Miracle-dz/UniFAR-FTUs huggingface dataset:
Maintenance rituximab following induction chemoimmunotherapy may prolong progression-free survival in mantle cell lymphoma: a pilot study from the Wisconsin Oncology Network.

BACKGROUND There is no standard first line treatment for mantle cell lymphoma. PATIENTS AND METHODS This was a multicenter phase II pilot study of rituximab and modified hyper-fractionated cyclophosphamide, vincristine doxorubicin, dexamethasone (modified R-hyperCVAD) administered every 28 days for four to six cycles followed by rituximab maintenance therapy consisting of four weekly doses every 6 months for 2 years. Unlike traditional hyperCVAD regimens, no methotrexate or cytarabine was administered. RESULTS Of 22 patients, the overall response rate was 77% and the complete response rate was 64%. With a median follow-up time of 37 months in surviving patients, the median PFS was 37 months and the median OS was not reached. The achievement of a molecular remission did not correlate with improved outcome. The major toxicity was expected myelosuppression. Two patients died during induction treatment. There were no major adverse effects during maintenance therapy. CONCLUSION In a multicenter trial, modified R-hyperCVAD was tolerable and effective induction therapy for untreated MCL. Maintenance rituximab appeared to prolong PFS without increasing toxicity.
Suction sampling in alpine habitats : experiences and suggestions GERNOT

Experiences regarding the first use of a cheap, light and comfortable suction sampler for density estimations of spiders, harvestmen, pseudoscorpions and carabid beetles in steep slopes of alpine habitats (Salzburg, Austria) are shared and discussed. Data from suction sampling and pitfall trapping gained under the same measured period are compared. Suggestions for future usage of this method are provided. Suction sampling in steep slope habitats involves two people, is timeconsuming and thus makes the study expensive. Nevertheless, this is probably the most effective method if quantitative data on arachnids from alpine habitats is to be obtained.
DNA Methylation and Expression Patterns of Key Tissue-specific Genes in Adult Stem Cells and Stomach Tissues

CpG-island margins and non-island-CpG sites round the transcription start sites of CpG-island-positive and -negative genes are methylated to various degrees in a tissue-specific manner. These methylation-variable CpG sites were analyzed to delineate a relationship between the methylation and transcription of the tissue-specific genes. The level of tissue-specific transcription was estimated by counting the number of the total transcripts in the SAGE (serial analysis of gene expression) database. The methylation status of 12 CpG-island margins and 21 non-island CpG sites near the key tissue-specific genes was examined in pluripotent stromal cells obtained from fat and bone marrow samples as well as in lineage-committed cells from marrow bulk, stomach, colon, breast, and thyroid samples. Of the 33 CpG sites examined, 10 non-island-CpG sites, but none of the CpG-island margins were undermethylated concurrent with tissue-specific expression of their nearby genes. The net methylation of the 33 CpG sites and the net amount of non-island-CpG gene transcripts were high in stomach tissues and low in stromal cells. The present findings suggest that the methylation of the non-island-CpG sites is inversely associated with the expression of the nearby genes, and the concert effect of transitional-CpG methylation is linearly associated with the stomach-specific genes lacking CpG-islands.
Solving an inverse kinematics problem for a humanoid robot\u2019s imitation of human motions using optimization

Interactions of a humanoid with a human are important, when the humanoid is requested to provide people with human-friendly services in unknown or uncertain environment. Such interactions may require more complicated and human-like behaviors from the humanoid. In this work the arm motion of a human is discussed as the early stage of human motion imitation by a humanoid. A motion capture system is used to obtain human-friendly arm motions as references for the humanoid. However the captured motions may not be applied directly to the humanoid, since the differences in geometric or dynamics aspects as length, degrees of freedom, and kinematics and dynamics capabilities exist between the humanoid and the human. To overcome this difficulty a method to adapt captured motions to a humanoid is developed. The geometric difference in the arm length is resolved by scaling the arm length of the humanoid with a constant based on a length ratio. Using the scaled geometry of the humanoid the imitation of actor’s arm motion is realized by solving an inverse kinematics problem that is formulated as an optimization problem. The errors between the captured trajectories of actor arms and the approximated trajectories of humanoid arms are minimized. Such dynamics capabilities of the joint motors as limits of joint position, velocity and acceleration are also imposed on the optimization problem. Two motions of one hand waving and performing a statement in sign language are imitated by a humanoid in dynamics simulation.
Metabolism of Phosphatidylinositol 4-Kinase IIIα-Dependent PI4P Is Subverted by HCV and Is Targeted by a 4-Anilino Quinazoline with Antiviral Activity

