Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of Electron Illumination on the Image Resolution and Sensitivity of Catalysts Immersed in Gas Environments

Progress in gas cell technology has made transmission electron microscopy (TEM) capable of imaging heterogeneous catalysts in situ during exposure to reactive gas environments [1]. While these instrumental advances have opened up for impressive TEM studies of catalyst dynamics at the atomicscale, it has also become evident that the electron beam can substantially alter the catalyst and gas phase and, in turn, the chemical processes under inspection. It therefore becomes crucial to address the impact of electron illumination on in situ TEM observations and to suppress the electron-induced alterations to enable chemical relevant observations [2-4].
Nanoporous Quasi-High-Entropy Alloy Microspheres

High-entropy alloys (HEAs) present excellent mechanical properties. However, the exploitation of chemical properties of HEAs is far less than that of mechanical properties, which is mainly limited by the low specific surface area of HEAs synthesized by traditional methods. Thus, it is vital to develop new routes to fabricate HEAs with novel three-dimensional structures and a high specific surface area. Herein, we develop a facile approach to fabricate nanoporous noble metal quasi-HEA microspheres by melt-spinning and dealloying. The as-obtained nanoporous Cu30Au23Pt22Pd25 quasi-HEA microspheres present a hierarchical porous structure with a high specific surface area of 69.5 m2/g and a multiphase approximatively componential solid solution characteristic with a broad single-group face-centered cubic XRD pattern, which is different from the traditional single-phase or two-phase solid solution HEAs. To differentiate, these are named quasi-HEAs. The synthetic strategy proposed in this paper opens the door for the synthesis of porous quasi-HEAs related materials, and is expected to promote further applications of quasi-HEAs in various chemical fields.
Using secure coprocessors for privacy preserving collaborative data mining and analysis

Secure coprocessors have traditionally been used as a keystone of a security subsystem, eliminating the need to protect the rest of the subsystem with physical security measures. With technological advances and hardware miniaturization they have become increasingly powerful. This opens up the possibility of using them for non traditional use. This paper describes a solution for privacy preserving data sharing and mining using cryptographically secure but resource limited coprocessors. It uses memory light data mining methodologies along with a light weight database engine with federation capability, running on a coprocessor. The data to be shared resides with the enterprises that want to collaborate. This system will allow multiple enterprises, which are generally not allowed to share data, to do so solely for the purpose of detecting particular types of anomalies and for generating alerts. We also present results from experiments which demonstrate the value of such collaborations.
Independent Dominating Sets and a Second Hamiltonian Cycle in Regular Graphs

In 1975, John Sheehan conjectured that every Hamiltonian 4-regular graph has a second Hamiltonian cycle. Combined with earlier results this would imply that every Hamiltonianr-regular graph (r? 3) has a second Hamiltonian cycle. We shall verify this forr? 300.
Automatic formal verification of fused-multiply-add FPUs

In this paper we describe a fully-automated methodology for formal verification of fused-multiply-add floating point units (FPU). Our methodology verifies an implementation FPU against a simple reference model derived from the processor's architectural specification, which may include all aspects of the IEEE specification including denormal operands and exceptions. Our strategy uses a combination of BDD- and SAT-based symbolic simulation. To make this verification task tractable, we use a combination of case-splitting, multiplier isolation, and automatic model reduction techniques. The case-splitting is defined only in terms of the reference model, which makes this approach easily portable to new designs. The methodology is directly applicable to multi-GHz industrial implementation models (e.g., HDL or gate-level circuit representations) that contain all details of the high-performance transistor-level model, such as aggressive pipelining, clocking, etc. Experimental results are provided to demonstrate the computational efficiency of this approach.
Reliable Opto-Electronic Hybrid Interconnection Network

