Miracle-dz/UniFAR-FTUs huggingface dataset:
Postexposure prophylaxis against experimental inhalation anthrax.

Inhalation anthrax is a rare disease that is almost invariably fatal. This study determined whether a prolonged course of postexposure antibiotics with or without vaccination would protect monkeys exposed to a lethal aerosol dose of Bacillus anthracis when the antibiotic was discontinued. Beginning 1 day after exposure, groups of 10 animals were given penicillin, ciprofloxacin, doxycycline, doxycycline plus vaccination, vaccination alone, or saline. Antibiotics were administered for 30 days and then discontinued. Vaccine was given on days 1 and 15. Two animals died of causes other than anthrax and were not included in the statistical analysis. Nine of 10 controls and 8 of 10 animals given only vaccine died. Each antibiotic regimen completely protected animals while on therapy and provided significant long-term protection upon discontinuance of the drug (penicillin, 7 of 10 survived, P < .02; ciprofloxacin, 8 of 9 survived, P < .002; doxycycline, 9 of 10 survived, P < .002; doxycycline plus vaccination, 9 of 9 survived, P < .0002). Protection against rechallenge was provided by combining postexposure antibiotic treatment with vaccination.
Glia in mammalian development and disease

Glia account for more than half of the cells in the mammalian nervous system, and the past few decades have witnessed a flood of studies that detail novel functions for glia in nervous system development, plasticity and disease. Here, and in the accompanying poster, we review the origins of glia and discuss their diverse roles during development, in the adult nervous system and in the context of disease. Summary: This poster article reviews the origins of glia, their diverse roles during neural development and their contribution to plasticity and disease in the adult mammalian nervous system.
Knowledge and Explanation

Craig (1990) casts doubt upon the project of trying to give the traditional sort of necessary and sufficient conditions for A knows that p. He interprets the inadequacy of existing analyses of knowledge as evidence that our concept of knowledge is complex and diffuse, and concludes that we should aim to understand it by thinking about the rôle the concept plays in our lives, rather than by trying to find necessary and sufficient conditions for the truth of knowledge ascriptions. There is surely something right about Craig's view: we are unlikely to succeed in any attempt to analyse away the intricacies in our concept of knowledge. We cannot realistically hope to uncover a set of necessary and sufficient conditions for A knows that p which are in all cases either clearly satisfied or clearly not satisfied. Nor, I suspect, is it possible to offer necessary and sufficient conditions for knowledge which are widely accepted as being more securely understood than knowledge itself.
Unusual Spinal Dysraphic Lesions

Human tail and multiple spinal dysraphism are unusual congenital malformations. Human tail appeared as a prominent lesion from the lumbosacrococcygeal region, generally without connection between the tail and the neurospinal axis. Spinal dysraphisms are usually isolated, reaching 0.038% of incidence of multiple spinal dysraphisms in the same child. There were three cases described of unusual spinal dysraphic lesions: two cases of human tail and a case of a multiple thoracic myelomeningocele. The literature about diagnosis and treatment was reviewed. Microsurgical technique was performed to provide better exploration of the lesions, and resection could be done in those congenital malformations, without morbidity.
An empirical assessment of the loose–tight leadership model: quantitative and qualitative analyses

Summary Using questionnaire and interview data, this study attempted to find out whether the organizational loose (participative) and tight (directive) practices are compatible with or contradict each other. Using the theoretical framework of Sagie’s (1997) loose–tight leadership approach, our hypotheses concerned the effects of both practices on the employee’s work-related attitudes, and the mediating role of two variables, cognitive (information sharing) and motivational (exerting effort), in these effects. Data were analysed using two methodological approaches, quantitative and qualitative. Based on a quantitative analysis of the questionnaires given to 101 professional employees of a textile company, partial support was provided for the study hypotheses. A qualitative analysis of in-depth, semi-structured interviews with all the employees (n ¼ 20) in one of the company divisions led to similar conclusions. Specifically, we found that although the loose and tight practices affected work attitudes, the interviewees attributed more impact to the tight practice. In addition, none of the study variables mediated the loose impact on attitudes, whereas information sharing (but not exerting effort) mediated the influence of tight practice. Finally, the qualitative analysis revealed a deeper insight into the nature of both leader practices and their possible integration in the decision-making processes in organizations. Copyright # 2002 John Wiley & Sons, Ltd.
Current and Future Pharmacological Treatment Strategies in X‐Linked Adrenoleukodystrophy

