Miracle-dz/UniFAR-FTUs huggingface dataset:
A comprehensive approach for computation and implementation of efficient electricity transmission network charges

— This paper presents a comprehensive design of electricity transmission charges that are meant to recover regulated network costs. In addition, these charges must be able to meet a set of inter-related objectives. Most importantly, they should encourage potential network users to internalize transmission costs in their location decisions, while interfering as least as possible with the short-term behaviour of the agents in the power system, since this should be left to regulatory instruments in the operation time range. The paper also addresses all those implementation issues that are essential for the sound design of a system of transmission network charges: stability and predictability of the charges; fair and efficient split between generation and demand charges; temporary measures to account for the low loading of most new lines; number and definition of the scenarios to be employed for the calculation and format of the final charges to be adopted: capacity, energy or per customer charges. The application of the proposed method is illustrated with a realistic numerical example that is based on a single scenario of the 2006 winter peak in the Spanish power system.
Testing the Goodness of Supplementary Feeding to Enhance Population Viability in an Endangered Vulture

Background Human-predator conflicts are directly or indirectly threatening many species with extinction. Thus, biologists are urged to find simple solutions to complex situations while avoiding unforeseen conservation outcomes. The provision of supplementary food at artificial feeding sites (AFS) is frequently used in the conservation of scavenger bird populations currently suffering from indirect poisoning, although no scientific studies on its effectiveness have been conducted. Methodology/Principal Findings We used a long-term data set of 95 individually marked birds from the largest European core of the endangered bearded vulture (Gypaetus barbatus) to test the long-term effects of specific AFS for bearded vultures on their survival rates (by CMR models) and population dynamics (by Monte Carlo simulations) in an area where fatalities derived from illegal poisoning and the use of other toxics like veterinary drugs have increased over the last several years. Our data support the positive relationship between the use of AFS and survival. However, contrary to theoretical predictions (e.g. high and more stable adult survival among long-lived species), the use of AFS increased only survival of pre-adults. Moreover, AFS buffered the effects of illegal poisoning on this age-class, while adult survival decreased over years. Our simulations predicted a maximum value of extinction probability over a time horizon of 50 years. Population projections run with survival rates expected in scenarios without poisoning predicted the situation of least conservation concern, while including only AFS can maintain a large floater surplus that may delay population decline but fails to reduce poisoning risk among adults. Conclusions/Significance Although AFS are not effective to save bearded vultures from an expected population decline, they delay population extinction and can be a useful tool for prolonging population viability while combating illegal and indirect poisoning. The eradication of different sources of poisoning is of top priority to ensure the long-term viability of this and many other species.
Design and evaluation of elastic media resource allocation algorithms using CloudSim extensions

With the maturity of Cloud computing comes research into converting a range of traditionally best effort programs into cloud-enabled services. One such service currently under investigation in the Elastic Media Distribution (EMD) project, is how to enable qualitative, reliable and scalable realtime media collaboration services using proven Cloud technology. While existing best-effort solutions provide plenty of features, they do not provide the quality guarantees and reliability required for critical services in globally distributed corporations. On the other hand, some pricey dedicated solutions do offer these low-delay, reliable cooperation services, but without the benefits that clouds can bring in terms of scalability. In this paper we describe results attained in the EMD project on novel resource provisioning algorithms for a mixture of end-to-end Audio/Video streams with file-based transfers, allowing for configurable tradeoffs between service response time and cost. We extended the CloudSim simulator with models allowing us to simulate collaborative interactive sessions (more specifically educational real-time collaboration), and evaluated the performance of our proposed provisioning heuristics. The results show that the proposed dynamic algorithm allows for automated cost-performance tradeoff by reducing average total Virtual Machine (VM) cost by a maximum of 58% compared to more naive approaches, while keeping average time for clients to join a meeting in line.
Obfuscating Keystroke Time Intervals to Avoid Identification and Impersonation

