Miracle-dz/UniFAR-FTUs huggingface dataset:
Intracerebral Hemorrhages Associated With Neurointerventional Procedures Using a Combination of Antithrombotic Agents Including Abciximab

Background— We report the occurrence of fatal intracerebral hemorrhage associated with using a combination of antithrombotic agents, including abciximab, in patients undergoing neurointerventional procedures. Summary of Report— Seven patients (average age 60, range 46 to 73 years) developed fatal intracerebral hemorrhages associated with neurointerventional procedures and the use of intravenous abciximab. The procedures included angioplasty and stent placement in the cervical internal carotid artery (n=4), angioplasty of the intracranial internal carotid artery (n=1), and angioplasty of the middle cerebral artery (n=2). Clinical deterioration was observed within 1 hour of the procedure in 5 patients and 7 and 8 hours after the procedure, respectively, in the remaining 2 patients. All patients had received heparin and clopidogrel; 6 had also received aspirin. Conclusions— Intracerebral hemorrhages can occur after neurointerventional procedures in patients with recent cerebral ischemic events, particularly when aggressive antithrombotic treatment is used.
CREATING NEW GENETIC VARIABILITY IN SUNFLOWER USING INDUCED MUTATIONS

The objective of the study was to provide new genetic variability in important agronomic traits that can be exploited for improvement of sunflower production. Seeds of eight sunflower inbred lines from gene collection of Institute of Field and Vegetables, Novi Sad were irradiated with gamma rays (γ) and fast neutrons (Nf) and treated in ethyle-methane-sulphonate (EMS) solution. The manifestation of mutations was mostly expressed in M2 and M3 generation. Seven mutants were developed; one early flowering, two short stature and one high, two with higher oil content and one branching. The stable progenies were evaluated in micro-plot tests in M6 generation for seed yield and other traits in comparison with respective original line. Further studies should be focused on testing new mutant lines in hybrid combinations, as well as the determination of inheritance of mutant traits.
Ictal scalp EEG in temporal lobe epilepsy with unitemporal versus bitemporal interictal epileptiform discharges

Article abstract—We investigated the ictal scalp EEG in 228 seizures of 36 patients with unitemporal (n = 25) or bitemporal independent (n = 11) interictal epileptiform discharges (IED). All patients had proven temporal lobe epilepsy since they became seizure-free or only had auras after temporal lobectomy with a minimum follow-up of 1 year. Ictal patterns at seizure onset or later in the course of the seizure were lateralized significantly more often in patients with unitemporal IED (90%, at seizure onset and 96%, later) compared with those with bitemporal independent IED (75%, at seizure onset and 78%, later). Furthermore, scalp ictal EEGs, when lateralized at seizure onset or later in the course of the seizure, were significantly more likely to predict the correct side for surgery in patients with unitemporal (98%, at seizure onset and 100%, later) than bitemporal (64%, at seizure onset and 77%, later) IED. Bilateral independent seizure onsets, asynchrony of ictal activity over the two temporal lobes, and switch of ictal activity from one to the other hemisphere are ictal patterns that are strongly correlated with bitemporal excitability.
Recombinant adenoviral microRNA-206 induces myogenesis in C2C12 cells

