Miracle-dz/UniFAR-FTUs huggingface dataset:
The first six-month clinical outcomes and risk factors associated with high on-treatment platelet reactivity of clopidogrel in patients undergoing coronary interventions

Objective: This study attempted to fill the gaps in evidence related to response to clopidogrel treatment in the Turkish population. The study aimed to determine the prevalence, associated risk factors, and clinical outcomes of high on-treatment platelet reactivity (HTPR) of clopidogrel in patients undergoing percutaneous coronary intervention (PCI) in a tertiary cardiovascular hospital in Turkey. Methods: In this prospective studied a total of 1.238 patients undergoing PCI were included in the present study. Blood samples were analyzed using a Multiplate analyzer. All patients were examined in the outpatient clinics at the end of the first and sixth months for recording drug therapy compliance and study endpoints. Results: Among the study population, 324 (30.2%) patients were found to have HTPR (mean age 58.03±11.88 years, 71.7% men). The incidence of HTPR was higher amongst females than amongst males (38.3% vs. 27%, p=0.010). Hypertension and diabetes mellitus were more frequently observed in the HTPR group (57.7% vs. 48.7%, p=0.004; 35% vs. 29.1%, p=0.040, respectively). When the recorded data were analyzed using multinomial regression analysis, hypertension, hemoglobin level, platelet, lymphocyte, and eosinophil count were independently associated with HTPR. Conclusion: On the basis of the results obtained from our study, we conclude that 30.2% of the Turkish population has HTPR. Our results also led us to believe that hypertension is an associated risk factor and decreased hemoglobin level as well as increased platelet counts are laboratory parameters that are strongly associated with the presence of HTPR. However, no differences were observed with regard to cardiovascular mortality and stent thrombosis. (Anatol J Cardiol 2016; 16: 967-73)
EBMT for SMT : A New EBMT-SMT Hybrid

We propose a new framework for the hybridisation of Example-Based and Statistical Machine Translation (EBMT and SMT) systems. We add new functionality to Moses to allow it to work effectively with an EBMT system. Within this framework, we investigate the use of two types of EBMT system. The first uses string-based matching, and we investigate several variations, but find that the hybrid system is unable to match the pure SMT system. The second is a syntax-based EBMT system which uses dependency trees to compare inputs to the example base, and we show that this system is consistently better than the string-based approach. We find that, while the SMT system still performs better overall, the syntax-based hybrid does perform particularly well for some examples.
The Semiology of Motor Disorders in Autism Spectrum Disorders as Highlighted from a Standardized Neuro-Psychomotor Assessment

Background: Altered motor performance has been described in Autism Spectrum Disorders (ASD) with disturbances in walking; posture, coordination, or arm movements, but some individuals with ASD show no impairment of motor skills. The neuro-developmental processes that underpin the performance of neuro-psychomotor functions have not been widely explored, nor is it clear whether there are neuro-psychomotor functions specifically affected in ASD. Our objective was to focus on the semiology of motor disorders among children with ASD using a neuro-developmental assessment tool. Method: Thirty-four children with ASD, with or without intellectual deficit (ID) were recruited in a child psychiatry department and Autism Resource Centers. Initial standard evaluations for diagnosis (psychiatric; psychological; psychomotor) were supplemented by a standardized assessment battery for neuro-developmental psychomotor functions (NP-MOT). Results: The results of some NP-MOT tests differed between children with ASD with ID and those without. However, on the NP-MOT battery, neither of the two groups did well in the bi-manual and finger praxia tests (36 and 52% respectively failed). Manual and digital gnosopraxia showed some deficit (63 and 62% respectively failed). Postural deficits were found in tests for both static equilibrium (64%) and dynamic (52%). There were also difficulties in coordination between the upper and lower limbs in 58% of children. We found 75% failure in motor skills on the M-ABC test. Concerning muscular tone, significant laxity was observed in distal parts of the body (feet and hands), but hypertonia was observed in the proximal muscles of the lower limbs (reduced heel-ear angle). Discussion: The results of manual and digital gnosopraxia tests point to a planning deficit in children with autism. A gesture programming deficit is also highlighted by the poor results in manual praxis, and by failures in the M-ABC tests despite prior training of the child. However, concerning global motor function, a significant difference was observed between children with and without ID. Our findings suggest a semiology of tone deregulation between proximal versus distal muscles, indeterminate tonic laterality, postural control deficit (proprioceptive), impairment of inter-hemispheric coordination (corpus callosum), and neurological soft signs such asdysdiadochokinesia, which leads us to hypothesize a general impairment of motor functions.
Translational Mini‐Review Series on Vaccines: Monitoring of human papillomavirus vaccination

