Miracle-dz/UniFAR-FTUs huggingface dataset:
Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and therapeutic possibilities

Human tissues express cannabinoid CB1 and CB2 receptors that can be activated by endogenously released ‘endocannabinoids’ or exogenously administered compounds in a manner that reduces the symptoms or opposes the underlying causes of several disorders in need of effective therapy. Three medicines that activate cannabinoid CB1/CB2 receptors are now in the clinic: Cesamet (nabilone), Marinol (dronabinol; Δ9-tetrahydrocannabinol (Δ9-THC)) and Sativex (Δ9-THC with cannabidiol). These can be prescribed for the amelioration of chemotherapy-induced nausea and vomiting (Cesamet and Marinol), stimulation of appetite (Marinol) and symptomatic relief of cancer pain and/or management of neuropathic pain and spasticity in adults with multiple sclerosis (Sativex). This review mentions several possible additional therapeutic targets for cannabinoid receptor agonists. These include other kinds of pain, epilepsy, anxiety, depression, Parkinson's and Huntington's diseases, amyotrophic lateral sclerosis, stroke, cancer, drug dependence, glaucoma, autoimmune uveitis, osteoporosis, sepsis, and hepatic, renal, intestinal and cardiovascular disorders. It also describes potential strategies for improving the efficacy and/or benefit-to-risk ratio of these agonists in the clinic. These are strategies that involve (i) targeting cannabinoid receptors located outside the blood-brain barrier, (ii) targeting cannabinoid receptors expressed by a particular tissue, (iii) targeting upregulated cannabinoid receptors, (iv) selectively targeting cannabinoid CB2 receptors, and/or (v) adjunctive ‘multi-targeting’.
Measuring the Practical Impact of DNSSEC Deployment

DNSSEC extends DNS with a public-key infrastructure, providing compatible clients with cryptographic assurance for DNS records they obtain, even in the presence of an active network attacker. As with many Internet protocol deployments, administrators deciding whether to deploy DNSSEC for their DNS zones must perform cost/benefit analysis. For some fraction of clients--those that perform DNSSEC validation--the zone will be protected from malicious hijacking. But another fraction of clients--those whose DNS resolvers are buggy and incompatible with DNSSEC--will no longer be able to connect to the zone. Deploying DNSSEC requires making a cost-benefit decision, balancing security for some users with denial of service for others. We have performed a large-scale measurement of the effects of DNSSEC on client name resolution using an ad network to collect results from over 500,000 geographically-distributed clients. Our findings corroborate those of previous researchers in showing that a relatively small fraction of users are protected by DNSSEC-validating resolvers. And we show, for the first time, that enabling DNSSEC measurably increases end-to-end resolution failures. For every 10 clients that are protected from DNS tampering when a domain deploys DNSSEC, approximately one ordinary client (primarily in Asia) becomes unable to access the domain.
Progress and future directions for atomic layer deposition and ALD-based chemistry

This article reviews and assesses recent progress in atomic layer deposition (ALD) and highlights how the field of ALD is expanding into new applications and inspiring new vapor-based chemical reaction methods. ALD is a unique chemical process that yields ultra-thin film coatings with exceptional conformality on highly non-uniform and non-planar surfaces, often with subnanometer scale control of the coating thickness. While industry uses ALD for high-κ dielectrics in the manufacturing of electronic devices, there is growing interest in low-temperature ALD and ALD-inspired processes for newer and more wide-ranging applications, including integration with biological and synthetic polymer structures. Moreover, the conformality and nanoscale control of ALD film thickness makes ALD ideal for encapsulation and nano-architectural engineering. Articles in this issue of MRS Bulletin present details of several growing interest areas, including the extension of ALD to new regions of the periodic table, and molecular layer deposition and vapor infiltration for synthesis of organic-based thin films. Articles also discuss ALD for nanostructure engineering and ALD for energy applications. A final article shows how the challenge of scaling ALD for high rate nanomanufacturing will push advances in plasma, roll-to-roll, and atmospheric pressure ALD.
Monolithic Capacitive DC-DC Converter With Single Boundary–Multiphase Control and Voltage Domain Stacking in 90 nm CMOS

