Miracle-dz/UniFAR-FTUs huggingface dataset:
Therapeutic Intervention in a Case of Ataxic Dysarthria Associated With a History of Amateur Boxing

The goals of this study were to (a) describe the presenting features of ataxic dysarthria present in a participant with a long history of amateur boxing, (b) describe a novel application of behavioral principles in the treatment of this participant, and (c) discuss implications in the treatment of ataxic dysarthria secondary to boxing. The participant was a 36-year-old male with ataxic dysarthria associated with a 15-year history of amateur boxing. Perceptual intelligibility, perceptual severity, communication attitudes, and communication effectiveness were evaluated. As a result of treatment, the participant eliminated the ataxic characteristics of his speech within structured tasks. Speech patterns were controlled through loudness practice and a gradual increase in utterance length and complexity. This study offers speech-language pathologists an introduction to the topic of amateur boxing and associated neurologic consequences as well as a description of the use of behavioral principles in the treatment of ataxic dysarthria.
Strategies to alleviate the incidence of ascites in broilers: a review

Ascites is a complex problem caused by many interacting factors such as genetics, environment and management. Many nutritional, medicinal and management strategies have been proposed to alleviate the problem. Higher levels of dietary vitamin C and E along with selenium yeast might be beneficial, presumably because of their role in improving cellular integrity. Oils rich in n-3 fatty acids have been shown to reduce pulmonary hypertension and, consequently, ascites incidence. The potential use of flax oil has already been demonstrated, whereas the effects of other oils rich in n-3 fatty acids (fish, linseed and canola oils) remain to be investigated. The assessment of the effects of dietary electrolyte balance on ascites incidence seems to be a promising field of research in broiler nutrition. In general, reducing the dietary level of salt (NaCl) and adding bicarbonates to the diet and drinking water have been proposed as potential icost-effectivei methods to reduce ascites incidence. The use of nutrients/drug agents that increase the vascular capacity of the lungs or decrease the pulmonary vascular resistance may help to alleviate the problem, but economic and local feed regulations might restrict such use. Diuretics have also shown positive effects, presumably because there is a reduction of sodium and fluid retention in the body; litter humidity however must be closely monitored if diuretics are continuously administered. As the high metabolic rate (fast growth) is a major factor contributing to the susceptibility of broilers to ascites, early-age feed or nutrient restriction (qualitative or quantitative) or light restriction in order to slow down the growth rate seem practically viable methods, since final body weight is not compromised. Optimization of the house temperature and ventilation in cold weather seem helpful practices to decrease ascites incidence. Under practical conditions, it might be interesting to test the additive effects of different approaches when used in combination.
Radar Imaging of Binary Near-Earth Asteroid (66391) 1999 KW4

High-resolution radar images reveal near-Earth asteroid (66391) 1999 KW4 to be a binary system. The ∼1.5-kilometer-diameter primary (Alpha) is an unconsolidated gravitational aggregate with a spin period ∼2.8 hours, bulk density ∼2 grams per cubic centimeter, porosity ∼50%, and an oblate shape dominated by an equatorial ridge at the object's potential-energy minimum. The ∼0.5-kilometer secondary (Beta) is elongated and probably is denser than Alpha. Its average orbit about Alpha is circular with a radius ∼2.5 kilometers and period ∼17.4 hours, and its average rotation is synchronous with the long axis pointed toward Alpha, but librational departures from that orientation are evident. Exotic physical and dynamical properties may be common among near-Earth binaries.
Integrating e-commerce and data mining: architecture and challenges

We show that the e-commerce domain can provide all the right ingredients for successful data mining. We describe an integrated architecture for supporting this integration. The architecture can dramatically reduce the pre-processing, cleaning, and data understanding effort often documented to take 80% of the time in knowledge discovery projects. We emphasize the need for data collection at the application server layer (not the Web server) in order to support logging of data and metadata that is essential to the discovery process. We describe the data transformation bridges required from the transaction processing systems and customer event streams (e.g., clickstreams) to the data warehouse. We detail the mining workbench, which needs to provide multiple views of the data through reporting, data mining algorithms, visualization, and OLAP. We conclude with a set of challenges.
Pituitary Tumor Transforming Gene Causes Aneuploidy and p53-dependent and p53-independent Apoptosis*

