Miracle-dz/UniFAR-FTUs huggingface dataset:
P-Selectin is a Critical Factor for Platelet-Mediated Protection on Restraint Stress-Induced Gastrointestinal Injury in Mice

Psychological stress is associated with increased risk of gastrointestinal (GI) tract diseases. Evidence indicated that platelets facilitate GI tissue repair in intestinal anastomosis models. However, whether platelets are involved in native mechanism of the rescue of stress-induced GI injury for maintaining the GI homeostasis remains elusive. Because P-selectin-deficient (Selp−/−) mice displayed higher stress-induced GI injury compared to the wild-type (Selp+/+) mice, and P-selectin is specifically expressed in platelets, we hypothesize that P-selectin-expressing platelets play a protective role in the rescue of stress-induced GI injury. Our goal is to clarify the putative protective role of platelets in a GI system, thereby develop a feasible intervention strategy, such as platelet transfer, to overcome stress-induced GI injury. Through monitoring the plasma levels of GI-nonabsorbable Evans blue dye to reveal the progression course of GI injury in live mice, we found that intravenous treatments of purified platelets ameliorated stress-induced GI leakage. The transfer of platelets from wild-type mice was more potent than from Selp−/− mice in the rescue of stress-induced-GI leakage in the recipients. As such, platelet transfer-mediated rescue was conducted in a P-selectin dependent manner. Additionally, platelet-mediated protection is associated with corrections of stress-induced aberrant GI mRNA expressions, including tight junctions claudin 3 and occludin, as well as stress-induced genes activating transcription factor 3 and AMP-activated protein kinase, after the transfer of wild-type platelets into wild-type and Selp−/− mice. Furthermore, the stress-induced apoptosis of CD326+ GI epithelial cells was rescued by the transfer of wild type, but not P-selectin-deficient platelets. These results suggest that platelet plays a protective role for maintaining the GI homeostasis during stress in vivo, and that P-selectin is a molecular target for managing stress-induced GI tract injury.
Mediating Effect of Self-Cognitive Oral Health Status on the Effect of Obstructive Sleep Apnea Risk Factors on Quality of Life (HINT-8) in Middle-Aged Korean Women: The Korea National Health and Nutrition Examination Survey

Background: Obstructive sleep apnea and oral health are highly correlated with quality of life. The purpose of this study is to determine the mediating effect of self-cognitive oral health status on the effect of obstructive sleep apnea (OSA) risk factors on quality of life in middle-aged Korean women using the 2019 National Health and Nutrition Examination Survey data. Methods: A hierarchical regression analysis was performed on the mediating effect of self-cognitive oral health status on the effects of OSA risk factors on health-related quality of life (Korean health-related quality of life instrument with 8 items; HINT-8). Results: Self-cognitive oral health status as a parameter had a significant effect on quality of life (β = 0.713, p < 0.001). Compared to the effect of the OSA risk factor of the second stage on the quality of life (β = −1.329, p < 0.001), the input of the third stage of self-cognitive oral health was partially mediated (β = −1.280, p <0.001). Conclusions: Therefore, if middle-aged women have OSA risk factors, they should try to improve their quality of life by managing oral health as well as OSA treatment.
Multimodality Molecular Imaging of Stem Cells Therapy of Myocardial Infarction

Stem cell therapy in patients with acute myocardial infarction promises a new exciting option. However, the long term fate of stem cells transplanted into myocardial is not clear. Molecular imaging play a vital role in tracking stem cells after intramyocardial delivery as well as in helping us understand the mechanisms of stem cell biology in vivo. In this review, we summarize the principles underlying four kinds of stem cells applied into myocardial infarction and the major tracking methods. Finally, we discuss that molecular imaging will be useful to the successful clinical implementation of this novel therapy.
Floer homology and the symplectic isotopy problem

