Miracle-dz/UniFAR-FTUs huggingface dataset:
Untargeted, High-Resolution Metabolomics in Pediatric Eosinophilic Esophagitis

Background/Objectives: Eosinophilic esophagitis (EoE) is an inflammatory disease of unclear etiology. The aim of this study was to use untargeted plasma metabolomics to identify metabolic pathway alterations associated with EoE to better understand the pathophysiology. Methods: This prospective, case-control study included 72 children, aged 1–17 years, undergoing clinically indicated upper endoscopy (14 diagnosed with EoE and 58 controls). Fasting plasma samples were analyzed for metabolomics by high-resolution dual-chromatography mass spectrometry. Analysis was performed on sex-matched groups at a 2:1 ratio. Significant differences among the plasma metabolite features between children with and without EoE were determined using multivariate regression analysis and were annotated with a network-based algorithm. Subsequent pathway enrichment analysis was performed. Results: Patients with EoE had a higher proportion of atopic disease (85.7% vs 50%, P = 0.019) and any allergies (100% vs 57.1%, P = 0.0005). Analysis of the dual chromatography features resulted in a total of 918 metabolites that differentiated EoE and controls. Glycerophospholipid metabolism was significantly enriched with the greatest number of differentiating metabolites and overall pathway enrichment (P < 0.01). Multiple amino and fatty acid pathways including linoleic acid were also enriched, as well as pyridoxine metabolism (P < 0.01). Conclusions: In this pilot study, we found differences in metabolites involved in glycerophospholipid and inflammation pathways in pediatric patients with EoE using untargeted metabolomics, as well as overlap with amino acid metabolome alterations found in atopic disease.
Experimental study of endurance characteristics of Al-doped HfO2 ferroelectric capacitor

In this work, the endurance characteristics of Al-doped HfO2 (HAO)-based metal-ferroelectric-metal (MFM) capacitors (which were annealed at 1000 °C) with various doping concentrations were investigated. The doping concentration was optimized for the high annealing temperature (1000 °C) process. To investigate the impact of cycling pulses on the endurance characteristics of HAO-based MFM capacitor, the rise/fall time (t r/f ) and hold time (th ) for the cycling pulses were varied. Moreover, by adopting the recoverable fatigue process, the endurance characteristics under repetitive wake-up/fatigue processes were studied. The HAO capacitors achieved the remnant polarization (2Pr) of 23.767 μC cm−2 at pristine state under the high annealing temperature. Furthermore, it was demonstrated that the endurance characteristics (∼108 cycles) of the HAO capacitors were comparable to them of other HfO2-based ferroelectric capacitors. Lastly but not least, it turned out that the amount of oxygen and oxygen vacancies in the HAO thin film was dependent of doping concentrations for the film. The impact of oxygen and oxygen vacancies was quantitatively analyzed, in detail, with TEM, XPS and GIXRD analysis.
Theory and measurement of plasmonic terahertz detector response to large signals

Electron gas in the conduction channel of a Field Effect Transistor (FET) can support collective plasma oscillations tunable by the gate voltage. In the Dyakonov-Shur terahertz (THz) detector, nonlinearities in the plasma wave propagation in the gated channel of a FET lead to a constant source-to-drain voltage providing the detector output. We present the detector theory in the frame of the hydrodynamic model using the electron plasma Navier-Stokes and thermal transport equations, thus fully accounting for the hydrodynamic non-linearity, the viscosity, and pressure gradients in the detector response. Both resonant and broadband operations of the high electron mobility transistor (HEMT) based plasmonic detectors are described by this model. The relation between the electron channel density and gate voltage was modeled by the unified charge control model applicable both above and below the threshold voltage. The theoretical results are compared with the response measured in the short channel InGaAs HEMT and.
Estimation of unimodal densities without smoothness assumptions

