Miracle-dz/UniFAR-FTUs huggingface dataset:
Vasopressin-stimulated Increase in Phosphorylation at Ser269 Potentiates Plasma Membrane Retention of Aquaporin-2*

Vasopressin controls water excretion through regulation of aquaporin-2 (AQP2) trafficking in renal collecting duct cells. Using mass spectrometry, we previously demonstrated four phosphorylated serines (Ser256, Ser261, Ser264, and Ser269) in the carboxyl-terminal tail of rat AQP2. Here, we used phospho-specific antibodies and protein mass spectrometry to investigate the roles of vasopressin and cyclic AMP in the regulation of phosphorylation at Ser269 and addressed the role of this site in AQP2 trafficking. The V2 receptor-specific vasopressin analog dDAVP increased Ser(P)269-AQP2 abundance more than 10-fold, but at a rate much slower than the corresponding increase in Ser256 phosphorylation. Vasopressin-mediated changes in phosphorylation at both sites were mimicked by cAMP addition and inhibited by protein kinase A (PKA) antagonists. In vitro kinase assays, however, demonstrated that PKA phosphorylates Ser256, but not Ser269. Phosphorylation of AQP2 at Ser269 did not occur when Ser256 was replaced by an unphosphorylatable amino acid, as seen in both S256L-AQP2 mutant mice and in Madin-Darby canine kidney cells expressing an S256A mutant, suggesting that Ser269 phosphorylation depends upon prior phosphorylation at Ser256. Immunogold electron microscopy localized Ser(P)269-AQP2 solely in the apical plasma membrane of rat collecting duct cells, in contrast to the other three phospho-forms (found in both apical plasma membrane and intracellular vesicles). Madin-Darby canine kidney cells expressing an S269D “phosphomimic” AQP2 mutant showed constitutive localization at the plasma membrane. The data support a model in which vasopressin-mediated phosphorylation of AQP2 at Ser269:(a) depends on prior PKA-mediated phosphorylation of Ser256 and (b) enhances apical plasma membrane retention of AQP2.
COMPARISON OF ARTIFICIAL NEURAL NETWORK APPROACH AND DATA MINING TECHNIQUE FOR THE PREDICTION OF SURFACE ROUGHNESS IN END MILLED COMPONENTS WITH TEXTURE IMAGES

This article presents a procedure for using machine vision data to predict surface roughness parameter of the end milled components. Stylus based surface roughness measurements were used and compared to vision based prediction of surface roughness. Wavelet decomposition was used to extract features from vision based data. In this article wavelet Energy features of approximations and details were extracted. The proposed method utilized two different classification techniques. M5P Decision tree was used as one of the technique to classify and correlate surface roughness of milled components. Artificial Neural network was another technique. The obtained surface roughness values were compared with the stylus type surface roughness measurement. It is found that artificial neural network classification outperforms the M5P decision tree.
Voices Silenced, Voices Heard: Exploring Status, Discourse, and Learning in Middle School Discussion Groups

Purpose: Cooperative learning structures allow diverse groups of students to learn together while developing higher-order thinking skills, yet there are concerns that not all students’ voices are being heard. The intent of this study was to discover the relationship between the instructional methodologies one teacher used to foster the development of group skills in students and the ways small discussion groups actually functioned. This study explored issues of power and status on students’ learning opportunities in middle school discussion groups. Method: This qualitative study was conducted under an ethnographic lens using a teacher-as-researcher approach. Data were collected over one school year in a sixth grade classroom from two different class groups. Data sources included field notes, audio and video-recordings, and teacher observations of groups. A sociometric device was used to measure the peer status of the forty-eight student participants. Thirty-one recordings of student discussion groups were transcribed and analyzed using Fairclough’s (2004) methods of critical discourse analysis. Transcripts were coded for Mercer’s (1995) three types of talk: disputational, cumulative, and exploratory. Student participation was measured as a percentage of total group discussion. Students’ peer status, gender, and participation rates were compared. Analysis/Results: In one class group, a relationship was found between gender, status, and participation. Students gradually adopted the genre, discourse, and style of academic discussions. Students with low peer status increased participation rates over time, and students with high peer status decreased participation rates over time. Five student participation patterns emerged from the data: facilitating, contributing, dependent, silent, and distracting. The percentage of total group talk spent on disputational and organizational talk decreased over time while cumulative and exploratory talk increased. Discussion: Peer status effects were found in one class group, but these effects decreased as students developed academic discussion skills. Students’ high-level thinking and talking increased over the school year. Connections can be made between instruction of academic discourse and student success in discussion groups. Examination of the five patterns of student participation provides insight into how to foster high-level discussion skills in students. The generalizability of this study to other educational settings is addressed.
Stochastic models for turbo decoding

