Miracle-dz/UniFAR-FTUs huggingface dataset:
OpenIDemail enabled browser: towards fixing the broken web single sign-on triangle

Current Web single sign-on (SSO) solutions impose a cognitive burden on web users and do not provide content-hosting and service providers (CSPs) with sufficient incentives to become relying parties (RPs). We propose a browser-based Web SSO solution that requires minimal user interaction and provide RPs with clear value propositions to motivate their adoption. Our approach builds OpenID support into web browsers, hides OpenID identifiers from users by using their existing email accounts, extends the OpenID protocol to perform authentication directly by browsers, and introduces an OpenIDAuth HTTP access authentication scheme to convey authenticated identities automatically into websites that support OpenID for authentication. Our solution embeds an intuitive and consistent login experience for web users in the browser; to motivate adoption by RPs, it provides them with instant marketable leads and the potential for gradual engagement of site visitors.
Preservation of Redox, Polyamine, and Glycine Domains of the N‐Methyl‐D‐Aspartate in Alzheimer's Disease

Abstract: This study used [3H] dizocilpine ([3H] MK‐801) binding to the N‐methyl‐D‐aspartate (NMDA) receptor to examine redox, polyamine, and glycine modulatory sites in membranes derived from the superior frontal and the superior temporal cortex of patients with Alzheimer's disease. In control subjects the competitive polyamine site antagonist arcaine inhibited [3H] dizocilpine binding in a dose‐dependent fashion and this curve was shifted to the right by the addition of 50 μM spermidine. Arcaine inhibition of binding was more potent in the temporal cortex than in the frontal cortex, in both the absence and presence of 50 μMspermidine. In Alzheimer's disease, arcaine inhibition of [3H] dizocilpine binding (in both the absence and the presence of spermidine) was not different from control in either of the two brain areas examined. The sulfhydryl redox site of the NMDA receptor was assessed using the oxidizing agent 5, 5′‐dithio‐bis(2‐nitrobenzoic acid), which inhibited binding in a dose‐dependent fashion. This inhibition was similar in patients with Alzheimer's disease and control subjects. Glycine‐stimulated [3H] dizocilpine binding was also unaffected in patients with Alzheimer's disease. However, in the temporal cortex there was a significant age‐associated decline in [3H] dizocilpine binding in the presence of 100 μM glutamate (R8=‐0.71) and 100 μM glutamate plus 30 μM glycine (R8=−0.90). There was also an age‐related increase in arcaine IC50 (which reflects an age‐related decrease in arcaine affinity) in the frontal cortex, determined both in the absence (R8= 0.83) and the presence (R8= 0.79) of spermidine. These data indicate that the NMDA receptor and its modulatory redox, polyamine, and glycine subsites are intact in patients with Alzheimer's disease and that the modulatory activity of polyamine and glycine sites decline with aging.
RSC y organizaciones virtuales: nuevos esquemas de compromiso de los profesionales.

El objetivo de este trabajo es profundizar en la transformacion de las motivaciones de los trabajadores en las organizaciones virtuales. Avanzar hacia organizaciones en red requiere un fuerte compromiso de los profesionales para la gestion del cambio, sin embargo, una vez se alejan del modelo de acudir diariamente al centro de trabajo, puede bajar su identidad social, especialmente si se tiene alta necesidad de afi liacion. De forma complementaria las TIC y los modelos en red pueden aumentar la cercania a organizaciones de actividad complementarias, como las ONG. Estas tres hipotesis se demuestran en la investigacion realizada, a la par que se tratan de identifi car los nuevos motivadores, ligados, al menos en parte, a la direccion por valores y a las politicas de RSC.
Joined for the common purpose

