Miracle-dz/UniFAR-FTUs huggingface dataset:
Phytochemical investigation and radical scavenging activities of Melia azedarach and its DNA protective effect in cultured lymphocytes

Abstract Context: Melia azedarach Linn (Meliaceae) is an Ayurvedic medicinal plant which is native to India. It is traditionally used for the treatment of leprosy, inflammation, scrofula, anthelmintic, antilithic, diuretic, deobstruent and cardiac disorders. Objective: To evaluate the phytochemical constituents and antioxidant activities of the ethanol leaf extract of Melia azedarach (MA) and its protective effect against H2O2-induced cellular damage in cultured lymphocytes. Materials and methods: The dose-dependent study of MA (20, 40, 60, 80, 100 µg/ml) was used to study in vitro radical scavenging assays. The effective dose of MA (60 µg/ml) was further used to study the H2O2-induced DNA damage (comet assay and DNA fragmentation assay) in cultured lymphocytes. Results: The ethanol extract of MA (20, 40, 60, 80, 100 µg/ml) exhibited a significant dose-dependent inhibition of in vitro radical scavenging assays and their corresponding IC50 values as follows: hydroxyl radical (26.50 ± 0.26 µg/ml), superoxide anion (30.00 ± 0.32 µg/ml), nitric oxide radical (48.00 ± 0.48 µg/ml), DPPH radical (30.55 ± 0.32 µg/ml) and reducing power (22.00 ± 0.22 µg/ml). The increase in the severity of DNA damage and TBARS was increased significantly (p < 0.05) at 500 µM H2O2-treated cultured lymphocytes and RBC cellular membranes. The phytochemical screening studies identified 13 chemical constituents present in the leaf extract of MA. Discussion and conclusion: The results of this study demonstrate that MA offers protection against H2O2-induced cellular damage and it can be developed as an effective antioxidant during oxidative stress.
A receding horizon approach to the multiobjective control problem

This paper deals with a multiobjective control problem for nonlinear discrete time systems. The problem consists in finding a control strategy which minimizes a number of performance indexes subject to state and control constraints. A solution to this problem through the receding horizon (RH) approach is proposed. Under standard assumptions, it is shown that the resulting control law guarantees closed-loop stability. The proposed method is also used to provide a robustly stabilizing solution to the well known H2-Hinfin control problem for a class of bounded disturbances and/or parameter uncertainties. At the end of the paper, two numeric examples are described in order to highlight the stabilizing action of the predictive control law.
Adipocyte Fatty Acid-binding Protein Modulates Inflammatory Responses in Macrophages through a Positive Feedback Loop Involving c-Jun NH2-terminal Kinases and Activator Protein-1*

Adipocyte fatty acid-binding protein (A-FABP) has emerged as an important mediator of inflammation in macrophages. Macrophage-selective ablation of A-FABP alone is sufficient to prevent the development of high cholesterol diet-induced atherosclerosis in apoE-deficient mice. However, the precise mechanisms whereby A-FABP modulates inflammation remain elusive. Here, we report that A-FABP forms a finely tuned positive loop between JNK and activator protein-1 (AP-1) to exacerbate lipopolysaccharide (LPS)-induced inflammatory responses in macrophages. Real time PCR and luciferase reporter analysis showed that LPS induced A-FABP expression through transcriptional activation. This effect was mediated by JNK, which promoted the recruitment of c-Jun to a highly conserved AP-1 consensus binding motif located within the proximal region of the A-FABP promoter. LPS-induced transactivation of the A-FABP gene was diminished by either pharmacological inhibition of JNK or knocking down c-Jun or by mutating the AP-1 recognition site within the proximal region (−122 to −116 bp) of the A-FABP promoter. Conversely, the LPS-evoked phosphorylation of JNK, activation of AP-1, and production of pro-inflammatory cytokines were markedly attenuated by pharmacological or genetic suppression of A-FABP in macrophages. Furthermore, the LPS-induced elevation in A-FABP expression could also be prevented by the selective A-FABP inhibitor BMS309403. These findings support the notion that pharmacological inhibition of A-FABP represents a valid strategy for treating inflammation-related disorders such as atherosclerosis.
The Interplay of Syntax and Morphology in Building Parsing Models for Modern Hebrew

