Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors Influencing Lodgepole Pine Cone Openness

1. Lodgepole pine cone serotiny is commonly thought to be an adaptation to fire dominated ecosystems. 2. This study tested the hypothesis that lodgepole pine cone openness can be influenced by incident solar radiation and tree age. 3. Two approximations of solar radiation (aspect and distance to nearest neighboring tree canopy) were used. 4. Tree age was approximated by tree diameter. 5. Cone angle of attachment was also tested. 6. There was a statistically significant difference (p<0.05) between cones on the north and south facing sides of the trees. Synthesis: Results support the hypothesis that incident solar radiation influences cone openness. This study serves as a model for future studies that could investigate cone serotiny and the effects of incident radiation on cone openness in surrounding areas. Such information taken together with local disturbance history would increase understanding of the interplay between environmental factors and genetic predisposition for serotiny.
Occupational transmission of an Orthopoxvirus infection during an outbreak in a colony of Macaca tonkeana in Lazio Region, Italy, 2015

Orthopoxviruses spill over from animal reservoirs to accidental hosts, sometimes causing human infections. We describe the surveillance and infection control measures undertaken during an outbreak due to an Orthopoxvirus occurred in January 2015 in a colony of Macaca tonkeana in the province of Rieti, Latio, Italy, which caused a human asymptomatic infection. According to the epidemiological investigation, the human transmission occurred after an unprotected exposure. The contacts among wild, captive and domestic animals and humans, together with decreased immunity against Orthopoxviruses in the community, may put animal handlers at risk of infection, especially after the cessation of smallpox vaccination. To reduce these threats, standard precautions including respiratory hygiene and transmission‐based precautions should be carefully applied also in veterinary medicine.
Low Savings Rates in the Economic Community of West African States (Ecowas): The Role of the Political Instability-Income Interaction

Abstract This paper employs PCSE, OLS and TSLS with random effects to investigate the impact of the political instabilityincome interaction on savings in ECOWAS countries during the period 1996-2012. The empirical evidence illustrates that higher political stability is associated with higher savings and income levels moderate the adverse effect of political instability on savings, indicating that the impact of political instability on savings is higher in low income ECOWAS countries, but lesser at higher levels of income. The paper recommends the promotion of political stability via increases in incomes to raise savings in the ECOWAS region.
Reliability-analysis on damage of unidirectional composites matrix polymers

This work presents an analytical model to predict the strength of the unidirectional carbon epoxy composite using micromechanical techniques. This model supposes that a group of broken fibres surrounded by a number of intact fibres with hexagonal arrangement. The mathematical developments used are presented to justify the distribution form of the stresses around broken fibre and adjacent intact fibres. To follow the evolution of the damage in regions of debonding and local plasticity; we proceeded to a progressive increase in the fiber volume fraction and tensile external load. This, procedure enable us to evaluate the extension of the region locally plasticized, the ineffective region, the stress concentration and the longitudinal displacement of broken and intact fibres, in function of broken fibres number and specimen length. As fiber breaks are intrinsically random, the variability of input data allows us to describe the probabilistic model by using the Monte-Carlo method. The sensitivities of the mechanical response are evaluated regarding the uncertainties in design variables such as Young’s modulus of fibers and matrix, fiber reference strength, shear yield stress, fiber volume fraction and shear parameter defining the shear stress in the inelastic region.
Evidence-Based Psychosocial Treatments for Adolescent Substance Abuse

