Miracle-dz/UniFAR-FTUs huggingface dataset:
Powerful public sector knowledge management: a school district example

Purpose – Drawn from a recent research study of the Toronto District School Board, this paper aims to examine how the District employs knowledge management to initiate and improve early literacy instruction and achievement.Design/methodology/approach – This study draws on Nonaka and Takeuchi's framework to explore how focusing on tacit‐to‐tacit knowledge‐sharing strategies influence early literacy‐based knowledge sharing within and across schools. Data collection involved the collection and analysis of documents used and designed by Early Years Listeracy Project (EYLP) staff members. The second phase engaged a cross‐section of 34 EYLP teachers, administrators and senior TDSB superintendents and EYLP management team members in individual semi‐structured interviews. Participants commented on their experience vis‐a‐vis the various knowledge management strategies used to support its implementation. Data from the interviews was codified, analyzed and summarized and summaries were shared with participants for c.
Efficacy of liposomal daunorubicin and cytarabine as reinduction chemotherapy in relapsed acute lymphoblastic leukaemia despite expression of multidrug resistance‐related proteins

Abstract: The treatment of relapsed adult acute lymphoblastic leukaemia (ALL) is frequently unsuccessful with current chemotherapy regimens, and often there is an overexpression of multidrug resistance (MDR)‐related proteins. Liposomal encapsulation makes daunorubicin (DNR) less sensitive to the efflux effect of P‐glycoprotein (PGP), and in vitro data indicate that liposomal‐encapsulated DNR (Daunoxome‐DNX) is more toxic than DNR against ALL cell lines. In this study, we assessed the in vivo and in vitro efficacy and toxicity of DNX plus cytarabine (Ara‐C) as reinduction chemotherapy in 25 relapsed ALL patients (pts). The expression of MDR‐related proteins (PGP, MRP1 and LRP) was also analysed. Of the 25 pts, 12 were males and 13 females; median age was 32 yr (range 18–58). Six cases were ALL T and 19 ALL B; eight pts were Ph+ (32%), and nine Bcr‐Abl+ (36%). The expression of MDR‐related proteins, and DNR and DNX retention and induction of apoptosis in leukaemic cells were evaluated in all cases. Seventeen of 25 (68%) pts were at first relapse and eight (32%) at second or subsequent relapse. The DNX was given in a dose of 80 mg/m2/d (days 1–3) in 11/25 pts (44%) and in a dose of 100 mg/m2/d (days 1–3) in 14/25 pts (66%). In all pts, Ara‐C was administered in a dose of 2 g/m2 (days 1–5). Twenty pts (80%) achieved a complete remission (CR) and two (8%) entered a partial remission (PR) for an overall response (OR) rate of 88% (22/25), with a tolerable toxicity and without significant cardiotoxicity. Before the start of DNX therapy, 18/25 (72%) cases overexpressed at least one MDR‐related protein compared with 9/25 (36%) cases with MDR overexpression at diagnosis (P = 0.01). Taking into account the small number of cases, the response rate was not affected by MDR expression and the in vitro results also showed a higher uptake and apoptotic cell death by DNX compared with DNR. Twelve pts subsequently underwent allogeneic bone marrow transplantation (11 unrelated donor BMT, and one sibling BMT). The overall survival was 39% after 12 months. These data show the efficacy (OR rate 88% and CR rate 80%) of DNX plus Ara‐C as reinduction therapy in very poor‐risk ALL pts and the response rate seems not to be affected by MDR overexpression. Moreover, the high rate of remissions and the good clinical tolerance in heavily pretreated pts suggest a promising role of DNX in ALL chemotherapy regimens.
Tiled Microarray Identification of Novel Viral Transcript Structures and Distinct Transcriptional Profiles during Two Modes of Productive Murine Gammaherpesvirus 68 Infection