Summary Background The expression of microRNA-206 (miR-206) is high in skeletal muscle but low in most other tissues. The expression of miR-206 is increased in muscular dystrophy, suggesting its involvement in the pathogenesis of muscle diseases. To determine the role of miR-206 in muscle cell differentiation and explore a possible gene therapy vector, we constructed a miR-206 adenoviral expression vector (AdvmiR-206) and tested for transfection into C2C12 stem cells. Material/Methods A 355-bp PCR amplicon from C57B6 mouse skeletal muscle genomic DNA was inserted into the adenoviral shuttle vector pAdTrack-CMV, which was then co-transformed with the adenoviral backbone plasmid pAdEasy-1 into competent E. coli BJ5183 bacteria. The specificity and function of this recombinant adenoviral MiR-206 were studied in C2C12 cells by Northern blot, immunofluorescence, Western blot, and flow cytometry. Results Increased expression of miR-206 in AdvmiR-206 transfected C2C12 cells (P<0.001) and resulted in morphological and biochemical changes over time that were similar to serum deprivation, including elongated cells and increased myosin heavy chain proteins. Even in the absence of serum deprivation, miR-206 overexpression accounted for a 50% reduction of S-phase cells (P<0.01). Moreover, in untransfected C2C12 cells, the introduction of miR-206-specific antisense oligoribonucleotides inhibited the normal response to serum deprivation. Twenty-four hours after lipofection of antisense oligoribonucleotides, the number of elongated cells was reduced by half (P<0.01). Conclusions Collectively, these data support a role for miR-206 in myoblast differentiation. We foresee potential applications for the AdvmiR-206 vector in research and therapy.
Oligodendrocyte progenitor cells proliferate and survive in an immature state following treatment with an axolemma-enriched fraction

The ability of an AEF (axolemma-enriched fraction) to influence the proliferation, survival and differentiation of OPC (oligodendrocyte progenitor cells) was evaluated. Following addition of AEF to cultured OPC, the AEF associated with the outer surface of OPC so that subsequent metabolic events were likely mediated by direct AEF-OPC contact. Addition of AEF to the cultured OPC resulted in a dose- and time-dependent increase in proliferation that was partially dependent on Akt (protein kinase B) and MAPK (mitogen-activated protein kinase) activation. The major mitogen in an AEF-SE (soluble 2.0 M NaCl extract of the AEF) was identified as aFGF (acidic fibroblast growth factor) and accounted for 50% of the mitogenicity. The remaining 50% of the mitogenicity had properties consistent with bFGF (basic fibroblast growth factor) but was not unequivocally identified. Under conditions that limit the survival of OPC in culture, AEF treatment prolonged the survival of the OPC. Antigenic and morphological examination of the AEF-treated OPC indicated that the AEF treatment helped the OPC survive in a more immature state. The potential downstream metabolic pathways potentially activated in OPC by AEF and the consequences of these activated pathways are discussed. The results of these studies are consistent with the view that direct contact of axons with OPC stimulates their proliferation and survival while preventing their differentiation.
Lexical, morphological and syntactic development in toddlers between 16 and 30 months old: A comparison across European Portuguese and Galician

The main aims of this study were to investigate the relationship between the lexical size and the emergence of morphological and syntactic markers in toddlers between the ages of 16 and 30 months and to compare these results between Galician and European Portuguese. Parents of 3012 Portuguese toddlers and those of 1081 Galician toddlers completed the MacArthur–Bates Communicative Development Inventory: Words and Sentences. The results indicated that the number of words, the ability to combine words and the number of different morphemes produced increased with age. The ability to combine words was used as an indicator of syntactic development; this ability was also associated with the toddlers’ lexical size. In both samples, gender morphemes seemed to be the first to have their production generalized, followed by the plural and the past participle. The production of gender morphemes was accompanied by a small lexical size, whereas the imperfect tense and the person mark onset were associated with large lexical sizes. The implications of these results for charting the continuity between lexical, morphological and syntactical development are discussed.
Hexylaminolevulinate photodynamic diagnosis for multifocal recurrent nonmuscle invasive bladder cancer.

