Miracle-dz/UniFAR-FTUs huggingface dataset:
Cognitive training on stroke patients via virtual reality-based serious games

Abstract Purpose: Use of virtual reality environments in cognitive rehabilitation offers cost benefits and other advantages. In order to test the effectiveness of a virtual reality application for neuropsychological rehabilitation, a cognitive training program using virtual reality was applied to stroke patients. Methods: A virtual reality-based serious games application for cognitive training was developed, with attention and memory tasks consisting of daily life activities. Twenty stroke patients were randomly assigned to two conditions: exposure to the intervention, and waiting list control. Results: The results showed significant improvements in attention and memory functions in the intervention group, but not in the controls. Conclusions: Overall findings provide further support for the use of VR cognitive training applications in neuropsychological rehabilitation. Implications for Rehabilitation Improvements in memory and attention functions following a virtual reality-based serious games intervention. Training of daily-life activities using a virtual reality application. Accessibility to training contents.
Health Promotion at Local Level in Norway: The Use of Public Health Coordinators and Health Overviews to Promote Fair Distribution Among Social Groups

Background: Norway is internationally known today for its political and socio-economic prioritization of equity. The 2012 Public Health Act (PHA) aimed to further equity in the domain of health by addressing the social gradient in health. The PHA’s main policy measures were (1) delegation to the municipal level of responsibility for identifying and targeting underserved groups and (2) the imposition on municipalities of a "Health in All Policies" (HiAP) approach where local policy-making generally is considered in light of public health impact. In addition, the act recommended municipalities employ a public health coordinator (PHC) and required a development of an overview of their citizens’ health to reveal underserved social segments. This study investigates the relationship between changes in municipal use of HiAP tools (PHC and health overviews) with regard to the PHA implementation and municipal prioritization of fair distribution of social and economic resources among social groups. Methods: Data from two surveys, conducted in 2011 and 2014, were merged with official register data. All Norwegian municipalities were included (N=428). Descriptive statistics as well as bi- and multivariate logistic regression analyses were performed. Results: Thirty-eight percent of the municipalities reported they generally considered fair distribution among social groups in local policy-making, while 70% considered fair distribution in their local health promotion initiatives. Developing health overviews after the PHA’s implementation was positively associated with prioritizing fair distribution in political decision-making (odds ratio [OR] = 2.54; CI: 1.12-5.76), compared to municipalities that had not developed such overviews. However, the employment of PHCs after the implementation was negatively associated with prioritizing fair distribution in local health promotion initiatives (OR = 0.22; CI: 0.05-0.90), compared to municipalities without that position. Conclusion: Development of health overviews — as requested by the PHA — may contribute to prioritization of fair distribution among social groups with regard to the social determinants of health at the local level.
Fiber-optical Icing Sensor for Detecting the Icing Type

The existing icing sensors were unable to detect the icing type or only able to detect the icing type unreliably.Aimed at this problem,a fiber-optical icing sensor which could reliably detect the icing type was presented.Based on introducing the optical principle of detecting icing on the sensor and analyzing the light path,the sensor was designed.Then a lot of experiments to simulate the sensor's detecting icing were done in the lab environment,and it turned out that the results were effective and reliable.Finally the results show that the sensor can be used to detect the icing type(including the clear ice and rime ice)reliably and measure the icing thickness,and it has a promising application prospect.
The Atomistic Structure of Metal/Ceramic Interfaces Is the Key Issue for Developing Better Properties

