Miracle-dz/UniFAR-FTUs huggingface dataset:
L'Inventaire d'anxiété situationnelle et de trait d'anxiété (IASTA-Y): structure factorielle et biais linguistique

La structure factorielle de l'Inventaire d'anxiete situationnelle et de trait d'anxiete (IASTA-Y; Gauthier & Bouchard, 1993), version canadienne de langue francaise du State-Trait Anxiety Inventory, forme Y (STAI-Y; Spielberger et al., 1983), est, comme celle de l'instrument original americain, source de discussions. Si la structure a deux facteurs prevue par la theorie ― un facteur d'anxiete situationnelle et un autre de trait d'anxiete - est parfois verifiee dans les etudes sur le sujet, une structure a quatre facteurs a egalement ete proposee, resultat du croisement de la structure originale etat-trait et d'une distinction entre presence et absence d'anxiete. Dans la presente etude, la structure factorielle de l'IASTA-Y a ete examinee a l'aide de l'analyse factorielle confirmatoire aupres d'un echantillon de 361 etudiants universitaires. Les resultats indiquent que la qualite de l'ajustement de la solution en quatre facteurs est superieure a celle de modeles plus simples. Cependant, les resultats indiquent egalement que l'intercorrelation des scores correspondant a ces facteurs (anxiete situationnelle ― items positifs; anxiete situationnelle - items negatifs; trait d'anxiete ― items positifs; trait d'anxiete - items negatifs) varie en fonction du niveau d'aptitude verbale des sujets, ce qui revele la presence d'un biais linguistique dans l'instrument.
A Study of Implementation of Madeline Hunter's Model and Its Effects on Students

AbstractThis article reports the results of a Madeline Hunter program implementation study. The study was conducted by the NAPA County Unified School District as one of the NTE-funded Follow Through grants. The research sought to identify the relationships between staff development programs, teacher implementation of the program, students’ engaged rates, and student achievement. This article reports the findings at the completion of the first full year of data collection.The sample includes 13 teachers in two schools representing two school districts. All of the teachers were observed before and after a three-month intervention where the Madeline Hunter five-step lesson plan was taught. The 257 students included in the analyses have pretest and posttest scores for observed engaged rates and achievement tests in both reading and mathematics.The correlational results suggest a significant relationship between program implementation and engaged rate in both reading ip < . 05) and mathematics ip < . 01). Progra.
Reconstructing the orientation distribution of actin filaments in the lamellipodium of migrating keratocytes from electron microscopy tomography data

Migration of motile cells on flat substrates is usually driven by the polymerization of a flat actin filament network. Theoretical models have made different predictions regarding the distribution of the filament orientation in the lamellipodium with respect to the direction of motion. Here we show how one can automatically reconstruct the orientation distribution of actin filaments in the lamellipodium of migrating keratocytes from electron microscopy tomography data. We use two different image analysis methods, an algorithm which explicitly extracts an abstract network representation and an analysis of the gray scale information based on the structure tensor. We show that the two approaches give similar results, both for simulated data and for electron microscopy tomography data from migrating keratocytes. For the lamellipodium at the leading edge of fast moving cells, we find an orientation distribution that is peaked at +35/−35 degrees. For the lamellipodium at the leading edge of slow moving cells as well as for the lamellipodium at the flanks of fast moving cells, one broad peak around 0 degree dominates the distribution. © 2012 International Society for Advancement of Cytometry
Motivation, commitment, and intentions of volunteers at a large Canadian sporting event

Abstract The purpose of this study was to examine volunteer motivation, commitment, and intentions to remain as volunteers at the 2005 BMO Canadian Women's Golf Championship. Volunteers (n = 647) responded to the Organizational Commitment Questionnaire (Mowday, Porter, & Steers, 1982), volunteer motivation questionnaire (Strigas & Jackson, 2003a), and qualitative questions regarding intention to remain volunteers. Results indicated that commitment was related to sport specific factors of the particular event; however, motivation to volunteer was associated with being part of the community. A number of factors and relationships between the variables and intentions to remain volunteering were identified. Descriptive statistics indicated that most of the volunteers intended to continue as golf volunteers (97.5%), would volunteer with other sport events (76.4%), and were likely to continue volunteering in general (83.3%). A variety of rationales were discussed. Understanding the factors that impact motivations and commitment, and the relationships between intentions and motivation/commitment to volunteer can help event organizers target volunteer recruitment and retention strategies.
Vortex tube formation in solar turbulent convection By