Monolithic integration in CMOS has boosted the development of low cost, compact and portable consumer applications. But until now the monolithic integration of DC-DC converters is still omitted in commercial applications. Primarily due to the need for high-efficiency converters and appropriate techniques to control high-frequency capacitive DC-DC converters. This paper presents a fully integrated capacitive step-down DC-DC converter in 90 nm CMOS with an output power capability of 150 mW, a peak efficiency of 77% and a full load efficiency of 74%. The DC-DC converter is controlled by a Single Boundary-Multiphase Control (SB-MC). This control method provides a low power solution for controlling multiphase capacitive DC-DC converters without compromising the control loop bandwidth. This paper describes the design, implementation and measurements of the DC-DC converter.
Effect of Age on Arterial Distensibility in Asymptomatic Humans

This report describes a noninvasive method by which the volume distensibility of forearm arteries can be calculated from direct measurements of pulse wave velocity. Such measurements are made at a variety of transmural arterial pressures (TMP) accomplished by placing the forearm in a cylinder and changing the pressures within. This technique eliminates arterial blood pressure as a variable, which strongly influences arterial distensibility. We studied 48 asymptomatic men and women, ages 21 to 98 years. There was considerable scatter, but significant positive relationships were demonstrated between increasing arterial distensibility and age at ambient and lower TMPs. This finding can be explained by an age-related reduction in arterial luminal diameter and an increase in arterial wall thickness which reduces arterial wall tension and more than offsets the increased stiffness produced by changes in wall composition. In six subjects, pulse tracings were simultaneously recorded on paper and analog tape. The taped curves were digitized and subjected to Fourier analysis to determine the wave velocity of individual harmonics. The characteristic wave velocity was defined and found comparable to the hand method used in the same beats (regression coefficient = + 0.97). These data indicate that the automatic and manual methods measured the same variable.
Qualitative Evaluation of Automatically Calculated Acception Based MLDB

In the context of the Papillon project, which aims at creating a multilingual lexical database (MLDB), we have developed Jeminie, an adaptable system that helps automatically building interlingual lexical databases from existing lexical resources. In this article, we present a taxonomy of criteria for evaluating a MLDB, that motivates the need for arbitrary compositions of criteria to evaluate a whole MLDB. A quality measurement method is proposed, that is adaptable to different contexts and available lexical resources.
Imaging appearance of the symptomatic perforating artery in patients with lacunar infarction: Occlusion or other vascular pathology?

Lacunar infarction is associated with distinct clinical features. It is thought to result from occlusion of a deep perforating artery in the basal ganglia, centrum semiovale, or brainstem. However, occluded perforating arteries have only rarely been observed at postmortem in patients with lacunar stroke and have not been noted previously on imaging despite the increasing sophistication of the techniques. We observed nine patients with lacunar stroke imaged with computed tomography and magnetic resonance imaging in whom we observed a linear structure with density or signal features consistent with an occluded (or at least abnormal) perforating artery associated with the relevant lacunar infarct. The appearance might also have been caused by a leak of blood and fluid into the perivascular space around the artery, as in several patients the width of the tubular vessel‐like structure (>1mm in diameter) was greater than the expected width of a perforating artery (<0.8mm in diameter). This interpretation is supported by the fact that the area of infarction was usually around the abnormal vessel, not at the end of it. We describe the patients' clinical and imaging features, and discuss alternative explanations for the imaging appearance and the implications for gaining insights into the cause of lacunar infarction.
Can Exercise Training With Weight Loss Lower Serum C-Reactive Protein Levels?

