user satisfaction. The work quantifies the effective QoS of Se-aaS and determines an optimal decision rule for electing a particular DC. While arriving at a collective decision, the work incorporates the fallible decision making ability of a DC; thereby, excluding the loss of generality. Experimental results depict that the proposed algorithm for generating the optimal decision rule finds applicability in real-time cloud computing scenarios.
Calling the Ghost of Populism: The AfD's Strategic and Tactical Agendas until the EP Election 2014

Since the formation of the German AfD in spring 2013, political scientists have discussed whether the AfD can be classified as a populist party. Despite the split of the party in summer 2015 leading to this characterisation becoming uncontested, the question remains whether the AfD was populist from its inception. This article demonstrates that distinguishing between the tactical and strategic agendas of the party solves this conundrum. While the AfD seldom applied populist discourse in its official manifestos, its tactical agenda was undoubtedly framed by populism. Ironically, it has been the ideologically moderate economist wing that has applied populist discourse in combination with its critique of the euro.
Bringing Culture Back In: Social Group Polarization and the "Culture Wars" in the U.S.

Ongoing debates about political polarization in the United States have focused on analyzing putative “culture wars” at the elite and mass levels. Despite the terminology, the debate has not addressed cultural groups’ attitudes toward each other, and instead defines polarization in terms of either values and worldviews or parties and voting. These foci have diverted attention from assessing group divisiveness in the U.S. based on social group attachments and evaluations. This paper addresses the question of whether there has been an increase in divisions among social groups over time in the U.S. by analyzing trends in a fundamental psychological affiliation toward groups, people’s sense of favorability toward their in-groups and animosity toward out-groups. Using trend data from 1964-2008, I find little evidence of high or widening polarization on the cleavages of race, class, age, gender, or religion, and generally favorable attitudes toward both in-groups and out-groups.
CITRUS FRUITS BY-PRODUCTS AS SOURCES OF BIOACTIVE COMPOUNDS WITH ANTIOXIDANT POTENTIAL

Peel and pulp from Orlando orange, Kinnow mandarin and Eureka lemon fruits were evaluated for phenolic compounds, ascorbic acid contents and free radical scavenging activities. Pulp from orange, mandarin and lemon contained 123.02, 104.98 and 98.38 mg GAE/100 g total phenolics; 61.38, 38.52 and 57.63 mg/100g ascorbic acid and 69.31, 62.82 and 59.60 % DPPH radical scavenging activities, respectively. Peel from orange, mandarin and lemon contained 178.90, 169.54 and 61.22 mg GAE/100 g total phenolics; 62.45, 54.87 and 25.68 mg/100g ascorbic acid and 67.58, 68.57 and 46.98% DPPH radical scavenging activities, respectively. The data reveals that these citrus by-products are good sources of bioactive compounds and be considered as antioxidant constituents for developing functional foods.
Wideband circularly polarized reconfigurable crossed dipole antenna

A simple design of a wideband circularly polarized (CP) reconflgurable antenna is proposed. The primary radiator consists of two orthogonal straight dipoles while a dual-cavity structure is employed to significantly enhance the overall CP performance of the antenna. The polarization reconfigurability is realized by electronically switching the ON/OFF states of two PIN-diode pairs. Thus, the antenna can radiate CP wave with either rotating senses. The proposed design exhibits a wide simulated impedance bandwidth (BW) of 70.8% and an overlapped axial ratio (AR) BW of 58.5%. In addition, the antenna realized gain is greater than 7.2 dBi and its radiation efficiency is around 90% over the overlapped BW.
A phonetic interpretation of the sound changes affecting dark /l/ in Romance

The paper reviews experimental and descriptive data on /l/ vocalization and elision and related vowel shifts in the Romance languages, and argues that a given sound change may be achieved through different evolutionary paths. While prevailing theories tend to attribute a single articulatory or acoustic cue to changes affecting /l/, we propose instead an explanatory account based on an evaluation of the relative prominence of cues in different contextual and positional conditions on the part of the listener. According to this proposal, several prominent articulatory and/or acoustic characteristics may be responsible for segmental insertions, segmental elisions and sound shifts.
Determination of Surface Coverage and Orientation of Reduced Cytochrome c on a Silica Surface with Polarized ATR Spectroscopy

Linearly polarized attenuated total internal reflection (ATR) spectroscopy is used to study the adsorption properties of reduced cytochrome c to a silica surface. The adsorption equilibrium constant, surface coverage, protein orientation, effect of NaCl, and pH dependence are determined for the adsorption of reduced cytochrome c onto a silica surface. Surface coverage results (at pH 7.2) show that reduced cytochrome c packs onto the silica surface at <80% of a closely packed monolayer. The protein orientation distribution as measured by an order parameter is shown to be dependent on the surface coverage and solution pH. All of the results for the surface adsorption of reduced cytochrome c on silica are indicative of an electrostatically driven interaction. The results for reduced cytochrome c are compared to surface adsorption results for oxidized cytochrome c on silica. These results indicate that there is no significant difference in the adsorption behavior correlating to the oxidation state of this hem.
Reconstruction of vascular niche of neural stem cells using perfusable microfluidic device

In brain, vascular niche is well known to function for regulation of proliferation and cell fate decision of neural stem cells (NSCs). The NSC niche is composed of vascular endothelial cells (VECs), and shear stress is known as a key factor on activity of the VECs. To reconstruct the NSC niche, perfusable coculture system is needed. Here we developed perfusable microfluidic device for coculture of NSCs and VECs under shear stress mimicking physiological flow. We found that NSCs and VECs were activated under the shear stress, and highly expressed NSC-associated genes and shear stress responsive genes, respectively. The finding indicates that the culture system using the microfluidic device can reproduce NSC niche for research on development, homeostasis and regeneration of central nervous system (CNS).
Robust tracking designs for both holonomic and nonholonomic constrained mechanical systems: adaptive fuzzy approach

Adaptive fuzzy-based tracking control designs are proposed in the paper for both holonomic mechanical systems as well as a large class of nonholonomic mechanical systems with plant uncertainties and external disturbances. A unified and systematic procedure is employed to derive the controllers for both holonomic and nonholonomic mechanical control systems, respectively. First, a fuzzy logic system is introduced to learn the behavior of unknown (or uncertain) mechanical dynamics by using an adaptive algorithm. Next, the effect of approximation error on the tracking error must be efficiently eliminated by employing an additional robustifying algorithm. Consequently, hybrid adaptive-robust controllers can be constructed such that the resulting closed-loop mechanical systems guarantee a satisfactorily transient and asymptotic performance. Furthermore, a partitioned procedure with respect to the above developed adaptive fuzzy logic approximators is introduced such that the number of fuzzy IF-THEN rules is significantly reduced and the developed control schemes can be easily implemented from the viewpoint of practical applications. Finally, simulation examples are presented to illustrate the tracking performance of a two-link constrained robot manipulator and a vertical wheel rolling on a plane surface by the proposed adaptive fuzzy-based control algorithms.