Miracle-dz/UniFAR-FTUs huggingface dataset:
Adult Male Individuation: An Examination

The understanding of an adult individuation process similar to the developmental transitions experienced during infancy and again during the adolescent years emerges through the integration and assessment of Life Span Developmental Psychology research. Adulthood is a period in which true individuation and adaptative disillusionment begin, freeing the self not from parental omnipotence, as seen in the earlier individuation periods, but from societal demands and the individual's own repressed instinctual drives and needs. The understanding of this transition with its behavioral presentations offers fresh clinical insights into the psychology of the middle-age adult C. G. Jung was one of the earliest behavioral scientists to contemplate that intra-individual variability as well as intra-individual invariance constitute the natural state of the adult psyche. His notion of Individuation encompasses the supranatural aspects of the unconscious and probes beyond the presenting persona. This study examines the behavioral presentation during the mid-life male maturation process as it intercepts with the Individuation process. From longitudinal data supplied by the Institute of Human Development Guidance Study, University of California, Berkeley, California, forty male subjects were grouped by Individuation attainment at age thirty and forty years through the correlation of subject Q-data (compiled at 30 and 40 years of age) to an established Criterion Q-Index. Three Jungian analysts established the consensual-based Criterion Q description of male Individuation as derived from the Jungian perspective. Subjects were classified into three subgroups (Most Characteristic, Least Characteristic, and Neutral) representing the change ofIndividuation attainment between thirty and forty years of age. Thirteen personality traits from longitudinal Personality Assessment ratings supplied the primary descriptive variables. The personality traits were derived from Personality Appraisal data within the 1HD Study where replication was discovered at age thirty and forty. Descriptive traits were: Level of Frankness; Demonstrativeness; Anger; Emotional Dependency; Seriousness; Changeability; Worry; Socialization; Orderliness; Introversion; Self Confidence; Emotional Stability; and Marital Adjustment Group means significance testing through a matched pairs t-ratio was the primary statistic. Design goals were descriptive and hypothesis-generating. During the time frame in question, the psychosocial variables of dependency, socialization, structural-environmental care, self confidence and emotional stability show as significant and assist in group attainment delineation. Subjects most Individuated became more even-keeled in the presentation of self and showed an increase in social skills with less rigidity. Subjects least Individuated were still struggling with issues of dependency and other-directedness and also declined in emotional stability.
Sphingosine-1-Phosphate Receptor-2 Regulates Expression of Smooth Muscle Alpha-Actin After Arterial Injury

Objective—This study tests the hypothesis that S1P2R regulates expression of SMC differentiation genes after arterial injury. Methods and Results—Carotid ligation injury was performed in wild-type and S1P2R-null mice. At various time points after injury, expression of multiple SMC differentiation genes, myocardin, and S1P receptors (S1P1R, S1P2R, and S1P3R) was measured by quantitative PCR. These experiments demonstrate that at day 7 after injury, S1P2R specifically regulates expression of smooth muscle α-actin (SMA) and that this is not mediated by changes in expression of myocardin or any of the S1PRs. In vitro studies using carotid SMCs prepared from wild-type and S1P2R-null mice show that S1P stimulates expression of all SMC-differentiation genes tested, but S1P2R significantly regulates expression of SMA and SM22α only. Chromatin immunoprecipitation assays suggest that S1P-induced recruitment of serum response factor to the SMA promoter and enhancer largely depends on S1P2R. S1P-stimulated SMA expression requires S1P2R-dependent activation of RhoA and mobilization of calcium from intracellular stores. Chelation of calcium does not affect the activation of RhoA by S1P, whereas blockade of Rho by C3 exotoxin partially inhibits the mobilization of calcium by S1P. Conclusions—The results of this study support the hypothesis that S1P2R regulates expression of SMA after injury. We further conclude that transcriptional regulation of SMA by S1P in vitro requires S1P2R-dependent activation of RhoA and mobilization of calcium from intracellular calcium stores.
Erfassung des kognitiven Entwicklungsumfeldes von türkisch-deutschen Kleinkindern

