Miracle-dz/UniFAR-FTUs huggingface dataset:
Apprendre à mieux vivre ensemble. Des écoles en santé pour la réussite de tous.

Profondement ancree dans les valeurs de l'ecole, l'approche apprendre a mieux vivre ensemble concerne les activites de classe, la relation ecole-famille et le climat scolaire. Elle a pour objectif d'ameliorer le climat scolaire et le bien-etre a l'ecole afin de favoriser la reussite de tous les eleves. Elle vise a valoriser, a mutualiser et a enrichir les pratiques des ecoles dans le domaine de l'education a la sante et a la citoyennete. Apprendre a mieux vivre ensemble s'adresse aux equipes d'ecole mais aussi aux parents, aux professionnels des collectivites territoriales et du monde de la sante comme aux acteurs associatifs. Il s'agit de permettre le developpement, chez les eleves, des connaissances et des competences et du socle commun, en leur donnant les moyens de : - connaitre leur corps, leur sante, les comportements et leurs effets : le corps, son fonctionnement et ses besoins ; savoir prendre soin de soi et des autres. - developper leurs competences personnelles, sociales et civiques : les regles de la vie collective ; le respect de soi et des autres ; avoir confiance en soi et s'affirmer de maniere constructive ; savoir gerer les conflits, echanger et cooperer ; . - acquerir les moyens d'un regard critique vis-a-vis de son environnement : soumettre a critique l'information ; savoir resister a la pression des pairs ; savoir construire son opinion personnelle. L'enjeu est egalement de faire de l'ecole un environnement favorable a la reussite de tous par la promotion de la sante et du bien-etre des eleves comme des adultes, des amenagements adaptes, l'implication des eleves dans la vie de l'ecole et la collaboration avec les parents et la communaute locale. Cet ouvrage est le fruit d'un travail collectif qui mobilise depuis 2003 des enseignants, des parents d'eleves, des inspecteurs, des conseillers pedagogiques, des infirmiers et medecins de sante scolaire, des enseignants specialises et des psychologues scolaires, des elus, des professionnels des collectivites territoriales, du monde de la sante et du reseau associatif ainsi que des chercheurs du laboratoire PAEDI (EA 4281).
Body composition in premanifest Huntington’s disease reveals lower bone density compared to controls.

Huntington’s disease (HD) is a debilitating autosomal dominant, neurodegenerative disease with a fatal prognosis. Classical features include motor disturbances, dementia and psychiatric problems but are not restricted to this triad as patients often experience other abnormalities such as unintended weight loss, the exact cause of which is unknown. We studied the body composition of 25 premanifest HD and compared it to 25 control subjects using a dual energy x-ray absorptiometer (DEXA) scan. Like the R6/2 transgenic mouse model, we identified significantly lower bone mineral density z-scores in premanifest individuals, that was not related to any difference in testosterone, cortisol, leptin or Vitamin D levels. These results identify an early gene-related change that occurs in HD which not only could lead to a potential biomarker for the disease, but given it is also seen in other manifest neurodegenerative diseases, could also reveal a common disease related process.
Development of sensitivity to visual motion in macaque monkeys

The development of spatial vision is relatively well documented in human and nonhuman primates. However, little is known about the development of sensitivity to motion. We measured the development of sensitivity to direction of motion, and the relationship between motion and contrast sensitivity in macaque monkeys as a function of age. Monkeys (Macaca nemestrina, aged between 10 days and 3 years) discriminated direction of motion in random-dot kinematograms. The youngest monkeys showed directionally selective orienting and the ability to integrate motion signals at large dot displacements and fast speeds. With age, coherence sensitivity improved for all spatial and temporal dot displacements tested. The temporal interval between the dots was far less important than the spatial offset in determining the animals' performance at all but the youngest ages. Motion sensitivity improved well beyond the end of the first postnatal year, when mid-spatial-frequency contrast sensitivity reached asymptote, and continued for at least 3 years. Sensitivity to contrast at high spatial frequencies also continued to develop beyond the end of the first year. We conclude that the development of motion sensitivity depends on mechanisms beyond the low-level filters presumed to limit acuity and contrast sensitivity, and most likely reflects the function of extrastriate visual areas.
NanoDisk containing super aggregated amphotericin B: a high therapeutic index antifungal formulation with enhanced potency

