Miracle-dz/UniFAR-FTUs huggingface dataset:
Pro370Leu mutant myocilin impairs mitochondrial functions in human trabecular meshwork cells

Purpose Oxidative stress is a risk factor for the onset and progression of primary open-angle glaucoma (POAG), but the exact molecular basis remains unknown. Here, we investigated the mechanisms for Pro370Leu mutant myocilin to induce mitochondrial dysfunction and subsequent reactive oxygen species (ROS) generation in trabecular meshwork (TM) cells obtained from POAG individuals. Methods Primary non-diseased human TM cultures were transfected with pIRES-EGFP (Mock), pIRES-wild-type (WT), or pIRES-Pro370Leu mutant myocilin. Transfection efficiency and myocilin subcellular localization were determined by polymerase chain reaction (PCR), western blot analysis, and confocal microscopy. ROS levels as well as free Ca2+ concentrations in cytoplasm ([Ca2+]c) and mitochondria ([Ca2+]m) were examined by 2’7’-dichlorofluorescein diacetate (H2-DCF-DA), Fluo-3 acetoxymethyl ester (Fluo-3/AM), and Rhod-2 acetoxymethyl ester (rhod-2/AM), respectively, using flow cytometry. Mitochondrial functions were revealed by changes in mitochondrial membrane potential (ΔΨm) and ATP production, which were found by fluorescent probe 5,5′,6,6’-tetrachloro-1,1’3,3′-tetraethylbenzimid azolocarbocyanine iodide (JC-1) and a luciferin/luciferase-based ATP assay, respectively. Results Both WT and Pro370Leu mutant myocilin are localized in the mitochondria of TM cells as indicated using confocal microscopy and western blot analysis. Overexpression of WT myocilin decreases ΔΨm, which is further reduced by Pro370Leu mutant myocilin. TM cells that overexpressed Pro370Leu mutant myocilin have greater cell death, higher endogenous ROS, [Ca2+]c, and [Ca2+]m levels, and lower ATP production, and yet, these effects are not seen in the overexpression of WT myocilin. Conclusions Our findings suggested that Pro370Leu mutant myocilin causes mitochondrial defects, which may lead to TM cell dysfunction and even cell death. Therefore, preventive measures targeting mitochondrial protection may delay the onset of glaucoma in individuals carrying the Pro370Leu myocilin mutation.
Ultra-Dense LEO: Integration of Satellite Access Networks into 5G and Beyond

To support the explosive growth of wireless devices and applications, various access techniques need to be developed for future wireless systems to provide reliable data services in vast areas. With recent significant advances in ultra-dense low Earth orbit (LEO) satellite constellations, satellite access networks (SANs) have shown their significant potential to integrate with 5G and beyond to support ubiquitous global wireless access. In this article, we propose an enabling network architecture for dense LEO-SANs in which the terrestrial and satellite communications are integrated to offer more reliable and flexible access. Through various physical-layer techniques such as effective interference management, diversity techniques, and cognitive radio schemes, the proposed SAN architecture can provide seamless and high-rate wireless links for wireless devices with different quality of service requirements. Three extensive applications and some future research directions in both the physical layer and network layer are then discussed.
Automatically Face Detection and Recognition System Based on Principal Component Analysis ( PCA ) with Back Propagation Neural Networks ( BPNN )

Face recognition has received substantial attention from researches in biometrics, pattern recognition field and computer vision communities. Face recognition can be applied in Security measure at Air ports, Passport verification, Criminals list verification in police department, Visa processing , Verification of Electoral identification and Card Security measure at ATM’s. In this paper, a face recognition system for personal identification and verification using Principal Component Analysis (PCA) with Back Propagation Neural Networks (BPNN) is proposed. This system consists on three basic parts, first: the Face Detection partwhich automatically detect human face image using BPNN, second: the various facial features extraction, and the third: face recognition are performed based on Principal Component Analysis (PCA) with BPNN. The dimensionality of face image is reduced by the PCA and the recognition is done by the BPNN for efficient and robust face recognition. This paper also focuses the face database with different sources of variations, especially pose, expression, accessories, lighting and bacgrounds would be used to advance the state-of-the-art face recognition technologies aiming at practical applications
The NIH genetic testing registry: a new, centralized database of genetic tests to enable access to comprehensive information and improve transparency

