Miracle-dz/UniFAR-FTUs huggingface dataset:
How best to assess right ventricular function by echocardiography*

Abstract Right ventricular function is a crucial determinant of long-term outcomes of children with heart disease. Quantification of right ventricular systolic and diastolic performance by echocardiography is of paramount importance, given the prevalence of children with heart disease, particularly those with involvement of the right heart, such as single or systemic right ventricles, tetralogy of Fallot, and pulmonary arterial hypertension. Identification of poor right ventricular performance can provide an opportunity to intervene. In this review, we will go through the different systolic and diastolic indices, as well as their application in practice. Quantification of right ventricular function is possible and should be routinely performed using a combination of different measures, taking into account each disease state. Quantification is extremely useful for individual patient follow-up. Laboratories should continue to strive to optimise reproducibility through quality improvement and quality assurance efforts in addition to investing in technology and training for new, promising techniques, such as three-dimensional echocardiography.
In Vitro Performance Testing of a Pediatric Oxygenator With an Integrated Pulsatile Pump

For different lung and heart diseases (e.g., acute respiratory distress syndrome, congenital heart failure, and cardiomyopathy) extracorporeal membrane oxygenation is a well-established therapy, particularly in the field of neonatal and pediatric medicine. To reduce the priming volume of the extracorporeal circuit, different components can be combined. In this study, an oval-shaped oxygenator (called ExMeTrA) with integrated pulsatile pump was tested in vitro using porcine blood. A feasibility study regarding the performance of collapsing and expanding silicone tubes within an oxygenator fiber bundle as a pulsatile pump was previously completed with successful results. The findings of this study improve upon the previous feasibility results, particularly in terms of gas exchange and filling volume. Five modules were manufactured in sizes of 20 ± 2.2 ml (priming volume) with fiber surface areas of 0.24 ± 0.027 m2 and an analytically calculated volume pumping capacity of 692 ± 75 ml/min. The modules were made of polymethylpentene fibers with dense outer layer to permit long-term applications. The gas exchange rates at a gas/blood flow ratio of 2:1 were between 64 and 72.7 mlo2/lblood and between 62.5 and 81.5 ml/lblood, depending on the blood flow. The individual module’s pumping capacity ranged from 200–500 ml/min thus providing room for further improvements. In order to enhance the pumping capacity while maintaining sufficient gas exchange rates future optimization, adjustments will be made to the inlet and outlet geometries.
A Case of Bilateral Corneal Epithelial Dysplasia Characterized by Laser Confocal Biomicroscopy and Cytokeratin Immunofluorescence

Purpose: To describe a case of bilateral corneal epithelial dysplasia in which each lesion was characterized by both laser confocal biomicroscopy and cytokeratin immunofluorescence. Methods: A 52-year-old Japanese woman with bilateral corneal epithelial dysplasia was treated by corneal epithelial debridement. We observed the affected area with laser confocal biomicroscopy before and after treatment and examined the immunofluorescence of cytokeratins to examine the characteristics of the abnormal epithelial cells. Results: Laser confocal biomicroscopy revealed the atypical epithelial cells in all layers of the corneal epithelium as well as the reconstituted normal structure of the corneal epithelium after epithelial debridement. Immunofluorescence of cytokeratin 12 (K12) and K4 revealed the presence of four types of cells (those positive for one, both or neither of these cytokeratins) in each lesion. Conclusion: Cells expressing both K12 and K4 probably represented dysplastic cells that had invaded the cornea via the limbus and adopted characteristics of corneal epithelial cells. Cells lacking both K12 and K4 were probably either undifferentiated cells or epithelial cells in which cytokeratin expression had not been initiated.
Gaddum Memorial Lecture 2014: receptors as an evolving concept: from switches to biased microprocessors

