Miracle-dz/UniFAR-FTUs huggingface dataset:
A 7 year follow-up of children and adolescents with obsessive-compulsive disorder: an analysis of predictive factors in a clinical prospective study

Obsessive compulsive disorder (OCD) is a frequent psychiatric disorder. Despite its significant influence on personal development, little is known about its long-term course in children and adolescents. The aim was to follow children and adolescents with OCD for 7 years and to compare patients gaining remission with patients experiencing symptoms. Methods: The study was a prospective follow-up study in which the patients were interviewed 7 years after their initial contact with the healthcare system. The patients had been described at baseline. Results: Among the 95 participants, 53 participants described symptoms at follow-up and 44 participants described remission. More patients with persistent symptoms described an anxious personality trait. The schizoid/compulsive personality traits were represented at a higher rate in the group with persistent symptoms than in the group with remission symptoms. Important predictive factors included predisposition to OCD, the occurrence of comorbid disorders and older referral age. The occurrence of magic obsessions and repetitive compulsions increased the risk of OC symptoms at follow-up. The group “late responders” differed from the non-responder group by predisposition to depression. Conclusions: The present clinical study is one of the longest follow-up studies conducted in children and adolescents with OCD. In addition to confirming several previous findings, the study added new knowledge about the importance of phenotypic presentation, personality traits and quality of life. Furthermore, the late responder group has been described in relation to the remission group and to the group with persistent symptoms.
The Role of Oxytocin in Human Affect

Social behavior is crucial for day-to-day activities, and oxytocin has emerged as playing a central regulatory role. Oxytocin increases positive social emotions such as trust and altruism, leading to the hypothesis that oxytocin facilitates positive prosocial behaviors. However, other findings suggest that oxytocin may play a more general role that includes the facilitation of negative social emotions. These findings have led to the broader social-salience hypothesis. We propose a third possible alternative explanation for the impact of oxytocin on negative social emotions and review evidence to support our social-approach/withdrawal hypothesis. We also provide directions for future studies, highlighting the need for a direct comparison of alternative hypotheses relating to the impact of oxytocin on human social behavior.
European Union Citizenship: Writing the Future

EU citizenship has matured as an institution, owing to a number of important interventions by the European Court of Justice and legislative initiatives, such as the Citizenship Directive 2004/38/EC, which has recently entered into force. In this article, I critically examine minimalist and cosmopolitan conceptions of European citizenship and argue that once we dispense with the preoccupation of assigning primacy to a specific level of citizenship and establishing some kind of hierarchy among them, we can begin to address the questions and issues that really matter. Among these are the future governance of citizenship and the design of a more inclusive, multilayered and multicultural conception of citizenship. European citizenship entails a number of fruitful ideas for a more ambitious transition to a post-national tableau and can be the prototype for institutional experimentation on citizenship on a global scale.
Transmission networks of HIV-1 among men having sex with men in the Netherlands

Objective: To obtain insight in the HIV-1 transmission networks among men having sex with men (MSM) in the Netherlands. Design: A phylogenetic tree was constructed from polymerase sequences isolated from 2877 HIV-1 subtype B-infected patients monitored as part of the AIDS Therapy Evaluation in the Netherlands (ATHENA) nationwide observational cohort. Methods: For MSM with a known date of infection, the most similar sequences were selected as potential transmission pairs when they clustered with bootstrap value of at least 99%. Time from infection to onward transmission was estimated as the median time between dates of infection for each transmission pair. The source of infections with a resistant strain was traced using the entire phylogenetic tree. Results: Of sequences from 403 MSM with a known date of infection between 1987 and 2007, 175 (43%) formed 63 clusters. Median time to onward transmission was 1.4 years (interquartile range 0.6–2.7). Twenty-four (6%) MSM carried a virus with resistance-related mutations, 13 of these were in eight clusters together with sequences from 28 other patients in the entire phylogenetic tree. Six clusters contained sequences obtained from 29 men all presenting the same resistance-related mutations. Conclusion: From our selection of likely transmission pairs, we conclude that onward transmission of HIV-1 from infected MSM in the Netherlands happens both during and after primary infection. Transmission of resistant strains from the antiretroviral therapy-treated population is limited, but strains with resistance-related mutations have formed subepidemics.
The Politics of Place: Place-making versus Densification in Toronto's Tower Neighbourhoods

type="main"> Toronto's Tower Neighbourhood Renewal (TR) programme is a municipal government initiative tackling aging high-rise apartment building clusters in need of physical upgrades. One strategy for a more vibrant future for those clusters is densification or new infill housing. The main argument of the essay is that the unique urban structure of Toronto's inner suburbs challenges the implementation of TR's densification strategy. The proximity of many residents occupying privately owned single-family homes close to the tower neighbourhoods has implications for the governance of TR in Toronto. Having created place-frames firmly linked to their own identities as single-family homeowners, these residents reject an encroachment of the ‘urban' (through higher residential densities) and of the ‘Other' (through a potential increase in low-income, immigrant and visible minority tower renters). A 2011 design charrette in the Toronto neighbourhood of Weston serves as a case study, exemplifying the tensions between neighbourhood resident place-frames and the goals of the TR project. This essay is based on an analysis of public policy documents and public participation reports, as well as notes from direct observation during the Weston 2021 Design Charrette.
Becoming Occluded: The Transition to Motherhood of Women with Postnatal Depression

