Miracle-dz/UniFAR-FTUs huggingface dataset:
Fairness-Based Tasks for Assessing Children’s Perceptions of Food Quantities and Associations with Portion Selection

It is critical to develop ecologically valid experimental methods to assess consumers’ food-related behaviors. Ad libitum approaches are often used but may not be appropriate for studies with children or with products that are not typically consumed until the individual feels full. The current study presents novel methods to assess children’s size perception and portion preference for gummy candies. In the first study, 62 children (30 boys, 32 girls) aged 6 to 9 years completed two matching tasks: one using pictures on a computer screen, and a similar task where the products were physically manipulated. Results of the two matching tasks were correlated, demonstrating that a computer-based approach could be used to predict the factors influencing children’s perception of food amount: the number, size, and shape of pieces. In the second study, a portioning measure was developed to investigate whether the factors identified in the matching tasks were confirmed in a task that more closely represented portion selection in the real world. The effects observed in the matching tasks could not be replicated in the portioning task. The size of each item had no significant impact on the portion selection, suggesting that it may be possible to reduce the size of pieces in snacks where multiple pieces are typically consumed without negatively impacting perceived quantity in children, thus offering a promising strategy to nudge children toward choosing smaller portions.
Tagging relations to achieve complex search goals

Social search is having a flourishing success for its effectiveness in retrieving high quality information useful to achieve complex search goals. Surprisingly, the potential of the social paradigm at the basis of collaborative tagging in satisfying complex search intents has been unexplored so far. We propose an extended model of folksonomies that allows to compose and tag complex user-defined relations among items, users, and tags. We show that this model offers several means to fulfill complex search tasks that are hard to be achieved by other existing services. Furthermore, we support the validity of our approach through a data-driven analysis on Flickr photosets and we present an online portal that provides this new user experience.
HANDBOOK FOR THE GREAT08 CHALLENGE: AN IMAGE ANALYSIS COMPETITION FOR COSMOLOGICAL LENSING

The GRavitational lEnsing Accuracy Testing 2008 (GREAT08) Challenge focuses on a problem that is of crucial importance for future observations in cosmology. The shapes of distant galaxies can be used to determine the properties of dark energy and the nature of gravity, because light from those galaxies is bent by gravity from the intervening dark matter. The observed galaxy images appear distorted, although only slightly, and their shapes must be precisely disentangled from the effects of pixelisation, convolution and noise. The worldwide gravitational lensing community has made significant progress in techniques to measure these distortions via the Shear TEsting Program (STEP). Via STEP, we have run challenges within our own community, and come to recognise that this particular image analysis problem is ideally matched to experts in statistical inference, inverse problems and computational learning. Thus, in order to continue the progress seen in recent years, we are seeking an infusion of new ideas from these communities. This document details the GREAT08 Challenge for potential participants. Please visit www.great08challenge. info for the latest information.
G 0 / G 1 Cell Cycle Arrest and Activation of Caspases in Honokiol-mediated Growth Inhibition of Human Gastric Cancer Cells

− Honokiol, a naturally occurring neolignan mainly found in Magnolia species, has been shown to have the anti-angiogenic, anti-invasive and cancer chemopreventive activities, but the molecular mechanism of actions has not been fully elucidated yet. In the present study, we investigated the effect of honokiol on the growth inhibitory activity in cultured SNU-638 human gastric cancer cells. We found that honokiol exerted potent antiproliferative activity against SNU-638 cells. Honokiol also arrested the cell cycle progression at the G0/G1 phase and induced the apoptotic cell death in a concentration-dependent manner. The cell cycle arrest was well correlated with the downregulation of Rb, cyclin D1, cyclin A, cyclin E, and CDK4 expression, and the induction of cyclin-dependent kinase inhibitor p27. The increase of sub-G1 peak by honokiol was closely related to the induction of apoptosis, which was evidenced by the induction of DNA fragmentation, the cleavage of poly(ADPribose) polymerase, and the sequential activation of caspase cascade. These findings suggest the cell cycle arrest and induction of apoptosis might be one possible mechanism of actions for the anti-proliferative activity of honokiol in human gastric cancer cell.
Preliminary Outcomes Report for CO2 Laser Assisted Electric-Acoustic Cochlear Implantation.

