Miracle-dz/UniFAR-FTUs huggingface dataset:
A Comparative Effectiveness Meta-Analysis of Drugs for the Prophylaxis of Migraine Headache

Objective To compare the effectiveness and side effects of migraine prophylactic medications. Design We performed a network meta-analysis. Data were extracted independently in duplicate and quality was assessed using both the JADAD and Cochrane Risk of Bias instruments. Data were pooled and network meta-analysis performed using random effects models. Data Sources PUBMED, EMBASE, Cochrane Trial Registry, bibliography of retrieved articles through 18 May 2014. Eligibility Criteria for Selecting Studies We included randomized controlled trials of adults with migraine headaches of at least 4 weeks in duration. Results Placebo controlled trials included alpha blockers (n = 9), angiotensin converting enzyme inhibitors (n = 3), angiotensin receptor blockers (n = 3), anticonvulsants (n = 32), beta-blockers (n = 39), calcium channel blockers (n = 12), flunarizine (n = 7), serotonin reuptake inhibitors (n = 6), serotonin norepinephrine reuptake inhibitors (n = 1) serotonin agonists (n = 9) and tricyclic antidepressants (n = 11). In addition there were 53 trials comparing different drugs. Drugs with at least 3 trials that were more effective than placebo for episodic migraines included amitriptyline (SMD: -1.2, 95% CI: -1.7 to -0.82), -flunarizine (-1.1 headaches/month (ha/month), 95% CI: -1.6 to -0.67), fluoxetine (SMD: -0.57, 95% CI: -0.97 to -0.17), metoprolol (-0.94 ha/month, 95% CI: -1.4 to -0.46), pizotifen (-0.43 ha/month, 95% CI: -0.6 to -0.21), propranolol (-1.3 ha/month, 95% CI: -2.0 to -0.62), topiramate (-1.1 ha/month, 95% CI: -1.9 to -0.73) and valproate (-1.5 ha/month, 95% CI: -2.1 to -0.8). Several effective drugs with less than 3 trials included: 3 ace inhibitors (enalapril, lisinopril, captopril), two angiotensin receptor blockers (candesartan, telmisartan), two anticonvulsants (lamotrigine, levetiracetam), and several beta-blockers (atenolol, bisoprolol, timolol). Network meta-analysis found amitriptyline to be better than several other medications including candesartan, fluoxetine, propranolol, topiramate and valproate and no different than atenolol, flunarizine, clomipramine or metoprolol. Conclusion Several drugs good evidence supporting efficacy. There is weak evidence supporting amitriptyline’s superiority over some drugs. Selection of prophylactic medication should be tailored according to patient preferences, characteristics and side effect profiles.
From cineradiography to biorobots: an approach for designing robots to emulate and study animal locomotion

Robots are increasingly used as scientific tools to investigate animal locomotion. However, designing a robot that properly emulates the kinematic and dynamic properties of an animal is difficult because of the complexity of musculoskeletal systems and the limitations of current robotics technology. Here, we propose a design process that combines high-speed cineradiography, optimization, dynamic scaling, three-dimensional printing, high-end servomotors and a tailored dry-suit to construct Pleurobot: a salamander-like robot that closely mimics its biological counterpart, Pleurodeles waltl. Our previous robots helped us test and confirm hypotheses on the interaction between the locomotor neuronal networks of the limbs and the spine to generate basic swimming and walking gaits. With Pleurobot, we demonstrate a design process that will enable studies of richer motor skills in salamanders. In particular, we are interested in how these richer motor skills can be obtained by extending our spinal cord models with the addition of more descending pathways and more detailed limb central pattern generator networks. Pleurobot is a dynamically scaled amphibious salamander robot with a large number of actuated degrees of freedom (DOFs: 27 in total). Because of our design process, the robot can capture most of the animal's DOFs and range of motion, especially at the limbs. We demonstrate the robot's abilities by imposing raw kinematic data, extracted from X-ray videos, to the robot's joints for basic locomotor behaviours in water and on land. The robot closely matches the behaviour of the animal in terms of relative forward speeds and lateral displacements. Ground reaction forces during walking also resemble those of the animal. Based on our results, we anticipate that future studies on richer motor skills in salamanders will highly benefit from Pleurobot's design.
The role of TGF-β1 869 T > C and PPAR γ2 34 C > G polymorphisms, fat mass, and anthropometric characteristics in predicting childhood obesity at birth

