Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychological health of retirees in rural Scotland

A concise and factual abstract is required (not exceeding 200 words). This should be typed on a separate page following the title page. The abstract should state briefly the purpose of the research, the principal results and major conclusions. An abstract is often presented separate from the article, so it must be able to stand alone. References should therefore be avoided, but if essential, they must be cited in full, without reference to the reference list. Graphical abstract A Graphical abstract is optional and should summarize the contents of the article in a concise, pictorial form designed to capture the attention of a wide readership online. Authors must provide images that clearly represent the work described in the article. Graphical abstracts should be submitted as a separate file in the online submission system. Image size: Please provide an image with a minimum of 531 × 1328 pixels (h × w) or proportionally more. The image should be readable at a size of 5 × 13 cm using a regular screen resolution of 96 dpi. Preferred file types: TIFF, EPS, PDF or MS Office files. See http://www.elsevier. com/graphicalabstracts for examples. Authors can make use of Elsevier's Illustration and Enhancement service to ensure the best presentation of their images also in accordance with all technical requirements: Illustration Service. Highlights Highlights are mandatory for this journal. They consist of a short collection of bullet points that convey the core findings of the article and should be submitted in a separate file in the online submission system. Please use 'Highlights' in the file name and include 3 to 5 bullet points (maximum 85 characters, including spaces, per bullet point). See http://www.elsevier. com/highlights for examples. Keywords Immediately after the abstract, provide a maximum of 6 keywords, using American spelling and avoiding general and plural terms and multiple concepts (avoid, for example, 'and', 'of'). Be sparing with abbreviations: only abbreviations firmly established in the field may be eligible. These keywords will be used for indexing purposes. Abbreviations Define abbreviations that are not standard in this field in a footnote to be placed on the first page of the article. Such abbreviations that are unavoidable in the abstract must be defined at their first mention there, as well as in the footnote. Ensure consistency of abbreviations throughout the article. AUTHOR INFORMATION PACK 30 May 2012 www.elsevier. com/locate/clinpsychrev 6
A study of lexicogrammatical and discourse strategies for 'suggestion' with the use of the English speech act corpus

347 Abstract This paper endeavours to sketch out linguistic strategies to perform an English speech act of ‘suggesting’ through analyses of responses provided by U.S. university undergraduate students. The study foci are on linguistic strategies at the (1) lexical, (2) grammatical, and (3) discourse (i.e. conversation) levels. The results of this study demonstrate (i) the effectiveness of the English speech act corpora for the ELT (English Language Teaching) pursuing the CLT (Communicative Language Teaching) in providing both instructors and learners with ‘natural’ and ‘appropriate’ expressions in particular contexts; (ii) lexical features and discourse strategies (i.e. semantic formulae) of the target speech act ‘suggestion’, performed by native English speakers.
Game Theory based Defense Strategy against Denial of Service Attack using Puzzles

Security issues have become a major issue in recent years due to the advancement of technology in networking and its use in a destructive way. A number of defense strategies have been devised to overcome the flooding attack which is prominent in the networking industry due to which depletion of resources takes place. But these mechanism are not designed in an optimally and effectively and some of the issues have been unresolved. Hence in this paper we suggest a Game theory based strategy to create a series of defence mechanisms using puzzles. Here the concept of Nash equilibrium is used to handle sophisticated flooding attack to defend distributed attacks from unknown
Three-year surveillance of community-acquired Staphylococcus aureus infections in children.

