Miracle-dz/UniFAR-FTUs huggingface dataset:
A Comprehensive Study of Bluetooth Signal Parameters for Localization

We provide an elaborate discussion on Bluetooth signal parameters with respect to localization, whereby we collectively designate all types of Bluetooth specification parameters that are related to signal strength - such as RSSI, Link Quality, Received and Transmit Power Level - as Bluetooth signal, parameters. According to our analysis and experimental results, "RSSI" and "Transmit Power Level" turn out to be poor candidates for localization, while "Link Quality" has its limitations. On the other hand, "Received Power Level" correlates nicely with distance, which makes it the most desirable Bluetooth signal parameter to be used in location systems. We contend that it is vital to choose the appropriate signal parameter in Bluetooth location systems, and we expect our work to provide useful pointers in any future design of such systems. Existing systems can also benefit by adopting the appropriate Bluetooth signal parameter in their systems, and thereby, improve their location accuracy.
Activation of human monocytes by Streptococcus mutans serotype f polysaccharide: immunoglobulin G Fc receptor expression and tumor necrosis factor and interleukin-1 production

Streptococcus mutans serotype f polysaccharide (poly f) was prepared from S. mutans whole cells by autoclaving. The poly f was purified by chromatography on DEAE Trisacryl M and Bio-Gel P100, treated with insoluble pronase, and resubjected to chromatography on DEAE Trisacryl M. Normal human blood monocytes, stimulated in vitro with purified poly f, produced extracellular tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) in a dose-dependent fashion as determined by a heterologous two-site sandwich enzyme-linked immunosorbent assay. Poly f also increased the expression of monocyte cell surface receptors for the Fc part of human immunoglobulin G, activity which is correlated with an increase of the phagocytic activity of the stimulated monocytes. Polymyxin B had no effect on TNF-alpha and IL-1 beta release. Neutralization assays with anti-recombinant human TNF-alpha and anti-recombinant human IL-1 beta immunoglobulin G confirmed the fact that the cytotoxic and mitogenic mediators released by the poly f-stimulated monocytes were mainly TNF-alpha and IL-1 beta.
Edinburgh Artery Study: prevalence of asymptomatic and symptomatic peripheral arterial disease in the general population.

Intermittent claudication has been studied in cardiovascular surveys but limited information is available on asymptomatic peripheral arterial disease. The purpose of this paper is to describe the prevalence of both asymptomatic and symptomatic disease and relation to ischaemic heart disease in the Edinburgh Artery Study. A cross-sectional survey was conducted on an age-stratified sample of men and women aged 55 to 74 years selected from age-sex registers in ten general practices in the city. Arterial disease was assessed in 1592 participants by means of the WHO questionnaire on intermittent claudication and measurement of the ankle brachial systolic pressure index (ABPI) and change in ankle systolic pressure during reactive hyperaemia. The prevalence of intermittent claudication was 4.5% (95% confidence interval (CI): 3.5%-5.5%). Major asymptomatic disease causing a significant impairment of blood flow occurred in 8.0% (95% CI: 6.6%-9.4%). A further 16.6% (95% CI: 14.6%-18.5%) had criteria considered abnormal in clinical practice: 9.0% had ABPI less than 0.9 and 7.6% had reactive hyperaemia pressure reduction greater than 20%. Intermittent claudication was equally common in both sexes. The ABPI and reactive hyperaemia results suggested a slight preponderance of asymptomatic disease in males and were consistent with an increasing prevalence with age and lower social class. Mean ABPI was higher in normal men than women, and was lower in the left leg than the right suggesting a unilateral predisposition to disease. Subjects with major asymptomatic disease had more evidence of ischaemic heart disease than in the normal population (relative risk (RR) 1.6; 95% CI: 1.3-1.9). (ABSTRACT TRUNCATED AT 250 WORDS)
Directing Place Representation in the Hippocampus