AbstractThis study proposed to establish a correlation between the risk score for child obesity and anthropometric, genetic, and bioimpedance characteristics in mothers and newborns, and to assess the discriminant ability for anthropometric parameters to classify over-fatness (defined by bioimpedance body fatness %) in pregnant women.We performed a cross-sectional study on 388 couples (mother and father) and their newborns admitted in a Tertiary Hospital from Romania. The measured parameters for mothers and their newborns were risk percentage for child obesity, anthropometric characteristics (mid-upper arm circumference [MUAC], tricipital skinfold thickness [TST] of mother and newborn), genetic polymorphisms (human peroxisome proliferator-activated receptor &ggr; [PPAR&ggr;2] 34 C > G and transforming growth factor-beta 1 [TGF-&bgr;1] 869 T > C gene polymorphisms in both mothers and newborns), and mother's bioimpedance characteristics (fat mass [FM] %). The obesity risk score according to standard predictable Northern Finland Birth Cohort equation was in our study 4.07%. We found a monotone positive significant correlation between the newborn's risk of childhood obesity and the mother's TST (P = 0.01), as well as a tendency toward statistical significance concerning correlation with mother's MUAC (P = 0.053), without any correlations with the mothers’ bioimpedance parameters and also a positive correlation between the newborn's risk of childhood obesity and the newborn's anthropometrical characteristics like body mass index (BMI), MUAC, and TST (P < 0.001). We observed that the calculated newborn's risk percentage for child obesity was greater for the variant allele of the TGF-&bgr;1 869 T > C polymorphism and also for the wild-type C allele of the PPAR&ggr;2 34 C > G gene polymorphism. Our study indicated that the best predictors for over-fatness are BMI and MUAC (P = 0.01 < 0.02 and P = 0.019 < 0.02, respectively).
Effects of gonadotropin-releasing hormone administration or a controlled internal drug-releasing insert after timed artificial insemination on pregnancy rates of dairy cows

This study investigated the effects of gonadotrophin-releasing hormone (GnRH) administration (Experiment 1) and a controlled internal drug-releasing (CIDR) insert (Experiment 2) after timed artificial insemination (TAI) on the pregnancy rates of dairy cows. In Experiment 1, 569 dairy cows that underwent TAI (day 0) following short-term synchronization with prostaglandin F2α were randomly allocated into two groups: no further treatment (control, n = 307) or injection of 100 µg of gonadorelin on day 5 (GnRH, n = 262). In Experiment 2, 279 dairy cows that underwent TAI (day 0) following Ovsynch were randomly allocated into two groups: no further treatment (control, n = 140) or CIDR insert treatment from days 3.5 to 18 (CIDR, n = 139). The probability of pregnancy following TAI did not differ between the GnRH (34.4%) and control (31.6%, p > 0.05) groups. However, the probability of pregnancy following TAI was higher (odds ratio: 1.74, p < 0.05) in the CIDR group (51.1%) than in the control group (39.3%). Overall, CIDR insert treatment at days 3.5 to 18 increased pregnancy rates relative to non-treated controls, whereas a single GnRH administration on day 5 did not affect the pregnancy outcomes of dairy cows.
Positive Relationship between Total Antioxidant Status and Chemokines Observed in Adults

Objective. Human evidence is limited regarding the interaction between oxidative stress biomarkers and chemokines, especially in a population of adults without overt clinical disease. The current study aims to examine the possible relationships of antioxidant and lipid peroxidation markers with several chemokines in adults. Methods. We assessed cross-sectional associations of total antioxidant status (TAS) and two lipid peroxidation markers malondialdehyde (MDA) and thiobarbituric acid reactive substances (TBARS) with a suite of serum chemokines, including CXCL-1 (GRO-α), CXCL-8 (IL-8), CXCL-10 (IP-10), CCL-2 (MCP-1), CCL-5 (RANTES), CCL-8 (MCP-2), CCL-11 (Eotaxin-1), and CCL-17 (TARC), among 104 Chinese adults without serious preexisting clinical conditions in Beijing before 2008 Olympics. Results. TAS showed significantly positive correlations with MCP-1 (r = 0.15751, P = 0.0014), MCP-2 (r = 0.3721, P = 0.0001), Eotaxin-1 (r = 0.39598, P < 0.0001), and TARC (r = 0.27149, P = 0.0053). The positive correlations remained unchanged after controlling for age, sex, body mass index, smoking, and alcohol drinking status. No associations were found between any of the chemokines measured in this study and MDA or TBARS. Similar patterns were observed when the analyses were limited to nonsmokers. Conclusion. Total antioxidant status is positively associated with several chemokines in this adult population.
Specification and Animation of Reactive Systems

