Miracle-dz/UniFAR-FTUs huggingface dataset:
Current Findings on Australian Children in Postseparation Disputes: Outer Conflict, Inner Discord1

This paper sets out descriptive baseline data on the first 111 Australian families participating in a current study of the efficacy of child-focused and child-inclusive Family Law Mediation. The families come from the first of two treatment groups in that comparative study. While outcome data are not yet available on this group, the baseline data, gathered prior to intervention, are of interest and value. The paper describes the nature of parents’ conflict with each other, the strength of their parental alliance, and the psychological functioning of their children at the time of presentation to the mediation service. High mental health risk for the children in these families is evident, both from parents’ and children’s perspectives. Uniquely, the paper includes the perceptions of 73 children about their parents’ conflict and its impact on them. Implications are discussed, underscoring the imperative of early intervention with separating families that includes screening of the children’s experience of conflict and their own needs for recovery.
The distressed (Type D) personality is independently associated with tinnitus: a case-control study.

BACKGROUND Tinnitus is a common and disturbing condition, reported by 10% to 20% of the general population. OBJECTIVE The authors sought to determine personality characteristics associated with tinnitus patients versus a control group of ear-nose-throat (ENT) patients without tinnitus. METHOD Adult chronic tinnitus sufferers (N=265) and ENT patients without tinnitus (N=265) participated in a cross-sectional study. The authors evaluated personality characteristics with tests for distressed personality (Type D), neuroticism, extraversion, and emotional stability. RESULTS As compared with control subjects, tinnitus patients had statistically significant and clinically relevant higher levels of neuroticism, negative affectivity, and social inhibition, on one hand, and lower levels of extraversion and emotional stability on the other hand. Also, tinnitus patients were more likely to have a type D personality. CONCLUSIONS Neuroticism, reduced extraversion, and reduced emotional stability were associated with tinnitus, but the level of prediction of the model improved with the addition of type D personality to the single traits. This might indicate that personality characteristics, and type D personality, in particular, are associated with having tinnitus and might contribute to its perceived severity.
Induction of Mitochondrial Dysfunction and Oxidative Damage by Antibiotic Drug Doxycycline Enhances the Responsiveness of Glioblastoma to Chemotherapy

Background Inducing mitochondrial dysfunction has been recently demonstrated to be an alternative therapeutic strategy for cancer treatment. Doxycycline is an antibiotic that has been shown to have anti-cancer activities in various cancers by way of targeting mitochondria. In this work, we examined whether doxycycline can be repurposed for glioblastoma treatment. Material/Methods The effects of doxycycline on the growth, survival, and mitochondrial metabolisms of glioblastoma were investigated. The efficacy of a combination of doxycycline with temozolomide was examined using xenograft mouse model in total number of 40 mice. Results Doxycycline targeted glioblastoma cell lines, regardless of their origin, through inhibiting growth and inducing cell death, accompanied by a significant decrease in proliferating cell nuclear antigen (PCNA) and increase in cleaved caspase-3. In addition, doxycycline significantly sensitized glioblastoma cell response to temozolomide in vitro and in vivo. Mechanistically, doxycycline disrupted mitochondrial functions through decreasing mitochondrial membrane potential and mitochondrial respiration. Inducing mitochondrial dysfunctions by using doxycycline led to energy crisis, oxidative stress, and damage as shown by the decreased levels of ATP and the elevated levels of mitochondrial superoxide, intracellular ROS, 8-OHdG, protein carbonylation, and lipid peroxidation. An antioxidant N-acetyl-L-cysteine (NAC) significantly abolished the anti-proliferative and pro-apoptotic effects of doxycycline, demonstrating that doxycycline acts on glioblastoma via inducing oxidative stress. Conclusions In our study, we show that the antibiotic doxycycline is effective in targeting glioblastoma through inducing mitochondrial dysfunctions and oxidative stress. Our work also demonstrated the importance of mitochondrial metabolism in glioblastoma.
Education and Services for Children and Youths With Emotional and Behavioral Disorders in Singapore

