Miracle-dz/UniFAR-FTUs huggingface dataset:
comparisons between ticagrelor and clopidogrel following percutaneous coronary intervention in patients with acute coronary syndrome: a comprehensive meta-analysis

Background: The efficacy and safety of ticagrelor following percutaneous coronary intervention for patients with acute coronary syndrome remains unclear. This study sought to evaluate clinical outcomes of ticagrelor as part of dual-antiplatelet treatment for these patients. Methods: PubMed, MEDLINE, Embase, and other Internet sources were searched for eligible citations. The primary end point was major adverse cardiovascular and cerebrovascular events, consisting of cardiovascular death, myocardial infarction, and stroke. The secondary end point was the occurrence of definite/probable stent thrombosis (ST). The risk of bleeding was chosen to be the safety end point. Results: Eleven clinical trials – six randomized trials and five observational trials – were finally analyzed. A tendency toward reduction in the risk of major adverse cardiovascular and cerebrovascular events was observed only with respect to ticagrelor (OR 0.83, 95% CI 0.66–1.03; P = 0.091), which might have resulted from the lower risk of cardiovascular death (OR 0.78, 95% CI 0.68–0.89; P , 0.001). The overall incidence of ST differed significantly between the ticagrelor group and the clopidogrel group (OR 0.74, 95% CI 0.59–0.93; P = 0.009), but the risk of bleeding, regardless of major or minor bleeding, increased significantly. Conclusion: As part of dual-antiplatelet treatment following percutaneous coronary intervention, ticagrelor significantly reduced the risk of cardiovascular death and ST in acute coronary syndrome patients, but at the cost of bleeding. More powerful relevant randomized trials are still warranted to guide clinical decision-making.
Software Security: Building Security In

Summary form only given. Software security has come a long way in the last few years, but we've really only just begun. I will present a detailed approach to getting past theory and putting software security into practice. The three pillars of software security are applied risk management, software security best practices (which I call touchpoints), and knowledge. By describing a manageably small set of touchpoints based around the software artifacts that you already produce, I avoid religious warfare over process and get on with the business of software security. That means you can adopt the touchpoints without radically changing the way you work. The touchpoints I will describe include: code review using static analysis tools; architectural risk analysis; penetration testing; security testing; abuse case development; and security requirements. Like the yin and the yang, software security requires a careful balance-attack and defense, exploiting and designing, breaking and building-bound into a coherent package. Create your own Security Development Lifecycle by enhancing your existing software development lifecycle with the touchpoints
A Thematic Analysis Investigating the Impact of Positive Behavioral Support Training on the Lives of Service Providers: “It Makes You Think Differently”

Positive behavioral support (PBS) employs applied behavioral analysis to enhance the quality of life of people who behave in challenging ways. PBS builds on the straightforward and intuitively appealing notion that if people know how to control their environments, they will have less need to behave in challenging ways. Accordingly, PBS focuses on the perspective of those who have behavioral issues, and assesses success via reduction in incidences of challenging behaviors. The qualitative research presented in this report approaches PBS from a different viewpoint and, using thematic analysis, considers the impact of PBS training on the lived experience of staff who deliver services. Thirteen support staff who work for a company supplying social care and supported living services for people with learning disabilities and complex needs in the northwest of England took part. Analysis of interviews identified five major themes. These were: (1) training: enjoyable and useful; (2) widening of perspective: different ways of thinking; (3) increased competence: better outcomes; (4) spill over into private lives: increased tolerance in relationships; and (5) reflecting on practice and moving to a holistic view: “I am aware that people…are not just being naughty. ” These themes evidenced personal growth on the part of service providers receiving training. Explicitly, they demonstrated that greater awareness of PBS equipped recipients with an appropriate set of values, and the technical knowledge required to realize them.
The Open Access Institutional Repository at Robert Gordon University Citation Details Citation for the Version of the Work Held in 'openair@rgu': Testing an Integrated Behavioural and Biomedical Model of Disability in N-of-1 Studies with Chronic Pain School of Psychology And

