Miracle-dz/UniFAR-FTUs huggingface dataset:
Population trends in mitral valve surgery in Finland between 1997 and 2014: the finnish CVD register

Abstract Objectives. Contemporary, nationwide data on trends in mitral valve surgery are scarce. Our aim was to investigate changes in procedure rates, patient selection, and post-procedural prognosis of open-heart mitral valve surgery in Finland. Design. We combined data from three nationwide administrative registers with compulsory reporting. We identified patients who had undergone first-ever open-heart mitral valve surgery between 1997 and 2014 and followed them for adverse events. We examined trends in mitral valve surgery over three six-year time periods (1997-2002, 2003-2008, and 2009-2014). Results. 3684 mitral valve procedures (mean age: 67.0 ± 10.9 years, 42.6% women) were performed in 1997–2014 in Finland. During this period, mitral valve repair operations became more common than replacements and we observed an increasing trend in the use of bioprosthetic valves. Between 1997-2002 and 2009-2014, the mean age of patients undergoing mitral valve surgery and the proportion of urgent surgeries increased (p < .001 for both). The proportion of women undergoing surgery decreased while the share of patients with hypertension (p = .023) or diabetes (p = .026) increased. The multivariable-adjusted risk of 28-day (hazard ratio, 0.55; 95% confidence interval, 0.37–0.83) and 6-year (hazard ratio, 0.80; 95% confidence interval, 0.67–0.97) post-operative mortality was lower in the last six-year period than in 1994-1998. Conclusions. Short- and long-term mortality of mitral valve surgery patients in Finland has decreased from 1997 to 2014 despite the patients being older and having more comorbidities. Understanding the changing characteristics and prognosis of these patients is important for the interpretation of previous and future cohort studies and trials.
Design and Construction of the Full-Length Prototype of the 11-T Dipole Magnet for the High Luminosity LHC Project at CERN

The luminosity upgrade of the Large Hadron Collider (LHC) at CERN requires the installation of additional collimators in the dispersion suppressor regions of the accelerator. The upgrade foresees the installation of one additional collimator on either side of interaction point 7 (IP7) at the location of the existing main dipoles (MBs) that will be replaced by shorter and more powerful dipoles, and of one additional collimator on either side of IP2 at the location of existing empty cryostats. This paper describes the design and the construction status of the full-length prototype of the 11-T dipole magnet, which is needed for IP7. This magnet features a two-in-one structure, like the LHC MB, impregnated coils made of Nb3Sn conductor, an inner bore of 60 mm, and a magnetic length of about 5.3 m. Two 11-T magnets are needed to replace a 15-m long MB. A by-pass cryostat placed in between the two magnets allows creating a room temperature space for the additional collimators. The magnet is designed to provide the same integrated field as the MB at nominal field. However, due to the difference in transfer function at lower field, a correction by means of a trim current has been considered. A full-length prototype is currently under construction at CERN with the goal of developing the manufacturing and inspection procedures prior to launch the series production. For this, new tooling has been developed and optimized during the fabrication of fully representative practice coils. This paper describes the design of the magnet, the main manufacturing steps, and corresponding quality indicators, which will be used to monitor the series production. Finally, the production and installation schedule will be presented.
Effect of Temperature on the Quasi-static Strength and Fatigue Resistance of Bonded Composite Double Lap Joints