To describe the current status of special education and services for children and youths with emotional and behavioral disorders (E/BD) in Singapore, the authors highlight the country's overall structure of special education and mental health, identification of and intervention with children and youths with E/BD, perspectives about E/BD, and unique features of the service delivery system. The authors also discuss challenges to enhance the quality of educational services and future possibilities in Singapore.
Ad Hoc Wireless Networks : a Communication-Theoretic Approach

Ad hoc wireless networking is currently a hot research area, especially because there is an increasing need for connectivity “anywhere” and, in particular, “anyhow. ” While traditional networks have fixed nodes with wired connections (either optical fibers or copper lines), ad hoc wireless networks can be described as multi-hop wireless networks with mobile nodes. However, the mobility condition can be relaxed, and we can consider an ad hoc wireless network as a network where all the nodes are connected to the local environment through wireless links, and where there is not a central or dominant node--as opposed to, for example, the case of cellular wireless networks where a base station is located in each cell. All the nodes in an ad hoc wireless network are at the same hierarchical level. In this sense, sensor networks can be regarded as a special case of ad hoc wireless networks.
Book Review Essay

This book, one in the Tavistock Clinic series, sets out ‘to understand the states of mind that underlie. anorexia and bulimia’ and ‘to help practitioners find meaning in the illnesses of their patients’ (p. 1). There is a need for such a project, since despite the many advances in patient care over the past 15 years or so, the patients themselves are dissatisfied with the treatment they receive (Newton, Robinson, & Hartley, 1993; Rother & Buckroyd, 2004). Treatment outcomes for anorexia are still in general poor (NICE, 2004). The central question of how to understand anorexia has not yet received a convincing answer. There are numerous helpful thoughts and perceptions in this book that can certainly improve the general level of understanding of anorexia in those engaged in treatment in whatever setting. The fundamental idea that eating disorders have meaning is already well understood in psychodynamic circles, but still comes as news to many parents and to many of those working with patients. Equally, Lawrence alerts the reader to the associated difficulty for many of those concerned with a patient, to continue to think about what is going on with her, rather than simply reacting to what is often alarming behaviour. A huge body of work has linked psychological disorders of all kinds to earlier failures in relationship; Lawrence is aligning herself with attachment researchers from many different traditions when she asserts that ‘underlying all eating disorders are relationship disorders’ (p. 20). She describes the need for the development of an autonomous and separate self by patients who are often still enmeshed with their mothers. She comments that the obsessional and preoccupying nature of eating disorders is a powerful distraction from this task. She emphasises that what the anorexic insists is behaviour to control the body is, in fact intended to control her mind, her inner world. She makes valuable acknowledgement that the work with anorexics is best undertaken as part of a multi-disciplinary team, especially when the physical condition of the patient gives cause for concern. Furthermore, Lawrence gives due recognition to the contribution that can be made to treatment by family therapy and cognitive therapies. Her contention that Psychodynamic Practice Vol. 16, No. 2, May 2010, 227–232
Developmental Differences in Children's Perception of Maternal Socialization Behavior.

APPEL, YETTA H. Developmental Differences in Children's Perception of Maternal Socialization Behavior. CHILD DEVELOPMENT, 1977, 48, 1689-1693. This study explored developmental differences in children's perception of maternal socialization behavior based on Piaget's developmental psychology. It was hypothesized that children at the preoperational stage of development would prefer an essentially permissive mother rather than one who attempts to socialize, when compared with concrete operational children. 60 kindergarten children and 70 third graders, matched on ethnicity, socioeconomic status, and intactness of mother-child relationship, equally divided as to sex, were interviewed with a story inventory. Statistically significant developmental differences were found (but no sex differences) in that the younger children evaluated the permissive mother positively, while the older children were consistently negative.
Risk indicators for oral candidiasis and oral hairy leukoplakia in HIV-infected adults.

