Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of budesonide and surfactant in preterm fetal sheep.

Mechanical ventilation causes lung injury and systemic inflammatory responses in preterm sheep and is associated with bronchopulmonary dysplasia (BPD) in preterm infants. Budesonide added to surfactant decreased BPD by 20% in infants. We wanted to determine the effects of budesonide and surfactant on injury from high tidal volume (VT) ventilation in preterm lambs. Ewes at 125 ± 1 days gestational age had fetal surgery to expose fetal head and chest with placental circulation intact. Lambs were randomized to 1) mechanical ventilation with escalating VT to target 15 ml/kg by 15 min or 2) continuous positive airway pressure (CPAP) of 5 cmH2O. After the 15-min intervention, lambs were given surfactant 100 mg/kg with saline, budesonide 0.25 mg/kg, or budesonide 1 mg/kg. The fetuses were returned to the uterus for 24 h and then delivered and ventilated for 30 min to assess lung function. Budesonide levels were low in lung and plasma. CPAP groups had improved oxygenation, ventilation, and decreased injury markers compared with fetal VT lambs. Budesonide improved ventilation in CPAP lambs. Budesonide decreased lung weights and lung liquid and increased lung compliance and surfactant protein mRNA. Budesonide decreased proinflammatory and acute-phase responses in lung. Airway thickness increased in animals not receiving budesonide. Systemically, budesonide decreased monocyte chemoattractant protein-1 mRNA and preserved glycogen in liver. Results with 0.25 and 1 mg/kg budesonide were similar. We concluded that budesonide with surfactant matured the preterm lung and decreased the liver responses but did not improve lung function after high VT injury in fetal sheep.
Can Pediatric Bispectral Index Sensor Replace Adult Bispectral Index Sensor for Depth of Anesthesia Monitoring?

Sir, We report a 53-year-old male with left partial brachial plexus injury posted for exploration and repair under general anesthesia. He was apparently well few days back when he met with an accident following which he developed weakness of the left upper arm. There was no history of loss of consciousness, seizures, nausea, or vomiting. General anesthesia was induced with fentanyl (2 mcg/kg), propofol (2 mg/kg), and rocuronium (1 mg/kg). The airway was secured with laryngeal mask airway size 3. Total intravenous anesthesia (TIVA) was used for maintenance (Propofol @ 100 mcg/kg/min) keeping in mind intraoperative nerve monitoring. Depth of anesthesia was monitored with adult bispectral index (BIS) sensor, applied to the forehead immediately after induction of anesthesia to avoid the incidence of awareness intraoperatively. The monitor displayed a perfect BIS picture with BIS value of 48 with signal quality index (SQI) of 100% and electromyogram (EMG) of 10 decibel (dB) under TIVA. After getting above values, adult BIS sensor was replaced by pediatric sensor on same site under same anesthetic regimen to find out the difference in BIS values between two if any. This time monitor displayed the same BIS value of 48 with SQI of 80% and EMG of 10 dB. Pediatric sensor displayed same BIS value as an adult sensor, but the quality of electroencephalographic (EEG) signals was found to be slightly less compared to an adult. EMG, however, displayed similar value with both sensors.
Bioresorbable scaffolds in the treatment of coronary artery disease

Drug-eluting stents have reduced the risk of in-stent restenosis and have broadened the application in percutaneous coronary intervention in coronary artery disease. However, the concept of using a permanent metallic endovascular device to restore the patency of a stenotic artery has inherited pitfalls, namely the presence of a foreign body within the artery causing vascular inflammation, late complications such as restenosis and stent thrombosis, and impeding the restoration of the physiologic function of the stented segment. Bioresorbable scaffolds (BRS) were introduced to potentially overcome these limitations, as they provide temporary scaffolding and then disappear, liberating the treated vessel from its cage. Currently, several BRSs are available, undergoing evaluation either in clinical trials or in preclinical settings. The aim of this review is to present the new developments in BRS technology, describe the mechanisms involved in the resorption process, and discuss the potential future prospects of this innovative therapy.
Can interprofessional teamwork reduce patient throughput times? A longitudinal single-centre study of three different triage processes at a Swedish emergency department

