Miracle-dz/UniFAR-FTUs huggingface dataset:
Height, body weight, and risk of prostate cancer.

Using data from the Health Professionals Follow-Up Study, we prospectively examined the relationships between height, body mass index, waist and hip circumferences, and risk of total and advanced (extraprostatic and metastatic) prostate cancer. In addition, we assessed adiposity during childhood, adolescence, and early, middle, and late adulthood using pictograms in relation to prostate cancer risk. Between 1986 and 1994, 1,369 cases of prostate cancer (excluding stage A1) were confirmed in 47,781 men. Adult body mass index and waist and hip circumferences were not appreciably related to risk of total prostate cancer or advanced prostate cancer. In contrast, preadult (age 10) obesity assessed in 33,336 men in 1988 was prospectively related to lower risk of advanced [relative risk (RR) = 0.72 with 95% confidence interval (CI) = 0.47-1.10, between high and low quintiles; P(trend) = 0.06] and metastatic prostate cancer (RR = 0.38 with 95% CI = 0.19-0.77; P(trend) = 0.004). For the advanced lesions, an association was observed with height (RR = 1.68 with 95% CI = 1.16-2.43 for men 74 inches or taller, relative to men 68 inches or shorter; P(trend) = 0.01). In an analysis limited to particularly aggressive forms of prostate cancer, i.e., cases found to be metastatic at time of diagnosis between 1988 and 1994 after a negative digital rectal examination in 1988, we found that obesity at ages 5 and 10 had a strong inverse association (RR = 0.16 with 95% CI = 0.05-0.54, between high and low quintiles at age 10) and that tallness had a strong direct association with risk of metastatic disease (RR = 2.29 with 95% CI = 1.04-5.05, for height > or = 74 inches versus < or = 68 inches). Our findings suggest that the preadult hormonal milieu, as reflected in attained height and childhood obesity, may have a strong influence on prostate carcinogenesis.
A new approach for channel equalization without guard interval using polyphase matrices

In this contribution we propose a new way to state and solve the channel equalization problem for an OFDM (orthogonal frequency division multiplexing) system, without the use of a guard interval. Therefore, the spectral efficiency is increased. The approach is based on the channel representation as a polynomial matrix. We develop a new decomposition of this matrix, which diagonalizes the channel matrix independently of the channel realization. It leads to a simple inversion of the channel matrix. The decomposition consists of forward and inverse DFTs and polynomial diagonal matrices. Further on, there is no restriction on the length of the channel impulse response
Low fT3 is associated with diminished health-related quality of life in patients with acute coronary syndrome treated with drug-eluting stent: a longitudinal observational study

Acute coronary syndrome (ACS) patients with low triiodothyronine (T3) syndrome characterized by low free T3 (fT3) levels with normal thyroxine (T4) and thyroid-stimulating hormone (TSH) have a higher rate of death. The impact of fT3 on Health related quality of life (HRQOL) in patients with ACS is still unknown. 528 ACS patients treated with drug-eluting stent (DES) were included in this prospective, observational study. Patients were classified into low fT3 group (n=126) and normal fT3 group (n=402) according to serum fT3 level. Every patient was prospectively interviewed at baseline and 1 year following percutaneous coronary intervention (PCI). HRQOL was assessed with the use of the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). Low fT3 patients had poorer HRQOL than normal fT3 patients both at baseline and 1-year follow-up (all p<0.05). During 1-year follow-up, HRQOL scores for all patients were significantly higher than baseline. Low fT3 patients had lesser gains in physical functioning, bodily pain, general health, vitality, social functioning and role emotional (all p<0.05). Generally, low fT3 patients demonstrated less improvement in Physical Component Score (PCS) (p=0.008) and Mental Component Score (MCS) (p=0.001). The percentage of patients reaching MCID for PCS and MCS was lower in low fT3 group than that in normal fT3 group (p<0.001). Multivariate linear regression analyses showed that low level of fT3 was an independent risk factor for PCS and MCS improvements. In conclusion, a low fT3 level is a predictor of worse HRQOL improvement in ACS patients treated with DES.
B‐lymphocyte contributions to human autoimmune disease

