Miracle-dz/UniFAR-FTUs huggingface dataset:
Extending the Agile Development Process to Develop Acceptably Secure Software

The agile software development approach makes developing secure software challenging. Existing approaches for extending the agile development process, which enables incremental and iterative software development, fall short of providing a method for efficiently ensuring the security of the software increments produced at the end of each iteration. This article (a) proposes a method for security reassurance of software increments and demonstrates it through a simple case study, (b) integrates security engineering activities into the agile software development process and uses the security reassurance method to ensure producing acceptably secure-by the business owner-software increments at the end of each iteration, and (c) discusses the compliance of the proposed method with the agile values and its ability to produce secure software increments.
Designing siRNA That Distinguish between Genes That Differ by a Single Nucleotide

Small interfering RNAs (siRNAs), the guides that direct RNA interference (RNAi), provide a powerful tool to reduce the expression of a single gene in human cells. Ideally, dominant, gain-of-function human diseases could be treated using siRNAs that specifically silence the mutant disease allele, while leaving expression of the wild-type allele unperturbed. Previous reports suggest that siRNAs can be designed with single nucleotide specificity, but no rational basis for the design of siRNAs with single nucleotide discrimination has been proposed. We systematically identified siRNAs that discriminate between the wild-type and mutant alleles of two disease genes: the human Cu, Zn superoxide dismutase (SOD1) gene, which contributes to the progression of hereditary amyotrophic lateral sclerosis through the gain of a toxic property, and the huntingtin (HTT) gene, which causes Huntington disease when its CAG-repeat region expands beyond approximately 35 repeats. Using cell-free RNAi reactions in Drosophila embryo lysate and reporter assays and microarray analysis of off-target effects in cultured human cells, we identified positions within an siRNA that are most sensitive to mismatches. We also show that purine:purine mismatches imbue an siRNA with greater discriminatory power than other types of base mismatches. siRNAs in which either a G:U wobble or a mismatch is located in the “seed” sequence, the specialized siRNA guide region responsible for target binding, displayed lower levels of selectivity than those in which the mismatch was located 3′ to the seed; this region of an siRNA is critical for target cleavage but not siRNA binding. Our data suggest that siRNAs can be designed to discriminate between the wild-type and mutant alleles of many genes that differ by just a single nucleotide.
Inter-organizational digital divide: Civic groups' media strategies in the Trinity River Corridor Project

This study’s goals are 1) to investigate how leaders of civic groups make decisions about using new and social media versus older media forms of media, and 2) to reexamine major theses on the social effects of new media equipped with a better understanding of civic groups’ internal decision-making. To explore these issues, we conducted interviews with leaders of eight civic groups involved in the Trinity River Corridor development project in Dallas, TX. We also interviewed local journalists, and analyzed the eight civic groups’ web sites, social media sites, and blogs, as well as blogs that linked to the groups’ sites. We find that new and social media were used mainly by organizations that were not directly involved in major political actions, and that for the two groups most directly involved in political actions, the wealthier and more powerful group was better connected to other organizations that did use new and social media. The findings reveal a sharp digital divide between networks of civic organizations.
Toward a Product Search Engine based on User Reviews

We address the problem of developing a method for retrieving products exploiting product user-reviews that can be found on the internet. For this purpose, we introduce a ranking model based on the concept of itemset mining of frequent terms. The prototype search engine that implements the proposed retrieval model is illustrated, and a preliminary evaluation on a real data set is discussed.
Structures of Adenovirus Incomplete Particles Clarify Capsid Architecture and Show Maturation Changes of Packaging Protein L1 52/55k

