Miracle-dz/UniFAR-FTUs huggingface dataset:
Cervical cancer detection using K nearest neighbor imputer and stacked ensemble learningmodel

Objective Cervical cancer stands as a leading cause of mortality among women in developing nations. To ensure the reduction of its adverse consequences, the primary protocols to be adhered to involve early detection and treatment under the guidance of expert medical professionals. An effective approach for identifying this form of malignancy involves the examination of Pap smear images. However, in the context of automating cervical cancer detection, many of the existing datasets frequently exhibit missing data points, a factor that can substantially impact the effectiveness of machine learning models. Methods In response to these hurdles, this research introduces an automated system designed to predict cervical cancer with a dual focus: adeptly managing missing data while attaining remarkable accuracy. The system's core is built upon a stacked ensemble voting classifier model, which amalgamates three distinct machine learning models, all harmoniously integrated with the KNN Imputer to address the issue of missing values. Results The model put forth attains an accuracy of 99.41%, precision of 97.63%, recall of 95.96%, and an F1 score of 96.76% when incorporating the KNN imputation method. The investigation conducts a comparative analysis, contrasting the performance of this model with seven alternative machine learning algorithms in two scenarios: one where missing values are eliminated, and another employing KNN imputation. This study offers validation of the effectiveness of the proposed model in comparison to current state-of-the-art methodologies. Conclusions This research delves into the challenge of handling missing data in the dataset utilized for cervical cancer detection. The findings have the potential to assist healthcare professionals in achieving early detection and enhancing the quality of care provided to individuals affected by cervical cancer.
c-Cbl Regulates Murine Subventricular Zone-Derived Neural Progenitor Cells in Dependence of the Epidermal Growth Factor Receptor

The localization, expression, and physiological role of regulatory proteins in the neurogenic niches of the brain is fundamental to our understanding of adult neurogenesis. This study explores the expression and role of the E3-ubiquitin ligase, c-Cbl, in neurogenesis within the subventricular zone (SVZ) of mice. In vitro neurosphere assays and in vivo analyses were performed in specific c-Cbl knock-out lines to unravel c-Cbl’s role in receptor tyrosine kinase signaling, including the epidermal growth factor receptor (EGFR) pathway. Our findings suggest that c-Cbl is significantly expressed within EGFR-expressing cells, playing a pivotal role in neural stem cell proliferation and differentiation. However, c-Cbl’s function extends beyond EGFR signaling, as its loss upon knock-out stimulated progenitor cell proliferation in neurosphere cultures. Yet, this effect was not detected in hippocampal progenitor cells, reflecting the lack of the EGFR in the hippocampus. In vivo, c-Cbl exerted only a minor proneurogenic influence with no measurable impact on the formation of adult-born neurons. In conclusion, c-Cbl regulates neural stem cells in the subventricular zone via the EGFR pathway but, likely, its loss is compensated by other signaling modules in vivo.
Risk perception and crisis communication during the Covid-19 pandemic: Analysis based on Twitter hashtags

This research evaluates response strategies to crisis communication, in terms of perceived risks, in organizations during the Covid-19 pandemic by studying the main discussion topics in social media. The data was collected from Twitter between March and April 2020. By using big data software, a total number of 3559255 tweets in different languages were extracted worldwide from Twitter API of popular hashtags on the Covid-19 pandemic. The data processing was carried out through the association of terms in order to identify patterns and relationships in the discussion topics. The results indicate that the relationships of the terms "crisis" and "risks" were statistically significant with seven important topics for businesses, users, and consumers: "business", "economic and financial", "social"," health"," work"," family" and "government"; and in turn these seven topics are related to other terms related to the impact of the crisis, the response to the crisis, aid, the watch out, and support. This research has implications for the situational crisis communication theory by showing that in situations with high perceived risk, such as the Covid-19 pandemic crisis, the use of crisis response strategies predominates in organizations. This research also has implications for managers who can use crisis response strategies to rebuild their reputation and avoid market losses, thus helping to reduce the effects of unpredictable crisis situations.
ZITA: Zero-Interaction Two-Factor Authentication using Contact Traces and In-band Proximity Verification

