Miracle-dz/UniFAR-FTUs huggingface dataset:
Biomolecular Modification of Inorganic Crystal Growth

The fascinating shapes and hierarchical designs of biomineralized structures are an inspiration to materials scientists because of the potential they suggest for biomolecular control over materials synthesis. Conversely, the failure to prevent or limit tissue mineralization in the vascular, skeletal, and urinary systems is a common source of disease. Understanding the mechanisms by which organisms direct or limit crystallization has long been a central challenge to the biomineralization community. One prevailing view is that mineral‐associated macromolecules are responsible for either inhibiting crystallization or initiating and stabilizing non‐equilibrium crystal polymorphs and morphologies through interactions between anionic moieties and cations in solution or at mineralizing surfaces. In particular, biomolecules that present carboxyl groups to the growing crystal have been implicated as primary modulators of growth. Here we review the results from a combination of in situ atomic force microscopy (AFM).
Cellular atypia is negatively correlated with immunohistochemical reactivity of CD31 and vWF expression levels in canine hemangiosarcoma

Canine hemangiosarcoma (HSA) is one of the most common mesenchymal tumors in dogs. Its high metastatic and growth rates are usually associated with poor prognosis. Neoplastic cells of HSA can show various levels of cellular atypia in the same mass and may consist of various populations at different differentiated stages. Up to present, however, there is no report analyzing their differentiation states by comparing cellular atypia with differentiation-related protein expressions. To evaluate whether cellular atypia can be used as a differentiation marker in HSA, we analyzed correlation between cellular atypia and intensities of CD31 and von Willebrand Factor (vWF) staining in HSA cases. We also compared cellular atypia and expression levels of CD31 and vWF in each growth patterns. Our results show that cellular atypia was negatively correlated to CD31 and vWF expression levels but no significant correlation was found between growth patterns and cellular atypia or CD31 and vWF expression levels. Our study suggests that cellular atypia is useful for identifying differentiation levels in HSA cases. This study also provides useful information to determine differentiation levels of cell populations within HSA based only on morphological analysis, which will aid further HSA research such as identifying undifferentiation markers of endothelial cells or finding undifferentiated cell population in tissue sections.
Acinetobacter baumannii OmpA Is a Selective Antibiotic Permeant Porin.

OmpAAb is a conserved, abundantly expressed outer membrane porin in Acinetobacter baumannii whose presumed role in antibiotic permeation has not been clearly demonstrated. In this report, we use a titratable heterologous expression system to express OmpAAb in isolation and demonstrate selective passage of small molecule antibiotics through OmpAAb. ETX2514, a recently discovered broad-spectrum β-lactamase inhibitor, in combination with sulbactam, is currently in clinical testing for the treatment of drug-resistant A. baumannii infections. We demonstrate that ETX2514 permeates OmpAAb and potentiates the activity of sulbactam in an OmpAAb-dependent manner. In addition, we show that small modifications in the structure of ETX2514 differentially affect its passage through OmpAAb, revealing unique structure-porin-permeation relationships. Finally, we confirm the contribution of OmpAAb to bacterial fitness using a murine thigh model of A. baumannii infection. These results, combined with the high sequence homology of OmpA across Acinetobacter spp. , suggest that optimization of antibiotic entry through OmpAAb may prove to be a feasible medicinal chemistry design strategy for future antibacterial discovery efforts.
Health-Related Quality of Life in Pediatric Patients With Demyelinating Diseases: Relevance of Disability, Relapsing Presentation, and Fatigue

