Miracle-dz/UniFAR-FTUs huggingface dataset:
Digital Transformation: An Exploring Barriers and Challenges Practice of Artificial Intelligence in Manufacturing Firms in Malaysia

Digital transformation has become very crucial in global market. Digital technologies have revolutionized the way industries operate, introducing the concept of “Industry 4.0” or the “smart factory”. Digital technologies have substantially transformed the business and society, bringing fundamental changes through the new emerging approaches of the circular and sharing economy. Artificial intelligence (AI) is now become an essential part in the manufacturing industry to enhance the performance and boost the demand and productivity in the manufacturing firms. However, there are some barriers and challenges face by the manufacturing firms in implementing the AI due to the infancy stage of AI in Malaysia such as lack of talent, lack of incentive and innovation. Therefore, the purpose of this study is to identify the barriers and challenges in implementing AI. In this paper, managers from the manufacturing companies were selected as respondents based on Federal Manufacturing Malaysia Directory. The questionnaires are distributed to the respondents by using the online survey. A total of 93 questionnaires was collected with feedback rate, 23.3%. Descriptive analysis is used to identify the barriers and challenges. The highest level for barriers of AI is lack of talent. The highest level for challenges is no experts in company. This research provide input for manufacturing companies to improve the barriers and challenges for future improvement in implementing AI.
Diffusion length calculations for one-speed neutrons in a slab with backward, forward and linear anisotropic scattering

Abstract The diffusion lengths for one-speed neutrons spreading in a uniform homogeneous slab with backward, forward and linear anisotropic scattering are calculated by using first order approximation of the Chebyshev polynomials of first kind, i. e. T1 method. The method is applied to neutron transport equation by expanding first the neutron angular flux in terms of the Chebyshev polynomials of first kind, and then diffusion lengths for one-speed neutrons are determined for various values of the collision and anisotropy parameters. Numerical results obtained from the present method are tabulated in tables together with the ones already presented in literature.
A Blockchain Approach of Model Architecture for Crowdsourcing Design Services under the Context of Social Manufacturing

Crowdsourcing design is generally monitored by the platform. However, the traditional crowdsourcing platforms face problems such as centralization, lack of credibility and vulnerability to single point of failure. Under the context of social manufacturing, how to address these potential issues has both research and substantial value. In this paper, we introduce decentralized blockchain technology for crowdsourcing service systems and propose a method to manage and control the process of crowdsourcing design services. We depict complex crowdsourcing logic by smart contract. The process of crowdsourcing design is not dependent on any third party. It is decentralized, tamper-proof, traceable and protects the privacy of users to a certain extent. We implement this crowdsourcing design system on a specific blockchain test network to experiment and test its functionalities. Experiment results show the feasibility and usability of our crowdsourcing design system. In the future, we will further improve the algorithmic logic of smart contracts so that they can run stably and securely in a complex node network environment.
Breakthroughs came from extensive explorations of the sea oor after World

Abhinaba Das is a KVPY scholar currently studying at the Indian Institute of Science, Bangalore. A unique attribute of Earth is the presence of plate tectonics. Not only does it give rise to continents, mountain chains, and ocean basins but also promotes a high level of biodiversity. It is the reason for the formation of the so-called ‘Paci c Ring of Fire’ – a belt of intense volcanic activity and a large number of earthquakes surrounding the Paci c ocean. But what drives the plate motion? Did Earth always have plate tectonics? These are some fascinating geoscienti c questions. In trying to answer these questions, an effort is made to impress upon the reader the vast ocean of uncertainty, and hence the opportunity, in the eld of Earth and Planetary Sciences. To make it more engaging, the article provides a peek into the long process which culminated in the present-day theory of plate tectonics on Earth. While the rst half of the article focuses on subduction and its cause, the second half summarizes a recent nding made on the surface of Europa. In view of readability across disciplines, the complex subject details are kept to bare minimum.
Kinematics of globular cluster systems in galaxy mergers

Abstract We use numerical simulations to study how the spatial distribution and kinematics of globular cluster systems (GCS) are affected by galaxy mergers. Each progenitor galaxy is given a GCS modeled after the Galactic GCS. We then study how a major merger affects the spatial distribution and kinematics of the GCS. Here we present our methodology. Future work will investigate the effects of varying galaxy parameters, merger orbital parameters, and initial GCS number density profile and kinematics. We hope to be able to extract information about the merger history of a galaxy from observations of its GCS spatial distribution and kinematics.
A spectral analysis of the Earth's angular momentum budget

