Miracle-dz/UniFAR-FTUs huggingface dataset:
Host-dependence of Trivalent Erbium (Er3+) Spectra Relevant to Solid-state Lasers: Yttrium Aluminum Garnet (YAG) and Sesquioxides

Abstract : The U.S. Army Research Laboratory is developing technologies for power-scalable solid-state lasers operating at cryogenic temperatures. We have particular interest in operation at wavelengths that present the least risk of ocular damage, resulting in considerable focus on trivalent erbium (Er3+). We have carried out extensive comparisons of the spectra of Er3+ in two particularly promising types of oxide crystals: yttrium aluminum garnet (YAG) and various cubic sesquioxides. This report presents many of the principal results of this study. Er:YAG has more favorable properties for room-temperature laser operation, but some Er-doped sesquioxides appear more advantageous for operation at and near liquid nitrogen temperature.
Association between alcohol consumption and rotator cuff tear

Background and purpose — Long-term alcohol intake is associated with various negative effects on capillary microcirculation and tissue perfusion. We hypothesized that alcohol consumption might be a risk factor for both the occurrence and the severity of rotator cuff tears (RCTs). Patients and methods — A case-control study was performed. We studied 249 consecutive patients (139 men and 110 women; mean age 64 (54–78) years) who underwent arthroscopic rotator cuff repair. Tear size was determined intraoperatively. The control group had 356 subjects (186 men and 170 women; mean age 66 (58–82) years) with no RCT. All participants were questioned about their alcohol intake. Participants were divided into: (1) non-drinkers if they consumed less than 0.01 g of ethanol per day, and (2) moderate drinkers and (3) excessive drinkers if women (men) consumed > 24 g (36 g) per day for at least 2 years. Results — Total alcohol consumption, wine consumption, and duration of alcohol intake were higher in both men and women with RCT than in both men and women in the control group. Excessive alcohol consumption was found to be a risk factor for the occurrence of RCT in both sexes (men: OR = 1.7, 95% CI: 1.2–3.9; women: OR = 1.9, 95% CI: 0.94–4.1). Massive tears were associated with a higher intake of alcohol (especially wine) than smaller lesions. Interpretation — Long-term alcohol intake is a significant risk factor for the occurrence and severity of rotator cuff tear in both sexes.
Current-sensor-based feed cutting force intelligent estimation and tool wear condition monitoring

Tool wear condition monitoring has the potential to play a critical role in ensuring the dimensional accuracy of the workpiece and prevention of damage to cutting equipment. It could also help in automating cutting processes. In this paper, the feed cutting force estimated with the aid of an inexpensive current sensor installed on the AC servomotor of a computerized numerical control tuning center is used to monitor tool wear condition. To achieve this, the feed drive system is modeled, using neuro-fuzzy techniques, to provide the framework for estimating the feed cutting force based on the feed motor current measured. Functional dependence of the feed cutting force on tool wear and cutting parameters are then expressed in the form of a difference equation relating variation in the feed cutting force to tool wear rate. The computerized system automatically compares successive feed cutting force estimates and determines the onset of accelerated tool wear in order to issue a request for tool replacement. Experimental results show that the tool wear condition monitoring is effective and industrially applicable.
The Applied Pi Calculus

We study the interaction of the programming construct “new,” which generates statically scoped names, with communication via messages on channels. This interaction is crucial in security protocols, which are the main motivating examples for our work; it also appears in other programming-language contexts. We define the applied pi calculus, a simple, general extension of the pi calculus in which values can be formed from names via the application of built-in functions, subject to equations, and be sent as messages. (In contrast, the pure pi calculus lacks built-in functions; its only messages are atomic names.) We develop semantics and proof techniques for this extended language and apply them in reasoning about security protocols. This article essentially subsumes the conference paper that introduced the applied pi calculus in 2001. It fills gaps, incorporates improvements, and further explains and studies the applied pi calculus. Since 2001, the applied pi calculus has been the basis for much further work, described in many research publications and sometimes embodied in useful software, such as the tool ProVerif, which relies on the applied pi calculus to support the specification and automatic analysis of security protocols. Although this article does not aim to be a complete review of the subject, it benefits from that further work and provides better foundations for some of it. In particular, the applied pi calculus has evolved through its implementation in ProVerif, and the present definition reflects that evolution.
The human-computer interaction spiral

