Miracle-dz/UniFAR-FTUs huggingface dataset:
Time-Dependent Impact of Diabetes on Mortality in Patients After Major Lower Extremity Amputation

OBJECTIVE To estimate the impact of diabetes on mortality in patients after first major lower extremity amputation (LEA). RESEARCH DESIGN AND METHODS Using claims data of a nationwide statutory health insurance, we assessed all deaths in a cohort of all 444 patients with a first major LEA since 2005 (71.8% male; mean age 69.1 years; 58.3% diabetic; 43% with amputation above the knee) up to 2009. Using Cox regression, we estimated the time-dependent hazard ratios to compare patients with and without diabetes. RESULTS The cumulative 5-year mortality was 68% in diabetic and 59% in nondiabetic individuals. In the first course, mortality was lower in diabetic compared with nondiabetic patients. Later, the diabetes risk increased yielding crossed survival curves after 2 to 3 years (time dependency of diabetes; P = 0.003). Age- and sex-adjusted hazard ratios for diabetes were as follows: 0–30 days: 0.50 [95% CI 0.31–0.84]; 31–60 days: 0.60 [0.25–1.41]; 61 days to 6 months: 0.75 [0.38–1.48]; >6–12 months: 1.27 [0.63–2.53]; >12–24 months: 1.65 [0.88–3.08]; >24–36 months: 2.02 [0.80–5.09]; and >36–60 months: 1.91 [0.70–5.21]. The pattern was similar in both sexes. In the full model, significant risk factors for mortality were age (1.05; 1.03–1.06), amputation above the knee (1.50; 1.16–1.94), and quartile category 3 or 4 of the number of prescribed medications (1.64; 1.12–2.40 and 1.76; 1.20–2.59). Further adjustment for comorbidity did not alter the results. CONCLUSIONS In this population-based study, we found a time-dependent mortality risk of diabetes following first major LEA, which may be in part a result of a healthier lifestyle in diabetic patients or the access to specific treatment structures in diabetic individuals.
Single-cell genomics reveals potential for magnetite and greigite biomineralization in an uncultivated multicellular magnetotactic prokaryote.

For magnetic orientation, magnetotactic bacteria biosynthesize magnetosomes, which consist of membrane-enveloped magnetic nanocrystals of either magnetite (Fe3 O4 ) or greigite (Fe3 S4 ). While magnetite formation is increasingly well understood, much less is known about the genetic control of greigite biomineralization. Recently, two related yet distinct sets of magnetosome genes were discovered in a cultivated magnetotactic deltaproteobacterium capable of synthesizing either magnetite or greigite, or both minerals. This led to the conclusion that greigite and magnetite magnetosomes are synthesized by separate biomineralization pathways. Although magnetosomes of both mineral types co-occurred in uncultured multicellular magnetotactic prokaryotes (MMPs), so far only one type of magnetosome genes could be identified in the available genome data. The MMP Candidatus Magnetomorum strain HK-1 from coastal tidal sand flats of the North Sea (Germany) was analysed by a targeted single-cell approach. The draft genome assembly resulted in a size of 14.3 Mb and an estimated completeness of 95%. In addition to genomic features consistent with a sulfate-reducing lifestyle, we identified numerous genes putatively involved in magnetosome biosynthesis. Remarkably, most mam orthologues were present in two paralogous copies with highest similarity to either magnetite or greigite type magnetosome genes, supporting the ability to synthesize magnetite and greigite magnetosomes.
Commonality and specificity of personality disorder profiles in subjects with trauma histories.

