Miracle-dz/UniFAR-FTUs huggingface dataset:
Meta-Optimization of the Extended Kalman Filter’s Parameters Through the Use of the Bias Variance Equilibrium Point Criterion

The extraction of information on land cover classes using unsupervised methods has always been of relevance to the remote sensing community. In this paper, a novel criterion is proposed, which extracts the inherent information in an unsupervised fashion from a time series. The criterion is used to fit a parametric model to a time series, derive the corresponding covariance matrices of the parameters for the model, and estimate the additive noise on the time series. The proposed criterion uses both spatial and temporal information when estimating the covariance matrices and can be extended to incorporate spectral information. The algorithm used to estimate the parameters for the model is the extended Kalman filter (EKF). An unsupervised search algorithm, specifically designed for this criterion, is proposed in conjunction with the criterion that is used to rapidly and efficiently estimate the variables. The search algorithm attempts to satisfy the criterion by employing density adaptation to the current candidate system. The application in this paper is the use of an EKF to model Moderate Resolution Imaging Spectroradiometer time series with a triply modulated cosine function as the underlying model. The results show that the criterion improved the fit of the triply modulated cosine function by an order of magnitude on the time series over all seven spectral bands when compared with the other methods. The state space variables derived from the EKF are then used for both land cover classification and land cover change detection. The method was evaluated in the Gauteng province of South Africa where it was found to significantly improve on land cover classification and change detection accuracies when compared with other methods.
Flexural stiffness in insect wings I. Scaling and the influence of wing venation

SUMMARY During flight, many insect wings undergo dramatic deformations that are controlled largely by the architecture of the wing. The pattern of supporting veins in wings varies widely among insect orders and families, but the functional significance of phylogenetic trends in wing venation remains unknown, and measurements of the mechanical properties of wings are rare. In this study, we address the relationship between venation pattern and wing flexibility by measuring the flexural stiffness of wings (in both the spanwise and chordwise directions) and quantifying wing venation in 16 insect species from six orders. These measurements show that spanwise flexural stiffness scales strongly with the cube of wing span, whereas chordwise flexural stiffness scales with the square of chord length. Wing size accounts for over 95% of the variability in measured flexural stiffness; the residuals of this relationship are small and uncorrelated with standardized independent contrasts of wing venation characters. In all species tested, spanwise flexural stiffness is 1-2 orders of magnitude larger than chordwise flexural stiffness. A finite element model of an insect wing demonstrates that leading edge veins are crucial in generating this spanwise-chordwise anisotropy.
Do risk factors for suicidal behavior differ by affective disorder polarity?

Background Suicide is a leading cause of death and has been strongly associated with affective disorders. The influence of affective disorder polarity on subsequent suicide attempts or completions and any differential effect of suicide risk factors by polarity were assessed in a prospective cohort. Method Participants with major affective disorders in the National Institute of Mental Health (NIMH) Collaborative Depression Study (CDS) were followed prospectively for up to 25 years. A total of 909 participants meeting prospective diagnostic criteria for major depressive and bipolar disorders were followed through 4204 mood cycles. Suicidal behavior was defined as suicide attempts or completions. Mixed-effects, grouped-time survival analysis assessed risk of suicidal behavior and differential effects of risk factors for suicidal behavior by polarity. In addition to polarity, the main effects of age, gender, hopelessness, married status, prior suicide attempts and active substance abuse were modeled, with mood cycle as the unit of analysis. Results After controlling for age of onset, there were no differences in prior suicide attempts by polarity although bipolar participants had more prior severe attempts. During follow-up, 40 cycles ended in suicide and 384 cycles contained at least one suicide attempt. Age, hopelessness and active substance abuse but not polarity predicted suicidal behavior. The effects of risk factors did not differ by polarity. Conclusions Bipolarity does not independently influence risk of suicidal behavior or alter the influence of well-established suicide risk factors within affective disorders. Suicide risk assessment strategies may continue to appraise these common risk factors without regard to mood polarity.
Depression subtypes and response to phenelzine, diazepam, and a placebo. Results of a nine hospital collaborative study.

