Miracle-dz/UniFAR-FTUs huggingface dataset:
Prenatal and early postnatal NOAEL-dose clothianidin exposure leads to a reduction of germ cells in juvenile male mice

Neonicotinoids are pesticides used worldwide. They bind to insect nicotinic acetylcholine receptors (nAChRs) with high affinity. We previously reported that clothianidin (CTD), one of the latest neonicotinoids, reduced antioxidant expression and induced germ cell death in the adult testis of vertebrates. Here, we investigated the male reproductive toxicity of prenatal and early postnatal exposure to CTD, because it is likely that developmental exposure more severely affects the testis compared to adults due to the absence of the blood-testis barrier. Pregnant C57BL/6 mice were given water gel blended with CTD (0, 10 or 50 mg/kg/day; no-observed-adverse-effect-level [NOAEL for mice]: 47.2 mg/kg/day) between gestational day 1 and 14 days post-partum. We then examined the testes of male offspring at postnatal day 14. The testis weights and the numbers of germ cells per seminiferous tubule were decreased in the CTD-50 group, and abnormal tubules containing no germ cells appeared. Nevertheless, the apoptotic cell number and proliferative activity were not significantly different between the control and CTD-exposed groups. There were no significant differences in the androgen-related parameters, such as the Leydig cell volume per testis, the Sertoli cell number and the tubule diameter. The present study is the first demonstration that in utero and lactational exposures to CTD at around the NOAEL for mice reduce the germ cell number, but our findings suggest that these exposures do not affect steroidogenesis in Leydig cells during prenatal or early postnatal life.
CREATIVE PORTFOLIO STRATEGY AS A MODEL OF MANAGEMENT IN MEDIA COMPANY: AN EXAMPLE OF PUBLIC BROADCASTING

This paper deals with issues of functioning public media companies in the context of new technological possibilities of communication media and a keen commercial competition. A creative and dynamic portfol io has been proposed as a possible model of business s trategy. For a media organization that means the transition from traditional to modern business conc ept, which involves researching the characteristics , processes, challenges and impact of the portfolio o f media products. Special attention is given to the balance of the portfolio and orientation on the quality of the content of media products.
Application of Slope PWM Strategies to Reduce Acoustic Noise Radiated by Inverter-Fed Induction Motors

In this paper, two strategies based on the slope pulsewidth modulation (PWM) technique are applied to acoustic noise reduction in inverter-fed induction motors. This generated technique uses a trapezoidal modulator wave with a triangular or a sinusoidal carrier signal. The main advantage of the proposed method is that only two control parameters are necessary to achieve a voltage spectrum configuration that helps reduce radial electromagnetic forces. One of them modifies the amplitude of the modulated output of the inverter, and the other controls the frequency spectrum distribution. Small changes to these parameters can yield a wide range of electrical spectra that allow for selective acoustic harmonic reduction. Thus, it is possible to avoid the overlap of radial forces produced by the MMF time harmonic frequencies of the inverter and the radial forces produced by the MMF space harmonic frequencies due to the discretized distribution of stator winding in slots of the motor, maintaining the number of pulses per period chosen. Also, it can help to avoid activating the resonances due to the mechanical natural frequencies. Results are checked experimentally and compared to those of other PWM techniques.
Are impairment indicators and losses associated in Thailand

Purpose - The purpose of this research is to first examine whether the amount of impairment losses recognized by Thai listed firms is associated with the economic indicators suggested in the relevant accounting standard. Second, the study investigates whether efficiency versus opportunism dominates accounting for impairment by Thai listed firms. Design/methodology/approach - The multiple regression model is used to test whether impairment indicators and reporting incentives associate with impairment losses for a sample of 1,418 non-financial listed Thai companies during 1999-2004. Findings - Impairment losses are associated with all three levels (macro, industry, and firm-specific performance measures) of impairment indicators described in Thai Accounting Standard (TAS) No. 36 (which is in accordance with the IAS No. 36). The results also reveal that management opportunistically recognizes impairment losses to smooth earnings when earnings increase. Inconsistent with Francis Originality/value - This is the first study that provides empirical evidence for the indicators of assets' impairment prescribed in TAS/IAS No. 36. The results support the pre-condition indicators for measurement of impairment losses under TAS/IAS No. 36 in the emerging Thai capital market. Further, efficiency is documented to dominate opportunism as the principal of Thai firms' accounting policy with respect to asset impairment.
Correlation between Mutations in liaFSR of Enterococcus faecium and MIC of Daptomycin: Revisiting Daptomycin Breakpoints

