Miracle-dz/UniFAR-FTUs huggingface dataset:
Unsupervised maritime traffic pattern extraction from spatio-temporal data

Maritime traffic pattern extraction is a fundamental and crucial factor for maritime surveillance and anomaly detection. Emerging technologies like Automatic Identification System (AIS) provides multi-dimensional data which is used to construct a maritime traffic model. In this paper, we propose a framework of maritime traffic pattern extraction from vessel AIS information, which learns a traffic pattern using an unsupervised technique, and can be applied on historical Automatic Identification System data. AIS data is a kind of spatio-temporal data that contains information of location data, as well as time stamps. In this way, traffic pattern is described by AIS data. Furthermore, we conduct a simulation experiment that extracts traffic pattern from the AIS data through the unsupervised technique. The proposed framework takes advantage of AIS data, which is a type of the spatiotemporal data that consists of vessel motion information, to perform the experiment. The result shows that the unsupervised framework converts useful information from raw AIS data to effective traffic pattern. The proposed method strongly supports the further research on maritime traffic pattern extraction of AIS data. Besides, an overview of the framework and the unsupervised technique for high-level maritime situation awareness is presented.
Synchronization in Vehicle Routing - A Survey of VRPs with Multiple Synchronization Constraints

This paper presents a survey of vehicle routing problems with multiple synchronization constraints. These problems exhibit, in addition to the usual task covering constraints, further synchronization requirements between the vehicles, concerning spatial, temporal, and load aspects. They constitute an emerging field in vehicle routing research and are becoming a “hot” topic. The contribution of the paper is threefold: (i) It presents a classification of different types of synchronization. (ii) It discusses the central issues related to the exact and heuristic solution of such problems. (iii) It comprehensively reviews pertinent literature with respect to applications as well as successful solution approaches, and it identifies promising algorithmic avenues.
Infant feeding patterns and risks of death and hospitalization in the first half of infancy: multicentre cohort study.

OBJECTIVE To determine the association of different feeding patterns for infants (exclusive breastfeeding, predominant breastfeeding, partial breastfeeding and no breastfeeding) with mortality and hospital admissions during the first half of infancy. METHODS This paper is based on a secondary analysis of data from a multicentre randomized controlled trial on immunization-linked vitamin A supplementation. Altogether, 9424 infants and their mothers (2919 in Ghana, 4000 in India and 2505 in Peru) were enrolled when infants were 18-42 days old in two urban slums in New Delhi, India, a periurban shanty town in Lima, Peru, and 37 villages in the Kintampo district of Ghana. Mother-infant pairs were visited at home every 4 weeks from the time the infant received the first dose of oral polio vaccine and diphtheria-pertussis-tetanus at the age of 6 weeks in Ghana and India and at the age of 10 weeks in Peru. At each visit, mothers were queried about what they had offered their infant to eat or drink during the past week. Information was also collected on hospital admissions and deaths occurring between the ages of 6 weeks and 6 months. The main outcome measures were all-cause mortality, diarrhoea-specific mortality, mortality caused by acute lower respiratory infections, and hospital admissions. FINDINGS There was no significant difference in the risk of death between children who were exclusively breastfed and those who were predominantly breastfed (adjusted hazard ratio (HR) = 1.46; 95% confidence interval (CI) = 0.75-2.86). Non-breastfed infants had a higher risk of dying when compared with those who had been predominantly breastfed (HR = 10.5; 95% CI = 5.0-22.0; P < 0.001) as did partially breastfed infants (HR = 2.46; 95% CI = 1.44-4.18; P = 0.001). CONCLUSION There are two major implications of these findings. First, the extremely high risks of infant mortality associated with not being breastfed need to be taken into account when informing HIV-infected mothers about options for feeding their infants. Second, our finding that the risks of death are similar for infants who are predominantly breastfed and those who are exclusively breastfed suggests that in settings where rates of predominant breastfeeding are already high, promotion efforts should focus on sustaining these high rates rather than on attempting to achieve a shift from predominant breastfeeding to exclusive breastfeeding.
Posterior Lumbar Interbody Fusion via a Unilateral Approach

