Miracle-dz/UniFAR-FTUs huggingface dataset:
A Framework for a Distributed and Adaptive Query Processing Engine for Wireless Sensor Networks

Wireless sensor networks (WSNs) are formed of tiny, highly energy-constrained sensor nodes that are equipped with wireless transceivers and can be used primarily in environmental monitoring applications. The nodes communicate with one another by autonomously creating ad-hoc multihop networks which are subsequently used to gather sensor data. WSNs also process the data within the network itself and only forward the result to the requesting node. This is referred to as in-network data aggregation and results in the substantial reduction of the amount of data that needs to be transmitted by any single node in the network. We present a framework for WSNs which would allow optimised query execution plans to be generated in a distributed manner using only locally available information within the network thus preventing the need to transmit network metadata all the way to a central server. We also describe how this framework can be used to perform cross-layer optimisations and illustrate this by presenting a MAC protocol that adapts its operation according to data gathered by the query processing engine. Query plans also adapt continuously by monitoring varying network conditions to maintain energy-efficient operation thus maximising network lifetime.
Austerity, privatization and levelling down: Public sector reforms in the United Kingdom

The United Kingdom is witnessing a prolonged economic depression. The level of GDP during the first quarter of 2012 was still 4 per cent lower than the prerecession peak recorded in early 20081 and it is expected that the period of recovery will be the longest of any crisis since the end of the First World War (NIESR 2011). Policy reforms designed to encourage a recovery of the economy came in the wake of the financial crash of 2008–09, but were in fact steered away from attempts at reforming the evident failures in the UK’s neoliberal model of financeled capitalism; a wideranging government review of banking (‘Project Merlin’) concluded by supporting the status quo, arguing against a reregulation of the industry and rejecting a tax on banks or on bonuses (King et al. 2012). Instead, in a context of an escalating sovereign debt crisis in Europe, a newly elected Conservativeled coalition government is arguing that economic recovery depends upon a radical reform of the state’s role in delivering public services in order both to reduce the structural deficit and to open up new opportunities for private sector investment and job growth. Both claims are hotly contested. As in other European countries, attempts at fiscal consolidation are backfiring: economic growth has stalled in the six quarters since the new government came to power; levels of employment and hours worked fell during 2011 (after a modest recovery in 2010); businesses report a sustained pessimistic outlook; and unemployment among men and women has increased further to new highs. The current public sector reforms have three characteristics: they impose a downwards quantitative adjustment in activity, involve transferring activity to the private sector and in several areas entail the ending of services provision. This chapter examines these characteristics (Section 3) and explores their consequences for employment, pay and pensions
Biodegradable Chitosan-Based Ambroxol Hydrochloride Microspheres: Effect of Cross-Linking Agents

The objective of this study was to investigate the influence of type of cross-linking method used on the properties of ambroxol hydrochloride microspheres such as encapsulation efficiency, particle size, and drug release. Microspheres were prepared by solvent evaporation technique using chitosan as a matrix-forming agent and cross-linked using formaldehyde and heat treatment. Morphological and physicochemical properties of microspheres were then investigated by scanning electron microscopy (SEM), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), and Fourier-transform infrared spectroscopy (FTIR) spectroscopy. The cross-linking of chitosan takes place at the free amino group because of formation of imine bond as evidenced by FTIR. The DSC, XRD, and FTIR analysis showed that chitosan microspheres cross linked by heating were superior in properties and performance as compared to the microspheres cross-linked using formaldehyde. SEM results revealed that heat-treated microspheres were spherical, discrete having smooth, and porous structure. The particle size and encapsulation efficiencies of the prepared chitosan microspheres ranged between 10.83-24.11 μm and 39.73-80.56%, respectively. The drug release was extended up to 12 h, and the kinetics of the drug release was obeying Higuchi kinetic proving diffusion-controlled drug release.
A Novel Insertion Variant of CRYGD Is Associated with Congenital Nuclear Cataract in a Chinese Family