This paper proposes a stochastic framework for modelling and analysis of turbo decoding. By modelling the input and output signals of a turbo decoder as random processes, we prove that these signals become ergodic when the code block size becomes very large. This basic result allows us to easily model and compute the statistics of the signals in a turbo decoder. Using the ergodicity result and the fact that a sum of lognormal distributions is well approximated using a lognormal distribution, we show that the input-output signals in a turbo decoder, when expressed using the so-called scaled log-likelihood ratios, are well approximated using Gaussian distributions. Combining the two results above, we can model a turbo decoder using two inputs and two outputs (corresponding to the means and variances). Using this model, we have discovered that a typical decoding process is much more intricate than previously known, involving two regions of attractions, several fixed points, and a stable equilibrium manifold at which all decoding trajectories converge.
Analysis of Collection of Hemolytic Uremic Syndrome–associated Enterohemorrhagic Escherichia coli

Multilocus sequence typing of 169 non-O157 enterohemorrhagic Escherichia coli (EHEC) isolated from patients with hemolytic uremic syndrome (HUS) demonstrated 29 different sequence types (STs); 78.1% of these strains clustered in 5 STs. From all STs and serotypes identified, we established a reference panel of EHEC associated with HUS (HUSEC collection).
A Comparative Investigation on PMEPR Reduction Algorithms for STBC-OFDM Signals

This paper evaluates the peak-to-mean envelope power ratio (PMEPR) performance in a space-time block coded (STBC) OFDM system using the selective mapping (SLM) and partial transmit sequence (PTS) approaches. The investigated SLM and PTS schemes for STBC-OFDM signals select the transmitted sequence with the lowest average PMEPR over all transmit antennas and retrieve the side information (SI) very accurately at the expense of a slight degradation of the PMEPR performance. The low probability of false SI can improve the overall detection performance of the STBC-OFDM system with erroneous side information compared to the ordinary SLM and PTS approaches, respectively.
Competitive Position of Primary Airports in the Asia-Pacific Rim

This paper measures and compares the network performance and hub competitive position of primary airports in the Asia-Pacific rim, taking into account the quantity and quality of both direct and indirect connections. The results reveal that Tokyo has the best network performance and hub competitive position. The most striking growth of network development is found at Chinese airports, while network performance deteriorates at Oceanian airports. Finally, the results show that the position of Oneworld and Star Alliance is stronger in this region, whereas SkyTeam has an innegligible position especially at Japanese airports, owing to the fifth and sixth freedom rights.
Multi-camera detection association for 3D localisation

A multi-camera system is described for 3-D localisation of subjects within a confined space. In particular, we present a novel neighbourhood association algorithm to solve the problem of associating detections in multiple camera views with subjects. To evaluate our approach, experiments were conducted using multiple view video sequences of up to four subjects simulating typical passenger behaviour on a bus. ROC curves were generated for three different versions which showed that for smaller values of the neighbourhood radius parameter, the system tended to over-estimate the number of subjects. However, increasing the radius reduced the over-estimation from 60% to 5%.
Generalized transmitted-reference UWB systems

