Miracle-dz/UniFAR-FTUs huggingface dataset:
Breast sarcoma. A clinicopathologic review of 25 cases

Sarcoma of the breast represents less than 1% of primary mammary malignancies; this study reports 25 such cases. The largest group had malignant fibrous histiocytoma (44%), followed by liposarcoma (24%) and fibrosarcoma (16%). Also represented were clear cell sarcoma, neurogenic sarcoma, leiomyosarcoma, and alveolar soft part sarcoma (4% each). Of 19 patients treated by wide local excision or simple mastectomy with or without adjuvant radiotherapy, 11 had local recurrence develop, of which one patient died and nine of the remaining ten had metastases develop. Of the remaining eight patients in this group with no local recurrence, only two had metastases develop. Of the six patients treated by radical or Patey mastectomy, none had local recurrence develop, but two died of metastases. No patient had metastases develop more than 5 years after diagnosis. Regional lymph node involvement with tumor was observed in only one patient (with malignant fibrous histiocytoma) despite regional lymphadenopathy in seven. The overall mortality at 5 years is 64% but does not increase thereafter. The authors' findings suggest that failure to establish local control is associated with a poor prognosis and that wide local excision or simple mastectomy does not provide sufficient clearance to be used as first‐line treatment. Excision of the axillary lymphatics and adjuvant radiotherapy are unlikely to be beneficial.
Interpretation of theoretical scattering mechanisms extracted from polarimetric target decomposition algorithms for sea ice applications

Outputs from coherent and incoherent decomposition methods are compared over a sea ice environment selected so that surface scattering be the dominant mechanism all over the scene. Our field observations revealed two types of ice: one formed at the onset of the winter season and the other formed later at spring in leads. Pressure ridges and rubble fields were also present on the old ice surfaces. Both methods were able to draw a satisfying map of the two ice types and localize pressure ridges. However the application of a Wishart classifier gives an improved resolution over the Pauli RGB. Two main differences emerge from our results. The intensity fluctuations of the return are better revealed on the Pauli RGB with forward scattering showing as dark areas. A parallel consequence is that areas where a strong forward scattering occurred were wrongly classified as dominated by a volume scattering mechanism. The incoherent method successfully classified all surfaces as dominated by a surface scattering mechanism.
Intravenous immunoglobulin therapy for patients with idiopathic cardiomyopathy and endomyocardial biopsy-proven high PVB19 viral load

Background Parvovirus B19 (PVB19) persistence in the heart has been associated with progressive cardiac dysfunction and evolution to dilated cardiomyopathy. In the present study, we investigated whether immunomodulation with intravenous immunoglobulin (IVIg) in addition to conventional heart failure therapy is safe and achieves virus reduction. Such therapy might improve cardiac function in patients with chronic dilated cardiomyopathy (DCM) and a significant PVB19 viral load in the heart. Methods PVB19 viral load was studied in 25 post-mortem cardiac samples of patients with a normal heart. Then, 17 consecutive patients (mean age 53 ±3 years) with DCM and symptomatic heart failure for >1 year with a PVB19 viral load in endomyocardial biopsies of >250 copies/μg DNA were treated with a high dose of IVIg (2 g/kg). Results The post-mortem cardiac samples revealed a PVB19 presence in 80% with a mean load of 131 ±40 copies/μg DNA. In the treated patients, IVIg resulted in a significant decrease of PVB19 viral load from 1,420 ±216 to 619 ±200 copies/μg DNA (P=0.004) and significantly improved the ejection fraction from 33 ±3% 6 months before treatment and 34 ±3% at baseline to 41 ±3% 6 months (P=0.001) after IVIg therapy. The New York Heart Association classification significantly improved from 2.5 ±0.1 at baseline to 2.1 ±0.1 at follow-up (P=0.004). No therapy-related complications were noted. Conclusion The present pilot study demonstrates that IVIg significantly reduces viral load and improves cardiac function in patients with DCM related to increased PVB19 viral load in the heart.
Local anesthetic-induced conduction block and nerve fiber injury in streptozotocin-diabetic rats.