Mutations in the ABCD1 gene cause the clinical spectrum of the neurometabolic disorder X‐linked adrenoleukodystrophy/adrenomyeloneuropathy (X‐ALD/AMN). Currently, the most efficient therapeutic opportunity for patients with the cerebral form of X‐ALD is hematopoietic stem cell transplantation and possibly gene therapy of autologous hematopoietic stem cells. Both treatments, however, are only accessible to a subset of X‐ALD patients, mainly because of the lack of markers that can predict the onset of cerebral demyelination. Moreover, for female or male X‐ALD patients with AMN, currently only unsatisfying therapeutic opportunities are available. Thus, this review focuses on current and urgently needed future pharmacological therapies. The treatment of adrenal and gonadal insufficiency is well established, whereas applications of immunomodulatory and immunosuppressive drugs have failed to prevent progression of cerebral neuroinflammation. The use of Lorenzo's oil and the inefficacy of lovastatin to normalize very‐long‐chain fatty acids in clinical trials as well as currently experimental and therefore possible future therapeutic strategies are reviewed. The latter include pharmacological gene therapy mediated by targeted upregulation of ABCD2, the closest homolog of ABCD1, antioxidative drug treatment, small molecule histone deacetylase inhibitors such as butyrates and valproic acid, and other neuroprotective attempts.
Angiotensin-(1–7) in the Rostral Ventrolateral Medulla Modulates Enhanced Cardiac Sympathetic Afferent Reflex and Sympathetic Activation in Renovascular Hypertensive Rats

Enhancement of the cardiac sympathetic afferent reflex (CSAR) contributes to sympathetic excitation in hypertension. The aim of the present study was to determine whether angiotensin (Ang)-(1–7) in the rostral ventrolateral medulla (RVLM) modulated the enhanced CSAR and sympathetic activation, and the signaling pathways that mediated these effects in the 2-kidney, 1-clip renovascular hypertension model. Cardiac sympathetic afferent reflex was evaluated using renal sympathetic nerve activity and mean arterial pressure responses to epicardial capsaicin application in anesthetized sinoaortic-denervated and cervical-vagotomized rats. RVLM microinjection of Ang-(1–7) induced greater increases in renal sympathetic nerve activity and mean arterial pressure, and greater enhancement in CSAR in 2-kidney, 1-clip rats than in sham-operated rats, which was blocked by Mas receptor antagonist A-779, adenylyl cyclase inhibitors SQ22536 and MDL-12,330A, and protein kinase A inhibitors rp-adenosine-3′,5′-cyclic monophosphorothionate and H-89. Mas receptor expression in RVLM was increased in 2-kidney, 1-clip rats. Treatment with A-779, SQ22536, MDL-12,330A, rp-adenosine-3′,5′-cyclic monophosphorothionate, or H-89 in RVLM inhibited CSAR and decreased renal sympathetic nerve activity and mean arterial pressure in 2-kidney, 1-clip rats, whereas cAMP analogue dibutyryl-cAMP had the opposite effects. Ang-(1–7) in RVLM increased, whereas A-779 decreased the cAMP level and the epicardial capsaicin application-induced increases in the cAMP level in RVLM. These results indicate that Ang-(1–7) in the RVLM enhances the CSAR and increases the sympathetic outflow and blood pressure via Mas receptor activation. The increased endogenous Ang-(1–7) and Mas receptor activity in RVLM contributes to the enhanced CSAR and sympathetic activation in renovascular hypertension, and the cAMP-protein kinase A pathway is involved in these Ang-(1–7)–mediated effects in the RVLM.
Bone density at interradicular sites: implications for orthodontic mini-implant placement.

OBJECTIVES Implant stability is primarily related to local bone density; Few studies have evaluated interradicular bone density related to mini-implant placement for orthodontic anchorage. Therefore, this study evaluated bone density differences between interradicular sites. SETTING AND SAMPLE POPULATION Computed tomographic (CT) images were obtained from 14 males and 14 females (mean age 27 years, range 23-35 years). Bone density in Hounsfield units (HU) was measured at 13 interradicular sites and four bone levels. RESULTS Bone densities in most areas were higher than 850 HU. Statistically significant differences in bone density were detected at different levels and sites. Bone densities in both maxilla and mandible significantly increased from the alveolar crest toward basal bone in posterior areas, while the opposite was observed in anterior areas. There were statistically significant differences in bone densities between the maxilla and mandible in posterior areas. Bone densities progressively increased from anterior to posterior areas in the mandible. CONCLUSION The results suggest that mini-implants for orthodontic anchorage may be effective when placed in most areas with equivalent bone density up to 6 mm apical to the alveolar crest. Site selection should be adjusted according to bone density assessment.
Features of the Selectivity for Contrast Polarity in Contour Integration Revealed by a Novel Tilt Illusion

