Miracle-dz/UniFAR-FTUs huggingface dataset:
Early intervention for adolescents with borderline personality disorder using cognitive analytic therapy: randomised controlled trial

Background No accepted intervention exists for borderline personality disorder presenting in adolescence. Aims To compare the effectiveness of up to 24 sessions of cognitive analytic therapy (CAT) or manualised good clinical care (GCC) in addition to a comprehensive service model of care. Method In a randomised controlled trial, CAT and GCC were compared in out-patients aged 15–18 years who fulfilled two to nine of the DSM–IV criteria for borderline personality disorder. We predicted that, compared with the GCC group, the CAT group would show greater reductions in psychopathology and parasuicidal behaviour and greater improvement in global functioning over 24 months. Results Eighty-six patients were randomised and 78 (CAT n=41; GCC n=37) provided follow-up data. There was no significant difference between the outcomes of the treatment groups at 24 months on the pre-chosen measures but there was some evidence that patients allocated to CAT improved more rapidly. No adverse effect was shown with either treatment. Conclusions Both CAT and GCC are effective in reducing externalising psychopathology in teenagers with sub-syndromal or full-syndrome bipolar personality disorder. Larger studies are required to determine the specific value of CAT in this population.
Two Approaches for Multilingual Question Answering: Merging Passages vs. Merging Answers

One major problem in multilingual Question Answering (QA) is the integration of information obtained from different languages into one single ranked list. This paper proposes two different architectures to overcome this problem. The first one performs the information merging at passage level, whereas the second does it at answer level. In both cases, we applied a set of traditional merging strategies from cross-lingual information retrieval. Experimental results evidence the appropriateness of these merging strategies for the task of multilingual QA, as well as the advantages of multilingual QA over the traditional monolingual approach.
A C-Function For Non-Supersymmetric Attractors

We present a c-function for spherically symmetric, static and asymptotically flat solutions in theories of four-dimensional gravity coupled to gauge fields and moduli. The c-function is valid for both extremal and non-extremal black holes. It monotonically decreases from infinity and in the static region acquires its minimum value at the horizon, where it equals the entropy of the black hole. Higher dimensional cases, involving p-form gauge fields, and other generalisations are also discussed.
Fuzzy Association Rules : new method and implementation

© 2014. The Authors. Published under Af o Asian Journal of Science and Technology www.aajst. com 26 Amir Ebrahimzadeh Sama technical and vocational training college, Islamic Azad University, Mashhad branch, Mashhad, Iran Abstract due to increasing use of huge databases , mining practical information and useful knowledge from transactions is evolving into an important area. Most data mining methods focuses on relationship among transactions. Many algorithms have been proposed to find association rules in databases with either binary or quantitative attributes. One of these approaches is fuzzy association rules mining. Fuzzy Apriori and its different variations are the popular fuzzy association rule mining (ARM) algorithms available today. Like the crisp version of Apriori, fuzzy Apriori is a very slow and inefficient algorithm for very large datasets. Hence ,in this paper, we introduce a novel technique , called FCT, for mining fuzzy association rules . Existing method discovers fuzzy association rules by scaning the database once, and performing three tasks simultaneously . First , compute the fuzzy supports of candidate 1itemsets and then generate large 1-itemsets.Second , divide database into multiple cluster tables ,such that transaction with length k , fall into cluster table k.
Mechanisms of ibrutinib resistance in chronic lymphocytic leukaemia and non‐Hodgkin lymphoma

