Miracle-dz/UniFAR-FTUs huggingface dataset:
Bisphosphonate‐Associated Osteonecrosis of the Jaw: Report of a Task Force of the American Society for Bone and Mineral Research

ONJ has been increasingly suspected to be a potential complication of bisphosphonate therapy in recent years. Thus, the ASBMR leadership appointed a multidisciplinary task force to address key questions related to case definition, epidemiology, risk factors, diagnostic imaging, clinical management, and future areas for research related to the disorder. This report summarizes the findings and recommendations of the task force.
Cached SLM to reduce the PAPR of OFDM signal

Selected mapping (SLM) is one of the most well‐known peak‐to‐average power ratio (PAPR) reduction techniques proposed for the orthogonal frequency‐division multiplexing (OFDM) systems. The main drawback of the conventional SLM scheme is high computational complexity because of numerous inverse fast fourier transform (IFFT) operations when transmitting one OFDM signal, which may hinder its wide application in certain systems. The aim of this paper is to propose a post‐IFFT PAPR reduction scheme based on a cache structure. in the proposed scheme, several candidates are created through combining two of time‐domain signal vectors in cache and the one with the lowest PAPR is transmitted. Because the generation of candidates is implemented after the IFFT, one OFDM signal only requires one complex IFFT operation when using the proposed cache scheme. simulation results show that the new proposed scheme has promising PAPR performance while it decreases the complexity compared with the conventional SLM scheme. In addition, the cache scheme has the ability to be combined with other scheme such as SLM to further reduce the PAPR at the cost of a moderate increase of the complexity. Copyright © 2012 John Wiley & Sons, Ltd.
City Under Siege: Narrating Mumbai Through NonStop Capture

When Mumbai became the target of terror in the 26/11 attack in 2008, the events in that city, like other tragic global events in recent years, were narrated through new media platforms. The increasing convergence of technologies and mobile telephony enabled new forms of gaze and the ability to bear witness through these new media technologies. The non-stop capture of events through recording equipment embedded in mobile phones and their connectivity to the World Wide Web constructed Mumbai through civilian narratives and images, and this phenomenon was described as the ”coming of age of Twitter”. Conversely the event raised fundamental questions about the role of broadcasting and protocols in live telecasts of terrorist attacks which have consequences for national security. In narrating the city through the civilian gaze and traditional media the spectacle of suffering in postmodernity becomes an open-ended exercise where the city is both a canvas for showcasing the risks of modernity and new forms of visibilities which emerge from social media and the ”act of sharing” content on global platforms.
Belief propagation based localization and mapping using sparsely sampled GNSS SNR measurements

A novel approach is proposed to achieve simultaneous localization and mapping (SLAM) based on the signal-to-noise ratio (SNR) of global navigation satellite system (GNSS) signals. It is assumed that the environment is unknown and that the receiver location measurements (provided by a GNSS receiver) are noisy. The 3D environment map is decomposed into a grid of binary-state cells (occupancy grid) and the receiver locations are approximated by sets of particles. Using a large number of sparsely sampled GNSS SNR measurements and receiver/satellite coordinates (all available from off-the-shelf GNSS receivers), likelihoods of blockage are associated with every receiver-to-satellite beam. The posterior distribution of the map and poses is shown to represent a factor graph, on which Loopy Belief Propagation is used to efficiently estimate the probabilities of each cell being occupied or empty, along with the probability of the particles for each receiver location. Experimental results demonstrate our algorithm's ability to coarsely map (in three dimensions) a corner of a university campus, while also correcting for uncertainties in the location of the GNSS receiver.
In silico mining of EST databases for novel pre‐implantation embryo‐specific zinc finger protein genes *

