Miracle-dz/UniFAR-FTUs huggingface dataset:
Phytochemical Statistical Mapping of Red Grape Varieties Cultivated in Romanian Organic and Conventional Vineyards

Red grapes are rich in phytochemicals such as phenolics and flavonoids, which are strongly correlated with their antioxidant activity. Thus, grapes as-harvested and grape extracts, especially those obtained from their seeds and pulp, have been reported to have health benefits, and accordingly, grapes and their derivatives are considered potential functional food ingredients. The total phenolic content, total flavonoid content, and the antioxidant activity of skin, pulp, and seeds of four grape varieties grown both in conventional and organic vineyards were examined in this study. Phytochemical characteristics of one native Romanian variety, Feteasca Neagra, were compared with data measured for three red grape varieties more commonly cultivated worldwide (Merlot, Pinot Noir, and Muscat Hamburg). It was found that the seeds of the Pinot Noir variety grown in an organic system contained the highest total phenolics of 169.53 ± 7.32 mg gallic acid equivalents/g and the highest total flavonoid content of 388.25 ± 10.72 mg quercetin equivalents/g, values corresponding to high antioxidant activity (312.84 ± 12.81 mg ascorbic acid equivalents/g). The total flavonoid content in the hydroalcoholic extracts obtained from seeds of Pinot Noir (organic vineyard) was around 24.5-fold higher than that of the skin of Pinot Noir (conventional vineyard). Experiments showed that seeds of all four tested grape varieties are good sources of total flavonoids, not only of total phenolics. When referring to the organic vineyard, the skin and pulp grapes showed good results for the total phenolic content. The antioxidant activities of the hydroalcoholic extracts were well-correlated with the total phenolic content and total flavonoid content. Lower values of these parameters were found for extracts obtained from skin and pulp than for those obtained from seeds of the same grape variety regardless of the culture management system (organic/conventional). Data mining techniques such as regression analysis, principal component analysis, and clustering analysis were applied to establish the potential correlation between the phytochemical content and the antioxidant activities of the red grapes on the one hand, and grape variety, anatomical parts, and vineyard type (organic/conventional) on the other hand.
New Strategy for Comprehending the Significance of 3D Characteristics of Fingerprint, Correlation with 2D Model and Bridging in Between

: Our goal in this research is to demonstrate the bold outlines of our contemporary approach to the fingerprint. This approach includes multiple steps that require further refinement and investigation. We have come to the conclusion that the importance of 3D modeling of the fingerprint is perquisite to understand how the fingerprint is generated and could open a new frontier in forensic science.
Exploring the significance of tumor volume in endometrial cancer: Clinical pathological features, prognosis, and adjuvant therapies

To assist clinicians in formulating treatment strategies for endometrial cancer (EC), this retrospective study explores the relationship between tumor volume and clinical pathological features, as well as prognosis, in patients undergoing staging surgery. Preoperative pelvic MRI examinations were conducted on 234 histologically confirmed EC patients. The ITK-SNAP software was employed to manually delineate the region of interest in the MRI images and calculate the tumor volume (MRI-TV). The analysis focused on investigating the relationship between MRI-TV and the clinical pathological features and prognosis of EC patients. Larger MRI-TV was found to be associated with various adverse prognostic factors (G3, deep myometrial invasion, cervical stromal invasion, lymphovascular space invasion, lymph node metastasis, advanced international federation of gynecology and obstetrics staging, and receipt of adjuvant therapy). The receiver operating characteristic curve indicated that MRI-TV ≥ 8 cm3 predicted deep myometrial invasion, and MRI-TV ≥ 12 cm3 predicted lymph node metastasis. Penalized spline (P-spline) regression analysis identified 14 cm3 of MRI-TV as the optimal prognostic cutoff value. MRI-TV ≥ 14 cm3 was an independent prognostic factor for overall survival and disease-free survival. For patients with MRI-TV ≥ 14 cm3, the disease-free survival rate with adjuvant therapy was superior to that of the sole staging surgery group. This study demonstrates a significant correlation between MRI-TV and clinical pathological features and prognosis in EC. For patients with MRI-TV ≥ 14 cm3, staging surgery followed by adjuvant therapy was superior to sole staging surgery.
Sodium L-Aspartate Supplementation Improves Repeated-Sprint Performance

