Miracle-dz/UniFAR-FTUs huggingface dataset:
Taxonomy of Fusarium genus: A continuous fight between lumpers and splitters

The genus Fusarium comprises a high number of fungal species that can be plant-pathogenic, causing diseases in several agriculturally important crops including cereals, and also can be harmful for humans and animals since many of them are toxigenic. The identification of mycotoxigenic Fusarium species still remains a most critical issue, given that the number of species recognized in the genus has been constantly changing in the last century in accordance with the different taxonomic systems. Together with the morphological identification, current criteria for Fusarium species identification are also based on biological and phylogenetic species recognition. However these criteria rarely agree to each other. Therefore, it is still a charming scientific challenge to ascertain the taxonomic status of Fusarium species, which in the years have been continuously 'splitted' and 'lumpered' by scientists. The major cases of the taxonomic debates amongst the Fusarium community will be here discussed.
A cognitive stressor for event-related potential studies: the Portland arithmetic stress task

Abstract In this experiment, we developed and evaluated the Portland Arithmetic Stress Task (PAST) as a cognitive stressor to evaluate acute and sustained stress reactivity for event-related potential (ERP) studies. The PAST is a titrated arithmetic task adapted from the Montreal Imaging Stress Task (MIST), with added experimental control over presentation parameters, improved and synchronized acoustic feedback and generation of timing markers needed for physiological analyzes of real-time brain activity. Thirty-one older adults (M = 60 years) completed the PAST. EEG was recorded to assess feedback-related negativity (FRN) and the magnitude of the stress response through autonomic nervous system activity and salivary cortisol. Physiological measures other than EEG included heart rate, respiration rate, heart rate variability, blood pressure and salivary cortisol. These measures were collected at several time points throughout the task. Feedback-related negativity evoked-potential responses were elicited and they significantly differed depending on whether positive or negative feedback was received. The PAST also increased systolic blood pressure, heart rate variability and respiration rates compared to a control condition attentional task. These preliminary results suggest that the PAST is an effective cognitive stressor. Successful measurement of the feedback-related negativity suggests that the PAST is conducive to EEG and time-sensitive ERP experiments. Moreover, the physiological findings support the PAST as a potent method for inducing stress in older adult participants. Further research is needed to confirm these results, but the PAST shows promise as a tool for cognitive stress induction for time-locked event-related potential experiments.
Involvement of B Cells, Immunoglobulins, and Syk in the Pathogenesis of Abdominal Aortic Aneurysm

Background Abdominal aortic aneurysm (AAA) is a potentially life‐threatening disease that is common in older individuals. Currently, therapeutic options are limited to surgical interventions. Although it has long been known that AAA tissue is enriched in B cells and immunoglobulins, their involvement in AAA pathogenesis remains controversial. Methods and Results We investigated the role of B cells and immunoglobulins in a murine model of AAA, induced with a periaortic application of CaCl2, and in human AAA. Both human and mouse AAA tissue showed B‐cell infiltration. Mouse AAA tissue showed deposition of IgG and activation of Syk, a key molecule in B‐cell activation and immunoglobulin function, which were localized to infiltrating cells including B cells and macrophages. B‐cell–deficient muMT mice showed suppression of AAA development that was associated with reduced activation of Syk and less expression of matrix metalloproteinase‐9. Administration of exogenous immunoglobulins restored the blunted Syk activation and AAA development in muMT mice. Additionally, exogenous immunoglobulins induced interleukin‐6 and metalloproteinase‐9 secretions in human AAA tissue cultures. Furthermore, administration of R788, a specific Syk inhibitor, suppressed AAA expansion, reduced inflammatory response, and reduced immunoglobulin deposition in AAA tissue. Conclusions From these results, we concluded that B cells and immunoglobulins participated in AAA pathogenesis by promoting inflammatory and tissue‐destructive activities. Finally, we identified Syk as a potential therapeutic target.
Evaluating the Usability and Usefulness of a Mobile App for Atrial Fibrillation Using Qualitative Methods: Exploratory Pilot Study

