Miracle-dz/UniFAR-FTUs huggingface dataset:
The factors associated with medication errors in adult medical and surgical inpatients: a direct observation approach with medication record reviews.

INTRODUCTION Observing real situations in clinical practice can provide undetected information regarding problems in the medication process. AIMS The aims of this study were to describe the frequency, types, and severity of medication errors in medical and surgical inpatients as well as to study the relationship between medication errors and associating factors. METHODS A cross-sectional study using direct observations and medication record reviews was conducted to assess how 32 registered nurses administered 1058 medications to 122 inpatients in four medical and surgical wards at a university hospital in Finland between April and May 2012. Observations were recorded using a structured observation form and patients' medication record reviews (n = 122) before and after the observations were conducted. A multiprofessional team analysed and classified all of the detected errors and assessed their severity. A logistic regression was used to analyse the factors (work environment, team, person-specific, patient-specific or medication-related) associated with medication errors. RESULTS At least one error was found in 22.2% (235/1058) of administered medications, 63.4% of which were medication administration errors and 18.3% of which were documentation errors. Of the medication administration errors, 59.1% involved an incorrect administration technique. 3.4% of errors caused harm to patients. Statistically significant factors that increased the risk of medication errors included every other weekday, except Sunday; morning shifts; increased rushes; nurses asking for help; and increased number of medications that patients used. Factors that decreased the risk of errors included administering medications through an oral route, double-checking the drugs, and additional people in the medication room at the same time. CONCLUSION Medication errors in inpatient care are frequent, and improvements to increase safety are vital. More attention to medication administration techniques, administration instructions and attitudes toward safety are needed to prevent problems.
Screening and clustering of sparse regressions with finite non‐Gaussian mixtures

This article proposes a method to address the problem that can arise when covariates in a regression setting are not Gaussian, which may give rise to approximately mixture‐distributed errors, or when a true mixture of regressions produced the data. The method begins with non‐Gaussian mixture‐based marginal variable screening, followed by fitting a full but relatively smaller mixture regression model to the selected data with help of a new penalization scheme. Under certain regularity conditions, the new screening procedure is shown to possess a sure screening property even when the population is heterogeneous. We further prove that there exists an elbow point in the associated scree plot which results in a consistent estimator of the set of active covariates in the model. By simulations, we demonstrate that the new procedure can substantially improve the performance of the existing procedures in the content of variable screening and data clustering. By applying the proposed procedure to motif data analysis in molecular biology, we demonstrate that the new method holds promise in practice.
Pattern of Nitrergic Neuronal System Organization in the Brain of Two Holostean Fishes (Actinopterygii: Ginglymodi)

The study of the nitrergic system, formed by the networks of neurons containing the enzyme nitric oxide synthase (NOS), has been extremely useful in unraveling neuroanatomical features of the organization of the central nervous system of vertebrates. Thus, data are available for representatives of most vertebrate classes and, in particular, several studies have detailed the organization of this system in teleosts. In contrast, no information is available regarding this neurotransmission system in the brains of holosteans, an early diverged and poorly understood group of actinopterygian fishes, currently considered a sister group of teleosts that contains only 8 species. The present study provides the first detailed information on the distribution of nitrergic cell bodies and fibers in 2 holostean species of the genus Lepisosteus, the spotted gar L. oculatus and the Florida gar L. platyrhincus. NOS immunohistochemistry and the NADPH diaphorase (NADPH-d) histochemical reaction were used, and both techniques yielded identical results, with the exception of the primary olfactory and terminal nerve fibers, which only labeled for NADPH-d exclusively in L. oculatus. Double immunohistochemistry was conducted for the simultaneous detection of NOS with tyrosine hydroxylase, choline acetyltransferase, calbindin, calretinin, and serotonin to accurately establish the localization of the nitrergic neurons and fibers in the brain of holosteans, the neuroanatomy of which has been mostly neglected, and to assess possible interactions between these neuroactive substances. Distinct groups of nitrergic cells were located in subpallial areas, the basal hypothalamus, posterior tubercle, optic tectum and mesencephalic tegmentum, reticular formation, solitary tract nucleus, spinal cord, and amacrine cells in the retina. In addition, low numbers of nitrergic cells were observed in the pallium, suprachiasmatic nucleus, prethalamic and thalamic areas, torus lateralis and torus semicircularis, cerebellar and laterodorsal tegmental nuclei, and the ventral octavolateral area. Comparison of these results with those from other classes of vertebrates, and including a segmental analysis to correlate cell populations, reveals that the pattern of the nitrergic system in holosteans is very close to that in ancestral actinopterygian fishes and highlights conserved and derived traits.
Automated Closed-System Expansion of Pluripotent Stem Cell Aggregates in a Rocking-Motion Bioreactor

