Miracle-dz/UniFAR-FTUs huggingface dataset:
Disability-Adjusted Life Years among Drug Users in Khon Kaen: An Evidence-Based Approach.

OBJECTIVE To examine the Disability Adjusted Life Years (DALYs) among drug users in Khon Kaen. MATERIAL AND METHOD A cross-sectional descriptive study was conducted between January 2014 and February 2015. Patients' medical records, supported by the Khon Kaen Provincial Public Health Office, were used for data regarding the treatment ofthe drug users between October 2013 and September 2014. SPSS version 19.0 for windows was used to analyze descriptive statistics and Pearson's correlations. RESULTS A review of medical records revealed a total number of drug users were 3,605 males (92.25%) and 303 females (7.75%). A total of 2,195 cases (56.17%) were drug dependence. 20 drug users died due to drug-related causes. A total DALYs were 6,772.26 and a prevalence rate of DALYs was 3.76/1,000 populations. The correlation analyses showed significantly factors related to the DALYs among drug users were age, occupation, pattern of drug use, levels of severity, drug-related death and treatment services. CONCLUSION The DALYs were apparently high among male drug users, who completed primay school education, were drug-dependent and being treated in group therapy. The health authorities may use these associated factors in order to develop or improve programs related to prevention, harm reduction and treatment services effectively.
Resonance-induced multimodal body-size distributions in ecosystems

The size of an organism reflects its metabolic rate, growth rate, mortality, and other important characteristics; therefore, the distribution of body size is a major determinant of ecosystem structure and function. Body-size distributions often are multimodal, with several peaks of abundant sizes, and previous studies suggest that this is the outcome of niche separation: species from distinct peaks avoid competition by consuming different resources, which results in selection of different sizes in each niche. However, this cannot explain many ecosystems with several peaks competing over the same niche. Here, we suggest an alternative, generic mechanism underlying multimodal size distributions, by showing that the size-dependent tradeoff between reproduction and resource utilization entails an inherent resonance that may induce multiple peaks, all competing over the same niche. Our theory is well fitted to empirical data in various ecosystems, in which both model and measurements show a multimodal, periodically peaked distribution at larger sizes, followed by a smooth tail at smaller sizes. Moreover, we show a universal pattern of size distributions, manifested in the collapse of data from ecosystems of different scales: phytoplankton in a lake, metazoans in a stream, and arthropods in forests. The demonstrated resonance mechanism is generic, suggesting that multimodal distributions of numerous ecological characters emerge from the interplay between local competition and global migration.
Cascade of failures in coupled network systems with multiple support-dependent relations

We study, both analytically and numerically, the cascade of failures in two coupled network systems A and B, where multiple support-dependence relations are randomly built between nodes of networks A and B. In our model we assume that each node in one network can function only if it has at least a single support link connecting it to a functional node in the other network. We assume that networks A and B have (i) sizes N{A} and N{B}, (ii) degree distributions of connectivity links P{A}(k) and P{B}(k), (iii) degree distributions of support links P̃{A}(k) and P̃{B}(k), and (iv) random attack removes (1-R{A})N{A} and (1-R{B})N{B} nodes form the networks A and B, respectively. We find the fractions of nodes μ{∞}{A} and μ{∞}{B} which remain functional (giant component) at the end of the cascade process in networks A and B in terms of the generating functions of the degree distributions of their connectivity and support links. In a special case of Erdős-Rényi networks with average degrees a and b in networks A and B, respectively, and Poisson distributions of support links with average degrees ã and b̃ in networks A and B, respectively, μ{∞}{A}=R{A}[1-exp(-ãμ{∞}{B})][1-exp(-aμ{∞}{A})] and μ{∞}{B}=R{B}[1-exp(-b̃μ{∞}{A})][1-exp(-bμ{∞}{B})]. In the limit of ã→∞ and b̃→∞, both networks become independent, and our model becomes equivalent to a random attack on a single Erdős-Rényi network. We also test our theory on two coupled scale-free networks, and find good agreement with the simulations.
Object pronouns, clitics, and omissions in child Polish and Ukrainian