Purpose - The purpose of this paper is to investigate the emergence and endurance of the Institute of Chartered Accountants in Ireland (ICAI) as an all-Ireland body formed in the context of political and religious upheaval. It seeks to explore the motives for the north-south accounting alliance and the strategies adopted by the institute to negotiate the destructive and divisive forces of the wider socio-political environment. Design/methodology/approach - A multitude of archival material is used to reconstruct the post-formation activities of the ICAI. Sources were drawn from: the ICAI archive in Dublin: Findings - The early ICAI was an overwhelmingly Protestant/Unionist dominated body seeking to maintain Protestant hegemony at a time when the power of this class was being gradually eroded. Cognizant of the likely vulnerability of such a body existing in the catholic-nationalist south, and the need to strengthen such a position through a northern alliance, the ICAI from its inception was envisaged by its southern architects as an all Ireland institution. The fact that there were only a relatively small number of members acted as an inducement, particularly for Protestant members, to maintain unity. Originality/value - The professionalization of accountancy in Ireland has been relatively under-researched and the debates about the diffusion of the English professional model have virtually bypassed it.
Single Multiplex PCR Assay To Identify Simultaneously the Six Categories of Diarrheagenic Escherichia coli Associated with Enteric Infections

ABSTRACT We designed a multiplex PCR for the detection of all categories of diarrheagenic Escherichia coli. This method proved to be specific and rapid in detecting virulence genes from Shiga toxin-producing (stx1, stx2, and eae), enteropathogenic (eae and bfp), enterotoxigenic (stII and lt), enteroinvasive (virF and ipaH), enteroaggregative (aafII), and diffuse adherent (daaE) Escherichia coli in stool samples.
Analysis of the role of TFIIE in basal transcription and TFIIH-mediated carboxy-terminal domain phosphorylation through structure-function studies of TFIIE-alpha

The general transcription factor TFIIE recruits TFIIH at a late stage of transcription initiation complex formation and markedly stimulates TFIIH-dependent phosphorylation of the carboxy-terminal domain (CTD) of RNA polymerase II. To study this function of TFIIE in more detail, systematic deletion mutations were introduced into the large subunit of TFIIE (TFIIE-alpha) and were analyzed with regard to their effects on TFIIH-dependent CTD phosphorylation, TFIIE-dependent basal and enhancer-dependent transcription, and interactions of TFIIE-alpha with both TFIIE-beta and TFIIH. The amino (N)-terminal half of TFIIE-alpha, which possesses several putative structural motifs, was sufficient for the phosphorylation and transcription activities and for TFIIE-beta interactions, whereas a site effecting both strong interactions with TFIIH and large stimulatory effects on transcription and CTD phosphorylation was localized to an acidic region near the carboxy (C) terminus. The fact that these activities appear to be tightly linked supports the idea that TFIIE interacts physically and functionally with TFIIH and that CTD phosphorylation is essential for transcription under normal conditions. The present results suggest that TFIIE, via its effect on TFIIH, may act as a checkpoint for formation of a preinitiation complex.
Effects of Nasal High Flow on Ventilation in Volunteers, COPD and Idiopathic Pulmonary Fibrosis Patients

Background: A high flow of air applied by large bore nasal cannulae has been suggested to improve symptoms of chronic respiratory insufficiency. In pediatric patients, nasal high-flow (nHF) ventilation was similarly effective compared to noninvasive ventilation with a face mask. Objectives: The aim of this study was to describe changes in respiratory parameters. Methods: We measured pressure amplitudes during the respiratory cycle and mean pressures in patients with idiopathic pulmonary fibrosis (IPF) and COPD. In order to achieve tidal volume and minute volume measurements, we used a polysomnography device. Capillary blood was taken for blood gas analysis before and after nHF breathing (8 h). Results: nHF led to an increase in pressure amplitude and mean pressure in healthy volunteers and in patients with COPD and IPF in comparison with spontaneous breathing. In COPD, nHF increased tidal volume, while no difference in tidal volume was observed in patients with IPF. Interestingly, tidal volume decreased in healthy volunteers. Breathing rates and minute volumes were reduced in all groups. Capillary pCO2 decreased in patients with IPF and COPD. Conclusions: nHF resulted in significant effects on respiratory parameters in patients with obstructive and restrictive pulmonary diseases. The rise in pressure amplitude and mean pressure and the decrease in breathing rate and minute volume will support inspiratory efforts, helps to increase effectiveness of ventilation and will contribute to a reduction in the work of breathing. A CO2 wash-out effect in the upper airway part of the anatomical dead space may contribute to the beneficial effects of the nHF instrument.
A New Phase-Angle Measurement Algorithm Based on Virtual $\alpha \beta$ Stationary Coordinate

