Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of Wind Farm Power Oscillations on the Irish Power System

The impact of power fluctuations arising from fixed-speed wind turbines on the magnitude and frequency of inter-area oscillations has been investigated. The authors introduced data acquisition equipment to record the power flow on the interconnector between the Northern Ireland and Republic of Ireland systems. Through monitoring the interconnector oscillation using a fast Fourier transform, it was possible to determine the magnitude and frequency of the inter-area oscillation between the two systems. The impact of tower shadow on the output power from a wind farm was analysed using data recorded on site. A case study investigates the effect on the system of the removal of a large fixed-speed wind farm. Conclusions are drawn on the impact that conventional generation and the output from fixed-speed wind farms have on the stability of the Irish power system.
Arginine-rich Peptides

A basic peptide derived from human immunodeficiency virus (HIV)-1 Tat protein (positions 48–60) has been reported to have the ability to translocate through the cell membranes and accumulate in the nucleus, the characteristics of which are utilized for the delivery of exogenous proteins into cells. Based on the fluorescence microscopic observations of mouse macrophage RAW264.7 cells, we found that various arginine-rich peptides have a translocation activity very similar to Tat-(48–60). These included such peptides as the d-amino acid- and arginine-substituted Tat-(48–60), the RNA-binding peptides derived from virus proteins, such as HIV-1 Rev, and flock house virus coat proteins, and the DNA binding segments of leucine zipper proteins, such as cancer-related proteins c-Fos and c-Jun, and the yeast transcription factor GCN4. These segments have no specific primary and secondary structures in common except that they have several arginine residues in the sequences. Moreover, these peptides were able to be internalized even at 4 °C. These results strongly suggested the possible existence of a common internalization mechanism ubiquitous to arginine-rich peptides, which is not explained by a typical endocytosis. Using (Arg) n (n = 4–16) peptides, we also demonstrated that there would be an optimal number of arginine residues (n ∼ 8) for the efficient translocation.
Optimal Pricing Strategies for Open Source Support Providers *

The market for commercial open source software (OSS) has been rapidly growing with the proliferation of OSS. One way to commercialize OSS is the support model, which has been adopted by leading OSS firms such as Red Hat and JBoss. Despite the growing interest in OSS commercialization, little research has provided OSS support providers with a pricing guideline. In this paper, we examine the optimal pricing strategies for OSS support providers. Our benchmark is a monopoly case in which we investigate a startup software vendor’s incentive to choose the OSS support regime over the proprietary one. Then we extend the model to a duopoly case in which OSS under the support regime competes against proprietary software. We characterize the conditions under which the OSS support model is viable under competition. We believe that our results offer insights to the OSS vendors who consider commercializing their OSS with a support model.
[A study of attitudes toward illness and its effect on mortality in patients with Parkinson's disease].

The standardized mortality ratio (SMR), i.e. the ratio of observed to expected deaths, was investigated among 433 patients with Parkinson's disease (172 males and 261 females), who had been visited by public health nurses for a period of more than one year between 1978 and 1987 in Osaka Prefecture. The mean age of the patients was 58.7, and the average duration of the disease was 6.1 years at study entry. The follow-up period averaged 4.1 years during which sixty eight deaths were observed. The SMR of the patients was 2.54 relative to the general population of Osaka Prefecture. The SMR of those who were able to walk without assistance at study entry was 1.73, while that of patients with severe gait disturbance was 3.81. Patients were divided into three groups according to the extent of daily physical exercise performed to maintain their remaining function. Among patients who had been able to walk, those doing daily physical exercise showed the lowest SMR of 1.46. Among those with severe gait disturbance, the SMR of the exercising group was also the lowest at 1.72. These results indicate that daily physical exercise affects the mortality of Parkinsonian patients independently of the grade of disability. Participation in daily exercise was strongly influenced by the patient's will to battle his illness, and was significantly related to the presence of a spouse, economic situation of household, and the number of rooms in their dwelling.
Laminar Flow with Slip in Channels with Uniformly Porous Walls

