Miracle-dz/UniFAR-FTUs huggingface dataset:
GlassHands: Interaction Around Unmodified Mobile Devices Using Sunglasses

We present a novel approach for extending the input space around unmodified mobile devices. Using built-in front-facing cameras of unmodified handheld devices, GlassHands estimates hand poses and gestures through reflections in sunglasses, ski goggles or visors. Thereby, GlassHands creates an enlarged input space, rivaling input reach on large touch displays. We introduce the idea along with its technical concept and implementation. We demonstrate the feasibility and potential of our proposed approach in several application scenarios, such as map browsing or drawing using a set of interaction techniques previously possible only with modified mobile devices or on large touch displays. Our research is backed up with a user study.
Combinatorial Effects of Alpha- and Gamma-Protocadherins on Neuronal Survival and Dendritic Self-Avoidance

The clustered protocadherins (Pcdhs) comprise 58 cadherin-related proteins encoded by three tandemly arrayed gene clusters, Pcdh-α, Pcdh-β, and Pcdh-γ (Pcdha, Pcdhb, and Pcdhg, respectively). Pcdh isoforms from different clusters are combinatorially expressed in neurons. They form multimers that interact homophilically and mediate a variety of developmental processes, including neuronal survival, synaptic maintenance, axonal tiling, and dendritic self-avoidance. Most studies have analyzed clusters individually. Here, we assessed functional interactions between Pcdha and Pcdhg clusters. To circumvent neonatal lethality associated with deletion of Pcdhgs, we used Crispr-Cas9 genome editing in mice to combine a constitutive Pcdha mutant allele with a conditional Pcdhg allele. We analyzed roles of Pcdhas and Pcdhgs in the retina and cerebellum from mice (both sexes) lacking one or both clusters. In retina, Pcdhgs are essential for survival of inner retinal neurons and dendritic self-avoidance of starburst amacrine cells, whereas Pcdhas are dispensable for both processes. Deletion of both Pcdha and Pcdhg clusters led to far more dramatic defects in survival and self-avoidance than Pcdhg deletion alone. Comparisons of an allelic series of mutants support the conclusion that Pcdhas and Pcdhgs function together in a dose-dependent and cell-type-specific manner to provide a critical threshold of Pcdh activity. In the cerebellum, Pcdhas and Pcdhgs also cooperate to mediate self-avoidance of Purkinje cell dendrites, with modest but significant defects in either single mutant and dramatic defects in the double mutant. Together, our results demonstrate complex patterns of redundancy between Pcdh clusters and the importance of Pcdh cluster diversity in postnatal CNS development. SIGNIFICANCE STATEMENT The formation of neural circuits requires diversification and combinatorial actions of cell surface proteins. Prominent among them are the clustered protocadherins (Pcdhs), a family of ∼60 neuronal recognition molecules. Pcdhs are encoded by three closely linked gene clusters called Pcdh-α, Pcdh-β, and Pcdh-γ. The Pcdhs mediate a variety of developmental processes, including neuronal survival, synaptic maintenance, and spatial patterning of axons and dendrites. Most studies to date have been limited to single clusters. Here, we used genome editing to assess interactions between Pcdh-α and Pcdh-γ gene clusters. We examined two regions of the CNS, the retina and cerebellum and show that the 14 α-Pcdhs and 22 γ-Pcdhs act synergistically to mediate neuronal survival and dendrite patterning.
For Whom the Mind Wanders, and When

An experience-sampling study of 124 undergraduates, pretested on complex memory-span tasks, examined the relation between working memory capacity (WMC) and the experience of mind wandering in daily life. Over 7 days, personal digital assistants signaled subjects eight times daily to report immediately whether their thoughts had wandered from their current activity, and to describe their psychological and physical context. WMC moderated the relation between mind wandering and activities' cognitive demand. During challenging activities requiring concentration and effort, higher-WMC subjects maintained on-task thoughts better, and mind-wandered less, than did lower-WMC subjects. The results were therefore consistent with theories of WMC emphasizing the role of executive attention and control processes in determining individual differences and their cognitive consequences.
Estimating Xylella fastidiosa transmission parameters: decoupling sharpshooter number and feeding period

