Miracle-dz/UniFAR-FTUs huggingface dataset:
Electronic word-of-mouth (eWOM) : The relationship between anonymous and semi-anonymous eWOM and consumer attitudes

Abstract Introduction Word-of-mouth (WOM) is based on personal recommendations where the sender is known by the consumer, thus, the persuasive nature of WOM is attributed to trust between the sender and the receiver of a message. Electronic word-of-mouth (eWOM) however, eliminates the consumer’s ability to judge the credibility of sender and message. Nevertheless, a high amount of people read online reviews about products and therefore make use of eWOM. Online reviews can be anonymous or can offer additional personal details of the sender and can have an influence on the credibility of the message, which in turn, can induce different attitudes towards specific products. Purpose This study aims to identify as well as understand the relationship between anonymous and semi anonymous eWOM and its corresponding characteristics in regards to the attitudes of consumers towards a laptop computer. Methodology A qualitative research method was conducted with the intention to understand the relationship between anonymous and semi anonymous eWOM towards consumers attitude. Primary data was collected, as the authors of this study were not able to locate research studies concerning the difference between anonymous and semi-anonymous eWOM and its relationship towards consumer’s attitudes. For this reason, four focus groups were carried out with students from the Jonkoping University. During a pilot study, differences between male and female participants became visible therefore the focus groups were separated between men and women with the intention of collecting significant data. Conclusion The research was successful as it led to identify a relationship between the personal attributes of an online reviewer and the consumer attitudes towards a laptop. By reading online reviews and thus, observing the opinion of other people as well as using comparisons of different laptops, consumers form attitudes towards laptops. Moreover, it appears that consumers’ attitudes are more likely to be influenced by the message if it is perceived as credible. Several personal attributes of a reviewer such as name, photograph of a person, pseudonym, age, gender, country of residence and profession were identified to have an influence on the credibility of a message, whether they might increase or decrease the credibility. Additionally, it became visible, that women are relatively more likely to be influenced by personal attributes of a reviewer than men.
Impact of Clinical Symptoms on Interpretation of Diagnostic Assays for Clostridium difficile Infections

ABSTRACT Asymptomatic Clostridium difficile colonization is common in hospitalized patients. Existing C. difficile assay comparisons lack data on severity of diarrhea or patient outcomes, limiting the ability to interpret their results in regard to the diagnosis of C. difficile infection (CDI). The objective of this study was to measure how including patient presentation with the C. difficile assay result impacted assay performance to diagnose CDI. Stool specimens from 150 patients that met inclusion and exclusion criteria were selected. Nine methods to detect C. difficile in stool were evaluated. All patients were interviewed prospectively to assess diarrhea severity. We then assessed how different reference standards, with and without the inclusion of patient presentation, impact the sensitivity, specificity, and positive and negative predictive values of the assays to diagnose CDI. There were minimal changes in sensitivity; however, specificity was significantly lower for the assays Tox A/B II, C. diff Chek-60, BD GeneOhm Cdiff, Xpert C. difficile, and Illumigene C. difficile and for toxigenic culture (P was <0.01 for all except Tox A/B II from fresh stool, for which the P value was 0.016) when the reference standard was recovery of toxigenic C. difficile from stool plus the presence of clinically significant diarrhea compared to when the reference standard was having at least four assays positive while ignoring diarrhea severity. There were 15 patients whose assay result was reported as negative but subsequently found to be positive by at least four assays in the comparison. None suffered from any CDI-related adverse events. In conclusion, clinical presentation is important when interpreting C. difficile diagnostic assays.
Cell Signaling Pathways Involved During Invasion and Syncytialization of Trophoblast Cells

Implantation involves an extensive cross talk between the trophoblast cells and the receptive endometrium through embryonic as well as endometrial‐derived factors that regulate the invasion and migration of trophoblast cells and also syncytia formation. Any aberration in this highly regulated process may lead to pregnancy complications such as preeclampsia, intrauterine growth restriction, or even pregnancy failure. How various cytokines and growth factors act by activating various cell signaling pathways leading to the expression of the effector molecules have been reviewed, which control invasion and migration of trophoblast cells and syncytialization. The gaps in our current understanding of the various signaling pathways, activated by different cytokines/growth factors, their possible cross talk for optimized effector function(s), and future prospects in this field have been discussed.
SopE and SopE2 from Salmonella typhimurium Activate Different Sets of RhoGTPases of the Host Cell*

