Miracle-dz/UniFAR-FTUs huggingface dataset:
Black tea (Camellia sinensis) decoction shows immunomodulatory properties on an experimental animal model and in human peripheral mononuclear cells

Background: Black tea (Camellia sinensis) has been used as a daily beverage for time immemorial. Immunomodulatory effects of tea are recognized as it stimulates the proliferation of cultured human peripheral blood mononuclear cells. Anti-inflammatory effects of tea have also been depicted in the available literature. Therefore, we designed this study to examine the potential immunemodulatory and anti-inflammatory activities of black tea in a rat model and in human peripheral mononuclear cells. Aims: The purpose of the study was to determine (1) evaluation of anti-inflammatory effects of black tea on rats, (2) evaluation of immunemodulator effects of black tea on rats, and (3) evaluation of immunemodulator effects of black tea on human peripheral mononuclear cells. Materials and Methods: Black tea decoction (10% and 20%) was prepared. Acute anti-inflammatory activity of tea decoction was evaluated using carrageenan and dextran whereas chronic anti-inflammatory (Immunomodulatory) effects were evaluated in a complete Freunds’ adjuvant-induced arthritis model. Immunostimulatory role was evaluated in cultured human (in vitro) peripheral mononuclear cells (T-lymphocytes) by using methyl thioazolyl tetrazolium (MTT) and Trypan blue assay. Study Design: An experimental study was designed. Results: Black tea decoction (10% and 20%) strength has shown significant anti-inflammatory effects (64.8% and 77% reduction, respectively), on carrageenan-induced acute inflammatory models (rat paw edema) which can be comparable with the standard drug indomethacin (89.1%). In a chronic anti-inflammatory model, black tea decoction (10% and 20%) has shown significant suppressive effects on rat paw edema (38.56% and 69.53%) observed on 21st day. Lymphoproliferative action of tea was evaluated on human peripheral mononuclear cells using an MTT assay where the number of living cells were expressed in terms of optical density at 570 nm. An experiment has shown that black tea increases the maximum number of T-lymphocytes at 72 h with a maximum strength of 20%. Maximum number of viable cells (T-lymphocytes) was observed with black tea at 20% strength at 72 h. The results were expressed as mean ± SD, and the significance was evaluated by Student's t-test versus control, with P < 0.05 implying significance. Conclusions: Taken together, our data indicate that black tea has potential anti-inflammatory and immunomodulatory action and this corroborates with the current trend of tea being promoted as a ‘health drink’.
Investigating the treatment of chloride-infested archaeological iron objects

Archaeological iron objects become infested with chloride ions during burial. These enhance electrochemical corrosion, acidify the pore solution and form hygroscopic p-FeOOH. Controlling chloride-induced corrosion requires <15% relative humidity (RH) this is difficult to achieve in practice. Iron objects are at significant risk when dry storage is not maintained. Alkaline deoxygenated solutions remove chloride ions from objects. A large quantitative dataset was needed to evaluate the chloride extraction efficiency, the relationship between chloride concentration and corrosion rate and the risks posed by aqueous treatments. Using 120 archaeological iron nails as sample material, and recording chloride extraction behaviour for each individual object, three treatments were tested nitrogen-deoxygenated 0.1M NaOH (20 C) and alkaline sulphite (0.1M NaOH/0.05M Na2S03) at 20 C and 60 C. Objects were subsequently digested to measure residual chloride. Chloride extraction efficiency was 60-99% in most cases 87% of treatments resulted in residual chloride levels <1000 ppm. Accelerated corrosion tests showed that treated objects were more stable than untreated. Post-treatment scanning electron microscopy identified chloride ions in corrosion products or within slag inclusions, but none at the metal/corrosion interface. The transformation of synthetic P-FeOOH showed that 0.5M NaOH or 0.1M NaOH/0.05M Na2S03 (60 C) produced the maximum transformation (c.50%) to a-FeOOH and/or a-Fe203. It could not be confirmed whether this reaction occurs on objects. Risk to objects was evaluated by assessing physical damage during treatment and modelling chemical residues. Less than 2% of objects experienced total fragmentation 69% experienced no change. The most likely chemical residue from alkaline sulphite is Na2S04 this poses no threat to objects at RH <76%. The research reported here is a substantial addition to the body of data about desalination treatment. It improves understanding of the benefits and risks of treatment in relation to developing improved conservation strategies for highly chloride-contaminated objects.
Cell proliferation and protein synthesis as initial factors in determination of axial polarity

The rate of cell proliferation relative to that of protein synthesis appears to have an initial role in establishment of axial polarities in developing animal embryos. An increase in this ratio leads to anterior or dorsal differentiation, while reduction allows posterior or ventral differentiation in a number of organisms. The role that various growth factors play in the regulation of proliferation and protein synthesis is examined.
Control of nucleate boiling with micro-machined surface features