Objective Decreased health-related quality of life (HRQOL) in pediatric patients with multiple sclerosis is established, but little research has examined HRQOL in the broader pediatric demyelinating disease population, and predictors of reduced HRQOL are largely unexplored. We sought to (1) compare generic HRQOL and fatigue of pediatric patients with relapsing (i.e., multiple sclerosis and neuromyelitis optica) versus monophasic demyelinating diseases (i.e., acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, clinically isolated syndrome) and (2) examine the extent to which disability, relapsing disease, and fatigue predict HRQOL. Methods Child and/or parent-proxy reports of generic and fatigue-related HRQOL were collected for 64 pediatric patients with demyelinating diseases. HRQOL of the sample was compared with published healthy child norms. Independent samples t-tests compared HRQOL and fatigue for children with monophasic versus relapsing diseases. Regression analyses examined disability, disease presentation, and fatigue as potential predictors of HRQOL. Results Compared with healthy child norms, generic HRQOL was significantly lower for the demyelinating disorder group, for both child and parent reports across multiple domains. As hypothesized, the relapsing disease group reported lower overall HRQOL and more fatigue than the monophasic group. Disability and relapsing disease predicted lower HRQOL for both parents and children, whereas fatigue was only predictive per the child perspective. Conclusions Children with demyelinating diseases evidence significantly lower HRQOL than healthy peers, supporting need for intervention. Those with relapsing disease appear particularly at risk; targeting disability and fatigue may be fruitful areas for intervention.
Thoracic Surgery Information on the Internet: A Multilingual Quality Assessment

Background Previous data suggest that quality of Internet information regarding surgical conditions and their treatments is variable. However, no comprehensive analysis of website quality exists for thoracic surgery. Objective The aim of this study was to quantify website quality in a multilingual setting using an international standard for assessment. Methods Health On the Net (HON) principles may be applied to websites using an automated toolbar function. We used the English, French, Spanish, and German Google search engines to identify 12,000 websites using keywords related to thoracic conditions and procedures. The first 150 websites returned by each keyword in each language were examined. We compared website quality to assess for tertile (is the quality better in first, second, or third 50 websites returned) and language differences. A further analysis of the English site types was undertaken performing a comparative analysis of website provider types. Results Overall, there are a considerable number of websites devoted to thoracic surgery: “lung cancer” returned over 150 million websites. About 7.85% (940/11,967) of websites are HON-accredited with differences by search term (P<.001) and tertiles (P<.001) of the first 150 websites, but not between languages. Oncological keywords regarding conditions and procedures were found to return a higher percentage of HON-accreditation. The percentage of HON-accredited sites was similar across all four languages (P=.77). In general, the first tertile contained a higher percentage of HON-accredited sites for every keyword. Conclusions Clinicians should appreciate the lack of validation of the majority of thoracic websites, with discrepancies in quality and number of websites across conditions and procedures. These differences appear similar regardless of language. An opportunity exists for clinicians to participate in the development of informative, ethical, and reliable health websites on the Internet and direct patients to them.
0.45v and 18pA/MHz MCU SOC with advanced Adaptive Dynamic Voltage Control (ADVC)

An Ultra-low power MCU SOC is described with integrated DC to DC power management and Adaptive Dynamic Voltage Control (ADVC) mechanism. The SOC includes the complete Synopsys ARC EM5D core MCU, featuring a full set of DSP instructions and minimizing energy consumption at a wide range of frequencies: 312K-80MHz. On-die Silicon sensors are utilized to continuously change the operating voltage to optimize power/performance for a given frequency and environmental conditions and also to resolve yield and life time problems while operating at low voltages. The core operates between 0.45–1.1V volts with a direct battery connection for an input voltage of 1.0–3.8V. The peak energy efficiency is 18μA/MHz. A comparison to state-of-the-art commercial SOCs is presented, showing a 3–5x improved current/DMIPS (Dhrystone Million Instructions per sec) compared to the next best chip.
Effect of α-lipoic acid on symptoms and quality of life in patients with painful diabetic neuropathy

