Miracle-dz/UniFAR-FTUs huggingface dataset:
Transparency, Political Polarization, and Political Budget Cycles in OECD Countries

We investigate the effects of fiscal transparency and political polarization on the prevalence of electoral cycles in fiscal balance. While some recent political economy literature on electoral cycles identifies such cycles mainly in weak and recent democracies, in contrast we show, conditioning on a new index of institutional fiscal transparency, that electoral cycles in fiscal balance are a feature of many advanced industrialized economies. Using a sample of 19 OECD countries in the 1990s, we identify a persistent pattern of electoral cycles in low(er) transparency countries, while no such cycles can be observed in high(er) transparency countries. Furthermore, we find, in accordance with recent theory, that electoral cycles are larger in politically more polarized countries.
Sexual and natural selection in the evolution of extended phenotypes: the use of green nesting material in starlings

Although sexual selection is typically considered the predominant force driving the evolution of ritualized sexual behaviours, natural selection may also play an important and often underappreciated role. The use of green aromatic plants among nesting birds has been interpreted as a component of extended phenotype that evolved either via natural selection due to potential sanitary functions or via sexual selection as a signal of male attractiveness. Here, we compared both hypotheses using comparative methods in starlings, a group where this behaviour is widespread. We found that the use of green plants was positively related to male‐biased size dimorphism and that it was most likely to occur among cavity‐nesting species. These results suggest that this behaviour is likely favoured by sexual selection, but also related to its sanitary use in response to higher parasite loads in cavities. We speculate that the use of green plants in starlings may be facilitated by cavity nesting and was subsequently co‐opted as a sexual signal by males. Our results represent an example of how an extended phenotypic component of males becomes sexually selected by females. Thus, both natural selection and sexual selection are necessary to fully understand the evolution of ritualized behaviours involved in courtship.
Macroscopic bound entanglement in thermal graph states

We address the presence of bound entanglement in strongly interacting spin systems at thermal equilibrium. In particular, we consider thermal graph states composed of an arbitrary number of particles. We show that for a certain range of temperatures no entanglement can be extracted by means of local operations and classical communication, even though the system is still entangled. This is found by harnessing the independence of the entanglement in some bipartitions of such states with the system's size. Specific examples for one- and two-dimensional systems are given. Our results thus prove the existence of thermal bound entanglement in an arbitrary large spin system with finite-range local interactions.
Increasing Our Understanding of the Health-Income Gradient in Children

There have been numerous attempts to both document the income-health gradient in children and to understand the nature of the tie. In this paper, we review and summarize existing studies, and then use a unique school-based panel data set from the USA to attempt to further our understanding of the relationship. The long duration (5 observations, 9 years) allows us to add to the understanding of the pattern of the tie, through our ability to test for changes in health status and multiple measures of income, and the school-based nature of the data allow us to add community socioeconomic status to the model. Increasing understanding of the income-health gradient has clear policy implications in terms of effective targeting of interventions to decrease the gradient and hence decrease health disparities among children.
Comparison of Synthetic and Natural Organic Polymers as Flocculant for Textile Wastewater Treatment

Performance of synthetic organic polymer (polyacrylamide) and natural organic polymers (pectin) as flocculant in coagulation-flocculation treatment will be assessed. Analysis of functional group of organic polymer was done by Fourier Transform Infrared Spectroscopy - Attenuated Total Reflectance (FTIR-ATR). Response Surface Methodology - Central Composite Design (RSM-CCD) was used to evaluate the interaction effects of pH, coagulant dose and flocculant dose. The experiment was conducted in lab scale of 500mL of sample textile wastewater with six paddle of conventional jar test. Trimmed Spearman-Karber method has been used to estimate median lethal concentration (LC ) values and their confidence intervals. The result shows 50 polyacrylamide added in the treatment was the best at optimum pH 5, coagulant dose at 275 mg/ L and flocculant dose at 35 mg/ L with 88 and 80% removal. In contrast, additions of natural organic flocculant only manage to remove 54.2 and 67 % at the optimum pH 5, coagulant and flocculant dosage at 427.4 and 21.9 mg/ L respectively. However, polyacrylamide treatment claimed to be more toxic based on lethal concentration (LC ) 50 at 17 % compare to natural organic flocculant at 34%.
Repetitive Neonatal Erythropoietin and Melatonin Combinatorial Treatment Provides Sustained Repair of Functional Deficits in a Rat Model of Cerebral Palsy

