Miracle-dz/UniFAR-FTUs huggingface dataset:
Using conversational data in the treatment of pragmatic disorder in children

While pragmatic disorders in children have received increasing recogni tion in recent years, therapists still lack tools for the assessment of children displaying such disorders. This paper describes an approach to assessment which is based on the analysis of samples of conversational data. A number of categories of pragmatic 'error' are identified. The system is illustrated by a brief case study. Because of inevitable problems with inter-tester reliability, it is suggested that this approach is best used for identifying areas for remediation, and for reassessment in order to evaluate therapy.
Real-case simulations of aerosol–cloud interactions in ship tracks over the Bay of Biscay

Abstract. Ship tracks provide an ideal test bed for studying aerosol–cloud interactions (ACIs) and for evaluating their representation in model parameterisations. Regional modelling can be of particular use for this task, as this approach provides sufficient resolution to resolve the structure of the produced track including their meteorological environment whilst relying on the same formulations of parameterisations as many general circulation models. In this work we simulate a particular case of ship tracks embedded in an optically thin stratus cloud sheet which was observed by a polar orbiting satellite at 12:00 UTC on 26 January 2003 around the Bay of Biscay. The simulations, which include moving ship emissions, show that the model is indeed able to capture the structure of the track at a horizontal grid spacing of 2 km and to qualitatively capture the observed cloud response in all simulations performed. At least a doubling of the cloud optical thickness was simulated in all simulations together with an increase in cloud droplet number concentration by about 40 cm−3 (300%) and decrease in effective radius by about 5 μm (40%). Furthermore, the ship emissions lead to an increase in liquid water path in at least 25% of the track regions. We are confident in the model's ability to capture key processes of ship track formation. However, it was found that realistic ship emissions lead to unrealistic aerosol perturbations near the source regions within the simulated tracks due to grid-scale dilution and homogeneity. Combining the regional-modelling approach with comprehensive field studies could likely improve our understanding of the sensitivities and biases in ACI parameterisations, and could therefore help to constrain global ACI estimates, which strongly rely on these parameterisations.
Skew detection and compensation for Internet audio applications

Long lived audio streams, such as music broadcasts, and small differences in clock rates lead to buffer underflow or overflow events in receiving applications that manifest themselves as audible interruptions. We present a low complexity algorithm for detecting clock skew in network audio applications that function with local clocks and in the absence of a synchronization mechanism. A companion algorithm to perform skew compensation is also presented. The compensation algorithm utilises the temporal redundancy inherent in audio streams to make inaudible playout adjustments. Both algorithms have been implemented in a simulator and in a network audio application. They perform effectively over the range of observed clock rate differences and beyond.
Establishing a complementary diagnostic for anti-PD-1 immune checkpoint inhibitor therapy

The role of tumor PD-L1 expression was investigated across the nivolumab clinical development program. Phase III nivolumab trials have shown that patients with tumors not expressing PD-L1 may benefit; therefore, testing is not required to select patients for therapy. The Dako PD-L1 IHC 28-8 pharmDx assay may be used to determine tumor PD-L1 expression as a complementary and informative test.
Gemtuzumab Ozogamicin Versus Best Supportive Care in Older Patients With Newly Diagnosed Acute Myeloid Leukemia Unsuitable for Intensive Chemotherapy: Results of the Randomized Phase III EORTC-GIMEMA AML-19 Trial.

