Miracle-dz/UniFAR-FTUs huggingface dataset:
28-Day Repeated Oral Toxicity Study and Efficacy of a Siddha Polyherbal Formulation - Singinatha Choornam against Platelet Activating Factor-induced Rhinosinusitis in Wistar Albino Rat

Singinatha choornam is an oral polyherbal formulation used in the treatment of allergic rhinosinusitis cited in Siddha literature Agathiar Attavanai Vagadam. This study aimed to validate Singinatha choornam as an effective drug against platelet activating factor-induced rhinosinusitis in rat model. Safety study for Singinatha choornam was done by treating rats orally with 18, 90 and 180 mg/kg b.wt. /p.o. /day for 28 days following OECD 407 guidelines. No mortality, abnormal signs and symptoms, significant haematological, biochemical and histopathological variations were observed. A phospholipid inflammatory mediator, 50 µl were applied intranasally in rats of test and standard groups while control groups intranasally treated with 50 µl of distilled water as single application. Three groups of rat were allotted (control - distilled water 2 ml/dose, test drug - Singinatha choornam 90 mg/kg and standard - chloropheniramine maleate 1 mg/kg) and treated for 3 days. After end of the study, rats were sacrificed and examined for nasal sinuses and lamina propria histology. The count of neutrophils was reduced significantly in test group compared with control along absence of eosinophil. The study concludes Singinatha choornam has efficacy against rhinosinusitis in rat model but not so significant to standard treatment.
Audiovisual three-level fusion for continuous estimation of Russell's emotion circumplex

Predicting human emotions is catching the attention of many research areas, which demand accurate predictions in uncontrolled scenarios. Despite this attractiveness, designed systems for emotion detection are far off being as accurate as desired. Two of the typical measurements in human emotions are described in terms of the dimensions valence and arousal, which shape the Russell's circumplex where complex emotions lie. Thus, the Affect Recognition Sub-Challenge (ASC) of the third AudioVisual Emotion and Depression Challenge, AVEC'13, is focused on estimating these two dimensions. This paper presents a three-level fusion system combining single regression results from audio and visual features, in order to maximize the mean average correlation on both dimensions. Five sets of features are extracted (three for audio and two for video), and they are merged following an iterative process. Results show how this fusion outperforms the baseline method for the challenge database.
Response of cloned progeny of clinical isolates of herpes simplex virus to human leukocyte interferon

First- and third-generation cloned progeny viruses were derived from clinical isolates of herpes simplex virus and examined for their sensitivities to human interferon by inhibition of plaque formation in Vero cells. The dose-response curves obtained with the first- and third-generation clones were similar to those obtained with the parental isolates, and both the parent and the clones showed similar sensitivities to interferon. These results suggest that clinical isolates of herpes simplex virus consist of a homogeneous population of virus particles with respect to interferon sensitivity. The dose-response curves obtained with herpes simplex virus demonstrated a shallower slope than those obtained with vesicular stomatitis virus. Vesicular stomatitis virus plaque formation as completely inhibited at high concentrations of interferon, whereas complete inhibition of plaque formation by herpes simplex virus did not occur at the highest concentration of interferon used. Cloned progeny were derived from plaques appearing in the presence of high concentrations of interferon. The dose-response curves and interferon sensitivities of these clones were similar to those of the parent and third-generation clone from which they were derived. There was no evidence for genetic heterogeneity with respect to interferon sensitivity.
Output consensus for networks of non-identical introspective agents

In this paper, we consider three problems, namely, the output consensus problem, the model-reference output consensus problem, and the regulation of output consensus problem, for a network of non-identical right-invertible linear agents. The network provides each agent with a linear combination of multiple agents' outputs. We assume that all the agents are introspective, meaning that they have access to their own local measurements. Under this assumption, we then propose a distributed linear protocol to solve each problem for a broad class of network topologies, including not only Laplacian topologies for a directed graph which contains a directed spanning tree, but a wide family of asymmetric topologies.
Diagnostic efficacy of the leukogram and the chemiluminometric ACTH measurement to diagnose canine hypoadrenocorticism

