Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessment of the Quality of Directly Observed Treatment Short-Course of Tuberculosis in Bahir Dar City Administration, North West Ethiopia

The impacts of tuberculosis is not reduced globally, even though WHO recommends on the growing adherence, the use of DOTS and other interventions in many countries. Providing quality of care for tuberculosis patients is crucial in prevention and control of the disease. The aim of this study is to assess the quality of directly observed Treatment Short Course (DOTS) of Tuberculosis at Government health institutions in Bahir Dar city. Institution based cross-sectional study was conducted from June 30 to August 30/2013 in seven public health institutions in Bahir Dar City Administration. Multistage sampling technique was employed to select health institutions and patients; primary data were collected by interviewing Tuberculosis cases and reviewing their records. The data were coded and entered into Epi Info 3.5. 1 and exported in to SPSS version 16 for analysis, and findings at 95%CI and p value of less than 0.05 were reported as statistically significant. Result: The results of this study showed that Input, process and output quality parameters were 50.2%, 40.2%, and 53.8% respectively, with the overall quality of 47.8%. Variables such as location of health institution, patient privacy, and marital status of patients were significantly associate with quality of DOTS. [AOR=2.14, (95%CI, 1.10-4.15)], [AOR=3.57(95% CI 1.80-7.07)], ([AOR =0.24 (95% CI 0.08-0.77)] respectively. Conclusion and recommendation: Input, process and output qualities of a program were poor in relative to the 100% WHO requirement and these would have inevitably decreased the total quality of DOTS. Success of tuberculosis therapy could be ensured through strict adherence to all the elements of DOTS strategy Thus, Bahir Dar City Administrative health office should train laboratory Professionals on AFB, construct waiting room, and to have regular supervision which may improve those problems seen at each level.
THE EFFECTS OF COUPLE STRESSES IN THE SQUEEZE FILM CHARACTERISTICS BETWEEN A CYLINDER AND A PLANE SURFACE

On the basis of the Stokes micro-continuum theory, the effects of couple stresses resulting from the lubricant blended with various additives upon the squeeze film behavior between a long cylinder and a plane surface are analyzed. Compared to the conventional Newtonianlubricant case, the couple stress effects characterized by the couple stress parameter signify an improvement in the squeeze film characteristics. Increasing values of the couple stress parameter increases the hydrodynamic load-carrying capacity and provides a longer time to prevent cylinder-plane surface contact. The approaching time of the cylinder in reducing the film thickness h m = 1 to h m = 0.01 for the couple stress fluid lubricant is about 27.67, which is longer than the approaching time 22.62 for the case of a Newtonian lubricant.
Cell Cycle-Related Kinase (CCRK) regulates ciliogenesis and Hedgehog signaling in mice

The Hedgehog (Hh) signaling pathway plays a key role in cell fate specification, proliferation, and survival during mammalian development. Cells require a small organelle, the primary cilium, to respond properly to Hh signals and the key regulators of Hh signal transduction exhibit dynamic localization to this organelle when the pathway is activated. Here, we investigate the role of Cell Cycle Related kinase (CCRK) in regulation of cilium-dependent Hh signaling in the mouse. Mice mutant for Ccrk exhibit a variety of developmental defects indicative of inappropriate regulation of this pathway. Cell biological, biochemical and genetic analyses indicate that CCRK is required to control the Hedgehog pathway at the level or downstream of Smoothened and upstream of the Gli transcription factors, Gli2 and Gli3. In vitro experiments indicate that Ccrk mutant cells show a greater deficit in response to signaling over long time periods than over short ones. Similar to Chlamydomonas mutants lacking the CCRK homolog, LF2, mouse Ccrk mutant cells show defective regulation of ciliary length and morphology. Ccrk mutant cells exhibit defects in intraflagellar transport (the transport mechanism used to assemble cilia), as well as slowed kinetics of ciliary enrichment of key Hh pathway regulators. Collectively, the data suggest that CCRK positively regulates the kinetics by which ciliary proteins such as Smoothened and Gli2 are imported into the cilium, and that the efficiency of ciliary recruitment allows for potent responses to Hedgehog signaling over long time periods.
MINERAL CHARACTERIZATION FOR COMBUSTION The Contribution from the Geological Sciences

