Miracle-dz/UniFAR-FTUs huggingface dataset:
Herpes Simplex Virus 1 Tegument Protein US11 Downmodulates the RLR Signaling Pathway via Direct Interaction with RIG-I and MDA-5

ABSTRACT The interferon (IFN)-mediated antiviral response is a major defense of the host immune system. In order to complete their life cycle, viruses must modulate host IFN-mediated immune responses. Herpes simplex virus 1 (HSV-1) is a large DNA virus containing more than 80 genes, many of which encode proteins that are involved in virus-host interactions and show immune modulatory capabilities. In this study, we demonstrate that the US11 protein, an RNA binding tegument protein of HSV-1, is a novel antagonist of the beta IFN (IFN-β) pathway. US11 significantly inhibited Sendai virus (SeV)-induced IFN-β production, and its double-stranded RNA (dsRNA) binding domain was indispensable for this inhibition activity. Additionally, wild-type HSV-1 coinfection showed stronger inhibition than US11 mutant HSV-1 in SeV-induced IFN-β production. Coimmunoprecipitation analysis demonstrated that the US11 protein in HSV-1-infected cells interacts with endogenous RIG-I and MDA-5 through its C-terminal RNA-binding domain, which was RNA independent. Expression of US11 in both transfected and HSV-1-infected cells interferes with the interaction between MAVS and RIG-I or MDA-5. Finally, US11 dampens SeV-mediated IRF3 activation. Taken together, the combined data indicate that HSV-1 US11 binds to RIG-I and MDA-5 and inhibits their downstream signaling pathway, preventing the production of IFN-β, which may contribute to the pathogenesis of HSV-1 infection.
Abnormality as a positive characteristic: The development and validation of a scale measuring need for uniqueness.

Need for uniqueness is introduced as a positive striving for abnormality relative to other people. Recent research regarding situational determinants of uniqueness motivation is described, and a dispositional individual-differences measure of need for uniqueness is presented. The development of the Uniqueness Scale aims at insuring construct validity as a guide for the item selection. The internal reliabilities, item-remainder coefficients, test-retest reliabilities, cross-validation information, factor analysis, and discriminant validation data are presented, and all meet the normal psychometric criteria expected of an individual-differences measure. Additionally, eight separate validational studies are presented. Abnormal psychology, as evidenced by the contents of books and journal articles in the area, has typically focused on the negative perspective of deviance. As Sarason (1972) notes in the introductory paragraph of his abnormal psychology text, "The term 'abnormal psychology' has traditionally referred to the study of human failures and inadequacies" (p. 3). While the manifestation of abnormal or deviant behavior is most commonly conceptualized as maladaptive, this need not be the case. One of the problems, however, with the terms abnormality and deviance is that they carry negative connotations (cf. Freedman & Doob, 1968). Therefore, the present article espouses the term uniqueness to circumvent the connotative qualities of abnormality and deviance. By uniqueness, we mean to convey a positive striving for differentness relative to other people. The theoretical underpinning of the uniqueness motivation construct and the de
Delay analysis of Ethernet passive optical networks with gated service

We analyze the mean packet delay in an Ethernet passive optical network (EPON) with gated service. For an EPON with a single optical network unit (ONU), we derive (i) a closed form delay expression for reporting at the end of an upstream transmission, and (ii) a Markov chain-based approach requiring the numerical solution of a system of equations for reporting at the beginning of an upstream transmission. Reporting at the beginning, which has not been previously examined in detail, achieves significantly smaller delays than reporting at the end of an upstream transmission for a small number of ONUs. Both of these analyses are fundamentally different from existing polling system analyses in that they consider the dependent switchover times of the EPON. We extend the analysis for reporting at the beginning of an upstream transmission to approximate the mean packet delay in an EPON with multiple ONUs and verify the accuracy of the analysis with simulations. Overall, our numerical results indicate that for utilizations up to ~75%, the mean packet delay is close to its minimum of four times the one-way propagation delay.
Fully automatable two‐dimensional reversed‐phase capillary liquid chromatography with online tandem mass spectrometry for shotgun proteomics

