Miracle-dz/UniFAR-FTUs huggingface dataset:
Progressive DNA and RNA damage from oxidation after aneurysmal subarachnoid haemorrhage in humans

Abstract Free radical toxicity is considered as a key mechanism in the neuronal damage occurring after aneurysmal subarachnoid haemorrhage (SAH). We measured markers of DNA and RNA damage from oxidation (8-oxodG and 8-oxoGuo, respectively) in cerebrospinal fluid from 45 patients with SAH on day 1–14 after ictus and 45 age-matched healthy control subjects. At baseline, both markers were significantly increased in patients compared to controls (p values < .001), and exhibited a progressive further increase (to >20-fold above control levels) from day 5–14. None of the markers predicted the occurrence of vasospasms or mortality, although there was a trend that the 8-oxoGuo marker was more strongly associated with mortality than the 8-oxodG marker. We conclude that SAH leads to a massive increase in damage to nucleic acids from oxidative stress, which is likely to play a role in neuronal dysfunction and death. As only patients in need of a ventriculostomy catheter were included in the study, the findings cannot necessarily be extrapolated to all patients with SAH.
Silver Nanoparticles in the Lung: Toxic Effects and Focal Accumulation of Silver in Remote Organs

The distribution of silver (Ag) into remote organs secondary to the application of Ag nanoparticles (Ag-NP) to the lung is still incompletely understood and was investigated in the rat with imaging methods. Dose-finding experiments were carried out with 50 nm- or 200 nm-sized polyvinyl pyrrolidine (PVP)-coated Ag-NP using alveolar macrophages in vitro and female rats, which received Ag-NP via intratracheal instillation. In the main study, we administered 37.5–300 µg per rat lung of the more toxic Ag50-PVP and assessed the broncho-alveolar lavage fluid (BALF) for inflammatory cells, total protein and fibronectin after three and 21 days. In parallel, lung tissue was analysed for DNA double-strand breaks and altered cell proliferation. While 75–150 µg Ag50-PVP per rat lung caused a reversible inflammation, 300 µg led to DNA damage, accelerated cell proliferation and progressively increasing numbers of neutrophilic granulocytes. Ag accumulation was significant in homogenates of liver and other peripheral organs upon lung dose of ≥75 µg. Quantitative laser-ablation inductively-coupled plasma mass spectrometry (LA-ICP-MS) combined with enhanced dark field microscopy and autometallography revealed focal accumulations of Ag and/or Ag-NP in sections of peripheral organs: mediastinal lymph nodes contained Ag-NP especially in peripheral macrophages and Ag in argyrophilic fibres. In the kidney, Ag had accumulated within proximal tubuli, while renal filter structures contained no Ag. Discrete localizations were also observed in immune cells of liver and spleen. Overall, the study shows that concentrations of Ag-NP, which elicit a transient inflammation in the rat lung, lead to focal accumulations of Ag in peripheral organs, and this might pose a risk to particular cell populations in remote sites.
Detection and Prevention of ARP spoofing using Centralized Server

Address Resolution Protocol (ARP) due to its statelessness and lack of an authentication mechanism for verifying the identity of the sender has a long history of being prone to spoofing attacks. ARP spoofing is sometimes the starting point for more sophisticated LAN attacks like denial of service, man in the middle and session hijacking. In a current voting based method an active technique is used for finding out the legitimate one by collection of voting's from the neighboring host. The drawback of this system is most of the host in a LAN must follow the MR-ARP protocol. In this paper a centralized server will collects all the ip-mac pairs of every host in the LAN and maintains a table of legitimate host. Destination host checks the ip-mac conflict in the LAN and informs about the hacker to the centralized server which takes care of the trusted communication between the participating hosts. Hence, the proposed work detection and prevention of ARP spoofing lead to appreciable result. Keywordsprotocol, MAC address, IP address, router, spoofing
Pseudoelasticity and shape memory effects in alloys

