Miracle-dz/UniFAR-FTUs huggingface dataset:
Türk ve İngiliz Üniversite Öğrencilerinin Duygularını Fark Etmeleri ve İfade Etmeleri ile Psikolojik İyi Oluşları Arasındaki İlişki

The aim of this study is to investigate how Turkish and English university students\' psychological well-being is predicted by the emotional awareness and expression of emotions. The research is a descriptive study. The Turkish group of the research was 349 Turkish university students educated at Gazi University in 2010-2011. The English group was 251 English university students. 229 of these were students at University College of London, University of London or Middelesex University in 2010-2011; 19 of these students were participated in the online research which was addressed as www.mediko. gazi.edu. tr/survey. Toronto-Alexithymia 20 Scale (Bagby, Parker and Taylor, 1994; Bestepe, 1997), Psychological well-being Scale (Ryff, 1989; Cenkseven, 2004), and Personal Information Form were used to collect data. Pearson – Moment Correlation and regression analysis were used for analyse. The results of regression analyses showed emotional awareness and expression of emotions predicted psychological well-being. The results were evaluated in terms of literature and institutional prospect; the suggestions were made by considering the future research and practical implication for counseling services.
LoRa from the City to the Mountains: Exploration of Hardware and Environmental Factors

LoRa technology is an increasingly popular option for applications that can exploit its low power and long range capabilities. While most efforts to date have studied its characteristics for smart city environments, we take LoRa outside the city limits, exploring how the environment affects its core communication properties. Specifically, we offer two novel parameter explorations to understand first how vegetation affects communication range and second how antennas change radio behavior. Our results provide insight into LoRa in non-urban environments, specifically showing that vegetation dramatically reduces the communication range and that the antenna selection can have a profound effect.
Sustainable Development in a Globalizing World: A Few Cautions

This article takes the view that in a globalizing context the concept of ‘sustainable development’ should not be assumed uncritically. Further, tensions arise when education is constructed as an instrument for the implementation of this concept, as manifest in the term ‘education for sustainable development’. With critical concern about sustainable development and the tensions arising out of an agenda of educational determinism, this article presents a series of cautions about education for sustainable development. While much good work is being done by educators who work under the label ‘sustainable development’, I argue in the end that education should provide the capacity to transcend this particular conception – to reach outside and beyond sustainable development.
How Multilingual Digital Information Is Used: A Study in Chinese Academic Libraries

Digital library, because of its resource demanding and other issues to solve, is an important application of multilingual information access (MLIA). However, the requirements of MLIA systems and applications are not typically addressed or assessed in our evaluations of digital libraries. This paper, therefore, aims to study the usages of MLIA in Chinese academic digital libraries. We conducted some surveys to study MLIA in current Chinese academic digital libraries and to get to know the users' real requirements for MLIA in Chinese academic digital libraries. The initial results offer thoughts on specific MLIA functions and insights on future digital library design and developments.
Recognizable and Rational Picture Series ?

The theory of two-dimensional languages as a generalization of formal string languages was motivated by problems arising from image processing and pattern recognition and also concerns models of parallel computing. Here we investigate power series on pictures and assign weights to different devices, ranging from tiling systems to picture automata. We will prove that, for commutative semirings, the behaviours of weighted picture automata are precisely alphabetic projections of series defined in terms of rational operations and also coincide with the families of series characterized by weighted tiling or weighted domino systems. Thus we obtain a robust definition of recognizable picture series. The theory of two-dimensional languages is obtained when restricting to the boolean semiring. These new equivalent weighted picture devices can be used to model several interesting application-examples, e.g. the intensity of light of a picture (interpreting the alphabet as different levels of gray) or the maximal amplitude of a monochrome subpicture of a colored picture.
ANALYSIS OF SOFT PLAQUE DETECTION METHODS IN CTA IMAGES

