Miracle-dz/UniFAR-FTUs huggingface dataset:
Bone Turnover in Vertebral Fractures: Does it Effect the Decision of Surgery?

Background and Aim: Instrumentation is commonly used in spinal surgery to stabilize the fracture. In the present study, we aimed to compare the early and late changes seen in bone production and degradation products in patients with traumatic spinal fracture who had been treated surgically or conservatively. Materials and Methods: Forty-three patients were admitted to the Neurosurgery Department with thoracolumbar or lumbar fracture in this prospective study. Patients were divided into two groups of surgically treated (n = 23) and nonsurgically/conservatively treated (n = 20) patients. The early and late changes seen in bone production and degradation products were compared in patients with traumatic spinal fracture who had been treated surgically or conservatively. Results: In conservatively treated patients, although osteocalcin level was slightly increased and deoxypiridinoline (DPD)/creatinine was slightly decreased after the treatment, the difference was not statistically significant (P = 0.08 and P = 0.539, respectively). There is no significant difference between admission time, posttreatment late period osteocalcin level, and DPD/creatinine ratio between the two group of patients (P = 0.215 and P = 0.236, respectively). Conclusion: We suggest that the healing and fusion processes in fractured vertebrae not only followed by the radiological examination but also by noninvasive biochemical changes seen in the serum levels of bone formation and resorption markers.
Glaucoma Pathogenesis and Neurotrophins: Focus on the Molecular and Genetic Basis for Therapeutic Prospects

BACKGROUND Retinal ganglion cell (RGC) degeneration is a major feature of glaucoma pathology. Neuroprotective approaches that delay or halt the progression of RGC loss are needed to prevent vision loss which can occur even after conventional medical or surgical treatments to lower intraocular pressure. OBJECTIVE The aim of this review was to examine the progress in genetics and cellular mechanisms associated with endoplasmic reticulum (ER) stress, RGC dysfunction and cell death pathways in glaucoma. MATERIALS AND METHODS Here, we review the involvement of neurotrophins like brain derived neurotrophic factor (BDNF) and its high affinity receptor tropomyosin receptor kinase (TrkB) in glaucoma. The role of ER stress markers in human and animal retinas in health and disease conditions is also discussed. Further, we analysed the literature highlighting genetic linkage in the context of primary open angle glaucoma and suggested mechanistic insights into potential therapeutic options relevant to glaucoma management. RESULTS The literature review of the neurobiology underlying neurotrophin pathways, ER stress and gene associations provide critical insights into association of RGCs death in glaucoma. Alteration in signalling pathway is associated with increased risk of misfolded protein aggregation in ER promoting RGC apoptosis. Several genes that are linked with neurotrophin signalling pathways have been reported to be associated with glaucoma pathology. CONCLUSION Understanding genetic heterogeneity and involvement of neurotrophin biology in glaucoma could help to understand the complex pathophysiology of glaucoma. Identification of novel molecular targets will be critical for drug development and provide neuroprotection to the RGCs and optic nerve.
An atlas of Wnt activity during embryogenesis in Xenopus tropicalis

Wnt proteins form a family of highly conserved secreted molecules that are critical mediators of cell-cell signaling during embryogenesis. Partial data on Wnt activity in different tissues and at different stages have been reported in frog embryos. Our objective here is to provide a coherent and detailed description of Wnt activity throughout embryo development. Using a transgenic Xenopus tropicalis line carrying a Wnt-responsive reporter sequence, we depict the spatial and temporal dynamics of canonical Wnt activity during embryogenesis. We provide a comprehensive series of in situ hybridization in whole-mount embryos and in cross-sections, from gastrula to tadpole stages, with special focus on neural tube, retina and neural crest cell development. This collection of patterns will thus constitute a valuable resource for developmental biologists to picture the dynamics of Wnt activity during development.
Roadside Unit Caching: Auction-Based Storage Allocation for Multiple Content Providers

