Miracle-dz/UniFAR-FTUs huggingface dataset:
Transmission of family businesses in France

Purpose – The purpose of this research paper is to show to what extent psychological, cultural and behavioural factors can influence on the succession process in the particular case of family‐run businesses? Design/methodology/approach – Data on 12 directors of family‐run SME were grouped together on the basis of questions derived from the research question. To do this, the authors operated using a principle guided by cross referencing responses, that is, finding the incidence of elements that make it possible to justify substantively the existence of the category and the common existence of these elements within the cases studied. Findings – The thematic analysis performed made it possible to highlight five main motives for cultural and psychological resistance in former directors: the loss of power and influence, the risk of deconstruction, the loss of professional and social legitimacy, the loss of references and meaning, and the refusal of old age and death. Originality/value – The results show that transferors search for connections in the aim of identifying common points of anchor, affinities on to which they can project themselves as an element of continuity or an extension of their personality. The paper can in particular note the importance given to cultural proximity and to previous professional relations with the transferor. These criteria, unlike personal factors, are of the interpersonal type and thus deeply imprinted on the transferor's most intimate desires and motivations, including the main desire, which is to search for all that can make possible an extension of himself within his company and thus ensure the permanence of his values and his time at the organisation.
Adipose Triglyceride Lipase and Hormone-sensitive Lipase Are the Major Enzymes in Adipose Tissue Triacylglycerol Catabolism*

The mobilization of free fatty acids from adipose triacylglycerol (TG) stores requires the activities of triacylglycerol lipases. In this study, we demonstrate that adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) are the major enzymes contributing to TG breakdown in in vitro assays and in organ cultures of murine white adipose tissue (WAT). To differentiate between ATGL- and HSL-specific activities in cytosolic preparations of WAT and to determine the relative contribution of these TG hydrolases to the lipolytic catabolism of fat, mutant mouse models lacking ATGL or HSL and a mono-specific, small molecule inhibitor for HSL (76-0079) were used. We show that 76-0079 had no effect on TG catabolism in HSL-deficient WAT but, in contrast, essentially abolished free fatty acid mobilization in ATGL-deficient fat. CGI-58, a recently identified coactivator of ATGL, stimulates TG hydrolase activity in wild-type and HSL-deficient WAT but not in ATGL-deficient WAT, suggesting that ATGL is the sole target for CGI-58-mediated activation of adipose lipolysis. Together, ATGL and HSL are responsible for more than 95% of the TG hydrolase activity present in murine WAT. Additional known or unknown lipases appear to play only a quantitatively minor role in fat cell lipolysis.
A Hybrid Approach for Gender Classification of Web Images

In recent times, gender recognition of facial images has achieved lots of attraction. It can be useful in many places e.g. security, web searching, human computer interaction etc. In this paper, an approach containing both face detection and gender classification tasks has been proposed. In face detection part, Haar features have been chosen to present appearance features along with Ada-Boost technique to target strong and powerful features in cascaded form. For gender classification, Bayesian Classifier has been used where image is analyzed in blocks/patches form. The blocking technique is same as used in DCT approach. Experimental results have shown that proposed approach is effective and robust with changes in pose (some degree), expressions and illumination.
FREEDOM, POWER AND CAPITALISM: FROM DISCIPLINES TO BIOPOWER

In this paper I propose a framework to understand the transition in Foucault’s work from the disciplinary model to the governmentality model. Foucault’s work on power emerges within the general context of an expression of capitalist rationality and the nature of freedom and power within it. I argue that, thus understood, Foucault’s transition to the governmentality model can be seen simultaneously as a deepening recognition of what capitalism is and how it works, but also as a recognition of the changing historical nature of the actually existing capitalisms and their specifically situated historical needs. I then argue that the disciplinary model should be understood as a contingent response to the demands of early capitalism, and argue that with the maturation of the capitalist enterprise many of those responses are no longer necessary. New realities require new responses; although this does not necessarily result in the abandonment of the earlier disciplinary model, it does require their reconfiguration according to the changed situation and the new imperatives following from it.
Hepatitis C Virus Induces Proteolytic Cleavage of Sterol Regulatory Element Binding Proteins and Stimulates Their Phosphorylation via Oxidative Stress

