Miracle-dz/UniFAR-FTUs huggingface dataset:
Differences in executive functioning between violent and non-violent offenders

Background A growing body of neuropsychological and neurobiological research shows a relationship between functioning of the prefrontal cortex and criminal and violent behaviour. The prefrontal cortex is crucial for executive functions such as inhibition, attention, working memory, set-shifting and planning. A deficit in these functions – a prefrontal deficit – may result in antisocial, impulsive or even aggressive behaviour. While several meta-analyses show large effect sizes for the relationship between a prefrontal deficit, executive dysfunction and criminality, there are few studies investigating differences in executive functions between violent and non-violent offenders. Considering the relevance of identifying risk factors for violent offending, the current study explores whether a distinction between violent and non-violent offenders can be made using an extensive neuropsychological test battery. Method Male remand prisoners (N = 130) in Penitentiary Institution Amsterdam Over-Amstel were administered an extensive neuropsychological test battery (Cambridge Automated Neuropsychological Test Battery; CANTAB) measuring response inhibition, planning, attention, set-shifting, working memory and impulsivity/reward sensitivity. Results Violent offenders performed significantly worse on the stop-signal task (partial correlation r = 0.205, p = 0.024), a task measuring response inhibition. No further differences were found between violent and non-violent offenders. Explorative analyses revealed a significant relationship between recidivism and planning (partial correlation r = −0.209, p = 0.016). Conclusion Violent offenders show worse response inhibition compared to non-violent offenders, suggesting a more pronounced prefrontal deficit in violent offenders than in non-violent offenders.
Reconsidering a Lower Level of Follicle-Stimulating Hormone as Abnormal in Sub-Fertile Males of Pakistan.

OBJECTIVE To assess the association between Follicle-Stimulating Hormone (FSH) and semen parameters in order to evaluate whether the current laboratory reference for abnormal FSH levels should be readjusted. STUDY DESIGN Observational, cross-sectional study. PLACE AND DURATION OF STUDY Infertility Clinic of Gynecology Unit 1, Civil Hospital, Karachi, from May 2015 to April 2016. METHODOLOGY The study included 100 sub-fertile males inducted from the clinic. Those above 45 years of age, with hypo gonadotrophic hypogonadism, and those on anabolic steroids were excluded. After history and examination, semen parameters and FSH levels were tested. Abnormal semen values were based on WHO 1999 criteria. Data was analyzed by SPSS 17 and mean, frequencies and percentages were calculated. Chi-square test was applied to check association between variables. RESULTS The FSH levels had a significant association with abnormal semen sperm concentration, motility and morphology but not with semen volume (p=0.246). The mean FSH level was 5.8 ±1.80 IU/Lwith two-thirds of individuals having value >4.5 IU/L. Frequency of semen abnormalities increased as the level of FSH increased. CONCLUSION There is significantly an increased possibility of abnormal semen characteristics at FSH levels >4.5, so the current reference level should be lowered down and adjusted again.
Chief physicians' attitudes towards early warning score systems in Switzerland: Results of a cross‐sectional survey

RATIONALE, AIMS AND OBJECTIVES Early warning score systems (EWS-S) have been shown to be valuable tools to recognize otherwise unnoticed clinical deterioration (CDET) of patients. They have been associated with fewer unplanned transfers to the intensive care unit (UTICU) and lower in-hospital mortality. Little is known about their current usage in Switzerland and about the attitudes towards such tools among chief physicians. We aimed to assess the use of EWS-S in Switzerland and the attitudes of chief physicians towards EWS-S depending on previously experienced CDET followed by UTICU, reanimation, or death. METHODS Chief physicians of medical and surgical departments from all acute care hospitals in Switzerland were asked to participate within a project that aims to develop recommendations for the use of EWS-S in Switzerland (n = 118). The explorative study assessed perceived CDET, which led to UTICU, reanimation, or death of a patient, the knowledge and usage about different EWS-S and attitudes towards EWS-S in a written questionnaire. Means and percentages were used, and differences were assessed with independent t tests, chi-square, or Fisher exact test, as appropriate. RESULTS Adverse events based on CDET were reported frequently, and awareness among chief physicians was high. Less than half of the chief physicians knew tools that systematically assess CDET with one-fifth of responders reporting using tools at their department. Previous experiences of UTICU, reanimation, or death after due to CDET were associated with more positive attitudes towards EWS-S. CONCLUSIONS Adverse events based on CDET of patients are frequent and the awareness of this problem is high among chief physicians. Positive attitudes were more common with previous experiences of adverse events due to CDET. Our results strengthen the argumentation that the recommendation and future implementation of EWS-S in Switzerland would be meaningful.
Tissue distribution of quercetin in pigs after long-term dietary supplementation.

