Miracle-dz/UniFAR-FTUs huggingface dataset:
Pedometer indices for weekly physical activity recommendations in postmenopausal women.

PURPOSE The aim of this study was to quantify pedometer-determined steps per day associated with 50, 100, and 150% of the current public health recommendation for weekly physical activity in sedentary postmenopausal women. METHODS A sample of 111 women from the DREW (Dose Response to Exercise in Women) study provided data. We randomly assigned women into one of three exercise groups expending 4, 8, or 12 kcal(-1). kg(-1). wk(-1) (KKW). Participants exercised alternately on a treadmill and recumbent cycle ergometer for a 6-month training period. Only treadmill sessions done with zero grade, at slow to moderate speeds (48-97 m.min(-1)) were used in this analysis. We controlled intensity at a HR equivalent to 50% of VO(2peak). Participants wore pedometers at baseline and throughout the study to assess their free-living physical activity (steps.d(-1)) RESULTS Baseline averages were <5400 steps.d(-1) for the 4-, 8-, and 12-KKW groups. During 6 months of exercise training, free-living step counts remained <5400 steps.d(-1) and did not significantly differ from baseline for each group. Average speeds and distances per exercise session were 2.7 +/- 0.4 mph, 1.2 +/- 0.2 miles (4 KKW), 2.6 +/- 0.4 mph, 2.2 +/- 0.4 miles (8 KKW), and 2.8 +/- 0.3 mph, 2.7 +/- 0.4 miles (12 KKW). This yielded 2771 (4 KKW), 5457 (8 KKW), and 6534 (12 KKW) steps per exercise session 3-4 d.wk(-1). CONCLUSIONS Initially sedentary postmenopausal women can meet 50% (4 KKW), 100% (8 KKW), and 150% (12 KKW) of the current public health recommendation of weekly physical activity through planned moderate-intensity walking, accumulating an average of about 2800 (50%), 5500 (100%), and 6500 steps.d(-1) (150%) 3-4 d.wk(-1).
Pattern of muscle injuries and predictors of return-to-play duration among Malaysian athletes.

INTRODUCTION The purpose of this study was to investigate the pattern of muscle injuries and the factors that predict the return-to-play duration among Malaysian athletes. METHODS This is a retrospective review of the case notes of athletes who attended the National Sports Institute Clinic in Malaysia. The medical records of athletes with muscle injury, diagnosed on clinical assessment and confirmed by diagnostic ultrasonography, were included for final analysis. RESULTS From June 2006 to December 2009, 397 cases of muscle injury were diagnosed among 360 athletes. The median age of the athletes with muscle injuries was 20.0 years. Muscle injuries were mostly diagnosed among national-level athletes and frequently involved the lower limb, specifically the hamstring muscle group. Nearly all of the athletes (99.2%) were treated conservatively. The median return-to-play duration was 7.4 weeks. Athletes who waited more than one week before seeking medical attention, those with recurrent muscle injuries and female athletes were significantly more likely (p < 0.05) to take more than six weeks before returning to the sport. CONCLUSION Grade 2 lower limb muscle injury was commonly diagnosed among national-level athletes in this study. The frequency of weekly physiotherapy sessions did not affect the return-to-play duration. Factors such as initial consultation at more than one week post injury, recurrent muscle injuries and female gender were significant predictors of return-to-play duration among Malaysian athletes. These predictive factors should be kept in mind during clinical assessment so as to aid in prognosticating recovery after muscle injury.
News Content Homogeneity in Elite Indian Dailies