OBJECTIVE To determine the potential for hexylaminolevulinate (HAL) photodynamic diagnosis (PDD) to improve the management of multifocal recurrent nonmuscle-invasive bladder cancer (NMIBC). PATIENTS AND METHODS Patients with a history of NMIBC and with at least two suspected papillary recurrences were enrolled in this prospective study between April 2005 and October 2006. The photosensitizer was hexylaminolevulinate (HAL) (PhotoCure, Norway), and the Storz D-light system was used to detect fluorescence. The bladder was mapped initially under white light and then using HAL-photodynamic diagnosis (PDD). The number and types of additional lesions detected by HAL-PDD over white light cystoscopy were measured. RESULTS Eighteen patients (11 men), median age 74 years (range 35-84 yrs), underwent HAL-PDD. The median HAL instillation time was 109 minutes (range 60-250 min). Recurrent bladder cancer was confirmed histologically in 14/18 (78%) patients. Additional pathology was detected in 8/14 (57%) patients with confirmed recurrence and confirmed histologically in 6 of these. Additional pathology was papillary in 5/6 (83%) patients, and flat pathology was found in all six patients with additional foci. Carcinoma in situ (CIS) was detected in 4/6 (67%) patients with additional foci, three of whom were subsequently treated with intravesical bacille Calmette-Guérin (BCG). The sensitivity of HAL-PDD for the detection of tumor was 97.8%, compared with 69.6% for white light cystoscopy. The false-positive fluorescence-guided biopsy rate was 18/63 (29%). CONCLUSION HAL-PDD allows more complete management of bladder tumor in patients with multifocal recurrence. The high frequency of additional lesions detected and the rate of detection of CIS suggest that HAL-PDD should be the standard of care.
Effects of ISO 9001 on Non-Financial and Financial Performance in the Organizations: A Review

The main purpose of this paper was to specify the impact of ISO 9001 on financial and non-financial performance. For this aim, a comprehensive literature review was carried out on the scholarly published studies, which investigated empirically the effects of ISO 9001 standard on the organization's performance in different sectors. Subsequently, the ISO 9001 studies identified and selected carefully that were relevant to the objectives and criteria of the study with the aim of achieving the results and making conclusions. The analysis of the results of the empirical studies uncovered that ISO 9001 significantly affected production process (internal business process), while this standard was not correlated with the indicators of innovation and learning perspective at significant level. Furthermore, the systematic review of the existing literature provided enough evidence that the effectiveness of ISO 9001 on customer's results and financial performance were unclear and contradictory.
Effects of intradialytic exercise on the physical function, depression and quality of life for haemodialysis patients: a systematic review and meta‐analysis of randomised controlled trials

AIMS AND OBJECTIVES To determine the efficacy and safety of intradialytic exercises for haemodialysis patients, this study conducted a systematic review and meta-analysis of randomised controlled trials. BACKGROUND Patients receiving haemodialysis have poor physical function, psychological status and quality of life than the general population. Exercise training may improve these parameters for haemodialysis patients. DESIGN Systemic review was performed, and a meta-analysis was conducted. METHODS Medline, PubMed, Cochrane Central Register of Controlled Trials, SPORTDiscus, Cumulative Index to Nursing and Allied Health Literature and Airiti Library were systematically searched for studies up to January 2015. In addition, the reference lists of eligible studies and relevant reviews were assessed. RESULTS Seventeen studies with a total of 651 participants were included. Compared with no resistance exercise, nonexercise and walks at home, intradialytic exercises significantly improved the peak oxygen consumption (SMD = 0·50, 95% CI: 0·26-0·74), haemoglobin (SMD = 0·34, 95% CI: 0·13-0·55), depression (SMD = -0·80, 95% CI: -1·10 to -0·50) and physical component of the quality of life (SMD = 0·46, 95% CI: 0·20-0·73). Intradialytic exercises are safe with no adverse events. However, significant improvements were not observed in the albumin level and mental component of the quality of life. CONCLUSIONS The study results facilitate selecting intradialytic exercise that improves and provides safety with respect to the peak oxygen consumption, haemoglobin, depression and physical component of the quality of life. Furthermore, regular exercise should be considered a crucial therapeutic modality for patients undergoing haemodialysis. RELEVANCE TO CLINICAL PRACTICE This study suggests that performing intradialytic exercises for 30 minutes per session three times a week for at least ≥8 weeks is beneficial. Regular exercise should be considered as a crucial therapeutic modality of managing patients undergoing haemodialysis, thus guiding in clinical practice.
Government performance, social capital and ethnicity: understanding provincial development in Papua New Guinea

