Miracle-dz/UniFAR-FTUs huggingface dataset:
Strategies to encourage physical activity in patients with hemophilia to improve quality of life

Hemophilia is a bleeding disorder caused by a congenital abnormality of blood coagulation. Until the mid-1970s, patients with hemophilia (PWH) were advised to refrain from physical activity (PA) because of a perceived increased risk of bleeding. Since then, PA, which is recognized as being essential for health maintenance, is now recommended by the World Federation of Hemophilia. Moreover, a number of studies reported that PA can improve treatment efficacy and prevent bleeding in PWH. Physical assessment and intervention in PA are currently used in clinical practice. However, the necessity of PA is not emphasized, and many PWH generally have low- to- no PA. Therefore, a behavior change approach to encourage patient motivation is becoming ever more important. In this article, we review articles addressing PA in PWH and discuss strategies to encourage PA through a behavior change approach by focusing on factors relevant to hemophilia, such as benefits and bleeding risk of PA, risk management of bleeding, PA characteristics, and difficulty with exercise adherence. The trust relationship between clinicians and patients, a transtheoretical model of behavior change, and motivation theory as approaches to promote PA are introduced. Finally, we review a case report of the clinical success of a behavior change approach to promote PA. Many PWH find it difficult to continue PA because of aging, fear of bleeding, insufficient recognition of PA benefits, and psychological problems. Therefore, it is essential and important to perform prophylaxis with PWH and to heighten their understanding of the benefits and risks of PA, before initiating the exercise regimen. For those patients who find it difficult to participate in PA, it is necessary to plan individual-based behavior change approach and encourage self-efficacy.
The relationship between children’s home food environment and dietary patterns in childhood and adolescence

Abstract Objective To identify the correlates of the home food environment (parents’ intake, availability and food-related parenting practices) at the age of 10 years with dietary patterns during childhood and in adolescence. Setting Primary-school children of fifty-nine Flemish elementary schools completed a questionnaire at school in 2002. Four years later they completed a questionnaire by e-mail or mail at home. Their parents completed a questionnaire on food-related parenting practices at baseline. Design Longitudinal study. Subjects The analyses included 609 matched questionnaires. Statistics Multi-level regression analyses were used to identify baseline parenting practices (pressure, reward, negotiation, catering on demand, permissiveness, verbal praise, avoiding negative modelling, availability of healthy/unhealthy food items and mothers’ fruit and vegetable (F&V) and excess scores) associated with children’s dietary patterns (F&V and excess scores). Results Mother’s F&V score was a significant positive independent predictor for children’s F&V score at baseline and follow-up, whereas availability of unhealthy foods was significantly negatively associated with both scores. Negotiation was positively associated with children’s follow-up score of F&V, while permissiveness was positively associated with children’s follow-up excess score. Availability of unhealthy foods and mother’s excess score were positively related to children’s excess score at baseline and follow-up. Conclusions Parental intake and restricting the availability of unhealthy foods not only appeared to have a consistent impact on children’s and adolescents’ diets, but also negotiating and less permissive food-related parenting practices may improve adolescents’ diets.
Expression of Her-2/neu in endometrial carcinoma and its relation with clinicopathological variables

Objective and background: Her-2/neu tyrosine kinase has been implicated in the development and progression of several human cancers and is target for therapeutic intervention. Smaller studies suggest that Her-2/neu may be involved in the tumerogenesis of endometrial adenocarcinoma. The aim of this study was to evaluate Her-2/neu expression in endometrial carcinoma (EC) and its correlation with clinicopathological features in order to define the potential prognostic value of Her-2/neu overexpression in EC. Patients and methods: Nineteen patients with stage I-IV EC were included in this study. Demographic, clinical and pathologic information was obtained and recorded. Her-2/neu expression was evaluated by immunohistochemistry (IHC) on paraffin embedded tissue sections with Her-2/neu antibody. Overexpression was defined as complete membrane staining in greater than 10% of cells. Results: The positive rate of Her-2/neu in EC was 42.1%. Her-2/neu was associated with surgical stage (p 0.05). Conclusion: Our study provides evidence of Her-2/neu overexpression in a considerable proportion of the patients with uterine adenocarcinoma, thus suggesting the opportunity for the possible use of anti-Her-2/neu therapy in this malignancy by selective inhibition of Her-2/neu. The use of Herceptin, a monoclonal antibody directed against Her-2/neu, for therapy of patients harboring Her-2/neu positive EC may be beneficial. Her-2/neu overexpression is related to most of the prognostic variables of EC and may be incorporated into the criteria for determination of tumor aggressiveness as a prognostic marker.
Neural mediators of the intergenerational transmission of family aggression