Herein, we describe the development of a fully automatable technology that features online coupling of high‐pH RP separation with conventional low‐pH RP separation in a two‐dimensional capillary liquid chromatography (2‐D LC) system for shotgun proteomics analyses. The complete analysis comprises 13 separation cycles, each involving transfer of the eluate from the first‐dimension, high‐pH RP separation onto the second RP dimension for further separation. The solvent strength increases across the 13 fractions (cycles) to elute all peptides for further resolution on the second‐dimension, low‐pH RP separation, each under identical gradient‐elution conditions. The total run time per analysis is 52 h. In triplicate analyses of a lysate of mouse embryonic fibroblasts, we used this technology to identify 2431 non‐redundant proteins, of which 50% were observed in all three replicates. A comparison of RP‐RP 2‐D LC and strong cation exchange‐RP 2‐D LC analyses reveals that the two technologies identify primarily different peptides, thereby underscoring the differences in their separation chemistries.
Wirksamkeit und Verträglichkeit von Frovatriptan in der Praxis

Zusammenfassung Im Rahmen zweier Anwendungsbeobachtungen in den Jahren 2003 und 2004 zur Beurteilung der Wirksamkeit und Verträglichkeit von 2,5 mg Frovatriptan wurden von 4 241 niedergelassenen Ärzten Daten zur Vortherapie sowie die Therapieverläufe einer einzelnen Migräneattacke unter Frovatriptan bei 16 737 Patienten dokumentiert. Beide Studien schlossen Patienten mit Migräne mit und ohne Aura entsprechend der IHS-Kriterien ein. Frauen waren mit 81% überrepräsentiert. Das Alter der Patienten betrug im Median 42,6 Jahre. Die Dauer der Migräne wurde mit einem Mittelwert von 10,4 Jahren angegeben. Die meisten Patienten (53,7%) gaben an, bis zu 2 Attacken pro Monat zu haben. Die übliche Kopfschmerzstärke wurde von 48,5% der Patienten als schwer beschrieben und von 47,5% als mittelschwer. Die übliche Dauer der gesamten Migräneattacke betrug bei 54,2% der Patienten mehr als 24 Stunden. Die Fravotriptanwirkung setzte innerhalb von 40 Minuten ein (Median), wiederkehrende Kopfschmerzen waren bei 18,8% der Patienten zu beobachten. Die Dauer der gesamten mit Frovatriptan behandelten Attacken betrug bei 84% der Patienten nur noch bis zu 24 Stunden. Im Vergleich zur bisherigen Therapie wurde die Frovatriptan-Behandlung von 87,5% der Patienten als besser wirksam gegen Kopfschmerzen und von 71,2% als besser wirksam gegen Übelkeit/Erbrechen und auch als verträglicher bewertet. Gleiches gilt für die Bewertungen durch die Ärzte hinsichtlich der besseren Wirksamkeit (87,9%) und der besseren Verträglichkeit (73,5%). In beiden Studien wurde der Wunsch zur Fortbehandlung mit Frovatriptan in 92,3% geäußert. Die Rate an Patienten mit unerwünschten Arzneimittelwirkungen lag bei 0,36%. Auf Grund des raschen Wirkeintritts und der langen Wirkungsdauer ist die Frovatriptan-Therapie effektiv und trägt im Zusammenhang mit der guten Verträglichkeit und der geringen Recurrence-Rate zur Compliance bei.
Endovascular occlusion of the carotid or vertebral artery with temporary proximal flow arrest and microcoils: clinical results.