PURPOSE To compare single-agent gemtuzumab ozogamicin (GO) with best supportive care (BSC) including hydroxyurea as first-line therapy in older patients with acute myeloid leukemia unsuitable for intensive chemotherapy. PATIENTS AND METHODS In this trial, patients at least 61 years old were centrally randomized (1:1) to receive either a single induction course of GO (6 mg/m(2) on day 1 and 3 mg/m(2) on day 8) or BSC. Patients who did not progress after GO induction could receive up to eight monthly infusions of the immunoconjugate at 2 mg/m(2). Randomization was stratified by age, WHO performance score, CD33 expression status, and center. The primary end point was overall survival (OS) by intention-to-treat analysis. RESULTS A total of 237 patients were randomly assigned (118 to GO and 119 to BSC). The median OS was 4.9 months (95% CI, 4.2 to 6.8 months) in the GO group and 3.6 months (95% CI, 2.6 to 4.2 months) in the BSC group (hazard ratio, 0.69; 95% CI, 0.53 to 0.90; P = .005); the 1-year OS rate was 24.3% with GO and 9.7% with BSC. The OS benefit with GO was consistent across most subgroups, and was especially apparent in patients with high CD33 expression status, in those with favorable/intermediate cytogenetic risk profile, and in women. Overall, complete remission (CR [complete remission] + CRi [CR with incomplete recovery of peripheral blood counts]) occurred in 30 of 111 (27%) GO recipients. The rates of serious adverse events (AEs) were similar in the two groups, and no excess mortality from AEs was observed with GO. CONCLUSION First-line monotherapy with low-dose GO, as compared with BSC, significantly improved OS in older patients with acute myeloid leukemia who were ineligible for intensive chemotherapy. No unexpected AEs were identified and toxicity was manageable.
Information technology into education: towards a critical perspective 1

The starting point for this paper is that the use and discussion of information technology (IT) in education is uncritical. The dominant emphasis is on more being inherently better; and questions about the relationship of the technology to teaching and learning ‐ the sorts of questions which educationalists have traditionally asked about educational innovations ‐ have not featured prominently on the agenda. Rather, problems and limitations have been played down in the emphasis on the technological hard and software. This paper makes an initial contribution to what we see as the need: for ethnographic, classroom based research on IT in education using the interactionist model; to locate IT in education in its broader social, historical and cultural setting; to dismantle the technoromantic rhetoric or theology of IT in education, and to replace it with a more balanced and realistic assessment of its strengths and shortcomings; to develop a range of critical and analytical concepts to move us towards a theor.
Interactive Disambiguation of Natural Language Input: a Methodology and Two Implementatioons for French and English

1.3 Presentation As natural language is highly ambiguous even in restricted domains, interactive disambiguation is seen as a necessity for achieving more robust and user-friendly interactive systems, face-to-face translation systems and Dialogue-Based Machine Translation systems. We have proposed a methodology which distinguishes between two parts in a disambiguation module: an engine (languageand application-independent) and a lingware (languageand application-dependent). The engine is, thus, to be reused in the design of any disambiguation module. This paper presents the current state of our work, that is: an engine that has been used to design two interactive disambiguation modules, for French, and English.
Digital Papillomatosis in a Confined Beagle

Papillomavirus-induced papillomas were diagnosed on multiple digits of all 4 feet of a young Beagle. No other cutaneous or oral involvement was identified. Papillomavirus antigen was confirmed by im-munoperoxidase localization within keratinocyte nuclei. In addition to the typical basophilic intranuclear inclusions associated with papillomavirus infections, keratinocytes within the papillomas contained large, eosino-philic cytoplasmic inclusions that previously have been described in a Boxer with cutaneous lesions associated with a papillomavirus infection. The papillomas in this Beagle regressed completely within 2 months of the initial diagnosis.
Detecting obstructive sleep apnea in children by self-affine visualization of oximetry

Obstructive sleep apnea (OSA), characterized by cessations of breathing during sleep due to upper airway collapse, can affect the healthy growth and development of children. The gold standard for OSA diagnosis, polysomnography (PSG), is expensive and resource intensive, resulting in long waiting lists to perform a PSG.
China and Chinese, or Chingland and Chinglish?