Summary: Autoimmunity results from abnormal B‐ and T‐cell recognition of self‐antigens, which leads to autoantibody production in many cases. Autoantibodies produced by B‐cell‐derived plasma cells provide diagnostic markers for autoimmunity but also contribute significantly to disease pathogenesis. As discussed in this review, the therapeutic benefit of depleting B cells in mice and humans has refocused attention on B cells and their role in autoimmunity beyond autoantibody production. B cells specifically serve as cellular adjuvants for CD4+ T‐cell activation, while regulatory B cells, including those that produce interleukin‐10 (B10 cells), function as negative regulators of inflammatory immune responses. The emerging picture is that B cells, autoantibodies, and T cells are all important components of abnormal immune responses that lead to tissue pathology unique to each autoimmune disease, with their relative contributions changing during disease progression. Autoimmune diseases where B‐cell functions are closely correlated with disease activity include systemic lupus erythematosus, rheumatoid arthritis, scleroderma, type 1 diabetes, and multiple sclerosis. Understanding the overlapping roles of B cells as mediators of autoimmune disease will facilitate the development of more precisely directed therapies and combination therapies with broader clinical efficacy than current depletion strategies that remove all B cells.
Effect of Age and Sex on Liver Damage Due to Excess Dietary Copper in Fischer 344 Rats

Objective: The aim of this study was to investigate the morphologic and biochemical effects of excess dietary copper in young and adult rats of different sex. Methods: Adult Fischer 344 male and female rats were given a diet containing 1500 ppm copper for 18 weeks. Young male and female rats were fed a similar copper-loaded diet from birth until 16 weeks of age. Age- and sex-matched control rats were fed a normal rodent diet (<10 ppm copper). Serum liver enzyme activity was determined in all rats. Livers were sampled for histology, histochemistry (rhodanine), immunohistochemical detection of metallothionein and copper analysis by atomic absorption spectrophotometry. Hepatic metallothionein and zinc concentrations were measured in adult rats. Results: Excess dietary copper caused substantial liver injury, as evidenced by morphologic changes and increased activity of serum ALT, GGT, and SDH. All copper-loaded rats had significantly (p< 0.05) increased hepatic copper concentrations compared to controls. However, young copper-loaded rats accumulated more hepatic copper, had more severe liver changes, and had higher serum liver enzyme activities than adult rats. Histologic changes in copper-loaded rats consisted of multifocal hepatitis and widespread single-cell necrosis. Cytoplasmic copper was detected histochemically in centroacinar zone 1 (portal) and midzone in copper-loaded rats. Immunoreactivity for metallothionein was prominent in necrotic hepatocytes and within inflammatory foci in copper-loaded rats. However, differences in hepatic metallothionein concentrations were not detected between adult copper-loaded and control rats. Conclusions: Young Fischer 344 rats are more susceptible than adults to copper-induced liver injury.
Why two kinds of stamens in buzz‐pollinated flowers? Experimental support for Darwin's division‐of‐labour hypothesis