This letter proposes a novel phase-angle measurement algorithm through establishing a mathematical model of virtual αβ stationary coordinate that utilizes two expression forms of a positive-sequence component in two axes stationary reference frame. This method could greatly eliminate the sinusoidal error of the conventional discrete Fourier transform (DFT) algorithm. The accuracy and performance of the proposed algorithm are proved by relevant simulation results.
Spline Adaptation in Extended Linear Models

In many statistical applications, nonparametric modeling can provide insights into the features of a dataset that are not obtainable by other means. One successful approach involves the use of (univariate or multivariate) spline spaces. As a class, these methods have inherited much from classical tools for parametric modeling. For example, stepwise variable selection with spline basis terms is a simple scheme for locating knots (breakpoints) in regions where the data exhibit strong, local features. Similarly, candidate knot configurations (generated by this or some other search technique), are routinely evaluated with traditional selection criteria like AIC or BIC. In short, strategies typically applied in parametric model selection have proved useful in constructing flexible, low-dimensional models for nonparametric problems. Until recently, greedy, stepwise procedures were most frequently suggested in the literature. Research into Bayesian variable selection, however, has given rise to a number of new spline-based methods that primarily rely on some form of Markov chain Monte Carlo to identify promising knot locations. In this paper, we consider various alternatives to greedy, determin-istic schemes, and present a Bayesian framework for studying adaptation in the context of an extended linear model (ELM). Our major test cases are Logspline density estimation and (bivariate) Triogram regression models. We selected these because they illustrate a number of computational and method-ological issues concerning model adaptation that arise in ELMs.
Mechanical Instabilities as a Central Issue for InSilico Analysis of Cell Dynamics

Even if the leading role of mechanical forces in tissue growth and remodeling is well admitted, it is only recently that the effects of physical forces on gene expression and cell dynamics have been more extensively investigated. In this multiscale context, developing in silico models of cells and tissues is necessary to understand how biochemical and biomechanical cell signaling pathways interplay to specify a wide range of cellular dynamical processes and tissue architectures. In this paper, we review modeling approaches exemplifying how mechanical instabilities may drive emergent biological processes at different scales. At the cell level,we discuss the self-organized character of cell protrusions dynamics and the associated oscillatory cell shape changes modulated by the cell cortex contractility. At the cell population level, we analyze how the in vitro morphogenesis of endothelial cell networks can be enhanced or inhibited by modifications of the mechanical homeostasis of the cell/extracellular matrix medium. We finally outline how our understanding of such mechanical instabilities may support tissue engineering approaches in which transduction of mechanical forces has to be optimized in order to obtain specific cellular responses and tissue functional properties.
Combining the Global and Partial Information for Distance-Based Time Series Classification and Clustering

Many time series representation schemes for classification and clustering have been proposed. Most of the proposed representation focuses on the prominent series by considering the global information of the time series. The partial information of time series that indicates the local change of time series is often ignored. Recently, researches shown that the partial information is also important for time series mining. However, the combination of these two types of information has not been well studied in the literature. Moreover, most of the proposed time series representation requires predefined parameters. The classification and clustering results are considerably influenced by the parameter settings, and, users often have difficulty in determining the parameters. We attack above two problems by exploiting the multiscale property of wavelet decomposition. The main contributions of this work are: (1) extracting features combining the global information and partial information of time series (2) automatically choosing appropriate features, namely, features in an appropriate wavelet decomposition scale according to the concentration of wavelet coefficients within this scale. Experiments performed on several benchmark time series datasets justify the usefulness of the proposed approach.
The Arabidopsis SKU5 Gene Encodes an Extracellular Glycosyl Phosphatidylinositol–Anchored Glycoprotein Involved in Directional Root Growth Online version contains Web-only data. Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.002360.

