Miracle-dz/UniFAR-FTUs huggingface dataset:
A Review of Non-Invasive Techniques to Detect and Predict Localised Muscle Fatigue

Muscle fatigue is an established area of research and various types of muscle fatigue have been investigated in order to fully understand the condition. This paper gives an overview of the various non-invasive techniques available for use in automated fatigue detection, such as mechanomyography, electromyography, near-infrared spectroscopy and ultrasound for both isometric and non-isometric contractions. Various signal analysis methods are compared by illustrating their applicability in real-time settings. This paper will be of interest to researchers who wish to select the most appropriate methodology for research on muscle fatigue detection or prediction, or for the development of devices that can be used in, e.g., sports scenarios to improve performance or prevent injury. To date, research on localised muscle fatigue focuses mainly on the clinical side. There is very little research carried out on the implementation of detecting/predicting fatigue using an autonomous system, although recent research on automating the process of localised muscle fatigue detection/prediction shows promising results.
Two Recurrences of Adjacent Spondylodiscitis After Initial Surgical Intervention With Posterior Stabilization, Debridement, and Reconstruction of the Anterior Column in a Patient With Spondylodiscitis: A Case Report

Study Design. Case Report. Summary of Background Data. This report describes a patient who had 2 episodes of destructive spondylodiscitis occurring adjacent to levels at which surgery had previously been carried out due to an initial spondylodiscitis. A review of the literature did not reveal any equivalent cases. A comprehensive description of the management of this unusual course of spondylodiscitis is therefore presented here. Methods. Initially, the patient was suffering from L1-L2 spondylodiscitis caused by previous staphylococcal sepsis. After ineffective conservative antibiotic treatment, surgery was carried out, with posterior instrumentation and fusion at T11-L4 and removal and replacement of the L1 and L2 vertebral bodies. Results. After 2 months, the patient presented with paraparesis due to adjacent spondylodiscitis at T10-T11. The posterior instrumentation was therefore extended up to T9, and removal of the vertebral body of T11 was carried out. After 14 months, the patient was readmitted with pain and increased inflammatory parameters due to spondylodiscitis at T8/T9. Removal of the vertebral bodies was again carried out at T8 and T9, and posterior fusion up to T5 was performed. The patient received antibiotic treatment from 2 months before the first operation up to 3 months after surgery. Conclusion. Newly developing spondylodiscitis adjacent to a level at which a previous spondylodiscitis has been treated surgically is a rare condition, and aggressive treatment is necessary.
Characterization of the C-Terminal Diglycine Motif of SUMO-1/3

A hallmark of small ubiquitin-related modifier (SUMO) is the production of a C-terminal tail containing diglycines (GGs), which are believed to be required for SUMOylation. Whether GGs are required components in SUMOylation remains unanswered experimentally. In this study we found that the SUMO-1/3-AA/-GS/-GN/-GA mutant can form sodium dodecyl sulfate (SDS)-dithiothreitol (DTT)-resistant complexes with cellular proteins, indicating that the GG motif is not strictly required for SUMOylation.
Porous silicon reflectance interference filter used for liquid concentration measurement

The aim of the work described in the paper is to fabricate Bragg type porous silicon reflectance interference filters (PSRIF) with optimum quarter wave layer by pulsed etching and to study its application in liquid concentration measurement filed based on reflectance peak shift with ethanol as sample. Orthogonal method has been adopted to optimize fabrication parameters. Under optimal condition, current applied to layers with high and low index were 3.8 mA /35 mA with anodic duration of 36.0 s/3.0 s, pulse interval of 50 ms and duty cycle of 50, and optimal repetition of quarter wave layer with low and high indexes was 6. In room temperature, the full width at half maximum of light emission peak is 13 nm and position of reflectance peak was 475.6 nm. Thereafter, as-prepaired porous silicon was used to measure liquid concentration. Results show that reflectance peak of PSRIF filled with ethanol shifts to longer direction compared to that of as-prepared samples and the shift is proportional to ethanol concentration. The regularity fits sodium chloride and sucrose as well.
Parsing Extended Constraint Synchronous Grammar in Chinese-Portuguese Machine Translation