ABSTRACT We applied a custom tiled microarray to examine murine gammaherpesvirus 68 (MHV68) polyadenylated transcript expression in a time course of de novo infection of fibroblast cells and following phorbol ester-mediated reactivation from a latently infected B cell line. During de novo infection, all open reading frames (ORFs) were transcribed and clustered into four major temporal groups that were overlapping yet distinct from clusters based on the phorbol ester-stimulated B cell reactivation time course. High-density transcript analysis at 2-h intervals during de novo infection mapped gene boundaries with a 20-nucleotide resolution, including a previously undefined ORF73 transcript and the MHV68 ORF63 homolog of Kaposi's sarcoma-associated herpesvirus vNLRP1. ORF6 transcript initiation was mapped by tiled array and confirmed by 5′ rapid amplification of cDNA ends. The ∼1.3-kb region upstream of ORF6 was responsive to lytic infection and MHV68 RTA, identifying a novel RTA-responsive promoter. Transcription in intergenic regions consistent with the previously defined expressed genomic regions was detected during both types of productive infection. We conclude that the MHV68 transcriptome is dynamic and distinct during de novo fibroblast infection and upon phorbol ester-stimulated B cell reactivation, highlighting the need to evaluate further transcript structure and the context-dependent molecular events that govern viral gene expression during chronic infection.
Error detection in digital elevation model using a camera image

A digital elevation model (DEM) contains the elevation of terrain, which is widely used in the geographic information system (GIS). However, a DEM may not be accurate due to the measurement inaccuracy and the change of topography with time. In this paper, we propose a feature based algorithm for detecting DEM elevation errors using a camera image. In the algorithm, we first extract ridges in a depth map obtained from a DEM. We then extract ridges in the corresponding camera image, and determine the elevation error in the DEM, if any, by comparing the corresponding points of ridges between the depth map and camera image. To robustly extract a ridge in the camera image, we adopt a mask that is obtained using the ridge information in the depth map, and apply dynamic programming within the mask. Experimental results show that the proposed algorithm can reliably determine elevation errors in the DEM.
Modelling of hydrogeochemical potential of three lake catchments in Polesie region (Eastern Poland)

Total dissolved solids (TDS) in lake and catchment water is a result of geological structure, as well as duration of rock and water contact and human activity. In this paper, a potential dissolved solids (PtDS) in three Łęczna–Włodawa Lake catchments was determined using extraction and computer software (GIS and AquaChem). Human pressure on water quality was estimated as a difference of the TDS and a catchment hydrogeochemical potential (TPtDS, total potential dissolved solids). TPtDS coefficient included hydrogeological features of the aquifer, soil cover impact on infiltrated water quality, and sediments susceptibility to denudation. The main advantage of the model is a possibility of its employment for every catchment or other areas (e.g. administrative) on both microscale and mesoscale. The highest TPtDS occurred in the catchment, favoured with underground supply, which was located in the vicinity of the Cretaceous mesoregional unit (Chełm Hills). The lowest value was observed in the catchment built with organogenic sediments and coarse material. A seasonal constancy of TPtDS values proved a stability of the lake‐catchment systems under study. Copyright © 2012 John Wiley & Sons, Ltd.
On the outphasing power amplifier nonlinearity analysis and correction using digital predistortion technique

This paper proposes a comprehensive theoretical and experimental analysis of the source of nonlinearity exhibited by outphasing based power amplifiers The important load-pulling effect engendered by the outphasing decomposition and the Chireix combiner is first investigated. Its effect on the two power amplifiers behavior is then identified as the dominant source of nonlinearity in the LINC system. In addition, this paper suggests the application of baseband predistortion technique to mitigate this nonlinear behavior.
Acute Aluminum Toxicity Associated with Oral Citrate and Aluminum‐Containing Antacids

The authors report the development of a rapidly progressive encephalopathy marked by confusion, myoclonus, seizures, coma, and death in a group of women with renal failure who received an oral solution of citrate and aluminum hydroxide gel concurrently. Two patients were documented as having marked hyperaluminemia far exceeding blood aluminum levels encountered in the chronic state of aluminum intoxication. We ascribe the toxicity to enhanced gastrointestinal absorption of aluminum when complexed with citrate.
A Simple Experiment on the Eect of Biasing Sampling Distributions for Planning Reaching Motions with RRTs

