Miracle-dz/UniFAR-FTUs huggingface dataset:
Influenza treatment and prophylaxis with neuraminidase inhibitors: a review

Influenza virus is a pathogen that causes morbidity and mortality worldwide. Whereas vaccination is important for prevention of disease, given its limitations, antiviral therapy is at the forefront of treatment and also plays a role in prevention. Currently, two classes of antiviral medications, the adamantanes and the neuraminidase inhibitors, are approved for treatment. Given the resistance patterns of circulating influenza, adamantanes are not recommended. Within the US, two neuraminidase inhibitors are currently approved for both treatment and prevention, while worldwide there are four available. In this review, we will briefly discuss the epidemiology and pathology of influenza and then discuss neuraminidase inhibitors: their mechanism of action, resistance, development, and future applications.
Nutritional and clinical relevance of lutein in human health

Lutein is one of the most widely found carotenoids distributed in fruits and vegetables frequently consumed. Its presence in human tissues is entirely of dietary origin. Distribution of lutein among tissues is similar to other carotenoids but, along with zeaxanthin, they are found selectively at the centre of the retina, being usually referred to as macular pigments. Lutein has no provitamin A activity in man but it displays biological activities that have attracted great attention in relation to human health. Epidemiological studies have shown inconsistent associations between high intake or serum levels of lutein and lower risk for developing cardiovascular disease, several types of cancer, cataracts and age-related maculopathy. Also, lutein supplementation has provided both null and positive results on different biomarkers of oxidative stress although it is effective in increasing macular pigment concentration and in improving visual function in some, but not all, subjects with different eye pathologies. Overall, data suggest that whereas serum levels of lutein have, at present, no predictive, diagnostic or prognostic value in clinical practice, its determination may be very helpful in assessing compliance and efficacy of intervention as well as potential toxicity. In addition, available evidence suggests that a serum lutein concentration between 0·6 and 1·05 μmol/l seems to be a safe, dietary achievable and desirable target potentially associated with beneficial impact on visual function and, possibly, on the development of other chronic diseases. The use of lutein as a biomarker of exposure in clinical practice may provide some rationale for assessing its relationship with human health as well as its potential use within the context of evidence-based medicine.
Bending-induced deformation twinning in body-centered cubic tungsten nanowires

ABSTRACT The competition between dislocation slip and deformation twinning in body-centered cubic (BCC) nanocrystals can be strongly influenced by the deformation conditions. In this study, we investigate the deformation of [112]-oriented BCC tungsten nanowires under different loading modes. It shows that dislocation plasticity is a predominant deformation mode under uniaxial tension, while deformation twinning prevails when non-uniaxial stress is applied. The interfaces of bending-induced twinning are composed of numerous stepwise {112} twin boundaries. These findings shed light on the deformation mechanism of BCC nanocrystals under complex loading conditions. GRAPHICAL ABSTRACT IMPACT STATEMENT In situ nanomechanical testing and quantitative analysis reveal a deformation mechanism transition in tungsten nanowires, from dislocation slip under the uniaxial loading to deformation twinning under the non-uniaxial loading.
What Determines the Reservation Wages of Unemployed Workers? New Evidence from German Micro Data

This paper provides new empirical evidence on the relationship between reservation wages of unemployed workers and macroeconomic factors – including aggregate and local unemployment rates, generosity of the unemployment compensation system and characteristics of the wage structure – as well as individual-specific determinants, including proxies for general and specific human capital, length of unemployment spell and alternative income sources. The longitudinal aspect of the dataset (the German Socio-Economic Panel) provides an interesting perspective on how reservation wages change over time and how they correlate with accepted wage offers for workers who make the transition from unemployment to employment. The findings have important policy implications as well, since they shed some light on the disincentive effects of the German tax and transfer system for the labor supply and employment decisions of unemployed workers at different points of the skill/offer wage distribution.
Integrative analysis of lncRNAs and miRNAs with coding RNAs associated with ceRNA crosstalk network in triple negative breast cancer

