Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessment of Pain When Uncovering Implants with Er:YAG Laser or Scalpel for Second Stage Surgery.

BACKGROUND Different methods aimed at decreasing pain during some soft tissue procedures in dentistry are still under research. Modern devices as lasers could be a method to reduce the pain and duration of second stage implant surgery. OBJECTIVES To assess the pain and the impression quality when uncovering implants with a laser and with a scalpel. MATERIAL AND METHODS The analysis included 60 implants (Dentium SuperLine, Suwon, Korea) in 30 patients (23 women and 7 men) aged 25-69. In the experimental group, 30 implants were uncovered by means of an Er:YAG laser (LiteTouch®, Syneron Dental, Yokneam, Israel) with the following fixed operation parameters: 300 mJ, 18 Hz, water cooling at 40%, energy density per pulse: 38.21 J/cm2, tip size: 1.0 × 17 mm, distance: 2 mm, tip angle set at 70°, no anesthesia. As a control, 30 implants were uncovered using a scalpel and topical application of 20% benzocaine. An 11-point numeric pain rating scale (NRS-11) was used to evaluate the pain level. A 3-point prosthetic impression scale (PIS) designed by the authors was used to assess the quality of the impression of the implant emergence profile. RESULTS The mean value of pain assessed on the NRS-11 for the Er:YAG laser and scalpel were 2.6 and 6, respectively. The mean value of pain for the laser and scalpel at a supracrestal height of periimplant soft tissue (SHPST) ≤ 3 mm were 1.8 and 4.7 respectively, and for SHPST > 3 mm the values were 3.3 and 7.4, respectively. The implant emergence profile impression showed satisfactory or ideal quality in 26 cases. CONCLUSIONS The use of Er:YAG laser reduces pain and allows minor surgical procedures to be carried out without anesthesia. The impression quality is satisfactory for the preparation of prosthetic reconstructions.
AUTONOMOUS ROBOT LEARNING MODEL BASED ON VISUAL INTERPRETATION OF SPATIAL STRUCTURES

The main concept of the presented research is an autonomous robot learning model for which a novel ARTgrid neural network architecture for classification of spatial structures is utilized. The motivation scenario includes incremental unsupervised learning which is mainly based on discrete spatial structure changes recognized by the robot vision system. The learning policy problem is represented as a classification problem for which the adaptive resonance theory (ART) concept is implemented. Main methodology and architecture of the autonomous robot learning model with preliminary results is presented. A computer simulation was performed with four input sets set containing 22, 45, 73 and 111 random spatial structures. ARTgrid shows a fairly high (>85%) match score when applied with already learned patterns after the first learning cycle, and a score >95% after the second cycle. Regarding category proliferation the results are compared with a more predictive modified cluster centre seeking algorithm.
Single Channel Analysis of Isoflurane and Ethanol Enhancement of Taurine-Activated Glycine Receptors

The amino acid taurine is an endogenous ligand acting on glycine receptors (GlyRs), which is released by astrocytes in many brain regions, such as the nucleus accumbens and prefrontal cortex. Taurine is a partial agonist with an efficacy significantly lower than that of glycine. Allosteric modulators such as ethanol and isoflurane produce leftward shifts of glycine concentration-response curves but have no effects at saturating glycine concentrations. In contrast, in whole-cell electrophysiology studies these modulators increase the effects of saturating taurine concentrations. A number of possible mechanisms may explain these enhancing effects, including modulator effects on conductance, channel open times, or channel closed times. We used outside-out patch-clamp single channel electrophysiology to investigate the mechanism of action of 200 mM ethanol and 0.55 mM isoflurane in enhancing the effects of a saturating concentration of taurine. Neither modulator enhanced taurine-mediated conductance. Isoflurane increased the probability of channel opening. Isoflurane also increased the lifetimes of the two shortest open dwell times while both agents decreased the likelihood of occurrence of the longest-lived intracluster channel-closing events. The mechanism of enhancement of GlyR functioning by these modulators is dependent on the efficacy of the agonist activating the receptor and the concentration of agonist tested.
Monetary Policy as Financial-Stability Regulation

