Miracle-dz/UniFAR-FTUs huggingface dataset:
Microarray Analyses Uncover UBE1L as a Candidate Target Gene for Lung Cancer Chemoprevention

Retinoids, natural and synthetic derivatives of vitamin A, are active in cancer therapy and chemoprevention. We reported previously that all-trans-retinoic acid (RA) treatment prevented carcinogen-induced transformation of immortalized human bronchial epithelial (HBE) cells. To identify cancer chemopreventive mechanisms, immortalized (BEAS-2B), carcinogen-transformed (BEAS-2BNNK), and RA-chemoprevented (BEAS-2BNNK/RA) HBE cells were used to conduct microarray analyses independently. Species increased in chemoprevented as compared with immortalized HBE cells (group I) and those augmented in chemoprevented as compared with transformed HBE cells (group II) included known RA-target genes as well as previously unrecognized RA-target genes in HBE cells. Unexpectedly, both groups were also enriched for interferon-stimulated genes. One interferon-stimulated gene of particular interest was UBE1L, the ubiquitin-activating enzyme E1-like protein. UBE1L expression was also induced after prolonged RA-treatment of immortalized HBE cells. UBE1L mRNA was shown previously as repressed in certain lung cancer cell lines, directly implicating UBE1L in lung carcinogenesis. Notably, UBE1L immunoblot expression was reduced in a subset of malignant as compared with adjacent normal lung tissues that were examined. Immunohistochemical analyses were performed using a new assay developed to detect this species using rabbit polyclonal anti-UBE1L antibodies independently raised against the amino- or carboxyl-termini of UBE1L. Studies done on paraffin-embedded and fixed tissues revealed abundant UBE1L, but low levels of cyclin D1 expression in the normal human bronchial epithelium, indicating an inverse relationship existed between these species. To study this further, cotransfection into HBE cells of wild-type or mutant UBE1L species was accomplished. In a dose-dependent manner, wild-type but not mutant UBE1L species repressed cyclin D1 expression. This implicated UBE1L in a retinoid chemoprevention mechanism involving cyclin D1 repression described previously. Taken together, these findings directly implicate UBE1L as a candidate-pharmacologic target for lung cancer chemoprevention. These findings also provide a mechanistic basis for the tumor suppressive effects of UBE1L through cyclin D1 repression.
What's in a Word? On Weight Stigma and Terminology

In 2015, the 3rd Annual International Weight Stigma Conference was held in Reykjavik, Iceland.1 One of the highly anticipated sessions of the 2-day event was a roundtable discussion on terminology used in weight stigma research and professional practice to describe higher-weight bodies and to identify best practice—how to engage in the conversation without being part of the problem. We tried to include a range of voices on the panel, including weight stigma researchers from health and social sciences, a bioethicist, a journal editor, a representative of an obesity organization, and a size-acceptance activist. At the end of the hour, the only thing that everybody agreed on was that there was no simple answer, other than to respect and honor the wishes of the person or people we were speaking to or about in any given situation.
Impact of heat stress on egg quality in layer hens supplemented with l-ascorbic acid and dl-tocopherol acetate.

The aim of the experiment was to investigate the effects of heat stress on egg quality profi le in layer hens supplemented with vitamins C and E. A total of 720 L33 layer hens at 39 weeks old, were divided into four groups of 180 birds. One group was fed a basal diet (control) and treatment groups were fed a basal diet supplemented with 150 mg of l-ascorbic acid/kg of diet (Vit. C group), 150 mg of α-dl-tocopherol acetate/kg of diet (Vit. E group), while the last group was supplemented with 150 mg of l-ascorbic acid/kg of diet plus 150 mg of α-dl-tocopherol acetate/kg of diet (Vit C + E group). Egg, albumen and eggshell weights were higher (P<0.05) and (P<0.005) in vitamins E and C + E groups when compared to vitamin C and control groups. Egg yolk was higher (P<0.05), (P<0.005) and (P<0.0005) in the vitamin C + E group, compared to the vitamin E and vitamin C treated groups and control respectively. Egg shell thickness, egg resistance and specifi c gravity showed (P<0.05) and (P<0.005) in the vitamins C + E group, compared to the vitamin C and E groups, and control. Haugh Unit was higher (P<0.05) and (P<0.005) in the vitamins C + E treated group compared to vitamin C and E treated groups, and control. The results suggest that the supplementation of antioxidant vitamins had a benefi cial effect on egg quality in heat stressed layer hens.
Ear Authentication and Template Protection using Bio-key

