Miracle-dz/UniFAR-FTUs huggingface dataset:
Development of Geospatial Dashboard with Analytic Hierarchy Processing for the Expansion of Branch Office Location

One of the considered business opportunities that exploit the geographical aspect is the branch office expansion. However, this activity still has some problems to learn various location criteria, either in quantitative or qualitative form. Moreover, there is a need to analyze those criteria quickly to get a proper location priority that will be expanded. Therefore, this research develops a semantic technology of the form geospatial dashboard using analytic hierarchy processing (AHP) method that can display the distribution of location and its criteria in a map. Furthermore, it recommends the list of top priority locations will be expanded implicitly from the various kinds of data. This research takes a case study in one local company in Indonesia. At the end, this research shows that geospatial dashboard using AHP method is considered capable of producing accurate solution up to 90.48% to determine the priority order of locations to be expanded. Keyword: analytic hierarchy processing, geospatial dashboard, business intelligence, geographic information system, expansion of branch office location
Body mass index, airflow obstruction and dyspnea and body mass index, airflow obstruction, dyspnea scores, age and pack years-predictive properties of new multidimensional prognostic indices of chronic obstructive pulmonary disease in primary care

Background: The assessment of the severity of chronic obstructive pulmonary disease (COPD) should involve a multidimensional approach that is now clearly shown to be better than using spirometric impairment alone. The aim of this study is to validate and compare novel tools without an exercise test and to extend prognostic value to patients with less severe impairment of Forced expiratory volume 1 s. Methods: A prospective, observational, primary care cohort study identified 458 eligible patients recruited from the primary care clinics in the northeast of England in 1999–2002. A new prognostic indicator - body mass index, airflow obstruction and dyspnea (BOD) together with the conventional prognostic indices age, dyspnea and airflow obstruction (ADO), global initiative for chronic obstructive lung disease (GOLD) and new GOLD matrix were studied. We also sought to improve prognostication of BOD by adding age (A) and smoking history as pack years (S) to validate BODS (BOD with smoking history) and BODAS (BOD with smoking history and age) as prognostic tools and the predictive power of each was analyzed. Results: The survival of the 458 patients was assessed after a median of 10 years when the mortality was found to be 33.6%. The novel indices BOD, BODS, and BODAS were significantly predictive for all-cause mortality in our cohort. Furthermore with ROC analysis the C statistics for BOD, BODS, and BODAS were 0.62, 0.66, and 0.72, respectively (P < 0.001 for each), whereas ADO and GOLD stages had a C statistic of 0.70 (P < 0.001) and 0.56 (P < 0.02), respectively. GOLD Matrix was not significant in this cohort. Conclusion: BOD, BODS, and BODAS scores are validated predictors of all-cause mortality in a primary care cohort with COPD.
Creating Rat Model for Hypoxic Brain Damage in Neonates by Oxygen Deprivation

Current study explores the feasibility of using a non-surgical method of oxygen deprivation to create Hypoxic brain damage in neonatal rats for medical studies. 7-day-old Sprague Dowley (SD) rats were kept in a container with low oxygen level (8%) for 1.5h. A second group had bilateral cephalic artery ligation before the 1.5h-low oxygen treatment, a method similar to the popular Rice method, to expose the brain to both hypoxic and ischemic situations. Short term neural functions and brain water weights were evaluated 1 day after the hypoxic treatment. Brain pathology and histology were also examined at 1 day and 3 days after the hypoxic treatment. Both groups showed impaired neural functions and increased brain water weight compared to the controls. Histology studies also revealed injuries in the subcortex, hippocampus and lateral ventricle in the brains from both groups. There is no significant difference in the degree of brain damages observed in the two groups. Our work demonstrated that oxygen deprivation alone is sufficient to cause brain damages similar to those seen in Hypoxic-ischemic brain disease (HIBD). Because this method avoids the invasive surgical procedure and therefore reduces the stress and mortality of laboratory animals during the experiment, we recommend it to be the favorable method for creating rat models for HIBD studies.
Nanoscale Measurement of Stress and Strain by Quantitative High-Resolution Electron Microscopy

