Miracle-dz/UniFAR-FTUs huggingface dataset:
Cortical thickness and inattention/hyperactivity symptoms in young children: a population-based study

Background. While many neuroimaging studies have investigated the neurobiological basis of attention deficit hyperactivity disorder (ADHD), few have studied the neurobiology of attention problems in the general population. The ability to pay attention falls along a continuum within the population, with children with ADHD at one extreme of the spectrum and, therefore, a dimensional perspective of evaluating attention problems has an added value to the existing literature. Our goal was to investigate the relationship between cortical thickness and inattention and hyperactivity symptoms in a large population of young children. Method. This study is embedded within the Generation R Study and includes 6- to 8-year-old children (n = 444) with parent-reported attention and hyperactivity measures and high-resolution structural imaging data. We investigated the relationship between cortical thickness across the entire brain and the Child Behavior Checklist Attention Deficit Hyperactivity Problems score. Results. We found that greater attention problems and hyperactivity were associated with a thinner right and left postcentral gyrus. When correcting for potential confounding factors and multiple testing, these associations remained significant. Conclusions. In a large, population-based sample we showed that young (6- to 8-year-old) children who show more attention problems and hyperactivity have a thinner cortex in the region of the right and left postcentral gyrus. The postcentral gyrus, being the primary somatosensory cortex, reaches its peak growth early in development. Therefore, the thinner cortex in this region may reflect either a deviation in cortical maturation or a failure to reach the same peak cortical thickness compared with children without attention or hyperactivity problems.
Statistical Inference, Distinguishability of Quantum States, And Quantum Entanglement

We argue from the point of view of statistical inference that the quantum relative entropy is a good measure for distinguishing between two quantum states (or two classes of quantum states) described by density matrices. We extend this notion to describe the amount of entanglement between two quantum systems from a statistical point of view. Our measure is independent of the number of entangled systems and their dimensionality.
Significance of the immune response to a major, conformational B-cell epitope on the hepatitis C virus NS3 region defined by a human monoclonal antibody

The nonstructural protein NS3 of hepatitis C virus (HCV) possesses two enzymatic domains which are thought to be essential for the virus life cycle: an N-terminal serine-type proteinase, responsible for the processing of nonstructural polypeptides, and a C-terminal nucleoside triphosphatase/helicase, presumably involved in the unwinding of the viral genome. The human antibody response to NS3 usually appears early in the course of HCV infection and is predominantly directed against the carboxyl-terminal portion; however, its fine specificity and clinical significance are largely unknown. We have generated a human monoclonal antibody (hMAb), designated CM3.B6, from a cloned B-cell line obtained from the peripheral blood of a patient with chronic HCV infection, which selectively recognized the purified NS3 protein expressed in bacteria or in eukaryotic cells transfected with full-length or NS3 cDNA. Fine-specificity studies revealed that CM3.B6 recognized a 92-amino-acid sequence (clone 8, amino acids 1363 to 1454) selected from an NS3 DNase fragment library but failed to bind to 12-mer peptides synthesized from the same region, suggesting recognition of a conformational B-cell epitope. Experiments using deletion mutants of clone 8 and competitive inhibition studies using a panel of NS3 peptide-specific murine MAbs indicated that limited N-terminal and C-terminal deletions resulted in a significant reduction of hMAb binding to clone 8, thus identifying a minimal antibody binding domain within clone 8. Competition experiments showed that binding of CM3.B6 to the NS3 protein was efficiently inhibited by 39 of 44 (89%) sera from HCV-infected patients, suggesting that the hMAb recognized an immunodominant epitope within the NS3 region. More importantly, recognition of the sequence defined by CM3.B6 appeared to accurately discriminate between viremic and nonviremic anti-HCV positive sera, suggesting potentially relevant clinical applications in the diagnosis and treatment of HCV infection.
Mindful movement and skilled attention