Background Atrial fibrillation (AFib) is the most common form of heart arrhythmia and a potent risk factor for stroke. Nonvitamin K antagonist oral anticoagulants (NOACs) are routinely prescribed to manage AFib stroke risk; however, nonadherence to treatment is a concern. Additional tools that support self-care and medication adherence may benefit patients with AFib. Objective The aim of this study was to evaluate the perceived usability and usefulness of a mobile app designed to support self-care and treatment adherence for AFib patients who are prescribed NOACs. Methods A mobile app to support AFib patients was previously developed based on early stage interview and usability test data from clinicians and patients. An exploratory pilot study consisting of naturalistic app use, surveys, and semistructured interviews was then conducted to examine patients’ perceptions and everyday use of the app. Results A total of 12 individuals with an existing diagnosis of nonvalvular AFib completed the 4-week study. The average age of participants was 59 years. All participants somewhat or strongly agreed that the app was easy to use, and 92% (11/12) reported being satisfied or very satisfied with the app. Participant feedback identified changes that may improve app usability and usefulness for patients with AFib. Areas of usability improvement were organized by three themes: app navigation, clarity of app instructions and design intent, and software bugs. Perceptions of app usefulness were grouped by three key variables: core needs of the patient segment, patient workflow while managing AFib, and the app’s ability to support the patient’s evolving needs. Conclusions The results of this study suggest that mobile tools that target self-care and treatment adherence may be helpful to AFib patients, particularly those who are newly diagnosed. Additionally, participant feedback provided insight into the varied needs and health experiences of AFib patients, which may improve the design and targeting of the intervention. Pilot studies that qualitatively examine patient perceptions of usability and usefulness are a valuable and often underutilized method for assessing the real-world acceptability of an intervention. Additional research evaluating the AFib Connect mobile app over a longer period, and including a larger, more diverse sample of AFib patients, will be helpful for understanding whether the app is perceived more broadly to be useful and effective in supporting patient self-care and medication adherence.
Increased susceptibility to colitis and colorectal tumors in mice lacking core 3–derived O-glycans

Altered intestinal O-glycan expression has been observed in patients with ulcerative colitis and colorectal cancer, but the role of this alteration in the etiology of these diseases is unknown. O-glycans in mucin core proteins are the predominant components of the intestinal mucus, which comprises part of the intestinal mucosal barrier. Core 3–derived O-glycans, which are one of the major types of O-glycans, are primarily expressed in the colon. To investigate the biological function of core 3–derived O-glycans, we engineered mice lacking core 3 β1,3-N-acetylglucosaminyltransferase (C3GnT), an enzyme predicted to be important in the synthesis of core 3–derived O-glycans. Disruption of the C3GnT gene eliminated core 3–derived O-glycans. C3GnT-deficient mice displayed a discrete, colon-specific reduction in Muc2 protein and increased permeability of the intestinal barrier. Moreover, these mice were highly susceptible to experimental triggers of colitis and colorectal adenocarcinoma. These data reveal a requirement for core 3–derived O-glycans in resistance to colonic disease.
Determinants of Bacteriophage 933W Repressor DNA Binding Specificity

We reported previously that 933W repressor apparently does not cooperatively bind to adjacent sites on DNA and that the relative affinities of 933W repressor for its operators differ significantly from that of any other lambdoid bacteriophage. These findings indicate that the operational details of the lysis-lysogeny switch of bacteriophage 933W are unique among lambdoid bacteriophages. Since the functioning of the lysis-lysogeny switch in 933W bacteriophage uniquely and solely depends on the order of preference of 933W repressor for its operators, we examined the details of how 933W repressor recognizes its DNA sites. To identify the specificity determinants, we first created a molecular model of the 933W repressor-DNA complex and tested the predicted protein-DNA interactions. These results of these studies provide a picture of how 933W repressor recognizes its DNA sites. We also show that, opposite of what is normally observed for lambdoid phages, 933W operator sequences have evolved in such a way that the presence of the most commonly found base sequences at particular operator positions serves to decrease, rather than increase, the affinity of the protein for the site. This finding cautions against assuming that a consensus sequence derived from sequence analysis defines the optimal, highest affinity DNA binding site for a protein.
Structure and dynamics of the actin filament.

