Miracle-dz/UniFAR-FTUs huggingface dataset:
Shrimp Oil-Enriched Mayonnaise Prepared Using Fish Myofibrillar Protein as a Substitute for Egg Yolk: Physical, Rheological, and Sensory Properties

The effect of SO (shrimp oil) at various levels (5, 10, and 15%) on the stability of mayonnaise was investigated. Droplet size (d32 and d43), polydispersity index, and microstructure results showed an upsurge in droplet sizes with augmenting level of SO in mayonnaise (5 to 15%) (p < 0.05). SO imparted a bright orange color to the mayonnaise as evidenced by increased a* and b* values with lower L* values (p < 0.05). Moreover, the impact of a fish myofibrillar protein (FMP) substitution for egg yolk (0, 25, 50, 75%) in mayonnaise containing SO (5% and 10%) was also studied. Increasing the level of FMP substitution in SO-added mayonnaise showed a dilution effect and reduced a* and b* values (p < 0.05). In addition, excessive FMP substitution up to 75% drastically increased centrifugal and thermal creaming indices, indicating lowered stability (p < 0.05). Nevertheless, with the augmenting FMP substitutions, the viscosity, texture, and rheological properties in mayonnaise became lower (p < 0.05). However, there were no differences in overall acceptability scores between 5% SO-added mayonnaise with 25% FMP substitution (SO5:FMP25) and 5% SO-added mayonnaise without FMP substitution (SO5:FMP0) (p > 0.05). A confocal laser scanning microscopic (CLSM) study revealed a smaller droplet and less aggregation in the SO5:FMP0 sample, compared to SO5:FMP25. The incorporation of SO and FMP substitution yielded the resulting mayonnaise, which met the requirements of a healthy food since SO is rich in PUFA and the replacement of egg yolk by FMP can contribute several health benefits. The incorporation of SO as well as FMP as substitution for egg yolk therefore has potential in the development of functional foods.
Human herpesvirus 8 seropositivity and risk of Kaposi's sarcoma and other acquired immunodeficiency syndrome-related diseases.

BACKGROUND The incidence of Kaposi's sarcoma (KS) is increased severalfold in individuals infected with human immunodeficiency virus-1 (HIV). Human herpesvirus 8 (HHV8) has also been implicated in KS. We investigated several factors that may determine the onset of KS, particularly HHV8 infection in individuals after becoming seropositive for HIV. METHODS We studied 366 individuals belonging to different HIV-exposure categories (i.e., homosexual activity, intravenous drug use, and heterosexual contact) for whom a negative HIV serologic test and then a positive HIV serologic test were available within a 2-year period. HHV8 antibody testing was performed by use of an immunofluorescence assay on the first serum sample available after the first positive HIV test. Actuarial rates of progression of KS and of other acquired immunodeficiency syndrome (AIDS)-defining diseases were estimated by use of time-to-event statistical methods. All statistical tests were two-sided. RESULTS Twenty-one of the 366 study participants developed AIDS-related KS, and 83 developed AIDS without KS. One hundred forty (38.3%) participants had detectable anti-HHV8 antibodies. The actuarial progression rate to KS among persons co-infected with HIV/HHV8 was nearly 30% by 10 years after HIV seroconversion. Increasing HHV8 antibody titers increased the risk of developing KS (for seronegative versus highest titer [1:125 serum dilution], adjusted relative hazard [RH] = 51.82; 95% confidence interval [CI] = 6.08-441.33) but not of other AIDS-defining diseases (adjusted RH = 1.14; 95% CI = 0.72-1.80). HHV8-seropositive homosexual men compared with HHV8-seropositive participants from other HIV-exposure categories showed an increased risk of KS that approached statistical significance (adjusted RH = 6.93; 95% CI = 0.88-54.84). CONCLUSIONS Approximately one third of individuals co-infected with HIV/HHV8 developed KS within 10 years after HIV seroconversion. Progression to KS increased with time after HIV seroconversion. Higher antibody titers to HHV8 appear to be related to faster progression to KS but not to other AIDS-defining diseases.
Duration of Cardiopulmonary Resuscitation and Illness Category Impact Survival and Neurologic Outcomes for In-hospital Pediatric Cardiac Arrests

