Miracle-dz/UniFAR-FTUs huggingface dataset:
Human Skeletal Remains of the Yayoi Period from the Iwatsubo Cave Site in Gunma Prefecture, Kanto District

群馬県,岩津保洞窟遺跡出土の弥生時代中期前半に属する人骨群について,観察及び計測を行い,同時に縄文人,北部九州弥生人,古墳人,現代和人との比較分析を行なった。 本人骨群は,関東地方内陸部出土の保存良好な弥生時代人骨としては初めてのものである。 比較的完全な熟年女性2体には,頭骨及び体肢骨に縄文人的特徴が強く認められ,両個体とも縄文時代人の直接の子孫であると考えられる。 しかし一方で,両個体とも推定身長が高く,かつ四肢骨が太いという点において,比較に用いた縄文人とは多少異なるようである。
Research on Visual Approach of Selection for Evacuation Route during Flood Disaster Based on ArcEngine

The selection for the evacuation route during flood disaster is of great importance for minimizing the losses and protecting people's life and properties.Taking the flood inundation map of Liao River as the basic data,and ArcEngine 9.2 module as the development tool in Visual Basic,the optimal evacuation route during flood disaster is generated according to the road right analysis model and the road network datasets founded in ArcGis,which provides the flood victims with the accurate evacuation route,so as to retreat quickly.
Structural and mechanistic insights into the CRISPR inhibition of AcrIF7

Abstract The CRISPR–Cas system provides adaptive immunity for bacteria and archaea to combat invading phages and plasmids. Phages evolved anti-CRISPR (Acr) proteins to neutralize the host CRISPR–Cas immune system as a counter-defense mechanism. AcrIF7 in Pseudomonas aeruginosa prophages strongly inhibits the type I-F CRISPR–Cas system. Here, we determined the solution structure of AcrIF7 and identified its target, Cas8f of the Csy complex. AcrIF7 adopts a novel β1β2α1α2β3 fold and interacts with the target DNA binding site of Cas8f. Notably, AcrIF7 competes with AcrIF2 for the same binding interface on Cas8f without common structural motifs. AcrIF7 binding to Cas8f is driven mainly by electrostatic interactions that require position-specific surface charges. Our findings suggest that Acrs of divergent origin may have acquired specificity to a common target through convergent evolution of their surface charge configurations.
Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4

Endolysosomal exonucleases PLD3 and PLD4 (phospholipases D3 and D4) are associated with autoinflammatory and autoimmune diseases. We report structures of these enzymes, and the molecular basis of their catalysis. The structures reveal an intra-chain dimer topology forming a basic active site at the interface. Like other PLD superfamily members, PLD3 and PLD4 carry HxKxxxxD/E motifs and participate in phosphodiester-bond cleavage. The enzymes digest ssDNA and ssRNA in a 5′-to-3′ manner and are blocked by 5′-phosphorylation. We captured structures in apo, intermediate, and product states and revealed a ‘link-and-release’ two-step catalysis. We also unexpectedly demonstrated phosphatase activity via a covalent 3’- phosphistidine intermediate. PLD4 contains an extra hydrophobic clamp that stabilizes substrate and could affect oligonucleotide substrate preference and product release. Biochemical and structural analysis of disease-associated mutants of PLD3/4 demonstrated reduced enzyme activity or thermostability and the possible basis for disease association. Furthermore, these findings provide insight into therapeutic design.
Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase

NADPH oxidases (NOXs) play a major role in the physiology of eukaryotic cells by mediating the production of reactive oxygen species (ROS). Evolutionarily distant proteins sharing the NOX catalytic core have been recently described in Bacteria. Among them, the Streptococcus pneumoniae NOX (SpNOX) has been proposed as a model for the study of NOXs due to its high activity and stability in detergent micelles. Here, we report high-resolution cryo-EM structures of substrate-free and stably reduced NADH-bound SpNOX, and of the NADPH-bound SpNOX and a Phe397Ala mutant under turnover conditions. In combination with structure-guided mutagenesis and biochemical analyses, we provide the structural basis for constitutive activity, the lack of substrate specificity towards NADPH and the electron transfer pathway. Additionally, we shed light on the catalytic regulation by the C-terminal tail residue Phe397 and the potential in vivo function of this protein.
Benchmarking: Performance on ALPS and Formosa Clusters

