Miracle-dz/UniFAR-FTUs huggingface dataset:
Serelaxin Treatment Reduces Oxidative Stress and Increases Aldehyde Dehydrogenase-2 to Attenuate Nitrate Tolerance

Background: Glyceryl trinitrate (GTN) is a commonly prescribed treatment for acute heart failure patients. However, prolonged GTN treatment induces tolerance, largely due to increased oxidative stress and reduced aldehyde dehydrogenase-2 (ALDH-2) expression. Serelaxin has several vasoprotective properties, which include reducing oxidative stress and augmenting endothelial function. We therefore tested the hypothesis in rodents that serelaxin treatment could attenuate low-dose GTN-induced tolerance. Methods and Results: Co-incubation of mouse aortic rings ex vivo with GTN (10 μM) and serelaxin (10 nM) for 1 h, restored GTN responses, suggesting that serelaxin prevented the development of GTN tolerance. Male Wistar rats were subcutaneously infused with ethanol (control), low-dose GTN+placebo or low-dose GTN+serelaxin via osmotic minipumps for 3 days. Aortic vascular function and superoxide levels were assessed using wire myography and lucigenin-enhanced chemiluminescence assay respectively. Changes in aortic ALDH-2 expression were measured by qPCR and Western blot respectively. GTN+placebo infusion significantly increased superoxide levels, decreased ALDH-2 and attenuated GTN-mediated vascular relaxation. Serelaxin co-treatment with GTN significantly enhanced GTN-mediated vascular relaxation, reduced superoxide levels and increased ALDH-2 expression compared to GTN+placebo-treated rats. Conclusion: Our data demonstrate that a combination of serelaxin treatment with low dose GTN attenuates the development of GTN-induced tolerance by reducing superoxide production and increasing ALDH-2 expression in the rat aorta. We suggest that serelaxin may improve nitrate efficacy in a clinical setting.
Lateral buckling and mechanical stretchability of fractal interconnects partially bonded onto an elastomeric substrate

Fractal-inspired designs for interconnects that join rigid, functional devices can ensure mechanical integrity in stretchable electronic systems under extreme deformations. The bonding configuration of such interconnects with the elastomer substrate is crucial to the resulting deformation modes, and therefore the stretchability of the entire system. In this study, both theoretical and experimental analyses are performed for postbuckling of fractal serpentine interconnects partially bonded to the substrate. The deformation behaviors and the elastic stretchability of such systems are systematically explored, and compared to counterparts that are not bonded at all to the substrate.
Digitization of Free-Swimming Fish Based on Binocular Stereo Vision

With the rapid development of computer vision, the digitization of free-swimming fish has drawn increasing attention. Research on the digitization of fish has many important applications in aquaculture, such as length measurement and species recognition. The aim of digitization of free-swimming fish is acquiring three dimensional point cloud of free-swimming fish and carrying out three-dimension stereo-reconstruction. Calibration and stereo rectification are fulfilled before stereo matching to get intrinsic and extrinsic parameters of cameras and row-aligned image pairs. In order to reduce the effects of non-uniform illumination in the underwater environment, an improved non-local cost aggregation algorithm based on gradient magnitude and phase information is proposed to generate the disparity map in stereo matching step. Then the 3D point cloud of free-swimming fish can be obtained based on triangulation and parallax principle. At last a new way is presented to measure the length of fish by the 3D point cloud of the fish and the error is 5.1% compared with the real length.
Verbally defined processes controlled by fuzzy controllers with input/output parameters represented by set of precise terms

An attempt has been made to explain to the scientific and technical establishment the fact that the fuzzy controllers with input/output parameters represented by set of precise terms automate control objects, whose operative algorithm is presented verbally as a unique experience of experts in the domain, in simpler way, with higher speed, slighter error and less costs as compared with the standard fuzzy controllers.
Whose Album Is This?

