Miracle-dz/UniFAR-FTUs huggingface dataset:
The targeted anti‐oxidant MitoQ causes mitochondrial swelling and depolarization in kidney tissue

Kidney proximal tubules (PTs) contain a high density of mitochondria, which are required to generate ATP to power solute transport. Mitochondrial dysfunction is implicated in the pathogenesis of numerous kidney diseases. Damaged mitochondria are thought to produce excess reactive oxygen species (ROS), which can lead to oxidative stress and activation of cell death pathways. MitoQ is a mitochondrial targeted anti‐oxidant that has shown promise in preclinical models of renal diseases. However, recent studies in nonkidney cells have suggested that MitoQ might also have adverse effects. Here, using a live imaging approach, and both in vitro and ex vivo models, we show that MitoQ induces rapid swelling and depolarization of mitochondria in PT cells, but these effects were not observed with SS‐31, another targeted anti‐oxidant. MitoQ consists of a lipophilic cation (Tetraphenylphosphonium [TPP]) joined to an anti‐oxidant component (quinone) by a 10‐carbon alkyl chain, which is thought to insert into the inner mitochondrial membrane (IMM). We found that mitochondrial swelling and depolarization was also induced by dodecyltriphenylphosphomium (DTPP), which consists of TPP and the alkyl chain, but not by TPP alone. Surprisingly, MitoQ‐induced mitochondrial swelling occurred in the absence of a decrease in oxygen consumption rate. We also found that DTPP directly increased the permeability of artificial liposomes with a cardiolipin content similar to that of the IMM. In summary, MitoQ causes mitochondrial swelling and depolarization in PT cells by a mechanism unrelated to anti‐oxidant activity, most likely because of increased IMM permeability due to insertion of the alkyl chain.
16 Riemann ’ s zeta function and the prime number theorem

We now divert our attention from algebraic number theory to talk about zeta functions and L-functions. As we shall see, every global field has a zeta function that is intimately related to the distribution of its primes. We begin with the zeta function of the rational field Q, which we will use to prove the prime number theorem. We will need some basic results from complex analysis, all of which can be found in any introductory textbook (such as [1, 2, 3, 7, 12]). A short glossary of terms and a list of the basic theorems we will use can be found at the end of these notes.1
Virtual-Mobile-Core Placement for Metro Network

Traditional highly-centralized mobile core networks (e.g., Evolved Packet Core (EPC)) need to be constantly upgraded both in their network functions and backhaul links, to meet increasing traffic demands. Network Function Virtualization (NFV) is being investigated as a potential cost-effective solution for this upgrade. A virtual mobile core (here, virtual EPC, vEPC) provides deployment flexibility and scalability while reducing costs, network-resource consumption and application delay. Moreover, a distributed deployment of vEPC is essential for emerging paradigms like Multi-Access Edge Computing (MEC). In this work, we show that significant reduction in network-resource consumption can be achieved as a result of optimal placement of vEPC functions in metro area. Further, we show that not all vEPC functions need to be distributed. In our study, for the first time, we account for vEPC interactions in both data and control planes (Non-Access Stratum (NAS) signaling procedure Service Chains (SCs) with application latency requirements) using a detailed mathematical model.
Case Report: Dermoscopic features of oral lichen planus - the evolution of mucoscopy

Dermoscopy, a non-invasive technique for cutaneous diagnosis is being increasingly studied in various disorders of the skin, nails and scalp. However, it has been under-utilized for the diagnosis and characterization of mucosal disorders. The dermoscopic characterization of cutaneous lichen planus and its variants has been well documented with Wickham’s striae constituting the hallmark of the condition. However, the dermoscopic features of oral lichen planus with hand-held or videodermoscopy remain to be elucidated. We present the case of a young adult man who presented with asymptomatic white lacy lesions over a bluish-black background over the tongue, patchy hyperpigmentation of the buccal mucosae and gingivae, and longitudinal melanonychia involving some nails. History of intake of any drugs preceding the lesions, smoking, chewing of betel nut and dental implants was negative. Family history was non-contributory. There were no cutaneous lesions suggestive of lichen planus. Mucoscopy (dermoscopy of the mucosa, oral in this case) and onychoscopy were done followed by biopsy from the tongue that confirmed the diagnosis of lichen planus. Oral mucoscopy of the tongue revealed a tri-colored pattern with structureless veil-like grey-white areas (modified Wickham’s striae), well-demarcated red glossy erosions, and violaceous-to-brown clods. Additionally, vascular pattern of dotted and linear to curved vessels along the borders of leukoplakia-like areas and erosions were observed. Onychoscopy confirmed lichen planus-associated melanonychia. Dermoscopy also proved useful in conveniently ruling out other disorders typified by mucosal and nail pigmentation such as Laugier Hunziker syndrome and drug-induced changes. Although direct oral microscopy has been used in defining features of oral lichen planus, to the best of our knowledge this case is the first report on mucoscopy or dermoscopy of oral lichen planus
Linearly Polarized and Circularly Polarized Wideband Dipole Antennas With Reconfigurable Beam Direction

