Miracle-dz/UniFAR-FTUs huggingface dataset:
Mobility Viewer: An Eulerian Approach for Studying Urban Crowd Flow

Studying human movement citywide is important for understanding mobility and transportation patterns. Rather than investigating the trajectories of individuals, we employ an Eulerian approach to analyze the crowd flows among a geographical network and a social network, which are extracted from mobile phone data. We design a suite of visualization techniques to illustrate the dynamic evolutions of the flow over the networks. We contribute the design and implementation of a visual analytics system, which is called Mobility Viewer, that supports situation-aware understanding and visual reasoning of human mobility. We exemplify our approach with a real citywide data set of seven million users in two months.
Exchange of genetic markers at extremely high temperatures in the archaeon Sulfolobus acidocaldarius

When cells of two auxotrophic mutants of Sulfolobus acidocaldarius are mixed and incubated on solid medium, they form stable genetic recombinants which can be selected, enumerated, and characterized. Any of a variety of auxotrophic markers can recombine with each other, and the phenomenon has been observed at temperatures of up to 84 degrees C. The ability to exchange and recombine chromosomal markers appears to be an intrinsic property of S. acidocaldarius strains. It occurs between two cell lines derived from the same parent or from different parents and also between a recombinant and its parent. This is the first observation of chromosomal marker exchange in archaea from geothermal environments and provides the first functional evidence of generalized, homologous recombination at such high temperatures.
A New Architecture of Online Trading Platform Based on Cloud Computing

Along with the development of grid computing and cloud computing, finite computing resources supplied by stand-alone server usually become the bottleneck in the process of system implementation of online trading platform. Moreover, It is difficult to reuse algorithm module and the system also becomes more complicated to achieve. Traditional online trading framework can not preferably solve the problem listed above. Thus, we propose a framework of online trading platform based on cloud computing. It is feasible to establish a high-complexity online trading platform using infinite virtual computing capability provided by cloud computing. Simultaneously, this framework can realize the sharing of data sets after the integration of heterogeneous and distributed data based on layered thoughtway, and supply theoretical foundation and framework support for setting up a unified, open, distributed, and parallel online trading platform.
Interventional therapy of malignant obstructive jaundice.

OBJECTIVE To assess the short-term results of interventional therapy for malignant obstructive jaundice. METHODS In 82 patients with malignant obstructive jaundice, hepatocellular carcinoma was detected in 10 patients, carcinoma of gallbladder in 14, hilar biliary carcinoma in 22, pancreatic carcinoma in 20, and hilar metastatic carcinoma in 16. Percutaneous transhepatic biliary internal and/or external drainage (PTBIED) was performed in 61 patients and percutaneous transhepatic insertion of biliary stent (PTIBS) in 21. RESULTS The level of total serum bilirubin (TSB) was reduced in 71 patients and less markedly in others. The level of TSB of the 61 patients was reduced from 450.12+/-113.51 micromol/L before operation to 240.25+/-107.81 micromol/L and 90.91+/-101.72 micromol/L 1 and 2 weeks after operation respectively. The TSB level of the 21 patients was reduced from 410.53+/-98.13 micromol/L to 270.23+/-115.64 micromol/L and 105.43+/-97.85 micromol/L 1 and 2 weeks after operation, respectively. No significant difference was found in the effect between PTBIED and PTIBS. Short-term complications developed in 33 patients. Seven patients died 30 days after operation. CONCLUSION Interventional therapy may be simple, safe and effective in the treatment of malignant obstructive jaundice.
Spinal rigidity following acute myelitis

A patient with a 2½‐year history of painful spasms and rigidity of both lower limbs is described. Symptoms began after an episode of acute myelitis. The spasms—which were spontaneous and stimulus sensitive and occurred on voluntary action—involved the repetitive grouped discharge of motor units. Continuous motor unit activity was present at rest in the muscles of both legs, and cutaneomuscular reflexes were abnormal. This patient is similar to those recently reported as having stiffness and spasms of the legs due to a possible chronic spinal interneuronitis and provides further evidence that this kind of movement disorder may be caused by spinal cord pathology.
River flow regimes in a changing climate

