Miracle-dz/UniFAR-FTUs huggingface dataset:
Pathological Analysis of Local Delivery of Paclitaxel Via a Polymer-Coated Stent

Background— Paclitaxel can inhibit vascular smooth muscle proliferation in vitro, and early studies suggest that paclitaxel may be useful in preventing restenosis. Early and late intimal growth and local vascular pathological changes associated with paclitaxel delivered via stents have not been fully explored. Methods and Results— Localized drug delivery was accomplished with balloon-expandable stainless steel stents coated with a cross-linked biodegradable polymer, chondroitin sulfate and gelatin (CSG), containing various doses of paclitaxel. CSG-coated stents with paclitaxel (42.0, 20.2, 8.6, or 1.5 &mgr;g of paclitaxel per stent), CSG-coated stents without paclitaxel, and uncoated stents (without paclitaxel or CSG) were deployed in the iliac arteries of New Zealand White rabbits, which were killed 28 days after implant. Mean neointimal thickness at stent strut sites was reduced 49% (P <0.0003) and 36% (P <0.007) with stents containing 42.0 and 20.2 &mgr;g of paclitaxel per stent, respectively, versus CSG-coated stents without paclitaxel. However, histological findings suggested incomplete healing in the higher-dose (42.0 and 20.2 &mgr;g) paclitaxel-containing stents consisting of persistent intimal fibrin deposition, intraintimal hemorrhage, and increased intimal and adventitial inflammation. Stents coated with CSG alone (without paclitaxel) had similar neointimal growth as uncoated stents. In a separate group of rabbits killed at 90 days, neointimal growth was no longer suppressed by CSG-coated stents containing 42.0 or 21.0 &mgr;g of paclitaxel Conclusions— CSG coating appears to be a promising medium for localized drug delivery. Paclitaxel polymer–coated stents reduce neointima formation but are associated with evidence of incomplete healing at 28 days. However, neointimal suppression was not maintained at 90 days.
Junctional membrane inositol 1,4,5-trisphosphate receptor complex coordinates sensitization of the silent EGF-induced Ca2+ signaling

Ca2+ is a highly versatile intracellular signal that regulates many different cellular processes, and cells have developed mechanisms to have exquisite control over Ca2+ signaling. Epidermal growth factor (EGF), which fails to mobilize intracellular Ca2+ when administrated alone, becomes capable of evoking [Ca2+]i increase and exocytosis after bradykinin (BK) stimulation in chromaffin cells. Here, we provide evidence that this sensitization process is coordinated by a macromolecular signaling complex comprised of inositol 1,4,5-trisphosphate receptor type I (IP3R1), cAMP-dependent protein kinase (PKA), EGF receptor (EGFR), and an A-kinase anchoring protein, yotiao. The IP3R complex functions as a focal point to promote Ca2+ release in two ways: (1) it facilitates PKA-dependent phosphorylation of IP3R1 in response to BK-induced elevation of cAMP, and (2) it couples the plasmalemmal EGFR with IP3R1 at the Ca2+ store located juxtaposed to the plasma membrane. Our study illustrates how the junctional membrane IP3R complex connects different signaling pathways to define the fidelity and specificity of Ca2+ signaling.
Towards S matrices on flat space and pp waves from SYM

We analyze the possibility of extracting S matrices on pp waves and flat space from SYM correlators. For pp waves, there is a subtlety in defining S matrices, but we can certainly obtain observables. Only extremal correlators survive the pp wave limit. A first quantized string approach is inconclusive, producing in the simplest form results that vanish in the pp wave limit. We define a procedure to get S matrices from SYM correlators, both for flat space and for pp waves, generalizing a procedure due to Giddings. We analyze nonrenormalized correlators: 2 and 3 -point functions and extremal correlators. For the extremal 3-point function, the SYM and AdS results for the S matrix match for the angular dependence, but the energy dependence doesn't.
Film Mood and Its Quantitative Determinants in Different Types of Scenes

Films elicit emotions in viewers by infusing the story they tell with an affective character or tone—in a word, a mood. Considerable effort has been made recently to develop computational methods to estimate affective content in film. However, these efforts have focused almost exclusively on style-based features while neglecting to consider different scene types separately. In this study, we investigated the quantitative determinants of film mood across scenes classified by their setting and use of sounds. We examined whether viewers could assess film mood directly in terms of hedonic tone, energetic arousal, and tense arousal; whether their mood ratings differed by scene type; and how various narrative and stylistic film attributes as well as low- and high-level computational features related to the ratings. We found that the viewers were adept at assessing film mood, that sound-based scene classification brought out differences in the mood ratings, and that the low- and high-level features related to different mood dimensions. The study showed that computational film mood estimation can benefit from scene type classification and the use of both low- and high-level features. We have made our clip assessment and annotation data as well as the extracted computational features publicly available.
Analyst Coverage and the Cross Sectional Relation Between Returns and Volatility