Abstract Fibre reinforced polymer composites (FRP's) are often used to reduce the weight of a structure. Traditionally the composite parts are bolted together; however, increased weight savings can often be achieved by adhesive bonding or co-curing the parts. The reason that these methods are often not used for structural applications is due to the lack of trusted design methods and concerns about long-term performance. The authors have attempted to address these issues by studying the effects of fatigue loading, test environment and pre-conditioning on bonded composite joints. Previous work centered on the lap-strap joint which was representative of the long-overlap joints common in aerospace structures. However, it was recognised that in some applications short-overlap joints will be used and these joints might behave quite differently. In this work, double-lap joints were tested both quasi-statically and in fatigue across the temperature range experienced by a jet aircraft. Two variants on the double-lap joint sample were used for the testing, one with multidirectional (MD) CFRP adherends and the other with unidirectional (UD) CFRP adherends. Finite element analysis was used to analyse stresses in the joints. It was seen that as temperature increased both the quasi-static strength and fatigue resistance decreased. The MD joints were stronger at low temperatures and the UD joints stronger at high temperatures. It was proposed that this was because at low temperature the strength was determined by the peak stresses in the joints, whereas, at high temperatures, strength is controlled by creep of the joints which is determined by the minimum stresses in the joint. This argument was supported by the stress analysis.
A New Inductive Power Transfer Topology Using Direct AC–AC Converter With Active Source Current Waveshaping

Generally, in wireless inductive power transfer (IPT) system, the power is processed through multiple power transfer stages and this leads to lower efficiency and higher cost of the system. Recent research shows that the use of a direct ac–ac converter in an IPT system compensates these limitations significantly. However, one of the major challenges of the IPT circuit with direct ac–ac converter is to achieve multiple control goals through a single converter. These include load power requirement, maintaining high-quality source current and achieving soft switching of inverter switches, etc. In the existing literatures, the research is more focused on meeting load power requirement and soft switching of inverter switches. The major focus of this paper is to propose, analyze, and control a new IPT power converter topology using current-fed direct ac–ac converter. Compare with existing buck derived, i.e., voltage source ac–ac converter topologies, the proposed topology is boost derived; therefore, active source current waveshaping is easily obtained. The complete control is carried out through two loops, where the outer output current loop ensures load requirements and inner loop maintains the high-quality grid current. The detail of steady-state and dynamic analysis and design procedure of the converter is presented. Experimental results obtained from a 1.2-kW lab-build prototype are included to verify the analysis and proposed control.
The Efficiency of Multi-Unit Electricity Auctions Author ( s ) :

JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact support@jstor.org. International Association for Energy Economics is collaborating with JSTOR to digitize, preserve and extend access to The Energy Journal. Using a complete information game-theoretic model, we analyze the performance of different electricity auction structures in attaining efficiency (i. e. , least-cost dispatch). We find that an auction structure where generators are allowed to bid for load "slices" outperforms an auction structure where generators submit bids for different hours in the day.
Procedures for Dealing with Optimism Bias in Transport Planning

The Supplementary Green Book Guidance on Optimism Bias (HM Treasury 2003) with reference to the Review of Large Public Procurement in the UK (Mott MacDonald 2002) notes that there is a demonstrated, systematic, tendency for project appraisers to be overly optimistic and that to redress this tendency appraisers should make explicit, empirically based adjustments to the estimates of a project’s costs, benefits, and duration. HM Treasury recommends that these adjustments be based on data from past projects or similar projects elsewhere, and adjusted for the unique characteristics of the project in hand. In the absence of a more specific evidence base, HM Treasury has encouraged departments to collect data to inform future estimates of optimism, and in the meantime use the best available data. In response to this, the Department for Transport (henceforth DfT), has contracted Bent Flyvbjerg in association with COWI to undertake the consultancy assignment "Procedures for dealing with Optimism Bias in Transport Planning". The present Guidance Document is the result of this assignment.
An adaptive method for edge preserving denoising

Interpretation of image capacity is such of the objectives in computer eyes decidedly in image processing. In this era it has accustomed about acquaintance of researchers. In image estimation the allotment of the image into article and accomplishments is a acute step. Analysis separates an image into its basal regions or objects. Image analysis t needs to articulation the article from the accomplishments to present the image absolutely and ascertain the agreeable of the image carefully. In this framework, bend apprehension is a basal apparatus for image segmentation. In this cardboard an try is fabricated to abstraction the achievement of a lot of consistently acclimated bend apprehension techniques for image analysis and added the allegory of these techniques is apprenticed out mutually an agreement by application MATLAB software.
Dynamic Comparator with Using Negative Resistance and CMOS Input Pair Strategies in FS =4MHz-10GHz

