Miracle-dz/UniFAR-FTUs huggingface dataset:
Neutral Hydrogen Clouds Near Early-Type Dwarf Galaxies of the Local Group

Parkes neutral hydrogen 21 cm line (H I) observations of the surroundings of nine early-type Local Group dwarfs are presented. We detected numerous H I clouds in the general direction of those dwarfs, and these clouds are often offset from the optical center of the galaxies. Although all the observed dwarfs, except Antlia, occupy phase-space regions where the high-velocity cloud (HVC) density is well above average, the measured offsets are smaller than one would expect from a fully random cloud distribution. Possible association is detected for 11 of the 16 investigated clouds, while for two galaxies, Sextans and Leo I, no H I was detected. The galaxies in which H I clouds were found not to coincide with the optical yet have a significant probability of being associated are the Sculptor dwarf, Tucana, LGS 3, Cetus, and Fornax. If the clouds are indeed associated, these galaxies have H I masses of M = 2 × 105, 2 × 106, 7 × 105, 7 × 105, and 1 × 105 M⊙, respectively. However, neither ram pressure nor tidal stripping can easily explain the offsets. In some cases, large offsets are found where ram pressure should be the least effective.
Old age and anti-cytomegalovirus immunity are associated with altered T-cell reconstitution in HIV-1-infected patients

Objective and design:Increasing evidence supports a parallel between HIV-1 infection and immune aging, which is particularly apparent with common changes in naive versus memory T-cell proportions. Here, we aimed at refining the value of common T-cell-associated markers of immunosenescence during HIV disease progression or aging, and at exploring further the impact in this context of old age as well as cytomegalovirus (CMV) co-infection, which is predominant in HIV-1-infected individuals. Methods:Frequencies of naive or CD57+ memory T cells as well as the magnitude of CMV-pp65 T cells were measured in HIV-1-infected patients grouped according to disease progression status, treatment and age. Results:Our results indicate that the decline in naive T-cell levels rather than the accumulation of CD57+ senescent T cells identifies best the premature development of an immunosenescence phenotype with HIV disease progression. Moreover, advanced age or mounting of strong CMV-specific responses impact independently on CD4+ T-cell counts and recovery with antiretroviral therapy. Conclusions:The present findings indicate that HIV-1 infection amplifies the effect of age on naive T-cell levels, and highlight the constraint on the capacity of treated patients to reconstitute their CD4+ T-cell compartment due to age and CMV co-infection.
A REVIEW OF PROBABILISTIC GRAPH MODELS FOR FEATURE SELECTION WITH APPLICATIONS IN ECONOMIC AND FINANCIAL TIME SERIES FORECASTING

In every field of life, people are interested to be able to forecast future. A number of techniques are available to predict and forecasting upto a certain level of accuracy. Many techniques involve statistical tools and techniques for forecasting, modeling and control. Use of statistical techniques is growing with time and new techniques are being developed very rapidly. Especially in the field of economics and finance, the estimation and forecasting of economic and financial indicators play a vital role in decision making. Many models are developed in the last 2 decades to get better accuracy and efficiency in time series analysis and still there is a scope of learning and getting betterment in this field is available. In this research we have reviewed probability graphs, directed acyclic graphs, Bayesian networks, feature selection algorithms and Markov blankets for time series forecasting on the economic and financial problems (like stock exchange forecasting, multi-objective business risk analysis, consumers’ analysis, portfolio optimization, credit scoring etc). This is a new dimension for adaptive modeling techniques in economics and finance modeling.
High-assurance system support through 3-D integration

Abstract : While hardware resources, in the form of both transistors and full microprocessor cores, are now fairly abundant, economic factors continue to prevent the integration into commodity parts of specialized hardware mechanisms required for secure processing. Multi-core processors, due to their wide adoption, impressive performance, and low cost, are very attractive platforms for computation. Unfortunately, highly secure processing of sensitive information on such platforms is extremely difficult to achieve due to extensive resource sharing and the lack of strong security primitives. In this paper we propose that commodity integrated circuits, with some very minor modifications, could be enhanced with a separate silicon layer used to enforce strong isolation, reference monitoring, and other useful security properties. A separate layer, stacked using 3-D integration, allows us to decouple the function and economics of high assurance policy enforcement mechanisms from the underlying high-performance computing hardware. We describe 3-D integration, how the host layer may be modified, and as our working example, we show how the problem of cache-based side channels can be addressed by re-routing signals from the computation layer through a cache manager in the control layer.
Efficient Wide-Band FIR LTI Systems Derived Via Multi-Rate Techniques and Sparse Bandpass Filters