The material referred to as “mineral matter” in coal has been to the combustion engineer a close to random association of chemical elements. These “random” elements are transformed in the combustion process to ash, react to form boiler deposits (slagging); abrade the internal parts of the boiler (erosion), and produce vapor phases that react with the metals in the boiler to cause metal loss (corrosion). Mineral matter in coal, however, is a far from random occurrence. The elements present in coal occur in predictable assemblages related to the processes that formed the coal. Knowledge of the way in which a coal formed, and of its post-depositional history, provides a guide to the forms and types of “mineral matter” that can be expected. This paper aims to develop such a theme, and to introduce the mineralogical tools that will allow the operator of combustion systems to characterize the non-organic component of coal, for it is this component that is the source of many problems in the combustion process. The knowledge base and techniques of the geological sciences have much to offer the combustion engineer in this particular field. Mineral characterization, often aided by the use of thermodynamic data to draw inferences as to the physical and chemical environment of formation, is the standard approach in the geological sciences. This applies not only to the relatively low-temperature processes that form the minerals actually found in coal, but also to the high-temperature processes associated with the formation and crystallization of magmas, which are similar in many ways to the behaviour of minerals in the combustion environment. When added to the generation of engineering indices,
Inter-comparison of stratospheric mean-meridional circulation and eddy mixing among six reanalysis data sets

Abstract. The stratospheric mean-meridional circulation (MMC) and eddy mixing are compared among six meteorological reanalysis data sets: NCEP-NCAR, NCEP-CFSR, ERA-40, ERA-Interim, JRA-25, and JRA-55 for the period 1979–2012. The reanalysis data sets produced using advanced systems (i.e., NCEP-CFSR, ERA-Interim, and JRA-55) generally reveal a weaker MMC in the Northern Hemisphere (NH) compared with those produced using older systems (i.e., NCEP/NCAR, ERA-40, and JRA-25). The mean mixing strength differs largely among the data products. In the NH lower stratosphere, the contribution of planetary-scale mixing is larger in the new data sets than in the old data sets, whereas that of small-scale mixing is weaker in the new data sets. Conventional data assimilation techniques introduce analysis increments without maintaining physical balance, which may have caused an overly strong MMC and spurious small-scale eddies in the old data sets. At the NH mid-latitudes, only ERA-Interim reveals a weakening MMC trend in the deep branch of the Brewer–Dobson circulation (BDC). The relative importance of the eddy mixing compared with the mean-meridional transport in the subtropical lower stratosphere shows increasing trends in ERA-Interim and JRA-55; this together with the weakened MMC in the deep branch may imply an increasing age-of-air (AoA) in the NH middle stratosphere in ERA-Interim. Overall, discrepancies between the different variables and trends therein as derived from the different reanalyses are still relatively large, suggesting that more investments in these products are needed in order to obtain a consolidated picture of observed changes in the BDC and the mechanisms that drive them.
Increasing T‐type calcium channel activity by β‐adrenergic stimulation contributes to β‐adrenergic regulation of heart rates

Cav3.1 T‐type Ca2+ channel current (ICa‐T) contributes to heart rate genesis but is not known to contribute to heart rate regulation by the sympathetic/β‐adrenergic system (SAS). We show that the loss of Cav3.1 makes the beating rates of the heart in vivo and perfused hearts ex vivo, as well as sinoatrial node cells, less sensitive to β‐adrenergic stimulation; it also renders less conduction acceleration through the atrioventricular node by β‐adrenergic stimulation. Increasing Cav3.1 in cardiomyocytes has the opposite effects. ICa‐T in sinoatrial nodal cells can be upregulated by β‐adrenergic stimulation. The results of the present study add a new contribution to heart rate regulation by the SAS system and provide potential new mechanisms for the dysregulation of heart rate and conduction by the SAS in the heart. T‐type Ca2+ channel can be a target for heart disease treatments that aim to slow down the heart rate
The vestibular implant: frequency-dependency of the electrically evoked vestibulo-ocular reflex in humans