ABSTRACT Polish and Ukrainian pattern together syntactically in allowing various omissions in the same discourse settings, for example, when the referring element has been mentioned in a previous context. However, Ukrainian employs full object pronouns morphologically, whereas Polish uses clitics in the same environments. We exploit this contrast to compare the acquisition of clitics versus full pronouns, enriching previous accounts of omissions in child speech. The results of an elicited production experiment reveal that, in the two languages considered, 3- to 6-year-old children make no errors in direct object realization, but prefer to use null arguments up to the age of 5. It is crucial that there is no obvious difference between the acquisition patterns for clitics versus pronouns, which suggests that the morphophonological properties of direct objects are not primary predictors of object realization in languages that allow discourse-related omissions.
Mother–Child Book‐Sharing and Children's Storytelling Skills in Ethnically Diverse, Low‐Income Families

The present study examined book-sharing interactions between mothers and their 4-year-old children from African American (n = 62), Dominican (n = 67), Mexican (n = 59) and Chinese (n = 82) low-income U.S. families, and children's independent storytelling skills one year later. Mothers' book-sharing style was analysed in terms of how much storyline information they provided (story components), the extent to which they asked children about the story (dialogic emphasis) and which features of the story they highlighted (story content). African American mothers referred to more story components than did Dominican mothers, and Mexican mothers surpassed Dominican and Chinese mothers. Mothers of all groups were low in dialogic emphasis; they predominantly narrated rather than asked about the story, although Mexican mothers asked relatively more questions than did African American and Dominican mothers. In terms of content, compared with other groups, African American mothers were most likely to emphasize ‘individual goals’, and Chinese mothers were most likely to emphasize ‘negative consequences’. Latino mothers were more likely to emphasize ‘emotions’ than were Chinese mothers. Children's storytelling styles partially mirrored those seen in their mothers. Mothers' dialogic emphasis related to children's contributions to book-sharing, which in turn predicted children's later independent storytelling skills. Copyright © 2014 John Wiley & Sons, Ltd.
Preliminary Validity and Reliability of Scores on the Self-Determination Inventory: Student Report Version

The purpose of this article is to describe preliminary psychometric characteristics of a student self-report measure of self-determination, the Self-Determination Inventory: Student Report version (SDI-SR), designed for youth with and without disabilities. We administered the draft assessment to 311 youth and examined item functioning using structural equation modeling and item response theory. The 50 items that demonstrated strong psychometric properties were examined for construct validity using a series of confirmatory factor analyses. Overall, the pilot measure aligned well with the theoretical framework that guided its development, demonstrating acceptable model fit in adolescents with and without disabilities. Implications for further development and practice are discussed.
Analysis of Investor Behavior in an Artificial Stock Market

Abstract: Building upon previous work in the field of behavioral finance and artificial stock markets, a model incorporating discrete and continuous interrelations is developed. Three different investor types are modeled as individual agents: fundamental analysts, technical analysts and noise traders. They differ in their intrinsic pricing mechanism and represent trading strategies that are observed in financial markets. The developed structure is able to reproduce the formation of speculative bubbles and other stochastical anomalies that are characteristic for financial time series.
Primary cutaneous immunocytoma: report of an unusual case with secondary spreading to the gastrointestinal tract

Cutaneous immunocytoma are low‐grade B‐cell lymphomas, which affect the skin either primarily or secondarily. Primary cutaneous immunocytomas usually present with one or a small number of lesions, mainly in the extremities. They generally remain confined to the skin. Histologically, there are polymorphous infiltrates of cells, in which the presence of monoclonal plasma cells is characteristic. We describe a case of cutaneous immunocytoma with secondary spread to the gastrointestinal tract.
Early Developmental Outcome in Children With Hypoplastic Left Heart Syndrome and Related Anomalies: The Single Ventricle Reconstruction Trial

