Miracle-dz/UniFAR-FTUs huggingface dataset:
Insulin-Like Growth Factor Binding Protein-Related Protein 1 Inhibit Retinal Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy.

PURPOSE To explore the inhibitory effect of insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) on retinal angiogenesis and its underlying molecular mechanisms in the mouse model of oxygen-induced retinopathy (OIR). METHODS C57BL/6J mice were classified into three groups as control group, OIR nonintervention group, and OIR intervention group. Postnatal day 12 (P12) mice in OIR intervention group were received recombinant mouse IGFBP-rP1 (50, 100, and 200 ng/mL) intravitreal injection. Five days later, the proliferative neovascular responses were estimated by quantifying the new vessel areas in flattening retinal tissues stained by high molecular fluorescein isothiocyanate-dextran and counting the numbers of neovascular cell nuclei breaking through the internal limiting membrane in cross sections. Expressions of phospho-extracellular signal-regulated kinase 1/2 (p-ERK1/2), ERK1/2, and vascular endothelial growth factor (VEGF) proteins in retinal tissues were assessed by western blot analysis. RESULTS Irregular neovascularization, nonperfusion region, and fluorescence leakage were observed in OIR models. The expression of retinal p-ERK1/2 and VEGF proteins were significantly upregulated in OIR nonintervention group compared with control group. The area ratio of retinal new vessels and the number of neovascular cell nuclei in OIR intervention group both decreased significantly, following the downregulation of retinal p-ERK1/2 protein expression and VEGF protein expression in a dose-dependent manner. Moreover, there was no significant difference in retinal ERK1/2 protein expression. CONCLUSIONS IGFBP-rP1 inhibits retinal angiogenesis by blocking ERK signaling pathway and downregulating VEGF expression in the mouse model of OIR. It highlights the potential importance of IGFBP-rP1 serving as a target of gene therapy for retinal neovascularization in the future.
Effect of Crushed Clay Brick as Coarse Aggregate on Creep Behavior of Concrete

Difference between creep behaviors of concrete made from stone chips and crushed clay bricks, i.e. brick chips as coarse aggregate are examined by means of creep testing on their representative samples. Two different grades of concrete 17.2 and 27.5 N/mm2 are prepared from brick chips and stone chips using appropriate mix design and are tested for creep for up to 50 days. Stone chips and brick chips aggregates used are selected in a way so that their gradation and fineness modulus remains as close as possible. Results from creep testing shows that concrete made from brick chips as coarse aggregate having same strength as that of concrete made from stone chips shows higher creep strain. As concrete strength increases, the difference in creep strain becomes more pronounced. Also, at initial loading condition, concrete made from brick chips shows higher rate of creep strain than that of concrete made from stone chips.
POSH: Proactive co-Operative Self-Healing in Unattended Wireless Sensor Networks

Unattended Wireless Sensor Networks (UWSNs) are composed of many small resource-constrained devices and operate autonomously, gathering data which is periodically collected by a visiting sink. Unattended mode of operation, deployment in hostile environments and value (or criticality) of collected data are some of the factors that complicate UWSN security. This paper makes two contributions. First, it explores a new threat model involving a mobile adversary who periodically compromises and releases sensors aiming to maximize its advantage and overall knowledge of collected data. Second, it constructs a self-healing protocol that allows sensors to continuously and collectively recover from compromise. The proposed protocol is both effective and efficient, as supported by analytical and simulation results.
Mitochondria: Central Organelles for Melatonin′s Antioxidant and Anti-Aging Actions

