Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficient And Secure Autonomous System Based Traceback

The design of the IP protocol makes it difficult to reliably identify the originator of an IP packet, causing the defense against Distributed Denial of Service attacks to become one of the hardest problems on the Internet today. Previous solutions for this problem try to traceback to the exact origin of the attack by requiring every router’s participation. For many reasons this requirement is impractical and the victim results with an approximate location of the attacker. Reconstruction of the whole path is also very difficult due to the sheer size of the Internet. This paper presents lightweight schemes for tracing back to the attack-originating AS instead to the exact origin itself. Once the attack-originating AS is determined, all further routers in the path to the attacker are within that AS and under the control of a single entity; which can presumably monitor local traffic in a more direct way than a generalized, Internet scale, packet marking scheme can. We furthermore, provide a scheme to prevent compromised routers from forging markings.
Optical recording of electrical activity from parallel fibres and other cell types in skate cerebellar slices in vitro.

1. A reliable and simple fish brain slice preparation was obtained from the cerebellum of the skate, and its properties were described. 2. A potentiometric oxonol dye, RH‐482, and multiple site optical recording of transmembrane voltage (MSORTV) were used to reveal the electrophysiological properties of the parallel fibre action potential and to measure its conduction (0.13 m/s). The parallel fibre action potential was blocked in the presence of tetrodotoxin (TTX) and prolonged by tetraethylammonium (TEA), suggesting that the upstroke depends upon sodium entry and the repolarization upon potassium efflux. An after‐hyperpolarization results from a calcium‐dependent potassium conductance. 3. A second potentiometric dye, RH‐155, differing only slightly from RH‐482, exhibited a high affinity for glial cell membrane, and could be used to monitor changes in extracellular potassium concentration by detecting changes in glial membrane potential. 4. Calcium channel blockers such as cadmium ions blocked the optical signal that reflected the extracellular accumulation of potassium. 5. Interventions that modified the extracellular volume, and thereby affected the accumulation of potassium, produced large changes in the optical signal that monitored glial depolarization. Hypertonic and hypotonic bathing solutions resulted in decreases and increases, respectively, in the magnitude of the extrinsic absorption change that tracked potassium accumulation. 6. Blocking sodium‐potassium pump activity by means of ouabain prolonged the time course of the optical signal that was related to potassium accumulation in the extracellular space. 7. Extracellular potassium accumulation was revealed to be critically dependent upon intracellular calcium ions.
FoxM1 Is a General Target for Proteasome Inhibitors

Proteasome inhibitors are currently in the clinic or in clinical trials, but the mechanism of their anticancer activity is not completely understood. The oncogenic transcription factor FoxM1 is one of the most overexpressed genes in human tumors, while its expression is usually halted in normal non-proliferating cells. Previously, we established that thiazole antibiotics Siomycin A and thiostrepton inhibit FoxM1 and induce apoptosis in human cancer cells. Here, we report that Siomycin A and thiostrepton stabilize the expression of a variety of proteins, such as p21, Mcl-1, p53 and hdm-2 and also act as proteasome inhibitors in vitro. More importantly, we also found that well-known proteasome inhibitors such as MG115, MG132 and bortezomib inhibit FoxM1 transcriptional activity and FoxM1 expression. In addition, overexpression of FoxM1 specifically protects against bortezomib-, but not doxorubicin-induced apoptosis. These data suggest that negative regulation of FoxM1 by proteasome inhibitors is a general feature of these drugs and it may contribute to their anticancer properties.
Resistance in Soybean Cultivars from Maturity Groups V-VIII to Soybean Cyst and Root-knot Nematodes.