The National Institutes of Health Genetic Testing Registry (GTR; available online at http://www.ncbi.nlm.nih.gov/gtr/) maintains comprehensive information about testing offered worldwide for disorders with a genetic basis. Information is voluntarily submitted by test providers. The database provides details of each test (e.g. its purpose, target populations, methods, what it measures, analytical validity, clinical validity, clinical utility, ordering information) and laboratory (e.g. location, contact information, certifications and licenses). Each test is assigned a stable identifier of the format GTR000000000, which is versioned when the submitter updates information. Data submitted by test providers are integrated with basic information maintained in National Center for Biotechnology Information’s databases and presented on the web and through FTP (ftp.ncbi.nih.gov/pub/GTR/_README.html).
Polymeric Hydrogels as Technology Platform for Drug Delivery Applications

Hydrogels have become key players in the field of drug delivery owing to their great versatility in terms of composition and adjustability to various administration routes, from parenteral (e.g., intravenous) to non-parenteral (e.g., oral, topical) ones. In addition, based on the envisioned application, the design of bioadhesive or mucoadhesive hydrogels with prolonged residence time in the administration site may be beneficial. For example, hydrogels are used as wound dressings and patches for local and systemic therapy. In a similar way, they can be applied in the vaginal tract for local treatment or in the nasal cavity for a similar goal or, conversely, to target the central nervous system by the nose-to-brain pathway. Overall, hydrogels have demonstrated outstanding capabilities to ensure patient compliance, while achieving long-term therapeutic effects. The present work overviews the most relevant and recent applications of hydrogels in drug delivery with special emphasis on mucosal routes.
Enhancing Online Problems Through Instructor-Centered Tools for Randomized Experiments

Digital educational resources could enable the use of randomized experiments to answer pedagogical questions that instructors care about, taking academic research out of the laboratory and into the classroom. We take an instructor-centered approach to designing tools for experimentation that lower the barriers for instructors to conduct experiments. We explore this approach through DynamicProblem, a proof-of-concept system for experimentation on components of digital problems, which provides interfaces for authoring of experiments on explanations, hints, feedback messages, and learning tips. To rapidly turn data from experiments into practical improvements, the system uses an interpretable machine learning algorithm to analyze students' ratings of which conditions are helpful, and present conditions to future students in proportion to the evidence they are higher rated. We evaluated the system by collaboratively deploying experiments in the courses of three mathematics instructors. They reported benefits in reflecting on their pedagogy, and having a new method for improving online problems for future students.
Nutritional Strategies Facing an Older Demographic: The Nutrition UP 65 Study Protocol

Background The population of Portugal is aging. The lack of data on older adults’ nutritional status and the lack of nutrition knowledge amongst health professionals, caregivers, and older adults themselves, remains a challenge. Objective The Nutrition UP 65 study aims to reduce nutritional inequalities in the older Portuguese adult population and improve knowledge regarding older Portuguese adults’ nutritional status, specifically relating to undernutrition, obesity, sarcopenia, frailty, hydration, sodium, and vitamin D statuses. Methods A representative sample of older Portuguese adults was selected. Sociodemographic, lifestyle, anthropometric, functional, and clinical data were collected. Sodium excretion, hydration, and vitamin D statuses were assessed. Results Data collection (n=1500) took place between December, 2015 and June, 2016. Results will be disseminated in national and international scientific journals, and via Portuguese media. Conclusions Nutrition UP 65 results will provide evidence for the design and implementation of effective preventive public health strategies regarding the elderly. These insights may represent relevant health gains and costs savings.
Contradiction-Tolerant Process Algebra with Propositional Signals