This thesis discusses the production and use of laser-machined boiling grids that provide controlled nucleate boiling and enhanced heat transfer characteristics for application primarily to IC engine cooling systems. The surface features of heated plates are known to have a significant effect on nucleate boiling heat transfer and bubble growth dynamics. Nucleate boiling starts from discrete bubbles that form on surface imperfections, such as cavities or scratches. The gas or vapours trapped in these imperfections serve as nuclei for the bubbles. After inception, the bubbles grow to a certain size and depart from the surface. The bubble departure process significantly increases heat transfer rates compared to pure convection. In this work, special heated surfaces were manufactured by laser machining cavities into polished aluminium plates. This was accomplished with an Nd:YAG laser system, which allowed drilling of cavities of a known diameter. The size range of cavities was 25 to 300 micrometers. The resulting nucleate pool boiling was analysed using a high-speed imaging system comprising an infrared laser and high resolution CCD camera. This system was operated up to a 2 kHz frame rate and digital image processing allowed bubbles to be analysed statistically in terms of departure diameter, departure frequency, growth rate, shape and velocity. Data were obtained for heat fluxes up to 150 kW.m'2. Bubble measurements were obtained working with water at atmospheric pressure. The surface cavity diameters were selected to control the temperature at which vapour bubbles started to grow on the surface. The selected size and spacing of the cavities was also explored to provide optimal heat transfer. Insights into the interaction and interseeding mechanism were obtained. The research has demonstrated that nucleate boiling can be controlled by optimally sized and spaced laser-machined cavities in heated metal surfaces.
A Model-Based Approach for Developing Data Cleansing Solutions

The data extracted from electronic archives is a valuable asset; however, the issue of the (poor) data quality should be addressed before performing data analysis and decision-making activities. Poor data quality is frequently cleansed using business rules derived from domain knowledge. Unfortunately, the process of designing and implementing cleansing activities based on business rules requires a relevant effort. In this article, we illustrate a model-based approach useful to perform inconsistency identification and corrective interventions, thus simplifying the process of developing cleansing activities. The article shows how the cleansing activities required to perform a sensitivity analysis can be easily developed using the proposed model-based approach. The sensitivity analysis provides insights on how the cleansing activities can affect the results of indicators computation. The approach has been successfully used on a database describing the working histories of an Italian area population. A model formalizing how data should evolve over time (i.e., a data consistency model) in such domain was created (by means of formal methods) and used to perform the cleansing and sensitivity analysis activities.
Fractal image compression using genetic algorithm with ranking select mechanism

The demand for images in video sequences and computer animation has increased drastically over the years. This gives attention on an important issue of compression, resulting into reduction in cost of data storage and transmission. For still image compression JPEG is used world -wide. But alternative methods are also being explored; Fractal image compression is one of them. It is based on the self-similarity property to find out the best match within the image itself. This property is used to generate a fractal code. In this paper, the new approach for fractal image compression using genetic algorithm with ranking select mechanism is proposed. This proposed algorithm is applied on fractal as well as non-fractal images and the experimental result shows that the encoding time for both types of images is greatly reduced while maintaining their quality intact.
Intestinal Bacterial Communities of Trypanosome-Infected and Uninfected Glossina palpalis palpalis from Three Human African Trypanomiasis Foci in Cameroon

Glossina sp. the tsetse fly that transmits trypanosomes causing the Human or the Animal African Trypanosomiasis (HAT or AAT) can harbor symbiotic bacteria that are known to play a crucial role in the fly's vector competence. We hypothesized that other bacteria could be present, and that some of them could also influence the fly's vector competence. In this context the objectives of our work were: (a) to characterize the bacteria that compose the G. palpalis palpalis midgut bacteriome, (b) to evidence possible bacterial community differences between trypanosome-infected and non-infected fly individuals from a given AAT and HAT focus or from different foci using barcoded Illumina sequencing of the hypervariable V3-V4 region of the 16S rRNA gene. Forty G. p. palpalis flies, either infected by Trypanosoma congolense or uninfected were sampled from three trypanosomiasis foci in Cameroon. A total of 143 OTUs were detected in the midgut samples. Most taxa were identified at the genus level, nearly 50% at the species level; they belonged to 83 genera principally within the phyla Actinobacteria, Bacteroidetes, Firmicutes, and Proteobacteria. Prominent representatives included Wigglesworthia (the fly's obligate symbiont), Serratia, and Enterobacter hormaechei. Wolbachia was identified for the first time in G. p. palpalis. The average number of bacterial species per tsetse sample was not significantly different regarding the fly infection status, and the hierarchical analysis based on the differences in bacterial community structure did not provide a clear clustering between infected and non-infected flies. Finally, the most important result was the evidence of the overall very large diversity of intestinal bacteria which, except for Wigglesworthia, were unevenly distributed over the sampled flies regardless of their geographic origin and their trypanosome infection status.
Chemokine regulation of atherosclerosis