The geometric phase technique (GPA) for measuring the distortion of crystalline lattices from high-resolution electron microscopy (HRTEM) images will be described. The method is based on the calculation of the “local” Fourier components of the HRTEM image by filtering in Fourier space. The method will be illustrated with a study of an edge dislocation in silicon where displacements have been measured to an accuracy of 3 pm at nanometre resolution as compared with anisotropic elastic theory calculations. The different components of the strain tensor will be mapped out in the vicinity of the dislocation core and compared with theory. The accuracy is of the order of 0.5% for strain and 0.1° for rigid-body rotations. Using bulk elastic constants for silicon, the stress field is determined to 0.5 GPa at nanometre spatial resolution. Accuracy and the spatial resolution of the technique will be discussed.
The Design and Implementation of AQuA: An Adaptive Quality of Service Aware Object-Based Storage Device

As storage systems are becoming larger and more complicated, they must handle an increasing variety of data storage needs. Storage system Quality of Service (QoS) has therefore become an important issue. Storage systems must be able to deliver satisfactory performance under both expected and unexpected workloads and, increasingly, must handle data (such as multimedia data) with real timeliness requirements. We are developing a petascale high-performance distributed object-based storage system called Ceph. Ceph’s object storage architecture and other unique features have given rise to new QoS issues that require new solutions. In this paper, we first discuss the issues involved with the design of the overall QoS framework, we then present the design and implementation of AQuA, an adaptive QoS-aware object-based storage device (OSD) suitable for use as the fundamental building block in an overall QoS-capable object-based storage system.
Inequality in Addiction and Mental Disorders in 6818 Suicide Attempts: Determine of Positive Contribution of Determinants by Decomposition Method

Background: Unpleasant health outcomes are common in deprived communities and have been shown a direct connection between socioeconomic status and wellbeing but, the effect of the socioeconomic status on suicide is currently controversial. This study explored the relationship of the socioeconomic status and addiction and mental disorders in suicide attempts and decomposed inequalities into its determinants to calculating share of contribution to the inequality. Methods: This cross-sectional study recognized 546 suicide deaths and 6818 attempted suicides from 1 Jan 2010 to 31 Dec 2014 in Ilam Province, West of Iran. Inequality measured by concentration index (CI) and decomposing contribution in inequality. All analysis was performed by standard statistical software, Stata (Ver. 11.2). Results: The pooled rate of death in people with suicide attempts was 8.0% and that of having a history of suicide was 5.2%. The overall CI for addiction was −0.233 (95% CI= −0.383 to −0.084), and the CI for mental disorders was 0.0006 (95% CI = −0.009 to 0.010). The more amount of contribution to socioeconomic inequality in suicide attempts because of age group of < 25 yr (26%), socioeconomic level (23%), and marital status (22%). Conclusion: Addiction and mental disorders were distributed among suicide attempters unequally and gap between advantaged and disadvantaged attempted suicide confirmed by our results. Addiction prevention-related policies and programmers’ should be focus on disadvantaged groups.
Quality in health care

The purpose of the article is to present quality and its importance in healthcare. The article provides the definition of quality in reference to healthcare. In this paper, we concentrate on three dimensions of quality of medical services and its shaping factors. The principles of building a quality management system which remains the basis of quality standards in health care are presented.
Mitochondrial DNA recombination in a free-ranging Australian lizard

Mitochondrial DNA (mtDNA) is the traditional workhorse for reconstructing evolutionary events. The frequent use of mtDNA in such analyses derives from the apparent simplicity of its inheritance: maternal and lacking bi-parental recombination. However, in hybrid zones, the reproductive barriers are often not completely developed, resulting in the breakdown of male mitochondrial elimination mechanisms, leading to leakage of paternal mitochondria and transient heteroplasmy, resulting in an increased possibility of recombination. Despite the widespread occurrence of heteroplasmy and the presence of the molecular machinery necessary for recombination, we know of no documented example of recombination of mtDNA in any terrestrial wild vertebrate population. By sequencing the entire mitochondrial genome (16 761 bp), we present evidence for mitochondrial recombination in the hybrid zone of two mitochondrial haplotypes in the Australian frillneck lizard (Chlamydosaurus kingii).
Apoptotic Death of Cancer Stem Cells for Cancer Therapy

