Miracle-dz/UniFAR-FTUs huggingface dataset:
Longitudinal diffusion tensor imaging and neuropsychological correlates in traumatic brain injury patients

Traumatic brain injury (TBI) often involves focal cortical injury and white matter (WM) damage that can be measured shortly after injury. Additionally, slowly evolving WM change can be observed but there is a paucity of research on the duration and spatial pattern of long-term changes several years post-injury. The current study utilized diffusion tensor imaging to identify regional WM changes in 12 TBI patients and nine healthy controls at three time points over a four year period. Neuropsychological testing was also administered to each participant at each time point. Results indicate that TBI patients exhibit longitudinal changes to WM indexed by reductions in fractional anisotropy (FA) in the corpus callosum, as well as FA increases in bilateral regions of the superior longitudinal fasciculus (SLF) and portions of the optic radiation (OR). FA changes appear to be driven by changes in radial (not axial) diffusivity, suggesting that observed longitudinal FA changes may be related to changes in myelin rather than to axons. Neuropsychological correlations indicate that regional FA values in the corpus callosum and sagittal stratum (SS) correlate with performance on finger tapping and visuomotor speed tasks (respectively) in TBI patients, and that longitudinal increases in FA in the SS, SLF, and OR correlate with improved performance on the visuomotor speed (SS) task as well as a derived measure of cognitive control (SLF, OR). The results of this study showing progressive WM deterioration for several years post-injury contribute to a growing literature supporting the hypothesis that TBI should be viewed not as an isolated incident but as a prolonged disease state. The observations of long-term neurological and functional improvement provide evidence that some ameliorative change may be occurring concurrently with progressive degeneration.
An Interface based on Switched-Capacitor Sample/Hold circuit of Differential Capacitance Transducers

For high-accuracy and high-speed signal processing of differential capacitance transducers, an interface circuitry based on a switched-capacitor sample/hold circuit using unity-gain buffer (UGB) is developed. The interface produces the output voltage which is proportional to the ratio of difference-to-sum of two capacitors of a differential transducer using only single reference voltage, V r . Hspice simulations are described to predict performances of the interface when implemented by 0.35㎛ n-well CMOS process. Experimental results using discrete components are also given to confirm the principles of operation.
Reducing Pediatric HIV Infection: Estimating Mother-to-Child Transmission Rates in a Program Setting in Zambia

Background:Vertical transmission of HIV remains the main source of pediatric HIV infection in Africa with transmission rates as high as 25%-45% without intervention. Even though effective interventions to reduce vertical transmission of HIV are now available and remarkable progress has been made in scaling up prevention of mother-to-child transmission (PMTCT) services, the effectiveness of PMTCT interventions is unknown in Zambia. In this study, we estimate HIV vertical transmission rates at different age bands among perinatally exposed children. Methods:The study analyzed program data of DNA polymerase chain reaction results and selected client information on dried blood spot samples from perinatally exposed children aged 0-12 months sent to the polymerase chain reaction laboratory from 5 provinces between September 2007 and January 2009. Results:Samples of 8237 babies between 0 and 12 months were analyzed, with 84% of the mothers having ever breastfed their children. The observed transmission rate was 6.5% (5.1%, 7.8%) among infants aged 0-6 weeks when both mother and infant received interventions compared with 20.9% (12.3%, 29.5%) where no intervention was given to either mother or baby. Observed HIV transmission with single-dose nevirapine (sdNVP) was 8.5% (5.9%, 11.0%) among infants aged 0-6 weeks, whereas zidovudine with sdNVP (zidovudine + NVP) and highly active antiretroviral therapy were associated with observed transmission rates of 6.8% (4.5%, 9.1%) and 5.0% (3.0%, 7.0%), respectively; whereas these estimates were not significantly different from one another, they were all significantly lower than no intervention for which the estimated rate was 20.9%. Regardless of the intervention, the observed transmission rates were higher among infants aged 6-12 months. Conclusions:PMTCT interventions, including sdNVP, are working in program settings. However, postnatal transmission especially after 6 months through suboptimal feeding practises remains an important challenge to further reduce pediatric HIV.
Experience alters the spatial tuning of auditory units in the optic tectum during a sensitive period in the barn owl

