Miracle-dz/UniFAR-FTUs huggingface dataset:
Laryngeal Mask Airway Supreme in Children: A Retrospective Audit

Background: The laryngeal mask airway (LMA) Supreme (LMAS) is a sophisticated, second-generation supraglottic airway device, with an improved seal, and gastric access. It is a capable device for use in more complex procedures and in younger children. No study has been able to analyze a large pediatric sample of patients to assess how the LMAS is being utilized. In this retrospective audit, we evaluated the use of the LMAS in routine clinical practice. In addition to this, utilization of LMAS performance test was evaluated.Methods: A retrospective audit was performed of a major tertiary children's hospital's electronic medical record database to identify all children in whom the LMAS was utilized for airway management over a two-year period. In addition to demographic data, we collected the following LMAS data: size of the LMAS, the number of insertion attempts, volume of air injected into the cuff, the cuff pressure, and the oropharyngeal leak pressure. We also recorded the performance of tests for proper position and function, the mode of lung ventilation, the use of muscle relaxants and use of any alternative airway devices.Results: The LMAS was used in 418 children accounting for only 4% of all LMA usage and only 0.6% of all usage for general anesthesia. The first-attempt placement success rate was 96.4% (382/396). Five of 418 (1.2%) insertions were reported as failures. Mechanical ventilation was used in only 26% of cases with a vast majority (74%) breathing spontaneously. Cuff pressure was measured in 74/418 (18%) of cases. Oropharyngeal leak pressures were measured in 90/418 (21.5%) cases. Maneuvers performed to verify correct placement and performance of the LMAS were rarely performed. Use of the LMAS for invasive procedures occurred in only 5 cases (1.2%). Conclusions: This study shows the LMAS to be highly successful in the hands of various cadres of anesthesia providers at a major tertiary hospital and performs reliably well. Our data reveals many areas of potential improvement for use of the LMAS in the pediatric population, as a device capable for usage in more invasive surgical procedures, younger patients, and mechanical ventilation. Citation: Nobuyuki-Hai Tran, Patrick N. Olomu, Ashley Bocanegra, Asif Khan, John Cheyney, Alexandra Handy, et al. Laryngeal mask airway Supreme in children: a retrospective audit. J Anesth Perioper Med 2016; 3: 241-6. doi: 10.24015/JAPM.2016. 0033This is an open-access article, published by Evidence Based Communications (EBC). This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium or format for any lawful purpose. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Esophageal provocation tests: Are they useful to improve diagnostic yield of high resolution manometry?

High resolution manometry (HRM) is the gold standard to diagnose esophageal motility disorders but has some limitations. The inclusion of provocative tests might enhance the diagnostic yield of HRM. These tests are easy to perform and to add to the regular manometry protocol. Multiple rapid swallows (MRS; 5 2‐mL swallows) is useful to assess the contractile reserve and deglutitive inhibition. The optimal number of MRS to perform might be 3 as suggested by Mauro et al. in this issue of Neurogastroenterology & Motility. The absence of contractile reserve might be associated with gastro‐esophageal reflux disease and with an increased risk of post fundoplication dysphagia. Single viscous and solid swallows might enhance the detection of esophageal motility disorders but are not significantly associated with symptom occurrence. Test meal has the advantage to represent a real‐life scenario and is promising to depict significant motility findings responsible for esophageal symptoms. Post‐prandial recording might also be of interest to diagnose rumination and belching disorders. The best indication of rapid drink challenge test (free drinking of 200 mL) is currently the diagnosis of esophago‐gastric junction obstruction. Finally, abdominal compression might be an option to evaluate response of esophageal peristalsis in a context of outflow resistance as proposed by Brink et al. in this issue. These provocative maneuvers appear to provide a complementary role in the evaluation of esophageal motility but require prospective studies to determine the validity of the findings and whether they will lead to changes in clinical practice.
The Association between Sleep and Theory of Mind in School Aged Children with ADHD

