Miracle-dz/UniFAR-FTUs huggingface dataset:
Customer gender prediction based on E-commerce data

Demographic attributes of customers such as gender, age, etc. provide important information for e-commerce service providers in marketing and personalization of web applications. However, online customers often do not provide this kind of information due to privacy issues and other security-related reasons. In this paper, we proposed a method for predicting the gender of customers based on their catalog viewing data on e-commerce systems, such as the date and time of access, list of categories and products viewed, etc. We employ a machine learning approach and investigate a number of features derived from catalog viewing information to predict the gender of viewers. Experiments were conducted on datasets provided by the PAKDD'15 Data Mining Competition and achieved the good result. The results 81.2% on balanced accuracy and 81.4% on macro F1 score showed that basic features such as viewing time, products/categories features used together with more advanced features such as products/categories sequence and transfer features effectively facilitate gender prediction of customers.
Successful Management of Severe Unilateral Lower Extremity Lymphedema in an Outpatient Setting

Background and Purpose Non–cancer-related lymphedema is frequently unrecognized until it has advanced and, therefore, presents substantial management challenges. Treatment for lymphedema reflects cancer research and not the distinct complexities of non–cancer-related lymphedema. This case report describes an outpatient intervention for a patient with non–cancer-related unilateral lower extremity lymphedema. Case Description The patient was a 42-year-old woman who was morbidly obese and had left lower extremity chronic stage III lymphedema. Massive disfiguring lymphedema of her lower leg caused chronic wounds, pain, difficulty ambulating, and the inability to lift her leg in transfers. The patient received complete decongestive therapy (CDT) in an outpatient setting. Outcomes The volume of the patient's leg decreased more than 66%, so that her massive lower leg was transformed to nearly the same size as her unaffected limb. Proper compression management restored independent transfers and pain-free ambulation. Discussion Delayed diagnosis and treatment of non–cancer-related lymphedema result in increased severity and impaired mobility, making this a unique, complex condition requiring modifications to CDT in the outpatient setting. This case report demonstrates successful outpatient treatment of a patient with severe unilateral lower extremity lymphedema associated with large wounds and impaired mobility using CDT that was modified to accommodate her complex medical status, transportation barriers, and health insurance availability. Following 23 weeks of physical therapist interventions, the patient's affected lower extremity was the same size as the unaffected lower extremity, and she was independent in ambulation and stair climbing.
Ikaros: master of hematopoiesis, agent of leukemia

Ikaros is the founding member of a family of zinc finger transcription factors whose function during early hematopoietic development is required for differentiation into the three major hematopoietic lineages. Ikaros deletions have been described in human malignancies, particularly precursor B-cell leukemia. Deletions of this transcription factor appear to mediate leukemogenesis, although the exact mechanism is unclear. This article reviews the structure and function of Ikaros proteins in chromatin remodeling and gene expression as well as the current knowledge of Ikaros deletions in human malignancies. A new proteomic platform, mass cytometry, is introduced which allows measurements of greater than 30 parameters at the single-cell level and should thus provide a greater level of detail to unravel the mechanistic consequences of Ikaros dysfunction in leukemia.
Modeling the impacts of climate change and future land use variation on microbial transport

The impact of waterborne micro-organisms (potentially pathogenic) on public health may be exacerbated by the combined effects of climate and land use change. We used watershed modeling to assess the potential effects of climate change and future land management scenarios on microbial water quality in the Pigg River watershed, located in southwest Virginia, USA. The hydrologic simulation program in Fortran, climate forecasts from the Consortium for Atlantic Regional Assessment, future projections for land management, and current watershed data were used to simulate a range of potential future scenarios for the period 2040–2069. Results indicate that changes in climate will have the most significant impact on microbial fate and transport, with increased loading driven by trends in seasonal and annual precipitation. High flow and low flow periods represent periods of greatest uncertainty. As climate factors are to an extent uncontrollable, adaptation measures targeting land based source loads will be required to maintain water quality within existing regulatory standards. In addition, new initiatives may need to be identified and incorporated into water policy. This is likely to have repercussions for all watershed inhabitants and stakeholders, but will assist in sustaining water quality standards and protecting human health.
R7BP: A Surprising New Link Between G Proteins, RGS Proteins, and Nuclear Signaling in the Brain

