Miracle-dz/UniFAR-FTUs huggingface dataset:
Experiences of physiotherapists working with adults living with Long COVID in Canada: a qualitative study

Objectives: To explore experiences of physiotherapists working with adults living with Long COVID in Canada. Design: Cross-sectional descriptive qualitative study involving online semi-structured interviews. Participants: We recruited physiotherapists in Canada who self-identified as having clinically treated one or more adults living with Long COVID in the past year. Data collection: Using an interview guide, we inquired about physiotherapists knowledge of Long COVID, assessment and treatment experiences, perspectives on physiotherapists roles, contextual and implementation factors influencing rehabilitative outcomes, and their recommendations for Long COVID rehabilitation. Interviews were audio-recorded, transcribed verbatim, and analyzed using a group-based thematic analytical approach. We administered a demographic questionnaire to describe sample characteristics. Results: Thirteen physiotherapists from five provinces participated; most were women (n=8;62%) and practised in urban settings (n=11;85%). Participants reported variable amounts of knowledge of existing guidelines and experiences working with adults living with Long COVID in the past year. Physiotherapists characterized their experiences working with adults living with Long COVID as a dynamic process involving: 1) a disruption to the profession (encountering a new patient population and pivoting to new models of care delivery), followed by 2) a cyclical process of learning curves and evolving roles of physiotherapists working with persons living with Long COVID (navigating uncertainty, keeping up with rapidly-emerging evidence, trial and error, adapting mindset and rehabilitative approaches, and growing prominence of roles as advocate and collaborator). Participants recommended the need for education and training, active and open-minded listening with patients, interdisciplinary models of care, and organizational- and system-level improvements to foster access to care. Conclusions: Physiotherapists experiences involved a disruption to the profession followed by a dynamic process of learning curves and evolving roles in Long COVID rehabilitation. Not all participants demonstrated an in-depth understanding of existing Long COVID rehabilitation guidelines. Results may help inform physiotherapy education in Long COVID rehabilitation.
Aspects that facilitate access to care for viral hepatitis: An evaluative research

ABSTRACT BACKGROUND: Viral hepatitis is a major public health concern worldwide. OBJECTIVES: This study aimed to analyze the factors that facilitate access to care for viral hepatitis. DESIGN AND SETTING: Using a sequential mixed method, this evaluation research was conducted in the state of Mato Grosso, Brazil. METHODS: Mapping of references and selection of regions were made based on the quantity and heterogeneity of services. The stakeholders, including the managers of the State Department of Health and professionals from reference services, were identified. Nine semi-structured interviews were conducted using content analysis and discussions guided by the dimensions of the analysis model of universal access to health services. RESULTS: In the political dimension, decentralizing services and adhering to the Intermunicipal Health Consortium are highly encouraged. In the economic-social dimension, a commitment exists to allocate public funds for the expansion of referral services and subsidies to support users in their travel for appointments, medications, and examinations. In the organizational dimension, the availability of inputs for testing, definition of user flow, ease of scheduling appointments, coordination by primary care in testing, collaboration following the guidelines and protocols, and engagement in extramural activities are guaranteed. In the technical dimension, professionals actively commit to the service and offer different opening hours, guarantee the presence of an infectious physician, expand training opportunities, and establish intersectoral partnerships. In the symbolic dimension, professionals actively listen to the experiences of users throughout their care trajectory and demonstrate empathy. CONCLUSIONS: The results are crucial for improving comprehensiveness, but necessitate managerial efforts to enhance regional governance.
Spatio-temporal evolution and driving factors of new urbanization in central China based on multi-source data

