Miracle-dz/UniFAR-FTUs huggingface dataset:
A fluorescence in situ hybridization‐based screen allows rapid detection of adverse cytogenetic alterations in patients with acute myeloid leukemia

In adult acute myeloid leukemia (AML), the karyotype of the leukemic cell is among the strongest prognostic factors. The Medical Research Council (MRC) and the European LeukemiaNet (ELN) classifications distinguish between favorable, intermediate and adverse cytogenetic risk patients who differ in their treatment response and overall survival. Conventional cytogenetic analyses are a mandatory component of AML diagnostics but they are time‐consuming; therefore, therapeutic decisions in elderly patients are often delayed. We investigated whether a screening approach using a panel of seven fluorescence in situ hybridization (FISH) probes would allow rapid identification of adverse chromosomal changes. In a cohort of 334 AML patients, our targeted FISH screening approach identified 80% of adverse risk AML patients with a specificity of 99%. Incorporating FISH screening into diagnostic workup has the potential to accelerate risk stratification and treatment selection, particularly in older patients. This approach may allow therapeutic decisions more quickly, which benefits both patients and physicians and might save costs.
EmotionAir: Perception of Emotions from Air Jet Based Tactile Stimulation

Several studies in affective computing consider the role of haptic channel via the tactile and kinesthetic components. However, these works used constraining haptic devices with limited stimulation strategies. This paper proposes to investigate a new haptic device for the tactile stimulation with a mobile air jet. This approach is more suitable for the stimulation of skin mechanoreceptors which play an important role in social and affective behaviors. An experimental study was conducted in order to understand the relationships between the physical features of the air jet and the perception of emotions by participants. The results highlight a main effect of the intensity and movement velocity of the air jet stimulation on the evaluations of valence, arousal, and dominance.
M-band biorthogonal interpolating wavelets via lifting scheme

Recently, the lifting scheme was generalized to the multidimensional and multiband cases and was used to design M-band interpolating scaling filters and their duals. Based on this idea, we develop a new lifting pattern, namely, the progressive lifting pattern. This pattern allows us to pairwise generate M-band interpolating filterbanks and wavelets by the order from lowpass to highpass filters. A complete lifting procedure is divided into M - 1 simple steps, in each step, a pair of filters (the l'th filter and its dual) are generated. In this way, an M -band biorthogonal interpolating filterbank/wavelet is determined by M(M - 1) lifting filters. The first 2(M 1) lifting filters completely characterize the two scaling filters as well as the vanishing moments of bandpass and highpass filters; the residual (M - 1) (M - 2) lifting filters are used to pairwise optimize the bandpass and highpass filters in terms of the criterion of stopband energy minimization. The obtained M-band biorthogonal interpolating filterbanks and wavelets provide excellent frequency characteristics, in particular, low stopband sidelobes. Furthermore, the pattern is also utilized to design signal-adapted interpolating filterbanks and their rational coefficient counterparts in terms of subband coding gain. The obtained filterbanks achieve large subband coding gains. The rational coefficient filterbanks preserve the biorthogonality and allow wavelet transforms from integers to integers and a unifying lossy/lossless coding framework at the cost of a slight degradation in subband coding gain.
Leakage flow reduction in different configuration of labyrinth seal on a turbine blade tip

This paper contains experimental and numerical investigation of the leakage flow over the blade tip in turbine stage. Experiments were conducted in non-rotating linear channel. Test rig was intended to model the geometry of the labyrinth seal of the blades of the lower pressure turbine stage. Investigated model contained two different geometries of labyrinth fins. Moreover smooth and honeycomb stator landing were tested. Experimental measurements have been supported by CFD simulation which gives valuable information of flow structure in labyrinth seal and show complex flow physics in the investigated model.
The Use of Telemedicine in Obstetrics: A Review of the Literature

