Miracle-dz/UniFAR-FTUs huggingface dataset:
Synchronized network emulation: matching prototypes with complex simulations

Network emulation, in which real systems interact with a network simulation, is a common evaluation method in computer networking research. Until now, the simulation in charge of representing the network has been required to be real-time capable, as otherwise a time drift between the simulation and the real network devices may occur and corrupt the results. In this paper, we present our work on synchronized network emulation. By adding a central synchronization entity and by virtualizing real systems for means of control, we can build-up network emulations which contain both unmodified x86 systems and network simulations of any complexity.
High power femtosecond laser for generation of coherent extreme ultraviolet radiation

An optical parametric amplifier system pumped by 1 kHz, 8 mJ femtosecond laser pulses at 800 nm has been constructed to generate high intensity, infrared pulses (~ 3 mJ, 1400 nm, 40 fs) with a total conversion efficiency of ~ 40%. The femtosecond high intensity laser pulses at 800 nm and 1400 nm have been used for high order harmonic generation in a semi-infinitive gas cell and have allowed the achievement of bright phase-matched harmonic radiation in the extremeultraviolet and soft X-ray region.
HLA-B locus in Caucasian patients with carbamazepine hypersensitivity.

BACKGROUND A strong pharmacogenetic association has been reported in Chinese patients between human leukocyte antigen (HLA)-B*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS). METHODS We have genotyped the HLA-B alleles in 56 Caucasian patients with varying severities of CBZ hypersensitivity and 43 controls on CBZ without adverse effects. RESULTS None of our patients (including two with blistering skin rashes) were positive for the HLA-B*1502 allele. HLA-B*0702 allele may protect against severe CBZ hypersensitivity but warrants further study. Of secondary interest, the correlation between HLA-B*0801 and HLA-DR3, DQ2 and TNF -308 alleles (on the ancestral haplotype 8.1) is consistent with our previous findings. CONCLUSION HLA-B*1502 does not seem to be a marker for all forms of CBZ-induced hypersensitivity in a Caucasian population.
MEU Analysis of DECICLUS Approach for Multilingual Text Categorization

In this paper, we have showed a hybrid approach to categorize the multilingual text documents using supervised and unsupervised learning techniques. To serve the purpose, we have selected decision tree technique from supervised category and clustering technique from unsupervised category to form our hybrid system DECICLUS. In our following paper, we have also done analysis of our novel approach based on maintenance, efficiency, usability (MEU) which shows that our approach have potentials for multilingual text categorization.
Improved prediction of outcome in patients with severe acute pancreatitis by the APACHE II score at 48 hours after hospital admission compared with the APACHE II score at admission. Acute Physiology and Chronic Health Evaluation.

HYPOTHESIS The 48-hour APACHE (Acute Physiology and Chronic Health Evaluation) II score is a better predictor of pancreatic necrosis, organ failure, and mortality in patients with severe acute pancreatitis than the score at hospital admission. DESIGN A retrospective analysis of 125 patients with acute pancreatitis. SETTING A tertiary public teaching hospital. PATIENTS Patients with severe acute pancreatitis as defined by 3 or more Ranson criteria or a hospital stay of longer than 6 days. MAIN OUTCOME MEASURES Pancreatic necrosis, organ failure, and mortality. RESULTS A significant association was found between the 48-hour score and the presence of pancreatic necrosis (P<.001), organ failure (P =.001), and death (P<.001). By contrast, the APACHE II score at admission was significantly associated only with the presence of organ failure (P =.007). Deteriorating APACHE II scores over 48 hours were significantly associated with a fatal outcome (P =.03). The combined APACHE II score (defined as the sum of the admission and 48-hour scores) was significantly higher among nonsurvivors than survivors (P<.001), and was strongly associated with the presence of pancreatic necrosis (P =.001) and organ failure (P<.001). The 48-hour and combined scores accurately predicted outcome in 93% of the patients compared with 75% by the admission score. CONCLUSIONS The 48-hour APACHE II score has improved predictive value compared with the admission score for identifying patients with severe acute pancreatitis who have a poor outcome. A deteriorating APACHE II score at 48 hours after admission may identify patients at risk for an adverse outcome.
Rheology and Dispersion Behavior of Ethylene‐Vinyl Acetate Copolymers/TiO2 Masterbatches Prepared by Melt‐Compounding