This paper reports experiments performed with a simple sampling cache mechanism used to bias the configuration sampling of a RRT-based motion planner. The Planner is used for synthesizing reaching motions for a humanlike character performing object relocation tasks in a virtual environment. Experiments are reported showing that the method can significantly reduce the computational time required for planning arm motions.
Spinal Muscular Atrophy: An Update

Spinal muscular atrophy (SMA) is the most common childhood neurodegenerative disease. We report an infant with SMA type 1 and discuss the recent developments in SMA genetics, pathophysiology, and possible treatment options. Because SMA type 1 remains a fatal illness for which there is not yet a cure, the focus of patient care continues to be symptomatic. Thus, the most appropriate aspects of care at present and future are also discussed.
Novel topologies for finline E- plane filters using split ring resonators

In this paper, an improved technique is outlined to design filters in finline configurations. The new procedure is applied to enhance the performance of filters in planar configuration. For this purpose, split-ring resonators (SRRs) coupled to finline structures are investigated. The new procedure is applied to enhance the performance of filters in planar configuration. This paper illustrates that split ring resonators (SRRs) magnetically coupled to a finline structure can be applied to improve the design of such filters. For this propose, classical variants of millimeter wave filter have been analyzed.
On a capacity equivalence between multiple multicast and multiple unicast

An equivalence between multiple multicast and multiple unicast network coding is proven in a 2007 paper by Dougherty and Zeger. The result is extended to index coding under the assumption of linear coding in recent work by Maleki et al. In this work, we extend the result to arbitrary (e.g. possibly noisy) memoryless networks under an asymptotic definition of reliability. We show the equivalence for non-linear index codes as a special case. Our result implies that solving the multiple unicast communication problem is sufficient to solve all communication problems in memoryless networks.
Acquiring Item Difficulty Estimates: a Collaborative Effort of Data and Judgment. Nominee for Best Paper Award

The evolution from static to dynamic electronic learning environments has stimulated the research on adaptive item sequencing. A prerequisite for adaptive item sequencing, in which the difficulty of the item is constantly matched to the knowledge level of the learner is to have items with a known difficulty level. The difficulty level can be estimated by means of the item response theory (IRT), as often done prior to computerized adaptive testing. However, the requirement of this calibration method is not easily met in many practical learning situations, for instance, due to the cost of prior calibration and due to continuous generation of new learning items. The aim of this paper is to search for alternative estimation methods and to review the accuracy of these methods as compared to IRT-based calibration. Using real data, six estimation methods are compared with IRT-based calibration: proportion correct, learner feedback, expert rating, paired comparison (learner), paired comparison (expert) and the Elo rating system. Results indicate that proportion correct has the strongest relation with IRT-based difficulty estimates, followed by learner feedback, the Elo rating system, expert rating and finally paired comparison.
Catch-up growth and catch-up fat in children born small for gestational age

Infants born small for gestational age (SGA) are at increased risk of perinatal morbidity, persistent short stature, and metabolic alterations in later life. Recent studies have focused on the association between birth weight (BW) and later body composition. Some reports suggest that fetal nutrition, as reflected by BW, may have an inverse programing effect on abdominal adiposity later in life. This inverse association between BW and abdominal adiposity in adults may contribute to insulin resistance. Rapid weight gain during infancy in SGA children seemed to be associated with increased fat mass rather than lean mass. Early catch-up growth after SGA birth rather than SGA itself has been noted as a cardiovascular risk factor in later life. Children who are born SGA also have a predisposition to accumulation of fat mass, particularly intra-abdominal fat. It is not yet clear whether this predisposition is due to low BW itself, rapid postnatal catch-up growth, or a combination of both. In this report, we review the published literature on central fat accumulation and metabolic consequences of being SGA, as well as the currently popular research area of SGA, including growth aspects.
Implications of paleomagnetic data on Miocene extension near a major accommodation zone in the Basin and Range province, northwestern Arizona and southern Nevada