ABSTRACT Adenovirus is one of the most complex icosahedral, nonenveloped viruses. Even after its structure was solved at near-atomic resolution by both cryo-electron microscopy and X-ray crystallography, the location of minor coat proteins is still a subject of debate. The elaborated capsid architecture is the product of a correspondingly complex assembly process, about which many aspects remain unknown. Genome encapsidation involves the concerted action of five virus proteins, and proteolytic processing by the virus protease is needed to prime the virion for sequential uncoating. Protein L1 52/55k is required for packaging, and multiple cleavages by the maturation protease facilitate its release from the nascent virion. Light-density particles are routinely produced in adenovirus infections and are thought to represent assembly intermediates. Here, we present the molecular and structural characterization of two different types of human adenovirus light particles produced by a mutant with delayed packaging. We show that these particles lack core polypeptide V but do not lack the density corresponding to this protein in the X-ray structure, thereby adding support to the adenovirus cryo-electron microscopy model. The two types of light particles present different degrees of proteolytic processing. Their structures provide the first glimpse of the organization of L1 52/55k protein inside the capsid shell and of how this organization changes upon partial maturation. Immature, full-length L1 52/55k is poised beneath the vertices to engage the virus genome. Upon proteolytic processing, L1 52/55k disengages from the capsid shell, facilitating genome release during uncoating. IMPORTANCE Adenoviruses have been extensively characterized as experimental systems in molecular biology, as human pathogens, and as therapeutic vectors. However, a clear picture of many aspects of their basic biology is still lacking. Two of these aspects are the location of minor coat proteins in the capsid and the molecular details of capsid assembly. Here, we provide evidence supporting one of the two current models for capsid architecture. We also show for the first time the location of the packaging protein L1 52/55k in particles lacking the virus genome and how this location changes during maturation. Our results contribute to clarifying standing questions in adenovirus capsid architecture and provide new details on the role of L1 52/55k protein in assembly.
Evaluation of the learning curve for percutaneous nephrolithotomy.

PURPOSE To determine the number of percutaneous nephrolithotomy (PCNL) operations which are required to achieve competence or excellence. MATERIALS AND METHODS One hundred and five consecutive PCNL operations performed by a fellow in endourology, with no previous experience in performing solo PCNL, were studied. Operation duration, stone extraction percent, stone-free rate, number of access, tubeless cases, and complications were studied in sequential groups of 15 patients as the surgeon gained experience. RESULTS Operation duration decreased from the mean of 95.4 minutes in the first to 15th patients to 78.3 minutes in the 31st to 45th patients, and then remained unchanged. Minor complications were only observed in the first to 45th patients. Stone extraction percent increased from the mean of 88.3% in the first to 15th patients to 99.3% in 91st to 105th patients. Percentage of patients with no residual fragments decreased from 53% in the first to 15th patients to 6.7% in the 91st to 105th patients. No statistically significant differences were observed in estimated blood loss or transfusion rate between sequential groups of subjects. CONCLUSION An improvement in operation duration was observed, and absence of complications was achieved after 45 cases. The improvement in stone clearance was observed up to the last subjects. Competence and excellence were achieved after 45 and 105 operations, respectively.
Mitochondrial Mutations and Polymorphisms in Psychiatric Disorders

Mitochondrial deficiencies with unknown causes have been observed in schizophrenia (SZ) and bipolar disorder (BD) in imaging and postmortem studies. Polymorphisms and somatic mutations in mitochondrial DNA (mtDNA) were investigated as potential causes with next generation sequencing of mtDNA (mtDNA-Seq) and genotyping arrays in subjects with SZ, BD, major depressive disorder (MDD), and controls. The common deletion of 4,977 bp in mtDNA was compared between SZ and controls in 11 different vulnerable brain regions and in blood samples, and in dorsolateral prefrontal cortex (DLPFC) of BD, SZ, and controls. In a separate analysis, association of mitochondria SNPs (mtSNPs) with SZ and BD in European ancestry individuals (n = 6,040) was tested using Genetic Association Information Network (GAIN) and Wellcome Trust Case Control Consortium 2 (WTCCC2) datasets. The common deletion levels were highly variable across brain regions, with a 40-fold increase in some regions (nucleus accumbens, caudate nucleus and amygdala), increased with age, and showed little change in blood samples from the same subjects. The common deletion levels were increased in the DLPFC for BD compared to controls, but not in SZ. Full mtDNA genome resequencing of 23 subjects, showed seven novel homoplasmic mutations, five were novel synonymous coding mutations. By logistic regression analysis there were no significant mtSNPs associated with BD or SZ after genome wide correction. However, nominal association of mtSNPs (p < 0.05) to SZ and BD were found in the hypervariable region of mtDNA to T195C and T16519C. The results confirm prior reports that certain brain regions accumulate somatic mutations at higher levels than blood. The study in mtDNA of common polymorphisms, somatic mutations, and rare mutations in larger populations may lead to a better understanding of the pathophysiology of psychiatric disorders.
A CAMPARISON OF STUDENT ’ S ACADEMIC PERFORMANCE AND BEHAVIORAL ABNORMALITIES AMONG VIEWERS AND NON-VIEWERS OF SATELLITE PROGRAMS IN BANDAR ABBAS

