Miracle-dz/UniFAR-FTUs huggingface dataset:
Mechanism of Generation of Therapy Related Leukemia in Response to Anti-Topoisomerase II Agents

Type II DNA topoisomerases have the ability to generate a transient DNA double-strand break through which a second duplex can be passed; an activity essential for DNA decatenation and unknotting. Topoisomerase poisons stabilize the normally transient topoisomerase-induced DSBs and are potent and widely used anticancer drugs. However, their use is associated with therapy-related secondary leukemia, often bearing 11q23 translocations involving the MLL gene. We will explain recent discoveries in the fields of topoisomerase biology and transcription that have consequences for our understanding of the etiology of leukemia, especially therapy-related secondary leukemia and describe how these findings may help minimize the occurrence of these neoplasias.
Control scheme for efficiency improvement of slim type BLDC Motor

Brushless DC (BLDC) Motor is widely used in home appliance, robot, and vehicle industry due to the merits of high power density, low noise, and simple controllability. A demands for the motor, especially slim-type BLDC motor, is expected to increase continuously since the minimizing trend of the actuators is getting attention from various applications. Because a phase inductance of the slim-type BLDC motor is large, it causes a lagging of current compared with back-electromotive force (EMF) in wide range of speed. As a result, there is a problem that reduces the motor efficiency and increases the phase current. Particularly the problem is more serious in high speed range and heavy load condition. This paper proposed control scheme for high efficiency of slim type BLDC motor which can resolve the problems as mentioned above. To synchronize the phase between the current and back-EMF of BLDC motor, it proposed lead angle control method by using current dynamics characteristic. Also, it represented the accurate calculating method of lead angle by using only the maximum value of phase current and information of DC-link voltage. For the verification of the proposed control scheme, various simulations and experiments are employed. As a result, the efficiency improvement of slim type BLDC motor is confirmed.
Psychiatric Diagnoses in Individuals with Non-Syndromic Oral Clefts: A Danish Population-Based Cohort Study

Background The aim of this study was to investigate the risk of psychiatric diagnoses in individuals with non-syndromic oral clefts (OC) compared with individuals without OC, including ages from 1 to 76 years. Methods Linking four Danish nationwide registers, we investigated the risk of psychiatric diagnoses at Danish psychiatric hospitals during the period 1969–2012 for individuals born with non-syndromic OC in Denmark 1936–2009 compared with a cohort of 10 individuals without OC per individual with OC, matched by sex and birth year. The sample included 8,568 individuals with OC, observed for 247,821 person-years, and 85,653 individuals without OC followed for 2,501,129 person-years. Results A total of 953 (11.1%) of the individuals with OC (9.6% for cleft lip (CL), 10.8% for cleft lip and palate (CLP) and 13.1% for cleft palate (CP)) and 8,117 (9.5%) in the comparison group had at least one psychiatric diagnosis. Cox proportional hazard regression model revealed that individuals with OC had significantly higher risk of a psychiatric diagnosis (hazard ratio (HR) = 1.19, 95% CI: 1.12–1.28). When examining cleft type, no difference was found for CL (HR = 1.03, 95% CI: 0.90–1.17), but CLP was associated with a small increased risk (HR = 1.13, 95% CI: 1.01–1.26), whereas individuals with CP had the largest increased risk (HR = 1.45, 95% CI: 1.30–1.62). The largest differences were found in schizophrenia-like disorders, mental retardation and pervasive developmental disorders, but we found no increased risk of mood disorders and anxiety-related disorders. Conclusion Individuals with non-syndromic OC had significantly higher risk of psychiatric diagnoses compared with individuals without OC. However, the elevated risk was observed for individuals with CLP and CP but not for individuals with CL and the absolute risk increase was modest.
The Effect of Production of Selected Agriculture Products and Money Supply on GDP of Agriculture Sector in Malaysia