The regulators of G protein signaling (RGS proteins) bind directly to G protein alpha (Gα) subunits in brain and other tissues to determine the strength, duration, and fidelity of neurotransmitter receptor signaling. A recent study shows, quite unexpectedly, that one class of RGS proteins [the R7 subfamily bound to Gβ5 (R7-Gβ5)] shuttles between the plasma membrane and the nucleus with assistance from a novel shuttle protein, R7BP. R7BP binds directly to R7-Gβ5 and the protein complex is tethered to the plasma membrane by addition of a lipid, palmitate, on R7BP. Removal of palmitate results in the translocation of the R7BP–R7-Gβ5 complex to the nucleus, presumably for nontraditional signaling functions. These findings suggest an entirely novel mechanism for regulating neurotransmitter signaling. That is, R7BP transduces signals directly from receptors and G proteins at the plasma membrane to the nucleus, and this plasma membrane–nuclear shuttling is controlled by reversible palmitoylation of R7BP.
Zebrafish pax8 is required for otic placode induction and plays a redundant role with Pax2 genes in the maintenance of the otic placode

Vertebrate Pax2 and Pax8 proteins are closely related transcription factors hypothesized to regulate early aspects of inner ear development. In zebrafish and mouse, Pax8 expression is the earliest known marker of otic induction, and Pax2 homologs are expressed at slightly later stages of placodal development. Analysis of compound mutants has not been reported. To facilitate analysis of zebrafish pax8, we completed sequencing of the entire gene, including the 5′ and 3′ UTRs. pax8 transcripts undergo complex alternative splicing to generate at least ten distinct isoforms. Two different subclasses of pax8 splice isoforms encode different translation initiation sites. Antisense morpholinos (MOs) were designed to block translation from both start sites, and four additional MOs were designed to target different exon-intron boundaries to block splicing. Injection of MOs, individually and in various combinations, generated similar phenotypes. Otic induction was impaired, and otic vesicles were small. Regional ear markers were expressed correctly, but hair cell production was significantly reduced. This phenotype was strongly enhanced by simultaneously disrupting either of the co-inducers fgf3 or fgf8, or another early regulator, dlx3b, which is thought to act in a parallel pathway. In contrast, the phenotype caused by disrupting foxi1, which is required for pax8 expression, was not enhanced by simultaneously disrupting pax8. Disrupting pax8, pax2a and pax2b did not further impair otic induction relative to loss of pax8 alone. However, the amount of otic tissue gradually decreased in pax8-pax2a-pax2b-deficient embryos such that no otic tissue was detectable by 24 hours post-fertilization. Loss of otic tissue did not correlate with increased cell death, suggesting that otic cells dedifferentiate or redifferentiate as other cell type(s). These data show that pax8 is initially required for normal otic induction, and subsequently pax8, pax2a and pax2b act redundantly to maintain otic fate.
Fee Comparisons of Treatments for Nonmelanoma Skin Cancer in a Private Practice Academic Setting

