Miracle-dz/UniFAR-FTUs huggingface dataset:
Evidence on the effects of exercise therapy in the treatment of chronic disease

Evidence on the effects of exercise in the treatment of patients with chronic diseases should be based on well designed randomised controlled trials. The most consistent finding of the meta-analyses summarised in the present work is that aerobic/functional capacity and muscle strength can be improved by exercise training among patients with different diseases without having detrimental effects on disease progression. This is important, as with population aging exercise therapy may be an important means of reducing disability and increasing the number of older people living independently. Additionally, there is accumulating evidence that in patients with chronic disease exercise therapy is effective in improving the prognostic risk factor profile and, in certain diseases, in delaying mortality. In some diseases, such as osteoarthritis, pain symptoms may also be reduced. Severe complications during the exercise therapy programs were rare.
“Follow the Leader”: A Centrality Guided Clustering and Its Application to Social Network Analysis

Within graph theory and network analysis, centrality of a vertex measures the relative importance of a vertex within a graph. The centrality plays key role in network analysis and has been widely studied using different methods. Inspired by the idea of vertex centrality, a novel centrality guided clustering (CGC) is proposed in this paper. Different from traditional clustering methods which usually choose the initial center of a cluster randomly, the CGC clustering algorithm starts from a “LEADER”—a vertex with the highest centrality score—and a new “member” is added into the same cluster as the “LEADER” when some criterion is satisfied. The CGC algorithm also supports overlapping membership. Experiments on three benchmark social network data sets are presented and the results indicate that the proposed CGC algorithm works well in social network clustering.
A novel attribute-based signcryption scheme in cloud computing environments

In this paper, a novel decentralized key-policy attribute-based signcryption scheme is proposed, where the decentralized authority A can generate an attribute-based key pair for the sensitive data owner independently. In the proposed scheme, the sensitive data owner can share sensitive data through specifying an attribute-based access control structure so that any users whose attributes satisfy it can be allowed to access the sensitive data without knowing the sensitive data owner's unique identity information. Therefore, it is clear that the decentralized authority can reduce the communication cost and the collaborative cost. Additionally, the decentralized key-policy attribute-based signcryption scheme is efficient in terms of both the security communication and identification authentication, and can realize security sensitive data sharing for valid users in cloud computing environments.
Conditionnel et ultériorité dans le passé : de la subjectivité à l'objectivité

Comment signifier, au niveau du verbe, qu’un proces B, est, dans le PASSE, ulterieur a un proces A ? Le francais, comme beaucoup d’autres langues, notamment les autres idiomes romans, a developpe, parallelement a l’expression verbo-temporelle de l’ulteriorite du PRESENT (viendra, va / doit venir), une expression verbo-temporelle de l’ulteriorite du PASSE (viendrait / allait/ devait venir) : (1) Pierre me dit que Corinne viendra / va/ doit venir me voir. (2) Pierre m’a dit que Corinne viendrait / allait/ devait venir me voir. Dans les deux cas, l’ulteriorite prend appui sur une enonciation, mais differemment : - l’ulteriorite du PRESENT (1) s’organise deictiquement a partir du nunc de l’acte d’enonciation du locuteur-enonciateur. Le proces est pose dans le FUTUR. - l’ulteriorite du PASSE (2) s’organise a partir du tunc d’un acte d’enonciation anterieur realise par un enonciateur secondaire – en (2) le dire de Corinne – et rapporte par le locuteur-enonciateur. C’est a partir de ce tunc que le proces est construit en ulteriorite anaphoriquement, ce qui rend compte de ce qu’il puisse referer a un evenement anterieur, contemporain ou posterieur au nunc. On a donc dans les deux cas une ulteriorite subjective, deictique pour le futur, et anaphorique pour le conditionnel. La dissymetrie dans la symetrie ne s’arrete pas la : a la difference de l’ulteriorite du PRESENT qui est toujours subjective, le francais est parvenu a developper une ulteriorite objective dans le PASSE a partir des formes verbo-temporelles subjectives de cette epoque : conditionnel, allait / devait + inf. (et egalement a partir des formes de l’ulteriorite du PRESENT, cf. le futur dit historique) : (3) L’ete 43 chassa la petite famille de la maison aux toits d’ardoise. Beaucoup plus tard, les enfants regretteraient (allaient / devaient regretter) les cerisiers, les buissons drus ou ils enfouissaient des cabanes. (.) (Chaix, Les Lauriers du lac de Constance, 1974) La communication analyse precisement par quel chemin de grammaticalisation une forme qui au depart signifie l’ulteriorite subjective comme le conditionnel peut parvenir a entrer dans la production d’un enonce dans lequel le proces apparait bien comme ulterieur mais objectivement ; s’inscrit non dans la ramification de l’ulteriorite mais dans l’unilinearite du PASSE ; et implique non la suspension du jugement epistemique du locuteur (comme en (2), mais, par inference, l’engagement dans la factualite, ce que teste son possible remplacement par un passe simple (regretterent).
Conjugated anionic PEG-citrate G2 dendrimer with multi-epitopic HIV-1 vaccine candidate enhance the cellular immune responses in mice

