Miracle-dz/UniFAR-FTUs huggingface dataset:
Prolonged duration of post-traumatic amnesia: A sensitive classification for predicting cognitive outcomes in children recovering from traumatic brain injury

Abstract Objective: A paucity of data exists regarding the duration of post-traumatic amnesia (PTA) as a predictor of cognitive functioning among children after traumatic brain injury (TBI). The study aimed to assess the relationship between PTA duration and areas of neurocognitive function among the pediatric population in the sub-acute phase of recovery and rehabilitation. Methods: Data were collected from medical files on 103 children aged 5.5–16.5 hospitalized at a pediatric rehabilitation department with a diagnosis of moderate–severe TBI (msTBI) between the years 2004–2019. The Children Orientation and Amnesia Test was used to evaluate PTA duration. Measures of high-order cognitive abilities of attention and executive function were collected using the Test of Everyday Attention–Child version (TEA-Ch). Results: Three PTA duration groups were assembled out of a cluster analysis: “Long PTA” (M = 21 days), “Very Long PTA” (M = 47 days), and “Extremely Long PTA” (M = 94 days). Analyses revealed that the “Long PTA” group preformed significantly better than the “Very Long PTA” and “Extremely Long PTA” groups on all TEA-Ch measures, that is, Selective Attention, Attentional Control Switching, and Sustained Attention. Conclusions: This study is the first to demonstrate that PTA duration is a useful predictor of high-order cognitive functions among children with msTBI in the sub-acute phase of recovery and rehabilitation. The findings emphasize the importance of using a more sensitive classification of prolonged PTA durations to improve outcome prediction and allocation of resources to those who can benefit most after severe brain injuries.
Division and bit-serial multiplication over GF(qm)

Division and bit-serial multiplication in finite fields are considered. Using co-ordinates of the supporting elements it is shown that, when field elements are represented by polynomials, division over GF(qm) can be performed by solving a system of m linear equations over GF(q). For a canonical basis representation, a relationship between the division and the discrete-time Wiener-Hopf equation of degree m over GF(q) is derived. This relationship leads to a bit-serial multiplication scheme that can be easily realised for all irreducible polynomials.
Algol - CPNG: photon counting cameras for interferometry in visible wavelengths

Images in visible interferometry are characterised by their low coherence time, and except for brightest stars, the flux on the detector is much less than one photon per pixel per image. Algol and Comptage de Photons Nouvelle Generation (CPNG) are new photon counting cameras developed for high angular resolution in the visible. They are intensified CCDs built to benefit from improvements in photonic commercial components, and personal computer processing power. We present how we achieve optimal performances (sensitivity and spatiotemporal resolution) by the combination of proper optical and electronics design, and real-time elaborated data processing. The number of pixels is 532 × 516 and 768 × 640 read at a frame rate of 262 Hz and 50 Hz for CPNG and Algol respectively. The dark current is very low: 5 × 10 -4 electron.pixel -1 . s -1 . Quantum efficiencies reach up to 36% in the visible with the GaAsP photocathodes and and 26% in the red with the GaAs ones, thanks to the sensitivity of the photocathodes and to the photon centroiding algorithm; they are likely the highest values reported for ICCDs.
Bridging the gap between weather and seasonal forecasting: intraseasonal forecasting for Australia

This study examines the potential use of the Predictive Ocean Atmosphere Model for Australia (POAMA), the Bureau of Meteorology's dynamical seasonal forecast system, as an intraseasonal prediction tool for Australia. This would fill the current prediction capability gap between weather forecasts and seasonal outlooks for Australia. The intraseasonal forecast skill of a 27‐year hindcast dataset is investigated, focusing on precipitation and minimum and maximum temperatures over Australia in the second fortnight (average days 15–28 of the forecast). Most of the skill for forecasting precipitation and maximum temperature in the second fortnight is focused over eastern Australia, during austral winter and spring for precipitation and during spring for maximum temperature. For this region and seasons the forecast of the second fortnight performs generally better than using climatology, persistence of observed, or persistence of the forecast for the first fortnight (average days 1–14). The model has generally poor skill in predicting minimum temperatures. The role of key drivers of Australian climate variability for providing predictability at intraseasonal time‐scales is investigated. This is done for the austral winter and spring seasons, when POAMA's skill for predicting precipitation is highest. Forecast skill is found to be increased during extremes of the El Niño Southern Oscillation, the Indian Ocean Dipole and the Southern Annular Mode. The regions of impact of these modes of climate variability on forecast skill are similar to those regions identified in observed studies as being influenced by the respective drivers. In contrast, there is no significant relationship between intraseasonal forecast skill for precipitation and the amplitude of the Madden Julian Oscillation (MJO) in winter and spring, although the analysis does not distinguish between the phases of the MJO. The results indicate that the use of POAMA for intraseasonal forecasting is promising. Copyright © 2011 Royal Meteorological Society
Machine Learning-Guided Computational Screening of New Candidate Reactions with High Bioorthogonal Click Potential.

