Miracle-dz/UniFAR-FTUs huggingface dataset:
Spectrophotometric Method for Estimation of Sitagliptin Phosphate in Bulk and Tablet Dosage Form

Two simple, precise and economical UV methods have been developed for estimation of Sitagliptin Phosphate in bulk formulation. Sitagliptin Phosphate has the absorbance maxima in zero order spectra is 267nm. First order derivative for the analysis of Sitagliptin Phosphate at 275nm. Drug followed Beer-Lambert’s law in the concentration range of 20-70μg/ml for both the methods. Results of analysis were validated statistically and were found to be satisfactory. Thus proposed methods can be successfully applied for estimation of Sitagliptin phosphate in routine analytical work.
An HST/COS legacy survey of high-velocity ultraviolet absorption in the Milky Way's circumgalactic medium and the Local Group

To characterize the absorption properties of this circumgalactic medium (CGM) and its relation to the LG we present the so-far largest survey of metal absorption in Galactic high-velocity clouds (HVCs) using archival ultraviolet (UV) spectra of extragalactic background sources. The UV data are obtained with the Cosmic Origins Spectrograph (COS) onboard the Hubble Space Telescope (HST) and are supplemented by 21 cm radio observations of neutral hydrogen. Along 270 sightlines we measure metal absorption in the lines of SiII, SiIII, CII, and CIV and associated HI 21 cm emission in HVCs in the velocity range |v_LSR|=100-500 km s^-1. With this unprecedented large HVC sample we were able to improve the statistics on HVC covering fractions, ionization conditions, small-scale structure, CGM mass, and inflow rate. For the first time, we determine robustly the angular two point correlation function of the high-velocity absorbers, systematically analyze antipodal sightlines on the celestial sphere, and compare the absorption characteristics with that of Damped Lyman alpha absorbers (DLAs) and constrained cosmological simulations of the LG. Our study demonstrates that the Milky Way CGM contains sufficient gaseous material to maintain the Galactic star-formation rate at its current level. We show that the CGM is composed of discrete gaseous structures that exhibit a large-scale kinematics together with small-scale variations in physical conditions. The Magellanic Stream clearly dominates both the cross section and mass flow of high-velocity gas in the Milky Way's CGM. The possible presence of high-velocity LG gas underlines the important role of the local cosmological environment in the large-scale gas-circulation processes in and around the Milky Way (abridged).
Comparison of two DNA extraction methods for dry Leaf Dipterocarpaceae

DNA extraction is the first step in obtaining high-concentration and high-purity DNA that can use in the subsequent steps. Because the leaf structure is challenging and contains several secondary metabolites that can affect DNA extraction results, DNA extraction on dry leaves of Dipterocarpaceae is considered problematic. This research aims to find a suitable method for extracting DNA from the preserved Dipterocarpaceae leaves. Preserved leaves of Dipterocarpaceae in silica gel will dry up, making them tough to destroy. Perform DNA extraction is generally using CTAB buffers or extraction kits. According to the results of this study, extraction with modified CTAB buffer result in DNA with higher concentration and purity values than DNA extracted with the kit. DNA isolated from the modified CTAB can be used as a template in the PCR process to amplify the matK gene.
Ni-based transition metal trichalcogenide monolayer: A strongly correlated quadruple-layer graphene

We investigate the electronic physics of layered Ni-based trichalcogenide NiPX$_3$ (X=S, Se), a member of transition-metal trichalcogenides (TMTs) with the chemical formula, ABX$_3$. These Ni-based TMTs distinguish themselves from other TMTs as their low energy electronic physics can be effectively described by the two $e_g$ d-orbitals. The major band kinematics is characterized by the unusal long-range effective hopping between two third nearest-neighbor (TNN) Ni sites in the two-dimensional Ni honeycomb lattice so that the Ni lattice can be equivalently viewed as four weakly coupled honeycomb sublattices. Within each sublattice, the electronic physics is described by a strongly correlated two-orbital graphene-type model that results in an antiferromagnetic (AFM) ground state near half filling. We show that the low energy physics in a paramagnetic state is determined by the eight Dirac cones which locate at $K$, $K'$, $\frac{K}{2}$ and $\frac{K'}{2}$ points in the first Brillouin zone with a strong AFM fluctuation between two $K (K')$ and $\frac{K'}{2} (\frac{K}{2})$ Dirac cones and carrier doping can sufficiently suppress the long-range AFM order and allow other competing orders, such as superconductivity, to emerge. The material can be an ideal system to study many exotic phenomena emerged from strong electron-electron correlation, including a potential $d\pm id$ superconducting state at high temperature.
Test of the FLRW Metric and Curvature with Strong Lens Time Delays

