Miracle-dz/UniFAR-FTUs huggingface dataset:
Cloud Computing and the Business Consequences of ERP use

A Cloud Computing system is intended to improve and automate the controlling single point operations. By using a single point of control, this goal is accomplished through the elimination of duplicate entry and the contribution of data integrity, detailed drilldown, simple training, manageable support, minimal IT maintenance, easy upgrades and reduced costs. Overall, the advantages of cloud computing usage fulfill the original intentions of business as it allows process manufacturers to manage their business as simply and efficiently as possible. Enterprise Resource Planning (ERP) software is designed to improve and auto-mate business processes operations. However, there are many unnecessary administrative, procedural costs and delays often associated with this practice. Examples include duplicate data entry, data corruption, increased training, complicated supplier relations, greater IT support and software incompatibilities. Purpose of this system is Single Point of Control, Duplicate Entry Elimination, Data Integrity, Detail Drill Down, Basic Training, Manage Support, Security, Minimal IT Maintenance, Easy Upgrades, and Reduce Costs etc.
Bilateral connectivity in the somatosensory region using near-infrared spectroscopy (NIRS) by wavelet coherence

Near-infrared spectroscopy (NIRS) has been used in medical imaging to obtain oxygenation and hemodynamic response in the cerebral cortex. This technique has been applied in cortical activation detection and functional connectivity in brain research. Despite some advances in functional connectivity, most of the studies have focused on the prefrontal cortex and little has been done to study the somatosensory region (S1). For that reason, the aim of our present study is to assess bilateral connectivity in the somatosensory region by using NIRS and noxious stimulation. Eleven healthy subjects were investigated using near-infrared spectroscopy during an acupuncture stimulation procedure to safely induce pain in subjects. A multiscale analysis based on wavelet transform coherence (WTC) was designed to assess the functional connectivity of corresponding channel pairs within the left and right s1 region. The cortical activation in the somatosensory region was higher after the acupuncture stimulation, which was consistent with similar studies. The coherence in time-frequency domain between homologous signals generated by contralateral channel pairs revealed two main periods (3.2 s and 12.8 s) with high coherence. Based on the WTC analysis, it was also found that the coherence increase in these periods was task-related. This study contributes to the research field to investigate cerebral hemodynamic response of pain perception using NIRS and demonstrates the use of wavelet transform as a method to investigate functional lateralization in the cerebral cortex.
Mild head injury increasing the brain's vulnerability to a second concussive impact.

OBJECT Mild, traumatic repetitive head injury (RHI) leads to neurobehavioral impairment and is associated with the early onset of neurodegenerative disease. The authors developed an animal model to investigate the behavioral and pathological changes associated with RHI. METHODS Adult male C57BL/6 mice were subjected to a single injury (43 mice), repetitive injury (two injuries 24 hours apart; 49 mice), or no impact (36 mice). Cognitive function was assessed using the Morris water maze test, and neurological motor function was evaluated using a battery of neuroscore, rotarod, and rotating pole tests. The animals were also evaluated for cardiovascular changes, blood-brain barrier (BBB) breakdown, traumatic axonal injury, and neurodegenerative and histopathological changes between 1 day and 56 days after brain trauma. No cognitive dysfunction was detected in any group. The single-impact group showed mild impairment according to the neuroscore test at only 3 days postinjury, whereas RHI caused pronounced deficits at 3 days and 7 days following the second injury. Moreover, RHI led to functional impairment during the rotarod and rotating pole tests that was not observed in any animal after a single impact. Small areas of cortical BBB breakdown and axonal injury. observed after a single brain injury, were profoundly exacerbated after RHI. Immunohistochemical staining for microtubule-associated protein-2 revealed marked regional loss of immunoreactivity only in animals subjected to RHI. No deposits of beta-amyloid or tau were observed in any brain-injured animal. CONCLUSIONS On the basis of their results, the authors suggest that the brain has an increased vulnerability to a second traumatic insult for at least 24 hours following an initial episode of mild brain trauma.
Kinematic control algorithms for on-line obstacle avoidance for redundant manipulators

The paper deals with kinematic control algorithms for on-line obstacle avoidance which allow a kinematically redundant manipulator to move in an unstructured environment without colliding with obstacles. The presented approach is based on the redundancy resolution at the velocity level. The primary task is determined by the end-effector trajectories and for obstacle avoidance the internal motion of the manipulator is used. The obstacle avoiding motion is defined in one-dimensional operational space and, hence, the system has less singularities making implementation easier. Instead of the exact pseudoinverse solution we propose an approximate one which is computationally more efficient and allows us to consider many simultaneously active obstacles without any problems. The fast cycle times of the numerical implementation enable use of the algorithm in real-time control. For illustration, some simulation results of a highly redundant planar manipulator moving in an unstructured and time-varying environment and experimental results of a four link planar manipulator are given.
Design of High Speed 32 Bit Truncation-Error- Tolerant Adder

