Miracle-dz/UniFAR-FTUs huggingface dataset:
Constitutive Phosphorylation of Cardiac Myosin Regulatory Light Chain in Vivo*

Background: Myosin regulatory light chain phosphorylation is necessary for normal cardiac performance. Results: Regulatory light chain phosphorylation is not affected by conditions affecting phosphorylation of other sarcomeric proteins, including β-adrenergic tone. Conclusion: Significant regulatory light chain phosphorylation in beating hearts is sustained physiologically by low cMLCK and MLCP activities. Significance: Constitutive regulatory light chain phosphorylation stabilizes cardiac performance. In beating hearts, phosphorylation of myosin regulatory light chain (RLC) at a single site to 0.45 mol of phosphate/mol by cardiac myosin light chain kinase (cMLCK) increases Ca2+ sensitivity of myofilament contraction necessary for normal cardiac performance. Reduction of RLC phosphorylation in conditional cMLCK knock-out mice caused cardiac dilation and loss of cardiac performance by 1 week, as shown by increased left ventricular internal diameter at end-diastole and decreased fractional shortening. Decreased RLC phosphorylation by conventional or conditional cMLCK gene ablation did not affect troponin-I or myosin-binding protein-C phosphorylation in vivo. The extent of RLC phosphorylation was not changed by prolonged infusion of dobutamine or treatment with a β-adrenergic antagonist, suggesting that RLC is constitutively phosphorylated to maintain cardiac performance. Biochemical studies with myofilaments showed that RLC phosphorylation up to 90% was a random process. RLC is slowly dephosphorylated in both noncontracting hearts and isolated cardiac myocytes from adult mice. Electrically paced ventricular trabeculae restored RLC phosphorylation, which was increased to 0.91 mol of phosphate/mol of RLC with inhibition of myosin light chain phosphatase (MLCP). The two RLCs in each myosin appear to be readily available for phosphorylation by a soluble cMLCK, but MLCP activity limits the amount of constitutive RLC phosphorylation. MLCP with its regulatory subunit MYPT2 bound tightly to myofilaments was constitutively phosphorylated in beating hearts at a site that inhibits MLCP activity. Thus, the constitutive RLC phosphorylation is limited physiologically by low cMLCK activity in balance with low MLCP activity.
Telepathology in Cytopathology: Challenges and Opportunities

Objective: Telepathology in cytopathology is becoming more commonly utilized, and newer technologic infrastructures afford the laboratory a variety of options. The options and design of a telepathology system are driven by the clinical needs. This is primarily focused on providing rapid on-site evaluation service for fine needle aspiration. Study Design: The clinical requirements and needs of a system are described. Available tools to design and implement a telepathology system are covered, including methods of image capture, network connectivity and remote viewing options. Results: The primary telepathology method currently used and described involves the delivery via a network connection of a live video image to a remote site which is passively viewed by an internet web-based browser. By utilizing live video information and a voice connection to the on-site location, the remote viewer can collect clinical information and direct their view of the slides. Conclusions: Telepathology systems for use in cytopathology can be designed and implemented with commercially available infrastructure. It is necessary for the laboratory to validate the designed system and adhere to the required regulatory requirements. Telepathology for cytopathology can be reliably utilized by adapting existing technology, and newer advances hold great promise for further applications in the cytopathology laboratory.
The relationship between critical success factors of total quality management and process improvement: a case study

Companies’ urge to survive in today’s highly competitive globalised market and their attempts to maximise their profits gave birth to the concept of total quality management (TQM). TQM is still trendy and a great number of companies are actively implementing its rules, regulations, and procedures. However, the concept is rather complicated, culture-bound, and diverse and calls for further studies in new settings. Service section is one setting that has not received its proper attention in this regard. Therefore, we aim to examine the relationship between a group of TQM techniques called critical success factors and process improvement in service companies. To reach that end, we clustered our sample of employees based on their perceptions of TQM critical success factors and then compared the clusters’ level of process improvement. The results reveal that the level of the process improvement differs significantly between the established groups of employees. This suggests that companies’ different levels of .
Knowledge sharing motivation in e-commerce online community

