Miracle-dz/UniFAR-FTUs huggingface dataset:
Reconciling the deformational dichotomy of the 2016 Mw 7.8 Kaikoura New Zealand earthquake

Following the 2016 Mw 7.8 Kaikoura earthquake, uncertainty over the nature of the coseismic rupture developed. Seismological evidence pointed to significant involvement of the subduction megathrust, while geodetic and field observations pointed to a shallow set of intracrustal faults as the main participants during the earthquake. The addition of tsunami observations and modeling as reported in Bai et al. (2017, https://doi.org/10.1002/2017GL073717) places additional constraints on the specific location of coseismic slip, which when combined with other observations indicates the simultaneous occurrence of shallow slip on the subduction interface and slip on overlying, upper crustal fault structures. This Kaikoura‐style earthquake, involving synchronous ruptures on multiple components of the plate boundary, is an important mode of plate boundary deformation affecting seismic hazard along subduction zones.
Cellular and Noncellular Approaches for Repairing the Damaged Blood–CNS–Barrier in Amyotrophic Lateral Sclerosis

Numerous reports have demonstrated the breakdown of the blood–CNS barrier (B-CNS-B) in amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Re-establishing barrier integrity in the CNS is critical to prevent further motor neuron degeneration from harmful components in systemic circulation. Potential therapeutic strategies for repairing the B-CNS-B may be achieved by the replacement of damaged endothelial cells (ECs) via stem cell administration or enhancement of endogenous EC survival through the delivery of bioactive particles secreted by stem cells. These cellular and noncellular approaches are thoroughly discussed in the present review. Specific attention is given to certain stem cell types for EC replacement. Also, various nanoparticles secreted by stem cells as well as other biomolecules are elucidated as promising agents for endogenous EC repair. Although the noted in vitro and in vivo studies show the feasibility of the proposed therapeutic approaches to the repair of the B-CNS-B in ALS, further investigation is needed prior to clinical transition.
Semiparametric Musculoskeletal Model for Reinforcement Learning-Based Trajectory Tracking

This article aims to solve the trajectory tracking task of the pneumatic musculoskeletal robot within a model-based reinforcement learning framework. Considering the limited sensors and short lifespan of self-made pneumatic artificial muscles, physics priors are encoded into Gaussian process regression to implement a semiparametric model for microdata system identification and the identified model is combined with cross-entropy method (CEM)-based model predictive control to plan for the optimal action online. To further compensate for the model imperfection and improve the control performance, a hybrid feedforward and feedback controller-like strategy is proposed to guide the search space of the original CEM solver. The effectiveness of our approach is verified on a real musculoskeletal manipulator with two degrees of freedom, and the results show that only 50 s of interacting with the environment is enough for the robot to learn writing alphabet letters from scratch.
miR-335-3p improves type II diabetes mellitus by IGF-1 regulating macrophage polarization

Abstract Previous studies have found that miR-335 is highly expressed in type II diabetes mellitus (T2DM) models and is related to insulin secretion, but there are few studies on the regulatory effects of miR-335-3p on insulin resistance and macrophage polarization in T2DM patients. This study aims to explore the effects of miR-335-3p on insulin resistance and macrophage polarization in T2DM patients. Blood glucose (insulin tolerance tests, glucose tolerance tests) and body weight of the T2DM model were measured; macrophages from adipose tissue were isolated and cultured, and the number of macrophages was detected by F4/80 immunofluorescence assay; the Real-time quantitative polymerase chain reaction (qPCR) assay and Western blot assay were used to detect the miR-335-3p expression levels, insulin-like growth factor 1 (IGF-1), M1-polarizing genes (inducible nitric oxide synthase [iNOS] and TNF-α) as well as M2-polarizing genes (IL-10 and ARG-1). The targeting link between miR-335-3p and IGF-1 was confirmed using bioinformatics and dual luciferase assay. The results showed that miR-335-3p expression level in adipose tissue of the T2DM model was significantly decreased, and the mice’s body weight and blood glucose levels dropped considerably, miR-335-3p inhibited the number of macrophages, inhibiting the iNOS and TNF-α relative mRNA expression levels, and up-regulated the IL-10 and ARG-1 relative mRNA expression levels, miR-335-3p negatively regulated target gene IGF-1, IGF-1 significantly increased the iNOS and TNF-α mRNA and protein expression levels, decreasing the IL-10 and ARG-1 mRNA and protein expression levels, indicating that miR-335-3p could affect the T2DM process by regulating macrophage polarization via IGF-1.
Assessing Long-Term Hydrological Impact of Climate Change Using an Ensemble Approach and Comparison with Global Gridded Model-A Case Study on Goodwater Creek Experimental Watershed