Urbanization is an inevitable outcome of the development of human society to a certain stage, and it is also an irreversible pattern of the concentration degree of human society. Based on multi-source data such as remote sensing images, ecological environment and socio-economic data, the evaluation index system of new urbanization is constructed from multi-dimensions of population, economy, society, space and ecology. To explore the spatio temporal evolution and driving factors of urbanization in 80 prefecture-level cities in central China from 2013 to 2021 by using entropy method, spatial autocorrelation model and geographic detector. The results show that: (1) The level of new urbanization continues to grow, with the average value rising from 0.1562 in 2013 to 0.2557 in 2021, and the regional differences are obvious, forming a circle structure with Wuhan, Zhengzhou and other provincial capitals as the center and weakening radiation to surrounding cities. (2) The agglomeration of ecological urbanization is significant, and the agglomeration trend is gradually enhanced. The high-high agglomeration areas tend to Xinzhou City, most prefecture-level cities in Hubei Province and some prefecture-level cities in Southern Hunan Province, while the low-low agglomeration areas tend to Changzhi City, most prefecture level cities in Henan Province and some prefecture-level cities in Northern Anhui Province. (3) The night light index, total retail sales of consumer goods, investment in fixed assets, proportion of built-up areas and urban economic density are the main driving factors affecting the level of new urbanization. (4) The interaction of driving factors shows double factor enhancement and nonlinear enhancement effects.
Longitudinal adherence to surveillance for late effects of cancer treatment: a population-based study of adult survivors of childhood cancer

Background: Adult survivors of childhood cancer are at elevated risk of morbidity and mortality compared to the general population, but their adherence to lifelong periodic surveillance is suboptimal. We aimed to examine adherence to surveillance guidelines for high-yield tests and identify risk factors for nonadherence in adult survivors of childhood cancer. Methods: In this retrospective, population-based cohort study, we used health care administrative data from Ontario, Canada, to identify adult survivors of childhood cancer diagnosed between 1986 and 2014 who were at elevated risk of therapy-related colorectal cancer, breast cancer, or cardiomyopathy. Using a Poisson regression framework, we assessed longitudinal adherence and predictors of adherence to the Children’s Oncology Group surveillance guideline. Results: Among 3241 survivors, 327 (10%), 234 (7%), and 3205 (99%) were at elevated risk for colorectal cancer, breast cancer, and cardiomyopathy, respectively. Within these cohorts, only 13%, 6%, and 53% were adherent to recommended surveillance as of February 2020. During a median follow-up of 7.8 years, the proportion of time spent adherent was 14% among survivors at elevated risk for colorectal cancer, 10% for breast cancer, and 43% for cardiomyopathy. Significant predictors of adherence varied across the risk groups, but higher comorbidity was associated with adherence to recommended surveillance. Interpretation: Survivors of childhood cancer in Ontario are rarely up to date for recommended surveillance tests. Tailored interventions beyond specialized clinics are needed to improve surveillance adherence.
High association strengths are linked to phenotypic similarity, including plumage color and patterns, of participants in mixed-species bird flocks of southwestern China

Abstract Participants in mixed-species bird flocks (MSFs) have been shown to associate with species that are similar in body size, diet, and evolutionary history, suggesting that facilitation structures these assemblages. In addition, several studies have suggested that species in MSFs resemble each other in their plumage, but this question has not been systematically investigated for any MSF system. During the nonbreeding season of 2020 and 2021, we sampled 585 MSFs on 14 transects in 2 habitats of Tongbiguang Nature Reserve in western Yunnan Province, China. We performed social network analysis and the Multiple Regression Quadratic Assignment Procedure to evaluate the effect of 4 species traits (body size, overall plumage color, distinctive plumage patterns, and diet) and evolutionary history on species association strength at the whole-MSF and within-MSF levels. All 41 significant relationships showed that species with stronger associations were more similar in their various traits. Body size had the strongest effect on association strength, followed by phylogeny, plumage patterns, and plumage color; diet had the weakest effect. Our results are consistent with the hypotheses that the benefits of associating with phenotypically similar species outweigh the potential costs of interspecific competition, and that trait matching can occur in plumage characteristics, albeit more weakly than in other traits. Several explanations exist as to why similarities in plumage may occur in MSFs, including that they could reduce predators’ ability to target phenotypically “odd” individuals. Whether trait matching in plumage occurs through assortative processes in ecological time or is influenced by co-evolution requires further study.
Outcomes of critically ill patients with liver failure who require mechanical ventilation: A retrospective, single‐center study

