Miracle-dz/UniFAR-FTUs huggingface dataset:
Disclosure of the genetic risk of Alzheimer's disease.

0.1 (−1.5 to 1.7) 0.91 0.9 (−0.7 to 2.5) 0.27 0.2 (−1.2 to 1.6) 0.79 At 6 mo 0.3 (−1.1 to 1.7) 0.69 0.3 (−1.1 to 1.7) 0.69 −0.4 (−1.8 to 1) 0.56 At 12 mo −0.1 (−1.5 to 1.3) 0.88 0.1 (−1.3 to 1.5) 0.9 −0.1 (−1.5 to 1.3) 0.88 CES-D score‡ At 6 wk 3.1 (0.9 to 5.2) 0.01 2.8 (0.6 to 4.9) 0.01 2.3 (0.3 to 4.3) 0.03
Characterization of Monomeric Intermediates during VSV Glycoprotein Structural Transition

Entry of enveloped viruses requires fusion of viral and cellular membranes, driven by conformational changes of viral glycoproteins. Crystal structures provide static pictures of pre- and post-fusion conformations of these proteins but the transition pathway remains elusive. Here, using several biophysical techniques, including analytical ultracentrifugation, circular dichroïsm, electron microscopy and small angle X-ray scattering, we have characterized the low-pH-induced fusogenic structural transition of a soluble form of vesicular stomatitis virus (VSV) glycoprotein G ectodomain (Gth, aa residues 1–422, the fragment that was previously crystallized). While the post-fusion trimer is the major species detected at low pH, the pre-fusion trimer is not detected in solution. Rather, at high pH, Gth is a flexible monomer that explores a large conformational space. The monomeric population exhibits a marked pH-dependence and adopts more elongated conformations when pH decreases. Furthermore, large relative movements of domains are detected in absence of significant secondary structure modification. Solution studies are complemented by electron micrographs of negatively stained viral particles in which monomeric ectodomains of G are observed at the viral surface at both pH 7.5 and pH 6.7. We propose that the monomers are intermediates during the conformational change and thus that VSV G trimers dissociate at the viral surface during the structural transition.
Deterministically Executing Concurrent Programs for Testing and Debugging

Non-determinism is a serious problem in the testing and debugging of concurrent programs. Thread interleavings may be different on each run, changing the order of events. Testing a concurrent program requires many of these orders to be run, either to determine that all orders produce correct results or to identify the presence of timing-dependent errors called race conditions. This paper presents preliminary work in deterministically executing a concurrent program using a combination of an intermediate compiler form and aspect-oriented programming. Specifically, we execute the code generated for the intermediate compiler form using aspects to control the value returned for the read of any shared variable. This allows us to deterministically execute specific test cases. This work is preliminary, with many outstanding issues, but we feel the technique shows promise.
The incidence and level of contamination of British fresh sausages and ingredients with salmonellas

SUMMARY A five-tube most probable number (MPN) method, with pre-enrichment and enrichment stages, was used in a study of the incidence of salmonella contamination of British fresh sausages and the ingredients used in their manufacture. All samples were taken from a large factory in the course of routine production. There was an incidence of 65 % contamination of pork (n = 20) and 55% (n = 20) in pork and beef sausages. The incidences of contamination of uncooked ingredients varied from 95 % for mechanically recovered meat (n = 20) to 10 % for another type of meat. Cooked and/or dried ingredients were rarely contaminated with these organisms and, when contamination occurred, coliforms were also important. The numbers of salmonellas isolated ranged from 7–40 for pork sausages, from 8–24 for beef and pork sausages and from 0·8–378 organisms/g for ingredients. The following salmonella serotypes were isolated (ranked in descending order of incidence): S. derby, S. dublin, S. newport, S. stanley, S. typhimurium, S. heidelberg, S. infantis and S. agona.
Gastric Adenocarcinoma Presenting with Gastric Outlet Obstruction in a Child

