Miracle-dz/UniFAR-FTUs huggingface dataset:
Secondary Acute non Lymphoid Leukemia in Patients Treated for non Hodgkin's Lymphoma: No Risk of Therapy-Related Anll after Provecip Schedule

The present study was undertaken to evaluate the frequency, characteristics and actuarial risk of secondary acute non lymphoid leukemia (s-ANLL) in 141 patients treated for non Hodgkin's lymphoma with different modalities. One hundred and twenty-four patients received chemotherapy according to PROVECIP protocol (9). Of these, 15 also received as induction treatment a local nodal irradiation and 33 an extended field radiotherapy. Seventeen out of 141 were treated by total body irradiation. Of these, 15 relapsed and received salvage chemotherapy. Sixteen of the 124 patients treated with PROVECIP also underwent different chemotherapeutic programs as salvage treatment. Of the entire population studied, 2 patients developed an s-ANLL, 45 and 63 months after diagnosis of NHL. The type of treatment significantly affected the occurrence of s-ANLL, since both leukemias occurred in patients treated with total body irradiation, given alone or followed by chemotherapy. The actuarial risk at 8 years was 5.24% in the whole group, whereas it greatly increased in the group of patients treated with total body irradiation (24%). Conversely, no risk was found in the group treated with PROVECIP, alone, with additional chemotherapy, or with associated local or extended field radiotherapy.
The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments

The proprotein convertase PC5 is encoded by multiple mRNAs, two of which give rise to the COOH-terminal variant isoforms PC5-A (915 amino acids [aa]) and PC5-B (1877 aa). To investigate the differences in biosynthesis and sorting between these two proteins, we generated stably transfected AtT-20 cell lines expressing each enzyme individually and examined their respective processing pattern and subcellular localization. Biosynthetic analyses coupled to immunofluorescence studies demonstrated that the shorter and soluble PC5-A is sorted to regulated secretory granules. In contrast, the COOH- terminally extended and membrane-bound PC5-B is located in the Golgi. The presence of a sorting signal in the COOH-terminal 38 amino acids unique to PC5-A was demonstrated by the inefficient entry into the regulated secretory pathway of a mutant lacking this segment. EM of pancreatic cells established the presence of immunoreactive PC5 in glucagon-containing granules, demonstrating the sorting of this protein to dense core secretory granules in endocrine cells. Thus, a single PC5 gene generates COOH-terminally modified isoforms with different sorting signals directing these proteins to distinct subcellular localization, thereby allowing them to process their appropriate substrates.
The Cohort and Speechify Libraries for Rapid Construction of Speech Enabled Applications for Android

Despite the prevalence of libraries that provide speech recognition and text-tospeech synthesis “in the cloud”, it remains difficult for developers to create user-friendly, consistent spoken language interfaces to their mobile applications. In this paper, we present the Speechify / Cohort libraries for rapid speech enabling of Android applications. The Speechify library wraps several publicly available speech recognition and synthesis APIs, incorporates state-of-the-art voice activity detection and simple and flexible hybrid speech recognition, and allows developers to experiment with different modes of user interaction. The Cohort library, built on a stripped-down version of OpenDial, facilitates flexible interaction between and within “Speechified” mobile applications.
Civets Are Equally Susceptible to Experimental Infection by Two Different Severe Acute Respiratory Syndrome Coronavirus Isolates

ABSTRACT Severe acute respiratory syndrome (SARS) was caused by a novel virus now known as SARS coronavirus (SARS-CoV). The discovery of SARS-CoV-like viruses in masked palm civets (Paguma larvata) raises the possibility that civets play a role in SARS-CoV transmission. To test the susceptibility of civets to experimental infection by different SARS-CoV isolates, 10 civets were inoculated with two human isolates of SARS-CoV, BJ01 (with a 29-nucleotide deletion) and GZ01 (without the 29-nucleotide deletion). All inoculated animals displayed clinical symptoms, such as fever, lethargy, and loss of aggressiveness, and the infection was confirmed by virus isolation, detection of viral genomic RNA, and serum-neutralizing antibodies. Our data show that civets were equally susceptible to SARS-CoV isolates GZ01 and BJ01.
A Decomposition Method for Entity Relationship Models: A Systems Theoretic Approach