Bioorthogonal click chemistry has become an indispensable part of the biochemist's toolbox. Despite the wide variety of applications that have been developed in recent years, only a limited number of bioorthogonal click reactions have been discovered so far, most of them based on (substituted) azides. In this work, we present a computational workflow to discover new candidate reactions with promising kinetic and thermodynamic properties for bioorthogonal click applications. Sampling only around 0.05% of an overall search space of over 10,000,000 dipolar cycloadditions, we develop a machine learning model able to predict DFT-computed activation and reaction energies within ~2-3 kcal/mol across the entire space. Applying this model to screen the full search space through iterative rounds of learning, we identify a broad pool of candidate reactions with rich structural diversity, which can be used as a starting point or source of inspiration for future experimental development of both azide-based and non-azide-based bioorthogonal click reactions.
Identifying methods to best integrate indigenous knowledge and perspectives within the radiation therapy undergraduate curriculum

The Australian healthcare system continues to work towards close the gap to improve and achieve equality in health and life expectancy for Aboriginal and Torres Strait Islander peoples. When culturally safe practice is forefront, it may be the driving force in improving Indigenous Australian healthcare outcomes. For students and practitioners to be equipped with the industry‐required cultural safety skills, we believe Indigenous Australian knowledge and perspectives must be effectively integrated into undergraduate education. A scoping review of the literature was conducted to identify the most effective teaching and learning methods and assessment tools to best integrate Indigenous knowledge and perspectives into undergraduate radiation therapy curriculum at Queensland University of Technology (QUT). Embase, CINAHL, Scopus and PubMed‐Medline were searched to access peer‐reviewed studies published between 2017 and 2022. A total of 591 articles were identified with 39 full‐text articles meeting the inclusion criteria. Methods of teaching and learning and independent assessment tools that promote cultural capability in undergraduate education were identified. Findings included intensive patient‐specific workshops, which were reported to provide students with an immersive learning experience, better preparing them for clinical placements and future practice. Additionally, other allied healthcare professions have utilised tools such as the Cultural Capability Management Tool (CCMT) and Trans‐Cultural Self‐Efficacy Tool (TSET) to quantitatively assess positive shifts and highlight developmental needs. These findings will inform current educational endeavours to promote cultural safety and the cultural capability continuum in the undergraduate radiation therapy curriculum.
Trivalent mosaic or consensus HIV immunogens prime humoral and broader cellular immune responses in adults