Bodily movement has long been employed as a foundation for cultivating mental skills such as attention, self-control or mindfulness, with recent studies documenting the positive impacts of mindful movement training, such as yoga and tai chi. A parallel “mind-body connection” has also been observed in many developmental disorders. We elaborate a spectrum of mindfulness by considering ADHD, in which deficient motor control correlates with impaired (disinhibited) behavioral control contributing to defining features of excessive distractibility and impulsivity. These data provide evidence for an important axis of variation for wellbeing, in which skillful cognitive control covaries with a capacity for skillful movement. We review empirical and theoretical literature on attention, cognitive control, mind wandering, mindfulness and skill learning, endorsing a model of skilled attention in which motor plans, attention, and executive goals are seen as mutually co-defining aspects of skilled behavior that are linked by reciprocal inhibitory and excitatory connections. Thus, any movement training should engage “higher-order” inhibition and selection and develop a repertoire of rehearsed procedures that coordinate goals, attention and motor plans. However, we propose that mindful movement practice may improve the functional quality of rehearsed procedures, cultivating a transferrable skill of attention. We adopt Langer’s spectrum of mindful learning that spans from “mindlessness” to engagement with the details of the present task and contrast this with the mental attitudes cultivated in standard mindfulness meditation. We particularly follow Feldenkrais’ suggestion that mindful learning of skills for organizing the body in movement might transfer to other forms of mental activity. The results of mindful movement training should be observed in multiple complementary measures, and may have tremendous potential benefit for individuals with ADHD and other populations.
BEHAVIORAL MUTANTS OF Drosophila ISOLATED BY COUNTERCURRENT DISTRIBUTION.

Complex as it is, much of the vast network of cellular functions has been successfully dissected, on a microscopic scale, by the use of mutants in which one element is altered at a time. A similar approach may be fruitful in tackling the complex structures and events underlying behavior, using behavioral mutations to indicate modifications of the nervous system. Drosophila offers the same advantages to such a study as it did to classical genetics, namely, large numbers and short generation time, to which may now be added an enormous store of accumulated knowledge concerning the organism. Containing about 105 neurons, the fly's nervous system is roughly halfway, on a logarithmic scale, between a single neuron and the human brain, and the fly is possessed of a rich repertoire of behavior. The considerable literature on Drosophila behavior since Carpenter's 1905 paper [1] has recently been reviewed by Manning. [2]
Large-scale network simulation techniques: examples of TCP and OSPF models

Simulation of large-scale networks remains to be a challenge, although various network simulators are in place. In this paper, we identify fundamental issues for large-scale networks simulation, and porpose new techniques that address them. First, we exploit optimistic parallel simulation techniques to enable fast execution on inexpensive hyper-threaded, multiprocessor systems. Second, we provide a compact, light-weight implementation framework that greatly reduces the amount of state required to simulate large-scale network models. Based on the proposed techniques, we provide sample simulation models for two networking protocols: TCP and OSPF. We implement these models in a simulation environment ROSSNet, which is an extension to the previously developed optimistic simulator ROSS. We perform validation experoments for TCP and OSPF and present performance reuslts of our techniques by simulating OSPF and TCP on a large and realistic topology, such as AT&T's US network based on rocketfuel data. The end result of these innovations is that we are able to simulate million node network tolopgies using inexpensive commercial off-the-shelf hyper-threaded multiprocessor systems consuming less than 1.4 GB of RAM in total.
Hyperforin Inhibits Akt1 Kinase Activity and Promotes Caspase-Mediated Apoptosis Involving Bad and Noxa Activation in Human Myeloid Tumor Cells