BACKGROUND Methicillin-resistant Staphylococcus aureus (MRSA) isolates are increasingly frequent causes of skin and soft-tissue infections or invasive infections in many communities. METHODS Prospective surveillance for community-acquired S. aureus infections at Texas Children's Hospital was initiated on 1 August 2001. Infections meeting the definition of community-acquired were identified. Demographic and clinical data were collected. Antibiotic susceptibilities, including inducible resistance to macrolide, lincosamide, and streptogramin B (MLSB), were determined in the clinical microbiology laboratory with the methodology of the NCCLS. All data were entered into a computer database. Data were analyzed by chi2 tests. RESULTS From 1 August 2001 to 31 July 2004, the percentage of community-acquired S. aureus isolates that were methicillin resistant increased from 71.5% (551 of 771 isolates) in year 1 to 76.4% (1193 of 1562 isolates) in year 3 (P = .008). The number of both community-acquired MRSA (CA-MSRA) isolates and community-acquired methicillin-susceptible S. aureus (CA-MSSA) isolates increased yearly, but the rate of increase was greater for the CA-MRSA isolates. Among the CA-MRSA isolates, 2542 (95.6%) were obtained from children with skin and soft-tissue infections, and 117 (4.4%) were obtained from children with invasive infections. Overall, 62% of children with CA-MRSA isolates and 53% of children with CA-MSSA isolates were admitted to the hospital (P = .0001). The rate of clindamycin resistance increased significantly for both CA-MRSA isolates (P = .003) and CA-MSSA isolates (P = .00003) over the 3 years. MLSB inducible resistance was found in 27 (44%) of 62 clindamycin-resistant CA-MSSA isolates, compared with 6 (4.5%) of 132 clindamycin-resistant CA-MRSA isolates (P < .000001). CONCLUSIONS CA-MRSA isolates account for an increasing percentage and number of infections at Texas Children's Hospital. Clindamycin resistance increased among community-acquired S. aureus isolates. Community surveillance of community-acquired S. aureus infections is critical to determine the appropriate empiric antibiotic treatment for either local or invasive infections.
Distribution of the Number of Encryptions in Revocation Schemes for Stateless Receivers

We study the number of encryptions necessary to revoke a set of users in the complete subtree scheme (CST) and the subset-difference scheme (SD). These are well-known tree based broadcast encryption schemes. Park and Blake in: Journal of Discrete Algorithms, vol. 4, 2006, pp. 215―238, give the mean number of encryptions for these schemes. We continue their analysis and show that the limiting distribution of the number of encryptions for these schemes is normal. This implies that the mean numbers of Park and Blake are good estimates for the number of necessary encryptions used by these schemes.
Gene Maps of Nonhuman Primates.

Comparative gene mapping of mammals has progressed rapidly since the late 1980s. Much is known about the comparative structure and organization of the human, murine, feline, and bovine genomes, among others. A substantial amount of information has also been generated concerning the gene maps of primates. Nonhuman primates are, of course, the closest evolutionary relatives of humans; and as a result, an understanding of the genetics of these species is critical for addressing questions in both biomedical research and evolutionary biology. However, the available information concerning the comparative maps of nonhuman primates is narrowly focused, in the sense that only a few species have received significant attention. The data are also comparatively thin. Even in the most extensively analyzed species, relatively few functional genes have been assigned to specific chromosomal locations. In addition, the data are quite inconsistent, with different genes mapped in different primate species, making genome-wide comparisons difficult. Nevertheless, a significant amount of information is available, and the rate of progress is likely to increase.
Comparative studies of the antigenic polypeptide species VP4, VP6, and VP7 of three strains of bovine rotavirus

Three bovine rotavirus strains belonging to two distinct serotype groups, serotype 6 (NCDV and B641) and B223, distinct from the other six mammalian rotavirus serotypes but not yet assigned to a serotype group, were compared with each other and with canine rotavirus (K9, serotype 3) by studying the properties of their cognate polypeptide species VP4, VP6, and VP7. The three viruses showed distinct differences in the polyacrylamide gel electrophoretic migration rates of protein species VP4 and VP7, with minor differences in VP6. Differences were also observed among the migration patterns of genome segments 4, 6, and the 7-8-9 triplet, which encode VP4, VP6, and VP7, respectively. Monoclonal antibodies (MAbs) to B223, which were directed against VP4 or VP7, showed homologous specificity for neutralization and immunofluorescence (IF), although one MAb reactive with VP4 also reacted by IF and by immunoprecipitation (IP) with all four viruses and weakly neutralized B641 and K9. This MAb may react with the epitope responsible for the B223-induced one-way neutralizing and protection response of calves against B641 observed in earlier studies. MAbs reactive with VP6 by IP showed enzyme-linked immunosorbent assay and IF reactivity with all three bovine viruses and the canine virus. The two serotype 6 viruses could be distinguished by the two B641 MAbs, B641-N2b reacting by neutralization and IF with both viruses and B641-N1 reacting with B641 and the serotype 3 canine rotavirus but not with NCDV. One nonneutralizing B641 MAb reacted by IP and IF with VP7 of all four rotaviruses examined, and one B223 MAb neutralized B223 and, to low titer, B641 and K9 although reacting by IP and IF with all four viruses. Three MAb-resistant mutants were selected by passage of B223 in the presence of one of three selected B223 MAbs at concentrations which only neutralized approximately 90% of the infectious virions. The resulting mutants were 100% resistant to neutralization with their respective MAb but remained neutralizable by the same selection of MAbs as the parent B223 virus.
A fully complementary and fully differential self-biased asynchronous CMOS comparator

