Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of low-load resistance training on the tendon properties in middle-aged and elderly women.

AIM The purposes of this study were to determine the age-related changes in the tendon-aponeurosis structures and to investigate the effects of low-load resistance training on the tendon-aponeurosis structures in middle-aged and elderly women. METHODS Fifty-one women (55.8 +/- 13.7 years, range: 21-77 years) volunteered to take part in the present study. Furthermore, 11 middle-aged and elderly women (49.7 +/- 9.2 years) performed the low-load resistance training, i.e. squat using body weight, for 6 months. The elongation of the tendon and aponeurosis of the vastus lateralis muscle was directly measured by ultrasonography, while the subjects performed ramp isometric knee extension up to the voluntary maximum, followed by a ramp relaxation. The relationship between the estimated muscle force (Fm) and tendon elongation (L) during the ascending phase was fitted to a linear regression, the slope of which was defined as stiffness. The percentage of the area within the Fm-L loop to the area beneath the curve during the ascending phase was calculated as hysteresis. RESULTS Maximal strain (L/initial tendon length) and stiffness of the tendon-aponeurosis structures decreased significantly with ageing. In contrast, the hysteresis increased significantly with ageing. In addition, low-load resistance training produced no significant change in stiffness and hysteresis, but significantly increased the maximal elongation of tendon-aponeurosis structures from 23.3 +/- 2.1 mm to 24.8 +/- 2.2 mm (P = 0.045). CONCLUSION These results suggest that increasing age results in a decrease in the elasticity of tendon-aponeurosis structures and an increase in their viscosity. Furthermore, the low-load resistance training made the elasticity of tendon-aponeurosis structures increase.
Modulation of Ion Channels in the Axon: Mechanisms and Function

The axon is responsible for integrating synaptic signals, generating action potentials (APs), propagating those APs to downstream synapses and converting them into patterns of neurotransmitter vesicle release. This process is mediated by a rich assortment of voltage-gated ion channels whose function can be affected on short and long time scales by activity. Moreover, neuromodulators control the activity of these proteins through G-protein coupled receptor signaling cascades. Here, we review cellular mechanisms and signaling pathways involved in axonal ion channel modulation and examine how changes to ion channel function affect AP initiation, AP propagation, and the release of neurotransmitter. We then examine how these mechanisms could modulate synaptic function by focusing on three key features of synaptic information transmission: synaptic strength, synaptic variability, and short-term plasticity. Viewing these cellular mechanisms of neuromodulation from a functional perspective may assist in extending these findings to theories of neural circuit function and its neuromodulation.
The research of broadband MIMO millimeter wave transceiver system: Design and test

A design of broadband multiple-input and multiple-output(MIMO) millimeter wave transceiver system is developed in this paper. The millimeter wave(mm-wave) transceiver system includes the ultra-wide bandwidth baseband data processing unit (BAP), intermediate frequency module (IF), mm-wave frontend and the power module. The developed system can support 4×4 MIMO configuration. The mm-wave frequency of the transceiver is 28 GHz and the channel bandwidth is up to 500 MHz. The architecture adopts an intermediate frequency of 2.75 GHz, and the receiving link adopts digital intermediate frequency sampling. Meantime, the launch link uses a secondary frequency conversion structure. Link tests and system tests with the antenna arrays are conducted. The experiment results show that the developed system works well and provides hardware basis for future mm-wave broadband access applications.
Treatment of acute ischemic brain infarction with the assistance of local intraarterial thrombolysis with recombinant tissue-type plasminogen activator