SOLVE (Specification using an Object-based, LOTOS-defined, Visual language) is designed to allow formal requirements capture, particularly for reactive systems. The SOLVE language is object-based, and formally defined using LOTOS (Language Of Temporal Ordering Specification). SOLVE is supported by tools that allow direct visual animation of systems specified in this language. Animation is supported by translating a SOLVE specification automatically into a LOTOS specification, and then graphically simulating this. A further application is embodied in the XDILL tool that supports requirements specification and visual animation of digital logic circuits. Several illustrative SOLVE examples are
Phase 3 randomized trial on larynx preservation comparing sequential vs alternating chemotherapy and radiotherapy.

BACKGROUND Both induction chemotherapy followed by irradiation and concurrent chemotherapy and radiotherapy have been reported as valuable alternatives to total laryngectomy in patients with advanced larynx or hypopharynx cancer. We report results of the randomized phase 3 trial 24954 from the European Organization for Research and Treatment of Cancer. METHODS Patients with resectable advanced squamous cell carcinoma of the larynx (tumor stage T3-T4) or hypopharynx (T2-T4), with regional lymph nodes in the neck staged as N0-N2 and with no metastasis, were randomly assigned to treatment in the sequential (or control) or the alternating (or experimental) arm. In the sequential arm, patients with a 50% or more reduction in primary tumor size after two cycles of cisplatin and 5-fluorouracil received another two cycles, followed by radiotherapy (70 Gy total). In the alternating arm, a total of four cycles of cisplatin and 5-fluorouracil (in weeks 1, 4, 7, and 10) were alternated with radiotherapy with 20 Gy during the three 2-week intervals between chemotherapy cycles (60 Gy total). All nonresponders underwent salvage surgery and postoperative radiotherapy. The Kaplan-Meier method was used to obtain time-to-event data. RESULTS The 450 patients were randomly assigned to treatment (224 to the sequential arm and 226 to the alternating arm). Median follow-up was 6.5 years. Survival with a functional larynx was similar in sequential and alternating arms (hazard ratio of death and/or event = 0.85, 95% confidence interval = 0.68 to 1.06), as were median overall survival (4.4 and 5.1 years, respectively) and median progression-free interval (3.0 and 3.1 years, respectively). Grade 3 or 4 mucositis occurred in 64 (32%) of the 200 patients in the sequential arm who received radiotherapy and in 47 (21%) of the 220 patients in the alternating arm. Late severe edema and/or fibrosis was observed in 32 (16%) patients in the sequential arm and in 25 (11%) in the alternating arm. CONCLUSIONS Larynx preservation, progression-free interval, and overall survival were similar in both arms, as were acute and late toxic effects.
Measuring the flow in lean software development

Responsiveness to customer needs is an important goal in agile and lean software development. One major aspect is to have a continuous and smooth flow that quickly delivers value to the customer. In this paper we apply cumulative flow diagrams to visualize the flow of lean software development. The main contribution is the definition of novel measures connected to the diagrams to achieve the following goals: (1) increase throughput and reduce lead‐time to achieve high responsiveness to customers' needs and (2) to provide a tracking system that shows the progress/status of software product development. An evaluation of the measures in an industrial case study showed that practitioners found them useful and identify improvements based on the measurements, which were in line with lean and agile principles. Furthermore, the practitioners found the measures useful in seeing the progress of development for complex products where many tasks are executed in parallel. The measures are now an integral part of the improvement work at the studied company. Copyright © 2010 John Wiley & Sons, Ltd.
Improved DES algorithm based on irrational numbers