The vestibulo-ocular reflex (VOR) shows frequency-dependent behavior. This study investigated whether the characteristics of the electrically evoked VOR (eVOR) elicited by a vestibular implant, showed the same frequency-dependency. Twelve vestibular electrodes implanted in seven patients with bilateral vestibular hypofunction (BVH) were tested. Stimuli consisted of amplitude-modulated electrical stimulation with a sinusoidal profile at frequencies of 0.5, 1, and 2 Hz. The main characteristics of the eVOR were evaluated and compared to the “natural” VOR characteristics measured in a group of age-matched healthy volunteers who were subjected to horizontal whole body rotations with equivalent sinusoidal velocity profiles at the same frequencies. A strong and significant effect of frequency was observed in the total peak eye velocity of the eVOR. This effect was similar to that observed in the “natural” VOR. Other characteristics of the (e)VOR (angle, habituation-index, and asymmetry) showed no significant frequency-dependent effect. In conclusion, this study demonstrates that, at least at the specific (limited) frequency range tested, responses elicited by a vestibular implant closely mimic the frequency-dependency of the “normal” vestibular system.
Recombinant Adenoviruses Displaying Matrix 2 Ectodomain Epitopes on Their Fiber Proteins as Universal Influenza Vaccines

ABSTRACT Influenza is a zoonotic disease that poses severe threats to public health and the global economy. Reemerging influenza pandemics highlight the demand for universal influenza vaccines. We developed a novel virus platform using extracellular domain IV of the matrix 2 protein (M2e), AdC68-F3M2e, by introducing three conserved M2e epitopes into the HI loop of the chimpanzee adenovirus (AdV) fiber protein. The M2e epitopes were expressed sufficiently on the AdV virion surface without affecting fiber trimerization. Additionally, one recombinant adenovirus, AdC68-F3M2e(H1-H5-H7), induced robust M2e-specific antibody responses in BALB/c mice after two sequential vaccinations and conferred efficient protection against homologous and heterologous influenza virus (IV) challenges. We found that the use of AdV with tandem M2e epitopes in fiber is a potential strategy for influenza prevention. IMPORTANCE Influenza epidemics and pandemics severely threaten public health. Universal influenza vaccines have increasingly attracted interest in recent years. Here, we describe a new strategy that incorporates triple M2e epitopes into the fiber protein of chimpanzee adenovirus 68. We optimized the process of inserting foreign genes into the AdC68 structural protein by one-step isothermal assembly and demonstrated that this 225-bp HI loop insertion could be well tolerated. Furthermore, two doses of adjuvant-free fiber-modified AdC68 could confer sufficient protection against homologous and heterologous influenza virus infections in mice. Our results show that AdC68-F3M2e could be pursued as a novel universal influenza vaccine.
Development of a Bedside Shift Report Policy and Guidelines to Assist Nurses with Patient Care

In 2013, the Hospital Consumer Assessment of Healthcare Providers System (HCAHPS), a national, independent metric of patient satisfaction, revealed room for improvement at a teaching hospital in the southeastern section of the United States. This project reports the development and validation of a Bedside Shift Report (BSR) policy, practice guidelines, and associated documentation. Several initiatives, models, and theories informed thinking about this project. The work of Kurt Lewin and the Institute for Healthcare ImprovementRobert Wood Johnson Foundation’s joint initiative, Transforming Care at the Bedside, both guided the project in terms of the process of institutional change. SBAR (Situation Background Assessment and Recommendation Technique) was the primary model upon which communication strategies were developed. PDSA (Plan-Do-Study-Act) served as a continuous quality improvement model to inform development of the implementation and evaluation plans. Using these concepts, models, and theories, a project team led by the DNP student reviewed relevant literature and considered institutional contexts and goals in order to develop a new institutional bedside-report (BSR) policy along with practice guidelines to inform operationalization of the BSR policy. Five scholars reviewed these products with expertise in relevant content areas in order to validate essential content; both policy and practice guidelines were revised in accordance with feedback. All related documentation needed to implement the products, along with both an implementation and an evaluation plan, were also developed by the project team. Improved nurse-patient communication holds significant potential to improve patient satisfaction and to promote positive social change across the institutional service population. Abstract Development of a Bedside Shift Report Policy and Guidelines to Assist Nurses with Patient Care by Cynthia Ann SnedecorDevelopment of a Bedside Shift Report Policy and Guidelines to Assist Nurses with Patient Care by Cynthia Ann Snedecor MSN, Walden University, 2012 BSN, University of Alabama, 2008 Project Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Nursing Practice Walden University April 2016 Development of a Bedside Shift Report Policy and Guidelines to Assist Nurses with Patient Care by Cynthia Ann Snedecor MSN, Walden University, 2012 BSN, University of Alabama, 2008 Project in Partial Fulfillment of the Requirements for the Degree of Doctor of Nursing Practice Walden University April 2016
Expansion and activation of CD4+CD25+ regulatory T cells in Heligmosomoides polygyrus infection

