Miracle-dz/UniFAR-FTUs huggingface dataset:
Dynamic user interface distribution for flexible multimodal interaction

The availability of numerous networked interaction devices within smart environments makes the exploitation of these devices for innovative and more natural interaction possible. In our work we make use of TVs with remote controls, picture frames, mobile phones, touch screens, stereos and PCs to create multimodal user interfaces. The combination of the interaction capabilities of the different devices allows to achieve a more suitable interaction for a situation. Changing situations can then require the dynamic redistribution of the created interfaces and the alteration of the used modalities and devices to keep up the interaction. In this paper we describe our approach for dynamically (re-) distributing user interfaces at run-time. A distribution component is responsible for determining the devices for the interaction based on the (changing) environment situation and the user interface requirements. The component provides possibilities to the application developer and to the user to influence the distribution according to their needs. A user interface model describes the interaction and the modality relations according to the CARE properties (Complementarity, Assignment, Redundancy and Equivalency) and a context model gathers and provides information about the environment.
Analytical and Experimental Characterization of Stiffness and Damping in Carbon Nanocoil Reinforced Polymer Composites

This study focuses on understanding the stiffness and damping characteristics of carbon nanocoil (CNC)/polymer composites. To determine the effective elastic and viscoelastic properties of a polymer reinforced with aligned CNCs, the finite element analysis was performed using a three-dimensional unit cell model. The coil morphology of CNCs was examined using a scanning electron microscope. The effects of coil diameter, tube diameter, coil pitch and number of coil turns on the effective properties are discussed. The effective properties of a polymer reinforced with randomly oriented CNCs were also predicted by the results for the unit cell model. The tradeoffs between stiffness and damping characteristics are assessed by changing the volume fraction and geometrical parameters of CNCs. Additionally, experimental measurements of the elastic modulus and the loss factor of the manufactured CNC/polymer composites were carried out by using dynamic mechanical analysis. The predictions were then compared with the experimental results. Furthermore, scanning electron microscopy was performed to observe the fracture surface of CNC/polymer composites.
Automatic synthesis of DUT board circuits for testing of mixed signal ICs

Test development is without doubt the major bottleneck in the product delivery cycle of mixed signal ICs. One of the most time consuming tasks during the test development phase is the design of the DUT board where the IC is to be inserted to run on a mixed signal tester. This paper describes a new methodology of capturing test information for an IC through test module schematics and then using an automatic tool to synthesize the final load board circuitry to be used on mixed signal ATEs. <<ETX>>
Modeling of Axial Magnetic Force and Stiffness of Ring-Shaped Permanent-Magnet Passive Vibration Isolator and Its Vibration Isolating Experiment

Magnetic suspension vibration isolators have attracted more and more attention in the field of semiconductor industry and high precision equipments. A novel ring-shaped permanent-magnet passive vibration isolator is mainly reported in this paper. An analytical expression of axial magnetic force of the isolator is derived and validated by the finite element analysis and experiment. It proves that the analytical expression is efficient. An analytical expression of the axial stiffness of the isolator is deduced by derivative of the axial magnetic force with respect to the axial relative displacement of the inner ring. Furthermore, the parametric study of the axial magnetic force and stiffness are carried out. As a ring-shaped permanent-magnet passive vibration isolator case study, the isolator was constructed by four couples of the ring-shaped permanent magnets. The vibration isolation performance of the isolator was subsequently calculated and tested. The experimental results have shown a good agreement with the calculated ones. It demonstrates that the proposed isolator can realize low-frequency vibration isolation.
Mechanism of Action of the Novel Nickel(II) Complex in Simultaneous Reactivation of the Apoptotic Signaling Networks Against Human Colon Cancer Cells