Cardiovascular diseases are considered primary cause for increasing rate of mortality. Automatic stenosis detection in CTA data is highly demanded by clinicians to analyze the coronary related abnormalities timely. The detection of vulnerable plaques in CTA is challenging because these plaques may exhibit similar appearance to nearby blood and muscle tissues. Moreover, accuracy of stenosis detection heavily depends upon the accuracy of delineation process of coronary arteries. In this paper, we present a comparative study of four different soft plaque detection methods along with their specific strengths and limitations. We have created a table summarizing the comparison of four selected methods against such criteria as imaging modality, segmentation method, level of pre and post processing, user interaction, validation of results, usage of prior knowledge, and effectiveness of segmentation and stenosis detection. The study provides assistance in selecting an appropriate method for detecting vulnerable coronary plaques, suitable for a given segmentation of coronary arteries.
Advances in the delivery of treatments for Parkinson’s disease

Innovative drug delivery in Parkinson’s disease (PD) has the potential to reduce or avoid many side effects of current treatment, such as wearing-off type fluctuations, dyskinesia, on-off phenomena or bouts of motor freezing. The traditional orally administered formulations of l-dihydroxyphenylalanine combined with a peripheral aromatic acid decarboxylase inhibitor remain the mainstay of treatments for PD. However, such combination therapies have been further formulated to extend their duration of action by including a catechol-O-methyltransferase inhibitor. Preventing the breakdown of dopamine has also been achieved by monoamine oxidase-B inhibition; this approach now having been formulated for sublingual use (Zelapar®, Valeant Pharmaceuticals). An alternative approach bypasses the oral route of administration and instead relies on continuous duodenal infusion (Duodopa®, Solvay, NeoPharma AB) for better therapeutic effect. The clinical use of dopamine agonists as antiparkinsonian drugs now incorporates a variety of delivery techniques. For example, apomorphine, which relies on parenteral administration for maximum bioavailability, may be delivered via rectal, intranasal, sublingual and subcutaneous (e.g., Apokyn®, Mylan Bertek) routes. Meanwhile, rotigotine and lisuride have both been formulated for delivery via skin patches. Finally, the authors examine more experimental delivery techniques, including the delivery of genes via viral vectors or liposomes, intracranial transplant of a variety of cells and of l-dihydroxyphenylalanine by prodrug-dispensing liposomes or pulmonary delivery (AIR®, Alkermes). The advent and application of these varied technologies will help encourage patient-specific means of treatment for PD.
Delivery of Encapsulated Doxorubicin by Ultrasound-Mediated Size Reduction of Drug-Loaded Polymer Contrast Agents

Low delivery efficiency combined with systemic toxicity of traditional chemotherapy provides a need for improved chemotherapeutic delivery. Within our laboratory, we have developed polymer ultrasound contrast agents (1.2-1.8 ¿m in diameter) containing doxorubicin (Dox) within the shell (100-150 nm). In vivo this platform is expected to circulate through the vasculature until activated at the tumor site with external focused ultrasound (US). In vitro, the agent is responsive to US and when insonated at peak positive pressure amplitudes of 0.69 MPa and above, shows dramatic size reduction, eventually reaching a mean particle size of 350 nm, presumably due to fragmentation of, or gas release from the agent. The resulting Dox-polymer particles retain the drug and are small enough to pass through the leaky pores (350-400 nm) within the tumor vasculature, providing a sustained intratumoral release of chemotherapeutic as the polymer degrades. In vivo studies using a VX2 liver tumor model have shown that the combination of the agent and US results in nearly 50% less drug delivered to the nontargeted, healthy liver ( p = 0.009) and a 110% increase (p = 0.004) in Dox delivery to the viable peripheral tissue of the tumor, relative to the uninsonated controls. This study shows how US-mediated destruction of drug-loaded polymer contrast agent can be used to deliver encapsulated drug for potential sustained release. Penetration mechanisms of these resulting particles and their ability to provide a sustained release from the tumor interstia will be explored in the future.
Towards Commercial Production of Sponge Medicines