Theoretical models of rodent navigation consider location information and directional heading to be essential. Indeed, the existence of location-selective 'place cells' and orientation-selective 'head direction cells' is well documented. Different models suggest different forms of interaction between information about location and heading direction. However, until recently, there were no clear empirical data that could be used to distinguish the different models in terms of the nature of the integration of location and directional heading information. Recently, Leutgeb et al. provided evidence that head direction and place signals coexist within the CA1 region of hippocampus, and that the head direction signals are likely to be generated by a subpopulation of interneurons. This finding opens up new possibilities for clarifying current models and for developing biologically plausible theories of synaptic interactions between location and head direction codes. In this paper, we first present the issue concerning the nature of the interaction between location and head direction signals, followed by a selective review of place and head direction cell research. The finding of Leutgeb et al. is then summarized, and its implications for current models are discussed. Finally, a view is presented that considers place fields to be a product not only of (external and internal) sensory input, but also of non-spatial variables such as motivation and responses. The finding of Leutgeb et al. and many earlier anatomical studies suggest that hippocampal head direction, motivation and response information may be represented by the interneuron population. Thus, these factors may have strong impact on the location codes of hippocampal pyramidal neurons. Their influence may further define the behavioral context of the current spatial environment.
Multi-modal Aggregation for Video Classification

In this paper, we present a solution to Large-Scale Video Classification Challenge (LSVC2017) [1] that ranked the 1st place. We focused on a variety of modalities that cover visual, motion and audio. Also, we visualized the aggregation process to better understand how each modality takes effect. Among the extracted modalities, we found Temporal-Spatial features calculated by 3D convolution quite promising that greatly improved the performance. We attained the official metric mAP 0.8741 on the testing set with the ensemble model.
O R I G I N a L I N V E S T I G a T I O N Open Access High Glucose Mediates Endothelial-to-chondrocyte Transition in Human Aortic Endothelial Cells

Background: Vascular calcification is one of the common complications in diabetes mellitus. Many studies have shown that high glucose (HG) caused cardiovascular calcification, but its underlying mechanism is not fully understood. Recently, medial calcification has been most commonly described in the vessels of patients with diabetes. Chondrocytes were involved in the medial calcification. Recent studies have shown that the conversion into mesenchymal stem cells (MSCs) via the endothelial-to-mesenchymal transition (EndMT) could be triggered in chondrocytes. Our previous research has indicated that HG induced EndMT in human aortic endothelial cells (HAECs). Therefore, we addressed the question of whether HG-induced EndMT could be transitioned into MSCs and differentiated into chondrocytes.
Sinusoidal time-modulated uniform circular array for generating orbital angular momentum modes

Time Modulated Uniform Circular Arrays (TMUCA) can produce Orbital Angular Momentum (OAM) modes using relatively inexpensive hardware. For enhanced spectral efficiency in line-of-sight links, it is desirable to produce multiple OAM modes simultaneously. TMUCA typically suffer from leakage of energy into all the other available OAM modes, which is undesirable because it increases crosstalk between the channels. This paper proposes a modified approach to TMUCA that overcomes the energy-leakage limitation. We adopt a time-modulation scheme that can be viewed as similar to intermediate frequency beamforming, although we do not use it for its beam-forming properties. Here, only the fundamental harmonic of the time-switching signal is applied to the system, eliminating unwanted spectral and spatial mode leakage in the ideal case. Simulations are presented in support of our proposal.
Approximating unique games

The UNIQUE GAMES problem is the following: we are given a graph <i>G</i> = (<i>V, E</i>), with each edge <i>e</i> = (<i>u, v</i>) having a weight <i>w</i><inf><i>e</i></inf> and a permutation π<inf><i>uv</i></inf> on [<i>k</i>]. The objective is to find a labeling of each vertex <i>u</i> with a label <i>f</i><inf><i>u</i></inf> ∈ [<i>k</i>] to minimize the weight of unsatisfied edges---where an edge (<i>u, v</i>) is <i>satisfied</i> if <i>f</i><inf><i>v</i></inf> = π<inf><i>uv</i></inf>(<i>f</i><inf><i>u</i></inf>). The <i>Unique Games Conjecture</i> of Khot [8] essentially says that for each ε > 0, there is a <i>k</i> such that it is NP-hard to distinguish instances of Unique games with (1-ε) satisfiable edges from those with only ε satisfiable edges. Several hardness results have recently been proved based on this assumption, including optimal ones for Max-Cut, Vertex-Cover and other problems, making it an important challenge to prove or refute the conjecture.In this paper, we give an <i>O</i>(log <i>n</i>)-approximation algorithm for the problem of minimizing the number of unsatisfied edges in any Unique game. Previous results of Khot [8] and Trevisan [12] imply that if the optimal solution has OPT = ε<i>m</i> unsatisfied edges, semidefinite relaxations of the problem could give labelings with min {<i>k</i><sup>2</sup>ε<sup>1/5</sup>, (ε log <i>n</i>)<sup>1/2</sup>}<i>m</i> unsatisfied edges. In this paper we show how to round a LP relaxation to get an <i>O</i>(log <i>n</i>)-approximation to the problem; i.e., to find a labeling with only <i>O</i>(ε<i>m</i> log <i>n</i>) = <i>O</i>(OPT log <i>n</i>) unsatisfied edges.
The Role of Oxidoreductases in Determining the Function of the Neisserial Lipid A Phosphoethanolamine Transferase Required for Resistance to Polymyxin