The structures of filamentous Mg-ATP-actin (F actin) in the presence and absence of KCl have been mapped with hydroxyl radicals (*OH) generated by synchrotron X-ray radiolysis. Proteolysis and mass spectrometry (MS) analysis revealed 52 reactive side-chain sites from 27 distinct peptides within actin. The reactivities of these probe sites with *OH in the F-actin states are compared with those of Mg-ATP-G-actin (monomers) analyzed previously [Guan, J.-Q. et al. (2003) Biochemistry 42, 11992-12000]. Filament-dependent protection within subdomains 2, 3, and 4 and at the C terminus is consistent with longitudinal contacts of monomers within the filament helical structure as predicted by the Holmes model. In the absence of KCl, the extent of filament-dependent protection rarely reached 3-fold, consistent with a highly dynamic filament characterized by relatively weak interactions between actin protomers. However, in the presence of KCl, the extents of protection are significantly increased, consistent with a well-ordered, more tightly packed filament structure. Filament-dependent enhancements of reactivity not predicted by the Holmes model are seen for a peptide that overlaps the "hydrophobic plug" (H-plug) region and for a peptide that forms contacts with the polyphosphate moiety of the bound nucleotide. Overall, these data are both consistent with and complementary to a recent deuterium-exchange MS study of filamentous actin [Chik, J. K. , and Schriemer, D.C. (2003) J. Mol. Biol. 334, 373-385], which also did not detect any burial of the H plug upon formation of filaments.
Review: An approach of Utilizing Low Cost By-products

This basic study discuss about the potential utilization of farming waste based bio-sorbents for evacuating substantial metals. Various agricultural wastes such as peanut shells, banana peels, sugarcane bagasse, rice husk, coconut husk, oil palm shell can be useful. Sorption limits of agricultural wastes were altogether influenced by arrangement of pH, adsorbent mass and contact time. Treatment of these metals with agricultural wastes decreased their dangerous consequences for P. aeruginosa. This study has demonstrated that agricultural wastes could be utilized as ease options in wastewater treatment for the expulsion of substantial metals.
Effect of Scaling and Root Planning in Periodontitis on Peripheral Blood

Numerous studies linking periodontitis and cardiovascular disease have been observed. We used a treatment intervention model to study the relationship between periodontitis and peripheral blood. We studied 37 subjects (M:F, 16:21, in age group 23-40 years) with severely periodontitis requiring scaling and root planning. Blood samples were obtained: (1) at initial presentation, (2) after 3 weeks of scaling and root planning (3) after 10 weeks of scaling and root planning. After the treatment, there is significant decrease in white blood cells, neurophil, platelets, while increase hemoglobin and RBC levels. This research paper shows that elimination of periodontitis by scaling and root planning reduces systemic inflammatory markers of cardiovascular risk. It also supports that links between periodontitis and cardiovascular disease exist.
SRP-MS: A new routing protocol for delay tolerant Wireless Sensor Networks

Sink Mobility is becoming popular due to excellent load balancing between nodes and ultimately resulting in prolonged network lifetime and throughput. A major challenge is to provide reliable and energy-efficient operations are to be taken into consideration for different mobility patterns of sink. Aim of this paper is lifetime maximization of Delay Tolerant Wireless Sensor Networks (WSNs) through the manipulation of Mobile Sink (MS) on different trajectories. We propose Square Routing Protocol with MS (SRP-MS) based on existing SEP (Stable Election Protocol) by making it Cluster Less (CL) and introducing sink mobility.
Radiation Hardening by the Modification of Shallow Trench Isolation Process in Partially Depleted SOI MOSFETs