Summary Background and objective: The gold standard in the diagnosis of canine hypoadrenocorticism (HA) is the adrenocorticotropin (ACTH) response test. As synthetic ACTH (tetracosactide [Synacthen®]) is currently not available in the European Union, the evaluation of other diagnostic tests seemed warranted. The diagnostic efficacy of electrolytes, the leukogram and endogenous ACTH concentrations to diagnose HA was investigated. Material and methods: The medical records of 145 dogs with clinical signs suspect for spontaneous HA were included in a retrospective study. HA was diagnosed (n = 38) or ruled out (n = 84) by using an ACTH response test. In 23 patients HA was excluded by basal cortisol measurement. The diagnostic performance of various variables was assessed based on receiver operating characteristic (ROC) curves and by calculating differential positive rates. A decision tree (IBM SPSS Decision Trees 20, IBM Corporation) was constructed with the variables neutrophil to lymphocyte ratio (N/LR) and sodium to potassium ratio (Na/KR) to illustrate the diagnostic efficacy of the respective test results. Results: The best single variables to diagnose HA were the endogenous ACTH concentration (area under the ROC curve [ROC AUC] 0.97; cutoff > 50 pmol/l: sensitivity 96%, specificity 100%) and the Na/KR (ROC AUC 0.905; cutoff ≤ 22: sensitivity 92%, specificity 91%). The diagnostic performance of various variables of the leukogram was poor to moderate (ROC AUC 0.625–0.828). 68% of dogs with HA had a Na/KR ≤ 22 and a N/LR ≤ 2.3, a combination not observed in dogs with non-adrenal diseases. Conclusion and clinical relevance: As secondary HA is very rare, endogenous ACTH measurement is a very good alternative to the traditional ACTH response test. Data also suggest that the combination of a Na/KR ≤ 22 and a N/LR ≤ 2.3 is highly specific and can be used to rule in HA.
Exceptional points in the spectra of atoms in external fields

We investigate exceptional points, which are branch-point singularities of two resonance eigenstates, in spectra of the hydrogen atom in crossed external electric and magnetic fields. A procedure to systematically search for exceptional points is presented, and their existence is proven. The properties of the branch-point singularities are discussed with effective low-dimensional matrix models, their relation with avoided level crossings is analyzed, and their influence on dipole matrix elements and the photoionization cross section is investigated. Furthermore, the rare case of a connection between three resonances almost forming a triple degeneracy in the form of a cubic-root branch point is discussed.
TESTING AND COMMISSIONING PROCESS FOR A LIGHT RAIL PROJECT

This paper discusses a testing and commissioning model for a typical light rail project. The paper does not propose a new methodology or concept, but the idea is to consolidate different testing and commissioning exercises into a generic structure of stages, which can be applicable to any light rail project. The various stages depend on the level of testing and integration required as a project progresses from supply of equipment and installation to integration and actual operation. Systems integration is a vital aspect of the testing and commissioning programme, and is discussed in brief in this context. The documention and control necessary to complete the testing and commissioning programme are also outlined.
Deterministic computations whose history is independent of the order of asynchronous updating

Consider a network of processors (sites) in which each site x has a finite set N(x) of neighbors. There is a transition function f that for each site x computes the next state \xi(x) from the states in N(x). But these transitions (updates) are applied in arbitrary order, one or many at a time. If the state of site x at time t is \eta(x,t) then let us define the sequence \zeta(x,0), \zeta(x,1), . by taking the sequence \eta(x,0), \eta(x,1), . , and deleting repetitions. The function f is said to have invariant histories if the sequence \zeta(x,i), (while it lasts, in case it is finite) depends only on the initial configuration, not on the order of updates. This paper shows that though the invariant history property is typically undecidable, there is a useful simple sufficient condition, called commutativity: For any configuration, for any pair x,y of neighbors, if the updating would change both \xi(x) and \xi(y) then the result of updating first x and then y is the same as the result of doing this in the reverse order.
The S-Layer Glycoprotein of the Crenarchaeote Sulfolobus acidocaldarius Is Glycosylated at Multiple Sites with Chitobiose-Linked N-Glycans

