Miracle-dz/UniFAR-FTUs huggingface dataset:
Expanding the Molecular Spectrum of HK1-Related Charcot-Marie-Tooth Disease, Type 4G; the First Report in Iran

Charcot-Marie-Tooth disease type 4G (CMT4G) was first reported in Balkan Gypsies as a myelinopathy starting with progressive distal lower limb weakness, followed by upper limb involvement and prominent distal sensory impairment later in the patient’s life. So far, CMT4G has been only reported in European Roma communities with two founder homozygous variants; g.9712G>C and g.11027G>A, located in the 5’-UTR of the HK1 gene. Here, we present the first Iranian CMT4G patient manifesting progressive distal lower limb weakness from 11 years of age and diagnosed with chronic demyelinating sensorimotor polyneuropathy. Whole-exome sequencing for this patient revealed a homozygous c.19C>T (p. Arg7*) variant in the HK1 gene. This report expands the mutational spectrum of the HK1-related CMT disorder and provides supporting evidence for the observation of CMT4G outside the Roma population. Interestingly, the same Arg7* variant is recently observed in another unrelated Pakistani CMT patient, proposing a possible prevalence of this variant in the Middle Eastern populations.
FoilTrack: a package to increase strain-resolution by improved X-radiographic image processing

ABSTRACT In high pressure multi-anvil experiments X-radiography is used to ascertain strain in deforming samples because the tooling prevents optical or other direct observations of the sample. The processing of these X-radiographic images to determine bulk sample strain is one of the limiting factors to making measurements closer to the strains and strain-rates that occur during mantle convection or the passage of seismic waves. Typically, sample deformation in these experiments is tracked by the displacement of high-contrast marker foils in X-radiographs. X-radiographs are treated individually or pairwise in a multi-step process that tracks the displacement of marker foils during experiments. Here I develop a new algorithm, FoilTrack, that treats all the X-radiographic observations in a single-step process, resulting in improved accuracy and consistency of length changes determined from X-radiographic images, as well as providing more realistic parameter uncertainty. The improvements are demonstrated using data from small-strain sinusoidal deformation experiments.
Range–Visual–Inertial Odometry with Coarse-to-Fine Image Registration Fusion for UAV Localization

In Global Navigation Satellite System (GNSS)-denied environments, image registration has emerged as a prominent approach to utilize visual information for estimating the position of Unmanned Aerial Vehicles (UAVs). However, traditional image-registration-based localization methods encounter limitations, such as strong dependence on the prior initial position information. In this paper, we propose a systematic method for UAV geo-localization. In particular, an efficient range–visual–inertial odometry (RVIO) is proposed to provide local tracking, which utilizes measurements from a 1D Laser Range Finder (LRF) to suppress scale drift in the odometry. To overcome the differences in seasons, lighting conditions, and other factors between satellite and UAV images, we propose an image-registration-based geo-localization method in a coarse-to-fine manner that utilizes the powerful representation ability of Convolutional Neural Networks (CNNs). Furthermore, to ensure the accuracy of global optimization, we propose an adaptive weight assignment method based on the evaluation of the quality of image-registration-based localization. The proposed method is extensively evaluated in both synthetic and real-world environments. The results demonstrate that the proposed method achieves global drift-free estimation, enabling UAVs to accurately localize themselves in GNSS-denied environments.
GL-Pooling: Global–Local Pooling for Hyperspectral Image Classification

As an important structure in the convolutional neural network (CNN), the pooling layer can effectively reduce the generalization of the improved features after convolution. However, the current pooling method is easy to lose the key low-frequency small-sample data for the unbalanced hyperspectral image (HSI) data, which leads to a decrease in the classification accuracy for such data. In this letter, we propose a pooling method, global–local pooling (GL-pooling), for the target category of hyperspectral samples. Calculating the joint probability of samples in the global and local pooling and maximizing the retention of small-sample detail information in the pooling process to improve the detection efficiency of the network for small targets. Concomitantly, the pooling method can be widely combined in many deep learning (DL) networks to solve the problem of difficult classification of small-sample targets without increasing the network depth and the number of parameters. We achieve the best performance in two hyperspectral datasets.
A DFT Study of Volatile Organic Compounds Detection on Pristine and Pt-Decorated SnS Monolayers