Bruton tyrosine kinase (BTK), a mediator of B‐cell receptor (BCR) signalling, has been implicated in the pathogenesis of chronic lymphocytic leukaemia (CLL) and other B‐cell malignancies. Ibrutinib is an orally bioavailable and highly specific BTK inhibitor that was recently approved for treatment of patients with recurrent CLL and mantle cell lymphoma (MCL). In addition, ibrutinib has shown efficacy in subsets of patients with diffuse large B cell lymphoma (DLBCL) and Waldenstrom macroglobulinaemia (WM). However, despite ibrutinib's activity in multiple B‐cell malignancies, cases of primary and secondary resistance have emerged. The overall reported frequency of resistance is low, but follow‐up in many trials was short, and we predict that the incidence of observed resistance will increase as clinical use outside clinical trials expands over time. Mutations within BTK have been described and clearly interfere with drug binding; however, there are also emerging alternative mechanisms that bypass BTK entirely and offer new opportunities for other targeted agents. Improved understanding of mechanisms of primary and secondary resistance is essential to developing appropriate therapeutic strategies to both prevent and address resistance. This review provides a comprehensive analysis of ibrutinib resistance in CLL, MCL, DLBCL and WM and considers potential strategies for further study.
Non‐motor symptoms in Parkinson’s disease

Although still considered a paradigmatic movement disorder, Parkinson’s disease (PD) is associated with a broad spectrum of non‐motor symptoms. These include disorders of mood and affect with apathy, anhedonia and depression, cognitive dysfunction and hallucinosis, as well as complex behavioural disorders. Sensory dysfunction with hyposmia or pain is almost universal, as are disturbances of sleep–wake cycle regulation. Autonomic dysfunction including orthostatic hypotension, urogenital dysfunction and constipation is also present to some degree in a majority of patients. Whilst overall non‐motor symptoms become increasingly prevalent with advancing disease, many of them can also antedate the first occurrence of motor signs – most notably depression, hyposmia or rapid eye movement sleep behaviour disorder (RBD). Although exact clinicopathological correlations for most of these non‐motor features are still poorly understood, the occurrence of constipation, RBD or hyposmia prior to the onset of clinically overt motor dysfunction would appear consistent with the ascending hypothesis of PD pathology proposed by Braak and colleagues. Screening these early non‐motor features might, therefore, be one approach towards early ‘preclinical’ diagnosis of PD. This review article provides an overview of the clinical spectrum of non‐motor symptoms in PD together with a brief review of treatment options.
Improving Adherence to Otitis Media Guidelines With Clinical Decision Support and Physician Feedback

OBJECTIVE: To assess the effects of electronic health record–based clinical decision support (CDS) and physician performance feedback on adherence to guidelines for acute otitis media (AOM) and otitis media with effusion (OME). METHODS: We conducted a factorial-design cluster randomized trial with primary care practices (n = 24) as the unit of randomization and visits as the unit of analysis. Between December 2007 and September 2010, data were collected from 139 305 otitis media visits made by 55 779 children aged 2 months to 12 years. When activated, the CDS system provided guideline-based recommendations individualized to the patient’s history and presentation. Monthly physician feedback reported adherence to guideline-based care, changes over time, and comparisons to others in the practice and network. RESULTS: Comprehensive care (all recommended guidelines were adhered to) was accomplished for 15% of AOM and 5% of OME visits during the baseline period. The increase from baseline to intervention periods in adherence to guidelines was larger for CDS compared with non-CDS visits for comprehensive care, pain treatment, adequate diagnostic evaluation for OME, and amoxicillin as first-line therapy for AOM. Although performance feedback was associated with improved antibiotic prescribing for AOM and pain treatment, the joint effects of CDS and feedback on guideline adherence were not additive. There was marked variation in use of the CDS system, ranging from 5% to 45% visits across practices. CONCLUSIONS: Clinical decision support and performance feedback are both effective strategies for improving adherence to otitis media guidelines. However, combining the 2 interventions is no better than either delivered alone.
The Actual Versus Idealized Self: Exploring Responses to Feedback About Implicit Bias in Health Professionals