68 Pacific Economic Bulletin Volume 17 Number 2 October 2002 © Asia Pacific Press This article identifies ways to develop more effective government institutions in Papua New Guinea. The economy of Papua New Guinea has been well researched over recent years, but the relationship between its economic development strategies and its political and institutional processes is less well understood. Western policy advisers have often speculated about the ways in which socio-political and cultural factors can impact on government in Papua New Guinea. A key question is whether it is realistic to model government institutions in developing countries along the same lines as similar institutions in Western countries. It is often argued that the prospects for effective government depend on the level of economic and financial resources (see, for example, Israel 1987). It is clear that cultural, social and economic factors all affect the performance of government institutions, but Serra argues that the issue is not the amount of resources, but ‘the existence of certain conditions for resources to be channeled effectively into priority goals’ (Serra 1998:3). Government performance, social capital and ethnicity: understanding provincial development in Papua New Guinea
Bumble bee pollen use and preference across spatial scales in human-altered landscapes

1. While the discussion of native pollinator decline has grown dramatically worldwide, information on how native pollinators utilise floral resources in natural and human-altered landscapes remains relatively limited. Specifically, little is known about the collection of pollen, an essential component of larval and adult bee food, and whether pollen collection patterns change across habitats, spatial scales, and/or native and non-native floral resource distributions. 2. In this study, the pollen collection patterns and preferences of the yellow-faced bumble bee, Bombus vosnesenskii , were examined across a gradient of natural and human-altered sites. 3. Three hypotheses were investigated: (i) landscape-scale (2 km) but not local-scale (250 m) floral and habitat composition factors are most predictive of bee-collected pollen composition; (ii) collection of native pollen is greater in sites with greater proportions of natural habitat at landscape scales; and (iii) bees exhibit greater ‘preference’ for native versus non-native pollen. 4. Bombus vosnesenskii collected more species of pollen when landscape-scale riparian forest cover was low but localand landscape-scale floral species richness was high. Also, B. vosnesenskii collected pollen from a wide range of plant families and did not exhibit a significant preference for native versus non-native species. 5. Finally, preference analysis indicated that the only significant preference exhibited by B. vosnesenskii during the study period was for Heteromeles arbutifolia , a native shrub. Overall, results from this study reveal the importance of species-rich floral patches (native and non-native) for pollinator provisioning across natural and humanaltered landscapes.
Stroke-based creation of depth maps

Depth information opens up a lot of possibilities for meaningful editing of photographs. So far, it has only been possible to acquire depth information by either using additional hardware, restrictive scene assumptions or extensive manual input. We developed a novel user-assisted technique for creating adequate depth maps with an intuitive stroke-based user interface. Starting from absolute depth constraints as well as surface normal constraints, we optimize for a feasible depth map over the image. We introduce a suitable smoothness constraint that respects image edges and accounts for slanted surfaces. We illustrate the usefulness of our technique by several applications such as depth of field reduction and advanced compositing.
CMOS implementation of a low power absolute value comparator circuit

Absolute value comparators are becoming essential building blocks for new biomedical signal processing systems. Direct conversion of conventional comparators, which work on actual signal values, into absolute value comparators involve full wave rectifiers and this is suboptimal for a number of reasons. This paper presents a novel absolute value comparator circuit implemented without the use of full-wave rectifier blocks and with low complexity. The overall circuit consumes 113 nW from a 1V supply and is suitable for processing bio-signals in low power biomedical systems. The circuit has been fabricated in a 0.35 μm CMOS technology occupying an area of 0.07 mm2. A top-level implementation and analysis has also been presented. This would allow designers to perform comparisons between absolute values of input signals, by changing the circuit level implementations of each of the blocks to meet the system target specifications.
Alterations of gene profiles in Leydig-cell-regenerating adult rat testis after ethane dimethane sulfonate-treatment