Abstract A river flow regime describes an average seasonal behaviour of flow and reflects the climatic and physiographic conditions in a basin. Differences in the regularity (stability) of the seasonal patterns reflect different dimensionality of the flow regimes, which can change subject to changes in climate conditions. The empirical orthogonal functions (EOF) approach can be used to describe the intrinsic dimension of river flow regimes and is also an adopted method for reducing the phase space in connection to climate change studies, especially in studies of nonlinear dynamic systems with preferred states. A large data set of monthly river flow for the Nordic countries has been investigated in the phase space reduced to the first few amplitude functions to trace a possible signature of climate change on the seasonal flow patterns. The probability density functions (PDF) of the weight coefficients and their possible change over time were used as an indicator of climate change. Two preferred states were identified connected to stable snowmelt-fed and rainfed flow regimes. The results indicate changes in the PDF patterns with time towards higher frequencies of rainfed regime types. The dynamics of seasonal patterns studied in terms of PDF renders it an adequate and convenient characterization, helping to avoid bias connected to flow regime classifications as well as uncertainties inferred by a modelling approach.
A novel temperature-insensitive optical fiber pressure sensor for harsh environments

A novel diaphragm-based miniature optical fiber pressure sensor has been shown to work at temperatures up to 700/spl deg/C with a sensitivity of 2.93 nm/psi and a resolution of 0.01 psi (68.9 Pa). A passive temperature compensation scheme was used to reduce the temperature dependence to 0.0076 psi//spl deg/C (52.4 Pa//spl deg/C). The sensor exhibited a linear response in the available testing range from 0 to 200 psi (1.38 MPa), and being composed entirely of fused silica, the sensor's structure is very reliable, corrosion resistant, and immune to electromagnetic interference.
Précis of Images of Mind

Abstract This volume explores how functional brain imaging techniques like positron emission tomography have influenced cognitive studies. The first chapter outlines efforts to relate human thought and cognition in terms of great books from the late 1800s through the present. Chapter 2 describes mental operations as they are measured in cognitive science studies. It develops a framework for relating mental operations to activity in nerve cells. In Chapter 3, the PET method is reviewed and studies are presented that use PET to map the striate cortex and to activate extrastriate motion, color, and form areas. Chapter 4 shows how top down processes involving attention can lead to activation of these same areas in the detection of targets, visual search, and visual imagery. This chapter reveals complex networks of activations. Chapters 5 and 6 deal with the presentation of words. Chapter 5 illustrates PET studies of the anatomy of visual word processing and shows how the circuitry used for generating novel uses of words changes as the task becomes automated. Chapter 6 applies high density electrical recording to explore these activations in real time and to show how a constant anatomy can be reprogrammed by task instructions to produce and perform different cognitive tasks. Chapter 7 shows how studies of brain lesions and PET converge on common networks underlying attentional functions such as visual orienting, target detection, and maintenance of the alert state. Chapters 8 and 9 apply the network approach to examine normal development of attention in infants and pathological conditions resulting from brain damage, and psychiatric pathologies of depression, schizophrenia, and attention deficit disorder. In Chapter 10, new developments such as functional MRI are discussed in terms of future developments and integration of cognitive neuroscience.
Absolute myocardial perfusion in canines measured by using dual-bolus first-pass MR imaging.