Objectives NanoDisk–amphotericin B (ND-AMB) is a protein-phospholipid bioparticle containing a “super aggregate” form of antifungal AMB. While lipid-based formulations of AMB, including liposomal AMB (L-AMB), are safer than the deoxycholate (DOC) solubilized form (DOC-AMB), the potency of lipid-based formulations is attenuated. We have developed an AMB-based therapy that is both well tolerated and fully efficacious. Methods Potency was determined using broth culture growth-inhibition assays and candidacidal kinetics by quantitative culture plating. Toxicology studies were performed in healthy mice. Efficacy was assessed using both immune-competent and leukopenic murine models of systemic Candida albicans infection. Results ND-AMB C. albicans and Aspergillus fumigatus minimum inhibitory concentrations were fourfold and sixfold lower, respectively, than that observed for L-AMB. ND-AMB exhibited candidacidal activity at 0.125 mg/L, 16-fold lower than L-AMB. In mice, ND-AMB produced no statistically significant kidney or liver toxicity at 15 mg/kg, the highest dose tested. When evaluated in immune-competent mice infected with C. albicans, ND-AMB was at least as effective as DOC-AMB or L-AMB. In a leukopenic model of candidiasis, the 50% effective dose of ND-AMB was around threefold lower than L-AMB. Conclusion These results indicate that ND-AMB exhibits a more favorable safety profile while maintaining uncompromised antifungal properties compared to both DOC-AMB and L-AMB. ND-AMB is a promising therapy for the treatment of invasive fungal infections.
Sparse graph embedding dimension reduction for hyperspectral image with a new spectral similarity metric

Graph embedding, as a dimensionality reduction framework, has already drawn great attention in hyperspectral image analysis. Taking locality preserving projection (LPP) as example, LPP utilizes typical Euclidean distance in heat kernel to create an affinity matrix and projects the high-dimensional data into a lower-dimensional space. However, the Euclidean distance is not sufficiently correlated with intrinsic spectral variation of a material, which may result in inappropriate graph representation. In this work, a graph-based discriminant analysis with novel spectral similarity measurement is proposed, which fully considers curves changing description among spectral bands. Experimental results based on real hyperspectral images demonstrate the proposed method is superior to traditional methods, such as supervised LPP, and the state-of-the-art sparse graph-based discriminant analysis (SGDA).
Classification of Concept Drifting Data Streams Using Adaptive Novel-Class Detection

— In data stream classification there are many problems observed by the data mining community. Four major problems are addressed, such as, concept-drift, infinite length, feature-evolution and concept-evolution. Concept-drift occurs when underlying concept changes which is common in data streams. Practically it is not possible to store and use all data for training purpose whenever required due to infinite length of data streams. Feature evolution frequently occurs in many text streams. In text streams new features like words or phrases may occur when stream progresses. New classes evolving in the data stream which occurs concept-evolution as a result. Most existing classification techniques of data stream consider only the first two challenges, and ignore the latter two. Classification of concept-drifting data stream using adaptive novel-class detection approach is used to solve concept-drift and concept-evolution problem where novel-class detector is maintained with classifier. Novel-class detector is more adaptive to the dynamic and evolving data streams. It enables to detect more than one novel-class simultaneously. This approach solves feature-evolution problem by using feature set homogenization technique. Experiments done on Twitter data set and got reduced ERR rate and increased detection rate as a result. This approach is very effective as compared with existing data stream classification techniques.
PRAGMATIC EVALUATION OF TELEPHONES, ACTIVITY SCHEDULING, AND OTHER STRATEGIES TO MODIFY TRAVEL BEHAVIOR OF POPULATION SUBGROUPS (ABRIDGMENT)