PURPOSE To determine the clinical effectiveness of parent artery occlusion of the carotid or vertebral artery by means of temporary proximal flow arrest and microcoils. METHODS Nineteen parent artery occlusions (15 carotid, four vertebral) were performed in 19 patients who successfully passed a balloon test occlusion. In these patients, endovascular occlusion of the carotid or vertebral artery was accomplished with the use of temporary proximal flow arrest and microcoils. RESULTS All 19 parent arteries were occluded. Eighteen patients (95%) had good outcomes and one (5%) had a poor outcome. Fourteen patients (74%) had no complications and five (26%) had complications, of whom only one was left with a permanent neurologic deficit. Three (60%) of the complications were the result of delayed ischemic events after parent artery occlusion and were not predicted by balloon test occlusion. CONCLUSION Endovascular occlusion with temporary proximal flow arrest and microcoils can be done effectively and successfully. The predictive value of the balloon test occlusion is the major complicating factor, as it is with balloon occlusion. This technique offers an additional tool that can be used for endovascular occlusion of the carotid or vertebral artery and seems to be less difficult technically. It is our primary technique for parent artery occlusion.
A Multiobjective Evolutionary Algorithm for Tuning Fuzzy Rule Based Systems with Measures for Preserving Interpretability

In this contribution we propose a multi-objective evo- lutionary algorithm for Tuning Fuzzy Rule-Based Systems by consid- ering two objectives, accuracy and interpretability. To this aim we define a new objective that allows preserving the interpretability of the system. This new objective is an interpretability index which is the union of three metrics to preserve the original shapes of the mem- bership functions as much as possible while a tuning of the member- ship function parameters is performed. The proposed method has been compared to a single objective accuracy-guided algorithm in two real problems showing that many solutions in the Pareto front dominate to those obtained by the single objective-based one.
Parametric homogenized model for inclusion of eddy currents and hysteresis in 2-D finite element simulation of electrical machines

Consideration of a fully coupled lamination model with eddy currents and magnetic hysteresis in standard finite element (FE) models is prohibitively expensive in terms of implementation effort, memory requirements and computation time. Hence this paper utilizes an algebraic approximation of the lamination model as a conventional constitutive relationship in two-dimensional FE simulations of rotating electrical machines. Extraction of model structure and parameters of the parametric model as well as iterative adaption of the homogenized FE characteristic are presented. This pragmatic approach turns out to be quite accurate and efficient simultaneously allowing for refinement of the pre-determined parametric expression by iterating between the fully coupled lamination model and the macroscopic model.
Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion

Autophagy is a mechanism by which cells degrade cellular material to provide nutrients and energy for survival during stress. The autophagy is thought to be a critical process for cancer stem cell (CSC) or tumor-initiating cell maintenance but the mechanisms by which autophagy supports survival of CSCs remain poorly understood. In this study, inhibition of autophagy by knockdown of ATG7 or BECN1 modified the CD44+/CD24low/− population in breast cancer cells by regulating CD24 and IL6 secretion. In a breast cancer cell line that is independent of autophagy for survival, autophagy inhibition increased IL6 secretion to the media. On the other hand, in an autophagy-dependent cell line, autophagy inhibition decreased IL6 secretion, cell survival, and mammosphere formation. In these cells, IL6 treatment or conditioned media from autophagy-competent cells rescued the deficiency in mammosphere formation induced by autophagy inhibition. These results reveal that autophagy regulates breast CSC maintenance in autophagy-dependent breast cancer cells by modulating IL6 secretion implicating autophagy as a potential therapeutic target in breast cancer. Implications: Modulation of autophagy in breast cancer has different and even opposite effects, indicating the need for a selection strategy when trying to manipulate autophagy in the context of cancer therapy. Mol Cancer Res; 13(4); 651–8. ©2015 AACR.
Measurement of Soft Magnetic Composite Material Using an Improved 3-D Tester With Flexible Excitation Coils and Novel Sensing Coils

In this paper, accurate measurement of three dimensional (3-D) magnetic properties of soft magnetic composite (SMC) material is carried out by using an improved 3-D tester with adjustable excitation coils and novel sensing coils attached upon the surface of the SMC specimen. Comparing with the conventional 3-D tester operating at 50 Hz, the improved 3-D tester enables measurements over wide frequency range from 2 Hz to 1000 Hz. The relationships between the B vector and H vector are measured under both alternating and rotating flux conditions, and the core loss features are analyzed. These experimental results are crucial for designing new SMC electrical machines, which are expected to operate at 200 Hz or above.
Knowledge, Perception and Experience of Non-consensual Sex among Undergraduate Students of the University of Port-Harcourt, Rivers State, Nigeria.