The interconnection network plays a critical role in the cost and performance of a high performance parallel computer and it is closely related with signaling technology. Electrical signaling is inexpensive but limited in range by the frequency dependent attenuation. Emerging optical technology enables new topologies by allowing links to cover large distances but at a significant premium in cost. In addition, parallel transmission presents low latency but its frequency limited by the timing skew. Serial transmission greatly improves the signaling rate but it needs added latency to re-synchronize data. This paper describes the reliable opto-electronic hybrid interconnection network (ROEHIN). ROEHIN exploits emerging high-speed optical and electrical links, parallel and serial transmission to provide cost effective scalability. The ROEHIN router is an 8 times 8 ASIC, which supports adaptive source-base routing and multicast communication. The ROEHIN topology and packaging takes advantage of signaling technology and provides graceful degradation in the presence of faults.
The geographical accessibility of hospitals to the aged: a geographic information systems analysis within Illinois.

OBJECTIVE This article uses geographic information systems and their related tools to empirically measure and display the geographic accessibility of the aged population to hospital facilities within Illinois. DATA SOURCES AND STUDY SETTING Geographic accessibility of Illinois' aged population is measured from each of the state's 10,796 census block groups to the state's 214 hospital facilities. Block group demographic compositions and centroids are obtained from 1990 census files. Hospital coordinates are obtained by the authors. STUDY DESIGN Of five alternative measures of accessibility considered, empirical estimates are obtained for two: choice set and minimum distance. Access to both general hospitals and the subset having specialized geriatric facilities is measured with special attention to differences in accessibility between the aged within metropolitan statistical areas (MSAs) and those outside MSAs. Cumulative accessibility distributions and their summary statistics provide a basis of comparison among subgroups. DATA COLLECTION AND EXTRACTION: Geographic information systems (GIS) and their related tools are used as a means of efficiently capturing, organizing, storing, and retrieving the required data. Hospitals and census block groups are geocoded to specific locations in the database, and aspatial attributes are assigned to the hospitals and block groups. The GIS database is queried to produce shaded isarithm and point distribution maps that show the location of hospitals relative to surrounding aged populations. CONCLUSION The vast majority of Illinois' aged population is within close proximity to hospital facilities. Eighty percent (1,147,504 persons) of the aged in Illinois are within 4.8 miles (7.7 km) of a hospital and 11.6 miles (18.7 km) of two hospitals. However, geographic accessibility differences between the aged living in MSAs and those living outside MSAs to hospitals offering geriatric services are substantial; but there is no evidence that the aged's geographical accessibility to hospitals is less favorable than that of the general population. Detailed accessibility measures permitted by geographic information system technology call into question the continued use of crude empirical accessibility measures.
Emerging targets in pancreatic cancer: epithelial–mesenchymal transition and cancer stem cells

Pancreatic ductal adenocarcinoma is one of the most aggressive solid malignancies and is characterized by poor response to current therapy and a dismal survival rate. Recent insights regarding the role of cancer stem cells (CSCs) and epithelial–mesenchymal transition (EMT) in tumorigenesis have brought further understanding to the field and have highlighted new therapeutic targets. CSCs are a distinct subset of cancer cells, with the ability to differentiate into other cell types and self-renew in order to fuel the maintenance of tumor amplification. Transition of a cancer cell from an EMT leads to increased migratory and invasive properties, and thus facilitates initiation of metastasis. EMT is regulated by a complex network of factors that includes cytokines, growth factors, aberrant signaling pathways, transcription factors, and the tumor microenvironment. There is emerging evidence that the EMT process may give rise to CSCs, or at least cells with stem cell-like properties. We review the key pathways involved in both of these processes, the biomarkers used to identify CSCs, and new therapeutic approaches targeting CSCs and EMT in pancreatic ductal adenocarcinoma.
Denoising of Computed Tomography Images using Wavelet Transform

Image denoising is one of the most significant tasks in image processing, analysis and image processing applications. Medical Imaging is one among the emerging application areas where the image denoising plays a vital role. In medical imaging, the additional techniques and systems introduce noises and artifacts in the medical image that leads to poor quality image. In this moment, image denoising is an essential pre-requisite, specially in Computed Tomography, which is an important and most common method in medical imaging. The significance of the denoising is mainly due to that the effectiveness of clinical diagnosis using CT image depends upon the quality of the image. In this work, we propose an efficient noise reduction technique for CT images using wavelet transformation and thresholding. The technique removes Additive noise from the CT images as well as it enhances the quality of the images.
Revisiting epidermal growth factor receptor in glioblastoma multiforme: does it play a role in response to therapy?