Background— Pediatric cardiopulmonary resuscitation (CPR) for >20 minutes has been considered futile after pediatric in-hospital cardiac arrests. This concept has recently been questioned, although the effect of CPR duration on outcomes has not recently been described. Our objective was to determine the relationship between CPR duration and outcomes after pediatric in-hospital cardiac arrests. Methods and Results— We examined the effect of CPR duration for pediatric in-hospital cardiac arrests from the Get With The Guidelines–Resuscitation prospective, multicenter registry of in-hospital cardiac arrests. We included 3419 children from 328 US and Canadian Get With The Guidelines–Resuscitation sites with an in-hospital cardiac arrest between January 2000 and December 2009. Patients were stratified into 5 patient illness categories: surgical cardiac, medical cardiac, general medical, general surgical, and trauma. Survival to discharge was 27.9%, but only 19.0% of all cardiac arrest patients had favorable neurological outcomes. Between 1 and 15 minutes of CPR, survival decreased linearly by 2.1% per minute, and rates of favorable neurological outcome decreased by 1.2% per minute. Adjusted probability of survival was 41% for CPR duration of 1 to 15 minutes and 12% for >35 minutes. Among survivors, favorable neurological outcome occurred in 70% undergoing <15 minutes of CPR and 60% undergoing CPR >35 minutes. Compared with general medical patients, surgical cardiac patients had the highest adjusted odds ratios for survival and favorable neurological outcomes, 2.5 (95% confidence interval, 1.8–3.4) and 2.7 (95% confidence interval, 2.0–3.9), respectively. Conclusions— CPR duration was independently associated with survival to hospital discharge and neurological outcome. Among survivors, neurological outcome was favorable for the majority of patients. Performing CPR for >20 minutes is not futile in some patient illness categories.
Temporal Variability and Predictors of Urinary Bisphenol A Concentrations in Men and Women

Background Bisphenol A (BPA) is used to manufacture polymeric materials, such as polycarbonate plastics, and is found in a variety of consumer products. Recent data show widespread BPA exposure among the U.S. population. Objective Our goal in the present study was to determine the temporal variability and predictors of BPA exposure. Methods We measured urinary concentrations of BPA among male and female patients from the Massachusetts General Hospital Fertility Center. Results Between 2004 and 2006, 217 urine samples were collected from 82 subjects: 45 women (145 samples) and 37 men (72 samples). Of these, 24 women and men were partners and contributed 42 pairs of samples collected on the same day. Ten women became pregnant during the follow-up period. Among the 217 urine samples, the median BPA concentration was 1.20 μg/L, ranging from below the limit of detection (0.4 μg/L) to 42.6 μg/L. Age, body mass index, and sex were not significant predictors of urinary BPA concentrations. BPA urinary concentrations among pregnant women were 26% higher (–26%, +115%) than those among the same women when not pregnant (p > 0.05). The urinary BPA concentrations of the female and male partner on the same day were correlated (r = 0.36; p = 0.02). The sensitivity of classifying a subject in the highest tertile using a single urine sample was 0.64. Conclusion We found a nonsignificant increase in urinary BPA concentrations in women while pregnant compared with nonpregnant samples from the same women. Samples collected from partners on the same day were correlated, suggesting shared sources of exposure. Finally, a single urine sample showed moderate sensitivity for predicting a subject’s tertile categorization.
UNC5H4-induced apoptosis in non-small cell lung cancer is not dependent on p53 status only

The aim of the present study was to investigate the expression profile and prognostic significance of uncoordinated 5 homolog 4 (UNC5H4) in patients with lung cancer and to evaluate whether UNC5H4 expression may serve as an index for radiosensitivity. UNC5H4 and p53 expression levels were detected by immunohistochemistry, apoptosis was determined by a terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay and caspase 3 activation was determined by western blotting. The results showed that UNC5H4 expression was largely located in the membrane of the normal bronchial epithelium, but absent in the membranous regions or ectopic cytoplasm of 80/130 (61.5%) non-small cell lung cancer (NSCLC) tissue samples. Abnormal UNC5H4 expression was demonstrated to correlate with the degree of differentiation (P=0.015), TNM staging (P=0.037). Cytoplasmic UNC5H4 expression was shown to correlate negatively with p53 mutant type (mt) expression (r=−0.270; P=0.002) and positively with the apoptotic index (r=0.254; P=0.004). The statistical analyses indicated that the prognosis of patients with normal UNC5H4 expression was improved compared with that of patients with abnormal UNC5H4 expression, however, no significant difference was identified (P=0.125). Exposure of NSCLC tissue samples to X-radiation increased UNC5H4 expression and caspase 3 activity significantly, irrespective of p53 mutation status. In conclusion, these results indicate that X-rays induce apoptosis via the p53 pathway, and when this pathway is compromised, an additional pathway is utilized.
Survivability of Soil and Permafrost Microbial Communities after Irradiation with Accelerated Electrons under Simulated Martian and Open Space Conditions

