Miracle-dz/UniFAR-FTUs huggingface dataset:
Huaier Extract Induces Autophagic Cell Death by Inhibiting the mTOR/S6K Pathway in Breast Cancer Cells

Huaier extract is attracting increased attention due to its biological activities, including antitumor, anti-parasite and immunomodulatory effects. Here, we investigated the role of autophagy in Huaier-induced cytotoxicity in MDA-MB-231, MDA-MB-468 and MCF7 breast cancer cells. Huaier treatment inhibited cell viability in all three cell lines and induced various large membranous vacuoles in the cytoplasm. In addition, electron microscopy, MDC staining, accumulated expression of autophagy markers and flow cytometry revealed that Huaier extract triggered autophagy. Inhibition of autophagy attenuated Huaier-induced cell death. Furthermore, Huaier extract inhibited the mammalian target of the rapamycin (mTOR)/S6K pathway in breast cancer cells. After implanting MDA-MB-231 cells subcutaneously into the right flank of BALB/c nu/nu mice, Huaier extract induced autophagy and effectively inhibited xenograft tumor growth. This study is the first to show that Huaier-induced cytotoxicity is partially mediated through autophagic cell death in breast cancer cells through suppression of the mTOR/S6K pathway.
Understanding agency in interaction design materials

We draw on the concept of agency in order to understand the process of how design materials 'talk back' to designers. In so doing, we illustrate the various levels at which agency can emerge in the context of intensive short-time prototyping sessions. In HCI, it is often assumed that the designer is the agent that acts intentionally in the design process. Contrary to this, recent notions of agency provide a way of analysing the performative role of design materials as intra-actions between components within a given phenomenon, rather than as meanings merely ascribed by actions of designers. The notion of agency puts focus on the emerging properties of materials and how they actively contribute to the way that design activity unfolds. The analyses showed how interaction design is to a large extent driven by emergent characteristics of available materials. The results have implications for understanding material interactions and materiality in interaction design.
A digital calibration enhanced GSM/GPRS transmitter

This paper presents a GSM/GPRS transmitter which performance is enhanced by the proposed all digital self-calibration technique. Also, the non-ideal effects for realizing the technique including current mismatch, static phase error and VCO gain non-linearity in a conventional charge pump PLL can be self-diagnosed by the self-calibration. The measurement results shows 0.5 degree phase error and −68dBc ORFS for GMSK modulation, which prove that the accuracy of the loop gain calibration and VCO gain linearity is within 1%, and two times reduction compared to all digital and analog transmitters. The silicon prototype is implemented in 65nm process and with a 1.2V supply. The area overhead for the full custom design to enable the technique is only 0.005mm2.
Inconsistent sensor data detection/correction: Application to environmental systems

In this paper, a data detection/correction approach is proposed for a real environmental monitoring system, in order to provide a reliable dataset when sensor faults occur. This is the case of communication faults that may prevent the acquisition of a complete dataset, which is of paramount importance in order to successfully apply further system tasks such as fault diagnosis. Sensor detection/correction method presented here is based on the combined used of spatial and time series models. Spatial models take advantage of the physical relation between different variables emplaced in the system (temperature sensors here) while time series models take advantage of the temporal redundancy of the measured variables, by means of Holt-Winters models here. The proposed approach is successfully applied to the rock collapse forecasting system in the Torrioni di Rialba located in Lombardy (Italy).
A new symbiotic low mass X-ray binary system: 4U 1954+319

Aims. 4U 1954+319 was discovered 25 years ago, but only recently has a clear picture of its nature begun to emerge. We present for the first time a broad-band spectrum of the source and a detailed timing study using more than one year of monitoring data. Methods. The timing and spectral analysis was done using publicly available Swift, INTEGRAL, BeppoSAX, and RXTE/ASM data in the 0.7 to 150 keV energy band. Results. The source spectrum is described well by a highly absorbed (N H ∼ 10 23 cm -2 ) power law with a high-energy exponential cutoff around 15 keV. An additional black body component is needed below 3 keV to account for a soft excess. The derived ∼5 h periodicity, with a spin-up timescale of ∼25 years, could be identified as the neutron star spin period. The spectral and timing characteristics indicate that we are dealing both with the slowest established wind-accreting X-ray pulsar and with the second confirmed member of the emerging class dubbed "symbiotic low mass X-ray binaries" to host a neutron star.
Compressed sensing of Gauss-Markov random field with wireless sensor networks

