Miracle-dz/UniFAR-FTUs huggingface dataset:
Geographical Distribution and Prevalence Percentage of Thalassemia from Solapur, Maharashtra, India

Present study includes the geographical distribution and the prevalence of thalassemia in Solapur District, Maharashtra, India. The medical records of thalassemia patients were reviewed. Present observational survey study, one hundred twenty five clinically proved by their medical reports, cases of thalassemic children's with age 6 months to 18 Years, coming for to get blood transfusion from different parts of Solapur district. There was maximum number of 98(98.4%) cases of Thalassemia major (TM) as compared to Beta thalassemia minor (BTMi) 10(8.0%), Beta thalassemia intermedia (BTI) 16(12.8%) cases and Sickle cell thalassemia (SCT) 1(0.8%) was observed. No cases of α thalassemia were observed in our research work. INTRODUCTION The name thalassemia derived from a combination of two Greek words: thalassa meaning the sea (Cooley and Lec, 1925; Cooley, 1927; Bradford and Dye 1936), that is the Mediterranean and anemia (" weak blood "). Another term found in literature, although infrequently, is Cooley's anemia and it was believed to be endemic. Prof. Cooley Thomas (1925), a pediatrician in the USA who first described the clinical characteristics of this disorder in patients of Italian origin in 1925. Whipple and Bradford (1936) studied the erythroblastic anemia of Cooley and associated pigment anomalies simulating hemochromatosis. The profile of beta-thalassemia in eastern India and its prenatal diagnosis observed by Bandyopadhyay et al. (2004) Agarwal et al. (2003). Geographic and ethnic distribution of β-Thalassemia mutations in Uttar Pradesh was observed by Agarwal et al. (2000). Recently, in northern and western India, Nishi et al. (2008) studied the frequency of β-thalassemia trait and other hemoglobinopathies. The present study includes studying the geographical distribution and prevalence percentage of thalassemic patients from Solapur District.
A DNA methylation ratchet governs progression through a bacterial cell cycle

The Caulobacter cell cycle is driven by a cascade of transient regulators, starting with the expression of DnaA in G1 and ending with the expression of the essential CcrM DNA methyltransferase at the completion of DNA replication. The timing of DnaA accumulation was found to be regulated by the methylation state of the dnaA promoter, which in turn depends on the chromosomal position of dnaA near the origin of replication and restriction of CcrM synthesis to the end of the cell cycle. The dnaA gene is preferentially transcribed from a fully methylated promoter. DnaA initiates DNA replication and activates the transcription of the next cell-cycle regulator, GcrA. With the passage of the replication fork, the dnaA promoter becomes hemimethylated, and DnaA accumulation drops. GcrA then activates the transcription of the next cell-cycle regulator, CtrA, once the replication fork passes through the ctrA P1 promoter, generating two hemimethylated copies of ctrA. The ctrA gene is preferentially transcribed from a hemimethylated promoter. CtrA then activates the transcription of ccrM, to bring the newly replicated chromosome to the fully methylated state, promoting dnaA transcription and the start of a new cell cycle. We show that the cell-cycle timing of CcrM is critical for Caulobacter fitness. The sequential changes in the chromosomal methylation state serve to couple the progression of DNA replication to cell-cycle events regulated by the master transcriptional regulatory cascade, thus providing a ratchet mechanism for robust cell-cycle control.
Pyruvate decarboxylase: An indispensable enzyme for growth of Saccharomyces cerevisiae on glucose