Background: Cerebral infarction is usually due to arterial occlusion. Prompt treatment with thrombolytic drugs can restore blood flow and improve recovery from an infarct. Purpose: To evaluate the clinical efficacy and safety of local intraarterial thrombolysis with recombinant tissue-type plasminogen activator (rtPA) in patients with acute middle cerebral artery (MCA) infarctions within 6 hours of the onset of symptoms. Material and Methods: Sixteen patients (10 females and six males) aged from 42 to 61 years, with acute MCA territory infarcts were selected for treatment with local i.a. rtPA up to 6 hours after the onset of symptoms. Patient selection was based on clinical examination, computed tomography (CT), and digital subtraction angiography (DSA). A clinical evaluation was performed before treatment, at the time of discharge, and 90 days post-procedure on the basis of modified Rankin and NIHSS scores. Controls (n = 16, nine females and seven males) aged from 51 to 70 years were treated only with intravenous anticoagulation using i.v. heparin infusion. The control group was evaluated with multidetector CT (MDCT) angiography performed on entry to the study and at 2–4 hours afterwards. Results: Eight patients (50%) achieved a modified Rankin score of 2 or less as the primary outcome after 90 days follow-up. The secondary clinical outcome at 90-day follow-up was as follows: NIHSS score ⩽1, three (19%) of the patients; NIHSS score ⩾50% decrease, nine (56%) of the patients. A recanalization rate of 75% was achieved in 12 of the 16 treated patients, but only 12.5% in two of the 16 patients in the control group. Intracerebral hemorrhage occurred in two (12.5%) of the patients in the treatment group, but in only one patient (6%) in the control group. There were no deaths in the treated group after thrombolysis up to the time of discharge; however, during the 90-day follow-up, two patients died compared to three patients in the control group (19% vs. 12.5% mortality rate). Conclusion: Patients with cerebral infarction who were treated within 6 hours of onset using intraarterial rtPA thrombolysis had a significantly improved clinical outcome 90 days after the procedure compared to patients treated only with intravenous anticoagulation.
A new approach of FMCW-DBS altimeters for terrain-aided navigation

We are developing a low-cost radar altimeter for terrain-aid navigation application. The position estimator is properly designed understanding the limitation of the altimeter range measurement system. Our initial study reveals that conventional wide-beam altimeters or non-interferometric SAR-based altimeters work well with the non-linear estimator that propagates the probability density functions (PDFs).
Developing a Successful e-Government

PCT No. PCT/GB93/01904 Sec. 371 Date May 3, 1995 Sec. 102(e) Date May 3, 1995 PCT Filed Sep. 9, 1993 PCT Pub. No. WO94/07097 PCT Pub. Date Mar. 31, 1994A temperature-controlled cabinets, particularly, refrigerators, freezers, fridge-freezers and drinks coolers (chillers) which, in order to overcome the problem of inferior insulative properties of alternative polyurethane foams used to reduce the emission of CFC's during injection and setting of foamed polyurethane, provides a cabinet within which a controllable stable temperature may be maintained. This cabinet includes an inner container (25a), an outer shell (10a), and a thermally insulating material (45a) sandwiched therebetween, wherein at least a portion of a front side (50a) of the outer shell (10a) has a panel (85a) which is displaced outwardly from the rest of the front side (50a) of the outer shell (10a). In a preferred embodiment, the cabinet forms a chest freezer (5a).
Spatial Regression Models to Improve P2P Credit Risk Management

Calabrese et al. (2017) have shown how binary spatial regression models can be exploited to measure contagion effects in credit risk arising from bank failures. To illustrate their methodology, the authors have employed the Bank for International Settlements' data on flows between country banking systems. Here we apply a binary spatial regression model to measure contagion effects arising from corporate failures. To derive interconnectedness measures, we use the World Input-Output Trade (WIOT) statistics between economic sectors. Our application is based on a sample of 1,185 Italian companies. We provide evidence of high levels of contagion risk, which increases the individual credit risk of each company.
Efalizumab for patients with moderate to severe plaque psoriasis: a randomized controlled trial.

