Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification of the second gonadotropin-releasing hormone in chicken hypothalamus: evidence that gonadotropin secretion is probably controlled by two distinct gonadotropin-releasing hormones in avian species.

A new peptide having gonadotropin-releasing activity distinct from the known luteinizing hormone-releasing hormones ( LHRHs ) has been identified in a chicken hypothalamic extract. The existence of [Gln8]LHRH in avian hypothalamus has been reported previously. The new molecular species of gonadotropin-releasing activity, named chicken gonadotropin-releasing hormone II (chicken GnRH-II), has been isolated recently in a yield of 7 micrograms, starting from 10,000 chicken hypothalami. Structural analyses have been performed on the peptide fragments derived from chymotryptic and thermolytic digests of chicken GnRH-II by amino acid analyses and terminal analyses. The full sequence of chicken GnRH-II has been determined to be: pGlu-His-Trp-Ser-His-Gly-Trp-Tyr-Pro-Gly-NH2. A synthetic decapeptide with the above sequence was verified to be chromatographically identical to natural chicken GnRH-II. For further structural confirmation, chymotryptic and thermolytic peptides from synthetic and natural chicken GnRH-II also were identified. Thus, the structure of chicken GnRH-II has been definitely established. The gonadotropin-releasing potency of chicken GnRH-II was about 32% of that of mammalian LHRH and 8 times more potent than chicken LHRH, as estimated from the bioassay with rat anterior pituitary cells. Our results indicate that gonadotropin secretion is probably controlled by two distinct GnRHs , at least in avian species.
A General Modeling Strategy for Gene Regulatory Networks with Stochastic Dynamics

A stochastic genetic toggle switch model that consists of two identical, mutually repressive genes is built using the Gillespie algorithm with time delays as an example of a simple stochastic gene regulatory network. The stochastic kinetics of this model is investigated, and it is found that the delays for the protein productions can highly weaken the global fluctuations for the expressions of the two genes, making the two mutually repressive genes coexist for a long time. Starting from this model, we propose a practical modeling strategy for more complex gene regulatory networks. Unlike previous applications of the Gillespie algorithm to simulate specific genetic networks dynamics, this modeling strategy is proposed for an ensemble approach to study the dynamical properties of these networks. The model allows any combination of gene expression products, forming complex multimers, and each one of the multimers is assigned to a randomly chosen gene promoter site as an activator or inhibitor. In addition, each gene, although it has only one promoter site, can have multiple regulatory sites and distinct rates of translation and transcription. Also, different genes have different time delays for transcription and translation and all reaction constant rates are initially randomly chosen from a range of values. Therefore, the general strategy here proposed may be used to simulate real genetic networks.
Improved implementation of a modified Discrete Cosine Transform on low-cost FPGA

In this paper, Discrete Cosine Transform hardware implementations are performed using two different modified Loeffler algorithms and are compared to the original one. The arithmetic modifications are presented and the correspondent algorithms are synthesized and implemented on a low-cost FPGA. The results show a significant increase of the maximum frequency operation with a new proposed modified Loeffler algorithm.
Structure, Expression, and Motion in Facial Attractiveness

This article reviews recent developments in experimental facial attractiveness research. It outlines the important social consequences of facial attractiveness in social life and briefly reviews the structural factors associated with attractiveness in both sexes taking a theoretical perspective largely influenced by evolutionary biology. The study discusses individual differences in preferences from this theoretical perspective. Attractiveness is also affected by aspects of the face that are manifestly not static. Facial motion and expression involve changing configurations of the face and the execution of specific, discrete gestures that are likely to contribute to attractiveness and yet are largely neglected in the current literature. It shows how an evolutionary viewpoint is also useful when considering attractiveness judgments when expressive or dynamic cues are present in stimuli.
Instrumentos de gobernanza en la universidad: dinamizadores del sistema de innovación regional