Objective—C-reactive protein (CRP), an obesity-related inflammatory marker, is a promising predictor for cardiovascular disease and may be a mediator for atherogenesis. It has been reported that diet-induced weight loss lowered CRP levels. However, the effect of exercise training, another therapy that can reduce weight, on CRP is still unclear. We examined effects of exercise training with weight loss on CRP levels and conventional cardiovascular risks. Methods and Results—A total of 227 apparently healthy women were recruited, and 199 subjects (average age 52 years) completed a 2-month weight reduction program consisting of supervised aerobic exercises. After the program, weight was reduced from 65.8 to 62.8 kg (P<0.0001), and all conventional variables were remarkably improved. Similarly, CRP levels were significantly decreased, from 0.63 (0.28 to 1.19) to 0.41 (0.18 to 0.80) mg/L (P<0.0001). However, in contrast to other variables, the changes in CRP levels were not proportionally associated with the extent of weight reduction. In the quartile analysis of % weight reduction, the largest weight reduction quartile did not show significant decreases in CRP levels, whereas moderate quartile showed remarkable CRP decreases. Conclusions—Exercise training with weight reduction disproportionately lowered CRP levels. Considering inflammatory status, there might be an optimal pace of exercise with weight loss.
Enhanced Detection of Paroxysmal Atrial Fibrillation by Early and Prolonged Continuous Holter Monitoring in Patients With Cerebral Ischemia Presenting in Sinus Rhythm

Background and Purpose Diagnosis of paroxysmal atrial fibrillation is difficult but highly relevant in patients presenting with cerebral ischemia yet free from atrial fibrillation on admission. Early initiation and prolongation of continuous Holter monitoring may improve diagnostic yield compared with the standard of care including a 24-hour Holter recording. Methods— In the observational Find-AF trial (ISRCTN 46104198), consecutive patients presenting with symptoms of cerebral ischemia were included. Patients free from atrial fibrillation at presentation received 7-day Holter monitoring. Results— Two hundred eighty-one patients were prospectively included. Forty-four (15.7%) had atrial fibrillation documented by routine electrocardiogram on admission. All remaining patients received Holter monitors at a median of 5.5 hours after presentation. In those 224 patients who received Holter monitors but had no previously known paroxysmal atrial fibrillation, the detection rate with early and prolonged (7 days) Holter monitoring (12.5%) was significantly higher than for any 24-hour (mean of 7 intervals: 4.8%, P=0.015) or any 48-hour monitoring interval (mean of 6 intervals: 6.4%, P=0.023). Of those 28 patients with new atrial fibrillation on Holter monitoring, 15 (6.7%) had been discharged without therapeutic anticoagulation after routine clinical care (ie, with data from 24-hour Holter monitoring only). Detection rates were 43.8% or 6.3% for short supraventricular runs of ≥10 beats or prolonged episodes (<5 hours) of atrial fibrillation, respectively. Diagnostic yield appeared to be only slightly and not significantly increased during the first 3 days after the index event. Conclusions— Prolongation of Holter monitoring in patients with symptoms of cerebral ischemic events increases the rate of detection of paroxysmal atrial fibrillation up to Day 7, leading to a relevant change in therapy in a substantial number of patients. Early initiation of monitoring does not appear to be crucial. Hence, prolonged Holter monitoring (≥7 days) should be considered for all patients with unexplained cerebral ischemia.
Highly Active Antiretroviral Therapy Alters Sperm Parameters and Testicular Antioxidant Status in Diet-Induced Obese Rats

The efficacy of highly active antiretroviral therapy (HAART) has led to an increase demand for therapeutic use, thereby necessitating investigation into drug toxicity. This study was designed to investigate the in vivo effects of HAART on sperm parameters and testicular oxidative stress in lean and obese rats. Wistar rats (males, n = 40, weighing 180∼200 g) were assigned randomly into 4 groups and treated accordingly for 16 weeks as follows: Control (C): lean group fed with standard rat chow; Diet induced obesity (DIO): obese animals fed a high caloric diet; C + ART: lean animals treated with HAART; DIO + ART: obese animals treated with HAART. An antiretroviral drug combination of Tenofovir, Emtricitabine and Efavirenz at a dose of 17, 26 and 50 mg/kg/day was administered for the latter 6 weeks via jelly cube feeding. At the end of the experimental period, sperm analysis was performed on sperm collected from the caudal epididymis, while the testis was homogenized for antioxidant enzyme and lipid peroxidation assays. Results showed that HAART significantly decreased sperm motility ( p < 0.05) in both lean and obese animals, and viability ( p < 0.05) in the DIO group. Testicular glutathione, catalase and superoxide dismutase were significantly decreased ( p < 0.05), while Thiobarbituric acid reactive substances (TBARS) levels were significantly increased ( p < 0.05) when the DIO+ART group was compared to Control group. Thus, the decreased sperm qualities associated with HAART might be as a result of increased testicular oxidative stress prominent in obese animals.
Disturbance and the Dynamics of Coral Cover on the Great Barrier Reef (1995–2009)