ABSTRACT Mutations in liaFSR, a three-component regulatory system controlling cell-envelope stress response, were recently linked with the emergence of daptomycin (DAP) resistance in enterococci. Our previous work showed that a liaF mutation increased the DAP MIC of a vancomycin-resistant Enterococcus faecalis strain from 1 to 3 μg/ml (the DAP breakpoint is 4 μg/ml), suggesting that mutations in the liaFSR system could be a pivotal initial event in the development of DAP resistance. With the hypothesis that clinical enterococcal isolates with DAP MICs between 3 and 4 μg/ml might harbor mutations in liaFSR, we studied 38 Enterococcus faecium bloodstream isolates, of which 8 had DAP MICs between 3 and 4 μg/ml by Etest in Mueller-Hinton agar. Interestingly, 6 of these 8 isolates had predicted amino acid changes in the LiaFSR system. Moreover, we previously showed that among 6 DAP-resistant E. faecium isolates (MICs of >4 μg/ml), 5 had mutations in liaFSR. In contrast, none of 16 E. faecium isolates with a DAP MIC of ≤2 μg/ml harbored mutations in this system (P < 0.0001). All but one isolate with liaFSR changes exhibited DAP MICs of ≥16 μg/ml by Etest using brain heart infusion agar (BHIA), a medium that better supports enterococcal growth. Our findings provide a strong association between DAP MICs within the upper susceptibility range and mutations in the liaFSR system. Concomitant susceptibility testing on BHIA may be useful for identifying these E. faecium first-step mutants. Our results also suggest that the current DAP breakpoint for E. faecium may need to be reevaluated.
FeedFinder: A Location-Mapping Mobile Application for Breastfeeding Women

Breastfeeding is positively encouraged across many countries as a public health endeavour. The World Health Organisation recommends breastfeeding exclusively for the first six months of an infant's life. However, women can struggle to breastfeed, and to persist with breastfeeding, for a number of reasons from technique to social acceptance. This paper reports on four phases of a design and research project, from sensitising user-engagement and user-centred design, to the development and in-the-wild deployment of a mobile phone application called FeedFinder. FeedFinder has been developed with breastfeeding women to support them in finding, reviewing and sharing public breastfeeding places with other breastfeeding women. We discuss how mobile technologies can be designed to support public health endeavours, and suggest that public health technologies are better aimed at communities and societies rather than individual.
Top Executive Remuneration: A View from Europe

We argue that the dominance of principal-agent theory as an approach to investigating executive pay has led to an overly narrow focus which may be unhelpful when considering cross-country differences and probably also hinders within-country analysis. The paper discusses the interlinked nature of three available theoretical lenses, namely principal-agent, executive power, and stewardship/stakeholder theories. It argues that institutional theory can provide a useful overarching framework within which appropriate variants of these approaches can be deployed to better comprehend developments in executive pay. We illustrate our approach with a discussion of executive pay in the UK and in Germany. Copyright Blackwell Publishing Ltd 2005.
Efficacy of a clinical medication review on the number of potentially inappropriate prescriptions prescribed for community-dwelling elderly people.