Multidisciplinary collaboration is essential for effective human computer interaction. Historically computer science, psychology and the social sciences have operated as discreet disciplines. However with the increased use of Information communication technologies in everyday life issues of appropriate design, functionality and accessibility assume increased importance. In this paper a model for effective multidisciplinary human-computer interaction (HCI) is presented. This is an interactive spiral that informs science through the integration of observations, reflections, theories and practices across a diverse range of disciplines. Informed multidisciplinary responses increase the likelihood of appropriate design solutions. Case studies in tertiary education and mental health are used to illustrate the application of the HCI spiral for ongoing multidisciplinary collaboration in HCI design.
Model Driven Design of Distribution Patterns forWeb Service Compositions

Increasingly, distributed systems are being constructed by composing a number of discrete components. This practice, termed composition, is particularly prevalent within the Web service domain. Here, enterprise systems are built from many existing discrete applications, often legacy applications exposed using Web service interfaces. There are a number of architectural configurations or distribution patterns, which express how a composed system is to be deployed. However, the amount of code required to realise these distribution patterns is considerable. In this paper, we propose a novel Model Driven Architecture using UML 2.0, which takes existing Web service interfaces as its input and generates an executable Web service composition, based on a distribution pattern chosen by the software architect.
Comparison of industrial WSN standards

This paper presents a comparison of the current Wireless Sensor Network (WSN) standards that are available for industrial applications. Zigbee, WirelessHART and the recently released ISA.100 are carefully considered. The comparison outlines how WirelessHART and ISA.100 address some of the ZigBee weaknesses in the oil and gas domain.
Neurofeedback and Serious Games

Neuroscience as well as computer gaming have rapidly advanced in the last decades. Yet, the combination of both fields is still in its infancy. One example of an emerging alliance is neurofeedback, where participants are required to learn controlling their own brain activity. So far, this kind of training is mostly applied in therapeutic settings, for example improving symptoms in epilepsy, attention-deficit/ hyperactivity disorder, or autism spectrum disorder. However, there are some promising approaches that used neurofeedback in everyday situations for healthy subjects. This may prove especially valuable for serious games that aim to improve learning capabilities and cognitive aspects of individual users. The following chapter introduces the basic concepts and standards of neurofeedback. The different non-invasive imaging techniques are introduced along with successful applications in neurofeedback. Finally, benefits and pitfalls for future combinations of neurofeedback and games are discussed: while the former may profit from realistic and motivating video scenarios, the latter is expected to be a tool for evaluating and monitoring the direct effects on the user’s brain.
Review of recent epidemiological studies on paternal occupations and birth defects

The main findings reported by recent epidemiological studies on paternal occupations and birth defects are reviewed, and the main limitations associated with these studies discussed. Epidemiological studies on paternal occupations and birth defects were reviewed for the period 1989 to 1999 inclusive. Systematic searches were made with search engines with related keywords. There were several common paternal occupations that were repeatedly reported to be associated with birth defects. These paternal occupations were janitors, painters, printers, and occupations exposed to solvents; fire fighters or firemen; and occupations related to agriculture. The common weaknesses in most of these studies include inaccurate assessment of exposures, different classification systems, different inclusion criteria of birth defects, and low statistical power. It is concluded that epidemiological studies, reported in the past decade, suggest that several common paternal occupations are associated with birth defects. Future studies could be focused on these specific, rather than general, occupational groups so that causative agents may be confirmed and thus enable appropriate preventive measures to be taken.
DC-Voltage-Ratio Control Strategy for Multilevel Cascaded Converters Fed With a Single DC Source