Telemedicine has been advertised for increasing efficiency, extending the scope of obstetric practice, improving pregnancy outcomes, and reducing costs in the healthcare system. The extent of telemedicine use in obstetrics was identified with a literature search. A total of 268 articles were identified of which 60 are the basis for this review. Telemedicine has been used to read ultrasounds, interpret nonstress tests, counsel patients, manage diabetes, manage postpartum depression, and support parents and children postpartum from remote sites. Reductions in time lost from work, transportation costs, more efficiency for the health care providers, and reducing medical costs all have been suggested as benefits of telemedicine. Despite the information published about telemedicine in obstetrics, this technology has not been shown to have adverse effects in obstetrics but neither has it demonstrated unequivocal benefits. Properly structured and powered investigations will be needed to determine the role of telemedicine in the future. Target Audience: Obstetricians & Gynecologists Learning Objectives: After completing this CME activity, physicians should be better able to diagnose and treat diabetes using telemedicine techniques; assess the current scope of research in telemedicine in obstetrics; implement clinical telemedicine consultations based on the interaction and the needs of the participants; and the opportunities for further research in telemedicine in obstetrics.
Strains across the Acetabular Labrum during Hip Motion

Background Labral tears commonly cause disabling intra-articular hip pain and are commonly treated with hip arthroscopy. However, the function and role of the labrum are still unclear. Hypotheses (1) Flexion, adduction, and internal rotation (a position clinically defined as the position for physical examination known as the impingement test) places greatest circumferential strain on the anterolateral labrum and posterior labrum; (2) extension with external rotation (a position clinically utilized during physical examination to assess for posterior impingement and for anterior instability) places significant circumferential strains on the anterior labrum; (3) abduction with external rotation during neutral flexion-extension (the position the extremity rests in when a patient lies supine) places the greatest load on the lateral labrum. Study Design Descriptive laboratory study. Methods Twelve cadaveric hips (age, 79 years) without labral tears or arthritis were studied. Hips were dissected free of soft tissues, except the capsuloligamentous structures. Differential variable reluctance transducers were placed in the labrum anteriorly, anterolaterally, laterally, and posteriorly to record circumferential strains in all 4 regions as the hip was placed in 36 different positions. Results The posterior labrum had the greatest circumferential strains identified; the peak was in the flexed position, in adduction or neutral abduction-adduction. The greatest strains anteriorly were in flexion with adduction. The greatest strains anterolaterally were in full extension. External rotation had greater strains than neutral rotation and internal rotation. The greatest strains laterally were at 90° of flexion with abduction, and external or neutral rotation. In the impingement position, the anterolateral strain increased the most, while the posterior labrum showed decreased strain (greatest magnitude of strain change). When the hip is externally rotated and in neutral flexion-extension or fully extended, the posterior labrum has significantly increased strain, while the anterolateral labrum strain is decreased. Conclusion These are the first comprehensive strain data (of circumferential strain) analyzing the whole hip labrum. For the intact labrum, the greatest strain change was at the posterior acetabulum, whereas clinically, acetabular labral tears occur most frequently anterolaterally or anteriorly. The results are consistent with the impingement test as an assessment of anterolateral acetabular labral stress. The hyperextension-rotation test, often used clinically to assess anterior hip instability and posterior impingement, did not show a change in strain anteriorly, but did reveal an increase in strain posteriorly. Clinical Relevance Although this study does not include muscular forces across the hip joint, it does provide a clue as to the stresses about the labrum through the complete range of motions of the hip, which may help in providing a better understanding of the cause of labral tears and in the protection of labral repairs.
3D Point Cloud Registration Based on the Vector Field Representation