Cerebral palsy (CP) is the leading cause of motor impairment for children worldwide and results from perinatal brain injury (PBI). To test novel therapeutics to mitigate deficits from PBI, we developed a rat model of extreme preterm birth (<28 weeks of gestation) that mimics dual intrauterine injury from placental underperfusion and chorioamnionitis. We hypothesized that a sustained postnatal treatment regimen that combines the endogenous neuroreparative agents erythropoietin (EPO) and melatonin (MLT) would mitigate molecular, sensorimotor, and cognitive abnormalities in adults rats following prenatal injury. On embryonic day 18 (E18), a laparotomy was performed in pregnant Sprague–Dawley rats. Uterine artery occlusion was performed for 60 min to induce placental insufficiency via transient systemic hypoxia-ischemia, followed by intra-amniotic injections of lipopolysaccharide, and laparotomy closure. On postnatal day 1 (P1), approximately equivalent to 30 weeks of gestation, injured rats were randomized to an extended EPO + MLT treatment regimen, or vehicle (sterile saline) from P1 to P10. Behavioral assays were performed along an extended developmental time course (n = 6–29). Open field testing shows injured rats exhibit hypermobility and disinhibition and that combined neonatal EPO + MLT treatment repairs disinhibition in injured rats, while EPO alone does not. Furthermore, EPO + MLT normalizes hindlimb deficits, including reduced paw area and paw pressure at peak stance, and elevated percent shared stance after prenatal injury. Injured rats had fewer social interactions than shams, and EPO + MLT normalized social drive. Touchscreen operant chamber testing of visual discrimination and reversal shows that EPO + MLT at least partially normalizes theses complex cognitive tasks. Together, these data indicate EPO + MLT can potentially repair multiple sensorimotor, cognitive, and behavioral realms following PBI, using highly translatable and sophisticated developmental testing platforms.
Targets and Mechanisms Associated with Protection from Severe Plasmodium falciparum Malaria in Kenyan Children

ABSTRACT Severe malaria (SM) is a life-threatening complication of infection with Plasmodium falciparum. Epidemiological observations have long indicated that immunity against SM is acquired relatively rapidly, but prospective studies to investigate its immunological basis are logistically challenging and have rarely been undertaken. We investigated the merozoite targets and antibody-mediated mechanisms associated with protection against SM in Kenyan children aged 0 to 2 years. We designed a unique prospective matched case-control study of well-characterized SM clinical phenotypes nested within a longitudinal birth cohort of children (n = 5,949) monitored over the first 2 years of life. We quantified immunological parameters in sera collected before the SM event in cases and their individually matched controls to evaluate the prospective odds of developing SM in the first 2 years of life. Anti-AMA1 antibodies were associated with a significant reduction in the odds of developing SM (odds ratio [OR] = 0.37; 95% confidence interval [CI] = 0.15 to 0.90; P = 0.029) after adjustment for responses to all other merozoite antigens tested, while those against MSP-2, MSP-3, Plasmodium falciparum Rh2 [PfRh2], MSP-119, and the infected red blood cell surface antigens were not. The combined ability of total IgG to inhibit parasite growth and mediate the release of reactive oxygen species from neutrophils was associated with a marked reduction in the odds of developing SM (OR = 0.07; 95% CI = 0.006 to 0.82; P = 0.03). Assays of these two functional mechanisms were poorly correlated (Spearman rank correlation coefficient [rs ] = 0.12; P = 0.07). Our data provide epidemiological evidence that multiple antibody-dependent mechanisms contribute to protective immunity via distinct targets whose identification could accelerate the development of vaccines to protect against SM.
An organic–metal–inorganic three-component nanojunction array: design, construction and its reversible diode-like resistive electrical switching behavior