This review synthesized findings from 17 studies since 1998 regarding evaluation of outpatient treatments for adolescent substance abuse. These studies represented systematic design advances in adolescent clinical trial science. The research examined 46 different intervention conditions with a total sample of 2,307 adolescents. The sample included 7 individual cognitive behavior therapy (CBT) replications (n = 367), 13 group CBT replications (n = 771), 17 family therapy replications (n = 850) and 9 minimal treatment control conditions (n = 319). The total sample was composed of approximately 75% males, and the ethnic/racial distribution was approximately 45% White, 25% Hispanic, 25% African American, and 5% other groups. Meta-analysis was used to evaluate within-group effect sizes as well as differences between active treatment conditions and the minimal treatment control conditions. Methodological rigor of studies was classified using Nathan and Gorman (2002) criteria, and treatments were classified using criteria for well-established and probably efficacious interventions based on Chambless et al. (1996). Three treatment approaches, multidimensional family therapy, functional family therapy, and group CBT emerged as well-established models for substance abuse treatment. However, a number of other models are probably efficacious, and none of the treatment approaches appeared to be clearly superior to any others in terms of treatment effectiveness for adolescent substance abuse.
Symbolic use of marine shells and mineral pigments by Iberian Neandertals 115,000 years ago

U-Th dating of archaeological deposits of Cueva de los Aviones provides evidence for Neandertal symbolism 115,000 years ago. Cueva de los Aviones (southeast Spain) is a site of the Neandertal-associated Middle Paleolithic of Europe. It has yielded ochred and perforated marine shells, red and yellow colorants, and shell containers that feature residues of complex pigmentatious mixtures. Similar finds from the Middle Stone Age of South Africa have been widely accepted as archaeological proxies for symbolic behavior. U-series dating of the flowstone capping the Cueva de los Aviones deposit shows that the symbolic finds made therein are 115,000 to 120,000 years old and predate the earliest known comparable evidence associated with modern humans by 20,000 to 40,000 years. Given our findings, it is possible that the roots of symbolic material culture may be found among the common ancestor of Neandertals and modern humans, more than half-a-million years ago.
Optimal Forecasting of Noncausal Autoregressive Time Series

In this paper, we propose a simulation-based method for computing point and density forecasts for univariate noncausal and non-Gaussian autoregressive processes. Numerical methods are needed for forecasting such time series because the prediction problem is generally nonlinear and therefore no analytic solution is available. According to a limited simulation experiment, the use of a correct noncausal model can lead to substantial gains in forecast accuracy over the corresponding causal model. An empirical application to US inflation demonstrates the importance of allowing for noncausality in improving point and density forecasts.
COPD as an endothelial disorder: endothelial injury linking lesions in the lungs and other organs? (2017 Grover Conference Series)

Chronic obstructive pulmonary disease (COPD) is characterized by chronic expiratory airflow obstruction that is not fully reversible. COPD patients develop varying degrees of emphysema, small and large airway disease, and various co-morbidities. It has not been clear whether these co-morbidities share common underlying pathogenic processes with the pulmonary lesions. Early research into the pathogenesis of COPD focused on the contributions of injury to the extracellular matrix and pulmonary epithelial cells. More recently, cigarette smoke-induced endothelial dysfunction/injury have been linked to the pulmonary lesions in COPD (especially emphysema) and systemic co-morbidities including atherosclerosis, pulmonary hypertension, and chronic renal injury. Herein, we review the evidence linking endothelial injury to COPD, and the pathways underlying endothelial injury and the “vascular COPD phenotype” including: (1) direct toxic effects of cigarette smoke on endothelial cells; (2) generation of auto-antibodies directed against endothelial cells; (3) vascular inflammation; (4) increased oxidative stress levels in vessels inducing increases in lipid peroxidation and increased activation of the receptor for advanced glycation end-products (RAGE); (5) reduced activation of the anti-oxidant pathways in endothelial cells; (6) increased endothelial cell release of mediators with vasoconstrictor, pro-inflammatory, and remodeling activities (endothelin-1) and reduced endothelial cell expression of mediators that promote vasodilation and homeostasis of endothelial cells (nitric oxide synthase and prostacyclin); and (7) increased endoplasmic reticular stress and the unfolded protein response in endothelial cells. We also review the literature on studies of drugs that inhibit RAGE signaling in other diseases (angiotensin-converting enzyme inhibitors and angiotensin receptor blockers), or vasodilators developed for idiopathic pulmonary arterial hypertension that have been tested on cell culture systems, animal models of COPD, and/or smokers and COPD patients.
Towards Interpreting Robotic System for Fingerspelling Recognition in Real Time