Summary 1. Most animal-pollinated flowering plants offer nectar as a reward for their pollinators. Some 20 000 species, however, offer only pollen and rely on pollen-foraging bees for pollination. This creates a dilemma since pollen grains contain the male gametes and should be protected from becoming bee food. Darwin was the first to hypothesize that a ‘division-of-labour’ among stamens could solve this dilemma, with some stamens providing pollen as food, others providing pollen for fertilization. This hypothesis can only be tested if pollen grains from the two sets of stamens can be distinguished and their fates determined to the point of attachment on the stigma. 2. We tested Darwin’s hypothesis in Melastoma malabathricum (Melastomataceae), a pollen-only flower with conspicuously differentiated stamens, an inner set that is short and yellow and an outer set that is much longer and purple with small yellow spurs. Pollen release is through terminal anther pores. Taking advantage of different exine patterns on the pollen produced by the two sets of stamens, we carried out a series of experimental manipulations to compare pollinator foraging behaviour and pollen pathways from anthers to stigmas. 3. The results demonstrate that in spite of all 10 stamens being buzzed simultaneously by the carpenter bees that pollinate M. malabathricum , pollen from the purple ‘fertilization’ stamens is dramatically more likely to land on stigmas than pollen from the yellow ‘feeding’ stamens. Removal experiments showed that the yellow ‘feeding’ stamens also attracted pollinators from a distance. Flowers that had their anther pores plugged received fewer buzzing bouts per visit, indicating that bees assessed the amount of pollen received per bout. Surprisingly, there was no significant difference in pollen loads on stigmas of flowers that had their anthers plugged and stigmas of controls, demonstrating the efficiency of vector-assisted cross-pollination and the lack of vector-assisted self-pollination. 4. The unexpectedly precise placement of pollen grains even with buzz pollination, with a large proportion of the grains deposited out of the bees’ grooming reach, helps explain the evolutionary persistence of pollen as a reward in spite of the bees’ ability to assess the amount of pollen received during foraging bouts. Together, these results strongly support Darwin’s division-of-labour hypothesis.
Association of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) with Uric Acid among Adults with Elevated Community Exposure to PFOA

Background Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are compounds that do not occur in nature, have been widely used since World War II, and persist indefinitely in most environments. Median serum levels in the United States are 4 ng/mL for PFOA and 21 ng/mL for PFOS. PFOA has been associated with elevated uric acid in two studies of chemical workers. Uric acid is a risk factor for hypertension and possibly other cardiovascular outcomes. Methods We conducted a cross-sectional study of PFOA and PFOS and uric acid among 54,951 adult community residents in Ohio and West Virginia, who lived or worked in six water districts contaminated with PFOA from a chemical plant. Analyses were conducted by linear and logistic regression, adjusted for confounders. Results Both PFOA and PFOS were significantly associated with uric acid. An increase of 0.2–0.3 mg/dL uric acid was associated with an increase from the lowest to highest decile of either PFOA or PFOS. Hyperuricemia risk increased modestly with increasing PFOA; the odds ratios by quintile of PFOA were 1.00, 1.33 [95% confidence interval (CI), 1.24–1.43], 1.35 (95% CI, 1.26–1.45), 1.47 (95% CI, 1.37–1.58), and 1.47 (95% CI, 1.37–1.58; test for trend, p < 0.0001). We saw a less steep trend for PFOS. Inclusion of both correlated fluorocarbons in the model indicated PFOA was a more important predictor than was PFOS. Conclusion Higher serum levels of PFOA were associated with a higher prevalence of hyperuricemia, but the limitations of cross-sectional data and the possibility of noncausal mechanisms prohibit conclusions regarding causality.
Leadership and gender in higher education: a case study

Literature concerning leadership styles in HE provides no distinct view on whether style relates to gender. Transformational styles are regarded by some as particularly suited to times of change, and likely to be adopted by women; but others argue such styles are unsuited to HE. In a study of leadership within an institute of higher education undergoing change, transformational and transactional leadership behaviours were identified in all senior managers, male and female. However, when official communications were plotted over time, transformational attitudes were superseded by transactional. Women managers apparently identified more with male gender paradigms and displayed male-type leadership behaviours, whilst men showed female paradigm identification and female-type leadership. Additionally, managers indicated that past experience of ‘poor’ management and their subject training had greatly influenced their leadership approaches.
Imaging with terahertz waves.

We present what is to our knowledge the first imaging system based on optoelectronic terahertz time-domain spectroscopy. Terahertz time-domain waveforms are downconverted from the terahertz to the kilohertz frequency range, and the waveform for each pixel is frequency analyzed in real time with a digital signal processor to extract compositional information at that point. We demonstrate applications to package inspection and chemical content mapping in biological objects.
Marker-Assisted Breeding as Next-Generation Strategy for Genetic Improvement of Productivity and Quality: Can It Be Realized in Cotton?