One hundred thirty-nine cultivars of soybean (Glycine max) in Maturity Groups V, VI, VII, and VIII were evaluated in a greenhouse for resistance to Heterodera glycines races 3 and 14 and Meloidogyne incognita, M. arenaria, and M. javanica. Of the cultivars tested, 37% had resistance to H. glycines race 3 alone, 12% had resistance to both races 3 and 14, and 69% exhibited a moderate or high level of resistance to one or more of the Meloidogyne spp. However, 24% were susceptible to each race of H. glycines and to all Meloidogyne spp. Whereas 40% of the cultivars were moderately resistant to M. javanica, only 23% were moderately resistant to M. incognita and 24% to M. arenaria. Although 28% of the cultivars had a high level of resistance to M. incognita, only 6 and 3% had this level of resistance to M. javanica and M. arenaria, respectively. Seventeen percent of the cultivars possessed a moderate or high level of resistance to all three Meloidogyne spp. , and 37 % had resistance to H. glycines race 3 and M. incognita. With the exception of resistance to H. glycines race 14, resistance in soybean to these nematodes was fairly uniformly distributed across maturity groups.
Experimental myocardial infarction: IV. Reduction of left ventricular compliance in the healing phase

Compliance of the infarcted left ventricle was studied in dogs 3-5 days after occlusion of the left anterior descending coronary artery. Compliance was assessed from postmortem pressure-volume curves and from pressure-length measurements (mercury-in-silastic segment length gauges) made both in vivo and postmortem. Postmortem pressure-volume curves showed reduced compliance compared to sham-operated animals. Postmortem pressure-length curves of infarcted and adjacent normal myocardium indicated that the diminished total compliance could be attributed to an increase in stiffness of the infarcted area. This was confirmed by in vivo end-diastolic pressure-length changes produced by transient aortic occlusion. The infarcted area was akinetic, showing neither contraction nor aneurysmal bulging. In addition, anesthetized dogs with infarcts, when compared with sham-operated animals, had similar left ventricular end-diastolic volumes (indicator dilution method), but higher left ventricular end-diastolic pressures. Taken with previous observations, which show that systolic aneurysmal bulging is uniformly present at the onset of ischemia, these results indicate that stiffening of the ischemic myocardium occurs during the first 5 days after infarction, and show that elevation of left ventricular filling pressure does not necessarily signify ventricular dilatation. The results also suggest a mechanism whereby ventricular performance may improve during recovery from acute myocardial infarction.
A potential brain functional biomarker distinguishing patients with Crohn’s disease with different disease stages: a resting-state fMRI study

Background The previous studies have demonstrated that patients with Crohn’s disease in remission (CD-R) have abnormal alterations in brain function. However, whether brain function changes in patients with Crohn’s disease in activity (CD-A) and the relationship with CD-R are still unclear. In this study, we aimed to investigate whether the different levels of disease activity may differentially affect the brain function and to find the brain functional biomarker distinguishing patients with different disease stages by measuring the amplitude of low frequency fluctuations (ALFF). Methods 121 patients with CD and 91 healthy controls (HCs) were recruited. The clinical and psychological assessment of participants were collected. The criteria for the disease activity were the Crohn’s disease activity index (CDAI) scores. CD-R refers to CD patients in remission which the CDAI score is less than 150. Conversely, CD-A refers to CD patients in activity which the CDAI score is ≥150. The ALFF was compared among three groups by performing one-way analysis of variance, followed by a post hoc two-sample t-test. Differences among the groups were selected as seeds for functional connectivity analyses. We also investigated the correlation among clinical, psychological scores and ALFF. Binary logistic regression analysis was used to examine the unique contribution of the ALFF characteristics of the disease stages. Results There were widespread differences of ALFF values among the 3 groups, which included left frontal pole (FP_L), right supramarginal gyrus (SG_R), left angular gyrus (AG_L), right cingulate gyrus (CG_R), right intracalcarine cortex (IC_R), right parahippocampal gyrus (PG_R), right lingual gyrus (LG_R), right precuneous cortex (PC_R), left occipital fusiform gyrus (OFG_L). Significant brain regions showing the functional connections (FC) increased in FP_L, SG_R, PC_R and OFG_L between CD-A and HCs. The erythrocyte sedimentation rate had a negative correlation with the ALFF values in PC_R in the patients with CD. The phobic anxiety values had a negative correlation with the ALFF values in OFG_L. The psychoticism values had a negative correlation with ALFF values in the IC_R. And the hostility values had a positive correlation with the ALFF values in CG_R. Significant brain regions showing the FC increased in FP_L, SG_R, CG_R, PG_R, LG_R and OFG_L between CD-R and HCs. In binary logistic regression models, the LG_R (beta = 5.138, p = 0.031), PC_R (beta = 1.876, p = 0.002) and OFG_L (beta = 3.937, p = 0.044) was disease stages predictors. Conclusion The results indicated the significance of the altered brain activity in the different disease stages of CD. Therefore, these findings present a potential identify neuroimaging-based brain functional biomarker in CD. Additionally, the study provides a better understanding of the pathophysiology of CD.
Towards a test cases generation method for Security Policies