Recent improvements in vehicular ad hoc networks are accelerating the realization of intelligent transportation system (ITS), which not only provides road safety and driving efficiency, but also enables infotainment services. Since data dissemination plays an important part in ITS, recent studies have found caching as a promising way to promote the efficiency of data dissemination against rapid variation of network topology. In this paper, we focus on the scenario of roadside unit (RSU) caching, where multiple content providers (CPs) aim to improve the data dissemination of their own contents by utilizing the storages of RSUs. To deal with the competition among multiple CPs for limited caching facilities, we propose a multi-object auction-based solution, which is sub-optimal and efficient to be carried out. A caching-specific handoff decision mechanism is also adopted to take advantages of the overlap of RSUs. Simulation results show that our solution leads to a satisfactory outcome.
Major depression, chronic minor depression, and the five‐factor model of personality

Fifty‐eight outpatients with major depression completed the NEO Personality Inventory at intake (time 1) and after up to three months of anti‐depressant treatment (time 2). Within this group, 26 patients met additional Research Diagnostic Criteria for chronic minor depression. Repeated‐measures analyses revealed significant decreases in Neuroticism scores, and significant increases in Extraversion and Conscientiousness scores, from time 1 to time 2 for both patient groups. In addition, despite similar symptom severity at time 2, the patients with major depression+chronic minor depression scored significantly higher on the Angry Hostility facet of Neuroticism and significantly lower on Agreeableness than those with major depression alone. We suggest from these findings that Angry Hostility and low Agreeableness may represent a trait vulnerability in individuals with chronic minor depression that persists even following remission of the major depressive state, and that this may help to explain their high rates of relapse and recurrence. Copyright © 2002 John Wiley & Sons, Ltd.
Towards a chip scale neurostimulator: System architecture of a current-driven 98 channel neurostimulator via a two-wire interface

With more clinical trials proving viability of visual prosthesis follows the demand for higher resolution devices. As the number of electrodes increases, due to surgical difficulties, it is preferred to keep their length short by placing the implant close to the stimulation site, where there are considerable constraints on device size. On the contrary, the physical volume of the implant generally increases with increasing number of electrodes. Splitting the implant into two modules and placing only the essential circuits near the site of stimulation solves the aforementioned problem. However now the problem is redirected to the robustness and the safety of the interface joining these modules. A novel two-wire interface driving a 98 channel neurostimulator incorporating the split-architecture is presented. The stimulator is provided with both power and data by sending square current waveforms via the two-wire interface. The stimulator itself is fabricated using 0.35 μm HVCMOS technology and occupies 4.9 × 4.9 mm2 and requires no external decoupling capacitor.
Testosterone and Self-Reported Dominance Interact to Influence Human Mating Behavior

In this study, 76 men came into the lab in pairs and engaged in a 7-minute videotaped mate competition for the attention of an attractive female confederate. Pre-competition testosterone (T) levels were positively associated with men’s dominance behaviors and with how much the confederate indicated that she “clicked” with each participant. Dyadic analyses showed that self-reported dominance moderated the effects of T on one’s own dominance behaviors and on opponents' dominance behaviors. Specifically, among men high in self-reported dominance, there was a strong positive association between T and their own dominance behaviors and a strong negative association between T and opponents' dominance behaviors. However, among men low in self-reported dominance, there was no association between T and dominance behaviors. These findings provide novel evidence linking T with evolutionarily adaptive behaviors in humans and suggest that T interacts with people’s explicit dominance motives to regulate behaviors that enhance mating success.
A process model for implementing information systems security governance