The dawdling development in genetic improvement of cotton with conventional breeding program is chiefly due to lack of complete knowledge on and precise manipulation of fiber productivity and quality. Naturally available cotton continues to be a resource for the upcoming breeding program, and contemporary technologies to exploit the available natural variation are outlined in this paper for further improvement of fiber. Particularly emphasis is given to application, obstacles, and perspectives of marker-assisted breeding since it appears to be more promising in manipulating novel genes that are available in the cotton germplasm. Deployment of system quantitative genetics in marker-assisted breeding program would be essential to realize its role in cotton. At the same time, role of genetic engineering and in vitro mutagenesis cannot be ruled out in genetic improvement of cotton.
The Structure of Scientific Literatures II: Toward a Macro- and Microstructure for Science

Part I of this paperl described the first steps in mapping the scientific literature, using a new technique-co-citation-to measure the degree of similarity among documents. The work developed directly from an earlier paper2 which defined this measure, and explored its relationship to other citation measures for identifying relationships among documents. We now report the outcome of an attempt to create 'maps' of the scientific literature. The scales of these maps have been systematically manipulated so that they present, not only an overview of all highly-cited papers in natural science, but
Reducing overfitting of AdaBoost by clustering-based pruning of hard examples

In order to solve the problem of overfitting in AdaBoost, we propose a novel AdaBoost algorithm using K-means clustering. AdaBoost is known as an effective method for improving the performance of base classifiers both theoretically and empirically. However, previous studies have shown that AdaBoost is prone to overfitting in overlapped classes. In order to overcome the overfitting problem of AdaBoost, the proposed method uses K-means clustering to remove hard-to-learn samples that exist on overlapped region. Since the proposed method does not consider hard-to-learn samples, it suffers less from the overfitting problem compared to conventional AdaBoost. Both synthetic and real world data were tested to confirm the validity of the proposed method.
The PLAT Study: hemostatic function in relation to atherothrombotic ischemic events in vascular disease patients. Principal results. PLAT Study Group. Progetto Lombardo Atero-Trombosi (PLAT) Study Group.

The Progetto Lombardo Atero-Trombosi (PLAT) Study was a prospective, multicenter, multidisciplinary study of the association among hemostatic variables, conventional risk factors, and atherothrombotic events in four groups of patients with preexisting vascular ischemic disease (335 myocardial infarction survivors, 123 patients with stable angina pectoris, 160 with transient ischemic attacks, and 335 with peripheral vascular disease). In the myocardial infarction group, univariate analysis showed that atherothrombotic events were associated with high fibrinogen (p = 0.001), factor VIII:C (p less than 0.001), and von Willebrand factor antigen (vWF:Ag) (p = 0.004) levels and with low high density lipoprotein cholesterol (p = 0.043), factor VII (p = 0.019), and protein C (p = 0.044) levels; multivariate analysis produced associations with high fibrinogen and factor VIII:C levels and low protein C levels. By both univariate and multivariate analysis, events in the angina pectoris group were associated with high vWF:Ag (p = 0.026) and leukocyte (p = 0.033) levels and the presence of carotid arterial stenosis (p = 0.063); associations with high leukocyte (p = 0.037) and factor VIII:C (p = 0.186) levels, family history (p = 0.031), and diabetes (p = 0.061) were also found in the group with transient ischemic attacks. In those with peripheral vascular disease, events were associated with Fontaine stage greater than or equal to IIB (p = 0.024), high factor VIII:C levels (p = 0.073), and low protein C (p = 0.028), fibrinogen (p = 0.030), antithrombin III (p = 0.054), and factor VII (p = 0.057) levels by univariate analysis and with Fontaine stage and low fibrinogen levels by multivariate analysis. (ABSTRACT TRUNCATED AT 250 WORDS)
The impact of political scandals on political support: An experimental test of two theories

One of the most obvious trends in Western democracies, during the past decades, has been the decline of citizens’ political support (that is, the growth of negative attitudes toward political parties, politicians and democracy). One explanation for this trend is that the number of political scandals has increased. However, the impact of political scandals on political support is not clear. Whereas the dysfunctional theory assumes that political scandals in general have an unfavourable impact on the political system, functional theory claims that political scandals can have positive effects. Using data from an experiment, this article analyses which theory is superior. It finds support for the dysfunctional theory: support for politicians and political parties was significantly eroded after exposure to scandal coverage whereas trust in institutions as well as satisfaction with democracy were not affected. The article concludes that political scandals contribute to the decline of political support.
Evaluation of Brain Edema Formation Defined By MRI After LINAC-based Stereotactic Radiosurgery

