Miracle-dz/UniFAR-FTUs huggingface dataset:
Tourism research in the new millennium: A bibliometric review of literature in Tourism and Hospitality Research

This article presents a bibliometric review analyzing 15 years of research published between 2000 and 2014 in the journal Tourism and Hospitality Research. Raw citations metrics were gathered using “Publish or Perish,” a data-miner software from Harzing, using Google Scholar as a base. The analysis focuses on six key metrics of the journal’s publications: (a) the nature of authorship, (b) the most influential articles, (c) the most influential authors, (d) the most prolific authors, (e) the themes covered, and (f) the manuscript characteristics of the articles published during the period. Notes for contributors, book reviews, conference reports/proceedings, practice papers, and editorials were excluded from the scope of this research, and 292 research articles appearing in the journal during this time were included in the investigation. Data were analyzed using SPSS and Excel. The article provides an overview of the evolution of the journal and presents some key trends in ongoing research within the industry. The study finds a clear trend toward coauthorship with a substantial increase in triple-authored articles. The majority of the articles have gone from being single authored in 2000–2004 to being dual authored in 2010–2014. Articles on marketing and consumer behavior, HR management, and environmental aspects have experienced a steady increase while strategic implications, hospitality and tourism operations, impact assessment and mitigation, and education have received a decreased attention. There has been a significant drop in theory development articles, in favor of quantitative research designs, in particular survey studies. Qualitative research designs rest relatively constant; however, case studies and interviews have lost ground to content analysis manuscripts. Contributions further include insights that can aid editors in determining future directions of the journal, guidance for potential authors in their quest to get published, and identification of new opportunities in research areas for the journal and researchers alike.
Design and milling manufacture of polyurethane custom contoured cushions for wheelchair users.

BACKGROUND The design of custom contoured cushions manufactured in flexible polyurethane foams is an option to improve positioning and comfort for people with disabilities that spend most of the day seated in the same position. These surfaces increase the contact area between the seat and the user. This fact contributes to minimise the local pressures that can generate problems like decubitus ulcers. The present research aims at establishing development routes for custom cushion production to wheelchair users. This study also contributes to the investigation of Computer Numerical Control (CNC) machining of flexible polyurethane foams. METHOD The proposed route to obtain the customised seat began with acquiring the user's contour in adequate posture through plaster cast. To collect the surface geometry, the cast was three-dimensionally scanned and manipulated in CAD/CAM software. CNC milling parameters such as tools, spindle speeds and feed rates to machine flexible polyurethane foams were tested. These parameters were analysed regarding the surface quality. The best parameters were then tested in a customised seat. The possible dimensional changes generated during foam cutting were analysed through 3D scanning. Also, the customised seat pressure and temperature distribution was tested. RESULTS The best parameters found for foams with a density of 50kg/cm(3) were high spindle speeds (24000 rpm) and feed rates between 2400-4000mm/min. Those parameters did not generate significant deformities in the machined cushions. The custom contoured cushion satisfactorily increased the contact area between wheelchair and user, as it distributed pressure and heat evenly. CONCLUSION Through this study it was possible to define routes for the development and manufacturing of customised seats using direct CNC milling in flexible polyurethane foams. It also showed that custom contoured cushions efficiently distribute pressure and temperature, which is believed to minimise tissue lesions such as pressure ulcers.
Occlusion in Implant Dentistry-Issues and Considerations

The goal of any prosthetic procedure must include the establishment of a functional occlusion. It is known that natural teeth have periodontal ligament receptors that protect the teeth from excessive occlusal forces, which can cause trauma to supporting tissues and bone. Although many factors are involved in the neuro-muscular reex actions in natural teeth,there are no specic defense mechanisms against occlusal forces in implant-supported prosthesis. Complications (prosthetic or bony support) reported in follow-up studies underline occlusion as one of the determining factors for success or failure of implants.
The UK International Investment Position