Agriculture sector plays the vital role in Malaysian economic because of the contribution of agriculture during the early stages of the national economic growth until now. The purpose of this paper is to examine the effects of the selected agriculture sector (palm oil, rubber, rice and saw logs) in the agriculture sector and to examine the impact of money supply across employment and productivity of labour and capital in agriculture sector. This paper uses the secondary data from year 1981 until 2010 from the Department of Statistics Malaysia, Malaysia Productivity Corporation (MPC) and Asian Development Bank (ADB). By using Johansen-Julies Cointegration model, the results showed there is long run relationship between dependent variable and independent variables. But, in Granger Causality model, result showed there is no relationship between money supply and productivity variables. While, this paper also conducts other tests such as Autocorrelation, Ramsey RESET and Histogram Normality Test.
Efficacy of fluticasone on cough: a randomised controlled trial

Cough may be the consequence of bronchial hyperresponsiveness (BHR) and inflammation. This study was designed to investigate the short-term effects of an inhaled steroid (fluticasone propionate (FP)) on cough, and to determine the effects of smoking, BHR, allergy and forced expiratory volume in one second (FEV1) on the efficacy of FP. In a community-based primary healthcare centre, 135 previously healthy adults suffering from cough for ≥2 weeks were enrolled in a randomised, double-blind, placebo-controlled trial of inhaled FP 500 µg b.i. d. for 2 weeks. Participants completed daily diary cards of lower respiratory tract symptoms. The primary outcome measure was the decrease in mean total daily cough score (0–6) during the second week of treatment. In the FP group, the cough score decreased from 3.8 at baseline to mean±sem 1.4±0.2 during the second week. In the placebo group, this decrease was from 3.8 to 1.9±0.1 and was statistically significantly less. A favourable effect of FP was only detectable in nonsmokers, in whom the score was 0.9 points lower compared with placebo. The clinical relevance of this finding has to be established further. Allergy, FEV1 and BHR at baseline did not affect the efficacy of FP. In conclusion, anti-inflammatory treatment with the inhaled steroid fluticasone propionate reduces cough in otherwise healthy adults who do not smoke.
The male-female wage gap in France - differences across the wage distribution

We use a semi-parametric method to decompose the difference in male and female wage densities into two parts--one explained by characteristics and one which is attributable to differences in returns to characteristics. We demonstrate that one learns substantially more about the gender wage gap in France through this analysis than through standard parametric techniques. In particular, we find that there are no unexplained differences in male and female earnings distributions in the bottom fifth of the data. Occupation and part-time status are the most important determinants of the wage gap for all workers. In the semi-parametric estimates we find that education plays no role in the wage gap once we account for occupation and part-time status. JEL Codes: J16 J31 J7
Expanding touch input vocabulary by using consecutive distant taps

In recent years, touch screens have emerged and matured as the main input interface for mobile and tablet computers calling for extended touch input possibilities. In this paper, we explore the use of consecutive distant taps to expand the touch screen input vocabulary. We analyzed time intervals and distances between consecutive taps during common applications on a tablet and verified that consecutive distant taps can be used conflict-free with existing touch gestures. We designed the two interaction techniques Ta-tap and Ta-Ta-tap that utilize consecutive distant taps. Ta-tap uses two consecutive distant taps to invoke alternative touch operations for multi-touch emulation, whereas Ta-Ta-tap uses a series of consecutive distant taps to define a spatial gesture. We verified the feasibility of both interaction techniques through a series of experiments and a user study. The high recognition rate of Ta-tap and Ta-Ta-tap gestures, the few conflicts with existing gestures, and the positive feedback from the participants assert the potential of consecutive distant taps as a new design space to enrich touch screen interactions.
Improving text classification using local latent semantic indexing

Latent semantic indexing (LSI) has been shown to be extremely useful in information retrieval, but it is not an optimal representation for text classification. It always drops the text classification performance when being applied to the whole training set (global LSI) because this completely unsupervised method ignores class discrimination while only concentrating on representation. Some local LSI methods have been proposed to improve the classification by utilizing class discrimination information. However, their performance improvements over original term vectors are still very limited. In this paper, we propose a new local LSI method called "local relevancy weighted LSI" to improve text classification by performing a separate single value decomposition (SVD) on the transformed local region of each class. Experimental results show that our method is much better than global LSI and traditional local LSI methods on classification within a much smaller LSI dimension.
A Defense of Shareholder Favoritism