Abstract Background Peri-lesional edema is a serious and well-known complication of stereotactic radiosurgery (SRS). Here we evaluated edema risk after SRS and assessed its formation and resolution dynamics. Patients and methods 107 patients underwent SRS for heterogeneous diagnoses: 34 (29%) with arteriovenous malformations, 38 (35%) with meningiomas, 16 (15%) with metastatic tumors, 16 (15%) with acoustic neuromas, 3 with (3%) cavernomas, and 2 (2%) each with anaplastic astrocytomas and anaplastic oligoastrocytomas. Edema area was delineated in MRI T2-FLAIR sequences 0, 6, 12, 18, 24, 30, and 38 months after treatment. Lesion location was defined as either above (n = 80) or below (n = 32) the “Frankfurt modified line” (FML). Results 17% of patients developed or had worsening post-treatment edema. Edema volume was maximal at 6 months (mean 7.2, SD 1.2) post radiosurgery. Post-SRS edema was 5.1 (1.06 – 24.53) times more likely in patients with lesions above the FML. There was no association between edema development and age, PTV size, number of beams, and diagnosis (p = 0.07). Conclusions Radiosurgery-associated edema develops within 6 months of treatment and decreases over time. Edema occurrence is strongly related to lesion location, and its presence is much more likely when the treated lesions are situated above the Frankfurt line.
Relationship of the oxidation state of the iron-sulfur cluster of aconitase to activity and substrate binding.

It is known that aconitase from mammalian mitochondria is only partially active as isolated but may be activated by incubation with iron, ascorbate, and a thiol, or with dithionite. It has been suggested that the added Fe in the activation mixture is essential for activation and that it is incorporated in the enzyme [Villafranca, J. J., & Mildvan, A. S. (1971) J. Biol. Chem. 246, 772-779; Gawron, O. , Waheed, A. , Glaid, A. J., & Jaklitsch, A. (1974) Biochem. J. 139, 709-714]. However, it is shown in this paper that, when the enzyme has a full complement of 3Fe and 3S, full activation is reached coulometrically, without iron or other chemical reducing agents. It is clear, therefore, that the role of activators is to reduce the iron--sulfur cluster of the enzyme. The appearance of catalytic activity on reduction of the cluster shows a pronounced lag, as does the decay of activity after reoxidizing the cluster. This suggests that catalytic activity requires a conformational change in the protein which is initiated by reduction of the cluster and that, following reoxidation, activity disappears only after the inactive conformation is assumed. Citrate and the competitive inhibitor trans-aconitate are bound to a comparable extent to the active and inactive forms, but only the active form can bind 1-hydroxy-2-nitro-1,3-propanedicarboxylic acid, a transition-state analogue. This is interpreted to show that in the inactive state aconitase cannot enter the conformation it assumes in the transition state during catalysis.
Power System Reliability Analysis with Distributed Generators

Reliability is a key aspect of power system design and planning. In this research we present a reliability analysis algorithm for large scale, radially operated (with respect to substation), reconfigurable, electrical distribution systems. The algorithm takes into account equipment power handling constraints and converges in a matter of seconds on systems containing thousands of components. Linked lists of segments are employed in obtaining the rapid convergence. A power flow calculation is used to check the power handling constraints. The application of distributed generators for electrical distribution systems is a new technology. The placement of distributed generation and its effects on reliability is investigated. Previous reliability calculations have been performed for static load models and inherently make the assumption that system reliability is independent of load. The study presented here evaluates improvement in reliability over a time varying load curve. Reliability indices for load points and the overall system have been developed. A new reliability index is proposed. The new index makes it easier to locate areas where reliability needs to be improved. The usefulness of this new index is demonstrated with numerical examples.