Miracle-dz/UniFAR-FTUs huggingface dataset:
B7-H1 Influences the Accumulation of Virus-Specific Tissue Resident Memory T Cells in the Central Nervous System

Therapies that target the PD-1/B7-H1 axis have revolutionized cancer treatment, yet precise knowledge of how this pathway provides benefit continues to evolve. Here, we report a novel role for the immune checkpoint ligand B7-H1 in the accumulation of tissue-resident memory CD8+ T-cells (TRM). After intracranial infection, Theiler’s murine encephalomyelitis virus (TMEV) generates TRM that are maintained in the central nervous system (CNS) tissues of B7-H1WT animals. Although no differences in acute T-cell responses between B7-H1WT and B7-H1KO are observed, at long-term periods post-infection the maintenance of CD8+ TRM is diminished in B7-H1KO animals. This is accompanied by redistribution of the resident CD8+ population from primarily CD103+ TRM to a diminished population of TRM and a preponderance of non-specified PD-1+ CD103− CD8+ T-cells. T-cell transfer studies demonstrate that host B7-H1 is necessary for maintaining TRM and limiting accumulation of PD-1+ CD103− CD8+ T-cells. The lack of host B7-H1 results in compromised control of a heterologous virus re-challenge demonstrating a functional defect in TRM mediated virus control. This study reveals a new role for B7-H1 in TRM and pro-inflammatory PD-1+ CD103− CD8+ T-cell accumulation in the CNS and gives insight for using B7-H1/PD-1 blockade in modulating long-term T-cell protection.
Vascular endothelial senescence: from mechanisms to pathophysiology.

Most mitotically competent mammalian cell types can react to stress by undergoing a phenotypically distinctive and permanent form of growth arrest called "cellular senescence. " This response has been extensively characterized in cell culture and more recently it has been found to occur also in vivo in a number of tissues. In this review I will present the case for the occurrence of senescence in the vascular endothelium. I will also discuss the mechanisms and factors that modulate endothelial cell replicative capacity and the onset of senescence. Finally, I will examine the senescent phenotype and its possible consequences for the development and progression of vascular diseases.
Unbiased and Mobile Gait Analysis Detects Motor Impairment in Parkinson's Disease

Motor impairments are the prerequisite for the diagnosis in Parkinson's disease (PD). The cardinal symptoms (bradykinesia, rigor, tremor, and postural instability) are used for disease staging and assessment of progression. They serve as primary outcome measures for clinical studies aiming at symptomatic and disease modifying interventions. One major caveat of clinical scores such as the Unified Parkinson Disease Rating Scale (UPDRS) or Hoehn&Yahr (H&Y) staging is its rater and time-of-assessment dependency. Thus, we aimed to objectively and automatically classify specific stages and motor signs in PD using a mobile, biosensor based Embedded Gait Analysis using Intelligent Technology (eGaIT). eGaIT consist of accelerometers and gyroscopes attached to shoes that record motion signals during standardized gait and leg function. From sensor signals 694 features were calculated and pattern recognition algorithms were applied to classify PD, H&Y stages, and motor signs correlating to the UPDRS-III motor score in a training cohort of 50 PD patients and 42 age matched controls. Classification results were confirmed in a second independent validation cohort (42 patients, 39 controls). eGaIT was able to successfully distinguish PD patients from controls with an overall classification rate of 81%. Classification accuracy increased with higher levels of motor impairment (91% for more severely affected patients) or more advanced stages of PD (91% for H&Y III patients compared to controls), supporting the PD-specific type of analysis by eGaIT. In addition, eGaIT was able to classify different H&Y stages, or different levels of motor impairment (UPDRS-III). In conclusion, eGaIT as an unbiased, mobile, and automated assessment tool is able to identify PD patients and characterize their motor impairment. It may serve as a complementary mean for the daily clinical workup and support therapeutic decisions throughout the course of the disease.
Streamwise Feature Selection