This paper defines a method for decomposing a large Entity Relationship model into a hierarchy of models of manageable size. The purpose of this is to improve user understanding and simplify documentation and maintenance. We define the problem as an instance of the general systems decomposition problem or systems simplification problem. We first define a set of principles for decomposing Entity Relationship models based on systems theory and human information processing. These define the desirable characteristics of a decomposition, and may be used to evaluate the quality of a decomposition and to choose between alternatives. We then define a procedure which can be used by humans to develop a relatively optimal (“good”) decomposition. Finally, we define a genetic algorithm which automatically finds an optimal decomposition based on the principles defined.
International Journal of Computer Science and Technology 507

The actual idea of a telephony structure shows a Private Automatic Branch Exchange (PABX) directly controlling a whole communication system. Ringing and caller identification signals, voltage setting for the phone sets among other important parameters all are transmitted using twisted pair cables that have to be installed and distributed along the building. The use of existing indoor power lines as the communication channel benefits the installation of the telephony system because the network infrastructure is already mounted. However, power lines behave noisy and aggressive when transmitting high frequency signals and in order to establish effective communication, modern modulation and transmissions schemes have to be implemented. With this new conception, the transmission scenario changes completely and so does the system. This paper presents the idea for the design of an analog modular electronic interface that is intended to create a sort of correlation between the current standards for conventional communication schemes and this system, which uses power lines to communicate between its peers. I. Introduction With the explosion of power lines communication that has been taking place recently people around the world research unsparingly to take advantage of this technology. The telephony system that is being implemented here uses existing power lines of an indoor establishment to communicate between its users as a way to decrement the prices of the design since there is no need of mounting the network. In this paper we describe the challenges ahead of the technology change as well as the solution approach in order to implement the system. The system overview, the transmission scheme to use, the way the PABX communicates with the users, how to interface to the Public System Telephony Network (PSTN), the way the ring signal is generated, the implementation of the caller identification feature and how to interface to the standards existing phone sets available in the market are some of the issues that are treated in this paper.
Contexts of Collaborative Musical Experiences

We explore a variety of design criteria applicable to the creation of collaborative interfaces for musical experience. The main factor common to the design of most collaborative interfaces for novices is that musical control is highly restricted, which makes it possible to easily learn and participate in the collective experience. Balancing this trade off is a key concern for designers, as this happens at the expense of providing an upward path to virtuosity with the interface. We attempt to identify design considerations exemplified by a sampling of recent collaborative devices primarily oriented toward novice interplay. It is our intention to provide a non-technical overview of design issues inherent in configuring multiplayer experiences, particularly for entry-level players.
Road conditions in the design of vehicle speed control using the LPV method

The paper focuses on the design of a new adaptive cruise control which takes into consideration the knowledge of the inclinations of the road along the track of the vehicle. The controlled system incorporates the brake and the traction forces. By choosing the velocity of the vehicle fitting in with the inclinations of the road the number of unnecessary accelerations and brakes can be reduced, thus so can the operations of the actuators of the vehicles, i.e. the powertrain and the brake system. The longitudinal dynamics of the vehicle is formulated in a control-oriented linear model, which contains the longitudinal control force and disturbances such as the aerodynamic force, rolling resistance and road slope. If the inclination of the road surface is assumed to be known, it is considered in the calculation of the velocity tracking and the reference velocity. In the model the nonlinear properties of the predicted road inclinations are considered together with the safety requirements. The control system is designed by using LPV/ℋ∞ control theory. The operation of the method is demonstrated through simulation examples in Matlab/Simulink and CarSim environments.
Modification of the cascade model for regulation of vaccinia virus gene expression: purification of a prereplicative, late-stage-specific transcription factor