Background The natural phloroglucinol hyperforin HF displays anti-inflammatory and anti-tumoral properties of potential pharmacological interest. Acute myeloid leukemia (AML) cells abnormally proliferate and escape apoptosis. Herein, the effects and mechanisms of purified HF on AML cell dysfunction were investigated in AML cell lines defining distinct AML subfamilies and primary AML cells cultured ex vivo. Methodology and Results HF inhibited in a time- and concentration-dependent manner the growth of AML cell lines (U937, OCI-AML3, NB4, HL-60) by inducing apoptosis as evidenced by accumulation of sub-G1 population, phosphatidylserine externalization and DNA fragmentation. HF also induced apoptosis in primary AML blasts, whereas normal blood cells were not affected. The apoptotic process in U937 cells was accompanied by downregulation of anti-apoptotic Bcl-2, upregulation of pro-apoptotic Noxa, mitochondrial membrane depolarization, activation of procaspases and cleavage of the caspase substrate PARP-1. The general caspase inhibitor Z-VAD-fmk and the caspase-9- and -3-specific inhibitors, but not caspase-8 inhibitor, significantly attenuated apoptosis. HF-mediated apoptosis was associated with dephosphorylation of active Akt1 (at Ser473) and Akt1 substrate Bad (at Ser136) which activates Bad pro-apoptotic function. HF supppressed the kinase activity of Akt1, and combined treatment with the allosteric Akt1 inhibitor Akt-I-VIII significantly enhanced apoptosis of U937 cells. Significance Our data provide new evidence that HF's pro-apoptotic effect in AML cells involved inhibition of Akt1 signaling, mitochondria and Bcl-2 members dysfunctions, and activation of procaspases -9/-3. Combined interruption of mitochondrial and Akt1 pathways by HF may have implications for AML treatment.
Quasars, their host galaxies and their central black holes

We present the final results from our deep Hubble Space Telescope (HST) imaging study of the host galaxies of radio-quiet quasars (RQQs), radio-loud quasars (RLQs) and radio galaxies (RGs). We describe and analyse new Wide Field & Planetary Camera 2 (WFPC2) R-band observations for 14 objects, which when combined with the first tranche of HST imaging reported in McLure et al., provide a complete and consistent set of deep, red, line-free images for statistically matched samples of 13 RQQs, 10 RLQs and 10 RGs in the redshift band 0.1 < z < 0.25. We also report the results of new deep VLA imaging that has yielded a 5-GHz detection of all but one of the 33 active galactic nuclei (AGN) in our sample. Careful modelling of our images, aided by a high dynamic-range point spread function, has allowed us to determine accurately the morphology, luminosity, scalelength and axial ratio of every host galaxy in our sample. Armed with this information we have undertaken a detailed comparison of the properties of the hosts of these three types of powerful AGN, both internally and with the galaxy population in general. We find that spheroidal hosts become more prevalent with increasing nuclear luminosity such that, for nuclear luminosities MV < −23.5, the hosts of both radio-loud and radio-quiet AGN are virtually all massive ellipticals. Moreover, we demonstrate that the basic properties of these hosts are indistinguishable from those of quiescent, evolved, low-redshift ellipticals of comparable mass. This result rules out the possibility that radio-loudness is determined by host-galaxy morphology, and also sets severe constraints on evolutionary schemes that attempt to link low-z ultraluminous infrared galaxies with RQQs. Instead, we show that our results are as expected given the relationship between black hole and spheroid mass established for nearby galaxies, and apply this relation to estimate the mass of the black hole in each object. The results agree remarkably well with completely independent estimates based on nuclear emission-line widths; all the quasars in our sample have Mbh > 5 × 108 M⊙, while the radio-loud objects are confined to Mbh > 109 M⊙. This apparent mass-threshold difference, which provides a natural explanation for why RQQs outnumber RLQs by a factor of 10, appears to reflect the existence of a minimum and a maximum level of black hole radio output, which is a strong function of black hole mass (∝M2−2.5bh). Finally, we use our results to estimate the fraction of massive spheroids/black holes that produce quasar-level activity. This fraction is ≃0.1 per cent at the present day, rising to >10 per cent at z≃ 2–3.
Post-Synthetic Shaping of Porosity and Crystal Structure of Ln-Bipy-MOFs by Thermal Treatment