Pluripotent stem cell suspension aggregates have proven to be an efficient and phenotypically stable means for expansion and directed differentiation. Bioreactor systems with automation of perfusion, fluidization, and gas exchange are essential for scaling up pluripotent stem cell cultures. Since stem cell pluripotency and differentiation are affected by both chemical and physical signals, we investigated a low-shear method for the expansion of cells in a rocking-motion bioreactor. The rocking motion drives continual mixing and aeration, and the single-use disposable bioreactors avoid issues around contamination during seeding, medium exchange, passage, and cell harvest. Serial passaging from a 150 mL to a 1 L scale was demonstrated, achieving cell densities of up to 4 million cells/mL. In an average of 13 experiments, pluripotent stem cell aggregates expanded 5.7-fold (with maximal 9.5-fold expansion) and maintained 97% viability over 4 days in a rocking bioreactor culture. In seven experiments with improved culture conditions, the average expansion was 6.8-fold. Maintenance of pluripotency was confirmed by differentiation to all three germ layers and surface marker expression, and the expanded aggregates maintained a stable normal karyotype. The automation associated with the rocking platform bioreactor required no user intervention during the 4-day culture, providing hands-off expansion of pluripotent stem cells.
Nanosuspension Technology for Drug Delivery

The poor water solubility of drugs is major problem for drug formulation. To date, nanoscale systems for drug delivery have gained much interest as a way to improve the solubility problems. The reduction of drug particles into the sub-micron range leads to a significant increase in the dissolution rate and therefore enhances bioavailability. Nanosuspensions are promising candidates that can be used for enhancing the dissolution of poorly water soluble drugs. Nanosuspensions contain submicron colloidal dispersion of pharmaceutical active ingredient particles in a liquid phase stabilized by surfactants. Production of drugs as nanosuspensions has been developed for drug delivery systems as an oral formulation and non-oral administration. This review describes the methods of pharmaceutical nanosuspension production, formulations and pharmaceutical applications in drug delivery as well as the marketed products.
Well‐leg compartment syndrome after laparoscopic low anterior resection for lower rectal cancer in the lithotomy position: A case report

A 64‐year‐old man underwent laparoscopic low anterior resection for lower rectal cancer. Because he was overweight (BMI, 28.1 kg/m2) with rich visceral fat and a narrow pelvic cavity, the operation was technically difficult and the operation time was 686 min. Postoperatively, the patient immediately complained of pain and swelling of the left lower limb. Laboratory examination showed that serum creatinine kinase was markedly increased and urine myoglobin was positive on postoperative day 1. He was diagnosed with well‐leg compartment syndrome and was transported to the trauma and critical care center for emergency fasciotomy. After initial treatment, he was transferred to our hospital on postoperative day 7. He completely recovered after 2 months. Although well‐leg compartment syndrome is rare, it is necessary to consider it as a potential complication when performing a long colorectal cancer surgery with the patient in the lithotomy position, particularly when laparoscopic surgery is planned.
SMEFF: A scalable memory extension fabric for FPGA

In resource-constrained FPGA systems, off-chip memory plays an important role in both prototype verification and acceleration systems for big data. As the scale of applications become increasingly large and complex, the data to be processed grows exponentially. In contrast, FPGAs provide limited memory capacity and bandwidth, severely limiting the scale and performance of prototype verification systems and acceleration systems. Furthermore, data movement is expected to be a dominant consumer of energy, thus inefficient data movement between different DRAM modules also incurs significant performance and energy penalties. This paper proposes a practical design: A Scalable Memory Extension Fabric for FPGA (SMEFF), which is an asynchronous memory access mechanism and exploits cascaded technology to solve the problem of memory capacity and bandwidth. SMEFF uses two key technologies to achieve memory capacity and bandwidth improvements, and shrink the latency and overhead of data movement-the first is an FPGA-based high-speed serial bus to build a multi-level memory fabric instead of the traditional parallel bus mechanism to solve the signal integrity problem. The second is a module to module (M-To-M) DMA data movement technology, which reduces the latency and overhead of data movement between memory modules. We implement SMEFF on an FPGA-based prototype to demonstrate the feasibility of our approach. Experimental results show that SMEFF provides 5x memory capacity increase and up to 3.6x memory bandwidth improvement compared to state-of-the-art FPGA-based memory systems, and outperforms PCIe-based systems. The data movement of M-TO-M's DMA technology obtains up to 3x latency reduction, and average of 21.1% to 61.1% energy reduction compared to state-of-the-art FPGA-based memory systems. SMEFF thus increases FPGA-based prototype memory systems capacity and bandwidth. More importantly, our architecture provides opportunities for the design of scalable, cost-effective FPGA-based memory subsystems.
Involvement of Corticotropin-Releasing Factor and Receptors in Immune Cells in Irritable Bowel Syndrome

Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder defined by ROME IV criteria as pain in the lower abdominal region, which is associated with altered bowel habit or defecation. The underlying mechanism of IBS is not completely understood. IBS seems to be a product of interactions between various factors with genetics, dietary/intestinal microbiota, low-grade inflammation, and stress playing a key role in the pathogenesis of this disease. The crosstalk between the immune system and stress in IBS mechanism is increasingly recognized. Corticotropin-releasing factor (CRF), a major mediator in the stress response, is involved in altered function in GI, including inflammatory processes, colonic transit time, contractile activity, defecation pattern, pain threshold, mucosal secretory function, and barrier functions. This mini review focuses on the recently establish local GI-CRF system, its involvement in modulating the immune response in IBS, and summarizes current IBS animal models and mapping of CRF, CRFR1, and CRFR2 expression in colon tissues. CRF and receptors might be a key molecule involving the immune and movement function via brain–gut axis in IBS.
Polypharmacology in Precision Oncology: Current Applications and Future  Prospects

Over the past decade, a more comprehensive, large-scale approach to studying cancer genetics and biology has revealed the challenges of tumor heterogeneity, adaption, evolution and drug resistance, while systems-based pharmacology and chemical biology strategies have uncovered a much more complex interaction between drugs and the human proteome than was previously anticipated. In this mini-review we assess the progress and potential of drug polypharmacology in biomarker-driven precision oncology. Polypharmacology not only provides great opportunities for drug repurposing to exploit off-target effects in a new single-target indication but through simultaneous blockade of multiple targets or pathways offers exciting opportunities to slow, overcome or even prevent inherent or adaptive drug resistance. We highlight the many challenges associated with exploiting known or desired polypharmacology in drug design and development, and assess computational and experimental methods to uncover unknown polypharmacology. A comprehensive understanding of the intricate links between polypharmacology, efficacy and safety is urgently needed if we are to tackle the enduring challenge of cancer drug resistance and to fully exploit polypharmacology for the ultimate benefit of cancer patients.
Soft-stop optimal trajectory control for improved operation of the series resonant multi-inverter

Induction heating technology is leading technical advances in home appliances due to the benefits inherent to the contactless energy transfer including high efficiency, fast heating, safety, cleanness and accurate control, among others. Recent advances are aimed at developing more versatile cooking surfaces for a superior user performance. In order to achieve such designs, new multiple-output power converters must be developed. The series resonant multi-inverter has been proposed as an efficient, versatile and cost-effective alternative to supply multi-inductor systems. However, several design challenges must be faced, including the required high blocking voltage of power devices, which may compromise the converter performance. This paper proposes an optimized modulation strategy to reduce this voltage, enabling an optimized converter design with improved reliability and performance. The proposed modulation is analytically studied and tested using an induction heating converter prototype, proving the feasibility of this proposal.
Carbohydrate Mouth Rinsing: Improved Neuromuscular Performance During Isokinetic Fatiguing Exercise.

PURPOSE To determine whether repeated carbohydrate (CHO) mouth rinsing would improve neuromuscular performance during high-intensity fatiguing contractions. METHODS Eighteen young men (age 26.1 ± 5.0 y, BMI 22.9 ± 1.9) performed 3 maximal voluntary isometric contractions (MVICPRE). Immediately after, they completed 10-second mouth rinse with 6.4% maltodextrin solution (MAL), 7.1% glucose solution (GLU), water (W), artificially sweetened solution (PLA), or a control trial with no rinse (CON) in a crossover protocol. Subjects performed 5 sets of 30 isokinetic fatiguing contractions at 180°/s, and an MVICPOST with their elbow flexors was performed after each mouth rinse. Mechanical and electromyographic (EMG) signals were recorded from the biceps brachii and parameters of interest analyzed. RESULTS When rinsing the mouth with a solution containing CHO, independently of the sweetness, isokinetic performance was enhanced as shown by the greater total work achieved in comparison with CON. The decay of torque and mean fiber-conduction velocity (MFCV) recorded at the end of the fatiguing task was lower when rinsing the mouth with GLU than with CON. The torque recorded during the MVICPOST was greater with CHO with respect to CON, and this was associated to a lower decay of MFCV. CONCLUSIONS CHO mouth rinse counteracts fatigue-induced decline in neuromuscular performance, supporting the notion that CHO rinse may activate positive afferent signals able to modify motor output. Repeated mouth rinsing with sweet and nonsweet CHO-containing solutions can improve neuromuscular performance during an isokinetic intermittent fatiguing task.
Trends and Characteristics of Occupational Suicide and Homicide in Farmers and Agriculture Workers, 1992–2010