Persistent infection with oncogenic human papillomavirus (HPV) is a necessary cause of cervical cancer. Moreover, HPV type 16 (and to a lesser degree HPV type 18) is linked with more rare cancers, namely cancer of the vulva, vagina, penis, anus, oropharynx and larynx. Effective prophylactic vaccines have been developed. In this review, we briefly address immunological aspects of HPV infection and the results of HPV vaccination trials. Internationally standardized monitoring and evaluation of prophylactic HPV vaccination programmes will be essential for arriving at the most (cost‐)effective strategies for cancer control.
Wives' Experience of Husbands' Pornography Use and Concomitant Deception as an Attachment Threat in the Adult Pair-Bond Relationship

Evidence is growing that pornography use can negatively impact attachment trust in the adult pair-bond relationship. We employed a qualitative methodology to understand attachment implications of a partner's pornography use and concomitant deception. A qualitative analytic team analyzed interviews of 14 women in attachment-idealizing pair-bond relationships in couple therapy for their partner's pornography use. Analyses uncovered three attachment-related impacts from husbands' pornography use and deception: (1) the development of an attachment fault line in the relationship, stemming from perceived attachment infidelity; (2) followed by a widening attachment rift arising from wives' sense of distance and disconnection from their husbands; (3) culminating in attachment estrangement from a sense of being emotionally and psychologically unsafe in the relationship. Overall, wives reported global mistrust indicative of attachment breakdown. Building on this data, we build an attachment-informed model of effects of pornography use and concomitant deception in the pair-bond relationship.
Phenology and New County Records of Odonata of Northeastern Oklahoma

We summarize status, seasonality, and distribution of 69 species (plus three hypotheticals) of damselflies and dragonflies recorded in Osage, Tulsa, and Washington Counties, Oklahoma. To the 28 species listed in Abbott (2005) for this tricounty area, we add 45 species, including 27 new species for Osage, 54 for Tulsa, and 39 for Washington. These additions bring the county totals to 55, 55, and 40 species, respectively. We also present phenologies for all species that are common or uncommon in this area and for a few that occur rarely but with a distinct seasonality. Provided they continue to be gathered, detailed phenological data may prove helpful for monitoring predicted effects of global climate change.
Seagrass biofilm communities at a naturally CO2-rich vent

Seagrass meadows are a crucial component of tropical marine reef ecosystems. Seagrass plants are colonized by a multitude of epiphytic organisms that contribute to broadening the ecological role of seagrasses. To better understand how environmental changes like ocean acidification might affect epiphytic assemblages, the microbial community composition of the epiphytic biofilm of Enhalus acroides was investigated at a natural CO2 vent in Papua New Guinea using molecular fingerprinting and next-generation sequencing of 16S and 18S rRNA genes. Both bacterial and eukaryotic epiphytes formed distinct communities at the CO2-impacted site compared with the control site. This site-related CO2 effect was also visible in the succession pattern of microbial epiphytes. We further found an increased relative sequence abundance of bacterial types associated with coral diseases at the CO2-impacted site (Fusobacteria, Thalassomonas), whereas eukaryotes such as certain crustose coralline algae commonly related to healthy reefs were less diverse. These trends in the epiphytic community of E. acroides suggest a potential role of seagrasses as vectors of coral pathogens and may support previous predictions of a decrease in reef health and prevalence of diseases under future ocean acidification scenarios.
Role of Ubiquilin Associated with Protein-disulfide Isomerase in the Endoplasmic Reticulum in Stress-induced Apoptotic Cell Death*