Triple negative breast cancer (TNBC) is a particular subtype of breast malignant tumor with poorer prognosis than other molecular subtypes. Currently, there is increasing focus on long non-coding RNAs (lncRNAs), which can act as competing endogenous RNAs (ceR-NAs) and suppress miRNA functions involved in post-transcriptional regulatory networks in the tumor. Therefore, to investigate specific mechanisms of TNBC carcinogenesis and improve treatment efficiency, we comprehensively integrated expression profiles, including data on mRNAs, lncRNAs and miRNAs obtained from 116 TNBC tissues and 11 normal tissues from The Cancer Genome Atlas. As a result, we selected the threshold with |log2FC|>2.0 and an adjusted p-value >0.05 to obtain the differentially expressed mRNAs, miRNAs and lncRNAs. Hereafter, weighted gene co-expression network analysis was performed to identify the expression characteristics of dysregulated genes. We obtained five co-expression modules and related clinical feature. By means of correlating gene modules with protein–protein interaction network analysis that had identified 22 hub mRNAs which could as hub target genes. Eleven key dysregulated differentially expressed micro RNAs (DEmiRNAs) were identified that were significantly associated with the 22 hub potential target genes. Moreover, we found that 14 key differentially expressed lncRNAs could interact with the key DEmiRNAs. Then, the ceRNA crosstalk network of TNBC was constructed by utilizing key lncRNAs, key miRNAs, and hub mRNAs in Cytoscape software. We analyzed and described the potential characteristics of biological function and pathological roles of the TNBC ceRNA co-regulatory network; also, the survival analysis was performed for each molecule. These findings revealed that ceRNA crosstalk network could play an important role in the development and progression for TNBC. In addition, we also identified that some molecules in the ceRNA network possess clinical correlation and prognosis.
Enhanced Transmission Performance Using Backward-Propagated Broadband ASE Pump

We propose a novel first order incoherent broadband amplified spontaneous emission (ASE) pump which can be used as a seed pump in dual order backward-pumped distributed Raman amplification. Using this broadband ASE pump mitigates the relative intensity noise (RIN) transfer from the backward-propagated second order pump to the signal, and extends the reach of <inline-formula> <tex-math notation="LaTeX">$10\times120$ </tex-math></inline-formula> Gb/s DP-QPSK WDM transmission to 7915 km, giving a minimum of 12% (833 km) increase, compared with using low RIN semiconductor laser diode and random distributed feedback fiber laser.
Effect of Lattice Apron Age on the Quality of Compact Ring-Spun Yarns

Yarn manufacturing is the first stage of textile processing that converts the fibers into yarns. It is one of the subsectors of backward linkage of clothing industries [1]. The yarns can be classified on the basis of spinning techniques like ring, compact, rotor, air jet and friction [2]. Nowadays ring-spinning is mostly used because of its simplicity, flexibility and economical in commercial production [3,4]. The usages of ring spinning in about 90% of the world spinning industry make it the most popular method for short staple fiber [5]. Compact spinning attachment is trumped among various techniques not only for improvement of yarn quality but also meeting the customer’s criteria and improves subsequent processes weaving, knitting, and dying in terms of increasing productivity [6-8]. It is a fundamental modification of traditional ring spinning because it allows to condense the fiber bundle as well as to decrease the spinning triangle [9,10]. As a result, the yarns spun on the compact spinning system are characterized by higher tenacity, higher elongation-at-break [11]. Compact yarns have higher tenacity due to higher rate and amplitude of fiber migration [12]. Not only cotton yarns but also the compact spun worsted yarns also have the advantages of better quality and different surface specifications, that will help to improve further processing and increase the production rate and overall meeting the competitive advantages to survive in the market [13-17]. The hairiness of yarn significantly reduced in compact yarns as well as improvement of strength and appearance [18,19]. As it requires only some modification of traditional ring spinning, the researchers consider it as a new spinning technique because of its some revolutionary feature like superior yarn structure and quality in respect to hairiness and strength [20,21].
Effect of Toxicants on Fatty Acid Metabolism in HepG2 Cells

Impairment of hepatic fatty acid metabolism can lead to liver steatosis and injury. Testing drugs for interference with hepatic fatty acid metabolism is therefore important. To find out whether HepG2 cells are suitable for this purpose, we investigated the effect of three established fatty acid metabolism inhibitors and of three test compounds on triglyceride accumulation, palmitate metabolism, the acylcarnitine pool and dicarboxylic acid accumulation in the cell supernatant and on ApoB-100 excretion in HepG2 cells. The three established inhibitors [etomoxir, methylenecyclopropylacetic acid (MCPA), and 4-bromocrotonic acid (4-BCA)] depleted mitochondrial ATP at lower concentrations than cytotoxicity occurred, suggesting mitochondrial toxicity. They inhibited palmitate metabolism at similar or lower concentrations than ATP depletion, and 4-BCA was associated with cellular fat accumulation. They caused specific changes in the acylcarnitine pattern and etomoxir an increase of thapsic (C18 dicarboxylic) acid in the cell supernatant, and did not interfere with ApoB-100 excretion (marker of VLDL export). The three test compounds (amiodarone, tamoxifen, and the cannabinoid WIN 55,212-2) depleted the cellular ATP content at lower concentrations than cytotoxicity occurred. They all caused cellular fat accumulation and inhibited palmitate metabolism at similar or higher concentrations than ATP depletion. They suppressed medium-chain acylcarnitines in the cell supernatant and amiodarone and tamoxifen impaired thapsic acid production. Tamoxifen and WIN 55,212-2 decreased cellular ApoB-100 excretion. In conclusion, the established inhibitors of fatty acid metabolism caused the expected effects in HepG2 cells. HepG cells proved to be useful for the detection of drug-associated toxicities on hepatocellular fatty acid metabolism.
A Systematic Map of Systematic Reviews in Pediatric Dentistry—What Do We Really Know?