Real-time monitoring of volatile organic compounds (VOCs) is crucial for both industrial production and daily life. However, the non-reactive nature of VOCs and their low concentrations pose a significant challenge for developing sensors. In this study, we investigated the adsorption behaviors of typical VOCs (C2H4, C2H6, and C6H6), on pristine and Pt-decorated SnS monolayers using density functional theory (DFT) calculations. Pristine SnS monolayers have limited charge transfer and long adsorption distances to VOC molecules, resulting in VOC insensitivity. The introduction of Pt atoms promotes charge transfer, creates new energy levels, and increases the overlap of the density of states, thereby enhancing electron excitation and improving gas sensitivity. Pt-decorated SnS monolayers exhibited high sensitivities of 241,921.7%, 35.7%, and 74.3% towards C2H4, C2H6, and C6H6, respectively. These values are 142,306.9, 23.8, and 82.6 times higher than those of pristine SnS monolayers, respectively. Moreover, the moderate adsorption energies of adsorbing C2H6 and C6H6 molecules ensure that Pt-decorated SnS monolayers possess good reversibility with a short recovery time at 298 K. When heated to 498 K, C2H4 molecules desorbs from the surface of Pt-decorated SnS monolayer in 162.33 s. Our results indicate that Pt-decorated SnS monolayers could be superior candidates for sensing VOCs with high selectivity, sensitivity, and reversibility.
Urban subsidence in rapid economic development: the case of Luoyang city, Henan Province

ABSTRACT Rapid urban development has led to severe land subsidence in Luoyang, Henan Province in the past few years. The current research on subsidence in urban areas of Luoyang is relatively few and early, and cannot reflect the current status of land subsidence in Luoyang. To grasp the current status of land subsidence in Luoyang and prevent the harm caused by subsidence. We used 57 Sentinel-1A Synthetic Aperture Radar (SAR) images covering Luoyang to obtain the land subsidence from April 2017 to December 2021 by using the small baseline subset interferometric SAR technique. The results show that there are several areas of land subsidence in Luoyang City, and the most serious area of subsidence is located near the highway in Jianxi District, with a cumulative subsidence of 130 mm. Land subsidence exists to varying degrees near transportation facilities (Expressway roads, railway, metro), key urban facilities (airports, high-speed railway stations) and ancient sites in Luoyang. A number of small-scale local subsidence in Luoyang is mainly related to high-intensity urban construction, and urban highway and building construction are the main causes of local land subsidence. Industrial activities are also an important factor in land subsidence in Luoyang. Groundwater and rainfall can impact land subsidence, and large amounts of rainfall during the flood season can replenish groundwater resources and slow down the rate of land subsidence. Loess foundations and large amounts of artificial fill in the city may also induce land subsidence.
The tailless gecko gets the worm: prey type alters the effects of caudal autotomy on prey capture and subjugation kinematics

Prey capture and subjugation are complex behaviors affected by many factors including physiological and behavioral traits of both the predator and the prey. The western banded gecko (Coleonyx variegatus) is a small generalist predator that consumes both evasive prey items, such as spiders, wasps, and orthopterans, and non-evasive prey items, including larvae, pupae, and isopterans. When consuming certain prey (e.g., scorpions), banded geckos will capture and then rapidly oscillate, or shake, their head and anterior part of their body. Banded geckos also have large, active tails that can account for over 20% of their body weight and can be voluntarily severed through the process of caudal autotomy. However, how autotomy influences prey capture behavior in geckos is poorly understood. Using high-speed 3D videography, we studied the effects of both prey type (mealworms and crickets) and tail autotomy on prey capture and subjugation performance in banded geckos. Performance metrics included maximum velocity and distance of prey capture, as well as velocity and frequency of post-capture shaking. Maximum velocity and distance of prey capture were lower for mealworms than crickets regardless of tail state. However, after autotomy, maximum velocity increased for strikes on mealworms but significantly decreased for crickets. After capture, geckos always shook mealworms, but never crickets. The frequency of shaking mealworms decreased after autotomy and additional qualitative differences were observed. Our results highlight the complex and interactive effects of prey type and caudal autotomy on prey capture biomechanics.
OZONE PRODUCTION IN THE PHILADELPHIA URBAN AREA DURING NE-OPS 99.