A reversible diode-like resistive electrical switching composite material, an AgTCNQF4–AgNPs–TiO2 organic–metal–inorganic hetero-nanojunction array, has been successfully prepared on a fluorine-doped tin oxide (FTO) glass slide. These AgTCNQF4–AgNPs–TiO2 nanojunctions show obvious absorption bands in the visible to near-infrared region, which are attributed to interfacial charge transfer from TiO2 to AgTCNQF4. Moreover, the local electrical properties of these AgTCNQF4–AgNPs–TiO2 nanojunctions have been tested in a device configuration of Au-tip/AgTCNQF4–AgNPs–TiO2/FTO and the measured results reveal that these AgTCNQF4–AgNPs–TiO2 nanojunctions possess many applicable functions involving the switchable diode effect, reversible electrical switching and memory behavior.
What Butler Saw: Cross-Dressing and Spectatorship in Seventeenth-Century France

At the same time, Butler’s theories are open to a number of criticisms,whichIintendtointerrogateherebyreassessingherthought in the light of three seventeenth-century poems about cross-dressing. Above all, Butler’s theories are profoundly ahistorical; although not in itself a criticism, this does mean that she can tell us little about the particular ways in which sex and gender might be constructed in different historical or geographical contexts. My own research, for example, has demonstrated that the significance of cross-dressing can rarely be reduced to a matter of gender alone; indeed, cross-dressing can even become reified as a third term, quasi-independent of the two conventional genders. 2 Yet these problems of ahistoricity can be most helpfully explored through a second lacuna in Butler’s thought: the role of the spectator. Crucially, as Nicholas Hammond stresses, Butler’s exploration of cross-dressing ‘does not examine the importance of the body as
Inducible Knockdown of Endothelial Protein Tyrosine Phosphatase-1B Promotes Neointima Formation in Obese Mice by Enhancing Endothelial Senescence.

AIMS Protein tyrosine phosphatase-1B (PTP1B) is a negative regulator of receptor tyrosine kinase signaling. In this study, we determined the importance of PTP1B expressed in endothelial cells for the vascular response to arterial injury in obesity. RESULTS Morphometric analysis of vascular lesions generated by 10% ferric chloride (FeCl3) revealed that tamoxifen-inducible endothelial PTP1B deletion (Tie2.ERT2-Cre × PTP1Bfl/fl; End.PTP1B knockout, KO) significantly increased neointima formation, and reduced numbers of (endothelial lectin-positive) luminal cells in End.PTP1B-KO mice suggested impaired lesion re-endothelialization. Significantly higher numbers of proliferating cell nuclear antigen (PCNA)-positive proliferating cells as well as smooth muscle actin (SMA)-positive or vascular cell adhesion molecule-1 (VCAM1)-positive activated smooth muscle cells or vimentin-positive myofibroblasts were detected in neointimal lesions of End.PTP1B-KO mice, whereas F4/80-positive macrophage numbers did not differ. Activated receptor tyrosine kinase and transforming growth factor-beta (TGFβ) signaling and oxidative stress markers were also significantly more abundant in End.PTP1B-KO mouse lesions. Genetic knockdown or pharmacological inhibition of PTP1B in endothelial cells resulted in increased expression of caveolin-1 and oxidative stress, and distinct morphological changes, elevated numbers of senescence-associated β-galactosidase-positive cells, and increased expression of tumor suppressor protein 53 (p53) or the cell cycle inhibitor cyclin-dependent kinase inhibitor-2A (p16INK4A) suggested senescence, all of which could be attenuated by small interfering RNA (siRNA)-mediated downregulation of caveolin-1. In vitro, senescence could be prevented and impaired re-endothelialization restored by preincubation with the antioxidant Trolox. INNOVATION Our results reveal a previously unknown role of PTP1B in endothelial cells and provide mechanistic insights how PTP1B deletion or inhibition may promote endothelial senescence. CONCLUSION Absence of PTP1B in endothelial cells impairs re-endothelialization, and the failure to induce smooth muscle cell quiescence or to protect from circulating growth factors may result in neointimal hyperplasia.
Harmonic template neurons in primate auditory cortex underlying complex sound processing

