Miracle-dz/UniFAR-FTUs huggingface dataset:
A brain imaging study of dopamine receptor D2 availability in cannabis dependent users after recovery from cannabis-induced psychosis

There is increased risk of psychosis associated with cannabis use disorder and the interaction of THC with dopamine neurotransmission is complex. It is important to investigate the recovery from cannabis-induced psychosis and its effects on the brain’s dopamine neurotransmission. This study was to evaluate dopamine receptor D2 availability in the striatum (caudate/putamen) in recently abstinent cannabis dependent users after recovery from psychosis in comparison with abstinent MDMA “ecstasy” abusers and healthy control participants. Participants were eight abstinent ex cannabis-dependent users who were treated for cannabis-induced psychosis with anti-psychotic medication and psychosocial support for 4 months in an inpatient treatment center for drug users. They were compared with nine abstinent ex MDMA “ecstasy” abusers who received medication and psycho-social treatment for 4 months at the same treatment facility and eight healthy control participants. All participants were scanned with bolus and constant infusion of [123I] Iodobenzamide (IBZM) in Single Photon Computed Tomography (SPECT). Cannabis abstinent users who were treated for cannabis-induced psychotic episodes showed no difference in dopamine D2 receptor availability in the caudate compared with abstinent MDMA “ecstasy” abusers and healthy control participants. This finding indicates minimal effects of cannabis-induced psychosis on dopamine reward mechanisms. There is evidence for reduced D2 receptor availability measures in the right putamen (uncorrected) which may indicate a residual effect of anti-psychotic medication.
Granite and granitic pegmatite melts: volumes and viscosities

ABSTRACT: Progress in the understanding of the volumes and viscosities of granitic and related pegmatitic melts generated by experimental studies are reviewed. The results of a series of investigations of the volumes and viscosities of melts derived from a haplogranitic base composition, HPG8, located near the 2 kbar water-saturated minimum melt composition in the albite—orthoclase—silica system are discussed. Melt volumes, obtained using a combination of dilatometric and calorimetric methods at 1 atm and relatively low temperatures yield an internally consistent set of partial molar volumes for 18 components in granitic melts. These partial molar volumes, combined with an estimate for water, allow the estimation of melt densities for granitic and related pegmatitic magmas. Melt viscosities, obtained using a combination of high and low range viscometry techniques, provide a template for the estimation of melt viscosities in more complex natural systems. The parameterisation of the non-Arrhenian temperature-dependence of the viscosity of such melts is presented, together with some structural implications of the variation of melt viscosity with temperature and composition. Outstanding questions related to the PVT equation of state of granitic melts and to the mechanical response to shear stresses are discussed, with an outlook for the experimental solutions to those questions in the next few years.
Vegetation Identification and Biomass Estimation Using AIRSAR Data

Abstract Monitoring of vegetation biomass is becoming more important as countries attempt to preserve major carbon reservoirs. We examine the potential use of radar information to quantify forest biomass and classify vegetation type based on data from the New Zealand segment of the 1996 Pacific Rim AIRSAR campaign. Two different types of vegetation were measured: plantation forestry and indigenous scrub. A very significant statistical relationship was found between plantation forestry biomass and measurements derived from AIRSAR data. However, for scrub vegetation, no relationship was found, possibly due to the very small number of ground samples used. In order to separate these vegetation classes from other cover types, two classification procedures, based on the polarimetric characteristics of the backscatter, were trialed. Both approaches produced good classification accuracies for the cover types of interest.
Inferential evaluation and revision in L1 and L2 text comprehension: An eye movement study