BACKGROUND AND AIM Glioblastoma multiforme (GBM) are the most aggressive class of cancer of central nervous system with hallmark characteristics that include rampant proliferation, necrosis, and endothelial proliferation. Epidermal growth factor receptor (EGFR) has been implicated as the primary contributor to glioblastoma initiation and succession. The present study was designed to evaluate EGFR protein expression in GBM as predictor of response to therapy and survival. MATERIALS AND METHODS Epidermal growth factor receptor was assessed by immunohistochemistry as a percentage of positive tumor cells in hot spots (10 high-power fields). The study group comprised of 35 cases of GBM. All cases underwent surgical resection and subsequently underwent radiotherapy (n = 17) or radiotherapy with adjuvant temozolomide chemotherapy (n = 18). Immediate response to therapy was assessed at 3 months using World Health Organization response evaluation criteria in solid tumors criteria and cases followed up for survival. RESULTS Twenty-four cases (68.6%) expressed EGFR while 11/35 (31.4%) cases were negative. Response to therapy was evident in 21/35 cases (60.0%) and 14/35 were (40.0%) nonresponders. Mean EGFR protein expression in responders was 37.23 ± 33.70 and in nonresponders was 59.5 ± 39.46 (P = 0.542). The percentage of responders which were EGFR negative was 72.7% and while response in EGFR positive cases was observed in 54.2%. Mean survival in EGFR positive and negative GBM was 394.37 ± 189.11 and 420.54 ± 191.23 days, respectively. CONCLUSION The EGFR negative cases appear to respond better to therapy, however, the difference is not statistically significant (P = 0.298). Further, EGFR protein expression does not play a definitive role in predicting survival. This is an original study evaluating EGFR in terms of therapeutic response.
Internal marketplace as a mechanism for promoting software reuse

Reuse is one of the classic ways to improve productivity in software development. Indeed, beneﬁting from software components, patterns, and solutions that have been developed in the company potentially leads to savings in all phases of software intensive work. However, putting such an approach to practice is far from being simple. In particular, when considering software companies that specialize in customer-speciﬁc software projects, it is common that similar designs and technology choices are made in parallel without project-crossing knowledge. In such settings, there is a lack of a systematic approach between projects to spread good practices or to eliminate bad ones. In this paper, we propose solving such problems with an information system that acts as a marketplace for promoting software reuse within a project organization, much to the same ﬂavor as app stores are used to promote mobile applications. The paper provides insight to the design of our prototype system, as well as contains preliminary views from users in one organization.
Mutations of the Cardiac Ryanodine Receptor (RyR2) Gene in Familial Polymorphic Ventricular Tachycardia

Background —Familial polymorphic ventricular tachycardia is an autosomal-dominant, inherited disease with a relatively early onset and a mortality rate of ≈30% by the age of 30 years. Phenotypically, it is characterized by salvoes of bidirectional and polymorphic ventricular tachycardias in response to vigorous exercise, with no structural evidence of myocardial disease. We previously mapped the causative gene to chromosome 1q42-q43. In the present study, we demonstrate that patients with familial polymorphic ventricular tachycardia have missense mutations in the cardiac sarcoplasmic reticulum calcium release channel (ryanodine receptor type 2 [RyR2]). Methods and Results —In 3 large families studied, 3 different RyR2 mutations (P2328S, Q4201R, V4653F) were detected and shown to fully cosegregate with the characteristic arrhythmic phenotype. These mutations were absent in the nonaffected family members and in 100 healthy controls. In addition to identifying 3 causative mutations, we identified a number of single nucleotide polymorphisms that span the genomic structure of RyR2 and will be useful for candidate-based association studies for other arrhythmic disorders. Conclusions —Our data illustrate that mutations of the RyR2 gene cause at least one variety of inherited polymorphic tachycardia. These findings define a new entity of disorders of myocardial calcium signaling.
Use of Oligoarrays for Characterization of Community-Onset Methicillin-Resistant Staphylococcus aureus

