Miracle-dz/UniFAR-FTUs huggingface dataset:
BIROn - Birkbeck Institutional Research Online sensitivity to spatial in

Healthy aging is associated with decline in social, emotion, and identity perception, which is frequently attributed to deterioration of structures involved in social inference. It is believed that this decline is unlikely to be a result of perceptual aberrations due to intact (corrected) visual acuity. Nevertheless, the present studies examine whether more particular perceptual aberrations may be present in healthy aging, that could in principle contribute to such difﬁculties. The present study examined the possibility that particular deﬁcits in conﬁgural processing impair the perception of faces in healthy aging. Across two signal detection experiments, we required a group of healthy older adults and matched younger adults to detect changes in images of faces that could differ either at the local, featural level, or in conﬁguration of these features. In support of our hypothesis, older adults were particularly impaired in detecting conﬁgural changes, relative to detecting changes in features. The impairments were found for both upright and inverted faces and were similar in a task with images of inanimate objects (houses). Drift diffusion modelling suggested that this decline related to reduced evidence accumulation rather than a ten-dency to make conﬁgural judgments based on less evidence. These ﬁndings indicate that domain-general problems processing conﬁgural information contribute to the difﬁculties with face processing in healthy aging, and may in principle contribute to a range of higher-level social difﬁculties e with implications also for other groups exhibiting similar patterns in perception and understanding. The Authors. Published by Elsevier Ltd. This is
The driving of turbulence in simulations of molecular cloud formation and evolution

Molecular clouds are to a great extent influenced by turbulent motions in the gas. Numerical and observational studies indicate that the star formation rate and efficiency crucially depend on the mixture of solenoidal and compressive modes in the turbulent acceleration field, which can be quantified by the turbulent driving parameter b. For purely solenoidal (divergence-free) driving previous studies showed that b=1/3 and for entirely compressive (curl-free) driving b=1. In this study, we determine the evolution of the turbulent driving parameter b in magnetohydrodynamical simulations of molecular cloud formation and evolution. The clouds form due to the convergence of two flows of warm neutral gas. We explore different scenarios by varying the magnitude of the initial turbulent perturbations in the flows. We show that the driving mode of the turbulence within the cloud strongly fluctuates with time and exhibits no clear correlation with typical cloud properties, such as the cloud mass and the (Alfven) Mach number. We specifically find that $b$ strongly varies from b=0.3 to b=0.8 on timescales t<5 Myr, where the timescale and range of variation can change from cloud to cloud. This rapid change of b from solenoidal to compressive driving is primarily associated with global contraction of the cloud and subsequent onset of star formation. We conclude that the effective turbulence driving parameter should be treated as a free parameter that can vary from solenoidal to compressive in both time and space.
Anti-in ﬂ ammatory effects of FS48, the ﬁ rst potassium channel inhibitor from the salivary glands of the ﬂ ea Xenopsylla cheopis

The voltage-gated potassium (Kv) 1.3 channel plays a crucial role in the immune responsiveness of T-lymphocytes and macrophages, presenting a potential target for treatment of immune- and in ﬂ ammation related-diseases. FS48, a protein from the rodent ﬂ ea Xenopsylla cheopis , shares the three disul ﬁ de bond feature of scorpion toxins. However, its three-dimensional structure and biological function are still unclear. In the present study, the structure of FS48 was evaluated by circular dichroism and homology modeling. We also described its in vitro ion channel activity using patch clamp recording and investigated its anti-in ﬂ ammatory activity in LPS-induced Raw 264.7 macrophage cells and carrageenan-induced paw edema in mice. FS48 was found to adopt a common αββ structure and contain an atypical dyad motif. It dose-dependently exhibited the Kv1.3 channel in Raw 264.7 and HEK 293T cells, and its ability to block the channel pore was demonstrated by the kinetics of activation and competition binding with tetraethylammonium. FS48 also
The Correlation of the N A Measurements by Counting 28 Si Atoms

