Miracle-dz/UniFAR-FTUs huggingface dataset:
Cognitive impairment in elderly medical inpatients: detection and associated six-month outcomes.

OBJECTIVE The authors examined the relationship of cognitive impairment at hospital admission to 6-month outcome (hospital readmission, nursing home admission, and death) in a cohort of elderly medical inpatients. METHODS A group of 401 medical inpatients age 75 and older underwent a comprehensive geriatric assessment at hospital admission and were followed up for 6 months. Cognitive impairment was defined as a score <24 on the Mini-Mental State Exam. Detection was assessed through blinded review of discharge summary. Follow-up data were gathered from the centralized billing system (hospital and nursing home admissions) and from proxies (death). RESULTS Cognitive impairment was present in 129 patients (32.3%). Only 48 (37.2%) were detected; these had more severe impairment than undetected cases. During follow-up, cognitive impairment, whether detected or not, was associated with death and nursing home admission. After adjustment for health, functional, and socioeconomic status, an independent association remained only for nursing home admission in subjects with detected impairment. Those with undetected impairment appeared to be at intermediate risk, but this relationship was not statistically significant. CONCLUSION In these elderly medical inpatients, cognitive impairment was frequent, rarely detected, and associated with nursing home admission during follow-up. Although this association was stronger in those with detected impairment, these results support the view that acute hospitalization presents an opportunity to better detect cognitive impairment in elderly patients and target further interventions to prevent adverse outcomes such as nursing home admission.
SpotShare and nearbyPeople: applications of the Social PaL framework

Imagine if there is a privacy-preserving mechanism for two mobile devices to determine if their owners have common friends. It can be useful for access control in applications like ride-sharing, sharing Internet access or even just a simple "people radar" app for showing nearby friends and friends-of-friends. Current mechanisms for doing this come at the cost of revealing these interactions and the users' locations to central servers. In a paper that appears in the WiSec 2015 proceedings, we describe Social Pal [2], a framework that allows privacy-preserving discovery of the distance between two users in a social network. Social Pal was implemented as a general purpose software framework that can be easily used by application developers who wish to incorporate such functionality into their applications.
Speeding-up I/sub DDQ/ measurements

The purpose of this paper is to introduce a new I/sub DDQ/ measurement technique based on active successive approximations, named ASA-I/sub DDQ/. This technique has unique features allowing to speed-up I/sub DDQ/ measurement. Experimental results suggests that a significant speed-up factor can be obtained over the QuiC-Mon technique.
Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.

The E7 proteins encoded by the human papillomaviruses (HPVs) associated with anogenital lesions share significant amino acid sequence homology. The E7 proteins of these different HPVs were assessed for their ability to form complexes with the retinoblastoma tumor suppressor gene product (p105‐RB). Similar to the E7 protein of HPV‐16, the E7 proteins of HPV‐18, HBV‐6b and HPV‐11 were found to associate with p105‐RB in vitro. The E7 proteins of HPV types associated with a high risk of malignant progression (HPV‐16 and HPV‐18) formed complexes with p105‐RB with equal affinities. The E7 proteins encoded by HPV types 6b and 11, which are associated with clinical lesions with a lower risk for progression, bound to p105‐RB with lower affinities. The E7 protein of the bovine papillomavirus type 1 (BPV‐1), which does not share structural similarity in the amino terminal region with the HPV E7 proteins, was unable to form a detectable complex with p105‐RB. The amino acid sequences of the HPV‐16 E7 protein involved in complex formation with p105‐RB in vitro have been mapped. Only a portion of the sequences that are conserved between the HPV E7 proteins and AdE1A were necessary for association with p105‐RB. Furthermore, the HPV‐16 E7‐p105‐RB complex was detected in an HPV‐16‐transformed human keratinocyte cell line.
The Implementation of a Reliable Router Chip by Kin Hong Kan