espanolEste trabajo describe diversos instrumentos de gobernanza en las universidades, que potencian su papel como agentes dinamizadores del Sistema Andaluz del Conocimiento (I+D+i). Para ello, tras una introduccion, se definen los sistemas de innovacion y se destaca la importancia de ciertas dimensiones del sistema de gobernanza de las instituciones de educacion superior; seguidamente, se describen las politicas implantadas para potenciar el papel de las universidades en la innovacion regional; finalmente, se ofrecen resultados de un grupo de indicadores y de un analisis DAFO, que permiten medir los avances que estan logrando en el citado sistema EnglishThis paper describes tools of university governance that can strengthen the role of universities as a driving force for the Andalusian Knowledge System (RD next, we explain some policies implemented to enhance the role of universities in regional innovation; finally, the paper shows results from a group of indicators and a SWOT analysis that allow to measure the progress produced in the mentioned Systems.
The Five-Factor Model of Personality in Borderline and Nonborderline Personality Disorders

Objective The purpose of this study was to examine to what extent the phenomena associated with a diagnosis of borderline personality disorder (BPD) can be described by the five-factor model of personality. Method The sample consisted of female patients with BPD (n=29) and a control group with a mixture of nonborderline personality disorders (n=30). All subjects were given the NEO-PI-R. Results Borderline patients differed from community norms on all five factors, and were particularly high on Neuroticism, and particularly low on Agreeableness. The scores on the five factors did not differ significantly between the 2 clinical groups. Two facets of the conscientiousness scale (competence and deliberation) were significantly lower in the BPD group. Conclusions Dimensional profiles only partially account for the clinical symptomatology seen in formally diagnosed cases of BPD.
Operationalizing Central Place Theory and Central Flow Theory with mobile phone data

Central Place and Central Flow Theory are geographic principles explaining why and how cities develop across large regional spaces. Central Place Theory postulates that cities self-organize into a spatial hierarchy were small numbers of very large ‘Central Places’ support numerous surrounding and less developed ‘Low Places’, while ‘Middle Places’ develop at the periphery of where Central Places carry spatial influence. Central Flow Theory is a complementary notion that explains the cooperative development of cities through joint information sharing. Both theories are often discussed, with multiple regional development and economic models built upon their tenents. However, it is very difficult to quantify the degree to which Central Place and Central Flow Theory explains the development and positions of cities in a region, particularly in developing countries where socioeconomic data is difficult to collect. To facilitate these measurements, this paper presents a way to operationalize Central Place and Central Flow Theory using mobile phone data collected across a region. It defines a set of mobile phone data attributes that are related to basic facets of the two theories, and demonstrates how their measurements speak to the degree to which the theories hold in the region the mobile phone data covers. The theory is then applied in a case study where promising locations for economic investment in a developing nation are identified.
Probabilistic kernel least mean squares algorithms

The kernel least mean squares (KLMS) algorithm is a computationally efficient nonlinear adaptive filtering method that “kernelizes” the celebrated (linear) least mean squares algorithm. We demonstrate that the least mean squares algorithm is closely related to the Kalman filtering, and thus, the KLMS can be interpreted as an approximate Bayesian filtering method. This allows us to systematically develop extensions of the KLMS by modifying the underlying state-space and observation models. The resulting extensions introduce many desirable properties such as “forgetting”, and the ability to learn from discrete data, while retaining the computational simplicity and time complexity of the original algorithm.
Comparing Clonidine and Lidocaine on Attenuation of Hemodynamic Responses to Laryngoscopy and Tracheal Intubation in Controlled Hypertensive Patients: A Randomized, Double-Blinded Clinical Trial