A 4MHz-10GHz, 10ps/dec dynamic comparator with using negative resistance and CMOS input differential pair is proposed and designed in IBM 130nm CMOS process technology. In this design, we effort that taking maximum sampling frequency from CMOS technology and the proposed comparator consumes 110nw-146µW at 1.5V supply
Carbon Nanotube–Polymer Composites: Device Properties and Photovoltaic Applications

This chapter provides an in-depth coverage of recent advances in the areas of the development and characterization of electro-optically active, device-grade carbon nanotube (CNT)–polymer blends. These new organic–inorganic multifunctional nanocomposites share many advanced characteristics which make them ideally suited for industrial scale, high-throughput manufacturing of lightweight, flexible electronic, light switching and emitting as well as energy harvesting devices of extremely low cost. The fundamental aspects and the physical mechanisms controlling light–matter interaction, photo-conversion, and photo-generated charge-carrier transport in these nanotube–polymer composites as well as the influence of the processing conditions on the electronic properties and device-related performances are further reviewed and discussed.
Application of wet milling techniques to produce micronized and nanonized drug pre-dispersions for the development of intranasal formulations

This article reports on the microand nanonization of meloxicam (MEL) with the aim of developing predispersions as intermediates for the design of intranasal formulations. As a new approach, combined wet milling technology was developed in order to reduce the particle size of the MEL. Different milling times resulted in microor nanosized MEL in the pre-dispersions with polyvinyl alcohol as stabilizer agent, which were directly used for preparing intranasal liquid formulations with the addition of sodium hyaluronate as mucoadhesive agent. Reduction of the MEL particle size into the nano range led to increased saturation solubility and dissolution velocities, and increased adhesiveness to surfaces as compared with microsized MEL particles. A linear correlation was demonstrated between the specific surface area of MEL and the AUC. The in vitro and in vivo studies indicated that the longer residence time and the uniform distribution of nano MEL spray throughout an artificial membrane and the nasal mucosa resulted in better diffusion and a higher AUC. Nanosized MEL may be suggested for the development of an innovative dosage form with a different dose of the drug, as a possible administration route for pain management. ã 2015 Elsevier B.V. All rights reserved.
Micro aerial vehicle autonomous flight control in tunnel environment

In order to solve the problem of unmanned aerial vehicle (UAV) tunnel autonomous flight in GPS-Denied environment, this paper designs the ultrasonic environment perception system and introduces the algorithm of three-dimensional (3D) wall-following navigation. Firstly, the framework of aerial vehicle system and the ultrasonic environment perception system are presented. Then three-dimensional (3D) wall-following navigation algorithm is combined with PID algorithm according to the dynamic model of aerial vehicle. Finally, extensive experiments are carried out in the tunnel where the optimal control parameters are obtained. The experimental results indicate that the UAV can fly in the center of tunnel smoothly and realize autonomous flight steadily in a confined space.
In Situ Observation of the Electrochemical Lithiation of a Single SnO2 Nanowire Electrode