The decoration of the lipid A headgroups of the lipooligosaccharide (LOS) by the LOS phosphoethanolamine (PEA) transferase (LptA) in Neisseria spp. is central for resistance to polymyxin. The structure of the globular domain of LptA shows that the protein has five disulphide bonds, indicating that it is a potential substrate of the protein oxidation pathway in the bacterial periplasm. When neisserial LptA was expressed in Escherichia coli in the presence of the oxidoreductase, EcDsbA, polymyxin resistance increased 30-fold. LptA decorated one position of the E. coli lipid A headgroups with PEA. In the absence of the EcDsbA, LptA was degraded in E. coli. Neisseria spp. express three oxidoreductases, DsbA1, DsbA2 and DsbA3, each of which appear to donate disulphide bonds to different targets. Inactivation of each oxidoreductase in N. meningitidis enhanced sensitivity to polymyxin with combinatorial mutants displaying an additive increase in sensitivity to polymyxin, indicating that the oxidoreductases were required for multiple pathways leading to polymyxin resistance. Correlates were sought between polymyxin sensitivity, LptA stability or activity and the presence of each of the neisserial oxidoreductases. Only meningococcal mutants lacking DsbA3 had a measurable decrease in the amount of PEA decoration on lipid A headgroups implying that LptA stability was supported by the presence of DsbA3 but did not require DsbA1/2 even though these oxidoreductases could oxidise the protein. This is the first indication that DsbA3 acts as an oxidoreductase in vivo and that multiple oxidoreductases may be involved in oxidising the one target in N. meningitidis. In conclusion, LptA is stabilised by disulphide bonds within the protein. This effect was more pronounced when neisserial LptA was expressed in E. coli than in N. meningitidis and may reflect that other factors in the neisserial periplasm have a role in LptA stability.
Foraging Ecology of Lactating Steller Sea Lions (Eumetopias jubatus) at Lovushki Island, Russia

A key objective of the National Marine Fisheries Service recovery plan for Steller sea lions (SSL – Eumetopias jubatus) is to protect critical habitats. Doing so relies in part on knowledge of SSL ecology based on time-depth data, at-sea dive locations and post-trip dietary analyses. I used data from animal-borne video and data recorders (VDRs) attached to lactating SSL at Lovushki Island, Russia to improve our knowledge by: 1) classifying dives based on three-dimensional swim paths and foraging success, 2) quantifying rates at which prey were encountered and consumed, and 3) testing whether a giving up rule, shown to be applicable to phocids, could similarly benefit SSL. I identified five dive types: shallow and deep foraging dives, opportunistic foraging dives, a group of unique dives with no consistent behaviors, and non-foraging dives. I found that discrimination between foraging and non-foraging dives was possible with time-depth data alone, but relied on the assumption that time spent swimming horizontally between the descent and ascent represented swimming at the seabed. I also concluded that SSL at Lovushki were consuming enough prey to satisfy their estimated nutritional requirements. To determine if lactating SSL at Lovushki Island could improve foraging success by incorporating a giving up rule into their foraging strategy I: 1) identified how dive duration varied according to foraging success and 2) constructed a simulation model to simulate the foraging behaviors and habitats of SSL. SSL did not appear to employ a
The Mitogen-Activated Protein Kinase Pathway Mediates Estrogen Neuroprotection after Glutamate Toxicity in Primary Cortical Neurons