Abstract Background and Aims Critically ill patients with liver failure have high mortality. Besides the management of organ‐specific complications, liver transplantation constitutes a definitive treatment. However, clinicians may hesitate to introduce mechanical ventilation for patients on liver transplantation waitlists because of poor prognosis. This study investigated the outcomes of intensive care and ventilation support therapy effects in patients with liver failure. Methods This single‐center study retrospectively enrolled 32 consecutive patients with liver failure who were admitted to the intensive care unit from January 2014 to December 2020. The medical records were reviewed and analyzed retrospectively for Acute Physiologic and Chronic Health Evaluation (APACHE)‐II. The model for end‐stage liver disease scores, 90‐day mortality, and survival was assessed using the Kaplan–Meier method. Results The average patient age was 45.5 ± 20.1 years, and 53% of patients were women. On intensive care unit admission, APACHE‐II and model for end‐stage liver disease scores were 20 and 28, respectively. Among 13 patients considered for liver transplantation, 4 received transplants. Thirteen patients (40.6%) were intubated and mechanically ventilated in the intensive care unit. The 90‐day mortality rate of patients with and without mechanical ventilation in the intensive care unit (13, 61.5% vs. 19, 47.4%, p = 0.4905) was similar. APACHE‐II score >21 was an independent predictor of mechanical ventilation requirement in patients with liver failure during intensive care unit stay. Conclusion Although critically ill patients with liver failure are at risk of multiorgan failure with poor outcomes, mechanical ventilation did not negatively affect the 90‐day mortality or performance rates of liver transplantation. Clinicians should consider mechanical ventilation‐based life support in critically ill patients with liver failure who are awaiting liver transplantation.
How current law and policy supports providers of NHS healthcare in England to respond to patient harm: A scoping review protocol

Introduction Harm arising from National Health Service (NHS) healthcare results in significant human cost for the patient, those who care for them, and the medical staff involved. Furthermore, patient harm results in substantial financial costs to the public purse. Improving how NHS providers in England respond to patient harm could reduce the number of claims for clinical negligence brought against NHS. Doing so will ensure those affected receive the justice they deserve and protect the public purse. Law and policy are key to supporting providers of NHS healthcare to respond to patient harm but are not necessarily understood and therefore can be challenging to apply to practice. Research exploring how law and policy supports this understanding is limited. The purpose of this scoping review is to address this knowledge gap and improve understanding by critically evaluating how law and policy supports providers of NHS healthcare in England to respond to patient harm. Methods and analysis The review will use the methodological framework proposed by Arskey and O’Malley, Levac et al and the Joanna Briggs Institute. Search strategies will be developed using selected key words and index terms. MEDLINE, CINAHL, and Westlaw and reference lists of relevant publications will be searched to identify relevant grey literature. Two reviewers will independently assess the extracted data against the eligibility criteria. All studies identified will be charted and the results presented as a narrative synthesis.
Land Use Change Sustainability and Carbon Turnover Rate in the Northern Great Plains Soil