Review of Literature Defining news, many people say, is trying to d o the impossible. Yet many have fek the need to deal with the question of news definition. The question may seem to belong to a sphere of abstraction or philosophy. But newspeople pursue their job of gathering and presenting news as a practical calling in a world of hard realities. Definitions of news attempted so far range ' J . Herbert Allrhull has quoted a well-known U.S. TV anchor person as saying: "New is what I say it is. " See J. Herbert Altschull in "What is News," Mass Comm Review. December 1974. p. 17; Turner Calledge. a former editor of the New York Times said: "My own definition of news is that it is something you didn't know before. had forgotten. or didn't understand. " xt Dennis J. Chase. 'The Aphilosophy of Journalism. " The Quill, September. 1971. p. 16. Johan Galtung and Mari Rugc. "Structuring and Selecting News. " in Stanley Cohen and Jack Young. eds. Ttw Manufaclure of News: Lhian'e. Social Problems and The Mass Media (Beverly Hills. Calif.: Sage Publications. 1973). pp. 62-73. J John Dimmick. 'The Gatekeeper: An Uncertain Theory. " Journalism Monqraphs. No. 37 ( 1974). from handy, catchy or capricious personal observations of practicing professionals t o abstruse formulations by journalism scholars.1 Newspeople in the market-oriented system are assumed t o apply their news values in the selection of news consciously or intuitively. The story appeal is believed to depend upon the presence of such elements. The greater the number of elements in a story, the greater is its appeal. While Third World newspeople are undoubtedly exposed to these news values through early socialization and enculturation, excessive emphasis on these is likely to conflict with what seems to be a n emerging Third World notion of news values represented by such concepts as developing journalism. Galtung and Ruge in a n insightful, theoretical discussion on how international news is selected and structured presented a list of 12 news factors and some general hypotheses to explain their view of newsworthiness. These, for the most part, seem to apply to all news, both national and international.2 Dimmick states that a gatekeeper has to reduce the uncertainty that his news judgment is correct and valid by relying on judgments of colleagues, professional opinion leaders, reference institutions, news sources and group-related attitudes and values. ) Dimmick also suggests that a gatekeeper's news selection decisions are
A Meta-Analysis of School-Based Social Skills Interventions for Children With Autism Spectrum Disorders

Social skills deficits are a central feature of autism spectrum disorders (ASD). This meta-analysis of 55 single-subject design studies examined the effectiveness of school-based social skills interventions for children and adolescents with ASD. Intervention, maintenance, and generalization effects were measured by computing the percentage of non-overlapping data points. The results suggest that social skills interventions have been minimally effective for children with ASD. Specific participant, setting, and procedural features that lead to the most effective intervention outcomes are highlighted, and implications for school personnel are discussed. Finally, the results are compared to the outcomes of similar meta-analyses involving social skills interventions with other populations of children.
Percent change in wound area of diabetic foot ulcers over a 4-week period is a robust predictor of complete healing in a 12-week prospective trial.

OBJECTIVE To assess the ability of the 4-week healing rate to predict complete healing over a 12-week period in a large prospective multicenter trial of diabetic patients with foot ulceration. RESEARCH DESIGN AND METHODS We examined the change in ulcer area over a 4-week period as a predictor of wound healing within 12 weeks in patients who were seen weekly in a prospective, randomized controlled trial. RESULTS Wound area measurements at baseline and after 4 weeks were performed in 203 patients. The midpoint between the percentage area reduction from baseline at 4 weeks in patients healed versus those not healed at 12 weeks was found to be 53%. Subjects with a reduction in ulcer area greater than the 4-week median had a 12-week healing rate of 58%, whereas those with reduction in ulcer area less than the 4-week median had a healing rate of only 9% (P < 0.01). The absolute change in ulcer area at 4 weeks was significantly greater in healers versus nonhealers (1.5 versus 0.8 cm2, P < 0.02). The percent change in wound area at 4 weeks in those who healed was 82% (95% CI 70-94), whereas in those who failed to heal, the percent change in wound area was 25% (15-35; P < 0.001). CONCLUSIONS The percent change in foot ulcer area after 4 weeks of observation is a robust predictor of healing at 12 weeks. This simple tool may serve as a pivotal clinical decision point in the care of diabetic foot ulcers for early identification of patients who may not respond to standard care and may need additional treatment.
Low-cost mechanically steered millimeter-wave lens antenna system for indoor LANs