A total of 325, newly admitted, depressed patients from nine hospitals were randomly assigned to treatment with either diazepam, phenelzine, or a placebo. The study was conducted double-blind and ran for seven weeks. Median daily dosages were 30 mg of diazepam and 45 mg of phenelzine. The major study finding was the differential effects of diazepam for patients categorized as anxious and hostile depressions. There was a significant number of anxious-depressive patients who were diazepam responders, ie, their symptoms subsided on this treatment and became worse when this drug was discontinued. In contrast, diazepam was a poor treatment for the hostile depressions. These patients were restless, anxious, negativistic, suspicious, and irritable when they entered the study. These symptoms persisted on diazepam and improved on either phenelzine or a placebo.
Breast Cancer Resistance Protein Interacts with Various Compounds in Vitro, but Plays a Minor Role in Substrate Efflux at the Blood-Brain Barrier

Expression of breast cancer resistance protein (Bcrp) at the blood-brain barrier (BBB) has been revealed recently. To investigate comprehensively the potential role of Bcrp at the murine BBB, a chemically diverse set of model compounds (cimetidine, alfuzosin, dipyridamole, and LY2228820) was evaluated using a multiexperimental design. Bcrp1 stably transfected MDCKII cell monolayer transport studies demonstrated that each compound had affinity for Bcrp and that polarized transport by Bcrp was abolished completely by the Bcrp inhibitor chrysin. However, none of the compounds differed in brain uptake between Bcrp wild-type and knockout mice under either an in situ brain perfusion or a 24-h subcutaneous osmotic minipump continuous infusion experimental paradigm. In addition, alfuzosin and dipyridamole were shown to undergo transport by P-glycoprotein (P-gp) in an MDCKII-MDR1 cell monolayer model. Alfuzosin brain uptake was 4-fold higher in mdr1a(–/–) mice than in mdr1a(+/+) mice in in situ and in vivo studies, demonstrating for the first time that it undergoes P-gp-mediated efflux at the BBB. In contrast, P-gp had no effect on dipyridamole brain penetration in situ or in vivo. In fact, in situ BBB permeability of these solutes appeared to be primarily dependent on their lipophilicity in the absence of efflux transport, and in situ brain uptake clearance correlated with the intrinsic transcellular passive permeability from in vitro transport and cellular accumulation studies. In summary, Bcrp mediates in vitro transport of various compounds, but seems to play a minimal role at the BBB in vivo.
INS/GPS Aided by Frequency Contents of Vector Observations With Application to Autonomous Surface Crafts

This paper presents a high-accuracy, multirate inertial navigation system (INS) integrating global positioning system (GPS) measurements and advanced vector aiding techniques for precise position and attitude estimation of autonomous surface crafts (ASCs). Designed to be implemented and tested in the DELFIMx catamaran developed at ISR/IST, the navigation system comprises an advanced inertial integration algorithm to account for coning and sculling motions, combined with an extended Kalman filter (EKF) for inertial sensor error compensation. Aiding gravitational observations are optimally exploited in the EKF, by deriving a sensor integration technique that takes into account the vehicle's dynamics bandwidth information to properly trace measurement disturbances and extract the relevant sensor information. The proposed aiding technique and the performance of the navigation system are assessed using experimental data obtained at seatrials with a low-cost hardware architecture installed on-board the DELFIMx platform. It is shown that the low frequency information embodied in pendular measurements improves the compensation of inertial sensor bias and noise, and consequently enhances the performance of position and attitude estimation. The overall improvements obtained with the vector aiding observations are also illustrated for the case of GPS signal outage, emphasizing the extended autonomy of the navigation system with respect to position aiding.
Multiple stuck-at-fault detection theorem