ABSTRACT Until recently, methicillin-resistant Staphylococcus aureus (MRSA) was considered the prototype of a hospital-acquired bacterial pathogen. However, recent reports have shown that MRSA has now emerged in the community. Characterization of specific markers for distinguishing the origin of isolates could contribute to improved knowledge of MRSA epidemiology. The release of whole-genome sequences of hospital- and community-acquired S. aureus strains allowed the development of whole-genome content analysis techniques, including microarrays. We developed a microarray composed of 8,191 open reading frame-specific oligonucleotides covering >99% of the four sequenced S. aureus genomes (N315, Mu50, MW2, and COL) to evaluate gene contents of hospital- and community-onset S. aureus strains. In parallel, pulsed-field gel electrophoresis, variable number of tandem repeats, antibiogram, staphylococcal cassette chromosome-mec element typing, and presence of the Panton-Valentine leukocidin gene were evaluated in a collection of 15 clinical isolates. Clusters obtained with microarrays showed a high degree of similarity with those obtained by pulsed-field gel electrophoresis or variable number of tandem repeats. Clusters clearly segregated hospital-onset strains from community-onset strains. Moreover, the microarray approach allowed definition of novel marker genes and chromosomal regions specific for given groups of isolates, thus providing better discrimination and additional information compared to pulsed-field gel electrophoresis and variable number of tandem repeats. Finally, the comparative genome hybridization approach unraveled the occurrence of multiple horizontal transfer events leading to community-onset MRSA as well as the need for a specific genetic background in recipient strains for both the acquisition and the stability of the mec element.
Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation

In the resolution of inflammatory responses, neutrophils rapidly undergo apoptosis. We describe a new proapoptotic pathway in which cathepsin D directly activates caspase-8. Cathepsin D is released from azurophilic granules in neutrophils in a caspase-independent but reactive oxygen species–dependent manner. Under inflammatory conditions, the translocation of cathepsin D in the cytosol is blocked. Pharmacological or genetic inhibition of cathepsin D resulted in delayed caspase activation and reduced neutrophil apoptosis. Cathepsin D deficiency or lack of its translocation in the cytosol prolongs innate immune responses in experimental bacterial infection and in septic shock. Thus, we identified a new function of azurophilic granules that is in addition to their role in bacterial defense mechanisms: to regulate the life span of neutrophils and, therefore, the duration of innate immune responses through the release of cathepsin D.
EXPLORING CELLULAR TENSEGRITY: PHYSICAL MODELING AND COMPUTATIONAL SIMULATION

The term tensegrity was first coined by Buckminster Fuller to describe a structure in which continuous tension in its members forms the basis for structural integrity. Fuller most famously demonstrated the concept of tensegrity in architecture through the design of geodesic domes while his student, artist Kenneth Snelson, applied the concept of tensegrity to create sculptures that appear to defy gravity (Figure 1). Snelson’s tensegrity sculptures have minimal components and achieve their stability through dynamic distribution of tensile and compressive forces amongst their members to create internal balance [1]. It was upon viewing Snelson’s sculptures that Donald Ingber became inspired by their structural efficiency and dynamic force balance to adopt tensegrity as a paradigm upon which to analyze cell structure and mechanics. It has been 30 years since the premier appearance of the cellular tensegrity model and although the model is still much under debate, empirical evidence suggests that the model may explain a wide variety of phenomena ranging from tumor growth to cell motility [1–4]. Copyright © 2008 by ASME
Ecological and Control Techniques for Sand Flies (Diptera: Psychodidae) Associated with Rodent Reservoirs of Leishmaniasis