The expected need in the near-future to increase the data rate of personal communication systems up to a few GBit/s, calls for the possibility to explore the millimeter wave part of the electromagnetic spectrum especially for very short range indoor radio links to replace for instance the current Bluetooth or other domestic Personal Area Networks (PANs). High gain antennas in the order of 20 dBi are required to favor the link budget at these frequencies, but the antenna directionality limits user mobility unless at least one antenna in the link can automatically track the other antenna. A new antenna concept that is appropriate for this objective was recently developed by the authors. The objective of this paper is to demonstrate the complete concept by integrating the developed antenna with a simplified RF front-end for data transmission, along with the tracking control system and required algorithms so that a fully operational video transmission can be accomplished with this wireless mm-wave system using low-cost solutions.
Skin Barrier Function and Staphylococcus aureus Colonization in Vestibulum Nasi and Fauces in Healthy Infants and Infants with Eczema: A Population-Based Cohort Study

Atopic eczema (AE) is associated with Staphylococcus aureus (S. aureus) colonization and skin barrier dysfunction, often measured by increased transepidermal water loss (TEWL). In the present study, the primary aim was to see whether S. aureus colonization in the vestibulum nasi and/or fauces was associated with increased TEWL in infants with healthy skin and infants with eczema. Secondarily, we aimed to investigate whether TEWL measurements on non-lesional skin on the lateral upper arm is equivalent to volar forearm in infants. In 167 of 240 infants, recruited from the general population, TEWL measurements on the lateral upper arm and volar forearm, using a DermaLab USB, fulfilled our environmental requirements. The mean of three TEWL measurements from each site was used for analysis. The infants were diagnosed with no eczema (n = 110), possible AE (n = 28) or AE (n = 29). DNA samples were analysed for mutations in the filaggrin gene (FLG). Bacterial cultures were reported positive with the identification of at least one culture with S. aureus from vestibulum nasi and/or fauces. S. aureus colonization, found in 89 infants (53%), was not associated with increased TEWL (i.e. TEWL in the upper quartile), neither on the lateral upper arm or volar forearm (p = 0.08 and p = 0.98, respectively), nor with AE (p = 0.10) or FLG mutation (p = 0.17). TEWL was significantly higher on both measuring sites in infants with AE compared to infants with possible AE and no eczema. FLG mutation was significantly associated with increased TEWL, with a 47% difference in TEWL. We conclude that S. aureus in vestibulum nasi and/or fauces was not associated with TEWL, whereas TEWL measurements on the lateral upper arm and volar forearm appear equally appropriate in infants.
The Long Road to the Fast Track: Career and Family

The career and family outcomes of college graduate women suggest that the twentieth century contained five distinct cohorts. The first cohort, graduating college from 1900 to 1920, had either “family or career. ” The second, graduating from 1920 to 1945, had “job then family. ” The third cohort, the college graduate mothers of the baby boom, graduated from 1946 to the mid1960s and had “family then job. ” Among the fourth cohort, graduating college from the late 1960s to 1980 and whose stated goal was “career then family,” 13 to 18 percent achieved both by age forty. The objective of the fifth cohort, graduating from around 1980 to 1990, has been “career and family,” and 21 to 28 percent have realized that goal by age forty. The author traces the demographic and labor force experiences of these five cohorts of college graduates and discusses why “career and family” outcomes changed over time.
A local algorithm for finding dense subgraphs

We describe a local algorithm for finding subgraphs with high density, according to a measure of density introduced by Kannan and Vinay [1999]. The algorithm takes as input a bipartite graph <i>G</i>, a starting vertex <i>v</i>, and a parameter <i>k</i>, and outputs an induced subgraph of <i>G</i>. It is local in the sense that it does not examine the entire input graph; instead, it adaptively explores a region of the graph near the starting vertex. The running time of the algorithm is bounded by <i>O</i>(Δ <i>k</i><sup>2</sup>), which depends on the maximum degree Δ, but is otherwise independent of the graph. We prove the following approximation guarantee: for any subgraph <i>S</i> with <i>k′</i> vertices and density θ, there exists a set <i>S</i>′ ⊆ <i>S</i> for which the algorithm outputs a subgraph with density Ω(θ/log Δ) whenever <i>v</i> ∈ <i>S</i>′ and <i>k</i> ≥ <i>k</i>′. We prove that <i>S</i>′ contains at least half of the edges in <i>S</i>.
Compliance with age limits for the sales of alcoholic beverages in Romania: Designing and evaluating a three year campaign

