Miracle-dz/UniFAR-FTUs huggingface dataset:
Cardiac Autonomic Function, Cardiovascular Risk and Physical Activity in Adolescents

Abstract The aims of this study were to investigate in adolescents: 1) the relationships of physical activity (PA) and cardiorespiratory fitness (CRF) to traditional CVD risk factors, rest and recovery autonomic function; and 2) whether autonomic function strengthens the associations between PA, CRF and CVD risk. Fifty-four (22 girls) adolescents had traditional CVD risk factors, rest and recovery autonomic function evaluated. CRF was measured using a steep ramp cycle test and PA was assessed with accelerometers. Resting HRV (and RMSSD30) and heart rate recovery (T30, HHRτ) were used. Clustered traditional (CVDRtrad) and autonomic (CVDRauto) risk scores were created and added to form a composite clustered CVD risk score (CVDRcom). PA and CRF were significantly and negatively associated with traditional CVD risk factors. Moderate (MPA) and vigorous (VPA) were positively related to resting RMSSD, and negatively related to T30 and HHRτ (all P<0.05). RMSSD30 recovered faster in the high compared to low median split for VPA. Stronger associations for CVDRcom compared to CVDRtrad were observed for MPA (CVDRcom: r2=0.32, P=<0.001; CVDRtrad: r2=0.17, P=0.002), and VPA (CVDRcom: r2=0.18, P=0.001; CVDRtrad: r2=0.06, P=0.08). These findings strengthen the proposed additional beneficial effects of PA on autonomic function above traditional CVD risk factors.
Control-Related Motivations and Information Security Policy Compliance: The Role of Autonomy and Efficacy

Abstract Employees' failures to follow information security policy can be costly to organizations, causing organizations to implement security controls to motivate secure behavior. Information security research has explored many control-related motivations (e.g., self-efficacy, response efficacy, and behavioral control) in the context of ISP compliance; however, the behavioral effects of perceptions of autonomous functioning are not well understood in security contexts. This paper examines employee autonomy as a control-related motivation from the lens of self-determination theory and psychological reactance theory. Self-determination theory is widely used in other disciplines to explain intrinsically driven behavior, but has not been applied to security research. Psychological reactance theory is also widely used, but is only beginning to receive attention in security research. Self-determination and psychological reactance offer complementary yet opposite conceptualizations of trait-based autonomy. This paper posits that perceptions of trait-based autonomy influence self-efficacy and response efficacy. Through a survey of government employees, we provide support for several hypotheses. We also discuss important directions for the use of self-determination theory and psychological reactance theory in future research.
The C-Terminal Region of Eukaryotic Translation Initiation Factor 3a (eIF3a) Promotes mRNA Recruitment, Scanning, and, Together with eIF3j and the eIF3b RNA Recognition Motif, Selection of AUG Start Codons

ABSTRACT The C-terminal domain (CTD) of the a/Tif32 subunit of budding yeast eukaryotic translation initiation factor 3 (eIF3) interacts with eIF3 subunits j/Hcr1 and b/Prt1 and can bind helices 16 to 18 of 18S rRNA, suggesting proximity to the mRNA entry channel of the 40S subunit. We have identified substitutions in the conserved Lys-Glu-Arg-Arg (KERR) motif and in residues of the nearby box6 element of the a/Tif32 CTD that impair mRNA recruitment by 43S preinitiation complexes (PICs) and confer phenotypes indicating defects in scanning and start codon recognition. The normally dispensable CTD of j/Hcr1 is required for its binding to a/Tif32 and to mitigate the growth defects of these a/Tif32 mutants, indicating physical and functional interactions between these two domains. The a/Tif32 CTD and the j/Hcr1 N-terminal domain (NTD) also interact with the RNA recognition motif (RRM) in b/Prt1, and mutations in both subunits that disrupt their interactions with the RRM increase leaky scanning of an AUG codon. These results, and our demonstration that the extreme CTD of a/Tif32 binds to Rps2 and Rps3, lead us to propose that the a/Tif32 CTD directly stabilizes 43S subunit-mRNA interaction and that the b/Prt1-RRM-j/Hcr1-a/Tif32-CTD module binds near the mRNA entry channel and regulates the transition between scanning-conducive and initiation-competent conformations of the PIC.
In vitro evolution of chemically-modified nucleic acid aptamers: Pros and cons, and comprehensive selection strategies