BACKGROUND Mosaic and consensus HIV-1 immunogens provide two distinct approaches to elicit greater breadth of coverage against globally circulating HIV-1 and have shown improved immunologic breadth in nonhuman primate models. METHODS This double-blind randomized trial enrolled 105 healthy HIV-uninfected adults who received 3 doses of either a trivalent global mosaic, a group M consensus (CON-S), or a natural clade B (Nat-B) gp160 env DNA vaccine followed by 2 doses of a heterologous modified vaccinia Ankara–vectored HIV-1 vaccine or placebo. We performed prespecified blinded immunogenicity analyses at day 70 and day 238 after the first immunization. T cell responses to vaccine antigens and 5 heterologous Env variants were fully mapped. RESULTS Env-specific CD4+ T cell responses were induced in 71% of the mosaic vaccine recipients versus 48% of the CON-S recipients and 48% of the natural Env recipients. The mean number of T cell epitopes recognized was 2.5 (95% CI, 1.2–4.2) for mosaic recipients, 1.6 (95% CI, 0.82–2.6) for CON-S recipients, and 1.1 (95% CI, 0.62–1.71) for Nat-B recipients. Mean breadth was significantly greater in the mosaic group than in the Nat-B group using overall (P = 0.014), prime-matched (P = 0.002), heterologous (P = 0.046), and boost-matched (P = 0.009) measures. Overall T cell breadth was largely due to Env-specific CD4+ T cell responses. CONCLUSION Priming with a mosaic antigen significantly increased the number of epitopes recognized by Env-specific T cells and enabled more, albeit still limited, cross-recognition of heterologous variants. Mosaic and consensus immunogens are promising approaches to address global diversity of HIV-1. TRIAL REGISTRATION ClinicalTrials.gov NCT02296541. FUNDING US NIH grants UM1 AI068614, UM1 AI068635, UM1 AI068618, UM1 AI069412, UL1 RR025758, P30 AI064518, UM1 AI100645, and UM1 AI144371, and Bill & Melinda Gates Foundation grant OPP52282.
Comparison of InAs/GaAs Quantum Dot Infrared Photodetector and GaAs/(AlGa)As Superlattice Infrared Photodetector

A 10-stacked InAs/GaAs quantum dot infrared photodetector (QDIP) is compared with a 20-period GaAs/(AlGa)As superlattice infrared photodetector (SLIP). The 2–10 µm wide detection window and 187 mA/W high peak responsivity of InAs/GaAs QDIP at 7 µm at an applied voltage of 1.1 V are superior to the 7–10 µm detection window and 140 mA/W responsivity of GaAs/(AlGa)As SLIP at 9.4 µm at an applied voltage of 1.3 V. The photocurrent of SLIP is temperature-independent, whereas the photocurrent of QDIP increases with increasing temperature from 20 to 100 K. The polarization-dependent response ratios of 0.22 and 0.39 are observed for SLIP and QDIP, respectively.
Chemical characterization of combustion engine exhaust and assessment of helicopter deck operator occupational exposures on an offshore frigate class ship

Abstract Diesel engine exhaust (DE) consists of a complex mixture of gases and aerosols, originating from sources such as engines, turbines, and power generators. It is composed of a wide range of toxic compounds ranging from constituents that are irritating to those that are carcinogenic. The purposes of this work were to characterize DE originating from different engine types on a ship operating offshore and to quantify the potential exposure of workers on the ship’s helicopter deck to select DE compounds. Sampling was conducted on a Norwegian Nansen-class frigate that included helicopter operations. Frigate engines and generators were fueled by marine diesel oil, while the helicopter engine was fueled by high flash point kerosene-type aviation fuel. Exhaust samples were collected directly from the stack of the diesel engine and one of the diesel generator exhaust stacks, inside a gas turbine exhaust stack, and at the exhaust outlet of the helicopter. To characterize the different exhaust sources, non-targeted screening of volatile and semi-volatile organic compounds was performed for multiple chemical classes. Some of the compounds detected at the sources are known irritants, such as phthalic anhydride, 2,5-dyphenyl-p-benzoquinone, styrene, cinnoline, and phenyl maleic anhydride. The exhaust from the diesel engine and diesel generator was found to contain the highest amounts of particulate matter and gaseous compounds, while the gas turbine had the lowest emissions. Personal exposure samples were collected outdoors in the breathing zone of a helicopter deck operator over nine working shifts, simultaneously with stationary measurements on the helicopter deck. Elemental carbon, nitrogen dioxide, and several volatile organic compounds are known to be present in DE, such as formaldehyde, acrolein, and phenol were specifically targeted. Measured DE exposures of the crew on the helicopter deck were variable, but less than the current European occupational exposure limits for all compounds, except elemental carbon, in which concentration varied between 0.5 and 37 µg/m3 over nine work shifts. These findings are among the first published for this type of working environment.
Biological Variabilityin Concentrations of SerumLipids:Sourcesof Variationamong ResultsfromPublishedStudiesand CompositePredictedValues1

characteristics of the study-primarily the number of subjects, the sampling interval, and the numberof measurementsper subject. For TC, we founda statistically significant positive correlation betweenthe reportedmean CVb and both the number of study subjects and the analytical variation.ForTC and LDLCwe estimateCVbas a function of the study design features. The number of patient specimens requiredto obtain reliable estimates for serumlipidconcentrationsare determined fromthe CVb
Further refining the boundaries of the hippocampus CA2 with gene expression and connectivity: Potential subregions and heterogeneous cell types

