Miracle-dz/UniFAR-FTUs huggingface dataset:
The incidence of deep venous thrombosis in high-risk Indian neurosurgical patients: Need for early chemoprophylaxis?

Introduction: Deep venous thrombosis (DVT) is thought to be less common in Asians than in Caucasian population. The incidence of DVT in high-risk groups, especially the neurosurgical (NS) patients, has not been well studied. This leaves no firm basis for the start of early prophylactic anticoagulation within first 5 postoperative days in Indian NS patients. This is a prospective observational study to determine the early occurrence of DVT in the NS patients. Patients and Methods: We screened 137 consecutive high-risk NS patients based on inclusion and exclusion criteria. The femoral veins were screened using Doppler ultrasound on day 1, 3, and 5 of admission into the NS Intensive Care Unit (ICU) at tertiary center from South India. Results: Among 2887 admissions to NICU 147 patients met inclusion criteria. One hundred thirty seven were screened for DVT. There was a 4.3% (6/137) incidence of DVT with none of the six patients having signs or symptoms of pulmonary embolism. Among the risk factors studied, there was a significant association with femoral catheterization and a probable association with weakness/paraparesis/paraplegia. The mortality in the study group was 10.8% with none attributable to DVT or pulmonary embolism. Conclusion: There is a low incidence of DVT among the high risk neurosurgical population evaluated within the first 5 days of admission to NICU, limiting the need for early chemical thrombo-prophylaxis in these patients. With strict protocols for mechanical prophylaxis with passive leg exercise, early mobilization and serial femoral Doppler screening, heparin anticoagulation can be restricted within the first 5 days of ICU admission in high risk patients.
Relación entre actividad física y consumo de alcohol, tabaco y otras sustancias perjudiciales para la salud en alumnos de ESO del municipio de Avilés

This study was designed to analyze the consumption of tobacco, alcohol and other health-harmful substances, as well as its relationship to daily physical activity and sport practice habits in a representative sample of secondary education students from Aviles. Both tobacco and alcohol consumption start at 13 years. Percentage of sporadic or frequent smokers is clearly higher among girls and there are no gender differences in alcohol consunmption. Cannabis consupmtion develops at 14 years and a third of subjects have consumed by 15 years. The next more frequently used illegal substances are stimulating pills. When individuals are classified attending to their daily physical activity, expressed in kilocalories per kilogram and day, although only a 4% are considered as very inactive, 51% of the total are out of the active categories. Mean physical activity of groups with a high consumption of tobacco, alcohol or cannabis is more elevated than those from subjects with a low consumption. There is a tendency to the decrease of tobacco and alcohol consumption when time dedicated to sport practice increases. KEY WORDS: physical activity, tobacco, alcohol, drugs
The Characterisation of Human Body Influence on Indoor 3.5 GHz Path Loss Measurement

This paper investigates the influence of the human body on indoor measurements of radio wave path loss at 3.5 GHz and proposes a solution to improve the accuracy of measurement. The presence of the human body causes measurement errors to radio wave field strength, which is of concern for analysis. The reduction of errors due to measurement process enhances the accuracy of measurement data that is used to validate propagation models. Also, the characterisation of signal strengths at nearby-locations will be presented, which may be used as a proof to develop new propagation models that take advantage of fast calculation based on the observation of relations between geographically-related signal levels. This is also used to analyse the human body influence depending on the locations.
A systematic review on the effects of local antimicrobials as adjuncts to subgingival debridement, compared with subgingival debridement alone, in the treatment of chronic periodontitis.