A grounded theory methodology was used to develop a psychological account of the transition to motherhood of nine women who had received diagnoses of postnatal depression (PND). A core construct, termed “Becoming Occluded,” was identified in the analysis. This captured a five-phase psychological process model. The process began with participants' anticipation of motherhood. In the second phase, participants were overwhelmed by responsibility for their infants' dependency. In the third phase, they became emotionally fragmented by attempting to meet their infants' needs. Difficult interactive experiences, such as those around feeding, exacerbated mothers' sense of inadequacy, leading them into a fourth phase of negative self-evaluation. The final phase represented re-emergence from distress, in which participants distanced themselves from their infants' dependency. Clinical implications of the study included the identification of early signs of PND and potential utility of psychological therapies for mothers considered vulnerable to depression.
Policy-Based Resource Management and Service Provisioning in GMPLS Networks

Emerging network applications tend to be built over heterogeneous network resources spanning multiple management domains. Many such applications have dynamic demands for dedicated, deterministic, high-bandwidth connections. The generalized multi-protocol label switching (GMPLS) networks under development can address these kinds of demands by using policy-based resource management and service provisioning technologies. In this paper, we present the architecture and implementation for policy-based resource management and service provisioning as part of the work on the NSF funded dynamic resource allocation via GMPLS optical networks (DRAGON) Project. This work captures several critical features of service-oriented GMPLS networks, including a) collaborative interdomain resource management; b) interdomain end-to-end path computation; c) advance scheduled provisioning; and d) authentication, authorization and accounting (AAA). These features rely on the capability of exchanging and coordinating resource and policy information among multiple participating domains. In pursuit of this capability, we propose a three-dimensional (3D) resource computation model (RCM). The three broad dimensions of this model are traffic engineering (TE) constraints, time schedule constraints, and AAA policy constraints. The 3D RCM facilitates policy based resource allocation based on many specific constraints within these three broad categories. Based on this model we describe our approach to GMPLS interdomain end-to-end path computation, advance scheduled provisioning, and AAA policy based provisioning, respectively. Our current DRAGON implementation status is also reported in this paper.
Demo: FlexRAN: A Software-Defined RAN Platform

Although SDN is considered as one of the key technologies behind the impending 5G evolution of mobile networks, the opportunity of reaping its benefits is largely still untapped on the Radio Access Network (RAN) side due to the lack of a software-defined RAN (SD-RAN) platform. In this work we demonstrate the capabilities of FlexRAN, an open-source SD-RAN platform developed to fill this void. FlexRAN separates the RAN control and data planes with a custom-tailored southbound API. Besides it features a hierarchical control plane architecture that enables programmability, flexible and dynamic control function placement (allowing different degrees of coordination within and among base stations) and real-time control. Virtualized control functions and control delegation are two key features in FlexRAN that makes these capabilities possible. This demo illustrates the capabilities and the performance of FlexRAN based on a prototype implementation, while its applicability is highlighted through a Mobile Edge Computing use case, where it acts as an enabler of a video bitrate adaptation application based on the radio conditions at the network edge.
Medical Treatment of Intracranial Atherosclerosis: An Update

For patients with symptomatic intracranial atherosclerosis (ICAS), antithrombotic agents are the mainstay of therapy. Anticoagulation (warfarin) is not widely used since it is not more effective than aspirin and carries a high risk of bleeding. New oral anticoagulants are showing promise, but their use has not been investigated in appropriate clinical trials. Since the recurrent stroke risk is high with aspirin monotherapy, dual antiplatelets are considered in the early stage of symptomatic ICAS. Based on the Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events (CHANCE) and Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) results, aspirin plus clopidogrel has been recommended. However, this combination was not superior to aspirin monotherapy in patients with ICAS in the CHANCE substudy. Progression of ICAS is common, and it is associated with recurrent strokes. In the Trial of Cilostazol in Symptomatic Intracranial Arterial Stenosis (TOSS) study, aspirin plus cilostazol was more effective than aspirin monotherapy in preventing progression. The TOSS II trial showed that the overall change in stenosis was better with aspirin plus cilostazol than with aspirin plus clopidogrel. Aside from antithrombotic therapy, risk factor management is critical for secondary prevention, and high blood pressure is clearly linked to recurrent stroke. However, blood pressure may have to be cautiously managed in the early stage of stroke. Considering that ICAS is the major cause of stroke worldwide, further investigations are needed to establish optimal management strategies for patients with ICAS.
1 Corinthians 7 as a Foundation for a Christian Sex Ethic

