Miracle-dz/UniFAR-FTUs huggingface dataset:
Emergency Management of Increased Intracranial Pressure

Abstract Primary neurological injury in children can be induced by diverse intrinsic and extrinsic factors including brain trauma, tumors, and intracranial infections. Regardless of etiology, increased intracranial pressure (ICP) as a result of the primary injury or delays in treatment may lead to secondary (preventable) brain injury. Therefore, early diagnosis and aggressive treatment of increased ICP is vital in preventing or limiting secondary brain injury in children with a neurological insult. Present management strategies to improve survival and neurological outcome focus on reducing ICP while optimizing cerebral perfusion and meeting cerebral metabolic demands. Targeted therapies for increased ICP must be considered and implemented as early as possible during and after the initial stabilization of the child. Thus, the emergency physician has a critical role to play in early identification and treatment of increased ICP. This article intends to identify those patients at risk of intracranial hypertension and present a framework for the emergency department investigation and treatment, in keeping with contemporary guidelines. Intensive care management and the treatment of refractory increases in ICP are also outlined.
Second-Parent Adoption: North Carolina Same-Sex Couples and Foster Care Adoptions

A qualitative phenomenological study about the experiences of same-sex couples with children adopted from foster care in a southeastern U.S. state. Interview data from 8 couples were coded and analyzed. Emerging themes included legal, social, and financial struggles and the couple s trailblazing experiences to become their children s legal parents. Implications for positive social change included informing same-sex parents, policy makers and social workers about the families experiences and needs. Procedures Design • Phenomenological study Sample • Snowball sampling was used. • 8 couples were interviewed, 4 from each gender pairing. Collection • Open-ended interview protocol with 16 questions (merged Wells, 2005 & Deveny-Leggitt, 2012). Procedure • Recorded 90 minutes interviews. • Local spaces were used for the interviews. • Two interviews were conducted via Skype.
Cholesterol Accumulation Sequesters Rab9 and Disrupts Late Endosome Function in NPC1-deficient Cells*

Niemann-Pick type C disease is an autosomal recessive disorder that leads to massive accumulation of cholesterol and glycosphingolipids in late endosomes and lysosomes. To understand how cholesterol accumulation influences late endosome function, we investigated the effect of elevated cholesterol on Rab9-dependent export of mannose 6-phosphate receptors from this compartment. Endogenous Rab9 levels were elevated 1.8-fold in Niemann-Pick type C cells relative to wild type cells, and its half-life increased 1.6-fold, suggesting that Rab9 accumulation is caused by impaired protein turnover. Reduced Rab9 degradation was accompanied by stabilization on endosome membranes, as shown by a reduction in the capacity of Rab9 for guanine nucleotide dissociation inhibitor-mediated extraction from Niemann-Pick type C membranes. Cholesterol appeared to stabilize Rab9 directly, as liposomes loaded with prenylated Rab9 showed decreased extractability with increasing cholesterol content. Rab9 is likely sequestered in an inactive form on Niemann-Pick type C membranes, as cation-dependent mannose 6-phosphate receptors were missorted to the lysosome for degradation, a process that was reversed by overexpression of GFP-tagged Rab9. In addition to using primary fibroblasts isolated from Niemann-Pick type C patients, RNA interference was utilized to recapitulate the disease phenotype in cultured cells, greatly facilitating the analysis of cholesterol accumulation and late endosome function. We conclude that cholesterol contributes directly to the sequestration of Rab9 on Niemann-Pick type C cell membranes, which in turn, disrupts mannose 6-phosphate receptor trafficking.
Clevudine: a potent inhibitor of hepatitis B virus in vitro and in vivo

