Miracle-dz/UniFAR-FTUs huggingface dataset:
An Adaptive Video Streaming Control System: Modeling, Validation, and Performance Evaluation

Adaptive video streaming is a relevant advancement with respect to classic progressive download streaming a la YouTube. Among the different approaches, the video stream-switching technique is getting wide acceptance, being adopted by Microsoft, Apple, and popular video streaming services such as Akamai, Netflix, Hulu, Vudu, and Livestream. In this paper, we present a model of the automatic video stream-switching employed by one of these leading video streaming services along with a description of the client-side communication and control protocol. From the control architecture point of view, the automatic adaptation is achieved by means of two interacting control loops having the controllers at the client and the actuators at the server: One loop is the buffer controller, which aims at steering the client playout buffer to a target length by regulating the server sending rate; the other one implements the stream-switching controller and aims at selecting the video level. A detailed validation of the proposed model has been carried out through experimental measurements in an emulated scenario.
Three-dimensional periodic graphenenanostructures

Graphene is a basic building block for many known and emerging carbon-based materials whose properties largely depend on the way how graphene is structured at the nanoscale. Synthesis of novel three-dimensional (3D) nanostructures of graphene would be an important advance for fundamental research and various applications. In this paper, we discuss the possibility of fabricating complex 3D graphene nanostructures by growing graphene on pre-synthesized nanostructured metal templates by chemical vapor deposition (CVD) and then etching away the metal. In the proof-of-concept experiments, we study this idea using two types of metal nanostructures, inverse opals and slanted nanopillar arrays grown by a glancing angle deposition (GLAD) technique. Due to the elevated temperatures used in typical CVD growth, nanostructures can be easily damaged during the growth process. Therefore, we systematically study the roles of different parameters, such as the composition, morphology and crystallinity of a nanostructured metal, as well as the CVD growth temperature and different carbon sources to grow graphene on metal nanostructures and at the same time preserve their integrity. In particular, we show that nanostructures with large crystalline domains can withstand high temperature CVD, whereas polycrystalline nanostructures, such as nanopillars grown by GLAD, suffer damage even at the low growth temperature of 500 °C. In the case of such thermally sensitive nanostructures, a careful selection of a highly reactive carbon source that could form graphene at lower temperatures becomes crucial. Furthermore, the selection of a metal is also important, as cobalt nanostructures are shown to be more resistant to thermal damage than their nickel counterparts. Finally, we could successfully remove the nanostructured metal templates to form free-standing graphene-based inverse opals and hollow graphene nanopillars. The findings presented in this paper could facilitate synthesis of other 3D graphene nanostructures.
A load shedding scheme for frequent pattern mining in transactional data streams

In this paper, we study overload handling for frequent-pattern mining in online data streams. For a mining system with an e-deficient synopsis based algorithm, we propose a load shedding scheme to deal with the overload situation. The heavy workload of the mining algorithm lies mostly in the great deal of itemsets which need to be enumerated and counted by the mining algorithm. Therefore, our proposed scheme of load shedding involves the maintenance of a smaller set of itemsets, so the workload can be lessened accordingly. The unrecorded itemsets can be fast approximated for their counts when necessary. According to experimental results, the load shedding scheme can increase the throughput of the mining system and thus help manage the overload problem effectively to a certain extent.
Current Trends in Technology and Science

Image analysis is the extraction of meaningful information from images; mainly from digital images by harnessing image processing techniques. Digital image processing allows the use of complex algorithms, and offers more sophisticated performance at simple tasks. We are developing a system for retrieving information from digital document images which is later stored on a database. Preprocessing of an image includes binarization and for this, we are using Maximum Entropy method. Optical Character Recognition (OCR) is a technology for converting scanned papers, digital photos and PDF files to text documents which can be edited. OCR is used to detect text from images which is then processed.
Vitamin D: its role and uses in immunology 1