The bacterial enteropathogen Salmonella typhimurium employs a specialized type III secretion system to inject toxins into host cells, which trigger signaling cascades leading to cell death in macrophages, secretion of pro-inflammatory cytokines, or rearrangements of the host cell cytoskeleton and thus to bacterial invasion. Two of the injected toxins, SopE and the 69% identical protein SopE2, are highly efficient guanine nucleotide exchange factors for the RhoGTPase Cdc42 of the host cell. However, it has been a puzzle why S. typhimurium might employ two toxins with redundant function. We hypothesized that SopE and SopE2 might have different specificities for certain host cellular RhoGTPases. In vitro guanine nucleotide exchange assays and surface plasmon resonance measurements revealed that SopE is an efficient guanine nucleotide exchange factor for Cdc42 and Rac1, whereas SopE2 was interacting efficiently only with Cdc42, but notwith Rac1. Affinity precipitation of Cdc42·GTP and Rac1·GTP from lysates and characteristic cytoskeletal rearrangements of infected tissue culture cells confirmed that SopE is highly efficient at activating Cdc42 and Rac1 in vivo, whereas SopE2 was efficiently activating Cdc42, but not Rac1. We conclude that the translocated effector proteins SopE and SopE2 allowS. typhimurium to specifically activate different sets of RhoGTPase signaling cascades.
Adaptive Signal Processing for Acoustic Enhancement

The quality of speech signals captured, for instance, by hearing-aid microphones or other mobile devices, can be easily degraded by the environmental noise in daily-life scenarios. Here, it will be beneficial to apply adaptive signal processing algorithms to reduce, for instance, undesired acoustic noise or reverberation in the signals. This will help to increase sound quality and intelligibility in speech communication or recognition systems. In the project, we focus on implementation and verification of two-channel signal processing related to the binaural-hearing system of human beings, e.g. [1-2]. Matlab/Simulink will be used for technical computing and to enable a fast transition to a target, for instance PC, Speedgoat-PC, or Raspberry Pi. The algorithm performance will eventually be investigated with speech in the presence of various noise types or reverberation levels.
Advances in Medical Education and Practice Dovepress Predicting Performance at Medical School: Can We Identify At-risk Students?

Background: The purpose of this study was to examine the predictive potential of multiple indicators (eg, preadmission scores, unit, module and clerkship grades, course and examination scores) on academic performance at medical school, with a view to identifying students at risk. Methods: An analysis was undertaken of medical student grades in a 6-year medical school program at the Arab Emirates, over the past 14 years. Results: While high school scores were significantly (P , 0.001) correlated with the final integrated examination, predictability was only 6.8%. Scores for the United Arab Emirates university placement assessment (Common Educational Proficiency Assessment) were only slightly more promising as predictors with 14.9% predictability for the final integrated examination. Each unit or module in the first four years was highly correlated with the next unit or module, with 25%–60% predictability. Course examination scores (end of years 2, 4, and 6) were significantly correlated (P , 0.001) with the average scores in that 2-year period (59.3%, 64.8%, and 55.8% predictability, respectively). Final integrated examination scores were significantly correlated (P , 0.001) with National Board of Medical Examiners scores (35% predictability). Multivariate linear regression identified key grades with the greatest predictability of the final integrated examination score at three stages in the program. Conclusion: This study has demonstrated that it may be possible to identify " at-risk " students relatively early in their studies through continuous data archiving and regular analysis. The data analysis techniques used in this study are not unique to this institution.
Leaps of logic: quantifying the behavioural relevance of hippocampal neurogenesis

Few studies that examine the neurogenesis-behaviour relationship formally establish covariation between neurogenesis and behaviour or rule out competing explanations. The behavioural relevance of neurogenesis might therefore be overestimated if other mechanisms account for some, or even all, of the experimental effects. All publicly available data was reanalysed using causal mediation analysis, which can estimate the unique contribution of new hippocampal neurons to behaviour separately from other mechanisms that might be operating. The results from eleven individual studies were then combined to increase precision (representing data from 215 animals) and showed that neurogenesis made a negligible contribution to behaviour (standarised effect = 0.15; 95% CI = -0.04 to 0.34; p = 0.128); other mechanisms accounted for the majority of experimental effects (standardised effect = 1.06; 95% CI = 0.74 to 1.38; p = 1.7 $\times 10^{-11}$).
Stakeholder theory and agile software development

