Miracle-dz/UniFAR-FTUs huggingface dataset:
Punto de corte de homeostasis model assessment (HOMA-IR) para determinar insulinorresistencia en individuos adultos del municipio Maracaibo-Estado Zulia, Venezuela

Insulin Resistance (IR) is an important finding in several diseases including diabetes and metabolic syndrome, and its diagnosis seems pertinent during the evaluation of insulin sensitivity, though mathematical models like HOMA (Homeostasis Model Assessment). The purpose of the present study was to determine an appropriate cutpoint for HOMA-IR in adult individuals from the Maracaibo municipality, Zulia state, Venezuela. Two-thousand and twenty-six individuals from both sexes and beyond 18 years of age were selected from the Maracaibo city Metabolic Syndrome Prevalence Study, a descriptive cross-sectional study with multietapic sampling. HOMA-IR was calculated using the formula [Fasting Insulin (µU/L) x Fasting Glycemia (mmol/L)/22,5]. To estimate the cutpoint, 602 healthy individuals were selected and a percentile distribution was calculates, alongside ROC Curve in order to identify the best cutoff point according to sensitivity and specificity. Overall, the average HOMA-IR was 3,71±3,01, with 3,65±2,96 for women and 3,76±3,06 for men (p=0,397). Using the reference population, the resulting arithmetic value was 2,64±1,67. When distributing per percentile, p75 was 3,02. When selecting a cutpoint using ROC Curve, the chosen cutoff point was 3.03 with an Area Under the Curve of 0.814 (75,2% sensitivity and 75,6% specificity). The obtained results are good enough to propose a cutpoint of 3,00 for HOMA-IR, which can be use in the clinical evaluation of IR in adults from our population.
Predicting the impact of scientific concepts using full‐text features

New scientific concepts, interpreted broadly, are continuously introduced in the literature, but relatively few concepts have a long‐term impact on society. The identification of such concepts is a challenging prediction task that would help multiple parties—including researchers and the general public—focus their attention within the vast scientific literature. In this paper we present a system that predicts the future impact of a scientific concept, represented as a technical term, based on the information available from recently published research articles. We analyze the usefulness of rich features derived from the full text of the articles through a variety of approaches, including rhetorical sentence analysis, information extraction, and time‐series analysis. The results from two large‐scale experiments with 3.8 million full‐text articles and 48 million metadata records support the conclusion that full‐text features are significantly more useful for prediction than metadata‐only features and that the most accurate predictions result from combining the metadata and full‐text features. Surprisingly, these results hold even when the metadata features are available for a much larger number of documents than are available for the full‐text features.
Hindfoot Deformity and Calcaneal Tuberosity Osteotomies

Calcaneal tuberosity osteotomies are commonly used to treat coronal plane deformities of the hindfoot. Assessing hindfoot alignment can be difficult and there is little evidence to guide the physician when considering the surgical treatment of these deformities. The indications for a calcaneal osteotomy are unclear in the literature because most of the published studies supporting their use are confounded by concurrent procedures such as in adult-acquired flatfoot correction or cavovarus reconstruction. For the same reason, the biomechanical consequences, long-term effects, and performance in vivo are largely unknown. Level of Evidence: Expert opinion, Level V
Long-Term Effect of Curing Temperature on the Strength Behavior of Cement-Stabilized Clay

The influence of curing temperature on the strength development of concrete, mortar, or cement-stabilized granular soils has been widely reported in the literature. However, there are fewer studies focusing on cement-stabilized clay. The key difference is the presence of pozzolanic reactions in cement-stabilized clay, which give rise to more complex strength-development behaviors than those of concrete, mortar, or cement-stabilized granular soils. This paper aims to clarify this difference using extensive data collected as part of a land reclamation project in Singapore. Five different mixes of cement-stabilized Singapore marine clay are cured under different temperatures. Their strength development with time is studied by testing the specimens under unconfined compression at various curing ages (up to 1 year). The experimental results show that a higher curing temperature gives rise to not only higher short-term strengths but also higher long-term/ultimate strengths. Based on the experimental results, a model is proposed that combines the maturity theory commonly used for concrete or mortar with a proposed temperature-enhanced strength factor, which takes into account the effect of curing temperature on pozzolanic reactions occurring in cement-stabilized clay. This proposed model is validated by another independent Singapore data set and data sets collected from the literature.
Anesthetic Management for Multiple Family Members with Myotonic Dystrophy for Interventional Cardiac Procedures—A Case Series

