Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular outflows towards O-type young stellar objects

Context. The formation of massive stars is not well-understood and requires detailed observational studies in order to discriminate between the different proposed star formation models. Aims. We have searched for massive molecular outflows in a sample of high-mass star forming regions, and we have characterised both the outflow properties and those of their associated molecular clumps. With a sample composed largely of more luminous objects than previous ones, this work complements analogous surveys performed by other authors by adding the missing highest luminosity sources. Methods. The sample under study has been selected so as to favour the earliest evolutionary phases of star formation, and is composed of very luminous objects ( L bol > 2$\times$10 4 $L_{\odot}$ and up to ~10 6 $L_{\odot}$), possibly containing O-type stars. Each source has been mapped in 13 CO(2-1) (an outflow tracer) and C 18 O(2-1) (an ambient gas tracer) with the IRAM-30 m telescope on Pico Veleta (Spain). Results. The whole sample shows high-velocity wings in the 13 CO(2-1) spectra, indicative of outflowing motions. In addition, we have obtained outflow maps in 9 of our 11 sources, which display well-defined blue and/or red lobes. For these sources, the outflow parameters have been derived from the line wing 13 CO(2-1) emission. An estimate of the clump masses from the C 18 O(2-1) emission is also provided and found to be comparable to the virial masses. From a comparison between our results and those found by other authors at lower masses, it is clear that the outflow mechanical force increases with the bolometric luminosity of the clump and with the ionising photon rate of the associated Hii regions, indicating that high-mass stars drive more powerful outflows. A tight correlation between outflow mass and clump mass is also found. Conclusions. Molecular outflows are found to be as common in massive star forming regions as in low-mass star forming regions. This, added to the detection of a few tentative large-scale rotating structures suggests that high-mass stars may generally form via accretion, as low-mass stars.
Prioritizing 2nd and 3rd order interactions via support vector ranking using sensitivity indices on static Wnt measurements

It is widely known that the sensitivity analysis plays a major role in computing the strength of the influence of involved factors in any phenomena under investigation. When applied to expression profiles of various intra/extracellular factors that form an integral part of a signaling pathway, the variance and density based analysis yields a range of sensitivity indices for individual as well as various combinations of factors. These combinations denote the higher order interactions among the involved factors that might be of interest in the working mechanism of the pathway. For example, DACT3 is known to be a epigenetic regulator of the Wnt pathway in colorectal cancer and subject to histone modifications. But many of the nth ≥ 2 order interactions of DACT3 that might be influential have not been explored/tested. In this work, after estimating the individual effects of factors for a higher order combination, the individual indices are considered as discriminative features. A combination, then is a multivariate feature set in higher order (≥ 2). With an excessively large number of factors involved in the pathway, it is difficult to search for important combinations in a wide search space over different orders. Exploiting the analogy of prioritizing webpages using ranking algorithms, for a particular order, a full set of combinations of interactions can then be prioritized based on these features using a powerful ranking algorithm via support vectors. The computational ranking sheds light on unexplored combinations that can further be investigated using hypothesis testing based on wet lab experiments. Here, the basic framework and results obtained on 2nd and 3rd order interactions for members of family of DACT, SFRP, DKK (to name a few) in both normal and tumor cases is presented using a static data set. Significance The search and wet lab testing of unknown biological hypotheses in the form of combinations of various intra/extracellular factors that are involved in a signaling pathway, costs a lot in terms of time, investment and energy. To reduce this cost of search in a vast combinatorial space, a pipeline has been developed that prioritises these list of combinations so that a biologist can narrow down their investigation. The pipeline uses kernel based sensitivity indices to capture the influence of the factors in a pathway and employs powerful support vector ranking algorithm. The generic workflow and future improvements are bound to cut down the cost for many wet lab experiments and reveal unknown/untested biological hypothesis.
Glutamate supplementation is associated with improved glucose metabolism following carbohydrate ingestion in healthy males