Background: Hemodynamic fluctuations in response to laryngoscopy and tracheal intubation and their potential hazards have been well-recognized, especially in hypertensive patients. Many drugs in various combinations have been used to attenuate these adverse responses. Objectives: We conducted a study to compare lidocaine with clonidine on the attenuation of hemodynamic responses to laryngoscopy and tracheal intubation, in controlled hypertensive patients undergoing general anesthesia. Patients and Methods: Eighty-six patients of American society of anesthesiologists (ASA) class II, who were aged 18 to 65-years-old and were scheduled for elective surgeries under general anesthesia, were included. The patients were randomly divided into two equal groups. The clonidine group received 0.2 mg oral clonidine 90 minutes before surgery and the lidocaine group received a placebo tablet at the same time. All patients in both groups were anesthetized with the same technique, including: intravenous fentanyl 3 mcg/kg, sodium thiopental 5 mg/kg, and atracurium 0.5 mg/kg. The lidocaine group received 1.5 mg/kg lidocaine but the clonidine group received the same volume of saline ninety seconds before intubation. Hemodynamic parameters were recorded before intubation and 1, 3, 5, and 10 minutes after endotracheal intubation. Results: There were no significant differences between the two groups’ hemodynamic parameters, including heart rate and systolic, diastolic, and mean arterial blood pressures at the measured points. There were also no significant differences within each group in hemodynamic responses at the measured points (P > 0.05). Twenty patients in the clonidine and three patients in the lidocaine group complained of mouth dryness (P = 0.001). Fourteen patients in the clonidine and four patients in the lidocaine group had bradycardia (P = 0.008). Nineteen patients in the clonidine and six patients in the lidocaine group had orthostatic hypotension (P = 0.002). Conclusions: There were no statistical differences between oral clonidine and intravenous lidocaine regarding attenuation of hemodynamic responses after tracheal intubation in controlled hypertensive patients, although the rate of complications including mouth dryness, bradycardia, and orthostatic hypotension was significantly higher in the clonidine group before induction of anesthesia.
Everolimus plus exemestane for hormone-receptor-positive, human epidermal growth factor receptor-2-negative advanced breast cancer: overall survival results from BOLERO-2†.

BACKGROUND The BOLERO-2 study previously demonstrated that adding everolimus (EVE) to exemestane (EXE) significantly improved progression-free survival (PFS) by more than twofold in patients with hormone-receptor-positive (HR(+)), HER2-negative advanced breast cancer that recurred or progressed during/after treatment with nonsteroidal aromatase inhibitors (NSAIs). The overall survival (OS) analysis is presented here. PATIENTS AND METHODS BOLERO-2 is a phase III, double-blind, randomized international trial comparing EVE 10 mg/day plus EXE 25 mg/day versus placebo (PBO) + EXE 25 mg/day in postmenopausal women with HR(+) advanced breast cancer with prior exposure to NSAIs. The primary end point was PFS by local investigator assessment; OS was a key secondary end point. RESULTS At the time of data cutoff (3 October 2013), 410 deaths had occurred and 13 patients remained on treatment. Median OS in patients receiving EVE + EXE was 31.0 months [95% confidence interval (CI) 28.0-34.6 months] compared with 26.6 months (95% CI 22.6-33.1 months) in patients receiving PBO + EXE (hazard ratio = 0.89; 95% CI 0.73-1.10; log-rank P = 0.14). Poststudy treatments were received by 84% of patients in the EVE + EXE arm versus 90% of patients in the PBO + EXE arm. Types of poststudy therapies were balanced across arms, except for chemotherapy (53% EVE + EXE versus 63% PBO + EXE). No new safety concerns were identified. CONCLUSIONS In BOLERO-2, adding EVE to EXE did not confer a statistically significant improvement in the secondary end point OS despite producing a clinically meaningful and statistically significant improvement in the primary end point, PFS (4.6-months prolongation in median PFS; P < 0.0001). Ongoing translational research should further refine the benefit of mTOR inhibition and related pathways in this treatment setting. TRIAL REGISTRATION NUMBER NCT00863655.
Goal-oriented requirement analysis for data warehouse design

