Miracle-dz/UniFAR-FTUs huggingface dataset:
Use of Laser Capture Microdissection to Map HCV-Positive Hepatocytes in Human Liver

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Cognitive Behaviour Therapy

This study explores the phenomenological experience of rumination in a sample of 22 chronically depressed people and looks at the extent to which it is consistent with theoretical ideas. The findings indicate that, on average, depressed people ruminate about at least two different topics, and that there is wide variability in how long each episode lasts. Rumination is a complex process frequently involving imagery as well as verbal thoughts and is almost invariably associated with multiple emotions. Although there was some evidence for stop rules being involved, most individuals attributed ending a period of rumination to distraction, whether external or internally generated.
Joint inversion of strong motion, teleseismic, geodetic, and tsunami datasets for the rupture process of the 2011 Tohoku earthquake

The 2011 Tohoku earthquake was observed by dense strong motion, teleseismic, geodetic, and tsunami networks. We first inverted each of the datasets obtained by the networks separately, for the rupture process of the earthquake. We then performed checkerboard resolution tests for assessing the resolving power of these datasets. In order to overcome the limited resolutions of the separate inversions and differences in their results, we performed a quadruple joint inversion of all these data to determine a source model most suitable for explaining all the datasets. In the obtained source model, the maximum coseismic slip was approximately 35 m, and the total seismic moment was calculated to be 4.2 × 1022 Nm, which yielded Mw = 9.0. The main rupture propagated not only in the strike direction but also in the dip direction and included both the deep area called the Miyagi‐oki region and the compact shallow area near the Japan Trench.
Pembangunan Basis Data Guna Lahan Kabupaten Bengkalis

ABSTRAK Penelitian ini bertujuan untuk membangun basis data untuk pengembangan sistem informasi penggunaan lahan di wilayah kota/kabupaten dengan mengambil studi kasus di Kabupaten Bengkalis. Basis data yang dibangun diharapkan dapat membantu para pengambil kebijakan dalam kegiatan analisis penataan ruang dan pengelolaan lahan. Dalam melaksanakan analisis spasial, digunakan komponen-komponen analisis spasial yang terdapat dalam SIG di antaranya adalah: overlay, buffer, dan intersection. Basis data yang dibangun dalam penelitian ini selain dapat berfungsi sebagai media penyimpanan data spasial, juga dapat berfungsi sebagai alat untuk menganalisis daerah-daerah dalam rencana pola ruang yang memiliki risiko terhadap banjir, menganalisis daerah-daerah yang berpotensi sengketa dalam kaitannya dengan pemanfaatan hutan, serta menganalisis kawasan-kawasan suaka alam yang dimanfaatkan tidak sebagaimana fungsi utamanya. Kata kunci: Basis data, sistem informasi, penggunaan lahan, analisis spasial, penataan ruang. ABSTRACT The purpose of this research is to build a database for the development of information system of land use in Bengkalis Regency that can help decision-makers in spatial analysis activities and land management. In conducting spatial analysis, this study used spatial analysis components contained in the GIS include: overlay, buffer, and intersection. The conclusion that can be drawn from this study is that the system can serve as a spatial data storage media. Moreover this system can also serve as a tool to analyze the areas in the landuse plan that has the spatial patterns of flood risks, to analyze the areas that have the potential dispute in relation to forest use, as well as analyzing the nature reserve areas that are not used as its primary function. Keywords: Database, Information System, land use, spatial analysis, spatial plan.
Sperm head morphology is associated with sperm swimming 1 speed : a comparative study of songbirds using electron 2 microscopy