Paleomagnetic data from volcanic and crystalline rocks elucidate the evolution of a major Miocene accommodation zone in the northern Colorado River extensional corridor. The accommodation zone is a 10-km-wide belt of intermeshing conjugate normal faults that facilitates reversals in the dominant tilt direction of fault blocks and dip direction of major normal fault systems. Tilt-corrected means (e.g., N = 28 sites, D = 353.4°, I = 61.3°, α95 = 6.7°, k = 17.4) from Miocene volcanic strata overlap expected Miocene directions at the 95% confidence level. These data and geologic relations suggest that at exposed structural levels the accommodation zone did not facilitate distributed strike-slip displacement between opposing tilt block domains. Vertical axis rotations are probably negligible in most of the corridor, as the Miocene structural grain generally mimics that in the zone. Discrepancies between characteristic remanent magnetizations (ChRM) in crystalline rocks and expected directions are therefore attributed to rotations about horizontal (i.e., tilting or flexing) axes. ChRMs from Cretaceous and Miocene intrusions suggest 50°–90° of tilting of large crystalline terranes on either side of the accommodation zone. The magnitude of tilting inferred from the paleomagnetic data is similar to that of Tertiary strata in nearby fault blocks, implying that these crystalline terranes are parts of highly tilted fault blocks rather than flexed lower plate rocks. Major low-angle normal faults that bound highly tilted parts of these crystalline terranes probably nucleated at steep dips and were rotated to gentle dips by block tilting. Paleomagnetic data indicative of negligible tilting (e.g., Miocene intrusions, northern Black Mountains crystalline terrane, N = 13 sites, D = 359°, I = 55°, α95 = 9°, k = 24) and geologic relations imply that lower plate rocks may surface in both the east and west tilted domains 35–50 km away from the zone. The trend toward shallower structural levels, with respect to Miocene extension, and tapering of highly extended terrane toward the accommodation zone imply that the magnitude of upper crustal extension decreases toward the zone. Temporal patterns of major extension, especially an apparently continuous northward younging across both the east and west tilted domains, further suggest that the accommodation zone served as a long-lived rupture barrier between conjugate normal fault systems rather than as a short-term boundary between opposing systems that propagated toward and converged at the zone.
3D QSAR Pharmacophore Modeling, in Silico Screening, and Density Functional Theory (DFT) Approaches for Identification of Human Chymase Inhibitors

Human chymase is a very important target for the treatment of cardiovascular diseases. Using a series of theoretical methods like pharmacophore modeling, database screening, molecular docking and Density Functional Theory (DFT) calculations, an investigation for identification of novel chymase inhibitors, and to specify the key factors crucial for the binding and interaction between chymase and inhibitors is performed. A highly correlating (r = 0.942) pharmacophore model (Hypo1) with two hydrogen bond acceptors, and three hydrophobic aromatic features is generated. After successfully validating “Hypo1”, it is further applied in database screening. Hit compounds are subjected to various drug-like filtrations and molecular docking studies. Finally, three structurally diverse compounds with high GOLD fitness scores and interactions with key active site amino acids are identified as potent chymase hits. Moreover, DFT study is performed which confirms very clear trends between electronic properties and inhibitory activity (IC50) data thus successfully validating “Hypo1” by DFT method. Therefore, this research exertion can be helpful in the development of new potent hits for chymase. In addition, the combinational use of docking, orbital energies and molecular electrostatic potential analysis is also demonstrated as a good endeavor to gain an insight into the interaction between chymase and inhibitors.
International Journal of Women's Health Dovepress Open Access to Scientific and Medical Research Open Access Full Text Article Dovepress Review of the Safety, Efficacy, Costs and Patient Acceptability of Recombinant Follicle-stimulating Hormone for Injection in Assisting Ovulation Induction in Infer