Cancer stem cells (CSCs) play crucial roles in tumor progression, chemo- and radiotherapy resistance, and recurrence. Recent studies on CSCs have advanced understanding of molecular oncology and development of novel therapeutic strategies. This review article updates the hypothesis and paradigm of CSCs with a focus on major signaling pathways and effectors that regulate CSC apoptosis. Selective CSC apoptotic inducers are introduced and their therapeutic potentials are discussed. These include synthetic and natural compounds, antibodies and recombinant proteins, and oligonucleotides.
The Influence of Loading Rate on the Ultimate Properties and Fracture Mechanism of Styrenic Thermoplastic Elastomers

The influence of loading rate on the tensile fracture of polystyrene-polyisoprenepolystyrene (SIS) and polystyrene-poly(ethylene-co-butylene)-polystyrene (SEBS) has been investigated. The tensile strength of SIS initially increased with increasing strain rate, eventually reaching a plateau at elevated strain rates. In contrast, the tensile strength of SEBS was relatively unaffected by strain rate. The fracture surfaces of the tensile test specimens were examined by scanning electron microscopy. The fracture surface morphologies indicated that fracture initiated via cavitation, followed subsequently by void coalescence and catastrophic fracture. For both materials there was no qualitatively obvious change in fracture surface morphology with increasing strain rate. The results indicate that the ultimate strength of styrenic thermoplastic elastomers is governed by the nature of the dominant failure mechanism at the molecular scale; when chain scission dominates, the tensile strength is independent of the strain rate, but when chain pull-out dominates, the tensile strength increases with increasing strain rate.
Coordination and antenna domain formation in cloud-RAN systems

We study here the problem of Antenna Domain Formation (ADF) in cloud RAN systems, whereby multiple remote radio-heads (RRHs) are each to be assigned to a set of antenna domains (ADs), such that the total interference between the ADs is minimized. We formulate the corresponding optimization problem, by introducing the concept of interference coupling coefficients among pairs of radio-heads. We then propose a low-overhead algorithm that allows the problem to be solved in a distributed fashion, among the aggregation nodes (ANs), and establish basic convergence results. Moreover, we also propose a simple relaxation to the problem, thus enabling us to characterize its maximum performance. We follow a layered coordination structure: after the ADs are formed, radio-heads are clustered to perform coordinated beamforming using the well known Weighted-MMSE algorithm. Finally, our simulations show that using the proposed ADF mechanism would significantly increase the sum-rate of the system (with respect to random assignment of radio-heads).
Molecular Implication of PP2A and Pin1 in the Alzheimer's Disease Specific Hyperphosphorylation of Tau

Background Tau phosphorylation and dephosphorylation regulate in a poorly understood manner its physiological role of microtubule stabilization, and equally its integration in Alzheimer disease (AD) related fibrils. A specific phospho-pattern will result from the balance between kinases and phosphatases. The heterotrimeric Protein Phosphatase type 2A encompassing regulatory subunit PR55/Bα (PP2AT55α) is a major Tau phosphatase in vivo, which contributes to its final phosphorylation state. We use NMR spectroscopy to determine the dephosphorylation rates of phospho-Tau by this major brain phosphatase, and present site-specific and kinetic data for the individual sites including the pS202/pT205 AT8 and pT231 AT180 phospho-epitopes. Methodology/Principal Findings We demonstrate the importance of the PR55/Bα regulatory subunit of PP2A within this enzymatic process, and show that, unexpectedly, phosphorylation at the pT231 AT180 site negatively interferes with the dephosphorylation of the pS202/pT205 AT8 site. This inhibitory effect can be released by the phosphorylation dependent prolyl cis/trans isomerase Pin1. Because the stimulatory effect is lost with the dimeric PP2A core enzyme (PP2AD) or with a phospho-Tau T231A mutant, we propose that Pin1 regulates the interaction between the PR55/Bα subunit and the AT180 phospho-epitope on Tau. Conclusions/Significance Our results show that phosphorylation of T231 (AT180) can negatively influence the dephosphorylation of the pS202/pT205 AT8 epitope, even without an altered PP2A pool. Thus, a priming dephosphorylation of pT231 AT180 is required for efficient PP2AT55α-mediated dephosphorylation of pS202/pT205 AT8. The sophisticated interplay between priming mechanisms reported for certain Tau kinases and the one described here for Tau phosphatase PP2AT55α may contribute to the hyperphosphorylation of Tau observed in AD neurons.
INHIBITION OF CANDIDA ALBICANS GROWTH ON SURFACES TREATED BY DIELECTRIC BARRIER DISCHARGE WITH VARIOUS BARRIERS

