Miracle-dz/UniFAR-FTUs huggingface dataset:
Carbonaceous Materials in the Fault Zone of the Longmenshan Fault Belt: 2. Characterization of Fault Gouge from Deep Drilling and Implications for Fault Maturity

In recent works on the determination of graphitization of carbonaceous materials (CM) within the principal slip zone (PSZ) of the Longmenshan fault (China), we demonstrated that the formation of graphite, resulted from strain and frictional heating, could be evidence of past seismic slip. Here we utilize Raman Spectroscopy of CM (RSCM) on the CM-bearing gouges in the fault zone of the Longmenshan fault belt, at the borehole depth of 760 m (FZ760) from the Wenchuan earthquake Fault Scientific Drilling project-1 (WFSD-1), to quantitatively characterize CM and further retrieve ancient fault deformation information in the active fault. RSCM shows that graphitization of CM is intense in the fault core with respect to the damage zone, with the graphitized carbon resembling those observed on experimentally formed graphite that was frictionally generated. Importantly, compared to the recognized active fault zone of the Longmenshan fault, the RSCM of measured CM-rich gouge shows a higher degree of graphitization, likely derived from high-temperature-perturbation faulting events. It implies that FZ760 accommodated numerous single-event displacement and/or at higher normal stresses and/or in the absence of pore fluid and/or along a more localized slip surface(s). Because graphite is a well-known lubricant, we surmise that the presence of the higher degree graphitized CM within FZ760 will reduce the fault strength and inefficiently accumulate tectonic stress during the seismic cycle at the current depth, and further infer a plausible mechanism for fault propagation at the borehole depth of 590 m during the Mw 7.9 Wenchuan earthquake.
How do we assess batch‐to‐batch consistency between extracellular vesicle products?

Extracellular vesicles (EVs) have gained interest in the field of regenerative and transfusion medicine. Specifically, current Good Manufacturing Practice (cGMP)‐grade EVs produced by mesenchymal stromal cells (MSCs) are an intriguing option for cell‐free therapeutics. With the development of cGMP‐grade EV products, a simple and reliable method for batch‐to‐batch consistency is needed.
Study protocol for a Prospective, Randomized Controlled trial of stEnt graft and Drug-coated bAlloon Treatment for cephalic arch stenORsis in dysfunctional arteio-venous fistulas (PREDATOR).

BACKGROUND Treatment of cephalic arch stenosis (CAS) is associated with high risk of failure and complications. Although stent-graft (SG) placement has improved patency rates, stent edge restenosis has been raised as a potential limiting factor for SG usage in CAS. This study aims to evaluate the safety and efficacy of combining stent graft placement with paclitaxel-coated balloon (PCB) angioplasty versus PCB alone in the treatment of CAS. METHODS This is an investigator-initiated, prospective, international, multicenter, open-label, randomized control clinical trial that plans to recruit 80 patients, who require fistuloplasty from dysfunctional arteriovenous fistula (AVF) from CAS. Eligible participants are randomly assigned to receive treatment with SG and PCB or PCB alone in a 1:1 ratio post-angioplasty (n = 40 in each arm). Randomization is stratified by de novo or recurrent lesion, and the participants are followed up for 1 year. The primary endpoints of the study are target lesion primary patency (TLPP) and access circuit primary patency (ACPP) rates at 6-months. The secondary endpoints are TLPP and ACPP at 3- and 12-month; target lesion and access circuit assisted primary and secondary patency rates at 3, 6, and 12-months and the total number of interventions; complication rate; and cost-effectiveness. DISCUSSION This study will evaluate the clinical efficacy and safety of combination SG and PCB implantation compared to PCB alone in the treatment of CAS for hemodialysis patients.
Paired state in an integrable spin-1 boson model

An exactly solvable model describing the low-density limit of the spin-1 bosons in a one-dimensional optical lattice is proposed. The exact Bethe ansatz solution shows that the low-energy physics of this system is described by a quantum liquid of spin singlet bound pairs. Motivated by the exact results, a mean-field approach to the corresponding three-dimensional system is carried out. Condensation of singlet pairs and coexistence with ordinary Bose-Einstein condensation are predicted.
Power motivation arousal promotes prosocial behavior in the dictator game depending on social presence