BACKGROUND The administration of many drugs concurrently to elderly patients is a well-known problem in geriatrics and involves numerous risks. One way to reduce polypharmacy is to provide information to physicians in order to modify their prescribing practices. The main objective of this study was to evaluate the impact of an intervention program that targeted physicians with the aim of reducing the number of potentially inappropriate prescriptions (PIPs) given to elderly patients. METHODS A randomized controlled trial was carried out among community-dwelling elderly people in Sherbrooke, Que. The participants were 266 patients over 75 years of age (experimental group: n = 136, control group: n = 130). A team comprising 2 physicians, a pharmacist and a nurse reviewed the list of drugs and the diagnoses of a subgroup of the experimental group in a case conference. Suggestions were formulated and mailed to the patients' physicians together with relevant scientific documentation justifying the recommendations. The main outcome measure was the number of PIPs. RESULTS The mean number of PIPs per patient declined by 0.24 in the experimental group (n = 127) and by 0.15 in the control group (n = 116). The decline in PIPs was even larger in the experimental group that had case conferences (n = 80), in which the mean number of PIPs per patient declined by 0.31. However, this difference between the experimental group and the control group was not statistically significant in the intent-to-treat analysis. The number of drugs prescribed was not modified by the intervention, nor were the results of the global assessment of the patients' drug profiles. INTERPRETATION This study suggests that the intervention program had no effect on the prescribing of PIPs.
Online Social Shopping: The Functions and Symbols of Design Artifacts

We report the results from a study investigating online shoppers' perceptions and evaluations of online social shopping design artifacts. To do so, we use the framework developed by Markus and Silver (2008) for studying information technology artifacts and their effects. Hence, we examine the functional affordances, i.e., the potential uses, and the symbolic expressions, i.e., the underlying message guiding use, of a set of four artifacts that shopper-generated content :1) lists of (favorite) products from shoppers, 2) lists of online shopping friends, 3) product reviews, and 4) shoppers' profiles. The results from a survey of online shopper are preliminary but promising. They show that recreational and non-recreational shoppers perceive different potential uses and underlying messages in the artifacts, and that the nature of these perceptions (utilitarian vs. hedonic) are related to shoppers' assessment of the artifacts' utilitarian and hedonic value.
Estrogen attenuates gp120‐ and tat1–72‐induced oxidative stress and prevents loss of dopamine transporter function

Postmenopausal women who are infected with HIV are at risk for experiencing dementia and Parkinson's‐like symptoms associated with low levels of estrogen. Neurotoxic damage leading to these symptoms may involve HIV‐associated proteins gp120 and/or tat1–72 (tat). Our hypothesis is that 17β‐Estradiol (E2) is an effective agent for protection against gp120/tat‐induced damage associated with increased oxidative stress, with particular focus on peroxynitrite‐induced oxidative stress. We used SK‐N‐SH cells and striatal synaptosomes from Sprague‐Dawley rats as model systems to assess neuroprotection by E2. Cells coincubated with SIN‐1(3‐morpholinosydnonimine) or tat and gp120, together or separately, significantly increased oxidative stress on the SK‐N‐SH cells, as indicated by the increase in the levels of dichlorofluorescein (DCFH) fluorescence. These data suggest that a component of tat and gp120 neurotoxicity may be due to increased oxidative stress. Coincubation with E2 attenuated tat‐ and gp120‐induced increase in fluorescence. Coincubation with progesterone had no effect on tat‐induced fluorescence, whereas coincubation with the E2 antagonist ICI 182,780 and E2 completely prevented the effects observed with E2 alone. Both gp120 and tat decreased [3H] dopamine uptake into striatal synaptosomes by decreasing the Vmax of the dopamine transporter (DAT). Pretreatment of synaptosomes with E2 (100 nM) partially reversed this reduction. In conclusion, E2 appears to be effective for preventing the oxidative stress and loss of DAT function associated with gp120/tat neurotoxicity. Synapse 59:51–60, 2006. © 2005 Wiley‐Liss, Inc.
Testing Genotypic and Phenotypic Resistance in Human Immunodeficiency Virus Type 1 Isolates of Clade B and Other Clades from Children Failing Antiretroviral Therapy

