Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors controlling erythropoiesis in birds.

1. Erythropoiesis in birds is stimulated by bleeding and environmental hypoxia and is suppressed by induced polycythemia, indicating that the physiologic response is similar to that in mammals. 2. This response is mediated through a humoral factor which stimulates erythropoiesis of birds but not of mammals. Similarly, the erythropoietin of mammals does not stimulate the erythropoiesis of birds. 3. Although both the erythropoiesis stimulating factor of birds and of mammals appear to require an intact protein structure for biological activity, the erythropoietin of birds differs from that of mammals in that it is not destroyed by sialidase and does not lose its activity when reacted with antibody to human urinary erythropoietin.
Analysis of the microstructural evolution of composite of Tungsten with lignin kraft

In materials science and engineering, there is a demand in new materials for radiation shielding in the transport of radiopharmaceuticals used in the diagnosis and therapy of cancer, justifying the interest in developing this work. The obtained lignin kraft and tungsten form the precursors used for metal-organic composite. Tungsten metal has diverse applications in the nuclear sector presents an enormous mechanical strength and an excellent cross section with thermal neutrons. The aim of this study is to analyse the microstructural evolution of metal-organic composite using the kraft lignin and tungsten, using analysis of scanning electron microscopy (SEM), microhardness test and x-ray diffraction (XRD). Microscopic analysis showed the granulometry of the precursors separate and composite morphology, observing the formation of alpha (α) and beta (β) phases and absence of oxidation process for different heat treatment temperatures. The spectra of x-ray diffraction identified the structures of each phase formed and micro hardness measures showed an increase of mechanical resistance with temperature. The results of the microstructural characterization of metal-organic composite, will contribute in the next steps of attenuation measurements of gamma radiation.
Cancer treatments and their side effects are associated with aggravation of insomnia: Results of a longitudinal study

Insomnia affects between 30% to 60% of patients with cancer but to the authors' knowledge little is known regarding factors associated with its development. It has been postulated that adjuvant cancer treatments and their side effects could trigger sleep disturbances in this population but empirical evidence is lacking. The goal of the current study was to assess, separately in patients with breast and prostate cancer, the effect of adjuvant treatments on the evolution of insomnia symptoms and the mediating role of somatic symptoms.
Molecular architecture of the multisubunit homotypic fusion and vacuole protein sorting (HOPS) tethering complex

Membrane fusion within the eukaryotic endomembrane system depends on the initial recognition of Rab GTPase on transport vesicles by multisubunit tethering complexes and subsequent coupling to SNARE-mediated fusion. The conserved vacuolar/lysosomal homotypic fusion and vacuole protein sorting (HOPS) tethering complex combines both activities. Here we present the overall structure of the fusion-active HOPS complex. Our data reveal a flexible ≈30-nm elongated seahorse-like structure, which can adopt contracted and elongated shapes. Surprisingly, both ends of the HOPS complex contain a Rab-binding subunit: Vps41 and Vps39. The large head contains in addition to Vps41 the SNARE-interacting Vps33, whereas Vps39 is found in the bulky tip of its tail. Vps11 and Vps18 connect head and tail. Our data suggest that HOPS bridges Ypt7-positive membranes and chaperones SNAREs at fusion sites.
GPS-Synchronized Data Acquisition: Technology Assessment and Research Issues

GPS-synchronized equipment (PMUs) is in general higher precision equipment as compared to typical SCADA systems. Conceptually, PMU data are time tagged with accuracy of better than 1 microsecond and magnitude accuracy that is better than 0.1%. This potential performance is not achieved in an actual field installation due to errors from instrumentation channels and system imbalances. Presently, PMU data precision from substation installed devices is practically unknown. On the other hand, specific applications of PMU data require specific accuracy of data. Applications vary from simple system monitoring to wide area protection and control to voltage instability prediction. Each application may have different accuracy requirements. For example for simple system monitoring in steady state highly accurate data may not be critical while for transient instability prediction high precision may be critical. For addressing data precision requirements for a variety of applications, it is necessary to quantify the accuracy of the collected PMU data. We discuss data precision requirements for a variety of applications and we propose a methodology for characterizing data errors. In particular, we propose a new approach for improving data accuracy via estimation methods. The proposed methodology quantifies the expected error of the filtered data. Examples are provided that define the instrumentation requirements for specific applications.
Utilization of Metroxylan sagu Pith Waste as Biodegradable Filler for Natural Rubber (NR) Latex Films