AIMS To update the existing scientific evidence on the efficacy of local antimicrobials as adjuncts to subgingival debridement in the treatment of chronic periodontitis. MATERIAL AND METHODS Fifty-six papers were selected, reporting data from 52 different investigations. All the studies reported changes in probing pocket depth (PPD) and clinical attachment level (CAL) and most in plaque index (PlI) and/or bleeding on probing (BOP). Meta-analyses were performed with the data retrieved from the studies fulfilling the inclusion criteria. RESULTS The overall effect of the subgingival application of antimicrobials was statistically significant (p = 0.000) for both changes in PPD and CAL with a weighted mean difference (WMD) of -0.407 and -0.310 mm respectively. No significant differences occurred for changes in BOP and PlI. Subgingival application of tetracycline fibres, sustained released doxycycline and minocycline demonstrated a significant benefit in PPD reduction (WMD between 0.5 and 0.7 mm). The rest of the tested outcomes demonstrated a high heterogeneity. The local application of chlorhexidine and metronidazole showed a minimal effect when compared with placebo (WMD between 0.1 and 0.4 mm). CONCLUSIONS The scientific evidence supports the adjunctive use of local antimicrobials to debridement in deep or recurrent periodontal sites, mostly when using vehicles with proven sustained release of the antimicrobial.
Heat Shock Factor 1 Contributes to Ischemia-Induced Angiogenesis by Regulating the Mobilization and Recruitment of Bone Marrow Stem/Progenitor Cells

Bone marrow (BM)-derived stem/progenitor cells play an important role in ischemia-induced angiogenesis in cardiovascular diseases. Heat shock factor 1 (HSF1) is known to be induced in response to hypoxia and ischemia. We examined whether HSF1 contributes to ischemia-induced angiogenesis through the mobilization and recruitment of BM-derived stem/progenitor cells using HSF1-knockout (KO) mice. After the induction of ischemia, blood flow and microvessel density in the ischemic hindlimb were significantly lower in the HSF1-KO mice than in the wild-type (WT) mice. The mobilization of BM-derived Sca-1- and c-kit-positive cells in peripheral blood after ischemia was significantly lower in the HSF1-KO mice than in the WT mice. BM stem/progenitor cells from HSF1-KO mice showed a significant decrease in their recruitment to ischemic tissue and in migration, adhesion, and survival when compared with WT mice. Blood flow recovery in the ischemic hindlimb significantly decreased in WT mice receiving BM reconstitution with donor cells from HSF1-KO mice. Conversely, blood flow recovery in the ischemic hindlimb significantly increased in HSF1-KO mice receiving BM reconstitution with donor cells from WT mice. These findings suggest that HSF1 contributes to ischemia-induced angiogenesis by regulating the mobilization and recruitment of BM-derived stem/progenitor cells.
Co-Teaching: Getting to Know Your Partner

getting to know one another. They were in a new co-teaching partnership, designed by the school administrator, since just before the school year began. Mr. Salvatore had been a solo fourthgrade teacher for 15 years. He enjoyed teaching and maintaining complete instructional responsibility for students in his classes. Ms. Happa was new to the school. She had been a teacher for 7 years and enjoyed collegial interactions on behalf of students for whom she and other teachers shared responsibility. In the beginning of their teaching arrangement, Ms. Happa was comfortable in a supportive role because she wanted to learn about the students and Mr. Salvatore’s teaching style. As time passed, however, she wanted a more active instructional role and increased opportunities to interact with students, especially in the upcoming implementation of response to intervention (RTI). Co-teaching is analogous to a professional marriage (Scruggs, Mastropieri, & McDuffie, 2007) in which teaching partners collaborate to provide instructional services to students with disabilities and others at risk of school failure as a result of the negative consequences of environmental events. Regrettably, in many instances coteachers are carelessly placed together and therefore, completely miss out on the development stages critical in a relationship. As in conventional marriage, skipping the time to develop a strong relationship may lead to communication problems and misunderstandings, as well as ending the relationship. These difficulties between adults can negatively affect students in co-teaching settings. For example, students may receive conflicting messages when there is friction in a co-teaching relationship and the teachers are not synchronizing classroom logistics or lesson design and delivery. The situation may be especially complex for students with information-processing difficulties. As a result, they may not know which direction to follow or which teacher to ask for assistance. Another consequence, often called “staff splitting,” may occur when teachers do not get along: the old game of “he said, she said. ” Always savvy students can read an uncomfortable and tense relationship and may use a rift between teachers to manipulate a situation to their advantage. Here, of course, as in many families, one teacher says no to a request but the other teacher may say yes. The process of staff splitting may increase friction between the co-teachers. Thus, like parents, teachers must communicate with each other and ensure they are on the same page regarding interactions with children. Effective communication is key to navigating professional relationships, whether teachers are thrown together or have time to get to know each other. The important consideration, as with family life and parents who have
Genetic Modification of Carbon Catabolite Repression in Trichoderma reesei for Improved Protein Production