OBJECTIVES Oral candidiasis (OC) and oral hairy leukoplakia (OHL) are the most common oral mucosal diseases associated with HIV infection. Independent risk indicators associated with these sentinel opportunistic diseases have not been established in mixed race and gender adult populations in the southeast USA. The purposes of this study were 1) to estimate prevalence of OC and OHL among an HIV-1 positive adult population, and 2) to develop explanatory multivariable models for each disease outcome. METHODS This cross-sectional study evaluated 631 adult dentate HIV-1 seropositive persons examined for HIV-associated oral mucosal diseases between 1995 and 2000 at University of North Carolina Hospitals in Chapel Hill, North Carolina using data collected from medical record review, interview questionnaire and clinical examination. We analyzed the data using t-tests, anova, and unconditional logistic regression. RESULTS Prevalent OC was associated with low CD4+ cell count [<200 cells/microl, adj. OR = 12.7 (95%CI: 4.9-32.9)], antiretroviral combination therapy [OR = 0.6 (0.3-0.9)], and current smoking [OR = 2.5 (1.3-4.8)]. Prevalent OHL was associated with low CD4+ cell count [<200 cells/microl, OR = 7.2 (2.7-18.9)], antifungal medication use [OR = 1.8 (1.1-2.9)], current recreational drug use [OR = 2.5 (1.3-4.9)], and male gender [OR = 2.5 (1.3-4.8)]. CONCLUSIONS While CD4+ cell count, and antiretroviral medication were important risk indicators for OC, and OHL, cigarette smoking appears to be an important risk indicator for OC in HIV-1-infected populations.
Ethics and the Chimera of Professionalism: The Historical Context of an Oxymoronic Relationship

Like the Chimera of Greek mythology—an imaginary monster compounded of incongruous parts—professionalism has assimilated ethics as a part of its ordinary definition. In this paper, the relationship between professionalism and ethics is examined in historical context, which suggests the association of the two occurred during and just after the Progressive Era. It was during this period of time that technical rationality overwhelmed earlier understandings of professionalism—ones more conducive to moral reasoning. This paper addresses the prospects for a new professionalism in our present modern historical circumstances.
High-Speed Silicon Modulator With Slow-Wave Electrodes and Fully Independent Differential Drive

We demonstrate a fully independent differential-drive capable of traveling-wave modulator in silicon using slow-wave transmission line electrode. The reported 3.5-mm device achieves a bandwidth of 27 GHz at -1 V bias with 7.8-V small signal Vπ and 50-Ω impedance. Raising the impedance to this extent requires effectively expanding the RF mode size and radically changes the RF phase velocity, but we show that this can be done with minimal crosstalk effects between the two arms and overall velocity mismatch, and thus, with a high EO bandwidth achieved. 40-Gb/s operation is demonstrated with 1.6-Vpp differential-drive, and performance comparisons to Lithium Niobate modulators are made.
Poly(ethylene glycol) Hydrogel Microspheres as a Controlled Release Device

Vaccines for infections such as measles, polio, or chicken pox contain live attenuated viruses, which can sometimes lead to infection. Our objective is to develop an improved strategy for vaccines that induces patent immune responses against persistent viral infections. Three processes must occur to successfully produce immunity; the first is the attraction of immature Dendritic Cells (DCs), loading them with particular antigens, and then maturing the DCs. This project focuses on DC attraction to an immunization site by fabricating crosslinked polyethylene glycol hydrogel microspheres that encapsulate a chemoattractant. This study was performed to determine whether the diffusion of the chemoattractant could be controlled by varying the amount of crosslinker and by incorporating ionic groups in the polymer matrix. It was found that the crosslinker amounts successfully altered the release profiles of the protein. The ionic groups incorporated in the polymer matrix effectively altered the diffusion of both positively and negatively charged protein diffusion. Thesis Supervisor: Darrell J. Irvine Title: Assistant Professor of Materials Science and Engineering and Biological Engineering
Performance Analysis of Digital Image Steganographic Algorithm