—Two-factor authentication (TFA) provides an additional layer of protection to commonly-occurring password breaches. However, existing TFA methods, often involve special hardware interfaces, or require human effort which is prone to errors and acts as an adoption detractor for older adults and novice technology users. To address these limitations, we propose a zero-interaction, two-factor authentication (ZITA) protocol. In ZITA, the first factor is implemented using the conventional username and password methods. The second factor is completed without any human effort provided that the user is not accessing the service from an unregistered public device and a designated secondary device is physically co-present. To automate the second factor, ZITA exploits the long-term contact between the login device and the secondary device such as a smartphone. Moreover, to thwart man-in-the-middle and co-located attacks, ZITA incorporates a proximity verification test that relies on the randomness of ambient RF signals. Compared with other zero-effort TFA protocols, ZITA remains secure against advanced threats and does not require out-of-band sensors such as microphones, speakers, or photoplethysmography (PPG) sensors.
Shallow-depth melt eduction due to ridge subduction: LA-ICPMS U-Pb igneous and detrital zircon ages from the Chile Triple Junction and the Taitao Peninsula, Chilean Patagonia

Copyright © 2013 by The Geochemical Society of Japan. to understand not only the processes of magma genesis but also the formation of initial continental crusts (Nelson and Forsythe, 1989). Among current ridge subduction zones (e.g., McCrory et al., 2009), the Chile Triple Junction (CTJ) (Fig. 1a) is expected to be the best example for a case study because: (1) the subducting ridge system is a topographically prominent feature; (2) the half-spread-rate is ~4 cm/y, and a significant portion of the world’s oceanic crust has formed under such a rate; and (3) the mid axes of the Chile Ridge system are sub-parallel to the continental margin, and thus along-arc and across-arc variation is expected. A chain of active volcanoes in the Southern Volcanic Zone (SVZ) extends from low latitudes along the Andean Mountains (Fig. 1a) and is disrupted at Hudson Volcano (H in Fig. 1a) near the latitude of CTJ. To the south from CJT, active volcanoes of the Austral Volcanic Zone (AVZ) are sparsely distributed (e.g., Stern et al., 1976; Ramos, 1989; Stern, 2004 and references therein). Volcanoes of SVZ typically have basaltic to andesitic compositions with arc-signatures whereas those of AVZ have adakitic comShallow-depth melt eduction due to ridge subduction: LA-ICPMS U–Pb igneous and detrital zircon ages from the Chile Triple Junction and the Taitao Peninsula, Chilean Patagonia
Thermal conductivity of unconsolidated sediments with geophysical applications

A theoretical model for the prediction of the thermal conductivity of unconsolidated granular sediments, with application to sand shale mixtures, is presented. The sediment is modeled as an assemblage of grains of thermal conductivity λS immersed in a pore fluid of thermal conductivity λƒ. In order to take into account for the thermal interactions between the grains a differential effective medium approach is used to provide a relationship between the effective thermal conductivity of the isotropic mixtures of grains saturated by the pore fluid, the porosity, and the thermal conductivities of the grains and pore fluid. The influence of the topology of the interconnected pore space is accounted for through the use of the electrical cementation exponent m, which is related to the electrical formation factor F by F = ϕ−m, where ϕ is the interconnected porosity. The main assumption of the model lies in the small contiguity between the grains. This assumption holds well for unconsolidated sand shale mixture sediments as demonstrated by comparing the model to available experimental data. The model offers the possibility to derive thermal conductivity profiles from downholes measurements of natural radioactivity, electrical resistivity, and bulk density.
Iron mobilization in mineral dust: Can anthropogenic SO2 emissions affect ocean productivity?