Sponges can provide potential drugs against many major world-wide occurring diseases. Despite the high potential of sponge derived drugs no sustainable production method has been developed. Thus far it is not fully understood why, when, where and how these metabolites are produced in sponges. For the near future sea-based sponge culture seems to be the best production method. However, for controlled production in a defined system it is better to develop in vitro production methods, like in vitro sponge culture or even better sponge cell culture, culture methods for symbionts or the transfer of production routes into another host. We still have insufficient information about the background of metabolite production in sponges. Before production methods are developed we should first focus on factors that can induce metabolite production. This could be done in the natural habitat by studying the relation between stress factors (such as predation) and the production of bioactive metabolites. The location of production within the sponge should be identified in order to choose between sponge cell culture and symbiont culture. Alternatively the biosynthetic pathways could be introduced into hosts that can be cultured. For this the biosynthetic pathway of metabolite production should be unraveled, as well as the genes involved. This review discusses the current state of sponge metabolite production and the steps that need to be taken to develop commercial production techniques. The different possible production techniques are also discussed.
An Agent-Based Web Service Workflow Model

To improve the efficiency of Web service integration, an agent-based Web service workflow (ABWSWF) model is proposed. ABWSWF model contains three layers. The top is the user layer which represents the service requirements as goals, the bottom service layer denotes the distributed Web services, and the middle is the agent layer. Each service agent in the agent layer abstracts the features of a group of actual operations with similar functions as operation templates and models the process of using the operation templates to achieve a certain goal as plan. The application of the agent layer shields the heterogeneity of underling distributed Web services with similar functions. Therefore, the common users only need to focus on what they want to achieve rather than how to achieve. ABWSWF model has great flexibility and extensibility and offers guidance for developing efficient tools for Web service integration.
Modeling of activated sludge process using various nonlinear techniques: a comparison study

This paper presents a comparison study between radial basis function neural network (RBFNN), feed forward multilayer perceptron neural network (MLPNN) and adaptive neuro-fuzzy (ANFIS) technique to model the activated sludge process (ASP). All of these techniques are based on the nonlinear autoregressive with eXogenous input (NARX) structure. The ASP inputs and outputs data are generated from activated sludge model 1 (ASM1). This work will cover the dissolved oxygen (DO), substrate and biomass modeling. The performances of the model are evaluated based on R2, mean square error (MSE) and root mean square error RMSE. The simulation result shows that ANFIS with NARX structure given a better performance compared with the other modeling techniques.
Renal Activity of Akt Kinase in Obese Zucker Rats

Insulin resistance (IR) and consequent hyperinsulinemia are hallmarks of Type 2 diabetes (DM2). Akt kinase (Akt) is an important molecule in insulin signaling, implicated in regulation of glucose uptake, cell growth, cell survival, protein synthesis, and endothelial nitric oxide (NO) production. Impaired Akt activation in insulin-sensitive tissues contributes to IR. However, Akt activity in other tissues, particularly those affected by complications of DM2, has been less studied. We hypothesized that hyperinsulinemia could have an impact on activity of Akt and its effectors involved in regulation of renal morphology and function in DM2. To address this issue, renal cortical Akt was determined in obese Zucker rats (ZO), a model of DM2, and lean controls (ZL). We also studied expression and phosphorylation of the mammalian target of rapamycin (mTOR) and endothelial NO synthase (eNOS), molecules downstream of Akt in the insulin signaling cascade, and documented modulators of renal injury. Akt activity was measured by a kinase assay with GSK-3 as a substrate. Expression of phosphorylated (active) and total proteins was measured by immunoblotting and immunohistochemistry. Renal Akt activity was increased in ZO as compared to ZL rats, in parallel with progressive hyperinsulinemia. No differences in Akt were observed in the skeletal muscle. Corresponding to increases in Akt activity, ZO rats demonstrated enhanced phosphorylation of renal mTOR. Acute PI3K inhibition with wortmannin (100 μg/kg) attenuated renal Akt and mTOR activities in ZO, but not in ZL rats. In contrast to mTOR, eNOS phosphorylation was similar in ZO and ZL rats, despite higher total eNOS expression. In conclusion, ZO rats demonstrated increases in renal Akt and mTOR activity and expression. However, eNOS phosphorylation did not follow this pattern. These data suggest that DM2 is associated with selective IR in the kidney, allowing pro-growth signaling via mTOR, whereas potentially protective effects mediated by eNOS are blunted.
Group process and conflict in system development