The utilization of e-marketplace perceived to support users in selling their product. However, there are some difficulties faced by user in setting up the online space, utilizing the features and marketing their products. Hence, to minimize these barriers users could to share information and knowledge amongst them. Hence, the objective of this study is to identify the motivations for knowledge sharing in online community. An online community formed in Bukalapak.com an e-commerce website in Indonesia were chosen as the case study. Social exchange theory, social cognitive theory and trust were studied as the basic theories in this research. We conducted quantitative approach with 105 respondents and analyzed the data using descriptive statistic. The result showed that self-efficacy, personal outcome expectation, community related outcome expectation from social cognitive theory are the motivations in knowledge sharing. In addition, of self-worth, enjoying helping, reciprocity and social support from social exchange theory are the motivations for sharing knowledge but not applied to reputation. Information-based trust and identification were also identified as the motivations for sharing in online community.
Institutions of Deliberative Democratic Processes and Interest Groups: Roles, Tensions and Incentives

There are inherent tensions between traditional, more pluralist forms of public participation and new deliberative democratic processes, such as citizens’ juries. These innovative processes, known collectively as citizens’ forums, challenge existing roles and power relationships between interest groups and the state. Instead of having key access to the policy stage, interest groups are required to be ‘bystanders’, ‘information providers’, and ultimately ‘process legitimisers’. With such a radical shift in roles and power structure, there are few apparent reasons why interest groups would want to participate in such deliberative processes. In some cases, to the detriment of the process, they decide not to.
Time-Changed Fast Mean-Reverting Stochastic Volatility Models

We introduce a class of randomly time-changed fast mean-reverting stochastic volatility (TC-FMR-SV) models. Using spectral theory and singular perturbation techniques, we derive an approximation for the price of any European option in the TC-FMR-SV setting. Three examples of random time-changes are provided and are shown to induce distinct implied volatility surfaces. The key features of the TC-FMR-SV framework are that (i) it is able to incorporate jumps into the price process of the underlying asset (ii) it allows for the leverage effect and (iii) it can accommodate multiple factors of volatility, which operate on different time-scales.
The Effect of the 2009 Influenza Pandemic on Absence from Work

In July 2009, the World Health Organization declared the first flu pandemic in nearly 40 years. Although the health effects of the pandemic have been studied, there is little research examining the labor productivity consequences. Using unique sick leave data from the Chilean private health insurance system, we estimate the effect of the pandemic on missed days of work. We estimate that the pandemic increased mean flu days missed by 0.042 days per person-month during the 2009 peak winter months (June and July), representing an 800% increase in missed days relative to the sample mean. Calculations using the estimated effect imply a minimum 0.2% reduction in Chile's labor supply. Copyright © 2017 John Wiley & Sons, Ltd.
Hypercoagulopathy in Stroke Patients with Nonvalvular Atrial Fibrillation: Hematologic and Cardiologic Investigations

