Miracle-dz/UniFAR-FTUs huggingface dataset:
The effect of visible light on the carcinogenicity of ultraviolet light.

Summary 1.Swiss mice were exposed to the total energy of quartz mercury vapor Uviarc lamps and subsequently maintained in either the dark or in the white light (fluorescent lamps) to determine if photo-reactivation of ultraviolet carcinogenesis occurred. 2.Less ultraviolet energy was required to produce tumors in the mice housed under white light than in those housed in the dark, which observation indicated an activation by white light of ultraviolet carcinogenesis. From all evidence it would appear doubtful that the very small ultraviolet emission from the fluorescent lights contributed to this higher tumor incidence. 3.Animals exposed to the total ultraviolet energy and simultaneously exposed to visible white light appeared to be protected to a slight degree from the ultraviolet rays. More energy was required to produce tumors in 50 per cent of these animals than was required to produce the same tumor incidence in mice exposed to ultraviolet light alone.
Investigating the impacts of field‐realistic exposure to a neonicotinoid pesticide on bumblebee foraging, homing ability and colony growth

Summary The ability to forage and return home is essential to the success of bees as both foragers and pollinators. Pesticide exposure may cause behavioural changes that interfere with these processes, with consequences for colony persistence and delivery of pollination services. We investigated the impact of chronic exposure (5–43 days) to field‐realistic levels of a neonicotinoid insecticide (2·4 ppb thiamethoxam) on foraging ability, homing success and colony size using radio frequency identification (RFID) technology in free‐flying bumblebee colonies. Individual foragers from pesticide‐exposed colonies carried out longer foraging bouts than untreated controls (68 vs. 55 min). Pesticide‐exposed bees also brought back pollen less frequently than controls indicating reduced foraging performance. A higher proportion of bees from pesticide‐exposed colonies returned when released 1 km from their nests; this is potentially related to increased orientation experience during longer foraging bouts. We measured no impact of pesticide exposure on homing ability for bees released from 2 km, or when data were analysed overall. Despite a trend for control colonies to produce more new workers earlier, we found no overall impacts of pesticide exposure on whole colony size. Synthesis and applications. This study shows that field‐realistic neonicotinoid exposure can have impacts on both foraging ability and homing success of bumblebees, with implications for the success of bumblebee colonies in agricultural landscapes and their ability to deliver crucial pollination services. Pesticide risk assessments should include bee species other than honeybees and assess a range of behaviours to elucidate the impact of sublethal effects. This has relevance for reviews of neonicotinoid risk assessment and usage policy world‐wide.
Mobile robot localization using ceiling landmarks and images captured from an RGB-D camera

In this work we propose two techniques for mobile robot localization for the indoor environment. First, we use the images of the markers attached on the ceiling with known positions to calculate the location and orientation of the robot, like a global method. Second, an RGB-D camera mounted on the robot is adopted to acquire the color and depth images of the environment, like a local method. The relative robot motion is then computed based on the registration of 3D point clouds and SURF features between the consecutive image frames. Since the uncorrelated sensing information is used by the above techniques, we have combined these two approaches to increase the robustness and accuracy of the localization. Experimental results and performance analysis are presented using real world image sequences.
Safety and tolerability of tafluprost in treatment of elevated intraocular pressure in open-angle glaucoma and ocular hypertension

Glaucoma is one of the most common neuropathies of the optic nerve. An elevated intraocular pressure (IOP) is a well documented risk factor for the development and progression of this disease. Until now, IOP reduction is the only well documented successful method of glaucoma treatment. Among the many hypotensive drugs, prostaglandin analogs are proved to be the most potent antiglaucoma agents, with very few systemic side effects. A new prostanoid FP receptor analog, tafluprost, has been introduced into the medical treatment of glaucoma and ocular hypertension. Many studies have shown that it is an efficient IOP-lowering drug, and that it is safe and well tolerated. A preservative-free tafluprost formulation is as potent as a preserved one, but it has fewer and milder toxic effects on the eye.
Automatic FIR Filter Design Method and Tool based on Genetic Algorithms

