Miracle-dz/UniFAR-FTUs huggingface dataset:
Learning Analytics Dashboards for Advisors - A Systematic Literature Review

Learning Analytics Dashboard for Advisors is designed to provide data-driven insights and visualizations to support advisors in their decision-making regarding student academic progress, engagement, targeted support, and overall success. This study explores the current state of the art in learning analytics dashboards, focusing on specific requirements for advisors. By examining existing literature and case studies, this research investigates the key features and functionalities essential for an effective learning analytics dashboard tailored to advisor needs. This study also aims to provide a comprehensive understanding of the landscape of learning analytics dashboards for advisors, offering insights into the advancements, opportunities, and challenges in their development by synthesizing the current trends from a total of 21 research papers used for analysis. The findings will contribute to the design and implementation of new features in learning analytics dashboards that empower advisors to provide proactive and individualized support, ultimately fostering student retention and academic success.
Fish and tetrapod communities across a marine to brackish salinity gradient in the Pennsylvanian (early Moscovian) Minto Formation of New Brunswick, Canada, and their palaeoecological and palaeogeographical implications

Euryhaline adaptations in Pennsylvanian vertebrates allowed them to inhabit the marine to freshwater spectrum. This is illustrated by new assemblages of fish and tetrapods from the early Moscovian Minto Formation of New Brunswick, Canada. Fish include chondrichthyans (xenacanthids and the enigmatic Ageleodus), acanthodians (gyracanthids and acanthodiforms), sarcopterygians (rhizodontids, megalichthyids and dipnoans), and actinopterygians (eurynotiforms). Tetrapods include small‐ to medium‐sized, and largely aquatic, stem tetrapods (colosteids) and anthracosaurs (embolomeres). A key finding is that the parautochthonous fossil assemblages are preserved across a salinity gradient, with diversity (measured by the Simpson Index) declining from open marine environments, through brackish embayments, and reaching a nadir in tidal estuaries. Chondrichthyans dominate the entire salinity spectrum (65% of fossils), a distribution that demonstrates a euryhaline mode of life, and one large predatory chondrichthyan, Orthacanthus, may have practised filial cannibalism in coastal nurseries because its heteropolar coprolites contain juvenile xenacanthid teeth. In contrast, other fish communities were more common in open marine settings while tetrapods were more common in coastal brackish waters. While all these faunas were also likely to have been euryhaline, their osmoregulation was, perhaps, less versatile. The demonstration of widespread euryhalinity among fish and aquatic tetrapods explains why Pennsylvanian faunas generally show a cosmopolitan biogeography because taxa were able to disperse via seaways. It also resolves the paradox of enriched strontium isotopic signatures observed in these faunas because organisms would have been, at times, exposed to continental water bodies as well. Therefore, our new findings contribute to the long‐running debate about the ecology of Pennsylvanian fishes and tetrapods.
THE RELATIONSHIP OF SELF-EFFICACY WITH PERCEIVED FUTURE EMPLOYABILITY IN JOB SEEKERS OF HIGHER COLLEGE GRADUATES IN PADANG CITY

Over the last few years, unemployment in Indonesia has been dominated by the educated workforce. Unemployed people with the highest education completed at a university reached 673,485 people (Central Statistics Agency, 2022). College graduates who have job seeker status experience difficulty in obtaining employment. Therefore, college graduates need to be ready to enter the world of work. Perceived future employability refers to the perception of how employable he will be in the future and ready to enter the job market. The perception of self-readiness is preceded by a person's belief in his or her abilities. The aim of this research is to determine the relationship between self-efficacy and perceived future employability among job seekers who graduate from universities in Padang City. This research uses the theory of perceived future employability and self-efficacy. The sampling technique used in this research was purposive sampling. This research uses product moment correlation test data analysis techniques. It was found that the value of r = 0.631 with a value of p = 0.000 (p < 0.05) means that Ha was accepted, so it is known that there is a significant positive relationship between self-efficacy and perceived future employability in job seekers who graduated from universities in the city of Padang.
The depositional environment of surging sub-polar tidewater glaciers : a case study of the morphology, sedimentation and sediment properties in a surge affected marine basin outside Nordaustlandet, Northern Barents Sea

The present study addresses the importance of glacier surges in the marine environment. Glacier surges are common in Svalbard, as well as in other Arctic and sub-Arctic regions, and the surging of tidewater glaciers may have been an important process during past glaciations when extensive continental shelf areas were covered by grounded ice. An area outside Austfonna ice cap, Nordaustlandet, Svalbard, has been extensively studied by means of shallow seismic profiling, side-scan sonar, and core sampling over a period of several years. Important aspects of the shallow geology discussed include sea floor morphology, sediment distribution and sediment types, sediment physical properties and sedimentation processes and rates
Variation in magnetic properties of serpentinized peridotites exposed on the Yokoniwa Rise, Central Indian Ridge: Insights into the role of magnetite in serpentinization

