Miracle-dz/UniFAR-FTUs huggingface dataset:
Differential interaction of splicing snRNPs with coiled bodies and interchromatin granules during mitosis and assembly of daughter cell nuclei

In the interphase nucleus of mammalian cells the U1, U2, U4/U6, and U5 small nuclear ribonucleoproteins (snRNPs), which are subunits of spliceosomes, associate with specific subnuclear domains including interchromatin granules and coiled bodies. Here, we analyze the association of splicing snRNPs with these structures during mitosis and reassembly of daughter nuclei. At the onset of mitosis snRNPs are predominantly diffuse in the cytoplasm, although a subset remain associated with remnants of coiled bodies and clusters of mitotic interchromatin granules, respectively. The number and size of mitotic coiled bodies remain approximately unchanged from metaphase to early telophase while snRNP-containing clusters of mitotic interchromatin granules increase in size and number as cells progress from anaphase to telophase. During telophase snRNPs are transported into daughter nuclei while the clusters of mitotic interchromatin granules remain in the cytoplasm. The timing of nuclear import of splicing snRNPs closely correlates with the onset of transcriptional activity in daughter nuclei. When transcription restarts in telophase cells snRNPs have a diffuse nucleoplasmic distribution. As cells progress to G1 snRNP- containing clusters of interchromatin granules reappear in the nucleus. Coiled bodies appear later in G1, although the coiled body antigen, p80 coilin, enters early into telophase nuclei. After inhibition of transcription we still observe nuclear import of snRNPs and the subsequent appearance of snRNP-containing clusters of interchromatin granules, but not coiled body formation. These data demonstrate that snRNP associations with coiled bodies and interchromatin granules are differentially regulated during the cell division cycle and suggest that these structures play distinct roles connected with snRNP structure, transport, and/or function.
A 3.5GHz wideband ADPLL with fractional spur suppression through TDC dithering and feedforward compensation

The digital-intensive approach to frequency synthesis embodied by the ADPLL [1] has seen a flurry of recent activity [2–4] due to benefits in both performance (programmability, noise immunity) and integration (area reduction, easy porting) in nanoscale CMOS versus the traditional analog approach. However, the quantization of voltage and time—intrinsic to sampled-data systems—leads to problems with spurious tones and in-band phase noise the former of which has hitherto excluded the ADPLL from stringent wideband wireless applications. Low in-band phase noise requires a high-resolution TDC, whereas the dominant source of in-band spurious tones in an ADPLL is the TDC's nonlinearity, which is not directly coupled with TDC resolution. Although effective techniques to mitigate TDC nonlinearities have been proposed in [2,3], with worst-spur performance around −45dBc they are still far from analog state-of-the-art [6].
A visualization tool to detect refactoring opportunities in SOA applications

Service-oriented computing (SOC) has been widely used by software industry for building distributed software applications that can be run in heterogeneous environments. It has also been required that these applications should be both high-quality and adaptable to market changes. However, a major problem in this type of applications is its growth; as the size and complexity of applications increase, the probability of duplicity of code increases. This problem could have a negative impact on quality attributes, such as performance, maintenance and evolution, among others. This paper presents a web tool called VizSOC to assist software developers in detecting refactoring opportunities in service-oriented applications. The tool receives WSDL (Web Service Description Language) documents, detects anti-patterns and suggests how to resolve them, and delivers a list of refactoring suggestions to start working on the refactoring process. To visualize the results in an orderly and comprehensible way, we use the Hierarchical Edge Bundles (HEB) visualization technique. The experimentation of the tool has been supported using two real-life case-studies, where we measured the amount of anti-patterns detected and the performance of clustering algorithms by using internal validity criteria. The results indicate that VizSOC is an effective aid to detect refactoring opportunities, and also allows developers to reduce effort along the detection process.
A novel CSI-fed induction motor drive