— This paper presents the benchmarking results and performance evaluation of differentclustersbuilt atthe National Center for High-Performance Computingin Taiwan. Performance of processor, memory subsystem andinterconnect is a critical factor in the overall performance of high performance computing platforms. The evaluation compares different system architecture and software platforms. Most supercomputer used HPL to benchmark their system performance, in accordance with the requirement of the TOP500 List. In this paper we consider system memory access factors that affect benchmark performance, such as processor and memory performance.We hope these works will provide useful information for future development and construct cluster system.
Association of nonalcoholic fatty liver disease with colorectal adenomatous polyps and non-adenomatous polyps: a cross-sectional study

Aim This study aimed to investigate the association between non-alcoholic fatty liver disease (NAFLD) and both colorectal adenomatous polyps and non- adenomatous polyps, in order to provide evidence for the prevention of colorectal cancer (CRC) in patients with NAFLD. Methods A retrospective, cross-sectional study was conducted at the First People’s Hospital of Kunshan, Jiangsu, China. The study included 3028 adults who underwent abdominal ultrasonography and colonoscopy over a 5 year period. We compared characteristics among patients with adenomatous polyps, non-adenomatous polyps, and without colorectal polyps using descriptive statistics. Logistic regression analyses were used to detect associations between NAFLD with the prevalence of adenomatous polyps and non-adenomatous polyps. NAFLD was determined by abdominal ultrasound. Colorectal polyps were assessed by data in the colonoscopy report and pathology report. Results A total of 65% of patients with NAFLD had colorectal polys (52% adenomatous polyps and 13% non-adenomatous polyps), and 40% of patients without NAFLD had polyps (29% adenomatous polyps and 11% non-adenomatous polyps). After adjusting for confounding variables, NAFLD was significantly associated with the prevalence of adenomatous in males and females [odds ratio (OR) = 1.8, 95% confidence interval (CI): 1.6–2.2, P < 0.01], but was not associated with non-adenomatous polyps (OR = 1.2, 95% CI:0.9–1.5, P > 0.05). Conclusion NAFLD is associated with an increased risk of colorectal adenomatous polyps compared to the absence of polyps, but not associated with an increased risk of non-adenomatous polyps. These results provide important evidence for the prevention of CRC in patients with NAFLD.
Integrated Perception System for Mobile Robot and Its Improved Registration

With the integrated perception system of camera and laser ranger,the problems based on feature point matching are researched.Combined with 3D laser ranger and camera working features,referring to the problem of laser ranger mixpixels and edging points,associated scanning sequence filter(ASSF) is designed.The influence of registration feature point extraction from mixpixels is largely decreased,extraction precision is increased,and the registration results of 3D laser ranger and camera are more accurate.Besides,laser ranger coordinate origin position calibration method based on structure feature is proposed,which reduces the measuring error of laser ranger.The research results show that the integrated perception system can accurately perceive mobile robot running environment.
Derived ocean features for dynamic ocean management

Primary environmental variables, such as sea surface temperature, wind speed, and chlorophyll, have been used widely in a variety of studies by biological oceanographers to explore the relationship between "physics" and, say, distribution and abundance of marine organisms. Fisheries scientists in particular have explored a range of relationships between physics and catch data to understand fish distribution and fishing impacts. The explanatory power of models based on such primary variables is typically limited and may not lead to insight into mechanisms behind the environmental associations. Variables that are more direct measures of habitat, such as thermal fronts, upwelling zones, eddies, and water column descriptors (e.g., mixed layer depth), may yield additional explanatory power. We have developed a suite of these derived variables and demonstrate their utility using examples from Australian fisheries and marine spatial planning. Refinement and access to derived variables may be useful in a range of applications, including catch standardization, habitat prediction, ecosystem models, spatial management, and harvest strategies, and will play an important role in the emerging area of dynamic ocean management.
YIELD RESPONSE OF COMMERCIAL CANOLA CULTIVARS TO DIFFERENT LOCATIONS USING GRAPHICAL GGE BIPLOT METHOD