Coral reef ecosystems worldwide are under pressure from chronic and acute stressors that threaten their continued existence. Most obvious among changes to reefs is loss of hard coral cover, but a precise multi-scale estimate of coral cover dynamics for the Great Barrier Reef (GBR) is currently lacking. Monitoring data collected annually from fixed sites at 47 reefs across 1300 km of the GBR indicate that overall regional coral cover was stable (averaging 29% and ranging from 23% to 33% cover across years) with no net decline between 1995 and 2009. Subregional trends (10–100 km) in hard coral were diverse with some being very dynamic and others changing little. Coral cover increased in six subregions and decreased in seven subregions. Persistent decline of corals occurred in one subregion for hard coral and Acroporidae and in four subregions in non-Acroporidae families. Change in Acroporidae accounted for 68% of change in hard coral. Crown-of-thorns starfish (Acanthaster planci) outbreaks and storm damage were responsible for more coral loss during this period than either bleaching or disease despite two mass bleaching events and an increase in the incidence of coral disease. While the limited data for the GBR prior to the 1980's suggests that coral cover was higher than in our survey, we found no evidence of consistent, system-wide decline in coral cover since 1995. Instead, fluctuations in coral cover at subregional scales (10–100 km), driven mostly by changes in fast-growing Acroporidae, occurred as a result of localized disturbance events and subsequent recovery.
Parainfluenza Virus 5 M Protein Interaction with Host Protein 14-3-3 Negatively Affects Virus Particle Formation

ABSTRACT Paramyxovirus matrix (M) proteins organize virus assembly, linking viral glycoproteins and viral ribonucleoproteins together at virus assembly sites on cellular membranes. Using a yeast two-hybrid screening approach, we identified 14-3-3 as a binding partner for the M protein of parainfluenza virus 5 (PIV5). Binding in both transfected and PIV5-infected cells was confirmed by coimmunoprecipitation and was mapped to a C-terminal region within the M protein, namely, 366-KTKSLP-371. This sequence resembles known 14-3-3 binding sites, in which the key residue for binding is a phosphorylated serine residue. Mutation of S369 within the PIV5 M protein disrupted 14-3-3 binding and improved the budding of both virus-like particles (VLPs) and recombinant viruses, suggesting that 14-3-3 binding impairs virus budding. 14-3-3 protein overexpression reduced the budding of VLPs. Using 33P labeling, phosphorylated M protein was detected in PIV5-infected cells, and this phosphorylation was nearly absent in cells infected with a recombinant virus harboring an S369A mutation within the M protein. Assembly of the M protein into clusters and filaments at infected cell surfaces was enhanced in cells infected with a recombinant virus defective in 14-3-3 binding. These findings support a model in which a portion of M protein within PIV5-infected cells is phosphorylated at residue S369, binds the 14-3-3 protein, and is held away from sites of virus budding.
Experimental Evaluation of Emerging Multi-core Architectures

The trend of increasing speed and complexity in the single-core processor as stated in the Moore's law is facing practical challenges. As a result, the multi-core processor architecture has emerged as the dominant architecture for both desktop and high-performance systems. Multi-core systems introduce many challenges that need to be addressed to achieve the best performance. Therefore, a new set of benchmarking techniques to study the impacts of the multi-core technologies is necessary. In this paper, multi-core specific performance metrics for cache coherency and memory bandwidth/latency/contention are investigated. This study also proposes a new benchmarking suite which includes cases extended from the high performance computing challenge (HPCC) benchmark suite. Performance results are measured on a Sun Fire T1000 server with six cores and an AMD Opteron dual core system. Experimental analysis and observations in this paper provide for a better understanding of the emerging multi-core architectures.
Achieving Enhanced Fracture Toughness of Adhesively Bonded Cured Composite Joint Systems Using Atmospheric Pressure Plasma Treatments