5 Sperm exhibit extraordinary levels of morphological diversification across the animal 6 kingdom. In songbirds, sperm have a helically shaped head incorporating a distinct acrosomal 7 membrane or ‘helical keel’, the form and extent of which varies across species. The functional 8 significance of this helical shape, however, remains unknown. Using scanning electron 9 microscopy, we quantified interand intra-specific variation in sperm head morphology 10 across 36 songbird species (Passeriformes: Passerida). Using phylogenetic comparative 11 methods, we investigated the relationship between sperm head morphology and both sperm 12 swimming speed and the frequency of extra-pair young (EPY). We found that species whose 13 sperm had a relatively more pronounced helical form (i.e. long acrosome, short nucleus, wide 14 helical membrane, and a more pronounced waveform along the sperm head ‘core’) had faster15 swimming sperm. We found no evidence of a relationship between inter-specific variation in 16 sperm head morphology and EPY, although we did find that amongand within-male 17 variation in sperm head traits were negatively correlated with EPY. Applying principles of 18 fluid mechanics, we discuss how the helical form of the sperm head may influence swimming 19 speed, and suggest that further studies considering aspects of sperm morphology beyond 20 sperm length are needed to improve our understanding of sperm structure-function 21 relationships. 22
Physiologic and nanoscale distinctions define glutamatergic synapses in tonic vs phasic neurons

Neurons exhibit a striking degree of functional diversity, each one tuned to the needs of the circuitry in which it is embedded. A fundamental functional dichotomy occurs in activity patterns, with some neurons firing at a relatively constant “tonic” rate, while others fire in bursts - a “phasic” pattern. Synapses formed by tonic vs phasic neurons are also functionally differentiated, yet the bases of their distinctive properties remain enigmatic. A major challenge towards illuminating the synaptic differences between tonic and phasic neurons is the difficulty in isolating their physiological properties. At the Drosophila neuromuscular junction (NMJ), most muscle fibers are co-innervated by two motor neurons, the tonic “MN-Ib” and phasic “MN-Is”. Here, we employed selective expression of a newly developed botulinum neurotoxin (BoNT-C) transgene to silence tonic or phasic motor neurons. This approach revealed major differences in their neurotransmitter release properties, including probability, short-term plasticity, and vesicle pools. Furthermore, Ca2+ imaging demonstrated ~two-fold greater Ca2+ influx at phasic neuron release sites relative to tonic, along with enhanced synaptic vesicle coupling. Finally, confocal and super resolution imaging revealed that phasic neuron release sites are organized in a more compact arrangement, with enhanced stoichiometry of voltage-gated Ca2+ channels relative to other active zone scaffolds. These data suggest that distinctions in active zone nano-architecture and Ca2+ influx collaborate to differentially tune glutamate release at synapses of tonic vs phasic neuronal subtypes.
Adaptive but Non-Optimal Visual Search Behavior in Highlighted Displays

Previous research has suggested that making certain items visually salient, or highlighting, can speed performance in a visual search task. But designers of interfaces cannot always easily anticipate a user’s target, and highlighting items other than the target can be associated with performance decrements. An experiment performed suggested that people attend to highlighting less than what an optimal model of visual search in highlighted displays predicts. Users’ sensitivity to highlighting’s predictiveness depends upon the proportion of trials in which highlighting actually predicts target location. We constructed an ACT-R model that reproduces the major effects of the experiment and which suggests that learning occurs at a very low level of this task.
Factors Influencing Unsafe Behaviors and Accidents on Construction Sites : A Review

Factors Influencing Unsafe Behaviors and Accidents on Construction Sites: A Review Yahya Khosravi, Hassan Asilian-Mahabadi, Ebrahim Hajizadeh, Narmin Hassanzadeh-Rangi, Hamid Bastani & Amir H. Behzadan a Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran b Occupational Health Research Center (OHRC), Iran University of Medical Sciences, Tehran, Iran c Health, Safety and Environment Management, MAPNA Group Co., Tehran, Iran d Department of Civil, Environmental, and Construction Engineering, University of Central Florida, Orlando, USA Published online: 08 Jan 2015.
Wave propagation in laterally varying media and iterative inversion for velocity