ABSTRACT Hepatic steatosis is a common histological feature of chronic hepatitis C. Hepatitis C virus (HCV) gene expression has been shown to alter host cell cholesterol/lipid metabolism and thus induce hepatic steatosis. Since sterol regulatory element binding proteins (SREBPs) are major regulators of lipid metabolism, we sought to determine whether genotype 2a-based HCV infection induces the expression and posttranslational activation of SREBPs. HCV infection stimulates the expression of genes related to lipogenesis. HCV induces the proteolytic cleavage of SREBPs. HCV core and NS4b derived from genotype 3a are also individually capable of inducing the proteolytic processing of SREBPs. Further, we demonstrate that HCV stimulates the phosphorylation of SREBPs. Our studies show that HCV-induced oxidative stress and subsequent activation of the phosphatidylinositol 3-kinase (PI3-K)-Akt pathway and inactivation (phosphorylation) of PTEN (phosphatase and tensin homologue) mediate the transactivation of SREBPs. HCV-induced SREBP-1 and -2 activities were sensitive to antioxidant (pyrrolidine dithiocarbamate), Ca2+ chelator 1,2-bis(aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid-tetra(acetoxymethyl) ester (BAPTA-AM), and PI3-K inhibitor (LY294002). Collectively, these studies provide insight into the mechanisms of hepatic steatosis associated with HCV infection.
Anxiety- and Depression-Related Thoughts in Children: Development and Evaluation of a Cognition Measure

This study examined anxiety- and depression-related cognitive content in children. We developed the Children's Thought Questionnaire (CTQ) to include anxious thoughts characterized by threat and uncertainty; depressive thoughts by loss, self-deprecation, and certainty/hopelessness; and positive thoughts by interest, pleasure, and positive self-reference. The CTQ and measures of anxious and depressive symptoms were completed by 193 5th- and 6th-grade children. Exploratory factor analysis of the CTQ revealed that items loaded on 2 factors according to negative and positive valence. However, use of conceptually derived subscales demonstrated specificity, with higher levels of anxious thoughts uniquely predicting greater anxious symptoms and higher depressive thoughts uniquely predicting greater depressive symptoms. Furthermore, positive thoughts were negatively related to depressive symptoms but either unrelated or positively related to anxious symptoms, thus providing support for cognitive specificity.
Early On-Treatment Viral Load and Baseline Metavir Score: Improved Prediction of Sustained Virological Response in HCV Genotype 1 Patients

Background On-treatment HCV viral load during early therapy with pegylated interferon (PEG-IFN) and ribavirin is highly predictive of sustained virological response (SVR). We sought to provide further refinement of this prediction through an extensive evaluation of the effect of HCV viral loads at weeks 4, 8 and 12 on SVR, including analysis by liver disease stage grouping. Methods A total of 309 patients with genotype 1 chronic HCV and recent liver biopsy enrolled in the CHARIOT study received 180 μg of PEG-IFN-α2a weekly with 1,000/1,200 mg of ribavirin daily. The probability of an SVR was estimated using baseline METAVIR fibrosis stage and HCV viral loads at weeks 4, 8 and 12. Results HCV RNA was undetectable in 27.5%, 50.3% and 62.6% of patients at weeks 4, 8 and 12, respectively. SVR was 80.0%, 76.8% and 72.4% among patients with undetectable HCV RNA at weeks 4, 8 and 12, respectively. SVR decreased in a progressive fashion with increasing HCV viral loads at each early time point, but was similar for patients with HCV viral load <15 IU/ml, 15–100 IU/ml and 100–1,000 IU/ml. The effect of fibrosis stage on SVR was modest for patients with HCV viral load <1,000 IU/ml at week 4, but more marked for those with week 4 HCV viral load >1,000 IU/ml, and all HCV viral load categories at weeks 8 and 12. Conclusions A combination of baseline fibrosis stage and on-treatment HCV viral load at early time points provides improved estimates for treatment response in patients with chronic HCV genotype 1.
Identification of Novel NPRAP/δ-Catenin-Interacting Proteins and the Direct Association of NPRAP with Dynamin 2