Social science literature and information from a comprehensive case study of a population subgroup's physical mobility were used to forecast behavioral responses to 8 strategies to overcome problems associated with urban transportation. Strategies included substituting telephone calls for trip making, reducing family household and personal stresses, reducing tensions from poor home design, increasing home-centered activities, expanding home deliveries of goods and services, increasing spatial distribution of trip generators, improving the household location decision, and rescheduling school and work activities. The case study population was male high school students from working-class Boston suburbs. These strategies appear unlikely to be implemented on a large scale. Formidable opposition from parents, town residents, and institutions (especially in working-class communities) is anticipated. Costs, adult indifference, and a lack of respect for teenagers and the importance of these strategies are key barriers to be overcome. Even if these strategies manage to be implemented, empirical evidence is lacking that reductions in trip generation, trip distances, peak-hour travel, and other strategy objectives will actually occur. Fundamental sociological and psychological factors associated with the causes of travel behavior will remain unchanged. Optimistic predictions of the impacts of these strategies should therefore be avoided. Behavioral changes are likely to occur very slowly among non-middle-class subgroups. Transportation planners should consider trying to accommodate existing behavioral patterns rather than count on their modification.
The Reliability and Stability of Measures about People's Values and Beliefs Concerning Family Life and Social Change

This paper examines the reliability and stability of developmental idealism measures in Nepal. Developmental idealism is a cultural schema that contains beliefs and values favoring modern societies and families over traditional ones and that views modern families as causes and effects of modern societies. It also views the world as dynamic, with change from traditionality towards modernity. Earlier studies have shown that developmental idealism has been disseminated widely internationally, but provide little evidence concerning whether individual views of developmental idealism can be reliably measured or the extent to which such views are stable across time. We estimate reliability and stability of developmental idealism measures using panel data collected in Nepal. Our results indicate substantial levels of reliability, with levels equal to or nearly equal to reliability levels of standard value and belief items measured in general American surveys. There is also considerable stability of developmental idealism views across time. Measures of Values and Beliefs Concerning Family Life and Social Change 3
Integrity of the Pericentriolar Material Is Essential for Maintaining Centriole Association during M Phase

A procentriole is assembled next to the mother centriole during S phase and remains associated until M phase. After functioning as a spindle pole during mitosis, the mother centriole and procentriole are separated at the end of mitosis. A close association of the centriole pair is regarded as an intrinsic block to the centriole reduplication. Therefore, deregulation of this process may cause a problem in the centriole number control, resulting in increased genomic instability. Despite its importance for faithful centriole duplication, the mechanism of centriole separation is not fully understood yet. Here, we report that centriole pairs are prematurely separated in cells whose cell cycle is arrested at M phase by STLC. Dispersal of the pericentriolar material (PCM) was accompanied. This phenomenon was independent of the separase activity but needed the PLK1 activity. Nocodazole effectively inhibited centriole scattering in STLC-treated cells, possibly by reducing the microtubule pulling force around centrosomes. Inhibition of PLK1 also reduced the premature separation of centrioles and the PCM dispersal as well. These results revealed the importance of PCM integrity in centriole association. Therefore, we propose that PCM disassembly is one of the driving forces for centriole separation during mitotic exit.
Identification of prophage genes expressed in lysogens of the Lactococcus lactis bacteriophage BK5-T