An additional value of the Avogadro constant was obtained by counting the atoms in isotopically enriched Si spheres. With respect to the previous determination, the spheres were etched and repolished to eliminate metal contaminations and to improve the round-ness. In addition, all the input quantities—molar mass, lattice parameter, mass, and volume—were remeasured aiming at a smaller uncertainty. In order to make the values given in Andreas et al. 48 , S1 (2011)] and Azuma et al. , 360 usable for a least squares adjustment, we report about the estimate of their correlation. C Publishing LLC.
Radio and infrared study of southern H II regions G346.056-0.021 and G346.077-0.056

Aims. We present a multiwavelength study of two southern Galactic H II regions G346.056-0.021 and G346.077-0.056 which are located at a distance of 10.9 kpc. The distribution of ionized gas, cold and warm dust and the stellar population associated with the two H II regions are studied in detail using measurements at near-infrared, mid-infrared, far-infrared, submillimeter and radio wavelengths. Methods. The radio continuum maps at 1280 and 610 MHz were obtained using the Giant Metrewave Radio Telescope to probe the ionized gas. The dust temperature, column density and dust emissivity maps were generated by using modified blackbody fits in the far-infrared wavelength range 160 - 500 {\mu}m. Various near- and mid-infrared colour and magnitude criteria were adopted to identify candidate ionizing star(s) and the population of young stellar objects in the associated field. Results. The radio maps reveal the presence diffuse ionized emission displaying distinct cometary morphologies. The 1280 MHz flux densities translate to ZAMS spectral types in the range O7.5V - O7V and O8.5V - O8V for the ionizing stars of G346.056-0.021 and G346.077-0.056, respectively. A few promising candidate ionizing star(s) are identified using near-infrared photometric data. The column density map shows the presence of a large, dense dust clump enveloping G346.077-0.056. The dust temperature map shows peaks towards the two H II regions. The submillimetre image shows the presence of two additional clumps one being associated with G346.056-0.021. The masses of the clumps are estimated to range between {\sim} 1400 to 15250 M{\sun}. Based on simple analytic calculations and the correlation seen between the ionized gas distribution and the local density structure, the observed cometary morphology in the radio maps is better explained invoking the champagne-flow model.
Diagnostic and Prognostic Biomarkers in Renal Clear Cell Carcinoma

Renal clear cell carcinoma (ccRCC) comprises over 75% of all renal tumors and arises in the epithelial cells of the proximal convoluted tubule. Molecularly ccRCC is characterized by copy number alterations (CNAs) such as the loss of chromosome 3p and VHL inactivation. Additional driver mutations (SETD2, PBRM1, BAP1, and others) promote genomic instability and tumor cell metastasis through the dysregulation of various metabolic and immune-response pathways. Many researchers identified mutation, gene expression, and proteomic signatures for early diagnosis and prognostics for ccRCC. Despite a tremendous influx of data regarding DNA alterations, gene expression, and protein expression, the incorporation of these analyses for diagnosis and prognosis of RCC into the clinical application has not been implemented yet. In this review, we focused on the molecular changes associated with ccRCC development, along with gene expression and protein signatures, to emphasize the utilization of these molecular profiles in clinical practice. These findings, in the context of machine learning and precision medicine, may help to overcome some of the barriers encountered for implementing molecular profiles of tumors into the diagnosis and treatment of ccRCC.
Structure in the disc of epsilon Aurigae – analysis of ARCES and TripleSpec spectra from the 2010 eclipse