The present study tried to compare the academic performance and behavioral abnormalities among viewers and non-viewers of satellite programs in girl conservatory schools located at district 1 of Bandar Abbas city. The methodology for this study was of ex-post-facto type. Our study sample consisted of 400 students who were randomly selected. The instrument used in this study was behavioral abnormalities questionnaire designed by the researcher. Furthermore, last year GPA and the final average in first term of school year represented the educational status of students. The results showed that there was a difference between academic performance (last year GPA and final average in first term) of girl students who had viewed satellite programs and girl students who had not viewed those programs. However, there was no difference among the academic performance (continuous performance GPA) of girl students who had viewed satellite programs and girl students who had not viewed those programs. Also, there was a significant difference between the behavioral abnormalities and its related dimensions among girl students who had viewed satellite programs and gir l students who had not viewed those programs.
Postoperative analgesia in infants and children.

The structural components necessary to perceive pain are already present at about 25 weeks gestation whereas the endogenous descending inhibitory pathways are not fully developed until mid-infancy. 4 164 Opioid and other receptors are much more widely distributed in fetuses and neonates. 53 62 66 127 Fetuses subjected to intrauterine exchange transfusion with needle transhepatic access will show both behavioural signs of pain as well as a hormonal stress response. Significant pain stimulation without proper analgesia, for example circumcision, will not only cause unacceptable pain at the time of the intervention but will produce a ‘pain memory’ as illustrated by an exaggerated pain response to vaccination as long as 6 months following the circumcision. Both neonates and infants are able to mount a graded hormonal stress response to surgical interventions and adequate intraand postoperative analgesia will not only modify the stress response but has also been shown to reduce morbidity and mortality. 3 5 6 16 17 163 167
New Resonant Inverter Tuning for Three-Phase Current Source Parallel Resonant Inverters

This paper presents a new tuningloop for three-phase current source parallel resonant inverters. The switching frequency is tuned by using a phase-locked loop (PLL) circuit based on a new Phase Detector (PD). In practice, the resonant capacitors and inductors have tolerances that cause different resonant frequency for each phase. This paper shows that a conventional PDcauseshigher voltage stress over switches and DC-link inductor. In the proposed tuning loop, the PLL tracks the average value of the resonant frequencies that reduces the voltage stress. In addition, there is no feedback from the loadcurrents to detect the phase error, which is another advantage of the new method. A laboratory prototype of a three-phase current source parallel resonant half-bridge inverter was built to verify the advantages of the proposed tuning system with operating frequency of 22 kHz.
Experimental analysis of dynamic algorithms for the single source shortest paths problem

In this paper we propose the first experimental study of the fully dynamic single-source shortest-paths problem on directed graphs with positive real edge weights. In particular, we perform an experimental analysis of three different algorithms: Dijkstra's algorithm, and the two output bounded algorithms proposed by Ramalingam and Reps in [30] and by Frigioni, Marchetti-Spaccamela and Nanni in [18], respectively. The main goal of this paper is to provide a first experimental evidence for: (<i>a</i>) the effectiveness of dynamic algorithms for shortest paths with respect to a traditional static approach to this problem; (<i>b</i>) the validity of the theoretical model of output boundedness to analyze dynamic graph algorithms. Beside random generated graphs, useful to capture the "asymptotic" behavior of the algorithms, we also developed experiments by considering a widely used graph from the real world, i.e., the Internet graph.
Locating objects in virtual reality – the effect of visual properties on target acquisition in unrestrained reaching