Significance Harmonicity is a fundamental element of music, speech, and animal vocalizations. How the brain extracts harmonic structures embedded in complex sounds remains largely unknown. We have discovered a unique population of harmonic template neurons in the core region of auditory cortex of marmosets, a highly vocal primate species. Responses of these neurons show nonlinear facilitation to harmonic complex sounds over inharmonic sounds and selectivity for particular harmonic structures. Such neuronal selectivity may form the basis of harmonic processing by the brain and has important implications for music and speech processing. Harmonicity is a fundamental element of music, speech, and animal vocalizations. How the auditory system extracts harmonic structures embedded in complex sounds and uses them to form a coherent unitary entity is not fully understood. Despite the prevalence of sounds rich in harmonic structures in our everyday hearing environment, it has remained largely unknown what neural mechanisms are used by the primate auditory cortex to extract these biologically important acoustic structures. In this study, we discovered a unique class of harmonic template neurons in the core region of auditory cortex of a highly vocal New World primate, the common marmoset (Callithrix jacchus), across the entire hearing frequency range. Marmosets have a rich vocal repertoire and a similar hearing range to that of humans. Responses of these neurons show nonlinear facilitation to harmonic complex sounds over inharmonic sounds, selectivity for particular harmonic structures beyond two-tone combinations, and sensitivity to harmonic number and spectral regularity. Our findings suggest that the harmonic template neurons in auditory cortex may play an important role in processing sounds with harmonic structures, such as animal vocalizations, human speech, and music.
Furan- and Thiophene-2-Carbonyl Amino Acid Derivatives Activate Hypoxia-Inducible Factor via Inhibition of Factor Inhibiting Hypoxia-Inducible Factor-1

Induction of a series of anti-hypoxic proteins protects cells during exposure to hypoxic conditions. Hypoxia-inducible factor-α (HIF-α) is a major transcription factor that orchestrates this protective effect. To activate HIF exogenously, without exposing cells to hypoxic conditions, many small-molecule inhibitors targeting prolyl hydroxylase domain-containing protein have been developed. In addition, suppression of factor inhibiting HIF-1 (FIH-1) has also been shown to have the potential to activate HIF-α. However, few small-molecule inhibitors of FIH-1 have been developed. In this study, we synthesized a series of furan- and thiophene-2-carbonyl amino acid derivatives having the potential to inhibit FIH-1. The inhibitory activities of these compounds were evaluated in SK-N-BE(2)c cells by measuring HIF response element (HRE) promoter activity. Several furan- and thiophene-2-carbonyl amino acid derivatives inhibited FIH-1 based on correlations among the docking score of the FIH-1 active site, the chemical structure of the compounds, and biological HIF-α/HRE transcriptional activity.
Adaptive data burst assembly in OBS networks

To perform an Optical Burst Switching (OBS) network, a lot of challenges are faced that have to be solved. The edge node has to manage burst offset time and burst assembly technique. The core node has to reserve resources to send the data burst, schedule the control packet and data burst and contention resolution strategy. In this paper, we discuss the burst assembly mechanisms and their disadvantages which we will overcome using a new and simple algorithm for data burst generation which relies on changing some characteristics in queuing model in OBS network by taking into consideration the presences of Quality of Service (QoS) for multiple data priorities. The OBS network simulation using our algorithm shows that it adaptively changes the data burst size according to the offered load. So, it can offer high data burst utilization, limits the maximum end to end delay and reduces burst drop rate for high priority packets.
POLLEN FLORA OF PAKISTAN – LXVIII

Pollen morphology 20 species of the family Alliaceae from Pakistan has been examined by light and scanning electron microscope. Pollen grains are usually bilateral, hetropolar mostly boat shaped, sexine thicker tor thinner than nexine. Tectal surface is mostly rugulate foveolate or subpsilate rarely reticulate. On the basis of apertural types 3 distinct pollen types are recognized, viz., Allium fedtschenkoanum –type, Allium grifthianum-type and Allium roylei-type.
Analysis on influencing factors of abnormal renal function in elderly patients with type 2 diabetes mellitus.