The pituitary tumor transforming gene, PTTG, is abundantly expressed in several neoplasms. We recently showed that PTTG overexpression is associated with apoptosis and therefore have now studied the role of p53 in this process. In MCF-7 breast cancer cells that express wild type p53, PTTG overexpression caused apoptosis. p53 was translocated to the nuclei in cells expressing PTTG. Overexpression of p53, along with PTTG, augmented apoptosis, whereas expression of the human papillomavirus E6 protein inhibited PTTG-induced apoptosis. In MG-63 osteosarcoma cells that are deficient in p53, PTTG caused cell cycle arrest and subsequent apoptosis that was inhibited by caspase inhibitors. A proteasome inhibitor augmented PTTG expression in stable PTTG transfectants, suggesting that down-regulated PTTG expression is required for cell survival. Finally, MG-63 cells expressing PTTG showed signs of aneuploidy including the presence of micronuclei and multiple nuclei. These results indicate that PTTG overexpression causes p53-dependent and p53-independent apoptosis. In the absence of p53, PTTG causes aneuploidy. These results may provide a mechanism for PTTG-induced tumorigenesis whereby PTTG mediates aneuploidy and subsequent cell transformation.
A case study in top-down performance estimation for a large-scale parallel application

This work presents a general methodology for estimating the performance of an HPC workload when running on a future hardware architecture. Further, it demonstrates the methodology by estimating the performance of a significant scientific application -- the Gyrokinetic Toroidal Code (GTC) -- when executing on Sun's proposed next-generation petascale computer architecture.For GTC, we identify the important phases of the iteration and perform low-level analysis that includes instruction tracing and component simulations of processor and memory systems. Low-level analysis is complemented with scalability estimates based on modeling MPI, OpenMP and I/O activity in the code. The work's approach permits accurate end-to-end performance projections from the microarchitecture level to the petascale.
Attachment as an Organizational Framework for Research on Close Relationships

Recent years have witnessed a proliferation of research on close relationships and the emergence of a new relationship subdiscipline within the social sciences. To date, the new science of relationships has been dominated by data. This article is based on the conviction that progress now hinges on the development of theory to organize and interpret extant findings and to guide future investigations. Through a selective but extensive review of the major bodies of empirical literature, we attempt to show that attachment theory can incorporate a broad range of findings on adult relationships. In addition, attachment theory addresses an impressive array of research questions concerning the functions, emotional dynamics, evolutionary origins, and developmental pathways of human affectional bonds. We conclude that a comprehensive theory of close relationships is both desirable and, with the integration of existing theories and concepts, currently achievable.
Coordinated optimal placement of distributed generation and voltage regulator by multi-objective efficient PSO algorithm

The ever rising demand of electrical energy consumption has led to increased use of distributed generation (DG) sources. Nowadays integration of distributed generation units in electrical distribution networks is an important aspect. This paper proposes a new approach for optimally determining the size and location of DG in coordination with location and tap setting of voltage regulator (VR). A multi-objective optimization problem aims at voltage profile improvement, minimization of power loss, voltage stability enhancement and minimum number of tap operations of voltage regulator. An efficient and novel particle swarm optimization (PSO) algorithm is developed to solve this optimization problem which uses ranked initial particle population instead of randomly generated one. The objective function is evaluated using Jacobian based power flow method. Results obtained on a standard 33 bus Radial Distribution System (RDS) demonstrate the effectiveness of the proposed methodology.
A nascent membrane protein is located adjacent to ER membrane proteins throughout its integration and translation