Background Leishmaniasis remains a global health problem because of the substantial holes that remain in our understanding of sand fly ecology and the failure of traditional vector control methods. The specific larval food source is unknown for all but a few sand fly species, and this is particularly true for the vectors of Leishmania parasites. We provide methods and materials that could be used to understand, and ultimately break, the transmission cycle of zoonotic cutaneous leishmaniasis. Methods and Findings We demonstrated in laboratory studies that analysis of the stable carbon and nitrogen isotopes found naturally in plant and animal tissues was highly effective for linking adult sand flies with their larval diet, without having to locate or capture the sand fly larvae themselves. In a field trial, we also demonstrated using this technique that half of captured adult sand flies had fed as larvae on rodent feces. Through the identification of rodent feces as a sand fly larval habitat, we now know that rodent baits containing insecticides that have been shown in previous studies to pass into the rodents' feces and kill sand fly larvae also could play a future role in sand fly control. In a second study we showed that rubidium incorporated into rodent baits could be used to demonstrate the level of bloodfeeding by sand flies on baited rodents, and that the elimination of sand flies that feed on rodents can be achieved using baits containing an insecticide that circulates in the blood of baited rodents. Conclusions Combined, the techniques described could help to identify larval food sources of other important vectors of the protozoa that cause visceral or dermal leishmaniasis. Unveiling aspects of the life cycles of sand flies that could be targeted with insecticides would guide future sand fly control programs for prevention of leishmaniasis.
The Genetic and Environmental Factors for Keratoconus

Keratoconus (KC) is the most common cornea ectatic disorder. It is characterized by a cone-shaped thin cornea leading to myopia, irregular astigmatism, and vision impairment. It affects all ethnic groups and both genders. Both environmental and genetic factors may contribute to its pathogenesis. This review is to summarize the current research development in KC epidemiology and genetic etiology. Environmental factors include but are not limited to eye rubbing, atopy, sun exposure, and geography. Genetic discoveries have been reviewed with evidence from family-based linkage analysis and fine mapping in linkage region, genome-wide association studies, and candidate genes analyses. A number of genes have been discovered at a relatively rapid pace. The detailed molecular mechanism underlying KC pathogenesis will significantly advance our understanding of KC and promote the development of potential therapies.
Activation of the Leukocyte NADPH Oxidase by Protein Kinase C in a Partially Recombinant Cell-free System*

The leukocyte NADPH oxidase is an enzyme present in phagocytes and B lymphocytes that when activated catalyzes the production of O⨪2 from oxygen at the expense of NADPH. A correlation between the activation of the oxidase and the phosphorylation of p47 PHOX , a cytosolic oxidase component, is well recognized in whole cells, and direct evidence for a relationship between the phosphorylation of this oxidase component and the activation of the oxidase has been obtained in a number of cell-free systems containing neutrophil membrane and cytosol. Using superoxide dismutase-inhibitable cytochrome c reduction to quantify O⨪2 production, we now show that p47 PHOX phosphorylated by protein kinase C activates the NADPH oxidase not only in a cell-free system containing neutrophil membrane and cytosol, but also in a system in which the cytosol is replaced by the recombinant proteins p67 PHOX , Rac2, and phosphorylated p47 PHOX , suggesting that neutrophil plasma membrane plus those three cytosolic proteins are both necessary and sufficient for oxidase activation. In both the cytosol-containing and recombinant cell-free systems, however, activation by SDS yielded greater rates of O⨪2 production than activation by protein kinase C-phosphorylated p47 PHOX , indicating that a system that employs protein kinase C-phosphorylated p47 PHOX as the sole activating agent, although more physiological than the SDS-activated system, is nevertheless incomplete.
Secretory traffic in the eukaryotic parasite Toxoplasma gondii

Name a single-celled eukaryote that boasts a small genome size, is easily cultivated in haploid form, for which a wide variety of molecular genetic tools are available, and that exhibits a simple, polarized secretory apparatus with a well-defined endoplasmic reticulum and Golgi that can serve as a model for understanding secretion. Got it? Now name a cell with all these attributes that contains at least a dozen distinct and morphologically well-defined intracellular organelles, including three distinct types of secretory vesicles and two endosymbiotic organelles. Not so sure anymore?