Objective To examine the effect of α-lipoic acid on neuropathic symptoms in patients with diabetic neuropathy (DN). Methods Patients with painful DN were treated with 600 mg/day α-lipoic acid, orally, for 40 days. Neuropathy Symptom Score (NSS), Subjective Peripheral Neuropathy Screen Questionnaire (SPNSQ) and douleur neuropathique (DN)4 questionnaire scores were assessed at baseline and day 40. Quality-of-life treatment effects were assessed by Brief Pain Inventory (BPI), Neuropathic Pain Symptom Inventory (NPSI) and Sheehan Disability Scale (SDS). Changes in body weight, arterial blood pressure, fasting serum glucose and lipids were also assessed. Results Out of 72 patients included, significant reductions in neuropathic symptoms were shown by reduced NSS, SPNSQ and DN4 scores at day 40 versus baseline. BPI, NPSI, and SDS in terms of work disability, social life disability, and family life disability scores were also significantly reduced. Moreover, 50% of patients rated their health condition as ‘very much better’ or ‘much better’ following α-lipoic acid administration. Fasting triglyceride levels were reduced, but no difference was found in body weight, blood pressure, fasting glucose, or other lipids at day 40 versus baseline. Conclusions A-lipoic acid administration was associated with reduced neuropathic symptoms and triglycerides, and improved quality of life.
Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability

The protein Themis1 enables thymocyte selection by promoting T cell receptor signaling. Tipping the signaling scales The strength of the signal produced by the T cell receptor (TCR) in response to self-antigen determines whether an immature thymocyte undergoes positive selection and matures into a T cell or negative selection and is eliminated to avoid autoreactivity. Both selection processes require the protein Themis1. By examining the effects of either loss or overexpression of Themis1 in thymocytes in mice, Zvezdova et al. determined that Themis1 enhances the activity of the guanine nucleotide exchange factor Vav1 and the stability of the TCR-associated adaptor protein Grb2, thus enabling TCR signaling. These data suggest that, although Themis1 also recruits a phosphatase to the TCR complex, the primary role for Themis1 is to enhance rather than inhibit TCR signaling to promote thymocyte development. The T cell signaling protein Themis1 is essential for the positive and negative selection of thymocytes in the thymus. Although the developmental defect that results from the loss of Themis1 suggests that it enhances T cell receptor (TCR) signaling, Themis1 also recruits Src homology 2 domain–containing phosphatase-1 (SHP-1) to the vicinity of TCR signaling complexes, suggesting that it has an inhibitory role in TCR signaling. We used TCR signaling reporter mice and quantitative proteomics to explore the role of Themis1 in developing T cells. We found that Themis1 acted mostly as a positive regulator of TCR signaling in vivo when receptors were activated by positively selecting ligands. Proteomic analysis of the Themis1 interactome identified SHP-1, the TCR-associated adaptor protein Grb2, and the guanine nucleotide exchange factor Vav1 as the principal interacting partners of Themis1 in isolated mouse thymocytes. Analysis of TCR signaling in Themis1-deficient and Themis1-overexpressing mouse thymocytes demonstrated that Themis1 promoted Vav1 activity both in vitro and in vivo. The reduced activity of Vav1 and the impaired T cell development in Themis1−/− mice were due in part to increased degradation of Grb2, which suggests that Themis1 is required to maintain the steady-state abundance of Grb2 in thymocytes. Together, these data suggest that Themis1 acts as a positive regulator of TCR signaling in developing T cells, and identify a mechanism by which Themis1 regulates thymic selection.
Information Transfer Capacity of Articulators in American Sign Language

The ability to convey information is a fundamental property of communicative signals. For sign languages, which are overtly produced with multiple, completely visible articulators, the question arises as to how the various channels co-ordinate and interact with each other. We analyze motion capture data of American Sign Language (ASL) narratives, and show that the capacity of information throughput, mathematically defined, is highest on the dominant hand (DH). We further demonstrate that information transfer capacity is also significant for the non-dominant hand (NDH), and the head channel too, as compared to control channels (ankles). We discuss both redundancy and independence in articulator motion in sign language, and argue that the NDH and the head articulators contribute to the overall information transfer capacity, indicating that they are neither completely redundant to, nor completely independent of, the DH.
Foldings and grazings of tori in current controlled interleaved boost converters

