Miracle-dz/UniFAR-FTUs huggingface dataset:
Mixed-methods exploration of the knowledge of young adults about blood donation processes; a one-center cross-sectional study in a tertiary institution

Ghana is a majority youthful population, but is only able to meet 60% of its annual blood donation requirements. Although tertiary students in Ghana may serve as important blood donor resource by virtue of their higher educational attainment, data about their blood donation processes-specific knowledge are scarce. This study therefore explored the perspectives, and experiences of young adults regarding blood donation processes. This exploratory study employed mixed-methods approach (semi-structured questionnaire and focus group discussion, [FGD]). Data collection was sequential; the questionnaire distribution was completed before FGD commenced; themes that emerged from the questionnaire responses guided FGDs. Convenience sampling technique was used to recruit 382 young adults (15–49 years). All statistical analyses were undertaken using the two-tail assumptions; p<0.05 was considered statistically significant. Majority (79.3%) of the participants were in their twenties, with only 1.3% being 40–49 years old. Although two-thirds of participants expressed willingness to donate blood, less than a-third (31.7%; 127/382) had previously donated blood. Overall, less than one-third of participants could correctly identify the minimum weight (26.4%), or the inter-donation interval (14.7%); 37.4% and 58.1% could respectively indicate the required donor age or ≥3 infectious agents screened for prior to blood collection. Among previous donors, 37.2%, 28.1% and 43.0% could identify the required weight, acceptable inter-donation period, and donor age respectively. Two-thirds and a-third of participants preferred voluntary unrelated, and paid donations respectively. Whereas 42.4% of participants indicated intrinsic health benefits of blood donation, 17.0% suggested that blood donation was associated with disease risks. Both previous donors and non-donor groups considered lack of education, fear of post-donation health issues and lack of privacy at blood collection centers as main hindrances to donor recruitment. Targeted intentional blood donation-specific educational campaigns are warranted to address the blood donation processes knowledge gap among the study population.
Fat tails and the need to disclose distribution parameters of qEEG databases

Neurometry (a.k.a. quantitative EEG or qEEG) is a popular method to assess clinically relevant abnormalities in the electroencephalogram. Neurometry is based on norm values for the distribution of specific EEG parameters and believed to show good psychometric properties such as test-retest reliability. Many psychometric properties only hold under the Gaussian distribution and become problematic when distributions are fat-tailed. EEG signals are typically fat-tailed and do not show fast convergence to a Gaussian distribution. To circumvent this property of EEG, log-transformations have frequently, but not always been employed. In Monte Carlo simulations, we investigated the impact of fat-tails (i.e. deviations from Gaussian) on the cut-off criteria and changeability of what in neurometry is termed “abnormal EEG”. Even slight deviations from the Gaussian distribution as measured by skewness and kurtosis lead to large inflation in the number of false positive qEEG findings. The more stringent the cutoff value adopted, the larger the inflation. Moreover, “abnormal EEG” seems to recover spontaneously at rates not compatible with the alleged test-retest reliability of qEEG. Alternative methods should be employed to determine cut-off values for diagnostics purposes, since a large number of false positive results emerge even when slight deviations from the Gaussian distribution are present. We argue that distribution properties of qEEG databases should be disclosed in much more detail by commercial providers to avoid questionable research practices and promote diagnostic transparency. We provide recommendations for the improvement of psychometric properties of existing qEEG databases.
Does blockchain technology matter for supply chain resilience in dynamic environments? The role of supply chain integration

This study aims to empirically investigate the effect of blockchain technology (BCT) adoption on supply chain resilience (SCR), with the mediating role of supply chain integration (SCI) and the crucial effect of environmental dynamism (ED) as a moderator. Based on data collected from firms operating in the automotive industry in India, the proposed model was tested using Partial Least Squares Structural Equations Modelling (PLS-SEM) via SmartPLS software. The empirical results showed a positive effect of BCT on SCI, which in turn affects SCR. Importantly, SCI acts as a full mediator in the BCT-SCR relationship, which is moderated by ED, that is, the effect of BCT on SCR via SCI is strong when ED is high. This study offers the groundwork for operationalizing BCT in a supply chain context. It also contributes to SCR research by investigating how SCI mediates the effect of BCT on SCR. In addition, this study found a moderating effect of ED on the relationship between BCT and SCI. These results provide insights to auto manufacturers on ways to enhance SCR and ensure safe supply chain operations.
Modeling discharge and sediment concentrations after landscape interventions in a humid monsoon climate: The Anjeni watershed in the highlands of Ethiopia