Magnetic properties in serpentinized peridotites are of increasing interest in seafloor mapping and petrologic studies because such data can promote the understanding of serpentinization reactions and hydrogen creation in ultramafic rocks. In order to reveal the magnetic properties and magnetite growth in serpentinized peridotites, we analyzed 30 serpentinized peridotite samples from a nontransform offset massif called the Yokoniwa Rise in the Central Indian Ridge. The results from multiple rock magnetic analyses and petrological observations illustrate the details of the creation and growth of magnetite in serpentinized peridotites that have undergone 17–100% serpentinzation. The magnetic carrier of these samples is pure magnetite, which did not suffer from maghemitization (low‐temperature oxidation). The magnetic susceptibility ranged from 0.002 to 0.087 SI and increased nonlinearly with the progression of the serpentinization reaction. The natural remanent magnetization intensities of 0.2–8.4 A/m are comparable to those of basalts, which suggests that the remanence as well as induced magnetization of highly serpentinized peridotite can contribute to magnetization of the oceanic lithosphere. The amount of magnetite estimated from saturation magnetization increased nonlinearly from 0.1 to 5.5 wt % with the progression of the serpentinization. Highly serpentinized peridotites have a well‐developed serpentine mesh texture. Pseudo‐single‐domain (PSD) and multidomain (MD) grains were formed during igneous processes in the mantle and/or during the initial stages of serpentinization. Superparamagnetic (SP) particles were formed during the initial stages of serpentinization. Single‐domain (SD) magnetite was formed during the later stage of serpentinization, and it is assembled inside of mesh structures with strong magnetostatic interactions.
Mitral valve prolapse syndrome

Mitral valve prolapse is a common valvular defect. In its overt clinical form, the condition known as mitral valve leaflet prolapse syndrome, or also known as Barlow's syndrome or flaccid valve syndrome, is a significant clinical problem, worsening the quality of life of patients, and in its severe forms is a risk factor for diseases such as congestive heart failure, endocarditis or cardiac arrhythmias, or even lead to death from sudden cardiac death. The development of methods, as well as the increasing general availability of echocardiography methods, makes a specific diagnosis early enough to allow the right treatment strategy to be chosen. Thanks to reliable reports in recent years, it has been possible to identify a group of patients whose cardiovascular risk predisposes them to a more severe course of the disease and thus these patients require special observation and attention in the process of diagnosis and treatment. Recent years have allowed the development of a new method of interventional treatment in patients burdened with multimorbidity for whom conventional surgery would be associated with a significant risk of worsening of the general condition.
PWAS Hub: Exploring Gene-Based Associations of Common Complex Diseases

PWAS (Proteome-Wide Association Study) is an innovative genetic association approach that complements widely-used methods like GWAS (Genome-Wide Association Study). The PWAS platform involves consecutive phases. Initially, machine learning modeling and probabilistic considerations quantified the impact of genetic variants on protein-coding genes' biochemical functions. Secondly, aggregating the variants per gene for each individual determines a gene-damaging score. Finally, standard statistical tests are activated in the case-control setting to yield statistically significant genes per phenotype. The PWAS Hub offers a user-friendly interface for an in-depth exploration of gene-disease associations from the UK Biobank (UKB). Results from PWAS cover 99 common diseases and conditions, each with over 10,000 diagnosed individuals per phenotype. Users can explore genes associated with these diseases, with separate analyses conducted for males and females. The PWAS Hub lists statistically significant genes associated with common diseases. It also indicates whether the analyzed damaged gene is associated with an increased or decreased risk. For each phenotype, the analyses account for sex-based genetic effects, inheritance modes (dominant and recessive), and the pleiotropic nature of associated genes. The PWAS Hub showcases its usefulness by navigating through such proteomic-genetic application for asthma. Graphical tools facilitate comparing genetic effects between the results of PWAS and coding GWAS, aiding in understanding the sex-specific genetic impact on common diseases. This adaptable platform is attractive for clinicians, researchers, and individuals interested in delving into gene-disease associations and sex-specific genetic effects. The PWAS Hub is accessible at http://pwas.huji. ac.il.
Stability and Volatility of Human Rest-Activity Rhythms: Insights from Very Long Actograms (VLAs)