Linearly polarized (LP) and circularly polarized (CP) dipole antennas with switchable beams are presented. The beam-switchable reconfigurability is realized by electronically controlling the state of switches on the side apertures of a square substrate integrated waveguide (SIW). Four wide dipoles are loaded in front of the four apertures. To generate one desired unidirectional radiation beam, the corresponding aperture is switched ON, which excites the corresponding dipole. Meanwhile, the other three apertures are switched off and perform as electric walls in the SIW. In this way, the other three dipoles work as reflectors of the excited dipole. Wide bandwidths and good directional radiation patterns can be obtained. Two fully functional LP and CP antenna prototypes with more than 47% bandwidths are developed and tested. The measurement result demonstrates antennas with measured gains of approximately 4.5 dBi and radiation efficiencies of approximately 80% over the operating band. Owing to the symmetrical antenna structures, the two designs are capable of switching the radiation beam at every 90° in the azimuth plane with identical patterns. In addition, the proposed designs possess compact antenna sizes, i.e., <inline-formula> <tex-math notation="LaTeX">$0.51\lambda _{0}\times 0.51\lambda _{0}\times 0.39\lambda _{0}$ </tex-math></inline-formula> for the LP antenna and <inline-formula> <tex-math notation="LaTeX">$0.95\lambda _{0}\times 0.95\lambda _{0}\times 0.46\lambda _{0}$ </tex-math></inline-formula> for the CP antenna, where <inline-formula> <tex-math notation="LaTeX">$\lambda _{0}$ </tex-math></inline-formula> represents the free-space wavelength at the center frequency of 2.2 GHz.
Targeted Metabolomic and Transcriptomic Analyses of “Red Russian” Kale (Brassicae napus var. pabularia) Following Methyl Jasmonate Treatment and Larval Infestation by the Cabbage Looper (Trichoplusia ni Hübner)

Methyl jasmonate (MeJA), synthesized in the jasmonic acid (JA) pathway, has been found to upregulate glucosinolate (GS) biosynthesis in plant species of the Brassicaceae family. Exogenous application of MeJA has shown to increase tissue GS concentrations and the formation of myrosinase-mediated GS hydrolysis products (GSHPs). In vitro and in vivo assays have demonstrated the potential health-promoting effects of certain GSHPs. MeJA is also known to elicit and induce genes associated with defense mechanisms to insect herbivory in Brassica species. To investigate the relationship between MeJA-induced GS biosynthesis and insect defense, three treatments were applied to “Red Russian” kale (Brassicae napus var. pabularia) seedlings: (1) a 250 µM MeJA leaf spray treatment; (2) leaf infestation with larvae of the cabbage looper (Trichoplusia ni (Hübner)); (3) control treatment (neither larval infestation nor MeJA application). Samples of leaf tissue from the three treatments were then assayed for changes in GS and GSHP concentrations, GS gene biosynthesis expression, and myrosinase activity. Major differences were observed between the three treatments in the levels of GS accumulation and GS gene expression. The insect-damaged samples showed significantly lower aliphatic GS accumulation, while both MeJA and T. ni infestation treatments induced greater accumulation of indolyl GS. The gene expression levels of CYP81F4, MYB34, and MYB122 were significantly upregulated in samples treated with MeJA and insects compared to the control group, which explained the increased indolyl GS concentration. The results suggest that the metabolic changes promoted by MeJA application and the insect herbivory response share common mechanisms of induction. This work provides potentially useful information for kale pest control and nutritional quality.
Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance

This AASLD 2018 Hepatitis B Guidance is intended to complement the AASLD 2016 Practice Guidelines for Treatment of Chronic Hepatitis B and update the previous hepatitis B virus (HBV) guidelines from 2009. The 2018 updated guidance on chronic hepatitis B (CHB) includes (1) updates on treatment since the 2016 HBV guidelines (notably the use of tenofovir alafenamide) and guidance on (2) screening, counseling, and prevention; (3) specialized virological and serological tests; (4) monitoring of untreated patients; and (5) treatment of hepatitis B in special populations, including persons with viral coinfections, acute hepatitis B, recipients of immunosuppressive therapy, and transplant recipients. The AASLD 2018 Hepatitis B Guidance provides a data-supported approach to screening, prevention, diagnosis, and clinical management of patients with hepatitis B. It differs from the published 2016 AASLD guidelines, which conducted systematic reviews and used a multidisciplinary panel of experts to rate the quality (level) of the evidence and the strength of each recommendation using the Grading of Recommendations Assessment, Development and Evaluation system in support of guideline recommendations. In contrast, this guidance document was developed by consensus of an expert panel, without formal systematic review or use of the Grading of Recommendations Assessment, Development, and Evaluation system. The 2018 guidance is based upon the following: (1) formal review and analysis of published literature on the topics; (2) World Health Organization guidance on prevention, care, and treatment of CHB; and (3) the authors’ experience in acute hepatitis B andCHB. Intended for use by health care providers, this guidance identifies preferred approaches to the diagnostic, therapeutic, and preventive aspects of care for patients with CHB. As with clinical practice guidelines, it provides general guidance to optimize the care of the
Type B adverse drug reactions reported by an immunoallergology department

Objective: Characterization of the adverse drug reactions (ADR) reported by the immunoallergology department (IAD), Centro Hospitalar de São João (Porto), to the Northern Pharmacovigilance Centre (NPC). Methods: An observational, descriptive and retrospective study was conducted, based in a spontaneous report system. Participants were all the patients from the IAD, with suspected ADR, reported to NPC by specialists after the study was completed. Results: Studied population had a median age of 41 years, with the predominance of the female gender (73.2%). Allergic rhinitis and asthma were the most frequent comorbidities. All studied ADR were type B, 89.6% were serious, 86.4% unexpected and 2.6% associated with drugs that presented less than 2 years in the market. The most represented drug classes were the non-steroidal anti-inflammatory drugs (NSAIDs) (52.6%) and antibiotics (25.2%). Skin symptoms represented 61.2% of the reported complaints. About 52.9% of these ADR occurred in less than one hour after intake. The most frequent ADR treatment at the time of the reaction was drug interruption (86.2%), followed by the prescription of anti-histamines (42.2%). Conclusions: Reported ADR to NPC by the Drug Alert Unit were mainly serious, unexpected, associated with NSAIDs and antibiotics and related with marketing authorization medicines older than two years. These results could be very useful to develop strategies to prevent the clinical and economic consequences of ADR.
LATE ONSET RHEUMATOID ARTHRITIS: AN OBSERVATIONAL STUDY

Rheumatoid arthritis (RA) may have an onset at older age. Th e onset of the disease at the age of 60 and over is called late-onset rheumatoid arthritis (LORA). Th e aim of this study was to analyze the clinical, laboratory, radiological, and treatment characteristics of patients with LORA compared to those with early-onset RA (EaORA), provided that all the patients had an approximately equal duration of the disease. Th is is an observational single-center study, which involved 120 patients with an established diagnosis of RA, of which 60 patients had LORA, and 60 patients EaORA. Th e disease activity, measured by the Disease Activity Score 28 (DAS28-ESR), was signifi cantly higher in the LORA group compared to the EaORA group (p<0.05). Signifi cantly more patients with LORA had involvement of the shoulders (LORA vs. EaORA, 30% vs. 15%; p <0.05) and knees (LORA vs. EaORA, 46.7% vs. 16.7%; p <0.05). Radiological erosive changes were signifi cantly more frequent in the LORA group in comparison with EaORA (p <0.05). Th ere was no diff erence between the groups regarding rheumatoid factor (RF) positivity (p>0.05), while the number of patients positive for anti-citrullinated protein antibody (ACPA) was signifi cantly greater in the EaORA group (p<0.05). Th e values of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were signifi cantly higher in the LORA than in the EaORA group. Hemoglobin levels were lower in the LORA group (11.96±1.64 g/dL) than in the EaORA group (12.18±1.56 g/dL). Th e most used disease-modifying antirheumatic drugs (DMARDs) were methotrexate and sulfasalazine, while biological drugs were not used. In conclusion, based on the results of our study, LORA has some features that distinguish it from EaORA, such as higher disease activity, more frequent involvement of large joints, and more pronounced structural damage. Th is should be taken in account in clinical practice, especially regarding treatment choices. Ključne riječi: Reumatoidni artritis – epidemiologija, patofi ziologija, radiografi ja, farmakoterapija; Reumatoid ni faktor – u krvi; Autoantitijela – u krvi; Ciklički peptidi – imunologija; C-reaktivni protein – analiza; Zglobovi – patologija; Antireumatici – terapijska primjena; Dobna granica pojavnosti; Indeks težine bolesti Sažetak. Reumatoidni artritis (RA) može imati početak u starijoj životnoj dobi. Nastup bolesti sa 60 i više godina naziva se RA kasnog početka (engl. Late-Onset Rheumatoid Arthritis – LORA). Cilj ove studije bio je analiziraProfessional paper
Polysomnography Applied to Patients with Tinnitus: A Review

