Miracle-dz/UniFAR-FTUs huggingface dataset:
A factor VIIIa – mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice

Hemophilia A is a bleeding disorder resulting from de ﬁ cient factor VIII (FVIII), which normally functions as a cofactor to activated factor IX (FIXa) that facilitates activation of factor X (FX). To mimic this property in a bispeci ﬁ c antibody format, a screening was conducted to identify functional pairs of anti-FIXa and anti-FX antibodies, followed by optimization of functional and biophysical properties. The resulting bispeci ﬁ c antibody (Mim8) assembled ef ﬁ ciently with FIXa and FX on membranes, and supported activation with an apparent equilibrium dissociation constant of 16 nM. Binding af ﬁ nity with FIXa and FX in solution was much lower, with equilibrium dissociation constant values for FIXa and FX of 2.3 and 1.5 m M, respectively. In addition, the activity of
Contrasts in composition and evolution of Tertiary CFBs between West and East Greenland and their relations to the establishment of the Icelandic mantle plume

Abstract In the West Greenland CFB Province, the early lava compositions were dominated by tholeiitic picrites more depleted in terms of isotopic and trace element characteristics than CFBs from any other province, and comparable to those of present-day Icelandic lavas. Later basalts have similar isotopic and incompatible element ratios. Generally, the West Greenland CFBs show no significant interaction with the lithosphere. In East Greenland, the early picrites and basalts from the Kangerlussuaq area have a very wide range of compositions, which strongly indicate lithospheric interaction. The Scoresby Sund basalts, as well as later basalts in the Kangerlussuaq area, have much less variable compositions, and are similar to the most enriched modern Icelandic picrites. The difference between the early West and East Greenland volcanic rocks is probably related to differences in tectonic setting. In West Greenland continental rifting started before volcanism on the continental margin. The arrival of the proto-Icelandic plume material made primitive picritic magma rise quickly through the already rifted lithosphere. In East Greenland no rifting took place until c. 4 Ma after the arrival of plume material under West Greenland. This allowed small amounts of plume-derived melts to enter and react with the lithosphere and subsequently be incorporated into the CFB magmas at the rifting stage. No thermal doming took place in East Greenland before or during continental break-up, and the East Greenland rifting is considered to have been passive. Very high temperatures and high degrees of melting during picrite generation in East Greenland is a strong indication that the plume was centred under Kangerlugssuaq at the time of rifting. The vigorous interaction between early magmas and lithosphere makes it likely that the plume was centred here also for the 4 Ma prior to rifting.
Sentinel-1 ESA's new European SAR mission

The ESA Sentinels constitute the first series of operational satellites responding to the Earth Observation needs of the EU-ESA Global Monitoring for Environment and Security (GMES) program. The GMES space component relies on existing and planned space assets as well as on new complementary developments by ESA. This paper describes the Sentinel-1 mission, an imaging synthetic aperture radar (SAR) satellite constellation at C-band. It provides an overview of the mission requirements, its applications and the preliminary technical concept for the system.
Teleconnection Patterns Appearing in the Streamfunction Field

Teleconnection patterns in boreal winter were sought by using the streamfunction based on one-point covariance analysis. As a result, five patterns with two new patterns, i.e., the North and South Pacific Oscillation pattern (PO) and the Middle Atlantic pat tern (MA), were obtained. The PO is an interhemispheric pattern with major centers in the Pacific, related to the El Niño/La Niña. The MA has a similar structure with the East Atlantic pattern (EA), though the orientation of the pattern and the difference in the sus-taining mechanism, as well as a relatively low correlation between the two indices, distinguish the MA from the EA, with the primary importance of the MA from several pieces of evidence. The PO and MA have significant relations to the surface air temperature mostly through the temperature advection. By comparing the result of the combined EOF for the zonal and meridional winds, the appropriateness of the use of the streamfunction in association with wind variations was also confirmed.
An investigation of ionospheric responses, and disturbance thermospheric winds, during magnetic storms over South American sector

