Miracle-dz/UniFAR-FTUs huggingface dataset:
Quality-adjusted survival analysis of first-line treatment of hormone-receptor-positive HER2+ metastatic breast cancer with letrozole alone or in combination with lapatinib

Abstract Aim: Compare first-line lapatinib plus letrozole (L + Let) versus letrozole monotherapy (Let) in hormone-receptor-positive HER2 + metastatic breast cancer, employing Q-TWiST (quality-adjusted time without symptoms and toxicity) analysis to account for differences in progression times, with offsets for the impact of adverse events during the treatment period. Methods: The area under survival curves for each treatment group was partitioned into distinct health states of varying utility: toxicity (TOX), time without toxicity or disease progression (TWiST), and the period following disease progression until death or end of follow-up (REL). The utility-weighted sum of the mean health state durations was derived for each group. The threshold utility analysis evaluates how varying utility values across the states affects Q-TWiST differences between groups, although the method is limited by not varying utilities within each health state. Results: The primary analysis population was the HER2 + subgroup (n = 219). There was no significant difference between treatments in mean duration of grade 3/4 adverse events prior to progression (L + Let = 1.95 weeks; Let = 2.14 weeks; P = 0.90). Using utility weights of 0.5 for TOX and REL, L + Let was favored for quality-adjusted survival by 8.8 weeks (P = 0.09). The Q-TWiST difference between treatment groups ranged from 8 to 9.5 weeks, favoring combination therapy for all hypothetical utility levels, but none of the comparisons were statistically significant at P = 0.05. Conclusions: No significant differences were found between L + Let versus Let in mean duration of severe adverse events. Quality-adjusted survival was favored for the combination treatment arm for all utility levels examined when toxicity was defined by grade 3/4 AEs, but differences between groups were not statistically significant. Trial registration: ClinicalTrials.gov identifier: NCT00073528.
Equational incompleteness and incomparability results for lambda calculus functional semantics

In this paper we establish the existence of a lambda theory which can be modeled in continuous semantics but neither in stable nor hypercoherent semantics. That give us a new equational incompleteness result for the stable semantics and the first one for a strongly stable semantics. We deduce the firsts equational incomparability theorems for untyped lambda calculus semantics.
Environments, Adolescents’ Aspirations and Young Adults’ Status Attainment

Summary Regression surface analysis was used to examine relationships among adolescents’ perceptions of parents’ support for learning, adolescents’ aspirations and their status attainment as young adults. The young adults were classifed into four family groups, defined conjointly by family social status and by early family socialisation practices. Longitudinal data were collected from 334 Australians who were 11‐, 16‐ and 21‐years‐old during three surveys. Regression models which included terms to test for linear, interaction and curvilinear associations among the variables were examined within each family group. The results suggested that children's family environments may be considered to act as critical underlying contexts for the formation of adolescents’ perceptions and aspirations of young adults’ status attainment.
New Institutionalism: Distilling Some ‘Hard Core’ Propositions in the Works of Williamson and March and Olsen

The efflorescence of work on new institutionalism has encouraged scholars to build bridges between various schools of thought. Such cross-fertilisation enlivens the debate but runs the risk of erecting bridges on shaky foundations. My article seeks to minimise this risk by going back to basics. It narrows the field of inquiry to the economic and the sociological institutionalist tradition represented by Williamson on one side, and the collaborative work of March and Olsen on the other. It explores and assesses their contribution on three interrelated issues fundamental to any analysis of political institutions: the goals attributed to institutions, the theory of action and the commitment to methodological individualism versus methodological holism. I conclude by noting that in the transition from the old to the new institutionalism - as represented in the works of these authors - the role of power conflicts, negotiations and bargaining between individuals seems to have lost its central position.
Minimal or Massive? The Political Agenda-Setting Power of the Mass Media According to Different Methods