This paper presents a design model for parsing an extended version of Constraint Synchronous Grammar (CSG) for Chinese-Portuguese MT, which was initially applied in the reverse way. CSG is a generalization of context free grammars that describes syntactic structures of two languages simultaneously based on the defined constraints. Extensions include the addition of part of speech information in the target syntactic patterns, and the consideration of more information in each constituent’s feature structure.
Speaker Verification via Estimating Total Variability Space Using Probabilistic Partial Least Squares

The i-vector framework is one of the most popular methods in speaker verification, and estimating a total variability space (TVS) is a key part in the i-vector framework. Current estimation methods pay less attention on the discrimination of TVS, but the discrimination is so important that it will influence the improvement of performance. So we focus on the discrimination of TVS to achieve a better performance. In this paper, a discriminative estimating method of TVS based on probabilistic partial least squares (PPLS) is proposed. In this method, the discrimination is improved by using the priori information (labels) of speaker, so both the correlation of intra-class and the discrimination of interclass are fully utilized. Meanwhile, it also introduces a probabilistic view of the partial least squares (PLS) method to overcome the disadvantage of high computational complexity and the inability of channel compensation. And also this proposed method can achieve a better performance than the traditional TVS estimation method as well as the PLS-based method.
LARS Artificial Ligament Versus ABC Purely Polyester Ligament for Anterior Cruciate Ligament Reconstruction

Background: Graft choice for anterior cruciate ligament (ACL) reconstruction is of critical importance. Various grafts have been used so far, with autografts long considered the optimal solution for the treatment of ACL-deficient knees. Limited data are available on the long-term survivorship of synthetic grafts. Purpose: To compare the functional outcome and survivorship of ACL reconstructions performed using the LARS (ligament augmentation and reconstruction system) ligament and the ABC (active biosynthetic composite) purely polyester ligament. Study Design: Case series; Level of evidence, 4. Methods: The results of 72 patients who underwent primary arthroscopic ACL reconstruction with the LARS ligament and 31 cases with an ABC purely polyester ligament were reviewed. The mean follow-up periods for the LARS and ABC groups were 9.5 and 5.1 years, respectively. A survivorship analysis of the 2 synthetic grafts was performed using the Kaplan-Meier method with a log-rank test (Mantel-Cox, 95% CI). Lysholm, Tegner activity, Knee injury and Osteoarthritis Outcome Score (KOOS), and International Knee Documentation Committee (IKDC) scores as well as laxity measurements obtained using a KT-1000 arthrometer were recorded for all intact grafts, and a Mann-Whitney U test was used for comparison reasons. Results: The rupture rates for LARS and ABC grafts were 31% (95% CI, 20%-42%) and 42% (95% CI, 25%-59%), respectively. For intact grafts, the mean Lysholm score was good for both groups (90 for the LARS group and 89 for the ABC group), with the majority of patients returning to their preinjury level of activities, and the mean IKDC score was 90 for the LARS group and 86 for the ABC group. Conclusion: The rupture rates of both LARS and ABC grafts were both high. However, the LARS ligament provided significantly better survivorship compared with the ABC ligament at short- to midterm follow-up (95% CI).
DETC 2006-99612 PARAMETRIC AND TOPOLOGICAL CONTROL IN SHAPE OPTIMIZATION

1 Copyright c © 2006 by ASME ABSTRACT We propose a novel approach to shape optimization that combines and retains the advantages of the earlier optimization techniques. The shapes in the design space are represented implicitly as level sets of a higher-dimensional function that is constructed using B-splines (to allow free-form deformations), and parameterized primitives combined with R-functions (to support desired parametric changes). Our approach to shape design and optimization offers great flexibility because it provides explicit parametric control of geometry and topology within a large space of freeform shapes. The resulting method is also general in that it subsumes most other types of shape optimization as special cases. We describe an implementation of the proposed technique with attractive numerical properties. The effectiveness of the method is demonstrated by several numerical examples.
Mobile and ubiquitous malware