Abstract Multi-epitope vaccines might cause immunity against multiple antigenic targets. Four immunodominant epitopes of HIV-1 genome were used to construct a polytope vaccine, formulated by dendrimer. Two regimens of polytopes mixture with dendrimer were utilized to immunize BALB/c mice. Adjuvants were also used to boost immune responses. The conjugated polytope could arouse significant cellular immune responses (P < 0.05) and Th1 response showed higher intensity compared to Th2 (P < 0.05). Our study depicted that conjugated dendrimer with multi-epitopic rHIVtop4 would efficiently induce cell-mediated immune responses and might be considered as promising delivery system for vaccines formulation.
Fast facial expression recognition for emotion awareness disposal

This paper presents a simple and fast expression recognition algorithm aimed at running in a secondary plane to provide emotion awareness for primary applications as e.g. exergames, in real time. The algorithm is based on the extraction of 19 facial landmarks which are used to detect some of the Action Units (AUs) defined in the Facial Action Coding System (FACS) and a newly created one. In addition, the new concept of Combined Action Units (CAUs) is presented. Those are grouped AUs which are detected as a unit. The applied emotion classification is based on logical rules, no learning is involved. First implementations have been made on a mobile platform.
Unifying Recursion Schemes

Folds over inductive datatypes are well understood and widely used. In their plain form, they are quite restricted; but many disparate generalisations have been proposed that enjoy similar calculational benefits. There have also been attempts to unify the various generalisations: two prominent such unifications are the ‘recursion schemes from comonads’ of Uustalu, Vene and Pardo, and our own ‘adjoint folds’. Until now, these two unified schemes have appeared incompatible. We show that this appearance is illusory: in fact, adjoint folds subsume recursion schemes from comonads. The proof of this claim involves standard constructions in category theory that are nevertheless not well known in functional programming: Eilenberg-Moore categories and bialgebras. The link between the two schemes is provided by the fusion rule of categorical fixedpoint calculus.
Immediate outcomes of eptifibatide therapy during intracoronary stent implantation

Background: The objective of the present study was to assess the major immediate outcomes of eptifibatide therapy during intracoronary stent implantation. Materials and Methods: In an interventional study, patients undergoing percutaneous coronary intervention (PCI) were randomized into either the eptifibatide (n = 100) or the control (n = 107) group. In each group, demographic and clinical characteristics such as cardiac death, stent thrombosis (ST), myocardial infarction (MI), rates of target lesion and vessel revascularization, cerebral vascular accident (CVA), and emergency coronary artery bypass grafting (CABG) were recorded. Results: The overall rates of major adverse events such as mortality, Stent thrombosis (ST), Myocardial Infarction (MI), target lesion revascularization (TLR), target vessel revascularization (TVR), CVA, and emergency CABG within 24 h after stent implantation were low and comparable between the two groups; P > 0.05 considered significant for all comparisons. Conclusion: There were no statistical differences between the clinical outcomes of groups administered with single-dose intracoronary eptifibatide and control groups among patients undergoing PCI during stent implantation.
Efficient Classifier Training to Minimize False Merges in Electron Microscopy Segmentation