Hearing-impaired communities around the world communicate via a sign language. The focus of this work is to develop an interpreting human-robot interaction system that could act as a sign language interpreter in public places. This paper presents an ongoing work, which aims to recognize fingerspelling gestures in real time. To this end, we utilize a deep learning method for classification of 33 gestures used for fingerspelling by the local deaf-mute community. In order to train and test the performance of the recognition system, we utilize previously collected dataset of motion RGB-D data of 33 manual gestures. After applying it to a deep learning method, we achieved an offline result of an average accuracy of 75% for a complete alphabet recognition. In real time, the result was only 24.72%. In addition, we integrated a form of auto-correction in order to perform spell-checking on the recognized letters. Among 35 tested words, four words were recognized correctly (11.4%). Finally, we conducted an exploratory study inviting ten deaf individuals to interact with our sign language interpreting robotic system.
Portrait of a Privacy Invasion Detecting Relationships Through Large-scale Photo Analysis

The popularity of online social networks has changed the way in which we share personal thoughts, political views, and pictures. Pictures have a particular important role in the privacy of users, as they can convey substantial information (e.g., a person was attending an event, or has met with another person). Moreover, because of the nature of social networks, it has become increasingly difficult to control who has access to which content. Therefore, when a substantial amount of pictures are accessible to one party, there is a very serious potential for violations of the privacy of users. In this paper, we demonstrate a novel technique that, given a large corpus of pictures shared on a social network, automatically determines who is dating whom, with reasonable precision. More specifically, our approach combines facial recognition, spatial analysis, and machine learning techniques to determine pairs that are dating. To the best of our knowledge, this is the first privacy attack of this kind performed on social networks. We implemented our approach in a tool, called Creepic, and evaluated it on two real-world datasets. The results show that it is possible to automatically extract non-obvious, and non-disclosed, relationships between people represented in a group of pictures, even when the people involved are not directly part of a connected social clique.
Automation bias and verification complexity: a systematic review

Introduction: While potentially reducing decision errors, decision support systems can introduce new types of errors. Automation bias (AB) happens when users become overreliant on decision support, which reduces vigilance in information seeking and processing. Most research originates from the human factors literature, where the prevailing view is that AB occurs only in multitasking environments. Objectives: This review seeks to compare the human factors and health care literature, focusing on the apparent association of AB with multitasking and task complexity. Data sources: EMBASE, Medline, Compendex, Inspec, IEEE Xplore, Scopus, Web of Science, PsycINFO, and Business Source Premiere from 1983 to 2015. Study selection: Evaluation studies where task execution was assisted by automation and resulted in errors were included. Participants needed to be able to verify automation correctness and perform the task manually. Methods: Tasks were identified and grouped. Task and automation type and presence of multitasking were noted. Each task was rated for its verification complexity. Results: Of 890 papers identified, 40 met the inclusion criteria; 6 were in health care. Contrary to the prevailing human factors view, AB was found in single tasks, typically involving diagnosis rather than monitoring, and with high verification complexity. Limitations: The literature is fragmented, with large discrepancies in how AB is reported. Few studies reported the statistical significance of AB compared to a control condition. Conclusion: AB appears to be associated with the degree of cognitive load experienced in decision tasks, and appears to not be uniquely associated with multitasking. Strategies to minimize AB might focus on cognitive load reduction.
The Role of Reactive Oxygen Species in Regulating T Cell-mediated Immunity and Disease

