Miracle-dz/UniFAR-FTUs huggingface dataset:
Symptoms and coping in Sri Lanka 20–21 months after the 2004 tsunami

Background The estimated prevalence of clinically significant psychiatric and somatic symptoms in adults >1 year after the 2004 Asian tsunami is unknown. Aims To estimate the prevalence of psychiatric and somatic symptoms and impairment in Sri Lanka 20–21 months after the 2004 Asian tsunami, and to assess coping strategies used by tsunami-affected individuals that contribute to post-tsunami adjustment. Method Homes from one severely affected area were randomly selected, and adult respondents were sampled utilising a modified Kish method. Instruments were administered in Sinhala to assess exposure, post-traumatic stress disorder (PTSD), depression, anxiety, somatic distress and impairment. Demographic variables and culturally-relevant coping activities were assessed. Results The prevalence of clinically significant PTSD, depression and anxiety was 21%, 16% and 30% respectively. Respondents reported a mean of eight persistent and bothersome somatic complaints, which were associated with psychiatric symptoms and impairment. Thinking that one's life was in danger was the exposure item most strongly associated with symptoms and impairment. The majority of respondents found their own strength, family and friends, a Western-style hospital and their religious practice to be the most helpful coping aids. Conclusions A large minority of adults in one area of Sri Lanka reported significant psychiatric and somatic symptoms and impairment 20–21 months after the tsunami. Accurate data about risk for and resilience to impairing symptoms > 1 year after disasters are necessary in order to develop rational surveillance and interventions.
The Inclusion-Exclusion Rule and its Application to the Junction Tree Algorithm

In this paper, we consider the inclusion-exclusion rule - a known yet seldom used rule of probabilistic inference. Unlike the widely used sum rule which requires easy access to all joint probability values, the inclusion-exclusion rule requires easy access to several marginal probability values. We therefore develop a new representation of the joint distribution that is amenable to the inclusion-exclusion rule. We compare the relative strengths and weaknesses of the inclusion-exclusion rule with the sum rule and develop a hybrid rule called the inclusion-exclusion-sum (IES) rule, which combines their power. We apply the IES rule to junction trees, treating the latter as a target for knowledge compilation and show that in many cases it greatly reduces the time required to answer queries. Our experiments demonstrate the power of our approach. In particular, at query time, on several networks, our new scheme was an order of magnitude faster than the junction tree algorithm.
Stable gauged maps

We give an introduction to moduli stacks of gauged maps satisfying a stability conditition introduced by Mundet and Schmitt, and the associated integrals giving rise to gauged Gromov-Witten invariants. We survey various applications to cohomological and K-theoretic Gromov-Witten invariants.
Lack of influence of the androgen receptor gene CAG‐repeat polymorphism on sex steroid status and bone metabolism in elderly men

OBJECTIVE Population means for serum testosterone (T) levels in healthy men decrease with ageing but there is considerable interindividual variability of serum T in elderly men. Ultimate androgen action is mediated through the androgen receptor. Subtle differences in androgen sensitivity might contribute to serum T variability through the T negative feedback regulation. The androgen receptor gene (AR) contains in exon 1 a polymorphic trinucleotide CAG‐repeat, whose length modulates androgen receptor action. The aims of the study were to assess the potential contribution of the AR CAG‐repeat polymorphism in the interindividual variability of serum T and in the determination of bone metabolism in ambulatory elderly men.
Validation of geolocation estimates based on light level and sea surface temperature from electronic tags

Electronic tags have enhanced our understanding of the movements and behavior of pelagic animals by providing position information from the Argos system satellites or by geolocation estimates using light levels and/or sea surface temperatures (SSTs). The ability to geolocate animals that remain submerged is of great value to fisheries management, but the accuracy of these geoloca- tion estimates has to be validated on free-swimming animals. In this paper, we report double-tagging experiments on free-swimming salmon sharks Lamna ditropis and blue sharks Prionace glauca, tagged with satellite telemetry and pop-up satellite tags, which provide a direct comparison between Argos positions and geolocation estimates derived from light levels and SSTs. In addition, the Argos- based pop-up satellite tag endpoints and GPS-based recapture locations of Atlantic bluefin tunas Thunnus thynnus were compared with the last geolocation estimates from pop-up satellite and archival tags. In the double-tagging experiments, the root mean square errors of the light level lon- gitude estimates were 0.89 and 0.55°; while for SST latitude estimates, the root mean square errors were 1.47 and 1.16° for salmon sharks and blue sharks respectively. Geolocation estimates of Atlantic bluefin tuna, using archival data from surgically implanted archival tags or recovered pop-up satel- lite tags, had root mean square errors of 0.78 and 0.90° for light level longitude and SST latitude esti- mates, respectively. Using data transmitted by pop-up satellite tags deployed on Atlantic bluefin tunas, the light level longitude and SST latitude estimates had root mean square errors of 1.30 and 1.89°, respectively. In addition, a series of computer simulations were performed to examine which variables were most likely to influence the accuracy of SST latitude estimates. The simulations indi- cated that the difference between the SST measured by the electronic tag and the remotely sensed SST at a given location was the predominant influence on the accuracy of SST latitude estimates. These results demonstrate that tag-measured SSTs can be used in conjunction with light level data to significantly improve the geolocation estimates from electronic tags.
Effect of Suberoylanilide Hydroxamic Acid (SAHA) Administration on the Residual Virus Pool in a Model of Combination Antiretroviral Therapy-Mediated Suppression in SIVmac239-Infected Indian Rhesus Macaques