Patients with diabetes may have peripheral neuropathy, which may have clinical implications for the use of regional nerve block. The effects of local anesthetics on nerve conduction and nerve fiber injury were tested in control rats and at 4 weeks after the onset of diabetes in rats injected with streptozotocin (50 mg/kg intraperitoneally). Nerve conduction was assessed by recording evoked electrical activity in hindpaw muscles following ipsilateral electrical stimulation of the sciatic nerve near the hip. Block of motor nerve conduction was quantified by recording the amplitude of the evoked response at 1-min intervals for up to 15 min after the injection of 500 microliters 1% lidocaine HCl or procaine HCl into the midthigh next to the sciatic nerve. In control animals, procaine was much less effective than lidocaine in producing conduction block. The rate and magnitude of lidocaine-induced conduction block were not significantly different between control and diabetic groups. However, conduction block due to procaine was sufficiently enhanced in diabetic rats to become comparable to that of lidocaine-treated control nerves. Long-lasting injury was assessed in sciatic nerve harvested 2 days after the extraneural injection of saline or 2 or 4% lidocaine HCl. Using a light microscope with a superimposed grid, nerve edema was quantified as the proportion of intersection points falling on extracellular space. Lidocaine induced edema in both control and diabetic nerves, but 4% lidocaine induced significantly more edema in diabetic nerves than in controls. Nerve fiber injury, based on light microscopic scoring of axonal degeneration and demyelination, was not observed in saline-treated nerves. (ABSTRACT TRUNCATED AT 250 WORDS)
The role of global brand familiarity, trust and liking in predicting global brand purchase intent: a Hungarianâ American comparison

This paper studies 20 global brands and attempts to understand how four brand constructs (Country of Origin (COO), familiarity, liking and trust) might influence the purchase intent of consumers living under different economic conditions. Study respondents were a random selection of adult consumers living in an emerging market economy, Hungary, and in an advanced market economy, the USA. Stepwise multiple regressions found significant differences between global brand purchase intent between these two consumer groups. The major study findings are the importance of global brand trust and liking as predictors of global brand purchase intent in Hungarian consumers and the unimportance of knowing a brand's COO in both Hungarian and US consumers.
Funding Education for Sustainable Development in Nigeria: Challenges and the Way Forward

Funding education for sustainable development is viewed in terms of what sustainable options for funding education are to be adopted for sustainable educational development in Nigeria. In analyzing this paper, the researcher established a problem and attributed the cause of unsustainable funding for education to a change in the price of oil, as a base of revenue generation in the country from 1970-2011. Optional for funding was viewed in terms of education as private good and public good, regular contributions from communities, state, large company and regular financial support from international organizations. Challenges and way forwards were based on the analysis that government should recognize basic education (that is primary and secondary education) as public good, accepts the responsibility of providing education free for all citizen and for tertiary education as private good, the private sector is encouraged to invest in and operate the provision of education base on market demand and supply framework. Keywords: Funding, Education, Sustainable, Development, Challenges
An Approach to Asset Pricing Under Incomplete and Diverse Perceptions

We model a dynamic, competitive market, where in every period, risk-neutral traders trade a one-period bond against an infinitely lived asset, with limited short-selling of the long-term asset. Traders lack structural knowledge and use different “incomplete theories,” all of which give statistically correct beliefs about next period's market price of the long-term asset. The more theories there are in the market, the higher is the equilibrium price of the long-term asset. Investors with more complete theories do not necessarily earn higher returns than those with less complete ones, who can earn above the risk-free rate. We provide two necessary conditions for a trader to earn above the risk-free rate.
Job Satisfaction of New Baccalaureate Nurses