[1] This paper presents the results of a study of the ionospheric and thermospheric response to magnetic storm disturbances for four stations covering a wide range of latitude in the South American region. The study is based on the F layer critical frequency (foF2) and the peak height (hmF2) from Fortaleza (FZ), which is equatorial, Cachoeira Paulista (CP), which is low latitude, Concepcion (CON), a midlatitude site, and King George Island (KGI), a middle to high latitude site. Equivalent neutral winds are extracted from the measured hmF2 by employing the Field Line Interhemispheric Plasma (FLIP) model. The Equatorial Ionization Anomaly (EIA) can undergo enhancement due to magnetospheric disturbance electric field that penetrates to low latitudes during the growth phase of a storm/substorm, whereas EIA inhibition occurs more often under disturbance dynamo (DD) electric field. Season-dependent meridional/transequatorial winds can significantly alter the EIA response to disturbance electric fields. Large amplitudes of DD electric field is observed during evening and morning hours in equinoctial, but not in winter, months. Over the Brazilian low latitude of large westward magnetic declination angle, large equatorward meridional wind surges seem to be helped by the presence of disturbance zonal (westward) winds. The low latitude disturbance can, in some cases, be traced to specific disturbance fronts originating promptly from auroral activity enhancements. This study confirms earlier studies that show that the quiet time meridional wind increases with increase of latitude and that over midlatitude it shows decreases with increase of solar flux due to the effect of the ion drag force. This study further shows that the disturbance meridional wind and the intensity of DD electric field increase with increasing intensity of high latitude energy input. The negative ionospheric storm phase over middle latitude, observed in equinox and not in winter, is also intensified with the increasing intensity of high latitude energy input.
A proximity biotinylation map of a human cell

Compartmentalization is an essential characteristic of eukaryotic cells, ensuring that cellular processes are partitioned to defined subcellular locations. High throughput microscopy1 and biochemical fractionation coupled with mass spectrometry2-6 have helped to define the proteomes of multiple organelles and macromolecular structures. However, many compartments have remained refractory to such methods, partly due to lysis and purification artefacts and poor subcompartment resolution. Recently developed proximity-dependent biotinylation approaches such as BioID and APEX provide an alternative avenue for defining the composition of cellular compartments in living cells (e.g. 7-10). Here we report an extensive BioID-based proximity map of a human cell, comprising 192 markers from 32 different compartments that identifies 35,902 unique high confidence proximity interactions and localizes 4,145 proteins expressed in HEK293 cells. The recall of our localization predictions is on par with or better than previous large-scale mass spectrometry and microscopy approaches, but with higher localization specificity. In addition to assigning compartment and subcompartment localization for many previously unlocalized proteins, our data contain fine-grained localization information that, for example, allowed us to identify proteins with novel roles in mitochondrial dynamics. As a community resource, we have created humancellmap.org, a website that allows exploration of our data in detail, and aids with the analysis of BioID experiments.
DEVELOPMENT OF ANALYSIS METHODS USING RECENT DATA

This report documents the second phase of a two-phase project under Strategic Highway Research Program 2 (SHRP 2) Safety Project S01A. The primary objective of this work was to establish an analytic foundation for using conflicts and near crashes as surrogate measures. The project introduced a counterfactual analytic approach suggesting that a traffic event qualifies as a crash cause under two conditions: (a) both the event and the crash occurred and (b) had the event in question not occurred, then the crash also would not have occurred. Data from site-based field studies and vehicle studies were used to extend these ideas from a trajectory model to more complicated scenarios. The report introduces an approach to microscopic (i.e., individual event) modeling of crash-related events, where driver actions, initial speeds, and vehicle locations are treated as inputs to a physical model describing vehicle motion. This choice of modeling strategy reflects a need for such models if realistic crash processes are to be included in microscopic traffic simulation models. The simple trajectory model can be used to estimate features of crash and near-crash events—such as driver reaction times, following headways, and deceleration rates—from trajectory data produced from a site-based field study. Given sufficiently large samples of crash and near-crash events, this method can be used to compile distributions for these inputs for use in traffic simulation models. Finally, the report illustrates how a trajectory model, together with estimates of input variables, can quantify the degree to which a non-crash event could have been a crash event. The report describes how these ideas were extended to more complicated scenarios by using data from both vehicle- and site-based field studies, including data obtained from the 100-car vehicle-based field study, data from site-based video on Interstate 94 from the Minnesota Traffic Observatory, and site-based radar data from the Cooperative Intersection Collision Avoidance System (CICAS) intersection in North Carolina.
List of Reviewer

The Web as a source of information has many potentials which allow to use the different treatments on social network extraction methods. The approaches generally we identified as superficial methods in unsupervised stream. However, the same resources of social networks, i.e. based on a community of social actors, reveal many of different approaches to produce social networks. Therefore, based on a treatment to another treatments, from the given treatments until the different social networks generated and it has been declared different methods. It requires comparison to reveal the properties of social networks and their methods in this paper. It is revealed that there is a core social network has similarity with other social networks is more than 1% as general property of the extracted social networks, whereby there is a social network for different methods has the common edges in graph. c © 2018 The Authors. Published by Elsevier B.V. Peer-review under responsibility of the scientific committee of the 4th Information Systems International Conference 2017.
Crustal structure of the central Costa Rica subduction zone: implications for basal erosion from seismic wide-angle data

