Miracle-dz/UniFAR-FTUs huggingface dataset:
Miniaturizing Floating Traps to Increase RF Safety of Magnetic-Resonance-Guided Percutaneous Procedures

Objective: MRI in the area of cardiovascular catheter-based interventional procedures is an active field. A common intervention—revascularization of chronic total occlusions, requires a conductive guidewire for revascularization. The mechanical properties of guidewires are paramount to the successful execution of such procedures. Furthermore to benefit from MRI techniques, additional conductors are required to transmit signal from the tip of a catheter. Long thin conductors in MRI systems pose a safety risk in the form of RF heating due to induced RF currents on the conductors. Unfortunately many existing techniques to mitigate this risk require physical modification of the conductors, inevitably resulting in detrimental mechanical tradeoffs in the guidewire. This manuscript proposes a novel application and miniaturization of an existing device, the floating RF trap. The RF trap couples strongly to any thin conductor passing through the trap lumen inducing significant series impedance. This results in reduction of induced RF currents, and thus, heating. Methods and Results: This study shows theoretical and experimental analysis of induced impedance as well as theoretical reduction in heating due to various distributions of traps along the length of a catheter. Results of measuring induced current and heating in phantom experiments are also presented. Through comparison with commercial simulation packages and results of phantom experiments, it is shown that miniaturized RF traps can be modeled accurately, including their induced series impedance and effect on induced RF current. Conclusion and Significance: It was demonstrated that floating RF traps present a feasible method to mitigate RF heating while maintaining important mechanical properties of guidewires.
Contributions of Leukocyte Angiotensin-Converting Enzyme to Development of Atherosclerosis

Objective—This study determined the role of angiotensin-converting enzyme (ACE) on the development of angiotensin I–induced atherosclerosis and the contribution of leukocyte-specific expression of this enzyme. Approach and Results—To define the contribution of ACE-dependent activity to angiotensin II synthesis in atherosclerotic development, male low-density lipoprotein receptor−/− mice were fed a fat-enriched diet and infused with either angiotensin I or angiotensin II. The same infusion rate of these peptides had equivalent effects on atherosclerotic development. Coinfusion of an ACE inhibitor, enalapril, ablated angiotensin I–augmented atherosclerosis but had no effect on angiotensin II–induced lesion development. ACE protein was detected in several cell types in atherosclerotic lesions, with a predominance in macrophages. This cell type secreted angiotensin II, which was ablated by ACE inhibition. To study whether leukocyte ACE contributed to atherosclerosis, irradiated male low-density lipoprotein receptor−/− mice were repopulated with bone marrow–derived cells from either ACE+/+ or ACE−/− mice and fed the fat-enriched diet for 12 weeks. Chimeric mice with ACE deficiency in bone marrow–derived cells had modestly reduced atherosclerotic lesions in aortic arches but had no effects in aortic roots. Conclusions—ACE mediates angiotensin I–induced atherosclerosis, and ACE expression in leukocytes modestly contributes to atherosclerotic development in hypercholesterolemic mice.
A New Time Independent Asynchronous Protocol and Its Applications

Communications to, or between, low-end microprocessors within a product always comes at a cost. This paper develops a new, economic solution that will be useful in a variety of cost-sensitive applications. This paper starts by identifying the properties of an inter-microprocessor communications system that adds minimal cost to a product and enables the use of lower price microprocessors. This leads us to introduce a new category of communications called time independent asynchronous (TIA) communications. An economic 2-wire TIA communications protocol is developed and described using timing diagrams. The protocol is modeled using signal transition graphs (STGs), which are found to have some limitations, and so a modification is developed called STG for threads (STG-FT). Two-wire TIA is simulated to confirm livelock and deadlock properties. An implementation is created that verifies the simulation results, and the performance is reported. Finally, a novel application of 2-wire TIA is discussed.
Facebook o los nuevos rostros de la socialidad