This paper introduces an automatic coarse-to-fine registration method using an implicit volumetric Vector Field representation for 3D point clouds. Highly discriminative correspondence detection for coarse alignment can be extracted by a process such as cascade-filters. In the cascade-filter approach, a number of interest points is first reduced by using curvature signs and connected component labeling to segment a view into convex and concave disjoint regions. The prominent points are selected for each region based on estimated Mean curvature values of each local segmentation. A new point similarity descriptor is then computed for these selected points to select the best ones for final matching. This multidimensional descriptor is a combination of information from a Darboux frame defined by the principal directions and normal vector at the point, and local Mean curvatures of neigbours. A pose refinement process without closest point search is then applied to the rough pose estimation. Both registration processes are supported entirely and uniquely by the Vector Field representation. The reliability of our approach has been validated on multiple real datasets.
Short‐stay thyroid surgery

Traditionally, patients are observed for up to 72 h after thyroid surgery to guard against the potentially fatal complications of airway compromise, haemorrhage and severe hypocalcaemia. However, 75 per cent of lifethreatening complications occur within 6 h of operation, and the remainder are seen between 7 and 24 h1. Previous authors have reported successful series of short-stay and day-case thyroid surgery with no increase in complication or mortality rates2–4. An operation followed by observation in hospital for up to 23 h constitutes ‘same day’ surgery in North America. This paper describes the introduction of short-stay thyroid surgery in a district general hospital in the UK.
Acute Heart Failure Syndromes: Current State and Framework for Future Research

Acute heart failure syndromes (AHFS) poses unique diagnostic and management challenges. This syndrome has recently received attention from researchers, clinicians, regulatory agencies, and the pharmaceutical industry. However, there is no consensus on its definition, epidemiology, pathophysiology, appropriate therapeutic options, and directions for future research. This document is the result of the First and Second International Workshop on Acute Heart Failure Syndrome that took place in May 2004 and April 2005. At these workshops, a selected group of physician scientists, epidemiologists, clinicians, regulatory and governmental funding agencies, and industry representatives from North and South America and Europe convened to develop a platform for future investigative approaches and management of AHFS. Subsequently, emergency physicians, who play a pivotal role in the early management of AHFS, contributed to this document. AHFS is defined as gradual or rapid change in heart failure (HF) signs and symptoms resulting in a need for urgent therapy. These symptoms are primarily the result of severe pulmonary congestion due to elevated left ventricular (LV) filling pressures (with or without low cardiac output). AHFS can occur in patients with preserved or reduced ejection fraction (EF). Concurrent cardiovascular conditions such as coronary heart disease (CHD), hypertension, valvular heart disease, atrial arrhythmias, and/or noncardiac conditions (including renal dysfunction, diabetes, anemia) are often present and may precipitate or contribute to the pathophysiology of this syndrome.1–3 HF hospitalizations have risen steadily, with >1 million in 2004 in the United States4; a similar number has been reported in Europe. In the United States, it is estimated that these hospitalizations account for >75% of the 46 billion dollars spent each year on the care of HF patients.4 Although much has been accomplished in the management of chronic HF, the absence of evidence-based clinical practice guidelines for AHFS is striking in comparison to …
Energy-Efficient Adaptive Transmission Scheme in a Correlated Wireless Sensor Network

In this paper, we develop an adaptive transmission scheme in a wireless sensor network (WSN). Distributed sensors can cooperate with the neighborhood and transmit their data to the data collector by choosing a proper transmission mode adaptively based on the channel conditions and spatial correlation among the sensors. By investigating the statistical properties of a correlated virtual multiple-input multiple-output (MIMO) channel between the sensors and data collector, we assess the analytic performances of two different MIMO transmission modes -- spatial multiplexing and transmit diversity achieving schemes. We also evaluate energy efficiencies of two MIMO transmission modes. Based on these result, we derive a new energy efficient mode switching criterion between spatial multiplexing and transmit diversity suitable to a WSN.
The Role Concept in Data Models