Metal-metal-, ceramic-metal-composites (MMC, CMC) and related functional materials are steadily gaining interest for practical applications. This invited overview paper is divided into three parts. First, the importance of interfaces in material science is emphasized, then basics of computer modeling of interfaces on atomic scale is outlined, followed by the description of some interface examples and their applications. Atomistic modeling requires the specific determination of the orientation relationship between both crystal lattices facing the heterogeneous interface, the interface plane, and translation vectors of two facing crystals. Examples of the atomistic structure are described in this paper for interfaces, such as MgO/Ag, MgO/TiN, Al2O3/Fe, and others. The trend in this research is gradually, but steadily shifting from structural towards functional materials, because atomic binding at interfaces offers a broad spectrum of new properties to be utilized for applications.
Modelling of flow behaviour and dynamic recrystallization during hot deformation of MS-W 1200 using the phase field framework

A new simulation environment is developed to simulate the evolution of microstructure and the corresponding flow stress during rolling. An orientation dependent crystal plasticity hardening model is coupled to grain evolution-, recovery- and recrystallization kinetics within a phase field framework. Hardening and softening kinetics are treated consecutive to differentiate between individual effects. Simulation results are compared to hot compression tests at 1373 K with a strain rate of 1 s −1 .
Krüppel homolog 1 represses insect ecdysone biosynthesis by directly inhibiting the transcription of steroidogenic enzymes

Significance Two major endocrine hormones in insects, juvenile hormone (JH) and ecdysone, regulate developmental transitions and growth duration in an opposite manner. Deciphering the mechanisms underlying cross-talk between JH and ecdysone is key to understanding the control of insect growth and development. We show that in both Drosophila and Bombyx, JH directly acts on the prothoracic gland to induce Krüppel homolog 1 (Kr-h1) expression, which in turn represses ecdysone biosynthesis by reducing the transcription of steroidogenic enzymes. This transcriptional repression is mediated by direct binding of Kr-h1 to target gene-promoter regions, inducing epigenetic promoter DNA methylation. Our findings provide insights into the direct repression of ecdysone biosynthesis by Kr-h1–mediated JH signaling in insect prothoracic gland. In insects, juvenile hormone (JH) and the steroid hormone ecdysone have opposing effects on regulation of the larval–pupal transition. Although increasing evidence suggests that JH represses ecdysone biosynthesis during larval development, the mechanism underlying this repression is not well understood. Here, we demonstrate that the expression of the Krüppel homolog 1 (Kr-h1), a gene encoding a transcription factor that mediates JH signaling, in ecdysone-producing organ prothoracic gland (PG) represses ecdysone biosynthesis by directly inhibiting the transcription of steroidogenic enzymes in both Drosophila and Bombyx. Application of a JH mimic on ex vivo cultured PGs from Drosophila and Bombyx larvae induces Kr-h1 expression and inhibits the transcription of steroidogenic enzymes. In addition, PG-specific knockdown of Drosophila Kr-h1 promotes—while overexpression hampers—ecdysone production and pupariation. We further find that Kr-h1 inhibits the transcription of steroidogenic enzymes by directly binding to their promoters to induce promoter DNA methylation. Finally, we show that Kr-h1 does not affect DNA replication in Drosophila PG cells and that the reduction of PG size mediated by Kr-h1 overexpression can be rescued by feeding ecdysone. Taken together, our data indicate direct and conserved Kr-h1 repression of insect ecdysone biosynthesis in response to JH stimulation, providing insights into mechanisms underlying the antagonistic roles of JH and ecdysone.
Structural , optical , and electronic characterization of per fl uorinated sexithiophene fi lms and mixed fi lms with sexithiophene

We report on the growth and characterization of molecular mixed thin films of a-sexithiophene (6T), a well-known organic p-type semiconductor with high hole mobility, together with its perfluorinated counterpart, the so far rarely studied tetradecafluoro-a-sexithiophene (PF6T). Pure and blended thin films of these two molecules with different mixing ratios were grown on silicon oxide in ultrahigh vacuum by coevaporation. The effect of perfluorination and mixing on crystal structure, morphology, electronic, and optical properties was examined. The evolution of the PF6T crystal structure was followed in situ in real time by X-ray scattering. We found a new thin film structure different from the reported bulk phase with molecules either standing-up or lying-down depending on the growth temperature. The different morphologies of pure films and blends were investigated with atomic force microscopy. The impact of mixing on the core-levels and on the highest occupied molecular orbitals of 6T and PF6T is discussed.
The role of posttraumatic stress symptoms on chronic pain outcomes in chronic pain patients referred to rehabilitation

