Miracle-dz/UniFAR-FTUs huggingface dataset:
WORM-HUNTER: A Worm Guard System using Software-defined Networking

Network security is rapidly developing, but so are attack methods. Network worms are one of the most widely used attack methods and have are able to propagate quickly. As an active defense approach to network worms, the honeynet technique has long been limited by the closed architecture of traditional network devices. In this paper, we propose a closed loop defense system of worms based on a Software-Defined Networking (SDN) technology, called Worm-Hunter. The flexibility of SDN in network building is introduced to structure the network infrastructures of Worm-Hunter. By using well-designed flow tables, Worm-Hunter is able to easily deploy different honeynet systems with different network structures and dynamically. When anomalous traffic is detected by the analyzer in Worm-Hunter, it can be redirected into the honeynet and then safely analyzed. Throughout the process, attackers will not be aware that they are caught, and all of the attack behavior is recorded in the system for further analysis. Finally, we verify the system via experiments. The experiments show that Worm-Hunter is able to build multiple honeynet systems on one physical platform. Meanwhile, all of the honeynet systems with the same topology operate without interference.
Discrepancy between the Atwater factor predicted and empirically measured energy values of almonds in human diets1234

Background: The energy content of foods is primarily determined by the Atwater factors, which may not be accurate for certain food groups. Nuts are a food group for which substantial evidence suggests that the Atwater factors may be poorly predictive. Objective: A study was conducted to determine the energy value of almonds in the human diet and to compare the measured energy value with the value calculated from the Atwater factors. Design: Eighteen healthy adults consumed a controlled diet or an almond-containing diet for 18 d. Three treatments were administered to subjects in a crossover design, and diets contained 1 of 3 almond doses: 0, 42, or 84 g/d. During the final 9 d of the treatment period, volunteers collected all urine and feces, and samples of diets, feces, and urine were analyzed for macronutrient and energy contents. The metabolizable energy content of the almonds was determined. Results: The energy content of almonds in the human diet was found to be 4.6 ± 0.8 kcal/g, which is equivalent to 129 kcal/28-g serving. This is significantly less than the energy density of 6.0–6.1 kcal/g as determined by the Atwater factors, which is equivalent to an energy content of 168–170 kcal/serving. The Atwater factors, when applied to almonds, resulted in a 32% overestimation of their measured energy content. Conclusion: This study provides evidence for the inaccuracies of the Atwater factors for certain applications and provides a rigorous method for determining empirically the energy value of individual foods within the context of a mixed diet. This trial was registered at clinicaltrials.gov as NCT01007188.
Clinicians' Views on Management and Terminology for Papillary Thyroid Microcarcinoma: A Qualitative Study.

BACKGROUND There is growing acceptance that the increase in thyroid cancer incidence is in part a result of overdiagnosis of small low-risk papillary microcarcinomas (PMCs) with indolent clinical course. Although surgery is the cornerstone treatment for patients with PMCs, recent management guidelines are shifting toward inclusion of more conservative treatments such as active surveillance. There is little evidence on clinicians' experience in managing PMC patients and their attitudes toward treatment options, including their willingness to accept a nonsurgical option. The aim of this study was to understand how clinicians perceive a diagnosis of PMC, potential changes to terminology, and the treatment options available to patients. METHODS This was a qualitative study using semi-structured interviews conducted between November 2015 and May 2016 with 22 clinicians (seven endocrinologists and 15 thyroid surgeons). Transcribed audio-recordings were thematically coded, and a framework method was used to analyze the data. RESULTS Across a sample of clinicians who manage thyroid cancer patients, awareness of overdiagnosis and overtreatment of PMC was common. However, there was little acceptance of active surveillance to manage these patients. Clinicians did not feel comfortable recommending this management approach, as they were worried about the risk of metastases, did not feel that evidence to support this approach was strong enough, and also believed that patients currently have a high preference for surgery. The majority of clinicians did not believe that changing the terminology of this diagnosis was a viable strategy to reduce patients' anxiety and their perceived preference for more aggressive treatments. However, most clinicians felt that thyroid nodules <1 cm should not be biopsied, which could help minimize the risk of overdiagnosis of PMC. CONCLUSIONS This study, based on a non-representative sample of 22 clinicians, which remains an important limitation, provides revealing insight into clinicians' management preferences and decision making for small low-risk thyroid cancers at a time when management guidelines and practices are evolving. It suggests that clinicians may not be ready to accept nonsurgical options, or changes in terminology, until evidence to support these options and changes is stronger.
An Analysis of Block Sampling Strategies in Compressed Sensing

