Miracle-dz/UniFAR-FTUs huggingface dataset:
Serial measurements of lymphocytes, D-dimer, LDH, and CRP do not improve the ability to predict COVID-19 adverse outcomes

Objective We evaluated the discriminatory ability of variations in lymphocyte, D-dimer, C-reactive protein (CRP), and lactate dehydrogenase (LDH) serum levels at 48 to 72 hours of hospitalization compared with baseline measurements to predict unfavorable clinical outcomes in patients with COVID-19. Methods We analyzed diagnostic test results based on a retrospective cohort to determine the ability of variations (gradients or ratios) in patients’ lymphocyte, D-dimer, CRP, and LDH serum levels taken 48 to 72 hours after hospital admission to predict adverse outcomes such as death, mechanical ventilation, or intensive care unit (ICU) admission developing. Results Among 810 patients (56.1% men, age 61.6 ± 16.2 years), 37.5% had at least one adverse outcome; 28.2% required ICU admission, 26.5% required mechanical ventilation, and 19.4% died during hospitalization. In comparing baseline measurements with measurements at 48 to 72 hours, D-dimer, lymphocyte delta, LDH, and CRP had similar discriminatory ability (area under the receiver operating characteristic curve [AUC] 0.57 vs. 0.56, 0.53 vs. 0.57, 0.64 vs. 0.66, and 0.62 vs. 0.65, respectively). Conclusions Measuring serum risk markers upon hospital admission can be used to evaluate risk of adverse outcomes in hospitalized patients with COVID-19. Repeating these measurements at 48 to 72 hours does not improve discriminatory ability.
Ethics positions of nursing students in clinical decision-making

Background Ethics positions, consisting of the two fundamental dimensions of idealism and relativism, influence individuals’ decision-making significantly. Particularly in an applied field such as nursing, the ethics positions of nurses can play a significant role in clinical decisions. Therefore, it is important to know the factors affecting the ethics positions of nurses in clinical decision-making. Aim The aim of the study is to examine the factors affecting the ethics positions of nursing students in clinical decision-making. Research design This is a two-phase sequential explanatory mixed methods study designed in accordance with the COREQ criteria. A participant Information Form and the Ethics Position Questionnaire were used to collect quantitative data. Qualitative data were obtained through focus group interviews. Ethical considerations This study was conducted after receiving written permission from X University Ethics Board. Additionally, permission was obtained from the participating nursing faculty. Participants Among the fourth-year nursing students, 180 students participated in the quantitative phase and 30 students in the qualitative phase of the study. Results The quantitative data analysis showed that the idealism sub-dimension mean scores of the participants were higher than the relativism sub-dimension mean scores. The analysis of the qualitative data resulted in four main themes that influence participants’ ethics positions in clinical decision-making: (1) attitudes of role models in clinical practice (staff nurses/mentors/lecturers), (2) resources related to clinical practice (labs, hospitals/classrooms), (3) health system (hospital policies/school policies), and (4) personal differences (act with emotion/act with logic). Conclusion The results showed that the health system, role models in the clinic, personal differences, and skill-related resources affect the ethics positions of nursing students in clinical decision-making. In this regard, awareness can be raised by providing training to nursing students by academic instructors on ethics positions and the factors that are determined to affect ethics positions in clinical decision-making.
Perioperative adverse cardiac events and mortality after non-cardiac surgery: a multicenter study

