Miracle-dz/UniFAR-FTUs huggingface dataset:
Tissue Plasminogen Activator for Acute Ischemic Stroke in Clinical Practice

Background and Purpose—Concerns persist regarding the safety of tissue plasminogen activator (tPA) therapy for acute ischemic stroke. Numerous case series of clinical experience with tPA have been published that provide additional data on the safety of thrombolytic therapy. Methods—This is a meta-analysis of 15 published, open-label studies that broadly followed approved indications and guidelines for tPA use in nonselective patient populations. Results—In 2639 treated patients, the symptomatic intracerebral hemorrhage rate was 5.2% (95% confidence interval, 4.3 to 6.0), slightly lower than the 6.4% rate in the treated group of the randomized, placebo-controlled National Institute of Neurological Disorders and Stroke (NINDS) trial. The mean total death rate (13.4%) and proportion of subjects achieving a very favorable outcome (37.1%) were comparable to the NINDS trial results. Protocol deviations were reported in 19.8%. Comparing across studies showed that the mortality rate was correlated with the percentage of protocol violations (r 0.67, P 0.018). Conclusions—Postapproval data support the safety of intravenous thrombolytic therapy with tPA for acute ischemic stroke, especially when established treatment guidelines are followed. (Stroke. 2003;34:2847-2850.)
Alteration of cardiac autonomic function in patients with newly diagnosed epilepsy

The aim of the study was to determine if heart rate variability (HRV) showed any changes in patients with newly diagnosed epilepsy in comparison with controls. Sixty‐five patients with epilepsy (38 males and 27 females), aged 30–50 years, who had never previously received treatment with antiepileptic drugs were eligible for inclusion in this study. Resting electrocardiogram (ECG) at spontaneous respiration was recorded for 5 min in supine position. Time‐domain analysis, frequency‐domain analysis, and Poincare plot of HRV were recorded from ECG. In time‐domain measures, the square root of the mean of the sum of the squares of differences between adjacent RR intervals (RMSSD) and percentage of consecutive RR intervals that differ by more than 50 msec (pNN50) were significantly less in patients with epilepsy. In frequency‐domain measures, high frequency [(HF) msec2], HF (nu), and low frequency [LF (msec2)] were significantly less in patients with epilepsy while LF (nu) and LF/HF were significantly high in patients with epilepsy. In Poincare plot, standard deviation perpendicular to line of Poincare plot (SD1) and standard deviation along the line of entity in Poincare plot (SD2) were significantly less in patients with epilepsy. Our results suggest that epileptic patients have an impact on the cardiac autonomic function as measured by HRV.
Demographic Consequences Of Managing For Florida Scrub-jays (aphelocoma Coerulescens) On An Isolated Preserve.

Many species naturally occupy discrete habitat patches within a mosaic of habitats that vary in quality. The Florida scrub-jay (Aphelocoma coerulescens) is endemic to Florida scrub, a habitat that is naturally patchy and greatly reduced in area over recent decades owing to development and urbanization. Because of this habitat loss, future management of Florida scrubjays will focus on smaller, fragmented tracts of land. My study examines such a tract, Lyonia Preserve, southwest Volusia County, FL. This preserve was unoccupied by scrub-jays prior to habitat restoration. The preserve is now frequently managed exclusively for scrub-jays as a habitat island surrounded by development. Management of the preserve includes roller chopping, root raking, timbering, and “oak stripping” where islands of oak patches are left intact while the rest of the area is roller chopped. I investigate what, if any, demographic consequences may be associated with the habitat management and the spatial setting of the preserve. I used population data collected in this area since 1992 to examine population growth and responses to habitat restoration within the preserve and habitat destruction outside the preserve. I mapped territories and measured survival and recruitment of scrub-jays, and dispersal into and out of the study area, for two and a half years. Since restoration, the population has shown logistic growth, with the area supporting higher than average densities of scrub-jay family groups. Observed density of the population and territory size varied between study years. Breeder survival values were positively related to territory size and significantly lower during periods of highest observed density. However, recruitment (yearling production) showed no relationship to territory size. Dispersal to isolated habitat patches was observed; likewise, several failed dispersal events were noted. No immigration into the study area was observed; however these data may be underrepresented
Enabling Data Analytics from Knowledge Graphs

Scientific data is being acquired in high volumes in support of studies in many knowledge areas. Regular data analytics processes make use of datasets that often lack enough knowledge to facilitate the work of data scientists. By relying on knowledge graphs (KGs), those difficulties can be mitigated. This research focuses on enabling data analytics over scientific data in light of knowledge available in KGs, providing access, based on queries, to scientific data points in KGs to data users while making use of available knowledge to facilitate their data analytics activities.
Structure–activity study of macropin, a novel antimicrobial peptide from the venom of solitary bee Macropis fulvipes (Hymenoptera: Melittidae)