In a previous paper, an ACP-style process algebra was proposed in which propositions are used as the visible part of the state of processes and as state conditions under which processes may proceed. This process algebra, called ACPps, is built on classical propositional logic. In this paper, we present a version of ACPps built on a paraconsistent propositional logic which is essentially the same as CLuNs. There are many systems that would have to deal with self-contradictory states if no special measures were taken. For a number of these systems, it is conceivable that accepting self-contradictory states and dealing with them in a way based on a paraconsistent logic is an alternative to taking special measures. The presented version of ACPps can be suited for the description and analysis of systems that deal with self-contradictory states in a way based on the above-mentioned paraconsistent logic.
An Improved Analysis for Support Recovery With Orthogonal Matching Pursuit Under General Perturbations

Orthogonal matching pursuit (OMP) is a widely used greedy algorithm for recovering the support of a sparse signal x from the underdetermined model <inline-formula> <tex-math notation="LaTeX">$\text {y}=\text {A}\text {x}$ </tex-math></inline-formula>. In practice, we should analyze the performance of OMP under general perturbations, which means that both y and A are perturbed. In this paper, under general perturbations, we present necessary and sufficient conditions for the exact support recovery with the OMP. We also discuss the performance of OMP for recovering <inline-formula> <tex-math notation="LaTeX">$\alpha $ </tex-math></inline-formula> strongly decaying sparse signals. Typically, in the noise-free case, we show that the upper bound of our sufficient condition is unrelated with <inline-formula> <tex-math notation="LaTeX">$K$ </tex-math></inline-formula> and is a sharp bound. Furthermore, we establish sufficient conditions for the recovery of OMP, which can guarantee that the recovery is in the order of the signal entries’ magnitude.
Wireless video transmission using multiple description codes combined with prioritized DCT compression

In this paper, we provide a new scheme for transmission of video information over wireless channels. This scheme is constructed by combining the prioritized discrete cosine transform (DCT) for video compression with multiple description codes based on forward error correction (FEC) codes. Reed-Solomon codes with different error correction abilities are applied to different parts of the progressive source bitstream, and finally these blocks are split into several equal descriptions for transmission. The prioritized DCT coder gives a wonderful progressive feature with less complexity and can be easily combined with the FEC based multiple description generation. We demonstrate via simulation that this scheme can improve the robustness of video transmission over wireless channels and allow video quality to degrade gracefully as channel conditions worsen.
Molecular Progress in Research on Fruit Astringency

Astringency is one of the most important components of fruit oral sensory quality. Astringency mainly comes from tannins and other polyphenolic compounds and causes the drying, roughening and puckering of the mouth epithelia attributed to the interaction between tannins and salivary proteins. There is growing interest in the study of fruit astringency because of the healthy properties of astringent substances found in fruit, including antibacterial, antiviral, anti-inflammatory, antioxidant, anticarcinogenic, antiallergenic, hepatoprotective, vasodilating and antithrombotic activities. This review will focus mainly on the relationship between tannin structure and the astringency sensation as well as the biosynthetic pathways of astringent substances in fruit and their regulatory mechanisms.
Graph-based mobility model for mobile ad hoc network simulation

Imagine a world where people constantly try to pass through walls and cars suddenly leave the roads and drive into rivers. Although this is unrealistic, most simulations for mobile ad hoc networks so far are based on the so called "random walk" of mobile objects, which are not constrained by their surrounding spatial environments. In this paper we propose a novel graph-based mobility model, which provides a more realistic movement than the random walk model by reflecting the spatial constraints in the real world. We analyzed three commonly used ad hoc network routing protocols, DSDV, DSR and AODV with both a random walk-based and our graph-based mobility model. Our simulation results show that the spatial constraints have a strong impact on the performance of ad hoc routing protocols.
Active Electrode Redox Reactions and Device Behavior in ECM Type Resistive Switching Memories