Objective To compare fees for biopsy, treatment procedure, repair, and 2‐month follow‐up for nonmelanoma skin cancer (NMSC) treatments: electrodesiccation and curettage (ED&C), excision, and Mohs micrographic surgery (MMS). METHODS: A cost comparison of 936 primary NMSCs diagnosed in 1999/2000 at a University affiliated dermatology practice. Clinical data was from medical record review. 2007 Medicare Fee Schedule costs determined fees for surgical care. Pearson chi‐square tests, t‐tests and analysis of variance compared fee differences. Linear regression determined independent effects of tumor and treatment characteristics on fees. Results Mean fees/lesion were $463 for ED&C, $1,222 for excision, and $2,085 for MMS (p < .001). For all treatments, primary procedure costs were highest (38%, 45%, and 41%). Total repair fees were higher with MMS ($735) vs excisions ($197). Fees were higher for head and neck tumors (p < .001), H‐zone tumors (p < .001), and tumors smaller than 10 mm in diameter (p = .04). Regression models predicted that the treatment fees would be $2,109 for MMS and $1,252 for excision (p < .001). Tumor size greater than 10 mm in diameter (added $128), tumors on the head and neck (added $966), and MMS (added $857 vs excision) were independently related to higher fees (p < .001). Conclusion Even after adjusting for risk factors, MMS has higher fees than excision for primary NMSC. Repairs accounted for the majority of this difference. These fee comparisons provide a basis for comparative effectiveness studies of treatments for this common cancer.
Do indoor pollutants and thermal conditions in schools influence student performance? A critical review of the literature.

UNLABELLED To assess whether school environments can adversely affect academic performance, we review scientific evidence relating indoor pollutants and thermal conditions, in schools or other indoor environments, to human performance or attendance. We critically review evidence for direct associations between these aspects of indoor environmental quality (IEQ) and performance or attendance. Secondarily, we summarize, without critique, evidence on indirect connections potentially linking IEQ to performance or attendance. Regarding direct associations, little strongly designed research was available. Persuasive evidence links higher indoor concentrations of NO(2) to reduced school attendance, and suggestive evidence links low ventilation rates to reduced performance. Regarding indirect associations, many studies link indoor dampness and microbiologic pollutants (primarily in homes) to asthma exacerbations and respiratory infections, which in turn have been related to reduced performance and attendance. Also, much evidence links poor IEQ (e.g. low ventilation rate, excess moisture, or formaldehyde) with adverse health effects in children and adults and documents dampness problems and inadequate ventilation as common in schools. Overall, evidence suggests that poor IEQ in schools is common and adversely influences the performance and attendance of students, primarily through health effects from indoor pollutants. Evidence is available to justify (i) immediate actions to assess and improve IEQ in schools and (ii) focused research to guide IEQ improvements in schools. PRACTICAL IMPLICATIONS There is more justification now for improving IEQ in schools to reduce health risks to students than to reduce performance or attendance risks. However, as IEQ-performance links are likely to operate largely through effects of IEQ on health, IEQ improvements that benefit the health of students are likely to have performance and attendance benefits as well. Immediate actions are warranted in schools to prevent dampness problems, inadequate ventilation, and excess indoor exposures to substances such as NO(2) and formaldehyde. Also, siting of new schools in areas with lower outdoor pollutant levels is preferable.
Exploring Possibilities of Preventing Sex Trafficking at the Source

Sex trafficking has been an issue of debate among academics and activists for long. While the official legal response of the state and one side of this debate remains rescue and rehabilitation with an aim to abolish or prevent exploitation for prostitution, the other side demands legalization or decriminalization with right to sex work. But the resultant action through all this remains more or less restricted to tackling the consequences of sex trafficking at the destination areas. This paper argues that the present day efforts at destination areas have been insufficient at tackling sex trafficking and hence there is a need to focus on the source areas and tackling the root causes of trafficking and preventing sex trafficking. This paper suggests two frameworks for this, namely, human rights framework and crime prevention approaches.
Effects of sleep deprivation on sleepiness, sleep intensity, and subsequent sleep in the rat.

