Miracle-dz/UniFAR-FTUs huggingface dataset:
Parents' Experience of Cancer Who Have Young Children: A Literature Review

Background: The National Cancer Institute estimates that 24% of adults with cancer are parenting children younger than 18 years. When a parent is diagnosed with cancer, this is a major stressor and often creates multiple problems for families. Objective: The aim of this article was to conduct a comprehensive review of the literature on the experience of parents with cancer who are caring for young children. Methods: A comprehensive review of the literature was undertaken using systematic review principles. The search strategy included five electronic bibliographic databases, using the search terms: parent, cancer, parents and cancer and communication. Results: Thirteen studies were found that focused on parents' experience of cancer. Eleven of the 13 studies used solely qualitative methodology, and 2 studies used mixed methods. Of the studies identified, the majority focused on the experience of mothers, and mainly those with a diagnosis of breast cancer. Analysis of the 13 studies on parents' experience following a diagnosis of cancer revealed 3 predominant themes: (a) being a good parent, (b) telling the children, and (c) maintaining routine at home. Conclusion: The 3 themes highlight how parents with cancer struggle to know how best to talk to their children about cancer and the perceived lack of guidance and support from professionals, the feelings of guilt about not being "a good parent," and the effort required to maintain routine at home as a way of protecting their children. Implications for Practice: Support for parents with cancer on relevant parenting issues should be acknowledged as an important facet of care for oncology nurses, as a mechanism of reducing parental stress and psychological distress for the whole family.
Chikungunya Disease: Infection-Associated Markers from the Acute to the Chronic Phase of Arbovirus-Induced Arthralgia

At the end of 2005, an outbreak of fever associated with joint pain occurred in La Réunion. The causal agent, chikungunya virus (CHIKV), has been known for 50 years and could thus be readily identified. This arbovirus is present worldwide, particularly in India, but also in Europe, with new variants returning to Africa. In humans, it causes a disease characterized by a typical acute infection, sometimes followed by persistent arthralgia and myalgia lasting months or years. Investigations in the La Réunion cohort and studies in a macaque model of chikungunya implicated monocytes-macrophages in viral persistence. In this Review, we consider the relationship between CHIKV and the immune response and discuss predictive factors for chronic arthralgia and myalgia by providing an overview of current knowledge on chikungunya pathogenesis. Comparisons of data from animal models of the acute and chronic phases of infection, and data from clinical series, provide information about the mechanisms of CHIKV infection–associated inflammation, viral persistence in monocytes-macrophages, and their link to chronic signs.
Regional differences in rabbit atrial action potential properties: Mechanisms, consequences and pharmacological implications

Regional differences in electrical action potential (AP) properties can provide a substrate for atrial arrhythmias. We quantify such differences by developing detailed AP models for the left (LA) and right (RA) rabbit atrial cells in order to study the underlying electrophysiological mechanisms, as well as their impacts on vulnerable properties of the atrial tissue. The transient outward current, Ito, is identified as the major factor contributing to the AP differences between the LA and RA cells, which suggests a potential pharmacological target for reducing heterogeneity and vulnerability of the atria.
A Meta-Analysis Approach for Characterizing Pan-Cancer Mechanisms of Drug Sensitivity in Cell Lines