Glutamate is linked to the glycolytic process, particularly when co-ingested with carbohydrate, but its effects on glucose metabolism are poorly characterised. The present study aimed to (1) specifically examine the effects of carbohydrate administration on circulating glutamate concentrations and (2) investigate the effect of increased glutamate availability, independent of carbohydrate ingestion, on glucose metabolism. A total of nine participants underwent four trials: (1) glutamate supplement+carbohydrate drink (GLU+CHO); (2) glutamate supplement+placebo drink (GLU); (3) placebo supplement+carbohydrate drink (CHO); (4) placebo supplement+placebo drink (CON). Following a fasting blood sample, participants ingested monosodium l-glutamate (MSG; 150 mg/kg body weight) or placebo capsules at each trial followed by a 75 g carbohydrate or a non-energy placebo drink 30 min later. Blood samples were taken at 0, 10, 20, 30, 40, 50, 60, 75, 90, 105 and 120 min. Plasma glutamate concentrations were significantly elevated relative to baseline during the GLU (approximately 10-fold) and GLU+CHO trials (approximately 6-fold). The glucose response to a carbohydrate load was blunted when glutamate was increased in the circulation (peak serum glucose: 5·50 (se 0·54) mmol/l during the GLU+CHO trial v. 7·69 (se 0·53) mmol/l during the CHO trial, P< 0·05). On average, c-peptide results revealed that insulin secretion did not differ between the GLU+CHO and CHO trials; however, four participants demonstrated increased insulin secretion during the GLU+CHO trial and five participants demonstrated decreased insulin secretion under the same conditions. In conclusion, when administration is staggered, MSG and carbohydrate supplementation can be used to manipulate plasma glutamate; however, future studies should control for this dichotomous insulin response.
CLM and NCSOCKS : a technical report

There is an increasing demand for the development of Nomadic Computing applications, which are sensible to connection and location status. For these reasons, an Application Programming Interface (API) specifically tailored for Nomadic environments has to be provided. The purpose of this report is to illustrate our efforts in this direction by explaining the technical details of the Nomadic Computing SOCKetS (NCSOCKS), and the underlaying Connection and Location Management (CLM) layer, designed to help developers of Nomadic Computing applications. WP 2 Numero TR-WEBMINDS-25 Data 22/07/2004 Tipo di prodotto Technical Report Numero di pagine 12 Unità operativa CINI Napoli Persona da contattare Domenico Cotroneo Dipartimento di Informatica e Sistemistica Università degli Studi di Napoli Federico II Via Claudio 21, 80125 Napoli, Italy cotroneo@unina.it
Peripheral sensitisation of nociceptors via G-proteindependent potentiation of mechanotransduction currents

Mechanical stimuli impinging on the skin are converted into electrical signals by mechanically gated ion channels located at the peripheral nerve endings of dorsal root ganglion (DRG) neurons. Under inflammatory conditions sensory neurons are commonly sensitised to mechanical stimuli; a putative mechanism that may contribute to such sensitisation of sensory neurons is enhanced responsiveness of mechanotransduction ion channels. Here we show that the algogens UTP and ATP potentiate mechanosensitive RA currents in peptidergic nociceptive DRG neurons and reduce thresholds for mechanically induced action potential firing in these neurones. Pharmacological characterisation suggests that this effect is mediated by the Gq‐coupled P2Y2 nucleotide receptor. Moreover, using the in vitro skin nerve technique, we show that UTP also increases action potential firing rates in response to mechanical stimuli in a subpopulation of skin C‐fibre nociceptors. Together our findings suggest that UTP sensitises a subpopulation of cutaneous C‐fibre nociceptors via a previously undescribed G‐protein‐dependent potentiation of mechanically activated RA‐type currents.
The association of PTEN hypermethylation and breast cancer: a meta-analysis