Context: Worldwide interest in the recent eclipse of epsilon Aurigae resulted in the generation of several extensive data sets, including those related to high resolution spectroscopic monitoring. This lead to the discovery, among other things, of the existence of a mass transfer stream, seen notably during third contact. Aims: We explored spectroscopic facets of the mass transfer stream during third contact, using high resolution spectra obtained with the ARCES and TripleSpec instruments at Apache Point Observatory. Methods: One hundred and sixteen epochs of data between 2009 and 2012 were obtained, and equivalent widths and line velocities measured, selected according to reports of these being high versus low eccentricity disk lines. These datasets also enable greater detail to be measured of the mid-eclipse enhancement of the He I 10830A line, and the discovery of the P Cygni shape of the Pa beta line at third contact. Analysis: We found evidence of higher speed material, associated with the mass transfer stream, persisting between third and fourth eclipse contacts. We visualize the disk and stream interaction using SHAPE software, and use CLOUDY software to estimate that the source of the enhanced He I 10830A absorption arises from a region with log n = 10 (/cm3) and temperature of 20,000 K consistent with a mid B type central star. Results and Next Steps: Van Rensbergen binary star evolutionary models are somewhat consistent with the current binary parameters for the case of a 9 plus 8 solar mass initial binary, evolving into a 2.3 and 14.11 solar mass end product after 35 Myr. Prior to the next eclipse, it is possible to make predictions which suggest that continued monitoring will help resolve standing questions about this binary.
Prospective Cohort Real-World Study on Neuroendocrine Tumor Patient's Quality of Life During Peptide Receptor Radionuclide Therapy With 177Lu-DOTATATE

Objective The aim of this study was to report lutetium-177 (177Lu)–DOTATATE radionuclide therapy from a patient perspective and their health-related quality of life. Methods This prospective cohort study, including adult patients treated with 177Lu-DOTATATE. At the beginning of the follow-up (T1), socioeconomic and clinical information was collected, and European Organisation for Research and Treatment of Cancer Quality of Life Questionnaires C30-v3 and GI.NET21 were applied. Follow-up was performed at the third cycle (T2) and 3 months after the end of treatment (T3). Student t test for paired samples was used to compare quality of life at T1, T2, and T3. Results Thirty-eight patients with stage IV disease and mean age of 52.54 (standard deviation, 12.49) years were included. The most prevalent site was the gastrointestinal tract (39.7%). Global health improved between T2 and T3 (P = 0.022) and T1 and T3 (P = 0.038). Functional scales did not indicate significant changes between the periods. Regarding symptoms, significant improvements in nausea and vomiting and gastrointestinal symptoms were observed between T2 and T3 (P = 0.012 and 0.029) and T1 and T3 (P = 0.012 and 0.011), respectively. Conclusions 177Lu-DOTATATE therapy improved global health and reduced disease-related symptoms in NET patients, positively impacting health-related quality of life.
Study of dark matter and QCD-charged mediators in the quasidegenerate regime

We study a scenario in which the only light new particles are a Majorana fermion dark matter candidate and one or more QCD-charged scalars, which couple to light quarks. This scenario has several interesting phenomenological features if the new particles are nearly degenerate in mass. In particular, LHC searches for the light scalars have reduced sensitivity, since the visible and invisible products tend to be softer. Moreover, dark matter-scalar co-annihilation can allow even relatively heavy dark matter candidates to be consistent thermal relics. Finally, the dark matter nucleon scattering cross section is enhanced in the quasi-degenerate limit, allowing direct detection experiments to use both spin-independent and spin-dependent scattering to probe regions of parameter space beyond those probed by the LHC. Although this scenario has broad application, we phrase this study in terms of the MSSM, in the limit where the only light sparticles are a bino-like dark matter candidate and light-flavored squarks.
Polycyclic Aromatic Hydrocarbon Emission Toward the Galactic Bulge

We examine polycyclic aromatic hydrocarbon (PAH), dust, and atomic/molecular emission toward the Galactic bulge using Spitzer Space Telescope observations of four fields: C32, C35, OGLE, and NGC 6522. These fields are approximately centered on (l, b) = (0.°0, 1.°0), (0.°0, −1.°0), (0.°4, −2.°4), and (1.°0, −3.°8), respectively. Far-infrared photometric observations complement the Spitzer/IRS spectroscopic data and are used to construct spectral energy distributions. We find that the dust and PAH emission are exceptionally similar between C32 and C35 overall, in part explained due to their locations—they reside on or near boundaries of a 7 Myr old Galactic outflow event and are partly shock-heated. Within the C32 and C35 fields, we identify a region of elevated Hα emission that is coincident with elevated fine-structure and [O iv] line emission and weak PAH feature strengths. We are likely tracing a transition zone of the outflow into the nascent environment. PAH abundances in these fields are slightly depressed relative to typical ISM values. In the OGLE and NGC 6522 fields, we observe weak features on a continuum dominated by zodiacal dust. SED fitting indicates that thermal dust grains in C32 and C35 have temperatures comparable to those of diffuse, high-latitude cirrus clouds. Little variability is detected in the PAH properties between C32 and C35, indicating that a stable population of PAHs dominates the overall spectral appearance. In fact, their PAH features are exceptionally similar to that of the M82 superwind, emphasizing that we are probing a local Galactic wind environment.
A new template background estimate for source searching in TeV gamma-ray astronomy

