Miracle-dz/UniFAR-FTUs huggingface dataset:
Office‐Based Anesthesia: Safety and Outcomes in Pediatric Dental Patients

&NA; The number of children with caries requiring general anesthesia to achieve comprehensive dental care and the demand for dentist anesthesiologists to provide ambulatory anesthesia for these patients is increasing. No current published studies examine the safety and outcomes of ambulatory anesthesia performed by dentist anesthesiologists for dental procedures in pediatric patients, and there is no national requirement for reporting outcomes of these procedures. In 2010, the Society for Ambulatory Anesthesia Clinical Outcomes Registry was developed. This Web‐based database allows providers of ambulatory anesthesia to track patient demographics and various outcomes of procedures. Our study is a secondary analysis of data collected in the registry over a 4‐year period, 2010–2014. Of the 7041 cases reviewed, no cases resulted in serious complications, including death, anaphylaxis, aspiration, cardiovascular adverse events, or neurologic adverse events. Of the 7041 cases reviewed, 196 (3.0%) resulted in a predischarge or postdischarge adverse event. The predischarge adverse event occurring with the highest frequency was laryngospasm, occurring in 35 cases (0.50%). The postdischarge adverse event occurring with the highest frequency was nausea, reported by 99 patients (5.0%). This study provides strong clinical outcomes data to support the safety of office‐based anesthesia as performed by dentist anesthesiologists in the treatment of pediatric dental patients.
Adipose tissue cellularity and growth characteristics of unselected and selected broilers: implications for the development of body fat.

Chicks from large and small eggs were used to increase body weight range within samples of unselected Athens-Canadian (AC) and commercial Cobb (C) broilers. At 54 days of age, representatives of each sex and broiler stock obtained from the large and small eggs were killed. Indices of whole body, muscle, fat, and bone growth were taken. Samples of abdominal fat were fixed with osmium tetroxide for electronic quantification of adipocyte number and size distribution. Broiler stock, egg size, and sex affected all indices of muscle and bone growth on an absolute basis, but only broiler stock significantly affected abdominal fat pad development. Muscle and fat weight, expressed as a proportion of body weight, were larger in C broilers. Abdominal adipocyte number was greater in C than AC (126.0 +/- 10.0 vs. 90.9 +/- 7.7 million, P less than .01), but the greater adiposity of C was associated with an increase in adipocyte size. If the mean adipocyte volume of C (120.4 +/- 8.5 pl) was reduced to the mean adipocyte volume of AC (53.8 +/- 6.5 pl), proportional weight of the abdominal pad of C would have been smaller than proportional pad weight of AC. The problem of excessive abdominal fat deposition in the selected broiler stock appears related to factors that affect control of adipocyte size and body composition.
Capturing the Pulse of Cities: Opportunity and Research Challenges for Robust Stream Data Reasoning

In a Smarter City, available resources are harnessed safely, sustainably and efficiently to achieve positive, measurable economic and societal outcomes. Data and information from people, systems and things is the single most scalable resource available to city stakeholders but difficult to publish, organize, discover and consume, especially in a real-time context. Enabling city information as a utility, through a robust (expressive, dynamic, scalable) and (critically) a sustainable technology and socially synergistic ecosystem, could drive significant benefits and opportunities. In the context of stream data (as real-time, gigantic, noisy and private data), this paper targets research issues we identify as important to harness the fused information resources of cities, Citizens and Stakeholders to reach the concept of Smarter Cities.
When Textbook RSA is Used to Protect the Privacy of Hundreds of Millions of Users

We evaluate Tencent's QQ Browser, a popular mobile browser in China with hundreds of millions of users---including 16 million overseas, with respect to the threat model of a man-in-the-middle attacker with state actor capabilities. This is motivated by information in the Snowden revelations suggesting that another Chinese mobile browser, UC Browser, was being used to track users by Western nation-state adversaries. Among the many issues we found in QQ Browser that are presented in this paper, the use of "textbook RSA"---that is, RSA implemented as shown in textbooks, with no padding---is particularly interesting because it affords us the opportunity to contextualize existing research in breaking textbook RSA. We also present a novel attack on QQ Browser's use of textbook RSA that is distinguished from previous research by its simplicity. We emphasize that although QQ Browser's cryptography and our attacks on it are very simple, the impact is serious. Thus, research into how to break very poor cryptography (such as textbook RSA) has both pedagogical value and real-world impact.
Relationship between stereoacuity and motor skills of children with intellectual disabilities