Purpose The frequent and increasingly potent cyber-attacks because of lack of an optimal mix of technical as well as non-technical IT controls has led to increased adoption of security governance controls by organizations. The purpose of this paper, thus, is to construct and empirically validate an information security governance (ISG) process model through the plan–do–check–act (PDCA) cycle model of Deming. Design/methodology/approach This descriptive research using an interpretive paradigm follows a qualitative methodology using expert interviews of five respondents working in the ISG domain in United Arab Emirates (UAE) to validate the theoretical model. Findings The findings of this paper suggest the primacy of the PDCA Deming cycle for initiating ISG through a risk-based approach assisted by industry-wide best practices in ISG. Regarding selection of ISG frameworks, respondents preferred to have ISO 27K supported by NIST as the core framework with other relevant ISG frameworks/standards forming the peripheral layer. The implementation focus of the ISG model is on mapping ISO 27K/NIST IT controls relevant IT controls selected from ISG frameworks from a horizontal and vertical perspective. Respondents asserted the automation of measurement and control mechanism through automation to assist in the feedback loop of the PDCA cycle. Originality/value The validated model helps academics and practitioners gain insight into the methodology of the phased implementation of an information systems governance process through the PDCA model, as well as the positioning of ITG and ITG frameworks in ISG. Practitioners can glean valuable insights from the empirical section of the research where experts detail the success factors, the sequential steps and justification of these factors in the ISG implementation process.
Cognitive, functional and physical activity impairment in elderly with Alzheimer's disease

ABSTRACT Alzheimer's Disease (AD) is a progressive degenerative disorder that negatively affects quality of life of patients and family members. Objective: The aim of this study is to compare the cognition, level of physical activity and functioning of elderly individuals with mild AD and those without dementia. Methods: The study comprised 24 elderly with mild AD (mean age = 76.9 ± 5.3 years) and 30 elderly without dementia (mean age = 74.1 ± 5.6 years). The following instruments were applied to evaluate cognitive functions: MMSE; Frontal Assessment Battery; Clock Drawing Test; Corsi Blocks, and Verbal Paired Associates. Event-related potential P300 was used to evaluate cognitive processing. The Modified Baecke Questionnaire For Older Adults was applied to evaluate the level of physical activity together with use of a pedometer for 7 consecutive days. For the evaluation of the functioning, the Direct Assessment of Functional Status-Revised scale and functional tests were used. Results: There was a significant difference between the groups in level of physical activity and functioning, except on the test evaluating flexibility. Conclusion: Elderly with AD had cognitive, functional and physical activity deficits which can manifest even in the early stages of the disease.
Cost function tuning improves muscle force estimation computed by static optimization during walking

Muscle force estimation while a dynamic motor task is carried out still presents open questions. In particular, concerning locomotion, although the inverse dynamic based static optimization has been widely accepted as a suitable method to obtain reliable results, appropriate modifications of the object function may improve results. This paper was aimed at analyzing the sensitivity of estimated muscle forces when modifications of the objective function are adopted to better fit EMG signals of healthy subjects. A 7 links and 9 degrees of freedom biomechanical model accounting for 14 lower limb muscles, grouped in 9 equivalent actuators, was developed. Muscle forces were estimated by using the inverse dynamic based static optimization in which the performance criteria was the sum of muscle stresses raised to a certain n power. This exponent was gradually changed (from 2 to 100) and the agreement between force patterns and EMG signals was estimated by both the correlation coefficient and the Coactivation Index. Results suggested that force estimation can be improved by slightly modifying the cost function. In particular, with respect to adopted data, when the exponent belong to the interval between 2.75 and 4, estimated forces better captured general features of EMG signals. Concluding, a more reliable solution can be obtained by suitably tuning the cost function in order to fit EMG signals.
An O(n log log n)-Time Algorithm for Triangulating a Simple Polygon

Given a simple n-vertex polygon, the triangulation problem is to partition the interior of the polygon into $n - 2$ triangles by adding $n - 3$ nonintersecting diagonals. We propose an $O(n\log \log n)$-time algorithm for this problem, improving on the previously best bound of $O(n\log n)$ and showing that triangulation is not as hard as sorting. Improved algorithms for several other computational geometry problems, including testing whether a polygon is simple, follow from our result.
The association of khat (Catha edulis) chewing and orodental health: A systematic review and meta-analysis.