Utilization of agricultural waste toward sustainability has increase a value-added product from a natural resources nowadays. Metroxylan sagu pith waste (MSPW) is a residue from starch extraction process. This research aim to investigate the potential of MSPW as a biodegradable fillers to replace sago starch in Natural Rubber (NR) latex films. The MSPW flour is characterized and compared with sago starch. Results shown MSPW has almost similar properties with sago starch with high content of starch (60%) and moisture (80%). Spectra of MSPW and Sago Starch (SS) are very closed to one another due to the similarity of functional groups. SS has granular shape while MSPW has irregular shape under SEM analysis. The addition of MSPW shown slightly lower tensile properties and tear strength as compared to SS but still within the acceptable value. Thus, MSPW has high potiential to replace SS as biodegradable fillers in NR latex films.
Organizational Factors and Change Strategies Associated With Medical Home Transformation

There is limited information about how to transform primary care practices into medical homes. The research team surveyed leaders of the first 132 primary care practices in Minnesota to achieve medical home certification. These surveys measured priority for transformation, the presence of medical home practice systems, and the presence of various organizational factors and change strategies. Survey response rates were 98% for the Change Process Capability Questionnaire survey and 92% for the Physician Practice Connections survey. They showed that 80% to 100% of these certified clinics had 15 of the 18 organizational factors important for improving care processes and that 60% to 90% had successfully used 16 improvement strategies. Higher priority for this change (P = .001) and use of more strategies (P = .05) were predictive of greater change in systems. Clinics contemplating medical home transformation should consider the factors and strategies identified here and should be sure that such a change is indeed a high priority for them.
A novel spark plasma sintering route to process high-strength Ti–4Al–2Fe/TiB nano-composite

ABSTRACT Ti–4Al–2Fe alloy and Ti–4Al–2Fe/TiB nano-composite were processed by a novel spark plasma sintering route. KBF4 was used as an alternative and inexpensive boron precursor to form TiB reinforcement in situ during sintering. Fe was used as an alternative to vanadium to make the (α + β) Ti matrix. The processed Ti–4Al–2Fe alloy exhibited excellent mechanical properties (CS = 1798 MPa). The TiB whiskers were distributed homogeneously and were fine (widths 130 nm and lengths from 100 nm to 3 µm). No residual TiB2 was found in the composite, in contrast with other methods. The TiB homogenised and refined the microstructure, while the hardness (710 HV), compressive strength (2414 MPa) and elastic modulus (140 GPa) all increased significantly when compared to the unreinforced alloy.
Scattering of gravitational waves by the weak gravitational fields of lens objects

We consider the scattering of gravitational waves by the weak gravitational fields of lens objects. We obtain the scattered gravitational waveform by treating the gravitational potential of the lens to first order, i.e. using the Born approxima- tion. We find that the effect of scattering on the waveform is roughly given by the Schwarzschild radius of the lens divided by the wavelength of gravitational wave for a compact lens object. If the lenses are smoothly distributed, the effect of scattering is of the order of the convergence field κ along the line of sight to the source. In the short wavelength limit, the amplitude is magnified by 1 + κ, which is consistent with the result in weak gravitational lensing.
Roles of the ubiquitin proteasome system in the effects of drugs of abuse

Because of its ability to regulate the abundance of selected proteins the ubiquitin proteasome system (UPS) plays an important role in neuronal and synaptic plasticity. As a result various stages of learning and memory depend on UPS activity. Drug addiction, another phenomenon that relies on neuroplasticity, shares molecular substrates with memory processes. However, the necessity of proteasome-dependent protein degradation for the development of addiction has been poorly studied. Here we first review evidences from the literature that drugs of abuse regulate the expression and activity of the UPS system in the brain. We then provide a list of proteins which have been shown to be targeted to the proteasome following drug treatment and could thus be involved in neuronal adaptations underlying behaviors associated with drug use and abuse. Finally we describe the few studies that addressed the need for UPS-dependent protein degradation in animal models of addiction-related behaviors.
Formulation and in-vitro Evaluation of Terbinafine HCL Transdermal Patches