Information system development projects engage organizational members in a process with potential for conflict. Managing such conflicts in project groups is an important but often neglected aspect of systems development. This research assesses group process during the development of an information system in an insurance company, using questionnaires, recorded transcripts of group meetings, interviews, and archival data. We describe the relationships among four variables in a model of conflict---participation, influence, conflict, and conflict resolution---at five different periods over a 22-month period. Our results show that in every time period participation positively affected influence and that influence positively affected both conflict and conflict resolution. These findings are supported by an analysis of communication patterns within four project meetings and by qualitative data collected during the project. The practical implications of conflict and group processes in system development are discussed.
Defining the Heart and Cardiovascular O-GlcNAcome: A Review of Approaches and Methods

The modification of nuclear, cytoplasmic, and mitochondrial proteins by monosaccharides of O-linked β-N-acetylglucosamine (O-GlcNAc) was first reported in 1984.1,2 Recent proteomic screens suggest that >1000 proteins in the cell are modified by O-GlcNAc3–10 and that these O-GlcNAc–modified proteins fall into many functional groups, including transcription factors and polymerases, cytoskeletal proteins, kinases and phosphatases, metabolic enzymes, ribosomal proteins, proteasomal proteins, and viral proteins.3–10 Not surprisingly, deletion of the O-GlcNAc transferase (OGT), the enzyme that adds O-GlcNAc, is lethal in mice at E4.5 and in isolated embryonic fibroblasts.11,12 O-GlcNAc is thought to regulate protein function in a manner analogous to protein phosphorylation,13 and like protein phosphorylation, levels of the O-GlcNAc protein modification, or O-GlcNAcylation, respond to numerous signals, including cellular damage, such as that caused by ischemia-reperfusion injury.13,14 Importantly, for a subset of proteins, O-GlcNAc and phosphorylation appear to be reciprocal, because the site of O-GlcNAcylation and phosphorylation is the same or, alternatively, the sites are proximal to each other.13 Supporting a model in which proteins are dynamically cycled between O-GlcNAcylated and phosphorylated states, the O-GlcNAc transferase is found in a complex with protein phosphatases.13,15 Unlike protein phosphorylation, the addition and removal of O-GlcNAc is catalyzed by just 2 enzymes, the O-GlcNAcase (removes O-GlcNAc) and the O-GlcNAc transferase (adds O-GlcNAc). 13 The high-energy sugar donor used by OGT is UDP-GlcNAc. A fraction (2–5% in adipocytes) of glucose imported into the cell is converted to UDP-GlcNAc through the hexosamine biosynthetic pathway; as such, O-GlcNAc is thought to be an effector of glucose, as well as glutamine and glucosamine (Figure 1). 13 These observations, and other studies, have led to the idea that elevated levels of O-GlcNAc are involved in mediating some of …
Capacity Limits of Multiple Antenna Multicast

The multiple antenna multicast channel is considered, in which the transmitter, equipped with an antenna array, sends a common message to multiple receivers, each of which are assumed to have only a single antenna. The information theoretic capacity of this channel is studied, along with the rates achievable using lower complexity transmission schemes. The primary focus of the paper is on the scaling of the capacity and achievable rates as the number of antennas and/or users is taken to infinity
Real-time diffuse global illumination using radiance hints