Glycosylation of the S-layer of the crenarchaea Sulfolobus acidocaldarius has been investigated using glycoproteomic methodologies. The mature protein is predicted to contain 31 N-glycosylation consensus sites with approximately one third being found in the C-terminal domain spanning residues L1004-Q1395. Since this domain is rich in Lys and Arg and therefore relatively tractable to glycoproteomic analysis, this study has focused on mapping its N-glycosylation. Our analysis identified nine of the 11 consensus sequence sites, and all were found to be glycosylated. This constitutes a remarkably high glycosylation density in the C-terminal domain averaging one site for each stretch of 30–40 residues. Each of the glycosylation sites observed was shown to be modified with a heterogeneous family of glycans, with the largest having a composition Glc1Man2GlcNAc2 plus 6-sulfoquinovose (QuiS), consistent with the tribranched hexasaccharide previously reported in the cytochrome b558/566 of S. acidocaldarius. S. acidocaldarius is the only archaeal species whose N-glycans are known to be linked via the chitobiose core disaccharide that characterises the N-linked glycans of Eukarya.
Chronic inflammatory demyelinating polyneuropathy after Campylobacter jejuni infection mimicking vasculitic mononeuritis multiplex in a diabetic

Abstract Chronic inflammatory demyelinating polyneuropathy (CIDP) is a clinically heterogeneous disorder. Recent reports suggest that CIDP could be more frequent in diabetics. We report here a case of CIDP presenting as mononeuritis multiplex with accompanying cranial nerve involvement in an insulin‐dependent diabetic who presented a preceding Campylobacter jejuni infection and misleading skin lesions. Treatment with intravenous immunoglobulins was successful. This case suggests that CIDP should be considered as a potential diagnosis in all diabetics with localized, acute or sub‐acute onset, and multiple, or overlapping mononeuropathies.
Combining network coding and compressed sensing for error correction in wireless sensor networks

As the spatial and temporal correlations of sensor readings are common in wireless sensor networks, motivated by these features and the drawbacks of network coding (NC), we introduce compressed sensing (CS) into NC scheme and construct a cooperating coding mechanism, which performs over different data fields with a compatible transformation measure for the combination of NC and CS. This cooperating coding scheme can reduce the amount of redundant information transmission significantly, because the temporal and spatial correlations are explored fully. Meanwhile, the erasures and errors are considered simultaneously in relay transmission process; a NC decoding for error control is proposed to correct the erasures and errors. Although the decoding error of NC is existent, this error can be further reduced by the reconstruction process of CS; as a result, the relative recovery error is small enough in the sink. Finally, the reliability and performance analyses confirm that the proposed cooperating coding scheme obtains considerable compression gain as compared with conventional coding scheme of NC and transmits information reliably with high recovery precision. Copyright © 2014 John Wiley & Sons, Ltd.
Search for Program Structure

The community of programming language research loves the Curry-Howard correspondence between proofs and programs. Cut-elimination as computation, theorems for free, call/cc as excluded middle, dependently typed languages as proof assistants, etc. Yet we have, for all these years, missed an obvious observation: “the structure of programs corresponds to the structure of proof search”. For pure programs and intuitionistic logic, more is known about the latter than the former. We think we know what programs are, but logicians
Mechanical Properties of Skin and Liposuction

BACKGROUND Liposuction removes fat, setting the skin under tension, and could therefore alter the overall viscodastic properties of the teguments. OBJECTIVE To measure in vivo the mechanical properties of skin at the site of liposuction and to compare the viscoelastic values with those of the inner aspect of the forearms. METHODS The Cutometer SEM 474 equipped with a 8‐mm probe was used. RESULTS Data show that cutaneous laxity, which is characteristic for an aging aspect, is not higher at the liposuction sites than on the reference area. CONCLUSION Liposuction does not increase the clinical aspects of skin aging.
Efficient Hardware Design of Iterative Stencil Loops

A large number of algorithms for multidimensional signals processing and scientific computation come in the form of iterative stencil loops (ISLs), whose data dependencies span across multiple iterations. Because of their complex inner structure, automatic hardware acceleration of such algorithms is traditionally considered as a difficult task. In this paper, we introduce an automatic design flow that identifies, in a wide family of bidimensional data processing algorithms, subportions that exhibit a kind of parallelism close to that of ISLs; these are mapped onto a space of highly optimized ad-hoc architectures, which is efficiently explored to identify the best implementations with respect to both area and throughput. Experimental results show that the proposed methodology generates circuits whose performance is comparable to that of manually optimized solutions, and orders of magnitude higher than those generated by commercial high-level synthesis tools.
MiR-338-5p suppresses rheumatoid arthritis synovial fibroblast proliferation and invasion by targeting ADAMTS-9.