This paper develops a model that speaks to the goals and methods of financialstability policies. There are three main points. First, from a normative perspective, the model defines the fundamental market failure to be addressed, namely that unregulated private money creation can lead to an externality in which intermediaries issue too much short-term debt and leave the system excessively vulnerable to costly financial crises. Second, it shows how in a simple economy where commercial banks are the only lenders, conventional monetary-policy tools such as open-market operations can be used to regulate this externality, while in more advanced economies it may be helpful to supplement monetary policy with other measures. Third, from a positive perspective, the model provides an account of how monetary policy can influence bank lending and real activity, even in a world where prices adjust frictionlessly and there are other transactions media besides bank-created money that are outside the control of the central bank.
The Crestal Approach: Antral Membrane Elevation Via a Post Graft

The crestal approach to elevating the antral membrane by a resorbable StemVie Post is a modification of the sinus lift technique. This technique can add 4 to 10 mm bone height for severely atrophic ridges in areas that are difficult to access through a lateral window. The procedure is minimally invasive, simple, predictable, and has less postoperative morbidity because of smaller flap design and minimal osteotomy. If sufficient alveolar bone is present for stabilization, an implant can be placed simultaneous with antral elevation and graft. The StemVie Post completely resorbs and is replaced by the patient's own bone.
Human TRPV4 Channel Splice Variants Revealed a Key Role of Ankyrin Domains in Multimerization and Trafficking*

The TRPV4 cation channel exhibits a topology consisting of six predicted transmembrane domains (TM) with a putative pore loop between TM5 and TM6 and intracellular N- and C-tails, the former containing at least three ankyrin domains. Functional transient receptor potential (TRP) channels are supposed to result following the assembly of four subunits. However, the rules governing subunit assembly and protein domains implied in this process are only starting to emerge. The ankyrin, TM, and the C-tail domains have been identified as important determinants of the oligomerization process. We now describe the maturation and oligomerization of five splice variants of the TRPV4 channel. The already known TRPV4-A and TRPV4-B (Δ384–444) variants and the new TRPV4-C (Δ237–284), TRPV4-D (Δ27–61), and TRPV4-E (Δ237–284 and Δ384–444) variants. All alternative spliced variants involved deletions in the cytoplasmic N-terminal region, affecting (except for TRPV4-D) the ankyrin domains. Subcellular localization, fluorescence resonance energy transfer, co-immunoprecipitation, glycosylation profile, and functional analysis of these variants permitted us to group them into two classes: group I (TRPV4-A and TRPV4-D) and group II (TRPV4-B, TRPV4-C, and TRPV4-E). Group I, unlike group II variants, were correctly processed, homo- and heteromultimerized in the endoplasmic reticulum, and were targeted to the plasma membrane where they responded to typical TRPV4 stimuli. Our results suggest that: 1) TRPV4 biogenesis involves core glycosylation and oligomerization in the endoplasmic reticulum followed by transfer to the Golgi apparatus for subsequent maturation; 2) ankyrin domains are necessary for oligomerization of TRPV4; and 3) lack of TRPV4 oligomerization determines its accumulation in the endoplasmic reticulum.
Erroneous selection of a non-target item improves subsequent target identification in rapid serial visual presentations

The second of two targets (T2) embedded in a rapid serial visual presentation (RSVSVP) is often missed even though the first (T1) is correctly reported (attentional blink). The rate of correct T2 identification is quite high, however, when T2 comes immediately after T1 (lag-1 sparing). This study investigated whether and how non-target items induce lag-1 sparing. One T1 and two T2s comprising letters were inserted in distractors comprising symbols in each of two synchronised RSVSVPs. A digit (dummy) was presented with T1 in another stream. Lag-1 sparing occurred even at the location where the dummy was present (Experiment 1). This distractor-induced sparing effect was also obtained even when a Japanese katakana character (Experiment 2) was used as the dummy. The sparing effect was, however, severely weakened when symbols (Experiment 3) and Hebrew letters (Experiment 4) served as the dummy. Our findings suggest a tentative hypothesis that attentional set for item nameability is meta-categorically created and adopted to the dummy only when the dummy is nameable.
3D Encoding/2D Decoding of Medical Data