Objectives Posttraumatic stress symptoms (PTSS) are highly prevalent in chronic pain patients and may affect pain symptomatology negatively, but there is still a great need to explore exactly how this occurs. Therefore, this study investigated differences in pain intensity, pain-related disability, and psychological distress between chronic pain patients not exposed to a trauma, patients exposed to a trauma with no PTSS, and patients exposed to a trauma with PTSS. Moreover, the moderating effects of PTSS on the associations between pain intensity and pain-related disability and psychological distress were investigated. Methods In this cross-sectional cohort study, data were consecutively collected over the course of a year in patients with chronic non-malignant pain referred for multidisciplinary pain rehabilitation at a Danish university hospital pain center using questionnaires assessing pain, pain-related disability, PTSS, anxiety, and depression. Results The final sample consisted of 682 chronic pain patients, who were divided into three subgroups (no trauma, 40.6%; trauma/no PTSS, 40.5%; trauma/PTSS, 18.9%). Chronic pain patients with PTSS reported significantly higher levels of pain intensity, pain-related disability, depression, and anxiety compared to chronic pain patients without a trauma and chronic pain patients without PTSS. Moreover, PTSS significantly moderated the associations between pain intensity and pain-related psychosocial disability, depression, and anxiety. Conclusion These results highlight the importance of assessing PTSS in chronic pain patients and suggest that PTSS have a specific influence on the association between pain intensity and more psychosocial aspects of the pain condition.
Speckles of cryptic black‐headed gull eggs show no mechanical or conductance structural function

The structural-function hypothesis provides an alternative to signalling-based predictions to explain the remarkable diversity observed in avian eggshell colour. According to the hypothesis, protoporphyrin, the common pigment of visible speckles, lubricates and thus strengthens the shell and simultaneously moderates gas transfer across it. Correlational evidence for the structural-function hypothesis in form of a coincidence of both shell thinning and reduced evaporation with eggshell speckles comes from a restricted set of species with limited calcium supply or little nest predation and no need for camouflage of the eggs. Here, we investigate whether protoporphyrin-based pigmentation similarly affects a species with cryptically marked eggs and ample dietary calcium, the black-headed gull, Larus ridibundus. Although shell thinning of speckles occurred, this effect was minimal compared with thinning through embryonic growth. Furthermore, speckled and plain areas of the shell did not differ in water vapour conductance through the shell. We conclude that protoporphyrin speckling does not fulfil a structural function in gull eggs. Instead, during shell formation where the protoporphyrin of speckles is deposited in place of calcite it could inflict a structural cost. We propose that the mechanical and water vapour conductance functions of shell speckling need to be evaluated as separate hypotheses and that both functions could, in fact, negatively affect each other.
Short-term vision gains at 12 weeks correlate with long-term vision gains at 2 years: results from the BEVORDEX randomised clinical trial of bevacizumab versus dexamethasone implants for diabetic macular oedema

