Miracle-dz/UniFAR-FTUs huggingface dataset:
Behavioral and Neurochemical Effects of 5-{4-[4-(5-Cyano-3-indolyl)-butyl)-butyl]-1-piperazinyl}-benzofuran-2-carboxamide (EMD 68843): A Combined Selective Inhibitor of Serotonin Reuptake and 5-Hydroxytryptamine1A Receptor Partial Agonist

5-{4-[4-(5-Cyano-3-indolyl)-butyl)-butyl]-1-piperazinyl}-benzofuran-2-carboxamide (EMD 68843; vilazodone) is a novel compound with combined high affinity and selectivity for the 5-hydroxytryptamine (5-HT) transporter and 5-HT1A receptors. EMD 68843 was tested as a prototype compound, which benefits from dual pharmacological effects that could increase extracellular 5-HT to levels higher than those produced by conventional selective serotonin reuptake inhibitors (SSRIs). In Sf9 cells, EMD 68843 increased guanosine 5′-O-(3-[35S]thiotriphosphate) binding to 69% of the magnitude of the full 5-HT1A receptor agonistR-(1)-trans-8-hydroxy-2-[N-n-propyl-N-(39-iodo-29-propenyl)] aminotetralin (8-OH-PIPAT), indicating that it is a partial agonist at 5-HT1A receptors. Acute, systemic administration of EMD 68843 produced a larger maximal increase of extracellular 5-HT than the SSRI fluoxetine in both the ventral hippocampus (HPv) (558 versus 274%) and the frontal cortex (FC) (527 versus 165%). Regional differences in the response to the two drugs were also observed. These effects may be attributed to the differential regulation of 5-HT release in the HPv and FC by 5-HT1A autoreceptors. When challenged with the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), EMD 68843-induced increases in extracellular 5-HT were greatly reduced in the HPv but to a lesser extent in the FC. In behavioral studies, EMD 68843 produced antidepressant-like effects in the forced swimming test in both rats and mice but only within a narrow dosage range. Like fluoxetine, EMD 68843 did not produce the symptoms of the 5-HT behavioral syndrome in rats but, unlike fluoxetine, pretreatment with EMD 68843 blocked expression of the 5-HT behavioral syndrome induced by 8-OH-DPAT. Taken together, the results show that EMD 68843 augments extracellular 5-HT levels in forebrain regions to a greater extent than fluoxetine. At higher doses, however, weak efficacy of EMD 68843 at postsynaptic 5-HT1A receptors may inhibit the expression of rodent antidepressant-like behaviors.
The Interleukin (IL)‐2 Family Cytokines: Survival and Proliferation Signaling Pathways in T Lymphocytes

Lymphocyte populations in the immune system are maintained by a well-organized balance between cellular proliferation, cellular survival and programmed cell death (apoptosis(. One of the primary functions of many cytokines is to coordinate these processes. In particular, the interleukin (IL(‐2 family of cytokines, which consists of six cytokines ‐IL‐2, IL‐4, IL‐7, IL‐9, IL‐15 and IL‐21) that all share a common receptor subunit (gc), plays a major role in promoting and maintaining T lymphocyte populations. The details of the molecular signaling pathways mediated by these cytokines have not been fully elucidated. However, the three major pathways clearly involved include the JAK/STAT, MAPK and phosphatidylinositol 3‐kinase ‐PI3K‐ pathways. The details of these pathways as they apply to the IL‐2 family of cytokines is discussed, with a focus on their roles in proliferation and survival signaling.
Polynomial to Linear: Efficient Classification with Conjunctive Features

This paper proposes a method that speeds up a classifier trained with many conjunctive features: combinations of (primitive) features. The key idea is to precompute as partial results the weights of primitive feature vectors that appear frequently in the target NLP task. A trie compactly stores the primitive feature vectors with their weights, and it enables the classifier to find for a given feature vector its longest prefix feature vector whose weight has already been computed. Experimental results for a Japanese dependency parsing task show that our method speeded up the svm and llm classifiers of the parsers, which achieved accuracy of 90.84/90.71%, by a factor of 10.7/11.6.
Linking aging measurements of health-monitors and specifications for multi-processor SoCs