The auditory spatial tuning of bimodal (auditory-visual) units in the optic tectum of the barn owl was altered by raising animals with one ear occluded. Changes in spatial tuning were assessed by comparing the location of a unit's auditory best area with that of its visual receptive field. As shown previously, auditory best areas are aligned with visual receptive fields in the tecta of normal birds (Knudsen, E. I. (1982) J. Neurosci. 2: 1177–1194). It was demonstrated in this study that, when birds were raised with one ear occluded, best areas and visual receptive fields were aligned only as long as the earplug was in place. When the earplug was removed, best areas and visual receptive fields became misaligned, indicating that a change in auditory spatial tuning had taken place during the period of occlusion. However, in a bird that received an earplug as an adult, no such alterations in auditory spatial tuning were observed; even after 1 year of monaural occlusion, auditory best areas and visual receptive fields were misaligned so long as the earplug was in place, and were aligned when the earplug was removed. These results suggest that exposure to abnormal localization cues modifies the auditory spatial tuning of tectal units only during a restricted, sensitive period early in development. After the earplug was removed from a juvenile bird that had been raised with an occluded ear, the initial misalignment between auditory best areas and visual receptive fields decreased gradually over a period of weeks. In contrast, when earplugs were removed from two adult birds that had been raised with monaural occlusions, auditory- visual misalignments persisted for as long as measurements were made, which was up to 1 year after earplug removal. These data indicate that auditory cues become permanently associated with locations in visual space during a critical period which draws to a close at about the age when the animal reaches adulthood. Horseradish peroxidase was injected into two optic tecta (in a single animal) that contained units with permanently altered auditory spatial tuning. The positions of retrogradely labeled cells in the external nucleus of the inferior colliculus (ICX) were the same as those observed in control birds (Knudsen, E. I., and P. F. Knudsen (1983) J. Comp. Neurol. 218: 187–196). Thus, the changes in spatial tuning were not due to a shift in the topographic projection from the ICX to the optic tectum. (ABSTRACT TRUNCATED AT 400 WORDS)
Dynamic correlation between induction of the expression of heme oxygenase-1 and hepatitis B viral replication.

Heme oxygenase‑1 (HO‑1) possesses significant potential as a drug target for hepatitis B, which may be transferable to patient therapy. The aim of the present study was to clarify the dynamic correlation between the hepatitis B virus (HBV) and HO‑1. The levels of HBV replication and expression of HO‑1 were investigated in HepG2.2. 15 hepatoma cells following exposure to 5‑50 µM hemin for 1‑6 days. The mRNA expression levels of HO‑1 were then detected using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). HBV replication levels were determined by enzyme‑immunoassay and a PCR‑fluorescence quantitation assay. The results of the present study demonstrated that the mRNA expression levels of HO‑1 increased in a dose‑dependent manner in the HepG2.2. 15 cells, following exposure to 5‑50 µM hemin. The mRNA expression levels of HO‑1 reached a peak following exposure of the cells to hemin for three days, subsequently the expression of HO‑1 decreased. Following exposure to hemin at an optimal concentration of 50 µM for 1‑6 days, the levels of the hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) in the cells were significantly reduced. This marked reduction in the expression of HBsAg and HBeAg reached its peak on the first day, following which the inhibition weakened as the duration of exposure increased. In addition, the inhibition of HBV DNA replication increased with the a longer duration of exposure. Furthermore, HBV DNA levels were significantly decreased following exposure to hemin for 3‑6 days. In conclusion, the present study demonstrated that induced expression of HO‑1 interfered with HBV replication in a dose and time‑dependent manner, implying that a reduction of the HBV viral load may contribute to upregulation in the expression of HO‑1.
Contributing factors of obesity among stressed adolescents