Our culture's sexual behavior has been described by Rollo May as "schizoid. " We congratulate ourselves on having overthrown our ancestors' so-called Victorian sexual attitudes, and we recognize the natural andjoyful phenomenon of sex. Our society abounds in opportunities for freedom in sexuality, and this liberty is supported by dogmas from our new priesthood, the social scientists. However, we are more and more unsure as to the real meaning of our sexuality. We are witnessing a new type of guilt, one arising from the inability of some to participate in "liberated" sexual behavior.1 The Christian tradition, as is well known, is caught up in our culture's attempt to solve this irony. Such activity continued theological ethics' historic interest in the parameters of human sexuality. The current trend of the Christian tradition, in its attempt to produce a viable sex ethic, is to see the Christian faith as a liberating force. To varying degrees, the consensus seems to call for sexual freedom and joy grounded in Christian freedom and a'y r". However, the Christian tradition holds some ironies which are sui generis in regard to the questions of human sexuality. For example, the great exponent of Christian freedom, Paul of Tarsus, is clearly an embarrassment to the current trend in Christian sex ethics.2 First Corinthians 7 indicates to many that Paul is "sexist," and, ' yivot-ro, Paul appears to call for sexual asceticism (7: ib). Robin Scroggs, in two recent articles,3 has made an attempt to free
THE CENTRAL PATH OF THE PUPILLOCONSTRICTOR REFLEX IN RESPONSE TO LIGHT

A part of the work being done on the optic system in the laboratory of Northwestern University Medical School has been concerned with determining the central path of the pupilloconstrictor reflex in response to light. Information concerning this path should be of general interest as well as of clinical value in providing the anatomic basis for an understanding of the Argyll Robertson pupil and other disturbances of pupillary innervation. Certain features of the course taken by the light reflex are already known. The work of Karplus and Kreidl 1 on the cat and the monkey established that the constrictor pathway runs centrad from the optic tract in the brachium of the superior colliculus. In spite of a large amount of contrary evidence, the view has long been held that the impulses pass from the brachium into the tectum of the superior colliculus, and thence by way of the tectobulbar tract
A Question Answering System Developed as a Project in a Natural Language Processing Course

This paper describes the Question Answering System constructed during a one semester graduate-level course on Natural Language Processing (NLP). We hypothesized that by using a combination of syntactic and semantic features and machine learning techniques, we could improve the accuracy of question answering on the test set of the Remedia corpus over the reported levels. The approach, although novel, was not entirely successful in the time frame of the course.
A fine education but no “bluestocking”: Harriett Amies, pioneer female accounting professional

Harriett Amies (1907–2006) was the first female Bachelor of Commerce graduate of the University of Melbourne and the first female to qualify for membership of an accounting professional body in Victoria largely on the basis of tertiary qualifications. Her career encompassed teaching and accounting, as well as army service during World War II. In a last altruistic gesture, she donated her body to the Department of Anatomy at the University of Melbourne, coming full circle back to her alma mater. Her life and career spanned almost a century, one in which women went from almost no presence in the public arenas of universities and the professions, to almost equal representation in numbers of students and members. A narrative and interpretive approach to the life and career of Harriett Amies contributes to the literature on gender and accounting history, including the social construction of the accounting professional and women’s economic self-determination.
Data management in the APPA P2P system

Peer-to-peer (P2P) computing offers new opportunities for building highly distributed data systems. Unlike client-server computing, P2P is a very dynamic environment where peers can join and leave the network at any time and offers important advantages such as operation without central coordination, peers autonomy, and scale up to large number of peers. However, providing high-level data management services (schema, queries, replication, availability, etc.) in a P2P system implies revisiting distributed database technology in major ways. In this paper, we present APPA (Atlas Peer-to-Peer Architecture) and its high-level data management services. APPA has a network-independent architecture that can be implemented over various structured and super-peer P2P networks. It uses novel solutions for persistent data management with updates, data replication with semantic-based reconciliation and query processing. APPA's services are implemented using the JXTA framework.
DinTucker: Scaling Up Gaussian Process Models on Large Multidimensional Arrays