The immediate environment of nascent membrane proteins undergoing integration into the ER membrane was investigated by photocrosslinking. Nascent polypeptides of different lengths, each containing a single IgM transmembrane sequence that functions either as a stop-transfer or a signal-anchor sequence, were synthesized by in vitro translation of truncated mRNAs in the presence of N epsilon-(5-azido-2-nitrobenzoyl)- Lys-tRNA, signal recognition particle, and microsomal membranes. This yielded nascent chains with photoreactive probes at one end of the transmembrane sequence where two lysine residues are located. When irradiated, these nascent chains reacted covalently with several ER proteins. One prominent crosslinking target was a glycoprotein similar in size to a protein termed mp39, shown previously to be situated adjacent to a secretory protein during its translocation across the ER membrane (Krieg, U. C., A. E. Johnson, and P. Walter. 1989. J. Cell Biol. 109:2033-2043; Wiedmann, M., D. Goerlich, E. Hartmann, T. V. Kurzchalia, and T. A. Rapoport. 1989. FEBS (Fed. Eur. Biochem. Soc.) Lett. 257:263-268) and likely to be identical to a protein previously designated the signal sequence receptor (Wiedmann, M., T. V. Kurzchalia, E. Hartmann, and T. A. Rapoport. 1987. Nature (Lond.). 328:830-833). Changing the orientation of the transmembrane domain in the bilayer, or making the transmembrane domain the first topogenic sequence in the nascent chain instead of the second, did not significantly alter the identities of the ER proteins that were the primary crosslinking targets. Furthermore, the nascent chains crosslinked to the mp39-like glycoprotein and other microsomal proteins even after the cytoplasmic tail of the nascent chain had been lengthened by nearly 100 amino acids beyond the stop-transfer sequence. Yet when the nascent chain was allowed to terminate normally, the major photocrosslinks were no longer observed, including in particular that to the mp39-like glycoprotein. These results show that the transmembrane segment of a nascent membrane protein is located adjacent to the mp39-like glycoprotein and other ER proteins during the integration process, and that at least a portion of the nascent chain remains in close proximity to these ER proteins until translation has been completed.
Seasonal Variation of Myostatin Gene Expression in Pectoralis Muscle of House Sparrows (Passer domesticus) Is Consistent with a Role in Regulating Thermogenic Capacity and Cold Tolerance

Winter acclimatization in small birds overwintering in cold climates, including house sparrows (Passer domesticus), is associated with improved cold tolerance, elevated summit metabolic rates (Msum = maximum cold‐induced metabolic rate), and increased pectoralis muscle mass compared to summer birds. Myostatin is a potent autocrine/paracrine inhibitor of skeletal muscle growth in mammals and birds and is a potential candidate for regulation of seasonal phenotypic flexibility in birds. As a first step toward examining such a role for myostatin in small birds, we measured summer and winter gene expression of myostatin and its potential metalloproteinase activators TLL‐1 and TLL‐2 in house sparrows from southeastern South Dakota. Gene expression of myostatin decreased significantly in winter, with summer values exceeding winter values by 1.52‐fold. Moreover, gene expression of TLL‐1 was also significantly reduced in winter, with summer values exceeding winter values by 1.55‐fold. These data are consistent with the hypothesis that the winter increases in pectoralis muscle mass, Msum, and cold tolerance in house sparrows are mediated by reduced levels of myostatin and its activator TLL‐1, and they suggest the possibility that myostatin may be a common mediator of phenotypic flexibility of muscle mass in birds.
Application of Landsat 8 for Monitoring Impacts of Wastewater Discharge on Coastal Water Quality