The assumption of no slip does not accurately characterize momentum transfer near permeable walls. The influence of nonzero slip velocities on velocity profiles, pressure distribution, and friction coefficient are reported for laminar flow in a parallel plate channel with uniform suction or injection through its porous boundaries. The 2‐D Navier‐Stokes equations are reduced to a third‐order, nonlinear, ordinary differential equation with one free parameter by introducing an appropriate stream function that is then solved numerically. This solution is valid for arbitrary values of the wall Reynolds number Rw, based on the half‐channel height and the suction wall velocity. Suction at the porous boundary appears to have a greater impact on fluid mechanics compared to injection. It is observed that at a fixed value of the slip coefficient, increasing suction results in thinner momentum boundary layers whereas for a fixed wall Reynolds number, velocity profiles approach plug flow with increasing slip. It is al.
Single air-hole ring polygonal photonic crystal fibers with reduced bending loss and field distortion

In the present paper large mode area polygonal photonic crystal fibers with a single air-hole ring, which can be exploited for high-power fiber laser applications, have been studied. A new design that structures the air-holes in a single ring, according to a polygonal symmetry, around a solid core has been proposed. Octagonal and decagonal symmetries have been considered to design fibers less affected by the penalties arising in bending conditions, in particular the loss and the guided mode field distortion. The bending properties of different fibers with an effective area of 1400 mum2, confinement loss lower than 0.3 dB/m for the fundamental mode, and about 1 dB/m for the first higher order one at 1064 nm, have been analyzed and compared. Simulation results have shown that the mode distortion, evaluated through an overlap factor on a circular core region, as well as the loss value, can be reduced when considering photonic crystal fibers with a decagonal symmetry.
A Multi Scale Cognitive Architecture to Account for the Adaptive and Reflective Nature of Behaviour

We present a multi-agent cognitive architecture in which reactive and sequential processes can dynamically influence each other to insure that behaviour is responsive to current context (behavioural and situational) while sensitive to the longer term behavioural sequences needed to solve complex problems. We present the implementation of such a system using an agent based approach and illustrate its processing trough the simulation of two psychological tasks.
Robust ASR based on clean speech models: an evaluation of missing data techniques for connected digit recognition in noise

In this study, techniques for classification with missing or unreliable data are applied to the problem of noise-robustness in Automatic Speech Recognition (ASR). The techniques described make minimal assumptions about any noise background and rely instead on what is known about clean speech. A system is evaluated using the Aurora 2 connected digit recognition task. Using models trained on clean speech we obtain a 65% relative improvement over the Aurora clean training baseline system, a performance comparable with the Aurora baseline for multicondition training.
Phase II study with oxaliplatin and S-1 for patients with metastatic colorectal cancer.

BACKGROUND To evaluate the efficacy and safety of the combination of oxaliplatin and S-1 (OS) in treating metastatic colorectal cancer. PATIENTS AND METHODS Eligible patients were those with measurable lesions, no previous history of chemotherapy (except adjuvant chemotherapy), an age of 18-70 years, and an Eastern Cooperative Oncology Group performance status of zero to two. Oxaliplatin 130 mg/m(2) was administered i.v. on day 1, and S-1 40 mg/m(2) b.i. d. was administered orally on days 1-14, every 3 weeks. RESULTS Forty-eight patients (median age, 56 years) were enrolled: 23 had colon cancer, seven rectosigmoid colon cancer; and 18 rectal cancer. Of the 48 patients, 31 were diagnosed with metastatic cancer and 17 had relapsed cancer after surgery, with adjuvant chemotherapy or chemoradiotherapy. In total, 413 cycles were administered (median 6 per patient; range 2-24). Toxicity was evaluated in 48 patient and response in 46. Major toxic effects were grade 3/4 thrombocytopenia (13%) and neutropenia (10%). The overall response rate was 54% [95% confidence interval (CI) 40% to 68%]. The median time to progression and median survival time were 8.5 (95% CI 6.2-10.9) months and 27.2 (95% CI 20.3-34.0) months, respectively. CONCLUSIONS These data indicate that the OS regimen is effective and well tolerated in patients with advanced colorectal cancer.
Variability in the South Pacific Deep Western Boundary Current from current meter observations and a high‐resolution global model

