Miracle-dz/UniFAR-FTUs huggingface dataset:
Hypoxia stimulates vesicular ATP release from rat osteoblasts

Many neuronal and non‐neuronal cell types release ATP in a controlled manner. After release, extracellular ATP (or, following hydrolysis, ADP) acts on cells in a paracrine manner via P2 receptors. Extracellular nucleotides are now thought to play an important role in the regulation of bone cell function. ATP (and ADP), acting via the P2Y1 receptor, stimulate osteoclast formation and activity, whilst P2Y2 receptor stimulation by ATP (or UTP) inhibits bone mineralization by osteoblasts. We found that rat calvarial osteoblasts released ATP constitutively, in a differentiation‐dependent manner, with mature, bone‐forming osteoblasts releasing up to sevenfold more ATP than undifferentiated, proliferating cells. The inhibitors of vesicular exocytosis, monensin, and N‐ethylmaleimide (1–1,000 µM) inhibited basal ATP release by up to 99%. The presence of granular ATP‐filled vesicles within the osteoblast cytoplasm was demonstrated by quinacrine staining. Exposure to hypoxia (2% O2) for up to 3 min increased ATP release from osteoblasts up to 2.5‐fold without affecting cell viability. Peak concentrations of ATP released into culture medium were >1 µM, which equates with concentrations known to exert significant effects on osteoblast and osteoclast function. Monensin and N‐ethylmaleimide (100 µM) attenuated the hypoxia‐induced ATP release by up to 80%. Depletion of quinacrine‐stained vesicles was also apparent after hypoxic stimulation, indicating that ATP release had taken place. These data suggest that vesicular exocytosis is a key mediator of ATP release from osteoblasts, in biologically significant amounts. Moreover, increased extracellular ATP levels following acute exposure to low O2 could influence local purinergic signaling and affect the balance between bone formation and bone resorption. J. Cell. Physiol. 220: 155–162, 2009. © 2009 Wiley‐Liss, Inc.
Britain and the Labor Trade in the Southwest Pacific

Spend your time even for only few minutes to read a book. Reading a book will never reduce and waste your time to be useless. Reading, for some people become a need that is to do every day such as spending time for eating. Now, what about you? Do you like to read a book? Now, we will show you a new book enPDFd britain and the labor trade in the southwest pacific that can be a new way to explore the knowledge. When reading this book, you can get one thing to always remember in every reading time, even step by step.
Dye-sensitized solar cells: Sensitized with triple dyes in ultraviolet to near infrared

Co-sensitization of triple dyes for panchromatic absorption is rare in literature, here we present a dye sensitized solar cell (DSSCs) co-sensitized with molecular engineered organic butyloxyl chain induced Y1 dye, bodipy dye TP2A, and squaraine based dye SQ1. The co-sensitized TP2A+SQ1 showed efficiency of 5.60%. This co-sensitized triple dies shows a wide range of absorption spectrum from 300nm-800nm region under 1 sunlight illumination (100 mW/cm2) in DSSCs operation. By controlling the volumetric ratio a high photocurrent density (JSC) of 14.59 mAcm-2 and 0.703 fill factor were achieved. This yielded to an impressive efficiency of 6.21% for Y1+TP2A+SQ1 co-sensitized dyes, which is higher than that of each individual dyes. It was also observed that the efficiency of co-sensitized triple dyes is higher than co-sensitized of TP2A+SQ1 in solar cells.
International Conference on Knowledge Based and Intelligent Information and Engineering Systems , KES 2017 , 6-8 September 2017 , Marseille , France Curumim : A Serendipitous Recommender System based on Human Curiosity

Tourism is an important source of income of countries, since nowadays 10% of GDP corresponds to a direct, indirect or induced effect of tourism. In European countries like Spain, the activity reached numbers like 11% of GDP in 2016. Therefore, providing an efficient and personalised service for tourists has become an essential issue in the development of new technological resources. This work aims to build a better experience for the tourist through the fusion of three axes: human psychology, namely curiosity, technological innovation and social networks. This article describes CURUMIM system, which, from data available on social networks, predicts the level of curiosity of a user and then, tied to other measures, generates novel and serendipitous recommendations of touristic places around the world. In other words, the recommendations will be accurate and adapted to the level of curiosity of a given user on one hand and, on the other, they will positively surprise the users. c 2017 he uthors. Published by Elsevier B. i i ilit t ti l.
Efficient Search Algorithms in the Presence of Measurement Uncertainty