Potential impacts of climate change on the hydrological components of the Goodwater Creek Experimental Watershed were assessed using climate datasets from the Coupled Model Intercomparison Project Phase 5 and Soil and Water Assessment Tool (SWAT). Historical and future ensembles of downscaled precipitation and temperature, and modeled water yield, surface runoff, and evapotranspiration, were compared. Ensemble SWAT results indicate increased springtime precipitation, water yield, surface runoff and a shift in evapotranspiration peak one month earlier in the future. To evaluate the performance of model spatial resolution, gridded surface runoff estimated by Lund–Potsdam–Jena managed Land (LPJmL) and Jena Diversity-Dynamic Global Vegetation model (JeDi-DGVM) were compared to SWAT. Long-term comparison shows a 6–8% higher average annual runoff prediction for LPJmL, and a 5–30% lower prediction for JeDi-DGVM, compared to SWAT. Although annual runoff showed little change for LPJmL, monthly runoff projection under-predicted peak runoff and over-predicted low runoff for LPJmL compared to SWAT. The reasons for these differences include differences in spatial resolution of model inputs and mathematical representation of the physical processes. Results indicate benefits of impact assessments at local scales with heterogeneous sets of parameters to adequately represent extreme conditions that are muted in global gridded model studies by spatial averaging over large study domains.
Primary Liver Perivascular Epithelioid Cell Tumor (PEComa): Case Report and Literature Review

A primary liver perivascular epithelioid cell tumor (PEComa) is an extremely rare entity. In this article, we present a case report with a review of the literature on the patients diagnosed with primary liver PEComa and an elaboration of diagnostic and treatment modalities. A systematic literature search was conducted using the terms “perivascular epithelioid cell tumor”, “PEComa”, “liver”, and “hepatic”. All articles describing patients diagnosed with primary liver PEComa were included. We identified a total of 224 patients of primary liver PEComa from 75 articles and a case from the present study with a significant preponderance of females (ratio 4:1) and with a mean age of 45.3 ± 12.1 years. Most of the patients (114 out of 224, 50.9%) were asymptomatic. A total of 183 (81.3%) patients underwent surgical hepatic resection at the time of diagnosis, while 19 (8.4%) underwent surveillance. Recurrence and metastases were detected in seven (3.1%) and six (2.7%) patients, respectively. In conclusion, surgical resection remains the cornerstone of therapy; however, the presence of nonspecific imaging features makes it difficult to reach a definite diagnosis preoperatively. Therefore, a multidisciplinary approach should be the gold standard in selecting the treatment modality.
Combined islet and kidney xenotransplantation for diabetic nephropathy: an update in ongoing research for a clinically relevant application of porcine islet transplantation

Combined islet and kidney xenotransplantation for the treatment of diabetic nephropathy represents a compelling and increasingly relevant therapeutic possibility for an ever-growing number of patients who would benefit from both durable renal replacement and cure of the underlying cause of their renal insufficiency: diabetes. Here we briefly review immune barriers to islet transplantation, highlight preclinical progress in the field, and summarize our experience with combined islet and kidney xenotransplantation, including both challenges with islet-kidney composite grafts as well as our recent success with sequential kidney followed by islet xenotransplantation in a pig-to-baboon model.
Understanding the Cultural Trauma behind Identity Creating a Third Space in the Middle of Polarity