Turbulent solar convection is a source of various processes observed as large-scale active phenomena, e.g., coronal mass ejections, formation of self-organized magnetic structures that appear on the surface as sunspots and pores, and other non-linear dynamical structures and phenomena. Modern realistic numerical simulations of solar turbulent phenomena are based on first physical principles and take into account the real-gas equation of state, radiative transfer, chemical composition, and effects of magnetic fields. The physical description of the dynamical properties of solar convection can be improved through implementation of subgrid-scale turbulence models, which make numerical models more realistic and allow us to resolve essential physical scales. This approach has demonstrated good agreement of numerical modeling results with observations (e.g. Jacoutot et al. 2008). Realistic 3D numerical simulations have also reproduced and explained many observed effects in sunspots and magnetic active regions (e.g., Kitiashvili et al. 2009, 2010; Rempel et al. 2011; Stein et al. 2011), and in quiet-Sun regions (Stein & Nordlund 2000; Steiner et al. 2010; Kitiashvili et al. 2011). Thus, the numerical simulations provide important insights into the physical mechanisms of solar phenomena. Vorticity is one of the basic properties of turbulent flows. Therefore it is not surprising that swirling motions are found in observations of the highly-turbulent solar magnetoconvection. Large-scale vortical behavior, once evidenced by sunspot rotation, was first observed on the Sun by Secchi (1857). Later, vortex flows in the photosphere (∼ 3 Mm in diameter) were detected by Brandt et al. (1988), and small-scale swirling flows (∼ 0.5 Mm) were observed by Wang et al. (1995). Recent observations have shown that vortices are ubiquitous in non-magnetic quiet-Sun regions (Pötzi & Brandt 2005; Bonet et al. 2008, 2010). Such swirling motions correspond to vertically oriented vortex tube structures that were found in numerical simulations (e.g., Brandenburg et al. 1996; Stein & Nordlund 2000; Kitiashvili et al. 2011). Both observations and simulations have shown that vortex tubes play a fundamental role in solar flux dynamics. Also, recently, small-scale horizontal vortex tubes located along granule edges were found both in numerical simulations and in observations with the balloon observatory SUNRISE (Steiner et al. 2010). However, even the highest resolution observations are not capable of resolving the structure of the vortex tubes. Thus it is important to investigate in detail the mechanism of their formation and dynamics using high-resolution numerical simulations. Vortex tube formation can occur from several different mechanisms. According to our numerical simulations, vertical vortex-tube generation on the Sun can be driven
Blood factor in acute disseminated lupus erythematosus; induction of specific antibodies against L. E. factor.

Abstract The gamma globulin fractionated by the Tiselius electrophoretic technic from the plasma of patients with acute disseminated lupus erythematosus was used as an antigen to induce antibodies in rabbits. Similarly, antibodies were induced in control rabbits with normal human serum and with normal human gamma globulin. The antisera developed in these three groups of rabbits were added to the L. E. gamma globulin solution and, after precipitation, the supernatant fluid was added to bone marrow preparations. The L. E. phenomenon was not demonstrable after the L. E. gamma globulin was precipitated by anti-L. E. gamma globulin rabbit serum. However, after precipitation of the L. E. gamma globulin by anti-normal human serum rabbit serum, or by anti-normal human gamma globulin rabbit serum, the L. E. phenomenon was still apparent. These studies suggest that the L. E. factor is an immunologically distinct component of L. E. gamma globulin.
An equivalent electrical model for numerical analyses of ODEP manipulation

