Miracle-dz/UniFAR-FTUs huggingface dataset:
Personal Resources and Homelessness in Early Life: Predictors of Depression in Consumers of Homeless MultiService Centers

This study explored the relationship between personal resources and previous adverse life events such as homelessness and depression. Participants were recruited from two church sponsored multisite social service centers in Anne Arundel County, Maryland. The interview included demographics and several standardized scales to assess history of homelessness, medical history, personal resources, and depressive symptoms. A hierarchical multiple regression analysis revealed that participants with higher levels of depressive symptoms were older, had a history of homelessness, had more health problems, had a history of mental illness, and had lower self-esteem, mastery, and mattering. A subanalysis indicated that individuals who had experienced homelessness at or before age 21 had higher levels of depressive symptoms than those who were first homeless as an adult. Previous history of homelessness, especially before age 21, and lack of personal resources may place individuals at risk for psychological distress, including higher levels of depressive symptoms.
Natural Killer Cell Mediated Missing-Self Recognition Can Protect Mice from Primary Chronic Myeloid Leukemia In Vivo

Background Natural Killer (NK) cells are thought to protect from residual leukemic cells in patients receiving stem cell transplantation. However, multiple retrospective analyses of patient data have yielded conflicting conclusions regarding a putative role of NK cells and the essential NK cell recognition events mediating a protective effect against leukemia. Further, a NK cell mediated protective effect against primary leukemia in vivo has not been shown directly. Methodology/Principal Findings Here we addressed whether NK cells have the potential to control chronic myeloid leukemia (CML) arising based on the transplantation of BCR-ABL1 oncogene expressing primary bone marrow precursor cells into lethally irradiated recipient mice. These analyses identified missing-self recognition as the only NK cell-mediated recognition strategy, which is able to significantly protect from the development of CML disease in vivo. Conclusion Our data provide a proof of principle that NK cells can control primary leukemic cells in vivo. Since the presence of NK cells reduced the abundance of leukemia propagating cancer stem cells, the data raise the possibility that NK cell recognition has the potential to cure CML, which may be difficult using small molecule BCR-ABL1 inhibitors. Finally, our findings validate approaches to treat leukemia using antibody-based blockade of self-specific inhibitory MHC class I receptors.
Context-Aware Adaptive Framework for e-Health Monitoring

For improving e-health services, we propose a context-aware framework to monitor the activities of daily living of dependent persons. We define a strategy for generating long-term realistic scenarios and a framework containing an adaptive monitoring algorithm based on three approaches for optimizing resource usage. The used approaches provide a deep knowledge about the person's context by considering: the person's profile, the activities and the relationships between activities. We evaluate the performances of our framework and show its adaptability and significant reduction in network, energy and processing usage over a traditional monitoring implementation.
Validation of the Female Sexual Function Index (FSFI) in Women with Female Orgasmic Disorder and in Women with Hypoactive Sexual Desire Disorder

Department of Psychology, University of Texas at Austin, Austin, Texas, USA The Female Sexual Functioning Index (FSFI; Rosen et al., 2000) is a self-report measure of sexual functioning that has been validated on a clinically diagnosed sample of women with female sexual arousal disorder. The present investigation extended the validation of the FSFI to include women with a primary clinical diagnosis of female orgasmic disorder (FOD; n = 71) or hypoactive sexual desire disorder (HSDD; n = 44). Internal consistency and divergent validity of the FSFI were within the acceptable range for these populations of women. Significant differences between women with FOD and controls and between women with HSDD and controls were noted for each of the FSFI domain and total scores.
Provable Ownership of Encrypted Files in De-duplication Cloud Storage

