Miracle-dz/UniFAR-FTUs huggingface dataset:
Fermented Perilla frutescens Ameliorates Depression-like Behavior in Sleep-Deprivation-Induced Stress Model

Excessive stress plays a critical role in the pathogenesis of mood disorders such as depression. Fermented natural products have recently attracted attention because of their health benefits. We evaluated the antidepressant-like efficacy of fermented Perilla frutescens (FPF), and its underlying mechanisms, in sleep deprivation (SD)-induced stress mice. SD-stressed mice revealed a remarkable increase in the immobility time in both forced swimming test and tail suspension test; this increase was ameliorated by treatment with FPF at doses of 100 and 150 mg/kg. FPF treatment also reduced the level of stress hormones such as corticosterone and adrenocorticotropic hormone. Additionally, FPF increased the levels of serotonin and dopamine which were significantly decreased in the brain tissues of SD-stressed mice. The increased expression of proinflammatory cytokines, such as TNF-α and IL1β, and the decreased expression of brain-derived neurotrophic factor (BDNF) in the stressed mice were significantly reversed by FPF treatment. Furthermore, FPF also increased phosphorylation of tropomyosin receptor kinase B (TrkB), extracellular regulated protein kinase (ERK), and cAMP response element binding protein (CREB). Among the six components isolated from FPF, protocatechuic acid and luteolin-7-O-glucuronide exhibited significant antidepressant-like effects, suggesting that they are major active components. These findings suggest that FPF has therapeutic potential for SD-induced stress, by correcting dysfunction of hypothalamic-pituitary-adrenal axis and modulating the BDNF/TrkB/ERK/CREB signaling pathway.
ANALYSE THE CHALLENGES FACED BY GIG WORKERS DURING THE COVID PANDEMIC IN INDIA - CASE STUDY OF OLA DRIVERS

The uncertain and unexpected outbreak of the COVID-19 pandemic affected the economic status of many businesses worldwide. The paper aims to critically examine the degree of devastation experienced by the Indian gig workers due to the pandemic restriction. The uncertainty and illegal practices of the gig employers and the way the gig workers in India get exploited from time to time due to their unemployment status is critically analysed in this paper. The paper compactly discussed the challenges experienced by the Indian gig workers, especially the Ola and other cab drivers during the very beginning of the lockdown. The way the cab drivers and the entire Indian cab industry have already suffered is included in the report. The present status of the gig workers involved in Ola is also analysed in this paper. The socio-economic issues caused by the COVID-19 pandemic that affected the survival of the cab drivers in India is illustrated in this paper. The paper also identified the strategies implemented by abroad countries to deal with the uncertain condition of the Indian gig workers. The measures taken by the Indian government to uplift the condition of the Ola drivers is also included in the paper.
Design, Synthesis and Evaluation of New Multifunctional Benzothiazoles as Photoprotective, Antioxidant and Antiproliferative Agents

A current trend of research in the health field is toward the discovery of multifunctional compounds, capable of interacting with multiple biological targets, thus simplifying multidrug therapies and improving patient compliance. The aim of this work was to synthesize new multifunctional chemical entities bearing a benzothiazole nucleus, a structure that has attracted increasing interest for the great variety of biological actions that it can perform, and already used as a scaffold in several multifunctional drugs. Compounds are reported, divided into two distinct series, synthetized and tested in vitro for the antioxidant, and include UV-filtering and antitumor activities. DPPH and FRAP tests were chosen to outline an antioxidant activity profile against different radical species. The UV-filtering activity was investigated, pre- and post-irradiation, through evaluation of a O/W sunscreen standard formulation containing 3% of the synthetic compounds. The antitumor activity was investigated both on human melanoma cells (Colo-38) and on immortalized human keratinocytes as a control (HaCat). A good antiproliferative profile in terms of IC50 was chosen as a mandatory condition to further investigate apoptosis induction as a possible cytotoxicity mechanism through the Annexin V test. Compound BZTcin4 was endowed with excellent activity and a selectivity profile towards Colo-38, supported by a good antioxidant capacity and an excellent broad-spectrum photoprotective profile.
A Case of Congenital Pulmonary Vein Stenosis with Secondary Post-Capillary Pulmonary Hypertension and Left Sided Congestive Heart Failure in a Cat