Bacteriophage BK5-T is a small isometric-headed temperate phage that infects Lactococcus lactis subsp. cremoris. Northern (RNA) analysis of mRNA produced by lysogenic strains containing BK5-T prophage revealed four major BK5-T transcripts that are 0.8, 1.3, 1.8, and 1.8 kb in size and enabled a transcription map of the prophage genome to be prepared. The position and size of each transcript corresponded closely to the position and size of open reading frames predicted from the nucleotide sequence of BK5-T. Analysis of the transcripts suggested that one of them was derived from the gene encoding the BK5-T integrase and another was from the gene encoding the BK5-T homolog of the lambda cI repressor. Computer analysis of the nucleotide sequence upstream of the BK5-T cI homolog predicted the presence of a pair of divergent promoters and three inverted repeat sequences, features characteristic of temperature-phage immunity regions. By analogy with lambda, the three inverted repeat sequences could be binding sites for cI or Cro homologs and the two divergent promoters could initiate transcription through the BK5-T equivalents of cI and cro.
Hydrogen-Accreting Carbon-Oxygen White Dwarfs of Low Mass: Thermal and Chemical Behavior of Burning Shells

Numerical experiments have been performed to investigate the thermal behavior of a cooled-down white dwarf of initial mass MWD = 0.516 M☉ that accretes hydrogen-rich matter with Z = 0.02 at the rate = 10-8 M☉ yr-1, typical for a recurrent hydrogen shell flash regime. The evolution of the main physical quantities of a model during a pulse cycle is examined in detail. From selected models in the mass range MWD = 0.52-0.68 M☉, we derive the borders in the MWD- plane of the steady state accretion regime when hydrogen is burned at a constant rate as rapidly as it is accreted. The physical properties during a hydrogen shell flash in white dwarfs accreting hydrogen-rich matter with metallicities Z = 0.001 and Z = 0.0001 are also studied. For a fixed accretion rate, a decrease in the metallicity of the accreted matter leads to an increase in the thickness of the hydrogen-rich layer at outburst and a decrease in the hydrogen-burning shell efficiency. In the MWD- plane, the borders of the steady state accretion band are critically dependent on the metallicity of the accreted matter: on decreasing the metallicity, the band is shifted to lower accretion rates and its width in is reduced.
Incremental modelling and verification of the PCI Express transaction layer

PCI Express is a modern, high-performance communication protocol implementing highly sophisticated features to meet today's performance demands. Although an off-chip protocol, PCI Express implements many principles of future on-chip communication architectures. It is a highly complex protocol which is naturally hard to verify formally. We recently proposed a new methodology, based on a series of model transformation steps, to revise the traditional modelling and verification workflow for designing on-chip protocols. We present the application of the new approach to the PCI Express transaction layer. The work has been accomplished in the Isabelle/HOL theorem prover. By restricting the models to an executable subset of the specification language, we have been able to combine the advantages of specifying in a theorem prover with the advantages of executable models in a functional programming language.
Orthodontic treatment need of Yemeni children assessed with dental aesthetic index

Objective: The aim of this study was to estimate the orthodontic treatment need in a sample of 12-year-old Yemeni school children using the dental aesthetic index (DAI). Materials and Methods: The sample comprised 3003, 12-year-old children attending school in six of the governorates of Yemen. For each subject, the standard demographic information such as gender and age was collected, after which an intraoral examination for occlusal status using the DAI was performed. Results: The mean (SD) of DAI score was 24.86 (8.44) points (95% CI, 24.07-25.65). Overall, 36.6% of the sample found to have a dental appearance that requires orthodontic treatment, ranging from ‘selective’ to ‘mandatory’. Of whom, 19.0% presented with severe and handicapping malocclusion, requiring ‘definite’ and “mandatory’ treatment according to the DAI (DAI ≥ 31). Although there was no gender difference in the mean DAI score (P > 0.05), the sex distribution of the DAI treatment categories was significantly different (Chi-square = 13.258, df = 3, P = 0.004). The results of the individual DAI components showed that about 8% of the sample had more than one missing permanent teeth. Anterior maxillary and mandibular irregularity occurred in more than 33% of the sample. More than 30% of the children examined showed signs of crowding. Spacing in the incisal segments occurred in almost 25% of the sample. Almost 30% of the sample had an antero-posterior molar relation discrepancy. Conclusion: According to the findings of this study, almost one in five of the evaluated Yemeni school children had a DAI score above or equal to 31 points, suggesting highly desirable or mandatory orthodontic treatment need.
Intelligently Raising Academic Performance Alerts