This study sought to determine the outcomes of posterior lumbar interbody fusion (PLIF), via a unilateral approach, in selected patients who presented with unilateral leg pain and segmental instability of the lumbar spine. Patients with a single level of a herniated disc disease in the lumbar spine, unilateral leg pain, chronic disabling lower back pain (LBP), and a failed conservative treatment, were considered for the procedure. A total of 41 patients underwent a single-level PLIF using two PEEK™ (Poly-Ether-Ether-Ketone) cages filled with iliac bone, via a unilateral approach. The patients comprised 21 women and 20 men with a mean age of 41 years (range: 22 to 63 years). Two cages were inserted using a unilateral medial facetectomy and a partial hemilaminectomy. At follow-up, the outcomes were assessed using the Prolo Scale. The success of the fusion was determined by dynamic lumbar radiography and/or computerized tomography scanning. All the patients safely underwent surgery without severe complications. During a mean follow-up period of 26 months, 1 patient underwent percutaneous pedicle screw fixation due to persistent LBP. A posterior displacement of the cage was found in one patient. At the last follow up, 90% of the patients demonstrated satisfactory results. An osseous fusion was present in 85% of the patients. A PLIF, via a unilateral approach, enables a solid union with satisfactory clinical results. This preserves part of the posterior elements of the lumbar spine in selected patients with single level instability and unilateral leg pain.
Improved glucose control associated with i.v. chromium administration in two patients receiving enteral nutrition.

PURPOSE The effect of i.v. chromium administration on glucose control in two patients receiving enteral nutrition is described. SUMMARY Chromium supplementation has been hypothesized to potentiate the actions of insulin in facilitating cellular uptake of glucose. We report two cases-one involving a diabetic patient and the other a nondiabetic patient-in which chromium administration appeared to decrease insulin requirements. In case 1, a diabetic patient given a single course of chromic chloride appeared to have a probable response to the drug. Within the first day of chromic chloride administration, insulin requirements declined. When chromic chloride was discontinued, insulin requirements did not rise, suggesting efficacy and sustained effect. The patient's glucose intake and blood glucose levels remained relatively stable, while there was a significant decline in insulin requirements. Serum chromium levels were not assessed, so it is uncertain if the patient experienced chromium deficiency or if it was adequately treated with chromium supplementation, and a dose-response relationship could not be ascertained because the patient received a continuous infusion of chromium. In case 2, the insulin requirements of a nondiabetic patient appeared to decrease in response to multiple courses of chromic chloride. Upon initial discontinuation of chromic chloride, the patient's lower insulin requirements were sustained for a few days, but changes in clinical status and other medications precipitated elevated insulin requirements and the need for subsequent chromic chloride administration. Further research in more controlled settings is necessary to elucidate chromium's effect on insulin requirements. CONCLUSION Infusion of chromic chloride appeared to reduce insulin requirements in one diabetic patient and one nondiabetic patient.
Human action recognition from silhouettes using manifold learning and MDA

In this paper, a method for human action recognition based on silhouette observations is presented. The methodology combines neighbourhood preserving embedding (NPE) based dimensionality reduction and multiple discriminant analysis (MDA) based action discrimination. Since depth is more robust to appearance variations and enables the spatial relationship to be explored easily for future multi-target interaction, a miniature stereo vision machine with three cameras is employed for generating high-resolution dense depth maps at video rate. The silhouettes of a moving person are extracted as the input features through fusing colour and depth information. Motivated by the observation that human activities are often located on a low-dimensional latent space, NPE is adopted to learn the intrinsic action manifold. When the class information is available, MDA is utilised to find a linear subspace which is optimal for discrimination. Experimental results show that our system can recognise human actions accurately with temporal, intra- and inter-person variations.
Estrogen and progesterone receptor testing in breast carcinoma: concordance of results between local and reference laboratories in Brazil

ABSTRACT CONTEXT AND OBJECTIVE: Breast cancer accounts for approximately one quarter of all cancers in females. Estrogen and progesterone receptor testing has become an essential part of the clinical evaluation of breast carcinoma patients, and accurate results are critical in identifying patients who may benefit from hormone therapy. The present study had the aim of investigating the concordance of the results from hormone receptor tests between a reference laboratory and local (or community) laboratories in Brazil. DESIGN AND SETTING: Retrospective study at a reference pathology laboratory. METHODS: The concordance in the results from hormone receptor tests between a reference laboratory and 146 local laboratories in Brazil was compared in relation to 500 invasive breast carcinoma cases, using immunohistochemistry. RESULTS: There was concordance in 89.4% (447/500 cases) and 85.0% (425/500 cases) of the results from estrogen (k = 0.744, P < 0.001) and progesterone (k = 0.688, P < 0.001) receptor tests, respectively, between local and reference laboratories. This was similar to findings in other countries. The false negative rates from estrogen and progesterone receptor tests in local laboratories were 8.7% and 14.4%, respectively. The false positive rates from estrogen and progesterone receptor tests in local laboratories were 15.5% and 16.0%, respectively. CONCLUSION: Technical and result interpretation issues may explain most of the discordances in hormone receptor testing in local laboratories. Validation of estrogen and progesterone receptor tests at local laboratories, with rigorous quality control measures, is strongly recommended in order to avoid erroneous treatment of breast cancer patients.
Assessing hippocampal development and language in early childhood: Evidence from a new application of the Automatic Segmentation Adapter Tool

