Miracle-dz/UniFAR-FTUs huggingface dataset:
Inseguridad en las redes sociales e internet: formando en la apropiación segura de las TIC

Las politicas del gobierno nacional y regional facilitan el acceso a las TIC en el pais, especialmente en la educacion y, el aumento de equipos de computo, tablets y conexion a Internet en los hogares colombianos, generando que la edad en que los ninos se inician en el uso del Internet y las redes sociales sea cada vez menor. Los ninos y profesores son instruidos en el uso de estas tecnologias, pero queda un vacio de conocimiento en el uso adecuado de la informacion en estas plataformas. El proyecto Inseguridad en las redes sociales e Internet surge con el proposito de crear un espacio de formacion en las instituciones educativas a traves de la sensibilizacion y el uso de las TIC como componente social para el fortaleciento de la conciencia digital en los infantes que cursaban los grados cuarto y quinto de las instituciones educativas en la provincia de Ocana, Colombia. Los resultados obtenidos a traves de una herramienta de diagnostico muestran el desconocimiento de las buenas practicas en el manejo adecuado de estas plataformas; esto a causa de la ignorancia de las personas que incluyen a los ninos en el mundo de la tecnologia. No es suficiente proporcionar a las escuelas y hogares recursos TIC, si los usuarios no estan capacitados en temas del uso correcto y seguro de la informacion utilizada en estos espacios.
Duloxetine in the treatment of generalized anxiety disorder

Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI) which is FDA approved for the treatment of generalized anxiety disorder (GAD) in doses of 30 mg to 120 mg daily. Duloxetine has been shown to significantly improve symptoms of GAD as measured through the Hamilton Anxiety Rating Scale (HAMA), the Clinical Global Impressions Scale (CGI-I), and other various outcome measures in several placebo-controlled, randomized, double blind, multi-center studies. Symptom improvement began within the first few weeks, and continued for the duration of the studies. In addition, duloxetine has also been shown to improve outcomes in elderly patients with GAD, and in GAD patients with clinically significant pain symptoms. Duloxetine was noninferior compared with venlafaxine XR. Duloxetine was found to have a good tolerability profile which was predictable and similar to another SNRI, venlafaxine. Adverse events (AEs) such as nausea, constipation, dry mouth, and insomnia were mild and transient, and occurred at relatively low rates. It was found to have a low frequency of drug interactions. In conclusion, duloxetine, a selective inhibitor for the serotonin and norepinephrine transporters, is efficacious in the treatment of GAD, and has a predictable tolerability profile, with AEs generally being mild to moderate.
Voltage responsive distribution networks: Comparing autonomous and centralized solutions

Power system voltage control has traditionally been the responsibility of transmission-connected reactive power resources. Accordingly, high penetration levels of distributed generation present new challenges for reactive power management. Simply stipulating voltage control operation for distributed generators will not generally deliver voltage-responsive reactive power flows at the transmission system level, due mainly to the voltage-isolating effects of tap-changing bulk supply transformers. Additionally, the resistance of distribution system conductors establishes an unhelpful interaction between active power flows and voltage magnitudes. This work uses optimal power flow techniques to explore two ways to overcome these challenges. Most innovatively, a methodology is presented to optimally select static voltage control settings for distributed generators and transformers, such that they will provide an autonomous voltage-responsive behaviour without supervisory control systems. In this scheme, distributed generators are exposed to transmission voltage fluctuations as far as is feasible, by blocking the tapping of the bulk supply transformer when operating within an optimally-determined range of transmission voltages. Comparatively, an active control scheme is presented, where reactive power and tap positions are dispatched period-to-period to support the transmission system voltage. Comparing these approaches suggests the level of smart-grids investment required to effectively harness the reactive power available from distributed generation.
El concepto de lo innato en la psicología evolucionista

Some of the literature pertaining to certain evolutionary cognitive disciplines is here reviewed.It is shown that there is at least one important connotation associated to the term “innate” as it is used in those disciplines; to wit, that an innate feature is one which is the product of evolution by natural selection. Then three recent proposals are examined characterizing innateness through concepts and ideas from biology —i.e., Andre Ariew’s, WilliamWimsatt’s and mine—and conclude that, although Ariew’s and Wimsatt’s proposals capture the aforementioned evolutionary connotation, they must be rejected since they either have serious internal problems, or else are incompatible with other important connotations associated to the term innate in evolutionary cognitive disciplines. It is also shown in this paper that my proposal does not share the problems that the previous ones had, but does share some of their advantages.
The Effect of Emotion on Time Perception for Complex Visual Stimuli