Up-regulation of several stress proteins such as heat-shock proteins and glucose-regulated proteins participate in tolerance against environmental stress. Previously, we found that protein-disulfide isomerase (PDI) is specifically up-regulated in response to hypoxia/brain ischemia in astrocytes. In addition, the overexpression of this gene into neurons protects against apoptotic cell death induced by hypoxia/brain ischemia. To address the detailed function of PDI, we screened for proteins that interact with PDI using the yeast two-hybrid system. We report here that PDI interacts with ubiquilin, which has a ubiquitin-like domain and a ubiquitin-associated domain. Interestingly, ubiquilin is also up-regulated in response to hypoxia in glial cells with a time course similar to that of PDI induction. In hypoxia-treated glial cells, the endogenous ubiquilin and PDI were almost completely co-localized, suggesting that ubiquilin is an endoplasmic reticulum-associated protein. Overexpression of this gene in neuronal cells resulted in significant inhibition of the DNA fragmentation triggered by hypoxia, but not that induced by nitric oxide or staurosporine. Moreover, ubiquilin has the ability to attenuate CHOP induction by hypoxia. These observations suggested that ubiquilin together with PDI have critical functions as regulatory proteins for CHOP-mediated cell death, and therefore up-regulation of these proteins may result in acquisition of tolerance against ischemic stress in glial cells.
Are proprioceptive functions affected in Duchenne muscular dystrophy?

populations. They can, however, reassure us that the AIMS hasn’t changed and results from the AIMS should be utilized as they have been in the past. The authors stress appropriate caution in interpreting the AIMS related to developmental windows, cut-off points, and other history. Serendipitously, their methodology is well described and could be readily replicated with alternate populations, work that might contribute additional information on the big questions of motor development.
Planning and housing: concepts, policy instruments and market analysis

Since the 1980s, international commentators have debated extensively the impact of neoliberal reform agendas that have sought both to reduce the influence of planning and to make policies and practices more responsive to market processes. This reform agenda has been particularly evident in the context of planning for housing, where in many countries the clamour for greater deregulation of land and housing markets continues apace. For example, in the UK the Coalition Government appointed a Planning Minister in September 2012 who had openly revealed that not only did he see little value in planning, but by extension provided considerable evidence that he appears to accept – as do his colleagues in government – that the planning system merely prevents the market from delivering economic growth. As Nick Boles commented in 2010:
Does Twitter Trigger Bursts in Signature Collections?

Introduction The quantification of social media impacts on societal and political events is a difficult undertaking. The Japanese Society of Oriental Medicine started a signature-collecting campaign to oppose a medical policy of the Government Revitalization Unit to exclude a traditional Japanese medicine, “Kampo,” from the public insurance system. The signature count showed a series of aberrant bursts from November 26 to 29, 2009. In the same interval, the number of messages on Twitter including the keywords “Signature” and “Kampo,” increased abruptly. Moreover, the number of messages on an Internet forum that discussed the policy and called for signatures showed a train of spikes. Methods and Findings In order to estimate the contributions of social media, we developed a statistical model with state-space modeling framework that distinguishes the contributions of multiple social media in time-series of collected public opinions. We applied the model to the time-series of signature counts of the campaign and quantified contributions of two social media, i.e., Twitter and an Internet forum, by the estimation. We found that a considerable portion (78%) of the signatures was affected from either of the social media throughout the campaign and the Twitter effect (26%) was smaller than the Forum effect (52%) in total, although Twitter probably triggered the initial two bursts of signatures. Comparisons of the estimated profiles of the both effects suggested distinctions between the social media in terms of sustainable impact of messages or tweets. Twitter shows messages on various topics on a time-line; newer messages push out older ones. Twitter may diminish the impact of messages that are tweeted intermittently. Conclusions The quantification of social media impacts is beneficial to better understand people’s tendency and may promote developing strategies to engage public opinions effectively. Our proposed method is a promising tool to explore information hidden in social phenomena.
An efficient Encryption scheme based on Block Cipher Algorithms