T lymphocytes rely on several metabolic processes to produce the high amounts of energy and metabolites needed to drive clonal expansion and the development of effector functions. However, many of these pathways result in the production of reactive oxygen species (ROS), which have canonically been thought of as cytotoxic agents due to their ability to damage DNA and other subcellular structures. Interestingly, ROS has recently emerged as a critical second messenger for T cell receptor signaling and T cell activation, but the sensitivity of different T cell subsets to ROS varies. Therefore, the tight regulation of ROS production by cellular antioxidant pathways is critical to maintaining proper signal transduction without compromising the integrity of the cell. This review intends to detail the common metabolic sources of intracellular ROS and the mechanisms by which ROS contributes to the development of T cell-mediated immunity. The regulation of ROS levels by the glutathione pathway and the Nrf2-Keap1-Cul3 trimeric complex will be discussed. Finally, T cell-mediated autoimmune diseases exacerbated by defects in ROS regulation will be further examined in order to identify potential therapeutic interventions for these disorders.
Loss of SMAD4 Promotes Lung Metastasis of Colorectal Cancer by Accumulation of CCR1+ Tumor-Associated Neutrophils through CCL15-CCR1 Axis

Purpose: We have reported loss of SMAD4 promotes expression of CCL15 from colorectal cancer to recruit CCR1+ myeloid cells through the CCL15-CCR1 axis, which contributes to invasion and liver metastasis. However, the molecular mechanism of lung metastasis is yet to be elucidated. Our purpose is to determine whether similar mechanism is involved in the lung metastasis of colorectal cancer. Experimental Design: In a mouse model, we examined whether SMAD4 could affect the metastatic activity of colorectal cancer cells to the lung through the CCL15-CCR1 axis. We immunohistochemically analyzed expression of SMAD4, CCL15, and CCR1 with 107 clinical specimens of colorectal cancer lung metastases. We also characterized the CCR1+ myeloid cells using several cell-type–specific markers. Results: In a mouse model, CCL15 secreted from SMAD4-deficient colorectal cancer cells recruited CCR1+ cells, promoting their metastatic activities to the lung. Immunohistochemical analysis of lung metastases from colorectal cancer patients revealed that CCL15 expression was significantly correlated with loss of SMAD4, and that CCL15-positive metastases recruited approximately 1.9 times more numbers of CCR1+ cells than CCL15-negative metastases. Importantly, patients with CCL15-positive metastases showed a significantly shorter relapse-free survival (RFS) than those with CCL15-negative metastases, and multivariate analysis indicated that CCL15 expression was an independent predictor of shorter RFS. Immunofluorescent staining showed that most CCR1+ cells around lung metastases were tumor-associated neutrophil, although a minor fraction was granulocytic myeloid-derived suppressor cell. Conclusions: CCL15-CCR1 axis may be a therapeutic target to prevent colorectal cancer lung metastasis. CCL15 can be a biomarker indicating poor prognosis of colorectal cancer patients with lung metastases. Clin Cancer Res; 23(3); 833–44. ©2016 AACR.
Obesity Impairs Oligopeptide/Amino Acid‐Induced Ghrelin Release and Smooth Muscle Contractions in the Human Proximal Stomach

SCOPE The satiation properties of proteins involve effects on gut peptide release and gastrointestinal motility which may be altered during obesity. This study compares the in vitro response and role of amino acid (AA) taste receptors (TASR) in the effect of AAs and a casein hydrolysate on ghrelin release and smooth muscle (SM) contractions in the proximal gut of lean and obese patients. METHODS AND RESULTS Basal ghrelin release, measured from mucosal segments, is maximal in the fundus and decreased distally. Obesity selectively impaires the stimulatory effect of a casein hydrolyaste on ghrelin release in the fundus but does not affect its inhibitory effect in the small intestine (SI). The SM contractions induced by a casein hydrolysate and AAs are stronger in strips from the SI than from the fundus but are reduced in the stomach of obese patients. The region-dependent expression of AA-TASRs in the mucosa and SM layer is affected by obesity. Most of the AA-induced responses are reduced by the umami antagonist, lactisole. l-Met-induced responses involve bitter taste receptors. CONCLUSION Region-specific targeting of AA taste receptors on both enteroendocrine and SM cells with specific AA-enriched diets might be a useful strategy to combat obesity as well as hypomotility disorders.
Reliability of PCB Solder Joints Assembled with SACm™ Solder Paste