This paper presents a novel CMOS asynchronous voltage comparator topology composed of a preamplifier cascaded by the positive feedback latch. The proposed circuit is fully differential and possesses desired properties like purely capacitive input impedance with rail-to-rail output swing, low noise and offset, etc. Furthermore, the comparator is also completely self-biased embedding the negative feedback in the biasing loop which makes it highly resistant to process, supply voltage and temperature variations. The design and optimization methodologies are discussed as well. Since the comparator delivers high operating speeds under relatively low power consumption, it is suitable for use in tomorrow's SoC data transceivers and converters.
Multicriteria decision-making in railway route planning and design

The route selection methodology, based on multicriteria decision-making and applied in railway route planning and design, is presented in the paper. The proposed methodology enables an integrated and systematic resolution of this problem, and it results in the most favourable route proposal based on predefined criteria and real-life constraints. The technology is based on the compromise ranking method (VIKOR), and it has been checked during selection of one out of four railway route alternatives on the Corridor X, between Inđija and Novi Sad train stations.
Safety Assessment of Dimethiconol and Its Esters and Reaction Products as Used in Cosmetics

Dimethiconol and its esters and reaction products are used in cosmetics as either skin-conditioning agents or hair-conditioning agents. The Cosmetic Ingredient Review (CIR) Expert Panel reviewed relevant data and concluded that these ingredients are safe in the present practices of use and concentration described in this safety assessment. While there is an absence of data on reproductive and developmental toxicity and limited tumorigenicity and toxicokinetics data, the Panel reasoned that these ingredients would not be absorbed through the skin, obviating concern over potential reproductive and developmental toxicity or carcinogenicity.
The Effect of Haptic Degrees of Freedom on Task Performance in Virtual Surgical Environments

Force and touch feedback, or haptics, can play a significant role in the realism of virtual reality surgical simulation. While it is accepted that simulators providing haptic feedback often outperform those that do not, little is known about the degree of haptic fidelity required to achieve simulation objectives. This article evaluates the effect that employing haptic rendering with different degrees of freedom (DOF) has on task performance in a virtual environment. Results show that 6-DOF haptic rendering significantly improves task performance over 3-DOF haptic rendering, even if computed torques are not displayed to the user. No significant difference could be observed between under-actuated (force only) and fully-actuated 6-DOF feedback in two surgically-motivated tasks.
Evaluation of Off-label Prescribing at a Children's Rehabilitation Center.