ABSTRACT Nucleic acid aptamers are single-stranded DNA or RNA oligonucleotide sequences that bind to a specific target molecule with high affinity and specificity through their ability to adopt 3-dimensional structure in solution. Aptamers have huge potential as targeted therapeutics, diagnostics, delivery agents and as biosensors. However, aptamers composed of natural nucleotide monomers are quickly degraded in vivo and show poor pharmacodynamic properties. To overcome this, chemically-modified nucleic acid aptamers are developed by incorporating modified nucleotides after or during the selection process by Systematic Evolution of Ligands by EXponential enrichment (SELEX). This review will discuss the development of chemically-modified aptamers and provide the pros and cons, and new insights on in vitro aptamer selection strategies by using chemically-modified nucleic acid libraries.
BGLF2 Increases Infectivity of Epstein-Barr Virus by Activating AP-1 upon De Novo Infection

Epstein-Barr virus (EBV), an oncogenic gammaherpesvirus, carries ~80 genes. While several genes have been investigated extensively, most lytic genes remain largely unexplored. Therefore, we cloned 71 EBV lytic genes into an expression vector and used reporter assays to screen for factors that activate signal transduction pathways, viral and cellular promoters. BGLF2 activated the AP-1 signaling pathway, likely by interacting with p38 and c-Jun N-terminal kinase (JNK), and increased infectivity of the virus. We also revealed that BKRF4 can negatively regulate AP-1 activity. Therefore, it is suggested that EBV exploits and modifies the AP-1 signaling pathway for its replication and survival. ABSTRACT Epstein-Barr virus (EBV) is a human gammaherpesvirus that causes infectious mononucleosis and several malignancies, such as endemic Burkitt lymphoma and nasopharyngeal carcinoma. Herpesviruses carry genes that can modify cell functions, including transcription and ubiquitination, thereby facilitating viral growth and survival in infected cells. Using a reporter screening system, we revealed the involvement of several EBV gene products in such processes. Of these, BGLF2 activated the AP-1 signaling pathway through phosphorylation of p38 and c-Jun N-terminal kinase (JNK). Knockout of the BGLF2 gene did not affect viral gene expression and viral genome DNA replication, but resulted in marked reduction of progeny titer. We also found that the BGLF2 disruption resulted in significant loss of infectivity upon de novo infection. Interestingly, expression of a binding partner, BKRF4, repressed the activation of AP-1 by BGLF2. These results shed light on the physiological role of the tegument protein BGLF2. IMPORTANCE Epstein-Barr virus (EBV), an oncogenic gammaherpesvirus, carries ~80 genes. While several genes have been investigated extensively, most lytic genes remain largely unexplored. Therefore, we cloned 71 EBV lytic genes into an expression vector and used reporter assays to screen for factors that activate signal transduction pathways, viral and cellular promoters. BGLF2 activated the AP-1 signaling pathway, likely by interacting with p38 and c-Jun N-terminal kinase (JNK), and increased infectivity of the virus. We also revealed that BKRF4 can negatively regulate AP-1 activity. Therefore, it is suggested that EBV exploits and modifies the AP-1 signaling pathway for its replication and survival.
Development of a prosthetic forearm aiming at humanlike motion for trans-radial amputation

The paper presents a design idea of prosthetic forearm for trans-radial amputees based on body power itself not on an external motorized power. This study aims at realizing humanlike pronation and supination for prosthetic forearms. The proposed has passive joints driven by residual motion of the amputated limb. For an experimental verification, we show that the trans-radial amputee with long remaining length is able to rotate his/her forearm as if he she rotated it before amputation.
Design and Control of a Novel Axial Flux Permanent Magnet In-Wheel Machine for HEVs

