Miracle-dz/UniFAR-FTUs huggingface dataset:
North American Ecotourists: Market Profile and Trip Characteristics

This article is the first in a two-part series that presents the results of comprehensive, practical, primary research on ecotourism markets. The assessment provides information on markets, trip characteristics, motivation, product preferences, and overall demand. This part focuses on market and trip characteristics, including party size, spending, preferred season, and trip length.
Explaining Real Exchange Rate Fluctuations

This paper attempts to explain the sources of real exchange rate fluctuations for a set of advanced economies and Central and Eastern European transition economies. To that end, we first estimate structural (identified) vector autoregression (SVAR) models, and decompose real and nominal exchange rate movements into those caused by real and nominal shocks. We then complete the previous step with an impulse-response analysis. There is evidence of instability in the variance decomposition of the real exchange rates for advanced economies across samples, with a growing importance of nominal shocks. Nominal shocks are also important in some transition economies.
The precariousnesses of young knowledge workers: a subject-oriented approach

Over the past decades, a number of EU member states have recorded large rises in the use of temporary employment. Young people are far more likely than other groups to be employed in precarious jobs, independently of their education and skills. In the midst of the global economic-financial crisis, in fact, the assault on the conditions of knowledge workers goes on, according to the different lines of the neoliberalistic logics, which juxtapose with the current precarisation processes like underpayment and misalignment between subjects’ educations and their working activities. How do young precarious knowledge workers recount their experiences? What relation holds between a high education level and the possibility of effectively deploying the competences and skills acquired? How do knowledge workers represent and deal with their precarious conditions? To answer these questions, this article proposes a definition of the concepts of ‘precarity’, ‘precariousness’ and ‘precariat’ and then focuses specifically .
Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice

Particular major histocompatibility complex (MHC) class II alleles clearly contribute to T cell-mediated autoimmune type 1 diabetes (T1D) in both humans and nonobese diabetic (NOD) mice. However, studies in NOD mice indicate MHC class I-restricted T cell responses are also essential to T1D development. In humans, epidemiological studies have suggested that some common class I alleles, including HLA-A2.1 (A*02011), may confer increased susceptibility to T1D when expressed in conjunction with certain class II alleles. We show here that when HLA-A2.1 molecules are transgenically expressed in NOD mice, A2-restricted T cell responses arise against pancreatic β cells, leading to an earlier onset of T1D. The accelerated onset of T1D in the NOD.HLA-A2.1 transgenic mice is not due to nonspecific effects of expressing a third class I molecule, because a stock of NOD mice transgenically expressing HLA-B27 class I molecules showed no such acceleration of T1D, but rather were significantly protected from disease. These findings provide the first functional evidence that certain human MHC class I molecules can contribute to the development of T1D.
Towards pioneering through capabilities in dense and cohesive social networks

Purpose – This paper seeks to examine how dense and cohesive social networks can lead to pioneering. In this sense, the specific aim of this study is to analyse the mediating role placed by marketing and technological capabilities to explain the link among the structural social capital and the pioneering.Design/methodology/approach – Focusing on a sample of 224 companies from the Spanish footwear industry, the authors used partial least squares (PLS) with PLS‐Graph software to analyse data.Findings – The obtained results show how those firms with a dense and strong social network tend to develop pioneering. In this sense, a positive and significant relationship is found between structural social capital and pioneering. Furthermore, a strong positive relationship is found between structural social capital and marketing and technological capabilities, and of both kinds of capabilities with pioneering. The study also finds that the significant relationship between structural social capital and pioneering dis.
Determinants of glomerular hypofiltration in aging humans.