Biometric authentication is gaining popularity in the current scenario. Biometric based authentication is the science of using physical or behavioral characteristic for ensuring that the person is the claimed identity. Biometric authentication system is also vulnerable to attacks in various phases. The biometric data stored in the template has to be protected, since variety of attacks like circumvent, covert acquisition affects the normal functioning of the system. An attacker may create new biometric data or steal the template or modify the template. Once the biometric template is compromised then the entire system is lost. So securing biometric template is an important aspect in biometric authentication system. In this study ear biometric template is secured by a new method of generating bio key from the ear fused template. Here the transformed template is stored in the database. During verification phase, for the new biometric sample a bio key is generated. Using this bio key the person is authenticated if the transformed feature generated is matched with the stored one. Hence the template is protected with the bio key. The authenticated person alone can access the system, since the key to decrypt the encrypted template is obtained from the ear trait of the authenticated person. FAR and FRR are used to evaluate the system performance.
On the conditioning channel capacity of MIMO two-way relay networks against eavesdropper

In this paper, we consider the two-way relay network (TWRN) in the presence of an eavesdropper, and construct a noisy amplify-and-forward (AF) algorithm to enhance the physical (PHY) layer security capacity. All the source nodes, the relay and the eavesdropper are equipped with multiple antennas. In the proposed noisy AF scheme, the relay first receives signals from both source nodes, adds weighted artificial noise (AN), and then amplifies and forwards the modified signal to both source nodes. In this scenario, we analyze the effects of AN and the number of relay antennas on the secrecy sum rate for different conditioning channel matrices. It is shown that AN will result in an increased secrecy sum rate, and the channel condition is a key parameter of the system in deciding the sum secrecy rate. Finally, simulation results demonstrate the validity of proposed studies.
Modeling and Instability of Average Current Control

Dynamics and stability of average current control of DC-DC converters are analyzed by sampled-data modeling. Orbital stability is studied and it is found unrelated to the ripple size of the orbit. Compared with the averaged modeling, the sampled-data modeling is more accurate and systematic. An unstable range of compensator pole is found by simulations, and is predicted by sampled-data modeling and harmonic balance modeling.
Grindžiamosios teorijos tyrimo priemonių sudarymas: procesas, parametrai ir rezultatai

Anotacija. Straipsnyje aprašomas grindžiamosios teorijos tyrimo priemonių sudarymas: analizuojant skirtingas grindžiamosios teorijos atmainas, apibūdinamas procesas, pagrindiniai parametrai ir siekiami rezultatai. Nepaisant tam tikrų metodologinių skirtumų tarp įvairių GT atmainų, esminis akcentas aptariant priemonių sudarymą yra judumas ir priemonių kintamumas. Viena vertus, šios ypatybės praplečia tyrėjo galimybes, kita vertus, susiduriama su informacijos perkrova, kurią tyrėjui tampa sudėtinga suvaldyti.
Dopamine Modulates Spike Timing-Dependent Plasticity and Action Potential Properties in CA1 Pyramidal Neurons of Acute Rat Hippocampal Slices

Spike timing-dependent plasticity (STDP) is a cellular model of Hebbian synaptic plasticity which is believed to underlie memory formation. In an attempt to establish a STDP paradigm in CA1 of acute hippocampal slices from juvenile rats (P15–20), we found that changes in excitability resulting from different slice preparation protocols correlate with the success of STDP induction. Slice preparation with sucrose containing ACSF prolonged rise time, reduced frequency adaptation, and decreased latency of action potentials in CA1 pyramidal neurons compared to preparation in conventional ASCF, while other basal electrophysiological parameters remained unaffected. Whereas we observed prominent timing-dependent long-term potentiation (t-LTP) to 171 ± 10% of controls in conventional ACSF, STDP was absent in sucrose prepared slices. This sucrose-induced STDP deficit could not be rescued by stronger STDP paradigms, applying either more pre- and/or postsynaptic stimuli, or by a higher stimulation frequency. Importantly, slice preparation with sucrose containing ACSF did not eliminate theta-burst stimulation induced LTP in CA1 in field potential recordings in our rat hippocampal slices. Application of dopamine (for 10–20 min) to sucrose prepared slices completely rescued t-LTP and recovered action potential properties back to levels observed in ACSF prepared slices. Conversely, acute inhibition of D1 receptor signaling impaired t-LTP in ACSF prepared slices. No similar restoring effect for STDP as seen with dopamine was observed in response to the β-adrenergic agonist isoproterenol. ELISA measurements demonstrated a significant reduction of endogenous dopamine levels (to 61.9 ± 6.9% of ACSF values) in sucrose prepared slices. These results suggest that dopamine signaling is involved in regulating the efficiency to elicit STDP in CA1 pyramidal neurons.
Possible Therapeutic Effect of Stem Cell in Atherosclerosis in Albino Rats. A Histological and Immunohistochemical Study