To anticipate the eternal polarization in the 2024 election, this study uses a critical perspective to trace the upstream of the problem of identity politics in Indonesia. By using digital ethnography methods, this study explores various narratives of cultural trauma that often circulate in the midst of election momentum as the root of the problem of identity politics. In this study, the psycho-social paradigm is used to read various narratives in Twitter conversations as a response to cultural trauma against social bodies that resist. By using a conceptual framework related to the process of forming a third space through digital media, this study offers a form of cultural trauma coping in a divided society.
Single Nucleotide Polymorphisms as Biomarker Predictors of Oral Mucositis Severity in Head and Neck Cancer Patients Submitted to Combined Radiation Therapy and Chemotherapy: A Systematic Review

Simple Summary Single Nucleotide Polymorphisms (SNPs) are the most common type of genetic variation found in an individual’s DNA sequences. SNPs can occur in both coding and non-coding regions of the genome and can affect gene expression, protein function, and disease susceptibility. In this systematic review, we evaluate the potential of SNPs as biomarkers in the assessment of oral mucositis (OM) severity in head and neck cancer (HNC) patients treated with concomitant chemoradiation (CRT). This systematic review demonstrates that SNPs in different biological pathways have the potential to be biomarkers and to function as predictors of patients who will develop severe mucositis. The most studied biological pathway was that involving DNA damage repair genes. However, considering the involvement of cytokines and inflammatory pathways in the pathophysiology of mucositis, we believe that this is a promising area in the study of the prediction of this condition. We conclude that SNPs can be used as possible biomarkers for the assessment of OM intensity in HNC patients, and further research is needed to explore the potential of SNPs in personalized medicine for HNC treatment. Abstract Single Nucleotide Polymorphisms (SNPs) are the most common type of genetic variation found in an individual’s DNA sequences. SNPs can occur in both coding and non-coding regions of the genome and can affect gene expression, protein function, and disease susceptibility. In this systematic review, we evaluate the potential of SNPs as biomarkers in the assessment of oral mucositis (OM) severity in head and neck cancer (HNC) patients treated with concomitant chemoradiation (CRT). The study selection process involved screening 66 articles from different platforms, and after removing duplicates and excluding articles that did not meet the eligibility criteria, 23 articles were included for full-text evaluation. Among them, genes from several pathways were analyzed. The DNA damage repair pathways had the highest number of genes studied. The most frequently analyzed gene was XRCC1. The proinflammatory cytokine pathways evaluated were TNF, with three articles, and NF-κB, with one article. Most included studies showed a potential association between certain SNPs and high-grade mucositis. We conclude that SNPs can be used as possible biomarkers for the assessment of OM intensity in HNC patients, and further research is needed to explore the potential of SNPs in personalized medicine for HNC treatment.
The Effect of Parental Control on Cyber-Victimization in Adolescence: The Mediating Role of Impulsivity and High-Risk Behaviors

The aim of this work is to analyze the relationship between parental control and cyber-victimization in adolescence, considering the possible mediating effect of impulsivity, and high-risk internet behavior. To that end we analyzed the responses of 3360 adolescents aged between 11 and 18 (M = 14.02; SD = 1.40), from Asturias (Spain), to four previously validated questionnaires in order to measure the level of parental control over the use of the internet (restriction and supervision), along with high-risk internet behaviors, impulsivity, and cyber-victimization in the adolescents. The results show that parental control tends to have a protective effect on the likelihood of the children being victims of cyber-aggression, with impulsivity, and high-risk internet behaviors as mediating variables. More specifically, parental restriction and supervision are positively related to each other; both forms of parental control are negatively related with the adolescent’s engaging in high-risk internet behaviors; supervision is negatively related with impulsivity; impulsivity is positively related with high-risk internet behaviors; and both impulsivity and high-risk internet behaviors are positively related to being a victim of cyber-aggression. The practical implications of these results are discussed.
Association between sleep duration and psychological resilience in a population-based survey: A cross-sectional study

