Miracle-dz/UniFAR-FTUs huggingface dataset:
In vivo visualization of lipid coronary atheroma with intravascular near-infrared spectroscopy

ABSTRACT Introduction: Atherosclerotic cardiovascular disease (ASCVD) has become a major health burden and is expected to further increase in the future. Better predictive approaches for ASCVD and more efficacious therapies are required to further improve cardiovascular outcomes. Intravascular imaging has contributed to the elucidation of atherosclerotic mechanisms and evaluation of novel therapies. Near-infrared spectroscopy has enabled the visualization of the lipid extent of atherosclerotic plaques in vivo. Given that lipid accumulation is considered to promote the formation and progression of atherosclerosis, this technology may harbor the potential to identify subjects with high cardiovascular risks and thus adopt more optimized therapeutic approaches. Areas covered: This review will outline the characteristics of NIRS, its validation data and in vivo findings of NIRS imaging in patients with coronary artery disease. The comparisons of NIRS with other imaging modalities will reveal the distinct capability of NIRS imaging to monitor high-risk atheroma harboring lipidic composition. Furthermore, the predictive ability of NIRS-derived measures in the occurrence of ASCVD will be summarized. Expert commentary: Ex vivo and in vivo findings suggest NIRS imaging as a potential tool for cardiovascular risk assessment and monitoring the benefit of pharmacological approaches.
Inference of financial networks using the normalised mutual information rate

In this paper, we study data from financial markets, using the normalised Mutual Information Rate. We show how to use it to infer the underlying network structure of interrelations in the foreign currency exchange rates and stock indices of 15 currency areas. We first present the mathematical method and discuss its computational aspects, and apply it to artificial data from chaotic dynamics and to correlated normal-variates data. We then apply the method to infer the structure of the financial system from the time-series of currency exchange rates and stock indices. In particular, we study and reveal the interrelations among the various foreign currency exchange rates and stock indices in two separate networks, of which we also study their structural properties. Our results show that both inferred networks are small-world networks, sharing similar properties and having differences in terms of assortativity. Importantly, our work shows that global economies tend to connect with other economies world-wide, rather than creating small groups of local economies. Finally, the consistent interrelations depicted among the 15 currency areas are further supported by a discussion from the viewpoint of economics.
Joint Power and Trajectory Design for Physical-Layer Secrecy in the UAV-Aided Mobile Relaying System

Mobile relaying is emerged as a promising technique to assist wireless communication, driven by the rapid development of unmanned aerial vehicles. In this paper, we study secure transmission in a four-node (source, destination, mobile relay, and eavesdropper) system, wherein we focus on maximizing the secrecy rate via jointly optimizing the relay trajectory and the source/relay transmit power. Nevertheless, due to the coupling of the trajectory designing and the power allocating, the secrecy rate maximization problem is intractable to solve. Accordingly, we propose an alternating optimization approach, wherein the trajectory designing and the power allocating are tackled in an alternating manner. Unfortunately, the trajectory designing is a nonconvex problem, and thus, it is still hard to solve. To circumvent the nonconvexity, we exploit sequential convex programming to derive an iterative algorithm, which is proven to converge to a Karush–Kuhn–Tucker point of the trajectory design problem. The simulation results demonstrate the efficacy of the joint power and trajectory design in improving the secrecy throughput.
Calf and colostrum management practices on New Zealand dairy farms and their associations with concentrations of total protein in calf serum