The paper discusses the problem of testing multiple faults in combinational circuits. A definition of a test group is introduced for easier handling of fault masking. Test pair, as a known concept for proving correctness of a line in the circuit is regarded as a special case of the test group. A theorem is proved that if the test group will pass then a particular sub-circuit can be regarded as fault free at any possible combination of stuck-at-faults (SAF) in the circuit. Unlike the traditional approaches, we do not target the faults as test objectives. The goal is to verify the correctness of a part of the circuit. The whole test sequence is presented as a set of test groups where each group has the goal to identify the correctness of a selected part of a circuit.
Mosquito Fauna in Municipal Parks of São Paulo City, Brazil: A Preliminary Survey

Abstract A mosquito faunal survey was conducted from October 2010 to February 2011 in the municipal parks of São Paulo City, Brazil. A total of 7,015 specimens of 53 taxonomic categories grouped into 12 genera (Aedes, Anopheles, Coquilletidia, Culex, Limatus, Lutzia, Mansonia, Psorophora, Toxorhynchites, Trichoprosopon, Uranotaenia, and Wyeomyia) were collected. The largest and most peripheral parks showed greater species richness compared to smaller and more centralized parks.
NORMATIVE VALUES IN HEALTHY ADULTS FOR THE 6-MINUTE AND 2-MINUTE WALK TESTS IN BELGIUM AND VIETNAM: IMPLICATIONS FOR CLINICAL PRACTICE

Objective To establish reference values for the 6-minute walk test (6MWT) and 2-minute walk test (2MWT) distances, to investigate the correlation between these 2 tests, and to establish prediction equations for these distances in healthy populations of Belgium and Vietnam. Design Cross-sectional study. Subjects and methods The 6MWT and 2MWT were administered to a convenience sample of 239 Belgian and 303 Vietnamese participants between the ages of 18 and 80 years. Results The mean (standard deviation; SD) 2MWT distances were 215 (32.8) m for Belgian participants and 156 (25.5) m for Vietnamese participants. The mean (SD) 6MWT distances were 625 (90.7) m for Belgian participants and 449 (70.4) m for Vietnamese participants. The Pearson correlation coefficient between the 2 tests was 0.901 (p < 0.001) for Belgian participants and 0.871 (p < 0.001) for Vietnamese participants. Age and sex were the 2 most important predictors of walking distance, followed by body mass index for Belgium and height for Vietnam. The adjusted R² ranged from 0.31 to 0.49 across 4 predictive equations. Conclusion These results can be used to determine the presence of walking performance deficits and to guide future studies. The 2MWT is suggested as a useful and convenient alternative to the 6MWT for assessing walking performance in clinical practice. LAY ABSTRACT This study aimed to establish reference values, correlations and prediction equations for the 6-minute walk test and 2-minute walk test in healthy individuals from Belgium and Vietnam. A total of 239 Belgian and 303 Vietnamese volunteers, age range 18–80 years, participated in this cross-sectional study. Results showed that there were differences in the walking distances between the 2 countries, with Belgian participants walking greater distances than Vietnamese participants in both the 2-minute and 6-minute walk tests. A strong correlation was observed between 6-minute walk test and 2-minute walk test distances for both groups. Age and sex were the 2 most important predictors of walking distance, along with body mass index for Belgium and height for Vietnam. These findings provide clinicians with age- and sex-specific reference values to assess walking performance and guide future studies. The 2-minute walk test is suggested as a convenient alternative to the 6-minute walk test for assessing walking performance in clinical practice.
Nonstationary Harmonic Modeling for ECG Removal in Surface EMG Signals