DES (Data Encryption Standard) is a cryptographic standard. However, the applications of it are limited because of the small key space. Based on irrational numbers, an improved scheme that enhances the randomness of sub-Key is proposed, in which the permutation is controlled by irrational number which is considered as false chaos. Moreover, the permutation controlled by data can be performed at high speed in generic CPU. It is shown that this scheme can expand the key space without costing any more time to run.
The Complete Chloroplast Genome Sequence of Podocarpus lambertii: Genome Structure, Evolutionary Aspects, Gene Content and SSR Detection

Background Podocarpus lambertii (Podocarpaceae) is a native conifer from the Brazilian Atlantic Forest Biome, which is considered one of the 25 biodiversity hotspots in the world. The advancement of next-generation sequencing technologies has enabled the rapid acquisition of whole chloroplast (cp) genome sequences at low cost. Several studies have proven the potential of cp genomes as tools to understand enigmatic and basal phylogenetic relationships at different taxonomic levels, as well as further probe the structural and functional evolution of plants. In this work, we present the complete cp genome sequence of P. lambertii. Methodology/Principal Findings The P. lambertii cp genome is 133,734 bp in length, and similar to other sequenced cupressophytes, it lacks one of the large inverted repeat regions (IR). It contains 118 unique genes and one duplicated tRNA (trnN-GUU), which occurs as an inverted repeat sequence. The rps16 gene was not found, which was previously reported for the plastid genome of another Podocarpaceae (Nageia nagi) and Araucariaceae (Agathis dammara). Structurally, P. lambertii shows 4 inversions of a large DNA fragment ∼20,000 bp compared to the Podocarpus totara cp genome. These unexpected characteristics may be attributed to geographical distance and different adaptive needs. The P. lambertii cp genome presents a total of 28 tandem repeats and 156 SSRs, with homo- and dipolymers being the most common and tri-, tetra-, penta-, and hexapolymers occurring with less frequency. Conclusion The complete cp genome sequence of P. lambertii revealed significant structural changes, even in species from the same genus. These results reinforce the apparently loss of rps16 gene in Podocarpaceae cp genome. In addition, several SSRs in the P. lambertii cp genome are likely intraspecific polymorphism sites, which may allow highly sensitive phylogeographic and population structure studies, as well as phylogenetic studies of species of this genus.
An ecient algorithm for nding the M most probable congurations in probabilistic expert systems

A probabilistic expert system provides a graphical representation of a joint probability distribution which enables local computations of probabilities. Dawid (1992) provided a ``ow-propagation' algorithm for nding the most probable connguration of the joint distribution in such a system. This paper analyses that algorithm in detail, and shows how it can be combined with a clever partitioning scheme to formulate an eecient method for nding the M most probable conngurations. The algorithm is a divide and conquer technique, that iteratively identiies the M most probable conngurations. The algorithm has been implemented into the experimental shell XBAIES, which is an extension of BAIES (Cowell, 1992).
Null broadening adaptive beamforming based on semidefinite programming

In this paper, we introduce a procedure for the null broadening algorithm design with respect to the perturbation of the interference location. This method is based on maximizing the array output signal-to-interference-plus-noise-ratio (SINR) subject to quadratic constraints. The design problem can be cast as a fractional quadratically constrained quadratic programming (QCQP) problem that can be solved efficiently using the semidefinite programming (SDP) techniques, the semidefinite relaxation can be used to obtain a lower bound on the optimal objective function. This proposed approach imposes broadened nulls towards the interference region while possesses well-maintained pattern. Theoretical analysis and numerical results demonstrate that the performance of proposed adaptive beamformer is almost always close to optimal.
Predictability of Sri Lankan rainfall based on ENSO