In Saccharomyces cerevisiae, the structural genes PDC1, PDC5 and PDC6 each encode an active pyruvate decarboxylase. Replacement mutations in these genes were introduced in a homothallic wild‐type strain, using the dominant marker genes APT1 and Tn5ble. A pyruvate‐decarboxylase‐negative (Pdc−) mutant lacking all three PDC genes exhibited a three‐fold lower growth rate in complex medium with glucose than the isogenic wild‐type strain. Growth in batch cultures on complex and defined media with ethanol was not impaired in Pdc− strains. Furthermore, in ethanol‐limited chemostat cultures, the biomass yield of Pdc− and wild‐type S. cerevisiae were identical. However, Pdc− S. cerevisiae was unable to grow in batch cultures on a defined mineral medium with glucose as the sole carbon source. When aerobic, ethanol‐limited chemostat cultures (D = 0·10 h−1) were switched to a feed containing glucose as the sole carbon source, growth ceased after approximately 4 h and, consequently, the cultures washed out. The mutant was, however, able to grow in chemostat cultures on mixtures of glucose and small amounts of ethanol or acetate (5% on a carbon basis). No growth was observed when such cultures were used to inoculate batch cultures on glucose. Furthermore, when the mixed‐substrate cultures were switched to a feed containing glucose as the sole carbon source, wash‐out occurred. It is concluded that the mitochondrial pyruvate dehydrogenase complex cannot function as the sole source of acetyl‐CoA during growth of S. cerevisiae on glucose, neither in batch cultures nor in glucose‐limited chemostat cultures.
Face recognition based on singular valued decomposition and back progagation neural network

This paper presents a developed face recognition system. The method used singular valued decomposition as images feature extractor and back propagation neural networks as its classifier. The back propagation training parameters are varied in order to find the best parameter with the highest performance accuracy. The results from experiments have showed that combinations of both methodologies give good recognition rate and therefore considered as an effective face recognition system.
Justice, Liability, And Blame: Community Views And The Criminal Law

This book reports empirical studies on 18 different areas of substantive criminal law in which the study results showing ordinary people’s judgments of justice are compared to the governing legal doctrine to highlight points of agreement and disagreement. The book also identifies trends and patterns in these agreement and disagreement and discusses the implications for the formulation of criminal law. The chapters include: Chapter 1. Community Views and the Criminal Law (Introduction; An Overview; Why Community Views Should Matter; Research Methods) Chapter 2. Doctrines of Criminalization: What Conduct Should Be Criminal? (Objective Requirements of Attempt (Study 1); Creating a Criminal Risk (Study 2); Objective Requirements of Complicity (Study 3); Omission Liability (Study 4); Chapter Summary) Chapter 3. Doctrines of Justification: When Should It Be Lawful to Engage in Conduct That Normally Would Constitute a Violation? (Use of Deadly Force in Self-Defense (Study 5); Use of Force in Defense of Property (Study 6); Citizens' Law Enforcement Authority (Study 7); Chapter Summary) Chapter 4. Doctrines of Culpability: When Is Violation of a Legal Rule Blameworthy? (Offense Culpability Requirements and Mistake/Accident Defenses (Study 8); Culpability Requirements for Complicity (Study 9); Voluntary Intoxication (Study 10); Individualization of the Objective Standard of Negligence (Study 11); Chapter Summary) Chapter 5. Doctrines of Excuse: When Is a Rule Violation Blameless? (Insanity (Study 12); Immaturity and Involuntary Intoxication (Study 13); Duress and Entrapment Defenses (Study 14); Chapter Summary) Chapter 6. Doctrines of Grading: What Degree of Punishment Is Deserved for a Blameworthy Violation? (The Seriousness of the Offense: Sexual Offenses (Study 15); The Culpability of the Person: Felony Murder (Study 16); The Strength of the Person's Connection with the Prohibited Result: Causation Requirements (Study 17); Punishment for Multiple Offenses (Study 18); Chapter Summary) Chapter 7. Community Views and Criminal Codes Conflict (When Code and Community Agree; When Code and Community Disagree; Liability Requirements Versus Liability Factors and Dichotomous Functions Versus Continuous Functions; Criminal Liability Without Punishment; The Jury as a Resolver of Code-Community Conflicts)
Employer satisfaction, job-match and future hiring intentions for employees with a disability

