Miracle-dz/UniFAR-FTUs huggingface dataset:
Multiple lesions in receptor tyrosine kinase pathway determine glioblastoma response to pan-ERBB inhibitor PF-00299804 and PI3K/mTOR dual inhibitor PF-05212384

A novel pan ERBB inhibitor PF-00299804 (dacomitinib) is currently in phase II clinical trials in glioblastoma multiforme (GBM) patients; however its pre-clinical efficacy in GBMs has not been tested. In this study, we evaluated the efficacy of dacomitinib alone or in combination with PI3K/mTOR dual inhibitor PF-05212384 in GBM and assessed the mechanisms of resistance and the molecular determinants of response. A panel of established and patient derived primary GBM lines that present different molecular profiles and also the GBM lines engineered to express EGFRvIII mutant or PTEN were treated with either dacomitinib, PF-05212384, or combination and assessed for their viability and changes in EGFR/PI3K/mTOR signaling. We show that dacomitinib significantly reduced phosphorylated EGFR in all the GBM lines but did not show a dose-dependent response on cell viability in a majority of the lines tested. Multiple lesions in the receptor tyrosine kinases (RTKs) pathway including PTEN mutation, co-activation of RTKs, and EGFRvIII mutation resulted in unaltered active status of PI3K/mTOR in the GBM lines even in the presence of EGFR inhibition. Blocking PI3K/mTOR dramatically inhibited cell proliferation in most GBM lines and enhanced dacomitinib induction of apoptosis in a GBM line that has both EGFR amplification and EGFR-independent PI3K activation. These data suggest molecular profiling of EGFR/PI3K/PTEN status to select GBM patients for EGFR or/and PI3K/mTOR targeted therapies.
Art in Nursing Research

The purpose of this column is to present the plan of a research project involving researchers, artists, and research participants. The planned research project will explore with the Parse method eight universal lived experiences important to persons in community. It is anticipated that art works will complement story and text in order to enhance understanding. The authors here present the first attempt of including an embedded artist with Parse method involving one participant who spoke about her experience of feeling respected-not respected. Researcher text and artist works are shown to enhance meaning and understanding.
Wave-equation migration velocity analysis beyond the Born approximation: 72nd Ann

Production of a low mineral content fuel by a coal liquefaction process utilizing a hydrogenated coal solvent having been hydrogenated to remove at least about 80% of the asphaltenes which yields as the primary product a mixture of liquid and solids, a part of which is suspended in the liquid. The suspended solids are effectively removed with minimum loss of desired product by means of a light aromatic solvent in combination with a hydrogenated coal solvent having been hydrogenated to remove at least about 80% of the asphaltenes with a weight ratio of unreacted coal oil solvent to light aromatic solvent of from about 0.1 to about 1000.
Designing an Integrated Bookmark / History System for Web Browsing

Current commercial web browsers such as Netscape Navigator and Microsoft Internet Explorer attempt to make it easier for users to return to previously visited web pages. They offer three separate but important facilities: the back button, a bookmark system, and a history list. However, research indicates that users are not utilizing all of these systems effectively. In this paper, we present a single integrated history that unifies functionality similar to the back button, bookmarks and history lists. We also show how these mechanisms can be improved upon. We pay special attention to the ways pages are presented within a display, and on providing lightweight means for marking, recalling, and revisiting pages. The prototype we are developing works within Microsoft Internet Explorer. It presents a history list that represents pages by visual thumbnails as well as titles and URLs. It incorporates bookmark functions through a dog-ear metaphor, and it contains methods to filter a history list. Finally, it is tightly linked with the back/forward buttons.
A rare case of hepatoid carcinoma of the ovary with pancytopenia and hypocellular marrow