BACKGROUND The purpose of the present study was to confirm the extent to which glomerular filtration rate (GFR) is depressed in healthy, aging subjects and to elucidate the mechanism of such hypofiltration. METHODS Healthy volunteers aged 18 to 88 years (N = 159) underwent a determination of GFR, renal plasma flow (RPF), afferent oncotic pressure, and arterial pressure. Glomeruli in renal biopsies of healthy kidney transplant donors aged 23 to 69 years (N = 33) were subjected to a morphometric analysis, so as to determine glomerular hydraulic permeability and filtration surface area. The aforementioned GFR determinants were then subjected to mathematical modeling to compute the glomerular ultrafiltration coefficient (Kf) for two kidneys and individual glomeruli. RESULTS GFR was significantly depressed (P < 0.0001) by 22% in aging (>or=55 years old) compared to youthful subjects (<or=40 years old). Corresponding reductions of the following GFR determinants in the aging vs. youthful subsets were RPF by 28% (P < 0.0001), two-kidney Kf by 21% to 53% (P < 0.005), glomerular hydraulic permeability by 14% (P = 0.03), and the single-nephron Kf (SNKf) by 30% (P = 0.09). There were no significant differences between aging and youthful subsets for afferent oncotic pressure and filtration surface area per glomerulus. CONCLUSION We conclude that a reduction in overall, two-kidney Kf contributes to GFR depression in aging subjects. We infer that this is due in part to structural changes that lower SNKf, and in part to the reduction in the actual number of functioning glomeruli that has been demonstrated by others at autopsy.
A Note on the Most-Favoured-Customer Pricing Policy

This paper extends the retroactive most-favoured-customer pricing policy examined by Cooper (1986). He showed that the policy enabled both firms in a duopoly to offer higher prices and to enjoy higher profits. This paper introduces a variable into the most-favoured-customer pricing policy. Then, it shows that there is an equilibrium in which the duopolists can further increase their profits.
The Importance of Trade and Geography in the Pattern of Spatial Dependence of Growth Rates

The paper examines the nature of spatial dependence of growth rates across countries. Economic space as well as geographic space is considered as a possible medium through which growth rates may be correlated. The results indicate that the growth rates of developing countries are influenced by the lagged growth rates of their trading partners' growth rates. Industrialized countries' growth rates, on the other hand, display only contemporaneous correlation with others' growth rates that can be explained by the presence of time-specific global shocks. The conclusions seem consistent with a general model of North-South trade with endogenous knowledge-generated growth in the North and imitation, trade-driven growth in the South. Copyright 2002 by Blackwell Publishing Ltd
Respiratory muscle pressures in non-CF bronchiectasis: Repeatability and reliability

Background: Respiratory muscle strength is used diagnostically in clinical practice and as an outcome measure in clinical trials in various chronic lung diseases. There is limited data on its repeatability in people with non-CF bronchiectasis. The aim of the present study was to assess the repeatability of maximal inspiratory (P Imax) and expiratory pressures (PEmax) in a group of patients with stable, moderate-to-severe non-CF bronchiectasis. Methods: Twenty participants with stable moderate-to-severe non-CF bronchiectasis were recruited. Respiratory muscle strength measurements (three maximal inspiratory and expiratory pressures) were made on 2 separate days. A standard protocol was used, including practice tests, before obtaining three technically acceptable and reproducible readings with a difference of 10% or less between values. Clinical trial registration number: ClinicalTrials.gov: NCT00487149. Results: The mean (SD) age of the non-CF bronchiectasis group was 63 (9) years. Maximal inspiratory pressures were repeatable with mean (SD) for highest PImax, Test 1 and Test 2, 75.90 (20) and 79.40 (19) cmH2O, and limits of agreement (mean difference ± 2SD) —3.50 ± 20 cmH2O, (p = 0.14). Maximal expiratory pressures differed significantly with mean (SD) for highest PEmax, Test 1 and Test 2, 102.25 (27) and 112.30 (32) cmH 2O, and limits of agreement (mean difference ± 2SD) —10.10 ± 35 cmH2O, (p = 0.02). The intraclass correlation coefficient (95% CI) for highest PImax and PEmax was 0.93 (95% CI 0.82 to 0.97) and 0.90 (95% CI 0.76 to 0.96), respectively. Conclusion: Maximal inspiratory pressure measurements were repeatable during a period of clinical stability in moderate-to-severe non-CF bronchiectasis, suggesting this may be a useful outcome measure in non-CF bronchiectasis. Once a baseline has been established, a second visit is not required. PEmax was not a repeatable measure and further study is necessary to ascertain how much practice testing is required to obtain an accurate value.
Learning Predictive Movement Models From Fabric-Mounted Wearable Sensors