Changes in the circulation of the earth's atmosphere cause fluctuations in the length of day (LOD) by exchanging angular momentum with the surface of the earth. In this paper we examine the earth's polar angular momentum budget using earth rotation data from optical astrometry and lunar laser ranging together with simultaneous estimates of the atmospheric angular momentum Matm derived from meteorological data. The atmospheric excitation can explain most of the observed LOD fluctuations at periods between 700 and 40 days. The observed Matm spectral power is proportional to the inverse frequency squared for periods between 1 year and 3 days and flattens out at higher frequencies. The LOD and Matm spectra are very similar except at periods of <40 days, where the LOD measurement noise dominates. The Matm - LOD coherence is highly significant between periods of 700 and 40 days. There is no evidence for phase shifts between the Matm and LOD data at periods between 600 and 40 days. A broad peak is clearly evident at periods of 40–60 days in the spectra of all three time series. The LOD data have a long-term drift, not matched by the Matm data, that is probably the result of a core-mantle angular momentum exchange. There are significant imbalances in the angular momentum budget. Most of the seasonal imbalance can be attributed to the effects of systematic errors in the meteorological data, but some of this discrepancy may be caused by exchanges of angular momentum with the oceans. The semiannual, monthly, and fortnightly tidal variations in the earth rotation were detected, and the observed amplitudes of these variations are consistent with theoretical estimates.
Three-dimensional boundary-layer instability and separation induced by small-amplitude streamwise vorticity in the upstream flow

We consider the effects of a small-amplitude, steady, streamwise vorticity field on the flow over an infinitely thin flat plate in an otherwise uniform stream. We show how the initially linear perturbation, ultimately leads to a small-amplitude but nonlinear cross-flow far downstream from the leading edge. This motion is imposed on the boundary-layer flow and eventually causes the boundary layer to separate. The streamwise velocity profiles within the boundary layer become inflexional in localized spanwise regions just upstream of the separation point. The flow in these regions is therefore susceptible to rapidly growing inviscid instabilities.
A metabolomic platform to identify and quantify polyphenols in coffee and related species using liquid chromatography mass spectrometry

Introduction Products of plant secondary metabolism, such as phenolic compounds, flavonoids, alkaloids, and hormones, play an important role in plant growth, development, stress resistance. The plant family Rubiaceae is extremely diverse and abundant in Central America and contains several economically important genera, e.g. Coffea and other medicinal plants. These are known for the production of bioactive polyphenols (e.g. caffeine and quinine), which have had major impacts on human society. The overall goal of this study was to develop a high-throughput workflow to identify and quantify plant polyphenols. Methods First, a method was optimized to extract over 40 families of phytochemicals. Then, a high-throughput metabolomic platform has been developed to identify and quantify 184 polyphenols in 15 min. Results The current metabolomics study of secondary metabolites was conducted on leaves from one commercial coffee variety and two wild species that also belong to the Rubiaceae family. Global profiling was performed using liquid chromatography high-resolution time-of-flight mass spectrometry. Features whose abundance was significantly different between coffee species were discriminated using statistical analysis and annotated using spectral databases. The identified features were validated by commercially available standards using our newly developed liquid chromatography tandem mass spectrometry method. Discussion Caffeine, trigonelline and theobromine were highly abundant in coffee leaves, as expected. Interestingly, wild Rubiaceae leaves had a higher diversity of phytochemicals in comparison to commercial coffee: defense-related molecules, such as phenylpropanoids (e.g., cinnamic acid), the terpenoid gibberellic acid, and the monolignol sinapaldehyde were found more abundantly in wild Rubiaceae leaves.
MORE ON PAPERFOLDING

It is a common knowledge that folding a sheet of paper yields a straight line. We start our discussion of paperfolding with a mathematical explanation of this phenomenon. The model for a paper sheet is a piece of the plane; folding is an isometry of the part of the plane on one side of the fold to another, the fold being the curve of fixed points of this isometry (see Figure 1). The statement is that this curve is straight, that is, has zero curvature.
Whole genome sequencing of Clarireedia aff. paspali reveals potential pathogenesis factors in Clarireedia species, causal agents of dollar spot in turfgrass

