Miracle-dz/UniFAR-FTUs huggingface dataset:
Nonmitochondrial ATP/ADP Transporters Accept Phosphate as Third Substrate

Chlamydiales and Rickettsiales as metabolically impaired, intracellular pathogenic bacteria essentially rely on “energy parasitism” by the help of nucleotide transporters (NTTs). Also in plant plastids NTT-type carriers catalyze ATP/ADP exchange to fuel metabolic processes. The uptake of ATP4-, followed by energy consumption and the release of ADP3-, would lead to a metabolically disadvantageous accumulation of negative charges in form of inorganic phosphate (Pi) in the bacterium or organelle if no interacting Pi export system exists. We identified that Pi is a third substrate of several NTT-type ATP/ADP transporters. During adenine nucleotide hetero-exchange, Pi is cotransported with ADP in a one-to-one stoichiometry. Additionally, Pi can be transported in exchange with solely Pi. This Pi homo-exchange depends on the presence of ADP and provides a first indication for only one binding center involved in import and export. Furthermore, analyses of mutant proteins revealed that Pi interacts with the same amino acid residue as the γ-phosphate of ATP. Import of ATP in exchange with ADP plus Pi is obviously an efficient way to couple energy provision with the export of the two metabolic products (ADP plus Pi) and to maintain cellular phosphate homeostasis in intracellular living “energy parasites” and plant plastids. The additional Pi transport capacity of NTT-type ATP/ADP transporters makes the existence of an interacting Pi exporter dispensable and might explain why a corresponding protein so far has not been identified.
The effect of self-care education program on reducing HbA1c levels in patients with type 2 diabetes

Background: Diabetes as the most common diseases caused by metabolic disorders is an important global challenge. This is a disease that requires lifelong self-care because self-care and improved quality of life is cost effective. This study is aimed to determine the impact of self-care education program on reducing HbA1c, type 2 diabetic patients and was conducted in Zahedan. Materials and Methods: This is an experimental study done on 138 diabetic female patients in Zahedan city, in 2011 (1390). This sampling method of patients was based on inclusion and exclusion criteria of the Diabetes Center, at Hazrat Ali Asghar Hospital (AS) in Zahedan. Samples were divided randomly in to two groups: 69 cases and 69 controls. Data collected included validity and reliability confirmed questionnaire. Checklist was based on patients ‘performance of reporting and (HbA1c) testing. Before the educational intervention, the checklist of questions for recording the (HbA1c) test for both the groups were completed, and study samples received 5 sessions of education (with the group discussion and film show) for a month. However, the control group received only routine training. Three months after the educational intervention, both groups completed the questionnaire and the check list and data using SPSS software and the appropriate tests were analyzed. Results: Findings showed that the mean domain scores of area of knowledge, attitude and practice educational groups, were recorded as (46.6 ± 8.57, 46.5 ± 0.86 and 29.06 ± 10.02), respectively. And after education scores of knowledge, attitude and practice were recorded as (52.80 ± 2.20, 12.98 ± 1.02 and 39.69 ± 4.74), respectively, and in study group significant difference (P < 0/001) was seen. Conclusion: Self-care training in striation leads to improve knowledge, attitude and self-care performance of the study samples and also improves the average (HbA1c). Because it seems to increase the active participation of learners in their care that they have experienced with this training method and their motivation enhanced them to learn better self-care. So this type of care education should be given to the attention of nurses and healthcare's staff.
Optical step height and trench depth measurement

Optical profilometer measurements are contact-free and fast. The depth of single high-aspect-ratio trenches and the step height of opaque materials can be measured. Deep trenches (50-225 μm) are measured with a white light interferometer. Shallower trenches and step height profiles are measured with a chromatic white light sensor. A vertical resolution of 6 nm and a lateral resolution of 2 μm make the optical profilometer well suited for larger structures on power semiconductors that are manufactured in the back end of line.
iFORM/eQTL: an ultrahigh-dimensional platform for inferring the global genetic architecture of gene transcripts

Knowledge about how changes in gene expression are encoded by expression quantitative trait loci (eQTLs) is a key to construct the genotype-phenotype map for complex traits or diseases. Traditional eQTL mapping is to associate one transcript with a single marker at a time, thereby limiting our inference about a complete picture of the genetic architecture of gene expression. Here, we implemented an ultrahigh-dimensional variable selection model to build a computing platform that can systematically scan main effects and interaction effects among all possible loci and identify a set of significant eQTLs modulating differentiation and function of gene expression. This platform, named iFORM/eQTL, was assembled by forward-selection-based procedures to tackle complex covariance structures of gene-gene interactions. iFORM/eQTL can particularly discern the role of cis-QTLs, trans-QTLs and their epistatic interactions in gene expression. Results from the reanalysis of a published genetic and genomic data set through iFORM/eQTL gain new discoveries on the genetic origin of gene expression differentiation in Caenorhabditis elegans, which could not be detected by a traditional one-locus/one-transcript analysis approach.
Cathode-Supported All-Solid-State Lithium–Sulfur Batteries with High Cell-Level Energy Density