This article looks at how the United Kingdom can, surprisingly, generate net investment income from net debt. The article explores the possible linkages between the improvement in net investment income and the stability of the sterling effective exchange rate index in the face of persistent trade deficits. It identifies some risks to net investment income from shifts in relative yields and a rise in global interest rates. With the rapid increase in cross-border asset trade, particularly in financial centres such as the United Kingdom, fluctuations in asset prices have become more powerful influences on our net debt position than in the past. Capital gains can stabilise a net external debt position even in the face of ongoing trade deficits, potentially reducing the extent of any adjustment to the exchange rate.
Trajectory tracking problem based-on output feedback control for linear systems with actuator jumping fault and its application in orbit maneuvering

The trajectory tracking control problems for linear systems with actuator jumping fault is studied in this paper. The main contribution is that it is obtained the complete parametric expression of the controller for the systems. The existence condition of the controller is deduced based on the Lyapunov stability theory. A linear matrix inequality method is used for the output feedback control law which is synchronously switched with the mode of the fault that make the systems stochastically stable. Based on the theory of the generalized Sylvester equations, a parametric method is established for the output model reference tracking problem. The controller is simulated under the spacecrafts rendezvous task which is about the two spacecrafts running on a circular orbit. The simulation results show the effectiveness of the proposed approaches.
DROUGHT STRESS AND INBREEDING DEPRESSION IN LYCHNIS FLOS‐CUCULI (CARYOPHYLLACEAE)

Interactions between drought stress and inbreeding depression were studied in Lychnis flos‐cuculi. Four inbreeding levels (F = 0, 0.25, 0.50 and 0.75), and three watering treatments were used. Performance was scored for germination rate and proportion, survival, plant size, proportion of plants flowering, flowering date, stem height, number of flowers, flower size, anther weight, fruiting proportion and number of capsules. Multiplicative fitness values were estimated from these traits. Inbreeding affected most of the traits studied, and a severe inbreeding depression was found for the combined fitness estimates. The higher inbreeding depression found here relative to the same family groups in a former experiment may reflect greater dominance and suppression in the present experiment at higher density.
Comparison of SF-36 and WHOQOL-100 in patients with stroke.

BACKGROUND AND AIMS Two widely used evaluation tools for the quality of life are the 36-item Short-Form Health Survey (SF-36) and World Health Organization Quality of Life Assessment (100-item version) (WHOQOL-100), however, these tools have not been compared for patients with stroke to date. The specific objectives of this study were: 1) to study the effect of stroke on quality of life (QOL) as measured by the SF-36 and by the WHOQOL-100, and 2) to compare these two instruments. SETTINGS AND DESIGN Seventy patients who were admitted to the neurology clinic six months after stroke were included in this study. PATIENTS AND METHODS As a data-collecting device, the SF-36 and WHOQOL-100 scales were used. An additional questionnaire was administered to obtain demographic data. STATISTICAL ANALYSIS Pearson correlation analysis was performed and Blant-Altman Plots were used. Psychometric analysis was performed. RESULTS In stroke, the most flustered domains of quality of life were vitality and general health perception fields in the SF-36 and in the WHOQL-100, independence level field, overall QOL and general health perceptions. While there was a fair degree of relationship (r= 0.25-0.50) between general health perceptions, physical, social and mental fields that were similar fields of scales, a fair and moderate to good relationship was found between different fields. Limits of agreement in similar domains of the two instruments were very large. In all four demonstrated Bland-Altman plots, there was agreement of the scales in the measurements of similar fields of quality of life. CONCLUSION This study demonstrated that both the SF-36 and WHOQOL-100 quality of life scales are useful in the practical evaluation of patients with stroke.
AMINOETHOXYVINYLGLYCINE AND FOLIAR ZINC TREATMENTS PLAY A KEY ROLE IN PRE-HARVEST DROPS AND FRUIT QUALITY ATTRIBUTES OF ‘WILLIAM’S PRIDE’ APPLE

