Miracle-dz/UniFAR-FTUs huggingface dataset:
Multi-Objective Optimization Design for Electromagnetic Devices With Permanent Magnet Based on Approximation Model and Distributed Cooperative Particle Swarm Optimization Algorithm

Electromagnetic devices containing permanent magnet (PM) are common and typical electromagnetic devices that have advantages of low-power consumption, small size, high sensitivity, and its optimization problem has aroused widespread concern. Calculation accuracy of electromagnetic properties and efficiency of optimization processes are two important factors that affect the optimization effect of electromagnetic devices. A fast calculation method was proposed in this paper that aimed at electromagnetic devices with PM characteristics of strong non-linearity and low solving precision. The response surface method was used to derive the basis function, and the error between actual measured values and calculated values was modified by the Kriging method. On the basis of the calculation model, the distributed collaborative strategy was adopted to fulfill the parallel execution of the fast computation. Simultaneously, the updating strategy of particles was improved, and the robustness of the multi-objective particle swarm optimization algorithm in solving the optimization problem of electromagnetic devices with PM was enhanced. Effectiveness of the method proposed in this paper was verified by the case study of a specific type of electromagnetic relay with PM.
Biodistribution and Radiation Dosimetry of the Anti-HER2 Affibody Molecule 68Ga-ABY-025 in Breast Cancer Patients

68Ga-ABY-025 is a radiolabeled Affibody molecule for in vivo diagnosis of human epidermal growth factor receptor 2 (HER2)–positive breast cancer tumors with PET. The aim of the present work was to measure the biodistribution and estimate the radiation dosimetry of 68Ga-ABY-025 for 2 different peptide mass doses in a single group of patients using dynamic and serial whole-body PET/CT. Methods: Eight patients with metastatic breast cancer were included. Each patient underwent an abdominal 45-min dynamic and 3 whole-body PET/CT scans at 1, 2, and 4 h after injection of a low peptide dose (LD) and a high peptide dose (HD), with approximately the same amount of radioactivity, in separate investigations 1 wk apart. As input to the absorbed dose calculations, volumes of interest were drawn on all clearly identifiable source organs: liver, kidneys, spleen, descending aorta, and upper large intestine. Absorbed doses were calculated using OLINDA/EXM, version 1.1. Results: Of the major organs, the highest radionuclide uptake at 1, 2, and 4 h after injection was observed in the kidneys and liver. The highest absorbed organ doses were seen in the kidneys, followed by the liver for both LD and HD 68Ga-ABY-025. Absorbed doses to liver and kidneys were slightly but significantly higher for LD. Total effective dose was 0.030 ± 0.003 mSv/MBq for LD and 0.028 ± 0.002 mSv/MBq for HD. Conclusion: The effective dose for a typical 200-MBq administration of 68Ga-ABY-025 is 6.0 mSv for LD and 5.6 mSv for HD. Therefore, from a radiation dosimetry point of view, HD is preferred for PET/CT evaluation of HER2-expressing breast cancer tumors. These effective doses are somewhat higher than earlier published values for other 68Ga-labeled tracers, such as 0.021 ± 0.003 mSv/MBq for 68Ga-DOTATATE and 68Ga-DOTATOC, mainly because of higher uptake in liver and kidney.
Effects of virtual reality for stroke individuals based on the International Classification of Functioning and Health: a systematic review