Stakeholder Theory provides models for identifying and mapping stakeholders, and for recognizing who and what really counts in an organization. The objective of this research is to develop a model that helps organizations understand the diversity of stakeholders that influence their product development efforts, provide a means of quantifying the nature of their stake, and understand how agile and lean processes facilitate application of stakeholder theory in software product development.
Assessing the Optimism of Payday Loan Borrowers

This Article compares the results from a survey administered to payday loan borrowers at the time of their loans to subsequent borrowing and repayment behavior. It thus presents the first direct evidence of the accuracy of payday loan borrowers’ understanding of how the product will be used. The data show, among other things, that about 60 percent of borrowers accurately predict how long it will take them finally to repay their payday loans. The evidence directly contradicts the oft-stated view that substantially all extended use of payday loans is the product of lender misrepresentation or borrower self-deception about how the product will be used. It thus has direct implications for the proper scope of effective regulation of the product, a topic of active concern for state and federal regulators.
Effect of Multimodal Exercise Program on Physical Function, Falls, and Injuries in Older Women

1. Sumer F, Arik G, Aycicek S et al. Study of factors associated with incomplete bladder emptying in older women. J Am Geriatr Soc 2016;64:456– 457. 2. Park J, Palmer MH. Factors associated with incomplete bladder emptying in older women with overactive bladder symptoms. J Am Geriatr Soc 2015;63:1426–1431. 3. Groutz A, Blaivas JG, Chaikin DC. Bladder outlet obstruction in women: Definition and characteristics. Neurourol Urodyn 2000;19: 213–230. 4. McCrery RJ, Appell RA. Bladder outlet obstruction in women: Iatrogenic, anatomic, and neurogenic. Curr Urol Rep 2006;7:363–369. 5. Yoshimura N, Chancellor MB. Differential diagnosis and treatment of impaired bladder emptying. Rev Urol 2004;6(Suppl 1):S24–S31. 6. Shakeri S, Rasekhi AR, Yazdani M et al. The incidence of diverticula of urinary bladder in patients with benign prostatic hypertrophy and the comparison between cystoscopy and cystography in detecting bladder diverticula. Iran Red Crescent Med 2007;9:36–41. 7. Prakash, Rajini T, Bhardwaj AK et al. Urinary bladder diverticulum and its association with malignancy: An anatomical study on cadavers. Rom J Morphol Embryol2010;51:543–545. 8. Echaiz JF, Cass C, Henderson JP et al. Low correlation between self-report and medical record documentation of urinary tract infection symptoms. Am J Infect Control 2015;43:983–986. 9. Giesen LG, Cousins G, Dimitrov BD et al. Predicting acute uncomplicated urinary tract infection in women: A systematic review of the diagnostic accuracy of symptoms and signs. BMC Fam Pract 2010;11:78.
Vitamin D status and its relationship with parathyroid hormone and bone mineral status in older adolescents

Osteoporosis is an important contributor to the global burden of disease, and in the UK alone results in one in three women and one in twelve men aged >50 years experiencing a fragility fracture. Optimising peak bone mass in early adulthood is thought to reduce osteoporosis risk by offsetting bone losses in later life. Ensuring sufficient vitamin D status (measured as 25-hydroxyvitamin D (25OHD) in plasma), among other factors, is believed to facilitate the achievement of optimum peak bone mass. Lower 25OHD is associated with a higher plasma concentration of parathyroid hormone (PTH). As PTH is associated with increased bone turnover and bone loss, maintenance of sufficient 25OHD is thought to have a protective effect on bone health. However, there is a lack of consensus internationally on what constitutes an optimum 25OHD concentration, and values between 30 and 80 nmol/l have been suggested. These values have been based on findings from various studies in adults in which PTH has been observed to plateau at a 25OHD concentration of >30 nmol/l; however, not all studies have found such a plateau. Although studies in younger adolescents (14–16 years) have shown an inverse relationship between PTH and 25OHD, the concentration of 25OHD required for achievement of optimum peak bone mass is unknown. The present review examines the evidence defining vitamin D insufficiency thresholds, and the relevance of such thresholds to adolescent bone health.
HbA1c measurement improves the detection of type 2 diabetes in high-risk individuals with nondiagnostic levels of fasting plasma glucose: the Early Diabetes Intervention Program (EDIP).