Background— Survivors of the Norwood procedure may experience neurodevelopmental impairment. Clinical trials to improve outcomes have focused primarily on methods of vital organ support during cardiopulmonary bypass. Methods and Results— In the Single Ventricle Reconstruction trial of the Norwood procedure with modified Blalock-Taussig shunt versus right-ventricle-to-pulmonary-artery shunt, 14-month neurodevelopmental outcome was assessed by use of the Psychomotor Development Index (PDI) and Mental Development Index (MDI) of the Bayley Scales of Infant Development-II. We used multivariable regression to identify risk factors for adverse outcome. Among 373 transplant-free survivors, 321 (86%) returned at age 14.3±1.1 (mean±SD) months. Mean PDI (74±19) and MDI (89±18) scores were lower than normative means (each P<0.001). Neither PDI nor MDI score was associated with type of Norwood shunt. Independent predictors of lower PDI score (R2=26%) were clinical center (P=0.003), birth weight <2.5 kg (P=0.023), longer Norwood hospitalization (P<0.001), and more complications between Norwood procedure discharge and age 12 months (P<0.001). Independent risk factors for lower MDI score (R2=34%) included center (P<0.001), birth weight <2.5 kg (P=0.04), genetic syndrome/anomalies (P=0.04), lower maternal education (P=0.04), longer mechanical ventilation after the Norwood procedure (P<0.001), and more complications after Norwood discharge to age 12 months (P<0.001). We found no significant relationship of PDI or MDI score to perfusion type, other aspects of vital organ support (eg, hematocrit, pH strategy), or cardiac anatomy. Conclusions— Neurodevelopmental impairment in Norwood survivors is more highly associated with innate patient factors and overall morbidity in the first year than with intraoperative management strategies. Improved outcomes are likely to require interventions that occur outside the operating room. Clinical Trial Registration— URL: http://www.clinicaltrials. gov. Unique identifier: NCT00115934.
Cytogenetical analysis of the germ cell in the domestic drake and mule drake.

Experiments were conducted to study the germ cell of testes in the domestic drake (Tsaiya drake) and the mule drake. The histological sections of testes of both drakes were compared in this study. The results showed that rapid testicular growth did not occur until 7 weeks of age in domestic drakes and 15 weeks of age in the mule drakes. The rate of growth of the testes and the increase in the ratio of testes weight to body weight in domestic drakes at different ages were much more rapid than in the mule drakes. However, the opposite results were found in the body weights. In the mule drakes, spermatogonia and primary spermatocytes could be observed in the seminiferous tubules, but no secondary spermatocytes, spermatids or spermatozoa in seminiferous tubules were found up to 52 weeks of age. This showed that the meiotic division had not occurred in the mule drakes. In the domestic drakes, spermatogonia in the seminiferous tubules were observed at 1 week of age. Primary spermatocytes of some males appeared as early as the third week of age. Secondary spermatocytes and spermatids in the seminiferous tubules of some drakes began to appear at 5 weeks of age as a result of the meiotic division of the spermatocytes. At 7 weeks of age, spermatids were in process of metamorphosis, and spermatozoa were first observed in the seminiferous tubules of the drake. All testes of drakes 9 weeks of age contained spermatozoa. The percentage of the seminiferous tubules containing spermatozoa increased gradually with age, and approached a plateau at 15 weeks of age. (ABSTRACT TRUNCATED AT 250 WORDS)
Solid-state 2H NMR relaxation illuminates functional dynamics of retinal cofactor in membrane activation of rhodopsin

Rhodopsin is a canonical member of the family of G protein-coupled receptors, which transmit signals across cellular membranes and are linked to many drug interventions in humans. Here we show that solid-state 2H NMR relaxation allows investigation of light-induced changes in local ps–ns time scale motions of retinal bound to rhodopsin. Site-specific 2H labels were introduced into methyl groups of the retinal ligand that are essential to the activation process. We conducted solid-state 2H NMR relaxation (spin-lattice, T1Z, and quadrupolar-order, T1Q) experiments in the dark, Meta I, and Meta II states of the photoreceptor. Surprisingly, we find the retinylidene methyl groups exhibit site-specific differences in dynamics that change upon light excitation—even more striking, the C9-methyl group is a dynamical hotspot that corresponds to a crucial functional hotspot of rhodopsin. Following 11-cis to trans isomerization, the 2H NMR data suggest the β-ionone ring remains in its hydrophobic binding pocket in all three states of the protein. We propose a multiscale activation mechanism with a complex energy landscape, whereby the photonic energy is directed against the E2 loop by the C13-methyl group, and toward helices H3 and H5 by the C5-methyl of the β-ionone ring. Changes in retinal structure and dynamics initiate activating fluctuations of transmembrane helices H5 and H6 in the Meta I–Meta II equilibrium of rhodopsin. Our proposals challenge the Standard Model whereby a single light-activated receptor conformation yields the visual response—rather an ensemble of substates is present, due to the entropy gain produced by photolysis of the inhibitory retinal lock.
The Relationship of Psychological Separation and Parental Attachment to the Career Maturity of College Freshmen from Intact Families