Clevudine (CLV) is a nucleoside analog of the unnatural L-configuration that has potent anti-hepatitis B virus (HBV) activity in vitro and in vivo with a favorable toxicity profile in all species tested. In cell culture, CLV is readily phosphorylated to the corresponding 5´-triphosphate form of the compound. The mechanism of action of CLV involves the inhibition of the HBV polymerase by CLV 5´-triphosphate. In vivo efficacy studies performed in the duck and woodchuck models showed marked, rapid inhibition of virus replication and no significant toxicity. In the woodchuck model, there was a dose-dependent delay in viral recrudescence and a reduction or loss of covalently closed circular DNA. In Phase II clinical studies, CLV was well tolerated and exhibited potent antiviral activity at all doses investigated. In Phase III studies in both hepatitis B e antigen (HBeAg)-positive and -negative patients, CLV 30 mg administered once daily demonstrated potent antiviral efficacy and significant biochemical improvement after only 24 weeks of therapy. These effects were sustained in a significant portion of the patients when therapy was stopped after 6 months with no viral rebound occurring in approximately 3 and 16% in HBeAg-positive and -negative patients, respectively. There have been no significant safety or tolerance issues associated with the drug in these studies. Future studies will investigate the safety and tolerance of CLV 30 mg given once daily over 48 weeks and longer.
The Estimated Direct Medical Cost of Selected Sexually Transmitted Infections in the United States, 2008

Background Millions of cases of sexually transmitted infections (STIs) occur in the United States each year, resulting in substantial medical costs to the nation. Previous estimates of the total direct cost of STIs are quite dated. We present updated direct medical cost estimates of STIs in the United States. Methods We assembled recent (i.e., 2002–2011) cost estimates to determine the lifetime cost per case of 8 major STIs (chlamydia, gonorrhea, hepatitis B virus, human immunodeficiency virus (HIV), human papillomavirus, genital herpes simplex virus type 2, trichomoniasis and syphilis). The total direct cost for each STI was computed as the product of the number of new or newly diagnosed cases in 2008 and the estimated discounted lifetime cost per case. All costs were adjusted to 2010 US dollars. Results Results indicated that the total lifetime direct medical cost of the 19.7 million cases of STIs that occurred among persons of all ages in 2008 in the United States was $15.6 (range, $11.0–$20.6) billion. Total costs were as follows: chlamydia ($516.7 [$258.3–$775.0] million), gonorrhea ($162.1 [$81.1–$243.2] million), hepatitis B virus ($50.7 [$41.3–$55.6] million), HIV ($12.6 [$9.5–$15.7] billion), human papillomavirus ($1.7 [$0.8–$2.9] billion), herpes simplex virus type 2 ($540.7 [$270.3–$811.0] million), syphilis ($39.3 [$19.6–$58.9] million), and trichomoniasis ($24.0 [$12.0–$36.0] million). Costs associated with HIV infection accounted for more than 81% of the total cost. Among the nonviral STIs, chlamydia was the most costly infection. Conclusions Sexually transmitted infections continue to impose a substantial cost burden on the payers of medical care in the United States. The burden of STIs would be even greater in the absence of STI prevention and control efforts.
Using curcumin to prevent structural impairments of testicles in rats induced by sodium metabisulfite

Sodium metabisulfite (Na-MBS) is a disinfectant and preservative agent. Some organ including testicle would be in danger in the case of Na-MBS consumption. Curcumin (CUR) is the constituent of turmeric with protective properties. The effect of CUR on testicles in rats exposed to Na-MBS evaluated using stereological methods. Sprague-Dawley rats were divided into eight groups. The rats in groups I to VIII received the following respectively: distilled water, CUR (100 mg/kg/day), low (0.7 mg/kg/day: acceptable daily intake), intermediate (7 mg/ kg/day), and high (70 mg/kg/day) doses of Na-MBS, and low, intermediate, and high doses of Na-MBS plus CUR. After 7 weeks, the testicles were analyzed. The volume of seminiferous tubule, tubular epithelium and tubule length reduced (25-40 %) on average in the rats that received intermediate and high doses of Na-MBS, while the connective tissue volume increased (15-20 %) in both groups (P<0.01). Besides, 19-36 % and 41-57 % of the cells (spermatogonia types A and B, spermatids, Sertoli and Leydig) were lost in the rats that received intermediate and high doses of Na-MBS respectively in comparison to the control groups. Nonetheless, all the above-mentioned alterations ameliorated drastically in the rats that received Na-MBS plus CUR compared to those exposed to Na-MBS without CUR therapy (P<0.01). The acceptable daily intake of Na-MBS for 7 weeks did not affect on testicular parameters. CUR (100 mg/kg/day) could prevent structural impairments of testicles in the rats induced by Na-MBS (7 and 70 mg/kg/day).
Prospective emotion enables episodic prospection to shift time preference