The goal of this study was to determine the relationship between stereoacuity and proficiency in fine and gross motor skills. Stereovision is one of the information sources for accurate perception of objects in depth, and it is related to performance on motor skills tasks. Studies have shown that children of primary school age with mild intellectual disabilities perform worse than typically developing children on specific fine and gross motor skills. Also, problems in visual functioning, including impaired binocular vision (stereovision), are common in children with intellectual disability. We tested 27 children with intellectual disabilities but without any motor skills deficiency. Research was conducted at the Centre for Education "Velika Gorica" and Elementary School "Nad lipom". For this research, we constructed a Likert-type scale to assess fine and gross motor proficiency. We also tested stereoacuity using the Random Dot 2 Acuity Test with Lea Symbols®. Our results show a relationship between the degree of stereovision and level of proficiency in fine and gross motor skills. Since stereovision develops during preschool years and is related to other skills, we need to provide timely assessment of visual functioning and create specific program adaptations for children with intellectual disabilities.
Data Privacy for a ρ-Recoverable Function

A user's data is represented by a finite-valued random variable. Given a function of the data, a querier is required to recover, with at least a prescribed probability, the value of the function based on a query response provided by the user. The user devises the query response, subject to the recoverability requirement, so as to maximize privacy of the data from the querier. Privacy is measured by the probability of error incurred by the querier in estimating the data from the query response. We analyze single and multiple independent query responses, with each response satisfying the recoverability requirement, that provide maximum privacy to the user. Achievability schemes with explicit randomization mechanisms for query responses are given and their privacy compared with converse upper bounds.
Modelling the limits on the response of net carbon exchange to fertilization in a south-eastern pine forest

Using a combination of model simulations and detailed measurements at a hierarchy of scales conducted at a sandhills forest site, the effect of fertilization on net ecosystem exchange ( NEE ) and its components in 6-year-old Pinus taeda stands was quantified. The detailed measurements, collected over a 20-d period in September and October, included gas exchange and eddy covariance fluxes, sampled for a 10-d period each at the fertilized stand and at the control stand. Respiration from the forest floor and aboveground biomass was measured using chambers during the experiment. Fertilization doubled leaf area index (LAI) and increased leaf carboxylation capacity by 20%. However, this increase in total LAI translated into an increase of only 25% in modelled sunlit LAI and in canopy photosynthesis. It is shown that the same climatic and environmental conditions that enhance photosynthesis in the September and October periods also cause an increase in respiration The increases in respiration counterbalanced photosynthesis and resulted in negligible NEE differences between fertilized and control stands. The fact that total biomass of the fertilized stand exceeded 2·5 times that of the control, suggests that the counteracting effects cannot persist throughout the year. In fact, modelled annual carbon balance showed that gross primary productivity ( GPP ) increased by about 50% and that the largest enhancement in NEE occurred in the spring and autumn, during which cooler temperatures reduced respiration more than photosynthesis. The modelled difference in annual NEE between fertilized and control stands (approximately 200 g C m − 2 y − 1 ) suggest that the effect of fertilization was sufficiently large to transform the stand from a net terrestrial carbon source to a net sink.
Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids

Hypertrophic scars and keloids are fibroproliferative disorders that may arise after any deep cutaneous injury caused by trauma, burns, surgery, etc. Hypertrophic scars and keloids are cosmetically problematic, and in combination with functional problems such as contractures and subjective symptoms including pruritus, these significantly affect patients’ quality of life. There have been many studies on hypertrophic scars and keloids; but the mechanisms underlying scar formation have not yet been well established, and prophylactic and treatment strategies remain unsatisfactory. In this review, the authors introduce and summarize classical concepts surrounding wound healing and review recent understandings of the biology, prevention and treatment strategies for hypertrophic scars and keloids.
Model of physiological stress in chickens 5. Quantitative evaluation.

Physiological stress was studied in broilers using a new model employing continuous release of adrenocorticotropin (ACTH). A total of 42 adaptive response parameters were evaluated. A treatment response ratio, P-value transformation, and stress score were determined for each parameter. The treatment response ratio was calculated by dividing the maximum response of the ACTH-treated birds for each parameter by the average response of control (CON) birds in all cases in which maximum response of ACTH-treated birds exceeded the average response of CON. This treatment response ratio is designated hereafter as ACTH/CON ratio. In those cases in which average response of CON exceeded maximum response of ACTH-treated birds, the reciprocal equation was employed (i.e., CON/ACTH ratio). Probability value transformations were determined by transforming P-values as follows: NS P-values or those exhibiting significance at values less than probability of 5% were expressed as P<0.05 = 1, P-values exhibiting significance between 0.05 and 0.02 were expressed as P at 0.05 to 0.02 = 2, and P-values exhibiting significance at probabilities of 1% or less were P<0.01 = 4. Each stress score was calculated as treatment response ratio times P-value transformation. The 42 response parameters were assigned to one of four adaptive categories, and these were morphologic, endocrine, and blood metabolites; digestion and metabolism; and reticuloendothelial responses. The endocrine and blood metabolites category had the highest average of the four stress response categories, and five of the top ten parameters were found in this category.
Supporting ESL Writing by Prompting Crowdsourced Structural Feedback

Writing is challenging, especially for non-native speakers. To support English as a Second Language (ESL) writing, we propose StructFeed, which allows native speakers to annotate topic sentence and relevant keywords in texts and generate writing hints based on the principle of paragraph unity. First, we compared our crowd-based method with three naive machine learning (ML) methods and got the best performance on the identification of topic sentence and irrelevant sentence in the article. Next, we evaluated the StructFeed system with two feedback-generation mechanisms including feedback generated by one expert and by one crowd worker. The results showed that people who received feedback by StructFeed got the highest improvement after revision.
Effect of moisture and temperature on ability of Salmonellae to infect shell eggs.

