Miracle-dz/UniFAR-FTUs huggingface dataset:
40,000 memories in young teenagers: Psychometric properties of the Autobiographical Memory Test in a UK cohort study

Although the Autobiographical Memory Test (AMT) is widely used its psychometric properties have rarely been investigated. This paper utilises data gathered from a 10-item written version of the AMT, completed by 5792 adolescents participating in the Avon Longitudinal Study of Parents and Children, to examine the psychometric properties of the measure. The results show that the scale derived from responses to the AMT operates well over a wide range of scores, consistent with the aim of deriving a continuous measure of over-general memory. There was strong evidence of group differences in terms of gender, low negative mood, and IQ, and these were in agreement when comparing an item response theory (IRT) approach with that based on a sum score. One advantage of the IRT model is the ability to assess and consequently allow for differential item functioning. This additional analysis showed evidence of response bias for both gender and mood, resulting in attenuation in the mean differences in AMT across these groups. Implications of the findings for the use of the AMT measure in different samples are discussed.
MSH2/MSH6 Complex Promotes Error-Free Repair of AID-Induced dU:G Mispairs as well as Error-Prone Hypermutation of A:T Sites

Mismatch repair of AID-generated dU:G mispairs is critical for class switch recombination (CSR) and somatic hypermutation (SHM) in B cells. The generation of a previously unavailable Msh2−/−Msh6−/− mouse has for the first time allowed us to examine the impact of the complete loss of MutSα on lymphomagenesis, CSR and SHM. The onset of T cell lymphomas and the survival of Msh2−/−Msh6−/− and Msh2−/−Msh6−/−Msh3−/− mice are indistinguishable from Msh2−/− mice, suggesting that MSH2 plays the critical role in protecting T cells from malignant transformation, presumably because it is essential for the formation of stable MutSα heterodimers that maintain genomic stability. The similar defects on switching in Msh2−/−, Msh2−/−Msh6−/− and Msh2−/−Msh6−/−Msh3−/− mice confirm that MutSα but not MutSβ plays an important role in CSR. Analysis of SHM in Msh2−/−Msh6−/− mice not only confirmed the error-prone role of MutSα in the generation of strand biased mutations at A:T bases, but also revealed an error-free role of MutSα when repairing some of the dU:G mispairs generated by AID on both DNA strands. We propose a model for the role of MutSα at the immunoglobulin locus where the local balance of error-free and error-prone repair has an impact in the spectrum of mutations introduced during Phase 2 of SHM.
A low-power multi-tanh OTA with very low harmonic distortion

This paper presents a wide input range, low-power operational transconductance amplifier (OTA) in weak inversion. The OTA is implemented with tanh-triplets differential pairs, degenerated by a composite configuration to augment the input linear range, thus reducing further the harmonic distortion. Using MATLAB, the mismatch factor (A) of a typical multi-tanh triplet has been optimised for minimum harmonic distortion. The OTA is designed in UMC 0.13um CMOS technology with 1.2V supply. Simulations show that the input range can be extended to 300 mV, while keeping the HD3 below -80 dB. The average power consumption is 13nW, with an open loop-gain of 76 dB and a unity gain frequency of 250 Hz. The low harmonic distortion OTA can find potential applications in low-power and long time constant filters.
RESPONSABILIDAD Y COMPORTAMIENTO ANTISOCIAL DEL ADOLESCENTE COMO FACTORES ASOCIADOS AL RENDIMIENTO ESCOLAR

The academic success of teenagers is related to the time that they devote to studying, which in turn is determined by their level of responsibility as well as for their record of troublesome behavior. Thus, this study aims at examining the relationship between school performance, antisocial behavior and level of responsibility in a sample of 433 teenagers from Asturia (Spain) who attended different public educational centers. With this purpose three assessment instruments were used: A questionnaire that gathers information about school performance; a personality questionnaire (Big-Five) and an inventory for antisocial behavior (ICA). Findings showed that the adolescents' self-informed antisocial behavior and the individual variable of responsibility affect both the school adjustment of our teenagers as well as their interest to devote their time to school learning. The study analyzes the implications of these findings and shows some guidelines for f uture research in this field
Les nouveaux acteurs locaux de la sécurité publique en Belgique

