Miracle-dz/UniFAR-FTUs huggingface dataset:
Industrial potential of carotenoid pigments from microalgae: Current trends and future prospects

Abstract Microalgae are rich source of various bioactive molecules such as carotenoids, lipids, fatty acids, hydrocarbons, proteins, carbohydrates, amino acids, etc. and in recent Years carotenoids from algae gained commercial recognition in the global market for food and cosmeceutical applications. However, the production of carotenoids from algae is not yet fully cost effective to compete with synthetic ones. In this context the present review examines the technologies/methods in relation to mass production of algae, cell harvesting for extraction of carotenoids, optimizing extraction methods etc. Research studies from different microalgal species such as Spirulina platensis, Haematococcus pluvialis, Dunaliella salina, Chlorella sps. , Nannochloropsis sps. , Scenedesmus sps. , Chlorococcum sps. , Botryococcus braunii and Diatoms in relation to carotenoid content, chemical structure, extraction and processing of carotenoids are discussed. Further these carotenoid pigments, are useful in various health applications and their use in food, feed, nutraceutical, pharmaceutical and cosmeceutical industries was briefly touched upon. The commercial value of algal carotenoids has also been discussed in this review. Possible recommendations for future research studies are proposed.
Interdisciplinary Risk Management in the Treatment of Multiple Sclerosis.

BACKGROUND Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system. There are at least 150 000 persons with MS in Germany. Recent years have seen the approval of new drugs against. METHODS This article is based on pertinent literature retrieved by a selective search in PubMed as well as on documentation of relevant risks and adverse effects in "red hand letters" (information bulletins from pharmaceutical companies to physicians about adverse drug effects) and elsewhere, along with data provided by the German Multiple Sclerosis Competence Network. RESULTS In recent years, there have been major advances enabling better, more individualized treatment of patients with MS. Physicians must, however, give due consideration to potentially severe or even life-threatening adverse drug effects. These can include, for example, transaminase elevation (hepatotoxicity), cardio- and nephrotoxicity, or lympho- and leukopenia with a variable risk of infection. Among patients taking natalizumab, the cumulative risk of developing progressive multifocal leukencephalopathy (PML) may be 1:100 or higher, depending on the individual risk profile. Rare cases of PML have also been seen under treatment with fingolimod and dimethyl fumarate. Moreover, any type of immunosuppressive treatment can, at least theoretically, increase the risk of malignant disease. Secondary autoimmune diseases can arise as well: approximately 35% of patients treated with alemtuzumab develop autoimmune thyroid disease within two years, and 2% of patients who take daclizumab have severe autoimmune dermatological side effects. Teriflunomide, fingolimod, natalizumab, mitoxantrone, interferon β1-a/b, and daclizumab can all damage the liver. There are also psychiatric, reproductive, and vaccineassociated risks and side effects that must be considered. CONCLUSION Newer drugs for MS have enabled more effective treatment, but are also associated with a higher risk of side effects. Interdisciplinary risk management is needed.
Melatonin applied to cucumber (Cucumis sativus L.) seeds improves germination during chilling stress

Abstract: The relationship between germination and melatonin applied during osmo‐ and hydropriming was studied in cucumber seeds. The proportion of nuclei with different DNA contents, the mean ploidy and the (2C + 4C = 8C)/2C ratio in unprimed and primed, dry and imbibed at 10°C seeds were established by flow cytometry. Thiobarbituric acid reactive substances and protein oxidation were also estimated. Melatonin and indole‐3‐acetic acid (IAA) concentrations in the seeds were determined using high‐performance liquid chromatography with electrochemical detection. Being sensitive to chilling stress, seeds that germinated well (99%) at 25°C showed only 30% germination at 15°C, and almost no germination (4%) at 10°C. Hydropriming in water improved seed germination to 50–60% at 15°C and the addition of melatonin (25–100 m) also increased the rate of germination. Osmopriming in polyethylene glycol increased germination at 15°C to 78%, and 98% when combined with 50 m melatonin. Osmoprimed seeds germinated even at 10°C and reached 43%, and 83% when 50 m melatonin was applied. None of the treatments induced DNA synthesis, although during the first 24 hr of imbibition at 10°C the mean ploidy and the (2C + 4C = 8C)/2C ratio increased, which is indicative of the advanced Phase II of germination. Hydro‐ and osmopriming slightly decreased IAA content in the seeds in most of the cases; only hydropriming with 100 and 500 m melatonin increased it. Melatonin protected membrane structure against peroxidation during chilling, but excessive melatonin levels in cucumber seeds (∼4 μg/g fresh weight) provoked oxidative changes in proteins. There is still lack of information explained clearly the role of melatonin in plant physiology. This molecule acts multidirectionally and usually is alliged to other compounds.
Obesity and Health-Related Decisions: An Empirical Model of The Determinants of Weight Status