Melatonin, along with its metabolites, have long been known to significantly reduce the oxidative stress burden of aging cells or cells exposed to toxins. Oxidative damage is a result of free radicals produced in cells, especially in mitochondria. When measured, melatonin, a potent antioxidant, was found to be in higher concentrations in mitochondria than in other organelles or subcellular locations. Recent evidence indicates that mitochondrial membranes possess transporters that aid in the rapid uptake of melatonin by these organelles against a gradient. Moreover, we predicted several years ago that, because of their origin from melatonin-producing bacteria, mitochondria likely also synthesize melatonin. Data accumulated within the last year supports this prediction. A high content of melatonin in mitochondria would be fortuitous, since these organelles produce an abundance of free radicals. Thus, melatonin is optimally positioned to scavenge the radicals and reduce the degree of oxidative damage. In light of the “free radical theory of aging”, including all of its iterations, high melatonin levels in mitochondria would be expected to protect against age-related organismal decline. Also, there are many age-associated diseases that have, as a contributing factor, free radical damage. These multiple diseases may likely be deferred in their onset or progression if mitochondrial levels of melatonin can be maintained into advanced age.
Simplified stability analysis of quasi-brittle notched columns

The stability of columns made of quasi-brittle materials, loaded by an eccentric force at the top and edge notched at their base, is studied. Actually, columns are often made of quasi-brittle materials, as it happens for stone columns of historical monuments. They are frequently cracked or notched at the base, as this region is both more solicited and exposed to impacts that can chip them. Besides, columns are often slender, so that geometrical instability can also occur. Therefore, simplified methods of analyzing the instability due to both column geometry and fracture are useful, as the both can occur contemporarily. A simplified analysis of the instability of notched slender columns is then illustrated, by also avoiding the use of finite elements. This appears to be an advantage, because an easy analysis, although approximated, allows a faster check of the column stability, as well as an intuitive comprehension.
Interpreting Complex Regression Models

Interpretation of a machine learning induced models is critical for feature engineering, debugging, and, arguably, compliance. Yet, best of breed machine learning models tend to be very complex. This paper presents a method for model interpretation which has the main benefit that the simple interpretations it provides are always grounded in actual sets of learning examples. The method is validated on the task of interpreting a complex regression model in the context of both an academic problem -- predicting the year in which a song was recorded and an industrial one -- predicting mail user churn.
Preparation of hollow bioactive glass nanofibers by a facile electrospinning method

Abstract In this communication, hollow bioactive glass (BG) nanofibers were fabricated via a single-nozzle electrospinning method. The morphology of the prepared hollow BG nanofibers was observed by SEM and TEM, and the results showed that BG nanofibers had a continuous hollow interior. The hollow BG nanofibers were incubated in simulated body fluid (SBF) to investigate their apatitemineralization ability, and the result showed that after incubation for 6 h a flower-like apatite was observed on the surface of hollowBGnanofibers, and the Fourier transform infrared (FTIR) result further confirmed the formation of apatite. The results suggested that hollow BG nanofibers could be used for drug delivery and bone regeneration applications due to their unique hollow structure and bioactivity.
Biomarker‐driven phenotyping in Parkinson's disease: A translational missing link in disease‐modifying clinical trials

Past clinical trials of putative neuroprotective therapies have targeted PD as a single pathogenic disease entity. From an Oslerian clinicopathological perspective, the wide complexity of PD converges into Lewy bodies and justifies a reductionist approach to PD: A single‐mechanism therapy can affect most of those sharing the classic pathological hallmark. From a systems‐biology perspective, PD is a group of disorders that, while related by sharing the feature of nigral dopamine‐neuron degeneration, exhibit unique genetic, biological, and molecular abnormalities, which probably respond differentially to a given therapeutic approach, particularly for strategies aimed at neuroprotection. Under this model, only biomarker‐defined, homogenous subtypes of PD are likely to respond optimally to therapies proven to affect the biological processes within each subtype. Therefore, we suggest that precision medicine applied to PD requires a reevaluation of the biomarker‐discovery effort. This effort is currently centered on correlating biological measures to clinical features of PD and on identifying factors that predict whether various prodromal states will convert into the classical movement disorder. We suggest, instead, that subtyping of PD requires the reverse view, where abnormal biological signals (i.e., biomarkers), rather than clinical definitions, are used to define disease phenotypes. Successful development of disease‐modifying strategies will depend on how relevant the specific biological processes addressed by an intervention are to the pathogenetic mechanisms in the subgroup of targeted patients. This precision‐medicine approach will likely yield smaller, but well‐defined, subsets of PD amenable to successful neuroprotection. © 2017 International Parkinson and Movement Disorder Society.
Financial Engineering and Economic Development