Non-consensual sex is prevalent across the world and a major public health concern. There is however dearth of information on non-consensual sexual experiences among University undergraduates in River State. This study therefore was designed to document experience of non-consensual sex and its knowledge among undergraduates of the University of Port-Harcourt, Rivers State Nigeria. Three hundred students were purposively selected for the study. A pretested self administered questionnaire was used to collect data on knowledge, perception and experience of non-consensual sex. Data were analyzed using descriptive statistics, and chi-square statistics at 95% significant level. Mean age of respondents was 21.3±2.8years and 97.8% were single. More than half (57.4%) live with their parents. Few had their first sexual intercourse at the age range of 5-9 years. Less than a quarter (16.3%) of the respondents knew that their fathers had ever beaten their mothers. More than a quarter (32.9%) of the respondents were of the view that it is not proper for a man to report if he is forced to have sex by his girl friend, 23.1% were of the view that non-consensual sex is part of relationship so it should be tolerated. Overall majority had good knowledge of non-consensual sex with a mean knowledge score of 2.7±1.7. More female (58.6%) than male (41.4%) had positive perception about non-consensual sex. Twenty-two percent of the respondents agreed that their first sexual experience was non-consensual with 9.0% having their first experience with boyfriend/girlfriend. Knowledge of non-consensual sex was fair and more than half had experienced non-consensual. Health talks during orientation week for both old and new students of the university community should emphasis issues
Nonword Reading Tests: A Review of the Available Resources

Response to Intervention (RTI) models of reading instruction have received much attention in the literature (Fuchs, Mock, Morgan, and Young, 2003; Hosp and Ardoin, 2008; Justice, 2006). Such models call for frequent and high-quality assessment of students' skills. One skill that is vital in the process of learning to read is the ability to sound out letters and blend these sounds together to produce a word. According to Dual Route models of reading (e.g., Coltheart, Rastle, Perry, Langdon, and Ziegler, 2001), these skills comprise the sublexical route to reading. This is best assessed by tests of nonword reading. In this article, 17 tests of nonword reading were reviewed in light of RTI and Dual Route models. The aim of the review was to determine the best available nonword reading tests for use at the Tier One and Tier Two levels of intervention, and the best available nonword reading test for diagnostic (Tier Three) purposes. The review determined that several good-quality tests of nonword reading, suitable for assessing the general functioning of the sublexical route to reading (at the Tier One and Tier Two level), are available, but that no test of nonword reading is available that fulfils all of the desirable criteria for a Tier Three, diagnostic assessment.
Scaled Entropy and DF-SE : Different and Improved Unsupervised Feature Selection Techniques for Text Clustering

Unsupervised feature selection techniques for text data are gaining more and more attention over the last few years. Text data is different from structured data, both in origin and content, and they have some special differentiating properties from other types of data. In this work we analyze some such features and exploit them to propose a new unsupervised feature selection technique called Scaled Entropy. Our experiments on standard corpora show that Scaled Entropy is different from other existing techniques and outperforms them more often than not. We have proposed a technique, inspired by Spearman Rank Correlation Co-efficient [1], for comparing different feature selection methods in terms of selected features. We have shown that the feature selection techniques which are significantly uncorrelated according to this measure, can be combined to produce better hybrid methods. As another contribution of this work, we propose two such hybrid unsupervised feature selection techniques. One of them, combination of Scaled Entropy and Document Frequency, works significantly better than the state-of-theart techniques on standard text clustering corpora.
A novel low cost and easy to fabricate single fed circularly polarized patch antenna

A novel antenna is proposed with a hole through the whole structure that permits to obtain circular polarisation (CP). Parametric studies are done to evaluate the influences of the different parameters. A comparison of performances is then done with a classical CP antenna of same dimensions. An antenna is fabricated to validate the theoretical results and some advantages of this structure are at last given.
RT-HashQ for RTO scheduling