Objective To determine the impact on emergency department (ED) throughput times and proportion of patients who leave without being seen by a physician (LWBS) of two triage interventions, where comprehensive nurse-led triage was first replaced by senior physician-led triage and then by interprofessional teamwork. Design Single-centre before-and-after study. Setting Adult ED of a Swedish urban hospital. Participants Patients arriving on weekdays 08:00 to 21:00 during three 1-year periods in the interval May 2012 to November 2015. A total of 185 806 arrivals were included. Interventions Senior physicians replaced triage nurses May 2013 to May 2014. Interprofessional teamwork replaced the triage process on weekdays 08:00 to 21:00 November 2014 to November 2015. Main outcome measures Primary outcomes were the median time to physician (TTP) and the median length of stay (LOS). Secondary outcome was the LWBS rate. Results The crude median LOS was shortest for teamwork, 228 min (95% CI 226.4 to 230.5) compared with 232 min (95% CI 230.8 to 233.9) for nurse-led and 250 min (95% CI 248.5 to 252.6) for physician-led triage. The adjusted LOS for the teamwork period was 16 min shorter than for nurse-led triage and 23 min shorter than for physician-led triage. The median TTP was shortest for physician-led triage, 56 min (95% CI 54.5 to 56.6) compared with 116 min (95% CI 114.4 to 117.5) for nurse-led triage and 74 min (95% CI 72.7 to 74.8) for teamwork. The LWBS rate was 1.9% for nurse-led triage, 1.2% for physician-led triage and 3.2% for teamwork. All outcome measure differences had two-tailed p values<0.01. Conclusions Interprofessional teamwork had the shortest length of stay, a shorter time to physician than nurse-led triage, but a higher LWBS rate. Interprofessional teamwork may be a useful approach to reducing ED throughput times.
In vitro Drug Metabolism Investigation of 7-Ethoxycoumarin in Human, Monkey, Dog and Rat Hepatocytes by High Resolution LC-MS/MS

Background: Recently, it has been an increasing concern on the bioactivation and adverse re-actions associated with consumption of herbal and nature products. 7-Ethoxycoumarin is one of coumarin family compounds, but little information is available regarding its potential reactive metabolites. Method: 7-ethoxylcoumarin was incubated individually with human, monkey, dog and rat hepatocytes for 2 hr, metabolites were detected, identified and characterized using high resolution liquid chromagraphy – tandem mass spectrometry. Results: Twenty-eight metabolites (M1 - M28) were detected and identified. O-deethylation, glucuronida-tion, sulfation, oxygenation, oxidative ring-opening, hydrogenation, glutathionation, dehydrogenation, cysteination, glucosidation, methylation, and hydrolysis were observed. At least sixteen metabolites not reported previously, were newly identified. M1 (O-deethylation, mono-oxygenation and glucuronidation), M3 (O-deethylation and glucuronidation), M5 (hydrolysis and mono-oxygenation), M14 (O-deethylation), M16 (hydrolysis), M22 (oxidative ring-opening and oxygenation) and M27 (mono-oxygenation) exhibited high mass spectrometric responses in human hepatocytes. M3, M5, M8, M13 (mono-oxygenation), M14, M16, M18 (O-deethylation and sulfation), M22 and M27 exhibited high mass spectrometric responses in monkey hepatocytes. M14, M16, M18, M20 (glutathionation and dehy-drogenation) and M27 exhibited high mass spectrometric responses in dog hepatocytes. M1 (O-deethylation, mono-oxygenation and glucuronidation), M3, M5, M13, M14, M16, M17 (cysteination), M18, M20, and M22 exhibited high mass spectrometric responses in rat hepatocytes. Conclusion: Most of new metabolites via oxidative ring-opening and glutathionation were identified. Species differences in metabolism of 7-ethoxylcoumarin in hepatocytes were observed. The analysis of metabolites suggests that 7-ethoxylcoumarin may undergo 3,4-epoxidation responsible for formation of glutathione and its derived cysteine conjugates, carboxylic acid and its glucuronides, glucosides and sul-fate.
The Repetition-Break Plot Structure Makes Effective Television Advertisements