Current source inverter (CSI) fed drives are employed in high power applications. The conventional CSI drives suffer from drawbacks such as harmonic resonance, unstable operation at low speed ranges, and torque pulsation. This paper presents a novel CSI drive which overcomes all these drawbacks and results in sinusoidal motor voltage and current even with CSI switching at fundamental frequency. The proposed CSI drive uses a three-level inverter as an active filter across motor terminals replacing the bulky ac capacitors used in the conventional drive. A sensorless vector controlled CSI drive based on proposed configuration is developed. The simulation and experimental results are presented. Experimental results show that the proposed drive has stable operation even at low speeds. Comparative results show that the proposed CSI drive has improved torque ripple compared to the conventional configuration.
An Overview of Developmental Research in Music.

Any attempt to outline an "overview of developmental research in music" first requires a retrospective look so that present understandings and practices can be viewed through the lens of past accomplishments and learnings. The last three decades have seen an increased interest in the systematic study of musical development, paralleling the systematic study of child development that has contributed to our understanding of human development and personality. Current emphases on human development stress its extreme boundaries, infancy and early childhood and the aging and aged. There are many reasons for the interest in early development. Developmental psychologists tell us that during the first five years of life the child learns more about his world than he will at any other time. Foundations for learning, for responding, and for personality development are formed. During these formative years (birth age 5) bases for maturity in the physical, social, emotional, intellectual, and musical aspects of life are being laid.
Dark Energy in Sparse Atomic Estimations

Sparse overcomplete methods, such as matching pursuit, attempt to find an efficient estimation of a signal using terms (atoms) selected from an overcomplete dictionary. In some cases, atoms can be selected that have energy in regions of the signal that have no energy. Other atoms are then used to destructively interfere with these terms in order to preserve the original waveform. Because some terms may even ldquodisappearrdquo in the reconstruction, we refer to the destructive and constructive interference between the atoms of a sparse atomic estimation as ldquodark energy.rdquo In this paper, we formally define dark energy for matching pursuit, explore its properties, and present empirical results for decompositions of audio signals. This paper demonstrates that dark energy is a useful measure of the interference between the terms of a sparse atomic estimation and might provide information for the decomposition process.
The relationship between childhood trauma and schizotypy and the pathways underlying this association

There is a growing body of literature demonstrating an association between childhood trauma and schizotypy (e.g. Afifi et al. 2011;Myin-Germeys et al. 2011). However, more research is required to build on methodological limitations of previous studies, explore the possible differential effects of specific trauma types and expand the focus from a single contributor (e.g. psychological, biological) by considering the additive/interactive contributors to schizotypal symptomatology. The aim of the thesis was to explore the relationship between a range of childhood traumatic experiences and schizotypy whilst also incorporating several social, psychological and genetic factors underlying these relationships. Participants were recruited as a part of a cross-sectional case-control study conducted in the London Boroughs of Lambeth and Southwark. The thesis covers a subsample of controls (N=212), healthy volunteers, aged 18-64 and residents in the same geographical area. Data were gathered using an in-depth standardised interview regarding childhood abuse (Childhood Experience of Care and Abuse - CECA) and The Structured Interview for Schizotypy – Revised (SIS-R) measuring a range of schizotypal symptoms and signs. The study found a linear association of total trauma and schizotypy (adj. β=.88, p=0.004), with the strongest associations observed for psychological (adj. OR=4.85, p=0.039) and physical abuse (adj. OR=3.56, p=0.003). These particular types of trauma had an especially robust effect on positive schizotypal traits (psychological: adj. OR=3.79, p=0.013; physical abuse: adj. OR=2.32, p=0.042), which are attenuated forms of positive symptoms of schizophrenia (e.g. hallucinations, delusions). Negative beliefs about self/others and depression were the main mediators of these associations. A strong relationship was found for genetic risk of psychosis and increased schizotypy (adj. β=3.41, p=0.015). Other moderators of the childhood trauma - schizotypy association were intrusive life events (adj. β=4.20, p=0.045). This study provides further insights into the association between childhood trauma and schizotypy and gives clues to pathways underlying this association.
Social Support, Self-image, and Future Outlook Among Poverty-stricken Unemployed Men in Namibia: A Phenomenological Study