Security Policy specification and testing constitute two fundamental challenges in the development of secure communication systems since they can ensure that a security policy is correctly enforced. Model checking techniques can be used to do such task. Given a system modeling and a test criterion, the model checker can generate a counterexample from which test cases can be deduced. To address the previous challenges, we propose in this paper, a framework to specify a security policy and to test its implementation. This framework is characterized as follows: (1) the security policy enforcement is specified through a new modeling language, S-Promela, (2) the test criteria are expressed by the use of a temporal logic LTL and (3) the test cases are generated by a classical model checking technique.
The effect of preoperative intravenous dexketoprofen trometamol on postoperative pain in minor outpatient urologic surgery.

OBJECTIVE The aim of this prospective double-blind randomized study was to compare the effectiveness of preoperative dexketoprofen trometamol for acute postoperative pain in patients undergoing minor outpatient urologic surgery. MATERIAL AND METHODS Sixty male patients (ASA I and II) undergoing varicocelectomy and testicular sperm extraction (TESE) with standard laryngeal mask airway (LMA) anesthesia were randomly divided into two groups. Patients in Group I (n=30) received 50 mg of dexketoprofen trometamol iv before induction, whereas patients in Group II (n=30) received saline. All patients received standard LMA anesthesia (propofol, sevoflurane and N2O/O2). Analgesic efficacy was evaluated by self-assessment of pain intensity (VAS) at regular intervals. Vital signs, side effects and time to reach a postanesthesia discharge score (PADS) of ≥9 were also recorded. Paracetamol 1 gr iv and tramadol 100 mg iv were used for rescue analgesia. RESULTS Demographic data and duration of surgery were similar in both groups. There was no significant difference between groups with respect to postoperative pain scores and side effects. Although more patients in Group II (60%) required rescue analgesia compared to Group I (33.3%), the difference did not reach statistical significance. CONCLUSION Preoperative IV use of dexketoprofen trometamol iv did not decrease the need for rescue analgesia in patients undergoing minor outpatient urological surgery.
Factors affecting uptake and adherence to breast cancer chemoprevention: a systematic review and meta-analysis

In this systematic review of studies investigating decision-making in the context of breast cancer preventive therapy, we observed low uptake of all agents and poor long-term persistence. Our meta-analysis including over 21 000 women demonstrated that only 1 in 6 eligible women decided to take preventive therapy. Persistence for 5 years was low, limiting the preventive effect in these women.
Hospital, Simulation Center, and Teamwork Training for Eclampsia Management: A Randomized Controlled Trial

OBJECTIVE: To compare the effectiveness of training for eclampsia in local hospitals and a regional simulation center, with and without teamwork theory. METHODS: This study is a randomized controlled trial of training in local hospitals and in a simulation center in the United Kingdom. Midwives and obstetricians working at participating hospitals were randomly assigned to 24 teams. Teams were randomly allocated to training in local hospitals or at a simulation center, and to teamwork theory or not. Performance was evaluated before and after training with a standardized eclampsia scenario captured on video. Outcome measures were completion of tasks, time to completion of tasks, administration of magnesium sulfate, and quality of teamwork. RESULTS: Training was associated with an increase in completion of basic tasks; 87% before training and 100% afterward. Basic tasks were completed more quickly; 55 seconds compared with 27 seconds, P=. 012. The magnesium sulfate loading dose was administered by 61% of teams before training and by 92% afterward (P=.040). There was a shorter median time to administration (116 seconds less; P=.011). Training at the simulation center was not associated with additional improvement. Teamwork generally improved (median global score rose from 2.5 to 4.0; P<.001) but there was no additional benefit from teamwork training. CONCLUSION: Training resulted in enhanced performance with higher rates of completion for basic tasks, shorter times to administration of magnesium sulfate, and improved teamwork. There was no additional benefit from training in a simulation center, and none from teamwork theory. CLINICAL TRIAL REGISTRATION: ISRCTN, http://isrctn.org, ISRCTN67906788, reference number 0270030 LEVEL OF EVIDENCE: I
Superpixel-Based Multitask Learning Framework for Hyperspectral Image Classification