The episodic effect suggests that episodic prospection (imagining future events) can effectively reduce time discounting, the propensity to discount the value of delayed rewards relative to immediate ones. However, less clear is how episodic prospection modulates time preference. As engagement in episodic prospection usually evokes prospective emotions, it was proposed that episodic prospection might work by inducing prospective emotions. Although one previous study has attempted to provide evidence to the emotional account of the episodic effect, shortcomings in its experimental design make its conclusion questionable. In this study, we replicated previous experimental design with improvements to further test the effects of prospective emotion on time preference. By manipulating the emotional valency associated with episodic prospection in a delay discounting task, we found that positive episodic prospection attenuated time discounting; negative episodic prospection exacerbated time discounting; and episodic prospection did not shift time preference when prospective emotion is removed. These results were essentially identical to the result of the previous study. Together, these studies suggested that the effects of episodic prospection depended on prospective emotion. Thus, one cannot ignore prospective emotion if counting on episodic prospection to combat humans' impulsive behaviours.
Male and Female Risk Preferences and Maize Technology Adoption in Kenya

Risk is pervasive in developing country agriculture, and risk preferences are though to impact seed and technology choice. Empirical research on risk preferences and technology adoption typically only consider the risk preferences of a single household member. In this paper experimental techniques based on prospect theory (PT) to elicit risk aversion, loss aversion, and nonlinear probability weighting parameters from husbands and wives in Kenyan agricultural households. We also use survey data about their maize seed choice from these same respondents. We find that all three PT parameters are significant in different model specifications, and that risk preferences affect adoption differently for men and women in the same households, and also differently in the eastern and western regions of the country.
Fifteen year comparison of antipsychotic use in people with dementia within hospital and nursing home settings: sequential cross‐sectional study

The use of antipsychotics to treat people with behavioural and psychological symptoms associated with dementia is controversial, especially in long‐stay settings. We assessed the relationship between behaviour, function and antipsychotic use in people with dementia in a long‐stay psychiatric unit and designated elderly mentally ill (EMI) nursing homes over a 15‐year period.
Development of three-dimensional extended boundary-node method for potential problem

The three-dimensional boundary-node method has been reformulated without using any integration cells. For evaluation of the influence coefficients, an implicit surface is assumed as a surface boundary and the 3D polar coordinate is employed. Numerical experiments show that, for the Laplace problem, the accuracy of the proposed method is almost the same as that of the boundary-element method with linear elements.
Patient centered care: A path to better health outcomes through engagement and activation.