Myotonic muscular dystrophy (MMD) is a rare autosomal dominant disorder that can complicate anesthetic management of patients. MMD is characterized by progressively worsening muscle loss and weakness, cardiac conduction abnormalities, cardiomyopathy, restrictive lung disease, obstructive sleep apnea, and delayed gastric emptying. Patients presenting with MMD for any surgical procedure present a management challenge to the anesthesiologist. Several reports of airway loss due to medication-mediated respiratory depression, sudden death due to dysrhythmias, aspiration of stomach contents, and prolonged intubation have been reported. We present a case series of three family members with MMD type 1 who presented for electrophysiologic assessment of the cardiac conduction system and possible pacemaker insertion. While there are reports of anesthetic management of patients with myotonic dystrophy for various procedures, our report is unique in that we were able to demonstrate variations of anesthetic management based on the procedure and variation in disease phenotype—differing severity between family members.
Hantaviruses and hantavirus pulmonary syndrome.

logical testing and autopsy findings did not indicate any known cause of acute respiratory illness and shock. Persons who were affected lived in rural areas of northwestern New Mexico and northeastern Arizona, but there was no obvious epidemiologic connection between patients. Recognition and reporting of this outbreak led to an unprecedented multiagency response that involved the collaborative efforts of clinicians, field epidemiologists, biologists, laboratory researchers, and public health educators. Specimens from the patients were tested for a wide variety of agents at the Centers for Disease Control and Prevention (CDC) [1]. Within 3 weeks of the recognition of the outbreak, the first evidence of the cause of illness was found. IgM and IgG antibodies to several hantaviruses were detected in the sera of patients with use of enzyme immunoassay (EIA), suggesting that illness was due to a previously unrecognized but serologically cross-reactive hantavirus. Additional evidence that a hantavirus was the etiologic agent accumulated in short order. Antigen was detected in the endothelia of multiple organs of these patients on immunohistochemical testing when a monoclonal antibody reactive with conserved hantaviral nucleoprotein epitopes was used, and hantaviral nucleotide sequences were detected in patient tissue specimens by reverse transcriptase polymerase chain reaction (RT-PCR). Nichol and colleagues [2] confirmed that the etiologic agent was a unique hantavirus on the basis of results of nucleotide sequence analysis of RT-PCR-amplified viral genetic material. The respiratory illness associated with hantavirus infection has been designated hantavirus pulmonary syndrome (HPS) [3]. Clinical illness associated with hantavirus infection first
Comparison of source parameters estimated in the frequency and time domains for seismic events at the Rudna copper mine, Poland

Source parameters estimated in the frequency domain for 100 selected seismic events from the Rudna copper mine, with moment magnitude ranging from 1.4 to 3.6, were collected to study their scaling relations and to compare them with the parameters estimated in the time domain. The apparent stress and static stress drop, corrected for the limited bandwidth recording, increase slightly in a similar manner with increasing seismic moment. The ratio of apparent stress to static stress drop, a measure of radiation efficiency, is practically constant and its mean value is close to 0.1. For 37 seismic events, with moment magnitude between 1.9 and 3.4, source parameters were estimated in the time domain from relative source time functions, that displayed unilateral rupture propagation, and their rupture velocity could be estimated. It ranges from 0.23 to 0.80 of shear wave velocity and is almost independent of seismic moment. The fault length, estimated from the average source pulse width and rupture velocity, is clearly dependent on seismic moment and is smaller than the source radius estimated from the corner frequency on the average by about 25 percent. There is no correlation between the values of static stress drop estimated in the frequency and time domains, but the time domain stress drop is in general similar to that estimated in the frequency domain. The apparent stress increases with increasing rupture velocity, and the ratio of apparent stress to static stress drop seems also to depend on rupture velocity.
Seven Years and One Day: Sketching the Evolution of Internet Traffic