This paper is based on survey responses from 656 employers who used disability employment services to employ someone with a disability. Relationships between employer satisfaction and employer perceptions of job-match and future hiring intentions toward people who have a disability are outlined and discussed. Employers' perceptions of the job-match process were found to be an important determinant of their perceptions of work performance and employer satisfaction. Comparative ratings on employer satisfaction for employees with and without a disability were seen as an important indicator of future hiring intentions toward people with a disability. Findings reported in this paper provide important information on which to base strategies for improving future employment outcomes for people who have a disability.
Conversation Analysis and Membership Categories

Membership categorization analysis (MCA) deals primarily with the way we use categories to make sense of and for each other in social interaction. As such, it is one means of explicating the practically oriented, commonsensical, and cultural reasoning of people as they go about their social lives. In particular it focuses on the recognizability of people as certain sorts of people or, more specifically, people as certain sorts of members of society, and how this recognizability is a resource for members in their dealings with each other. And as one of the primary ways in which we “deal” with each other is through language, MCA is often brought to bear on the analysis of how people use language in situations of everyday life. Keywords: discourse analysis; pragmatics; sociolinguistics
PivotViz: Interactive Visual Analysis of Multidimensional Library Transaction Data

As public libraries become increasingly digitalized they become producers of Big Data. Furthermore, public libraries are often obliged to make their data openly available as part of national open data policies, which have gained momentum in many countries including USA, UK, and Denmark. However, in order to utilize such data and make it intelligible for citizens, decision makers, or other stakeholders, raw data APIs are insufficient. Therefore, we have developed PivotViz that is a comprehensible visualization technique, which combines parallel coordinates and pivot tables. It provides, a multidimensional visual interactive pivot table for analysis of library transactions -- loans, renewals, and returns of books and other materials across location and time. The paper presents the PivotViz technique and discusses its prospects based on implementations in two publicly available versions using open data from the two largest municipalities in Denmark. Examples of analysis results from these data illustrate the power of PivotViz.
Effects of azilsartan medoxomil compared with olmesartan and valsartan on ambulatory and clinic blood pressure in patients with type 2 diabetes and prediabetes

Background: Angiotensin receptor blockers (ARBs) are preferred antihypertensive therapies in patients with type 2 diabetes mellitus (T2DM). Azilsartan medoxomil (AZL-M) is a potent ARB for the treatment of stages 1-2 hypertension. We compared the efficacy, safety, and metabolic effects of AZL-M to both valsartan (VAL) and olmesartan (OLM), separately in patients with impaired fasting glucose (prediabetes mellitus) and T2DM. Methods: A pooled analysis of 3821 patients from three separate randomized placebo-controlled trials comparing the effects of AZL-M (40 and 80 mg), OLM (40 mg), VAL (320 mg), and placebo on changes in ambulatory and clinic blood pressure (BP) among patients with hypertension and prediabetes mellitus or T2DM was performed. Two analysis pools were created to facilitate comparisons: Pool A included patients who received placebo, AZL-M or OLM and Pool B included those who received AZL-M or VAL. Within each pool, patients were stratified by glycemic subgroups (normoglycemic, prediabetes mellitus, or T2DM) based on hemoglobin A1c values. Changes from baseline in both 24-h and clinic SBP were the primary efficacy assessments. Results: Baseline 24-h mean SBPs were approximately 145 and 146 mmHg in the prediabetes mellitus and T2DM subgroups, respectively; corresponding clinic SBPs were approximately 158 and 159 mmHg. Baseline hemoglobin A1c values for each subgroup (both pools) were normoglycemic, 5.3%; prediabetes mellitus, 6.0%; and T2DM, 6.9%. Changes from baseline in 24-h or clinic SBP were significantly greater with AZL-M, 80 mg compared with either OLM 40 mg or VAL 320 mg in all subgroups in each pool. Safety and tolerability were similar among the active treatment and placebo subgroups. Conclusion: These analyses indicate that AZL-M, 80 mg/day lowers SBP by a greater magnitude than OLM or VAL at maximally approved doses in patients with prediabetes mellitus and T2DM. These findings have important clinical implications for this high-risk patient group.
Dense Approximate Storage in Phase-Change Memory