Aim To determine whether early vision gains predict long-term visual outcomes in the BEVORDEX randomised clinical trial of bevacizumab or dexamethasone implants for diabetic macular oedema. Methods Post hoc analysis of 68 study eyes (77%) that completed 2 years follow-up of the BEVORDEX multicentre randomised clinical trial set in Australia (ClinicalTrials.gov identifier: NCT01298076). Study eyes from both groups were combined and stratified by visual acuity (VA) change in the first 12 weeks in to three groups: (a) suboptimal gain: <5 letters gain (includes VA loss), (b) moderate gain: 5–9 letters gain, (c) pronounced gain: ≥10 letters gain. This was correlated with VA outcome at 104 weeks taking into account treatment allocation and baseline lens status. Results The change in VA in the first 12 weeks was significantly correlated with VA change at 104 weeks (p<0.001). This was independent of treatment allocation (p=0.353) and lens status at baseline (p=0.593). The change in central macular thickness at 12 weeks did not correlate with VA gain at 104 weeks (p=0.847). Conclusion Short-term visual gain at 12 weeks was strongly correlated with long-term vision improvement independent of treatment allocation or baseline lens status. Early improvement in central macular thickness was not predictive of long-term visual outcomes. Trial registration number NCT01298076, Post-results.
Utility-Aware Ridesharing on Road Networks

Ridesharing enables drivers to share any empty seats in their vehicles with riders to improve the efficiency of transportation for the benefit of both drivers and riders. Different from existing studies in ridesharing that focus on minimizing the travel costs of vehicles, we consider that the satisfaction of riders (the utility values) is more important nowadays. Thus, we formulate the problem of utility-aware ridesharing on road networks (URR) with the goal of providing the optimal rider schedules for vehicles to maximize the overall utility, subject to spatial-temporal and capacity constraints. To assign a new rider to a given vehicle, we propose an efficient algorithm with a minimum increase in travel cost without reordering the existing schedule of the vehicle. We prove that the URR problem is NP-hard by reducing it from the 0-1 Knapsack problem and it is unlikely to be approximated within any constant factor in polynomial time through a reduction from the DENS k-SUBGRAPH problem. Therefore, we propose three efficient approximate algorithms, including a bilateral arrangement algorithm, an efficient greedy algorithm and a grouping-based scheduling algorithm, to assign riders to suitable vehicles with a high overall utility. Through extensive experiments, we demonstrate the efficiency and effectiveness of our URR approaches on both real and synthetic data sets.
NanoEHS – defining fundamental science needs: no easy feat when the simple itself is complex

Nanotechnology is no longer in its infancy and has made significant advances since the implementation of the National Nanotechnology Initiative (NNI) in 2000. Incorporation of nanotechnology in many fields including information technology, medicine, materials, energy, catalysis and cosmetics has led to an increase in engineered nanomaterial (ENM) production, and consequently, increased nanomaterial use. In comparison, the generation of concrete and consistent evidence related to the environmental health and safety of nanomaterials (NanoEHS) is lacking. The main factors contributing to the slower progress in NanoEHS versus conventional EHS are related to the complexity, property transformations, life cycles and behavior of nanomaterials even in carefully controlled environments. Therefore, new systematic, integrated research approaches in NanoEHS are needed for overcoming this complexity and bridging current knowledge gaps. A workshop on “NanoEHS: Fundamental Science Needs” brought together scientists and engineers to identify current fundamental science challenges and opportunities within NanoEHS. Detailed discussions were conducted on identifying the fundamental properties that are critical in NanoEHS, differentiating between conventional and NanoEHS studies as well as understanding, the effect of dynamic transformations on nanometrology, role of dosimetry and mechanistic data gaps in nanotoxicology. An important realization that even simple nanoscale materials can be complex when considering NanoEHS implications was noted several times during the workshop. Despite this fact, a number of fundamental research areas to further the scientific foundation to address NanoEHS needs are suggested.
Melatonin: A Molecule for Reducing Breast Cancer Risk