Observations of the South Pacific Deep Western Boundary Current from the World Ocean Circulation Experiment Pacific current meter array 9 (WOCE PCM-9) current meter array are compared with the Los Alamos National Laboratory high-resolution global ocean model. A simple integration of PCM-9 velocity yields a mean northward transport of water deeper than 3000 m that is some 5 times greater than the model mean transport of 3.35 × 106 m3 s−1. The low modeled abyssal transport suggests a poor simulation of the mean thermohaline circulation. However, model and observed transport variability correlate significantly. Space-time spectral analysis shows planetary waves are responsible for most of the variability and are resolved well in the model. The details of interaction of the long waves at the western boundary are different in model and data. The model reflects these waves predominantly as planetary short waves, which decay over the region 600–800 km east of the Kermadec Ridge. PCM-9 has a higher proportion of energy as topographic waves along the Kermadec Ridge. These two classes of waves are associated with the two observed zonal scales in the boundary current. The model results can be separated into vertical modes. Baroclinic energy is found at all timescales, including those too short for free baroclinic waves. The baroclinic flow correlates with the barotropic so as to enhance surface, and reduce abyssal, kinetic energy. This is the signature of planetary wave scattering at the submerged western boundary ridge, and results in enhanced baroclinic wave energy in the Tasman Sea.
Oblivious routing in directed graphs with random demands

Oblivious routing algorithms for general undirected networks were introduced by Räcke, and this work has led to many subsequent improvements and applications. More precisely, Räcke showed that there is an oblivious routing algorithm with polylogarithmic competitive ratio (w.r.t. edge congestion) for any undirected graph. Comparatively little positive results are known about oblivious routing in general directed networks. Using a novel approach, we present the first oblivious routing algorithm which is O(log2 n) competitive with high probability in directed graphs given that the demands are chosen randomly from a known demand-distribution. On the other hand, we show that no oblivious routing algorithm can be o(logn/log log n) competitive even with constant probability in general directed graphs.Our routing algorithms are not oblivious in the traditional definition, but we add the concept of demand-dependence, i.e., the path chosen for an s-t pair may depend on the demand between s and t. This concept that still preserves that routing decisions are only based on local information proves very powerful in our randomized demand model.Finally, we show that our approach for designing competitive oblivious routing algorithms is quite general and has applications in other contexts like stochastic scheduling.
Cerebral haemodynamics during experimental intracranial hypertension

Intracranial hypertension is a common final pathway in many acute neurological conditions. However, the cerebral haemodynamic response to acute intracranial hypertension is poorly understood. We assessed cerebral haemodynamics (arterial blood pressure, intracranial pressure, laser Doppler flowmetry, basilar artery Doppler flow velocity, and vascular wall tension) in 27 basilar artery-dependent rabbits during experimental (artificial CSF infusion) intracranial hypertension. From baseline (∼9 mmHg; SE 1.5) to moderate intracranial pressure (∼41 mmHg; SE 2.2), mean flow velocity remained unchanged (47 to 45 cm/s; p = 0.38), arterial blood pressure increased (88.8 to 94.2 mmHg; p < 0.01), whereas laser Doppler flowmetry and wall tension decreased (laser Doppler flowmetry 100 to 39.1% p < 0.001; wall tension 19.3 to 9.8 mmHg, p < 0.001). From moderate to high intracranial pressure (∼75 mmHg; SE 3.7), both mean flow velocity and laser Doppler flowmetry decreased (45 to 31.3 cm/s p < 0.001, laser Doppler flowmetry 39.1 to 13.3%, p < 0.001), arterial blood pressure increased still further (94.2 to 114.5 mmHg; p < 0.001), while wall tension was unchanged (9.7 to 9.6 mmHg; p = 0.35). This animal model of acute intracranial hypertension demonstrated two intracranial pressure-dependent cerebroprotective mechanisms: with moderate increases in intracranial pressure, wall tension decreased, and arterial blood pressure increased, while with severe increases in intracranial pressure, an arterial blood pressure increase predominated. Clinical monitoring of such phenomena could help individualise the management of neurocritical patients.
High-density lipoprotein cholesterol as a predictor of clinical outcomes in patients achieving low-density lipoprotein cholesterol targets with statins after percutaneous coronary intervention