Objective To investigate a novel insertion variant of CRYGD identified in a Chinese family with nuclear congenital cataract. Methods A Chinese family with congenital nuclear cataract was recruited for the mutational screening of candidate genes by direct sequencing. Recombinant N-terminal Myc tagged wildtype or mutant CRYGD was expressed in HEK293T cells. The expression pattern, protein solubility and subcellular distribution were analyzed by western blotting and immunofluorescence. Principal Findings A novel insertion variant, c. 451_452insGACT, in CRYGD was identified in the patients. It causes a frameshift and a premature termination of the polypeptide to become Y151*. A significantly reduced solubility was observed for this mutant. Unlike wildtype CRYGD, which existed mainly in the cytoplasm, Y151* was mis-located in the nucleus. Conclusions We have identified a novel mutation, c. 451_452insGACT, in CRYGD, which is associated with nuclear cataract. This is the first insertion mutation of CRYGD found to cause autosomal dominant congenital cataract. The mutant protein, with loss of solubility and localization to the nucleus, is hypothesized to be the major cause of cataract in these patients.
Detection of ATRX and IDH1-R132H immunohistochemistry in the progression of 211 paired gliomas

Recurrence and progression to higher grade lesions are key biological events and characteristic behaviors in the evolution process of glioma. A small residual population of cells always escapes surgery and chemoradiation, resulting in a typically fatal tumor recurrence or progression. IDH mutation (isocitrate dehydrogenase) and ATRX (alpha-thalassemia/mental retardation, X-linked) loss/mutation occur in association and may represent early genetic alterations in the development of gliomas. However, their prognostic value in the evolution of gliomas still needs further investigation. Two hundreds and eleven serial sampling of gliomas were included in our study. We used immunohistochemistry (IHC) to detect IDH1-R132H mutation and ATRX status and showed that the IDH1-R132H and (or) ATRX status could be necessary to provide the basic molecular information for the “integrated diagnosis” of gliomas. We illustrated an evaluation formula for the evolution of gliomas by IDH1-R132H combined with ATRX immunohistochemistry and identified the association of IDH1-R132H/ATRX loss accompanied by longer progression time interval of patients with gliomas. Furthermore, we observed that most recurrences had a consistent IDH1 and ATRX status with their matched primary tumors and demonstrated the progressive pattern of grade II astrocytoma/oligodendroglial tumors and anaplastic oligoastrocytoma with or without IDH1-R132H. Identification of IDH1-R132H and ATRX loss status in the primary-recurrent gliomas may aid in treatment strategy selection, therapeutic trial design, and clinical prognosis evaluation.
Biologia Plantarum Xx (x): Xxx-xxx, 20xx Comprehensive Analysis of Differently Expressed Genes and Proteins in Albino and Green Plantlets from a Wheat Anther Culture

The anther culture technique, although it has been widely used in wheat breeding programs, is associated with a high albinism rate that limits its application. The mechanism of albinism has not been studied explicitly at the molecular level. In this study, differently expressed genes (DEGs) and proteins (DEPs) of albino and green seedlings from a wheat anther culture were analyzed and compared using transcriptomic sequencing (RNA-Seq), two-dimensional electrophoresis, and mass spectrometry. For a total of 1 892 DEGs (1 115 down-regulated and 777 up-regulated) and 43 DEPs (15 down-regulated and 28 up-regulated) that are primarily involved in photosynthetic pathways and porphyrin and chlorophyll metabolism was identified when the albino group library was used as the control. Most DEGs participate in constructing components of thylakoids and the chloroplast envelope as determined via gene ontology analysis. The expression patterns of 12 selected genes were evaluated using real-time quantitative PCR, and the results were in agreement with the RNA-Seq analysis. Our results may assist the development of new methods to decrease the albino seedling rates in wheat anther cultures.
Synergistic Anti-Tumor Responses After Administration of Agonistic Antibodies to CD40 and IL-2: Coordination of Dendritic and CD8+ Cell Responses 1