El vertiginoso auge de los sitios de redes sociales en linea demuestra que este nuevo formato de interaccion a traves de Internet es una opcion alternativa y eficaz de comunicacion entre los internautas de la generacion digital. El objetivo de este trabajo constituye la exploracion de las implicaciones del uso de redes sociales en linea en terminos de las nuevas formas de socialidad que se crean y responder a la pregunta sobre la construccion de la significacion de esta practica social. Desde la perspectia de la antropologia del ciberespacio y de la etnografia virtual analizaremos -a traves de un estudio de caso a nivel exploratorio entre jovenes los usos y significaciones de la interfaz Facebook en la era digital.
17Beta-estradiol antagonizes effects of 1alpha,25-dihydroxyvitamin D3 on interleukin-6 production and osteoclast-like cell formation in mouse bone marrow primary cultures.

In mouse bone marrow primary cultures, the formation of osteoclast-like, i.e. tartrate-resistant acid phosphatase (TRAP)- and calcitonin receptor-positive multinucleated cells (MNC), when induced by 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2D3), can be suppressed by 17beta-estradiol (17beta-E2), whereas 17alpha-E2 is without any effect. 17beta-E2, above 10(-11) M, significantly reduced 1alpha,25(OH)2D3-mediated TRAP+ MNC formation in cultured bone marrow cells from both female and male mice. The estrogen at 10(-8) M suppressed the peak response to the vitamin D sterol by 50%. 17beta-E2 significantly suppressed basal and 1alpha,25(OH)2D3-stimulated cellular production of interleukin (IL)-6. IL-6 alone, although bone marrow cells in hormone-free culture produced appreciable amounts of the cytokine, did not induce any TRAP+ MNC. Therefore, the changes in IL-6 production induced by the hormones could not be the sole determinant for the extent of TRAP+ MNC formation. However, the stimulatory effect of 1alpha,25(OH)2D3 on osteoclastogenesis nevertheless can be significantly reduced by a neutralizing monoclonal anti-IL-6 antibody. In the presence of 10(-8) M 17beta-E2, the anti-IL-6 monoclonal antibody does not achieve any further suppression of 1alpha,25(OH)2D3-related osteoclast-like cell formation. Our data suggest that induction of osteoclastogenesis by 1alpha,25(OH)2D3 is partially dependent on IL-6 signaling and can be modulated by 17beta-E2 through interference with IL-6 receptor activation, in addition to inhibition of IL-6 production by marrow stromal cells.
Influence of translational efficiency on the stability of the mRNA for ribosomal protein S20 in Escherichia coli

A set of plasmids was constructed so as to contain point mutations which limit the efficiency and/or extent of translation of the gene for ribosomal protein S20. These plasmids were transformed into strains carrying mutations in the genes for polynucleotide phosphorylase (pnp-7), RNase E (rne-1), or both. Subsequently, the effect of translational efficiency on mRNA abundance and chemical half-life was determined. The data indicated that mutations altering translational efficiency also affected mRNA levels over a 10-fold range. This variation in mRNA abundance occurred independently of mutations in either RNase E or polynucleotide phosphorylase, both of which determine the stability of the S20 mRNAs. Moreover, a mutation at codon 15 which caused premature termination of translation of the S20 mRNA did not significantly reduce its stability in different genetic backgrounds. We propose a model in which initiation of translation competes for early steps in mRNA turnover, which could be the binding of RNase E itself or as a complex to one or more sites near the 5' terminus of the S20 mRNA.
Ecient Bulk-loading of Gridles

This paper considers the problem of bulk-loading large data sets for for the grid le multi-attribute indexing technique. We propose a rectilinear partitioning algorithm that heuristically seeks to minimize the size of the grid le needed to ensure no bucket over ows. Empirical studies on both synthetic data sets and on data sets drawn from computational uid dynamics applications demonstrate that our algorithm is very e cient, and is able to handle large data sets. In addition, we present an algorithm for bulk-loading data sets too large to t in main memory. Utilizing a sort of the entire data set it creates a grid le without incurring any over ows. This research was supported by the National Aeronautics and Space Administration under NASA contract NAS1-19480 while the authors were in residence at the Institute for Computer Applications in Science and Engineering (ICASE), NASA Langley Research Center, Hampton, VA 23681-0001. Nicol's work was also supported in part by NSF grant CCR-9210372 and NASA grant NAG-1-1132.
Emerging Standardization

