Miracle-dz/UniFAR-FTUs huggingface dataset:
TRPV6 calcium channel translocates to the plasma membrane via Orai1-mediated mechanism and controls cancer cell survival

Significance Transient receptor potential vanilloid subfamily member 6 (TRPV6) is a highly selective Ca2+ channel that exercises its normal physiological function via Ca2+ absorption in the intestine and kidney. Intriguingly, we show that the TRPV6 channel may switch from its well-known constitutive activity to the store operated due to the remodeling mechanism involving STIM1/Orai1/TRPC1-induced activation of TRPV6 channel translocation to the plasma membrane via the Ca2+/Annexin I/S100A11 pathway. Moreover, we demonstrate that the discovered mechanism is used by prostate cancer cells. This channel is absent in healthy prostate and is expressed de novo in prostate cancer cells, where it changes the role by supplying Ca2+, which is used in cancer to increase cell survival. Transient receptor potential vanilloid subfamily member 6 (TRPV6) is a highly selective calcium channel that has been considered as a part of store-operated calcium entry (SOCE). Despite its first discovery in the early 2000s, the role of this channel in prostate cancer (PCa) remained, until now, obscure. Here we show that TRPV6 mediates calcium entry, which is highly increased in PCa due to the remodeling mechanism involving the translocation of the TRPV6 channel to the plasma membrane via the Orai1/TRPC1-mediated Ca2+/Annexin I/S100A11 pathway, partially contributing to SOCE. The TRPV6 calcium channel is expressed de novo by the PCa cell to increase its survival by enhancing proliferation and conferring apoptosis resistance. Xenografts in nude mice and bone metastasis models confirmed the remarkable aggressiveness of TRPV6-overexpressing tumors. Immunohistochemical analysis of these demonstrated the increased expression of clinical markers such as Ki-67, prostate specific antigen, synaptophysin, CD31, and CD56, which are strongly associated with a poor prognosis. Thus, the TRPV6 channel acquires its oncogenic potential in PCa due to the remodeling mechanism via the Orai1-mediated Ca2+/Annexin I/S100A11 pathway.
Social Cognition: Development, Neuroscience and Autism

List of Figures and Tables. Abbreviations. Preface. Part One Research and Social Cognition. 1. Social Cognition at the Crossroads: Perspectives on Understanding Others (Tricia Striano and Vincent Reid). 2. Research Methodology and Social Cognition (Vincent Reid and Elena Geangu). Part Two Cognitive Neuroscience. Editors' Introduction. 3. Do Adolescents Simulate? Developmental Studies of the Human Mirror Neuron System (Marco Iacoboni). 4. The Inhibition of Imitative Behavior and Attribution of Mental States (Marcel Brass and Stephanie Spengler). 5. Social Perception: Understanding Other People's Intentions and Emotions through their Actions (Julie Grezes and Beatrice de Gelder). 6. Development of the Social Brain during Adolescence (Sarah-Jayne Blakemore). 7. How do we Understand Others' Intentions? An Attentional Investigation (Pines Nuku and Harold Bekkering). Part Three Social Cognition during infancy. Editors' Introduction. 8. Memories for Events in Infants: Goal-Relevant Action Coding (Ildiko Kiraly). 9. The Interchange of Self-Performed Actions and Perceived Actions in Infants (Petra Hauf). 10. Tools and Goals: A Social-Cognition Perspective on Infant Learning of Object Function (Birgit Elsner). 11. The Directed-Attention Model of Infant Social Cognition: Further Evidence (Vincent Reid and Tricia Striano). 12. Reading Faces in Infancy: Developing a Multi-Level Analysis of a Social Stimulus (Tobias Grossmann and Amrisha Vaish). 13. The Perception of Emotional Expressions during Infancy (Stefanie Hoehl. Part Four Social Cognition: The challenge of autism. Editors' Introduction. 14. Face and Gaze Processing in Autism (Robert Joseph and Helen Tager-Flusberg). 15. Beyond Social Perception: The Case of Autism (Jessica Hobson and R. Peter Hobson). 16. The Role of Looking in Social Cognition: Perspectives from Development and Autism (Claes von Hofsten and Gustaf Gredeback). 17. What Does the Study of Autism Tell us about the Craft of Folk Psychology? (Richard Griffin and Daniel Dennett). 18. The Other End of the Spectrum? Social Cognition in Williams Syndrome (Jon Brock, Shiri Einav, and Deborah M. Riby). Part Five Commentaries. 19. Commentary: Mutual Recognition as a Foundation of Sociality and Social Comfort (Philippe Rochat). 20. Commentary on Social Cognition: Development, Neuroscience, and Autism (Charles Nelson). 21. Commentary: How Social is Social Cognition? (Simon Baron-Cohen). Index.
SPECTROCHEMICAL ANALYSIS OF SODIUM, POTASSIUM, CALCIUM, MAGNESIUM, COPPER, AND ZINC IN NORMAL HUMAN ERYTHROCYTES.