OBJECTIVE This study was developed to evaluate the incidence of off-label prescribing at a pediatric rehabilitation center. Secondary objectives were to describe the medications, patient age groups, and diagnoses most often associated with off-label prescribing. METHODS This was a prospective observational study conducted at an academic, inpatient children's rehabilitation center from November 11, 2011, to April 1, 2012. Patients younger than 16 years of age who received at least 1 prescription medication were included. Data were collected from the patients' electronic medical records. RESULTS A total of 240 medications orders were placed during the study, with 57% written off-label. Thirty-five patients (88%) received at least 1 off-label medication. Forty-nine percent of the orders were for patients younger than the approved range, with 48% written for an unapproved indication, 2% for an alternative route of administration, and 1% for an unapproved age and indication. Children 2 to 12 years of age received 40% of the off-label orders, followed by adolescents with 37%. The therapeutic classes most often prescribed off-label were central nervous system agents and anti-infectives. CONCLUSION Off-label prescribing was found in the majority of children receiving rehabilitative services, a rate as high or higher than that reported in pediatric acute care or clinic settings. The medications prescribed off-label most often were central nervous system agents, reflecting the need to study medications in the chronic rehabilitation population to optimize function in children with brain or spinal cord injury.
Gamma Tocopherol and Lovastatin Additively Induced Apoptosis in Human Colorectal Carcinoma Cell Line (HT29)

Background Programmed cell death (apoptosis) is a physiological process needed to remove unwanted or damaged cells. It has been hypothesized that any failure of programmed cell death leads to the development of neoplasm. Identifying new agents which induce apoptosis in tumor cells is of great significance in treatment of neoplasms. Numerous studies suggest that exposure of tumor cells to statins and gamma tocopherol can lead to cell death. Objectives The aim of this study was to evaluate the cell death induced by gamma tocopherol and lovastatin in human colorectal carcinoma cell line (HT29) using flow cytometry. Material and Methods HT29 cells were grown in DMEM medium, exposed to different concentrations of lovastatin (10,20,40,100μM ) and gamma tocopherol (25,50,100,200μM) for 48 and 72 hours, individually and in combination (100μM both, 48 h). Phenotype of apoptosis was determined by means of flow cytometry. Results All Concentrations of lovastatin (10, 20, 40, 100 μM) and gamma tocopherol (25, 50, 100, 200 μM) induced an apoptotic response in HT29 cells. In combination, a significant increase in apoptosis phenotype was also demonstrated (P < 0.05). Conclusions This study showed that lovastatin when combined with gamma tocopherol, could induce apoptosis in HT29 cells more potently than each agent alone, which uncovers the significance of targeting the proliferative signaling in different points of the pathway.
Learning of soccer player agents using a policy gradient method: Coordination between kicker and receiver during free kicks

The RoboCup Simulation League is recognized as a test bed for research on multi-agent learning. As an example of multi-agent learning in a soccer game, we dealt with a learning problem between a kicker and a receiver when a direct free kick is awarded just outside the opponentpsilas penalty area. In such a situation, to which point should the kicker kick the ball? We propose a function that expresses heuristics to evaluate an advantageous target point for safely sending/receiving a pass and scoring. The heuristics includes an interaction term between a kicker and a receiver to intensify their coordination. To calculate the interaction term, we let kicker/receiver agents have a receiver/kicker action decision model to predict his teammatepsilas action. The evaluation function makes it possible to handle a large space of states consisting of the positions of a kicker, a receiver, and their opponents. The target point of the free kick is selected by the kicker using Boltzmann selection with an evaluation function. Parameters in the function can be learned by a kind of reinforcement learning called the policy gradient method. The point to which a receiver should run to receive the ball is simultaneously learned in the same manner. The effectiveness of our solution was shown by experiments.
Mechanisms of Aortic and Cardiac Dysfunction in Uremic Mice With Aortic Calcification

Background— Chronic renal failure (CRF) is associated with cardiac dysfunction and increased aortic stiffness. The mechanisms involved are not clearly understood. We examined changes over time in cardiac and aortic function in a murine CRF model. Methods and Results— Eight-week-old mice were randomly assigned to 1 of 4 groups: wild-type non-CRF, wild-type CRF, apolipoprotein E knockout non-CRF, and apolipoprotein E knockout CRF. Echocardiography was performed and blood samples were taken at baseline and after 6 and 10 weeks of CRF. Vascular reactivity and adhesion molecule expression were studied after 6 and 10 weeks of CRF. Left ventricular hypertrophy, altered left ventricular relaxation, and increased aortic stiffness were observed after 6 weeks of CRF and persisted after 10 weeks. The 4 groups of mice did not significantly differ in terms of arterial blood pressure and aortic structure. The degree of vascular calcification and serum total cholesterol concentration were higher in the CRF groups than in the non-CRF groups. These changes, however, could not explain the cardiac and vascular differences seen in the 2 CRF groups. In contrast, alterations in vascular reactivity, the upregulation of adhesion molecule expression, and CRF status were significantly associated with these changes. Conclusions— In a mouse model of CRF, left ventricular hypertrophy, cardiac diastolic dysfunction, and increased aortic stiffness were not related to structural changes in the aorta (including aortic calcification) or high serum cholesterol levels. However, cardiac and aortic abnormalities were associated with the extent of subendothelial dysfunction and the severity of CRF.
Abnormalities of thalamic activation and cognition in schizophrenia.