Multi-level phase-change memory stores bits by quantizing the resistance value of each cell. For example, a PCM cell with four distinct resistance levels can store two bits. By dramatically increasing this granularity, high density can be achieved at the cost of storage reliability. Many applications—those that deal with sensory data or are otherwise resilient to errors—can take advantage of this increased density with only small impact on overall quality of service. We present a very basic evaluation that suggests that approximate PCM storage may be a good option for lossy image storage.
Sequential Effects in Essay Ratings

Contrary to previous research on sequential ratings of student performance, this study found that professional essay raters of a large-scale standardized testing program produced ratings that were drawn toward previous ratings, creating an assimilation effect. Longer intervals between the two adjacent ratings and higher degree of agreement with other raters were associated with smaller assimilation effects. The effect was also found to create a small bias in favor of low-achieving groups of examinees.
COMPARACIÓN DE LOS PROCESOS DE MOVILIZACIÓN CORPORAL DE LOS ALUMNOS EN DOS NIVELES ESCOLARES

Resumen: En Mexico la educacion basica se integra por 3 niveles: Preescolar, Primaria y Secundaria, cada uno se imparte en planteles diferentes. Los alumnos que egresan de primaria tienen regularmente entre 12-13 anos, es una edad de profundos cambios a los que se agregan el cambio de plantel escolar, el cambio de companeros de aula y una mayor especializacion en la organizacion y las estrategias de trabajo en las escuelas, que tiene como consecuencia un mayor numero de profesores. En la secundaria las estructuras institucionales son mas duras y el control disciplinario es mayor, por lo que los estudiantes buscan nuevas maneras de negociar. Este articulo trata de esas vivencias, de como el control sobre la apariencia, la ubicacion y los movimientos del cuerpo impacta a los alumnos por medio de los portavoces y las normas y de como el control del cuerpo se ‘hace parte’ del trabajo escolar cotidiano. Se utiliza un enfoque etnografico enriquecido por las categorias de la teoria del actor-red (ANT) lo que permite visualizar el paso de los alumnos de un nivel a otro como una red de trayectorias e itinerarios en tension que trasciende las escalas del espacio y el tiempo medido. Se asume que los estudiantes con su accion tambien construyen el contexto. Palabras clave: Cuerpo - Movilizacion - Trayectorias - Estudiantes - Educacion Basica Abstract: In Mexico, basic schooling is composed of three levels: infant (or preschool) education, primary (or elementary) education and secondary (or middle school) education, each taught at a different educational establishment. Students egressing from elementary school are (in average) between 12 to 13 years-old, an age of profound changes to which the following can be added: a different educational establishment, different class mates/peers, higher organizational specialization and class work strategies which, in turn, result in a higher number of teachers. Secondary schools have harder institutional structures and higher disciplinary control, so that students seek new ways of negotiation. This article elaborates on those experiences, on how control over appearance, place and body movements influences students through spokesmen and norms, and how body control effectively 'becomes part' of daily class work. I use an ethnographic approach enriched by the categories of Actor-Network Theory (ANT), which allows visualization of the passage of students from one level to another as a network of paths and routes in tension transcending space scales and measured time. It is assumed that students will also build its action context. Keywords: Body - Mobilization - Trajectories - Students - Basic Education
Brightness-Temperature Retrieval Methods in Synthetic Aperture Radiometers

Brightness-temperature retrieval techniques for synthetic aperture radiometers are reviewed. Three different approaches to combine measured visibility and antenna temperatures, along with instrument characterization data, into a general equation to invert are presented. Discretization and windowing techniques are briefly discussed, and formulas for reciprocal grids using rectangular and hexagonal samplings are given. Two known techniques are used to invert the equation, namely, inverse Fourier transform and G -matrix pseudoinverse. The proposed preprocessing approaches combined with these two inversion methods are implemented with real data measured by an airborne Y-shaped interferometric radiometer over land and water, and are compared. The images indicate that best results are obtained when inverting an incremental visibility obtained after substracting a term that includes the individual antenna temperatures, the physical temperatures of the receivers, and a flat-target response directly measured from cold-sky looks.
Augmenting Successful UK Healthcare IS Adoption and Diffusion: An Analysis of Inherent and Emergent Organizational Structures