In vivo and in vitro studies have provided evidence that vaccinia virus late gene transcription factors are intermediate gene products synthesized exclusively after DNA replication. Here, we describe an additional transcription factor (P3 factor) that stimulates late gene transcription between 10- and 40-fold but is made in the absence of viral DNA replication. P3 factor activity was not detected either in uninfected cells or in purified virions. A > 1,500-fold purification of P3 factor was achieved by column chromatography of cytoplasmic extracts prepared from cells infected with vaccinia virus in the presence of a DNA replication inhibitor. P3 factor was stage specific, since it could not substitute for early or intermediate transcription factors. Evidence that late stage-specific transcription factors are made both before and after DNA replication necessitates a modification of the cascade model for vaccinia virus gene regulation.
A neutral‐niche theory of nestedness in mutualistic networks

Recently, there has been a vigorous interest in community ecology about the structure of mutualistic networks and its importance for species persistence and coevolution. However, the mechanisms shaping mutualistic networks have been rarely explored. Here we extend for the first time the neutral theory of biodiversity to a multi trophic system. We focus on nestedness, a distinctive pattern of mutualistic community assembly showing two characteristics, namely, asymmetrical specialization (specialists interacting with generalists) and a generalist core (generalists interacting with generalists). We investigate the importance of relative species abundance (RSA) for the nested assembly of plant–animal mutualistic networks. Our results show that neutral mutualistic communities give rise to networks considerably more nested than real communities. RSA explains 60–70% of nested patterns in two real communities studied here, while 30–40% of nestedness is still unexplained. The nested pattern in real communities is better explained when we introduce interaction-specific species traits such as forbidden links and intensity of dependence (relative importance of fruits for the diet of a frugivore) in our analysis. The fact that neutral mutualistic communities exhibit a perfectly nested structure and do not show a random or compartmentalized structure, underlines the importance of RSA in the assembly of mutualistic networks.
Can a change in policy reduce emergency hospital admissions? Effect of admission avoidance team, guideline implementation and maximising the observation unit

Background: Reduction in admissions is an important aim of emergency department working policy to overcome the problems of a shortage of inpatient beds, overcrowding, rising costs and exhausted resources. A new policy was instituted in the emergency department of a hospital in Kuwait with the following components: (1) an admission avoidance team of emergency department doctors; (2) implementation of disease management guidelines; and (3) maximising the use of an emergency department observation unit. Methods: The effects of this policy on reduction in admission rates for total medical admissions and for chest pain, bronchial asthma, heart failure, pneumonia and pyelonephritis as selected samples of common medical conditions were prospectively studied over a period of 3 years from institution of the policy and compared with the 3-year period before the policy was instituted. Results: There was a significant reduction in admission rates after institution of the new policy, with a relative reduction of 35.9% for total medical admissions, 52.7% for chest pain, 49.2% for bronchial asthma, 34.7% for heart failure, 59.1% for pneumonia and 43.3% for pyelonephritis compared with the period before the policy was instituted. Conclusion: A multidisciplinary emergency department policy, using as much available evidence as possible, was successful in significantly reducing medical hospital admissions in spite of the rising numbers of patients visiting the emergency department and observation unit.
Physical Database Design for an Object-Oriented Database System

Object oriented database systems typically o er a variety of structuring capabilities to model complex objects This exibility together with type or class hierarchies and computed attributes methods poses a high demand on the physical design of object oriented databases Similar to traditional databases it is hardly ever true that the conceptual structure of the database is also a good that is e cient internal one Rather data representing the conceptual objects may be structured completely di erent for performance reasons Database systems providing a reasonable amount of data indepen dence allow a physical design that di ers from the logical structure signi cantly Hence the performance of the system can be tailored to the overall transaction load faced The paper presents choices for physical designs that make use of a complex storage model an extended nested relational model A rst prototype of a physical design optimizer is also presented
Americans' attitudes toward mental health treatment seeking: 1990-2003.