Simple Summary Left-sided congestive heart failure and post-capillary pulmonary hypertension are commonly associated with left atrial enlargement. An instrumental step in diagnosing left-sided congestive heart in cats is confirming the presence of left atrial enlargement. However, in selected cases, left-sided congestive heart and post-capillary pulmonary hypertension may be present while the left atrium is not enlarged. This case report presents a 5-month-old Maine Coon cat with congenital pulmonary vein stenosis resulting in severe left-sided congestive heart and post-capillary pulmonary hypertension without left atrial enlargement. Abstract A five-month-old, 3.8 kg intact male Maine coon cat presented for dyspnea characterized by increased respiratory effort in addition to open-mouth breathing. Thoracic radiographs showed pectus excavatum, enlarged cardiac silhouette, and generalized interstitial patterns. Echocardiography revealed normal left atrial (LA) and left ventricular dimensions. A large tubular structure, suspected to be a distended pulmonary vein (PV), was identified as draining into the LA. Severe eccentric and concentric right ventricular hypertrophy and paradoxical septal motion were noted. Based on Doppler echocardiography, both pulmonary venous and pulmonary artery pressure was severely elevated. Clinical, radiographic, and echocardiographic abnormalities were hypothesized to result from pulmonary vein stenosis (PVS), causing severely elevated pulmonary venous pressures and resulting in clinical signs of left-sided congestive heart failure (L-CHF) and severe post-capillary pulmonary hypertension (Pc-PH). The prognosis for good quality of life was assessed as poor, and the owner elected euthanasia. Necropsy confirmed the presence of PVS with severe dilation of the PVs draining all but the left cranial lung lobe. All lung lobes except the left cranial lobe had increased tissue density and a mottled cut surface. This case report shows that, in rare cases, both L-CHF and Pc-PH may be present without LA enlargement. To the authors’ knowledge, this is the first report on PVS in veterinary medicine.
Measurement accuracy analysis of photocarrier radiometric determination of electronic transport parameters of silicon wafers

Simulations are performed to investigate the accuracy of the simultaneous determination of the electronic transport properties (the carrier lifetime, the carrier diffusion coefficient, and the front and rear surface recombination velocities) of silicon wafers by means of the photocarrier radiometry (PCR) technique through fitting frequency-scan data to a rigorous model via a multi-parameter fitting process. The uncertainties of the fitted parameter values are analyzed by calculating the dependence of the square variance including both amplitude and phase variances on the electronic transport properties. Simulation results show that the ability of the PCR to accurately determine carrier lifetimes gradually decreases for lifetimes longer than roughly 100 microseconds. In case the carrier diffusion coefficient is previously known, the carrier lifetime and front surface recombination velocity can be determined with uncertainties approximately +/-20% or less. Experiments with an ion-implanted silicon wafer were performed and the carrier lifetime and front surface recombination velocity were determined with estimated uncertainties approximately +/-30% and +/-15%, respectively. (C) 2005 American Institute of Physics.
Supermagnetic Human Serum Albumin (HSA) Nanoparticles and PLGA-Based Doxorubicin Nanoformulation: A Duet for Selective Nanotherapy