The January effect conceals a significant negative relation between returns and idiosyn-cratic volatility at horizons up to two years. Controlling for January and the influence of penny stocks, we find that this relation, first documented by Ang, Hodrick, Xing and Zhang (2006), is robust to various measures of idiosyncratic volatility even after skipping a month to account for bid-ask reversals. The relation is not attributable to small firms or stocks with lottery-like payoffs. We model and empirically test the hypothesis that low returns to high volatility stocks are corrections of optimistic mispricing that arises because news shocks generate disagreement among traders. Our empirical tests, which use low analyst coverage as a proxy for disagreement, are consistent with this explanation of both AHXZ's result and the negative relation between returns and turnover volatility documented by Chordia, Subrahmanyam and Anshuman (2001). Among other findings, we show that the negative relations between returns and idiosyncratic volatility, and returns and turnover volatility, exist only among low coverage stocks.
Falls in Korean Polio Survivors: Incidence, Consequences, and Risk Factors

Falls and fall-related injuries are important issue among polio survivors. The purpose of this study was to determine the incidence of, and consequences and factors associated with falls among Korean polio survivors. A total of 317 polio survivors participated in this study. All participants completed a questionnaire including fall history, symptoms related to post-polio syndrome and other information through a telephone interview. Among them, 80 participants visited our clinic for additional physical measurements and tests. Of the 317 respondents, 68.5% reported at least one fall in the past year. Of the fallers, 42.5% experienced at least one fall during one month. Most falls occurred during ambulation (76.6%), outside (75.2%) and by slipping down (29.7%). Of fallers, 45% reported any injuries caused by falls, and 23.3% reported fractures specifically. Female sex, old age, low bone mineral density, the presence of symptoms related to post-polio syndrome (PPS), poor balance confidence, short physical performance battery and weak muscle strength of knee extensor were not significantly associated with falls. Only leg-length discrepancy using spine-malleolar distance (SMD) was a significant factor associated with falls among Korean polio survivors. Our findings suggest that malalignment between the paralytic and non-paralytic limb length should be addressed in polio survivors for preventing falls.
New coding method to reduce the database size and algorithm with significant efficiency in association rules

The problem of discovery association rules in large databases is considered. An encoding method for converting large databases to small one is proposed. Significant efficiency is obtained by applying some modified known algorithm on our proposed database layout. In addition, a new algorithm based on the proposed encoding method is introduced. Using some properties of numbers our database converts itemset to numerical domain. Our implementation indicates that the proposed layout made the size of database significantly smaller. Also the time to find association rules is reduced.
A Novel Scheduling Mechanism For Hybrid Cloud Systems

Large scale and complexity in structure are two major trends in current cloud environments. Bringing cloud computing to its full potential requires a paradigm shift toward cloud resiliency. A major challenge in designing resilient clouds is to avoid single point of failures in cloud management systems. The state-of-the-art cloud management systems are mostly designed by relying on centralized managing systems with complicated master nodes, which are prone to single point of failures. In this paper, we propose a novel resilient hybrid cloud management system to ensure offering consistent cloud services to users, which consists of two tiers: a peer-to-peer (P2P) tier and a centralized tier. In the centralized tier, each local cloud has a centralized management system, while these local clouds form a P2P cloud in the P2P tier. Our hybrid cloud system benefits from auto scaling across the entire system while it easily manages each local cloud. We propose an innovative user request scheduling mechanism, dedicated to our system, considering multi-objectives: minimizing user requests average makespan, while ensuring load balancing. Finally, we conduct extensive experiments to evaluate the performance of our proposed hybrid cloud management system.
The use of an automated cueing device to assist people with dementia during handwashing

A person who has dementia often has difficulty using the washroom independently, and requires constant assistance and supervision. This results in a loss of independence and privacy, and in hislher caregiver becoming stressed. These problems may be avoided by using an automated device that prompts and monitors the person as helshe completes a washroom task. A prototype of such a device was developed. A preliminary study was conducted, which determined whether a generic device could be used, or if the device needed to be personalized for each individual user. This study concluded that a device that incorporates descriptive generic cues would be as effective as one that incorporates personalized cues. An eficacy study was conducted with the developed device. This study found that the device was effective in assisting a subject with dementia to wash his hands more independently. An increase in his success rate was observed, and the "workload" of his caregiver was reduced.
The Choice of Majors as a Signaling Device