BACKGROUND: The study aimed to find out the association between sleep duration and psychological resilience in a population-based survey. MATERIALS AND METHODS: A cross-sectional survey was conducted in August 2022, employing a cluster random sampling method to recruit community residents at Futian District in Shenzhen, China. A total of 2,445 participants aged 18 years and over were included in the study. The Brief Resilience Scale (BRS) was utilized to measure psychological resilience, and sleep duration was classified according to the American Heart Association’s sleep duration categories. Multivariable linear regression was used to analyze the relationship between psychological resilience and sleep duration after adjusting for gender, age, smoking status, physical exercise frequency, body mass index (BMI), and education level. RESULTS: The participants displayed moderate levels of psychological resilience, with a mean resilience score of 3.46 (standard deviation [SD] = 0.62) and a mean sleep duration of 7.04 h (SD = 1.10). After adjusting for covariates, longer sleep duration was associated with higher psychological resilience (β = 0.047, P < 0.05), indicating that participants with a long sleep duration had higher resilience scores than those with a short sleep duration. CONCLUSION: Longer sleep duration is positively associated with higher psychological resilience in community residents. These findings suggest that improving sleep duration may be a promising approach to enhancing psychological resilience, preventing psychological problems, and promoting overall physical and mental health development.
Community-based education: An effective policy for earthquake preparedness in Iran: Empirical study

BACKGROUND: As natural or man-made shocks, disasters are sudden events that require emergency and fundamental measures. The need to be prepared for disasters has become clearer than ever worldwide. This study aimed to investigate the effect of earthquake preparedness training using the face-to-face or cascade method in rural households living in Juybar County (Iran) in 2018. METHODS AND MATERIAL: Following an experimental design with a pretest and posttest, the study was performed on married women aged 10–49 living in Kurdkolay village of Juybar county (n = 372). Participants were randomly categorized into two groups of training (n = 95) and face-to-face cascade method (n = 95). Data were collected using the Disaster Preparedness Assessment Index, comprising demographic and education sections. Data were collected using the disaster preparedness assessment index and analyzed using SPSS version 24. RESULTS: The findings indicated improved preparedness in all five dimensions in both groups. There was a significant difference between the study groups immediately and one week after the intervention (P < 0.05); i.e. a higher impact for the face-to-face cascade method. Meanwhile, both groups presented a similar level of preparedness 90 days after receiving the intervention (P > 0.05). CONCLUSIONS: The face-to-face cascade method was more effective in the short term, while no difference was found in the long term. Crisis managers and policymakers should choose their preferred method based on available facilities, human resources, and context to increase preparedness against earthquakes. Mothers play a vital role in educating and nurturing their children. It is suggested to conduct educational programs at the community level using the most appropriate methods that are chosen based on the best evidence.
The Climate Response of Cedrela Fissilis Annual Ring Width in the Rio São Francisco Basin, Brazil

Abstract The São Francisco River basin is one of the most drought-prone regions of Brazil. Seasonally dry tropical forests (SDTF) are widely distributed in the basin and we developed a short chronology of Cedrela fissilis annual ring widths from SDTF fragments based on 89 cores from 44 trees dating from 1961 to 2015. The average correlation among all radii (RBAR) is 0.52. The tree-ring chronology is correlated with wet season precipitation totals, must strongly and consistently near the beginning of the wet season. The spatial pattern of correlation covers most of the southern portion of the Brazilian Drought Polygon and the sub-basins of the two largest tributaries of the São Francisco River, in some areas exceeding r = 0.60. The chronology is also correlated with total annual discharge of the Rio São Francisco River measured at Barra (r = 0.489; 1961–2015), which is very promising in a country that generates two thirds of its electricity from hydroelectric power plants, particularly if this short chronology can be extended with trees exceeding 150-years old known to still exist in the region.
Polymerase gene mutation pattern in patients of chronic Hepatitis B treatment in Prof. Dr. W.Z. Johannes Hospital, Kupang, Indonesia