Background: Many adolescents suffer from common mental disorders such as stress, which affects health through the psychosocial process, eating behavior, food choices and physical activity. During adolescence, dietary patterns are formed and can affect the occurrence of diseases in later life. This is a review of the results in the pertinent literature, from 1989 until November 2013, concerning stress and the contributing factors that lead to obesity among adolescents. The aim of this review is to identify obesity among stressed adolescents as well as the contributing factors. Methods: A descriptive design was used for both quantitative and qualitative studies while, in addition, psychological theories were used for the qualitative studies. The articles were screened to ensure their quality and included in this review accordingly. Ten articles were included in the review comprising cross-sectional, cohort, review and meta-analysis. Interviews and questionnaires were used for data collection. Results: The literature provided obvious information focusing on emotional stress and obesity for both boys and girls. This review revealed that stress results in overweight and obesity among adolescents through changes in lifestyle including decreased physical activity and increased food intake. Gender and economic status are the main components that affect obesity in stressed adolescents. Conclusion: Obesity is a consequence of stress among adolescents and is exacerbated by the wrong eating attitude. Developing proper food choices among adolescents can help prevent obesity and other complications in adulthood.
Reproductive ecology and scientific inference of steepness: a fundamental metric of population dynamics and strategic fisheries management

The relationship between the biomass of reproductively mature individuals (spawning stock) and the resulting offspring added to the population (recruitment), the stock‐recruitment relationship, is a fundamental and challenging problem in all of population biology. The steepness of this relationship is commonly defined as the fraction of recruitment from an unfished population obtained when the spawning stock biomass is 20% of its unfished level. Since its introduction about 20 years ago, steepness has become widely used in fishery management, where it is usually treated as a statistical quantity. Here, we investigate the reproductive ecology of steepness, using both unstructured and age-structured models. We show that if one has sufficient information to construct a density-independent population model (maximum per capita productivity and natural mortality for the unstructured case or maximum per capita productivity, natural mortality and schedules of size and maturity at age for the structured model) then one can construct a point estimate for steepness. Thus, steepness cannot be chosen arbitrarily. If one assumes that the survival of recruited individuals fluctuates within populations, it is possible, by considering the early life history, to construct a prior distribution for steepness from this same demographic information. We develop the ideas for both compensatory (Beverton‐Holt) and over-compensatory (Ricker) stock‐recruitment relationships. We illustrate our ideas with an example concerning bluefin tuna (Thunnus thynnus/ orientalis, Scombridae). We show that assuming that steepness is unity when recruitment is considered to be environmentally driven is not biologically consistent, is inconsistent with a precautionary approach, and leads to the wrong scientific inference (which also applies for assigning steepness any other single value).
Reducing deaths from tuberculosis in antiretroviral treatment programmes in sub-Saharan Africa

Mortality rates are high in antiretroviral therapy (ART) programmes in sub-Saharan Africa, especially during the first few months of treatment. Tuberculosis (TB) has been identified as a major underlying cause. Under routine programme conditions, between 5 and 40% of adult patients enrolling in ART services have a baseline diagnosis of TB. There is also a high TB incidence during the first few months of ART (much of which is prevalent disease missed by baseline screening) and long-term rates remain several-folds higher than background. We identify three groups of patients entering ART programmes for which different interventions are required to reduce TB-related deaths. First, diagnostic screening is needed in patients who have undiagnosed active TB so that timely anti-TB treatment can be started. This may be greatly facilitated by new diagnostic assays such as the Xpert MTB/RIF assay. Second, patients with a diagnosis of active TB need optimized case management, which includes early initiation of ART (with timing now defined by randomized controlled trials), trimethoprim–sulphamethoxazole prophylaxis and treatment of comorbidity. Third, all remaining patients who are TB-free at enrolment have high ongoing risk of developing TB and require preventive interventions, including optimized immune recovery (with ART ideally started early in the course of HIV infection), isoniazid preventive therapy and infection control to reduce infection risk. Further specific measures are needed to address multidrug-resistant TB (MDR-TB). Finally, scale-up of all these interventions requires nationally and locally tailored models of care that are patient-centred and provide integrated healthcare delivery for TB, HIV and other comorbidities.
Intrapleural targeted therapies (anti-VEGF and anti-EGFR) in the model of malignant pleural effusion