AIMS: To gather information on management practices and farmer attitudes to management of cows and calves during the immediate post-partum period on dairy farms in New Zealand, and to assess these practices for associations with concentrations of total protein (TP) in serum of calves 1–8 days-old. METHOD: Between July and September 2015 blood samples were collected from calves aged between 24 hours and 7 days, from dairy farms (n=105) in nine areas in New Zealand, on three occasions throughout the calving period. Concentrations of TP were determined in all serum samples. At each visit technicians collected 1 L of the pooled colostrum that was intended for feeding to newborn calves that day. These samples were assessed for Brix, coliform and total bacterial counts. After the last sampling visit, the calf rearer or farm manager were asked to complete a questionnaire describing calf and colostrum management practices on the farm. Potential farm-level variables associated with concentrations of TP in serum of sampled calves were identified using univariable and multivariable linear mixed models. RESULTS: Mean concentration of TP in serum of calves across all farms was 59.8 (95% CI=59.4–60.2) g/L, and was associated with region and herd size in the final multivariable model. Concentrations of TP were lower in calves from farms in Otago (56.2 (95% CI=53.4–58.9) g/L) and Southland (56.9 (95% CI=54.1–59.7) g/L) compared to calves on farms in the Far North (62.6 (95% CI=59.8–65.3) g/L), and were lower in calves from farms with a herd size >600 (58.3 (95% CI=56.7–59.8) g/L) than ≤600 (61.3 (95% CI=60.1–62.5) g/L) cows. After accounting for fixed effects, farm accounted for only 8.4% of the unexplained variation. There was no association between any of the measures of colostrum quality and concentrations of TP in serum (p>0.2). CONCLUSION AND CLINICAL RELEVANCE: Very few herd-level variables were associated with concentrations of TP in serum. Risk factors that have been shown to be of importance in previous studies outside New Zealand were not identified as important in the current study. It is possible that, in the situation where calves are kept at pasture with their dams for prolonged periods, variables which influence how well a cow can feed its calf in the first 12–24 hours have a larger influence on concentrations of TP in serum than the collection and management of calves once they reach the rearing shed.
Packing and covering induced subdivisions

A graph class $\mathcal{F}$ has the induced Erd\H{o}s-P\'osa property if there exists a function $f$ such that for every graph $G$ and every positive integer $k$, $G$ contains either $k$ pairwise vertex-disjoint induced subgraphs that belong to $\mathcal{F}$, or a vertex set of size at most $f(k)$ hitting all induced copies of graphs in $\mathcal{F}$. Kim and Kwon (SODA'18) showed that for a cycle $C_{\ell}$ of length $\ell$, the set of $C_{\ell}$-subdivisions has the induced Erd\H{o}s-P\'osa property if and only if $\ell\le 4$. In this paper, we investigate whether subdivisions of $H$ have the induced Erd\H{o}s-P\'osa property for other graphs $H$. We completely settle the case where $H$ is a forest or a complete bipartite graph. Regarding the general case, we identify necessary conditions on $H$ for its subdivisions to have the induced Erd\H{o}s-P\'osa property. For this, we describe three basic constructions that can be used to prove that subdivisions of a graph do not have the induced Erd\H{o}s-P\'osa property. Among remaining graphs, we prove that the subdivisions of the diamond, the 1-pan, and the 2-pan have the induced Erd\H{o}s-P\'osa property.
Development of Feeding Cues During Infancy and Toddlerhood

Purpose:To enhance responsive feeding, this study aimed to characterize the development of feeding cues during infancy and toddlerhood. Study Design and Methods:A secondary analysis was performed on a dataset of first-time, low-income African American mother–infant pairs assessed at infant age 3, 6, 9, 12, and 18 months. A subsample with the 15 highest, middle, and lowest infant body mass index (BMI) Z-scores at 18 months was selected (n = 45). Using video-recorded home feedings, early, active, and late receptiveness and fullness cues were assessed using the Responsiveness to Child Feeding Cues Scale at each time point. Descriptive statistics were used to characterize development. Results:Early receptiveness cues were relatively rare over time, whereas active receptiveness cues were much more common. However, there were changes over time. For example, settling into the feeding decreased from ~50% at 3 and 6 months to 4.8% by 18 months, whereas postural attention and reaching for food increased after 6 months. In the first 6 months, falling asleep and decreasing muscle tone and activity level were the most common early fullness cues. Thereafter, taking interest in surroundings was most prevalent. Active fullness cues became increasingly diverse after 6 months, led by more assertive cues such as pushing or pulling away and communicating “no” verbally or nonverbally. Clinical Implications:These findings provide an empirical description of waxing and waning in feeding cues and indicate increasing intentionality of cues over the first 18 months of life. Knowing common cues across development may aid clinicians in enhancing parental feeding responsiveness, avoiding overfeeding, thereby decreasing risk of early childhood obesity.
Resveratrol Inhibits the Epithelial Sodium Channel via Phopshoinositides and AMP-Activated Protein Kinase in Kidney Collecting Duct Cells