Activation and attention have opposite effects on time perception. Emotion can both increase physiological activation (which leads to overestimation of time) and attract attention (which leads to underestimation of time). Although the effect of emotion on time perception has received a growing amount of attention, the use of different time estimation tasks and stimuli makes it difficult to compare findings across studies. The effect of emotion on the temporal perception of complex stimuli (e.g. scenes) is particularly under-researched. This thesis presents a systematic assessment of the effect of two key emotional dimensions, arousal and valence, on time perception for visual stimuli. Studies were designed to control for factors that may modulate emotion effects, such as image repetition and carry over from one emotion to another. The stimuli were complex images standardized for arousal (high or low) and valence (positive or negative) as well as neutral images. The first study compared three time estimation tasks to determine which were sensitive to emotion effects. The selected task, temporal bisection, was used to test time perception in three duration ranges: short (400 to 1600ms), middle (1000 to 4000ms), and long (2000 to 6000ms). Results of bisection point analyses revealed that the duration of attention-capturing stimuli (e.g. high arousal or negative images) was underestimated compared to that of other stimuli (e.g. low arousal or neutral images). These findings are at odds with activational effects of emotion (overestimation of emotional stimuli), which are typically found in studies of time perception for facial expression. Better temporal sensitivity in the long range than in short and middle ranges suggests that participants used different timing strategies to perform the bisection task at longer stimulus durations. To test the effect of emotion on time perception using a discrete rather than dimensional classification of emotion, experiments were replicated using emotional facial expressions as stimuli. Time estimates in the short and middle ranges did not show attentional effects, but pointed to activational effects of emotion. Facial expression had no impact on time perception in the long duration range. Taken together, these experiments show that the effect of emotion on time perception varies according to both duration and stimulus type. Emotional facial expressions have short lived activational effects whereby the duration of arousing stimuli is overestimated, whereas complex emotional scenes have protracted attentional effects through which the duration of attention-capturing stimuli is underestimated.
The statistical analysis of star clusters

We review a range of statistical methods for analysing the structures of star clusters, and derive a new measure , which both quantifies and distinguishes between a (relatively smooth) large-scale radial density gradient and multiscale (fractal) subclustering. The distribution of separations p(s) is considered, and the normalized correlation length (i.e. the mean separation between stars, divided by the overall radius of the cluster) is shown to be a robust indicator of the extent to which a smooth cluster is centrally concentrated. For spherical clusters having volume-density n? r? (with between 0 and 2) decreases monotonically with , from ? 0.8 to ? 0.6. Since reflects all star positions, it implicitly incorporates edge effects. However, for fractal star clusters (with fractal dimension D between 1.5 and 3) decreases monotonically with D (from ? 0.8 to ? 0.6). Hence , on its own, can quantify, but cannot distinguish between, a smooth large-scale radial density gradient and multiscale (fractal) subclustering. The minimal spanning tree (MST) is then considered, and it is shown that the normalized mean edge length [i.e. the mean length of the branches of the tree, divided by , where A is the area of the cluster and is the number of stars] can also quantify, but again cannot on its own distinguish between, a smooth large-scale radial density gradient and multiscale (fractal) subclustering. However, the combination does both quantify and distinguish between a smooth large-scale radial density gradient and multiscale (fractal) subclustering. IC348 has and ? Ophiuchus has , implying that both are centrally concentrated clusters with, respectively, ? 2.2
Digital Youth: The Role of Media in Development

Digital Youth: The Role of Media in Development recognizes the important role of digital tools in the lives of teenagers and presents both the risks and benefits of these new interactive technologies. From social networking to instant messaging to text messaging, the authors create an informative and relevant guidebook that goes beyond description to include developmental theory and implications. Also woven throughout the book is an international sensitivity and understanding that clarifies how, despite the widespread popularity of digital communication, technology use varies between groups globally. Other specific topics addressed include: Sexuality on the Internet. Online identity and self-presentation. Morality, ethics, and civic engagement. Technology and health. Violence, cyberbullying, and victimization. Excessive Internet use and addictive behavior.
O Índice de Capital Social Empresarial (ICSE) na Área de Livre Comércio de Guajará-Mirim, Rondônia: Uma Análise a Partir da Teoria do Desenvolvimento Endógeno

O presente trabalho foi derivado da pesquisa sobre a desigualdade regional em Rondonia. O problema de pesquisa ficou centrado na seguinte indagacao cientifica: Qual o nivel de capital social empresarial existente em Guajara-Mirim? Que relacao existe entre esse indice e a realidade municipal? Foi utilizada a analise fatorial, metodo Varimax, para a construcao dos indices de capital social, os quais foram derivados de 51 questionarios aplicados ao empresariado local. As dimensoes do ICSE estudadas foram: a) grupos e redes, b) confianca e solidariedade, c) acao coletiva e cooperacao, d) informacao e comunicacao, e) coesao e inclusao social e f) empowerment . Pelo trabalho pode-se concluir que o referido indice, ao apontar rendimento relativamente baixo. O parâmetro “cooperacao” foi o mais critico de todos, configurando-se no principal entrave do desenvolvimento endogeno na regiao. Ficou evidenciado, ainda, pelo parâmetro empowerment , que os empresarios da Area de Livre Comercio de Guajara-Mirim demonstram uma relacao muito significativa com o setor politico, o que permitiu concluir que o comercio local nao e determinado somente pelo mercado concorrencial e, sim, por uma relacao de barganha politica
Noradrenergic-Specific Transcription of the Dopamine β-Hydroxylase Gene Requires Synergy of MultipleCis-Acting Elements Including at Least Two Phox2a-Binding Sites

