Miracle-dz/UniFAR-FTUs huggingface dataset:
Induction Chemotherapy Followed by Concurrent Full-dose Gemcitabine and Intensity-modulated Radiation Therapy for Borderline Resectable and Locally Advanced Pancreatic Adenocarcinoma

Objective:To evaluate the outcomes and toxicity of concurrent full-dose gemcitabine and intensity-modulated radiation therapy (IMRT) for patients with borderline resectable and locally advanced pancreatic adenocarcinoma after induction chemotherapy. Materials and Methods:From 2009 to 2012, 32 patients were treated with concurrent gemcitabine and IMRT for borderline resectable or locally advanced pancreatic adenocarcinoma. All patients received induction FOLFIRINOX or gemcitabine-based chemotherapy before chemoradiation. The radiotherapy volume was limited to the primary tumor, and the median dose was 55 Gy in 25 fractions. Gemcitabine was administered weekly during radiotherapy on days 1, 8, 22, and 29 at a median weekly dose of 800 mg/m2. Results:Twenty-five patients had locally advanced disease and 7 had borderline resectable disease. The median follow-up time was 14.6 months. The median progression-free and overall survival were 13.9 and 23.1 months, with a trend toward improved overall survival for patients receiving induction FOLFIRINOX compared with gemcitabine-based therapy. A radiographic complete or partial response was achieved in 13 patients (41%), with 4 (13%) having complete radiographic responses. Surgical resection was performed in 10 patients (31%)—6 patients with locally advanced disease and 4 with borderline resectable disease. Grade 3/4 hematologic toxicity during and up to 6 weeks after chemoradiation occurred in 12 patients (38%); grade 3 nonhematologic toxicity occurred in 7 patients (22%), with no grade 4 or 5 toxicity. All patients completed their radiotherapy. Conclusions:Concurrent full-dose gemcitabine and limited-field IMRT after induction chemotherapy for the treatment of borderline resectable and locally advanced pancreatic cancer is promising with acceptable toxicity rates.
The Handbook of Mentalization-Based Treatment

About the Editors. List of Contributors. Foreword by Susan W. Coates. Preface by Jon G. Allen and Peter Fonagy. Part I: CONCEPTUAL AND CLINICAL FOUNDATIONS. 1 Mentalizing in Practice (Jon G. Allen). 2 Mentalizing from a Psychoanalytic Perspective: What's New? (Jeremy Holmes). Part II: DEVELOPMENTAL PSYCHOPATHOLOGY. 3 The Mentalization-Focused Approach to Social Development (Peter Fonagy). 4 Mentalizing Problems in Childhood Disorders (Carla Sharp). 5 A Neurobiological Perspective on Mentalizing and Internal Object Relations in Traumatized Patients with Borderline Personality Disorder (Glen O. Gabbard, Lisa A. Miller and Melissa Martinez). Part III: INCORPORATING MENTALIZING IN ESTABLISHED TREATMENTS. 6 Integrating Mentalization-Based Treatment and Traditional Psychotherapy to Cultivate Common Ground and Promote Agency (Richard L. Munich). 7 Cognitive Behavioral Therapy Promotes Mentalizing (Throstur Bjorgvinsson and John Hart). 8 Enhancing Mentalizing Capacity through Dialectical Behavior Therapy Skills Training and Positive Psychology (Lisa Lewis). Part IV: MENTALIZATION-BASED THERAPY. 9 Mentalizing and Borderline Personality Disorder (Anthony Bateman and Peter Fonagy). 10 Short-Term Mentalization and Relational Therapy (SMART): An Integrative Family Therapy for Children and Adolescents (Pasco Fearon, Mary Target, Peter Fonagy, Laurel L. Williams, Jacqueline McGregor, John Sargent and Efrain Bleiberg). 11 Training Psychiatry Residents in Mentalization-Based Therapy (Laurel L.Williams, Peter Fonagy, Mary Target, Pasco Fearon, John Sargent, Efrain Bleiberg and Jacqueline McGregor). 12. Treating Professionals in Crisis: A Mentalization-Based Specialized Inpatient Program (Efrain Bleiberg). 13. Enhancing Mentalizing through Psycho-Education (G. Tobias G. Haslam-Hopwood, Jon G. Allen, April Stein and Efrain Bleiberg). Part V: PREVENTION. 14. Minding the Baby: A Mentalization-Based Parenting Program (Lois S. Sadler, Arietta Slade and Linda C. Mayes). 15. Transforming Violent Social Systems into Non-Violent Mentalizing Systems: An Experiment in Schools (Stuart W. Twemlow and Peter Fonagy). 16. Does Mentalizing Promote Resilience? (Helen Stein). Epilogue (Robert Michels). Index.
Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates

