Miracle-dz/UniFAR-FTUs huggingface dataset:
The neurological wake-up test in severe pediatric traumatic brain injury: a long term, single-center experience

Objectives To describe the use and outcomes of the neurological wake-up test (NWT) in pediatric severe traumatic brain injury (pTBI). Design Retrospective single-center observational cohort study. Setting Medical-surgical tertiary pediatric intensive care unit (PICU) in a university medical center and Level 1 Trauma Center. Patients Children younger than 18 years with severe TBI [i.e., Glasgow Coma Scale (GCS) of ≤8] admitted between January 2010 and December 2020. Subjects with non-traumatic brain injury were excluded. Measurements and main results Of 168 TBI patients admitted, 36 (21%) met the inclusion criteria. Median age was 8.5 years [2 months to 16 years], 5 patients were younger than 6 months. Median initial Glasgow Coma Scale (GCS) and Glasgow Motor Scale (GMS) was 6 [3–8] and 3 [1–5]. NWTs were initiated in 14 (39%) patients, with 7 (50%) labelled as successful. Fall from a height was the underlying injury mechanism in those seven. NWT-failure occurred in patients admitted after traffic accidents. Sedation use in both NWT-subgroups (successful vs. failure) was comparable. Cause of NWT-failure was non-arousal (71%) or severe agitation (29%). Subjects with NWT failure subsequently had radiological examination (29%), repeat NWT (43%), continuous interruption of sedation (14%) or intracranial pressure (ICP) monitoring (14%). The primary reason for not doing NWTs was intracranial hypertension in 59%. Compared to the NWT-group, the non-NWT group had a higher PRISM III score (18.9 vs. 10.6), lower GCS/GMS at discharge, more associated trauma, and circulatory support. Nine patients (25%) died during their PICU admission, none of them had an NWT. Conclusion We observed limited use of NWTs in pediatric severe TBI. Patients who failed the NWT were indistinguishable from those without NWT. Both groups were more severely affected compared to the NWT successes. Therefore, our results may indicate that only a select group of severe pTBI patients qualify for the NWT.
Carbonic anhydrases in the cell wall and plasma membrane of Arabidopsis thaliana are required for optimal plant growth on low CO2

Introduction: Plants have many genes encoding both alpha and beta type carbonic anhydrases. Arabidopsis has eight alpha type and six beta type carbonic anhydrase genes. Individual carbonic anhydrases are localized to specific compartments within the plant cell. In this study, we investigate the roles of αCA2 and βCA4. 1 in the growth of the plant Arabidopsis thaliana under different CO2 regimes. Methods: Here, we identified the intracellular location of αCA2 and βCA4. 1 by linking the coding region of each gene to a fluorescent tag. Tissue expression was determined by investigating GUS expression driven by the αCA2 and βCA4. 1 promoters. Finally, the role of these proteins in plant growth and photosynthesis was tested in plants with T-DNA insertions in the αCA2 and βCA4 genes. Results: Fluorescently tagged proteins showed that αCA2 is localized to the cell wall and βCA4. 1 to the plasma membrane in plant leaves. Both proteins were expressed in roots and shoots. Plants missing either αCA2 or βCA4 did not show any growth defects under the conditions tested in this study. However, if both αCA2 and βCA4 were disrupted, plants had a significantly smaller above- ground fresh weight and rosette area than Wild Type (WT) plants when grown at 200 μL L−1 CO2 but not at 400 and 1,000 μL L−1 CO2. Growth of the double mutant plants at 200 μL L−1 CO2 was restoredif either αCA2 or βCA4. 1 was transformed back into the double mutant plants. Discussion: Both the cell wall and plasma membrane CAs, αCA2 and βCA4. 1 had to be knocked down to produce an effect on Arabidopsis growth and only when grown in a CO2 concentration that was significantly below ambient. This indicates that αCA2 and βCA4. 1 have overlapping functions since the growth of lines where only one of these CAs was knocked down was indistinguishable from WT growth. The growth results and cellular locations of the two CAs suggest that together, αCA2 and βCA4. 1 play an important role in the delivery of CO2 and HCO3 − to the plant cell.
Based Copula Reliability Estimation with Stress-Strength Model for Bivariate Stress under Progressive Type II Censoring

This study investigates the dependence between stress and component strength in a stress–strength model with bivariate stresses by incorporating a specialized Archimedean copula, specifically the 3-dimensional Clayton copula. Diverging from prior research, we consider a scenario where two stresses simultaneously influence the component strength, enhancing the realism of our model. Initially, dependent parameter estimates were obtained through moment estimation. Subsequently, maximum likelihood estimation and Bayesian estimation were employed to acquire point and interval estimates for the model parameters. Finally, numerical simulations and real-world data analysis were conducted to validate the accuracy and practicality of our proposed model. This research establishes a foundation for further exploration of general dependence structures and multi-component stress–strength correlation issues.
Making the most of incomplete long-term datasets: the MARSS solution

