Miracle-dz/UniFAR-FTUs huggingface dataset:
Answering FO+MOD Queries under Updates on Bounded Degree Databases

We investigate the query evaluation problem for fixed queries over fully dynamic databases, where tuples can be inserted or deleted. The task is to design a dynamic algorithm that immediately reports the new result of a fixed query after every database update. We consider queries in first-order logic (FO) and its extension with modulo-counting quantifiers (FO+MOD) and show that they can be efficiently evaluated under updates, provided that the dynamic database does not exceed a certain degree bound. In particular, we construct a data structure that allows us to answer a Boolean FO+MOD query and to compute the size of the result of a non-Boolean query within constant time after every database update. Furthermore, after every database update, we can update the data structure in constant time such that afterwards we are able to test within constant time for a given tuple whether or not it belongs to the query result, to enumerate all tuples in the new query result, and to enumerate the difference between the old and the new query result with constant delay between the output tuples. The preprocessing time needed to build the data structure is linear in the size of the database. Our results extend earlier work on the evaluation of first-order queries on static databases of bounded degree and rely on an effective Hanf normal form for FO+MOD recently obtained by Heimberg, Kuske, and Schweikardt (LICS 2016).
Astigmatic Axis is Related to the Level of Spherical Ametropia

Purpose. Against-the-rule (ATR) astigmatism has been shown to be a risk factor for subsequent myopia development. In this study, we evaluated the relationship between astigmatic axis and the level of spherical ametropia in both myopes and hypermetropes. Methods. Astigmatic axes were analyzed in two distinct cohorts. First, 53 high myopes from families that were recruited for linkage analysis were compared with an age-matched control group derived from family members. Second, cross-sectional data were analyzed for 90,884 subjects attending 19 optometric practices in the north of England. Initially, the relationship between astigmatic axis and cylinder power and between axis and sphere power were analyzed in 21- to 40-year olds and 21- to 30-year olds, respectively, to control for the effects of age. Multivariate logistic regression analysis was then performed using data for all compound astigmats in the cohort to examine the effect of sphere power, cylinder power, age, and sex on the odds of subjects having either ATR or with-the-rule (WTR) astigmatism. Results. In the genetic study cohort, there was an excess of WTR astigmats in the high myopes compared with controls, but this only reached significance for the right eye. In the much larger optometric practice sample, the association of WTR astigmatism with high myopia was highly significant. A parallel increase in WTR astigmatism was also found for high hypermetropes. In addition, the odds of having WTR astigmatism were increased if subjects were young or had a high cylinder power. ATR astigmatism occurred more often with increasing age and in subjects with lower spherical ametropia. Indeed, for 21- to 30-year-old subjects with low myopia (≥−2.00 DS in the least minus meridian), ATR occurred more often than WTR astigmatism. Conclusion. Astigmatic axis was found to be related to the level of ametropia, with both a higher spherical component or higher cylinder power increasing the odds of astigmatism being WTR. Low ametropes, particularly myopes, were more likely to have axes ATR.
PerR Controls Oxidative Stress Resistance and Iron Storage Proteins and Is Required for Virulence in Staphylococcus aureus

ABSTRACT The Staphylococcus aureus genome encodes three ferric uptake regulator (Fur) homologues: Fur, PerR, and Zur. To determine the exact role of PerR, we inactivated the gene by allelic replacement using a kanamycin cassette, creating strain MJH001 (perR). PerR was found to control transcription of the genes encoding the oxidative stress resistance proteins catalase (KatA), alkyl hydroperoxide reductase (AhpCF), bacterioferritin comigratory protein (Bcp), and thioredoxin reductase (TrxB). Furthermore, PerR regulates transcription of the genes encoding the iron storage proteins ferritin (Ftn) and the ferritin-like Dps homologue, MrgA. Transcription of perR was autoregulated, and PerR repressed transcription of the iron homeostasis regulator Fur, which is a positive regulator of catalase expression. PerR functions as a manganese-dependent, transcriptional repressor of the identified regulon. Elevated iron concentrations produced induction of the PerR regulon. PerR may act as a peroxide sensor, since addition of external hydrogen peroxide to 8325-4 (wild type) resulted in increased transcription of most of the PerR regulon, except forfur and perR itself. The PerR-regulatedkatA gene encodes the sole catalase of S. aureus, which is an important starvation survival determinant but is surprisingly not required for pathogenicity in a murine skin abscess model of infection. In contrast, PerR is not necessary for starvation survival but is required for full virulence (P < 0.005) in this model of infection. PerR ofS. aureus may act as a redox sentinel protein during infection, analogous to the in vitro activities of OxyR and PerR ofEscherichia coli and Bacillus subtilis, respectively. However, it differs in its response to the metal balance within the cell and has the added capability of regulating iron uptake and storage.
In vitro evaluation of surface functionalized gelatin nanoparticles for macrophage targeting in the therapy of visceral leishmaniasis