BACKGROUND Patient Activation and Health confidence are constructs to assess patient engagement and are utilized to encourage patient engagement. A health care provider may increase patient engagement further by utilizing behavior change theories and models such as the Trans-Theoretical Model of Change (TTM), Self-Determination Theory (SDT) and Motivational Interviewing (MI) to realize effective and lasting health behavior change by placing accountability increasingly on the patient/caregiver to choose to make changes in their health behavior on their terms. Reducing or eliminating harmful behaviors such as smoking and/or beginning or increasing beneficial health behaviors such as diet modification or performance of an exercise program, patients realize improved outcomes and better health. PURPOSE The purpose of this article is to define health confidence as a measurement tool for patient engagement, use the TTM as a measure of the patient's readiness to change, use TTM, SDT and MI as interventional approaches to effect patient change of behavior encouraged by physical therapists and incorporate the ICF as a means of identifying barriers and facilitators and incorporate the bio-psychosocial model for patient-centered care to improve health behavior, health and patient outcomes. CONCLUSION Patient-centered care requires involvement of the patient and/or their caregiver at the center of the plan. Use of the International Classification of Functioning, Disability and Health (ICF) to identify facilitators and barriers unique to the patient/caregiver offers another opportunity to successfully engage the patient by incorporating the patient's bio-psychosocial support system into care delivery and for sustainability. The ICF is a taxonomy and classification system that prompts clinicians to identify environmental factors (facilitators and barriers) that will influence the patient's ability to perform during therapy session and to sustain the interventions and employ suggestions outside of formal therapy sessions. Using the facilitators to encourage sustainable change and removing barriers, patients are more likely to realize positive health behavior change and in turn demonstrate improved outcomes and health as a result of physical therapy intervention.
Mapping client messages to a unified data model with mixture feature embedding convolutional neural network

Data mapping among different data standards in health institutes is often a necessity when data exchanges occur among different institutes. However, no matter rule-based approaches or traditional machine learning methods, none of these methods have achieved satisfactory results yet. In this work, we propose a deep learning method, mixture feature embedding convolutional neural network (MfeCNN), to convert the data mapping to a multiple classification problem. Multi-modal features were extracted from different semantic space with a medical NLP package and powerful feature embeddings were generated by MfeCNN. Classes as many as ten were classified simultaneously by a fully-connected soft-max layer based on multi-view embedding. Experimental results show that our proposed MfeCNN achieved best results than traditional state-of-the-art machine learning models and also much better results than the convolutional neural network of only using bag-of-words as inputs.
Multiple Groups of Endogenous Epsilon-Like Retroviruses Conserved across Primates

ABSTRACT Several types of cancer in fish are caused by retroviruses, including those responsible for major outbreaks of disease, such as walleye dermal sarcoma virus and salmon swim bladder sarcoma virus. These viruses form a phylogenetic group often described as the epsilonretrovirus genus. Epsilon-like retroviruses have become endogenous retroviruses (ERVs) on several occasions, integrating into germ line cells to become part of the host genome, and sections of fish and amphibian genomes are derived from epsilon-like retroviruses. However, epsilon-like ERVs have been identified in very few mammals. We have developed a pipeline to screen full genomes for ERVs, and using this pipeline, we have located over 800 endogenous epsilon-like ERV fragments in primate genomes. Genomes from 32 species of mammals and birds were screened, and epsilon-like ERV fragments were found in all primate and tree shrew genomes but no others. These viruses appear to have entered the genome of a common ancestor of Old and New World monkeys between 42 million and 65 million years ago. Based on these results, there is an ancient evolutionary relationship between epsilon-like retroviruses and primates. Clearly, these viruses had the potential to infect the ancestors of primates and were at some point a common pathogen in these hosts. Therefore, this result raises questions about the potential of epsilonretroviruses to infect humans and other primates and about the evolutionary history of these retroviruses. IMPORTANCE Epsilonretroviruses are a group of retroviruses that cause several important diseases in fish. Retroviruses have the ability to become a permanent part of the DNA of their host by entering the germ line as endogenous retroviruses (ERVs), where they lose their infectivity over time but can be recognized as retroviruses for millions of years. Very few mammals are known to have epsilon-like ERVs; however, we have identified over 800 fragments of endogenous epsilon-like ERVs in the genomes of all major groups of primates, including humans. These viruses seem to have circulated and infected primate ancestors 42 to 65 million years ago. We are now interested in how these viruses have evolved and whether they have the potential to infect modern humans or other primates.
Energy Efficient Data Collection Scheme in Mobile Wireless Sensor Networks