The availability of alcohol in general is the most important predictor of alcohol consumption and alcohol abuse in adolescents. Alcohol availability can divided into economic (alcohol prices and discounts), physical (number of alcohol outlets, opening hours), legal (age limits on drinking and purchasing alcohol) and social availability (at home availability, parental behavior and parenting style). When protecting youth from alcohol use, the legal availability is the strongest instrument.Of course, when legislation states that alcohol is not allowed to be sold to people under a certain age, both on-premise (e.g., bars) and off-premise (e.g.,supermarkets) alcohol outlet personnel should be trained and enforced in complying with legal age limits. In order to explore baseline compliance to this legislation a mystery shopping study was conducted in a Romanian city. Under ages and trained students tried to buy alcohol in to explore to what extent alcohol sellers comply with this legal age limits. This compliance level turned out to be 0%. Within the alcohol project, therefore, it was decided to develop a campaign in which the importance of this age limit was communicated. After this campaign, again compliance was measured. Compliance was improved in the on-premise (bars) outlets only. Despite that the results on compliance with the age limit in practice were not strong directly after the campaign, both elements from that intervention and the research method can be used in other Romanian cities to improve and measure compliance with age limits on the sales of alcohol.
Inferring locks for atomic sections

Atomic sections are a recent and popular idiom to support the development of concurrent programs. Updates performed within an atomic section should not be visible to other threads until the atomic section has been executed entirely. Traditionally, atomic sections are supported through the use of optimistic concurrency, either using a transactional memory hardware, or an equivalent software emulation (STM). This paper explores automatically supporting atomic sections using pessimistic concurrency. We present a system that combines compiler and runtime techniques to automatically transform programs written with atomic sections into programs that only use locking primitives. To minimize contention in the transformed programs, our compiler chooses from several lock granularities, using fine-grain locks whenever it is possible. This paper formally presents our framework, shows that our compiler is sound (i.e., it protects all shared locations accessed within atomic sections), and reports experimental results.
Fbxw7 Tumor Suppressor: A Vital Regulator Contributes to Human Tumorigenesis

AbstractRapidly accumulating data indicate that F-box/WD repeat-containing protein 7 (Fbxw7) is one of the most frequently mutated genes in human cancers and regulates a network of crucial oncoproteins. These studies have generated important new insights into tumorigenesis and may soon enable therapies targeting the Fbxw7 pathway.We searched PubMed, Embase, and ISI Web of Science databases (1973–2015, especially recent 5 years) for articles published in the English language using the key words “Fbxw7,” “Fbw7,” “hCDC4,” and “Sel-10,” and we reviewed recent developments in the search for Fbxw7.Fbxw7 coordinates the ubiquitin-dependent proteolysis of several critical cellular regulators, thereby controlling essential processes, such as cell cycle, differentiation, and apoptosis. Fbxw7 contains 3 isoforms (Fbxw7&agr;, Fbxw7&bgr;, and Fbxw7&ggr;), and they are differently regulated in subtract recognition. Besides those, Fbxw7 activity is controlled at different levels, resulting in specific and tunable regulation of the abundance and activity of its substrates in a variety of human solid tumor types, including glioma malignancy, nasopharyngeal carcinoma, osteosarcoma, melanoma as well as colorectal, lung, breast, gastric, liver, pancreatic, renal, prostate, endometrial, and esophageal cancers.Fbxw7 is strongly associated with tumorigenesis, and the mechanisms and consequences of Fbxw7 deregulation in cancers may soon enable the development of novel therapeutic approaches.
STRAIGHT: An image schema and its metaphorical extensions