Abstract Introduction Tinnitus has been defined as an “auditory phantom perception,” meaning that tinnitus results from an abnormal activity within the nervous system, in the absence of any internal or external acoustic stimulation. About 10 to 15% of the adult population is affected by tinnitus, and a relevant percentage of tinnitus sufferers experience symptoms severe enough to significantly affect quality of life, including sleep disturbances, work impairment, and, in some cases, psychiatric distress. The self-rated complaints about tinnitus focus on emotional distress, auditory perceptual difficulties, and sleep disturbances. Objectives To evaluate the works that show sleep disorders in patients with tinnitus, and sleep disorders assessed by polysomnography. Data Synthesis We found four studies with polysomnography to assess sleep disorders in patients with tinnitus. The first study evaluated 80 patients who were military personnel without major psychiatric disturbances, and their tinnitus was associated with noise-induced permanent hearing. The second study was a prospective, case-control, nonrandomized study of 18 patients affected by chronic tinnitus who were compared with a homogeneous control group consisting of 15 healthy subjects. The last work evaluated questionnaires mailed to patients before their initial appointment at the Oregon Health Sciences University Tinnitus Clinic between 1994 and 1997. These questionnaires requested information pertaining to insomnia, tinnitus severity, and loudness. Follow-up questionnaires were mailed to 350 patients 1 to 4 years (mean 5 ± 2.3 years) after their initial appointment at the clinic. Conclusion There are few studies with polysomnography for the evaluation of patients with sleep disorders caused by tinnitus. This shows the need for more studies on this subject.
INVESTIGATION OF THE MECHANICAL PROPERTIES OF NANOCOMPOSITE SWCNTS/EPOXY BY MICROMECHANICS METHODS AND EXPERIMENTAL WORKS

In the present paper, the stiffening effect of carbon nanotubes is quantitatively investigated by micromechanics methods. The Mori-Tanaka effective-field method is employed to calculate the effective elastic moduli of composites with aligned or randomly oriented straight nanotubes. In addition, the epoxy resin is modified experimentally by adding SWCNT with different ratio i.e 0, 0.1, 0.3, 0.5 and 0.7 wt. -% . A comparison between the results for SWCNT/epoxy nanocomposite which obtained analytically and experimentally is done. In the experimental work the epoxy resin is modified by adding SWCNT with different ratio i.e 0, 0.1, 0.3, 0.5 and 0.7 wt. -% . The materials are characterized in tension to obtain the mechanical properties of SWCNT/epoxy nanocomposite experimentally. The results of micromechanics methods indicated that the CNTs are highly anisotropic, with Young’s modulus in the tube direction two orders of magnitude higher than that normal to the tube. The results shows a nanotube volume fraction of 0.3%of SWCNT improve all mechanical properties such as the tensile strength, modulus of elasticity and the toughness. Avoid the volume fraction greater than 0.5% SWCNT. The optimal value achieved experimentally, (at 0.3% SWCNT) lies between the analytical values (that achieved parallel to the CNT and the randomly orientated straight CNTs ) .
Not a one-trick pony: Diverse connectivity and functions of the rodent lateral geniculate complex