The study aimed to explore how poverty-stricken job seekers in Namibia felt about their unemployment situation and how they perceived themselves, their social support, and their future. Ten men (aged 18 to 40 years) participated in the study. In-depth interviews were conducted and analysed through Interpretative Phenomenological Analysis. The findings revealed that the lack of a job and the constant shortage of food caused feelings of helplessness, nagging thoughts, and difficulties to sleep. All participants received very little social support from family and friends, which they attributed to their joblessness; they perceived their position within their social network as low and degrading. The participants' self-image was negatively inclined and dominated by their unemployment status. Their future outlook concentrated on finding a job but was overshadowed by worries and doubts.
Innate immune recognition of respiratory syncytial virus infection

Respiratory syncytial virus (RSV) is the leading cause of respiratory infection in infants and young children. Severe clinical manifestation of RSV infection is a bronchiolitis, which is common in infants under six months of age. Recently, RSV has been recognized as an important cause of respiratory infection in older populations with cardiovascular morbidity or immunocompromised patients. However, neither a vaccine nor an effective antiviral therapy is currently available. Moreover, the interaction between the host immune system and the RSV pathogen during an infection is not well understood. The innate immune system recognizes RSV through multiple mechanisms. The first innate immune RSV detectors are the pattern recognition receptors (PRRs), including toll-like receptors (TLRs), retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), and nucleotide-biding oligomerization domain (NOD)-like receptors (NLRs). The following is a review of studies associated with various PRRs that are responsible for RSV virion recognition and subsequent induction of the antiviral immune response during RSV infection. [BMB Reports 2014; 47(4): 184-191]
Data-aware interaction in distributed and collaborative workflows: Modeling, semantics, correctness

IT support for distributed and collaborative workflows as well as related interactions between business partners are becoming increasingly important. For modeling such partner interactions as flow of message exchanges, different top-down approaches, covered under the term interaction modeling, are provided. Like for workflow models, correctness constitutes a fundamental challenge for interaction models; e.g., to ensure the boundedness and absence of deadlocks and lifelocks. Due to their distributed execution, in addition, interaction models should be message-deterministic and realizable, i.e., the same conversation (i.e. sequence of messages) should always lead to the same result, and it should be ensured that partners always have enough information about the messages they must or may send in a given context. So far, most existing approaches have addressed correctness of interaction models without explicitly considering the data exchanged through messages and used for routing decisions. However, data support is crucial for collaborative workflows and interaction models respectively. This paper enriches interaction models with the data perspective. In particular, it defines the behavior of data-aware interaction models based on Data-Aware Interaction Nets, which use elements of both Interaction Petri Nets and Workflow Nets with Data. Finally, formal correctness criteria for Data-Aware Interaction Nets are derived, guaranteeing the boundedness and absence of deadlocks and lifelocks, and ensuring message-determinism as well as realizability.
High Performance Implementation of ARIA Encryption Algorithm on Graphics Processing Units

It becomes increasingly common to use GPU (Graphics Processing Units) as accelerators to speed up compute intensive sections of applications. Since block ciphers are supposed to be used for high speed encryption, it is important to implement them as fast as possible. Block cipher ARIA is a new type of encryption standard with four different S-boxes. This paper proposes three methods of high performance implementations of ARIA encryption algorithm on GPU. In order to reduce the data dependency, the round function of ARIA are merged into lookup tables and XOR operations. Encrypting process is performed in parallel and all the data in different GPU memory spaces are arranged properly. Experimental results demonstrate that these techniques accelerate the speed of ARIA encryption significantly. The quantitative performance comparison demonstrates acceleration up to 18 - 45 times speedup while the size of plaintext varies from 4M to 256M.
La pauvreté multidimensionnelle au Sénégal entre 2002 et 2006: une analyse par l'approche par la théorie des ensembles flous