Fragile Tin Oxide Electrodes While tin oxide has a high energy density, and would thus make an attractive anode material for a Li-ion battery, it undergoes significant volume changes when Li is intercalated. The large strains cause cracking, pulverization, and a resultant loss of electrical conduction. Huang et al. (p. 1515; see the Perspective by Chiang) used in situ transmission electron microscopy on a single tin oxide nanowire to identify the physical changes that occur during intercalation and observed a moving cloud of dislocations that separated the reacted and unreacted sections. Upon completion of the electrochemical charging, the nanowire showed up to 90% elongation and a 35% increase in diameter. Transmission electron microscopy reveals dimensional changes in a tin oxide nanowire as it intercalates lithium. We report the creation of a nanoscale electrochemical device inside a transmission electron microscope—consisting of a single tin dioxide (SnO2) nanowire anode, an ionic liquid electrolyte, and a bulk lithium cobalt dioxide (LiCoO2) cathode—and the in situ observation of the lithiation of the SnO2 nanowire during electrochemical charging. Upon charging, a reaction front propagated progressively along the nanowire, causing the nanowire to swell, elongate, and spiral. The reaction front is a “Medusa zone” containing a high density of mobile dislocations, which are continuously nucleated and absorbed at the moving front. This dislocation cloud indicates large in-plane misfit stresses and is a structural precursor to electrochemically driven solid-state amorphization. Because lithiation-induced volume expansion, plasticity, and pulverization of electrode materials are the major mechanical effects that plague the performance and lifetime of high-capacity anodes in lithium-ion batteries, our observations provide important mechanistic insight for the design of advanced batteries.
Tree species diversity alters plant defense investment in an experimental forest plantation in southern Mexico

How plant species diversity affects traits conferring herbivore resistance (e.g., chemical defenses), as well as the mechanisms underlying such effects, has received little attention. One potential mechanism for the effect of diversity on plant defenses is that increased plant growth at high diversity could lead to reduced investment in defenses via growth–defense trade‐offs. We measured tree growth (diameter at breast height) and collected leaves to quantify total phenolics in 2.5‐year‐old plants of six tropical tree species (N = 597 plants) in a young experimental plantation in southern Mexico. Selected plants were classified as monocultures or as polycultures represented by mixtures of four of the six species examined. Tree species diversity had a significant negative effect on total phenolics, where polycultures exhibited a 13 percent lower mean concentration than monocultures. However, there was marked variation in the effects of diversity on defenses among tree species, with some species exhibiting strong reductions in phenolic levels in mixtures, whereas others were unresponsive. In addition, tree species diversity had no effect on growth, nor was the negative effect of diversity on chemical defenses mediated by a growth–defense trade‐off. These results demonstrate that tree diversity can alter investment in chemical defenses in long‐lived tree species but that such effect may not always be under strong control by plant endogenous resource allocation trade‐offs. Regardless of the underlying mechanism, these findings have important implications for predicting effects on consumers and ecosystem function.
The Effects of 6 Months of Progressive High Effort Resistance Training Methods upon Strength, Body Composition, Function, and Wellbeing of Elderly Adults

Purpose The present study examined the progressive implementation of a high effort resistance training (RT) approach in older adults over 6 months and through a 6-month follow-up on strength, body composition, function, and wellbeing of older adults. Methods Twenty-three older adults (aged 61 to 80 years) completed a 6-month supervised RT intervention applying progressive introduction of higher effort set end points. After completion of the intervention participants could choose to continue performing RT unsupervised until 6-month follow-up. Results Strength, body composition, function, and wellbeing all significantly improved over the intervention. Over the follow-up, body composition changes reverted to baseline values, strength was reduced though it remained significantly higher than baseline, and wellbeing outcomes were mostly maintained. Comparisons over the follow-up between those who did and those who did not continue with RT revealed no significant differences for changes in any outcome measure. Conclusions Supervised RT employing progressive application of high effort set end points is well tolerated and effective in improving strength, body composition, function, and wellbeing in older adults. However, whether participants continued, or did not, with RT unsupervised at follow-up had no effect on outcomes perhaps due to reduced effort employed during unsupervised RT.
Sensitivity and Specificity of an Executive Function Screener at Identifying Children With ADHD and Reading Disability