A novel antimicrobial peptide, designated macropin (MAC‐1) with sequence Gly‐Phe‐Gly‐Met‐Ala‐Leu‐Lys‐Leu‐Leu‐Lys‐Lys‐Val‐Leu‐NH2, was isolated from the venom of the solitary bee Macropis fulvipes. MAC‐1 exhibited antimicrobial activity against both Gram‐positive and Gram‐negative bacteria, antifungal activity, and moderate hemolytic activity against human red blood cells. A series of macropin analogs were prepared to further evaluate the effect of structural alterations on antimicrobial and hemolytic activities and stability in human serum. The antimicrobial activities of several analogs against pathogenic Pseudomonas aeruginosa were significantly increased while their toxicity against human red blood cells was decreased. The activity enhancement is related to the introduction of either l‐ or d‐lysine in selected positions. Furthermore, all‐d analog and analogs with d‐amino acid residues introduced at the N‐terminal part of the peptide chain exhibited better serum stability than did natural macropin. Data obtained by CD spectroscopy suggest a propensity of the peptide to adopt an amphipathic α‐helical secondary structure in the presence of trifluoroethanol or membrane‐mimicking sodium dodecyl sulfate. In addition, the study elucidates the structure–activity relationship for the effect of d‐amino acid substitutions in MAC‐1 using NMR spectroscopy. Copyright © 2014 European Peptide Society and John Wiley & Sons, Ltd.
THE AUTOMATIC IDENTIFICATION SYSTEM (AIS) AS A DATA SOURCE FOR STUDYING MARITIME TRAFFIC

The Automatic Identification System (AIS) is an automatic tracking system used on as a tool to increase navigation safety and efficiency as well as vessel traffic management. It enhances maritime safety and security. AIS' contributions are undeniable in spite of some deficiencies and technical restrictions. This article presents the impacts and uses of AIS technology that can provide useful information to study maritime traffic, especially for the scientific community and port authorities. This desktop study is carried out in the framework of the implementation of a platform to reconstruct shipping routes using AIS data.
Automatic Morphological Tagging of Contemporary Uighur Corpus

In this paper, we propose methods of Uighur word lemmatization by using of morphemic analysis and word's structural analysis, integrating morphological processing and part-of speech (POS) tagging, so as to find linguistic information and automatic POS of Uighur Corpus as the final purpose. For the regular words, the accuracy of word lemmatization reach 85% and POS reach 80%
Design of optical aggregation network with carrier edge functions virtualization

NFV (network functions virtualization) enables carrier edge functions to be relocated from dedicated hardware to distributed pools of commodity servers, which reduces network cost and improves robustness to unpredictable demand changes. The key to this lies in how to place each VNF (virtual network function) on an adequate server among pools in conjunction with design of paths connecting servers with OLTs (optical line terminals). There have been extensive studies regarding VNF placement problems, but few have investigated the optimal placement of VNFs in consideration of carrier edge function virtualization. We thus study a design problem of carrier edge VNF placement in an optical aggregation network. We formulate a design problem as MILP (mixed-integer linear programming) and demonstrate the effectiveness of the proposed method through intensive mathematical experiments. The experiments showed that the proposed method reduced the maximum server load and network cost by up to by 29% and 21%, respectively.
The Value of Information and Intensity of Preference

Previous research has documented the lack of clear relationships between the value of information and characteristics of the decision problem. This paper shows that the intensity of the decision maker's preference toward the prior choice alternatives can be regarded as the primary determinant of information value. The value of an information source, measured in utility units, is maximal when the decision maker is indifferent vis-a-vis the prior alternatives, and it is lower as the preference for one alternative over the others gets stronger. This holds under quite general conditions, which are made explicit, and for any decision maker's utility function, wealth, and background risks. The maximum buying price of information follows the same pattern for linear utility and, with a restriction, exponential utility, and this may hold approximately for other types of utility functions. The result provides a general, concise, and intuitive explanation for seemingly ill-behaved variations in the value of information. It indicates that nonmonotonic, quasi-concave relationships should generally be expected between value of information and parameters of the decision problem.
Survey estimators that respect natural orderings

Many variables in surveys follow natural orderings that should be respected in estimates of domain means. For instance, the National Compensation Survey estimates mean wages for many job categories, and these mean wages are expected to be non-decreasing according to job level. In this type of situation, isotonic regression can be applied to give constrained estimators satisfying the monotonicity. We combine domain estimation and the pooled adjacent violators algorithm to 10 construct new design-weighted constrained estimators. Under mild conditions on the sampling design and the population, the estimators are shown to be design consistent and asymptotically normal. Confidence intervals for domain means using linearization-based and replication-based variance estimation show marked improvements compared to survey estimators that do not incorporate the constraints. 15
Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma

Fractionation of MOPC 41 DL-1 tumors revealed that the mRNA for the light chain of immunoglobulin is localized exclusively in membrane- bound ribosomes. It was shown that the translation product of isolated light chain mRNA in a heterologous protein-synthesizing system in vitro is larger than the authentic secreted light chain; this confirms similar results from several laboratories. The synthesis in vitro of a precursor protein of the light chain is not an artifact of translation in a heterologous system, because it was shown that detached polysomes, isolated from detergent-treated rough microsomes, not only contain nascent light chains which have already been proteolytically processed in vivo but also contain unprocessed nascent light chains. In vitro completion of these nascent light chains thus resulted in the synthesis of some chains having the same mol wt as the authentic secreted light chains, because of completion of in vivo proteolytically processed chains and of other chains which, due to the completion of unprocessed chains, have the same mol wt as the precursor of the light chain. In contrast, completion of the nascent light chains contained in rough microsomes resulted in the synthesis of only processed light chains. Taken together, these results indicate that the processing activity is present in isolated rough microsomes, that it is localized in the membrane moiety of rough microsomes, and, therefore, that it was most likely solubilized during detergent treatment used for the isolation of detached polysomes. Furthermore, these results established that processing in vivo takes place before completion of the nascent chain. The data also indicate that in vitro processing of nascent chains by rough microsomes is dependent on ribosome binding to the membrane. If the latter process is interfered with by aurintricarboxylic acid, rough microsomes also synthesize some unprocessed chains. The data presented in this paper have been interpreted in the light of a recently proposed hypothesis. This hypothesis, referred to as the signal hypothesis, is described in greater detail in the Discussion section.
Cloning and Characterization of KCC3 and KCC4, New Members of the Cation-Chloride Cotransporter Gene Family*

The K+-Cl−cotransporters (KCCs) belong to the gene family of electroneutral cation-chloride cotransporters, which also includes two bumetanide-sensitive Na+-K+-2Cl−cotransporters and a thiazide-sensitive Na+-Cl− cotransporter. We have cloned cDNAs encoding mouse KCC3, human KCC3, and human KCC4, three new members of this gene family. The KCC3 and KCC4 cDNAs predict proteins of 1083 and 1150 amino acids, respectively. The KCC3 and KCC4 proteins are 65–71% identical to the previously characterized transporters KCC1 and KCC2, with which they share a predicted membrane topology. The four KCC proteins differ at amino acid residues within key transmembrane domains and in the distribution of putative phosphorylation sites within the amino- and carboxyl-terminal cytoplasmic domains. The expression of mouse KCC3 in Xenopus laevis oocytes reveals the expected functional characteristics of a K+Cl− cotransporter: Cl−-dependent uptake of86Rb+ which is strongly activated by cell swelling and weakly sensitive to furosemide. A direct functional comparison of mouse KCC3 to rabbit KCC1 indicates that KCC3 has a much greater volume sensitivity. The human KCC3 and KCC4 genes are located on chromosomes 5p15 and 15q14, respectively. Although widely expressed, KCC3 transcripts are the most abundant in heart and kidney, and KCC4 is expressed in muscle, brain, lung, heart, and kidney. The unexpected molecular heterogeneity of K+-Cl− cotransport has implications for the physiology and pathophysiology of a number of tissues.
Community-based service location

lthough both computing and communications capabilities are improving exponentially, there has been a more rapid increase in available bandwidth than in computing power over recent years [6]. Naturally enough, while the network-related improvements create new possibilities for applications, the improvements and especially their differential, render obsolete traditional ways of thinking about telecommunications and computing. There is an ongoing debate occurring among two main factions within the telecommunications industry [1, 4]. On one side are traditional telephone companies, who advocate intelligent networks with increased intelligence embedded within the network and controlled by the telecommunications providers. The intelligence would be reflected in features such as for caller identification or call forwarding. On the other side are the proponents of (what may be called) stupid networks, who take their inspiration from the Internet. In this view, as bandwidth becomes plentiful, intelligence will propagate to the edges of the network and the network itself will provide no more than bit transport. The overwhelming advantage of stupid networks is that, like the Internet, they naturally support heterogeneity and extensibility. End users can choose whichever applications they like and invoke whichever services they prefer without requiring consistent changes throughout a large network. Consider telephone directories. White pages and yellow pages are essential for making a telecommunications system practical, but are classical centralized functionalities. Internet portals are a close analogue of telephone directories, and provide a one-size-fits-all solution to users’ information needs. However, just as advances in computing are driving manufacturing from mass production to mass customization, advances in communication are driving information access from large portals toward personal contacts. Large portals won’t be eliminated, but will increasingly be supplemented and superseded by personalized sources of information as people increasingly want to receive information and advice from those whom they know and trust. Accordingly, in this article we consider the problem of service location. We study an approach that places the intelligence on the endpoints, enabling the users to locate desirable services based on trustworthy, personalized recommendations of their peers. The task is not only to locate a particular service, but also to locate a service that is rated highly by one’s friends and associ-
Colonic metaproteomic signatures of active bacteria and the host in obesity