The aim of this study was to evaluate the cytotoxic potential of a novel nickel(II) complex (NTC) against WiDr and HT-29 human colon cancer cells by determining the IC50 using the standard MTT assay. The NTC displayed a strong suppressive effect on colon cancer cells with an IC50 value of 6.07 ± 0.22 μM and 6.26 ± 0.13 μM against WiDr and HT-29 respectively, after 24 h of treatment. Substantial reduction in the mitochondrial membrane potential and increase in the release of cytochrome c from the mitochondria directed the induction of the intrinsic apoptosis pathway by the NTC. Activation of this pathway was further evidenced by significant activation of caspase 3/7 and 9. The NTC was also shown to activate the extrinsic pathway of apoptosis via activation of caspase-8 which is linked to the suppression of NF-κB translocation to the nucleus. Cell cycle arrest in the G1 phase was confirmed by flow cytometry and up-regulation of glutathione reductase expression was quantified by qPCR. Results of the current work indicates that NTC possess a potent cancer cell abolishing activity by simultaneous induction of intrinsic and extrinsic pathways of apoptosis in colon cancer cell lines.
Optimization of reconfigurable fabric of DSP processor with image processing

In recent scenario, design complexity increases which motivate system designer to innovate continuously. While designing complex system with tight coupling, various block designing is become a choice. The strongly emerging class Coarse-Grained Reconfigurable Architecture (CGRA), is currently receiving due attention having excellent performance as well as flexibility in fabrication. CGRA is having one of the important blocks as reconfigurable array or fabric. In this paper, design of reconfigurable fabric with various combinations of processing element is presented. Also this design is analyze with area, power and delay t achieve optimization of DSP processor using various FPGA.
A Repressor Protein Complex Regulates Leaf Growth in Arabidopsis

PPD2 interacts with KIX8 and KIX9 proteins to regulate the transcription of its target genes, including the CYCD3s, and helps to control final leaf size in Arabidopsis. Cell number is an important determinant of final organ size. In the leaf, a large proportion of cells are derived from the stomatal lineage. Meristemoids, which are stem cell-like precursor cells, undergo asymmetric divisions, generating several pavement cells adjacent to the two guard cells. However, the mechanism controlling the asymmetric divisions of these stem cells prior to differentiation is not well understood. Here, we characterized PEAPOD (PPD) proteins, the only transcriptional regulators known to negatively regulate meristemoid division. PPD proteins interact with KIX8 and KIX9, which act as adaptor proteins for the corepressor TOPLESS. D3-type cyclin encoding genes were identified among direct targets of PPD2, being negatively regulated by PPDs and KIX8/9. Accordingly, kix8 kix9 mutants phenocopied PPD loss-of-function producing larger leaves resulting from increased meristemoid amplifying divisions. The identified conserved complex might be specific for leaf growth in the second dimension, since it is not present in Poaceae (grasses), which also lack the developmental program it controls.
On the feasibility of real-time phone-to-phone 3D localization

High-speed, locational, phone-to-phone (HLPP) games and apps constitute a provocative class of mobile apps that are currently unsupported on commodity mobile devices. This work looks at a key problem for enabling HLPP: a specific variant of the localization problem in which two phones estimate each other's relative positions in 3D space without infrastructure support. Moreover, position estimates should reflect changes due to the phones' possible mobility. We present a solution for achieving high speed 3D continuous localization for phone-to-phone scenarios. Our basic approach uses acoustic cues based on time-of-arrival and power level. It assumes at least two microphones and one speaker per phone, which is common on new smartphones. Accelerometers and digital compasses assist in resolving ambiguous acoustic-only localization. Continuous localization is achieved with the aid of a loose time synchronization protocol and an extended Kalman filter. Experimental results across a range of motion paths show localization resolution to within 13.9 centimeters for 90% of estimates, and to within 4.9 centimeters for 50% of estimates when the phones are several meters apart.
The Basic Study on Machinability of Ceramics in CO 2 Laser Assisted Machining