Abstract Objective: This review determines the effects of virtual reality interventions for stroke subjects based on the International Classification of Functioning, Disability,and Health (ICF) framework. Virtual reality is a promising tool for therapy for stroke rehabilitation, but the effects of virtual reality interventions on post-stroke patients based on the specific ICF domains (Body Structures, Body Functions, Activity, and Participation) have not been investigated. Method: A systematic review was conducted, including trials with adults with a clinical diagnosis of a chronic, subacute, or acute stroke. Eligible trials had to include studies with an intervention protocol and follow-up, with a focus on upper limbs and/or lower limbs and/or balance. The Physiotherapy Evidence Database (PEDro) was used to assess the methodological quality of randomized controlled trials. Each trial was separated according to methodological quality into a high-quality trial (PEDro ≥ 6) and a low-quality trial (PEDro ≤ 6). Only high-quality trials were analyzed specifically based on the outcome of these trials. Results: In total, 54 trials involving 1811 participants were included. Of the papers included and considered high quality, 14 trials evaluated areas of the Body Structures component, 20 trials of the Body Functions domain, 17 trials of the Activity component, and 8 trials of the Participation domain. In relation to ICF Part 2, four trials evaluated areas of the Personal Factors component and one trial evaluated domains of the Environmental Factors component. Discussion: The effects of virtual reality on stroke rehabilitation based on the ICF framework are positive in Body Function and Body Structure. However, the results in the domains Activity and Participation are inconclusive. More high-quality clinical trials are needed to confirm the effectiveness of virtual reality in the domains of Activity and Participation.
The determinants of successful collaboration: A review of theoretical and empirical studies

Successful collaboration in health care teams can be attributed to numerous elements, including processes at work in interpersonal relationships within the team (the interactional determinants), conditions within the organization (the organizational determinants), and the organization's environment (the systemic determinants). Through a review of the literature, this article presents a tabulated compilation of each of these determinant types as identified by empirical research and identifies the main characteristics of these determinants according to the conceptual work. We then present a “showcase” of recent Canadian policy initiatives – The Canadian Health Transition Fund (HTF) – to illustrate how the various categories of determinants can be mobilized. The literature review reveals that very little of the empirical work has dealt with determinants of interprofessional collaboration in health, particularly its organizational and systemic determinants. Furthermore, our overview of experience at the Canadian HTF suggests that a systemic approach should be adopted in evaluative research on the determinants of effective collaborative practice.
Pronounced Hyperactivity, Cognitive Dysfunctions, and BDNF Dysregulation in Dopamine Transporter Knock-out Rats

Dopamine (DA) controls many vital physiological functions and is critically involved in several neuropsychiatric disorders such as schizophrenia and attention deficit hyperactivity disorder. The major function of the plasma membrane dopamine transporter (DAT) is the rapid uptake of released DA into presynaptic nerve terminals leading to control of both the extracellular levels of DA and the intracellular stores of DA. Here, we present a newly developed strain of rats in which the gene encoding DAT knockout Rats (DAT-KO) has been disrupted by using zinc finger nuclease technology. Male and female DAT-KO rats develop normally but weigh less than heterozygote and wild-type rats and demonstrate pronounced spontaneous locomotor hyperactivity. While striatal extracellular DA lifetime and concentrations are significantly increased, the total tissue content of DA is markedly decreased demonstrating the key role of DAT in the control of DA neurotransmission. Hyperactivity of DAT-KO rats can be counteracted by amphetamine, methylphenidate, the partial Trace Amine-Associated Receptor 1 (TAAR1) agonist RO5203648 ((S)-4-(3,4-Dichloro-phenyl)-4,5-dihydro-oxazol-2-ylamine) and haloperidol. DAT-KO rats also demonstrate a deficit in working memory and sensorimotor gating tests, less propensity to develop obsessive behaviors and show strong dysregulation in frontostriatal BDNF function. DAT-KO rats could provide a novel translational model for human diseases involving aberrant DA function and/or mutations affecting DAT or related regulatory mechanisms. SIGNIFICANCE STATEMENT Here, we present a newly developed strain of rats in which the gene encoding the dopamine transporter (DAT) has been disrupted (Dopamine Transporter Knockout rats [DAT-KO rats]). DAT-KO rats display functional hyperdopaminergia accompanied by pronounced spontaneous locomotor hyperactivity. Hyperactivity of DAT-KO rats can be counteracted by amphetamine, methylphenidate, and a few other compounds exerting inhibitory action on dopamine-dependent hyperactivity. DAT-KO rats also demonstrate cognitive deficits in working memory and sensorimotor gating tests, less propensity to develop compulsive behaviors, and strong dysregulation in frontostriatal BDNF function. These observations highlight the key role of DAT in the control of brain dopaminergic transmission. DAT-KO rats could provide a novel translational model for human diseases involving aberrant dopamine functions.
Regenerative Medicine and the Biliary Tree