Die HOME Skala (Home Observation Measurement for Environment) von Caldwell und Bradley wird weltweit am haufigsten zur Erfassung des Entwicklungskontextes von Sauglingen und Kleinkindern. Die Autorin entwickelte kulturspezifische Zusatzitems fur die Erfassung des Entwicklungskontextes turkisch-deutscher Kleinkinder in Deutschland mit dem Ziel, uber die Verbesserung der inhaltlichen Validitat eine Erhohung der Kriteriumsvaliditat der HOME Skala fur diese Gruppe zu erreichen. In einer Validierungsstudie wurden die originalen HOME Items und die Zusatzitems in 36 Migrationsfamilien turkischer Herkunft und 35 deutschen Familien mit 12 Monate alten Sauglingen eingesetzt.
Fast sampling from a Hidden Markov Model posterior for large data

Hidden Markov Models are of interest in a broad set of applications including modern data driven systems involving very large data sets. However, approximate inference methods based on Bayesian averaging are precluded in such applications as each sampling step requires a full sweep over the data. We show that Approximate Bayesian Computation offers an interesting alternative for approximate sampling from the posterior distribution. In particular we use recent advances in moment based methods for HMM estimation to generate summary statistics for Approximate Bayesian Computation for large data sets offering fast access to approximate posterior samples. In a specific example we see that the new scheme is a hundred times faster than conventional Markov Chain Monte Carlo sampling using the Forward-backward method.
A High Burden of Respiratory Syncytial Virus Associated Pneumonia in Children Less than Two Years of Age in a South East Asian Refugee Population

Background Pneumonia is a major cause of childhood mortality and morbidity approximately 1.6 million deaths and 150 million episodes occur annually in children <5 years. Respiratory syncytial virus (RSV) may be responsible for up to 25% of cases and 12% of deaths making it an important potential vaccine target, although data from South East Asia is scarce. Methods We followed a birth cohort of Burmese refugee children, born over a one year period, for two years. Pneumonia episodes were diagnosed using WHO criteria. A chest radiograph, nasopharyngeal aspirate and non-specific markers of infection were taken during each episode. Results The incidence of RSV-associated pneumonia was 0.24 (95% CI 0.22–0.26) episodes per child year. All children with pneumonia received antibiotic treatment, following WHO guidelines. The highest incidence was in the 2–12 month age group. The commonest diagnosis in a child with RSV-associated pneumonia was non-severe pneumonia (239/362∶66.0%), however the incidence of RSV-associated severe or very severe pneumonia was 0.08 (95% CI 0.01–0.10) episodes per child year. Birth in the wet season increased the risk of severe disease in children who had their first episode of RSV-associated pneumonia aged 2–11 months (OR 28.7, 95% CI 6.6–125.0, p<0.001). RSV episodes were highly seasonal being responsible for 80.0% of all the pneumonia episodes occurring each October and November over the study period. Conclusions There was a high incidence of RSV associated pneumonia in this refugee population. Interventions to prevent RSV infection have the potential to reduce the incidence of clinically diagnosed pneumonia and hence unnecessary antibiotic usage in this population.
A predictive model for the passenger demand on a taxi network

In the last decade, the real-time vehicle location systems attracted everyone attention for the new kind of rich spatio-temporal information. The fast processing of this large amount of information is a growing and explosive challenge. Taxi companies are already exploring such information in efficient taxi dispatching and time-saving route finding. In this paper, we propose a novel methodology to produce online short term predictions on the passenger demand spatial distribution over 63 taxi stands in the city of Porto, Portugal. We did so using time series forecasting techniques to the processed events constantly communicated for 441 taxi vehicles. Our tests - using 4 months of real data - demonstrated that this model is a true major contribution to the driver mobility intelligence: 76% of the 86411 demanded taxi services were accurately forecasted in a 30 minutes time horizon.
Effects of dopamine receptor agonists on food intake and rumen motility in dwarf goats.