Objective Phosphatase and tensin homolog (PTEN) deleted on chromosome 10, as a tumor suppressor gene, is crucial for the development of both familial and sporadic breast cancer (BC). The aim of this study was to perform a meta-analysis to evaluate the clinicopathological significance of PTEN promoter hypermethylation in BC. Methods A comprehensive literature search was made in PubMed, Embase, Google Scholar, Chinese database (China National Knowledge Infrastructure [CNKI]), and Web of Science. The analysis of pooled data was performed with Review Manager 5.2. The fixed-effects or random-effects models were used to evaluate odds ratios (ORs) and 95% confidence intervals (CIs). Results The meta-analysis included eight studies and a total of 923 patients. The frequency of PTEN promoter hypermethylation was significantly increased in ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) compared to normal breast tissues (OR =22.53, P=0.0002 and OR =22.86, P<0.00001, respectively). However, the frequency of PTEN promoter hypermethylation was similar between IDC and DCIS. Additionally, PTEN methylation was not significantly correlated to estrogen receptor (ER) or human epidermal growth factor type 2 (HER-2) status in patients with BC. Conclusion PTEN promoter hypermethylation is significantly associated with the risk of DCIS and IDC, suggesting PTEN promoter hypermethylation is a valuable biomarker for diagnosis of BC.
Modeling motion flow using tensor dynamic textures

As a family of visual patterns in moving scenes with certain temporal regularity, dynamic textures are powerful visual cues for people to understand things; hence, effective models are needed for relevant applications. Considering that image sequences are really tensor time series, this paper proposes a tensor dynamic texture model to represent dynamic texture videos, and a sub-optimal algorithm to estimate the model parameters. Our tensor-based method can capture multiple interactions and essential structures in videos. Experimental results on dynamic texture synthesis show that the proposed method not only achieved a better visual quality, but also a smaller model size and a less time cost. The maximum PSNR gain achieves 2.36 dB, and the maximum model size reduction achieves 49.68%.
From Architectural to Behavioural Specification of Services ? — An implementation of SRML into COWS —

Many e orts are currently devoted to provide software developers with methods and techniques that can endow service-oriented computing with systematic and accountable engineering practices. To this purpose, a number of languages and calculi have been proposed within the Sensoria project that ad- dress di erent levels of abstraction of the software engineering process. Here, we report on two such languages and the way they can be formally related within an integrated approach that can lead to verifiable development of service compo- nents from more abstract architectural models of business activities.
The Art of Coaching Teams: Building Resilient Communities that Transform Schools

DESCRIPTION The missing how-to manual for being an effective team leader The Art of Coaching Teams is the manual you never received when you signed on to lead a team. Being a great teacher is one thing, but leading a team, or team development, is an entirely different dynamic. Your successes are public, but so are your failures —and there's no specific rubric or curriculum to give you direction. Team development is an art form, and this book is your how-to guide to doing it effectively. You'll learn the administrative tasks that keep your team on track, and you'll gain access to a wealth of downloadable tools that simplify the "getting organized" process. Just as importantly, you'll explore what it means to be the kind of leader that can bring people together to accomplish difficult tasks. You'll find practical suggestions, tools, and clear instructions for the logistics of team development as well as for building trust, developing healthy communication, and managing conflict.
Talent Management and Its Relationship to Successful Veteran Transition Into the Civilian Workplace

The Problem Historical trends reveal that after protracted armed conflict, the U.S. Military has experienced troop reductions (Shanker & Cooper, 2014). Over 200,000 service members from the recent wars in Iraq and Afghanistan have left active duty each year since 2014. For veterans who successfully navigate the hiring process, transitioning into a civilian workplace may prove daunting (Minnis & Wang, 2011), particularly regarding retention. Some studies reveal that nearly half of newly hired veterans left their first post-military job within the first year of hire (Maury, Stone, & Roseman, 2014). The Solution This article explored strategic talent management planning considerations and their relationship to military-to-private sector transition processes, from the perspective of the organization and veterans who made successful transitions. Through the utilization of a conceptual framework focused on integrated processes across organizational levels, we suggest that human resource development (HRD) practitioners can effectively integrate veterans into the workplace and assist organizations with maintaining optimally performing workforces by identifying strategic relationships between veteran transition processes and organizational talent management objectives. The Stakeholders Through the use of a framework, HRD practitioners enhance their ability to assist organizations in attracting, developing, and retaining veteran talent using a systematic approach.
Loss differentiation based back off strategy for correlated channels in 802.11