Recently, attention has been drawn to a range of disturbances in personality functioning that commonly characterize individuals with a history of severe or prolonged trauma. Many of these features overlap with criteria for some of the Axis II personality disorders. The current study investigated the similarity of personality disorder features in different samples of patients with trauma histories, and specificity of such features compared to other psychiatric samples. Profiles of Axis II features, based on relative frequencies of individual disorder "diagnoses" derived from a common measure (Personality Diagnostic Questionnaire-Revised), were compared in three trauma samples: male Vietnam combat veterans with PTSD, female inpatients with a history of childhood sexual abuse, and female outpatients with a history of childhood sexual abuse. The PDQ-R derived profiles in each of the three trauma samples were then compared with similar PDQ-R derived profiles in published reports of psychiatric samples selected for other diagnoses. Each of the three Spearman rank correlations among the three trauma samples were significant, ranging from . 72 to . 94. There was a clear pattern of higher correlations within the trauma samples (average correlation of .81) than between the trauma and nontrauma samples (average correlations of .11, .36, and .25 between the nontrauma samples and the combat sample, inpatient sexual abuse sample, and outpatient sexual abuse sample, respectively). The findings suggest that a pattern of personality disorder features may be distinctly associated with individuals with trauma histories, at least of the type examined here. Future studies using more clinically valid measures of personality features and including other types of trauma samples are needed to determine the generalizability of the current findings. Also needed are studies with longitudinal designs to address questions of causal pathways that may underlie such associations.
Risk of dementia in parents of probands with and without the apolipoprotein E4 allele. The EVA study.

STUDY OBJECTIVE: Age, family history of dementia and the epsilon 4 allele of the apolipoprotein E gene have been associated with Alzheimer's disease (AD). Considering the strength of APOE-epsilon 4 as a genetic risk factor for AD, this factor might explain a large part of the association between AD and a family history of dementia. Therefore, in the general population, a higher frequency of dementia should be observed among parents of probands with at least one epsilon 4 allele than in parents of probands without this allele. DESIGN, SETTING, AND PARTICIPANTS: The study investigated a sample of 1153 volunteers between 59 and 71 years old, genotyped for the APOE gene, all participating in the EVA study. Dementia in their parents was determined using a self reported questionnaire. MAIN RESULTS: The frequency of dementia in 2164 parents was examined and it was found that 245 were demented. The percentage of demented parents was 13.0% in the subgroup of parents of subjects having one or two epsilon 4 alleles and 10.8% in the other subgroup. The relative risk of dementia among parents according to the APOE-epsilon 4 status of probands, was calculated using a Cox model adjusted for the educational level of parents and their history of stroke: RR = 1.21 (95% CI 0.90, 1.63). CONCLUSION: This lack of association supports the observation that in the general population, APOE-epsilon 4 cannot explain a large part of family history of dementia.
The e ects of shadows on depth perception in augmented reality on a mobile device

In the visual perception of depth in computer graphics, people rely on a number of cues, including depth of eld, relative size of objects in perspective, and shadows. This work focuses on shadows in Augmented Reality. An experiment was performed in order to measure the e ects of having virtual objects cast shadows on real objects. Users performed the task of placing a virtual object on a physical table, in an Augmented Reality environment displayed on a mobile device. The virtual object was either a cube or a sphere. The e ects of having shadows enabled was measured by time to task completion and the positional error. Qualitative measurements of the user experience were also made, through the use of questionnaires. The results showed a decrease in both positional error and time to task completion when shadows were enabled. The results also indicated that users placed the objects with a higher degree of certainty when shadows were enabled. The quantitative and qualitative results of the experiment showed that users found it easier to perceive the position of the virtual object with respect to the physical object when the virtual object cast shadows.
PiMPeR: Piecewise Dense 3D Reconstruction from Multi-View and Multi-Illumination Images

In this paper, we address the problem of dense 3D reconstruction from multiple view images subject to strong lighting variations. In this regard, a new piecewise framework is proposed to explicitly take into account the change of illumination across several wide-baseline images. Unlike multiview stereo and multi-view photometric stereo methods, this pipeline deals with wide-baseline images that are uncalibrated, in terms of both camera parameters and lighting conditions. Such a scenario is meant to avoid use of any specic imaging setup and provide a tool for normal users without any expertise. To the best of our knowledge, this paper presents the rst work that deals with such unconstrained setting. We propose a coarse-to-ne approach, in which a coarse mesh is
Axon guidance molecule semaphorin3A is a novel tumor suppressor in head and neck squamous cell carcinoma