Several surveys indicate that a significant percentage of data warehouses fail to meet business objectives or are outright failures. One of the reasons for this is that requirement analysis is typically overlooked in real projects. In this paper we propose a goal-oriented approach to requirement analysis for data warehouses, based on the Tropos methodology. Two different perspectives are integrated for requirement analysis: organizational modeling, centered on stakeholders, and decisional modeling, focused on decision makers. Our approach can be employed within both a demand-driven and a mixed supply/demand-driven design framework: in the second case, while the operational sources are still explored to shape hierarchies, user requirements play a fundamental role in restricting the area of interest for analysis and in choosing facts, dimensions, and measures. The methodology proposed, supported by a prototype, is described with reference to a real case study.
The Mad and Myc Basic Domains Are Functionally Equivalent*

The Myc/Max/Mad family of transcription factors plays a fundamental role in the regulation of cell proliferation, oncogenic transformation, and cell differentiation. However, it remains unclear whether different heterodimers, such as Myc/Max and Mad/Max, recognize the same or different target genesin vivo. We show by chromatin immunoprecipitation that Myc target genes are also recognized by Mad1 in differentiated HL60 cells. We also substituted the complete basic region of Myc for the corresponding region of Mad. Wild-type c-Myc was then compared with c-Myc(Mad-BR) in oncogenic transformation, regulation of cell proliferation, induction of apoptosis, activation of chromosomal gene expression, and direct binding to chromosomal sites by chromatin immunoprecipitation. We find that the wild-type c-Myc and c-Myc/MadBR proteins have indistinguishable biological activity and target gene recognition in vivo. These data are consistent with a model in which Myc and Mad regulate a common set of target genes.
Detection of Natural Resistance-Associated Substitutions by Ion Semiconductor Technology in HCV1b Positive, Direct-Acting Antiviral Agents-Naïve Patients

Naturally occurring resistance-associated substitutions (RASs) can negatively impact the response to direct-acting antivirals (DAAs) agents-based therapies for hepatitis C virus (HCV) infection. Herein, we set out to characterize the RASs in the HCV1b genome from serum samples of DAA-naïve patients in the context of the SINERGIE (South Italian Network for Rational Guidelines and International Epidemiology, 2014) project. We deep-sequenced the NS3/4A protease region of the viral population using the Ion Torrent Personal Genome Machine, and patient-specific majority rule consensus sequence summaries were constructed with a combination of freely available next generation sequencing data analysis software. We detected NS3/4A protease major and minor variants associated with resistance to boceprevir (V36L), telaprevir (V36L, I132V), simeprevir (V36L), and grazoprevir (V36L, V170I). Furthermore, we sequenced part of HCV NS5B polymerase using Sanger-sequencing and detected a natural RAS for dasabuvir (C316N). This mutation could be important for treatment strategies in cases of previous therapy failure.
Retinal pigment epithelial tears following ranibizumab therapy for fibrovascular retinal pigment epithelial detachment due to occult age-related macular degeneration

Summary Background The aim of this paper is to report the incidence of retinal pigment epithelial (RPE) tears in patients treated with ranibizumab for subfoveal fibrovascular retinal pigment epithelial detachment (FVPED) due to occult age-related macular degeneration (AMD). Material/Methods Thirty patients were treated according to the following schedule: saturation phase, further treatment was based on activity of the degeneration process. Visual acuity (VA), optical coherence tomography (OCT) and fluorescein angiography (FA) parameters were evaluated and compared. Results Patients had a mean improvement of +4.7±8.1 letters at month 12. The mean number of needed injections was 6.8±1.8 (range, 3 to 9). RPE tears in fovea occurred in 8 cases (27% of all patients). Analysis of variance revealed significant upper mean values of ETDRS letters for the subgroup without RPE tears. Mean values of PED height were significant upper for RPE tears without baseline. Statistical analysis revealed that in the subgroup without RPE tears mean values of VA significantly differed in succeeding periods compare to baseline (P<0.001). Visual improvement or stabilization was observed in 90.9% of patients without RPE tears (significant improvement of 15 or more letters in 22.7%–5/22) and in 87.5% of patients with RPE tears (significant improvement was not observed). Baseline leakage parameters, lesion and leakage parameters at month 12 were significantly higher in patients with RPE tears. The chi-square test revealed statistically significant associations between RPE tears and subretinal fluid in OCT (P<0.05) at month 12. Conclusions In eyes with FVPED and RPE tears treated with ranibizumab, stabilization of visual acuity without significant improvement is predictable. One of the risk factors common to RPE tears may be baseline leakage parameters and pretreatment distorted RPE contour in OCT. During ranibizumab therapy in eyes with RPE tears, upper parameters of FVPED height may occur without significant differences in fovea and macula volume compare to eyes without RPE tears.
Path and speed control of a heavy vehicle for collision avoidance manoeuvres

