Miracle-dz/UniFAR-FTUs huggingface dataset:
Mutation spectrum of COL1A1 and COL1A2 genes in Indian patients with osteogenesis imperfecta

Osteogenesis imperfecta (OI) is a condition of decreased bone density with heterogeneous etiologies. Most of the cases are inherited in an autosomal dominant fashion and are caused by mutations in the COL1A1 or COL1A2 genes. Since these two genes are very large, there are no data about mutations in Indian patients with OI. We selected 35 Indian patients who were clinically diagnosed with OI and all exons of both the genes were sequenced. Mutations in COL1A1 (14 cases, 6 novel) and COL1A2 (11 cases, 7 novel) were identified in 25 patients. A total of 55 polymorphisms were identified in both the genes with eight novel variants in the coding region, and nine novel variants in the non‐coding regions. No mutation was detected in 10 patients. Six of them were from consanguineous families, with one or two similarly affected siblings suggesting possible autosomal recessive inheritance. If we exclude families with consanguinity, mutations were identified in 25 out of 29 families giving 86% mutation detection rate. Mutations in COL1A1 accounted for 56% of the cases and COL1A2 44%, which is similar to the reported rate worldwide. © 2014 Wiley Periodicals, Inc.
On the Clustered Shortest-Path Tree Problem

Given an n-vertex and m-edge non-negatively real-weighted graph G = (V, E, w), whose vertices are partitioned into a set of k clusters, a clustered network design problem on G consists of finding a (possibly optimal) solution to a given network design problem on G, subject to some additional constraint on its clusters. In this paper, we focus on the classic shortest-path tree problem and summarize our ongoing work in this field. In particular, we analyze the hardness of a clustered version of the problem in which the additional feasibility constraint consists of forcing each cluster to form a (connected) subtree.
Workgroup Report: Workshop on Source Apportionment of Particulate Matter Health Effects—Intercomparison of Results and Implications

Although the association between exposure to ambient fine particulate matter with aerodynamic diameter < 2.5 μm (PM2.5) and human mortality is well established, the most responsible particle types/sources are not yet certain. In May 2003, the U.S. Environmental Protection Agency’s Particulate Matter Centers Program sponsored the Workshop on the Source Apportionment of PM Health Effects. The goal was to evaluate the consistency of the various source apportionment methods in assessing source contributions to daily PM2.5 mass–mortality associations. Seven research institutions, using varying methods, participated in the estimation of source apportionments of PM2.5 mass samples collected in Washington, DC, and Phoenix, Arizona, USA. Apportionments were evaluated for their respective associations with mortality using Poisson regressions, allowing a comparative assessment of the extent to which variations in the apportionments contributed to variability in the source-specific mortality results. The various research groups generally identified the same major source types, each with similar elemental makeups. Intergroup correlation analyses indicated that soil-, sulfate-, residual oil-, and salt-associated mass were most unambiguously identified by various methods, whereas vegetative burning and traffic were less consistent. Aggregate source-specific mortality relative risk (RR) estimate confidence intervals overlapped each other, but the sulfate-related PM2.5 component was most consistently significant across analyses in these cities. Analyses indicated that source types were a significant predictor of RR, whereas apportionment group differences were not. Variations in the source apportionments added only some 15% to the mortality regression uncertainties. These results provide supportive evidence that existing PM2.5 source apportionment methods can be used to derive reliable insights into the source components that contribute to PM2.5 health effects.
The Nurse’s Role in Promoting Optimal Health of Older Adults: Thriving in the Wisdom Years

Thriving in Old Age What Does it Mean to 'Age Successfully'? Midrange Theory of Successful Aging Understanding Older Adults Opportunities and Challenges of Growing Old An Interprofessional Approach to Optimal Wellness Engaging Older Adults as Partners in Their Care Optimizing Physical Health & Functioning National Priorities Regarding the Health of Older Adults Common Disorders of the Older Population Assessing the Older Adult: What's Different? Staying Physically Fit as We Age Assistive Technology to Optimize Physical Functioning Intimacy Healthy Eating Using Medications Safely and Effectively Optimizing Economic and Social Well-Being Financial Resources Living Safely in the Environment Legal Considerations Family Caregiving Considering Diversity Considering Older Adults from Varied Perspectives Staying Connected Psychologically, Socially and Cognitively Optimizing Mental Well-Being and Spiritual Fulfillment Challenges to Mental Wellness Spirituality in Aging Planning for the End of Life.
The Relationship between Self-Aggrandizement and Self-Esteem in Japanese and American University Students