This thesis describes the implementation of a router chip for a network of processors. The router features the simultaneous bidirection pad drivers and a diagnostic port with a JTAG interface. The design process results in some useful experience for the development of a complex VLSI system in an academic research environment. The router chip is designed for a 3.3v 0.8pm 3 metal layers CMOS process, and is targeted to run at 100MHz. Thesis Supervisor: William J. Dally Title: Associate Professor
Study on temperature distribution at busbar connection based on contact resistance of different plating contact surface

This paper discusses measurement of temperature on busbar connection based on contact resistance and plating material in relation to the value of contact resistance. This study is intended to prevent failure when busbar connection is attached. The failure of the electrical connection can occur due to bad contact so that the contact resistance is increased, high losses, overheating, and it can even cause a fire hazard. Thereare three test samples of modeled: copper busbar connection without plating, copper busbar connection with nickel plating and copper busbar connection with silver plating. The contact resistance of each sample was measured at contact pressure of 12 MPa. Subsequently the samples loaded with the current of 350 A and temperature at the connection was measured and simulated until steady state condition reached. The results show that the temperature at the contact area is higher than that of busbar appears caused by the contact resistance. Both measurement and simulation results show that busbar connection with silver plating having lower contact resistance and lower maximum temperature, followed by the connection with the nickel plating and busbar connection without plating.
Combination of ACF detector and multi-task CNN for hand detection

Hand detection is an important issue in the analysis of drivers activities, assessment of drivers alertness, and subsequent development of driver safety monitoring system. In this work, the hand detection problem is addressed in the deep Convolutional Neural Network (CNN) framework. Hypothesis of hand regions are first generated with high recall rate by AdaBoost detector associated with Aggregated Channel Features (ACF) and then the Convolutional neural networks (CNN) are employed to extract the features of each proposal regions. The CNN was trained via multi-task learning paradigm to detect hand and predict the corresponding bounding box simultaneously. Experiments were conducted on the publically available benchmark VIVA hand detection database, showing marked improvement upon previous works.
Factors Predicting Dropout From the Reasoning and Rehabilitation Program With Mentally Disordered Offenders

Studies evaluating the implementation of cognitive skills programs with mentally disordered offenders (MDOs) have reported high dropout rates, but little is known about the factors associated with treatment noncompletion. The authors analyzed data from the first randomized controlled trial of the Reasoning and Rehabilitation (R&R) program with MDOs to determine predictors of treatment dropout. Patients with psychotic disorders were recruited from medium-secure hospitals in the United Kingdom. Fifty percent of the 44 participants allocated to receive R&R prematurely terminated treatment. Program dropout was significantly predicted by scores on the Clinical and Risk Management scales of the Historical, Clinical, Risk Management—20, Factor 2 scores of the Psychopathy Checklist—Screening Version, antisocial personality disorder (ASPD), psychopathy, and recent violence. Psychopathy, ASPD, and recent violence emerged as the strongest predictors of dropout in multivariate analyses. Strategies to improve treatment retention should be targeted at MDOs who display high levels of impulsivity, poor behavioral controls, and antisocial or psychopathic traits.
A Moderated Mediation Analysis of Suicide Proneness Among Lesbian, Gay, and Bisexual Community Members

Internalized homophobia is common among lesbian, gay, and bisexual (LGB) persons; moreover, it can be associated with suicide proneness, among other mental health concerns. The present paper hypothesized cognitions concerning perceived burdensomeness, but not thwarted belongingness, as mediating pathways of the association of internalized homophobia and suicide proneness in a community sample of LGB persons. Further, prior hate crime victimization experiences, suicide attempt history, level of depressive symptoms, and gender were tested as moderators of the above mediation pathway. Participants consisted of 336 LGB community members from an urban primary care clinic. Results indicated that perceived burdensomeness, but not thwarted belongingness, mediated the relationship between internalized homophobia and suicide proneness Further, the following moderation patterns were observed: both gender (significant for males only) and depressive symptoms (significant for those with mild-to-severe levels of depress.
Unitarian ideals and professional diversity in social work practice—the case of Sweden