Abstract Human salmonellosis is one of today’s major public health problems. Shell eggs have sometimes been responsible for food borne outbreaks of this illness (Philbrook et al., 1960; Bowmer, 1965 ; Adler, 1965). It is important that the means by which Salmonellae infect the egg be understood and prevented. For the purpose of this paper, the word “infect” shall mean to invade and proliferate in the egg contents to more than 1,000 viable cells per gram. Although Salmonellae can enter the egg from an infected ovary (Van Roekel, 1965; Board, 1966), the most common route of infection is considered to be by penetration through the shell (Mundt and Tugwell, 1958; Adler, 1965). The ability of Salmonellae to invade the egg shell has been demonstrated by Bigland and Papas (1953), Stokes et al. (1956), Brown et al. (1965), Rizk et al. (1966) and others. …
The effects of a pectic enzyme on the growth-depressing and rachitogenic properties of rye for chicks.

Rye has growth-depressing and rachitogenic properties when fed to chicks. Growth depression also is observed when chicks are fed certain polysaccharides, particularly pectin. Rye has about 8% pectin-like material. A commercially available pectic enzyme preparation was fed to chicks at . 1% of the rye diet. This enzyme permitted better utilization of rye for growth and also alleviated the rachitogenic effects of rye. The supplemental enzyme permitted maximal bone mineralization with 200 to 300 ICU of vitamin D3/kg diet, whereas 500 ICU/kg otherwise were required with rye diets.
Gonadal Hormones and Retinal Disorders: A Review

Aim Gonadal hormones are essential for reproductive function, but can act on neural and other organ systems, and are probably the cause of the large majority of known sex differences in function and disease. The aim of this review is to provide evidence for this hypothesis in relation to eye disorders and to retinopathies in particular. Methods Epidemiological studies and research articles were reviewed. Results Analysis of the biological basis for a relationship between eye diseases and hormones showed that estrogen, androgen, and progesterone receptors are present throughout the eye and that these steroids are locally produced in ocular tissues. Sex hormones can have a neuroprotective action on the retina and modulate ocular blood flow. There are differences between the male and the female retina; moreover, sex hormones can influence the development (or not) of certain disorders. For example, exposure to endogenous estrogens, depending on age at menarche and menopause and number of pregnancies, and exposure to exogenous estrogens, as in hormone replacement therapy and use of oral contraceptives, appear to protect against age-related macular degeneration (both drusenoid and neurovascular types), whereas exogenous testosterone therapy is a risk factor for central serous chorioretinopathy. Macular hole is more common among women than men, particularly in postmenopausal women probably owing to the sudden drop in estrogen production in later middle age. Progestin therapy appears to ameliorate the course of retinitis pigmentosa. Diabetic retinopathy, a complication of diabetes, may be more common among men than women. Conclusion We observed a correlation between many retinopathies and sex, probably as a result of the protective effect some gonadal hormones may exert against the development of certain disorders. This may have ramifications for the use of hormone therapy in the treatment of eye disease and of retinal disorders in particular.
Rapid, ultra low coverage copy number profiling of cell-free DNA as a precision oncology screening strategy