Opticaldielectrophoresis(ODEP)has been explored experimentally with success in manipulating microscale objects in the last 5 years. However, not much theoretical analyses have been performed to understand its operating principles in depth and also determine its limitations as a tool to manipulate micro- and nano-scale objects. In this paper, we present our work on establishing an equivalent electrical model to analyze the important physical interactions when optically induced dielectrophoretic force is used to manipulate micron-sized polystyrene beads. Simulation results show that the ODEP manipulation of microbeads is frequency-dependent and that the electrothermal effect is negligible. Furthermore, the relationship between the frequency of the applied voltage and the maximum manipulation velocity of the microbeads obtained from simulation is consistent with our experimental measurements. In addition, simulation results also show that the minimum radius of a bead that can be manipulated exponentially decreases with respect to the size of the illuminated spot. For instance, when the illuminated spot size is 1µm, ODEP can theoretically manipulate 100nm beads - indicating that ODEP can be extended to manipulate nano-scale objects if the illuminated spot size can be significantly reduced.
Engineering Yarrowia lipolytica as a platform for synthesis of drop-in transportation fuels and oleochemicals

Significance Cost-efficient production of fuels and oleochemicals requires the host strain to be highly lipogenic and suitable for large-scale production. We demonstrate that Yarrowia lipolytica represents a promising biorefinery platform for sustainable production of drop-in transportation fuels and oleochemicals. Understanding the mechanistic details of the lipogenic phenotype, particularly the cellular compartmentalization of distinct metabolic pathways, fatty acid synthase structure, activating free fatty acids to acyl-CoAs, and decoupling nitrogen starvation from lipogenesis, allowed us to efficiently produce fatty acid ethyl esters, fatty alkanes, medium chain-length fatty acids, fatty alcohols, and triacylglycerides (TAGs). We envision that this report constitutes foundational work in developing an oleaginous yeast platform to upgrade low-value carbons to high-value fuels and oleochemicals in the foreseeable future. Harnessing lipogenic pathways and rewiring acyl-CoA and acyl-ACP (acyl carrier protein) metabolism in Yarrowia lipolytica hold great potential for cost-efficient production of diesel, gasoline-like fuels, and oleochemicals. Here we assessed various pathway engineering strategies in Y. lipolytica toward developing a yeast biorefinery platform for sustainable production of fuel-like molecules and oleochemicals. Specifically, acyl-CoA/acyl-ACP processing enzymes were targeted to the cytoplasm, peroxisome, or endoplasmic reticulum to generate fatty acid ethyl esters and fatty alkanes with tailored chain length. Activation of endogenous free fatty acids and the subsequent reduction of fatty acyl-CoAs enabled the efficient synthesis of fatty alcohols. Engineering a hybrid fatty acid synthase shifted the free fatty acids to a medium chain-length scale. Manipulation of alternative cytosolic acetyl-CoA pathways partially decoupled lipogenesis from nitrogen starvation and unleashed the lipogenic potential of Y. lipolytica. Taken together, the strategies reported here represent promising steps to develop a yeast biorefinery platform that potentially upgrades low-value carbons to high-value fuels and oleochemicals in a sustainable and environmentally friendly manner.
Solution Structure of an Arabidopsis WRKY DNA Binding Domainw⃞

The WRKY proteins comprise a major family of transcription factors that are essential in pathogen and salicylic acid responses of higher plants as well as a variety of plant-specific reactions. They share a DNA binding domain, designated as the WRKY domain, which contains an invariant WRKYGQK sequence and a CX4–5CX22–23HXH zinc binding motif. Herein, we report the NMR solution structure of the C-terminal WRKY domain of the Arabidopsis thaliana WRKY4 protein. The structure consists of a four-stranded β-sheet, with a zinc binding pocket formed by the conserved Cys/His residues located at one end of the β-sheet, revealing a novel zinc and DNA binding structure. The WRKYGQK residues correspond to the most N-terminal β-strand, kinked in the middle of the sequence by the Gly residue, which enables extensive hydrophobic interactions involving the Trp residue and contributes to the structural stability of the β-sheet. Based on a profile of NMR chemical shift perturbations, we propose that the same strand enters the DNA groove and forms contacts with the DNA bases.
The difference in the low frequency sound propagation across the North Pacific sound communication in various species of baleen whales

