Miracle-dz/UniFAR-FTUs huggingface dataset:
Nickel abundance in stony cosmic spherules: Constraining precursor material and formation mechanisms

Abstract– We report bulk and olivine compositions in 66 stony cosmic spherules (Na2O < 0.76 wt%), 200–800 μm in size, from the Transantarctic Mountains, Antarctica. In porphyritic cosmic spherules, relict olivines that survived atmospheric entry heating are always Ni‐poor and similar in composition to the olivines in carbonaceous or unequilibrated ordinary chondrites (18 spherules), and equilibrated ordinary chondrites (one spherule). This is consistent with selective survival of high temperature, Mg‐rich olivines during atmospheric entry. Olivines that crystallized from the melts produced during atmospheric entry have NiO contents that increase with increasing NiO in the bulk spherule, and that range from values similar to those observed in chondritic olivines (NiO generally <0.5 wt%) to values characteristic of olivines in meteoritic ablation spheres (NiO > 2 wt%). Thus, NiO content in olivine cannot be used alone to distinguish meteoritic ablation spheres from cosmic spherules, and the volatile element contents have to be considered. We propose that the variation in NiO contents in cosmic spherules and their olivines is the result of variable content of Fe, Ni metal in the precursor. NiO contents in olivines and in cosmic spherules can thus be used to discuss their parent body. Ni‐poor spherules can be derived from C‐rich and/or metal‐poor precursors, either related to CM, CI, CR chondrites or to chondritic fragments dominated by silicates, regardless of the parent body. Ni‐rich spherules (NiO > 0.7 wt%) that represent 55% of the 47 barred‐olivine spherules we studied, were derived from the melting of C‐poor, metal‐rich precursors, compatible with ordinary chondrite or CO, CV, CK carbonaceous chondrite parentages.
Identification and Quantification of 2 (cid:1) ,3 (cid:1) -cAMP Release by the Kidney

We recently developed a sensitive assay for 3 (cid:1) ,5 (cid:1) -cAMP using high-performance liquid chromatography-tandem mass spec- trometry. Using this assay, we investigated the release of 3 (cid:1) ,5 (cid:1) cAMP from isolated, perfused rat kidneys. To our surprise, we observed a dominant chromatographic peak that was because of an endogenous substance that had the same parent ion as 3 (cid:1) ,5 (cid:1) -cAMP and that fragmented to the same daughter ion (adenine) as 3 (cid:1) ,5 (cid:1) -cAMP. However, the retention time of this unknown was approximately 2.9 min, compared with 6.3 min for authentic 3 (cid:1) ,5 (cid:1) -cAMP. We hypothesized that the unknown substance was an isomer of 3 (cid:1) ,5 (cid:1) -cAMP. The unknown substance had the same retention time and mass spectral proper- ties as authentic 2 (cid:1) ,3 (cid:1) -cAMP. Renal venous secretion of 2 (cid:1) ,3 (cid:1) cAMP was greater in kidneys from 20-week-old genetically hypertensive rats compared with age-matched normotensive rats (12.49 versus 5.32 (cid:2) 1.97 kidney weight, respectively; n 18). Isoproterenol (1 (cid:1) M; (cid:2) -adrenoceptor agonist) increased renal venous
Racial Differences in Body-Mass Indices for Men Imprisoned in 19th Century US Prisons: A Multinomial Approach

Little research has been done on the body mass index values of 19th century US African-Americans and whites. This paper uses 19th century US prison records to demonstrate that although modern BMIs have increased in the 20th century, 19th century black and white BMIs were distributed symmetrically; neither underweight nor obese individuals were common. Throughout the 19th century, black and white BMI values declined. Farmers were consistently heavier than non-farmers, and blacks in Upper South had lower BMI values than their counterparts in other US regions.
Sm—Nd isotopic age of Precambrian—Cambrian boundary in China

Abstract By the new method of Sm—Nd isotopic dating on phosphatic small skeletal fossils and collo-phanite minerals, the Zhongyicun Member of the earliest Cambrian Meishucun Stage at Meishucun in Yunnan, southern China, has been dated at 562.8 ± 7.9 Ma and 562.1 ± 5.7 Ma. Another Sm—Nd age, 570.3 ± 17.1 Ma, has been obtained with samples from the Zhongyicun Member in Yunnan and its stratigraphic equivalents in Sichuan and Xinjiang. These data tend to suggest that the best age estimate of the Precambrian—Cambrian boundary is very likely within the range of 560–570 Ma. As biophosphates and sedimentary phosphates are widely distributed in sequences of the Precambrian—Cambrian transition, the Sm-Nd isotopic method is recommended as an effective approach for precise dating of the initial Cambrian boundary.
Clinical Burkholderia pseudomallei isolates from north Queensland carry diverse bimABm genes that are associated with central nervous system disease and are phylogenomically distinct from other Australian strains