The rapid adoption of cloud storage services has created an issue that many duplicated copies of files are stored in the remote storage servers, which not only wastes the communication bandwidth for duplicated file uploading, but also increases the cost of security data management. To solve this problem, client-side deduplication was introduced to avoid the client from uploading files already existed in the remote servers. However, the existing scheme was recently found to be vulnerable to security attacks in that by learning a small piece of information related to the file, such as the hash value of the file, the attacker may be able to get full access of the entire file; and the confidentiality of the date may be vulnerable to “honest-but-curious” attacks. In this paper, to solve the problems mentioned above, we propose a cryptographically secure and efficient scheme to support cross-user client side deduplication over encrypted file. Our scheme utilizes the technique of spot checking in which the client only need to access small portions of the original file, dynamic coefficients, randomly chosen indices of the original files and a subtle approach to distribute the file encrypting key among clients to satisfy security requirements. Our extensive security analysis shows that the proposed scheme can generate provable ownership of the encrypted file (POEF) with the presence of the curious server, and maintain a high detection probability of the client misbehavior. Both performance analysis and simulation results demonstrate that our proposed scheme is much more efficient than the existing schemes, especially in reducing the burden of the client.
Road-maps and revelations: on the somatic ethics of genetic susceptibility

Understanding genomic susceptibility risk has been represented as key to a new era of personalized medicine, in which “empowered” individuals shape their lives according to a “somatic ethics” of genetic risk management. Based on a comprehensive analysis of websites and other documents produced by key companies within the personal genomics industry, I argue that the rhetoric of empowerment these companies employ constructs an “ideal subject” of personal genomics while also expressing tensions implicit within the idea of a somatic ethics based on genetic susceptibility. Using Kaushik Sunder Rajan's concept of “genomic fetishism,” I show how these tensions arise from the relationship the rhetoric of personal genomics constructs between risk and uncertainty, and relate them to broader tensions within “risk thinking” as a mode of governmentality that extends beyond genomics.
Multidrug Resistance Mediated by MRP1 Gene Overexpression in Breast Cancer Patients

Multidrug resistance (MDR) is a serious handicap towards the effective treatment of breast cancer patients. One of the most prevalent MDR mechanisms is through the overexpression of genes coding the proteins called Multidrug Resistance-associated Proteins (MRPs). The aim of this study was to investigate the expression of MRP1 in tumor tissues from breast cancer patients. In this study, a semi-quantitative RT-PCR approach was utilized. Our results suggest that MRP1 overexpression can mediate MDR in patients. Pre-evaluation of the level of such MDR mediators before chemotherapy can increase the efficacy of the treatment.
Hitchhiking Effect of a Beneficial Mutation Spreading in a Subdivided Population

A central problem in population genetics is to detect and analyze positive natural selection by which beneficial mutations are driven to fixation. The hitchhiking effect of a rapidly spreading beneficial mutation, which results in local removal of standing genetic variation, allows such an analysis using DNA sequence polymorphism. However, the current mathematical theory that predicts the pattern of genetic hitchhiking relies on the assumption that a beneficial mutation increases to a high frequency in a single random-mating population, which is certainly violated in reality. Individuals in natural populations are distributed over a geographic space. The spread of a beneficial allele can be delayed by limited migration of individuals over the space and its hitchhiking effect can also be affected. To study this effect of geographic structure on genetic hitchhiking, we analyze a simple model of directional selection in a subdivided population. In contrast to previous studies on hitchhiking in subdivided populations, we mainly investigate the range of sufficiently high migration rates that would homogenize genetic variation at neutral loci. We provide a heuristic mathematical analysis that describes how the genealogical structure at a neutral locus linked to the locus under selection is expected to change in a population divided into two demes. Our results indicate that the overall strength of genetic hitchhiking—the degree to which expected heterozygosity decreases—is diminished by population subdivision, mainly because opportunity for the breakdown of hitchhiking by recombination increases as the spread of the beneficial mutation across demes is delayed when migration rate is much smaller than the strength of selection. Furthermore, the amount of genetic variation after a selective sweep is expected to be unequal over demes: a greater reduction in expected heterozygosity occurs in the subpopulation from which the beneficial mutation originates than in its neighboring subpopulations. This raises a possibility of detecting a “hidden” geographic structure of population by carefully analyzing the pattern of a selective sweep.
AN OVERVIEW OF COMPOSITE LIKELIHOOD METHODS

