Miracle-dz/UniFAR-FTUs huggingface dataset:
Percutaneous transluminal in vivo gene transfer by recombinant adenovirus in normal porcine coronary arteries, atherosclerotic arteries, and two models of coronary restenosis.

BACKGROUND Gene therapy has been proposed as a possible solution to the problem of restenosis after coronary angioplasty. The current study was undertaken to assess conventional methods of gene transfer and to develop percutaneous techniques for introducing genes directly into the coronary arteries of large mammals. Since the anticipated targets of gene therapy against restenosis include atherosclerotic and previously instrumented arteries, we also evaluated gene transfer in atherosclerotic coronary arteries and in two porcine models of restenosis: one using intracoronary stents and a second using balloon overstretch angioplasty. METHODS AND RESULTS The conventional method of using perforated balloon catheters to deliver Lipofectin-DNA complexes directly into the coronary arteries of intact animals was applied to 18 porcine coronary arteries including normal arteries, hypercholesterolemic arteries, and those simulating restenosis. The results of this study were consistent with previously published results indicating that only low levels of luciferase gene expression could be obtained by Lipofectin-mediated gene transfer. We therefore undertook a second, parallel study to evaluate percutaneous transluminal in vivo gene transfer using a replication-deficient adenoviral vector. A comparison of the two studies revealed that the mean level of reporter gene expression in the cohort undergoing adenoviral infection was 100-fold higher than in the cohort undergoing Lipofection. Analysis of luciferase activity over time in normal arteries revealed that recombinant gene expression was half-maximal after 1 day, peaked within 1 week, was still half-maximal at 2 weeks, and declined to low levels by 4 weeks. Histochemical analysis of coronary arteries treated with a second adenovirus expressing a nuclear-localized beta-galactosidase gene demonstrated gene transfer to a limited number of cells in the media and adventitia. Immunohistochemical analysis of Ad5-infused arteries using a monoclonal antibody directed against CD44 identified a periadventitial infiltrate composed of leukocytes. CONCLUSIONS The recombinant adenoviral vectors proved to be far more effective than Lipofectin at delivering foreign genes directly into the coronary arteries of living mammals. Furthermore, the influences of hypercholesterolemia and arterial injury appeared to have little effect on the levels of gene expression obtained using either method. The results demonstrate that low-level recombinant gene expression, the major obstacle impeding gene therapy for the prevention of restenosis, can potentially be overcome by using adenoviral vectors to mediate coronary gene transfer in vivo. The duration of gene expression provided by these vectors and their effective deployment in atherosclerotic, balloon-overstretched, and stented coronary arteries suggest that recombinant adenovirus may have potential for evaluating gene therapy in the clinically informative porcine models of coronary restenosis.
Modification features of the measurement equation for vortex sonic flowmeters

Vortex sonic flowmeters are widely used in the area of housing and public utilities due to their insensitivity to the quality of the measured fluid. Nevertheless, vortex shedding is unstable at low flow rates, which results in an increase of flow measurement errors within this range. This article describes the model of measurement equation for vortex sonic flowmeters based on experimental research of two types of flowmeters with 32 and 50 mm flow tube diameters. The adequacy of the obtained measurement equation model is confirmed based on three types of flowmeters (including the flow tube diameter of 25 mm) and other test modes. The resulting refined model of the measurement equation enables reducing the measurement error from 3 % (rated value) to 0.5 % at low flow rates.
More than the sum of its parts : compact preference representation over combinatorial domains

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Divisible operators in von Neumann algebras

Relativizing an idea from multiplicity theory, we say that an element of a von Neumann algebra M is n-divisible if it commutes with a type In subfactor. We decide the density of the n-divisible operators, for various n, M, and operator topologies. The most sensitive case is σ-strong density in II1 factors, which is closely related to the McDuff property. We also make use of Voiculescu’s noncommutative Weyl–von Neumann theorem to obtain several descriptions of the norm closure of the n-divisible operators in B( ). Here are two consequences: (1) in contrast to the larger class of reducible operators, the divisible operators are nowhere dense; (2) if an operator is a norm limit of divisible operators, it is actually a norm limit of unitary conjugates of a single divisible operator. The following application is new even for B( ): if an element of a von Neumann algebra belongs to the norm closure of the א0-divisible operators, then the weak* closure of its unitary orbit is convex.
Evaluation of Hospital Information Systems in Selected Hospitals of Iran

