Miracle-dz/UniFAR-FTUs huggingface dataset:
An Advanced Dual-Carrier-Based Multi-Optimized PWM Strategy of Three-Level Neutral-Point-Clamped Converters for More-Electric-Aircraft Applications

Since three-level neutral-point-clamped (3L-NPC) power generation units bring much competitiveness to the next-generation electric starter/generator (ESG) system for more-electric-aircraft (MEA) applications, the versatile multi-optimized pulse-width-modulation (PWM) becomes a key enabler to this technology. Regarding the mission profile of the state-of-art ESG, the operating points at the cruise feature a high modulation index and low power factor. This means that the neutral-point potential (NPP) fluctuation becomes severe. Besides, if switching states are not configured properly, not only could the lifetime of capacitors be threatened but also irreversible damage to bearing insulation occurs due to the common-mode voltage (CMV), followed by devastating effects on the reliability of other avionic facilities. Given the limitations of the 270VDC unipolar dc-bus structure, deep flux-weakening currents are constantly required for the high speed, resulting in more machine copper losses. To address these issues without any hardware-level efforts, an advanced PWM strategy with dual-carrier-based implementation is proposed in this article, which achieves boosted dc-link voltage utilization, CMV reduction and balanced NPP at the same time. Simulation results obtained from Simulink/PLECS and experimental results obtained from a 45 kW, 32 krpm ESG prototype system verify the effectiveness and feasibility of the proposed algorithm.
What is the Wind Stress Over the Tropical Pacific

NINO4 τx anomalies from FSU & NCEP, and NINO3 SSTAs. (a) Timeseries, with standard deviation σ and lag-1 autocorrelation φ1. The NCEP timeseries shows more pronounced westerly spikes than FSU, notably in 1982 and 1997. (b) Spectral density (blue), with the 0.95 quantile for red noise. The NCEP spectrum is more stationary in time than FSU, and exhibits a recent shift toward longer periods that is more consistent with the SSTA spectrum. (c) Average spectra for 1961–79 (green dashed) and 1980–99 (black), with a 90% interval for red noise. (d) Variance in the 0–1 yr (green dashed) and 1–8 yr (black) bands, with 90% intervals for red noise. 7. Local correlation of analyses
Adjuvant Lenvatinib Plus PD-1 Antibody for Hepatocellular Carcinoma with High Recurrence Risks After Hepatectomy: A Retrospective Landmark Analysis

Purpose To evaluate the efficacy and safety of lenvatinib plus programmed death-1 (PD-1) antibody as postoperative adjuvant therapy in patients with hepatocellular carcinoma (HCC) at high risks of recurrence. Patients and Methods A series of 137 patients with HCC at high risks of recurrence who underwent hepatectomy at our hospital between October 2019 and January 2022 were retrospectively analyzed. Recurrence-free survival (RFS), overall survival (OS), and treatment-related adverse events (TRAEs) were assessed. Landmark analysis was used to compare short- and long-term RFS. Univariable and multivariable analyses were used to identify prognostic factors, and subgroup analyses were performed according to high risks of recurrence. Results A total of 85 patients underwent hepatectomy alone and 52 patients received postoperative adjuvant therapy. Compared with the hepatectomy group (HG), RFS was significantly improved in the adjuvant therapy group (ATG) (P < 0.001), but OS was not (P = 0.098). Landmark analysis revealed that RFS within 6 months of the HG was significantly different from that of the ATG (P < 0.001) but not after 6 months (P = 0.486). Multivariable analysis showed that without adjuvant therapy, high Child-Pugh classification, high alpha-fetoprotein levels, microvascular invasion, and satellite lesions were independent risk factors for recurrence within 6 months after hepatectomy. Subgroup analysis revealed that patients with MVI significantly benefited from adjuvant therapy in RFS. But for OS, adjuvant therapy was only significantly effective in patients with single tumor. The most common treatment-related adverse events during adjuvant therapy were hypertension (36.5%), rash or itching (28.8%), diarrhea (23.1%), and fatigue (21.2%). Conclusion Postoperative adjuvant lenvatinib plus PD-1 antibody significantly improved RFS in patients with HCC at high risks of recurrence with acceptable safeties.
TAGAP expression influences CD4+ T cell differentiation, immune infiltration, and cytotoxicity in LUAD through the STAT pathway: implications for immunotherapy