Two radiation hardening processes for shallow trench isolation (STI), i.e., Si+ implantation and STI oxide nitridation are investigated, including the impact on nominal electrical characteristics and radiation hardness. The total ionizing dose effects of the nMOS devices are proved to be sensitive to the STI radiation hardening process conditions. There are optimum process conditions to achieve the best effectiveness of radiation hardening. Then, a 130-nm radiation-hardened PDSOI technology has been developed. The radiation hardness is verified by static random access memories with small storage capacities.
Behavioral Plasticity and the Origins of Novelty: The Evolution of the Rattlesnake Rattle

Environmentally induced behavior (behavioral plasticity) has long been hypothesized to promote the origins of novel morphological traits, but this idea remains controversial. One context in which this hypothesis can be evaluated is animal communication, where behavior and morphology are often linked. Here, we examined the evolution of one of nature’s most spectacular communication signals: the rattlesnake rattle. We specifically evaluated whether rattlesnake rattling behavior—and, hence, the rattle—originated from a simple behavior: vibrating the tail when threatened. By reconstructing the ancestral state of defensive tail vibration, we show that this behavior is nearly ubiquitous in the Viperidae (the family that includes rattlesnakes) and widespread in the Colubridae (the largest snake family, nearly all of which are nonvenomous), suggesting a shared origin for the behavior between these families. After measuring tail vibration in 56 species of Viperidae and Colubridae, we show that the more closely related a species was to rattlesnakes, the more similar it was to rattlesnakes in duration and rate of tail vibration. Thus, the rattlesnake rattle might have evolved via elaboration of a simple behavior. These data thereby support the long-standing hypothesis that behavioral plasticity often precedes—and possibly instigates—the evolution of morphological novelty.
Who cares? Toward an integrated theory of volunteer work

The authors construct an integrated theory of formal and informal volunteer work based on the premises that volunteer work is (1) productive work that requires human capital, (2) collective behavior that requires social capital, and (3) ethically guided work that requires cultural capital. Using education, income and functional health to measure human capital, number of children in the household and informal social interaction to measure social capital, and religiosity to measure cultural capital, they estimate a model in which formal volunteering and informal helping are reciprocally related but connected in different ways to different forms of capital. Using two-wave data from the Americans' Changing Lives panel study, they find that formal volunteering is positively related to human capital, number of children in the household, informal social interaction and religiosity. Informal helping, such as helping a neighbor, is primarily determined by gender, age and health. Estimation of reciprocal effects reveals that formal volunteering has a positive effect on helping, but helping does not affect formal volunteering
Study on the Synthesized Black Low-Magnetism Diamond

Based on the testing of the magnetic susceptibility of the raw materials and the final products:graphite,Ni_(70)Mn_(25)Co_5,general diamond,black diamond and melting NiMnCoC in the synthesis of diamond and the analyzing of the fracture surface of black diamond and general diamond by the Scanning Electron Microscope,it is found that the magnetism of the synthetic diamond is caused by(NiMnCoC) inclusions.There are many inclusions in the fracture surface of general diamond,but there are no inclusions in the fracture surface of black diamond,merely many cavities existed.The low magnetism existing in black diamond is from the poor quality and more-cracked diamond caused by higher temperature and lower pressure in the synthesis of diamond.A lot of cracks exit between diamond surface and inclusion.Because the magnetic catalyst inclusions are removed by acids through the cracks during the process of chemical treatment,the black diamond has low magnetism.
Sympathetic nerve activity during prolonged rhythmic forearm exercise.