Semaphorin3A (SEMA3A), an axon guidance molecule in the nervous system, plays an inhibitory role in oncogenesis. Here, we investigated the expression pattern and biological roles of SEMA3A in head and neck squamous cell carcinoma (HNSCC) by gain-of-function assays using adenovirus transfection and recombinant human SEMA3A protein. In addition, we explored the therapeutic efficacy of SEMA3A against HNSCC in vivo. We found that lower expression of SEMA3A correlated with shorter overall survival and had independent prognostic importance in patients with HNSCC. Both genetic and recombinant SEMA3A protein inhibited cell proliferation and colony formation and induced apoptosis, accompanied by decreased cyclin E, cyclin D, CDK2, CDK4 and CDK6 and increased P21, P27, activated caspase-5 and caspase-7. Moreover, over-expression of SEMA3A suppressed migration, invasion and epithelial-to-mesenchymal transition due in part to the inhibition of NF-κB and SNAI2 in HNSCC cell lines. Furthermore, intratumoral SEMA3A delivery significantly stagnated tumor growth in a xenograft model. Taken together, our results indicate that SEMA3A serves as a tumor suppressor during HNSCC tumorigenesis and a new target for the treatment of HNSCC.
Generating and Justifying Design Theory

This paper applies Simon’s (1996) sciences of the artificial to elaborate a set of structures and processes for developing design theory. Goals, kernel theory, and artifacts inform an inter-related prototyping cycle of design, evaluation, and appropriation / generation to produce strategic design theory. The paper identifies DSR project types to provide signposts for starting and ending the cycle, artifact and evaluation iteration to facilitate the process and provide a chain of evidence, a simplified format for representing design theory iterations, and stopping rules to end the cycle. We use a detailed example to illustrate the ideas, discuss related work, and identify limitations and future research opportunities.
Mortality from non-communicable diseases in South Africa, 1997-2009

There are estimates of the magnitude of non-communicable disease deaths for less developed countries but little is known about the dynamics in Africa. The continent is undergoing unprecedented growth of the elderly population. This raises the need to examine mortality from non-communicable diseases. This study examines mortality attributable to non-communicable diseases in South Africa during the period 1997-2009. The data used are the death records for the period 1997-2009. Standardised crude death rates were computed. Logistic regression was used to examine the odds of dying from non-communicable diseases controlling for covariates. The results indicate that cardiovascular diseases had the highest death rate as immediate or underlying causes of death during the period 1997-2009. Sex, level of education and the type of industry of employment as well as the smoking status of the deceased were found to be significantly associated with the odds of dying from non-communicable diseases in South Africa.
The Bezold‐Jarisch Reflex in the Conscious Dog

The Bezold-Jarisch reflex was studied in 22 conscious, instrumented dogs. Specific left ventricular receptor stimulation was elicited by the circumflex coronary artery injection of veratridine in doses ranging from 0.01 to 0.40 μg/kg. None of these doses resulted in any hemodynamic effects when given intravenously. Heart rate, arterial blood pressure, left ventricular pressure, left ventricular dp/dt, and cardiac output were monitored and total peripheral resistance calculated. Dose-related decreases in arterial blood pressure and heart rate were observed following intracoronary injection of veratridine. Decreases were also noted in dp/dt max, left ventricular pressure, and cardiac output. With the heart paced to prevent bradycardia, the decrease in all the above parameters was significantly attenuated; however, a significant decrease in total peripheral resistance was still observed (−30.2 ± 3.7%). Cardiac pacing plus the administration of the α-adrenergic-blocking agent, phentolamine, blocked the decrease in total peripheral resistance when compared to pacing alone. The administration of atropine significantly attenuated the bradycardia, hypotension, decrease in dp/dt max, and decrease in total peripheral resistance in response to intracoronary veratridine. Atropine plus phentolamine abolished the decrease in total peripheral resistance that was evoked by intracoronary veratridine. The decrease in dp/dt max which resulted from veratridine administration was induced largely by the associated bradycardia, since both cardiac pacing and atropine significantly attenuated it. These experiments Indicate that the chemical stimulation of left ventricular receptors in the conscious dog mediates a bradycardia, hypotension and decrease in total peripheral resistance which is produced by sympathetic withdrawal as well as cholinergic vasodilation. There is no significant inotropic effect elicited by the stimulation of these receptors.
Multipliers of periodic orbits in spaces of rational maps