OBJECTIVES We proposed to find out the role of miR-338-5p played in cell proliferation and invasion of rheumatoid arthritis synovial fibroblasts (RASFs) by regulating ADAMTS-9. METHODS QRT-PCR was performed to quantify the miR-338-5p and ADAMTS-9 mRNA expression in RA sample tissues and normal synovial tissues. Western blot was performed to evaluate the ADAMTS-9 protein levels in transfected RASFs. Luciferase reporter assays were used to demonstrate whether miR338-5p directly targets ADAMTS-9. MTT, Transwell and wound healing assays were respectively used to evaluate the growth and mobility of RASFs. Flow cytometry was applied to detect cell cycle distributions and apoptosis rates in transfected RASFs. RESULTS MiR-338-5p was significantly downregulated in rheumatoid arthritis (RA) tissues while ADAMTS-9 was obviously overexpressed (p<0.001). Luciferase reporter assays demonstrated that miR-338-5p directly targeted ADAMTS-9. Moreover, overexpression of miR-338-5p suppressed RASFs biological functions and induced G0/G1 arrest and apoptosis of RASFs (p<0.001), while all the effects could be efficiently attenuated by the upregulation of ADAMTS-9. CONCLUSIONS By inhibiting ADAMTS-9, miR-338-5p suppressed the proliferation and metastasis of rheumatoid arthritis synovial fibroblasts. Thus, replenishing miR-338-5p may be a potential therapy for the clinic management of RA.
Changes in intergenerational mobility in britain

© Cambridge University Press 2004 and 2009. The extent to which children's economic or social success is shaped by the economic or social position of their parents is a contentious and hotly debated issue, both within academic circles and in a wider policy context. There is a large body of academic work, carried out predominantly by sociologists, on social mobility – where social class of individuals is related to parental social class – and a smaller body of work which considers mobility in terms of economic status (usually measured by labor market earnings of children and parents). An example of the former is the survey undertaken in the Performance and Innovation Unit (2001) paper on social mobility, while Solon (1999) offers an overview of the latter. Further, the issue of intergenerational inequalities crops up in the political arena time and time again, and one increasingly sees discussion of the issue in the political press. The experiences of the last twenty years or so probably make such issues even more relevant than ever. In the United Kingdom income inequality increased very rapidly since the late 1970s (Goodman, Johnson, and Webb 1997). Much of this has been due to changing rewards from paid work as earnings gaps between the highest- and lowest-paid workers widened out by a considerable amount (Machin 1996, 1998, 1999). One consequence of this has been a massive rise in the proportion of children growing up in poverty.
Effect‐directed analysis of mutagens and ethoxyresorufin‐O‐deethylase inducers in aquatic sediments

Sediment extracts from a creek in the Neckar river basin (Germany), which received the discharge of treated hospital wastewater, were found to exhibit strong aromatic hydrocarbon (Ah) receptor‐mediated effects in a rainbow trout liver cell line (RTL‐W1) as well as high mutagenicity in the Salmonella/microsome assay after fractionation. The crude extract did not exhibit a clear mutagenic response. Apparently, cleanup or fractionation before mutagenicity testing is necessary to minimize the risk of false‐negative results. Effect‐directed fractionation and analysis were applied to characterize and identify the toxicants that cause these effects. Major ethoxyresorufin‐O‐deethylase induction potency and mutagenicity were detected in different polyaromatic fractions, indicating different sets of toxicants that induce metabolic activation and mutagenicity. Dioxin‐like halogenated aromatic hydrocarbons, including polychlorinated biphenyls, naphthalenes, dibenzo‐p‐dioxins and furans, and priority polycyclic aromatic hydrocarbons, contributed to Ah receptor‐mediated activity only to a minor extent. Benzo[a]pyrene, benzo[a]fluoranthene, and perylene could be confirmed as important contributors to mutagenicity. The nonpriority pollutants 11H‐indeno[2,1,7‐cde]pyrene, a methylbenzo[e]pyrene, and a methylperylene were tentatively identified as major components, representing 82% of the peak area of a highly mutagenic fraction of the sediment extract. This suggests that hazard and risk assessment of complex environmental mixtures should make increasing attempts to identify and consider hazardous key pollutants rather than focusing on a priori‐selected key pollutants alone.
Testing semi-Lagrangian schemes for two-phase flow applications