ABSTRACT Long-term field-based monitoring is essential to develop a deep understanding of how ecosystems function and to identify species at risk of decline. However, conducting long-term field-based research poses some unique challenges due to the harsh environmental conditions or extreme weather events that may be encountered. Such conditions are especially likely to occur in arid environments. Fieldwork issues can arise from vehicle breakdowns, wildfires and heavy rainfall events, all of which can delay or even cancel data collection. In addition, long-term monitoring typically requires multiple observers, which may add observation bias to estimates of measured parameters. Thus there is an increasing need to develop new statistical techniques that take advantage of the power of long time-series datasets that also are incomplete. Here we discuss multivariate autoregressive state-space (MARSS) modelling; a relatively new statistical technique for modelling long-term time-series data. MARSS models allow u.
The intention to adopt metaverse in Islamic banks: an integrated theoretical framework of TAM and religiosity intention model

Purpose This paper aims to explore the intention to adopt the Metaverse in Islamic banks, with a particular focus on evaluating perceived usefulness, ease of use, user satisfaction and the influence of religiosity. Integrating the technology adoption model (TAM) and religiosity intention model, this study will dissect the multidimensional aspects influencing the acceptance of Metaverse technologies. Design/methodology/approach Surveying Islamic bank professionals in Jordan, this study used a structured questionnaire and data augmentation to analyze Metaverse adoption factors. Using partial least squares-structural equation modeling, the relationships between ease of use, usefulness, religiosity and satisfaction were explored. Findings The study identifies pivotal relationships among perceived usefulness, ease of use, user satisfaction and religiosity in the context of adopting metaverse technologies in Islamic banks in Jordan. Evidence highlights the dominant role of perceived usefulness and ease in influencing both intention to use and satisfaction levels. Religiosity, while not a direct influencer, plays a collaborative role, underscoring a balanced mix of technological and religious elements that will potentially shape the adoption trajectory of metaverse technologies within this specific banking sector. Practical implications Integrating metaverse technologies in Islamic banks necessitates balancing technological advances with Sharia compliance. The study underscores the importance of aligning user experience with religious values and fostering innovation within Islamic ethical guidelines. Originality/value This study uniquely integrates the TAM and religiosity-intention model to explore metaverse adoption in Islamic banks, unveiling a nuanced interplay between technology and religious values. It offers practical insights for tailoring innovations in the Islamic financial ecosystem.
Stereotactic Navigation-Assisted Laparoscopic Resection of Challenging Low Pelvic Tumors: A Case Series

(1) Introduction: The laparoscopic approach to low pelvic tumors is challenging and hindered by suboptimal tumor visualization and dissection, with possible oncological failure. Stereotactic navigation provides real-time image guidance that may optimize safety, accuracy, and precision when dissecting challenging low pelvic tumors. (2) Methods: Preoperative CT images were acquired with eight skin-fixed fiducials and loaded into a navigation system. A patient tracker was mounted on the bed side. Patient-to-image paired point registration was performed, and an instrument tracker was mounted on a laparoscopic instrument and calibrated for instrument tracking. Surgical operations were performed with real-time stereotactic navigation assistance. (3) Results: Three patients underwent stereotactic navigation surgery. Fiducial registration errors were good to optimal (±1.9, ±3.4, and ±3.4 mm). Lesions were easily identified and targeted with real-time navigation. Surgeries were uneventful. Histopathology examinations identified one retro-rectal schwannoma, one lateral pelvic recurrence from rectal adenocarcinoma, and one advanced anal canal carcinoma. No navigation-related complications, readmissions, or postoperative mortalities were observed. (4) Conclusions: The application of laparoscopic stereotactic navigation surgery to complex low pelvic tumors is feasible and could impact oncological surgical quality by enabling tumor targeting and ensuring resection margins. Further wider series are needed to confirm stereotactic navigation’s impact on challenging low pelvic tumors.
Revisiting the Normal Form of Input-Output Linearization

—This paper revisits the normal form arising in the context of input-output feedback linearization for nonlinear control systems possessing well-deﬁned relative degree. The objective is to investigate the validity of the normal form in a neighbourhood of the zero dynamics manifold, as opposed to a neighbourhood of a point on the manifold. The two main results of the paper are necessary and sufﬁcient conditions under which the normal form exists in some neighbourhood of the zero dynamics manifold, or in a given a priori neighbourhood of the manifold in question. A special case is the existence of a global normal form. These results naturally lead to conditions for either local or regional (global, as a special case) asymptotic stabilization of the zero dynamics manifold. To illustrate these contributions, a normal form is derived for the kinematic unicycle model leading to a novel global circular path following controller.
Adapting to Service Quality; Building Public Trust through A Servqual Perspective