Theory of Mind (ToM) is defined as the ability to infer a range of internal mental states of others, including beliefs, intentions, desires, and emotions. These abilities are associated with children’s ability to socialize effectively with peers. ToM impairments are associated with peer rejection and psychiatric disorders such as Attention-Deficit/Hyperactivity Disorder (ADHD). Previous studies have found poor sleep negatively impacts executive functioning (EF) and emotional information processing, which are essential for the effective use of ToM. Youth with ADHD have EF deficits and sleep problems. However, the relationship between sleep, executive functioning, and ToM in children with ADHD has not been studied. In this review, we propose that the poor social and interpersonal skills characterizing individuals with ADHD could be explained by the impact of poor sleep on the emotional and cognitive mechanisms underlying ToM.
Triboelectric Power Generation from Paper Vibration Induced by Sonic Waves

Abstract Paper is a material with a high Young’s modulus that vibrates sensitively due to environmental noise, voice, and sound. This study aims to create a triboelectric power generator to convert this sonic vibration energy into electrical energy to power microelectronics embedded on paper. A sonic wave has two wave modes, transverse and longitudinal, that propagate in paper; therefore, two types of triboelectric power generators were designed for trial simulation as the first step. A triboelectrically charged polytetrafluoroethylene sheet and a back electrode were attached to a paperboard. Another paperboard with a counter electrode attached was vibrated in the out-of-plane direction corresponding to transverse waves such that it would repeatedly move toward and away from the other paperboard. The generated power between the two electrodes reached 11.8 µW at 2 MΩ load. When comb-shaped electrodes were applied, manual strokes in the in-plane direction, corresponding to a longitudinal wave, induced voltage up to 8.2 V. The result suggested that sonic waves could be an electric power source for microelectronics in the future.
Pseudomonas aeruginosa uses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix

Pseudomonas aeruginosa, the principal pathogen of cystic fibrosis patients, forms antibiotic‐resistant biofilms promoting chronic colonization of the airways. The extracellular (EPS) matrix is a crucial component of biofilms that provides the community multiple benefits. Recent work suggests that the secondary messenger, cyclic‐di‐GMP, promotes biofilm formation. An analysis of factors specifically expressed in P. aeruginosa under conditions of elevated c‐di‐GMP, revealed functions involved in the production and maintenance of the biofilm extracellular matrix. We have characterized one of these components, encoded by the PA4625 gene, as a putative adhesin and designated it cdrA. CdrA shares structural similarities to extracellular adhesins that belong to two‐partner secretion systems. The cdrA gene is in a two gene operon that also encodes a putative outer membrane transporter, CdrB. The cdrA gene encodes a 220 KDa protein that is predicted to be rod‐shaped protein harbouring a β‐helix structural motif. Western analysis indicates that the CdrA is produced as a 220 kDa proprotein and processed to 150 kDa before secretion into the extracellular medium. We demonstrated that cdrAB expression is minimal in liquid culture, but is elevated in biofilm cultures. CdrAB expression was found to promote biofilm formation and auto‐aggregation in liquid culture. Aggregation mediated by CdrA is dependent on the Psl polysaccharide and can be disrupted by adding mannose, a key structural component of Psl. Immunoprecipitation of Psl present in culture supernatants resulted in co‐immunoprecipitation of CdrA, providing additional evidence that CdrA directly binds to Psl. A mutation in cdrA caused a decrease in biofilm biomass and resulted in the formation of biofilms exhibiting decreased structural integrity. Psl‐specific lectin staining suggests that CdrA either cross‐links Psl polysaccharide polymers and/or tethers Psl to the cells, resulting in increased biofilm structural stability. Thus, this study identifies a key protein structural component of the P. aeruginosa EPS matrix.
Local CXCR4 Upregulation in the Injured Arterial Wall Contributes to Intimal Hyperplasia