Attempts to articulate a common core of social work are numerous as is the claim that there exists a ‘true’ or general social work. This article presents results from research on the organisational settings of Swedish social work. Social work managers in 100 middle sized municipalities have been interviewed by means of an extensive interview manual. Data are analysed using quantitative methods. The results demonstrate that since the 1980s specialisation has become the strongest organisational trend. Functional specialisation (division of child welfare, social assistance and social work with substance abusers) is the standard way of organising social work and in many municipalities specialisation has gone much further. An integrated or generic organisational model, which was the imperative of the 1970s, seems to exist only in the smallest municipalities. Some of the organisational changes can be described as short-lived fashions. Specialisation as such seems, however, to be an institutionalised strategy to solve social problems and as a response to expectations from the environment. These results are discussed against the background of the notion of social work as a coherent profession with an identifiable common core and a mutual arsenal of methods.
MUSE: a model to understand simple English

MUSE is a computer model for natural language processing, based on a semantic memory network like that of Quillian's TLC. MUSE, from a Model to Understand Simple English, processes English sentences of unrestricted content but somewhat restricted format. The model first applies syntactic analysis to eliminate some interpretations and then employs a simplified semantic intersection procedure to find a valid interpretation of the input. While the semantic processing is similar to TLC's, the syntactic component includes the early use of parse trees and special purpose rules. The “relational triple” notation used during interpretation of input is compatible with MUSE's memory structures, allowing direct verification of familiar concepts and the addition of new ones. MUSE also has a repertoire of actions, which range from editing and reporting the contents of its own memory to an indirect form of question answering. Examples are presented to demonstrate how the model interprets text, resolves ambiguities, adds information to memory, generalizes from examples, and performs various actions.
STUDI KINERJA FUNGSI-FUNGSI JARAK DAN SIMILARITAS DALAM CLUSTERING DOKUMEN TEKS BERBAHASA INDONESIA

Clustering dokumen teks banyak diteliti karena peranan pentingnya dalam bidang text-mining dan information retrieval. Dalam algoritma clustering pemilihan fungsi jarak atau fungsi similaritas antar objek menjadi kunci keberhasilan algoritma. Pada fungsi jarak, jarak euclidean paling sering digunakan. Fungsi ini memiliki kelemahan jika digunakan untuk vektor berdimensi sangat tinggi yang menyebabkan kinerja clustering menurun. Alternatif dari fungsi jarak adalah fungsi similaritas, antara lain jaccard, dice, cosine dan pearson. Penelitian ini melakukan kajian tentang unjuk kerja fungsi jarak euclidean dengan empat fungsi similaritas tersebut di atas jika diterapkan untuk melakukan clustering dokumen teks berbahasa Indonesia. Dua pendekatan clustering yang dicobakan adalah pendekatan hierarchi dan partisi. Untuk pendekatan hierachi digunakan teknik aglomeratif dengan 2 metode similaritas cluster yaitu GroupAverage dan CompleteLink. Untuk pendekatan partisi juga dicobakan 2 metode, yaitu Bisecting K-Mean dan Buckshot. Koleksi dokumen yang digunakan 12 koleksi dokumen teks berita, yaitu dengan cacah dokumen 50, 100, 200, 300, 400, 500, 600, 700, 800, 1009, 1270 dan 1370 dokumen. Semua koleksi telah dilakukan clustering secara manual. Kriteria kinerja clustering diukur berdasarkan waktu komputasi dan validitas clustering. Untuk validitas digunakan nilai F-measure, yaitu nilai yang diturunkan dari Recall dan Precision yang mengukur kemampuan algoritma melakukan klasifikasi secara benar. Hasil penelitian menunjukkan bahwa hasil clustering terbaik adalah jika digunakan fungsi Cosine dengan rata-rata F-measure untuk seluruh koleksi 0,9313; sementara yang terburuk adalah jika digunakan fungsi jarak eucledian dengan rata-rata F-measure 0,4668. Secara waktu komputasi fungsi cosine juga memiliki kinerja tercepat dengan rata-rata 12,9 detik sedangkan terjelek adalah pearson dengan rata-rata 58,2 detik.
Murine Leukemia Virus Regulates Alternative Splicing through Sequences Upstream of the 5· Splice Site*