Abstract ： Machinability of LAM(Laser Assisted Machining) has been studied for ceramics such as Al 2 O 3 , Si 3 N 4 and ZrO 2 by CO 2 laser. It was possible to remove ceramics by PCBN tool because material became softening and deterioratio n by local laser beam irradiation. The advantage of LAM is the ability to produce lar ger material removal rates and tool life. But, for cutting of Al 2 O 3 and ZrO 2 , stage of laser power control was needed owing to thermal shock with high temperature of workpiece by laser power. And when Si 3 N 4 was machined by LAM, N 2 gas spouted from surface of one cause of high temperature. Characteristics of LAM were analyzed using pyrometer, dynamom eter, SEM and EDS to measure temperature of workpiece surface, cutting force, var iation of machining surface and structure of lattice respectively. As the result of this study, it was found that machinability of LAM for ceramics in CO 2 laser and mechanism of LAM was different according to the kind of ceramics because of properties of materials.
Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes

MicroRNAs are posttranscriptional gene regulators that are differentially expressed during various diseases and have been implicated in the underlying pathogenesis. We report here that miR-199a is acutely downregulated in cardiac myocytes on a decline in oxygen tension. This reduction is required for the rapid upregulation of its target, hypoxia-inducible factor (Hif)-1α. Replenishing miR-199a during hypoxia inhibits Hif-1α expression and its stabilization of p53 and, thus, reduces apoptosis. On the other hand, knockdown of miR-199a during normoxia results in the upregulation of Hif-1α and Sirtuin (Sirt)1 and reproduces hypoxia preconditioning. Sirt1 is also a direct target of miR-199a and is responsible for downregulating prolyl hydroxylase 2, required for stabilization of Hif-1α. Thus, we conclude that miR-199a is a master regulator of a hypoxia-triggered pathway and can be exploited for preconditioning cells against hypoxic damage. In addition, the data demonstrate a functional link between 2 key molecules that regulate hypoxia preconditioning and longevity.
Direct Evidence for Wake-Related Increases and Sleep-Related Decreases in Synaptic Strength in Rodent Cortex

Despite evidence that waking is associated with net synaptic potentiation and sleep with depression, direct proof for changes in synaptic currents is lacking in large brain areas such as the cerebral cortex. By recording miniature EPSCs (mEPSCs) from frontal cortex slices of mice and rats that had been awake or asleep, we found that the frequency and amplitude of mEPSCs increased after waking and decreased after sleep, independent of time of day. Recovery sleep after deprivation also decreased mEPSCs, suggesting that sleep favors synaptic homeostasis. Since stronger synapses require more energy, space, and supplies, a generalized renormalization of synapses may be an important function of sleep.
An inpatient lifestyle-change programme improves heart rate recovery in overweight and obese children and adolescents (LOGIC Trial)

Background Impaired heart rate recovery (HRR) is a strong predictor of overall mortality and cardio-metabolic risk. This study aimed at investigating (1) the effect of participation in a lifestyle-change programme for weight loss on HRR in overweight and obese children and (2) potential associations between the changes in one minute HRR (HRR1) and fitness, weight loss and cardio-metabolic risk. Methods The analysis included 429 individuals (169 boys) aged 13.9 ± 2.3 years who participated in an inpatient weight loss programme for four to six weeks. At baseline and the end of the programme clinical investigations were performed, including blood analyses, blood pressure, anthropometry and maximal cycle ergometer exercise testing with continuous heart rate (HR) monitoring. HRR was calculated as the difference between the highest exercising HR and HR at one, three and five minutes post-exercise. Results Average body weight decreased from 90.7 ± 22.5 kg to 81.9 ± 20.0 kg and peak exercise capacity increased from 1.66 ± 0.38 W/kg to 2.05 ± 0.45 W/kg (p < 0.001). Cardio-metabolic risk factors improved (waist circumference, LDL-cholesterol, HOMA insulin ratio, blood pressure; p < 0.05). HDL-cholesterol and triglyceride levels remained unchanged. Compared with baseline, at follow-up the decline in HR was more pronounced (+32%, +18% and +11% for HRR1, HRR3 and HRR5; p < 0.001). Improvements in HRR1 were weakly correlated with changes in exercise capacity (p < 0.05; r < 0.13), but not with changes in body weight and cardio-metabolic risk factors. Conclusions HRR considerably improved after an inpatient weight loss programme in overweight and obese children. This was not associated with improvements in body weight and cardio-metabolic risk; hence HRR would be a valuable addition to cardiovascular risk assessment in this group.
Secure Mechanism for Mobile Web Browsing