The plot structure in television advertisements can enhance consumers’ brand attitudes and foster increasing consumer and industry recognition. A corpus analysis of contemporary television advertisements shows that advertisements using the repetition-break plot structure are a small percentage of television advertisements but a large percentage of Clio and Effie award–winning advertisements. They are also likely to attain postings and views on YouTube. Three experiments using television advertisements from contemporary brands show that repetition-break advertisements are persuasive, leading to more favorable brand attitudes and greater purchase intentions than similar plot structures and that this effect is attributable in part to the advertisements being more engaging. Thus, a theoretically explainable and generic plot structure yields effective advertisements. The result is a new and flexible tool for marketing professionals to use to generate advertisements, with guidelines for when and why it should and should not be effective.
Monostyrene Intake in Albino Rats: Accumulation in Organs and Effects on Growth Performance and Oxidative Stress

Monostyrene (MS) residuals are daily migrating from different polystyrene shaping containers to our foods. In the present study, the distribution, accumulation and clearness rate of MS in different organs were done by one oral gavage of sub-lethal dose of 500 mg/kg bwt in male albino rates. Following MS in kidney, liver and brain indicated that the highest concentration peak was reached after 3 hr. Meanwhile, the maximum and minimum levels were detected in kidney (190.6 µg/100g) and brain (12.8 µg/100g), respectively. After 3 hr of styrene administration, the same decline rate was observed in the three organs. The clearness and metabolites rates of MS after 7 hr of administration were 93%, 76.9% and 71.1% in kidney, liver and brain, respectively. Further, this study investigated the effects of different MS at doses (0.1, 0.3 and 1.0 mg/kg) on growth performance parameters included weight gain (WG), relative liver weight, food efficiency ratio (FER), protein efficiency ratio (PER) and on oxidative stress biomarker; malondialdehyde (MDA) in the plasma of male and female albino rats after 12 weeks of feeding. All tested MS concentrations showed significant effects (P >0.05) on WG, FER and PER of either male or female rats compared to the control group. All these indices were more pronounced in both male and female that administrated MS at dose of 1.0 mg MS/kg bwt. Only in female, relative liver weight was affected significantly at doses of 0.3 and 1.0 mg/kg bwt of MS. Significant differences (P >0.05) were found among the experimental groups in malondialdehyde concentration in plasma of male and female rats; but not in nonlinear behavior. MDA concentration increased significantly (P >0.05) in female plasma compared to male at all tested doses. Styrene concentration in male liver after three months at oral administration of 1 mg/kg was 1.72 µg/100g. It is concluded that MS at tested levels had affected growth performance parameters and led to increase oxidative stress which could have significant health risks. Kidney is the main organ responsible for MS elimination. More precaution should be addressed to food packaging industry to control and monitor MS release from PS food contact materials.
Accelerated Image Reconstruction for Nonlinear Diffractive Imaging

The problem of reconstructing an object from the measurements of the light it scatters is common in numerous imaging applications. While the most popular formulations of the problem are based on linearizing the object-light relationship, there is an increased interest in considering nonlinear formulations that can account for multiple light scattering. In this paper, we propose an image reconstruction method, called CISOR, for nonlinear diffractive imaging, based on our new variant of fast iterative shrinkage/thresholding algorithm (FISTA) and total variation (TV) regularization. We prove that CISOR reliably converges for our nonconvex optimization problem, and systematically compare our method with other state-of-the-art methods on simulated as well as experimentally measured data.
A Rice Glutamate Receptor–Like Gene Is Critical for the Division and Survival of Individual Cells in the Root Apical Meristem[W]

Glu receptors are known to function as Glu-activated ion channels that mediate mostly excitatory neurotransmission in animals. Glu receptor–like genes have also been reported in higher plants, although their function is largely unknown. We have identified a rice (Oryza sativa) Glu receptor–like gene, designated GLR3.1, in which mutation by T-DNA insertion caused a short-root mutant phenotype. Histology and DNA synthesis analyses revealed that the mutant root meristematic activity is distorted and is accompanied by enhanced programmed cell death. Our results supply genetic evidence that a plant Glu receptor–like gene, rice GLR3.1, is essential for the maintenance of cell division and individual cell survival in the root apical meristem at the early seedling stage.
Associations of the IGF2 gene with growth and meat efficiency in Large White pigs.