Effects of pre-harvest aminoethoxyvinylglycine (AVG, 250 mg L–1) and zinc (0.3% ZnSO4) treatments on pre-harvest fruit drops, internal ethylene concentration (IEC), flesh firmness, color characteristics (L*, chroma and hue angle), soluble solids content (SSC), acidity, total phenolics, antioxidant activity, flesh and leaf micronutrients and macronutrients of ‘William’s Pride’ apples, were investigated in this study. AVG was sprayed 4 weeks before the anticipated harvest date and Zn was sprayed when the fruits reached the size of a walnut. As compared to the control, both the single AVG and zinc treatments significantly reduced the pre-harvest drops. However, combined AVG + Zinc treatments were found to be more effective in reducing the pre-harvest drops. At the last measurement date (15th of August), 60% fruit drop was measured in control, but 22% in AVG + Zinc treatment. AVG and AVG + Zinc treatments reduced ethylene synthesis. On the other hand, single zinc treatments stimulated ethylene synthesis. AVG treatments retarded red skin color development, but zinc treatments again stimulated red color development. As compared to the control and single zinc treatments, AVG-treated fruits had greater firmness and acidity values, but lower SSC values. While AVG treatments increased the total phenolics and antioxidant activity, zinc treatments decreased these attributes. As compared to the control, zinc treatments significantly increased flesh Cu, N, P and K contents and leaf Mn, N and P contents. Based on present findings, it was concluded that AVG could be used as an efficient tool to reduce the pre-harvest drops in apples.
Structural characterization of the heme‐based oxygen sensor, AfGcHK, its interactions with the cognate response regulator, and their combined mechanism of action in a bacterial two‐component signaling system

The oxygen sensor histidine kinase AfGcHK from the bacterium Anaeromyxobacter sp. Fw 109‐5 forms a two‐component signal transduction system together with its cognate response regulator (RR). The binding of oxygen to the heme iron of its N‐terminal sensor domain causes the C‐terminal kinase domain of AfGcHK to autophosphorylate at His183 and then transfer this phosphate to Asp52 or Asp169 of the RR protein. Analytical ultracentrifugation revealed that AfGcHK and the RR protein form a complex with 2:1 stoichiometry. Hydrogen‐deuterium exchange coupled to mass spectrometry (HDX‐MS) suggested that the most flexible part of the whole AfGcHK protein is a loop that connects the two domains and that the heme distal side of AfGcHK, which is responsible for oxygen binding, is the only flexible part of the sensor domain. HDX‐MS studies on the AfGcHK:RR complex also showed that the N‐side of the H9 helix in the dimerization domain of the AfGcHK kinase domain interacts with the helix H1 and the β‐strand B2 area of the RR protein's Rec1 domain, and that the C‐side of the H8 helix region in the dimerization domain of the AfGcHK protein interacts mostly with the helix H5 and β‐strand B6 area of the Rec1 domain. The Rec1 domain containing the phosphorylable Asp52 of the RR protein probably has a significantly higher affinity for AfGcHK than the Rec2 domain. We speculate that phosphorylation at Asp52 changes the overall structure of RR such that the Rec2 area containing the second phosphorylation site (Asp169) can also interact with AfGcHK. Proteins 2016; 84:1375–1389. © 2016 Wiley Periodicals, Inc.
Crystal Structure of the Extended-Spectrum β-Lactamase PER-2 and Insights into the Role of Specific Residues in the Interaction with β-Lactams and β-Lactamase Inhibitors

ABSTRACT PER-2 belongs to a small (7 members to date) group of extended-spectrum β-lactamases. It has 88% amino acid identity with PER-1 and both display high catalytic efficiencies toward most β-lactams. In this study, we determined the X-ray structure of PER-2 at 2.20 Å and evaluated the possible role of several residues in the structure and activity toward β-lactams and mechanism-based inhibitors. PER-2 is defined by the presence of a singular trans bond between residues 166 to 167, which generates an inverted Ω loop, an expanded fold of this domain that results in a wide active site cavity that allows for efficient hydrolysis of antibiotics like the oxyimino-cephalosporins, and a series of exclusive interactions between residues not frequently involved in the stabilization of the active site in other class A β-lactamases. PER β-lactamases might be included within a cluster of evolutionarily related enzymes harboring the conserved residues Asp136 and Asn179. Other signature residues that define these enzymes seem to be Gln69, Arg220, Thr237, and probably Arg/Lys240A (“A” indicates an insertion according to Ambler's scheme for residue numbering in PER β-lactamases), with structurally important roles in the stabilization of the active site and proper orientation of catalytic water molecules, among others. We propose, supported by simulated models of PER-2 in combination with different β-lactams, the presence of a hydrogen-bond network connecting Ser70-Gln69-water-Thr237-Arg220 that might be important for the proper activity and inhibition of the enzyme. Therefore, we expect that mutations occurring in these positions will have impacts on the overall hydrolytic behavior.
LEVETIRACETAM: A NEW THERAPEUTIC OPTION FOR REFRACTORY EPILEPSY