The paper proposes two schemes for contention resolution in 802.11 MAC namely modified back off strategy and estimation based back off strategy. The back off strategies provided a way to resolve contention for access to wireless channel which is continuously changing and difficult to model in a set of parameters. Differentiation between packet loss due to channel error and collision in 802.11 MAC is essential for the above two schemes to exist. Modified strategy tries to find the optimum back off period on loss due to channel error by taking the advantages of both the current strategy implemented in 802.11 MAC and the Return to Zero on channel error (ROCE) strategy. The Estimation based approach shows how by analyzing the channel for a period of time, we can predict the best back off interval in case of channel error. The aim is to maximize the throughput while being fair to all contending users. Simulation of the above two scheme suggest their superiority to the currently implemented scheme. Estimation based approach is better than other schemes for static correlated WLAN channel.
La prépondérance de la performance sociale sur la performance financière des institutions de microfinance de l’Afrique subsaharienne : mythe ou réalité ?

Les institutions de microfinance jouent un role crucial dans la lutte contre la pauvrete et l’exclusion en Afrique subsaharienne. Ainsi, la performance sociale et la performance financiere constituent des enjeux majeurs. Dans cette perspective, cet article vise a etudier la preeminence de la portee sociale sur la rentabilite et l’autosuffisance operationnelle et montre a travers un echantillon de 279 IMF de l’annee 2012 que la performance financiere est plutot preponderante sur la performance sociale.
Ripple-free control response by using a fractional order hold device

In digital control, discrete-time signal reconstruction is usualy carried out by the zero-order hold (ZOH), although other options exist which exhibit interesting properties. A remarkable alternative is the fractional-order hold (FROH), which provokes no intersample ripple under steady state and, if properly tuned, can often place the discretized plant model z-domain zeros in more convenient locations than the ZOH. This zero placing technique, in turn, gives rise to closed-loop performance improvements for many cases. However, since it is formulated in the z-domain, it cannot anticipate continuous-time closed-loop behaviour. Besides, going through zero placement is burdensome, especially for high-order models. This work presents a new and simpler method which directly links the tuning of the FROH with some desired closed-loop features, bypassing zero placement. It is based on the frequency domain, which makes it possible to capture the continuous-time behaviour. The simulations performed have shown clear improvements over zero placement, in terms of time-domain performance figures, intersample behaviour, and the energy consumed in step responses.
From grand tour to virtual tour: Italy through the stereoscope in 1900

In 1903, Underwood & Underwood published Italy through the Stereoscope: Journeys in and about Italian cities, a multimodal set that provided an immersive travel experience by combining the use of a visual device (the stereoscope and stereoviews), localisation tools (the maps), and a written commentary on each view. The paper argues that this ‘medium’, which was introduced as a realistic and immersive visual reproduction of the world, was an innovative forerunner of modern virtual–reality technologies. The visual three-dimensional effect obtained by the stereoviews is just one of the characteristics meant to enhance the ‘virtual’ experience of the viewer. The author analyses the rhetorical means, strictly intertwined with the photographic representations, to reinforce the impression and emotion and to replace the physical experience of a tour with that of an armchair traveller. The framing of the picture, the choice of the points of view, and the style of staging and posing the people reveal an international standard. In spite of their claim of realistic representation, this vision is not ideologically neutral, and the analysis of this set reveals the biases and prejudices towards not only strangers but also the ‘old’ technology of 2D photography. For social and economic reasons, the ancient practice of taking the grand tour faded, but the conspicuous consumption of this medium allowed the middle class to gain cultural capital with a 3D visual tour in order to claim refinement.
Interference-Aware Service Differentiation in Multihop Wireless Networks