هديكچ هدافتسا اب ازلك رد طيحم و پيتونژ لباقتم رثا شهوژپ نيا رد . تسا هتفرگن تروص ناريا رد ازلك ماقرا دركلمع یرادياپ هنيمز رد یعماج تاعلاطم نونكات رظن زا و تشك جدننس و زاريش ،رمشاك ،دنجريب ،جرك لماش هقطنم جنپ رد ازلك مقر هد . تفرگ رارق یسررب دروم GGE biplot یكيفارگ شور زا لباقتم رثا . دندش تشك 1389-90 یعارز لاس رد راركت هس اب یفداصت لماك یاه كولب حرط بلاق رد یسررب دروم ماقرا . دندش یبايزرا هناد دركلمع ار اه هداد تارييغت زا دصرد 94 عبرم رتم رد هناد دركلمع تفص یارب رظن دروم GGE□biplot رادومن . دوب راد ينعم هناد دركلمع یارب طيحم و پيتونژ یرادياپ زا اندوم مقر زين مقر هس نيا نيب زا . دندوب هناد دركلمع نيرتشيب یاراد اندوم و Hyola308 ،دروكيل ماقرا بيترت هب شور نيا ساسا رب . دومن هيجوت یسررب دروم قطانم هناد دركلمع تفص اب هطبار رد . دوب رادروخرب هناد دركلمع نازيم نيرتمك زا زين Opera مقر ،لباقم رد . دوب رادروخرب یرتشيب دركلمع دروم یاه ناكم . دوب دنجريب لماش موس طيحم ربا و زاريش لماش مود طيحم ربا ،جدننس و رمشاك ،جرك لماش لوا طيحم ربا . دندش ميسقت طيحم ربا هس هب . دندوب دنجريب و زاريش ،جدننس ،رمشاك ،جرك لماش بيترت هب ماقرا زيمت تردق رظن زا رظن
Design thinking: a cognitive resource for improving workforce analytics and training evaluation

Purpose The firms use training evaluation practices (TEPs) to determine the return of billions of dollars spent on employee training and development activities. The firms need to modernize the set of TEPs for evidence-based workforce management decisions. This study aims to examine a mediation mechanism to explain how human resource (HR) professionals’ design thinking (DT) mindset strengthens the set of TEPs using predictive workforce analytics (PWAs). Design/methodology/approach The authors used SPSS computational named MLMED to test the proposed relationships by collecting data from 180 management professionals serving in subsidiaries of multinational corporations in Pakistan. Findings The statistical results demonstrated that DT is not directly related to firms’ TEPs. However, the statistical results supported the mediating role of firms’ use of PWAs between DT and TEPs. Originality/value The findings offer a new perspective for firms to use HR professionals’ DT mindset for modernizing the set of existing HR practices.
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method

Significance We identify several common genetic variants associated with cognitive performance using a two-stage approach: we conduct a genome-wide association study of educational attainment to generate a set of candidates, and then we estimate the association of these variants with cognitive performance. In older Americans, we find that these variants are jointly associated with cognitive health. Bioinformatics analyses implicate a set of genes that is associated with a particular neurotransmitter pathway involved in synaptic plasticity, the main cellular mechanism for learning and memory. In addition to the substantive contribution, this work also serves to show a proxy-phenotype approach to discovering common genetic variants that is likely to be useful for many phenotypes of interest to social scientists (such as personality traits). We identify common genetic variants associated with cognitive performance using a two-stage approach, which we call the proxy-phenotype method. First, we conduct a genome-wide association study of educational attainment in a large sample (n = 106,736), which produces a set of 69 education-associated SNPs. Second, using independent samples (n = 24,189), we measure the association of these education-associated SNPs with cognitive performance. Three SNPs (rs1487441, rs7923609, and rs2721173) are significantly associated with cognitive performance after correction for multiple hypothesis testing. In an independent sample of older Americans (n = 8,652), we also show that a polygenic score derived from the education-associated SNPs is associated with memory and absence of dementia. Convergent evidence from a set of bioinformatics analyses implicates four specific genes (KNCMA1, NRXN1, POU2F3, and SCRT). All of these genes are associated with a particular neurotransmitter pathway involved in synaptic plasticity, the main cellular mechanism for learning and memory.
NEOLIBERALISM AND MEGA-EVENT SECURITY LEGACIES: THE 2010 FIFA WORLD CUP, CAPE TOWN, SOUTH AFRICA