Regulatory T cell responses to infectious organisms influence not only immunity and immunopathology, but also responses to bystander antigens. Mice infected with the gastrointestinal nematode parasite Heligmosomoides polygyrus show an early Th2‐dominated immune response (days 7–14), but by day 28 a strongly regulatory profile is evident with antigen‐specific IL‐10 release and elevated frequency of CD4+ T cells bearing surface TGF‐β. CD4+CD25+ T cells from infected mice show enhanced capacity to block in vitro effector T cell proliferation. CD4+CD25+ cell numbers expand dramatically during infection, with parallel growth of both CD25+Foxp3+ and CD25+Foxp3– subsets. CTLA‐4 and glucocorticoid‐induced tolerance‐associated receptor, also associated with regulatory T cell function, become more prominent, due to both expanded CD25+ cell numbers and increased expression among the CD25– population. Both intensity and frequency of CD103 expression by CD4+ T cells rise significantly, with greatest expansion among CD25+Foxp3+ cells. While TGF‐β expression is observed among both CD25+Foxp3+ and CD25+Foxp3– subsets, it is the latter population which shows higher TGF‐β staining following infection. These data demonstrate in a chronic helminth infection that Foxp3+ regulatory T cells are stimulated, increasing CD103 expression in particular, but that significant changes occur to other populations including expansion of CD25+TGF‐β+Foxp3– cells, and induction of CTLA‐4 on CD25– non‐regulatory lymphocytes.
EleSense: Elevator-assisted wireless sensor data collection for high-rise structure monitoring

Wireless sensor networks have been widely suggested to be used in Cyber-Physical Systems for Structural Health Monitoring. However, for nowadays high-rise structures (e.g., the Guangzhou New TV Tower, peaking at 600m above ground), the extensive vertical dimension creates enormous challenges toward sensor data collection, beyond those addressed in state-of-the-art mote-like systems. One example is the data transmission from the sensor nodes to the base station. Given the long span of the civil structures, neither a strategy of long-range one-hop data transmission nor short-range hop-by-hop communication is cost-efficient. In this paper, we propose EleSense, a novel high-rise structure monitoring framework that uses elevators to assist data collection. In EleSense, an elevator is attached with the base station and collects data when it moves to serve passengers; as such, the communication distance can be effectively reduced. To maximize the benefit, we formulate the problem as a cross-layer optimization problem and propose a centralized algorithm to solve it optimally. We further propose a distributed implementation to accommodate the hardware capability of sensor nodes and address other practical issues. Through extensive simulations, we show that EleSense has achieved a significant throughput gain over the case without elevators and a straightforward 802.11 MAC scheme without the cross-layer optimization. Moreover, EleSense can greatly reduce the communication costs while maintaining good fairness and reliability. We also conduct a case study with real experiments and data sets on the Guangzhou New TV Tower, which further validates the effectiveness of our EleSense.
p1-FP: Extraction, Classification, and Prediction of Website Fingerprints with Deep Learning