A new method is described that permits quickly and easily, a 2-dimensional search for TeV-ray sources over large fields of view (6) with instruments utilising the imaging atmospheric ˇ Cerenkov technique. It employs as a background estimate, events normally rejected according to a cosmic-ray background rejection criterion based on image shape, but with reconstructed directions overlapping the source of interest. This so-called template background model is demonstrated using example data taken with the stereoscopic HEGRA System of ˇ Cerenkov Telescopes. Discussion includes comparisons with a conventional background estimate and limitations of the model. The template model is well suited to the search for point-like, moderately extended sources and combinations thereof, and compensates well for localised systematic changes in cosmic-ray background response.
The WARPS survey - IV. The X-ray luminosity-temperature relation of high-redshift galaxy clusters

We present a measurement of the cluster X-ray luminosity–temperature (L–T) relation out to high redshift (z∼0.8). Combined ROSAT PSPC spectra of 91 galaxy clusters detected in the Wide Angle ROSAT Pointed Survey (WARPS) are simultaneously fitted in redshift and luminosity bins. The resulting temperature and luminosity measurements of these bins, which occupy a region of the high-redshift L–T relation not previously sampled, are compared with existing measurements at low redshift in order to constrain the evolution of the L–T relation. We find the best fit to low-redshift (z 1 keV, to be L∝T3.15±0.06. Our data are consistent with no evolution in the normalization of the L–T relation up to z∼0.8. Combining our results with ASCA measurements taken from the literature, we find η=0.19±0.38 (for Ω0=1, with 1σ errors) where LBol∝(1+z)ηT3.15, or η=0.60±0.38 for Ω0=0.3. This lack of evolution is considered in terms of the entropy-driven evolution of clusters. Further implications for cosmological constraints are also discussed.
The Radio-Optical Jet in NGC 3862 from Parsec to Subkiloparsec Scales

We have observed the radio source in NGC 3862 (3C 264) simultaneously with the European VLBI network and the MERLIN arrays, obtaining detailed images of its radio structure from parsec to subkiloparsec scales. 3C 264 shows a one-sided jet with evident variations in its morphological properties with distance. We have analyzed Hubble Space Telescope optical data of NGC 3862, finding a one-to-one correspondence between radio and optical features in the jet. The radio-to-optical spectral index is approximately constant along the jet. Synchrotron appears as the most plausible mechanism for the observed jet emission at radio and optical wavelengths. Local particle reacceleration or, alternatively, deviation from the condition of equipartition, are plausible mechanisms to explain the low synchrotron cooling and constant spectral index in the jet of 3C 264.
A Useful Matrix Decomposition and Its Statistical Applications in Linear Regression

It is well known that if V is a symmetric positive definite n × n matrix, and (X: Z) is a partitioned orthogonal n × n matrix, then In this article, we show how useful we have found the formula (*), and in particular, its version and present several related formulas, as well as some generalized versions. We also include several statistical applications.
Multiple-camera tracking system with seamless object handover

This paper presents a new method for seamless tracking a moving object by using multiple fixed cameras controlled by a single processor. For seamless tracking a moving object with multiple cameras, we should extract important features of the object from input images captured by multiple cameras. Because two adjacent cameras, in general, have different parameters, such as: zooming ratio, color distribution, and direction of view, we use the color information of overlapped region and feature vector, such as object's ratio and moving direction. We first investigate the distribution of color component in the overlapped region. We then use the results to discriminate the target object and to hand over the current view. Experimental results show the feasibility of the proposed seamless tracking method and its real-time applications.
Creation of classical and quantum fluxons by a current dipole in a long Josephson junction