Abstract Despite decades of basic research, biliary diseases remain prevalent, highly morbid, and notoriously difficult to treat. We have, however, dramatically increased our understanding of biliary developmental biology, cholangiocyte pathophysiology, and the endogenous mechanisms of biliary regeneration and repair. All of this complex and rapidly evolving knowledge coincides with an explosion of new technological advances in the area of regenerative medicine. New breakthroughs such as induced pluripotent stem cells and organoid culture are increasingly being applied to the biliary system; it is only a matter of time until new regenerative therapeutics for the cholangiopathies are unveiled. In this review, the authors integrate what is known about biliary development, regeneration, and repair, and link these conceptual advances to the technological breakthroughs that are collectively driving the emergence of a new global field in biliary regenerative medicine.
Relation classification from unstructured medical text using feature based machine learning approach

There is a lot of useful information available in medical documents. Information as medical named entities, relationship between medical entities, medical summary and etc. Most of the time such information in medical documents is unstructured and available in nonstandard natural language so it is difficult to automatically collect and present this information in a structured way. Structured information can be present as clinical entity in the text, relationship between clinical entities, summary of the text, etc. To get the specific information from the text, many rule based and machine learning techniques are widely used. In this article we propose a feature based machine learning model for relation classification task. We will also discuss a relative comparison with existing relation classification model.
“It just made me feel so desolate”: Patients’ narratives of weight gain following laparoscopic insertion of a gastric band

AIMS AND OBJECTIVES To describe the experiences of patients who have failed to maintain weight loss following the insertion of a laparoscopic adjustable gastric band (LAGB) for the treatment of morbid obesity. BACKGROUND Obesity is a global health problem resulting in physical, psychological and economic problems and presenting challenges for health services. Surgical intervention is an increasingly common approach to treatment; however, some patients do not sustain their weight loss following bariatric surgery and little is known about people's longer-term experiences following LAGB insertion. DESIGN A narrative-based qualitative interview study. METHODS A purposive sample of ten participants who had undergone LAGB insertion for morbid obesity was recruited. Semistructured interviews were conducted in 2014. Thematic analysis identified codes and emerging themes common to the participants' experiences. FINDINGS Three major themes emerged: living with the side effects, regret and lack of support. These reflect the difficulties participants experienced and provide new insights on why weight loss is not sustained after 2 years following surgery. CONCLUSION Participants reported that the surgery had a detrimental effect on their lives and some regretted having the band inserted. These findings identify areas of care that need to be addressed if patients undergoing LAGB are to experience its potential benefits and indicate that further research is needed into the long-term effects of gastric band insertion. Patients need to be better informed about the consequences of bariatric surgery if it is to have a lasting impact on their weight reduction. RELEVANCE TO CLINICAL PRACTICE Patients require comprehensive information and support before and after LAGB insertion to develop strategies which will help them lose weight and sustain it over the longer term. Clinicians need to be sensitive to patients' needs when weight loss plateaus or weight is regained and intensify support during these periods.
Antidiabetic and protective effects of the aqueous extract of Arbutus unedo L. in streptozotocin-nicotinamide-induced diabetic mice