Pharmacological and biochemical approaches were used to elucidate the involvement of growth factor signaling pathways mediating estrogen neuroprotection in primary cortical neurons after glutamate excitotoxicity. We addressed the activation of mitogen-activated protein kinase (MAPK) signaling pathways, which are activated by growth factors such as nerve growth factor (NGF). Inhibition of MAPK signaling with the MAPK kinase inhibitor PD98059 blocks both NGF and estrogen neuroprotection in these neurons. These results correlate with a rapid and sustained increase in MAPK activity within 30 min of estrogen exposure. The involvement of signaling molecules upstream from MAPK was also examined to determine whether activation of MAPK by estrogen is mediated by tyrosine kinase activity. Estrogen produces a rapid, transient activation of src-family tyrosine kinases and tyrosine phosphorylation of p21ras-guanine nucleotide activating protein. Effects of estrogen on neuroprotection, as well as rapid activation of tyrosine kinase and MAPK activity, are blocked by the anti-estrogen ICI 182,780. This provides evidence that activation of the MAPK pathway by estrogen participates in mediating neuroprotection via an estrogen receptor. These results describe a novel mechanism by which cytoplasmic actions of the estrogen receptor may activate the MAPK pathway, thus broadening the understanding of effects of estrogen in neurons.
Reflex peripheral vasoconstriction is diminished in older men.

The purpose of this study was to compare reflex control of limb blood flow in healthy young (Y; 26 +/- 2 yr) and older (O;61 +/- 2 yr) men during whole body cooling under resting conditions. To better isolate the effect of chronological age, the two age groups (n = 6 per group) were closely matched for maximal oxygen uptake, body surface area, skinfold thickness, and fat-free weight. Subjects sat in an environmentally controlled chamber clad in standardized (0.6-clo) light cotton clothing at a dry-bulb temperature (Tdb) of 28 degrees C. After 30 min, Tdb was decreased by 2 degrees C every 5 min until Tdb = 10 degrees C, where it was held constant for the remainder of the 120-min session. Esophageal and mean skin temperatures were monitored continuously. Forearm blood flow (FBF) was measured every 5 min by venous occlusion plethysmography by using a mercury-in-Silastic strain gauge while arm temperature between the wrist and elbow was clamped at 37.2 +/- 0.1 degrees C by localized warm air heating. In this way, limb vasoconstriction was driven solely by thermoregulatory reflexes and not by direct effects of localized cooling. Mean skin temperature decreased at a similar rate and to a similar extent (by approximately 6 degrees C over a 2-h period) in both age groups, whereas esophageal temperature was relatively unaffected. In response to the local heating, the Y group maintained a significantly higher FBF than did the O group during the initial 30 min but decreased FBF during the cooling phase at a greater rate and to a greater extent than did the O group, leading to a significantly lower FBF during the final 30 min (at Tdb = 10 degrees C). Because there was no age difference in the mean arterial pressure response, similar effects of age were seen on forearm vascular conductance (FBF/mean arterial pressure). It was concluded that older men have a diminished reflex limb vasoconstrictor response to skin cooling. Furthermore, this difference in control of peripheral blood flow appears to be related to age per se; i.e., it is not a reflection of age-related differences in maximal oxygen uptake or body composition.
Fair queueing with service envelopes (FQSE): a cousin-fair hierarchical scheduler for subscriber access networks

In this paper, we propose and investigate the characteristics of a fair queueing with service envelopes (FQSE) algorithm-a hierarchical fair-share scheduling algorithm for access networks based on a remote scheduling system such as Ethernet passive optical networks (EPON) or cable TV network. FQSE is designed to overcome the limiting factors of a typical remote scheduling system such as large control-plane delay, limited control-plane bandwidth, and significant queue switch-over overhead. The algorithm is based on a concept of service envelope-a function representing the fair allocation of resources based on a global network condition called satisfiability parameter (SP). We define properties of cousin-fairness and sibling-fairness and show the FQSE to be cousin-fair. FQSE is unique in that it is the only hierarchical algorithm that is simultaneously cousin-fair. Furthermore, we show the necessary techniques to adapt FQSE to variable-sized packet-based networks. We analyze FQSE performance in EPON serving 1024 independent queues and demonstrate FQSE's ability to provide guaranteed bandwidth to each queue and to share the excess bandwidth fairly.
Towards an Implementation Theory via a Game Logic Approach