As of yet, there is no statistical parser for Modern Hebrew (MH). Current practice in building parsing models is not immediately applicable to languages that exhibit strong interaction between syntax and morphology, e.g. Modern Hebrew, Arabic and other Semitic languages. We suggest that incorporating morphological and morphosyntactic information into the parsing model is essential for parsing Semitic languages. Using a morphological analyzer, a part-of-speech tagger, and a PCFG-based general purpose parser, we segment and parse unseen MH sentences using a small annotated corpus. The Parseval scores obtained are not comparable to those of, e.g., state-of-the-art models for English, due to remaining syntactic ambiguity and limited morphological treatment. We conjecture that adequate morphological and syntactic processing of MH should be done in a unified framework in which morphology and syntax can freely interact and share information in both directions.
Dominating induced matchings in graphs containing no long claw

An induced matching M in a graph G is dominating if every edge not in M shares exactly one vertex with an edge in M. The dominating induced matching problem (also known as efficient edge domination) asks whether a graph G contains a dominating induced matching. This problem is generally NP‐complete, but polynomial‐time solvable for graphs with some special properties. In particular, it is solvable in polynomial time for claw‐free graphs. In the present article, we provide a polynomial‐time algorithm to solve the dominating induced matching problem for graphs containing no long claw, that is, no induced subgraph obtained from the claw by subdividing each of its edges exactly once.
Significant roles of bacteriochlorophyll a supplemental to chlorophyll a in the ocean

Bacteriochlorophylla (BChla)-based phototrophy cannot be ignored in understanding of carbon cycle in the ocean. However, the role of BChla relative to chlorophylla (Chla) along environmental gradients remains unclear. On the basis of the investigations in the Pacific, Indian Oceans and the China Seas, we show that the average contribution of BChla relative to Chla is higher in open-ocean compared with shelf environments, the estimated BChla-based phototrophy could reduce respiratory organic carbon consumption of 2.4% and 5.4% of the primary productions in the shelf and oceanic waters, respectively. This suggests that BChla-based phototrophy has an important role supplemental to Chla-based photosynthesis in the ocean’s carbon cycle and would be critical for a marine region to be a sink or a source of atmospheric CO2. The ISME Journal (2010) 4, 595–597; doi:10.1038/ismej.2009. 135; published online 10 December 2009 Subject Category: microbial population and community ecology
LDIF - Linked Data Integration Framework

The LDIF - Linked Data Integration Framework can be used within Linked Data applications to translate heterogeneous data from the Web of Linked Data into a clean local target representation while keeping track of data provenance. LDIF provides an expressive mapping language for translating data from the various vocabularies that are used on the Web into a consistent, local target vocabulary. LDIF includes an identity resolution component which discovers URI aliases in the input data and replaces them with a single target URI based on user-provided matching heuristics. For provenance tracking, the LDIF framework employs the Named Graphs data model. This paper describes the architecture of the LDIF framework and presents a performance evaluation of a life science use case.
Separation method and apparatus

(57) Abstract: The present invention relates to a method and apparatus for separating a separable component from a liquid medium. The separating apparatus include those gathered with one vesicles or more adjacent cells or compartments, each cell includes a plate unit having a filter 13, an inlet 16 for supplying the liquid medium into the chamber 10 , an outlet 18 for discharging the removed substance consists of the outlet 17. for discharging permeate. Liquid medium, by conveniently formed rotor, sound waves, is preferably subjected to strong turbulence created in conjunction with ultrasound and / or electric field, thereby preventing the separable component is deposited on the filter, or substantially reduced. According to the present invention, substantially planar surface of the rotor blades facing towards the filter, one or include a plurality of zones 20, or the surface of the rotor blades facing towards the filter departing from this surface 19, small intervals of the surface and the filter wings at the inner portion of the rotor and towards the periphery of the rotor are curved so as to gradually increase, or rotor blades of the cross section of the filter parallel to the plane nature to form a surface of the S-shaped rotor S-shape is continuous is used.
Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity.