Text comprehension frequently demands the resolution of no longer plausible interpretations to build an accurate situation model, an ability that might be especially challenging during second language comprehension. Twenty-two native English speakers (L1) and twenty-two highly proficient non-native English speakers (L2) were presented with short narratives in English. Each text required the evaluation and revision of an initial prediction. Eye movements in the text and a comprehension sentence indicated less efficient performance in the L2 than in L1 comprehension, in both inferential evaluation and revision. Interestingly, these effects were determined by individual differences in inhibitory control and linguistic proficiency. Higher inhibitory control reduced the time rereading previous parts of the text (better evaluation) as well as revisiting the text before answering the sentence (better revision) in L2 comprehenders, whereas higher proficiency reduced the time in the sentence when the story was coherent, suggesting better general comprehension in both languages.
Holocene buried organic sediments in Estonia

An overview of 85 sites of Holocene buried organic sediments in Estonia is presented. This number includes 45 sites of pre-Ancylus and Ancylus age, which were buried during the Ancylus transgression, 31 sites of pre-Litorina and Litorina age, buried under Litorina transgression sediments, and 9 sites formed after post-Litorina time and mostly covered by aeolian sand. According to radiocarbon dates, the Ancylus Lake transgression started about 9500 yr BP (10 800 cal BP), and culminated several hundred years later. Around 9000 yr BP (10 100 cal BP) a rather rapid regression followed. Its magnitude reached up to 30 m in the areas of rapid uplift. Pollen spectra of these beds are characterized by a high frequency of Pinus pollen, which seems to be typical of the coastal waterbodies of this age and confuses determination of their Preboreal age. 14 C dates of Litorina buried beds differ considerably. We have evidence that the Litorina transgression started about 7500-7000 yr BP (8300-7800 cal BP) and culminated at different times in different regions. Pollen spectra of Litorina buried organic strata vary considerably between sites; however, their Atlantic age is easily discernible. The simulated isobases of the Ancylus Lake and Litorina Sea shorelines and organic beds showed discrepancy in the surroundings of Parnu and Narva bays.
Anifrolumab for Moderate and Severe Muco-Cutaneous Lupus Erythematosus: A Monocentric Experience and Review of the Current Literature

Refractory cutaneous manifestations constitute a significant unmet need in patients with cutaneous lupus (CLE), even in the setting of systemic lupus erythematosus (SLE) with otherwise good control of inflammatory manifestations. Anifrolumab, an anti-interferon I receptor monoclonal antibody has recently been approved for serologically positive SLE with or without CLE, but real-life efficacy and safety data are currently limited. In addition, relatively limited evidence exists about the spectrum of cutaneous manifestations potentially benefitting from anifrolumab treatment and about the optimal clinimetrics to monitor treatment efficacy. While summarising current evidence on the topic in the literature, we report on four patients with SLE and refractory CLE who were successfully treated with anifrolumab. We also describe the potential usefulness and complementarity of the cutaneous lupus activity investigator’s global assessment (CLA-IGA) in assessing cutaneous activity in patients treated with anifrolumab.
Sporothrix brasiliensis Infection Modulates Antimicrobial Peptides and Stress Management Gene Expression in the Invertebrate Biomodel Galleria mellonella

Sporothrix brasiliensis is the most pathogenic species, responsible for the Brazilian cat-transmitted sporotrichosis hyperendemic. In this scenario, an investigation of the pathogen–host interaction can provide relevant information for future treatment strategies. To this end, the invertebrate Galleria mellonella has proven to be a suitable alternative for evaluating the virulence of pathogenic fungi, since the insect immune system is similar to the mammalian innate immune response. The aim of this work was to investigate phenotypic and molecular aspects of the immune response of G. mellonella throughout the S. brasiliensis infection. Hemocyte density and the evolution of the fungal load were evaluated. In parallel, RT-qPCR expression analysis of genes encoding antimicrobial peptides (Gallerimycin and Galiomycin) and stress management genes (C7 Contig 15362 and C8 Contig 19101) was conducted. The fungal load and hemocyte densities increased simultaneously and proportionally to the deleterious morphological events and larvae mortality. Gallerimycin, C7 Contig 15362 and C8 Contig 19101 genes were positively regulated (p < 0.05) at distinct moments of S. brasiliensis infection, characterizing a time-dependent and alternately modulated profile. Galiomycin gene expression remained unchanged. Our results contribute to the future proposal of potential alternative pathways for treating and consequently controlling S. brasiliensis zoonosis, a major public health issue in Latin America.
Regions with Altered Degree Centrality and Their Functional Connectivity in First-Episode Drug-Naïve Major Depressive Disorder: A Resting-State Functional Magnetic Resonance Imaging Study