Current cell-free DNA (cfDNA) next generation sequencing (NGS) precision oncology workflows are typically limited to targeted and/or disease-specific applications. In advanced cancer, disease burden and cfDNA tumor content are often elevated, yielding unique precision oncology opportunities. We sought to demonstrate the utility of a pan-cancer, rapid, inexpensive, whole genome NGS of cfDNA approach (PRINCe) as a precision oncology screening strategy via ultra-low coverage (~0.01x) tumor content determination through genome-wide copy number alteration (CNA) profiling. We applied PRINCe to a retrospective cohort of 124 cfDNA samples from 100 patients with advanced cancers, including 76 men with metastatic castration-resistant prostate cancer (mCRPC), enabling cfDNA tumor content approximation and actionable focal CNA detection, while facilitating concordance analyses between cfDNA and tissue-based NGS profiles and assessment of cfDNA alteration associations with mCRPC treatment outcomes. Therapeutically relevant focal CNAs were present in 42 (34%) cfDNA samples, including 36 of 93 (39%) mCRPC patient samples harboring AR amplification. PRINCe identified pre-treatment cfDNA CNA profiles facilitating disease monitoring. Combining PRINCe with routine targeted NGS of cfDNA enabled mutation and CNA assessment with coverages tuned to cfDNA tumor content. In mCRPC, genome-wide PRINCe cfDNA and matched tissue CNA profiles showed high concordance (median Pearson correlation = 0.87), and PRINCe detectable AR amplifications predicted reduced time on therapy, independent of therapy type (Kaplan-Meier log-rank test, chi-square = 24.9, p < 0.0001). Our screening approach enables robust, broadly applicable cfDNA-based precision oncology for patients with advanced cancer through scalable identification of therapeutically relevant CNAs and pre-/post-treatment genomic profiles, enabling cfDNA- or tissue-based precision oncology workflow optimization.
Genome sequence and physiological analysis of Yamadazyma laniorum f.a. sp. nov. and a reevaluation of the apocryphal xylose fermentation of its sister species, Candida tenuis

&NA; Xylose fermentation is a rare trait that is immensely important to the cellulosic biofuel industry, and Candida tenuis is one of the few yeasts that has been reported with this trait. Here we report the isolation of two strains representing a candidate sister species to C. tenuis. Integrated analysis of genome sequence and physiology suggested the genetic basis of a number of traits, including variation between the novel species and C. tenuis in lactose metabolism due to the loss of genes encoding lactose permease and &bgr;‐galactosidase in the former. Surprisingly, physiological characterization revealed that neither the type strain of C. tenuis nor this novel species fermented xylose in traditional assays. We reexamined three xylose‐fermenting strains previously identified as C. tenuis and found that these strains belong to the genus Scheffersomyces and are not C. tenuis. We propose Yamadazyma laniorum f.a. sp. nov. to accommodate our new strains and designate its type strain as yHMH7 (=CBS 14780 = NRRL Y‐63967T). Furthermore, we propose the transfer of Candida tenuis to the genus Yamadazyma as Yamadazyma tenuis comb. nov. This approach provides a roadmap for how integrated genome sequence and physiological analysis can yield insight into the mechanisms that generate yeast biodiversity. Graphical Abstract Figure. Here we report the discovery, genome sequence, physiological characterization and taxonomic description of a new species of yeast that is sister to a species previously believed to ferment xylose. Figure. No caption abailable.
Social services

Description Governed primarily by Federal and State mandates, the Department of Social Services (DSS) provides services and programs critical to delivering a countywide system of health, security, and safety for vulnerable County residents. For purposes of this document, the Department’s activities are separated into three budget programs: Administration & Support, Economic Assistance & Employment Services, and Protective Services for Children, Adults & Disabled.
Epalrestat, an Aldose Reductase Inhibitor Prevents Glucose-Induced Toxicity in Human Retinal Pigment Epithelial Cells In Vitro.

PURPOSE Aldose reductase (ALR), the first and rate-limiting enzyme involved in polyol pathway plays a central role in diabetes and its related complications, including diabetic retinopathy (DR). Inhibition of ALR may also be an ideal target for reducing the deleterious effects of DR. Therefore, the purpose of the present study was to investigate the protective effect of epalrestat (EPL), ALR inhibitor on glucose-induced toxicity in ARPE-19 cells. METHODS ARPE-19 cells were challenged with normal glucose (NG, 5 mM) and high glucose (HG1, 25 mM and HG2, 50 mM) in the presence or absence of EPL. ALR and VEGF165 expression in retinal pigment epithelial (RPE) cells under experimental conditions were quantified by real-time polymerase chain reaction using SYBR Green chemistry. Vascular endothelial growth factor (VEGF) secretion in the cell supernatant was measured by Sandwich ELISA. Cytotoxicity of EPL was assessed by MTT assay. ALR inhibitory activity, apoptosis, and sorbitol accumulation were also investigated. RESULTS EPL at studied concentration did not show any toxicity to RPE cells and showed as maximum as 65% ALR inhibition under high glucose condition (HG1). The presence of EPL significantly reduced ALR expression and VEGF levels as induced by high glucose in ARPE-19 cells. CONCLUSION Inhibition of ALR appeared to be beneficial in reducing diabetes-related complications in RPE cells under high glucose condition.
Design of an authentication and key management system for a smart meter gateway in AMI

By applying power usage statistics from smart meters, users are able to save energy in their homes or control smart appliances via home automation systems. However, owing to security and privacy concerns, it is recommended that smart meters (SM) should not have direct communication with smart appliances. In this paper, we propose a design for a smart meter gateway (SMGW) associated with a two-phase authentication mechanism and key management scheme to link a smart grid with smart appliances. With placement of the SMGW, we can reduce the design complexity of SMs as well as enhance the strength of security.