REFERENCES 1. Lin TS, Shen FM. Trace metals in Chinese joss stick smoke. Bull Environ Contam Toxicol 2003;71:135-41. 2. Chuang HC, BéruBé K, Lung SC, Bai KJ, Jones T. Investigation into the oxidative potential generated by the formation of particulate matter from incense combustion. J Hazard Mater 2013;244-245:142-50. 3. Lung SC, Kao MC. Worshippers’ exposure to particulate matter in two temples in Taiwan. J Air Waste Manag Assoc 2003;53:130-5. 4. Kuo CY, Yang YH, Chao MR, Hu CW. The exposure of temple workers to polycyclic aromatic hydrocarbons. Sci Total Environ 2008;401:44-50. 5. Maspat V. Health risk assessment of workers exposure to BTEX from Chinese smoke at worship places in Bangkok. Bangkok: Chulalongkorn University; 2013. 6. Liou SH, Yang JL, Cheng SY, Lai FM. Respiratory symptoms and pulmonary function among wood dust-exposed joss stick workers. Int Arch Occup Environ Health 1996;68:154-60. Sir,
Child Caregivers’ Contingent Responsiveness Behaviors During Interactions With Toddlers Within Three Day Care Contexts

Increasingly, children spend much of their day in the care of adults other than their parents, such as child care providers. Consequently, it is important to analyze nonparental adults’ use of strategies suggested to foster language development, such as contingent responsiveness, during interactions with young children. This study examined child caregivers’ contingent responsiveness behaviors that followed toddlers’ communicative attempts within unstructured, semistructured, and structured daycare contexts. Child caregiver behaviors were coded as (a) no response (appropriate), (b) no response (inappropriate), (c) noncontingent response (appropriate), (d) noncontingent response (inappropriate), (e) contingent response and termination of the interaction (appropriate), (f) contingent response and termination of the interaction (inappropriate), and (g) contingent response leading to maintenance of the communicative interaction. Important similarities and differences in child caregivers’ contingent responsiveness behaviors for the three contexts suggest a need to prepare child caregivers to use strategies such as contingent responsiveness across contexts to facilitate language development.
Th2 response polarization during infection with the helminth parasite Schistosoma mansoni

Summary: T‐helper 2 (Th2) cell responses play a critical role in protection against helminth infections. In the case of Schistosoma mansoni, an important helminth parasite of man, data from a mouse model of human disease have shown that Th2 responses are essential to allow host survival. In this infection, parasite eggs are the primary stimulus for Th2 response development. Recent work has shown that egg molecules exert multiple levels of control over the development of host interferon‐γ‐associated inflammatory responses. Soluble egg antigen inhibits the ability of dendritic cells to make interleukin‐12 and induces Th2‐polarized adaptive immune responses that in combination with regulatory T‐cell responses effectively limit Th1 response development. In this article, we discuss the factors influencing Th2 response polarization during infection with S. mansoni.
Comportamiento ciudadano organizacional y RSE

Se analiza el comportamiento ciudadano de trabajadores que participan en proyectos de voluntariado promovidos por su empresa como parte de la responsabilidad social empresarial. Se evalua si esa participacion desarrolla en los colaboradores actitudes diferentes de las de quienes no participan en este tipo de proyectos. La investigacion, cumplida en una empresa alimentaria mexicana que adelanta proyectos de RSE en los campos comunitario, ambiental y de calidad de vida en el trabajo, encontro que los participantes en ese voluntariado muestran rasgos de conciencia ciudadana que benefician a la organizacion en su conjunto, ademas de contribuir a los objetivos especificos de su proyecto
Clostridium paraputrificum Bacteremia Associated with Colonic Necrosis in a Patient with AIDS

Clostridium species are anaerobic Gram-positive rods that can cause a broad range of invasive infections in humans, including myonecrosis and bacteremia. Importantly, clostridial bacteremia is frequently associated with underlying medical conditions, such as colonic malignancy. Characterizing Clostridium spp. and understanding their associated clinical disease spectrum are paramount to provide optimal treatment, thereby decreasing morbidity and mortality especially in those with underlying debilitating comorbidities. Clostridium paraputrificum is an infrequently isolated Clostridium species and its clinical significance has not been well described. We herein report a case of bacteremia due to C. paraputrificum in a 65-year-old man with AIDS who developed acute colonic necrosis complicated by septic shock. We then review other cases of bacteremia associated with C. paraputrificum in the literature in addition to discussing the clinical significance of anaerobic bacteremia in general. To our knowledge, our report is the second case of C. paraputrificum bacteremia in a patient with AIDS.
A MapReduce based ISODATA algorithm