We propose a fully three-dimensional wavelet-based coding system featuring 3D encoding/2D decoding functionalities. A fully threedimensional transform is combined with context adaptive arithmetic coding; 2D decoding is enabled by encoding every 2D subband image independently. The system allows a finely graded up to lossless quality scalability on any 2D image of the dataset. Fast access to 2D images is obtained by decoding only the corresponding information thus avoiding the reconstruction of the entire volume. The performance has been evaluated on a set of volumetric data and compared to that provided by other 3D as well as 2D coding systems. Results show a substantial improvement in coding efficiency (up to 33%) on volumes featuring good correlation properties along the z axis. Even though we did not address the complexity issue, we expect a decoding time of the order of one second/image after optimization. In summary, the proposed 3D/2D Multidimensional Layered Zero Coding System (3D/2D MLZC) provides the improvement in compression efficiency attainable with 3D systems without sacrificing the effectiveness in accessing the single images characteristic of 2D ones.
Reliability-driven layout decompaction for electromigration failure avoidance in complex mixed-signal IC designs

The negative effect of electromigration on signal and power line lifetime and functional reliability is an increasingly important problem for the physical design of integrated circuits. We present a new approach that addresses this electromigration issue by considering current density and inhomogeneous current-flow within arbitrarily shaped metallization patterns during physical design. Our proposed methodology is based on a post-route modification of critical layout structures that utilizes current-density data from a previously performed current-density verification. It is especially tailored to overcome the lack of current-flow consideration within existing routing tools. We also present experimental results obtained after successfully integrating our methodology into a commercial IC design flow.
Human Cancer Protein-Protein Interaction Network: A Structural Perspective

Protein-protein interaction networks provide a global picture of cellular function and biological processes. Some proteins act as hub proteins, highly connected to others, whereas some others have few interactions. The dysfunction of some interactions causes many diseases, including cancer. Proteins interact through their interfaces. Therefore, studying the interface properties of cancer-related proteins will help explain their role in the interaction networks. Similar or overlapping binding sites should be used repeatedly in single interface hub proteins, making them promiscuous. Alternatively, multi-interface hub proteins make use of several distinct binding sites to bind to different partners. We propose a methodology to integrate protein interfaces into cancer interaction networks (ciSPIN, cancer structural protein interface network). The interactions in the human protein interaction network are replaced by interfaces, coming from either known or predicted complexes. We provide a detailed analysis of cancer related human protein-protein interfaces and the topological properties of the cancer network. The results reveal that cancer-related proteins have smaller, more planar, more charged and less hydrophobic binding sites than non-cancer proteins, which may indicate low affinity and high specificity of the cancer-related interactions. We also classified the genes in ciSPIN according to phenotypes. Within phenotypes, for breast cancer, colorectal cancer and leukemia, interface properties were found to be discriminating from non-cancer interfaces with an accuracy of 71%, 67%, 61%, respectively. In addition, cancer-related proteins tend to interact with their partners through distinct interfaces, corresponding mostly to multi-interface hubs, which comprise 56% of cancer-related proteins, and constituting the nodes with higher essentiality in the network (76%). We illustrate the interface related affinity properties of two cancer-related hub proteins: Erbb3, a multi interface, and Raf1, a single interface hub. The results reveal that affinity of interactions of the multi-interface hub tends to be higher than that of the single-interface hub. These findings might be important in obtaining new targets in cancer as well as finding the details of specific binding regions of putative cancer drug candidates.
Design, modelling and simulation of soft grippers using new bimorph pneumatic bending actuators