Alternative splicing of the primary transcript plays a key role in retroviral gene expression. In contrast to all known mechanisms that mediate alternative splicing in retroviruses, we found that in murine leukemia virus, distinct elements located upstream of the 5′ splice site either inhibited or activated splicing of the genomic RNA. Detailed analysis of the first untranslated exon showed that the primer binding site (PBS) activates splicing, whereas flanking sequences either downstream or upstream of the PBS are inhibitory. This new function of the PBS was independent of its orientation and primer binding but associated with a particular destabilizing role in a proposed secondary structure. On the contrary, all sequences surrounding the PBS that are involved in stem formation of the first exon were found to suppress splicing. Targeted mutations that destabilized the central stem and compensatory mutations of the counter strand clearly validated the concept that murine leukemia virus attenuates its 5′ splice site by forming an inhibitory stem-loop in its first exon. Importantly, this mode of splice regulation was conserved in a complete proviral clone. Some of the mutants that increase splicing revealed an opposite effect on translation, implying that the first exon also regulates this process. Together, these findings suggest that sequences upstream of the 5′ splice site play an important role in splice regulation of simple retroviruses, directly or indirectly attenuating the efficiency of splicing.
Norming C*-Algebras by C*-Subalgebras

We introduce and investigate the notion of a norming C*-subalgebra of C*-algebra. We characterize when von Neumann algebras norm B(H), and construct various examples of abelian and hyperfinite norming subalgebras. We then apply these results to von Neumann algebra cohomology theory and the bounded projection problem for von Neumann algebras.
Optimally sparse spanners in 3-dimensional Euclidean space

Let <italic>V</italic> be a set of <italic>n</italic> points in 3-dimensional Euclidean space. A subgraph of the complete Euclidean graph is a <italic>t</italic>-spanner if for any <italic>u</italic> and <italic>v</italic> in <italic>V</italic>, the length of the shortest path from <italic>u</italic> to <italic>v</italic> in the spanner is at most <italic>t</italic>times <italic>d(u, v)</italic>. We show that for any <italic>t</italic> > 1, a greedy algorithm produces a <italic>t</italic>-spanner with <italic>O(n)</italic> edges, and total edge weight <italic>O(1). wt(MST)</italic>, where <italic>MST</italic> is a minimum spanning tree of <italic>V</italic>.
Undecidable Decisions: Rationality Limits and Decision-making Heuristics

In this article the theoretic evolution and the empirical-experimental efforts that have led to the affirmation of the bounded/procedural rationality paradigm are discussed. Moreover, the debate on supporters of the “optimization” approach and supporters of the “bounded/procedural rationality” approach is traced, highlighting the irreconcilability of these two approaches and, in retort, a solid defense against a merely “reductionist” attempt of the innovative context of the Simonian theory. Critically going over the debate on decision dynamics, it becomes clear how, due to the uncertain nature of rational processes, it is impossible to establish the decision-making best way. The imperfect character of individual choice is explained by how the decider identifies a solution that appears satisfying in that moment due to cognitive and temporal limits.
Electronic Textiles as Disruptive Designs: Supporting and Challenging Maker Activities in Schools

Electronic textiles are a part of the increasingly popular maker movement that champions existing do-it-yourself activities. As making activities broaden from Maker Faires and fabrication spaces in children's museums, science centers, and community organizations to school classrooms, they provide new opportunities for learning while challenging many current conventions of schooling. In this article, authors Yasmin Kafai, Deborah Fields, and Kristin Searle consider one disruptive area of making: electronic textiles. The authors examine high school students’ experiences making e-textile designs across three workshops that took place over the course of a school year and discuss individual students’ experiences making e-textiles in the context of broader findings regarding themes of transparency, aesthetics, and gender. They also examine the role of e-textiles as both an opportunity for, and challenge in, breaking down traditional barriers to computing.
Lithium Reduces Tau Phosphorylation by Inhibition of Glycogen Synthase Kinase-3*