We present a compact approach for mitigating the presence of electrocardiograms (ECG) in surface electromyographic (EMG) signals by means of time-variant harmonic modeling of the cardiac artifact. Heart rate and QRS complex variability, which often account for amplitude and frequency time variations of the ECG, are simultaneously captured by a set of third-order constant-coefficient polynomials modulating a stationary harmonic basis in the analysis window. Such a characterization allows us to significantly suppress ECG from the mixture by preserving most of the EMG signal content at low frequencies (less than 20 Hz). Moreover, the resulting model is linear in parameters and the least-squares solution to the corresponding linear system of equations efficiently provides model parameter estimates. The comparative results suggest that the proposed method outperforms two reference methods in terms of the EMG preservation at low frequencies.
Explaining Social Media Use Reduction As an Adaptive Coping Mechanism: The Roles of Privacy Literacy, Social Media Addiction and Exhaustion

This study integrates privacy calculus and stress-coping theories to understand social media (SM) use reduction. Findings using a survey of 255 SM users show that privacy concerns are a stressor that drives adaptive coping mechanisms and later use reduction. Further, it was demonstrated that the translation of privacy calculus considerations into adaptive coping depends on privacy literacy. Moreover, adaptive coping’s impact on use reduction decreased in users addicted to, but not exhausted by SM use.
Identification of Region-Specific Myocardial Gene Expression Patterns in a Chronic Swine Model of Repaired Tetralogy of Fallot

Surgical repair of Tetralogy of Fallot (TOF) is highly successful but may be complicated in adulthood by arrhythmias, sudden death, and right ventricular or biventricular dysfunction. To better understand the molecular and cellular mechanisms of these delayed cardiac events, a chronic animal model of postoperative TOF was studied using microarrays to perform cardiac transcriptomic studies. The experimental study included 12 piglets (7 rTOF and 5 controls) that underwent surgery at age 2 months and were further studied after 23 (+/- 1) weeks of postoperative recovery. Two distinct regions (endocardium and epicardium) from both ventricles were analyzed. Expression levels from each localization were compared in order to decipher mechanisms and signaling pathways leading to ventricular dysfunction and arrhythmias in surgically repaired TOF. Several genes were confirmed to participate in ventricular remodeling and cardiac failure and some new candidate genes were described. In particular, these data pointed out FRZB as a heart failure marker. Moreover, calcium handling and contractile function genes (SLN, ACTC1, PLCD4, PLCZ), potential arrhythmia-related genes (MYO5B, KCNA5), and cytoskeleton and cellular organization-related genes (XIRP2, COL8A1, KCNA6) were among the most deregulated genes in rTOF ventricles. To our knowledge, this is the first comprehensive report on global gene expression profiling in the heart of a long-term swine model of repaired TOF.
Legislative Malapportionment and the Politicization of Germany's Intergovernmental Transfer System

Legislative bargaining theory suggests that fiscal transfers among member states of a federation are determined to a substantial degree by political representation effects. Malapportionment of the states'population in the legislature is claimed to lead to disproportional benefits of overrepresented states. The article analyzes empirically the determinants of funds in Germany's intergovernmental transfer system. The authors expand previous investigations to include the effects of both the bicameral system in Germany and the postreunification period. Using data for the period from 1970 to 2002, the authors find that malapportionment in the upper house leads to disproportional state shares of per capita transfers. Estimates also indicate that the impact of overrepresentation has somewhat increased over time. Disproportional representation in the lower house does not seem to matter, as the institutional framework of decision making in the lower chamber is not too supportive to constitute a bias towards overrepresented states.
Impact of biochar properties on soil conditions and agricultural sustainability: A review

This review summarizes the influences of pyrolysis conditions and feedstock types on biochar properties and how biochar properties in turn affect soil properties. Mechanistic evidence of biochar's potential for enhancing crop productivity, carbon sequestration, and nutrient use efficiency are also discussed. The review identifies the knowledge gaps, limitations, and future research directions for large‐scale use of biochar. Both pyrolytic parameters and feedstock types are considered to be the main factors controlling biochar properties such as nutrient content, recalcitrance, and pH. Biochar produced at low temperatures may improve nutrient availability and crop yield in acidic and alkaline soils, whereas high‐temperature biochar may enhance long‐term soil carbon sequestration. Biochar can also improve the efficiency of inorganic and organic fertilizers by enhancing microbial functions and reducing nutrient loss, thereby making nutrients more available to plants. Integration of biochar and chemical or organic fertilizers generally provides for better nutrient management and crop yield in most types of soils. Although biochar can improve degraded soils, it is not a panacea; as such, soil‐ and crop‐specific biochar are needed in order to ensure optimum crop yield and agricultural sustainability.
Complexity, emergence and cellular urban models: lessons learned from applying SLEUTH to two Portuguese metropolitan areas