In this project, we had proposed architecture for high speed Truncation Adder Algorithm. In modern VLSI technology, the occurrence of all kinds of errors has always to be expected. By adopting and introducing a novel error-tolerant adder in VLSI design. This error-tolerant adder is easy to develop the accuracy out puts and at the same time it achieves tremendous improvements in both the power consumption and speed performance. By comparing previous or conventional counter parts and error- tolerant adder the proposed ETA is to be attain more than 74% improvements in power-delay products. One important potential application of the proposed ETA is in digital signal processing systems that can tolerate certain amount of errors.
mARGraphy: Mobile AR-based Dynamic Information Visualization

We propose a mARGraphy, which visualizes information based on augmented reality (AR) technology. It provides the intuitive and interactive way to make users to understand dynamic 3D information in situ with highly relevant to the target. To show the effectiveness of our work, we introduce a traditional map viewer application. It recognizes region of a traditional map with object recognition and tracking method on a mobile platform. Then, it aggregates dynamic information obtained from database such as geographical features with temporal changes, and situational contexts. For the verification of this work, we observed how our system improves users' understanding information with mARGraphy through preliminary user study.
The ambiguity of pride

This work aims to account for the complexity of pride, while also trying to clear some ambiguities that in our view result from unwarranted assumptions about its two facets—“authentic” versus “hubristic” pride. We propose a model of pride in terms of its cognitive and motivational components; distinguish two kinds of pride proper: pride1, referring to achievement-based pride and pride2, concerning one’s stable qualities and dispositions; and identify the goals they are likely to elicit. We also argue that for pride to be felt, it is insufficient and even unnecessary that one’s self-evaluations should concern socially valued accomplishments. We suggest that hubris is distinguishable from both kinds of pride proper because, unlike the latter, it is qualified by the goal of superiority over others, and we consider its implications in terms of social attitudes. We also discuss whether hubris is a form of “false” pride.
Identification of a Novel Protein Kinase A Anchoring Protein That Binds Both Type I and Type II Regulatory Subunits*

Compartmentalization of cAMP-dependent protein kinase is achieved in part by interaction with A-kinase anchoring proteins (AKAPs). All of the anchoring proteins identified previously target the kinase by tethering the type II regulatory subunit. Here we report the cloning and characterization of a novel anchoring protein, D-AKAP1, that interacts with the N terminus of both type I and type II regulatory subunits. A novel cDNA encoding a 125-amino acid fragment of D-AKAP1 was isolated from a two-hybrid screen and shown to interact specifically with the type I regulatory subunit. Although a single message of 3.8 kilobase pairs was detected for D-AKAP1 in all embryonic stages and in most adult tissues, cDNA cloning revealed the possibility of at least four splice variants. All four isoforms contain a core of 526 amino acids, which includes the R binding fragment, and may be expressed in a tissue-specific manner. This core sequence was homologous to S-AKAP84, including a mitochondrial signal sequence near the amino terminus (Lin, R. Y., Moss, S. B., and Rubin, C. S. (1995) J. Biol. Chem. 270, 27804-27811). D-AKAP1 and the type I regulatory subunit appeared to have overlapping expression patterns in muscle and olfactory epithelium by in situ hybridization. These results raise a novel possibility that the type I regulatory subunit may be anchored via anchoring proteins.
An indicator of appropriate neuroleptic prescribing in nursing homes.

OBJECTIVE To derive and apply objective criteria which assess the appropriateness of neuroleptic prescribing, in a random sample of nursing homes. DESIGN Cross-sectional survey of prescribing in a random sample of nursing homes. SETTING 22 homes with more than 35 residents in the former South Thames Region. SUBJECTS 934 nursing home residents aged 65 years or over. METHODS We compared criteria of appropriate neuroleptic prescribing, including appropriate indication and review, to clinical data documented in the nursing and GP notes of residents prescribed neuroleptics. RESULTS Of the 229 (24.5%) residents prescribed neuroleptics, clinical notes were available for 225. Clinical data indicated that only 40/225 (17.8%) residents receiving neuroleptics received appropriate therapy. The intra-cluster correlations for appropriate and inappropriate prescribing of neuroleptics were 0.038 and 0.12 respectively. It was not possible to derive reference ranges of observed prescribing that included homes demonstrating appropriate prescribing whilst excluding those with inappropriate prescribing. Thus, clinical data are needed whenever neuroleptic appropriateness is assessed. Criteria were readily applicable in nursing homes. CONCLUSION Application of criteria of appropriate neuroleptic prescribing in a random sample of nursing homes identified suboptimal prescribing to elderly residents.
Characterization of early pathogenesis in the SOD1G93A mouse model of ALS: part II, results and discussion

