Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence of Hepatotoxicity From Antituberculosis Therapy

Background: Antituberculosis (ATT) drug-induced liver injury (DILI) is a common and serious adverse effect of tuberculosis (TB) treatment. This retrospective study was carried out to study the prevalence of DILI among patients who had received anti-TB medications and to study some of the known risk factors responsible for causing DILI. Materials and Methods: This longitudinal descriptive study was performed to evaluate cases of DILI with predefined criteria. Patients of all ages, diagnosed and treated for smear positive pulmonary TB from January 1, 2008 to December 31, 2012 and those who came for regular follow-up were included in the study. Multiple logistic regression analysis was performed to determine the association of different risk factors and DILI. The confounders considered were age, sex, weight, body mass index, doses of drugs (fixed or per kg), ATT regimens (daily or intermittent), and treatment categories. Results: Of the 253 patients analyzed, 24 (9.48%) developed DILI. Associations of different risk factors were insignificant; including chronic alcohol consumption, hepatitis B infection, hepatitis C infection, HIV infection, and existing chronic TB. Conclusion: DILI was not significantly associated with known risk factors in our settings.
Exenatide once-weekly injection for the treatment of type 2 diabetes in Chinese patients: current perspectives

Glucagon-like peptide-1 (GLP-1) analogs, such as exenatide, have played an important role as antidiabetic medications in the treatment of type 2 diabetes (T2DM). Like most other hypoglycemic agents, exenatide has a number of actions, including lowering blood glucose, promoting weight loss, improving insulin resistance, and protecting islet β-cells. Although GLP-1 analogs, combined with other antidiabetic medications, have excellent performance in T2DM, some side effects and imperfections limit its use in clinical practice. Since 2012, a new generation GLP-1 agent, exenatide once weekly (QW), has been available for patients with T2DM in the USA, but not as yet in the People’s Republic of China. Previous data indicate that exenatide QW achieves better fasting glucose reductions than sitagliptin or exenatide twice daily, whilst appearing non-inferior to pioglitazone and achieving less reductions than insulin glargine. Exenatide QW was better at improving average postprandial glucose than sitagliptin or titrated insulin glargine, but was inferior to exenatide twice daily. Additionally exenatide QW has a better effect in terms of weight loss than other glycemic medications. Exenatide QW can also reduce blood lipids and lower blood pressure. Accordingly, exenatide QW is cost-effective, achieves good clinical outcomes, and has acceptable side effects, indicating that it has promising prospects for future use in the People’s Republic of China.
Global demand for certified hardwood products as determined from a survey of hardwood exporters

U.S. hardwood exporters were surveyed to determine the current international markets for certified hardwood products (CHWP) and to document the experiences of hardwood exporters concerning CHWP and certification. There was a 42 percent response rate to the 265 mailed surveys. Twenty-six percent of exporting companies received requests for CHWP. These requests represented < 5 percent of the companies' total export business. The experiences of the responding exporters parallels that reported in previously published studies. 'Willingness to pay a premium is low. Over half of the exporters indicated that customers will not pay any premium. Chain-of-custody issues are a major problem and the supply of certified hardwood lumber is small. Only large companies owning their own forests have no problem with certification, chain-of-custody documentation, or supply. The markets remain predominantly niche markets centered in northern Europe. China is emerging as a major market for primary CHWP.
Depression and Mortality in People with Type 2 Diabetes Mellitus, 2003 to 2013: A Nationwide Population-Based Cohort Study

Background Previous reports have demonstrated a bidirectional relationship between depression and diabetes mellitus (DM), accentuating a need for more intensive depression screening in DM patients. There is a relative paucity of data on the mortality of depressed DM patients in Korea. Methods Retrospective data from January 2003 to December 2013 were collected for adult type 2 diabetes mellitus (T2DM) patients older than 30 years using the National Health Information database maintained by the Korean National Health Insurance Service (NHIS). Demographic characteristics were analyzed with descriptive statistics, and the annual prevalence of depression was estimated. Mortality rates and hazard ratios for each age group (stratified into six age groups) of patients diagnosed with T2DM in 2003 were estimated using a Cox proportional hazard method, with the Kaplan-Meier cumulative survival curve showing the overall survival rates according to the T2DM status until the given year of 2013. Results The annual prevalence of depression was consistently higher in T2DM group from 2003 to 2013. The mortality hazard ratio was higher in the depressed in all age groups, and the risk was higher in male groups and in younger-aged groups. Conclusion Depression was significantly associated with a high mortality risk in T2DM patients; hence, a more systematic surveillance of T2DM patients to identify risk factors for depression might contribute significantly to reducing mortality risk in this group of patients.
Impact of computed tomography myocardial perfusion following computed tomography coronary angiography on downstream referral for invasive coronary angiography, revascularization and, outcome at 12 months

