Miracle-dz/UniFAR-FTUs huggingface dataset:
Integrative and Translational Physiology : Integrative Aspects of Energy Homeostasis and Metabolic Diseases Effects of weight loss and leptin on skeletal muscle in human subjects

Kenneth M. Baldwin,* Denis R. Joanisse,* Fadia Haddad, Rochelle L. Goldsmith, Dympna Gallagher, Katherine H. Pavlovich, Elisabeth L. Shamoon, Rudolph L. Leibel, and Michael Rosenbaum Department of Physiology and Biophysics, School of Medicine, University of California at Irvine, Irvine, California; Division of Kinesiology, Laval University, Quebec, Canada; Division of Exercise Physiology; Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York; Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York; and Division of Molecular Genetics, Departments of Pediatrics and Medicine, Columbia University, New York, New York
Scenarios for system requirements traceability and testing

Scenarios in current design methodologies, provide a natural way for the users to identify the inputs and outputs of the system revolving around a particular interaction process. A scenario typically consists of a sequence of steps which captures a particular run of the system and satisfies some aspect of the requirements. In this work we add additional structure to the scenarios used in the Prometheus agent development methodology. This additional structure then facilitates both traceability and automated testing. We describe our process for mapping the scenarios and their steps to the initial detailed design, where we then maintain the traceability as the design develops. The structured action lists that we define for both scenarios and their variations provides the basis for facilitating automated testing of system behavior. We describe how we use the newly defined structure within the scenarios to facilitate testing, describing how we automate test case generation, execution and analysis.
Semiotic Dynamics for Embodied Agents

Artificial intelligence explores the many different aspects of intelligence like a meandering stream carving out rivers, lakes, and deltas in an endless magnificent landscape. Each time new vistas on intelligence open up, we build new technologies to explore them and find new types of applications. In this article, the author briefly illustrate the current study of semiotic dynamics, the resulting technologies, and the field's impact on current and future intelligent systems applications
A Bregman Divergence Optimization Framework for Ranking on Data Manifold and Its New Extensions

Recently, graph-based ranking algorithms have received considerable interests in machine learning, computer vision and information retrieval communities. Ranking on data manifold (or manifold ranking, MR) is one of the representative approaches. One of the limitations of manifold ranking is its high computational complexity (O(n3), where n is the number of samples in database). In this paper, we cast the manifold ranking into a Bregman divergence optimization framework under which we transform the original MR to an equivalent optimal kernel matrix learning problem.With this new formulation, two effective and efficient extensions are proposed to enhance the ranking performance. Extensive experimental results on two real world image databases show the effectiveness of the proposed approach.
Depression and falls among community dwelling elderly people: a search for common risk factors

Study objectives: Depression and falls are two common conditions that impair the health of older people. Both are relatively underdiagnosed and undertreated problems in primary care. The study objective was to investigate whether there was a common set of risk factors that could predict an increased risk of both falls and depression. Design: This was a cohort study drawn from a primary care clinic, with a one year follow up. Dependent measures included: reporting two or more falls in the past year and a score of 7 or over on the S-GDS (Short Geriatric Depression Scale). A parsimonious set of risk factors was selected that predicted both outcomes based on a series of discriminant function analyses. Participants and setting: The setting was a primary care clinic serving a mixed socioeconomic population, in Beer Sheva, Israel. The sample included 283 General Sick Fund members, aged 60 and over, who completed both baseline assessments and one year follow up interviews. Main results: At the one year follow up, 12% of the sample reported frequent falls in the past year and 25.5% of the sample screened positive for depressive symptoms. A set of five risk factors that included: poor self rated health, poor cognitive status, impaired ADL, two or more clinic visits in the past month, and slow walking speed (g10 seconds over five metres) was successful at discriminating between fallers and non-fallers (86% discrimination) and between those with and without depressive symptoms (76%). For every risk factor added, there was a significant increase in the proportion of respondents who had depressive symptoms. A similar result was found for falls. Conclusions: These results show that there is a common set of risk factors that increase the risk of two common outcomes in geriatric medicine, falls and depression. For a general practitioner or a geriatric physician, it might be easier to detect these risk factors than to diagnose depression or high risk for falls. When these risk factors are detected in patients the physician can then be more active in direct probing about depression and falls.
A framework for Bangla text to speech synthesis