This paper considers the efficiency implications of managerial "favoritism" towards block shareholders of public corporations. While favoritism can take any number of forms (including the payment of greenmail, diversion of opportunities, selective information disclosure, and the like), each may have the effect (if not the intent) of securing a block shareholder's loyalty in order to entrench management. Accordingly, the practice of making side payments is commonly perceived to be contrary to other shareholders' interests and, more generally, inefficient. In contrast to this received wisdom, we argue that when viewed ex ante, permissible acts of patronage toward block shareholders may play an important efficiency role that benefits all shareholders alike. We demonstrate that the prospect of having to share rents with a third party may itself have a deterrent effect on managerial self-dealing - an off-equilibrium benefit that would not be readily apparent if one looked only at instances where favoritism actually occurs in practice.
Global and local QoS constraints guarantee in Web service selection

In service oriented architectures, complex applications are composed from a variety of functionally equivalent Web services, which may differ for quality parameters. Under this scenario, applications are defined as high level business processes and service composition can be implemented dynamically by identifying the best set of services available at run time. In this paper, we model the service composition problem as a mixed integer linear problem where both local constraints and global constraints can be specified.
Image classification based on multi-feature combination and PCA-RBaggSVM

In conventional image classification methods, complementary advantages between various single features of images are not fully applied; meanwhile, redundant information exists in the extracted features. As a result, accuracy of image classification is not high. Therefore, a novel approach for image classification based on multi-feature combination and PCA-RBaggSVM (principal component analysis and random bagging support vector machine) is proposed in the paper. First, comprehensive features describing fully image content are extracted, then redundant information is removed by transforming extracted features with PCA. Finally, RBaggSVM of ensemble SVM classifier is applied for classification. Experimental result shows that the method has higher accuracy and faster speed of image classification than similar methods.
A Chinese hamster ovary cell mutant defective in the non-endocytic uptake of fluorescent analogs of phosphatidylserine: isolation using a cytosol acidification protocol

Transmembrane movement of phosphatidylserine (PS) and various PS analogs at the plasma membrane is thought to occur by an ATP-dependent, protein-mediated process. To isolate mutant CHO cells defective in this activity, we first obtained conditions which inhibited the endocytic, but not the non-endocytic pathway of lipid internalization since PS may enter cells by a combination of these two pathways. We found that acidic treatment of cells, which blocks clathrin-dependent endocytosis, enhanced the energy-dependent uptake of 1-palmitoyl-2-(6-[(7-nitrobenz- 2-oxa-1,3-diazol-4-yl)amino]caproyl -sn- glycero-3-phosphoserine (C6- NBD-PS) in CHO cells from donor vesicles (liposomes) by about twofold. Control experiments demonstrated that the enhanced uptake of C6-NBD-PS at acidic pH was not due to: (a) an increase in the capacity of the plasma membrane to incorporate C6-NBD-PS from the donor vesicles; (b) a decrease in the rate of loss of C6-NBD-PS from the cells; or (c) fusion or engulfment of the donor vesicles. When cytosolic acidification (to pH 6.3) was imposed without acidification of the extracellular medium, C6-NBD-PS uptake by intact cells was increased by about 50% compared to control values determined in the absence of acidification. These results suggested that a protein and energy dependent system(s) for transbilayer movement of the fluorescent PS was stimulated by cytosolic acidification. A screening method for mutant cells defective in the non- endocytic uptake of fluorescent PS analogs with replica cell colonies at acidic pH was then devised. After selection of mutagenized CHO-K1 cells by in situ screening, we obtained a mutant cell line in which uptake of fluorescent PS analogs was reduced to about 25% of the wild type level at either pH 6.0 or 7.4. Control experiments demonstrated that the reduced uptake of fluorescent PS analogs in the mutant cells was unrelated to multidrug resistance, and that endocytosis of another plasma membrane lipid marker occurred normally in the mutant cells. These results suggested that a non-endocytic pathway responsible for uptake of fluorescent PS analogs was specifically affected in the mutant cells.
Microsatellite Scan Identifies New Candidate Genes for Susceptibility to Alcoholic Chronic Pancreatitis in Japanese Patients