There are numerous opportunities for adversaries to observe user behavior remotely on the web. Additionally, keystroke biometric algorithms have advanced to the point where user identification and soft biometric trait recognition rates are commercially viable. This presents a privacy concern because masking spatial information, such as IP address, is not sufficient as users become more identifiable by their behavior. In this work, the well-known Chaum mix is generalized to a scenario in which users are separated by both space and time with the goal of preventing an observing adversary from identifying or impersonating the user. The criteria of a behavior obfuscation strategy are defined and two strategies are introduced for obfuscating typing behavior. Experimental results are obtained using publicly available keystroke data for three different types of input, including short fixed-text, long fixed-text, and long free-text. Identification accuracy is reduced by 20% with a 25 ms random keystroke delay not noticeable to the user.
Functional organization in the ferret visual cortex: a double-label 2- deoxyglucose study

The functional organization of visual cortical area 17/18 of the ferret was studied using a double-label 2-deoxyglucose (2-DG) method. Animals were stimulated sequentially with moving gratings of 2 different orientations. Elongated orientational patches running roughly at a right angle into the area 17/18 border were seen. The orientation maps were similar in areas 17 and 18. When animals were stimulated with 2 orthogonally oriented gratings, activation patterns were not fully complementary but did not overlap. A complex pattern of partial overlap was observed, with orientations differing by 45 degrees. More gradual and more abrupt changes alternated frequently on a scale smaller than the average periodicity in the patterns. A cortical patch representing a given orientation was regularly surrounded by both neighboring and orthogonal orientations. The direction of the orientational changes reversed frequently in the immediate vicinity of any orientational patch. Orientation maps were compared with complete maps of retino- cortical projections obtained by transneuronal labeling with intravitreally injected tritiated proline. Ocular dominance in the binocular segment of both areas 17 and 18 was found to be organized into elongated ipsilateral islands in an almost contiguous contralateral projection. In area 18, the patches were wider than in area 17, and the ipsilateral islands were smaller in the regions representing the upper and central visual field than in those representing the lower visual field.
A Focused, Context-Sensitive Approach to Monitoring

We address two issues which arise in the task of detecting anomalous behavior in complex systems with numerous sensor channels: how to adjust alarm thresholds dynamically, within the changing operating context of the system, and how to utilize sensors selectively, so that nominal operation can be verified reliably without processing a prohibitive amount of sensor data. Our approach involves simulation of a causal model of the system, which provides information on expected sensor values, and on dependencies between predicted events, useful in assessing the relative importance of events so that sensor resources can be allocated effectively. 1. The Monitoring Problem Timely detection of anomalous behavior is essential for the continuous safe operation and longevity of aerospace systems. The pilot of a jet aircraft must be aware of any conditions which may affect thrust during the critical moments of takeoff. The thermal environment onboard Space Station Freedom must be carefully controlled to provide uninterrupted life support for the crew. The Mars Rover must react quickly to an unpredictable environment or the mission may come to an abrupt conclu-
On aligning techniques, feature extraction and distance measures for Isolated Word Recognition

Discrete Hidden Markov Models (DHMM's) are used in Automatic Speech Recognition (ASR) systems to model the dynamics of utterances as stochastic processes. Some researchers however prefer the use of Dynamic Time Warping (DTW) to deal with variations on the temporal evolution of utterances of the same word. Furthermore, some researchers in the field of ASR recommend the use of Mel frequency Cepstral Coefficients (MFCC) as the relevant features to be extracted from the speech signal while others use Linear Prediction Coefficients (LPC) for that matter. At evaluating the similarity of feature vectors we may use euclidean distance, cosine distance or the Itakura distance (in case of using LPC). We would like to know what combination of techniques should ASR developers use in the specific problem of Isolated Word Recognition. We implemented a number of ASR systems by changing the feature extraction module, the aligning techinque, the distance measure, or parameter's values and compared them in order for the sake of those interested in developping Isolated Word recognition systems. In this paper we report the results of our experiments using Receiver Operating Characteristics (ROC) curves to show which ASR system achieved the highest recognition rate.
Enzymology of RNA cap synthesis