The present study evaluates the potential of surface functionalized gelatin nanoparticles (f-GNPs) for efficient macrophage-specific delivery of amphotericin B (AmB) in the treatment of visceral leishmaniasis (VL). Further, the effect of spacer for macrophage targeting was also evaluated. Gelatin was functionalized either through conjugation to mannose via direct coupling (mGelatin) or via PEG spacer (m-Gelatin), and the synthesis was confirmed by FTIR. AmB-loaded f-GNPs, that is, mGNPs and m-GNPs prepared from mGelatin and m-Gelatin conjugates, respectively, were characterized. In vitro concanavalin A (Con-A) agglutination assay confirmed the availability of mannose on the surface of these f-GNPs. Kinetics of cellular uptake of AmB-loaded f-GNPs by J774A.1 macrophage cells assessed through flow cytometry demonstrated a steady increase and maximum cell-associated fluorescence was observed at 4h for m-GNPs and 6 h for m-GNPs. Measurement of cytotoxicity using Annexin-V–FITC/PI apoptosis assay delineated marginal changes (7–9%) in treated macrophages following 48 h incubation, establishing the safety of f-GNPs. m-GNPs showed a 5.4-fold reduction in IC50 in comparison with plain AmB suggesting significant enhancement of antileishmanial activity. Our results indicate that f-GNPs could be a promising carrier for specific delivery of AmB to macrophages for effective treatment of VL. Furthermore, spacer contributed significantly in reducing the cytotoxicity as well as increasing the uptake and activity of f-GNPs.
Relationship of neuropsychological performance to functional status in nursing home residents and community-dwelling older adults.

OBJECTIVES The authors examined the association between neuropsychological tests of executive functioning and episodic memory and functional disability in nursing home residents versus community-dwelling older adults. METHODS The neuropsychological performance of 96 residents from the Jewish Home and Hospital, Bronx, NY and 192 gender- and age-matched older adults from residential communities in the New York metropolitan area was assessed in eight tasks (Word List Recall, Delayed Recall, Recognition, Boston Naming, Verbal Fluency, Trailmaking A and B, and Digit Symbol Substitution). Functional status was derived from the Clinical Dementia Rating scale (CDR) extended activities of daily living scores. Regression analyses were performed to test for differences in cross-sectional age-gradients for cognitive and functional status between nursing home residents and community-dwellers. Furthermore, regression analyses, controlling for age, gender, dementia status, and education, were performed to determine the association between neuropsychological performance and functional status, comparing domains of executive functioning and memory. RESULTS Community-dwelling older adults showed age-related deficits both in overall cognitive status and functional disability, which were larger in nursing home residents. Executive functioning was associated with functional disability beyond the effects of age, gender, education, dementia status, residential status, overall cognitive status, memory, and cognitive speed. CONCLUSION Executive functioning is associated with functional deficits in both community-dwelling older adults and nursing home residents. Measures of executive functioning may prove useful in intervention studies aimed at delaying institutionalization.
LBH589 Inhibits Glioblastoma Growth and Angiogenesis Through Suppression of HIF-1&agr; Expression

