Miracle-dz/UniFAR-FTUs huggingface dataset:
Problems of anticoagulation within a palliative care setting: an audit of hospice patients taking warfarin

Patients with cancer have an increased risk of venous thromboembolism (VTE) compared with a healthy population. The risk increases as cancer progresses and this is reflected in the number of hospice inpatients with VTE. These patients also have an increased risk of bleeding due to tumour site, complications of treatment, progressive liver involvement and concurrent medication such as nonsteroidal anti-inflammatory agents. Therefore anticoagulation of cancer patients with VTE is fraught with difficulty. This audit of hospice inpatients taking warfarin showed a high incidence of bleeding which was possibly improved with very stringent international normalized ratio (INR) monitoring: 15 episodes in 17 patients improved to 11 episodes in 18 patients. Patient numbers were small and the two groups heterogeneous, thus formal statistical analysis could not be applied. One patient in each group continued to thrombose despite overanticoagulation with warfarin. Monitoring of INR increased from an average of once every six days to once every 2.4 days. Such frequent monitoring is likely to be highly impractical in many hospice and general practice settings. Control of warfarin as measured by average percentage of INRs in, above or below the therapeutic range if anything appeared to be worse in the second group. Any bleeding in these patients was distressing. As a result of this audit, practice in Huntershill Marie Curie Centre has changed. Low molecular weight heparins are proven to be efficacious in the treatment of VTE, are renally excreted and therefore do not interact with many commonly used concurrent medications. They can be administered once daily and do not need monitoring of anticoagulant effect. Thus they will be used in patients for whom anticoagulation is indicated during a six-month period, after which practice will be again reviewed.
Visuo-motor development which causes detection of visual depth from motion and

This study examines the effectiveness of cues of visual depth and distance in the course of development and how this process depends on visuo-motor development. In the visual pitfall situation, i.e. a modification of Gibson’s visual cliff, eight Japanese monkeys (macaca fuscata) were observed with respect to their depth avoidance and visuo-motor activity. The tests were run once a week from the first until the sixteenth week after birth. Binocular parallax, motion parallax and texture density rates were manipulated to examine their effectiveness as cues. It was shown that for the first two months depth perception depended exclusively on motion parallax, whereas in the third month cues of motion and texture were added. Binocular cues did not have any effect in this age range.Three items of behaviour, i.e. visual regard of depth, head movement, and body movement, were checked and measured to obtain information which could explain the process of development of the cue function. The three items showed different developmental curves. During the first month, visual regard closely concurred with head and body movements, then visual activity suppressed motor behaviour and, after the end of the second month, the two became almost independent of each other. These analyses demonstrated that at a later stage pictorial cues produced an effect additional to the primary motion cues and that the effective cue function was based on the development of visuo-motor activity.
Very young infants learn abstract rules in the visual modality

Abstracting the structure or ‘rules’ underlying observed patterns is central to mature cognition, yet research with infants suggests this far-reaching capacity is initially restricted to certain stimuli. Infants successfully abstract rules from auditory sequences (e.g., language), but fail when the same rules are presented as visual sequences (e.g., shapes). We propose that this apparent gap between rule learning in the auditory and visual modalities reflects the distinct requirements of the perceptual systems that interface with cognition: The auditory system efficiently extracts patterns from sequences structured in time, but the visual system best extracts patterns from sequences structured in space. Here, we provide the first evidence for this proposal with adults in an abstract rule learning task. We then reveal strong developmental continuity: infants as young as 3 months of age also successfully learn abstract rules in the visual modality when sequences are structured in space. This provides the earliest evidence to date of abstract rule learning in any modality.
Quantale-valued Approach Spaces via Closure and Convergence

For a quantale V we introduce V-approach spaces via V-valued point-set-distance functions and, when V is completely distributive, characterize them in terms of both, so-called closure towers and ultrafilter convergence relations. When V is the two-element chain 2, the extended real half-line [0,∞], or the quantale ∆ of distance distribution functions, the general setting produces known and new results on topological spaces, approach spaces, and the only recently considered probabilistic approach spaces, as well as on their functorial interactions with each other.
Appropriating Heuristic Evaluation for Mobile Computing

Heuristic evaluation has proven popular for desktop and web interfaces, both in practical design and as a research topic. Compared to full user studies, heuristic evaluation can be highly cost-effective, allowing a large proportion of usability flaws to be detected ahead of full development with limited resource investment. Mobile computing shares many usability issues with more conventional interfaces. However, it also poses particular problems for usability evaluation related to aspects such as limited screen real estate, intermittent user attention, and contextual factors. This article describes a modified collection of usability heuristics that are designed to be appropriate for evaluation in mobile computing. They have been systematically derived from extensive literature and empirically validated. They therefore offer a sound basis for heuristic-based evaluation in mobile computing. Besides introducing the reader to the practical use of heuristic evaluation, the article also closes with a description of potential future research in the area.
Challenges in the clinical measurement of ocular surface disease in glaucoma patients