Gastric carcinoma is extremely rare in children representing only 0.05% of all gastrointestinal malignancies. Here, we report the first pediatric case of gastric cancer presenting with gastric outlet obstruction. Upper endoscopy revealed a markedly thickened antral mucosa occluding the pylorus and a clean base ulcer 1.5 cm × 2 cm at the lesser curvature of the stomach. The narrowed antrum and pylorus underwent balloon dilation, and biopsy from the antrum showed evidence of Helicobacter pylori gastritis. The biopsy taken from the edge of the gastric ulcer demonstrated signet-ring-cell type infiltrate consistent with gastric adenocarcinoma. At laparotomy, there were metastases to the liver, head of pancreas, and mesenteric lymph nodes. Therefore, the gastric carcinoma was deemed unresectable. The patient died few months after initiation of chemotherapy due to advanced malignancy. In conclusion, this case report underscores the possibility of gastric adenocarcinoma occurring in children and presenting with gastric outlet obstruction.
Projection Theorems of Divergences and Likelihood Maximization Methods

Projection theorems of divergences enable us to find reverse projection of a divergence on a specific statistical model as a forward projection of the divergence on a different but rather "simpler" statistical model, which, in turn, results in solving a system of linear equations. Reverse projection of divergences are closely related to various estimation methods such as the maximum likelihood estimation or its variants in robust statistics. We consider projection theorems of three parametric families of divergences that are widely used in robust statistics, namely the R\'enyi divergences (or the Cressie-Reed power divergences), density power divergences, and the relative $\alpha$-entropy (or the logarithmic density power divergences). We explore these projection theorems from the usual likelihood maximization approach and from the principle of sufficiency. In particular, we show the equivalence of solving the estimation problems by the projection theorems of the respective divergences and by directly solving the corresponding estimating equations. We also derive the projection theorem for the density power divergences.
Glycemia and Memory

One of the major functions of brain cells (neurons) is to receive, store, and participate in information retrieval – an important process for the successful daily activities of humans [1-3]. This function of neurons is termed ‘memory’ [1, 4, 5]. The present understanding of memory function is the product of the pioneering work of the German scientist Hermann Ebbinghaus [5]. Research suggests that many factors (both endogenous and exogenous) could affect memory function [6-8]. However, the effect of glucose on memory function remains extremely significant for the following reasons [9-12]. First, glucose is the vital energy substrate for neuronal functions [13, 14]. Second, inadequate level of glucose in the blood has been associ‐ ated with a decrease in memory function [15]. Third, disorders in glucose metabolism have been related to various aspects of memory disorders [8, 16]. Furthermore, metabolic products of glucose in neurons themselves participate in one or more stages of memory formation [17-20]. Notwithstanding the significant accumulation of research data in last decades on the relationship between glycemiа and neuronal functions [11, 12, 21], the mechanisms of how glucose affect memory functions remains entirely not understood. In this chapter, we shall examine the possible mechanisms and processes involved in the glucose regulation of memory function. We shall elaborate on the effect of glucose on the major processes of memory functions, precisely on the formation and retrieval of “neural data” – memory.
Preterm birth and visual development.

Visual impairment, oculomotor abnormalities, and refractive error are prevalent among children with a history of preterm birth. These conditions may result from exposure of the immature visual system to early visual stimulation, from nutritional deficits that occur following the abrupt loss of placental maternal-to-fetal transfer of essential nutrients, and as secondary effects of systemic disease or complications associated with preterm birth. This chapter provides an overview of the structural and functional maturation of the visual system of the healthy preterm infant and of several forms of visual impairment that are prevalent in the low birth weight population.
Differential Requirements for COPI Coats in Formation of Replication Complexes among Three Genera of Picornaviridae