We describe a basic framework and methodology to convert Bangla Text to Speech. Articulated words are automatically produced from Bangla input text by the methodology from the basic pronunciation of the Bangla words. The single tone syllables are considered as the fundamental units for analysis. The methodology selects phonetic units from uttered vocabulary and then combined the appropriate diphones to get the final output. The uttered syllables are selected on the basis of synthesized input text. The input text is analyzed according to the very basic grammar rules of Bangla pronunciation. Using the methodology, we developed a prototype system and the output generated from the system has been analyzed with the natural human voice.
The determinants of food choice

Health nudge interventions to steer people into healthier lifestyles are increasingly applied by governments worldwide, and it is natural to look to such approaches to improve health by altering what people choose to eat. However, to produce policy recommendations that are likely to be effective, we need to be able to make valid predictions about the consequences of proposed interventions, and for this, we need a better understanding of the determinants of food choice. These determinants include dietary components (e.g. highly palatable foods and alcohol), but also diverse cultural and social pressures, cognitive-affective factors (perceived stress, health attitude, anxiety and depression), and familial, genetic and epigenetic influences on personality characteristics. In addition, our choices are influenced by an array of physiological mechanisms, including signals to the brain from the gastrointestinal tract and adipose tissue, which affect not only our hunger and satiety but also our motivation to eat particular nutrients, and the reward we experience from eating. Thus, to develop the evidence base necessary for effective policies, we need to build bridges across different levels of knowledge and understanding. This requires experimental models that can fill in the gaps in our understanding that are needed to inform policy, translational models that connect mechanistic understanding from laboratory studies to the real life human condition, and formal models that encapsulate scientific knowledge from diverse disciplines, and which embed understanding in a way that enables policy-relevant predictions to be made. Here we review recent developments in these areas.
Is Child Like Parent? Educational Attainment and Ethnic Origin

The speed at which immigrants assimilate is the subject of debate. Human capital formation plays a major role in this discussion. We compare second generation immigrants' educational attainments to those of similarly aged natives. Evidence from German data suggests ethnicity matters: ethnic network size has a positive effect on educational attainment, and a clear pattern is exhibited between countries-of-origin and education even in the second generation. For children of the foreign-born, parental schooling plays no role in educational choices. For Germans, contrary to the literature's general findings, there is a statistically significant difference in favor of father's over mother's education.
Rapid chlorophyll a fluorescence transient of Lemna gibba leaf as an indication of light and hydroxylamine effect on photosystem II activity

Rapid chlorophyll fluorescence transient induced by saturating flash (3000 μmol of photons m^-2 s^-1) was investigated when Lemna gibba had been exposed to light (100 μmol of photons m^-2 s^-1) causing the Kautsky effect or in low light intensity unable to trigger PSII photochemistry. Measurements were made by using, simultaneously, a pulse amplitude modulated fluorometer and plant efficiency analyzer system, either on non-treated L. gibba leaf or those treated with different concentrations of hydroxylamine (1-50 mM) causing gradual inhibition of the water splitting system. When any leaf was exposed to continuous light during the Kautsky effect, a rapid fluorescence transient may reflect current activity of photosystem II within the photosystem II complex. Under those conditions, a variation of transition steps appearing over time was related to a drastic change to the photosystem II functional properties. This value indicated that the energy dissipation through non-photochemical pathways was undergoing extreme change. The change of rapid fluorescence transient, induced under continuous light, when compared to those obtained under very low light intensity, confirmed the ability of photosystem II to be capable to undergo rapid adaptation lasting about two minutes. When the water splitting system was inhibited and electron donation partially substituted by hydroxylamine, the adaptation ability of photosystem II to different light conditions was lost. In this study, the change of rapid fluorescence kinetic and transient appearing over time was shown to be a good indication for the change of the functional properties of photosystem II induced either by light or by hydroxylamine.
The role of orographic drag in modelled atmospheric circulation

