Miracle-dz/UniFAR-FTUs huggingface dataset:
Burden of smoking in Lithuania: attributable mortality and years of potential life lost

Background High mortality rates from smoking related diseases are a significant public health issue in Lithuania. Study aims to estimate the number of smoking attributable deaths (SADs) and years of potential life lost in Lithuania in 2013. Methods Gender, age and disease specific mortality was calculated by applying the smoking attributable fractions (SAFs) to prevalence estimates of current and former smokers among Lithuanian adults aged ≥35 years that are based on the 2005 Lithuanian Health Interview Survey. Mortality data were obtained from the Institute of Hygiene Health Information Centre. Eight years lag was assumed between smoking rates and subsequent mortality. Sensitivity analysis was used to calculate SAFs applying smoking impact ratio method. Results In 2013, 13.9% of total mortality or 5771 deaths in Lithuania were attributable to smoking (5181 men and 590 women). The two leading causes of SADs were ischaemic heart disease (2861) and lung cancer (1054) that accounted for 67.8% of the smoking attributable mortality. In the same year, smoking accounted for 39 279 years of potential life lost (34 663 years for men and 4615 years for women). Conclusions Smoking causes a considerable mortality burden in Lithuania, killing nine times more males than females. Therefore reduction of smoking prevalence is an urgent public health need, which calls for implementation of effective and comprehensive tobacco control measures consistent with the World Health Organization Framework Convention on Tobacco Control Articles and Protocols and The Tobacco Products Directive.
Social Support, Health, and Health Care Access Among Latino Immigrant Men in an Emerging Community

Objective. To determine the association of social support with alcohol abuse, depression, and health care access among Latino immigrant men in an emerging Latino community (an area with a small yet growing Latino population). Methods. Cross-sectional baseline data of 140 men prior to a participatory male-to-male community health worker intervention among Latino immigrants were analyzed using logistic regression. Community health workers recruited community participants in Western Pennsylvania between 2011 and 2013. Results. Participants constituted a vulnerable group: 47% had not finished high school, 36% had moderate to severe depression, and 30% reported binge drinking in the past month. Health care access was low (insurance = 6%, usual source = 20%). In multivariable logistic regression high social support was associated with less binge drinking (odds ratio [OR] = 0.44; 95% confidence interval [CI] [0.20, 0.98]) and lower depression (OR = 0.22; 95% CI [0.09-0.54]). Social support was associated with having a dentist visit but not with other health care access measures. Conclusions. Results indicate that the role of social support seems important for drinking and depression but remains controversial for health care access. It raises the hypothesis that low social support may be one of the mechanisms for the increase in drinking that happens after immigration.
Integrated Affinity Biosensing Platforms on Screen-Printed Electrodes Electrografted with Diazonium Salts

Adequate selection of the electrode surface and the strategies for its modification to enable subsequent immobilization of biomolecules and/or nanomaterials integration play a major role in the performance of electrochemical affinity biosensors. Because of the simplicity, rapidity and versatility, electrografting using diazonium salt reduction is among the most currently used functionalization methods to provide the attachment of an organic layer to a conductive substrate. This particular chemistry has demonstrated to be a powerful tool to covalently immobilize in a stable and reproducible way a wide range of biomolecules or nanomaterials onto different electrode surfaces. Considering the great progress and interesting features arisen in the last years, this paper outlines the potential of diazonium chemistry to prepare single or multianalyte electrochemical affinity biosensors on screen-printed electrodes (SPEs) and points out the existing challenges and future directions in this field.
Effectiveness of a Technology-Based Injury Prevention Program for Enhancing Mothers’ Knowledge of Child Safety: Protocol for a Randomized Controlled Trial

Background Provision of anticipatory guidance for parents is recommended as an effective strategy to prevent injuries among young children. Technology-based anticipatory guidance has been suggested to reinforce the effectiveness of injury prevention and improve parents’ knowledge of child safety. Objective This study aims to examine the effectiveness of a technology-based injury prevention program with parental anticipatory guidance for enhancing mothers’ knowledge of child safety. Methods In this randomized controlled trial, 308 mothers will be recruited from the antenatal clinics and postnatal wards of two major public hospitals in Hong Kong. Participating mothers will be randomly assigned into intervention and control groups. Mothers in the intervention group will be given free access to a technology-based injury prevention program with anticipatory guidance, whereas mothers in the control group will be given a relevant booklet on parenting. The injury prevention program, available as a website or on a mobile app, includes behavioral components based on the Theory of Planned Behavior. The primary outcome measure will be the change in the mother’s knowledge of child safety. The secondary outcome measures will be age-appropriate domestic safety knowledge, attitudes, intentions, perceived behavioral control, and self-reported behavior related to home safety practice. We will also determine dose-response relationships between the outcome measures and the website and mobile app usage. Results Enrolment of participants will begin in October 2016. Results are expected by June 2018. Conclusions Parents will be able to easily access the domestic injury prevention website to find information regarding child injury prevention. It is anticipated that the technology-based intervention will help parents improve their knowledge of child safety and raise their awareness about the consequences of domestic injuries and the importance of prevention. Trial Registration Clinicaltrials.gov Clinicaltrials.gov NCT02835768; http://clinicaltrials.gov/ct2/show/NCT02835768 (Archived by WebCite at http://www.webcitation/6lbXYM6b9)
Sampled‐data poles, zeros, and modeling for current‐mode control