The objective of this article is to review the basis supporting the usefulness of melatonin as an adjuvant therapy for breast cancer (BC) prevention in several groups of individuals at high risk for this disease. Melatonin, as a result of its antiestrogenic and antioxidant properties, as well as its ability to improve the efficacy and reduce the side effects of conventional antiestrogens, could safely be associated with the antiestrogenic drugs presently in use. In individuals at risk of BC due to night shift work, the light-induced inhibition of melatonin secretion, with the consequent loss of its antiestrogenic effects, would be countered by administering this neurohormone. BC risk from exposure to metalloestrogens, such as cadmium, could be treated with melatonin supplements to individuals at risk of BC due to exposure to this xenoestrogen. The BC risk related to obesity may be reduced by melatonin which decrease body fat mass, inhibits the enhanced aromatase expression in obese women, increases adiponectin secretion, counteracts the oncogenic effects of elevated concentrations of leptin; and decreases blood glucose levels and insulin resistance. Despite compelling experimental evidence of melatonin’s oncostatic actions being susceptible to lowering BC risk, there is still a paucity of clinical trials focused on this subject.
Acclimation of a terrestrial plant to submergence facilitates gas exchange under water

Flooding imposes stress upon terrestrial plants since it severely hampers gas exchange rates between the shoot and the environment. The resulting oxygen deficiency is considered to be the major problem for submerged plants. Oxygen microelectrode studies have, however, shown that aquatic plants maintain relatively high internal oxygen pressures under water, and even may release oxygen via the roots into the sediment, also in dark. Based on these results, we challenge the dogma that oxygen pressures in submerged terrestrial plants immediately drop to levels at which aerobic respiration is impaired. The present study demonstrates that the internal oxygen pressure in the petioles of Rumex palustris plants under water is indeed well above the critical oxygen pressure for aerobic respiration, provided that the air-saturated water is not completely stagnant. The beneficial effect of shoot acclimation of this terrestrial plant species to submergence for gas exchange capacity is also shown. Shoot acclimation to submergence involved a reduction of the diffusion resistance to gases, which was not only functional by increasing diffusion of oxygen into the plant, but also by increasing influx of CO 2 , which enhances underwater photosynthesis.
Oxytocin facilitates reciprocity in social communication

Abstract Synchrony in social groups may confer significant evolutionary advantages by improving group cohesion and social interaction. However, the neurobiological mechanisms translating social synchrony into refined social information transmission between interacting individuals are still elusive. In two successively conducted experiments involving a total of 306 healthy volunteers, we explored the involvement of the neuropeptide oxytocin (OXT) in reciprocal social interaction. First, we show that synchronous social interactions evoke heightened endogenous OXT release in dyadic partners. In a second step, we examined the consequences of elevated OXT concentrations on emotion transmission by intranasally administering synthetic OXT before recording emotional expressions. Intriguingly, our data demonstrate that the subjects’ facial and vocal expressiveness of fear and happiness is enhanced after OXT compared with placebo administration. Collectively, our findings point to a central role of social synchrony in facilitating reciprocal communication between individuals via heightened OXT signaling. Elevated OXT concentrations among synchronized individuals seem to augment the partners’ emotional expressiveness, thereby contributing to improved transmission of emotional information in social communication.
Discriminative Semantic Subspace Analysis for Relevance Feedback

Content-based image retrieval (CBIR) has attracted much attention during the past decades for its potential practical applications to image database management. A variety of relevance feedback (RF) schemes have been designed to bridge the gap between low-level visual features and high-level semantic concepts for an image retrieval task. In the process of RF, it would be impractical or too expensive to provide explicit class label information for each image. Instead, similar or dissimilar pairwise constraints between two images can be acquired more easily. However, most of the conventional RF approaches can only deal with training images with explicit class label information. In this paper, we propose a novel discriminative semantic subspace analysis (DSSA) method, which can directly learn a semantic subspace from similar and dissimilar pairwise constraints without using any explicit class label information. In particular, DSSA can effectively integrate the local geometry of labeled similar images, the discriminative information between labeled similar and dissimilar images, and the local geometry of labeled and unlabeled images together to learn a reliable subspace. Compared with the popular distance metric analysis approaches, our method can also learn a distance metric but perform more effectively when dealing with high-dimensional images. Extensive experiments on both the synthetic data sets and a real-world image database demonstrate the effectiveness of the proposed scheme in improving the performance of the CBIR.