The debate on the media’s agenda-setting power is not settled yet. Most empirical agenda-setting studies using time-series analyses found that the media matter for the political agenda, but the size of the found media effects remains often modest. This nuanced view on media impact seems to contradict with the perceptions of politicians. Our comparative survey of members of parliament in four small parliamentary democracies—Belgium, Netherlands, Sweden, and Denmark—shows that they consider the mass media to be one of the key political agenda setters directly competing with the Prime Minister and the powerful political parties. This article further explores the inconsistency between “objective” and “subjective” findings.We develop six possible explanations for the contradicting findings produced by both methods and formulate concrete suggestions to improve both methods and diminish the gap between them.
The prevalence of co-witnesses and co-witness discussions in real eyewitnesses

Abstract Several laboratory studies have shown that eyewitness discussions can negatively affect memory recall. The current study looked at the prevalence of multiple witnesses using real witnesses at a UK identification suite. We investigated the frequency of co-witness discussion, what the co-witnesses tended to discuss and whether there was an association between this information, and the outcome of the identification. Sixty witnesses at the Force Identification Unit in Brighton (UK) filled out a questionnaire following the identification procedure. Co-witnesses were reported by 88% of the sample, with the average number of co-witnesses being 4.02 (SD=6.52). In addition, 58% of the multiple witnesses had discussed the criminal event with at least one co-witness. The most common areas of discussion were ‘general crime details’ (52%) and ‘suspect details’ (39%). The implications of these findings are discussed.
Prospective study of bacterial infection in acute liver failure: An analysis of fifty patients

Fifty consecutive patients admitted with acute liver failure, minimal grade II encephalopathy, were studied prospectively to determine to incidence, timing and cause of bacterial infection, the relationship to clinical criterial for infection; and the influence of early microbiological diagnosis on clinical outcome. There were 53 proven bacterial infections in 40 patients, whereas in 5 of the remaining 10 patients infection was suspected on clinical grounds in the absence of significant cultures. Seven patients (14%) had more than one bacterial infection, and four patients had simultaneous infections caused by different organism at each site. Fourteen infections (26.4%) were associated with backteremia, and in six of these no source was found. Twenty‐five infections (47.1%) arose from the respiratoory tract, 12 (22.6%) from the urinary tract and 2 (3.7%) from central venous due to gram‐positive bacteria; Staphylococcus aureus accounted for 19 (35.8%) of all the infections.
Regulation of MntH by a Dual Mn(II)- and Fe(II)-Dependent Transcriptional Repressor (DR2539) in Deinococcus radiodurans

The high intracellular Mn/Fe ratio observed within the bacteria Deinococcus radiodurans may contribute to its remarkable resistance to environmental stresses. We isolated DR2539, a novel regulator of intracellular Mn/Fe homeostasis in D. radiodurans. Electrophoretic gel mobility shift assays (EMSAs) revealed that DR2539 binds specifically to the promoter of the manganese acquisition transporter (MntH) gene, and that DR0865, the only Fur homologue in D. radiodurans, cannot bind to the promoter of mntH, but it can bind to the promoter of another manganese acquisition transporter, MntABC. β-galactosidase expression analysis indicated that DR2539 acts as a manganese- and iron-dependent transcriptional repressor. Further sequence alignment analysis revealed that DR2539 has evolved some special characteristics. Site-directed mutagenesis suggested that His98 plays an important role in the activities of DR2539, and further protein-DNA binding activity assays showed that the activity of H98Y mutants decreased dramatically relative to wild type DR2539. Our study suggests that D. radiodurans has evolved a very efficient manganese regulation mechanism that involves its high intracellular Mn/Fe ratio and permits resistance to extreme conditions.
Identification of Functional Human Splenic Memory B Cells by Expression of CD148 and CD27