The effects of 24 hr of sleep deprivation on cortical EEG and ventral hippocampus EEG recordings, ventral hippocampus spike rates, sleep stages percentages, and bout length measures were studied in rats. Two groups, differing only in the rate and distance they were forced to walk during deprivation by the water wheel method, were recorded continuously (23 hr per day) for one baseline, one deprivation, and two recovery days. During deprivation, microsleeps, increased hippocampal spike rates, and increased amplitude of the EEG recordings all suggested the intrusion of sleep processes. Nonetheless, there was no evidence to support the idea that these animals were not substantially deprived of sleep. No important differences were found in the recovery data of the two groups, even though one group walked three times as far as the other during deprivation. This supports the idea that, in conjunction with large amounts of sleep deprivation, changes in exercise and energy depletion may have little effect on sleep measures. During recovery, increased hippocampal spike rates and bout lengths, as well as increases in EEG amplitude, were interpreted in terms of increased sleep "intensity. " High amplitude NREM sleep rebounded first, followed by rebounds in both paradoxical sleep and low amplitude NREM sleep. This pattern was compared to patterns previously reported for humans, cats, and rats. Finally, the tendency for some measures to fall below their baseline levels after an initial rebound was discussed in terms of "sleep inhibition" and servomechanism theory.
Solid colloids with surface-mobile linkers

In this report we review the possibilities of using colloids with surface mobile linkers for the study of colloidal self-assembly processes. A promising route to create systems with mobile linkers is the use of lipid (bi-)layers. These lipid layers can be either used in the form of vesicles or as coatings for hard colloids and emulsion droplets. Inside the lipid bilayers molecules can be inserted via membrane anchors. Due to the fluidity of the lipid bilayer, the anchored molecules remain mobile. The use of different lipid mixtures even allows creating Janus-like particles that exhibit directional bonding if linkers are used which have a preference for a certain lipid phase. In nature mobile linkers can be found e.g. as receptors in cells. Therefore, towards the end of the review, we also briefly address the possibility of using colloids with surface mobile linkers as model systems to mimic cell–cell interactions and cell adhesion processes.
The customer behavior model of Internet securities dealing based on data mining

This paper discusses two patterns in data mining: association rules and sequential patterns, and describes the process to find these patterns by mining historical securities trading database. Through the analysis of mining result, this paper presents the concept and realization of customer behavior model, and successfully applies the model to advance the performance of Internet securities dealing system of CITIC Securities Co. Ltd. The customer behavior model presented by this paper is an important improvement of traditional securities trading.
A new RPWM technique with harmonics injection and frequency randomized modulation

This paper presents a new control strategy for the reduction of the electromagnetic vibration (and thus the acoustic noise emitted) in the external casing of a three-phase induction machine fed by a three-phase inverter. We compared the measurements of classical technique SPWM (Sinusoidal Pulse Width Modulation) and technical basis of this new strategy (without random parameters) with the new technique HIPWM-RWA (Pulse Width Modulation with Harmonics Injection and Randomized Working Angle) in an induction machine 1 KW idling.
Multilevel aggressive space mapping applied to coupled-resonator filters

An aggressive space mapping (ASM) method is presented for coupled-resonator filters specified by coupling matrices when two additional, geometry-based models are available: one precise but expensive and a lower-cost one. The method combines two levels of ASM between the three models, avoiding direct optimizations of the network response, and also costly computations of Jacobian matrices. The algorithm is illustrated with a microstrip coupled-line bandpass filter with cross-coupling and ten geometrical parameters, that is adjusted in only two iterations.
Hyperhomocysteinemia, oxidative stress, and cerebral vascular dysfunction.