Resveratrol, a naturally occurring phytoalexin, has reported cardioprotective, anti-inflammatory, chemopreventative and antidiabetic properties. Several studies indicate the multiple effects of resveratrol on cellular function are due to its inhibition of class 1A phosphoinositide 3-kinase (PI3K) mediated signaling pathways, but it also activates AMP-activated protein kinase (AMPK). As sodium transport in the kidney via the Epithelial Sodium Channel (ENaC) is highly sensitive to changes in phosphoinositide signaling in the membrane and AMPK, we employed resveratrol to probe the relative effects of phosphatidylinositol species in the plasma membrane and AMPK activity and their impact on ENaC activity in mouse cortical collecting duct (mpkCCDc14) cells. Here we demonstrate that resveratrol acutely reduces amiloride-sensitive current in mpkCCDc14 cells. The time course and dose dependency of this inhibition paralleled depletion of the PI(3,4,5)P3 reporter (AKT-PH) in live-cell microscopy, indicating the early inhibition is likely mediated by resveratrol's known effects on PI3K activity. Additionally, resveratrol induces a late inhibitory effect (4–24 hours) that appears to be mediated via AMPK activation. Resveratrol treatment induces significant AMPK activation compared with vehicle controls after 4 h, which persists through 16 h. Knockdown of AMPK or treatment with the AMPK inhibitor Compound C reduced the late phase of current reduction but had no effect on the early inhibitory activity of resveratrol. Collectively, these data demonstrate that resveratrol inhibits ENaC activity by a dual effect: an early reduction in activity seen within 5 minutes related to depletion of membrane PIP3, and a sustained late (4–24 h) effect secondary to activation of AMPK.
ConMap: A Novel Framework for Optimizing Multicast Energy in Delay-constrained Mobile Wireless Networks

This paper studies the problem of optimizing multicast energy consumption in delay-constrained mobile wireless networks, where information from the source needs to be delivered to all the k destinations within an imposed delay constraint. Most existing works simply focus on deriving transmission schemes with the minimum transmitting energy, overlooking the energy consumption at the receiver side. Therefore, in this paper, we propose ConMap, a novel and general framework for efficient transmission scheme design that jointly optimizes both the transmitting and receiving energy. In doing so, we formulate our problem of designing minimum energy transmission scheme, called DeMEM, as a combinatorial optimization one, and prove that the approximation ratio of any polynomial time algorithm for DeMEM cannot be better than ¼ ln k. Aiming to provide more efficient approximation schemes, the proposed ConMap first converts DeMEM into an equivalent directed Steiner tree problem through creating auxiliary graph gadgets to capture energy consumption, then maps the computed tree back into a transmission scheme. The advantages of ConMap are threefolded: i) Generality-- ConMap exhibits strong applicability to a wide range of energy models; ii) Flexibility-- Any algorithm designed for the problem of directed Steiner tree can be embedded into our ConMap framework to achieve different performance guarantees and complexities; iii) Efficiency-- ConMap preserves the approximation ratio of the embedded Steiner tree algorithm, to which only slight overhead will be incurred. The three features are then empirically validated, with ConMap also yielding near-optimal transmission schemes compared to a brute-force exact algorithm. To our best knowledge, this is the first work that jointly considers both the transmitting and receiving energy in the design of multicast transmission schemes in mobile wireless networks.
Propagation of registration uncertainty during multi-fraction cervical cancer brachytherapy