Exact and approximate sampled‐data models in closed forms are derived for switching DC–DC converters under peak/valley current‐mode control. The corresponding sampled‐data poles and zeros in closed forms are also derived. The location and stability conditions of the poles and zeros, boundary conditions of subharmonic instability, and nulling of the audio‐susceptibility are also derived. It is proved that the stable operating range of the source voltage is linearly proportional to the ramp slope. The sampled‐data models agree with previous experiment results and accurately predict the subharmonic instability. The different view from the sampled‐data model about the number and stability (minimum phase) of pole and zero does not necessarily invalidate the traditional continuous‐time averaged model. However, this different view gives better prediction about converter dynamics and is useful for the analog or digital controller design for DC–DC converters. Copyright © 2011 John Wiley & Sons, Ltd.
Predator, Pet Lesbian, or Just The Nanny? LGBTQ Parents of Children With Disabilities Describe Categorization

ABSTRACT How are lesbian/gay/bisexual/trans/queer (LGBTQ) parents of children with disabilities categorized by service providers, and how do parents anticipate, interpret, and respond to such categorizations? This intersectional study investigated the experiences of LGBTQ parents of children with disabilities with service providers in Toronto, Canada. Parents described pressures to “fit” into providers’ limited understanding of family. Some parents described facing overt discrimination, including one parent who was seen as a possible sexual predator. Some described being perceived as representatives of “diversity” for organizations, or “pet lesbians” in the words of one couple. Others described being misread as a non-parent, as in “just the nanny,” particularly in conjunction with their racial minority status. Parents described how their experiences of being “outside the mainstream” helped them challenge systems and normative beliefs. Findings suggest that a context of scarce disability resources shapes parents’ experiences of how LGBTQ identity comes to matter.
Numerical and experimental study of the influence of multiple scattering on surface waves dispersion curves

The diagnosis of structures and the evaluation of their residual life is an important issue for civil engineering. Surface waves offer an effective mean for retrieving in a non invasive manner mechanical intrinsic properties of material as a function of depth. In most cases which deal with cover-concrete non destructive evaluation, the assumption of homogeneous layers can be debatable when the aggregates represent approximately 50% in weight and have sizes comparable to the expected depth resolution. Indeed, multiple scattering has an impact on the surface wave effective phase velocity dispersion curve when the incident wavelengths are similar to the radius of inclusions. Multiple scattering theories, such as ISA model, describes the propagation of coherent bulk waves propagating in infinite heterogeneous medium. ISA is known to be theoretically available for a dilute medium and weak mechanical contrast between the inclusions and the matrix. In a In order to validate the assumption that Rayleigh wave velocities can be computed with the effective compression and shear waves velocities, an experimental and numerical approach have been developed. We study the elastic wave propagation in 300mm x 150mm x 80mm heterogeneous blocks made of mass casting polyurethane resin containing 12% of randomly distributed circular aluminum inclusions having a radius of 2.5mm. The ultrasonic measurements are performed with a laser interferometer. The source frequency content lies in the range of 30-300 kHz. According to surface wave properties, the investigation depth in our reduced scale models corresponds to cover-concrete thickness (typically 3-5 cm). The experimental dispersion curves are compared with that of numerical simulations computed by a code based on the Spectral Element Method. The effective phase velocities are compared with the predictions obtained with the ISA model.
Incomplete CSI Based Resource Optimization in SWIPT Enabled Heterogeneous Networks: A Non-Cooperative Game Theoretic Approach

Heterogeneous small cell network with energy harvesting is a promising technique in the next generation mobile communications. However, the cross tier and co-tier co-channel interference can be severe due to the spectrum sharing in inter tier and intra tier of a heterogeneous small cell network. This paper investigates the problem of power allocation and subchannel assignment with the consideration of cross tier/co-tier interference mitigation, energy harvesting, and incomplete channel state information. The power allocation problem in heterogeneous small cell network is modeled as a non-cooperative game by introducing a time-varying cross tier/co-tier interference pricing with simultaneous wireless information and power transfer. Subchannel allocation is modeled as a non-cooperative potential game by minimizing the total interferences experienced by users on each subchannel. Iterative algorithms of power optimization and subchannel allocation are proposed to obtain the Nash equilibrium points. Simulation results are presented to verify the effectiveness of the proposed algorithms in the heterogeneous small cell network.
Matrix Metalloproteinase Activity Correlates With Uterine Myoma Volume Reduction After Ulipristal Acetate Treatment