Increasing population and intensification of agriculture increase erosion rates and often result in severe land degradation and sedimentation of reservoirs. Finding effective management practices to counteract the increasing sediment load is becoming increasingly urgent especially in the Ethiopian highlands where the construction of the hydroelectric Grand Renaissance Dam on the Blue Nile is underway. In this paper, we examine the results of 9 years of a watershed experiment in which discharge and sediment losses were observed in the 113 ha Anjeni watershed of the Blue Nile Basin. The study period encompasses conditions before, during, and after the installation of graded Fanya‐Juu (“throw uphill” bunds) soil and water conservation practices (SWCP), which had the ultimate goal of creating terraces. We use a saturation‐excess runoff model named the parameter‐efficient distributed model as a mathematical construct to relate rainfall with discharge and sediment losses at the outlet. The parameter‐efficient distributed model is based on landscape units in which the excess rainfall becomes direct runoff or infiltrates based on topographic position or hardpan characteristics. Deviations in this rainfall–discharge–sediment loss relationship are ascribed to the changes in infiltration characteristics caused by SWCPs on the hillslopes. With this technique, we found that in the Anjeni basin, the Fanya‐Juu SWCPs are only effective in increasing the infiltration and thereby reducing the direct runoff and sediment concentrations in the first 5 years. At the end of the 9‐year observation period, the direct runoff and sediment concentrations were barely reduced compared to the levels before SWCP were installed. In addition, we found that the model structure based on landscape units was able to represent the varying runoff and erosion processes during the 9 years well by varying mainly the portion of degraded land (and thereby representing the effectiveness of the Fanya‐Juu to reduce runoff by increasing infiltration).
Integrative emotion regulation relates to sympathy and support for outgroups—Independent of situational outgroup behaviour

Intergroup emotions powerfully shape intergroup relations. Anger and fear fuel, while hope and sympathy reduce intergroup strife. This implies that emotion regulation may play an important role in improving intergroup relations. Broadening the scope of prior research, we herein investigate the potential benefits of integrative emotion regulation for improving intergroup relations. Integrative emotion regulation involves actively paying attention to emotions to determine which information they provide. Interindividual differences in the use of integrative emotion regulation correlate with sympathy and supportiveness towards outgroups, but why this is the case is unclear. We tested two possible explanations: a person effect (i.e., interindividual differences in integrative emotion regulation shape respondents’ general outlook on outgroups) and a person-situation interaction effect (i.e., integrative emotion regulation reduces the impact of situational factors that would typically dampen sympathy, thereby shaping situation-specific responses to outgroups). In four experiments (total N = 984), we manipulated outgroup behaviour and measured interindividual differences in integrative emotion regulation. We found no interaction between integrative emotion regulation and outgroup behaviour in predicting outgroup-directed sympathy and supportiveness. Instead, integrative emotion regulation consistently correlated positively with supportiveness, mediated by sympathy. These findings suggest that those high in integrative emotion regulation have a more positive, general outlook on outgroups than those low in integrative emotion regulation, but being high in integrative emotion does not alter situational responses.
Hypoxia inducible factor prolyl hydroxylase inhibitors: what a meta-analysis could tell us

ABSTRACT Meta-analyses offer an estimate of the overall effect size and help address the inconsistency in findings across studies. The risk is the overemphasis on statistical significance while underrepresenting or misinterpreting clinical significance. There's also a lack of standardized methods for quantifying and reporting clinical significance and these measures are often missing or inconsistently reported in many meta-analyses, making it difficult for readers to determine the clinical relevance of the findings. A major merit of Minutolo's meta-analysis is to formally evaluate efficacy and safety of Hypoxia Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHI) as class and as single agents in comparison with ESA, by selecting from only phase-3 randomised clinical trials (RCTs) that compared HIF-PHIs with erythropoiesis-stimulating agents (ESAs) in dialysis and non-dialysis patients. From a clinical perspective, the primary evaluation in this meta-analysis should have been the percentage of patients able to reach and maintain the target haemoglobin (Hb) levels throughout the trials but only a few RCTs selected this primary end point. Any claimed superiority of one drug over another should consider the selected doses. The amount of iron administered to patients, their iron stores and level of inflammation are important confounding factors that affect the reliability of any comparison.
MITOGENOME REPORT The complete mitochondrial genome of the tropical sea urchin Tripneustes gratilla (Linnaeus, 1758) with two spine colors

