Miracle-dz/UniFAR-FTUs huggingface dataset:
Extramedullary Imaging Manifestations of Leukemia/Lymphoblastic Lymphoma in Pediatrics: A Case Series

Leukemia is the most common childhood malignancy and often presents with nonspecific symptoms. Occasionally, it presents with extramedullary manifestations, which have been more frequent in cases of myeloid lineage or T cells. However, precursor B-cell leukemia/lymphoblastic lymphoma can also have extramedullary manifestations in some patients. Describing certain clinical features along with diagnostic imaging can establish a presentation pattern and suggest a diagnosis in the pediatric population. Herein, we present a series of four patients with extramedullary manifestations of B-cell lymphoblastic leukemia, describing their clinical imaging and histopathological characteristics.
Morphological and Physiological Characteristics of the Serotonin-Immunoreactive Neuron in the Antennal Lobe of the Male Oriental Tobacco Budworm, Helicoverpa assulta

We have characterized, by intracellular recording and staining combined with immunocytochemistry, a serotonin-immunoreactive neuron in the central olfactory pathway of the male moth Helicoverpa assulta. The neuron joins the unique category of so-called SI antennal-lobe neurons, previously described in several insect species. In similarity with that originally discovered in the sphinx moth Manduca sexta, the neuron identified here has a large soma located posteriorly in the lateral cell cluster of the antennal lobe and an unbranched neurite projecting into the ipsilateral protocerebrum via the inner antennocerebral tract. After bypassing the central body, the axon crosses the midline and extends through the corresponding antennocerebral tract to the contralateral antennal lobe where it innervates the entire assembly of glomeruli including the male-specific macroglomerular complex. The neuron arborizes into several fine branches in bilateral protocerebral regions anterior to the calyces of the mushroom bodies, particularly on the contralateral side. The physiology of the neuron revealed 2 distinctly different spiking amplitudes, 1 small showing a relatively high spontaneous activity and 1 large showing low activity. The small-amplitude spikes displayed increased frequency when pheromones and plant odors were blown over the antenna. The large-amplitude spikes, which had an unusually long duration, showed no observable responses.
A CMOS Temperature Sensor Circuit

A supply voltage (V DD ) independent temperature sensor circuit, which can be realized by the optimum combination of three current modes of n-MOSFETs including the subthreshold current using the feedback scheme from the temperature dependent voltage (V TD ) output to the gates of three n-MOSFETs, was proposed and fabricated by a standard 1. 2μm n-well CMOS process. The circuit consists of only 17 MOSFETs without high resistors resulting in a small die area of 0.18 mm 2 . The temperature coefficient TC of the sensor circuit can be controlled by the channel length ratio L4/L 3 of two n-MOSFETs. The average temperature sensor voltage V TS and its typical TC are 1.77 V at V DD = 5.0 V (20°C) and 5.1 mV/°C for V DD = 5.0 ± 1.0 V in the temperature range of -20-100°C in case of L4/L3 = 9, respectively.
University of Birmingham Feasibility and Preliminary Efficacy of Visual Cue Training to Improve Adaptability of Walking after Stroke

Given the importance of vision in the control of walking and evidence indicating varied practice of walking improves mobility outcomes, this study sought to examine the feasibility and preliminary efficacy of varied walking practice in response to visual cues, for the rehabilitation of walking following stroke. This 3 arm parallel, multi-centre, assessor blind, randomised control trial was conducted within outpatient neurorehabilitation services severe visual impairments Intervention and mobility and balance were before randomisation, post-intervention and at four weeks follow-up.
Coupling electrokinetics and iron nanoparticles for the remediation of contaminated soils

Fundacao para a Ciencia e a Tecnologia - PTDC/AGR-­AAM/101643/2008 NanoDC ; SFRH/BD/76070/2011 ; FP7-­PEOPLE-­IRSES-­2010-­269289-­ ELECTROACROSS
DISCOVERY OF AN UNIDENTIFIED FERMI OBJECT AS A BLACK WIDOW-LIKE MILLISECOND PULSAR