The ability of semi-Lagrangian schemes to transport non-diffusive scalars in two-phase flow simulations employing an Eulerian formulation was tested. Conservation and positivity of the schemes was ensured by using specially designed interpolants available in the literature. A simple improvement of the algorithm to minimize numerical diffusion was proposed. The application of the scheme to DNS of a rod of fluid particles advected in homogeneous turbulence showed good agreement of the computed number density with a baseline solution obtained with Lagrangian particle tracking.
Interdependence of environmental factors influencing reciprocal patterns of gene expression in virulent Borrelia burgdorferi

The paradigm for differential antigen expression in Borrelia burgdorferi, the agent of Lyme disease, is the reciprocal expression of its outer surface (lipo)proteins (Osp) A and C; as B. burgdorferi transitions from its arthropod vector into mammalian tissue, ospC is upregulated, and ospA is downregulated. In the current study, using B. burgdorferi cultivated under varying conditions in BSK‐H medium, we found that a decrease in pH, in conjunction with increases in temperature (e.g. 34°C or 37°C) and cell density, acted interdependently for the reciprocal expression of ospC and ospA. The lower pH (6.8), which induced the reciprocal expression of ospC and ospA in BSK‐H medium, correlated with a drop in pH from 7.4 to 6.8 of tick midgut contents during tick feeding. In addition to ospC and ospA, other genes were found to be regulated in reciprocal fashion. Such genes were either ospC‐like (e.g. ospF, mlp‐8 and rpoS) (group I) or ospA‐like (lp6.6 and p22) (group II); changes in expression occurred at the mRNA level. That the expression of rpoS, encoding a putative stress‐related alternative sigma factor (σs), was ospC‐like suggested that the expression of some of the group I genes may be controlled through σs. The combined results prompt a model that allows for predicting the regulation of other B. burgdorferi genes that may be involved in spirochaete transmission, virulence or mammalian host immune responses.
All-pass digital filter design in the frequency-delay domain using the iterative quadratic maximum likelihood algorithm

A new domain, termed the frequency-delay is used to design stable, all-pass digital filters resembling a given delay response in the least-squares sense. This spectral technique identifies the delay response of a stable, second-order, all-pass digital filter as a double sideband suppressed carrier amplitude modulated signal in the frequency-delay domain. Iterative maximum likelihood techniques are used to render the filter coefficients. The algorithm is a significant improvement over related methods because it results in a physically realizable stable all-pass filter that closely approximates a desired delay response.
The Nomad and the Couch Potato: Enriching Mobile Shared Experiences with Contextual Information

Mobile videoconferencing is increasingly being used to bring remote friends or family along to an activity happening outside the home, such as shopping or visiting a tourist attraction. We explored how including contextual information of the event, in addition to audio and video of the person at the event, impacts the shared experience. We studied three kinds of information: a map showing the position of the person at the activity, a second live video showing what was in front of that person, and periodic high quality images showing what was in front of the person. We carried out a field study with twelve pairs of participants, where one participant (the nomad) was at a self-selected activity while the other (the couch potato) joined the activity from our living room lab. The study results show that including contextual information significantly improved connectedness and the sense of presence for both participants. Each type of contextual information offered unique benefits. The map was used for orientation and to provide directions, the live video for "do you see this" moments and to maintain a sense of liveliness, and the periodic images for "did you see that" moments and to see greater detail. Together they led to smooth view negotiation, activity input from the couch potato, and high levels of engagement.