Miracle-dz/UniFAR-FTUs huggingface dataset:
Does prism adaptation affect visual search in spatial neglect patients: A systematic review

Prism adaptation (PA) is a widely used intervention for (visuo-)spatial neglect. PA-induced improvements can be assessed by visual search tasks. It remains unclear which outcome measures are the most sensitive for the effects of PA in neglect. In this review, we aimed to evaluate PA effects on visual search measures. A systematic literature search was completed regarding PA intervention studies focusing on patients with neglect using visual search tasks. Information about study content and effectiveness was extracted. Out of 403 identified studies, 30 met the inclusion criteria. The quality of the studies was evaluated: Rankings were moderate-to-high for 7, and low for 23 studies. As feature search was only performed by five studies, low-to-moderate ranking, we were limited in drawing firm conclusions about the PA effect on feature search. All moderate-to-high-ranking studies investigated cancellation by measuring only omissions or hits. These studies found an overall improvement after PA. Measuring perseverations and total task duration provides more specific information about visual search. The two (low ranking) studies that measured this found an improvement after PA on perseverations and duration (while accuracy improved for one study and remained the same for the other). This review suggests there is an overall effect of PA on visual search, although complex visual search tasks and specific visual search measures are lacking. Suggestions for search measures that give insight in subcomponents of visual search are provided for future studies, such as perseverations, search path intersections, search consistency and using a speed-accuracy trade-off.
The Effects of Environmental, Social and Governance on the Corporate Performance of Malaysian Government-Linked Companies

This study examines the impacts of ESG on the corporate performance government-linked companies (GLCs) in Malaysia. For the period 2006-2012, ESG disclosure data were extracted from the Sustainalytics ESG performance reports, while financial data were obtained from the Bloomberg database. Data development analysis (DEA) was used to estimate efficiency in the first stage; a regression analysis was performed to test the relationship between ESG and efficiency in the second stage. The empirical results of this study show that GLCs focused more on governance disclosures, followed by social and environmental aspects. Moreover, governance will improve firm efficiency, but social and environmental factors have no similar effect. In conclusion, this study provides insight on the limited literature on ESG and informs the relevant stakeholders on the important ESG components for financial and investment decisions.
Genomic profiling of stage II and III colon cancers reveals APC mutations to be associated with survival in stage III colon cancer patients

Tumor profiling of DNA alterations, i.e. gene point mutations, somatic copy number aberrations (CNAs) and structural variants (SVs), improves insight into the molecular pathology of cancer and clinical outcome. Here, associations between genomic aberrations and disease recurrence in stage II and III colon cancers were investigated. A series of 114 stage II and III microsatellite stable colon cancer samples were analyzed by high-resolution array-comparative genomic hybridization (array-CGH) to detect CNAs and CNA-associated chromosomal breakpoints (SVs). For 60 of these samples mutation status of APC, TP53, KRAS, PIK3CA, FBXW7, SMAD4, BRAF and NRAS was determined using targeted massive parallel sequencing. Loss of chromosome 18q12.1-18q12.2 occurred more frequently in tumors that relapsed than in relapse-free tumors (p < 0.001; FDR = 0.13). In total, 267 genes were recurrently affected by SVs (FDR < 0.1). CNAs and SVs were not associated with disease-free survival (DFS). Mutations in APC and TP53 were associated with increased CNAs. APC mutations were associated with poor prognosis in (5-fluorouracil treated) stage III colon cancers (p = 0.005; HR = 4.1), an effect that was further enhanced by mutations in MAPK pathway (KRAS, NRAS, BRAF) genes. We conclude that among multiple genomic alterations in CRC, strongest associations with clinical outcome were observed for common mutations in APC.
A MULTISTATE CAPTURE-RECAPTURE MODEL USING A POSTERIORI CLASSIFICATION TO ENHANCE ESTIMATION OF MOVEMENT RATES