Transmitted-reference (TR) ultra-wideband (UWB) wireless communication systems [R. Hoctor et al., Jan. 2002] can relax the difficult UWB timing requirements and can provide a simple receiver that gathers the energy from the many resolvable multipath components. However, TR-UWB's relatively poor bit error rate (BER) performance and low data rate have limited its application. In this paper, the TR-UWB idea is generalized to address both of these issues. In particular, the aspects of the system that provide the desirable multipath gathering ability and timing attributes are retained, while the remainder of the system is optimized, resulting in a significantly different signaling scheme and receiver back-end. Numerical results for two examples indicate a significant BER improvement over standard TR-UWB under the same timing requirement.
Multiple causes of sexual segregation in European red deer: enlightenments from varying breeding phenology at high and low latitude

Sexual segregation outside the mating season occurs in most species of sexually dimorphic ungulates and has been extensively described in the literature, but the mechanisms causing segregation are still debated. The detailed pattern of sexual segregation throughout the year has rarely been presented for mammals, and no study, to our knowledge, has used latitudinal–related variation in breeding phenology to shed light on the underlying mechanisms. Recent methodological developments have made it possible to quantify separate components of segregation (social, habitat) and activity synchrony in animal groups, but these major improvements have so far been little used. We observed European red deer year round at two widely different latitudes (France and Norway) and tested three different mechanistic hypotheses of segregation related to: (i) predation risk; (ii) body–size–related forage selection; and (iii) activity budget. Habitat segregation peaked during calving in both populations and dropped rapidly after calving. Females with calves were more segregated from males than were females without calves, pointing to a key role of anti–predator behaviour even though large predators are absent in France and extremely rare in Norway. However, at both sites individuals also grouped with their own sex within habitat types (i.e. social segregation), and individuals in mixed–sex groups were less synchronized in activity type than individuals in either unisex male or unisex female groups, suggesting that differences in activity budgets are involved. Social segregation peaked during calving and was lowest during the rut (indicating aggregation) in both populations; these activities occurred one month later in the Northern populations, corresponding well with known differences in breeding phenology. We conclude that latitude–dependent breeding phenology shapes the seasonal pattern of sexual segregation and that sexual segregation in ungulates has multiple causes.
Gallstone disease

Gallstone disease is one of the most prevalent gastrointestinal diseases with a substantial burden to health care systems that is supposed to increase in ageing populations at risk. Aetiology and pathogenesis of cholesterol gallstones still are not well defined, and strategies for prevention and efficient nonsurgical therapies are missing. This review summarizes current concepts on the pathogenesis of cholesterol gallstones with focus on the uptake and secretion of biliary lipids and special emphasis on recent studies into the genetic background.
Dynamic voltage scaling on MPEG decoding

A number of research efforts have been devoted to reduce energy consumption of a processor without impacting the performance through the use of dynamic voltage scaling (DVS). The paper presents two DVS algorithms on MPEG decoding. One is DVS with delay and drop rate minimizing algorithm (DVS-DM) where voltage is determined based on previous workload only. Another algorithm scales the supply voltage according to the predicted MPEG decoding time and previous workload (DVS with predicted decoding time or DVS-PD). Simulation results show that DVS-PD improves energy efficiency as much as 56% compared to the conventional shutdown algorithm. We also found that the amount of energy saving with DVS-PD is not affected by the fluctuation of the movie stream, but is related to the error rate of the predictor, which implies that if decoding time is predicted more accurately, the DVS algorithm can be more efficient.
Diversity and multiplexing tradeoff in the uplink of cellular systems with linear MMSE receiver

In this paper, we extend the diversity and multiplexing tradeoff (DMT) analysis from point-to-point channels to cellular systems to evaluate the impact of inter-cell interference on the system reliability and efficiency. Fundamental tradeoff among diversity order, multiplexing gain and inter-cell interference intensity is characterized to reveal the capability of multiple antennas in cellular systems. And the detrimental effects of the inter-cell interference on the system performance of diversity and multiplexing is presented and analyzed.
The Evidentiary Significance of Case Reports: Eye Rubbing and Keratoconus