On the Pacific margin off central Costa Rica, an anomalous lens-shaped zone is located between the overriding plate and the subducting oceanic lithosphere approximately 25 km landward of the deformation front. This feature was previously recognized in reflection seismic data when it was termed 'megalens'. Its origin and seismic velocity structure, however, could not unambiguously be derived from earlier studies. Therefore during RV SONNE cruise SO163, seismic wide-angle data were acquired in 2002 using closely spaced ocean bottom hydrophones and seismometers along two parallel strike and two parallel dip lines above the 'megalens', intersecting on the middle slope. The P-wave velocities and structure of the subducting oceanic Cocos Plate and overriding Caribbean Plate were determined by modelling the wide-angle seismic data in combination with the analysis of coincident reflection seismic data and the use of synthetic seismograms. The margin wedge is defined by high seismic velocities (4.3-6.1 km s(-1)) identified within a wedge-shaped body covered by a slope sediment drape. It is divided into two layers with different velocity gradients. The lower margin wedge is clearly constrained by decreasing velocities trenchward and terminates beneath the middle slope at the location of the 'megalens'. Seismic velocities of the 'megalens' are lower (3.8-4.3 km s(-1)) relative to the margin wedge. We propose that the 'megalens' represents hybrid material composed of subducted sediment and eroded fragments from the base of the upper plate. Upward-migrating overpressured fluids weaken the base of the margin wedge through hydrofracturing, thus causing material transfer from the upper plate to the lower plate. Results from amplitude modelling support that the 'megalens' observed off central Costa Rica is bound by a low-velocity zone documenting fluid drainage from the plate boundary to the upper plate.
The molecular basis of endolytic activity of a multidomain alginate lyase from Defluviitalea phaphyphila , a representative of a new lyase family, PLxx #

Alginate is a polymer containing two uronic acid epimers, (cid:533)- D -mannuronate (M) and (cid:302)- L -guluronate (G), and is a major component of brown seaweed that is depolymerized by alginate lyases. These enzymes have diverse specificity, cleaving the chain with endo- or exotype activity and with differential selectivity for in the catalytic site. The biochemical and structural analyses of the for this new class of endotype alginate lyases, has our understanding of the structure-function and evolutionary relationships within this important class of enzymes.
Improved Titer and Gene Transfer by Lentiviral Vectors Using Novel, Small -Globin Locus Control Region Elements

1Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA; 2Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA; 3Department of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA; 4CSUN-UCLA Stem Cell Scientist Training Program, California State University, Northridge, Northridge, CA 91330, USA; 5Department of Pediatrics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA; 6The Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research, University of California, Los Angeles, Los Angeles, CA, USA
Notice of RetractionThe relationship between demographic characteristics of entrepreneurs and CSP

The depth of research on the relationship between corporate social performance (CSP) and corporate financial performance (CFP) is significant. However, previous research has not paid adequate attention to the antecedents of CSP. In this paper, we examine the relationship between the demographic characteristics of entrepreneurs and corporate social performance based the upper echelons theory. Using a sample of listed companies of manufacturing in China, our findings indicate that entrepreneurs with output functions experience are connected with higher CSP. In addition, entrepreneurs with shorter tenure are more likely to perform higher CSP.
Implications of seismic waveforms: Complex physical properties associated with stagnant slab

Anomalously broadened P waveforms of deep focus events were observed at some regional stations after sampling flattened high velocity zones. The source processes of these events are short and the P waveforms at other stations as well as the corresponding SH waves do not show such anomaly. The rays of the anomalous waves propagated in the vicinity of those whose waveforms can be synthesized with a relatively simple model M3.11 or M2.0 for a flattened cold slab in the transition zone. We suggest that the P waveform broadening is caused by SV converted waves at the heterogeneities within a narrow zone near the “660 km” discontinuity or slab boundary. The creation of such heterogeneities may involve in the complex structure of phase transformation with water and cold temperature anomaly associated with stagnant slab.
Study of the mechanism that increases the hardness of groundwater: A case study from Beijing urban area

The rapid development of construction and the increase of population water demand were increased rapidly in Beijing, China’s capital city, yet one of its fastest-growing municipalities is running out of water. Today, more than 70% of the municipality’s total water supply comes from groundwater. Therefore groundwater has been over-exploited a long time which led to regional water level down and more and more groundwater is becoming polluted, which has disadvantage on drinking water. As a consequence of a series of physico-chemical and biochemical reactions, including dissolution, ion-exchange and reactions involving organic compounds, the calcium and magnesium in the infiltrating solutions have increased. The solutions have infiltrated into aquifers and increased the hardness of the groundwater; over-abstraction of groundwater has accelerated the process.The ISD = f (ISC) diagram indicates that central part of Beijing's groundwater is relatively recent with a speed of mean circulation. Key words: Development, water demand, pollution, groundwater, hardness, nitrate.
Marketing in turbulent times.