Despite the popular notion that power motivations are associated with aggression and antisocial behavior, this study tested the hypothesis that activating power motivations can promote prosocial behavior. Because previous research has shown that public prosocial behavior is associate with reputation and status, this study examined how making prosocial decisions publicly or privately moderates the relationship between power motivations and prosocial behavior. One hundred and forty participants were randomly assigned to watch 20 min of either The Experiment (power motivation arousal) or a documentary called Beautiful China (control condition). A modified version of the dictator game was used to measure prosocial behavior. Participants were instructed to allocate an amount of money between themselves and a stranger girl in need, in the presence of the experimenter (the experimenter registers donation amount) or in the absence of the experimenter (the donation was put in a closed envelope). The results showed that individuals in the power motivation arousal group increased their help when their reputation was under scrutiny due to the experimenter’s presence. In the private condition (experimenter is absent), power motivation is not related to prosocial behavior. The contrasting behavioral reactions resulting from the presence or absence of the experimenter are discussed in terms of reputation gain and competitive altruism.
In silico designed microtubule-stabilizer drugs against tauopathy in Alzheimer’s disease

Abstract Microtubules are the main building blocks of the cytoskeleton that maintain the shape of the cell. Microtubule-associated proteins, such as Tau protein, facilitate their plasticity in cells. Highly phosphorylated Tau has weak affinity to microtubule and, hence, high probability of aggregation into neurofibrillary tangles (tauopathy). Alzheimer’s disease evolves when Tau proteins are abnormally phosphorylated. To prevent tauopathy in Alzheimer’s disease, we designed drugs de novo targeting them in silico to the phosphorylated Tau-microtubule complexes. Our molecular docking (AutoDock, MOE, GOLD) and molecular dynamics (GROMACS, 2019.6) simulation results revealed compound 23 (C12H28N4O5) as a potential drug candidate, since it can bind (-11.1 kcal/mol by AutoDock) and fix not only phosphorylated Tau on the surface of microtubules, but also prevent their aggregation into bundles. In addition, compound 23 has shown its ability to de-bundle already grouped phosphorylated peptides into single pieces. Communicated by Ramaswamy H. Sarma
Neutrino Factories and the "Magic" Baseline

We show that for a neutrino factory baseline of $L\ensuremath{\sim}7300\char21{}7600\mathrm{km}$ a ``clean'' measurement of ${\mathrm{sin}}^{2}2{\ensuremath{\theta}}_{13}$ becomes possible, which is almost unaffected by parameter degeneracies. We call this baseline the ``magic'' baseline, because its length depends only on the matter density profile. For a complete analysis, we demonstrate that the combination of the magic baseline with a baseline of 3 000 km is the ideal solution to perform equally well for ${\mathrm{sin}}^{2}2{\ensuremath{\theta}}_{13},$ the sign of $\ensuremath{\Delta}{m}_{31}^{2},$ and CP violation sensitivities. In particular, this combination can very successfully resolve parameter degeneracies even below ${\mathrm{sin}}^{2}2{\ensuremath{\theta}}_{13}l{10}^{\ensuremath{-}4}. $
Metabolomic disorders: confirmed presence of potentially treatable abnormalities in patients with treatment refractory depression and suicidal behavior