In ruminants, the dopaminergic regulation of feeding behaviour has not been investigated. Therefore, the effects of dopamine receptor agonists and antagonists on food intake and forestomach motility were studied in dwarf goats. Goats treated i.v. with bromocriptine (1 micrograms or 2.5 micrograms/kg body wt/min during 10 min) ate less food than when treated with saline. This inhibitory effect on food intake could not be prevented by the peripheral dopamine receptor antagonist domperidone (0.5 mg/kg body wt i.v.). In contrast, dopamine (i.v. 20 micrograms/kg body wt/min during 15 min), levodopa (i.v. 40 micrograms/kg body weight during 10 min), apomorphine (i.v. 2 micrograms/kg body wt/min during 10 min) and lisuride (i.v. 0.2 microgram/kg body wt/min during 15 min and 0.5 microgram/kg body wt during 10 min) failed to modify food intake. Given in association with benserazide, a decarboxylase inhibitor (i.v. 20 micrograms/kg body wt/min during 10 min), levodopa was still inactive as an anorectic agent. Levodopa, bromocriptine and lisuride administered at similar dose rates to those which were used in the food intake experiments, induced some clinical signs including inhibition of forestomach contractions. The inhibition of rumen contractions induced by these drugs was completely antagonized by domperidone pretreatment. These results, together with earlier in vivo and in vitro observations, suggest that the inhibitory effects of dopamine receptor agonists on forestomach contractions are due to interactions with peripheral dopaminergic receptors. The change in smooth muscle tension, which leads to a change in the signals transmitted via vagal afferents to the central nervous system, probably does not modify feeding behaviour in dwarf goats. (ABSTRACT TRUNCATED AT 250 WORDS)
Are Cytomegalic Neurons and Balloon Cells Generators of Epileptic Activity in Pediatric Cortical Dysplasia?

Summary: Purpose: Severe cortical dysplasia (CD) is characterized by the presence of cytomegalic neurons and balloon cells. These aberrant cells could participate in the generation of epileptic activity. The aim of this study was to morphologically and electrophysiologically characterize cells in pediatric CD tissue.
Rhizobium rosettiformans sp. nov., isolated from a hexachlorocyclohexane dump site, and reclassification of Blastobacter aggregatus Hirsch and Muller 1986 as Rhizobium aggregatum comb. nov.

A Gram-negative, rod-shaped, motile, aerobic bacterial strain, W3(T), was isolated from hexachlorocyclohexane (HCH)-contaminated groundwater from Lucknow, India, and its taxonomic position was determined using a polyphasic approach. Strain W3(T) shared highest 16S rRNA gene sequence similarity of 97.8 % with Rhizobium selenitireducens B1(T), followed by Rhizobium daejeonense L61(T) (97.7 %), Rhizobium radiobacter ATCC 19358(T) (97.5 %) and Blastobacter aggregatus IFAM 1003(T) (97.2 %). Strain W3(T) formed a monophyletic clade with Blastobacter aggregatus IFAM 1003(T) ( = DSM 1111(T)) in the cluster of species of the genus Rhizobium. Phylogenetic analyses of strain W3(T) using atpD and recA gene sequences confirmed the phylogenetic arrangements obtained by using 16S rRNA gene sequences. Hence, the taxonomic characterization of B. aggregatus DSM 1111(T) was also undertaken. Strains W3(T) and B. aggregatus DSM 1111(T) contained summed feature 8 (18 : 1ω7c and/or 18 : 1ω6c; 65.4 and 70.8 %, respectively) as the major fatty acid, characteristic of the genus Rhizobium. DNA-DNA relatedness of strain W3(T) with Rhizobium selenitireducens LMG 24075(T), Rhizobium daejeonense DSM 17795(T), Rhizobium radiobacter DSM 30147(T) and B. aggregatus DSM 1111(T) was 42, 34, 30 and 34 %, respectively. The DNA G+C contents of strain W3(T) and B. aggregatus DSM 1111(T) were 62.3 and 62.7 mol%, respectively. A nifH gene encoding dinitrogenase reductase was detected in strain W3(T) but not in B. aggregatus DSM 1111(T). Based on the results obtained by phylogenetic and chemotaxonomic analyses, phenotypic characterization and DNA-DNA hybridization, it is concluded that strain W3(T) represents a novel species of the genus Rhizobium, for which the name Rhizobium rosettiformans sp. nov. is proposed (type strain W3(T) = CCM 7583(T) = MTCC 9454(T)). It is also proposed that Blastobacter aggregatus Hirsch and Müller 1986 be transferred to the genus Rhizobium as Rhizobium aggregatum comb. nov. (type strain IFAM 1003(T) = DSM 1111(T) = ATCC 43293(T)).
Thy-1 Signaling in the Context of Costimulation Provided by Dendritic Cells Provides Signal 1 for T Cell Proliferation and Cytotoxic Effector Molecule Expression, but Fails to Trigger Delivery of the Lethal Hit1