Memory B cells isolated from human tonsils are characterized by an activated cell surface phenotype, localization to mucosal epithelium, expression of somatically mutated immunoglobulin (Ig) variable (V) region genes, and a preferential differentiation into plasma cells in vitro. In spleens of both humans and rodents, a subset of memory B cells is believed to reside in the marginal zone of the white pulp. Similar to tonsil-derived memory B cells, splenic marginal zone B cells can be distinguished from naive follicular B cells by a distinct cell surface phenotype and by the presence of somatic mutations in their Ig V region genes. Although differences exist between human naive and memory B cells, no cell surface molecules have been identified that positively identify all memory B cells. In this study, we have examined the expression of the receptor-type protein tyrosine phosphatase CD148 on human B cells. CD148+ B cells present in human spleen exhibited characteristics typical of memory B cells. These included an activated phenotype, localization to the marginal zone, the expression of somatically mutated Ig V region genes, and the preferential differentiation into plasma cells. In contrast, CD148− B cells appeared to be naive B cells due to localization to the mantle zone, the expression of surface antigens typical of unstimulated B cells, and the expression of unmutated Ig V region genes. Interestingly, CD148+ B cells also coexpressed CD27, whereas CD148− B cells were CD27−. These results identify CD148 and CD27 as markers which positively identify memory B cells present in human spleen. Thus, assessing expression of these molecules may be a convenient way to monitor the development of memory B cell responses in immunocompromised individuals or in vaccine trials.
Effect of supine and prone positions on arterial oxygen tension in the preterm infant.

To determine the optimal position for the preterm infant, arterial oxygen tension (Pao2) was monitored in 16 preterm infants by the transcutaneous method with the infants in both supine and prone positions. When the infants were prone, Pao2 rose by a mean of 7.4 mm Hg (P less than .001), an increase of 15%. In those infants with residual cardiopulmonary disease a 25% increase was noted. The higher Pao2 in the prone position was accompanied by a significant decrease in the amount of time the chest wall moved asynchronously. This improved oxygenation in the prone position appears to be the result of enhanced ventilation/perfusion ratios and not merely secondary to an alteration in sleep state with positioning of the infant. These findings may have important implications in the management of preterm infants, requiring neonatal intensive care.
Selective activation of ON and OFF retinal ganglion cells to high-frequency electrical stimulation: A computational modeling study

In this study, ON and OFF retinal ganglion cell (RGC) models based on accurate biophysics and realistic representations of cell morphologies were used to understand how these cells selectively respond to high-frequency electrical stimulation (HFS). With optimized model parameters and the incorporation of detailed cell morphologies, these two models were able to closely replicate experimental ON and OFF RGC responses to epiretinal electrical stimulation. This modeling approach can be used to design electrical stimulus profiles capable of cell-specific activation, and is broadly applicable for the development of sophisticated stimulation strategies for visual prostheses.
Structured content analysis in leadership research: a new method for international contexts

Purpose – The purpose of this paper is to evaluate structured content analysis (SCA) in leadership research by examining and contrasting it with traditional content analysis (TCA) and case survey methodology. SCA is presented as a variation of TCA, and is characterized as one that is more likely to be used by leadership researchers because of its more quantitative bent than TCA, but yet does not lose its capability to investigate inherently qualitative processes of leadership.Design/methodology/approach – The paper systematically compares features of SCA as proposed by the seminal authors to the more sophisticated SCA proposed here. This is accomplished by clarifying and strengthening some of the inadequacies of SCA as initially conceptualized. The new SCA is first described in terms of its components and typical procedures. Using relevant leadership literature, the paper: clarifies the selection of data sources used in such analyses to enhance and verify source validity; identifies additional means to es.
Appreciating aspirations in Australian higher education