Progress in the understanding of early mammalian embryo development has been severely hampered by scarcity of study materials. To circumvent such a constraint, we have developed a strategy that involves a combination of in silico mining of new genes from expressed sequence tags (EST) databases and rapid determination of expression profiles of the dbEST‐derived genes using a PCR‐based assay and a panel of cDNA libraries derived from different developmental stages and somatic tissues. We demonstrate that in a random sample of 49 independent dbEST‐derived zinc finger protein genes mined from a mouse embryonic 2‐cell cDNA library, more than three‐quarters of these genes are novel. Examination of characteristics of the human orthologues derived from these mouse genes reveals that many of them are associated with human malignancies. Expression studies have further led to the identification of three novel genes that are exclusively expressed in mouse embryos before or up to the 8‐cell stage. Two of the genes, designated 2czf45 and 2czf48 (2czf for 2‐cell zinc finger), are zinc finger protein genes coding for a RBCC protein with a RFP domain and a protein with three C2H2 fingers, respectively. The third gene, designated 2cpoz56, codes for a protein with a POZ domain that is often associated with zinc finger proteins. These three genes are candidate genes for regulatory or other functions in early embryogenesis. The strategy described in this report should generally be applicable to rapid and large‐scale mining of other classes of rare genes involved in other biological and pathological processes. Mol. Reprod. Dev. 59:249–255, 2001. © 2001 Wiley‐Liss, Inc.
Diagnosis and management of carotid atherosclerosis

#### Summary points #### Sources and selection criteria We search PubMed using the keywords “carotid AND athero* OR stenosis OR plaque”. Key randomised controlled trials and cohort studies were identified. We searched the Cochrane Library using the keyword “carotid”. The UK fourth national clinical guideline for stroke 2012, UK carotid endarterectomy audit round 4, European Society for Vascular Surgery carotid guidelines parts A-C, and European Society for Cardiology fifth guideline on cardiovascular disease prevention were consulted, along with relevant references from these articles. Carotid atherosclerosis is a pathological thickening of the common or internal carotid intima, typically into focal areas known as plaques (or atheromata). Although atheromata can remain stable for many years, surface rupture of unstable (vulnerable) plaques leads to local thrombus formation, with subsequent embolisation to the ipsilateral ophthalmic, middle cerebral, or anterior cerebral artery territories. The resultant symptoms are ipsilateral amaurosis fugax or retinal infarction and contralateral body transient ischaemic attack (TIA) or stroke. This review discusses the risk factors, clinical presentation, investigations, and treatment options for symptomatic and asymptomatic carotid atherosclerosis. All references to stenosis use consensus North American Symptomatic Carotid Endarterectomy Trial (NASCET) measurements.1 All recommendations reflect current UK guidelines, unless stated otherwise. Moderate to severe asymptomatic carotid atherosclerotic stenosis is found in 2-5% …
What is the evidence that postgraduate teaching in evidence based medicine changes anything? A systematic review

Abstract Objective To evaluate the effects of standalone versus clinically integrated teaching in evidence based medicine on various outcomes in postgraduates. Design Systematic review of randomised and non-randomised controlled trials and before and after comparison studies. Data sources Medline, Embase, ERIC, Cochrane Library, DARE, HTA database, Best Evidence, BEME, and SCI. Study selection 23 studies: four randomised trials, seven non-randomised controlled studies, and 12 before and after comparison studies. 18 studies (including two randomised trials) evaluated a standalone teaching method, and five studies (including two randomised trials) evaluated a clinically integrated teaching method. Main outcome measures Knowledge, critical appraisal skills, attitudes, and behaviour. Results Standalone teaching improved knowledge but not skills, attitudes, or behaviour. Clinically integrated teaching improved knowledge, skills, attitudes, and behaviour. Conclusion Teaching of evidence based medicine should be moved from classrooms to clinical practice to achieve improvements in substantial outcomes.
Escitalopram 10 mg/day is effective and well tolerated in a placebo-controlled study in depression in primary care