Abstract Youth exposed to family aggression may become more aggressive themselves, but the mechanisms of intergenerational transmission are understudied. In a longitudinal study, we found that adolescents’ reduced neural activation when rating their parents’ emotions, assessed via magnetic resonance imaging, mediated the association between parents’ past aggression and adolescents’ subsequent aggressive behavior toward parents. A subsample of 21 youth, drawn from the larger study, underwent magnetic resonance imaging scanning proximate to the second of two assessments of the family environment. At Time 1 (when youth were on average 15.51 years old) we measured parents’ aggressive marital and parent–child conflict behaviors, and at Time 2 (≈2 years later), we measured youth aggression directed toward parents. Youth from more aggressive families showed relatively less activation to parent stimuli in brain areas associated with salience and socioemotional processing, including the insula and limbic structures. Activation patterns in these same areas were also associated with youths’ subsequent parent-directed aggression. The association between parents’ aggression and youths’ subsequent parent-directed aggression was statistically mediated by signal change coefficients in the insula, right amygdala, thalamus, and putamen. These signal change coefficients were also positively associated with scores on a mentalizing measure. Hypoarousal of the emotional brain to family stimuli may support the intergenerational transmission of family aggression.
Deep water variability on the southern Agulhas Plateau: Interhemispheric links over the past 170 ka

Sortable silt mean grain sizes together with oxygen and carbon isotopic data produced on the benthic foraminiferal species Fontbotia wuellerstorfi are used to construct high-resolution records of near-bottom flow vigour and deep water ventilation at a core site MD02-2589 located at 2660 m water depth on the southern Agulhas Plateau. The results suggest that during glacial periods (marine oxygen isotope stages 2 and 6, MIS 2 and MIS 6, respectively), there was a persistent contribution of a well-ventilated water mass within the Atlantic to Indian oceanic gateway with a δ 13C signature similar to present-day Northern Component Water (NCW), e.g., North Atlantic Deep Water (NADW). The records of chemical ventilation and near-bottom flow vigor reflect changes in the advection of northern source waters and meridional variability in the location of the Antarctic Circumpolar Current and its associated fronts. We suggest that during Termination II (TII), changes in chemical ventilation are largely decoupled from near-bottom physical flow speeds. A mid-TII climate optimum is associated with a low-flow speed plateau concurrent with a period of increased ventilation shown in the benthic δ 13C of other Southern Ocean records but not in our benthic δ 13C of MD02-2589. The climate optimum is followed by a period of southern cooling around 128 ka coincident with a stronger influence of NCW to interglacial levels at around 124 ka. All proxy records show a near synchronous and rapid shift during the transition from MIS 5a-4 (73 ka). This large event is attributed to a rapid decrease in NADW influence and replacement over the Agulhas Plateau by southern source waters.
Provably secure camouflaging strategy for IC protection