The complete mitochondrial genomes of two spine-color individuals, red and white, of the tropical sea urchin species Tripneustes gratilla (Linnaeus, 1758) were sequenced on Illumina system platform. The red-spined species had a genome size of 15,774bp, while the white-spined species had a genome size of 15,723bp. Both genomes contained 13 protein-coding genes, 2 rRNA genes, and 22 tRNA genes. The GC composition in both species was above 40%. In order to investigate the phylogenetic relationships of two different spine-color individuals, a comprehensive analysis was conducted using eight complete mitochondrial genomic sequences of the genus Tripneustes on the software MEGA X. It was observed that the two spine color types of T. gratilla species showed a high similarity of 98.91%. However, different color-spined species of T. gratilla were found in separate branches of the phylogenetic tree of the same sea urchin species.
Perspectives of Orthoptists Working with Patients with Communication Impairments

Aims: To survey orthoptists’ confidence in communicating with patients with communication impairments and to investigate resources orthoptists are currently using to aid assessment and management and to explore future resources that may be beneficial. Methods and Procedures: Practicing orthoptists (n = 63; median age range: 31–35 years old) completed an online survey with quantitative and qualitative questions which investigated approaches to adult and paediatric patients with communication impairments and any communication tools used. Analysis of quantitative survey responses was conducted using IBM SPSS v27. Content analysis of qualitative responses was done. Outcomes and Results: Simple communication strategies (e.g., eye contact and body language, repeating/rephrasing sentences) were commonly used with both adult and paediatric patients while more complex strategies (e.g., electronic visual aids, writing key words/concepts) were rarely used. Usage of communication strategies was not affected by length of work experience, workplace clinical speciality or training during their clinical degree or after graduation (p < 0.05). Most participants (71.2%) reported being unaware of resources available for orthoptists to assist in the assessment and management of patients with communication impairments. Conclusions and Implications: Orthoptists have adopted some communication strategies to improve their interactions with patients with communication impairments, despite limited resources. With proper resources, such as training in supportive communication techniques, they can provide optimal patient care, making it essential to identify what kind of resources would be most appropriate.
Changes in the Land

The Telliamed scandalized the orthodox and even aroused strong opposition from the not so orthodox when it appeared in 1748. Benoit de Maillet's critics were repelled by the materialistic cosmogony which was quite apparent throughout the work in spite of the efforts of his. editor and literary executor, the Abbe Jean-Baptiste Ie Mascrier, to soften its heterodoxy. Thanks to the attacks of its critics, the Telliamed received extensive publicity and was widely read. For nearly a century it stimulated debates and influenced men of far greater ability than its author. The Telliamed begins as a treatise on geology, but it concludes with a remarkable discussion of the origins of the earth and stars and a hypothesis concerning the appearance and transformation of terrestrial life. The work is in the form of three conversations between a French missionary and an Indian sage who proposes de Maillet's heretical ideas. The geological system presented in the first two conversations attempts to explain virtually all of the earth's physiographic and structural characteristics as the results of the action and gradual diminution of the seas. Each of these conversations contains an array of detailed observations supporting plausible inductive generalizations. The third conversation, however, is quite different in both character and content. It contains a cosmogony based upon Cartesian vortices, the plurality of worlds, and a series of cyclical cosmic changes through which celestial bodies pass from stars to globes completely covered by water, to habitable planets, and back to stars. It also presents de Maillet's arguments for the aquatic origin of all life including man
The state of the art of the english language teaching in Belén de Umbría (Risaralda)

The present study “The state of the art of the English language teaching in Belen de Umbria” is a qualitative case study that made use of a descriptive procedure. The study was conducted in two public institutions of Belen de Umbria, Colombia. The objective of this study was to represent and describe the realities of the English teaching in public institutions, with the purpose of establishing a reference that will contribute to the development of the next phases of the project Risaralda Bilingue. Another purpose that guided this study was to reveal, expose and report on behaviors, strategies and procedures implemented in English teaching scenarios that take place in Public High Schools in Belen de Umbria Risaralda The data were gathered through the use of observations, questionnaires and interviews. The collected data was analyzed in order to obtain the findings that gave answers to the following questions: Which are the approaches, methods, and techniques implemented in state Schools in Belen de Umbria? What are teachers’ and stakeholders’ perceptions towards English Language Teaching? Data analysis shows the following results: 1. English Language class development in public scenarios 2. Students’ perception towards the English language class and the language teacher 3. Learners’ practice of English outside of the classroom.
Statistical analysis of the storage time of finished product infusion

