Miracle-dz/UniFAR-FTUs huggingface dataset:
A field-based recommender system for crop disease detection using machine learning

This study investigates crop disease monitoring with real-time information feedback to smallholder farmers. Proper crop disease diagnosis tools and information about agricultural practices are key to growth and development in the agricultural sector. The research was piloted in a rural community of smallholder farmers having 100 farmers participating in a system that performs diagnosis on cassava diseases and provides advisory recommendation services with real-time information. Here, we present a field-based recommendation system that provides real-time feedback on crop disease diagnosis. Our recommender system is based on question–answer pairs, and it is built using machine learning and natural language processing techniques. We study and experiment with various algorithms that are considered state-of-the-art in the field. The best performance is achieved with the sentence BERT model (RetBERT), which obtains a BLEU score of 50.8%, which we think is limited by the limited amount of available data. The application tool integrates both online and offline services since farmers come from remote areas where internet is limited. Success in this study will result in a large trial to validate its applicability for use in alleviating the food security problem in sub-Saharan Africa.
Abnormal left atrial compliance is associated with a history of life-threatening arrhythmia in corrected Tetralogy of Fallot

Objectives The objectives of this study were to examine left atrial (LA) function and compliance using two-dimensional (2D) strain analysis in adult patients with corrected Tetralogy of Fallot (c-ToF) and to investigate the relationships between LA function and patient characteristics, especially history of life-threatening arrhythmia (h-LTA). Methods Fifty-one c-ToF patients (34 males; age, 39 ± 15 years; h-LTA, n = 13) were included in this retrospective monocenter study. In addition to a 2D standard echocardiography examination, 2D strain analysis was performed to assess left ventricular (LV) and LA functions, including peak-positive LA strain (LAS—reservoir function) and LA compliance [defined as the ratio LAS/(E/Ea)]. Results Patients with h-LTA were older and exhibited a longer QRS duration. LV ejection fraction, LAS and LA compliance were significantly lower in the group of patients with h-LTA. Indexed LA and RA volumes, RV end-diastolic area was significantly higher and RV fractional area change significantly lower in the h-LTA group. LA compliance was the best echocardiographic predictor for h-LTA (AUC: 0.839; p < 0.001). Moderate inverted correlations were found between LA compliance and age and QRS duration. Among the echocardiographic parameters, LA compliance was moderately inversely correlated with RV end-diastolic area (r = −0.40, p = 0.01). Conclusion We documented abnormal LAS and LA compliance values in adult c-ToF patients. Further study is needed to determine how best to incorporate LA strain, particularly LA compliance, into multiparametric predictive models for LTA in c-ToF patients.
Procedural sedation in pediatric dentistry: a narrative review

Procedural sedation and analgesia are now considered standard care for managing pain and anxiety in pediatric dental patients undergoing diagnostic and therapeutic procedures outside of the operating room. Anxiolysis, which combines both pharmacologic and non-pharmacologic approaches, plays a significant role in procedural sedation. Non-pharmacologic interventions such as Behavior Management Technology can help reduce preprocedural agitation, ease the transition to sedation, reduce the required amount of medication for effective sedation, and decrease the occurrence of adverse events. As the introduction of novel sedative regimen and methods in pediatric dentistry, the potential role of mainstay sedatives administered by new routes, for new indications, and with new delivery techniques, should be considered. The purpose of this paper is to examine and discuss the current state of sedation techniques in pediatric dentistry.
Integration of visual context in early and late bilingual language processing: evidence from eye-tracking