The solder alloy SACm™0510 has been reported to be a superior alloy when used as BGA balls, exhibiting not only an outstanding drop test performance when compared to SAC105, but also as having high thermal fatigue reliability when compared to high Ag SAC solders. In this study, SACm0510 solder was evaluated as a solder paste. The voiding behavior of SGA solder joints was comparable for SACm0510, SAC105, and SC305. When evaluating SGA assemblies on a customized drop test, SACm0510 outperformed SAC105 considerably, which in turn was much better than SAC305. The drop test performance was found to improve upon thermal aging at 150°C, and the difference between the alloys reduced significantly. This was explained by the speculated grain coarsening which resulted in a softened solder joint, and consequently, a shift of fracture mode from brittle failure toward ductile failure. This model was supported by the observation of the fractured surface moving away from the interface upon thermal aging. The improvement .
A Virtual Hope Box: Randomized Controlled Trial of a Smartphone App for Emotional Regulation and Coping With Distress.

OBJECTIVE The purpose of this study was to assess the impact of the Virtual Hope Box (VHB), a smartphone app to improve stress coping skills, suicidal ideation, and perceived reasons for living among patients at elevated risk of suicide and self-harm. METHODS The authors conducted a parallel-group randomized controlled trial with two groups of U.S. service veterans in active mental health treatment who had recently expressed suicidal ideation. Between March 2014 and April 2015, 118 patients were enrolled in the study. Participants were assigned to use the VHB (N=58) or to a control group that received printed materials about coping with suicidality (N=60) to supplement treatment as usual over a 12-week period. Three measures-the Coping Self-Efficacy Scale, Beck Scale for Suicidal Ideation, and Brief Reasons for Living Inventory-were collected at baseline (before randomization) and three, six, and 12 weeks. Secondary measures-the Interpersonal Needs Questionnaire, Perceived Stress Scale, and Columbia-Suicide Severity Rating Scale-were collected at baseline and 12 weeks. RESULTS VHB users reported significantly greater ability to cope with unpleasant emotions and thoughts (Coping Self-Efficacy Scale) at three (b=2.41, 95% confidence interval [CI]=.29-4.55) and 12 weeks (b=2.99, 95% CI=.08-5.90) compared with the control group. No significant advantage was found on other outcome measures for treatment augmented by the VHB. CONCLUSIONS The VHB is a demonstrably useful accessory to treatment-an easily accessible tool that can increase stress coping skills. Because the app is easily disseminated across a large population, it is likely to have broad, positive utility in behavioral health care.
On the roles of circulation and aerosols in the decline of mist and dense fog in Europe over the last 30 years

Abstract. Fog and mist are meteorological phenomena that have significant contributions to temperature variations. Understanding and predicting them is also crucial for transportation risk management. It has been shown that low visibility phenomena over Europe have been declining over the past three decades. The trends in mist and haze have been correlated to atmospheric aerosol trends. However, dense fog has not received yet such focus. The goal of this paper is to examine the roles of synoptic atmospheric circulation and aerosol content on the trends of dense fog. We show that sulphur emission trends are spatially correlated with visibility trends, with a maximum correlation when visibility is between 1 km and 10 km. We find that atmospheric dynamics overall contributes up to 40% of the variability of the frequency of fog occurrences. This contribution is spatially variable and highly depends on the topography and the season, with higher values in the winter. The observed long-term circulation changes do not contribute much to the trends in low visibility found in the data. This process is illustrated on three stations (De Bilt, Zurich Airport and Potsdam) for which a long-term visibility data and a thorough meteorological description are available. We conclude that to properly represent fog in future climate simulations, it is necessary to include realistic representations of aerosol emissions and chemistry, land surface properties and atmospheric dynamics.