Abstract Background Diabetes mellitus (DM) is currently a major health problem and the most common chronic disease worldwide. Traditional medicinal plants remedies remain a potential adjunct therapy to maintain better glycemic control while also imparting few side-effects. Arbutus unedo L. has been traditionally used to manage several diseases including diabetes. This study was undertaken to contribute the validation of the traditional use of Arbutus unedoL. (Ericaceae) in the treatment of diabetes. Methods In-vitro antidiabetic effect of the A. unedo roots aqueous extract was conducted using α-glucosidase and α-amylase assays. While in-vivo antidiabetic activity was conducted using streptozotocin-nicotinamide (STZ-NA) induced diabetic mice. Diabetic animals were orally administered the aqueous extract in 500 mg/kg of body weight to assess the antidiabetic effect. The blood glucose level and body weight of the experimental animals were monitored for 4 weeks. In addition, the histopathological examination of the treated mice pancreas was also conducted to observe the changes of β-cells during the treatment process. Results The extract produced a significant decrease in blood glucose level in diabetic mice. This decrease was equivalent to that which observed in mice treated with a standard after 2–4 weeks. In addition, the plant extract exhibited a potent inhibitory effect on α-amylase and α-glucosidase activity with IC50 values of 730.15±0.25 μg/mL and 94.81±5.99 μg/mL, respectively. Moreover, the histopathologic examination of the pancreas showed a restoration of normal pancreatic islet cell architecture which observed in the diabetic mice treated with plant extract. Conclusions The aqueous A. unedo roots extract has a significant in vitro and in vivo antidiabetic effects and improves metabolic alterations. The revealed results justify its traditional medicinal use.
Suppression of Multiple Scattering in a Depolarized Light-Scattering Experiment Using the One-Beam Setup

We have performed depolarized dynamic light-scattering measurements of suspensions of colloidal spherical particles made of tetrafluoroethylene copolymerized with perfluoromethylvinylether (MFA). Measurements on highly concentrated turbid suspensions of 17 wt% MFA in water show that the one-beam cross-correlation technique successfully suppresses the multiple scattering contributions. This is the first time that a cross-correlation technique has been used in a depolarized scattering experiment.
High-energy backscattered electron imaging of voids in aluminum metallizations

Backscattered electron imaging of microcircuits in scanning transmission electron microscopes at 120 kV is shown to produce improved images of voids in passivated Al metallization lines relative to those obtained with scanning electron microscopes at {le} 40 kV. At 120 kV, resolutions of about 0.1 {mu}m are achieved for voids imaged beneath 1.0 {mu}m glass overlayers. This technique allows improved characterization of microstructures for basic investigations of void formation and more accurate counting of voids in microcircuits without removing glass overlayers. Smaller voids should also be detectable with the higher voltage. 7 refs., 6 figs.
Micromechanical constitutive models forcementitious composite materials

A micromechanical constitutive model for concrete is proposed in which microcrack initiation, in the interfacial transition zone between aggregate particles and cement matrix, is governed by an exterior-point Eshelby solution. The model assumes a two-phase elastic composite, derived from an Eshelby solution and the Mori-Tanaka homogenization method, to which circular microcracks are added. A multi-component rough crack contact model is employed to simulate normal and shear behaviour of rough microcrack surfaces. It is shown, based on numerical predictions of uniaxial, biaxial and triaxial behaviour that the model captures key characteristics of concrete behaviour. An important aspect of the approach taken in this work is the adherence to a mechanistic modelling philosophy. In this regard the model is distinctly more rigorously mechanistic than its more phenomenological predecessors. Following this philosophy, a new more comprehensive crack-plane model is described which could be applied to crack-planes in the above model. In this model the crack surface is idealised as a series of conical teeth and corresponding recesses of variable height and slope. Based on this geometrical characterization, an effective contact function is derived to relate the contact stresses on the sides of the teeth to the net crack-plane stresses. Plastic embedment and frictional sliding are simulated using a local plasticity model in which the plastic surfaces are expressed in terms of the contact surface function. Numerical simulations of several direct shear tests indicate a good performance of the model. The incorporation of this crack-plane model in the overall constitutive model is the next step in the development of the latter. Computational aspects such as contact related numerical instability and accuracy of spherical integration rules employed in the constitutive model are also discussed. A smoothed contact state function is proposed to remove spurious contact chatter behaviour at a constitutive level. Finally, an initial assessment of the performance of the micromechanical model when implemented in a finite element program is presented. This evaluation clearly demonstrates the capability of the proposed model to simulate the behaviour of plain and reinforced concrete structural elements as well as demonstrating the potential of the micromechanical approach to achieve a robust and comprehensive model for concrete.
Delay-optimal buffered decode-and-forward for two-hop networks with random link connectivity

