Miracle-dz/UniFAR-FTUs huggingface dataset:
The Construction of ITP Diagnostic Modeling Based on the Expressions of Hub Genes Associated with M1 Polarization of Macrophages

Purpose Primary immune thrombocytopenia (ITP) is an immune disease with a diagnosis of exclusion, since no validated biomarkers have been identified. In this study, we explored biomarkers associated with the development of ITP from an immune perspective to inform the clinical diagnosis. Patients and Methods Differentially expressed genes (DEGs) between normal and ITP samples were analyzed using limma package. Random forest algorithm and LASSO regression were further used to screen for DEGs associated with ITP. The expression of these hub genes was validated by PCR. The relationship between DEGs and immunity was explored by enrichment analysis. Immune cell infiltration in ITP was analyzed by CIBERSORT and ssGSEA, and the relationship between DEGs and infiltrating immune cells was analyzed by Spearman’s rank correlation analysis. Finally, a diagnostic model related to DEGs was constructed by the neural network, and its efficiency was detected by the ROC curve. Results After screening the GEO database and validation by PCR analysis, The expression of CTH and TAF8 were higher and while OSBP2 expression was lower in ITP patients compared to normal subjects (P<0.05). GO enrichment analysis showed that these DEGs were associated with inflammatory immune-related diseases, and KEGG analysis showed that they mainly regulated signaling pathways such as JAK-STAT. CIBERSORT and ssGSEA analyses showed that these DEGs were mainly associated with macrophage M1 polarization. The expression of CTH and TAF8 were positively correlated with M1 expression, while OSBP2 was negatively correlated with M1 expression. The ROC curve showed high accuracy of the neural network model [AUC= 0.939, 95% CI (0.8–1)]. Conclusion Our results suggest that CTH, TAF8, and OSBP2 can be used as effective diagnostic biomarkers of ITP.
Electron Spin Resonance on Si/SiGe Quantum Dots

Qubits in a solid state environment are promising candidates for large scale quantum computing, but they usually suffer short decoherence times. Electron spin qubits in silicon quantum dots are expected to have long coherence because of the weak spinorbit coupling and hyperfine interaction in silicon. In this thesis we study the spin relaxation and decoherence in Si/SiGe heterostructures using ensemble electron spin resonance (ESR), and report the first measured long coherence time of 250 μs of a single electron spin in a Si quantum dot. The first experiment was performed on a single gated Si/SiGe heterostructure device. We observed a residual ESR signal originating from the Si quantum well at gate voltages below the conduction threshold. The signal exhibits a Curie temperature dependence, leading us to attribute it to isolated electrons trapped by intrinsic disorder in the quantum well, referred as natural quantum dots. From these confined electron spins we measured the relaxation time, T1 ∼ 0.5 ms, and coherence time, T2 ∼ 16 μs. The long T1 and the fact that T1 T2 suggest a strong suppression of the Dyakonov-Perel relaxation mechanism, which arises from spin-orbit coupling and is dominant in two dimensional electron gases. The high density of natural quantum dots in this wafer suggests spin coherence is most likely limited by the electron exchange interaction between neighbouring dots. In the second experiment we fabricated a dual-gated structure on an ultra-high mobility, undoped Si/SiGe heterostructure wafer. The device accommodates ∼ 10 electrostatically gated quantum dots for ensemble ESR. Our data show that approximately one unpaired electron spin is confined per dot. At 0.35 K this single electron spin has a T1 of 280 μs and a T2 of 250 μs, demonstrating the expected long coherence of an electron spin in a silicon quantum dot. Both T1 and T2 have weak temperature dependencies from 0.35 K to 0.8 K, and show a non-monotonic dependence on the gate voltages. These results indicate that several possible mechanisms may be
Comparison of Rhinovirus A–, B–, and C–Associated Respiratory Tract Illness Severity Based on the 5′-Untranslated Region Among Children Younger Than 5 Years