For Fe contained in long‐range transported aeolian dust to act as a micronutrient for oceanic phytoplankton it must be first dissolved or mobilized. We propose that Fe‐mobilization can occur in mineral dust from East Asia by the incorporation of SO2 into the advecting dust plumes and subsequent acidification of the dust through heterogeneous SO2 oxidation. To test this hypothesis, we consider a dust plume that originated from the gobi‐deserts and advected over the Pacific Ocean. Data collected over the Yellow Sea confirm that this plume contained high concentrations of dust and SO2. Significant gaseous HNO3 concentrations indicate that the dust particles were acidified (i.e., pH < 2). At these pH's, 1–2% of the Fe contained in a deliquescent mineral dust particle would be mobilized within 3–5 days. These results suggest a possible link between the rate of C‐fixation in so‐called High‐Nitrate‐Low‐Chlorophyll regions of the Pacific Ocean and SO2 emissions from East Asia.
39Ar‐40Ar dating of the Zagami Martian shergottite and implications for magma origin of excess 40Ar

Abstract— The Zagami shergottite experienced a complex, petrogenetic formation history (McCoy et al. 1992, 1999). Like several shergottites, Zagami contains excess 40Ar relative to its formation age. To understand the origin of this excess 40Ar, we made 39Ar‐40Ar analyses on plagioclase and pyroxene minerals from two phases representing different stages in the magma evolution. Surprisingly, all these separates show similar concentrations of excess 40Ar, ˜1 × 10−6 cm3/g. We present arguments against this excess 40Ar having been introduced from the Martian atmosphere as impact glass. We also present evidence against excess 40Ar being a partially degassed residue from a basalt that actually formed ˜4 Gyr ago. We utilize our experimental data on Ar diffusion in Zagami and evidence that it was shock‐heated to only ˜70 °C, and we assume this heating occurred during an ejection from Mars ˜3 Myr ago. With these constraints, thermal considerations necessitates either that its ejected mass was impossibly large, or that its shock‐heating temperature was an order of magnitude higher than that measured. We suggest that this excess 40Ar was inherited from the Zagami magma, and that it was introduced into the magma either by degassing of a larger volume of material or by early assimilation of old, K‐rich crustal material. Similar concentrations of excess 40Ar in the analyzed separates imply that this magma maintained a relatively constant 40Ar concentration throughout its crystallization. This likely occurred through volatile degassing as the magma rose toward the surface and lithostatic pressure was released. These concepts have implications for excess 40Ar in other shergottites.
Rainfall variations in the tropics during 1986-1989, as estimated from observations of cloud-top temperature

Large-scale shifts in rainfall in the tropics, particularly the western tropical Pacific, were observed during the transition from “warm” (1986–1987) to “cold” (1988–1989) El Nino/Southern Oscillation (ENSO) conditions. Differences in the estimated rainfall rate in excess of 20 mm d−1 were observed south of the equator, near the international date line, between the northern winter seasons of 1986–1987 and 1988–1989. The distribution of zonal mean rainfall varied significantly during the study period, as did monthly accumulated rainfall in the global tropics, where the difference between the wettest and driest months for the period January 1986 through May 1989 was 24%. No direct measurements (rain gage, radar) of large-scale areal-averaged rainfall are available for the global tropics, hence rainfall estimates, as inferred from satellite observations of cloud-top temperature, are used in this paper. A qualitative comparison of the behavior of the rainfall estimates during the 1986–1989 period with the expected rainfall anomaly patterns in regions with known rainfall responses to both the low (“warm”) and high (“cold”) Southern Oscillation Index (SOI) phases of ENSO phenomena is presented. The comparison indicates that rainfall variation during 1986–1989 in these regions behaved as expected, for the most part, for both phases of the ENSO cycle. The rainfall patterns are also compared to observed moisture and vertical motion fields in the atmosphere and sea surface temperature (SST) during this period.
Innovation of Digital-Based Licensing Services in the One-Stop Integrated Service of West Sulawesi Province