Abstract Background Refractory depression is a devastating condition with significant morbidity, mortality, and societal cost. Approximately 15% of patients with major depressive disorder are refractory to currently available treatments. We hypothesized metabolic abnormalities contributing to treatment refractory depression are associated with distinct findings identifiable in the cerebrospinal fluid (CSF). Our hypothesis was confirmed by a previous small case-controlled study. Here we present a second, larger replication study. Methods We conducted a case-controlled, targeted, metabolomic evaluation of 141 adolescent and adult patients with well-characterized history of depression refractory to three maximum-dose, adequate-duration medication treatments, and 36 healthy controls. Plasma, urine, and CSF metabolic profiling were performed by coupled gas chromatography/mass spectrometry, and high-performance liquid chromatography, electrospray ionization, tandem mass spectrometry. Results Abnormalities were identified in 67 of 141 treatment refractory depression participants. The CSF abnormalities included: low cerebral folate (n = 20), low tetrahydrobiopterin intermediates (n = 11), and borderline low-tetrahydrobiopterin intermediates (n = 20). Serum abnormalities included abnormal acylcarnitine profile (n = 12) and abnormal serum amino acids (n = 20). Eighteen patients presented with two or more abnormal metabolic findings. Sixteen patients with cerebral folate deficiency and seven with low tetrahydrobiopterin intermediates in CSF showed improvement in depression symptom inventories after treatment with folinic acid and sapropterin, respectively. No healthy controls had a metabolite abnormality. Conclusions Examination of metabolic disorders in treatment refractory depression identified an unexpectedly large proportion of patients with potentially treatable abnormalities. The etiology of these abnormalities and their potential roles in pathogenesis remain to be determined.
Viruses in sanctuary chimpanzees across Africa

Infectious disease is a major concern for both wild and captive primate populations. Primate sanctuaries in Africa provide critical protection to thousands of wild‐born, orphan primates confiscated from the bushmeat and pet trades. However, uncertainty about the infectious agents these individuals potentially harbor has important implications for their individual care and long‐term conservation strategies. We used metagenomic next‐generation sequencing to identify viruses in blood samples from chimpanzees (Pan troglodytes) in three sanctuaries in West, Central, and East Africa. Our goal was to evaluate whether viruses of human origin or other “atypical” or unknown viruses might infect these chimpanzees. We identified viruses from eight families: Anelloviridae, Flaviviridae, Genomoviridae, Hepadnaviridae, Parvoviridae, Picobirnaviridae, Picornaviridae, and Rhabdoviridae. The majority (15/26) of viruses identified were members of the family Anelloviridae and represent the genera Alphatorquevirus (torque teno viruses) and Betatorquevirus (torque teno mini viruses), which are common in chimpanzees and apathogenic. Of the remaining 11 viruses, 9 were typical constituents of the chimpanzee virome that have been identified in previous studies and are also thought to be apathogenic. One virus, a novel tibrovirus (Rhabdoviridae: Tibrovirus) is related to Bas‐Congo virus, which was originally thought to be a human pathogen but is currently thought to be apathogenic, incidental, and vector‐borne. The only virus associated with disease was rhinovirus C (Picornaviridae: Enterovirus) infecting one chimpanzee subsequent to an outbreak of respiratory illness at that sanctuary. Our results suggest that the blood‐borne virome of African sanctuary chimpanzees does not differ appreciably from that of their wild counterparts, and that persistent infection with exogenous viruses may be less common than often assumed.
The impact of intrathecal baclofen on the ability to walk: A systematic review

Objective Intrathecal baclofen (ITB) is an effective treatment for lower limb spasticity. In ambulatory patients with spasticity, there is a justifiable concern that ITB treatment may compromise ambulatory function by reducing the heightened muscle tone, thereby unmasking underlying muscle weakness. ITB is hence offered with reservation in ambulant patients. In this article, we review the literature surrounding the effect of ITB therapy on ambulatory function in patients with concurrent spasticity and discuss the key findings. Data sources A literature search of ProQuest Medline and EBSCO CINAHL databases was performed. Review method Inclusion criteria included (a) studies reporting the effect of ITB in adult ambulatory patients; (b) studies with an intervention of screening test trial via either bolus injections or continuous infusion tests; and (c) studies with an intervention of ITB pump implantation. Seventeen eligible studies were identified and two authors independently assessed the study quality using the risk of bias in nonrandomised studies of interventions tool (ROBINS-I). Results Seventeen studies were included, with a total of 534 participants. Most of the patients remain ambulatory after ITB treatment, accompanied by improvements in gait speed and reduction in spasticity. Conclusion ITB therapy when administered in carefully selected ambulatory patients with spasticity is not associated with loss of ambulatory function.
Progression of microstructural deterioration in load-bearing immobilization osteopenia