The vast literature on financial development focuses mostly on the causal impact of the quantity of financial intermediation on economic development and productivity. This paper, instead, focuses on the role of the financial sector in creating securities that cater to the needs of heterogeneous investors. We describe a dynamic extension of Allen and Gale (1989)? s optimal security design model in which producers can tranche the stochastic cash flows they generate at a cost. Lowering security creation costs in that environment leads to more financial investment, but it has ambiguous effects on capital formation, output, and aggregate productivity. Much of the investment boom caused by increased securitization activities can, in fact, be spent on securitization costs and intermediation rents, with little or even negative effects on development and productivity.
The Edge of Stability: Response Times and Delta Oscillations in Balanced Networks

The standard architecture of neocortex is a network with excitation and inhibition in closely maintained balance. These networks respond fast and with high precision to their inputs and they allow selective amplification of patterned signals. The stability of such networks is known to depend on balancing the strengths of positive and negative feedback. We here show that a second condition is required for stability which depends on the relative strengths and time courses of fast (AMPA) and slow (NMDA) currents in the excitatory projections. This condition also determines the response time of the network. We show that networks which respond quickly to an input are necessarily close to an oscillatory instability which resonates in the delta range. This instability explains the existence of neocortical delta oscillations and the emergence of absence epilepsy. Although cortical delta oscillations are a network-level phenomenon, we show that in non-pathological networks, individual neurons receive sufficient information to keep the network in the fast-response regime without sliding into the instability.
Interaction of high temperature and Salmonella pullorum antigen concentration on serum agglutinin and corticosteroid responses in white rock chickens.

In three experiments, 6- to 7-week-old chickens were exposed to one or two standard heating episodes and were injected immediately afterward with different concentrations of heat-killed Salmonella pullorum antigen (Ag) or phosphate-buffered saline. The standard heat episode consisted of three . 5-hr exposures of 44 to 46 C with . 5-hr periods of 22 C between exposures. Nonheated chickens were maintained at 22 C. When two heating episodes were used, there was a 12-hr interval between episodes. Sera from blood collected at 0 through 15 days postimmunization (PI) were titrated for total agglutinins and assayed for corticosteroids in all three experiments. Additionally, in Experiment 3, sera were titrated for 2-mercaptoethanol-resistant (2-MER) antibody. Total agglutinins were suppressed from 5 through 13 days PI by one heating episode in birds receiving lower doses of Ag but not in those receiving higher doses. When birds were exposed to two heat episodes, 12 hr apart, total agglutinin titers were suppressed in birds receiving the low Ag dose during the induction phase (4 to 5 days PI) only. During the declining phase (7 to 14 days PI), the effect was reversed, and titers were significantly lower in heated birds receiving the higher dosage. These results are similar to those previously obtained with ACTH (adrenocorticotropin). Determination of 2-MER antibody indicated that IgM was probably suppressed during the induction of the immune response but that IgG was suppressed during the declining phase of the response. Serum corticosteroid concentrations were significantly increased immediately after exposure to high temperature. (ABSTRACT TRUNCATED AT 250 WORDS)
Compensatory Saccades Are Associated With Physical Performance in Older Adults: Data From the Baltimore Longitudinal Study of Aging.