Objective: The aim of this study was to identify regions with altered degrees of centrality (DC) and changes in their functional connectivity (FC) in first-episode drug-naïve major depressive disorder (FEDN-MDD) patients using resting-state functional magnetic resonance imaging (fMRI). Methods: The study included 74 FEDN-MDD patients who met the study criteria and 41 healthy controls (HCs). All had undergone fMRI scanning in the resting condition. To evaluate differences between FEDN-MDD patients and HCs, we first compared the DC between the 2 groups. The DC regions with the most significant differences were then taken as seeds, and their FC was calculated. Results: Right posterior cingulum cortex (PCC.R), right precuneus (PCUN.R), and right putamen (PUT.R) all showed significantly different DC values (P < .001) between FEDN-MDD patients and HC groups, which helped in distinguishing these groups. The PUT.R in FEDN-MDD patients showed increased FC (P < .001) with the right inferior temporal gyrus and right inferior occipital gyrus compared to HC. Moreover, the PCUN.R in FEDN-MDD patients showed decreased FC (P < .001) with bilateral cerebellum crus I, left cerebellum crus II, bilateral orbital medial frontal gyrus, right superior medial frontal gyrus, left precuneus, left posterior cingulum cortex, right superior frontal gyrus, and PCC.R compared with the HC group. The P-values for cluster testing were . 050, while for voxel testing they were . 001. Conclusion: These findings imply that PUT.R, PCUN.R, and PCC.R serve as the core brain net hub in FEDN-MDD patients, and their FC displays aberrant function. This may involve a specific psychiatric neuropathology associated with FEDN-MDD.
Validación de una estrategia metodol ógica para la evaluación cualitativa de un pastizal mediano abierto del estado de Zacatecas Validation of a methodological strategy for the qualitative evaluation of semiarid rangelands in Zacatecas

Rangeland degradation due to mismanagement practices in the extensive system for cattle and the need for monitoring rangelands continuously, leads to seek for methodologies which may be easily and quickly applied. In order to accomplish such objectives, methodologies must be based upon qualitative indicators. Such methodology has been applied broadly using 17 indicators that represent soil, water and vegetation attributes. This study was carried out in the State of Zacatecas and included 34 sites located randomly in the grassland with four repetitions by site. Data was analysed by principal components and a semivariogram and maps were generated by Kriging. Further, maps were compared to reference maps, which were calculated by quantitative methods. First map was associated to rangelands general health condition. The reference map was estimated from NDVI values. The second component refers to runoff, and the third component was associated to water erosion induced by bare soil. Those two were compared to reference maps estimated from mathematical models. Coincidences among maps were as 59.2, 31.2 y 17.2 %, which were the variance values estimated by principal components, and allowed to validate correspondence between them. Categorical data were not different (P>0.05). Low cost and easy methods are helpful and should be validated for use them when no other methods are available.
Pregnancy in autistic women and social medical considerations: scoping review and meta- synthesis