BACKGROUND It has been claimed that chewing khat (Catha edulis), a plant common in parts of eastern and southern Africa and the Arabian Peninsula, is associated with a range of orodental problems. OBJECTIVE To provide a synthesis of the evidence on the association between khat chewing and orodental health. METHOD A systematic review and meta-analysis of studies that reported on the association of khat chewing and outcomes related to orodental health identified through a systematic search using web-based electronic search engines. RESULTS Nineteen studies were found suitable for this review. Of these, between two and five (based on the type of outcome measured) were suitable for meta-analysis. The rest were used only for qualitative synthesis. A meta-analysis of the association of khat chewing with mucosal white lesions, gum recession, periodontal pocketing and gum bleeding showed that chewing increased the odds of the respective oral problems. However, qualitative synthesis of the findings on the effect of khat chewing on oral micro-organisms showed no evidence that the practice favours the presence of pathogenic micro-organisms in the oral cavity - instead, it seems to favour the proliferation of micro-organisms compatible with orodental health. CONCLUSION Khat chewing is associated with adverse orodental health outcomes. While literature on the topic is scarce and there is a need for generation of more evidence from different countries, on the basis of the evidence accumulated to date, public health officials and health practitioners should consider khat a threat to orodental health and take appropriate action.
Kite Generator System Modeling and Grid Integration

This paper deals principally with the grid connection problem of a kite-based system, named the “Kite Generator System (KGS). ” It presents a control scheme of a closed-orbit KGS, which is a wind power system with a relaxation cycle. Such a system consists of a kite with its orientation mechanism and a power transformation system that connects the previous part to the electric grid. Starting from a given closed orbit, the optimal tether's length rate variation (the kite's tether radial velocity) and the optimal orbit's period are found. The trajectory-tracking problem is not considered in this paper; only the kite's tether radial velocity is controlled via the electric machine rotation velocity. The power transformation system transforms the mechanical energy generated by the kite into electrical energy that can be transferred to the grid. A Matlab/simulink model of the KGS is employed to observe its behavior, and to insure the control of its mechanical and electrical variables. In order to improve the KGS's efficiency in case of slow changes of wind speed, a maximum power point tracking (MPPT) algorithm is proposed.
Manufacture of graded porosity foams: simulation of local ultrasonic pressure and comparison with experimental results

The manufacture of polymeric solid foams with an engineered distribution of mechanical properties has been possible by irradiating ultrasound on a viscoelastic reacting mixture. Structures with a heterogeneous pore size distribution offer great advantages when compared to homogeneous distributions in many applications that require strength with minimal amount of material (e.g. airplane wings). However, manufacturing solutions lag well behind the demand of these components. Sonication has been recently demonstrated as a potential technique that can support these materials fabrication processes. The mechanism involves bubble growth in a polymeric melt undergoing foaming that is influenced by the ultrasonic environment (i.e. sound pressure, frequency and exposure time). Once the foam solidifies, the final porosity distribution within the solid reflects the sonication conditions. In order to obtain sophisticated distributions of porosity and porosity gradients, fine control on the acoustic pressure field has to be achieved. This paper presents an attempt to correlate acoustic pressure to porosity gradation by comparison of simulated acoustic field and engineered porosity analysed on experimental polyurethane foams. COMSOL Multiphysics™ has been used to recreate the process in the irradiation chamber; and the acoustic fields, both in the environment and the reaction vessel, have been simulated and validated. Results from this study will allow the optimisation of the manufacturing process of functionally tailored materials with the sonication method.
Reduced Graphene Oxide Thin Films with Very Large Charge CarrierMobility Using Pulsed Laser Deposition