OBJECTIVE To determine whether compensatory saccade metrics observed in the video head impulse test, specifically saccade amplitude and latency, predict physical performance. STUDY DESIGN Cross-sectional analysis of the Baltimore Longitudinal Study of Aging, a prospective cohort study. SETTING National Institute on Aging Intramural Research Program Clinical Research Unit in Baltimore, Maryland. PATIENTS Community-dwelling older adults. INTERVENTION(S) Video head impulse testing was performed, and compensatory saccades and horizontal vestibulo-ocular reflex (VOR) gain were measured. Physical performance was assessed using the Short Physical Performance Battery (SPPB), which included the feet side-by-side, semitandem, tandem, and single-leg stance; repeated chair stands; and usual gait speed measurements. MAIN OUTCOME MEASURE(S) Compensatory saccade amplitude and latency, VOR gain, and SPPB performance. RESULTS In 183 participants who underwent vestibular and SPPB testing (mean age 71.8 yr; 53% females), both higher mean saccade amplitude (odds ratio [OR] =1.62, p = 0.010) and shorter mean saccade latency (OR = 0.88, p = 0.004) were associated with a higher odds of failing the tandem stand task. In contrast, VOR gain was not associated with any physical performance measure. CONCLUSION We observed in a cohort of healthy older adults that compensatory saccade amplitude and latency were associated with tandem stance performance. Compensatory saccade metrics may provide insights into capturing the impact of vestibular loss on physical function in older adults.
Computational fluid dynamics of cerebral aneurysm coiling using high-resolution and high-energy synchrotron X-ray microtomography: comparison with the homogeneous porous medium approach

Background Computational modeling of intracranial aneurysms provides insights into the influence of hemodynamics on aneurysm growth, rupture, and treatment outcome. Standard modeling of coiled aneurysms simplifies the complex geometry of the coil mass into a homogeneous porous medium that fills the aneurysmal sac. We compare hemodynamics of coiled aneurysms modeled from high-resolution imaging with those from the same aneurysms modeled following the standard technique, in an effort to characterize sources of error from the simplified model. Materials Physical models of two unruptured aneurysms were created using three-dimensional printing. The models were treated with coil embolization using the same coils as those used in actual patient treatment and then scanned by synchrotron X-ray microtomography to obtain high-resolution imaging of the coil mass. Computational modeling of each aneurysm was performed using patient-specific boundary conditions. The coils were modeled using the simplified porous medium or by incorporating the X-ray imaged coil surface, and the differences in hemodynamic variables were assessed. Results X-ray microtomographic imaging of coils and incorporation into computational models were successful for both aneurysms. Porous medium calculations of coiled aneurysm hemodynamics overestimated intra-aneurysmal flow, underestimated oscillatory shear index and viscous dissipation, and over- or underpredicted wall shear stress (WSS) and WSS gradient compared with X-ray-based coiled computational fluid dynamics models. Conclusions Computational modeling of coiled intracranial aneurysms using the porous medium approach may inaccurately estimate key hemodynamic variables compared with models incorporating high-resolution synchrotron X-ray microtomographic imaging of complex aneurysm coil geometry.
Alkali-Activated Fly ash-slag Cement based nuclear waste forms

This paper is based on the results of an in-progress research project on Alkali-Activated Cement System at MRL. The objective of this research is to establish the potential for large volume use of fly ash and slag as main components of the cement system. Alkali-activated Fly ash-slag Cement (AFC) was studied as a matrix for immobilization of nuclear waste. AFC is characterized by high early strength, high ultimate strength, low porosity, lower solubilities of the hydrates, and high resistance to chemical corrosion as well as to freezing and thawing. All these advanced properties are particularly favorable to the immobilization the nuclear wastes.
Rare copy number variants in patients with congenital conotruncal heart defects.

BACKGROUND Previous studies using different cardiac phenotypes, technologies and designs suggest a burden of large, rare or de novo copy number variants (CNVs) in subjects with congenital heart defects. We sought to identify disease-related CNVs, candidate genes, and functional pathways in a large number of cases with conotruncal and related defects that carried no known genetic syndrome. METHODS Cases and control samples were divided into two cohorts and genotyped to assess each subject's CNV content. Analyses were performed to ascertain differences in overall CNV prevalence and to identify enrichment of specific genes and functional pathways in conotruncal cases relative to healthy controls. RESULTS Only findings present in both cohorts are presented. From 973 total conotruncal cases, a burden of rare CNVs was detected in both cohorts. Candidate genes from rare CNVs found in both cohorts were identified based on their association with cardiac development or disease, and/or their reported disruption in published studies. Functional and pathway analyses revealed significant enrichment of terms involved in either heart or early embryonic development. CONCLUSION Our study tested one of the largest cohorts specifically with cardiac conotruncal and related defects. These results confirm and extend previous findings that CNVs contribute to disease risk for congenital heart defects in general and conotruncal defects in particular. As disease heterogeneity renders identification of single recurrent genes or loci difficult, functional pathway and gene regulation network analyses appear to be more informative. Birth Defects Research 109:271-295, 2017. © 2017 Wiley Periodicals, Inc.
Individual-Based Compulsive Sexual Behavior Scale: Its Development and Importance in Examining Compulsive Sexual Behavior