CONTEXT Because T-cell interactions are involved in the pathophysiology of psoriasis, therapy with a T-cell modulator may have beneficial effects on psoriasis severity and health-related quality of life (HRQL). OBJECTIVE To assess the efficacy and safety of efalizumab, a T-cell modulator, in patients with plaque psoriasis. DESIGN, SETTING, AND PATIENTS Phase 3 randomized, double-blind, parallel-group, placebo-controlled trial involving 556 adult patients with stable, moderate to severe plaque psoriasis and conducted at 30 study centers in the United States and Canada between January and July 2002. INTERVENTIONS Patients were randomly assigned in a 2:1 ratio to receive 12 weekly doses of subcutaneous efalizumab, 1 mg/kg (n = 369), or placebo equivalent (n = 187). MAIN OUTCOME MEASURES At least 75% improvement on the Psoriasis Area and Severity Index (PASI-75); improvement on the overall Dermatology Life Quality Index (DLQI), Itching Visual Analog Scale (VAS), and Psoriasis Symptom Assessment (PSA) at week 12 vs baseline. RESULTS Efalizumab-treated patients experienced significantly greater improvement on all end points than placebo-treated patients. Twenty-seven percent of efalizumab-treated patients achieved PASI-75 vs 4% of the placebo group ( P<.001). Efalizumab-treated patients exhibited significantly greater mean percentage improvement than placebo-treated patients on the overall DLQI (47% vs 14%; P<.001), Itching VAS (38% vs -0.2%; P<.001), and PSA frequency and severity subscales (48% vs 18% and 47% vs 17%, respectively; P<.001 for both) at the first assessment point. Efalizumab was safe and well tolerated, with primarily mild to moderate adverse events. CONCLUSION In this 12-week study, efalizumab resulted in significant improvements in clinical end points, including physician-assessed and dermatology-specific patient-reported HRQL measures, in patients with moderate to severe plaque psoriasis.
Herbaceous Angiosperms Are Not More Vulnerable to Drought-Induced Embolism Than Angiosperm Trees1[OPEN]

Herbs display a wide range of embolism resistance and do not show pronounced embolism formation throughout the growing season. The water transport pipeline in herbs is assumed to be more vulnerable to drought than in trees due to the formation of frequent embolisms (gas bubbles), which could be removed by the occurrence of root pressure, especially in grasses. Here, we studied hydraulic failure in herbaceous angiosperms by measuring the pressure inducing 50% loss of hydraulic conductance (P50) in stems of 26 species, mainly European grasses (Poaceae). Our measurements show a large range in P50 from −0.5 to −7.5 MPa, which overlaps with 94% of the woody angiosperm species in a worldwide, published data set and which strongly correlates with an aridity index. Moreover, the P50 values obtained were substantially more negative than the midday water potentials for five grass species monitored throughout the entire growing season, suggesting that embolism formation and repair are not routine and mainly occur under water deficits. These results show that both herbs and trees share the ability to withstand very negative water potentials without considerable embolism formation in their xylem conduits during drought stress. In addition, structure-function trade-offs in grass stems reveal that more resistant species are more lignified, which was confirmed for herbaceous and closely related woody species of the daisy group (Asteraceae). Our findings could imply that herbs with more lignified stems will become more abundant in future grasslands under more frequent and severe droughts, potentially resulting in lower forage digestibility.
Adult pituitary progenitors/stem cells: from in vitro characterization to in vivo function

Stem cells/progenitors are being discovered in a growing number of adult tissues. They have been hypothesized for a long time to exist in the pituitary, especially because this gland is characterized by its plasticity as it constantly adapts its hormonal response to evolving needs, under the control of the hypothalamus. Recently, five labs have reported the presence of adult progenitors in the gland and shown their endocrine differentiation potential, using different in vitro assays, selection methods and markers to purify and characterize these similar cell populations. These will be discussed here, highlighting common points, and also differences. Thanks to these recent developments it is now possible to integrate progenitors into the physiology of the gland, and uncover their participation in normal but also pathological situations. Moreover, experimental situations inducing generation of new endocrine cells can now be re‐visited in light of the involvement of progenitors, and also used to better understand their role. Some of these aspects will also be developed in this review.
New-Onset Tic Disorder Following Acute Hemorrhage of an Arteriovenous Malformation

