Miracle-dz/UniFAR-FTUs huggingface dataset:
A Dual‐Channel Deep Learning Approach for Lung Cavity Estimation From Hyperpolarized Gas and Proton MRI

Hyperpolarized gas MRI can quantify regional lung ventilation via biomarkers, including the ventilation defect percentage (VDP). VDP is computed from segmentations derived from spatially co‐registered functional hyperpolarized gas and structural proton (1H)‐MRI. Although acquired at similar lung inflation levels, they are frequently misaligned, requiring a lung cavity estimation (LCE). Recently, single‐channel, mono‐modal deep learning (DL)‐based methods have shown promise for pulmonary image segmentation problems. Multichannel, multimodal approaches may outperform single‐channel alternatives.
Prophylactic Left Atrial Appendage Exclusion in Cardiac Surgery Patients With Elevated CHA2DS2-VASc Score: Results of the Randomized ATLAS Trial

Objective: Patients with elevated CHA2DS2-VASc scores are at high risk for atrial fibrillation (AF) and thromboembolic events (TE) after cardiac surgery. Left atrial appendage exclusion (LAAE) is a permanent, continuous approach to stroke prevention in AF, overcoming limitations of oral anticoagulation (OAC). We report ATLAS trial results focused on LAAE technical success and perioperative safety and TE rates with and without LAAE in cardiac surgery patients who developed postoperative AF (POAF). Methods: ATLAS (NCT02701062) was a prospective, multicenter, feasibility trial. Patients age ≥18 years, undergoing structural heart procedure, with no preoperative AF, CHA2DS2-VASc ≥2, and HAS-BLED ≥2 were randomized 2:1 to LAAE or no LAAE. Patients who developed POAF and/or received LAAE were followed for 1 year. LAAE was evaluated with intraoperative transesophageal echocardiography. Results: A total of 562 patients were randomized to LAAE (n = 376) or no LAAE (n = 186). Mean CHA2DS2-VASc (3.4 vs 3.4) and HAS-BLED (2.8 vs 2.9) scores were similar for LAAE and no LAAE groups. LAAE success (no flow nor residual stump >10 mm) was 99%. One LAAE-related serious adverse event (0.27%) occurred and was resolved without sequelae. There were 44.3% of patients who developed POAF. Through 1 year, 3.4% of LAAE patients and 5.6% of no LAAE patients had TE. OAC was used by 32.5% of POAF patients. Bleeding was higher with OAC than without (16.1% vs 5.4%, P = 0.008). Conclusions: ATLAS demonstrated a high rate of successful LAAE with low LAAE-related serious adverse events in cardiac surgery patients. Study results should be considered in future trial design to further evaluate prophylactic LAAE for stroke prevention in cardiac surgery patients with elevated stroke risk.
The effect of dietary carbohydrate restriction and aerobic exercise on retinol binding protein 4 (RBP4) and fatty acid binding protein 5 (FABP5) in middle-aged men with metabolic syndrome

Abstract Exercise and dietary interventions have been described to positively affect metabolic syndrome (MetS) via molecular-induced changes. The purpose of this study was to investigate the effects of dietary carbohydrate restriction and aerobic exercise (AE) on retinol binding protein 4 (RBP4) and fatty acid binding protein 5 (FABP5) in middle-aged men with MetS. The study had a randomised, double-blinded, parallel-controlled design. Forty middle-aged men with MetS (age: 53·97 ± 2·85 years, BMI = 31·09 ± 1·04 kg/m2) were randomly assigned to four groups, AE (n 10), ketogenic diet (KD; n 10), AE combined with KD (AE + KD; n 10) or control (C; n 10). RBP4, FABP5, body composition (body mass, BMI and body fat), insulin resistance, insulin sensitivity and MetS factors were evaluated prior to and after the 12-week intervention. AE + KD significantly decreased the body fat percentage (P = 0·006), BMI (P = 0·001), Zmets (P = 0·017), RBP4 (P = 0·017) and the homeostasis model of insulin resistance (HOMA-IR) (P = 0·001) as compared with control group and marginally significantly decreased the Zmets as compared with exercise group (P = 0·086). KD significantly decreased RBP4 levels as compared with control group (P = 0·041). Only the AE intervention (P = 0·045) significantly decreased FABP5 levels. Combining intervention of carbohydrate restriction with AE compared with carbohydrate restriction and AE alone improved RBP4, HOMA-IR as well as different body composition and MetS factors in middle-aged men with MetS.
THE SUPERMASSIVE BLACK HOLE AND DARK MATTER HALO OF NGC 4649 (M60)