Background: Due to the information systems` objectives, and to avoid duplication and to help improve care quality and reduce cost, it is necessary to conduct continuous evaluation to determine how to achieve these goals. This study was performed using evaluation indices of hospital Information systems in selected hospitals of Iran in 2012. In this article organizational and server components of hospital information systems in selected hospitals are being assessed. Methods: This research is a descriptive cross – sectional study. The study population consisted of the information system of Shohaday Tajrish, Khatamolanbiya, Imam Khomeini and Milad Hospital. Data collecting tools were checklist of hospital information system Evaluation Index, which completed with direct observation and interviews with users. Data analyzed by statistics software SPSS, and presented as statistical tables and graphs. Results: In the studied hospitals, although the most of the organizational components subgroups and hospital information system server components has been set up and used but pharmacy information system, decision support systems, communication services and telemedicine services hadn`t been set up fully in the hospitals. Conclusion: Currently most subtypes of organizational components and hospital information system server components were fully in the designed software and considering all fields in 5 hospitals.
Kinship Care: an Afrocentric perspective

This thesis explores the experiences and meanings that are attributed to kinship care by caregivers, young people of African descent, and social workers. It examined the meanings each group attached to kinship care and the risk and resilience they saw within it. The research was framed within the culturally distinctive theoretical framework of the Afrocentric paradigm which encapsulates cultural values. A qualitative approach was adopted for data collection, using interviews, and aspects of Grounded Theory for data analysis. The findings show that kinship care is a survival strategy that has historical significance for people of African descent, because it is linked to a tradition of help and a broad base of support. The study found that while local authorities were formally placing children with their relatives, there was a distinct lack of policy development to support kinship care as a welfare service. The absence of clearly identified support structures, tools for assessment, training and monitoring increased the risk factors for children who were placed in kinship care. Resilience was transferred through the Afrocentric cultural values, a key factor that led to family preservation and placement stability. The study concluded that there is an urgent need to reframe policy and practice.
Relationship Between Organizational Rewards Satisfactions and Work Performance

While performing their duties in an organization, an employee performance can be viewed through the provision of rewards, benefits, pay levels and pay for their administration. It was called work performance. The inquiry based on part-time students to master, in relation to the satisfaction of reward, it has 4 items, which pay level, benefit satisfaction has roughly three main items, namely training, health and rights, then there also raise satisfaction and salary administration. It is because; this research title is aimed to determine the Relationship between reward satisfaction and work performance. The objective of this study are; to examine relationship between pay level and work performance, to examine relationship between benefits and work performance, to examine relationship between raise satisfaction and work performance and to examine relationship between salary administrative and work performance. A total of 138 questionnaires were distributed to 138 part time postgraduate students at UUM Campus KL and UUM Campus Sintok, Kedah by e-mail and only 116 questionnaires were returned for analysis. Data were analyzed using both descriptive and inferential statistical analysis to interpret data. Research findings revealed there was work performance existing among the respondents. Significant values for each element in independent variable which the item of reward such as pay level, benefit, raise and structure. The higher significant value of independent variables are work performance and item benefits, 0.152 > 0.05. It does can refer from the Heneman and Schwab (1985) which are studied about the pay level, benefit, raise satisfaction and salary administrative. For the individual’s pay level also play an important role in individual work performance and more substantial evidence which are reference for various pay and benefit combinations that are as a function of personal characteristic of employees. There are including with the four dimensions of reward satisfaction; level, benefit, raise and structure (Heneman & Schwab, 1985).
Effect of the novel ionophore tetronasin (ICI 139603) on ruminal microorganisms

The antimicrobial activity of the novel ionophore tetronasin (formerly ICI 139603) was compared with that of monensin for the growth of ruminal bacteria, protozoa, and an anaerobic fungus. The potency of tetronasin toward most bacteria and the fungus was an order of magnitude or more greater than that of monensin. Lactobacillus casei was 55 times more sensitive to tetronasin than to monensin, indicating a potential role for tetronasin in reversing lactic acidosis. Bacteria with a gram-positive ultrastructure were generally sensitive to the ionophores and unable to adapt to grow in their presence. The exception was the cellulolytic Ruminococcus flavefaciens, which adapted during successive cultivation on media with increasing ionophore concentrations to grow at 100-fold higher concentrations of tetronasin than were initially lethal to the organism. Gram-negative bacteria were more resistant and generally able to adapt to grow in the presence of both ionophores. An in vivo trial with cattle and in vitro growth experiments indicated that the effect of tetronasin on ciliate protozoa was minor. In vitro experiments measuring hydrogen production by Neocallimastix frontalis suggested that this fungus would be unable to survive in ruminants receiving tetronasin.
Iron K-features in the hard X-ray XMM—Newton spectrum of NGC 4151