ABSTRACT The cellulase and hemicellulase genes of the filamentous fungus Trichoderma reesei have been shown to be under carbon catabolite repression mediated by the regulatory gene cre1. In this study, strains were constructed in which the cre1 gene was either completely removed or replaced by a truncated mutant variant, cre1-1, found previously in the Rut-C30 mutant strain with enhanced enzyme production capability. The T. reesei transformants with either deletion or truncation of cre1 had clearly altered colony morphology compared with the parental strains, forming smaller colonies and fewer aerial hyphae and spores. Liquid cultures in a medium with glucose as a carbon source showed that the transformants were derepressed in cellulase and hemicellulase production. Interestingly, they also produced significantly elevated levels of these hydrolytic enzymes in fermentations carried out in a medium inducing the hydrolase genes. This suggests that cre1 acts as a modulator of cellulase and hemicellulase gene expression under both noninducing and inducing conditions. There was no phenotypic difference between the Δcre1 and cre1-1 mutant strains in any of the experiments done, indicating that the cre1-1 gene is practically a null allele. The results of this work indicate that cre1 is a valid target gene in strain engineering for improved enzyme production in T. reesei.
Prenatal and Post-natal Exposure to Antibiotics and Risk of Asthma in Childhood

J Metsala, A Lundqvist, L Virta, M Kaila, S Virtanen. J Clin Exp Allergy. 2014;45(1):137–145 The purpose of this study was to explore associations between prenatal and postnatal exposure to antibiotics and the risk of childhood asthma. All children born in Finland between 1996 and 2004 and diagnosed with asthma and 1 matched control per case were identified from 4 national health registries (Drug Prescription Register, Special Reimbursement Register, Population Register, and Medical Birth Register), resulting in 6690 case-control pairs. Prenatal exposure to antibiotics was identified by extracting purchasing history of all antibiotics (ATC Code J01—antibiotics for systemic use) by the mother during pregnancy from …
An artificial neural minimum-variance estimator

Results are presented of a study into one aspect of the application of artificial neural nets to the continuous working mode. For the proposed configuration, the authors give sufficient conditions for the existence and uniqueness of the steady-state solution. They show the feasibility of the choice of the proposed recurrent net for solving a quadratic programming problem using an analog working mode. The authors validate the theory for minimum-variance deconvolution. <<ETX>>
Shading-based dynamic shape refinement from multi-view video under general illumination

We present an approach to add true fine-scale spatio-temporal shape detail to dynamic scene geometry captured from multi-view video footage. Our approach exploits shading information to recover the millimeter-scale surface structure, but in contrast to related approaches succeeds under general unconstrained lighting conditions. Our method starts off from a set of multi-view video frames and an initial series of reconstructed coarse 3D meshes that lack any surface detail. In a spatio-temporal maximum a posteriori probability (MAP) inference framework, our approach first estimates the incident illumination and the spatially-varying albedo map on the mesh surface for every time instant. Thereafter, albedo and illumination are used to estimate the true geometric detail visible in the images and add it to the coarse reconstructions. The MAP framework uses weak temporal priors on lighting, albedo and geometry which improve reconstruction quality yet allow for temporal variations in the data.
Modeling the Geographic Distribution of Ixodes scapularis and Ixodes pacificus (Acari: Ixodidae) in the Contiguous United States