In recent years there has been an effort to understand possible noncalcemic roles of vitamin D, including its role in the immune system and, in particular, on T cell‐medicated immunity. Vitamin D receptor is found in significant concentrations in the T lymphocyte and macrophage populations. However, its highest concentration is in the immature immune cells of the thymus and the mature CD‐8 T lymphocytes. The significant role of vitamin D compounds as selective immunosuppressants is illustrated by their ability to either prevent or markedly suppress animal models of autoimmune disease. Results show that 1,25‐dihy‐droxyvitamin D3 can either prevent or markedly suppress experimental autoimmune encephalomyelitis, rheumatoid arthritis, systemic lupus erythematosus, type I diabetes, and inflammatory bowel disease. In almost every case, the action of the vitamin D hormone requires that the animals be maintained on a normal or high calcium diet. Possible mechanisms of suppression of these autoimmune disorders by the vitamin D hormone have been presented. The vitamin D hormone stimulates transforming growth factor TGFβ‐1 and interleukin 4 (IL‐4) production, which in turn may suppress inflammatory T cell activity. In support of this, the vitamin D hormone is unable to suppress a murine model of the human disease multiple sclerosis in IL‐4‐deficient mice. The results suggest an important role for vitamin D in autoimmune disorders and provide a fertile and interesting area of research that may yield important new therapies. —DeLuca, H. F. , Cantorna, M. T. Vitamin D: its role and uses in immunology. FASEB J. 15, 2579–2585 (2001)
Caveolin-1 regulates chemokine receptor 5-mediated contribution of bone marrow-derived cells to dermal fibrosis

In fibrotic diseases caveolin-1 underexpression in fibroblasts results in collagen overexpression and in monocytes leads to hypermigration. These profibrotic behaviors are blocked by the caveolin-1 scaffolding domain peptide (CSD) which compensates for caveolin-1 deficiency. Monocytes and fibroblasts are related in that monocytes are the progenitors of fibrocytes (CD45+/Collagen I+ cells) that, in turn, are the progenitors of many fibroblasts in fibrotic tissues. In an additional anti-fibrotic activity, CSD blocks monocyte differentiation into fibrocytes. We studied a mouse fibrosis model (Pump Model) involving systemic bleomycin delivery that closely models scleroderma (SSc) in several ways, the most important of which for this study is that fibrosis is observed in the lungs, skin, and internal organs. We show here that dermal thickness is increased 2-fold in the Pump Model and that this effect is almost completely blocked by CSD (p < 0.001). Concomitantly, the subcutaneous fat layer becomes >80% thinner. This effect is also blocked by CSD (p < 0.001). Even in mice receiving vehicle instead of bleomycin, CSD increases the thickness of the fat layer. To study the mechanisms of action of bleomycin and CSD, we examined the accumulation of the chemokine receptor CCR5 and its ligands MIP1α and MIP1β in fibrotic tissue and their roles in monocyte migration. Fibrocytes and other leukocytes expressing CCR5 and its ligands were present at high levels in the fibrotic dermis of SSc patients and Pump Model mice while CSD blocked their accumulation in mouse dermis. Migration toward CCR5 ligands of SSc monocytes and Pump Model bone marrow cells was 3-fold greater than cells from control subjects. This enhanced migration was almost completely blocked by CSD. These results suggest that low monocyte caveolin-1 promotes fibrosis by enhancing the recruitment of fibrocytes and their progenitors into affected tissue.
Stroke Correlates in Chagasic and Non-Chagasic Cardiomyopathies