Objectives To identify, appraise and summarize existing knowledge and knowledge gaps in practice-relevant questions in pediatric dentistry. Methods A systematic mapping of systematic reviews was undertaken for domains considered important in daily clinical practice. The literature search covered questions in the following domains: behavior management problems/dental anxiety; caries risk assessment and caries detection including radiographic technologies; prevention and non-operative treatment of caries in primary and young permanent teeth; operative treatment of caries in primary and young permanent teeth; prevention and treatment of periodontal disease; management of tooth developmental and mineralization disturbances; prevention and treatment of oral conditions in children with chronic diseases/developmental disturbances/obesity; diagnosis, prevention and treatment of dental erosion and tooth wear; treatment of traumatic injuries in primary and young permanent teeth and cost-effectiveness of these interventions. Abstracts and full text reviews were assessed independently by two reviewers and any differences were solved by consensus. AMSTAR was used to assess the risk of bias of each included systematic review. Reviews judged as having a low or moderate risk of bias were used to formulate existing knowledge and knowledge gaps. Results Out of 81 systematic reviews meeting the inclusion criteria, 38 were judged to have a low or moderate risk of bias. Half of them concerned caries prevention. The quality of evidence was high for a caries-preventive effect of daily use of fluoride toothpaste and moderate for fissure sealing with resin-based materials. For the rest the quality of evidence for the effects of interventions was low or very low. Conclusion There is an urgent need for primary clinical research of good quality in most clinically-relevant domains in pediatric dentistry.
Assessment of carers’ psychological needs

Carers play a vital role in supporting family members who need help. Facts and figures on caregiving are set in the context of current UK policy. Research into the impact of caregiving shows that one-third to one-half of carers suffer significant psychological distress. Factors associated with carer stress are reviewed, including those related to the care-recipient, the caregiver, their relationship, and wider family and social support. The most well-known frameworks for understanding caregiving stress, including stress-process models, are introduced. Measures that may help in assessing psychological needs of carers are reviewed, emphasising the distinction between objective and subjective stress. The range of possible interventions leads to promising evidence of the effectiveness of individual psychosocial interventions, but further research is needed.
Asymmetric-access aware optimization for STT-RAM caches with process variations

STT-RAM (Spin Transfer Torque Random Access Memory) has been extensively researched as a potential replacement of SRAM (Static RAM) as on-chip caches. Prior work has shown that STT-RAM caches can improve performance and reduce power consumption because of its advantages of high density, fast read speed, low standby power, etc. However, under the impact of process variations, using worst-case design can induce significant performance and power overhead in STT-RAM caches. In order to overcome the problem of process variations, we propose to apply the variable-latency access method to STT-RAM caches by introducing a variation-aware LRU (Least Recently Used) policy. Moreover, we show that simply applying traditional variable-latency access method is inefficient due to the read/write asymmetry. First, we demonstrate that a write-oriented data migration is preferred. Second, a block remapping is necessary to prevent some cache sets from being significantly affected by process variations. After using our techniques, the experimental results show that the performance can be improved by 13.8% and power consumption can be reduced by 14.1% compared to a prior approach [3].
Neuropsychological Performance in Alcohol Dependent Patients: A One-Year Longitudinal Study

Objective Despite several studies that have highlighted the harmful effects of alcohol consumption on cognitive functions it remains unclear whether certain brain areas are more sensitive than others are or whether alcohol causes widespread cognitive deficit. Moreover, the role of continued abstinence has yet to be clarified regarding the quality of recovery on the different cognitive domains. The aim of this 1-year longitudinal study was to evaluate the recovery of cognitive deficits in the medium (6 months) and long term (12 months) after the interruption of drinking. Methods Forty-one alcohol-dependent patients were recruited from two outpatient treatment facilities and cognitive functions were compared on a control group of forty healthy controls. The patients were then re-assessed at 6 and 12 months. Changes in neuropsychological measures were evaluated with repeated measures analysis of variance (ANOVA). We also compared 1-year follow-up scores with control data (unpaired t tests) to identify tests on which significant differences persisted. Results Patients performed significantly worse than controls in all cognitive domains investigated and this cognitive impairment was evident in recently abstinent patients. A year of abstinence resulted in a significant improvement in all cognitive domains assessed after detoxification from alcohol. After year 1, alcoholic subjects had returned to normal levels compared to healthy controls on all domains except for general non-verbal intelligence, verbal memory and some visuospatial skills. Conclusion Our results support the hypothesis of widespread impairment resulting from alcohol consumption. The recovery of cognitive functions is not homogeneous during prolonged abstinence.
Impact of a COPD Discharge Care Bundle on Readmissions following Admission with Acute Exacerbation: Interrupted Time Series Analysis