Compressed sensing is a theory which guarantees the exact recovery of sparse signals from a small number of linear projections. The sampling schemes suggested by current compressed sensing theories are often of little practical relevance, since they cannot be implemented on real acquisition systems. In this paper, we study a new random sampling approach that consists of projecting the signal over blocks of sensing vectors. A typical example is the case of blocks made of horizontal lines in the 2-D Fourier plane. We provide the theoretical results on the number of blocks that are sufficient for exact sparse signal reconstruction. This number depends on two properties named intra- and inter-support block coherence. We then show that our bounds coincide with the best so far results in a series of examples, including Gaussian measurements or isolated measurements. We also show that the result is sharp when used with specific blocks in time-frequency bases, in the sense that the minimum required amount of blocks to reconstruct sparse signals cannot be improved up to a multiplicative logarithmic factor. The proposed results provide a good insight on the possibilities and limits of block compressed sensing in imaging devices, such as magnetic resonance imaging, radio-interferometry, or ultra-sound imaging.
Pyrethroid Insecticide Cypermethrin Modulates Gonadotropin Synthesis via Calcium Homeostasis and ERK1/2 Signaling in L&bgr;T2 Mouse Pituitary Cells

Pyrethroids are a class of widely used insecticides. Cypermethrin (CP) is one of most commonly used pyrethroid insecticides and its residue has been frequently detected in environmental media. Our recent animal study reported that early postnatal exposure to CP induced an increase in serum levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) as well as the expression of gonadotropin subunit genes (chorionic gonadotropin α [CGα], LHβ and FSHβ) in pituitary tissues. In this study, we further investigated the precise mechanism by which CP at concentrations of 1-100 nM affected the synthesis of gonadotropins using a murine pituitary gonadotropic cell line LβT2. We found that calcium (Ca2+)-dependent extracellular signal-regulated kinase 1/2 (ERK1/2) activity was required for CP-regulated transcription of CGαs, LHβ and FSHβ. We provided the novel evidence that CP caused both influx of extracellular Ca2+ through L-type voltage-gated calcium channels (VGCCs) and release of intracellular Ca2+ from endoplasmic reticulum (ER) via inhibition of Ca2+-ATPase. Our results showed that CP disrupted Ca2+ homeostasis via these two separate and independent pathways, thus resulting in the activation of protein kinase C /c-Raf/ERK1/2/immediate-early genes pathways and subsequent increase in the transcription of gonadotropin subunit genes. Our findings would have important implications for understanding the underlying mechanisms of the disrupting effects of some pyrethroids (such as CP) on the synthesis of pituitary gonadotropins.
The Hemagglutinin-Neuraminidase (HN) Head Domain and the Fusion (F) Protein Stalk Domain of the Parainfluenza Viruses Affect the Specificity of the HN-F Interaction