This correspondence introduces efficient realizations of wide-band LTI systems. They are single-rate realizations but derived via multi-rate techniques and sparse bandpass filters. The realizations target mid-band systems with narrow don't-care bands near the zero and Nyquist frequencies. Design examples for fractional-order differentiators demonstrate substantial complexity savings as compared to the conventional minimax-optimal direct-form realizations.
Design of an Inductive Contactless Power System for Multiple Users

The technique of inductive contactless energy transfer (CET) has found its application in specific industrial applications where an (air) gap between energy source and load is preferable or even required. A relative new application area of CET is where CET is part of a general energy distribution network. As an example, electrical sockets might give problems in bathrooms for safety reasons: CET provides a solution because of inherent electrical isolation between source (grid) and loads (e.g. hair dryer or electrical shaver). For such application this paper reports on the design of a contactless power system that is able to supply to multiple users simultaneously, analogously to the regular plug-and-socket network. The proposed contactless system consists of a special energy supply cable where clamps (each maximum 240 W) can be mounted on at arbitrary locations along the cable while electrical isolation is maintained between cable and clamps. Result is a supply cable design and a prototype with 2 clamps, which are compared by means of analytical calculations, simulations and experimental results
Etsrp/Etv2 Is Directly Regulated by Foxc1a/b in the Zebrafish Angioblast

Rationale: Endothelial cells are developmentally derived from angioblasts specified in the mesodermal germ cell layer. The transcription factor etsrp/etv2 is at the top of the known genetic hierarchy for angioblast development. The transcriptional events that induce etsrp expression and angioblast specification are not well understood. Objective: We generated etsrp:gfp transgenic zebrafish and used them to identify regulatory regions and transcription factors critical for etsrp expression and angioblast specification from mesoderm. Methods and Results: To investigate the mechanisms that initiate angioblast cell transcription during embryogenesis, we have performed promoter analysis of the etsrp locus in zebrafish. We describe three enhancer elements sufficient for endothelial gene expression when place in front of a heterologous promoter. The deletion of all 3 regulatory regions led to a near complete loss of endothelial expression from the etsrp promoter. One of the enhancers, located 2.3 kb upstream of etsrp contains a consensus FOX binding site that binds Foxc1a and Foxc1b in vitro by EMSA and in vivo using ChIP. Combined knockdown of foxc1a/b, using morpholinos, led to a significant decrease in etsrp expression at early developmental stages as measured by quantitative reverse transcriptase–polymerase chain reaction and in situ hybridization. Decreased expression of primitive erythrocyte genes scl and gata1 was also observed, whereas pronephric gene pax2a was relatively normal in expression level and pattern. Conclusions: These findings identify mesodermal foxc1a/b as a direct upstream regulator of etsrp in angioblasts. This establishes a new molecular link in the process of mesoderm specification into angioblast.
Determination of Advanced Glycation End Products in Serum by Fluorescence Spectroscopy and Competitive ELISA

Recent studies suggest that advanced glycation endproducts play an important role in cardiovascular complications of ageing, diabetes and end-stage renal failure. Since highly elevated levels of advanced glycation endproducts are present in serum of patients on maintenance haemodialysis, an accurate and rapid assay for their determination would be useful. This would be particularly valuable for monitoring the removal of advanced glycation endproducts by novel dialysis membranes, as well as the effect of new drugs for the inhibition of their formation. Measurement of advanced glycation endproducts in serum was performed by two competitive ELISAs, using a monoclonal antibody directed against imidazolone, an advanced glycation endproduct formed by the reaction of arginine with 3-deoxyglucosone, and a polyclonal antibody directed against keyhole limpet haemocyanin-advanced glycation endproduct, as well as by quantitative fluorescence spectroscopy. Each of the assays showed significant differences between the controls and the maintenance haemodialysis patients. Advanced glycation endproduct levels determined by each of the ELISAs correlated with total and protein-bound fluorescence, but not with each other, suggesting a variable distribution of advanced glycation endproducts on serum proteins among the maintenance haemodialysis patients.
The Spatial Organization of Long-Term Synaptic Plasticity at the Input Stage of Cerebellum

The spatial organization of long-term synaptic plasticity [long-term potentiation (LTP) and long-term depression (LTD)] is supposed to play a critical role for distributed signal processing in neuronal networks, but its nature remains undetermined in most central circuits. By using multielectrode array recordings, we have reconstructed activation maps of the granular layer in cerebellar slices. LTP and LTD induced by theta-burst stimulation appeared in patches organized in such a way that, on average, LTP was surrounded by LTD. The sign of long-term synaptic plasticity in a given granular layer region was directly correlated with excitation and inversely correlated with inhibition: the most active areas tended to generate LTP, whereas the least active areas tended to generate LTD. Plasticity was almost entirely prevented by application of the NMDA receptor blocker, APV. This suggests that synaptic inhibition, through a control of membrane depolarization, effectively regulates NMDA channel unblock, postsynaptic calcium entry, and the induction of bidirectional synaptic plasticity at the mossy fiber–granule cell relay (Gall et al., 2005). By this mechanism, LTP and LTD could regulate the geometry and contrast of network computations, preprocessing the mossy fiber input to be conveyed to Purkinje cells and molecular layer interneurons.
Relación entre el procesamiento sensorial y la severidad de la sintomatología en una muestra de niños con TEA