This study was designed to investigate how psychological separation and parental attachment are related to career maturity separately and simultaneously and to investigate the influence of gender on the relationships among these variables. Subjects were 82 single white college freshmen from intact families. Data analysis using a canonical correlation analysis revealed that although psychological separation is relevant, parental attachment plays a more important role in career maturity. The relationship among the variables did not differ for men and women. The implications of this study for theory and counseling practice are discussed and recommendations for future research are presented.
Epidermal Growth Factor (EGF) Receptor Kinase-independent Signaling by EGF*

The ErbB family of receptors, which includes the epidermal growth factor receptor (EGFR), ErbB2, ErbB3, and ErbB4, mediate signaling by EGF-like polypeptides. To better understand the role of the EGFR tyrosine kinase, we analyzed signaling by a kinase-inactive EGFR (K721M) in ErbB-devoid 32D cells. K721M alone exhibited no detectable signaling capacity, whereas coexpression of K721M with ErbB2, but not ErbB3 or ErbB4, resulted in EGF-dependent mitogen-activated protein kinase (MAPK) activation. The kinase activity, but not tyrosine phosphorylation, of ErbB2 was required for EGF-induced MAPK activation. The presence of tyrosine phosphorylation sites in K721M was not a requisite for signaling, indicating that transphosphorylation of K721M by ErbB2 was not an essential mechanism of receptor activation. Conversely, the mutated kinase domain of K721M (residues 648–973) and tyrosine phosphorylation of at least one of the receptors were necessary. EGF was found to activate the pro-survival protein kinase Akt in stable cell lines expressing K721M and ErbB2 but, unlike cells expressing wild-type EGFR, was incapable of activating signal transducers and activators of transcription (STAT) or driving cell proliferation. These results demonstrate that EGFR-ErbB2 oligomers are potent activators of MAPK and Akt, and this signaling does not require EGFR kinase activity.
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At interfaces between different fluids, properties such as density, viscosity, and molecular cohesion are discontinuous. To animate small-scale details of incompressible viscous multi-phase fluids realistically, we focus on the discontinuities in the state variables that express these properties. Surface tension of both free and bubble surfaces is modeled using the jump condition in the pressure field; and discontinuities in the velocity gradient field, driven by viscosity differences, are also considered. To obtain derivatives of the pressure and velocity fields with sub-grid accuracy, they are extrapolated across interfaces using continuous variables based on physical properties. The numerical methods that we present are easy to implement and do not impact the performance of existing solvers. Small-scale fluid motions, such as capillary instability, breakup of liquid sheets, and bubbly water can all be successfully animated.
Genetic and environmental contributions to alcohol abuse and dependence in a population-based sample of male twins.

OBJECTIVE Most twin and adoption studies of alcoholism have ascertained cases through treatment settings or archival data; these subjects may differ from affected subjects identified epidemiologically. The authors studied the importance of genetic influences on risk of alcohol-related disorders in a new population-based twin sample. METHOD Structured personal interviews were used to assess DSM-III-R-defined and DSM-IV-defined alcohol abuse and dependence among 3,516 twins from male-male pairs born in Virginia between 1940 and 1974. RESULTS The magnitude of resemblance among twin pairs was similar across several definitions of alcoholism and was substantially higher among 861 identical pairs than among 653 fraternal pairs. On the basis of a liability threshold model, 48%-58% of the variation in liability was attributed to additive genetic factors, with the remainder attributed to environmental influences not shared by family members. When a treatment-based proband concordance model was used, evidence for shared environmental as well as genetic influences emerged. CONCLUSIONS In this first population-based study of male twins from the United States, it was found that genetic factors played a major role in the development of alcoholism among males, with similar influence for alcohol abuse and alcohol dependence. Prior findings implicating the influence of common environment may be attributable to sampling strategy; in this population-based sample, environmental factors shared by family members appear to have had little influence on the development of alcoholism in males.
The Use of Critical Success Factors in Evaluation of Information Systems: A Case Study