Neural plakophilin-related armadillo protein (NPRAP or δ-catenin) is a neuronal-specific protein that is best known for its interaction with presenilin 1 (PS1). Interestingly, the hemizygous loss of NPRAP is associated with severe mental retardation in cri du chat syndrome (CDCS), and mutations in PS1 cause an aggressive, early-onset form of Alzheimer's disease. Until recently, studies on the function of NPRAP have focused on its ability to modulate dendritic protrusion elaboration through its binding to cell adhesion and scaffolding molecules. However, mounting evidence indicates that NPRAP participates in intracellular signaling and exists in the nucleus, where it modulates gene expression. This apparent bifunctional nature suggests an elaborate neuronal role, but how NPRAP came to participate in such distinct subcellular events remains a mystery. To gain insight into this pathway, we immunoprecipitated NPRAP from human SH SY5Y cells and identified several novel interacting proteins by mass spectrometry. These included neurofilament alpha-internexin, interferon regulatory protein 2 binding factors, and dynamins 1 and 2. We further validated dynamin 2/NPRAP colocalization and direct interaction in vivo, confirming their bona fide partnership. Interestingly, dynamin 2 has established roles in endocytosis and actin assembly, and both of these processes have the potential to interface with the cell adhesion and intracellular signaling processes that involve NPRAP. Our data provide new avenues for approaching NPRAP biology and suggest a broader role for this protein than previously thought.
Solving deceptive tasks in robot body-brain co-evolution by searching for behavioral novelty

Evolutionary algorithms are a frequently used technique for designing morphology and controller of a robot. However, a significant challenge for evolutionary algorithms is premature convergence to local optima. Recently proposed Novelty Search algorithm introduces a radical idea that premature convergence to local optima can be avoided by ignoring the original objective and searching for any novel behaviors instead. In this paper, we apply novelty search to the problem of body-brain co-evolution. We demonstrate that novelty search significantly outperforms fitness-based search in a deceiving barrier avoidance task but does not provide an advantage in the swimming task where a large unconstrained behavior space inhibits its efficiency. Thus, we show that the advantages of novelty search previously demonstrated in other domains can also be utilized in the more complex domain of body-brain co-evolution, provided that the task is deceiving and behavior space is constrained.
Multidimensional Region Connection Calculus

The best way to support commonsense reasoning over geographic data is via qualitative spatial reasoning over spatial objects and their relations. The Region Connection Calculus (RCC) (Randell et al. 1992) family is one of the well-known logical languages for formalizing topological relationships that describe commonsense spatial knowledge. In this paper, we modify and extend RCC-8 to propose a topological model accepting multi-dimension geometric features as an input. We will compare the model with the 9Intersection Model (9-IM) in our future work to show that our model offers more flexibility for geographic information systems (GIS).
Indoor broadcasting via white LEDs and OFDM

Recently, visible light communication (VLC) technology has been gaining attention in both academia and industry. This is driven by the progress of white light emitting diode (LED) technology for solid-state lighting (SSL) and the potential of simultaneously using such LEDs for illumination and indoor wireless data transmission. This paper provides an overview about the technology and describes the physical layer implementation of a VLC system based on a modified version of the classical orthogonal frequency division multiplexing (OFDM) modulation technique. Besides, the paper presents a hardware prototype for short-range broadcasting using a white LED lamp. The OFDM system runs on DSP development boards. Off-the-shelf 9 LEDs and a single photodiode (PD) are utilized to build the analog frontends. The prototype allows investigating the influence of the electrical signal-to-noise ratio (SNR), constellation order, and channel coding on the bit-error performance. Theoretical and experimental results on optical path loss show close match. In this context, the influence of the LED beam angle on the horizontal coverage is highlighted.
EYE MOVEMENT ANALYSIS IN VISUAL INSPECTION OF GEOSPATIAL DATA