As real-time systems become larger and more complex, attempts to apply the object-oriented paradigm to real-time systems are being made. We introduce a real-time object (RTO) model that is suitable for dynamic real-time environments. We also propose a scheduling algorithm and an implementation of a real-time scheduler for the RTO model. We developed the LLF/MP scheduling algorithm that is good for dynamic real-time environments. A real-time scheduler for the RTO model and LLF/MP scheduling algorithm must guarantee the temporal constraints of both the real-time method and the real-time message, and support an infinite real-time queue efficiently, which LLF/MP needs. To solve these problems, we propose a data structure, RT-HashQ (Real-Time-Hash Queue).
Zeros and poles of transfer functions for linear hybrid systems with periodic jumps

In this paper, we introduce the notion of Transfer Function for linear hybrid systems in the presence of time-driven periodic jumps. It is shown firstly that knowledge of the transfer function permits the computation in closed-form of the complete forced (state or output) response of the hybrid plant. Moreover, hybrid transfer functions resulting from standard interconnection schemes — such as parallel, series and feedback interconnection — are derived. The intrinsically related notions of zero and pole of such transfer function are then discussed in details. Finally, the crucial role played by zeros of a transfer function in the output zeroing is emphasized and extended to the hybrid context.
Selective harmonic elimination for a PV based Quasi — Z Source Inverter for drive systems

This paper deals with simulation analysis of Selective Harmonic Elimination (SHE) for PV operated Quasi Impedance Source Inverter (q-ZSI) drive system. Electricity generation using Photovoltaic cells is a promising form of sustainable energy. A quasi-Z source inverter (q-ZSI) can minimize the power fluctuations from the electric energy generated by a PV panel. In the existing system, during the discharge of energy stored battery Harmonic Distortion is more. The proposed topology describes an improved ability to compensate power while maintaining a constant dc-link peak voltage with minimum harmonics. It is promising to note that the THD level decreases significantly with the introduction of a closed loop controller with Selective Harmonic Elimination technique. Thus the proposed system provides an efficient means of PV power generation.
Effect of Genistein, a Soy Isof lavone, on Whole Body Insulin Sensitivity and Renal Damage Induced by a High-Fructose Diet

The study evaluates the effect of genistein, a soy isoflavone, on insulin sensitivity and renal functional and structural injury in rats rendered insulin-resistant by feeding on a high-fructose diet for 60 days. Fructose-fed animals (60 g /100 g) displayed insulin resistance as indicated by the measures of insulin sensitivity [insulin sensitivity index (ISI0,120), quantitative insulin check index (QUICKI), and homeostatic model assessment (HOMA)]. Alterations in body weight, kidney weight, urine volume, plasma, and urine electrolytes accompanied by significant increases in plasma and urinary levels of urea, uric acid, creatinine, total protein, and albumin were observed in fructose-fed rats. Oxidative stress in kidney was noted by an elevation in lipid peroxides and a decline in glutathione (GSH). Insulin sensitivity and renal function were improved in fructose-fed rats administered genistein. Histological changes such as fatty infiltration and thickening of glomeruli observed in fructose-fed rats were also ameliorated when genistein was co-administered. The study shows that genistein improves insulin sensitivity and kidney function in a dietary model of insulin resistance. We suggest that genistein may have benefits for patients suffering from kidney disease associated with insulin resistance.
Universal path tracing for large-scale sensor networks

Most sensor networks employ dynamic routing protocols so that the routing topology can be dynamically optimized with environmental changes. The routing behaviors can be quite complex with increasing network scale and environmental dynamics. Knowledge on the routing path of each packet is certainly a great help in understanding the complex routing behaviors, allowing effective performance diagnosis and efficient network management. We propose PAT, a universal sensornet path tracing approach. PAT includes an intelligent path encoding scheme that allows efficient decoding at the PC side. To make PAT more scalable, we propose techniques to accurately estimate the degree information by exploiting timing information, allowing more compact path encoding. Moreover, we employ subpath concatenation to infer excessively long paths with a high recovery probability. We carefully evaluate PAT's performance using testbed experiments and and extensive simulations with up to 4,000 nodes. Results show that PAT significantly outperforms existing approaches.