Miracle-dz/UniFAR-FTUs huggingface dataset:
Letter to the Editor concerning “Cross-Cultural Adaptation and Validation of the Arabic Version of the Intermittent and Constant Osteoarthritis Pain

An interesting paper was recently published regarding the translation and validation of the Intermittent and Constant Osteoarthritis Pain (ICOAP) questionnaire into the Arabic language [1]. The procedures described in the manuscript are clear and follow the recommended guidelines for appropriate translation of a self-reported measurement scale [2]. However, upon critical scrutiny of the paper we found some critical issues that would significantly hamper correct understanding of the translated version and, hence, its reported psychometric properties.
Associations of herbal and specialty supplements with lung and colorectal cancer risk in the VITamins And Lifestyle (VITAL) Study

Millions of Americans use dietary supplements with little knowledge about their benefits or risks. We examined associations of various herbal/specialty supplements with lung and colorectal cancer (CRC) risk. Men and women, 50-76y, in the VITAL (VITamins And Lifestyle) cohort completed a 24-page baseline questionnaire that captured duration (years) and frequency (days/week) of use of commonly used herbal/specialty supplements. Dose was not assessed due to lack of accurate potency information. Supplement exposure was categorized as “no use” or “any use” over the previous 10 years. Hazard ratios (HR) were estimated by multivariate Cox regression models. Incident lung (n=665) and CRC cancers (n=428) were obtained from the SEER cancer registry. Any use of glucosamine and chondroitin, which have anti-inflammatory properties, over the previous 10 years, was associated with significantly lower lung cancer risk: HR: 0.74 (95% CI: 0.58, 0.94) and HR: 0.72 (95% CI: 0.54, 0.96) and CRC risk: HR: 0.73 (95% CI: 0.54, 0.98) and HR: 0.65 (95% CI: 0.45, 0.93), respectively. There were also statistically significantly inverse associations of fish oil: HR: 0.65 (95% CI: 0.42, 0.99), methylsulfonylmethane (MSM): HR: 0.46 (95% CI: 0.23, 0.93), and St. John's wort: HR: 0.35 (95% CI: 0.14, 0.85) with CRC risk. In contrast, garlic pills were associated with a statistically significant 35% elevated CRC risk. These results suggest that some herbal/ specialty supplements may be associated with lung and CRC risk; however, these products should be used with caution. Additional studies examining the effects of herbal/specialty supplements on risk for cancer/other diseases are needed.
A high-throughput method for measuring critical thermal limits of 1 leaves by chlorophyll imaging fluorescence 2 3

6 1 Division of Ecology and Evolution, Research School of Biology, The Australian National 7 University, Canberra, ACT, Australia 8 2 Department of Agronomical Sciences and Natural Resources, Faculty of Agropecuary and 9 Forestry Sciences & Center of Plant, Soil Interaction and Natural Resources Biotechnology, 10 Scientific and Technological Bioresource Nucleus, Universidad de La Frontera, Casilla 54D, 11 Temuco, Chile 12
Food intake of individuals with and without diabetes across different countries and ethnic groups

Epidemiology Section, Institute for Experimental Medicine, Christian-Albrechts-University of Kiel, Kiel, Germany; Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA; Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark; Department of Cardiology, Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aarhus, Denmark; Department of Epidemiology, School of Public Health, Aarhus University, Aarhus, Denmark; Public Health Division of Gipuzkoa, Basque Government, CIBERSP, Ciber en Epidemioogia y Salud Publica, Barcelona, Spain; Public Health Institute of Navarra, Pamplona, Spain; Department of Preventive Medicine and Quality Management. Hospital Virgen del Camino, Pamplona, Spain; Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain; Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute— ISPO, Florence, Italy; Nutritional Epidemiology Unit, IRCCS Istituto Nazionale Tumori, Milan, Italy; Cancer Registry and Histopathology Unit, ‘Civile M.P. Arezzo’ Hospital, Ragusa, Italy; CPO-Piemonte Torino and Human Genetics Foundation, Torino, Italy; Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands; National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands; Department of Clinical Sciences—Malmo, Lund University, Malmo, Sweden; Department of Clinical Sciences in Malmo, Nutrition Epidemiology, Lund University, Malmo, Sweden; Department of Public Health and Clinical Medicine, Family Medicine, Umea University Hospital, Umea, Sweden; Genetic Epidemiology and Clinical Research Group, Section for Medicine, Department Public Health and Clinical Medicine, Umea University Hospital, Umea, Sweden; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skane University Hospital, Lund University, Malmo, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA and Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
Transcriptome Analysis of xa5-mediated Resistance to Bacterial Leaf Streak in Rice (Oryza sativa L.)