Membrane fusion by the parainfluenza viruses is induced by virus-specific functional interaction between the attachment protein (HN) and the fusion (F) protein. This interaction is thought to be mediated by transient contacts between particular amino acids in the HN stalk domain and those in the F head domain. However, we recently reported that replacement of specified amino acids at or around the dimer interface of the HN head domain remarkably affected the F protein specificity. We then intended to further investigate this issue in the present study and revealed that the HPIV2 HN protein can be converted to an SV41 HN-like protein by substituting at least nine amino acids in the HPIV2 HN head domain with the SV41 HN counterparts in addition to the replacement of the stalk domain, indicating that specified amino acids in the HN head domain play very important roles in determining the specificity of the HN-F interaction. On the other hand, we previously reported that the PIV5 F protein can be converted to an SV41 F-like protein by replacing 21 amino acids in the head domain of the PIV5 F protein with those of the SV41 F protein. We then intended to further investigate this issue in the present study and found that replacement of 15 amino acids in the stalk domain in addition to the replacement of the 21 amino acids in the head domain of the PIV5 F protein resulted in creation of a more SV41 F-like protein, indicating that specified amino acids in the F stalk domain play important roles in determining the specificity of the HN-F interaction. These results suggest that the conformations of the HN stalk domain and the F head domain are dependent on the structures of the HN head domain and the F stalk domain, respectively. Presumably, the conformations of the former domains, which are considered directly involved in the HN-F interaction, can be modified by subtle changes in the structure of the latter domains, resulting in an altered specificity for the interacting partners.
Analysis and elimination of the output voltage imbalance for a half‐bridge boost rectifier under mismatched loads

In this letter, the voltage imbalance between the dual output DC voltages of a half‐bridge boost rectifier with mismatched loads is analyzed by adopting an averaged circuit model. A compensating signal proportional to the voltage difference is added in the current command to eliminate the voltage imbalance. In addition, the adverse effects of the compensating current to the input power factor are discussed. Experimental results on a prototype circuit are given to confirm the theoretical analysis. Copyright © 2007 John Wiley & Sons, Ltd.
Systolic Blood Pressure Within 24 Hours After Thrombectomy for Acute Ischemic Stroke Correlates With Outcome

Background Current guidelines suggest treating blood pressure above 180/105 mm Hg during the first 24 hours in patients with acute ischemic stroke undergoing any form of recanalization therapy. Currently, no studies exist to guide blood pressure management in patients with stroke treated specifically with mechanical thrombectomy. We aimed to determine the association between blood pressure parameters within the first 24 hours after mechanical thrombectomy and patient outcomes. Methods and Results We retrospectively studied a consecutive sample of adult patients who underwent mechanical thrombectomy for acute ischemic stroke of the anterior cerebral circulation at 3 institutions from March 2015 to October 2016. We collected the values of maximum, minimum, and average values of systolic blood pressure, diastolic blood pressure, and mean arterial pressures in the first 24 hours after mechanical thrombectomy. Primary and secondary outcomes were patients’ functional status at 90 days measured on the modified Rankin scale and the incidence and severity of intracranial hemorrhages within 48 hours. Associations were explored using an ordered multivariable logistic regression analyses. A total of 228 patients were included (mean age 65.8±14.3; 104 males, 45.6%). Maximum systolic blood pressure independently correlated with a worse 90‐day modified Rankin scale and hemorrhagic complications within 48 hours (adjusted odds ratio=1.02 [1.01–1.03], P=0.004; 1.02 [1.01–1.04], P=0.002; respectively) in multivariable analyses, after adjusting for several possible confounders. Conclusions Higher peak values of systolic blood pressure independently correlated with worse 90‐day modified Rankin scale and a higher rate of hemorrhagic complications. Further prospective studies are warranted to identify whether systolic blood pressure is a therapeutic target to improve outcomes.
Lung Injury after Cardiopulmonary Bypass

Pulmonary injury during cardiopulmonary bypass is common as patient factors (smoking, pain, pneumonia) and the effects of cardiopulmonary bypass combine to compromise lung function after cardiac surgery. Lung injury follows the propagation of an inflammatory response involving cytokines, complement, neutrophils, monocytes, activated endothelial cells and platelets. Neutrophils sequester in the lung in response to chemo-tactic agents and release injurious oxygen free radicals and specific enzymes resulting in widespread pulmonary injury. To alleviate this lung injury a number of possible interventions exist. Off pump surgery may reduce the degree of systemic inflammation but respiratory impairment still occurs and the clinical advantage is uncertain. The use of leukocyte filtration can attenuate the acute inflammatory response with encouraging though variable results. Aprotinin, Pentoxyfilline, Nitric oxide, Aspirin and other agents have shown benefits in lung function after cardiopulmonary bypass induced lung injury. Given the magnitude and diversity of the inflammatory response to cardiopulmonary bypass many possible interventions exist to attenuate lung injury resulting from extracorporeal circulation. Immediate clinical benefits are likely to result from successful amelioration of the processes involved.
Interactive Video Colorization Within a Variational Framework