The Grenander estimator of a decreasing density, which is defined as the derivative of the concave envelope of the empirical c.d. f. , is known to be a very good estimator of an unknown decreasing density on the half-line R + when this density is not assumed to be smooth. It is indeed the maximum likelihood estimator and one can get precise upper bounds for its risk when the loss is measured by the L 1 -distance between densities. Moreover, if one restricts oneself to the compact subsets of decreasing densities bounded by H with support on [0, L] the risk of this estimator is within a fixed factor of the minimax risk. The same is true if one deals with the maximum likelihood estimator for unimodal densities with known mode. When the mode is unknown, the maximum likelihood estimator does not exist any more. We shall provide a general purpose estimator (together with a computational algorithm) for estimating nonsmooth unimodal densities. Its risk is the same as the risk of the Grenander estimator based on the knowledge of the true mode plus some lower order term. It can also cope with small departures from unimodality.
The effects of bending strain on the critical current and AC loss of BSCCO/Ag tapes

When a coil or a winding is made, the superconducting tapes must be bent to different curvatures. Bending of high temperature superconducting (HTS) tapes can result in degradation of the critical current density and thus increase the AC losses of the tapes. Therefore, the effects of bending strain on the critical current and AC loss should be considered in the design of high temperature superconducting apparatus. In this paper, the dependence of critical current and AC loss on the bending diameter of the superconductor tape was experimentally investigated. The diameters of the curved tape were varied from 110 to 36 mm. AC loss measurements were taken at 77 K, 50 Hz. Analysis of the bending strain effects on the critical current and AC loss are presented. An expression describing the dependence of AC losses on bending strain is proposed by modifying Norris' formula. The experimental results are presented and compared with the calculated values.
Common High-Speed Running Thresholds Likely Do Not Correspond to High-Speed Running in Field Sports

Abstract Freeman, BW, Talpey, SW, James, LP, Opar, DA, and Young, WB. Common high-speed running thresholds likely do not correspond to high-speed running in field sports. J Strength Cond Res 37(7): 1411–1418, 2023—The purpose of this study was to clarify what percentage of maximum speed is associated with various running gaits. Fifteen amateur field sport athletes (age = 23 ± 3.6 years) participated in a series of 55-meter running trials. The speed of each trial was determined by instructions relating to 5 previously identified gait patterns (jog, run, stride, near maximum sprint, and sprint). Each trial was filmed in slow motion (240 fps), whereas running speed was obtained using Global Positioning Systems. Contact time, stride angle, and midstance free-leg knee angle were determined from video footage. Running gaits corresponded with the following running speeds, jogging = 4.51 m·s−1, 56%Vmax, running = 5.41 m·s−1, 66%Vmax, striding = 6.37 m·s−1, 78%Vmax, near maximum sprinting = 7.08 m·s−1, 87%Vmax, and sprinting = 8.15 m·s−1, 100%Vmax. Significant (p < 0.05) increases in stride angle were observed as running speed increased. Significant (p < 0.05) decreases were observed in contact time and midstance free-leg knee angle as running speed increased. These findings suggest currently used thresholds for high-speed running (HSR) and sprinting most likely correspond with jogging and striding, which likely underestimates the true HSR demands. Therefore, a higher relative speed could be used to describe HSR and sprinting more accurately in field sports.
The Biomarker Ki-67: Promise, Potential, and Problems in Breast Cancer

Ki-67 is a nuclear protein serendipitously discovered by monoclonal antibody selection in the early 1980s. While it has been applied for decades in the context of breast cancer as a putative prognostic and, more recently, predictive, biomarker, even after all this time there is incomplete agreement as to the validity of the immunohistochemical assays employed for Ki-67 assessment, given possible effects of the disparate methodologies employed and possible confounding preanalytical, analytical, and interpretive variables. In this brief review, the history of Ki-67 and the problems, particularly with the analytical and interpretive variables, are highlighted through a selective review of the published literature. The contributions of the International Ki-67 Breast Cancer Working Group are highlighted, and in particular, the recommendations made by this group are reviewed. The potential of Ki-67 as a biomarker for breast cancer has not yet been fully realized, but an understanding of the power as well as the limitations of the methods of Ki-67 assessment are important if this biomarker can realize its potential.
Stroke Counseling Intervention for Young Adult African Americans