Previous research on the processing of language embedded in a rich visual context has revealed the strong effect that a recently viewed action event has on language comprehension. It has been shown that listeners are more likely to view the target object of a recently performed event than look at the target object of a plausible future event during sentence utterance, regardless of the tense cue. In the current visual-world eye-tracking experiments, we tested the strength of the recently observed visual context with a group of English monolingual and two groups of English–French early and late bilingual speakers. By comparing these different groups, we examined whether bilingual speakers, as a consequence of greater cognitive flexibility when integrating visual context and language information, show early anticipatory eye-movements toward the target object. We further asked whether early and late bilinguals show differences in their processing. The findings of the three eye-tracking experiments revealed an overall preference for the recently seen event. However, as a result of the early provision of tense cue, this preference was quickly diminished in all three groups. Moreover, the bilingual groups showed an earlier decrease in reliance on the recently seen event compared to monolingual speakers and the early bilinguals showed anticipatory eye-movements toward the plausible future event target. Furthermore, a post-experimental memory test revealed that the bilingual groups recalled the future events marginally better than the recent events, whereas the reverse was found in the monolingual groups.
Specificity of striatal dopamine D1 system in humans: implications for clinical use of D1 receptor-agonists in Parkinson's disease

COPYRIGHT © 2023 Goto. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Specificity of striatal dopamine D1 system in humans: implications for clinical use of D1 receptor-agonists in Parkinson’s disease
A frequent SNP in TRIM5α strongly enhances the innate immune response against LINE-1 elements

The intracellular restriction factor TRIM5α inhibits endogenous LINE-1 retroelements. It induces innate immune signaling cascades upon sensing of cytoplasmic LINE-1 complexes, thereby underlining its importance for protecting the human genome from harmful retrotransposition events. Here, we show that a frequent SNP within the RING domain of TRIM5α, resulting in the variant H43Y, blocks LINE-1 retrotransposition with higher efficiency compared to TRIM5α WT. Upon sensing of LINE-1 complexes in the cytoplasm, TRIM5α H43Y activates both NF-κB and AP-1 signaling pathways more potently than TRIM5α WT, triggering a strong block of the LINE-1 promoter. Interestingly, the H43Y allele lost its antiviral function suggesting that its enhanced activity against endogenous LINE-1 elements is the driving force behind its maintenance within the population. Thus, our study suggests that the H43Y variant of the restriction factor and sensor TRIM5α persists within the human population since it preserves our genome from uncontrolled LINE-1 retrotransposition with higher efficiency.
Alterations in the intestinal microbiome and metabolic profile of patients with cirrhosis supplemented with lactulose, Clostridium butyricum, and Bifidobacterium longum infantis: a randomized placebo-controlled trial

Background Liver cirrhosis is commonly accompanied by intestinal dysbiosis and metabolic defects. Many clinical trials have shown microbiota-targeting strategies represent promising interventions for managing cirrhosis and its complications. However, the influences of the intestinal metagenomes and metabolic profiles of patients have not been fully elucidated. Methods We administered lactulose, Clostridium butyricum, and Bifidobacterium longum infantis as a synbiotic and used shotgun metagenomics and non-targeted metabolomics to characterize the results. Results Patients treated with the synbiotic for 12 weeks had lower dysbiosis index (DI) scores than placebo-treated patients and patients at baseline (NIP group). We identified 48 bacterial taxa enriched in the various groups, 66 differentially expressed genes, 18 differentially expressed virulence factor genes, 10 differentially expressed carbohydrate-active enzyme genes, and 173 metabolites present at differing concentrations in the Synbiotic versus Placebo group, and the Synbiotic versus NIP group. And Bifidobacteria species, especially B. longum, showed positive associations with many differentially expressed genes in synbiotic-treated patients. Metabolites pathway enrichment analysis showed that synbiotic significantly affected purine metabolism and aminoacyl-tRNA biosynthesis. And the purine metabolism and aminoacyl-tRNA biosynthesis were no longer significant differences in the Synbiotic group versus the healthy controls group. In conclusion, although littles influence on clinical parameters in the early intervention, the synbiotic showed a potential benefit to patients by ameliorating intestinal dysbiosis and metabolic defects; and the DI of intestinal microbiota is useful for the evaluation of the effect of clinical microbiota-targeting strategies on cirrhotic patients. Clinical Trial Registration https://www.clinicaltrials. gov, identifiers NCT05687409.
Noise and vestibular perception of passive self-motion