This article aims to analyze the quality management of madrasah services in building public trust in MAN 1 Tanjung Jabung Barat, Jambi. Public trust is included in the critical components to be taken into account. This is because competition in education is also heavily influenced by public trust. This study uses a qualitative approach to the type of case study. Data collection techniques are carried out through observation, interviews and documentation. Data analysis was carried out by referring to the concept of Milles and Huberman, namely data collection, data reduction, data presentation and conclusion. The research results were five forms of service quality management at MAN 1 Tanjung Jabung Barat, Jambi, in building public trust: applicable vision and mission, responsive human resources, communication forums, professional teaching staff and adequate teaching infrastructure. This research has implications for building and maintaining public trust for the continuity of education in madrasahs.
Engineering Interventions for Extraction of Essential Oils from Plants

Essential oils or etheric oils mean volatile oils and are obtained from plants by steam distillation method [19, 29]. Essential oils are used for medicinal and pharmaceutical purposes, food and food ingredients, herbal tea, cosmetics, perfumery, aromatherapy, pest and disease control, gelling agents, dying in fabrics, plant growth regulators and paper making, etc. Munir and Hensel [28] indicated that essential oils have been used in the medicinal and pharmaceutical purposes, as well as food industries, cosmetics, perfumes, physical therapy, the struggle of insects, diseases treatment, dye fabrics and jellies processing, plant growth regulator and manufacturing paper.
KONEKTIVITAS GENETIK Cephalopholis sexmaculata ANTARA DAERAH PENANGKAPAN DAN DAERAH KONSERVASI DI WILAYAH PENGELOLAAN PERIKANAN 714

The Fisheries Management Area (FMA 714) has great potential for reef fish with high diversity. However, exploitation of reef fish, especially grouper in FMA 714 is also high to meet national and international market demand. One of the species of grouper is Cephalopholis sexmaculata from the Serranidae family. This research was conducted with the aim to determine genetic distance and phylogenetic relationships as well as genetic diversity, population structure and genetic connectivity of the C. sexmaculata in conservation areas and fishing areas in FMA 714 using DNA barcoding. Samples of C. sexmaculata were collected using a survey method with analyzes carried out including molecular analysis, phylogenetic relationships as well as genetic diversity and connectivity. The results of the research show that the C. sexmaculata population in FMA 714 has a very close relationship with the the values of genetic distance ranging from 0-10.9%. The genetic diversity obtained also shows the value of 1 which is categorized as high in each population. The connectivity formed from the population structure of this species indicates the existence of genetic exchange between the C. sexmaculatapopulation in the conservation area and the fishing area in FMA 714. ABSTRAK Wilayah Pengelolaan Perikanan (WPP 714) memiliki potensi ikan karang yang besar dengan keragaman yang tinggi. Walaupun demikian, eksploitasi ikan karang terutama ikan kerapu di WPP 714 juga cukup tinggi untuk memenuhi permintaan pasar nasional dan internasional. Salah satu jenis ikan kerapu adalah Cephalopholis sexmaculata dari famili Serranidae. Penelitian ini dilakukan dengan tujuan untuk mengetahui jarak genetik dan hubungan filogenetik serta keragaman genetik, struktur populasi dan konektivitas genetik dari spesies C. sexmaculata antara daerah konservasi dan daerah penangkapan di WPP 714 dengan menggunakan DNA barcoding. Sampel ikan C. sexmaculata diperoleh menggunakan metode survei dengan analisis yang dilakukan meliputi analisis molekuler, hubungan kekerabatan atau filogenetik serta keragaman dan konektivitas genetik. Hasil penelitian menunjukan bahwa populasi C. sexmaculata di WPP 714 memiliki hubungan yang sangat dekat dengan jarak genetika yang diperoleh berkisar antara 0-10,9%. Nilai keragaman genetik yang diperoleh juga menunjukan angka 1 yang terkategori tinggi pada setiap populasi. Konektivitas yang terbentuk dari struktur populasi pada spesies ini menunjukan pendugaan terhadap adanya pertukaran genetik antara populasi C. sexmaculata di daerah konservasi dengan daerah penangkapan di WPP 714. Kata Kunci: WPP 714, Cephalopholis sexmaculata, penanda DNA, konektivitas, filogenetik
An Analytical Evaluation of Urban Open Space Policies in Nigeria