We present a method to identify the owner of a photo album taken off a social networking site. We consider this as a problem of prominent person mining. We introduce a new notion of prominent persons, and propose a greedy solution based on an eigenface representation. We mine prominent persons in a subset of dimensions in the eigenface space. We present excellent results on multiple datasets downloaded from the Internet.
Taking advantage of a diffuse medium for high resolution imaging using two antennas

This paper presents a novel imaging method in the microwave range using a random medium. A comparison between three setup configurations is depicted to show the efficacy for radar cross section measurements in an anechoic chamber. By taking advantage of the spectral degrees of freedom provided by the propagation within a multiple scattering medium consisting of a collections of metallic rods and the higher Q-factor provided by a waveguide cavity we image a device under test with only two antennas but a fine resolution. A time reversal method and a matrix inversion method are studied.
Looking Around the Mind’s Eye: Attention-Based Access to Visual Search Templates in Working Memory

We present a new computational model that addresses resource limitations in working memory during visual search. In contrast to previous computational models of visual search, which assume unlimited and instantaneous access to a visual search template stored in working memory, our model provides a new mechanism for sequential, partial access to complex search templates. Using the Embedded Figures Test (EFT) as our task domain, we show that small variations in this mechanism for attention-based template access can have large effects on search performance. We also suggest a new computational explanation for how this mechanism might explain individual differences in “field independence,” the cognitive construct that the EFT is intended to measure. Finally, we discuss the implications of our results for research in AI and cognitive science.
MONITORING SURFACE DEFORMATION IN ACTIVE MARGIN SETTINGS WITH THE SCANSAR TECHNIQUE USING WIDE SWATH ENVISAT DATA

Active continental margins are the Earth's principal regions of active deformation and significant earthquake hazard. We apply the enhanced method called Scan Synthetic Aperture Radar (ScanSAR) interferometry to quantify active surface deformation in the coastal region of the South American active margin in central Chile between 22° S and 27° S. Here, as in other active margin settings, crustal deformation may reach far inland and affects hundreds of square kilometer wide areas. The “normal” ENVISAT ASAR Strip-Mode covers a 100km wide stripe and will therefore not be sufficient for such deformation study. We use the ENVISAT ASAR Wide Swath (WS) data that cover in generally an area of 400x400km². Because of this we investigate the potential of WS data to monitor such wide-stretched surface displacement. Therewith a high spatiotemporal surface deformation monitoring in active margin settings can be given.
Performance characterization of matched subspace detector for spectrum sensing

Matched Subspace Detector (MSD) is a robust detection scheme used for detection of the target primary user signal buried in high-dimensional noise where the target signal is assumed to be placed in low-rank subspace. In this paper we attempt to present the benefits of MSD detector by providing the performance comparison with some other existing blind signal detection techniques and further confirmed detector performance on varying signal dimension and false alarm probabilities. For the scenario when the subspace estimation is done from finite, noisy, signal-bearing training data we propose to use information theoretic criteria (ITC) which highlights the importance of using a critical number of informative components which depends on training phase SNR, system dimension and number of training samples.
Comparative Genomic Hybridization Detects Secondary Chromosomal Deletions in Escherichia coli K-12 MG1655 Mutants and Highlights Instability in the flhDC Region

ABSTRACT The use of whole-genome microarrays for monitoring mutagenized or otherwise engineered genetic derivatives is a potentially powerful tool for checking genomic integrity. Using comparative genomic hybridization of a number of unrelated, directed deletion mutants in Escherichia coli K-12 MG1655, we identified unintended secondary genomic deletions in the flhDC region in Δfnr, Δcrp, and ΔcreB mutants. These deletions were confirmed by PCR and phenotypic tests. Our findings show that nonmotile progeny are found in some MG1655 directed deletion mutants, and studies on the effects of gene knockouts should be viewed with caution when the mutants have not been screened for the presence of secondary deletions or confirmed by other methods.
Specifying the Deployable Software Description Format in XML