This version may not include final proof corrections and does not include published layout or pagination. integrated behavioural and biomedical model of disability in N-of-1 studies with chronic pain. Available from OpenAIR@RGU. integrated behavioural and biomedical model of disability in N-of-1 studies with chronic pain. are protected by copyright and intellectual property law. If you believe that any material held in 'OpenAIR@RGU' infringes copyright, please contact openair-help@rgu.ac. uk with details. The item will be removed from the repository while the claim is investigated. Abstract Background. Previous research has supported an integrated biomedical and behavioural
Coupled Congestion Control for Multipath Transport Protocols

Often endpoints are connected by multiple paths, but communications are usually restricted to a single path per connection. Resource usage within the network would be more efficient were it possible for these multiple paths to be used concurrently. Multipath TCP is a proposal to achieve multipath transport in TCP. New congestion control algorithms are needed for multipath transport protocols such as Multipath TCP, as single path algorithms have a series of issues in the multipath context. One of the prominent problems is that running existing algorithms such as TCP New Reno independently on each path would give the multipath flow more than its fair share at a bottleneck link traversed by more than one of its subflows. Further, it is desirable that a source with multiple paths available will transfer more traffic using the least congested of the paths, hence achieving resource pooling. This would increase the overall utilization of the network and also its robustness to failure. This document presents a congestion control algorithm which couples the congestion control algorithms running on different subflows by linking their increase functions, and dynamically controls the overall aggresiveness of the multipath flow. The result is a practical algorithm that is fair to TCP at bottlenecks while moving traffic away from congested links.
Internet Engineering Task Force (ietf) Simple Reed-solomon Forward Error Correction (fec) Scheme for Fecframe

This document describes a fully-specified simple Forward Error Correction (FEC) scheme for Reed-Solomon codes over the finite field (also known as the Galois Field) GF(2^^m), with 2 <= m <= 16, that can be used to protect arbitrary media streams along the lines defined by FECFRAME. The Reed-Solomon codes considered have attractive properties, since they offer optimal protection against packet erasures and the source symbols are part of the encoding symbols, which can greatly simplify decoding. However, the price to pay is a limit on the maximum source block size, on the maximum number of encoding symbols, and a computational complexity higher than that of the Low-Density Parity Check (LDPC) codes, for instance. Information about the current status of this document, any errata, and how to provide feedback on it may be obtained at in effect on the date of publication of this document. Please review these documents carefully, as they describe your rights and restrictions with respect to this document. Code Components extracted from this document must include Simplified BSD License text as described in Section 4.e of the Trust Legal Provisions and are provided without warranty as described in the Simplified BSD License.
Joint Non-negative Matrix Factorization for Learning Ideological Leaning on Twi er

People are shifting from traditional news sources to online news at an incredibly fast rate. However, the technology behind online news consumption promotes content that con rms the users’ existing point of view. This phenomenon has led to polarization of opinions and intolerance towards opposing views. Thus, a key problem is to model information lter bubbles on social media and design methods to eliminate them. In this paper, we use a machine-learning approach to learn a liberal-conservative ideology space on Twitter, and show how we can use the learned latent space to tackle the lter bubble problem. We model the problem of learning the liberal-conservative ideology space of social media users and media sources as a constrained non-negative matrix-factorization problem. Our model incorporates the social-network structure and content-consumption information in a joint factorization problem with shared latent factors. We validate our model and solution on a real-world Twitter dataset consisting of controversial topics, and show that we are able to separate users by ideology with over 90% purity. When applied to media sources, our approach estimates ideology scores that are highly correlated (Pearson correlation 0.9) with ground-truth ideology scores. Finally, we demonstrate the utility of our model in real-world scenarios, by illustrating how the learned ideology latent space can be used to develop exploratory and interactive interfaces that can help users in di using their information lter bubble.
Particle acceleration in superbubbles: MHD simulations and 𝜸 -ray signatures