One of the prior current astrobiological tasks is revealing the limits of microbial resistance to extraterrestrial conditions. Much attention is paid to ionizing radiation, since it can prevent the preservation and spread of life outside the Earth. The aim of this research was to study the impact of accelerated electrons (~1 MeV) as component of space radiation on microbial communities in their natural habitat—the arid soil and ancient permafrost, and also on the pure bacterial cultures that were isolated from these ecotopes. The irradiation was carried out at low pressure (~0.01 Torr) and low temperature (−130 °C) to simulate the conditions of Mars or outer space. High doses of 10 kGy and 100 kGy were used to assess the effect of dose accumulation in inactive and hypometabolic cells, depending on environmental conditions under long-term irradiation estimated on a geological time scale. It was shown that irradiation with accelerated electrons in the applied doses did not sterilize native samples from Earth extreme habitats. The data obtained suggests that viable Earth-like microorganisms can be preserved in the anabiotic state for at least 1.3 and 20 million years in the regolith of modern Mars in the shallow subsurface layer and at a 5 m depth, respectively. In addition, the results of the study indicate the possibility of maintaining terrestrial like life in the ice of Europa at a 10 cm depth for at least ~170 years or for at least 400 thousand years in open space within meteorites. It is established that bacteria in natural habitat has a much higher resistance to in situ irradiation with accelerated electrons when compared to their stability in pure isolated cultures. Thanks to the protective properties of the heterophase environment and the interaction between microbial populations even radiosensitive microorganisms as members of the native microbial communities are able to withstand very high doses of ionizing radiation.
A Novel Model of HVDC Hybrid-Type Superconducting Circuit Breaker and Its Performance Analysis for Limiting and Breaking DC Fault Currents

The key obstacle in integrating high-voltage direct current (HVDC) point-to-point networks into meshed multiterminal HVDC networks (MTDC) is the absence of dc circuit breakers (DCCBs), which can timely and reliably isolate the faulty HVDC network from the MTDC. In this paper, a novel hybrid-type superconducting DCCB model (SDCCB) is proposed. The SDCCB has a superconducting fault current limiter (SFCL) located in the main line, to limit the fault current until the final trip signal to the SDCCB is given. After the trip signal, insulated-gate bipolar transistor (IGBT) switches located in the main line will commutate the fault current into a parallel line, where dc current is forced to zero by combination of IGBTs and surge arresters. DC fault current behavior in MTDC and fundamental requirements of DCCB for MTDC were described, followed by an explanation of the working principles of the SDCCB. To prove the viability of the SDCCB, a simulation analysis demonstrating SDCCB current interruption performance was done for changing the intensity of dc fault current. It was observed that the passive current limiting by SFCL caused significant reduction in fault current interruption stress for SDCCB. Furthermore, fundamental design requirements for SFCL, including the effect of SFCL quenching impedance on SFCL voltage rating and energy dissipation capacity, were investigated. Finally, advantages and limitations of the SDCCB were highlighted.
5G Indoor Positioning Error Correction Based on 5G-PECNN

With the development of the mobile network communication industry, 5G has been widely used in the consumer market, and the application of 5G technology for indoor positioning has emerged. Like most indoor positioning techniques, the propagation of 5G signals in indoor spaces is affected by noise, multipath propagation interference, installation errors, and other factors, leading to errors in 5G indoor positioning. This paper aims to address these issues by first constructing a 5G indoor positioning dataset and analyzing the characteristics of 5G positioning errors. Subsequently, we propose a 5G Positioning Error Correction Neural Network (5G-PECNN) based on neural networks. This network employs a multi-level fusion network structure designed to adapt to the error characteristics of 5G through adaptive gradient descent. Experimental validation demonstrates that the algorithm proposed in this paper achieves superior error correction within the error region, significantly outperforming traditional neural networks.
Frequency compensation in two stage operational amplifier using common gate stage