Dopamine β-hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline and is selectively expressed in noradrenergic and adrenergic neurons and neuroendocrine cells. Recent data from this laboratory showed that a paired-like homeodomain (HD) protein, Phox2a, interacts with the HD-binding site residing within a composite promoter of the human DBH gene, designated domain IV, in a cell-specific manner and directly controls noradrenergic-specific DBH promoter activity. In this report, we demonstrate that three additional protein-binding sites (i.e., domains I, II, and III) between domain IV and the TATA box are critical for intact DBH promoter activity in noradrenergic cells and that they activate DBH transcription in a highly concerted manner. Transient transfection assays of mutant DBH reporter constructs indicated that domain I was active in every cell line tested, whereas domain III was preferentially active in DBH-positive cells. Remarkably, mutation of domain II was associated with inactivation of DBH promoter activity exclusively in DBH-positive cell lines, defining it as another noradrenergic-specific promoter element. The cell-specific profile of the promoter function of these sequence motifs was further supported byin vitro DNA-binding studies and Southwestern analysis. Furthermore, competition and antibody supershift assays show that transcription factors Sp1 and AP2 are the cognate nuclear factors interacting with domains I and III, respectively. Parallel evidence indicates that domain II is another Phox2a-binding site, demonstrating at least two binding sites for this factor in the upstream DBH promoter. Strikingly, four tandem copies of domain II increased the promoter activity of a minimal DBH promoter by 100- to 200-fold in DBH-positive cell lines without compromising cell specificity. Cotransfection of Phox2a-expression vector dramatically increased the activity of the multiple domain II promoter only in DBH-negative cell lines, confirming that domain II is responsive to Phox2a. Collectively, this study emphasizes a critical role of Phox2a as well as its functional synergism with other transcription factors (e.g., CREB, AP2, and Sp1) in transcriptional activation of the DBH gene.
Understanding the Impact of Physical Functioning on the Experience, Desire, and Satisfaction of Physical, Emotional and Social Intimacies in Persons with Amyotrophic Lateral Sclerosis (ALS)

The understanding of intimate relationships in persons with amyotrophic lateral sclerosis (ALS) is not yet understood. A review of the current literature, including an overview of ALS and the development and maintenance of intimate relationships using psychological theory, is included. Comparisons to multiple sclerosis, acquired physical disability, and older adults are included to gain a greater understanding of how changes in physical functioning may impact an intimate relationship. This study used archival data, in which participants completed the following measures: ALS Functional Rating Scale– Revised, Personal Assessment of Intimacy in Relationships, and ALS Specific Quality of Life Measurement–Revised. Results suggest high levels of intimacy and that gender, age, time since symptom onset, and physical and bulbar functional ability are not predictors for experience of, desire for, and satisfaction with intimate relationships. Couples appeared to be resilient, and intimacy was maintained regardless of physical functioning. Potential explanations, limitations of the study, and implications of the research are also
Clinical Epidemiology Dovepress Open Access to Scientific and Medical Research Open Access Full Text Article Dovepress Improving Reporting of Adverse Drug Reactions: Systematic Review

Background: Adverse drug reactions (ADRs) are a significant cause of morbidity and mortality, with many being identified post-marketing. Improvement in current ADR reporting, including utility of underused or innovative methods, is crucial to improve patient safety and public health. Objectives: To evaluate methods to improve ADR reporting via a systematic literature review. health searches on ADR reporting (January 1997 to August 2007) including cross-referenced articles. Twenty-four out of 260 eligible studies were identified and critically assessed. Studies were grouped as follows: i) spontaneous reporting (11); ii) medical chart/note review (2); iii) patient interviews/questionnaires (3); and iv) combination methods including computer-assisted methods (8). Results: Using computerized monitoring systems (CMS) to generate signals associated with changes in laboratory results with other methods can improve ADR reporting. Educational interventions combined with reminders and/or prescription card reports can improve hospital-based ADR reporting, and showed short to medium term improvement. Conclusions: The use of electronic health data combined with other methods for ADR reporting can improve efficiency and accuracy for detecting ADRs and can be extended to other health care settings. Although methods with educational intervention appear to be effective, few studies have reviewed long-term effects to assess if the improvements can be sustained.
Combined data-driven and event-driven scheduling technique for fast distributed cosimulation