A new data model is described which permits the representation of the different roles which a real world entity may play. This data model is an extension of the network model, as used in I-D-S and its derivative, the CODASYL database system. The concepts of item and set are retained. The record concept has been refined to clarify the old record concept and introduce the new role-segment concept. The record represents the existence of an entity of the real world while the role-segment represents the existence of one of the entity's roles. A person and a corporation are examples of an entity, while a stockholder and a customer are examples of a role that either the person or corporation can assume. A role-segment occurrence serves to group and name the properties concerning the existence of one role. This paper shows that the record and role segment concepts can be integrated into the required data description and data manipulation language. The meta entity types of the role data model are contrasted with those of older data models for the data occurrence domain. The ambigous use of meta types by the older models is thus shown. This ambiguity appears to prohibit those older data models from serving as the basis of a conceptual schema where data transformation support of richer data models is required. The meta entity types of the role data model are identified, described and related to the real world, data occurrence, conceptual schema, and data description domains.
Insulator‐based dielectrophoresis of microorganisms: Theoretical and experimental results

Dielectrophoresis (DEP) is the motion of particles due to polarization effects in nonuniform electric fields. DEP has great potential for handling cells and is a non‐destructive phenomenon. It has been utilized for different cell analysis, from viability assessments to concentration enrichment and separation. Insulator‐based DEP (iDEP) provides an attractive alternative to conventional electrode‐based systems; in iDEP, insulating structures are used to generate nonuniform electric fields, resulting in simpler and more robust devices. Despite the rapid development of iDEP microdevices for applications with cells, the fundamentals behind the dielectrophoretic behavior of cells has not been fully elucidated. Understanding the theory behind iDEP is necessary to continue the progress in this field. This work presents the manipulation and separation of bacterial and yeast cells with iDEP. A computational model in COMSOL Multiphysics was employed to predict the effect of direct current‐iDEP on cells suspended in a microchannel containing an array of insulating structures. The model allowed predicting particle behavior, pathlines and the regions where dielectrophoretic immobilization should occur. Experimental work was performed at the same operating conditions employed with the model and results were compared, obtaining good agreement. This is the first report on the mathematical modeling of the dielectrophoretic response of yeast and bacterial cells in a DC‐iDEP microdevice.
Implementing electronic medical records in a psychiatric hospital: A qualitative study

Abstract The objective of this study is to examine health care professionals' opinions of the critical events (opportunities and barriers) surrounding EMR implementation in a French teaching psychiatric hospital. This qualitative study was based on semi-structured interviews with 115 health care professionals: 16 psychiatrists, 84 nurses, six psychologists or social assistants and nine secretaries or administrative professionals. Interviews were thematically analysed. Most responders (96%) used EMR. Among these EMR users, 70% perceived EMR positively. Concerning the opportunities from implementing an EMR, the most represented theme was “the improved access to medical record information” (75%), followed by “the strategy to guarantee the adhesion of professionals and the use of EMR” (69%), and “the technological performances of EMR” (49%). Concerning the barriers to implementation, four themes emerged, as follows: “the workflow and efficiency decrease” (73%), “the triangulation of the patient-professional relationship” (47%), “the information sharing and confidentiality” (32%), and “the ambiguity of EMR” (26%), which answers both to the production of care and to an economic issue. In conclusion, EMR implementation involved several critical components, and the strategy of implementation is particularly important. Implementing an EMR should be considered a continuous process, and the principle and theory of continuous quality improvement appears pertinent for addressing this problem.
Direct methods for 3D reconstruction and visual SLAM

The reconstruction of the 3D world from camera images has a tradition of over 100 years. Nevertheless, we have witnessed over the last few years a dramatic boost in performance of reconstruction algorithms. An important innovation underlying this performance boost is the development of direct methods to estimate the 3D structure and the camera motion. Some of these developments shall be reviewed in the following.
The Genome Sequence of the SARS-Associated Coronavirus