Purpose. Individual case reports (observational or interventional) are thought to have a very low ranking for evidentiary significance. This clinical report examines the relationship between the evidentiary significance of case reports and their presentation. Methods. An observational report of unilateral keratoconus (KC), that developed in association with a corresponding unilateral chronic habit of abnormal rubbing, is examined to identify features that can raise the level of evidentiary significance. Results. A feature of this type of case is the opportunity to compare the eye with KC to the unaffected eye, for which there was an unremarkable rubbing history. The unaffected eye serves as a retrospective unintentional control for the affected eye. Detailed assessment to establish the normality of the apparently normal eye is crucial to the differential diagnosis between a markedly asymmetric presentation and a true unilateral presentation. Any history of systemic diseases that may be associated with the presenting disease can be important. Longitudinal follow-up, especially if postonset data are supplemented with preonset data, can contribute to the evidentiary base by allowing for comparison with the natural history of the relevant disease. Intervention to remove a suspected causal factor, when combined with appropriate follow-up, can provide additional evidence. Conclusions. Depending on their presentation, some types of case report can have a significant evidence-based function in assessing causal hypotheses and, accordingly, provide a higher evidentiary ranking than generally assigned to case reports. The potential for a higher evidentiary ranking may be more important when randomized clinical trials are contraindicated for ethical reasons, or there are challenging problems with study design. Wider agreement regarding the quantitative and qualitative criteria for diagnosing the earliest stages of KC would aid the assessment of the evidentiary significance of case reports of this disease.
Creativity-Based Assessment and Neural Understandings: A Discussion and Case Study Analysis.

Purpose – Enabling entrepreneurial creativity is a key aim of UK Government; however, there is a dearth of constructively aligned models of teaching and assessment. This paper aims to introduce design‐based pedagogies and to highlight cognitive approaches that develop innovative mindsets; it seeks to indicate their propensity for adoption in entrepreneurship education.Design/methodology/approach – A literature review plus empirical evidence from pedagogical approaches developed through the extended collaboration of specialists in creative design, financial management and brain‐related occupational therapy inform this paper.Findings – Neuroimaging studies challenge the thesis that learning for creative output is entirely algorithmic; diverse ideas occur when the brain's right cortex has opportunity to bring its findings to the fore, usually via “relaxed cognition”. Design‐based entrepreneurship pedagogies embed these concepts.Research limitations/implications – The paper offers initial insights into how th.
Differentiation of CD3-4-8- thymocytes in short-term thymic stromal cell culture

We have investigated the ability of a heterogeneous thymic stromal cell (HTSC) culture system to promote in vitro differentiation of CD3-4-8- thymocytes. Culture of purified murine CD3-4-8- thymocytes on HTSC for 1 d resulted in the appearance of CD4+8+ cells, which did not occur when the sorted cells were maintained in medium alone. It is remarkable that when the culture period was extended to 2 d, CD3-4-8- progenitors differentiated further to CD4+8- and CD4-8+ cells, which also expressed high levels of TCR-CD3. This rapid differentiation on stroma in vitro appears to outpace parallel development in vivo. The differentiation potential of a subset of CD3-4-8- thymocytes that express high levels of a marker of normal and neoplastic thymic progenitors, the 1C11 antigen, was examined next. 1C11hiCD3-4-8- cells also gave rise to CD4- 8+ and CD4+8+ populations after 1 d of culture on HTSC. Extending the culture period to 2 d resulted in a significant percentage of CD3- expressing cells that were CD4+8+, CD4+8- and CD4-8+ cells. These results suggest that in the in vitro HTSC culture system, various subsets of immature thymocytes can differentiate into all the mature phenotypes of cells normally found in the adult mouse thymus. This may provide a novel and rapid assay for thymic progenitors.
Nonresponsiveness to standard treatment in cutaneous leishmaniasis: A case series from Sri Lanka