CXCR4 is a stem/progenitor cell surface receptor specific for the cytokine stromal cell‐derived factor‐1 (SDF‐1α). There is evidence that bone marrow‐derived CXCR4‐expressing cells contribute to intimal hyperplasia (IH) by homing to the arterial subintima which is enriched with SDF‐1α. We have previously found that transforming growth factor‐β (TGFβ) and its signaling protein Smad3 are both upregulated following arterial injury and that TGFβ/Smad3 enhances the expression of CXCR4 in vascular smooth muscle cells (SMCs). It remains unknown, however, whether locally induced CXCR4 expression in SM22 expressing vascular SMCs plays a role in neointima formation. Here, we investigated whether elevated TGFβ/Smad3 signaling leads to the induction of CXCR4 expression locally in the injured arterial wall, thereby contributing to IH. We found prominent CXCR4 upregulation (mRNA, 60‐fold; protein, 4‐fold) in TGFβ‐treated, Smad3‐expressing SMCs. Chromatin immunoprecipitation assays revealed a specific association of the transcription factor Smad3 with the CXCR4 promoter. TGFβ/Smad3 treatment also markedly enhanced SDF‐1α‐induced ERK1/2 phosphorylation as well as SMC migration in a CXCR4‐dependent manner. Adenoviral expression of Smad3 in balloon‐injured rat carotid arteries increased local CXCR4 levels and enhanced IH, whereas SMC‐specific depletion of CXCR4 in the wire‐injured mouse femoral arterial wall produced a 60% reduction in IH. Our results provide the first evidence that upregulation of TGFβ/Smad3 in injured arteries induces local SMC CXCR4 expression and cell migration, and consequently IH. The Smad3/CXCR4 pathway may provide a potential target for therapeutic interventions to prevent restenosis. Stem Cells 2016;34:2744–2757
Towards a study opportunities recommender system in ontological principles-based on semantic web environment

A professional career selection is a complicated process for university student candidates and often little technical tolls are available for who aim to enter to the superior education system, since it is necessary to consider the incidence of a multiplicity of variables to obtain a "satisfactory answer" that comes near to the idea that they have preconceived. These variables build up a complex relations map that requires the formulation of an exhaustive and rigorous conceptual scheme. In this research a domain ontological model is presented as support to the student's decision making for opportunities of University studies level of the Venezuelan education system. For the declaration of the domain ontological model developed, the information provided by two organisms (OPSU & CNU) is used. Both are responsible to design the policies and strategies for the superior education in Venezuela. The ontology is designed and created using Methontology approach, since this methodology offers the possibility of improving the progressive creation or captures and knowledge articulation, its elements and relations. In order to represent the ontology Protege 3.1. 1 tool is used, based on the ontological language for the Web: OWL (Web Ontology Language) and; finally, to accede and to visualize the ontology, an application based on the Semantic Web is developed. In the field of the computation, computer science and systems, the concept of profiles or users models has many meanings and connotations, its first and greater diffusion arise with the development and use of on-line increasing systems; however, they have gain great preponderance recently, not only to refer and/or to respond to the passive user who approaches "the system", but for the possibility of taking care of a user stimulated and attracted by "the system". In that sense, the possibility of this "personalized attention" and/or recommendations from "the system" will be obviously conditioned by the user context. Centered on the possibility of giving that "customized attention" from which they must select an option between many, it is tried in the future to construct a meta-ontology that integrates the domain ontology with a user profile ontology, thus aiming towards to a Semantic Recommendation System under Multiagent approach in the future, that could be useful to support students decision making process for career selection over different study opportunities in Higher Education level in Venezuela.
Exploring the "Middle Earth" of Network Spectra via a Gaussian Matrix Function

We study a Gaussian matrix function of the adjacency matrix of artificial and real-world networks. We motivate the use of this function on the basis of a dynamical process modeled by the time-dependent Schrödinger equation with a squared Hamiltonian. In particular, we study the Gaussian Estrada index-an index characterizing the importance of eigenvalues close to zero. This index accounts for the information contained in the eigenvalues close to zero in the spectra of networks. Such a method is a generalization of the so-called "Folded Spectrum Method" used in quantum molecular sciences. Here, we obtain bounds for this index in simple graphs, proving that it reaches its maximum for star graphs followed by complete bipartite graphs. We also obtain formulas for the Estrada Gaussian index of Erdős-Rényi random graphs and for the Barabási-Albert graphs. We also show that in real-world networks, this index is related to the existence of important structural patterns, such as complete bipartite subgraphs (bicliques). Such bicliques appear naturally in many real-world networks as a consequence of the evolutionary processes giving rise to them. In general, the Gaussian matrix function of the adjacency matrix of networks characterizes important structural information not described in previously used matrix functions of graphs.
Reconsidering Values in Biomedical Research