Purpose Immobilization osteopenia is a major healthcare problem in clinical and social medicine. However, the mechanisms underlying this bone pathology caused by immobilization under load-bearing conditions are not yet fully understood. This study aimed to evaluate sequential changes to the three-dimensional microstructure of bone in load-bearing immobilization osteopenia using a fixed-limb rat model. Materials and method Eight-week-old specific-pathogen-free male Wistar rats were divided into an immobilized group and a control group (n = 60 each). Hind limbs in the immobilized group were fixed using orthopedic casts with fixation periods of 1, 2, 4, 8, and 12 weeks. Feeding and weight-bearing were freely permitted. Length of the right femur was measured after each fixation period and bone microstructure was analyzed by micro-computed tomography. The architectural parameters of cortical and cancellous bone were analyzed statistically. Results Femoral length was significantly shorter in the immobilized group than in the control group after 2 weeks. Total area and marrow area were significantly lower in the immobilized group than in the control group from 1 to 12 weeks. Cortical bone area, cortical thickness, and polar moment of inertia decreased significantly after 2 weeks. Some cancellous bone parameters showed osteoporotic changes at 2 weeks after immobilization and the gap with the control group widened as the fixation period extended (P < 0.05). Conclusion The present results indicate that load-bearing immobilization triggers early deterioration of microstructure in both cortical and cancellous bone after 2 weeks.
Spectroscopy of the double quasars Q1343+266A, B: A new determination of the size of Lyman-alpha forest absorbers

We have obtained spectroscopy of Q 1343+266 AB, a pair of quasars at redshift z = 2.03 with a projected separation of 9.5 arcseconds. This system is well-suited for probing the Ly-alpha forest, since the two component spectra show several Ly-alpha lines in common and several others not. Using Bayesian statistics, under the idealization of uniform-radius spherical absorbers, we find that the Ly-alpha cloud radius at $z \approx 1.8$ lies in the range $40\hkpc < R < 280 \hkpc$ with $98\%$ confidence in a $(\Omega_o, \Lambda_o) = (1, 0)$ model universe, where $h =(H_o / 100 km s^{-1} Mpc^{-1})$. The median value of R is 90 h^-1 kpc. \ These numbers scale up by a factor 1.44 for $(\Omega_o, \Lambda_o) =(0.1, 0)$; and by a factor 1.85 for (0.1, 0.9). Pressure-confined and freely-expanding Ly-alpha cloud models in which the absorbers formed in a significantly more compressed state at $z \gg 2$ are contradicted by these new data, as are models involving stably-confined gas concentrations in photoionization equilibrium within minihalos of cold dark matter. The comoving density of Ly-alpha forest objects at $z\sim 2$ is $\sim 0.3 h (R/100 kpc)^{-2} Mpc^{-3}$ in a (1,0) model universe. This suggests a possible identification of Ly-alpha clouds with the unvirialized, collapsing progenitors of the faint, blue galaxies at $z\sim 1$.
X-ray deficiency on strongly accreting T Tauri stars. Comparing Orion with Taurus

Depending on whether a T Tauri star accretes material from its circumstellar disk or not, different X-ray emission properties can be found. The accretion shocks produce cool heating of the plasma, contributing to the soft X-ray emission from the star. Using X-ray data from the Chandra Orion Ultra-deep Project and accretion rates that were obtained with the Hubble Space Telescope/WFPC2 photometric measurements in the Orion Nebula Cluster, we studied the relation between the accretion processes and the X-ray emissions of a coherent sample of T Tauri sources in the region. We performed regression and correlation analyses of our sample of T Tauri stars between the X-ray parameters, stellar properties, and the accretion measurements. We find that a clear anti-correlation is present between the residual X-ray luminosity and the accretion rates in our samples in Orion that is consistent with that found on the XMM-Newton Extended Survey of the Taurus molecular cloud (XEST) study. We provide a catalog with X-ray luminosities (corrected from distance) and accretion measurements of an Orion Nebula Cluster (ONC) T Tauri stars sample. Although Orion and Taurus display strong differences in their properties (total gas and dust mass, star density, strong irradiation from massive stars), we find that a similar relation between the residual X-ray emission and accretion rate is present in the Taurus molecular cloud and in the accreting samples from the Orion Nebula Cluster. The spread in the data suggests dependencies of the accretion rates and the X-ray luminosities other than the stellar mass, but the similarity between Orion and Taurus hints at the environment not being one of them. The anti-correlation between the residual X-ray luminosity and mass accretion rate is inherent to the T Tauri stars in general, independent of their birthplace and environment, and intrinsic to early stellar evolution.
Fortification of Pasta with White Button Mushroom: Functional and Rheological Properties