Les resultats de l'estimation de la pauvrete monetaire sur la periode 2002 et 2006 au Senegal montrent une baisse significative de la pauvrete de 10% (voir chapitre 3). Cependant, selon l'Enquete sur la perception de la pauvrete au Senegal (EPPS) realisee en 2006, et portant sur le meme echantillon que celui de l'enquete suivi de la pauvrete au Senegal (ESPS - 2006), pres de deux tiers des menages estiment que la pauvrete a augmente dans leur communaute durant cette meme periode. Elle revele un ecart entre l'incidence de la pauvrete calculee selon un seuil de pauvrete monetaire et la perception que les populations ont eux-memes de l'evolution de leur condition de vie. Les menages estiment etre prives d'un certains nombre de besoins necessaires a une vie descente. Ceci etant l'approche monetaire de la pauvrete s'avere insuffisante. Pour cerner les multiples aspects de la pauvrete au Senegal, une analyse multidimensionnelle est alors necessaire pour etablir une mesure exhaustive de ce phenomene a partir d'une estimation des degres de privation de certains besoins essentiels des menages qui constitue l'objet de ce travil. L'approche par la theorie des ensembles flous est une parfaite voie pour une telle analyse.
Complex Thinking, Complex Practice: The Case for a Narrative Approach to Organizational Complexity

Complexity is not only a feature of the systems we study, it is also a matter of the way in which we organize our thinking about those systems. This second-order complexity invites consideration of the modes of thinking we use to theorize about complexity, and in this article we develop the idea of second-order complexity using Jerome Bruner’s contrast between logico-scientific and narrative modes of thinking. Using Bruner’s framework, we examine and critique dominant forms of thinking about organizational complexity that are rooted in the logico-scientific mode, and suggest alternatives based in the narrative mode. Our evidence for the value of doing this comes from the logic of complexity theory itself, which we claim indicates and supports the use of the narrative mode. The potential contribution of the narrative approach to developing second-order thinking about organizational complexity is demonstrated by taking a narrative approach to the matter of recursiveness. By extension, similar insights are indicated for other features that logico-scientific thinkers commonly attribute to complex systems, including, nonlinearity, indeterminacy, unpredictability and emergence.
Mechanisms and Functional Implications of Intestinal Barrier Defects

Intestinal epithelial barrier defects, or increased paracellular permeability, were first reported in patients with Crohn’s disease (CD) over 25 years ago. Although increased permeability may herald relapse to active disease, suggesting that impaired barrier function may contribute to progression, limited understanding of the mechanisms that create barrier defects in CD has made it impossible to determine whether increased permeability is a cause or effect of disease. It is now clear that inflammatory cytokines trigger intestinal barrier defects acutely, by cytoskeletal contraction, or chronically, via modulation of tight junction protein expression. Both mechanisms cause barrier dysfunction, but their effects on paracellular size and charge selectivity differ. The clinical ramifications of this distinction are not yet clear. Recent data using in vivo models demonstrate that cytoskeletally mediated barrier dysfunction is sufficient to activate innate and adaptive components of mucosal immunity. Consistent with the presence of increased permeability in some healthy first-degree relatives of CD patients, these barrier defects are insufficient to cause disease in the absence of other stimuli. However, cytoskeletally mediated barrier defects are sufficient to accelerate onset and increase severity of experimental inflammatory bowel disease. Thus, inflammatory cytokines can cause barrier defects and, conversely, barrier defects can activate the mucosal immune system. This raises the possibility that restoration of barrier function may be therapeutic in CD. Consistent with this hypothesis, emerging data indicate that inhibition of cytoskeletally mediated barrier dysfunction may be able to prevent disease progression. Barrier restoration may, therefore, represent a non-immunosuppressive approach to achieving or maintaining disease remission.
Direct Torque Control for Dual Three-Phase PMSM Based on Three-Phase Decomposition SVPWM