The prevailing of mobile network provides increasing web applications and services available on mobile devices. However, most of the websites are developed with limited security consideration, let alone web services for mobile users. Hackers take advantage of the web-based vulnerabilities to inject malicious JavaScript into compromised web pages, and a mobile victim visits the site will be compromised. Current anti-virus software for mobile devices is not adequate to protect mobile users from malicious web pages. Based on our observation, mobile malicious web pages have unusual behaviors for evading detection which makes them different form normal ones. Therefore, we propose a client-side malicious web page detection method based on anomaly behaviors observed from web page analysis. Based on the experimental results, our method can identify malicious web page efficiently and warn the website visitors before browsing.
Understanding how redox modification of the channel protein alters channel structure and function is providing leads for the design of therapeutic interventions that target oxidative stress responses

Calcium plays an integral role in cellular function. It is a well-recognized second messenger necessary for signaling cellular responses, but in excessive amounts can be deleterious to function, causing cell death. The main route by which calcium enters the cytoplasm is either from the extracellular compartment or internal Comprehensive Invited Review ANTIOXIDANTS & REDOX SIGNALING Volume 9, Number 4, 2007 © Mary Ann Liebert, Inc. DOI: 10.1089/ars.2006. 1446 14386Hoo.pgs 1/31/07 3:47 PM Page 409
Design and Evaluation of a Cable-Driven fMRI-Compatible Haptic Interface to Investigate Precision Grip Control

Our hands and fingers are involved in almost all activities of daily living and, as such, have a disproportionately large neural representation. Functional magnetic resonance imaging investigations into the neural control of the hand have revealed great advances, but the harsh MRI environment has proven to be a challenge to devices capable of delivering a large variety of stimuli necessary for well-controlled studies. This paper presents a fMRI-compatible haptic interface to investigate the neural mechanisms underlying precision grasp control. The interface, located at the scanner bore, is controlled remotely through a shielded electromagnetic actuation system positioned at the end of the scanner bed and then through a high stiffness, low inertia cable transmission. We present the system design, taking into account requirements defined by the biomechanics and dynamics of the human hand, as well as the fMRI environment. Performance evaluation revealed a structural stiffness of 3.3 N/mm, renderable forces up to 94 N, and a position control bandwidth of at least 19 Hz. MRI-compatibility tests showed no degradation in the operation of the haptic interface or the image quality. A preliminary fMRI experiment during a pilot study validated the usability of the haptic interface, illustrating the possibilities offered by this device.
Strategies for the identification of disease-related patterns of volatile organic compounds: prediction of paratuberculosis in an animal model using random forests

Modern statistical methods which were developed for pattern recognition are increasingly being used for data analysis in studies on emissions of volatile organic compounds (VOCs). With the detection of disease-related VOC profiles, novel non-invasive diagnostic tools could be developed for clinical applications. However, it is important to bear in mind that not all statistical methods are equally suitable for the investigation of VOC profiles. In particular, univariate methods are not able to discover VOC patterns as they consider each compound separately. The present study demonstrates this fact in practice. Using VOC samples from a controlled animal study on paratuberculosis, the random forest classification method was applied for pattern recognition and disease prediction. This strategy was compared with a prediction approach based on single compounds. Both methods were framed within a cross-validation procedure. A comparison of both strategies based on these VOC data reveals that random forests achieves higher sensitivities and specificities than predictions based on single compounds. Therefore, it will most likely be more fruitful to further investigate VOC patterns instead of single biomarkers for paratuberculosis. All methods used are thoroughly explained to aid the transfer to other data analyses.
The role of cardiorenal biomarkers for risk stratification in the early follow-up after hospitalisation for acute heart failure