The Fermi γ-ray Space Telescope has revolutionized our knowledge of the γ-ray pulsar population, leading to the discovery of almost 100 γ-ray pulsars and dozens of γ-ray millisecond pulsars (MSPs). Although the outer-gap model predicts different sites of emission for the radio and γ-ray pulsars, until now all of the known γ-ray MSPs have been visible in the radio. Here we report the discovery of a “radio-quiet” γ-ray-emitting MSP candidate by using Fermi, Chandra, Swift, and optical observations. The X-ray and γ-ray properties of the source are consistent with known γ-ray pulsars. We also found a 4.63 hr orbital period in optical and X-ray data. We suggest that the source is a black widow-like MSP with a ∼0.1 M☉ late-type companion star. Based on the profile of the optical and X-ray light curves, the companion star is believed to be heated by the pulsar while the X-ray emissions originate from pulsar magnetosphere and/or from intrabinary shock. No radio detection of the source has been reported yet, and although no γ-ray/radio pulsation has been found we estimate that the spin period of the MSP is ∼3–5 ms based on the inferred γ-ray luminosity.
A systematic review and meta-analysis

Background: It is known to all that the incidence of insomnia is becoming higher and higher with the increase of people’s life stress. To some extent, it has brought about bad effects on people’s life, work, study, and health, such as mental exhaustion, low work efficiency, and mood irritability. Now there are medications and non-medications methods for insomnia. As one of the treatments for insomnia, western medicine is to prolong the sleeping time and improve the anxious mood. However, taking western medicine to treat insomnia can also be accompanied by some adverse reactions at the same time, such as drug dependence, an allergic reaction, and so on. Traditional Chinese medicine therapy is based on syndrome differentiation and holistic concept. Shumian capsules (SM) are a kind of proprietary Chinese medicine for insomnia, which have the effect of relieving depression and calming the mind. But there are no studies on the efficacy and safety of SM in the treatment of insomnia. Therefore, I will provide a systematic review and metaanalysis to evaluate the efficacy and safety of SM for insomnia. Methods:All the studies searched were from PubMed, EMBASE,Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure, and WanFang databases, and the studies types included in the analysis were all randomized controlled trials. All the retrieval contents were completed independently by 2 researchers, and a third reviewer would be involved when there existed any disagreement. The eligible studies were screened out according to the inclusion criteria and exclusion criteria, and some useful information was extracted andmade into a feature table, including the year of the included studies, the age, and disease course of the participants in the studies and intervention methods, etc. Cochrane risk-of-bias tool was used to evaluate the quality of literature and meta-analysis was conducted by RevMan 5.4 software. Results: A total of 9 articles including 709 participants were included in the study after screening out. The primary outcomes of statistical analysis were cure rate and total effective rate, while the secondary outcomes included Pittsburgh sleep quality index score and incidence of adverse reactions. The results showed that Pittsburgh sleep quality index score of the SM group and Western medicine group were statistically significant (MD=–0.50, 95% confidence interval [CI]= [–0.78, –0.22], P= .0005). The total effective rate of the SM group was slightly higher than that of theWestern medicine group, but there was no statistical significance (relative risk [RR]=1.03, 95% CI= [0.95,1.13], P= .43). Conclusion: This meta-analysis provides evidence for the efficacy and safety of SM in the treatment of insomnia, and provides a new idea for the clinical treatment of insomnia. But more research is needed to support further evidence. Abbreviations: CI= confidence interval, PSQI= Pittsburgh sleep quality index, RCTs= randomized controlled trials, RR= relative risk, SM = Shumian capsules, TCM = traditional Chinese medicine.
Signing up for Projects

This list is designed to help you match your interests with a potential supervisor. You do not need to register your project formally until Week 3 of the Autumn semester 2011/12, but it is helpful to many students to have this list now, to enable them to talk to potential supervisors and agree on a project choice before the start of the next academic year. It is up to you to find a supervisor. Contact details of each supervisor are given here to allow you to email or arrange meetings.
Voluntary counselling and testing: uptake, impact on sexual behaviour, and HIV incidence in a rural Zimbabwean cohort