The advancing of reverse engineering techniques has complicated the efforts in intellectual property protection. Proactive methods have been developed recently, among which layout-level IC camouflaging is the leading example. However, existing camouflaging methods are rarely supported by provably secure criteria, which further leads to over-estimation of the security level when countering the latest de-camouflaging attacks, e.g., the SAT-based attack. In this paper, a quantitative security criterion is proposed for de-camouflaging complexity measurements and formally analyzed through the demonstration of the equivalence between the existing de-camouflaging strategy and the active learning scheme. Supported by the new security criterion, two novel camouflaging techniques are proposed, the low-overhead camouflaging cell library and the AND-tree structure, to help achieve exponentially increasing security levels at the cost of linearly increasing performance overhead on the circuit under protection. A provably secure camouflaging framework is then developed by combining these two techniques. Experimental results using the security criterion show that the camouflaged circuits with the proposed framework are of high resilience against the SAT-based attack with negligible performance overhead.
Morphology- and phase-controlled iron oxide nanoparticles stabilized with maleic anhydride grafted polypropylene.

in the fabrication of polymer nano-composites. The advantages of PP-g-MA are that its PPbackbone structure is miscible with polyolefins and its MAfunctional groups are capable of bonding with many organicand inorganic compounds. However, PP-g-MA has rarelybeen reported in the synthesis of magnetic NPs.Herein we report on the synthesis of highly stabilizedFe
Enabling media streaming over LTE-U small cells

In an attempt to face the anticipated spectrum crunch and inspired by the possibility of extending LTE-A to the unlicensed spectrum (LTE-U), in this paper we devise an adaptive channel assignment scheme for video streaming over LTE-U small cells. The proposed scheme adaptively assigns video frames to a subset of monitored channels with the objective of reducing possible starvation instants at user equipments (UEs), and hence maintaining continuous video playback. Specifically, considering coexisting LTE-U small cells and Wi-Fi networks, and leveraging the carrier aggregation (CA) feature in LTE-A, our scheme takes into account the quality of monitored channels, the occupancy of the playback buffers at the UEs, the deadlines and priorities of transmitted video frames, as well as the activity of Wi-Fi users when optimizing the assignment of video frames to channels in the licensed and unlicensed spectrum. According to the numerical results, the proposed scheme returns higher utility, and hence higher probability of correctly receiving video frames, compared to traditional assignment schemes.
Sox2 marks epithelial competence to generate teeth in mammals and reptiles

Tooth renewal is initiated from epithelium associated with existing teeth. The development of new teeth requires dental epithelial cells that have competence for tooth formation, but specific marker genes for these cells have not been identified. Here, we analyzed expression patterns of the transcription factor Sox2 in two different modes of successional tooth formation: tooth replacement and serial addition of primary teeth. We observed specific Sox2 expression in the dental lamina that gives rise to successional teeth in mammals with one round of tooth replacement as well as in reptiles with continuous tooth replacement. Sox2 was also expressed in the dental lamina during serial addition of mammalian molars, and genetic lineage tracing indicated that Sox2+ cells of the first molar give rise to the epithelial cell lineages of the second and third molars. Moreover, conditional deletion of Sox2 resulted in hyperplastic epithelium in the forming posterior molars. Our results indicate that the Sox2+ dental epithelium has competence for successional tooth formation and that Sox2 regulates the progenitor state of dental epithelial cells. The findings imply that the function of Sox2 has been conserved during evolution and that tooth replacement and serial addition of primary teeth represent variations of the same developmental process. The expression patterns of Sox2 support the hypothesis that dormant capacity for continuous tooth renewal exists in mammals.
Title Statistical interactions of multiple oxide traps under BTI stressof nanoscale MOSFETs

We report a thorough 3-D simulation study of the correlation between multiple, trapped charges in the gate oxide of nanoscale bulk MOSFETs under bias and temperature instability (BTI). The role of complex electrostatic interactions between the trapped charges in the presence of random dopant fluctuations is evaluated, and their impact on the distribution of the threshold voltage shift and on the distribution of the number of trapped charges is analyzed. The results justify the assumptions of a Poisson distribution of the BTI-induced trapped charges and of the lack of correlation between them, when accounting for timedependent variability in circuits.
Probability Theory The Neyman – Pearson lemma under g-probability ✩ , ✩ ✩