The Cockayne syndrome B (CSB) protein—defective in a majority of patients suffering from the rare autosomal disorder CS—is a member of the SWI2/SNF2 family with roles in DNA repair and transcription. We demonstrate herein that purified recombinant CSB and the major human apurinic/apyrimidinic (AP) endonuclease, APE1, physically and functionally interact. CSB stimulates the AP site incision activity of APE1 on normal (i.e. fully paired) and bubble AP–DNA substrates, with the latter being more pronounced (up to 6-fold). This activation is ATP-independent, and specific for the human CSB and full-length APE1 protein, as no CSB-dependent stimulation was observed with Escherichia coli endonuclease IV or an N-terminal truncated APE1 fragment. CSB and APE1 were also found in a common protein complex in human cell extracts, and recombinant CSB, when added back to CSB-deficient whole cell extracts, resulted in increased total AP site incision capacity. Moreover, human fibroblasts defective in CSB were found to be hypersensitive to both methyl methanesulfonate (MMS) and 5-hydroxymethyl-2′-deoxyuridine, agents that introduce base excision repair (BER) DNA substrates/intermediates.
Caregiver self-efficacy, self-care, management of emotions, the amount of and satisfaction with help from others, and the use of community resources: An analysis of the powerful tools for caregivers program

In recent decades a literature has accumulated demonstrating caregivers experience higher rates of mental and physical health problems compared to non-caregivers (Baumgarten, Battista, Infante-Rivard, Hanley, Becker, & Gauthier, 1992; Shaw et al., 1997). Vitalinao, Zhang, and Scanlan (2003) found these health problems may be, in part, attributed to high stress levels, as their 23-study meta-analysis found caregivers had 23% higher stress hormone levels and 15% lower antibody response levels than non-caregivers. A number of psychoeducational interventions have been developed (e.g., Powerful Tools for Caregivers), to provide caregivers with a range of skills for better managing stress; however, few interventions have research supporting their effectiveness. Therefore, the current study sought to help fill the literature gap by, examining the effectiveness of the Powerful Tools for Caregivers (PTC) program. The purpose of the study was to: (a) examine the effect of the PTC intervention, on caregiver self-efficacy, self-care, emotional management, amount of and satisfaction with help from others, and use of community resources scores measured via pre-post score changes with the instrument developed and validated to assess the PTC program; (b) assess if caregivers’ responses to the intervention (pre-post PTC program outcome scores) differ by age, gender, or education; and (c) examine if care receivers’ memory loss, medical condition, or living situation are associated with significant differences in caregivers’ pre-post PTC program outcome scores following the intervention. Results demonstrated caregivers’ self-efficacy, self-care, emotion, help, and resource scores significantly improved following the PTC intervention compared to pre-class levels. Results also demonstrated, in a large majority of cases, caregivers not only improved their outcome scores, but also did so in a uniform fashion, regardless of their age, gender, or education
Alcohol Consumption and Risk of Stroke Among Middle-Aged Men: The JPHC Study Cohort I