The governance of urban open spaces in Nigeria has been hindered by ineffective policy frameworks that are not sustainable. In-spite of all these challenges Urban Open Space provides sense of neighbourhood integration and also facilitates physical exercise and better mental health for urban residents. Efforts for sustainable frameworks yielded no notable accomplishments yet. Between June 2018 and March 2023, a literature review was conducted to enhance understanding. The review on Urban Open Space Policy employed a thorough analysis of published papers from reputable databases like Scopus and Web of Science. After careful screening, thirty relevant publications were selected, ensuring scholarly rigor in examining urban open space policy. Based on the findings, it is evident that there is currently no sustainable policy framework in place due to several factors such as urbanization, land use conversion/change, lack of stakeholder involvement in decision-making processes, and limited participation from professionals within the built environment sector. The complexities faced hinder the establishment of efficient governance in urban open spaces in Nigeria. It proposes the need for a policy framework considering stakeholders' interests to ensure long-term sustainability. Further studies should also focus on rural open spaces to reduce problem of urbanization in the urban areas.
REFRACTIVE INDEX ENGINEERING BY 3D SUB-WAVELENGTH NANOSTRUCTURING FOR APPLICATIONS IN OPTICS AND OPTICAL SENSING

In photonics, the flow of light in light-wave circuits is molded by optical materials and structures with different refractive indices. The ingenuities of photonic engineering are often curbed by the limited range in the refractive indices of naturally occurring optical materials. In this dissertation, sub-wavelength 3D nano-engineering is explored to create artificial optical materials with tunable optical properties. Block-copolymer templating coupled with a wet processing route was applied to realize 3D functional metal oxides with nanostructure features in the sub-50nm regime. Using this low-cost and scalable manufacturing method, high quality films of TiO2, SnO2, ZnO, and SiO2, with refractive indices continuously tunable in the range of 1.17 to 2.2, is demonstrated. These new optical materials open new opportunities in a wide range of applications. This dissertation explores applications for optical fiber sensing, solar cell anti-reflection technology, along with other suggested avenues for exploration. An expansion of the sensory capability of optical fiber type sensors to include the detection of chemical species, from low to high temperatures, is demonstrated. The merger of functional metal oxides with optical fiber is not well explored both theoretically and experimentally. Full wave simulations were performed that provide valuable insight in the design of these sensors along with experiments to identify the type of the sensory responses. Measurements performed using Optical Frequency Domain Reflectometry demonstrate the use of the developed sensors for the distributed type detection of hydrogen at very high temperatures, for applications in hydrogen driven Fuel Cells. With distributed sensing a single sensor can function as a linear combination of hundreds of sensor and can be used to analyze existing gradients across the sensor element. Optical anti-reflection technology can benefit substantially from the extensive broadening of the available refractive indices. Optimal anti-reflection coatings predicted by theory rely on continuous gradual changes in the refractive indices which are too difficult to manufacture conventionally, if at all. The use of the developed refractive index engineering scheme for the realization of low cost and practical, broad-band and omnidirectional anti-reflection coatings with an improved efficiency, is also demonstrated.
Pain, comorbidities, and clinical decision-making: conceptualization, development, and pilot testing of the Pain in Aging, Educational Assessment of Need instrument

Introduction Pain is highly prevalent in older adults and often contextualized by multiple clinical conditions (pain comorbidities). Pain comorbidities increase with age and this makes clinical decisions more complex. To address gaps in clinical training and geriatric pain management, we established the Pain in Aging—Educational Assessment of Need (PAEAN) project to appraise the impacts of medical and mental health conditions on clinical decision-making regarding older adults with pain. We here report development and pilot testing of the PAEAN survey instrument to assess clinician perspectives. Methods Mixed-methods approaches were used. Scoping review methodology was applied to appraise both research literature and selected Medicare-based data. A geographically and professionally diverse interprofessional advisory panel of experts in pain research, medical education, and geriatrics was formed to advise development of the list of pain comorbidities potentially impacting healthcare professional clinical decision-making. A survey instrument was developed, and pilot tested by diverse licensed healthcare practitioners from 2 institutions. Respondents were asked to rate agreement regarding clinical decision-making impact using a 5-point Likert scale. Items were scored for percent agreement. Results Scoping reviews indicated that pain conditions and comorbidities are prevalent in older adults but not universally recognized. We found no research literature directly guiding pain educators in designing pain education modules that mirror older adult clinical complexity. The interprofessional advisory panel identified 26 common clinical conditions for inclusion in the pilot PAEAN instrument. Conditions fell into three main categories: “major medical”, i.e., cardio-vascular-pulmonary; metabolic; and neuropsychiatric/age-related. The instrument was pilot tested by surveying clinically active healthcare providers, e.g., physicians, nurse practitioners, who all responded completely. Median survey completion time was less than 3 min. Conclusion This study, developing and pilot testing our “Pain in Aging—Educational Assessment of Need” (PAEAN) instrument, suggests that 1) many clinical conditions impact pain clinical decision-making, and 2) surveying healthcare practitioners about the impact of pain comorbidities on clinical decision-making for older adults is highly feasible. Given the challenges intrinsic to safe and effective clinical care of older adults with pain, and attendant risks, together with the paucity of existing relevant work, much more education and research are needed.