An increasing number of star-forming regions and young star clusters are detected in 𝛾 -rays, which hints at ongoing particle acceleration. These regions harbour young massive stars, whose powerful winds collectively blow superbubbles (SBs) containing large-scale shocks and tenuous, hot, turbulent plasma. Investigating the physics of SBs is necessary to clarify their role as galactic cosmic ray (CR) sources and their ability to reach energies > 1 PeV. In [1], we presented a one-zone emission model for the ring-like H.E. S.S. source surrounding Westerlund 1, a prototypical example for a young massive cluster. The spectrum and the morphology of the source are consistent with a leptonic inverse Compton model, in which the acceleration takes place at the cluster wind termination shock. The ring-like morphology, overall size of the emission region, and energetics disfavour both hadronic models and alternative acceleration sites. Our results showcase the impact of certain environmental parameters on key characteristics of the system. For example, the strength and topology of the magnetic ﬁeld are critical for the maximum energy, as they aﬀect the acceleration time and particle transport. We brieﬂy summarise the key ﬁndings of the Westerlund 1 phenomenological analysis, followed by a report on ongoing work on MHD simulations of star cluster wind.
Assessment of the accuracy of different systems for measuring football velocity and spin rate in the field

The aim of this study was to measure the level of agreement of four portable football velocity and spin rate measurement systems (Jugs speed radar gun, 2-D high-speed video, TrackMan and adidas miCoach football) against a Vicon motion analysis system. One skilled male university football player performed 70 shots covering a wide range of ball velocities (12–30 m s−1) and spin rates (94–743 r/min). A Bland–Altman analysis was used to assess the level of agreement. For ball velocity, the 2-D high-speed video had the smallest systematic error, followed by the radar gun, TrackMan and miCoach football at 0.2, 0.4, 0.5 and 4.8 m s−1, respectively. A similar ranking was also observed for the random errors (95% confidence intervals: ±0.4, ±1.5, ±1.9 and ±6.0 m s−1). The first three systems all tracked ball velocity in >90% of shots, while the miCoach football tracked slightly fewer shots (79%). For spin rate, the miCoach football had a much smaller systematic error (4 vs 38 r/min) and random error (95% confidence intervals: ±24 vs ±355 r/min) compared to TrackMan. The miCoach also successfully tracked spin rate in more shots than the TrackMan (79% vs 44%). These results indicate that 2-D high-speed video would be the preferred option for the field assessment of ball velocity; however, radar gun and TrackMan may also be appropriate. A minimum of 10 frames of 2-D high-speed video, captured close to the ball starting position, was demonstrated to be sufficient in providing a reliable measure of ball velocity. The miCoach ball is the preferred option for field assessment of ball spin rate.
neoadjuvant chemotherapy with radical surgery vs radical surgery alone for cervical cancer: a systematic review and meta-analysis

Aim: This systematic review was designed to evaluate the efficacy of neoadjuvant chemotherapy with radical surgery vs radical surgery alone for cervical cancer. Methods: A computerized search was done for trials from PubMed, EMBASE, CENTRAL, and Cochrane Database of Systematic Reviews. The trials included neoadjuvant chemotherapy plus radical surgery vs radical surgery alone. We measured overall survival (OS), disease-free survival (DFS), progression-free survival (PFS), local and distant recurrence, lymph node metastasis, and parametrial infiltration per patient. Results: In all, 13 studies involving 2,158 subjects were included. In regard to OS, DFS, PFS, local and distant recurrence, and parametrial infiltration, neoadjuvant chemotherapy plus radical surgery was similar to radical surgery alone. Among them, subgroup analysis of eight studies involving 1,544 patients with locally advanced cervical cancer (FIGO stage IB2–IIB) showed that neoadjuvant chemotherapy (NACT) plus radical surgery significantly improved OS, and decreased local and distant recurrence rates, lymph node metastasis rate, and the level of parametrial infiltration compared to radical surgery alone. Conclusion: The present study demonstrates that preoperative NACT is now an accepted effective procedure in selected patients with locally advanced cervical cancer (FIGO stage IB2–IIB). However, the relationship between NACT and longer DFS and PFS cannot be demonstrated by this meta-analysis. Thus, the decision to use or not to use NACT before radical surgery depends on the surgeon’s experience and clinical judgment. Nevertheless, further research in this field is urgently needed to confirm it.
Genome sequence of the corn leaf aphid (Rhopalosiphum maidis Fitch)