4-anilino quinazolines have been identified as inhibitors of HCV replication. The target of this class of compounds was proposed to be the viral protein NS5A, although unequivocal proof has never been presented. A 4-anilino quinazoline moiety is often found in kinase inhibitors, leading us to formulate the hypothesis that the anti-HCV activity displayed by these compounds might be due to inhibition of a cellular kinase. Type III phosphatidylinositol 4-kinase α (PI4KIIIα) has recently been identified as a host factor for HCV replication. We therefore evaluated AL-9, a compound prototypical of the 4-anilino quinazoline class, on selected phosphatidylinositol kinases. AL-9 inhibited purified PI4KIIIα and, to a lesser extent, PI4KIIIβ. In Huh7.5 cells, PI4KIIIα is responsible for the phosphatidylinositol-4 phosphate (PI4P) pool present in the plasma membrane. Accordingly, we observed a gradual decrease of PI4P in the plasma membrane upon incubation with AL-9, indicating that this agent inhibits PI4KIIIα also in living cells. Conversely, AL-9 did not affect the level of PI4P in the Golgi membrane, suggesting that the PI4KIIIβ isoform was not significantly inhibited under our experimental conditions. Incubation of cells expressing HCV proteins with AL-9 induced abnormally large clusters of NS5A, a phenomenon previously observed upon silencing PI4KIIIα by RNA interference. In light of our findings, we propose that the antiviral effect of 4-anilino quinazoline compounds is mediated by the inhibition of PI4KIIIα and the consequent depletion of PI4P required for the HCV membranous web. In addition, we noted that HCV has a profound effect on cellular PI4P distribution, causing significant enrichment of PI4P in the HCV-membranous web and a concomitant depletion of PI4P in the plasma membrane. This observation implies that HCV – by recruiting PI4KIIIα in the RNA replication complex – hijacks PI4P metabolism, ultimately resulting in a markedly altered subcellular distribution of the PI4KIIIα product.
Curved Noncommutative Tori as Leibniz Quantum Compact Metric Spaces

We prove that curved noncommutative tori, introduced by Dabrowski and Sitarz, are Leibniz quantum compact metric spaces and that they form a continuous family over the group of invertible matrices with entries in the commutant of the quantum tori in the regular representation, when this group is endowed with a natural length function.
CAPG enhances breast cancer metastasis by competing with PRMT5 to modulate STC-1 transcription

Macrophage-capping protein (CAPG) has been shown to promote cancer cell metastasis, although the mechanism remains poorly understood. Methods: Breast cancer (BC) tissue microarray was used to test the role of CAPG in the prognosis of BC patients. Xenograft mice model was used to validate the metastasis promotion role of CAPG in vivo. Gene expression array, chromatin immunoprecipitation and luciferase report assay were performed to search for the target genes of CAPG. Protein immunoprecipitation, MS/MS analysis, tissue microarray and histone methyltransferase assay were used to explore the mechanism of CAPG regulating stanniocalcin 1 (STC-1) transcription. Results: We demonstrate a novel mechanism by which CAPG enhances BC metastasis via promoting the transcription of the pro-metastatic gene STC-1, contributing to increased metastasis in BC. Mechanistically, CAPG competes with the transcriptional repressor arginine methyltransferase 5 (PRMT5) for binding to the STC-1 promoter, leading to reduced histone H4R3 methylation and enhanced STC-1 transcription. Our study also indicates that both CAPG and PRMT5 are independent prognostic factors for BC patient survival. High CAPG level is associated with poor survival, while high PRMT5 expression favors a better prognosis in BC patients. Conclusion: Our findings identify a novel role of CAPG in the promotion of BC metastasis by epigenetically enhancing STC-1 transcription.
Denervation Causes Fiber Atrophy and Myosin Heavy Chain Co-Expression in Senescent Skeletal Muscle

Although denervation has long been implicated in aging muscle, the degree to which it is causes the fiber atrophy seen in aging muscle is unknown. To address this question, we quantified motoneuron soma counts in the lumbar spinal cord using choline acetyl transferase immunhistochemistry and quantified the size of denervated versus innervated muscle fibers in the gastrocnemius muscle using the in situ expression of the denervation-specific sodium channel, Nav1.5, in young adult (YA) and senescent (SEN) rats. To gain insights into the mechanisms driving myofiber atrophy, we also examined the myofiber expression of the two primary ubiquitin ligases necessary for muscle atrophy (MAFbx, MuRF1). MN soma number in lumbar spinal cord declined 27% between YA (638±34 MNs×mm−1) and SEN (469±13 MNs×mm−1). Nav1.5 positive fibers (1548±70 μm2) were 35% smaller than Nav1.5 negative fibers (2367±78 μm2; P<0.05) in SEN muscle, whereas Nav1.5 negative fibers in SEN were only 7% smaller than fibers in YA (2553±33 μm2; P<0.05) where no Nav1.5 labeling was seen, suggesting denervation is the primary cause of aging myofiber atrophy. Nav1.5 positive fibers had higher levels of MAFbx and MuRF1 (P<0.05), consistent with involvement of the proteasome proteolytic pathway in the atrophy of denervated muscle fibers in aging muscle. In summary, our study provides the first quantitative assessment of the contribution of denervation to myofiber atrophy in aging muscle, suggesting it explains the majority of the atrophy we observed. This striking result suggests a renewed focus should be placed on denervation in seeking understanding of the causes of and treatments for aging muscle atrophy.
The impact of US versus Indian BMD reference standards on the diagnosis of osteoporosis among South Asian Indians living in the United States