ABSTRACT Compulsive sexual behavior comprises individual-based (e.g., sexual fantasies, compulsive sexual thoughts, masturbation) and partnered (e.g., interpersonal sexual conquests, repeated infidelity) facets. Most instruments for assessing compulsive sexual behavior, however, focus less on the individual-based facet and specifically on fantasies and compulsive thoughts. In the current research, we developed and validated an individual-based compulsive sexual behavior scale (I-CSB). In Study 1 (N = 492), the factorial structure of the I-CSB was examined. In Study 2 (N = 406), we assessed I-CSB's convergent validity. In Study 3 (N = 112), we examined whether the I-CSB differentiates between individuals who suffer from compulsive sexual behavior and those who do not. Results revealed a four-factor structure for individual-based compulsive sexual behavior that is associated with an intense inner conflict regarding sexuality (high arousal contrasting with high sexual anxiety), and that accounts for approximately 75% of the differences between people with compulsive sexual behavior and controls. Results are discussed in light of the need for a broader understanding of compulsive sexual behavior.
Docear: an academic literature suite for searching, organizing and creating academic literature

In this demonstration-paper we introduce Docear, an 'academic literature suite'. Docear offers to scientists what an office suite like Microsoft Office offers to office workers. While an office suite bundles various applications for office workers (word processing, spreadsheets, presentation software, etc.), Docear bundles several applications for scientists: academic search engine, PDF reader, reference manager, word processor, mind mapping module, and recommender system. Besides Docear's general concept, its special features are presented in this paper, namely a modular composition, free full-text access to literature, information management as mind map, automatic metadata extraction of PDFs and recommendations.
STAT5BN642H is a driver mutation for T cell neoplasia

STAT5B is often mutated in hematopoietic malignancies. The most frequent STAT5B mutation, Asp642His (N642H), has been found in over 90 leukemia and lymphoma patients. Here, we used the Vav1 promoter to generate transgenic mouse models that expressed either human STAT5B or STAT5BN642H in the hematopoietic compartment. While STAT5B-expressing mice lacked a hematopoietic phenotype, the STAT5BN642H-expressing mice rapidly developed T cell neoplasms. Neoplasia manifested as transplantable CD8+ lymphoma or leukemia, indicating that the STAT5BN642H mutation drives cancer development. Persistent and enhanced levels of STAT5BN642H tyrosine phosphorylation in transformed CD8+ T cells led to profound changes in gene expression that were accompanied by alterations in DNA methylation at potential histone methyltransferase EZH2-binding sites. Aurora kinase genes were enriched in STAT5BN642H-expressing CD8+ T cells, which were exquisitely sensitive to JAK and Aurora kinase inhibitors. Together, our data suggest that JAK and Aurora kinase inhibitors should be further explored as potential therapeutics for lymphoma and leukemia patients with the STAT5BN642H mutation who respond poorly to conventional chemotherapy.
Silicon Nanowires Based Resistors for Bacteria Detection

Silicon nanowires (SiNWs) based resistors used as bacteria sensors are fabricated using the classical silicon technologies. SiNWs are grown by vapor liquid solid (VLS) method using gold as catalyst. Electrodes of the device are made of heavily in-situ doped polycristalline silicon. Results show potential use of the corresponding resistors, with SiNWs as sensitive units, for bacteria detection. Bacteria are preferentially hanged into SiNWs array and electrical resistance of the device decreases due to the presence of bacteria. Such resistors are promising bacteria sensors to monitor contamination in controlled environment for hygiene, fabricated in a simple and low-cost fabrication technology.