Over the last two decades, the definition of hippocampal area CA2 has evolved from Lorente de Nó's original Golgi‐based morphological description with the discovery of specific CA2 gene expression markers. Exploiting the specificity of these molecules has allowed for the genetic dissection of CA2 structure and function in transgenic mice. With this change in criteria, the anatomical boundaries of the CA2 have expanded across the hippocampal axis but the CA2's full rostrocaudal extent is not consistently delineated across atlases. The Hippocampus Gene Expression Atlas (HGEA) provides a comprehensive map of 20 gene expression domains across the entire mouse hippocampus including the CA2. In this commentary, I will review the consensus gene expression patterns that demarcate the expanded CA2 boundaries in the HGEA. Using DropViz single‐cell transcriptomics and Mouse Connectome Project connectomics data, I will then suggest potential differences in CA2 cell type heterogeneity and connectivity that may identify and characterize further CA2 subregions.
Evolutionary analysis of a complete chicken genome

Significance Chicken is one of the most important vertebrate model organisms, yet its genome is far from complete. This study generated the complete sequence of a chicken genome, uncovering six chromosome models absent in previous genome assemblies. Ten small microchromosomes evolved distinct genomic and epigenetic features, unlike any other vertebrate chromosomes but remain stable and conserved in birds. Most chicken centromeres were found to contain higher-order repeats (HORs), resembling the centromeric organization in primates. The complete chicken chromosome models are useful to reconstruct the karyotype of the vertebrate ancestor. We reveal the evolutionary trajectory of chromosome changes from ancestral chordate to early vertebrate and Amniota through frequent fusion events before and after whole-genome duplications.
Safety and Efficacy of Moderately-High Dose Turmacin® (Turmerosaccharide >10% w/w) Supplementation on Joint Discomfort in Healthy Adults - A Pilot Proof-of-Concept Single Arm Study

Abstract Turmeric is well-known for its analgesic, anti-inflammatory and anti-arthritic properties but 69.4% of the turmeric rhizome contains Turmerosaccharides whose clinical benefit is still unexplored. Turmacin®/NR-INF-02 is an aqueous extract of Turmeric containing Turmerosaccharides (>10%w/w) with negligible curcuminoids. Previous study with low dose Turmacin® confirmed its safety and efficacy in alleviating induced knee pain in healthy volunteers. Hence, this study aimed to assess the safety and explore the efficacy of moderately high dose Turmacin®. It was an open-label, single-arm interventional trial conducted from August 2018 – January 2019 in a tertiary care teaching hospital. Turmacin® was administered for seven days to 15 healthy volunteers as four capsules of 500 mg each in the morning with food. The stair mill at a speed of 60 steps per minute was used to induce knee pain and Visual Analogue Scale (VAS) was used to measure the pain intensity. Assessments were performed at baseline, Days 5 and 7. One participant reported dyspepsia of mild grade that resolved on its own. When compared to baseline, time to initial discomfort significantly increased on Day-5 (Mean Difference [MD] = 30s, p = 0.016) and Day-7 (MD = 32s, p = 0.007). Whereas the maximum VAS score decreased with time and on Day-7 and it was significantly low when compared with baseline (MD = −0.93, p = 0.008). In summary, Turmacin® supplements given at a dose of 2 g/day was safe and tolerable. Similar to the previous study with low dose Turmacin®, there was a significant increase in pain threshold and decrease in the maximum pain score post intervention.
Mindfulness and burnout among Chinese college students: mediation through sleep quality and perceived stress