LAND USE CHANGE SUSTAINABILITY AND CARBON TURNOVER RATE IN THE NORTHERN GREAT PLAINS SOIL DEEPAK R. JOSHI 2018 Sustainable land management involves the management of land, water, biodiversity and other resources that meet human requirements while maintaining ecosystem services. In the northern Great Plains (NGP), the combined impacts of landuse and climate variability have placed many soils at the tipping point of sustainability. The objectives of this study were to: 1) calculate land-use changes from 2006 to 2012 and from 2012 to 2014 in South Dakota and Nebraska; 2) assess if land use changes had impacted on soil sustainability; 3) calculate variation in total carbon budget and turnover due to seasonal climate variability, biomass quality and soil properties; and 4) determine effect of fire and on the CO2 emissions, soil temperature and soil moisture. For South Dakota and Nebraska, 43,200 and 38,400 points, respectively were visually classified from high resolution imagery in 2006, 2012, and 2014 into five different categories (cropland, grassland, Habitat, NonAg, and Water). From 2006 to 2014, 910,000 million hectares were converted from grassland to cropland in South Dakota and 360,000 hectares were converted from grassland to cropland in Nebraska. In South Dakota, approximately 92% of the land-use changes occurred on land suitable for crop production (Land Capability Class, LCC ≤4), whereas in Nebraska 80% of the land-use
Experiential-sensorial adaptive system model for hospitality based on 360° VR videos and case-based reasoning

In this work, an adaptive software architecture is proposed for the generation of experiences for hotel promotion and marketing, based on Case-based Reasoning (CBR) that uses the attributes and user characteristics and immersive 360° videos. Considering that immersion in virtual reality (VR) environments can trigger responses in various dimensions, such as affective, cognitive, attitudinal, and behavioral dimensions, these dimensions are evaluated in immersive environments with 360° videos. To validate the results obtained with the software architecture, a quasi-experimental study was conducted through the evaluation of the experience, consisting in the visualization of the environments of a boutique hotel, with a sample of a randomly selected group of young people. The contribution of this work lies in the use of 360° VR videos, for the visualization of the hotel characteristics and environments according the user profiles, to evaluate the affective, cognitive and attitudinal and behavioral responses and their influence on the booking intention and attitude. Finally, conclusions and recommendations for future work have been established.
Pediatric Hip Dysplasia Surgery Outcomes by Pediatric Versus Nonpediatric Orthopedists

Objectives Developmental dysplasia of the hip (DDH) encompasses a spectrum of abnormalities in the immature hip. Surgical intervention is indicated if conservative management fails. Despite the increased supply of pediatric orthopedic surgeons (POSs) over the last few decades, there continues to be a maldistribution of surgeons. The purpose of this study is to determine outcomes following surgical management of hip dysplasia by POSs compared to non-pediatric orthopedic surgeons. Methods Pediatric patients who underwent surgical treatment for hip dysplasia from 2012 to 2019 were identified using a large national database. Patient demographics, comorbidities, and postoperative complications were compared by pediatric versus nonpediatric-trained orthopedic surgeons. Bivariate and multivariable regression analyses were performed. Results Of the 10,780 pediatric patients who underwent hip dysplasia surgery, 10,206 patients (94.7%) were operated on by a POS, whereas 574 (5.3%) were operated on by a non-pediatric orthopedic surgeon. POSs were more likely to operate on patients with a higher American Society of Anesthesiologists class (p<0.001) and those with a greater number of medical comorbidities, including cardiac (p=0.001), gastrointestinal (p=0.017), and neurological (p<0.001). Following analysis using multivariable regression models to control for patient baseline characteristics, there were no differences in any postoperative complications between patients treated by pediatric-trained and nonpediatric-trained orthopedic surgeons. Conclusions Compared to non-pediatric orthopedic surgeons, POSs were more likely to operate on younger patients with increased medical comorbidities. However, there were no differences in postoperative complications following surgical management for DDH in patients treated by nonpediatric and pediatric orthopedic surgeons.
Combinatorial expression of γ-protocadherins regulates synaptic connectivity in the mouse neocortex