Background African Americans have a higher incidence of early-onset stroke and poorer stroke-related outcomes than other race/ethnic groups. Objectives Our two-arm, randomized controlled trial was implemented to assess efficacy of the nurse-led Stroke Counseling for Risk Reduction (SCORRE) intervention in reducing stroke risk in young African American adults by improving accuracy of perceived stroke risk and lifestyle behaviors (i.e., diet, physical activity, and smoking cessation). Stroke knowledge, behavior change readiness, and perceived competence to live a healthy lifestyle were also explored as secondary outcomes. Methods African Americans aged 20–35 years, recruited from an urban university and surrounding community, were randomized to SCORRE or an attention placebo control group receiving safe sex education. Data were collected pre-intervention, immediate post-intervention, and at 8 weeks. Multilevel models were used for primary outcome analyses. Results Participants (n = 106) were mostly in their mid-20s, female, college students, and averaged about three modifiable stroke risk factors. Compared to the control group, participants in the intervention group had, on average, a significant increase in accuracy of perceived stroke risk post-intervention, a greater change in perceived competence to live healthy, and a greater increase in dietary components at 8 weeks. Significant changes were not found in physical activity and other outcomes. Discussion These findings suggest that SCORRE is a promising intervention to reduce stroke risk among young African American adults. Results will inform a more robust, randomized controlled trial of SCORRE to have an age, culture, and gender-focused intervention that effectively reduces stroke risk among African Americans early in life.
Analysis of siblings’ relationship and parenting style using structure modelling approach

Relationships among siblings play a crucial role in early socialization and further social development. Siblings inherently belong to the system of family relationships; their observation without involving parent-child bonds, is to some extent, generalization. Therefore, our research analyzes with mutual connections between parenting styles and the characteristics of siblings’ relationships in a family using a quantitative design of data collection and processing. The outputs from the Sibling Relationship Questionnaire and Questionnaire of Parenting Styles in a Family were collected from 264 bachelor’s students. The study found the overall associations of positive emotional relationships and freedom provided by parents with generally desirable characteristics of siblings’ bonds and vice versa, and associations between negative emotional relationships and requirements with negatively perceived traits of siblings’ bonds. The unexpected outcome of our research is that it revealed more connections between paternal parenting styles and the characteristics of sibling relationships than with those of maternal parenting styles. To reflect the complexity of these relationships more precisely, complex structural equation models were created and successfully adjusted.
Factors affecting collaboration between clinical and community service organizations

Background Collaboration between clinical and community-based social service organizations is increasingly seen as vital for preventing and managing chronic diseases but has been challenging to establish and sustain. Purpose The aim of this study was to identify organizational barriers and facilitators for clinic–community collaboration. Methodology/Approach We employed multiple methods to study a national sample of nonprofit community-based organizations that each collaborated with local clinical organizations for diabetes prevention in the United States. We used qualitative data collected longitudinally through 65 semistructured interviews from 2016 to 2017 at seven of these organizations and their clinical collaborators to understand their relationships. We employed survey data (N = 247 with 73% response rate) to measure and explore relationships among qualitatively identified themes and collaboration performance. Results We documented three levels of organizational challenges to community–clinic collaboration. Interorganizational challenges pertain to facing only weakly aligned interests across organizations. Interpersonal challenges pertain to misperceptions and miscommunications that occur as frontline employees from differing organizations seek to work together. Task-related challenges pertain to the inadequacy of current processes to effectively link services across clinical and community settings. We found that bridging leadership, provisional teamwork, and learning processes helped to overcome these challenges by enabling iterative progress. Follow-up national survey results indicated that these facilitators were significantly associated with collaboration performance. Conclusions Because community–clinic collaboration presents substantial interorganizational, interpersonal, and task-related challenges, financial incentives alone are likely insufficient for success. Practice Implications Resources that help develop capacity to work across community and clinical settings may be vital and warrant dedicated funding.
Micronized Cellular Adipose Matrix Promotes the Therapeutic Effect of an Artificial Nerve Conduit in Peripheral Nerve Gap Injury