The etiology of tic disorder includes idiopathic, postencephalitic, head injury, carbon monoxide poisoning, stroke, and developmental syndromes. We report a case of new-onset complex motor and vocal tics that began after hemorrhage of an arteriovenous malformation located in the left frontal lobe. We have found no reported cases of new-onset tics related to arteriovenous malformations or hemorrhage into the frontal lobes. The patient is a 16-year-old right-hand-dominant boy who presented with generalized tonic-clonic seizures. Evaluation, including magnetic resonance imaging, revealed a left frontal arteriovenous malformation, confirmed by angiogram. Following resection, there was an intraparenchymal hemorrhage of the left frontal lobe with intraventricular hemorrhage, noted most prominently in the left lateral and IIIrd ventricles, and a subdural hematoma caudal to the craniotomy. The postoperative course was complicated by hemiparesis and global aphasia. During recovery, the patient developed what was thought to be a complex partial seizure evidenced by head turning to the right with vocalization and left upper extremity clonic jerks. These were brief and occurred multiple times per day. A trial of carbamazepine was given with no improvement. It was noted that the spells occurred more frequently under stress, as when the patient was frustrated with communication. The diagnosis was changed to complex motor tics and the therapy changed to clonidine. The tics subsequently improved by 80%, although they were still present. We believe the development of complex motor tics due to frontal hemorrhage represents a unique etiology and could complicate postsurgical recovery in similar cases. (J Child Neurol 2000;15:769-771).
Digital Evaluation of Three Splinting Materials Used to Fabricate Verification Jigs for Full‐Arch Implant Prostheses: A Comparative Study

PURPOSE The primary aim of this study was to assess the accuracy of different splinting materials to make implant cast verification jigs. The secondary aim was to assess the effect of 20° implant angulation on the accuracy of casts. MATERIALS AND METHODS An edentulous mandibular arch with five internal connection tissue level implants served as control. The three implants in the anterior region were parallel to each other and the two implants in the posterior region were distally tilted 20° bilaterally. Verification jigs were fabricated with three different materials by splinting prefabricated bars to temporary abutments, resulting in three different groups (n = 15 specimens). Test casts were fabricated with low expansion type IV stone, and subsequently digitized with reference scanner. The STL files from the test casts and the control were superimposed, in order to determine the three-dimensional (3D) deviations. RESULTS Group 1 (GC Pattern Resin) had a mean (SD) value of 36.59 (12.47) μm; Group 2 (Fixpeed Resin) had a mean (SD) value of 35.9 (10.13) μm; and Group 3 (Triad Gel) had a mean (SD) of 34.12 (7.10) μm. One-way ANOVA showed no statistically significant difference between groups (p = 0.790). For the comparative analysis of the effect of implant angulation, data were normally distributed for Groups 1 and 3 (GC Resin and Triad Gel), but not for group 2 (Fixpeed Resin). The difference between parallel and tilted implants was significant for all three groups: GC Resin (p = 0.024; paired t-test), Fixpeed Resin (p = 0.002; Wilcoxon signed-rank test), and Triad Gel (p = 0.002; paired t-test). CONCLUSIONS There were no statistically significant differences between the 3D deviations of the test casts fabricated from verification jigs made by three materials (GC Pattern Resin, Fixpeed Resin, and Triad Gel). Parallel implants had nominally significantly less 3D deviations compared with 20° distally tilted implants, but not clinically significant. CLINICAL SIGNIFICANCE The results of the present study indicate that more than 20° of angulation, has an effect on the 3D accuracy. However, even though the tilted implants had nominally significantly more 3D deviation, it was not clinically significant. The clinical implications of this in vitro study are relevant to the popular full-arch implant rehabilitation concept of tilted and axial implants such as the All-on-four concept. Tilting the posterior implants to increase the antero-posterior spread increases the implant angulation which is then corrected with 30° angulated abutments. This in vitro study shows that even after correction with angulated abutments if the remaining angulation is up to 20°, framework fit may still be achieved. Verification jig is essential tool to achieve the framework fit. (J Esthet Restor Dent 29:102-109, 2017).
A fast convergent and energy efficient offset calibration technique for dynamic comparators

A novel offset calibration technique with fast convergence rate for high-speed dynamic comparators is presented. The circuit utilizes a multi-rate charge pump circuitry to speed up the calibration process while maintaining the precision which leads to better energy efficiency. The circuit is designed in a 0. 13μm CMOS process. Based on Monte-Carlo simulation results the comparator achieves 183. 1μV residual offset within an average convergence time of 82 ns. Based on measurement results the comparator dissipates 5.1 μW from a 1 V power supply at 250 MHz clock frequency, achieving a FOM of 10.2 fJ/conv.
Smoking during pregnancy: how reliable are maternal self reports in New Zealand?