Modern geospatial data acquisition systems deliver vast amounts of multi-domain remotely sensed data such as multi/hyper spectral imagery and LIDAR point-clouds. Unfortunately geospatial products automatically derived from source geospatial data are burdened with residual errors and artifacts which should be manually inspected, cleaned and corrected. These tasks become critical in many large-scale projects that require real-time processing of immense amounts of visual information and usually require manual post-processing or visual inspection of the source and/or derived data. The process of visual inspection could be divided in two general phases: perception and reaction. Scene perception comprises several steps such as visual search, feature selection and identification. Reaction reflects a decision made by an operator and usually involves other types of modalities (e.g. physical action such as mouse movements or typing). Human analysts perceive visual data through intensive movements of eyes which subconsciously select the most distinctive features in an image in order to reduce our overall ambiguity about the observed scene. A sequence of eye movements may then be understood within a framework of sequential accumulation of information. Whether or not all informative points are detected depends on both the observer’s current knowledge of the stimulus and the particular task. Dynamics of this information accrual process can be documented and quantified using analysis of eye movements during the process of natural, active visual perception. This paper presents theoretical and practical investigations that have been made to illustrate the feasibility of 3D gaze tracking as a disambiguation tool in the process of visual search of a target in high resolution imagery.
Changing Attitudes: A Teaching Initiative in the Medical School

In this paper we describe an innovatory teaching programme for medical students which is designed to promote more positive images of people with learning disabilities (L.D.). The programme involves small groups of medical students working in partnership with equal numbers of people with L.D. on a specific task of mutual interest. In educational terms, the programme was highly successful; students enjoyed the experience and found it both interesting and relevant to their medical studies. At the end of the programme students had acquired a greater respect for the abilities of people with L.D. and were more positively inclined towards them and their rights as citizens. However, the evidence also suggested that they continued to regard people with L.D. as somehow qualitatively different from non-handicapped people — less able, more dependent and child-like.
Spatio-textual spreadsheets: geotagging via spatial coherence

The spatio-textual spreadsheet is a conventional spreadsheet where spatial attribute values are specified textually. Techniques are presented to automatically find the textually-specified spatial attributes that are present in spreadsheets. Once the spatial attributes have been identified, an accurate translation of the values of the spatial attributes to their actual geographic locations is needed (known as geotagging). The key observation is that spreadsheets with spatial data exhibit spatial coherence --- that is, cells with spatial data that are nearby in the spreadsheet contain data that share spatial characteristics in the real world. These techniques also allow richer search engine results by returning actual tuples from spreadsheets instead of simply links to the spreadsheets. Moreover, when the search key is a particular location, results in proximity to the query can be provided rather than just exact matches.
Real-time environmental emission monitoring on construction sites

In recent years, there has been an increasing interest in wireless sensor networks for monitoring systems within the civil and structural engineering community. There has been not only research on wireless sensor networks for monitoring structural performance and health, but also on localization of building materials and construction machinery. Furthermore, wireless sensor networks are due to their potential of reducing wiring cost also recently investigated for monitoring disturbing emissions like air pollution, noise and hazardous ground vibrations. We propose a wireless sensor network system enabling long term and real-time monitoring of environmental parameters, to detect emissions on a construction site and ensure the compliance of maximum permissible values in real-time. In this novel approach we combine various sensors measuring specific environmental parameters (dust, noise, vibration, position, timestamps), a data acquisition unit, and a radio unit to directly transfer information to a data sink. We conclude that the proposed system offers great possibilities for future deployments at low cost.
"Your Job No Longer Exists!": From Expectations of Flexibility to Experiences of Alienation - A Phenomenological Study