Fibre reinforced composite materials are widely used in products ranging from automobile bumpers to aircraft wings and sports equipment. The objective of this research was to compare the performance of both helium / oxygen and air atmospheric plasma treatment systems for enhancing the bond strength between the composite materials and adhesive layer. The atmospheric plasma systems investigated were a reel-to-reel helium plasma system called Labline and an air jet system called PlasmaTreat. The plasma in the case of the former system is formed using a helium / oxygen gas mixture, while the PlasmaTreat system uses an air plasma. The research investigated the effectiveness of these two atmospheric plasma sources at activating cured composite surfaces, their effect on surface chemistry, in addition to the fracture toughness and failure mechanism of treated and adhesively bonded cured composite joints. The level of surface activation was examined using water contact angle measurements. Surface hydrophobic recovery of the treated composites was monitored over a period of 12 days. Surface chemistry was examined using X-ray photoelectron spectroscopy (XPS). The failure mechanism of the adhesively bonded composite joints was studied by double cantilever beam (DCB) tests. It was observed that for both plasma treatment systems the locus of failure changed from interfacial between composite and adhesive layer to either cohesive or interlaminar in the composite, depending on the adhesive employed. The more intense PlasmaTreat air plasma was found to significantly reduce composite treatment times and the treated surfaces exhibited reduced levels of hydrophobic recovery compared with that obtained with the Labline system.
Estimating Maximum Confidence and Trustworthiness for Facts for Information Providers on the Web

--Web mining is the application of data mining techniques to discover patterns from the Web according to analysis targets. Data quality is the quality of data of high quality "if they are fit for their intended uses in operations, decision making and planning” or refers to the degree of excellence exhibited by the data in relation to the portrayal of the actual phenomena. Keywords--Data quality, Link analysis, Web mining, Page rank.
The Radial Velocity Measurement and Error Analysis for Low Resolution Spectra

Radial velocity error of the spectra always be given by the widths of the cross-correlation function of the target spectrum and template spectrum. Radial velocity error affected by many inevitable factors, caused by instrument, observation weather, etc. Another important error comes from calibration, which should be reduced as much as possible. This paper analysis the error based on different temperatures for different types of spectral. The effect of the calibration error to the radial velocity error is also presented.
Topology discovery by active probing

As the Internet has grown, so has the challenge of accurate measurement and modeling of its topology. Commonly used but coarse methods of measuring topology, e.g., BGP tables, suffer from several limitations. To pursue more accurate empirically-based topology modeling, in 1998 CAIDA began its Macroscopic Topology Project, which focuses on actively measuring topology and round trip time (RTT) information across a large cross-section of the commodity Internet. We describe CAIDA's topology measurement architecture and our analysis and visualization tools. We describe differences between IP and AS (BGP-based) granularities of topology modeling, including advantages and limitations of both, as well as how correlation between both types of data can yield more relevant insights. We introduce four new visualization metaphors for handling macroscopic topology data, as well as a tool for aggregating multiple IP addresses into the same physical router. We highlight results of our analyses, in particular relationships between RTT and topology data, and how source and destination selection and geopolitical boundaries affect those relationships.
Predicting protein–protein interactions based only on sequences information

Protein–protein interactions (PPIs) are central to most biological processes. Although efforts have been devoted to the development of methodology for predicting PPIs and protein interaction networks, the application of most existing methods is limited because they need information about protein homology or the interaction marks of the protein partners. In the present work, we propose a method for PPI prediction using only the information of protein sequences. This method was developed based on a learning algorithm-support vector machine combined with a kernel function and a conjoint triad feature for describing amino acids. More than 16,000 diverse PPI pairs were used to construct the universal model. The prediction ability of our approach is better than that of other sequence-based PPI prediction methods because it is able to predict PPI networks. Different types of PPI networks have been effectively mapped with our method, suggesting that, even with only sequence information, this method could be applied to the exploration of networks for any newly discovered protein with unknown biological relativity. In addition, such supplementary experimental information can enhance the prediction ability of the method.