Due to the high spectral dimensionality of hyperspectral images as well as the difficult and time-consuming process of collecting sufficient labeled samples in practice, the small sample size scenario is one crucial problem and a challenging issue for hyperspectral image classification. Fortunately, the structure information of materials, reflecting region of homogeneity in the spatial domain, offers an invaluable complement to the spectral information. Assuming some spatial regularity and locality of surface materials, it is reasonable to segment the image into different homogeneous parts in advance, called superpixel, which can be used to improve the classification performance. In this paper, a superpixel-based multitask learning framework has been proposed for hyperspectral image classification. Specifically, a set of 2-D Gabor filters are first applied to hyperspectral images to extract discriminative features. Meanwhile, a superpixel map is generated from the hyperspectral images. Second, a superpixel-based spatial–spectral Schroedinger eigenmaps (S4E) method is adopted to effectively reduce the dimensions of each extracted Gabor cube. Finally, the classification is carried out by a support vector machine (SVM)-based multitask learning framework. The proposed approach is thus termed Gabor S4E and SVM-based multitask learning (GS4E-MTLSVM). A series of experiments is conducted on three real hyperspectral image data sets to demonstrate the effectiveness of the proposed GS4E-MTLSVM approach. The experimental results show that the performance of the proposed GS4E-MTLSVM is better than those of several state-of-the-art methods, while the computational complexity has been greatly reduced, compared with the pixel-based spatial–spectral Schroedinger eigenmaps method.
Prokaryotic diversity of a non‐sulfide, low‐salt cold spring sediment of Shawan County, China

The prokaryotic diversity of a non‐sulfide, low‐salt cold spring sediment was investigated by constructing bacterial and archaeal clone libraries of the 16S rRNA gene. 241 bacterial clones were screened, which could be grouped into 86 ribotypes, based on restriction fragment length polymorphism (RFLP) analysis. These were divided into 11 phyla (Actinobacteria, Acidobacteria, Bacteroidetes, Chlorobi, Cyanobacteria, Firmicutes, Gemmatimonadetes, Nitrospirae, Proteobacteria, Planctomycetes and Verrucomicrobia). Of these, Acidobacteria and Proteobacteria were the most dominant, representing 48% and 25% of the total bacteria clone library, respectively. For the archaeal clone library, 121 positive clones were screened and 22 ribotypes were determined. BLAST analysis indicated that all ribotypes were affiliated with the phylum Crenarchaeota. Phylogenetic analysis classified them into three subgroups (Groups I–III). Groups I and III, belonging to the Soil–Freshwater‐subsurface group and Marine group I, respectively, were the dominant groups, representing 50% and 47% of the library, respectively. Of them, 20% of ribotypes were related to the cold‐loving Crenarchaeota. These findings show that bacteria in spring sediments are more diverse than are archaea; in addition, the spring harbors a large number of novel bacterial and archaeal species and maybe exist novel lineages. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Modifications of Generation tripping scheme of the 500 kV Comahue - Buenos Aires corridor

The 500kV Comahue - Buenos Aires corridor interconnects a remote exporting area (mostly hydroelectric generation) with the load center of Buenos Aires. In order to maximize power transfer limits of the corridor, an Automatic Generation Disconnection scheme (DAG) was developed for controlling post contingencies overloads and ensure transient and voltage stability, against single or double faults, called “DAG Comahue”.
NFC in cell phones: The new paradigm for an interactive world [Near-Field Communications]