Volumetric assessments of the hippocampus and other brain structures during childhood provide useful indices of brain development and correlates of cognitive functioning in typically and atypically developing children. Automated methods such as FreeSurfer promise efficient and replicable segmentation, but may include errors which are avoided by trained manual tracers. A recently devised automated correction tool that uses a machine learning algorithm to remove systematic errors, the Automatic Segmentation Adapter Tool (ASAT), was capable of substantially improving the accuracy of FreeSurfer segmentations in an adult sample [Wang et al., 2011], but the utility of ASAT has not been examined in pediatric samples. In Study 1, the validity of FreeSurfer and ASAT corrected hippocampal segmentations were examined in 20 typically developing children and 20 children with autism spectrum disorder aged 2 and 3 years. We showed that while neither FreeSurfer nor ASAT accuracy differed by disorder or age, the accuracy of ASAT corrected segmentations were substantially better than FreeSurfer segmentations in every case, using as few as 10 training examples. In Study 2, we applied ASAT to 89 typically developing children aged 2 to 4 years to examine relations between hippocampal volume, age, sex, and expressive language. Girls had smaller hippocampi overall, and in left hippocampus this difference was larger in older than younger girls. Expressive language ability was greater in older children, and this difference was larger in those with larger hippocampi, bilaterally. Overall, this research shows that ASAT is highly reliable and useful to examinations relating behavior to hippocampal structure. Hum Brain Mapp 36:4483–4496, 2015. © 2015 Wiley Periodicals, Inc.
Antibacterial Activity of Extracts of Acacia Aroma Against Methicillin-Resistant And Methicillin-Sensitive Staphylococcus

Antibacterial activity of organic and aqueous extracts of Acacia aroma was evaluated against methicillin-resistant Staphylococcus aureus (MRSA), methicillin sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus epidermidis. Inhibition of bacterial growth was determined using agar diffusion and bioautographic methods. Among all assayed organic extracts only ethanolic and ethyl acetate extracts presented highest activities against all tested Staphylococcus strains with minimal inhibitory concentration (MIC) values ranging from 2.5 to 10 mg/ml and from 2.5 to 5 mg/ml respectively. The aqueous extracts show little antibacterial activity against Staphylococcus strains. The bioautography assay demonstrated well-defined growth inhibition zones against S. aureus in correspondence with flavonoids and saponins. A. aroma would be an interesting topic for further study and possibly for an alternative treatment for skin infections.
Active suspension control of electric vehicle with in-wheel motors

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A one-year prospective, randomized, placebo-controlled, quadruple-blinded, phase II safety pilot trial of combination therapy with interferon beta-1a and mycophenolate mofetil in early relapsing—remitting multiple sclerosis (TIME MS)

Background: Mycophenolate mofetil (MMF) is an oral DNA base synthesis inhibitor with immunomodulatory effects on B cells, T cells, and macrophages. Objective: To conduct a safety and tolerability pilot study of interferon beta-1a (IFN-b1a) in combination with either placebo or oral MMF in multiple sclerosis (MS). Methods: Twenty-four treatment-naïve R—RMS patients participated in a one-year prospective, placebo-controlled, blinded, safety pilot clinical trial. Every patient injected weekly intramuscular interferon beta-1a. The cohort was then randomized (1 : 1) to either active oral MMF or identical-appearing placebo tablets. Clinical evaluations were assessed every 3 months, along with brain MRI scans performed at baseline and repeated every 60 days for one year. Comprehensive laboratory assessments were monitored for safety, along with adverse events. Results: In this small pilot investigation, no differences were identified between the two treatment groups with respect to patient-reported adverse events, MRI metrics, or laboratory abnormalities. Notwithstanding these observations, and the limited number of patients treated, trends appeared to favor the combination therapy regimen. Conclusions: The combination treatment regimen of interferon beta-1a and MMF appeared to be well tolerated in this pilot study. Despite the small sample size, therapeutic trends were observed in favor of combination therapy. An adequately powered controlled trial of MMF in MS appears warranted.
Dynamic changes in amygdala activation and functional connectivity in children and adolescents with anxiety disorders