In this work, we study the problem of efficient resource selection in real-time distributed systems. Specifically, we study how a client in the presence of measurement uncertainty can rapidly select a resource (target) that exhibits good network connectivity. The problem has many applications, including peer selection in P2P systems, server/gateway selection in IP telephony, and overlay routing. A probing-based search strategy is complicated by the potentially large number of targets and the inherent uncertainty in measurement results due to, for instance, small measurement sample sizes and other forms of "noise. " We parameterize the problem based on the number of available targets, the number of "good" targets, and various network characteristics. We introduce a framework called spatial slow start (SSS) for searching the target space. SSS can be considered as a parameterized tree search with an interesting twist: apart from the target search space, the rate of probing per target is also manipulated at each step. A detailed simulation study provides insight on what SSS choices are significant under different network conditions. The simulation study also establishes that previously proposed techniques, namely, a random selection (RAND) algorithm that does not do any probing, and a "quick probe and select the best" (QPS) technique work well, but only in some situations. Based on these insights, we present an adaptive SSS algorithm that not only guides the search process according to its measurements of various system parameters, but also changes its search parameters in response to the quality of the measurements themselves. This new adaptive SSS algorithm performs as well as RAND and QPS in situations where RAND and QPS are efficient, and outperforms them in other cases.
Structure Sensitive Hashing With Adaptive Product Quantization

Hashing has been proved as an attractive solution to approximate nearest neighbor search, owing to its theoretical guarantee and computational efficiency. Though most of prior hashing algorithms can achieve low memory and computation consumption by pursuing compact hash codes, however, they are still far beyond the capability of learning discriminative hash functions from the data with complex inherent structure among them. To address this issue, in this paper, we propose a structure sensitive hashing based on cluster prototypes, which explicitly exploits both global and local structures. An alternating optimization algorithm, respectively, minimizing the quantization loss and spectral embedding loss, is presented to simultaneously discover the cluster prototypes for each hash function, and optimally assign unique binary codes to them satisfying the affinity alignment between them. For hash codes of a desired length, an adaptive bit assignment is further appended to the product quantization of the subspaces, approximating the Hamming distances and meanwhile balancing the variance among hash functions. Experimental results on four large-scale benchmarks CIFAR-10, NUS-WIDE, SIFT1M, and GIST1M demonstrate that our approach significantly outperforms state-of-the-art hashing methods in terms of semantic and metric neighbor search.
Poster: Energy Efficient Navigation Systems

The sudden growth in the smart-phone industry in recent years has caught the localization technology quite unprepared, with GPS coming out as a trivial solution. Using GPS, although quite effective, results in high energy consumption. This makes way for the several inertial sensors present in smart-phones like accelerometer, gyroscope, compass, etc. There are number of works like UnLoc[3] which use these inertial sensors for pedestrian localization. Looking into outdoor vehicular localization, Dejavu[1] is one of the good solutions. In our research problems we plan to make use of inertial sensors to develop energy efficient navigation systems and the underlying infrastructure required for the same. Here, we present a novel generalized energy-efficient outdoor navigation scheme - UrbanEye[2]
Scalable Parallel EM Algorithms for Latent Dirichlet Allocation in Multi-Core Systems

Latent Dirichlet allocation (LDA) is a widely-used probabilistic topic modeling tool for content analysis such as web mining. To handle web-scale content analysis on just a single PC, we propose multi-core parallel expectation-maximization (PEM) algorithms to infer and estimate LDA parameters in shared memory systems. By avoiding memory access conflicts, reducing the locking time among multiple threads and residual-based dynamic scheduling, we show that PEM algorithms are more scalable and accurate than the current state-of-the-art parallel LDA algorithms on a commodity PC. This parallel LDA toolbox is made publicly available as open source software at mloss.org.
Selective and efficient electrochemical biosensing of ultrathin molybdenum disulfide sheets