In cancer, the coordinate engagement of professional APC and Ag-specific cell-mediated effector cells may be vital for the induction of effective antitumor responses. We speculated that the enhanced differentiation and function of dendritic cells through CD40 engagement combined with IL-2 administration to stimulate T cell expansion would act coordinately to enhance the adaptive immune response against cancer. In mice bearing orthotopic metastatic renal cell carcinoma, only the combination of an agonist Ab to CD40 and IL-2, but neither agent administered alone, induced complete regression of metastatic tumor and specific immunity to subsequent rechallenge in the majority of treated mice. The combination of anti-CD40 and IL-2 resulted in significant increases in dendritic cell and CD8+ T cell number in advanced tumor-bearing mice compared with either agent administered singly. The antitumor effects of anti-CD40 and IL-2 were found to be dependent on CD8+ T cells, IFN-γ, IL-12 p40, and Fas ligand. CD40 stimulation and IL-2 may therefore be of use to promote antitumor responses in advanced metastatic cancer.
Effect of colluding attack in collaborative spectrum sensing

Collaborative spectrum sensing (CSS) is an approach that enhances the spectrum sensing performance where multiple secondary users (SUs) cooperate to make the final sensing decision in a cognitive radio network (CRN). In CSS, the SUs are generally assumed to report correct local sensing result to the fusion center (FC). But, some SUs may be compromised and start reporting false local sensing decision to the FC to disrupt the network. CSS can also be severely affected by compromised nodes working together. Such a type of attack is termed as colluding attack and nodes that launch colluding attacks are known as colluding nodes. In this paper, we study the effect of colluding nodes in collaborative spectrum sensing. We also show that the presence of colluding attack results in higher as network performance degradation compared to independent attack especially when the presence of attackers is high. Hence, colluding attacks are of much security concern.
Transthyretin and BRICHOS: The Paradox of Amyloidogenic Proteins with Anti-Amyloidogenic Activity for Aβ in the Central Nervous System

Amyloid fibrils are physiologically insoluble biophysically specific β-sheet rich structures formed by the aggregation of misfolded proteins. In vivo tissue amyloid formation is responsible for more than 30 different disease states in humans and other mammals. One of these, Alzheimer's disease (AD), is the most common form of human dementia for which there is currently no definitive treatment. Amyloid fibril formation by the amyloid β-peptide (Aβ) is considered to be an underlying cause of AD, and strategies designed to reduce Aβ production and/or its toxic effects are being extensively investigated in both laboratory and clinical settings. Transthyretin (TTR) and proteins containing a BRICHOS domain are etiologically associated with specific amyloid diseases in the CNS and other organs. Nonetheless, it has been observed that TTR and BRICHOS structures are efficient inhibitors of Aβ fibril formation and toxicity in vitro and in vivo, raising the possibility that some amyloidogenic proteins, or their precursors, possess properties that may be harnessed for combating AD and other amyloidoses. Herein, we review properties of TTR and the BRICHOS domain and discuss how their abilities to interfere with amyloid formation may be employed in the development of novel treatments for AD.
Combined Authentication-Based Multilevel Access Control in Mobile Application for DailyLifeService

In current computing environments, collaborative computing has been a central concern in Ubiquitous, Convergent, and Social Computing. "MobiLife¿ and "MyLifeBits¿ are the leading projects for representing dailylifeservices and their systems require complicate and collaborative network systems. The collaborative computing environments remain in high potential risks for users' security and privacy because of diverse attack routes. In order to solve the problems, we design combined authentication and multilevel access control, which deals with cryptographic methods in a personal database of "MyLifeBits¿ system. We propose a scheme which is flexible in dynamic access authorization changes, secure against all the attacks from various routes, a minimum round of protocol, privacy preserving access control, and multifunctional.
Defining the mode, energetics and specificity with which a macrocyclic hexaoxazole binds to human telomeric G-quadruplex DNA