Levetiracetam (LEV) is the most recently licensed antiepileptic drug (AED) for adjunctive therapy of partial seizures. Its mechanism of action is uncertain but it exhibits a unique profile of anticonvulsant activity in models of chronic epilepsy. Three randomised, double‐blind, placebo‐controlled trials enrolling 904 patients with refractory partial epilepsy have demonstrated the efficacy of LEV as adjunctive therapy, with a responder rate (≥50% reduction in seizure frequency) of 28–41%. Long‐term efficacy studies suggest retention rates of 60% after one year, with 13% of patients seizure‐free for six months of the study and 8% seizure‐free for one year. Adverse effects of LEV, including somnolence, lethargy and dizziness, were generally mild and the frequency of incidents was not significantly different between the active treatment and placebo groups in clinical trials. LEV has no clinically significant pharmacokinetic interactions (PKI) with other AEDs, or with commonly prescribed medications. Preliminary data suggest that LEV has efficacy in primary generalised epilepsy and further randomised trials are under way. The combination of potent antiepileptic properties with a relatively mild adverse effect profile makes LEV an attractive adjunctive therapy for partial seizures.
Pathophysiology of Transfusional Iron Overload: Contrasting Patterns in Thalassemia Major and Sickle Cell Disease

The pathophysiological consequences of transfusional iron overload largely reflect the pattern of excess iron distribution and include cardiomyopathy, endocrinopathy, cirrhosis, and hepatocellular carcinoma. Since the introduction of desferrioxamine (DFO) in the late 1970s, these complications have fallen substantially but approximately half of the chelated adult patients with thalassemia major (TM) still show evidence of increased myocardial iron loading by MRI. An understanding of the factors that determine the propensity to extrahepatic iron distribution may be a key to minimizing the pathophysiological consequences of transfusional iron overload. Transfused patients with sickle cell disease (SCD) appear less likely to develop these extrahepatic complications, possibly because plasma nontransferrin-bound iron (NTBI) levels are typically lower than in TM patients at matched levels of iron loading. Other mechanisms that may reduce the extrahepatic iron distribution in SCD include raised plasma hepcidin due to chronic inflammation, lower growth differentiation factor 15 (GDF15) levels because of less ineffective erythropoiesis (IE), and induction of heme oxygenase (HO1) by intravascular hemolysis. Further understanding of these mechanisms may help in designing strategies to decrease extrahepatic iron distribution in TM.
Kinetics of the block by intracellular Mg2+ of the NMDA‐activated channel in cultured rat neurons.