Cluster analysis is a mathematical method that applied in various fields, such as biology, medicine, business and marketing. ISODATA algorithm is a Clustering algorithm that has been widely used. With the development of information technology, data set expanded dramatically which becomes a great challenge to the traditional algorithm. Parallel computing is one of the main methods to solve such problem. We have proposed a Parallel ISODATA algorithm based on MapReduce which is a famous distributed computing framework. Experiments show that it greatly improves the efficiency of the algorithm.
Single Cell Analysis Linking Ribosomal (r)DNA and rRNA Copy Numbers to Cell Size and Growth Rate Provides Insights into Molecular Protistan Ecology

Ribosomal (r)RNA and rDNA have been golden molecular markers in microbial ecology. However, it remains poorly understood how ribotype copy number (CN)‐based characteristics are linked with diversity, abundance, and activity of protist populations and communities observed at organismal levels. Here, we applied a single‐cell approach to quantify ribotype CNs in two ciliate species reared at different temperatures. We found that in actively growing cells, the per‐cell rDNA and rRNA CNs scaled with cell volume (CV) to 0.44 and 0.58 powers, respectively. The modeled rDNA and rRNA concentrations thus appear to be much higher in smaller than in larger cells. The observed rRNA:rDNA ratio scaled with CV0.14. The maximum growth rate could be well predicted by a combination of per‐cell ribotype CN and temperature. Our empirical data and modeling on single‐cell ribotype scaling are in agreement with both the metabolic theory of ecology and the growth rate hypothesis, providing a quantitative framework for linking cellular rDNA and rRNA CNs with body size, growth (activity), and biomass stoichiometry. This study also demonstrates that the expression rate of rRNA genes is constrained by cell size, and favors biomass rather than abundance‐based interpretation of quantitative ribotype data in population and community ecology of protists.
Digit ratio (2D:4D) and lateralization for basic numerical quantification

Abstract. The ratio between the second and fourth fingers (2D:4D) is supposed to serve as a putative indicator of prenatal testosterone (PT). Significant associations between 2D:4D, children's basic numerical ability, and the Spatial Numerical Associations of Response Codes (SNARC) effect have recently been reported. The present study explored potential relationships between 2D:4D and the basic numerical ability of subitizing (the rapid enumeration of small quantities) in 80 right-handed adult volunteers. Participants completed a short battery of computerized subitizing and color recognition control tasks with both left and right hands, independently (order counterbalanced). Findings revealed a significant interaction between sex and 2D:4D on reaction time differences for right vs. left hand responses to the subitizing task. While 2D:4D in women showed a significant negative association with a right-hand advantage for the task, a nonsignificant trend in the opposite direction was observed for men. Results.
Chinese Employees Negotiating Differing Conflict Management Expectations in a U.S.-Based Multinational Corporation Subsidiary in Southwest China

This article explores Chinese employees’ views of conflict management norms and their coping strategies in a U.S.-based multinational corporation (MNC) subsidiary in inland China. Twenty-seven interviews were conducted with employees of a renowned large-scale American Information Technology (IT) company in Chengdu, the capital city of Sichuan province in Southwest China. The findings showed that the company’s norm of conflict management is constructive confrontation, and the Chinese employees have contradictory attitudes when they are required to adopt it in everyday conflict management. During the process, the local employees bear burdens to conform to the MNC norms and culture, and have developed coping strategies such as switching mode, seeking hard facts, resorting to off-line talk, and turning to a third party of higher authority for intervention.
Views on Visualization

The field of visualization is maturing. Many problems have been solved and new directions are sought. In order to make good choices, an understanding of the purpose and meaning of visualization is needed. In this paper, visualization is considered from multiple points of view. First, a technological viewpoint is adopted, where the value of visualization is measured based on effectiveness and efficiency. An economic model of visualization is presented and benefits and costs are established. Next, consequences and limitations of visualization are discussed (including the use of alternative methods, high initial costs, subjectiveness, and the role of interaction). Example uses of the model for the judgment of existing classes of methods are given to understand why they are or are not used in practice. However, such an economic view is too restrictive. Alternative views on visualization are presented and discussed: visualization as an art, visualization as design and, finally, visualization as a scientific discipline.
Online Interstate Student Diplomats Discuss What Justifies War: “We Don’t Want People to Die, but We Don’t Want to Lose Our Oil.”