The new DSM-5 criteria include the alterations of sensory perception as a new diagnostic criterion to consider in the ASD population. Considering the inclusion of this new approach, the purpose of this study is to compare the features of sensory processing among a group of children (from 5 to 8 years old) with and without ASD. In addition to this, in the case of the ASD group, possible relationships between the sensory processing and the severity of symptoms, assessed by the GARS-2, are analyzed. To do this, the parents of 84 children (41 with ASD diagnosis and 43 with typical development), reported their perception about their children’s sensory processing. The results show significant differences between both groups in all subscales assessing sensory processing. Besides this, in the case of the ASD group, sensory processing characteristics are significantly related to the severity of autistic symptoms. These results show that children with ASD have a different sensory processing to children without ASD. The evaluation of the sensory profile of this particular population should be a prerequisite, since it would allow a better understanding of the disorder and it would also provide the possibility to implement therapeutic measures tailored to the particular needs of each individual.
Establishing Human Personality Metrics for Adaptable Robots During Learning Tasks

This paper describes our ongoing research effort to explore how personality types factor into HRI; in particular, the degree of patience a person has when teaching an error-prone robot in a learning from demonstration setting. Our goal is to establish personality metrics that will ultimately allow for the design of algorithms that automatically tune robot behavior to best suit user preferences based on personality.
Exploring the Problem-Finding and Problem-Solving Approach for Designing Organizations

An emerging problem-finding and problem-solving approach suggests that management's discovering problems to solve, opportunities to seize, and challenges to respond to, are vital to organizations. This paper explores the extent to which the problem-finding and problem-solving approach can provide a foundation for joining the capabilities, dynamic capabilities, and governance perspectives as a way to help scholars and practitioners to coherently design organizations from the perspective of design science. The problem-finding and problem-solving approach offers a unit of analysis and a set of behavioral assumptions that enable us to address open questions within the extant literature and to propose new questions in management research.
DISEÑO DE UN PROYECTO EDUCATIVO: LAS RELACIONES INTERGENERACIONALES ENTRE FAMILIA-NIÑOS/AS PARA EL DESARROLLO PSICOLOGICO Y CURRICULAR EN EDUCACIÓN INFANTIL

In this paper it is analyzed the importance that there have the members of the familiar unit, from the last generation up to the first generation -that is to say, from the parents including brothers, sisters, cousins, uncles, aunts. up to the grandparents in the psychological development of children at a cognitive, social, psychomotor and affective level and in the curriculum development. That is why the starting point is bibliographical review on the definition of the term family, the different typologies of family, the familiar structures, the roles, the affection, the educational styles and finally the social relations. This provides the knowledge needed to understand more easily the familiar situations that are present nowadays in our society and it provide solutions so that children can improve and power their learning and development. Besides, it is elaborated a Program of Intervention from the classroom, where the basic objective is to promote the social relations of our students with their family members in order to favor and to give rise to the globalizing development of all the aspects of the pupils, even to promote the development and the well-being of the members of the family.
Splicing factor SF3a60 is the mammalian homologue of PRP9 of S.cerevisiae: the conserved zinc finger-like motif is functionally exchangeable in vivo.

A cDNA encoding the 60 kDa subunit of mammalian splicing factor SF3a has been isolated. The deduced protein sequence reveals a 30% identity to the PRP9 splicing protein of the yeast S.cerevisiae. The highest homology is present in a zinc finger-like region in the C-terminal domain of both proteins. The PRP9 zinc finger-like motif has been replaced by the equivalent region of mammalian SF3a60. The chimeric protein rescues the temperature-sensitive phenotype of the prp9-1 mutant strain demonstrating that not only the structure but also the function of this domain has been conserved during evolution.
Cascade Control for Telerobotic Systems Serving Space Medicine