Abstract Context: Cardiorenal biomarkers (CBs) predict outcome in acute heart failure (AHF). Objective: To evaluate CBs in early follow-up prognostication. Methods: In 124 AHF patients, levels of CystatinC, NT-proBNP and TroponinI measured five weeks from admission (W5) and relative change from day 2 (D2) were assessed for 6-month prognosis (mortality/HF hospitalization). Results: The combined end-point occurred in 33 patients (27%). D2-, W5-cystatin≥ median, and lack of ≥30%decrease in NT-proBNP were independent predictors of outcome. Additionally, a risk score established from W5 CBs identified patients with very high event rate. Conclusions: CBs at early follow-up of AHF may guide risk stratification.
Individual semicircular canal function in superior and inferior vestibular neuritis

Objective: To examine the concept of selective superior and inferior vestibular nerve involvement in vestibular neuritis by studying the distribution of semicircular canal (SCC) involvement in such patients. Background: Vestibular neuritis was traditionally thought to involve the superior and inferior vestibular nerves. Recent work suggests that in some patients, only the superior nerve is involved. So far there are no reported cases of selective involvement of the inferior vestibular nerve. Methods: The authors measured the vestibuloocular reflex from individual SCC at natural head accelerations using the head impulse test. The authors studied 33 patients with acute unilateral peripheral vestibulopathy, including 29 with classic vestibular neuritis and 4 with simultaneous ipsilateral hearing loss, 18 healthy subjects and 15 surgical unilateral vestibular deafferented patients. Results: In patients with preserved hearing, eight had deficits in all three SCC, suggesting involvement of the superior and inferior vestibular nerves. Twenty-one had a lateral SCC deficit or a combined lateral and anterior SCC deficit consistent with selective involvement of the superior vestibular nerve. Two patients with ipsilateral hearing loss had normal caloric responses and an isolated posterior SCC deficit on impulsive testing. The authors propose that these two patients had a selective loss of inferior vestibular nerve function. Conclusion: Vestibular neuritis can affect the superior and inferior vestibular nerves together or can selectively affect the superior vestibular nerve.
White Blood Cell Count in Women: Relation to Inflammatory Biomarkers, Haematological Profiles, Visceral Adiposity, and Other Cardiovascular Risk Factors

The role of white blood cell (WBC) count in pathogenesis of diabetes, cardiovascular disease, and obesity-related disorders has been reported earlier. Recent studies revealed that higher WBC contributes to atherosclerotic progression and impaired fasting glucose. However, it is unknown whether variations in WBC and haematologic profiles can occur in healthy obese individuals. The aim of this study is to further evaluate the influence of obesity on WBC count, inflammatory biomarkers, and metabolic risk factors in healthy women to establish a relationship among variables analyzed. The sample of the present study consisted of 84 healthy women with mean age of 35.56±6.83 years. They were categorized into two groups based on their body mass index (BMI): obese group with BMI >30 kg/m2 and non-obese group with BMI <30 kg/m2. We evaluated the relationship between WBC and platelet count (PLT) with serum interleukin 6 (IL-6), C-reactive protein (CRP), angiotensin Π (Ang Π), body fat percentage (BF %), waist-circumference (WC), and lipid profile. WBC, PLT, CRP, and IL-6 in obese subjects were significantly higher than in non-obese subjects (p< 0.05). The mean WBC count in obese subjects was 6.4±0.3 (×109/L) compared to 4.4±0.3 (×109/L) in non-obese subjects (p=0.035). WBC correlated with BF% (r=0.31, p=0.004), CRP (r=0.25, P=0.03), WC (r=0.22, p=0.04), angiotensin Π (r=0.24, p=0.03), triglyceride (r=0.24, p=0.03), and atherogenic index of plasma (AIP) levels (r=0.3, p=0.028) but not with IL-6. Platelet count was also associated with WC and waist-to-hip ratio (p<0.05). Haemoglobin and haematocrit were in consistent relationship with LDL-cholesterol (p<0.05). In conclusion, obesity was associated with higher WBC count and inflammatory parameters. There was also a positive relationship between WBC count and several inflammatory and metabolic risk factors in healthy women.