Given that most research in online discussion addresses asynchronous discussions and that middle school students receive little opportunity to engage in sustained, substantive dialogues, there is a need to develop and pilot ways to instructional support students in sustained, online synchronous discussions about public policy issues such as why nations go to war. This article presents: a blended learning instructional model for an online synchronous discussion that was developed and piloted; instructional and logistical issues raised with the model; suggestions on conducting interschool online discussions to promote students’ online voice; and, samples of students’ thinking about what justifies war.
Exploring regular reversibility in Watson-Crick finite automata *

Watson-Crick finite automata were inspired by formal language theory, finite states machines and some ingredients from DNA computing such as working with molecules as double stranded complementary strings. Here, we define different kinds of regular reversibility in this model. Mainly, we will explore regular reversibility in the upper (lower) strand and in the double strand.
Lectin interactions with α‐galactosylated xenoantigens

α‐Galactosylated xenoantigens (Galα1‐3Galβ1‐4GlcNAcβ1 and Galα1‐3Galβ1‐4GlcNAcβ1‐3Galβ1‐4Glc) are often detected with the α‐Gal specific lectin Griffonia simplicifolia 1 isolectin B4 (GS1 B4). However, this lectin exhibits a broad and variable specificity for carbohydrates terminating in α‐Gal. Thus, both false positive and false negative results may occur when GS1 B4 is used to determine natural antigens in xeno (pig‐to‐primate) transplantation research. To refine the tools for detecting α‐galactosylated antigens we have studied the binding of various α‐galactophilic lectins to α‐galactosylated neoglycoproteins. The lectins were: Euonymus europaeus agglutinin (EEA), Griffonia simplicifolia 1 isolectin B4 (GS1 B4), Maclura pomifera agglutinin (MPA) and Pseudomonas aeruginosa agglutinin (PA‐IL). Although both GS1 B4 and MPA strongly bound glycoconjugates terminating in Gal there seems to be some differentiation in their sugar binding preferences. MPA was the only lectin that showed high affinity for the pentasaccharide Galα1‐3Galβ1‐4GlcNAcβ1‐3Galβ1‐4Glc and for the Galα‐glycans on non‐primate thyroglobulin. The length of the xenoantigenic carbohydrate chain may influence the nature of the inhibition when a simple sugar is used to inhibit GS1 B4 binding to the xenoantigen. Inhibition studies of MPA GS1 B4 interaction further suggest that both lectins attach to the same site of the carbohydrate antigen and that GS1 B4 in addition binds to at least one other site that has no affinity for MPA. When lectins are used for recognition and investigation of natural Galα‐antigens, we propose that GS1 B4 and MPA should accompany each other.
Effects of Spatial Scale on Cognitive Play in Preschool Children

This study examines the effects of a scale-reduced play environment on temporal aspects of play behavior. Specifically, it examines the amount of time required to enter complex forms of play, the length of play segments, and the percentage of total play time spent in complex play under normal environmental conditions (full-size, control) and under scale-reduced environmental conditions (experimental). Eleven subjects (mean age of 4 years 2 months) were observed during unstructured play activity with playdough in a small-n, A-B-A-B design. Subjects served as their own controls and were self-motivated relative to the activity. The play structure (scale-reduced environment) consisted of a screened wooden frame 7' (L) x 5' (W) x 5' (H) over a vinyl floor. Results indicate subjects enter complex forms of play more quickly, engage in play segments of longer duration and tend to spend a slightly greater percentage of their overall play time in complex play under experimental conditions, as hypothesized. This stu.
Generalized Partial Test Case Generation Method

Finite State Machines (FSMs) are widely used to generate test case suites for critical systems. Several test case generation methods are derived from the well-known W-method. The Wp-method is a variation of the W-method, which produces smaller test suites. The G-method is a generalization of the W-method, which dispenses the use of characterization sets. In this paper, we combine ideas of both, and introduce a new generalized method, that does not depend on characterization sets, as the Wp-method does, and may produce smaller test suites than those of the G-method.
Incentivizing Reliability in Demand-Side Response