Background Aging and migration have brought changes to the epidemiology and stroke has been shown to be independently associated with Chagas disease. We studied stroke correlates in cardiomyopathy patients with focus on the chagasic etiology. Methodology/Principal Findings We performed a cross-sectional review of medical records of 790 patients with a cardiomyopathy. Patients with chagasic (329) and non-chagasic (461) cardiomyopathies were compared. There were 108 stroke cases, significantly more frequent in the Chagas group (17.3% versus 11.1%; p<0.01). Chagasic etiology (odds ratio [OR], 1.79), pacemaker (OR, 2.49), atrial fibrillation (OR, 3.03) and coronary artery disease (OR, 1.92) were stroke predictors in a multivariable analysis of the entire cohort. In a second step, the population was split into those with or without a Chagas-related cardiomyopathy. Univariable post-stratification stroke predictors in the Chagas cohort were pacemaker (OR, 2.73), and coronary artery disease (CAD) (OR, 2.58); while atrial fibrillation (OR, 2.98), age over 55 (OR, 2.92), hypertension (OR, 2.62) and coronary artery disease (OR, 1.94) did so in the non-Chagas cohort. Chagasic stroke patients presented a very high frequency of individuals without any vascular risk factors (40.4%; OR, 4.8). In a post-stratification logistic regression model, stroke remained associated with pacemaker (OR, 2.72) and coronary artery disease (OR, 2.60) in 322 chagasic patients, and with age over 55 (OR, 2.38), atrial fibrillation (OR 3.25) and hypertension (OR 2.12; p = 0.052) in 444 non-chagasic patients. Conclusions/Significance Chagas cardiomyopathy presented both a higher frequency of stroke and an independent association with it. There was a high frequency of strokes without any vascular risk factors in the Chagas as opposed to the non-Chagas cohort. Pacemaker rhythm and CAD were independently associated with stroke in the Chagas group while age over 55 years, hypertension and atrial fibrillation did so in the non-Chagas cardiomyopathies.
Comparison of the proliferation, migration and angiogenic properties of human amniotic epithelial and mesenchymal stem cells and their effects on endothelial cells

In vivo studies have shown that amnion-produced growth factors participate in many diseases that involve angiogenesis, re-epithelialization and immunomodulation. Although human amniotic epithelial cells (hAECs) and human amniotic mesenchymal stem cells (hAMSCs) can be obtained from amniotic membranes, there is little information regarding their biological differences. The aim of the present study was to isolate and characterize cells from human amnions, to investigate the biological potential and behavior of these cells on the function of endothelial cells in vivo and in vitro and to examine variations in the expression profile of growth factors in different human amnion-derived cell types. Amnion fragments were enzymatically digested into two cell fractions, which were analyzed by mesenchymal and epithelial cell markers. Human aortic endothelial cells (hAoECs) were cultured with conditioned medium (CdM) collected from hAECs or hAMSCs. We used scratch and Transwell assays to evaluate migration ability; Cell Counting Kit-8 (CCK-8) and cell cycle analysis to evaluate proliferation ability; and a Matrigel tube formation assay to evaluate angiogenesis ability. To detect expression of angiogenesis-related genes, qPCR and enzyme-linked immunosorbent assay (ELISA) analyses were conducted. As stem cells, hAECs and hAMSCs all expressed the stem cell markers SSEA-4, OCT-4 and SOX-2. CdM obtained from hAECs promoted cell migration; CdM obtained from hAMSCs promoted cell proliferation; CdM obtained from hAECs and hAMSCs both promoted angiogenesis in hAoECs. Amnion-derived cells secreted significant amounts of angiogenic factors including HGF, IGF-1, VEGF, EGF, HB-EGF and bFGF, although differences in the cellular expression profile of these soluble factors were observed. Our results highlight that human amniotic epithelial and mesenchymal stem cells, which showed differences in their soluble factor secretion and angiogenic functions, could be ideal cell sources for regenerative medicine.
Electrochemical inhibitor injection for control of reinforcement corrosion in carbonated concrete

This paper describes preliminary investigations into the effectiveness of an electrochemical method of injecting organic base corrosion inhibitors into carbonated concrete containing embedded steel bars on which corrosion had been pre‐initiated. The corrosion inhibitors studied were pure compounds of ethanolamine (pKa ∼ 9.5) and guanidine (pKa ∼ 13.6). They were injected from aqueous solutions placed in contact with the surfaces of the water‐saturated concrete specimens by applying constant current electrolysis between anodes located within the inhibitor solutions and embedded steel bars acting as cathodes. The concentration profiles of the inhibitors penetrating the concrete cover were examined and the influence of the various treatments on the corrosion rates of the embedded steel bars was estimated by linear polarisation resistance measurements, carried out repeatedly during exposure of the treated specimens to cyclic wetting and drying over several months. The stability of the concentration profiles of the inhibitors was evaluated and measurements of corrosion weight losses of the steel bars were also undertaken on completion of the exposure regimes. It was found that the specimens treated with the inhibitors showed significantly reduced corrosion when compared with untreated control specimens that were subjected to similar exposure.
Nanoparticles Effectively Target Rapamycin Delivery to Sites of Experimental Aortic Aneurysm in Rats