Atomically thin molybdenum disulfide (MoS2) sheets were synthesized and isolated via solvent-assisted chemical exfoliation. The charge-dependent electrochemical activities of these MoS2 sheets were studied using positively charged hexamine ruthenium (III) chloride and negatively charged ferricyanide/ferrocyanide redox probes. Ultrathin MoS2 sheet-based electrodes were employed for the electrochemical detection of an important neurotransmitter, namely dopamine (DA), in the presence of ascorbic acid (AA). MoS2 electrodes were identified as being capable of distinguishing the coexistence of the DA and the AA with an excellent stability. Moreover, the enzymatic detection of the glucose was studied by immobilizing glucose oxidase on the MoS2. This study opens enzymatic and non-enzymatic electrochemical biosensing applications of atomic MoS2 sheets, which will supplement their established electronic applications.
The Effects of Dry Period and Various Lactation Stages on Blood Na + and K + Concentrations

SUMMARY This study was carried out on eighty Holstein dairy cows of four years of age and in their second lactation from Bursa region of Turkey. Twenty of them were in dry period and the rest were in lactation period. The days 4851st, 147-161st and 180. and over were accepted as first, second and third period, respectively. Blood samples taken from animals into heparinized tubes were analysed for erythrocyte sodium, erythrocyte potassium, whole blood sodium, whole blood potassium and haematocrit. There was no statistically significant effect of lactation periods on examined parameters except haematocrit.
Modulation of the transport of a lysosomal enzyme by PDGF

The major excreted protein (MEP) of transformed mouse fibroblasts is the lysosomal protease, cathepsin L. MEP is also secreted by untransformed mouse cells in response to growth factors and tumor promoters, and is thought to play a role in cell growth and transformation. To determine the relationship between MEP synthesis and MEP secretion, we have examined these events in PDGF-treated NIH 3T3 cells. PDGF enhanced MEP synthesis and caused the diversion of MEP from the lysosomal delivery pathway to a secretory pathway. These two effects were found to be regulated independently at various times after growth factor addition. Short PDGF treatments (0.5 or 1 h) resulted in quantitative secretion of MEP although synthesis was near the control level. High levels of both synthesis and secretion occurred between 2 and 14 h of PDGF treatment. Between 18 and 30 h, the amount of secreted MEP returned to the low control level even though synthesis remained elevated. The secretion was specific for MEP; other lysosomal enzymes were not found in the media from PDGF-treated cells. PDGF-induced secretion of MEP was inhibited 84% by cycloheximide, suggesting that protein synthesis is required to elicit this effect. PDGF also caused a time-dependent increase in mannose 6-phosphate (Man-6-P) receptor- mediated endocytosis. These data support a model in which PDGF alters the distribution of Man-6-P receptors such that the Golgi concentration of receptors becomes limiting, thereby causing the selective secretion of the low affinity ligand, MEP.
Potential Role of Placebo-Effect in the Anti-Epileptic Influence of Meditation in Patients with Epilepsy

Meditation has remained a widely practiced technique since long and the spectrum of health disorders in which it is claimed to exercise significant remedial efficacy has widened in recent past. Meditation has also been considered a safe and harmless mental practice for neurological disorders especially epilepsy for a long period of time. However, in recent times, its role in epilepsy has emerged as a topic of debate resulting in interest and exploration of the mechanisms involved in its epileptogenic versus anti-epileptic influence. It is recognized that several factors contribute to the remedial efficacy of a medical intervention, especially alternative forms of medical therapies, the role of which may be direct or indirect. Placebo-effect is one such factor that has been known for a long period of time to contribute to remedial efficacy of medical therapies, the exact mechanism of which also needs to be elucidated. This brief paper is intended to explore the role of placebo-effect in the anti-epileptic influence of meditation.
Binary Mask Estimation for Improved Speech Intelligibility in Reverberant Environments

A blind (non-ideal) time-frequency (T-F) masking technique is proposed for suppressing reverberation. A binary mask is estimated at each T-F unit by extracting a single variance-based feature from the reverberant signal and comparing its value against an adaptive threshold. The performance of the estimated binary mask is evaluated using intelligibility listening tests with hearing impaired listeners in four moderate to highly reverberant conditions. Results indicated that the proposed T-F masking technique yielded significant improvements in intelligibility even in highly reverberant conditions (T60 = 1.0 s). This improvement was attributed to the recovery of the vowel/consonant boundaries which are severely smeared in reverberation.
The Meaning of Chronic Marijuana Use among Adults: A Psychosocial Perspective