The measurement and analysis of human movement for applications in clinical diagnostics or rehabilitation is often performed in a laboratory setting using static motion capture devices. A growing interest in analyzing movement in everyday environments (such as the home) has prompted the development of “wearable sensors”, with the most current wearable sensors being those embedded into clothing. A major issue however with the use of these fabric-embedded sensors is the undesired effect of fabric motion artefacts corrupting movement signals. In this paper, a nonparametric method is presented for learning body movements, viewing the undesired motion as stochastic perturbations to the sensed motion, and using orthogonal regression techniques to form predictive models of the wearer's motion that eliminate these errors in the learning process. Experiments in this paper show that standard nonparametric learning techniques underperform in this fabric motion context and that improved prediction accuracy can be made by using orthogonal regression techniques. Modelling this motion artefact problem as a stochastic learning problem shows an average 77% decrease in prediction error in a body pose task using fabric-embedded sensors, compared to a kinematic model.
Kidney function in an unselected lithium population

ABSTRACT– We studied kidney function in 124 short‐term and long‐term lithium outpatients from a population of 127 patients. Glomerular and distal tubular function were measured and correlated with a number of demographic and treatment variables. There was a significant negative correlation between age and glomerular filtration rate. There were no other significant correlations. Tubular function was below normal in 51 % of the patients. Glomerular function was below normal in 3 % of the patients. We conclude that lithium treatment in non‐toxic dose affects kidney function and that tubular function is more affected than glomerular function. Tubular function probably is better than our figures indicate, glomerular function not as good. Types of lithium preparation do not affect kidney function differently nor does combined treatment with neuroleptics.
Autonomic nervous system responses during sedative infusions of dexmedetomidine.

BACKGROUND The purpose of this study was to determine the effects of dexmedetomidine on systemic and cardiac autonomic reflex responses during rest and during thermal stress. METHODS Volunteers received either placebo or low- or high-dose dexmedetomidine (target plasma concentrations 0.3 or 0.6 ng/ml, respectively) infusions in a prospectively randomized, double-blinded crossover study design. After 1 h, baroreflex sensitivity was assessed, and then core body temperature was raised to the sweating threshold and then lowered to the shivering threshold. Plasma catecholamines and blood pressure were measured, and cardiac autonomic responses were assessed by analysis of heart rate variability. RESULTS Compared with placebo, plasma norepinephrine concentrations, blood pressure, heart rate, and some heart rate variability measures were lower after 1-h infusion of dexmedetomidine, but baroreflex responses did not differ significantly. Dexmedetomidine blunted the systemic and cardiac sympathetic effects of sweating observed during placebo infusion but had no effect on parasympathetic measures. Increases in blood pressure, and systemic catecholamines due to shivering were observed during placebo and dexmedetomidine, but these responses were less with dexmedetomidine. During shivering, dexmedetomidine infusion was associated with higher low-frequency and high-frequency heart rate variability power but lower heart rate compared with the sweating threshold and with the control period, suggesting nonreciprocal cardiac autonomic responses. CONCLUSIONS Infusion of dexmedetomidine results in compensated reductions in systemic sympathetic tone without changes in baroreflex sensitivity. Dexmedetomidine blunts heart rate and the systemic sympathetic activation due to sweating, but it is less effective in blunting cardiac sympathetic responses to shivering. During dexmedetomidine infusion, cardiac sympathetic and parasympathetic tone may have nonreciprocal changes during shivering.
Decreased interferon-alpha production in HIV-infected patients correlates with numerical and functional deficiencies in circulating type 2 dendritic cell precursors.

