Miracle-dz/UniFAR-FTUs huggingface dataset:
Subcutaneous infusion of high-dose benzathine penicillin G is safe, tolerable, and suitable for less-frequent dosing for rheumatic heart disease secondary prophylaxis: a phase 1 open-label population pharmacokinetic study

ABSTRACT Since 1955, the recommended strategy for rheumatic heart disease (RHD) secondary prophylaxis has been benzathine penicillin G [BPG; 1.2 MU (900 mg)] injections administered intramuscularly every 4 weeks. Due to dosing frequency, pain, and programmatic challenges, adherence is suboptimal. It has previously been demonstrated that BPG delivered subcutaneously at a standard dose is safe and tolerable and has favorable pharmacokinetics, setting the scene for improved regimens with less frequent administration. The safety, tolerability, and pharmacokinetics of subcutaneous infusions of high-dose BPG were assessed in 24 healthy adult volunteers assigned to receive either 3.6, 7.2, or 10.8 MU (three, six, and nine times the standard dose, respectively) as a single subcutaneous infusion. The delivery of the BPG to the subcutaneous tissue was confirmed with ultrasonography. Safety assessments, pain scores, and penicillin concentrations were measured for 16 weeks post-dose. Subcutaneous infusion of penicillin (SCIP) was generally well tolerated with all participants experiencing transient, mild infusion-site reactions. Prolonged elevated penicillin concentrations were described using a combined zero-order (44 days) and first-order (t1/2 = 12 days) absorption pharmacokinetic model. In simulations, time above the conventionally accepted target concentration of 20 ng/mL (0.02 µg/mL) was 57 days for 10.8 MU delivered by subcutaneous infusion every 13 weeks compared with 9 days of every 4-weekly dosing interval for the standard 1.2 MU intramuscular dose (i.e., 63% and 32% of the dosing interval, respectively). High-dose SCIP (BPG) is safe, has acceptable tolerability, and may be suitable for up to 3 monthly dosing intervals for secondary prophylaxis of RHD.
FFT-LB Modeling of Thermal Liquid-Vapor System

我们在场为热液体蒸汽的一个改进格子 Boltzmann (磅) 模型系统。 在新模型，窗口的快 Fourier 变换(WFFT ) 和它的逆被用来计算传送对流术语和 LB 方程的外部力量术语。 由采用 WFFT 计划，当时，吉布斯摆动能在 unsmooth 区域有效地被抑制高决定特征光谱方法能在光滑的区域被保留。 作为结果，空间 discretization 错误戏剧性地被减少，全部的精力的保存更好被保存，并且液体蒸汽接口附近的假速度显著地被减少。 和 WFFT 途径的低复杂性，高分辨率为在多相的流动的领域里学习问题的一个宽班赋予建议方法以可观的潜力。
Seismic damage analysis of a concrete gravity dam based on energy dissipation

Nonlinear seismic analysis of a concrete gravity dam was performed based on the plastic damage theory.Its hysteretic feature,energy dissipation ability,failure mechanism and characteristics were studied.A seismic damage assessment model considering damage energy dissipation was developed for describing the damage level of the dam under strong earthquakes.The results showed that the damage of the upper part of the dam is the main damage of the structure;the vibration energy and the earthquake responses of the structure are reduced effectively by the structural damping;little amount of the seismic energy is dissipated by concrete damage and plastic dissipation.The seismic damage assessment model could quantitatively evaluate the damage level of gravity dams under strong earthquake.
Precision Analysis of BeiDou Range Measurement Signals