Although the flavonol quercetin is intensively investigated, our knowledge about its bioavailability and possible target organs is far from being complete. The aim of this study was to check the potential of quercetin to accumulate in various tissues after long-term dietary treatment compared with a single treatment with flavonol. Pigs ingested either a single dose of quercetin aglycone (25 mg/kg body weight; Expt. 1) or received the flavonol twice a day at the same dose mixed into their regular meals (i.e 50 mg.kg(-1). d(-1)) for 4 wk (Expt. 2). In both experiments, we took plasma and tissue samples 90 min after the final meal and analyzed them using HPLC. Additionally, the specific activity of the enzyme beta-glucuronidase was measured in selected tissues. Higher flavonol concentrations than in plasma were found in only the liver (Expt. 1) or the intestinal wall and kidneys (Expt. 2). All tissues except blood plasma contained a variable amount of deconjugated quercetin in the range of 30-100% of total flavonols. However, the specific beta-glucuronidase activity was not correlated with the proportions of deconjugated flavonols in the various tissues. Long-term dietary intake of the flavonol did not lead to a greater accumulation in any tissue compared with the single treatment. Flavonol concentrations only exceeded the plasma concentration within organs involved in its metabolism and excretion, including liver, small intestine, and kidneys.
Comparison of Hamstring and Patellar Tendon Grafts

This study assessed the tensile properties of hamstring and patellar tendon anterior cruciate ligament reconstructions in older cadaveric knees (age range, 48 to 79 years). Mechanical testing to failure was conducted by translating the tibia anteriorly at 1 mm/sec with the knee in 20° of flexion. The strongest gracilis-semitendinosus graft fixation technique (103% of intact anterior cruciate ligament) had the tendons doubled and secured with soft tissue washers (P 0.05). Both types of grafts failed most often on the tibial side. With appropriate fixation, both grafts approximated the intact anterior cruciate ligament in strength, but only patellar tendon grafts secured with interference screws were comparable in stiffness.
Power Load Event Detection and Classification Based on Edge Symbol Analysis and Support Vector Machine

Energy signature analysis of power appliance is the core of nonintrusive load monitoring (NILM) where the detailed data of the appliances used in houses are obtained by analyzing changes in the voltage and current. This paper focuses on developing an automatic power load event detection and appliance classification based on machine learning. In power load event detection, the paper presents a new transient detection algorithm. By turn-on and turn-off transient waveforms analysis, it can accurately detect the edge point when a device is switched on or switched off. The proposed load classification technique can identify different power appliances with improved recognition accuracy and computational speed. The load classification method is composed of two processes including frequency feature analysis and support vector machine. The experimental results indicated that the incorporation of the new edge detection and turn-on and turn-off transient signature analysis into NILM revealed more information than traditional NILM methods. The load classification method has achieved more than ninety percent recognition rate.
A Reproducing Kernel Hilbert Space Approach to Functional Linear Regression

We study in this paper a smoothness regularization method for functional linear regression and provide a unified treatment for both the prediction and estimation problems. By developing a tool on simultaneous diagonalization of two positive definite kernels, we obtain shaper results on the minimax rates of convergence and show that smoothness regularized estimators achieve the optimal rates of convergence for both prediction and estimation under conditions weaker than those for the functional principal components based methods developed in the literature. Despite the generality of the method of regularization, we show that the procedure is easily implementable. Numerical results are obtained to illustrate the merits of the method and to demonstrate the theoretical developments.
Protein intake: effects on bone mineral density and the rate of bone loss in elderly women.