Abstract Background Rhinoviruses (RVs) are among the most frequently detected viruses from hospitalized children with severe acute respiratory infections, being classified into RV-A, RV-B, and RV-C (4 clades: C, GAC1, GAC2, and A2). This study aimed to compare the clinical characteristics and respiratory tract illness severity between the RV species and RV-C clades in children in primary care and hospital settings in rural communities in the Philippines. Methods Clinical samples and information of children <5 years old in the Philippines were collected from 2014 to 2016. The samples were tested by reverse-transcription polymerase chain reaction (RT-PCR) targeting the 5′-untranslated region. PCR-positive samples were sequenced, and RV species were identified by phylogenetic analysis. Results Overall, 3680 respiratory tract illness episodes in 1688 cohort children were documented; 713 of those were RV positive and identified as RV-A (n = 271), RV-B (n = 47), and RV-C (n = 395: C [n = 76], GAG1 [n = 172], GAG2 [n = 8], A2 [n = 138], and unidentified [n = 1]). Severe illnesses, low oxygen saturation, cough, and wheezing were more common in patients with RV-C, especially with GAC1, than in those with RV-A or RV-B. Furthermore, severe illness was significantly more common in RV-C (GAC1)–positive cases than in RV-A–positive cases (odds ratio, 2.61 [95% CI, 1.17–4.13]). Conclusions Children infected with RV-C had more severe illnesses than children infected with RV-A and RV-B. Moreover, emerging clades of RV-C were associated with increased severity.
Population dynamics of western gorillas at Mbeli Bai

Long-term studies of population dynamics can provide insights into life history theory, population ecology, socioecology, conservation biology and wildlife management. Here we examine 25 years of population dynamics of western gorillas at Mbeli Bai, a swampy forest clearing in Nouabalé-Ndoki National Park, the Republic of Congo. The Mbeli population more than doubled from 101 to 226 gorillas during the study. After adjusting for a net influx of gorillas into the study population, the increase represents an inherent growth rate of 0.7% per year, with 95% confidence limits between -0.7% and 2.6%. The influx of gorillas mainly involved immigration of individuals into existing study groups (social dispersal), but it also included the appearance of a few previously unknown groups (locational dispersal). The average group size did not change significantly during the study, which is consistent with the possibility that western gorillas face socioecological constraints on group size, even when the population is increasing. We found no significant evidence of density dependence on female reproductive success or male mating competition. The distribution of gorillas among age/sex categories also did not change significantly, which suggests that the population had a stable age structure. Our results provide evidence of population stability or growth for some western gorillas (albeit within a small area). The results highlight the value of law enforcement, long-term monitoring, and protected areas; but they do not diminish the importance of improving conservation for this critically endangered species.
Gharial (Gavialis gangeticus, Gmelin, 1789) abundance in the Rapti River, Chitwan National Park, Nepal

Abstract Gharial (Gavialis gangeticus) is a Critically Endangered crocodilian species whose abundance in Nepalese rivers is low due to the threat they face. We estimated gharial abundance in the Rapti River, one of the major rivers in Chitwan National Park (CNP) holding the largest numbers of gharials in Nepal. The Rapti River, running across the CNP, was divided into 18 segments, each measuring ~4 km, and gharials were counted directly with three replicates. Gharial count data were analyzed using an N‐mixture model (negative binomial) and the overall occupancy of gharials was estimated using a single season occupancy model. Covariate effects were also investigated on gharial abundance. Our findings revealed that the Rapti River is home to 150 gharials (119–181), with a mean abundance of 8.3 (SD = 3.45) across each segment. The presence of humans and square of Rapti River depth were the significant covariates that had a negative and positive impact on gharial abundance, respectively. Similarly, the number of sandbank present influenced the detection probability of gharials. Our study shows that gharial population estimation can be improved using the N‐mixture model. The overall gharial occupancy estimated using single season occupancy model was 0.84 (SD = 0.08), with a detection probability of 0.37 (SD = 0.02). The management authority should concentrate on segments to minimize human disturbance (e.g., fishing, washing clothes, extraction of riverbed materials). If the gharial population in this river declines, their population in central Nepal will be threatened. Hence, we suggest designating the Rapti River section that passes across the CNP as a “no extraction zone. ”
Skin cell-derived extracellular vesicles: a promising therapeutic strategy for cutaneous injury