We apply the axisymmetric orbit superposition modeling to estimate the mass of the supermassive black hole (BH) and dark matter (DM) halo profile of NGC 4649. We have included data sets from the Hubble Space Telescope (HST), stellar, and globular cluster (GC) observations. Our modeling gives M• = (4.5 ± 1.0) × 109 M☉ and M/LV, obs = 8.7 ± 1.0 (or M/LV = 8.0 ± 0.9 after foreground Galactic extinction is corrected). We confirm the presence of a DM halo, but the stellar mass dominates inside the effective radius. The parameters of the dark halo are less constrained due to the sparse GC data at large radii. We find that in NGC 4649 the dynamical mass profile from our modeling is consistently larger than that derived from the X-ray data over most of the radial range by roughly 60%–80%. It implies that either some forms of non-thermal pressure need to be included, the assumed hydrostatic equilibrium may not be a good approximation in the X-ray modelings of NGC 4649, or our assumptions used in the dynamical models are biased. Our new M• is about 2 times larger than the previous published value; the earlier model did not adequately sample the orbits required to match the large tangential anisotropy in the galaxy center. If we assume that there is no DM, the results on the BH mass and M/LV, obs do not change significantly, which we attribute to the inclusion of HST spectra, the sparse GC kinematics, and a diffuse DM halo. Without the HST data, the significance of the BH detection is greatly reduced.
Observation of persistent centrosymmetricity in the hexagonal manganite family

The controversy regarding the ferroelectric behavior of hexagonal InMnO3 is resolved by using a combination of x-ray diffraction (XRD), piezoresponse force microscopy (PFM), second harmonic generation (SHG), and density functional theory (DFT). While XRD data show a symmetry-lowering unit-cell tripling, which is also found in the multiferroic hexagonal manganites of P6(3)cm symmetry, PFM and SHG do not detect ferroelectricity at ambient or low temperature, in striking contrast to the behavior in the multiferroic counterparts. We propose instead a centrosymmetric P (3) over barc phase as the ground-state structure. Our DFT calculations reveal that the relative energy of the ferroelectric and nonferroelectric structures is determined by a competition between electrostatics and oxygen-rare-earth covalency, with an absence of covalency favoring the ferroelectric phase.
Three-dimensional analysis of wakefields generated by flat electron beams in planar dielectric-loaded structures

An electron bunch passing through dielectric-lined waveguide generates $\check{C}$erenkov radiation that can result in high-peak axial electric field suitable for acceleration of a subsequent bunch. Axial field beyond Gigavolt-per-meter are attainable in structures with sub-mm sizes depending on the achievement of suitable electron bunch parameters. A promising configuration consists of using planar dielectric structure driven by flat electron bunches. In this paper we present a three-dimensional analysis of wakefields produced by flat beams in planar dielectric structures thereby extending the work of Reference [A. Tremaine, J. Rosenzweig, and P. Schoessow, Phys. Rev. E 56, No. 6, 7204 (1997)] on the topic. We especially provide closed-form expressions for the normal frequencies and field amplitudes of the excited modes and benchmark these analytical results with finite-difference time-domain particle-in-cell numerical simulations. Finally, we implement a semi-analytical algorithm into a popular particle tracking program thereby enabling start-to-end high-fidelity modeling of linear accelerators based on dielectric-lined planar waveguides.
Atrial Fibrillation Risk Assessment after Embolic Stroke of Undetermined Source

Approximately 20% of strokes are embolic strokes of undetermined source (ESUS). Undetected atrial fibrillation (AF) remains an important cause. Yet, oral anticoagulation in unselected ESUS patients failed in secondary stroke prevention. Guidance on effective AF detection is lacking. Here, we introduce a novel, non‐invasive AF risk assessment after ESUS.
Can the Fenestrated Anaconda™ salvage failed competitor endografts? An international frame of reference