Multi-fraction cervical cancer brachytherapy is a form of image-guided radiotherapy that heavily relies on 3D imaging during treatment planning, delivery, and quality control. In this context, deformable image registration can increase the accuracy of dosimetric evaluations, provided that one can account for the uncertainties associated with the registration process. To enable such capability, we propose a mathematical framework that first estimates the registration uncertainty and subsequently propagates the effects of the computed uncertainties from the registration stage through to the visualizations, organ segmentations, and dosimetric evaluations. To ensure the practicality of our proposed framework in real world image-guided radiotherapy contexts, we implemented our technique via a computationally efficient and generalizable algorithm that is compatible with existing deformable image registration software. In our clinical context of fractionated cervical cancer brachytherapy, we perform a retrospective analysis on 37 patients and present evidence that our proposed methodology for computing and propagating registration uncertainties may be beneficial during therapy planning and quality control. Specifically, we quantify and visualize the influence of registration uncertainty on dosimetric analysis during the computation of the total accumulated radiation dose on the bladder wall. We further show how registration uncertainty may be leveraged into enhanced visualizations that depict the quality of the registration and highlight potential deviations from the treatment plan prior to the delivery of radiation treatment. Finally, we show that we can improve the transfer of delineated volumetric organ segmentation labels from one fraction to the next by encoding the computed registration uncertainties into the segmentation labels.
Dynamic Assessment fo Biocidal Properties ofSilicon-Chitosan -Containing Hydrogels

Our researches were focused on the study of the possibility to use the Silicon-chitosancontaining hydrogels as the more active antimicrobial substances needed for the manufacture of drugs for the treatment of many infectious diseases. Up until now, its antimicrobial activity is not well researched and its validity remains only vaguely defined.
Suppressor Mutations Suggest a Surface on PAT-4 (Integrin-linked Kinase) That Interacts with UNC-112 (Kindlin)*

Background: Interaction between PAT-4 (ILK) and UNC-112 (kindlin) is required for localization of each protein to integrin adhesions. Results: PAT-4 missense mutations were identified that restore binding of a mutant UNC-112 protein and its proper localization. Conclusion: Residues mutated in the suppressor mutants cluster in two regions on the surface of a homology model of PAT-4. Significance: An interaction surface between PAT-4 and UNC-112 is suggested. Caenorhabditis elegans striated muscle cells attach to basement membrane and transmit the force of muscle contraction through integrin adhesion complexes. The cytoplasmic tail of β-integrin (PAT-3) is associated with a conserved four-protein complex that includes UNC-112 (kindlin), PAT-4 (integrin-linked kinase), PAT-6 (α-parvin/actopaxin), and UNC-97 (PINCH). The proper localization of UNC-112 to muscle integrin adhesion sites requires PAT-4. A recent report (Qadota, H., Moerman, D. G., and Benian, G. M. (2012) A molecular mechanism for the requirement of PAT-4 (integrin-linked kinase (ILK)) for the localization of UNC-112 (kindlin) to integrin adhesion sites. J. Biol. Chem. 287, 28537–28551) suggests a possible molecular mechanism for this requirement: that UNC-112 exists in closed inactive and open active conformations, and conversion to the open active form is promoted by binding to PAT-4 (ILK). Previously, we also reported identification of a single missense mutation in UNC-112, D382V, which abolishes both binding to PAT-4 and normal localization to integrin adhesion sites in vivo. In this report, we describe isolation and characterization of PAT-4 missense mutations that permit binding with UNC-112 D382V and place nine affected residues on a homology model of PAT-4. These nine residues cluster in two regions on the surface of PAT-4, do not overlap the likely binding surface for PAT-6 (α-parvin), and therefore may reside along the interaction surface of PAT-4 for UNC-112 (kindlin). We also show that one of these PAT-4 mutations restores the ability of UNC-112 D382V to localize to integrin adhesions and participate in complex formation.
Knowledge and competence in temporomandibular disorders among Swedish general dental practitioners and dental hygienists