A survey of recent developments in the theory and application of com- posite likelihood is provided, building on the review paper of Varin(2008). A range of application areas, including geostatistics, spatial extremes, and space-time mod- els, as well as clustered and longitudinal data and time series are considered. The important area of applications to statistical genetics is omitted, in light ofLarribe and Fearnhead(2011). Emphasis is given to the development of the theory, and the current state of knowledge on e! ciency and robustness of composite likelihood inference.
THE FIRST FIVE YEARS: A PROGRESS REPORT ON THE COMMONWEALTH COUNCIL FOR EDUCATIONAL ADMINISTRATION

In August 1975, the Commonwealth Council for Educational Administration will be five years old. In furtherance of its seven‐fold objectives CCEA has formulated and embarked on a publications programme, organized conferences and seminar/ workshops at which the principles and practice of educational administration were discussed, encouraged the foundation of affiliated groups of educational administrators in Commonwealth countries, carried out its first survey of aspects of educational administration within the Commonwealth, and arranged visits of specialists among countries. Recently its constitution was approved thus enabling CCEA to extent its activities further within the guidelines developed during its first quinquennium.
Raça, classe e cultura no contexto das políticas de ação afirmativa: um esforço teórico-crítico a respeito da raça

O presente artigo se propoe a discutir tres questoes caras ao debate sociologico em torno das chamadas “questoes raciais” e, de algum modo, retomadas no contexto da implementacao das politicas de cotas no Brasil, a saber: a relacao entre raca e classe; a interface da raca com a cultura/etnia; e o status da raca como categoria social e conceito analitico. Esta discussao sera feita a luz do debate que antecedeu e se intensificou por ocasiao da introducao das primeiras politicas de cotas em universidades publicas. Primeiramente, faz-se uma incursao em torno do embate teorico relativo a interdependencia das categorias “raca” e “classe” de modo a exemplificar a maneira atraves da qual elas se relacionam no contexto da experiencia de acoes afirmativas para negros. Em seguida, desenvolve-se uma reflexao critica a respeito da interface teorica entre raca e cultura a luz das disputas relativas aos significados da identidade negra nesse contexto. Finalmente, analisam-se as discussoes em torno dos significados raciais no contexto da implementacao de politicas publicas afirmativas, com o objetivo de propor uma analise reflexiva a respeito da raca como conceito analitico.
The hpx Genetic System for Hypoxanthine Assimilation as a Nitrogen Source in Klebsiella pneumoniae: Gene Organization and Transcriptional Regulation

ABSTRACT Growth experiments showed that adenine and hypoxanthine can be used as nitrogen sources by several strains of K. pneumoniae under aerobic conditions. The assimilation of all nitrogens from these purines indicates that the catabolic pathway is complete and proceeds past allantoin. Here we identify the genetic system responsible for the oxidation of hypoxanthine to allantoin in K. pneumoniae. The hpx cluster consists of seven genes, for which an organization in four transcriptional units, hpxDE, hpxR, hpxO, and hpxPQT, is proposed. The proteins involved in the oxidation of hypoxanthine (HpxDE) or uric acid (HpxO) did not display any similarity to other reported enzymes known to catalyze these reactions but instead are similar to oxygenases acting on aromatic compounds. Expression of the hpx system is activated by nitrogen limitation and by the presence of specific substrates, with hpxDE and hpxPQT controlled by both signals. Nitrogen control of hpxPQT transcription, which depends on σ54, is mediated by the Ntr system. In contrast, neither NtrC nor the nitrogen assimilation control protein is involved in the nitrogen control of hpxDE, which is dependent on σ70 for transcription. Activation of these operons by the specific substrates is also mediated by different effectors and regulatory proteins. Induction of hpxPQT requires uric acid formation, whereas expression of hpxDE is induced by the presence of hypoxanthine through the regulatory protein HpxR. This LysR-type regulator binds to a TCTGC-N4-GCAAA site in the intergenic hpxD-hpxR region. When bound to this site for hpxDE activation, HpxR negatively controls its own transcription.
Design of a wide input range DC/DC converter based on SEPIC topology for fuel cell power conversion