Bacterial leaf steak (BLS) caused by Xanthomonas oryzae pv. oryzicola (Xoc) is a devastating disease in rice production. The resistance to BLS in rice is a quantitatively inherited trait, of which the molecular mechanism is still unclear. It has been proved that xa5, a recessive bacterial blast resistance gene, is the most possible candidate gene of the QTL qBlsr5a for BLS resistance. To study the molecular mechanism of xa5 function in BLS resistance, we created transgenic lines with RNAi of Xa5 (LOC_Os05g01710) and used RNA-seq to analyze the transcriptomes of a Xa5-RNAi line and the wild-type line at 9 h after inoculation with Xoc, with the mock inoculation with water as control. The results showed that Xa5-RNAi could (1) increase the resistance to BLS as expected from xa5; (2) alter (mainly up-regulate) the expression of hundreds of genes, most of which were related to disease resistance; and (3) greatly enhance the response of thousands of genes to Xoc infection, especially of the genes involved in cell death pathways, suggesting that xa5 displays BLS resistance effect probably mainly because of the enhanced response of the cell death-related genes to Xoc infection.
Influence of Residency Training on Research Productivity and Plastic Surgery Career

Background The impact of residency training on academic productivity and a career in academic plastic surgery remains uncertain. Previous literature has explored the influence of training institutions on academic careers in surgery. The aims of the study were to assess research productivity during plastic surgery residency training and to illustrate how differences in training programs impact resident research productivity. Methods Academic plastic surgery faculty that graduated in the past 10 years were identified through an Internet search of all Accreditation Council for Graduate Medical Education–accredited residency and fellowship training programs. Research productivity was compared based on h-index, number, and quality of peer-reviewed articles published during residency. Results Three hundred seventy-five academic plastic surgeons were identified and produced 2487 publications during residency. The 10 most productive training institutions were Johns Hopkins, Georgetown, University of Michigan, Stanford, University of California Los Angeles, Northwestern, Harvard, New York University, University of Pennsylvania, and Baylor. Academic productivity was higher among integrated residents (integrated = 8.68 publications, independent = 5.49 publications, P < 0.0001). The number of publications positively correlated to faculty size (r = 0.167, P = 0.0013), National Institute of Health (NIH) funding (r = 0.249, P < 0.0001), residency graduation year (r = 0.211, P < 0.0001), and negatively correlated with Doximity ranking (r = −0.294, P < 0.0001). H-index was positively correlated with number of publications (r = 0.622, P < 0.0001), faculty size (r = 0.295, P < 0.0001), and NIH funding (r = 0.256, P < 0.0001) and negatively correlated with Doximity ranking (r = −0.405, P < 0.0001) and residency graduation year (r = −0.163, P < 0.0001). Conclusions Our study has found that there is an elite cohort of programs that are the most productive research institutions. Resident research productivity is higher among integrated residents, recent graduates, and programs that are larger in size, with a higher Doximity ranking and NIH funding. This study can guide medical students and future applicants who are interested in a career in academic plastic surgery in the selection of programs that match their career aspirations.
Genetic Properties of the Maize Nested Association Mapping Population

Codifying Maize Modifications Maize, one of our most important crop species, has been the target of genetic investigation and experimentation for more than 100 years. Crossing two inbred lines tends to result in “better” offspring, in a process known as heterosis. Attempts to map the genetic loci that control traits important for farming have been made, but few have been successful (see the Perspective by Mackay). Buckler et al. (p. 714) and McMullen et al. (p. 737) produced a genomic map of maize that relates recombination to genome structure. Even tremendous adaptations in very diverse species were produced by numerous, small additive steps. Differences in flowering time in maize among inbred lines were not caused by a few genes with large effects, but by the cumulative effects of numerous quantitative trait loci—each of which has only a small impact on the trait. Outcrossing vigor in maize is most likely due to retained variability in regions around the centromeres. Maize genetic diversity has been used to understand the molecular basis of phenotypic variation and to improve agricultural efficiency and sustainability. We crossed 25 diverse inbred maize lines to the B73 reference line, capturing a total of 136,000 recombination events. Variation for recombination frequencies was observed among families, influenced by local (cis) genetic variation. We identified evidence for numerous minor single-locus effects but little two-locus linkage disequilibrium or segregation distortion, which indicated a limited role for genes with large effects and epistatic interactions on fitness. We observed excess residual heterozygosity in pericentromeric regions, which suggested that selection in inbred lines has been less efficient in these regions because of reduced recombination frequency. This implies that pericentromeric regions may contribute disproportionally to heterosis.
Ovid: US Physicians' Work Motivation and Their Occupational Health: A National Survey of Practicing Physicians