Ocular surface disease (OSD) is common among glaucoma patients. Clinical assessment of OSD can be challenging. This review focuses on some of the limitations relating to both subjective and objective measures of OSD, including dry eye. A survey of the literature was conducted to identify the caveats associated with different methods of assessing OSD. The effect of preservatives on the ocular surface, with respect to glaucoma patients in particular, was also reviewed. Objective methods for assessing ocular surface health and disease include the Schirmer test, tear break-up time, fluorescein turnover, corneal and conjunctival staining, tear osmolarity, and vital dyes. These measures all have limitations in terms of their ability to grade the severity of OSD. Previous studies using the OSD Index showed a mild-to-moderate correlation to dry eye disease severity. Other scoring systems for dry eye have shown a relationship to patient symptom scores or quality of life. Due to the challenges clinicians face concerning both subjective and objective ocular surface health assessments, discerning clinical improvement in ocular surface disease can be a challenge. Further research is needed in order to optimize existing clinical methods and/or identify alternative techniques for assessing OSD in the glaucoma population.
Probabilistic voltage solution method for distribution systems with wind electric generators

A distribution system planning exercise forecasts both buswise peak load and annual wind generation and typically these forecasts have different probability distributions. A solution method for power balance equations of such a planned system should include probabilistic modeling of bus loads and wind generation. This paper proposes a probabilistic load flow method for a distribution system that takes into account the stochastic nature of wind generation and forecasted buswise peak load. This paper models the annual wind generation forecast using a Weibull distribution function and the annual buswise peak load forecast using a normal distribution function. Assuming the annual load forecasts and wind generation forecasts as independent probabilistic events and using load-duration curves, several sets of data are created with individual probability of occurrence. Each set of generation and load with a probability of occurrence is used to determine a corresponding voltage solution using a Newton-Raphson Method of solution. The probability distribution functions (PDF) for bus voltages are recreated from the resultant data. The resultant PDFs for voltages and other resultant data are analyzed using a curve fitting technique. The method is tested on a modified 70-bus distribution system and the results are reported.
Verifiable Threshold Sharing of a Large Secret Safe-Prime

Verifiable secret sharing schemes (VSS) are schemes for the purpose of ensuring that the players are sharing a unique secret and this secret is the secret originally distributed by the dealer if the dealer was honest. However, such schemes do not ensure that the shared secret has any special characteristics (such as being a prime, safe prime or being with a specific bit-length). In this paper, we introduce a secret sharing scheme to allow a set of players to have confidence that they are sharing a large secret prime. Next, we introduce another scheme that allows the players to have confidence that they are sharing a large secret safe prime. Finally we give a subroutine that allows the players to ensure that the shared primes are of the appropriate bit-length. What we have in mind is to add fault-tolerance property to the recent all honest RSA function sharing protocol of [11].
Biotechnological applications of functional metagenomics in the food and pharmaceutical industries

Microorganisms are found throughout nature, thriving in a vast range of environmental conditions. The majority of them are unculturable or difficult to culture by traditional methods. Metagenomics enables the study of all microorganisms, regardless of whether they can be cultured or not, through the analysis of genomic data obtained directly from an environmental sample, providing knowledge of the species present, and allowing the extraction of information regarding the functionality of microbial communities in their natural habitat. Function-based screenings, following the cloning and expression of metagenomic DNA in a heterologous host, can be applied to the discovery of novel proteins of industrial interest encoded by the genes of previously inaccessible microorganisms. Functional metagenomics has considerable potential in the food and pharmaceutical industries, where it can, for instance, aid (i) the identification of enzymes with desirable technological properties, capable of catalyzing novel reactions or replacing existing chemically synthesized catalysts which may be difficult or expensive to produce, and able to work under a wide range of environmental conditions encountered in food and pharmaceutical processing cycles including extreme conditions of temperature, pH, osmolarity, etc; (ii) the discovery of novel bioactives including antimicrobials active against microorganisms of concern both in food and medical settings; (iii) the investigation of industrial and societal issues such as antibiotic resistance development. This review article summarizes the state-of-the-art functional metagenomic methods available and discusses the potential of functional metagenomic approaches to mine as yet unexplored environments to discover novel genes with biotechnological application in the food and pharmaceutical industries.
Evaluation of Lateral Spread of Transgene Expression following Subretinal AAV–Mediated Gene Delivery in Dogs