Objectives:To examine the determinants of uptake of voluntary counselling and testing (VCT) services, to assess changes in sexual risk behaviour following VCT, and to compare HIV incidence amongst testers and non-testers. Methods:Prospective population-based cohort study of adult men and women in the Manicaland province of eastern Zimbabwe. Demographic, socioeconomic, sexual behaviour and VCT utilization data were collected at baseline (1998–2000) and follow-up (3 years later). HIV status was determined by HIV-1 antibody detection. In addition to services provided by the government and non-governmental organizations, a mobile VCT clinic was available at study sites. Results:Lifetime uptake of VCT increased from under 6% to 11% at follow-up. Age, increasing education and knowledge of HIV were associated with VCT uptake. Women who took a test were more likely to be HIV positive and to have greater HIV knowledge and fewer total lifetime partners. After controlling for demographic characteristics, sexual behaviour was not independently associated with VCT uptake. Women who tested positive reported increased consistent condom use in their regular partnerships. However, individuals who tested negative were more likely to adopt more risky behaviours in terms of numbers of partnerships in the last month, the last year and in concurrent partnerships. HIV incidence during follow-up did not differ between testers and non-testers. Conclusion:Motivation for VCT uptake was driven by knowledge and education rather than sexual risk. Increased sexual risk following receipt of a negative result may be a serious unintended consequence of VCT. It should be minimized with appropriate pre- and post-test counselling.
A survey of multi-source energy harvesting systems

Energy harvesting allows low-power embedded devices to be powered from naturally-ocurring or unwanted environmental energy (e.g. light, vibration, or temperature difference). While a number of systems incorporating energy harvesters are now available commercially, they are specific to certain types of energy source. Energy availability can be a temporal as well as spatial effect. To address this issue, ‘hybrid’ energy harvesting systems combine multiple harvesters on the same platform, but the design of these systems is not straight-forward. This paper surveys their design, including trade-offs affecting their efficiency, applicability, and ease of deployment. This survey, and the taxonomy of multi-source energy harvesting systems that it presents, will be of benefit to designers of future systems. Furthermore, we identify and comment upon the current and future research directions in this field.
Evaluation of the Adherence to Continuous Glucose Monitoring in the Management of Type 1 Diabetes Patients on Sensor-Augmented Pump Therapy: The SENLOCOR Study.

BACKGROUND Continuous glucose monitoring (CGM) and sensor-augmented pump (SAP) therapy improve glucose control provided good adherence. In France, not only diabetologists, nurses, and dieticians but also nurses employed by homecare providers (HCPNs) are together involved in the initiation and/or follow-up of continuous subcutaneous insulin injection (CSII) and SAP training. The SENLOCOR Study is an observational study designed to assess SAP adherence over 6 months (primary objective). Secondary objectives included the impact of SAP on metabolic control and patients' satisfaction. MATERIALS AND METHODS CGM initiation (M0) was performed within 3 months after CSII. CGM adherence, defined by sensor wear >70% of the time, glycated hemoglobin (HbA1c) levels, and satisfaction questionnaires were collected at inclusion and at 3 (M3) and 6 (M6) months. RESULTS The analysis population was 234 patients, including 27 children. Of the physicians, 88.0% were involved in SAP education for the whole cohort (median time, 45 min), whereas HCPNs were involved in CGM training for 190 patients (81.2%) (median time: at M0, 156 min; at M3, 20 min). Good adherence was obtained in 86.1% (M0-M3) and 68.9% (M3-M6) of the patients. The HbA1c level decreased from 8.16 ± 1.35% (M0) to 7.67 ± 1.01% (M6) in 189 patients (change, -0.48%; 95% confidence interval, -0.64, -0.33). The percentage of patients who experienced severe hypoglycemia decreased from 20.7% (M0) to 13.6% (M3) and 13.3% (M6). Satisfaction scores were high. CONCLUSIONS In patients with type 1 diabetes, a 6-month training on SAP involving a multidisciplinary team, and especially HCPNs, improved metabolic control with a high level of adherence and satisfaction.
Volume Analysis Using Multimodal Surface Similarity