Compared to human‐ and wildlife‐transmitted pathogens, less emphasis has been placed on developing models of plant pathogen transmission by insects. Here, we describe the transmission ecology of the bacterium Xylella fastidiosa Wells et al., the causal agent of Pierce’s disease in grapevines, by its leafhopper vectors. First, we performed a meta‐analysis of transmission studies of X. fastidiosa by its two most important vectors in the Western USA, the invasive glassy‐winged sharpshooter, Homalodisca vitripennis Germar, and the native blue‐green sharpshooter, Graphocephala atropunctata Signoret (both Hemiptera: Cicadellidae). The importance of vector number, pathogen acquisition period, and inoculation access period (IAP) for transmission differed between the two species. We fit these transmission datasets to two biologically derived transmission models, i.e., a binomial and a Poisson probability model. The Poisson model provided substantially better fit and produced estimates of H. vitripennis transmission efficiency that were dramatically lower than for G. atropunctata. We also conducted a separate pair of experiments that decoupled vector number from IAP. These experiments supported the results of the meta‐analysis. Interestingly, high vector loads not only increased transmission rate, but also shortened X. fastidiosa incubation period in grapevines. This work provides quantitative estimates of transmission of an economically important pathogen that is analogous to risk models for arthropod‐vectored human and wildlife diseases. In addition, this work suggests that heterogeneous vector loads may accelerate the disease cycle, increasing the potential for secondary spread in vineyards.
Medical Marijuana Laws Reduce Prescription Medication Use In Medicare Part D.

Legalization of medical marijuana has been one of the most controversial areas of state policy change over the past twenty years. However, little is known about whether medical marijuana is being used clinically to any significant degree. Using data on all prescriptions filled by Medicare Part D enrollees from 2010 to 2013, we found that the use of prescription drugs for which marijuana could serve as a clinical alternative fell significantly, once a medical marijuana law was implemented. National overall reductions in Medicare program and enrollee spending when states implemented medical marijuana laws were estimated to be $165.2 million per year in 2013. The availability of medical marijuana has a significant effect on prescribing patterns and spending in Medicare Part D.
Determination of silymarin flavonoids by HPLC and LC-MS and investigation of extraction rate of silymarin in Silybum marianum fruits by boiling water.

A method has been developed for simultaneous separation and determination of seven important silymarin flavonoids by HPLC and LC-ESI/MS. The separation was completed on an ODS column using 1 % aqueous acetic acid solution and methanol as mobile phase with gradient elution. The methanol is better than acetonitrile as the organic modifier in mobile phase for separation of diastereomers of silybin (silybin A and silybin B) and diastereomers of isosilybin (isosilybin A and isosilybin B) was explained from the viewpoint of molecules interaction. The content of silybin and silymarin in Silybum marianum seed, defatted seed meal and standardized extract were determined with satisfactory recovery and precision. Furthermore, the extraction rate of silymarin flavonoids in Silybum marianum seed with boiling water was evaluated on the basis of the well-verified quantitative method. It is found that more polar flavonoids such as taxifolin and silychristin have good solution in water and the total extraction rates of seven times were more than 85 %, and the solubility of other silymarin flavonoids is relatively low, but the total extraction rates were all more than 30 % for seven times of extraction. The results of this study are in excellent agreement with those of batch extraction with hot water.
MiR-433 functions as a tumor suppressor in glioma cells by regulating YAP 1

