Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-term outcomes following development of new-onset atrial fibrillation during sepsis.

BACKGROUND New-onset atrial fibrillation (AF) is associated with adverse outcomes during a sepsis hospitalization; however, long-term outcomes following hospitalization with sepsis-associated new-onset AF are unclear. METHODS We used a Medicare 5% sample to identify patients who survived hospitalization with sepsis between 1999 and 2010. AF status was defined as no AF, prior AF, or new-onset AF based on AF claims during and prior to a sepsis hospitalization. We used competing risk models to determine 5-year risks of AF occurrence, heart failure, ischemic stroke, and mortality after the sepsis hospitalization, according to AF status during the sepsis admission. RESULTS We identified 138,722 sepsis survivors, of whom 95,536 (69%) had no AF during sepsis, 33,646 (24%) had prior AF, and 9,540 (7%) had new-onset AF during sepsis. AF occurrence following sepsis hospitalization was more common among patients with new-onset AF during sepsis (54.9%) than in patients with no AF during sepsis (15.5%). Compared with patients with no AF during sepsis, those with new-onset AF during sepsis had greater 5-year risks of hospitalization for heart failure (11.2% vs 8.2%; multivariable-adjusted hazard ratio [HR], 1.25; 95% CI, 1.16-1.34), ischemic stroke (5.3% vs 4.7%; HR, 1.22; 95% CI, 1.10-1.36), and death (74.8% vs 72.1%; HR, 1.04; 95% CI,1.01-1.07). CONCLUSIONS Most sepsis survivors with new-onset AF during sepsis have AF occur after discharge from the sepsis hospitalization and have increased long-term risks of heart failure, ischemic stroke, and death. Our findings may have implications for posthospitalization surveillance of patients with new-onset AF during a sepsis hospitalization.
Keratitis in Dry Eye Disease and Topical Ciclosporin A

ABSTRACT Tear film alterations in dry eye disease (DED) include reduced tear volume and an increase in inflammatory cytokines. Instability and reduced tear production initiate a vicious cycle where hyperosmolarity, ocular inflammation, and apoptosis may induce damage of the ocular surface including keratitis. Topical cyclosporine (CsA) has been used for the treatment of moderate-to-severe DED; however, previous studies failed to demonstrate its benefits by the European Agency standards. A new formulation of CsA 0.1% has been recently approved in the EU to treat severe keratitis in DED patients. Patients with severe keratitis showed a better improvement after 6 months of treatment with CsA compared with vehicle. HLA-DR expression was significantly reduced by CsA treatment. The clinically significant improvement in keratitis associated with the inflammatory biomarker HLA-DR confirms the efficacy of CsA to improve inflammation and its damaging effect on the ocular surface in DED patients.
Achieving secure and flexible M-services through tickets

Web services via wireless technologies, mobile services (M-services), HTTP, and XML have become important for conducting business. W3C XML Protocol Working Group has been developing standard techniques such as Web Services Description Language (WSDL), simple object access protocol (SOAP), universal description discovery and integration (UDDI). However, at this stage, there is no standard technique for access control in M-services. This paper describes a secure and flexible access control scheme and protocol for M-services based on role based access control (RBAC). The access control architecture involves a Trusted Credential Center (TCC), a Trusted Authentication and Registration Center (TARC) and a secure ticket based mechanism for service access. Users and service providers register with the TARC and are authenticated. Based on this, tickets are issued by the TCC to users. Tickets carry authorization information needed for the requested services. In particular, we are able to specify access control polices based on roles. The protocols between the various entities in the model are protected using appropriate security mechanisms such as signatures which are used to verify correctness of the requested service, as well as to direct billing information to the appropriate user. Our architecture supports efficient authentication of users and service providers over different domains and provides a secure access model for services to users. Our model is also able to support anonymity of users. Only the TARC is able to identify misbehaving users. We believe that the proposed architecture forms a good basis for achieving a secure and flexible M-service system.
The meaning of illness to a long-term survivor.