Aspiration for higher education (HE) is no longer a matter solely for students and their families. With OECD nations seeking to position themselves more competitively in the global knowledge economy, the need for more knowledge workers has led to plans to expand their HE systems to near universal levels. In Australia, this has required the government and institutions to enlist students who traditionally have not seen university as contributing to their imagined and desired futures. However, this paper suggests that failing to appreciate the aspirations of different groups, understood as a collective cultural capacity, casts doubt over the ability of institutions to deliver increased numbers of knowledge workers. Moreover, inciting subscription to the current norms of HE is a weak form of social inclusion. Stronger forms of equity strategy are possible when HE is repositioned as a resource for different groups and communities to access in the pursuit of their aspirations.
No Exit, No Voice: Women's Economic Dependency and the Welfare State

Research on the welfare state has been particularly concerned with variations in inequality between societies. These studies tend to view the family as a unit of shared interests where incomes are pooled and distributed equally This study makes a theoretical and empirical case for why it is important to look at economic dependency within the family in comparative welfare state research. Hirschman's theoretical framework of exit and voice is applied to the power relations in the family Using comparative data from several Western societies, this study shows empirically that the relationship between overall inequality and women's economic dependency is rather weak. Some guidelines and directions for incorporating women's economic dependency into future comparative welfare state research are suggested.
Sterile corneal melting and necrotizing scleritis after cataract surgery in patients with rheumatoid arthritis and collagen vascular disease

The onset of post-operative corneal melting and necrotizing scleritis in patients with rheumatoid arthritis and collagen vascular disease who undergo cataract surgery can have devastating ocular and systemic consequences. Even though ocular surface factors such as sicca and surgical trauma are among the important variables that contribute to this entities, signs and symptoms of systemic disease need to be thoroughly investigated in order to prevent life-threatening complications associated with these ocular manifestations. The management of surgical induced corneal melting and necrotizing scleritis in these patients, include local therapy and in most instances, systemic immuno-modulation. Moreover, the development of corneal melting and necrotizing scleritis in an otherwise “healthy” patient after uncomplicated cataract surgery, can be the first manifestation of a serious occult systemic disease. Therefore, an aggressive approach regarding the diagnosis, workup and treatment should be initiated by the ophthalmologist in order to maximize a successful ophthalmic and medical outcome.
Cataract and cognitive impairment: a review of the literature

Acquired cataract and cognitive impairment are both common age-related problems, and ophthalmologists are increasingly likely to encounter patients who have both. Patients with dementia types who display early visuoperceptual impairment may present first to ophthalmology services. When these patients have coexisting cataract, it may be difficult to distinguish visual complaints due to cataract from those due to dementia. The interaction between visual impairment due to cataract and neurodegenerative disorders affecting the central visual pathways, is not fully understood. Visual impairment due to cataract may stress impaired attentional mechanisms and cataract extraction may improve cognitive performance in some patients with early cognitive impairment; however, the benefits of cataract surgery in established dementia are less clear. In this study, the literature on this subject was reviewed and the implications for practice were considered.
Fat distribution in non‐obese girls with and without precocious pubarche: central adiposity related to insulinaemia and androgenaemia from prepuberty to postmenarche

objective Precocious pubarche (PP) in girls is associated with hyperinsulinaemia and dyslipidaemia of prepubertal onset, and with ovarian hyperandrogenism and ovulatory dysfunction in adolescence, particularly if they also had prenatal growth restraint and postnatal growth acceleration. Hyperinsulinaemia may be the pathogenic key factor, possibly amplified by hyperandrogenaemia. While such PP girls do not have increased body mass index (BMI), we hypothesized that body fat mass and fat distribution may differ between PP girls and matched controls, and may relate to insulin and androgen levels.
Prevalence of mental disorder in female remand prisons

High rates of undetected mental disorder have been reported in male remand prisons. Little is known about the levels of mental disorder that are undetected among female remand prisoners. The aims of the study were to assess the prevalence of mental disorder in newly remanded female prisoners and the efficacy of the prison health screen at identifying mental disorder.Toachieve these aims consecutive female remand prisoners were screened for mental disorder at reception to prison. Diagnosis of mental disorder was compared with the findings from the standard prison health screen. There were 227 (59%) women who had at least one mental disorder (excluding substance dependence), of whom 42 (11%) were psychotic. The prison reception screening identified 81 women as having a mental disorder, and nine of them were psychotic. These results lead us to conclude that the prevalence of mental disorder, including psychoses, is very high in this population. The existing prison reception screening does not identify the majority of cases of mental disorder.
Teachers Teaching in the New Mediascape: Digital Immigrants or ‘Natural Born Cyborgs’?