Abstract Biologists commonly use multistate capture-recapture models to estimate movement and survival rates of animals. Recent improvements to genetic and stable-isotope techniques have created the potential for making a posteriori determinations of an animal's location. Here, I present a new multistate model structure that incorporates captured animals' backdated locations. To provide data for this model, I developed a computer simulation in which birds moved between two geographic strata during three time periods. Birds were captured and assigned mortality, and multistate capture histories were recorded. I enhanced capture histories for birds using data from simulated stable-isotope analyses. I then used the modified multistate model to estimate survival, movement, and recapture probabilities. I evaluated the ability of stable-isotope data to more precisely estimate movement over a range of recapture and movement rates. In each of nine simulations, information from stable isotopes improved the precision of the movement estimate; estimates and precision of survival and recapture rates did not change. As real stable-isotope data sets become available, this estimation model may be useful to biologists interested in improving precision of movement rates among geographic strata. Un Modelo Multi-Estado de Captura-Recaptura Usando Clasificación A Posteriori para Potenciar la Estimación de Tasas de Movimiento Resumen. Los biólogos usan generalmente modelos multi-estado de captura-recaptura para estimar las tasas de movimiento y supervivencia de los animales. Las mejoras recientes de las técnicas genéticas y de isótopos estables han creado el potencial de hacer determinaciones a posteriori de la localización de un animal. Aquí presento la estructura de un nuevo modelo multi-estado que incorpora las localidades pasadas de animales capturados. Para contar con datos para este modelo, desarrollé una simulación en computadora en la cual las aves se movieron entre dos estratos geográficos durante tres períodos de tiempo. Las aves fueron capturadas y se les asignó un valor de mortalidad, y se registraron las historias de capturas multi-estado. Potencié el uso de las historias de captura de las aves empleando datos simulados de análisis de isótopos estables. Luego usé el modelo multi-estado modificado para estimar las probabilidades de supervivencia, de movimiento y de recaptura. Evalué la habilidad de los datos de isótopos estables para estimar movimiento de modo más preciso en un rango de tasas de recaptura y movimiento. En cada una de las nueve simulaciones, la información de los isótopos estables mejoró la precisión de la estimación de movimiento; las estimaciones y la precisión de las tasas de supervivencia y recaptura no variaron. A medida que estén disponibles datos reales de isótopos estables, este modelo de estimación puede ser útil para los biólogos interesados en mejorar la precisión de las tasas de movimiento entre estratos geográficos.
Prediction of Chemical Respiratory Sensitizers Using GARD, a Novel In Vitro Assay Based on a Genomic Biomarker Signature

Background Repeated exposure to certain low molecular weight (LMW) chemical compounds may result in development of allergic reactions in the skin or in the respiratory tract. In most cases, a certain LMW compound selectively sensitize the skin, giving rise to allergic contact dermatitis (ACD), or the respiratory tract, giving rise to occupational asthma (OA). To limit occurrence of allergic diseases, efforts are currently being made to develop predictive assays that accurately identify chemicals capable of inducing such reactions. However, while a few promising methods for prediction of skin sensitization have been described, to date no validated method, in vitro or in vivo, exists that is able to accurately classify chemicals as respiratory sensitizers. Results Recently, we presented the in vitro based Genomic Allergen Rapid Detection (GARD) assay as a novel testing strategy for classification of skin sensitizing chemicals based on measurement of a genomic biomarker signature. We have expanded the applicability domain of the GARD assay to classify also respiratory sensitizers by identifying a separate biomarker signature containing 389 differentially regulated genes for respiratory sensitizers in comparison to non-respiratory sensitizers. By using an independent data set in combination with supervised machine learning, we validated the assay, showing that the identified genomic biomarker is able to accurately classify respiratory sensitizers. Conclusions We have identified a genomic biomarker signature for classification of respiratory sensitizers. Combining this newly identified biomarker signature with our previously identified biomarker signature for classification of skin sensitizers, we have developed a novel in vitro testing strategy with a potent ability to predict both skin and respiratory sensitization in the same sample.
Design and development of low-cost exoskeleton hand robot structure