Background T-cell Activation GTPase Activating Protein (TAGAP) plays a role in immune cell regulation. This study aimed to investigate TAGAP’s expression and its potential impact on CD4+ T cell function and prognosis in lung adenocarcinoma (LUAD). Methods We analyzed TAGAP expression and its correlation with immune infiltration and clinical data in LUAD patients using multiple datasets, including The Cancer Genome Atlas (TCGA-LUAD), Gene Expression Omnibus (GEO), and scRNA-seq datasets. In vitro and in vivo experiments were conducted to explore the role of TAGAP in CD4+ T cell function, chemotaxis, and cytotoxicity. Results TAGAP expression was significantly lower in LUAD tissues compared to normal tissues, and high TAGAP expression correlated with better prognosis in LUAD patients. TAGAP was positively correlated with immune/stromal/ESTIMATE scores and immune cell infiltration in LUAD. Single-cell RNA sequencing revealed that TAGAP was primarily distributed in CD4+/CD8+ T cells. In vitro experiments showed that TAGAP overexpression enhanced CD4+ T cell cytotoxicity, proliferation, and chemotaxis. Gene Set Enrichment Analysis (GSEA) indicated that TAGAP was enriched in the JAK-STAT signaling pathway. In vivo experiments in a xenograft tumor model demonstrated that TAGAP overexpression suppressed tumor growth and promoted CD4+ T cell cytotoxicity. Conclusions TAGAP influences CD4+ T cell differentiation and function in LUAD through the STAT pathway, promoting immune infiltration and cytotoxicity. This study provides a scientific basis for developing novel LUAD immunotherapy strategies and exploring new therapeutic targets.
The Effects of Emotional Labor on Work Strain and Nonwork Strain Among Dancers: A Person-Centered Approach

Introduction Emotional labor is an important research area, but four key gaps remain regarding outcomes of nonwork strains, explanatory frameworks beyond the conservation of resources theory, adoption of person-centered approaches, and subjects of performers. Methods By surveying 183 Chinese dance students, we employed cluster analysis to examine the adoption of emotional labor strategies (ie, surface acting, deep acting, and expression of naturally felt emotions) and to explore the outcomes on work strain (ie, emotional exhaustion and reduced flow experience) and nonwork strain (ie, depression and anxiety) with introducing the allostatic load theory as an analytical basis. Results Four types of emotional workers were identified, namely, flexible regulators (33.33%), authentic regulators (15.85%), display rules compliers (39.34%), and non-regulators (11.48%). Authentic regulators had the lowest emotional exhaustion. Non-regulators had the lowest flow. No differences emerged in depression or anxiety across clusters. Discussion Findings partially align with past research showing risks of surface acting in terms of emotional exhaustion. However, all three strategies enhanced flow states. Moreover, dancers’ work strains did not extend to psychological problems, unlike other professions. Possible explanations include training in emotional regulation and flow states in performing. Practical implications exist for training emotional regulation and fostering flow at work.
Effects of Annual Growth Conditions on Phenolic Compounds and Antioxidant Activity in the Roots of Eryngium montanum