GPU-based interactive global illumination techniques are receiving an increasing interest from both the research and the industrial community as real-time graphics applications strive for visually rich and realistic dynamic three-dimensional environments. This paper presents a fast new diffuse global illumination method that generates a sparse set of low-cost radiance field evaluation points (radiance hints) and computes an arbitrary number of diffuse inter-reflections within a given volume. The proposed approximate technique combines ideas from exiting grid-based radiance caching techniques with reflective shadow maps as well as a stochastic scheme for visibility calculations, in order to achieve high frame rates for multiple light bounces.
SpoVID Guides SafA to the Spore Coat inBacillus subtilis

ABSTRACT Bacteria assemble complex structures by targeting proteins to specific subcellular locations. The protein coat that encasesBacillus subtilis spores is an example of a structure that requires coordinated targeting and assembly of more than 24 polypeptides. The earliest stages of coat assembly require the action of three morphogenetic proteins: SpoIVA, CotE, and SpoVID. In the first steps, a basement layer of SpoIVA forms around the surface of the forespore, guiding the subsequent positioning of a ring of CotE protein about 75 nm from the forespore surface. SpoVID localizes near the forespore membrane where it functions to maintain the integrity of the CotE ring and to anchor the nascent coat to the underlying spore structures. However, it is not known which spore coat proteins interact directly with SpoVID. In this study we examined the interaction between SpoVID and another spore coat protein, SafA, in vivo using the yeast two-hybrid system and in vitro. We found evidence that SpoVID and SafA directly interact and that SafA interacts with itself. Immunofluorescence microscopy showed that SafA localized around the forespore early during coat assembly and that this localization of SafA was dependent on SpoVID. Moreover, targeting of SafA to the forespore was also dependent on SpoIVA, as was targeting of SpoVID to the forespore. We suggest that the localization of SafA to the spore coat requires direct interaction with SpoVID.
Rhythmic movements are larger, faster but with the same frequency upon removal of visual feedback

The brain controls rhythmic movement through neural circuits combining visual information with proprioceptive information from the limbs. While rhythmic movements are fundamental to everyday activities, the specifics of the responsible control mechanisms remain elusive. We tested 39 young adults who performed flexion/extension movements of the forearm. We provided them with explicit knowledge of the amplitude and the speed of their movements, while frequency information was only implicitly available. In a series of three experiments, we demonstrate a tighter control of frequency compared with amplitude or speed. We found that in the absence of visual feedback, movements have larger amplitude and higher peak speed, while maintaining the same frequency as when visual feedback was available; this was the case even when participants were aware of performing overly large and fast movements. Finally, when participants were asked to continuously modulate movement frequency, but not amplitude, we found the local coefficient of variability of movement frequency to be lower than that of amplitude. We suggest that a misperception of the generated amplitude in the absence of visual feedback, coupled with a highly accurate perception of generated frequency leads to the performance of larger and faster movements, with the same frequency when visual feedback is not available. Relatively low local coefficient of variability of frequency in a task that calls for continuous change in movement frequency suggests that we tend to operate at a constant frequency at the expense of variation in amplitude and peak speed. 
ChromoZoom: a flexible, fluid, web-based genome browser

Summary: Current web-based genome browsers require repetitious user input to scroll over long distances, alter the drawing density of elements or zoom through multiple orders of magnitude. Generally, either the server or the client is responsible for the majority of data processing, resulting in either servers having to receive and handle data relevant only to one user, or clients redundantly processing widely viewed data. ChromoZoom pre-renders and caches general-use tracks into tiled images on the server and serves them in an interactive web interface with inertial scrolling and precise, fluent zooming via the mouse wheel or trackpad. Custom tracks in several formats can be rendered by client-side code alongside the pre-rendered tracks, minimizing server load because of user-specific rendering and eliminating the need to transmit private data. ChromoZoom thereby enables rapid and simultaneous exploration of curated, experimental and personal genomic datasets. Availability: Human and yeast genome researchers may browse recent assemblies within ChromoZoom at http://chromozoom.org/. Source code is available at http://github.com/rothlab/chromozoom/. Contact: fritz.roth@utoronto.ca Supplementary information: Supplementary data are available at Bioinformatics online.