Miracle-dz/UniFAR-FTUs huggingface dataset:
Relationship between paclitaxel activity and pathobiology of human solid tumors.

We previously reported the pharmacodynamics of antiproliferative and apoptotic effects of paclitaxel in histocultures of bladder, breast, head and neck, ovarian, and prostate tumors obtained from patients. This study examined the relationship between paclitaxel pharmacodynamics and tumor pathobiological parameters [i.e., stage, grade, proliferation status, expression of P-glycoprotein (Pgp), p53, and Bcl-2]. Pgp, p53, and Bcl-2 proteins were detected by immunohistochemical methods. The drug sensitivity rank order of the five tumor types is as follows: prostate > or = head and neck = bladder > breast > ovarian for the antiproliferative effect and breast = ovarian = head and neck > prostate = bladder for the apoptotic effect. When the pathobiological parameters were considered as single parameters, the antiproliferative effect was inversely correlated with tumor stage, grade, labeling index (LI), and expression of Pgp, p53, and Bcl-2 (P < 0.05 in all cases). The apoptotic effect was positively correlated with Pgp expression, LI, and tumor grade (P < 0.01) but was not related to tumor stage and expression of p53 and Bcl-2 (P > 0.2). Results of multivariate analysis indicated that the maximum antiproliferative effect was best predicted by the combination of tumor stage and expression of Pgp and p53 (inverse correlation) and that the maximum apoptotic effect was best predicted by the combination of tumor LI and Pgp expression (positive correlation). In summary, these results indicate that the two major effects of paclitaxel in human solid tumors, i.e., antiproliferation and apoptosis, correlate with different tumor properties. The second finding that drug-induced apoptosis was equal or higher in tumors that expressed Pgp, p53, and Bcl-2 compared to tumors that did not express these proteins supports the use of paclitaxel in treating Pgp-, p53- and Bcl-2-positive tumors.
Smita Rai Networks Darshan Thaker Architecture Jie Zhang Databases Fan Zhao Security Faculty Advisor Hao Chen Administrative Assistant Lisa Blackford

In recent years software security has gained significant interest in both academic circles and in the business community. This presentation examines software security from an industrial perspective. It looks at the origins of today's software security problems, the way that companies view software security, and the steps companies are taking to improve the security of the code they produce. Topics include methods for achieving code quality versus methods for achieving code security, approaches to measuring security, and a host of other problems that are in need of good solutions.
Temporal Phronesis in the Anthropocene

The situation in which we find ourselves—of potentially catastrophic global climate change—makes it clear why we need to move beyond a phenomenological approach to time to include evolutionary, historical, material, ecological and personal perspectives. This paper distinguishes ten different ways in which the complexity of time reveals itself to contemporary reflection. These patterns or shapes of time supply interpretive resources for the temporal phronesis needed to navigate the challenge of productively inheriting our many pasts, while thinking through and practically addressing the uncertain future both of our species, and indeed the planet.
The distance-based adaptive grouping protocol for heterogeneous wireless sensor networks

Wireless sensor networks (WSNs) are widely applied to many applications. Reducing energy consumption plays an important role in WSN. The concept of clustering is one of the popular energy-efficient protocols and it is applied to SEP, DEEC and SGCH technologies. Since the communication energy consumption depends on the communication distance, the communication distance and the residual energy of the sensor node should be considered for the clustering. In this paper, we propose a distance-based adaptive grouping protocol for the heterogeneous WSN. The energy and the distance of a group are used to generate the cluster head. This study compares the proposed method with LEACH, SEP, DEEC and SGCH with three-level heterogeneous WSN. The simulations also compare that the performances with the location of BS is outside and inside the WSN topology.
A new weighted centroid localization algorithm in wireless sensor networks

Nodes in a sensor network are often randomly distributed. To assign measurements to locations, each node has to determine its own position. Algorithms for positioning in wireless sensor networks are classified into two groups: approximate and exact. In this paper, we propose a range-based approximate positioning approach which is almost the combination of WCL and EBTB. Then, compare it with two other approximate positioning approaches (WCL with time complexity of O(n)) and EBTB with time complexity of O(n*n) and an exact positioning approach (QR Factorization with time complexity of O(n*n*n)). Finally, it will be shown that EWCL (with time complexity of O(n*n)) is the best localization algorithm with respect to the three other localization algorithms when the noise is high and its accuracy is close to the accuracy of QR when the noise is medium.
External Quality Assessment beyond the analytical phase: an Australian perspective