1. Single‐channel currents activated by the glutamate agonist N‐methyl‐D‐aspartate (NMDA) were recorded from outside‐out patches of cultured rat cortical neurons in the presence of intracellular Mg2+ (Mgi2+). The rate constants of the block by Mgi2+ were measured using amplitude distribution analysis. 2. At a membrane potential of 0 mV, the blocking rate constant (k+) of Mgi2+ was estimated to be 2.1 x 10(7) M‐1 S‐1 and the unblocking rate constant (k‐) 1.7 x 15(5)s‐1. The very fast rate constants of the block by Mgi2+ explain why channel flicker was not fully resolvable during block of the NMDA‐activated single‐channel current by Mgi2+. 3. The blocking rate constant of Mgi2+ increased with increasing concentrations of Mgi2+. The unblocking rate constant was Mgi2+ concentration independent. 4. The blocking rate constant increased e‐fold per 64 mV depolarization, whereas the unblocking rate constant decreased e‐fold per 133 mV depolarization. The dissociation constant (KD) calculated from the blocking rates (k‐/k+) decreased e‐fold per 43 mV depolarization, and had a value at 0 mV of 7.8 mM. These values are consistent with previous estimates obtained from the voltage‐dependent inhibition of the single‐channel current amplitude. Both results predict, based on the Woodhull model, that Mgi2+ traverses about one‐third of the membrane field to reach its blocking site. 5. The unblocking rate constant of Mgi2+ is one to two orders of magnitude faster than the previously reported unblocking rate constant of extracellular Mg2+ (Mgo2+) in the physiological voltage range, and their voltage dependencies are of opposite signs. These findings are consistent with the hypothesis that there are separate binding sites in the channel for Mgi2+ and Mgo2+. 6. Based on the blocking kinetics of Mgi2+ and Mgo2+, an energy profile of three barriers and two binding sites for Mg2+ is proposed.
The upward trend in women’s college-going: the role of teenagers’ anticipated future labour force attachment

ABSTRACT This article focuses on the role of teenagers’ anticipated labour force participation in explaining the upward trend in U.S. women’s college-going. A simple conceptual model implies that individuals with more anticipated lifetime hours of work are more likely to invest in college education. My analysis using data from three National Longitudinal Surveys supports the theoretical implication. This finding, combined with the trend towards higher work expectations of young women across birth cohorts, may account in part for the upward trends in women’s college attendance and completion.
SARS (Severe Acute Respiratory Syndrome): reflective practice of a nurse manager

Aims and objectives. This paper describes the reflective practice of a nurse manager in Hong Kong in supporting frontline nurses to overcome the crisis of SARS. Background. SARS infection was a crisis for everyone in endemic areas because of its threat to physical and emotional health. Hong Kong was the second leading endemic area in the world. Inadequate supplies of protective devices and the death of a nurse infected with SARS triggered nurses’ negative emotions. Methods. A model of structured reflection was adopted to examine one's practice. A problem‐solving model for crisis intervention was integrated into the reflective stage of structured reflection. Results. Promotion of nurses’ safety and emotional stability were the major goals in handling the crisis. Strategies were employed including self‐awareness, empowerment and team building, information sharing, provision of personal protective equipment and emotional support for frontline nurses. Conclusions. SARS infection threatens the physical and emotional health of nurses. From a positive perspective, such a crisis created an opportunity to learn and grow in terms of ethical, personal and aesthetic arenas. Relevance to clinical practice. SARS epidemic raised worldwide attention and challenged the Hong Kong's health care system. Reflective practice is useful to guide and examine nurses’ professional action during the crisis, and to put the experience into a learning perspective.
Optimal imaging strategies to assess coronary blood flow and risk for patients with coronary artery disease

Purpose of review This review is meant as a balanced summary of the current state of cardiac magnetic resonance (CMR) perfusion imaging in assessing alterations in myocardial blood flow due to coronary artery disease (CAD). We aim to provide first an accessible technical overview of first-pass CMR perfusion imaging and contrast it with other conventional perfusion imaging modalities, and then address the potential advantages of CMR for a qualitative assessment of perfusion defects, as well as quantitative blood flow measurements. Most recent results from clinical trials on the utility of CMR perfusion and novel directions will be explored. Recent findings Recent results of the first multicenter multivendor CMR perfusion study demonstrated superior diagnostic utility in detecting CAD by CMR compared with conventional nuclear single-photon emission computed tomography. Several large clinical trials provide additional evidence indicating the strong prognostic implications when CMR perfusion was performed in a clinical setting in patients with an intermediate clinical likelihood of CAD. A negative adenosine stress CMR perfusion study conferred a favorable 3-year prognosis towards nonfatal myocardial infarction or cardiac death. Summary CMR perfusion imaging during the first pass of gadolinium-based contrast agents has undergone many technical improvements and levels of clinical validation. Rapidly increasing clinical use worldwide over the last years in diagnosing chest pain syndromes supports the role of CMR in a comprehensive and efficient noninvasive assessment of altered myocardial physiology in CAD.