Background A low level of high-density lipoprotein cholesterol (HDL-C) is strongly associated with cardiovascular events. However, the significance of HDL-C after statin therapy on the outcome of patients who have undergone percutaneous coronary intervention (PCI) with drug eluting stents (DES) is unclear. Objectives To investigate the significance of HDL-C after statin therapy on cardiovascular events in patients with coronary artery disease after DES implantation. Methods Patients who underwent PCI with DES from January 2004 to December 2009 were prospectively enrolled. The follow-up lipid panel of 2693 patients (median lab follow-up duration 225 days) who had continued using statins after PCI and who attained low-density lipoprotein cholesterol (LDL-C) <100 mg/dl was analysed. Major adverse cardiac events (MACE), including all-cause death, non-fatal myocardial infarction, and target vessel revascularisation according to follow-up HDL-C level (40 mg/dl for men or 50 mg/dl for women) were compared with the use of propensity scores matching. Results Median follow-up duration was 832 days. 1585 (58.9%) patients had low follow-up HDL-C and 1108 had high follow-up HDL-C. The low follow-up HDL-C group had significantly higher rates of MACE. Low follow-up HDL-C was a significant independent predictor of MACE (adjusted HR 1.404, 95% CI 1.111 to 1.774, p=0.004). In further analysis with propensity scores matching, overall findings were consistent. Conclusions Raising HDL-C levels may be a subsequent goal after achieving target LDL-C levels in patients with DES implantation.
Improving Inhibitory Control Abilities (ImpulsE)—A Promising Approach to Treat Impulsive Eating?

Although there is preliminary evidence that inhibitory control training improves impulsive eating, less is known about the effects on eating behaviour and weight loss in clinical samples. Sixty-nine treatment-seeking adults with obesity (binge-eating disorder 33.3%; other specific feeding and eating disorders 40.6%) were randomly blockwise allocated to ImpulsE, an intervention to improve inhibitory control and emotion regulation abilities or a guideline-appropriate cognitive behavioural therapy (CBT)-based treatment as usual. Self-reported and performance-based impulsivity, eating disorder pathology and BMI were compared at baseline (T1), post-treatment (T2) and 1- or 3-month follow-up. ImpulsE led to better food-specific inhibition performance (p = .004), but groups did not differ regarding improvements in global Eating Disorder Examination Questionnaire (EDE-Q) score at T2. At 3-month follow-up, binge eaters benefited most from ImpulsE (p = .028) and completers of ImpulsE demonstrated a significantly greater weight reduction (p = .030). The current findings propose ImpulsE as a promising approach to treat obesity, illustrating acceptability and additional benefits for course of weight. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.
Heart Failure and Atrial Fibrillation: From Basic Science to Clinical Practice

Heart failure (HF) and atrial fibrillation (AF) are two growing epidemics associated with significant morbidity and mortality. They often coexist due to common risk factors and shared pathophysiological mechanisms. Patients presenting with both HF and AF have a worse prognosis and present a particular therapeutic challenge to clinicians. This review aims to appraise the common pathophysiological background, as well as the prognostic and therapeutic implications of coexistent HF and AF.
Improved dosimetry in prostate brachytherapy using high resolution contrast enhanced magnetic resonance imaging: a feasibility study