"Better than average" self-evaluations co-occur with and are generally accepted as evidence of high self-esteem in North Americans, and this pattern has been viewed as universal. But studies in Japan have consistently failed to find high self-esteem and self-aggrandizement, leading some to question whether the tendency to self-aggrandize in the service of self-esteem is indeed universal. Seventy-two Japanese and 110 American college students assessed themselves in terms of overall competence relative to same-sex peers, and their self-feelings (positive, negative, or mixed), and also completed the Rosenberg Self-Esteem Scale. In both groups, evaluations of the self as better than average were associated with positive self-feelings and higher self-esteem, and evaluations of the self as worse than average were associated with negative self-feelings and lower self-esteem. However, the two groups differed in how they felt about being just average. In absolute terms, the Americans, but not the Japanese, felt bad about themselves and had lower self-esteem when they viewed themselves as average. In both groups however, "average" students felt worse about themselves and had lower selfesteem than above average students. The American participants in general described themselves in highly positive terms, while the Japanese participants described themselves in balanced terms. Key Word: self-esteem, self-aggrandizement, averageness Feeling good about oneself has been described as an American cultural imperative by Markus and Kitayama (2003), and as a universal human need or motivation by an extensive list of eminent observers of the human condition, dating back to Thomas Hobbes, if not earlier (see Pajares & Schunk, 2002, Rosenberg, 1989 Rosenberg, Schooler, & Schoenbach, 1989 for historical perspective). Much speculation and research has gone into explaining what purpose this otherwise mysterious need serves. One influential theory claims that self-esteem functions as a monitor of one's fitness for inclusion in relationships (Leary, Tambor, Terdal, & Downs, 1995). That theory's primary competitor claims that self-esteem acts as a buffer against existential anxiety (Pyszcynski, Greenberg, Solomon, Arndt, & Schimel, 2004). But whatever purpose self-esteem serves, it is quite clear that people seek to have, and do in fact have, self-esteem in abundance (Baumeister, Campbell, Krueger, & Vohs, 2003). It has been well documented that people will attempt to create conditions that will allow them to feel good about themselves. They will also cognitively distort reality, if nec-1文教大学情報学部『情報研究』第35号 2006年7月 The Relationship between Self-Aggrandizement and Self-Esteem in Japanese and American University Students R.A. Brown Brown-self-aggrandize. 06.9. 26 11:51 AM ページ1
New approach for the skeletonization of handwritten characters in gray-scale images

Existing skeletonization methods operate directly onthe binary image ignoring the gray-level information.In this paper we propose a new method for the skeletonization of handwritten characters that uses gray-level information and capitalizes on their elongatedpattern properties. The method controls the development of the skeleton while iteratively binarizing thegray-level image. Two types of iterations are performed: the iterative skeletonization and deletion ofboundary pixels, which is nested within the iterativebinarization of the gray-level image. Detailed analysis of the skeletonization process is presented to showits superior performance related to the prevention of"flooding water" and end point shrinkage and to noiseimmunity.
Handbook of parent training : helping parents prevent and solve problem behaviors