External Quality Assessment (EQA) is the verification, on a recurring basis, that laboratory results conform to expectations for the quality required for patient care. It is now widely recognised that both the pre- and post-laboratory phase of testing, termed the diagnostic phases, are a significant source of laboratory errors. These errors have a direct impact on both the effectiveness of the laboratory and patient safety. Despite this, Australian laboratories tend to be focussed on very narrow concepts of EQA, primarily surrounding test accuracy, with little in the way of EQA programs for the diagnostic phases. There is a wide range of possibilities for the development of EQA for the diagnostic phases in Australia, such as the utilisation of scenarios and health informatics. Such programs can also be supported through advances in health information and communications technology, including electronic test ordering and clinical decision support systems. While the development of such programs will require consultation and support from the referring doctors, and their format will need careful construction to ensure that the data collected is de-identified and provides education as well as useful and informative data, we believe that there is high value in the development of such programs. Therefore, it is our opinion that all pathology laboratories should strive to be involved in an EQA program in the diagnostic phases to both monitor the diagnostic process and to identify, learn from and reduce errors and near misses in these phases in a timely fashion.
sounding board Class — The Ignored Determinant of the Nation ’ s Health

The health of the American public has never been better. Infectious diseases that caused terror in families less than 100 years ago are now largely under control. With the important exception of AIDS and occasional outbreaks of new diseases such as the severe acute respiratory syndrome (SARS) or of old ones such as tuberculosis, infectious diseases no longer constitute much of a public health threat. Mortality rates from heart disease and stroke — two of the nation’s three major killers — have plummeted. It is no wonder that a 2003 Institute of Medicine report concluded that Americans today, as compared with those in 1900, “are healthier, live longer, and enjoy lives that are less likely to be marked by injuries, ill health, or premature death. ” 1
European Conference on Information Systems ( ECIS ) 5-15-2012 PRICE COMPARISON FOR INFRASTRUCTURE-ASA-SERVICE

Today’s pricing of infrastructure-as-a-service is not transparent because some providers, such as Google, charge separately for each service characteristic (e.g., $50 per CPU or $15 per GB of memory per month) and let customers freely configure the service. In contrast, competitors like Amazon, Microsoft, and IBM only offer predefined bundles (e.g., 4 GB of memory, 400 GB of storage, and 2 CPUs for $140 per month). These different types of pricing plans make price comparisons very difficult. The aim of this study is to increase price transparency among providers by analyzing two price comparison methods. The first method is the well-known "hedonic pricing", which decomposes each provider's billing into the contributing values of the product ́s characteristics. The second is a newly developed method, called PriCo ("Pricing plan Comparison"), which in addition considers offers from competitive providers. We employ the two methods in an empirical study, which compares the pricing of the infrastructure-as-a-service providers Google, Microsoft, Amazon, IBM, and Terremark. The insights gained help customers to better identify the least expensive provider for their needs. The proposed methods also help providers to better understand and position their pricing in the market.
Molecular insights into the origin of the Hox-TALE patterning system

Despite tremendous body form diversity in nature, bilaterian animals share common sets of developmental genes that display conserved expression patterns in the embryo. Among them are the Hox genes, which define different identities along the anterior–posterior axis. Hox proteins exert their function by interaction with TALE transcription factors. Hox and TALE members are also present in some but not all non-bilaterian phyla, raising the question of how Hox–TALE interactions evolved to provide positional information. By using proteins from unicellular and multicellular lineages, we showed that these networks emerged from an ancestral generic motif present in Hox and other related protein families. Interestingly, Hox-TALE networks experienced additional and extensive molecular innovations that were likely crucial for differentiating Hox functions along body plans. Together our results highlight how homeobox gene families evolved during eukaryote evolution to eventually constitute a major patterning system in Eumetazoans. DOI: http://dx.doi. org/10.7554/eLife.01939. 001
SentiWordSKOS: A lexical ontology extended with sentiments and emotions

With the Web 2.0, the user is become an active part of the global network, by interacting with other people through social networks, blogs, etc. and posting his own comments. The importance of user opinions and relative sentiments and emotions is undiscussed. Companies and organizations monitor blog sites to catch the consumers' opinions about their products and services and then improve their marketing and business plans. In an effort to explore potential resolutions to this issue, the recent research proceeds towards the “distillation” of the social knowledge, in order to capture the moods that govern the users' behavior on the Web. In the light of these observations, this paper presents SentiWordSKOS, a lightweight ontology which provides a concept-based representation of sentiments and emotions. SentiWordSKOS integrates data from WordNet (describing natural language words) and SentiWordNet (associating a polarity to words) in order to get a mapping between words and sentiments. In addition, each word sense is further associated with a set of the emotions, according to the “Hourglass of Emotions”, a sentic levels based model, used to describe emotions.
Non-vanishing of the twisted cohomology on the complement of hypersurfaces