Background: Stromal vascular fraction (SVF) isolated from adipose tissue has been shown to be beneficial for treating peripheral nerve injuries. Micronized cellular adipose matrix (MCAM) is an SVF-rich micronized fat tissue obtained by a series of simple mechanical processes. This study assessed the therapeutic effect of MCAM for peripheral nerve injury. Methods: Microscopic evaluation of the cell phenotype and functions was performed to determine the adipose-derived stem cell content of the MCAM. An artificial nerve conduit (ANC) filled with MCAM was implanted into a sciatic nerve defect in immunodeficient mice. Comparisons of this treatment with an autograft, an ANC filled with SVF cells, and an ANC alone were made based on electrophysiologic characteristics, Sciatic Functional Index, and histologic analyses of regenerated nerve fiber and myelination using electron microscopy, and the preventive effect on innervated muscle atrophy. Results: MCAM contained many cells with a phenotype and differentiation potency similar to those of ADSCs. The implantation experiment indicated that MCAM enhanced the efficiency of functional and structural recovery and prevented atrophy of the innervated muscle. These effects were significantly improved compared with the control group (ANC only) and comparable to those in the SVF group, whereas the improvement did not reach the same level of the autograft group. Conclusion: Injection of MCAM into an ANC accelerated nerve regeneration compared with use of an ANC alone, which indicates that MCAM is a promising transplant material for treatment of peripheral nerve injury and an alternative to use of SVF cells. Clinical Relevance Statement: Micronized cellular adipose matrix, which can be harvested and isolated from adipose tissue with a simple device, has been shown for the first time to be highly useful as an implantable material for new peripheral nerve regeneration.
The Preexposure Prophylaxis Care Continuum Among Mexican Men Who Have Sex With Men and Transwomen: A Qualitative Study

This study found that the main barriers for engaging in preexposure prophylaxis were the fear of adverse effects, unmet information needs of transwomen, and the effort required to attend visits. Background This article describes perceptions and experiences related to the preexposure prophylaxis (PrEP) care continuum of Mexican men who have sex with men (MSM) and transwomen (TW). Methods Between June and July 2020, we applied 24 online semistructured interviews regarding PrEP use with 10 PrEP users, 6 ex-users, and 8 potential users (at risk, not enrolled). Results Awareness: TW did not always receive the information they needed from trusted people. Acceptability: Potential users were reluctant to use PrEP because of fear of adverse effects, and only a few participants worried about stigma. Uptake: Potential users missed their enrollment visit and did not know how to reschedule. Adherence: Barriers included routine changes interfering with PrEP-taking habits (arriving home later, traveling, etc.), whereas feeling protected was reported as a facilitator. Retention: Ex-users quit PrEP services, mostly without reducing their HIV risk, because of difficulties keeping appointments and fearing long-term effects. Conclusion Inclusive awareness activities, tackling misbeliefs regarding adverse effects, and more flexible services may improve PrEP usage and enhance its impact.
Odorant-binding Protein 10 From Bradysia odoriphaga (Diptera: Sciaridae) Binds Volatile Host Plant Compounds

Abstract Bradysia odoriphaga (Diptera: Sciaridae) is a major insect pest of seven plant families including 30 commercial crops in Asia. The long-term use of chemical pesticides leads to problems such as insect resistance, environmental issues, and food contamination. Against this background, a novel pest control method should be developed. In insects, odorant-binding proteins (OBPs) transport odor molecules, including pheromones and plant volatiles, to olfactory receptors. Here, we expressed and characterized the recombinant B. odoriphaga OBP BodoOBP10, observing that it could bind the sulfur-containing compounds diallyl disulfide and methyl allyl disulfide with Ki values of 8.01 μM and 7.00 μM, respectively. Homology modeling showed that the BodoOBP10 3D structure was similar to that of a typical OBP. Both diallyl disulfide and methyl allyl disulfide bound to the same site on BodoOBP10, mediated by interactions with six hydrophobic residues Met70, Ile75, Thr89, Met90, Leu93, and Leu94, and one aromatic residue, Phe143. Furthermore, silencing BodoOBP10 expression via RNAi significantly reduced the electroantennogram (EAG) response to diallyl disulfide and methyl allyl disulfide. These findings suggest that BodoOBP10 should be involved in the recognition and localization of host plants.
The effects of left dorsolateral prefrontal transcranial direct current stimulation on episodic future thinking following acute psychosocial stress