Abstract Recent advances in Deep Neural Network (DNN) architectures have received a great deal of attention due to their ability to outperform state-of-the-art machine learning techniques across a wide range of application, as well as automating the feature engineering process. In this paper, we broadly study the applicability of deep learning to website fingerprinting. First, we show that unsupervised DNNs can generate lowdimensional informative features that improve the performance of state-of-the-art website fingerprinting attacks. Second, when used as classifiers, we show that they can exceed performance of existing attacks across a range of application scenarios, including fingerprinting Tor website traces, fingerprinting search engine queries over Tor, defeating fingerprinting defenses, and fingerprinting TLS-encrypted websites. Finally, we investigate which site-level features of a website influence its fingerprintability by DNNs.
Estrus Synchronization and Periconceptual Supplementation Affect the Profitability of a Replacement Heifer Enterprise12

Experiments evaluated estrus synchronization and periconceptual supplementation on pregnancy rate and calf production. Approximately one-half of heifers in 2 pastures (yr 1) or 4 pastures (yr 2) were injected with prostaglandin F2α (PGF; n = 1,182) or not (NPGF; n = 1,208) 5 d after fertile bulls were introduced for 25 d. In yr 2, a total of 1,230 heifers were randomly assigned to 1 of 4 pastures; 2 received a supplement providing 100 g/d of Ca propionate (1.4 kg/d, 20% CP) 2 d before through 19 d after bull exposure and 2 did not in a 25-d breeding season. Pregnancy rate was reduced (P 0.10). Calf birth weight was greater (P 0.10). In this study, injection of PGF in a 25-d breeding season improved synchrony of calving and increased steer calf weaning weight and value; however, supplemental nutrition during the periconceptual period was of limited value.
Understanding Storytelling in the Context of Information Systems

Storytelling has been used for a long time as a powerful communication tool. In the time of digital transformation storytelling is rediscovered on online platforms for e-commerce or crowdfunding projects. Digital storytelling is also increasingly used in the social media context, including online blogs, on Twitter or in the form of online reviews of services and products. Across all these digital settings, storytelling is used in order to transport a complex content more vividly to the audience and to ensure that the audience remembers the content as long as possible. In these digital forms of storytelling, textual description is frequently supplemented by digital elements like video, pictures or hypertexts. Recognizing importance of these developments, in this paper we provide an overview of existing studies on storytelling with a particular focus on information systems settings.
Bilateral phrenic nerve palsy induced by subcutaneous bortezomib in a patient with newly diagnosed multiple myeloma: first case reported

Meritxell L opez, Xavier Mart ınez Lacasa, Josep M. Mart ı, Ana Munta~ nola, Mar Fern andez, Sonia Huertas , S ılvia Saumell, Isabel De Diego, Gabriela Bustamante, Alba Mesa, Marta Canet, Marta Juli a and Ferran Vall-Llovera Department of Hematology, Hospital Universitari M utua Terrassa, Terrassa, Spain; Department of Medicine, Hospital Universitari M utua Terrassa, Terrassa, Spain; Intensive Care Unit, Hospital Universitari M utua Terrassa, Terrassa, Spain; Department of Neurology, Hospital Universitari M utua Terrassa, Terrassa, Spain
Shiftwork-Mediated Disruptions of Circadian Rhythms and Sleep Homeostasis Cause Serious Health Problems

Shiftwork became common during the last few decades with the growing demands of human life. Despite the social inactivity and irregularity in habits, working in continuous irregular shifts causes serious health issues including sleep disorders, psychiatric disorders, cancer, and metabolic disorders. These health problems arise due to the disruption in circadian clock system, which is associated with alterations in genetic expressions. Alteration in clock controlling genes further affects genes linked with disorders including major depression disorder, bipolar disorder, phase delay and phase advance sleep syndromes, breast cancer, and colon cancer. A diverse research work is needed focusing on broad spectrum changes caused by jet lag in brain and neuronal system. This review is an attempt to motivate the researchers to conduct advanced studies in this area to identify the risk factors and mechanisms. Its goal is extended to make the shift workers aware about the risks associated with shiftwork.