Miracle-dz/UniFAR-FTUs huggingface dataset:
Vanin 1 Gene Role in Modulation of iNOS/MCP-1/TGF-β1 Signaling Pathway in Obese Diabetic Patients

Introduction Cysteamine, a powerful endogenous antioxidant, is produced mostly by the vanin-1 with pantetheinase activity. With regard to glycemic, inflammatory, and redox factors, the current study sought to evaluate the association between the expression of the vanin-1 gene, oxidative stress, and inflammatory and iNOS signaling pathway in obese diabetic patients. Methods We enrolled 67 male subjects with an average age of 53.5 ± 5.0 years, divided into 4 groups according to the WHO guideline. We determined their plasma levels of glucose, insulin, IRI, HbA1c, TC, TG, HDL-C, TNF- α, MCP-1, TGF-β1, SOD, CAT, and TBARs, as well as expression of the iNOS and Vanin1 genes. Results Overweight and obese class I and II diabetics had significantly higher levels of plasma glucose, insulin, HbA1c, TNF-α, MCP-1, TGF-β1, CAT, and TBAR as well as iNOS and vanin-1 gene expression compared to healthy control individuals. In addition, as compared to healthy control individuals, overweight obese class I and II diabetics’ plasma HDL-C levels and blood SOD activity were significantly lower. In addition, ultrasound and computed tomography showed that the presence of a mild obscuring fatty liver with mild hepatic echogenicity appeared in overweight, class I and II obese diabetic patients. Conclusion These findings provide important information for understanding the correlation between Vanin 1 and glycemic, inflammatory, and redox factors in obese patients. Furthermore, US and CT analysis were performed to visualize the observed images of fatty liver due to obesity.
Localization of sound sources by means of unidirectional microphones

This paper describes the results of a new approach devoted to the localization of ground borne acoustic sources. It is demonstrated that an array made of at least three unidirectional microphones can be exploited to identify the position of the source. Sound features extracted either in the time domain or in the frequency domain are used to localize the direction of the incoming sound. This information is then fed into a semi-analytical algorithm aimed at identifying the source location. The novelty of the method presented here consists in the use of unidirectional microphones rather than omnidirectional microphones and in the ability to extract the sound direction by considering features like sound amplitude rather than the time of arrival. Experimental tests have been undertaken in a closed environment and have demonstrated the feasibility of the proposed approach. It is believed that this method may pave the road toward a new generation of reduced-size sound detectors and localizers, and future work is described in the conclusions.
Comparison of high power sputtered dielectric mirrors for PW laser

Latest advances of high intensity laser facilities enable the beam transport of petawatt laser pulses and can provide novel fundamental insights in high energy plasma physics or laser fusion. The very high peak intensities put enormous demands on the required large sized optics. Beam transport mirrors reflect pulses with only several tens of fs and maintain their phase while providing best possible laser induced damage threshold. State of the art, such mirrors are mostly manufactured by thermal evaporation techniques as they provide a large and uniform deposition area. Their porous layer structure causes changing spectral characteristics and wavefront when vacuum-air cycled. Especially large sized mirrors can show crazing and thereby decrease up-time of PW beamlines. In contrast, sputtered layers are very compact and provide non changing characteristics. Stable and reproducible sputter processes enable the deposition of more complex design structures necessary for further optimization of the laser induced damage threshold. However, deposition rate is slow and an uniform large sized area difficult to achieve for sputtered coatings. In our study, we show a self-constructed and built-up ion beam sputtering (IBS) machine capable to deposit large sized substrates up to a diameter of 550 mm. A design study is presented to evaluate best HR810nm mirror to meet demanding spectral requirements and providing maximized laser damage threshold for HAPLS at ELI beamlines. In the end, a field optimized design is applied with a measured LIDT of 0.9 J/cm2 at 42 fs and 1 kHz. This design is used to manufacture beam transport mirrors for HAPLS applying IBS.
Case Study-Based Marketing Modules on Segmenting, Targeting, and Positioning Strategy Materials for Class X in Vocational High Schools