Only occupying about 1%-5% of total testicular cells, the adult Leydig cell (ALC) is a unique endocrine cell that produces androgens. Rat Leydig cells regenerate after these cells in the testis are eliminated with ethane dimethane sulfonate (EDS). In this study, we have characterized Leydig cell regeneration and messenger ribonucleic acids (mRNA) profiles of EDS treated rat testes. Serum testosterone, testicular gene profiling and some steroidogenesis-related proteins were analyzed at 7, 21, 35 and 90 days after EDS treatment. Testicular testosterone levels declined to undetectable levels until 7 days after treatment and then started to recover. Seven days after treatment, 81 mRNAs were down-regulated greater than or equal to two-fold, with 48 becoming undetectable. These genes increased their expression 21 days and completely returned to normal levels 90 days after treatment. The undetectable genes include steroidogenic pathway proteins: steroidogenic acute regulatory protein, Scarb1, Cyp11a1, Cyp17a1, Hsd3b1, Cyp1b1 and Cyp2a1. Seven days after treatment, there were 89 mRNAs up-regulated two-fold or more including Pkib. These up-regulated mRNAs returned to normal 90 days after treatment. Cyp2a1 did not start to recover until 35 days after treatment, indicating that this gene is only expressed in ALCs not in the precursor cells. Quantitative polymerase chain reaction, western blotting and semi-quantitative immunohistochemical staining using tissue array confirmed the changes of several randomly picked genes and their proteins.
A Methodology for Locating Translations of Specialized Collocations

This paper presents a method for locating translations of specialized collocations for the purpose of balancing lists of collocations in specialized resources. The main steps of the method are: 1. Identifying collocations in a source language for which translations are missing in a target language using an encoding based on lexical functions (Mek’čuk 1996); 2. Locating possible translations of the collocates in the source language in a bilingual resource; 3. Validating equivalents of the target language equivalents in a specialized corpus. In this paper, we focus more specifically on English and French collocations in the domain of the environment. We tested the method manually using 26 English terms and the collocations in which these terms appear and sought to locate translations of these collocations in French. Results show that this strategy for finding translations of collocations is promising and can help terminologists locate and validate collocates in a given language more quickly. With some adaptations, the method could be automated, but human validation is required, especially during step 3.
Real Exchange Rate Misalignment: A Panel Co-Integration and Common Factor Analysis

We combine some newly developed panel co-integration techniques and common factor analysis to analyze the behavior of the real exchange rate (RER) in a sample of 64 developing countries. We study the dynamic of the RER with its economic fundamentals: productivity, the terms of trade, openness, and government spending. We derive a number of common factors that explain the dynamic of the RER in our sample. We find that while some fundamentals such as productivity, terms of trade, and openness are strongly related to these common factors in low-income countries, no such link is found for the middle-income countries. We also derive the misalignment indices, which seem to reproduce recent episodes of overvaluation and undervaluation in a number of countries.
Anisotropy of domain growth in epitaxial ferroelectric capacitors

Piezoresponse force microscopy (PFM) has been applied to investigate the switching kinetics in microscale epitaxial Pb(Zr,Ti)O3 capacitors. It is shown that transition from low to high field range brings about a qualitative change in domain growth kinetics, namely, laterally isotropic growth in the high fields as opposed to highly anisotropic growth in the low fields. It is suggested that anisotropy of domain growth can be attributed to orientational variations in the activation energy due to film microstructure. Fitting the switching kinetics using the Kolmogorov–Avrami–Ishibashi model shows excellent agreement with the PFM experimental data and yields the integer values of domain dimensionality.
Imaging of the Posttherapeutic Brain

Abstract This review covers important topics relating to the imaging evaluation of glioblastoma multiforme after therapy. An overview of the Macdonald and Response Assessment in Neuro-Oncology criteria as well as important questions and limitations regarding their use are provided. Pseudoprogression and pseudoresponse as well as the use of advanced magnetic resonance imaging techniques such as perfusion, diffusion, and spectroscopy in the evaluation of the posttherapeutic brain are also reviewed.
Ablation for Atrial Fibrillation Left ventricular systolic dysfunction by itself does not influence outcome of atrial fibrillation ablation

CLINICAL RESEARCH Ablation for Atrial Fibrillation