To investigate how roots respond to directional cues, we characterized a T-DNA–tagged Arabidopsis mutant named sku5 in which the roots skewed and looped away from the normal downward direction of growth on inclined agar surfaces. sku5 roots and etiolated hypocotyls were slightly shorter than normal and exhibited a counterclockwise (left-handed) axial rotation bias. The surface-dependent skewing phenotype disappeared when the roots penetrated the agar surface, but the axial rotation defect persisted, revealing that these two directional growth processes are separable. The SKU5 gene belongs to a 19-member gene family designated SKS (SKU5 Similar) that is related structurally to the multiple-copper oxidases ascorbate oxidase and laccase. However, the SKS proteins lack several of the conserved copper binding motifs characteristic of copper oxidases, and no enzymatic function could be assigned to the SKU5 protein. Analysis of plants expressing SKU5 reporter constructs and protein gel blot analysis showed that SKU5 was expressed most strongly in expanding tissues. SKU5 was glycosylated and modified by glycosyl phosphatidylinositol and localized to both the plasma membrane and the cell wall. Our observations suggest that SKU5 affects two directional growth processes, possibly by participating in cell wall expansion.
New experimental model of exposure to environmental tobacco smoke.

PURPOSE To describe a new model to passive smoking for rodents. METHODS Twenty rats were distributed into two study groups (N=10): control group (CG), that was not exposed to tobacco smoke and used as normal standard for biochemical and histological analysis; Experimental Group (EG), that Animals were exposed to the passive smoking; Euthanasia was performed after 14 days of exposure. The serum level of nicotine and histological analysis were performed. RESULTS There was a statistical difference on the nicotine serum levels between Experimental and Control group, with level of 286 ± 23 nanograma/mL in the EG and undetectable on CG (p<0.01). The histological study suggested the model efficacy producing alveolar destruction and emphysema in the EG compared with the insignificant lesions in the CG's lung. CONCLUSION The model of exposure to environmental tobacco smoke for rodents induced easily the changes related to secondhand smoke.
Moderation technique for sexually explicit content

As we know internet is a beautiful thing. But it can lead to enmities, if not used properly. As the use of internet is growing participation of user is also growing. Through internet we can make world smaller by communicating, sharing, posting, tagging information's to people. As informative internet is, it can also be non-informative. This non-informative information is of no use in a business oriented websites. So such non-informative content should be moderated from websites which holds a brand of company. So in this paper non-informative content is moderated before it is to be posted. Text, Image, Videos are scrutinized based on conditions applied, if any of these fall in the category it won't allow to post on the wall. This will maintain harmony of websites as well as brand of company. Different moderation techniques have been discussed for better understanding below. Graphs represent the case study done by different brands which contain maximum non-informative content.
Uptake of cadmium and zinc by the alga Chlorella vulgaris: Part 1. Individual ion species

The ability of algae and bacteria to accumulate heavy metals from the surrounding environment is a widely recognized phenomenon that has a number of important implications. This work reports on the development of a quantitative model that addresses the basic mechanisms inherent in many uptake processes. The model postulates two mechanisms: an initial rapid metal ion uptake due to attachment onto the cell wall followed by a relatively slow uptake due to membrane transport of the metal into the cell. The mathematical model has been tested using the alga Chlorella vulgaris in the presence of cadmium and zinc in solution under various experimental conditions.
Phosphatidylserine Decarboxylase 2 of Saccharomyces cerevisiáe