AbstractThis development research aims to develop teaching materials for marketing modules based on case studies of BDP class X segmenting, targeting, and positioning strategies. In addition, this study aims to determine the feasibility of the modules based on expert validator assessments, determine the level of practicality, student responses and module effectiveness. which was developed after the trial phase. Thiagarajan's 4-D development model (Define-Design-Develop-Disseminate) was used in the development of this module. This research was tested on 20 students of the BDP skill program class X marketing subjects for segmenting, targeting, and positioning strategies. The results of the development research show that the learning outcomes of experimental class students who use case study-based marketing modules on segmenting, targeting, and positioning strategies are higher than those of the control class.Keywords: Development, Module, and Case Study Method. AbstrakPenelitian pengembangan ini bertujuan untuk mengembangkan bahan ajar modul pemasaran berdasarkan studi kasus strategi segmentasi, targeting, dan positioning BDP kelas X. Selain itu, penelitian ini bertujuan untuk mengetahui kelayakan modul berdasarkan penilaian validator ahli, mengetahui tingkat kepraktisan, respon siswa dan keefektifan modul. yang dikembangkan setelah tahap uji coba. Model pengembangan 4-D Thiagarajan (Define-Design-Develop-Disseminate) digunakan dalam pengembangan modul ini. Penelitian ini diujicobakan pada 20 siswa program keahlian BDP kelas X mata pelajaran pemasaran untuk strategi segmentasi, targeting, dan positioning. Hasil penelitian pengembangan menunjukkan bahwa hasil belajar siswa kelas eksperimen yang menggunakan modul pemasaran berbasis studi kasus pada strategi segmentasi, targeting, dan positioning lebih tinggi dibandingkan dengan kelas kontrol.Kata kunci: Pengembangan, Modul, dan Metode Studi Kasus.
Quantitative phase imaging of human red blood cells using phase-shifting white light interference microscopy with colour fringe analysis

We report quantitative phase imaging of human red blood cells (RBCs) using phase-shifting interference microscopy. Five phase-shifted white light interferograms are recorded using colour charge coupled device camera. White light interferograms were decomposed into red, green, and blue colour components. The phase-shifted interferograms of each colour were then processed by phase-shifting analysis and phase maps for red, green, and blue colours were reconstructed. Wavelength dependent refractive index profiles of RBCs were computed from the single set of white light interferogram. The present technique has great potential for non-invasive determination of refractive index variation and morphological features of cells and tissues.
Oligomer Formation by Amyloid-β42 in a Membrane-Mimicking Environment in Alzheimer’s Disease

The brains of Alzheimer’s disease (AD) patients contain numerous amyloid plaques that are diagnostic of the disease. The plaques are primarily composed of the amyloidogenic peptides proteins Aβ40 and Aβ42, which are derived by the processing of the amyloid pre-cursor protein (APP) by two proteases called β-secretase and γ-secretase. Aβ42 differs from Aβ40 in having two additional hydrophobic amino acids, ILE and ALA, at the C-terminus. A small percentage of AD is autosomal dominant (ADAD) and linked either to the genes for the presenilins, which are part of γ-secretase, or APP. Because ADAD shares most pathogenic features with widespread late-onset AD, Aβ peptides have become the focus of AD research. Fibrils formed by the aggregation of these peptides are the major component of plaques and were initially targeted in AD therapy. However, the fact that the abundance of plaques does not correlate well with cognitive decline in AD patients has led investigators to examine smaller Aβ aggregates called oligomers. The low levels and heterogeneity of Aβ oligomers have made the determination of their structures difficult, but recent structure determinations of oligomers either formed or initiated in detergents have been achieved. We report here on the structures of these oligomers and suggest how they may be involved in AD.
Consumer Perceived Service Quality and Purchase Intention: Two Moderated Mediation Models Investigation

This study aims to investigate the relationships of perceived service quality, brand image, customer satisfaction, and purchase intention. The moderated mediating role of brand love is examined on 522 mobile phone consumers in Taiwan. This study found a positive relationship between perceived service quality and purchase intention. Brand image and customer satisfaction play a fully mediated role between perceived service quality and purchase intention. Moderated mediation model one and two found that brand love plays a moderated mediating role on perceived service quality through brand image and customer satisfaction to purchase intention respectively. The results indicate that when the degree of brand love is high, the indirect effect of brand image on the perceived service quality of the purchase intention is strong; on the contrary, when the degree of brand love is low, the indirect effect of brand love on the perceived service quality and purchase intention is weak.
Transcriptomic analyses provide new insights into green and purple color pigmentation in Rheum tanguticum medicinal plants

Background Rheum tanguticum Maxim. ex Balf is a traditional Chinese medicinal plant that is commonly used to treat many ailments. It belongs to the Polygonacae family and grows in northwest and southwest China. At high elevations, the color of the plant’s young leaves is purple, which gradually changes to green during the growth cycle. Anthraquinone, which is known for various biological activities, is the main bioactive compound in R. tanguticum. Although a significant amount of research has been done on R. tanguticum in the past, the lack of transcriptome data limits our knowledge of the gene regulatory networks involved in pigmentation and in the metabolism of bioactive compounds in Rheum species. Methods To fill this knowledge gap, we generated high-quality RNA-seq data and performed multi-tissue transcriptomic analyses of R. tanguticum. Results We found that three chlorophyll degradation enzymes (RtPPH, RtPao and RtRCCR) were highly expressed in purple samples, which suggests that the purple pigmentation is mainly due to the effects of chlorophyll degradation. Overall, these data may aid in drafting the transcriptional network in the regulation and biosynthesis of medicinally active compounds in the future.
Privileged Scaffold Decoration for the Identification of the First Trisubstituted Triazine with Anti-SARS-CoV-2 Activity