Objective This retrospective study determined the storage time of finished infusion in each hospital ward and assessed whether the storage time of finished infusion was within an acceptable range. Methods The research object was the finished infusion (one bag of infusion with only one drug) that is centrally dosed at the Pharmacy Intravenous Admixture Service (PIVAS) of Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences. We used an automatic scanner to assess the placement time of finished infusion products in various wards of the hospital. We classified the drugs used in various wards, analyzed whether their placement times were reasonable, assessed the reasons for unreasonable placement times, and took intervention measures. Similarly, the storage time of finished infusion was deemed reasonable or unreasonable, the reasons for unreasonable storage times were analyzed, and intervention measures were taken. Results In September 2021, the proportion of infusions stored for an unreasonable time was 12.69%, a decrease of 5.37% compared with August 2021, indicating the effectiveness of intervention measures. Conclusion By using statistical analysis and intervention measures, our PIVAS improved the standardized use of finished infusion products and ensured the safety of medication for patients.
The Ability to Voluntarily Regulate Theta Band Activity Affects How Pharmacological Manipulation of the Catecholaminergic System Impacts Cognitive Control

Abstract Background The catecholaminergic system influences response inhibition, but the magnitude of the impact of catecholaminergic manipulation is heterogeneous. Theoretical considerations suggest that the voluntary modulability of theta band activity can explain this variance. The study aimed to investigate to what extent interindividual differences in catecholaminergic effects on response inhibition depend on voluntary theta band activity modulation. Methods A total of 67 healthy adults were tested in a randomized, double-blind, cross-over study design. At each appointment, they received a single dose of methylphenidate or placebo and performed a Go/Nogo task with stimuli of varying complexity. Before the first appointment, the individual’s ability to modulate theta band activity was measured. Recorded EEG data were analyzed using temporal decomposition and multivariate pattern analysis. Results Methylphenidate effects and voluntary modulability of theta band activity showed an interactive effect on the false alarm rates of the different Nogo conditions. The multivariate pattern analysis revealed that methylphenidate effects interacted with voluntary modulability of theta band activity at a stimulus processing level, whereas during response selection methylphenidate effects interacted with the complexity of the Nogo condition. Conclusions The findings reveal that the individual’s theta band modulability affects the responsiveness of an individual’s catecholaminergic system to pharmacological modulation. Thus, the impact of pharmacological manipulation of the catecholaminergic system on cognitive control most likely depends on the existing ability to self-modulate relevant brain oscillatory patterns underlying the cognitive processes being targeted by pharmacological modulations.
Will synchronous esophageal and lung resection increase the incidence of anastomotic leaks? A multicenter retrospective study

Background: Reports on combined resection for synchronous lung lesions and esophageal cancer (CRLE) cases are rare and mostly individual cases. Furthermore, the feasibility of CRLE has always been a controversial topic. In the current study, the authors retrospectively analyzed the feasibility of CRLE and established an individualized prediction model for esophageal anastomotic leaks after CRLE by performing a multicenter retrospective study. Methods: Patients who underwent esophagectomy between January 2009 and June 2021 were extracted from a four-center prospectively maintained database, and those with CRLE at the same setting were matched in a 1:2 propensity score-matched (PSM) ratio to esophagectomy alone (EA) patients. A nomogram was then established based on the variables involved in multivariate logistic regression analysis. Internal validation of the nomogram was conducted utilizing Bootstrap resampling. Decision and clinical impact curve analysis were computed to assess the practical clinical utility of the nomogram. A prognosis analysis for CRLE and EA patients by Kaplan–Meier curves was conducted. Results: Of the 7152 esophagectomies, 216 cases of CRLE were eligible, and 1:2 ratio propensity score-matched EA patients were matched. The incidence of anastomotic leaks following CRLE increased significantly (P=0.035). The results of the multivariate analysis indicated the leaks varied according to the type of lung resection (anatomic>wedge resection, P=0.016) and site of resected lobe (upper>middle/low lobe; P=0.027), and a nomogram was established to predict the occurrence of leaks accurately (area under the curve=0.786). Although no statistically significant difference in overall survival (OS) was observed in the CRLE group (P=0.070), a trend toward lower survival rates was noted. Further analysis revealed that combined upper lobe anatomic resection was significantly associated with reduced OS (P=0.027). Conclusion: Our study confirms that CRLE is feasible but comes with a significantly increased risk of anastomotic leaks and a concerning trend of reduced survival, particularly when upper lobe anatomic resections are performed. These findings highlight the need for careful patient selection and surgical planning when considering CRLE.