Investigating the year‐round rainfall of Sri Lanka provides understanding into the South Asian monsoon system as it compliments studies on the Indian summer monsoon. The El Niño‐Southern Oscillation (ENSO) is a primary mode of climate variability of this area. Here, the predictability of Sri Lanka rainfall based on ENSO is quantified based on composite analysis, correlations and contingency tables. The rainfall is modestly predictable based on ENSO during January–March, July–August and October–December. El Niño typically leads to wetter conditions during October to December and drier conditions during January to March and July to August on average. The correlations of ENSO indices with rainfall are statistically significant for October to December, January to March and July to August and an analysis based on contingency tables shows modest predictability. The use of ENSO indices derived from the central Pacific sea surfaces improves the predictability from January to June. The predictability in the mountain regions is diminished when garnering orographic rainfall. The predictability in the east is diminished during the cyclone season. The predictability based on ENSO for October to December rainfall is robust on a decadal scale while the predictability of January to March and July to August rainfall has acquired significance in recent decades. An ENSO‐based scheme that is adapted to each season and region, and takes account of decadal variations can thus provide skillful rainfall predictions. Copyright © 2007 Royal Meteorological Society
The TREEhouse: A hybrid model for experiential learning in environmental education

ABSTRACT This article addresses the need to integrate experiential learning into environmental and sustainability curriculum and considers the challenges faced by academic institutions in providing relevant experiential learning opportunities at an appropriate scale. Through an experiential case study, this article illustrates how adopting a “hybrid approach” served to expand traditional perception and infrastructure at Dalhousie University, Faculty of Agriculture, while affording graduate students a space for developing knowledge through the experience of doing. This article discusses the barriers and presents the methodology used to achieve a paradigm shift. This overcomes traditional approaches and could be duplicated for infrastructure transformation into active laboratories for the provision of experiential learning tools for environmental education programs.
Ist die Therapiebeziehung eine Bindungsbeziehung?

Treffen Therapeut und Patient aufeinander und entschließen sich zur Zusammenarbeit, so bringen beide Seiten ihre persönlichen Bindungsmuster mit. Welche Auswirkungen hat dies auf die Arbeitsbeziehung und den Therapieprozess, und wo liegen Chancen und Risiken? Auf der Basis von Überlegungen und Forschungsergebnissen können Rückschlüsse für die therapeutische Praxis gezogen werden.
Places: adding message-passing parallelism to racket

Places bring new support for message-passing parallelism to Racket. This paper gives an overview of the programming model and how we had to modify our existing, sequential runtime-system to support places. We show that the freedom to design the programming model helped us to make the implementation tractable; specifically, we avoided the conventional pain of adding just the right amount of locking to a big, legacy runtime system. The paper presents an evaluation of the design that includes both a real-world application and standard parallel benchmarks.
The SMN Complex Is Associated with snRNPs throughout Their Cytoplasmic Assembly Pathway

ABSTRACT The common neurodegenerative disease spinal muscular atrophy is caused by reduced levels of the survival of motor neurons (SMN) protein. SMN associates with several proteins (Gemin2 to Gemin6) to form a large complex which is found both in the cytoplasm and in the nucleus. The SMN complex functions in the assembly and metabolism of several RNPs, including spliceosomal snRNPs. The snRNP core assembly takes place in the cytoplasm from Sm proteins and newly exported snRNAs. Here, we identify three distinct cytoplasmic SMN complexes, each representing a defined intermediate in the snRNP biogenesis pathway. We show that the SMN complex associates with newly exported snRNAs containing the nonphosphorylated form of the snRNA export factor PHAX. The second SMN complex identified contains assembled Sm cores and m3G-capped snRNAs. Finally, the SMN complex is associated with a preimport complex containing m3G-capped snRNP cores bound to the snRNP nuclear import mediator snurportin1. Thus, the SMN complex is associated with snRNPs during the entire process of their biogenesis in the cytoplasm and may have multiple functions throughout this process.
Performance Analysis of Scheduling in Decode-and-Forward Broadcast Channel with Limited-Feedback

In wireless dual-hop decode-and-forward (DF) relaying networks, multiple relay stations (RS) and users construct a DF broadcast channel (DFBC). Due to unpredictable decoding failure, scheduling in the DFBC should depend on not only channel qualities but also the availability of error-free data at individual RSs. Based on the reception qualities of RSs and channel quality information (CQI), we propose a new centralized scheduling scheme to maximize the sum rate of the DFBC. An exact closed-form expression for the sum rate is derived to analyze the new scheme. To further facilitate the analysis, the bounds of the sum rate are derived as a computationally effective alternative to the exact expression. Simulations demonstrate that the derived closed-form expression quantifies the proposed scheduling method accurately. It is also revealed that the analytical bounds are able to characterize the performance of the new scheduling method with acceptable accuracy.