Although the mineral composition of the erythrocytes has been the subject of investigation for nearly half a century, the exact concentration of many of the elements in the cell has not been firmly established, and the information that is available is widely scattered throughout the literature. In most reports the composition of the cell is expressed per unit weight, per unit volume of packed cells, or per unit of cell water; there are only a few instances in which the average amount of element per cell has been reported (1-3). The average sodium concentration in centrifuged erythrocytes has been reported to be from as low as 168 MAg per g (4) to as high as 443 ug per g (5), and several textbooks (6-8) give a value of approximately 400 ug per g, which is not in accord with the results of recent investigation (913). In a few studies (9-13) correction for sodium in trapped plasma has been taken into consideration, but in others (14-21) it has been neglected. The removal of trapped plasma by washing erythrocytes has been recommended; however, the effect of this procedure on the chemical composition of the cell has not been extensively studied. In 1939 Streef (15) reported that the sodium concentration of erythrocytes declined when the cells were washed with isotonic salt or sugar solution, but recently Freeman and Spirtes (4) advocated washing erythrocytes with magnesium chloride for sodium analysis. Even though trapped plasma is not an important consideration in the determination of erythrocyte potassium, different laboratories have reported normal mean
Evaluating the Phobias, Attitudes, and Cultural Competence of Master of Social Work Students Toward the LGBT Populations

Abstract Background. Evidence suggests there is bias toward lesbian, gay, bisexual, and transgender (LGBT) persons by social workers; unfortunately, little research has been conducted to examine Master of Social Work (MSW) students' views toward these populations. The purpose of this study was to develop an assessment scale to evaluate the attitudes, phobias, and cultural competence of MSW students toward the LGBT populations. Methods. An assessment scale was developed and administered to MSW students (n = 173) at a Midwestern American university. Results. The majority of MSW students reported low phobia and a positive attitude toward the LGBT populations, yet participants reported having a low level of cultural competence in serving LGBT clients. Conclusion. More education and training is needed for MSW students to effectively serve the LGBT populations.
FPGA-Based Multimodal Embedded Sensor System Integrating Low- and Mid-Level Vision

Motion estimation is a low-level vision task that is especially relevant due to its wide range of applications in the real world. Many of the best motion estimation algorithms include some of the features that are found in mammalians, which would demand huge computational resources and therefore are not usually available in real-time. In this paper we present a novel bioinspired sensor based on the synergy between optical flow and orthogonal variant moments. The bioinspired sensor has been designed for Very Large Scale Integration (VLSI) using properties of the mammalian cortical motion pathway. This sensor combines low-level primitives (optical flow and image moments) in order to produce a mid-level vision abstraction layer. The results are described trough experiments showing the validity of the proposed system and an analysis of the computational resources and performance of the applied algorithms.
Modeling atmospheric sulfur over the Northern Hemisphere during the Aerosol Characterization Experiment 2 experimental period