Near-field communications (NFC) promises to create a whole new paradigm for the vast majority of cell phone users and is emerging as a near-term reality. What has been described as the confluence of RFID and cellular telephony will bring with it a wealth of new applications. The applications space, security mechanisms, and human interface are maturing; the service providers and payment companies are working to keep pace with these new capabilities; and it is starting to be incorporated into the new generation of cell phone designs. With NFC, our favorite electronic companion essentially becomes our magic wand. The basic ¿wand¿ premise is that it indicates intent. When you point, where you point, or at whom you point, tells the machine piece of the human-machine interface much about what it is supposed to do.
A Generic Strategy Framework for Policy-directed Autonomous Trading Agents

In this paper, a strategy framework for coordinating decentralized autonomous agents is presented and applied within a smart energy grid. The framework brings together the concept of policy-based computing and market-based coordination. In this context, agents can be seen as self-interested entities that are governed by their local policies. Effi- cient coordination between these self-interested agents is realized through a market me- chanism that incentivizes the agents to reveal their policies to the market. By knowing the agent's policies, an efficient solution for the overall system can be determined. Leveraging a declarative, policy-based approach facilities the specification of highly customizable strate- gies that can be easily adapted to various resources and markets. As an example for a real- world application, the framework is used for efficient balancing of decentralized energy supply (e.g. photovoltaic, wind power, CHP) and demand (e.g. households, businesses) in a power grid.
Speech Perception and Implicit Memory: Evidence for Detailed Episodic Encoding of Phonetic Events 1

Recent investigations into the nature of memory for spoken words have demonstrated that detailed, episodic information about the voice of the talker is encoded along with more abstract information about the linguistic content of an utterance. These findings present serious challenges to traditional views of speech perception, in which the process of abstraction plays a major role. We first outline the traditionalist view of speech perception, a theoretical framework largely based on the constructs of formal linguistics. Next, we elaborate the recently emerging “detailed encoding” view and summarize recent evidence from perceptual and memory experiments that demonstrate that “linguistic” and “extra-linguistic” information in spoken language are inseparable in the acoustic signal and in the representation of speech in long-term memory.
Position location of mobile terminal in wireless MIMO communication systems

A promising approach to improve the performance of mobile location system is the use of antenna arrays in both transmitter and receiver sides. Using advanced array signal processing techniques, such multiple-input multiple-output (MIMO) communication systems can offer more mobile location information by exploiting the spatial properties of the multipath channel. In this pa- per, we propose a novel approach to determine the position of mo- bile terminal based on estimated multipath signal parameters using only one base station in MIMO communication systems. This approach intends to minimize the error occurring from the estimation of multiple paths and gives an optimal estimation of the position of mobile terminal by simultaneously calculating a set of nonlinear location equations. This solution breaks the bottleneck of conventional mobile location systems which have to require multi-lateration of at least three base stations.
MHC Class II Polymorphisms, Autoreactive T-Cells, and Autoimmunity

Major histocompatibility complex (MHC) genes, also known as human leukocyte antigen genes (HLA) in humans, are the prevailing contributors of genetic susceptibility to autoimmune diseases such as Type 1 Diabetes (T1D), multiple sclerosis, and rheumatoid arthritis, among others (1–3). Although the pathways through which MHC molecules afford autoimmune risk or resistance remain to be fully mapped out, it is generally accepted that they do so by shaping the central and peripheral T-cell repertoires of the host toward autoimmune proclivity or resistance, respectively. Disease-predisposing MHC alleles would both spare autoreactive thymocytes from central tolerance and bias their development toward a pathogenic phenotype. Protective MHC alleles, on the other hand, would promote central deletion of autoreactive thymocytes and skew their development toward non-pathogenic phenotypes. This interpretation of the data is at odds with two other observations: that in MHC-heterozygous individuals, resistance is dominant over susceptibility; and that it is difficult to understand how deletion of one or a few clonal autoreactive T-cell types would suffice to curb autoimmune responses driven by hundreds if not thousands of autoreactive T-cell specificities. This review provides an update on current advances in our understanding of the mechanisms underlying MHC class II-associated autoimmune disease susceptibility and/or resistance and attempts to reconcile these seemingly opposing concepts.