Current therapy against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) are based on the use of Remdesivir 1, Molnupiravir 2, and the recently identified Nirmatrelvir 3. Unfortunately, these three drugs showed some limitations regarding potency and possible drug–drug interactions. A series of derivatives coming from a decoration approach of the privileged scaffold s-triazines were synthesized and evaluated against SAR-CoV-2. One derivative emerged as the hit of the series for its micromolar antiviral activity and low cytotoxicity. Mode of action and pharmacokinetic in vitro preliminary studies further confirm the role as candidates for a future optimization campaign of the most active derivative identified with this work.
Hyperproduction: a social theory of deep generative models

ABSTRACT Platformized cultural production is in flux. Artificial intelligence is often seen as a key driving force of this shift. This article examines the proliferation of AI-generated media to introduce a new concept to theorize cultural production: hyperproduction. This notion designates the penetration of cultural life with deep generative models. Juxtaposing two empirical use cases–autonomous vehicles and virtual influencers—the article problematises the convergence of simulation and reality through the lens of video game engines. Although those case studies seem to be at odds with each other, they illustrate the mechanisms of new profit models built on rent extraction. Consequently, far from ushering a Matrix-style simulation that cannot be theorized, hyperproduction remains not only grounded in, but also bounded by, reality: the reality of rentier capitalism.
Investigation into a confined laminar swirling jet and entropy production

A confined laminar swirling jet is an interesting research topic due to flow and temperature fields generated in and across the jet. In the present study, a confined laminar swirling jet is studied, and flow and temperature fields are simulated numerically using a control volume approach. In order to investigate the influence of the jet exiting (exiting the nozzle and inleting to the control volume) velocity profiles on the flow and heat transfer characteristics, eight different velocity profiles are considered. To identify each velocity profile, a velocity profile number is introduced. Entropy analysis is carried out to determine the total entropy generation due to heat transfer and fluid friction. Merit number is computed for various swirling velocities and velocity profiles. It is found that swirling motion expands the jet in the radial direction and reduces the jet length in the axial direction. This, in turn, reduces the entropy generation rate and improves the Merit number. Increasing velocity profile number enhances the entropy production rate, but improves the Merit number.
Modulation of limbic resting-state networks by subthalamic nucleus deep brain stimulation

Abstract Beyond the established effects of subthalamic nucleus deep brain stimulation (STN-DBS) in reducing motor symptoms in Parkinson’s disease, recent evidence has highlighted the effect on non-motor symptoms. However, the impact of STN-DBS on disseminated networks remains unclear. This study aimed to perform a quantitative evaluation of network-specific modulation induced by STN-DBS using Leading Eigenvector Dynamics Analysis (LEiDA). We calculated the occupancy of resting-state networks (RSNs) in functional MRI data from 10 patients with Parkinson’s disease implanted with STN-DBS and statistically compared between ON and OFF conditions. STN-DBS was found to specifically modulate the occupancy of networks overlapping with limbic RSNs. STN-DBS significantly increased the occupancy of an orbitofrontal limbic subsystem with respect to both DBS OFF (p = 0.0057) and 49 age-matched healthy controls (p = 0.0033). Occupancy of a diffuse limbic RSN was increased with STN-DBS OFF when compared with healthy controls (p = 0.021), but not when STN-DBS was ON, which indicates rebalancing of this network. These results highlight the modulatory effect of STN-DBS on components of the limbic system, particularly within the orbitofrontal cortex, a structure associated with reward processing. These results reinforce the value of quantitative biomarkers of RSN activity in evaluating the disseminated impact of brain stimulation techniques and the personalization of therapeutic strategies.
Statistical Inference for Generalized Yule Coefficients in 2 × 2 Contingency Tables

The odds ratio is one of the most widely used measures of association for 2 × 2 tables. A generalized Yule coefficient transforms the odds ratio into a correlation-like scale with a range from -1 to 1. Yule’s Y, Yule’s Q, Digby’s H, and a new coefficient are special cases of a generalized Yule coefficient. The new coefficient is shown to be similar in value to the phi coefficient. A confidence interval and sample size formula for a generalized Yule coefficient are proposed. The proposed confidence interval is shown to perform much better than the Wald intervals that are implemented in statistical packages.
Combining qualitative and quantitative methods in studying education