Background Perioperative adverse cardiac events (PACE), a composite of myocardial infarction, coronary revascularization, congestive heart failure, arrhythmic attack, acute pulmonary embolism, cardiac arrest, and stroke during 30-day postoperative period, is associated with long-term mortality, but with limited clinical evidence. We compared long-term mortality with PACE using data from nationwide multicenter electronic health records. Methods Data from 7 hospitals, converted to Observational Medical Outcomes Partnership Common Data Model, were used. We extracted records of 277,787 adult patients over 18 years old undergoing non-cardiac surgery for the first time at the hospital and had medical records for more than 180 days before surgery. We performed propensity score matching and then an aggregated meta‑analysis. Results After 1:4 propensity score matching, 7,970 patients with PACE and 28,807 patients without PACE were matched. The meta‑analysis showed that PACE was associated with higher one-year mortality risk (hazard ratio [HR]: 1.33, 95% CI [1.10, 1.60], P = 0.005) and higher three-year mortality (HR: 1.18, 95% CI [1.01, 1.38], P = 0.038). In subgroup analysis, the risk of one-year mortality by PACE became greater with higher-risk surgical procedures (HR: 1.20, 95% CI [1.04, 1.39], P = 0.020 for low-risk surgery; HR: 1.69, 95% CI [1.45, 1.96], P < 0.001 for intermediate-risk; and HR: 2.38, 95% CI [1.47, 3.86], P = 0.034 for high-risk). Conclusions A nationwide multicenter study showed that PACE was significantly associated with increased one-year mortality. This association was stronger in high-risk surgery, older, male, and chronic kidney disease subgroups. Further studies to improve mortality associated with PACE are needed.
Ecological interactions of sand flies, hosts, and Leishmania panamensis in an endemic area of cutaneous leishmaniasis in Colombia

Background The transmission dynamics of leishmaniasis are complex. There is also a lack of information about the ecological relationships between the vector/host/parasite at a more local and specific level. The Andean region concentrates more than 50% of Colombia’s cutaneous leishmaniasis (CL) cases. The study of the ecological interactions of sand flies through the identification of blood sources has provided information on the female’s opportunistic behavior, feeding on various hosts. Therefore, this study aimed to determine sand flies’ ecological interactions with Leishmania parasites and their blood sources in an endemic area of CL. Results A total of 4,621 sand flies were collected, comprising 20 species, in which the most abundant were Nyssomyia yuilli yuilli (55.4%), Psychodopygus ayrozai (14.5%) and Ps. panamensis (13.4%). Sequences of 12S gene fragment were analyzed using the BLASTn search tool. Blood-meal source identification was successfully performed for 47 sand flies, detecting seven vertebrate species, human and armadillo being the most frequent. Leishmania DNA was amplified in four female pools, constituted by Ny. yuilli yuilli and Ps. ayrozai, and the identification through RFLP detected Leishmania (Viannia) panamensis in the positive pools. Conclusions The interactions between the sand fly species, local mammalian fauna and the Leishmania parasite in this active focus of CL, provide evidence of the potential role of two different species in the maintenance of the parasite transmission, important information for the understanding of the ecoepidemiology and transmission dynamics of the disease in Andean endemic areas. However its necessary further evaluations of the vector and host competence in the transmission and maintenance of Leishmania spp, in these complex and diverse areas.
Current status and future trends of reconstructing a vascularized tissue-engineered trachea

ABSTRACT Alternative treatment of long tracheal defects remains one of the challenges faced by thoracic surgeons. Tissue engineering has shown great potential in addressing this regenerative medicine conundrum and the technology to make tracheal grafts using this technique is rapidly maturing, leading to unique therapeutic approaches. However, the clinical application of tissue-engineered tracheal implants is limited by insufficient revascularization. Among them, realizing the vascularization of a tissue-engineered trachea is the most challenging problem to overcome. To achieve long-term survival after tracheal transplantation, an effective blood supply must be formed to support the metabolism of seeded cells and promote tissue healing and regeneration. Otherwise, repeated infection, tissue necrosis, lumen stenosis lack of effective epithelialization, need for repeated bronchoscopy after surgery, and other complications will be inevitable and lead to graft failure and a poor outcome. Here we review and analyze various tissue engineering studies promoting angiogenesis in recent years. The general situation of reconstructing a vascularized tissue-engineered trachea, including current problems and future development trends, is elaborated from the perspectives of seed cells, scaffold materials, growth factors and signaling pathways, surgical interventions in animal models and clinical applications. This review also provides ideas and methods for the further development of better biocompatible tracheal substitutes in the future.
CBT for difficult-to-treat depression: self-regulation model.