Understanding the heterogeneous drug response of cancer patients is essential to precision oncology. Pioneering genomic analyses of individual cancer subtypes have begun to identify key determinants of resistance, including up-regulation of multi-drug resistance (MDR) genes and mutational alterations of drug targets. However, these alterations are sufficient to explain only a minority of the population, and additional mechanisms of drug resistance or sensitivity are required to explain the remaining spectrum of patient responses to ultimately achieve the goal of precision oncology. We hypothesized that a pan-cancer analysis of in vitro drug sensitivities across numerous cancer lineages will improve the detection of statistical associations and yield more robust and, importantly, recurrent determinants of response. In this study, we developed a statistical framework based on the meta-analysis of expression profiles to identify pan-cancer markers and mechanisms of drug response. Using the Cancer Cell Line Encyclopaedia (CCLE), a large panel of several hundred cancer cell lines from numerous distinct lineages, we characterized both known and novel mechanisms of response to cytotoxic drugs including inhibitors of Topoisomerase 1 (TOP1; Topotecan, Irinotecan) and targeted therapies including inhibitors of histone deacetylases (HDAC; Panobinostat) and MAP/ERK kinases (MEK; PD-0325901, AZD6244). Notably, our analysis implicated reduced replication and transcriptional rates, as well as deficiency in DNA damage repair genes in resistance to TOP1 inhibitors. The constitutive activation of several signaling pathways including the interferon/STAT-1 pathway was implicated in resistance to the pan-HDAC inhibitor. Finally, a number of dysregulations upstream of MEK were identified as compensatory mechanisms of resistance to the MEK inhibitors. In comparison to alternative pan-cancer analysis strategies, our approach can better elucidate relevant drug response mechanisms. Moreover, the compendium of putative markers and mechanisms identified through our analysis can serve as a foundation for future studies into these drugs.
Elevated serum acute phase protein levels as predictors of disseminated breast cancer

Serum levels of four acute phase proteins, alpha1‐acid glycoprotein (AAGP), alpha1‐antitrypsin (AAT), haptoglobin (Hpt), and C3, were measured prior to biopsy in 38 women subsequently shown to have Stage I and II breast cancer and prior to treatment in 16 women with Stage IV disease. Sixty‐one women with benign and 28 women with no breast disease served as controls. Mean serum levels of all four proteins were significantly elevated in women with stage IV disease as compared to women with Stage I or II disease or controls. Normal versus elevated levels for each protein were defined and AAGP was found to be the single most sensitive predictor of disseminated disease among the four. AAGP was elevated in 81.3% of Stage IV, 25% of Stage II, 14.3% of Stage I, and 12.4% of controls. Women with multiple proteins elevated were most likely to have advanced stage disease. Composite analysis of all four proteins using number of proteins abnormal or logistic regression analysis gave results similar to AAGP, both showing increasing numbers of proteins abnormal with increasing stage of breast cancer. These results indicate that measurement of serum acute phase proteins may be useful in initial staging of breast cancer patients and in following patients for indications of disseminated disease.
PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis

Developing erythrocytes take up exceptionally large amounts of iron, which must be transferred to mitochondria for incorporation into heme. This massive iron flux must be precisely controlled to permit the coordinated synthesis of heme and hemoglobin while avoiding the toxic effects of chemically reactive iron. In cultured animal cells, iron chaperones poly rC–binding protein 1 (PCBP1) and PCBP2 deliver iron to ferritin, the sole cytosolic iron storage protein, and nuclear receptor coactivator 4 (NCOA4) mediates the autophagic turnover of ferritin. The roles of PCBP, ferritin, and NCOA4 in erythroid development remain unclear. Here, we show that PCBP1, NCOA4, and ferritin are critical for murine red cell development. Using a cultured cell model of erythroid differentiation, depletion of PCBP1 or NCOA4 impaired iron trafficking through ferritin, which resulted in reduced heme synthesis, reduced hemoglobin formation, and perturbation of erythroid regulatory systems. Mice lacking Pcbp1 exhibited microcytic anemia and activation of compensatory erythropoiesis via the regulators erythropoietin and erythroferrone. Ex vivo differentiation of erythroid precursors from Pcbp1-deficient mice confirmed defects in ferritin iron flux and heme synthesis. These studies demonstrate the importance of ferritin for the vectorial transfer of imported iron to mitochondria in developing red cells and of PCBP1 and NCOA4 in mediating iron flux through ferritin.
Herschel : the first science highlights Special feature L etter to the E ditor Resolving the cold debris disc around a planet-hosting star PACS photometric imaging observations of q 1 Eridani ( HD 10647 , HR 506 )