In the humanities, in the last two decades, there has been an evident increase of research combining quantitative and qualitative methods, techniques, approaches, concepts or language. This paper discusses the arguments for and against these research drafts, which most often appear in literature under the title mixed methods research. While some authors consider this type of research as the announcement of the third paradigm in studying social phenomena and the approach that shifts the war between the two paradigms into the past, other authors claim that the paradigms underlying the two basic research orientations are incompatible because they study essentially different phenomena, and therefore the methods from two research traditions cannot be combined in any way. The third viewpoint, which we advocate as well, argues that qualitative and quantitative methods cannot be applied together in one draft for the purposes of triangulation or cross-validation, but that they can be combined for complementary objectives. This paper describes the example of mixed methods draft of complementary objectives in pedagogy, which refers to evaluation of mathematics curriculum. The example shows that combining qualitative and quantitative methods is not only possible, but that it creates the conditions for arriving at data which would not be possible to obtain using only one or the other approach.
A case study analysing the process of analogy‐based learning in a teaching unit about simple electric circuits

The purpose of this case study is to analyse the learning processes of a 16‐year‐old student as she learns about simple electric circuits in response to an analogy‐based teaching sequence. Analogical thinking processes are modelled by a sequence of four steps according to Gentner's structure mapping theory (activate base domain, postulate local matches, connect them to a global match, draw candidate inferences). We consider whether Gentner's theory can be used to account for the details of this specific teaching/learning context. The case study involved video‐taping teaching and learning activities in a 10th‐grade high school course in Germany. Teaching used water flow through pipes as an analogy for electrical circuits. Using Gentner's theory, relational nets were created from the student's statements at different stages of her learning. Overall, these nets reflect the four steps outlined earlier. We also consider to what extent the learning processes revealed by this case study are different from previous analyses of contexts in which no analogical knowledge is available.
Refractive interstellar scintillation in 1741-038

A year of VLA observations of the radio source 1741-038 show that it exhibits pronounced variability at 1.49, 15, and 22 GHz, and somewhat reduced activity at 4.9 GHz. We interpret the unusually strong 1.49 GHz variability as due to refractive interstellar scintillation, and the high-frequency variability as being intrinsic to the source. Most of the scintillation is caused by a single thin screen within a few hundred parsecs of the sun, probably located in the North Polar Spur. 1741-038 offers a unique opportunity to test the refractive scintillation hypothesis through VLBI observations. 35 references.
TTLL11 gene is associated with sustained attention performance and brain networks: A genome‐wide association study of a healthy Chinese sample

Genetic studies on attention have mainly focused on children with attention‐deficit/hyperactivity disorder (ADHD), so little systematic research has been conducted on genetic correlates of attention performance and their potential brain mechanisms among healthy individuals. The current study included a genome‐wide association study (GWAS, N = 1145 healthy young adults) aimed to identify genes associated with sustained attention and an imaging genetics study (an independent sample of 483 healthy young adults) to examine any identified genes' influences on brain function. The GWAS found that TTLL11 showed genome‐wide significant associations with sustained attention, with rs13298112 as the most significant SNP and the GG homozygotes showing more impulsive but also more focused responses than the A allele carriers. A retrospective examination of previously published ADHD GWAS results confirmed an un‐reported, small but statistically significant effect of TTLL11 on ADHD. The imaging genetics study replicated this association and showed that the TTLL11 gene was associated with resting state activity and connectivity of the somatomoter network, and can be predicted by dorsal attention network connectivity. Specifically, the GG homozygotes showed lower brain activity, weaker brain network connectivity, and non‐significant brain‐attention association compared to the A allele carriers. Expression database showed that expression of this gene is enriched in the brain and that the G allele is associated with lower expression level than the A allele. These results suggest that TTLL11 may play a major role in healthy individuals' attention performance and may also contribute to the etiology of ADHD.
Calculating the electrostatic potential of molecules in solution: Method and error assessment

We present a numerical method for calculating the electrostatic potential of molecules in solution, using the linearized Poisson‐Boltzmann equation. The emphasis in this work is on applications to biological macromolecules. The accuracy of the method is assessed by comparisons with analytic solutions for the case of a single charge in a dielectric sphere (Tanford‐Kirkwood theory), which serves as a model for a macromolecule. We find that the solutions are generally accurate to within 5%. Larger errors occur close to the charge and the dielectric boundary, but the maximum error found at ion‐bonding distance (3 Å) from a charge close to the boundary (1 Å deep) is only ∼15%. Several algorithmic improvements, described here, contribute to the accuracy of the method. The programs involved compose a coherent software package, called Del Phi, which goes from a Brookhaven Protein Data Bank format file to calculated electrostatic fields.