We sequenced the 29,751-base genome of the severe acute respiratory syndrome (SARS)–associated coronavirus known as the Tor2 isolate. The genome sequence reveals that this coronavirus is only moderately related to other known coronaviruses, including two human coronaviruses, HCoV-OC43 and HCoV-229E. Phylogenetic analysis of the predicted viral proteins indicates that the virus does not closely resemble any of the three previously known groups of coronaviruses. The genome sequence will aid in the diagnosis of SARS virus infection in humans and potential animal hosts (using polymerase chain reaction and immunological tests), in the development of antivirals (including neutralizing antibodies), and in the identification of putative epitopes for vaccine development.
Stratospheric water vapor feedback

Significance We show observational evidence for a stratospheric water vapor feedback—a warmer climate increases stratospheric water vapor, and because stratospheric water vapor is itself a greenhouse gas, this leads to further warming. An estimate of its magnitude from a climate model yields a value of +0.3 W/(m2⋅K), suggesting that this feedback plays an important role in our climate system. We show here that stratospheric water vapor variations play an important role in the evolution of our climate. This comes from analysis of observations showing that stratospheric water vapor increases with tropospheric temperature, implying the existence of a stratospheric water vapor feedback. We estimate the strength of this feedback in a chemistry–climate model to be +0.3 W/(m2⋅K), which would be a significant contributor to the overall climate sensitivity. One-third of this feedback comes from increases in water vapor entering the stratosphere through the tropical tropopause layer, with the rest coming from increases in water vapor entering through the extratropical tropopause.
Eosinophil-derived neurotoxin levels at 3 months post-respiratory syncytial virus bronchiolitis are a predictive biomarker of recurrent wheezing

Abstract Objective: To determine whether eosinophil-derived neurotoxin (EDN) is a predictive marker of recurrent wheezing episodes in post-respiratory syncytial virus (RSV) bronchiolitis. Methods: EDN levels and recurrent wheezing episodes were serially measured in 200 infants hospitalized with RSV bronchiolitis. Results: Serum EDN levels at 3 months correlated significantly with total wheezing episodes at 12 months in the RSV-PLC (n = 71; r = 0.720, p < 0.0001) and RSV-MONT groups (n = 79; r = 0.531, p < 0.001). Positive predictive value of 3-mo EDN level for total wheezing episodes was 57%; negative predictive value, 76%; sensitivity, 72%; specificity, 62%. Conclusion: EDN levels have predictive value for the development of recurrent wheezing post-RSV bronchiolitis.
How to find frequent patterns

An improved version of DF, the depth-first implementation of Apriori, is presented. Given a database of (e.g., supermarket) transactions, the DF algorithm builds a so-called trie that contains all frequent itemsets, i.e., all itemsets that are contained in at least `minsup' transactions with `minsup' a given threshold value. In the trie, there is a one-to-one correspondence between the paths and the frequent itemsets. The new version, called DF+, differs from DF in that its data structure representing the database is borrowed from the FP-growth algorithm. So it combines the compact FP-growth data structure with the efficient trie-building method in DF.
Fundamental Initial Frequency and Frequency Rate Estimation of Random-Amplitude Harmonic Chirps

We consider the problem of estimating the fundamental initial frequency and frequency rate of a linear chirp with random amplitudes harmonic components. We develop an iterative nonlinear least squares estimator, which involves a large number of computations as it requires high resolution search in the initial frequency and frequency rate parameter space. As an alternative, we suggest two suboptimal low-complexity estimators. The first is based on the high-order ambiguity function, which reduces the problem to a one-dimensional search. The second method applies our recently published harmonic separate-estimate method, which was used for constant-amplitude harmonic chirps. We present modifications of both methods for harmonic chirps with random amplitudes. We also provide a framework for estimating the number of harmonic components. Numerical simulations show that the iterative nonlinear least-squares estimator achieves its asymptotic accuracy in medium to high signal-to-noise ratio, while the two sub-optimal low-complexity estimators perform well in high signal-to-noise ratio. Real data examples demonstrate the performance of the harmonic separate-estimate method on random amplitude real-life signals.