We have entered the age of the contingent or temporary worker, the consultant and the subcontractor. Workers are expected to be pliable and tractable; to "fit in". The latest managerialist trend heralded to assist workers is, in reality, one that helps organisations at the expense of workers. Being made redundant is one area where workers are expected to be flexible and resilient. However, when these so-called "flexible" workers are told their job no longer exists, the accompanying sense of rejection and alienation can be excruciating. Stories of being made redundant were collected during an exploratory, qualitative study, using Heideggerian phenomenology as the methodological vehicle to capture the lived experiences of these individuals. Focused in-depth interviews were conducted with the ten respondents; nine men and one woman. The stories shared in this study suggest that being made redundant is a harrowing, alienating, painful and emotional experience. Respondents’ experiences revealed feelings of powerlessness, as well as shock, betrayal and shame. This is not an experience that people can bounce back from, unchanged. Respondents spoke of significant personal outcomes, including a resulting fear for the future. They also spoke of the adverse impact on their careers and an erosion of trust in organisations. The Putative "Flexible" Worker Flexible: 1. Able to be bent easily without breaking; pliable. 2. Adaptable or variable: flexible working hours. 3. Able to be persuaded easily; tractable. (Wilkes, 1979, p. 555) We have entered the age of the contingent or temporary worker, the consultant and the subcontractor. This is the "just-in-time workforce" 'fluid, flexible and disposable' (Micklethwait & Wooldridge, 1996, p. 212). Organisations are reducing the size of their workforces, moving work to parttime or temporary staff, and transferring various tasks and functions to contractors (Johnson, 2004, p. 723). Workers are expected to be pliable and tractable; to "fit in" with the latest managerialist trend heralded to assist workers while, in reality, this trend helps organisations at the expense of workers. The emphasis on flexible employees and temporary workforces has arisen among the continuing trend in the West towards worsening job security and conditions of service. The last twenty years have seen an escalation of organisational restructuring, downsizing and outsourcing. Responsibility for career development is being shifted back to employees (Iles, Forster &
A Cross-Site Analysis of Strategies Used by Three Middle School Art Teachers to Foster Student Learning2

This cross-site, collaborative study focused on the instructional practices of three middle school art teachers from Arizona, Indiana, and New York. The researchers found similarities as well as differences among the teachers' strategies. At all three sites, emphasis was on curriculum related to their students' lives, developing technical skills, visual perception, aesthetic judgment, and personal expression, and on evolving understandings about art heritages, selfidentity, diversity, and multicultural concerns, but curricular forms differed. All three teachers used state standards in curricular planning and conducted inprocess and final group assessments. Findings support the idea that social class context may have a greater influence than geographical location on the type and magnitude of art curricula developed in middle schools.
Through the drinking glass: an analysis of the cultural meanings of college drinking

College drinking and its adverse consequences on students' health and safety are important public health concerns in the USA. Thus far, there is little attention on exploring and addressing the cultural dimensions of college drinking. This study examines the construction of meaning of drinking among students to understand their perspectives of the college drinking culture. From an analysis of a purposive sample of 232 US college newspaper articles covering alcohol-related news and associated readers’ responses, the study identified five major insights in the cultural meanings of college drinking: (1) drinking is central to the US college experience although this can and should change; (2) drinking has significant social and functional meanings to students' identities; (3) heavy drinking derives from a culture of risk taking; (4) college drinking is highly scripted and ritualized; and (5) various social motives drive students' drinking. The first implication for practice and research of college drinking prevention is that a cultural lens viewing drinking as socially and developmentally meaningful may contribute toward theorizing why students continue to drink heavily despite decades of multi-level interventions. Second, approaches that respect and incorporate students' meaning making of drinking may be hypothesized as viable and effective alternatives to existing interventions for reducing risky drinking behaviors.