OBJECTIVE Whereas new diagnostic criteria based on a fasting plasma glucose (FPG) of > 126 mg/dl (7.8 mmol/l) have improved the detection of diabetes, multiple reports indicate that many people with diabetes diagnosed by 2-h oral glucose tolerance test (OGTT) glucose measurements > or = 11.1 mmol/l (200 mg/dl) would remain undiagnosed based on this FPG criteria. Thus, improved methods to detect diabetes are particularly needed for high-risk individuals. We evaluated whether the combination of FPG and HbA1c measurements enhanced detection of diabetes in those individuals at risk for diabetes with nondiagnostic or minimally elevated FPG. RESEARCH DESIGN AND METHODS We analyzed FPG, OGTT, and HbA1c data from 244 subjects screened for participation in the Early Diabetes Intervention Program (EDIP). RESULTS Of 244 high-risk subjects studied by FPG measurements and OGTT, 24% of the individuals with FPG levels of 5.5-6.0 mmol/l (100-109 mg/dl) had OGTT-diagnosed diabetes, and nearly 50% of the individuals with FPG levels of 6.1-6.9 mmol/l (110-125 mg/dl) had OGTT-diagnosed diabetes. In the subjects with OGTT-diagnosed diabetes and FPG levels between 5.5 and 8.0 mmol/l, detection of an elevated HbA1c (>6.1% or mean + 2 SDs) led to a substantial improvement in diagnostic sensitivity over the FPG threshold of 7.0 mmol/l (61 vs. 45%, respectively, P = 0.002). Concordant FPG levels > or = 7.0 mmol/l (currently recommended for diagnosis) occurred in only 19% of our cohort with type 2 diabetes. CONCLUSIONS Diagnostic criteria based on FPG criteria are relatively insensitive in the detection of early type 2 diabetes in at-risk subjects. HbA1c measurement improves the sensitivity of screening in high-risk individuals.
Thickness and Information in Dynamic Matching Markets

We introduce a simple model of dynamic matching in networked markets, where agents arrive and depart stochastically and the composition of the trade network depends endogenously on the matching algorithm. If the planner can identify agents who are about to depart, then waiting to thicken the market substantially reduces the fraction of unmatched agents. If not, then matching agents greedily is close to optimal. We specify conditions under which local algorithms that choose the right time to match agents, but do not exploit the global network structure, are close to optimal. Finally, we consider a setting where agents have private information about their departure times and design a mechanism to elicit this information.
Unsolved Mystery What Controls Variation in Human Skin Color

Diversity of human appearance and form has intrigued biologists for centuries, but nearly 100 years after the term “genetics’’ was coined by William Bateson in 1906, the genes that underlie this diversity are an unsolved mystery. One of the most obvious phenotypes that distinguish members of our species, differences in skin pigmentation, is also one of the most enigmatic. There is a tremendous range of human skin color in which variation can be correlated with climates, continents, and/or cultures, yet we know very little about the underlying genetic architecture. Is the number of common skin color genes closer to fi ve, 50, or 500? Do gainand loss-offunction alleles for a small set of genes give rise to phenotypes at opposite ends of the pigmentary spectrum? Has the effect of natural selection on similar pigmentation phenotypes proceeded independently via similar pathways? And, fi nally, should we care about the genetics of human pigmentation if it is only skin-deep? Why Should We Care?
MUSCLE W49: A MULTI-SCALE CONTINUUM AND LINE EXPLORATION OF THE MOST LUMINOUS STAR FORMATION REGION IN THE MILKY WAY. I. DATA AND THE MASS STRUCTURE OF THE GIANT MOLECULAR CLOUD