There is a considerable body of literature evaluating legacies of sport mega-events (Cornelissen, 2007; Cornelissen, Bob, & Swart, 2011; Fourie & Santana-Gallego, 2010; Gold & Gold, 2005; Hall, 1998, Preuss, 2007ab). However, with few exceptions (Boyle & Haggerty, 2009; Coaffee, Fussey & Moore, 2011; Giulianotti & Klauser, 2010) there has been little research into what has been described as the ‘security legacies’ of large one-off events. Mega-events that are not permanently based at the same site - ambulatory spectacles that move from country to country - may produce ‘a range of security-related strategies and impacts which continue to have significance beyond the life of the sport event’ (Giulianotti & Klauser, 2010, pp. 53-54). In short, although the mega-event moves from one site to another, a range of legacies - whether planned or unplanned - may remain in the host environment. Legacies include expertise and resources in respect of post-event security. Therefore, this study assesses the impact of the 2010 FIFA World Cup (FWC) in terms of security measures, and their subsequent legacy focussing on particular changes pertaining to security measures: practices (visible policing), technologies (CCTV and equipment) and externally imposed social transformations (removal of the undesired) that result from event hosting.
Geological Block Structures in the Northern Noto Peninsula, through Gravity Anomalies

§ 1. は じ め に 能登半島周辺,特に北方沖から西方沖の海域には,活 断層が存在し,それらの活断層の活動として,1993 年 能登半島沖地震 (M6.6) や 2007 年能登半島地震 (M6.9) が ある. 能登半島では,海岸段丘面の旧汀線高度分布から 第四紀後半以降に活動した地塊構造の存在が提唱されて いる[太田・平川 (1979)]. Hiramatsu et al. (2008) は, 2007 年能登半島地震による海岸隆起の研究から,海底 活断層の運動による地殻変動が地塊構造の形成に大きな 役割を果たしていることを示唆している. また,Honda et al. (2008) は,地塊構造と重力異常分布を比較し, 2007 年能登半島地震による震源断層の拡がりが地塊境 界によって制約されたことを示唆した. このことは,地 下基盤面の深度差を反映する重力異常の情報が地塊構造 の形成と断層運動との関連性を理解する上で重要である ことを意味する. 本研究では,能登半島北部地域において稠密な重力測 定を行い,既往の海域および陸域のブーゲー異常分布図 や重力データと統合することによって,海と陸の両域にわ たる詳細な重力異常分布データを作成した. また,この重 力異常分布に基づき地下の構造境界を推定し,能登半島北 部の重力異常分布と地塊構造との関係について報告する.
On the edge: Evolution of polarity protein BASL and the capacity for stomatal lineage asymmetric divisions

Asymmetric and oriented stem cell divisions enable the continued production of patterned tissues. The molecules that guide these divisions include several “polarity proteins” that are localized to discrete plasma membrane domains, are differentially inherited during asymmetric divisions, and whose scaffolding activities can guide division plane orientation and subsequent cell fates. In the stomatal lineages on the surfaces of plant leaves, asymmetric and oriented divisions create distinct cell types in physiologically optimized patterns. The polarity protein BASL is a major regulator of stomatal lineage division and cell fate asymmetries in Arabidopsis, but its role in the stomatal lineages of other plants is unclear. Here, using phylogenetic and functional assays, we demonstrate that BASL is a eudicot-specific polarity protein. Among dicots, divergence in BASL’s roles may reflect some intrinsic protein differences, but more likely reflects previously unappreciated differences in how asymmetric cell divisions are employed for pattern formation in different species. This multi-species analysis therefore provides insight into the evolution of a unique polarity regulator and into the developmental choices available to cells as they build and pattern tissues. HIGHLIGHTS BASL is a eudicot-specific regulator of stomatal lineage asymmetric cell divisions BASL protein evolution includes stepwise addition of polarity domains to an ancestral MAPK-binding chassis Cellular quiescence and BASL-guided polarity generate proper stomatal spacing in tomato Cell size and fate asymmetries are uncoupled in the tomato stomatal lineage
Neuroeconomics : How neuroscience can inform economics