Obesity is associated with the intestinal microbiota in humans but the underlying mechanisms are yet to be fully understood. Our previous phylogenetic study showed that the faecal microbiota profiles of nonobese versus obese and morbidly obese individuals differed. Here, we have extended this analysis with a characterization of the faecal metaproteome, in order to detect differences at a functional level. Proteins were extracted from crude faecal samples of 29 subjects, separated by 1D gel electrophoresis and characterized using RP LC–MS/MS. The peptide data were analyzed in database searches with two complementary algorithms, OMSSA and X! Tandem, to increase the number of identifications. Evolutionary genealogy of genes: nonsupervised orthologous groups (EggNOG) database searches resulted in the functional annotation of over 90% of the identified microbial and human proteins. Based on both bacterial and human proteins, a clear clustering of obese and nonobese samples was obtained that exceeded the phylogenetic separation in dimension. Moreover, integration of the metaproteomics and phylogenetic datasets revealed notably that the phylum Bacteroidetes was metabolically more active in the obese than nonobese subjects. Finally, significant correlations between clinical measurements and bacterial gene functions were identified. This study emphasizes the importance of integrating data of the host and microbiota to understand their interactions.
Forwarders vs. centralized server: an evaluation of two approaches for locating mobile agents

The Internet has allowed the creation of huge amounts of data located on many sites. Performing complex operations on some data requires that the data be transferred first to the machine on which the operations are to be executed, which may require a non-negligible amount of bandwidth and may seriously limit performance if it is the bottleneck. However, instead of moving the data to the code, it is possible to move the code to the data, and perform all the operations locally. This simple idea has led to a new paradigm called code-mobility: a mobile object --- sometimes called an agent --- is given a list of destinations and a series of operations to perform on each one of them. The agent will visit all of the destinations, perform the requested operations and possibly pass the result on to another object. Any mobility mechanism must first provide a way to migrate code from one host to another. It must also ensure that any communication following a migration will not be impaired by it, namely that two objects should still be able to communicate even if one of them has migrated. Such a mechanism is referred to as a location mechanism since it often relies on the knowledge of the location of the objects to ensure communications. Two location mechanisms are widely used: the first one uses a centralized server whereas the second one relies on special objects called forwarders.This paper evaluates and compares the performance of an existing implementation of these approaches in terms of cost of communication in presence of migration. Based on a Markov chain analysis, we will construct and solve two mathematical models, one for each mechanism and will use them to evaluate the cost of location. For the purpose of validation, we have developed for each mechanism a benchmark that uses ProActive [2], a Java library that provides all the necessary primitives for code mobility. Experiments conducted on a LAN and on a MAN have validated both models and have shown that the location server always performs better than the forwarders. Using our analytical models we will nevertheless identify situations where the opposite conclusion holds. However, under most operational conditions location servers will perform better than forwarders.
Sensor fault detection and isolation for a class of nonlinear systems using sliding mode observer

The present paper proposes a new scheme based on sliding mode observers (SMOs) for sensor fault detection and isolation for a class of uncertain nonlinear systems. By using the integral observer approach, sensor faults are treated as actuator faults. A state and output transformation is introduced to transform the original system into two subsystems. One subsystem is subject to system uncertainties but free from sensor faults. A sliding mode observer is designed for this system so that the effect of uncertainties can be eliminated. The second subsystem is only subject to sensor faults but system uncertainties. A Luenberger observer is designed for this system for the purpose of fault detection. The sensor faults can be further isolated by applying a bank of SMOs to the second subsystem. The sufficient condition of stability of the proposed SMOs has been derived and expressed as Linear Matrix Inequalities (LMIs). The design parameters of the proposed SMOs are determined by using LMI techniques. The effectiveness of the proposed SMOs in detecting and isolating sensor faults has been illustrated considering a numeral example. The result has been found to be satisfactory even for incipient sensor faults which are hard to be detected due to the nature of small in size and growing slowly during the initial phase.