A high-resolution (1{sup o} x 1{sup o}, 27 vertical levels) Eulerian chemical transport and transformation model for sulfate, SO{sub 2}, and related species driven by analyzed forecast meteorological data has been run for the Northern Hemisphere for June-July 1997 and extensively evaluated with observational data, mainly from air-quality and precipitation chemistry networks. For {approx}5000 evaluations, 50% of the modeled sulfate 24-h mixing ratios were within a factor of 1.85 of the observations; 50% of {approx}328 concurrent subgrid observations were within a factor of 1.33. Much greater subgrid variation for 24-h SO{sub 2} mixing ratios (50% of {approx}3552 observations were within a factor of 2.32) reflects high variability of this primary species; for {approx}12,600 evaluations 50% of modeled mixing ratios were within a factor of 2.54 of the observations. These results indicate that a substantial fraction of the modeled and observed differences is due to subgrid variation and/or measurement error. Sulfate mixing ratios are identified by source type (biogenic, volcanic, and anthropogenic) and production mechanism (primary and by gas-phase and aqueous-phase oxidation). Examination of key diagnostics showed substantial variation for the different types of sulfur, e.g., SO{sub 2} aqueous-phase oxidation rates of 29 to 102% day{sup -1}, sulfate residence times ofmore » 4 to 9 days. Volcanic emissions contributed 10% of the sulfate burden and 6% of emissions, because the elevated release allows 2 large fractional conversion of SO{sub 2} and long residence time. Biogenic SO{sub 2} was generally at lower concentrations than H{sub 2}O{sub 2}, resulting in efficient aqueous-phase oxidation; this source type contributed 13% of emissions but only 5% of sulfate burden. Anthropogenic sources were the dominant contributors to sulfur emissions, 80%, and sulfate burden, 84%. « less
The chlorine isotope fingerprint of the lunar magma ocean

The unusually heavy Cl of the Moon is related not to degassing of dry magmas but rather to the loss of Cl from the lunar magma ocean. The Moon contains chlorine that is isotopically unlike that of any other body yet studied in the Solar System, an observation that has been interpreted to support traditional models of the formation of a nominally hydrogen-free (“dry”) Moon. We have analyzed abundances and isotopic compositions of Cl and H in lunar mare basalts, and find little evidence that anhydrous lava outgassing was important in generating chlorine isotope anomalies, because 37Cl/35Cl ratios are not related to Cl abundance, H abundance, or D/H ratios in a manner consistent with the lava-outgassing hypothesis. Instead, 37Cl/35Cl correlates positively with Cl abundance in apatite, as well as with whole-rock Th abundances and La/Lu ratios, suggesting that the high 37Cl/35Cl in lunar basalts is inherited from urKREEP, the last dregs of the lunar magma ocean. These new data suggest that the high chlorine isotope ratios of lunar basalts result not from the degassing of their lavas but from degassing of the lunar magma ocean early in the Moon’s history. Chlorine isotope variability is therefore an indicator of planetary magma ocean degassing, an important stage in the formation of terrestrial planets.
En form av television. Globaliseringen av nationell TV-kultur

Det populaere svenske spil- og underholdningsprogram, Bingolotto, har vaeret vist pa national svensk tv lige sa laenge der har vaeret kommer- ciel tv i Sverige. Programmet har haft skiftende succe siden starten i 1991 og havde pa sit hojdepunkt over 2 milllioner seere. Artiklen be- skriver Bingolotto som et saerligt format inden for spil- og legeprogram- mer. Det sker gennem en diskussion af formatbegrebet i forhold til be- grebet genre, og gennem en identifikation af 4 karakteristiske dimen- sioner i formatbegrebet. Forfatteren fremhaever tv-formatet som en konceptuel beholder, der dels kan kapitaliseres, men som ogsa kun kan anvendes pa visse genrer. Desuden betragtes tv-formaternes fremvaekst som et slags kulturelt oversaettelsesarbejde i en globalise- ret tid, hvor internationale formater versioneres til et bestemt publikum ved at give formatet nationalt kulturelt saerpraeg.
An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase

The integrin family of cell surface receptors mediates cell adhesion to components of the extracellular matrix (ECM). Integrin engagement with the ECM initiates signaling cascades that regulate the organization of the actin-cytoskeleton and changes in gene expression. The Rho subfamily of Ras-related low-molecular-weight GTP-binding proteins and several protein tyrosine kinases have been implicated in mediating various aspects of integrin-dependent alterations in cell homeostasis. Focal adhesion kinase (FAK or pp125FAK) is one of the tyrosine kinases predicted to be a critical component of integrin signaling. To elucidate the mechanisms by which FAK participates in integrin-mediated signaling, we have used expression cloning to identify cDNAs that encode potential FAK-binding proteins. We report here the identification of a cDNA that encodes a new member of the GTPase-activating protein (GAP) family of GTPase regulators. This GAP, termed Graf (for GTPase regulator associated with FAK), binds to the C-terminal domain of FAK in an SH3 domain-dependent manner and preferentially stimulates the GTPase activity of the GTP-binding proteins RhoA and Cdc42. Subcellular localization studies using Graf-transfected chicken embryo cells indicates that Graf colocalizes with actin stress fibers, cortical actin structures, and focal adhesions. Graf mRNA is expressed in a variety of avian tissues and is particularly abundant in embryonic brain and liver. Graf represents the first example of a regulator of the Rho family of small GTP-binding proteins that exhibits binding to a protein tyrosine kinase. We suggest that Graf may function to mediate cross talk between the tyrosine kinases such as FAK and the Rho family GTPase that control steps in integrin-initiated signaling events.
Semantic browsing in large scale videos collection

With the increasing amount of video data being produced, there is a growing demand for more efficient tools of exploration and navigation to further improve the retrieval effectiveness. In this paper, we present a new approach for video browsing based on semantic and visual suggestions methodology. First, we describe a new method to build Semantic Concepts Network (SCN), which combines conceptual and contextual relationships among concepts. Second, we explore semantic links in SCN to propose new concepts and video shots that seems to be relevant for the user intent. A user study has shown that the proposed approach is able to help the user for semantic browsing in video collection.
Estimation of a physical model of the vocal folds via dynamic programming techniques

This work presents a procedure for the estimation of a two-mass vocal fold model starting from a time-varying target flow signal. The model is specified by a large number of physical parameters, computed as functions of four articulatory parameters (three laryngeal muscle activations and subglottal pressure). Flow waveforms synthesized by the model are characterized by means of a set of typical voice source quantification acoustic parameters. Given a sequences of target acoustic parameters, dynamic programming techniques and interpolation based on Radial Basis Function Networks are used to derive sequences of articulatory parameters that lead to resynthesis of the target signal.
History of Resuscitation.

One of the most overlooked areas of medicine has traditionally been the area of resuscitation. In the age of evidence-based medicine, where it is assumed most major questions have been studied, and guidelines and protocols are well established, it is useful to reflect on the history of resuscitation. Early attempts at resuscitation were efforts to stave off death and maladies caused by everyday dangers including trauma, drowning, and asphyxiation. As Dr Peter Safar wrote, “The history of resuscitation medicine is inseparable from the history of medicine in general. We and future generations of resuscitation researchers should learn from history to avoid reinventing the wheel, proving the obvious over and over again, and missing clues for potential break-throughs. ” For example, during the First World War, knowledge of ventilation, cardiac massage, defibrillation, electrocardiography, blood typing, and fluid resuscitation was discovered without any effective integration into the care of countless men and women who could have benefited from this knowledge. Resuscitation medicine has been plagued with many false starts; discoveries have been made and forgotten. However, the history of resuscitation is not completely filled with dead ends. For example, people noticed that a victim becomes pale and cold before death, and attempts to warm the body is one of the earliest known efforts at resuscitation. Methods to keep a person warm included starting a fire close by, placing a “volunteer” in bed with the patient so that the patient could gain body warmth, and even burying the patient in hot sand. The practice of restoring and maintaining body temperature has been, with few exceptions, a consistent part of resuscitation throughout history. However, for every positive example, there are practices that seem to have persisted, despite evidence of uselessness or harm. For centuries, if a person’s blood “looked bad,” bloodletting by the local barber or surgeon would ensue. It was documented that this would cause weakness or even death. By some estimates, President George Washington had an astounding 3.5L of blood
EVIDENCE BASED PSYCHOSOCIAL INTERVENTIONS FOR PEOPLE WITH SCHIZOFRENIA.