The reaction of anhydrous lanthanide chlorides together with 4,4′-bipyridine yields the MOFs ∞2[Ln2Cl6(bipy)3]·2bipy, with Ln = Pr − Yb, bipy = 4,4′-bipyridine, and ∞3[La2Cl6(bipy)5]·4bipy. Post-synthetic thermal treatment in combination with different vacuum conditions was successfully used to shape the porosity of the MOFs. In addition to the MOFs microporosity, a tuneable mesoporosity can be implemented depending on the treatment conditions as a surface morphological modification. Furthermore, thermal treatment without vacuum results in several identifiable crystalline high-temperature phases. Instead of collapse of the frameworks upon heating, further aggregation under release of bipy is observed. ∞3[LaCl3(bipy)] and ∞2[Ln3Cl9(bipy)3], with Ln = La, Pr, Sm, and ∞1[Ho2Cl6(bipy)2] were identified and characterized, which can also exhibit luminescence. Besides being released upon heating, the linker 4,4′-bipyridine can undergo activation of C-C bonding in ortho-position leading to the in-situ formation of 4,4′:2′,2′′:4′′,4′′′-quaterpyridine (qtpy). qtpy can thereby function as linker itself, as shown for the formation of the network ∞2[Gd2Cl6(qtpy)2(bipy)2]·bipy. Altogether, the manuscript elaborates the influence of thermal treatment beyond the usual activation procedures reported for MOFs.
Brain metabolism of branched‐chain amino acids

The synthesis of brain glutamate requires an amino group donor that is efficiently transported into the brain and that is readily transaminated. The branched‐chain amino acids (BCAA), particularly leucine, play this important role. The uptake of leucine across the blood‐brain barrier is faster than any other amino acid. Studies with 15N‐labelled branched‐chain amino acids indicate that at least one third of the amino groups of brain glutamate are derived from the BCAA; leucine alone probably donates at least 25%. Transamination occurs in large measure in astrocytes, which articulate closely with the brain capillaries across which amino acids must past as they are transported from the blood. After using BCAA nitrogen for glutamate synthesis, the astrocytes may release the branched‐chain ketoacid, e.g., α‐ketoisocaproate, to the extracellular fluid, from which it can be taken up in a neuronal compartment and there converted back to leucine. This process, which consumes an equimolar amount of glutamic acid, may provide a mechanism for the “buffering” of brain glutamate if levels of this excitatory (and potentially toxic) neurotransmitter become elevated. Leucine so formed in neurons is released to the extracellular fluid and transported back to the astrocytes, thereby completing a “leucine‐glutamate cycle. ” GLIA 21:92–98, 1997. © 1997 Wiley‐Liss, Inc.
Structural and transport properties of porous PVdF-HFP electrolyte membranes modified with an inorganic filler

Novel porous poly(vinylidene fluoride-hexafluoropropylene) (PVdF-HFP) copolymer membranes were prepared with zinc chloride as an additive and silica as a ceramic filler. Porosity of the membranes was determined by Scanning Electron Microscopy (SEM). Inclusion of ceramic filler decreases the crystalline character of a polymer which facilitates the movement of ions leading to an increase in the conductivity. The infra-red spectroscopic and EDX measurements revealed the presence of acid moieties in the composite membranes. The thermal stability of these blend membranes lies above 400°C, which is sufficiently high for use in DMFC. The membranes prepared for this study exhibited the ionic conductivity in the range of 10−3 to 10−2 S/cm and the methanol permeabilities ranged between 10−9 and 10−7cm2/s.
Challenges to the Transition to the Practical Application of IPMC as Artificial-Muscle Actuators