Objectives We evaluated the impact of a COPD discharge care bundle on readmission rates following hospitalisation with an acute exacerbation. Design Interrupted time series analysis, comparing readmission rates for COPD exacerbations at nine trusts that introduced the bundle, to two comparison groups; (1) other NHS trusts in London and (2) all other NHS trusts in England. Care bundles were implemented at different times for different NHS trusts, ranging from October 2009 to April 2011. Setting Nine NHS acute trusts in the London, England. Participants Patients aged 45 years and older admitted to an NHS acute hospital in England for acute exacerbation of COPD. Data come from Hospital Episode Statistics, April 2002 to March 2012. Main Outcome Measures Annual trend readmission rates (and in total bed days) within 7, 28 and 90 days, before and after implementation. Results In hospitals introducing the bundle readmission rates were rising before implementation and falling afterwards (e.g. readmissions within 28 days +2.13% per annum (pa) pre and -5.32% pa post (p for difference in trends = 0.012)). Following implementation, readmission rates within 7 and 28 day were falling faster than among other trusts in London, although this was not statistically significant (e.g. readmissions within 28 days -4.6% pa vs. -3.2% pa, p = 0.44). Comparisons with a national control group were similar. Conclusions The COPD discharge care bundle appeared to be associated with a reduction in readmission rate among hospitals using it. The significance of this is unclear because of changes to background trends in London and nationally.
Histopathological evaluation of aortic coarctation after conventional balloon angioplasty in neonates

Abstract Background Optimal management strategy for native aortic coarctation in neonates and young infants is still a matter of debate. The surgical procedure, histopathologic research, and clinical outcome in 15 neonates who underwent surgery after successful balloon angioplasty is the basis of this study. Method Between 01 October, 2014 and 01 August, 2017, we enrolled 15 patients with native aortic coarctation for this study. These patients had complications regarding recoarctation, following balloon angioplasty intervention at our institute and other centres. Surgically extracted parts were examined histopathologically and patient’s data were collected retrospectively. Result The reasons for recurrence of recoarctation after balloon angioplasty are as follows: patients with higher preoperative echocardiographic gradients had recoarctation earlier, neointimal proliferation, aortic intimal fibrosis at the region of ductal insertion, and ductal residual tissue debris after balloon angioplasty. No repeat intervention was required in the 15 patients who underwent surgery followed by balloon angioplasty. Early mortality was seen in one patient after surgery. Postoperative complication in the surgical group occurred in the form of chylothorax in one patient. Conclusion In centres in which the neonatal ICU is inexperienced, balloon angioplasty is particularly recommended. In developing neonatal clinics, balloon angioplasty, when performed on patients at their earliest possible age, delays actual corrective operation to a later date, which in turn provides less risky surgical outcomes in infants who are gaining weight, growing, and do not have any haemodynamic complaints.
On Analysis of Front End Current of Rectifier Converter for low THD and high PF with SEPIC

of the power electronic equipments are operated with dc supply. For reliable and stable operation, dc supply should be regulated. The regulation can be performed using buck, boost, Cuk, Sepic, Flyback regulators. Except single phase rectifier with resistive load all other rectifiers input currents are non sinusoidal in nature. This front end current distortion of rectifier converter leads to low power factor, high THD, distribution system losses, neutral harmonic currents, over rated power equipments in a power system. Researchers have developed methods to reduce above mentioned problem. But large size and bulky filter are their drawbacks. Generally, boost converter topology is used at the output to overcome the limitation of three phase diode bridge rectifiers. But this arrangement provides only greater output voltage than input voltage. Few other topology like buck-boost, Cuk, flyback converters have been proposed to offer step up or down capability to meet the requirement. Not many studies have been reported in literature to make input current waveshaping of the rectifier converter using SEPIC. The aim of this research is to develop a Sepic regulator with improved input current quality for low THD and good power factor to ensure better efficiency for the system. In this work, a detailed study has been carried out to investigate the effect of ac to dc converter on input current that eventually injects harmonics into the power system. Various topologies of the converter with input and output passive filter arrangements have been investigated and it has been found that passive filters no longer provide optimal THD, input power factor and efficiency. Finally, a single ended primary inductor converter (SEPIC) has been proposed. The performance of the SEPIC with and without passive filter has been investigated through ORCAD simulation. It is seen that SEPIC with input passive filter provides best performances in terms of THD, input power factor and efficiency for the rectifier arrangement.