Discharges generating low temperature plasma at atmospheric pressure have the potential to treat surfaces biologically contaminated by organic matter in a non-destructive manner. We have been studying ways of inhibiting the growth of microorganisms with the use of dielectric barrier discharge (DBD) plasma. The effect of the choice of a barrier material and its thickness on the germicide properties of the DBD is described. We used Saboraud agar inoculated by 10 5 cfu/cm 2 of Candida albicans yeast as the model contaminated surface. After cultivation, the proportion of the treated surface with no C. albicans colony was evaluated.
Safety implications of nanoparticles

Nanoparticles are characterised with their near atomic scales, usually between 1 nanometer and 100 nanometers. These particles have recently gained popularity due to their huge surface area that has the potential to alter the behaviour of individual molecules. Nanotechnology is concerned with manipulating matter to a nanoscale and has great commercial potential. Nanoparticles' extremely small size makes them much easier to penetrate into human body and, possibly, cause adverse effects on health. This paper aims at determining what is known about the state of safety of nanoparticles through an extensive literature review. In light of this review, a framework for future research to ascertain the safe use of nanoparticles is suggested.
Structure of Human Skeletal Keratosulf ate

Keratosulfate from old human rib cartilage (KS II) was fractionated into two fractions on Bio-Gel P-6 resin. Glutamic acid or glutamine, serine, proline, and galactosamine were concentrated in the higher molecular weight fraction, whereas aspartic acid or asparagine was concentrated in the retarded peak. During alkaline treatment the higher molecular weight fraction became polydisperse through breaking of bonds involving N-acetylgalactosamine as well as serine and threonine. Studies of the action of alkali on KS II in the presence and absence of borohydride have led to the following conclusions: (a) The predominant 0-glycosyl group linked to the hydroxyamino acids appears to be N-acetylgalactosamine. 0) A direct Ehrlich’s chromogen is produced during the alkaline elimination, which parallels the decrease in seryl and threonyl groups. (c) When KS II or a product of KS II produced by partial hydrolysis with N acetic acid is treated with alkali in the presence of borohydride at 24”, a new ninhydrin-positive fraction is produced after hydrolysis in HCl. This is presumably derived from a 3-substituted N-acetylgalactosamine. The same fraction appears when N-acetylchondrosine or a tetrasaccharide derived from chondroitin 6-sulfate is treated with alkaline borohydride but not when a tetrasaccharide of hyaluronic acid is thus treated. The unknown derivative of N-acetylgalactosamine apparently is a reduction product of the unsaturated chromogen I postulated by Kuhn. (d) The chromogen produced by alkaline elimination appears to be still attached to a high molecular weight product. Therefore, it must be linked in the original substance via an Oglycosidic bond to the hydroxyl groups of the hydroxyamino acids; it is substituted in position 3 and is further linked to position 6 by an alkali-stable bond.
Music classification method based on lyrics for music therapy

Music is used for people practicing sports, for elderly individuals, and to help train the mind. Recently in music information science, studies have been conducted on music therapy and on music classification from a therapeutic point of view. However, most of these studies have classified music based on melody and tempo. No classification method that is based on lyrics has been performed for music therapy support. In this paper, we propose a music classification method using emotional words included in lyrics toward music therapy. Music is classified by using a clustering method. In addition, this paper shows that a higher classification precision is obtained when compared with the conventional
Mechanisms of Dyslipoproteinemias in Systemic Lupus Erythematosus