The insulin-like growth factor 2 gene (IGF2) has been described in several studies as a candidate gene for meat efficiency in pigs. IGF2 is a member of the growth factors family and has an effect on development of muscle tissue. The effect of IGF2 gene polymorphism on meat efficiency was analysed in a population of 121 Large White pigs. A PCR-based test and RFLP methods were used for detection of genotypes. Allele A, lacking the restriction site, was characterised by the presence of a 0.9-kb fragment. In allele B, the amplimer was cut into a 0.8-kb fragment and some barely detectable fragments. The statistical analysis was carried out according to the General Linear Model procedure. The genotype frequencies observed were: 1.65%, 33.88%, 64.46% for AA, AB and BB genotypes, respectively. There was a significant difference (P < or = 0.05) between the AB and BB genotypes in live weight before the test. A significant association between AB and BB genotypes and body weight before the test was found. No significant difference in other traits of growth and meat efficiency was observed (P > 0.05).
Effect of dietary fat type on intestinal digestibility of fatty acids, fatty acid profiles of breast meat and abdominal fat, and mRNA expression of lipid-related genes in broiler chickens

A group of 240-day-old Ross cockerels were used in a 4-week experiment to assess the effect of the fat type on the intestinal digestibility of fatty acids (FAs), the FA profiles of breast meat and abdominal fat, and the mRNA expression of six hepatic lipid-related genes. Experimental diets were supplemented with rapeseed oil, pork lard or palm oil at 60 g/kg. In the control diet, wheat starch was substituted for the fat source. The highest ileal digestibility of the fat and all FAs (except stearic acid) was observed in chickens fed lard. The content of fat in the breast meat of chickens was not significantly influenced by the fat supplements. The FA profiles of breast meat and abdominal fat reflected the FA composition of the diet. In the meat of chickens fed rapeseed oil, oleic acid was the predominant FA. Palmitic acid was the most abundant FA in the meat of chickens fed lard or palm oil. Oleic acid was the most abundant FA in the abdominal fat of all chickens. The highest mRNA expression of desaturases (Δ5-, Δ6- and Δ9-) was observed in chickens fed palm oil. The mRNA expression of hepatic FA synthase was higher in chickens fed palm oil or lard than in chickens fed rapeseed oil. The expression of HMG-CoA reductase was higher in chickens fed palm oil than in those fed rapeseed oil or lard. It can be concluded that rapeseed oil and lard are better sources of lipids than palm oil. These former two sources contain more digestible fatty acids and provide a lower concentration of SFAs in the meat and fat of chickens.
Media Competition and the Source of Disagreement

We study the competitive provision and endogenous acquisition of political information. Our main result identifies a natural equilibrium channel through which a more competitive market for information increases social disagreement. A critical insight we put forward is that competition among information providers leads to a particular kind of informational specialization: firms provide relatively less information on issues that are of common interest, and relatively more information on issues along which agents’ preferences are more heterogeneous. This enables agents to find information providers that are better aligned with their preferences. While agents become individually better informed, the social value of the information provided in equilibirum decreases, thereby decreasing the probability that the society implements socially optimal policies. JEL Classification Numbers: D72, L15, L82.
Template-Based Estimation of Time-Varying Tempo

We present a novel approach to automatic estimation of tempo over time. This method aims at detecting tempo at the tactus level for percussive and nonpercussive audio. The front-end of our system is based on a proposed reassigned spectral energy flux for the detection of musical events. The dominant periodicities of this flux are estimated by a proposed combination of discrete Fourier transform and frequency-mapped autocorrelation function. The most likely meter, beat, and tatum over time are then estimated jointly using proposed meter/beat subdivision templates and a Viterbi decoding algorithm. The performances of our system have been evaluated on four different test sets among which three were used during the ISMIR 2004 tempo induction contest. The performances obtained are close to the best results of this contest.
Frame Instance Extraction and Clustering for Default Knowledge Building