The relationship between bone mineral density (BMD) and fracture risk is not well-established for non-white populations. There is no established BMD reference standard for South Asians. Dual energy x-ray absorptiometry (DXA) was used to measure BMD at total hip and lumbar spine in 150 US-based South Asian Indians. For each subject T-scores were calculated using BMD reference values based on US white, North Indian and South Indian populations, and the resulting WHO BMD category assignments were compared. Reference standards derived from Indian populations classified a larger proportion of US-based Indians as normal than did US white-based standards. The percentage of individuals reclassified when changing between reference standards varied by skeletal site and reference population origin, ranging from 13% (95% CI, 7–18%), when switching from USwhiteto North Indian-based standard for total hip, to 40% (95% CI, 32–48%), when switching from US white to South Indian reference values for lumbar spine. These finding illustrate that choice of reference standard has a significant effect on the diagnosis of osteoporosis in South Asians, and underscore the importance of future research to quantify the relationship between BMD and fracture risk in this population.
Wing Shape Sensing from Measured Strain

A new two-step theory is investigated for predicting the deflection and slope of an entire structure using measured strain at discrete locations. In the first step, a measured strain is fitted using a piecewise least-squares curve fitting method together with the cubic spline technique. These fitted strains are integrated twice to obtain deflection data along the optical fibers. In the second step, computed deflection along the optical fibers is combined with a finite-element model of the structure in order to interpolate and extrapolate the deflection and slope of the entire structure through the use of the System Equivalent Reduction and Expansion Process. The theory is first validated on a computational model, a cantilevered rectangular plate wing. The theory is then applied to test data from a cantilevered swept-plate wing model. Computed results are compared with finite-element results, results using another strain-based method, and photogrammetry data. In general, excellent matching between the targ.
An analytical model for transient deformation of viscoelastically coated beams: Applications to static-mode microcantilever chemical sensors

The problem governing the transient deformation of an elastic cantilever beam with viscoelastic coating, subjected to a time-dependent coating eigenstrain, is mathematically formulated. An analytical solution for an exponential eigenstrain history, exact within the context of beam theory, is obtained in terms of the coating and base layer thicknesses, the elastic modulus of the base material, the initial coating modulus, the coating relaxation percentage (0%–100%), and the time constants of the coating’s relaxation process and its eigenstrain history. Approximate formulas, valid for thin coatings, are derived as special cases to provide insight into system behavior. Main results include (1) the time histories of the beam curvature and the coating stresses, (2) a criterion governing the response type (monotonic or “overshoot” response), and (3) simple expressions for the overshoot ratio, defined as the peak response scaled by the steady-state response, and the time at which the peak response occurs. Applic.
Active Roof Cooling of Atria

In the built environment there is a clear need to apply more renewable energy source. The biggest source of renewable energy is of course the sun. It is interesting to look at the application of active and passive solar energy and how it could be improved. Recently large glass-covered spaces, like atria or winter gardens, are more applied to make use of passive solar energy. However, the temperatures in the large glass-covered space can rise to such levels that there is no longer an acceptable thermal indoor environment. Therefore additional cooling devices are often necessary when applying glass-covered roofs for spaces. The necessary application of mechanical cooling reduces the benefits of the use of passive solar energy. This study is examining how building integrated evaporative cooling can contribute to temperature reduction in large glass-covered spaces such as atria. By maintaining a thin water film on super hydrophilic TiO2-coated building surfaces it is possible to reduce the surface temperatures due to evaporation of the water. The lower surface temperatures contribute to the reduction of indoor air temperature since the intensity of heat transfer through the cold surface is reduced. Variables which largely affect this evaporation process are the differences in water vapor pressure in the air and at the surface, the size of the contact surface and the specific mass transfer coefficient. In order to predict the thermal improvement effect of sprinkling water on the TiO2- coated external building surfaces. An experiment was performed to measure the effect of super hydrophilic roof cooling. It proved that TiO2- coated building surfaces, with a thin water film results in a significant reduction of the indoor temperatures. Active roof cooling shows a lot of potential for future energy-saving on cooling of buildings.
Environmental enteric dysfunction pathways and child stunting: A systematic review