For hybrid electric vehicles with in-wheel drive, it is important for the motor to operate with constant power over a wide speed range and with the possibility of being operated with high flux weakening. It is however difficult for traditional surface mounted PM machines to produce constant-power for wide speed range, since the inductances of these machines are generally too small and hence cannot be adjusted readily to allow the motors to operate at constant power. In this paper, an axial flux Vernier PM direct-drive machine for in-wheel applications is proposed and analyzed. The stator windings have a fractional slot concentrated distribution with relatively high phase inductance. Its steady-state and transient performance is simulated using three-dimensional (3-D) finite-element methods (FEM) and the results are used to showcase the design validity of the proposed machine.
A Technology Integration Education (TIE) Model for Millennial Preservice Teachers: Exploring the Canonical Correlation Relationships Among Attitudes, Subjective Norms, Perceived Behavioral Controls, Motivation, and Technological, Pedagogical, and Content Knowledge (TPACK) Competencies

Abstract Intellectual goods can follow the same pattern as physical goods with the product life cycle of birth, growth, maturity, and decline. For the intellectual good of technological, pedagogical, and content knowledge (TPACK), its birth began with Shulman (1986, 1987). Canonical correlation analysis (CCA) was used to test the relationships among five of the 12 constructs in the technology integration education (TIE) model developed by Holland and Piper (2014). Based on the patterns of cross-loading correlations, this study found that there were limited correlational relationships between the set of independent variables and the set of dependent TPACK variables. For this pilot study, the sample consisted of 90 elementary education majors and 51 secondary education majors.
River Blindness: A Success Story under Threat?

“The accomplishments of this Programme inspire all of us in public health to dream big dreams. It shows we can reach ‘impossible’ goals and lighten the burden of millions of the world's poorest people …. ” These were the concluding words by former World Health Organization Director-General Gro Harlem Brundtland at the closure ceremony of the Onchocerciasis Control Programme in West Africa (OCP) in December 2002 [1]. The success of the OCP is so undeniable and exemplary, with 600,000 cases of blindness prevented, 18 million children born in areas freed from the risk of blindness, and 25 million hectares of land safe for resettlement, that river blindness is currently considered a disease of the past. This perception nonetheless forgets that OCP covered, at most, 1,200,000 square kilometers to protect 30 million people in 11 countries, leaving a remaining 100 million people in areas where active transmission of onchocerciasis still occurs. After its 28-year fight OCP may have won a battle, but a much more difficult task lies ahead before we can claim victory against river blindness [2].
The Modulatory Effects of Mesenchymal Stem Cells on Osteoclastogenesis

The effect of mesenchymal stem cells (MSCs) on bone formation has been extensively demonstrated through several in vitro and in vivo studies. However, few studies addressed the effect of MSCs on osteoclastogenesis and bone resorption. Under physiological conditions, MSCs support osteoclastogenesis through producing the main osteoclastogenic cytokines, RANKL and M-CSF. However, during inflammation, MSCs suppress osteoclast formation and activity, partly via secretion of the key anti-osteoclastogenic factor, osteoprotegerin (OPG). In vitro, co-culture of MSCs with osteoclasts in the presence of high concentrations of osteoclast-inducing factors might reflect the in vivo inflammatory pathology and prompt MSCs to exert an osteoclastogenic suppressive effect. MSCs thus seem to have a dual effect, by stimulating or inhibiting osteoclastogenesis, depending on the inflammatory milieu. This effect of MSCs on osteoclast formation seems to mirror the effect of MSCs on other immune cells, and may be exploited for the therapeutic potential of MSCs in bone loss associated inflammatory diseases.
MIPS code compression

MIPS machine code is very structured: registers used before are likely to be used again, some instructions and registers are used more heavily than others, some instructions often follow each other and so on. Standard file compression utilities, such as gzip and bzip2, does not take full advantage of the structure because they work on byte-boundaries and don't see the underlying instruction fields. My idea is to filter opcodes, registers and immediates from MIPS binary code into distinct streams and compress them individually to achieve better compression ratios. Several different ways to split MIPS code into streams are considered. The results presented in this paper shows that a simple filter can reduce final compressed size by up to 10 % with gzip and bzip2.
High quality harmonic excitation linear predictive speech coding at 2 kb/s