Recent studies have demonstrated that the representation of orography in models is highly uncertain. Motivated by the large spread in the climatological circulation and the circulation response to climate change seen among models, the primary aim of this work is to quantify the uncertainty introduced by their representation of orography. This is done through a number of experiments using different comprehensive atmospheric models across horizontal resolutions and timescales. First, it is shown that two of the models considered are unable to maintain an equivalent total (resolved plus parameterized) orographic drag across resolutions over the Northern Hemisphere (NH) mid-latitudes, leading to systematic biases at lower climate model resolutions. The suitability of substituting one drag parameterization scheme for another is also investigated. It emerges that there is a strong regional dependence of the model error on the drag parameterization scheme employed. High-resolution global and limited area models analysed over the Himalayan Plateau are used as a proxy for the truth. The non-robustness to resolution over this region is attributed to particular components of the orographic drag parameterization scheme and its formulation. It is shown that most of the reduction in short-range forecast error that occurs with increasing resolution is due to a reduction in the parameterized orographic drag, as opposed to the addition of resolved orographic drag. Finally, the impact of the uncertainty in the parameterized orographic drag scheme on the circulation and its response to climate change is investigated. The low-level parameterized orographic drag is found to be beneficial for the modelled stationary wave field over the NH and for the jet latitude in both hemispheres. Over the NH, the amplitude of the stationary wave response to climate change across the experiments is shown to scale with the magnitude of low-level parameterized orographic drag through its influence on the present-day climatological stationary wave amplitudes.
Equivalences Among Relational Expressions

Many database queries can be formulated in terms of expressions whose operands represent tables of information (relations) and whose operators are the relational operations select, project, and join. This paper studies the equivalence problem for these relational expressions, with expression optimization in mind. A matrix, called a tableau, is proposed as a natural representative for the value of an expression. It is shown how tableaux can be made to reflect functional dependencies among attributes. A polynomial time algorithm is presented for the equivalence of tableaux that correspond to an important subset of expressions, although the equivalence problem is shown to be NP-complete under slightly more general circumstances.
Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase

Multiple human epidemiologic studies link caffeinated (but not decaffeinated) beverage intake with significant decreases in several types of cancer, including highly prevalent UV-associated skin carcinomas. The mechanism by which caffeine protects against skin cancer is unknown. Ataxia telangiectasia and Rad3-related (ATR) is a replication checkpoint kinase activated by DNA stresses and is one of several targets of caffeine. Suppression of ATR, or its downstream target checkpoint kinase 1 (Chk1), selectively sensitizes DNA-damaged and malignant cells to apoptosis. Agents that target this pathway are currently in clinical trials. Conversely, inhibition of other DNA damage response pathways, such as ataxia telangiectasia mutated (ATM) and BRCA1, promotes cancer. To determine the effect of replication checkpoint inhibition on carcinogenesis, we generated transgenic mice with diminished ATR function in skin and crossed them into a UV-sensitive background, Xpc−/−. Unlike caffeine, this genetic approach was selective and had no effect on ATM activation. These transgenic mice were viable and showed no histological abnormalities in skin. Primary keratinocytes from these mice had diminished UV-induced Chk1 phosphorylation and twofold augmentation of apoptosis after UV exposure (P = 0.006). With chronic UV treatment, transgenic mice remained tumor-free for significantly longer (P = 0.003) and had 69% fewer tumors at the end of observation of the full cohort (P = 0.019), compared with littermate controls with the same genetic background. This study suggests that inhibition of replication checkpoint function can suppress skin carcinogenesis and supports ATR inhibition as the relevant mechanism for the protective effect of caffeinated beverage intake in human epidemiologic studies.
Activity Analysis and Preliminary Inducer Screening of the Chicken DAZL Gene Promoter