1 Who knows what I want to do? Who knows what anyone wants to do? How can you be sure about something like that? Isn't it all a question of brain chemistry, signals going back and forth, electrical energy in the cortex? How do you know whether something is really what you want to do or just some kind of nerve impulse in the brain. Some minor little activity takes place somewhere in this unimportant place in one of the brain hemispheres and suddenly I want to go to Montana or I don't want to go to Montana. Introduction When early neoclassical economists built economic theory on a foundation of individual behavior, the psychological model they adopted was an old one. They saw human behavior as the outcome of a process of decision-making, weighing costs and benefits of actions to maximize utility (i.e., happiness, a la Bentham). Economists of this era had doubts about the plausibility of utility maximization. Viner (1925, 373-374) lamented that: Human behavior, in general, and presumably, therefore, also in the market place, is not under the constant and detailed guidance of careful and accurate hedonic calculations, but is the product of an unstable and unrational complex of reflex Economists were also disturbed by the fact that, because utility could not be measured objectively, it could not be used to predict behavior in an independent fashion. So they gave up. As Jevons [, 1871 #3931 commented, I hesitate to say that men will ever have the means of measuring directly the feelings of the human heart. It is from the quantitative effects of the feelings that we must estimate their comparative amounts. Since feelings were meant to predict behavior, but could only be assessed from behavior, economists realized that without direct measurement, feelings were useless intervening constructs. 2 In the 1940s, the concepts of ordinal utility and revealed preference eliminated the superfluous intermediate step of positing immeasurable feelings. Revealed preference theory simply equates unobserved preferences with observed choices. Circularity is avoided by assuming that people behave consistently, which makes the theory falsifiable; once they have revealed that they prefer A to B, people should not subsequently choose B over A. Like behaviorist psychology in the 1920s, which disdained reference to unobservable psychological " mentalist " constructs, ordinal utility and revealed preferences gave economists an easy way to avoid the messy reality of the psychology underlying utility. Later …
Coarse‐grained molecular dynamics simulation of polymers: Structures and dynamics

For the simulations of polymeric systems, coarse‐grained (CG) molecular dynamics simulations are computationally demanding not only because of their high computational efficiency, but also these CG models can provide sufficient structural and dynamical properties at both micro‐ and meso‐scopic levels. During the past decades, developments of these CG models are roughly in two directions, that is, generic and chemically system‐specific models. The developme of the formmer focuses on the capability of the model to capature the general properties of the system, for instance, scaling relations between both structural and dynamic properties with respect to chain length. On the other hand, to bridging the gap between physics and chemistry, chemically‐specifi models are also widely developed which are able to retain the inherent chemical–physical properties for a given polymer system. However, due to the reduction of atomistic degree of freedom a faithful reproduction of structure and especialy dynamics properties of the system is the maijor challenge. In this review, after a brief introduction of some widely used generic models, we present an overview of both recent achievements and remainning challendges in the development of chemically‐specific CG approaches, for the simulations of polymer systems.
Deconvolution enhanced direction of arrival estimation using one- and three-component seismic arrays applied to ocean induced microseisms

Microseisms in the period of 2-10 seconds are generated in deep oceans and near coastal regions. It is common for microseisms from multiple sources to arrive at the same time at a given seismometer. It is therefore desirable to be able to measure multiple slowness vectors accurately. Popular ways to estimate the direction of arrival of ocean induced microseisms are the conventional (fk) or adaptive (Capon) beamformer. These techniques give robust estimates, but are limited in their resolution capabilities and hence do not always detect all arrivals. One of the limiting factors in determining direction of arrival with seismic arrays is the array response, which can strongly influence the estimation of weaker sources. In this work, we aim to improve the resolution for weaker sources and evaluate the performance of two deconvolution algorithms, Richardson-Lucy deconvolution and a new implementation of CLEAN-PSF. The algorithms are tested with 3 arrays of different aperture (ASAR, WRA and NORSAR) using 1 month of real data each and compared with the conventional approaches. We find an improvement over conventional methods from both algorithms and the best performance with CLEAN-PSF. We then extend the CLEAN-PSF framework to 3 components and evaluate 1 year of data from the Pilbara Seismic Array (PSAR) in north-west Australia. The 3 component CLEAN-PSF analysis is capable in resolving a previously undetected Sn phase.