We present a new model-independent strategy for testing the Friedmann–Lemaître–Robertson–Walker (FLRW) metric and constraining cosmic curvature, based on future time-delay measurements of strongly lensed quasar-elliptical galaxy systems from the Large Synoptic Survey Telescope and supernova observations from the Dark Energy Survey. The test only relies on geometric optics. It is independent of the energy contents of the universe and the validity of the Einstein equation on cosmological scales. The study comprises two levels: testing the FLRW metric through the distance sum rule (DSR) and determining/constraining cosmic curvature. We propose an effective and efficient (redshift) evolution model for performing the former test, which allows us to concretely specify the violation criterion for the FLRW DSR. If the FLRW metric is consistent with the observations, then on the second level the cosmic curvature parameter will be constrained to ∼0.057 or ∼0.041 (1σ), depending on the availability of high-redshift supernovae, which is much more stringent than current model-independent techniques. We also show that the bias in the time-delay method might be well controlled, leading to robust results. The proposed method is a new independent tool for both testing the fundamental assumptions of homogeneity and isotropy in cosmology and for determining cosmic curvature. It is complementary to cosmic microwave background plus baryon acoustic oscillation analyses, which normally assume a cosmological model with dark energy domination in the late-time universe.
ALMA Mapping of Rapid Gas and Dust Variations in Comet C/2012 S1 (ISON):New Insights into the Origin of Cometary HNC

Observations of the sungrazing comet C/2012 S1 (ISON) were carried out using the Atacama Large Millimeter/submillimeter Array at a heliocentric distance of 0.58–0.54 au (pre-perihelion) on 2013 November 16–17. Temporally resolved measurements of the coma distributions of HNC, CH3OH, H2CO, and dust were obtained over the course of about an hour on each day. During the period UT 10:10–11:00 on November 16, the comet displayed a remarkable drop in activity, manifested as a >42% decline in the molecular line and continuum fluxes. The H2CO observations are consistent with an abrupt, ≈50% reduction in the cometary gas production rate soon after the start of our observations. On November 17, the total observed fluxes remained relatively constant during a similar period, but strong variations in the morphology of the HNC distribution were detected as a function of time, indicative of a clumpy, intermittent outflow for this species. Our observations suggest that at least part of the detected HNC originated from degradation of nitrogen-rich organic refractory material, released intermittently from confined regions of the nucleus. By contrast, the distributions of CH3OH and H2CO during the November 17 observations were relatively uniform, consistent with isotropic outflow and stable activity levels for these species. These results highlight a large degree of variability in the production of gas and dust from comet ISON during its pre-perihelion outburst, consistent with repeated disruption of the nucleus interspersed with periods of relative quiescence.
Realizing Q > 300 000 in diamond microdisks for optomechanics via etch optimization

Nanophotonic structures in single--crystal diamond (SCD) that simultaneously confine and co-localize photons and phonons are highly desirable for applications in quantum information science and optomechanics. Here we describe an optimized process for etching SCD microdisk structures designed for optomechanics applications. This process allows the optical quality factor, $Q$, of these devices to be enhanced by a factor of 4 over previous demonstrations to $Q \sim 335,000$, which is sufficient to enable sideband resolved coherent cavity optomechanical experiments. Through analysis of optical loss and backscattering rates we find that $Q$ remains limited by surface imperfections. We also describe a technique for altering microdisk pedestal geometry which could enable reductions in mechanical dissipation.
Investigating the Relation between Galaxy Properties and the Gaussianity of the Velocity Distribution of Groups and Clusters