Alcohol abuse is one of the most common risk factor for chronic pancreatitis, but the underlying pathophysiological mechanisms remain unclear. The aim of this study was to identify genes that contribute to susceptibility or resistance for alcoholic chronic pancreatitis by screening the whole genome. Sixty-five patients with alcoholic chronic pancreatitis (63 men and 2 women, mean age 55.2 years) and 99 healthy Japanese controls were enrolled in this study. This was an association study using 400 polymorphic microsatellite markers with an average spacing of 10.8 cM distributed throughout the whole genome. This search revealed 10 candidate susceptibility regions and 5 candidate resistant regions throughout the genome. No specific microsatellite markers were detected in association with previously reported susceptibility genes for chronic pancreatitis, such as PRSS1, PRSS2, CTRC, SPINK1, CFTR, ALDH2, and CYP2E1. Among the statistically significant markers, D15S1007 on chromosome 15q14 showed strong evidence for disease susceptibility (70.8% vs. 35.1%, Pc = 0.0001). Within 500 kb of D15S1007, several genes were candidate genes for susceptibility, including FMN1, DKFZP686C2281, LOC440268, RYR3, and AVEN, This study identified 10 candidate susceptibility and 5 candidate resistant regions that may contain genes involved in ACP pathogenesis.
Information Systems ( ICIS ) 1-1-2009 Identifying Cohesive Local Community Structures in Networks

Identifying community structure in networks is an important topic in data mining research. One of the challenges is to find local communities without requiring the global knowledge of the entire network. Exiting techniques have several limitations. First, there is no widely accepted definition for community. Second, these algorithms either lack good stopping criteria or depend on predefined threshold parameters. In this research I propose a local cohesion based algorithm to identify local communities in networks. This algorithm is grounded on the widely accepted group cohesion definition in social network analysis research. The algorithm is self-contained and does not depend on predefined threshold parameter to terminate the identification process. The evaluation results show that the proposed algorithm is more effective than the benchmark algorithm and can identify meaningful local communities in very large networks such as the Amazon co-purchasing network.
Some Learning Algorithms for Phonotactics

Aromatic hydrocarbon impurities are removed from a liquid paraffin containing the same by contacting the liquid paraffin in the liquid phase at relatively low temperatures with an X-type zeolite molecular sieve material. The contacting is performed without recycle and purified liquid paraffin containing less than about 0.01% by weight aromatics is obtained.
Numerical analysis of pulsed I-V curves and current collapse in GaN FETs as affected by buffer trapping

Two-dimensional transient analysis of GaN MESFETs is performed in which a three-level compensation model is adopted for a semi-insulating buffer layer, where a shallow donor, a deep donor and a deep acceptor are considered. Quasi-pulsed I-V curves are derived from the transient characteristics, and are compared with the steady-state I-V curves. It is shown that so-called current collapse or current reduction is more pronounced when the deep-acceptor density in the buffer layer is higher and when an off-state drain voltage is higher, because the trapping effects become more significant. It is suggested that to minimize current collapse in GaN-based FETs, an acceptor density in a semi-insulating GaN layer should be made low, although the current cutoff behaviour may be degraded.
MtiBase: a database for decoding microRNA target sites located within CDS and 5′UTR regions from CLIP-Seq and expression profile datasets