OBJECTIVE Report on the safety/efficacy of a novel, carbon dioxide (CO2) laser-assisted protocol for hearing-preservation cochlear implantation (HPCI) and electric-acoustic stimulation (EAS). STUDY DESIGN Retrospective case review. SETTING Tertiary referral center. PATIENTS Adult patients meeting established criteria for HPCI and EAS. INTERVENTION Therapeutic/rehabilitative. A standardized protocol used CO2 laser to achieve meticulous hemostasis and perform cochleostomy was evaluated. MAIN OUTCOME MEASURES Audiometric assessments included low-tone pure tone average (LtPTA), consonant-nucleus-consonant (CNC), and AzBio scores. Primary outcomes were low-tone hearing-preservation (LtHP) and EAS usage rates. Secondary outcomes included change in LtPTA, outcomes durability, and the rate/onset/presentation of delayed hearing loss (DHL). Subset analyses stratified data by presenting LtPTA and surgeon experience. RESULTS Forty-seven patients and 52 ears were included. Mean follow-up was 20.7 ± 12.6 months. When adjusted for preoperative LtPTA less than 60 dB, the LtHP rate was 77%. This was significantly better than for patients with LtPTA more than 60 dB (24%; p < 0.0001). Outcomes were highly durable. EAS usage was excellent in those with LtPTA less than 60 dB (100%). Nine patients developed DHL. Three additional patients (25%) were successfully salvaged via steroids. Both CNC and AzBio scores improved significantly (p < 0.0001) at definitive testing. Speech-hearing scores did not differ significantly between patients using/not using EAS. The complication rate was 3.8%; none were caused by the laser. Surgeon experience was associated with significantly better outcomes. CONCLUSION Use of a CO2 laser-assisted HPCI protocol was safe and effective. Outcomes were consistent with contemporary literature reporting. Patient selection and surgeon experience both significantly impacted outcomes.
Fatty acid analogue N-arachidonoyl taurine restores function of IKs channels with diverse long QT mutations

About 300 loss-of-function mutations in the IKs channel have been identified in patients with Long QT syndrome and cardiac arrhythmia. How specific mutations cause arrhythmia is largely unknown and there are no approved IKs channel activators for treatment of these arrhythmias. We find that several Long QT syndrome-associated IKs channel mutations shift channel voltage dependence and accelerate channel closing. Voltage-clamp fluorometry experiments and kinetic modeling suggest that similar mutation-induced alterations in IKs channel currents may be caused by different molecular mechanisms. Finally, we find that the fatty acid analogue N-arachidonoyl taurine restores channel gating of many different mutant channels, even though the mutations are in different domains of the IKs channel and affect the channel by different molecular mechanisms. N-arachidonoyl taurine is therefore an interesting prototype compound that may inspire development of future IKs channel activators to treat Long QT syndrome caused by diverse IKs channel mutations. DOI: http://dx.doi. org/10.7554/eLife.20272. 001
Dens Invaginatus : History , Etiology , Classification , Clinical Feature Radiographic Feature , Histological Findings and Management

Dens invaginatus is a tooth malformation resulting from an infolding of the dental papilla at the time of tooth development. The deep infolding of enamel and dentin are seen in the affected tooth. Maxillary lateral incisors are commonly affected tooth and bilateral occurrence is rare. It shows a broad spectrum of morphologic variations and it usually results in pulpal necrosis. Root canal therapy may undergo severe problems due to its complex anatomy of teeth. This review addresses the etiology, clinical and radiographic features of taurodontism, its association with various anomalies, as well as important considerations in various areas of expertise dental treatments of such teeth.
Neighbourhood Effects on Youth Educational Achievement in the Netherlands: Can Effects Be Identified and Do They Vary by Student Background Characteristics?

Adding to the growing body of research examining neighbourhood effects in European contexts, this study investigates the associations between the educational achievement of Dutch youth and their neighbourhood conditions. We further consider whether these associations vary by student socioeconomic status (SES), gender, or nativity. Results from a multilevel analysis of 17 836 secondary school students living in 3085 neighbourhoods indicate significant relationships between several dimensions of the neighbourhood context and educational achievement. Student SES and nativity appear to moderate some of these effects. In particular, we find the negative effect of neighbourhood disadvantage to be almost entirely restricted to native youth. The achievement outcomes of students with higher levels of SES also appear to be less affected by neighbourhood affluence and disadvantage than those of lower-SES students. Our results suggest that the impact of neighbourhood conditions on certain groups of youth may be obscured in studies that measure average neighbourhood effects across all individuals. Future research which examines neighbourhood effects and mechanisms across subgroups of youth, and which examines the links between the neighbourhood, family, and school contexts, can help us to better determine the neighbourhood's role in youth education.
Fibroblast Growth Factor–23 and Cardiac Structure and Function

