Miracle-dz/UniFAR-FTUs huggingface dataset:
Nuclear Medicine in Cancer Theranostics: Beyond the Target

the choice being whether to remain a peripheral diagnostic lesion-detection technique competing against the ever-evolving anatomic imaging modalities or whether to join the revolution in precision medicine, characterizing tumor biology and directing treatment through highly speciﬁc tracers. The term theranostics encapsulates the integra-tion of diagnostics and therapeutics in the individualized management of disease ( 1 ). Implicit in the theranostic paradigm is the assumption that diagnostic test results can precisely determine whether an individual is likely to beneﬁt from a speciﬁc treatment. This assumption underpins the recent focus on companion diagnostics as an integral part of drug development. An excellent example of the concept of theranostics in oncology is the requirement that, to be selected for trastuzumab therapy (Herceptin; Genentech), a candidate must have a tumor on which the presence of human epidermal growth factor receptor 2 (HER2) has been demonstrated. However, this requirement is limited by the potential sampling bias intrinsic in tissue biopsy. Molecular imaging of HER2 expression using 89 Zr-radiolabeled trastuzumab provides an alternative vision of how the selection of candidates for expensive and sometimes toxic therapies might look in the future ( 2 ). Molecular imaging with 89 Zr-trastuzumab can be used to detect heterogeneity of HER2 expression. Because it can image the whole body, it has the potential to improve selection of patients for trastuzumab
Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine

Mesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the root apical papilla of human teeth (SCAP, stem cells from apical papilla). Using a minipig model, we transplanted both human SCAP and periodontal ligament stem cells (PDLSCs) to generate a root/periodontal complex capable of supporting a porcelain crown, resulting in normal tooth function. This work integrates a stem cell-mediated tissue regeneration strategy, engineered materials for structure, and current dental crown technologies. This hybridized tissue engineering approach led to recovery of tooth strength and appearance.
Communication Education: The Spiral Continues

Anniversaries of all kinds provide wonderful opportunities for contemplation and rededication. For that reason I welcomed Editor Joe Ayre’s invitation to think about the history and the future of our journal. I am particularly honored to share this reflective space with Professor Loren Reid. I first read his Teaching Speech in 1964 as part of Margaret Woods’ speech methods class at Northern Illinois University and its special blend of idealism, pragmatism and whimsy filled me with hope as I shakily approached my student teaching assignment. I remember the feeling that I was being welcomed into a very special community of people—speech teachers—and that I had found a calling that could provide enough rewards to delight me and interesting problems to challenge me throughout an entire career. And so I had. The journal, Speech Teacher, was accessible and helpful to me as a student teacher and a Teaching Assistant. In a sense, we have grown up together moving toward more “professional” and “scholarly” orientations. Without a doubt, neither the journal nor most of us who read it are appropriately labeled “speech teachers” anymore. I could never have anticipated the incredible range and sophistication of the work that would appear in the journal that became Communication Education or the kinds of activities that turned out to be entailed in my choice to become a communication educator and researcher. I take great pride in that evolution. Yet at this admittedly nostalgic moment, I also pause to hope that those entering our profession today are still invigorated by a sense of calling and a clarity of purpose. Our journal speaks for those of us who identify with communication education and instructional communication, providing a commentary on how far we have come and on where we might go next. In preparation of this essay, I have taken the last few months to revisit my personal collection of Speech Teacher and Communication Education, which is about 80% complete since 1971. I have read and reread the tables of contents in the NCA index, occasionally being driven to the library to track down a particularly intriguing title that predates those on my shelf. Along the way I carefully noted the editorial statements of each new editor, the arrival and departure of new sections of the journals, the themes of special issues, and summary and synthesis essays such as Staton-Spicer and Wulff (1984). My own involvement with the journal includes publication of a few articles and book reviews, membership on the editorial board off and on (more on) since 1976 and a term as Book Review editor. Among my files I found a sampling of my reviews and copies of what other reviewers and editors said about those same manuscripts. My initial goal of conducting a systematic content analysis of the journal for the last twenty-five years quickly gave way to a more impressionistic survey. I first report briefly on my observations as I revisited the fifty years, particularly
Shared Frailty Models for Recurrent Events and a Terminal Event