We propose a scalable and energy efficient method for reconstructing a dasiasparsepsila Gauss-Markov random field that is observed by an array of sensors and described over wireless channels to a fusion center. The encoder is universal, i.e. invariant to the statistical model of the source and the channel, and is based on compressed sensing. The reconstruction algorithms exploit the a-priori statistical information about the field and the channel at the fusion center to yield a performance comparable to information theoretic bounds. Furthermore, by putting stringent constraints on the sensing matrix we avoid (or even eliminate) inter-sensor communication while suffering negligible degradation in performance.
Recognizing Anaphora Reference in Persian Sentences

Finding the reference of pronouns in a piece of text, which is a type of co-reference resolution, is an important task in discourse analysis and processing natural language texts.Pronoun reference is the noun that is replaced by the pronoun.In this paper, we propose a rule-based method for pronoun reference resolution in Persian texts. Our method exploits rules to recognize the reference of various types of pronouns in a 3-sentences interval. An automatic reference resolution system is developed based on the proposed method as the first pronoun reference resolution system for the Persian language. The experimental results show admissible accuracy in test cases. In this paper firstly we will describe some problems and challenges in detecting pronoun references and have an overview of related works in this field. In the next sections, after a brief description of the proposed method and the developed system, its features and architecture, we will discuss its components in detail. Then we will explain the experimental results and discuss further works to improve the system.
Electronic contracting in aircraft aftercare: a case study

Distributed systems comprised of autonomous self-interested entities require some sort of control mechanism to ensure the predictability of the interactions that drive them. This is certainly true in the aerospace domain, where manufacturers, suppliers and operators must coordinate their activities to maximise safety and profit, for example. To address this need, the notion of norms has been proposed which, when incorporated into formal electronic documents, allow for the specification and deployment of contract-driven systems. In this context, we describe the CONTRACT framework and architecture for exactly this purpose, and describe a concrete instantiation of this architecture as a prototype system applied to an aerospace aftercare scenario.
Bit error rate optimized time-domain equalizers for DMT systems

Time-domain equalizers (TEQs) have been applied extensively to shorten the channel impulse response, thus enhancing the transmission efficiency of multitone and multicarrier systems with cyclic prefix. Recent developments on TEQs have mainly been focused on minimizing the additive noise power, minimizing the ISI power or maximizing the total throughput. This paper takes a different approach by minimizing the detection error or bit error rate (BER) using the Chernoff bound, under a fixed ISI power of the equalized channel, simulation results showed that this approach achieves better performance in terms of the bit error rate when compared to the aforementioned approaches and is robust to channel noise and channel length. Both numerical and analytical solutions have been derived.
Exploring the Relational Responding Task (RRT) as a new measure of language attitudes

For decades, quantitative language attitude research has known little methodological innovation (Speelman et al. 2013). Yet, in the last few years, linguists have started to overcome this deadlock and have turned towards social psychology for new attitude measures. Especially the Implicit Association Test (IAT) has proven a successful new addition to the sociolinguist’s toolbox (e.g. Campbell-Kibler 2012; Pantos & Perkins 2012; Rosseel et al. 2015; Loudermilk 2015). Despite its relative success, the IAT has a number of limitations, such as the fact that it measures the association between two concepts (e.g. ‘I’ and ‘skinny’) without controlling for the relationship between those two concepts (e.g. ‘I am skinny’ vs. ‘I want to be skinny’). The Relational Responding Task (RRT), a novel implicit attitude measure recently developed by social psychologists (De Houwer et al. 2015), makes up for exactly that limitation by presenting participants with full propositions expressing beliefs rather than loose concepts.
Adaptive user interface of product recommendation based on eye-tracking