BACKGROUND Cognitive behavioural therapy (CBT) is an effective treatment for depression but a significant minority of clients do not complete therapy, do not respond to it, or subsequently relapse. Non-responders, and those at risk of relapse, are more likely to have adverse childhood experiences, early-onset depression, co-morbidities, interpersonal problems and heightened risk. This is a heterogeneous group of clients who are currently difficult to treat. AIM The aim was to develop a CBT model of depression that will be effective for difficult-to-treat clients who have not responded to standard CBT. METHOD The method was to unify theory, evidence and clinical strategies within the field of CBT to develop an integrated CBT model. Single case methods were used to develop the treatment components. RESULTS A self-regulation model of depression has been developed. It proposes that depression is maintained by repeated interactions of self-identity disruption, impaired motivation, disengagement, rumination, intrusive memories and passive life goals. Depression is more difficult to treat when these processes become interlocked. Treatment based on the model builds self-regulation skills and restructures self-identity, rather than target negative beliefs. A bespoke therapy plan is formed out of ten treatment components, based on an individual case formulation. CONCLUSIONS A self-regulation model of depression is proposed that integrates theory, evidence and practice within the field of CBT. It has been developed with difficult-to-treat cases as its primary purpose. A case example is described in a concurrent article (Barton et al., 2022) and further empirical tests are on-going.
Neuroticism and Adolescent Problematic Mobile Social Media Use: A Moderated Mediation Model

Abstract Although previous studies have confirmed the influence of neuroticism on problematic mobile social media use, mechanisms underlying this relation have not been well-understood. The present study investigated the mediating effect of self-control, as well as the moderating role of family socioeconomic status (FSES). A total of 1146 adolescents’ data (Mage = 16.11, SDage = 0.97, 498 boys) were collected. Participants completed questionnaires about neuroticism, self-control, problematic mobile social media use, and FSES. The moderated mediation analysis showed that self-control mediated the positive association between neuroticism and problematic mobile social media use. In addition, FSES moderated the negative relation between self-control and problematic mobile social media use. Specifically, compared with adolescents in low FSES, the association between self-control and problematic mobile social media use was stronger for adolescents in high FSES. This study advanced our understanding of the development of problematic mobile social media use by revealing the potential mechanism between adolescent neuroticism and problematic mobile social media use.
A logic of probability, with application to the foundations of statistics

A simple example shows that the classical theory of probability implies more than one can deduce via Kolmogorov's calculus of probability. Developing Dawid's ideas I propose a new calculus of probability which is free from this drawback. This calculus naturally leads to a new interpretation of probability. I argue that attempts to create a general empirical theory of probability should be abandoned and we should content ourselves with the logic of probability establishing relations between probabilistic theories and observations. My approach to the logic of probability is based on a variant of Ville's principle of the excluded gambling strategy
Trafficking of oxidative stress-generated lipid hydroperoxides: pathophysiological implications

Abstract Lipid hydroperoxides (LOOHs) are reactive intermediates that arise during peroxidation of unsaturated phospholipids, glycolipids and cholesterol in biological membranes and lipoproteins. Non-physiological lipid peroxidation (LPO) typically occurs under oxidative stress conditions associated with pathologies such as atherogenesis, neurodegeneration, and carcinogenesis. As key intermediates in the LPO process, LOOHs are susceptible to one-electron versus two-electron reductive turnover, the former exacerbating membrane or lipoprotein damage/dysfunction and the latter diminishing it. A third possible LOOH fate is translocation to an acceptor membrane/lipoprotein, where one- or two-electron reduction may then ensue. In the case of cholesterol (Ch)-derived hydroperoxides (ChOOHs), translocation can be specifically stimulated by StAR family trafficking proteins, which are normally involved in Ch homeostasis and Ch-mediated steroidogenesis. In this review, we discuss how these processes can be impaired by StAR-mediated ChOOH and Ch co-trafficking to mitochondria of vascular macrophages and steroidogenic cells, respectively. The protective effects of endogenous selenoperoxidase, GPx4, are also discussed. This is the first known example of detrimental ChOOH transfer via a natural Ch trafficking pathway and inhibition thereof by GPx4.
Real-World First-Line Use of Pertuzumab With Different Taxanes for Human Epidermal Growth Factor Receptor 2–Positive Metastatic Breast Cancer: A Comparative Effectiveness Study Using US Electronic Health Records