Large area reduced graphene oxide (RGO) thin films have been grown using pulsed laser deposition (PLD) technique. A very large carrier mobility of 372 cm2 V-1s-1 has been observed in a PLD grown RGO thin film with a large sp2 carbon fraction of 87% along with narrow Raman 2D peak profile. The fraction of sp2 carbon and carbon/oxygen ratios are tuned through PLD growth parameters, and these are estimated from X-ray photoelectron spectroscopy (XPS) data. The electrical properties of the RGO thin films are comprehended by the intensity ratios between different optical phonon vibrational modes of Raman Spectra. The photoluminescence spectra also indicate a less intense and broader blue fluorescence spectrum detecting the presence of miniature sized sp2 domains in the near vicinity of π* electronic states which favor the variable range hopping transport phenomena. This study on large area RGO thin films with very large carrier mobility fabricated by PLD process will be very useful for high mobility electronic device applications and could open a roadmap for further extensive research in functionalized 2D materials.
Effects of levothyroxine on bone mineral density, muscle force, and bone turnover markers: a cohort study.

CONTEXT Previous studies of the effects of levothyroxine (LT(4)) therapy on bone and bone metabolism have provided conflicting results. OBJECTIVE This study evaluated the potential effects and dose-response relationship of LT(4) therapy on bone mineral density (BMD) as well as bone and muscle strength. DESIGN AND SETTING We conducted a prospective, nonrandomized, controlled cohort study with 1.1 ± 0.2-yr follow-up at an academic outpatient clinic in Germany. PARTICIPANTS Ninety-seven men and premenopausal women were enrolled in the study after thyroidectomy and radioiodine remnant ablation for well-differentiated thyroid carcinoma (DTC) or strumectomy for nontoxic goiter. Patients were matched with 89 healthy controls. INTERVENTIONS Twenty-eight men and 46 women on TSH-suppressive doses of LT(4) had DTC, and 23 women were on LT(4) replacement therapy for nontoxic goiter. MAIN OUTCOME MEASURE This study assessed total and trabecular volumetric BMD (vBMD) as well as bone strength at the ultradistal radius, areal BMD at the lumbar spine and both hips, and the grip strength of the nondominant forearm. The dependent variables were annualized rates of change. RESULTS LT(4) therapy did not impair the areal BMD, bone strength, or grip strength of patients compared with controls. Women with DTC showed a significant loss of total vBMD, whereas men with DTC developed marginally less bone strength than women. Carboxy-terminal telopeptide indicated greater bone resorption in DTC patients compared with controls. CONCLUSIONS There was little evidence of adverse LT(4) effects on bone; however, premenopausal women with DTC might be at risk for reduced vBMD in their ultradistal radii.
Effect of Altered Retinal Cones/Opsins on Refractive Development under Monochromatic Lights in Guinea Pigs

Purpose To analyze the changes of refraction and metabolism of the retinal cones under monochromatic lights in guinea pigs. Methods Sixty guinea pigs were randomly divided into a short-wavelength light (SL) group, a middle-wavelength light (ML) group, and a white light (WL) group. Refraction and axial length were measured before and after 10-week illumination. The densities of S-cones and M-cones were determined by retinal cone immunocytochemistry, and the expressions of S-opsins and M-opsins were determined by real-time PCR and Western blot. Results After 10-week illumination, the guinea pigs developed relative hyperopia in the SL group and relative myopia in the ML group. Compared with the WL group, the density of S-cones and S-opsins increased while M-cones and M-opsins decreased in the SL group (all, p < 0.05); conversely, the density of S-cones and S-opsins decreased while M-cones and M-opsins increased in the ML group (all, p < 0.05). Increased S-cones/opsins and decreased M-cones/opsins were induced by short-wavelength lights. Decreased S-cones/opsins and increased M-cones/opsins were induced by middle-wavelength lights. Conclusions Altered retinal cones/opsins induced by monochromatic lights might be involved in the refractive development in guinea pigs.