To reduce the intrusive interaction and workload for the product recommendations, we seek implicit methods to indicate users' preferences and recommend desirable products on the interface automatically. In this paper, we validate our approach with interactive genetic algorithm to compute fitness based on the eye-movement data metrics. And construct the adaptation strategies for content and layout design on the user interface. A digital camera recommendation prototype is proposed, and in the user study, we find that users can get interested products information with less physical effort and more satisfactions.
Biorobotics : Using robots to emulate and investigate agile animal locomotion

The graceful and agile movements of animals are difficult to analyze and emulate because locomotion is the result of a complex interplay of many components: the central and peripheral nervous systems, the musculoskeletal system, and the environment. The goals of biorobotics are to take inspiration from biological principles to design robots that match the agility of animals, and to use robots as scientific tools to investigate animal adaptive behavior. Used as physical models, biorobots contribute to hypothesis testing in fields such as hydrodynamics, biomechanics, neuroscience, and prosthetics. Their use may contribute to the design of prosthetic devices that more closely take human locomotion principles into account.
How Do Average Hours Worked Vary with Development? Cross-Country Evidence and Implications

How do average hours worked vary across the world income distribution? To answer this question, we build a new internationally comparable database of hours worked covering countries of all income levels. We document that average hours worked per adult are substantially higher in low-income countries than in high-income countries. This pattern holds for both men and women, for adults of all ages and education levels, and along both the extensive margin (employment rates) and intensive margin (hours per worker). Our results imply that labor productivity and welfare differences across countries are larger than suggested by differences in consumption per capita.
Type I Strings with F- and B-Flux

We present non-supersymmetric toroidal compactifications of type-I string theory with both constant background NSNS two-form flux and non-trivial magnetic flux on the various D9-branes. The non-vanishing B-flux admits four-dimensional models with three generations of chiral fermions in standard model like gauge groups. Additionally, we consider the orbifold 4/2, again with both kinds of background flux present, leading to non-supersymmetric as well as supersymmetric models in six dimensions. All models have T-dual descriptions as intersecting brane worlds.
IMPACT OF NASAL CONTINUOUS POSITIVE AIRWAY PRESSURE ON C-REACTIVE PROTEIN IN OBSTRUCTIVE SLEEP APNEA PATIENTS

Obstructive sleep apnea (OSA) has been increasingly linked with cardiovascular risk factors. Mechanisms such as increased sympathetic activity and endothelial dysfunction have been implicated. There are many factors which are responsible for the cardiovascular morbidity in OSA patients they are Obesity, C-reactive protein (CRP) and lipid profile. To study the impact of nasal continuous positive airway pressure (nCPAP) treatment on CRP levels in OSA patients. Average AHI of each subjects was; Mild OSA 11.02±2.62 Events / hour, Moderate OSA 22.48±3.90 Events / hour and Severe OSA 55.12±21.04 Events / hour. Out of 141 patients 110 were male (78.09%) and 31 were female (21.98%). The mean age of male and female in the study population was 52.22±5.12 and 49.11±4.12 years respectively. The average BMI for OSA patients was 31.48±6.8 kg / m 2 . A significant association was found between AHI and BMI (r=0.195 and p<0.02). Serum levels of CRP during baseline and after 6 months of nCPAP treatment were compared. The mean values of CRP of the study population were 8.45±4.30. 32 mg/l. Our result also revealed that there was a significant association between AHI and CRP (r=0.529, p<0.0001) BMI (r=0.220, p<0.05). There was a significant difference between CRP levels before and after six months of nCPAP treatment (p<0.05). The present study confirmed that elevated serum CRP levels were most commonly seen in obese obstructive sleep apneic patients. It also suggests that elevated CRP levels can be decreased by nCPAP treatment. INTRODUCTION: Obstructive sleep apnea (OSA) is a significant public health problem characterized by repetitive episodes of upper airway occlusion during sleep associated with sleep fragmentation, daytime hypersomnolence, and increased cardiovascular risk 1 . OSA has been increasingly linked with vascular risk factors. Mechanisms such as increased sympathetic activity and endothelial dysfunction have been implicated. There are many factors which are responsible for the cardiovascular morbidity in OSA patients they are Obesity, C-
The Role of Perceived Supervisor Support in the Interaction between Work-Family Conflict and Organizational Commitment: An Empirical Study