As part of the 1999 NARSTO Northeast Oxidant and Particulate Study (NE-OPS) field campaign, the DOE G-1 aircraft sampled trace gases and aerosols in and around the Philadelphia metropolitan area. Twenty research flights were conducted between July 25 and August 11. The overall goals of these flights were to obtain a mechanistic understanding of O{sub 3} production; to characterize the spatial and temporal behavior of photo-oxidants and aerosols; and to study the evolution of aerosol size distributions, including the process of new particle formation. Within the NE-OPS program, other groups provided additional trace gas, aerosol, and meteorological observations using aircraft, balloon, remote sensing, and surface based instruments (Phillbrick et al., 2000). In this article we provide an overview of the G-1 observations related to O{sub 3} production, focusing on the vertical distribution of pollutants. Ozone production rates are calculated using a box model that is constrained by observed trace gas concentrations. Highest O{sub 3} concentrations were observed on July 31, which we present as a case study. On that day, O{sub 3} concentrations above the 1-hour 120 ppb standard were observed downwind of Philadelphia and also in the plume of a single industrial facility located on the Delaware River south of the city.
A molecular framework for lc controlled locule development of the floral meristem in tomato

Malformed tomato fruit with multiple locules is a common physiological disorder that significantly affects the quality of tomatoes. Research has shown that the occurrence of malformed fruit in tomatoes is closely linked to the number of locules, and two key QTLs, lc and fas, are involved in controlling this trait. It has been observed that lc has a relatively weaker effect on increasing locule number, which is associated with two SNPs in the CArG repressor element downstream of the SlWUS. However, the precise molecular mechanism underlying lc is not yet fully understood. In this study, we investigated the role of lc in tomato locule development. We found that the number of floral organs and fruit locules significantly increased in tomato lc knockout mutants. Additionally, these mutants showed higher expression levels of the SlWUS during carpel formation. Through cDNA library construction and yeast one-hybrid screening, we identified the MADS-box transcription factor SlSEP3, which was found to bind to lc. Furthermore, we observed an increase in floral organs and fruit locules similar to the lc CR plant on SlSEP3 silencing plants. However, it should be noted that the lc site is located after the 3′ untranslated region (UTR) of SlWUS in the tomato genome. As a result, SlSEP3 may not be able to exert regulatory functions on the promoter of the gene like other transcription factors. In the yeast two-hybrid assay, we found that several histone deacetylases (SlHDA1, SlHDA3, SlHDA4, SlHDA5, SlHDA6, SlHDA7, and SlHDA8) can interact with SlSEP3. This indicated that SlSEP3 can recruit these proteins to repress nucleosome relaxation, thereby inhibiting SlWUS transcription and affecting the number of locules in tomato fruit. Therefore, our findings reveal a new mechanism for lc playing a significant role in the genetic pathway regulating tomato locule development.
Air-injection field tests to determine the effect of a heat cycle on the permeability of welded tuff

As part of a series of prototype tests conducted in preparation for site characterization of the potential nuclear-waste repository site at Yucca Mountain, Nevada, air-injection tests were conducted in the welded tuffs in G-Tunnel at the Nevada Test Site. The objectives were to characterize the permeability of the highly fractured tuff around a horizontal heater emplacement borehole, and to determine the effect of a heating and cooling cycle on the rock-mass permeability. Air was injected into packed-off intervals along the heater borehole. The bulk permeability of the rock adjacent to the test interval and the aperture of fractures intersecting the interval were computed from the air-flow rate, temperature, and pressure at steady state. The bulk permeability of intervals along with borehole varied from a minimum of 0.08 D to a maximum of over 144 D and the equivalent parallel-plate apertures of fractures intersecting the borehole varied from 70 to 589 {mu}m. Higher permeabilities seemed to correlate spatially with the mapped fractures. The rock was then heated for a period of 6.5 months with an electrical-resistive heater installed in the borehole. After heating, the rock was allowed to cool down to the ambient temperature. The highest borehole wall temperature measured wasmore » 242{degree}C. Air injection tests were repeated following the heating and cooling cycle, and the results showed significant increases in bulk permeability ranging from 10 to 1830% along the borehole. 8 ref. , 6 figs., 3 tabs. « less
Prospects of Using Chitosan-Based Biopolymers in the Treatment of Peripheral Nerve Injuries