Rationale Malignant pleural effusion has few options of treatment and drugs administrated by different routes can lead to a less permissive microenvironment for the development of malignant pleural disease. Objectives To analyze therapies administered intrapleurally in malignant pleural disease and to study EGFR and KRAS mutations in adenocarcinoma. Methods Mice received LLC cells and were treated intrapleurally with anti-VEGF, anti-EGFR, anti-VEGF+anti-EGFR or saline. Animal survival, weight and mobility, volume, biochemistry and immunology of fluid, gene expression, KRAS and EGFR mutation were evaluated. Results All animals developed malignant effusion and presented progressive weight loss without difference between groups; however, groups treated with anti-EGFR were more active. No difference in mortality was observed. Temporal increase of volume and inflammatory markers was observed mainly in the untreated group. Gene expression in tumors was overexpressed in VEGF, EGFR and KRAS compared with normal tissue. Mutation in exon 2 of the KRAS gene was observed. Conclusions Intrapleural Anti-VEGF and/or anti-EGFR reduced volume and inflammatory mediators in pleural fluid. Anti-EGFR and anti-VEGF+anti-EGFR decreased morbidity although without impact on survival. LLC tumors presented KRAS mutation, this could have influenced the action of these therapies.
HIV seroprevalence surveys in drug treatment centers.

Sharing of equipment used to inject illicit drugs intravenously is a risk factor for human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS). Systematic surveillance of HIV infection among intravenous drug users (IVDUs) in the United States is essential to monitor the HIV epidemic and to target and evaluate prevention programs for IVDUs and their partners. The most accessible segment of the largely covert population of IVDUs are those in drug treatment programs. In collaboration with State and local health departments and drug abuse treatment agencies, the Centers for Disease Control is conducting blinded (serologic test results not linked to identifiable persons) and nonblinded (in which clients voluntarily agree to participate) surveys of IVDUs entering drug treatment in 39 U.S. metropolitan areas. The same protocol is used in all participating drug treatment centers. Blinded surveys will be carried out annually to determine HIV seroprevalence rates in eligible IVDUs entering drug treatment and to monitor trends over time. Each year, nonblinded surveys of IVDUs entering drug treatment will assess self-reported drug use and sexual behaviors to help design educational interventions and to detect changes in behavior over time. This sentinel surveillance system, using a standardized methodology, will provide the best national and regional data available on the seroprevalence of HIV among IVDUs and the relationships of drug use, sexual behaviors, and HIV serologic status of IVDUs.
Fast sequential floating forward selection applied to emotional speech features estimated on DES and SUSAS data collections

In this paper, we classify speech into several emotional states based on the statistical properties of prosody features estimated on utterances extracted from Danish Emotional Speech (DES) and a subset of Speech Under Simulated and Actual Stress (SUSAS) data collections. The proposed novelties are in: 1) speeding up the sequential floating feature selection up to 60%, 2) applying fusion of decisions taken on short speech segments in order to derive a unique decision for longer utterances, and 3) demonstrating that gender and accent information reduce the classification error. Indeed, a lower classification error by 1% to 11% is achieved, when the combination of decisions is made on long phrases and an error reduction by 2%-11% is obtained, when the gender and the accent information is exploited. The total classification error reported on DES is 42.8%. The same figure on SUSAS is 46.3%. The reported human errors have been 32.3% in DES and 42% in SUSAS. For comparison purposes, a random classification would yield an error of 80% in DES and 87.5% in SUSAS, respectively.
Evaluating a Wide-Coverage CCG Parser