Steganography is the technique with which the confidential data is hidden under the cover medium such as image, without reflecting any clue on the cover image. Many algorithms are designed to provide the security for the communication of data over the Internet. The good steganographic algorithm is identified by the performance of the algorithm measured with the help of the parameters such as PSNR, MSE, robustness and capacity to hide the information in the cover image. This paper analyzed the Digital Image Steganographic algorithms in spatial and frequency domain.
The Use of a Fuzzy Cognitive Maps and Eye Tracking in Exploitation of Online Advertising Resources

Current trends in the area of digital marketing and online promotion indicate the increasing role of highly targeted online advertising. The method of designing advertisements evolved in the direction of one-to-one communication, which forces to create personalized advertising messages. In the case of interactive media modelling changes can occur in a dynamic way based on audience and content characteristics. The purpose of this article is to develop a model supporting the selection of parameters and localization of advertising content with the use of fuzzy cognitive maps and possibility to perform simulations based on content selection towards increased efficiency.
2-Chloro-6-fluorobenzoic acid

The title compound, C7H4ClFO2, is a twofold halogenated derivative of benzoic acid. The C—C—C angles within the aromatic moiety cover a range 116.11 (14)–123.96 (15)°, with the maximum and the minimum value next to each other. In the crystal, O—H⋯O hydrogen bonds form carboxylic acid dimers, which are further connected by C—H⋯F contacts into undulating sheets perpendicular to the a axis.
The Effect of Polyphenols in Olive Oil on Heart Disease Risk Factors

TO THE EDITOR: Covas and colleagues (1) found that consumption of polyphenol-rich olive oil increased high-density lipoprotein (HDL) cholesterol levels and lowered levels of oxidative stress markers and oxidized low-density lipoprotein (LDL) cholesterol. We suggest that some of the involved mechanisms might be related to interactions of endogenous iron with polyphenols absorbed from the olive oil. The polyphenols may augment the antioxidant activity of endogenous iron-binding antioxidants (2). Use of phlebotomy to achieve modest decreases in stored iron level (3) or induction of near iron deficiency (4) is associated with increased HDL cholesterol concentration. Polyphenol-rich olive oil may acutely augment the reactive iron-neutralizing activity of endogenous iron-binding antioxidants. In prolonged use, olive oilderived polyphenols are associated with progressive loss of iron stores (5). Lowering the availability of reactive iron in vivo either by decreasing stored iron level or by acute iron chelation may improve antioxidant activity and increase HDL cholesterol levels by closely related mechanisms (6).
Population Diversification in a Yeast Metabolic Program Promotes Anticipation of Environmental Shifts

Delineating the strategies by which cells contend with combinatorial changing environments is crucial for understanding cellular regulatory organization. When presented with two carbon sources, microorganisms first consume the carbon substrate that supports the highest growth rate (e.g. glucose) and then switch to the secondary carbon source (e.g. galactose), a paradigm known as the Monod model. Sequential sugar utilization has been attributed to transcriptional repression of the secondary metabolic pathway, followed by activation of this pathway upon depletion of the preferred carbon source. In this work, we challenge this notion. Although Saccharomyces cerevisiae cells consume glucose before galactose, we demonstrate that the galactose regulatory pathway is activated in a fraction of the cell population hours before glucose is fully consumed. This early activation reduces the time required for the population to transition between the two metabolic programs and provides a fitness advantage that might be crucial in competitive environments. Importantly, these findings define a new paradigm for the response of microbial populations to combinatorial carbon sources.
Adrenal toxicity in dogs and cats as a contributing cause of hormonal and immune destabilization

The adrenal cortex is regarded as the organ most vulnerable to toxicity within the endocrine system. The production of cortisol, among the many steroidal hormones produced by the cortex, may suffer as a result. In a veterinary clinical practice, household dogs and cats with a wide variety of diseases ranging from allergies to cancer commonly have a cortisol deﬁciency or defect that triggers endocrine imbalances and immune system destabilization. The causes of deﬁcient cortisol are linked primarily to genetics but also to acquired adrenal damage likely stemming from environmental toxins. An innovative blood test to determine relevant endocrine–immune imbalances in pets and a treatment method based on low‐dosage steroidal medication, as a form of cortisol replacement therapy, are described. Despite a prevailing reluctance to use steroidal medications long term because of the fear of side effects, extended and even life‐time usage of these medications at low, physiologic dosages has been applied successfully for decades and appears to be gaining wider acceptance. The validity of a combined testing and treatment method for humans based on the veterinary model deserves investigation as a tool with which to identify and correct toxic damage to adrenal function. Copyright © 2004 John Wiley & Sons, Ltd.
Gasserian ganglion neurosarcoidosis mimicking trigeminal schwannoma.