Electrochemical metallization cells rely on oxidation, reduction, and migration of metal cations in nanoscale thin films. The cations are typically provided by the oxidation of the active electrode. Commonly, Cu, Ag, or their compounds are used as electrodes for injecting cations into solid electrolytes, such as Ta2O5 or SiO2. However, the used criteria are mainly based on empirical knowledge. In this work, different materials (Ag, Al, Au, Cu, Fe, Ni, Ta, Ti, V, and Zr) are investigated for active electrodes and their redox reactions are studied. It is found that the electrochemical behavior of the metals is crucial for the switching properties, as well as for filament stability and retention properties of the devices. The Gibbs free energy of formation of the cations is identified as crucial factor for selection criteria.
Cor pulmonale as a result of chronic nasopharyngeal obstruction due to hypertrophied tonsils and adenoids.

It is important to recognize that heart failure in young children can be due to causes other than congenital heart disease. A syndrome has recently been recognized in children which can lead to gross cardiac failure and yet can apparently be permanently cured simply by removing the tonsils and adenoids. It is the syndrome of cor pulmonale due to hypoventilation resulting from chronic nasopharyngeal obstruction. Since the first reports (Menashe, Farrehi, and Miller, 1965; Noonan, 1965) others have appeared, bringing the total of reported cases to 16 (Luke et al., 1966; Levy et al., 1967; Ainger, 1968). We present here the clinical, electrocardiographic, and radiological findings in 3 patients, together with the results of cardiac catheterization in 2 of them.
Conductive biomaterials in cardiac tissue engineering

Conductive biomaterials (including conductive polymer, carbon-base materials, nanogold, and conductive silicon nanowires etc.) with prominent electrical conductivity, good cellular response, and promotion of cell-cell signaling transduction are possibly more suitable for cardiac tissue engineering. To date, their excellent properties catch more attention of the researchers to investigate their roles in life science research. Due to the limited therapeutic approaches of myocardial infarction (MI), engineered cardiac patches have received more attention in the treatment of MI. While, conductive biomaterial taken as a scaffold for cardiac tissue engineering is a promising strategy to repair infarct myocardium and improve the cardiac function. In this review, we summarized the fabrication of various conductive biomaterials for cardiac tissue engineering, and discuss the interaction between the conductive biomaterials and the cells [cardiomyocytes (CMs) and stem cells]. The advance of conductive biomaterials in tissue engineering, regenerative medicine and bio-sensing are also demonstrated.
Pancreatic neuropathy and neuropathic pain--a comprehensive pathomorphological study of 546 cases.

BACKGROUND & AIMS Chronic pancreatitis (CP) and pancreatic adenocarcinoma (PCa) are characterized by intrapancreatic neural alterations and pain. Our aims were to: (a) Investigate whether neuropathic changes like pancreatic neuritis, increased neural density, and hypertrophy are phenomena only in CP or whether they are also evident in other pancreatic disorders as well, (b) study possible variations in neural cancer cell invasion among malignant pancreatic tumors, and (c) explore whether these neuropathic changes contribute to pain sensation. METHODS Neuropathic changes were studied in PCa (n=149), in CP (n=141), in pancreatic tumors (PTm) including serous/mucinous cystadenomas, invasive/noninvasive intraductal papillary mucinous neoplasias, benign/malignant neuroendocrine tumors, ampullary cancers (n=196), and in normal pancreas (n=60). The results were correlated with GAP-43 expression, tissue inflammation, pancreatic neuritis, neural invasion, fibrosis, desmoplasia, pain, and patient survival. RESULTS Increased neural density and hypertrophy were only detected in PCa and CP and were strongly associated with GAP-43 over expression and abdominal pain. The severity of pancreatic neuritis was strongest in PCa and was closely linked to changes in neural density and hypertrophy. The aggressiveness of neural cancer cell invasion was most prominent in PCa and was related to neuropathic changes, desmoplasia, and pain. Severe and enduring pain were strongly associated with poor prognosis in PCa patients. CONCLUSIONS Enhanced neural density and hypertrophy are only typical features of CP and PCa among all investigated pancreatic disorders. Such neuropathic changes, including damage to nerves by inflammatory and/or cancer cells, seem to enhance and generate pancreatic neuropathic pain.
Effect of friction stir processing and hybrid reinforcements on copper