Background Atherosclerosis is the leading cause of death worldwide. there are no effective approaches to regressing atherosclerosis due to not fully understood mechanisms. Recently, stem cell-based therapies have held promises to various diseases, including vascular diseases. Aim The present study aimed at investigating the possible effect of cord blood mesenchymal stem cell (MSC) therapy on atherosclerosis. Material and Methods Eighty adult male albino rats were divided into control group (I), atherogenic group (II): subjected to high cholesterol fed diet (200~300 mg/kg body weight) for 12 weeks and 1.8 million units of vitamin D / kg of diet for 6 weeks. Stem cell therapy group (III): injected with stem cells in the tail vein following confirmation of atherosclerosis. Histological, Immunohistochemical and morphometric studies were performed were conducted. Results Atherogenic group (II) showed increased aortic thickness, intimal proliferation, smooth muscle proliferation and migration. Increased area % of collagen fibers, iNOS and vimentin immunoreactions were recorded and proved morphometrically. All findings regressed on stem cell therapy. Conclusion A definite therapeutic effect of mesenchymal stem cells was found on atherosclerosis.
Psychodynamic Improvement in Eating Disorders: Welcoming Ignored, Unspoken, and Neglected Concerns in the Patient to Foster Development and Resiliency

ABSTRACT Drawing upon case examples from their clinical, supervisory, and teaching experience, the authors suggest eating disorder treatment that primarily addresses behavioral change and is relatively short term leaves many patients behind in the search for a fuller sense of self and resilience. They have found that improvement rests upon ferreting out developmental deficits and other factors in early life that have been ignored, unspoken, and neglected; and without reflecting on, working through, and integrating these early experiences patients feel a part of themselves is still missing after symptom reduction. The authors assert that longer-term psychodynamic treatment facilitates therapeutic improvement by addressing six major domains: 1) mitigation of shame; 2) integration of split off affects and defenses; 3) achievement of greater intimacy and/or capacity to play; 4) confrontation of the tendency to spoil forward movement and self-sabotage; 5) identification with benign introjects and amelioration of a primitive, highly punitive superego; and 6) recognition and confrontation of denial of death. By describing the benefits of longer-term work with eating disorder patients, the authors hope to encourage others to expand the knowledge base of what constitutes therapeutic improvement and resilience, leading to lives that that are fuller, more creative, and productive.
Active Learning with Committees in Text Categorization: Preliminary Results in Comparing Winnow and Perceptron

The availability of vast amounts of information on the World Wide Web has created a big demand for automatic tools to organize and index that information. Unfortunately, the paradigm of supervised machine learning is ill-suited to this task, as it assumes that the training examples are classified by a teacher ‐ usually a human. In this paper, we describe an active learning method based on Query by Committee (QBC) that reduces the number of labeled training examples (text documents) required for learning by 1-2 orders of magnitude.
Association Mapping of Seed Oil and Protein Content in Sesamum indicum L. Using SSR Markers

Sesame is an important oil crop for the high oil content and quality. The seed oil and protein contents are two important traits in sesame. To identify the molecular markers associated with the seed oil and protein contents in sesame, we systematically performed the association mapping among 369 worldwide germplasm accessions under 5 environments using 112 polymorphic SSR markers. The general linear model (GLM) was applied with the criteria of logP≥3.0 and high stability under all 5 environments. Among the 369 sesame accessions, the oil content ranged from 27.89%–58.73% and the protein content ranged from 16.72%–27.79%. A significant negative correlation of the oil content with the protein content was found in the population. A total of 19 markers for oil content were detected with a R2 value range from 4% to 29%; 24 markers for protein content were detected with a R2 value range from 3% to 29%, of which 19 markers were associated with both traits. Moreover, partial markers were confirmed using mixed linear model (MLM) method, which suggested that the oil and protein contents are controlled mostly by major genes. Allele effect analysis showed that the allele associated with high oil content was always associated with low protein content, and vice versa. Of the 19 markers associated with oil content, 17 presented near the locations of the plant lipid pathway genes and 2 were located just next to a fatty acid elongation gene and a gene encoding Stearoyl-ACP Desaturase, respectively. The findings provided a valuable foundation for oil synthesis gene identification and molecular marker assistant selection (MAS) breeding in sesame.
Attack Pattern-Based Combinatorial Testing with Constraints for Web Security Testing