Background Environmental enteric dysfunction (EED) is commonly defined as an acquired subclinical disorder of the small intestine, characterized by villous atrophy and crypt hyperplasia. EED has been proposed to underlie stunted growth among children in developing countries. A collection of biomarkers, organized into distinct domains, has been used to measure different aspects of EED. Here, we examine whether these hypothesized relationships, among EED domains and between each domain and stunting, are supported by data from recent studies. Methodology A systematic literature search was conducted using PubMed, MEDLINE, EMBASE, Web of Science, and CINAHL between January 1, 2010 and April 20, 2017. Information on study objective, design, population, location, biomarkers, and results were recorded, as well as qualitative and quantitative definitions of EED. Biomarkers were organized into five EED domains, and the number of studies that support or do not support relationships among domains and between each domain with stunting were summarized. Results There was little evidence to support the pathway from intestinal permeability to microbial translocation and from microbial translocation to stunting, but stronger support existed for the link between intestinal inflammation and systemic inflammation and for intestinal inflammation and stunting. There was conflicting evidence for the pathways from intestinal damage to intestinal permeability and intestinal damage to stunting. Conclusions These results suggest that certain EED biomarkers may require reconsideration, particularly those most difficult to measure, such as microbial translocation and intestinal permeability. We discuss several issues with currently used biomarkers and recommend further analysis of pathogen-induced changes to the intestinal microbiota as a pathway leading to stunting.
On temporal difference algorithms for continuous systems

This article proposes a general, intuitive and rigorous framework for designing temporal differences algorithms to solve optimal control problems in continuous time and space. Within this framework, we derive a version of the classical TD(λ) algorithm as well as a new TD algorithm which is similar, but designed to be more accurate and to converge as fast as TD(λ) for the best values of λ without the burden of finding these values.
Continuous Sensor Placement

Existing solutions to the sensor placement problem are based on sensor selection, in which the best subset of available sampling locations is chosen such that a desired estimation accuracy is achieved. However, the achievable estimation accuracy of sensor placement via sensor selection is limited to the initial set of sampling locations, which are typically obtained by gridding the continuous sampling domain. To circumvent this issue, we propose a framework of continuous sensor placement. A continuous variable is augmented to the grid-based model, which allows for off-the-grid sensor placement. The proposed offline design problem can be solved using readily available convex optimization solvers.
Autoregressive moving average graph filters a stable distributed implementation

We present a novel implementation strategy for distributed autoregressive moving average (ARMA) graph filters. Differently from the state of the art implementation, the proposed approach has the following benefits: (i) the designed filter coefficients come with stability guarantees, (ii) the linear convergence time can now be controlled by the filter coefficients, and (iii) the stable filter coefficients that approximate a desired frequency response are optimal in a least squares sense. Numerical results show that the proposed implementation outperforms the state of the art distributed infinite impulse response (IIR) graph filters. Further, even at fixed distributed costs, compared with the popular finite impulse response (FIR) filters, at high orders our method achieves tighter low-pass responses, suggesting that it should be preferable in accuracy-demanding applications.
The Maize (Zea mays L.) AUXIN/INDOLE-3-ACETIC ACID Gene Family: Phylogeny, Synteny, and Unique Root-Type and Tissue-Specific Expression Patterns during Development

The plant hormone auxin plays a key role in the coordination of many aspects of growth and development. AUXIN/INDOLE-3-ACETIC ACID (Aux/IAA) genes encode instable primary auxin responsive regulators of plant development that display a protein structure with four characteristic domains. In the present study, a comprehensive analysis of the 34 members of the maize Aux/IAA gene family was performed. Phylogenetic reconstructions revealed two classes of Aux/IAA proteins that can be distinguished by alterations in their domain III. Seven pairs of paralogous maize Aux/IAA proteins were discovered. Comprehensive root-type and tissue-specific expression profiling revealed unique expression patterns of the diverse members of the gene family. Remarkably, five of seven pairs of paralogous genes displayed highly correlated expression patterns in roots. All but one (ZmIAA23) tested maize Aux/IAA genes were auxin inducible, displaying two types of auxin induction within three hours of treatment. Moreover, 51 of 55 (93%) differential Aux/IAA expression patterns between different root-types followed the expression tendency: crown roots > seminal roots > primary roots > lateral roots. This pattern might imply root-type-specific regulation of Aux/IAA transcript abundance. In summary, the detailed analysis of the maize Aux/IAA gene family provides novel insights in the evolution and developmental regulation and thus the function of these genes in different root-types and tissues.