The symplectic isotopy problem is a question about automorphisms of a compact symplectic manifold. It asks whether the relation of symplectic isotopy between such automorphism is finer than the relation of diffeotopy (smooth isotopy). The principal result of this thesis is that there are symplectic manifolds for which the answer is positive; in fact, a large class of symplectic four-manifolds is shown to have this property. This result is the consequence of the study of a special class of symplectic automorphisms, called generalized Dehn twists. The hard part of studying the symplectic isotopy problem is how to prove that two given symplectic automorphisms are not symplectically isotopic. Symplectic Floer homology theory assigns a ‘homology group’ to any symplectic automorphism. These groups are invariant under symplectic isotopy, hence an obvious candidate for the task. While there is no general procedure for computing the Floer homology groups, it turns out that this is feasible for generalized Dehn twists. The computation involves an extension of the functorial structure of the Floer homology groups: we introduce homomorphisms induced by certain symplectic fibrations with singularities. Then we use the fact that generalized Dehn twists appear as monodromy maps of such fibrations. These induced maps on Floer homology groups may be of interest independently of their contribution to the symplectic isotopy problem. The thesis is divided into three parts: the first part presents the symplectic isotopy problem, introduces generalized Dehn twists, and explains the consequences of the determination of their Floer homology groups. The second part is devoted to Floer homology; its main focus are the new induced maps. The final part describes the computation of the Floer homology groups of a generalized Dehn twist.
Analysis of boundary point (break point) in Linear Delay Model for nanoscale VLSI standard cell library characterization at PVT corners

In VLSI chip design flow, Static Timing Analysis (STA) is used for fast and accurate analysis of data-path delay. This process is fast because delay is picked from Look Up Tables (LUT) rather than conventional SPICE simulations. But accuracy of this method depends upon the underlying delay model with which LUT was characterized. Non Linear Delay Model (NLDM) based LUTs are quite common in industries. These LUT requires huge amount to time during characterization because of huge number of SPICE simulations done at arbitrary points. To improve this people proposed various other delay models like alpha-power and piecewise linear delay models. Bulusu et al proposed Linear Delay Model(LDM) which reduces LUT generation time to 50 percent. LDM divides delay curve w.r. t input rise time(trin) into two different region one is linear and other is non-linear. This boundary point between linear and non- linear region was called break point (trb). Linear region will be done if we simulate at only two points. This advantage will be possible by having knowledge of this break point at various PVT corners. In this paper, We will analyze this break point and will give a formula to find out this at various PVT corners. Knowledge about (trb) will restrict LUT simulations only in non-linear region and will help us in saving huge amount of time during LUT characterization.
Use of Instant Messaging Software in a German Hospital—An Exploratory Investigation among Physicians

Internationally, evidence exists that physicians use instant messaging services for communication tasks in everyday clinical practice However, there are only few data on physicians in Germany in this regard. Therefore, at the initiation of our project “DocTalk-Dialog meets Chatbot: Collaborative Learning and Teaching in the Process of Work”, we conducted a stakeholder survey with an exploratory research approach. The aim was to gain initial insights into use of instant messaging software and attitudes towards data security and advantages and disadvantages before implementing a data-secure in-house messaging platform. N = 70 physicians at Charité-Universitätsmedizin Berlin completed an exploratory questionnaire with closed and open-ended questions. Quantitative data were analyzed using descriptive statistics and qualitative data using thematic analysis. The use of messenger software was not widespread in the sample studied. Physicians most frequently used face-to-face contact for communication. On average, up to ten instant messages were exchanged per day, mainly among colleagues, to answer mutual questions, and to send pictures. With a high awareness of privacy-related restrictions among participating physicians, advantages such as fast and uncomplicated communication were also highlighted. An instant messenger solution that complies with the German data protection guidelines is needed and should be investigated in more detail.
Multicellular 3D Models for the Study of Cardiac Fibrosis