Abstract Soft compliant grasping is essential in delicate manipulation tasks typically required in manufacturing and/or medical applications to prevent stress concentration at the point of contact. In comparison with their rigid counterparts, the intrinsic compliance of soft grippers offers simpler control and planning of the grasping action, especially where robots are faced with a number of objects varying in shape and size. However, quantitative analysis is rarely utilized in the design and fabrication of soft grippers, due to the fact that significant and complex deformation occurs once the soft gripper is in contact with external objects. In this paper, we demonstrate the design of a soft gripper using our novel bimorph-like pneumatic bending actuators. The gripper was modelled through finite element analysis to reflect its gripping capability during interaction with certain targeted objects. The proposed systematic design and analytical model was validated via experiments. The system’s gripping capability was evaluated with objects of different weight and dimension. In addition, compliance testing has proved that the proposed soft gripper is able to grip objects of 60 g from the side, without causing exceeding concentration stress on the targeted object.
Towards Measuring Scalability in Natural Language Understanding Tasks

In this paper we present a discussion of existing metrics for evaluation the performance of individual natural language understanding systems and components as well as the commonly employed metrics for measuring the speciﬁc task difﬁculties. We extend and generalize the common majority class baseline metric and introduce an general entropy-based metric for measuring the task difﬁculty of arbitrary language understanding tasks. Finally, we show an empirical study evaluating this metric followed by a discussion of its role in measuring the scalability of language understanding systems and components.
Undiagnosed sleep‐related breathing disorders are associated with focal brainstem atrophy in the elderly

Background: Sleep‐related breathing disorders (SRBDs) affect as many as 40% of elderly people. The association of SRBDs with structural brain abnormalities remains unclear. In this observational study, we evaluated gray matter changes in the brain associated with sleep abnormalities in volunteers and their relationship with the severity of SRBDs. Methods: One hundred fifty two healthy subjects aged 66.0 ± 0.6 years‐old underwent tridimensional brain MRI and nocturnal polygraphic recording during which apnea/hypopnea index (AHI) and the oxyhemoglobin desaturation index (ODI) were measured. Using voxel‐based morphometry, we investigated the presence of gray matter abnormalities in association with AHI and ODI. Findings: Seventy‐six subjects (50%) had SRBDs defined by an AHI ≥ to 15 and 25 subjects (16%) SRBDs defined by an ODI ≥ 15, in the absence of systematic excessive daytime sleepiness. A significant symmetrical loss of gray matter in the intermediate reticular zone of the bulbopontine area was found to correlate with both AHI and ODI (P < 0.05 corrected for multiple comparisons for cluster significance). Interpretation: This gray matter volume decrease in brain regions involved in breathing/autonomic functions, as well as their correlation with the severity of the disorder, suggests a pathophysiological link between structural changes and SRBDs. Hum Brain Mapp, 2009. © 2008 Wiley‐Liss, Inc.
A brain-machine interface to navigate mobile robots along human-like paths amidst obstacles

This paper presents an interface that allows a human user to specify a desired path for a mobile robot in a planar workspace with noisy binary inputs that are obtained at low bit-rates through an electroencephalograph (EEG). We represent desired paths as geodesics with respect to a cost function that is defined so that each path-homotopy class contains exactly one (local) geodesic. We apply max-margin structured learning to recover a cost function that is consistent with observations of human walking paths. We derive an optimal feedback communication protocol to select a local geodesic-equivalently, a path-homotopy class-using a sequence of noisy bits. We validate our approach with experiments that quantify both how well our learned cost function characterizes human walking data and how well human subjects perform with the resulting interface in navigating a simulated robot with EEG.
The Everyday Moral Judge – Autobiographical Recollections of Moral Emotions