The paper presents a high quality harmonic excitation linear predictive (HE-LPC) speech coder operating at 2 kb/s based on a harmonic excitation model with two bands. The system incorporates novel features such as: combined pitch detection; residual harmonic matching voicing determination; extraction and interpolation of residual harmonic magnitudes. Subjective listening tests indicate that this coder has the same quality as that of the Federal Standard MELP (mixed excitation linear prediction) coder at 2.4 kb/s, whether the training database is from Chinese or English.
Prothrombin complex concentrate to correct acquired abnormalities of the clotting screen in patients with liver impairment

We respond to Desborough et al.1,2 and the accompanying edito‐ rial. It is clear, even from the audit parameters set by the authors, that the current understanding of coagulation abnormalities in cir‐ rhosis has not found widespread translation into clinical practice. The standards set for fresh frozen plasma (FFP) transfusion fol‐ low guidelines developed by the Cardiovascular and Interventional Radiological Society of Europe but, for reasons discussed in the editorial, it is not clear if these parameters are relevant in cirrhotic patients. Abnormal coagulation results do not necessarily predict bleeding, particularly in the context of cirrhosis, where there is a complex interplay of prohaemostatic and anticoagulant mecha‐ nisms. Inappropriate use of FFP in these patients may therefore even exceed that demonstrated by Desborough et al. However, there is little clinical data to clarify which patients with cirrhosis actually require correction and, in response to guidelines, physicians are often obliged to prescribe FFP (despite studies suggesting little effect3,4). Prothrombin complex concentrate (PCC) is an alternative, but use is not wellevidenced. We collected data for all patients at our institution issued PCC to correct acquired coagulopathies over a 26month period. Patient notes and electronic records were reviewed from the day of PCC ad‐ ministration until 14 days of followup. We noted demographics; co‐ agulopathy aetiology; PCC dose; preand postPCC prothrombin time (PT) and activated partial thromboplastin time (APTT). Fortyone patients were administered PCC; average dose 2463 IU. 44.0% had evidence of significant liver impairment. 73% were transfused because of bleeding; 15% prior to an interven‐ tional procedure and 5% empirically because of liver impairment.
Individual Differences and Social Influences on the Neurobehavioral Pharmacology of Abused Drugs

The interaction of drugs with biologic targets is a critical area of research, particularly for the development of medications to treat substance use disorders. In addition to understanding these drug-target interactions, however, there is a need to understand more fully the psychosocial influences that moderate these interactions. The first section of this review introduces some examples from human behavioral pharmacology that illustrate the clinical importance of this research. The second section covers preclinical evidence to characterize some of the key individual differences that alter drug sensitivity and abuse vulnerability, related primarily to differences in response to novelty and impulsivity. Evidence is presented to indicate that critical neuropharmacological mechanisms associated with these individual differences involve integrated neurocircuits underlying stress, reward, and behavioral inhibitory processes. The third section covers social influences on drug abuse vulnerability, including effects experienced during infancy, adolescence, and young adulthood, such as maternal separation, housing conditions, and social interactions (defeat, play, and social rank). Some of the same neurocircuits involved in individual differences also are altered by social influences, although the precise neurochemical and cellular mechanisms involved remain to be elucidated fully. Finally, some speculation is offered about the implications of this research for the prevention and treatment of substance abuse.
Graph Exploration by Multiple Linked Metric Views

The visualization of relational data by node-link diagrams quickly leads to a degradation of performance at some exploration tasks when the diagrams show visual clutter and overdraw. To address this challenge of large-data graph visualization, we introduce Graph Metric Views, a technique that enriches the visualization of traditional layout strategies for node-link diagrams by additionally allowing an analyst to interactively explore graph-specific metrics such as number of nodes, number of link crossings, link coverage, or degree of orthogonality. To this end, we support an analyst with additional histogram-like representations at the axes of the display space for graph-specific metrics. In this way, a cluttered and densely packed node-link diagram becomes more explorable even for dense graph regions: The user can use the distribution of metric values as an overview and then select regions of interest for further investigation and filtering.
Green mobile access network with dynamic base station energy saving (インターネットアーキテクチャ)