During the past decade, irrational exuberance has turned into a possibly equally irrational pessimism about what the Internet can accomplish. The fear of getting ruined through cannibalization losses has recently deterred many firms from deploying the Internet as a distribution channel. But do Internet channels really cannibalize firms entrenched channels, or is this widely held assumption exaggerated? To answer this question, we apply recent structural-break time-series econometrics to quantify the impact of an Internet channel addition on the long-run performance evolution of a firms established channels. Using a database of 85 Internet channel additions over the last ten years in the newspaper industries of the U.K. and the Netherlands, we find that the often-cited cannibalization fears have, at least in this information-goods industry, been largely overstated. The Internet therefore need not be disruptive to established companies and channels. This does, however, not imply that firms enjoy free play in setting up Internet channels. In cases where the newly established Internet channel too closely mimics the entrenched channels, substantial cannibalization is more likely to take place.
Erosion rates in the source region of an ancient sediment routing system: comparison of depositional volumes with thermochronometric estimates

Calculation of the total depositional volume of an ancient source-to-sink system, combined with estimates of the area of catchments acting as source regions using provenance methods, is used to evaluate average catchment erosion rates on a million year time scale. These rates are compared with values derived from thermochronological methods. Using the mid- to late Eocene (33.9–41.6 Ma) Escanilla palaeo-sediment routing system from the south–central Pyrenean orogenic wedge-top zone as an example, c. 3500 ± 300 km3 of solid particulate sediment was derived from two catchments in the south–central Pyrenees over a 7.7 myr period, equivalent to a mean erosion rate of c. 0.15–0.18 mm a−1. Average exhumation rates in contributing catchments over the same time interval are estimated at 0.2–0.3 mm a−1 based on apatite fission-track analysis of pebbles in proximal conglomerates, and 0.23–0.34 mm a−1 from fission-track analysis of detrital apatites sampling a wider range of grain size. Sediment supply progressively increased during the mid- to late Eocene time period, at least in part driven by catchment expansion deep into the Pyrenean Axial Zone at c. 39 Ma. The consistency of the rates of catchment-averaged erosion calculated from different methods builds confidence that source areas have been connected to depositional sinks correctly. Supplementary materials: A description of the provenance methods used to link sources and sinks of the Escanilla palaeo-sediment routing system, including the analysis of clast lithologies, palaeocurrents, heavy minerals and geochronology of detrital zircons, are available at http://www.geolsoc. org.uk/SUP18727.
Raman Signal Enhancement by Quasi-Fractal Geometries of Gold Nanoparticles

The synthesis of star-like gold nanoparticles (SGNs) in a temperature-controlled environment allows for temperature modulation and facilitates the growth of highly branched nanoparticles. By increasing the synthesis temperature, the level of branching increases as well. These highly branched features represent a distinctly novel, quasi-fractal nanoparticle morphology, referred to herein as gold nano caltrops (GNC). The increased surface roughness, local curvature and degree of inhomogeneity of GNC lend themselves to generating improved enhancement of the scattering signals in surface-enhanced Raman spectroscopy (SERS) via a mechanism in which the localized surface plasmon sites, or “hot spots,” provide the engine for the signal amplification, rather than the more conventional surface plasmon. Here, the synthesis procedure and the surface-enhancing capabilities of GNC are described and discussed in comparison with SGN. Abstract The synthesis of star-like gold nanoparticles (SGNs) in a temperature-controlled environment allows for temperature modulation and facilitates the growth of highly branched nanoparticles. By increasing the synthesis temperature, the level of branching increases as well. These highly branched features represent a distinctly novel, quasi-fractal nanoparticle morphology, referred to herein as gold nano caltrops (GNC). The increased surface roughness, local curvature and degree of inhomogeneity of GNC lend themselves to generating improved enhancement of the scattering signals in surface-enhanced Raman spectroscopy (SERS) via a mechanism in which the localized surface plasmon sites, or “hot spots,” provide the engine for the signal amplification, rather than the more conventional surface plasmon. Here, the synthesis procedure and the surface-enhancing capabilities of GNC are described and discussed in comparison with SGN.