AbstractTransformation pseudoelasticity and shape memory effects in alloys are reviewed on an introductory to intermediate level — the review is not intended to be exhaustive. What pseudoelasticity and shape memory effects are and how such phenomena arise, are described in simple terms in the introduction. The stress induced martensitic transformation is then discussed in some detail from both the crystallographic and thermodynamic aspects, including successive stress induced martensitic transformations. Transformation pseudoelasticity, orientation dependence, temperature dependence, and strain rate dependence are described. The shape memory effect is discussed in some detail, emphasis being placed on the deformation mechanism of martensites and the origin of the one-way and two-way memory effects. Finally, a short description is given on recent advances in the application of those effects.
The localization and phosphorylation of p47 are important for Golgi disassembly–assembly during the cell cycle

In mammalian cells, the Golgi apparatus is disassembled at the onset of mitosis and reassembled at the end of mitosis. This disassembly–reassembly is generally believed to be essential for the equal partitioning of Golgi into two daughter cells. For Golgi disassembly, membrane fusion, which is mediated by NSF and p97, needs to be blocked. For the NSF pathway, the tethering of p115-GM130 is disrupted by the mitotic phosphorylation of GM130, resulting in the inhibition of NSF-mediated fusion. In contrast, the p97/p47 pathway does not require p115-GM130 tethering, and its mitotic inhibitory mechanism has been unclear. Now, we have found that p47, which mainly localizes to the nucleus during interphase, is phosphorylated on Serine-140 by Cdc2 at mitosis. The phosphorylated p47 does not bind to Golgi membranes. An in vitro assay shows that this phosphorylation is required for Golgi disassembly. Microinjection of p47(S140A), which is unable to be phosphorylated, allows the cell to keep Golgi stacks during mitosis and has no effect on the equal partitioning of Golgi into two daughter cells, suggesting that Golgi fragmentation-dispersion may not be obligatory for equal partitioning even in mammalian cells.
Strategies to Potentiate Antimicrobial Photoinactivation by Overcoming Resistant Phenotypes †

Conventional antimicrobial strategies have become increasingly ineffective due to the emergence of multidrug resistance among pathogenic microorganisms. The need to overcome these deficiencies has triggered the exploration of alternative treatments and unconventional approaches towards controlling microbial infections. Photodynamic therapy (PDT) was originally established as an anticancer modality and is currently used in the treatment of age‐related macular degeneration. The concept of photodynamic inactivation requires cell exposure to light energy, typically wavelengths in the visible region that causes the excitation of photosensitizer molecules either exogenous or endogenous, which results in the production of reactive oxygen species (ROS). ROS produce cell inactivation and death through modification of intracellular components. The versatile characteristics of PDT prompted its investigation as an anti‐infective discovery platform. Advances in understanding of microbial physiology have shed light on a series of pathways, and phenotypes that serve as putative targets for antimicrobial drug discovery. Investigations of these phenotypic elements in concert with PDT have been reported focused on multidrug efflux systems, biofilms, virulence and pathogenesis determinants. In many instances the results are promising but only preliminary and require further investigation. This review discusses the different antimicrobial PDT strategies and highlights the need for highly informative and comprehensive discovery approaches.
A dynamic mechanical and thermal analysis of unplasticized and plasticized poly(vinyl alcohol)/methylcellulose blends

The miscibility of poly(vinyl alcohol) (PVA)/methylcellulose (MC) blends was investigated over the entire composition range using the dynamic mechanical analyzer (DMA) and the differential scanning calorimeter (DSC). On the basis of the glass transition temperature, determined by DMA, one could conclude that the blends exhibited some miscibility below 80 wt % of MC and a good miscibility above 80 wt % of MC. The highest depressions of the melting and crystallization temperatures of the blends compared to those of PVA, determined via DSC analysis, were observed for MC contents greater than 80 wt %. The miscibility between PVA and MC can be attributed to the hydrogen bonds formed between the two components. The DMA studies showed that water is a good plasticizer for PVA and poly(ethylene glycol) 400 (PEG 400), a good plasticizer for MC. The inclusion of both water and PEG 400 in the blends revealed a synergistic plasticizing effect, which resulted in an increased miscibility between PVA and MC over a greater range of MC compositions (>60 wt %). The elongations of PVA, MC, and their blends were found to increase with the addition of PEG 400, but the tensile strengths to decrease. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 80: 1825–1834, 2001
Hybrid Kinect Depth Map Refinement for Transparent Objects