BACKGROUND The role of dietary protein in bone metabolism is controversial. OBJECTIVE We investigated the associations of dietary protein intake with baseline bone mineral density (BMD) and the rate of bone loss over 3 y in postmenopausal elderly women. DESIGN Women aged 65-77 y (n = 489) were enrolled in an osteoporosis intervention trial. We studied the associations of protein intake as a percentage of energy with baseline BMD and the rate of bone loss in 96 women in the placebo group (n = 96). We also examined the effect of the interaction of dietary calcium intake with protein intake on BMD. RESULTS In the cross-sectional study, a higher intake of protein was associated with higher BMD. BMD was significantly higher (P < 0.05) in the spine (7%), midradius (6%), and total body (5%) in subjects in the highest quartile of protein intake than in those in the lower 2 quartiles. This positive association was seen in women with calcium intakes > 408 mg/d. There was no significant effect of protein intake on hip BMD. In the longitudinal study of the placebo group, there was no association between protein intake and the rate of bone loss. CONCLUSIONS The highest quartile of protein intake (: 72 g/d) was associated with higher BMD in elderly women at baseline only when the calcium intake exceeded 408 mg/d. In the longitudinal study, no association was seen between protein intake and the rate of bone loss, perhaps because the sample size was too small or the follow-up period of 3 y was not long enough to detect changes.
Association between MCP-1 -2518A/G Polymorphism and Cancer Risk: Evidence from 19 Case-Control Studies

Background Single nucleotide polymorphisms (SNPs) may affect the development of diseases. The -2518A/G polymorphism in the regulatory region of the monocyte chemo-attractant protein-1 (MCP-1) gene has been reported to be associated with cancer risk. However, the results of previous studies were inconsistent. Therefore, we performed a meta-analysis to obtain a more precise estimation of the relationship between the -2518A/G polymorphism and cancer risk. Methodology/Principal Findings We performed a meta-analysis, including 4,162 cases and 5,173 controls, to evaluate the strength of the association between the −2518A/G polymorphism and cancer risk. Odds ratio (OR) and 95% confidence intervals (95% CIs) were used to assess the strength of association. Overall, the results indicated that the −2518A/G polymorphism was not statistically associated with cancer risk. However, sub-group analysis revealed that individuals with GG genotypes showed an increased risk of cancer in digestive system compared with carriers of the A allele (GG vs. AA: OR = 1.43, 95%CI = 1.05–1.96, Pheterogeneity = 0.08; GG vs. AG/AA: OR = 1.29, 95%CI = 1.02–1.64, Pheterogeneity = 0.14). In addition, the increased risk of GG genotype was also observed in Caucasians (GG vs. AG/AA: OR = 1.81, 95%CI = 1.10–2.96, Pheterogeneity = 0.02). Conclusion This meta-analysis suggests that the MCP-1 −2518A/G polymorphism may have some relation to digestive system cancer susceptibility or cancer development in Caucasian. Large-scale and well-designed case-control studies are needed to validate the findings.
Television watching increases motivated responding for food and energy intake in children.

BACKGROUND Sedentary activities, such as watching television, may disrupt habituation to food cues, thereby increasing motivation to eat and energy intake. OBJECTIVE These experiments were designed to examine the effect of television watching on habituation of ingestive behavior in children. DESIGN In experiment 1, all children worked for access to cheeseburgers in trials 1-7 (habituating stimulus). In trials 8-10, children in the control group continued to work for cheeseburgers without any dishabituating stimuli, whereas children in the other groups received either a novel food (French fries) or television as dishabituating stimuli. Responding for food and amount of food eaten were measured. In experiment 2, all children had access to 1000 kcal of a preferred snack food. One group watched a continuous television show, and the control groups either watched no television or watched a repeated segment of a television show, which controls for the television stimulus but requires reduced allocation of attention. RESULTS In experiment 1, both the novel food and the television watching groups reinstated responding for food (P = 0.009) and increased the amount of energy earned (P = 0.018) above the level of the control subjects. In experiment 2, the continuous television group spent more time eating (P < 0.0001) and consumed more energy than the no television and the repeated segment groups (P = 0.007). CONCLUSION These experiments show that television watching can dishabituate eating or disrupt the development of habituation, which may provide a mechanism for increased energy intake associated with watching television.
Explorer Probing the Modulation of Acute Ethanol Intoxication by Pharmacological Manipulation of the NMDAR Glycine Co-Agonist