Glioblastoma (GBM) is an angiogenic malignancy with a highly unfavorable prognosis. Angiogenesis in GBM represents an adaptation to a hypoxic microenvironment and is correlated with tumor growth, invasion, clinical recurrence, and lethality. LBH589 (also called panobinostat) is a histone deacetylase (HDAC) inhibitor with potent antitumor activity. In the current study, we investigated the mechanism and effects of LBH589 on GBM growth and hypoxia-induced angiogenesis in vitro and in vivo. To determine the antitumor and angiogenesis activity and mechanism of LBH589, we used cell proliferations in vitro and GBM xenografts in vivo. To clarify mechanisms of LBH589 on angiogenesis, HDAC assay, RT-PCR, Western blot, and co-immunoprecipitation assays were performed. We found LBH589 displayed significant antitumor effects on GBM as demonstrated by inhibited cell proliferation, slower tumor growth, and decreased microvessel density of subcutaneous xenografts. These actions of LBH589 resulted from the disruption of heat shock protein 90/HDAC6 complex, increased HIF-1α instability and degradation, and decreased VEGF expression. Our results indicate the potential antiangiogenic activity of LBH589 in human GBM and provide some preclinical data to warrant further exploration of HDAC inhibitors for the treatment of advanced glioma. Moreover, our study supports the role of HDAC inhibitors as a therapeutic strategy to target tumor angiogenesis.
Dielectric properties of Boron Nitride and silica epoxy composites

Epoxies are widely used materials, especially in high voltage insulation for its mechanical and dielectric properties. Boron Nitride is an attractive filler because of its high insulating properties associated with a high thermal conductivity. Nanometric Silica used as filler is actually widely studied in the literature and enhancement of dielectric breakdown and insulating properties has been shown. Using a combination of these two fillers in an epoxy matrix may produce a new material with improved properties. Samples containing only micrometric filler (Boron Nitride), only nanometric filler (Silica) and both fillers were prepared by gravity moulding. A pure epoxy sample was also prepared to quantify the enhancement properties. Broadband Dielectric Spectroscopy was used to study the influence of nanoparticles on the relaxation mechanisms in the composites. An additional relaxation peak was highlighted for samples containing nanosilica between the local β relaxation, associated with crankshaft motions of the hydroxylether groups, and the main α relaxation, corresponding to glass transition cooperative movements. This relaxation phenomenon was found to be associated with the water bounded at the surface of the silica particles. Further relaxation investigation will be performed to clarify the influence of water, its state and its role.
The Complex Relationship Between ADHD and Pediatric Sleep Disorders

Research Findings, 12 In the last decades, many studies have investigated the association between attention-deficit hyperactivity disorder (ADHD) and sleep problems, reported in a percentage ranging from 25% to 50% of cases (Corkum, Tannock, & Moldofsky, 1998). This relationship is still poorly understood because sleep problems include a wide range of specific sleep disorders, from insomnia to hypersomnia. Indeed, a better characterization and understanding of the specific sleep disorders underlying these complaints in children with ADHD is needed (Owens, 2005). The complexity of this issue is also due to the heterogeneity of the studies on sleep in pediatric ADHD (subjective studies based on sleep questionnaires fulfilled by caregivers or objective studies based on actigraphic and polysomnographic recordings), and the contradictory results reported. Caregivers are worried mostly about insomnia, bedtime resistance, difficulties with morning awakenings, snoring, and daytime sleepiness. Objective data showed an increase in sleep onset latency (actigraphic studies) or a decreased time to fall asleep during daytime with daytime somnolence (as measured by the Multiple Sleep Latency Test), a decreased amount of sleep time, an increased number of apneahypopnea during sleep and of movements during sleep (polysomnographic studies) (Cortese, Faraone, Konofal, & Lecendreux, 2009). Sleep instability in children with ADHD might also be a consequence of the increased rate of EEG-interictal discharges during sleep or of epilepsy (Silvestri et al., 2007). Finally, sleep-disordered breathing (SDB) is a well-known sleep disorder that is associated with diurnal neurobehavioral problems, such as ADHD, learning problems, behavioral disorders, and hypersomnolence. Intermittent hypoxia during sleep and sleep fragmentation due to sleep apnea are implicated in the pathogenesis of the diurnal neurobehavioral consequences of SDB (Kheirandish & Gozal, 2006). Paradoxically, while many studies have hypothesized the presence of an arousal dysfunction in ADHD, few data have been collected on the analysis of arousals in children with ADHD. The analysis of arousals has many clinical implications: An increased level of arousability might be related to sleep fragmentation, and excessive arousals from sleep may impair cognitive development, as well may low levels of arousability. Arousals are important components of sleep structure and are defined as transient intrusions of wakefulness during sleep and are closely correlated with the recovery function of sleep. Presented below is
Reducing Inappropriate Hospital Use on a General Pediatric Inpatient Unit