ABSTRACT Nonhuman primate models are needed for evaluations of proposed strategies targeting residual virus that persists in HIV-1-infected individuals receiving suppressive combination antiretroviral therapy (cART). However, relevant nonhuman primate (NHP) models of cART-mediated suppression have proven challenging to develop. We used a novel three-class, six-drug cART regimen to achieve durable 4.0- to 5.5-log reductions in plasma viremia levels and declines in cell-associated viral RNA and DNA in blood and tissues of simian immunodeficiency virus SIVmac239-infected Indian-origin rhesus macaques, then evaluated the impact of treatment with the histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA; Vorinostat) on the residual virus pool. Ex vivo SAHA treatment of CD4+ T cells obtained from cART-suppressed animals increased histone acetylation and viral RNA levels in culture supernatants. cART-suppressed animals each received 84 total doses of oral SAHA. We observed SAHA dose-dependent increases in acetylated histones with evidence for sustained modulation as well as refractoriness following prolonged administration. In vivo virologic activity was demonstrated based on the ratio of viral RNA to viral DNA in peripheral blood mononuclear cells, a presumptive measure of viral transcription, which significantly increased in SAHA-treated animals. However, residual virus was readily detected at the end of treatment, suggesting that SAHA alone may be insufficient for viral eradication in the setting of suppressive cART. The effects observed were similar to emerging data for repeat-dose SAHA treatment of HIV-infected individuals on cART, demonstrating the feasibility, utility, and relevance of NHP models of cART-mediated suppression for in vivo assessments of AIDS virus functional cure/eradication approaches.
What is environmental stress? Insights from fish living in a variable environment

Although the term environmental stress is used across multiple fields in biology, the inherent ambiguity associated with its definition has caused confusion when attempting to understand organismal responses to environmental change. Here I provide a brief summary of existing definitions of the term stress, and the related concepts of homeostasis and allostasis, and attempt to unify them to develop a general framework for understanding how organisms respond to environmental stressors. I suggest that viewing stressors as environmental changes that cause reductions in performance or fitness provides the broadest and most useful conception of the phenomenon of stress. I examine this framework in the context of animals that have evolved in highly variable environments, using the Atlantic killifish, Fundulus heteroclitus, as a case study. Consistent with the extreme environmental variation that they experience in their salt marsh habitats, killifish have substantial capacity for both short-term resistance and long-term plasticity in the face of changing temperature, salinity and oxygenation. There is inter-population variation in the sensitivity of killifish to environmental stressors, and in their ability to acclimate, suggesting that local adaptation can shape the stress response even in organisms that are broadly tolerant and highly plastic. Whole-organism differences between populations in stressor sensitivity and phenotypic plasticity are reflected at the biochemical and molecular levels in killifish, emphasizing the integrative nature of the response to environmental stressors. Examination of this empirical example highlights the utility of using an evolutionary perspective on stressors, stress and stress responses.
Social Reflections on Fitness Tracking Data: A Study with Families in Low-SES Neighborhoods

Wearable activity trackers can encourage physical activity (PA)-a behavior critical for preventing obesity and reducing the risks of chronic diseases. However, prior work has rarely explored how these tools can leverage family support or help people think about strategies for being active-wo factors necessary for achieving regular PA. In this 2-month qualitative study, we investigated PA tracking practices amongst 14 families living in low-income neighborhoods, where obesity is prevalent. We characterize how social discussions of PA data rarely extended beyond the early stages of experiential learning, thus limiting the utility of PA trackers. Caregivers and children rarely analyzed their experiences to derive insights about the meaning of their PA data for their wellbeing. Those who engaged in these higher-order learning processes were often influenced by parenting beliefs shaped by personal health experiences. We contribute recommendations for how technology can more effectively support family experiential learning using PA tracking data.
Lack of motor prediction, rather than perceptual conflict, evokes an odd sensation upon stepping onto a stopped escalator