Introduction This article addresses a topic that has been largely overlooked by scientific literature, namely pregnancy in autistic women. Generally, the issue of sexuality in disability, particularly in disabled women, autistic or otherwise, has been underexplored. However, it is necessary to scientifically investigate this topic to propose adequate social and health policies. Therefore, we chose to conduct a scoping review to answer three main questions: “What does it mean for an autistic woman to be pregnant? ”; “How do these two conditions coexist? ”; “Are health services prepared to receive this population adequately or does autism become a stigma for pregnant women? ” Methods We conducted a systematic review and qualitative thematic synthesis following the Preferred Reporting Guidelines for Systematic Reviews and Meta-Analyses on autistic women and pregnancy in the last 10 years. Results The studies included in our review are 7, extremely diverse in terms of methodologies and sample sizes. Despite the heterogeneity of samples and methodologies, all research tends to highlight the following results. For autistic women during pregnancy, three areas seem to be the most difficult: sensory issues, mood disorders, and relationships with specialists. Discussion Our study found that women with ASD face unique challenges during childbirth that differ from those of neurotypical women. Participants often felt belittled, ignored, and uninformed about the care they received, and being placed at the centre of attention was often seen as negative and hindering rather than positive. However, the research shows us how some “expected” results, such as difficulties in breastfeeding, have been disproven.
Cognitive Risk Control for Physical-Layer RFID Counterfeit Tag Identification

Physical-layer counterfeit tag identification is a widely adopted technology for detecting clone tags in radio-frequency identification (RFID) systems. It has gained significant attention in recent years owing to its affordability and ease of implementation. However, the effectiveness of physical-layer identification technology is highly dependent on the tag identification environment. When the reading distance is far or signal power is low, the signal-to-noise ratio (SNR) of the tag signal may be low, leading to a degradation in classification accuracy. To address the issue, this article explores the application of cognitive risk control (CRC) in tag classification, aiming to enhance the SNR and improve classification accuracy. Additionally, this article introduces more time- and frequency-domain features, resulting in a total of 104 features, to further enhance the classification performance. The experiment utilizes a software radio device to classify tags from three manufacturers across seven popular types. The results indicate that the implementation of CRC has, on average, improved the classification accuracy of the tags by approximately eight percentage points. Moreover, when compared to traditional 28 and seven features, the use of 104 features has shown an average increase in classification accuracy of about two and four percentage points, respectively.
Regular Exercise Improved Fatigue and Musculoskeletal Pain in Young Adult Psoriatic Patients without Psoriatic Arthritis

Fatigue and musculoskeletal pain are also frequent in patients with psoriasis (PsO) without arthritis (PsA). The current study aimed to assess the impact of an intervention program based on aerobic training to reduce fatigue and musculoskeletal pain in patients with PsO without PsA. A total of 118 male patients with PsO volunteered in the current interventional study and were randomly allocated to the experimental (n = 59) or control group (n = 59). The intervention consisted of a 16-week aerobic training program on a treadmill, three sessions per week, consisting of a warm-up, 35–50 min treadmill exercise (increasing 5 min/4 weeks) at a work intensity of 50–65% of peak heart-rate (increasing 5%/4 weeks), and cooling-down. The functional assessment of chronic illness therapy fatigue scale (FACIT-Fatigue), health assessment questionnaire disability index (HAQ-DI), and visual analog scale (VAS) were compared pre and post intervention. Nutritional intake, maximal aerobic power, lipid profile, serum markers of muscle damage, and body composition were also assessed. When compared to baseline, FACIT-Fatigue, HAQ-DI, and VAS scores were significantly improved without increasing markers of muscle damage. Fat mass percentage, lipid profile, and maximal oxygen consumption were also improved. In conclusion, a 16-week aerobic training program at moderate intensity was safe, well tolerated, and effective in psoriatic patients without PsA. Long-term follow-up studies are required to examine whether these promising results may improve clinical outcomes.
CRISPR-based bioengineering in microalgae for production of industrially important biomolecules