Mobile malware is an increasing threat to the world of handheld devices, which can prove to be costlier than PC viruses in the future. The current method used to combat mobile malware is virus signature matching which is based on the slow process of reverse engineering. This paper studies the growth, spread and generic behaviors of mobile and ubiquitous malware in mobile phones. We extend the works of Bose et al. and Schmidt et al. with an additional feature to reduce the effectiveness of mobile malware propagation. The objective of our work is to investigate the trends and generic behavioral patterns of mobile malware and suggest a generic proof-of-concept model which combines the works of Bose et al. and Schmidt et al. with a new feature to slowdown the spread of known and unknown mobile malware which may share similar behavioral patterns.
Strength of cellulosic fiber/starch acetate composites with variable fiber and plasticizer content

In this experimental study, the performance of injection-molded short flax and hemp fibers in plasticized starch acetate were analyzed in terms of strength. Parameters involved in the analysis are a variable fiber and plasticizer content. The measured strength of the composites varies in the range of 12–51 MPa for flax fibers and 11–42 MPa for hemp fibers, which is significantly higher than the properties of the unreinforced starch acetate matrix. The micro-structural parameters used in modeling of composite strength were obtained from optical observations and indirect measurements. Some of these parameters were qualitatively verified by X-ray microtomography.
Ipilimumab in prostate cancer

Introduction: Immune checkpoint inhibitors, such as ipilimumab, are a new class of immunotherapeutic agents that have shown significant efficacy in melanoma. A number of ongoing clinical trials are investigating the role of ipilimumab in prostate cancer, either alone or in combination with immunomodulating agents such as radiation and chemotherapy, and in combination with cancer vaccines. Areas covered: This article reviews the molecular basis, preclinical and clinical evidence on the safety and efficacy of ipilimumab in prostate cancer. Medical literature search using MEDLINE and online abstracts database of national meetings form the basis of this article. Expert opinion: A number of preliminary clinical studies suggest the potential therapeutic utility of immune checkpoint inhibitors such as ipilimumab in prostate cancer. Pending the results of large-scale studies, the rationale of combining ipilimumab with standard anticancer therapeutics such as radiation, cytotoxic chemotherapy and other immunotherapeutic agents can be of great value in reducing mortality and morbidity in prostate cancer.
An augmented lagrangian method for piano transcription using equal loudness thresholding and lstm-based decoding

A central goal in automatic music transcription is to detect individual note events in music recordings. An important variant is instrument-dependent music transcription where methods can use calibration data for the instruments in use. However, despite the additional information, results rarely exceed an f-measure of 80%. As a potential explanation, the transcription problem can be shown to be badly conditioned and thus relies on appropriate regularization. A recently proposed method employs a mixture of simple, convex regularizers (to stabilize the parameter estimation process) and more complex terms (to encourage more meaningful structure). In this paper, we present two extensions to this method. First, we integrate a computational loudness model to better differentiate real from spurious note detections. Second, we employ (Bidirectional) Long Short Term Memory networks to re-weight the likelihood of detected note constellations. Despite their simplicity, our two extensions lead to a drop of about 35% in note error rate compared to the state-of-the-art.
Improved arithmetic coding for Time-Warped MDCT based audio coding

The Time-Warped Modified Discrete Cosine Transform (TW-MDCT) improves the energy compaction for harmonic signals with varying fundamental frequency compared to the plain MDCT. Adaptive context based entropy coding has the potential to provide higher gain over memoryless entropy coding. But in combination with the TW-MDCT, the context based adaptive coding may lead to suboptimal coding. This paper presents an algorithm for improving the context for the TW-MDCT. This is mainly achieved by exploiting already available information on the frequency variation needed by the TW-MDCT. This results in an improved entropy coding.
Towards faster InP photonic crystal all-optical-gates