Bulk-type all-solid-state lithium batteries (ASSLBs) are being considered as a promising technology to improve the safety and energy density of today’s batteries. However, current bulk-type ASSLBs suffer from low cell-level energy density due to the challenges in reducing the electrolyte thickness. In this work, we report cathode-supported ASSLBs with a thin solid electrolyte layer. Starting from a stainless steel mesh-supported Li2S cathode, we are able to build an ASSLB with a ∼100 μm thick Li3PS4 electrolyte reinforced by a Kevlar nonwoven scaffold and with Li metal as the anode. The ASSLB delivers a high capacity with high rate and cycling performances at room temperature. Moreover, the unique cell design also enabled utilization of a thick cathode with a Li2S loading of 7.64 mg cm–2, providing a high cell-level energy density (excluding the current collectors) of 370.6 Wh kg–1 for the first cycle.
Hybrid Color-Texture Space for Image Classification

—This work presents an approach for the construction of a hybrid color-texture space by using mutual information. Feature extraction is done by the Laws ﬁlter with SVM (Support Vectors Machine) as a classiﬁer. The classiﬁcation is applied on the VisTex database and a SPOT HRV (XS) image representing two forest areas in the region of Rabat in Morocco. The result of classiﬁcation obtained in the hybrid space is compared with the one obtained in the RGB color space.
A new hope? Experiences of accessibility of services in deaf and hard-of-hearing audiences post-digital television switchover

One promise of the switchover from analogue to digital television was new accessibility solutions. In the case of deaf and hard-of-hearing audiences who rely on subtitling for comprehension, the digital switchover makes it possible for greater provision of subtitling or improvements in accuracy. Utilizing quantitative data from a questionnaire completed by 339 participants with varying degrees of hearing difficulty in Wales, this article assesses perceptions of subtitling pre- and postdigital switch. A within-group comparison across age groups is also used to assess whether improvements in service are age defined. The results found that difficulties in accessing quality subtitling are still experienced by this audience post-digital switchover and that there are no significant differences in age in experiencing these difficulties. Knowledge of other digital services is subject to a significant difference in age, which indicates more work is required to inform older audience members of the affordances of digital television
Transparent Automation for Assessing and Designing better Interactions between Operators and Partly-Autonomous Interactive Systems

Human Automation Interaction deals with finding the best balance for the allocation of tasks and functions between operators and the systems being operated. Automation is typically addressed at a very high level i.e. at the procedures or tasks that have to be performed to reach a goal. When these automations are not adequately designed (or correctly understood by the operator), they may result in so called automation surprises [30], [36] that degrade, instead of enhance, the overall performance of the operations. However, such previous work on automation surprises have overlooked the importance of automation in order for the operator to trigger these tasks and the fact that an interactive command and control system has to be used. This interactive system usually integrates low level automation that might also result in automation surprises. The paper proposes a stepwise approach for identifying, describing and analyzing the automation level of interaction techniques in an explicit way. This approach provides support for analyzing potential automation surprises that can arise from the interaction technique but also for identifying how to modify them in order to reduce performance degradations due to automation surprises at the interaction level. Based on a classification of interaction techniques we demonstrate that a model-based approach can support the design and assessment of the automation that interaction techniques feature and that is usually hidden from the users.
“Those Are Only Slogans”

This article examines a newspaper and a television debate between a philosopher and two politicians of the extreme rightwing party the Flemish Bloc (Vlaams Blok) in Flanders (Belgium). The debates took place in the summer and autumn of 2004, respectively, after the party had been condemned for racism by the Belgian court. The debates center around the fundamental question asked by the philosopher to what extent and in what way the party has abandoned the views which led to the verdict. The research questions are the following: (a) What tactics are used in this situation, which creates a conflict between the party's ideology and legality? (b) Are implicit meanings uncover-able beneath the surface tactics which give an answer to the philosopher's question? (c) Is the political debating style of the speakers as politicians belonging to an extremist party the same as or different from that of mainstream politicians?
Experimental characterization of an airfoil-based actuator using high-temperature shape memory alloys