Page 1 of 15 https://ovidsp-dc2-ovid-com.ezp. lib.rochester. edu/sp-3.33. 0b/ovidweb.cgi [Original Articles] Medical Care Issue: Volume 57(5), May 2019, p 334-340 Copyright: Copyright (C) 2019 Wolters Kluwer Health, Inc. All rights reserved. Publication Type: [Original Articles] DOI: 10.1097/MLR.0000000000001101 ISSN: 0025-7079 Accession: 00005650-201905000-00003
Predicting Regional‐Scale Soil Variability using a Single Calibrated Apparent Soil Electrical Conductivity Model

Multi-field/multi-season approaches used to calibrate apparent soil electrical conductivity (EC a ) models for predicting soil spatial variability across large landscapes are time-consuming. In this study an alternative calibration approach was evaluated. The study was conducted on an agricultural watershed in Texas with the objectives of (i) assessing the contribution of different soil properties to EC a variability; and (ii) evaluating the feasibility of using a single calibration approach to predict soil variability across different fields. Of the soil properties measured, clay content contributed the greatest to EC a variability. The single calibration approach was used to calibrate an EC a -clay model using data from a designated calibration area (CA). When the calibrated model was used to predict clay content in four validation fields, prediction accuracies were between 2 and 4% clay. Accuracies were comparable with other methods indicating that the single-calibration approach was a suitable alternative to multi-field/multi-season calibration approaches.
Seasonal Phytoplankton Dynamics in the Eastern Tropical Atlantic

The coastal zone color scanner (CZCS) that operated aboard the Nimbus 7 satellite provided extensive coverage of phytoplankton pigment concentrations in the surface waters of the eastern tropical Atlantic (ETA) from March 1979 to February 1980 and coincided with four major research cruises to this region. Total primary production within the ETA (5°N–10°S, 25°W–10°E) was determined from CZCS pigment estimates and an empirical algorithm derived from concurrent in situ data taken along 4°W that relates near-surface chlorophyll concentration and integrated primary production. We estimated an average annual production for the ETA of 2.3 Gt C yr−1 with an associated 3.5-fold seasonal variation in the magnitude of this production. We describe the principal physical mechanisms controlling seasonal phytoplankton dynamics within the ETA and propose that in addition to seasonal change in the thermocline depth, one must also consider changes in the depth of the equatorial undercurrent. An extensive validation effort indicates that the standard CZCS global products are a conservative estimate of pigment concentrations in ETA surface waters. Significant underestimates by the CZCS global products were observed in June and July which we attributed, in part, to aerosol correction errors and, more importantly, to errors caused by a significant reduction in the concentration of near-surface dissolved organic matter that resulted from strong equatorial upwelling.
Bezafibrate improves insulin sensitivity and metabolic flexibility in STZ-treated diabetic mice

Bezafibrate (BEZ), a pan activator of peroxisome proliferator-activated receptors (PPARs), has been generally used to treat hyperlipidemia for decades. Clinical trials with type 2 diabetes patients indicated that BEZ also has beneficial effects on glucose metabolism, although the underlying mechanisms of these effects remain elusive. Even less is known about a potential role for BEZ in treating type 1 diabetes. Here we show that BEZ markedly improves hyperglycemia and glucose and insulin tolerance in streptozotocin (STZ)-treated mice, an insulin-deficient mouse model of type 1 diabetes. BEZ treatment of STZ mice significantly suppressed the hepatic expression of genes that are annotated in inflammatory processes, whereas the expression of PPAR and insulin target gene transcripts was increased. Furthermore, BEZ-treated mice also exhibited improved metabolic flexibility as well as an enhanced mitochondrial mass and function in the liver. Finally, we show that the number of pancreatic islets and the area of insulin positive cells tended to be higher in BEZ-treated mice. Our data suggest that BEZ may improve impaired glucose metabolism by augmenting hepatic mitochondrial performance, suppressing hepatic inflammatory pathways, and improving insulin sensitivity and metabolic flexibility. Thus, BEZ treatment might also be useful for patients with impaired glucose tolerance or diabetes. proliferator-activated glutamate and as in of with data demonstrated that
Studies on Monitoring and Tracking Genetic Resources: An Executive Summary

The principles underlying fair and equitable sharing of benefits derived from the utilization of genetic resources are set out in Article 15 of the UN Convention on Biological Diversity, which stipulate that access to genetic resources is subject to the prior informed consent of the country where such resources are located and to mutually agreed terms regarding the sharing of benefits that could be derived from such access. One issue of particular concern for provider countries is how to monitor and track genetic resources once they have left the provider country and enter into use in a variety of forms. This report was commissioned to provide a detailed review of advances in DNA sequencing technologies, as those methods apply to identification of genetic resources, and the use of globally unique persistent identifiers for persistently linking to data and other forms of digital documentation that is linked to individual genetic resources. While the report was written for an audience with a mixture of technical, legal, and policy backgrounds it is relevant to the genomics community as it is an example of downstream application of genomics information.
An evaluation metric for multiple camera tracking systems: the i-LIDS 5th scenario