The combination of volume data acquired by multiple modalities has been recognized as an important but challenging task. Modalities often differ in the structures they can delineate and their joint information can be used to extend the classification space. However, they frequently exhibit differing types of artifacts which makes the process of exploiting the additional information non-trivial. In this paper, we present a framework based on an information-theoretic measure of isosurface similarity between different modalities to overcome these problems. The resulting similarity space provides a concise overview of the differences between the two modalities, and also serves as the basis for an improved selection of features. Multimodal classification is expressed in terms of similarities and dissimilarities between the isosurfaces of individual modalities, instead of data value combinations. We demonstrate that our approach can be used to robustly extract features in applications such as dual energy computed tomography of parts in industrial manufacturing.
Telestroke Networking Offers Multiple Benefits beyond Thrombolysis

Patients with acute ischemic stroke (AIS) require immediate attention and stroke expertise, which is rarely offered by community hospitals. Telestroke networks were originally established for delivering thrombolysis to inhabitants of underserved regions where stroke expertise was not available 24/7. Rapidly expanding experience addresses the fact that thrombolysis, when given using telestroke consultation, is as safe and effective as when it is given in a stroke center. Telestroke, without a doubt, increases the number of patients receiving thrombolysis, and thus improves patient outcomes, but additionally these networks together with a comprehensive organization of acute stroke care could bring many other benefits which so far are heavily underused in neurology. These benefits include: shortening hospital stay of patients through advanced care, avoiding a large number of unnecessary patient transfers, identifying specific stroke patients who require urgent interventions or surgery (such as subarachnoid hemorrhage, intraventricular hemorrhage, candidates for craniectomy, or basilar artery occlusion), leading to establishment of stroke units and stroke teams in spoke hospitals and overall improvement of stroke care in spoke hospitals, early diagnosis and proper treatment of stroke and nonstroke patients. Further benefits may be: to facilitate staff recruitment to spoke hospitals, to deliver expertise to developing countries, participation of spoke hospitals to acute stroke treatment trials and stroke prevention trials, and environmental effects. The magnitude of these benefits will become more obvious in the near future because this exciting field is progressing fast. The Finnish experience suggests that telestroke is a versatile tool for improving acute stroke care of inhabitants in underserved regions and it should be made more widely available.
Dietary Concentrate Supplementation Increases Milk Production and Reduces Predicted Greenhouse Gas Emissions Intensity in Pasture-based Commercial Dairy Farms.

Controlled studies have extensively documented that concentrate supplements typically increase enteric methane (CH4) emissions and milk yield and reduce emissions per unit of milk produced and dry matter intake. However, there have been no studies conducted to determine the effect of concentrate on predicted greenhouse gas emissions from dairy farms representing the Australian pasture-based farming system. Thus, this study sought to determine how dietary concentrate supplementation affects enteric and manure CH4, and N2O of Australian pasture-based dairy farms. The Australian Dairy Carbon Calculator was used, which incorporates emission factors and methodologies used in the National Greenhouse Gas Inventory as reported to the International Panel on Climate Change. Primary data were collected and analyzed from 120 commercial farms in Australia's major dairy regions. Then the farms were divided into 4 groups based on their dietary concentrate supplementation: ≤ 1 (low; 15 farms), 1-2 (moderate;35 farms), 2-3 (high; 35 farms), and ≥ 3 (very high; 35 farms) ton (t) of concentrate dry matter per cow per year. Sources of greenhouse gas emissions were CO2 from concentrate production, enteric CH4, and manure CH4 and N2O. Total dry matter intake, milk yield, and daily enteric CH4 production (g/day) quadratically increased with concentrate level, whereas greenhouse gas emission intensity of milk production (kg CO2eq/kg fat and protein corrected milk) decreased by 14% for farms supplementing with ≥ 3 tDM/cow per year compared with those supplementing with ≤ 1 tDM/cow per year of dietary concentrate. The emissions of N2O and CH4 from manure increased quadratically and linearly, respectively, with the increasing supplementation of concentrate. Farms supplementing 2-3 tDM/cow per year showed substantial increases in gross income, gross margin, earnings before interest and tax, and net income ($/cow/year) compared with those supplementing of ≤ 1, 1-2, and ≥ 3 tDM/cow per year. In conclusion, increasing dietary concentrate supplementation for dairy cows resulted in increased milk production per cow, reduced greenhouse gas emissions per unit of milk produced, and increased income and profit. However, a comprehensive life cycle assessment study is needed to account for carbon sequestration by other farm components such as pastures and trees, which were not considered in the present study. In addition, the present study was based on modeling and did not gather ground truth information for DMI, digestibility, crude protein, and urinary and fecal N excretion. Therefore, data should be interpreted with caution, and studies gathering such information are encouraged.
Quality of Life and Obstructive Sleep Apnea Symptoms After Pediatric Adenotonsillectomy