We investigate the dependence of stellar population properties of galaxies on group dynamical stage for a subsample of the Yang catalog. We classify groups according to their galaxy velocity distribution into Gaussian (G) and Non-Gaussian (NG). Using two totally independent approaches, we have shown that our measurement of Gaussianity is robust and reliable. Our sample covers Yang’s groups in the redshift range 0.03 z 0.1, with mass . The new method, called Hellinger Distance, to determine whether a group has a velocity distribution Gaussian or NG is very effective in distinguishing between the two families. NG groups present halo masses higher than the G ones, confirming previous findings. Examining the skewness and kurtosis of the velocity distribution of G and NG groups, we find that faint galaxies in NG groups are mainly infalling, for the first time, into the groups. We show that considering only faint galaxies in the outskirts; those in NG groups are older and more metal-rich than those in G groups. Also, examining the Projected Phase Space of cluster galaxies, we see that bright and faint galactic systems in G groups are in dynamical equilibrium—which does not seem to be the case in NG groups. These findings suggest that NG systems have a higher infall rate, assembling more galaxies that have experienced preprocessing before entering the group.
A Model Approach to Understanding Monetary Aggregates Growth in Sierra Leone and Implications for Policy Formulation

This study has adopted a model approach to developing an understanding of monetary aggregates (MA) growth in Sierra Leone, which certainly has implications for effective policy formulation by the central bank authority. In pursuance of this, we utilized the Autoregressive Moving Average (ARIMA) model with data spanning 2002M1 to 2021M12 to investigate the out-of-sample projection performance of the disaggregated components that makes up the MA for Sierra Leone – typically in this case Reserve Money (RMA), Currency-in-Circulation (CiC) and Reserve Money (RM). In our evidence from the empirical projection (covering the period 2022M1-2022M12), we observed that RM is projected to grow more than CiC over the observed period. Given RM being the operational target of the Bank of Sierra Leone, we believe that such an outcome is a promising indication particularly in ensuring the bank addresses its core mandates of monitoring price and financial stability. The increased scope of RM in the BSL system is a laudable outcome when it comes to meeting reserve requirements and also managing risks about price and financial stability. The study recommends that the BSL adopt innovation strategies concerned with FinTech and the emergence of the National Switch to effectively manage the MA portfolio in the entire banking system, which will also support the overall growth ambition of the central government.
Constraining pre-big-bang nucleosynthesis expansion using cosmic antiprotons

A host of dark energy models and nonstandard cosmologies predict an enhanced Hubble rate in the early Universe: perfectly viable models, which satisfy big bang nucleosynthesis (BBN), cosmic microwave background and general relativity tests, may nevertheless lead to enhancements of the Hubble rate up to many orders of magnitude. In this paper we show that strong bounds on the pre-BBN evolution of the Universe may be derived, under the assumption that dark matter is a thermal relic, by combining the dark matter relic density bound with constraints coming from the production of cosmic-ray antiprotons by dark matter annihilation in the Galaxy. The limits we derive apply to the Hubble rate around the temperature of dark matter decoupling. For dark matter masses lighter than 100 GeV, the bound on the Hubble rate enhancement ranges from a factor of a few to a factor of 30, depending on the actual cosmological model, while for a mass of 500 GeV the bound falls in the range 50-500. Uncertainties in the derivation of the bounds and situations where the bounds become looser are discussed. We finally discuss how these limits apply to some specific realizations of nonstandard cosmologies: a scalar-tensor gravity model, kination modelsmore » and a Randall-Sundrum D-brane model. « less
Dynamical T‐matrix theory for high‐density excitons in coupled quantum wells

Excitons in coupled quantum wells open the possibility to reach high densities close to equilibrium. In a recent experiment employing a lateral trap potential, a blue shift and a broadening of the exciton emission line has been seen [D. W. Snoke et al., Solid State Commun. 134, 37 (2005)]. The standard Hartree–Fock treatment can explain the blue shift but fails to give a finite broadening. Starting from the (spin‐dependent) many‐exciton Hamiltonian with direct and exchange potential, we present a dynamical T‐matrix calculation for the single‐exciton Green's function which is directly related to the frequency‐ and angle‐resolved photoluminescence. The calculated spectrum is blue shifted and broadened due to exciton–exciton scattering. At high excitation, both the spectrum and the angular emission are getting narrow. This is a direct manifestation for off‐diagonal long range order and a precursor of condensation. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Renormalization of discrete-time quantum walks with a non-Grover coin