In streamwise feature selection, new features are sequentially considered for addition to a predictive model. When the space of potential features is large, streamwise feature selection offers many advantages over traditional feature selection methods, which assume that all features are known in advance. Features can be generated dynamically, focusing the search for new features on promising subspaces, and overfitting can be controlled by dynamically adjusting the threshold for adding features to the model. In contrast to traditional forward feature selection algorithms such as stepwise regression in which at each step all possible features are evaluated and the best one is selected, streamwise feature selection only evaluates each feature once when it is generated. We describe information-investing and α-investing, two adaptive complexity penalty methods for streamwise feature selection which dynamically adjust the threshold on the error reduction required for adding a new feature. These two methods give false discovery rate style guarantees against overfitting. They differ from standard penalty methods such as AIC, BIC and RIC, which always drastically over- or under-fit in the limit of infinite numbers of non-predictive features. Empirical results show that streamwise regression is competitive with (on small data sets) and superior to (on large data sets) much more compute-intensive feature selection methods such as stepwise regression, and allows feature selection on problems with millions of potential features.
F-Box Proteins in Rice. Genome-Wide Analysis, Classification, Temporal and Spatial Gene Expression during Panicle and Seed Development, and Regulation by Light and Abiotic Stress1[W][OA]

F-box proteins constitute a large family in eukaryotes and are characterized by a conserved F-box motif (approximately 40 amino acids). As components of the Skp1p-cullin-F-box complex, F-box proteins are critical for the controlled degradation of cellular proteins. We have identified 687 potential F-box proteins in rice (Oryza sativa), the model monocotyledonous plant, by a reiterative database search. Computational analysis revealed the presence of several other functional domains, including leucine-rich repeats, kelch repeats, F-box associated domain, domain of unknown function, and tubby domain in F-box proteins. Based upon their domain composition, they have been classified into 10 subfamilies. Several putative novel conserved motifs have been identified in F-box proteins, which do not contain any other known functional domain. An analysis of a complete set of F-box proteins in rice is presented, including classification, chromosomal location, conserved motifs, and phylogenetic relationship. It appears that the expansion of F-box family in rice, in large part, might have occurred due to localized gene duplications. Furthermore, comprehensive digital expression analysis of F-box protein-encoding genes has been complemented with microarray analysis. The results reveal specific and/or overlapping expression of rice F-box protein-encoding genes during floral transition as well as panicle and seed development. At least 43 F-box protein-encoding genes have been found to be differentially expressed in rice seedlings subjected to different abiotic stress conditions. The expression of several F-box protein-encoding genes is also influenced by light. The structure and function of F-box proteins in plants is discussed in light of these results and the published information. These data will be useful for prioritization of F-box proteins for functional validation in rice.
Large Brains in Autism: The Challenge of Pervasive Abnormality

The most replicated finding in autism neuroanatomy—a tendency to unusually large brains—has seemed paradoxical in relation to the specificity of the abnormalities in three behavioral domains that define autism. We now know a range of things about this phenomenon, including that brains in autism have a growth spurt shortly after birth and then slow in growth a few short years afterward, that only younger but not older brains are larger in autism than in controls, that white matter contributes disproportionately to this volume increase and in a nonuniform pattern suggesting postnatal pathology, that functional connectivity among regions of autistic brains is diminished, and that neuroinflammation (including microgliosis and astrogliosis) appears to be present in autistic brain tissue from childhood through adulthood. Alongside these pervasive brain tissue and functional abnormalities, there have arisen theories of pervasive or widespread neural information processing or signal coordination abnormalities (such as weak central coherence, impaired complex processing, and underconnectivity), which are argued to underlie the specific observable behavioral features of autism. This convergence of findings and models suggests that a systems- and chronic disease-based reformulation of function and pathophysiology in autism needs to be considered, and it opens the possibility for new treatment targets.
Signs of appeasement: evidence for the distinct displays of embarrassment, amusement, and shame