Generically, the cohomology with coefficients in a local system of rank one on the complement in P" of the union of a finite number of hypersurfaces vanishes except in the highest dimension. We study the non-generic case, in which the cohomology in other dimensions does not vanish. When the hypersurfaces are hyperplanes, many examples of this kind are known. In this paper, we consider the case in which the hypersurfaces need not be hyperplanes. We prove that the hypersurfaces given by some particular linear systems have non-vanishing local system cohomologies.
Putting holes in holey geometry

This paper presents a method for computing topology changes for triangle meshes in an interactive geometric modeling environment. Most triangle meshes in practice do not exhibit desirable geometric properties, so we develop a solution that is independent of standard assumptions and robust to geometric errors. Specifically, we provide the first method for topology change applicable to arbitrary non-solid, non-manifold, non-closed, self-intersecting surfaces. We prove that this new method for topology change produces the expected conventional results when applied to solid (closed, manifold, non-self-intersecting) surfaces---that is, we prove a backwards-compatibility property relative to prior work. Beyond solid surfaces, we present empirical evidence that our method remains tolerant to a variety of surface aberrations through the incorporation of a novel error correction scheme. Finally, we demonstrate how topology change applied to non-solid objects enables wholly new and useful behaviors.
On the selection of passive elements for low phase noise LC tank VCO in 65 nm process

This paper describes the LC tank design for low phase noise LC VCO on the selection of passive elements. LC tank based VCO is commonly used for the low phase noise performance in most RF applications. Since quality factor of the LC tank is mainly dominated by the quality factor of the passive elements (inductor & capacitor) selection, this work presents the passive elements optimization based on the inductor and varactor optimization. Simulated in 65 nm process, higher Q is obtained for large width and minimum number of turns for the inductor and for the varactor design; the PMOS varactor operating in the depletion and accumulation regions allows large tuning range and less parasitic resistance.
SpineMan: Design of a soft robotic spine-like manipulator for safe human-robot interaction

Robots made from soft materials have recently captured the interest of researchers from a range of fields including engineers, material scientists, and chemists, biologists, and computer scientists. This new paradigm of soft robotics aims to develop more adaptable, more capable and safer robots that can interact with unstructured environments or permit close cooperation with humans. Current, commercially-available solutions in industrial robotics tend to take a software-centered approach to safe human-robot interaction or focus on the design of lightweight structures consisting of conventional rigid materials. Even though these solutions provide a higher safety level than traditional industrial robots, robots that comprise a sufficiently large amount of soft structures will bring about a certain degree of inherent safety. One of the major challenges in today's soft robotics research is to design robots that are inherently safe and adaptable but are also capable of bearing limited loads. Nature has solved this predicament in larger animals by incorporating stiff endoskeletons, which support the weight of the otherwise predominantly soft bodies. This insight has led to the development of a novel spine-like manipulator (SpineMan) comprised of rigid elements made from polypropylene and soft elements consisting of polyvinyl alcohol (PVA) borax hydrogels that are enveloped in a silicone skin. The initial design, material selection, synthesis, and characterization of this robot are presented in this article.
Evaluating x86 condition codes impact on superscalar execution

The design of instruction sets is a fundamental aspect of computer architecture. A critical requirement of instruction set design is to allow for concurrent execution, avoiding those constructs that may produce data dependencies among instructions. Therefore, it is important to count on methods and tools for the evaluation of the behavior of instruction sets and quantify the influence of particular features of its architecture into the overall available parallelism. We propose an analysis method that applies graph theory to gather metrics to evaluate the impact of different characteristics of instruction sets as sources of coupling thus quantifying available parallelism. We present a case study using the x86 instruction set and obtain some measures of the influence of condition flags in code coupling.
Profiling Dose-Dependent Activation of p53-Mediated Signaling Pathways by Chemicals with Distinct Mechanisms of DNA Damage

As part of a larger effort to provide proof-of-concept in vitro-only risk assessments, we have developed a suite of high-throughput assays for key readouts in the p53 DNA damage response toxicity pathway: double-strand break DNA damage (p-H2AX), permanent chromosomal damage (micronuclei), p53 activation, p53 transcriptional activity, and cell fate (cell cycle arrest, apoptosis, micronuclei). Dose-response studies were performed with these protein and cell fate assays, together with whole genome transcriptomics, for three prototype chemicals: etoposide, quercetin, and methyl methanesulfonate. Data were collected in a human cell line expressing wild-type p53 (HT1080) and results were confirmed in a second p53 competent cell line (HCT 116). At chemical concentrations causing similar increases in p53 protein expression, p53-mediated protein expression and cellular processes showed substantial chemical-specific differences. These chemical-specific differences in the p53 transcriptional response appear to be determined by augmentation of the p53 response by co-regulators. More importantly, dose-response data for each of the chemicals indicate that the p53 transcriptional response does not prevent micronuclei induction at low concentrations. In fact, the no observed effect levels and benchmark doses for micronuclei induction were less than or equal to those for p53-mediated gene transcription regardless of the test chemical, indicating that p53's post-translational responses may be more important than transcriptional activation in the response to low dose DNA damage. This effort demonstrates the process of defining key assays required for a pathway-based, in vitro-only risk assessment, using the p53-mediated DNA damage response pathway as a prototype.
Handling Constraints for Search Based Software Test Data Generation