OBJECTIVE This study examined recent trends in Americans' attitudes toward mental health treatment seeking and beliefs about the effectiveness of such treatment. METHODS Data on attitudes and beliefs from two representative surveys of the U.S. general population were compared. Samples included 5,388 participants from the National Comorbidity Survey (NCS) in 1990-1992 and 4,319 from the National Comorbidity Survey-Replication (NCS-R) in 2001-2003. RESULTS Participants in the 2001-2003 survey were more willing than those in the 1990-1992 survey to seek professional help for mental health problems (41.4% reported that they would "definitely go" for professional help in 2001-2003, compared with 35.6% in 1990-1992). Participants in the more recent survey were also more comfortable talking with a professional about personal problems (32.4% in 2001-2003 reported feeling "very comfortable," compared with 27.1% in 1990-1992) and were less likely to say that they would be embarrassed if others found out about it (40.3% reported being "not at all embarrassed" in 2001-2003, compared with 33.7% in 1990-1992). Attitudes of younger participants improved more than attitudes of middle-aged participants. Public beliefs about the effectiveness of mental health treatment and the likelihood of recovery without treatment changed little across surveys. CONCLUSIONS Mental health treatment seeking has become more acceptable over the past decade, and perceived stigma associated with it has declined. These changes in public attitudes have likely contributed to the growing demand for mental health services in the United States and will continue to do so in the coming years.
Simple, Effective, but Out of Reach? Public Health Implications of HCV Drugs.

The results of four clinical trials showing the excellent safety and efficacy of a 12-week course of sofosbuvir (an NS5B inhibitor licensed in the United States in 2013) and velpatasvir (a new NS5A inhibitor) in treating patients with hepatitis C infection (HCV) are reported now in the Journal.1–3 In two of these studies, ASTRAL-1 and ASTRAL-2, 97 to 100% of patients with HCV genotype 1a, 1b, 2, 4, 5, or 6 had a sustained virologic response at 12 weeks after the end of therapy, a marker that is indicative of virologic cure. Similar efficacy was observed among patients .
A New Corpus for Context-Dependent Semantic Parsing

Semantic parsing is the task of translating natural language (NL) utterances into a machineinterpretable meaning representation (MR). Most approaches to this task have been developed and evaluated on a small number of existing corpora. While these corpora have made progress in semantic parsing possible, most of them cover rather narrow domains and context is rarely considered. In this paper we present a new set of guidelines for context-dependent semantic parsing and describe the annotation of a semantic parsing corpus. This new corpus covers a wider domain, namely tourismrelated activities in a city, and consists of 17 dialogs containing 2374 user utterances.
Combination of behaviour therapy with fluvoxamine in comparison with behaviour therapy and placebo

Background We investigated whether the combination of multimodal behaviour therapy (BT) with fluvoxamine is superior to BTand placebo in the acute treatment of severely ill in-patients with obsessive-compulsive disorder (OCD). Method In a randomised, double-blind design, 30 patients were treated for nine weeks with BT plus placebo and 30 patients with BT plus fluvoxamine (maximum dosage 300 mg, mean dose 288.1 mg). BT included exposure with response prevention, cognitive restructuring and development of alternative behaviours. Results Both groups showed a highly significant symptom reduction after treatment. There were no significant differences between the groups concerning compulsions. Obsessions were significantly more reduced in the fluvoxamine and BT group than in the placebo and BT group. Furthermore, the group BT plus fluvoxamine showed a significantly higher response rate (87.5 v. 60%) according to a previously defined response criterion. Severely depressed patients with OCD receiving BT plus placebo presented a significantly worse treatment outcome (Y–BOCS scores) than all other groups. Conclusions The results suggest that BTshould be combined with fluvoxamine when obsessions dominate the clinical picture and when a secondary depression is present.
Formally verified Byzantine agreement in presence of link faults