OBJECTIVE. Studies have documented high rates of inappropriate hospital use in children. We assessed the effectiveness of an audit-and-feedback intervention at reducing inappropriate hospital days on a general pediatric inpatient unit. METHODS. A prospective observational study, using a before-and-after design, was conducted at a tertiary care pediatric hospital in Canada between March 2005 and August 2006. The appropriateness of all hospital days for all admissions was evaluated by a nurse trained in using a utilization review tool. This tool classifies hospital days as “qualified” or “nonqualified” on the basis of the nature of the inpatient services that are used. Reasons for nonqualified days were classified. The intervention consisted of (1) weekly feedback to attending physicians of which patients were nonqualified and (2) dissemination of summary reports to attending physicians. Comparisons were made between the preintervention (March 2005 to August 2005) and intervention (March 2006 to August 2006) phases. RESULTS. The intervention was associated with a significantly lower risk of inappropriate hospital days. Of the 7246 hospital days in the 6-month intervention phase, 2413 (33%) were nonqualified versus 3859 (47%) of 8228 hospital days in the 6-month preintervention phase. A total of 7.35 hospital days would have to be reviewed, combined with weekly feedback, to prevent 1 nonqualified hospital day. The 48-hour readmission rate in the intervention phase and preintervention phase was 1.0% and 1.6%, respectively. The proportion of nonqualified days to total hospital days that were attributable to “finishing intravenous antibiotics,” “awaiting tests,” “providing nutrition,” “observation only,” “tapering treatment,” and “teaching” decreased significantly, whereas the “lack of an alternate level of care” increased significantly. CONCLUSIONS. An audit-and-feedback intervention directed at attending physicians was associated with a lower risk of inappropriate hospital days without an increase in the readmission rate. The utilization review tool also identified processes that impact on inappropriate hospital days.
Completeness of hospital cancer case reporting from the SEER program of the national cancer institute

Background. To ascertain the quality of data entering a population‐based reporting system, an essential requirement is to study levels of completeness of case‐ascertainment and reporting. This study represents an effort to quantify completeness of case reporting in the SEER (Surveillance, Epidemiology, and End Results) Program of the National Cancer Institute.
Risks for sensorimotor peripheral neuropathy and autonomic neuropathy in non‐insulin‐dependent diabetes mellitus (NIDDM)

Identification of risk factors for development of diabetic sensorimotor peripheral neuropathy (DSPN) and diabetic autonomic neuropathy (DNA) may help to prevent or modify these complications. The ABCD Trial, a prospective study of diabetic complications, has identified risk factors of the presence and staging of peripheral neuropathy based on neurological symptom scores, neurological disability scores, autonomic function testing and quantitative sensory examination. DSPN is independently associated with diabetes duration [odds ratio (OR) = 1.5 per 10 years], body weight (OR = 1.1 per 5 kg), age (OR = 1.8 per 10 years), retinopathy (OR = 2.3), overt albuminuria (OR = 2.5), height (OR = 1.2 per 10 cm), duration of hypertension (OR = 1.1 per 10 years), insulin use (OR = 1.4), and race/ethnicity [African American vs. non‐Hispanic white (OR = 0.4) and Hispanic vs. non‐Hispanic white (OR = 0.8)]. DAN is independently associated with diabetes duration (OR = 1.2 per 10 years), body weight (OR = 1.1 per 5 kg), glycosylated hemoglobin (OR = 1.1 per 2.5%), overt albuminuria (OR = 1.6), and retinopathy (OR = 1.8). © 1998 John Wiley & Sons, Inc. Muscle Nerve, 21: 72–80, 1998.
A pilot study of angiogenin in heart failure with preserved ejection fraction: a novel potential biomarker for diagnosis and prognosis?