Predicting the ability of nanoparticles (NP) to access the tumor is key to the success of chemotherapy using nanotherapeutics. In the present study, the ability of the dual NP-based theranostic system to accumulate in the tumor was evaluated in vivo using intravital microscopy (IVM) and MRI. The system consisted of model therapeutic doxorubicin-loaded poly(lactide-co-glycolide) NP (Dox-PLGA NP) and novel hybrid Ce3/4+-doped maghemite NP encapsulated within the HSA matrix (hMNP) as a supermagnetic MRI contrasting agent. Both NP types had similar sizes of ~100 nm and negative surface potentials. The level of the hMNP and PLGA NP co-distribution in the same regions of interest (ROI, ~2500 µm2) was assessed by IVM in mice bearing the 4T1-mScarlet murine mammary carcinoma at different intervals between the NP injections. In all cases, both NP types penetrated into the same tumoral/peritumoral regions by neutrophil-assisted extravasation through vascular micro- and macroleakages. The maximum tumor contrasting in MRI scans was obtained 5 h after hMNP injection/1 h after PLGA NP injection; the co-distribution level at this time reached 78%. Together with high contrasting properties of the hMNP, these data indicate that the hMNP and PLGA NPs are suitable theranostic companions. Thus, analysis of the co-distribution level appears to be a useful tool for evaluation of the dual nanoparticle theranostics, whereas assessment of the leakage areas helps to reveal the tumors potentially responsive to nanotherapeutics.
Thermal infrared and nonthermal radio: remarkable correlation in disks of galaxies

A tight, linear correlation is established between the far-infrared flux measured by IRAS and the nonthermal radio flux density (at 1.4 GHz) from disks of spiral galaxies. This correlation defines a ratio of infrared to radio fluxes that is characteristic of star formation activity. Galaxies with nuclear starbursts seem to follow the correlation. If the far-infrared is reradiated luminosity from young massive stars, then the supernova remnants alone account for less than 10 percent of the radio emission. These results indicate a close coupling between dust heating and cosmic-ray generation and confinement in a wide range of conditions. 32 references.
Electronic and Magnetic Properties of K2Mn3S4

Many opto-electronic and energy efficient devices depend on semiconductors’ direct as well as indirect band gap. Using spin-polarized density functional theory approach, we calculate the electronic structure and magnetic properties of K2Mn3S4. We found that this system has a ferrimagnetic ground state with a saturated magnetic moment of 10μB per unit cell. This was mostly caused by the antiferromagnetic interaction between the Mn (I) and Mn (II) atoms, with individual magnetic moment of 4.2 μB and 4.1 μB, respectively. More significantly, from the density of states and band structure calculations, K2Mn3S4 is noted as a semiconductor with an indirect band gap of 1.1 eV between the top of the valence band of spin up channel and bottom of the conduction bands of spin down channel, indicating the material as a promising candidate for photovoltaic and opto-electronic devices.
Azithromycin Mitigates Cisplatin-Induced Lung Oxidative Stress, Inflammation and Necroptosis by Upregulating SIRT1, PPARγ, and Nrf2/HO-1 Signaling

Acute lung injury (ALI) is one of the adverse effects of the antineoplastic agent cisplatin (CIS). Oxidative stress, inflammation, and necroptosis are linked to the emergence of lung injury in various disorders. This study evaluated the effect of the macrolide antibiotic azithromycin (AZM) on oxidative stress, inflammatory response, and necroptosis in the lungs of CIS-administered rats, pinpointing the involvement of PPARγ, SIRT1, and Nrf2/HO-1 signaling. The rats received AZM for 10 days and a single dose of CIS on the 7th day. CIS provoked bronchial and alveolar injury along with increased levels of ROS, MDA, NO, MPO, NF-κB p65, TNF-α, and IL-1β, and decreased levels of GSH, SOD, GST, and IL-10, denoting oxidative and inflammatory responses. The necroptosis-related proteins RIP1, RIP3, MLKL, and caspase-8 were upregulated in CIS-treated rats. AZM effectively prevented lung tissue injury, ameliorated oxidative stress and NF-κB p65 and pro-inflammatory markers levels, boosted antioxidants and IL-10, and downregulated necroptosis-related proteins in CIS-administered rats. AZM decreased the concentration of Ang II and increased those of Ang (1-7), cytoglobin, PPARγ, SIRT1, Nrf2, and HO-1 in the lungs of CIS-treated rats. In conclusion, AZM attenuated the lung injury provoked by CIS in rats through the suppression of inflammation, oxidative stress, and necroptosis. The protective effect of AZM was associated with the upregulation of Nrf2/HO-1 signaling, cytoglobin, PPARγ, and SIRT1.
Sleep is something, not nothing: an interprofessional approach to sleep assessment and treatment to support substance use recovery