Depth sensors such as Kinect fail to find the depth of transparent objects which makes 3D reconstruction of such objects a challenge. The refinement algorithms for Kinect depth maps either do not address transparency or they only provide sparse depth on such objects which is inadequate for dense 3D reconstruction. In order to solve this problem, we propose a fully-connected CRF based hybrid refinement algorithm. We incorporate stereo cues from cross-modal stereo between IR and RGB cameras of the Kinect and Kinect's depth map. Our algorithm does not require any additional cameras and still provides dense depth estimations of transparent objects and specular surfaces with high accuracy.
Protein Glutathionylation in the Pathogenesis of Neurodegenerative Diseases

Protein glutathionylation is a redox-mediated posttranslational modification that regulates the function of target proteins by conjugating glutathione with a cysteine thiol group on the target proteins. Protein glutathionylation has several biological functions such as regulation of metabolic pathways, calcium homeostasis, signal transduction, remodeling of cytoskeleton, inflammation, and protein folding. However, the exact role and mechanism of glutathionylation during irreversible oxidative stress has not been completely defined. Irreversible oxidative damage is implicated in a number of neurological disorders. Here, we discuss and highlight the most recent findings and several evidences for the association of glutathionylation with neurodegenerative diseases and the role of glutathionylation of specific proteins in the pathogenesis of neurodegenerative diseases. Understanding the important role of glutathionylation in the pathogenesis of neurodegenerative diseases may provide insights into novel therapeutic interventions.
User frustration in Hit Interfaces: Exploring Past HCI Research for a Better Understanding of Clinicians' Experiences

User frustration research has been one way of looking into clinicians' experience with health information technology use and interaction. In order to understand how clinician frustration with Health Information Technology (HIT) use occurs, there is the need to explore Human-Computer Interaction (HCI) literature that addresses both frustration and HIT use. In the past three decades, HCI frustration research has increased and expanded. Researchers have done a lot of work to understand emotions, end-user frustration and affect. This paper uses a historical literature review approach to review the origins of emotion and frustration research and explore the research question; Does HCI research on frustration provide insights on clinicians' frustration with HIT interfaces? From the literature review HCI research on emotion and frustration provides additional insights that can indeed help explain user frustration in HIT. Different approaches and HCI perspectives also help frame HIT user frustration research as well as inform HIT system design. The paper concludes with a suggested directions on how future design and research may take.
The effect of the microstructure of porous alumina films on the mechanical properties of glass-fiber-reinforced aluminum laminates

The glass-fiber-reinforced aluminum laminates were obtained by anodizing aluminum alloy under anodizing voltage of 10, 20, and 30 V in the 200 g/L H3PO4 electrolyte. Scanning electron microscopy (SEM), short beam, and tensile tests were employed to determine the surface morphology, interlaminar shear strength (ILSS) and tensile strength of laminates, respectively. The results also show that the epoxy penetrates into the pores of the anodic films, and this is the mechanism of adhesion. The ILSS and tensile strength of the anodized specimens (under 20 V) respectively increased by approximately 50 and 15% comparing with those of the non-anodized specimens. This increase of mechanical properties results from the porous surface of aluminum providing greater mechanical interlocking to epoxy. The ILSS and tensile strengths of the anodized specimens increased with the increase of anodizing voltage from 10 to 20 V; however, it decreased when the voltage further increased to 30 V. It is considered that the microstructure evolution of the porous films has a significant effect on the mechanical properties of the laminates.
In vivo and Postmortem Clinicoanatomical Correlations in Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17