ABSTRACT Picornavirus RNA replication requires the formation of replication complexes (RCs) consisting of virus-induced vesicles associated with viral nonstructural proteins and RNA. Brefeldin A (BFA) has been shown to strongly inhibit RNA replication of poliovirus but not of encephalomyocarditis virus (EMCV). Here, we demonstrate that the replication of parechovirus 1 (ParV1) is partly resistant to BFA, whereas echovirus 11 (EV11) replication is strongly inhibited. Since BFA inhibits COPI-dependent steps in endoplasmic reticulum (ER)-Golgi transport, we tested a hypothesis that different picornaviruses may have differential requirements for COPI in the formation of their RCs. Using immunofluorescence and cryo-immunoelectron microscopy we examined the association of a COPI component, β-COP, with the RCs of EMCV, ParV1, and EV11. EMCV RCs did not contain β-COP. In contrast, β-COP appeared to be specifically distributed to the RCs of EV11. In ParV1-infected cells β-COP was largely dispersed throughout the cytoplasm, with some being present in the RCs. These results suggest that there are differences in the involvement of COPI in the formation of the RCs of various picornaviruses, corresponding to their differential sensitivity to BFA. EMCV RCs are likely to be formed immediately after vesicle budding from the ER, prior to COPI association with membranes. ParV1 RCs are formed from COPI-containing membranes but COPI is unlikely to be directly involved in their formation, whereas formation of EV11 RCs appears to be dependent on COPI association with membranes.
Frequency-Shaped Impedance Control for Safe Human–Robot Interaction in Reference Tracking Application

In the control of industrial robots, both safety and reference tracking performance are required. For safe human-robot interaction, robots should exhibit low mechanical (or controlled) impedance so that they react to the interaction forces in a compliant manner. On the other hand, the reference tracking requires for the robots to reject exogenous disturbances, which results in an increased impedance. In order to achieve these two conflicting objectives, a frequency-shaped impedance control (FSIC) method is proposed in this paper. The proposed method utilizes the two different functionalities of the disturbance observer (DOB): a disturbance estimation function as an observer and a disturbance rejection function as a feedback controller. Namely, the DOB is utilized as an observer at the frequencies where the robots interact with humans, while it is used as a feedback controller (i.e., disturbance rejection controller) at the frequencies where the reference tracking is required. The proposed approach is realized by shaping a filter of the DOB in the frequency domain so that the impedance is manipulated to achieve both the compliant interaction and reference tracking. The compromised reference tracking performance in the frequency range, where the impedance is set low, can also be supplemented by feedforward control. A typical feedback controller and a feedforward controller are designed in addition to the DOB-controlled system as the whole control system to enhance reference tracking performance and the betterment of stability robustness. The proposed method is verified by experimental results in this paper.
Automatic Acquisition of Taxonomies from Text: FCA meets NLP

We present a novel approach to the automatic acquisition of taxonomies or concept hierarchies from domain-specific texts based on Formal Concept Analysis (FCA). Our approach is based on the assumption that verbs pose more or less strong selectional restrictions on their arguments. The conceptual hierarchy is then built on the basis of the inclusion relations between the extensions of the selectional restrictions of all the verbs, while the verbs themselves provide intensional descriptions for each concept. We formalize this idea in terms of FCA and show how our approach can be used to acquire a concept hierarchy for the tourism domain out of texts. We then evaluate our method by considering an already existing ontology for this domain.
3-D Surface Segmentation of Free-Form Objects Using Implicit Algebraic Surfaces

This paper describes a new technique for free-form object segmentation from a single arbitrary-viewed range image. The aim is to derive a surface description of objects that may vary in shape and complexity without any restriction on the type of surfaces on the object. We propose a surface representation scheme that uses edge information to built a surface description using algebraic implicit surfaces. The proposed technique, not only reduces the number of used patches, but also preserves surface-depth and orientation continuity. This is done by propagating and blending piecewise hermite interpolation surfaces. The system has been tested on several synthetic and real range images and the experimental results have shown that the system can produce reliable surface description of a variety of free-form objects.
Front-of-pack nutrition labelling: are multiple formats a problem for consumers?