Research on marijuana smoking among adults has raised questions about whether such behavior is essentially maladaptive. Drawing from their study of the role of marijuana in the psychosocial adaptation of long-term, heavy adult users, the authors explore the meaning this behavior appears to have for such individuals. On the basis of questionnaire results obtained from 150 chronic marijuana-smoking adults, use of the drug was not found to be linked with maladaptive functioning in any consistent behavioral sense. Intensive interviews with a smaller number of subjects revealed a quite different picture, however, pointing to a relationship between heavy marijuana use and significant adaptive difficulties in the areas of work and personal relationships. While suggesting the need to use psychodynamic, as well as social variables, in defining marijuana abuse, the authors caution against concluding a causal linkage between the drug behavior and users' difficulties in psychosocial functioning.
Archiving as a service: a model for the provision of shared archiving services using cloud computing

In this paper, we define some of the characteristics of archiving in a cloud computing environment. Based on these, we describe a model for a cloud archiving system using concepts and information types from the OAIS reference model. The proposed model allows the sharing of functionality and information objects by making these available as services to above layers. The model covers the entire document lifecycle, making archive functionality such as preservation planning possible at an early stage in the document lifecycle, helping to simplify records transfer. Finally, we use our model in a case study, using the records transfer process from Japanese government agencies to the National Archives of Japan as an example.
Predictors of Treatment Seeking Intention among People with Cough in East Wollega, Ethiopia Based on the Theory of Planned Behavior: A Community Based Cross-Sectional Study

Background Early treatment seeking for cough is crucial in the prevention and control of Tuberculosis. This study was intended to assess treatment seeking intention of people with cough of more than two weeks, and to identify its predictors. Methods A community based cross-sectional study was conducted among 763 individuals with cough of more than two weeks in East Wollega Zone from March 10 to April 16, 2011. Study participants were selected from eighteen villages by cluster sampling method. Data collection instruments were developed according to the standard guideline of the theory of planned behavior. The data were analyzed with SPSS 16.0. Multiple linear regression was used to identify predictors. Results Mean score of intention was found to be 12.6 (SD=2.8) (range of possible score=3–15). Knowledge (β=0.14, 95%CI: 0.07-0.2), direct attitude (β=0.31, 95%CI: 0.25–0.35), belief-based attitude (β=0.03, 95%CI: 0.02–0.06) and perceived subjective norm (β=0.22, 95%CI: 0.13–0.31) positively predicted treatment seeking intention. However, perceived behavioral control and control belief were not significantly associated with treatment seeking intention (p>0.05). Being smoker (β=−0.97, 95%CI:−1.65 (−0.37)) and higher family income (β=−0.06, 95%CI:−0.07-(−0.01) were significantly associated with lower treatment seeking intention. Conclusion TPB significantly predicted treatment seeking intention among the study participants. Attitude and silent beliefs held by the respondents play an important role and should be given emphasize in prevention and control of Tuberculosis.
Energy Pipeline Networks and Trust: The European Union and Russia in Comparative Perspective

Energy pipeline networks tie nations together in webs of interdependence that are mutually beneficial but which also make countries vulnerable. This article explores the relationship between political trust and energy pipelines connecting Russia and the European Union (EU). It seeks to explain low levels of trust in the EU–Russia energy relationship, varying levels of energy cooperation and trust within the EU toward Russia, and whether the EU–Russia energy relationship is representative of vulnerabilities shared by producers and consumers in other contexts. Rationalist approaches that focus on interests and reciprocity are incomplete and should be supplemented by a concept of trust based on normative factors. This article finds that political disputes with transit and consumer states, competing norms, and the legacy of mistrust from the Cold War (especially among certain East European countries) combined to form a uniquely toxic relationship.
Inhibition of the Bcl-xL deamidation pathway in myeloproliferative disorders.