PURPOSE To compare fluorescent microsphere measurements of myocardial blood flow (MBF) with qualitative, semiquantitative, and fully quantitative measurements of first-pass perfusion at magnetic resonance (MR) imaging. MATERIALS AND METHODS Coronary artery occlusion or intracoronary adenosine infusion was successfully performed in 16 beagles; both procedures were performed simultaneously in one animal. MBF was assessed at microsphere analysis. First-pass myocardial perfusion MR imaging was performed during a dual-bolus administration of gadopentetate dimeglumine (0.0025 mmol/kg followed by 0.10 mmol/kg). The absolute myocardial perfusion at MR imaging was calculated by using Fermi function deconvolution methods. Qualitative, semiquantitative, and absolute myocardial perfusion MR imaging measurements were compared with microsphere MBF measurements by using paired t tests, linear correlation, and Bland-Altman analysis. RESULTS Fully quantitative (ie, absolute) analysis of MBF at MR imaging correlated with microsphere MBF measurement (r = 0.95, P <.001) across the full range of blood flow rates encountered (from 0 to >5.0 mL/min/g). Similar close correlations were observed in endocardial and epicardial segments (representing approximately 0.85 g of the myocardium). With modest increases in MBF, qualitative measurements plateaued in the hyperemic zones. Semiquantitative measurements did not correlate with MBF as well (r = 0.69-0.89); they plateaued around 3.0 mL/min/g. CONCLUSION Dual-bolus MR imaging enabled accurate measurement of absolute epicardial and endocardial perfusion across a wide range of blood flow rates (0 to >5.0 mL/min/g). Use of qualitative MR imaging measures such as the contrast enhancement ratio led to substantially underestimated hyperemic blood flow measurements.
Analysis of G1/S checkpoint regulators in metastatic melanoma

We have analyzed the expression of the CDKN1A (p21CIP1), CDKN1B (p27Kip1), TP53, RB1 and MDM2 proteins and tumor cell proliferation by immunohistochemical staining in 59 cases of metastatic melanoma. The genomic status of the CDKN2A (INK4‐ARF, p16/p14ARF), CDKN2B (p15) and CDKN2C (p18) genes was determined by PCR‐SSCP (single‐strand conformation polymorphism) in 46 of these cases. These results were correlated with various clinico‐pathological parameters, including the outcome of combined chemoimmunotherapy. We found positive correlations between the expression of CDKN1A and MDM2 (r = 0.5063, P = 0.001), between the expression of CDKN1B and RB1 (r = 0.5026, P = 0.001), and between RB1 expression and tumor cell proliferation (0.5564, P < 0.001). Two mutations in the CDKN2A (p16) gene were detected, including a novel base change AAC→ATC (Asn to Ile) at codon 71, that also changes the codon 85 of the alternative reading frame gene p14ARF from CAA to CAT (Gln to His). Homozygous deletion at exon 2 of the CDKN2A (INK4‐ARF) gene was detected in six cases. In seven cases, the 540C→G polymorphism in the 3′UTR of the CDKN2A (p16) gene was found in linkage disequilibrium with the 74C→A polymorphism in intron 1 of the CDKN2B gene (P < 0.0001). These cases had significantly lower expression of the TP53 protein (P = 0.0032). Both 540C→G and 580C→T polymorphisms in the 3′UTR of the CDKN2A (p16) gene were associated with significantly shorter progression time from primary to metastatic disease (P = 0.0071). We conclude, that although none of the analyzed cell cycle regulators could be singled out as a major prognostic factor, G1/S checkpoint abnormalities remain one of the most significant factors in the development of malignant melanoma. Genes Chromosomes Cancer 28:404–414, 2000. © 2000 Wiley‐Liss, Inc.
Uncertainty Management Intervention for Older African American and Caucasian Long-Term Breast Cancer Survivors

Abstract The survivor uncertainty management intervention study is a randomized controlled study designed to test the efficacy of an intervention that combines training in audiotaped cognitive behavioral strategies to manage uncertainty about cancer recurrence with a self-help manual designed to help women understand and manage long-term treatment side effects and other symptoms. Specifically, women were taught to recognize their own personal triggers of uncertainty (places, events or surroundings, that bring back memories, feelings, or concerns about breast cancer), and then use coping skills such as relaxation, distraction, and calming self-talk to deal with uncertainty. Also, women were taught to use the manual as a resource for dealing with fatigue, lymphedema, pain and other symptoms. Treatment outcome data (Mishel et al., in press) indicated that the uncertainty management intervention resulted in improvements in cognitive reframing, cancer knowledge, social support, knowledge of symptoms and side effects, and coping skills when compared to a control condition. The purpose of the present paper was to report on the use and helpfulness of the intervention components by the 244 women who were in the intervention. Findings indicated that women regularly used the intervention components to deal with triggers of breast cancer recurrence and long-term treatment side effects and most women found the strategies very helpful.
Recognition of emotional‐prosodic meanings in speech by autistic, schizophrenic, and normal children