Abstract In addition to serving as vectors of several other human pathogens, the black-legged tick, Ixodes scapularis Say, and western black-legged tick, Ixodes pacificus Cooley and Kohls, are the primary vectors of the spirochete (Borrelia burgdorferi) that causes Lyme disease, the most common vector-borne disease in the United States. Over the past two decades, the geographic range of I. pacificus has changed modestly while, in contrast, the I. scapularis range has expanded substantially, which likely contributes to the concurrent expansion in the distribution of human Lyme disease cases in the Northeastern, North-Central and Mid-Atlantic states. Identifying counties that contain suitable habitat for these ticks that have not yet reported established vector populations can aid in targeting limited vector surveillance resources to areas where tick invasion and potential human risk are likely to occur. We used county-level vector distribution information and ensemble modeling to map the potential distribution of I. scapularis and I. pacificus in the contiguous United States as a function of climate, elevation, and forest cover. Results show that I. pacificus is currently present within much of the range classified by our model as suitable for establishment. In contrast, environmental conditions are suitable for I. scapularis to continue expanding its range into northwestern Minnesota, central and northern Michigan, within the Ohio River Valley, and inland from the southeastern and Gulf coasts. Overall, our ensemble models show suitable habitat for I. scapularis in 441 eastern counties and for I. pacificus in 11 western counties where surveillance records have not yet supported classification of the counties as established.
A Case Study of High-Velocity, Persistent Geotropic Nystagmus: Is This BPPV?

BACKGROUND AND PURPOSE Deciphering the cause for a persistent, direction-changing geotropic nystagmus can be difficult. Migraine and light cupula are two possible causes, though can be confused with benign paroxysmal positional vertigo (BPPV) affecting the horizontal semicircular canal. In migraine, the persistent geotropic nystagmus tends to be slow; in light cupula, the nystagmus has been illustrated to beat in the direction opposite that of prone positioning. CASE DESCRIPTION Here we describe a patient with initial occurrence then recurrence of a high velocity (≥30 deg/sec), persistent direction-changing geotropic nystagmus and vertigo with an intensity variable based on head position, which was difficult to manage. This patient did not have migraine. The case presented uniquely as it was unlikely due to canalithiasis of the horizontal semicircular canal yet the presentation was not clearly related to the light cupula phenomena either. INTERVENTION In this case, the physical therapist attempted to use the barbeque roll canalith repositioning maneuver (CRM) even though the direction-changing geotropic nystagmus was persistent. The nystagmus did not resolve during the clinic visit. OUTCOMES AND DISCUSSION The persistent, high velocity geotropic nystagmus resolved within 1 week, however, this resolution was likely spontaneous and not due to the CRM intervention. Our case suggests that physical therapists assessing persistent geotropic nystagmus should wait long enough for the nystagmus to stop (∼2 minutes), test for fatigue by repeating the positional nystagmus tests, incorporate a head flexion component as part of the positional testing, and attempt to identify a null point.Video Abstract available for additional insights from the authors (see Video, Supplemental Digital Content 1, http://links.lww.com/JNPT/A178).
Providing declarative semantics for HH extended constraint logic programs

This paper is focused on a double extension of traditional Logic Programming which enhances it following two different approaches. On one hand, extending Horn logic to hereditary Harrop formulas HH), in order to improve the expressive power; on the other, incorporating constraints, in order to increase the efficiency. For this combination, called HH(C), an operational semantics exists, but no declarative semantic for it has been defined so far.One of the main features of (Constraint) Logic Programming is that the algorithmic behavior of (constraint) logic programs and its mathematical interpretations agree with each other, in the sense that the declarative meaning of a program can be interpreted operationally as a goal-oriented search for solutions. Both operational (algorithmic) and declarative (mathematical) semantics for programs are useful and widely developed in the frame of Logic Programming as well as in its extension, Constraint Logic Programming.For these reasons, HH(C) was in need of a more mathematical interpretation of programs. In this paper some fixed point semantics for HH(C) are presented. Taking as a starting point the techniques used by Miller to interpret the fragment of HH that incorporates intuitionistic implication in goals, we have formulated two novel extensions capable of dealing with the whole HH logic, including universal quantifiers, as well as with the presence of constraints. Those semantics are proved to be sound and complete w.r. t. the operational semantics of HH(C).
Spectral Sparsification and Regret Minimization Beyond Matrix Multiplicative Updates