Purpose To assess detailed dosimetry data for prostate and clinical relevant intra- and peri-prostatic structures including neurovascular bundles (NVB), urethra, and penile bulb (PB) from postbrachytherapy computed tomography (CT) versus high resolution contrast enhanced magnetic resonance imaging (HR-CEMRI). Material and methods Eleven postbrachytherapy prostate cancer patients underwent HR-CEMRI and CT imaging. Computed tomography and HR-CEMRI images were randomized and 2 independent expert readers created contours of prostate, intra- and peri-prostatic structures on each CT and HR-CEMRI scan for all 11 patients. Dosimetry data including V100, D90, and D100 was calculated from these contours. Results Mean V100 values from CT and HR-CEMRI contours were as follows: prostate (98.5% and 96.2%, p = 0.003), urethra (81.0% and 88.7%, p = 0.027), anterior rectal wall (ARW) (8.9% and 2.8%, p < 0.001), left NVB (77.9% and 51.5%, p = 0.002), right NVB (69.2% and 43.1%, p = 0.001), and PB (0.09% and 11.4%, p = 0.005). Mean D90 (Gy) derived from CT and HR-CEMRI contours were: prostate (167.6 and 150.3, p = 0.012), urethra (81.6 and 109.4, p = 0.041), ARW (2.5 and 0.11, p = 0.003), left NVB (98.2 and 58.6, p = 0.001), right NVB (87.5 and 55.5, p = 0.001), and PB (11.2 and 12.4, p = 0.554). Conclusions Findings of this study suggest that HR-CEMRI facilitates accurate and meaningful dosimetric assessment of prostate and clinically relevant structures, which is not possible with CT. Significant differences were seen between CT and HR-CEMRI, with volume overestimation of CT derived contours compared to HR-CEMRI.
Gridless wire ordering, sizing and spacing with critical area minimization

Designs for yield (DFY) problems have received increasing attention. Of particular concern in DFY problems is how to formulate and reduce a critical area for random defects. Arranging interconnections is recognized as an effective means of improving the sensitivity towards random defects. Previous works have demonstrated that random defects significantly influence interconnections and the effectiveness of layer assignment and track routing to enhance routing quality and performance. This work proposes a random defect aware layer assignment and gridless track routing (RAAT) to eliminate the effect of random defects. Gridless track routing comprises wire ordering, wire sizing and spacing in this work. Exposure ratio metric is proposed to assign each iroute to a specific layer efficiently. RAAT utilizes min-cut partitioning, a conventionally adopted method for placement and floorplanning, to place interconnections. Slicing tree-based structure improves the efficiency of wire ordering in lowering overlapped length between adjacent partitions. Finally, a second-order cone programming refined by considering an extra random-defect effect determines the position and width of each iroute. Experimental results demonstrate the necessity of the integration of layer assignment and track routing. Results further demonstrate the effectiveness of the gridless track routing methods proposed by RAAT. In addition to finishing each case more rapidly with higher completion rate than previous works do, RAAT reduces up to 20% of the number of failures in the Monte Carlo simulation as compared to previous works.
Transcription Activation by the Orphan Nuclear Receptor, Chicken Ovalbumin Upstream Promoter-Transcription Factor I (COUP-TFI)

Chicken ovalbumin upstream promoter-transcription factors (COUP-TFs), orphan members of the nuclear receptor superfamily, play a key role in the regulation of organogenesis, neurogenesis, and cellular differentiation during embryogenic development. COUP-TFs are also involved in the regulation of several genes that encode metabolic enzymes. Although COUP-TFs function as potent transcription repressors, there are at least three different molecular mechanisms of activation of gene expression by COUP-TFs. First, as we have previously shown, COUP-TF is required as an accessory factor for the complete induction of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids. This action is mediated by the binding of COUP-TF to the glucocorticoid accessory factor 1 (gAF1) and 3 (gAF3) elements in the phosphoenolpyruvate carboxykinase gene glucocorticoid response unit. In addition, COUP-TF1 binds to DNA elements in certain genes and transactivates directly. Finally, COUP-TF1 serves as a coactivator through DNA-bound hepatic nuclear factor 4. Here we show that the same region of COUP-TFI, located between amino acids 184 and 423, is involved in these three mechanisms of transactivation by COUP-TFI. Furthermore, we show that GRIP1 and SRC-1 potentiate the activity of COUP-TFI and that COUP-TFI associates with these coactivators in vivo using the same region required for transcription activation. Finally, overexpression of GRIP1 or SRC-1 does not convert COUP-TFI from a transcriptional repressor into a transcriptional activator in HeLa cells.