The prospect of neural reconstruction from Electron Microscopy (EM) images has been elucidated by the automatic segmentation algorithms. Although segmentation algorithms eliminate the necessity of tracing the neurons by hand, significant manual effort is still essential for correcting the mistakes they make. A considerable amount of human labor is also required for annotating groundtruth volumes for training the classifiers of a segmentation framework. It is critically important to diminish the dependence on human interaction in the overall reconstruction system. This study proposes a novel classifier training algorithm for EM segmentation aimed to reduce the amount of manual effort demanded by the groundtruth annotation and error refinement tasks. Instead of using an exhaustive pixel level groundtruth, an active learning algorithm is proposed for sparse labeling of pixel and boundaries of superpixels. Because over-segmentation errors are in general more tolerable and easier to correct than the under-segmentation errors, our algorithm is designed to prioritize minimization of false-merges over false-split mistakes. Our experiments on both 2D and 3D data suggest that the proposed method yields segmentation outputs that are more amenable to neural reconstruction than those of existing methods.
HER2 amplification in recurrent breast cancer following breast‐conserving therapy correlates with distant metastasis and poor survival

The authors analyzed the HER2 status in early‐stage nonrecurrent and recurrent breast cancer groups following breast‐conserving treatment. Retrospective analyses of a group of 36 invasive early breast cancer (IBC) patients who developed a local recurrence as a first event and of a random control group of 69 IBC patients were made. HER2 status was assessed by the HercepTest® (Dako Corp., Carpinteria, CA) and fluorescence in situ hybridization. The Kaplan–Meier proportional log‐rank test was used to study the impact of the biological factors on the metastasis‐free interval (MFI) and the overall survival (OS). The Cox proportional hazards model, using stepwise selection was performed to identify the independent predictors of poor outcome. The median time of follow‐up was 156 months (range: 22–230) for the nonrecurrent group of patients and 119 months (range: 36–228) for the recurrent group. No significant differences between either group were observed in terms of either patient or tumor characteristics, or of HER2 expression. However, a higher proportion of HER2 amplified cases were found in the recurrent group, in contrast to a higher proportion of hormonal receptor positive cases in the nonrecurrent group. After univariate and multivariate analyses, HER2 amplification was found to be an independent predictive factor for distant metastasis (HR = 10.75; p = 0.00008) and for survival (HR = 4.22; p = 0.004). In conclusion, HER2 amplification constitutes an independent poor prognostic factor for the MFI and OS in patients with recurrent breast cancer. The clinical implications are discussed. © 2005 Wiley‐Liss, Inc.
Starvation-induced Cleavage of the tRNA Anticodon Loop in Tetrahymena thermophila*

Amino acid deprivation triggers dramatic physiological responses in all organisms, altering both the synthesis and destruction of RNA and protein. Here we describe, using the ciliate Tetrahymena thermophila, a previously unidentified response to amino acid deprivation in which mature transfer RNA (tRNA) is cleaved in the anticodon loop. We observed that anticodon loop cleavage affects a small fraction of most or all tRNA sequences. Accumulation of cleaved tRNA is temporally coordinated with the morphological and metabolic changes of adaptation to starvation. The starvation-induced endonucleolytic cleavage activity targets tRNAs that have undergone maturation by 5′ and 3′ end processing and base modification. Curiously, the majority of cleaved tRNAs lack the 3′ terminal CCA nucleotides required for aminoacylation. Starvation-induced tRNA cleavage is inhibited in the presence of essential amino acids, independent of the persistence of other starvation-induced responses. Our findings suggest that anticodon loop cleavage may reduce the accumulation of uncharged tRNAs as part of a specific response induced by amino acid starvation.
The Medial Prefrontal Cortex and the Emergence of Self-Conscious Emotion in Adolescence