The evidence suggests that information systems (IS) continue to be designed, adopted and diffused within public sector organisations to support the ‘reform’ agendas of national governments with a particular emphasis upon improving the accessibility and transparency of services. It is argued that Actor-Network Theory (ANT) provides useful theoretical insights into how stakeholders are able to organise in this respect. This is to highlight structures where non-human actors adopt a mechanism to examine advanced technologies (inherent structures), and structures that actually emerge as human actions engage with the context, ie healthcare IS adoption and diffusion processes. The research in this paper is based on a qualitative approach analyzing data collected from more than hundred respondents in the UK National Health Service (NHS). An attempt is made to illustrate that technology is just one of a number of heterogeneous sociotechnical elements that must be managed within a successful information systems project. The paper concludes by offering ideas and directions for future research in the health sector using ANT analysis.
A recurrent self-organizing neural fuzzy inference network

A recurrent self-organizing neural fuzzy inference network (RSONFIN) is proposed in this paper. The RSONFIN is inherently a recurrent multilayered connectionist network for realizing the basic elements and functions of dynamic fuzzy inference, and may be considered to be constructed from a series of dynamic fuzzy rules. The temporal relations embedded in the network are built by adding some feedback connections representing the memory elements to a feedforward neural fuzzy network. Each weight as well as node in the RSONFIN has its own meaning and represents a special element in a fuzzy rule. There are no hidden nodes (i.e., no membership functions and fuzzy rules) initially in the RSONFIN. They are created on-line via concurrent structure identification (the construction of dynamic fuzzy if-then rules) and parameter identification (the tuning of the free parameters of membership functions). The structure learning together with the parameter learning forms a fast learning algorithm for building a small, yet powerful, dynamic neural fuzzy network. Two major characteristics of the RSONFIN can thus be seen: 1) the recurrent property of the RSONFIN makes it suitable for dealing with temporal problems and 2) no predetermination, like the number of hidden nodes, must be given, since the RSONFIN can find its optimal structure and parameters automatically and quickly. Moreover, to reduce the number of fuzzy rules generated, a flexible input partition method, the aligned clustering-based algorithm, is proposed. Various simulations on temporal problems are done and performance comparisons with some existing recurrent networks are also made. Efficiency of the RSONFIN is verified from these results.
Fulfillment as Sanders' Sixth Phase of Bereavement: The Unfinished Work of Catherine Sanders

Prior to her death, Catherine Sanders was interested in modifying her earlier work on the phases of grief. She had begun to explore the conceptualization of a sixth phase of the grieving process that she tentatively termed fulfillment. This conceptualization not only reflected her research but her own personal grief journey. This article both presents Sanders' early theorizing about this phase and places it in the context of her life and her life's work.
THE TREYNOR CAPITAL ASSET PRICING MODEL 61 empirical research

History generally accords the development of the single-period, discrete-time Capital Asset Pricing Model (CAPM) to the works of Sharpe (1964), Lintner (1965a,b) and Mossin (1966). We explore the early work of another notable financial economist, Jack L. Treynor, who also deserves credit for the original Capital Asset Pricing Model because of his revolutionary manuscripts—“Market Value, Time, and Risk”, Treynor (1961), and “Toward a Theory of Market Value of Risky Assets”, Treynor (1962)—which were circulated during the 1960s in mimeographed draft form but have never been published in an academic or practitioner journal. Mr. Treynor’s early work appears to have predated and anticipated Sharpe (1964), Lintner (1965a,b) and Mossin (1966). However, while financial economists initially credited Mr. Treynor for his innovation, the Treynor CAPM has not enjoyed a broad public reach. This, apparently, is the reason Mr. Treynor is not consistently recognized as one of the primary architects of the CAPM.