Recently, a multilevel cascaded converter fed with a single DC source has been presented. An analysis of the steady-state working limits of this type of converter is presented in this paper. Limits of the maximum output voltage and the minimum and maximum loading conditions for stable operation of the converter are addressed. In this paper, a way to achieve any DC voltage ratio (inside the stable operation area of the converter) between the H-bridges of the single-DC-source cascaded H-bridge converter is presented. The proposed DC-voltage-ratio control is based on a time-domain modulation strategy that avoids the use of inappropriate states to achieve the DC-voltage-ratio control. The proposed technique is a feedforward-modulation technique which takes into account the actual DC voltage of each H-bridge of the converter, leading to output waveforms with low distortion. In this way, the dc voltage of the floating H-bridge can be controlled while the output voltage has low distortion independently of the desired DC voltage ratio. Experimental results from a two-cell cascaded converter are presented in order to validate the proposed DC-voltage-ratio control strategy and the introduced concepts.
Ethanol consumption and pineal melatonin daily profile in rats

It is well known that melatonin participates in the regulation of many important physiological functions such as sleep–wakefulness cycle, motor coordination and neural plasticity, and cognition. However, as there are contradictory results regarding the melatonin production diurnal profile under alcohol consumption, the aim of this paper was to study the phenomenology and mechanisms of the putative modifications on the daily profile of melatonin production in rats submitted to chronic alcohol intake. The present results show that rats receiving 10% ethanol in drinking water for 35 days display an altered daily profile of melatonin production, with a phase delay and a reduction in the nocturnal peak. This can be partially explained by a loss of the daily rhythm and the 25% reduction in tryptophan hydroxylase activity and, mainly, by a phase delay in arylalkylamine N‐acetyltransferase gene expression and a 70% reduction in its peak activity. Upstream in the melatonin synthesis pathway, the results showed that noradrenergic signaling is impaired as well, with a decrease in β1 and α1 adrenergic receptors' mRNA contents and in vitro sustained loss of noradrenergic‐stimulated melatonin production by glands from alcohol‐treated rats. Together, these results confirm the alterations in the daily melatonin profile of alcoholic rats and suggest the possible mechanisms for the observed melatonin synthesis modification.
Implementation of Linear Filters for Iterative Penalized Maximum Likelihood SPECT Reconstruction

11. THEORY were implemented for iterative penalized maximumdetection process is well known [l-31: Six low-pass linear filters applied in frequency space The log likelihood of a Poisson distributed photonlikelihood (ML) SPECT image reconstruction. The filters implemented were the Shepp-Logan filter, the Butterworth filter, the Gaussian'filter, the Hann filter, the ParZen filter, and the Lagrange filter. The low-pass filtering was applied in frequency space to projection data for the initial estimate and to the difference of projection data and reprojected data for higher order approximations. The projection data were acquired experimentally from a chest phantom consisting of non-uniform attenuating media. All the filters could effectively remove the noise and edge artifacts associated with ML approach if the frequency cutoff was properly chosen. The improved performance of the M e n and Lagrange filters relative to the others was observed. The best image, by viewing its profiles in terms of noise-smoothing, edge-sharpening, and contrast, was the one obtained with the M e n filter. However, the Lagrange filter has the potential to consider the characteristics of detector response function.
Effector Proteins for Methylated Histones: An Expanding Family