Sous les termes de « nouveaux acteurs locaux de la securite publique», on formalise aujourd’hui une plethore de petits metiers du controle social local au statut precaire et a la definition incertaine. En general, ces intervenants se surajoutent aux acteurs policiers et leurs missions sont definies en negatif de celles exercees par ces professionnels. Pourtant, sous des dehors de constante experimentation, ce type de dispositif prend en Belgique une place de plus en plus importante, non seulement dans le cadre des politiques dites de prevention de la delinquance, mais egalement dans l’exercice d’une fonction policiere locale. Au travers de l’examen des « assistants de prevention et de securite», cette contribution vise a exposer le glissement vers ceux-ci de modalites d’exercice de cette fonction policiere et a repondre a la question de la complementarite entre anciens et nouveaux uniformes.
Marginal Confinement in Tokamaks by Inductive Electric Field

Here diffusion and Ware pinch are analyzed as opposed effects for plasma confinement, when instabilities are not considered. In this work it is studied the equilibrium inductive electric field where both effects annul each other in the sense that the average normal velocity is zero, that is, marginal velocity confinement is reached. The critical electric field defined in that way is studied for different values of elliptic elongation, Shafranov shift and triangularity. A short complementary analysis is also performed of the variation of the poloidal magnetic field along a magnetic line. Magnetohydrodynamic transport theory in the collisional regime is used as in recent publications. Axisymmetric and up-down symmetry are assumed
Packing messages as a tool for boosting the performance of total ordering protocols

This paper compares the throughput and latency of four protocols that provide total ordering. Two of these protocols are measured with and without message packing. We used a technique that buffers application messages for a short period of time before sending them, so more messages are packed together. The main conclusion of this comparison is that message packing influences the performance of total ordering protocols under high load overwhelmingly more than any other optimization that was checked in this paper, both in terms of throughput and latency. This improved performance is attributed to the fact that packing messages reduces the header overhead for messages, the contention on the network, and the load on the receiving CPUs.
Students' Motivational Goals and their Perceptions about Teachers' Motivational Practices at University Level

The present study explored the relationship between research students’ motivational goals and their perceptions about motivational practices of teachers. The inculcation of research oriented thinking in research students is a concern of utmost importance. Goals and Perceptions about Teaching Practices Scale (GPTPS) was used to elicit responses from 181 out of 640 students of Master in Education (1 st semester) enrolled in Institute of Education and Research (IER), University of the Punjab, Lahore, Pakistan. A pilot study was conducted to ensure the reliability of the instrument (α = .93). Correlation between motivational goals and motivational practices was calculated through Pearson. Analysis of Variance (ANOVA) was run to see difference in achievement goal orientations on the basis of demographic variables. Multivariate Analysis of Variance (MANOVA) was run to see difference in achievement goal orientations of different programs. Results showed a strong correlation between teaching practices of teachers and performance goal orientation of students studying at IER. It is, therefore, recommended that teachers should change their motivational practices in order to promote learning oriented goals in students in the subject of research.
Polish Forum for Prevention Guidelines on Prophylactic Pharmacotherapy: update 2017.

1Department of Cardiac and Vascular Diseases, Institute of Cardiology, Jagiellonian University Medical College at John Paul II Hospital, Krakow, Poland 21st Department of Cardiology, Medical University of Warsaw, Warsaw, Poland 3Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland 4Chair of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland 5Centre for Family and Community Medicine, Faculty of Health Sciences, Medical University of Lodz, Lodz, Poland 6Department of Epidemiology, CVD Prevention, and Health Promotion, Institute of Cardiology, Warsaw, Poland 7Department of Preventive Medicine and Medical Education, Medical University in Gdansk, Gdansk, Poland 81st Department of Cardiology, Interventional Electrocardiology and Hypertension, Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland 9Department of Haemodynamics and Angiocardiography, John Paul II Hospital, Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland 10Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland 11Department of Pharmacogenomics, Division of Biochemistry and Clinical Chemistry, Medical University of Warsaw, Warsaw, Poland 122nd Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland 13Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland 14Department of Paediatric Cardiology and Rheumatology, Medical University of Lodz, Lodz, Poland 15Department of Family Medicine, Jagiellonian University Medical College, Krakow, Poland 16Department of Internal Diseases and Rural Medicine, Jagiellonian University Medical College, Krakow, Poland
Update on Stomatal Signaling Networks Calcium-Dependent and-Independent Stomatal Signaling Network and Compensatory Feedback Control of Stomatal Opening via Ca 2 + Sensitivity Priming [ W ]