Encryption algorithms play a main role in information security systems: It is the primary technique for data and communication security. Many encryption methods have been put forward to satisfy various applications. From the ancient times, the two fields of cryptology; cryptography and cryptanalysis are developing side by side. Cryptography studies the design of algorithms for information and communication security. In the other hand cryptanalysis is concerned with the study of different techniques to search weakness in the cryptographic algorithms and try to break them. That’s why the developed designs or ciphers should be secured against any possible attack in an ideal situation, but this is not possible in the practical world. Any cryptographic primitive can only be tested for all the possible known attacks however it can’t predict the future attacks that may be based on the weakness of the algorithm itself. Our main goal is to provide solutions for existing encryption algorithms which necessarily has its advantages and drawbacks. We must satisfy performs metrics of the application targets and performs metrics of the encryption algorithm. These performs include security, implementation parameters and hardware performances. Two solutions can be proposed: designing a new algorithms or adding update functions to existing algorithms. To specify the correct update function we must know the power of each attack and predict its capacities on the algorithm. The designed algorithm should keep all the advantages that present the main algorithm while adding solutions to the disadvantages essentially the security issues. Key-Words: Symmetric cryptography, block cipher, AES, Chaos, Hardware performance analysis, Security analysis, cryptanalysis, attacks, update function, operating modes, update functions.
Maori and Pacific Islander overrepresentation in the Australian criminal justice system—what are the determinants?

ABSTRACT Maori and Pacific Islanders are heavily overrepresented in the Australian criminal justice system. Despite these circumstances, little is known about the risk factors uniquely underpinning their involvement in criminal behavior. A review of the literature discovered that acculturation stressors, widespread educational disengagement, family and cultural disintegration, job insecurity, economic disadvantage, and social service inaccessibility were prevalent issues among both young Maori and Pacific Islander offenders and their communities. The findings signal the need for culturally tailored interventions that divert young Maori and Pacific Islanders from law-breaking behaviors while reconnecting them with family, culture, education, employment, and prosocial activities. Local efforts to address this significant gap in service delivery have been made and are discussed within.
DO DIFFERENT MATHEMATICAL OPERATIONS INVOLVE DIFFERENT COMPONENTS OF THE WORKING MEMORY MODEL

Studies looking at the connections between working memory and chi ldren’s mathematical achievement are often limited by the general nature of the measures of either working memory or mathematics. In this study, thirty-five children in Year 5 (9 to 10 years of age) were given tasks designed to measure their phonological working memory, visual working memory, inhibitory skills and their mastery of addition and multiplication facts. The findings suggest that different components of the working memory model (Baddeley and Hitch, 1974; Baddeley, 1996) may be involved in these two different mathematical operations. WORKING MEMORY AND CHILDREN’S MATHEMATICS Working memory is a limited-capacity m ulti-component cognitive system responsible for the concurrent processing and storage of information in cognitive tasks. The current model comprises four components: a phonological loop responsible for the storage and rehearsal of speech based and phonological information, a visual-spatial sketchpad responsible for visual and spatial information and a central executive responsible for regulating the contents of working memory and integrating information from long-term memory. A fourth component, the episodic buffer, is responsible for combining information held in different forms into an integrated whole for a short time. In studies looking at the connections between children’s worki ng memory and mathematical performance, various components of the Baddeley and Hitch (1974) working memory model have been implicated. These include the central executive in general (Lehto, 1995), the phonological loop and central executive (Logie et al, 1994), phonological loop and visuo-spatial sketchpad (McKenzie, Bull, & Gray, 2003), central executive and visuo-spatial sketchpad (D'Amico and Guarnera, 2005) and visuo-spatial working memory (Reuhkala, 2001). One reason for this apparent lack of consensus in the literature may be the use of general measures of mathematics that could obscure links between working memory and specific mathematical operations. Another possible confounding factor could be the use of single measures of working memory that do not discriminate sufficiently between the different components of the model and therefore obscure potential connections.
Plasmon Hybridization in Clusters of Metal Nanoparticles and Magnetic Nanoparticle Oligomers