This review is based on the JR Vane Medal Lecture presented at the BPS Winter Meeting in December 2014 by T. Kenakin. A recording of the lecture is included as supporting information and can also be viewed online here: https://www.youtube. com/watch? v=xrP81AQ8l‐8. Pharmacological models used to describe drug agonism and antagonism have evolved over the past 20 years from a parsimonious model describing single active and inactive receptor states to models of multiconformational receptor systems modified by ligand conformational selection. These latter models describe the observed, presently underexploited, pharmacological mechanism of ligand‐directed biased signalling. Biased signals can be quantified with transduction coefficients (ΔΔLog(τ/KA) values), a scale grounded in the Black/Leff operational model; this enables the optimization of biased profiles through medicinal chemistry. The past decades have also brought the availability of new technologies to measure multiple functional effects mediated by seven transmembrane receptors. These have confirmed that drugs can have many efficacies, which may be collaterally linked, that is there is no linear sequence of activities required. In addition, new functional screening assays have introduced increasing numbers of allosteric ligands into drug discovery. These molecules are permissive (they do not necessarily preclude endogenous signalling in vivo); therefore, they may allow better fine tuning of pathological physiology. The permissive quality of allosteric ligands can also change the quality of endogenous signalling efficacy (‘induced bias’) as well as the quantity of signal; in this regard, indices related to ΔΔLog(τ/KA) values (namely ΔLog(αβ) values) can be used to quantify these effects for optimization in the drug discovery process. All of these added scales of drug activity will, hopefully, allow better targeting of candidate molecules towards therapies.
Glacier Surge Mechanism: 1982-1983 Surge of Variegated Glacier, Alaska

The hundredfold speedup in glacier motion in a surge of the kind the kind that took place in Variegated Glacier in 1982-1983 is caused by the buildup of high water pressure in the basal passageway system, which is made possible by a fundamental and pervasive change in the geometry and water-transport characteristics of this system. The behavior of the glacier in surge has many remarkable features, which can provide clues to a detailed theory of the surging process. The surge mechanism is akin to a proposed mechanism of overthrust faulting.
Genetic subdivision and candidate genes under selection in North American grey wolves

Previous genetic studies of the highly mobile grey wolf (Canis lupus) found population structure that coincides with habitat and phenotype differences. We hypothesized that these ecologically distinct populations (ecotypes) should exhibit signatures of selection in genes related to morphology, coat colour and metabolism. To test these predictions, we quantified population structure related to habitat using a genotyping array to assess variation in 42 036 single‐nucleotide polymorphisms (SNPs) in 111 North American grey wolves. Using these SNP data and individual‐level measurements of 12 environmental variables, we identified six ecotypes: West Forest, Boreal Forest, Arctic, High Arctic, British Columbia and Atlantic Forest. Next, we explored signals of selection across these wolf ecotypes through the use of three complementary methods to detect selection: FST/haplotype homozygosity bivariate percentilae, bayescan, and environmentally correlated directional selection with bayenv. Across all methods, we found consistent signals of selection on genes related to morphology, coat coloration, metabolism, as predicted, as well as vision and hearing. In several high‐ranking candidate genes, including LEPR, TYR and SLC14A2, we found variation in allele frequencies that follow environmental changes in temperature and precipitation, a result that is consistent with local adaptation rather than genetic drift. Our findings show that local adaptation can occur despite gene flow in a highly mobile species and can be detected through a moderately dense genomic scan. These patterns of local adaptation revealed by SNP genotyping likely reflect high fidelity to natal habitats of dispersing wolves, strong ecological divergence among habitats, and moderate levels of linkage in the wolf genome.
Green Transformational Leadership and Green Performance: The Mediation Effects of Green Mindfulness and Green Self-Efficacy