A new generation of highly dependable multi-processor Systems-on-Chip for safety-critical applications under harsh environments with zero down-time is emerging. In this paper1, the approach towards reaching this ultimate goal is explained. Crucial is this method is linking the measurement data of so-called (on-chip) health monitors during life time with the measurements of degrading key performance parameters of the cores involved. The focus will be here on processor cores, with delay as one of the most critical aging dependent parameters. An extensive (accelerated)-test program was set-up to evaluate the aging of both the health monitors as well as delay of an industrial reconfigurable processor core in harsh environments. The correlation between them will serve as the basis of real-time on-chip health-monitoring based prognostics for life-time prediction, enabling a zero down-time for safety-critical applications.
International Journal of Health Care Quality Assurance Applying Lean Six Sigma to improve medication management

Susan Knapp, (2015),"Lean Six Sigma implementation and organizational culture", International Journal of Health Care Quality Assurance, Vol. 28 Iss 8 pp. 855-863 http://dx.doi. org/10.1108/ IJHCQA-06-2015-0079 Praveen T Rajasekhar, Colin J Rees, Catherine Nixon, James E East, Sally Brown, (2016),"Factors influencing change in clinical practice: A qualitative evaluation of the implementation of the quality improvement in colonoscopy study", International Journal of Health Care Quality Assurance, Vol. 29 Iss 1 pp. 5-15 http://dx.doi. org/10.1108/IJHCQA-09-2014-0093 Tapani Jorma, Hanna Tiirinki, Risto Bloigu, Leena Turkki, (2016),"LEAN thinking in Finnish healthcare", Leadership in Health Services, Vol. 29 Iss 1 pp. 9-36 http://dx.doi. org/10.1108/ LHS-08-2015-0021
Running Head : AUTOMATIC AUDITORY AFFECT 1

Recent work has challenged the previously widely accepted belief that affective processing does not require awareness and can be carried out with more limited resources than semantic processing. This debate has focused exclusively on visual perception, even though evidence from both human and animal studies suggests that existence for nonconscious affective processing would be physiologically more feasible in the auditory system. Here we contrast affective and semantic processing of nonverbal emotional vocalizations under different levels of awareness in three experiments, using explicit (2AFC masked affective and semantic categorization tasks, Exp. 1 and 2) and implicit (masked affective and semantic priming, Exp. 3) measures. Identical stimuli and design were used in the semantic and affective tasks. Awareness was manipulated by altering stimulus-mask signal-to-noise-ratio (SNR) during continuous auditory masking. Stimulus awareness was measured on each trial using a four-point perceptual awareness scale. In explicit tasks, neither affective nor semantic categorization could be performed in the complete absence of awareness, whilst both tasks could be performed above chance level when stimuli were consciously perceived. Semantic categorization was faster than affective evaluation. When the stimuli were partially perceived, semantic categorization accuracy exceeded affective evaluation accuracy. In implicit tasks neither affective nor semantic priming occurred in the complete absence of awareness, whereas both affective and semantic priming emerged when participants were aware of the primes. We conclude that auditory semantic processing is faster than affective processing, and that both affective and semantic auditory processing are dependent on awareness.
Insulin-Mimetic Action of Rhoifolin and Cosmosiin Isolated from Citrus grandis (L.) Osbeck Leaves: Enhanced Adiponectin Secretion and Insulin Receptor Phosphorylation in 3T3-L1 Cells