The present study transdermal patches of the Terbinafine Hcl were prepared using polymers like HPMC, SCMC and carbopol 934 with different concentration. These transdermal patches will be characterized for their physicochemical properties like thickness uniformity of patches from 0.211 ± 0.016 mm to 0.232 ± 0.013 mm, weight uniformity of patches between 0.312 ± 0.033 mg and 0.398 ± 0.021 mg, tensile strength of patches vary between 3.21 ± 0.114 to 4.62 ± 0.111 kg/mm, folding endurance of patches between 74.11 ± 4.231 to 97.56 ± 6.231, drug content uniformity, in vitro release studies. Different techniques, FTIR (Fourier Transform infra red) and DSC (differential scanning calorimetry) were used to estimate the incompatibility.
Individual Pulmonary Vein Atresia in Adults: Report of Two Cases

We present two cases of individual pulmonary vein atresia without vestige of an involved pulmonary vein. On CT, we noted the absence or interruption of normal pulmonary venous structures, and the presence of abnormal vascular structures that represented collaterals for the involved lung parenchyma. On angiography, the atretic pulmonary vein was found to drain into the other ipsilateral pulmonary veins through the collaterals.
Identification of Secreted Cysteine Proteases from the Parasitic Nematode Haemonchus contortus Detected by Biotinylated Inhibitors

ABSTRACT Seven cathepsin B-like cysteine proteases (CBLs) were identified from the immunoprotective excretory-secretory products of Haemonchus contortus. Two-dimensional (2-D) zymography and biotinylated inhibitors were employed to localize active CBLs in 2-D protein gels. Mass spectrometry provided the identification of AC-4, HMCP1, HMCP2, and GCP7 as well as three novel CBLs encoded by clustered expressed sequence tags.
Phrase structure and intonational phrases: comments on the chapters by Marcus and Steedman

This paper is a commentary on two papers presented at the Workshop on Cognitive Models of Language, Sperlonga (Italy), May 1988. These two papers are: "Description Theory and Intonation Boundaries" by Mitch Marcus, and "Syntax and Intonation Structure in Combinatory Grammar" by Mark Steedman. Their approaches to the interface between syntax and metrical phonology are compared and certain problems with their approaches have been pointed out. A phrase structure-like approach, which is able to support some flexible phrasing and permit a set of analyses to hold simultaneously has been discussed also. This approach is based on structured objects as syntactic types rather than on curried functional syntactic types as in Steedman's work. Comments University of Pennsylvania Department of Computer and Information Science Technical Report No. MSCIS-89-56. This technical report is available at ScholarlyCommons: http://repository.upenn. edu/cis_reports/849 PHRASE STRUCTURE AND INTONATIONAL PHRASES: COMMENTS ON THE PAPERS BY MARCUS AND STEEDMAN Aravind K. Joshi MS-CIS-89-56 LING LAB 160 Department of Computer and Information Science School of Engineering and Applied Science University of Pennsylvania Philadelphia, PA 19 104
The evidence for β blockers in heart failure

Heart failure is a common, malignant condition for which hospital admissions are rising rapidly.1–3 Despite the evidence that angiotensin converting enzyme inhibitors improve the morbidity and mortality of heart failure secondary to left ventricular systolic dysfunction, the prognosis of heart failure in the community has improved little over the past 30 years.4 This may reflect a reluctance to prescribe angiotensin converting enzyme inhibitors.4 Now, however, evidence has accumulated to show that β blockers, when used in addition to angiotensin converting enzyme inhibitors, also reduce mortality in heart failure. Will this be another lost opportunity? The CIBIS-II study,5 comparing bisoprolol with placebo, recently reported a highly significant reduction in all cause mortality. When these data and those from other smaller trials6–8 identified from searches of Medline and Embase and recent meetings9 are added to those reported in previous meta-analyses10 there are now 25 trials that have randomised patients with heart failure to β blocker or control, comprising 6511 patients and 810 deaths. Overall β blockers reduced the odds of death by 36% (95% confidence interval 25% to 45%) (fig 1). There is no evidence of heterogeneity between …
Chlamydia co‐opts the rod shape‐determining proteins MreB and Pbp2 for cell division