Number of people with traumatic injury related to hand amputation is rising up day by day and it causes them to experience a lot of problems, especially in performing their daily life activities. There are many prosthetic hands that have been developed to assist people to do the activities like a normal person. The feature of the hand robot structure is the main issues to be studied in order to construct a user-friendly and highperformance device. There are various considerations must be taken in order to identify the best type of material of the hand robot structure such as material durability, size, weight and fabrication cost. The objective is to present the static analysis of exoskeleton robotic hand structure for the evaluation on the selected material used such as aluminum and acrylonitrile butadiene styrene (ABS). From this, the effect of the material to the strength of the structure is observed. The 3D drawing and the static analysis of the hand robot structural design are performed by using Autodesk Inventor Professional software. The static analysis is focused on the safety factor evaluation of the structure by referring the ratio between the strength of the finger structure and the force (load) with a direction exerted on the tip of it. Hence, the maximum load withstood by the structure with the respective material can be determined. The results have shown that the maximum force that can be withstood by aluminum hand robot structure is much higher than ABS hand robot structure. The findings have shown that aluminum finger structure is able to withstand less than 3KG of load for no damage on the structure. Thus, the strength of robot structure is effected by the type of the material used and aluminum is more durable than ABS.
Estimation of daytime land surface temperature from space radiometer under thin cirrus cloudy skies

Because of the complex influences of cirrus clouds on the estimation of Land Surface Temperature (LST), the traditional LST retrieval algorithms can only be used for clear-sky conditions and there is no LST when the pixel is identified as clouds by cloud mask algorithm. To retrieve LST under cirrus clouds, a three-channel algorithm what is dependent on cirrus optical depth (COD) and effective radius was proposed. The simulated data showed that the daytime LST could be retrieved using the three-channel algorithm with a root mean square error of less than 3.0 K when COD (at 12 μm) was less than 0.7 and viewing zenith angle was less than 60°. Compared with the results of the traditional clear-sky two-channel LST retrieval algorithm, where the maximum RMSE was 17.8 K, the algorithm proposed in this study could significantly improve the accuracy of the daytime LST retrieved using satellite thermal-infrared data.
To build a bridge between two worlds: Mothers' experiences of professional support at the maternity ward

ABSTRACT We studied the experience of professional support among first-time mothers in relation to a scale measuring professional support in maternity care. We used a qualitative study with both an inductive and deductive approach and interviewed nine mothers. Our findings, both inductive and deductive, suggest that first-time mothers expect professional support in their transition into motherhood, building a bridge between two worlds. The first meeting, acknowledging individual needs, and supporting partner participation were important for good support. Maternity care should be organized with a focus on availability and professional support for mothers and the increased participation of their partners. Our scale of measurement can be useful but needs some development.
HIV-coinfected patients respond worse to direct-acting antiviral-based therapy against chronic hepatitis C in real life than HCV-monoinfected individuals: a prospective cohort study

Objective: HIV/HCV-coinfected patients and hepatitis C virus (HCV) monoinfected subjects are thought to respond equally to direct-acting antiviral (DAA)-based therapy despite the lack of data derived from clinical trials. This study is aimed to evaluate the impact of HIV coinfection on the response to DAA-based treatment against HCV infection in the clinical practice. Patients and Methods: In a prospective multicohort study, patients who initiated DAA-based therapy at the Infectious Disease Units of 33 hospitals throughout Spain were included. The primary efficacy outcome variables were the achievement of sustained virologic response 12 weeks after the scheduled end of therapy date (SVR12). Results: A total of 908 individuals had reached the SVR12 evaluation time-point, 426 (46.9%) were HIV/HCV-coinfected, and 472 (52%) received interferon (IFN)-free therapy. In an intention-to-treat analysis, SVR12 rates in subjects with and without HIV-coinfection were 55.3% (94/170 patients) versus 67.3% (179/266 subjects; p = 0.012) for IFN-based treatment and 86.3% (221/256 subjects) versus 94.9% (205/216 patients, p = 0.002) for IFN-free regimens. Relapse after end-of-treatment response to IFN-free therapy was observed in 3/208 (1.4%) HCV-monoinfected subjects and 10/231 (4.4%) HIV/HCV-coinfected individuals (p = 0.075). In a multivariate analysis adjusted for age, sex, transmission route, body-mass index, HCV genotype, and cirrhosis, the absence of HIV-coinfection (adjusted odds ratio: 3.367; 95% confidence interval: 1.15-9.854; p = 0.027) was independently associated with SVR12 to IFN-free therapy. Conclusions: HIV-coinfection is associated with worse response to DAA-based therapy against HCV infection. In patients receiving IFN-free therapy, this fact seems to be mainly driven by a higher rate of relapses among HIV-coinfected subjects.
Tangible Interfaces: An Analysis of User Experience Using the AR Sandbox Project