A code-minus-phase combination(CC) and multipath(MP) GPS and BeiDou range measurements analysis approach is demonstrated,and the qualitative results of single frequency GPS and BeiDou measurement signals are presented;the performances of CC ambiguity resolution with single frequency data is discussed lastly.The results show that: measurement signals of geostationary Earth orbit(GEO) satellite show a higher precision than Inclined geosynchronous satellite orbit(IGSO) satellite;the multipath effects of two kinds of measurement signals exist in long-term and short-term trend.When a long period is utilized,such as 600 s,the success rate of CC ambiguity resolution can reach over 90% in GPS L1/L2 and BeiDou B1/B2 frequency,however,when short period is utilized,such as 120 s,owing to the stronger multipath effects,the success rate of BeiDou IGSO satellite is the lowest,no more than 50%.
Food Application of Orange Seed Powder through Incorporation in Wheat Flour to Boost Vitamin and Mineral Profiles of Formulated Biscuits

The significance of conducting research for its application has been noted as a result of the rising global food production and waste generation. As a result, there is increasing interest in fruits and vegetable seeds that contain bioactive chemicals, such as those that are obtained from orange seeds. In the current work, orange seed powder replaced wheat flour at 0, 2.5, 5, 7.5, and 10% levels, to observe changes in physicochemical features of developed biscuits. Proximate analysis of orange seed powder and wheat flour revealed that orange seed powder has high fat, fiber, protein, and ash contents as compared to wheat flour, whereas moisture contents in wheat flour were high. In developed biscuits, the highest values (percentage) of ash (9.68 ± 0.04), fiber (6.79 ± 0.12), protein (10.42 ± 0.25), and fat (36.90 ± 0.55) were found in biscuits developed with 10% orange seed powder. Orange seed powder was a comparatively good source of both macro and micro minerals, as compared to wheat flour. High contents of selenium (5.32 ± 0.03), iron (2.12 ± 0.05), zinc (3.88 ± 0.12), and manganese (2.25 ± 0.04) mg/100 g, present in orange seed powder, were the prominent findings of this research work, as wheat flours were observed to be deficient in these trace minerals. Contents of calcium, magnesium, potassium, zinc, manganese, zinc, and selenium in control biscuits were found 20.51 ± 0.08, 17.29 ± 0.04, 46.12 ± 0.05, 1.06 ± 0.01, 1.97 ± 0.01, 0.12 ± 0.01, and 0.11 ± 0.01 mg/100 g, respectively, and replacement of wheat flour with 10% orange seed powder increased values of these minerals to 103.90 ± 0.35, 44.35 ± 0.50, 71.29 ± 0.32, 2.59 ± 0.4, 2.75 ± 0.02, 1.31 ± 0.01, and 2.02 ± 0.05 mg/100 g, respectively. Vitamins E and K, which were not detected in wheat flour, were present in orange powder in high amount, whereas B group vitamins, which were also present in wheat flour, were observed in significantly high quantities in orange seed powder. Increment in vitamin A, D, E, K, and B complexes was significant as a result of orange seed powder supplementation, except for vitamins B1 and B2, which were slightly decreased. Sensory evaluation revealed that a 5% replacement of orange seed powder provided good quality biscuits with acceptable colour, flavor, taste, texture, and overall acceptability. Orange seed powder could prove an important ingredient in the baking industry with the potential of promoting the nutritional value of foods.
Symbiotic Functioning and Photosynthetic Rates Induced by Rhizobia Associated with Jack Bean (Canavalia ensiformis L.) Nodulation in Eswatini

Improving the efficiency of the legume–rhizobia symbiosis in African soils for increased grain yield would require the use of highly effective strains capable of nodulating a wide range of legume plants. This study assessed the photosynthetic functioning, N2 fixation, relative symbiotic effectiveness (%RSE) and C assimilation of 22 jack bean (Canavalia ensiformis L.) microsymbionts in Eswatini soils as a first step to identifying superior isolates for inoculant production. The results showed variable nodule number, nodule dry matter, shoot biomass and photosynthetic rates among the strains tested under glasshouse conditions. Both symbiotic parameters and C accumulation differed among the test isolates at the shoot, root and whole-plant levels. Although 7 of the 22 jack bean isolates showed much greater relative symbiotic efficiency than the commercial Bradyrhizobium strain XS21, only one isolate (TUTCEeS2) was statistically superior to the inoculant strain, which indicates its potential for use in inoculant formulation after field testing. Furthermore, the isolates that recorded high %RSE elicited greater amounts of fixed N.
Effects of Leymus chinensis hay and alfalfa hay on growth performance, rumen microbiota, and untargeted metabolomics of meat in lambs