This paper reports experimental results of an airfoil-based flap actuator that is actuated using high temperature Nickel-Titanium (NiTi) polycrystal and Copper-Aluminium-Nickel (CuAlNi) single crystal wires with a nominal diameter of 1.5 mm. The stress-free transformation temperatures of the commercially available NiTi wires are Mf = 53°C, Ms = 70°C , As = 95°C , Af = 110°C whereas those for the CuAlNi wires are Mf = 80°C ,Ms = 100.5°C, As = 104.5°C , Af = 117°C. Due to a significantly low electrical resistivity of the CuAlNi, the commonly used joule heating approach for thermal actuation is shelved for a heating coil approach. Uniaxial stress measurements, trailing edge flap deflections and temperature measurements are recorded during a typical heating and cooling cycle using a load cell in line with the SMA wire, a LVDT at the trailing edge tip and a thermocouple on the wire (outside the heating coil). It is seen that actuation by the CuAlNi (with a prestrain = 5.5%) leads to about a 50% higher tip deflection and about a 67% lower cooling time after actuation as compared to the corresponding values for NiTi (with a prestrain = 5.6%). The larger tip deflection is attributed to a higher strain recovery for the CuAlNi as compared to the NiTi during phase transformation whereas the lower actuation time is attributed, in part, to the narrow hysteresis in the stress-free transformation temperatures of the CuAlNi (~ 37°C) as compared to the NiTi (~ 57°C).
International Journal of Nanomedicine Dovepress Development of Antiproliferative Nanohybrid Compound with Controlled Release Property Using Ellagic Acid as the Active Agent

An ellagic acid (EA)–zinc layered hydroxide (ZLH) nanohybrid (EAN) was synthesized under a nonaqueous environment using EA and zinc oxide (ZnO) as the precursors. Powder X-ray diffraction showed that the basal spacing of the nanohybrid was 10.4 Å, resulting in the spatial orientation of EA molecules between the interlayers of 22.5° from z-axis with two negative charges at 8,8′ position of the molecules pointed toward the ZLH interlayers. FTIR study showed that the intercalated EA spectral feature is generally similar to that of EA, but with bands slightly shifted. This indicates that some chemical bonding of EA presence between the nanohybrid interlayers was slightly changed, due to the formation of host–guest interaction. The nanohybrid is of mesopores type with 58.8% drug loading and enhanced thermal stability. The release of the drug active, EA from the nanohybrid was found to be sustained and therefore has good potential to be used as a drug controlled-release formulation. In vitro bioassay study showed that the EAN has a mild effect on the hepatocytes cells, similar to its counterpart, free EA.
Channel parameter extraction methodology for system-level simulator in small cell environments

Small cell networks have many attractive solutions to solve the network overload caused by heavy demands of traffic. To evaluate the performance of systems, a system-level simulator (SLS) is typically used. However, the performance evaluation with a typical channel parameter set which is representing the entire area in SLS shows only the typical performance of the entire area, so that extra field trial is necessary to evaluate realistic deployment performance of a given region. In this paper, a channel parameter extraction methodology is proposed by using a ray tracing tool to evaluate a realistic performance of a target region for SLS.
Data Partitioning on Heterogeneous Multicore Platforms

In this paper, we present two techniques for inter- and intra-node data partitioning aimed at load balancing MPI applications on heterogeneous multicore platforms. For load balancing between the multicore nodes of a heterogeneous multicore cluster, we propose how to define a functional performance model of an individual multicore node as a single computing unit, and use these models for data partitioning between the nodes. For load balancing within a heterogeneous multicore node, we propose a data partitioning technique between cores. Since parallel processes interfere with each other through shared memory, the speed of individual cores cannot be measured independently, and independent performance models cannot be defined for cores. Therefore, for a given problem size, we dynamically evaluate the performance of cores, while they are executing only the computational kernel of parallel application, and partition data proportionally to the observed speed.
Professional Associations, Power and the Building of Electronic Prescription Systems

In this paper we pull together an analysis of power with an analysis of the agency of a Professional Association of Pharmacists in the building of an electronic prescription (EP) system. We frame our analysis of the building process of an EP system in terms of power from the perspective of the pharmacists collective, and particularly, from the perspective of the Catalan Professional Association of Pharmacists (CPAP). What concerns us in this paper is the role of the CPAP in structuring the field of other’s action –namely, community pharmacies which are members of the CPAP and the Catalan Health Service– during the building process. From this perspective, we study power not only in the CPAP’s capacity to influence others through the control of resources that others need, but also in the field of relations that characterize a power arena and in the effect of the ordering work performed by the CPAP. By examining the case from the lens of the circuits of power we identify two kinds of interventions from the CPAP –conservative and transformative–, and distinguish them based on the circuit of power they active and the use of IT they make.
Multi-hop, multi-route power minimisation in ad hoc network