Background and Purpose— The impact of light-to-moderate alcohol consumption on risk of stroke has not been well examined in a single study, although the effect is hypothesized to differ among stroke subtypes from meta-analyses. Methods— A total of 19 544 men aged 40 to 59 years living in communities were followed-up from 1990 to 1992 to the end of 2001 in the Japan Public Health Center-based Prospective Study on Cancer and Cardiovascular Disease (JPHC Study). Results— After 214 504 person-years of follow-up, 694 incident strokes were documented, of which 611 were confirmed by imaging studies or autopsy, including 219 intraparenchymal hemorrhages, 73 subarachnoid hemorrhages, and 319 ischemic strokes. Alcohol consumption was positively associated with age-adjusted risk of total stroke with a 68% excess risk among drinkers of ≥450 g ethanol per week compared with occasional drinkers. This excess risk was confined primarily to hemorrhagic stroke, which remained statistically significant even after controlling for hypertension and other cardiovascular risk factors (RR: 2.15; 95% CI: 1.22 to 3.79). There was a lower risk of ischemic stroke, more specifically lacunar infarction, a higher risk of hemorrhagic stroke, and no excess risk of total stroke among drinkers of 1 to 149 g ethanol per week compared with occasional drinkers; the respective multivariate RR (95% CI) was 0.59 (0.37 to 0.93), 0.43 (0.22 to 0.87), 1.73 (0.98 to 3.07), and 0.98 (0.71 to 1.36). Conclusions— We found differential effects of light-to-moderate alcohol consumption on risks of hemorrhagic and ischemic strokes among middle-aged men. Light-to-moderate alcohol consumption, ie, ≤2 drinks per day, does not raise the risk of total stroke.
The effects of Salsa dance on balance, gait, and fall risk in a sedentary patient with Alzheimer's dementia, multiple comorbidities, and recurrent falls.

BACKGROUND AND PURPOSE Recent studies have looked at the effects of dance on functional outcomes for persons with balance, gait, and cognitive impairments. The purpose of this report is to quantify the effects of Salsa dance therapy on function, balance, and fall risk in a sedentary older patient with multiple comorbidities. CASE DESCRIPTION/INTERVENTION: The patient was an 84-year-old woman with functional decline due to Alzheimer's dementia, late effects of a cerebral hemorrhagic aneurysm with right hemiparesis in the lower extremity, arthritis, and recurrent falls. Intervention consisted largely of Salsa dancing activities for 24 sessions over 12 weeks. OUTCOMES The patient showed improvements in range of motion, strength, balance, functional mobility, gait distance, and speed. During the course of therapy, 1 fall was reported with no significant injuries and 6 months postintervention the patient/caregiver reported no falls. DISCUSSION This case describes the clinically meaningful effects of Salsa dance therapy as a primary intervention and its impact on functional recovery in a geriatric patient with multiple impairments.
Gut-Brain Endocrine Axes in Weight Regulation and Obesity Pharmacotherapy

In recent years, the obesity epidemic has developed into a major health crisis both in the United States as well as throughout the developed world. With current treatments limited to expensive, high-risk surgery and minimally efficacious pharmacotherapy, new therapeutic options are urgently needed to combat this alarming trend. This review focuses on the endogenous gut-brain signaling axes that regulate appetite under physiological conditions, and discusses their clinical relevance by summarizing the clinical and preclinical studies that have investigated manipulation of these pathways to treat obesity.
Retrofitting existing chemical scrubbers to biotrickling filters for H2S emission control

Biological treatment is a promising alternative to conventional air-pollution control methods, but thus far biotreatment processes for odor control have always required much larger reactor volumes than chemical scrubbers. We converted an existing full-scale chemical scrubber to a biological trickling filter and showed that effective treatment of hydrogen sulfide (H2S) in the converted scrubber was possible even at gas contact times as low as 1.6 s. That is 8–20 times shorter than previous biotrickling filtration reports and comparable to usual contact times in chemical scrubbers. Significant removal of reduced sulfur compounds, ammonia, and volatile organic compounds present in traces in the air was also observed. Continuous operation for >8 months showed stable performance and robust behavior for H2S treatment, with pollutant-removal performance comparable to that achieved by using a chemical scrubber. Our study demonstrates that biotrickling filters can replace chemical scrubbers and be a safer, more economical technique for odor control.
Temporal Variations in the Hepatitis C Virus Intrahost Population during Chronic Infection