ABSTRACT College students often face challenges and obstacles which leads them vulnerable to burnout. Though numerous studies have supported an association between mindfulness and burnout, yet little is known about the potential mediating role of mindfulness exerts its effect in this link. This study aimed to explore the relationship between mindfulness and burnout among Chinese college students and investigated the sleep quality and perceived stress as two potential mediators of that relationship. A total of 536 college students (mean age = 21.93, 66.2% female) were investigated and completed the Five Facet of Mindfulness Questionnaire, Pittsburgh Sleep Quality Index, Perceived Stress Scale and Academic Burnout Scale of College Students. Path analyses were employed to examine the mediating effect. Results indicated that mindfulness had significant negative correlation with burnout (r=−.584, p < 0.001). Sleep quality and perceived stress were significant mediators of the observed relationship between mindfulness and burnout. These findings shed light upon the mediating role of sleep quality and perceived stress, and suggest that college students’ mindfulness may facilitate their sleep quality and decrease perceived stress, which, in turn, may help prevent and reduce burnout.
The effectiveness of botulinum toxin for chronic tension-type headache prophylaxis: A systematic review and meta-analysis

Background A systematic and meta-analysis was conducted to examine the evidence of the effects of botulinum toxin A on chronic tension-type headache. Methods Cochrane, Embase, Ovid, ProQuest, PubMed, Scopus, Web-of-Science databases, and ClinicallTrials.gov registry were systematically searched for studies examining the effects of botulinum toxin A on tension-type headaches. The records were screened by two independent reviewers using pre-determined eligibility criteria. DerSimonian Liard random-effects meta-analyses were performed using the ‘meta’ package (5.2-0) in R (4.2.0). Risk of bias and quality of evidence were assessed using the Cochrane Collaboration’s Tool RoB 2 and Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methodology. Clinical significance was determined using pre-defined minimal clinically important differences. Results Eleven controlled trials were included (390 botulinum toxin A, 297 controls). Botulinum toxin A was associated with significant improvements in standardized headache intensity (−0.502 standard deviations [−0.945, −0.058]), headache frequency (−2.830 days/month [−4.082, −1.578]), daily headache duration (−0.965 [−1.860, −0.069]) and the frequency of acute pain medication use (−2.200 days/month [−3.485, −0.915]) vs controls. Botulinum toxin A-associated improvements exceeded minimal clinically important differences for headache intensity, frequency, and acute pain medication use. A 79% (28%, 150%) greater response rate was observed for botulinum toxin A vs controls in improving chronic tension-type headache. Treatment of eight chronic tension-type headache patients was sufficient to elicit a therapeutic response in one patient. Conclusions Corroborating the current mechanistic evidence, our meta-analysis supports the utility of botulinum toxin A for managing chronic tension-type headaches. However, due to limitations in the quality of evidence, adequately-powered high-quality controlled trials examining the effects of Botulinum toxin A on chronic tension-type headache are warranted. Registration Protocol preregistered in PROSPERO International Prospective Register of Systematic Reviews (CRD42020178616)
Bibliometric analysis of the literature on von Willebrand disease: research status and trends

Background and aim: Von Willebrand disease (VWD) is considered the most prevalent inherited bleeding disorder. The current study aims to demonstrate the research status and trends on VWD worldwide. Methods: Bibliometric analysis was used to investigate the global research productivity and trends on VWD. The publications on VWD from 1956 to 2021 were extracted using the Web of Science database. In the VWD domain, a total of 3,643 records were analyzed for authorship and collaboration patterns, yearly productivity, highly cited documents, relevant source of publication, most prolific scholars, productive countries, and organizations. Results: The most productive journal, author, organization, and country were ‘Haemophilia’ with 439 publications, ‘Favaloro EJ’ with 119 publications, the ‘University of Milan’ with 192 publications, and the United States of America (USA) with 1,048 publications, respectively. The document with the highest citations was ‘Srivastava A, 2013, Haemophilia,’ which received 1,154 citations in total. In 2016, the highest number of publications shared by two author patterns was 28. With 199 publications, the year 2021 remained on the top, while the citation-wise analysis identified 2006 as the top year with 5,379 citations. Conclusions: Research productivity and publication trends on VWD revealed that the USA emerged as the most significant contributing country. The ‘University of Milan’ was the most significant contributing organization, while ‘Favaloro EJ’ was the most significant author. ‘Hemophilia’ was found to be the most significant journal in the field of VWD. It is recommended that researchers from countries with significant contributions to the field should collaborate with researchers from Asian countries and other countries that lack behind in research in the domain of VWD. (www.actabiomedica.it)