Abstract. Djuma AW, Dewu S, Kambuno NT, Banunu A, Silaen OSM. 2024. Polymerase gene mutation pattern in patients of chronic Hepatitis B treatment in Prof. Dr. W.Z. Johannes Hospital, Kupang, Indonesia. Biodiversitas 25: 150-155. Hepatitis B virus (HBV) infection is a significant global health concern, impacting over two billion people worldwide. Among them, more than 240 million individuals develop chronic HBV infection, placing them at a high risk of developing severe liver conditions such as cirrhosis, liver failure, and Hepatocellular Carcinoma (HCC). In 2013, Nusa Tenggara Timur (NTT) emerged as one of the Indonesian provinces with a high incidence of hepatitis cases. Long-term therapy has proven effective in halting disease progression but may also lead to the emergence of resistant mutations. This study aims to analyze mutation patterns in the Polymerase (P) gene as indicators of viral resistance to nucleotide analogs (NUCs) in HBV patients at RSUD Prof. Dr. W.Z. Johannes Kupang, a previously unreported case. The research was conducted at the Hematology-Oncology Medical Laboratory Division, Faculty of Medicine, Universitas Indonesia, RS. Dr. Cipto Mangunkusumo, Department of Internal Medicine, Jakarta. A total of 28 individual samples with positive Hepatitis B surface Antigen (HBsAg) were subjected to PCR sequencing, resulting in 23 positive samples. Mutation profiles were analyzed by comparing them with the reference sequence M54923. Sequencing of the Polymerase (P) gene region was successfully carried out for 14 samples. Among these, 12 (85.71%) exhibited nucleotide substitutions, while the remaining two (9.14%) did not show any mutations. The most prevalent substitution patterns in the P gene included rtQ228H, rtS127R, rtM135L, rtV243I, rtL257A, rtS127A, rtK323N, rtL326R, rtV214I, rtT312S, rtV281E, rtF290Y, rtM299I, rtQ306H, and rtK308N. No mutations associated with antiviral resistance were detected. The use of NUCs in chronic hepatitis B treatment is considered safe for patients at Prof. Dr. W.Z. Johannes Kupang Hospital.
The Effect of Job Satisfaction and Compensation on Employee Performance with Work Motivation as Mediation in 4-Star Hotels Batam City

This research investigates the impact of job satisfaction and compensation on employee performance in a 4-star hotel in Batam City, utilizing work motivation as a mediator. Job satisfaction and compensation are recognized as crucial factors influencing both work motivation and employee performance. The administration of a questionnaire to 380 hotel employees in Batam City yielded positive and significant correlations between job satisfaction, compensation, work motivation, and employee performance, as revealed by PLS analysis. Work motivation emerges as a significant mediator in the relationships between job satisfaction and employee performance, as well as between compensation and employee performance. Keywords: Employee Performance, Work Motivation, Job Satisfaction, Compensation
Geochemical Characterization And Petrogenesis Of The Scapolite–Bearing Gneisses In The Dahomeyide Suture Zone, South–Eastern Ghana

iii DEDICATION . v ACKNOWLEDGEMENT . vi TABLE OF CONTENT . vii LIST OF FIGURES . xi LIST OF ABBREVIATIONS . xviii CHAPTER ONE . 1 University of Ghana http://ugspace.ug. edu.gh
Multi‐decadal glacier surface lowering in the Antarctic Peninsula

From approximately 400 glaciers of the western Antarctic Peninsula, no in situ records of mass balance exist and their recent contribution to sea level is consequently poorly constrained. We seek to address this shortcoming by using surface elevations from USGS and BAS airborne (1948–2005) and ASTER spaceborne (2001–2010) stereo imagery, combined by using a rigorous semi‐automated registration approach, to determine multi‐decadal glacier surface elevation changes in the western Antarctic Peninsula for 12 glaciers. All observed glaciers show near‐frontal surface lowering and an annual mean lowering rate of 0.28 ± 0.03 m/yr at the lower portion of the glaciers during the ∼4 decades following the mid‐1960s, with higher rates for the glaciers in the north‐west parts of the Antarctic Peninsula. Increased lowering of up to 0.6 m/yr can be observed since the 1990s, in close correspondence to increased atmospheric positive degree days. In all cases, surface lowering reduces to zero within 5 km of the glacier front at around 400 m altitude. This lowering may have been at least partially compensated for by increased high‐altitude accumulation.