The Neyman–Pearson fundamental lemma is generalized under g-probability. With convexity assumptions, a sufficient and necessary condition which characterizes the optimal randomized tests is obtained via a maximum principle for stochastic control. To cite this article: S. Ji, X.Y. Zhou, C. R. Acad. Sci. Paris, Ser. I 346 (2008). © 2007 Académie des sciences. Published by Elsevier Masson SAS. All rights reserved. Résumé Lemme de Neyman–Pearson généralisé pour les g-espérances. Le lemme fondamental de Neyman–Pearson est généralisé au cas de g-probabilités. Sous des hypothèses de convexité, une condition suffisante et nécessaire caractérisant le test randomisé optimal est obtenue au moyen du principe du maximum dans le cadre du contrôle stochastique. Pour citer cet article : S. Ji, X.Y. Zhou, C. R. Acad. Sci. Paris, Ser. I 346 (2008). © 2007 Académie des sciences. Published by Elsevier Masson SAS. All rights reserved.
Couples Referred to a Sexual Dysfunction Clinic

Two hundred couples referred to a sexual problems clinic were assessed in a standardised way for their suitability for sex therapy. The assessment focused on the nature of the sexual dysfunction, motivation for treatment, marital and relationship problems, psychiatric status, and physical problems. Approximately one-third of the couples were found to have significant marital and relationship problems, and more than 30% were suffering from psychiatric disorders, although these were usually of mild to moderate intensity. A third of males and 18% of females were suffering from physical disorders likely to contribute to the sexual dysfunction. Patients who were offered sex therapy and who completed their course of treatment were more likely to show high levels of motivation and an absence of physical disorders, marital relationship problems and psychiatric disorder. There should be careful assessment of couples suffering from sexual dysfunction before specific treatment is offered.
Assessing The Public Health Significance Of Subsurface-Contaminant Vapors Intruding Into Indoor Air

To assess the public health significance of exposures via the vapor intrusion pathway for exposure a risk assessment was conducted for a common VOC trichloroethylene (TCE) in an unbiased sample of all the contaminated sites within a large geographic setting (northern New Jersey). Probabilistic methods were used to minimize the impact of single point-estimate input values and to help assess the impact of variability and uncertainty in input parameters. Centraltendency probabilistic methods were used to provide an estimate of the most likely exposure point concentrations. The exposure assessment involved 709 TCE-contaminated groundwater sites with 29,856 groundwater samples from 11,210 monitor wells in the state’s Hazsite database. The groundwater mapping component focused on the 78 sites with one or more TCEcontaminated wells located on land classified as residential. The extent of groundwater contamination beyond the monitor well locations was estimated (mapped) using generic GISbased Inverse Distance Weighted methods on a natural-log scale and additional hypothetical ‘clean wells. ’ The risk assessment focused on the 38 sites with one or more hypothetical residences overlying groundwater with a house-plot averaged concentration greater than 2.7 ug/L. The attenuation of vapors generated from the upper-most groundwater was estimated for the 883 hypothetical overlying residential structures using the USEPA’s national empirical database of vapor attenuation factors. Receptor characteristics based on county-level statistics are used to estimate adult individual and childhood age-specific exposures using probabilistic “age at move in” techniques and with possible in-utero and lactation exposures. The exposure estimates are combined with central-tendency probabilistic estimates of toxicity (primarily based on NYDOH, 2006a) to estimate central-tendency risks for the cancer and non-cancer outcomes under study (Non-Hodgkin’s Lymphoma and Central Nervous System effects). In general the § Corresponding Author: Henry J. Schuver, U.S. EPA – OSW, Ariel Rios Bldg (MC5303W), 1200 Pennsylvania Ave. NW, Washington, DC 20460, Email: 703-308-8656, Fax: 703-308-8609 *This is a personal perspective and does not represent Agency policies or positions. Schuver: The Public Health Significance of Subsurface-Contaminant Vapors Produced by The Berkeley Electronic Press, 2008 Assessing the Public Health Significance of Subsurface-Contaminant Vapors 417 risks are low and highly skewed. Only those few individuals at the highest level of exposure are estimated to be subject to risks of typical concern. However, the methods used include limitations and these results are not likely to be representative of some other areas of the country. Sensitivity and two-dimensional analyses indicate the inputs for vapor attenuation and groundwater concentration dominate the risk estimates.
Effects of sex and parental status on the assessment of infant faces.