BACKGROUND The myeloproliferative disorders are clonal disorders with frequent somatic gain-of-function alterations affecting tyrosine kinases. In these diseases, there is an increase in DNA damage and a risk of progression to acute leukemia. The molecular mechanisms in myeloproliferative disorders that prevent apoptosis induced by damaged DNA are obscure. METHODS We searched for abnormalities of the proapoptotic Bcl-x(L) deamidation pathway in primary cells from patients with chronic myeloid leukemia (CML) or polycythemia vera, myeloproliferative disorders associated with the BCR-ABL fusion kinase and the Janus tyrosine kinase 2 (JAK2) V617F mutation, respectively. RESULTS The Bcl-x(L) deamidation pathway was inhibited in myeloid cells, but not T cells, in patients with CML or polycythemia vera. DNA damage did not increase levels of the amiloride-sensitive sodium-hydrogen exchanger isoform 1 (NHE-1), intracellular pH, Bcl-x(L) deamidation, and apoptosis. Inhibition of the pathway was reversed by enforced alkalinization or overexpression of NHE-1, leading to a restoration of apoptosis. In patients with CML, the pathway was blocked in CD34+ progenitor cells and mature myeloid cells. Imatinib or JAK2 inhibitors reversed inhibition of the pathway in cells from patients with CML and polycythemia vera, respectively, but not in cells from a patient with resistance to imatinib because of a mutation in the BCR-ABL kinase domain. CONCLUSIONS BCR-ABL and mutant JAK2 inhibit the Bcl-x(L) deamidation pathway and the apoptotic response to DNA damage in primary cells from patients with CML or polycythemia vera.
Population attributable risks of esophageal and gastric cancers.

BACKGROUND Several risk factors have been identified for esophageal adenocarcinoma, gastric cardia adenocarcinoma, esophageal squamous cell carcinoma, and noncardia gastric adenocarcinoma, but no study has comprehensively examined their contributions to the cancer burden in the general population. Herein, we estimate the population attributable risks (PARs) for various risk factors observed in a multicenter population-based case-control study. METHODS We calculated PARs by using 293 patients with esophageal adenocarcinoma, 261 with gastric cardia adenocarcinoma, 221 with esophageal squamous cell carcinoma, 368 with noncardia gastric adenocarcinoma, and 695 control subjects. We included smoking for all four tumor types and Helicobacter pylori infection for noncardia gastric adenocarcinoma as established causal risk factors as well as several other factors for which causality is under evaluation. RESULTS Ever smoking, body mass index above the lowest quartile, history of gastroesophageal reflux, and low fruit and vegetable consumption accounted for 39.7% (95% confidence interval [CI] = 25.6% to 55.8%), 41.1% (95% CI = 23.8% to 60.9%), 29.7% (95% CI = 19.5% to 42.3%), and 15.3% (95% CI = 5.8% to 34.6%) of esophageal adenocarcinomas, respectively, with a combined PAR of 78.7% (95% CI = 66.5% to 87.3%). Ever smoking and body mass index above the lowest quartile were responsible for 45.2% (95% CI = 31.3% to 59.9%) and 19.2% (95% CI = 4.9% to 52.0%) of gastric cardia adenocarcinomas, respectively, with a combined PAR of 56.2% (95% CI = 38.1% to 72.8%). Ever smoking, alcohol consumption, and low fruit and vegetable consumption accounted for 56.9% (95% CI = 36.6% to 75.1%), 72.4% (95% CI = 53.3% to 85.8%), and 28.7% (95% CI = 11.1% to 56.5%) of esophageal squamous cell carcinomas, respectively, with a combined PAR of 89.4% (95% CI = 79.1% to 95.0%). Ever smoking, history of gastric ulcers, nitrite intake above the lowest quartile, and H. pylori infection were responsible for 18.3% (95% CI = 6.5% to 41.8%), 9.7% (95% CI = 5.4% to 16.8%), 40.7% (95% CI = 23.4% to 60.7%), and 10.4% (95% CI = 0.3% to 79.6%) of noncardia gastric adenocarcinomas, respectively, with a combined PAR of 59.0% (95% CI = 16.2% to 91.4%). CONCLUSION In this population, a few known risk factors account for a majority of esophageal and gastric cancers. These results suggest that the incidence of these cancers may be decreased by reducing the prevalence of smoking, gastroesophageal reflux, and being overweight and by increasing the consumption of fruits and vegetables.