Large network environments, such as enterprise Intranets and the Internet, have moved to the center stage in the field of software deployment. The connectivity inherent in these environments provides a new tool that deployment solutions can leverage to perform a comprehensive software deployment life cycle. This life cycle covers a wide range of deployment tasks, including release, install, update, reconfigure, adapt, and remove. But network solutions place a premium on task automation, which requires complete, concise descriptions of the deployment requirements for software systems. The deployment information to be captured for a software system includes its dependencies, constraints, and alternative configurations. This paper presents the Deployable Software Description (DSD) format, a standard schema for describing deployment requirements for the purpose of automating the tasks of the software deployment life cycle. The DSD format is described and compared to other technologies addressing many of the same concerns.
European Conference on Information Systems ( ECIS ) 2000 Glocalizing Trust : The Role of IT in a DeCoupling Industrial District

This paper addresses a specific problem that may arise as consequence of the globalization of the markets. This is the incompatibility between local and global standards of trust. The literature highlights the advantage of co-localization for the production of mutual trust. However, the type of trust produced may be informal and indeed largely incompatible with base of trust in open electronic commerce. This paper focuses on the glocalization of trust, the concurrent development of local and global standards of trust. It has two major goals. Identifying the major factors influencing the local production of global-codified trust. Addressing three alternative strategies local system implements to create compatibility: de-coupling, coupling and loosely coupling. We address some initial evidences in the case of a de-coupling district.
Registration of Remote Sensing Image Data Based on Wavelet Transform

A registration method of remotely sensed image data which is base on the wavelet transform is proposed. The shape information of the regions in the images is analyzed by the Haar and Daubechies’ wavelets. Comparing the coefficients of the wavelets and minimizing the mean square error (MSE) which is defined by the coefficients, the regions are matched and the images are registered. Affine transformation is applied for the registration and its parameters are also determined by the minimum of the MSE. Our result shows that the wavelet method is remarkably stable, irrespective of various shapes of the regions. WG II/IV, III/4, III/5, III/6
Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors

Differentiation is a complex set of events that can be blocked by rearrangements of regulatory genes producing fusion proteins with altered properties. In the case of myxoid liposarcoma (MLS) tumors, the causative abnormality is a fusion between the CHOP transcription factor and the FUS or EWS genes. CHOP belongs to and is a negative regulator of the large CAAT/enhancer binding protein family whose α, β,and δ members are master genes of adipogenesis. Recent clinical data indicate a peculiar sensitivity of these tumors to the natural marine compound trabectedin. One hypothesis is that the activity of trabectedin is related to the inactivation of the FUS-CHOP oncogene. We find that trabectedin causes detachment of the FUS-CHOP chimera from targeted promoters. Reverse transcription-PCR and chromatin immunoprecipitation analysis in a MLS line and surgical specimens of MLS patients in vivo show activation of the CAAT/enhancer binding protein–mediated transcriptional program that leads to morphologic changes of terminal adipogenesis. The activity is observed in cells with type 1 but not type 8 fusions. Hence, the drug induces maturation of MLS lipoblasts in vivo by targeting the FUS-CHOP–mediated transcriptional block. These data provide a rationale for the specific activity of trabectedin and open the perspective of combinatorial treatments with drugs acting on lipogenic pathways. [Mol Cancer Ther 2009;8(2):449–57]
Constructing a Corpus of Japanese Predicate Phrases for Synonym/Antonym Relations

We construct a large corpus of Japanese predicate phrases for synonym-antonym relations. The corpus consists of 7,278 pairs of predicates such as receive-permission (ACC) vs. obtain-permission (ACC), in which each predicate pair is accompanied by a noun phrase and case information. The relations are categorized as synonyms, entailment, antonyms, or unrelated. Antonyms are further categorized into three different classes depending on their aspect of oppositeness. Using the data as a training corpus, we conduct the supervised binary classification of synonymous predicates based on linguistically-motivated features. Combining features that are characteristic of synonymous predicates with those that are characteristic of antonymous predicates, we succeed in automatically identifying synonymous predicates at the high F-score of 0.92, a 0.4 improvement over the baseline method of using the Japanese WordNet. The results of an experiment confirm that the quality of the corpus is high enough to achieve automatic classification. To the best of our knowledge, this is the first and the largest publicly available corpus of Japanese predicate phrases for synonym-antonym relations.
Allocation, Congestion, and the Valuation of Recreational Resources