YAP1 is an oncogene in plenty types of tumors and miR-433 is a tumor suppressor in many types of tumors. Furthermore, YAP1 is overexpressed in glioma and the function mechanism is still not entirely clear. So this study was aimed to investigate whether YAP1 expression in glioma is associated with miRNA. The YAP1 expression in glioma tissues and glioma cells and miR-433 expression in glioma tissues were detected using real-time PCR. Then the relationship between YAP1 and miR-433 was analyzed by dual-luciferase assay. The effects of miR-433 overexpression on the proliferation, apoptosis, migration and invasion of glioma cells (LN382 and AM38) were evaluated using CCK-8 assay, flow cytometry, wound-healing assay and transwell assay, respectively. MiR-433 was lowly expressed in glioma tissues (P < 0.01) when YAP1 was highly expressed (P < 0.01), and miR-433 could directly target the YAP1 and indirectly downregulate the expression of YAP1. Overexpression of miR-433 would inhibit the proliferation, migration and invasion of glioma cells but promote the apoptosis of glioma cells. MiR-433 targets 3’UTR of YAP1 and may suppress the proliferation, migration and invasion of glioma cells through downregulating the YAP1 expression. This discovery is helping to understand the regulatory mechanism of YAP1 expression in glioma cells.
Microsatellite Polymorphism in the Heme Oxygenase-1 Gene Promoter and the Risk of Atrial Fibrillation in Taiwanese

Background Atrial fibrillation (AF) is associated with increased oxidative stress. Emerging evidence suggests that heme oxygenase-1 (HO-1) is a potent antioxidant system against various oxidative stress-related diseases. The human HO-1 promoter has a GT-repeat length polymorphism that can determine the level of gene transcription. Objective The aim of this study is to assess the role of the GT-repeat polymorphism in the promoter region of the HO-1 gene in Chinese-Taiwanese patients with AF. Methods and Results This study enrolled 200 AF patients and 240 controls, comparable for age and gender. In each subject, the length of GT-repeat polymorphism in the HO-1 promoter region was examined by polymerase chain reactions. The frequencies of long GT-repeat alleles (≧32) were significantly higher in AF patients than in controls. Multivariate analysis showed that the presence of long allele was significantly and independently associated with AF (odds ratio: 1.91, 95% CI 1.07–3.72; P = 0.028). Right atrial tissues from patients with chronic AF were investigated with immunoconfocal microscopy. Patients homozygous for shorter GT-repeat alleles exhibited greater HO-1 expression in their atria than those homozygous for longer alleles, which was reflected by less oxidative stress, myofibril degradation, and fibrosis in the atria of patients with shorter GT-repeat. In vitro, transient transfection assay in HL-1 atrial myocytes showed that the responsiveness of HO-1 transcriptional activity to tachypacing was inversely correlated with the length of the GT-repeats. Conclusion Our results suggest that the HO-1 microsatellite polymorphism may contribute to the genetic background of AF in Chinese-Taiwanese patients.
HPV vaccine acceptability in a rural Southern area.

BACKGROUND Although cervical cancer rates in the United States are highest in Southern and rural areas, research on human papillomavirus (HPV) vaccine acceptability has focused on other geographic areas. METHODS To address this gap, we surveyed women from a rural area in North Carolina with elevated rates of cervical cancer to identify predictors of HPV vaccine acceptability for themselves and their daughters. RESULTS One hundred forty-six women completed questionnaires about HPV infection, cervical cancer, and HPV vaccination. The majority (62%) of respondents were African American. Most respondents intended to vaccinate an adolescent daughter against HPV. Older and African American women reported lower vaccination intentions. Higher intentions to vaccinate an adolescent daughter against HPV were associated with knowing more about HPV, believing that HPV infection and cervical cancer are both likely and have negative consequences, and believing that the HPV vaccine is effective against cervical cancer. Women reported higher intentions to get the HPV vaccine for an adolescent daughter than for themselves. CONCLUSIONS HPV vaccine acceptability for an adolescent daughter was associated with women's beliefs about their own healthcare needs. These findings on the HPV vaccination decisions of women in North Carolina offer insights that can inform future health communication activities intended to increase vaccination uptake in other high-risk populations of rural Southern women.
Detectors for polarized skylight in insects: a survey of ommatidial specializations in the dorsal rim area of the compound eye