Pathological events are well characterized in amyotrophic lateral sclerosis (ALS) mouse models, but review of the literature fails to identify a specific initiating event that precipitates disease pathology. There is now growing consensus in the field that axon and synapses are first cellular sites of degeneration, but controversy exists over whether axon and synapse loss is initiated autonomously at those sites or by pathology in the cell body, in nonneuronal cells or even in nonmotoneurons (MNs). Previous studies have identified pathological events in the mutant superoxide dismutase 1 (SOD1) models involving spinal cord, peripheral axons, neuromuscular junctions (NMJs), or muscle; however, few studies have systematically examined pathogenesis at multiple sites in the same study. We have performed ultrastructural examination of both central and peripheral components of the neuromuscular system in the SOD1G93A mouse model of ALS. Twenty percent of MNs undergo degeneration by P60, but NMJ innervation in fast fatigable muscles is reduced by 40% by P30. Gait alterations and muscle weakness were also found at P30. There was no change in axonal transport prior to initial NMJ denervation. Mitochondrial morphological changes are observed at P7 and become more prominent with disease progression. At P30 there was a significant decrease in excitatory axo‐dendritic and axo‐somatic synapses with an increase in C‐type axo‐somatic synapses. Our study examined early pathology in both peripheral and central neuromuscular system. The muscle denervation is associated with functional motor deficits and begins during the first postnatal month in SOD1G93A mice. Physiological dysfunction and pathology in the mitochondria of synapses and MN soma and dendrites occur, and disease onset in these animals begins more than 2 months earlier than originally thought. This information may be valuable for designing preclinical trials that are more likely to impact disease onset and progression.
Agreement and disagreement classification of dyadic interactions using vocal and gestural cues

In human-to-human communication gesture and speech co-exist in time with a tight synchrony, where we tend to use gestures to complement or to emphasize speech. In this study, we investigate roles of vocal and gestural cues to identify a dyadic interaction as agreement and disagreement. In this investigation we use the JESTKOD database, which consists of speech and full-body motion capture data recordings for dyadic interactions under agreement and disagreement scenarios. Spectral features of vocal channel and upper body joint angles of gestural channel are employed to extract unimodal and multimodal classification performances. Both of the modalities attain classification rates significantly above the chance level and the multimodal classifier performed more than 80% classification rate over 15 second utterances using statistical features of speech and motion.
Slow phases of GABAA receptor desensitization: structural determinants and possible relevance for synaptic function

GABAA receptor fast desensitization is thought to shape the time course of individual IPSCs. Although GABAA receptors also exhibit slower phases of desensitization, the possible role of slow desensitization in modifying synaptic function is poorly understood. In transiently transfected human embryonic kidney (HEK293T) cells, rat α1β3δ and α1β3γ2L GABAA receptors showed distinct desensitization patterns during long (28 s) concentration jumps using a saturating (1 mm) GABA concentration. α1β3γ2L receptors desensitized extensively (≈90 %), with four phases (τ1≈20 ms, τ2≈400 ms, τ3≈2 s, τ4≈10 s), while α1β3δ receptors desensitized slowly and less extensively (≈35 %), with one or two slow phases with time constants similar to τ3 and τ4 of α1β3γ2L receptors. To determine the structural basis of subunit‐specific desensitization, δ‐γ2L chimera subunits were expressed with α1 and β3 subunits. Replacing the entire N‐terminus of the γ2L subunit with δ subunit sequence did not alter the number of phases or the extent of desensitization. Although extension of δ subunit sequence into transmembrane domain 1 (TM1) abolished the fast and intermediate components of desensitization, the two slow phases still accounted for substantial current loss (≈65 %). However, when δ subunit sequence was extended through TM2, the extent of desensitization was significantly decreased and indistinguishable from that of α1β3δ receptors. The importance of TM2 sequence was confirmed by introducing γ2 subunit TM2 residues into the δ subunit, which significantly increased the extent of desensitization, without introducing either the fast or intermediate desensitization phases. However, introducing δ subunit TM2 sequence into the γ2L subunit had minimal effect on the rates or extent of desensitization. The results suggest that distinct δ subunit structures are responsible for its unique desensitization properties: lack of fast and intermediate desensitization and small contribution of the slow phases of desensitization. Finally, to investigate the possible role of slow desensitization in synaptic function, we used a pulse train protocol. We observed inhibition of peak current amplitude that depended on the frequency and duration of GABA pulses for receptors exhibiting extensive desensitization, whether fast phases were present or not. The minimally desensitizing α1β3δ receptor exhibited negligible inhibition during pulse trains. Because receptors that desensitized without the fast and intermediate phases showed pulse train inhibition, we concluded that receptors can accumulate in slowly equilibrating desensitized states during repetitive receptor activation. These results may indicate a previously unrecognized role for the slow phases of desensitization for synaptic function under conditions of repeated GABAA receptor activation.
Robust convention emergence in social networks through self-reinforcing structures dissolution