We study static and dynamical properties of fluxons in a long annular Josephson junction (JJ) with a current injected at one point and collected back at a close point. Uniformly distributed dc bias current with density $\ensuremath{\gamma}$ is applied too. We demonstrate that, in the limit of the infinitely small size of the current dipole, the critical value of $\ensuremath{\gamma},$ above which static phase distributions do not exist, that was recently found (in the Fraunhofer's analytical form) for the annular JJ with the length much smaller than the Josephson penetration length is valid irrespective of the junction's length, including infinitely long JJ's. In a long annular JJ, the dipole generates free fluxon(s) if $\ensuremath{\gamma}$ exceeds the critical value. For long JJ's, we also find another critical value (in an analytical form too), which is always slightly smaller than the Fraunhofer value, except for points where the dipole strength is $2\ensuremath{\pi}N$ with integer N, and both values vanish. The static phase configuration which yields the new critical value is based on an unstable fluxon-antifluxon bound state, therefore it will probably not manifest itself in the usual (classical) regime. However, it provides for a dominating instanton configuration for tunnel birth of a free fluxon, hence it is expected to determine a quantum-birth threshold for fluxons at ultralow temperatures. We also consider the interaction of a free fluxon with the complex consisting of the current dipole and antifluxon pinned by it. A condition for suppression of the net interaction force, which makes the long JJ nearly homogeneous for the free fluxon, is obtained in an analytical form. The analytical results are compared with numerical simulations. The analysis presented in the paper is relevant to the recently proposed new experimental technique of inserting fluxons into annular Josephson junctions.
Relativistic Components of the Ultra-fast Outflow in the Quasar PDS 456 from Chandra/HETGS, NuSTAR, and XMM-Newton Observations

We present the spectral analysis of Chandra/High Energy Transmission Grating Spectrometer (HETGS) and NuSTAR observations of the quasar PDS 456 from 2015, and XMM-Newton and NuSTAR archival data from 2013 to 2014, together with Chandra/HETGS data from 2003. We analyzed these three different epochs in a consistent way, looking for absorption features corresponding to highly ionized blueshifted absorption lines from H-like and He-like ions of iron (and nickel), as well as of other elements (O, Ne, Si, and S) in the soft band. We confirm the presence of a persistent ultra-fast outflow (UFO) with a velocity of vout = −0.24 to −0.29 c, that has previously been detected. We also report the detection of an additional faster component of the UFO with a relativistic velocity of vout = −0.48 c. We implemented photoionization modeling, using XSTAR analytic model warmabs, to characterize the physical properties of the different kinematic components of the UFO and of the partially covering absorber detected in PDS 456. These two relativistic components of the UFO observed in the three epochs analyzed in this paper are powerful enough to impact the host galaxy of PDS 456 through feedback from active galactic nuclei.
Boron-Like Spectra: Mg viii, Al ix, and Si x

Ninety new line classifications and 70 new energy levels have been determined in the B i-like spectra, Mg viii, Al ix, and Si x. The results presented here extend the previous studies of Soderqvist and Ferner to the higher series members. Both doublet and quartet lines are observed but no intercombination lines were found. These lines lie between 30 and 70 A. For Si x, seven lines from 250 to 290 A, which have been previously seen in the sun, were measured to permit a more precise determination of the positions of the low-lying levels previously found.
EPR characterization of catalyst‐free SWNT and N@C60‐based peapods

Single Wall Carbon Nanotubes (SWNT) produced by “Super‐Growth” CVD technique show no evidence for non‐carbon impurities. At X‐Band frequencies an EPR signal from conduction electrons is observed at room temperature. At low temperatures the conduction electrons get trapped, leading to a sharp EPR signal with long‐lived spin states. Using multi pulse techniques the hyperfine interaction to 13C can be resolved. Using low temperature liquid phase filling techniques, it is possible to prepare N@C60@SWNT with filling efficiencies of a few percent. At elevated temperatures, the fullerenes show a quite mobile behavior, especially in SWNT of wide diameter. This motion continuously slows down at lower temperatures resulting in complete immobilization. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)