This contribution aims at performing a longitudinal study of the evolution of the traffic collected every day for seven years on a trans-Pacific backbone link (the MAWI dataset). Long term characteristics are investigated both at TCP/IP layers (packet and flow attributes) and application usages. The analysis of this unique dataset provides new insights into changes in traffic statistics, notably on the persistence of Long Range Dependence, induced by the on-going increase in link bandwidth. Traffic in the MAWI dataset is subject to bandwidth changes, to congestions, and to a variety of anomalies. This allows the comparison of their impacts on the traffic statistics but at the same time significantly impairs long term evolution characterizations. To account for this difficulty, we show and explain how and why random projection (sketch) based analysis procedures provide practitioners with an efficient and robust tool to disentangle actual long term evolutions from time localized events such as anomalies and link congestions. Our central results consist in showing a strong and persistent long range dependence controlling jointly byte and packet counts. An additional study of a 24-hour trace complements the long-term results with the analysis of intraday variabilities.
Optimal parameter value of Zhang equivalence for MVN redundancy resolution at velocity and acceleration levels

The equivalent relationship of two general scheme formulations at joint velocity and joint acceleration levels is established in this paper for robotic redundancy resolution, i.e., the so-called Zhang equivalence (ZE). As one representative case, ZE of the minimum velocity norm (MVN) type (i.e., MVN-type ZE) is further investigated for redundancy resolution. Moreover, computer simulations together with illustrative numerical experiments based on the widely-used robot manipulator PUMA560 show the phenomenon that an optimal equivalence value of the equivalent parameter exists within effective range from two different perspectives of equivalence; and then reveal the optimal value of the equivalent parameter in two situations from such perspectives.
Biomolecular Markers in Cancer of the Tongue

The incidence of tongue cancer is increasing worldwide, and its aggressiveness remains high regardless of treatment. Genetic changes and the expression of abnormal proteins have been frequently reported in the case of head and neck cancers, but the little information that has been published concerning tongue tumours is often contradictory. This review will concentrate on the immunohistochemical expression of biomolecular markers and their relationships with clinical behaviour and prognosis. Most of these proteins are associated with nodal stage, tumour progression and metastases, but there is still controversy concerning their impact on disease-free and overall survival, and treatment response. More extensive clinical studies are needed to identify the patterns of molecular alterations and the most reliable predictors in order to develop tailored anti-tumour strategies based on the targeting of hypoxia markers, vascular and lymphangiogenic factors, epidermal growth factor receptors, intracytoplasmatic signalling and apoptosis.
Inactivation of sll1556 in Synechocystis Strain PCC 6803 Impairs Isoprenoid Biosynthesis from Pentose Phosphate Cycle Substrates In Vitro

ABSTRACT In cyanobacteria many compounds, including chlorophylls, carotenoids, and hopanoids, are synthesized from the isoprenoid precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate. Isoprenoid biosynthesis in extracts of the cyanobacterium Synechocystis strain PCC 6803 grown under photosynthetic conditions, stimulated by pentose phosphate cycle substrates, does not appear to require methylerythritol phosphate pathway intermediates. The sll1556 gene, distantly related to type 2 IPP isomerase genes, was disrupted by insertion of a Kanr cassette. The mutant was fully viable under photosynthetic conditions although impaired in the utilization of pentose phosphate cycle substrates. Compared to the parental strain the Δsll1556 mutant (i) is deficient in isoprenoid biosynthesis in vitro with substrates including glyceraldehyde-3-phosphate, fructose-6-phosphate, and glucose-6-phosphate; (ii) has smaller cells (diameter ca. 13% less); (iii) has fewer thylakoids (ca. 30% less); and (iv) has a more extensive fibrous outer wall layer. Isoprenoid biosynthesis is restored with pentose phosphate cycle substrates plus the recombinant Sll1556 protein in the Δsll1556 supernatant fraction. IPP isomerase activity could not be demonstrated for the purified Sll1556 protein under our in vitro conditions. The reduction of thylakoid area and the effect on outer wall layer components are consistent with an impairment of isoprenoid biosynthesis in the mutant, possibly via hopanoid biosynthesis. Our findings are consistent with an alternate metabolic shunt for biosynthesis of isoprenoids.
Are individuals with mental retardation at high risk for chronic disease?