ABSTRACT The intrahost evolution of hepatitis C virus (HCV) holds keys to understanding mechanisms responsible for the establishment of chronic infections and to development of a vaccine and therapeutics. In this study, intrahost variants of two variable HCV genomic regions, HVR1 and NS5A, were sequenced from four treatment-naïve chronically infected patients who were followed up from the acute stage of infection for 9 to 18 years. Median-joining network analysis indicated that the majority of the HCV intrahost variants were observed only at certain time points, but some variants were detectable at more than one time point. In all patients, these variants were found organized into communities or subpopulations. We hypothesize that HCV intrahost evolution is defined by two processes: incremental changes within communities through random mutation and alternations between coexisting communities. The HCV population was observed to incrementally evolve within a single community during approximately the first 3 years of infection, followed by dispersion into several subpopulations. Two patients demonstrated this pattern of dispersion for the rest of the observation period, while HCV variants in the other two patients converged into another single subpopulation after ∼9 to 12 years of dispersion. The final subpopulation in these two patients was under purifying selection. Intrahost HCV evolution in all four patients was characterized by a consistent increase in negative selection over time, suggesting the increasing HCV adaptation to the host late in infection. The data suggest specific staging of HCV intrahost evolution.
Exploiting platform diversity for GoS improvement for users with different High Altitude Platform availability

This paper investigates the ways of improving the Grade-of-Service (GoS) in a coexistence scenario with different user types in a multiple High Altitude Platforms (HAPs) system with shared coverage area and radio spectrum. It is achieved through the exploitation of HAP diversity. An analytical model based on a two-dimensional state-transition-rate diagram is developed to describe system behaviour of a coexistence scenario containing two user groups, which have full and limited HAP availability. On the basis of the analytical model, a novel restriction mechanism is implemented in order to achieve a fair balance of GoS to the two user groups using connection admission control (CAC). The mechanism restricts access to the channel resource for users with full HAP choice in order to give more chance of access to users with a more limited HAP selection. Different types of restriction function are analysed and the paper shows that a step restriction function is the most suitable mechanism to provide a balanced low blocking probability performance to both user groups simultaneously. Furthermore, the mechanism can potentially provide a certain level of GoS guarantee for the users if adequate flexibility is available within the whole system.
Input pruning for neural gas architectures

The neural gas algorithm provides a methodto cluster a data space via an adaptive lattice of neurons which captures the topology of the data space. We propose di(cid:11)erent methods to determine the relevance of the single data dimensions for the overall neural architecture. This enables us to perform input pruning for the unsupervised neural gas architecture. The methods are tested on various datasets.
Cytoplasmic intermediate filament proteins of invertebrates are closer to nuclear lamins than are vertebrate intermediate filament proteins; sequence characterization of two muscle proteins of a nematode.

The giant body muscle cells of the nematode Ascaris lumbricoides show a complex three dimensional array of intermediate filaments (IFs). They contain two proteins, A (71 kd) and B (63 kd), which we now show are able to form homopolymeric filaments in vitro. The complete amino acid sequence of B and 80% of A have been determined. A and B are two homologous proteins with a 55% sequence identity over the rod and tail domains. Sequence comparisons with the only other invertebrate IF protein currently known (Helix pomatia) and with vertebrate IF proteins show that along the coiled‐coil rod domain, sequence principles rather than actual sequences are conserved in evolution. Noticeable exceptions are the consensus sequences at the ends of the rod, which probably play a direct role in IF assembly. Like the Helix IF protein the nematode proteins have six extra heptads in the coil 1b segment. These are characteristic of nuclear lamins from vertebrates and invertebrates and are not found in vertebrate IF proteins. Unexpectedly the enhanced homology between lamins and invertebrate IF proteins continues in the tail domains, which in vertebrate IF proteins totally diverge. The sequence alignment necessitates the introduction of a 15 residue deletion in the tail domain of all three invertebrate IF proteins. Its location coincides with the position of the karyophilic signal sequence, which dictates nuclear entry of the lamins. The results provide the first molecular support for the speculation that nuclear lamins and cytoplasmic IF proteins arose in eukaryotic evolution from a common lamin‐like predecessor.
Management of antipsychotic treatment discontinuation and interruptions using model-based simulations