Chlamydiae are obligate intracellular bacterial pathogens that have extensively reduced their genome in adapting to the intracellular environment. The chlamydial genome contains only three annotated cell division genes and lacks ftsZ. How this obligate intracellular pathogen divides is uncharacterized. Chlamydiae contain two high‐molecular‐weight (HMW) penicillin binding proteins (Pbp) implicated in peptidoglycan synthesis, Pbp2 and Pbp3/FtsI. We show here, using HMW Pbp‐specific penicillin derivatives, that both Pbp2 and Pbp3 are essential for chlamydial cell division. Ultrastructural analyses of antibiotic‐treated cultures revealed distinct phenotypes: Pbp2 inhibition induced internal cell bodies within a single outer membrane whereas Pbp3 inhibition induced elongated phenotypes with little internal division. Each HMW Pbp interacts with the Chlamydia cell division protein FtsK. Chlamydiae are coccoid yet contain MreB, a rod shape‐determining protein linked to Pbp2 in bacilli. Using MreB‐specific antibiotics, we show that MreB is essential for chlamydial growth and division. Importantly, co‐treatment with MreB‐specific and Pbp‐specific antibiotics resulted in the MreB‐inhibited phenotype, placing MreB upstream of Pbp function in chlamydial cell division. Finally, we showed that MreB also interacts with FtsK. We propose that, in Chlamydia, MreB acts as a central co‐ordinator at the division site to substitute for the lack of FtsZ in this bacterium.
Robonaut task learning through teleoperation

This paper addresses the problem of automatic skill acquisition by a robot. It reports that six trials of a reach-grasp-release-retract skill are sufficient for learning a canonical description of the task under the following circumstances: The robot is Robonaut, NASA's space-capable, dexterous humanoid. Robonaut was teleoperated by a person using full immersion Virtual Reality technology that transforms the operator's arm and hand motions into those of the robot. The operator's sole source of real-time feedback was visual. During the six trials all of the Robot's sensory inputs and motor control parameters were recorded as time-series. Later the time-series from each trial was partitioned into the same number of episodes as a function of changes in the motor parameter sequence. The episodes were time normalized and averaged across trials The resultant motor parameter sequence and sensor signals were used to control the robot without the teleoperator. The robot was able to perform the task autonomously with robot starting positions and object locations both similar to, and different from the original trials.
Filters on the pathway to mental health care, II. Sociodemographic factors

Synopsis This study uses the prospectively gathered data of the Epidemiologic Catchment Area Program, a multi-site interview survey of mental disturbances among adult household residents in the United States, to compare health services use by individuals with different sociodemographic characteristics, accounting for the first-time occurrence of psychiatric disorder, over the course of a 1-year follow-up interval. Case ascertainment was by means of a standardized interview method, the Diagnostic Interview Schedule. In the present investigation, 13400 continuing participants in the household sample who reported no contact with mental health services in the 6 months prior to the initial interview were studied with regard to health services use and sociodemographic characteristics. Separately, and before the mental health assessments were made, respondents were asked about their use of health and mental health services. African-Americans were significantly less likely than whites to have consulted with a specialist in mental health (estimated relative odds, 0·22, 95% confidence interval 0·10 to 0·52), even accounting for coincident psychiatric disorder, gender, and other covariates known to be associated with differential use of health care services. Hispanics and other minorities were also less likely to have consulted a specialist in mental health (estimated relative odds, 0·37 and 0·26, respectively). This large community study extends previous work on mental health services and ethnicity.
Sparse Signal Recovery Using gOMP Assisted mOLS