Summary There has been an increasing interest in the analysis of recurrent event data ( Cook and Lawless, 2002 , Statistical Methods in Medical Research11, 141–166). In many situations, a terminating event such as death can happen during the follow‐up period to preclude further occurrence of the recurrent events. Furthermore, the death time may be dependent on the recurrent event history. In this article we consider frailty proportional hazards models for the recurrent and terminal event processes. The dependence is modeled by conditioning on a shared frailty that is included in both hazard functions. Covariate effects can be taken into account in the model as well. Maximum likelihood estimation and inference are carried out through a Monte Carlo EM algorithm with Metropolis–Hastings sampler in the E‐step. An analysis of hospitalization and death data for waitlisted dialysis patients is presented to illustrate the proposed methods. Methods to check the validity of the proposed model are also demonstrated. This model avoids the difficulties encountered in alternative approaches which attempt to specify a dependent joint distribution with marginal proportional hazards and yields an estimate of the degree of dependence.
Quality inspection of printed texts

Inspecting the quality of printed texts has its own importance in many industrial applications. To do so, this paper proposes a grading system which evaluates the performance of the printing task using some quality measures for each character and symbols. The purpose of these grading system is two-folded: for costumers of the printing and verification system, the overall grade used to verify if the text is of sufficient quality, while for printer's manufacturer, the detailed character/symbols grades and quality measurements are used for the improvement and optimization of the printing task. The proposed system has been tested on images from a real industrial environment and the obtained results are promising.
Computational materials design of negative effective U system in hole-doped chalcopyrite CuFeS2

A general rule of negative effective U(Ueff) system caused by (i) exchange correlation and (ii) charge excitation mechanisms is proposed. Based on the general rule, we perform ab initio electronic structure calculations by generalized gradient approximation (GGA) + U method for hole-doped chalcopyrite CuFeS2 [Cu+(d10)Fe3+(d5)S2−(s2p6)2]. It is found from our calculations that the hole-doped CuFeS2 has the negative Ueff = −0.44 eV, where Ueff ≡ E(N + 1) + E(N − 1) − 2E(N) < 0 and E(N) is the total energy of the hole-doped CuFeS2. The negative Ueff is caused by the charge-excitation in the hole-doped Cu2+(d9) and S−(s2p5), and also caused by the exchange-correlation in the hole-doped Fe4+(d4). The strong attractive electron–electron interaction (Ueff = −0.44 eV ∼ −5000 K) originates from the purely electronic mechanism. The closed shell of the d10 electronic configuration is more stable than the d9 electronic configuration, since the first excited state with the d9s1 electronic configuration and the ground state with the d10 electronic configuration are very close, then these two states repel very strongly through the second order perturbation. Therefore, the spin-polarized total energy curve for the hole-doped CuFeS2 shows the strong upward convexity with N − 1, N and N + 1 electronic configurations leading to the negative Ueff. The hole-doped paramagnetic and metallic CuFeS2 with the negative Ueff may cause a possible high-Tc superconductor (Tc ∼ 1000 K, if 2Δ/kBTc ≈ 10 by assuming a strong coupling regime) because of the strong attractive electron–electron interactions (superconducting gap Δ ≈ |Ueff| ∼ 5000 K). Finally, we propose a new computational materials design methodology to design ultra high-Tc superconductors by using three steps starting from the atomic number only.
Directed transport in classical and quantum chaotic billiards

We construct an autonomous chaotic Hamiltonian ratchet as a channel billiard subdivided by equidistant walls attached perpendicularly to one side of the channel, leaving an opening on the opposite side. A static homogeneous magnetic field penetrating the billiard breaks time-reversal invariance and renders the classical motion partially chaotic. We show that the classical dynamics exhibits directed transport, owing to the asymmetric distribution of regular regions in phase space. The billiard is quantized by a numerical method based on a finite-element algorithm combined with the Landau gauge and the Bloch formalism for periodic potentials. We discuss features of the billiard eigenstates such as node lines and vortices in the probability flow. Evidence for directed quantum transport, inherited from the corresponding features of the classical dynamics, is presented in terms of level-velocity statistics.
Toward a holistic model of organizational effectiveness and organizational development at different stages of growth

This article, which is based on Eric Flamholtz's more than seventeen years of observations of organizations (from small entrepreneur-ships to Fortune 500 firms), molds a holistic framework from a synthesis of the organizational effectiveness model and the organizational life-cycle model. Of special interest to HRD professionals are the recommendations regarding the role of human resources in four of the six tasks of organizational development: in the acquisition of resources, in the development of operational systems, in the refining of management systems, and in the shaping of the corporation's culture.
DIFFERENTIAL MODELS FOR MATH ANXIETY IN MALE AND FEMALE COLLEGE STUDENTS