This thesis presents the design and implementation of a wide input range DC/DC converter based on SEPIC topology for fuel cell power system. The power converters can not only transfer the power from fuel cells to the load, but also improve stability and safety of the system. In the proposed system, a SEPIC DC/DC converter is designed to boost the voltage of dc bus to 200V. A single-phase full-bridge inverter is added to convert dc bus into a 110V, 60Hz single-phase ac source by using the technique unipolar-switching. Finally, another SEPIC converter and a buck converter are introduced to discharge or charge batteries for achieving power sharing and load regulations. A rated power of 800 W and peak power of 1 kW of a hybrid power generation system including two SEPIC converters, a buck converter and a full-bridge single-phase single-pole inverter are constructed and tested to verify the system performance.
Symbols of Change: Urban Transition in a Zambian Community

Based on a four-year longitudinal study of urban adaptation in Lusaka, Zambia, this book offers both a theoretical analysis and a case study of African urbanization as a social process. The author's unique approach to this topic lies in her exploration of city-life adjustment through the subjective perception of the new urbanites themselves. The book contains the original interview material and numerous photos of the extensive fieldwork.
Differences in aromatic-DNA adduct levels between alveolar macrophages and subpopulations of white blood cells from smokers.

The 32P-post-labelling assay for DNA adduct quantification gives the opportunity to examine endogenous exposure to DNA reactive compounds. Most human biomonitoring studies applied white blood cells (WBC) or cells obtained by broncho-alveolar lavages (BAL) as source of DNA, but still it is not clear what cell type represents the most reliable indicator for exposure to cigarette smoke-associated genotoxins. At first, we examined DNA adduct levels by means of nuclease P1 (NP1) enriched 32P-post-labelling in separated WBC subpopulations after in vitro incubations for 18 h with 10 microM benzo[a]pyrene (B[a]P). DNA adduct levels were highest in monocytes (10.7 +/- 2.9 adducts/10(8) nucleotides, n = 8), followed by lymphocytes (5.9 +/- 1.7, n = 8), and granulocytes (0.5 +/- 0.2, n = 8). Secondly, aromatic-DNA adduct levels were determined in BAL cells and WBC-subsets from (non-)smoking volunteers. In smoking individuals, adduct levels were in the ranking order: BAL cells (3.7 +/- 1.0, n = 5) > monocytes (2.0 +/- 0.5, n = 8) > or = lymphocytes (1.6 +/- 0.4, n = 8) > granulocytes (0.8 +/- 0.2, n = 8) by NP1-enrichment and monocytes (9.0 +/- 3.2, n = 5) > or = lymphocytes (8.0 +/- 2.1, n = 6) > granulocytes (2.1 +/- 0.3, n = 7) by butanol-enriched 32P-post-labelling. Aromatic-DNA adduct levels were significantly higher in WBC-subsets of smokers as compared with non-smokers, except for DNA adducts in granulocytes using butanol enrichment. Thirdly, dose-response relationships were investigated in mononuclear white blood cells (MNC, i.e. monocytes plus lymphocytes) and BAL-cells of a larger group of smoking individuals (n = 78). Adduct levels in MNC were related to daily exposure to cigarette-tar (r = 0.31, P < 0.01). Adduct levels in BAL cells seemed to be correlated with pack-years, but after correction for age this relationship was lost. Butanol extraction resulted in 5-6-fold higher DNA adduct levels in MNC, whereas butanol extraction of BAL-DNA of the same individuals yielded only 2-fold higher adduct levels. The two enrichment procedures of 32P-post-labelling were correlated in BAL cells (r = 0.86, P < 0.001, n = 12). We conclude that particularly MNC are good surrogates for the detection of smoking-related DNA adducts.
Gratitude Enhances Change in Athletes’ Self-Esteem: The Moderating Role of Trust in Coach