Aspartate supplementation has been reported to improve endurance performance by facilitating the tricarboxylic acid cycle flux. The present study was performed to investigate the effects of aspartate supplementation on repeated-sprint performance and blood pH. Following an overnight fast, fourteen healthy males completed three sets of 10 × 6 s maximal sprints after consuming sodium L-aspartate (ASP) or placebo (PLA), in a double-blind manner. Both supplements were taken twice on each test day (2 × 4.5 g). Exercise performance (e.g., cadence and power output) and blood variables (e.g., pH and plasma amino acid levels) were measured. The ASP trial evidenced significantly higher plasma aspartate concentration during the first (ASP, 45.3 ± 9.2 μM; PLA, 6.1 ± 0.8 μM) and the second exercise sets (ASP, 24.2 ± 4.5 μM; PLA, 6.6 ± 0.9 μM) and peak cadence during the second set (ASP, 153 ± 3 rpm; PLA, 152 ± 3 rpm) compared with the PLA trial (all p < 0.05). The peak power output during the second exercise set (ASP, 743 ± 32 W; PLA, 734 ± 31 W; p = 0.060) and the blood pH immediately before (ASP, 7.280 ± 0.020; PLA, 7.248 ± 0.016; p = 0.087) and after the third exercise set (ASP, 7.274 ± 0.019; PLA, 7.242 ± 0.018; p = 0.093) tended to be higher in the ASP than in the PLA trial. In conclusion, ASP supplementation partially improved repeated-sprint performance (peak cadence during the second exercise set). However, it did not affect the mean power output.
Problematic Gaming during COVID-19 Pandemic: A Systematic Review, Meta-Analysis, and Meta-Regression

The COVID-19 pandemic led to government measures enforcing isolation in order to mitigate the spread of the virus. Consequently, online activities, including gaming, increased during this challenging period. Thus, it was possible that problematic gaming (PG) patterns also increased. In this systematic review and meta-analysis, we estimated the prevalence of PG during the COVID-19 pandemic and examined differences among subpopulations. The evaluation of 38 studies revealed that the overall prevalence of PG during the COVID-19 pandemic was 3.6%. Furthermore, higher PG scores were found in undergraduate and gamer subpopulations, as well as in studies using the Gaming Addiction Scale. Finally, meta-regression analyses suggest that stricter government measures, as identified by the Government Stringency Index, may have contributed to a lower prevalence of PG behaviors. A potential explanation of this finding is that containment measures had a protective function with respect to emotional distress, and thus towards PG; alternatively, it could be that current measures for PG become less precise if an individual’s functioning is already impaired due to other reasons, such as COVID-19 restrictions. Further theoretical, methodological, and practical implications of the findings are discussed.
High Gradient Labelling-free Isolation of Cardiomyocytes from Heterogeneous Populations

Heart disease is the leading cause of death in the world and is likely to remain so in the foreseeable future. There is a great deal of optimism about cardiac regenerative therapies because recent advances in stem cell technology have made it possible to derive millions of cardiomyocytes, i.e., functional heart muscle cells, from human embryonic stem cells and induced pluripotent stem cells. These stem cell-derived cardiac cells also have enormous potential in drug discovery, toxicology studies and fundamental cardiac physiology. Cardiomyocytes (CMs) do not have well-established, specific surface markers, which could enable their separation from heterogeneous differentiation cultures using transient antibody labelling and traditional methods such as fluorescence activated cell sorting (FACS) or magnetic activated cell sorting (MACS). The next major challenge in realizing their potential is the development of separation methods that are compatible with clinical applications and can isolate cardiomyocytes and specific cardiac cell subpopulations in sufficient numbers, purity and quality after in vitro culture. This thesis presents a review of currently available cardiomyocyte separation strategies; develops a mathematical model to describe the novel labeling-free application of high gradient magnetic sorting for cardiomyocytes; reports the CM separation conducted; and finally avalidates a CM prosurvival preconditioning strategy to protect against an in vitro simulated ischemic/reperfusion injury such as one that occurs after cells are implantation in vivo. Neonatal rat and hESC-derived cardiomyocytes were collected at 94.8±3.3% and
Hepatorenal Syndrome—Novel Insights into Diagnostics and Treatment