Aims The aim of this study was to assess the impact of adding stress computed tomography (CT) myocardial perfusion (CTP) to coronary CT angiography (CTA) on downstream referral for invasive coronary angiography (ICA), revascularization, and outcome in patients presenting with new-onset chest pain. Methods and results Three hundred and eighty-four patients were referred for cardiac CT. Patients with lesions ≥50% stenosis underwent subsequently stress CTP. Perfusion scans were considered abnormal if a defect was observed in ≥ 1 segment. Downstream performance of ICA, revascularization, and the occurrence of major cardiovascular events (death, non-fatal myocardial infarction, and unstable angina requiring urgent revascularization) were assessed within 12 months. In total, 119 patients showed ≥50% stenosis on coronary CTA; stress CTP was normal in 61 patients, abnormal in 38 patients and was not performed in 20 patients. After normal stress CTP, 19 (31%) patients underwent ICA and 9 (15%) underwent revascularization. After abnormal stress CTP, 36 (95%) patients underwent ICA and 29 (76%) revascularizations were performed. Multivariable analyses showed a five-fold reduction in likelihood of proceeding to ICA when a normal stress CTP was added to a coronary CTA showing obstructive CAD. Major cardiovascular event rates at 12 months for patients with obstructive CAD and normal stress CTP (N = 61) were low: 1 myocardial infarction, 1 urgent revascularization, and 1 non-cardiac death. Conclusion The performance of stress CTP in patients with obstructive CAD at coronary CTA in the same setting is feasible and reduces the referral rate for ICA and revascularization. Secondly, the occurrence of major cardiovascular events at 12 months follow-up in patients with normal stress CTP is low.
Judging Statutes: Thoughts on Statutory Interpretation and Notes for a Project on the Internal Revenue Code

Positive analyses aimed at answering the question of why judges interpret statutes the way they do abound. Some authors suggest the primary determinant centers on the political ideology of the judges, others argue that jurists interpret statutes in a strategic fashion vis-a-vis the relevant actors in the playing field, and still others maintain that statutory interpretation has less to do with policy maximization than with principle maximization. To us, the most interesting features of the non-normative literature on statutory interpretation lie not on the distinctive conclusions generated, but rather on the commonalities. First, many of the relevant studies focus on civil rights legislation. This holds true regardless of whether the author is a legal academic or a social scientist, whether the research is primarily quantitative or qualitative, or whether the theoretical grounding is in psychology, sociology, political science, or economics. Second, almost all studies, especially those of the large-n quantitative variety, explore the outcomes reached by jurists and not the rationale or justification they invoke. These are not criticisms of the extant literature; in fact, we believe that by investigating outcomes reached in civil rights cases, authors have revealed a great deal about the "judicial mind. " At the same time, we believe just as firmly that if we are to understand fully the determinants of statutory interpretation, then the emphases on civil rights and outcomes impose serious limitations. Accordingly, we have a devised a project that aspires to address these concerns by (1) exploring Supreme Court tax opinions, a large body of case law that, despite its importance, has received virtually no systematic attention, and (2) taking into account both outcomes and rationales. In this Article, we do not present results (other than the most preliminary findings) given that our data collection is still underway. Rather, we make the case for moving beyond the arena of civil rights, and for incorporating rationales into models of statutory interpretation.
Cloning and Functional Characterization of Two 4-Coumarate: CoA Ligase Genes from Selaginella moellendorffii

Selaginella is an extant lycopodiophyte genus, which is representative of an ancient lineage of tracheophytes. The important evolutionary status makes it a valuable resource for the study of metabolic evolution in vascular plants. 4-coumarate: CoA ligase (4CL) is the pivotal enzyme that controls the flow of carbon through the phenylpropanoid metabolic pathway into the specific lignin, flavonoid, and wall-bound phenolics biosynthesis pathways. Although 4CLs have been extensively characterized in other vascular plants, little is known of their functions in Selaginella. Here, we isolated two 4CL genes (Sm4CL1 and Sm4CL2) from Selaginella moellendorffii. Based on the enzymatic activities of the recombinant proteins, both of these genes encoded bona fide 4CLs. The 4CL isoforms in S. moellendorffii have different activities: Sm4CL2 was more active than Sm4CL1. The enzymatic properties and gene expression patterns indicated that the 4CL genes have been conserved in the evolution of vascular plants.
Clozapine Use in First-Episode Psychosis: The Singapore Early Psychosis Intervention Programme (EPIP) Perspective.