Abstract Objective: The aim of this study was to investigate knowledge and competence in temporomandibular disorders (TMD) among dentists and dental hygienists working in the public dental service (PDS) in Sweden. Materials and methods: The study population comprised all general dentists (n = 110) and dental hygienists (n = 80) working in the PDS in two Swedish counties: Kronoberg (K) and Blekinge (B). The participants filled out a questionnaire comprised of 15 questions. Results: The results of these questions are presented. The overall response rate for the general dentists was 87%, while the rate for the dental hygienists was 71%. Statistically significant differences between the general dentists in the two counties were found regarding the following: education in the field of TMD over the last 5 years (K: 37%, B: 73%), evaluation of occlusion when examining patients with suspected TMD (‘always’: K: 61%, B: 82%), and a desire for consultation of the OFP (orofacial pain)/TMD specialist by telephone (K: 71%, B: 44%). Regarding the dental hygienists, there was a statistically significant difference concerning the use of the treatment modality ‘reassurance’ (K: 41%, B: 7%). Conclusions: The majority of the dental care providers in both counties – irrespective of professional category – had a positive attitude towards patients with TMD. Knowledge and competence in the field are sparse and require postgraduate education. There is a great need of an OFP/TMD specialist for more complicated patients and a need to implement updated knowledge and competence in the PDS in these two counties.
The self-organization of starch on paper

The objective of this study was to clarify how modified starch polymers self-organize on the surface of paper. Understanding this phenomenon could enable tailoring of the surface of paper with small amounts of polymer, thereby controlling and adjusting its surface chemistry and absorption properties. Native potato starch without depolymerization was modified with either hydrophilic or hydrophobic side chains, which were either neutral or anionic. These modified starches were applied to the paper surface by means of spray sizing. Starch penetration into the paper structure was reduced due to the high molecular weight of the native potato starch (Mw ≈ 2*10 6 ). Repulsion forces between the side chains of the anionically modified starch affected polymer elongation, paper surface oriented conformation, and paper coverage. The anionic side chains of the starch also experience repulsion from the anionic carboxylate ions of the base paper, which causes the side chains to orient themselves away from the paper. This selforganization phenomenon is most pronounced with a hydrophilic base paper with a high anionic charge. Modifying the chemical properties of the side chains makes it possible to control the surface energy of the base paper using an extremely low amount of polymer.
Experiences From a Web- and App-Based Workplace Health Promotion Intervention Among Employees in the Social and Health Care Sector Based on Use-Data and Qualitative Interviews

Background An increasing number of Web- and app-based tools for health promotion are being developed at the moment. The ambition is generally to reach out to a larger part of the population and to help users improve their lifestyle and develop healthier habits, and thereby improve their health status. However, the positive effects are generally modest. To understand why the effects are modest, further investigation into the participants’ experiences and the social aspects of using Web- and app-based health promotion tools is needed. Objective The objectives of this study were to investigate the motivation behind taking part in and using a Web- and app-based health promotion tool (SoSu-life) at the workplace and to explore the participants’ experiences with using the tool. Methods Qualitative interviews with 26 participants who participated in a 38-week randomized controlled trial of a workplace Web- and app-based tool for health promotion were conducted. Data were supplemented with tracking the frequency of use. The basic features of the tool investigated in the trial were self-reporting of diet and exercise, personalized feedback, suggestions for activities and programs, practical tips and tricks, and a series of social features designed to support and build interactions among the participants at the workplace. Results The respondents reported typically one of the two reasons for signing up to participate in the study: either a personal wish to attain some health benefits or the more social reason that participants did not want to miss out on the social interaction with colleagues. Peer pressure from colleagues had made some participants to sign up even though they did not believe they had an unhealthy behavior. Of the total of 355 participants in the intervention group, 203 (57.2%) left the intervention before it ended. Of the remaining participants, most did not use the tool after the competition at the end of the initial 16-week period. The actual number of active users of the tool throughout the whole intervention period was low; however, the participants reported that lifestyle habits became a topic of conversation. Conclusions A tool that addresses group interactions at workplaces appears to initiate peer pressure, which helped recruitment for participation. However, active participation was low. A social change was indicated, allowing for more interaction among colleagues around healthy lifestyle issues. Future and more long-term studies are needed to determine whether such social changes could lead to sustained improvements of health.