Citrus grandis (L.) Osbeck (red wendun) leaves have been used in traditional Chinese medicine to treat several illnesses including diabetes. However, there is no scientific evidence supporting these actions and its active compounds. Two flavone glycosides, rhoifolin and cosmosiin were isolated for the first time from red wendun leaves and, identified these leaves are rich source for rhoifolin (1.1%, w/w). In differentiated 3T3-L1 adipocytes, rhoifolin and cosmosiin showed dose-dependent response in concentration range of o.oo1–5 μM and 1–20 μM, respectively, in biological studies beneficial to diabetes. Particularly, rhoifolin and cosmosiin at 0.5 and 20 μM, respectively showed nearly similar response to that 10 nM of insulin, on adiponectin secretion level. Furthermore, 5 μM of rhoifolin and 20 μM of cosmosiin showed equal potential with 10 nM of insulin to increase the phosphorylation of insulin receptor-β, in addition to their positive effect on GLUT4 translocation. These findings indicate that rhoifolin and cosmosiin from red wendun leaves may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4 translocation.
Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates

Summary Aggregation of misfolded proteins and the associated loss of neurons are considered a hallmark of numerous neurodegenerative diseases. Optineurin is present in protein inclusions observed in various neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), Huntington's disease, Alzheimer's disease, Parkinson's disease, Creutzfeld-Jacob disease and Pick's disease. Optineurin deletion mutations have also been described in ALS patients. However, the role of optineurin in mechanisms of protein aggregation remains unclear. In this report, we demonstrate that optineurin recognizes various protein aggregates via its C-terminal coiled-coil domain in a ubiquitin-independent manner. We also show that optineurin depletion significantly increases protein aggregation in HeLa cells and that morpholino-silencing of the optineurin ortholog in zebrafish causes the motor axonopathy phenotype similar to a zebrafish model of ALS. A more severe phenotype is observed when optineurin is depleted in zebrafish carrying ALS mutations. Furthermore, TANK1 binding kinase 1 (TBK1) is colocalized with optineurin on protein aggregates and is important in clearance of protein aggregates through the autophagy-lysosome pathway. TBK1 phosphorylates optineurin at serine 177 and regulates its ability to interact with autophagy modifiers. This study provides evidence for a ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates as well as additional relevance for TBK1 as an upstream regulator of the autophagic pathway.
Poster: Selective reference mechanism for neighbor discovery in low-duty-cycle wireless sensor networks

Based on spatiotemporal properties of neighborhood and mobile properties of nodes in the networks, we propose Selective Reference Mechanism to trade off between the delay and overhead of neighbor discovery in low-duty-cycle WSNs. Extensive simulation and test-bed experiment confirm our theoretical analysis, showing as much as 35.4% increase in discovery probability, 38.6% reduction in discovery delay and 27.7% reduction in total energy consumption.
Blind Separation of Underdetermined Convolutive Mixtures Using Their Time–Frequency Representation

This paper considers the blind separation of nonstationary sources in the underdetermined convolutive mixture case. We introduce, two methods based on the sparsity assumption of the sources in the time-frequency (TF) domain. The first one assumes that the sources are disjoint in the TF domain, i.e., there is at most one source signal present at a given point in the TF domain. In the second method, we relax this assumption by allowing the sources to be TF-nondisjoint to a certain extent. In particular, the number of sources present (active) at a TF point should be strictly less than the number of sensors. In that case, the separation can be achieved thanks to subspace projection which allows us to identify the active sources and to estimate their corresponding time-frequency distribution (TFD) values. Another contribution of this paper is a new estimation procedure for the mixing channel in the underdetermined case. Finally, numerical performance evaluations and comparisons of the proposed methods are provided highlighting their effectiveness.
Laue microdiffraction characterisation of as-cast and tensile deformed Al microwires

ABSTRACT Single-crystalline cast aluminium microwires with a diameter near 15 are characterised by Laue microdiffraction. A microwire in the as-cast condition exhibits a misorientation below over a length of 500 . The measured density of geometrically necessary dislocations is low, m−2, though local maxima up to one order of magnitude higher are found. After tensile deformation to failure, the dislocation density is significantly increased in microwires that have mostly deformed in single slip ( m−2), and yet higher when deformation has occurred by multiple slip ( m−2). In deformed single slip oriented microwires, the streaking directions of Laue spots show that dislocations are stored (though not exclusively) on the primary slip system. Results are consistent with a deformation mechanism governed by rotating, likely single-arm, sources.
Integrated inductors on silicon and planarized ceramic substrates