The 5′ guanine‐N7 methyl cap is unique to cellular and viral messenger RNA (mRNA) and is the first co‐transcriptional modification of mRNA. The mRNA cap plays a pivotal role in mRNA biogenesis and stability, and is essential for efficient splicing, mRNA export, and translation. Capping occurs by a series of three enzymatic reactions that results in formation of N7‐methyl guanosine linked through a 5′‐5′ inverted triphosphate bridge to the first nucleotide of a nascent transcript. Capping of cellular mRNA occurs co‐transcriptionally and in vivo requires that the capping apparatus be physically associated with the RNA polymerase II elongation complex. Certain capped mRNAs undergo further methylation to generate distinct cap structures. Although mRNA capping is conserved among viruses and eukaryotes, some viruses have adopted strategies for capping mRNA that are distinct from the cellular mRNA capping pathway. Copyright © 2010 John Wiley & Sons, Ltd.
Attention level approximation of a conversation in human-robot vocal interaction using prosodic features of speech

With the widespread use of robots and integration of robots into the daily human life, the communication abilities of the robots are highlighted in order to ensure smooth interaction. Domestic robots with conversation capabilities are getting an increasing demand due to the fact that modern lifestyles are driving elderly community into isolation. One of the requirements of a conversation system is to ensure that all the people involved are interested in carrying out the conversation. Humans use various physical parameters in order to determine the interest level of the speaker to ensure the conversation is interesting for both parties. The interest level estimation can be used by the robot as a form of feedback to evaluate the effectiveness of the conversation system. In order to evaluate the attention level of the user a system using the prosodic features of speech is proposed. Prosodic features can be associated with the auditory and acoustic measures. These features are important in indicating emotions and attitudes of the speaker. By using the proposed system the robot will be able to determine the interest level using the responses given by the user to the robot by analyzing the prosodic parameters of the vocal response.
Lipid Storage Metabolism Is Limited by the Prevailing Low Oxygen Concentrations within Developing Seeds of Oilseed Rape1

The aim of this study was to investigate whether endogenous restrictions in oxygen supply are limiting for storage metabolism in developing oilseed rape (Brassica napus) seeds. Siliques were studied 30 d after flowering, when rapid lipid accumulation is occurring in the seeds. (a) By using microsensors, oxygen concentrations were measured within seeds and in the silique space between seeds. At ambient external oxygen (21% [v/v]) in the light, oxygen fell to 17% (v/v) between and 0.8% (v/v) within seeds. A step-wise reduction of the external oxygen concentration led within 2 h to a further decrease of internal oxygen concentrations, and a step-wise increase of the external oxygen concentration up to 60% (v/v) resulted in an increase in internal oxygen that rose to 30% (v/v) between and 8% (v/v) within seeds. (b) The increase in oxygen levels in the seeds was accompanied by a progressive increase in the levels of ATP, UTP, and the ATP to ADP and UTP to UDP ratios over the entire range from 0% to 60% (v/v) external oxygen. (c) To investigate metabolic fluxes in planta, 14C-sucrose was injected into seeds, which remained otherwise intact within their siliques. The increase in oxygen in the seeds was accompanied by a progressive increase in the rate of lipid (including triacylglycerol), protein and cell wall synthesis, and an increase in glycolytic flux over a range from sub- to superambient oxygen concentrations. In contrast to lipid synthesis, starch synthesis was not significantly increased at superambient oxygen levels. The levels of fermentation products such as lactate and glycerol-3P increased only at very low (0%-4% [v/v]) external oxygen concentrations. (d) When 14C-acetate or 14C-acetyl-coenzyme A (CoA) was injected into seeds, label incorporation into triacylglycerol progressively increased over the whole range of external oxygen concentrations from 0% to 60% (v/v). (e) Stimulation of lipid synthesis was accompanied by an increase in sugar levels and a decrease in the levels of hexose-phosphates and acetyl-CoA, indicating sucrose unloading and the use of acetyl-CoA as possible regulatory sites. (f) Increased lipid synthesis was also accompanied by an increase in the maximal activities of invertase and diacylglycerol acyltransferase. (g) The developmental shift from starch to lipid storage between 15 and 45 d after flowering was accompanied by an increase in the seed energy state. (h) The results show that at ambient oxygen levels, the oxygen supply is strongly limiting for energy metabolism and biosynthetic fluxes in growing rape seeds, affecting lipid synthesis more strongly than starch synthesis. The underlying mechanisms and implications for strategies to increase yield and storage product composition in oilseed crops are discussed.
Chromosome Replication in Escherichia coli: Life on the Scales