Escitalopram, a selective serotonin reuptake inhibitor (SSRI), was compared to placebo in a study of patients with major depressive disorder (DSM-IV) who had baseline Montgomery–Åsberg Depression Rating Scale (MADRS) total scores ≥22 and ≤40. After a 1-week, single-blind placebo period, patients were randomized to receive escitalopram 10 mg/day (n =191) or placebo (n =189) in an 8-week, double-blind period. The primary efficacy analysis of adjusted mean change in MADRS total score from baseline showed a statistically significantly larger effect for escitalopram than for placebo with a treatment difference at week 8 (last observation carried forward, LOCF) of 2.7 points (SE 0.85;P =0.002). In further by-week efficacy analyses, the effect of escitalopram was consistently larger than that of placebo (P <0.05) beginning at week 1 (Clinical Global Impression–Improvement score), week 2 (MADRS score) or week 3 (Clinical Global Impression–Severity score). Escitalopram was very well tolerated with a low overall withdrawal rate similar to that for placebo. Nausea was the only adverse event reported significantly more in escitalopram-treated patients than in placebo-treated patients, although it was infrequent and transient. Escitalopram 10 mg/day had a statistically significantly better antidepressant effect than placebo as early as week 1, and was safe and very well tolerated.
A 10-bit 1GS/s 4-way TI SAR ADC with tap-interpolated FIR filter based time skew calibration

This paper presents a 10-bit 1GS/s 4-way time-interleaved (TI) successive approximation register (SAR) analog-to-digital converter (ADC). To reduce the time skew among the TI channels, the master clock based sampling technique is adopted that can effectively suppress the interleaving spurs to −54dB at Nyquist input. Morever, a tap-interpolating fractional delay (TIFD) filters based time skew calibration technique is proposed, which operates at background and can further reduce the interleaving spurs to be less than −70dB. The prototype was fabricated in a 65nm CMOS technology. The measurement results show that the ADC operating at 1GS/s achieves a SNDR of 49.6dB and SFDR of 61.6dB at Nyquist input resulting in a figure of merit (FoM) of 32fJ/conversion-step.
On constrained stochastic controllability of dynamical systems with multiple delays in control

Linear, continuous stochastic dynamical systems with multiple delays in control are studied in the paper. Their relative stochastic controllability with constrained control is discussed. The definitions of various type of constrained relative and absolute stochastic controllability for linear systems with delays in control are introduced. Criteria of relative and absolute stochastic controllability with constrained control are established. Constraints on control values are considered. Mutual implications between constrained relative stochastic controllability of systems with and without delays are studied as well as implications between constrained relative and absolute stochastic controllability of systems with delay in control.
A common trafficking route for GLUT4 in cardiomyocytes in response to insulin, contraction and energy-status signalling

A new mouse model has been developed to study the localisation and trafficking of the glucose transporter GLUT4 in muscle. The mouse line has specific expression of a GFP and HA-epitope-tagged version of GLUT4 under the control of a muscle-specific promoter. The exofacial HA-tag has enabled fluorescent labelling of only the GLUT4 exposed at the external surface. A distinction between sarcolemma labelling and transverse-tubule labelling has also been possible because the former compartment is much more accessible to intact anti-HA antibody. By contrast, the Fab fragment of the anti-HA antibody could readily detect GLUT4 at the surface of both the sarcolemma and transverse tubules. Here, we have used this mouse model to examine the route taken by cardiomyocyte GLUT4 as it moves to the limiting external membrane surface of sarcolemma and transverse-tubules in response to insulin, contraction or activators of energy-status signalling, including hypoxia. HA-GLUT4-GFP is largely excluded from the sarcolemma and transverse-tubule membrane of cardiomyocytes under basal conditions, but is similarly trafficked to these membrane surfaces after stimulation with insulin, contraction or hypoxia. Internalisation of sarcolemma GLUT4 has been investigated by pulse-labelling surface GLUT4 with intact anti-HA antibody. At early stages of internalisation, HA-tagged GLUT4 colocalises with clathrin at puncta at the sarcolemma, indicating that in cells returning to a basal state, GLUT4 is removed from external membranes by a clathrin-mediated route. We also observed colocalisation of GLUT4 with clathrin under basal conditions. At later stages of internalisation and at steady state, anti-HA antibody labeled-GLUT4 originating from the sarcolemma was predominantly detected in a peri-nuclear compartment, indistinguishable among the specific initial stimuli. These results taken together imply a common pathway for internalisation of GLUT4, independent of the initial stimulus.
Determinants of apparent rural-urban differentials in measles vaccination uptake in Indonesia.