Dollar spot is one of the most damaging diseases in turfgrass, reducing its quality and playability. Two species, Clarireedia monteithiana and C. jacksonii (formerly Sclerotinia homoeocarpa) have been reported so far in the United States To study the Clarireedia genome, two isolates H2 and H3, sampled from seashore paspalum in Hawaii in 2019 were sequenced via Illumina paired-end sequencing by synthesis technology and PacBio SMRT sequencing. Both isolates were identified as C. aff. paspali, a novel species in the United States Using short and long reads, C. aff. paspali H3 contained 193 contigs with 48.6 Mbp and presented the most completed assembly and annotation among Clarireedia species. Out of the 13,428 protein models from AUGUSTUS, 349 cytoplasmic effectors and 13 apoplastic effectors were identified by EffectorP. To further decipher Clarireedia pathogenicity, C. aff. paspali genomes (H2 and H3), as well as available C. jacksonii (LWC-10 and HRI11), C. monteithiana (DRR09 and RB-19) genomes were screened for fifty-four pathogenesis determinants, previously identified in S. sclerotiorum. Seventeen orthologs of pathogenicity genes have been identified in Clarireedia species involved in oxalic acid production (pac1, nox1), mitogen-activated protein kinase cascade (pka1, smk3, ste12), appressorium formation (caf1, pks13, ams2, rgb1, rhs1) and glycolytic pathway (gpd). Within these genes, 366 species-specific SNPs were recorded between Clarireedia species; twenty-eight were non-synonymous and non-conservative. The predicted protein structure of six of these genes showed superimposition of the models among Clarireedia spp. The genomic variations revealed here could potentially lead to differences in pathogenesis and other physiological functions among Clarireedia species.
Shenxiong glucose injection inhibits oxidative stress and apoptosis to ameliorate isoproterenol-induced myocardial ischemia in rats and improve the function of HUVECs exposed to CoCl2

Background: Shenxiong Glucose Injection (SGI) is a traditional Chinese medicine formula composed of ligustrazine hydrochloride and Danshen (Radix et rhizoma Salviae miltiorrhizae; Salvia miltiorrhiza Bunge, Lamiaceae). Our previous studies and others have shown that SGI has excellent therapeutic effects on myocardial ischemia (MI). However, the potential mechanisms of action have yet to be elucidated. This study aimed to explore the molecular mechanism of SGI in MI treatment. Methods: Sprague-Dawley rats were treated with isoproterenol (ISO) to establish the MI model. Electrocardiograms, hemodynamic parameters, echocardiograms, reactive oxygen species (ROS) levels, and serum concentrations of cardiac troponin I (cTnI) and cardiac troponin T (cTnT) were analyzed to explore the protective effect of SGI on MI. In addition, a model of oxidative damage and apoptosis in human umbilical vein endothelial cells (HUVECs) was established using CoCl2. Cell viability, Ca2+ concentration, mitochondrial membrane potential (MMP), apoptosis, intracellular ROS, and cell cycle parameters were detected in the HUVEC model. The expression of apoptosis-related proteins (Bcl-2, Caspase-3, PARP, cytoplasmic and mitochondrial Cyt-c and Bax, and p-ERK1/2) was determined by western blotting, and the expression of cleaved caspase-3 was analyzed by immunofluorescence. Results: SGI significantly reduced ROS production and serum concentrations of cTnI and cTnT, reversed ST-segment elevation, and attenuated the deterioration of left ventricular function in ISO-induced MI rats. In vitro, SGI treatment significantly inhibited intracellular ROS overexpression, Ca2+ influx, MMP disruption, and G2/M arrest in the cell cycle. Additionally, SGI treatment markedly upregulated the expression of anti-apoptotic protein Bcl-2 and downregulated the expression of pro-apoptotic proteins p-ERK1/2, mitochondrial Bax, cytoplasmic Cyt-c, cleaved caspase-3, and PARP. Conclusion: SGI could improve MI by inhibiting the oxidative stress and apoptosis signaling pathways. These findings provide evidence to explain the pharmacological action and underlying molecular mechanisms of SGI in the treatment of MI.
The Temporal Voice Areas are not “just” Speech Areas