The human body contains thousands of unique cell types, each with specialized functions. Cell identity is governed in large part by gene transcription programs, which are determined by regulatory elements encoded in DNA. To identify regulatory elements active in seven cell lines representative of diverse human cell types, we used DNase-seq and FAIRE-seq (Formaldehyde Assisted Isolation of Regulatory Elements) to map "open chromatin. " Over 870,000 DNaseI or FAIRE sites, which correspond tightly to nucleosome-depleted regions, were identified across the seven cell lines, covering nearly 9% of the genome. The combination of DNaseI and FAIRE is more effective than either assay alone in identifying likely regulatory elements, as judged by coincidence with transcription factor binding locations determined in the same cells. Open chromatin common to all seven cell types tended to be at or near transcription start sites and to be coincident with CTCF binding sites, while open chromatin sites found in only one cell type were typically located away from transcription start sites and contained DNA motifs recognized by regulators of cell-type identity. We show that open chromatin regions bound by CTCF are potent insulators. We identified clusters of open regulatory elements (COREs) that were physically near each other and whose appearance was coordinated among one or more cell types. Gene expression and RNA Pol II binding data support the hypothesis that COREs control gene activity required for the maintenance of cell-type identity. This publicly available atlas of regulatory elements may prove valuable in identifying noncoding DNA sequence variants that are causally linked to human disease.
Modification of the Epoxy Resin Mechanical and Thermal Properties with Silicon Acrylate and Montmorillonite Nanoparticles

In this study we have investigated the effect of montmorillonite with alkyl quaternary ammonium salt that had been doped into the silicon acrylate (AC-Si)/ Epoxy Cresol Novolac (ECN)/ montmorillonite nano composites on structural, mechanical and thermal properties of composite samples. Moreover the effect of increase in weight percentages of fillers at 0.01, 0.02, 0.03 and 0.04 wt% on the amount of Impact and flexural strength had been investigated. Also impact and flexural strength were performed on two different systems namely (a) ECN filled nanoclay and (b) AC-Si ECN filled with nano montmorillonite as a function of clay respectively. By increase in the weight percentage of filler in the context of matrix up to the 0.03 wt%, the amount of flexural and impact strength were increased but by adding filler more that 0.03 wt%, the amount of flexural and impact strength will decrease. The resulting nanocomposites have optimal mechanical properties at 0.03 wt% montmorillonite content. Addition of The AC-Si will increase the interlamellar distance due to better dispersion of the clay within the matrix. Cross section of fracture surfaces that had been shown by SEM micrographs, specifies that, increase in viscosity had caused due to aggregation that is the main cause of fluctuation in samples properties. In addition the produced samples were characterized by X-ray diffraction (XRD) differential scanning calorimetry, Thermal gravimetric analysis, scanning electron microscopy and mechanical testing (impact and flexural).
Adaptive data parallelism for internet clients on heterogeneous platforms

Today's Internet is long past static web pages filled with HTML-formatted text sprinkled with an occasional image or animation. We have entered an era of Rich Internet Applications executed locally on Internet clients such as web browsers: games, physics engines, image rendering, photo editing, etc. Yet today's languages used to program Internet clients have limited ability to tap to the computational capabilities of the underlying, often heterogeneous, platforms. In this paper we present how a Domain Specific Language(DSL) can be integrated into ActionScript, one of the most popular scripting languages used to program Internet clients and a close cousin of JavaScript. We demonstrate how our DSL, called ASDP (ActionScript Data Parallel), can be used to enable data parallelism for existing sequential programs. We also present a prototype of a system where data parallel workloads can be executed on either CPU or a GPU, with the runtime system transparently selecting the best processing unit, depending on the type of workload as well as the architecture and current load of the execution platform. We evaluate performance of our system on a variety of benchmarks, representing different types of workloads: physics, image processing, scientific computing and cryptography.
Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression

Aims The P2Y12 antagonist ticagrelor reduces mortality in patients with acute coronary syndrome (ACS), compared with clopidogrel, and the mechanisms underlying this effect are not clearly understood. Arterial thrombosis is the key event in ACS; however, direct vascular effects of either ticagrelor or clopidogrel with focus on arterial thrombosis and its key trigger tissue factor have not been previously investigated. Methods and results Human aortic endothelial cells were treated with ticagrelor or clopidogrel active metabolite (CAM) and stimulated with tumour necrosis factor-alpha (TNF-&agr;); effects on procoagulant tissue factor (TF) expression and activity, its counter-player TF pathway inhibitor (TFPI) and the underlying mechanisms were determined. Further, arterial thrombosis by photochemical injury of the common carotid artery, and TF expression in the murine endothelium were examined in C57BL/6 mice treated with ticagrelor or clopidogrel. Ticagrelor, but not CAM, reduced TNF-&agr;-induced TF expression via proteasomal degradation and TF activity, independently of the P2Y12 receptor and the equilibrative nucleoside transporter 1 (ENT1), an additional target of ticagrelor. In C57BL/6 mice, ticagrelor prolonged time to arterial occlusion, compared with clopidogrel, despite comparable antiplatelet effects. In line with our in vitro results, ticagrelor, but not clopidogrel, reduced TF expression in the endothelium of murine arteries. Conclusion Ticagrelor, unlike clopidogrel, exhibits endothelial-specific antithrombotic properties and blunts arterial thrombus formation. The additional antithrombotic properties displayed by ticagrelor may explain its greater efficacy in reducing thrombotic events in clinical trials. These findings may provide the basis for new indications for ticagrelor.
Automated Planning Using Quantum Computation

This paper presents an adaptation of the standard quantum search technique to enable application within Dynamic Programming, in order to optimise a Markov Decision Process. This is applicable to problems arising from typical planning domains that are intractable due to computational complexity when using classical computation. The proposed method is able to balance state-space exploration with greedy selection of the local minima by setting appropriate thresholds via quantum counting. A quantum walk is used to propogate through a graphical representation of the state space.
Numerous Iron-Rich Particles Lie on the Surface of Erionite Fibers from Rome (Oregon, USA) and Karlik (Cappadocia, Turkey)

Abstract Erionite samples from Rome, Oregon (USA) and Karlik, Cappadocia (Turkey) were analyzed by environmental scanning electron microscopy (E-SEM) coupled with energy-dispersive spectroscopy (EDS) to verify the chemical composition of this mineral phase, and the presence of iron in particular. By means of backscattered electron images, a large number of particles/grains were observed on the surface of the erionite fibers from both locations. The particles were found to be micrometric on samples from Rome and submicrometric on samples from Karlik, and always lighter than the hosting crystal in appearance. In different areas of the same fiber or bundle of fibers, several EDS spectra were recorded. Iron was detected only when a light particle was lying in the path of the electron beam. Iron was never identified in the EDS spectra acquired on the flat erionite surface. The results from E-SEM/EDS were confirmed by micro-Raman spectroscopy, showing bands ascribing to hematite—Fe2O3, goethite—FeO(OH), or jarosite—KFe3 3+(SO4)2(OH)6 when the laser beam was addressed on the light particles observed on the fiber surface. The evidence that iron is on the surface of erionite fibers, rather than being part of the crystalline structure, may be relevant for the carcinogenic potential of these fibers.
ICTV Virus Taxonomy Profile: Geminiviridae

The geminiviruses are a family of small, non-enveloped viruses with single-stranded, circular DNA genomes of 2500–5200 bases. Geminiviruses are transmitted by various types of insect (whiteflies, leafhoppers, treehoppers and aphids). Members of the genus Begomovirus are transmitted by whiteflies, those in the genera Becurtovirus, Curtovirus, Grablovirus, Mastrevirus and Turncurtovirus are transmitted by specific leafhoppers, the single member of the genus Topocuvirus is transmitted by a treehopper and one member of the genus Capulavirus is transmitted by an aphid. Geminiviruses are plant pathogens causing economically important diseases in most tropical and subtropical regions of the world. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the taxonomy of the Geminiviridae which is available at www.ictv. global/report/geminiviridae.
Determination of Geometric Parameters for Stereoscopic Panorama Cameras