In this paper, we provide a novel construction of the linear-sized spectral sparsifiers of Batson, Spielman and Srivastava [11]. While previous constructions required Ω(n4) running time [11, 45], our sparsification routine can be implemented in almost-quadratic running time O(n2+ε). The fundamental conceptual novelty of our work is the leveraging of a strong connection between sparsification and a regret minimization problem over density matrices. This connection was known to provide an interpretation of the randomized sparsifiers of Spielman and Srivastava [39] via the application of matrix multiplicative weight updates (MWU) [17, 43]. In this paper, we explain how matrix MWU naturally arises as an instance of the Follow-the-Regularized-Leader framework and generalize this approach to yield a larger class of updates. This new class allows us to accelerate the construction of linear-sized spectral sparsifiers, and give novel insights on the motivation behind Batson, Spielman and Srivastava [11].
Body dissatisfaction: can a short media literacy message reduce negative media exposure effects amongst adolescent girls?

OBJECTIVES This experimental study examined whether a brief video intervention identifying the artificial nature of media images could protect adolescent girls from negative media exposure effects and body dissatisfaction. DESIGN A 2 (intervention condition)×2 (exposure condition) between-groups design was used. METHODS Participants were 127 British girls aged between 10 and 13 recruited from two secondary schools. Girls were assigned to one of four experimental conditions. An intervention video was shown to half of the girls immediately before they viewed ultra-thin models or control images. The video was developed by Dove's Self-Esteem Fund and has the benefits of being professionally produced and freely available through the Internet. RESULTS In the absence of the intervention video, viewing thin idealized models was associated with lower state body satisfaction and lower state body esteem than exposure to control images. However, viewing the video intervention immediately before exposure prevented this negative exposure effect. CONCLUSION The results suggest that, in the short term, this widely available video prevents girls from making damaging social comparisons with media models. Although this study only examined short-term effects, the findings add to the growing evidence that media literacy interventions may be useful tools in protecting young girls from body dissatisfaction.
Predicting fruit fly’s sensing rate with insect flight simulations

Significance To balance in air, insects not only need to generate enough lift, but also have to make subtle adjustments to their wing movement to stabilize themselves. The tiny changes during complex wing movement, together with the intricacy of the underlying neural feedback system, make it extremely difficult to observe the key changes and to tease out the internal control algorithms insects use to stabilize themselves. With computational simulations and analyses, we can now make predictions about how fast and how frequently a model insect must sense and act to stabilize itself. Our results offer a strategy for effective stabilization of flapping flight and lead us to conjecture that fruit flies sense their kinematic state every wing beat. Without sensory feedback, flies cannot fly. Exactly how various feedback controls work in insects is a complex puzzle to solve. What do insects measure to stabilize their flight? How often and how fast must insects adjust their wings to remain stable? To gain insights into algorithms used by insects to control their dynamic instability, we develop a simulation tool to study free flight. To stabilize flight, we construct a control algorithm that modulates wing motion based on discrete measurements of the body-pitch orientation. Our simulations give theoretical bounds on both the sensing rate and the delay time between sensing and actuation. Interpreting our findings together with experimental results on fruit flies’ reaction time and sensory motor reflexes, we conjecture that fruit flies sense their kinematic states every wing beat to stabilize their flight. We further propose a candidate for such a control involving the fly’s haltere and first basalar motor neuron. Although we focus on fruit flies as a case study, the framework for our simulation and discrete control algorithms is applicable to studies of both natural and man-made fliers.