The explosive development of ICT (information and communication technology) industry has emerged as one of the major sources of world energy consumption. Therefore, this paper concerns about the BS (base station) energy saving issue, for most energy consumption of the communication network comes from the BSs and the core network. Particularly, we consider dynamically turning off certain BSs when the network traffic is low. Centralized and decentralized implementations are investigated. Simulations demonstrate the energy efficiency of the proposed algorithms and the tradeoff between energy saving and coverage guarantee.
Distractor Ratio Influences Patterns of Eye Movements during Visual Search

We examined the flexibility of guidance in a conjunctive search task by manipulating the ratios between different types of distractors. Participants were asked to decide whether a target was present or absent among distractors sharing either colour or shape. Results indicated a strong effect of distractor ratio on search performance. Shorter latency to move, faster manual response, and fewer fixations per trial were observed at extreme distractor ratios. The distribution of saccadic endpoints also varied flexibly as a function of distractor ratio. When there were very few same-colour distractors, the saccadic selectivity was biased towards the colour dimension. In contrast, when most of the distractors shared colour with the target, the saccadic selectivity was biased towards the shape dimension. Results are discussed within the framework of the guided search model.
An optimal evaluation of Boolean expressions in an online query system

A method is given for a fast evaluation of a Boolean expression of attributes against a record of a file, and it thus enables a faster response to general queries for reports from a data bank stored as a file. In this method, the time it takes to test a particular attribute in a record and the probability that the attribute is possessed by a record are taken into account to produce an evaluation algorithm for which the expected time of evaluation of the Boolean expression for a record is minimal.
SmartTravel: An approach to redolant Transportation Guiding Application in context of Bangladesh using OpenStreetMap

Travelling is a common phenomenon in our day to day life. For the requisite of different efficacy we have to travel all around. Choice of transportation depends on the time required to travel and our financial status. But it becomes a perplexing and tedious job if someone does not have knowledge about a route to travel. Since, different transport has a divergent level of service and rent. In this Paper, we have approached to an android based Transport Guiding Application (TGA) named `SmartTravel' which exploits OpenStreetMap (OSM) and is implemented for a specific region of Bangladesh. If a user is unknown about a city or place to travel, he/she at once can check out the necessary information through this application. It can help the user to choose a perfect service without facing any trouble. A survey is included to view the necessity of the implementation.
Latent class analysis of early developmental trajectory in baby siblings of children with autism.

BACKGROUND Siblings of children with autism (sibs-A) are at increased genetic risk for autism spectrum disorders (ASD) and milder impairments. To elucidate diversity and contour of early developmental trajectories exhibited by sibs-A, regardless of diagnostic classification, latent class modeling was used. METHODS Sibs-A (N = 204) were assessed with the Mullen Scales of Early Learning from age 6 to 36 months. Mullen T scores served as dependent variables. Outcome classifications at age 36 months included: ASD (N = 52); non-ASD social/communication delay (broader autism phenotype; BAP; N = 31); and unaffected (N = 121). Child-specific patterns of performance were studied using latent class growth analysis. Latent class membership was then related to diagnostic outcome through estimation of within-class proportions of children assigned to each diagnostic classification. RESULTS A 4-class model was favored. Class 1 represented accelerated development and consisted of 25.7% of the sample, primarily unaffected children. Class 2 (40.0% of the sample), was characterized by normative development with above-average nonverbal cognitive outcome. Class 3 (22.3% of the sample) was characterized by receptive language, and gross and fine motor delay. Class 4 (12.0% of the sample), was characterized by widespread delayed skill acquisition, reflected by declining trajectories. Children with an outcome diagnosis of ASD were spread across Classes 2, 3, and 4. CONCLUSIONS Results support a category of ASD that involves slowing in early non-social development. Receptive language and motor development is vulnerable to early delay in sibs-A with and without ASD outcomes. Non-ASD sibs-A are largely distributed across classes depicting average or accelerated development. Developmental trajectories of motor, language, and cognition appear independent of communication and social delays in non-ASD sibs-A.