Leishmaniasis is caused by parasitic protozoa of the genus Leishmania. Cutaneous leishmaniasis (CL) is endemic in Sri Lanka with over 3000 cases during the last decade and numbers are increasing. Treatment options available in Sri Lanka for CL include intralesional/intramuscular sodium stibogluconate and cryotherapy. Eight cases of treatment failure with standard therapy are reported from the Dermatology Clinic, Teaching Hospital Anuradhapura. Therapeutic regimes aim for clinical healing, these patients responded poorly to anti-leishmanial therapy, indicating the need for close monitoring, explore alternative treatment options and to investigate for drug resistance in parasites.
Ieee Transactions on Parallel and Distributed Systems, Manuscript Id 1 Utility Accrual Dynamic Routing in Real-time Parallel Systems

— One of the main properties of today's distributed and parallel systems, such as mobile ad-hoc networks and grids, is their heterogeneity in the available resources. Further, many applications of such systems are subject to Time/Utility Function (TUF) time constraints for jobs, unavoidable variability in job characteristics and arrivals, and statistical assurance requirements on timeliness behaviors. In this paper, we propose an exact analytical solution for performance evaluation of dynamic policies used for routing of TUF-constrained Firm Real-Time (FRT) jobs among parallel single-processor queues with arbitrary processing rates and capacities. The analytical method can be used for the evaluation of the compliance of some important statistical assurance requirements. Furthermore, we present a utility-aware dynamic routing policy to improve the expected accrued utility of the parallel system. The policy called Maximum Expected Utility (MEU) behaves based on the information gathered from the analytical solution. MEU is compared with some well-known Dynamic Routing (DR) policies for different TUF shapes and both cases of homogeneous and heterogeneous processors of a two-queue system. The comparisons show the efficiency of MEU for the former case and its good behavior in most situations for the latter case.
Effects of age and aerobic fitness on heart rate recovery in adult men.

BACKGROUND Physiological aging leads to cardiac autonomic dysfunction, which is associated with the onset and worsening of cardiovascular disease and an increased risk of death. Currently, physical exercise is considered a cardioprotective strategy and more research is needed on its benefit on cardiac autonomic function. OBJECTIVE To evaluate the autonomic control of heart rate in healthy young and middle-aged volunteers with different levels of aerobic fitness. METHODS The study included 68 volunteers, stratified for age and level of aerobic fitness. Based on aerobic fitness assessed by the submaximal exercise test, subjects were separated into two groups, good fitness and poor fitness. Assessment of cardiac autonomic control was performed based on measurements of heart rate variability at rest and heart rate recovery post-exercise. Analysis of variance with two factors was used to compare the variables investigated. RESULTS The heart rate variability is significantly lower in middle-aged volunteers than in young individuals, regardless of the aerobic fitness level (p <0.01). Higher levels of aerobic fitness in middle-aged volunteers are associated with earlier post-effort vagal reentry - rate of HR decline after 1min30s: 39.6% good aerobic fitness vs. poor 28.4% (p < 0.01). CONCLUSION Better levels of aerobic fitness act beneficially on the autonomic control of post-exercise heart rate, preserving the vagal reentry velocity in healthy middle-aged volunteers. However, it does not attenuate the decrease in heart rate variability due to the natural aging process.
El flujo migratorio en México: Un análisis histórico a partir de indicadores socioeconómicos

Mexican migration has a long historical tradition with our American neighbor, occupying a unique place in this relationship. Changes submitted through its history have increased the interest and concern among scholars of the subject we are concerned about the violations of the human rights of these migrants. Is through the history of migration where we have seen how it has evolved this phenomenon, which has given us the tools to create policies and improve the conditions of life of our people and their families.