Background The corn leaf aphid (Rhopalosiphum maidis Fitch) is the most economically damaging aphid pest on maize (Zea mays), one of the world’s most important grain crops. In addition to causing direct damage due to the removal of photoassimilates, R. maidis transmits several destructive maize viruses, including Maize yellow dwarf virus, Barley yellow dwarf virus, Sugarcane mosaic virus, and Cucumber mosaic virus. Findings A 326-Mb genome assembly of BTI-1, a parthenogenetically reproducing R. maidis clone, was generated with a combination of PacBio (208-fold coverage) and Illumina sequencing (80-fold coverage), which contains a total of 689 contigs with an N50 size of 9.0 Mb. The contigs were further clustered into four scaffolds using the Phase Genomics Hi-C interaction maps, consistent with the commonly observed 2n = 8 karyotype of R. maidis. Most of the assembled contigs (473 spanning 321 Mb) were successfully orientated in the four scaffolds. The R. maidis genome assembly captured the full length of 95.8% of the core eukaryotic genes, suggesting that it is highly complete. Repetitive sequences accounted for 21.2% of the assembly, and a total of 17,647 protein-coding genes were predicted in the R. maidis genome with integrated evidence from ab initio and homology-based gene predictions and transcriptome sequences generated with both PacBio and Illumina. An analysis of likely horizontally transferred genes identified two from bacteria, seven from fungi, two from protozoa, and nine from algae. Conclusions A high-quality R. maidis genome was assembled at the chromosome level. This genome sequence will enable further research related to ecological interactions, virus transmission, pesticide resistance, and other aspects of R. maidis biology. It also serves as a valuable resource for comparative investigation of other aphid species.
OTT_A_229577 185..197

1Huadu District People’s Hospital of Guangzhou, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China; 2State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong Province, People’s Republic of China; 3Department of Health Service Management, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, People’s Republic of China
Middle Grade Students’ Evoked Concept Images of Number Line Models and Their Calculation Strategies with Integers Using These Models

Number line models provide a visual aid for students to examine the relationship of integers with each other and facilitate learning of integers and integer operations. Such models are typically used when students are asked real-life problems. This study employs a qualitative case study design to perform an in-depth analysis of how middle grade students use number line models and which models they instinctively prefer for different real-life contexts. To understand students‟ way of thinking, a questionnaire including real-life context problems about integers was used. Additionally, interview data was used to get a deep insight into students‟ written responses. The results indicated that middle grade students have three evoked concept images of number line models namely, horizontal, vertical, and the Cartesian plane combining the two. The horizontal number line model was found to dominate over the other two models even in contexts that are typically associated with a vertical one. The study also found that more than half of the students that took part in the study could not properly use any number line model. Finally, the study added to the evidence that there was a symbiotic relationship between arithmetic calculation and using number line in that errors made during one are often corrected with the other.
Hepatic Arterial Infusion Oxaliplatin Plus Oral S-1 Chemotherapy in Gastric Cancer with Unresectable Liver Metastases: A Case Series and Literature Review