Because of fast convergence in finite number of steps and low computational complexity, signal recovery from compressed measurements using greedy algorithms have generated a large amount of interest in recent years. Among these greedy algorithms OMP is well studied and recently its generalization, gOMP, have also drawn attention. On the other hand OLS and its generalization mOLS have been studied in recent years because of their potential advantages in signal recovery guarantee compared to OMP or gOMP. But OLS and mOLS have the shortcomings of high computational complexity. In this paper we propose a new algorithm which uses gOMP to preselect a N length set out of which mOLS selects its L best coefficients. We have shown that our new algorithm, named gOMPamOLS, is guaranteed to reconstruct a K sparse signals perfectly from compressed measurements if the restricted isometry constant satisfies $\delta_{LK+N}<\frac{\sqrt{L}}{\sqrt{L}+\sqrt{K+L}}$ . Moreover experimental results indicate that gOMPamOLS is robust under sensing matrix with correlated dictionary in terms of signal reconstruction and is much faster than OLS.
A genetic test for expression of a functional herpes simplex virus DNA-binding protein from a transfected plasmid

The major DNA-binding protein, ICP8, encoded by herpes simplex virus is localized to the infected cell nucleus where it plays a role in viral DNA replication and control of viral gene expression. To identify the parts of the ICP8 protein that are important for its localization and functions, we have developed a system to test the ability of recombinant plasmids to express functional ICP8. A recombinant plasmid containing the wild-type ICP8 gene was transfected into cells. The cells were later infected with a temperature-sensitive ICP8 mutant virus at the nonpermissive temperature. Sufficient wild-type ICP8 was expressed from the transfected plasmid to complement the replication of the mutant virus. This provides a genetic system to test the properties of ICP8 expressed from mutagenized plasmids without the establishment of a stable cell line or the reintroduction of the ICP8 gene into the herpes simplex virus genome.
Personnel and unit factors impacting outcome after cardiac arrest in a dedicated pediatric cardiac intensive care unit*

Objective: To assess the impact of personnel and unit factors on outcome from cardiac arrest in a dedicated pediatric cardiac intensive care unit. Design: Retrospective medical record review. Setting: Dedicated cardiac intensive care unit at a quaternary academic children’s hospital. Patients: Children and young adults who had cardiac arrest while cared for in the pediatric cardiac intensive care unit from January 1, 2006, to December 31, 2008. Interventions: None. Measurements and Main Results: One hundred two index cardiac arrests over a 3-yr period in our pediatric cardiac intensive care unit were reviewed. We defined successful resuscitation as either return of spontaneous circulation or successful cannulation to extracorporeal membrane oxygenation. Differences in resuscitation rates were assessed across categorical systems variables using logistic regression. The rate of successful resuscitation was 84% (return of spontaneous circulation 74%, extracorporeal membrane oxygenation 10%). Survival to hospital discharge was 48% for patients who had a cardiac arrest. 11% of arrests during the week and 31% during weekends (odds ratio 3.8; 95% confidence interval 1.2–11.5) were not successfully resuscitated. Unsuccessful resuscitation was significantly more likely when the primary nurse had <1 yr of experience in the pediatric cardiac intensive care unit (50% <1 yr vs. 13% >1 yr; odds ratio 6.8; confidence interval 1.5–31.0). Cardiac arrest on a weekend day and <1-yr pediatric cardiac intensive care unit nursing experience were also associated with unsuccessful resuscitation in a multivariable model. Resuscitation outcomes were similar when senior intensive care unit attending physicians were on-call at the time of arrest compared with other intensive care unit staff (17% unsuccessful vs. 15%; odds ratio 1.2; confidence interval 0.4–3.7). Arrests where the attending physician was present at the onset resulted in unsuccessful resuscitation 18% of the time vs. 14% for events where the attending was not present (odds ratio 1.3; confidence interval 0.5–3.9). Conclusions: Our data suggest that personnel and unit factors may impact outcome after cardiac arrest in a pediatric cardiac intensive care unit. Weekend arrests and less experience of the primary nurse were risk factors for unsuccessful resuscitation. Neither presence at arrest onset nor experience of the attending cardiac intensivist was associated with outcome.