A discussion of the sociolinguistic risks faced by the People's Republic of China in rapidly opening up to Western influences in both economic and linguistic terms. The writers argue against what they consider a currently over-enthusiastic adoption of English in which ‘a Westernised China … might more aptly, if ruefully, be referred to as “Chingland”. ’
Effect of Nitroprusside on Hydraulic Vascular Loads on the Right and Left Ventricle of Patients with Heart Failure

We studied the effect of nitroprusside on the hydraulic vascular load of the right and left ventricle in seven patients with severe left ventricular failure. At doses of 0.25–0.75,μg/kg/min, stroke volume increased progressively from 40.1 to 48.6 ml and left ventricular end-diastolic pressure decreased from 24.5 to 11.2 mm Hg. Accompanying this improvement in left ventricular performance were doserelated decreases in mean ventricular pressures, pulmonic and systemic resistances and the lower-frequency components of input impedance moduli. Characteristic impedance and both total and oscillatory external power were decreased in the pulmonic, but not the aortic, vasculature. In this class of patients, right ventricular unloading is a striking and direct effect of nitroprusside and may account, in part, for imnproved left ventricular performance through ventricular interdependence.
A Friend of Yours Is No Friend of Mine

The current research examined the novel hypothesis that a romantic partner’s same-sex friends can elicit jealousy by threatening people’s central role in their partner’s life. Thus, we expected that people whose partners were highly central to their lives would be particularly likely to experience jealousy toward their partner’s same-sex friends and that jealousy would be exacerbated when they had reason to doubt their partner’s commitment. Two studies supported our hypotheses. This research highlights how people alter perceptions of their partner’s broader social context to minimize perceived threats to their romantic relationships.
The mRNA of the Arabidopsis Gene FT Moves from Leaf to Shoot Apex and Induces Flowering

Day length controls flowering time in many plants. The day-length signal is perceived in the leaf, but how this signal is transduced to the shoot apex, where floral initiation occurs, is not known. In Arabidopsis, the day-length response depends on the induction of the FLOWERING LOCUS T (FT) gene. We show here that local induction of FT in a single Arabidopsis leaf is sufficient to trigger flowering. The FT messenger RNA is transported to the shoot apex, where downstream genes are activated. These data suggest that the FT mRNA is an important component of the elusive “florigen” signal that moves from leaf to shoot apex.
Cardiorenal and Humoral Properties of a Novel Direct Soluble Guanylate Cyclase Stimulator BAY 41-2272 in Experimental Congestive Heart Failure

Background—BAY 41-2272 is a recently introduced novel orally available agent that directly stimulates soluble guanylate cyclase (sGC) and sensitizes it to its physiological stimulator, nitric oxide. To date, its therapeutic actions in congestive heart failure (CHF) remain undefined. We characterized the cardiorenal actions of intravenous BAY 41-2272 in a canine model of CHF and compared it to nitroglycerin (NTG). Methods and Results—CHF was induced by rapid ventricular pacing for 10 days. Cardiorenal and humoral function were assessed at baseline and with administration of 2 doses of BAY 41-2272 (2 and 10 &mgr;g · kg−1 · min−1; n=8) or NTG (1 and 5 &mgr;g · kg−1 · min−1; n=6). Administration of 10 &mgr;g · kg−1 · min−1 BAY 41-2272 reduced mean arterial pressure (113±8 to 94±6 mm Hg;P <0.05), pulmonary artery pressure (29±2 to 25±2 mm Hg;P <0.05), and pulmonary capillary wedge pressure (25±2 to 20±2 mm Hg;P <0.05). Cardiac output (2.1±0.2 to 2.3±0.2 L/min;P <0.05) and renal blood flow (131±17 to 162±18 mL/min;P <0.05) increased. Glomerular filtration rate was maintained. There were no changes in plasma renin activity, angiotensin II, or aldosterone. NTG mediated similar hemodynamic changes and additionally decreased right atrial pressure and pulmonary vascular resistance. Conclusion—The new sGC stimulator BAY 41-2272 potently unloaded the heart, increased cardiac output, and preserved glomerular filtration rate without activation of the renin-angiotensin-aldosterone system in experimental CHF. These beneficial properties make direct sGC stimulation with BAY 41-2272 a promising new strategy for the treatment of cardiovascular diseases such as CHF.
Effects of hyperbaric therapy on liver morphofunctional of rabbits (Oryctolagus cuniculus) after hind limb ischemia-reperfusion injury