In this study, it is aimed at examining the effect of work-family/ family-work conflict on organizational commitment and the mediator effect of perceived supervisor support on this relationship. The data were collected with a survey from 342 participants working in public institutions and the data were analyzed via statistical programs. As a result of the structural equation modeling, the relationship between work-family conflict and organizational commitment was found to be statistically insignificant. On the other hand, family-work conflict was found to predict organizational commitment. In this context, it was found that there was a negative and significant relationship between family-work conflict and organizational commitment. Furthermore, the findings showed that perceived supervisor support had no role in the relationship between work-family conflict and organizational commitment. On the other hand, perceived supervisor support had partial mediation role in this relationship. Consequently, results indicated that work-family conflict decreased organizational commitment and by decreasing work-family conflict, perceived supervisor support increased organizational commitment with an indirect effect. In the study, results of the findings were discussed theoretically and various implications were presented for future studies.
A sound spatio-temporal Hoare logic for the verification of structured interactive programs with registers and voices

Interactive systems with registers and voices (shortly, rv- systems) are a model for interactive computing obtained closing register machines with respect to a space-time duality transformation ("voices" are the time-dual counterparts of "registers"). In the same vain, AGAPIA v0.1, a structured programming language for rv-systems, is the space- time dual closure of classical while programs (over a specific type of data). Typical AGAPIA programs describe open processes located at various sites and having their temporal windows of adequate reaction to the environment. The language naturally supports process migration, structured interaction, and deployment of components on heterogeneous machines. In this paper a sound Hoare-like spatio-temporal logic for the verifica- tion of AGAPIA v0.1 programs is introduced. As a case study, a formal verification proof of a popular distributed termination detection protocol is presented.
Enhancing cognitive radios with spatial statistics: From radio environment maps to topology engine

Radio environment maps are a promising architectural concept for storing environmental information for use in cognitive wireless networks. However, if not applied carefully their use can lead to large amounts of measurement data communicated over wireless links, causing substantial overhead. We propose enhancing the basic radio environment map concept by spatial statistics and probabilistic models, enabling applications to benefit from environment data while reducing overhead. In this paper we discuss the development of a topology engine, an agent in the CWN collecting and processing spatial information about the environment for storage in the REM. We discuss both technical and architectural issues in enabling such an approach, and outline some of the potential application scenarios for the topology engine.
Time‐Varying Functional Regression for Predicting Remaining Lifetime Distributions from Longitudinal Trajectories

Summary A recurring objective in longitudinal studies on aging and longevity has been the investigation of the relationship between age‐at‐death and current values of a longitudinal covariate trajectory that quantifies reproductive or other behavioral activity. We propose a novel technique for predicting age‐at‐death distributions for situations where an entire covariate history is included in the predictor. The predictor trajectories up to current time are represented by time‐varying functional principal component scores, which are continuously updated as time progresses and are considered to be time‐varying predictor variables that are entered into a class of time‐varying functional regression models that we propose. We demonstrate for biodemographic data how these methods can be applied to obtain predictions for age‐at‐death and estimates of remaining lifetime distributions, including estimates of quantiles and of prediction intervals for remaining lifetime. Estimates and predictions are obtained for individual subjects, based on their observed behavioral trajectories, and include a dimension‐reduction step that is implemented by projecting on a single index. The proposed techniques are illustrated with data on longitudinal daily egg‐laying for female medflies, predicting remaining lifetime and age‐at‐death distributions from individual event histories observed up to current time.
Endometrial safety of ospemifene: results of the phase 2/3 clinical development program