ing from all aspects of uniqueness, consider N homogeneous recreational resources under atomistic profitmaximizing management. Local alpine ski clubs can serve as an example. All clubs are assumed to be equidistant from a concentrated population of potential users and are identical to one another with respect to hill conditions and facilities. We further assume that skiers have different tastes concerning the effect of other skiers on their enjoyment, though all agree that the satisfaction derived from a visit is diminished, after a point, by the presence of other consumers and that less crowded clubs therefore offer superior skiing. Access to facilities of any club is closed in the sense that the consumer is not admitted until he has paid the set visit price.4 Each club manager is free to choose among n alternative levels of crowding on his facility. Each of these n crowding This content downloaded from 157.55. 39.235 on Fri, 07 Oct 2016 06:04:23 UTC All use subject to http://about.jstor. org/terms
Design of microwave planar directional coupler based on Substrate Integrated Waveguide

Planar directional coupler using Substrate Integrated Waveguide technology (SIW) is proposed i n this paper. The SIW coupler with tapered microstrip-SIW transitions are integrated on the same substrate. Planar form makes this coupler structure easily int egrable in microwave planar circuits. These proposed power divders can be applied to the design of the beam-forming network f or communication system. This structure is designed with Finite Element Method (FEM) using HFSS on a single substrate of ARLON 1000. Sim ulated results are presented and discussed.
Embroidered Electrode with Silver/Titanium Coating for Long-Term ECG Monitoring

For the long-time monitoring of electrocardiograms, electrodes must be skin-friendly and non-irritating, but in addition they must deliver leads without artifacts even if the skin is dry and the body is moving. Today's adhesive conducting gel electrodes are not suitable for such applications. We have developed an embroidered textile electrode from polyethylene terephthalate yarn which is plasma-coated with silver for electrical conductivity and with an ultra-thin titanium layer on top for passivation. Two of these electrodes are embedded into a breast belt. They are moisturized with a very low amount of water vapor from an integrated reservoir. The combination of silver, titanium and water vapor results in an excellent electrode chemistry. With this belt the long-time monitoring of electrocardiography (ECG) is possible at rest as well as when the patient is moving.
The Stability of Planets in the Alpha Centauri System

This paper investigates the long-term orbital stability of small bodies near the central binary of the Alpha Centauri system. Test particles on circular orbits are integrated in the field of this binary for 32 000 binary periods or approximately 2.5 Myr. In the region exterior to the binary, particles with semi-major axes less than roughly three times the binary’s semi-major axis ab are unstable. Inside the binary, particles are unstable if further than 0.2 ab from the primary, with stablility closer in a strong function of inclination: orbits inclined near 90 ◦ are unstable in as close as 0.01 ab from either star.
The Invesment Development Path and the Product Cycle - and Integrated Approach: Empirical Evidence from the new EU member States of CEE

In a globalized environment, where intense competitive pressures constitute the main features, Central and eastern Europe is emerging as a promising investment host region. Following the main lines of Vernon's Produce Life Cycle (PLC), Hirsch's International Trade and Investment Theory of the Firm (ITITF) and Dunning's Investment Development Path (IDP), a theoretical argumentation is synthesized and basic hypotheses are posed and empirically tested. Results demonstrate that these economies are going through the second stage of Dip and confirm a complementary relationship between FDI and Imports as well as the importance of specific location advantages advantages as key determinants of inwards FDI in the region.
Science underpinning the prediction and attribution of extreme events

Introduction Weather and climate-related extreme events have major impacts on human and natural systems, including loss of lives, damage to buildings and other infrastructure, and damage to ecosystems. There are many different types of extreme events, from heat waves, droughts and wild fires to cold outbreaks, flooding, blizzards, storm surges and severe storms. They span a very wide range of temporal scales, from minutes to years, and spatial scales, from a few kilometres to thousands of kilometres. Such extremes are rare in any one location, which increases the difficulty in obtaining robust and reliable observational data and model simulations for extremes.
Sgo1 is a potential therapeutic target for hepatocellular carcinoma