Importance: Wrist-worn activity monitors provide biomarkers of health by non-obtrusively measuring the timing and amount of rest and physical activity (rest-activity rhythms, RARs). The morphology and robustness of RARs vary by age, gender, and sociodemographic factors, and are perturbed in various chronic illnesses. However, these are cross-sectionally derived associations from recordings lasting 4-10 days, providing little insights into how RARs vary with time. Objective: To describe how RAR parameters can vary or evolve with time (~months). Design, Setting and Participants: 48 very long actograms ('VLAs', >90 days in duration) were identified from subjects enrolled in the STAGES (Stanford Technology, Analytics and Genomics in Sleep) study, a prospective cross-sectional, multi-site assessment of individuals > 13 years of age that required diagnostic polysomnography to address a sleep complaint. A single 3-year long VLA (author GD) is also described. Exposures/Intervention: None planned. Main Outcomes and Measures: For each VLA, we assessed the following parameters in 14-day windows: circadian/ultradian spectrum, pseudo-F statistic ('F'), cosinor amplitude, intradaily variability, interdaily stability, acrophase and estimates of 'sleep' and non-wearing. Results: Included STAGES subjects (n = 48, 30 female) had a median age of 51, BMI of 29.4kg/m2, Epworth Sleepiness Scale score (ESS) of 10/24 and a median recording duration of 120 days. We observed marked within-subject undulations in all six RAR parameters, with many subjects displaying ultradian rhythms of activity that waxed and waned in intensity. When appraised as a cohort, averaged RAR parameters remained remarkably stable over a ~4 month recording period. Deficits in average RAR robustness associated with unemployment or high BMI (>29.4) also remained stable over time. Conclusions and Relevance: Through an exemplary set of months-long wrist actigraphy recordings, this study quantitatively depicts the longitudinal stability and dynamic range of human rest-activity rhythms. We propose that actigraphy may have broad potential as a holistic, transdiagnostic and ecologically valid monitoring biomarker of chronobiological health. Prospective recordings from willing subjects will be necessary to precisely define contexts of use.
Exploring DNA Damage and Repair Mechanisms: A Review with Computational Insights

DNA damage is a critical factor contributing to genetic alterations, directly affecting human health, including developing diseases such as cancer and age-related disorders. DNA repair mechanisms play a pivotal role in safeguarding genetic integrity and preventing the onset of these ailments. Over the past decade, substantial progress and pivotal discoveries have been achieved in DNA damage and repair. This comprehensive review paper consolidates research efforts, focusing on DNA repair mechanisms, computational research methods, and associated databases. Our work is a valuable resource for scientists and researchers engaged in computational DNA research, offering the latest insights into DNA-related proteins, diseases, and cutting-edge methodologies. The review addresses key questions, including the major types of DNA damage, common DNA repair mechanisms, the availability of reliable databases for DNA damage and associated diseases, and the predominant computational research methods for enzymes involved in DNA damage and repair.
Comparison of 68Ga-DOTATATE Positron Emmited Tomography/Computed Tomography and Gadoxetic Acid-Enhanced Magnetic Resonance Imaging for the Detection of Liver Metastases from Well-Differentiated Neuroendocrine Tumors

This study aimed to compare the detection of neuroendocrine tumor liver metastases (NLMs) in hepatobiliary-specific contrast-enhanced MRI (pMR) versus 68Ga-DOTATATE PET/CT (DT-PET). This retrospective study cohort included 30 patients with well-differentiated neuroendocrine tumors who underwent both DT-PET and pMR. Two readers independently assessed NLMs count, SUVmax on DT-PET, and signal characteristics on pMR. A consensus review by two additional readers resolved discrepancies between the modalities. Results showed concordance between DT-PET and pMR NLM count in 14/30 patients (47%). pMR identified more NLMs in 12/30 patients (40%), of which 4 patients showed multiple deposits on pMR but only 0–1 lesions on DT-PET. DT-PET detected more in 4/30 patients (13%). Overall, pMR detected more metastases than DT-PET (p = 0.01). Excluding the four outliers, there was excellent agreement between the two methods (ICC: 0.945, 95%CI: 0.930, 0.958). Notably, pMR had a higher NLM detection rate than DT-PET, with correlations found between lesion size on pMR and DT-PET detectability, as well as diffusion restriction on pMR and SUVmax on DT-PET. In conclusion, in consecutive patients with well-differentiated NETs, the detection rate of NLM is higher with pMR than with DT-PET. However, when excluding patients whose tumors do not overexpress somatostatin receptors (13% of the cohort), high concordance in the detection of NLM is observed between DT PET and pMR.
Integrated remote sensing and GIS-based approach for mapping the groundwater potential in Kota Kinabalu, Sabah, Malaysia