Lithium is one of the most widely used drugs for treating bipolar (manic-depressive) disorder. Despite its efficacy, the molecular mechanism underlying its action has not been elucidated. One recent study has proposed that lithium inhibits glycogen synthase kinase-3 and thereby affects multiple cellular functions. Because glycogen synthase kinase-3 regulates the phosphorylation of tau (microtubule-binding protein that forms paired helical filaments in neurons of the Alzheimer’s disease brain), we hypothesized that lithium could affect tau phosphorylation by inhibiting glycogen synthase kinase-3. Using cultured human NT2N neurons, we demonstrate that lithium reduces the phosphorylation of tau, enhances the binding of tau to microtubules, and promotes microtubule assembly through direct and reversible inhibition of glycogen synthase kinase-3. These results provide new insights into how lithium mediates its effects in the central nervous system, and these findings could be exploited to develop a novel intervention for Alzheimer’s disease.
Two days on explaining and lecturing

ABSTRACT This paper describes the development, evaluation and underlying rationale of a two-day course on explaining and lecturing which has been used extensively in courses for lecturers. It is argued that since lecturing is the major method of teaching in universities it is important to help lecturers to improve their lecturing as well as to help them to become aware of the strengths and weaknesses of lectures.
Safety, tolerability and pharmacokinetics of a novel phosphodiesterase inhibitor, E6005 ointment, in healthy volunteers and in patients with atopic dermatitis

Abstract Objectives: The purpose of the present studies was to assess the safety, tolerability and pharmacokinetics of topical application of a novel phosphodiesterase inhibitor, E6005, in healthy volunteers and in patients with atopic dermatitis (AD). Methods: In two randomized, investigator-blind, vehicle-controlled studies, we evaluated the topical application of E6005 ointment at concentrations ranging from 0.01% to 0.2% in healthy volunteers (Study 001) and in patients with AD (Study 101). Results: Thirty-six subjects were enrolled in Study 001 and 40 in Study 101. Neither skin irritation nor photosensitization was observed with application of E6005 in Study 001. Four subjects receiving E6005 in Study 001 experienced a treatment-emergent adverse event (application site edema, increased alanine aminotransferase or erythema); three of these subjects discontinued the study. Two subjects receiving E6005 in Study 101 experienced an adverse event (gout or enterocolitis); one discontinued the study. Plasma concentrations of E6005 were below the limit of quantification (1 ng/ml) in both studies. Conclusion: E6005 ointment exhibited acceptable safety and tolerability. Topical application of E6005 ointment resulted in very low systemic exposure to E6005 in healthy volunteers and in patients with AD.
Remarks on a global optimization algorithm for H∞ control [and reply]

Some comments on the correctness of the global optimization algorithms given by Yamada-Hara (Proc. American Contr. Conf. (1995); and IEEE Trans. Automat. Contr. , vol.43 (1998)) are made. In reply, Yamada-Hara argue and give explanations to each of the comments made.
Adaptive control system for quadrotor equiped with robotic arm

This article proposes a new control design of quadrotor with attached 2-DOF robotic arm. Proposed adaptive control law is based on combined application of feedback linearization and consecutive compensator methods. Real time computation of the inertia tensor, center of mass position and the reactive torque generated by the manipulator is used to compensate the mutual influence of the system parts. The usefulness of the method is demonstrated by simulation results of the system with external perturbations in comparison with widespread PD controller.
The interplay of conceptions of accounting and schools of thought in accounting history

Paralleling the advent of different conceptions of accounting in the past two decades or so is the distinction between what are now known as the “traditional” and “new” schools of accounting history research. Viewing accounting as a social practice, as opposed to a mere technical practice, orientates the historical researcher firmly into the arena of the new accounting history, which recognizes the pervasive and enabling characteristics of accounting and gives rise to concerns about studying the implications of accounting change on organizational and social functioning. This literature study examines the interplay of conceptions of accounting with schools of thought in the historical accounting literature. It seeks to enhance an understanding of the underlying connections between the conceptions of accounting embraced by researchers of contemporary accounting and the schools of thought adopted by historical accounting researchers. As the state of play in accounting history research appears to have become a little predictable, certain challenges are identified for accounting historians of the future.