Objective: The purpose of this study was to examine job satisfaction of recent RN graduates working in various specialty areas in outpatient and inpatient settings. The authors also examine job satisfaction for new graduates relative to intent to remain in their current position. Background: Retaining new nurses is one strategy for addressing the nursing shortage. By understanding aspects of their jobs that new nurses find satisfying, administrators can develop better retention and recruitment strategies. Methods: Participants completed the McCloskey-Mueller Satisfaction Scale (MMSS) rating their satisfaction with, and importance, of each item. Discrepancy scores were created by subtracting importance scores from satisfaction scores. Results: Nurses who intend to stay in their current position were significantly more satisfied than were those that did not intend to stay on 7 of the 8 MMSS subscales. There were no differences in their importance ratings. Inconsistent differences were found in the other comparisons. Conclusion: Administrators should give greater consideration to the role that satisfaction of new nurses plays in shaping future job intentions.
Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses

Reverse genetics, an approach to rescue infectious virus entirely from a cloned cDNA, has revolutionized the field of positive-strand RNA viruses, whose genomes have the same polarity as cellular mRNA. The cDNA-based reverse genetics system is a seminal method that enables direct manipulation of the viral genomic RNA, thereby generating recombinant viruses for molecular and genetic studies of both viral RNA elements and gene products in viral replication and pathogenesis. It also provides a valuable platform that allows the development of genetically defined vaccines and viral vectors for the delivery of foreign genes. For many positive-strand RNA viruses such as Japanese encephalitis virus (JEV), however, the cloned cDNAs are unstable, posing a major obstacle to the construction and propagation of the functional cDNA. Here, the present report describes the strategic considerations in creating and amplifying a genetically stable full-length infectious JEV cDNA as a bacterial artificial chromosome (BAC) using the following general experimental procedures: viral RNA isolation, cDNA synthesis, cDNA subcloning and modification, assembly of a full-length cDNA, cDNA linearization, in vitro RNA synthesis, and virus recovery. This protocol provides a general methodology applicable to cloning full-length cDNA for a range of positive-strand RNA viruses, particularly those with a genome of >10 kb in length, into a BAC vector, from which infectious RNAs can be transcribed in vitro with a bacteriophage RNA polymerase.
Evolving Concepts of Cardiac Valve Dynamics: The Continuum of Development, Functional Structure, Pathobiology, and Tissue Engineering

Considerable progress has been made in recent years toward elucidating a conceptual framework that integrates the dynamic functional structure, mechanical properties, and pathobiological behavior of the cardiac valves. This communication reviews the evolving paradigm of a continuum of heart valve structure, function, and pathobiology and explores its implications. Specifically, we discuss (1) the interactions of valve biology and biomechanics (eg, correlations of function with structure at the cell, tissue, and organ levels and mechanical considerations, development, endothelial cell and interstitial cell biology, extracellular matrix biology, homeostasis, and adaptation to environmental change); (2) mechanisms of disease (eg, valve cell and matrix pathobiology in congenital anomalies, aortic valve calcification, and mitral valve prolapse); (3) considerations in replacement and repair (eg, cell/matrix biology of tissue valve substitutes and their degeneration and durability of repairs); and (4) the potential for tissue engineering approaches to therapeutic regeneration of the cardiac valves. Opportunities for research and clinical translation are highlighted.
Temporal causality and the dynamics of different categories of crime and their socioeconomic determinants: evidence from Australia

Hale and Sabbagh (1991) failed to find cointegration (i.e. a long-term equilibrium relationship) between crime and unemployment in the case of England and Wales. The present study (basedon multiple cointegrationtests preceded by various unit root or non-stationarity tests) is the first attempt at putting the analysis of crime in a temporal Granger-causal framework in the Australian case (1963 - 90) by binding the relationship between different categories of crime and their socioeconomic determinants within a multivariate cointegrated system. The results, based on the most recent methodology, broadly indicate that, although the relative importance of the determinants of crime varied by type of crime, of all the determinants it is 'dwelling commencements' (a proxy for 'wealth') that appears to impact more or less on all the categories of crime significantly, followed by 'urbanization'.
Scholarly marketing publication: the American advantage?