The desire to make the human-computer interaction more natural, and the limitation between real and virtual became practically imperceptible, resulted in the development of Tangible Interfaces (TUI). In TUI physical objects are interpreted by the system as digital information. Therefore, users interact with the system through the manipulation of physical objects, the system recognizes the actions and responds through the digital projection. The AR Sandbox is a Tangible Interface application that allows the user to view and shape topographic maps. This work presents a reference for the development of tangible interfaces applications, since TUI applications are recent and there are no specific methodologies to evaluate this type of interface. For this purpose, a partnership was made with the Hydric Engineering course to implement the AR Sandbox for didactic and research purposes, and for this work uses it as tangible interface study material. In this work the interaction with AR Sandbox is evaluated in order to extract guidelines useful for development of TUIs.
Molecular Characterization and Differential Expression of Olfactory Genes in the Antennae of the Black Cutworm Moth Agrotis ipsilon

Insects use their sensitive and selective olfactory system to detect outside chemical odorants, such as female sex pheromones and host plant volatiles. Several groups of olfactory proteins participate in the odorant detection process, including odorant binding proteins (OBPs), chemosensory proteins (CSPs), odorant receptors (ORs), ionotropic receptors (IRs) and sensory neuron membrane proteins (SNMPs). The identification and functional characterization of these olfactory proteins will enhance our knowledge of the molecular basis of insect chemoreception. In this study, we report the identification and differential expression profiles of these olfactory genes in the black cutworm moth Agrotis ipsilon. In total, 33 OBPs, 12 CSPs, 42 ORs, 24 IRs, 2 SNMPs and 1 gustatory receptor (GR) were annotated from the A. ipsilon antennal transcriptomes, and further RT-PCR and RT-qPCR revealed that 22 OBPs, 3 CSPs, 35 ORs, 14 IRs and the 2 SNMPs are uniquely or primarily expressed in the male and female antennae. Furthermore, one OBP (AipsOBP6) and one CSP (AipsCSP2) were exclusively expressed in the female sex pheromone gland. These antennae-enriched OBPs, CSPs, ORs, IRs and SNMPs were suggested to be responsible for pheromone and general odorant detection and thus could be meaningful target genes for us to study their biological functions in vivo and in vitro.
Delayed Topical p38 MAPK Inhibition Attenuates Full-Thickness Burn Wound Inflammatory Signaling

Inflammatory signaling pathways, such as p38 mitogen-activated protein kinase (MAPK) play a central role in host responses to injury. In previous studies by the authors, topical p38 MAPK inhibitors effectively attenuated inflammatory signaling in a partial-thickness scald burn model, when applied to the burn wound immediately after injury. However, clinically relevant full-thickness scald burn wounds may act as a barrier to topical immune modulators, and delayed application of topical p38 MAPK inhibitors may not be effective. In this study, the authors evaluate the efficacy of topical p38 MAPK inhibition on full-thickness scald burns with immediate and delayed treatment. C57/BL6 mice received “Sham” or 30% TBSA full-thickness scald burn injury. After injury, the burn wounds were treated with a topical p38 MAPK inhibitor or vehicle. The treatment group received topical p38 MAPK inhibitor either immediately after burn or 4 hours (delayed) after injury. All animals were killed at 12 or 24 hours. Burn wounds underwent histological analyses. Skin and plasma were analyzed by enzyme-linked immunosorbent assay or real-time quantitative polymerase chain reaction for cytokine expression. Full-thickness scald burns resulted from immersion in 62°C water for 25 seconds. Topical p38 MAPK inhibitor attenuated dermal interleukin (IL)-6, MIP-2, and IL-1&bgr; expression and plasma IL-6 and MIP-2 cytokine expression. In addition, delayed application of topical p38 MAPK inhibitors significantly reduced dermal and plasma cytokine expression compared with vehicle control. Topical p38 MAPK inhibitors remain potent in reducing full-thickness burn wound inflammatory signaling, even when treatment is delayed by several hours postinjury. Topical application of p38 MAPK inhibitor may be a clinically viable treatment after burn injury.
Direct binding of Toll-like receptor 4 to ionotropic glutamate receptor N-methyl-D-aspartate subunit 1 induced by lipopolysaccharide in microglial cells N9 and EOC 20