A FIR Filter design method and its respective tool using genetic algorithms were developed. The main feature of this method is to offer a transparent mode for the user who doesn't know evolutionary computation, as well as its parameters. The user inputs the filter specifications and gets a sub-optimal result in an average number of four attempts. The sub-optimal criterion was based on the Rabiner, Parks and McClellan algorithm and the implemented software was built using the GALOPPS tool
Effect of the probiotic Lactobacilli reuteri (Prodentis) in the management of periodontal disease: a preliminary randomized clinical trial

Abstract Objectives: The aim of this study was to evaluate the effects of Lactobacilli reuteri (Prodentis) alone and in combination with scaling and root planing (SRP) in a double blind, randomized, placebo-controlled clinical trial of volunteers with chronic periodontitis. Methods: Thirty, otherwise systemically healthy, chronic periodontitis patients (19 males and 11 females, aged between 34 and 50 years) were included. The study period was 42 days. ‘Split-mouth’ design was used for the SRP, which was performed on day 0; two quadrants (either right or left) were treated with SRP whereas the remaining two quadrants were left untreated. The participants received a toothbrush, toothpaste, and brushing instructions. L. reuteri Prodentis lozenges (1×108 CFU DSM17938 + 1×108 CFU ATCC PTA 5289) or the corresponding placebo lozenges were taken twice daily from day 21 to day 42. Statistical analysis was done for comparisons of clinical parameters (Plaque Index (PI), Gingival Index (GI), Gingival Bleeding Index (GBI), probing pocket depth (PPD), clinical attachment level (CAL)) and microbiological levels of the pathogens Aggregibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), and Prevotella intermedia (Pi). All p-values less than 0.05 were considered significant. Assessments were made on day 0 before SRP treatment, on day 21 before administration of the lozenges, and on day 42. Results: At day 42, the PI, GI, and GBI were significantly reduced by all treatment modalities. When ranked, the amount of PI, GI and GBI reduction by the different treatments was SRP + Prodentis > Prodentis > SRP + placebo > placebo; all differences were statistically significant. For PPD and CAL, the best result was obtained with the SRP + Prodentis treatment. PPD was reduced from 5.08±0.75 to 3.78±0.61 mm (p<0.001) and CAL from 3.93±0.93 to 2.85±0.74 mm (p<0.001). Prodentis, either alone or following SRP, reduced Aa, Pi, and Pg by 1 log10 unit (p<0.01). The SRP + placebo combination did not significantly affect the levels of the pathogens. Conclusion: The present randomized controlled trial confirms the plaque inhibition, anti-inflammatory, and antimicrobial effects of L. reuteri Prodentis. L. reuteri Prodentis probiotic can be recommended during non-surgical therapy and the maintenance phase of periodontal treatment. Considering the beneficial effects of probiotics, this therapy could serve as a useful adjunct or alternative to periodontal treatment when SRP might be contraindicated. Further studies are required in this direction.
Conservation criminology and the global trade in electronic waste: Applying a multi-disciplinary research framework

The global trade in electronic waste destined for recycling, disposal or reuse (E-waste) poses a significant risk to human health and the natural environment from improper recycling and disposal. However, in part due to the lack of regulatory attention, few empirical studies of this issue exist. In this paper, we fill this knowledge gap by applying a conservation criminology framework to E-waste. Specifically, we draw on criminology and criminal justice, natural-resources management, and risk and decision sciences to describe the nature of the trade, relevant stakeholders, and current interventions. Our initial step is to develop a more holistic picture of E-waste and identify knowledge gaps for future research, working toward building theoretical explanations necessary for effective policy development. Through this work, we hope to demonstrate the importance of, and the steps involved in, using this multi-disciplinary framework to examine and address complex environmental and social problems.
CEREBRAL CIRCULATION: XLV. VASODILATION IN THE PIA FOLLOWING STIMULATION OF THE GENICULATE GANGLION