Background: Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) is associated with mutations in the Microtubule-Associated Protein Tau(MAPT) gene or the Progranulin(PGRN) gene. MAPT mutations lead to widespread deposition of hyperphosphorylated tau protein (FTDP-17T). PGRN mutations are associated with ubiquitin- and TDP-43-positive inclusions in the frontotemporal cortex, striatum and hippocampus (FTDP-17U). Despite the differences, FTDP-17T and FTDP-17U share a largely overlapping clinical phenotype. Objective: To determine whether neuroimaging studies may allow an in vivo early differentiation between FTDP-17T and FTDP-17U. Methods: We studied 25 individuals affected with FTDP-17T associated with either the exon 10+3 (24 subjects) or the G335S (1 subject) MAPT mutation, as well as 3 FTDP-17U individuals, who were carriers of the A9D, IVS6-2A>G or R493X PGRN mutation. Neuroimaging studies, obtained along the course of the disease, were compared to the neuropathologic findings. Results: FTDP-17T cases were associated with symmetric frontotemporal atrophy. Behavioral changes constituted the predominant clinical presentation. Conversely, an asymmetric degenerative process was seen in all 3 PGRN cases, who presented with either corticobasal syndrome (A9D) or frontotemporal dementia and language deterioration (IVS6-2A>G and R493X). Conclusion: Neuroimaging data, in the early disease stage of FTDP-17, may offer the possibility of an early differentiation of FTDP-17T and FTDP-17U phenotypes, independent of the genetic analysis.
A Modified Artificial Bee Colony for Solving the Container Loading Problem

paper presents a modified artificial bee colony for solving the container loading problem because the cost can be reduced by increasing the space utilization ratio. This problem is solved in a two phased a Modified Artificial Bee Colony Optimization (MABCO) and a Wall-building approach. In the first phase, MABCO with its probabilistic decision rule is used to construct a sequence of boxes. The boxes are then arranged into a container with the Wall-building heuristic in the second phase. The nectar information feedback of MABCO using neighborhood updating rule helped to improve the solutions. Computational experiments were conducted on benchmark data set and the results obtained from the proposed approach are shown to be comparable with other methods from the literatures. General Terms Artificial Bee Colony, Container Loading Problem Keywordsproblem; Container loading; Bee colony; Wall- building; Meta-heuristic
Activation of the Transducers of Unfolded Protein Response in Plants

Maintenance of homeostasis of the endoplasmic reticulum (ER) ensures the balance between loading of nascent proteins and their secretion. Certain developmental conditions or environmental stressors affect protein folding causing ER stress. The resultant ER stress is mitigated by upregulating a set of stress-responsive genes in the nucleus modulating the mechanism of the unfolded protein response (UPR). In plants, the UPR is mediated by two major pathways; by the proteolytic processing of bZIP17/28 and by the IRE1-mediated splicing of bZIP60 mRNA. Recent studies have shown the involvement of plant-specific NAC transcription factors in UPR regulation. The molecular mechanisms activating plant-UPR transducers are only recently being unveiled. This review focuses on important structural features involved in the activation of the UPR transducers like bZIP17/28/60, IRE1, BAG7, and NAC017/062/089/103. Also, we discuss the activation of the UPR pathways, including BAG7-bZIP28 and IRE1-bZIP60, in detail, together with the NAC-TFs, which adds a new paradigm to the plant UPR.
Metal Carbides for Biomass Valorization

Transition metal carbides have been utilized as an alternative catalyst to expensive noble metals for the conversion of biomass. Tungsten and molybdenum carbides have been shown to be effective catalysts for hydrogenation, hydrodeoxygenation and isomerization reactions. The satisfactory activities of these metal carbides and their low costs, compared with noble metals, make them appealing alternatives and worthy of further investigation. In this review, we succinctly describe common synthesis techniques, including temperature-programmed reaction and carbothermal hydrogen reduction, utilized to prepare metal carbides used for biomass transformation. Attention will be focused, successively, on the application of transition metal carbide catalysts in the transformation of first-generation (oils) and second-generation (lignocellulose) biomass to biofuels and fine chemicals.
A FIRST LOOK AT CREATING MOCK CATALOGS WITH MACHINE LEARNING TECHNIQUES