In the present study, we examined the relationship between developmental modulation of socioaffective brain systems and adolescents’ preoccupation with social evaluation. Child, adolescent, and adult participants viewed cues indicating that a camera was alternately off, warming up, or projecting their image to a peer during the acquisition of behavioral-, autonomic-, and neural-response (functional MRI) data. Believing that a peer was actively watching them was sufficient to induce self-conscious emotion that rose in magnitude from childhood to adolescence and partially subsided into adulthood. Autonomic arousal was uniquely heightened in adolescents. These behavioral patterns were paralleled by emergent engagement of the medial prefrontal cortex (MPFC) and striatum-MPFC connectivity during adolescence, which are thought to promote motivated social behavior in adolescence. These findings demonstrate that adolescents’ self-consciousness is related to age-dependent sensitivity of brain systems critical to socioaffective processes. Further, unique interactions between the MPFC and striatum may provide a mechanism by which social-evaluation contexts influence adolescent behavior.
Interleukin (IL)-15 and IL-7 Jointly Regulate Homeostatic Proliferation of Memory Phenotype CD8+ Cells but Are Not Required for Memory Phenotype CD4+ Cells

The overall size and composition of the pool of naive and memory T cells are tightly regulated by homeostatic mechanisms. Recent work has shown that homeostasis of naive T cells is controlled by two factors, self-major histocompatibility complex (MHC)/peptide ligands and a cytokine, interleukin (IL)-7. In particular, contact with these two factors is required for naive CD4+ and CD8+ cells to undergo “homeostatic” proliferation, i.e., proliferation induced as a consequence of severe T cell depletion. In contrast to naive T cells, the factors that drive memory T cells to undergo homeostatic proliferation are poorly understood. To address this issue, purified memory phenotype CD4+ and CD8+ cells from normal mice were adoptively transferred into various gene-knockout mice rendered T cell–deficient by sublethal irradiation. Three findings are reported. First, unlike naive T cells, homeostatic proliferation of memory T cells is largely MHC independent. Second, memory CD8+ cells can utilize either IL-7 or IL-15 to undergo homeostatic proliferation; however, in the absence of both IL-7 and IL-15, homeostatic proliferation fails to occur. Third, unlike memory CD8+ cells, homeostatic proliferation of memory CD4+ cells is independent of IL-7 and IL-15 (also IL-4). Thus, the homeostatic proliferation mechanisms that control memory CD8+ cells and memory CD4+ cells are quite distinct.
Adjuvant targeted therapy in early breast cancer

For this review, the authors appraised the evidence for adjuvant trastuzumab therapy in early breast cancer. There was level 1 evidence to support the routine use of 1 year of adjuvant trastuzumab in conjunction with chemotherapy for women with human epidermal growth factor receptor 2 (HER‐2)‐positive early breast cancer. The relative benefits of concurrent versus sequential administration remained unclear; however concurrent administration permitted the earliest possible intervention with trastuzumab with possible superiority. There was evidence to support the use of trastuzumab in both lymph node‐positive and high‐risk lymph node‐negative patients, and preliminary data suggested that all patient subgroups that were eligible for the trials benefit equally from trastuzumab. Adjuvant trastuzumab was associated with a risk of cardiotoxicity, the long‐term impact of which remains largely unknown. Routine cardiac risk assessment considering left ventricular ejection fraction, age, and prior history of cardiac events is recommended along with the selection of trastuzumab‐based regimens that minimize cardiotoxicity. Trastuzumab acquisition costs for 1 year of therapy were the largest component of treatment costs. Cancer 2009. © 2009 American Cancer Society.
Computational complexity versus virtual worlds

The ability to simulate complex physical situations in real-time is a critical element of any "virtual world" scenario, as well as being key for many engineering and robotics applications. Unfortunately the computation cost of standard physical simulation methods increases rapidly as the situation becomes more complex. The result is that even when using the fastest supercomputers we are still able to interactively simulate only small, toy worlds. To solve this problem I propose changing the way we represent and simulate physics in order to reduce the computational complexity of physical simulation, thus making possible interactive simulation of complex situations.
Prioritizing Sales Force Decision Areas for Productivity Improvements using a Core Sales Response Function

The time and budgets that managers can devote to enhancing sales force productivity are limited, so sales managers must decide where it is worthwhile to invest in productivity improvements—to improve salespeople’s current effort allocation, realign territories, enhance sales force sizing, or provide more training. To prioritize these alternatives, management must assess the outcomes of investments on the basis of a common metric—profit. This paper proposes to estimate a core sales response function that allows for quantifying the profits derived from each possible action and demonstrates the benefits of this approach through an actual case study.
Cognitive engineering practice: melting theory into reality