Abstract Anxiety disorders are associated with abnormalities in amygdala function and prefrontal cortex–amygdala connectivity. The majority of functional magnetic resonance imaging studies have examined mean group differences in amygdala activation or connectivity in children and adolescents with anxiety disorders relative to controls, but emerging evidence suggests that abnormalities in amygdala function are dependent on the timing of the task and may vary across the course of a scanning session. The goal of the present study was to extend our knowledge of the dynamics of amygdala dysfunction by examining whether changes in amygdala activation and connectivity over scanning differ in pediatric anxiety disorder patients relative to typically developing controls during an emotion processing task. Examining changes in activation over time allows for a comparison of how brain function differs during initial exposure to novel stimuli versus more prolonged exposure. Participants included 34 anxiety disorder patients and 19 controls 7 to 19 years old. Participants performed an emotional face-matching task during functional magnetic resonance imaging scanning, and the task was divided into thirds in order to examine change in activation over time. Results demonstrated that patients exhibited an abnormal pattern of amygdala activation characterized by an initially heightened amygdala response relative to controls at the beginning of scanning, followed by significant decreases in activation over time. In addition, controls evidenced greater context-modulated prefrontal cortex–amygdala connectivity during the beginning of scanning relative to patients. These results indicate that differences in emotion processing between the groups vary from initial exposure to novel stimuli relative to more prolonged exposure. Implications are discussed regarding how this pattern of neural activation may relate to altered early-occurring or anticipatory emotion-regulation strategies and maladaptive later-occurring strategies in children and adolescents with anxiety disorders.
Functional p53 in cells contributes to the anticancer effect of the cyclin‐dependent kinase inhibitor roscovitine

Inhibitors of cyclin‐dependent kinases (CDKs) undergoing clinical trials as anticancer agents usually target several CDKs in cells. Some of them are also able to increase cellular levels of p53 protein and to activate p53‐regulated transcription. To define the role of p53 in the anticancer effect of selective CDK inhibitors, two related compounds roscovitine and olomoucine II were studied. Roscovitine differs functionally from its congener olomoucine II only in the selectivity towards transcriptional CDK9. Action of both compounds on proliferation, cell‐cycle progression, and apoptosis was examined in RPMI‐8226 cells expressing the temperature‐sensitive mutant of p53 and in MCF‐7 cells with wild‐type p53. Both compounds blocked proliferation, decreased phosphorylation of RNA polymerase II, downregulated antiapoptotic protein Mcl‐1 in both cell lines in a dose‐dependent manner, and also activated p53 in MCF‐7 cells. Moreover, we showed that the anticancer efficiency of CDK inhibitors was enhanced by active p53 in RPMI‐8226 cells kept at permissive temperature, where downregulation of Mcl‐1, fragmentation of PARP‐1, and increased caspase‐3 activity was detected with lower doses of the compounds. The results confirm that functional p53 protein may enhance the anticancer activity of roscovitine that could be beneficial for anticancer therapy. J. Cell. Biochem. 107: 428–437, 2009. © 2009 Wiley‐Liss, Inc.
DBTaint: Cross-Application Information Flow Tracking via Databases

Information flow tracking has been an effective approach for identifying malicious input and detecting software vulnerabilities. However, most current schemes can only track data within a single application. This single-application approach means that the program must consider data from other programs as either all tainted or all untainted, inevitably causing false positives or false negatives. These schemes are insufficient for most Web services because these services include multiple applications, such as a Web application and a database application. Although system-wide information flow tracking is available, these approaches are expensive and overkill for tracking data between Web applications and databases because they fail to take advantage of database semantics. We have designed DBTaint, which provides information flow tracking in databases to enable cross-application information flow tracking. In DBTaint, we extend database datatypes to maintain and propagate taint bits on each value. We integrate Web application and database taint tracking engines by modifying the database interface, providing cross-application information flow tracking transparently to the Web application. We present two prototype implementations for Perl and Java Web services, and evaluate their effectiveness on two real-worldWeb applications, an enterprise-grade application written in Perl and a robust forum application written in Java. By taking advantage of the semantics of database operations, DBTaint has low overhead: our un-optimized prototype incurs less than 10-15% overhead in our benchmarks.
Evaluating HeLI with Non-Linear Mappings

In this paper we describe the non-linear mappings we used with the Helsinki language identification method, HeLI, in the 4th edition of the Discriminating between Similar Languages (DSL) shared task, which was organized as part of the VarDial 2017 workshop. Our SUKI team participated on the closed track together with 10 other teams. Our system reached the 7th position in the track. We describe the HeLI method and the non-linear mappings in mathematical notation. The HeLI method uses a probabilistic model with character n-grams and word-based backoff. We also describe our trials using the non-linear mappings instead of relative frequencies and we present statistics about the back-off function of the HeLI method.
Characterization of CIA-1, an Ambler Class A Extended-Spectrum β-Lactamase from Chryseobacterium indologenes

ABSTRACT An Ambler class A β-lactamase gene, blaCIA-1, was cloned from the reference strain Chryseobacterium indologenes ATCC 29897 and expressed in Escherichia coli BL21. The blaCIA-1 gene encodes a novel extended-spectrum β-lactamase (ESBL) that shared 68% and 60% identities with the CGA-1 and CME-1 β-lactamases, respectively. blaCIA-1-like genes were detected from clinical isolates. In addition to the metallo-β-lactamase IND of Ambler class B, C. indologenes has a class A ESBL gene, blaCIA-1, located on the chromosome.