ABSTRACT Recent XMM-Newton observations have measured the hard (2.5-12 keV) X-rayspectrum of the well-known Seyfert galaxy NGC 4151 with a signal-to-noise unprece-dented for this source. We ﬁnd that a spectral model, developed to ﬁt previous Bep-poSAX and ASCA observations of NGC 4151, provides an excellent description ofthe XMM-Newton EPIC data. The results support the view that it is the level ofthe continuum that is the main driver of the complex spectral variability exhibitedby NGC 4151. We focus on the iron K features in the NGC 4151 spectrum. Thereis no requirement for a relativistically broadened iron Kα line, in contrast to severalearlier studies. The iron Kα line proﬁle is well modelled by a narrow Gaussian, theintensity of which varies by ∼25% on timescales of about a year. There is also a strongsuggestion that the cold media present in the active nucleus of NGC 4151 have an ironabundance that is at least twice the solar value.Key words: galaxies: active - galaxies: Seyfert - X-rays: galaxies - galaxies: NGC4151. Galaxies
Chemokine Receptor and Ligand Upregulation in the Diaphragm during Endotoxemia and Pseudomonas Lung Infection

Sepsis-induced diaphragmatic inflammation has been associated with respiratory failure, but the role of chemokines in this process has not been evaluated. Here we sought to study the local expression and molecular regulation of the chemokines, regulated upon activation normal T cell expressed and secreted (RANTES) and macrophage inflammatory protein (MIP)-1α, in the murine diaphragm during sepsis. Constitutive expression levels of RANTES and MIP-1α, as well as their receptors, CCR1 and CCR5, were significantly higher in diaphragm than limb muscle. Sepsis was induced by acute lipopolysaccharide (LPS) delivery or subacutely by intratracheal administration of live Pseudomonas aeruginosa bacteria. Both sepsis models triggered a marked upregulation of RANTES and MIP-1α in the diaphragm. In vitro, stimulation of diaphragmatic muscle cells with LPS also led to RANTES upregulation. Inhibition of the NF-kB pathway using pharmacologic or dominant negative genetic approaches blocked the LPS-induced RANTES upregulation, while free radical scavengers had no effect. We conclude that sepsis leads to greatly increased expression of RANTES, MIP-1α and their cognate receptors in the diaphragm. Manipulation of the NF-kB pathway and other regulators of chemokine expression in the diaphragm could represent a novel method for mitigating the skeletal muscle inflammatory response associated with sepsis-induced diaphragmatic dysfunction.
Bone morphogenetic protein is required for fibroblast growth factor 2-dependent later-stage osteoblastic differentiation in cranial suture cells.

BACKGROUND Understanding the pathophysiological process of calvarial bones development is important for the treatments on relative diseases such as craniosynostosis. While, the role of fibroblast growth factor (FGF) and bone morphogenetic protein (BMP) and how they interacted in osteoblast differentiation remain unclear. METHODS we digested bone fragments around the coronal and sagittal sutures from newborn rats to harvest suture cells. Markers expression at different osteoblast differentiation stage was analyzed by increasing FGF2 concentration and BMP2 blocking in these cells. RESULTS BMP2 expression could be stimulated by FGF2 in a dose and time dependent manner. FGF2 stimulation may decrease early marker of osteoblast differentiation (collagen type-1, COL-1) and increase the expression of continuously-expressed or late markers (alkaline phosphatase, ALP; osteocalcin, OC and bone sialoprotein, BSP) to accelerate mineralization. Inhibition of BMP2 signaling by Noggin weakens the effect of FGF2 on induction of later-stage osteoblastic differentiation of cranial suture cells. CONCLUSION Our data suggest that BMP2 signaling is required for FGF2-dependent induction of later-stage of cranial suture cell osteoblastic differentiation.
A parallel approach toward correlation measurement for gene pairs with time-lagging expression behaviours

Time-lagging in expression occurs when a gene's expression triggers a delayed expression in its co-regulated or anti-co-regulated peers. Arbitrary time-lagging also might appear due to experiment or measurement error. Traditional methods will either under-estimate or completely miss such correlation, which is not unusual and plays important roles. Since the traditional similarity measurement cannot capture the true relationship, a simple time-lagging captured algorithm integrated with some existing time-lagging and similarity measurement techniques is proposed with parallel implementation. Improvements such as isolation of experimental conditions and weighted averages are used to achieve better accuracy and give user flexibility to differentiate different experiments.
Evaluation of Cheating Detection Methods in Academic Writings

Purpose – This paper aims to focus on plagiarism and the consequences of anti‐plagiarism services such as Turnitin.com, iThenticate, and PlagiarismDetect.com in detecting the most recent cheatings in academic and other writings.Design/methodology/approach – The most important approach is plagiarism prevention and finding proper solutions for detecting more complex kinds of plagiarism through natural language processing and artificial intelligence self‐learning techniques.Findings – The research shows that most of the anti‐plagiarism services can be cracked through different methods and artificial intelligence techniques can help to improve the performance of the detection procedure.Research limitations/implications – Accessing entire data and plagiarism algorithms is not possible completely, so comparing is just based on the outputs from detection services. They may produce different results on the same inputs.Practical implications – Academic papers and web pages are increasing over time, and it is very .
Learning to Teach Adults: Principles of Adult Education in the Writings of EllenWhite