Moral emotions are typically elicited in everyday social interactions and regulate social behavior. Previous research in the field of attribution theory identified ought (the moral standard of a given situation or intended goal), goal-attainment (a goal can be attained vs. not attained) and effort (high vs. low effort expenditure) as cognitive antecedents of moral emotions. In contrast to earlier studies, mainly relying on thought experiments, we investigated autobiographical recollections of N = 312 participants by means of an online study. We analyzed a diverse range of moral emotions, i.e., admiration, anger, contempt, indignation, pride, respect, schadenfreude, and sympathy, by using a mixed-method approach. Qualitative and quantitative methods clearly corroborate the important role of ought, goal-attainment, and effort as eliciting conditions of moral emotions. Furthermore, we built categorical systems based on our participants’ descriptions of real-life situations, allowing for more fine-grained distinctions between seemingly similar moral emotions. We thus identify additional prerequisites explaining more subtle differences between moral emotion clusters as they emerge from our analyses (i.e., cluster 1: admiration, pride, and respect; cluster 2: anger, contempt, and indignation; cluster 3: schadenfreude and sympathy). Results are discussed in the light of attributional theories of moral emotions, and implications for future research are derived.
The relative contribution of vectors to the introduction and translocation of invasive marine species

Keeping marine pests out of Australian waters Important The Australian Government Department of Agriculture, Fisheries and Forestry advises that the information contained in this report is based on scientific research and is intended to inform the development of public policy. Readers are advised and need to be aware that this information may be incomplete or unsuitable for use in any specific situation. Before taking any action or decision based on the information in this publication, readers should seek professional, scientific and technical advice. To the extent permitted by law, the Australian Government and the Department of Agriculture, Fisheries and Forestry (including its employees, consultants and advisers) disclaim all liability, including liability for negligence, for any direct or consequential loss, damage, death, injury, expense, liability or cost incurred or suffered by any person (including corporate entities or bodies politic) as a result of accessing, using or relying on any of the information or data contained in this publication. This work is copyright. You may download, store in cache, display, print, reproduce, distribute or communicate these materials in an unaltered form only (retaining this notice) provided no monetary consideration is received in exchange and that the work is not dealt with in a manner that is misleading or deceptive. Apart from any use as permitted under the 4 the relative contribution of vectors to the introduction and translocation of invasive marine species Executive summary Whether intentional or not, humans have been responsible for the translocation of invasive marine species. The indicative representations of association suggest that biofouling has been the most prevalent mechanism contributing to such invasions across the globe. Biofouling is one of the oldest mechanisms of human-mediated transport of marine species, beginning with early human movements on small scales and eventually leading to world explorations with the European Expansion from 1500 AD onwards. The most common means of biofouling is marine species attaching themselves to any part of a vessel, or any equipment attached to or onboard the vessel, aquaculture equipment and mooring devices. In contrast, ballast water is a relatively new vector of transport, with the earliest ballast water use recorded in the late 19th century. Ballast water – water (including sediment that has been contained in water) held in tanks and cargo holds of ships to increase stability and manoeuvrability during transit – represents an expansion of transport opportunity to the vast majority of the benthic species associated …
Two-stage acquisition for UWB in dense multipath

In UWB acquisition in dense multipath environments, there exist multiple delays (or cells) within the timing uncertainty region that can lead to an acquisition lock, due to UWB's fine time resolution. Most acquisition schemes are designed to lock onto an arbitrary multipath, or onto the strongest multipath. This is especially undesirable for ranging applications, since it is critical to capture the LOS path. In this paper, we propose a two-stage acquisition algorithm for UWB ranging applications. The first stage, called coarse acquisition, is a fast version of traditional serial search, which locks onto an arbitrary multipath component. The second acquisition stage performs a finer search over a reduced uncertainty region. The fine acquisition stage uses an estimate of the noise variance, obtained from the first stage. It also takes advantage of the clustered nature of the multipath to detect the LOS path, even when it is severely attenuated. The gains brought by the proposed model are verified by simulation