This paper studies the problem of finding the optimal route of a stream between the transmitter and the receiver in an ad hoc network while minimizing the total power consumption. The criterion is the minimum power, and the fact that the stream must reach its destination is used as a constraint. Compared to previous approaches, we introduce more flexibility by allowing the stream to be split between several intermediate destinations, and we do not use the specific approximations (mainly high SNR) required to make the problem convex. Therefore, the main difficulty is due to the non convexity of the problem. In this contribution, we address a simple situation (flat fading channels, constant during the optimization process, simple transmitters and receivers) in order to demonstrate some properties of the problem. Finally, we propose an algorithm which, at least in some cases, is able to overcome the non convexity. Illustrations of the path followed by the algorithm demonstrates that it is able to find the global optimum even is difficult cases.
Geoweb Services for Sharing Modelling Results in Biodiversity Networks

Biodiversity researchers in different institutions deal with predictive models for species distribution. These models are useful for biodiversity conservation policies. Species distribution modelling tools need large datasets from different sources and use many algorithms. To improve biodiversity science, scientists need to share models, data and results, and should be able to reproduce experiments from others. This article presents a geoweb service architecture that supports sharing of modelling results and enables researchers to perform new modelling experiments. We show the feasibility of the proposed architecture by developing a set of prototype services, called Web Biodiversity Collaborative Modelling Services – WBCMS. They provide a set of geospatial web services that support the sharing of species distribution models. The article includes an example of a model instance that explains the WBCMS prototype. We believe that WBCMS shows how to set up a cooperative research network on biodiversity research.
Computational intelligence software for interval type‐2 fuzzy logic

A software tool for interval type‐2 fuzzy logic is presented in this article. The software tool includes a graphical user interface for construction, edition, and observation of the fuzzy systems. The Interval Type‐2 Fuzzy Logic System Toolbox (IT2FLS) has a user‐friendly environment for interval type‐2 fuzzy logic inference system development. Tools that cover the different phases of the fuzzy system design process, from the initial description phase, to the final implementation phase, are presented as part of the Toolbox. The Toolbox's best properties are the capacity to develop complex systems and the flexibility that permits the user to extend the availability of functions for working with type‐2 fuzzy operators, linguistic variables, interval type‐2 membership functions, defuzzification methods, and the evaluation of interval type‐2 fuzzy inference systems. The toolbox can be used for educational and research purposes. © 2011 Wiley Periodicals, Inc. Comput Appl Eng Educ 21: 737–747, 2013
Academic Language in Teaching and Learning

Success in school calls for using language in new ways to accomplish increasingly challenging discursive tasks across grade levels and school subjects. As children develop new knowledge, they also need support in using language in new ways. This introduction to the special issue offers insights into the challenges and affordances of developing academic language and suggests implications for pedagogy, teacher education, and further research.
The neural basis of visual material properties in the human brain

Three independent studies with human functional magnetic resonance imaging (fMRI) measurements were designed to investigate the neural basis of visual glossiness processing in the human brain. The first study is to localize brain areas preferentially responding to glossy objects defined by specular reflectance. We found activations related to gloss in the posterior fusiform (pFs) and in area V3B/KO. The second study is to investigate how the visual-induced haptic sensation is achieved in our brain. We found that in secondary somatosensory area (S2) was distinguishable between glossy and rough surfaces, suggesting that visual information about object surfaces may be transformed into tactile information in S2. In the third study we investigate how the brain processes surface gloss information conveyed by disparity of specular reflections on stereo mirror objects and compared it with the processing of specular reflectance. We found that both dorsal and ventral areas were involving in this processing. The result implicates that in this region the processing of stereoscopic gloss information has a pattern of activation that is additional to the representation of specular reflectance. Overall, the three studies contribute to our understanding about the neural basis of visual glossiness and material processing in the human brain.
The diagnosis of borderline personality disorder: problematic but better than the alternatives.

BACKGROUND The purpose of this review is to examine empirical evidence concerning critiques of the diagnosis of borderline personality disorder (BPD): for uncertain validity, and for overlap with other mental disorders. METHODS A review of the literature on the validity and comorbidity of BPD was conducted. RESULTS Since BPD is a complex multidimensional construct, its validity is inevitably problematic, but no more so than most other psychiatric diagnoses. The comorbidity of BPD is probably an artefact of the current classification system, and there is no convincing evidence that BPD is a variant of an Axis I disorder. CONCLUSIONS Although further research should lead to changes in classification, the diagnosis of BPD retains significant clinical utility.