In a previous paper 1 it was shown that dilation of arteries in the pia following stimulation of certain "depressor" nerves was due to the fall in blood pressure and retarded blood flow through the brain brought about by the stimulation. There still remained the possibility that true dilator fibers might reach the pial arteries by some pathway other than that of the vagus and "depressor" nerves. Such a route had been indicated by the physiologic work of Penfield and of Cobb and Finesinger 2 and the anatomic work of Chorobski and Penfield. 3 A nerve pathway was traced by the last-mentioned authors (in monkeys) from the facial nerve through the geniculate ganglion to the great superficial petrosal nerve and thence to the internal carotid nerve. Stimulation of the facial nerve near its exit from the medulla (after section of the nerve proximally) or stimulation of the superficial petrosal nerve
Self Ratings of Dependency/Addiction Regarding Drugs, Sex, Love, and Food: Male and Female College Students

To what degree do addictions to drugs, sex, love, and food correlate with each other? Are there meaningful sex differences in the addictions? To study this, 9,313 college students (3,083 males, 6,230 females) rated 13 items on 0–100 scales for their dependency/addiction to the things represented by the items. Results indicated that males reported significantly more addictions than females, but females were more likely than males to report addictions for cigarettes, chocolate, and food in general. Results also showed consistent intercorrelations, typically in the 0.20's or 0.30's, but sometimes higher. Not only did things correlate within their category—e.g., the different drugs correlated with each other, indicating polydrug use—but correlations occurred between unrelated topics, such as dependency/addiction to alcohol correlating with dependency/addiction to having sex. The findings support the notion of small but significant overlap in the various dependencies/addictions, and of sex differences in the various addictions.
Effects of chin advancement surgery in hyoid bone and tongue positions and in the dimension of the oropharynx.

INTRODUCTION Advancement genioplasty has been increasingly indicated for the correction of anterior mandibular deficiency as it balances the patient's profile and generates functional changes. OBJECTIVE Thus, the aim of this study was to assess the effects of advancement genioplasty in the oropharyngeal size and in the position of the hyoid bone and tongue. METHODS The sample comprised 22 lateral cephalometric radiographs of 11 individuals who had undergone advancement genioplasty alone. Eleven of these radiographs depicted the immediate preoperative period (T0) and the other 11 the postoperative period after at least four months (T1). The radiographs were scanned and exported to the Radiocef Studio 2.0® software (Radio Memory Ltda., Belo Horizonte, MG, Brazil). The landmarks were then identified and automatically measured by the program. RESULTS The results showed statistically significant differences between the horizontal position of the hyoid bone and tongue and in the oropharyngeal size. The hyoid bone and tongue were repositioned anteriorly after surgery (p = 0.01), thereby increasing the dimension of the oropharyngeal airspace (p = 0.01). CONCLUSIONS The oropharyngeal dimension increased as the tongue base and hyoid bone were repositioned more anteriorly.
CCR 20th Anniversary Commentary: Chimeric Antigen Receptors—From Model T to the Tesla

The research article by Kershaw and colleagues, published in the October 15, 2006, issue of Clinical Cancer Research, presents one of the first clinical trials to utilize chimeric antigen receptors. Subsequent studies have shown promise for the treatment of patients with lymphoid malignancies, but further progress will require optimization, including the identification of more specific antigens for solid tumors. Clin Cancer Res; 21(14); 3099–101. ©2015 AACR. See related article by Kershaw et al., Clin Cancer Res 2006;12(20) Oct 15, 2006;6106–15
How topoisomerase IV can efficiently unknot and decatenate negatively supercoiled DNA molecules without causing their torsional relaxation