This paper examines the writingsofEllen White for the presence and application of several key adult education principles asidentifiedby Malcolm Knowles. The practicalapplication of these principles is thenexaminedinthe teachingofcollegeEnglish as a secondlanguage and compulsorygeneraleducation Bible classes. Theseprinciples can also be applied toother areas, and their implementationwill make for better teachers who will integrate their faith intheir contentareas, andmay provide clues for the improvement ofstrategies for communicatingthe gospel to adults.
Etablering av en gruppe for psykiatrisk epidemiologisk forskning i Bergen

For a oke bredden av det psykiatriske forskningsmiljoet i Bergen, ble det i 1999 startet en arbeidsgruppefor psykiatrisk epidemiologi. Arbeidsgruppen har 15 medlemmer som alle har pagaende prosjekter, og somhar mottes regelmessig. Materialet for gruppens arbeid har vaert Helseundersokelsene i Nord-Trondelag(HUNT-II) og i Hordaland (HUSK). Utfallsvariablene i vare prosjekter har vaert angst og depresjon maltved selvutfyllingtesten Hospital angst og depresjonsskala (HADS). I Bergensgruppen er angst og depresjonundersokt i forhold til kodimensjonalitetet, fysisk aktivitet, body mass index/hip-waist ratio, global helse,gastrointestinale symptomer, menopause, p-piller, svangerskap og fodsler, sovnplager, royking, migrene,whiplash, epilepsi, folat-metabolisme, kreft, yrke og helsetjenester. Det ser ut til at vi har dannet grunnlagetfor en stabil og produktiv gruppe som sammen med andre grupper kan bidra til et aktivt miljo for psykia-trisk epidemiologi ved Universitetet i Bergen.Dahl AA, Bjelland I, Moe TJ, Mykletun A, Roness A.
European Union Broadcasting and Telecoms

After placing the development of EU broadcasting and telecommunications policy into its historical context, the article argues that the EU, having traditionally found it difficult to develop a regulatory regime concerning content and culture, has primarily utilized telecommunications regulation in regard to broadcasting. This framework is a necessary but insufficient base for the regulation of convergent technologies.
The Gene Controlling the Quantitative Trait Locus EPITHIOSPECIFIER MODIFIER1 Alters Glucosinolate Hydrolysis and Insect Resistance in Arabidopsis[W]

Glucosinolates are sulfur-rich plant secondary metabolites whose breakdown products have a wide range of biological activities in plant–herbivore and plant–pathogen interactions and anticarcinogenic properties. In Arabidopsis thaliana, hydrolysis by the enzyme, myrosinase, produces bioactive nitriles, epithionitriles, or isothiocyanates depending upon the plant's genotype and the glucosinolate's structure. A major determinant of this structural specificity is the epithiospecifier locus (ESP), whose protein causes the formation of epithionitriles and nitriles. A quantitative trait locus (QTL) on chromosome 3 epistatically affects nitrile formation in combination with ESP; this QTL has been termed EPITHIOSPECIFIER MODIFIER1 (ESM1). We identified a myrosinase-associated protein as the ESM1 QTL in Arabidopsis using map-based cloning with recombinant inbred lines, natural variation transcriptomic analysis, and metabolic profiling. In planta and in vitro analyses with natural ESM1 alleles, ESM1 knockouts, and overexpression lines show that ESM1 represses nitrile formation and favors isothiocyanate production. The glucosinolate hydrolysis profile change influenced by ESM1 is associated with the ability to deter herbivory by Trichoplusia ni. This gene could provide unique approaches toward improving human nutrition.
The salience of overweight in personality characterization.

It is argued that the stigma attached to overweight or obesity often causes overweight to operate as a "master status. " College students (N = 223) were asked to write stories about male and female stimulus characters who varied only in body image. It was hypothesized that subjects writing about overweight stimulus characters would be more likely than those writing about normal weight characters to (a) write sad or negative stories, (b) create unpleasant characters, and (c) describe their characters with more negative personality characteristics on a semantic differential personality scale. Support was found for part (a) and (b) of the hypothesis but not part (c). The relationships were stronger when the stimulus was a picture than when it was a descriptive paragraph and when the stimulus character was female rather than male. There was indication that female subjects were more likely to associate an overweight body image with an unpleasant personality than were male subjects.
A sparse EM algorithm for blind and semi-blind identification of doubly selective OFDM channels

In recent years many sparse estimation methods, also known as compressed sensing, have been developed for channel identification problems in digital communications. However, all these methods presume the transmitted sequence of symbols to be known at the receiver, i.e. in form of a training sequence. We consider blind identification of the channel based on maximum likelihood (ML) estimation via the EM algorithm incorporating a sparsity constraint in the maximization step. We apply this algorithm to an OFDM transmission over a doubly-selective multipath channel with strong Doppler and delay spread.