No prior literature explores the influence of green transformational leadership on green performance, thus, this study develops a novel research framework to fill the research gap. This study investigates the influence of green transformational leadership on green performance and discusses the mediation effects of green mindfulness and green self-efficacy by means of structural equation modeling (SEM). The results indicate that green transformational leadership positively influences green mindfulness, green self-efficacy, and green performance. Moreover, this study demonstrates that the positive relationship between green transformational leadership and green performance is partially mediated by the two mediators: green mindfulness and green self-efficacy. It means that green transformational leadership can not only directly affect green performance positively but also indirectly affect it positively through green mindfulness and green self-efficacy. Therefore, firms need to raise their green transformational leadership, green mindfulness, and green self-efficacy to increase their green performance.
Using Artificial Intelligence Techniques in Computer Graphics

The object of this paper is to prove that the use of artificial intelligence techniques in computer graphics can greatly improve the obtained results. Improvements in three areas of computer graphics are presented in the paper: in scene modelling, where declarative modelling techniques can greatly improve the designer’s work ; in scene understanding, where the use of heuristic search and strategy games techniques allows the user to well understand a scene by means of a virtual camera moving around the scene; in Monte Carlo radiosity techniques where the use of heuristic search permits to automatically estimate the complexity of a region of the scene to be rendered and so to refine the processing of complex regions in order to obtain more accurate images.
Genome-Scale Analysis of Translation Elongation with a Ribosome Flow Model

We describe the first large scale analysis of gene translation that is based on a model that takes into account the physical and dynamical nature of this process. The Ribosomal Flow Model (RFM) predicts fundamental features of the translation process, including translation rates, protein abundance levels, ribosomal densities and the relation between all these variables, better than alternative (‘non-physical’) approaches. In addition, we show that the RFM can be used for accurate inference of various other quantities including genes' initiation rates and translation costs. These quantities could not be inferred by previous predictors. We find that increasing the number of available ribosomes (or equivalently the initiation rate) increases the genomic translation rate and the mean ribosome density only up to a certain point, beyond which both saturate. Strikingly, assuming that the translation system is tuned to work at the pre-saturation point maximizes the predictive power of the model with respect to experimental data. This result suggests that in all organisms that were analyzed (from bacteria to Human), the global initiation rate is optimized to attain the pre-saturation point. The fact that similar results were not observed for heterologous genes indicates that this feature is under selection. Remarkably, the gap between the performance of the RFM and alternative predictors is strikingly large in the case of heterologous genes, testifying to the model's promising biotechnological value in predicting the abundance of heterologous proteins before expressing them in the desired host.
Vorinostat enhances the anticancer effect of oxaliplatin on hepatocellular carcinoma cells

Oxaliplatin‐based systemic chemotherapy has been proposed to have efficacy in hepatocellular carcinoma (HCC). We investigated the combination of vorinostat and oxaliplatin for possible synergism in HCC cells. SMMC7721, BEL7402, and HepG2 cells were treated with vorinostat and oxaliplatin. Cytotoxicity assay, tumorigenicity assay in vitro, cell cycle analysis, apoptosis analysis, western blot analysis, animal model study, immunohistochemistry, and quantitative PCR were performed. We found that vorinostat and oxaliplatin inhibited the proliferation of SMMC7721, BEL7402, and HepG2 cells. The combination index (CI) values were all <1, and the dose‐reduction index values were all greater than 1 in the three cell lines, indicating a synergistic effect of combination of the two agents. Coadministration of vorinostat and oxaliplatin induced G2/M phase arrest, triggered caspase‐dependent apoptosis, and decreased tumorigenicity both in vitro and in vivo. Vorinostat suppressed the expression of BRCA1 induced by oxaliplatin. In conclusion, cotreatment with vorinostat and oxaliplatin exhibited synergism in HCC cells. The combination inhibited cell proliferation and tumorigenicity both in vitro and in vivo through induction of cell cycle arrest and apoptosis. Our results predict that a combination of vorinostat and oxaliplatin may be useful in the treatment of advanced HCC.
Nursing, caring, and complexity science : for human-environment well-being