Apart from the sun, the polarization pattern of the sky offers insects a reference for visual compass orientation. Using behavioral experiments, it has been shown in a few insect species (field crickets, honey bees, desert ants, and house flies) that the detection of the oscillation plane of polarized skylight is mediated exclusively by a group of specialized ommatidia situated at the dorsal rim of the compound eye (dorsal rim area). The dorsal rim ommatidia of these species share a number physiological properties that make them especially suitable for polarization vision: each ommatidium contains two sets of homochromatic, strongly polarization‐sensitive photoreceptors with orthogonally‐arranged analyzer orientations. The physiological specialization of the dorsal rim area goes along with characteristic changes in ommatidial structure, providing actual anatomical hallmarks of polarized skylight detection, that are readily detectable in histological sections of compound eyes. The presence of anatomically specialized dorsal rim ommatidia in many other insect species belonging to a wide range of different orders indicates that polarized skylight detection is a common visual function in insects. However, fine‐structural disparities in the design of dorsal rim ommatidia of different insect groups indicate that polarization vision arose polyphyletically in the insects. Microsc. Res. Tech. 47:368–379, 1999. © 1999 Wiley‐Liss, Inc.
Access to Orphan Drugs: A Comprehensive Review of Legislations, Regulations and Policies in 35 Countries

Objective To review existing regulations and policies utilised by countries to enable patient access to orphan drugs. Methods A review of the literature (1998 to 2014) was performed to identify relevant, peer-reviewed articles. Using content analysis, we synthesised regulations and policies for access to orphan drugs by type and by country. Results Fifty seven articles and 35 countries were included in this review. Six broad categories of regulation and policy instruments were identified: national orphan drug policies, orphan drug designation, marketing authorization, incentives, marketing exclusivity, and pricing and reimbursement. The availability of orphan drugs depends on individual country’s legislation and regulations including national orphan drug policies, orphan drug designation, marketing authorization, marketing exclusivity and incentives such as tax credits to ensure research, development and marketing. The majority of countries (27/35) had in place orphan drug legislation. Access to orphan drugs depends on individual country’s pricing and reimbursement policies, which varied widely between countries. High prices and insufficient evidence often limit orphan drugs from meeting the traditional health technology assessment criteria, especially cost-effectiveness, which may influence access. Conclusions Overall many countries have implemented a combination of legislations, regulations and policies for orphan drugs in the last two decades. While these may enable the availability and access to orphan drugs, there are critical differences between countries in terms of range and types of legislations, regulations and policies implemented. Importantly, China and India, two of the largest countries by population size, both lack national legislation for orphan medicines and rare diseases, which could have substantial negative impacts on their patient populations with rare diseases.
Handwritten to Electronic Prescriptions:Emerging Views and Practices, Saudi Arabia

Background: There has been little research on electronic prescribing (EP) in Middle Eastern countries. This is in part due to the slow implementation of electronic health records [EHR] integrated with EP. Electronic prescribing is associated with a considerable reduction in medication errors compared to handwritten prescriptions. Objective: This paper reviews the relevant literature on handwritten and EP in the Kingdom of Saudi Arabia, as well as focusing on global issues including problems related to handwritten prescribing, the role of EP in mitigating these problems, the functions of the EHR system with EP, ways of implementing EP, and identifying potential barriers and challenges in the Middle Eastern region. Search Strategy: Computer searches of PubMed and Google Scholar were conducted using the keywords “handwritten prescription,” “pen and pencil prescription,” “medication prescribing,” “medication errors,” “electronic prescribing,” and “electronic medical records. ”
Adaptive risk bounds in unimodal regression

We study the statistical properties of the least squares estimator in unimodal sequence estimation. Although closely related to isotonic regression, unimodal regression has not been as extensively studied. We show that the unimodal least squares estimator is adaptive in the sense that the risk scales as a function of the number of values in the true underlying sequence. Such adaptivity properties have been shown for isotonic regression by Chatterjee et al(2015) and Bellec(2015). A technical complication in unimodal regression is the non-convexity of the underlying parameter space. We develop a general variational representation of the risk that holds whenever the parameter space can be expressed as a finite union of convex sets, using techniques that may be of interest in other settings.
The impact of EpCAM expression on response to chemotherapy and clinical outcomes in patients with epithelial ovarian cancer