At all levels of Life, systems evolve on the 'scales of equilibria'. At the level of bacteria, the individual cell must favor one of two opposing strategies and either take risks to grow or avoid risks to survive. It has been proposed in the Dualism hypothesis that the growth and survival strategies depend on non-equilibrium and equilibrium hyperstructures, respectively. It has been further proposed that the cell cycle itself is the way cells manage to balance the ratios of these types of hyperstructure so as to achieve the compromise solution of living on the two scales. Here, we attempt to re-interpret a major event, the initiation of chromosome replication in Escherichia coli, in the light of scales of equilibria. This entails thinking in terms of hyperstructures as responsible for intensity sensing and quantity sensing and how this sensing might help explain the role of the DnaA protein in initiation of replication. We outline experiments and an automaton approach to the cell cycle that should test and refine the scales concept.
Anti-Cancer Drugs Elicit Re-Expression of UDP-Glucuronosyltransferases in Melanoma Cells

The UDP-glucuronosyltransferase (UGT) family of enzymes plays a vital role in the detoxification of carcinogens as well as clearance of anti-cancer drugs. In humans, 19 UGT family members have been identified and are expressed in a tissue specific manner throughout the body. However, the UGTs have not been previously characterized in melanocytes or melanoma. In the present study, UGT2B7, UGT2B10, and UGT2B15 were identified as being normally expressed in human melanocytes. The same three UGT family members were also expressed in the primary melanoma cell line WM115. No UGT expression was detected in another primary melanoma cell line, WM3211, or in any metastatic melanoma cell line examined. These results suggest that UGT expression is lost during melanoma progression. Treatment of WM3211 or metastatic melanoma cell lines with anti-cancer agents (including vemurafenib) induced expression of UGT2B7, UGT2B10 and UGT2B15 demonstrating that melanoma cells retain the ability to re-express these same three UGTs. The corresponding increase in glucuronidation activity in melanoma cells following anti-cancer treatment was also observed. Furthermore, knockdown of UGT2B7 in WM115 cells sensitized these cells to treatment by adriamycin and epirubicin indicating that UGT2B7 is involved in resistance to these drugs. However, knockdown of UGT2B7 had no effect on temozolomide toxicity. Taken together, these results clearly demonstrate a role for UGTs in melanoma etiology. Since the UGTs are drug metabolism enzymes, we propose that re-expression of the UGTs constitutes a previously unsuspected mechanism for intratumoral drug resistance in melanoma.
SLIRP Regulates the Rate of Mitochondrial Protein Synthesis and Protects LRPPRC from Degradation

We have studied the in vivo role of SLIRP in regulation of mitochondrial DNA (mtDNA) gene expression and show here that it stabilizes its interacting partner protein LRPPRC by protecting it from degradation. Although SLIRP is completely dependent on LRPPRC for its stability, reduced levels of LRPPRC persist in the absence of SLIRP in vivo. Surprisingly, Slirp knockout mice are apparently healthy and only display a minor weight loss, despite a 50–70% reduction in the steady-state levels of mtDNA-encoded mRNAs. In contrast to LRPPRC, SLIRP is dispensable for polyadenylation of mtDNA-encoded mRNAs. Instead, deep RNA sequencing (RNAseq) of mitochondrial ribosomal fractions and additional molecular analyses show that SLIRP is required for proper association of mRNAs to the mitochondrial ribosome and efficient translation. Our findings thus establish distinct functions for SLIRP and LRPPRC within the LRPPRC-SLIRP complex, with a novel role for SLIRP in mitochondrial translation. Very surprisingly, our results also demonstrate that mammalian mitochondria have a great excess of transcripts under basal physiological conditions in vivo.
Problematic heroin use incidence trends in Spain.