Preface. Acknowledgments. Contributors. Introduction. PART ONE PREVENTION. 1 Preventive Parent Training with Low-Income, Ethnic Minority Families of Preschoolers (Deborah Gross, Christine Garvey, Wrenetha A. Julion, and Louis Fogg). 2 New Beginnings: An Empirically-Based Program to Help Divorced Mothers Promote Resilience in Their Children (Sharlene Wolchik, Irwin Sandler, Lillie Weiss, and Emily Winslow). PART TWO DEVELOPMENTAL DISORDERS. 3 Comprehensive Programs for Families of Children with Autism (Monica Campbell and Martin Kozloff). 4 Parent Management Training to Improve Competence in Parents of Children with Asperger Syndrome (Kate Sofronoff and Koa Whittingham). PART THREE INTERNALIZING DISORDERS. 5 Behavioral Family Intervention for Childhood Anxiety (Paula Barrett and Lara Farrell). 6 Parent Training in the Treatment of School Refusal Behavior (Christopher A. Kearney, Marcus T. LaSota, Amie Lemos-Miller, and Jennifer Vecchio). PART FOUR EXTERNALIZING DISORDERS. 7 The Triple P-Positive Parenting Program: A Public Health Approach to Parenting Support (Matthew R. Sanders). 8 Parent-Child Interaction Therapy with Physically Abusive Families (Amy D. Herschell and Cheryl B. McNeil). 9 Success-Based, Noncoercive Treatment of Oppositional Behavior (Joseph M. Ducharme). 10 Tailoring the Incredible Years Parent Programs according to Children's Developmental Needs and Family Risk Factors (Carolyn Webster-Stratton). 11 Training Parents of Children with Comorbid Attention-Deficit/Hyperactivity Disorder and Oppositional Defiant Disorder (Jeffrey S. Danforth). 12 Working with Parents of Aggressive, School-Age Children(Timothy A. Cavell and L. Christian Elledge). PART FIVE OTHER COMMON CHILDHOOD DISORDERS. 13 Home-Based Treatment for Primary Enuresis (Michael W. Mellon and Arthur C. Houts). 14 Parent Training for Parents of Adolescents with Substance Use and Delinquent Behavior Problems (Steven A. Branstetter, Joshua Masse, and Lisa Greene). Author Index. Subject Index.
Mouse model implicates GNB3 duplication in a childhood obesity syndrome

Significance We describe a genomic disorder that causes obesity, intellectual disability, and seizures. Children with this syndrome carry an unbalanced chromosome translocation that results in the duplication of over 100 genes, including G protein β3 (GNB3). Although GNB3 polymorphisms have been associated with obesity, hypertension, and diabetes, the mechanism of GNB3 pathogenesis is unknown. We created a transgenic mouse model that carries a duplication of GNB3, weighs significantly more than wild-type mice, and has excess abdominal fat. GNB3 is highly expressed in the brain and may be important for signaling related to satiety and/or metabolism. Obesity is a highly heritable condition and a risk factor for other diseases, including type 2 diabetes, cardiovascular disease, hypertension, and cancer. Recently, genomic copy number variation (CNV) has been implicated in cases of early onset obesity that may be comorbid with intellectual disability. Here, we describe a recurrent CNV that causes a syndrome associated with intellectual disability, seizures, macrocephaly, and obesity. This unbalanced chromosome translocation leads to duplication of over 100 genes on chromosome 12, including the obesity candidate gene G protein β3 (GNB3). We generated a transgenic mouse model that carries an extra copy of GNB3, weighs significantly more than its wild-type littermates, and has excess intraabdominal fat accumulation. GNB3 is highly expressed in the brain, consistent with G-protein signaling involved in satiety and/or metabolism. These functional data connect GNB3 duplication and overexpression to elevated body mass index and provide evidence for a genetic syndrome caused by a recurrent CNV.
A Numerical Study of the Nonlinear Reaction-Diffusion Equation with Different Type of Absorbent Term by Homotopy Analysis Method

In this paper, based on the homotopy analysis method (HAM), a new powerful algorithm is used for the solution of the nonlinear reaction-diffusion equation. The algorithm presents the procedure of constructing a set of base functions and gives the high-order deformation equation in a simple form. Different from all other analytic methods, it provides us with a simple way to adjust and control the convergence region of the solution series by introducing an auxiliary parameter h. The solutions of the problem of presence and absence of absorbent term and external force for different particular cases are presented graphically.
A Biological-Realtime Neuromorphic System in 28 nm CMOS Using Low-Leakage Switched Capacitor Circuits