The yeast Saccharomyces cerevisiae expresses two phosphatidylserine decarboxylase (PSD) activities which are responsible for conversion of phosphatidylserine to phosphatidylethanolamine, and either enzyme alone is sufficient for normal cellular growth. However, strains containing a PSD1 null allele and a mutation leading to loss of PSD2 activity (psd1-Δ1::TRP1 psd2) are auxotrophic for ethanolamine. This nutritional requirement was utilized to isolate the gene encoding the PSD2 enzyme by complementation. The PSD2 gene encodes a protein of 1138 amino acids with a predicted molecular mass of 130 kDa. The deduced amino acid sequence shows significant identity (34%) to a PSD-like sequence from Clostridium pasteurianum and the yeast PSD1 (19%) at the carboxyl end of the protein. Of particular interest is the presence of a sequence, GGST, which may be involved in post-translational processing and prosthetic group formation similar to other PSD enzymes. The PSD2 amino acid sequence also shows significant homology to the C2 regions of protein kinase C and synaptotagmin. Physical mapping experiments demonstrate that the PSD2 is located on chromosome 7. The PSD2 gene was heterologously expressed by infection of Sf-9 insect cells with recombinant baculovirus, resulting in a 10-fold increase in PSD activity. The null allele of PSD2 was introduced into yeast strains by one-step gene deletion/disruption with a HIS3 marker gene. Strains expressing wild type PSD1 and the psd2-Δ1::HIS3 allele show a small decrease in overall PSD activity, but no noticeable effect upon [3H]serine incorporation into aminophospholipids. Strains containing both the psd1-Δ1::TRP1 and psd2-Δ1::HIS3 null alleles, however, express no detectable PSD activity, are ethanolamine auxotrophs and show a severe deficit in the conversion of [3H]serine-labeled phosphatidylserine to phosphatidylethanolamine. These data indicate that the gene isolated is the structural gene for PSD2 and that the PSD1 and PSD2 enzymes account for all yeast PSD activity.
Towards an Effective Unified Programming Model for Many-Cores

Building an effective programming model for many-core processors is challenging. On the one hand, the increasing variety of platforms and their specific programming models force users to take a hardware-centric approach not only for implementing parallel applications, but also for designing them. This approach diminishes portability and, eventually, limits performance. On the other hand, to effectively cope with the increased number of large-scale workloads that require parallelization, a portable, application-centric programming model is desirable. Such a model enables programmers to focus first on extracting and exploiting parallelism from their applications, as opposed to generating parallelism for specific hardware, and only second on platform-specific implementation and optimizations. In this paper, we first present a survey of programming models designed for programming three families of many-cores: general purpose many-cores (GPMCs), graphics processing units (GPUs), and the Cell/B.E. We analyze the usability of these models, their ability to improve platform programmability, and the specific features that contribute to this improvement. Next, we also discuss two types of generic models: parallelism-centric and application-centric. We also analyze their features and impact on platform programmability. Based on this analysis, we recommend two application-centric models (OmpSs and OpenCL) as promising candidates for a unified programming model for many-cores and we discuss potential enhancements for them.
Automatic Recognition of Aggressive Behavior in Pigs Using a Kinect Depth Sensor

Aggression among pigs adversely affects economic returns and animal welfare in intensive pigsties. In this study, we developed a non-invasive, inexpensive, automatic monitoring prototype system that uses a Kinect depth sensor to recognize aggressive behavior in a commercial pigpen. The method begins by extracting activity features from the Kinect depth information obtained in a pigsty. The detection and classification module, which employs two binary-classifier support vector machines in a hierarchical manner, detects aggressive activity, and classifies it into aggressive sub-types such as head-to-head (or body) knocking and chasing. Our experimental results showed that this method is effective for detecting aggressive pig behaviors in terms of both cost-effectiveness (using a low-cost Kinect depth sensor) and accuracy (detection and classification accuracies over 95.7% and 90.2%, respectively), either as a standalone solution or to complement existing methods.