Peripheral nerve injuries are common neurological disorders, and the available treatment options, such as conservative management and surgical repair, often yield limited results. However, there is growing interest in the potential of using chitosan-based biopolymers as a novel therapeutic approach to treating these injuries. Chitosan-based biopolymers possess unique characteristics, including biocompatibility, biodegradability, and the ability to stimulate cell proliferation, making them highly suitable for repairing nerve defects and promoting nerve regeneration and functional recovery. Furthermore, these biopolymers can be utilized in drug delivery systems to control the release of therapeutic agents and facilitate the growth of nerve cells. This comprehensive review focuses on the latest advancements in utilizing chitosan-based biopolymers for peripheral nerve regeneration. By harnessing the potential of chitosan-based biopolymers, we can pave the way for innovative treatment strategies that significantly improve the outcomes of peripheral nerve injury repair, offering renewed hope and better prospects for patients in need.
Acute exercise in a hot environment increases heat shock protein 70 and peroxisome proliferator-activated receptor γ coactivator 1α mRNA in Thoroughbred horse skeletal muscle

Heat acclimatization or acclimation training in horses is practiced to reduce physiological strain and improve exercise performance in the heat, which can involve metabolic improvement in skeletal muscle. However, there is limited information concerning the acute signaling responses of equine skeletal muscle after exercise in a hot environment. The purpose of this study was to investigate the hypothesis that exercise in hot conditions induces greater changes in heat shock proteins and mitochondrial-related signaling in equine skeletal muscle compared with exercise in cool conditions. Fifteen trained Thoroughbred horses [4.6 ± 0.4 (mean ± SE) years old; 503 ± 14 kg] were assigned to perform a treadmill exercise test in cool conditions [COOL; Wet Bulb Globe Temperature (WBGT), 12.5°C; n = 8] or hot conditions (HOT; WBGT, 29.5°C; n = 7) consisting of walking at 1.7 m/s for 1 min, trotting at 4 m/s for 5 min, and cantering at 7 m/s for 2 min and at 90% of VO2max for 2 min, followed by walking at 1.7 m/s for 20 min. Heart rate during exercise and plasma lactate concentration immediately after exercise were measured. Biopsy samples were obtained from the middle gluteal muscle before and at 4 h after exercise, and relative quantitative analysis of mRNA expression using real-time RT-PCR was performed. Data were analyzed with using mixed models. There were no significant differences between the two groups in peak heart rate (COOL, 213 ± 3 bpm; HOT, 214 ± 4 bpm; p = 0.782) and plasma lactate concentration (COOL, 13.1 ± 1.4 mmoL/L; HOT, 17.5 ± 1.7 mmoL/L; p = 0.060), while HSP-70 (COOL, 1.9-fold, p = 0.207; HOT, 2.4-fold, p = 0.045), PGC-1α (COOL, 3.8-fold, p = 0.424; HOT, 8.4-fold, p = 0.010), HIF-1α (COOL, 1.6-fold, p = 0.315; HOT, 2.2-fold, p = 0.018) and PDK4 (COOL, 7.6-fold, p = 0.412; HOT, 14.1-fold, p = 0.047) mRNA increased significantly only in HOT at 4 h after exercise. These data indicate that acute exercise in a hot environment facilitates protective response to heat stress (HSP-70), mitochondrial biogenesis (PGC-1α and HIF-1α) and fatty acid oxidation (PDK4).
Antagonistic activity of lactic acid bacteria isolated from Minas artisanal cheeses against Brucella abortus

This study aimed to evaluate methods for studying the in vitro antimicrobial activity of lactic acid bacteria (LAB) against Brucella abortus and to evaluate the antagonistic effect of LAB on the viability of this pathogen. A total of 18 LAB strains (Lactobacillus plantarum, n = 11; Pediococcus acidilactici, n = 1; Lactobacillus rhamnosus, n = 4; and Lactobacillus brevis, n = 2), isolated from Minas artisanal cheeses produced in three regions (Canastra, Campos das Vertentes, and Araxá) of Minas Gerais State, Brazil, were tested for their antimicrobial activity against B. abortus using three methods: spot-on-lawn, agar well diffusion assay, and antagonistic activity of the culture supernatants. None of the tested LAB strains could inhibit B. abortus in the spot-on-lawn and agar-well diffusion assays. The supernatants produced by LAB had an acidic pH, with intensity depending on bacterial growth and strain, and could inhibit the growth of B. abortus. In contrast, pH-neutralized (pH 7.0) LAB supernatants did not suppress the growth of B. abortus. The results showed that the best technique to study the in vitro antagonism of LAB against B. abortus was the antagonistic activity of culture supernatants. The growth of B. abortus may have been inhibited by acid production.
Democratic Public Service (Case of License Operating Billboards in Makassar City)