According to appeasement hypotheses, embarrassment should have a distinct nonverbal display that is more readily perceived when displayed by individuals from lower status groups. The evidence from 5 studies supported these two claims. The nonverbal behavior of embarrassment was distinct from a related emotion (amusement), resembled the temporal pattern of facial expressions of emotion, was uniquely related to self-reports of embarrassment, and was accurately identified by observers who judged the spontaneous displays of various emotions. Across the judgment studies, observers were more accurate and attributed more emotion to the embarrassment displays of female and AfricanAmerican targets than those of male and Caucasian targets. Discussion focused on the universality and appeasement function of the embarrassment display. Since universal facial expressions of a limited set of emotions were first documented (Ekman & Friesen, 1971; Ekman, Sorenson, & Friesen, 1969; Izard, 1971), sparse attention has been given to facial expressions of other emotions. The resulting lacuna in the field—that the emotions with identified displays are fewer (7 to 10) than the states that lay people (Fehr & Russell, 1984) and emotion theorists (Ekman, 1992; Izard, 1977; Tomkins, 1963, 1984) label as emotions—presents intriguing possibilities. Displays of other emotions may be blends of other emotional displays, unidentifiable, or may await discovery.
Priming Past the Primary: Mass Media, Issue Salience and Candidate Evaluation in a Race for Governor

Past research indicates that voters have begun to rely less on party affiliations and more on candidates' images and positions on issues in making voting decisions. Through using the mass media, voters can learn about issues and candidates, and form images of the candidates. Our study concerns the effects of mass mediated election news, and of political advertising, on voters' choice of candidates. In particular, we examined the roles of media agenda-setting and priming, and of negative NOT THE PUBLISHED VERSION; this is the author’s final, peer-reviewed manuscript. The published version may be accessed by following the link in the citation at the bottom of the page. Current Politics and Economics of the United States, Canada, and Mexico, Vol. 1, No. 1 (1993): pg. 101-119. Publisher Link. This article is © Nova Science Publishers and permission has been granted for this version to appear in ePublications@Marquette. Nova Science Publishers does not grant permission for this article to be further copied/distributed or hosted elsewhere without the express permission from Nova Science Publishers. 2 political advertising, in the development of voter’s evaluations of candidates. An important trend in agenda-setting research is to look beyond issue saliences as dependent variables to determine what relationships issue saliences have with other phenomena, such as public opinion and voting choice. Research into "priming" indicates that the issues and other aspects of political life (e.g., a candidate's character) that become salient in an election are used by voters to evaluate candidates for public office, and therefore indirectly affect voting behavior. An analysis of a sample survey of eligible voters in the 1990 race for Wisconsin governor found that attention to news accounts of the election is associated with higher levels of salience given some issues in that election. In line with the "priming" model, issue salience had some, although modest, relationship to evaluation of the candidates. Political commercials, including negative ads, appeared to affect candidate evaluations more directly, while news media appeared to work through issue salience to affect evaluations of candidates. Some evidence was found of a ''boomerang" effect of negative advertising in this campaign. Identification with political parties had only a small direct relationship to voting intention. Instead, this identification appears to work along with the direct and indirect effects of communication variables to influence candidate evaluation, which then appears to affect voting choice.
On the Processing of Very High Resolution Spaceborne SAR Data

This paper addresses several important aspects that need to be considered for the processing of spaceborne synthetic aperture radar (SAR) data with resolutions in the decimeter range. In particular, it will be shown how the motion of the satellite during the transmission/reception of the chirp signal and the effect of the troposphere deteriorate the impulse response function if not properly considered. Further aspects that have been investigated include the curved orbit, the array pattern for electronically steered antennas, and several considerations within the processing itself. For each aspect, a solution is proposed, and the complete focusing methodology is expounded and validated using simulated point targets and staring spotlight data acquired by TerraSAR-X with 16-cm azimuth resolution and 300-MHz range bandwidth.
Dynamic modelling of supercapacitor using artificial neural network technique