Oxidative stress and inflammation are accepted as major factors in the pathogenesis of atherosclerosis, but how they interact to produce a plaque has not been delineated clearly. Recent data suggest that oxidized lipids may act in part by regulating production of chemokines and chemokine receptors, which in turn, may direct monocytes and other blood leukocytes to the vessel wall, where they may interact with endothelial cells and smooth muscle cells. The receptors may act at the level of recruitment, retention, and egress, not only through classic, chemotactic mechanisms but also through direct, intercellular adhesion. The results suggest a coordinated mechanism for inflammatory cell accumulation in plaque and identify novel targets, such as CCR2 and CX3CR1, for potential drug development in coronary artery disease.
OFDM With Adaptive Frequency Diversity

Code-division multiplex orthogonal frequency-division multiplex (CDM-OFDM) has received considerable attention due to its superior resilience against subcarrier fading in comparison with conventional OFDM. More recently, group-orthogonal CDM-OFDM (GO-CDM-OFDM) has been considered as a suitable method to extract additional frequency diversity of the wireless channel by splitting the available subcarriers into (orthogonal) groups and applying optimum detection at the receiver on a per-group basis. One critical parameter of this scheme is the group size as it can effectively act like a complexity-performance trading knob. In this work an adaptive technique to dynamically adjust the group size as a function of the instantaneous operating scenario is presented. It is shown that this adaptivity can bring along important reductions in complexity without compromising error performance.
Scale Congestion Control to Ultra-High Speed Ethernet

Currently, Ethernet is broadly used in LAN, datacenter and enterprise networks, storage networks, high performance computing networks and so on. Along with the popularity of Ethernet comes the requirement of enhancing Ethernet with congestion control. On the other hand, Ethernet speed extends to 40Gbps and 100Gbps recently, and even 400Gbps in the near future. The ultra-high speed requires congestion control algorithms to adapt to the broad changes of bandwidth, and highlights the impacts of small delay by enlarging the bandwidth delay product. The state-of-art standard QCN is heuristically designed for the 1Gbps and 10Gbps Ethernet, and unaware of the challenges accompanying the ultra-high speed. To scale congestion control to ultra-high speed Ethernet, we propose the Adaptive Sliding Mode (ASM) congestion control algorithm, which is simple, stable, has fast and smooth convergence process, can tolerate the impacts of delay and adapt to the wide changes of bandwidth. Real experiments and simulations confirm these good properties and show that ASM outperforms QCN. Designing ASM, we find that the derivative of queue length is helpful to rate adjustment because it reflects the difference between bandwidth and aggregated sending rate. We also argue for enforcing congestion control system staying at the congestion boundary line, along which it automatically slides to stable point. These insights are also valuable to develop other congestion control algorithms in ultra-high speed networks.
Towards formal model of adversarial action in multi-agent systems

Detecting and preventing the adversarial action of an agent with respect to the community of agents can be a serious issue in the design of open multi-agent systems. This task is severely domain dependent and it is hard to find a general solution. This contribution presents a utility based model of adversarial action and analyses few properties of adversarial behavior in multi-agent systems. Potential use and important drawbacks of this model are discussed in the paper.
Investigating visual dominance with a virtual driving task

Most interactive input devices for virtual reality-based simulators are proprietary and expensive. Can they be substituted with standard, inexpensive devices if the virtual representation of the input device looks and acts like the original? Visual dominance theory would appear to support such a possibility. According to this view the visual aspects of the displayed input device within the virtual environment should override the haptic aspects of the real device. We tested this visual dominance theory in a VR power wheelchair simulator scenario comparing standard gaming and proprietary wheelchair joysticks in combinations with their virtual counterparts and measured the effects on driving performance and reported experience. In a study with 48 participants we found significant support for visual dominance effects on driving performance. At the same time, users reported awareness of the presence and change of real joysticks and virtual representations.
miR-146a Inhibits Cell Growth, Cell Migration and Induces Apoptosis in Non-Small Cell Lung Cancer Cells