In this study, we examine the capabilities of the Landsat 8 Operational Land Imager (OLI), Thermal Infrared Sensor (TIRS), and Aqua Moderate resolution Imaging Spectroradiometer (MODIS) for monitoring the environmental impact of the 2015 Hyperion Treatment Plant (HTP) wastewater diversion in Santa Monica Bay, California. From 21 September – 2 November 2015, the HTP discharged approximately 39×103 m3 h-1 of treated wastewater into Santa Monica Bay through their emergency 1-mile outfall pipe. Multi-sensor satellite remote sensing was employed to determine the biophysical impact of discharged wastewater in the shallow nearshore environment. Landsat 8 TIRS observed decreased sea surface temperatures (SST) associated with the surfacing wastewater plume. Chlorophyll-a (chl-a) concentrations derived from Landsat 8 OLI and Aqua MODIS satellite sensors were used to monitor the biological response to the addition of nutrient-rich wastewater. In situ chl-a and in situ remote sensing reflectance (Rrs) were measured before, during, and after the diversion event. These in situ data were paired with coincident OLI and MODIS satellite data to yield a more comprehensive view of the changing conditions in Santa Monica Bay due to the wastewater diversion. Two new local chl-a algorithms were empirically derived using in situ data for the OLI and MODIS sensors. These new local chl-a algorithms proved more accurate at measuring chl-a changes in Santa Monica Bay compared to the standard open ocean OC2 and OC3M algorithms, and the regional southern California CALFIT algorithm, as validated by in situ chl-a measurements. Additionally, the local OLI algorithm outperformed the local MODIS algorithm, especially in the nearshore region. A time series of chl-a, as detected by the local OLI chl-a algorithm, illustrated a very large increase in chl-a concentrations during the wastewater diversion, and a subsequent decrease in chl-a after the diversion. Our study demonstrates the capability of using Landsat 8 TIRS and OLI sensors for the monitoring of SST and surface chl-a concentrations at high spatial resolution in nearshore waters and highlights the value of these sensors for assessing the environmental effects of wastewater discharge in a coastal environment.
Programmable residues defined networks for edge data centres

Edge Data Centres (EDC) are often managed by a single administrative entity with logically centralized control. The architectural split of control and data planes and the new control plane abstractions have been touted as Software-Defined Networking (SDN), where the OpenFlow protocol is one common choice for the standardized programmatic interface to data plane devices. However, in the design of an SDN architecture, there is no clear distinction between functional network parts such as core and edge elements. It means that all switches require to support lookups over hundreds of bits with complex actions that have to be specified by multiple tables. In this paper, we propose a new programmable architecture for EDC networks, named Residues Defined Networks (RDN). In RDN, a controller defines a network policy (e.g. connectivity protection) setting flow entries at the edges. Based on these entries, the edge switches assign routeIDs to flows. A route is defined as the remainder of the division (Residue) between a route-ID and a set of switch-IDs within RDN core. In case of failures, emergency routes are compactly encoded as programmable residues forwarding paths written into the packets. RDN scalability is evaluated considering 2-tier Clos topologies which cover mostly EDC deployments supporting up to 2304 servers. A RDN proof-of-concept prototype is implemented in Mininet for network emulation. Also, to increase the accuracy on latency measures, we implement RDN in NetFPGA that is validated in a testbed with 10Gbps Ethernet boards. RDN offers ultra-fast failure recovery (sub-milliseconds carrier grade), achieves low latency with RDN switching time per hop (« 0.6μs) and no jitter within the RDN core.
Development of Physiologically Based Toxicokinetic Models for Improving the Human Indoor Exposure Assessment to Water Contaminants: Trichloroethylene and Trihalomethanes