Locating objects in virtual space is not the same as locating them in physical space. The visual properties of the virtual object can affect the perception of its spatial location, and hence the ability to accurately co-locate the hand and the object. This paper presents an investigation into the effects of object geometry and proximity brightness cues on the time-to-target of a virtual reality reaching and grasping task. Time-to-target was significantly affected by object geometry, but not by brightness cues. We conclude that object geometry needs to be carefully considered for applications where accurate co-location of hand and object are important.
Delta self-consistent field method to obtain potential energy surfaces of excited molecules on surfaces

We present a modiﬁcation of the (cid:1) self-consistent ﬁeld (cid:1) (cid:1) SCF (cid:2) method of calculating energies of excited states in order to make it applicable to resonance calculations of molecules adsorbed on metal surfaces, where the molecular orbitals are highly hybridized. The (cid:1) SCF approximation is a density-functional method closely resembling standard density-functional theory (cid:1) DFT (cid:2) , the only difference being that in (cid:1) SCF one or more electrons are placed in higher lying Kohn-Sham orbitals instead of placing all electrons in the lowest possible orbitals as one does when calculating the ground-state energy within standard DFT. We extend the (cid:1) SCF method by allowing excited electrons to occupy orbitals which are linear combinations of Kohn-Sham orbitals. With this extra freedom it is possible to place charge locally on adsorbed molecules in the calculations, such that resonance energies can be estimated, which is not possible in traditional (cid:1) SCF because of very delocalized Kohn-Sham orbitals. The method is applied to N 2 , CO, and NO adsorbed on different metallic surfaces and compared to ordinary (cid:1) SCF without our modiﬁcation, spatially constrained DFT, and inverse-photoemission spectroscopy measurements. This comparison shows that the modiﬁed (cid:1) SCF method gives results in close agreement with experiment, signiﬁcantly closer than the comparable methods. For N 2 adsorbed on ruthenium (cid:1) 0001 (cid:2) we map out a two-dimensional part of the potential energy surfaces in the ground state and the 2 (cid:2) resonance. From this we conclude that an electron hitting the resonance can induce molecular motion, optimally with 1.5 eV transferred to atomic movement. Finally we present some performance test of the (cid:1) SCF approach on gas-phase N 2 and CO in order to compare the results to higher accuracy methods. Here we ﬁnd that excitation energies are approximated with accuracy close to that of time-dependent density-functional theory. Especially we see very good agreement in the minimum shift of the potential energy surfaces in the excited state compared to the ground state.
Distinct population structure for co-occurring Anopheles goeldii and Anopheles triannulatus in Amazonian Brazil

To evaluate whether environmental heterogeneity contributes to the genetic heterogeneity in Anopheles triannulatus, larval habitat characteristics across the Brazilian states of Roraima and Pará and genetic sequences were examined. A comparison with Anopheles goeldii was utilised to determine whether high genetic diversity was unique to An. triannulatus. Student t test and analysis of variance found no differences in habitat characteristics between the species. Analysis of population structure of An. triannulatus and An. goeldii revealed distinct demographic histories in a largely overlapping geographic range. Cytochrome oxidase I sequence parsimony networks found geographic clustering for both species; however nuclear marker networks depicted An. triannulatus with a more complex history of fragmentation, secondary contact and recent divergence. Evidence of Pleistocene expansions suggests both species are more likely to be genetically structured by geographic and ecological barriers than demography. We hypothesise that niche partitioning is a driving force for diversity, particularly in An. triannulatus.
STUDY OF THE ROLE OF QUALITY AND SELF-EFFICACY OF KNOWLEDGE MANAGEMENT SYSTEM AND ORGANIZATIONAL CLIMATE IN THE PROCESS OF DEVELOPMENT OF NEW SERVICES IN BANK TEJARAT