Abstract Often mislabeled as a simple relay of sensory information, the thalamus is a complicated structure with diverse functions. This diversity is exemplified by roles visual thalamus plays in processing and transmitting light-derived stimuli. Such light-derived signals are transmitted to the thalamus by retinal ganglion cells (RGCs), the sole projection neurons of the retina. Axons from RGCs innervate more than ten distinct nuclei within thalamus, including those of the lateral geniculate complex. Nuclei within the lateral geniculate complex of nocturnal rodents, which include the dorsal lateral geniculate nucleus (dLGN), ventral lateral geniculate nucleus (vLGN), and intergeniculate leaflet (IGL), are each densely innervated by retinal projections, yet, exhibit distinct cytoarchitecture and connectivity. These features suggest that each nucleus within this complex plays a unique role in processing and transmitting light-derived signals. Here, we review the diverse cytoarchitecture and connectivity of these nuclei in nocturnal rodents, in an effort to highlight roles for dLGN in vision and for vLGN and IGL in visuomotor, vestibular, ocular, and circadian function.
Mitochondrial dysfunction in an animal model of diabetic neuropathy is associated with a reduction of neurosteroid synthesis.

Background : Recent work in a model of diabetic neuropathy revealed that layer 2/3 cortical pyramidal neurones of the pain pathway exhibited reduced endogenous neurosteroid modulation of the GABA AR and exogenously applied neurosteroids had an exaggerated impact. It is postulated that this is related to reduced precursor synthesis, due to mitochondrial dysfunction in diabetic neuropathy. Benzodiazepines are also known to activate neurosteroidogenesis by binding to mitochondrial translocator protein (TSPO). This study explored the differential effect of diazepam on GABA AR modulation via neurosteroidogenesis in diabetic and wild type (WT) mice. Methods : Whole-cell patch-clamp technique was used on slices of neural tissue. Electrophysiological recordings were obtained from layer 2/3 cortical pyramidal neurons of the pain pathway from mice with type-II diabetic neuropathy ( ob/ob) and WT controls aged 60-80 days. Results : There was a key difference in the response of the WT and ob/ob cortical neurons to simultaneous incubation with diazepam and flumazenil. In contrast, diazepam and the 5a-reductase inhibitor finasteride, individually or in combination, produced the same response in both strains. Conclusions : The exaggerated effect of diazepam on GABAergic inhibitory tone in the ob/ob, despite the presence of the GABA AR benzodiazepine antagonist flumazenil is likely observed due to physiological upregulation of key neurosteroidogenic enzymes in response to the reduced pregnenolone synthesis by the mitochondria. By increasing pregnenolone via TSPO activation, it is possible to promote enhanced neurosteroidogenesis and increase GABAergic inhibitory tone via an alternate route. In diabetic neuropathy, mitochondrial dysfunction may play an important role. Enhancing the GABAergic neurosteroid tone could be of potential therapeutic benefit.
Metallic nano/microglasses: new approaches in nanostructured materials science

This paper reviews the state of the art in metallic nano/microglasses, with a focus on their preparation methods, structure, and physical/mechanical properties. Characterization methods for these glasses are reviewed together with how size effects, temperature variation, and ion irradiation contribute to the increase in their ductility. Some aspects that require more detailed study are identified.
Fuzzy Sparse Autoencoder Framework for Single Image Per Person Face Recognition

The issue of single sample per person (SSPP) face recognition has attracted more and more attention in recent years. Patch/local-based algorithm is one of the most popular categories to address the issue, as patch/local features are robust to face image variations. However, the global discriminative information is ignored in patch/local-based algorithm, which is crucial to recognize the nondiscriminative region of face images. To make the best of the advantage of both local information and global information, a novel two-layer local-to-global feature learning framework is proposed to address SSPP face recognition. In the first layer, the objective-oriented local features are learned by a patch-based fuzzy rough set feature selection strategy. The obtained local features are not only robust to the image variations, but also usable to preserve the discrimination ability of original patches. Global structural information is extracted from local features by a sparse autoencoder in the second layer, which reduces the negative effect of nondiscriminative regions. Besides, the proposed framework is a shallow network, which avoids the over-fitting caused by using multilayer network to address SSPP problem. The experimental results have shown that the proposed local-to-global feature learning framework can achieve superior performance than other state-of-the-art feature learning algorithms for SSPP face recognition.