ABSTRACT In this research, a copper based surface composite was fabricated through dispersing hybrid composite particles onto its surface through friction stir processing (FSP) technique. Optical micrographs and scanning electron microscopy images indicates finer refinement of grains and particles dispersion into matrix along with its bonding and particle separation. As per the outcomes of microhardness analysis, hardness of the developed surface composite shows increment with increase in dispersion of volume fraction of hybrid particles. Strength of the developed copper surface composite exhibited a positive trend with introduction of hybrid reinforcement particle onto the surface of the composite but yet again ductility reduced. Wear resistance of the composite increased with reinforcement addition and the same was supported through worn out surface morphology. Fluctuations in friction coefficient value reduced with increase in particles, as for the presence in BN particles while the average frictional coefficient value was observed increasing. A reduction in corrosion rate was observed with increase in reinforcement particle dispersion onto copper matrix through FSP.
Are They Different? Affect, Feeling, Emotion, Sentiment, and Opinion Detection in Text

A major limitation in the automatic detection of affect, feelings, emotions, sentiments, and opinions in text is the lack of proper differentiation between these subjective terms and understanding of how they relate to one another. This lack of differentiation not only leads to inconsistency in terminology usage but also makes the subtleties and nuances expressed by the five terms difficult to understand, resulting in subpar detection of the terms in text. In light of such limitation, this paper clarifies the differences between these five subjective terms and reveals significant concepts to the computational linguistics community for their effective detection and processing in text.
Probiotics in Asthma and Allergy Prevention

Interest in probiotic research and its potential benefits in infant foods are relatively recent but significantly increasing. The evolution of the knowledge in the last 20 years demonstrated that alterations in the microbiome may be a consequence of events occurring during infancy or childhood, including prematurity, cesarean section, and nosocomial infections. Several pieces of evidence prove that a “healthy” intestinal microbiota facilitates the development of immune tolerance. Interventional studies suggest that probiotics could be protective against the development of many diseases. Nevertheless, many factors complicate the analysis of dysbiosis in subjects with food allergy. Comparison in-between studies are difficult, because of considerable heterogeneity in study design, sample size, age at fecal collection, methods of analysis of gut microbiome, and geographic location. Currently, there is no positive recommendation from scientific societies to use pre- or probiotics for treatment of food allergy or other allergic manifestations, while their use in prevention is being custom-cleared. However, the recommendation is still based on little evidence. Although there is valid scientific evidence in vitro, there is no sufficient information to suggest the use of specific probiotics in allergy and asthma prevention.
Penentuan Kadar dan Distribusi Spasial Logam Berat Kadmium (Cd) pada Rumput Laut Euchema cottonii Asal Perairan Kab. Takalar dengan Metode Spektrofotometer Serapan Atom (SSA)

Seaweed is one of the potential export commodity to be developed in Indonesia. Types of seaweed in Indonesia that have high economic value, namely Eucheuma cottonni where Takalar is one seaweed production center in South Sulawesi. This study aimed to determine the levels of heavy metal cadmium in seawater and seaweed and the distribution of heavy metals in the waters of Takalar. The cadmium quality kwelswere determined by Atomic Absorption spectrophotometry (AAS) method. The sample analysis did through the process of destruction used HNO3, 10% HCl. The total spots of sampling are six in ekuding Sanrobone, Maciini Baji, Batiro Baji, Laikang and Puntondo village were spreaded out from North to South. The results of research shaowed that Cd metal was distributed at six site where the highest level was on Sanrobone village that was 0.4725 ppm and the lowest in Puntondo village that was 0.3910 ppm. The high levels of cadmium was influenced by levels of Cd on the sea water where the highest level of Cadmium were in the Sanrobone village and the lowest level in the Puntondo village. The levels of Cadmium metal on sea and Euchema cottonii seaweed at six has exceded the threshold set by PP RI No.20/1990 was 0,1 ppm.