Ex vivo modelling systems for cardiovascular research are becoming increasingly important in reducing lab animal use and boosting personalized medicine approaches. Integrating multiple cell types in complex setups adds a higher level of significance to the models, simulating the intricate intercellular communication of the microenvironment in vivo. Cardiac fibrosis represents a key pathogenetic step in multiple cardiovascular diseases, such as ischemic and diabetic cardiomyopathies. Indeed, allowing inter-cellular interactions between cardiac stromal cells, endothelial cells, cardiomyocytes, and/or immune cells in dedicated systems could make ex vivo models of cardiac fibrosis even more relevant. Moreover, culture systems with 3D architectures further enrich the physiological significance of such in vitro models. In this review, we provide a summary of the multicellular 3D models for the study of cardiac fibrosis described in the literature, such as spontaneous microtissues, bioprinted constructs, engineered tissues, and organs-on-chip, discussing their advantages and limitations. Important discoveries on the physiopathology of cardiac fibrosis, as well as the screening of novel potential therapeutic molecules, have been reported thanks to these systems. Future developments will certainly increase their translational impact for understanding and modulating mechanisms of cardiac fibrosis even further.
What Is in the Salad? Escherichia coli and Antibiotic Resistance in Lettuce Irrigated with Various Water Sources in Ghana

Introduction: Safety of the environment in which vegetables are grown, marketed and consumed is paramount as most are eaten raw. Irrigation sources include open drains and streams, which are often contaminated with human and animal waste due to poor sanitation infrastructure. In irrigated vegetable farms using such sources in Ghana, we assessed Escherichia coli counts, antibiotic resistance patterns and resistant genes on irrigated lettuce. Methods: A cross-sectional study was conducted between January–May 2022, involving five major vegetable farms in Ghana. Results: Escherichia coli was found in all 25 composite lettuce samples analyzed. Counts expressed in CFU/g ranged from 186 to 3000, with the highest counts found in lettuce irrigated from open drains (1670) and tap water using hose pipes (3000). Among all bacterial isolates, resistance ranged between 49% and 70% for the Watch group of antibiotics, 59% for the Reserved group and 82% were multidrug-resistant. Of 125 isolates, 60 (48%) were extended-spectrum beta-lactamase-producing, of which five (8%) had the blaTEM-resistant gene. Conclusions: Lettuce was contaminated with Escherichia coli with high levels of antibiotic resistance. We call on the Ghana Ministry of Food and Agriculture, Food and Drugs Authority and other stakeholders to support farmers to implement measures for improving vegetable safety.
Contraction Band Necrosis with Dephosphorylated Connexin 43 in Rat Myocardium after Daily Cocaine Administration

Contraction band necrosis (CBN) is a common abnormality found in the myocardium of cocaine abusers, but is rarely reported in experimental models of cocaine abuse. Connexin 43 (Cx43) is essential for cardiac intercellular communication and the propagation of CBN. Under stress or injury, cardiac Cx43 is dephosphorylated, which is related to cardiomyocyte dysfunction and pathogenesis, whereas adiponectin exerts beneficial effects in the myocardium. In this study, we explore the effects of cocaine on cardiac Cx43 in vivo. Rats were administered cocaine via the tail vein at 20 mg/kg/day for 14 days, and showed widespread CBN, microfocal myocarditis and myocardial fibrosis, corresponding to a dysfunction of cardiac mitochondria under increased oxidative stress. The increase in dephosphorylated cardiac Cx43 and its negative correlation with the myocardial distribution of CBN after cocaine administration were determined. In addition, apoptosis and necroptosis, as well as increased adiponectin levels, were observed in the myocardium after cocaine exposure. Accordingly, we found altered profiles of cardiac Cx43, CBN and its negative correlation with dephosphorylated cardiac Cx43, and the possible involvement of adiponectin in the myocardium after 14 days of cocaine administration. The latter might play a protective role in the cardiotoxicity of cocaine. The current findings would be beneficial for establishing novel therapeutic strategies in cocaine-induced cardiac consequences.
Recent progress on the study of the charmoniumlike states