In this article, Ipropose STRAIGHT äs an image Schema, discuss t he evidence for this claim, and examine the relationship between some of the specific properties of this image Schema in our experience and how they are extended into abstract domains. Relying on Johnson s (1987) criteria for an image Schema, I review research on the special role of straight lines in visual perception, and consider the relations between spatial and forcedynamic properties of straight bodily forms and movements, and of straight objects which we commonly encounter in our experience, particularly in industrialized societies. An examination of metaphorical expressions in English and Russian shows t hat domains in these languages commonly characterized by STRAIGHTNESS— or its opposites—include timef events, discourse, thought, control, social norms, moralityt truth, and law. The examples support findings from previous research that a duality commonly exists in Systems of metaphors between OBJECT and LOCATION versions. Cultural models of the target domains are also discussed äs a factor which motivates the metaphorical charactenzation of a domain äs STRAIGHT or not, and whether that STRAIGHTNESS is evaluated äs positive or negative. Keyword s: image Schema; metaphor; morality; perception; straight. 1. Evidence for STRAIGHT äs an image Schema Since Johnson (1987) presented bis arguments for recognizing a number of image Schemas äs recurrent patterns, shapes, and/or regularities of our actions, perceptions, and conceptions, the bulk of the research ensuing from this study has focussed on the metaphorical extension of image Schemas to abstract domains. Though Johnson (1987: 106) notes that the list of image Schemas he discusses is merely a selection of those he believes Cognitive Linguistics 9-2 (1998), 107-149 0936-5907/98/0009-0107 © Walter de Gruyter
Exploring the effects of cumulative contextual cues on interpreting vibrotactile messages

The sense of touch has been shown to convey emotive information and nuances in face-to-face interpersonal communication, but its applications in mobile communication technologies are still limited. One of the challenges for such new communication medium is the interpretation of tactile messages. This paper presents a study with an early prototype of a mobile tactile device. Twenty novice participants interpreted four messages consisting of a four-channel vibrotactile stimulus, complemented with three cumulative textual cues regarding 1) the communication setting, 2) sender, and 3) situation. The subjective interpretations were assessed with four semantic differential scales, and the reasoning behind the interpretations was inquired by interviewing. The findings show that the intensity and, to some degree, the friendliness of the message could be identified from the tactile-only message. However, to correctly interpret the degree of formality or emotionality in the message, also contextual cues were needed.
The Nitsche conjecture

The Nitsche conjecture is deeply rooted in the theory of doubly connected minimal surfaces. However, it is commonly formulated in slightly greater generality as a question of existence of a harmonic homeomorphism between circular annuli h : A = A(r, R) onto −→ A(r∗, R∗) = A In the early 1960s, while attempting to describe all doubly connected minimal graphs over a given annulus A∗, J.C. C. Nitsche observed that their conformal modulus cannot be too large. Then he conjectured, in terms of isothermal coordinates, even more; A harmonic homeomorphism h : A onto −→ A∗ exists if an only if: R∗ r∗ > 1 2 „ R r + r R « This fascinating and engaging problem remained open for almost a half of a century. In the present paper we provide, among further generalizations, an affirmative answer to his conjecture.
Mouse models for the investigation of MAPT and its role in neurodegenerative disease

Microtubule-associated protein tau plays an important role in many neurodegenerative diseases. By using and creating various novel mouse models, the role of tau and its relationship with other amyloidogenic proteins was investigated. Behavioural and molecular characterization of novel mouse models expressing all six isoforms of human wild-type (H1) or N296H mutant (N51) tau protein was carried out to study the age-related emergence of phenotypes commonly associated with tauopathies. Mutant animals displayed no degenerative cognitive or motor phenotype. However, a possible mood phenotype was observed even at a young age. No formation of intracellular tau inclusions was observed. Using acute slice cultures, I further investigated phosphorylation of N296H mutant tau. Relative tau hypophosphorylation was observed in a N296H mutant compared to the wild-type tau expressing animals. In the hippocampus, exposure to Abeta led to an increase in tau phosphorylation at S202/T205 in H1, but not N51 mice. Electrophysiological studies by M. Vargas-Caballero showed that H1, but not N51 animals are susceptible to Abeta-induced LTP impairment. Taken together, these results suggest that tau phosphorylation could mediate the effects of Abeta on LTP. N51 mice also showed a trend towards increased fyn expression. Fyn relocalization into the soma was not detected either in N51 or tau knockout animals. The functional relationship between tau and α-synuclein was investigated in several novel models. Neither acute exposure of acute slices to α-synuclein oligomers nor α-synuclein overexpression induced tau hyperphosphorylation. A novel mouse model lacking both tau and α-synuclein was generated, but revealed no remarkable behavioural changes. Finally, a new mouse model was created overexpressing human wild-type α-synuclein on a tau knockout background to investigate whether tau is required for α-synuclein-induced dopamine release deficits previously observed in α-synuclein overexpressors.