Hepatorenal syndrome (HRS) is a disorder associated with cirrhosis and renal impairment, with portal hypertension as its major underlying cause. Moreover, HRS is the third most common cause of acute kidney injury, thus creating a major public health concern. This review summarizes the available information on the pathophysiological implications of HRS. We discuss pathogenesis associated with HRS. Mechanisms such as dysfunction of the circulatory system, bacterial infection, inflammation, impaired renal autoregulation, circulatory, and others, which have been identified as critical pathways for development of HRS, have become easier to diagnose in recent years. Additionally, relatively recently, renal dysfunction biomarkers have been found indicating renal injury, which are involved in the pathophysiology of HRS. This review also summarizes the available information on the management of HRS, focusing on vasoconstrictive drugs, renal replacement therapy, and liver transplant together with currently being investigated novel therapies. Analyzing new discoveries for the underlying causes of this condition assists the general research to improve understanding of the mechanism of pathophysiology and thus prevention of HRS.
Intonation processing of interrogative words in Mandarin: an event-related potential study

Intonation is the variation in pitch used in speech, which forms the premise of tonal and non-tonal languages. Interrogative words are words that introduce questions. Previous research lacks clarity regarding the specific cues used in the processing of word intonation. To address this gap, this study used the event-related potential electroencephalogram (EEG) research method to explore the intonation processing of tone two (mid-rising) interrogative words in Mandarin. For this, the word “shui,” meaning “who,” was selected as the experimental material. To avoid the influence of the environment, gender, and semantics, the Hum version, corresponding to the stimulus material, was also adopted for the experiment. This study used a passive oddball paradigm to examine the clues of intonation information processing in automatic cognitive processing through amplitude, latency, time window, and evoked location potential mismatch negativity. The standard stimulus was the declarative intonation with a high probability of occurrence (90%), and the deviant stimulus was the interrogative intonation with a low probability of occurrence (10%). In the time window of 370–450 ms, the mismatch negativity was found at the F3, F4, C3, Cz, and C4 channels. The findings show that, in the passive oddball paradigm, lexical semantics are essential for intonation processing at the pre-attentive level, which is dominated by the frontal and central areas of the brain. The results support the functional and comprehensive hypotheses that the processing of intonation is based on the function of language and that bilateral regions are involved in this processing. This study makes an important contribution by providing event-related potential evidence that lexical semantics plays a key role in the pre-attentive processing of intonation, as shown by the significant differences between semantic and non-semantic conditions.
Effects of New CAP Reform and Trends in Sustainable Olive Growing Systems in Southern Spain

This contribution analyzes the adoption of integrated and organic olive farming, and the likely impacts of the new CAP reform on diverse olive farming systems in Andalusia, Spain. We use statistical methods for the former and a Positive Mathematical Programming model calibrated with the neutral procedure for the latter. The PMP model compares the situation of the average olive farm in base year with its position in a simulated year using two policy scenarios. Results indicate that the new rules on green payment don’t incentive the adoption of sustainable systems, although they don’t prevent the development of these systems whose sustained growth seems to be largely independent from market circumstances and agricultural policies. An alternative policy advocating the implementation of green payment scheme in the olive sector would lead to a better redistribution of public support from less to more environmentally-friendly farming practices, contributing to enhance the CAP aids legitimacy.
Impacts of Building Environment and Urban Green Space Features on Urban Air Quality: Focusing on Interaction Effects and Nonlinearity