MicroRNAs (miRNAs) play an important role in the regulation of gene expression. Previous studies on miRNA functions mainly focused on their target sites in the 3′ untranslated regions (UTRs) of mRNAs. However, increasing evidence has revealed that miRNAs can also induce mRNA degradation and mediate translational repression via complementary interactions with the coding sequence (CDS) and 5′UTR of mRNAs. In this study, we developed a novel database, MtiBase, to facilitate the comprehensive exploration of CDS- and 5′UTR-located miRNA target sites identified from cross-linking immunoprecipitation sequencing (CLIP-Seq) datasets and to uncover their regulatory effects on mRNA stability and translation from expression profile datasets. By integrating 61 Argonaute protein-binding CLIP-Seq datasets and miRNA target sites predicted by five commonly used programs, we identified approximately 4 400 000 CDS-located and 470 000 5′UTR-located miRNA target sites. Moreover, we evaluated the regulatory effects of miRNAs on mRNA stability and translation using the data from 222 gene expression profiles, and 28 ribosome-protected fragment sequencing, and six pulsed stable isotope labeling with amino acids in culture. Finally, the effects of SNPs on the functions of miRNA target sites were systematically evaluated. Our study provides a useful tool for functional studies of miRNAs in regulating physiology and pathology. Database URL: http://mtibase.sysu. edu.cn
A Strategy for Addressing the Needs of Advanced Scientific Computing Using Eclipse as a Parallel Tools Platform

If parallel computer systems are to achieve the kinds of productivity improvements necessary to meet the needs of high productivity computing systems (HPCS), then a radical change will be required in how tools are developed for programmers and users of these systems. The number and complexity of tools is making it difficult for developers to access and use the tools effectively, and the lack of a common tool infrastructure significantly complicates tool development efforts. The rapid pace of change means that developing and maintaining the kinds of tools that will be needed to effectively utilize the capacity of future advanced computer systems is an increasingly onerous task. This paper proposes a strategy that will lead directly to productivity and quality improvements in the development and use of parallel applications, and that will provide a framework to guide and foster future tool development. This strategy is based on using the Eclipse platform to form the foundation of an integrated environment for parallel application development. The intention is not just to produce another set of tools, however, but rather to use Eclipse as both a focal point for tool development, and as a platform for producing highly integrated tools that are needed to meet the future needs of the HPC community.
Plasma 25-hydroxyvitamin D levels and fracture risk in a community-based cohort of elderly men in Sweden.

CONTEXT Blood levels of 25-hydroxyvitamin D [25(OH)D] is the generally accepted indicator of vitamin D status, but no universal reference level has been reached. OBJECTIVE The objective of the study was to determine the threshold at which low plasma 25(OH)D levels are associated with fractures in elderly men and clarify the importance of low levels on total fracture burden. DESIGN AND PARTICIPANTS In the Uppsala Longitudinal Study of Adult Men, a population-based cohort (mean age, 71 yr, n = 1194), we examined the relationship between 25(OH)D and risk for fracture. Plasma 25(OH)D levels were measured with high-pressure liquid chromatography-mass spectrometry. SETTING The study was conducted in the municipality of Uppsala in Sweden, a country with a high fracture incidence. MAIN OUTCOME MEASURE Time to fracture was measured. RESULTS During follow-up (median 11 yr), 309 of the participants (26%) sustained a fracture. 25(OH)D levels below 40 nmol/liter, which corresponded to the fifth percentile of 25(OH)D, were associated with a modestly increased risk for fracture, multivariable-adjusted hazard ratio 1.65 (95% confidence interval 1.09-2.49). No risk difference was detected above this level. Approximately 3% of the fractures were attributable to low 25(OH)D levels in this population. CONCLUSIONS Vitamin D insufficiency is not a major cause of fractures in community-dwelling elderly men in Sweden. Despite the fact that cutaneous synthesis of previtamin D during the winter season is undetectable at this northern latitude of 60 degrees, only one in 20 had 25(OH)D levels below 40 nmol/liter, the threshold at which the risk for fracture started to increase. Genetic adaptations to limited UV light may be an explanation for our findings.