Abstract:This paper discusses the application of the Critical Success Factor (csf) method as a way of evaluating the information available for planning and control activities. Using a questionnaire in addition to individual interviews and group meetings to collect data on the Critical Success Factors, Rockart’s method was successfully applied to assess the availability of critical information needed by the management of a multi-institutional health care arrangement. Results indicated large differences in the information needs of the management team evaluated. The added value of the work is the insights gained by using multiple methods within a general csf concept. The csf method is recommended to perform the evaluation of the information function in the context of evaluative research.
Isolation and characterization of the major form of polyprenyl-phospho-mannose from Mycobacterium smegmatis.

We isolated from the endogenous polyprenyl-phospho-sugar pool of Mycobacterium smegmatis two mannose-containing compounds, i.e., a partially saturated C35-octahydroheptaprenyl-P-mannose and a fully unsaturated C50-decaprenyl-P-mannose. The relative amount of C35-polyprenyl-P-mannose in mycobacterial cells was comparable to that of decaprenyl- P-pentoses and, at least, an order of magnitude higher than that of C50-decaprenyl-P-mannose. The major form of mycobacterial polyprenyl-P-mannose was structurally characterized by combined gas chromatography-mass spectrometry, fast-atom bombardment tandem mass spectrometry and proton-nuclear magnetic resonance spectroscopy as beta-d-mannopyranosyl-monophospho-(C35)octahydroheptapren ol of which all three isoprene units have Z ( cis ) configuration. The differences in the structure and cellular concentrations of the mycobacterial mannosyl-P-polyprenols reflect distinct biochemical pathways of the two compounds and suggest the existence of specific GDP-Man:polyprenyl-P mannosyltransferases (synthetases) able to distinguish between C35-octahydroheptaprenyl- and C50-decaprenyl- phosphates of mycobacteria. Since the 6'-O-mycoloylated form of C35-octahydroheptaprenyl-P-mannose isolated from M. smegmatis is apparently involved in mycolate rather than mannosyl transfer reactions, we speculate that a catabolic pathway responsible for degradation of C35-P-mannose and recycling C35-octahydroheptaprenyl phosphate might exist in mycobacteria.
A Vision Based Approach to Wireless Optical Networking

In this paper, we present a new approach to wireless optical networking. In contrast to traditional laser/photo-di o e based transceivers, our model relies upon a standard CCD video camera to segment bit patterns through image processing techniques. In our current implementation, network packets are ”transmitted” via screen updates to an LCD display. In preliminary experiments, a maximum continuous throughput of 52.0 kbps was demonstrated using a standard NTSC camera. Transmissions over a distance of 30 feet (9 meters) were also achieved by employing an 18X optical zoom lens assembly. We believe that this approach provides not only a redundant, secure means for wireless communication, but also a medium for enabling networking through non-traditional devices (e.g., television monito rs) widely available throughout the current infrastructure.
Encoding Pheromonal Signals in the Accessory Olfactory Bulb of Behaving Mice

Many mammalian species rely on pheromones—semiochemicals produced by other members of the same species—to communicate social status and reproductive readiness. To assess how the central nervous system integrates the complex repertoire of pheromones, we recorded from single neurons in the accessory olfactory bulb, a nucleus that processes pheromonal signals, of male mice engaged in natural behaviors. Neuronal firing was robustly modulated by physical contact with male and female conspecifics, with individual neurons activated selectively by specific combinations of the sex and strain of conspecifics. We infer that mammals encode social and reproductive information by integrating vomeronasal sensory activity specific to sex and genetic makeup.