Purpose – The purpose of this paper is to explore how much one's academic development and environment influence the way one performs, evaluates, writes and tries to publish basic, scholarly marketing research.Design/methodology/approach – A sample of results from initial journal submissions is used to empirically examine the potential reasons for rejection and the size and strength of main effects and interactions comprising the author's country of origin and the reviewer's country of origin.Findings – The findings, taken together, suggest a small but statistically significant advantage to US authors in avoiding rejection. This advantage is attributable to a relative superiority in expressing ideas in the English language and a better ability to logically develop theory. There is little evidence that suggests the advantage is due to a substantially more quantitative approach than that of others.Originality/value – The paper examines results of the review process from an actual sample of submitted papers a.
Training in different types of organizations: differences and dynamics in the organization of learning at work

This article focuses on differences and dynamics with respect to the organization of learning at work. It starts with a reflection on actual research perspectives on the subject of training in organizations. Four perspectives, which are currently dominant in the educational and social sciences, will be discussed: the structure-oriented approach, the system-oriented approach, the actor-oriented approach and the network approach. The network approach is a particularly promising new development in training research. We will elaborate this approach here and illustrate its potential by applying it to the analysis of training systems in two different types of organizations: bureaucratic and professional organizations. Data from recent case studies demonstrate that these types of organizations show remarkable differences with respect to the basic processes of their training systems: the shaping of training policies, the development of training programmes and the execution of training activities. In practice, tra.
Boosting organizational learning through team-based talent management: what is the evidence from large Spanish firms?

Talent management (TM) can crucially help optimize organizational learning (OL) processes. The aim of this article is to study whether certain TM practices related to teamwork design and dynamics stimulate and develop learning (i.e. knowledge creation) processes within the organization and across the different ontological levels (individual, group and organizational–institutional). A model linking team-based TM and OL is tested in a sample of large Spanish companies. Our empirical results emphasize the distinction between individual–group and institutional levels of learning as the two pillars of OL. The results also highlight the role of team autonomy and creativity as crucial factors for successful OL through team-based TM, especially for interlinking individual and group learning levels.
Hyperglycemia during critical illness.

BACKGROUND We sought to review the literature describing the benefits of tight glycemic control in critically ill patients, comparing outcome differences in subgroup populations. METHODS We searched PubMed for relevant literature on the topic of hyperglycemia and its management in the intensive care unit. RESULTS Overwhelming evidence in both surgical and medical patients conclusively demonstrates that hyperglycemia is a marker of severity of illness and is also an independent determinant of bad outcome, largely from infectious complications. Randomized trial evidence, in conjunction with historically controlled trials, supports the use of intensive insulin therapy and euglycemic control in critically ill patients, with nondiabetics possibly benefiting even more than diabetic patients. Euglycemia is best achieved, and hypoglycemia attenuated, through use of a protocolized approach. Further elaboration as to what threshold range defines euglycemia in patient subpopulations is needed and what pitfalls must be avoided in this practice. Development of continuous blood glucose monitoring has started and will someday be incorporated into routine practice in the same way that continuous electrocardiographic monitoring and pulse oximetry are standards of care in the intensive care unit. CONCLUSIONS Hyperglycemia is a predictor of death and complications in critically ill patients. Early aggregated study results show that control of hyperglycemia improves outcomes. Well-designed studies involving thousands of patients have started to better elucidate the concomitant promoters of hyperglycemia and to better quantify the benefits from tight glycemic control.
Comparison of metabolic parameters and Framingham cardiovascular risk scores before and after in‐hospital treatment with antipsychotics