This paper proposes an approach for solving the parameter determination problem for a stereoscopic panorama camera. Image acquisition parameters have to be calculated under given constraints defined by application requirements, the image acquisition model, and specifications of the targeted 3D scenes. Previous studies on stereoscopic panorama imaging, such as [IYT92, MB95b, WHK99b, PPB00, SKS99, HWK01, Sei01, WP01], pay great attention on how a proposed imaging approach supports a chosen area of application. The image acquisition parameter determination problem has not yet been dealt with in these studies. The lack of guidance in selecting image acquisition parameters affects the validity of results obtained for subsequent processes [WHK00]. Our approach towards parameter determination allows to satisfying commonly demanded 3D scene visualization/reconstruction application requirements: proper scene composition in resultant images; adequate sampling at a particular scene distance; and desired stereo quality (i.e. depth levels) over a diversity of scenes of interest. The paper details the models, constraints and criteria used for solving the parameter determination problem. Some practical examples are given for demonstrating the use of the formulas derived. The study contributes to the design of stereoscopic panorama cameras as well as to manuals for on-site image acquisition. The results of our studies are also useful for camera calibration, or pose estimation in stereoscopic panoramic imaging. 1 Center for Image Technology and Robotics Tamaki Campus, The University of Auckland, Auckland, New Zealand. shoukang, fay, r.klette@auckland.ac. nz You are granted permission for the non-commercial reproduction, distribution, display, and performance of this technical report in any format, BUT this permission is only for a period of 45 (forty-five) days from the most recent time that you verified that this technical report is still available from the CITR Tamaki web site under terms that include this permission. All other rights are reserved by the author(s). Determination of Geometric Parameters for Stereoscopic Panorama Cameras Shou Kang Wei, Fay Huang and Reinhard Klette CITR, Computer Science Department, The University of Auckland Tamaki Campus, Auckland, New Zealand
Advanced Microscopy of Thermoelectric Materials

University of Wollongong Copyright Warning You may print or download ONE copy of this document for the purpose of your own research or study. The University does not authorise you to copy, communicate or otherwise make available electronically to any other person any copyright material contained on this site. You are reminded of the following: This work is copyright. Apart from any use permitted under the Copyright Act 1968, no part of this work may be reproduced by any process, nor may any other exclusive right be exercised, without the permission of the author. Copyright owners are entitled to take legal action against persons who infringe their copyright. A reproduction of material that is protected by copyright may be a copyright infringement. A court may impose penalties and award damages in relation to offences and infringements relating to copyright material. Higher penalties may apply, and higher damages may be awarded, for offences and infringements involving the conversion of material into digital or electronic form. Unless otherwise indicated, the views expressed in this thesis are those of the author and do not necessarily represent the views of the University of Wollongong.
Low-voltage low-power amplifiers

Low-voltage and low-power amplifiers are strongly limited in dynamic range (DR) and bandwidth (B). The maximum dynamic-range/supply-power ratio is restricted to DR/sub max//P/sub sup/ = /spl pi//16 kTBe by thermal noise in resistors. To obtain this maximum value, several rail-to-rail (R-R) input stages and R-R output stages biased in class-AB are designed. The maximum bandwidth/supply-power ratio is restricted to B/sub 0max//P/sub sup/ = 3/C/sub L/V/sub sup/, and B/sub 0max//P/sub sup/ = 1/120I/sup 1/2//sub D/C/sub L/V/sub sup/, respectively, for bipolar and CMOS transistors. To obtain this maximum value at a sufficient amount of low-frequency gain, several compensation structures are designed, such as parallel, Miller, and multipath nested Miller compensation. <<ETX>>