This paper represents a highly stable, more efficient and low power CMOS based operational amplifier. A compensation strategy using common gate stage is used which provides high gain-bandwidth product and overcomes the drawback of source follower and lead compensation approaches by eliminating the complex poles and right-half-plane (RHP) zero. The proposed circuit utilized the miller capacitance in conjunction with common gate current buffer to obtain the design equations. This circuit is simulated at 45nm technology using cadence analog virtuoso tool. The operational amplifier designed here produces an improved unity gain frequency of 6.8 MHZ with phase margin of approximately 68° and an open loop gain of 88 dB which ensures the stability of the system. The stability is required in high frequency switching regulators like sampled data system to generate their power supplies. These can also be used in a so many analog circuits such as active filters, analog-to-digital converters, low-dropout regulators (LDOs).
Chronic immobilization stress occludes in vivo cortical activation in an animal model of panic induced by carbon dioxide inhalation

Breathing high concentrations of carbon dioxide (CO2) can trigger panic and anxiety in humans. CO2 inhalation has been hypothesized to activate neural systems similar to those underlying fear learning, especially those involving the amygdala. Amygdala activity is also upregulated by stress. Recently, however, a separate pathway has been proposed for interoceptive panic and anxiety signals, as patients exhibited CO2-inhalation induced panic responses despite bilateral lesions of the amygdala. This paradoxical observation has raised the possibility that cortical circuits may underlie these responses. We sought to examine these divergent models by comparing in vivo brain activation in unstressed and chronically-stressed rats breathing CO2. Regional cerebral blood flow measurements using functional Magnetic Resonance Imaging (fMRI) in lightly-anaesthetized rats showed especially strong activation of the somatosensory cortex by CO2 inhalation in the unstressed group. Strikingly, prior exposure to chronic stress occluded this effect on cortical activity. This lends support to recent clinical observations and highlights the importance of looking beyond the traditional focus on limbic structures, such as the hippocampus and amygdala, to investigate a role for cortical areas in panic and anxiety in humans.
Selenoprotein R Protects Human Lens Epithelial Cells against d-Galactose-Induced Apoptosis by Regulating Oxidative Stress and Endoplasmic Reticulum Stress

Selenium is an essential micronutrient for humans. Much of selenium’s beneficial influence on health is attributed to its presence within 25 selenoproteins. Selenoprotein R (SelR), known as methionine sulfoxide reductase B1 (MsrB1), is a selenium-dependent enzyme that, like other Msrs, is required for lens cell viability. In order to investigate the roles of SelR in protecting human lens epithelial (hLE) cells against damage, the influences of SelR gene knockdown on d-galactose-induced apoptosis in hLE cells were studied. The results showed that both d-galactose and SelR gene knockdown by siRNA independently induced oxidative stress. When SelR-gene-silenced hLE cells were exposed to d-galactose, glucose-regulated protein 78 (GRP78) protein level was further increased, mitochondrial membrane potential was significantly decreased and accompanied by a release of mitochondrial cytochrome c. At the same time, the apoptosis cells percentage and the caspase-3 activity were visibly elevated in hLE cells. These results suggested that SelR might protect hLE cell mitochondria and mitigating apoptosis in hLE cells against oxidative stress and endoplasmic reticulum (ER) stress induced by d-galactose, implying that selenium as a micronutrient may play important roles in hLE cells.
American Journal of Epidemiology Original Contribution Association of Childhood Obesity with Maternal Exposure to Ambient Air Polycyclic Aromatic Hydrocarbons during Pregnancy