In the process of synaptic formation, neurons must not only adhere to specific principles when selecting synaptic partners but also possess mechanisms to avoid undesirable connections. Yet, the strategies employed to prevent unwarranted associations have remained largely unknown. In our study, we have identified the pivotal role of combinatorial clustered protocadherin gamma (γ-PCDH) expression in orchestrating synaptic connectivity in the mouse neocortex. Through 5' end single-cell sequencing, we unveiled the intricate combinatorial expression patterns of γ-PCDH variable isoforms within neocortical neurons. Furthermore, our whole-cell patch-clamp recordings demonstrated that as the similarity in this combinatorial pattern among neurons increased, their synaptic connectivity decreased. Our findings elucidate a sophisticated molecular mechanism governing the construction of neural networks in the mouse neocortex.
Petrogenesis of the Large-volume Cardones Ignimbrite, Chile; Development and Destabilization of a Complex Magma–Mush System

The 21.9 Ma Cardones ignimbrite, a member of the early Miocene Oxaya Formation in northernmost Chile, is a crystal-rich (ca. 40 vol%) rhyolite with an extra-caldera thickness up to 1000 m. Access to core from eight ca. 1 km drill holes enabled sampling and petrological characterisation of pumice throughout the entire thickness of the ignimbrite at an unprecedented range of spatial scales. Mineral chemistry and modes reveal the presence of sanidine-poor and sanidine-rich pumice types, representing two, petrologically distinct magmas with the former being hotter (850-750°C) than the latter (770-670C). The sanidine-poor magma is amphibolebearing and has a Ba-rich melt phase (400-1000 ppm), whereas the sanidine-rich magma has a Ba-poor melt phase (<200 ppm) and lacks amphibole. Thermobarometry of antecrystal remnants in the sanidine-poor pumice clasts indicate derivation of rhyodacitic melts from a middle crustal hot zone (950-850°C) where wet, intermediate to mafic magmas stalled and fractionated. Textures and zoning in zircon and plagioclase are consistent with the interpretation that rhyodacitic melts were episodically emplaced into the shallow crust at 6.0 to 8.7 ± 2.0 km depths over a period of ca. 200 ky. Sanidine-rich magma compositions are consistent with the melt phase in the sanidine-poor magma, hence the former could be derived by residual melt segregation from the latter. High-Ba and high-Sr zones in sanidine have compositions up to 28,000 ppm and 400 ppm respectively. Such high concentrations require input of more intermediate magmas and/or partial melting of cumulative magmas. The sanidine-rich magmas likely formed above of the sanidine-poor magmas. However, there is no systematic relationship between the different pumice types and the ignimbrite stratigraphy, suggesting major pre-eruptive destabilisation of the magmatic system led to the amalgamation and mixing of different, meltdominated lenses and surrounding crystal-mush to form a large heterogeneous eruptible magma body.
Amphibious surface-wave phase-velocity measurements of the Cascadia subduction zone

A new amphibious seismic data set from the Cascadia subduction zone is used to characterize the lithosphere structure from the Juan de Fuca ridge to the Cascades backarc. These seismic data are allowing the imaging of an entire tectonic plate from its creation at the ridge through the onset of the subduction to beyond the volcanic arc, along the entire strike of the Cascadia subduction zone. We develop a tilt and compliance correction procedure for ocean-bottom seismometers that employs automated quality control to calculate robust station noise properties. To elucidate crust and upper-mantle structure, we present shoreline-crossing Rayleigh-wave phase-velocity maps for the Cascadia subduction zone, calculated from earthquake data from 20 to 160 s period and from ambient-noise correlations from 9 to 20 s period. We interpret the phase-velocity maps in terms of the tectonics associated with the Juan de Fuca plate history and the Cascadia subduction system. We find that thermal oceanic plate cooling models cannot explain velocity anomalies observed beneath the Juan de Fuca plate. Instead, they may be explained by a ≤1 per cent partial melt region beneath the ridge and are spatially collocated with patches of hydration and increased faulting in the crust and upper mantle near the deformation front. In the forearc, slow velocities appear to be more prevalent in areas that experienced high slip in past Cascadia megathrust earthquakes and generally occur updip of the highest-density tremor regions and locations of intraplate earthquakes. Beneath the volcanic arc, the slowest phase velocities correlate with regions of highest magma production volume.