OBJECTIVE: To determine the reliability of self reports of smoking during pregnancy. METHODS: Residual sera from early and late antenatal blood samples were tested for cotinine for all pregnancies over a six month period. Over an overlapping 12 month period, a postal questionnaire on smoking was also sent to all new mothers (n = 4857) when their baby was 4-8 weeks old. Smoking status from obstetric booking notes was also obtained. RESULTS: The cotinine-validated smoking prevalence was 31.3% for the first trimester and 27.7% for the third trimester. Questionnaire self reported prevalences were 19.2% and 15.7% for the first and third trimesters respectively, and 18.9% for obstetric booking. Of cotinine-validated smokers, 22% denied smoking-self deceivers. Of mothers who replied to the questionnaire, a half appeared to systematically under report the amount they smoked. CONCLUSIONS: Nearly a quarter of smoking pregnant women did not report smoking. Moreover, of those who did, the amount smoked was often under reported. This tendency to under report may rise as pressures to stop smoking increase. Accurate measures of smoking prevalence in pregnant women will require objective testing.
Modeling, Fabrication and Investigation of Mixing in Low-Cost Passive PDMS Micromixers

In this work, a lattice Boltzmann method (LBM) modeling and investigation of mixing in a low-cost poydimethylsiloxane (PDMS) micromixer has been discussed. The PDMS micromixers are fabricated using simple printed circuit board (PCB) mold by eliminating the need of UV-lithography and plasma chamber. Thus a low-cost methodology to fabricate a micromixer has been presented. The fabricated device is modeled using mesoscopic LBM and investigation of mixing efficiency is done. Six different passive micromixers with different obstacle pattern are fabricated and characterized using in-house developed characterization system. The result shows that the pattern having more sharp edges along with the roughness provides maximum enhancement of the mixing efficiency. The obtained results can be utilized to design an efficient micromixer for lab-on-a-chip applications.
Bayesian Optimized Importance Sampling for High Sigma Failure Rate Estimation

Due to aggressive technology downscaling, process and runtime variations have a strong impact on the correct functionality in the field as well as manufacturing yield. The assessment of the yield and failure rate is extremely crucial for design optimization. The common practice is to use Monte Carlo simulations in order to account for device variations and estimate failure rate. However, Monte Carlo methods are infeasible for estimating rare events such as high sigma failure rates, and hence, various importance sampling methods have been proposed. In this paper, we present an efficient importance sampling approach based on Bayesian optimization. Its advantages include constant complexity independent of the dimensions of design space, the potential to find the global extrema, and higher trustworthiness of the estimated failure rate. We evaluated the approach on a 6T SRAM cell based on a 28nm FDSOI process. The results show significant speedup and more than two orders of magnitude better accuracy in failure rate estimation, compared to the best state-of-the-art technique.
Roles for Nicotinic Acetylcholine Receptor Subunit Large Cytoplasmic Loop Sequences in Receptor Expression and Function

To evaluate possible physiological roles of the large cytoplasmic loops (C2) and neighboring transmembrane domains of nicotinic acetylcholine receptor (nAChR) subunits, we generated novel fusion constructs in which human nAChR α4, β2, or β4 subunit C2 or C2 and neighboring sequences were replaced by corresponding sequences from the mouse serotonin type 3A (5-HT3A) receptor subunit. Following stable expression in human SH-EP1 cells, we found that extensive sequence substitutions involving third and fourth transmembrane domains and neighboring “proximal” C2 sequences (e.g., β2 H322-V335 and V449-R460) did not allow functional expression of nAChR containing chimeric subunits. However, expression of functional nAChR was achieved containing wild-type α4 subunits and chimeric β2 (β2χ) subunits whose “nested” C2 domain sequences K336-S448 were replaced with the corresponding 5-HT3A subunit sequences. Whereas these findings suggested indispensable roles for M3/M4 transmembrane and/or proximal C2 sequences in α4β2-nAChR function, nested C2 sequences in the β2 subunit are not essential for functional receptor expression. Ligand-binding analyses also revealed only subtle differences in pharmacological profiles of α4β2-nAChR compared with α4β2χ-nAChR. Nevertheless, there was heightened emergence of agonist-mediated self-inhibition of α4β2χ function, greater sensitivity to functional blockade by a number of antagonists, and faster and more complete acute desensitization of α4β2χ-nAChR than for α4β2-nAChR. These studies are consistent with unexpected roles of nested C2 sequences in nAChR function.