Interleaved boost converters (IBCs) are used when energy conversion is required at high current levels. Such converter systems may undergo various nonlinear phenomena which can affect their performance adversely. In this paper, we study an IBC and demonstrate the first instability through a Neimark–Sacker bifurcation, resulting in a torus. An analysis based on the calculation of the monodromy matrix reveals that the torus has a rather strange form as the complex Floquet multipliers that became unstable have a real value close to −1. We show that further variation in a parameter can result in novel nonlinear phenomena where the torus itself folds and grazes a switching manifold, resulting in a ‘wobbling’ of the closed loop that represents the torus in discrete time. Numerical and analytical results validate our work. Copyright © 2013 John Wiley & Sons, Ltd.
The Safety, Acceptability and Continuation Rate of Immediate Versus Delayed Insertion of Levonorgestrel Releasing Intrauterine System Following First Trimester Surgical Abortion: An Observational Study

Objective: To assess the safety, acceptability and six-month continuation rate of immediate versus delayed insertion of the levonorgestrel releasing intrauterine system (LNG-IUS) following surgical termination of first trimester pregnancy. Methods: This prospective observational study was conducted on 180 patients who underwent surgical abortion and opted for LNGIUS and divided into two groups; immediate group=86 and delayed group=94. Pain scores, adverse effects, acceptability and continuation rate were recorded. Results: More patients in the delayed insertion group exhibited higher perception of pain (p< 0.001) and requested additional analgesia upon LNG-IUS insertion (p< 0.05) with no significant difference between the two groups regarding other adverse effects (fainting, abnormal vaginal bleeding, expulsion and pelvic infection), request for removal and re-insertion of LNG-IUS (p>0.05). The continuation rate and patient acceptability in terms of overall satisfaction and recommendation to other women, were comparable between the two groups (p>0.05) while overall discomfort was higher in the delayed group at one, three and six months after insertion (p< 0.05) Conclusion: Although immediate insertion of LNG-IUS after first trimester surgical abortion has higher expulsion rate, yet it has lower pain intensity, request for additional analgesia and overall discomfort compared to delayed insertion of LNG-IUS with comparable continuation and acceptability rates at 6 months after insertion. Keywords: levonorgestrel releasing intrauterine system; abortion; post abortive contraception
Repulsive interaction between coplanar cracks in the double–cantilever geometry

Experiments on thin mica sheets are used to demonstrate that coplanar cracks in double-cantilever beam specimens do not universally attract each other, as conventionally portrayed, but, at long range, actually repel. An elasticity analysis explains the repulsion in terms of a compression zone, ≍0.35 times the beam half-thickness ahead of the crack tip, generated by bending moments from the cantilever arms on the remaining specimen section.
Remote Traumatic Brain Injury Is Associated with Motor Dysfunction in Older Military Veterans

Background Traumatic brain injury (TBI) has been identified as a risk factor for Parkinson's disease (PD). Motor dysfunction among TBI-exposed elders without PD has not been well characterized. We sought to determine whether remote TBI is a risk factor for motor dysfunction on exam and functionally relevant motor dysfunction in day-to-day life among independently living elders without PD. Methods This is a cross-sectional cohort study of independently living retired military veterans aged 50 or older with (n = 78) and without (n = 85) prior TBI-all without diagnosed PD. To characterize multidimensional aspects of motor function on exam, the Unified Parkinson's Disease Rating Scale (UPDRS) Motor Examination was performed by a board-certified neurologist and used to calculate a modified UPDRS (mUPDRS) global motor score and four domain scores (tremor, rigidity, bradykinesia, and posture/gait). Functionally relevant motor dysfunction was assessed via self-report of falls within the past year. Results In analyses adjusted for demographics and comorbidities that differed between groups, compared with veterans without TBI, those with moderate-to-severe TBI were more likely to have fallen in past year (33% vs. 14%, risk ratio 2.5 [95% confidence interval 1.1-5.4]), had higher (worse) mUPDRS global motor (p = .03) and posture/gait scores (p = .02), but not higher tremor (p = .70), rigidity (p = .21), or bradykinesia scores (p = .22). Mild TBI was not associated with worse motor function. Conclusions Remote moderate-to-severe TBI is a risk factor for motor dysfunction-defined as recent falls and impaired posture/gait-among older veterans. TBI-exposed older adults may be ideal candidates for aggressive fall-screening and prevention strategies.
Violence in E-rated video games.