We present an in-depth analytic study of discrete-time quantum walks driven by a non-reflective coin. Specifically, we compare the properties of the widely-used Grover coin CG that is unitary and reflective (CG2=I) with those of a 3×3 ‘rotational’ coin C60 that is unitary but non-reflective (C602≠I) and satisfies instead C606=I, which corresponds to a rotation by 60∘. While such a modification apparently changes the real-space renormalization group (RG) treatment, we show that nonetheless this non-reflective quantum walk remains in the same universality class as the Grover walk. We first demonstrate the procedure with C60 for a three-state quantum walk on a one-dimensional (1d) line, where we can solve the RG-recursions in closed form in a process providing exact solutions for some difficult non-linear recursions. Then, we apply the procedure to a quantum walk on a dual Sierpinski gasket (DSG), for which we ultimately reproduce the same results found for CG, further demonstrating the robustness of the universality class.
First Steps Toward a Method for Estimating Cosmological Parameters using Strong Lensing, X-ray and Dynamics Total Mass Estimates

In this thesis we want to introduce the first steps towards realising a new method to investigate the cosmological parameters and conduct a detailed analysis of the galaxy cluster MACS J0416. Toward this end, we use the current model from Grillo et al. (2015) as a template and the publicly available lensing code Lenstool. This code has previously been used by Jauzac et al. (2014), Richard et al. (2014), Jauzac et al. (2015) and Caminha et al. (2016) to model MACS J0416 (Grillo et al. (2015) used GLEE). We created $10$ different models to cover a reasonable set of different approaches. In addition to the replication of the Grillo et al. (2015) models, with two cluster scale halos and 175 circular cluster member mass-density profiles, we created models using elliptical mass-density profiles for the cluster members and models where we optimize the cluster member scaling relation slopes. In order to investigate the viability of using the projected total mass estimate from different cosmological models to estimate the cosmological parameter values, we created 49 models each representing a different set of cosmological parameters.
Redefining North Atlantic right whale habitat‐use patterns under climate change

Changes in the physical oceanography of the Northwest Atlantic stemming from both natural and anthropogenic climate change impact the foraging ecology and distribution of endangered North Atlantic right whales. In this study, right whale sightings from 1990 to 2018 were analyzed to examine decadal patterns in monthly habitat use in 12 high‐use areas. Depth‐integrated abundances of late‐stage Calanus finmarchicus and Calanus hyperboreus were also analyzed for decadal variations in the right whale foraging habitats. There were significant differences in the occurrence, seasonal timing, and persistence of foraging habitats across these three decades. In the decades of the 1990s and the 2010s, prey was less abundant than in the 2000s, corresponding to reduced use of the Southeast US calving grounds in the winter, increased use of Cape Cod Bay in winter and spring, and reduced use of Roseway Basin in the fall. In the 2010s, right whale sightings increased in Southern New England and the Gulf of St. Lawrence in the spring and summer, respectively. Summertime declines in the 2010s in late‐stage copepod abundances in the Gulf of Maine and surrounding regions, as well as in the Gulf of St. Lawrence, indicate that recent increased use of the Gulf of St. Lawrence is driven by a decline in prey in traditional foraging habitats rather than by an increase in prey in the new foraging habitat. This analysis of decadal‐scale differences in right whale sightings and prey abundance is critical for redefining right whale distribution patterns for the most recent (post‐2010) decade.
Screening and Management of Dyslipidemia in Children and Adolescents