Because of the complex dynamic behavior of supercapacitor, its modeling must be based on parallel, distributed structures (each component has to represent a model of activity, distributed on many processing units), with learning capacity. For this purpose, the paper proposes a new feed forward artificial neural network structure with two hidden layers and with backpropagation training. The neural network provides, after activation, training, testing and reinitializing, output values with a total correlation of 0, 9426 compared with target values.
The Development and Evolution of the Criteria for a Newly Proposed Diagnosis for DSM-5: Hypersexual Disorder

This manuscript discusses the empirical foundations for the initial development and subsequent revisions of the diagnostic criteria for Hypersexual Disorder (HD). Historically, DSM manuals are constructed using behaviors descriptors or symptoms (A Criteria) and a threshold (Criterion B) characterizing distress or impairment associated with the consequences of Criterion A behaviors. In addition, many psychiatric disorders, like HD, are additionally defined by adding “exclusionary” criteria (e.g., Criterion C and D) to reduce the unintended consequences associated false positive or “over-diagnosis. ” The definition and criteria associated with Hypersexual Disorder evolved over 3 years and its development was modified by professional discourse, published critiques, input by educated lay persons, as well as, a rigorous internal review by committees associated with the American Psychiatric Association's DSM-5 project. Although ultimately rejected for placement in DSM-5, there have been substantive gains associated with this proposal including a successful multicenter field trial as well as continued research in the U.S. and Europe incorporating the operational definition and rating instruments associated with Hypersexual Disorder. Suggested areas for further research of HD are recommended so that this proposal can continue to be taken seriously by researchers as well as clinicians.
Aneurysmal Subarachnoid Hemorrhage

Aneurysmal subarachnoid hemorrhage (SAH) is a worldwide health burden with high fatality and permanent disability rates. The overall prognosis depends on the volume of the initial bleed, rebleeding, and degree of delayed cerebral ischemia (DCI). Cardiac manifestations and neurogenic pulmonary edema indicate the severity of SAH. The International Subarachnoid Aneurysm Trial (ISAT) reported a favorable neurological outcome with the endovascular coiling procedure compared with surgical clipping at the end of 1 year. The ISAT trial recruits were primarily neurologically good grade patients with smaller anterior circulation aneurysms, and therefore the results cannot be reliably extrapolated to larger aneurysms, posterior circulation aneurysms, patients presenting with complex aneurysm morphology, and poor neurological grades. The role of hypothermia is not proven to be neuroprotective according to a large randomized controlled trial, Intraoperative Hypothermia for Aneurysms Surgery Trial (IHAST II), which recruited patients with good neurological grades. Patients in this trial were subjected to slow cooling and inadequate cooling time and were rewarmed rapidly. This methodology would have reduced the beneficial effects of hypothermia. Adenosine is found to be beneficial for transient induced hypotension in 2 retrospective analyses, without increasing the risk for cardiac and neurological morbidity. The neurological benefit of pharmacological neuroprotection and neuromonitoring is not proven in patients undergoing clipping of aneurysms. DCI is an important cause of morbidity and mortality following SAH, and the pathophysiology is likely multifactorial and not yet understood. At present, oral nimodipine has an established role in the management of DCI, along with maintenance of euvolemia and induced hypertension. Following SAH, hypernatremia, although less common than hyponatremia, is a predictor of poor neurological outcome.
Home enteral nutrition in children: a 10 year experience with 304 pediatric patients.