ABSTRACT Many people with substance use disorders experience significant sleep disturbances that impact their pursuit of short- and long-term recovery goals, and overall health. Consistent rest and sleep routines contribute to effective functioning in daily life activities, overall health and wellness for people in early and long-term recovery. Despite the benefits, sleep and rest is not addressed by behavioral healthcare professionals in treatment settings. This manuscript illustrates how occupational therapists and social workers can collaborate to use sleep assessments to guide treatment. Addressing rest and sleep preparation and participation using a person-centered approach can have a profound impact on early and long-term recovery, quality of life for people with substance use challenges.
Extended X-Ray-Absorption Fine Structure of Surface Atoms on Single-Crystal Substrates: Iodine Adsorbed on Ag(111)

An Auger variant of the x-ray--absorption fine-structure (EXAFS) technique has been successfully applied to study the adsorption site and adsorbate-substrate bond length in a single-crystal system. The surface-EXAFS technique should have widespread applications in surface crystallographic studies.
Two electrons in an external oscillator potential: exact solution versus one-particle approximations

We use the two-electron oscillator (with Coulomb interaction between the electrons) as a test system for a selection of the most common one-particle approximations: Hartree-Fock (HF), local spin density approximation (LSDA), with self-interaction correction (SIC), generalized gradient correction (GGA) and corrections for excitation energies. Moreover we compared excitation energies from total energy differences with the concept of the Slater transition state (STS) and with the difference of approximate and exact Kohn-Sham energies. By tuning the external oscillator frequency, one can realize the strong, intermediate and weak correlation regime within one system. The results are compared with exact charge densities, Kohn-Sham potentials, ground-state energies and excitation energies. Unlike previous papers on this model, we used self-consistent (and not the exact) charge densities as input for the density functional theory, which makes it possible to check the accuracy of the approximated density itself. We found that the LSDA describes the charge density even in the Wigner crystal limit qualitatively correct, although only SIC provides quantitatively satisfactory results. For all oscillator frequencies, the spurious wiggles in the GGA exchange potential are located near the classical turning point suggesting that they are a consequence of the divergence of the underlying Kirshnitz expansion in this region. It is also observed that the well known large error in the LSDA and GGA exchange potential is not present in self-interaction free methods such as HF and SIC giving rise to the assumption that self-interaction is responsible for this defect. KS eigenvalue differences (as zeroth approximations for excitation energies) calculated from the exact and LSDA effective potential are very close. Therefore, their common large difference with the exact excitation energies cannot be fixed by nonlocal corrections to the LSDA.
Development of a probe for inner profile measurement and flaw detection

It is one of the important necessities to precisely measure the inner diameter and/or the inner profile of pipes, tubes and other objects similar in shape. Especially in mechanical engineering field, there are many requests from automobile industry because the inner surface of engine blocks and other die casts are strongly required to be inspected and measured by non-contact methods (not by the naked eyes inspection using a borescope). If the inner diameter is large enough like water pipes or drain pipes, complicated and large equipment may be applicable. However, small pipes with a diameter ranging from 10mm to 100mm are difficult to be inspected by such a large instrument as is used for sewers inspection. And we have proposed an instrument which has no moving elements such as a rotating mirror or a prism for scanning a beam. Our measurement method is based on optical sectioning using triangulation. This optically sectioned profile of an inner wall of pipe-like objects is analyzed to produce numerical data of inner diameter or profile. Here, we report recent development of the principle and applications of the optical instrument with a simple and compact configuration. In addition to profile measurement, we found flaws and defects on the inner wall were also detected by using the similar principle. Up to now, we have developed probes with the diameter of 8mm to 25mm for small size objects and another probe (80 mm in diameter) for such a larger container with the dimensional size of 600mm.
Corosolic Acid Inhibits Secretory Phospholipase A2IIa as an Anti-Inflammatory Function and Exhibits Anti-Tumor Activity in Ehrlich Ascites Carcinoma Bearing Mice