Schooled in an earlier time, educators are laboring to find meaningful purchase in new media environments, unable to match the fluency and sophistication of their ‘digital native’ students. Yet is Marc Prensky's portrayal of teachers as ‘digital immigrants’ really an accurate rendering of the today's situation? Drawing on phenomenological and posthuman literature, the authors reconsider teachers' everyday involvements with technologies, and explore new ways of conceptualizing teachers and students in today's mediatic situation. They suggest that teachers and students alike are more aptly – and less divisively – visualized as digital migrants or nomadic cyborgs navigating and acclimatizing to a restless twenty-first-century educational scene.
On microarchitectural modeling for CNFET-based circuits

Carbon Nanotube Field-Effect-Transistors (CN-FETs) show great promise to be an alternative to traditional CMOS technology, due to their extremely high energy efficiency. Unfortunately, the lack of control over the Carbon NanoTube (CNT) growth process causes CNFET circuits to suffer from the CNT count variation, which degrades the CNFET circuit performance. Compared to the CMOS process variation, the CNT count variation exhibits asymmetric spatial correlation. In this work, we propose an analytic model that integrates the impact of the asymmetric spatial correlation into the key microarchitectural blocks. We use this model to evaluate the variations in circuit performance for different layout styles and microarchitectural parameters. We further explore the opportunity of leveraging the asymmetric spatial correlation for performance enhancement. Experimental results based on SPICE simulation and architectural simulations showed the accuracy and effectiveness of the proposed model.
Correctness of high-level transformation systems relative to nested conditions†

In this paper we introduce the notions of nested constraints and application conditions, short nested conditions. For a category associated with a graphical representation such as graphs, conditions are a graphical and intuitive, yet precise, formalism that is well suited to describing structural properties. We show that nested graph conditions are expressively equivalent to first-order graph formulas. A part of the proof includes transformations between two satisfiability notions of conditions, namely -satisfiability and -satisfiability. We consider a number of transformations on conditions that can be composed to construct constraint-guaranteeing and constraint-preserving application conditions, weakest preconditions and strongest postconditions. The restriction of rule applications by conditions can be used to correct transformation systems by pruning transitions leading to states violating given constraints. Weakest preconditions and strongest postconditions can be used to verify the correctness of transformation systems with respect to pre- and postconditions.
Comparison of Molecular Dynamics with Classical Density Functional and Poisson–Boltzmann Theories of the Electric Double Layer in Nanochannels

Comparisons are made among Molecular Dynamics (MD), Classical Density Functional Theory (c-DFT), and Poisson–Boltzmann (PB) modeling of the electric double layer (EDL) for the nonprimitive three component model (3CM) in which the two ion species and solvent molecules are all of finite size. Unlike previous comparisons between c-DFT and Monte Carlo (MC), the present 3CM incorporates Lennard-Jones interactions rather than hard-sphere and hard-wall repulsions. c-DFT and MD results are compared over normalized surface charges ranging from 0.2 to 1.75 and bulk ion concentrations from 10 mM to 1 M. Agreement between the two, assessed by electric surface potential and ion density profiles, is found to be quite good. Wall potentials predicted by PB begin to depart significantly from c-DFT and MD for charge densities exceeding 0.3. Successive layers are observed to charge in a sequential manner such that the solvent becomes fully excluded from each layer before the onset of the next layer. Ultimately, this layer filling phenomenon results in fluid structures, Debye lengths, and electric surface potentials vastly different from the classical PB predictions.