Shugoshin-like protein 1 (Sgo1) is an essential protein in mitosis; it protects sister chromatid cohesion and thereby ensures the fidelity of chromosome separation. We found that the expression of Sgo1 mRNA was relatively low in normal tissues, but was upregulated in 82% of hepatocellular carcinoma (HCC), and correlated with elevated alpha-fetoprotein and early disease onset of HCC. The depletion of Sgo1 reduced cell viability of hepatoma cell lines including HuH7, HepG2, Hep3B, and HepaRG. Using time-lapse microscopy, we showed that hepatoma cells were delayed and ultimately die in mitosis in the absence of Sgo1. In contrast, cell viability and mitotic progression of immortalized cells were not significantly affected. Notably, mitotic cell death induced upon Sgo1 depletion was suppressed upon inhibitions of cyclin-dependent kinase-1 and Aurora kinase-B, or the depletion of mitotic arrest deficient-2. Thus, mitotic cell death induced upon Sgo1 depletion in hepatoma cells is mediated by persistent activation of the spindle assembly checkpoint. Together, these results highlight the essential role of Sgo1 in the maintenance of a proper mitotic progression in hepatoma cells and suggest that Sgo1 is a promising oncotarget for HCC.
Sustained Oxidative Stress Causes Late Acute Renal Failure via Duplex Regulation on p38 MAPK and Akt Phosphorylation in Severely Burned Rats

Background Clinical evidence indicates that late acute renal failure (ARF) predicts high mortality in severely burned patients but the pathophysiology of late ARF remains undefined. This study was designed to test the hypothesis that sustained reactive oxygen species (ROS) induced late ARF in a severely burned rat model and to investigate the signaling mechanisms involved. Materials and Methods Rats were exposed to 100°C bath for 15 s to induce severe burn injury (40% of total body surface area). Renal function, ROS generation, tubular necrosis and apoptosis, and phosphorylation of MAPK and Akt were measured during 72 hours after burn. Results Renal function as assessed by serum creatinine and blood urea nitrogen deteriorated significantly at 3 h after burn, alleviated at 6 h but worsened at 48 h and 72 h, indicating a late ARF was induced. Apoptotic cells and cleavage caspase-3 in the kidney went up slowly and turned into significant at 48 h and 72 h. Tubular cell ROS production shot up at 6 h and continuously rose during the 72-h experiment. Scavenging ROS with tempol markedly attenuated tubular apoptosis and renal dysfunction at 72 h after burn. Interestingly, renal p38 MAPK phosphorylation elevated in a time dependent manner whereas Akt phosphorylation increased during the first 24 h but decreased at 48 h after burn. The p38 MAPK specific inhibitor SB203580 alleviated whereas Akt inhibitor exacerbated burn-induced tubular apoptosis and renal dysfunction. Furthermore, tempol treatment exerted a duplex regulation through inhibiting p38 MAPK phosphorylation but further increasing Akt phosphorylation at 72 h postburn. Conclusions These results demonstrate that sustained renal ROS overproduction induces continuous tubular cell apoptosis and thus a late ARF at 72 h after burn in severely burned rats, which may result from ROS-mediated activation of p38 MAPK but a late inhibition of Akt phosphorylation.
IBuilding Web/Commodity based Visual Authoring Environments for Distributed Object/Component Applications - A Case Study using NPAC WebFlow System

Summary We present here an approach towards visual authoring environments for Web/Commodity based distributed object/omponentwarecomputing using the WebFlow system under development at NPAC as a case study. WebFlow is a 3-tier Java based visual dataﬂowsystem with applets based authoring, visualization and control front-ends, and with servlets based middleware management ofbackend modules that wrap legacy codes such as databases or high performance simulations. We summarize here the WebFlowarchitecture, we describe a set of demos and early applications in various areas of distributed computing (including imaging, col-laboration, condensed matter physics and military wargaming simulations), and we outline the next phase design, based on lesson slearned in the current prototype. New WebFlow uses JWORB (Java Web Object Request Broker) middleware and employsWOMA (Web Object Management Architecture) methodology to establish a testbed for testing, evaluating and integrating theemergent componentware standards of CORBA, DCOM, Java and W3C/WOM.