The coagulation system is activated and coagulation activation markers are elevated in acute ischemic stroke with nonvalvular atrial fibrillation (NVAF). The etiology, severity, and prognosis of the ischemic stroke might be estimated with the level of the activation of the coagulation system. In this study, prothrombin F1+2 (F1+2), D-dimer, and fibrinogen levels were measured in patients with acute ischemic stroke with and without NVAF, and stroke severity was compared with these hemostatic parameters. Of 55 patients, 29 had sinus rhythm (group I), 26 had NVAF (group II); 20 healthy subjects (group III) were included in the study. Subtypes of cerebral infarction were classified. The patients underwent stroke severity, electrocardiography, echocardiography, cranial computed tomography, cervical duplex ultrasonography, and hemostatic parameter studies. In group II, F1+2 level (2.83±0.89) was significantly higher than in group I (2.33±0.80) and III (1.94±0.64) (p values: group I-II, 0.036; groups II-III, 0.001; groups I-III, 0.104). In group III, fibrinogen level (251.64±60.96) was significantly lower than that in groups I (347.97±111.49) and II (364.04±86.20) (p=0.001). D-dimer was not significantly different between groups. In group I, lacunar syndrome (LACS), and in group II, partial and total anterior circulation syndrome (PACS+TACS) were more common (p=0.013, p=0.001, respectively). In group II, Scandinavian Stroke Scale scores were lower than those in group I (group I=45.2±14, group II=35.4±18.9, p=0.02). In conclusion, activation of coagulation, demonstrated by increment F1+2, is more abundant in the stroke patients with NVAF than in the stroke patients with sinus rhythm. Our results also showed that activation of the hemostatic system might be related to stroke subtype and stroke severity. It is suggested that the oral anticoagulation treatment as prophylaxis is important in the prevention of stroke in patients with NVAF.
Millimeter-Wave Tiny Lens Antenna Employing U-Shaped Filter Arrays for 5G

This letter presents a 28-GHz compact antenna array that employs a U-Shaped thin lens where a low-profile 1 × 4 antenna array is used as a feed source. The letter demonstrates that the proposed three-dimensional (3-D) U-Shaped lens designed by phase-shifting spatial filter arrays enables more than 3 dB peak gain enhancement even at the distance of less than half of the wavelength from the feed antenna. The first design step is to employ unit cells having a stable insertion loss and phase shift against the incident angle of electromagnetic waves without the gain degradation caused by undesired cavity effects, which is a critical bottleneck at such a short distance. In addition to this, the total gain is further enhanced by creating a novel 3-D U-Shaped architecture, enabling an increase in the effective aperture size because the U-Shaped thin lens can capture the radiated fields over a broader range of incident angles compared to the prior flat lens, which is more effective at a closer distance. This letter demonstrates that the proposed approach can achieve higher than 3.8 dB enhancement in peak gain compared to the antenna without the U-Shaped lens when the phase offset (PO) is 0°. When the levels of the PO are 45°, 90°, and 135°, gain enhancements of 3.4, 3, and 2 dB are also achieved, respectively.
Analyzed dietary intakes, plasma concentrations of zinc, copper, and selenium, and related antioxidant enzyme activities in hospitalized elderly women.

OBJECTIVE The purpose of the study was to assess the actual dietary intakes of zinc (Zn), copper (Cu) and selenium (Se) intakes in relation with some indicators of trace element status in a selected group of hospitalized elderly patients. SUBJECTS 24 elderly women aged 76-99 years were recruited in the Geriatric Department of the Grenoble University Hospital. MEASURES OF OUTCOME Zn, Cu, and Se dietary intakes were estimated by duplicate portion analysis. Plasma trace element concentrations, Cu-Zn superoxide dismutase (Cu-Zn SOD) and Se glutathione peroxidase (Se GSH-Px) activities were determined in parallel. RESULTS Mean daily intakes of Zn (5.6 mg), Cu (0.67 mg), and Se (23 micrograms) were low, in relation with poor energy intake and nutrient densities. Zn and Se levels in plasma were lower and plasma Cu increased compared to reference values obtained from healthy younger subjects. Thirty-eight percent of the elderly patients had plasma Zn concentrations < 10.7 mumol/l, but Cu status appeared adequate as suggested by the lack of decline in Cu-Zn SOD activity. A high proportion of plasma Se concentrations < 0.76 mumol/l and the parallel decrease in erythrocyte and plasma GSH-Px activities suggest a Se deficiency in this population. CONCLUSION Our findings indicate that French hospitalized elderly patients may be at risk of Zn and Se marginal status and present altered antioxidant defenses in relation with low dietary intakes. It underlines the interest of supplementation studies in this population.
The Depletion Allowance and Vertical Integration in the Petroleum Industry