CONTEXT Children's exposure to violence, alcohol, tobacco and other substances, and sexual messages in the media are a source of public health concern; however, content in video games commonly played by children has not been quantified. OBJECTIVES To quantify and characterize the depiction of violence, alcohol, tobacco and other substances, and sex in video games rated E (for "Everyone"), analogous to the G rating of films, which suggests suitability for all audiences. DESIGN We created a database of all existing E-rated video games available for rent or sale in the United States by April 1, 2001, to identify the distribution of games by genre and to characterize the distribution of content descriptors associated with these games. We played and assessed the content of a convenience sample of 55 E-rated video games released for major home video game consoles between 1985 and 2000. MAIN OUTCOME MEASURES Game genre; duration of violence; number of fatalities; types of weapons used; whether injuring characters or destroying objects is rewarded or is required to advance in the game; depiction of alcohol, tobacco and other substances; and sexual content. RESULTS Based on analysis of the 672 current E-rated video games played on home consoles, 77% were in sports, racing, or action genres and 57% did not receive any content descriptors. We found that 35 of the 55 games we played (64%) involved intentional violence for an average of 30.7% of game play (range, 1.5%-91.2%), and we noted significant differences in the amount of violence among game genres. Injuring characters was rewarded or required for advancement in 33 games (60%). The presence of any content descriptor for violence (n = 23 games) was significantly correlated with the presence of intentional violence in the game (at a 5% significance level based on a 2-sided Wilcoxon rank-sum test, t(53) = 2.59). Notably, 14 of 32 games (44%) that did not receive a content descriptor for violence contained acts of violence. Action and shooting games led to the largest numbers of deaths from violent acts, and we found a significant correlation between the proportion of violent game play and the number of deaths per minute of play. We noted potentially objectionable sexual content in 2 games and the presence of alcohol in 1 game. CONCLUSIONS Content analysis suggests a significant amount of violence in some E-rated video games. The content descriptors provide some information to parents and should be used along with the rating, but the game's genre also appears to play a role in the amount of violent play. Physicians and parents should understand that popular E-rated video games may be a source of exposure to violence and other unexpected content for children and that games may reward the players for violent actions.
New approaches in topical delivery through using various permeation barrier enhancers

Topical delivery of drug is an appealing ways of conservative way in administrating for systematic therapeutics. Human skin is refractive to most molecules, particularly hydrophilic ones, in spite of the existence of trans-barrier route. Overcoming the logical obstacle of skin transportation has become one of issue to design delivery systems of transdermal drug. The crucial of preserving this protective barrier after breaching nano- sized (5 nm - 10 µm) skin surface is for purposes of transdermal drug delivery. Alternatively, sufficient deformable and stable nano-sized carriers can help in achieving controlled and reliable drug delivery across skin barrier. Their ability to act as drug carriers on, in and ideally below skin barrier(s) must be preserved. A proper design of self-regulating, ultra-adaptable and stable hetero-aggregates can overt spontaneously and deliver drugs through primary skin barrier and minimizing the cutaneous drug clearance; this grants deep/targeted deposition and prolonged action of the carrier-transported drugs. Therapeutic products based on ultra- adaptable self-regulating, nano-sized (~100nm) carriers are under development. In meantime, there is tremendous potential to overcome the skin barrier in enhancing transport of drug molecules offered by chemicals. However, single chemicals are limited in their efficiency to interfere low concentration's skin barrier and will cause skin irritation at most for high concentration's skin barriers. However, chemical mixtures made up by many components resulted in supplying lofty potency to permeate the skin in contrast with single chemicals that not necessary cause irritation. This write-up is an overview on systems of chemical mixtures' employed synergistic offering a better process of enhancing permeation of skin.