Objective: The use of hepatic artery infusion (HAI) as a regional therapy against liver metastasis has rarely been reported in gastric cancer. This study aimed to evaluate the ef ﬁ cacy and safety of HAI oxaliplatin plus oral S-1 chemotherapy in ﬁ rst-line palliative therapy for gastric cancer with multiple liver metastases (GCLM). Methods: We reviewed the records of ﬁ ve patients with GCLM who received HAI oxaliplatin (70 – 80 mg/m 2 2 hrs d1,15) administered via a port-catheter system and S-1 with oral (35 – 40 mg/m 2 twice daily for d1-14, 28 days for one cycle). Follow-up examination and ef ﬁ cacy evaluation were executed periodically. Results: Until the 4th cycle response evaluation, the local effective rate and control rate were 40% and 80%, respectively; only one patient developed progression. HAI chemotherapy had a better local control against liver metastases (median progression-free survival: hepatic, 8.8 months vs. extrahepatic, 6.2 months), accompanied by less systemic toxicity, decreased tumour markers and symptomatic relief. Conclusion: HAI oxaliplatin plus oral S-1 chemotherapy can be considered as a new choice of ﬁ rst-line treatment for GCLM, which is also a good approach for controlling extrahepatic lesions with less adverse events.
The association between inflammation, the microbiome and urethane-induced pulmonary adenocarcinoma

Lung cancer is amongst the most common types of cancer throughout the world. The overall 5-year survival rate is ~17%. A number of studies have demonstrated that the microbiome existing within the host may affect the level of inflammation, and consequently contribute to the carcinogenesis of certain types of cancer. To investigate the role of inflammation and the microbiome in the carcinogenesis of lung cancer, an intervention study involving mice, including a control group (C; n=5), a urethane-induced pulmonary adenocarcinoma group (U; n=5) and a prebiotics intervention group (P; n=5) was carried out. This pulmonary adenocarcinoma model was reviewed, and incidences of the disease were identified using histopathology. The levels of the inflammatory cytokines nuclear factor κB (NF-κB), tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β) and IL-6 in the sera samples were measured using an ELISA technique. In addition, high-throughput sequencing of the 16S ribosomal RNA gene segment was used to analyze the species present in the microbiome of the lower airways and intestinal tracts of mice. The results demonstrated that groups P and U exhibited altered histopathology and the development of lung adenocarcinoma tumors, but no differences were observed between the groups. The level of inflammation, determined by measuring the levels of NF-κB, TNF-α, IL-1β and IL-6 inflammatory cytokines, was significantly lower in group P compared with group U (P<0.05), and was significantly higher in group P compared with group C (P<0.05). Overall, the microbiomes of the lower respiratory and intestinal tracts did not change markedly among the 3 groups, in terms of the size of colonies and Shannon diversity indices. However, at a family and operational taxonomic unit (OTU) level, certain microbiota were altered. For example, the abundance of the Clostridiales and Lachnospiraceae families was lower in the lung and intestinal tracts subsequent to urethane-induced treatment compared with in the control group (P<0.05), and the level of abundance of the Clostridiales family increased to similar levels within the control group (P<0.05), when prebiotics were administered. The levels of abundance of the S24-7, Bacteroidales and Firmicutes families were higher in the intestinal tract compared with the control group (P<0.05), and following treatment with prebiotics, the levels of abundance of these families decreased to similar levels observed in the control group (P<0.05). In conclusion, inflammation and the microbiome serve important roles in the carcinogenesis of lung cancer. Additionally, prebiotics may increase the efficacy of lung cancer treatment by modulating levels of inflammation and the composition of the microbiome. The associations between inflammation, the microbiome and lung cancer require attention.
Backpropagation algorithm which varies the number of hidden units

Summary form only given, as follows. A backpropagation algorithm is presented that varies the number of hidden units. The algorithm is expected to escape local minima and makes it no longer necessary to decide on the number of hidden units. Exclusive-OR training and 8*8 dot alphanumeric font training using this algorithm are explained. In exclusive-OR training, the probability of being trapped in local minima is reduced. In alphanumeric font training, the network converted two to three times faster than the conventional backpropagation algorithm. >