Self-esteem is a positive evaluation of oneself that can facilitate optimal functioning. However, little research has focused on its antecedents in sport. Accordingly, we adopted an interactionism perspective and proposed that gratitude, a dispositional factor, will enhance an athlete's self-esteem and affective trust in coach, a situational factor, will strengthen such a positive effect. Athletes completed measures of gratitude, affective trust in coach, and self-esteem at Time 1 and self-esteem at Time 2 after 6 months. Results showed that athletes with higher levels of gratitude increased their self-esteem over time when they had higher affective trust in their coaches.
Institutional and organizational factors associated to academic patenting in a Mexican university: Teams' trajectories, networks and performance

This paper explores the main characteristics of the most productive academic teams, when productivity is defined in terms of the number of granted patents. The Metropolitan Autonomous University is the fourth patent producer in the country, among academic institutions. Institutional arrangements and university policies configure a complex set of incentives and restrictions that affect patenting. Institutional arrangements and policies are used to explain groups' trajectories, composition and performance. The hypothesis assumes that better performance is associated with group characteristics such as: Density, reciprocity, centrality, internal and external links, students' participation, publications, industry links, and financial support. University patent information and professors' curriculum vitae were used to characterize and to identify groups through network analysis. Group leaders and team members were interviewed in order to explore their trajectories and challenges. Also the interviewees discussed the role of institutional and organizational factors related to group performance. Results show that industry links and student participation at the patenting group are important characteristics related to performance. Also, it has been found that leader orientation to risk could explain the network dynamic and industry links. The more resources generated by the group, the greater the independence from organizational formal structures.
The Plastidic Pentose Phosphate Translocator Represents a Link between the Cytosolic and the Plastidic Pentose Phosphate Pathways in Plants1

Plastids are the site of the reductive and the oxidative pentose phosphate pathways, which both generate pentose phosphates as intermediates. A plastidic transporter from Arabidopsis has been identified that is able to transport, in exchange with inorganic phosphate or triose phosphates, xylulose 5-phosphate (Xul-5-P) and, to a lesser extent, also ribulose 5-phosphate, but does not accept ribose 5-phosphate or hexose phosphates as substrates. Under physiological conditions, Xul-5-P would be the preferred substrate. Therefore, the translocator was named Xul-5-P/phosphate translocator (XPT). The XPT shares only approximately 35% to 40% sequence identity with members of both the triose phosphate translocator and the phosphoenolpyruvate/phosphate translocator classes, but a higher identity of approximately 50% to glucose 6-phosphate/phosphate translocators. Therefore, it represents a fourth group of plastidic phosphate translocators. Database analysis revealed that plant cells contain, in addition to enzymes of the oxidative branch of the oxidative pentose phosphate pathway, ribose 5-phosphate isomerase and ribulose 5-phosphate epimerase in both the cytosol and the plastids, whereas the transketolase and transaldolase converting the produced pentose phosphates to triose phosphates and hexose phosphates are probably solely confined to plastids. It is assumed that the XPT function is to provide the plastidic pentose phosphate pathways with cytosolic carbon skeletons in the form of Xul-5-P, especially under conditions of a high demand for intermediates of the cycles.
ZooZBeat: a Gesture-based Mobile Music Studio

ZooZBeat is a gesture-based mobile music studio. It is designed to provide users with expressive and creative access to music making on the go. ZooZBeat users shake the phone or tap the screen to enter notes. The result is quantized, mapped onto a musical scale, and looped. Users can then use tilt and shake movements to manipulate and share their creation in a group. Emphasis is placed on finding intuitive metaphors for mobile music creation and maintaining a balance between control and ease-of-use that allows non-musicians to begin creating music with the application immediately.