Possibility of long distance sound communication in various species of baleen whales is investigated by simulating the long range propagation of their sound transmission between the coast of Alaska and the Island of Hawaii. In the simulation, the parabolic equation (PE) method is applied to the actual sound speed profiles and underwater topography along the propagation path over typical transmission frequency bands of baleen whales. The simulation demonstrates that the higher possibilities of long distance sound communication of both fin whales and blue whales when using the deep sound channel. It is also indicated that among fin whales and among blue whales the communication across the North Pacific can be made by their coming close to shore slopes of the Island of Hawaii
Comparison of Caregiver and Occupational Therapist Ratings of Dementia Patients' Performance of Activities of Daily Living

Although proxy reports of activities of daily living (ADLs) are commonly used, especially when the care recipient has dementia, how well these caregiver reports correspond to professionals' ratings is not always clear. In this study, dementia caregivers completed an orally administered version of the Self-Care subscale of the Functional Independence Measure (FIM). ADL interactions were videotaped in the home, and independent raters assigned a FIM score to these interactions. An occupational therapist later viewed the videotaped ADLs and assigned FIM scores to those interactions. These three sets of scores were then compared. All possible correlations were significant (n = 21; p ≤ .005; r s = .620 to .933; Mdn = .862), and there were no significant differences among ratings obtained from the different sources. These results support earlier conclusions regarding the validity and clinical utility of caregiver proxy ratings of functional ability in elders with dementia.
The University of Michigan in Novelty 2004

This year we participated in the Novelty track. To (cid:2)nd the relevant sentences, we combine sentence salience features that are inherited from text summarization domain with other heuristic features based on topic statements. We propose a novel method to extract the new sentences based on the graph-based ranking of the similarity relation between the sentences.
CXL-1020, a Novel Nitroxyl (HNO) Prodrug, Is More Effective than Milrinone in Models of Diastolic Dysfunction—A Cardiovascular Therapeutic: An Efficacy and Safety Study in the Rat

The nitroxyl (HNO) prodrug, CXL-1020, induces vasorelaxation and improves cardiac function in canine models and patients with systolic heart failure (HF). HNO's unique mechanism of action may be applicable to a broader subset of cardiac patients. This study investigated the load-independent safety and efficacy of CXL-1020 in two rodent (rat) models of diastolic heart failure and explored potential drug interactions with common HF background therapies. In vivo left-ventricular hemodynamics/pressure-volume relationships assessed before/during a 30 min IV infusion of CXL-1020 demonstrated acute load-independent positive inotropic, lusitropic, and vasodilatory effects in normal rats. In rats with only diastolic dysfunction due to bilateral renal wrapping (RW) or pronounced diastolic and mild systolic dysfunction due to 4 weeks of chronic isoproterenol exposure (ISO), CXL-1020 attenuated the elevated LV filling pressures, improved the end diastolic pressure volume relationship, and accelerated relaxation. CXL-1020 facilitated Ca2+ re-uptake and enhanced myocyte relaxation in isolated cardiomyocytes from ISO rats. Compared to milrinone, CXL-1020 more effectively improved Ca2+ reuptake in ISO rats without concomitant chronotropy, and did not enhance Ca2+ entry via L-type Ca2+ channels nor increase myocardial arrhythmias/ectopic activity. Acute-therapy with CXL-1020 improved ventricular relaxation and Ca2+ cycling, in the setting of chronic induced diastolic dysfunction. CXL-1020's lusitropic effects were greater than those seen with the cAMP-dependent agent milrinone, and unlike milrinone it did not produce chronotropy or increased ectopy. HNO is a promising new potential therapy for both systolic and diastolic heart failure.
A Survey on Active Queue Management Techniques

With the fast growth of current internet and service demand for multiple access has also been increased significantly. Therefore, there is huge traffic in the network which results in congestion where buffer management acts an important role. Earlier, drop tail and random drop were used as buffer management techniques with the TCP. Drop tail suffers from huge queuing delay, lockout, global synchronization problem. To overcome all these problems with earlier techniques active queue management(AQM) technique has been introduced. In active queue discipline packets are dropped or marked before buffer becomes full while in earlier technique does the same when buffer becomes full. We have various algorithms under the AQM as Random early detection(RED), Random Exponential Marking (REM), Blue and Stochastic Fair Blue (SFB), ARED, Re RED, PI controller, Robust random early detection (RRED), RED with Preferential Dropping (RED-PD) etc. In this paper, we will perform the literature survey on the queue management and congestion control in the network.
Advancing a Framework for Coherent Research on Women's Entrepreneurship