Plasmon Hybridization in Clusters of Metal Nanoparticles and Magnetic Nanoparticle Oligomers Nicholas P. Montoni Chair of the Supervisory Committee: Associate Professor David J. Masiello Department of Chemistry As the field of plasmonics develops, new knobs to turn and levers to pull become available to researchers. From the morphology and material composition of individual nanoparticles to background environments tunable in real time to aggregation scheme and spatial arrangement, many avenues for controllably altering the optical properties of metal nanoclusters are being explored. In this dissertation, we will focus on the latter; more specifically, the impact of metal nanocluster geometry on the collective plasmon behavior. It will be shown that complicated nanoparticle geometries can be modeled qualitatively as small nanoclusters of simpler shapes and that the introduction of asymmetry into a nanocluster can noticeably alter the nanocluster’s plasmonic behavior. We will also study the impact of nanocluster size and shape by investigating the dynamic spectral ordering of the collective plasmon modes of cyclic or hexagonally-packed nanoclusters. The purpose of this dissertation is to demonstrate theoretical methods for quantifying collective behavior in metal nanoclusters, and show the utility of the simple coupled dipole model for this purpose.
Characterization of the 8-Kilodalton Antigens of Taenia solium Metacestodes and Evaluation of Their Use in an Enzyme-Linked Immunosorbent Assay for Serodiagnosis

ABSTRACT The Western blot for cysticercosis, which uses lentil lectin purified glycoprotein (LLGP) antigens extracted from the metacestode of Taenia solium, has been the “gold standard” serodiagnostic assay since it was first described in 1989. We report that the diagnostic antigens at 14, 18, and 21 kDa, as well as some larger disulfide-bonded antigens, are actually all members of a very closely related family of proteins, the 8-kDa antigens. The genes for 18 unique, mature proteins have been identified. Nine of these were chemically synthesized and tested in an enzyme-linked immunosorbent assay with a battery of defined serum samples, including 32 cysticercosis-positive serum samples reactive with the 8-kDa antigens of LLGP on Western blotting, 34 serum samples from patients with other parasitic infections, and 15 normal human serum samples. One of the 8-kDa antigens, TsRS1, is 100% sensitive and 100% specific. TsRS1 will be one component of a cocktail of three to four synthetic or recombinant antigens, based on the diagnostic bands of the Western blot, which will be used for the serodiagnosis of cysticercosis.
Selection against Line-1 Retrotransposons Results Principally from Their Ability to Mediate Ectopic Recombination

LINE-1 (L1) retrotransposons constitute the most successful family of autonomous retroelements in mammals and they represent at least 17% of the size of the human genome. L1 insertions have occasionally been recruited to perform a beneficial function but the vast majority of L1 inserts are either neutral or deleterious. The basis for the deleterious effect of L1 remains a matter of debate and three possible mechanisms have been suggested: the direct effect of L1 inserts on gene activity, genetic rearrangements caused by L1-mediated ectopic recombination, or the retrotransposition process per se. We performed a genome-wide analysis of the distribution of L1 retrotransposons relative to the local recombination rate and the age and length of the elements. The proportion of L1 elements that are longer than 1.2 Kb is higher in low-recombining regions of the genome than in regions with a high recombination rate, but the genomic distributions of full-length elements (i.e. elements capable of retrotransposition) and long truncated elements were indistinguishable. We also found that the intensity of selection against long elements is proportional to the replicative success of L1 families. This suggests that the deleterious effect of L1 elements results principally from their ability to mediate ectopic recombination.