When stepping onto a stopped escalator, we often perceive an “odd sensation” that is never felt when stepping onto stairs. The sight of an escalator provides a strong contextual cue that, in expectation of the backward acceleration when stepping on, triggers an anticipatory forward postural adjustment driven by a habitual and implicit motor process. Here we contrast two theories about why this postural change leads to an odd sensation. The first theory links the odd sensation to a lack of sensorimotor prediction from all low-level implicit motor processes. The second theory links the odd sensation to the high-level conflict between the conscious awareness that the escalator is stopped and the implicit perception that evokes an endogenous motor program specific to a moving escalator. We show very similar postural changes can also arise from reflexive responses to visual stimuli, such as contracting/expanding optic flow fields, and that these reflexive responses produce similar odd sensations to the stopped escalator. We conclude that the high-level conflict is not necessary for such sensations. In contrast, the implicitly driven behavioral change itself essentially leads to the odd sensation in motor perception since the unintentional change may be less attributable to self-generated action because of a lack of motor predictions.
Extreme events and climate change: the post-disaster dynamics of forest fires and forest storms in Sweden

ABSTRACT How are extreme events understood in the forest sector? What are the implications of forest professionals' understandings and evaluations of extreme events? These questions are central to this study, which analyses the handling of the largest forest storm and the largest forest fire in modern Swedish history. The theoretical approach is that of risk governance in practice, which stresses that understanding the framings, practices and strategies used by members of professional organizations is pivotal for how disasters are managed. Two interview studies have been conducted with forest professionals involved in the two cases. The analysis shows that there were fundamentally different understandings of the two events and their implications for forestry practice. The storm was seen as an unavoidable natural disaster, but the consequences of future storms were considered possible to mitigate through changed forest practices. The forest fire, on the other hand, was conceptualized as a partly natural and partly man-made disaster, and forestry was seen as having very limited possibilities to reduce the likelihood as well as the consequences of similar events. The different understandings had significant implications for the post-disaster dynamics and for which management practices that were developed. Thus, understanding how extreme events are perceived is crucial to understanding which management practices that emerge in their wake, a topic of growing relevance because climate change is predicted to increase the frequency of forest fires and storms.
Activation of the anti‐inflammatory reflex blocks lipopolysaccharide‐induced decrease in synaptic inhibition in the temporal cortex of the rat

Stress is a potential trigger for a number of neuropsychiatric conditions, including anxiety syndromes and schizophrenic psychoses. The temporal neocortex is a stress‐sensitive area involved in the development of such conditions. We have recently shown that aseptic inflammation and mild electric shock shift the balance between synaptic excitation and synaptic inhibition in favor of the former in this brain area (Garcia‐Oscos et al., 2012), as well as in the prefrontal cortex (Garcia‐Oscos et al., 2014). Given the potential clinical importance of this phenomenon in the etiology of hyperexcitable neuropsychiatric illness, this study investigates whether inactivation of the peripheral immune system by the “anti‐inflammatory reflex” would reduce the central response to aseptic inflammation. For a model of aseptic inflammation, this study used i.p. injections of the bacterial toxin lipopolysaccharide (LPS; 5 µM) and activated the anti‐inflammatory reflex either pharmacologically by i.p. injections of the nicotinic α7 receptor agonist PHA543613 or physiologically through electrical stimulation of the left vagal nerve (VNS). Patch‐clamp recording was used to monitor synaptic function. Recordings from LPS‐injected Sprague Dawley rats show that activation of the anti‐inflammatory reflex either pharmacologically or by VNS blocks or greatly reduces the LPS‐induced decrease of the synaptic inhibitory‐to‐excitatory ratio and the saturation level of inhibitory current input–output curves. Given the ample variety of pharmacologically available α7 nicotinic receptor agonists as well as the relative safety of clinical VNS already approved by the FDA for the treatment of epilepsy and depression, our findings suggest a new therapeutic avenue in the treatment of stress‐induced hyperexcitable conditions mediated by a decrease in synaptic inhibition in the temporal cortex. © 2015 Wiley Periodicals, Inc.
Maize Inbreds Exhibit High Levels of Copy Number Variation (CNV) and Presence/Absence Variation (PAV) in Genome Content

Following the domestication of maize over the past ∼10,000 years, breeders have exploited the extensive genetic diversity of this species to mold its phenotype to meet human needs. The extent of structural variation, including copy number variation (CNV) and presence/absence variation (PAV), which are thought to contribute to the extraordinary phenotypic diversity and plasticity of this important crop, have not been elucidated. Whole-genome, array-based, comparative genomic hybridization (CGH) revealed a level of structural diversity between the inbred lines B73 and Mo17 that is unprecedented among higher eukaryotes. A detailed analysis of altered segments of DNA conservatively estimates that there are several hundred CNV sequences among the two genotypes, as well as several thousand PAV sequences that are present in B73 but not Mo17. Haplotype-specific PAVs contain hundreds of single-copy, expressed genes that may contribute to heterosis and to the extraordinary phenotypic diversity of this important crop.
Physical condition and stress levels during early development reflect feeding rates and predict pre- and post-fledging survival in a nearshore seabird