Macaroni (pasta)—a popular extruded product prepared using durum wheat semolina is rich in complex carbohydrate, vitamin-B but deficient in proteins especially lysine and threonine leading to low biological value of the product. The present study was conducted to prepare a nutritionally enriched macaroni by supplementing semolina with white button mushroom. The fresh mushrooms are a rich source of proteins having most of the essential amino acids in good proportions, thus, can be a better option for nutritional enrichment of pasta with 10 to 30% supplementation. The mushroom fortified pasta showed better antioxidant activity of 11.14 percent as compared to 5.61% in control with phenol contents ranging from 0.559 to 0.660% with increased mushroom fortification. A gradual increase in moisture content, carbohydrates was also noticed with decreased crude fibre, crude protein, and fat as well. The SEM study and rheological properties showed the clear picture of protein network, a smooth outer surface, and significant increase in chewiness and springiness that resulted in a desirable mouthfeel during eating. Therefore, on the basis of sensory and rheological properties of mushroom supplemented pasta, the ratio of 80:20 was found to be the best and thus optimized for development of nutritionally enriched macaroni.
Multi-Field Inflation on the Landscape

We examine a wide class of multi-field inflationary models based on fields that decay or stabilize during inflation in a staggered fashion. The fields driving assisted inflation are on flat, short stretches, before they encounter a sharp drop; whenever a field encounters such a drop due to its slow roll evolution, its energy is transferred to other degrees of freedom, i.e. radiation. The rate at which fields decay is determined dynamically and it is not a free parameter in this class of models. To compute observables, we generalize the analytic framework of staggered inflation, allowing for more general initial conditions and varying potentials. By searching for generic situations arising on the landscape, we arrive at a setup involving linear or hilltop potentials and evenly spread out initial field values. This scenario is not more fine tuned than large-field models, despite the fact that many more degrees of freedom are involved. Further, the η-problem can be alleviated. The additional decrease of the potential energy caused by the decay of fields provides leading order contribution to observables, such as the scalar and tensor spectral index or the tensor to scalar ratio, for which we derive general expressions. We compare the predictions with WMAP5 constraints and find that hilltop potentials are borderline ruled out at the 2σ-level, while linear potentials are in excellent agreement with observations. We further comment on additional sources of gravitational waves and non-Gaussianities that could serve as a smoking gun for staggered inflation.
Strong Lensing Probability for Testing TeVeS Theory

We calculate the strong lensing probability as a function of the image separation Δθ in TeVeS (tensor-vector-scalar) cosmology, which is a relativistic version of MOND (MOdified Newtonian Dynamics). The lens, often an elliptical galaxy, is modeled by the Hernquist profile. We assume a flat cosmology with Ωb = 1 - ΩΛ = 0.04 and the simplest interpolating function μ(x) = min(1, x). For comparison, we recalculated the probabilities for lenses by singular isothermal sphere (SIS) galaxy halos in LCDM with a Schechter fit velocity function. The amplification bias is calculated based on the magnification of the second bright image rather than on the total of the two brighter images. Our calculations show that the Hernquist model predicts insufficient but acceptable probabilities in flat TeVeS cosmology compared with the results of the well-defined combined sample of the Cosmic Lens All-Sky Survey (CLASS) and the Jodrell Bank/Very Large Array Astrometric Survey (JVAS); at the same time, it predicts higher probabilities than the SIS model in LCDM at small image separations.