ABSTRACT Introduction Research on stress-related disorders and brain imaging suggests that (acute) stress might impact the capacity to mentally simulate specific episodic future events (EFT) through the effects of cortisol on brain regions supporting this cognitive function, such as the prefrontal cortices. This study aims to examine the mechanisms underlying this link, using transcranial Direct Current Stimulation (tDCS) over the left dorsolateral prefrontal cortex. Methods 60 healthy participants were subjected to the Montreal Imaging Stress Task (MIST), followed by either active or sham tDCS. After stimulation, the EFT task was administered. Salivary cortisol was measured throughout the protocol. Results Higher cortisol AUCi values were linked to less specific episodic future thoughts. Moreover, active tDCS enhanced EFT specificity irrespective of cortisol, especially in high trait ruminators. We did not observe an effect from active tDCS on cortisol AUCi, and equally there was no interaction effect between cortisol AUCi and stimulation condition predictive for EFT specificity. Conclusion Although we did not find evidence for the effects of tDCS on the HPA-system, our data reveal a crucial link between two critical predictors of mental health for the first time, and provide a solution to help rehabilitate EFT deficits. Trial registration: Netherlands National Trial Register identifier: ntr004.
Outcomes in pediatric anesthesia: towards a universal language

Purpose of review The identification of valid, well defined and relevant outcomes is fundamental to provide a reliable and replicable measure that can be used to improve quality of clinical care and research output. The purpose of this review is to provide an update on what the pediatric anesthesia research community is pursuing on standardized and validated outcomes. Recent findings Several initiatives by different research groups have been established during the last years. They all aim to find validated outcomes using the standardized methodology of COMET (https://www.comet-initiative.org/). These initiatives focus on clinical and research outcomes on the field of anesthesia, perioperative medicine, pain and sedation in pediatric age. Summary Clinical outcomes are measurements of changes in health, function or quality of life and they help evaluating quality of care. In order for them to be relevant in quantifying quality improvement, they need to be well defined, standardized and consistent across trials. A great effort from researchers has been made towards the identification of set of outcomes with these features.
Autobiographical memory and the self on the psychosis continuum: investigating their relationship with positive- and negative-like symptoms

ABSTRACT Autobiographical memory is severely impaired in schizophrenia, but previous work has largely treated both as unitary concepts. Here, we examined how various dimensions of autobiographical memory relate to different aspects of psychosis. Participants were recruited from the general population (Study 1, N = 264) and a university subject pool (Study 2, N = 305). We examined different measures of autobiographical memory and self (i.e., involuntary memory, autobiographical recollection, self-knowledge and self-awareness), at the trait level in Study 1 and both trait and state levels in Study 2, as a function of positive-and negative-like symptoms of psychosis. Across both studies, positive and negative dimensions of psychosis were found to be related to an increase in involuntary memories (i.e., the spontaneous recall of personal memories), and to lower self-concept clarity and insight. Positive and negative dimensions of psychosis correlated differently with autobiographical recollection characteristics, measured at both trait (Studies 1 and 2) and state levels (Study 2). Positive-like symptoms (in particular hallucination-proneness) showed a stronger and more consistent pattern of correlations than negative-like symptoms. These findings call for a dimensional approach to the relationship between autobiographical memory and psychosis symptoms in clinical and non-clinical individuals, to better understand the breakdown of autobiographical memory in the psychopathology of psychosis.