This work analyzes the ability signaling hypothesis using a rich set of data of a homogeneous population -Business and Economics graduates of University X- who share similar occupations in the labor market. After studying three years of a common core curriculum, students must choose between either a Business or an Economics major. The work investigates if the choice of major is employed by the labor market as a signal of ability and of expected productivity, and if this is reflected in differences in the earnings profiles of graduates of each field. Given the detailed nature of the data, we employ an unusually rich measure of ability, namely the grades obtained in the core curriculum. This work presents multiple evidence in favor of this hypothesis. The evidence is based on seven empirical results, properly derived from a simple theoretical signaling model. The empirical facts support the signaling hypothesis under the assumption that an individual's ability is gradually revealed to the labor market as experience increases.
Mapping the temporal evolution of scientific community structures

We present results from tracking the temporal evolution of community structures within a research specialty. This extends our previous work in which we generated static community maps that combine co-author networks and direct citation networks derived from 20-years of publications in the research specialty. Here, we explore how the temporal evolution of these maps can be used to provide insights into the historical evolution of a field as well as extract more accurate snapshots of the community structures at a given point in time. Such time resolved mappings are an important component in our mixed method approach that integrates network analysis with ethnographic field studies to investigate field-specific communication and collaboration behaviors in scientific communities (Velden & Lagoze 2013). Evaluating these maps in qualitative interviews with field experts will be the next step in our research.
in Cyberspace : Challenges for U . S . Law Enforcement

"Who did it? " Attribution, some may argue, is a challenge "as old as crime and punishment. " In the cyber realm too, criminal attribution is a key delineating factor between cybercrime and other threats. When investigating a given incident, law enforcement is challenged with tracing the action to its source and determining whether the actor is a criminal or whether the actor may be a terrorist or state actor posing a potentially greater national security threat.
On the Degrees of Freedom of the Symmetric Multi-Relay MIMO Y Channel

In this paper, we study the degrees of freedom (DoF) of the symmetric multi-relay multiple-input multiple-output Y channel, where three user nodes, each with <inline-formula> <tex-math notation="LaTeX">$M$ </tex-math></inline-formula> antennas, communicate via <inline-formula> <tex-math notation="LaTeX">$K$ </tex-math></inline-formula> geographically separated relay nodes, each with <inline-formula> <tex-math notation="LaTeX">$N$ </tex-math></inline-formula> antennas. For this model, we establish a general DoF achievability framework based on linear precoding and post-processing methods. The framework poses a nonlinear problem with respect to user precoders, user post-processors, and relay precoders. To solve this problem, we adopt an <italic>uplink–downlink asymmetric</italic> strategy, where the user precoders are designed for signal alignment and the user post-processors are used for interference neutralization. With the user precoder and post-processor designs fixed as such, the original problem then reduces to a problem of relay precoder design. To address the solvability of the system, we propose a general method for solving matrix equations. Together with the techniques of antenna disablement and symbol extension, an achievable DoF of the considered model is derived for an arbitrary setup of <inline-formula> <tex-math notation="LaTeX">$(K, M, N)$ </tex-math></inline-formula>. We show that for <inline-formula> <tex-math notation="LaTeX">$K\geq 2$ </tex-math></inline-formula>, the optimal DoF is achieved for <inline-formula> <tex-math notation="LaTeX">$({M}/{N}) \in [0,\max \{({\sqrt {3K}}/{3}),1\})\cup [(({3K+({9K^{2}-12K}})^{1/2})/{6}),\infty )$ </tex-math></inline-formula>. We also show that the uplink-downlink asymmetric design proposed in this paper considerably outperforms the conventional approach based on uplink-downlink symmetry.
Systematic Study of Particle Production at High p_T with the PHENIX Experiment

A systematic study of particle production at large transverse momentum with the PHENIX experiment at RHIC is shown. We demonstrate that the suppression of the yield of high p_T hadrons in central Au+Au collisions compared to the scaled p+p reference persists up to highest p_T for neutral pions and eta mesons. A similar suppression pattern is also observed in Cu+Cu collisions at the same energy. In addition we present the first RHIC results on high-p_T particle production close to SPS energies.
A fast subtraction algorithm of brain CT Angiography images based on MMBE

Based on the traditional Matched Mask Bone Elimination (MMBE) method, this paper presents an improved subtraction method of Brain Computer Tomography Angiography (CTA) images. The method can be divided into two main parts, registration and bone elimination algorithms. Firstly, based on three-dimensional mutual information registration algorithm, this paper adapted sample and compression of gray scales through stastical analysis of the volume data to decrease data account and improve the calculate speed of registration. Then in the bone elimination algorithm, the extraction of bone mask in CT images is implemented by the combination of threshold and refinement of bone mask We proposed a method to optimize the calculation strategies to decrease the cost of calculation. Through the analysis of the experiments on the clinical image data, the developed method proposed in this paper have improved about eight times of computing speed. The operation time of brain CT/CTA images with about two hundred slices has been limited in twenty seconds. And the main arteries can be displayed clearly in three-dimensional space.
Assessing the Effects of Dual Tasking on Spatiotemporal Parameters of Gait in Older Adults: Exploring Age and Task Demands