Generally, ingestion is the only route of exposure that is considered in the risk assessment of drinking water contaminants. However, it is well known that a number of these contaminants are volatile and lipophilic and therefore highly susceptible to being absorbed through other routes, mainly inhalation and dermal. The objective of this study was to develop physiologically based human toxicokinetic (PBTK) models for trihalomethanes (THM) and trichloroethylene (TCE) that will facilitate (1) the estimation of internal exposure to these chemicals for various multimedia indoor exposure scenarios, and (2) consideration of the impact of biological variability in the estimation of internal doses. Five PBTK models describing absorption through ingestion, inhalation and skin were developed for these contaminants. Their concentrations in ambient air were estimated from their respective tap water concentrations and their physicochemical characteristics. Algebraic descriptions of the physiological parameters, varying as a function of age, gender and diverse anthropometric parameters, allow the prediction of the influence of interindividual variations on absorbed dose and internal dosimetry. Simulations for various scenarios were done for a typical human (i.e., 70 kg, 1.7 m) as well as for humans of both genders varying in age from 1 to 90 years. Simulations show that ingestion contributes to less than 50% of the total absorbed dose or metabolized dose for all chemicals. This contribution to internal dosimetry, such as maximal venous blood concentrations (Cmax) and the area under the venous blood concentration time curve (AUC), decreases markedly (e.g., as low as 0.9% of Cmax for bromodichloromethane). The importance of this contribution varies mainly as a function of shower duration. Moreover, model simulations indicate that multimedia exposure is more elevated in children than adults (i.e., up to 200% of the adult internal dose). The models developed in this study allow characterization of the influence of the different routes of exposure and an improved estimation of the realistic multimedia exposure to volatile organic chemicals present in drinking water. Hence, such models will greatly improve health risk assessment for these chemicals.
The Role of Deception in Complex Social Interaction

Social participation requires certain abilities: communication with other members of society; social understanding which enables planning ahead and dealing with novel circumstances; and a theory of mind which makes it possible to anticipate the mental state of another. In childhood play we learn how to pretend, how to put ourselves in the minds of others, how to imagine what others are thinking and how to attribute false beliefs to them. Without this ability we would be unable to deceive and detect deception in the actions of others, and our ability to interact within our social group would be greatly impaired. In this paper I claim that the capacity for deception is necessary for a theory of mind, and a theory of mind is necessary for complex social interaction.
Persistence of skin-resident memory T cells within an epidermal niche

Significance Tissue-resident memory T cells (TRM) form in the skin where they are retained and can protect against subsequent infection. Using a combination of intravital imaging and mathematical modeling of skin TRM that form after cutaneous herpes simplex virus 1 infection, we reveal that these memory T cells persist at the site of infection for the life of a mouse owing to slow random migration. We also report that TRM compete with dendritic epidermal γδ T cells in skin for local survival signals, suggesting that T cells compete for space within an epidermal niche. Barrier tissues such as the skin contain various populations of immune cells that contribute to protection from infections. These include recently identified tissue-resident memory T cells (TRM). In the skin, these memory CD8+ T cells reside in the epidermis after being recruited to this site by infection or inflammation. In this study, we demonstrate prolonged persistence of epidermal TRM preferentially at the site of prior infection despite sustained migration. Computational simulation of TRM migration within the skin over long periods revealed that the slow rate of random migration effectively constrains these memory cells within the region of skin in which they form. Notably, formation of TRM involved a concomitant local reduction in dendritic epidermal γδ T-cell numbers in the epidermis, indicating that these populations persist in mutual exclusion and may compete for local survival signals. Accordingly, we show that expression of the aryl hydrocarbon receptor, a transcription factor important for dendritic epidermal γδ T-cell maintenance in skin, also contributes to the persistence of skin TRM. Together, these data suggest that skin tissue-resident memory T cells persist within a tightly regulated epidermal T-cell niche.
Permanent magnet flux linkage adaptive observer for permanent magnet synchronous motor

In order to monitor the state of permanent magnet(PM) in PMSM, a design strategy of adaptive observer is proposed. The observer is built bases on the theory of Popov's hyper-stability theory. Then the influences of parameter variations on the PM flux linkage estimation are investigated. It is shown that the q-axis inductance Lq mismatch has the most serious influence on the flux estimation. To reduce the sensitivity of Lq, a flux adaptive observer combined with Lq is proposed in this paper. Experimental results verify the effect of this method.