Medicinal plants grown in natural settings are exposed to different adverse environmental conditions that determine their growth and development as well as the composition and concentration of secondary metabolites in their organs. The objective of this study was to evaluate the effects of environmental conditions associated with localities and annual growth cycles on the contents of phenolic compounds and flavonoids, antioxidant activity and potentially bioactive phenolic acids in the roots of Eryngium montanum, a medicinal species from temperate Mexico. The samples for composition analysis were collected using a bifactorial design: Factor A consisted of the localities (Morelos and La Unión de San Martin Huamelulpam, Mexico) and Factor B was represented by the annual growth cycle (2020 and 2021). In each sample, the contents of polyphenols and equivalent flavonoids of quercetin and catechin and antioxidant activity were evaluated using spectrophotometry. Subsequently, chlorogenic, caffeic and rosmarinic acids were identified and quantified using high-performance liquid chromatography with diode-array detection (HPLC-DAD). The annual growth conditions and, to a lesser extent, the locality of origin of the samples significantly influenced the contents of phenolic compounds and antioxidant activity. The environmental conditions that occurred in 2021 favored an increase in the contents of phenolic compounds compared to those in 2020, and the same pattern was observed for chlorogenic acid; however, for caffeic and rosmarinic acids, the opposite pattern was observed. The content of phenolic acids in the roots of E. montanum follows different and independent patterns between cycles based on the interaction between the locality of origin and annual growth cycle. This study quantifies the magnitude of the total environmental effect on the phenolic compound concentrations in E. montanum roots, which was measured via sampling during two annual growth cycles, where the sampling locations factor had little influence. The bioactive compounds identified in E. montanum roots have the potential for use as alternative medicines, as mentioned by different families from Oaxaca, Mexico.
The Mediating Effect of the Intention to Quit as the Impact of Locus of Control on Dysfunctional Audit Behavior

Auditing is an essential process in maintaining accountability and transparency within an organization. However, some dysfunctional audit behaviors can threaten audit integrity and cause significant losses to the company. This study aims to prove whether or not the intention to quit can mediate the indirect effect between locus of control on auditor acceptance of dysfunctional audit behavior, especially in all Public Accounting Firms in East Java Region. This is a quantitative causality research, and the data source in this study are generated from the primary data. The data are obtained from the respondents' answers to questionnaires given to all auditors who work at public accounting firms in East Java region. The 11 items-questionnaire was distributed via Google form. The results indicated that locus of control has a positive effect on auditors’ acceptance of dysfunctional audit behavior, intention to quit has a positive effect on auditors’ acceptance of dysfunctional audit behaviors, and locus of control has a positive effect on the intention to quit. Finally, the intention to quit is able to mediate the indirect effect of locus of control on auditors’ acceptance of dysfunctional audit behaviors.
Opportunities for cost-effective manufacturing of fully printed high performance displays enabled by vertical light-emitting transistor pixels

With the vertical organic light-emitting transistor (VOLET), we introduce a promising solution that could significantly benefit the manufacturing of displays, accelerating the wide adoption of flexible and printed electronics. The VOLET—like conventional, lateral channel, organic thin film transistors—is compatible with a variety of printing techniques as well as flexible substrates and low-temperature processing. In combination these devices will enable a more cost-effective approach to mass-production that can dramatically extend the market potential of active-matrix organic light-emitting diode (AMOLED) displays. In this paper we discuss the prospects that AMOLED presents for the future of the display market, with a focus on the innovative VOLET device architecture. We assess how the integration of this device into active-matrix displays can contribute to the long range sustained competitiveness of AMOLED technology. We review recent progress in mass production techniques for printed electronics, with a particular emphasis on large-scale carbon nanotube material deposition. Finally, we explore the prospects for fully printed active-matrix light-emitting displays, including a review of high-performance printed components whose integration could facilitate the mass production of low-cost, high-performance, VOLET based AMOLEDs.
3.1 Global High Resolution Analyses and Forecasts at the Mesoscale

Abstract : The feasibility of global ocean weather prediction was just emerging as GODAE began in 1997. Ocean weather includes phenomena such as meandering currents and fronts, eddies, the surface mixed layer and sea surface temperature (SST), equatorial and coastally trapped waves, upwelling of cold water, and Rossby waves, all influencing ocean variables such as temperature (T), salinity (S), currents, and sea surface height (SSH). Adequate real-time data input, computing power, numerical ocean models, data assimilation capabilities, atmospheric forcing, and bathymetric/boundary constraints are essential to make such prediction possible. The key observing systems and real-time data inputs are SSH from satellite altimetry, satellite and in situ SST, T or T&S profiles (e.g. Argo, TAO, PIRATA, BTs), and atmospheric forcing. The ocean models dynamically interpolate the data in conjunction with the data assimilation, convert atmospheric forcing into oceanic responses, and forecast the ocean weather, applying the bathymetric/boundary constraints in the process. The results are substantially influenced by ocean model simulation skill and it is advantageous to use an ocean model that is eddy-resolving (typically < 8 km grid increments), not just eddy-permitting. Since the most abundant ocean observations are satellite surface data and subsurface data are very sparse in relation to the space scales of the mesoscale ocean features that dominate the ocean interior, downward projection of surface data is a key challenge in ocean data assimilation. The need for accurate prediction of ocean features that are inadequately observed, such as the mixed layer depth, places a major burden on the ocean model, the data assimilation, and the atmospheric forcing.
Experimental study on effect of temperature and moisture on piezoresistive effect of carbon nanotube concrete