The percentage of the senior citizens is expected to be 20% of the US population by 2030. Falls are considered a global problem due to the increased rate of falls and the costs associated with treating impairments resulting from falls. To date, the effects of performing different types of dual tasks among different age groups of the elderly has received less attention. Therefore, this study sought to assess the impact on spatiotemporal parameters of gait when differing age groups of older adults performer dual tasks that require differing motor and cognitive demands. Three standard measurements were used in this study: (a) the Mini Mental State Examination, (b) Dynamic Gait Index, and (c) The Time Up and Go test. Thirty-one participants walked on (GAITRite) and randomly performed a total of three trials for each of the four tasks: (a) walking, (b) walking while calculating, (c) walking while stepping over an obstacle, and (d) walking while talking. The spatiotemporal parameters of gait — velocity, cadence, stride length, and double supports —were analyzed by using a mixed design analysis of variance (ANOVA). Furthermore, if the main effect within participants was significant, a pairwise comparison (Bonferroni correction) was used to determine where the difference lied. The results of this study showed a significant difference in the main effect for the age classification of stride length of the left leg. Furthermore, there were significant differences in the main effect for the single task and dual tasking of velocity, cadence, double support for left and right legs, and stride length for left and right leg. Additionally, there were significant differences in the main effect for the dual tasking of velocity, cadence, double support for left and right legs, and stride length for left and right leg. EFFECTS OF AGING AND TASKS 17 The observations showed that the elderly decreased velocity, cadence, and stride length while increasing double support when the complexity of dual tasking increased, in order to provide more stability. Additionally, this study made the elderly concentrate on their balance rather than on the task itself. Therefore, it is important that employees in senior housing be aware of this study when giving instructions to elderly people while they are walking, because the elderly will either concentrate on their walking or ignore the instructions, or they will follow the instructions and increase their rates of falling. EFFECTS OF AGING AND TASKS 18
Gauge/gravity duality with a chiral = (0, 8) string defect

We study the defect AdS/CFT correspondence for a system of Nc D3-branes intersecting certain configurations of D7-branes and O7-planes in 1+1-dimensions. The intersection is chiral, preserving = (0, 8) supersymmetry. The geometry produced by the 7-branes does not decouple in the low energy limit on the D3-branes; consequently the field theory must be considered in the curved background of the 7-branes, and the supergravity background is the fully backreacted solution accounting for both sets of branes. Although we can not work in the probe-brane limit, we still find a consistent defect mode-operator map. In our previous study of the field theory we found chiral D3-brane zero-modes that localized to the intersection. Here we obtain a dual supergravity description of the localized R-symmetry anomaly that these zero-modes produce.
Perceptions and actions: Combining privacy and risk perceptions to better understand user behaviour

Exploring the link between privacy and behaviour has been difficult, as many contextual and other variables lead to a schism between privacy attitudes and behaviour. We propose that one possible means forward is to consider risk perceptions as an important additional dimension when exploring individual differences in privacy concern. Using cluster analysis, we demonstrate the benefit of creating more multi-dimensional user profiles (=clusters) as these can provide a better inside into behaviour. These clusters were able to differentiate users based on both privacy and risk perceptions into users who were (a) highly concerned and risk-sensitive; (b) unconcerned but risk-aware; and (c) moderately concerned but less risk-aware cluster. Using these clusters, we were able to explain different patterns of self-reported behaviours related to technical and general caution. Further analysis of behaviours associated with the use of mobile devices, public networks and social networking in relation to these clusters did not result in any significant findings. We provide a number of topics for discussion and practical solutions that have yet to be implemented in order to better understand the link between privacy attitudes and behaviour.
Recent Discussion Papers from the ‘ Future of Trade Unions in Modern Britain ’ Programme Centre for Economic Performance 529

This paper estimates the size of the union membership wage premium by comparing wage outcomes for unionised workers with ‘matched’ non-unionised workers. The method assumes selection on observables. For this identifying assumption to be plausible, one must be able to control for all characteristics affecting both union status and wages. This requires very informative data. We illustrate the value of the rich data offered by the linked employer-employee Workplace Employee Relations Survey (WERS) 1998 in implementing this methodology. We estimate the union membership premium for the whole private sector, among workers in workplaces where at least some workers are covered by collective bargaining, and in occupations with pay set by collective bargaining. We find a raw 17-25% union premium in gross hourly wages for the private sector in Britain, depending on the subgroup used. However, post-matching this difference falls to between 3% and 6%. This indicates that the higher pay of unionised workers is largely accounted for by their better underlying earnings capacity, which is associated with their individual characteristics, the jobs they do and the workplaces they find themselves in.