Context. About two dozen exo-solar debris systems have been spatially resolved. These debris discs commonly display a variety of structural features such as clumps, rings, belts, excentric distributions and spiral patterns. In most cases, these features are believed to be formed, shaped and maintained by the dynamical influence of planets orbiting the host stars. In very few cases has the presence of the dynamically important planet(s) been inferred from direct observation. Aims. The solar-type star q1 Eri is known to be surrounded by debris, extended on scales of <∼30′′ . The star is also known to host at least one planet, albeit on an orbit far too small to make it responsible for structures at distances of tens to hundreds of AU. The aim of the present investigation is twofold: to determine the optical and material properties of the debris and to infer the spatial distribution of the dust, which may hint at the presence of additional planets. Methods. The Photodetector Array Camera and Spectrometer (PACS) aboard the Herschel Space Observatory allows imaging observations in the far infrared at unprecedented resolution, i.e. at better than 6′′ to 12′′ over the wavelength range of 60 μm to 210 μm. Together with the results from ground-based observations, these spatially resolved data can be modelled to determine the nature of the debris and its evolution more reliably than what would be possible from unresolved data alone. Results. For the first time has the q Eri disc been resolved at far infrared wavelengths. The PACS observations at 70 μm, 100 μm and 160 μm reveal an oval image showing a disc-like structure in all bands, the size of which increases with wavelength. Assuming a circular shape yields the inclination of its equatorial plane with respect to that of the sky, i > 53◦. The results of image de-convolution indicate that i likely is larger than 63◦, where 90◦ corresponds to an edge-on disc. Conclusions. The observed emission is thermal and optically thin. The resolved data are consistent with debris at temperatures below 30 K at radii larger than 120 AU. From image de-convolution, we find that q1 Eri is surrounded by an about 40 AU wide ring at the radial distance of ∼85 AU. This is the first real Edgeworth-Kuiper Belt analogue ever observed.
Factors Associated with Family Caregivers' Burden and Depression In Korea

This study determines the relative effects of functional impairment, cognitive impairment, and duration of care of the elderly on caregivers' depression, and identifies the factors that influence this relationship. The variables were entered individually, based on a logical order in the path modeling. For mediators, the order of three types of social support was assumed to be financial support, instrumental support, and emotional support. The order of five dimensions of caregiver burden was assumed to be impact on finances, feelings of abandonment, impact on schedule, impact on health, and sense of entrapment. Findings indicate that functional impairment had both direct and indirect effects on caregiver depression, and direct effects on impact on schedule, impact on health, and sense of entrapment. The effect of cognitive impairment on caregiver depression was primarily indirect but had direct impact on sense of entrapment. Duration of care had no direct effect on caregiver depression and burden, but did have indirect effects on impact on finances, feelings of abandonment, and impact on health through emotional support. Caregivers of elders with functional impairment were more likely to give care for longer periods, and those who give care for longer periods were likely to receive less emotional support and experience more burden in the dimensions of impact on finances, feelings of abandonment, and impact on health. Caregivers who experience greater impact on finances and impact on health ultimately were at higher risk of depression. The results have important implications for intervention models aimed to increase emotional support for the caregiver.
Towards an Integrated Robot with Multiple Cognitive Functions

We present integration mechanisms for combining heterogeneous components in a situated information processing system, illustrated by a cognitive robot able to collaborate with a human and display some understanding of its surroundings. These mechanisms include an architectural schema that encourages parallel and incremental information processing, and a method for binding information from distinct representations that when faced with rapid change in the world can maintain a coherent, though distributed, view of it. Provisional results are demonstrated in a robot combining vision, manipulation, language, planning and reasoning capabilities interacting with a human and manipulable objects.
Speed scaling for weighted flow time

In addition to the traditional goal of efficiently managing time and space, many computers now need to efficiently manage power usage. For example, Intel's SpeedStep and AMD's PowerNOW technologies allow the Windows XP operating system to dynamically change the speed of the processor to prolong battery life. In this setting, the operating system must not only have a job selection policy to determine which job to run, but also a speed scaling policy to determine the speed at which the job will be run. These policies must be online since the operating system does not in general have knowledge of the future. In current CMOS based processors, the speed satisfies the well known cube-root-rule, that the speed is approximately the cube root of the power [Mud01, BBS+00]. Thus, in this work, we make the standard generalization that the power is equal to speed to some power α ≥ 1, where one should think of α as being approximately 3 [YDS95, BKP04]. Energy is power integrated over time. The operating system is faced with a dual objective optimization problem as it both wants to conserve energy, and optimize some Quality of Service (QoS) measure of the resulting schedule.
Gated recurrent units based hybrid acoustic models for robust speech recognition