This study was aimed at identifying the active control area of chicken DAZL gene core promoter, to screen optimum inducers of the DAZL gene, thus to enhance the differentiation of embryonic stem cells into spermatogonial stem cells. Fragments of chicken DAZL gene promoter were cloned into fluorescent reporter plasmids and transfected into DF-1 cells. Then Dual-Luciferase® Reporter Assay System was used to identify the activity of the DAZL gene under different inducers. Our studies showed that the DAZL core promoter region for the Suqin yellow chicken was −383 to −39 bp. The dual-luciferase® reporter showed that all-trans retinoic acid (ATRA), a retinoic acid receptor alpha agonist (tamibarotene/Am80), or estradiol (E2) could significantly enhance DAZL transcription. The in vitro inductive culture of chicken ESCs demonstrated that, with ATRA treatment, DAZL transcription peaked at 6 days and then decreased slowly; whereas, DAZL transcription was continuous and peaked at 10 days with Am80 treatment. E2 treatment significantly increased DAZL expression after 8 days. All three treatments were associated with the appearance of male germ cell (MGC)-like cells on day 10. These results provide the optimum inducer screening of the DAZL gene and lay the foundation for further screening of compounds that can induce the differentiation of ESCs into MGCs in vitro.
Design retargetable platform system for microprocessor functional test

Microprocessors are extremely versatile and complexity that present significantly test challenges. This paper describes a retargetable functional test platform system design for various microprocessors. Characterized by configurable test environment generator, retargetable assembler and strong ATPG the platform system could automatically produce different test environment and assemble out relative test codes to adapt to the microprocessor under test. Experiments show that the platform system works correctly, flexibly and efficiently.
Cytomegalovirus Pneumonia: High-Resolution CT Findings in Ten Non-AIDS Immunocompromised Patients

Objective To describe the HRCT findings of cytomegalovirus (CMV) pneumonia in non-AIDS immunocompromised patients. Materials and Methods This retrospective study involved the ten all non-AIDS immunocompromised patients with biopsy-proven CMV pneumonia and without other pulmonary infection encountered at our Medical Center between January 1997 and May 1999. HRCT scans were retrospectively analysed by two chest radiologists and decisions regarding the findings were reached by consensus. Results The most frequent CT pattern was ground-glass opacity, seen in all patients, with bilateral patchy (n = 8) and diffuse (n = 2) distribution. Other findings included poorly-defined small nodules (n = 9) and consolidation (n = 7). There was no zonal predominance. The small nodules, bilateral in eight cases and unilateral in one, were all located in the centrilobular region. Consolidation (n = 7), with patchy distribution, was bilateral in five of seven patients (71%). Pleural effusion and bilateral areas of thickened interlobular septa were seen in six patients (60%). Conclusion CMV pneumonia in non-AIDS immunocompromised patients appears on HRCT scans as bilateral mixed areas of ground-glass opacity, poorly-defined centrilobular small nodules, and consolidation. Interlobular septal thickening and pleural effusion are frequently associated.
Increased platelet aggregation and in vivo platelet activation after granulocyte colony-stimulating factor administration