This book explores nursing and complexity science, and investigates how they relate in research, education, and practice. The book examines the best methods for using complex systems, and the contributing authors are experts drawn from nursing, sociology, informatics, and mathematics. Each is actively involved in applying complexity science to diverse populations in various settings (especially, in terms of nursing, chronic care, health care organizations, and community health networks). Each chapter includes a response written by a nursing scholar, administrator, or practitioner, focusing on chapter concepts relevant to the complex systems seen in nursing. The book includes models that relate how these concepts can be used in practice, management, education, and research-from micro to macro scales. The first of its kind, this book demonstrates the potential of complex systems perspectives to understand and improve nursing and health care research, education, and practice.
The Alignment Api 4.0 1

Alignments represent correspondences between entities of two ontologies. They are produced from the ontologies by ontology matchers. In order for matchers to exchange alignments and for applications to manipulate matchers and alignments, a minimal agreement is necessary. The Alignment API provides abstractions for the notions of network of ontologies, alignments and correspondences as well as building blocks for manipulating them, such as matchers, evaluators, renderers and parsers. We recall the building blocks of this API and present here the version 4 of the Alignment API through some of its new features: ontology proxys, the expressive alignment language EDOAL and evaluation primitives.
Quantization in Task-Driven Sensing and Distributed Processing

Quantization is the mapping of continuous quantities into discrete quantities, an operation far more general and flexible than the ubiquitous example of analog-to-digital conversion of scalar amplitude values. By appropriate choice of distortion measures and transmission constraints, quantization can incorporate signal processing such as statistical classification, estimation, and modeling. We here survey several approaches to incorporating such tasks into the quantization and possible extensions to distributed signal processing
Design of Greenhouse Gas Observing Systems ( WP 2 . 15 )

18.2. 1 Model Development within SDGVM The primary Dynamic Global Vegetation Model (DGVM) for estimating that we are making use of for flux estimation is the Sheffield DGVM (SDGVM). This year’s major SDGVM model developments have been concerned with tracing the dynamics of individual functional type cohorts and a completely new representation of root and soil carbon dynamics. Of particular relevance to this project are:
New approaches in psychological measurement

By reading, you can know the knowledge and things more, not only about what you get from people to people. Book will be more trusted. As this new approaches in psychological measurement, it will really give you the good idea to be successful. It is not only for you to be success in certain life you can be successful in everything. The success can be started by knowing the basic knowledge and do actions.
Performance of young adult cannabis users on neurocognitive measures of impulsive behavior and their relationship to symptoms of cannabis use disorders

Recent studies suggest that abstinent cannabis users show deficits on neurocognitive laboratory tasks of impulsive behavior. But results are mixed, and less is known on the performance of non-treatment-seeking, young adult cannabis users. Importantly, relationships between performance on measures of impulsive behavior and symptoms of cannabis addiction remain relatively unexplored. We compared young adult current cannabis users (CU, n = 65) and nonusing controls (NU, n = 65) on several laboratory measures of impulsive behavior, as well as on a measure of episodic memory commonly impacted by cannabis use. The CU group performed more poorly than the NU group on the Hopkins Verbal Learning Test–Revised Total Immediate Recall and Delayed Recall. No significant differences were observed on the measures of impulsive behavior (i.e., Iowa Gambling Task, IGT; Go–Stop Task; Monetary Choice Questionnaire; Balloon Analogue Risk Task). We examined relationships between neurocognitive performance and symptoms of cannabis use disorder symptoms (Diagnostic and Statistical Manual of Mental Disorders–Fourth Edition, DSM–IV CUD) among the CU group, which revealed that poorer IGT performance was associated with more symptoms of DSM–IV CUD. Our results show poorer memory performance among young adult cannabis users than among healthy controls, but no differences on measures of impulsive behavior. However, performance on a specific type of impulsive behavior (i.e., poorer decision making) was associated with more cannabis use disorder symptoms. These results provide preliminary evidence to suggest that decision-making deficits may be more strongly associated with problems experienced from cannabis use, rather than solely being a consequence of cannabis use, per se. This publication was supported by Grants K23DA023560 and R01DA031176 (PI: Gonzalez) and F31DA032244 (PI: Schuster) from the National Institute on Drug Abuse (NIDA), as well as P01 CA098262 (PI: Mermelstein) from the National Cancer Institute (NCI). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health.
Scattering by many small particles and creating materials with a desired refraction coefficient