Anovulation is a common cause of female subfertility. Treatment of anovulation is aimed at induction of ovulation. In women with clomiphene-citrate resistant WHO group II anovulation, one of the treatment options is ovulation induction with exogenous follicle-stimulating hormone (FSH or follitropin). FSH is derived from urine or is produced as recombinant FSH. Two forms of recombinant FSH are available – follitropin alpha and fol-litropin beta. To evaluate the efficacy, safety, costs and acceptability of recombinant FSH, we performed a review to compare recombinant FSH with urinary-derived FSH products. Follitropin alpha, beta and urinary FSH products appeared to be equally effective in terms of pregnancy rates. Patient safety was also found to be comparable, as the incidence of side effects including multiple pregnancies was similar for all FSH products. In practice follitropin alpha and beta may be more convenient to use due to the ease of self-administration, but they are also more expensive than the urinary products.
Porosity and permeability of mesaverde sandstone core from the U. S. DOE multiwell experiment, Garfield County, Colorado

Eight higher permeability Mesa Verde sandstone core samples were selected for determination of the effect of fractional water saturation upon permeability. The dry core samples measured porosity, Klinkenberg permeability, and slope, and pore volume compressiblity and pressure. Measurement of the variation in permeability to gas as functions of net stress and water content revealed a dramatic difference between fluvial samples with high pore volume compressibility and paludal samples with lower pore volume compressibility.
Microfocused Ultrasound with Visualization and Calcium Hydroxylapatite for Improving Skin Laxity and Cellulite Appearance

Background: Age-associated skin laxity contributes to worsening of cellulite appearance. This study evaluated the effects of microfocused ultrasound with visualization (MFU-V; Ultherapy) in combination with diluted calcium hydroxylapatite (CaHA; Radiesse) on cellulite appearance and on neocollagenesis. Methods: Twenty women (18–55 years old) with skin laxity and moderate-to-severe cellulite on the buttocks and thighs were retrospectively enrolled. MFU-V was applied using 4 and 7 MHz transducers (25 lines/transducer/site) and immediately followed by subdermal CaHA injection (1 ml/buttock or thigh). Photographs at baseline and 90 days were assessed by 2 independent, blinded evaluators using a 5-item cellulite severity scale. One subject scheduled for thighplasty received treatment with 6 different CaHA dilutions (0.3 ml/5 cm2) followed by MFU-V. Tissue specimens from each dilution site were examined under polarized light microscopy to assess neocollagenesis. Results: Both evaluators reported statistically significant improvements compared with baseline for each item on the cellulite severity scale (P < 0.001) with a 4.5-point improvement in mean overall score (P < 0.001) after a single MFU-V/CaHA treatment. At 90 days, histologic analysis showed peak neocollagenesis in samples treated with the 1:1 dilution, whether with CaHA alone or in combination with MFU-V. The highest conversion of collagen type III into collagen type I at month 3 occurred in samples injected with 1:1 and 1:0.6 CaHA dilutions without subsequent MFU-V treatment. Both procedures were well tolerated, and subject satisfaction was high. Conclusions: Combination treatment with MFU-V and diluted CaHA is effective for improving skin laxity and the appearance of cellulite on the buttocks and upper thighs.
Pyoverdine-Mediated Regulation of FpvA Synthesis in Pseudomonas aeruginosa: Involvement of a Probable Extracytoplasmic-Function Sigma Factor, FpvI

ABSTRACT A search of the pvd pyoverdine biosynthesis locus of Pseudomonas aeruginosa identified an open reading frame, PA2387, whose product exhibited a sequence similar to those of a number of so-called extracytoplasmic- function sigma factors responsible for siderophore-dependent expression of iron-siderophore receptors in Escherichia coli and Pseudomonas putida. Deletion of this gene, dubbed fpvI, compromised pyoverdine-dependent FpvA ferric pyoverdine receptor production and fpvA gene expression, while the cloned gene stimulated fpvA expression. A Fur-binding site was identified immediately upstream of fpvI, consistent with the observed iron-regulated expression of fpvI and fpvA.