BACKGROUND AND OBJECTIVES Family physicians are responsible for the health and illness care of individuals with mental retardation (MR) in many community practices. Therefore, it is important to determine the special disease patterns for this group. This study determined if individuals with MR are at increased risk for selected chronic diseases. METHODS We analyzed 366 individuals, living in the community, with a primary diagnosis of MR. The two comparison groups without MR were 427 individual Medicaid recipients and 746 privately insured individuals. RESULTS Individuals with MR had higher rates of neurophysical conditions (eg, seizures, central nervous system conditions, and sensory loss) compared to the other two groups. However, they had lower rates of some chronic conditions and health behaviors (eg, hypertension, migraines/chronic headaches, diabetes, depression or anxiety, obesity, substance abuse, and smoking) compared to other Medicaid and insured patients. CONCLUSIONS Individuals with MR have lower rates of many chronic conditions, compared with other Medicaid recipients. This finding should reduce concerns among family physicians that treatment of this special population involves higher rates of chronic illness.
Phytoremediation of soil and water contaminants

OVERVIEW 1. Phytoremediation of Contaminated Water and Soil RHIZOSPHERE ECOLOGY 2. Rhizosphere Ecology of Xenobiotic-Degrading Microorganisms PHYTOREMEDIATION OF AGROCHEMICALS 3. Aromatic Nitroreduction of Acifluorfen in Soils, Rhizospheres, and Pure Cultures of Rhizobacteria 4. Atrazine Degradation in Pesticide-Contaminated Soils: Phytoremediation Potential 5. Utilization of Plant Material for Remediation of Herbicide-Contaminated Soils 6. Potential of Biostimulation To Enhance Dissipation of Aged Herbicide Residues in Land-Farmed Waste 7. An Integrated Phytoremediation Strategy for Chloroacetamide Herbicides in Soil 8. Ascorbate: A Biomarker of Herbicide Stress in Wetland Plants 9. Degradation of Persistent Herbicides in Riparian Wetlands 10. Phytoremediation of Herbicide-Contaminated Surface Water with Aquatic Plants 11. The Metabolism of Exogenously Provided Atrazine by the Ectomycorrhizal Fungus Hebeloma crustuliniforme and the Host Plant Pinus ponderosa PHYTOREMEDIATION OF INDUSTRIAL CHEMICALS 12. Evaluation of the Use of Vegetation for Reducing the Environmental Impact of Deicing Agents 13. Phytoremediation of Trichloroethylene with Hybrid Poplars 14. Field Study: Grass Remediation for Clay Soil Contaminated with Polycyclic Aromatic Hydrocarbons 15. Benzo(a)pyrene and Hexachlorobiphenyl Contaminated Soil: Phytoremediation Potential 16. Fate of Benzene in Soils Planted with Alfalfa: Uptake, Volatilization, and Degradation 17. Metabolism of Chlorinated Phenols by Lemna gibba, Duckweed 18. Rhizosphere Effects on the Degradation of Pyrene and Anthracene in Soil PHYTOREMEDIATION OF METALS 19. Arabidopsis thaliana as a Model System for Studying Lead Accumulation and Tolerance in Plants 20. Bioremediation of Chromium from Water and Soil by Vascular Aquatic Plants 21. Phytoextraction of Lead from Contaminated Soils 22. Phytoremediation and Reclamation of Soils Contaminated with Radionuclides
Modules in health classifications