There is a growing interest in evidence based studies on the efficacy of psychotherapy that has led to the formation of task forces to define, identify, and disseminate information about empirically supported psychological interventions. Current data do not support the use of psychodynamic psychotherapy techniques for hospitalised people with schizophrenia. However the several structured studies that have been carried out showed that dynamic community meetings had the effect of reducing unfavorable ward incidents, in particular incidents with an aggressive character A modification of CBT "Assertive Community Treatment (ACT)"has been shown to facilitate that patients remain in contact with services. In terms of clinical and social outcome, significant and robust differences between ACT and standard community care were found on some socials variables but not on mental state or social functioning or quality of life. Psychoeducation significantly reduces relapse in schizophrenic patients and improve compliance to treatment. The so called Personal therapy improves social adjustment but can increase the rate of psychotic relapse for some patients living independently of their families. Family intervention may decrease hospitalisation and encourage compliance with medication but does not obviously effect the tendency of individuals/families to drop out of care. It may improve general social impairment and the levels of expressed emotion within the family. As for prevention measures it seems that even if the early detection and treatment of early signs appears to confer protection from relapse, the active ingredients of the pharmacological and psychological based treatment studies are as yet unclear On the other hand, many psychiatrists have reservations about the evidence-based medicine' approach because of perceived limitations in methodology gaps in interpreting the available evidence and neglect of individual patient uniqueness in quantitative research thru manualized treatment procedures.
GTPγS Regulation of a 12-Transmembrane Guanylyl Cyclase Is Retained after Mutation to an Adenylyl Cyclase*

DdGCA is a Dictyostelium guanylyl cyclase with a topology typical for mammalian adenylyl cyclases containing 12 transmembrane-spanning regions and two cyclase domain. InDictyostelium cells heterotrimeric G-proteins are essential for guanylyl cyclase activation by extracellular cAMP. In lysates, guanylyl cyclase activity is strongly stimulated by guanosine 5′-3-O-(thio) triphosphate (GTPγS), which is also a substrate of the enzyme. DdGCA was converted to an adenylyl cyclase by introducing three point mutations. Expression of the obtained DdGCAkqd in adenylyl cyclase-defective cells restored the phenotype of the mutant. GTPγS stimulated the adenylyl cyclase activity of DdGCAkqd with properties similar to those of the wild-type enzyme (decrease of K m and increase of V max), demonstrating that GTPγS stimulation is independent of substrate specificity. Furthermore, GTPγS activation of DdGCAkqd is retained in several null mutants of Gα and Gβ proteins, indicating that GTPγS activation is not mediated by a heterotrimeric G-protein but possibly by a monomeric G-protein.
Analyse longitudinale de la consolidation des comptes

Appearing in France in the sixties, the publication of consolidated accounts became compulsory with the law of January 3, 1985. This article shows who among the auditors, certified public accountants, the Conseil national de la comptabilite or prescribers, such as the Commission des operations de Bourse (COB), banks or financial analysts published the most in professional reviews about consolidated accounts. The aim is to identify the stakeholders who were implied in the promotion of this accounting practice. This contribution is based on 124 articles published on consolidated accounts in ten professional accounting reviews between 1954 and 1985. Methodology relies on the definition of a standard of homogenization (equivalent RFC) and the classification of the topics dealt with per period. It proves that banks and the COB, although they are prescribers, are interested slightly in this set of themes and that certified public accountants, however directly concerned with consolidated accounts have only invested this field in the early seventies
Recorded Lectures: An Opportunity for Improved Teaching and Learning

The use of recorded lectures is increasing in universities at a time when technology makes those recorded lectures readily available. The increased use of recordings has coincided to some degree with declining attendances by students at on campus lectures. The recording of lectures may be one factor contributing to declining student attendance but it is unlikely to be the most significant factor. There may be many other factors influencing student attendance. The recording of lectures should be embraced because it has the potential to enhance student learning and it provides access to tertiary education for many students who may, for various reasons, be unable to attend campus on a regular basis.