Background Inflammation is generally connected to tumour progression and development. The secretory phospholipase A2IIa (sPLA2IIa) is an important inflammatory enzyme that catalyse the hydrolysis of membrane phospholipids into arachidonic and lysophosphatidic acid, which are the precursors for production of a lot of pro-inflammatory mediators like prostaglandins, prostacyclins, thromboxanes, leukotrienes and platelet activating factors, which involved in the proliferation, migration, invasion, and metastasis. Therefore, investigating safe and effective sPLA2IIa inhibitors as a therapeutic agent to treat cancer is indeed in need. Methods Anti-inflammatory function of corosolic acid was evaluated by docking it with sPLA2IIa enzyme, sPLA2IIa inhibition, calcium and substrate concentration-dependent assays; intrinsic fluorescence and UV-CD analysis; neutralisation of sPLA2IIa induced indirect hemolytic and edema. Evaluated the anticancer activity of corosolic acid by MTT assays and caspase-3 expression; the anti-tumour activity by EAC-induced cell line and interleukin 6 expression. Results The corosolic acid inhibits sPLA2IIa activity to 82.21±2.82%. The inhibition was evaluated by increasing calcium from 2.5 to 15 µM and substrate from 20 to 120 nM, it did not affect the level of inhibition. Corosolic acid altered the intrinsic fluorescence and UV-CD spectra of sPLA2IIa enzyme, indicating the direct interaction. It neutralised sPLA2IIa induced hemolytic activity from 97±1.23% to 15.75±1.44% and edema from 171.51±2.39% to 119.3±2.6%. Further, as antiproliferative activity, corosolic acid reduced the PC3 cell viability from 99.66±0.57% to 23±2.64% and suppressed LPS-induced IL-6 level from 94.35±2.2% to 34.36±2.4%. It increased mean survivability time from 30 to 38 days and displayed the drug-like qualities. Conclusion All the experimental results have proven the corosolic acid as an anti-inflammatory and anticancer molecule that may further be used to develop it as a drug.
Forest roads: regional perspectives from around the world

ABSTRACT This paper reviews the IUFRO lecture series, Forest Roads: regional perspectives from around the world. In reviewing the presentations in this series, we found that regional factors such as geology, historic climate (glaciation), current climate, topography, and ownership strongly affect forest road networks. In addition to these regional factors, it appears that historic land use affects road design and construction. We define three road classifications: pioneer, mature, and plantation. In a pioneer road network, there is an existing forest resource and no established road network. A pioneer road network strongly reflects the current regulatory environment, current harvesting systems, and regional factors. A plantation road network occurs where there is a land use change, often from agriculture to forestry, and often growing non-native species. Plantation road networks evolve from existing rudimentary roads to road networks planned specifically for a well-defined forest resource. The plantation road network does reflect the existing regulations and harvesting systems; however, it does exist in a more constrained system that is defined by the existing roads and the boundaries of the planted forest. Mature forest road networks have evolved over centuries and incorporate historic and current land use, evolving regulations and technology, and are often interconnected with public roads. Responses specific to these road classes include a pioneer road network using brush mats to help support the subgrade, a plantation road network applying an optimized design, and a mature road network using pavement as the road surface.
Evidence for a Dense, Cold Screen towards IRAS 18507+0121

Self-absorbed profiles has been seen towards the core containing IRAS 18507+0121, a probable highmass protostar, in the millimeter wave lines of HCO +, H13CO+, CS, and C34S. Especially, the J = 1 —• 0 line of H 13CO+ is found to be stronger than that of HCO +. We have modeled this core in order to deter­ mine the physical conditions in it. To generate synthetic spectra from the model core, we used a multi-level, non-LTE radiative transfer code that employs a large-velocity -gradient approximation in order to estimate the level populations. It has been demonstrated that the line profiles can be explained by a collapsing hot core hidden behind a cold (~ 4 K) and dense (3 x 104 cm -3 ) intervening, but comoving, screen or envelope. The model parameters adjusted to reproduce the observed profiles are (a) the temperature, density, and velocity fields in the model core and (b) the temperature, density, and linewidth in the screen. Comparing the observed profiles with the model spectra at both the on-center and one off-center positions, we have been able to reliably determine the physical conditions in the core.