The Gaussian beam method of Cerveny et. al. [1982] is an asymptotic method for the computation of wavefields in inhomogeneous media. The method consists of tracing rays and then solving the wave equation in "ray-centered coordinates. " The parabolic approximation is applied to find the asymptotic local solution in the neighborhood of each ray. The approximate global solution for a given source is then constructed by a superposition of Gaussian beams along nearby 'rays. The Gaussian beam method is tested in a 2-D inhomogeneous medium using two approaches. One is the application of the reciprocal theorem for Green's functions in an arbitrarily heterogeneous medium. The discrepancy between synthetic seismograms for reciprocal cases is considered as a measure of the error. The other approach is to apply Gaussian beam synthesis to cases for which solutions are known by other approximate methods. This includes the soft basin problem which has been studied by finite difference, finite element, discrete wavenumber, and glorified optics. We found that the results of these tests were in general satisfactory. We have used the Gaussian beam method for two applications. First, the method is used to study volcanic earthquakes at Mt. St. Helens. The observed large differences in amplitude and arrival time between a station inside the crater and stations on the flanks can be explained by the combined effects of an anomalous velocity structure and a shallow focal depth. The method is also applied to scattering of teleseismic P-waves by a lithosphere with randomly
Importance Sampling for the Infinite Sites Model

Importance sampling or Markov Chain Monte Carlo sampling is required for state-of-the-art statistical analysis of population genetics data. The applicability of these sampling-based inference techniques depends crucially on the proposal distribution. In this paper, we discuss importance sampling for the infinite sites model. The infinite sites assumption is attractive because it constraints the number of possible genealogies, thereby allowing for the analysis of larger data sets. We recall the Griffiths-Tavaré and Stephens-Donnelly proposals and emphasize the relation between the latter proposal and exact sampling from the infinite alleles model. We also introduce a new proposal that takes knowledge of the ancestral state into account. The new proposal is derived from a new result on exact sampling from a single site. The methods are illustrated on simulated data sets and the data considered in Griffiths and Tavaré (1994).
Use of Kinase Inhibitors to Correct (cid:1) F508-CFTR Function*

The most common mutation in cystic fibrosis (CF) is a deletion of Phe at position 508 ( (cid:1) F508-CFTR). (cid:1) F508-CFTR is a trafficking mutant that is retained in the ER, unable to reach the plasma membrane. To identify compounds and drugs that rescue this trafficking defect, we screened a kinase inhibitor library enriched for small molecules already in the clinic or in clinical trials for the treatment of cancer and inflammation, using our recently developed high-content screen technology (Trzcinska-Daneluti et al. Mol. Cell. Proteomics 8:780, 2009). The top hits of the screen were further validated by (1) biochemical analysis to demonstrate the presence of mature (Band C) (cid:1) F508-CFTR, (2) flow cytometry to reveal the presence of (cid:1) F508-CFTR at the cell surface, (3) short-circuit current (I sc ) analysis in Ussing chambers to show restoration of function of the rescued (cid:1) F508-CFTR in epithelial MDCK cells stably expressing this mutant (including EC 50 deter-minations), and importantly (4) I sc analysis of Human Bronchial Epithelial (HBE) cells harvested from homozygote (cid:1) F508-CFTR transplant patients. Interestingly, several inhibitors of receptor Tyr kinases (RTKs), such as SU5402 and SU6668 (which target FGFRs, VEGFR, and PDGFR) exhibited strong rescue of (cid:1) F508-CFTR, as did several inhibitors of the Ras/Raf/MEK/ERK or p38 pathways
Can additional patient experience items improve the reliability of and add new domains to the CAHPS hospital survey?