Objective The objective of this study was to compare the effects of Leymus chinensis hay and alfalfa hay as the roughage on the rumen bacterial and the meat metabolomics in lambs. Methods Fourteen male lambs were randomly assigned to two dietary treatments (one group was fed with concentrate and Leymus chinensis hay; another was fed with concentrate and alfalfa hay) with seven replicates per treatment. The feeding experiment lasted for 60 days. Lambs were slaughtered at the end of the feeding experiment. Growth performance, carcass performance, and weights of various viscera were determined. The longissimus dorsi and rumen contents were collected for untargeted metabolomics and 16S rDNA amplicon sequencing analysis, respectively. Results The lambs fed with alfalfa hay showed a significantly increased in average daily gain, carcass weight, dressing percentage, loin-eye area, and kidney weight. Feeding Leymus chinensis hay and alfalfa hay diets resulted in different meat metabolite deposition and rumen bacterial communities in the lambs. The relative abundance of phyla Fibrobacteres, Bacteroidetes, and Spirochaetes were greater in the Leymus Chinensis hay group, while, the relative abundance of Firmicutes, Proteobacteria, Fusobacteria, and Verrucomicrobia were greater in the alfalfa hay group. Based on untargeted metabolomics, the main altered metabolic pathways included alanine, aspartate and glutamate metabolism, D-glutamine and D-glutamate metabolism, phenylalanine metabolism, nitrogen metabolism, and tyrosine metabolism. Several bacteria genera including BF31, Alistipes, Faecalibacterium, Eggerthella, and Anaeroplasma were significantly correlated with growth performance and meat metabolites. Conclusion Alfalfa hay improved growth performance and carcass characteristics in lambs. Leymus chinensis hay and alfalfa hay caused different meat metabolite deposition by modifying the rumen bacterial community. These findings will be beneficial to future forage utilization for sheep growth, carcass performance, and meat quality improvement.
Dietary Resistant Starch Regulates Bile Acid Metabolism by Modulating the FXR/LRH-1 Signaling Pathway in Broilers

This study aimed to investigate the effects of dietary corn-resistant starch on the bile acid metabolism of broilers. In total, 80, 1-day-old male broilers were randomly distributed into two groups fed either the basic normal corn–soybean diet or a diet supplemented with 40 g/kg of corn-resistant starch. The results showed that dietary supplementation of 4% corn-resistant starch increased the F/G during the periods from 21 to 42 d. Resistant starch supplementation reduced the lipid levels in plasma, and the contents of total bile acids were increased with the altered bile acid profile in the ileum. A diet with corn resistant starch decreased the enzyme contents of the classical pathway of bile acid synthesis and activated the signaling pathway of FXR/LRH-1 in the liver. A decreased abundance of Clostridium cluster XIVa was found in the ileal digesta of the resistant starch group, and its abundance was negatively correlated with the level of lithocholic acid. In summary, the RS was effective at reducing broiler plasma and liver lipid levels, which was probably due to the change in bile acid synthesis and reabsorption capacities. These findings provided a unique landscape of the relationship between bile acid metabolism and resistant starch in broilers.
Deep-Learning-Aided Intraframe Motion Correction for Low-Count Dynamic Brain PET