Background. The objective of this naturalistic study was to evaluate changes in the prevalence of metabolic syndrome (MetS) and Framingham cardiovascular risk scores in adult with schizophrenia after inhospital treatment with antipsychotics. Methods. For 58 patients (36 women and 22 men) the following data was acquired on admission and at discharge: body height and weight, waist circumference, cigarette smoking, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides (TGA), fasting plasma glucose (FPG), blood pressure, concomitant use of antidiabetic, antihypertensive and antihyperlipidemic medications. results. Mean TGA levels increased significantly (140.32 mg/dL vs. 180.17 mg/dL), other parameters did not change. MetS prevalence on admission and at discharge did not differ significantly, irrespective of definition used (IDF: 50.00% vs. 60.34%; ATPIII: 39.66% vs. 43.10%; ATPIII A: 46.55% vs. 51.72%). Two cardiovascular risk scores were reduced at discharge: stroke, 10-year (4.10% vs. 3.46%) and hypertension, 4-year (22.18% vs. 16.58%). Other Framingham risk scores did not change. Very high prevalence of abnormal body weight (up to 65%), abdominal obesity (63% in men and 89% in women), hypertension (>50%) and lipid abnormalities (31-64%) was found. Conclusions. We have found a very high rate of MetS in patients treated with antipsychotics. No metabolic parameters improved after hospital stay, while some worsened. This did not, however, result in increased risk of cardiovascular events. Abnormal body weight and lipid abnormalities were very common in our study population. Our results indicate that metabolic parameters should be monitored regularly, particularly in outpatient settings, and appropriate treatment should be introduced as soon as any significant changes are found.
Strategizing through the capability lens: sources and outcomes of integration

Purpose – This paper aims to explore the concept of capabilities and where they come from as well as their impact on integration and performance.Design/methodology/approach – The paper is presented in the form of a theoretical development and literature review.Findings – This paper proposes a theory of capability development and discusses the conditions under which a capability is effective. In particular, for a capability to be effective both local and global coherence are required. But a capability effectiveness and coherence has an inverted U shape. It increases with coherence up to a certain threshold then decreases. As a result, the development of capability is a powerful integration mechanism that crosses levels and functions.Research limitations/implications – This is a theoretical paper; the propositions offered have still to be empirically tested.Practical implications – Opening up the capability black box might help managers better grasp how to develop and shape organizational capabilities that .
Has Inflation Persistence Changed under EMU?

Abstract This paper analyzes the persistence of inflation in the euro area and, in particular, whether the persistence properties have changed since the start of European Monetary Union(EMU). For that purpose, we compare pre- and post-EMU inflation persistence, use rolling-window estimates of persistence, and apply tests specifically designed to detect break dates near the end of the sample period. In contrast to previous research, we find that inflation persistence has fallen significantly since the start of EMU. Persistence of consumer price inflation, which is central to the European Central Bank’s policy mandate, has fallen more than the persistence of deflator inflation. The drop in inflation persistence is consistent with the results from a simulated small New Keynesian model with a shift toward a more aggressive monetary policy stance.
Should the cytologic diagnosis of “atypical squamous cells of undetermined significance” be qualified?

The diagnosis of atypical squamous cells of undetermined significance (ASCUS) remains an enigma for the treating physician, because it encompasses both benign, reactive, as well as preneoplastic and possibly neoplastic conditions. To address this problem, The Bethesda System recommends qualifying the ASCUS diagnosis. This study analyzes the difference in the follow‐up results between the various groups of patients with an ASCUS diagnosis as outlined by the Criteria Committee: favor premalignant (ASCUS‐P), favor reactive (ASCUS‐R), and unqualified (ASCUS‐C). The outcome, based on follow‐up biopsies and/or cytologies, for both the conventional Papanicolaou smear (CS) and liquid‐based (LB) methodologies is compared.
The Impact of Mergers and Acquisitions on People at Work: Existing Research and Issues

Mergers and acquisitions are a high risk form of business activity involving the collective annual investment of billions of pounds and affecting the working lives of millions of employees. It has been suggested that in the long term between 50–80 per cent of all mergers are considered to be financially unsuccessful (Marks, 1988b), and in terms of financial return, represent ‘at best an each way bet’ (Lorenz, 1986).