Abstract Freshly replicated DNA molecules initially form multiply interlinked right-handed catenanes. In bacteria, these catenated molecules become supercoiled by DNA gyrase before they undergo a complete decatenation by topoisomerase IV (Topo IV). Topo IV is also involved in the unknotting of supercoiled DNA molecules. Using Metropolis Monte Carlo simulations, we investigate the shapes of supercoiled DNA molecules that are either knotted or catenated. We are especially interested in understanding how Topo IV can unknot right-handed knots and decatenate right-handed catenanes without acting on right-handed plectonemes in negatively supercoiled DNA molecules. To this end, we investigate how the topological consequences of intersegmental passages depend on the geometry of the DNA-DNA juxtapositions at which these passages occur. We observe that there are interesting differences between the geometries of DNA-DNA juxtapositions in the interwound portions and in the knotted or catenated portions of the studied molecules. In particular, in negatively supercoiled, multiply interlinked, right-handed catenanes, we detect specific regions where DNA segments belonging to two freshly replicated sister DNA molecules form left-handed crossings. We propose that, due to its geometrical preference to act on left-handed crossings, Topo IV can specifically unknot supercoiled DNA, as well as decatenate postreplicative catenanes, without causing their torsional relaxation.
Mutual Inductance Analysis of Planar Coils with Misalignment for Wireless Power Transfer Systems in Electric Vehicle

This paper presents an analytical approach for calculating the magnetic field distribution excited by planar spiral circular coil and square coil for wireless power transfer (WPT) system. Based on Biot-Savart principle, the spatial magnetic flux density can be computed and the mutual inductance of the coils is calculated by numerical integrals with all possible variations of misalignments. The analytical calculation results are validated by finite element analysis. At last, comparison of the computed mutual inductance between the circular coil and the square coil is elaborated.
Association between Performance Score on Aptitude Tests and Speed of Execution

The relationship between the speed of execution and the ability of a subject when performing mental tasks is a longtime concern of psychometric researchers. However, this relationship is not well documented because execution speed has been measured inaccurately in the past. The relationship between speed of execution and intellectual ability is evaluated here while using subtests from a French Canadian computerized battery of aptitude tests, the Tests d'aptitudes informatisés pour enfants, which adequately provide control of the response time for each presented item. The speed of execution indices we examined here are calculated from the easiest items of six subtests. Those indices are compared with the scores on these subtests as well as with other indices of intellectual ability. The sample comprises 148 children whose average age was 10 years. Analysis suggests that high speed and high scores are related for some types of mental work.
Near-Infrared Photometry of the Star Clusters in the Dwarf Irregular Galaxy IC 5152

We present JHK-band near-infrared photometry of star clusters in the dwarf irregular galaxy IC 5152. After excluding possible foreground stars, a number of candidate star clusters are identified in the near-infrared images of IC 5152, which include young populations. Especially, five young star clusters are identified in the (J-H, H-K) two color diagram and the total extinction values toward these clusters are estimated to be A_V =2 - 6 from the comparison with the theoretical values given by the Leitherer et al. (1999)'s theoretical star cluster model.
Do voice hearers naturally use focusing and metacognitive coping techniques?

Little is known about the types of coping strategies activated by clients suffering from distressing hallucinatory voices and even less about models of coping. This study categorises those coping approaches as distraction, focusing or metacognitive and reports on their frequency in a community sample of voice hearers using thematic analysis. A non-engagement style was found to be predominant and this was linked to coping by distraction and the use of safety behaviours. This study suggests that coping strategies naturally utilised by voice hearers tend to be of limited benefit and may perpetuate the voice hearing experience. It is suggested that hearing voices groups, mental health and CBT training programmes need to stress the importance of voice hearers moving towards focusing and metacognitive styles of coping.
Diet, Inflammation, and Glycemic Control in Type 2 Diabetes: An Integrative Review of the Literature