The rapid development of information and communication technology (ICT) in the digital era has compelled the government to adapt by innovating governance through electronic-based systems, especially in public service delivery. The Government of West Sulawesi has also embraced this digital transformation and introduced ”digital service innovation” in the One-Stop Integrated Service (PTSP) of the province. One such innovation is the online licensing application (SAPO) system. This study aimed to assess the implementation, quality, and impact of the SAPO system on society. A quantitative approach with a survey type was used for data collection, along with literature studies. The findings reveal that the digital-based licensing service innovation has brought significant improvements in the quality and quantity of licensing services in the One-Stop Integrated Services of West Sulawesi Province. However, further efforts are needed to strengthen and mature the service quality to ensure that the impact of this innovation is maximally felt by the community. Keywords: digital, innovation, licensing services, public service
Comment on “Evidence for O‐atom exchange in the O(1D) + N2O reaction as the source of mass‐independent isotopic fractionation in atmospheric N2O” by Y. L. Yung et al.

[1] Yung et al. [2004] (hereinafter referred to as Y04) suggest that non-quenching oxygen isotope exchange in the reaction N2O + O( D) could be a significant source of the oxygen isotope anomaly in atmospheric N2O, analogous to isotope exchange between CO2 and O( D) [Perri et al., 2003]. Unfortunately, the authors ignored much of the relevant literature and did not discuss consequences of an exchange channel for existing kinetic data. Ample indirect observational evidence exists in the literature against such an isotope exchange. Also, a barrier in one reaction channel, which is suggested to enable the transfer, is not seen in more advanced calculations. Furthermore, the process of ‘‘quantifying’’ the proposed mechanism using the three-isotope slope of atmospheric observations and model results is not valid.
Drug Loaded 3D-Printed Poly(ε-Caprolactone) Scaffolds for Local Antibacterial or Anti-Inflammatory Treatment in Bone Regeneration

Annual bone grafting surgeries due to bone fractures, resections of affected bones, skeletal anomalies, osteoporosis, etc. exceed two million worldwide. In this regard, the creation of new materials for bone tissue repair is one of the urgent tasks of modern medicine. Additive manufacturing, or 3D printing, offers great opportunities for the development of materials with diverse properties and designs. In this study, the one-pot technique for the production of 3D scaffolds based on poly(ε-caprolactone) (PCL) loaded with an antibiotic or anti-inflammatory drug was proposed. In contrast to previously described methods to prepare drug-containing scaffolds, drug-loaded PCL scaffolds were prepared by direct 3D printing from a polymer/drug blend. An investigation of the mechanical properties of 3D-printed scaffolds containing 0.5–5 wt% ciprofloxacin (CIP) or dexamethasone (DEX) showed almost no effect of the drug (compression modulus ~70–90 MPa) compared to unfilled PCL (74 MPa). At the same time, introducing the drug and increasing its content in the PCL matrix contributed to a 1.8–6.8-fold decrease in the specific surface area of the scaffold, depending on composition. The release of CIP and DEX in phosphate buffer solution and in the same buffer containing lipase revealed a faster release in enzyme-containing medium within 45 days. Furthermore, drug release was more intensive from scaffolds with a low drug load. Analysis of the release profiles using a number of mathematical dissolution models led to the conclusion that diffusion dominates over other probable factors. In vitro biological evaluation of the scaffolds containing DEX showed moderate toxicity against osteoblast-like and leukemia monocytic cells. Being 3D-printed together with PCL both drugs retain their biological activity. PCL/CIP and PCL/DEX scaffolds demonstrated antibacterial properties against Pseudomonas aeruginosa (a total inhibition after 48 h) and anti-inflammatory activity in experiments on TNFα-activated monocyte cells (a 4-time reduction in CD-54 expression relative to control), respectively.
NEw observations of the NOy/N2O correlation in the lower stratosphere