Data-driven intraframe motion correction of a dynamic brain PET scan (with each frame duration on the order of minutes) is often achieved through the co-registration of high-temporal-resolution (e.g., 1-s duration) subframes to estimate subject head motion. However, this conventional method of subframe co-registration may perform poorly during periods of low counts and/or drastic changes in the spatial tracer distribution over time. Here, we propose a deep learning (DL), U-Net-based convolutional neural network model which aids in the PET motion estimation to overcome these limitations. Unlike DL models for PET denoising, a nonstandard 2.5-D DL model was used which transforms the high-temporal-resolution subframes into nonquantitative DL subframes which allow for improved differentiation between noise and structural/functional landmarks and estimate a constant tracer distribution across time. When estimating motion during periods of drastic change in spatial distribution (within the first minute of the scan, ~1-s temporal resolution), the proposed DL method was found to reduce the expected magnitude of error (+/−) in the estimation for an artificially injected motion trace from 16 mm and 7° (conventional method) to 0.7 mm and 0.6° (DL method). During periods of low counts but a relatively constant spatial tracer distribution (60th min of the scan, ~1-s temporal resolution), an expected error was reduced from 0.5 mm and 0.7° (conventional method) to 0.3 mm and 0.4° (DL method). The use of the DL method was found to significantly improve the accuracy of an image-derived input function calculation when motion was present during the first minute of the scan.
DLL4/Notch3/WNT5B axis mediates bidirectional prometastatic crosstalk between melanoma and lymphatic endothelial cells

Despite strong indications that interactions between melanoma and lymphatic vessels actively promote melanoma progression, the molecular mechanisms are not yet completely understood. To characterize molecular factors of this crosstalk, we established human primary lymphatic endothelial cell (LEC) cocultures with human melanoma cell lines. Here, we show that coculture with melanoma cells induced transcriptomic changes in LECs and led to multiple changes in their function. WNT5B, a paracrine signaling molecule upregulated in melanoma cells upon LEC interaction, was found to contribute to the functional changes in LECs. Moreover, WNT5B transcription was regulated by Notch3 in melanoma cells following the coculture with LECs, and Notch3 and WNT5B were coexpressed in melanoma patient primary tumor and metastasis samples. Moreover, melanoma cells derived from LEC coculture escaped efficiently from the primary site to the proximal tumor-draining lymph nodes, which was impaired upon WNT5B depletion. This supported the role of WNT5B in promoting the metastatic potential of melanoma cells through its effects on LECs. Finally, DLL4, a Notch ligand expressed in LECs, was identified as an upstream inducer of the Notch3/WNT5B axis in melanoma. This study elucidated WNT5B as a key molecular factor mediating bidirectional crosstalk between melanoma cells and lymphatic endothelium and promoting melanoma metastasis.
On the Conditional Frazil Ice Instability in Seawater

AbstractIt has been suggested that the presence of frazil ice can lead to a conditional instability in seawater. Any frazil forming in the water column reduces the bulk density of a parcel of frazil–seawater mixture, causing it to rise. As a result of the pressure decrease in the freezing point, this causes more frazil to form, causing the parcel to accelerate, and so on. This study uses linear stability analysis and a nonhydrostatic ocean model to study this instability. The authors find that frazil ice growth caused by the rising of supercooled water is indeed able to generate a buoyancy-driven instability. Even in a gravitationally stable water column, the frazil ice mechanism can still generate convection. The instability does not operate in the presence of strong density stratification, high thermal driving (warm water), a small initial perturbation, high background mixing, or the prevalence of large frazil ice crystals. In an unstable water column, the instability is not necessarily expressed in fra.
The Progressive Utilization of Ponkan Peel Residue for Regulating Human Gut Microbiota through Sequential Extraction and Modification of Its Dietary Fibers

As a by-product of citrus processing, ponkan (Citrus reticulata Blanco, cv. Ponkan) peel residue is a source of high quality dietary fiber (DF). To make a full utilization of this resource and give a better understanding on the probiotic function of its DF, soluble dietary fiber (SDF) and insoluble dietary fiber (IDF) were extracted from ponkan peel residue (after flavonoids were extracted) using an alkaline method, followed by modifications using a composite physical-enzymatic treatment. The in vitro fermentation properties of the modified SDF and IDF (namely, MSDF and MIDF) and their effects on short-chain fatty acids (SCFA) production and changes in the composition of human gut microbiota were investigated. Results showed that MSDF and MIDF both significantly lowered the pH value and enhanced total SCFA content in the broths after fermented for 24 h by fecal inocula (p < 0.05) with better effects found in MSDF. Both MSDF and MIDF significantly reduced the diversity, with more in the latter than the former, and influenced the composition of human gut microbiota, especially increasing the relative abundance of Bacteroidetes and decreasing the ratio of Firmicutes to Bacteroidetes (F/B) value. The more influential microbiota by MSDF were g-Collinsella, p-Actinobacteria and g-Dialister, while those by MIDF were f-Veillonellaceae, c-Negativicutes and f-Prevotellacese. These results suggested that the modified ponkan peel residue DF can be utilized by specific bacteria in the human gut as a good source of fermentable fiber, providing a basis for the exploitation of the citrus by-product.
Photochemical Models In The Air QualityManagement Plan Of A Complex Coastal Area