This paper compares three evaluation metrics for a CCG parser trained and tested on a CCG version of the Penn Treebank. The standard Parseval metrics can be applied to the output of this parser; however, these metrics are problematic for CCG, and a comparison with scores given for standard Penn Treebank parsers is uninformative. As an alternative, we consider two evaluations based on headdependencies; one considers local dependencies defined in terms of the derivation tree, and one considers dependencies defined in terms of the CCG categories. The latter set of dependencies includes long-range dependencies such as those inherent in coordination and extraction phenomena.
Birth Order, Schooling, and Earnings

Birth-order effects are posited by many to affect earnings and schooling. We show how such effects can be interpreted to shift either the earnings possibility frontier for siblings or parental preferences. We find empirical evidence for birth-order effects on (age-adjusted) schooling and on earnings for young U.S. adults, though the latter is not robust for all specifications. The examination of intrahousehold allocations suggests that these birth-order differences occur despite parental preferences or prices by birth order favoring later borns, apparently because of stronger endowment effects that favor firstborns.
Disorders of carbohydrate absorption in childhood

Until the last decade emphasis was placed on fat malabsorption as the principal dietary cause of persistent diarrhoea in childhood. That abnormalities of the absorption of sugar could be responsible had not been widely realized and it is only 12 years since Holzel, Schwarz, and Sutcliffe (1959) in Manchester described familial congenital lactose intolerance; 11 years since Weijers, van de Kamer, Mossel, and Dicke (1960) described fermentative diarrhoea due to dietary sucrose; and nine years since Anderson, Messer, Townley, Freeman, and Robinson (1962) gavethe first demonstrationthat thedisaccharidasessucrase and isomaltase-were not present in the small-intestinal mucosa of two siblings who presented with persistent watery diarrhoea which disappeared on withdrawing sucrose from the diet. However, now we recognize a wide variety ofprimary and secondary types of sugar intolerance involving both disaccharides and monosaccharides and these are outlined in Table I.
Energy Efficiency in Cache-Enabled Small Cell Networks With Adaptive User Clustering

Using a network of cache enabled small cells, traffic during peak hours can be reduced by proactively fetching the content that is most likely to be requested. In this paper, we aim to explore the impact of proactive caching on an important metric for future generation networks, namely, energy efficiency (EE). We argue that, exploiting the spatial repartitions of users in addition to the correlation in their content popularity profiles, can result in considerable improvement of the achievable EE. In this paper, the optimization of EE is decoupled into two related subproblems. The first one addresses the issue of content popularity modeling. While most existing works assume similar popularity profiles for all users, we consider an alternative framework in which, users are clustered according to their popularity profiles. In order to showcase the utility of the proposed clustering, we use a statistical model selection criterion, namely, Akaike information criterion. Using stochastic geometry, we derive a closed-form expression of the achievable EE and we find the optimal active small cell density vector that maximizes it. The second subproblem investigates the impact of exploiting the spatial repartitions of users. After considering a snapshot of the network, we formulate a combinatorial problem that optimizes content placement in order to minimize the transmission power. Numerical results show that the clustering scheme considerably improves the cache hit probability and consequently the EE, compared with an unclustered approach. Simulations also show that the small base station allocation algorithm improves the energy efficiency and hit probability.
Fitness Distance Correlation, as statistical measure of Genetic Algorithm difficulty, revisited

This paper revisits past works on fitness distance correlation (FDC) in relation to genetic algorithms (GA) performance, and puts forth evidence that this statistical measure is relevant to predict the performance of a GA. We propose an interpretation of Hamming-distance based FDC, which takes into account the GA dynamics and the effects of crossover operator. We base this proposition on the notion of predicates developed by M. D. Vose. The aim of this article is double since, using results obtained with the FDC, it confirms Vose's theory, and starting from this theory, it corroborates FDC as a relevant predictor measure of problem difficulty for GAs.