Background Medication nonadherence is a well described and prevalent clinical occurrence in schizophrenia. These pharmacokinetic model-based simulations analyze predicted antipsychotic plasma concentrations in nonadherence and treatment interruption scenarios and with treatment reinitiation. Methods Starting from steady state, pharmacokinetic model-based simulations of active moiety plasma concentrations of oral, immediate-release risperidone 3 mg/day, risperidone long-acting injection 37.5 mg/14 days, oral paliperidone extended-release 6 mg/day, and paliperidone palmitate 117 mg (75 mg equivalents)/28 days were assessed under three treatment discontinuation/interruption scenarios, ie, complete discontinuation, one week of interruption, and four weeks of interruption. In the treatment interruption scenarios, pharmacokinetic simulations were performed using medication-specific reinitiation strategies. Results Following complete treatment discontinuation, plasma concentrations persisted longest with paliperidone palmitate, followed by risperidone long-acting injection, while oral formulations exhibited the most rapid decrease. One week of oral paliperidone or risperidone interruption resulted in near complete elimination from the systemic circulation within that timeframe, reflecting the rapid elimination rate of the active moiety. After 1 and 4 weeks of interruption, minimum plasma concentrations were higher with paliperidone palmitate than risperidone long-acting injection over the simulated period. Four weeks of treatment interruption followed by reinitiation resulted in plasma levels returning to predicted therapeutic levels within 1 week. Conclusion Due to the long half-life of paliperidone palmitate (25–49 days), putative therapeutic plasma concentrations persisted longest in simulated cases of complete discontinuation or treatment interruption. These simulations may help clinicians better conceptualize the impact of antipsychotic nonadherence on plasma concentrations, and the impact of medication-specific reinitiation strategies after intermittent nonadherence.
On Partitioning for Maximum Satisfiability

Partitioning formulas is motivated by the expectation to identify easy to solve subformulas, even though at the cost of having more formulas to solve. In this paper we suggest to apply partitioning to Maximum Satisfiability (MaxSAT), the optimization version of the well-known Satisfiability (SAT) problem. The use of partitions can be naturally combined with unsatisfiability-based algorithms for MaxSAT that are built upon successive calls to a SAT solver, where each call identifies an unsatisfiable subformula. One of the drawbacks of these algorithms results from the SAT solver returning large unsatisfiable subformulas. However, when using partitions, the solver is more likely to identify smaller unsatisfiable subformulas. Experimental results show that the use of partitions in MaxSAT significantly improves the performance of unsatisfiability-based algorithms.
Enzyme-catalyzed phosphoryl transfer reactions.

PERSPECTIVES AND SUMMARY . 877 Classes of enzyme involving reactions at phosphorus 878 COVALENT REACTION INTERMEDIATES, CRYPTIC AND OTHERWISE 879 Reactions of Phosphoric Monoesters . 879 Phosphatoses . 879 Phosphokinases • •. •. • • 881 Phosphomutases 886 Reactions of Phosphoric Diesters 890 REACTION ENERGETICS 892 "Off" Rates 893 Internal Thermodynamics . 896 THE NATURE OF THE ELEMENTARY STEP . 898 Associative versus Diss ociative Pathways 898 Stereochemistry . 902 Prochiral substrate . prochiral product . 902 Prochira/ substrate . pro-prochira/ product :. 903 Pro-prochiral substrate . pro-prochira/ product . 905 Metal Ions 907 Cation-dependent diastereoisomer preference 908 Substitution-inert complexes of nucleotides 909 Catalysis . 911
Mining Online Music Listening Trajectories

Understanding the listening habits of users is a valuable undertaking for musicology researchers, artists, consumers and online businesses alike. With the rise of Online Music Streaming Services (OMSSs), large amounts of user behavioral data can be exploited for this task. In this paper, we present S WI FT-F LOWS , an approach that models user listening habits in regards to how user attention transitions between artists. S WI FT-F LOWS combines recent advances in trajectory mining, coupled with modulated Markov models as a means to capture both how users switch attention from one artist to another, as well as how users ﬁxate their attention in a single artist over short or large periods of time. We employ S WI FT-F LOWS on OMSSs datasets showing that it provides: (1) semantically meaningful representation of habits; (2) accurately models the attention span of users.