The rheology and dispersion behavior of ethylene‐vinyl acetate (EVA) copolymer/TiO2 masterbatches prepared by melt‐compounding were investigated. The pure EVA exhibits obviously pseudoplastic behavior and the apparent viscosity decreases remarkably at experimental temperatures, especially in the range of 100–500 s−1. The EVA/TiO2 masterbatches exhibit similar shear rheology behavior with pure EVA and the apparent viscosities are obviously higher than that of pure EVA when the TiO2 content is above 10 wt. %. Field‐emission scanning electron microscopy (FE‐SEM) and energy dispersive x‐ray spectroscopy (EDX) show that relatively low TiO2 loading and moderate shear rate are helpful for the improvement of dispersion behavior of TiO2 nanoparticles; moreover, the dispersion behavior of TiO2 greatly influences the melt viscosity. The extensional rheology of pure EVA decreases with increasing extension rate, especially at low melt temperatures. EVA/TiO2 masterbatches have similar extensional rheology behavior as pure EVA and the TiO2 loading has almost no influence on the extensional viscosity of materbatches.
Combination Immunotherapy of B-Cell Non-Hodgkin’s Lymphoma with Rituximab and Interleukin-2

Purpose: Cytokine-induced modulation of innate immunity is being explored to enhance the activity of monoclonal antibodies. Severe combined immunodeficient (SCID) mice engrafted with peripheral blood leukocytes (PBLs) from Epstein Barr virus-seropositive donors develop human B-cell non-Hodgkin’s lymphomas [B-NHLs (hu-PBL-SCID mouse model)]. We used this hu-PBL-SCID mouse model to study the synergism between interleukin (IL)-2 and rituximab. We also conducted a phase I trial of IL-2 and rituximab in relapsed B-NHL to study whether expansion of natural killer (NK) cells and enhanced cellular cytotoxicity could be safely accomplished in vivo. Experimental Design: Hu-PBL-SCID mice were treated with various schedules of rituximab and IL-2, with survival as the end point. Patients with relapsed B-NHL received rituximab (375 mg/m2 weekly × 4) followed by daily low-dose IL-2 (1 MIU/m2/day × 4 weeks) with pulses of intermediate-dose IL-2 (3–15 MIU/m2). Toxicity, NK cell numbers, and cellular cytotoxicity were measured. Results: In the hu-PBL-SCID mouse, the combination of rituximab and IL-2 showed greater activity against B-NHL than either agent alone. Treatment was most effective when IL-2 was given before rituximab. Twelve patients with heavily pretreated B-NHL entered the phase I trial. Toxicity was manageable, and responses were observed. NK cell expansion and enhanced cellular cytotoxicity against a B-cell lymphoma target were observed but did not correlate with response. Conclusions: The combination of IL-2 and rituximab is synergistic against B-NHL in the hu-PBL-SCID model. In the phase I trial, a sequential combination of rituximab and IL-2 was well tolerated and achieved biological end points. Responses were observed.
A Mitogenomic Phylogeny of Living Primates

Primates, the mammalian order including our own species, comprise 480 species in 78 genera. Thus, they represent the third largest of the 18 orders of eutherian mammals. Although recent phylogenetic studies on primates are increasingly built on molecular datasets, most of these studies have focused on taxonomic subgroups within the order. Complete mitochondrial (mt) genomes have proven to be extremely useful in deciphering within-order relationships even up to deep nodes. Using 454 sequencing, we sequenced 32 new complete mt genomes adding 20 previously not represented genera to the phylogenetic reconstruction of the primate tree. With 13 new sequences, the number of complete mt genomes within the parvorder Platyrrhini was widely extended, resulting in a largely resolved branching pattern among New World monkey families. We added 10 new Strepsirrhini mt genomes to the 15 previously available ones, thus almost doubling the number of mt genomes within this clade. Our data allow precise date estimates of all nodes and offer new insights into primate evolution. One major result is a relatively young date for the most recent common ancestor of all living primates which was estimated to 66-69 million years ago, suggesting that the divergence of extant primates started close to the K/T-boundary. Although some relationships remain unclear, the large number of mt genomes used allowed us to reconstruct a robust primate phylogeny which is largely in agreement with previous publications. Finally, we show that mt genomes are a useful tool for resolving primate phylogenetic relationships on various taxonomic levels.
Y chromosome microdeletion analysis reveals predominant AZFc deletions and absence of germline specific deletions among idiopathic infertile males in a south Indian population