Institute of Technology, University of Tartu, Tartu 50411, Estonia (K.L., E.M., H.K.); Division of Biological Sciences, Cell and Developmental Biology Section, University of California, San Diego, La Jolla, California 92093–0116 (B.B., J.L., J.I.S.); College of Forest Resources and Environment, Nanjing Forestry University, Nanjing 210037, China (J.L.); Institute of Plant Physiology and Ecology, Shanghai Institute for Biological Sciences, The Chinese Academy of Sciences, Shanghai 200032, China (Y.-F.W.); and Department of Pharmacology, School of Medicine, Howard Hughes Medical Institute, University of California, San Diego, La Jolla, California 92093–0654 (M.M.K., S.S.T.)
Output trajectory tracking for a switched nonlinear non-minimum phase system: The VSTOL aircraft

This work concerns output trajectory tracking for the McDonnell Dougglas YAV68B Harrier VSTOL aircraft. This system can perform three distinct flight modes, and is modelled with a Lagrangian nonlinear hybrid non-minimum phase dynamics. Output tracking is solved using classical input/output linearization scheme associated to an internal dynamics stable inversion for each flight mode dynamics. The performance of the global switched control law is discussed and validated through simulation tests.
Developing Theory to Guide Building Practitioners’ Capacity to Implement Evidence-Based Interventions

Public health and other community-based practitioners have access to a growing number of evidence-based interventions (EBIs), and yet EBIs continue to be underused. One reason for this underuse is that practitioners often lack the capacity (knowledge, skills, and motivation) to select, adapt, and implement EBIs. Training, technical assistance, and other capacity-building strategies can be effective at increasing EBI adoption and implementation. However, little is known about how to design capacity-building strategies or tailor them to differences in capacity required across varying EBIs and practice contexts. To address this need, we conducted a scoping study of frameworks and theories detailing variations in EBIs or practice contexts and how to tailor capacity-building to address those variations. Using an iterative process, we consolidated constructs and propositions across 24 frameworks and developed a beginning theory to describe salient variations in EBIs (complexity and uncertainty) and practice contexts (decision-making structure, general capacity to innovate, resource and values fit with EBI, and unity vs. polarization of stakeholder support). The theory also includes propositions for tailoring capacity-building strategies to address salient variations. To have wide-reaching and lasting impact, the dissemination of EBIs needs to be coupled with strategies that build practitioners’ capacity to adopt and implement a variety of EBIs across diverse practice contexts.
Measurement of total polycyclic aromatic hydrocarbon concentrations in sediments and toxic units used for estimating risk to benthic invertebrates at manufactured gas plant sites

The U.S. Environmental Protection Agency's (U.S. EPA) narcosis model requires the measurement of 18 parent and 16 groups of alkyl polycyclic aromatic hydrocarbons (PAHs) (so‐called 34 PAHs) in sediments to calculate the number of PAH toxic units (TU) available to benthic organisms. If data for the 34 PAHs are not available, the U.S. EPA proposes estimating the risk by multiplying the TU for 13 parent PAHs by 11.5 (95% confidence interval) based on data from 488 sediments. This estimate is overly conservative for PAHs from pyrogenic manufactured gas plant (MGP) processes based on the analysis of 45 sediments from six sites. Parent PAHs contributed approximately 40% of the total concentrations and TU for MGP sediments. In contrast, parent PAHs from diesel fuel and petroleum crude oil contributed only 2 and 1%, respectively, of the PAH concentrations and TU, compared to approximately 98 to 99% contributed by the alkyl PAHs. Statistical comparison of the TU based on the measured 34 alkyl and parent PAHs and those based on only 13 parent PAHs demonstrated that a factor of 4.2 (rather than 11.5) is sufficient to estimate total TU within a 95% confidence level for MGP sites. Similarly, measurement of parent PAHs is sufficient to accurately estimate the total 34 alkyl and parent PAH concentrations for MGP‐impacted sediments.
US Geographic Distribution of rt-PA Utilization by Hospital for Acute Ischemic Stroke