Using Add Health, a very comprehensive longitudinal data set of teenagers and young adults in the United States, we estimate a structural dynamic model of the determinants of obesity. In addition to including many of the well-recognized endogenous factors mentioned in the literature as obesity determinants, i.e., physical activity, smoking, a proxy for food consumption, and childbearing, we also model the residential location as a choice variable, relevant to the young-to middle-aged adult, as a major component. This allows us to control for an individual’s self-selection into communities which possess the types of amenities in the built environment which in turn affect their behaviors such as physical activity and fast food consumption. We specify reduced form equations for all these endogenous demand decisions, together with an obesity structural equation. The whole system of equations is jointly estimated by a semi-parametric full information log-likelihood method that allows for a general pattern of correlation in the errors across equations. Simulations are then used to allow us to quantify the effects of these endogenous factors on the probability of obesity. A key finding is that controlling for residential self-selection has important substantive implications. To our knowledge, this has not been yet documented within a full information maximum likelihood framework.
Integration of Hybrid PV/Wind Generation System Using Fuzzy MPPT in Grid Connected System for Remote Area

Photovoltaic and wind are renewable energy resources that widely used and grow rapidly in fulfilling electricity demand. Powers from both technologies depend on sunlight intensity and wind speed. For small scale power generation, DC voltage from both technologies is low and requires step-up converter to raise DC voltage ratio before converted into AC voltage. To optimize this system, step-up converter must have high ratio and efficiency to a distance of wide voltage input. This paper proposed an operation simulation and arrangement of DC-DC converter along with DC-AC from hybrid source PV-Wind which integrated to grid utilities without using storage device. High Gain Integrated Cascade Boost (HGICB) is DC-DC converter that has quadratic voltage ratio and used in this research. Then DC link connected to Voltage Source Inverter (VSI) which interconnected with utility grid and controlled by current control method. The total installed capacity of hybrid source is 4.4 kW. Wind turbine uses PMSG along with full bridge rectifier. To maximize and stabilize the generated power, MPPT fuzzy is used. Result from the simulation shows that converter capable to maintain maximum power whether from PV and wind turbine which canalized to utility grid in various irradiation condition, wind speed, and grid load alteration.
Thermal and Rheological Properties of Crude Tall Oil for Use in Biodiesel Production

The primary objective of this work was to investigate the thermal and rheological properties of crude tall oil (CTO), a low-cost by-product from the Kraft pulping process, as a potential feedstock for biodiesel production. Adequate knowledge of CTO properties is a prerequisite for the optimal design of a cost-effective biodiesel process and related processing equipment. The study revealed the correlation between the physicochemical properties, thermal, and rheological behavior of CTO. It was established that the trans/esterification temperature for CTO was greater than the temperature at which viscosity of CTO entered a steady-state. This information is useful in the selection of appropriate agitation conditions for optimal biodiesel production from CTO. The point of interception of storage modulus (G′) and loss modulus (G′′) determined the glass transition temperature (40 °C) of CTO that strongly correlated with its melting point (35.3 °C). The flow pattern of CTO was modeled as a non-Newtonian fluid. Furthermore, due to the high content of fatty acids (FA) in CTO, it is recommended to first reduce the FA level by acid catalyzed methanolysis prior to alkali treatment, or alternatively apply a one-step heterogeneous or enzymatic trans/esterification of CTO for high-yield biodiesel production.
Learning Latent Features with Pairwise Penalties in Matrix Completion

Low-rank matrix completion (MC) has achieved great success in many real-world data applications. A latent feature model formulation is usually employed and, to improve prediction performance, the similarities between latent variables can be exploited by pairwise learning, e.g., the graph regularized matrix factorization (GRMF) method. However, existing GRMF approaches often use a squared L2 norm to measure the pairwise difference, which may be overly influenced by dissimilar pairs and lead to inferior prediction. To fully empower pairwise learning for matrix completion, we propose a general optimization framework that allows a rich class of (non-)convex pairwise penalty functions. A new and efficient algorithm is further developed to uniformly solve the optimization problem, with a theoretical convergence guarantee. In an important situation where the latent variables form a small number of subgroups, its statistical guarantee is also fully characterized. In particular, we theoretically characterize the complexity-regularized maximum likelihood estimator, as a special case of our framework. It has a better error bound when compared to the standard trace-norm regularized matrix completion. We conduct extensive experiments on both synthetic and real datasets to demonstrate the superior performance of this general framework.
Microfilaria in a Fine Needle Aspirate of Primary Solid Malignant Tumor of the Maxillary Antrum