Context Ulipristal acetate (UPA), a selective progesterone receptor modulator, clinically reduces uterine myoma size in 80% of cases. However, the molecular mechanism of action is still poorly understood, as is the reason why 20% of myomas do not respond to treatment. Objective To elucidate whether matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are associated with myoma volume shrinkage after UPA therapy. Design Prospective study. Setting Academic research unit of a university hospital. Patients Uterine biopsies were obtained from 59 patients with symptomatic myomas undergoing myomectomy, 45 of whom were treated preoperatively with either one or greater than or equal to two, 3-month courses of UPA and 14 not given any hormone therapy to serve as controls. Myoma volume was individually monitored during UPA therapy to determine any substantial clinical response (defined as a reduction in volume of >25%). Three groups were established based on the response to treatment: responsive (R) after one course (n = 12); R after two to four courses (n = 15); and nonresponsive (NR; n = 18). Interventions UPA treatment given as preoperative management for symptomatic myomas. Main Outcome Measures MMP and TIMP expression assessed by zymography and immunohistochemistry. Results Compared with controls and NR myomas, responders showed significantly higher expression levels for MMP-1 (P < 0.0001) and MMP-2 (P = 0.009) and significantly lower expression levels for TIMP-1 (P = 0.040). Conclusions The correlation found between MMP expression and volume fold change supports the notion that MMPs play a key role in UPA-induced myoma shrinkage.
Tissue characterization by T1 and T2 mapping cardiovascular magnetic resonance imaging to monitor myocardial inflammation in healing myocarditis

Aims Monitoring disease activity in myocarditis is important for tailored therapeutic strategies. This study evaluated the ability of T1 and T2 mapping cardiovascular magnetic resonance (CMR) to monitor the course of myocardial inflammation in healing myocarditis. Methods and Results Forty-eight patients with strictly defined acute myocarditis underwent CMR at 1.5 T in the acute stage, at 3-months (n = 39), and at 12-months follow-up (FU) (n = 21). Normal values were obtained in a control group of 27 healthy subjects. The CMR protocol included standard (‘Lake-Louise’) sequences as well as T1 (modified Look-Locker inversion recovery sequence, MOLLI) and T2 (gradient- and spin-echo sequence, GraSE) mapping. T1, T2, and extracellular volume (ECV) maps were generated using an OsiriX plug-in. Native myocardial T1, T2, and ECV values were increased in the acute stage, but declined with healing of myocarditis. The performances of global native T1 and T2 to differentiate acute from healed myocarditis stages were significantly better compared with all other global CMR parameters with AUCs of 0.85 (95% CI, 0.76–0.94) and 0.83 (95% CI, 0.73–0.93). Furthermore, regional native T1 and T2 in myocarditis lesions provided AUCs of 0.97 (95% CI, 0.93–1.02) and 0.93 (95% CI, 0.85–1.01), which were significantly superior to any other global or regional CMR parameter. Conclusion Healing of myocarditis can be monitored by native myocardial T1 and T2 measurements without the need for contrast media. Both native myocardial T1 and T2 provide an excellent performance for assessing the stage of myocarditis by CMR.
Analysis of Strategy for Achieving Zero-Current Switching in Full-Bridge Converters

Conventional zero-voltage and zero-current-switching (ZVZCS) full-bridge converters are widely used because they can realize zero-voltage switching (ZVS) for the leading leg and zero-current switching (ZCS) for the lagging leg. However, the large turn-off loss of the leading leg is still unacceptable in high-voltage high-power applications where insulated-gate bipolar transistors (IGBTs) with current tailing are employed. Hence, it is preferable to achieve ZCS for all IGBTs of full-bridge converters. This paper analyzes the ZCS conditions for pulsewidth modulated (PWM) full-bridge converters and proposes a general strategy for achieving ZCS for main switches, including the control strategy and design method of the topology. Based on this theory, a novel ZCS PWM full-bridge converter with simple auxiliary circuit is derived and tested. It can achieve ZCS not only for the main switches of full-bridge converter, but for the auxiliary switch as well, and obtain high efficiency. The operation principle of the proposed ZCS PWM full-bridge converter and the design procedure are presented. The experimental results of a 600 V/2.5 kW prototype are also included to verify the theoretical analysis.
Menopausal symptom clusters and their correlates in women with and without a history of breast cancer: a pooled data analysis from the Women's Wellness Research Program