Aberrant expression of microRNA-146a (miR-146a) has been reported to be involved in the development and progression of various types of cancers. However, its role in non-small cell lung cancer (NSCLC) has not been elucidated. The aim of this study was to investigate the contribution of miR-146a to various aspects of the malignant phenotype of human NSCLCs. In functional experiments, miR-146a suppressed cell growth, induced cellular apoptosis and inhibited EGFR downstream signaling in five NSCLC cell lines (H358, H1650, H1975, HCC827 and H292). miR-146a also inhibited the migratory capacity of these NSCLC cells. On the other hand, miR-146a enhanced the inhibition of cell proliferation by drugs targeting EGFR, including both TKIs (gefitinib, erlotinib, and afatinib) and a monoclonal antibody (cetuximab). These effects were independent of the EGFR mutation status (wild type, sensitizing mutation or resistance mutation), but were less potent compared to the effects of siRNA targeting of EGFR. Our results suggest that these effects of miR-146a are due to its targeting of EGFR and NF-κB signaling. We also found, in clinical formalin fixed paraffin embedded (FFPE) lung cancer samples, that low expression of miR-146a was correlated with advanced clinical TNM stages and distant metastasis in NSCLC (P<0.05). The patients with high miR-146a expression in their tumors showed longer progression-free survival (25.6 weeks in miR-146a high patients vs. 4.8 weeks in miR-146a low patients, P<0.05). miR-146a is therefore a strong candidate prognostic biomarker in NSCLC. Thus inducing miR-146a might be a therapeutic strategy for NSCLC.
Effect of a 12-Month Exercise Intervention on Serum Biomarkers of Angiogenesis in Postmenopausal Women: A Randomized Controlled Trial

Background: Increased physical activity is associated with decreased risk of several types of cancer, but underlying mechanisms are poorly understood. Angiogenesis, in which new blood vessels are formed, is common to adipose tissue formation/remodeling and tumor vascularization. Methods: We examined effects of a 12-month 45 minutes/day, 5 days/week moderate-intensity aerobic exercise intervention on four serum markers of angiogenesis in 173 sedentary, overweight, postmenopausal women, 50 to 75 years, randomized to intervention versus stretching control. Circulating levels of positive regulators of angiogenesis [VEGF, osteopontin (OPN), plasminogen activator inhibitor-1 (PAI-1)], and the negative regulator pigment epithelium-derived factor (PEDF), were measured by immunoassay at baseline and 12 months. Changes were compared using generalized estimating equations, adjusting for baseline levels of analytes and body mass index (BMI). Results: VEGF, OPN, or PAI-1 levels did not differ by intervention arm. Participants randomized to exercise significantly reduced PEDF (−3.7%) versus controls (+3.0%; P = 0.009). Reductions in fat mass were significantly associated with reductions in PAI-1 (Ptrend = 0.03; Ptrend = 0.02) and PEDF (Ptrend = 0.002; Ptrend = 0.01) compared with controls, or to those who gained any fat mass respectively. There was a significant association between decreases in VO2max, and increased reductions in PEDF (Ptrend = 0.03), compared with participants who increased their level of fitness. Conclusions: Fat loss reduces circulating PAI-1 and PEDF. Changes in VO2max are associated with alterations in PEDF, but these associations are complex. Impact: Unexpected reductions in PEDF with decreasing fat mass, and with decreasing VO2max, warrant further study, including examining the effects of different types and intensities of exercise; and role of dietary weight-loss with and without exercise. Cancer Epidemiol Biomarkers Prev; 23(4); 648–57. ©2014 AACR.
Differential Geometric Aspects of Alexandrov Spaces

We summarize the results on the differential geometric structure of Alexandrov spaces developed in [Otsu and Shioya 1994; Otsu 1995; Otsu and Tanoue a]. We discuss Riemannian and second differentiable structure and Jacobi fields on Alexandrov spaces of curvature bounded below or above.
Aberrant crypt foci as precursors in colorectal cancer progression

Colorectal cancer progression originates when accumulated genetic and epigenetic alterations cause genomic instability and a malignant phenotype. Subsequent molecular pathway deregulation leads to histopathologic changes that are clinically evident as aberrant crypt foci (ACF) and visualized by high‐magnification chromoscopic colonoscopy. ACF are biomarkers of increased colorectal cancer risk, particularly those with dysplastic features. Genetic profiling using genomic instability, loss of heterozygosity, and methylation analysis has revealed a minority population of ACF genotypically analogous to cancer. J. Surg. Oncol. 2008;98:207–213. © 2008 Wiley‐Liss, Inc.
Research of Differentiated Services Strategy in Wireless LAN

While introducing on IEEE 802.11MAC layer QoS limitations, we do analyze to the current existing IEEE 802.11 wireless LAN QoS strategy, and proposed a solution: the distinction between based on timeslot adaptive adjustment service strategy, the strategy is able to pull the priority throughput, the rational allocation of channel resources, computer simulations show that the it well realize the throughput differentiated services, improve wireless LAN QoS.