In an emergency situation prior to an imminent accident, first in-vehicle warning systems would intervene and aim to make the driver to take a suitable action. If the risk of accident was not eliminated, then an autonomous collision avoidance manoeuvre can prevent it. In this work, path and speed control are intended to be used to perform such a manoeuvre by using steering and braking actuators respectively. In order to provide actuators with suitable control inputs, first a path is planned for the heavy vehicle to follow during the manoeuvre. Then the path is used to calculate feedforward control inputs whereas a feedback controller assures the path tracking by compensating for errors. As a result, a robust path planning and control algorithm is designed and implemented that can perform autonomous collision avoidance manoeuvres for a heavy vehicle. Promising simulation results support ongoing works on vehicle demonstration and experiments on a real heavy vehicle.
The neuropsychology of face perception: beyond simple dissociations and functional selectivity

Face processing relies on a distributed, patchy network of cortical regions in the temporal and frontal lobes that respond disproportionately to face stimuli, other cortical regions that are not even primarily visual (such as somatosensory cortex), and subcortical structures such as the amygdala. Higher-level face perception abilities, such as judging identity, emotion and trustworthiness, appear to rely on an intact face-processing network that includes the occipital face area (OFA), whereas lower-level face categorization abilities, such as discriminating faces from objects, can be achieved without OFA, perhaps via the direct connections to the fusiform face area (FFA) from several extrastriate cortical areas. Some lesion, transcranial magnetic stimulation (TMS) and functional magnetic resonance imaging (fMRI) findings argue against a strict feed-forward hierarchical model of face perception, in which the OFA is the principal and common source of input for other visual and non-visual cortical regions involved in face perception, including the FFA, face-selective superior temporal sulcus and somatosensory cortex. Instead, these findings point to a more interactive model in which higher-level face perception abilities depend on the interplay between several functionally and anatomically distinct neural regions. Furthermore, the nature of these interactions may depend on the particular demands of the task. We review the lesion and TMS literature on this topic and highlight the dynamic and distributed nature of face processing.
May Chlamydia trachomatis be an aetiological agent of chronic prostatic infection?

Chlamydia trachomatis infection is the most common sexually transmitted bacterial disease. The objective of this study was to establish the presence/absence of C. trachomatis in 98 patients with chronic complaints about the prostate and to evaluate the role of this bacterium in the inflammation of the gland. We performed culture and microscopical examination of pre‐massage/post‐massage urine and expressed prostatic secretions (EPS). In all cases, culture on McCoy cells and polymerase chain reaction (PCR) of the EPS was performed. Based on laboratory findings in 53 cases (54.08%), Escherichia coli, Klebsiella, Enterobacter, Proteus, Pseudomonas and Staphylococcus were isolated and accepted as causative agents of chronic bacterial prostatitis. Forty‐five patients were categorised as patients with chronic pelvic pain syndrome. The results from the PCR and the cell culture for detection of C. trachomatis were as follows – two positive probes detected at the same time by applying PCR and cultivation and 1 positive only by PCR but not by cultivation on the cell line. Based on these results, it is concluded that C. trachomatis is not so frequently detected in our patients. C. trachomatis may be accepted as one of the aetiological agents of chronic prostatitis and testing for this infection is highly recommended when presumption for chronic prostatitis is apparent.