Current entrepreneurship theory is organised around three basic constructs, namely market, money and management. Specifically, to launch and grow a venture, an entrepreneur needs to have access to markets, money (financial resources) and management (human and organizational capital). Drawing on institutional theory, this paper argues that in order to study women's entrepreneurship, this '3M' framework needs to be modified by including motherhood and the meso as well as the macro environments. 'Motherhood' represents the micro household/family context, which might have a larger impact on women than men, thus highlighting the embeddedness of female entrepreneurs. The meso environment includes the factors which concern intermediate structures and institutions such as occupational networks; all of which in turn affect the access of women to 'money' and 'market'. The macro environment includes considerations beyond the market, such as expectations of society and cultural norms, national strategies and initiatives. This new '5M' perspective (with meso/macro considered as one additional M) offers a 'gender adequate' framework that allows the study of women's entrepreneurship in its own right, and also brings into focus appropriate approaches for its study. As a foundation for this framework, we review academic publications on women's entrepreneurship using the 5M approach. We elaborate this framework and suggest future research directions for women's entrepreneurship. For the academic research community, the 5M framework developed in this paper helps lay a foundation for coherent research on women's entrepreneurship because it takes into account the social embeddedness of women entrepreneurs and considers the multiple levels of influence on their entrepreneurial actions. For the woman entrepreneur, this analysis has implications for understanding the sources of the challenges they face by providing insights on the importance of the interplay of both individual and societal factors that impact on their enterprise. For policy makers, it turns the spotlight on the need for an integrated approach for fostering female entrepreneurs that is not blind to overarching institutionalised social structures and gender asymmetries.
Positive Regulation of Apoptosis Signal-regulating Kinase 1 Signaling by ZPR9 Protein, a Zinc Finger Protein*

A zinc finger protein, ZPR9, has been identified as a physiological substrate of murine protein serine/threonine kinase 38 (MPK38), which is involved in various cellular responses, including the cell cycle, apoptosis, embryonic development, and oncogenesis. Here, ZPR9 was found to physically interact with apoptosis signal-regulating kinase 1 (ASK1) through a disulfide linkage involving Cys1351 and Cys1360 of ASK1 and Cys305 and Cys308 of ZPR9. ASK1 directly phosphorylated ZPR9 at Ser314 and Thr318, suggesting that ZPR9 can act as an ASK1 substrate. Ectopic expression of wild-type ZPR9, but not an S314A/T318A mutant, stimulated ASK1 kinase activity and positively regulated ASK1-mediated signaling to both JNK and p38 kinases by destabilizing complex formation between ASK1 and its negative regulators, Trx and 14-3-3, or by increasing complex formation between ASK1 and its substrate MKK3. ZPR9 functionally stimulated ASK1-induced AP-1 transcriptional activity as well as H2O2-mediated apoptosis in a phosphorylation-dependent manner. ASK1-mediated phosphorylation of ZPR9 at Ser314 and Thr318 was also responsible for ZPR9-induced apoptosis. Moreover, ZPR9 inhibited PDK1-mediated signaling through ASK1 activation. These results suggest that ZPR9 functions as a novel positive regulator of ASK1.
When is it Acceptable to Accept a Null Hypothesis: No Way, Jose?

Previous research has suggested that there exists a bias in the social sciences against no-effect hypotheses. This is regrettable given the importance of establishing not only when an effect does occur but also the boundary conditions of that effect. The purposes of this article are two-fold The first purpose is to review relevant portions of the history of hypothesis testing in an attempt to identify the sources of bias against hypotheses of no effect. The second purpose is to develop and describe rigorous methods for providing evidence in support of no-effect hypotheses-methods that avoid some of the problems traditionally associated with no-effect conclusions.