Background and Purpose— Previously, we have estimated US national rates of recombinant tissue plasminogen activator (rt-PA) use to be 1.8% to 3.0% of all ischemic stroke patients. However, we hypothesized that the rate of rt-PA use may vary widely depending on regional variation, and that a large percentage of the US population likely does not have access to hospitals using rt-PA regularly. We describe the US geographic distribution of hospitals using rt-PA for acute ischemic stroke. Method— This analysis used the MEDPAR database, which is a claims-based dataset that contains every fee-for-service Medicare-eligible hospital discharge in the US. Cases potentially eligible for rt-PA treatment based on diagnosis were defined as those with a hospital DRG code of 14, 15, or 559, and that also had an ICD-9 code of 433, 434, or 436. Thrombolysis use was defined as an ICD-9 code of 99.1. Study interval was July 1, 2005 to June 30, 2007. Hospital locations were mapped using ArcView software; population densities and regions of the US are based on US Census 2000. Results— There were 4750 hospitals in the MEDPAR database, which included 495 186 ischemic stroke admissions during the study period. Of these hospitals, 64% had no reported treatments with rt-PA for ischemic stroke, and 0.9% reported >10% treatment rates within the MEDPAR dataset. Bed size, rural or underserved designation, and population density were significantly associated with reported rt-PA treatment rates, and remained significant in the multivariable regression. Approximately 162 million US citizens reside in counties containing a hospital reporting a ≥2.4% treatment rate within the MEDPAR dataset. Conclusion— We report the first description of US hospital rt-PA treatment rates by hospital. Unfortunately, we found that 64% of US hospitals did not report giving rt-PA at all within the MEDPAR database within a 2-year period. These tended to be hospitals that were smaller (average bed size of 95), located in less densely populated areas, or located in the South or Midwest. In addition, 40% of the US population resides in counties without a hospital that administered rt-PA to at least 2.4% of ischemic stroke patients, although distinguishing transferred patients is problematic within administrative datasets. Such national-based resource-utilization data is important for planning at the local and national level, especially for such initiatives as telemedicine, to reach underserved areas.
The metabolic fate of zoxazolamine (flexin) in man.

A major pathway for the metabolism in man of the muscle relaxant and uricosuric drug, zoxazolamine, is via hydroxylation in the benzene ring to form 6-hydroxy-zoxazolamine which is excreted in urine as a glucuronide. Evidence is also presented for the excretion in urine of small amounts of a product (chlorzoxazone) formed by the substitution of the amino group of zoxazolamine for a hydroxyl group. 6-Hydroxy-zoxazolamine has little or no muscle relaxant properties whereas chlorzoxazone has muscle relaxant properties similar to those of zoxazolamine. Neither 6-hydroxy-zoxazolamine nor chlorzoxazone possesses uricosuric activity in gouty subjects. The in vitro metabolism of zoxazolamine by TPN fortified liver homogenates has been described. It was found that the administration of 3,4-benzpyrene to rats markedly stimulates the activity of the enzyme system in liver which metabolizes zoxazolamine.
On Family and Fear: A Gendered Perspective on the Design of Identity Technologies