Microglia, the primary immune cells in the brain, are the predominant cells regulating inflammation-mediated neuronal damage. In response to immunological challenges, such as lipopolysaccharide (LPS), microglia are activated and the inflammatory process is subsequently initiated. The aim of the present study was to determine whether LPS induces interactions between the Toll-like receptor 4 (TLR4) and the ionotropic glutamate receptor N-methyl-D-aspartate subunit 1 (GluN1) in N9 and EOC 20 microglial cells. Immunocytochemistry demonstrated co-localization of TLR4 and GluN1 in response to LPS, and the direct binding of TLR4 and GluN1 was further validated by antibody-based Fluorescence Resonance Energy Transfer technology. Inhibition of the group I metabotropic glutamate receptor 5 with its selective antagonist, MTEP, abolished LPS-induced direct binding of TLR4 to GluN1. Therefore, these data demonstrated that GluN1 and TLR4 act reciprocally in response to LPS in N9 and EOC 20 microglial cells.
Proximate and mineral composition of mung bean

Two local varieties, M1 and NM-92 , of mung bean were analyzed for their proximate an d mineral composition using standard methods. In the proximate composition, the moisture , ash, protein, fat, fiber and carbohydrate content s of M1 were found to be 9.4%, 3.9%, 23.7%, 1.9%, 6.8% and 54.9%, respectively while in NM-92 this composition was found to be 8.3%, 3.0%, 20.8%, 2.2%, 7.1% and 58.9%, respectively. The data reveal ed that M1 had relatively higher values of moisture , ash and protein while NM-92 was found to be a bit superior in fat, fiber and carbohydrates content. The food energy value of M1 (340 kcal/100g) and NM-92 (347 kcal/100g) was almost equal. The results of mineral analysis showed that M1 contained relat ively higher content of Na (22 mg/100g), K (1443 mg/100g), Ca (216 mg/100g), Mg (204 mg/100g), P (374 mg/100g), Fe (11.34 mg/100g), Zn (1.88 mg/100g) as compared to NM-92. However, NM-92 was rich in Cu (1.92 mg/100g), Mn (1.49 mg/100g) and Pb (2.64 mg/100g) in comparison to M1. It was also observed that the results of this study were in good comparison with the findings of other researchers. It was concluded that both varieties c ould play a significant nutritional role in human h ealth.
Sagittal Ankle and Midfoot Range of Motion Before and After Revision Total Ankle Replacement: A Retrospective Comparative Analysis

ABSTRACT The most common reason for a revision total ankle replacement procedure is a painful, stiff ankle even after the initial surgery. Limited and conflicting data are available regarding the change in sagittal foot and ankle range of motion after revision total ankle replacement surgery. We sought to determine whether revision total ankle replacements would reduce compensatory midfoot range of motion. In determining this, a novel radiographic measurement system with stable osseous landmarks is used. A retrospective medical record review of patients who had undergone revision total ankle replacement from January 2009 to June 2016 was performed. Thirty‐three patients (33 ankles) underwent revision total ankle replacement surgery and met the inclusion criteria with a mean follow‐up period of 28.39 ± 14.68 (range 2 to 59) months. Investigation of preoperative and postoperative weightbearing lateral radiographic images was performed to determine the global foot and ankle, isolated ankle, and isolated midfoot sagittal ranges of motion. Statistical analysis revealed a significant increase in ankle range of motion (p = .046) and a significant decrease in midfoot range of motion (p < .001) from preoperatively to postoperatively. The change in global foot and ankle range of motion was not significant (p = .53). For this patient population, the increased ankle range of motion effectively resulted in less compensatory midfoot range of motion. Level of Clinical Evidence: 3