In wireless sensor networks, sensors typically aim to transmit their own readings to the sink node. Constructing an efficient data collection tree is very important since it can determine the lifetime of the given WSNs. In literature, may studies have investigated this issue and proposed algorithms for mobile sink to visit each sensor such that the readings of the sensors can be directly transmit to the WSN. However, visiting each sensor is time consuming which results in long path for mobile sink to pass through each sensor. Consequently, the time period between the consecutive two visits to the same sensor is long, leading to the situation of sensor buffer overflow. This paper aims to propose an efficient data collection mechanism which chooses a set of sensors to play the role of the rendezvous points (RPs) which would be visited by the mobile sink. The proposed mechanism will select important sensors as the RPs and construct an efficient path for mobile sink to collect data. Those sensors that are not visited by the mobile sink will forward their readings to the nearest RP and then the RP can relay their information to the mobile sink when it is visited. Performance results show that the proposed mechanism is better than the existing studies and significantly reduce the time period between two consecutive visits.
Family planning advice and postpartum contraceptive use among low-income women in Mexico.

CONTEXT In Mexico, family planning advice has been incorporated into the clinical guidelines for prenatal care. However, the relationship between women's receipt of family planning advice during prenatal care and subsequent contraceptive use has not been evaluated. METHODS Data were collected in 2003 and 2004 in 17 Mexican states from 2,238 urban low-income women postpartum. Participating women reported on prenatal services received and contraceptive use. Logistic and multinomial logistic regression models evaluated whether receiving family planning advice during prenatal care predicted current contraceptive use, after quality of care in the community, service utilization, delivery characteristics, household socioeconomic characteristics, and maternal and infant characteristics were controlled for. RESULTS Overall, 47% of women used a modern contraceptive method. Women who received family planning advice during prenatal care were more likely to use a contraceptive than were those who did not receive such advice (odds ratio, 2.2). Women who received family planning advice had a higher probability of using condoms (relative risk ratio, 2.3) and IUDs (5.2), and of undergoing sterilization (1.4), than of using no method. CONCLUSIONS Integrating family planning advice into prenatal care may be an important strategy for reaching women when their demand for contraception is high.
The acetylene-ethylene assay for n(2) fixation: laboratory and field evaluation.

The methodology, characteristics and application of the sensitive C(2)H(2)-C(2)H(4) assay for N(2) fixation by nitrogenase preparations and bacterial cultures in the laboratory and by legumes and free-living bacteria in situ is presented in this comprehensive report. This assay is based on the N(2)ase-catalyzed reduction of C(2)H(2) to C(2)H(4), gas chromatographic isolation of C(2)H(2) and C(2)H(4), and quantitative measurement with a H(2)-flame analyzer. As little as 1 mumumole C(2)H(4) can be detected, providing a sensitivity 10(3)-fold greater than is possible with (15)N analysis.A simple, rapid and effective procedure utilizing syringe-type assay chambers is described for the analysis of C(2)H(2)-reducing activity in the field. Applications to field samples included an evaluation of N(2) fixation by commercially grown soybeans based on over 2000 analyses made during the course of the growing season. Assay values reflected the degree of nodulation of soybean plants and indicated a calculated seasonal N(2) fixation rate of 30 to 33 kg N(2) fixed per acre, in good agreement with literature estimates based on Kjeldahl analyses. The assay was successfully applied to measurements of N(2) fixation by other symbionts and by free living soil microorganisms, and was also used to assess the effects of light and temperature on the N(2) fixing activity of soybeans. The validity of measuring N(2) fixation in terms of C(2)H(2) reduction was established through extensive comparisons of these activities using defined systems, including purified N(2)ase preparations and pure cultures of N(2)-fixing bacteria.With this assay it now becomes possible and practicable to conduct comprehensive surveys of N(2) fixation, to make detailed comparisons among different N(2)-fixing symbionts, and to rapidly evaluate the effects of cultural practices and environmental factors on N(2) fixation. The knowledge obtained through extensive application of this assay should provide the basis for efforts leading to the maximum agricultural exploitation of the N(2) fixation reaction.