Abstract Wound healing refers to the healing process that occurs after the skin and other tissues are separated or damaged by internal or external forces. It is a complex combination of tissue regeneration, granulation tissue hyperplasia, and scar formation, and shows the synergistic effects of these processes. After skin damage, the environment around the wound and the cells at site of the damage respond immediately, and a range of cytokines and growth factors are released. In cutaneous injury, extracellular vesicle (EV) signaling plays a vital role in the healing process via paracrine and endocrine mechanisms. EVs are natural intercellular and inter-organ communication tools that carry various bioactive substances for message exchange. Stem cells and stem cell EVs facilitate tissue repair, showing promising potential in regenerative medicine. Nevertheless, EVs derived from specific skin tissue cells, such as epidermal cells, fibroblasts, vascular endothelial cells and inflammatory cells, also play important roles in cutaneous tissue repair. Here, we describe the characteristics of wound healing, concentrating on the production and functions of EVs derived from specific skin cells, and provide new ideas for wound therapy using EVs.
PROPERTIES OF CLOSED 3-BRAIDS

We classify the positive braid words with Morton-Williams-Franks bound 3 and show that closed positive braids of braid index 3 are closed positive 3-braids. Then we show that 3-braid links with given (non-zero) Alexander or Jones polynomial are nitely many, and can be effectively determined. We classify among closed 3-braids strongly quasipositive and bered ones, and show that 3-braid links have a unique incompressible Seifert surface. At last, we apply the Burau representation to obtain braid index criteria, also for braids on more strings, in particular, an efcient 4-braid test.
Supporting information v2

Exclusion of low quality antibody profiles Eleven of the 40 plasma samples from PNG adults and two of 40 from PNG children showed negligible reactivity to any of the VAR proteins; these donors were also seronegative for the positive control and EBNA1, and the Bradford Protein Assay (BioRad) revealed low levels of total protein in each of the samples (data not shown). These data indicated that these sera were of low quality and accordingly they were removed from subsequent analysis. In total, sera samples from 29 adults and 38 children were assayed. Additionally, one of the presumed malaria-naïve USA adults recognised a large number of PfEMP1 variants indicating prior exposure to P. falciparum; this sample therefore was excluded for the definition of background signal. In total, sera samples from ten presumptively malaria-naïve adults residing in the USA were used to determine the background non-specific recognition of each VAR protein.
A Small-Area Analysis in Taipei City, Taiwan

Background: Few studies have investigated whether means accessibility is related to the spatial distribution of suicide. Aims: To examine the hypothesis that indicators of the accessibility to specific suicide methods were associated with method-specific suicide rates in Taipei City, Taiwan. Method: Smoothed standardized mortality ratios for method-specific suicide rates across 432 neighborhoods and their associations with means accessibility indicators were estimated using Bayesian hierarchical models. Results: The proportion of single-person households, indicating the ease of burning charcoal in the home, was associated with charcoal-burning suicide rates (adjusted rate ratio [aRR] = 1.13, 95% credible interval [CrI] = 1.03–1.25). The proportion of households living on the sixth floor or above, indicating easy access to high places, was associated with jumping suicide rates (aRR = 1.16, 95% CrI, 1.04–1.29). Neighborhoods’ adjacency to rivers, indicating easy access to water, showed no statistical evidence of an association with drowning suicide rates (aRR = 1.27, 95% CrI = 0.92–1.69). Hanging and overall suicide rates showed no associations with any of these three accessibility indicators. Limitations: This is an ecological study; associations between means accessibility and suicide cannot be directly inferred as causal. Conclusion: The findings have implications for identifying high-risk groups for charcoal-burning suicide (e.g., vulnerable individuals living alone) and preventing jumping suicides by increasing the safety of high buildings.
The complexity of pure nash equilibria in max-congestion games