Air pollution is a rising environmental concern that has detrimental effects on human health and the environment. Building environment and urban green space features play a crucial role in the dispersion and accumulation of air pollutants. This study examines the impacts of building environment and urban green space on air pollution levels in the highly urbanized city of Hong Kong, focusing on their interaction effects and potential nonlinearity. For the analysis, this paper investigates how building density, building height, building types, urban green space size, and number of urban green space clusters, as well as their interplays, impact PM2.5 concentrations using high-resolution, satellite-based PM2.5 grids coupled with spatial analysis techniques. The findings reveal that a unit increase in the size of urban green space and the standard deviation of building height contribute to a 0.0004 and a 0.0154 reduction in PM levels, respectively. In contrast, air pollution levels are found to be positively associated with building density (0.1117), scatteredness of urban green space (0.0003), and share of commercial buildings (1.0158). Moreover, it has been found that building height presents a U-shape relationship with PM2.5 concentrations. Finally, the negative association between the size of urban green space and air pollution levels tends to be enlarged in districts with more low-rise buildings. This study conveys important building environment and urban green space planning implications.
Antioxidant Response, Phenolic Compounds and Yield of Solanum tuberosum Tubers Inoculated with Arbuscular Mycorrhizal Fungi and Growing under Water Stress

Solanum tuberosum (potato) is one of the most common crops worldwide; however, it is sensitive to water stress, which necessitates the identification of alternative tools to improve their production. Here, we evaluated the inoculation of two arbuscular mycorrhizal fungi (AMF) strains, Claroideoglomus claroideum (CC), Claroideoglomus lamellosum (HMC26), and the MIX (CC + HMC26) in yield and phenolic and antioxidant response using chromatographic and spectroscopic methods in potato crops, at increasing levels of water stress, namely, with 100% (0), 70% (S1), and 40% (S2) soil humidity. Two caffeoylquinic acid isomers were detected and their levels showed a tendency to increase under stress together with the AMF inoculation, reaching up to 19.2 mg kg−1 of 5-caffeoylquinic acid and 7.4 mg kg−1 of caffeoylquinic acid isomer when CC was inoculated, and potato plants grew at the highest water starvation condition (S2). Regarding antioxidant activities, a differentiated response was detected depending on the AMF strain, highlighting the effect of HMC26 on Trolox equivalent antioxidant capacity (TEAC) method and CC in cupric reducing antioxidant capacity (CUPRAC) method, reaching up to 1.5 μmol g−1 of TEAC in plants inoculated with HMC26 and 0.9 μmol g−1 of CUPRAC in plants inoculated with CC, both in potato tubers of plants growing under the S2 stress condition. Meanwhile, the use of AMF did not influence the number and biomass of the tubers, but significant changes in the biochemical properties of tubers were observed. The results suggest that specific AMF adaptations to water stress must be considered when inoculation procedures are planned to improve the yield and quality of tubers in potato crops.
Design of Compact Ultra-Wideband Monopole Semi-Circular Patch Antenna for 5G wireless communication networks

This paper presents , a novel design of semi-circular patch antenna for Ultra-wideband (UWB) wireless communication systems. The monopole is compact with structure size of 25x25 mm and thickness of 1.6 mm. It has been fabricated on a FR-4 substrate with relative permittivity of Ɛr=4.4. The designed antenna has an ultrawide bandwidth, from 3GHz to 11.5 GHz based on -10dB criteria, which covers the entire UWB allocated by FCC for such applications. Also, the design shows high performance in terms of impedance match between feeding line and radiator. Radiation pattern results have been studied at all resonant frequencies (3 GHz to 11.5 GHz) and they have almost omni directional pattern. The monopole has been fabricated and experimentally measured for verification and both simulation and experimental results show good agreement. The overall antenna gain is 1.8 dBi with bandwidth of 125% for UWB. Therefore, the simulated and measured results confirm that the antenna satisfies the requirements for ultra-wideband applications. Design, simulation, and optimization process have been completed using industrial simulation software called High Frequency Structural Simulator (HFSS). Streszczenie. W artykule opisano projekt półokrągłej anteny szerokopasmowej do systemów WiFi. Antena ma powierzchnię 25x25 mm i grubość 1.6 mm. Psamo częstotliwościowe antent jest od 3 GHz do 11.5 GHz. Symulacje I pomiary potwierdziły przydatność tej antny do pasma UWB. Projekt kompaktowej ultra-szerokopasmowej anteny do bezprzewodowej komunikacji 5G
Targeting colorectal cancer cells using AND-gated adaptor RevCAR T-cells