Peripheral blood mononuclear cells from patients with human immunodeficiency virus (HIV) infection exhibit a progressively marked decrease in the production of virus-induced interferon (IFN)-alpha, a finding that correlates with and is highly predictive of disease progression and opportunistic infections. The major IFN-alpha producing population has recently been defined as the precursor to type 2 dendritic cells (pDC2) or plasmacytoid DC (pDC). Using four-color flow cytometry, we have enumerated the pDC2 vs non-IFN-alpha producing myeloid DC1 in peripheral blood from HIV-infected patients and healthy controls and related these values to CD4 cell numbers, viral load, and functional activity. The patients had reductions in the numbers of both pDC2 (lin-/HLA-DR+/CD123(bright)) and DC1 (lin1-/HLA-DR+/CD123(dim)/CD11c+), both at an absolute level and as a percentage of cells. The decreases were most evident in patients with decreased CD4 levels. Viral load correlated with the functional frequency of the IFN producing cells but not with absolute pDC2 levels. Using intracellular flow cytometric analysis for IFN-alpha, the patients were demonstrated to have fewer pDC2, as well as a lower percentage of responding cells among those remaining. We conclude that deficient production of IFN-alpha by pDC2 from HIV-infected patients results from both selective loss of these cells and their qualitative dysfunction. Given the central role of DC, and in particular, DC2, in linking innate and adaptive immune responses, these qualitative and quantitative changes in pDC2 are likely to be key contributors to HIV pathogenesis.
Performance Contracts and Goal Attainment in Government Agencies

ABSTRACT Public sector reforms introducing performance contracts provide a unique opportunity to investigate goals set for government agencies and factors affecting goal attainment. The article maps the set of goals contained in performance contracts for Danish government agencies in 2000, 2005, and 2008. Performance contracts are found to reflect the complex character of agency goals with performance goals ranging from project initiation to reducing case work time or increasing productivity. The article also analyzes factors affecting goal attainment. Agencies with a large percentage of goals focused on project initiation and production exhibit higher levels of goal attainment. Also, goal attainment improves as agencies and ministries gain experience with performance contracts. For practitioners, it is relevant that contracts target a wide variety of goals and over time focus increasingly on results. Contracts serve to focus agency attention as three quarters of all demands are met. A crucial factor seems to be whether agencies are in control of formulating and meeting goals. Efforts to improve the contract regime may thus concentrate on enabling government departments to secure ambitious and relevant performance goals.
A systematic review of the behavioural outcomes following exercise interventions for children and youth with autism spectrum disorder

The purpose of this review was to systematically search and critically analyse the literature pertaining to behavioural outcomes of exercise interventions for individuals with autism spectrum disorder aged ⩽16 years. This systematic review employed a comprehensive peer-reviewed search strategy, two-stage screening process and rigorous critical appraisal, which resulted in the inclusion of 13 studies. Results demonstrated that exercise interventions consisting individually of jogging, horseback riding, martial arts, swimming or yoga/dance can result in improvements to numerous behavioural outcomes including stereotypic behaviours, social-emotional functioning, cognition and attention. Horseback riding and martial arts interventions may produce the greatest results with moderate to large effect sizes, respectively. Future research with well-controlled designs, standardized assessments, larger sample sizes and longitudinal follow-ups is necessary, in addition to a greater focus on early childhood (aged 0–5 years) and adolescence (aged 12–16 years), to better understand the extent of the behavioural benefits that exercise may provide these populations.
Growth in Sub-Saharan Africa

The paper investigates empirically the determinants of per capita economic growth for a large sample of sub-Saharan African countries during 1981-92. The results indicate that (1) an increase in private investment has a relatively large positive impact on per capita growth; (2) growth is stimulated by public policies that lower the budget deficit in relation to GDP (without reducing government investment), reduce the rate of inflation, maintain external competitiveness, promote structural reforms, encourage human capital development, and slow population growth; and (3) per capita income converges after controlling for human capital development and public policies.
05 03 10 0 v 3 29 S ep 2 00 5 Picture-Invariance in Quantum Optics