Background Fibroblast growth factor–23 (FGF‐23) is a phosphaturic factor previously associated with left ventricular hypertrophy and systolic dysfunction among individuals with chronic kidney disease. Whether FGF‐23 acts directly to induce left ventricular hypertrophy, potentially independent of its klotho coreceptor, remains uncertain. We investigated associations of FGF‐23 with cardiac structural abnormalities among individuals with a broad range of kidney function and explored potential biological mechanisms using cardiac magnetic resonance imaging and histology in klotho‐null mice, an established model of constitutively elevated FGF‐23. Methods and Results Among 887 participants with coronary artery disease in the Heart and Soul Study, FGF‐23 was modestly associated with worse left ventricular ejection fraction (−1.0% per standard deviation increase in lnFGF‐23; standard error, 0.4%), but was not associated with the overall prevalence of concentric hypertrophy (odds ratio, 1.5; CI, 0.9 to 2.4) or eccentric hypertrophy (odds ratio, 1.1; CI, 0.9 to 1.3). FGF‐23 was only associated with concentric hypertrophy among individuals with diminished kidney function (eGFR <60 mL/min per 1.73 m2; odds ratio, 2.3; CI, 1.0 to 5.3; P‐interaction=0.28). Comparing klotho‐null with wild‐type mice, null mice did not have greater left ventricular mass (P=0.37) or a lower ejection fraction (P=0.94). Conclusions Together, our results suggest that FGF‐23 is unlikely to have major effects on cardiovascular structure and function among patients free of substantial chronic kidney disease, and these effects may not be independent of the klotho coreceptor.
Impulsivity traits and addiction-related behaviors in youth

Background and aims Impulsivity is a risk factor for addictive behaviors. The UPPS-P impulsivity model has been associated with substance addiction and gambling disorder, but its role in other non-substance addiction-related behaviors is less understood. We sought to examine associations between UPPS-P impulsivity traits and indicators of multiple substance and non-substance addiction-related behaviors in youth with varying involvement in these behaviors. Methods Participants (N = 109, aged 16–26 years, 69% males) were selected from a national survey based on their level of externalizing problems to achieve a broad distribution of involvement in addiction-related behaviors. Participants completed the UPPS-P Questionnaire and standardized questionnaires assessing problematic use of substances (alcohol, cannabis, and other drugs) and non-substances (Internet gaming, pornography, and food). Regression analyses were used to assess associations between impulsivity traits and indicators of addiction-related behaviors. Results The UPPS-P model was positively associated with indicators of all addiction-related behaviors except problematic Internet gaming. In the fully adjusted models, sensation seeking and lack of perseverance were associated with problematic use of alcohol, urgency was associated with problematic use of cannabis, and lack of perseverance was associated with problematic use of other drugs than cannabis. Furthermore, urgency and lack of perseverance were associated with binge eating and lack of perseverance was associated with problematic use of pornography. Discussion and conclusions We emphasize the role of trait impulsivity across multiple addiction-related behaviors. Our findings in at-risk youth highlight urgency and lack of perseverance as potential predictors for the development of addictions and as potential preventative therapeutic targets.
A Method to Detect Differentially Methylated Loci With Next‐Generation Sequencing

Epigenetic changes, especially DNA methylation at CpG loci have important implications in cancer and other complex diseases. With the development of next‐generation sequencing (NGS), it is feasible to generate data to interrogate the difference in methylation status for genome‐wide loci using case‐control design. However, a proper and efficient statistical test is lacking. There are several challenges. First, unlike methylation experiments using microarrays, where there is one measure of methylation for one individual at a particular CpG site, here we have the counts of methylation allele and unmethylation allele for each individual. Second, due to the nature of sample preparation, the measured methylation reflects the methylation status of a mixture of cells involved in sample preparation. Therefore, the underlying distribution of the measured methylation level is unknown, and a robust test is more desirable than parametric approach. Third, currently NGS measures methylation at over 2 million CpG sites. Any statistical tests have to be computationally efficient in order to be applied to the NGS data. Taking these challenges into account, we propose a test for differential methylation based on clustered data analysis by modeling the methylation counts. We performed simulations to show that it is robust under several distributions for the measured methylation levels. It has good power and is computationally efficient. Finally, we apply the test to our NGS data on chronic lymphocytic leukemia. The results indicate that it is a promising and practical test.
Coherent oscillations inside a quantum manifold stabilized by dissipation

Manipulating the state of a logical quantum bit usually comes at the expense of exposing it to decoherence. Fault-tolerant quantum computing tackles this problem by manipulating quantum information within a stable manifold of a larger Hilbert space, whose symmetries restrict the number of independent errors. The remaining errors do not affect the quantum computation and are correctable after the fact. Here we implement the autonomous stabilization of an encoding manifold spanned by Schroedinger cat states in a superconducting cavity. We show Zeno-driven coherent oscillations between these states analogous to the Rabi rotation of a qubit protected against phase-flips. Such gates are compatible with quantum error correction and hence are crucial for fault-tolerant logical qubits.
Differences in Perceptions of the Food Environment Between African American Men Who Did and Did Not Consume Recommended Levels of Fruits and Vegetables