Recurrent neural networks (RNNs) have shown an ability to model temporal dependencies. However the problem of exploding or vanishing gradients has limited their application. In recent years, long short-term memory RNNs (LSTM RNNs) have been proposed to solve this problem, and have achieved excellent results. However, because of the large size of LSTM RNNs, they more easily suffer from overfitting, especially for low resource tasks. In addition, because the output of LSTM units is bounded, there is often still a vanishing gradient issue over multiple layers. In this work, we evaluate an architecture called gated recurrent units (GRU) to solve these two problems. In comparison with LSTM RNN, the size of the GRU network is smaller, so this model can more easily avoid overfitting. Furthermore, the output of the GRU is not constrained to be bounded, which helps alleviate the negative impact of vanishing gradients across multiple layers. We propose using deep bidirectional GRUs as hybrid acoustic models and compare the similarities and differences between LSTM and GRU. We evaluate this architecture on the CHIME2 dataset, a robust low resource speech recognition task. Results demonstrate that our architecture outperforms LSTM, relatively decreasing the WER about 6% in the bidirectional case and, when combined with a baseline GMM system, achieves 1.1% absolute WER reduction comparing to a strong baseline mixing system.
Key Replicating Attack on an Identity-Based Three-Party Authenticated Key Agreement Protocol

In 2009, Mengbo Hou and Qiuliang Xu found the key replicating attack in the BR93 security model on a Certificateless two-party authenticated key agreement protocol proposed by Y.J Shi and J.H Li. In 2010, Marko Hölbl, Tatjana Welzer and Boštjan Brumen proposed a one-round identity-based three-party authenticated key agreement protocol using pairings called IDAK3-P1 and declared that the protocol had the attributes of known-key security, forward secrecy, key-compromise impersonation resilience, unknown key-share resilience and key control. In this paper, we make a systematic analysis on IDAK3-P1 and find it has similar structure as the Y.J Shi and J.H Li's protocol. We introduce Mengbo Hou and Qiuliang Xu's attack method in identifying the vulnerability of IDAK3-P1. Our analysis shows that the IDAK3-P1 is vulnerable to the key replicating attack in the BR model. Therefore, it doesn't possess the security attributes of implicit key authentication and key control as declared.
Miniaturized force/torque sensor for in vivo measurements of tissue characteristics

This paper presents the development of a surgical instrument to measure interaction forces/torques with organic tissue during operation. The focus is on the design progress of the sensor element, consisting of a spoke wheel deformation element with a diameter of 12 mm and eight inhomogeneous doped piezoresistive silicon strain gauges on an integrated full-bridge assembly with an edge length of 500 μm. The silicon chips are contacted to flex-circuits via flip chip and bonded on the substrate with a single component adhesive. A signal processing board with an 18 bit serial A/D converter is integrated into the sensor. The design concept of the handheld surgical sensor device consists of an instrument coupling, the six-axis sensor, a wireless communication interface and battery. The nominal force of the sensing element is 10 N and the nominal torque is 1 N-m in all spatial directions. A first characterization of the force sensor results in a maximal systematic error of 4.92 % and random error of 1.13 %.
Performance Analysis of Multiuser Diversity in Multiuser Two-Hop Decode-and-Forward Cooperative Multi-Relay Wireless Networks

— Cooperative diversity (CD) has been adopted in many communication systems because it helps in improving performance of the wireless communication systems with the help of the relays that emulate the multiple antenna terminals. This work aims to provide the derivation of the performance analysis expressions of the multiuser diversity (MUD) in the two-hop cooperative multi-relay wireless networks (TCMRNs). Considering the work analysis, we provide analytically the derivation of a closed form expression of the two most commonly used performance metrics namely, the outage probability and the symbol error probability (SEP) for the fixed decode-and-forward (FDF) protocol with MUD.
Afferent and efferent connections of the parapineal organ in lampreys: A tract tracing and immunocytochemical study