Y chromosome microdeletions in any of the three azo ospermia factor loci AZFa, AZFb and AZFc affects spermatogenesis causing irreversible male infertili ty. In the present study Yq deletion frequency, del etion types and associated infertile conditions were analyzed among 240 idiopathic infertile males (102 severe oligosp ermic and 138 azoospermic) and 100 fertile control individuals of a south Indian population previously not assessed. Polymerase chain reaction analysis for Yq microdeletions was p erformed using genomic DNA employing eight sequence tagged sites markers. Germ line specific Yq deletions were also assessed among 86 severe oligospermic males u sing sperm DNA. Apart from these, sperm sex chromosomal aneup loidies were analyzed among 20 severe oligospermic and oligoasthenospermic infertile individuals through f luorescence in situ hybridization technique. Among 240 infertile individuals assessed 13 (5.4%) men were identified to harbour interstitial Y chromosome microdeletions . AZFc region deletions involving DAZ gene cluster was observed to be predominant (69.2% ) followed by AZFb deletions (15.4%) and AZFbc deletions (15.4%). Statistically significant difference was observed in the Yq delet ion frequency between the severe oligospermic and azoospermic ind viduals (χ = 4.13, df =1, p = 0.042). Germ line specific deletions were observed to be completely lacking am ong severe oligospermic individuals. Insignificant difference was observed in sperm sex chromosomal aneuploidy ra tes between the oligospermic and control individual s. Influence of genetic and environmental factors, sam pling and methodological differences can be attribu ed to the differences in Yq deletion frequency observed withi n Indian populations. Germ cell specific Yq deletio ns and sperm sex chromosome aneuploidy may not be always associa ted with severe infertility.
Differential localization of protein kinase A type II isozymes in the Golgi-centrosomal area.

Selectivity in the action of cAMP may be mediated by compartmentalized pools of cyclic AMP-dependent protein kinase (PKA). PKA type II is directed to different subcellular loci by interaction of the type II regulatory subunits (RIIalpha, RIIbeta) with A-kinase anchoring proteins. In order to separately investigate the subcellular localization of PKA type II isozymes, monospecific antibodies to human RIIalpha and RIIbeta subunits of PKA were developed. We demonstrate that centrosomes bind both RIIalpha and RIIbeta. Centrosomes were the preferred intracellular anchoring site for RIIbeta. However, centrosomal localization of RIIbeta was observed only in some highly differentiated cells such as keratinocytes, granulosa cells, and macrophages and in all neoplastic cell lines examined. Centrosomal localization of RIIbeta was not observed in normal undifferentiated cells such as fibroblasts, myoblasts, and T and B cells. In contrast, RIIalpha was abundant in the Golgi area and in the trans-Golgi network (TGN). Furthermore, although RIIalpha appeared to colocalize with microtubules in the Golgi/TGN, extractions with nonionic detergent demonstrated that RIIalpha was mainly membrane-associated. In addition, alterations of microtubule dynamics with Nocodazole or Taxol affected the distribution of the detergent-extractable pool of RIIalpha, indicating that RIIalpha may localize with microtubule-associated vesicles. Thus, RIIalpha and RIIbeta clearly localize differently in the Golgi-centrosomal region. This indicates specific roles for PKA isozymes containing either RIIalpha or RIIbeta.
Relations between pore structure parameters and their implications for characterization of MCM-41 using gas adsorption and X-ray diffraction