Identity technologies constitute the means by which we include or exclude individuals and groups in terms of access to goods, services or information and yet few developments in this space explicitly recognise the relevance of gender in identity design. In this paper, we describe some design insights from working with a group of women refugees. This work is part of a larger research project that adopts an inclusive design philosophy, where we have been working with marginalised communities that include older adults, teenagers not in employment or education (NEETs) and the disabled. Our overall goal is to allow these marginalised communities a voice in driving identity design forward, but in this position paper we reflect on some of the issues raised by the women refugees and ask more generally whether we should reasonably consider women as a marginalised group.
Metabolic Engineering in Nicotiana benthamiana Reveals Key Enzyme Functions in Arabidopsis Indole Glucosinolate Modification[W]

Chemical modifications such as hydroxylations or methylations can alter the ecological significance of plant secondary metabolites. This work shows that members from two gene families, CYP81Fs and IGMTs, are responsible for such modifications of indole glucosinolates in Arabidopsis. Indole glucosinolates, derived from the amino acid Trp, are plant secondary metabolites that mediate numerous biological interactions between cruciferous plants and their natural enemies, such as herbivorous insects, pathogens, and other pests. While the genes and enzymes involved in the Arabidopsis thaliana core biosynthetic pathway, leading to indol-3-yl-methyl glucosinolate (I3M), have been identified and characterized, the genes and gene products responsible for modification reactions of the indole ring are largely unknown. Here, we combine the analysis of Arabidopsis mutant lines with a bioengineering approach to clarify which genes are involved in the remaining biosynthetic steps in indole glucosinolate modification. We engineered the indole glucosinolate biosynthesis pathway into Nicotiana benthamiana, showing that it is possible to produce indole glucosinolates in a noncruciferous plant. Building upon this setup, we demonstrate that all members of a small gene subfamily of cytochrome P450 monooxygenases, CYP81Fs, are capable of carrying out hydroxylation reactions of the glucosinolate indole ring, leading from I3M to 4-hydroxy-indol-3-yl-methyl and/or 1-hydroxy-indol-3-yl-methyl glucosinolate intermediates, and that these hydroxy intermediates are converted to 4-methoxy-indol-3-yl-methyl and 1-methoxy-indol-3-yl-methyl glucosinolates by either of two family 2 O-methyltransferases, termed indole glucosinolate methyltransferase 1 (IGMT1) and IGMT2.
Cohesión social, democracia, participación social y lazo societal

La nocion de cohesion social implica una definicion de sociedad moderna como una sociedad fundamentada sobre un sentido de comunidad y responsabilidad entre sus miembros. En este sentido, tal concepcion enfatiza en la participacion en los asuntos publicos, en el mercado de trabajo, en la vida comunitaria y en un sentimiento de pertenencia, todos factores que incrementarian la solidaridad y la confianza entre los miembros de una sociedad. Nos proponemos discutir tanto estas ideas como sus implicaciones para las minorias etnicas y nacionales en Canada. Tratamos de demostrar como el concepto de cohesion social resulta insuficiente en la definicion de democratizacion, capital social y pertenencia a una sociedad. Ademas, evidenciamos su omision de la reproduccion estructural de desigualdades, su negacion en la legitimizacion de las protestas que tienen por objetivo un cambio en las relaciones de poder, su interpretacion deficiente del concepto de capital social y su definicion de un sentido de pertenencia social.
Social Work with Groups: A Comprehensive Workbook

Using a plentiful selection of skill-building and self-evaluation exercises, author Charles Zastrow's comprehensive, workbook-style text promotes his philosophy that you can learn group leadership skills best by practicing them in class. In this seventh edition of SOCIAL WORK WITH GROUPS: A COMPREHENSIVE WORKBOOK, Zastrow discusses topics central to a successful understanding of group leadership: stages of groups, group dynamics, verbal and nonverbal communication, types of groups, and diversity in groups. When you participate in groups, the classroom becomes a "lab" where you can experience what it's like to work in and lead the many kinds of groups the author discusses.
Unsolved mysteries of the mind : tutorial essays in cognition

Soluble and insoluble mysteries of the mind, V. Bruce visual illusions, M.J. Morgan reality and imagination, V. Bruce control of mental processes, S. Monsell consciousness, A. Young, N. Block why do we have Emotions? P.T. Smith, S.M. Kemp-Wheeler Can Animals Think? S. Lea, M. Kiley-Worthington.