Snapshot nestling health measures can reveal reproductive effects of environmental stress while minimizing handling, disturbance and researcher effort. We tested two short-term measurements, body condition and feather corticosterone, as predictors of brown pelican nestling survival. Both measurements predicted nestling survival to fledge, and feather corticosterone also predicted post-fledging survival.
3,4,5-Tri-O-Caffeoylquinic Acid Promoted Hair Pigmentation Through β-Catenin and Its Target Genes

The hair follicle undergoes a regular cycle composed of three phases: anagen, catagen, and telogen. The life of follicular melanocytes is totally linked to the hair cycle; and during anagen or the growth phase, the melanocytes are active and produce the melanin responsible of hair shaft pigmentation. Various signaling pathways regulate the hair growth cycle and, therefore, the pigmentation; we distinguish the Wnt/β-catenin signaling pathway as it plays a major role in the development, growth, and proliferation of the melanocytes and the activation of melanogenesis enzymes and the related transcription factor. In this study, 3,4,5-tri-O-caffeoylquinic acid (TCQA), a caffeoylquinic acid derivative, stimulated the pigmentation in C3H mouse hair follicle, in human melanocytes, and B16F10 melanoma cells. An enhancement in pigmentation associated genes was observed upon TCQA treatment in vivo and in vitro. Interestingly, the expression of β-catenin was remarkably upregulated in mouse treated skin and in pigment cell lines. Moreover, TCQA upregulated CTNNB1 expression after inhibition in human melanocytes. Taken together, this study suggests that TCQA triggered β-catenin activation to enhance the pigmentation during the anagen phase of the hair cycle.
Fostering Competence: Lessons from Research on Successful Children.

Noting that even one caring adult can help make a child more capable of handling later stressors, this paper lists some strategies for building a sense of specialness in young children in group care contexts. Also presented are ways to enhance optimism and combat attitudes of helplessness and pessimism among children. The paper outlines a pattern of effective adaptation in the environment that includes four points: cognitive and intellectual functioning, attachment relationships, self-efficacy, and self-regulation. The paper lists the best and worst caregiving modes for competence-building, and infancy/preschool developmental tasks associated with competence. The characteristics of resilient children are grouped by individual, family, and extrafamilial traits. Finally, the paper discusses the importance of establishing a good start in early development for competence-building. (Contains 16 references.) (JPB) ******************************************************************************** * Reproductions supplied by EDRS are the best that can be made * * from the original document. * ********************************************************************************
Single molecule measurements of mechanical interactions within ternary SNARE complexes and dynamics of their disassembly: SNAP25 vs. SNAP23

Regulated exocytosis is a crucial event for intercellular communication between neurons and astrocytes within the CNS. The soluble N‐ethylmaleimide‐sensitive fusion protein attachment protein receptor (SNARE) complex, composed of synaptobrevin 2, syntaxin and synaptosome‐associated protein of 25 kDa or 23 kDa (SNAP25 or SNAP23), is essential in this process. It was reported that SNAP25 and SNAP23 have distinct roles in exocytotic release, where SNAP25, but not SNAP23, supports an exocytotic burst. It is not clear, however, whether this is due to the intrinsic properties of the ternary SNARE complex, containing either SNAP25 or SNAP23, or perhaps due to the differential association of these proteins with ancillary proteins to the complex. Here, using force spectroscopy, we show from single molecule investigations of the SNARE complex, that SNAP23A created a local interaction at the ionic layer by cuffing syntaxin 1A and synaptobrevin 2, similar to the action of SNAP25B; thus either of the ternary complexes would allow positioning of vesicles at a maximal distance of ∼13 nm from the plasma membrane. However, the stability of the ternary SNARE complex containing SNAP23A is less than half of that for the complex containing SNAP25B. Thus, differences in the stability of the two different ternary complexes could underlie some of the SNAP25/23 differential ability to control the exocytotic burst.
The Strategic Impact of Higher-Order Beliefs

Previous research has established that the predictions made by game theory about strategic behavior in incomplete information games are quite sensitive to the assumptions made about the players' infinite hierarchies of beliefs. We evaluate the severity of this robustness problem by characterizing conditions on the primitives of the model -- the players’ hierarchies of beliefs -- for the strategic behavior of a given Harsanyi type to be approximated by the strategic behavior of (a sequence of) perturbed types. This amounts to providing characterizations of the strategic topologies of Dekel, Fudenberg, and Morris (2006) in terms of beliefs. We apply our characterizations to a variety of questions concerning robustness to perturbations of higher-order beliefs, including genericity of common priors, and the connections between robustness of strategic behavior and the notion of common p-belief of Monderer and Samet (1989).