OBJECTIVE Functional and structural magnetic resonance imaging (MRI) was used to investigate relationships among structure, functional activation, and cognitive deficits related to the thalamus in individuals with schizophrenia and healthy comparison subjects. METHOD Thirty-six schizophrenia subjects and 28 healthy comparison subjects matched by age, gender, race, and parental socioeconomic status underwent structural and functional MRI while performing a series of memory tasks, including an N-back task (working memory), intentional memorization of a series of pictures or words (episodic encoding), and a yes/no recognition task. Functional activation magnitudes in seven regions of interest within the thalamic complex, as defined by anatomical and functional criteria, were computed for each group. RESULTS Participants with schizophrenia exhibited decreased activation within the whole thalamus, the anterior nuclei, and the medial dorsal nucleus. These nuclei overlap with subregions of the thalamic surface that the authors previously reported to exhibit morphological abnormalities in schizophrenia. However, there were no significant correlations between specific dimensions of thalamic shape variation (i.e., eigenvectors) and the activation patterns within thalamic regions of interest. Better performance on the working memory task among individuals with schizophrenia was significantly associated with increased activation in the anterior nuclei, the centromedian nucleus, the pulvinar, and the ventrolateral nuclei. CONCLUSIONS These results suggest that there are limited relationships between morphological and functional abnormalities of the thalamus in schizophrenia subjects and highlight the importance of investigating relationships between brain structure and function.
Occupational asthma and allergy in snow crab processing in Newfoundland and Labrador

Background: Risk factors and prevalence of occupational asthma (OA) and occupational allergy (OAl) in the snow crab-processing industry have been poorly studied. Objective: To estimate the prevalence of OA and OAl in snow crab-processing workers and determine their relationship with exposure to snow crab allergens and other potential risk factors. Methods: A total of 215 workers (120 female/95 male) were recruited from four plants in Newfoundland and Labrador, Canada in 2001–2002. Results from questionnaires, skin-prick tests to snow crab meat and cooking water, specific IgEs against the latter, spirometry and peak flow monitoring were used to develop a diagnostic algorithm. An index based on work history and exposure measurements of snow crab aeroallergens was developed to estimate the cumulative exposure for each worker. Results: The prevalences of almost certain or highly probable OA and OAl were 15.8% and 14.9%, respectively. A high cumulative exposure to crab allergens, in jobs mostly held by women, was associated with OA (odds ratio (OR) = 14.0, 95% CI 3.0 to 65.8) (highest vs lowest Cumulative Exposure Index) and with OAl (OR = 7.1, 95% CI 1.9 to 29.0); job held when symptoms started (cleaning, packing, freezing) also predicted OA (OR = 3.9, 95% CI 1.6 to 8.7) and OAl (OR = 3.2, 95% CI 1.4 to 7.5). Atopy (OR = 2.8, 95% CI 1.2 to 6.8), female gender (OR = 10.7, 95% CI 3.6 to 32.1) and smoking were significant determinants for OA (OR = 3.1, 95% CI 1.3 to 7.4). Conclusions: The prevalences of OA and OAl are high in snow crab-processing workers of Canada’s East Coast. Cumulative exposure to snow crab allergens was related to the prevalences of OA and OAl in a dose–response manner taking into account atopy, gender and smoking.