Several drugs targeting the pathogenesis of aortic aneurysm have shown efficacy in model systems but not in clinical trials, potentially owing to the lack of targeted drug delivery. Here, we designed a novel drug delivery system using nanoparticles to target the disrupted aortic aneurysm micro-structure. We generated poly(ethylene glycol)-shelled nanoparticles incorporating rapamycin that exhibited uniform diameter and long-term stability. When injected intravenously into a rat model in which abdominal aortic aneurysm (AAA) had been induced by infusing elastase, labeled rapamycin nanoparticles specifically accumulated in the AAA. Microscopic analysis revealed that rapamycin nanoparticles were mainly distributed in the media and adventitia where the wall structures were damaged. Co-localization of rapamycin nanoparticles with macrophages was also noted. Rapamycin nanoparticles injected during the process of AAA formation evinced significant suppression of AAA formation and mural inflammation at 7 days after elastase infusion, as compared with rapamycin treatment alone. Correspondingly, the activities of matrix metalloproteinases and the expression of inflammatory cytokines were significantly suppressed by rapamycin nanoparticle treatment. Our findings suggest that the nanoparticle-based delivery system achieves specific delivery of rapamycin to the rat AAA and might contribute to establishing a drug therapy approach targeting aortic aneurysm.
Skin lesions - an indicator of disease activity in systemic lupus erythematosus?

Cutaneous manifestations have great diagnostic value for systemic lupus erythematosus (SLE). In this study we tried to establish a correlation between lupus erythematosus LE-specific and LE-nonspecific cutaneous lesions and disease activity measured by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Sixty-six patients with SLE were evaluated. They were divided into three groups having: (1) only LE-specific lesions (38 or 58.46%); (2) only LE-nonspecific lesions (4 or 6.15%); and (3) both types of lesions (23 or 35.38%). Results were analyzed using the Student t-test. Patients with LE-nonspecific skin manifestations had significantly increased disease activity compared to those with only LE-specific lesions. The number of different skin lesion types also correlated with disease activity. It was significantly increased in a group with three different types of lesion, either specific or nonspecific. Patients with only one type of lesion had mild disease. An intermediate disease activity was found in the group with two different lesion types. Lupus-specific skin manifestations serve primarily as an important diagnostic clue. In conclusion, patients with LE-nonspecific lesions have significantly more active SLE than those with LE-specific lesions and may therefore require more intensive therapy and disease monitoring.
Human PAD4 Regulates Histone Arginine Methylation Levels via Demethylimination

Methylation of arginine (Arg) and lysine residues in histones has been correlated with epigenetic forms of gene regulation. Although histone methyltransferases are known, enzymes that demethylate histones have not been identified. Here, we demonstrate that human peptidylarginine deiminase 4 (PAD4) regulates histone Arg methylation by converting methyl-Arg to citrulline and releasing methylamine. PAD4 targets multiple sites in histones H3 and H4, including those sites methylated by coactivators CARM1 (H3 Arg17) and PRMT1 (H4 Arg3). A decrease of histone Arg methylation, with a concomitant increase of citrullination, requires PAD4 activity in human HL-60 granulocytes. Moreover, PAD4 activity is linked with the transcriptional regulation of estrogen-responsive genes in MCF-7 cells. These data suggest that PAD4 mediates gene expression by regulating Arg methylation and citrullination in histones.
Human myeloma in vitro colony growth: interrelationships between drug sensitivity, cell kinetics, and patient survival duration.