OBJECTIVES To review the ways in which cancer survivors find meaning in their illness experiences. DATA SOURCES Research literature and professional and personal experiences. CONCLUSIONS Survivors confront a number of issues as they try to find a place for their cancer experience in their lives and adopt different approaches to cope with their survivorship. IMPLICATIONS FOR NURSING PRACTICE Nurses can assist cancer survivors to find meaning in their illness experience by understanding the symptoms and issues associated with survival.
Recovery from "hepatorenal syndrome" after orthotopic liver transplantation.

Abstract Three patients with progressive renal failure and advanced hepatic insufficiency due to cirrhosis of the liver underwent orthotopic liver transplantation. All three patients had immediate improvement in hepatic function and within two weeks after liver replacement regained nearly normal kidney function. However, the renal recovery was delayed in each case, and its course was not uniform. Plasma renin activity was high, and renin substrate was low before transplantation in one case in which these measurements were obtained; both returned to normal soon after liver replacement. (N Engl J Med 289:1155–1159, 1973)
AKAP9 Is Essential for Spermatogenesis and Sertoli Cell Maturation in Mice

Mammalian male fertility relies on complex inter- and intracellular signaling during spermatogenesis. Here we describe three alleles of the widely expressed A-kinase anchoring protein 9 (Akap9) gene, all of which cause gametogenic failure and infertility in the absence of marked somatic phenotypes. Akap9 disruption does not affect spindle nucleation or progression of prophase I of meiosis but does inhibit maturation of Sertoli cells, which continue to express the immaturity markers anti-Mullerian hormone and thyroid hormone receptor alpha in adults and fail to express the maturation marker p27Kip1. Furthermore, gap and tight junctions essential for blood–testis barrier (BTB) organization are disrupted. Connexin43 (Cx43) and zona occludens-1 are improperly localized in Akap9 mutant testes, and Cx43 fails to compartmentalize germ cells near the BTB. These results identify and support a novel reproductive tissue-specific role for Akap9 in the coordinated regulation of Sertoli cells in the testis.
A role for CRH and HPA Activation in the Regulation of Plasticity Signaling, Neuroinflammation and Emotional/Mnesic Behavior Following Global Cerebral Ischemia in Rats

Depression occurs in about one third of patients with stroke and cardiac arrest. Hyperactivity of the stress system is the most commonly observed neuroendocrine change in major depressive disorder (MDD), which involves elevated levels in the cerebrospinal fluid of corticotropinreleasing hormone (CRH), a key stress neurohormone. Substantial evidence suggests that normalization of the stress system may be a requirement for successful treatment of MDD through region-specific changes in the mesocorticolimbic circuitry. Thus, alteration in the stress system may underlie the emotional and functional impairments observed following brain ischemic events. In addition, recent findings suggest that ischemic brain injury triggers a restorative process, creating a cerebral environment similar to that of early brain development, a period characterized by rapid neuronal growth and neuroplasticity, critical to optimize functional recovery of individuals post stroke. In particular brain-derived neurotrophic factor (BDNF), has been shown to play an important role in the pathophysiology of major depression and cerebral ischemia. However, whether CRH can mediate the expression of BDNF in the reparative process triggered by ischemic injury remains to be characterized. Therefore, the purpose of the current thesis is to characterize the effect of pharmacological blockade of CRH signaling at the onset of a global ischemic stroke, on emotional and cognitive behaviors, alteration in the neuroendocrine stress system, and markers of neuroplasticity including BDNF. To do this, an animal model of global cerebral ischemia with subsequent behavioral testing and postmortem brain analysis was used to determine underlying biochemical and behavioral changes modulated by CRH signaling following brain ischemia. This doctoral work will help elucidate the relationship between CRH and BDNF in the context of cerebral ischemia, and may provide insights for therapies targeting the stress system. These studies address considerations such as: the interplay
Family Violence: A Review of the Dysfunctional Behavior Patterns