AIMS To estimate the annual incidence of heroin use in Spain. PARTICIPANTS AND DESIGN Data on individuals' year of first heroin use (from 1971 to 2005), year of first heroin treatment between 1991 and 2005 and most frequent route of heroin administration when presenting to treatment were obtained from the Spanish Drug Observatory Register and used to calculate the delay between onset and treatment. By using a log-linear model approach it was possible to correct for missing observations (heroin users who presented for treatment before 1991 and those who had still not presented by the end of 2005) and to estimate heroin incidence over time. FINDINGS The estimated incidence of problematic heroin use in the population aged 15-44 peaked at 190 per 100,000 in 1980--after rising rapidly from less than 40 per 100,000 in 1971--and fell subsequently to about 8 per 100,000 in 2005. On average, incidence was five times higher in men. Injecting heroin incidence peaked and declined rapidly from 1980; as heroin smoking did not decline as rapidly, from 1985 onwards its estimated incidence has remained above that of heroin injecting. The delay between starting heroin use and entering treatment had a median of 3 years. CONCLUSIONS We demonstrate the utility of a method to estimate heroin incidence from analysis of observed trends in presentations at specialist drug treatment facilities. The estimates suggest that incidence of heroin use, especially injecting, has fallen since 1980 and is now lower than in the early 1970s.
Coupling between Intrinsic Prefrontal HbO2 and Central EEG Beta Power Oscillations in the Resting Brain

There is increasing interest in the intrinsic activity in the resting brain, especially that of ultraslow and slow oscillations. Using near-infrared spectroscopy (NIRS), electroencephalography (EEG), blood pressure (BP), respiration and heart rate recordings during 5 minutes of rest, combined with cross spectral and sliding cross correlation calculations, we identified a short-lasting coupling (duration s) between prefrontal oxyhemoglobin (HbO2) in the frequency band between 0.07 and 0.13 Hz and central EEG alpha and/or beta power oscillations in 8 of the 9 subjects investigated. The HbO2 peaks preceded the EEG band power peaks by 3.7 s in 6 subjects, with moderate or no coupling between BP and HbO2 oscillations. HbO2 and EEG band power oscillations were approximately in phase with BP oscillations in the 2 subjects with an extremely high coupling (squared coherence ) between BP and HbO2 oscillation. No coupling was identified in one subject. These results indicate that slow precentral (de)oxyhemoglobin concentration oscillations during awake rest can be temporarily coupled with EEG fluctuations in sensorimotor areas and modulate the excitability level in the brains’ motor areas, respectively. Therefore, this provides support for the idea that resting state networks fluctuate with frequencies of between 0.01 and 0.1 Hz (Mantini et.al. PNAS 2007).
Adolescent Vulnerabilities and Opportunities: Social and Contextual Perspective

1. Constructivist processes in adolescent development Eric Amsel and Judith Smetana Part I. Biological and Cognitive Perspective: 2. Structural brain magnetic resonance imaging of typically developing children and adolescents Jay N. Giedd, Armin Raznahan, Nancy R. Lee, Catherine Weddle, Maria Liverpool, Michael Stockman, Elizabeth Malloy, Liv Clasen, Jonathan Blumenthal, Rhoshel K. Lenroot and Francois Lalonde 3. Adolescent risk-taking: a social neuroscience perspective Laurence Steinberg 4. What are the cognitive skills adolescents need for life in the 21st century? Deanna Kuhn and Amanda Holman 5. Hypothetical thinking in adolescence: its nature, development, and applications Eric Amsel Part II. Social and Contextual Perspective: 6. Testing, Testing: everyday storytelling and the construction of adolescent identity Avril Thorne and Lauren Shapiro 7. Adolescents' social reasoning and relationships with parents: conflicts and coordinations within and across domains Judith G. Smetana 8. Representations, process and development: a new look at friendship in early adolescence William M. Bukowski, Melissa Simard, Marie Eve Dubois and Luz Stella Lopez 9. Schools, peers, and the big picture of adolescent development Robert Crosnoe.