Obtaining and representing common-sense knowledge, useful in a robotics scenario for planning and making inference about the robots’ surroundings, is a challenging problem, because such knowledge is typically found in unstructured repositories such as text corpora or small handmade resources. The work described in this paper presents a methodology for automatically creating a default knowledge base about real-world objects for the robotics domain. The proposed method relies on clustering frame instances extracted from natural language text as a way of distilling default knowledge. We collect and parse a natural language corpus using the Web as a source, then perform an agglomerative clustering of frame instances according to an appropriately defined similarity measure, and finally extract prototypical frame instances from each cluster and publish them in LOD-complaint format to promote reuse and interoperability.
An improved feature selection algorithm based on MAHALANOBIS distance for Network Intrusion Detection

Network Intrusion Detection System (NIDS) plays an important role in providing network security. Efficient NIDS can be developed by defining a proper rule set for classifying network audit data into normal or attack patterns. Generally, each dataset is characterized by a large set of features, but not all features will be relevant or fully contribute identifying an attack. Since different attacks need different subsets to have better detection accuracy, this paper describes an improved feature selection algorithm to identify most appropriate subset of features for a certain attack. The proposed method is based on MAHALANOBIS Distance feature ranking and an improved exhaustive search to choose a better combination of features. We evaluate the approach on the KDD CUP 1999 datasets using SVM classifier and KNN classifier. The results show that classification is done with high classification rate and low misclassification rate with the reduced feature subsets.
Visual predation by the euphausiid Meganyctiphanes norvegica

Experiments showed that Meganyctiphanes nor- vegica are visual predators on copepods. Adult M. norvegica were offered a mixture of equal numbers of late stage Calanus spp. and Metridia longa in total darkness and at a light intensity corresponding to their daytime habitat. Preda- tion rates were 3 times higher in the illuminated containers than in the dark ones (7 vs 2.3 copepods krill -1 18h -1 ), and higher on M. longa than on Calanus spp. in both light (1.3 times) and darkness (2.3 times). Swimming speeds of M. longa were about 10 times faster than those of Calanus spp. , making M. longa more susceptible to mechanical detection.
Epileptiform activity during inert gas euthanasia of mice

Carbon dioxide (CO2) is one of the most commonly used euthanasia agents for mice, yet it is highly aversive and nociceptive. Inert gases are a possible alternative, however there are qualitative reports of seizures resulting from exposure. Here we evaluate epileptiform activity caused by inert gases (N2, He, Ar and Xe) and CO2 in mice chronically instrumented for EEG/EMG undergoing single-gas euthanasia. We found that N2, He and Ar caused epileptiform activity in all animals, CO2 in half of animals and no epileptiform activity produced by Xe. Atmospheric O2 concentrations at epileptiform activity onset were significantly higher for CO2 than for all other gases and occurred soon after loss of motion, whereas N2 and Ar epileptiform activity occurred at cessation of neocortical activity. Helium caused the longest epileptiform activity and these commenced significantly before isoelectric EEG. We did not detect any epileptiform activity during active behaviour. Taken together, these results demonstrate that whilst epileptiform activity from inert gases and particularly Ar and N2 are more prevalent than for CO2, their occurrence at the onset of an isoelectric EEG is unlikely to impact on the welfare of the animal. Epileptiform activity from these gases should not preclude them from further investigation as euthanasia agents. The genesis of epileptiform activity from CO2 is unlikely to result from hypoxia as with the inert gases. Helium caused epileptiform activity before cessation of neocortical activity and for a longer duration and is therefore less suitable as an alternative to CO2.
‘Written in these scars are the stories I can’t explain’: A content analysis of pro-ana and thinspiration image sharing on Instagram

Since pro-anorexia websites began to appear in the 1990s, there has been a growing body of academic work on pro-ana and thinspiration communities online. Underpinned by a range of (inter)disciplinary perspectives, most of this work focuses on websites and blogs. There is a dearth of research and, in particular, gender-aware research on pro-ana practices and discourses in the context of newer mobile social platforms such as Instagram. Using a dataset of 7560 images, this study employs content analysis to ask whether, to what extent and how pro-ana identities and discourses manifest themselves on a more open, image-based platform such as Instagram. We demonstrate that, by mainstreaming pro-ana, Instagram has rendered visible pro-ana sensibilities such as abstinence and self-discipline in the broader context of distressed girls’ lives and Western culture more generally. We conclude that this increased visibility may in fact be a positive development.