Dog models with spontaneously occurring mutations in retinal dystrophy genes are an invaluable resource for preclinical development of retinal gene therapy. Adeno-associated virus (AAV) vectors have been most successful; to target the outer retina and RPE they are delivered by subretinal injection, causing a temporary retinal detachment with some potential for retinal morbidity. A recent reporter gene study using an AAV2/8 vector in dogs reported transgene expression beyond the boundary of the subretinal bleb. This could be a desirable feature which increases the area of retina treated while minimizing the retinal detachment and any associated morbidity. We performed a detailed study of the lateral spread of transgene expression beyond the subretinal injection site following subretinally delivered AAV vectors in normal dogs. Vectors expressed green fluorescent protein (GFP) using a small chicken beta-actin promoter. AAV2/2 (quadruple tyrosine to phenylalanine (Y-F) capsid mutant), self-complementary (sc) AAV2/8 (single Y-F capsid mutant) and a scAAV2/5 were used. We found that in all eyes GFP expression involved retina beyond the initial post-injection subretinal bleb boundary. In all eyes there was post-injection spread of the retinal detachment within the first 3 days post procedure and prior to retinal reattachment. In 11/16 eyes this accounted for the entire “lateral spread” of GFP expression while in 5/16 eyes a very slight extension of GFP expression beyond the final boundary of the subretinal bleb could be detected. All 3 AAV constructs induced GFP expression in the nerve fiber layer with spread to the optic nerve. Patients treated by subretinal injection should be monitored for possible expansion of the subretinal injection bleb prior to reattachment. Injections in the para-foveal region may expand to lead to a foveal detachment that may be undesirable. Cell-specific promoters may be required to limit spread of expressed transgene to the brain with these AAV serotypes.
Lead and PCBs as Risk Factors for Attention Deficit/Hyperactivity Disorder

Objectives Attention deficit/hyperactivity disorder (ADHD) is the most frequently diagnosed neurobehavioral disorder of childhood, yet its etiology is not well understood. In this review we present evidence that environmental chemicals, particularly polychlorinated biphenyls (PCBs) and lead, are associated with deficits in many neurobehavioral functions that are also impaired in ADHD. Data sources Human and animal studies of developmental PCB or lead exposures that assessed specific functional domains shown to be impaired in ADHD children were identified via searches of PubMed using “lead” or “PCB exposure” in combination with key words, including “attention,” “working memory,” “response inhibition,” “executive function,” “cognitive function,” “behavior,” and “ADHD. ” Data synthesis Children and laboratory animals exposed to lead or PCBs show deficits in many aspects of attention and executive function that have been shown to be impaired in children diagnosed with ADHD, including tests of working memory, response inhibition, vigilance, and alertness. Studies conducted to date suggest that lead may reduce both attention and response inhibition, whereas PCBs may impair response inhibition to a greater degree than attention. Low-level lead exposure has been associated with a clinical diagnosis of ADHD in several recent studies. Similar studies of PCBs have not been conducted. Conclusions We speculate that exposures to environmental contaminants, including lead and PCBs, may increase the prevalence of ADHD.
A novel energy efficient platform based model to enable mobile Cloud applications

Due to the nature of communication, mobility and portability in Mobile Computing, the handling of limited computing, storage and network capabilities become increasingly important especially when more features and richer functionality are required today. Cloud Computing, as an elastic computing utility provisioning framework, is shown to be a promising approach, addressing the concerns in Mobile Computing. Many achievements have been made by researchers regarding how to offload computational tasks from mobile systems to the Cloud. However, the proposed offloading methodologies are mainly from the perspectives of mobile application level, focusing on static estimation, dynamic partitioning, cloning, transmission overhead evaluation and migration. Issues related to multi-core Cloud systems are not fully considered, such as overall energy consumption of Cloud systems, information security, usability and availability. In this paper, a platform-based system model is designed from the view of the Cloud platform, trying to enable these Cloud benefits in addition to offloading, and to provide better execution efficiency and overall energy reduction by utilizing the proposed platform level scheduling. Based on the experiments, the proposed platform scheduling can achieve greater energy reduction with little computing overhead on the management node, compared to application-level scheduling methods.
GPC1 Regulated by miR-96-5p, Rather than miR-182-5p, in Inhibition of Pancreatic Carcinoma Cell Proliferation