INTRODUCTION Regional differences in vaccination uptake are common in both developed and developing countries, and are often linked to the availability of healthcare services and socioeconomic factors. In 2007, 0.9 million eligible Indonesian children missed measles vaccination, and 19 456 cases of measles were documented among Indonesian children. The authors investigated rural-urban differentials in measles vaccination coverage among young Indonesian children, and sought to identify key factors influencing the probability of a child receiving the first dose of measles vaccination in Indonesia. METHODS Data used in the analyses were sourced from the nationally representative Indonesia Demographic and Health Survey 2007. The influence of location of residence, household wealth, maternal and paternal education, total children ever born and use of skilled birth attendants on measles vaccination coverage was investigated using bivariate analysis and chi-square tests. The independent effects of these variables were established using binomial logistic regression analysis. RESULTS Indonesia's 2007 first-dose measles national vaccination coverage was, at 72.8%, lower than the 2008 global first-dose measles vaccination average coverage of 82%. Bivariate analysis revealed that the first-dose measles vaccination coverage in rural areas of Indonesia was 68.5%, compared with 80.1% in urban regions (p < 0.001). The apparent significance of rural residence in impairing vaccination coverage was marginal after controlling for the sex of the child, maternal age, maternal and paternal education, wealth, and access to skilled health workers. CONCLUSION Apart from sustainable initiatives to increase measles vaccination coverage globally, it is important to close the rural-urban gap in Indonesia's measles vaccination uptake. Addressing critical determinants of inferior measles vaccination coverage in Indonesia's rural regions will facilitate major improvements in Indonesia's child health trends. This article suggests initiatives for addressing three of such determinants in Indonesia's rural areas: poverty, parental education and access to skilled health workers.
Does VEGF have an effect on the survival of a long random skin flap by its application at the recipient area?

BACKGROUND Vascular endothelial growth factor (VEGF) is a hormone-like molecule which has been shown to act on a specific receptor system and in this way to be the basic regulator of angiogenesis. The effect on the survival of a long random skin flap was examined by exogenous administration of this cytokine, at flap's recipient site. MATERIALS & METHODS A standard dorsal skin flap measuring 1.5 x 7.5cm was elevated in eighteen wistar rats with the pedicle centered and attached between the lower angles of the scapulae. The length to width ratio was relatively high (5:1). The rats were divided in two groups of nine. In group A, flap was elevated and a skin defect was created next to it. Normal saline was injected into the fascia of the defect and the flap was transposed and secured over the previously created recipient site. In group B, flap was elevated and transposed to a previous created defect, as before, where, this time, injections of VEGF were applied into the fascia of the recipient bed. Seven days later the rats were euthanized and the flaps were excised. The underlying fascias of the recipient beds were also excised in the same dimensions. The specimens were measured, photographed and put into formalin 10%. Immunohistochemical staining and histological analysis followed. RESULTS The differentiation between the surviving and the necrotic skin was macroscopically clear within seven days time. In group A, the mean flap survival percentage was 36.8%. In group B the percentage was 56.3%, respectively. Neovascularization of the fascia of the recipient bed was also demonstrated when VEGF had been injected. CONCLUSIONS Exogenous administration of VEGF into the recipient bed of a skin flap improved the survival rate even though the flap's length was relatively high compared to its width.
Evidence for Two Numerical Systems That Are Similar in Humans and Guppies