Aim: The objective of this research was to study and to prove the effectiveness of hyperbaric oxygen therapy (HBOT) starting time on liver morphofunctional changes after ischemia-reperfusion in the hind limb of rabbits. Materials and Methods: This research used a complete randomized design with 4 groups and 6 repetitions on each. After 6 h artery femoral is ligation, reperfusion was performed for 100 min (G1), HBOT for 90 min after 10 min reperfusion (G2), 10 min reperfusion (G3), and HBOT 90 min after 60 min reperfusion (G4). Then, all of the rabbits were sacrificed. The liver and blood were taken for histopathological changes examination as well as for measuring the level of aspartate aminotransferase (AST) and alanine aminotransferase (ALT). The statistical test using Kruskal–Wallis and Mann–Whitney showed that the score of degeneration, necrosis, and portal inflammation in groups without HBOT (G1 and G3) were not significantly different, as well as in group with HBOT (G2 and G4) (p>0.05). However, the scores of histopathological changes in G1 and G3 were significantly different from those in G2 and G4 (p<0.05). The levels of AST and ALT in the groups without hyperbaric therapy (G1 and G3) were not significantly different from those in the groups treated with hyperbaric therapy (G2 and G4) (p>0.05). Result:: Hind limb ischemia injury reperfusion can trigger damage for liver morphology, but not lead to liver dysfunction. Reperfusion can trigger increased activity of neutrophils, while neutrophil infiltration in the organ will lead to dysfunction. HBOT can inhibit the activity of neutrophils and the dysfunction of organs caused by ischemic reperfusion. Conclusion: HBOT for 90 min, both 10 and 60 min after the reperfusion, can protect hepatocytes from damage.
Defamation cases against historians

Defamation is the act of damaging another's reputation. According to recent legal research, defamation laws may be improperly used in many ways. Some of these uses profoundly affect the historian's work: first, when defamation laws protect reputations of states or nations as such; second, when they prevent legitimate criticism of officials; and, third, when they protect the reputations of deceased persons. The present essay offers two tests of these three abuses in legal cases where historians were defendants. The first test, a short worldwide survey, confirms the occurrence of all three abuses; the second test (an empirical analysis of twenty-one cases (1965-2000) from nine western European countries) the occurrence of the third abuse. Both tests touch on problems central to the historical profession: living versus deceased persons; facts versus opinions; legal versus historical truth; the relationship between human dignity, reputation, and privacy; the role of politicians, veterans, and Holocaust deniers as complainants; the problem of amnestied crimes. The second test-the results of which are based on verdicts, commentaries, and press articles, and presented in a synoptic table--looks closely into the complainants' and defendants' profiles, the allegedly defamatory statements themselves, and the verdicts. All statements deemed defamatory were about such contemporary events as World War II (particularly war crimes, collaboration, and resistance) and colonial wars. Both tests amount to two conclusions. The first one is about historians' professional rights and obligations: historians should make true, but privacy-sensitive or potentially offending, statements only when the public interest is served; otherwise, they should have a right to silence. The second conclusion concerns defamation itself: defamation cases and threats to sue in defamation have a chilling effect on the historical debate; they are often but barely veiled attempts at censorship. More than may be expected, historians land in the dock.2 Among the charges directed at them in their professional capacity, those involving defamation constitute a separate category. People critically portrayed in works of history may come to think that their reputation was tarnished and they seek redress in court. 1. I am grateful to my brother Paul De Baets, judge at the Court of Appeals of Antwerp, Belgium; Toby Mendel, Article 19's Head of Law Programme, London, United Kingdom; and Dr. Fred Jans
The limits to contemporary urban redevelopment ‘Doing’ entrepreneurial urbanism in Birmingham, Leeds and Manchester