The current study is aimed at investigating the quality, self-efficacy of the management system and organizational climate in the process of development of new services in Bank Tejarat. This study is of applied type as far as its goal is concerned and is of descriptive and survey type as far as the study method is concerned. The statistical society consists of all the staff of branches of Bank Tejrarat, Tehran province who were 1100. To determine the sample, classified sampling was used and the sample volume was decided to be 300. 290 questionnaires were returned and studied. The method to collect data was survey and the measurement tool was a questionnaire. The validity of the questionnaire was confirmed as acceptable using conceptual and configurative method and the reliability of the measurement was confirmed through Cronbach's Alpha as 0.850. To collect data, the standardized questionnaire (Chen et al., 2012) was used. To analyze the data, firstly Lisrel software was used to find out whether the theoretical model was acceptable and then route coefficient and specified t test were used to analyze the data. The results showed that the model was used for the determined sample and the fitting of the model was acceptable. The results of data analysis showed that the quality of knowledge management system can have positive effect on the personnel's attitude toward knowledge sharing. Self-efficacy of the knowledge management system does not have a positive effect on the staff's attitude toward knowledge sharing. Self-efficacy of knowledge management does not have a positive effect on the goal of knowledge sharing interaction. Good organizational climate has a positive effect on the attitude toward knowledge sharing. Good organizational climate has a positive effect on the goal of knowledge sharing interaction. Good attitude has a positive effect on the goal of knowledge sharing interaction in order to share knowledge.
Chemical Composition, Enantiomeric Analysis, AEDA Sensorial Evaluation and Antifungal Activity of the Essential Oil from the Ecuadorian Plant Lepechinia mutica Benth (Lamiaceae)

This study describes the GC‐FID, GC/MS, GC‐O, and enantioselective GC analysis of the essential oil hydrodistilled from leaves of Lepechinica mutica (Lamiaceae), collected in Ecuador. GC‐FID and GC/MS analyses allowed the characterization and quantification of 79 components, representing 97.3% of the total sample. Sesquiterpene hydrocarbons (38.50%) and monoterpene hydrocarbons (30.59%) were found to be the most abundant volatiles, while oxygenated sesquiterpenes (16.20%) and oxygenated monoterpenes (2.10%) were the minor components. In order to better characterize the oil aroma, the most important odorants, from the sensorial point of view, were identified by Aroma Extract Dilution Analysis (AEDA) GC‐O. They were α‐Pinene, β‐Phellandrene, and Dauca‐5,8‐diene, exhibiting the characteristic woody, herbaceus, and earthy odors, respectively. Enantioselective GC analysis of L. mutica essential oil revealed the presence of twelve couples and two enantiomerically pure chiral monoterpenoids. Their enantiomeric excesses were from a few percent units to 100%. Moreover, the essential oil exhibited moderate in vitro activity against five fungal strains, being especially effective against M. canis, which is a severe zoophilic dermatophyte causal agent of pet and human infections.
A ug 2 01 0 A 2-Planar Algebras

We give a diagrammatic presentation of the A2-Temperley-Lieb algebra. Generalizing Jones’ notion of a planar algebra, we formulate an A2-planar algebra motivated by Kuperberg’s A2-spider. This A2-planar algebra contains a subfamily of vector spaces which will capture the double complex structure pertaining to the subfactor for a finite SU(3) ADE graph with a flat cell system, including both the periodicity three coming from the A2-Temperley-Lieb algebra as well as the periodicity two coming from the subfactor basic construction. We use an A2-planar algebra to obtain a description of the (Jones) planar algebra for the Wenzl subfactor in terms of generators and relations. Mathematics Subject Classification 2000: Primary 46L37; Secondary 46L60, 81T40.
Reconstruction with the calibrated SYCLOP sensor

In this paper we present a method of calibrating the omnidirectional sensor used in our laboratory and named SYCLOP ("Conic System for Localization and Perception"). In order to have better precision than that obtained in classical applications using this kind of sensor, we highlight the importance of calibration for the whole sensor. After this step we validate our model by a reconstruction of objects, and of an environment from two different methods, the first based on a commercial software 3DS Max/sup (R)/ and the second based on a simulator developed by us and taking parameters determined in the previous stage. The real and calculated pictures are compared, to estimate the error of reconstruction. The last part of this paper presents results obtained with the SYCLOP simulator and an experimental phase.