We study the problem of incentivizing reliable demand-response in modern electricity grids. Each agent is uncertain about her future ability to reduce demand and unreliable. Agents who choose to participate in a demand-response scheme may be paid when they respond and penalized otherwise. The goal is to reliably achieve a demand reduction target while selecting a minimal set of agents from those willing to participate. We design incentive-aligned, direct and indirect mechanisms. The direct mechanism elicits both response probabilities and costs, while the indirect mechanism elicits willingness to accept a penalty in the case of non-response. We benchmark against a spot auction, in which demand reduction is purchased from agents when needed. Both the direct and indirect mechanisms achieve the reliability target in a dominant-strategy equilibrium, select a small number of agents to prepare, and do so at low cost and with much lower variance in payments than the spot auction.
Syntactic alignment between computers and people: The role of belief about mental states

People tend to mirror the syntax used by their interlocutors in dialogue. Given that people treat computers as “social actors” in many ways, we might expect them to mirror computers’ syntax as well. We report an experiment in which naive participants played a dialogue game in which they believed that they were interacting with either a person or a computer. In fact, in both cases their “interlocutor” was a computer program that produced pre-scripted utterances. Participants demonstrated a very strong tendency to repeat the syntactic form of their “interlocutor’s” immediately preceding utterance in both conditions. It does not appear that beliefs about the mental states of one’s interlocutor mediate between perception and production.
Successful treatment of refractory seizures with phenobarbital, propofol, and medetomidine following congenital portosystemic shunt ligation in a dog.

OBJECTIVE To report a case of refractory seizures following congenital portosystemic shunt (CPSS) ligation that regained normal neurologic and hepatic function with novel treatment. Medical care included constant rate infusions (CRI) of propofol and medetomidine in conjunction with phenobarbital and supportive intensive care. CASE SUMMARY A 2-year-old neutered male Bichon Frise was diagnosed with a single extrahepatic CPSS based on typical clinical signs, laboratory data, abdominal ultrasound, and computed tomographic angiography. Following initiation of standard medical treatment, a complete surgical ligation of the CPSS was performed. Recovery was uneventful until postligation neurologic dysfunction developed 54 hours after surgery. Seizures were controlled with phenobarbital (6 mg/kg IM q 12 h) and propofol CRI (0.3-0.6 mg/kg/min). Attempts to wean the dog from the propofol CRI resulted in recurrence of seizure activity until the addition of medetomidine CRI (0.016 μg/kg/min) 76 hours after initiation of drug-induced coma allowed gradual discontinuation of the propofol CRI. The dog regained full neurologic and hepatic function and had no further seizure activity apart from a small number of seizure episodes 5 and 22 months later. Adjustments in antiepileptic treatment resulted in no further neurologic dysfunction at 27-month follow-up. NEW OR UNIQUE INFORMATION PROVIDED This report highlights the potential benefit of medetomidine CRI for treatment of postattenuation refractory seizures, which to date have proven impossible to predict and difficult to treat with high mortality rates and persistent neurological deficits in surviving animals. Neuroprotective, drug-sparing, and anti-hypertensive features of medetomidine might improve outcome in postligation refractory seizures. Further investigation and clinical application of medetomidine CRI may improve outcome in this complication of CPSS attenuation.
Coordinate descent iterations in fast affine projection algorithm

We propose a new approach for real-time implementation of the fast affine projection (FAP) algorithm. This is based on exploiting the recently introduced dichotomous coordinate descent (DCD) algorithm, which is especially efficient for solving systems of linear equations on real-time hardware and software platforms since it is free of multiplication and division. The numerical stability of the DCD algorithm allows the new combined DCD-FAP algorithm also to be stable. The convergence and complexity of the DCD-FAP algorithm is compared with that of the FAP, Gauss-Seidel FAP (GS-FAP), and modified GS-FAP algorithms in the application to acoustic echo cancellation. The DCD-FAP algorithm demonstrates a performance close to that of the FAP algorithm with ideal matrix inversion and the complexity smaller than that of the Gauss-Seidel FAP algorithms.