In recent years, electroactive polymers (EAP) materials have gained recognition as potential actuators with unique capabilities having the closest performance resemblance to biological muscles. Ion-exchange membrane metallic composites (IPMC) are one of the EAP materials with such a potential. The strong bending that is induced by IPMC offers attractive actuation for the construction of various mechanisms. Examples of applications that were conceived and investigated for planetary tasks include a gripper and wiper. The development of the wiper for dust removal from the window of a miniature rover, planned for launch to an asteroid, is the subject of this reported study. The application of EAP in space conditions is posing great challenge due to the harsh operating conditions that are involved and the critical need for robustness and durability. The various issues that can affect the application of IPMC were examined including operation in vacuum, low temperatures, and the effect of the electromechanical and ionic characteristics of IPMC on its actuation capability. The authors introduced highly efficient IPMC materials, mechanical modeling, unique elements and protective coatings in an effort to enhance the applicability of IPMC as an actuator of a planetary dust-wiper. Results showed that the IPMC technology is not ready yet for practical implementation due to residual deformation that is introduced under DC activation and the difficulty to protect the material ionic content over the needed 3-years durability. Further studies are under way to overcome these obstacles and other EAP materials are also being considered as alternative bending actuators.
Effect of iron deficiency and iron restoration on ultrastructure of Anacystis nidulans

The effects of iron deficiency and iron reconstitution on the ultrastructure of the unicellular cyanobacterium Anacystis nidulans R2 were studied by electron microscopy. Low-iron cells, grown with different amounts of aeration, were analyzed at 6, 12, and 24 h after the addition of iron. Low-iron cells had a decrease in the quantities of membranes, phycobilisomes, and carboxysomes and a large increase in glycogen storage granules. In cells aerated with gentle shaking, the addition of iron caused the number of carboxysomes to increase rapidly within 6 h. This was paralleled by a decrease in the quantity of glycogen storage granules. Carboxysomes were associated with the nucleoplasmic face of the inner photosynthetic membrane in normal, but not low-iron, cells; they once more contacted the membrane by 6 h after iron addition. Phycobilisome assembly was apparent by 6 h, and the number of phycobilisomes increased throughout reconstitution. Membrane restoration was accomplished in two stages: (i) components were added to preexisting membranes until about 12 h, and (ii) new membranes were synthesized beginning at 12 to 18 h. Low-iron cells grown by bubbling with air had only one to two concentric layers of membrane per cell. The addition of iron led to a pattern of reconstitution that was similar to that described above with two important exceptions. Under these conditions, the number of carboxysomes remained low and the carboxysomes rarely contacted the photosynthetic membranes. New membranes were not synthesized until the culture had reached the late-logarithmic growth phase and after all other morphological features had returned to normal.
Learning from Notes: organizational issues in groupware implementation

This paper explores the introduction of a groupware into an organization to understand the changes in work practices and social interaction facilitated by the technology. The results suggest that people's mental models and organizations' structure and culture significantly influence how groupware is implemented and used. Specifically, in the absence of mental models that stressed its collaborative nature, groupware was interpreted in terms of familiar personal, stand-alone technologies such as spreadsheets. Further, the culture and structure proved few incentives or norms for cooperating or sharing expertise, hence the groupware on its own was unlikely to engender collaboration. Recognizing the central influence of these cognitive and organizational elements is critical to developers, researchers, and practitioners of groupware.
Automatic configuration and run-time adaptation of distributed applications

Increased platform heterogeneity and varying resource availability in distributed systems motivates the design of resource-aware applications, which ensure a desired performance level by continuously adapting their behavior to changing resource characteristics. In this paper, we describe an application-independent adaptation framework that simplifies the design of resource-aware applications. This framework eliminates the need for adaptation decisions to be explicitly programmed into the application by relying on two novel components: (1) a tunability interface, which exposes adaptation choices in the form of alternate application configurations while encapsulating core application functionality, and (2) a virtual execution environment, which emulates application execution under diverse resource availability enabling off-line collection of information about the resulting behavior. Together, these components permit automatic run-time decisions on when to adapt by continuously monitoring resource conditions and application progress, and how to adapt by dynamically choosing the application configuration that is most appropriate for the prescribed user preference. We evaluate the framework using an interactive distributed image visualization application. The framework permits automatic adaptation to changes in CPU load and network bandwidth by choosing a different compression algorithm or by controlling the image transmission sequence so as to satisfy user preferences of visualization quality and timeliness.