African American men have high rates of chronic disease morbidity and mortality associated with their low rates of fruit and vegetable consumption. In an effort to inform tailored behavioral interventions for this demographic, we sought to assess if men with healthier eating practices viewed their environment differently than those who ate less healthy. We segmented participants into high/low healthy eating categories based on the daily fruit and vegetable serving recommendations from the U.S. Department of Agriculture to determine if differences among environmental and social barriers were associated with different healthy eating patterns. We found key differences between men who consumed the recommended amount of fruits and vegetables (five or more servings/day, high healthy eating) and men who did not (low healthy eating). Men who consumed recommended levels of fruits and vegetables found eating healthy to be easy, and they described how they were able to overcome barriers such as the cost of healthy food, their limited knowledge of nutrition guidelines, and their lack of willpower to make healthier food choices. Men with healthier eating practices also identified individuals, plans, and resources they used or could use to help them have healthier eating practices. Conversely, men who were not eating recommended levels of fruits and vegetables also found eating healthy to be easy; however, they identified barriers limiting their access and did not articulate strategies to overcome these perceived barriers. Many of these men also indicated that they did not have social support to help them engage in healthier eating practices. These findings highlight the need to understand how African American men’s conceptualization of environmental resources and social supports relate to their eating practices.
MU-MIMO Communications With MIMO Radar: From Co-Existence to Joint Transmission

Beamforming techniques are proposed for a joint multi-input-multi-output (MIMO) radar-communication (RadCom) system, where a single device acts as radar and a communication base station (BS) by simultaneously communicating with downlink users and detecting radar targets. Two operational options are considered, where we first split the antennas into two groups, one for radar and the other for communication. Under this deployment, the radar signal is designed to fall into the null-space of the downlink channel. The communication beamformer is optimized such that the beampattern obtained matches the radar’s beampattern while satisfying the communication performance requirements. To reduce the optimizations’ constraints, we consider a second operational option, where all the antennas transmit a joint waveform that is shared by both radar and communications. In this case, we formulate an appropriate probing beampattern, while guaranteeing the performance of the downlink communications. By incorporating the SINR constraints into objective functions as penalty terms, we further simplify the original beamforming designs to weighted optimizations, and solve them by efficient manifold algorithms. Numerical results show that the shared deployment outperforms the separated case significantly, and the proposed weighted optimizations achieve a similar performance to the original optimizations, despite their significantly lower computational complexity.
A New Generative Statistical Model for Graphs: The Latent Order Logistic (LOLOG) Model

Full probability models are critical for the statistical modeling of complex networks, and yet there are few general, flexible and widely applicable generative methods. We propose a new family of probability models motivated by the idea of network growth, which we call the Latent Order Logistic (LOLOG) model. LOLOG is a fully general framework capable of describing any probability distribution over graph configurations, though not all distributions are easily expressible or estimable as a LOLOG. We develop inferential procedures based on Monte Carlo Method of Moments, Generalized Method of Moments and variational inference. To show the flexibility of the model framework, we show how so-called scale-free networks can be modeled as LOLOGs via preferential attachment. The advantages of LOLOG in terms of avoidance of degeneracy, ease of sampling, and model flexibility are illustrated. Connections with the popular Exponential-family Random Graph model (ERGM) are also explored, and we find that they are identical in the case of dyadic independence. Finally, we apply the model to a social network of collaboration within a corporate law firm, a friendship network among adolescent students, and the friendship relations in an online social network.
Survival of HIV-1 and HIV-2 perinatally infected children in The Gambia

Background: The risk of mother-to-child transmission (MTCT) of HIV-2 is much lower than that of HIV-1, but the long-term prognosis of perinatally infected HIV-2 children is unknown. We re-visited children who were part of a large MTCT study in The Gambia (conducted during 1993–1997), in order to compare the long-term survival of children perinatally infected with HIV-2 with that of seronegative and of HIV-1 infected children. Methods: Five to eight years’ follow-up of a cohort of children born to HIV-negative, HIV-1 positive, and HIV-2 positive mothers. Results: Seven hundred and seventy-four children were followed up for a median of 6.6 years. Of 17 perinatally HIV-1 infected children, three were still alive on 1 July 2001, two had been lost to follow-up, and 12 had died. The median survival was 2.5 years. Of eight HIV-2 infected children five were still alive, none were lost to follow-up and three had died. The mortality hazards ratio of both HIV-1 [9.9; 95% confidence interval (CI), 5.2–19], and of HIV-2 infected children (3.9; CI, 1.2–12) was significantly increased compared with children of seronegative mothers. The mortality hazards ratio of HIV uninfected children of HIV-1 or HIV-2 infected mothers was not significantly increased compared to that of children of seronegative mothers (P = 0.17 and P = 0.5 respectively). Conclusions: Children with perinatally acquired HIV-2 infection have a higher mortality than children of seronegative mothers. Guidelines for treatment of HIV-1 infected children should be used for treatment of HIV-2 infected children.