The relative importance of several predictors of math anxiety were examined in multiple regression models. The predictors were test anxiety, ACT math scores, student perceptions of high-school math teachers' teaching ability (PHAM), student perceptions of college math teachers' teaching ability (PCAM), parental support for math skills (PSM), the length of time since completing high-school, number of college math classes taken, perceived math ability (PMA), and gender. No significant difference was found between the genders for amount of math anxiety. However, when separate analyses were conducted for males and females, different factors were significant for each gender. Specifically, males' math anxiety was most strongly related to general test anxiety and ACT math scores. Predictably, males' math anxiety increased as ACT math scores declined and test anxiety increased. In contrast, females' math anxiety was most strongly affected by students' PMA, PHAM, ACT, and general test anxiety. Females' math anxiety increased as PMA and PHAM declined. General test anxiety was positively related to math anxiety. Surprisingly, females' math anxiety increased as ACT math scores increased in the model. Explanations for the latter finding and recommendations for reducing math anxiety are discussed.
Exacerbation of acute inflammatory arthritis by the colony‐stimulating factors CSF‐1 and granulocyte macrophage (GM)‐CSF: evidence of macrophage infiltration and local proliferation

CSF‐1 and GM‐CSF have been implicated in the pathogenesis of rheumatoid arthritis. We report the effects of CSF‐1 and GM‐CSF in the development of an acute methylated bovine serum albumin (mBSA)‐induced murine arthritis model. Examination of histopathological features revealed that the systemic administration of CSF‐1 or GM‐CSF following mBSA administration into the knee resulted in the exacerbation of arthritis. This included synovial hyperplasia and joint inflammation, most evident at 7 and 14 days post‐mBSA administration, and the appearance of erosive pannus tissue. The exacerbation by CSF‐1 and GM‐CSF was not sustained but declined in incidence and severity by 21 days post‐mBSA administration, similar to the effects of IL‐1β in this model, reported here and previously. Macrophages expressing Mac‐2 and F4/80 were a prominent feature of the pathology observed, particularly the infiltration of Mac‐2+ macrophages seen in all mice administered CSF‐1, GM‐CSF or IL‐1β. Present in inflamed knees was a locally dividing population of cells which included Mac‐2+ and F4/80+ macrophages. These studies demonstrate that CSF‐1 and GM‐CSF can exacerbate and prolong the histopathology of acute inflammatory arthritis and lend support to monocytes/macrophages being a driving influence in the pathogenesis of inflammatory arthritis.
Dynamic Channel Allocation Mechanism Based on Characteristic Matching in Cognitive Wireless Network

Cognition concept and dynamic spectrum allocation (DSA) technique are applied in cognitive wireless network to increase spectrum utilization efficiency and alleviate network congestion. Due to the dynamic and random characteristic of radio environment in cognitive wireless network, this paper brings forward a dynamic channel allocation mechanism to minimize the probability of collision with the licensed users and improve the performance of cognitive wireless network. Matching rules are set forth by considering relationship between spectrum statistic characteristic and service characteristic adequately. Furthermore, a multi-objective terminal selection algorithm is designed to minimize the system overhead and the impact on end-users. Simulation results manifest that the proposed scheme is effective in improving the performance of cognitive wireless network, reducing the spectrum handoff times and minimizing the collision probability.
Multi-microphone Signal Processing for Automatic Speech Recognition in Meeting Rooms

Performance of current speech recognition systems severely degrades in the presence of noise and reverberation. While rather simple and effective noise reduction techniques have been extensively applied, coping with reverberation still remains as one of the toughest problems in speech recognition and signal processing. Single-microphone dereverberation algorithms typically result in very low speech recognition performance. Taking advantage of multiple-microphones popularity and theoretical achievements such as the MINT theorem, blind multiple-microphone signal processing techniques are explored and evaluated in several speech recognition test-beds. These include connected digits recognition in meeting rooms and matched and mismatched training-test conditions as well as conversational speech recognition in meetings in mismatched training-test conditions. Multi-channel equalization techniques are shown to be effective under explicit knowledge of either speaker-to-receiver impulse response or order determination, but not in real situations. Blind dereverberation techniques based on time-delay estimation, such as delay-and-sum, delay-and-feature-domain-sum and phase-error based filtering are shown to significantly improve recognition accuracy over a single distant microphone, while being robust enough for real noisy and reverberant speech. Dereverberation techniques based on linear prediction are introduced and multi-channel correlation shaping is further explored for speech recognition. It is shown to improve recognition accuracy of a single distant microphone only in some situations. xv
What do isogamous organisms teach us about sex and the two sexes?