BACKGROUND Lymphatic filarial disease is very common in tropical countries like India. The incidental finding of microfilariae in various benign cytologic smears is very common. Microfilariae in malignant effusions have also been reported, but their coexistence with solid malignant tumor at the primary site has not been reported so far. CASE A 45-year-old male presented with a painful, rapidly growing swelling over the right maxilla that had been present for three months. On routine fine needle aspiration cytology, a microfilaria along with squamous carcinoma cells in a primary solid malignant tumor of the maxillary antrum was found. CONCLUSION This is the first case reported in English of the incidental finding of a microfilaria in a primary tumor of the maxillary antrum.
Al2O3/TiO2 inverse opals from electrosprayed self-assembled templates

The fabrication of high optical quality inverse opals is challenging, requiring large size, three-dimensional ordered layers of high dielectric constant ratio. In this article, alumina/TiO2–air inverse opals with a 98.2% reflectivity peak at 798 nm having an area of 2 cm2 and a thickness of 17 µm are achieved using a sacrificial self-assembled structure of large thickness, which was produced with minimum fabrication errors by means of an electrospray technique. Using alumina as the first supporting layer enables the deposition of TiO2 at a higher temperature, therefore providing better optical quality.
Looking for biomarkers of Hg exposure by transcriptome analysis in the aquatic plant Elodea nuttallii

Recently developed genomics tools have a promising potential to identify early biomarkers of exposure to toxicants. In the present work we used transcriptome analysis (RNA-seq) of Elodea nuttallii –an invasive rooted macrophyte that is able to accumulate large amounts of metals- to identify biomarkers of Hg exposure. RNA-seq allowed identification of genes affected by Hg exposure and also unraveled plant response to the toxic metal: a change in energy/reserve metabolism caused by the inhibition of photosynthesis, and an adaptation of homeostasis networks to control accumulation of Hg. Data were validated by RT-qPCR and selected genes were further tested as biomarkers. Samples exposed in the field and to natural contaminated sediments clustered well with samples exposed to low metal concentrations under laboratory conditions. Our data suggest that this plant and/or this approach could be useful to develop new tests for water and sediment quality assessment.
Developing a vaccine to prevent otitis media caused by nontypeable Haemophilus influenzae

ABSTRACT Nontypeable Haemophilus influenzae (NTHi) is a predominant organism of the upper respiratory nasopharyngeal microbiota. Its disease spectrum includes otitis media, sinusitis, non-bacteremic pneumonia and invasive infections. Protein-based vaccines to prevent NTHi infections are needed to alleviate these infections in children and vulnerable populations such as the elderly and those with chronic obstructive pulmonary disease (COPD). One NTHi protein is included in a pneumococcal conjugate vaccine and has been shown to provide efficacy. Our lab has been interested in understanding the immunogenicity of NTHi vaccine candidates P6, protein D and OMP26 for preventing acute otitis media in young children. We expect that continued investigation and progress in the development of an efficacious protein based vaccine against NTHi infections is achievable in the near future.
Endocrine and psychological aspects of sexual dysfunction in Klinefelter patients

Klinefelter syndrome is a frequent cause of hypogonadism, but despite hundreds of publications on different aspects of Klinefelter syndrome, only a few studies dealt with sexual dysfunction. In particular, testosterone is critical for various aspects of sexual response, but its role on sexuality in Klinefelter syndrome patients is debatable and no studies have evaluated the efficacy of testosterone treatment on sexual dysfunction in these subjects. Furthermore, the impact of psychological and relational aspects on sexual function of Klinefelter syndrome subjects is poorly defined. In this study, we aimed to determine the presence and type of sexual dysfunctions in Klinefelter syndrome subjects; to correlate them with testosterone levels and psychosexological and relational domains; and to evaluate the effects of testosterone therapy. We studied 62 non‐mosaic naïve Klinefelter syndrome patients and 60 age‐matched controls by means of medical history, psychosexological history, 15‐item International Index of Erectile Function questionnaire, endocrine assessment, and dynamic penile color Doppler ultrasound. Twenty‐five hypogonadal Klinefelter syndrome patients were studied after 6 months of testosterone replacement therapy. Klinefelter syndrome subjects have reduced 15‐item International Index of Erectile Function scores regarding sexual desire, intercourse satisfaction, and overall satisfaction with respect to controls, and these aspects were significantly associated with testosterone levels. Klinefelter syndrome subjects had also higher prevalence of erectile dysfunction, but no relation with testosterone levels was evident. A high prevalence of a range of psychological disturbances was present in Klinefelter syndrome subjects with erectile dysfunction with respect to those without erectile dysfunction. No statistical difference in the prevalence of premature and delayed ejaculation was observed between Klinefelter syndrome and control subjects. Testosterone replacement therapy improved sexual desire, intercourse satisfaction, and overall satisfaction scores, but had no effect on erectile function. Penile color Doppler ultrasound was normal in all subjects. This study shows that sexual dysfunction in Klinefelter syndrome is multifactorial and related only in part to hypogonadism and largely to psychological disturbances. Evaluation and therapy of sexual dysfunction should include a combined andrological and psychosexological approach.
Identifying Generalizable Image Segmentation Parameters for Urban Land Cover Mapping through Meta-Analysis and Regression Tree Modeling