The Imagery Library for Intelligent Detection Systems (i-LIDS) is the UK government's standard for Video Based Detection Systems (VBDS). The Home Office Scientific Development Branch (HOSDB) in partnership with the Centre for the Protection of National Infrastructure (CPNI) has now developed a fifth i-LIDS Scenario; Multiple Camera Tracking (MCT). The imagery contains various staged events of people walking through the camera views. A bounding box Ground Truth is provided with the imagery. A metric has been developed by HOSDB for evaluation of systems. The metric is based on precision and recall system output compared to the ground truth.
Cortical network fingerprint and prediction of deep brain stimulation-induced speech impairment in essential tremor

Thalamic deep brain stimulation (DBS) is an effective treatment for patients with medically refractory essential tremor. However, stimulation-induced side-effects, especially stimulationinduced dysarthria (SID), interfere severely with quality of life and postoperative tremor control. Here, we present a functional and structural network approach to SID to gain insights into the associated brain areas and to predict stimulation-induced worsening of intelligibility. Monopolar reviews were conducted in 14 essential tremor patients with bilateral thalamic DBS by increasing the stimulation amplitude contact-wise until (i) a maximum of 10mA, (ii) the occurrence of intolerable side effects, or (iii) the onset of SID. Speech assessments included intelligibility ratings when reading a German standard text and a fast syllable repetition task. To detect brain areas associated with SID, a functional connectivity difference image of volumes of tissue activated (VTAs) causing SID, and VTAs not causing SID was created employing a state-of-the-art functional connectome, Lead-DBS, as well as the SPM toolbox. Additionally, discriminative fibers for stimulation-induced worsening of intelligibility were identified in a structural connectome using linear mixed effect models and validated in a leaveone-out design. A total of 111 contact assessments were included for further analysis. The functional connectivity difference image indicated stronger connectivity of VTAs causing SID (N = 51) to the precentral gyrus with a positive medio-lateral gradient, parts of the inferior and medial frontal gyrus, the supramarginal gyrus, the superior temporal gyrus, as well as the superior and the inferior cerebellar lobules, and the vermis. In the thalamic region, discriminative fibers for stimulation-induced worsening of intelligibility were located anterolaterally to fibers associated with tremor control as published by Al-Fatly et al. (2019). The overlap of the respective clinical stimulation setting’s VTAs with these fibers explained 33.2% of the variance of individual change in intelligibility compared to “OFF stimulation” in a leaveone-out design. This study demonstrates that SID in essential tremor patients is related to a modulation of the functional connectome of speech production by thalamic DBS. In spite of the Running head: Networks in DBS-induced dysarthria proximity of functional and structural connectivity patterns for tremor control, as identified by Al-Fatly et al. (2019), and deterioration of speech, as identified in the present study, we were able to derive a fiber-based atlas structure, that could help to avoid SID in essential tremor patients. These findings might contribute to future lead placement and postoperative programming strategies.
Percutaneous Transvalvular Microaxial Flow Pump Support in Cardiology

The Impella device (Impella, Abiomed, Danvers, MA) is a percutaneous transvalvular microaxial flow pump that is currently used for (1) cardiogenic shock, (2) left ventricular unloading (combination of venoarterial extracorporeal membrane oxygenation and Impella concept), (3) high-risk percutaneous coronary interventions, (4) ablation of ventricular tachycardia, and (5) treatment of right ventricular failure. Impella-assisted forward blood flow increased mean arterial pressure and cardiac output, peripheral tissue perfusion, and coronary blood flow in observational studies and some randomized trials. However, because of the need for large-bore femoral access (14 F for the commonly used Impella CP device) and anticoagulation, the incidences of bleeding and ischemic complications are as much as 44% and 18%, respectively. Hemolysis is reported in as many as 32% of patients and stroke in as many as 13%. Despite the rapidly growing use of the Impella device, there are still insufficient data on its effect on outcome and complications on the basis of large, adequately powered randomized controlled trials. The only 2 small and also underpowered randomized controlled trials in cardiogenic shock comparing Impella versus intra-aortic balloon pump did not show improved mortality. Several larger randomized controlled trials are currently recruiting patients or are in preparation in cardiogenic shock (DanGer Shock [Danish-German Cardiogenic Shock Trial; NCT01633502]), left ventricular unloading (DTU-STEMI [Door-To-Unload in ST-Segment–Elevation Myocardial Infarction; NCT03947619], UNLOAD ECMO [Left Ventricular Unloading to Improve Outcome in Cardiogenic Shock Patients on VA-ECMO], and REVERSE [A Prospective Randomised Trial of Early LV Venting Using Impella CP for Recovery in Patients With Cardiogenic Shock Managed With VA ECMO; NCT03431467]) and high-risk percutaneous coronary intervention (PROTECT IV [Impella-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function; NCT04763200]).