We demonstrated a two-fold acceleration of the fast time constant characterising the recovery of a P-doped Indium-Phosphide Photonic Crystal all-optical gate. Time-resolved spectral analysis is compared with a three-dimensional drift-diffusion model for the carrier dynamics, demonstrating the transition from the ambipolar to the faster minority carrier dominated diffusion regime. This open the perspective for faster yet efficient nanophotonic all-optical gates.
Experiment Study of Thermoforming of Plain Woven Composite (Carbon/Thermoplastics)

By combining carbon woven fabric with thermoplastics grains, a thermo-stamping process is proposed for forming parts with complex double curvatures in one step, to implement the affordable application of fiber reinforced composites in high volume merchandises such as automotive industry. In the proposed thermo-stamping process, laminated carbon woven fabrics with thermoplastic grains are heated, and then transferred rapidly to a preheated mould for thermo-stamping, and cooled down to form the carbon fiber reinforced composite part. Various thermoplastics such as PP, PA6 and ABS are used as matrix material in the composite part. Experimental results including shear angle distribution in the fabric, deformed boundary profile of fabric with different original fiber orientation and forming defects are presented. It is demonstrated that high quality parts can be obtained with the proposed forming process, and defects are controllable. By using the proposed process and laminated structures, it is feasible to implement the high-volume and low-cost manufacturing of fiber reinforced composite parts.
Inactivation of delayed outward current in molluscan neurone somata.

1. Inactivation of delayed outward current was studied by voltage clamp of isolated neurone somata of the molluscs Archidoris and Anisodoris. During prolonged voltage clamp steps in normal artificial sea water delayed outward current rises to a peak and then declines to a non‐zero steady‐state. During repetitive clamp pulses at repetition rates slower than 2/sec, the amplitude of peak outward current in the second pulse is commonly less than the amplitude at the end of the preceding pulse, giving the impression of continued inactivation during the repolarized interval. We have termed this property cumulative inactivation. 2. Two components of delayed outward current were separated using tetraethyl ammonium ions (TEA) and cobalt ions (Co). External TEA blocks 90% of a voltage and time dependent outward current termed K current (IK). External Co blocks 85% of a Ca activated delayed outward current termed Ca current (ICa does not inactivate during prolonged or repetitive voltage clamp pulses. IK, however, inactivates during prolonged voltage clamp steps and shows cumulative inactivation during repetitive voltage clamp pulses. 3. Inactivation of IK is voltage and time dependent and does not require influx of Ca ions. 4. As measured by a prepulse method, the onset of inactivation is characterized by a two time constant process. Fast inactivation occurs with a time course comparable to the rate of rise of outward current and can account for 90% of total inactivation. 5. Recovery from inactivation is slow with a time constant approximately an order of magnitude slower than the onset of inactivation. 6. The current‐voltage (I‐V) curve for peak IK can be N‐shaped, with a region of negative slope resistance in the range of +30 to +80 mV. The I‐V curve for steady‐state IK, however, shows little or no tendency to form a local maximum. 7. The pattern of delayed outward current varies considerably between cells. A major contributing factor to this variability appears to be the relative contributions of ICa and IK to delayed outward current.
Platelets and acute cerebral infarction