In applications, for example in health care, many-valuedness modelled using quantales plays an important role. The paper presents variations of the three chain modules C3 over unitalization of the three chain quantale (C3 is the smallest possible quantale to model many-valuedness), thus, variations of right actions are given. From application point of view, it is then possible to choose suitable modules when modelling, for example, the causalities between disease, intervention and functioning. The effect of drug interaction in presence of multiple diseases, and as affecting functioning, adds to this complexity. Health care communities and professionals comply with a range classifications and terminologies, also including scales to qualify strength or hierarchies of evidence, in the sense of Evidence-Based Medicine (EBM), or interaction, or as related to levels of functioning. Such hierarchies adopted in health care are ad hoc as compared to the potentially algebraic and logical structures of terminologies used as part of clinical decision-making. The notion of ‘evidence’ in EBM would benefit from a logical enrichment. In this paper we show how these hierarchies canonically derive as actions where transitions appear as levels in hierarchies of evidence. In this sense, the Logic-Based Medicine (LBM) view is complementary to EBM, the latter indeed very well known and established, whereas LBM is yet to be recognized more broadly. We will also see how three-valuedness related to health conditions, rather than two-valuedness, is the generator of many-valuedness related to strength of evidence.
The mineral magnetic properties of an annually laminated Holocene lake-sediment sequence in northern Sweden

Detailed mineral magnetic measurements were conducted on a 9000-year varved lake sediment sequence in northern Sweden (Lake Sarsjön). The results demonstrate that the paramagnetic susceptibility reflects the concentration of detrital minerogenic material in the lake sediments, which is controlled to a large extent by the intensity of the spring snow melt. In contrast, the concentration of ferrimagnetic magnetite (reflected by initial magnetic susceptibility and magnetic hysteresis parameters) is positively correlated to the concentration of organic carbon, which is most likely of an autochthonous origin. This magnetite has magnetic properties that are characteristic of stable single-domain magnetite grains produced by magnetotactic bacteria. The paramagnetic susceptibility record clearly points to a climatic excursion in the early Holocene between 6100± 174 bc and 5700± 167 bc, which can be correlated to an d18O excursion (a cold event) in the Greenland ice cores and lake sediments in southern Germany, and also to a short period of increased glacial activity in Scandinavia. The middle Holocene (4000–1760 bc) is characterized by sediment with a low concentration of detrital minerals and a high organic carbon content, whereas the late Holocene (1760 bc–ad 1918) is marked by more frequent and intense periods of detrital sedimentation.
Assaying RNA chaperone activity in vivo using a novel RNA folding trap

In the absence of proteins, RNAs often misfold in vitro due to alternative base pairings which result from the molecule being trapped in inactive conformations. We identify an in vivo folding trap in the T4 phage td gene, caused by nine base pairs between a sequence element in the upstream exon of the td gene and another at the 3′ end of the intron. During translation, the ribosome resolves this interaction; consequently the intron folds correctly and splicing occurs. The introduction of a stop codon upstream of this base pairing prevents resolution of the inactive structure so that splicing cannot proceed. We have used this folding trap to probe for RNA binding proteins which, when overexpressed, either resolve the misfolded structure or impede its formation in vivo. We distinguish between proteins which recognize the intron structure and those which bind non‐specifically and apparently ignore the intron. The first class, e.g. Neurospora crassa CYT‐18, can rescue the exonic trap and intron mutants which cause a structural defect. However, known RNA chaperones such as Escherichia coli StpA and S12 and the HIV protein NCp7, only resolve the exonic trap without suppressing intron mutations. Thus, this structural trap enables detection of RNA chaperone activity in vivo.
A Language-Independent System for Generating Feature Structures from Interlingua Representations

Two main problems in natural language generation are lexical selection and syntactic • structure determination. In interlingua approach to machine translation, determining sentence structures becomes more difficult, especially when the interlingua does not contain any syntactic information, in this paper, a knowledge-based computational model which handles these two problems in interlingua approach is presented. The developed system takes interlingua representations of individual sentences, performs lexical selection, and produces frame-based syntactic structures. The system takes all the information about the target language from knowledge resources, in other words its architecture is language-independent. The implemented system is tested with Turkish through small-sized resources such that its output can be fed into a previously developed tactical generator to produce the final realizations of Turkish sentences.