Noise defined as random disturbances is ubiquitous in both the external environment and the nervous system. Depending on the context, noise can degrade or improve information processing and performance. In all cases, it contributes to neural systems dynamics. We review some effects of various sources of noise on the neural processing of self-motion signals at different stages of the vestibular pathways and the resulting perceptual responses. Hair cells in the inner ear reduce the impact of noise by means of mechanical and neural filtering. Hair cells synapse on regular and irregular afferents. Variability of discharge (noise) is low in regular afferents and high in irregular units. The high variability of irregular units provides information about the envelope of naturalistic head motion stimuli. A subset of neurons in the vestibular nuclei and thalamus are optimally tuned to noisy motion stimuli that reproduce the statistics of naturalistic head movements. In the thalamus, variability of neural discharge increases with increasing motion amplitude but saturates at high amplitudes, accounting for behavioral violation of Weber’s law. In general, the precision of individual vestibular neurons in encoding head motion is worse than the perceptual precision measured behaviorally. However, the global precision predicted by neural population codes matches the high behavioral precision. The latter is estimated by means of psychometric functions for detection or discrimination of whole-body displacements. Vestibular motion thresholds (inverse of precision) reflect the contribution of intrinsic and extrinsic noise to perception. Vestibular motion thresholds tend to deteriorate progressively after the age of 40 years, possibly due to oxidative stress resulting from high discharge rates and metabolic loads of vestibular afferents. In the elderly, vestibular thresholds correlate with postural stability: the higher the threshold, the greater is the postural imbalance and risk of falling. Experimental application of optimal levels of either galvanic noise or whole-body oscillations can ameliorate vestibular function with a mechanism reminiscent of stochastic resonance. Assessment of vestibular thresholds is diagnostic in several types of vestibulopathies, and vestibular stimulation might be useful in vestibular rehabilitation.
Gradient adaptive sampling and multiple temporal scale 3D CNNs for tactile object recognition

Tactile object recognition (TOR) is very important for the accurate perception of robots. Most of the TOR methods usually adopt uniform sampling strategy to randomly select tactile frames from a sequence of frames, which will lead to a dilemma problem, i.e., acquiring the tactile frames with high sampling rate will get lots of redundant data, while the low sampling rate will miss important information. In addition, the existing methods usually adopt single time scale to construct TOR model, which will induce that the generalization capability is not enough for processing the tactile data generated under different grasping speeds. To address the first problem, a novel gradient adaptive sampling (GAS) strategy is proposed, which can adaptively determine the sampling interval according to the importance of tactile data, therefore, the key information can be acquired as much as possible when the number of tactile frames is limited. To handle the second problem, a multiple temporal scale 3D convolutional neural networks (MTS-3DCNNs) model is proposed, which downsamples the input tactile frames with multiple temporal scales (MTSs) and extracts the MTS deep features, and the fused features have better generalization capability for recognizing the object grasped with different speed. Furthermore, the existing lightweight network ResNet3D-18 is modified to obtain a MR3D-18 network which can match the tactile data with smaller size and prevent the overfitting problem. The ablation studies show the effectiveness of GAS strategy, MTS-3DCNNs, and MR3D-18 networks. The comprehensive comparisons with advanced methods demonstrate that our method is SOTA on two benchmarks.
Metabolic cost of osmoregulation by the gastro-intestinal tract in marine teleost fish