This Study examines family violence and the commonality of mental illness and other psychological problems experienced by the victims. A contrast of historically accepted violent behavior and gender role indifference is reviewed. The importance of external causalities within the victim's environment is discussed from an ecological point of view. Family violence is one of the main causes of serious health and psychological problems for all individuals involved in such an environment. Violence is an ongoing dysfunctional pattern of physical, emotional, and psychological abuse inflicted by the perpetrator. It is demonstrated that violent acts have livelong damaging effects on the victim's mind, body and soul. From an ecological point of view, family violence is a byproduct of today's social, economic and political structure. Social Services across the United States 2 Family Violence: A Review of the Dysfunctional Behavior Patterns
Lifetime and 12 Months Prevalence of Alcohol Use and Alcohol Use Disorders Among Soldiers Residing in a Military Community in Ibadan

ABSTRACT Objective: Aims of the study were to determine lifetime and 12 months prevalence of alcohol use and alcohol use disorders and the profile of problems associated with the diagnoses of alcohol use disorders among a military population in Nigeria. Method: In this descriptive cross-sectional study, 223 military officers were interviewed by multistage stratified systematic sampling method. The Composite International Diagnostic Interview (CIDI) version 7.0 was used to generate data on prevalence of lifetime and current alcohol use, alcohol use disorders, and associated profile of problems. Chi square statistics, Wilcoxon-signed rank test, and binary regression analysis were used to explore the correlates of alcohol use and alcohol use disorder. All analyses were carried using SPSS Version 17.0. Results: Prevalence of lifetime alcohol use was 76.0%, 12 months prevalence was 53.9%, and frequent binge drinking was reported in 6.7% of respondents. Predictors of lifetime alcohol use were: Hausa/Fulani ethnicity OR = 1.51, 95% CI (1.11–8.71), Igbo ethnicity OR = 1.46, 95% CI (1.09–7.01), involvement in combat OR = 1.41, 95% CI (1.01–6.16). Predictors of 12 months alcohol use were: Hausa/Fulani ethnicity OR = 1.98, 95% CI (1.25–8.71), involvement in combat OR = 1.39 95% CI (1.01–5.28) and junior rank soldier OR = 2.08, 95% CI (1.47–8.99) while predictors of lifetime alcohol use disorders were: Hausa/Fulani ethnicity OR = 2.22, 95% CI (1.03–6.99) and involvement in combat OR = 2.04 95% CI (1.12–6.81). Conclusion: Alcohol misuse is highly prevalent in the Nigerian military and its associated factors exemplify the common “military drinking culture. ”
Validation d'une épreuve de planification de l'activité avec des sujets atteints de lésions du cortex préfrontal

Dans cette etude, des sujets normaux, des patients atteints de lesion focale du cortex prefrontal et des patients atteints de lesions non frontales (retrorolandiques) ont passe une epreuve de planification de l'activite concue sous la forme d'un jeu informatise, le « jeu du livreur ». La tâche necessite de preparer un itineraire afin de livrer des colis a des clients. Les patients avec lesion prefrontale presentent des temps de latences initiaux plus courts ainsi que d'importantes difficultes dans le trace de l'itineraire, notamment dans la capacite a tenir compte simultanement des contraintes spatiales et temporelles. Ces resultats confirment que les aires prefrontales jouent un role important dans la gestion des activites complexes et contribuent a la validation du «jeu du livreur » comme moyen d'evaluation de la capacite de planification.
Bipolar-Valued Rough Fuzzy Set and Its Applications to the Decision Information System

In this paper, first, relationship between bipolar-valued fuzzy set and fuzzy set with its extensions is discussed. Second, a new order relation about bipolar-valued fuzzy sets is introduced. Contrary to the existing YinYang order relation about bipolar-valued fuzzy sets, which focuses on the “equilibrium” monotonicity, the new proposed order relation is concerned with “preference” monotonicity. And then, some new operations and related properties about the new defined order relation are presented. Third, by combining bipolar-valued fuzzy set with the rough set theory, the concept of the bipolar-valued rough fuzzy set is developed, which is the first attempt to consider inconsistent bipolarity into rough set theory. Particularly, by introducing two new operations to the rough set theory, the widely existing information losing problem in the computation process is solved. Furthermore, parameter-related and parameter-free rough degrees about the bipolar-valued fuzzy sets in a crisp approximation space are introduced. Finally, the bipolar-valued fuzzy decision information system is given; then, both the attribute reduction method and the knowledge discovery method based on the proposed roughness degree are presented. An example is included to show the feasibility and potential of the obtained theoretical results.
Adenoma detection rate and risk of colorectal cancer and death.