To determine the relationships between miR-96-5p/-182-5p and GPC1 in pancreatic cancer (PC), we conducted the population and in vitro studies. We followed 38 pancreatic cancer patients, measured and compared the expression of miR-96-5p/-182-5p, GPC1, characteristics and patients’ survival time of different miR-96-5p/-182-5p expression levels in PC tissues. In an in vitro study, we investigated the proliferation, cycle and apotosis in cells transfected with mimics/inhibitors of the two miRNAs, and determine their effects on GPC1 by dual-luciferase assay. In the follow-up study, we found that the expressions of miR-96-5p/-182-5p were lower/higher in PC tissues; patients with lower/higher levels of miR-96-5p/-182-5p suffered poorer characteristics and decreased survival time. In the in vitro study, the expressions of miR-96-5p/-182-5p were different in cells. Proliferation of cells transfected with miR-96-5p mimics/inhibitors was lower/higher in Panc-1/BxPC-3; when transfected with miR-182-5p mimics/inhibitors, proliferation of cells were higher/lower in AsPC-1/Panc-1. In a cell cycle study, panc-1 cells transfected with miR-96-5p mimics was arrested at G0/G1; BxPC-3 cells transfected with miR-96-5p inhibitors showed a significantly decrease at G0/G1; AsPC-1 cells transfected with miR-182-5p mimics was arrested at S; Panc-1 cells transfected with miR-182-5p inhibitors showed a decrease at S. MiR-96-5p mimics increased the apoptosis rate in Panc-1 cells, and its inhibitors decreased the apoptosis rate in BxPC-3. Dual luciferase assay revealed that GPC1 was regulated by miR-96-5p, not -182-5p. We found that miR-96-5p/-182-5p as good markers for PC; miR-96-5p, rather than -182-5p, inhibits GPC1 to suppress proliferation of PC cells.
Cornu Ammonis Regions–Antecedents of Cortical Layers?

Studying neocortex and hippocampus in parallel, we are struck by the similarities. All three to four layered allocortices and the six layered mammalian neocortex arise in the pallium. All receive and integrate multiple cortical and subcortical inputs, provide multiple outputs and include an array of neuronal classes. During development, each cell positions itself to sample appropriate local and distant inputs and to innervate appropriate targets. Simpler cortices had already solved the need to transform multiple coincident inputs into serviceable outputs before neocortex appeared in mammals. Why then do phylogenetically more recent cortices need multiple pyramidal cell layers? A simple answer is that more neurones can compute more complex functions. The dentate gyrus and hippocampal CA regions—which might be seen as hippocampal antecedents of neocortical layers—lie side by side, albeit around a tight bend. Were the millions of cells of rat neocortex arranged in like fashion, the surface area of the CA pyramidal cell layers would be some 40 times larger. Even if evolution had managed to fold this immense sheet into the space available, the distances between neurones that needed to be synaptically connected would be huge and to maintain the speed of information transfer, massive, myelinated fiber tracts would be needed. How much more practical to stack the “cells that fire and wire together” into narrow columns, while retaining the mechanisms underlying the extraordinary precision with which circuits form. This demonstrably efficient arrangement presents us with challenges, however, not the least being to categorize the baffling array of neuronal subtypes in each of five “pyramidal layers. ” If we imagine the puzzle posed by this bewildering jumble of apical dendrites, basal dendrites and axons, from many different pyramidal and interneuronal classes, that is encountered by a late-arriving interneurone insinuating itself into a functional circuit, we can perhaps begin to understand why definitive classification, covering every aspect of each neurone's structure and function, is such a challenge. Here, we summarize and compare the development of these two cortices, the properties of their neurones, the circuits they form and the ordered, unidirectional flow of information from one hippocampal region, or one neocortical layer, to another.
Evaluating Phonological Processing Skills in Children With Prelingual Deafness Who Use Cochlear Implants

This study investigated the phonological processing skills of 29 children with prelingual, profound hearing loss with 4 years of cochlear implant experience. Results were group matched with regard to word-reading ability and mother’s educational level with the performance of 29 hearing children. Results revealed that it is possible to obtain a valid measure of phonological processing (PP) skills in children using CIs. They could complete rhyming tasks and were able to complete sound-based tasks using standard test materials provided by a commercial test distributor. The CI children completed tasks measuring PP, but there were performance differences between the CI users and the hearing children. The process of learning phonological awareness (PA) for the children with CIs was characterized by a longer, more protracted learning phase than their counterparts with hearing. Tests of phonological memory skills indicated that when the tasks were controlled for presentation method and response modality, there were no differences between the performance of children with CIs and their counterparts with hearing. Tests of rapid naming revealed that there were no differences between rapid letter and number naming between the two groups. Results yielded a possible PP test battery for children with CI experience.