We studied a novel illusion of tilt inside checkerboards due to the role of contrast polarity in contour integration. The preference for binding of oriented contours having same contrast polarity, over binding of opposite polarity ones (CP rule), has been used to explain several visual illusions. In three experiments we investigated how the binding effect is influenced by luminance contrast value, relatability of contour elements, and distance among them. Experiment 1 showed that the effect was indeed present only when the CP rule was satisfied, and found it to be stronger when the luminance contrast values of the elements are more similar. In experiment 2 the illusion was reported only with relatable edges, and its strength was modulated by the degree of relatability. The CP-rule effectiveness, thus, seems to depend on good continuation. The intensity of contrast polarity signals propagating from an oriented contour might be the less intense, the more its direction deviates from linearity. In experiment 3 we estimated the distance threshold and found it to be smaller than the one found for other illusions, arising with collinear fragments. This seems to show that the reach of the contrast polarity signal inside the association field of a contour unit is shorter along non-collinear orientations than along collinear ones.
How Viktor Yanukovych Won

This article explores two prominent narratives through an analysis of election data. The first narrative is that Yanukovych’s win was legitimate. While fraud may have been present, its scale was small and it was not decisive. The second narrative suggests that Ukraine’s major operational political cleavage separates eastern and western regions, rendering the central region of the country a crucial prize for candidates to secure victory in presidential contests.
THE TEACHER AS RESEARCHER: ACTION RESEARCH STUDIES ON CREATIVITY AND PLAY

How can we help teachers connect theory and practice? How can we help them to incorporate play and creativity into their early childhood classrooms? How can they adjust to administrators who emphasize academics in a climate of standards-based instruction? How can we show teachers that their classrooms can be exciting arenas for child-centered, collaborative learning with respect for varying developmental differences? I teach a graduate class, Creativity and Play in Early Childhood, for early childhood teachers. To prove to my students that they can weave play and creative experiences into their early childhood classroom settings, I require that they implement a qualitative ministudy (or "change project") within their classrooms. They identify a general area of interest within several broad categories, and decide what they wish to change or add to their classroom. Each study is unique and is shaped by their particular setting, teaching style, goals for their students, and curricular constraints. Studies have included: eliminating the teacher's desk to make room for a child-centered art area; assembling prop boxes containing articles donated by families to create thematic creative dramatic play areas; and changing the "10-min break" into a "20-min free play break" in a second grade classroom that previously had no free play. Students are required to write a research paper and present their results in a 30-min presentation to the class. They are also required to keep a journal during the semester. For most of the students, this is the first time they have engaged in qualitative research.
Facilitating developer-user interactions with mobile app review digests

As users are interacting with a large of mobile apps under various usage contexts, user involvements in an app design process has become a critical issue. Despite this fact, existing apps or app store platforms only provide a limited form of user involvements such as posting app reviews and sending email reports. While building a unified platform for facilitating user involvements with various apps is our ultimate goal, we present our preliminary work on handling developers' information overload attributed to a large number of app comments. To address this issue, we first perform a simple content analysis on app reviews from the developer's standpoint. We then propose an algorithm that automatically identifies informative reviews reflecting user involvements. The preliminary evaluation results document the efficiency of our algorithm.
Myelodysplastic syndrome with isolated deletion of chromosome 20q: an indolent disease with minimal morphological dysplasia and frequent thrombocytopenic presentation

The present study analysed the clinicopathological features of nine myelodysplastic syndrome (MDS) patients in which del(20q) was the sole cytogenetic abnormality and a control group of 17 adult patients with idiopathic thrombocytopenic purpura (ITP). Seven of nine del(20q) patients were thrombocytopenic and six of nine were mildly anaemic at presentation. There was no significant morphological dysplasia identified in the del(20q) group as compared with the ITP group. These results indicate that MDS with del(20q) commonly presents with thrombocytopenia and has minimal morphological dysplasia. Cytogenetic analysis on adult patients undergoing bone marrow sampling for thrombocytopenia may help avoid misdiagnosis of MDS with del(20q) as ITP.
Volunteer Motivations and Constraints Among College Students

This research examined motivational factors of college students to volunteer in various capacities using the Volunteer Function Inventory. Volunteering characteristics, scope of volunteerism, volunteer segments, and type of contributions were investigated. In addition, constraints to participation based on the leisure constraint model were explored. Data were collected at a major university in the southeast United States. Results identified that the majority were involved in volunteerism in some capacity. Organizations that focused on human services were the most important type of organizations to volunteers. Families and teachers were responsible for introducing almost the majority to volunteerism. Also, more than half reported time as their most important contribution. The strongest motives were related to the values and understanding dimension which reflected helping others and expanding one’s own perspective on an issue. Structural constraints were most likely to limit volunteerism. Several associations between motivations and constraints were further examined and discussed.
Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth

Cancer tissues are composed of cancer cells and the surrounding stromal cells (e.g., fibroblasts, vascular endothelial cells, and immune cells), in addition to the extracellular matrix. Most studies investigating carcinogenesis and the progression, invasion, metastasis, and angiogenesis of cancer have focused on alterations in cancer cells, including genetic and epigenetic changes. Recently, interactions between cancer cells and the stroma have attracted considerable attention, and increasing evidence has accumulated on this. Several researchers have gradually clarified the origins, features, and roles of cancer-associated fibroblasts (CAFs), a major component of the cancer stroma. CAFs function in a similar manner to myofibroblasts during wound healing. We previously reported the relationship between CAFs and angiogenesis. Interleukin-6 (IL-6), a multifunctional cytokine, plays a central role in regulating inflammatory and immune responses, and important roles in the progression, including proliferation, migration, and angiogenesis, of several cancers. We showed that CAFs are an important IL-6 source and that anti-IL-6 receptor antibody suppressed angiogenesis and inhibited tumor-stroma interactions. Furthermore, CAFs contribute to drug-resistance acquisition in cancer cells. The interaction between cancer cells and the stroma could be a potential target for anti-cancer therapy.
Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell Types

Type I interferons (IFN-I) were identified over 50 years ago as cytokines critical for host defense against viral infections. IFN-I promote anti-viral defense through two main mechanisms. First, IFN-I directly reinforce or induce de novo in potentially all cells the expression of effector molecules of intrinsic anti-viral immunity. Second, IFN-I orchestrate innate and adaptive anti-viral immunity. However, IFN-I responses can be deleterious for the host in a number of circumstances, including secondary bacterial or fungal infections, several autoimmune diseases, and, paradoxically, certain chronic viral infections. We will review the proposed nature of protective versus deleterious IFN-I responses in selected diseases. Emphasis will be put on the potentially deleterious functions of IFN-I in human immunodeficiency virus type 1 (HIV-1) infection, and on the respective roles of IFN-I and IFN-III in promoting resolution of hepatitis C virus (HCV) infection. We will then discuss how the balance between beneficial versus deleterious IFN-I responses is modulated by several key parameters including (i) the subtypes and dose of IFN-I produced, (ii) the cell types affected by IFN-I, and (iii) the source and timing of IFN-I production. Finally, we will speculate how integration of this knowledge combined with advanced biochemical manipulation of the activity of the cytokines should allow designing innovative immunotherapeutic treatments in patients. Specifically, we will discuss how induction or blockade of specific IFN-I responses in targeted cell types could promote the beneficial functions of IFN-I and/or dampen their deleterious effects, in a manner adapted to each disease.
Electronic Commerce, Automation and Online Banking in Nigeria: Challenges and Benefits

Electronic banking has been around for some time in the form of automatic teller machines and telephone transactions. More recently, it has been metamorphosed by the Internet with a new look and delivery channel for banking services that benefits both customers and banks. The objective of this paper is to find out the correlation between the anticipated benefits/challenges and encountered benefits/challenges. This paper empirically adopted the use of survey research to explore in quantitative terms the various challenges and benefits e-business poses to Nigerian businesses, with particular reference to Banking and Finance Industry. It was found out that there is a statistically significant difference between the anticipated and encountered benefits and major challenges in the potential security breaches faced by the customers. Constant training of employees both local and international on new development in online trading should be encouraged.
Envolvimento religioso e fatores sociodemográficos: resultados de um levantamento nacional no Brasil

CONTEXTO: As relacoes entre envolvimento religioso e saude tem sido objeto de crescente interesse, mas ha carencia de estudos fora dos Estados Unidos e da Europa. OBJETIVOS: O presente estudo descreve o envolvimento religioso na populacao brasileira e sua relacao com variaveis sociodemograficas. METODOS: Numa amostra probabilistica da populacao brasileira (n = 3.007), variaveis sociodemograficas e de envolvimento religioso foram avaliadas. RESULTADOS: Cinco por cento dos brasileiros declararam nao ter religiao, 83% consideraram religiao muito importante para sua vida e 37% frequentavam um servico religioso pelo menos uma vez por semana. As filiacoes religiosas mais frequentes foram Catolicismo (68%), Protestante/Evangelica (23%) e Espiritismo Kardecista (2,5%). Dez por cento referiram frequentar mais de uma religiao. De modo semelhante a estudos em outros paises, maior idade e sexo feminino se associaram a maiores niveis de religiosidade subjetiva e organizacional, mesmo apos o controle para outras variaveis sociodemograficas. Entretanto, nivel educacional, renda e raca negra nao se associaram de modo independente a indicadores de religiosidade. CONCLUSAO: Este estudo mostra altos niveis de religiosidade entre os brasileiros e sugere que religiosidade, em diferentes culturas, pode relacionar-se de modo diferente com outras variaveis. Para uma melhor compreensao da influencia da religiosidade na saude, e necessario expandir esse tipo de estudo para outras culturas.