BACKGROUND—Stimulating the glycineB binding site on the N-methyl-D-aspartate receptor (NMDAR) has been proposed as a novel mechanism for modulating behavioral effects of ethanol (EtOH) that are mediated via the NMDAR, including acute intoxication. Here, we pharmacologically interrogated this hypothesis in mice. METHODS—Effects of systemic injection of the glycineB agonist, D-serine, the GlyT-1 glycine transporter inhibitor, ALX-5407, and the glycineB antagonist, L-701,324, were tested for effects on EtOH-induced ataxia, hypothermia, loss of righting reflex duration (LORR) in C57BL/6J (B6) and 129S1/SvImJ (S1) inbred mice. Effects of the glycineB partial agonist, D-cycloserine, the GlyT-1 inhibitor, NFPS, and the glycineB antagonist, DCKA, on EtOH-induced LORR duration were also tested. Interaction effects on EtOH-induced LORR duration were examined via combined treatment with D-serine and ALX-5407, D-serine and MK-801, D-serine and L-701,324, as well as L-701,324 and ALX-5407, in B6 mice, as D-serine in GluN2A and PSD-95 KO mice. The effect of dietary depletion of Magnesium (Mg), an element which interacts the glycineB site, was also tested. RESULTS—Neither D-serine, D-cycloserine, ALX-5407, nor NFPS significantly affected EtOH intoxication on any of the measures or strains studied. L-701,324, but not DCKA, dosedependently potentiated the ataxia-inducing effects of EtOH and increased EtOH-induced (but not pentobarbital-induced) LORR duration. D-serine did not have interactive effects on EtOH-induced LORR duration when combined with ALX-5407. The EtOH-potentiating effects of L-701,324, but not MK-801, on LORR duration were prevented by D-serine, but not ALX-5407. Mg depletion potentiated LORR duration in B6 mice and was lethal in a large proportion of S1 mice. CONCLUSIONS—GlycineB site activation failed to produce the hypothesized reduction in EtOH intoxication across a range of measures and genetic strains, but blockade of the glycineB site potentiated EtOH intoxication. These data suggest endogenous activity at the glycineB opposes Corresponding author: Andrew Holmes, 5625 Fishers Lane Rm 2N09, Rockville, MD 20852-9411, USA, Andrew.Holmes@nih.gov, Telephone: 301-402-3519, Fax: 301-480-1952. *Joint first authorship NIH Public Access Author Manuscript Alcohol Clin Exp Res. Author manuscript; available in PMC 2014 February 01. Published in final edited form as: Alcohol Clin Exp Res. 2013 February ; 37(2): 223–233. doi:10.1111/j.1530-0277.2012. 01922.x. N IH PA Athor M anscript N IH PA Athor M anscript N IH PA Athor M anscript EtOH intoxication, but it may be difficult to pharmacologically augment this action, at least in non-dependent subjects, perhaps due to physiological saturation of the glycineB site.
Auditing Rational Adversaries to Provably Manage Risks

Abstract : Audits to detect policy violations coupled with punishments are essential to manage risks stemming from inappropriate information use by authorized insiders in organizations that handle large volumes of personal information (e.g., in healthcare, finance, Web services sectors). Our main result is an audit mechanism that effectively manages organizational risks by balancing the cost of audit and punishment against the expected loss from policy violations. We model the interaction between an organization (defender) and an employee (adversary) as a suitable repeated game. We assume that the defender is fully rational and the adversary is near-rational (i.e., acts rationally with high probability and in a byzantine manner otherwise). The mechanism prescribes a strategy for the defender that when paired with the adversary's best response to it yields an asymmetric subgame perfect equilibrium. This equilibrium concept, which we define, implies that the defender's strategy is approximately optimal (she might only gain a small bounded amount of utility by deviating) while the adversary does not gain at all from deviating from her best response strategy. We provide evidence that a number of parameters in the game model can be estimated from prior empirical studies, suggest specific studies that can help estimate other parameters, and design a learning algorithm that the defender can use to provably learn the adversary's private incentives. Finally, we use our model to predict observed practices in industry (e.g., differences in punishment rates of doctors and nurses for the same violation) and the effectiveness of policy interventions (e.g., data breach notification laws and government audits) in encouraging organizations to conduct more thorough audits.
Delayed Magnetic Resonance Imaging in Patients With Cervical Spinal Cord Injury Without Radiographic Abnormality