Purpose Implicit bias can adversely affect health disparities. The implicit association test (IAT) is a prompt to stimulate reflection; however, feedback about bias may trigger emotions that reduce the effectiveness of feedback interventions. Exploring how individuals process feedback about implicit bias may inform bias recognition and management curricula. The authors sought to explore how health professionals perceive the influence of the experience of taking the IAT and receiving their results. Method Using constructivist grounded theory methodology, the authors conducted semistructured interviews with 21 pediatric physicians and nurses at the Schulich School of Medicine and Dentistry, Western University, Ontario, Canada, from September 2015 to November 2016 after they completed the mental illness IAT and received their result. Data were analyzed using constant comparative procedures to work toward axial coding and development of an explanatory theory. Results When provided feedback about their implicit attitudes, participants described tensions between acceptance and justification, and between how IAT results relate to idealized and actual personal and professional identity. Participants acknowledged desire for change while accepting that change is difficult. Most participants described the experience of taking the IAT and receiving their result as positive, neutral, or interesting. Conclusions These findings contribute to emerging understandings of the relationship between emotions and feedback and may offer potential mediators to reconcile feedback that reveals discrepancies between an individual’s actual and idealized identities. These results suggest that reflection informed by tensions between actual and aspirational aspects of professional identity may hold potential for implicit bias recognition and management curricula.
Creation of artificial ionospheric layers using high‐power HF waves

We report the first evidence of artificial ionospheric plasmas reaching sufficient density to sustain interaction with a high‐power HF pump beam produced by the 3.6 MW High‐Frequency Active Auroral Program (HAARP) transmitter in Gakona, Alaska. The HF‐driven ionization process is initiated near the 2nd electron gyroharmonic at 220 km altitude in the ionospheric F region. Once the artificial plasma reaches sufficient density to support interaction with the transmitter beam it rapidly descends as an ionization wave to ∼150 km altitude. Although these initial artificial layers appear to be dynamic and highly structured, this new ability to produce significant artificial plasma in the upper atmosphere opens the door to a new regime in ionospheric radio wave propagation where transmitter‐produced plasmas dominate over the natural ionospheric plasma and may eventually be employed as active components of communications, radar, and other systems.
Os técnicos de saúde e a sexualidade dos doentes oncológicos: Atitudes, crenças e intenções comportamentais

Nos dias de hoje, a sexualidade ainda constitui um tema controverso e polemico, principalmente, quando associada a pessoas debilitadas e/ou incapacitadas, como e o caso dos doentes oncologicos. Desta forma, estes doentes continuam sem receber a devida informacao e esclarecimento acerca desta tematica, vinda dos profissionais que lhes prestam os cuidados de saude. Esta investigacao trata-se de um estudo exploratorio, que visa descrever as atitudes, crencas e intencoes comportamentais dos tecnicos de saude face a sexualidade dos doentes oncologicos. Os participantes (85% do sexo feminino) formam uma amostra de 46 sujeitos que acederam participar. Foi construido um questionario anonimo e confidencial, constituido por 28 itens, a que os sujeitos respondiam numa escala tipo Likert e, tres questoes de caracter aberto. A analise dos resultados evidencia que os tecnicos de saude apresentam atitudes e crencas favoraveis perante a sexualidade dos doentes em questao e intencoes comportamentais neutras face ao mesmo objecto de estudo.
Tandem cuff artificial urinary sphincter as a salvage procedure following failed primary sphincter placement for the treatment of post-prostatectomy incontinence.