Abstract Given a polynomial or a rational function f we include it in a space of maps. We introduce local coordinates in this space, which are essentially the set of critical values of the map. Then we consider an arbitrary periodic orbit of f with multiplier ρ⁄=1 as a function of the local coordinates, and establish a simple connection between the dynamical plane of f and the function ρ in the space associated to f. The proof is based on the theory of quasiconformal deformations of rational maps. As a corollary, we show that multipliers of non-repelling periodic orbits are also local coordinates in the space.
Prognostic Risk Estimates of Patients with Multiple Sclerosis and Their Physicians: Comparison to an Online Analytical Risk Counseling Tool

Background Prognostic counseling in multiple sclerosis (MS) is difficult because of the high variability of disease progression. Simultaneously, patients and physicians are increasingly confronted with making treatment decisions at an early stage, which requires taking individual prognoses into account to strike a good balance between benefits and harms of treatments. It is therefore important to understand how patients and physicians estimate prognostic risk, and whether and how these estimates can be improved. An online analytical processing (OLAP) tool based on pooled data from placebo cohorts of clinical trials offers short-term prognostic estimates that can be used for individual risk counseling. Objective The aim of this study was to clarify if personalized prognostic information as presented by the OLAP tool is considered useful and meaningful by patients. Furthermore, we used the OLAP tool to evaluate patients' and physicians' risk estimates. Within this evaluation process we assessed short-time prognostic risk estimates of patients with MS (final n = 110) and their physicians (n = 6) and compared them with the estimates of OLAP. Results Patients rated the OLAP tool as understandable and acceptable, but to be only of moderate interest. It turned out that patients, physicians, and the OLAP tool ranked patients similarly regarding their risk of disease progression. Both patients' and physicians' estimates correlated most strongly with those disease covariates that the OLAP tool's estimates also correlated with most strongly. Exposure to the OLAP tool did not change patients' risk estimates. Conclusion While the OLAP tool was rated understandable and acceptable, it was only of modest interest and did not change patients' prognostic estimates. The results suggest, however, that patients had some idea regarding their prognosis and which factors were most important in this regard. Future work with OLAP should assess long-term prognostic estimates and clarify its usefulness for patients and physicians facing treatment decisions.
Endosymbiont interference and microbial diversity of the Pacific coast tick, Dermacentor occidentalis, in San Diego County, California

The Pacific coast tick, Dermacentor occidentalis Marx, is found throughout California and can harbor agents that cause human diseases such as anaplasmosis, ehrlichiosis, tularemia, Rocky Mountain spotted fever and rickettsiosis 364D. Previous studies have demonstrated that nonpathogenic endosymbiotic bacteria can interfere with Rickettsia co-infections in other tick species. We hypothesized that within D. occidentalis ticks, interference may exist between different nonpathogenic endosymbiotic or nonendosymbiotic bacteria and Spotted Fever group Rickettsia (SFGR). Using PCR amplification and sequencing of the rompA gene and intergenic region we identified a cohort of SFGR-infected and non-infected D. occidentalis ticks collected from San Diego County. We then amplified a partial segment of the 16S rRNA gene and used next-generation sequencing to elucidate the microbiomes and levels of co-infection in the ticks. The SFGR R. philipii str. 364D and R. rhipicephali were detected in 2.3% and 8.2% of the ticks, respectively, via rompA sequencing. Interestingly, next generation sequencing revealed an inverse relationship between the number of Francisella-like endosymbiont (FLE) 16S rRNA sequences and Rickettsia 16S rRNA sequences within individual ticks that is consistent with partial interference between FLE and SFGR infecting ticks. After excluding the Rickettsia and FLE endosymbionts from the analysis, there was a small but significant difference in microbial community diversity and a pattern of geographic isolation by distance between collection locales. In addition, male ticks had a greater diversity of bacteria than female ticks and ticks that weren’t infected with SFGR had similar microbiomes to canine skin microbiomes. Although experimental studies are required for confirmation, our findings are consistent with the hypothesis that FLEs and, to a lesser extent, other bacteria, interfere with the ability of D. occidentalis to be infected with certain SFGR. The results also raise interesting possibilities about the effects of putative vertebrate hosts on the tick microbiome.
Managing higher education and the MBA programme