The abilities of autistic, schizophrenic, and normal‐control children to label four emotional intonations (the emotional task) in speech were tested, along with a linguistic task. All stimuli were pretested on normal adults. Older (≥ 8 years of age) normal children performed as well as adults on both tasks; younger normal children and both younger and older autistic children performed poorly on the emotional task; children (all older) diagnosed as schizophrenic were not significantly impaired in either task. Mental age was not correlated with performance in autistic children. The relevance of these results to other findings regarding emotional and linguistic behaviors in normal and disabled children is considered.
Robust H2/H8 control of nonlinear system with differential uncertainty

Differential uncertainty is involved in actual system inevitably. That brings great inconvenience for the controller design. In this paper we treat the differential uncertainty as a separate item, and use the robust control theory to analyze the robust performance. Considering the impact of parameter variations, un-model dynamics and external disturbances, we design robust H2/H∞ controller. We use the ship yaw/roll coupling system to verify the effectiveness of the controller. We present a simulation result which shows that the robust H2/H∞ controller designed in this paper has good robust stability and can meet the system required performance.
Casting doubt on the traditional approach of cancer biomarker discovery through proteomics

Towards revolutionary biomarkers, a considerable amount of research funds and time have been dedicated to proteomics. Although the discovery of novel biomarkers at the dawn of proteomics was a promising development, only a few identified biomarkers seemed to be beneficial for cancer patients. We may need to approach this issue differently, instead of only extending the conventional approaches that have been used historically. The study of biomarkers is essentially a study of diseases and the biochemistry relating to peptide, protein and post-translational modifications is only a tool. A problem-oriented approach should be needed in biomarker development. Clinician participation in the study of biomarkers will lead to realistic, practical and interesting biomarker candidates, which justify the time and expense involved in validation studies. Although discussion in this article is focused on cancer biomarkers, it can generally be applied to biomarker studies for other diseases.
Random Walk with Restart over Dynamic Graphs

Random Walk with Restart (RWR) is an appealing measure of proximity between nodes based on graph structures. Since real graphs are often large and subject to minor changes, it is prohibitively expensive to recompute proximities from scratch. Previous methods use LU decomposition and degree reordering heuristics, entailing O(|V|3) time and O(|V|2) memory to compute all (|V|2) pairs of node proximities in a static graph. In this paper, a dynamic scheme to assess RWR proximities is proposed: (1) For unit update, we characterize the changes to all-pairs proximities as the outer product of two vectors. We notice that the multiplication of an RWR matrix and its transition matrix, unlike traditional matrix multiplications, is commutative. This can greatly reduce the computation of all-pairs proximities from O(|V|3) to O(|Δ|) time for each update without loss of accuracy, where |Δ| (
Imparting Self-Control Skills to Decrease Aggressive Behavior in a 12-Year-Old Boy

•Summary: This paper presents the case of a 12-year-old boy with oppositional defiant disorder (ODD) who demonstrated no interest in participating in therapy. The aims of the paper were to present a multiple therapy design as an effective measurement for social workers to use in their regular intervention process; to learn about the relative effectiveness of three common methods for addressing ODD (behavior therapy being used in teacher supervision and parental counseling and cognitive therapy being used in the child’s individual therapy); and to present a self-control model for improving the child’s behavior. •Findings: The case study pointed to the efficacy of the self-control model for helping the child change. Therapy facilitated a significant decrease in the child’s disruptive behavior as well as a significant increase in the child’s self-control and social interaction. Also, the case study presented the feasibility of the single case design as an effective way for social workers to assess and evaluate their intervention. •Applications: The presented case study highlighted the ability of social workers: 1. to supervise parents and teachers as important change agents in the child’s environment; 2. to use the single case design in daily intervention; and 3. to utilize cognitive behavioral therapy as an effective method for change. The efficacy of the intervention pinpointed the need to apply the proposed methods for other problems as well.
VDMs for finding and re-finding web search results