Introduction: Although dozens of studies have attempted to determine the metabolic cost of osmoregulation, mainly by comparing standard metabolic rates (SMR) in fish acclimated to different salinities, consensus is still lacking. Methods: In the present study, using the Gulf toadfish, Opsanus beta, we aimed to determine the metabolic cost of esophageal and intestinal osmoregulatory processes by estimating ATP consumption from known ion transport rates and pathways and comparing these estimates with measurements on isolated tissues. Further, we performed whole animal respirometry on fish acclimated to 9, 34 and 60 ppt. Results and Discussion: Our theoretical estimates of esophageal and intestinal osmoregulatory costs were in close agreement with direct measurements on isolated tissues and suggest that osmoregulation by these tissues amounts to ∼2.5% of SMR. This value agrees well with an earlier attempt to estimate osmoregulation cost from ion transport rates and combined with published measurements of gill osmoregulatory costs suggests that whole animal costs of osmoregulation in marine teleosts is ∼7.5% of SMR. As in many previous studies, our whole animal measurements were variable between fish and did not seem suited to determine osmoregulatory costs. While the esophagus showed constant metabolic rate regardless of acclimation salinity, the intestine of fish acclimated to higher salinities showed elevated metabolic rates. The esophagus and the intestine had 2.1 and 3.2-fold higher metabolic rates than corresponding whole animal mass specific rates, respectively. The intestinal tissue displays at least four different Cl− uptake pathways of which the Na+:Cl−:2 K+ (NKCC) pathway accounts for 95% of the Cl− uptake and is the most energy efficient. The remaining pathways are via apical anion exchange and seem to primarily serve luminal alkalinization and the formation of intestinal CaCO3 which is essential for water absorption.
Applied behavioral analysis for the skill performance of children with autism spectrum disorder

Introduction Autism spectrum disorder (ASD) has characteristics that have been observed to develop over time, such as the difficulty of affective, sensory, and emotional processing, which trigger some problems during childhood, limiting children's development. Applied behavior analysis (ABA) is among the therapeutic approaches for ASD, in which treatment can be tailored according to the patient's objectives. Objective Based on ABA, we aimed to analyze the therapeutic strategy for independence in different skill performance tasks of patients diagnosed with ASD. Method This is a retrospective observational case series study including 16 children diagnosed with ASD who received ABA-based treatment at a therapeutic clinic in Santo Andre city, São Paulo State, Brazil. Individual task performance of different skill domains was registered in the ABA+ affective intelligence® software throughout the 12 months (from January 2021 to January 2022) of routine treatment. Results The evolution of skills was observed between the T0 and T1 intervals, with improved skills over the observed period. Conclusion The strategy based on the ABA methodology improved children's skill performance over the observed period.
Breakdown of long-range spatial correlations of infraslow amplitude fluctuations of EEG oscillations in patients with current and past major depressive disorder

Introduction Identifying biomarkers for depression from brain activity is important for the diagnosis and treatment of depression disorders. We investigated spatial correlations of the amplitude fluctuations of electroencephalography (EEG) oscillations as a potential biomarker of depression. The amplitude fluctuations of EEG oscillations intrinsically reveal both temporal and spatial correlations, indicating rapid and functional organization of the brain networks. Amid these correlations, long-range temporal correlations are reportedly impaired in patients with depression, exhibiting amplitude fluctuations closer to a random process. Based on this occurrence, we hypothesized that the spatial correlations of amplitude fluctuations would also be altered by depression. Methods In the present study, we extracted the amplitude fluctuations of EEG oscillations by filtering them through infraslow frequency band (0.05–0.1 Hz). Results We found that the amplitude fluctuations of theta oscillations during eye-closed rest depicted lower levels of spatial correlation in patients with major depressive disorder (MDD) compared to control individuals. This breakdown of spatial correlations was most prominent in the left fronto - temporal network, specifically in patients with current MDD rather than in those with past MDD. We also found that the amplitude fluctuations of alpha oscillations during eye-open rest exhibited lower levels of spatial correlation in patients with past MDD compared to control individuals or patients with current MDD. Discussion Our results suggest that breakdown of long-range spatial correlations may offer a biomarker for the diagnosis of depression (current MDD), as well as the tracking of the recovery from depression (past MDD).
Socioeconomic inequality in the worsening of psychosocial wellbeing via disrupted social conditions during COVID-19 among adolescents in Hong Kong: self-resilience matters