Structural parameters for ordered mesoporous materials are shown to be strongly interrelated as a result of their well-defined structures. Equations for mesoporous materials with hexagonal arrays of uniform pores (e.g., MCM-41 and SBA-15) are presented, which can be used to calculate the pore size, pore wall thickness, and specific surface area on the basis of several quantities, which are easily available from X-ray diffraction and gas adsorption data (i.e., the interplanar spacing, primary mesopore volume, and micropore volume). The influence of assumptions about the pore shape, pore wall density, and the presence of microporosity or disordered nonmesostructured domains on the evaluation of structural parameters is examined. It is suggested that because of very large specific surface areas and primary mesopore volumes for many MCM-41 materials, the existence of extensive disordered domains is not a common feature of MCM-41. Examination of X-ray diffraction (XRD) patterns and nitrogen adsorption isotherm.
Adaptive and autonomous thermal tracking for high performance computing systems

Many DTM schemes rely heavily on the accurate knowledge of the chip's dynamic thermal state to make optimal performance/ temperature trade-off decisions. This information is typically generated using a combination of thermal sensor inputs and various estimation schemes such as Kalman filter. A basic assumption used by such schemes is that the statistical characteristics of the power consumption do not change. This is problematic since such characteristics are heavily application dependent. In this paper, we first present autonomous schemes for detecting the change in the statistical characteristics of power and then propose adaptive schemes for capturing such new statistical parameters dynamically. This could enable accurate temperature estimation during runtime given dynamically changing power statistical states. Our schemes use a combination of hypothesis testing and residual whitening methods and can improve the accuracy by 67% as compared to the traditional non-adaptive schemes.
Design of Logical Topologies for Wavelength-Routed Optical Networks

The problem of designing a logical topology over a wavelength-routed all-optical network (AON) physical topology is studied. The physical topology consists of the nodes and fiber links in the network. On an AON physical topology, we can set up lightpaths between pairs of nodes, where a lightpath represents a direct optical connection without any intermediate electronics. The set of lightpaths along with the nodes constitutes the logical topology. For a given network physical topology and traffic pattern, our objective is to design the logical topology and the routing algorithm so as to minimize the network congestion while constraining the average delay seen by a source-destination pair and the amount of processing required at the nodes (degree of the logical topology). Ignoring the delay constraints can result in fairly convoluted logical topologies with very long delays. On the other hand, in all our examples, imposing it results in a minimal increase in congestion. While the number of wavelengths required to imbed the resulting logical topology on the physical all optical topology is also a constraint in general, we find that in many cases of interest this number can be quite small. We formulate the combined logical topology design and routing problem described above as a mixed integer linear programming problem which we then solve for a number of cases of a six-node network. This programming problem is split into two subproblems: logical topology design, and routing. We then compare the performance of several heuristic topology design algorithms against that of randomly generated topologies, as well as lower bounds.
Plasma Glycine and Risk of Acute Myocardial Infarction in Patients With Suspected Stable Angina Pectoris

Background Glycine is an amino acid involved in antioxidative reactions, purine synthesis, and collagen formation. Several studies demonstrate inverse associations of glycine with obesity, hypertension, and diabetes mellitus. Recently, glycine‐dependent reactions have also been linked to lipid metabolism and cholesterol transport. However, little evidence is available on the association between glycine and coronary heart disease. Therefore, we assessed the association between plasma glycine and acute myocardial infarction (AMI). Methods and Results A total of 4109 participants undergoing coronary angiography for suspected stable angina pectoris were studied. Cox regression was used to estimate the association between plasma glycine and AMI, obtained via linkage to the CVDNOR project. During a median follow‐up of 7.4 years, 616 patients (15.0%) experienced an AMI. Plasma glycine was higher in women than in men and was associated with a more favorable baseline lipid profile and lower prevalence of obesity, hypertension, and diabetes mellitus (all P<0.001). After multivariate adjustment for traditional coronary heart disease risk factors, plasma glycine was inversely associated with risk of AMI (hazard ratio per SD: 0.89; 95% CI, 0.82–0.98; P=0.017). The inverse association was generally stronger in those with apolipoprotein B, low‐density lipoprotein cholesterol, or apolipoprotein A‐1 above the median (all P interaction≤0.037). Conclusions Plasma glycine was inversely associated with risk of AMI in patients with suspected stable angina pectoris. The associations were stronger in patients with apolipoprotein B, low‐density lipoprotein cholesterol, or apolipoprotein A‐1 levels above the median. These results motivate further studies to elucidate the relationship between glycine and lipid metabolism, in particular in relation to cholesterol transport and atherosclerosis. Clinical Trial Registration URL: https://www.clinicaltrials. gov. Unique identifier: NCT00354081.
What is an unconscious emotion?(The case for unconscious "liking")