Passive integration is one of the important issues for system miniaturization in wireless applications on different substrate. Integrated inductors were designed and realized on both silicon and planarized ceramic substrate. Planarized ceramic substrate has the advantages such as lower cost than polished ceramic substrate and has other advantages such as lower dielectric constant, higher bulk resistance than silicon substrate. The L values of fabricated inductors on planarized ceramic substrate are about 1nH, the peak values of Q are about 30 and the corresponding frequency is about 10GHz. By contrast, for the Inductors fabricated on silicon substrate with the same process, the L values is more or less the same with those on ceramic substrate, the Q peak value is about 7 lower, the corresponding frequency is about 5GHz.
Indinavir and nelfinavir inhibit proximal insulin receptor signaling and salicylate abrogates inhibition: Potential role of the NFkappa B pathway

The molecular basis of insulin resistance induced by HIV protease inhibitors (HPIs) remains unclear. In this study, Chinese hamster ovary cells transfected with high levels of human insulin receptor (CHO‐IR) and 3T3‐L1 adipocytes were used to elucidate the mechanism of this side effect. Indinavir and nelfinavir induced a significant decrease in tyrosine phosphorylation of the insulin receptor β‐subunit. Indinavir caused a significant increase in the phosphorylation of insulin receptor substrate‐1 (IRS‐1) on serine 307 (S307) in both CHO‐IR cells and 3T3‐L1 adipocytes. Nelfinavir also inhibited phosphorylation of Map/ERK kinase without affecting insulin‐stimulated Akt phosphorylation. Concomitantly, levels of protein tyrosine phosphatase 1B (PTP1B), suppressor of cytokines signaling‐1 and ‐3 (SOCS‐1 and ‐3), Src homology 2B (SH2B) and adapter protein with a pleckstrin homology domain and an SH2 domain (APS) were not altered significantly. When CHO‐IR cells were pre‐treated with sodium salicylate (NaSal), the effects of indinavir on tyrosine phosphorylation of the IR β‐subunit and phosphorylation of IRS‐1 at S307 were abrogated. These data suggest a potential role for the NFκB pathway in insulin resistance induced by HPIs. J. Cell. Biochem. 114: 1729–1737, 2013. © 2013 Wiley Periodicals, Inc.
Macroeconomics II Lecture notes ( 5 ) on : New Keynesian Macroeconomics : imperfect competition and nominal rigidities

The traditional "keynesian" literature has often assumed the existence of rigidities in the price and/or wage setting process in order to justify the real e¤ects (on output and employment) of uctuations in aggregate demand, due for example to changes in money supply. The need to provide rigorous theoretical underpinnings to the hypothesis of nominal rigidities is the main motivation of several strands of the more recent "new keynesian macroeconomics" literature. Those e¤orts to build keynesian macroeconomics on sound microeconomic foundations are based on two important beliefs:
Electron-Ion Recombination Rate Coefficients and Photoionization Cross Sections for Astrophysically Abundant Elements. VI. Ni II

We present the first detailed ab initio quantum mechanical calculations for total and state-specific recombination rate coefficients for e + Ni III → Ni II. These rates are obtained using a unified treatment for total electron-ion recombination that treats the nonresonant radiative recombination and the resonant dielectronic recombination in a self-consistent unified manner in the close-coupling approximation. Large-scale calculations are carried out using a 49 state wavefunction expansion from core configurations 3d8, 3d74s, and 3d64p that permits the inclusion of prominent dipole allowed core transitions. These extensive calculations for the recombination rates of Ni II required hundreds of CPU hours on the Cray T90. The total recombination rate coefficients are provided for a wide range of temperature. The state-specific recombination rates for 532 bound states of doublet and quartet symmetries, and the corresponding photoionization cross sections for leaving the core in the ground state, are presented. Present total recombination rate coefficients differ considerably from the currently used data in astrophysical models. In particular the enhancement in the low-temperature recombination rate coefficient should help address the long-standing problem of Nickel overabundance in several classes of astronomical objects.
Extending the Generalised Substitution to Model Semi-decidable Operations