ObjectiveThis study aims to assess the endometrial safety of ospemifene based on phase 2/3 clinical trials of postmenopausal women with up to 52 weeks of exposure to ospemifene 60 mg/day versus placebo. MethodsEndometrial safety was evaluated in a development program of six randomized, double-blind, placebo-controlled, parallel-group studies of postmenopausal women aged between 40 and 80 years who had vulvar and vaginal atrophy. Participants were randomized 1:1 to ospemifene 60 mg/day or placebo in one 6-week trial and three 12-week trials; one of the 12-week trials had a 40-week extension study. In a separate 52-week trial, women were randomized 6:1 to ospemifene 60 mg/day or placebo. Endometrial safety was assessed by endometrial histology (biopsy), transvaginal ultrasound, and gynecologic examination. ResultsIn these trials, 1,242 women who received ospemifene 60 mg/day and 924 women who received placebo were evaluable for safety. Endometrial hyperplasia occurred in less than 1% of women treated with ospemifene; no endometrial cancer was reported. The mean (SD) increase in endometrial thickness among women treated with ospemifene was 0.51 (1.54) mm at 12 weeks, 0.56 (1.61) mm at 6 months, and 0.81 (1.54) mm at 12 months. Women who received placebo had a mean (SD) increase of 0.07 (1.23) mm at 12 months. ConclusionsThese clinical trial data indicate that up to 52 weeks of treatment with oral ospemifene 60 mg/day was safe for the endometrium. There was no increase in the incidence of endometrial cancer or hyperplasia among postmenopausal women treated with ospemifene compared with placebo.
Neurobehavioural effects of occupational exposure to cadmium: a cross sectional epidemiological study

BACKGROUND A patient with unexplained minor behavioural changes associated with an axonal sensorimotor polyneuropathy had a history of chronic occupational exposure to cadmium (Cd). Although animal studies have shown that Cd is a potent neurotoxicant, little is known about its toxicity for the human central nervous system. The aim of this study was to investigate the toxic potential of chronic occupational exposure to Cd on neurobehavioural functions. METHODS A cross sectional epidemiological study was conducted in a group of Cd workers and an age matched control group. Eighty nine adult men (42 exposed to Cd and 47 control workers) were given a blinded standardised examination that consisted of computer assisted neurobehavioural tests (neurobehavioural examination system), a validated questionnaire to assess neurotoxic complaints (neurotoxicity symptom checklist-60, NSC-60), and a standardised self administered questionnaire to detect complaints consistent with peripheral neuropathy and dysfunction of the autonomic nervous system. Historical and current data on biomonitoring of exposure to Cd, either the highest value of Cd in urine (CdU in μg Cd/g creatinine) of each Cd worker during work (CdUmax) or the current value (CdUcurrent) of each control, were available as well as data on microproteinuria. RESULTS Cd workers (CdUmax: mean (range), 12.6 (0.4–38.4)) performed worse than the controls (CdUcurrent: mean (range), 0.7 (0.1–2.0)) on visuomotor tasks, symbol digit substitution (p=0.008), and simple reaction time to direction (p=0.058) or location (p=0.042) of a stimulus. In multiple linear regression analysis, symbol digit substitution, simple direction reaction time test, and simple location reaction time test were significantly related to CdUmax, (β=0.35 ( p<0.001), β= 0.25 (p=0.012), and β=0.23 (p=0.021) respectively). More complaints consistent with peripheral neuropathy (p=0.004), complaints about equilibrium (p=0.015), and complaints about concentration ability (p=0.053) were found in the group exposed to Cd than in the control group, and these variables correlated positively with CdUmax (peripheral neuropathy: β=0.38, p<0.001; equilibrium: β=0.22, p=0.057; concentration ability: β=0.27, p=0.020). CONCLUSION Slowing of visuomotor functioning on neurobehavioural testing and increase in complaints consistent with peripheral neuropathy, complaints about equilibrium, and complaints about concentration ability were dose dependently associated with CdU. Age, exposure to other neurotoxicants, or status of renal function could not explain these findings. The present study also indicates that an excess of complaints may be detected in Cd workers before signs of microproteinuria induced by Cd occur.