In 2016, almost half of the top 100 most discussed articles were in medical and health sciences, according to Altmetric. Seen from a financial perspective, annually in the USA nearly $32.3 billion are dedicated to biomedical research by the NIH alone. Recent achievements in this field have led to some impressive progress in human health and medicine. However, despite seemingly unlimited access to information and availability of advanced research technology, non-communicable chronic diseases remain a major cause of morbidity and mortality, accounting for 70% of total global deaths in 2015, based onWHO reports. “The medium is the message,” according to Marshall McLuhan, who believed that the medium to which a message attaches itself influences the message itself. Nicholas Carr, author of “The Shallows” showed that the internet, as the dominant medium in the new age, changes reading behavior and ways of thinking. In addition, some neurological studies using Magnetic Resonance Imaging reveal that online searching activates different parts of the brain and rewires the neural circuits that control memory and decision making, in comparison with the traditional paper-based media. Scientists and postgraduate students rely heavily on online data banks to ensure that their information is up to date, and to generate new ideas. Although researchers carefully select keywords to achieve the best results from online searches, their results are likely to be filtered using algorithms that can, perhaps inadvertently, be biased. It has been shown that 44% of users click on the first link provided in the search output, and even the second result gets only 28% attention. H-index, citations and journal impact factor are metrics of the digital age that are widely used by search engines or their users for ranking search results. As a result, online searching actively pushes researchers toward particular papers with high citations in high impact factor journals as a source of valid information. The search results have a direct impact on both the question being asked and the hypothesis being tested. “Group Think” sets in as the reader is persuaded to follow the masters presented in top hits. The technology that was designed to provide egalitarian access to everythingmay give us a
Multicore Large-Scale Integration Lifetime Extension by Negative Bias Temperature Instability Recovery-Based Self-Healing

We propose a multicore large-scale integration (LSI) lifetime extension method, which is based on negative bias temperature instability (NBTI) recovery-based self-healing and circuit parallelization. NBTI recovery is characterized by the recently proposed NBTI sensor with 400 ns measurement delay that measures the off-leak current of p-channel metal–oxide–semiconductor (PMOS) transistors. The circuit is fabricated in a commercial 65 nm complementary MOS (CMOS) technology. It is found that the recoverable component of the LSI performance characterized by the off-leak current remains almost constant after repeatedly adding NBTI stress. The NBTI stress corresponds to circuit operation for several years at room temperature and a nominal operating voltage. It is also found that the amount of NBTI recovery can be tuned by the relaxation time in a real application, and it follows log t from 400 ns to 3000 s. It is shown that for multicore LSI, by recovering one of the n + 1 cores, the n-core LSI system does not stop and the lifetime can be extended by NBTI recovery. For the first time, transforming silicon area into LSI reliability is shown to be a promising and realistic concept for the ever-shrinking CMOS technology.
Transcriptional Activation of Apolipoprotein CIII Expression by Glucose May Contribute to Diabetic Dyslipidemia

Objective—Hypertriglyceridemia and fatty liver are common in patients with type 2 diabetes, but the factors connecting alterations in glucose metabolism with plasma and liver lipid metabolism remain unclear. Apolipoprotein CIII (apoCIII), a regulator of hepatic and plasma triglyceride metabolism, is elevated in type 2 diabetes. In this study, we analyzed whether apoCIII is affected by altered glucose metabolism. Methods and Results—Liver-specific insulin receptor–deficient mice display lower hepatic apoCIII mRNA levels than controls, suggesting that factors other than insulin regulate apoCIII in vivo. Glucose induces apoCIII transcription in primary rat hepatocytes and immortalized human hepatocytes via a mechanism involving the transcription factors carbohydrate response element–binding protein and hepatocyte nuclear factor-4&agr;. ApoCIII induction by glucose is blunted by treatment with agonists of farnesoid X receptor and peroxisome proliferator-activated receptor-&agr; but not liver X receptor, ie, nuclear receptors controlling triglyceride metabolism. Moreover, in obese humans, plasma apoCIII protein correlates more closely with plasma fasting glucose and glucose excursion after oral glucose load than with insulin. Conclusion—Glucose induces apoCIII transcription, which may represent a mechanism linking hyperglycemia, hypertriglyceridemia, and cardiovascular disease in type 2 diabetes.
Progress of Study on Passive Targeting of Drug Delivery System