Background: Nutrition labels are a potentially valuable tool to assist consumers in making healthy food choices. Front-of-pack labels are a relatively new format and are now widely used across many European countries, but it is unclear which of the many formats in use are best understood by consumers. It is also unclear whether the existence of multiple formats impedes understanding and use. This article addresses this question with findings from a study commissioned by the UK Food Standards Agency to provide evidence to inform policy decisions in this area. Methods: In-depth qualitative interviews were used to explore consumers’ decision-making processes when using two different front-of-pack label formats to judge the relative healthiness of a pair of products. Participants were presented with product pairs differently labelled and a series of structured prompts were used to access their internal dialogues and to identify any difficulties encountered. Results: The interviews revealed that making product comparisons using different label formats was challenging for participants and particularly for those product pairs where there was not an obvious answer. When the label formats on the product pairs lacked a common element, such as text, this also caused difficulties and misinterpretation. The comparisons also took time and effort that would be a deterrent in real-life situations. Conclusions: These findings indicate that the existence of multiple front-of-pack label formats in the marketplace may impede consumer comprehension and discourage use. They suggest that a single format may encourage consumers to use front-of-pack labels in making healthy food choices.
Support vector regression method for boundary value problems

This article presents a method to solve boundary value problems using support vector regression and radial basis function network. The boundary is determined by a number of points that belong to it and are closely located, so as to offer a reasonable representation. Two methods are employed: a support vector regression is constructed to have part of effect on the boundary conditions as the basic approximate element and contains adjustable parameters; a radial basis function network is used to account for the exact satisfaction of the boundary conditions. The method was used to solve a two-dimensional partial differential equation and had gained feasible accurate result. This method is completely practical in technology.
Approximate Parametric Dynamic Programming in Inventory Management

We present an approximation method for inventory management under multiple suppliers and stochastic lead times. The method is based on parametric dynamic programming using convex piecewise linear approximations of the differential cost function in approximate relative value iteration steps and works for a range of stochastic control problems with linear dynamics and convex piecewise linear immediate costs. The obtained differential cost approximation not only defines a policy that performs well in practise, it also yields lower bounds that are useful to judge the quality of the corresponding policy or other heuristics. ∗Contact author. Email address: wor@zurich.ibm. com †IBM Research Zurich, Saeumerstrasse 4, CH-8803 Rueschlikon, Switzerland. ‡ETH Zurich, Institute for Operations Research, Raemistrasse 101, CH-8092 Zurich, Switzerland.
Insulin-Like Growth Factor-1 as a Prognostic Marker in Patients with Acute Ischemic Stroke

Objective Insulin-like growth factor-1 (IGF-1) has been associated with cardiovascular risk factors and atherosclerosis. The aim of the present study was to evaluate the prognostic value of IGF-1 levels in patients with acute ischemic stroke (AIS). Methods All patients with first-ever AIS from August 1, 2012 to August 31, 2013 were recruited to participate in the study. Clinical data were collected. The National Institutes of Health Stroke Scale (NIHSS) score was assessed on admission blinded to serum IGF-1 levels. For the assessment of functional outcome at 90 days Modified Rankin Scale (mRS) was used. On admission, serum IGF-1 levels were determined by chemiluminescence immunoassay. The influence of IGF-1 levels on functional outcome and death was assessed by multivariate logistic regression analysis. Results Patients with an unfavorable outcomes and non-survivors had significantly decreased serum IGF-1 levels on admission (P<0.0001 for both). IGF-1 was an independent prognostic marker of functional outcome and death [odds ratio 0.89 (0.84–0.93) and 0.90 (0.84–0.95), respectively, P<0.0001 for both, adjusted for age, NIHSS score and other predictors] in patients with ischemic stroke. Serum IGF-1 levels ≤130 ng/mL was as an value indicator for unfavorable functional outcome (OR 3.31, 95% CI:1.87–5.62; P<0.0001), after adjusting for other significant confounders. Conclusions We reported a significant association between low serum IGF-1 levels and unfavorable functional outcome and death.
Modeling of a radial permanent magnet motor with trapezoidal shaped poles