This paper deals with the difficult problem of video colorization. Methods in the literature are generally based on spatio-temporal video blocks, or on frame to frame color propagation methods, each technique having its own advantages and drawbacks. In this paper , we present both a novel automatic frame-to-frame propagation approach and an interactive correction method within a variational framework. The proposed method propagates colors from an initial colorized frame to the whole grayscale video sequence. The automatic propagation results may be visually unsuitable in some cases. To overcome this limitation, a spatio-temporal functional with a user-guided correction is introduced. Two primal-dual algorithms are designed to solve the proposed variational models. Numerical results show the efficiency and the potentiality of the proposed approach in comparison with state-of-the-art methods.
Fast Benchtop Fabrication of Laminar Flow Chambers for Advanced Microscopy Techniques

Background Fluid handling technology is acquiring an ever more prominent place in laboratory science whether it is in simple buffer exchange systems, perfusion chambers, or advanced microfluidic devices. Many of these applications remain the providence of laboratories at large institutions with a great deal of expertise and specialized equipment. Even with the expansion of these techniques, limitations remain that frequently prevent the coupling of controlled fluid flow with other technologies, such as coupling microfluidics and high-resolution position and force measurements by optical trapping microscopy. Method Here we present a method for fabrication of multiple-input laminar flow devices that are optically clear [glass] on each face, chemically inert, reusable, inexpensive, and can be fabricated on the benchtop in approximately one hour. Further these devices are designed to allow flow regulation by a simple gravity method thus requiring no specialized equipment to drive flow. Here we use these devices to perform total internal reflection fluorescence microscopy measurements as well as position sensitive optical trapping experiments. Significance Flow chamber technology needs to be more accessible to the general scientific community. The method presented here is versatile and robust. These devices use standard slides and coverslips making them compatible with nearly all types and models of light microscopes. These devices meet the needs of groups doing advanced optical trapping experiments, but could also be adapted by nearly any lab that has a function for solution flow coupled with microscopy.
WCRF/AICR recommendation adherence and breast cancer incidence among postmenopausal women with and without non‐modifiable risk factors

Taller height, family history of breast cancer, greater number of years of potential fertility and nulliparity are established non‐modifiable risk factors for postmenopausal breast cancer. Greater adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) diet, physical activity and body weight recommendations has previously been shown to be associated with lower breast cancer risk. However, no prior studies have evaluated whether women with non‐modifiable risk factors receive similar benefits from recommendation adherence compared to women without these risk factors. In the Iowa Women's Health Study prospective cohort, we investigated whether associations of WCRF/AICR recommendation adherence differed by the presence/absence of non‐modifiable breast cancer risk factors. Baseline (1986) questionnaire data from 36,626 postmenopausal women were used to create adherence scores for the WCRF/AICR recommendations (maximum score = 8.0). Overall and single recommendation adherence in relation to breast cancer risk (n = 3,189 cases) across levels of non‐modifiable risk factors were evaluated using proportional hazards regression. Mean adherence score was 5.0 points (range: 0.5–8.0). Higher adherence scores (score ≥6.0 vs. ≤3.5, HR = 0.76, 95% CI = 0.67–0.87), and adherence to the individual recommendations for body weight and alcohol intake were associated with a lower breast cancer incidence. While not statistically significant among women with more non‐modifiable risk factors (score ≥6.0 vs. ≤3.5, HR = 0.76, 95% CI = 0.36–1.63), hazard ratios were comparable to women with the no non‐modifiable risk factors (score ≥6.0 vs. ≤3.5, HR = 0.74, 95% CI = 0.49–0.93) (p‐interaction = 0.57). WCRF/AICR recommendation adherence is associated with lower breast cancer risk, regardless of non‐modifiable risk factor status.
Levels of Some Heavy Metals in Raw Cow's Milk from Selected Milk Production Sites in Iran: Is There any Health Concern?