This paper presents Visual Data Mountains (VDMs), a tool intended to assist users to find relevant documents and discover varied topics among Web search results. The interface is also intended to improve how users re-find search results. A small-scale pilot study was conducted to evaluate the enjoyment of VDMs and its perceived effectiveness for finding and re-finding tasks on the Web.
Eating disorders and emotional neglect: a case report -

Eating disorders and emotional neglect: a case report Eating disorders are psychiatric disorders presenting various problems in eating behavior and have biological, psychological, social factors as important causes. Personality features and traumatic experiences have significant role in its development. Psychiatric comorbidity and trauma history are frequently seen among eating disorder patients and are important matters affecting prognosis and treatment course. Trauma history is more frequently encountered among bulimic patients than in non-bulimic patients. Although initial studies about trauma have focused on sexual abuse, later studies have demonstrated that trauma spectrum in eating disorders range from sexual abuse to physical and emotional abuse, neglect and indifference. In this case report, a young female patient diagnosed with anorexia nervosa (binge eating/ purging) that psychological factors and traumatic experiences have significant role in its development, is presented.
Lessons from the medical and surgical ICU.

As the field of neurologic intensive care has become better defined and more independent from medical and surgical intensive care, there has been a trend to focus on the neurologic aspects of care. This approach has allowed many of the recent advances in neurocritical care, including research into hemicraniectomy for malignant stroke syndromes and cooling for brain injury. As we continue to improve our therapies to protect brain function and augment recovery, it is increasingly important to look at the advances in medical and surgical critical care to evaluate both the new therapies that they test and the processes employed to study fundamental issues. This review discusses three trends in research and care in medical and surgical intensive care units (ICUs) that may impact the care of patients in the neurointensive care unit (neuroICU). Although many of the studies behind these trends are important landmarks in critical care, it is important to note that they were conducted in patients with illnesses and injuries that are distinct from what is normally seen in the neurointensive care setting. These results may not be applicable in different ICU settings. As a specialty, we need to validate these promising studies in our patient population before we fully endorse a change in standard of care. For now, they serve as examples of current thinking on research into the problems of critically injured patients.
Organisational culture and cloud computing: coping with a disruptive innovation

Since 2007, cloud computing has emerged as a computing paradigm that is likely to change many of the traditional ways of delivering computing services to people and organisations. Many organisations, small and large, have embraced it because of the advantages it promises in terms of flexible cost structure, scalability and efficiency. However, is cloud computing the type of disruptive innovation that is likely to require a fundamental shift in the way supplying organisations view their delivery of computing services, and in the way consuming organisations perceive and use those services? This paper attempts to address this issue by reflecting on the developments of this emerging computing service modality and Christensen's theory of disruptive innovation. In doing so, the article highlights the implications of cloud computing for the future directions of organisations and their cultures.
Novel Techniques to Suppress the Common-Mode EMI Noise Caused by Transformer Parasitic Capacitances in DC–DC Converters

This paper proposes novel electromagnetic interference (EMI) suppression techniques for dc-dc converters. For low-voltage high-current applications, windings are paralleled and interleaved. Although low conduction loss and low leakage inductance can be achieved, the winding capacitances are considerably increased, thereby deteriorating the converter's EMI and soft-switching performances. To solve these problems, a novel balanced choke concept is proposed, as well as other techniques. The advantages of the proposed concepts and strategies are verified and demonstrated on a 1-kW 1-MHz 400-V/12-V LLC resonant converter prototype. More than 52-dB noise attenuation and 75% equivalent winding capacitance reduction are achieved. Hence, EMI and soft-switching performances are significantly improved.