Summary Granulocyte colony-stimulating factor (G-CSF) stimulates the bone marrow to produce granulocytes and stem cells and is widely used to accelerate neutrophil recovery after chemotherapy. Interestingly, specific G-CSF receptors have been demonstrated not only on myeloid cells, but also on platelets. Data on the effects of G-CSF on platelet function are limited and partly conflicting. The objective of this study was to determine the effect of G-CSF on platelet aggregation and in vivo platelet activation. Seventy-eight, healthy volunteers were enrolled into this randomised, placebo-controlled trial. Subjects received 5 μg/kg methionyl human granulocyte colony-stimulating factor (r-metHuG-CSF, filgrastim) or placebo subcutaneously for four days. We determined platelet aggregation with a whole blood impedance aggregometer with various, clinically relevant platelet agonists (adenosine diphosphate [ADP], collagen, arachidonic acid [AA], ristocetin and thrombin receptor activating peptide 6 [TRAP]). Filgrastim injection significantly enhanced ADP (+40%), collagen (+60%) and AA (+75%) -induced platelet aggregation (all p<0.01 as compared to placebo and p<0.001 as compared to baseline). In addition, G-CSF enhanced ristocetin-induced platelet aggregation (+18%) whereas TRAP-induced platelet aggregation decreased slightly (-14%) in response to filgrastim. While baseline aggregation with all agonists was only slightly but insignificantly higher in women than in men, this sex difference was enhanced by G-CSF treatment, and became most pronounced for ADP after five days (p<0.001). Enhanced platelet aggregation translated into a 75% increase in platelet activation as measured by circulating soluble P-selectin. G-CSF enhances platelet aggregation and activation in humans. This may put patients suffering from cardiovascular disease and cancer at risk for thrombotic events.
Metabolomic analysis of human vitreous humor differentiates ocular inflammatory disease

Purpose Vitreoretinal disorders lack specific biomarkers that define either disease type or response to treatment. We have used NMR-based metabolomic analysis of human vitreous humor to assess the applicability of this approach to the study of ocular disease. Methods Vitreous samples from patients with a range of vitreoretinal disorders were subjected to high-resolution 1H-nuclear magnetic resonance spectroscopy (NMR). Good quality spectra were derived from the vitreous samples, and the profiles were analyzed by three different methods. Results Principal component analysis (PCA) showed a wide dispersal of the different clinical conditions. Partial least squares discriminant analysis (PLS-DA) was used to define differences between lens-induced uveitis (LIU) and chronic uveitis (CU) and could distinguish between these conditions with a sensitivity of 78% and specificity of 85%. A genetic algorithm coupled with multivariate classification identified a small number of spectral components that showed clear discrimination between LIU and CU samples with sensitivity and specificity >90%. Assignment of specific resonances indicated that some metabolites involved in the arginase pathway were significantly more abundant in LIU than CU. Conclusion The discrimination we observed based on PCA, PLS-DA, and multivariate variable selection analysis of the NMR spectra suggests that a complex mix of metabolites are present in vitreous fluid of different uveitic conditions as a result of the disease process. Collectively the data demonstrates the efficacy of metabolomic analysis to distinguish between ocular inflammatory diseases.
Ventricular septal defect and bivalvular endocarditis

Abstract A 63-year-old man presented with generalized fatigue, chills, malaise, dyspnea, intermittent fevers, and 50-pound weight loss of 4 months′ duration. Blood cultures were positive for pan-sensitive Streptococcus anginosus. Transesophageal echocardiography showed an 11 mm × 3 mm mobile mass attached to the mitral valve, a 16 mm × 16 mm mobile mass attached to the pulmonary valve, and a small membranous ventricular septal defect. The patient received 12 weeks of intravenous (IV) antibiotics with eventual resolution of the masses. Multi-valve endocarditis involving both the left and right chambers is rarely reported without prior history of IV drug use or infective endocarditis. Our case emphasizes the importance of careful assessment for ventricular septal defects or extra-cardiac shunts in individuals who present with simultaneous right and left-sided endocarditis.
Causal observability of nonlinear time-delay systems with unknown inputs

This paper investigates the problem of causal observability of the states and unknown inputs of nonlinear time-delay systems. Using the theory of non-commutative rings, the nonlinear time-delay system is transformed into a suitable canonical form to solve the problem. A necessary and sufficient condition is given to guarantee the existence of a change of coordinate leading to such a form. Then, algorithms are provided to check the possibility of obtaining causal estimations of the states and unknown inputs for the studied systems.