Isogamy is a reproductive system where all gametes are morphologically similar, especially in terms of size. Its importance goes beyond specific cases: to this day non-anisogamous systems are common outside of multicellular animals and plants, they can be found in all eukaryotic super-groups, and anisogamous organisms appear to have isogamous ancestors. Furthermore, because maleness is synonymous with the production of small gametes, an explanation for the initial origin of males and females is synonymous with understanding the transition from isogamy to anisogamy. As we show here, this transition may also be crucial for understanding why sex itself remains common even in taxa with high costs of male production (the twofold cost of sex). The transition to anisogamy implies the origin of male and female sexes, kickstarts the subsequent evolution of sex roles, and has a major impact on the costliness of sexual reproduction. Finally, we combine some of the consequences of isogamy and anisogamy in a thought experiment on the maintenance of sexual reproduction. We ask what happens if there is a less than twofold benefit to sex (not an unlikely scenario as large short-term benefits have proved difficult to find), and argue that this could lead to a situation where lineages that evolve anisogamy—and thus the highest costs of sex—end up being associated with constraints that make invasion by asexual reproduction unlikely (the ‘anisogamy gateway’ hypothesis). This article is part of the themed issue ‘Weird sex: the underappreciated diversity of sexual reproduction’.
The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype

We have prepared a monoclonal antibody, KJ16-133, from the cells of a rat immunized with the purified receptor for antigen plus I-A of a BALB/c T cell hybridoma, DO-11.10. Unlike most other monoclonal anti- receptor antibodies that have been described before, KJ16-133 is not clone specific. It reacts with approximately 20% of the receptors on T cells of normal BALB/c mice. It also reacts with about the same percentage of antigen-specific, major histocompatibility complex (MHC)- restricted or allogeneic I-region specific T cell hybridomas. Reaction of KJ16-133 with a given T cell hybridoma does not seem to depend on the antigen specificity or MHC-restricting element of the T cell in question. The determinant recognized by KJ16-133 has some unexpected properties. It is absent in several strains of mice including SJL/J and SJA/20, but present on the T cells of most other commonly used strains. The determinant recognized therefore does not map to Igh. Our experiments suggest that a clone-specific "antiidiotypic" antibody and KJ16-133 recognize determinants on different parts of the receptor. For example, the binding of a clone-specific antibody to target T cells is relatively temperature insensitive, whereas KJ16-133 binds well to cells at 37 degrees C but poorly to cells at 4 degrees C. The determinant recognized by a clone-specific antibody is sensitive to reduction and alkylation of the receptor, whereas KJ16-133 reactivity is not. Finally, binding of KJ16-133 at saturating concentrations to target T cells does not block the binding of a clone-specific antibody. Similarly, binding of a clone-specific antibody only marginally inhibits binding of KJ16-133. Taken together, these results suggest that KJ16-133 is directed against an allelic determinant on T cells that may be close to the membrane, and not in the receptor binding site for antigen plus MHC. The antibody may recognize an allele of a constant region isotype, or an allele of a J region.
Listening to Men's Stories: Overcoming Obstacles to Intimacy from Childhood

This article analyzes the interviews of five men who came from abusive or otherwise unhealthy families to understand how they were able to overcome obstacles from their childhood to be more intimate with their own families. The five respondents were chosen from a sample of 103 White, married men ranging in age from 40 to 50 based on their extreme high scores on the Miller Social Intimacy Scale and their extreme low scores on the Family of Origin Scale. Content analysis of interviews allowed themes to emerge that revealed how the five men were able to change their life stories. Their responses fall into three categories that are explored in this paper: (1) childhood role models and alternative caregivers, (2) childhood friends, and (3) transforming experiences in later life. Interview excerpts provide examples of each category. Narrative analysis provided a deeper understanding of the interviews by exploring how the men used language to convey meaning. Attention was paid to the words the men chose, pauses, tone and delivery of speech, and metaphors. Noticing the details of language and how people story their lives adds to knowledge about clients.
Cutaneous oncology.

Will reading habit influence your life? Many say yes. Reading cutaneous oncology is a good habit; you can develop this habit to be such interesting way. Yeah, reading habit will not only make you have any favourite activity. It will be one of guidance of your life. When reading has become a habit, you will not make it as disturbing activities or as boring activity. You can gain many benefits and importances of reading.
Identity-based Trusted Authentication in Wireless Sensor Network

Secure communication mechanisms in Wireless Sensor Networks (WSNs) have been widely deployed to ensure confidentiality, authenticity and integrity of the nodes and data. Recently many WSNs applications rely on trusted communication to ensure large user acceptance. Indeed, the trusted relationship thus far can only be achieved through Trust Management System (TMS) or by adding external security chip on the WSN platform. In this study an alternative mechanism is proposed to accomplish trusted communication between sensors based on the principles defined by Trusted Computing Group (TCG). The results of other related study have also been analyzed to validate and support our findings. Finally the proposed trusted mechanism is evaluated for the potential application on resource constraint devices by quantifying their power consumption on selected major processes. The result proved the proposed scheme can establish trust in WSN with less computation and communication and most importantly eliminating the need for neighboring evaluation for TMS or relying on external security chip.