CONTEXT The Centers for Medicare and Medicaid Services will introduce the reporting of patient surveys in 2008. The Consumer Assessment of Health Care Providers and Systems (CAHPS) Hospital Survey contains 18 questions about hospital care. Internal consistency reliability of the discharge information scale is relatively low and some important domains of care are not represented. OBJECTIVE To determine whether adding questions increases the reliability and validity of the survey. DATA SOURCES AND STUDY SETTING Surveys of patients at 181 hospitals participating in the California Hospitals Assessment and Reporting Taskforce (CHART), an initiative for voluntary public reporting of hospital performance in California. STUDY DESIGN CHART added nine questions to the CAHPS Hospital Survey; two to improve reliability of the discharge information domain, five to create a coordination of care domain, and two relating to interpreter services. DATA COLLECTION Surveys were sent to randomly selected patients from each CHART hospital. PRINCIPAL FINDINGS A total of 40,172 surveys were included. Adding the new discharge information questions improved the internal consistency reliability from 0.45 to 0.72 and the hospital-level reliability from 0.75 to 0.81. New coordination of care composites had good internal consistency reliabilities ranging from 0.58 to 0.70 and hospital-level reliabilities ranging from 0.84 to 0.87. The new coordination of care composites were more closely correlated with overall hospital ratings and willingness to recommend than six of the seven original domains. CONCLUSIONS The additional discharge information questions and the new coordination of care questions significantly improved the psychometric properties of the CAHPS Hospital Survey.
Broad‐scale applicability of correlation detectors to China seismicity

It is demonstrated that cross‐correlation methods can successfully be applied on a large scale to the detection of seismic events arising in a variety of tectonic settings. The locations of about thousand earthquakes a year occurring in and near China are reported using phase picks from a large national network. We performed more than 100 million cross correlations on the waveforms of more than 18,800 events over 20 years, as recorded by a relatively sparse network; and detected about two thirds of the nationally reported events. Additional events (70% increase), beyond what standard processing detects for China on the sparse network, were also found. A corresponding reduction in detection threshold approaches 0.9 magnitude units for increasing station distance. As networks densify and archives grow, cross‐correlation is likely to become more and more useful for purposes of maximizing the number of detected events and hence to improve knowledge of seismicity.
Policy Implementation of Marine Protected Areas Program in Indonesia: a Case Study of The Marine Recreational Park of Gili Meno, Gili Ayer, and Gili Trawangan, West Nusa Tenggara, Indonesia

Abstra ct This paper examines TWP Gili Matra as a case study to illustrate the current situation of MPAs in Indonesia. It will use qualitative approach to discuss the extant government policies through key informant interviews and reviews of documents with the consideration of different factors that impede such program which was then analyzed using the policy implementation analysis framework developed by Najam (1995). The result of the study shows that implementation of MPAs policy in TWP Gili Matra has not well implemented yet because of some constraining factors explained by the Najam’s framework. Thus, it need several clear action to be considered in suppressing such constraining factors and improving supporting factor of the management and development of TWP Gili Matra. Keywords: policy implementation, TWP Gili Matra, 5C Protocol, Marine Protected Area
Vision-Based Parking-Slot Detection: A Benchmark and A Learning-Based Approach

Recent years have witnessed a growing interest in developing automatic parking systems in the field of intelligent vehicles. However, how to effectively and efficiently locating parking-slots using a vision-based system is still an unresolved issue. Even more seriously, there is no publicly available labeled benchmark dataset for tuning and testing parking-slot detection algorithms. In this paper, we attempt to fill the above-mentioned research gaps to some extent and our contributions are twofold. Firstly, to facilitate the study of vision-based parking-slot detection, a large-scale parking-slot image database is established. This database comprises 8600 surround-view images collected from typical indoor and outdoor parking sites. For each image in this database, the marking-points and parking-slots are carefully labeled. Such a database can serve as a benchmark to design and validate parking-slot detection algorithms. Secondly, a learning-based parking-slot detection approach, namely P S D L , is proposed. Using P S D L , given a surround-view image, the marking-points will be detected first and then the valid parking-slots can be inferred. The efficacy and efficiency of P S D L have been corroborated on our database. It is expected that P S D L can serve as a baseline when the other researchers develop more sophisticated methods.
Erosional marks on consolidated banks and slump blocks in the Rupen River, north‐west India

Erosional marks, including grooves, current crescents and flutes, are present on banks and slump blocks of the Rupen River on the semi‐arid plains of north‐west India. The channel has a width:depth ratio of 6, and is incised up to 8 m through well consolidated, fine‐grained aeolian sediment dated at ∼ 20–60 ka. Pedogenic carbonate nodules embedded in the channel walls have localized scour, and reworked carbonate particles probably promoted corrasion during strong seasonal flow. Similar erosional marks are apparently scarce on modern river banks, and a distinctive combination of conditions, including a consolidated substrate and strong flow in a confined channel, is probably required for their generation and preservation on channel walls and on slump blocks.
mediates the effects of disturbance on ant structure.