AMRIofa59-year-oldmalewithrighthemifacialhypoesthe-siashowedalowsignalT2-weightedexpansivemassintherightMeckel’s cave. After failure of initial conservative treatment(Figure 1), surgery was done with partial lesion resection(Figure 2). The pathology and chest CT were consistent withgranulomatous disease: neurosarcoidosis. On follow-up thelesion increased in size but after corticosteroids it reversed(Figure 3). The involvement of the trigeminal nerve is very rarewith only few cases described in literature. Although rare, sar-coid infiltration of the Gasserian ganglion must be consideredinthedifferentialdiagnosisofanisolatedmassatMeckel ’scave,especially if it has T2 hypointensity signal.
Instability of the Middle Cerebral Artery Blood Flow in Response to CO2

Background The middle cerebral artery supplies long end-artery branches to perfuse the deep white matter and shorter peripheral branches to perfuse cortical and subcortical tissues. A generalized vasodilatory stimulus such as carbon dioxide not only results in an increase in flow to these various tissue beds but also redistribution among them. We employed a fast step increase in carbon dioxide to detect the dynamics of the cerebral blood flow response. Methodology/Principal Findings The study was approved by the Research Ethics Board of the University Health Network at the University of Toronto. We used transcranial ultrasound to measure the time course of middle cerebral artery blood flow velocity in 28 healthy adults. Normoxic, isoxic step increases in arterial carbon dioxide tension of 10 mmHg from both hypocapnic and normocapnic baselines were produced using a new prospective targeting system that enabled a more rapid step change than has been previously achievable. In most of the 28 subjects the responses at both carbon dioxide ranges were characterised by more complex responses than a single exponential rise. Most responses were characterised by a fast initial response which then declined rapidly to a nadir, followed by a slower secondary response, with some showing oscillations before stabilising. Conclusions/Significance A rapid step increase in carbon dioxide tension is capable of inducing instability in the cerebral blood flow control system. These dynamic aspects of the cerebral blood flow responses to rapid changes in carbon dioxide must be taken into account when using transcranial blood flow velocity in a single artery segment to measure cerebrovascular reactivity.
Combining Domain-Specific Languages and Ontology Technologies ?

This paper presents an approach of using ontology technologies together with domain-specific languages (DSLs). After identification of some issues and challenges in the development and use of DSLs, we propose a solution that allows the specification of DSLs with seamless integrated ontologies. The specified DSL can be used to build several domain-specific models. Simultaneously reasoning services can be invoked to support the modeling by suggestions and debugging. Furthermore we comment on future work of this approach and on related work.
An evolutionary model of influenza A with drift and shift

Influenza A virus evolves through two types of evolutionary mechanisms – drift and shift. These two evolutionary mechanisms allow the pathogen to infect us repeatedly, as well as occasionally create pandemics with large morbidity and mortality. Here we introduce a novel model that incorporates both evolutionary mechanisms. This necessitates the modelling of three types of strains – seasonal human strains, bird-to-human transmittable H5N1 strains and evolved pandemic H5N1 strain. We define reproduction and invasion reproduction numbers and use them to establish the presence of dominant and coexistence equilibria. We find that the amino acid substitution structure of human influenza can destabilize the human influenza equilibrium and sustained oscillations are possible. We find that for low levels of infection in domestic birds, these oscillations persist, inducing oscillations in the number of humans infected with the avian flu strain. The oscillations have a period of 365 days, similar to the one that can be observed in the cumulative number of human H5N1 cases reported by the World Health Organization (WHO). Furthermore, we establish some partial global results on the competition of the strains.