Exercise is a potent stimulus to activate the sympathetic nervous system. Previous work suggests that metabolite-sensitive muscle afferents are activated near the point of fatigue, and, when activated, they determine the muscle sympathetic nerve activity (MSNA) response to isometric forearm exercise. Yet, studies using a more prolonged rhythmic exercise paradigm suggest that the sympathetic nervous system can be activated in a more graded fashion. The purpose of this study was to determine whether metaboreceptor stimulation would also be responsible for MSNA responses to prolonged rhythmic isotonic forearm exercise. Subjects (n = 16) performed rhythmic isotonic forearm exercise at 25% maximal voluntary contraction for 30 min as we measured MSNA (microneurography). We observed progressive increases in MSNA with a peak increase of 161 units from a baseline value of 180 units. We also performed posthandgrip circulatory arrest (PHG-CA) in nine of these subjects. This maneuver isolates the metaboreceptor contribution to MSNA. During PHG-CA, delta MSNA values were not different from those observed during a freely perfused recovery period (n = 7). We also compared MSNA responses during the rhythmic paradigm with those seen during a static protocol at 40% of maximal voluntary contraction in five subjects. The two types of exercise caused similar increases in MSNA, but only the static paradigm was associated with a sustained MSNA response during PHG-CA. Finally, 31P-nuclear magnetic resonance was used to evaluate muscle metabolic responses during rhythmic and static forearm exercise (n = 6). Static exercise caused muscle acidosis and an increase in H2PO4-, whereas rhythmic exercise had no effect on muscle metabolism. (ABSTRACT TRUNCATED AT 250 WORDS)
Nonlinear and quantum optics with whispering gallery resonators

Optical whispering gallery modes (WGMs) derive their name from a famous acoustic phenomenon of guiding a wave by a curved boundary observed nearly a century ago. This phenomenon has a rather general nature, equally applicable to sound and all other waves. It enables resonators of unique properties attractive both in science and engineering. Very high quality factors of optical WGM resonators persisting in a wide wavelength range spanning from radio frequencies to ultraviolet light, their small mode volume, and tunable in- and out- coupling make them exceptionally efficient for nonlinear optical applications. Nonlinear optics facilitates interaction of photons with each other and with other physical systems, and is of prime importance in quantum optics. In this paper we review numerous applications of WGM resonators in nonlinear and quantum optics. We outline the current areas of interest, summarize progress, highlight difficulties, and discuss possible future development trends in these areas.
A robust and powerful two‐step testing procedure for local ancestry adjusted allelic association analysis in admixed populations

Genetic association studies in admixed populations allow us to gain deeper understanding of the genetic architecture of human diseases and traits. However, population stratification, complicated linkage disequilibrium (LD) patterns, and the complex interplay of allelic and ancestry effects on phenotypic traits pose challenges in such analyses. These issues may lead to detecting spurious associations and/or result in reduced statistical power. Fortunately, if handled appropriately, these same challenges provide unique opportunities for gene mapping. To address these challenges and to take these opportunities, we propose a robust and powerful two‐step testing procedure Local Ancestry Adjusted Allelic (LAAA) association. In the first step, LAAA robustly captures associations due to allelic effect, ancestry effect, and interaction effect, allowing detection of effect heterogeneity across ancestral populations. In the second step, LAAA identifies the source of association, namely allelic, ancestry, or the combination. By jointly modeling allele, local ancestry, and ancestry‐specific allelic effects, LAAA is highly powerful in capturing the presence of interaction between ancestry and allele effect. We evaluated the validity and statistical power of LAAA through simulations over a broad spectrum of scenarios. We further illustrated its usefulness by application to the Candidate Gene Association Resource (CARe) African American participants for association with hemoglobin levels. We were able to replicate independent groups’ previously identified loci that would have been missed in CARe without joint testing. Moreover, the loci, for which LAAA detected potential effect heterogeneity, were replicated among African Americans from the Women's Health Initiative study. LAAA is freely available at https://yunliweb.its. unc.edu/LAAA.