local ant assemblages, we examined whether climate mediates the effects of habitat disturbance on assemblage structure at a global scale. Species richness and evenness were associated positively with temperature, and negatively with disturbance. However, the interaction among temperature, precipitation and disturbance shaped species richness and evenness. The effect was manifested through afailure of species richnessto increase substantially with temperature in transformed habitats at low precipitation. At low precipitation levels, evenness increased with temperature in undisturbed sites, peaked at medium temperatures in disturbed sites and remained low in transformed sites. In warmer climates with lower rainfall, the effects of increasing disturbance on species richness and evenness were akin to decreases in temperature of up to 9 8 C. Anthropogenic disturbance and ongoing climate change may interact in complicated ways to shape the structure of assemblages, with hot, arid environments likely to be at greatest risk. model. For a subset of the data where we had more detailed information on the type of disturbance ( n ¼ 755), we also tested models where fire-affected sites were excluded, because the absence of fire might be considered a disturbance in highly fire-prone biomes. Additionally, we examined models where low latitudes ( 2 17 8 to 17 8 ) were excluded, because transformed sites were not represented within that range.
PILE-CAP-PILE-GROUP INTERACTION IN NONHOMOGENEOUS SOIL

A numerical method of analysis is presented to study the behavior of vertically loaded pile groups embedded in a nonhomogencous soil with the pile caps in contact with the ground. The considered soil profiles consist of soil with Young's moduli increasing linearly with depth. Parametric solutions are presented to show the influence of the distribution of the soil Young's moduli on the behavior of the groups. For the nonhomogeneous‐soil profiles considered, the effect of the cap in contact with the ground has a small influence on the stiffness of the group compared to the case without a ground‐contacting cap. The load carried by the cap, as expected, is significantly affected by the distribution of the soil Young's moduli. Case studies of field tests in clay show that the consideration of the nature of the soil inhomogeneity at the sites better models the behavior of pile groups with ground‐contacting caps.
Use of colloidal gold particles in double-labeling immunoelectron microscopy of ultrathin frozen tissue sections

Complexes of protein-A with 5 and 16 nm colloidal gold particles (PA/Au5 and PA/Au16) are presented as sensitive and clean immunoprobes for ultrathin frozen sections of slightly fixed tissue. The probes are suitable for indirect labeling and offer the opportunity to mark multiple sites. The best procedure for double labeling was to use the smaller probe first, i.e., antibody 1 - PA/Au5 - antibody 2 - PA/Au16. When this was done, no significant interference between PA/Au5 and PA/Au16 occurred. Using this double-labeling procedure we made an accurate comparison between the subcellular distributions of amylase as a typical secretory protein and of GP-2 a glycoprotein, characteristic for zymogen granule membrane (ZGM) preparations. We prepared two rabbit antibodies against GP-2. One antibody (R x ZGM) was obtained by immunizing with native membrane material. The specificity of R x ZGM was achieved by adsorption with the zymogen granule content subfraction. The other, R x GP-2, was raised against the GP-2 band of the SDS polyacrylamide profile of ZGM. We found that the carbohydrate moiety of GP-2 was involved in the antigenic determinant for R x ZGM, while R x GP-2 was most likely directed against GP-2 polypeptide backbone. THe immunocytochemical observations showed that GP-2, on the one hand, exhibited the characteristics of a membrane protein by its occurrence in the cell membrane, the Golgi membranes, and its association with the membranes of the zymogen granules. On the other hand, GP-2 was present in the contents of the zymogen granules and in the acinar and ductal lumina. Also, a GP-2-like glycoprotein was found in the cannulated pancreatic secretion (Scheffer et al., 1980, Eur. J. Cell Biol. 23:122-128). Hence, GP-2 should be considered as a membrane- associated secretory protein of the rat pancreas.