PURPOSE Management of post-artificial urinary sphincter (AUS) urethral atrophy can be difficult for the treating physician, yielding unsatisfactory results for the patient. As with many incontinence procedures, initial results are generally encouraging. We determined the durability and success of tandem cuff placement for urethral atrophy following AUS placement. MATERIALS AND METHODS We reviewed the records of 18 patients with a mean age 74 years who underwent tandem AUS placement from 1994 to 2001. Mean followup was 3.3 years. All patients originally underwent AUS placement for post-prostatectomy stress urinary incontinence and they had subsequent incontinence secondary to urethral atrophy. Adjuvant radiation in 3 cases, hormone therapy in 3, cuff size and pressure, and multiple continence procedures prior to tandem cuff placement in 5 were evaluated as risk factors for cuff erosion. Long-term followup was obtained through office examination and telephone interview using a standardized questionnaire regarding voiding habits and satisfaction. RESULTS Following tandem cuff placement mean +/- SD pad use daily decreased from 4.3 +/- 0.35 (median 3) to 1.6 +/- 0.42 (median 1) (p <0.0001). Overall 10 of the 18 patients (56%) needed 1 pad or less daily, 16 (88%) would have the tandem cuff placed again and 17 (94%) would recommend the procedure. Median subjective improvement and satisfaction was 4.7 and 4.0, respectively, on a scale of 0 to 5. Reoperation was required for cuff leakage in 1 case and cuff erosion in 2. One patient with erosion had 3 prior AUS revisions, including placement of a 71 to 80 cc balloon reservoir. CONCLUSIONS Placement of tandem urethral cuff as a salvage procedure for recurrent stress urinary incontinence provides marked sustained improvement in leakage and overall high patient satisfaction in the difficult setting of urethral atrophy.
Understanding and Supporting Sensemaking in Collaborative Web Search

While there has been some research on sensemaking in individual information seeking, there is little understanding of sensemaking in collaborative information seeking tasks, such as collaborative Web search. We conducted a study of users’ sensemaking in collaborative Web search tasks performed using SearchTogether. Based on findings of this study, we designed, implemented, and evaluated a tool, CoSense, to enhance sensemaking for collaborative search tasks. The results of our evaluation of CoSense provide insight into how people collaboratively make sense of information and what design features can help them.
The composability problem of events and threads in distributed systems

Event-driven programming has been a relatively hot topic in distributed systems development. Having worked on these systems for years, we now believe that it is not the best choice. Besides the well-known “stack ripping” problem, we argue that it greatly influences the composability of software modules. Preemptive threads are also short of composability because of data-races and locks. Lacking of composability can result in systems with little vitality. Cooperative threading (or coroutine), on the contrary, is almost free of this problem, so we advocate it as the primary concurrency model for most distributed systems.
Effect of Surgical Portosystemic Shunt on Prevalence of Minimal Hepatic Encephalopathy in Children With Extrahepatic Portal Venous Obstruction: Assessment by Magnetic Resonance Imaging and Psychometry

Objective: The aim of this study was to evaluate the effect of surgical portosystemic shunt (PSS) on the prevalence of minimal hepatic encephalopathy (MHE) in patients with extrahepatic portal venous obstruction. Patients and Methods: Forty-two children with extrahepatic portal venous obstruction (17 with surgical PSS, 25 without surgical shunt) and 20 healthy children were evaluated with blood ammonia (BA), psychometry, 1H magnetic resonance spectroscopy, critical flicker frequency (CFF), and diffusion tensor imaging. Serum tumor necrosis factor-α and interleukin-6 were measured in 10 patients and 8 controls. Results: Patients with surgical PSS had significantly higher BA and glutamine/creatine on 1H-MR spectroscopy than those without surgical shunt. Both groups of patients had significantly higher BA and glutamate/creatine than controls. Myoinositol was reduced in patients with surgical PSS. MHE was present in 41% cases with and 32% cases without surgical PSS (p-ns). Raised mean diffusivity on diffusion tensor imaging signifying low-grade cerebral edema was seen only in MHE cases. Patients had significantly higher serum tumor necrosis factor-α and interleukin-6 levels than controls. CFF was abnormal in 5 of 15 patients with MHE. Conclusions: Patients with surgical PSS have significantly higher BA and Glx/creatine than those without surgical PSS. MHE prevalence was higher in surgically shunted than in the nonshunted patients, but the difference was not significant. Cerebral edema is present in patients with MHE. CFF has limited diagnostic utility for MHE in children.
Variation of DAT1 VNTR Alleles and Genotypes Among Old Ethnic Groups in Mesopotamia to the Oxus Region