For years, design of conventional permanent magnet motors has been limited mainly to the variation of the stator winding function and little research has been made on stator pole modification as an alternative for motor design. Soft magnetic composites (SMCs) have opened up new possibilities for the 3-D pole shape design of both DC and AC machines owing to their isotropic properties, while having low conductivity. Here, a PM motor with trapezoidal shaped poles is presented and simulated. A modified trapezoidal-shaped poles is also proposed as further work, to reduce the torque pulsation. The latter theoretically exhibits zero torque pulsations. Some FEA results are also presented
The N276 Glycosylation Site Is Required for HIV-1 Neutralization by the CD4 Binding Site Specific HJ16 Monoclonal Antibody

Immunogen design for HIV-1 vaccines could be based on epitope identification of naturally occurring neutralizing antibodies in infected patients. A tier 2 neutralizing monoclonal antibody (mAb), HJ16 recognizes a new epitope in the CD4 binding site (CD4bs) region that only partially overlaps with the b12 epitope. We aimed to identify the critical binding site by resistance induction in a sensitive primary CRF02_AG strain. In four independent dose-escalation studies, the N276D mutation was consistently the only alteration found and it was confirmed to be responsible for resistance to HJ16 by site-directed mutagenesis in envelopes (envs) of the homologous CRF02_AG, as well as of a subtype A and a subtype C primary isolate. This mutation removes an N-linked glycosylation site. The effect of N276D was very selective, as it failed to confer resistance to a range of other entry inhibitors. Remarkably, sensitivity to the CD4bs VRC01 and VRC03 mAbs was increased in the N276D mutated viruses. These data indicate that binding of the CD4bs specific HJ16 mAb critically depends on the interaction with the N276-glycan, thus indicating that HJ16 is the first glycan dependent CD4bs-specific mAb.
Historical Perspectives and the Interpretation of Unemployment

JN THE LAST DECADE, the levels of unemployment in industrialized countries have risen dramatically. Rates now are typically two, and in some cases, three and four times those prevailing in the 1950s and 1960s. The fact that these new higher levels are widely tolerated suggests that our thinking about the meaning and significance of unemployment has changed enormously over the period. Such a change is certainly present in the thinking among professional economists. In the 1960s the standard view was that the unemployed represented unutilized resources; their existence in an economy where the vast majority of people had unsatisifed wants was seen as a major social paradox and the most important unsolved intellectual puzzle of the capitalist economic system. This fed the rationale for Keynesian countercyclical fiscal policy and government deficit spending: The government could reasonably print money in order to hire the unemployed because the resources absorbed in the process were essentially "free goods. " Today, a good number of professional economists, certainly in the United States but to a lesser extent throughout the world, have come to view measured unemployment in industrial economies as an artifact in at least three senses. It is a statistical artifact of a measurement process that classifies as unemployed people who are not really available for work. It is an institutional artifact of a system of social insurance and public welfare that encourages an extension of the process of job search. And it is an artifact of the language that uses a term which in everyday parlance means forced idleness for activities that have important productive functions akin to the functions of inventories, information processing, and investment associated with the utilization of capital goods. These interpretations to be sure hardly constitute a consensus about the meaning of unemployment. But they are no more diverse than the range of views that underlay the older orthodoxy. And for policy makers and economic researchers, they carry a single message: There are many more serious problems toward which to direct attention. These new views about unemployment were developed out of a set of ideas originally associated with the Chicago School of economics, where the emphasis-at once positive and normative-was placed on the competitive market as the gover* A Review of Alexander Keyssar, Out of Work: The First Century of Unemployment in Massachusetts. Cambridge: Cambridge University Press, 1986 and Robert Salais, Nicolas Baverez, and B6nedicte Reynaud, L'invention du chomage: Histoire et transformations d'une categorie en France des annees 1890 aux annees 1980. Paris: Presses Universitaires de France, 1986.