Despite the success of chimeric antigen receptor (CAR) T-cells especially for treating hematological malignancies, critical drawbacks, such as “on-target, off-tumor” toxicities, need to be addressed to improve safety in translating to clinical application. This is especially true, when targeting tumor-associated antigens (TAAs) that are not exclusively expressed by solid tumors but also on hea9lthy tissues. To improve the safety profile, we developed switchable adaptor CAR systems including the RevCAR system. RevCAR T-cells are activated by cross-linking of bifunctional adaptor molecules termed target modules (RevTM). In a further development, we established a Dual-RevCAR system for an AND-gated combinatorial targeting by splitting the stimulatory and co-stimulatory signals of the RevCAR T-cells on two individual CARs. Examples of common markers for colorectal cancer (CRC) are the carcinoembryonic antigen (CEA) and the epithelial cell adhesion molecule (EpCAM), while these antigens are also expressed by healthy cells. Here we describe four novel structurally different RevTMs for targeting of CEA and EpCAM. All anti-CEA and anti-EpCAM RevTMs were validated and the simultaneous targeting of CEA+ and EpCAM+ cancer cells redirected specific in vitro and in vivo killing by Dual-RevCAR T-cells. In summary, we describe the development of CEA and EpCAM specific adaptor RevTMs for monospecific and AND-gated targeting of CRC cells via the RevCAR platform as an improved approach to increase tumor specificity and safety of CAR T-cell therapies.
The Impact of Legislation on the Hazard of Female Genital Mutilation/Cutting: Regression Discontinuity Evidence from Burkina Faso

In 1996, Burkina Faso enacted legislation banning the practice of female genital mutilation/cutting (FGM/C). Much of the qualitative literature surrounding FGM/C discounts the impact of legal change on what is considered a social/cultural issue. We use data from the Demographic and Health Surveys DHS(VI) in Burkina Faso to test for a discontinuous change in the likelihood of being cut in the year the law was passed. We ﬁnd robust evidence for a substantial drop in hazard rates in 1996 and investigate the heterogeneous impact of the law by region, religion, and ethnicity. Overall, we roughly estimate that over a ten year period the law averted the genital mutilation/cutting of approximately 237,591 women and girls. We qualify our ﬁndings recognizing that Burkina Faso is a special case with a long history of bottom-up and top-down approaches to eliminating the practice.
Trends in air temperature and atmospheric precipitation in Botosani between 1961 and 2017

: Air temperature and precipitations are major factors affecting the climate of a certain place. They define the basic matrix of the climate, and their evolution are of interest for the whole of both human and scientific community. The purpose of the present study is to highlight the sign and the magnitude of the trend in the air temperature at Botoşani city weather station for the whole period 1961-2017, and for both its major subdivisions (1961-1990 and 1991-2017, respectively) throughout different temporal subsets (from the level of an average year to the level of a month). Besides air temperature, we determined the evolutive trend in the amount of rainfall using a similar methodology (based mainly on the Mann-Kendall and t tests). Following our approach, we showcased the thermal and pluviometric reality at Botoşani , which is in a continuous change (as for the temperature values) or in a relatively dynamic balance (with respect to the amount of precipitations). More precisely, at Botoşani , against an annual average temperature of 9.4°C and an annual average of precipitations of 569.0 mm, after the year 1961 and mostly after 1990, the tendency was positive, which indicates an increase in air temperature. From a thermal point of view, considered annualy, seasonally and by
Organoids: A New Approach for Clinical Trial in a Dish

: Organiods, sometimes referred to as organs in a dish, have transformed the disciplines of biological and medical research, and the technology has proven to be a great animal model substitute in preclinical investigations, immunotherapy, and stem cell biology. Organoids are three-dimensional (3D) cell culture systems that are sometimes referred to as "mini-organs" because they closely resemble certain important multicellular, anatomical, and even functional traits of actual organs.Organoids are effective tools for studying individual illnesses and developing specialized treatments. This cutting-edge technology has increased the likelihood that medications will be translatable for use in preclinical therapies and mimicked the complexity of organs, proposing a variety of methods for tissue engineering, drug development, diagnosis and regenerative medicine. There are numerous technologies that are connected to organoids, which may lead to wonders in the future.