Microalgae, as photosynthetic organisms, have the potential to produce biomolecules for use in food, feed, cosmetics, nutraceuticals, fuel, and other applications. Faster growth rates and higher protein and lipid content make microalgae a popular chassis for many industrial applications. However, challenges such as low productivity and high production costs have limited their commercialization. To overcome these challenges, bioengineering approaches such as genetic engineering, metabolic engineering, and synthetic biology have been employed to improve the productivity and quality of microalgae-based products. Genetic engineering employing genome editing tools like CRISPR/Cas allows precise and targeted genetic modifications. CRISPR/Cas systems are presently used to modify the genetic makeup of microalgae for enhanced production of specific biomolecules. However, these tools are yet to be explored explicitly in microalgae owing to some limitations. Despite the progress made in CRISPR-based bioengineering approaches, there is still a need for further research to optimize the production of microalgae-based products. This includes improving the efficiency of genome editing tools, understanding the regulatory mechanisms of microalgal metabolism, and optimizing growth conditions and cultivation strategies. Additionally, addressing the ethical, social, and environmental concerns associated with genetic modification of microalgae is crucial for the responsible development and commercialization of microalgae-based products. This review summarizes the advancements of CRISPR-based bioengineering for production of industrially important biomolecules and provides key considerations to use CRISPR/Cas systems in microalgae. The review will help researchers to understand the progress and to initiate genome editing experiments in microalgae.
Influence of the ethical climate on workers' health among healthcare professionals: a systematic review.

OBJECTIVE To evaluate the influence of the ethical climate on workers' health among healthcare professionals. METHOD Systematic review and meta-analysis conducted in MEDLINE/PubMed, EMBASE, SciVerse Scopus (Elsevier), Cumulative Index to Nursing and Allied Health Literature and Web of Science. Trained reviewers performed the selection, data extraction, and assessment of methodological quality. Meta-analysis was applied for data synthesis. RESULTS Among the 2644 studies, 20 were included for analysis, in which three (15.0%) articles were classified as high quality (score ≥ 80%), while 17 (85.0%) were classified as regular (score 50-79%). There was a moderate negative correlation between the ethical climate and overall moral distress (r=-0.43; 95%CI -0.50; -0.36) and the frequency of moral distress (r=-0.36; 95%CI -0.45; -0.25), as well as the positive and strong correlation between ethical climate and job satisfaction (r=0.71; 95%CI 0.39-0.88). CONCLUSION The negative and positive perception of the ethical climate among healthcare professionals, respectively, influenced the increase in moral distress and job satisfaction.
Structure-guided optimisation of N-hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α

The human 2-oxoglutarate (2OG)- and Fe(ii)-dependent oxygenases factor inhibiting hypoxia-inducible factor-α (FIH) and HIF-α prolyl residue hydroxylases 1–3 (PHD1–3) regulate the response to hypoxia in humans via catalysing hydroxylation of the α-subunits of the hypoxia-inducible factors (HIFs). Small-molecule PHD inhibitors are used for anaemia treatment; by contrast, few selective inhibitors of FIH have been reported, despite their potential to regulate the hypoxic response, either alone or in combination with PHD inhibition. We report molecular, biophysical, and cellular evidence that the N-hydroxythiazole scaffold, reported to inhibit PHD2, is a useful broad spectrum 2OG oxygenase inhibitor scaffold, the inhibition potential of which can be tuned to achieve selective FIH inhibition. Structure-guided optimisation resulted in the discovery of N-hydroxythiazole derivatives that manifest substantially improved selectivity for FIH inhibition over PHD2 and other 2OG oxygenases, including Jumonji-C domain-containing protein 5 (∼25-fold), aspartate/asparagine-β-hydroxylase (>100-fold) and histone Nε-lysine demethylase 4A (>300-fold). The optimised N-hydroxythiazole-based FIH inhibitors modulate the expression of FIH-dependent HIF target genes and, consistent with reports that FIH regulates cellular metabolism, suppressed lipid accumulation in adipocytes. Crystallographic studies reveal that the N-hydroxythiazole derivatives compete with both 2OG and the substrate for binding to the FIH active site. Derivatisation of the N-hydroxythiazole scaffold has the potential to afford selective inhibitors for 2OG oxygenases other than FIH.