OBJECTIVE We examined work-related homicides and suicides among farm operators/workers in the United States from 1992 to 2010. METHODS Work-related homicide and suicide cases from 1992 to 2010 were obtained from the Census of Fatal Occupational Injuries. To calculate rates, denominator data on the US working population were also obtained from 2003 to 2010 Current Population Survey. Logistic regression was used to identify factors that were differentially associated with homicide and suicide. RESULTS Over these 19 years, 171 farm operators/workers died from homicide and 230 died from suicide. When compared to rates of all workers, suicide rates were higher while homicide rates were lower among farm operators/workers. Males (OR = 6.1), whites (OR = 4.7), and 35- to 54-year-old (OR = 2.3) farm operators/workers had increased odds of suicide over homicide compared with their respective counterparts (ie, females, nonwhites, <35-year-olds). Those working in smaller farm operations with <11 employees had 1.7 times the odds of suicide over homicide. CONCLUSIONS Suicide and homicide are both present in the agricultural industry, with suicide being more common than homicide. Translation of suicide prevention programs should be explored for the agricultural industry.
A decentralized control strategy for economic operation of autonomous AC microgrids

Economic operation is a major concern for microgrids. Conventionally, economic dispatch of distributed generations (DGs) are solved by centralized control with optimization algorithms or distributed control with consensus algorithm. To improve the reliability, scalability and economy of microgrids, a fully decentralized economic power sharing strategy is proposed in this paper. The proposed method is based on frequency/incremental cost droop (f/IC) characteristics and incremental cost (IC) functions of DGs. ICs of DGs reach equality with the convergence of system frequency. Power dispatch of each DG is automatically achieved based on its relevant incremental cost function. Therefore, by using this method, the incremental cost of each DG will reach equality autonomously and the total operating cost can be optimized without any communication or central controllers. Simulation platform of an autonomous AC MG with three DGs is built in Matlab/Simulink to verify the effectiveness of the proposed method.
Comparison of Species and Cell-Type Differences in Fraction Unbound of Liver Tissues, Hepatocytes, and Cell Lines

Fraction unbound (fu) of liver tissue, hepatocytes, and other cell types is an essential parameter used to estimate unbound liver drug concentration and intracellular free drug concentration. fu,liver and fu,cell are frequently measured in multiple species and cell types in drug discovery and development for various applications. A comparison study of 12 matrices for fu,liver and fu,cell of hepatocytes in five different species (mouse, rat, dog, monkey, and human), as well as fu,cell of Huh7 and human embryonic kidney 293 cell lines, was conducted for 22 structurally diverse compounds with the equilibrium dialysis method. Using an average bioequivalence approach, our results show that the average difference in binding to liver tissue, hepatocytes, or different cell types was within 2-fold of that of the rat fu,liver. Therefore, we recommend using rat fu,liver as a surrogate for liver binding in other species and cell types in drug discovery. This strategy offers the potential to simplify binding studies and reduce cost, thereby enabling a more effective and practical determination of fu for liver tissues, hepatocytes, and other cell types. In addition, fu under hepatocyte stability incubation conditions should not be confused with fu,cell, as one is a diluted fu and the other is an undiluted fu. Cell density also plays a critical role in the accurate measurement of fu,cell.
Computational Modeling of β-Secretase 1 (BACE-1) Inhibitors Using Ligand Based Approaches

The binding affinities (IC50) reported for diverse structural and chemical classes of human β-secretase 1 (BACE-1) inhibitors in literature were modeled using multiple in silico ligand based modeling approaches and statistical techniques. The descriptor space encompasses simple binary molecular fingerprint, one- and two-dimensional constitutional, physicochemical, and topological descriptors, and sophisticated three-dimensional molecular fields that require appropriate structural alignments of varied chemical scaffolds in one universal chemical space. The affinities were modeled using qualitative classification or quantitative regression schemes involving linear, nonlinear, and deep neural network (DNN) machine-learning methods used in the scientific literature for quantitative-structure activity relationships (QSAR). In a departure from tradition, ∼20% of the chemically diverse data set (205 compounds) was used to train the model with the remaining ∼80% of the structural and chemical analogs used as part of an external validation (1273 compounds) and prospective test (69 compounds) sets respectively to ascertain the model performance. The machine-learning methods investigated herein performed well in both the qualitative classification (∼70% accuracy) and quantitative IC50 predictions (RMSE ∼ 1 log). The success of the 2D descriptor based machine learning approach when compared against the 3D field based technique pursued for hBACE-1 inhibitors provides a strong impetus for systematically applying such methods during the lead identification and optimization efforts for other protein families as well.