Carbon nanotube (CNT) reinforced cement based composite materials can be used as self-sensing sensors for intelligent monitoring of concrete structures. In practical engineering, concrete structures are affected and restricted by various environmental factors. Therefore, this paper conducted experimental research on the influencing factors of the piezoresistive effect of CNT concrete. The main influencing factors selected include CNT concentration (0 wt.%–0.5 wt.%), moisture content (immersion time of 0 min–120 min), and temperature (20 °C–60 °C). The experimental results show that the specimen with a CNT concentration of 0.5 wt. % has a higher stress sensitivity (SES), and the change in resistivity shows good stability and repeatability under cyclic stress. The resistivity decreases with prolongation of immersion time, and the SES increases first and then decreases, reaching a peak at 30 min of immersion. When the temperature increases from 20 °C to 60 °C, the resistivity decreases. The influence of temperature on dry and wet specimens is different. In the moisture state, the fraction change in resistivity and SES always decreased. In the dry state, as the temperature increases, the SES first increases and then decreases, with the maximum value occurring at 30 °C.
Characterization of flux pump-charging of high-temperature superconducting coils using coupled numerical models

Flux pumps provide a promising solution for contactless charging of high-temperature superconducting (HTS) coils, eliminating the need for bulk current leads and reducing the heat burden for the cryogenic system. Characterizing the nonlinear effects of an HTS coil charged by a flux pump and understanding the dynamics of the charging process is essential for promoting the practical application of flux pumps. Numerical models provide a fast and cost-effective way of achieving this. In this study, we propose a methodology for coupling HTS coil and flux pump models using an electrical circuit, resulting in reduced computation costs. We validate the effectiveness of our approach against the experimental results of an HTS coil charged by a dynamo-type flux pump. Specifically, we obtain the voltage produced by the HTS dynamo using a 3D model based on the minimum electromagnetic entropy production method and apply this voltage to the load HTS coil using a T−A formulation finite-element method model coupled via an electrical circuit. The simulated charging current shows good agreement with experimental observations, validating our modeling strategy. The results demonstrate that the flux flow state in the HTS coil is the primary factor limiting the charging performance of the HTS dynamo as the charging current approaches the coil’s critical current. Furthermore, based on the simulation, we demonstrate that, when using flux pumps, it is advisable to leave a margin between the operating current and the critical current of the coil. Overall, our approach has the potential to be applied to HTS coils charged by any device.
Asymptomatic Propylthiouracil Induced Agranulocytosis in a Patient with Toxic Nodular Goiter: A Rare Case Report

Background Agranulocytosis is a rare but fatal side effect of antithyroid drugs (ATDs) with incidence reported at 0.1%‐1%. Agranulocytosis is defined as a granulocyte count <500 cells/μL following the use of ATDs and is an absolute contraindication to the use of these drugs; in this case, radioactive iodine (RAI) or surgery are therapeutic options. Case Presentation A 28-year-old female patient was on follow-up at our clinic after she presented with anterior neck swelling of 4 years. The patient was started on propylthiouracil (PTU) and propranolol based on clinical symptoms of hyperthyroidism and low thyroid stimulating hormone (TSH) levels. After taking the ATDs for 7 months, she came to the clinic for her regular follow-up. At this point, she was declared euthyroid and booked for surgery. Investigations were sent and the complete blood count (CBC) result showed leucopenia with agranulocytosis, even though she was completely asymptomatic. The offending ATD was immediately discontinued. The patient was kept inpatient for monitoring, and lugol’s iodine and propranolol were initiated. Eight days after discontinuing the ATD, the CBC profile was determined once again, showing normalized total leukocyte, as well as, absolute neutrophil count. Eventually, the multinodular goiter (MNG) was managed with subtotal thyroidectomy. Conclusion Despite the fact that agranulocytosis is an extremely rare side effect of ATDs, most often PTU; it is a potentially fatal complication when it occurs. Patient education at the time of prescription should not be overlooked, and systematic programs should be put in place. The baseline granulocyte count should be determined and monitored on a regular basis.
Insights into the Early Transgressive History of Lake Bonneville from Stratigraphic Investigation of Pilot Valley Playa, UT/NV, USA