Fast distributed cosimulation is a challenging problem for embedded system design. The main theme of this paper is to increase the simulation speed by reducing the frequency of intersimulator communications, reducing the active duration of simulators, and utilizing the parallelism of component simulators. Those enhancements are accomplished by a proposed virtual synchronization technique, which combines event-driven and data-driven simulation methods. Experimental results show that the proposed technique can boost the cosimulation speed significantly compared with previous conservative approaches.
Visuospatial Function in Alzheimer's Disease and Related Disorders

Over a century ago, Alois Alzheimer published a case description of a 51 year old woman whose initial behavioral abnormality was pathological jealousy of her husband. Her condition rapidly deteriorated with the accumulation of behavioral symptoms that constitute the syndrome of dementia. Besides memory loss, personality change, and agnosia, the woman described in the report exhibited visuospatial symptoms including perceptual abnormalities and dysfunction of spatial localization:
The Educational Experiences of Students with Asperger Syndrome

The Ministry of Education’s policy, Special Education 2000 (SE 2000) was intended to promote a model that ensured all students received an education that involved successful experiences (Ministry of Education, 1996). Students with Asperger Syndrome (AS) often have difficulty adapting to and achieving these successful experiences in their educational environment. This paper summarises the findings from a research project that was designed to investigate the issues that arise for students with AS, determine whether or not these experiences are generally positive or negative, and examine to what extent teachers have knowledge of AS. Data was gathered from interviews with three students, their parents and their teachers and a survey to examine teacher knowledge. Data was also gathered from nine interviews and twenty-nine questionnaires. This paper reports on the data gathered from the interviews. The emerging issues were: Difficulties accessing the curriculum, social difficulties, misunderstanding of parents’ roles, teacher responsibility, bullying, lack of teacher aide support, placement difficulties and sensory and environmental factors. The study concluded that the educational experience of the students was generally negative. The level of teacher knowledge was low, although the majority of teachers expressed an interest in gaining further knowledge.
Thiols are Main Determinants of Total Antioxidant Capacity of Cellular Homogenates

While the total antioxidant capacity (TAC) of blood plasma is mainly accounted for by urate, TAC of cell interior can be expected to depend more on other antioxidants, especially glutathione and protein -SH groups. We studied TAC of homogenates of several lines of cultured cells subjected to the action of thiol-modifying agents. Comparison of changes of TAC of the homogenates and of the level of total thiols (determined with a biradical spin label) demonstrates that alterations in cellular thiol content is the main determinant of changes of TAC of cell homogenates. These results show that estimation of TAC of cell extracts may be a useful parameter of assessment of oxidative stress, primarily of oxidation of thiol groups, yielding information different than TAC of body fluids.
Comparison of ambient solvent extraction methods for the analysis of fatty acids in non-starch lipids of flour and starch

BACKGROUND Lipids are minor components of flours, but are major determinants of baking properties and end-product quality. To the best of our knowledge, there is no single solvent system currently known that efficiently extracts all non-starch lipids from all flours without the risk of chemical, mechanical or thermal damage. This paper compares nine ambient solvent systems (monophasic and biphasic) with varying polarities: Bligh and Dyer (BD); modified Bligh and Dyer using HCl (BDHCL); modified BD using NaCl (BDNaCl); methanol–chloroform–hexane (3:2:1, v/v); Hara and Radin (hexane–isopropanol, 3:2, v/v); water-saturated n-butanol; chloroform; methanol and hexane for their ability to extract total non-starch lipids (separated by lipid classes) from wheat flour (Triticum aestivum L.). Seven ambient extraction protocols were further compared for their ability to extract total non-starch lipids from three alternative samples: barley flour (Hordeum vulgare L.), maize starch (Zea mays L.) and tapioca starch (Manihot esculenta Crantz). RESULTS For wheat flour the original BD method and those containing HCl or NaCl tended to extract the maximum lipid and a significant correlation between lipid extraction yield (especially the glycolipids and phospholipids) and the polarity of the solvent was observed. For the wider range of samples BD and BD HCl repeatedly offered the maximum extraction yield and using pooled standardized (by sample) data from all flours, total non-starch lipid extraction yield was positively correlated with solvent polarity (r = 0.5682, P < 0.05) and water ratio in the solvent mixture (r = 0.5299, P < 0.05). CONCLUSION In general, BD-based methods showed better extraction yields compared to methods without the addition of water and, most interestingly, there was much greater method dependence of lipid yields in the starches when compared to the flour samples, which is due to the differences in lipid profiles between the two sample types (flours and starches).