Demand for groundwater resources is increasing from time to time due to the insufficient surface water supply to meet the growing demand. The increasing demand for water resources is caused by many factors such as population increase, urbanization and farming activities. Therefore the study to determine groundwater availability is quiet difficult due to the existence of multiple contributing factors. This study was conducted based on the parameters that contribute to the availability of groundwater potential. There are nine parameters used in this study i.e. lineament, land-use, rainfall, lithology, topography, slope, drainage, soil types and the ratio of sand and clay. These parameters are collected, processed, analyzed, integrated and modeled by using the remote sensing and Geographic Information Systems (GIS) techniques to create all the related thematic maps. Two software that have been used in this study are ERDAS IMAGINE 8.4 and ILWIS 3.3. The different ranks and weightages were assigned to respective different parameters with reference to groundwater and generated individual layers. Then, all the individual thematic layers were integrated; the weightages of each parameter added and finally the area has been divided into different groundwater potential zones using the Index Overlay and Analytical Hierarchy Process (AHP) method. The potential map was further classified into five categories or zones namely very high, high, moderate, low and very low.
Acceptability and Feasibility of a Smartphone-Based Real-Time Assessment of Suicide Among Black Men: Mixed Methods Pilot Study

Background Suicide rates in the United States have increased recently among Black men. To address this public health crisis, smartphone-based ecological momentary assessment (EMA) platforms are a promising way to collect dynamic, real-time data that can help improve suicide prevention efforts. Despite the promise of this methodology, little is known about its suitability in detecting experiences related to suicidal thoughts and behavior (STB) among Black men. Objective This study aims to clarify the acceptability and feasibility of using smartphone-based EMA through a pilot study that assesses the user experience among Black men. Methods We recruited Black men aged 18 years and older using the MyChart patient portal messaging (the patient-facing side of the Epic electronic medical record system) or outpatient provider referrals. Eligible participants self-identified as Black men with a previous history of STB and ownership of an Android or iOS smartphone. Eligible participants completed a 7-day smartphone-based EMA study. They received a prompt 4 times per day to complete a brief survey detailing their STB, as well as proximal risk factors, such as depression, social isolation, and feeling like a burden to others. At the conclusion of each day, participants also received a daily diary survey detailing their sleep quality and their daily experiences of everyday discrimination. Participants completed a semistructured exit interview of 60-90 minutes at the study’s conclusion. Results In total, 10 participants completed 166 EMA surveys and 39 daily diary entries. A total of 4 of the 10 participants completed 75% (21/28) or more of the EMA surveys, while 9 (90%) out of 10 completed 25% (7/28) or more. The average completion rate of all surveys was 58% (20.3/35), with a minimum of 17% (6/35) and maximum of 100% (35/35). A total of 4 (40%) out of 10 participants completed daily diary entries for the full pilot study. No safety-related incidents were reported. On average, participants took 2.08 minutes to complete EMA prompts and 2.72 minutes for daily diary surveys. Our qualitative results generally affirm the acceptability and feasibility of the study procedures, but the participants noted difficulties with the technology and the redundancy of the survey questions. Emerging themes also addressed issues such as reduced EMA survey compliance and diminished mood related to deficit-framed questions related to suicide. Conclusions Findings from this study will be used to clarify the suitability of EMA for Black men. Overall, our EMA pilot study demonstrated mixed feasibility and acceptability when delivered through smartphone-based apps to Black men. Specific recommendations are provided for managing safety within these study designs and for refinements in future intervention and implementation science research. International Registered Report Identifier (IRRID) RR2-10.2196/31241
The Inhibition of the Membrane-Bound Transcription Factor Site-1 Protease (MBTP1) Alleviates the p.Phe508del-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Defects in Cystic Fibrosis Cells

Cystic Fibrosis (CF) is present due to mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene, the most frequent variant being p.phe508del. The CFTR protein is a chloride (Cl-) channel which is defective and almost absent of cell membranes when the p.Phe508del mutation is present. The p.Phe508del-CFTR protein is retained in the endoplasmic reticulum (ER) and together with inflammation and infection triggers the Unfolded Protein Response (UPR). During the UPR, the Activating Transcription Factor 6 (ATF6) is activated with cleavage and then decreases the expression of p.Phe508del-CFTR. We have previously shown that the inhibition of the activation of ATF6 alleviates the p.Phe508del-CFTR defects in cells overexpressing the mutated protein. In the present paper, our aim was to inhibit the cleavage of ATF6, and thus its activation in a human bronchial cell line with endogenous p.Phe508del-CFTR expression and in bronchial cells from patients, to be more relevant to CF. This was achieved by inhibiting the protease MBTP1 which is responsible for the cleavage of ATF6. We show here that this inhibition leads to increased mRNA and p.Phe508del-CFTR expression and, consequently, to increased Cl-efflux. We also explain the mechanisms linked to these increases with the modulation of genes when MBTP1 is inhibited. Indeed, RT-qPCR assays show that genes such as HSPA1B, CEBPB, VIMP, PFND2, MAPK8, XBP1, INSIG1, and CALR are modulated. In conclusion, we show that the inhibition of MBTP1 has a beneficial effect in relevant models to CF and that this is due to the modulation of genes involved in the disease.