Ninety-seven patients with multiple myeloma evaluated serially had both a tritiated thymidine labeling index of bone marrow plasma cells (LI%) and in vitro myeloma stem cell culture performed. Thirty-three patients with myeloma colony growth had in vitro drug sensitivity testing carried out, 18 having in addition in vitro thymidine suicide determinations. The LI% and the likelihood of in vitro myeloma colony growth were highly correlated: the higher the LI%, the more likely was colony or cluster growth (p less than 0.001). The tritiated thymidine suicide of myeloma stem cells was usually very high. There was excellent correlation between in vitro and in vivo drug sensitivity. Both pretreatment drug resistance and selective sensitivity (e.g., interferon, bisantrene, methotrexate, vinblastine) at the time of relapse were accurately detected and correlated well with survival duration (p = 0.01 Wilcoxan). Although LI% and in vitro sensitivity were clearly independent variables, a high LI% (greater than 3%) plus in vitro resistance were associated with a subsequent survival duration of less than 6 mo. The studies allowed dissection of the complex interrelationship between cell kinetics and drug sensitivity.
Hybrid Ultrasound/Magnetic Resonance Simultaneous Acquisition and Image Fusion for Motion Monitoring in the Upper Abdomen

ObjectivesThe combination of ultrasound (US) and magnetic resonance imaging (MRI) may provide a complementary description of the investigated anatomy, together with improved guidance and assessment of image-guided therapies. The aim of the present study was to integrate a clinical setup for simultaneous US and magnetic resonance (MR) acquisition to obtain synchronized monitoring of liver motion. The feasibility of this hybrid imaging and the precision of image fusion were evaluated. Materials and MethodsUltrasound imaging was achieved using a clinical US scanner modified to be MR compatible, whereas MRI was achieved on 1.5- and 3-T clinical scanners. Multimodal registration was performed between a high-resolution T1 3-dimensional (3D) gradient echo (volume interpolated gradient echo) during breath-hold and a simultaneously acquired 2D US image, or equivalent, retrospective registration of US imaging probe in the coordinate frame of MRI. A preliminary phantom study was followed by 4 healthy volunteer acquisitions, performing simultaneous 4D MRI and 2D US harmonic imaging (Fo = 2.2 MHz) under free breathing. ResultsNo characterized radiofrequency mutual interferences were detected under the tested conditions with commonly used MR sequences in clinical routine, during simultaneous US/MRI acquisition. Accurate spatial matching between the 2D US and the corresponding MRI plane was obtained during breath-hold. In situ fused images were delivered. Our 4D MRI sequence permitted the dynamic reconstruction of the intra-abdominal motion and the calculation of high temporal resolution motion field vectors. ConclusionsThis study demonstrates that, truly, simultaneous US/MR dynamic acquisition in the abdomen is achievable using clinical instruments. A potential application is the US/MR hybrid guidance of high-intensity focused US therapy in the liver.
Optimal wire and transistor sizing for circuits with non-tree topology

Conventional methods for optimal sizing of wires and transistors use linear RC circuit models and the Elmore delay as a measure of signal delay. If the RC circuit has a tree topology, the sizing problem reduces to a convex optimization problem which can be solved using geometric programming. The tree topology restriction precludes the use of these methods in several sizing problems of significant importance to high-performance deep submicron design including, for example, circuits with loops of resistors, e.g. clock distribution meshes, and circuits with coupling capacitors, e.g. buses with crosstalk between the lines. The paper proposes a new optimization method which can be used to address these problems. The method uses the dominant time constant as a measure of signal propagation delay in an RC circuit, instead of Elmore delay. Using this measure, sizing of any RC circuit can be cast as a convex optimization problem which can be solved using the recently-developed efficient interior-point methods for semidefinite programming. The method is applied to two important sizing problems-the sizing of clock meshes and the sizing of buses in the presence of crosstalk.
Sidelobe level reduction in microstrip patch antenna array

The reduction in side lobe level (SLL) of a microstrip patch antenna array is discussed. For reducing the surface wave, air core within the substrate below each of the patch antennas is used and to reduce the mutual coupling between the array elements simple narrow strip fence between the elements are used. An array of 16 circular microstrip patch antennas fed through coaxial probes with appropriate Chebyshev amplitude distribution is considered. It is shown that application of the air cores and the narrow strips in the array results in an improvement of the SLL by 4.2 dB and 1.2 dB, respectively. Simulated return loss and pattern results obtained through two software packages of HFSS and CST are provided and results are discussed.