BACKGROUND & AIMS Home enteral nutrition is used increasingly in pediatric populations. Our objective was to describe the profile of pediatric patients requiring this treatment. MATERIAL AND METHODS All patients under 18 years old requiring treatment with home enteral nutrition between January 1995 and December 2004 were analyzed retrospectively. RESULTS 304 patients were studied (157 boys). The mean age at the start of treatment was 4.02 ± 4.09 years, median of 2.5 years; 28% of all patients were under 1 year. The main indications were oncological disease in 91 patients (29.9%) and digestive diseases in 84 (27.6%). There were significant differences depending on the clinical diagnosis for the start age, type of access, infusion regime and formula prescribed. Nutrients were delivered by nasogastric tube in 218 patients (71.7%). Overnight enteral nutrition was the preferred infusion regime in 155 patients (51%). Adult or pediatric polymeric formulas were mostly prescribed in 190 patients (62.5%). The mean treatment duration was 306 ± 544 days. CONCLUSION In our series, enteral support usually begins at an early age. Its characteristics varied depending on patient pathology. Knowledge of the pediatric patient profile is important to design the most effective strategy for home enteral nutrition.
HIV type 1 (HIV-1) proviral reservoirs decay continuously under sustained virologic control in HIV-1-infected children who received early treatment.

BACKGROUND Early initiation of combination antiretroviral therapy (cART) to human immunodeficiency virus type 1 (HIV-1)-infected infants controls HIV-1 replication and reduces mortality. METHODS Plasma viremia (lower limit of detection, <2 copies/mL), T-cell activation, HIV-1-specific immune responses, and the persistence of cells carrying replication-competent virus were quantified during long-term effective combination antiretroviral therapy (cART) in 4 perinatally HIV-1-infected youth who received treatment early (the ET group) and 4 who received treatment late (the LT group). Decay in peripheral blood mononuclear cell (PBMC) proviral DNA levels was also measured over time in the ET youth. RESULTS Plasma viremia was not detected in any ET youth but was detected in all LT youth (median, 8 copies/mL; P = .03). PBMC proviral load was significantly lower in ET youth (median, 7 copies per million PBMCs) than in LT youth (median, 181 copies; P = .03). Replication-competent virus was recovered from all LT youth but only 1 ET youth. Decay in proviral DNA was noted in all 4 ET youth in association with limited T-cell activation and with absent to minimal HIV-1-specific immune responses. CONCLUSIONS Initiation of early effective cART during infancy significantly limits circulating levels of proviral and replication-competent HIV-1 and promotes continuous decay of viral reservoirs. Continued cART with reduction in HIV-1 reservoirs over time may facilitate HIV-1 eradication strategies.
Impact of radiation therapy on survival in patients with triple-negative breast cancer

Triple-negative breast cancer (TNBC) has a poorer prognosis compared with other sub-groups. In the current study, survival associated with locoregional treatment of females with TNBC was investigated. Specifically, 468 patients with stage I–III TNBC treated between 2002 and 2009 were identified. Data included patient and tumor characteristics, treatment received and survival. Data were compared using χ2 and Fisher’s exact tests, as well as MANOVA. Kaplan-Meier curves were generated. The study cohort had a mean age of 54±13 years old with a mean follow-up period of 51±21 months. Of 468 patients, 249 (53%) underwent lumpectomy, 63 (14%) underwent simple mastectomy (SM) and 156 (33%) underwent modified radical mastectomy (MRM). Overall, 263 (56%) received adjuvant radiation, including 178/249 (71%) following lumpectomy, 13/63 (21%) following SM and 72/156 (46%) following MRM (P<0.0001). Following control for potential confounders in univariate tests, adjuvant radiation was associated with improved overall survival in the total cohort (HR, 0.46; 95% CI, 0.31–0.68; P=0.0001). When comparing survival by surgical type, receipt of adjuvant radiation significantly improved survival in the lumpectomy group (HR, 0.30; 95% CI, 0.16–0.58; P=0.0004), but was not associated with improved survival in the SM group (HR, 0.38; 95% CI, 0.05–3.04; P=0.36) or in the MRM group (HR, 0.79; 95% CI, 0.46–1.34; P=0.38). The survival benefit of adjuvant radiation in these TNBC patients is attributed to those undergoing breast-conserving therapy. There was no benefit in either mastectomy group. These data warrant validation from prospective trials, in order to develop tailored locoregional treatment for patients with TNBC.