One of the points of concern in public administration is the organising of democratic public services. Democratic public service is the basic essence in realizing justice and social welfare. This can be realized if it involves all state stakeholders and domains in the administration of the government. In this perspective, public services should obtain genuine attention, be processed professionally and properly provided to residents of service users. Billboard licence is one of the types of licensing services issued by the government along with the rapid growth of companies or industries that have an impact on the increase in regional revenue. In addition to increasing regional revenue, the increase in billboards is directly proportional to various violations that occur because of services provided so that they are important to be handled. The purpose of this study is to evaluate the degree to which the Regional Revenue Agency of Makassar City, one of the government organisers in public services, organises democratic public services, particularly in the execution of billboards. The study employs a qualitative method and includes both primary and secondary data. Through in-depth interviews and observation, primary data is gathered. secondary information obtained from documents. Data reduction is then used to process the acquired data. The results of the study show that democratic public services have not been implemented. Complexity, bureaucracy, apparatus performance and community attitudes towards public services are factors that influence service integrity.
A 113.3-dB Dynamic Range 600 Frames/s SPAD X-Ray Detector With Seamless Global Shutter and Time-Encoded Extrapolation Counter

This article presents a <inline-formula> <tex-math notation="LaTeX">$400 \times 200$ </tex-math></inline-formula> single-photon avalanche diode (SPAD) X-ray detector that supports seamless global shutter operation. The pixel consists of an SPAD with two time-encoded extrapolation counters. For use under low X-ray dose conditions, the pixels and readout circuitry operate in a fully digital manner, avoiding the noise penalty of the readout. Under high X-ray dose conditions, the proposed counter operates in the extrapolation mode and thus achieves a high dynamic range (HDR), while reducing the counter’s power consumption. This is achieved by capturing the time of the counter overflow (<inline-formula> <tex-math notation="LaTeX">$T_{\mathrm{ OF}}$ </tex-math></inline-formula>) and expanding the counter depth by the ratio between the integration time (<inline-formula> <tex-math notation="LaTeX">$T_{\mathrm{ INT}}$ </tex-math></inline-formula>) and <inline-formula> <tex-math notation="LaTeX">$T_{\mathrm{ OF}}$ </tex-math></inline-formula>. To reconstruct <inline-formula> <tex-math notation="LaTeX">$T_{\mathrm{ OF}}$ </tex-math></inline-formula>, a <inline-formula> <tex-math notation="LaTeX">$\phi _{\mathrm{ GCLK}}$ </tex-math></inline-formula> signal is distributed during <inline-formula> <tex-math notation="LaTeX">$T_{\mathrm{ INT}}$ </tex-math></inline-formula> and accumulated from <inline-formula> <tex-math notation="LaTeX">$T_{\mathrm{ OF}}$ </tex-math></inline-formula> to the end of <inline-formula> <tex-math notation="LaTeX">$T_{\mathrm{ INT}}$ </tex-math></inline-formula> by reusing the counter. This only requires distribution of the <inline-formula> <tex-math notation="LaTeX">$\phi _{\mathrm{ GCLK}}$ </tex-math></inline-formula> across the pixel array. Furthermore, seamless global shutter operation is realized through the use of two counters, which achieves a 100% temporal aperture for the X-ray photon. The proposed X-ray detector is implemented in a 1P5M 65-nm CMOS process. To be used for both medical diagnosis and industrial inspection, the pixel pitch is selected as 49.5 <inline-formula> <tex-math notation="LaTeX">$\mu \text {m}$ </tex-math></inline-formula>. The <inline-formula> <tex-math notation="LaTeX">$400 \times 200$ </tex-math></inline-formula> detector achieves a dynamic range (DR) of 113.3 dB, while consuming only 127.2 mW. Compared with previous X-ray detectors, the proposed detector exhibits a 24.9-dB improvement in DR.