The neural connections of the parapineal organ of two species of lampreys were studied with the fluorescent dye 1,1′‐dioctadecyl‐3,3,3′,3′‐tetramethylindocarbocyanine perchlorate (DiI) and with immunocytochemistry. The lamprey parapineal organ consists of a vesicle and a ganglion that are connected to the left habenula. Labeling experiments included the application of DiI to the parapineal organ, left and right fasciculus retroflexus, left habenula, and the left pretectal region. Afferent parapineal fibers run in the left fasciculus retroflexus to the interpeduncular nucleus. The parapineal fibers of this fascicle arose from parapineal ganglion cells, whereas DiI application to the left habenula labeled both neurons of this ganglion and bipolar cells in the parapineal vesicle. Efferent neurons were observed in the left habenula, and bilaterally in the subhippocampal nucleus and the dorsal pretectum. Labeling with DiI also revealed a hippocampal projection.
The JCMT Gould Belt Survey: evidence for radiative heating and contamination in the W40 complex

We present SCUBA-2 450 μm and 850 μm observations of the W40 complex in the Serpens-Aquila region as part of the James Clerk Maxwell Telescope (JCMT) Gould Belt Survey (GBS) of nearby star-forming regions. We investigate radiative heating by constructing temperature maps from the ratio of SCUBA-2 fluxes using a fixed dust opacity spectral index, β = 1.8, and a beam convolution kernel to achieve a common 14.8 arcsec resolution.We identify 82 clumps ranging between 10 and 36 K with a mean temperature of 20 ± 3 K. Clump temperature is strongly correlated with proximity to the external OB association and there is no evidence that the embedded protostars significantly heat the dust.We identify 31 clumps that have cores with densities greater than 105cm−3. 13 of these cores contain embedded Class 0/I protostars. Many cores are associated with bright-rimmed clouds seen in Herschel 70 μm images. From JCMT HARP observations of the 12CO 3–2 line, we find contamination of the 850 μm band of up to 20 per cent. We investigate the free–free contribution to SCUBA-2 bands from large-scale and ultracompact HII regions using archival VLA data and find the contribution is limited to individual stars, accounting for 9 per cent of flux per beam at 450 μm or 12 per cent at 850 μm in these cases. We conclude that radiative heating has potentially influenced the formation of stars in the Dust Arc sub-region, favouring Jeans stable clouds in the warm east and fragmentation in the cool west.
Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle

Pericytes are perivascular cells that envelop and make intimate connections with adjacent capillary endothelial cells. Recent studies show that they may have a profound impact in skeletal muscle regeneration, innervation, vessel formation, fibrosis, fat accumulation, and ectopic bone formation throughout life. In this review, we summarize and evaluate recent advances in our understanding of pericytes' influence on adult skeletal muscle pathophysiology. We also discuss how further elucidating their biology may offer new approaches to the treatment of conditions characterized by muscle wasting.
Discovering Gathering Pattern Using a Taxicab Service Rate Analysis Method based on Neural Network

Moving objects gathering pattern represents a group events or incidents that involve congregation of moving objects, enabling the analysis of traffic system. However, how to improve the effectiveness and efficiency of the gathering pattern discovering method still remains as a challenging issue since the large number of moving objects will generate high volume of trajectory data. In order to address this issue, the authors propose a method to discovering the gathering pattern by analyzing the taxicab demand. This paper first introduces the concept of Taxicab Service Rate (TSR). In this method, they use the KS measures to test the distribution of TSR and calculate the mean value of the TSR of a certain time period. Then, the authors use a neural network based method Neural Network Gathering Discovering (NNGD) to detect the gathering pattern. The neural network is based on the knowledge of historical gathering pattern data. The authors have implemented their method with experiments based on real trajectory data. The results show the both effectiveness and efficiency of their method.