n engl j med 370;26 nejm.org june 26, 2014 2539 tyrosine kinase related to ALK. In fact, previous work established that ceritinib targets both ALK and ROS1 at clinically relevant concentrations, although ceritinib has more potency against ALK.1,2 In ROS1-rearranged NSCLC, resistance to crizotinib may develop owing to the acquisition of a secondary mutation, such as ROS1 G2032R.3 On the basis of the crystal structure of the nonmutant ROS1 kinase domain bound to crizotinib, the substitution of glycine with the bulkier arginine at position 2032 is predicted to cause steric interference with crizotinib binding.3 We speculate that this arginine would also clash sterically with ceritinib, preventing effective binding and inhibition of the kinase. Consistent with this notion, the analogous mutation in ALK (G1202R) causes resistance to ceritinib,4 and in cell-based assays performed in our laboratory, ceritinib is 5 to 10 times less active against ROS1 G2032R than against nonmutant ROS1. Thus, although ceritinib could have activity in ROS1-rearranged NSCLC, we believe that its efficacy would be impaired by the ROS1 G2032R mutation.
Template based protein structure modeling by global optimization in CASP11

For the template‐based modeling (TBM) of CASP11 targets, we have developed three new protein modeling protocols (nns for server prediction and LEE and LEER for human prediction) by improving upon our previous CASP protocols (CASP7 through CASP10). We applied the powerful global optimization method of conformational space annealing to three stages of optimization, including multiple sequence‐structure alignment, three‐dimensional (3D) chain building, and side‐chain remodeling. For more successful fold recognition, a new alignment method called CRFalign was developed. It can incorporate sensitive positional and environmental dependence in alignment scores as well as strong nonlinear correlations among various features. Modifications and adjustments were made to the form of the energy function and weight parameters pertaining to the chain building procedure. For the side‐chain remodeling step, residue‐type dependence was introduced to the cutoff value that determines the entry of a rotamer to the side‐chain modeling library. The improved performance of the nns server method is attributed to successful fold recognition achieved by combining several methods including CRFalign and to the current modeling formulation that can incorporate native‐like structural aspects present in multiple templates. The LEE protocol is identical to the nns one except that CASP11‐released server models are used as templates. The success of LEE in utilizing CASP11 server models indicates that proper template screening and template clustering assisted by appropriate cluster ranking promises a new direction to enhance protein 3D modeling. Proteins 2016; 84(Suppl 1):221–232. © 2015 Wiley Periodicals, Inc.
Multiuser MIMO downlink transmission using spatial modulation

This paper presents a novel scheme to transmit signals in a downlink Multiuser Multiple-Input Multiple-Output (MU-MIMO) scenario. The proposed scheme uses the recently introduced Spatial Modulation (SM) technique to transmit a broadcast signal for multiple users. It has the advantage of not requiring Channel State Information (CSI) at the transmitter side, while simultaneously it offers flexibility for transmitting different quantity of bits per user. Analytical and Monte Carlo Simulations results are reported. For the analyzed cases, the proposed scheme has performance gain of 10 dB for an Average Bit Error Probability (ABEP) of approximately 10-3, when compared to the conventional channel inversion scheme based on precoding with knowledge of the CSI.
Development of 2-Methoxyhuprine as Novel Lead for Alzheimer’s Disease Therapy