Since the early 1970s there has been a series of economic and political transitions in the governance of the older industrialized cities of the global north. Grouped together, and commonly referred to as an entrepreneurial ‘turn’, this series of discrete but interlocking shifts in how the state intervenes and frames urban governance reveals much about the emergent geographies of neo‐liberalization. Nation states have codified the inter‐urban competition endemic in contemporary capitalism, building upon and reinforcing, rather than ameliorating, uneven economic development. Cities have thus been placed squarely in the front line of delivering national competitiveness. This is in sharp contrast to earlier representations of cities as relics of industrial glories and as financial drains on the nation's resources. In light of this changing portrayal, and building on earlier debates in CITY, this paper draws upon research in Birmingham, Leeds and Manchester to question how the meaning of ‘urban redevelopment’ has been re‐constituted in recent years, and in doing so it draws attention to what this might mean for issues of rights to the city.
The Gastrin-releasing Peptide Receptor Is Rapidly Phosphorylated by a Kinase Other Than Protein Kinase C After Exposure to Agonist (*)

Several guanine nucleotide-binding protein-coupled receptors are known to be rapidly phosphorylated after agonist exposure. In this study we show that the gastrin-releasing peptide receptor (GRP-R) is rapidly phosphorylated in response to agonist exposure. When [P]orthophosphate-labeled cells were exposed to bombesin, the receptor was maximally phosphorylated on serine and threonine residues within 1 min. Although addition of 12-O-tetradecanoylphorbol 13-acetate also resulted in phosphorylation of the GRP-R, elimination of protein kinase C activity using the inhibitor 7-hydroxystaurosporine did not prevent bombesin-induced GRP-R phosphorylation. We conclude that a kinase other than protein kinase C is principally responsible for the rapid, agonist-induced phosphorylation of the GRP-R.
Content Selection through Paraphrase Detection: Capturing different Semantic Realisations of the Same Idea

ive summarisation is one of the most challenging issues to address automatically, since it both requires deep language understanding and generation with a strong semantic component. For tackling this task, approaches usually need to define an internal representation of the text, that can be in the form of SVO triples (Genest and Lapalme, 2011), basic semantic units consisting of actor-action-receiver (Li, 2015), or using predarg structures (Khan et al., 2015). In this latter work, pred-arg structures extracted from different related documents are compared, so that common or redundant information can be grouped into clusters. For computing a similarity matrix, Wordnet1based similarity metrics are used, mainly relying on the semantic distance between concepts, given Wordnets’ hierarchy. On the other hand, previous works on linguistic structure mapping can be related to paraphrase identification (Fernando and Stevenson, 2008; Xu et al., 2015), as well as to pred-arg alignment (Wolfe et al., 2015; Roth and Frank, 2015). However, these works only use semantic similarity metrics based on WordNet or other semantic resources, such as ConceptNet2 or FrameNet3. https://wordnet.princeton. edu/ http://conceptnet5.media. mit.edu/ https://framenet.icsi. berkeley.edu/fndrupal/
Complete and partial XYLT1 deletion in a patient with neonatal short limb skeletal dysplasia

We report on a boy with a neonatal short limb skeletal dysplasia with serious medical complications, associated with one intragenic and one complete deletion of XYLT1. XYLT1 mutations have recently been reported as causative in recessive Desbuquois skeletal dysplasia (DBSD), but the skeletal features in our patient do not fit this diagnosis. It is possible that the phenotype of XYLT1 mutations extends to more aspecific types of short limb skeletal dysplasias and not to DBSD alone. © 2015 Wiley Periodicals, Inc.
Motion recognition by combining HMM and reinforcement learning

It is difficult to give a robot all possible motions beforehand in a certain environment. Therefore, the robot needs to learn how to recognize other motions and to generate its own motions autonomously for working well. These learning algorithms need an efficient way to make recognition and generation of motions work together, because they take many computing resources. This paper focuses on a generation-based recognition. Our system consists of recognition and generation modules. The fanner and latter are constructed from left-to-right hidden Markov models (HMM) and reinforcement learning (RL), respectively. When a HMM in recognition module does not work enough, the model parameters of HMM are re-estimated by using a state-value function of RL in generation module. The proposed method enables us to improve the reliability of the HMM.