A switched-capacitor (SC) neuromorphic system for closed-loop neural coupling in 28 nm CMOS is presented, occupying 600 um by 600 um. It offers 128 input channels (i.e., presynaptic terminals), 8192 synapses and 64 output channels (i.e., neurons). Biologically realistic neuron and synapse dynamics are achieved via a faithful translation of the behavioural equations to SC circuits. As leakage currents significantly affect circuit behaviour at this technology node, dedicated compensation techniques are employed to achieve biological-realtime operation, with faithful reproduction of time constants of several 100 ms at room temperature. Power draw of the overall system is 1.9 mW.
FAR-RED ELONGATED HYPOCOTYL3 activates SEPALLATA2 but inhibits CLAVATA3 to regulate meristem determinacy and maintenance in Arabidopsis

Significance The transcription factor FAR-RED ELONGATED HYPOCOTYL3 (FHY3) is known to play multiple roles at the vegetative stage in Arabidopsis, but its functions in reproductive stage are unclear. We find that FHY3 is required for floral meristem determinacy and shoot apical meristem maintenance by mainly acting as a transcriptional repressor. FHY3 mediates light-regulated CLAVATA3 expression to regulate WUSCHEL expression in shoot apical meristem and directly represses CLAVATA3, but activates SEPALLATA2, to promote floral meristem determinacy. Furthermore, FHY3 may coregulate flower development with three flower-specific MADS-domain transcription factors and four basic helix–loop–helix transcription factors that are involved in photomorphogenesis, and thus may act as a bridge molecule in the cross-talk between external signals and endogenous cues to coordinate plant development. Plant meristems are responsible for the generation of all plant tissues and organs. Here we show that the transcription factor (TF) FAR-RED ELONGATED HYPOCOTYL3 (FHY3) plays an important role in both floral meristem (FM) determinacy and shoot apical meristem maintenance in Arabidopsis, in addition to its well-known multifaceted roles in plant growth and development during the vegetative stage. Through genetic analyses, we show that WUSCHEL (WUS) and CLAVATA3 (CLV3), two central players in the establishment and maintenance of meristems, are epistatic to FHY3. Using genome-wide ChIP-seq and RNA-seq data, we identify hundreds of FHY3 target genes in flowers and find that FHY3 mainly acts as a transcriptional repressor in flower development, in contrast to its transcriptional activator role in seedlings. Binding motif-enrichment analyses indicate that FHY3 may coregulate flower development with three flower-specific MADS-domain TFs and four basic helix–loop–helix TFs that are involved in photomorphogenesis. We further demonstrate that CLV3, SEPALLATA1 (SEP1), and SEP2 are FHY3 target genes. In shoot apical meristem, FHY3 directly represses CLV3, which consequently regulates WUS to maintain the stem cell pool. Intriguingly, CLV3 expression did not change significantly in fhy3 and phytochrome B mutants before and after light treatment, indicating that FHY3 and phytochrome B are involved in light-regulated meristem activity. In FM, FHY3 directly represses CLV3, but activates SEP2, to ultimately promote FM determinacy. Taken together, our results reveal insights into the mechanisms of meristem maintenance and determinacy, and illustrate how the roles of a single TF may vary in different organs and developmental stages.
EnCore: private, context-based communication for mobile social apps

Mobile social apps provide sharing and networking opportunities based on a user's location, activity, and set of nearby users. A platform for these apps must meet a wide range of communication needs while ensuring users' control over their privacy. In this paper, we introduce EnCore, a mobile platform that builds on secure encounters between pairs of devices as a foundation for privacy-preserving communication. An encounter occurs whenever two devices are within Bluetooth radio range of each other, and generates a unique encounter ID and associated shared key. EnCore detects nearby users and resources, bootstraps named communication abstractions called events for groups of proximal users, and enables communication and sharing among event participants, while relying on existing network, storage and online social network services. At the same time, EnCore puts users in control of their privacy and the confidentiality of the information they share. Using an Android implementation of EnCore and an app for event-based communication and sharing, we evaluate EnCore's utility using a live testbed deployment with 35 users.
Addressing Challenges in Doing International Field Research