An elevated circulating concentration of the sulfur-containing amino acid homocysteine, hyperhomocysteinemia, produces complex changes within the blood vessel wall. In the peripheral circulation, these changes include oxidative stress, proinflammatory effects such as expression of tumor necrosis factor-α and inducible nitric oxide (NO) synthase (iNOS), and endothelial dysfunction.1–6 Hyperhomocysteinemia-induced oxidative stress may occur as a result of decreased expression and/or activity of key antioxidant enzymes as well as increased enzymatic generation of superoxide anion (the precursor for multiple reactive oxygen and reactive nitrogen species). 2,4 Do hyperhomocysteinemia-induced changes occur in the cerebral circulation and why are they potentially important? Hyperhomocysteinemia is a an emerging risk factor for carotid artery disease (atherosclerosis) and stroke and is associated with Alzheimer’s disease and vascular dementia.7–11 It was not until relatively recently, however, that experimental studies began to define the impact of hyperhomocysteinemia on cerebral vascular biology and the molecular mechanisms that account for these changes. This work has been facilitated by the development of mouse models with genetic alterations in different components of the homocysteine metabolic pathway (see below). Early work in the cerebral microcirculation observed that acute local administration of a very high concentration of homocysteine (1 mmol/L) in the presence of exogenous Cu2+ produced superoxide-mediated reductions in resting cerebral blood flow (CBF) as well as attenuation of endothelium-dependent and NO-mediated responses.12 Our group was among the first to show that mild chronic hyperhomocysteinemia produces endothelial dysfunction in the carotid artery.1,13 Moderate hyperhomocysteinemia, induced by acute methionine loading, …
Digital Average Current-Mode Control Using Current Estimation and Capacitor Charge Balance Principle for DC–DC Converters Operating in DCM

A new digital average current-mode control technique is proposed for dc-dc converters operation in discontinuous conduction mode. In contrast to the regulation of inductor current, this paper focuses on how the suitable charge current is feed to capacitor and load resistor directly. Using the principle of capacitor charge balance, the charge current reference in next switching cycle is predicted in order to drive the output voltage back to its nominal value quickly during transient conditions. The actual average charge current is estimated from a simplified algorithm, which can also be used to calculate the required duty ratio according to the charge current reference. This control technique features good dynamic performance and it is compliant with the performance constraints of digital integrated processor. The effectiveness of the proposed solution has been proved by the simulation and experimental results.
Epidemiology of bluetongue in Central America and the Caribbean: initial entomological findings

Abstract. Forty‐four species of Culicoides (Diptera: Ceratopogonidae) were caught in insect light traps during the first 2 years of studies on the epidemiology of bluetongue virus in the Caribbean and Central America. Traps were operated near sentinel ruminants which were bled monthly for serologic evaluation and then virus isolation. More than 570,000 individuals were identified. Culicoides insignis Lutz accounted for 90% of the catch, C.filarifer Hoffman/C.ocumarensis Ortiz 5%, C.furens Poey 3% and C.pusillus Lutz 2%. Other species accounted for less than 1% of the total catch. Sentinel ruminants became seropositive when C.insignis populations were high at many study sites. At a few sites C.pusillus and C.filarifer I C.ocumarensis were predominant or were present in large numbers during seroconversions of sentinels. Virus isolations were obtained from sentinel ruminants during times when these same species were present in large populations.
Fundamentals of Operative Dentistry: A Contemporary Approach

This text blends traditional, proven methods and recent scientific developments, such as adhesive technologies and resin composites. With a commitment to conservative procedures, the authors describe scientific bases and techniques for the range of restorative options now available. While intended primarily for students, the text will also be valuable to the practitioner seeking an update on the subject.
Differences in catecholamine metabolism and behaviour in neonatal broiler and layer chicks

1. To clarify the difference in behavioural activities and catecholamine metabolism between layer and broiler-type chicks two experiments were conducted. 2. In experiment 1, 1-d-old male layer and broiler chicks were placed in an open-field area and their responses were investigated for 10 min. The responses of the two strains were remarkably different, with broilers being less active than layers. Vocalisations rapidly decreased in broilers whereas those of layers remained elevated during the 10 min. 3. In experiment 2, 1-d-old chicks of both strains were killed and brain catecholamine concentrations were determined in three parts of the brain: telencephalon, optic lobe and brain stem. 4. In the whole brain, dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) were significantly higher in broilers. However, the values for norepinephrine (NE), epinephrine (E) and 4-hydroxy-3-methoxyphenylacetic acid (HVA) were similar between strains. The ratios of metabolite/precursor were also calculated: HVA/DOPAC was higher in layers, while NE/DA, E/NE and DOPAC/DA were not significantly different between strains. 5. These results suggest that behavioural activities differ greatly, while there are some differences in catecholamine metabolism between the two strains.