The Temporal Voice Areas (TVAs) respond more strongly to speech sounds than to non-speech vocal sounds, but does this make them Temporal “Speech” Areas? We provide a perspective on this issue by combining univariate, multivariate, and representational similarity analyses of fMRI activations to a balanced set of speech and non-speech vocal sounds. We find that while speech sounds activate the TVAs more than non-speech vocal sounds, which is likely related to their larger temporal modulations in syllabic rate, they do not appear to activate additional areas nor are they segregated from the non-speech vocal sounds when their higher activation is controlled. It seems safe, then, to continue calling these regions the Temporal Voice Areas.
Comparison of velopharyngeal morphology of two palatoplasty techniques in patients with hard and soft cleft palate

Purpose The study aims to compare the velopharyngeal morphology of hard and soft cleft palate (HSCP) patients after Furlow and Sommerlad palatoplasty. Patients and methods A total of 51 patients (20 cases in Furlow palatoplasty group, 16 cases in Sommerlad palatoplasty group and 15 normal children in the control group) were included in our study. Velopharyngeal function and speech outcomes of patients with HSCP who had either Furlow palatoplasty or Sommerlad palatoplasty for cleft palate repair were evaluated by perceptual speech assessment (PSA), lateral cephalometric radiographs and nasopharyngoscopy. To assess velopharyngeal morphology of patients treated with two techqiques, we analyzed measurements such as velar length, pharyngeal depth, and the Adequate ratio (the ratio of velar length to pharyngeal depth). Furthermore, skeletal landmarks including cranial base, cervical vertebrae, posterior nasal spine which were defined as the pharyngeal triangle were measured. Finally, the position of the point U relative to the pharyngeal triangle were compared. Results Velopharyngeal closure (VPC) rate in Furlow palatoplasty group accounted for 90%, while that in Sommerlad palatoplasty group was 81.3%. PSA of the former group was significantly better than that of the latter group (P < 0.05). Velar length, pharyngeal depth and the Adequate ratio (1.37 ± 0.14 vs. 1.41 ± 0.15) were comparable between the Furlow group and control group (P > 0.05), while Sommerlad group had a shorter velar length, deeper pharyngeal depth and a smaller Adequate ratio (1.20 ± 0.18) compared to the above two groups (P < 0.05). Furhermore, the point U of Sommerlad group in the pharyngeal triangle was higher than that of the other two groups. Conclusions In the treatment modality of patients with HSCP, both Furlow palatoplasty and Sommerlad palatoplasty seem to be effective. Furlow palatoplasty appears to have velopharyngeal morphology similar to normal control group. , while Sommerlad group shows a shorter velar length, deeper pharyngeal depth and a smaller Adequate ratio
Interplay between integrins and cadherins to control bone differentiation upon BMP-2 stimulation

Introduction: Upon BMP-2 stimulation, the osteoblastic lineage commitment in C2C12 myoblasts is associated with a microenvironmental change that occurs over several days. How does BMP-2 operate a switch in adhesive machinery to adapt to the new microenvironment and to drive bone cell fate is not well understood. Here, we addressed this question for BMP-2 delivered either in solution or physically bound of a biomimetic film, to mimic its presentation to cells via the extracellular matrix (ECM). Methods: Biommetics films were prepared using a recently developed automated method that enable high content studies of cellular processes. Comparative gene expressions were done using RNA sequencing from the encyclopedia of the regulatory elements (ENCODE). Gene expressions of transcription factors, beta chain (1, 3, 5) integrins and cadherins (M, N, and Cad11) were studied using quantitative PCR. ECM proteins and adhesion receptor expressions were also quantified by Western blots and dot blots. Their spatial organization in and around cells was studied using immuno-stainings. The individual effect of each receptor on osteogenic transcription factors and alkaline phosphatase expression were studied using silencing RNA of each integrin and cadherin receptor. The organization of fibronectin was studied using immuno-staining and quantitative microscopic analysis. Results: Our findings highlight a switch of integrin and cadherin expression during muscle to bone transdifferentiation upon BMP-2 stimulation. This switch occurs no matter the presentation mode, for BMP-2 presented in solution or via the biomimetic film. While C2C12 muscle cells express M-cadherin and Laminin-specific integrins, the BMP-2-induced transdifferentiation into bone cells is associated with an increase in the expression of cadherin-11 and collagen-specific integrins. Biomimetic films presenting matrix-bound BMP-2 enable the revelation of specific roles of the adhesive receptors depending on the transcription factor. Discussion: While β3 integrin and cadherin-11 work in concert to control early pSMAD1,5,9 signaling, β1 integrin and Cadherin-11 control RunX2, ALP activity and fibronectin organization around the cells. In contrast, while β1 integrin is also important for osterix transcriptional activity, Cadherin-11 and β5 integrin act as negative osterix regulators. In addition, β5 integrin negatively regulates RunX2. Our results show that biomimetic films can be used to delinate the specific events associated with BMP-2-mediated muscle to bone transdifferentiation. Our study reveals how integrins and cadherins work together, while exerting distinct functions to drive osteogenic programming. Different sets of integrins and cadherins have complementary mechanical roles during the time window of this transdifferentiation.
Endoscopic mucosal electrodes: New directions for recording and regulating gastric myoelectric activity