During the Airborne Arctic Stratospheric Expedition II (AASE II), September 1991 through March 1992, in situ measurements of reactive nitrogen (NO[sub y]) and N[sub 2]O were made in the Northern Hemisphere lower stratosphere. The authors present an analysis of this new data and compare it with results from similar data taken during AASE in the winter of 1989. In the Northern Hemisphere there is a consistent linear correlation of N[sub 2]O and NO[sub y] which shows no interannual variation. Cases of departure from a linear correlation are examined and classified as being due to denitrification (NO[sub y] loss) or sampling air from a region where the photochemical lifetime of NO[sub y] is decreased. The latter case was observed for the first time in the winter of 1992. 19 refs., 4 figs., 1 tab.
Comparison of unfiltered radiances measured by CERES instruments aboard the S-NPP and Terra/Aqua satellites

The main focus of this paper is a comparison of unfiltered radiances measured by CERES instruments operating on three different platforms, namely the Suomi-NPP, Terra and Aqua satellites. Data for the comparison have been continuously collected since FM5 aboard the S-NPP started its science mission in February of 2012. Three difference strategies have been devised for the purpose of comparing CERES scanners, and two of them utilize a special scanning mode. Since in all three strategies viewing geometries of instruments (FM5 and FM3, and also FM5 and FM1) are matched, comparison at the unfiltered radiance level is enabled. This approach provides a data set with reduced uncertainties for comparing shortwave channels, and also outgoing daytime longwave radiation. Gridded averages are mainly processed to determine differences in scanner’s measurements, and statistics are computed primarily for “all-sky” conditions. However, in one of the strategies, comparison is done at a footprint level for a more stringent test of the consistency between the two instruments (FM5 and FM3) for specific scene types. Results of the unfiltered radiance comparison are based on ES8 or ERBE-like data product using Edition-1 for FM5, and Edition-3 for FM1 and FM3.
Monitoring Land Subsidence in Mexico City with Envisat ASAR Interferometry

A wall type combination faucet structure in which a balancer is located and prevented from being displaced so as to avoid leakage at adjoining portion between the balancer and the faucet body. The adjoining portions between the open end of the faucet body and the cold and hot water inlets are forcedly sealed to achieve a good leakproof effect. The handle can be rotated within 0 degree to 135 degrees to accurately adjust the necessary water temperature. The thread sleeve can be screwed into or out of the cavity to a certain extent so as to shade the exposed clearance between the handle knob and the large decorative cap and achieve a good appearance of the faucet body as well as retain and balance the handle knob.
Hyperspectral imaging for the detection of retinal disease

Hyperspectral imaging (HSI) shows great promise for the detection and classification of several diseases, particularly in the fields of "optical biopsy" as applied to oncology, and functional retinal imaging in ophthalmology. In this paper, we discuss the application of HSI to the detection of retinal diseases and technological solutions that address some of the fundamental difficulties of spectral imaging within the eye. HSI of the retina offers a route to non-invasively deduce biochemical and metabolic processes within the retina. For example it shows promise for the mapping of retinal blood perfusion using spectral signatures of oxygenated and deoxygenated hemoglobin. Compared with other techniques using just a few spectral measurements, it offers improved classification in the presence of spectral cross-contamination by pigments and other components within the retina. There are potential applications for this imaging technique in the investigation and treatment of the eye complications of diabetes, and other diseases involving disturbances to the retinal, or optic-nerve-head circulation. It is well known that high-performance HSI requires high signal-to-noise ratios (SNR) whereas the application of any imaging technique within the eye must cope with the twin limitations of the small numerical aperture provided by the entrance pupil to the eye and the limit on the radiant power at the retina. We advocate the use of spectrally-multiplexed spectral imaging techniques (the traditional filter wheel is a traditional example). These approaches enable a flexible approach to spectral imaging, with wider spectral range, higher SNRs and lower light intensity at the retina than could be achieved using a Fourier-transform (FT) approach. We report the use of spectral imaging to provide calibrated spectral albedo images of healthy and diseased retinas and the use of this data for screening purposes. These images clearly demonstrate the ability to distinguish between oxygenated and deoxygenated hemoglobin using spectral imaging and this shows promise for the early detection of various retinopathies.