BACKGROUND To investigate the related influencing factors of abnormal renal function in elderly in patients with type 2 diabetes mellitus (T2DM) and their clinical significance. METHODS The clinical data of elderly T2DM patients hospitalized in Beijing Luhe Hospital from January 2013 to June2016 were retrospectively analyzed. According to their glomerular filtration rate (GFR) levels, these patients were divided into GFR ≥90 mL/min/1.73m2 group (Group A), GFR =60-90 mL/min/1.73m2 group (Group B), and GFR <60 mL/min/1.73m2 group (Group C, i.e., abnormal renal function group). Clinical and laboratory indicators were compared among each group. RESULTS A total of 614 elderly T2DM patients were collected and divided into Group A (n=186), Group B (n=280) and Group C (n=148, 24.10%). Among them, patients clinically diagnosed with diabetic nephropathy (DN) accounted for 13.68%, and those complicated with high blood pressure (HBP) accounted for 61.40%. In Group C, DN accounted for only 29.73%. In elderly T2DM patients, HBP course, systolic blood pressure (SBP), diastolic blood pressure (DBP), 2h postprandial blood glucose (2hPBG), serum total cholesterol (TC) and blood uric acid (BUA) were independent influencing factors associated with abnormal renal function, among which HBP had a more significant impact on abnormal renal function. With the increase of blood pressure (BP) level, the extension in the course of DM, the increase in urinary albumin/creatinine (Alb/Cr) and the decrease in GFR, the incidence rate of abnormal renal function was increased. CONCLUSIONS HBP course, SBP, DBP, 2hPBG, TC and BUA are independent risk factors for abnormal renal function in elderly patients with T2DM. Well-controlled BP and blood glucose are protective factors, and a comprehensive treatment targeting to the above influencing factors has important clinical significance in preventing and delaying the occurrence and development of abnormal renal function.
Use of Standard Guidelines for Department of Medicine Summary Letters

ABSTRACT Phenomenon: Fourth-year medical students obtain Department of Medicine (DOM) letters (“Chair” letters) to support their residency applications. Writing and interpreting DOM letters are challenging. There is heterogeneity in the letters that makes it difficult to both write and read these letters. Approach: The purpose of this study is to determine the value of new guidelines developed by a task force of clerkship directors and program directors in internal medicine and assess the implementation of these guidelines. The Clerkship Directors in Internal Medicine performed a cross-sectional survey of internal medicine clerkship directors at U.S. and Canadian medical schools in 2014. In addition, the primary author's institution reviewed 1,347 DOM letters between 2012 and 2014 to assess the implementation of these guidelines. Findings: The survey response rate was 78%. DOM letter writers reported the guidelines were better, easier to implement, and more compatible with the purpose of DOM letters than previously. Most letter readers reported that letters using the guidelines were more credible. Writers of DOM letters in lower academic ranks rated the letters with guidelines higher in several domains than those in higher academic ranks. Readers of DOM letters in higher academic ranks rated the letters with guidelines higher in several domains than those in lower academic ranks. In the DOM letters examined, the odds of meeting each guideline increased with each additional year. However, for 3 guidelines there was an initial decline in adherence from 2012 to 2013 before increasing again in 2014—the recommended length, clerkship description, and detailed narrative guidelines. Letters solely written by a chair were less likely to incorporate the guidelines. Insights: Clerkship directors often write the DOM letters and identify with the purpose of the guidelines. As writers, lower ranking academic faculty value the guidelines more than higher ranking academic faculty. As readers of DOM letters, higher academic ranking faculty value letters that incorporate the guidelines more than lower academic ranking faculty. DOM letters implemented more guideline criteria since the guidelines were released. If implementing the guidelines, chairs should solicit the help of their clerkship director or educational representative when writing DOM letters. Although many clerkship directors read letters for their residency programs, additional program directors' opinions are needed.