Autoimmunity and inflammation are associated with marked changes in lipid and lipoprotein metabolism in SLE. Autoantibodies and cytokines are able to modulate lipoprotein lipase (LPL) activity, a key enzyme in lipid metabolism, with a consequent “lupus pattern” of dyslipoproteinemia characterized by elevated levels of very low-density lipoprotein cholesterol (VLDL) and triglycerides (TG) and lower high-density lipoprotein cholesterol (HDL) levels. This pattern favors an enhanced LDL oxidation with a subsequent deleterious foam cell formation. Autoantibodies and immunocomplexes may aggravate this oxidative injury by inducing accumulation and deposition of oxLDL in endothelial cells. Drugs and associated diseases usually magnify the close interaction of these factors and further promote the proatherogenic environment of this disease.
Seamless interpretation of the strength and fatigue lifetime of polycrystalline silicon thin films

Thin film polycrystalline silicon was subjected to strength and fatigue tests. A model is proposed which correlates the strength of this material under monotonic loading and its fatigue lifetime under cyclic loading in a seamless manner on a three-dimensional surface. This surface describes the cumulative failure probability as a function of both applied stress and fatigue cycles. In the first step, the statistical distribution of equivalent initial crack lengths corresponding to the defects introduced into the specimens in the etching process is deduced from the strength distribution of the specimens fabricated on a silicon wafer. From this distribution, the fatigue lifetime under different stress levels is estimated by applying the well-known Paris law of fatigue crack extension. The Paris law exponent determining the crack extension behavior as a function of the applied stress intensity factor was obtained by solving an inverse problem by fitting the estimated lifetime to the experimental results.
The term “asthma” should be avoided in describing the chronic pulmonary disease of prematurity

To the Editor : We read with interest the report from Kallen et al . [1] that preterm birth and (to a lesser extent) restricted intrauterine growth both substantially increase the risk of developing “childhood asthma”. Their data are interesting, and several plausible hypotheses are advanced to explain the correlation between prematurity (and intrauterine growth restriction) and the development of asthma later on. As in numerous other studies [2–4], cases of asthma were identified on the strength of anti-asthma drug prescriptions. Rightly enough, a persistent use of anti-asthma drugs (at least five prescriptions) was required to minimise the inclusion of non-asthmatic cases [1]. …
Passive smoking as well as active smoking increases the risk of acute stroke

OBJECTIVE To estimate the relative risk of stroke associated with exposure to environmental tobacco smoke (ETS, passive smoking) and to estimate the risk of stroke associated with current smoking (active smoking) using the traditional baseline group (never-smokers) and a baseline group that includes lifelong non-smokers and long-term (>10 years) ex-smokers who have not been exposed to ETS. DESIGN AND SETTING Population-based case-control study in residents of Auckland, New Zealand. SUBJECTS Cases were obtained from the Auckland stroke study, a population-based register of acute stroke. Controls were obtained from a cross-sectional survey of major cardiovascular risk factors measured in the same population. A standard questionaire was administered to patients and controls by trained nurse interviewers. RESULTS Information was available for 521 patients with first-ever acute stroke and 1851 community controls aged 35–74 years. After adjusting for potential confounders (age, sex, history of hypertension, heart disease, and diabetes) using logistic regression, exposure to ETS among non-smokers and long-term ex-smokers was associated with a significantly increased risk of stroke (odds ratio (OR) = 1.82; 95% confidence interval (95% CI) = 1.34 to 2.49). The risk was significant in men (OR = 2.10; 95% CI = 1.33 to 3.32) and women (OR = 1.66; 95% CI = 1.07 to 2.57). Active smokers had a fourfold risk of stroke compared with people who reported they had never smoked cigarettes (OR = 4.14; 95% CI = 3.04 to 5.63); the risk increased when active smokers were compared with people who had never smoked or had quit smoking more than 10 years earlier and who were not exposed to ETS (OR = 6.33; 95% CI = 4.50 to 8.91). CONCLUSIONS This study is one of the few to investigate the association between passive smoking and the risk of acute stroke. We found a significantly increased risk of stroke in men and in women. This study also confirms the higher risk of stroke in men and women who smoke cigarettes compared with non-smokers. The stroke risk increases further when those who have been exposed to ETS are excluded from the non-smoking reference group. These findings also suggest that studies investigating the adverse effects of smoking will underestimate the risk if exposure to ETS is not taken into account.