This paper discusses the dynamics associated with the implementation and deployment of an information infrastructure designed to standardize work practices. The analysis is based on a case study conducted in a pharmaceutical R&D organization. The infrastructure in use, comprising a computerized system and surrounding organizational procedures, seems to support work practices not always as originally planned. The paper discusses the role played by local characteristics, contingencies, and practices in shaping a standardization protocol implemented to standardize work practices. Building on actor-network theory, the paper concludes that the standardization of work practices is the result of the dynamic interplay between technology and its users rather than the consequence of a planned and well-defined design project.
Implications of Recovering for Mental Health Systems and Programs.

This presentation outlines the implications of psychiatric disability recovery for mental health systems and programs. Schizophrenia and other serious psychiatric disabilities have been viewed as irreversible illnesses with increasing disability over time. Mental health program planning, policies, and practices have been developed and implemented to support this uncompromisingly negative view of the predicted outcome for people with psychiatric disability. Current research studies report that one-half to two-thirds of people with serious mental illness significantly recover over time. Because of this new and hopeful possibility of recovering, a shift in how systems, programs, and people assist people is required. The first recommendation made is that recovering and the values that support recovering must be strongly affirmed and explicitly identified in the mission statement of the system or program. Additionally, goals and services that support recovering should be identified and affirmed in the mission statement. Along with this, the principles that support the values, goals, and services should be identified and affirmed, as well as cautions in implementing recovering models. Finally, the provision of education and the support of qualitative and quantitative research efforts are essential in assisting people to deal with the barriers and to build in the facilitators. (GCP) Reproductions supplied by EDRS are the best that can be made from the original document. Implications of Recovering for Mental Health Systems and Programs LeRoy Spaniol, Ph.D. APA Presentation, August, 1999 Center for Psychiatric Rehabilitation Boston University 940 Commonwealth Avenue, West Boston, MA 02215 617-353-3549 leroys @bu.edu U.S. DEPARTMENT OF EDUCATION Office of Educational Research and improvement EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC) Thm document has been reproduced as received from the person or organization originating it. O Minor changes have been made to improve reproduction Quality. CD Points ot view or opinions stated in this dOCUment do not necessarily represent official OERI posilion or policy. O CD 2 "PERMISSION TO REPRODUCE THIS MATERIAL HAS BEEN GRANTED BY TO THE EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC). "
Towards a folksonomy solution to support open educational activities and resources in Edu-AREA

Edu-AREA is a Web 2.0 application whose main goal is to contribute to teaching innovation through open educational resources, activities and experiences. AREA provides information in the form of descriptions of educational resources and guidelines of activities that can be used by teachers to create their teaching guides and later to document their classroom experiencies. Teachers can explore the resources, activities, guides and experiences available, select the ones they prefer, create a copy and modify them adapting to their particular teaching context in accordance with a real open approach. At the current stage of the Edu-AREA development, a main issue is related to the management and classification of information provided by users. This paper introduces a folksonomy approach to tackle with this problem and analyses how to apply it in several elements of the Edu-AREA data model. In addition, a general view of the software architecture is provided.
DPQ: Using A Distributed Priority Queue to Improve Ad hoc TCP Performance

Network traffic can be broken into two categories: control packets (such as routing exploration/reply packets) and payload data packets. In a wireless ad hoc environment, it is generally accepted that control packets should be given higher priority for scheduling. In practice, it is also implemented this way within a single node. However, packets scheduling is not handled similarly from a distributed perspective. Control packets in one mobile node and data packets in another mobile node equally compete for the shared channel for future packet delivery. It is pointed out that under this policy, aggressiveness of TCP will hurt the successful delivery of control packets, which in turn will adversely impact TCP performance. In this paper, we propose and evaluate a partially ordered, distributed priority queue scheduling for the mobile ad hoc environment. Its performance is evaluated using network simulator ns2. The simulation results show that our mechanism can dramatically improve TCP performance by up to 20% in the ad hoc environment
Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection

Effective priming of T cell responses depends on cognate interactions between naive T cells and professional antigen-presenting cells (APCs). This contact is the result of highly coordinated migration processes, in which the chemokine receptor CCR7 and its ligands, CCL19 and CCL21, play a central role. We used the murine Listeria monocytogenes infection model to characterize the role of the CCR7/CCR7 ligand system in the generation of T cell responses during bacterial infection. We demonstrate that efficient priming of naive major histocompatibility complex (MHC) class Ia–restricted CD8+ T cells requires CCR7. In contrast, MHC class Ib–restricted CD8+ T cells and MHC class II–restricted CD4+ T cells seem to be less dependent on CCR7; memory T cell responses are independent of CCR7. Infection experiments with bone marrow chimeras or mice reconstituted with purified T cell populations indicate that CCR7 has to be expressed on CD8+ T cells and professional APCs to promote efficient MHC class Ia–restricted T cell priming. Thus, different T cell subtypes and maturation stages have discrete requirements for CCR7.
Response to Letter by Lenglinger et al.

TO THE EDITOR: We read with great interest a randomized controlled trial by Sotoudehmanesh et al. (1) titled “Indomethacin May Reduce the Incidence and Severity of Acute Pancreatitis After ERCP” that has been published in the recent issue of the Journal. The authors concluded that rectal indomethacin given right before endoscopic retrograde cholangiopancreatography (ERCP) can reduce the incidence and severity of post-ERCP pancreatitis (PEP). However, before incorporating this inexpensive, easily available nonsteroidal anti-inflammatory drug (NSAID) into our clinical practice for PEP prevention, several issues need further clarification: (a) It had been pointed out from a prospective large sample study that only individuals with serum amylase levels fivefold the normal upper limits and persistent pancreaticlike pain for 24 h after ERCP strongly suggest possibility of PEP (2); however, the authors stated that besides the 2-h measurement, serum amylase was repeated the next morning, and it is not clear what the exact time interval was. This may cast some doubt on the accuracy of the diagnosis of PEP in this study. (b) In the Methods section, the authors claimed subgroup analysis was used to evaluate the effect of indomethacin related to different variables. Notwithstanding, due to the lack of relevant information, it is not clear whether these subgroup analyses were ad hoc or post hoc. If these subgroup analyses were performed retrospectively, it should be considered as “fishing” for positive results, and the results from subgroup analyses should be treated with caution (3). (c) No explanation was provided as to why none of the sphincter of Oddi dysfunction (SOD) patients developed PEP, which is contrary to most other reported trials, with PEP incidence of up to 24% for patients with suspicious SOD (4). (d) They found that pancreatic duct injection, pancreatic duct cannulation more than once, and age less than 60 yr were significant risk factors for developing PEP. Certainly, it is convenient to perform a univariate analysis for exploration of each variable’s influence on the primary outcome; nonetheless, up to now, available evidence suggests that the incidence of PEP was not determined by any single factor. Thus, a multivariate statistical analysis with logistic regression allowing estimation of the influence of covariates on the incidence of PEP seems more appropriate. To summarize, this study suggests indomethacin may be an attractive pharmacotherapy for the prevention of PEP because it is inexpensive, universally available, and relatively safe. Clarification on some raised concerns will better our understanding of the mystery of PEP and its pharmacotherapy prevention. Yu Bai, M.D. Duowu Zou, M.D. Zhaoshen Li, M.D.
Comparison of Myelodysplastic Syndrome Prognostic Scoring Systems