Type 2 diabetes (T2D) is a growing national health problem affecting 35% of adults ≥20 years of age in the United States. Recently, diabetes has been categorized as an inflammatory disease, sharing many of the adverse outcomes as those reported from cardiovascular disease. Medical nutrition therapy is recommended for the treatment of diabetes; however, these recommendations have not been updated to target the inflammatory component, which can be affected by diet and lifestyle. To assess the current state of evidence for which dietary programs contain the most anti-inflammatory and glycemic control properties for patients with T2D, we conducted an integrative review of the literature. A comprehensive search of the PubMed, CINAHL, Scopus, and Web of Science databases from January 2000 to May 2012 yielded 786 articles. The final 16 studies met the selection criteria including randomized control trials, quasiexperimental, or cross-sectional studies that compared varying diets and measured inflammatory markers. The Mediterranean and DASH diets along with several low-fat diets were associated with lower inflammatory markers. The Mediterranean diet demonstrated the most clinically significant reduction in glycosylated hemoglobin (HbA1c). Information on best dietary guidelines for inflammation and glycemic control in individuals with T2D is lacking. Continued research is warranted.
Adaptivity in Entity Subscription Services

Real-word entities can be mapped to unique entity identifiers through an Entity Name System (ENS), to systematically support the re-use of these identifiers and disambiguate references to real world entities in the Web. An entity subscription service informs subscribed users of changes in the descriptive data of an entity, which is a set of attribute name-value pairs. We study the design, implementation and application of an adaptable push-policy subscription service, within a large-scale ENS. The subscription system aims to deliver ranked descriptions of the changes on entities, following user preferences through a feedback-driven adaptation process. The adaptation is based on both the content and the type of each entity change. We evaluate the learning curve of the system and the utility of the content-type discrimination. The experiments demonstrate good results, especially in the system's content-aware adaptation aspect.
Association Between Physical Activity and Sleep in Adults With Chronic Pain: A Momentary, Within-Person Perspective

Background Individuals with chronic pain consider improved sleep to be one of the most important outcomes of treatment. Physical activity has been shown to have beneficial effects on sleep in the general population. Despite these findings, the physical activity–sleep relationship has not been directly examined in a sample of people with chronic pain. Objective This study aimed to examine the association between objective daytime physical activity and subsequent objective sleep for individuals with chronic pain while controlling for pain and psychosocial variables. Design An observational, prospective, within-person study design was used. Methods A clinical sample of 50 adults with chronic pain was recruited. Participation involved completing a demographic questionnaire followed by 5 days of data collection. Over this period, participants wore a triaxial accelerometer to monitor their daytime activity and sleep. Participants also carried a handheld computer that administered a questionnaire measuring pain, mood, catastrophizing, and stress 6 times throughout the day. Results The results demonstrated that higher fluctuations in daytime activity significantly predicted shorter sleep duration. Furthermore, higher mean daytime activity levels and a greater number of pain sites contributed significantly to the prediction of longer periods of wakefulness at night. Limitations The small sample size used in this study limits the generalizability of the findings. Missing data may have led to overestimations or underestimations of effect sizes, and additional factors that may be associated with sleep (eg, medication usage, environmental factors) were not measured. Conclusions The results of this study suggest that engagement in high-intensity activity and high fluctuations in activity are associated with poorer sleep at night; hence, activity modulation may be a key treatment strategy to address sleep complaints in individuals with chronic pain.
Optimal Quality of Service Control in Communication Systems

Na afloop van de plechtigheid is er een receptie, waarvoor u ook van harte bent uitgenodigd. In current practice, quality of composite services is usually controlled on an ad-hoc basis, while the consequences of failures in service chains are often not well understood. A main concern is that, although such an approach might work for small chains, it will become unfeasible for future complex global-scale service chains. This raises the need for mechanisms that enable efficient usage of available shared resources while preserving the desired Quality of Service (QoS) as perceived by the end user.
Social Justice Education for Preservice Leaders: Evaluating Transformative Learning Strategies

Abstract The purpose of this article is to explore the effects of an alternative, transformative pedagogy that may assist us in responding to the urgent call for changes in the way educational leaders are prepared and developed. Within the contextual loom of preparation programs, the two theoretical perspectives of Transformative Learning Theory and Critical Social Theory are interwoven with the three pedagogical strategies of critical reflection, rational discourse, and policy praxis to increase students' awareness, acknowledgment, and action regarding issues of social justice and equity.