Security testing of web applications remains a major problem of software engineering. In order to reveal vulnerabilities, manual and automatic testing approaches use different strategies for detection of certain kinds of inputs that might lead to a security breach. In this paper we compared a state-of-the-art manual testing tool with an automated one that is based on model-based testing. The first tool requires user input from the tester whereas the second one reduces the necessary amount of manual manipulation. Both approaches depend on the corresponding test case generation technique and its produced inputs are executed against the system under test (SUT). For this case we enhance a novel technique, which combines a combinatorial testing technique for input generation and a model-based technique for test execution. In this work the input parameter modelling is improved by adding constraints to generate more comprehensive and sophisticated testing inputs. The evaluated results indicate that both techniques succeed in detecting security leaks in web applications with different results, depending on the background logic of the testing approach. Last but not least, we claim that attack pattern-based combinatorial testing with constraints can be an alternative method for web application security testing, especially when we compare our method to other test generation techniques like fuzz testing.
An ultra-low power CMOS PTAT current source

A low-voltage, ultra-low-power sub-threshold proportional to absolute temperature (PTAT) current source is proposed. The new topology generates the PTAT current from the ratio between the drain currents of two transistors in subthreshold operation. Linearity is analyzed and a compensation strategy to improve it is developed. This is the first time such a design scheme is presented. Total current drain for the circuit is approximately 3.8 ? A with a minimum supply voltage of 1 V and a PSRR greater than 50 dB at room temperature. The linear range is at least from ? 40 ? C to 125 ? C. The performance of the proposed reference is compared with several existing designs.
DynEmo: A video database of natural facial expressions of emotions.

DynEmo is a database available to the scientific community (https://DynEmo.liglab.fr/). It contains dynamic and natural emotional facial expressions (EFEs) displaying subjective affective states rated by both the expresser and observers. Methodological and contextual information is provided for each expression. This multimodal corpus meets psychological, ethical, and technical criteria. It is quite large, containing two sets of 233 and 125 recordings of EFE of ordinary Caucasian people (ages 25 to 65, 182 females and 176 males) filmed in natural but standardized conditions. In the Set 1, EFE recordings are associated with the affective state of the expresser (self-reported after the emotion inducing task, using dimensional, action readiness, and emotional labels items). In the Set 2, EFE recordings are both associated with the affective state of the expresser and with the time line (continuous annotations) of observers' ratings of the emotions displayed throughout the recording. The time line allows any researcher interested in analysing non-verbal human behavior to segment the expressions into emotions.
Control of Single Axis Magnetic Levitation System Using Fuzzy Logic Control

This paper presents a fuzzy logic controller design for the stabilization of magnetic levitation system (Maglev 's). Additionally, the investigation on Linear Quadratic Regulator Controller (LQRC) also mentioned here. This paper presents the difference between the performance of fuzzy logic control (FLC) and LQRC for the same linear model of magnetic levitation system . A magnetic levitation is a nonlinear unstable system and the fuzzy logic controller brings the magnetic levitation system to a stable region by keeping a magnetic ball suspended in the air. The modeling of the system is simulated using Matlab Simulink and connected to Hilink platform and the maglev model of Zeltom company. This paper presents a comparison for both LQRC and FLC to control a ball suspended on the air. The performance results of simulation shows that the fuzzy logic controller had better performance than the LQR control.
Semi-Automatic Annotation of Music Collections

The amount of multimedia content in the World Wide Web is increasing very much, and music is one of the most outstanding. Every time, there are more and more songs, artists, and even new genres. Hence, it is really hard to manage this huge quantity, in terms of searching, filtering, navigating through the content, etc. One of the solutions for this problem is keeping annotations of the music files, in order to facilitate the retrieval process. However, it is known that annotating songs manually has a huge cost and annotating them automatically is quite inaccurate. The approach of this master thesis is to propose a semi-automatic strategy that allows to annotate huge music collections, based on audio similarity and a community of users that annotate music titles. This strategy allows to increase the efficiency regarding the manual annotation, and the accuracy regarding the automatic annotation. The Thesis presents two experiments followed for the evaluation of the annotation process: the first experiment consists on testing how the content–based similarity can propagate labels. Using a collection of of ∼5500 songs, we show that with a collection annotated at 40% with styles, we can reach a 78% (40%+38%) annotated collection, with a recall greater than or equal to 0.4, only using content–based similarity. In the case of moods, with a 30% annotated collection we can automatically propagate up to 65% (30%+35%). Regarding the second experiment, we use a collection of ∼258000 songs. With a 48% manually annotated collection we propagate the annotations up to 76% (48%+28%) and then evaluate a small set of the propagated annotations by means of user relevance feedback.