The present paper reports the study of actual and future photochemical pollution with CALMET and CALGRID models in the congested urban, harbour and industrial area of Genoa (Italy) in the frame of a Regional Air Quality Management Plan. The data in input are briefly discussed respect to meteorological data and speciated and time resolved emissions inventory. CALGRID model sensibility to boundary and initial conditions is analyzed with reference to ozone and nitrogen oxides. The results of the good comparison between ozone concentration data coming from simulation and from some monitoring stations are reported. The CALGRID model application to the emissions projected in time up to year 2010 in a "do nothing scenario" (with application of existing new normative) and in a "plan scenario" (taking into account several emissions reduction measures) is discussed. To conclude the paper shows that high reductions of emissions allow avoiding photochemical smog critical episodes and producing a migration of ozone peaks toward suburban areas.
Determinants of Mergers and Acquisitions in Emerging Asian Countries: Effects of Confucianism and Technological Development

Asian emerging markets exemplify the contemporary trend of glocalization (globalization-localization). Countries in this region have strong cultural bonds shaped by the influence of Confucianism, which has given rise to a distinctive approach to conducting business, including the realm of mergers and acquisitions. The homogeneity of cultural values fosters trust among parties even in cross-border transactions, impacting the assessment of transaction premiums. Simultaneously, within this region, a cluster of Asian Tiger countries distinguishes itself by leading in technological advancements, particularly in the realm of digitalization. The escalating competitiveness of technologically advanced companies further influences estimates of transaction premiums. This paper endeavors to delve into the theoretical aspects of these issues and substantiate, through empirical evidence, the cultural impact of Confucianism and technological progress on mergers and acquisitions (M&A). Our research is grounded in a database encompassing 2677 cross-border deals compiled from January 1, 2002, to January 1, 2021, for 10 burgeoning Asian markets. This study marks the first exploration of M&A deal value and firm valuation during transactions utilizing a glocal region as a case study. Our primary findings substantiate the notion that cultural affinities exert a substantialinfluence on M&A deal values, with a propensity for lower values among culturally similar countries. Congruent cultural values build trust among stakeholders and safeguard from additional risks. These results give policymakers and business entities an opportunity to adjust their decisions and refine their comprehension of factors that shape the economy.
Ensemble Monitoring Model Based on Multi-Subspace Partition of Deep Features

Traditional deep neural network (DNN) based process monitoring methods only use the deep features of the last layer and residuals to achieve fault detection. However, the features in different hidden layers are different representations of the input data, which may be beneficial to process monitoring. Only using the deepest features for process monitoring will cause the problems of information loss and low monitoring performance. To obtain more useful information for fault detection, this paper considers the features in all hidden layers and proposed an ensemble monitoring model based on multi-subspace partition of deep features. Firstly, a DNN model is established based on the collected faultless data to obtain the features in all hidden layers and residuals. Secondly, a new feature matrix is constructed based on the retained deep features and residuals. Then, the multi-subspace partition of the new feature matrix is realized by combining correlation analysis and cluster analysis. Finally, the monitoring statistics that are established based on the features in each subspace are fused to realize process monitoring. The proposed method can not only reduce information loss but also enrich the fault-related information. The monitoring performance is verified through two benchmark processes and one actual industrial process.