OBJECTIVE Early symptomatic response is pertinent in improving outcomes in first-episode psychosis. One of the ways in which this may be achieved is by reducing inappropriate delays in clozapine initiation. This study aimed to examine clozapine prescribing practices among clinicians by establishing the prevalence of clozapine use, identifying baseline clinical and demographic factors that were associated with clozapine use, examining outcomes in clozapine users versus nonusers, and identifying inappropriate antipsychotic prescription patterns prior to clozapine initiation. METHODS A retrospective study including all consecutive patients who had presented to the Singapore Early Psychosis Intervention Programme (EPIP) from April 2001 to June 2012 was conducted. Clinical and demographic data were extracted from the EPIP database. Incident cases of clozapine users were identified, and additional treatment histories were obtained from medical records. In addition to descriptive statistics, multivariate analysis was performed to identify factors associated with clozapine initiation. RESULTS Data from 1,603 patients were available for baseline analyses. Of these, 69 patients (4.3%) had been prescribed clozapine. Having a younger age at onset, lack of employment, a lower Global Assessment of Functioning disability score, and a higher Positive and Negative Syndrome Scale total score at baseline were factors associated with clozapine use. After adjustment was made for confounders, clozapine users were found to have attained similar rates of remission and recovery as patients who did not use clozapine. Clozapine initiation was delayed by a mean of 19.3 weeks (SD = 27.1; range, 0-117). Prior to commencing clozapine, 29.4% of patients had received antipsychotic treatments above maximum limits, whereas 75% of patients were prescribed ≥ 3 different antipsychotics (median = 3; range, 2-7). CONCLUSIONS This study has confirmed that the prescribing of clozapine is low, delayed, and preceded by dosing of antipsychotic drugs above maximum limits. Identification of the factors found to be associated with clozapine use may encourage clinicians to consider clozapine sooner in relevant patients in hopes of achieving early symptomatic response.
Competencies for effective public health nutrition practice: a developing consensus

Abstract Objectives: To assess the level of consensus amongst an international panel of public health nutrition leaders regarding the essential competencies required for effective public health nutrition practice. Design: A modified Delphi study involving three rounds of questionnaires. Subjects: A panel of 20 public health nutrition experts from seven countries in the European Union, the USA and Australia. Results: Expert panellists completed three rounds of the study relating to competencies. A literature review conducted as a prelude to the expert panel survey identified common competency units from the fields of public health, health promotion, nutrition and dietetics, and health education. These were categorised into seven competency areas including analytical, socio-cultural and political, public health service, communication, management and leadership, nutrition science and professional competency categories. There was strong initial agreement (≥90% of panellists at Round 1) that developing internationally recognised competencies for public health nutrition specialists was a priority. Twenty-six of an initial listing of 52 competency units were rated as essential competencies by ≥80% of the panellists after Round 1. Iteration rounds resulted in the addition of five extra competency units suggested by panellists after Round 1 and an increase by 13 in the number of competencies rated as essential to consensus levels. From a total of 57 competency units rated after the final survey round, 41 competency units were rated as essential competencies by ≥80% of the panellists (consensus), with 21 of these unanimously rated as essential competencies. Conclusions: There is strong international agreement amongst public health nutrition leaders in Europe, the USA and Australia about a range of competencies required for effective public health nutrition practice. Essential competency units identified can be used to develop and review competency standards for public health nutrition.
Availability and Readability of Online Patient Education Materials Regarding Regional Anesthesia Techniques for Perioperative Pain Management

Objective Patient education materials (PEM) should be written at a sixth-grade reading level or lower. We evaluated the availability and readability of online PEM related to regional anesthesia and compared the readability and content of online PEM produced by fellowship and nonfellowship institutions. Methods With IRB exemption, we constructed a cohort of online regional anesthesia PEM by searching Websites from North American academic medical centers supporting a regional anesthesiology and acute pain medicine fellowships and used a standardized Internet search engine protocol to identify additional nonfellowship Websites with regional anesthesia PEM based on relevant keywords. Readability metrics were calculated from PEM using the TextStat 0.1. 4 textual analysis package for Python 2.7 and compared between institutions with and without a fellowship program. The presence of specific descriptive PEM elements related to regional anesthesia was also compared between groups. Results PEM from 17 fellowship and 15 nonfellowship institutions were included in analyses. The mean (SD) Flesch-Kincaid Grade Level for PEM from the fellowship group was 13.8 (2.9) vs 10.8 (2.0) for the nonfellowship group (p = 0.002). We observed no other differences in readability metrics between fellowship and nonfellowship institutions. Fellowship-based PEM less commonly included descriptions of the following risks: local anesthetic systemic toxicity (p = 0.033) and injury due to an insensate extremity (p = 0.003). Conclusions Available online PEM related to regional anesthesia are well above the recommended reading level. Further, fellowship-based PEM posted are at a higher reading level than PEM posted by nonfellowship institutions and are more likely to omit certain risk descriptions.
Delta 9-tetrahydrocannabinol: a novel treatment for experimental autoimmune encephalomyelitis.