Cross-linking of the GPI-anchored protein Thy-1 results in T cell proliferation and IL-2 synthesis. However, the exact function of Thy-1 in the process of T cell activation remains unknown, as does the effect of costimulation on Thy-1-driven T cell responses. In this study, we have investigated the ability of Thy-1 to substitute for traditional signal 1 in the context of costimulation provided by dendritic cells. Dendritic cells dramatically enhanced T cell proliferation and IL-2 synthesis in response to Thy-1 triggering by anti-Thy-1 mAb. This effect was not dependent on dendritic cell Fcγ receptors, but was a result of B7-mediated costimulation (signal 2). T cells were also activated when microbeads coated with a combination of anti-Thy-1 and anti-CD28 mAbs were used to supply signals 1 and 2, respectively. Thy-1-stimulated T cells adhere to target cells and express perforin, granzyme B, and Fas ligand, but fail to kill target cells due to an inability to reorganize their secretion machinery. Moreover, in contrast to TCR signaling, Thy-1 triggering failed to induce cytotoxicity in redirected lysis assays. We conclude that Thy-1 triggering can partially substitute for signal 1, which, in combination with a strong signal 2, leads to robust T cell proliferation, IL-2 synthesis, and cytotoxic effector molecule expression, but does not induce cytolytic function. The block at the level of cytotoxic effector function that results when T cells are activated in the absence of a classical, Ag-specific signal 1 may constitute a mechanism to ensure the specificity of CTL responses and prevent potentially harmful promiscuous cytotoxicity.
Fed-Batch Cell Culture Process Optimization A Rationally Integrated Approach

level: intermediAte Most biopharmaceutical production platforms are based on fed-batch cell culture protocols, which can support high volumetric productivity while maintaining low operational complexity (1). The industry is interested in developing or refining high-titer cell culture processes to meet increasing market demands and reduce manufacturing costs (2). Although advancements in cell engineering have enabled development of highperforming recombinant cell lines (3–6), improvements in cell culture media and process parameter settings are required to realize the maximum production potentials of those cells (7–8). In a fed-batch process, a basal medium supports initial growth and production, and a feed medium prevents depletion of nutrients and sustains the production phase (9). Those media can contain different assortments of nutrients to accommodate the distinct metabolic requirements during different production phases. Process parameter settings — including feeding strategy and control parameters — define the chemical and physical environments suitable for cell growth and protein production. Optimization of a fedbatch process can be achieved by development efforts addressing one or more of three major elements: basal medium, feed medium, and process settings. Given the large sets of variables in these systems, establishing a costand time-efficient approach for process optimization is desired but challenging. Through a study aiming to upgrade a fed-batch process, we observed that basal and feed media have interrelated impacts on process outcomes (a “pairing effect”). So we required a combined optimization of basal and feed media to fulfill our objective. Here we discuss a rationally integrated approach that best serves the practices of fed-batch cell culture process optimization.
Management of lymphangioleiomyomatosis