Methylation of histone lysine residues in eukaryotic chromatin has been an exciting area of research ever since the first histone methyltransferase enzyme, Suv39h, was found to methylate lysine 9 of histone H3 in 2000 1. Only a year later, the HP1 chromodomain polypeptide was identified as a recognition module for this histone modification 2, 3. Similar to bromodomain-containing proteins that recognize histone acetylation sites and subsequently stabilize large complexes to chromatin, effector proteins can also be recruited and stabilized by histone methylation. Although histone acetylation generally correlates with active transcription, histone methylation is associated with both the activation and silencing of transcription, depending on which lysine residue is modified. The list of proteins that may in fact directly associate with specific methylated histone lysines is expanding. Since the finding of HP1, many additional proteins have been shown to bind methylated histone residues. For instance, Polycomb, Chd1, 53BP1, and Crb2/Rad9 proteins all associate with methylated chromatin in a unique manner governed by their respective recognition motifs. Here we highlight recent data on the recognition specificity and biological significance of proteins that associate with methylated histone lysines.
Identifying a Highly-Aggressive DCIS Subgroup by Studying Intra-Individual DCIS Heterogeneity among Invasive Breast Cancer Patients

The heterogeneity among multiple ductal carcinoma in situ (DCIS) lesions within the same patient also diagnosed with invasive ductal carcinoma (IDC) has not been well evaluated, leaving research implications of intra-individual DCIS heterogeneity yet to be explored. In this study formalin-fixed paraffin embedded sections from 36 patients concurrently diagnosed with DCIS and IDC were evaluated by immunohistochemistry. Ten DCIS lesions from each patient were then randomly selected and scored. Our results showed that expression of PR, HER2, Ki-67, and p16 varied significantly within DCIS lesions from a single patient (P<0.05 for PR; P<1×10−8 for HER2, Ki-67 and p16). In addition, seventy-two percent of the individuals had heterogeneous expression of at least 2/6 markers. Importantly, by evaluating the expression of promising DCIS risk biomarkers (Ki-67, p53 and p16) among different DCIS subgroups classified by comparing DCIS molecular subtypes with those of adjacent normal terminal duct lobular units (TDLU) and IDC, our results suggest the existence of a highly-aggressive DCIS subgroup, which had the same molecular subtype as the adjacent IDC but not the same subtype as the adjacent normal TDLU. By using a systematic approach, our results clearly demonstrate that intra-individual heterogeneity in DCIS is very common in patients concurrently diagnosed with IDC. Our novel findings of a DCIS subpopulation with aggressive characteristics will provide a new paradigm for mechanistic studies of breast tumor progression and also have broad implications for prevention research as heterogeneous pre-invasive lesions are present in many other cancer types.
Risk factors for hamstring muscle strain injury in sport: a systematic review and meta-analysis

Hamstring muscle strain-type injuries are common in sports that involve sprinting,1 acceleration, deceleration, rapid change in direction and jumping.2 ,3 Occurring in both recreational and professional sports, these injuries can result in substantial time lost from sport and commonly recur.4 ,5 In the Australian Football League (AFL), hamstring muscle strain-type injuries have displayed a high incidence rate, with a 10 year mean of 6.1 new injuries per club each year and a 23% average recurrence rate.6 A recurrence rate of 17% has been reported in elite soccer players7 with hamstring injuries also recorded as the most common injury accounting for 12% of all injuries and resulting in an average of four missed games per injury.8 The high incidence of hamstring muscle strain-type injuries and potential associated costs has resulted in a substantial amount of research into the factors related to such injuries. Two recent systematic reviews have been completed in an attempt to collate the evidence around risk factors for hamstring injuries.9 ,10 Both reviews identified hamstring muscle weakness and thigh muscle imbalance, muscle flexibility, previous hamstring injury, other previous injury and age as potential risk factors; however, these reviews concluded that single variables were inconsistently identified as associated factors. Both reviews provided a qualitative synthesis of the literature and included risk factor studies as well as intervention studies, where a potential risk factor was modified with a training programme. The inclusion of intervention studies may potentially complicate risk factor analyses, as such studies assume that the factor being modified is associated with the injury and that the factor can be modified by the treatment programme. The aim of the current review was to assemble all available knowledge and data to identify the intrinsic and extrinsic risk factors associated with …
Human Ether-à-go-go–related Gene K+ Channel Gating Probed with Extracellular Ca2+