Characteristics of heart failure with preserved ejection fraction (HFPEF) have not yet been fully understood. The objectives of this pilot study are to detect protein expression profile in the sera of HFPEF patients, and to identify potential biomarkers for the disease. Five hundred and seven proteins were detected in the sera of healthy volunteers and patients with either HFPEF or hypertension using antibody microarrays (three in each group). The results showed that the serum concentrations of 17 proteins (e.g. angiogenin, activin A and artemin) differed considerably between HFPEF and non‐HFPEF patients (hypertensive patients and healthy controls), while a protein expression pattern distinct from that in non‐HFPEF patients was associated with HFPEF patients. The up‐regulation of angiogenin in both HFPEF patients with LVEF ≥50% (P = 0.004) and a subset of HFPEF patients with LVEF = 41–49% (P < 0.001) was further validated in 16 HFPEF patients and 16 healthy controls. Meanwhile, angiogenin distinguished HFPEF patients from controls with a mean area under the receiver operating characteristic curve of 0.88 (P < 0.001) and a diagnostic cut‐off point of 426 ng/ml. Moreover, the angiogenin levels in HFPEF patients were positively correlated with Lg(N‐terminal pro‐B‐type natriuretic peptide, NT‐proBNP) (P < 0.001). In addition, high angiogenin level (≥426 ng/ml) was a predictor of all‐cause death within a short‐term follow‐up duration, but not in the longer term of 36 months. This pilot study indicates that the aforementioned 17 potential biomarkers, such as angiogenin, may hold great promise for both diagnosis and prognosis assessment of HFPEF.
Emotional rescue: the role of emotional intelligence and emotional labour on well-being and job-stress among community nurses.

AIMS To investigate the extent to which emotional labour and emotional intelligence are associated with well-being and job-stress among a group of Australian community nurses. The moderating role of emotional intelligence was evaluated as a key factor in the rescue of healthcare workers from job-stress, thus increasing job retention. BACKGROUND Although emotional labour has been broadly investigated in the literature, the contribution of emotional labour and emotional intelligence to the well-being and experience of job-stress in a community nursing setting requires further exploration. DESIGN This study used a cross-sectional quantitative research design with data collected from Australian community nurses. METHODS Australian community nurses (n = 312) reported on their perceived emotional labour, emotional intelligence and their levels of well-being and job-stress using a paper and pencil survey in 2010. RESULTS/FINDINGS Results from structural equation modelling support the hypothesis that both emotional labour and emotional intelligence have significant effects on nurses' well-being and perceived job-stress. Emotional intelligence plays a moderating role in the experience of job-stress. CONCLUSION These findings provide additional evidence for the important effects that emotional labour and emotional intelligence can have on well-being and job-stress among community nurses. The potential benefits of emotional intelligence in the nurses' emotional work have been explored.
Relations between mindfulness and mental health outcomes: need fulfillment as a mediator

Links between mindfulness and mental health outcomes have been established, but the explanatory mechanisms responsible for these associations are far less understood. This study examined relationships between mindfulness, need fulfillment and mental health outcomes (negative affect and depressive symptoms). The primary purpose of this paper was to, first, verify the link between mindfulness and mental health outcomes, and second, to better understand and explain why mindfulness is important for mental health outcomes. Specifically, this study sought to examine the potential mediating influence of need fulfillment in the relationship between mindfulness and mental health outcomes. A sample of 399 university students and employees responded to an online survey. Data were collected on personal ratings of trait mindfulness, need fulfillment, negative affect and depressive symptoms. Results indicated a significant positive relationship between mindfulness and need fulfillment, and these variables were negatively associated with poor mental health outcomes (negative affect and depressive symptoms). Further, it was found that need fulfillment partially mediated the relationship between mindfulness and both mental health outcomes. Specific facets of need fulfillment (i.e., belongingness, self-esteem, control, meaningful existence) were also explored individually as potential mediators to determine which facet accounted for the greatest variance in the relationship between mindfulness and mental health outcomes. In doing so, this study helps clarify the relations between mindfulness and mental health outcomes. Results from this study extend the current literature of mindfulness and further inform the implementation of clinical mindfulness techniques and strategies.