The Hay Model of vertical integration is applied to the petroleum industry to test the conventional belief that additional cash flow from increased crude production will offset any losses from downstream operations. By contrast, the model results show that the combined effects of an income tax and depletion allowance are enough to motivate downstream integration. Even though fixed coefficients do not allow economies of factor substitution, vertical integration can be prompted by the fact that cash flow from income tax deductions may be increased by increasing the crude oil posted price. The model not only shows that downstream losses may be a rational reaction to a depletion allowance, but it also predicts that integration will be less viable without depletion. 11 references.
Elections as Levers of Democracy: A Global Inquiry

In this paper we purport to test the proposition that elections have a democratizing effect, drawing on cross-sectional time-series data at best covering a global sample of 193 countries from 1919 to 2004. Two versions of this proposition are tested: one with respect to current effects, another with respect to cumulative effects. The first maintains that the holding of an election would yield democratizing gains more or less immediately, either in the time period following shortly after the election or in the non-electoral spheres of society. The second version instead holds that the historical experience with a prolonged series of elections in the end would yield a democratizing effect. In our tests, we find support for both proposals⎯at least for certain ways of measuring the effects in question. Current effects manifest themselves primarily in the immediate aftermath of multiparty elections. We can also observe improvements in the no-electoral realm (with respect to civil liberties), but this effect is marred with uncertainty regarding the validity of the data at hand. As for the cumulative proposal, we conclude that the number of multiparty—or, even more strongly, free and fair—elections, which a country has experienced, has democratic influence, primarily on the non-electoral sphere of democracy. At the same time, the effect is not very strong and the relative influence of every new election is declining. Jan Teorell Department of Political Science, Lund University jan.teorell@svet.lu. se Axel Hadenius Department of Political Science Lund University axel.hadenius@svet.lu. se
Reinventing management purpose: the radical and virtuous alternatives

Purpose – One of the lessons of the Great Recession is that managing for shareholder value can result in damage to other stakeholders. This paper seeks to articulate a new purpose for the firm that is more legitimate than maximizing financial returns for shareholders.Design/methodology/approach – The paper examines the various management alternatives: modify the shareholder value strategy; become socially responsible; and adopt radical management practices.Findings – A central question is whether the alternative management models will contribute to corporate longevity. The paper suggests an alternative approach: the virtuous corporate.Originality/value – The paper looks at the virtuous corporation which would balance the need to reward external stakeholders with relentless attention to internal excellence and virtue.
A Life-Cycle Model of Locational Choice in a Two-Region Economy

The ability to use the amenities or other characteristics of a location may be a function of the length of time a household has resided in the location. We explore the implications of the hypothesis that the enjoyment of regional amenities depends on the accumulation of amenity-specific human capital. We establish that the interaction of this human capital with regional wage rates determines life-cycle locational trajectories. The model explains the timing of moves in the working and retirement periods of life as well as observed heterogeneity in household behavior. Small differences between households may result in dramatically different life-cycle behavior.
The cutting mechanism

1 l unning athletes change direction by the mechanism known as cutting. Actually, mechanisms for change of direction exist for standing, walking, or running. In this paper we deal only with the cutting mechanism as it applies to running gait, because this represents the most hazardous situation for the ligaments of the knee. Inman et al.1 have defined the human walking gait well. Significant differences between the walking gait and the running gait were described by Slocum and Bowerman.2 Although the specifics of running gait differ among various sports, James and Brubaker3 have provided a good general working definition. Two phases of running gait have been described: the support phase and the recovery phase. Furthermore, each phase has been divided into three periods. The support phase consists of foot strike, midsupport, and takeoff, and the recovery phase consists of follow through, forward swing, and foot descent. A &dquo;float&dquo; section has been described for normal
The Timescale Effects of Corporate Governance Measure on Predicting Financial Distress