We study Network Max-Congestion Games (NMC games, for short), a class of network games where each player tries to minimize the most congested edge along the path he uses as strategy. We focus our study on the complexity of computing a pure Nash equilibria in this kind of games. We show that, for single-commodity games with non-decreasing delay functions, this problem is in P when either all the paths from the source to the target node are disjoint or all the delay functions are equal. For the general case, we prove that the computation of a PNE belongs to the complexity class PLS through a new technique based on generalized ordinal potential functions and a slightly modified definition of the usual local search neighborhood. We further apply this technique to a different class of games (which we call Pareto-efficient) with restricted cost functions. Finally, we also prove some PLS-hardness results, showing that computing a PNE for Pareto-efficient NMC games is indeed a PLS-complete problem.
The effect of grape products on liver enzymes: A systematic review and meta‐analysis of randomized controlled trials

The favorable influence of grape consumption on metabolic diseases has previously been shown in studies. We sought to assess the effects of grape intake on liver enzymes, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP), in adults. We performed literature search in online databases, to find eligible randomized controlled trials (RCTs). we considered RCTs that met the following criteria: RCTs consisted of use of grape products on ALT, AST, and ALP in adults (≥18 years) with at least 2 weeks intervention duration. Pooling data from 11 trials showed that grape products intake significantly reduced ALP (p = .010), without any significant changes in ALT (p = .234) and AST (p = .300). In subgroup analysis, we found a significant reduction in ALP, ALT, and AST when the duration of intervention was ≥12 weeks, and when grape seed extract (GSE) was administered. The variable duration and dosage of intervention was one of the sources of bias in our meta‐analysis. Additionally, participants involved in included studies had different physiological status and various age groups. Grape products administration may significantly improve ALT, AST, and ALP in adults in long‐term interventions and/or when GSE is administered. It should be noted that the favorable effects of grape consumption were small and may not reach clinical importance.
Attachment Orientations and Family Functioning: The Mediating Role of Emotion Regulation

Abstract Attachment insecurity has been found to be associated with poor family functioning. The mechanisms underlying this link, however, are less explored. This study examines the potential mediating role of emotion regulation in the association between attachment orientations and family functioning. Self-report scales measuring attachment, family functioning, and emotion regulation were administered to 132 adults (58% women; 57.63 years). Results showed that both attachment anxiety and attachment avoidance were associated with poor family functioning. Furthermore, emotion suppression, but not positive reappraisal, was found to partially mediate the association between attachment insecurity (both anxiety and avoidance) and perceived family functioning. Findings suggest that emotion regulation seems to play a role in the impact that attachment orientations may have on family functioning.
Novel approaches to energize microbial biocatalysts

Abstract An efficient and cheap energization of microbial biocatalysts is essential in current biotechnological processes. A promising alternative to the use of common organic or inorganic electron donors is the semiconductor nanoparticles (SNs) that absorb light and transfer electrons (photoelectrons) behaving as artificial photosynthetic systems (biohybrid systems). Excited photoelectrons generated by illuminated SNs are highly reductive and readily accepted by membrane‐bound proteins and electron shuttles to drive specific cell reduction processes and energy generation in microbes. However, the operational mechanisms of these hybrid systems are still poorly understood, especially at the material–microbe interface, and therefore the design and production of efficient biohybrids are challenging. Some major limitations/challenges and future prospects of SNs as microbial energization systems are discussed.
Social cognitive processes explain bias in juror decisions

Abstract Jury decisions are among the most consequential social decisions in which bias plays a notable role. While courts take measures to reduce the influence of non-evidentiary factors, jurors may still incorporate biases into their decisions. One common bias, crime-type bias, is the extent to which the perceived strength of a prosecutor’s case depends on the severity of the crime. Moral judgment, affect and social cognition have been proposed as core processes underlying this and other biases. Behavioral evidence alone has been insufficient to distinguish these explanations. To identify the mechanism underlying crime-type bias, we collected functional magnetic resonance imaging patterns of brain activation from mock jurors reading criminal scenarios. Brain patterns from crime-type bias were most similar to those associated with social cognition (mentalizing and racial bias) but not affect or moral judgment. Our results support a central role for social cognition in juror decisions and suggest that crime-type bias and cultural bias may arise from similar mechanisms.
Effects of Timed Frontal Plane Pelvic Moments During Overground Walking With a Mobile TPAD System