ABSTRACT The emergence of resistance to antiretroviral drugs is a major obstacle to the successful treatment of human immunodeficiency virus type 1 (HIV-1)-infected patients. In this work, we correlate clinical and virological trends such as viral load (VL) and CD4 counts to genotypic and phenotypic antiretroviral (ARV) resistance profiles of HIV-1 isolates from the B and non-B subtypes found in vertically infected children failing ARV therapy. Plasma samples were collected from 52 vertically HIV-1-infected children failing different ARV therapies. Samples underwent HIV-1 pol sequencing and phenotyping and were clustered into subtypes by phylogenetic analysis. Clinical data from each patient were analyzed together with the resistance (genotypic and phenotypic) data obtained. Thirty-five samples were from subtype B, 10 samples were non-B (subtypes A, C, and F), and 7 were mosaic samples. There was no significant difference concerning treatment data between B and non-B clades. Prevalence of known drug resistance mutations revealed slightly significant differences among B and non-B subtypes: L10I, 21 and 64%, K20R, 13 and 43%, M36I, 34 and 100%, L63P, 76 and 36%, A71V/T, 24 and 0%, and V77I, 32 and 0%, respectively, in the protease (0.0001 ≤ P ≤ 0.0886), and D67N, 38 and 8%, K70R, 33 and 0%, R211K, 49 and 85%, and K219Q/E, 31 and 0%, respectively, in the reverse transcriptase (0.0256 ≤ P ≤ 0.0704). Significant differences were found only in secondary resistance mutations and did not reflect significant phenotypic variation between clade B and non-B.
Kernel selection in linear system identification part II: A classical perspective

In this companion paper, the choice of kernels for estimating the impulse response of linear stable systems is considered from a classical, “frequentist”, point of view. The kernel determines the regularization matrix in a regularized least squares estimate of an FIR model. The quality is assessed from a mean square error (MSE) perspective, and measures and algorithms for optimizing the MSE are discussed. The ideas are tested on the same data bank as used in Part I of the companion papers. The resulting findings and conclusions in the two papers are very similar despite the different perspectives.
Forecast accuracy of individual analysts in nine industries

The purpose of this paper is to investigate whether financial analysts with superior earnings forecasting ability can be distinguished on the basis of ex post forecast accuracy. I explore the question by estimating and comparing average accuracy across individuals, and by considering whether the observed distribution of analyst forecast accuracies differs from the distribution expected if their relative performances each year were purely random. Overall, I do not find systematic differences in forecast accuracy across individuals. Financial press coverage suggests there are superior financial analysts. For example, Institutional Investor's annual "All American Research Team" includes analysts rated by money managers as superior on a variety of criteria, including earnings forecasting, ability to pick stocks, and the quality of written reports. Clearly, financial analyst services other than forecast accuracy are valued by their clients. I focus on only one activity, earnings forecasting, for two reasons. First, forecast data are available, quantitative, and can be evaluated against observable earnings outcomes. Services such as insightful, well-written research reports are harder to evaluate quantitatively. Second, academic use of analyst forecasts as earnings expectations data in capital markets empir-
Understanding the Effect of Statins and Patient Adherence in Atherosclerosis via a Quantitative Systems Pharmacology Model Using a Novel, Hybrid, and Multi-Scale Approach