We explore the simulation of urban growth using complex systems theory and cellular automata (CA). The SLEUTH urban CA model was applied to two different metropolitan areas in Portugal, with the purposes of allowing a comparative analysis, of using the past to understand the dynamics of the regions under study, and of learning how to adapt the model to local characteristics in the simulation of future scenarios. Analysis of the two case studies show the importance of SLEUTH's self-modification rules in creating emergent urban forms. This behavior can help build an understanding of urban social systems through this class of CA.
Ebstein’s Anomaly

Ebstein’s anomaly (EA), a rare congenital heart disease, results from the failure of delami- nation of tricuspid valve (TV) leaflets from the endocardium of the right ventricle (RV) and apical displacement, particularly of the septal and posterior leaflets of TV. The most commonly accompanying cardiac malformation is atrial septal defect. Most EA cases are sporadic; familial ones are rare. EA patients may present at any age. Symptoms result from TV regurgitation, RV dysfunction, inadequate left ventricular filling owing to ventricular septal bowing, inadequate pulmonary flow, and arrhythmias. Atrial tachyarrhythmias are the most common late complications. There have been more techniques of tricuspid repair reported in the literature than any other congenital or acquired cardiac lesion. Neonatal operation has a higher risk of mortality than the operations performed beyond infancy. Late survival rate and the quality of life for hospital survivors are excellent.
On the Web at home: Information seeking and Web searching in the home environment

As more people gain at-home access to the Internet, information seeking on the Web has become embedded in everyday life. The objective of this study was to characterize the home as an information use environment and to identify a range of information seeking and Web-search behaviors at home. Twelve Northern California residents were recruited, and the data were collected through semi-structured at-home interviews based on a self-reported Search Activities Diary that subjects kept over a 3-5 day period. The data were analyzed on four levels: home environment, information seeking goals, information retrieval interaction, and search query. Findings indicated that the home, indeed, provided a distinct information use environment beyond physical setting alone in which the subjects used the Web for diverse purposes and interests. Based on the findings, the relationships among home environment, Web context, and interaction situation were identified with respect to user goals and information-seeking behaviors.
Olfactory ensheathing glia injections in Beijing: Misleading patients with ALS

Different forms of cell transplantation therapy are being tested in models of ALS. While the approach offers hope to patients with ALS, much still needs to be learned in the laboratory before it is ready for human trials. Nevertheless, clinics across the world offer various types of open label cell transplantation therapy for high fees. We report a woman who received an injection into each frontal lobe in Beijing, China. Her ALS progressed at a more rapid rate after the procedure and she suffered disabling side‐effects. Clinics that give experimental and potentially harmful treatments outside the construct of well‐designed clinical trials put patients at risk and do a disservice to the ALS community.
Association of Bcl‐2 with Cyclin A/Cdk‐2 Complex and Its Effects on Cdk‐2 Activity

Abstract: In the human endometrial carcinoma cell line HEC1B, the overexpression of Bcl‐2 leads to a G2/M cell cycle arrest. The experiments presented in this work suggest a direct interaction between the antiapoptotic protein Bcl‐2 and the cyclin‐dependent kinase Cdk‐2 and suggest that such interaction is cell cycle dependent. While further experiments are currently under way in our laboratory to elucidate the significance of Cdk‐2/Bcl‐2 complexes in PCD and cell cycle regulation, we demonstrate also a specific inhibitory function of Bcl‐2 on the activity of the coprecipitated kinase.