Study Design. A prospective imaging study to develop diagnostic criteria. Objective. The aim of this study was to investigate image findings on delayed magnetic resonance imaging (MRI) after the acute phase of spinal cord injury without radiographic abnormality (SCIWORA) and their relationship with symptom severity. Summary of Background Data. MRI is used to diagnose acute neurological injury, with increased signal intensity (ISI) and prevertebral hyperintensity (PVH) often seen in patients with SCIWORA; however, changes after the acute phase are unclear. Methods. We included 68 patients diagnosed with SCIWORA within 48 hours of injury. We then compared their acute (within 2 days) and delayed (after 2 weeks) MRI images. ISI grade (0–3) and ISI and PVH ranges (relative to the C3 vertebral height) were measured. Neurological status at admission and 2 weeks after injury was assessed by the Japanese Orthopaedic Association scoring system for cervical myelopathy (JOA score) and the American Spinal Injury Association impairment scale. Results. For acute MRI, the rates of grade 0, 1, and 2 ISI were 4, 54, and 10 patients, respectively. For delayed MRI, the rates of grade 0, 1, and 2 ISI changed to 3, 31, and 34 patients, respectively. ISI ranges reduced in delayed MRI, but there was no significance. PVH ranges were 3.0 ± 1.7 in acute MRI, and reduced to 1.3 ± 0.9 with significant difference (P < 0.001). There were significant negative correlations with the JOA score for ISI grades on delayed MRI only (r = −0.49). However, there were significant negative correlations with the JOA score for the PVH range on both the acute (r = −0.55) and delayed (r = −0.46) MRI. Conclusion. When comparing acute and delayed MRI, there were significant differences in ISI and PVH findings. Delayed MRI also reflected the clinical symptom severity, giving useful information about the state of the spinal cord. Level of Evidence: 3
Jugular Venous Reflux Is Associated with Perihematomal Edema after Intracerebral Hemorrhage

The purpose of this study was to determine whether jugular venous reflux (JVR) is associated with perihematomal edema (PHE) in individuals with intracerebral hemorrhage (ICH). Patients with spontaneous supratentorial ICH within 72 h of symptom onset were enrolled. Baseline brain computed tomography (CT) scan was performed, with a follow-up CT examination at 12 ± 3 days after onset. Jugular venous color Doppler ultrasound was performed at 12 ± 3 days after onset to examine the JVR status. A total of 65 patients with ICH were enrolled. In logistic regression analysis, absolute PHE volume was significantly associated with JVR (OR, 5.46; 95% CI, 1.04–28.63; p = 0.044) and baseline hematoma volume (OR, 1.14; 95% CI, 1.03–1.26; p = 0.009) within 72 h of onset. It was also correlated with JVR (OR, 15.32; 95% CI, 2.52–92.99; p = 0.003) and baseline hematoma volume (OR, 1.14; 95% CI, 1.04–1.24; p = 0.006) at 12 ± 3 days after onset. In a similar manner, relative PHE volume was significantly associated with JVR (OR, 14.85; 95% CI, 3.28–67.17; p < 0.001) within 72 h of onset and at 12 ± 3 days after onset (OR, 5.87; 95% CI, 1.94–17.77; p = 0.002). JVR is associated with both absolute and relative PHE volumes after ICH.
Profile of reslizumab in eosinophilic disease and its potential in the treatment of poorly controlled eosinophilic asthma

Eosinophils are important proinflammatory cells that make a major contribution to the inflammation seen in allergic diseases including asthma. Interleukin-5 is central to eosinophil maturation, release from the bone marrow, and subsequent accumulation, activation, and persistence in the tissues. Reslizumab (Cinquil™) is a humanized monoclonal antibody with potent interleukin-5 neutralizing effects, which represents a potential treatment for poorly controlled eosinophilic asthma. This review will consider the current status of the clinical development of reslizumab for asthma and in other inflammatory diseases with a marked eosinophilic component.