Robotic gait training may improve overground ambulation for individuals with poor control over pelvic motion. However, there is a need for an overground gait training robotic device that allows full control of pelvic movement and synchronizes applied forces to the user’s gait. This work evaluates an overground robotic gait trainer that applies synchronized forces on the user’s pelvis, the mobile Tethered Pelvic Assist Device. To illustrate one possible control scheme, we apply assistive frontal plane pelvic moments synchronized with the user’s continuous gait in real-time. Ten healthy adults walked with the robotic device, with and without frontal plane moments. The frontal plane moments corresponded to 10% of the user’s body weight with a moment arm of half their pelvic width. The frontal plane moments significantly increased the range of frontal plane pelvic angles from 2.6° to 9.9° and the sagittal and transverse planes from 4.6° to 10.1° and 3.0° to 8.3°, respectively. The frontal plane moments also significantly increased the activation of the left gluteus medius muscle, which assists in regulating pelvic obliquity. The right gluteus medius muscle activation did not significantly differ when frontal plane moments were applied. This work highlights the ability of the mobile Tethered Pelvic Assist Device to apply a continuous pelvic moment that is synchronized with the user’s gait cycle. This capability could change how overground robotic gait training strategies are designed and applied. The potential for gait training interventions that target gait deficits or muscle weakness can now be explored with the mobile Tethered Pelvic Assist Device.
The Burst and Transient Source Experiment (BATSE) Earth Occultation Catalog of Low-Energy Gamma-Ray Sources

The Burst and Transient Source Experiment (BATSE), aboard the Compton Gamma Ray Observatory (CGRO), provided a record of the low-energy gamma-ray sky (∼20-1000 keV) between 1991 April and 2000 May (9.1 yr). BATSE monitored the high-energy sky using the Earth occultation technique (EOT) for point sources whose emission extended for times on the order of the CGRO orbital period (∼92 min) or greater. Using the EOT to extract flux information, a catalog of sources using data from the BATSE Large Area Detectors has been prepared. The first part of the catalog consists of results from the all-sky monitoring of 58 sources, mostly Galactic, with intrinsic variability on timescales of hours to years. For these sources, we have included tables of flux and spectral data, and outburst times for transients. Light curves (or flux histories) have been placed on the World Wide Web. We then performed a deep-sampling of these 58 objects, plus a selection of 121 more objects, combining data from the entire 9.1 yr BATSE data set. Source types considered were primarily accreting binaries, but a small number of representative active galaxies, X-ray-emitting stars, and supernova remnants were also included. The sample represents a compilation of sources monitored and/or discovered with BATSE and other high-energy instruments between 1991 and 2000, known sources taken from the HEAO 1 A-4 and Macomb & Gehrels catalogs. The deep sample results include definite detections of 83 objects and possible detections of 36 additional objects. The definite detections spanned three classes of sources: accreting black hole and neutron star binaries, active galaxies, and supernova remnants. The average fluxes measured for the fourth class, the X-ray emitting stars, were below the confidence limit for definite detection. Flux data for the deep sample are presented in four energy bands: 20-40, 40-70, 70-160, and 160-430 keV. The limiting average flux level (9.1 yr) for the sample varies from 3.5 to 20 mcrab (5 σ) between 20 and 430 keV, depending on systematic error, which in turn is primarily dependent on the sky location. To strengthen the credibility of detection of weaker sources (∼5-25 mcrab), we generated Earth occultation images, searched for periodic behavior using FFT and epoch folding methods, and critically evaluated the energy-dependent emission in the four flux bands. The deep sample results are intended for guidance in performing future all-sky surveys or pointed observations in the hard X-ray and low-energy gamma-ray band, as well as more detailed studies with the BATSE EOT.