Delay-optimal control of multi-hop networks remains a challenging problem even in the simplest scenarios. In this paper, we consider delay-optimal control of a two-hop half-duplex network with i.i. d. on-off fading. Both the source node and the relay node are equipped with infinite buffers and have exogenous bit arrivals. We focus on delay-optimal link selection to minimize the average bit delay subject to a half-duplex constraint. To solve the problem, we introduce a new approach whereby an actual discrete time system (ADTS) is approximated using a virtual continuous time system (VCTS). Using dynamic programming, we recursively solve the delay minimization problem in the VCTS in terms of a simpler prototype problem, which can be addressed using continuous-time optimal control techniques. We show that the obtained solution in the VCTS is asymptotically optimal in the ADTS. Our solution has a closed-form expression and does not require knowledge of the arrival statistics. Finally, using renewal theory and the theory of random walks, we analyze the average delay resulting from the asymptotically optimal solution.
Effects of a water extract of Lepidium meyenii root in different models of persistent pain in rats

Abstract Lepidium meyenii (Walp.), commonly called maca, is an Andean crop belonging to the Brassicaceae family. Maca hypocotils are habitually consumed as customary food as well as traditional remedies for pathological conditions such as infertility. Moreover, the characterization of maca extracts revealed the presence of compounds that are able to modulate the nervous system. Aimed to evaluate the efficacy of L. meyenii in persistent pain, the present study analyzed the effects of a commercial root extract from maca in different animal models reproducing the most common causes of chronic painful pathologies. A qualitative characterization of this commercial extract by high performance liquid chromatography-mass spectrometry and tandem mass spectrometry analyses allowed us to confirm the presence of some macamides known as bioactive constituents of this root and the absence of the main aromatic glucosinolates. The acute oral administration of maca extract is able to reduce mechanical hypersensitivity and postural unbalance induced by the intra-articular injection of monoiodoacetate and the chronic-constriction injury of the sciatic nerve. Furthermore, L. meyenii extract reverts pain threshold alterations evoked by oxaliplatin and paclitaxel. A good safety profile in mice and rats was shown. In conclusion, the present maca extract could be considered as a therapeutic opportunity to relieve articular and neuropathic pain.
Comparison of Conventional Syringe, CanalBrush, EndoActivator, Photon-Induced Photoacoustic Streaming, and Manual Instrumentation in Removing Orange-Brown Precipitate: An In Vitro Study.

OBJECTIVE The aim of this in vitro study was to compare the various techniques for removing precipitate formed after irrigation with sodium hypochlorite (NaOCl) and chlorhexidine (CHX). BACKGROUND DATA It is still unclear whether different irrigant activation systems can effectively remove precipitate that is firmly attached to the root canal walls. METHODS Eighty-two extracted single-rooted human teeth were instrumented by using the ProTaper rotary system. The roots were irrigated with 5% NaOCl and then 2% CHX to form orange-brown precipitate on the root canal walls. The teeth were sectioned longitudinally, and the amount of precipitate on the canal walls was measured under a stereomicroscope at 15 × magnification before the root halves were reassembled. Then, conventional syringe irrigation (CSI), CanalBrush (CB), EndoActivator (EA) system, photon-induced photoacoustic streaming (PIPS), and manual instrumentation (MI) techniques were used to remove the precipitate, during which 5 mL of distilled water was used for 1 min. The amount of precipitate remaining on the canal walls was measured, and the percentage of precipitate removed was calculated. Data were analyzed by using the Kruskal-Wallis and Mann-Whitney U tests (p = 0.05). RESULTS All experimental groups contained residual precipitate. The precipitate was more effectively removed in the MI group than in the other groups (p < 0.05). The CB and EA groups showed better removal than the CSI and PIPS groups (p < 0.05), and there were no significant differences in removal between these latter two groups (p > 0.05). CONCLUSIONS None of the techniques used was able to completely remove the orange-brown precipitate from the root canal surfaces.