Epithelial ovarian cancer is a highly lethal malignancy; moreover, overcoming chemoresistance is the major challenging in treating ovarian cancer patients. The cancer stem cell (CSC) hypothesis considers CSCs to be the main culprits in driving tumor initiation, metastasis, and resistance to conventional therapy. Although growing evidence suggest that CSCs are responsible for chemoresistance, the contribution of CSC marker EpCAM to resistance to chemotherapy remains unresolved. Here we have demonstrated that ovarian cancers containing high levels of EpCAM have a significantly much lower probability of achieving overall responsive rates after first-line chemotherapy. In addition, multivariate analysis revealed that EpCAM expression is an independent risk factor for chemoresistance, indicating that EpCAM expression is a predictive biomarker of chemotherapeutic response. Consistent with these clinical observations, in vitro assays, we found that the subpopulation of EpCAM-positive ovarian cancer cells shows a significantly higher viability compared with EpCAM-negative cells in response to cisplatin treatment by preventing chemotherapy-induced apoptosis, which is regulated by EpCAM-Bcl-2 axis. Furthermore, in an in vivo mouse model, platinum agents preferentially eliminated EpCAM-negative cells in comparison with EpCAM-positive cells, suggesting that the remaining subpopulation of EpCAM-positive cells contributes to tumor recurrence after chemotherapy. Finally, we also found that an increased expression of EpCAM is associated with poor prognosis in ovarian cancer patients. Our findings highlight the clinical significance of EpCAM in the resistance to chemotherapy and provide a rationale for EpCAM-targeted therapy to improve chemoresistance. Targeting EpCAM should be a promising approach to effectively extirpate the CSCs as the putative root of ovarian cancer.
Global maize production, utilization, and consumption

Maize (Zea mays), also called corn, is believed to have originated in central Mexico 7000 years ago from a wild grass, and Native Americans transformed maize into a better source of food. Maize contains approximately 72% starch, 10% protein, and 4% fat, supplying an energy density of 365 Kcal/100 g and is grown throughout the world, with the United States, China, and Brazil being the top three maize‐producing countries in the world, producing approximately 563 of the 717 million metric tons/year. Maize can be processed into a variety of food and industrial products, including starch, sweeteners, oil, beverages, glue, industrial alcohol, and fuel ethanol. In the last 10 years, the use of maize for fuel production significantly increased, accounting for approximately 40% of the maize production in the United States. As the ethanol industry absorbs a larger share of the maize crop, higher prices for maize will intensify demand competition and could affect maize prices for animal and human consumption. Low production costs, along with the high consumption of maize flour and cornmeal, especially where micronutrient deficiencies are common public health problems, make this food staple an ideal food vehicle for fortification.
Oriented cellulose films and fibers from a mesophase system

Cellulose mesophases were obtained by preparing concentrated solutions of cellulose (20–55%) in a mixture of N-methyl-morpholine N-oxide (MMNO) and water. The anisotropy depends on four interconnected parameters: the temperature of the solution which, in general, must be lower than 90°C; the concentration of cellulose which must exceed 20%; a water content such that the mole ratio water/anhydrous MMNO is smaller than unity; and the degree of polymerization of the dissolved cellulose. The anisotropic cellulose solutions can readily be oriented during extrusion or casting thus giving fibers or films which upon regeneration exhibit high orientation.
Signaling within Allosteric Machines: Signal Transmission Pathways Inside G Protein-Coupled Receptors

In recent years, our understanding of function of G protein-coupled receptors (GPCRs) has changed from a picture of simple signal relays, transmitting only a particular signal to a particular G protein heterotrimer, to versatile machines, capable of various responses to different stimuli and being modulated by various factors. Some recent reports provide not only the data on ligands/modulators and resultant signals induced by them, but also deeper insights into exact pathways of signal migration and mechanisms of signal transmission through receptor structure. Combination of these computational and experimental data sheds more light on underlying mechanisms of signal transmission and signaling bias in GPCRs. In this review we focus on available clues on allosteric pathways responsible for complex signal processing within GPCRs structures, with particular emphasis on linking compatible in silico- and in vitro-derived data on the most probable allosteric connections.