Oxazole-containing macrocycles represent a promising class of anticancer agents that target G-quadruplex DNA. We report the results of spectroscopic studies aimed at defining the mode, energetics and specificity with which a hexaoxazole-containing macrocycle (HXDV) binds to the intramolecular quadruplex formed by the human telomeric DNA model oligonucleotide d(T2AG3)4 in the presence of potassium ions. HXDV binds solely to the quadruplex nucleic acid form, but not to the duplex or triplex form. HXDV binds d(T2AG3)4 with a stoichiometry of two drug molecules per quadruplex, with these binding reactions being coupled to the destacking of adenine residues from the terminal G-tetrads. HXDV binding to d(T2AG3)4 does not alter the length of the quadruplex. These collective observations are indicative of a nonintercalative ‘terminal capping’ mode of interaction in which one HXDV molecule binds to each end of the quadruplex. The binding of HXDV to d(T2AG3)4 is entropy driven, with this entropic driving force reflecting contributions from favorable drug-induced alterations in the configurational entropy of the host quadruplex as well as in net hydration. The ‘terminal capping’ mode of binding revealed by our studies may prove to be a general feature of the interactions between oxazole-containing macrocyclic ligands (including telomestatin) and intramolecular DNA quadruplexes.
DESIGN PATTERNS FOR THE ONLINE NEWSPAPER GENRE

This thesis focuses on the role of design patterns in the design of the online newspaper genre. The research question put forth here is: How can design patterns be used to improve the online newspaper design process? Genre theory was applied to revile the structure and visual pattern of online newspaper design in an analysis of 85 Swedish online newspapers. Based on the results from the genre analysis, the concept of design patterns was used in forming basis for a common language for actors involved in designing online newspapers. This thesis provides a) a framework for understanding design characteristics of a specific digital genre, usable for generating design patterns b) a mapping of the design characteristics of the Swedish online newspapers c) a basis for a common design language, expressed in a template for design patterns based on genre characteristics for the online newspaper genre and d) a number of high level design patterns written specifically for front pages of online newspapers.
MINAT BERWIRAUSAHA MAHASISWA INDONESIA DAN CINA

Entrepreneurial intention, defined as a process of information-searching which can be used to achieve a new venture, has been intensively discussed as a contributed factor for those who intended to create a business. This study was purposed to explore predictors of entrepreneurial intention among Indonesian and Chinese students. We quantitavely integrated 241 students that have been used to investigated the relationship of the personality and environmental factors with entrepreneurial intention. As hypothesized, multiple regresson analysis and independent-sample t-test revealed the differences of entrepreneurial intention’s predictors among both countries. Chinese students were mostly affected by need for achievement, locus of control, self-efficacy, and instrumental readiness, while Indonesian students by self-efficacy. Implications toward university and government were discussed.
Thermal-aware lifetime reliability in multicore systems

As the power density of modern electronic circuits increases dramatically, systems are prone to overheating. High temperatures not only raise packaging costs, degrade system performance, and increase leakage power consumption, but also reduce the system reliability. Due to many limits in single core design including the performance and the power density, the microprocessor industry has switched their attentions to multicore design to enable the scaling of performance. Thermal effects on multicore systems are still prominent issues. One typical thermal effect is the thermal-aware lifetime reliability, which has become a serious concern. In this paper, we address the issue on how to maximize the lifetime of multicore systems while maintaining a given aggregate processor speed. By applying sequential quadratic programming, we present how to derive the ideal speed for each core to maximize the system lifetime. We perform experiments on several multi-core platforms, which show that the proposed method can significantly outperform the existing approaches by minimizing the peak temperature of the system.
SPECTRAL PROPERTIES OF REVERSIBLE ONE-DIMENSIONAL CELLULAR AUTOMATA