We use decision trees and genetic algorithms to analyze the academic performance of students and the homogeneity of tutoring teams in the undergraduate program on Informatics at the Hellenic Open University (HOU). Based on the accuracy of the generated rules, we examine the applicability of the techniques at large and reflect on how one can deploy such techniques in academic performance alert systems.
Research and Social Work Supervision: A Conceptual Review

THE ANNALS OF administrative science have described social work as a supervising profession (Scott, 1965). Indeed, social work practice was built on a foundation of supervision. The belief was that supervised practice would result in better client outcomes (Burns, 1958). That foundation for social work practice became an institu tion. The percentage of social workers with primary or secondary supervisory responsibilities varies between 12.6 and 20 percent, by field of practice (Kadushin, 1976). Using the National Association of Social Workers (NASW, 1987) estimate of 335,465 social workers in the workforce, 42,268 to 67,093 social work supervisors are now in practice. As the scope of social work practice expanded, the purpose of supervision was reconceptualized. After 1938, the focus of supervision shifted from helping clients to training workers. Supervision research using that focus began 20 years later. The research that followed examined supervision with questions about professional develop ment, not client outcomes. Thus, the social work agenda for supervision bypassed client interests. In this article, the authors refocus the examination of supervision and provide a research agenda that focuses on clients. The agenda involves three items: (1) discussing its conceptualiza tion of supervision; (2) reviewing the empirical literature; and (3) asking what supervisory behaviors, of what kind and amount under what conditions, produce what outcomes with what workers, clients, and problems.
Monoclonal antibody against a nuclear matrix antigen in proliferating human cells

A monoclonal antibody of the IgG2a subclass was isolated from the supernate of a hybridoma line obtained with splenocytes from a mouse immunized with a crude nucleolar fraction of human Namalwa cells. This antibody identifies a single nuclear polypeptide antigen characterized by: (a) presence in proliferating human cell lines and phytohemagglutinin‐stimulated lymphocytes, but absence in resting lymphocytes; (b) appearance in stimulated lymphocytes in parallel with the onset of DNA synthesis; (c) a speckled distribution in the nucleoplasm; (d) tight association with nuclear matrix structures identified by both biochemical and in situ extraction and enzyme treatment procedures; (e) mol wt of 125 kDa and pI 6.5 as determined by immunoprecipitation or immunoblotting of nuclear or nuclear matrix proteins fractionated by gel electrophoresis. The above characteristics identify the p125/6.5 nuclear matrix protein recognized by the isolated monoclonal antibody as belonging to the class of proliferating cell nuclear antigens.
Overview of smart metering system in Smart Grid scenario

In Smart Grid, the smart meters are versatile role with intelligent capabilities in order to meet the consumer's demands and their each objective. Smart meter can measure and communicate detailed real time electricity usage, facilitate remote real time monitoring and control power consumptions and consumers are provided with real time pricing and analyzed usage information, which is a technical data to be transmitted to the grid, who are utility providers. More detailed feedback on each appliance to the user. In this connection Demand-side management (DSM) programs implemented by utility companies to control the energy consumption in residences appliances which are interfacing the digital meter with many DSM technical properties and Home energy management system is also implemented for the same cause. A simulation framework that can model a house equipped with various home appliances and the simulator can predict the power dissipation profiles of individual appliances as well as the cumulative energy consumption of the house in a realistic manner, in this process the harmonic pollutions in the electrical networks became one of the major factors affecting the power quality of the network which are detected and for which one of the techniques is two stage solutions for the harmonic analysis by Radial basis function in the neural network. Future smart grids will likely to be more tightly integrated with the cyber infrastructure for sensing, control, scheduling, dispatch, billing and cyber attacks can be detected by using smart meters and also ordering the power demand through online.