Stroke is worldwide a leading cause of death and disability. Its etiology is regarded as heterogeneous. Platelets are implicated in its pathophysiology, but our understanding of their specific role is incomplete. Only sparse and conflicting information exists about platelet reactivity and activity in acute stroke. Some scientists take the view that platelets activate in conjunction with acute cerebral infarctions. Others put forward evidence corroborating the contrary notion. Increased soluble P-selectin as a sign of platelet and/or endothelial activity seems to be a feature of the disease. The latter point of view is opposed by other researchers. Due to these conflicting opinions, this study is devoted to platelet characteristics in acute cerebral infarctions. We studied subjects (n = 72; age 74 ± 10(SD) years; 31 females) having acute stroke. As controls served atrial fibrillation (AF) patients (n = 58; age 69 ± 7(SD) years; 12 females) subject to electrical cardioversion, a flow cytometer was put to use for measuring platelet reactivity and activity. After agonist provocation, both platelet bound P-selectin and fibrinogen were employed as estimates of platelet reactivity. Dilutions of a thrombin-receptor-activating peptide (TRAP-6) (74 and 57 µmol/l) (P-selectin and fibrinogen) and ADP (8.5 and 1.7 µmol/l) (fibrinogen only) were put to use as platelet agonists. Membrane-bound P-selectin without agonist stimulation served as a measure of in vivo platelet activation. Soluble P-selectin, as determined from a commercial ELISA, was used to assess platelet and/or endothelial activity. In acute stroke neither platelet-bound P-selectin nor fibrinogen after stimulation, i.e. reactivity, differed from AF controls. In contrast, lower platelet activity as judged from surface attached and circulating P-selectin without agonist stimulation proved to be a feature of cerebral infarctions. The p-values were p < 0.001 and p < 0.01, respectively. It is concluded that acute stroke is not associated with platelet reactivity platelets circulate less activated during the disease. It is evident that the mechanisms reflecting platelet reactivity and activity being investigated in this study play minor roles in stroke pathophysiology. New powerful platelet inhibitory drugs are currently introduced. To avoid major bleeding studies on platelet, behavior in acute stroke are necessary before including these medications in stroke treatment protocols.
A dual-core 64-bit ultraSPARC microprocessor for dense server applications

A dual-core 64-bit microprocessor optimized for compute-dense systems such as rack-mount and blade servers for network computing was developed. The chip consists of two UltraSPARC II cores, each with its own 512 kB L2 cache, a DDR-1 memory controller, and symmetric multiprocessor bus (JBus) controllers. The 206-mm/sup 2/ die is fabricated in 0.13-/spl mu/m CMOS technology with seven layers of Cu and a low-k dielectric. The chip offers a highly efficient performance-per-watt ratio with a typical power dissipation of 23 W at 1.3 V and 1.2 GHz. A short design cycle was achieved by leveraging existing designs wherever possible and developing effective design methodologies and flows. Significant design challenges faced by this project are described. These include deep-submicron design issues, such as negative bias temperature instability (NBTI), leakage, coupling noise, intra-die process variation, and electromigration (EM). A second important design challenge was implementing a high-performance L2 cache subsystem with a short four-cycle core-to-L2 latency including ECC.
Perception-based high dynamic range video compression with optimal bit-depth transformation

High Dynamic Range (HDR) technology is able to offer high levels of immersion with a dynamic range comparable to the Human Visual System (HVS). A primary drawback of HDR is that its memory and bandwidth requirements are significantly higher than for conventional video. The challenge is thus to develop means for efficiently compressing the video to a manageable bitrate without compromising perceptual quality. In this paper, we propose an HDR compression method based on an optimized bit-depth transformation, and HVS model based wavelet transform denoising. Experimental results indicate that the proposed method outperforms previous approaches and operates in accordance with characteristics of the HVS, tested objectively using a Visible Difference Predictor (VDP).
Experimental Results and Algorithm Analysis of DEM Generation Using Bistatic SAR Interferometry With Stationary Receiver

This paper presents the theory, algorithm, and results of a new bistatic interferometry synthetic aperture radar (InSAR) method. It employs the data acquired in an innovative bistatic configuration, which uses the orbital sensors as transmitters of opportunity and the stationary receivers on the ground, to generate a digital elevation model (DEM). In the bistatic spaceborne/stationary InSAR configuration, the interferometric phase only depends on the target-receiver range, which could not be obtained directly from the measured bistatic range. Therefore, the conventional transforming relationship between the interferometric phase and the topographic height is no longer practical. In order to solve the problem, we introduce a new conversion relationship between the interferometric phase and the topographic height, which is derived by the model of the ellipsoidal projection in the bistatic configuration. Meanwhile, the error analysis of the new conversion is carried out through a simulation. Both the simulated and measured data are used to test and verify the feasibility of the new bistatic InSAR method. In the spaceborne/stationary InSAR experiment, YaoGan-3 (an L-band spaceborne SAR system launched by China) was selected as the transmitter and two stationary receivers were mounted on the top of a tall building. The generated DEM of high quality shows that the presented method performs very well in the bistatic InSAR data process.