The advent of very high resolution (VHR) satellite imagery and the development of Geographic Object-Based Image Analysis (GEOBIA) have led to many new opportunities for fine-scale land cover mapping, especially in urban areas. Image segmentation is an important step in the GEOBIA framework, so great time/effort is often spent to ensure that computer-generated image segments closely match real-world objects of interest. In the remote sensing community, segmentation is frequently performed using the multiresolution segmentation (MRS) algorithm, which is tuned through three user-defined parameters (the scale, shape/color, and compactness/smoothness parameters). The scale parameter (SP) is the most important parameter and governs the average size of generated image segments. Existing automatic methods to determine suitable SPs for segmentation are scene-specific and often computationally intensive, so an approach to estimating appropriate SPs that is generalizable (i.e., not scene-specific) could speed up the GEOBIA workflow considerably. In this study, we attempted to identify generalizable SPs for five common urban land cover types (buildings, vegetation, roads, bare soil, and water) through meta-analysis and nonlinear regression tree (RT) modeling. First, we performed a literature search of recent studies that employed GEOBIA for urban land cover mapping and extracted the MRS parameters used, the image properties (i.e., spatial and radiometric resolutions), and the land cover classes mapped. Using this data extracted from the literature, we constructed RT models for each land cover class to predict suitable SP values based on the: image spatial resolution, image radiometric resolution, shape/color parameter, and compactness/smoothness parameter. Based on a visual and quantitative analysis of results, we found that for all land cover classes except water, relatively accurate SPs could be identified using our RT modeling results. The main advantage of our approach over existing SP selection approaches is that our RT model results are not scene-specific, so they can be used to quickly identify suitable SPs in other VHR images.
Influence of pin geometry on material flow in friction stir welding process

Abstract The material flow in friction stir welded 2014 Al alloy has been investigated using a marker insert technique (MIT). Results of the flow visualisation show that the material flow is asymmetrical during the friction stir welding (FSW) process and there are also significant differences in the flow patterns observed on advancing and retreating sides. Combining the data from all the markers, a three-dimensional (3D) flow visualisation similar to the 3D image reconstruction technique was obtained. The 3D plot gives the tendency chart of material flow in FSW process and from the plot it can be seen that there is a vertical and circular motion around the longitudinal axis of the weld. The influence of the pin geometry on material flow in FSW was studied. When the column and taper pin are used, there is a 'hole' defect in the vertical mixing plot. When the taper with screw thread pin is used, the vertical material flow is more obvious and there is no distinct 'hole'. Viewing from the advancing side, the pin geometry will affect the position where minimal transport distance against the welding direction occurs.
Schizophrenia: the role of sleep and circadian rhythms in regulating dopamine and psychosis

Abstract Schizophrenia has long been associated with abnormalities in circadian rhythms and sleep. Up until now, there have been no thorough reviews of the potential mechanisms behind the myriad of circadian and sleep abnormalities observed in schizophrenia and psychosis. We present evidence of sleep playing an important role in psychosis predominantly mediated by dopaminergic pathways. A synthesis of both human and animal experimental work suggests that the interplay between sleep and dopamine is important in the generation and maintenance of psychosis. In particular, both animal and human data point to sleep disruption increasing dopamine release and sensitivity. Furthermore, elevated dopamine levels disrupt sleep and circadian rhythms. The synthesis of knowledge suggests that circadian rhythms, dopamine dysregulation, and psychosis are intricately linked. This suggests that treatment of circadian disturbance may be a useful target in improving the lives and symptoms of patients with schizophrenia.
Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments

Neurofilaments possess side arms that comprise the carboxy-terminal domains of neurofilament middle and heavy chains (NFM and NFH); that of NFH is heavily phosphorylated in axons. Here, we demonstrate that phosphorylation of NFH side arms is a mechanism for regulating transport of neurofilaments through axons. Mutants in which known NFH phosphorylation sites were mutated to preclude phosphorylation or mimic permanent phosphorylation display altered rates of transport in a bulk transport assay. Similarly, application of roscovitine, an inhibitor of the NFH side arm kinase Cdk5/p35, accelerates neurofilament transport. Analyses of neurofilament movement in transfected living neurons demonstrated that a mutant mimicking permanent phosphorylation spent a higher proportion of time pausing than one that could not be phosphorylated. Thus, phosphorylation of NFH slows neurofilament transport, and this is due to increased pausing in neurofilament movement.