A major issue in software testing is the automatic generation of the inputs to be applied to the programme under test. To solve this problem, a number of approaches based on search methods have been developed in the last few years, offering promising results for adequacy criteria like, for instance, branch coverage. We devise branch coverage as the satisfaction of a number of constraints. This allows to formulate the test data generation as a constrained optimisation problem or as a constraint satisfaction problem. Then, we can see that many of the generators so far have followed the same particular approach. Furthermore, this constraint-handling point of view overcomes this limitation and opens the door to new designs and search strategies that, to the best of our knowledge, have not been considered yet. As a case study, we develop test data generators employing different penalty objective functions or multiobjective optimisation. The results of the conducted preliminary experiments suggest these generators can improve the performance of classical approaches.
Pulse Width Evolution in Gamma-Ray Bursts: Evidence for Internal Shocks

Many cosmological models of gamma-ray bursts (GRBs) envision the energy source to be a cataclysmic stellar event leading to a relativistically expanding fireball. Particles are thought to be accelerated at shocks and produce nonthermal radiation. The highly variable temporal structure observed in most GRBs has significantly constrained models. By using different methods of statistical analysis in the time domain, we find that the width of the large-amplitude pulses in GRB time histories remains remarkably constant throughout the classic GRB phase. This is also true for small-amplitude pulses. However, small and large pulses do not have the same pulse width within a single time history. We find a quantitative relationship between pulse amplitude and pulse width: the smaller amplitude peaks tend to be wider, with the pulse width following a power law with an index of about -2.8. Internal shocks simulated by randomly selecting the Lorentz factor and energy per shell are consistent with a power-law relationship. This is strong quantitative evidence that GRBs are indeed caused by internal shocks. The dependency of the width-versus-intensity relationship on the maximum Lorentz factor provides a way to estimate that elusive parameter. Our observed power-law index indicates that Γmax is ≲103. We also interpret the narrowness of the pulse width distribution as indicating that the emission that occurs when one shell overtakes another is produced over a small range of distances from the central site.
The mesoderm of the amphibian embryo forms from the equatorial region of the late blastula in response to signals derived from the vegetal hemisphere of the embryo

INTRODUCTION The mesoderm of the amphibian embryo forms from the equatorial region of the late blastula in response to signals derived from the vegetal hemisphere of the embryo (Heasman, 2006). These signals include members of the transforming growth factor type β (TGF-β) Two significant characteristics of these signals are that they can act at long range and that they behave as morphogens, eliciting different responses at different concentrations. These properties raise the question of how such molecules exert their long-range effects: what route do they take to traverse a field of responding cells? This question has been addressed for TGF-β family members in several developing systems, and particularly in the Drosophila imaginal disc, where one proposal is that long-range signalling by Decapentaplegic (Dpp) occurs in this epithelial tissue by transcytosis (Entchev et al., 2000; Gonzalez-Gaitan and Jackle, 1999). According to this model, Dpp released by signalling cells would be taken up by adjacent cells by endocytosis, and after traversing these cells it would be released by exocytosis further away from the source, for the process then to be repeated. Although the data supporting transcytosis in Drosophila has been reinterpreted to suggest that Dpp exerts its long-range effects by diffusion (Belenkaya et al., 2004; Lander, 2007), endocytosis has been shown to play a role in regulating the range of Fgf8 signalling in the
IMPACT OF PARENT-IMPLEMENTED CONTINGENT IMITATION ON YOUNG CHILDREN AT-RISK FOR ASD

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by pervasive deficits in social orienting and social engagement. Research suggests that parent-implemented interventions using responsive interactive techniques may be effective to increase social engagement in very young children with ASD, although more work is needed to examine how best to support a responsive parental style in this exceptionally heterogeneous population. Emerging evidence indicates that contingent imitation (CI) may be uniquely effective to increase social engagement in children with ASD. This study used a multiple-baseline-across-participants single case design to examine how three caregivers learned to use CI at home with fidelity with their young children at risk for ASD, how use of CI was associated with changes in directive adult behaviors and to identify associated changes in child social engagement and eye gaze. Results demonstrate that caregivers quickly acquired the accurate use of this simple technique at home and sharply reduced their use of questions and directives during play sessions. Child social engagement levels and social eye gaze demonstrated positive changes across intervention and maintenance phases. Implications for research and early intervention practice are discussed.