A direct torque control strategy for dual three-phase permanent magnet synchronous motors is presented in this paper. The motor has two sets of three-phase stator windings spatially phase shifted by 30 electrical degrees. In order to reduce the harmonic current in stator windings which has no contribution to torque production, torque and flux are controlled based on regulators and three-phase decomposition SVPWM technique. The proposed strategy has the advantages of constant switching frequency, low torque ripple and low distortion of stator current. The validity of the strategy is confirmed by simulation results.
Zum Einfluss von Ausländern auf die Wirtschaftsleistung von Standorten : ist Zuwanderung ein Weg aus der ostdeutschen Lethargie?

The paper investigates the potential impact of foreigners on economic development. Historic examples, various contemporary empirical observations and theory support the working thesis that regions which face a high quota of foreign residents may benefit from human capital spillovers between different ethnic groups. It is argued that immigration brings about both a more effective division of labour and mutual learning and leads thereby to higher per-capita-income. We apply these findings to the current economic sickliness of East-Germany and conclude that in this region a more committed immigration policy may prove to be an particularly appropriate remedy.
Macrophysiology for a changing world

The Millennium Ecosystem Assessment (MA) has identified climate change, habitat destruction, invasive species, overexploitation and pollution as the major drivers of biodiversity loss and sources of concern for human well-being. Understanding how these drivers operate and interact and how they might be mitigated are among the most pressing questions facing humanity. Here, we show how macrophysiology—the investigation of variation in physiological traits over large geographical, temporal and phylogenetic scales—can contribute significantly to answering these questions. We do so by demonstrating, for each of the MA drivers, how a macrophysiological approach can or has helped elucidate the impacts of these drivers and their interactions. Moreover, we illustrate that a large-scale physiological perspective can provide insights into previously unrecognized threats to diversity, such as the erosion of physiological variation and stress tolerance, which are a consequence of the removal of large species and individuals from the biosphere. In so doing we demonstrate that environmental physiologists have much to offer the scientific quest to resolve major environmental problems.
Influence des réseaux d'administrateurs sur la stratégie de la firme : application au cadre des partenariats stratégiques

L'objet de cette recherche est l'etude de l'impact de l'activite relationnelle des administrateurs sur le management strategique des entreprises. L'encastrement relationnel et cognitif des administrateurs leur permet d'apporter des ressources pertinentes pour la reflexion, la prise de decision et la mise en œuvre des choix strategiques. Pour apprehender cet encastrement et ses consequences en matiere de choix strategiques, nous avons mobilise le concept du capital social. Ce concept explique comment l'information, l'influence et les connaissances circulent entre les membres d'un reseau. Nos hypotheses portent sur le role du capital social des administrateurs d'une firme dans le declenchement des partenariats qu'elle mene. Elles ont ete testees a partir de l'etude du cas d'une entreprise francaise en biotechnologie et d'une etude econometrique fondee sur un questionnaire. Ces etudes montrent que le capital social des administrateurs facilite l'acces a certains contacts cles dans le declenchement des partenariats interentreprises. Ces relations sociales permettent, aussi, d'instaurer un climat de confiance qui facilite la negociation de ces accords.
Disclosing the LDPC code decoder design space

The design of future communication systems with high throughput demands will become a critical task, especially when sophisticated channel coding schemes have to be applied. LDPC codes are one of the most promising candidates because of their outstanding communications performance. One major problem for a decoder hardware realization is the huge design space composed of many interrelated parameters which enforces drastic design trade-offs. Another important issue is the need for flexibility of such systems. In this paper we illuminate this design space with special emphasis on the strong interrelations of theses parameters. Three design studies are presented to highlight the effects on a generic architecture if some parameters are constraint by a given standard, given technology, and given area constraints