Introduction An abdominal aortic aneurysm (AAA) is a life-threatening abnormal dilation of the abdominal aorta that can be repaired either endovascularly or with open surgery. However, endovascular aortic repair (EVAR) has become the main treatment modality for AAA due to its more optimal results. EVAR devices can either be standard, fenestrated, or branched, with fenestrated EVAR (FEVAR) seemingly achieving superior prospects. Although EVAR is associated with excellent outcomes, it still carries a risk of certain complications requiring reintervention or ‘rescue’. Several commercial EVAR devices are available on the global market, nevertheless, the Fenestrated Anaconda developed by Terumo Aortic can be considered the superior device due to the wide range of endovascular solutions that it offers along with its unique custom-made approach, excellent results and its highly promising potential to be used as a ‘rescue’ device for failed competitor endografts. Materials and methods The current study represents a 9-year cross-sectional international analysis of a custom-made Fenestrated Anaconda™ device. For the statistical analysis, SPSS 28 for Windows and R were utilised. Pearson Chi-square analysis was used to assess differences in cumulative distribution frequencies between select variables. Statistical significance for all two-tailed tests was set at p < 0.05. Results Out of 5058 EVARs performed using the Fenestrated Anaconda, 2987 (59%) were ‘rescue’ procedures for migrated Gore (n = 252) and Medtronic (n = 2735) devices. The Fenestrated Anaconda™ was indicated as the reintervention device either due to unsuitable/complex anatomy for the competitor (n = 2411) or based on surgeon preference (n = 576). Overall, the Fenestrated Anaconda was utilised to rescue 3466 (68.5%) failed previous EVARs using competitor devices. Yet, the primary endovascular solution offered by the Fenestrated Anaconda was FEVAR (91.3%), with 112 (2.2%) devices using custom-made iliac stents. Discussion The use of the Fenestrated Anaconda endograft as a ‘rescue’ device to salvage failed competitor devices is well-established in the literature with excellent clinical outcomes achieved. The evidence in the literature also highlights the distinctive custom-made approach that the Fenestrated Anaconda offers which enables it to treat extremely complex aortic anatomy.
Evolved star water maser cloud size determined by star size

Cool, evolved stars undergo copious mass loss but the details of how the matter is returned to the ISM are still under debate. We investigated the structure and evolution of the wind at 5 to 50 stellar radii from Asymptotic Giant Branch and Red Supergiant stars. 22-GHz water masers around seven evolved stars were imaged using MERLIN, at sub-AU resolution. Each source was observed at between 2 and 7 epochs (several stellar periods). We compared our results with long-term Pushchino single dish monitoring. The 22-GHz emission is located in ~spherical, thick, unevenly filled shells. The outflow velocity doubles between the inner and outer shell limits. Water maser clumps could be matched at successive epochs separated by <2 years for AGB stars, or at least 5 years for RSG. This is much shorter than the decades taken for the wind to cross the maser shell, and comparison with spectral monitoring shows that some features fade and reappear. In 5 sources, most of the matched features brighten or dim in concert from one epoch to the next. One cloud in W Hya was caught in the act of passing in front of a background cloud leading to 50-fold, transient amplification. The masing clouds are 1-2 orders of magnitude denser than the wind average and contain a substantial fraction of the mass loss in this region, with a filling factor <1%. The RSG clouds are ~10x bigger than those round the AGB stars. Proper motions are dominated by expansion, with no systematic rotation. The maser clouds survive for decades (the shell crossing time) but the masers are not always beamed in our direction. Radiative effects cause changes in flux density throughout the maser shells on short timescales. Cloud size is proportional to parent star size; clouds have a similar radius to the star in the 22-GHz maser shell. Stellar properties such as convection cells must determine the clumping scale.
Partial covering of the emission regions of Q 0528−250 by intervening H2 clouds

We present an analysis of the molecular hydrogen absorption system at zabs = 2.811 in the spectrum of the blazar Q0528 250. We demonstrate that the molecular cloud does not cover the background source completely. The partial coverage reveals itself as a residual flux in the bottom of saturated H2 absorption lines. This amounts to about (2.22±0.54)% of the continuum and does not depend on the wavelength. This value is small and it explains why this effect has not been detected in previous studies of this quasar spectrum. However, it is robustly detected and significantly higher than �
Weak hyperbolicity of cube complexes and quasi‐arboreal groups

We examine a graph Γ encoding the intersection of hyperplane carriers in a CAT(0) cube complex X~ . The main result is that Γ is quasi‐isometric to a tree. This implies that a group G acting properly and cocompactly on X~ is weakly hyperbolic relative to the hyperplane stabilizers. Using Wright's recent result on the asymptotic dimension of CAT(0) cube complexes, we give a generalization of a theorem of Bell and Dranishnikov on the finite asymptotic dimension of graphs of asymptotically finite‐dimensional groups. Finally, we apply contact graph techniques to prove a cubical version of the flat plane theorem stated in terms of complete bipartite subgraphs of Γ.
Discovery of a new subparsec counterjet in NGC 1275: the inclination angle and the environment