This review provides an overview of pediatric dyslipidemia emphasizing screening and treatment recommendations. The presence of risk factors for cardiovascular disease in childhood poses significant risk for the development of atherosclerotic cardiovascular disease and cardiovascular events in adulthood. While atherogenic dyslipidemia is the most common dyslipidemia seen in children and can be suspected based on the presence of risk factors (such as obesity), familial hypercholesterolemia can be found in children with no risk factors. As such, universal cholesterol screening is recommended to identify children with these disorders in order to initiate treatment and reduce the risk of future cardiovascular disease. Treatment of pediatric dyslipidemia begins with lifestyle modifications, but primary genetic dyslipidemias may require medications such as statins. As pediatric lipid disorders often have genetic or familial components, it is important that all physicians are aware that cardiovascular risk begins in childhood, and can both identify these disorders in pediatric patients and counsel their adult patients with dyslipidemia to have their children screened.
Mapping Computational Thinking Skills Through Digital Games Co-Creation Activity Amongst Malaysian Sub-urban Children

This study investigates how digital game co-creation promotes Computational Thinking (CT) skills among children in sub-urban primary schools. Understanding how CT skills can be fostered in learning programming concepts through co-creating digital games is crucial to determine instructional strategies that match the young students' interests and capacities. The empirical study has successfully produced a new checklist that can be used as a tool to describe the learning of CT skills when children co-create digital games. The checklist consists of 10 core CT skills: abstraction, decomposition, algorithmic thinking, generalisation, representation, socialisation, code literacy, automation, coordination, and debugging. Thirty-six 10–12 year-olds from sub-urban primary schools in Borneo participated in creating games in three separate eight-hour sessions. In addition, one pilot session with five participants was conducted. The game co-creation process was recorded to identify and determine how these young, inexperienced, untrained young learners collaborated while using CT skills. Analysis of their narratives while co-creating digital games revealed a pattern of using CT while developing the games. Although none of the groups demonstrated the use of all ten CTs, conclusively, all ten components of the CT were visibly present in their co-created digital games.
RNA-Seq and Iso-Seq Reveal the Important Role of COMT and CCoAOMT Genes in Accumulation of Scopoletin in Noni (Morinda citrifolia)

Scopoletin, the main component of clinical drugs and the functional component of health products, is highly abundant in noni fruit (Morinda citrifolia). Multiple enzyme genes regulate scopoletin accumulation. In the present study, differentially expressed genes of noni were analyzed by RNA sequencing (RNA-Seq) and the full-length genes by isoform-sequencing (Iso-Seq) to find the critical genes in the scopoletin accumulation mechanism pathway. A total of 32,682 full-length nonchimeric reads (FLNC) were obtained, out of which 16,620 non-redundant transcripts were validated. Based on KEGG (Kyoto Encyclopedia of Genes and Genomes) annotation and differential expression analysis, two differentially expressed genes, caffeic acid 3-O-methyltransferase (COMT) and caffeoyl-CoA O-methyltransferase (CCoAOMT), were found in the scopoletin accumulation pathway of noni. Real-time quantitative polymerase chain reaction (q-PCR), phylogenetic tree analysis, gene expression analysis, and the change in scopoletin content confirmed that these two proteins are important in this pathway. Based on these results, the current study supposed that COMT and CCoAOMT play a significant role in the accumulation of scopoletin in noni fruit, and COMT (gene number: gene 7446, gene 8422, and gene 6794) and CCoAOMT (gene number: gene 12,084) were more significant. These results provide the importance of COMT and CCoAOMT and a basis for further understanding the accumulation mechanism of scopoletin in noni.
Probabilistic Predictions Of Fatigue CrackBehaviour

It is shown that reasonable predictions of fatigue crack growth can be obtained using damage mechanics concepts. A model that considers the growth of a main crack as a sequence of failures of sub-elements along the crack path is used to perform computer simulations of crack propagation in centre notched specimens. Probabilistic criteria are introduced from the statistical analysis of S/N curves for fatigue life. Scattering of the data is reproduced in sub-elements ahead of the crack tip. The result is a set of simulations for fatigue crack propagation through the same track. In order to check the model, fatigue crack growth tests were carried out in grade II titanium sheet samples, using a servohidraulic MTS machine. The results of experimental curves are compared to those of simulated curves. The good agreement observed between the sets of curves shows the possibilities of damage mechanics to give reliable lifetime predictions. Transactions on Modelling and Simulation vol 22, © 1999 WIT Press, www.witpress. com, ISSN 1743-355X