Tacrine (THA), the first clinically effective acetylcholinesterase (AChE) inhibitor and the first approved drug for the treatment of Alzheimer’s disease (AD), was withdrawn from the market due to its side effects, particularly its hepatotoxicity. Nowadays, THA serves as a valuable scaffold for the design of novel agents potentially applicable for AD treatment. One such compound, namely 7-methoxytacrine (7-MEOTA), exhibits an intriguing profile, having suppressed hepatotoxicity and concomitantly retaining AChE inhibition properties. Another interesting class of AChE inhibitors represents Huprines, designed by merging two fragments of the known AChE inhibitors—THA and (−)-huperzine A. Several members of this compound family are more potent human AChE inhibitors than the parent compounds. The most promising are so-called huprines X and Y. Here, we report the design, synthesis, biological evaluation, and in silico studies of 2-methoxyhuprine that amalgamates structural features of 7-MEOTA and huprine Y in one molecule.
Environmental Health Research Involving Human Subjects: Ethical Issues

This article reviews some of the ethical issues that arise in environmental health research with human subjects, such as minimizing risks to subjects, balancing benefits and risks in research, intentional exposure studies with human subjects, protecting third parties in research, informing subjects about environmental hazards, communicating health information to subjects, and protecting privacy and confidentiality.
Gene Regulation by CcpA and Catabolite Repression Explored by RNA-Seq in Streptococcus mutans

A bacterial transcriptome of the primary etiological agent of human dental caries, Streptococcus mutans, is described here using deep RNA sequencing. Differential expression profiles of the transcriptome in the context of carbohydrate source, and of the presence or absence of the catabolite control protein CcpA, revealed good agreement with previously-published DNA microarrays. In addition, RNA-seq considerably expanded the repertoire of DNA sequences that showed statistically-significant changes in expression as a function of the presence of CcpA and growth carbohydrate. Novel mRNAs and small RNAs were identified, some of which were differentially expressed in conditions tested in this study, suggesting that the function of the S. mutans CcpA protein and the influence of carbohydrate sources has a more substantial impact on gene regulation than previously appreciated. Likewise, the data reveal that the mechanisms underlying prioritization of carbohydrate utilization are more diverse than what is currently understood. Collectively, this study demonstrates the validity of RNA-seq as a potentially more-powerful alternative to DNA microarrays in studying gene regulation in S. mutans because of the capacity of this approach to yield a more precise landscape of transcriptomic changes in response to specific mutations and growth conditions.
Development and validation of the collaborative parent involvement scale for youths with type 1 diabetes.

OBJECTIVE To develop and test a youth-report measure of collaborative parent involvement in type 1 diabetes management. METHODS Initial item development and testing were conducted with 81 youths; scale refinement and validation were conducted with 122 youths from four geographic regions. Descriptive statistics, Cronbach's alpha, and factor analyses were conducted to select items comprising the scale. Correlations with parenting style and parent diabetes responsibility were examined. Multiple regression analyses examining associations with quality of life, adherence, and glycemic control were conducted to assess concurrent validity. RESULTS The measure demonstrated strong internal consistency. It was modestly associated with parenting style, but not with parent responsibility for diabetes management. A consistent pattern of associations with quality of life and adherence provide support for the measure's concurrent validity. CONCLUSIONS This brief youth-report measure of parent collaborative involvement assesses a unique dimension of parent involvement in diabetes management associated with important youth outcomes.
The Influence of Postnatal Psychiatric Disorder on Child Development

There is considerable evidence that maternal postnatal psychiatric disorder has an adverse influence on infant development. In attempting to examine the pathways of intergenerational transmission, most research has concentrated on genetic factors or on maternal behaviours during mother-child interaction and attachment. However, researchers have largely ignored the possible role of maternal cognition underlying behaviour, especially the thought and attentional processes involved in psychiatric disorders. This paper argues that a particular form of maternal cognition, namely ‘preoccupation’, is one key, but under-recognised, mechanism in the transmission of psychiatric disturbance. We propose that preoccupation interferes with specific aspects of mental functioning, especially attention and responsivity to the environment. This impairs the mother’s parenting capacities and adversely affects mother-child interaction and child development.