Background: The aim of this study was to evaluate the content of mercury (Hg), arsenic (As), nickel (Ni) and tin (Sn) in raw cow’s milk of traditional and industrial sites from 8 different sites in Arak City, Markazi Province, Iran. Methods: In this cross sectional study, a total of 32 samples were collected from sub-cities of Arak, Iran via subjective sampling method. Both industrial and traditional dairy farms were selected for sampling. Twenty-five gram of each sample was turned to ash in ovens for metal analyses including Hg, As, Ni and Sn by anatomic absorption spectrometer. Results: The residue amounts of Hg and As were lower than permissible limit suggested by Codex Alimentarius, but for Ni and Sn it was higher only in one of the collection sites. The average concentration of Hg was significantly higher (P<0.05) in traditional farms as compared to industrial farms. Besides, amounts of Sn was significantly high in the traditional farms (P<0.05). Further, a high contents Ni was detected in industrial farms (P<0.05). Conclusion: High Sn and Ni contents of some milk samples from this region might be potentially hazardous to consumers. Further, none of the other metals tested crossed permissible levels.
A Structured Response to Misinformation: Defining and Annotating Credibility Indicators in News Articles

The proliferation of misinformation in online news and its amplification by platforms are a growing concern, leading to numerous efforts to improve the detection of and response to misinformation. Given the variety of approaches, collective agreement on the indicators that signify credible content could allow for greater collaboration and data-sharing across initiatives. In this paper, we present an initial set of indicators for article credibility defined by a diverse coalition of experts. These indicators originate from both within an article's text as well as from external sources or article metadata. As a proof-of-concept, we present a dataset of 40 articles of varying credibility annotated with our indicators by 6 trained annotators using specialized platforms. We discuss future steps including expanding annotation, broadening the set of indicators, and considering their use by platforms and the public, towards the development of interoperable standards for content credibility.
An Evaluation of Oral Midazolam for Anxiety and Pain in First-Trimester Surgical Abortion: A Randomized Controlled Trial

OBJECTIVE: To estimate the effect of oral midazolam on patient pain and anxiety perception during first-trimester surgical abortion. METHODS: Between May and December 2013, we conducted a randomized, double-blind, placebo-controlled trial. Patients between 6 0/7 and 10 6/7 weeks of gestation received 10 mg oral midazolam or placebo 30–60 minutes before surgical abortion. All patients received ibuprofen and a paracervical block. We powered the study (power=80%; significance level=.025) to detect a 15-mm difference in our two a priori primary outcomes of pain and anxiety with uterine aspiration on a 100-mm visual analog scale. Secondary outcomes were pain and anxiety at additional time points, memory, satisfaction, side effects, and adverse events. RESULTS: Demographics were similar between groups (placebo=62, midazolam=62). Compared with those randomized to placebo, patients who received midazolam had significantly less anxiety preoperatively (room entry: 51.4 mm compared with 34.5 mm, P<.001; positioning: 56.6 mm compared with 45.4 mm, P=.02). There was no difference in pain (P=.28) or anxiety (P=.14) during uterine aspiration or at other procedural time points. A significantly greater number of patients in the midazolam group reported partial amnesia (31/61 compared with 16/61, P=.005) and dizziness (30/61 compared with 18/61, P=.03). Controlling for baseline differences, patients who received midazolam reported more postoperative sleepiness (P<.001) and less postoperative nausea (P=.004). There was no difference in overall satisfaction (P=.88). CONCLUSION: Although oral midazolam reduces preprocedural anxiety, it does not reduce pain or anxiety with uterine aspiration during first-trimester surgical abortions. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, www.clinicaltrials. gov, NCT01830881. LEVEL OF EVIDENCE: I