Recently,the passive targeting system is broadly investigated at home and abroad.In this review, the passive targeting systems of mechanism,significances and a variety of targeted carriers are introduced.The advanta- ges and disadvantages of liposomes,nanocapsules,emulsions and microbubbles are analyzed.Its developing direction and future are put forward.
Nonnuclear Hyper/Ultraluminous X-Ray Sources in the Starbursting Cartwheel Ring Galaxy

We report the Chandra/ACIS-S detection of more than 20 ultraluminous X-ray sources (ULXs; L0.5-10 keV ≳ 3 × 1039 ergs s-1) in the Cartwheel collisional ring galaxy system, of which over a dozen are located in the outer active star-forming ring. A remarkable hyperluminous X-ray source (HLX; L0.5-10 keV ≳ 1041 ergs s-1 assuming isotropic radiation), which dominates the X-ray emission from the Cartwheel ring, is located in the same segment of the ring as most ULXs. These powerful H/ULXs appear to be coincident with giant H II region complexes, young star clusters, and radio and mid-infrared hot spots: all strong indicators of recent massive star formation. The X-ray spectra show that H/ULXs have similar properties as those of the most luminous ULXs found in the nearest starbursts and galaxy mergers such as the Antennae galaxies and M82. The close association between the X-ray sources and the starbursting ring strongly suggests that the H/ULXs are intimately associated with the production and rapid evolution of short-lived massive stars. The observations represent the most extreme X-ray luminosities discovered to date associated with star-forming regions—rivaling the X-ray luminosities usually associated with active galactic nuclei.
Four eyes are better than two: On the impact of code reviews on software quality

Code review is advocated as one of the best practices to improve software quality and reduce the likelihood of introducing defects during code change activities. Recent research has shown how code components having a high review coverage (i.e., a high proportion of reviewed changes) tend to be less involved in post-release fixing activities. Yet the relationship between code review and bug introduction or the overall software quality is still largely unexplored.
Downregulated protein expression of transcriptional activator ELK-1 in atrial myocardium of chronic AF patients.

BACKGROUND The structural alterations in atrial myocytes appear to be an adaptive response of dedifferentiation during chronic atrial fibrillation (AF). Transcriptional activator ELK-1, one of the members of ETS family, has been shown to play an important role in regulating cell differentiation, It is reasonable to presume that ELK-1 participate in the molecular and structural remodeling by which AF is sustained. To prove this hypothesis, the expression of ELK-1 protein in chronically fibrillating atria compared to that in normal rhythmic atria was detected. METHODS Right atrial myocardium were obtained from twenty-four patients undergoing valve replacement surgery, twelve patients were in chronic AF (>6 months), whereas the others were in sinus rhythm (SR). The protein expression level of ELK-1 was quantified by Western blot analysis, and the cellular localization and expression pattern of ELK-1 was examined by immunohistochemical staining and indirect immunofluorescence. RESULTS Western blot analysis showed that the protein expression of ELK-1 was significantly reduced in the atrial tissue of chronic AF patients compared to that in the controls. Immunohistochemistry showed that ELK-1 immunostaining occurred in both cytosolic and nuclear compartments of atrial myocardium. Indirect immunofluorescence showed that the nuclei of normal rhythmic atrial cells were densely labeled, whereas the nuclei in chronically fibrillating atrial cells were very faintly labeled. CONCLUSIONS Our results suggest that the downregulated expression of transcriptional activator ELK-1 may play an important role in the pathogenesis of AF.