BACKGROUND AND OBJECTIVES: Data from a randomized, controlled study of adenotonsillectomy for obstructive sleep apnea syndrome (OSAS) were used to test the hypothesis that children undergoing surgery had greater quality of life (QoL) and symptom improvement than control subjects. The objectives were to compare changes in validated QoL and symptom measurements among children randomized to undergo adenotonsillectomy or watchful waiting; to determine whether race, weight, or baseline OSAS severity influenced changes in QoL and symptoms; and to evaluate associations between changes in QoL or symptoms and OSAS severity. METHODS: Children aged 5 to 9.9 years with OSAS (N = 453) were randomly assigned to undergo adenotonsillectomy or watchful waiting with supportive care. Polysomnography, the Pediatric Quality of Life inventory, the Sleep-Related Breathing Scale of the Pediatric Sleep Questionnaire, the 18-item Obstructive Sleep Apnea QoL instrument, and the modified Epworth Sleepiness Scale were completed at baseline and 7 months. Changes in the QoL and symptom surveys were compared between arms. Effect modification according to race and obesity and associations between changes in polysomnographic measures and QoL or symptoms were examined. RESULTS: Greater improvements in most QoL and symptom severity measurements were observed in children randomized to undergo adenotonsillectomy, including the parent-completed Pediatric Quality of Life inventory (effect size [ES]: 0.37), the 18-item Obstructive Sleep Apnea QoL instrument (ES: –0.93), the modified Epworth Sleepiness Scale score (ES: –0.42), and the Sleep-Related Breathing Scale of the Pediatric Sleep Questionnaire (ES: –1.35). Effect modification was not observed by obesity or baseline severity but was noted for race in some symptom measures. Improvements in OSAS severity explained only a small portion of the observed changes. CONCLUSIONS: Adenotonsillectomy compared with watchful waiting resulted in significantly more improvements in parent-rated generic and OSAS-specific QoL measures and OSAS symptoms.
The Nuclear Gas Dynamics and Star Formation of Markarian 231

We report adaptive optics H- and K-band spectroscopy of the inner few arcseconds of the luminous merger/ultraluminous infrared galaxy (ULIRG)/QSO Mrk 231, at spatial resolutions as small as 0. ″085. For the first time we have been able to resolve the active star-forming region close to the active galactic nucleus (AGN) using stellar absorption features, finding that its luminosity profile is well represented by an exponential function with a disk scale length 0. ″18-0. ″24 (150-200 pc), and implying that the stars exist in a disk rather than a spheroid. The stars in this region are also young (10-100 Myr), and it therefore seems likely that they have formed in situ in the gas disk, which itself resulted from the merger. The value of the stellar velocity dispersion (~100 km s-1 rather than the usual few times 10 km s-1 in large-scale disks) is a result of the large mass surface density of the disk. The stars in this region have a combined mass of at least 1.6 × 109 M☉, and account for 25%-40% of the bolometric luminosity of the entire galaxy. At our spatial resolution the stellar light in the core is diluted by more than a factor of 10 even in the H band by continuum emission from hot dust around the AGN. We have detected the 2.12 μm 1-0 S(1) H2 and 1.64 μm [Fe II] lines out to radii exceeding 0. ″5. The kinematics for the two lines are very similar to each other as well as to the stellar kinematics, and broadly consistent with the nearly face-on rotating disk reported in the literature and based on interferometric CO 1-0 and CO 2-1 measurements of the cold gas. However, they suggest a more complex situation in which the inner 0. ″2-0. ″3 (200 pc) is warped out of its original disk plane. Such a scenario is supported by the projected shape of the nuclear stellar disk, the major axis of which is significantly offset from the nominal direction, and by the pronounced shift on very small scales in the direction of the radio jet axis, which has been reported in the literature.