Since multiple sclerosis (MS) is believed to be an immune-mediated disease, it follows that its therapies should be directed towards modulating the immune system. Current MS treatments, which include the use of exogenous steroids that are immunosuppressive, do not meet therapeutic objectives. delta 9-Tetrahydrocannabinol (THC), an active component of marijuana, has been shown to be immunosuppressive. To test THC's ability to suppress an immune-mediated disease, experimental autoimmune encephalomyelitis (EAE), the laboratory model of MS, was used. Lewis rats and strain 13 guinea pigs were administered THC either before inoculation for EAE or treated with THC after injection. Control animals received placebo. The effect of dose, in addition to the timing of treatment, was also investigated. All animals treated with placebo developed severe clinical EAE 10-12 days post-injection (d.p.i.) and more than 98% died by 15 d.p.i. THC-treated animals had either no clinical signs or mild signs with delayed onset (13-15 d.p.i.) with survival greater than 95%. Examination of central nervous system tissue revealed a marked reduction of inflammation in the THC-treated animals. Therefore, as THC has been shown to inhibit both clinical and histologic EAE, it may prove to be a new and relatively innocuous agent for the treatment of immune-mediated diseases.
An efficient optimization approach for packet-wise DF and incremental DF relaying for uplink CDMA communications

In this paper, we define a multi-access interference (MAI) cost that can assess the extra interference, inherent to relaying use and perceived by the whole cellular network. This MAI cost shadows an implicit and smart power control for CDMA uplink communications. In fact, this cost takes into account not only the reception quality required at the serving base station but also the global interference generated to all others base stations in the cellular system. Here, the optimization goal aims to enhance the system performance, in terms of Packet-Error-Rate (PER), for a required quality of service (QoS). The optimization approach is achieved for both Decode-and-Forward (DF) and Incremental DF relaying schemes, carried out on packet-by-packet basis. A variety of simulation results are obtained using the analytical expressions of Packet-Error-Probability (PEP) that we derive for both DF and IDF schemes. By way of an example, for a target PER of 10-2, our optimized IDF scheme could afford more than 13 dB gain, in terms of MAI cost reduction, over the direct transmission scheme. Furthermore, simulation results underline that the optimized IDF relaying is more powerful than the optimized DF scheme and provides as much as 3 dB gain for some relay positions.
Biodiversity of strongylids (Nematoda: Strongylidae) communities in domestic horses from Poland and Ukraine

SummaryExamination of the biodiversity of horse strongylid communities was performed on 51 domestic horses from Southern Poland and Western Ukraine by in vivo method. All horses were dewormed with macrocyclic lactone anthelmintics. Strongylids (34,715 specimens) were collected and identified by morphological criteria. In Poland, 25 strongylid species were found. Five cyathostome species dominated in the community. Large strongyles were found in 23.1 % of horses and composed 0.56 % of total strongylid number. General structure of strongylid community was multimodal with dominant, subdominant, background and rare species. In Ukraine, 19 species were found. Five cyathostome species dominated in the community. Strongylinae were found in 17.4 % of horses and composed 0.07% of community. General structures of strongylid community were multimodal or bimodal depends on type of horse keeping conditions. Regularity of anthelmintic treatment was found to be more influential on strongylid community structure than differences in horse-keeping conditions at the both countries.
Automated Landslides Detection for Mountain Cities Using Multi-Temporal Remote Sensing Imagery

Landslides that take place in mountain cities tend to cause huge casualties and economic losses, and a precise survey of landslide areas is a critical task for disaster emergency. However, because of the complicated appearance of the nature, it is difficult to find a spatial regularity that only relates to landslides, thus landslides detection based on only spatial information or artificial features usually performs poorly. In this paper, an automated landslides detection approach that is aiming at mountain cities has been proposed based on pre- and post-event remote sensing images, it mainly utilizes the knowledge of landslide-related surface covering changes, and makes full use of the temporal and spatial information. A change detection method using Deep Convolution Neural Network (DCNN) was introduced to extract the areas where drastic alterations have taken place; then, focusing on the changed areas, the Spatial Temporal Context Learning (STCL) was conducted to identify the landslides areas; finally, we use slope degree which is derived from digital elevation model (DEM) to make the result more reliable, and the change of DEM is used for making the detected areas more complete. The approach was applied to detecting the landslides in Shenzhen, Zhouqu County and Beichuan County in China, and a quantitative accuracy assessment has been taken. The assessment indicates that this approach can guarantee less commission error of landslide areal extent which is below 17.6% and achieves a quality percentage above 61.1%, and for landslide areas, the detection percentage is also competitive, the experimental results proves the feasibility and accuracy of the proposed approach for the detection landslides in mountain cities.