Combining an asymptotic method and computational modelling the authors propose a method for creating materials with the desired electrodynamical characteristics, in particular, with a desired refraction coefficient. The problem of wave scattering by many small particles is solved asymptotically under the assumptions ka > a, where a is the size of the particles and d is the distance between the neighbouring particles. On the wavelength one may have many small particles. Impedance boundary conditions are assumed on the boundaries of small particles. The results of numerical simulation show good agreement with the theory. Constructive conclusions are given for creating materials with a desired refraction coefficient on the basis of the obtained numerical results. Engineering realisation of the theory is of practical interest.
Orbital schwannoma: histopathologic correlation with magnetic resonance imaging.

CASE REPORT A 45-year-old man presented with an orbital tumour that on MRI was most consistent with a hemangioma. Histopathologic examination disclosed an orbital schwannoma, with cystic and mucinous degeneration complicating radiologic interpretation. COMMENTS An array of ancillary studies including orbital ultrasonography may be useful in substantiating the diagnosis preoperatively.
Hip resurfacing arthroplasty: The evolution of contemporary designs

Abstract Metal-on-metal hip resurfacing is considered by many as the most significant recent development in hip arthroplasty. It preserves proximal femoral bone stock, optimizes stress transfer to the proximal femur, and offers inherent stability and optimal range of movement. The early results of hip resurfacing in the 1970s and 1980s were poor and the procedure was largely abandoned by the mid-1980s. The expectation that these prostheses would be easy to revise was not often fulfilled. The large diameter of the articulation combined with thin polyethylene cups or liners resulted in accelerated wear and the production of large volumes of biologically active particulate debris, leading to bone loss and implant loosening. Failure has been attributed to other factors, mainly avascular necrosis of the femoral head. However, this concern has not been confirmed by retrieval studies. The failure of early hip resurfacings was essentially a consequence of the use of inappropriate materials, poor implant design, inadequate instrumentation, and crude surgical technique. It was not an inherent problem with the procedure itself. The renaissance of metal-on-metal articulations for total hip arthroplasty enabled the introduction of new hip resurfacings and most of the major implant manufacturers have already introduced such systems. Early results are encouraging and complications commonly seen in the 1970s and 1980s, such as early implant loosening and femoral neck fracture, now appear to be rare. Whilst early results should be regarded with caution, modern metal-on-metal hip resurfacing potentially offers the ultimate bone preservation and restoration of function in appropriately selected young patients.
Genetic Variation of Highly Pathogenic H5N1 Avian Influenza Viruses in Vietnam Shows Both Species-Specific and Spatiotemporal Associations

SUMMARY. Domestic poultry act as a reservoir for persistent H5N1 endemicity in Vietnam, and the circulation of poultry flocks across farms and to market is thought to drive the spatial movement and evolution of avian influenza viruses. Using a dataset of complete or nearly full genomic sequences from highly pathogenic H5N1 avian influenza viruses collected in domestic poultry in Vietnam from 2003 to 2007, we explore potential differences in genetic characteristics according to species of isolation and the spatiotemporal characteristics of the viruses. Clustering algorithms and ANOVA indicate that H5N1 viruses in Vietnam show differences in the amount of genetic change that chicken viruses experience as compared to duck viruses, with duck viruses showing higher rates of molecular evolution on all eight of influenza's gene segments. There also exist distinct patterns of genetic differentiation according to the year in which they were isolated. These findings suggest that genetic evolution of avian influenza viruses is continuous through time but could also be mediated by the species in which the viruses occur, information that has implications for prevention efforts.