Convention emergence solves the problem of choosing, in a decentralized way and among all equally beneficial conventions, the same convention for the entire population in the system for their own benefit. Our previous work has shown that reaching 100% agreement is not as straighforward as assumed by previous researchers, that, in order to save computational resources fixed the convergence rate to 90% (measuring the time it takes for 90% of the population to coordinate on the same action). In this article we present the notion of social instruments as a set of mechanisms that facilitate and accelerate the emergence of norms from repeated interactions between members of a society, only accessing local and public information and thus ensuring agents' privacy and anonymity. Specifically, we focus on two social instruments: rewiring and observation. Our main goal is to provide agents with tools that allow them to leverage their social network of interactions while effectively addressing coordination and learning problems, paying special attention to dissolving metastable subconventions. The first experimental results show that even with the usage of the proposed instruments, convergence is not accelerated or even obtained in irregular networks. This result leads us to perform an exhaustive analysis of irregular networks discovering what we have defined as Self-Reinforcing Structures (SRS). The SRS are topological configurations of nodes that promote the establishment and persistence of subconventions by producing a continuous reinforcing effect on the frontier agents. Finally, we propose a more sophisticated composed social instrument (observation + rewiring) for robust resolution of subconventions, which works by the dissolution of the stable frontiers caused by the Self-Reinforcing Substructures (SRS) within the social network.
Potpourri, 10

Let (M, d(x, y)) be a metric space. Thus M is a nonempty set and d(x, y) is a real-valued function defined for x, y ∈ M such that d(x, y) ≥ 0 for all x, y ∈ M , d(x, y) = 0 if and only if x = y, d(x, y) = d(y, x) for all x, y ∈ M , and d(x, z) ≤ d(x, y) + d(y, z) (1) for all x, y, z ∈ M. If we have the stronger condition that d(x, z) ≤ max(d(x, y), d(y, z)) (2) for all x, y, z ∈ M , then we say that d(x, y) is an ultrametric on M. Of course the real line R with the standard metric |x − y| is a metric space. We shall discuss some more examples soon. Let (M, d(x, y)) be a metric space, and let E be a subset of M. We say that E is bounded if the collection of real numbers d(x, y), x, y ∈ E are bounded, and in this event we define the diameter of E by diam E = sup{d(x, y) : x, y ∈ E}. The diameter of the empty set is defined to be 0, and we can also define the diameter of an unbounded subset of M to be +∞. For each p ∈ M and r > 0 define the open and closed balls in M with center p and radius r by B(p, r) = {x ∈ M : d(x, p) < r} (4) and B(p, r) = {x ∈ M : d(x, p) ≤ r}, (5) respectively. Thus B(p, r) ⊆ B(p, r) (6) and diam B(p, r) ≤ 2 r (7)
Ultrasonic transducer positioning system for clamp-on flowmeter applications

The positions of the ultrasonic transducers of clamp-on flowmeters have a determining influence on the precision and the accuracy of the measurement results. In this paper a transducer positioning system for ultrasonic clamp-on sensor applications is presented. It was designed in result of studies of the sensitivity and works automatically. The positioning system found an optimal transducer position for a special application by itself. So, the user can operate the clamp-on flowmeter with neither finding out some special information of the application process nor setting any parameters in the system before.
Microsatellite Genotyping of Plasmodium vivax Isolates from Pregnant Women in Four Malaria Endemic Countries

Plasmodium vivax is the most widely distributed human parasite and the main cause of human malaria outside the African continent. However, the knowledge about the genetic variability of P. vivax is limited when compared to the information available for P. falciparum. We present the results of a study aimed at characterizing the genetic structure of P. vivax populations obtained from pregnant women from different malaria endemic settings. Between June 2008 and October 2011 nearly 2000 pregnant women were recruited during routine antenatal care at each site and followed up until delivery. A capillary blood sample from the study participants was collected for genotyping at different time points. Seven P. vivax microsatellite markers were used for genotypic characterization on a total of 229 P. vivax isolates obtained from Brazil, Colombia, India and Papua New Guinea. In each population, the number of alleles per locus, the expected heterozygosity and the levels of multilocus linkage disequilibrium were assessed. The extent of genetic differentiation among populations was also estimated. Six microsatellite loci on 137 P. falciparum isolates from three countries were screened for comparison. The mean value of expected heterozygosity per country ranged from 0.839 to 0.874 for P. vivax and from 0.578 to 0.758 for P. falciparum. P. vivax populations were more diverse than those of P. falciparum. In some of the studied countries, the diversity of P. vivax population was very high compared to the respective level of endemicity. The level of inter-population differentiation was moderate to high in all P. vivax and P. falciparum populations studied.