We investigate machine learning (ML) techniques for predicting the number of galaxies (Ngal) that occupy a halo, given the halo's properties. These types of mappings are crucial for constructing the mock galaxy catalogs necessary for analyses of large-scale structure. The ML techniques proposed here distinguish themselves from traditional halo occupation distribution (HOD) modeling as they do not assume a prescribed relationship between halo properties and Ngal. In addition, our ML approaches are only dependent on parent halo properties (like HOD methods), which are advantageous over subhalo-based approaches as identifying subhalos correctly is difficult. We test two algorithms: support vector machines (SVM) and k-nearest-neighbor (kNN) regression. We take galaxies and halos from the Millennium simulation and predict Ngal by training our algorithms on the following six halo properties: number of particles, M200, σv, vmax, half-mass radius, and spin. For Millennium, our predicted Ngal values have a mean-squared error (MSE) of ∼0.16 for both SVM and kNN. Our predictions match the overall distribution of halos reasonably well and the galaxy correlation function at large scales to ∼5%–10%. In addition, we demonstrate a feature selection algorithm to isolate the halo parameters that are most predictive, a useful technique for understanding the mapping between halo properties and Ngal. Lastly, we investigate these ML-based approaches in making mock catalogs for different galaxy subpopulations (e.g., blue, red, high Mstar, low Mstar). Given its non-parametric nature as well as its powerful predictive and feature selection capabilities, ML offers an interesting alternative for creating mock catalogs.
Energy Flow and Thermal Comfort in Buildings

Description: Heating and cooling terminals can be classified in two main categories: convective terminals (e.g air conditioning, active chilled beam, fan coil) and radiant terminals. The two terminals have different modes of heat transfer: the first one is mainly based on convection, whereas the second one is based on both radiation and convection. This thesis focuses on characterizing the heat transfer from the terminal towards the space and on the parameters influencing the effectiveness of terminals. Therefore the comfort conditions and energy consumption of four types of terminals (active chilled beam, radiant floor, wall and ceiling) have been compared for a typical office room, both numerically and experimentally.
Dysbiosis of urinary microbiota is positively correlated with Type 2 diabetes mellitus

Type 2 diabetes mellitus (T2DM) may be associated with altered urinary microbiota in female patients. We investigated alterations of urinary microbiota in Chinese female T2DM patients, and explored the associations between urinary microbiota and a patient’s fasting blood glucose (FBG), urine glucose (UGLU), age, menstrual status, and body mass index (BMI). Midstream urine was collected from 70 female T2DM patients and 70 healthy females. Microbial diversity and composition were analyzed using the Illumina MiSeq sequencing platform by targeting the hypervariable V3-V4 regions of the 16S rRNA gene. We found that bacterial diversity was decreased in T2DM patients. Increased Actinobacteria phylum was positively correlated with FBG, UGLU, and BMI; Lactobacillus abundance decreased with age and menopause; and increased Lactobacillus correlated positively with FBG and UGLU. Decreased Akkermansia muciniphila was associated with FBG and UGLU. Escherichia coli abundance did not differ between the two cohorts. Carbohydrate and amino acid metabolism was reduced in T2DM patients, which were associated with bacterial richness indices such as Chao1 and ACE. Detailed microbiota analysis of well-characterized T2DM patients and healthy controls indicate that Chinese T2DM female patients exhibit dysbiosis of urinary microbiota.
Toward Extending the Compromise Effect to Complex Buying Contexts

Kivetz, Netzer, and Srinivasan (2004) make an important contribution to the theory of choice models by demonstrating through a rigorous analysis of four alternative models that the compromise effect systematically affects choice in a wide range of conditions. The value and impact of their work can be enhanced by extensions that examine key underlying institutional variables that may shape the nature and scope of compromise effects. The authors provide a set of issues that further research can effectively pursue in the context of institutional buying processes and the purchase of complex solutions rather than individual products.