This study aims to investigate the timescale effects of the corporate governance measure on predicting financial distress of corporations. A new corporate governance measure is adopted in the logistic regression model. Historical data of the companies listed on the Taiwan Stock Exchange Corporation (TSEC) were used in the empirical analysis. The analysis was based on three different prediction horizons comprising one-, two- and three-year horizons. The results confirmed that the accuracy of the logistic regression model for predicting corporate financial distress can be improved by incorporating the corporate governance measure. Moreover, the improvements of the correct rate for classification by incorporating the corporate governance measure increased as the prediction horizon was raised. The improvements of the correct rate for classification by incorporating the corporate governance measure are 2.9%, 4.4% and 5.8% for "Year 1", "Year 2" and "Year 3" models respectively.
Prokinetic Effects of Erythromycin after Antimotion Sickness Drugs

Motion sickness and the antimotion sickness drugs scopolamine (SCP) and promethazine (PMZ) inhibit gastric emptying (GE). This study was conducted to determine if erythromycin would exert its well‐known prokinetic effects in normal and motion‐sick subjects given antimotion sickness drugs. Fifteen fasted volunteers (11 males, 4 females) participated in the study In control tests, 8 subjects were given intramuscular (IM) saline (SAL, 0.5 ml), SCP (0.1 mg), or PMZ (25 mg). GE of liquid (300 ml) containing 1 mCi of Tc 99m diethylenetria‐minepentaacetic acid (DTPA) was measured by sequential gastric scintigraphy 30 minutes after IM treatments. In other tests, GE was measured in 8 subjects after each IM treatment, followed 10 minutes later by 200 mg of erythromycin thylsuccinate (ESS) suspension given orally. In a third group of tests, 7 subjects received an IM treatment, oral EES 10 minutes later, and were then brought to an advanced level of motion sickness short of vomiting. To induce motion sickness, blindfolded subjects made timed head movements while seated in a rotating chair. GE was measured immediately after rotation. GE half‐life, rate constant, area under the curve (AUC), and lag time were calculated using conventional mathematical methods for analyzing exponential rate processes. GE parameters calculated for normal and motion‐sick subjects given antimotion sickness drugs and EES were compared with those from subjects given IM treatments (control) only. In normal subjects, EES significantly (p < 0.05) increased the GE rate constant for all IM treatments and reduced the AUC for SAL, SCP, and PMZ by 49% (p < 0.05), 44% (p < 0.05), and 69% (p < 0.01), respectively. In motion‐sick subjects, lag time was significantly (p < 0.05) increased, and the rate constant and AUC values were unchanged from control for all IM treatments. The authors conclude that oral EES reverses the gastrostatic actions of the antimotion sickness drugs but does not affect the inhibition of gastric emptying associated with motion sickness. The results suggest that motion sickness and antimotion sickness drugs reduce GE through different mechanisms.
Using floor plan to calibrate sensor error for indoor localization

Some prior studies proposed the use of Pedestrian Dead Reckoning (PDR) for indoor localization, in which a small number of inertial sensors are put on the pedestrian. These sensors (such as a G-sensor and gyroscope) are used to estimate the distance and direction that a user travels. The effectiveness of a PDR system lies in its success in accurately estimating the user's moving distance and direction. In this work, we design a map matching algorithm to calibrate the sensor errors using building floor plans. The results of our experiment show that we can achieve an overall location error of about 0.48 meter.
Differences between Inequalities and Unequal Exchange: Comments on the Papers by Chaves and Köhler

Kohler's critique of global wages, where he presents the concept of productivity with great clarity, combines very well with Chaves' presentation of Kohler's model of Unequal Exchange (UE). A brief and solid common position emerges. As I wrote that "the dimension of non-equivalence in a strict, logical sense" can only be shown by comparing real wages, I fully second Kohler's use of Purchase Power Parity (PPP)-data. In the 1980s, I explicitly referred to the research on PPP comparisons. Therefore I am glad he taps the progress made by PPP-research. Nevertheless, Kohler's model does not explain UE.