Ever since William James, psychologists of emotion have tended to view affective states as intrinsically conscious. We argue that nonconscious affect also exists, and focus specifically on the possibility of unconscious "liking". We present evidence that positive and negative affective reactions can be elicited subliminally, while a person is completely unaware of any affective reaction at all (in addition to being unaware of the causal stimulus). Despite the absence of any detectable subjective experience of emotion, subliminally induced unconscious "liking" can influence later consumption behaviour. We suggest that unconscious "liking" is mediated by specific subcortical brain systems, such as the nucleus accumbens and its connections. Ordinarily, conscious liking (feelings of pleasure) results from the interaction of separate brain systems of conscious awareness with those core processes of unconscious affect. But under some conditions, activity in brain systems mediating unconscious core "liking" may become decoupled from conscious awareness. The result is a genuinely unconscious emotion.
Mechanical properties of tissue determined by multiphoton microscopy

Mechanical models are important in many areas of medicine and physiological research. These are usually based on continuum mechanics using macroscopic mechanical parameters. However, knowledge of the microscopic structure of tissue, that is, the organization of structural proteins, gives useful information for improving such models for a given tissue. In this paper we image the structural changes in these proteins under strain by using multiphoton microscopy. This gives insight into the response to the tissue at microscopic level and can be used to modify existing mechanical models of tissue. Specifically we imaged the straightening of collagen fibers in bovine chordae tendinae and related this to the macroscopic strain applied to the tissue.
Electrochemical Properties of FeNiMm Electrodes for Hydrogen Evolution in Alkaline Solutions by VIM Technique

The FeNiMm (Mm = rare earth metals) electrodes have been successfully prepared by vacuum induction melting (VIM) technique and used to be active cathodes in chlor-alkali industry for the first time. The alloys are found that Mm content and Fe content has significant impact on the polarization characteristics of the FeNiMm electrodes. With the increasing of Mm content, the η200 change a little but the apparent exchange hard, and increasing the content of Fe and decreasing the content of Mm will have a negative effect on the electrocatalytic performance. Fe84.50Ni7. 72Mm7.72 was found to yield the highest intrinsic electrocatalytic activity. On the power interruption term, the cathodes exhibit excellent resistivity against repeated power interruptions.
Analysis of Leakage Current to Predict Insulator Flashover Using Artificial Neural Network

Problem statement: The phenomenon of flashover in polluted insulators has been continued by the study of the characteristics of contaminating layers deposited on the surface of insulators in high voltage laboratories. In the literature, Experimental investigations have been carried out on a real insulator or a flat plate model of insulators under high voltage application. This study proposed the Equivalent insulator flat plate model for studying the flashover phenomena due to pollution under wet conditions even at low voltage. Laboratory based tests were carried out on the model under AC voltage at different pollution levels. Different concentrations of salt solution has been prepared using sodium chloride, Kaolin and distilled water representing the various contaminations. Leakage current during the experimental studies were measured for various polluted conditions. Approach: A new model of Vc = f (V, Iinitial, Iem, Iemax and Iσ) based on artificial neural network has been developed to predict flashover from the analysis of leakage current. The input variable to the artificial neural network are mean (Imean), Maximum(Imax) and standard deviation(Iσ) of leakage current extracted along with the initial value of leakage current Iinitial and the input voltage(V). The target obtained was used to evaluate the performance of the neural network model. Results: The optimum process has been carried out based on the training accuracy measured by RMSE, the network converged to a threshold of 0.0001. The trained model prediction is in good agreement with the actual results and the R2 value of the developed model is 0.99996. Conclusion: The developed ANN model is well-suited for the analysis of leakage current to predict flashover on the insulator surface with high accuracy.