We report the detection of a new feature at the centre of NGC 1275 in the Perseus cluster, hosting the radio source 3C 84. This feature emerges ~ 2 mas (~ 0.8 pc) north of the central core in recent 15 and 43 GHz VLBA images, and seems to be the counterjet to a known radio jet expanding to the south of the core. Apparently, the two jets were born through an outburst around 2005. From the ratio of the apparent lengths of the two jets from the core, we found that the jet angle to the line of sight is \theta=65^\circ\pm 16^\circ, which is not much different from the angle of the outer jets generated by an activity around 1959 and constrains theories on gamma-ray emission from jets. The new northern jet has a strongly inverted spectrum in contrast with the southern jet. This suggests that the central black hole is surrounded by a subparsec-scale accretion disk with the density of >~ 10^5 cm^-3. The brightness of the counterjet suggests that the disk is highly inhomogeneous. The ambient gas density in the direction of the jet is ~ 8 cm^-3 if the current jet activity is similar to the past average.
Two-point discrimination responses in children with idiopathic toe walking: A feasibility fMRI study

Idiopathic toe walking (ITW) is a diagnosis given to children who walk with an absence or limitation of heel strike in the contact phase of the gait cycle, that are otherwise typically developing. There is emerging evidence that this gait pattern may occur in children who experience tactile sensory processing challenges. This feasibility study aimed to determine if children were able to respond to a sensory stimulus during a fMRI. Children aged between 8–16 years of age, with and without idiopathic toe walking were recruited from general public advertising. Participants were required to perform a two-point discrimination test (task block) and press a button without being tested (control block) during an fMRI using a standard block design. Activation differences were examined in the left frontal pole, left supramarginal gyrus, left parahippocampal gyrus, left paracingulate gyrus and the right superior temporal. Five children were in the typically developing (TD) group and three were in the ITW group. There were between-group activation differences in the decision-making block compared to the control block in the left frontal lobe, parahippocampal gyrus and the right superior temporal gyrus. There was greater variation in activation in the left supramarginal gyrus and the left paracingulate gyrus in the ITW group compared to the typically developing group. Based on this study a future sample size of 15 children per group will be required to detect an adequate effect across chosen regions of interest Conducting fMRI using two-point discrimination testing on this population is feasible. Further research is required with larger population sizes to determine if brain activation patterns during the sensory input decision-making process are different in this population.
COMPARATIVE SPECTRA OF OXYGEN-RICH VERSUS CARBON-RICH CIRCUMSTELLAR SHELLS: VY CANIS MAJORIS AND IRC +10216 AT 215–285 GHz

A sensitive (1σ rms at 1 MHz resolution ∼3 mK) 1 mm spectral line survey (214.5–285.5 GHz) of VY Canis Majoris (VY CMa) and IRC +10216 has been conducted to compare the chemistries of oxygen- and carbon-rich circumstellar envelopes. This study was carried out using the Submillimeter Telescope of the Arizona Radio Observatory with a new Atacama Large Millimeter Array type receiver. This survey is the first to chemically characterize an O-rich circumstellar shell at millimeter wavelengths. In VY CMa, 128 emission features were detected arising from 18 different molecules; and in IRC +10216, 720 lines were observed, assigned to 32 different species. The 1 mm spectrum of VY CMa is dominated by SO2 and SiS; in IRC +10216, C4H and SiC2 are the most recurrent species. Ten molecules were common to both sources: CO, SiS, SiO, CS, CN, HCN, HNC, NaCl, PN, and HCO+. Sulfur plays an important role in VY CMa, but saturated/unsaturated carbon dominates the molecular content of IRC +10216, producing CH2NH, for example. Although the molecular complexity of IRC +10216 is greater, VY CMa supports a unique “inorganic” chemistry leading to the oxides PO, AlO, and AlOH. Only diatomic and triatomic compounds were observed in VY CMa, while species with four or more atoms are common in IRC +10216, reflecting carbon's ability to form multiple strong bonds, unlike oxygen. In VY CMa, a new water maser (v2 = 2) has been found, as well as vibrationally excited NaCl. Toward IRC +10216, vibrationally excited CCH was detected for the first time.
Quantifying and mathematical modelling of the influence of soluble adenylate cyclase on cell cycle in human endothelial cells with Bayesian inference