Human ether-à-go-go–related gene (HERG) encoded K+ channels were expressed in Chinese hamster ovary (CHO-K1) cells and studied by whole-cell voltage clamp in the presence of varied extracellular Ca2+ concentrations and physiological external K+. Elevation of external Ca2+ from 1.8 to 10 mM resulted in a reduction of whole-cell K+ current amplitude, slowed activation kinetics, and an increased rate of deactivation. The midpoint of the voltage dependence of activation was also shifted +22.3 ± 2.5 mV to more depolarized potentials. In contrast, the kinetics and voltage dependence of channel inactivation were hardly affected by increased extracellular Ca2+. Neither Ca2+ screening of diffuse membrane surface charges nor open channel block could explain these changes. However, selective changes in the voltage-dependent activation, but not inactivation gating, account for the effects of Ca2+ on Human ether-à-go-go–related gene current amplitude and kinetics. The differential effects of extracellular Ca2+ on the activation and inactivation gating indicate that these processes have distinct voltage-sensing mechanisms. Thus, Ca2+ appears to directly interact with externally accessible channel residues to alter the membrane potential detected by the activation voltage sensor, yet Ca2+ binding to this site is ineffective in modifying the inactivation gating machinery.
Rab4 and Rab7 Define Distinct Nonoverlapping Endosomal Compartments*

Several Rab GTPases have been localized to distinct compartments of the endocytic pathway. Rab4 is associated with early endosomes and recycling vesicles and regulates membrane recycling from early endosomes. Rab7 is localized to late endosomes and is involved in the regulation of membrane transport between late endosomes and lysosomes. Although Rab4 and Rab7 appear to regulate distinct transport events in endocytosis, it is not clear whether they perform their activities in related or entirely distinct intracellular compartments. To address this question, we generated stable cell lines expressing Rab4 tagged with a novel X31 influenza hemagglutinin (NH) epitope tag. These antibodies are characterized in this paper and were used to immunoisolate endocytic vesicles with cytoplasmically exposed NHRab4. Immunoisolated membranes contain internalized 125I-transferrin, but are devoid of Rab7. Confocal immunofluorescence microscopy showed that the early endosomal GTPases Rab4 and Rab5 both do not codistribute with Rab7 within the same cell. These observations suggest that each of the three Rab GTPases operationally defines a distinct station of the endocytic pathway.
Advanced channel engineering achieving aggressive reduction of VT variation for ultra-low-power applications

We have achieved aggressive reduction of V<inf>T</inf> variation and V<inf>DD-min</inf> by a sophisticated planar bulk MOSFET named ‘Deeply Depleted Channel ™ (DDC)’. The DDC transistor has been successfully integrated into an existing 65nm CMOS platform by combining layered channel formation and low temperature processing. The 2x reduction of V<inf>T</inf> variation in 65nm-node has been demonstrated by matching SRAM pair transistors, 2x improvement in SRAM static noise margin (SNM) and 300 mV V<inf>DD-min</inf> reduction of 576Kb SRAM macros to 0.425 V using conventional 6T cell layout.
Communicative Functions Integrate Segments in Prosodies and Prosodies in Segments

Abstract This paper takes a new look at the traditionally established divide between sounds and prosodies, viewing it as a useful heuristics in language descriptions that focus on the segmental make- up of words. It pleads for a new approach that bridges this reified compartmentalization of speech in a more global communicative perspective. Data are presented from a German perception experiment in the framework of the Semantic Differential that shows interdependence of f0 contours and the spectral characteristics of a following fricative segment, for the expression of semantic functions along the scales questioning – asserting, excited – calm, forceful – not forceful, contrary – agreeable. The results lead to the conclusion that segments shape prosodies and are shaped by them in varying ways in the coding of semantic functions. This implies that the analysis of sentence prosodies needs to integrate the manifestation of segments, just as the analysis of segments needs to consider their prosodic embedding. In communicative interaction, speakers set broad prosodic time windows of varying sizes, and listeners respond to them. So, future phonetic research needs to concentrate on speech analysis in such windows.