We consider an extension to the generalised substitution that allows us to specify semi-decidable operations. We call this new form of substitution a hypersubstitution. We propose a new parallel composition operator on hypersubstitutions, for use when two processes are both searching for the answer to a problem, and which will terminate when either process nds the answer. This new parallel composition, which we call the concert operator, has the highly desirable property of being monotonic with respect to reenement. Thus we are able to use it not only in specifying, but also in implementing an operation in terms of a number of semi-decidable sub-operations working in concert together.
Robot users for the evaluation of boundary-tracking approaches in interactive image segmentation

Recent advances in interactive image segmentation focused on eliminating the user bias during evaluation by simulating their behavior using robot users. However, these robots only work for region-based methods, excluding the important class of approaches that rely on the boundary-tracking paradigm. We propose completely novel robot users that are able to simulate the human user behavior when segmenting an image through the addition of anchor points close to the object's boundary. Our robots constantly evaluate the optimum-boundary segment being computed from a previously selected anchor point to the current virtual mouse position, seeking for the longest possible segment with minimum acceptable error. A new anchor is added when the error is too high and the robots iterate until closing the contour, just like real users. We validate our robots by conducting a user study and extensive experiments, considering two boundary-tracking methods: live-wire-on-the-fly and Riverbed. We further show how our robot users can be used to assess hybrid approaches that combine boundary-tracking with region-based delineation, such as LiveMarkers, while conjecturing that robots might lead to new methods for automatic foreground segmentation.
Structure and replication of the genome of hepatitis delta virus.

Abstract The hepatitis delta virus can be found in the serum and liver of some hepatitis B virus patients. We now report that the RNA genome of serum-derived delta virus is single-stranded and circular. Livers of infected chimpanzees or woodchucks contained as many as 300,000 copies of genomic strand RNA per average cell, and at least some of this RNA had a circular conformation. Also present in the livers were RNA species complementary to the virion RNA. The genomic RNA was 5-22 times more abundant than this antigenomic strand. Some of the antigenomic RNA was complexed with genomic RNA, as evidenced by the fact that at least 34% of the antigenomic RNA was resistant to digestion with either RNase A in 0.3 M NaCl or S1 nuclease. Some of the antigenomic RNA was in a circular conformation. These and other findings showed that the structure and replication of hepatitis delta virus are in many ways similar to those of the previously described plant viroids, virusoids, and satellite RNAs.
Relative Observability and Coobservability of Timed Discrete-Event Systems

We study supervisory control of timed discrete-event systems (TDES) under partial observation, and propose new observability concepts effective for supervisor synthesis. First, we consider monolithic/centralized supervisory control, and introduce timed relative observability and timed relative weak observability. The former concept extends our previous work to the timed case, while the latter exploits choices of forcible events to preempt the clock event tick. We prove that timed relative (respectively, weak) observability is stronger than timed (respectively, weak) observability, weaker than normality, and closed under set union; hence there exists the supremal relatively (respectively, weakly) observable sublanguage of a given language.
Online multiple object tracking with the hierarchically adopted GM-PHD filter using motion and appearance

This paper presents an online multiple object tracking (MOT) method based on tracking by detection. Tracking by detection has the inherent problems by false and miss detection. To deal with the false detection, we employed the Gaussian mixture probability hypothesis density (GM-PHD) filter because this filter is robust to noisy and random data processing containing many false observations. Thus, we revised the GM-PHD filter for visual MOT. Also, to handle miss detection, we propose a hierarchical tracking framework to associate fragmented or ID switched tracklets. Experiments with the representative dataset PETS 2009 S2L1 show that our framework are effective to decrease the errors by false and miss detection, and real-time capability.