In this article, we review the recent experimental studies on the charmoniumlike states, mainly from the e+e- annihilation experiments BESIII, Belle, BaBar, and CLEO-c, and the hadron collider experiment LHCb. We discuss the results on the X(3872), the vector Y states [Y(4008), Y(4660), and those in e+e- → π+π-hc], and the charged charmoniumlike states.
Exploring deep transfer learning interference classification on neural style transfer generated synthetic SAR datasets

Synthetic aperture radar (SAR) imagery has received a great deal of attention in recent years due to the deployment of many cutting edge spaceborne radar systems providing high resolution imagery. However, severe image distortion is a critical problem, and this is often a result of radio frequency interference (RFI) and noise. Issues that arise from distortion include missing detection and inaccurate height maps.SAR images are particularly important for classification and automatic target recognition (ATR) tasks. For such applications, access to comprehensive databases of SAR images as well as SAR images contaminated with RFI and noise is critical to enable the effective training and optimisation of classification algorithms and to provide a common baseline for benchmarking purposes. Given these challenges, the purpose of this paper is to show that neural style transfer can be used to induce RFI and noise into SAR images. We can also further classify the type of contamination using image classification techniques. The experimental data is shown to verify the efficiency of our approach.
Transcriptional and Epigenomic Markers of the Arterial-Venous and Micro/Macro-Vascular Endothelial Heterogeneity within the Umbilical-Placental Bed

Umbilical and placental vessels and endothelial cells (EC) are common models to study placental function and vascular programming. Arterio-venous differences are present in the umbilical endothelium; however, the heterogeneity of small placental vessels and the expression of potential micro- vs. macro-vascular (MMV) markers are poorly described. Here, we performed a meta-analysis of transcriptomic and DNA methylation data from placental and umbilical EC. Expression and methylation profiles were compared using hierarchical clustering, dimensionality reduction (i.e., tSNE, MDS, and PHATE), and enrichment analysis to determine the occurrence of arterio-venous (AVH) and micro-macro heterogeneity (MMH). CpG sites correlated with gene expression of transcriptional markers of MMH and AVH were selected by Lasso regression and used for EC discrimination. General transcriptional profile resulted in clear segregation of EC by their specific origin. MM and AVH grouping were also observed when microvascular markers were applied. Altogether, this meta-analysis provides cogent evidence regarding the transcriptional and epigenomic profiles that differentiate among EC, proposing novel markers to define phenotypes based on MM levels.
Spin pumping and interlayer exchange coupling through palladium

The magnetic behaviour of ultrathin ferromagnetic films deposited on substrates is strongly affected by the properties of the substrate. We investigate the spin pumping rate, interlayer exchange coupling and dynamic exchange coupling between ultrathin ferromagnetic films through palladium, a non-magnetic substrate that displays strong Stoner enhancement. We find that the interlayer exchange coupling, both in the static and dynamic versions, is qualitatively affected by the substrate's Stoner enhancement. For instance, the oscillatory behavior that is a hallmark property of the RKKY exchange coupling is strongly suppressed by Stoner enhancement. Although the spin pumping rate of ferromagnetic films atop palladium is only mildly changed by Stoner enhancement the change is large enough to be detected experimentally. The qualitative aspects of our results for palladium are expected to remain valid for any non-magnetic substrate where Coulomb repulsion is large.
African American Females Are Less Metabolically Flexible Compared with Caucasian American Females following a Single High-Fat Meal: A Pilot Study

The relationship between metabolic flexibility (MF) and components of metabolic disease has not been well-studied among African American (AA) females and may play a role in the higher incidence of chronic disease among them compared with Caucasian American (CA) females. This pilot study aimed to compare the metabolic response of AA and CA females after a high-fat meal. Eleven AA (25.6 (5.6) y, 27.2 (6.0) kg/m2, 27.5 (9.7) % body fat) and twelve CA (26.5 (1.5) y, 25.7 (5.3) kg/m2, 25.0 (7.4) % body fat) women free of cardiovascular and metabolic disease and underwent a high-fat meal challenge (55.9% fat). Lipid oxidation, insulin, glucose, and interleukin (IL)-8 were measured fasted, 2 and 4 h postprandial. AA females had a significantly lower increase in lipid oxidation from baseline to 2 h postprandial (p = 0.022), and trended lower at 4 h postprandial (p = 0.081) compared with CA females, indicating worse MF. No group differences in insulin, glucose or HOMA-IR were detected. IL-8 was significantly higher in AA females compared with CA females at 2 and 4 h postprandial (p = 0.016 and p = 0.015, respectively). These findings provide evidence of metabolic and inflammatory disparities among AA females compared with CA females that could serve as a predictor of chronic disease in individuals with a disproportionately higher risk of development.
THE ROLE OF SiO AS A TRACER OF PAST STAR FORMATION EVENTS: THE CASE OF THE HIGH-MASS PROTOCLUSTER NGC 2264-C