There are concerns that prenatal exposure to endocrine-disrupting chemicals increases children's risk of obesity. mothers underwent personal air monitoring for polycyclic aromatic hydrocarbon (PAH) exposure during pregnancy, were followed up to ages 5 (n ¼ 422) and 7 (n ¼ 341) years. At age 5 years, 21% of the children were obese, as were 25% of those followed to age 7 years. After adjustment for child's sex, age at measurement, ethnicity, and birth weight and maternal receipt of public assistance and prepregnancy obesity, higher prenatal PAH exposures were significantly associated with higher childhood body size. In adjusted analyses, compared with children of mothers in the lowest tertile of PAH exposure, children of mothers in the highest exposure tertile had a 0.39-unit higher body mass index z score (95% confidence interval (CI): 0.08, 0.70) and a relative risk of 1.79 (95% CI: 1.09, 2.96) for obesity at age 5 years, and they had a 0.30-unit higher body mass index z score (95% CI: 0.01, 0.59), a 1.93-unit higher percentage of body fat (95% CI: 0.33, 3.54), and a relative risk of 2.26 (95% CI: 1.28, 4.00) for obesity at age 7 years. The data indicate that prenatal exposure to PAHs is associated with obesity in childhood. Childhood obesity clearly has multiple causes, with the literature identifying proximal, individual-level behavioral risk factors (e.g., high-fat diets, sedentary behavior) and more distal societal-level risk factors affecting diet and physical activity (e.g., suburbanization, automobile dependence, and agricultural policies) (1–3). However, a provocative emerging hypothesis is that exposure to environmental endocrine disruptors plays a role in the obesity epidemic by altering metabolic programming in early life (4–10). The polycyclic aromatic hydrocarbons (PAHs) are a family of chemicals created during incomplete combustion processes and are known human carcinogens that also have endocrine-disrupting effects (11–13). Hydroxy-PAHs, in particular , are structurally similar to estrogen and have been shown to have estrogenic activity in T47D breast adenoma cell lines (ER-CALUX assay; BioDetection Systems, Amsterdam, the Netherlands) (14). Likewise, PAH-containing particulate air pollution has been shown to be estrogenic in the T47D cell line and BG1Luc4E2 ovarian carcinoma cell line and in yeast (14–17). Recent murine and human adipocyte cell culture experiments showed that treatment with benzo[a]pyrene, a model PAH, inhibits lipolysis, and recent mouse studies found that benzo[a]pyrene exposure caused gains in fat mass (18). In the Columbia Center for Children's Environmental Health birth cohort study, the Mothers and …
Characterization of an anion‐permeable channel from sugar beet vacuoles: effect of inhibitors

The vacuole occupies 25‐95% of the plant cell volume and plays an essential role in maintaining cytoplasmic homeostasis of nutrients and ions. Recent patch‐clamp studies identified ion channels and electrogenic pumps as pathways for the movement of ions and metabolites across the vacuolar membrane (tonoplast). At high cytoplasmic Ca2+ (>10‐6 M) and negative potentials (inside the vacuole) non‐selective channels of the ‘slow‐vacuolar (SV)‐type’ were activated resulting in anion release or cation influx. In the present study these vacuolar channels were characterized pharmacologically by ion channel inhibitors. The cation‐transport inhibitors Ba2+, TEA+ and amiloride caused only partial and reversible block of the ‘SV‐type’channels, whereas anion‐transport inhibitors strongly affected the vacuolar channels. Pyridoxalphosphate and the dimethylaminecarboxylate derivates anthracene‐9‐carboxylic acid and C 144 reversibly blocked the channels up to 70% and Zncl2 up to 95%. DIDS and SITS inhibited this channel irreversibly up to 95%. The block developed under a variety of experimental conditions using solutions containing combinations of permanent cations and anions. The DIDS binding site is located on the cytoplasmic surface of the tonoplast, as intravacuolar DIDS did not block the channels. DIDS concentrations in the micromolar range, efficient in blocking 70—80% of the ‘SV‐type’ channels did not significantly affect ATP‐induced or pyrophosphate‐induced proton‐pumps. Stilbene derivatives may therefore be useful tools for studies on the substrate binding site on this vacuolar channel and for channel isolation.
A 80-MHz-to-410-MHz 16-Phases DLL Based on Improved Dead-Zone Open-Loop Phase Detector and Reduced-Gain Charge Pump

In this paper, a low jitter 16-phases delay locked loop (DLL) is proposed based on a simple and sensitive phase detector (PD). Dead-zone of the proposed PD is improved in compare to the conventional structures where the pulse generator postpones PD response and reduces the sensitivity. Also, the conventional structure of charge pumps is modified to inject small charge throughout the continuous outputs of PD. Smaller bias current is provided in charge pump via subtracting tail currents of intentionally mismatched differential pairs. Duty cycle of output differential phases is adjusted to around 50% using common mode setting strategy on delay elements. Simulation results confirm that DLL loop can provide 16-phases in frequency range of 80 to 410 MHz, consuming total power of 3.5 and 5.6 mW, respectively. The dead-zone of PD is also reduced from 80 to 14 ps when the pulse generator section is eliminated. Also, RMS jitter of about 45 and 1.76 ps are obtained at 80 and 410 MHz, respectively, when the supply voltage is subject to around 40 mV peak-to-peak noise disturbances. The proposed DLL can be implemented in less than 0.05 mm2 active area in a 0.18 μm CMOS technology.