The Multi-scale Continuum and Line Exploration of W49 is a comprehensive gas and dust survey of the giant molecular cloud (GMC) of W49A, the most luminous star-formation region in the Milky Way. The project covers, for the first time, the entire GMC at different scales and angular resolutions. In this paper, we present (1) an all-configuration Submillimeter Array mosaic in the 230 GHz (1.3 mm) band covering the central ∼3′ × 3′ (∼10 pc, known as W49N), where most of the embedded massive stars reside and (2) Purple Mountain Observatory 14 m telescope observations in the 90 GHz band, covering the entire GMC with maps of up to ∼35′ × 35′ in size, or ∼113 pc. We also make use of archival data from the Very Large Array, JCMT-SCUBA, the IRAM 30 m telescope, and the Caltech Submillimeter Observatory BOLOCAM Galactic Plane Survey. We derive the basic physical parameters of the GMC at all scales. Our main findings are as follows. (1) The W49 GMC is one of the most massive in the Galaxy, with a total mass Mgas ∼ 1.1 × 106 M☉ within a radius of 60 pc. Within a radius of 6 pc, the total gas mass is Mgas ∼ 2 × 105 M☉. At these scales, only ∼1% of the material is photoionized. The mass reservoir is sufficient to form several young massive clusters (YMCs) as massive as a globular cluster. (2) The mass of the GMC is distributed in a hierarchical network of filaments. At scales <10 pc, a triple, centrally condensed structure peaks toward the ring of HC H ii regions in W49N. This structure extends to scales from ∼10 to 100 pc through filaments that radially converge toward W49N and its less-prominent neighbor W49S. The W49A starburst most likely formed from global gravitational contraction with localized collapse in a “hub–filament” geometry. (3) Currently, feedback from the central YMCs (with a present mass Mcl ≳ 5 × 104 M☉) is still not enough to entirely disrupt the GMC, but further stellar mass growth could be enough to allow radiation pressure to clear the cloud and halt star formation. (4) The resulting stellar content will probably remain as a gravitationally bound massive star cluster or a small system of bound clusters.
Cerebral radiation necrosis

Cerebral radiation‐induced injury ranges from acute reversible edema to late irreversible radiation necrosis (RN). Cerebral RN is poorly responsive to treatment, is associated with permanent neurological deficits and occasionally progresses to death. We review the literature regarding cerebral RN after radiotherapy for various brain and head and neck lesions and discuss its clinical features, imaging characteristics, pathophysiology and treatment. For new enhancing lesions on computed tomography or magnetic resonance imaging, apart from tumor progression or recurrence, RN needs to be considered in the differential diagnosis. Further studies are required to design chemoradiotherapy protocols that are effective in treating tumors while minimizing risk of RN. Current available treatments for RN, steroid and surgery, only relieve the mass effect. None of the experimental treatments to date have consistently been shown to reverse the pathologic process of RN.
Calcium carbonate suppresses haem toxicity markers without calcium phosphate side effects on colon carcinogenesis

Red meat intake is associated with an increased risk of colorectal cancer. We have previously shown that haemin, Hb and red meat promote carcinogen-induced preneoplastic lesions, aberrant crypt foci (ACF), in the colon of rats. We have also shown that dietary calcium phosphate inhibits haemin-induced promotion and normalises faecal lipoperoxides and cytotoxicity. Unexpectedly, high-calcium phosphate control diet-fed rats had more preneoplastic lesions in the colon than low-Ca control diet-fed rats. The present study was designed to find a Ca supplementation with no adverse effect, by testing several doses and types of Ca salts. One in vitro study and two short-term studies in rats identified calcium carbonate as the most effective Ca salt to bind haem in vitro and to decrease faecal biomarkers previously associated with increased carcinogenesis: faecal water cytotoxicity and thiobarbituric acid-reactive substances. A long-term carcinogenesis study in dimethylhydrazine-injected rats demonstrated that a diet containing 100 μmol/g calcium carbonate did not promote ACF, in contrast with a previously tested calcium phosphate diet. The results suggest that calcium carbonate, and not calcium phosphate, should be used to reduce haem-associated colorectal cancer risk in meat eaters. They support the concept that the nature of the associated anion to a protective metal ion is important for chemoprevention.