Background Adolescents, especially the socioeconomically disadvantaged, are facing devastating psychosocial impact of the COVID-19 pandemic during their critical developmental period. This study aims to (i) examine the socioeconomic patterning of the worsening of psychosocial wellbeing, (ii) delineate the underlying mediating factors (i.e., overall worry about COVID-19, family's financial difficulty, learning problems, and loneliness), and (iii) explore the moderating effect of resilience in the inter-relationship among adolescents under COVID-19. Methods Based on maximum variation sampling of 12 secondary schools of diverse socioeconomic background in Hong Kong, 1018 students aged 14-16 years were recruited and completed the online survey between September and October 2021. Multi-group structural equation modeling (SEM) by resilience levels was employed to delineate the pathways between socioeconomic position and the worsening of psychosocial wellbeing. Results SEM analysis showed a significant total effect of socioeconomic ladder with the worsening of psychosocial wellbeing during the pandemic in the overall sample (β = −0.149 [95% CI = −0.217 – −0.081], p < 0.001), which operated indirectly through learning problems and loneliness (both p < 0.001 for their indirect effects). Consistent pattern with stronger effect size was observed in the lower resilience group; nonetheless, the associations were substantially mitigated in the higher resilience group. Conclusion In addition to facilitating self-directed learning and easing loneliness during the pandemic, evidence-based strategies to build up resilience among adolescents are critical to buffer against the adverse socioeconomic and psychosocial impacts of the pandemic or other potential catastrophic events in the future.
Literacy-related differences in morphological knowledge: A nonce-word study

Using a nonce-word inflection task, we examine the morphosyntactic productivity of adult native speakers of Spanish who are either beginning to learn to read and write (semi-literates) or have acquired literacy in late adulthood (late-literates), as well as age-matched controls (high-literates). High-literates consistently provided the appropriate form more often than late-literates, who in turn were better than semi-literate participants. Crucially, group interacted with person, number, and conjugation, such that the between-group differences were larger for the less frequent cells in the paradigm, indicating that literacy-related differences are not merely a consequence of the high-literacy group being more engaged or test-wise. This suggests that the availability of written representations may facilitate the acquisition of certain aspects of grammar. We also observed vast individual differences in productivity with inflectional endings. These results add to the growing body of research which challenges the assumption that all native speakers converge on the same grammar early in development.
Oxygen availability influences the incidence of testicular teratoma in Dnd1Ter/+ mice

Testicular teratomas and teratocarcinomas are the most common testicular germ cell tumors in early childhood and young men, and they are frequently found unilaterally in the left testis. In 129/SvJ mice carrying a heterozygous copy of the potent modifier of tumor incidence Ter, a point mutation in the dead-end homolog one gene (Dnd1 Ter/+ ), ∼70% of the unilateral teratomas arise in the left testis. We previously showed that in mice, left/right differences in vascular architecture are associated with reduced hemoglobin saturation and increased levels of the hypoxia inducible factor-1 alpha (HIF-1α) in the left compared to the right testis. To test the hypothesis that systemic reduction of oxygen availability in Dnd1 Ter/+ mice would lead to an increased incidence of bilateral tumors, we placed pregnant females from 129/SvJ Dnd1 Ter/+ intercross matings in a hypobaric chamber for 12-h intervals. Our results show that in 129/SvJ Dnd1 Ter/+ male gonads, the incidence of bilateral teratoma increased from 3.3% to 64% when fetuses were exposed to acute low oxygen conditions for 12-h between E13.8 and E14.3. The increase in tumor incidence correlated with the maintenance of high expression of pluripotency genes Oct4, Sox2 and Nanog, elevated activity of the Nodal signaling pathway, and suppression of germ cell mitotic arrest. We propose that the combination of heterozygosity for the Ter mutation and hypoxia causes a delay in male germ cell differentiation that promotes teratoma initiation.