Tensor decomposition methods are effective tools for modelling multidimensional array data (i.e., tensors). Among them, nonparametric Bayesian models, such as Infinite Tucker Decomposition (InfTucker), are more powerful than multilinear factorization approaches, including Tucker and PARAFAC, and usually achieve better predictive performance. However, they are difficult to handle massive data due to a prohibitively high training cost. To address this limitation, we propose Distributed infinite Tucker (DinTucker), a new hierarchical Bayesian model that enables local learning of InfTucker on subarrays and global information integration from local results. We further develop a distributed stochastic gradient descent algorithm, coupled with variational inference for model estimation. In addition, the connection between DinTucker and InfTucker is revealed in terms of model evidence. Experiments demonstrate that DinTucker maintains the predictive accuracy of InfTucker and is scalable on massive data: On multidimensional arrays with billions of elements from two real-world applications, DinTucker achieves significantly higher prediction accuracy with less training time, compared with the state-of-the-art large-scale tensor decomposition method, GigaTensor.
Layer-Specific fMRI Reflects Different Neuronal Computations at Different Depths in Human V1

Recent work has established that cerebral blood flow is regulated at a spatial scale that can be resolved by high field fMRI to show cortical columns in humans. While cortical columns represent a cluster of neurons with similar response properties (spanning from the pial surface to the white matter), important information regarding neuronal interactions and computational processes is also contained within a single column, distributed across the six cortical lamina. A basic understanding of underlying neuronal circuitry or computations may be revealed through investigations of the distribution of neural responses at different cortical depths. In this study, we used T2-weighted imaging with 0.7 mm (isotropic) resolution to measure fMRI responses at different depths in the gray matter while human subjects observed images with either recognizable or scrambled (physically impossible) objects. Intact and scrambled images were partially occluded, resulting in clusters of activity distributed across primary visual cortex. A subset of the identified clusters of voxels showed a preference for scrambled objects over intact; in these clusters, the fMRI response in middle layers was stronger during the presentation of scrambled objects than during the presentation of intact objects. A second experiment, using stimuli targeted at either the magnocellular or the parvocellular visual pathway, shows that laminar profiles in response to parvocellular-targeted stimuli peak in more superficial layers. These findings provide new evidence for the differential sensitivity of high-field fMRI to modulations of the neural responses at different cortical depths.
Symbolism and the construction of political products: analysis of the political marketing strategies of peruvian President Alejandro Toledo

This paper introduces a discussion on how to construct and systematise symbols constructions that serve to define the guidelines for political discourses, using rhetorical methodology. It analyses the political marketing strategies of current Peruvian President Alejandro Toledo and, more specifically, his efforts to recover popularity after one-and-a-half years in office. The fundamental hypothesis is that Toledo has not been able to construct a solid character (apart from being in opposition to Alberto Fujimori), who would be the protagonist in the ‘story’ of solving the real problems of the people, which, according to the opinion polls, are lack of employment, lack of opportunities, and lack of money for daily expenses. The rhetorical approach, based on Kenneth Burke's Dramatism Theory, is useful for understanding the construction of the political spectacle, the scene where all the marketing strategies and tools are applied. Copyright © 2004 Henry Stewart Publications
An Integrated Model for Advancing the Scholarship of Engagement: Creating Academic Homes for the Engaged Scholar

A new integrated model is offered for the preparation of future faculty that addresses the transformation of institutions of higher education into supportive environments for the next generation of engaged scholars. Drawing on the knowledge bases of the scholarship of engagement, institutional change, preparing future faculty, the role of disciplinary associations, and promising practice for institutional engagement, the model provides a framework for approaches that would prepare individuals (primarily doctoral students and early career faculty) as learners of engagement while instigating and catalyzing institutions as learning organizations.
The Iron-Dependent Regulator Fur Controls Pheromone Signaling Systems and Luminescence in the Squid Symbiont Vibrio fischeri ES114

ABSTRACT Bacteria often use pheromones to coordinate group behaviors in specific environments. While high cell density is required for pheromones to achieve stimulatory levels, environmental cues can also influence pheromone accumulation and signaling. For the squid symbiont Vibrio fischeri ES114, bioluminescence requires pheromone-mediated regulation, and this signaling is induced in the host to a greater extent than in culture, even at an equivalent cell density. Our goal is to better understand this environment-specific control over pheromone signaling and bioluminescence. Previous work with V. fischeri MJ1 showed that iron limitation induces luminescence, and we recently found that ES114 encounters a low-iron environment in its host. Here we show that ES114 induces luminescence at lower cell density and achieves brighter luminescence in low-iron media. This iron-dependent effect on luminescence required ferric uptake regulator (Fur), which we propose influences two pheromone signaling master regulators, LitR and LuxR. Genetic and bioinformatic analyses suggested that under low-iron conditions, Fur-mediated repression of litR is relieved, enabling more LitR to perform its established role as an activator of luxR. Interestingly, Fur may similarly control the LitR homolog SmcR of Vibrio vulnificus. These results reveal an intriguing regulatory link between low-iron conditions, which are often encountered in host tissues, and pheromone-dependent master regulators.