This panel will discuss some of the key challenges in doing international field research including issues with planning, conducting, interpreting, and reporting on such research. Panelists will also share potential solutions and approaches they have used to try to deal with these challenges, and will discuss with the audience additional challenges that audience members have encountered, offering ideas on how to address these as appropriate.
DECODING OF CHILDREN'S NONVERBAL FACIAL EXPRESSIONS OF EMOTION BY PARENTS AND NONPARENTS

Decoding of Children's Nonverbal Facial Expressions of Emotion by Parents and Nonparents September, 198 2 Joel Alan Feinman, B.A., State University of New York at Buffalo M.S., Ph.D., University of Massachusetts Directed by: Professor Robert S. Feldman Parents' abilities to decode their children's nonverbal expressions of four affects (happiness, sadness, fear, and anger) were contrasted with the decoding abilities of a matched group of nonparents. No differences were found between parents' and nonparents' decoding abilities. However, decoding abilities were found to vary as a function of the sex of the encoding child and, the type of affect expressed. Female children were found to be more accurate encoders of spontaneous affective expressions than male children. Of the four affects studied, communication accuracy was found to be highest for expressions of sadness and lowest for expressions of anger. Several hypotheses, including the differential effect of socialized display rules on male and female children, are discussed to explain the
A 32-Mb SPRAM With 2T1R Memory Cell, Localized Bi-Directional Write Driver and `1'/`0' Dual-Array Equalized Reference Scheme

A 32-Mb SPin-transfer torque RAM (SPRAM) chip was demonstrated with an access time of 32 ns and a cell write-time of 40 ns at a supply voltage of 1.8 V. The chip was fabricated with 150-nm CMOS and a 100 × 200-nm tunnel magneto-resistive (TMR) device element. A required thermal stability of 67 of the TMR device was estimated by taking into account the disturbances during read operations and data retention periods of 10 years for nonvolatile operation. The 32-Mb SPRAM chip features three circuit technologies suitable for a large-scale array: 1) a two-transistor, one-resistor (2T1R) type memory cell for achieving a sufficiently large write current despite the small cell size, 2) a compact read/write separated hierarchy bit/source-line structure with a localized bi-directional write driver for efficiently distributing write current, and 3) a '1'/'0' dual-array equalized reference scheme for stable read operation.
PENERAPAN BALANCED SCORECARD SEBAGAI TOLOK UKUR PENILAIAN PADA BADAN USAHA BERBENTUK KOPERASI

engukuran kinerja merupakan salah satu faktor yang amat penting bagi perusahaan. Pengukuran tersebut, misalnya, dapat digunakan untuk menilai keberhasilan perusahaan serta sebagai dasar penyusunan imbalan dalam perusahaan. Selama ini, pengukuran kinerja secara tradisional hanya menitikberatkan pada sisi keuangan. Manajer yang berhasil mencapai tingkat keuntungan atau Return on Investment yang tinggi akan dinilai berhasil, dan memperoleh imbalan yang baik dari perusahaan. Akan tetapi, menilai kinerja perusahaan semata-mata dari aspek keuangan dapat menyesatkan. Kinerja keuangan yang baik saat ini kemungkinan dicapai dengan mengorbankan kepentingan-kepentingan jangka panjang perusahaan. Dan sebaliknya, kinerja keuangan yang kurang baik dalam jangka pendek dapat terjadi karena perusahaan melakukan investasi-investasi demi kepentingan jangka panjang perusahaan. Mengatasi kekurangan ini, ditambah dengan kenyataan betapa aktiva perusahaanperusahaan di era informasi ini lebih didominasi oleh intangible assets yang tak terukur, dicobalah pendekatan baru yang mengukur kinerja perusahaan dengan mempertimbangkan empat aspek atau perspektif, yakni perspektif keuangan, pelanggan, proses bisnis internal, serta proses belajar dan berkembang. Keempat perspektif tersebut merupakan uraian dan upaya penerjemahan visi dan strategi perusahaan ke dalam terminologi operasional (Kaplan dan Norton, 1996). Gagasan untuk menyeimbangkan pengukuran aspek keuangan dengan aspek non keuangan melahirkan apa yang dinamakan Balanced Scorecard. Pada era kompetisi yang berlandaskan pengetahuan (knowledge-based competition), kemampuan organisasi untuk