Adenosine‐3′, 5′‐cyclic monophosphate (cAMP) produced by adenylate cyclases (ADCYs) is an established key regulator of cell homoeostasis. However, its role in cell cycle control is still controversially discussed. This study focussed on the impact of soluble HCO3− ‐activated ADCY10 on cell cycle progression. Effects are quantified with Bayesian inference integrating a mathematical model and experimental data. The activity of ADCY10 in human umbilical vein endothelial cells (HUVECs) was either pharmacologically inhibited by KH7 or endogenously activated by HCO3−. Cell numbers of individual cell cycle phases were assessed over time using flow cytometry. Based on these numbers, cell cycle dynamics were analysed using a mathematical model. This allowed precise quantification of cell cycle dynamics with model parameters that describe the durations of individual cell cycle phases. Endogenous inactivation of ADCY10 resulted in prolongation of mean cell cycle times (38.7 ± 8.3 h at 0 mM HCO3− vs 30.3 ± 2.7 h at 24 mM HCO3−), while pharmacological inhibition resulted in functional arrest of cell cycle by increasing mean cell cycle time after G0/G1 synchronization to 221.0 ± 96.3 h. All cell cycle phases progressed slower due to ADCY10 inactivation. In particular, the G1‐S transition was quantitatively the most influenced by ADCY10. In conclusion, the data of the present study show that ADCY10 is a key regulator in cell cycle progression linked specifically to the G1‐S transition.
The molecular profile of breast cancer: primary tumor versus corresponding lymph node metastases

Breast cancer (BrCa) is the most frequent malignancy in female, and lymph node metastases (LNM) is an important prognostic and therapeutic parameter. The molecular classification is nowadays largely applied to characterize the primary tumors, but few studies focused on the comparison between the molecular profiles of the primary with corresponding LNM. In the current work, we investigated the expression of conventional markers used by molecular classification in both primary tumors and axillary LNM. A series of 156 patients with BrCa was investigated, and from these 80 cases showed LNM. After routine pathological investigation, including the histopathological form and grade, we performed additional step sections from the primary and lymph nodes for immunohistochemistry. All procedures for hormone receptors, human epidermal growth factor receptor 2 (HER2), Ki67, cytokeratin 5 (CK5), epidermal growth factor receptor (EGFR), p53, E-cadherin, and B-cell leukemia/lymphoma-2 (Bcl-2) were performed using the standard automated procedures. We found significant differences between the primary tumors and corresponding LNM in luminal A, luminal B, and basal-like carcinoma. No phenotypical interconversions were noticed in HER2 and unclassified BrCa. Our data demonstrate that in almost 20% of the cases the molecular profile of the primary does not overlap with aspects found in the lymph nodes. Our results strongly suggest performing the molecular classification in both primary tumors and in LNM. Current data suggest that the application of this diagnostic procedure will significantly influence the therapeutic strategy.
Oblique corrections from less-Higgsless models in warped space

The Higgsless model in warped extra dimension is reexamined. Dirichlet boundary conditions on the TeV brane are replaced with Robin boundary conditions which are parameterized by a mass parameter $M$. We calculate the Peskin-Takeuchi precision parameters $S$, $T$ and $U$ at tree level. We find that to satisfy the constraints on the precision parameters at $99 \%$ [$95 \%$] confidence level (CL) the first Kaluza-Klein excited $Z$ boson, $Z'$, should be heavier than 5 TeV [8 TeV]. The Magnitude of $M$, which is infinitely large in the original model, should be smaller than 200 GeV (70 GeV) for the curvature of the warped space $R^{-1}=10^{16}$ GeV ($10^{8}$ GeV) at $95\%$ CL. If the Robin boundary conditions are induced by the mass terms localized on the TeV brane, from the $99\%$ [$95\%$] bound we find that the brane mass interactions account for more than $97\%$ [$99\%$] of the masses of $Z$ and $W$ bosons. Such a brane mass term is naturally interpreted as a vacuum expectation value of the Higgs scalar field in the standard model localized on the TeV brane. If so, the model can be tested by precise measurements of $HWW$, $HZZ$ couplings and search for 1st Kaluza-Klein excited states.