ABSTRACT Variation of a VNTR in the DAT1 gene in seven ethnic groups of the Middle East was used to infer the history and affinities of these groups. The populations consisted of Assyrian, Jewish, Zoroastrian, Armenian, Turkmen, and Arab peoples of Iran, Iraq, and Kuwait. Three hundred forty subjects from these seven ethnic groups were screened for DAT1. DAT1 VNTR genotyping showed 3, 6, 7, 8, 9, 10, 11, and 12 alleles in the samples. Analysis of these data revealed differentiation and relationship among the populations. In this region, which covers an area of 2–2.5 million km2, the influence of geography and especially of linguistic characteristics has had potentially major effects on differentiation. Religion also has played a major role in imposing restrictions on some ethnic groups, who as a consequence have maintained their community. Overall, these ethnic groups showed greater heterogeneity compared to other populations.
Generational Changes, Political Stagnation, and the Evolving Dynamics of Religion and Politics in Senegal

Religious institutions, in the form of Muslim Sufi orders, have been an integral feature of Senegal's stable and relatively democratic socio-political system. Over the course of the 1990s, this system has experienced strains due to two factors: generational changes and a crisis of legitimacy of the political system. This has resulted in three potentially significant types of phenomena: 1) the growing (though still limited) appeal of reformist Islamic ideology; 2) contestatory movements for leadership of the orders; and 3) succession struggles within religious families. This article examines these three trends by means of a discussion of the Muslim students' movement at the University Cheikh An-ta Diop de Dakar, the Hizbut-Tarqiyyah movement in the Mouride Order, and the Moustarchidine movement which has resulted in a schism in the Sy Tijan family. While the socio-political system remains well in place, its evolution is likely to be shaped by these dynamics.
Improving Dorsal Stream Function in Dyslexics by Training Figure/Ground Motion Discrimination Improves Attention, Reading Fluency, and Working Memory

There is an ongoing debate about whether the cause of dyslexia is based on linguistic, auditory, or visual timing deficits. To investigate this issue three interventions were compared in 58 dyslexics in second grade (7 years on average), two targeting the temporal dynamics (timing) of either the auditory or visual pathways with a third reading intervention (control group) targeting linguistic word building. Visual pathway training in dyslexics to improve direction-discrimination of moving test patterns relative to a stationary background (figure/ground discrimination) significantly improved attention, reading fluency, both speed and comprehension, phonological processing, and both auditory and visual working memory relative to controls, whereas auditory training to improve phonological processing did not improve these academic skills significantly more than found for controls. This study supports the hypothesis that faulty timing in synchronizing the activity of magnocellular with parvocellular visual pathways is a fundamental cause of dyslexia, and argues against the assumption that reading deficiencies in dyslexia are caused by phonological deficits. This study demonstrates that visual movement direction-discrimination can be used to not only detect dyslexia early, but also for its successful treatment, so that reading problems do not prevent children from readily learning.
A System for Multi-Modal Assessment of Cardiovascular Parameters-Design and Measurements

This research introduces a novel multi-modal vital parameter measurement system and with some measurements taken. The system is able to accurately and simultaneously measure a single channel Electrocardiogram (ECG), four Photoplethysmograms (PPG), the pressure in both ears, as well as the broadband, time resolved thorax bioimpedance (ICG). The designed measurement system is based on a System on Chip (SoC) FieldProgrammable Gate Array (FPGA) and a Texas Instruments analog front end (ADS1298) and in principle is in compliance with the IEC60601-1 safety requirements. ECG, PPG, ICG and in-ear measurements have a temporal resolution of about 1 ms. The measured time resolved impedance curve in connection with ECG and PPG and are digitally processed and analyzed in MathWorks MATLAB. Estimates of Stroke Volume (SV), Cardiac Output (CO), Pulse Arrival Time (PAT), Pulse Wave Velocity (PWV), Heart Rate Variability (HRV) and Respiration Rate (RR) are calculated from the different measurements.