Recently, the general approach of Game Theory, which is to find the set of outcomes (the equilibria) of a solution concept in a game, has been modeled by means of Game Logics, in which a game and a solution concept are related to models and formulas of a Game Logic. Thus, the general problem can be stated as a model-checking problem. Moreover, the set of solutions can be found automatically by using model-checkers of the respective Game Logic. The implementation problem in Game Theory focus on the inverse problem, i.e., finding a game that yields a given set of outcomes as equilibria of a solution concept. In this work, we relate the implementation problem to a model checking problem of an adequate Game Logic. Specifically, we illustrate the relationship between the implementation problem of extensive games with perfect information and the model checking problem of GAL (Game Analysis Logic). As a consequence, we can benefit of the use of model-checkers in order to solve the implementation problem as well. It is worth mentioning that the approach used in this article seems to be adequate for other Game Logics as well.
Middle to late Holocene sedimentation dynamics and paleoclimatic conditions in the Lake Ulaan basin, southern Mongolia

This study presents a reconstruction of the middle to late Holocene sedimentation dynamics and paleoclimatic implications in Lake Ulaan, southern Mongolia for the first time. The dynamics is inferred from weathering intensity, Accelerator Mass Spectrophotometry (AMS) radiocarbon dating and estimated sedimentation rates. Result shows that a higher sedimentation rate of 4.6 cm.kyr‑¹ between 2.7 and 6.0 cal kyr BP and a lower sedimentation rate of 1.6-1.8 cm.kyr‑1 after 2.7-3.2 cal kyr BP are associated with a climatic shift from humid in the middle Holocene to arid in the late Holocene within the Lake Ulaan basin. This result from the Lake Ulaan basin in southern Mongolia correlates with the middle and late Holocene climatic records reconstructed from other lakes in Mongolia and Central Asia. Further investigation of lacustrine sedimentary sequences and more age data from Lake Ulaan are still needed to constrain better the Holocene sedimentation history in southern Mongolia and Central Asia.
Synthesis and Antifungal Activity of Some Organotin(IV) Carboxylates

Six diorganotin(IV) carboxylates prepared by reacting diorganotin(IV) dichlorides with the respective silver carboxylate have been tested for antifungal activity against Aspergillus. niger, Aspergilluus flavus and Pencillium. citrinum in Sabourand dextrose broth. The compounds generally exhibit greater fungitoxicity than the diorganotin(IV) dichlorides and the carboxylic acids from which they were synthesized. In keeping with the generally accepted notion that the organotin moiety plays an important role in deciding the antifungal activity of an organotin compound, the diphenyltin(IV) compounds were more active than their di-n-butyltin(IV) analogues. However, the order of increasing fungitoxicity of the compounds parallels that of the uncomplexed carboxylic acids. The implications of the results are discussed.
Prognostication of Residual Life and Latent Damage Assessment in Lead-Free Electronics Under Thermomechanical Loads

Requirements for system availability for ultrahigh reliability electronic systems such as airborne and space electronic systems are driving the need for advanced health monitoring techniques for the early detection of the onset of damage. Aerospace electronic systems usually face a very harsh environment, requiring them to survive the high strain rates, e.g., during launch and reentry, and thermal environments, including extremely low and high temperatures. Traditional health monitoring methodologies have relied on reactive methods of failure detection often providing little or no insight into the remaining useful life of the system. In this paper, a mathematical approach for the interrogation of the system state under cyclic thermomechanical stresses has been developed for six different lead-free solder alloy systems. Data have been collected for leading indicators of failure for alloy systems, including Sn3Ag0.5Cu, Sn0.3Ag0. 7Cu, Sn1Ag0.5Cu, Sn0.3Ag0. 5Cu0.1Bi, Sn0.2Ag0. 5Cu0.1Bi0. 1Ni, and 96.5 Sn3.5Ag second-level interconnects under the application of cyclic thermomechanical loads. The methodology presented resides in the prefailure space of the system in which no macroindicators such as cracks or delamination exist. Systems subjected to thermomechanical damage have been interrogated for the system state and the computed damage state correlated with the known imposed damage. The approach involves the use of condition monitoring devices which can be interrogated for damage proxies at finite time intervals. The interrogation techniques are based on the derivation of damage proxies and system prior-damage-based nonlinear least square methods, including the Levenberg-Marquardt algorithm. The system's residual life is computed based on residual-life computation algorithms.