Insights into the Early Transgressive History of Lake Bonneville from Stratigraphic Investigation of Pilot Valley Playa, UT/NV, USA. Kevin A. Rey Department of Geological Sciences, BYU Master of Science Multiple shallow sediment cores were obtained from Pilot Valley playa, a sub-basin located in the northwestern Bonneville basin. Analysis of stratigraphy, ostracodes, mineralogy, chemistry, total inorganic carbon (TIC), total organic carbon (TOC), and stable isotopes were performed to better place these sediments into proper context with respect to the Lake Bonneville cycle. Results showed Pilot Valley playa contains a nearly full sequence of Lake Bonneville deep-water marl in addition to sediments deposited before and after the Lake Bonneville cycle. Within the marl is a sequence of organic rich algal laminated marl correlated with the Stansbury oscillation. Four C ages ranging from ~22.4 k C years to ~15.8 k C years from preserved algae filaments in this sequence place it well within the time frame of the Stansbury oscillation. Oolitic sand found below this sequence indicates the existence of a shallow (<~5 m), saline lake in Pilot Valley prior to the transgression of Lake Bonneville. Analysis of sediments deposited during the late regressive phase of Lake Bonneville indicates the lake may have fallen to levels below that of Pilot Valley prior to transgressing to the Gilbert level.
Prevalence and Modifiable Factors for Holistic Non-Adherence in Renal Transplant Patients: A Cross-Sectional Study

Introduction In renal transplant recipients, compliance with medical therapy is vital. Non-adherence is considered a risk factor for worst outcomes in kidney recipients, with attributed outcomes of 64% for graft loss and 80% for late acute rejection. Most literature defines adherence as self-based immunosuppression compliance but does not consider other relevant factors such as consult and procedure compliance. Therefore, this study aims to describe adherence prevalence in kidney transplant recipients and the factors related to non-adherence. Methods This cross-sectional study included 1030 renal transplant patients followed by Colombiana de Trasplantes between January 2019 and July 2021. Sociodemographic and clinical variables were obtained based on clinical records. The mental-health group diagnosed holistic adherence in a semi-structured interview. The diagnosis considered medication intake failure, frequency and number of failures to medical controls or other procedures, suspicious non-adherence behaviors, and serum levels of immunosuppressants. A bivariate followed a descriptive analysis, and a forward logistic regression was performed for non-adherence. Results Patients had a median of 47 years, and 58.1% were male. Non-adherence was presented in 30.7% of patients. The non-adherence patients were younger, with a higher prevalence of males, single, divided transplant care, had a longer time after transplantation, psychopathological diagnosis, and more reinforcement education by only nursing. Older age and multidisciplinary reinforcement education were protective factors. On the other hand, poor social support, psychopathology diagnosis, and longer time after transplant presented as non-adherence risk factors. Conclusion Holistic non-adherence was diagnosed in approximately one-third of renal transplant recipients. Its definition included more than just medication non-compliance and could identify more non-adherent patients. Notably, there is a need to consider the related factors in the health follow-up and encourage future research in modifiable factor interventions aiming to increase adherence and achieve better outcomes for renal transplant patients.
Towards sustainable rural communities

The future of rural communities relies on managing knowledge trasnfer and sharing in order to advance towards sustainable rural development. Investing in knowledge sources and management helps rural organisations to drive social growth, fostering cohesive and socially open rural communities. Rural communities may address a knowledge-driven pathway for sustainable rural development. Rural actors and stakeholders contribute to shaping wealthy rural communities by employing the potential of knowledge management, transfer and sharing. Regulatory frameworks support collaboration within rural communities that benefit of knowledge management issues and practices.