This paper shows that deterministic consensus in synchronous distributed systems with link faults is possible, despite the impossibility result of Gray (1978). Instead of using randomization, we overcome this impossibility by moderately restricting the inconsistency that link faults may cause system-wide. Relying upon a novel hybrid fault model that provides different classes of faults for both nodes and links, we provide a formally verified proof that the m+1-round Byzantine agreement algorithm OMH (Lincoln and Rushby (1993)) requires n > 2f/sub l//sup s/ + f/sub l//sup r/ + f/sub l//sup ra/ + 2(f/sub a/ + f/sub s/) + f/sub o/ + f/sub m/ + m nodes for transparently masking at most f/sub l//sup s/ broadcast and f/sub l//sup r/ receive link faults (including at most f/sub l//sup ra/ arbitrary ones) per node in each round, in addition to at most f/sub a/, f/sub s/, f/sub o/, f/sub m/ arbitrary, symmetric, omission, and manifest node faults, provided that m /spl ges/ f/sub a/ + f/sub o/ + 1. Our approach to modeling link faults is justified by a number of theoretical results, which include tight lower bounds for the required number of nodes and an analysis of the assumption coverage in systems where links fail independently with some probability p.
Effects of Random Allocation to Vitamin E Supplementation on the Occurrence of Venous Thromboembolism: Report From the Women’s Health Study

Background— Supplementation with vitamin E may antagonize vitamin K in healthy adults, but it is unclear whether intake of vitamin E decreases the risk of venous thromboembolism (VTE). Methods and Results— The Women’s Health Study randomized 39 876 women ≥45 years of age to receive 600 IU of natural source vitamin E or placebo on alternate days. Before randomization, 26 779 participants gave blood samples, which were used to determine factor V Leiden, G20210A prothrombin, and 677C>T MTHFR polymorphisms. Documented VTE (including deep vein thrombosis or pulmonary embolism) and unprovoked VTE (no recent surgery, trauma, or cancer diagnosis) were prospectively evaluated, secondary end points of the trial. During a median follow-up period of 10.2 years, VTE occurred in 482 women: 213 in the vitamin E group and 269 in the placebo group, a significant 21% hazard reduction (relative hazard, 0.79; 95% CI, 0.66 to 0.94; P=0.010). For unprovoked VTE, the hazard reduction was 27% (relative hazard, 0.73; 95% CI, 0.57 to 0.94; P=0.016). In subgroup analyses, the 3% of participants who reported VTE before randomization had a 44% hazard reduction (relative hazard, 0.56; 95% CI, 0.31 to 1.00; P=0.048), whereas women without prior VTE had an 18% hazard reduction (relative hazard 0.82; 95% CI, 0.68 to 0.99; P=0.040). Women with either factor V Leiden or the prothrombin mutation had a 49% hazard reduction associated with vitamin E treatment (relative hazard, 0.51; 95% CI, 0.30 to 0.87; P=0.014). Conclusions— These data suggest that supplementation with vitamin E may reduce the risk of VTE in women, and those with a prior history or genetic predisposition may particularly benefit.
A novel basic helix-loop-helix protein is expressed in muscle attachment sites of the Drosophila epidermis

We have found that a novel basic helix-loop-helix (bHLH) protein is expressed almost exclusively in the epidermal attachments sites for the somatic muscles of Drosophila melanogaster. A Drosophila cDNA library was screened with radioactively labeled E12 protein, which can dimerize with many HLH proteins. One clone that emerged from this screen encoded a previously unknown protein of 360 amino acids, named delilah, that contains both basic and HLH domains, similar to a group of cellular transcription factors implicated in cell type determination. Delilah protein formed heterodimers with E12 that bind to the muscle creatine kinase promoter. In situ hybridization with the delilah cDNA localized the expression of the gene to a subset of cells in the epidermis which form a distinct pattern involving both the segmental boundaries and intrasegmental clusters. This pattern was coincident with the known sites of attachment of the somatic muscles to tendon cells in the epidermis. delilah expression persists in snail mutant embryos which lack mesoderm, indicating that expression of the gene was not induced by attachment of the underlying muscles. The similarity of this gene to other bHLH genes suggests that it plays an important role in the differentiation of epidermal cells into muscle attachment sites.