To date, research on infant face processing has focused on the appraisal of physical features, but investigations of the effects of sex and parental status on infant emotional expressions have been less prevalent. The present study sought to ﬁll this gap by investigating the effects of sex and parental status on the assessment of infant emotional faces using a community sample of 105 participants (55 female) who were split into 2 groups according to parental status: 53 parents (28 female) comprised those who had a child aged (cid:2) 10 years, and 52 nonparents (27 female) comprised those who did not have children and did not work in a childcare environment. A total of 116 infant faces were presented under 5 emotional conditions (positive, muted positive, neutral, muted negative, and negative). The participants were instructed to rate each facial expression with regard to 3 aspects: pleasure, activation, and intensity. The results revealed a signiﬁcant effect of group, with nonparents perceiving happy and sad infant faces as more intense than parents. We hypothesize that because parents are frequently exposed to intense emotions of their children, their range of intensity may be wider. Therefore, the parents tend to assign a lower intensity to infant emotional faces. In addition, no differences were found between men and women, regardless of parental status, in any of the aspects that were evaluated (pleasure, activation, and intensity) for any emotional expressions (sad, happy, and neutral). This corroborates ﬁndings that mothers and fathers are also often more similar than different in their cognitive responses to children.
Children gesture when speech is slow to come

Human conversation is marked by alternation–partners taking turns speaking and listening. Consequently, language production happens under time pressure; speakers who cannot get their message out quickly enough lose their turn. When adults have struggle to retrieve the words they want to say, they can choose alternatives. But children just beginning to learn language may solve this problem with gesture. If young children’s production systems reﬂect a sensitivity to communicative pressure, they should use deictic gesture to refer when they cannot retrieve a lexical label quickly enough. We conﬁrm this prediction in a longitudinal corpus of naturalistic parent-child interactions, showing that the frequency and recency of a word in children’s input predict the probability that they will refer to its referent with gesture, even for words they know .
Regional mapping of groundwater resources in data-scarce regions: the case of Laos

This study focuses on Laos, a landlocked nation located in South-East Asia with sub-tropical climate and highly seasonal rainfall distribution. Laos is one of the world’s least developed countries, and currently witnesses an unprecedented level of development that is highly reliant on its natural resources, including groundwater. There is currently very limited data and no nationwide assessment of shallow (<30 m) groundwater resources to support sustainable management. This study provides a first step towards addressing this issue by (i) identifying the major aquifer units of the country; (ii) integrating localized data and regional maps into an assessment of the groundwater potential; and (iii) producing quantitative maps of key hydrogeological indicators. Eight aquifer units have been described and evaluated: (i) Basement aquifers, (ii) Volcanic aquifers, (iii) Schists, (iv) Paleozoic sedimentary, (v) Karsts, (vi) Limestones, (vii) Mesozoic sedimentary and (viii) Alluvial sediments. The Mesozoic sandstones and the Alluvial aquifers are the most extensive and productive hydrogeological systems in the country. The Volcanic and Karstic aquifers, although poorly known, might also have important potential. This assessment, along with the maps of quantitative aquifer indicators, provide a significant improvement in both spatial resolution and accuracy compared to previously available information. It will likely support improved management plans and the identification of areas with higher potential for groundwater development.
On the synthesis of the pilot optimal control model

The study continues some work of the authors, this time performing a synthesis of optimal control model of the human pilot in systems with input delay, by removing the Pade or Hess approximations characterizing the pilot structural central nervous block and their introduction as a pure delay block. On the one hand, the method ensures a better accuracy of synthesis and on the other hand is advantageous with respect to general results to date for time delay systems since: a) the optimal control law is given explicitly and b) the Riccati equations for the gain matrices do not contain any time advanced or delayed arguments. The approach is stimulated by recent works of M. Basin and his collaborators.