NGC 2264-C is a high-mass protocluster where several star formation events are known to have occurred. To investigate whether past protostellar activity has left a chemical imprint in this region, we mapped it in SiO( ), which is a shock tracer, and several other molecular lines with the Nobeyama 45 m telescope. Our observations show the presence of a complex network of protostellar outflows. The strongest SiO emission lies beyond a radius of ∼0.1 pc with respect to the center of the clump and is characterized by broad ( km s−1) lines and abundances of with respect to H2. Interestingly, SiO appears to be relatively depleted ( ) within this radius, despite it being affected by molecular outflow activity. We attribute this to the fast condensation of SiO back onto dust grains and/or rapid gas-phase destruction of SiO, which is favored by the high density present in this area ( cm−3). Finally, we identify a peripheral, narrow-line (∼2 km s−1) component where SiO has an abundance of a few times 10−11. After considering different options, we conclude that this weak emission may be tracing protostellar shocks from the star formation episode that preceded the current one, which have decelerated over time and eventually resulted in SiO being largely depleted/destroyed. Alternatively, a population of unresolved, low-mass protostars may be responsible for the narrow SiO emission. High-angular resolution observations are necessary to distinguish between these two possibilities, and thus to understand the role of SiO as a chemical tracer of past star formation episodes in massive protoclusters.
Discovery, Biosynthesis and Biological Activity of a Succinylated Myxochelin from the Myxobacterial Strain MSr12020

Myxobacteria feature unique biological characteristics, including their capability to glide on the surface, undergo different multicellular developmental stages and produce structurally unique natural products such as the catecholate-type siderophores myxochelins A and B. Herein, we report the isolation, structure elucidation and a proposed biosynthesis of the new congener myxochelin B-succinate from the terrestrial myxobacterial strain MSr12020, featuring a succinyl decoration at its primary amine group. Myxochelin-B-succinate exhibited antibacterial growth inhibition and moderate cytotoxic activity against selected human cancer cell lines. This unique chemical modification of myxochelin B might provide interesting insights for future microbiological studies to understand the biological function and biosynthesis of secondary metabolite succinylation.
Over-the-Air Max-Consensus in Clustered Networks Adopting Half-Duplex Communication Technology

This work considers a network of autonomous agents that exploit the superposition property of the wireless channel for achieving max-consensus under communication constraints. In technical applications, superposition (or interference) is traditionally avoided by physically separating transmissions from different agents, e.g., by employing time-division multiple access or frequency-division multiple access protocols. In contrast, Over-the-Air computation relies on simultaneous transmissions of signals in the same frequency band to boost performance. This article extends the results presented by Molinari et al. 2021 in a significant way: Rather than requiring a new and hardly accessible technology that allows simultaneous receiving and transmission of signals (full-duplex), we present a solution based on cheap and ubiquitous half-duplex technology. However, half-duplex technology only allows agents to either receive or transmit at a given time, hence requiring agents to be grouped into clusters. The proposed method, first, enables each cluster to achieve max-consensus within itself. Then, agents belonging to more than one cluster spread the information across different clusters that are, in general, not synchronized. The proposed max-consensus protocol can deal with asynchronism and allows the network to achieve max-consensus within a finite number of steps. Simulations confirm our theoretical results.