Reversible cellular automata are invertible dynamical systems characterized by discreteness, determinism and local interaction. This article studies the local behavior of reversible one-dimensional cellular automata by means of the spectral properties of their connectivity matrices. We use the transformation of every one-dimensional cellular automaton to another of neighborhood size 2 to generalize the results exposed in this paper. In particular we prove that the connectivity matrices have a single positive eigenvalue equal to 1; based on this result we also prove the idempotent behavior of these matrices. The significance of this property lies in the implementation of a matrix technique for detecting whether a one-dimensional cellular automaton is reversible or not. In particular, we present a procedure using the eigenvectors of these matrices to find the inverse rule of a given reversible one-dimensional cellular automaton. Finally illustrative examples are provided.
Beneficial Effects of Exercise Training in Patients with Chronic Heart Failure

Several human and experimental studies have been performed to show the effects of exercise training on chronic heart failure (CHF). These studies have shown that exercise improves the adverse pathophysiologic changes which occur with CHF, including enhanced exercise capacity, ventilation, skeletal muscle metabolism, cardiac function, quality of life, and peripheral blood flow. In addition, there is an improved modulation of inflammatory, autonomic, and hormonal dysregulation after exercise training. This review focuses on the current evidence surrounding the beneficial effects of exercise training in CHF patients.
Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects

Aging is associated with a decline in autophagy and a state of low-grade inflammation which further affects apoptosis and autophagy. Importantly, these alterations could reverse with regular physical activity. This study assessed the effects of a resistance exercise training program on autophagy, NLRP3 inflammasome, and apoptosis in peripheral blood mononuclear cells (PBMCs) from old subjects. Twenty-six healthy women and men (age, 69.6±1.5 yr) were randomized to a training (TG) or a control (CG) group. TG performed an 8-week resistance training program, while CG followed their daily routines. Protein expression of beclin-1, Atg12, Atg16 and LAMP-2 increased following the training program, while expression of p62/SQSTM1 and phosphorylation of ULK-1 at Ser757 were significantly lower. Resistance exercise also induced a decrease in NLRP3 expression and in the caspase-1/procaspase-1 ratio. Expression of Bcl-2 and Bcl-xL, as well as the Bad/BcL-2 ratio were reduced, and there was a significant decrease in the protein content of caspase-3. The results obtained seem to indicate that 8-week resistance training stimulates autophagy, prevents NLRP3 inflammasome activation, and reduces apoptosis in PBMCs from elderly subjects. These data could have a significant impact in prevention and rehabilitation programs currently employed in elderly population.
Learning the Genetic Causes for Schizophrenia through Copy-Number Variations

Schizophrenia is a mental disorder that causes lifelong disability. The most common symptoms are auditory hallucinations, paranoia, and delusions. At least 1% of Americans have this illness. [1] Factors that cause schizophrenia are both genetic and non-genetic. Research has shown that gene plays a significant role in schizophrenia through studies on twins. However, the genetic aberrations associated with schizophrenia have been hard to pin down. A large number of genome scan projects have reported linkage in three chromosomal regions, but none of these regions has produced strong support for linkage in the majority of the projects. [2] Unlike some diseases that can be caused by a single defective gene such as Huntington’s disease, schizophrenia is much more complex and elusive. [1, 3]
A HYBRID METHODOLOGY FOR OPTIMAL VAR DISPATCH IN THE WESTERN ALGERIAN POWER SYSTEM

This paper describes the methodology adopted for the optimal var dispatch (OVD) integrating a particle swarm optimization (PSO) algorithm and the interior point method (IPM). The proposed hybrid method can be mainly divided in two parts. The first part is to solve the OVD with the IPM based on the logarithmic- barrier primaldual algorithm (LB-PDA), for non linear programming (NLP) by relaxing the discrete variables. In the second part, the PSO algorithm is used to solve the discrete variables with the continuous variables being fixed, whereas the IPM solves the continuous optimization with the discrete variables being constant. The optimal solution can be obtained by solving the two sub-problems alternately. Numerical simulation on the Western Algerian power system illustrate this proposed hybrid method.