What is it to teach higher education management? Over the years, the course team responsible for the MBA in higher education management at the Institute of Education have returned to this question when ideas for new modules have come forward, when existing material has been reviewed, when student evaluations have been studied or simply when someone has asked, ‘What are we really trying to do here? ’. The claim of higher education studies as a distinct interdisciplinary field can, I think, be sustained without difficulty: it draws on most of the social science disciplines, plus a few others such as history and cultural theory, and attempts to integrate them in order better to understand both the organisational aspects of higher education and its (apparently, ever-widening) ramifications in matters including, to take a random sample, economic development, social mobility, international relations and regional planning. (The distinction between the study of higher education in this relatively modern and limited sense, and the actual work of universities and colleges, is one that is not always obvious to the wider world.) The teaching of higher education management, though, raises additional difficulties. As a recent colleague on the MBA team, David Watson (2009a), has written,
Species- and stage-specific antigens in exoerythrocytic stages of Plasmodium falciparum.

Numerous exoerythrocytic forms of Plasmodium falciparum ( PFEEF ) were obtained from the liver of the South American monkey, Cebus apella, for analysis of the antigens on this stage. As antigen for the fluorescent assay, 5-micron sections of liver fragments collected on day 5 following sporozoite inoculation and fixed in Carnoy's solution or kept in liquid nitrogen were used. Two types of fluorescent labeling of the PFEEF were identified: diffuse and peripheral. Each of 23 sera from individuals with P. falciparum infection acquired naturally by mosquito bite showed the diffuse and peripheral patterns of fluorescence at low serum dilutions (i.e., 1:10-1:100), but only peripheral staining at higher serum dilutions (i.e., 1:200-1:1,600). All other polyclonal sera tested showed only the diffuse pattern of fluorescence whatever the serum dilution used; this was true for P. falciparum infections acquired accidentally by blood transfusion, heterologous human infections with P. vivax, P. ovale, P. malariae or P. cynomolgi, and experimental animal infections with P. berghei, P. gallinaceum, or P. cynomolgi. Fluorescent antibody titers on PFEEF were generally 1-4 dilutions lower than on blood stages. No age-dependent pattern of fluorescence titers was found in 30 sera from individuals ranging in age from 2-78 years living in a malaria-endemic area. Twenty-six monoclonal antibodies directed to P. falciparum blood stages which reacted at high titers with rings, schizonts, merozoites, and gametocytes did not react with PFEEF antigen even when using the undiluted ascitic fluid. (ABSTRACT TRUNCATED AT 250 WORDS)
Metabolic Syndrome and Diabetes, Alone and in Combination, as Predictors of Cardiovascular Disease Mortality Among Men

OBJECTIVE To examine cardiovascular disease (CVD) mortality risk in men with diabetes only, metabolic syndrome only, and concurrent metabolic syndrome and diabetes. RESEARCH DESIGN AND METHODS We examined CVD mortality risk by metabolic syndrome and diabetes status in men from the Aerobics Center Longitudinal Study (ACLS) (mean ± SD age 45.1 ± 10.2 years). Participants were categorized as having neither diabetes nor metabolic syndrome (n = 23,770), metabolic syndrome only (n = 8,780), diabetes only (n = 532), or both (n = 1,097). The duration of follow-up was 14.6 ± 7.0 years with a total of 483,079 person-years of exposure and 1,085 CVD deaths. RESULTS Age-, examination year–, and smoking-adjusted CVD death rates (per 1,000 man-years) in men with neither metabolic syndrome nor diabetes, metabolic syndrome only, diabetes only, and both were 1.9, 3.3, 5.5, and 6.5, respectively. CVD mortality was higher in men with metabolic syndrome only (hazard ratio 1.8 [95% CI 1.5–2.0]), diabetes only (2.9 [2.1–4.0]), and both (3.4 [2.8–4.2]) compared with men with neither. The presence of metabolic syndrome was not associated (1.2 [0.8–1.7]) with higher CVD mortality risk in individuals with diabetes. In contrast, the presence of diabetes substantially increased (2.1 [1.7–2.6]) CVD mortality risk in individuals with metabolic syndrome. CONCLUSIONS The presence of diabetes was associated with a threefold higher CVD mortality risk, and metabolic syndrome status did not modify this risk. Our findings support the fact that physicians should be aggressive in using CVD risk–reducing therapies in all diabetic patients regardless of metabolic syndrome status.