Lymphangioleiomyomatosis (LAM), a multisystem disease affecting almost exclusively women, is characterized by cystic lung destruction and presents with dyspnea, recurrent pneumothoraxes, chylous effusions, lymphangioleiomyomas, and angiomyolipomas. It is caused by the proliferation of a cancer-like LAM cell that possesses a mutation in either the tuberous sclerosis complex (TSC)1 or TSC2 genes. This article reviews current therapies and new potential treatments that are currently undergoing investigation. The major development in the treatment of LAM is the discovery of two mammalian target of rapamycin (mTOR) inhibitors, sirolimus and everolimus, as effective drugs. However, inhibition of mTOR increases autophagy, which may lead to enhanced LAM cell survival. Use of autophagy inhibitors, for example, hydroxychloroquine, in combination with sirolimus is now the subject of an ongoing drug trial (SAIL trial). Another consequence of mTOR inhibition by sirolimus is an increase in Rho activity, resulting in reduced programmed cell death. From these data, the concept evolved that a combination of sirolimus with disruption of Rho activity with statins (e.g. simvastatin) may increase TSC-null cell death and reduce LAM cell survival. A combined trial of sirolimus with simvastatin is under investigation (SOS trial). Since LAM occurs primarily in women and TSC-null cell survival and tumor growth is promoted by estrogens, the inhibition of aromatase to block estrogen synthesis is currently undergoing study (TRAIL trial). Other targets, for example, estrogen receptors, mitogen-activated protein kinase inhibitors, vascular endothelial growth factor-D signaling pathway, and Src kinase, are also being studied in experimental model systems. As in the case of cancer, combination therapy may become the treatment of choice for LAM.
A high-performance application data environment for large-scale scientific computations

Effective high-level data management is becoming an important issue with more and more scientific applications manipulating huge amounts of secondary-storage and tertiary-storage data using parallel processors. A major problem facing the current solutions to this data management problem is that these solutions either require a deep understanding of specific data storage architectures and file layouts to obtain the best performance (as in high-performance storage management systems and parallel file systems), or they sacrifice significant performance in exchange for ease-of-use and portability (as in traditional database management systems). We discuss the design, implementation, and evaluation of a novel application development environment for scientific computations. This environment includes a number of components that make it easy for the programmers to code and run their applications without much programming effort and, at the same time, to harness the available computational and storage power on parallel architectures.
The development of the nucleus isthmi in Xenopus laevis. I. Cell genesis and the formation of connections with the tectum

The nucleus isthmi (NI) of the amphibian relays visual input from one tectum to the other tectum and thus brings a visual map from the eye to the ipsilateral tectum. This isthmotectal visual map develops slowly; it is first detected electrophysiologically at stages 60–62, the age at which the eyes begin their dorsalward migration and the region of binocular overlap begins to increase in extent. During this critical period of life, normal binocular visual input is required for establishment of normal topographic isthmotectal projections. In this study, we have used anatomical methods to trace cell birth, cell death, and formation of connections by the nucleus isthmi during the critical period.
C V ] 7 F eb 2 01 8 IMAGE FORGERY LOCALIZATION BASED ON MULTI-SCALE CONVOLUTIONAL NEURAL NETWORKS

In this paper, we propose to utilize Convolutional Neural Networks (CNNs) and the segmentation-based multi-scale analysis to locate tampered areas in digital images. First, to deal with color input sliding windows of different scales, a unified CNN architecture is designed. Then, we elaborately design the training procedures of CNNs on sampled training patches. With a set of robust multi-scale tampering detectors based on CNNs, complementary tampering possibility maps can be generated. Last but not least, a segmentation-based method is proposed to fuse the maps and generate the final decision map. By exploiting the benefits of both the smallscale and large-scale analyses, the segmentation-based multiscale analysis can lead to a performance leap in forgery localization of CNNs. Numerous experiments are conducted to demonstrate the effectiveness and efficiency of our method.