PURPOSE On the basis of the results from CLEOPATRA, pertuzumab plus trastuzumab and chemotherapy is the first-line standard of care for human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC). However, discrepancies have been reported between clinical trial and real-world outcomes. We report real-world outcomes for patients with HER2-positive MBC treated with first-line pertuzumab plus trastuzumab and a taxane in routine clinical practice in the United States. METHODS A retrospective analysis was conducted using electronic health record-derived deidentified data from the Flatiron Health database. Patients were grouped according to the first taxane received (paclitaxel/nab-paclitaxel or docetaxel). Median real-world progression-free survival (rwPFS) and overall survival (rwOS) was estimated using Kaplan-Meier methodology. Subgroup analyses were conducted in patients treated with docetaxel who met CLEOPATRA's key eligibility criteria. RESULTS We included 1,065 patients; 313 patients received paclitaxel/nab-paclitaxel and 752 received docetaxel. Patients who received paclitaxel/nab-paclitaxel were older, had a worse Eastern Cooperative Oncology Group Performance Status, and had more recurrent metastatic disease compared with the docetaxel group. After adjustment for potential confounders, similar median rwPFS (inverse probability of treatment weighted average treatment effect for the treated [IPTW-ATT] hazard ratio [HR], 1.09; 95% CI, 0.9 to 1.3; P = .365) and rwOS (IPTW-ATT HR, 1.23; 95% CI, 0.96 to 1.58; P = .101) was observed between treatment groups. In the subgroup of CLEOPATRA-eligible patients, median rwPFS and rwOS were 16.9 months and 57.8 months, respectively. CONCLUSION There was no statistically significant difference in real-world outcomes between patients treated with paclitaxel/nab-paclitaxel and those treated with docetaxel. Selecting patients using key CLEOPATRA eligibility criteria resulted in rwPFS and rwOS similar to those observed in CLEOPATRA, highlighting the importance of ensuring similar patient populations when comparing clinical trial and real-world data.
Centrifugal instabilities in an experimental open cavity flow

We present an experimental parametric study of spanwise centrifugal instabilities in an open cavity flow. We show that the mode selected at threshold depends on the cavity streamwise aspect ratio. For small aspect ratio, a steady mode is enhanced, while travelling waves are observed for large aspect ratio. The bifurcation is found to be supercritical for all configurations. Sidewall effects are shown to generate secondary flows that carry the vortical patterns. Spanwise confinement enhances the family of steady modes relative to the family of oscillatory modes. These results are discussed with respect to predictions from linear stability analyses and other flows developing centrifugal instabilities.
On convergence of transforms based on parabolic scaling

Jouni Sampo ON CONVERGENCE OF TRANSFORMS BASED ON PARABOLIC SCALING Lappeenranta, 2010 72 p. Acta Universitatis Lappeenrantaensis 322 Diss. Lappeenranta University of Technology ISBN 978-952-265-025-2, 978-952-265-026-9 (PDF) ISSN 1456-4491 This thesis studies properties of transforms based on parabolic scaling, like Curvelet-, Contourlet-, Shearletand Hart-Smith-transform. Essentially, two different questions are considered: How these transforms can characterize Holder regularity and how non-linear approximation of a piecewise smooth function converges. In study of Holder regularities, several theorems that relate regularity of a function f : R → R to decay properties of its transform are presented. Of particular interest is the case where a function has lower regularity along some line segment than elsewhere. Theorems that give estimates for direction and location of this line, and regularity of the function are presented. Numerical demonstrations suggest also that similar theorems would hold for more general shape of segment of low regularity. Theorems related to uniform and pointwise Holder regularity are presented as well. Although none of the theorems presented give full characterization of regularity, the sufficient and necessary conditions are very similar. Another theme of the thesis is the study of convergence of non-linear M−term approximation of functions that have discontinuous on some curves and otherwise are smooth. With particular smoothness assumptions, it is well known that squared L approximation error is O(M−2(logM)3) for curvelet, shearlet or contourlet bases. Here it is shown that assuming higher smoothness properties, the log-factor can be removed, even if the function still is discontinuous.
Crystal structure of the dimerized of porcine circovirus type II replication‐related protein Rep′