Objective: Myelodysplastic syndrome (MDS) is a clonal hematopoietic stem cell disease. Patients are at risk of developing cytopenias or progression to acute myeloid leukemia. Different classifications and prognostic scoring systems have been developed. The aim of this study was to compare the different prognostic scoring systems. Materials and Methods: One hundred and one patients who were diagnosed with primary MDS in 2003-2011 in a tertiary care university hospital’s hematology department were included in the study. Results: As the International Prognostic Scoring System (IPSS), World Health Organization Classification-Based Prognostic Scoring System (WPSS), MD Anderson Prognostic Scoring System (MPSS), and revised IPSS (IPSS-R) risk categories increased, leukemia-free survival and overall survival decreased (p<0.001). When the IPSS, WPSS, MPSS, and IPSS-R prognostic systems were compared by Cox regression analysis, the WPSS was the best in predicting leukemia-free survival (p<0.001), and the WPSS (p<0.001) and IPSS-R (p=0.037) were better in predicting overall survival. Conclusion: All 4 prognostic systems were successful in predicting overall survival and leukemia-free survival (p<0.001). The WPSS was found to be the best predictor for leukemia-free survival, while the WPSS and IPSS-R were found to be the best predictors for overall survival.
Thyroid Antibodies and Miscarriage: Where Are We at a Generation Later?

In 1990, an association between thyroid antibody positivity and spontaneous miscarriage was first reported. A generation has passed since the initial observation. Over that time a robust literature has developed which has confirmed the initial finding and expanded upon it. The present paper reviews the literature that has been generated over the last twenty years on the following topics: (1) thyroid antibodies and spontaneous miscarriage, (2) thyroid antibodies and recurrent abortion, (3) etiology of pregnancy loss in thyroid antibody positive women, and (4) discussion of future research directions.
Online Learning of Multiple Tasks and Their Relationships

We propose an Online MultiTask Learning (Omtl) framework which simultaneously learns the task weight vectors as well as the task relatedness adaptively from the data. Our work is in contrast with prior work on online multitask learning which assumes fixed task relatedness, a priori. Furthermore, whereas prior work in such settings assume only positively correlated tasks, our framework can capture negative correlations as well. Our proposed framework learns the task relationship matrix by framing the objective function as a Bregman divergence minimization problem for positive definite matrices. Subsequently, we exploit this adaptively learned task-relationship matrix to select the most informative samples in an online multitask active learning setting. Experimental results on a number of real-world datasets and comparisons with numerous baselines establish the efficacy of our proposed approach.
Speaking about writing : reflections on research methodology

Introduction - Peter Smagorinsky Potential Problems and Problematic Potentials of Using Talk About Writing as Data About Writing Process PART ONE: THINK-ALOUD PROTOCOL ANALYSIS Think-Aloud Protocol Analysis - Peter Smagorinsky Beyond the Black Box Think-Aloud Protocols, Protocol Analysis, and Research Design - Stephen P Witte and Roger D Cherry An Exploration of the Influence of Writing Tasks on Writing Processes Substance and Romance in Analyzing Think-Aloud Protocols - Robert J Bracewell and Alain Breuleux Reactivity in Concurrent Think-Aloud Protocols - James F Stratman and Liz Hamp-Lyons Issues for Research PART TWO: RETROSPECTIVE ACCOUNTS OF WRITING PROCESS 'Once Upon a Time' - Stuart Greene and Lorraine Higgins The Use of Retrospective Accounts in Building Theory in Composition Using Intervention Protocols to Study the Effects of Instructional Scaffolding on Writing and Learning - Deborah Swanson-Owens and George E Newell Stimulated Recall in Research on Writing - Anne DiPardo An Antidote to 'I Don't Know, It Was Fine' PART THREE: ANALYSIS OF COLLABORATIVE DISCOURSE Interpreting and Counting - George Hillocks Jr Objectivity in Discourse Analysis Discourse Analysis of Teacher-Student Writing Conferences - Melanie Sperling Finding the Message in the Medium What's All This Talk I Hear? Using Sociolinguistic Analysis to Locate and Map Themes in Teacher/Student Talk About Writing - Elizabeth Hodges PART FOUR: INTERVIEWS IN THE FIELD Ethnographic Interviews and Writing Research - Elaine Chin A Critical Examination of the Methodology PART FIVE: COUNTERPOINT Whither Wisdom? - David N Dobrin Withered Wisdom - Robert J Bracewell A Reply to Dobrin