Background and Objective: Statins are one of the most prescribed drugs to treat atherosclerosis. They inhibit the hepatic HMG-CoA reductase, causing a reduction of circulating cholesterol and LDL levels. Statins have had undeniable success; however, the benefits of statin therapy crystallize only if patients adhere to the prescribed treatment, which is far away from reality since adherence decreases with time with around half of patients discontinue statin therapy within the first year. The objective of this work is to; firstly, demonstrate a formal in-silico methodology based on a hybrid, multiscale mathematical model used to study the effect of statin treatment on atherosclerosis under different patient scenarios, including cases where the influence of medication adherence is examined and secondly, to propose a flexible simulation framework that allows extensions or simplifications, allowing the possibility to design other complex simulation strategies, both interesting features for software development. Methods: Different mathematical modeling paradigms are used to present the relevant dynamic behavior observed in biological/physiological data and clinical trials. A combination of continuous and discrete event models are coupled to simulate the pharmacokinetics (PK) of statins, their pharmacodynamic (PD) effect on lipoproteins levels (e.g., LDL) and relevant inflammatory pathways whilst simultaneously studying the dynamic effect of flow-related variables on atherosclerosis progression. Results: Different scenarios were tested showing the impact of: (1) patient variability: a virtual population shows differences in plaque growth for different individuals could be as high as 100%; (2) statin effect on atherosclerosis: it is shown how a patient with a 1-year statin treatment will reduce his plaque growth by 2–3% in a 2-year period; (3) medical adherence: we show that a patient missing 10% of the total number of doses could increase the plaque growth by ~1% (after 2 years) compared to the same “regular” patient under a 1-year treatment with statins. Conclusions: The results in this paper describe the effect of pharmacological intervention combined with biological/physiological or behavioral factors in atherosclerosis progression and treatment in specific patients. It also provides an exemplar of basic research that can be practically developed into an application software.
Regulation of pancreatic endocrine function by cholecystokinin: studies with MK-329, a nonpeptide cholecystokinin receptor antagonist.

A cholecystokinin (CCK) receptor antagonist, MK-329, was used to explore the physiological role of CCK in regulating pancreatic endocrine function in humans. The ability of CCK to increase plasma pancreatic polypeptide (PP) concentrations and blockade of this effect with MK-329 were evaluated in a double blind, balanced, four-period cross-over study. Eight subjects received single oral doses of 0.5, 2, or 10 mg MK-329 or placebo, followed by an iv infusion of CCK-8 (34 ng/kg.h). In placebo-treated subjects, PP increased from basal levels of 70 +/- 15 (+/- SE) to peak values of 291 +/- 58 pg/mL after CCK infusion (P less than 0.05 compared to basal). This increase in plasma PP concentration was inhibited in a dose-dependent fashion by MK-329, with 10 mg antagonizing the stimulatory effect of CCK infusion by nearly 80%. Second, the effect of MK-329 on meal-stimulated pancreatic endocrine responses was evaluated by giving placebo or 10 mg MK-329 2 h before ingestion of a mixed meal. Eight subjects were treated in a randomized two-period cross-over fashion. With placebo treatment, peak postprandial plasma insulin, glucagon, and glucose concentrations were 101 +/- 8 microU/mL, 195 +/- 15 pg/mL, and 150 +/- 10 mg/dL, respectively (all P less than 0.05). The integrated PP response following the meal was 56.3 +/- 11.1 ng/mL.minute. With MK-329 treatment, the integrated PP concentration was reduced to 33.9 +/- 2.2 ng/mL.min (P less than 0.05 compared to placebo treatment). Mean postprandial insulin, glucagon, and glucose concentrations did not differ between placebo and MK-329 treatments. We conclude that CCK receptor blockade with 10 mg MK-329 does not alter plasma insulin, glucagon, or glucose responses to a mixed meal. However, the observation that physiological concentrations of CCK increase plasma levels of PP, and the finding that CCK receptor blockade selectively attenuates the postprandial increase in plasma PP concentrations support a physiological role for CCK in regulating PP secretion.
Export Adjustment to Currency Depreciation in the Presence of Parallel Markets for Foreign Exchange: The Experience of Selected Sub-Saharan African Countries in the 1980s

The primary focus of this study is an empirical investigation of the implications of parallel exchange markets for export adjustment to official currency depreciation. An econometric model incorporating the features of exchange control and credit constraint was estimated using pooled data from 13 Sub-Saharan African countries. A rise in the parallel currency premium was found to adversely affect official exports; and the estimates suggest that official depreciations which are launched in the presence of large exchange-rate misalignment and which succeed in reducing the latter are likely to exert greater favourable effects on export performance than otherwise equivalent depreciations.