Background Humans and non-human animals share an approximate non-verbal system for representing and comparing numerosities that has no upper limit and for which accuracy is dependent on the numerical ratio. Current evidence indicates that the mechanism for keeping track of individual objects can also be used for numerical purposes; if so, its accuracy will be independent of numerical ratio, but its capacity is limited to the number of items that can be tracked, about four. There is, however, growing controversy as to whether two separate number systems are present in other vertebrate species. Methodology/Principal Findings In this study, we compared the ability of undergraduate students and guppies to discriminate the same numerical ratios, both within and beyond the small number range. In both students and fish the performance was ratio-independent for the numbers 1–4, while it steadily increased with numerical distance when larger numbers were presented. Conclusions/Significance Our results suggest that two distinct systems underlie quantity discrimination in both humans and fish, implying that the building blocks of uniquely human mathematical abilities may be evolutionarily ancient, dating back to before the divergence of bony fish and tetrapod lineages.
DuraCache: A durable SSD cache using MLC NAND flash

Adopting SSDs as caches for HDD arrays has gained popularity in datacenters because SSDs are superior in handling random reads that HDDs cannot efficiently deal with. Two types of flash memory cells are available for building SSD caches, single-level cells (SLC) and multi-level cells (MLC). MLC is more appealing than SLC because it can achieve higher cache capacity at the same cost. However, we see a critical issue for SSD caches to adopt MLC NAND flash: the endurance of modern MLC NAND flash is too low to sustain datacenter workloads. In this paper, we propose DuraCache that addresses the durability issue of SSD caches. DuraCache exploits the fact that SSD caches are write-through caches in datacenters. Therefore, uncorrectable errors in SSD caches can be handled like cache misses which bring in correct data from HDD arrays. In addition, DuraCache gradually allocates more ECC parities associated with data when NAND flash reaches wearout thresholds. This allows SSD caches to continue operating by sacrificing available capacity. We conduct empirical experiments and demonstrate that DuraCache enables MLC SSD caches to achieve 4.1 years of service life assuming a TPC-C workload.
Relationships between authors of clinical practice guidelines and the pharmaceutical industry.

CONTEXT Increasing contact has been reported between physicians and the pharmaceutical industry, although no data exist in the literature regarding potential financial conflicts of interest for authors of clinical practice guidelines (CPGs). These interactions may be particularly relevant since CPGs are designed to influence the practice of a large number of physicians. OBJECTIVE To quantify the extent and nature of interactions between authors of CPGs and the pharmaceutical industry. DESIGN, SETTING, AND PARTICIPANTS Cross-sectional survey of 192 authors of 44 CPGs endorsed by North American and European societies on common adult diseases published between 1991 and July 1999. One hundred authors (52%) provided usable responses representing 37 of 44 different CPGs that we identified. MAIN OUTCOME MEASURES Nature and extent of interactions of authors with drug manufacturers; disclosure of relationships in published guidelines; prior discussion among authors regarding relationships; beliefs regarding whether authors' own relationships or those of their colleagues influenced treatment recommendations in guidelines. RESULTS Eighty-seven percent of authors had some form of interaction with the pharmaceutical industry. Fifty-eight percent had received financial support to perform research and 38% had served as employees or consultants for a pharmaceutical company. On average, CPG authors interacted with 10.5 different companies. Overall, an average of 81% (95% confidence interval, 70%-92%) of authors per CPG had interactions. Similarly, all of the CPGs for 7 of the 10 diseases included in our study had at least 1 author who had some interaction. Fifty-nine percent had relationships with companies whose drugs were considered in the guideline they authored, and of these authors, 96% had relationships that predated the guideline creation process. Fifty-five percent of respondents indicated that the guideline process with which they were involved had no formal process for declaring these relationships. In published versions of the CPGs, specific declarations regarding the personal financial interactions of individual authors with the pharmaceutical industry were made in only 2 cases. Seven percent thought that their own relationships with the pharmaceutical industry influenced the recommendations and 19% thought that their coauthors' recommendations were influenced by their relationships. CONCLUSIONS Although the response rate for this survey was low, there appears to be considerable interaction between CPG authors and the pharmaceutical industry. Our study highlights the need for appropriate disclosure of financial conflicts of interest for authors of CPGs and a formal process for discussing these conflicts prior to CPG development.