Porcine circovirus type 2 (PCV2) can cause porcine circovirus‐associated disease (PCVAD), which causes significant economic losses to the global pig industry annually. There are no effective antiviral drugs used to control and treat PCV2, and prevention is mainly obtained through vaccination. PCV2 genome replicates through the rolling circle replication (RCR) mechanism involving Rep and Rep′, so analyzing the holistic structure of Rep and Rep′ will help us better understand the replication process of PCV2. However, there are no reports on the integral structure of Rep′ and Rep, which seriously hinders the research of the viral replication. By using the x‐ray diffraction method, the structure of the Rep′ dimer was resolved by us in this study. Structural analysis revealed that Rep′ is a dimer formed by the interaction of the C‐terminal domain. The two Rep′ form a positively charged groove, which may play an essential role in the viral binding of dsDNA. Together, this study help to understand the replication process of the virus and may also provide new insights into the development of antiviral drugs.
Intention to receive COVID-19 vaccine and its health belief model (HBM)-based predictors: A systematic review and meta-analysis

ABSTRACT The purpose of the research was to pool the intention to receive the COVID-19 vaccine and its health belief model (HBM)-based predictors, which is helpful for decision-makers and program managers around the globe. The relevant database was searched and Joanna Briggs Institute (JBI) appraisal checklist was used to evaluate the studies. I2 test and funnel plot was utilized to check heterogeneity and publication bias, respectively. DerSimonian and Laird random-effects model was used. The overall pooled intention to receive COVID-19 vaccine globally was 67.69%. Higher levels of perceived susceptibility (AOR = 1.85), perceived severity (AOR = 1.45), perceived benefits (AOR = 3.10), and cues to action (AOR = 3.40) positively predicted the intention; whereas high level of perceived barrier negatively predicted it (AOR = 0.53). Health beliefs influenced COVID-19 vaccine intention globally. This implies that individuals need sound health education and publicity about vaccines before vaccination.
Step-by-step Quantitative Assessment of Student-constructed Mathematics Responses

This paper presents the results of accuracy testing of our marking engine that “emulates” human marking processes by checking each step in a scheme of studentconstructed responses to problems on solving equations. The computational methods designed for our marking engine are based on adaptations of textual information retrieval methods and treats mathematical expressions as literal strings. The correctness of expressions in each step is “judged” by comparing the structural similarity between the tokenized string of the expression of the step and that of its model solution using our own similarity measure. A numeric scores in the interval of [0, 1] is awarded. The scores act as quantitative feedbacks that inform students of the degree of correctness of their responses.
Helicity generation and subcritical behaviour in rapidly rotating dynamos

Abstract Numerical dynamo models based on convection-driven flow in a rapidly rotating spherical shell frequently give rise to strong, stable, dipolar magnetic fields. Dipolar dynamos can be subcritical in the sense that strong magnetic fields are sustained at a Rayleigh number lower than that required for a dynamo to grow from a small seed field. In this paper we find subcritical behaviour in dynamos in line with previous studies. We explore the action of Lorentz force in a rotating dynamo which gives rise to a strong preference for dipolar modes over quadrupolar modes, and also makes subcritical behaviour more likely to occur. The coherent structures that arise in rapidly rotating convection are affected by the magnetic field in ways which strongly increase their helicity, particularly if the magnetic field is dipolar. As helicity enhances dynamo action, an existing magnetic field can hold itself up, which leads to subcritical behaviour in the dynamo. We investigate this mechanism by means of the asymptotic small Ekman number theory of rapidly rotating magnetoconvection, and compare our results with fully nonlinear dynamo simulations. There are also other mechanisms which can promote subcritical behaviour. When Reynolds stresses are significant, zonal flows can lower the helicity and disrupt the onset of dynamo action, but an established dipole field can suppress the zonal flow, and hence boost the helicity. Subcriticality means that a slow gradual reduction in Rayleigh number can lead to a catastrophic collapse of the dynamo once a critical Rayleigh number is reached. While there is little evidence that the Earth is currently in a subcritical regime, this may have implications for the long-term evolution of the geodynamo.