In this paper, we provide service differentiation with interference consideration for traffic of different priorities in multi-hop wireless networks. Specifically, we propose a framework to support different service levels in terms of queuing delays at each intermediate path node for concurrent sessions of different priorities. We formulate an interference-aware bandwidth allocation problem which jointly considers the interference and resource allocation problems. We then develop a sub-gradient algorithm to solve this problem in a distributed manner. The simulation results show that our proposed algorithm achieves different levels of bandwidth allocation efficiently with a limited number of iterations. In addition, our algorithm scales well when the number of sessions and the size of the session increase.
Predictive data mining in clinical medicine: a focus on selected methods and applications

Predictive data mining in clinical medicine deals with learning models to predict patients' health. The models can be devoted to support clinicians in diagnostic, therapeutic, or monitoring tasks. Data mining methods are usually applied in clinical contexts to analyze retrospective data, thus giving healthcare professionals the opportunity to exploit large amounts of data routinely collected during their day‐by‐day activity. Moreover, clinicians can nowadays take advantage of data mining techniques to deal with the huge amount of research results obtained by molecular medicine, such as genetic or genomic signatures, which may allow transition from population‐based to personalized medicine. The current challenge is to exploit data mining to build models able to take into account the dynamic and temporal nature of clinical care and to exploit the variety of information available at the bedside. This review describes the main features of predictive clinical data mining and focus on two specific aspects of particular interest: the methods able to deal with temporal data and the efforts performed to translate molecular medicine results into clinically useful data mining models. © 2011 John Wiley & Sons, Inc. WIREs Data Mining Knowl Discov 2011 1 416–430 DOI: 10.1002/widm.23
Percolation in the Hyperbolic Plane Extended Abstract

The Voronoi model for percolation in H 2. Percolation has been studied extensively in R d and in lattices of R d. In 1], we have proposed some conjectures about percolation in quite general settings. Here, we begin the investigation of percolation in hyperbolic space, and concentrate on dimension 2. It turns out that percolation in hyperbolic space is very diierent from percolation in Euclidean geometry. The diier-ence is reminiscent, and indeed analogous, to the similar disparity of the behaviour of Brownian motion in the two settings. Let us start by describing the Voronoi percolation model, which seems to be more suitable than lattice models or the lily-pad model. We have recently found that the Voronoi model is useful in the study of the conformal invariance conjecture for critical percolation. Fix two parameters, > 0; p 2 0; 1]. Let X w be a Poisson point process in the hyperbolic plane H 2 , with density pp, and let X b be an independent Poisson point process with density (1 ? p). Then X = X w X b is a Poisson point process with density. For each x 2 X, let T(x; X) denote the Voronoi tile of x in the Voronoi tiling T(X); that is, The point x is called the nucleus of the tile T(x; X). Let W = W(X w ; X b) denote the union of all tiles with nucleus in X w , and let B = B(X w ; X b) denote the union of all tiles with nucleus in X b. W is called the white set, and B is called the black set. A cluster is a connected component of W or of B. A cluster is unbounded if it has innnite diameter. We say that white black] percolates, if there are unbounded clusters in W B]. Let W be the set of all parameter pairs (; p) such that with positive probability (hence with probability 1) white percolates, and let B be the set of all parameter pairs (; p) such that with positive probability black percolates. By symmetry, it is clear that (; p) 2 W is equivalent to (; 1 ? p) 2 B. Since the hypercolic plane admits no homotheties, unlike the Euclidean case, there is no simple equivalence between percolation with parameters (; p) and (0 ; p), 6 = 0. Actually, a change in is …