We clarify the controversy over coherent-state (CS) versus number-state (NS) pictures in quantum optics. The NS picture is equivalent to the CS picture, as long as phase φ in laser fields are randomly distributed, as Mølmer argues. However, claim by Rudolph and Sanders [Phys. Rev. Lett. 87, 077903 (2001)] has a few gaps. First they make an assumption that is not necessarily true in calculation of a density operator involved with two-mode squeezed state. We show that there exists entanglement in the density operator without defying the assumption that phases are randomly distributed. Moreover, using a concept of picture-invariance, we argue that it is not that criteria for quantum teleportation are not satisfied. We discuss an analogy between the controversy on the CS versus NS pictures to that on the heliocentric versus geocentric pictures. PACS: 03.65. Ud, 03.67. -a, 03.67. Dd, 42.50. -p, 42.50. Ar
Retinoic Acid Imprints a Mucosal-like Phenotype on Dendritic Cells with an Increased Ability To Fuel HIV-1 Infection

The tissue microenvironment shapes the characteristics and functions of dendritic cells (DCs), which are important players in HIV infection and dissemination. Notably, DCs in the gut have the daunting task of orchestrating the balance between immune response and tolerance. They produce retinoic acid (RA), which imprints a gut-homing phenotype and influences surrounding DCs. To investigate how the gut microenvironment impacts the ability of DCs to drive HIV infection, we conditioned human immature monocyte-derived DCs (moDCs) with RA (RA-DCs), before pulsing them with HIV and mixing them with autologous T cells. RA-DCs showed a semimature, mucosal-like phenotype and released higher amounts of TGF-β1 and CCL2. Using flow cytometry, Western blot, and microscopy, we determined that moDCs express the cell adhesion molecule mucosal vascular addressin cell adhesion molecule-1 (MAdCAM-1) and that RA increases its expression. MAdCAM-1 was also detected on a small population of DCs in rhesus macaque (Macaca mulata) mesenteric lymph node. RA-DCs formed more DC–T cell conjugates and promoted significantly higher HIV replication in DC–T cell mixtures compared with moDCs. This correlated with the increase in MAdCAM-1 expression. Blocking MAdCAM-1 partially inhibited the enhanced HIV replication. In summary, RA influences DC phenotype, increasing their ability to exacerbate HIV infection. We describe a previously unknown mechanism that may contribute to rapid HIV spread in the gut, a major site of HIV replication after mucosal exposure.
Do alternative methods of reporting non-controlling interests really matter?

Researchers have long been interested in whether the classification of various items on the balance sheet matters to investors. This paper provides evidence on whether reporting non-controlling interests (NCI) as equity or as non-equity matters in terms of value relevance. We use a sample of German firms that voluntary adopted International Financial Reporting Standards early. This adoption required them to change their reporting of NCI from the non-equity to the equity portion of the balance sheet. After conducting sensitivity tests for self-selection bias and controlling for weight of NCI, firm size and leverage, our results suggest that NCI are priced by the market in the same manner irrespectively of being reported as equity or non-equity. This finding reinforces the notion that equity markets are efficient in their processing of information, regardless of the classification by standard setters. JEL Classification: M41-Accounting.
Diaquabis(cyclohexanecarboxylato)zinc(II) monohydrate

In the title compound, [Zn(C7H11O2)2(H2O)2]·H2O, the ZnII atom (site symmetry ) is four-coordinated by two O atoms from the cyclohexanecarboxylate anions and two O atoms from the water molecules, forming a slightly distorted square-planar coordination. The O atom of the uncoordinated water molecule lies on a crysatllographic twofold rotation axis. In the crystal, the components are linked by O—H⋯O hydrogen bonds, forming a three-dimensional network.