Objective: This study evaluated the sensitivity/specificity of a global sum score (GSS) from the Behavior Assessment System for Children, Second Edition, Executive Function screener (BASC-2-EF) at classifying children with/without ADHD and/or reading disability (RD). Method: The BASC-2 Teacher/Parent Rating Scales (TRS/PRS) were completed for children (8-12 years old; 43.1% female) with no diagnosis (n = 53), RD (n = 34), ADHD (n = 85), co-morbid RD/ADHD (n = 36), and other diagnoses (n = 15). Receiver operating characteristic (ROC) curve analyses evaluated the sensitivity/specificity of the BASC-2-EF GSS at discriminating between children with/without ADHD or RD. Results: Area under the curve (AUC) scores indicated the sensitivity/specificity of the BASC-2-EF GSS at discriminating between children with/without ADHD (TRS: AUC = .831, p < .001; PRS: AUC = .919, p < .001), with/without RD (TRS: AUC = .724, p = .001; PRS: AUC = .615, p = .101), and with ADHD or RD through post hoc analysis (TRS: AUC = .674, p = .006; PRS: AUC = .819, p < .001). Conclusion: The findings support utilizing the BASC-2-EF GSS when differentiating ADHD from RD and typical development.
Preparation of submicron particles for theranostic applications : imaging and therapy

The objective of this study was to prepare and characterize multifunctional submicron particles that can be used for diagnosis and therapy of several fatal diseases including cancer (i.e theranostic). For this purpose, a systematic study was performed in order to optimize the process parameters for preparation of polymeric particle that can be used as a platform for effective delivery of drugs and imaging labels. The imaging agent (FluoSpheres®) was encapsulated via double emulsion solvent evaporation technique to be used fluorescent contrast agent and their in vitro evaluation was performed. Then, gold nanoparticles were prepared by using NaBH4 reduction method, characterized and encapsulated by polycaprolactone polymer for in vitro applications. Finally, the gold nanoparticle were loaded into polycaprolactone particle along with a hydrophilic drug (Nefopam) and a hydrophobic drug (benzyl benzoate) simultaneously. The prepared particles were then characterized physicochemically and in vitro skin penetration study was performed
Climate change affects colonization dynamics in a metacommunity of three Daphnia species

Climate change is expected to alter the range and abundance of many species by influencing habitat qualities. For species living in fragmented populations, not only the quality of the present patches but also access to new habitat patches may be affected. Here, we show that colonization in a metacommunity can be directly influenced by weather changes, and that these observed weather changes are consistent with global climate change models. Using a long‐term dataset from a rock pool metacommunity of the three species Daphnia magna, Daphnia longispina and Daphnia pulex with 507 monitored habitat patches, we correlated a four‐fold increase in colonization rate with warmer, drier weather for the period from 1982 to 2006. The higher colonization rate after warm and dry summers led to an increase in metacommunity dynamics over time. A mechanistic explanation for the increased colonization rate is that the resting stages have a higher exposure to animal and wind dispersal in desiccated rock pools. Although colonization rates reacted in the same direction in all three species, there were significant species‐specific effects that resulted in an overall change in the metacommunity composition. Increased local instability and colonization dynamics may even lead to higher global stability of the metacommunity. Thus, whereas climate change has been reported to cause a unidirectional change in species range for many other species, it changes the dynamics and composition of an entire community in this metacommunity, with winners and losers difficult to predict.
A common developmental program can produce diverse leaf shapes

Summary Eudicot leaves have astoundingly diverse shapes. The central problem addressed in this paper is the developmental origin of this diversity. To investigate this problem, we propose a computational model of leaf development that generalizes the largely conserved molecular program for the reference plants Arabidopsis thaliana, Cardamine hirsuta and Solanum lycopersicum. The model characterizes leaf development as a product of three interwoven processes: the patterning of serrations, lobes and/or leaflets on the leaf margin; the patterning of the vascular system; and the growth of the leaf blade spanning the main veins. The veins play a significant morphogenetic role as a local determinant of growth directions. We show that small variations of this model can produce diverse leaf shapes, from simple to lobed to compound. It is thus plausible that diverse shapes of eudicot leaves result from small variations of a common developmental program.