With the gradual deepening of the study of gastric motility disorders, people increasingly realize that gastric myoelectric activity plays an important role in coordinating gastric function. This article introduces the advantages of endoscopic mucosal electrodes compared with traditional electrodes. Several different types of mucosal electrodes and how to fix the electrodes by endoscope are introduced. Endoscopic mucosal electrodes can record and regulate gastric myoelectric activity, which has great value in the study of gastric motility. Endoscopic mucosal electrode technique refers to the fixation of the electrode in the designated part of the gastric mucosa by endoscope. Through endoscopic mucosal electrodes, on the one hand, we can record gastric myoelectric activity, on the other hand, we can carry out gastric electrical stimulation to interfere with gastric rhythm. Endoscopic mucosal electrodes have higher accuracy than traditional cutaneous electrodes, less trauma and lower cost than serosal electrodes. Endoscopic mucosal electrodes have a good application prospect for diseases such as gastroparesis and obesity.
Whole-genome sequencing of SARS-CoV-2 isolates from symptomatic and asymptomatic individuals in Tanzania

Background Coronavirus Disease-2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) accounts for considerable morbidity and mortality globally. Paucity of SARS-CoV-2 genetic data from Tanzania challenges in-country tracking of the pandemic. We sequenced SARS-CoV-2 isolated in the country to determine circulating strains, mutations and phylogenies and finally enrich international genetic databases especially with sequences from Africa. Methods This cross-sectional study utilized nasopharyngeal swabs of symptomatic and asymptomatic adults with positive polymerase chain reaction tests for COVID-19 from January to May 2021. Viral genomic libraries were prepared using ARTIC nCoV-2019 sequencing protocol version three. Whole-genome sequencing (WGS) was performed using Oxford Nanopore Technologies MinION device. In silico genomic data analysis was done on ARTIC pipeline version 1.2. 1 using ARTIC nCoV-2019 bioinformatics protocol version 1.1. 0. Results Twenty-nine (42%) out of 69 samples qualified for sequencing based on gel electrophoretic band intensity of multiplex PCR amplicons. Out of 29 isolates, 26 were variants of concern [Beta (n = 22); and Delta (n = 4)]. Other variants included Eta (n = 2) and B.1. 530 (n = 1). We found combination of mutations (S: D80A, S: D215G, S: K417N, ORF3a: Q57H, E: P71L) in all Beta variants and absent in other lineages. The B.1. 530 lineage carried mutations with very low cumulative global prevalence, these were nsp13:M233I, nsp14:S434G, ORF3a:A99S, S: T22I and S: N164H. The B.1. 530 lineage clustered phylogenetically with isolates first reported in south-east Kenya, suggesting regional evolution of SARS-CoV-2. Conclusion We provide evidence of existence of Beta, Delta, Eta variants and a locally evolving lineage (B.1.530) from samples collected in early 2021 in Tanzania. This work provides a model for ongoing WGS surveillance that will be required to inform on emerging and circulating SARS-CoV-2 diversity in Tanzania and East Africa.