Abstract Long distance teleoperation formulates a current control problem task yet to be solved, primarily due to the difficulty to compensate for signal latency. Predictive and model-based control can only give satisfying results if proper description of the system's behavior is provided. The interdisciplinary field of telesurgery has become a focal point of technology-extended medicine, where master–slave type control over large distances poses significant challenges. Innovative solutions are required to deal with the modeling human teleoperation and varying communication quality parameters. In this paper, we investigate the feasibility a more straight-forward, classical control solution based on Kessler's Extended Symmetrical Method, formulated in a cascade control approach to tackle the problems caused by latency and uncertainties in a modeled telesurgical robot system.
Application of polyunsaturated fatty acids in internal medicine: beyond the established cardiovascular effects

n-3 Polyunsaturated fatty acids (PUFAs) are organic acids, essential for mammals, whose deficiency is associated with different diseases. The American Heart Association recommends that all adults increase food-derived n-3 PUFA intake and also suggests that patients with documented coronary heart disease consume approximately 1 g of eicosapentaenoic acid and docosahexaenoic acid per day. However, recent evidence broadens their potential application to many other health disorders directly or indirectly associated with cardiovascular disease risk such as rheumatological diseases, mood depression, chronic kidney disease, chronic inflammatory lung diseases and others. These effects seem to be largely dependent on the dosages employed and on the characteristics of the selected patients. The cardiometabolic effects of PUFAs have been largely reviewed elsewhere, so the aim of our review is to point out the potential usefulness of such drugs with pleiotropic effects in the management of the actual typical aging patient, with co-morbidities and multidrug therapies.
Interactive image retrieval by query fusion

The use of low-level visual features such as colour and shape in content-based image retrieval system leads to several ambiguities. Specifically, due to the many-to-many mapping between the low-level feature space and high-level user concepts, a conceptual user query may not be modelled as a single point in the feature space. Furthermore, conceptually similar images may not fall close to each other in the low-level feature space. This work addresses these issues by proposing an interactive technique, query feedback. This method employs user input to represent a high-level conceptual query as various points in the low-level space. Thus, similarity to a given conceptual query is obtained as the fusion of several low-level representations in the feature space.
Deletion of a Small Consensus Region at 6q15, Including the MAP3K7 Gene, Is Significantly Associated with High-Grade Prostate Cancers

Purpose: Chromosome 6q14-21 is commonly deleted in prostate cancers, occurring in ∼22% of all tumors and ∼40% of metastatic tumors. However, candidate prostate tumor suppressor genes in this region have not been identified, in part due to the large and broad nature of the deleted region implicated in previous studies. Experimental Design: We first used high-resolution Affymetrix single nucleotide polymorphism arrays to examine DNA from malignant and matched nonmalignant cells from 55 prostate cancer patients. We identified a small consensus region on 6q14-21 and evaluated the deletion status within the region among additional 40 tumors and normal pairs using quantitative PCR and fluorescence in situ hybridization. We finally tested the association between the deletion and Gleason score using the Fisher's exact test. Results: Tumors with small, interstitial deletions at 6q14-21 defined an 817-kb consensus region that is affected in 20 of 21 tumors. The MAP3K7 gene is one of five genes located in this region. In total, MAP3K7 was deleted in 32% of 95 tumors. Importantly, deletion of MAP3K7 was highly associated with higher-grade disease, occurring in 61% of tumors with Gleason score ≥8 compared with only 22% of tumors with Gleason score ≤7. The difference was highly significant (P = 0.001). Conclusion: Our study provides strong evidence for the first time that a small deletion at 6q15, including the MAP3K7 gene and four other genes, is associated with high-grade prostate cancers. Although the deletion may be a marker for high-grade prostate cancer, additional studies are needed to understand its molecular mechanisms.
Understanding query interfaces by statistical parsing

Users submit queries to an online database via its query interface. Query interface parsing, which is important for many applications, understands the query capabilities of a query interface. Since most query interfaces are organized hierarchically, we present a novel query interface parsing method, StatParser (Statistical Parser), to automatically extract the hierarchical query capabilities of query interfaces. StatParser automatically learns from a set of parsed query interfaces and parses new query interfaces. StatParser starts from a small grammar and enhances the grammar with a set of probabilities learned from parsed query interfaces under the maximum-entropy principle. Given a new query interface, the probability-enhanced grammar identifies the parse tree with the largest global probability to be the query capabilities of the query interface. Experimental results show that StatParser very accurately extracts the query capabilities and can effectively overcome the problems of existing query interface parsers.
Observer-based indirect speed control for induction machines

In this paper, we present a strategy for the design of an observer-based indirect speed control for induction motors. We first derive a reduced (3rd) order complex differential model for induction motors using the α - β model. For the sake of simplicity, we use this new formulation of the induction motor model as basis for the design of observer-based control methodology. Next, we design an indirect torque controller giving rise to an indirect way of controlling the speed of the machine. Then, as the controller requires the measurements of the rotor fluxes, we synthesise a rotor flux observer which facilitates the implementation of the torque (and speed) controller. Consequently, an observer-based indirect speed controller is essentially designed. The validity of the proposed methodology is assessed via simulation using Matlab/Simulink software package.