Objectives: This analysis examined climacteric symptoms clusters in women with and without breast cancer, and explored how sociodemographic, health, and modifiable lifestyle factors predicted symptom clusters. Methods: This pooled analysis of four Women's Wellness Research Program (WWRP) studies comprised individual-level data from 969 Australian women aged 40 to 63 years, 293 of whom had been previously treated for breast cancer and 678 without a breast cancer history. Climacteric symptoms, menopausal status, sociodemographic characteristics, and health and lifestyle factors were assessed. Principal component analysis was used to determine symptom clusters for each group separately before linear regression with backwards selection was used to identify the significant correlates of the identified clusters. Results: Women with a history of breast cancer reported more sleep disturbance (P < 0.01), difficulty concentrating (P < 0.01), muscular/joint pain (P < 0.01), crying (P < 0.01) and irritability (P < 0.01), and vasomotor symptoms (P < 0.01) than women from the noncancer group. Principal component analysis with quartimax rotation revealed two distinct solutions explaining 60.9% and 57.6% of the variance in the groups, respectively. For both groups, symptom clusters were increased among those with unhealthy lifestyle behaviors (and chemotherapy among the after cancer group, P < 0.05 for all), though to a lesser extent in the breast cancer group. Conclusions: In this study, women after treatment for breast cancer reported a broad range of bothersome climacteric symptoms. Similar symptom clusters were also noted for women with and without a history of breast cancer, though correlates differed across groups, and might reflect different underlying etiologies.
Perceptions of Menthol Cigarettes Among Twitter Users: Content and Sentiment Analysis

Background Menthol cigarettes are used disproportionately by African American, female, and adolescent smokers. Twitter is also used disproportionately by minority and younger populations, providing a unique window into conversations reflecting social norms, behavioral intentions, and sentiment toward menthol cigarettes. Objective Our purpose was to identify the content and frequency of conversations about menthol cigarettes, including themes, populations, user smoking status, other tobacco or substances, tweet characteristics, and sentiment. We also examined differences in menthol cigarette sentiment by prevalent categories, which allowed us to assess potential perceptions, misperceptions, and social norms about menthol cigarettes on Twitter. This approach can inform communication about these products, particularly to subgroups who are at risk for menthol cigarette use. Methods Through a combination of human and machine classification, we identified 94,627 menthol cigarette-relevant tweets from February 1, 2012 to January 31, 2013 (1 year) from over 47 million tobacco-related messages gathered prospectively from the Twitter Firehose of all public tweets and metadata. Then, 4 human coders evaluated a random sample of 7000 tweets for categories, including sentiment toward menthol cigarettes. Results We found that 47.98% (3194/6657) of tweets expressed positive sentiment, while 40.26% (2680/6657) were negative toward menthol cigarettes. The majority of tweets by likely smokers (2653/4038, 65.70%) expressed positive sentiment, while 91.2% (320/351) of nonsmokers and 71.7% (91/127) of former smokers indicated negative views. Positive views toward menthol cigarettes were predominant in tweets that discussed addiction or craving, marijuana, smoking, taste or sensation, song lyrics, and tobacco industry or marketing or tweets that were commercial in nature. Negative views toward menthol were more common in tweets about smoking cessation, health, African Americans, women, and children and adolescents—largely due to expression of negative stereotypes associated with these groups’ use of menthol cigarettes. Conclusions Examinations of public opinions toward menthol cigarettes through social media can help to inform the framing of public communication about menthol cigarettes, particularly in light of potential regulation by the European Union, US Food and Drug Administration, other jurisdictions, and localities.
eMAP:CKD: electronic diagnosis and management assistance to primary care in chronic kidney disease

Abstract Background The increasing burden of chronic kidney disease (CKD) underpins the importance for improved early detection and management programs in primary care to delay disease progression and reduce mortality rates. eMAP:CKD is a pilot program for primary care aimed at addressing the gap between current and best practice care for CKD. Methods Customized software programs were developed to integrate with primary care electronic health records (EHRs), allowing real-time prompting for CKD risk factor identification, testing, diagnosis and management according to Kidney Health Australia's (KHA) best practice recommendations. Primary care practices also received support from a visiting CKD nurse and education modules. Patient data were analyzed at baseline (150 910 patients) and at 15 months (175 917 patients) following the implementation of the program across 21 primary care practices. Results There was improvement in CKD risk factor recognition (29.40 versus 33.84%; P < 0.001) and more complete kidney health tests were performed (3.20 versus 4.30%; P < 0.001). There were more CKD diagnoses entered into the EHR (0.48 versus 1.55%; P < 0.001) and more patients achieved KHA's recommended management targets (P < 0.001). Conclusion The eMAP:CKD program has shown an improvement in identification of patients at risk of CKD, appropriate testing and management of these patients, as well as increased documentation of CKD diagnosis entered into the EHRs. We have demonstrated efficacy in overcoming the verified gap between current and best practice in primary care. The success of the pilot program has encouraging implications for use across the primary care community as a whole.