Given the growing scope of cognitive engineering, our intent in this paper is to help uncover some of the regularities of the discipline. Adopting a pragmatic view, we attempt to interpret what cognitive engineers really do in practice, and to partly systematize this reality. The paper stresses the need for: (i) an explicit consideration of the demand for intervention and the analyst's preconceptions during the framing of the world-to-study, (ii) the adoption of multiple views for a sufficient understanding of the analysed world, (iii) a continuous reframing of the system under consideration (i.e., topological boundaries as well as timeframes) as the understanding of reality unfolds, (iv) acceptance and exploitation of the dialectic process between analysis/understanding and design/prediction.
Interpretation and Nonformal Environmental Education in Natural Resources Management

Abstract A visitor education strategy was developed, implemented, and tested for its effectiveness in raising levels of knowledge and attitudes toward state nature preserve management. Visitor sociodemographic and site-specific data were also collected and analyzed. A stratified random sample of visitors to four Ohio state nature preserves was taken, and visitor sociodemographic, site-specific, knowledge and attitude data were obtained by a 35-item questionnaire. Results from 1,141 completed questionnaires showed preserve visitors to be mostly male, age 20–39, with incomes ranging from $10,000 to $30,000, and with few of them holding memberships in either community or conservation groups. Most visited state nature preserves frequently, were very satisfied with their most recent preserve visits, and came to the preserves with either family or friends, for solitude and to see sights. A pretest of knowledge of and attitudes toward selected nature preserve management concepts showed that visitors poorly compr.
Car recognition for multiple data sets based on histogram of oriented gradients and support vector machines

In this paper we implement a soft margin support vector machine (SVM) using linear and nonlinear kernels for image classification. The sequential minimal optimization (SMO) method will be used to find the optimal separating hyperplane between the training data that consist of a multidimensional histogram of oriented gradient (HOG) features vectors extracted from multiple data sets.
Differential effects of sumoylation on the activities of CCAAT enhancer binding protein alpha (C/EBPα) p42 versus p30 may contribute in part, to aberrant C/EBPα activity in acute leukemias

In this study, we have examined the role of post-translational modification of the myeloid master regulator C/EBPα by small ubiquitin-related modifier (SUMO). We have used transient transfection analysis, oligonucleotide pulldown assays and chromatin immuno-precititation in all-trans retinoic acid (ATRA)-inducible promyelocytic cell lines MPRO and NB4. We demonstrate that sumoylated wild-type p42-C/EBPα is associated with negative regulation of the myeloid specific lactoferrin (LF) gene in early myeloid cells and that a reduction in p42-C/EBPα sumoylation coincides with expression of the LF gene in maturing myeloid cells. In the acute promyelocytic leukemia cell line NB4 however, sumoylated p42 remains persistently bound to the LF promoter following ATRA-induction. This correlates with lack of lactoferrin expression in these cells. Changes in sumoylation status of C/EBPα thus appear to contribute to a switch that regulates transcriptional activity of this master regulator during normal neutrophil development. We also demonstrate that sumoylation of the AML associated dominant negative p30-C/EBPα isoform does not alter transactivation activity of the LF promoter. This may be because the p30 C/EBPα isoform binds to the LF promoter much less efficiently than its full length counterpart. Our data suggest that the activity of p42-C/EBPα in the developing neutrophil is more sensitive to changes in sumoylation than the p30 isoform. This difference may contribute to the leukemogenic potential of p30-C/EBPα.
Design-time assembly of runtime containment components

In this paper we lay out the design time and space of component assembly in a visual builder, and propose concrete ways of also handling context components seamlessly. We present an environment that allows Java developers to test and evaluate JavaBeans components implementing the extensible runtime containment and services protocol. We enhanced the BeanBox from the Bean Development Kit (BDK) with new visual manipulation capabilities for nested beans, so that it is possible to drag and drop, serialize and de-serialize, group and ungroup, nested beans. By means of these visual manipulations, child beans can be visually put inside context beans.