Background Burkholderia pseudomallei is an environmental gram-negative bacterium that causes the disease melioidosis and is endemic in many countries of the Asia-Pacific region. In Australia, the mortality rate remains high at approximately 10%, despite curative antibiotic treatment being available. The bacterium is almost exclusively found in the endemic region, which spans the tropical Northern Territory and North Queensland, with clusters occasionally present in more temperate climates. Despite being endemic to North Queensland, these infections remain understudied compared to those of the Northern Territory. Methodology/Principal findings This study aimed to assess the prevalence of central nervous system (CNS) disease associated variant bimABm, identify circulating antimicrobial resistance mutations and genetically distinct strains from Queensland, via comparative genomics. From 76 clinical isolates, we identified the bimABm variant in 20 (26.3%) isolates and in 9 (45%) of the isolates with documented CNS infection (n = 18). Explorative analysis suggests a significant association between isolates carrying the bimABm variant and CNS disease (OR 2.8, 95% CI 1.3–6.0, P = 0.009) compared with isolates carrying the wildtype bimABp. Furthermore, 50% of isolates were identified as novel multi-locus sequence types, while the bimABm variant was more commonly identified in isolates with novel sequence types, compared to those with previously described. Additionally, mutations associated with acquired antimicrobial resistance were only identified in 14.5% of all genomes. Conclusions/Significance The findings of this research have provided clinically relevant genomic data of B. pseudomallei in Queensland and suggest that the bimABm variant may enable risk stratification for the development CNS complications and be a potential therapeutic target.
Simulation-Based Team Leadership Training Improves Team Leadership During Actual Trauma Resuscitations: A Randomized Controlled Trial

domized and 360 resuscitations were analyzed. DOI: 10.1097/CCM.0000000000004077 1Center for Experiential Learning and Simulation, Department of Emergency Medicine, University of Florida College of Medicine, Gainesville, FL. 2Department of Emergency Medicine, University of Florida College of Medicine – Jacksonville, Jacksonville, FL. 3Department of Emergency Medicine, University of Washington, Seattle, WA. 4Department of Psychology, Michigan State University, East Lansing, MI. 5Department of Emergency Medicine, Office of Educational Affairs, University of Florida College of Medicine – Jacksonville, Jacksonville, FL. 6Department of Surgery, University of Washington, Seattle, WA. 7Department of Medicine, University of Washington, Seattle, WA. 8Department of Psychology, University of Maryland, College Park, MD. 9Department of Management, Michigan State University, East Lansing, MI.
Metabolomic analysis of extreme freezing tolerance in Siberian spruce ( Picea obovata )

nitrogen. the biochemical and biophysical strategies of ELT survival. (cid:1) We proﬁled needle metabolites using gas chromatography coupled with mass spectrometry (GC-MS) to explore the metabolic changes that occur during cold acclimation caused by natural temperature ﬂuctuations. (cid:1) In total, 223 metabolites accumulated and 52 were depleted in fully acclimated needles compared with pre-acclimation needles. The metabolite proﬁles were found to develop in four distinct phases, which are referred to as pre-acclimation, early acclimation, late acclimation and fully acclimated. Metabolite changes associated with carbohydrate and lipid metabolism were observed, including changes associated with increased rafﬁnose family oligosaccharide synthesis and accumulation, accumulation of sugar acids and sugar alcohols, desaturation of fatty acids, and accumulation of digalactosylglycerol. We also observed the accumulation of protein and nonprotein amino acids and polyamines that may act as compatible solutes or cryoprotectants. (cid:1) These results provide new insight into the mechanisms of freezing tolerance development at the metabolite level and highlight their importance in rapid acclimation to ELT in P. obovata .
Extracting Urban Road Networks from High-resolution True Orthoimage and Lidar

Automated or semi-automated feature extraction from remotely collected, large scale image data has been a challenging issue in digital photogrammetry for many years. In the feature extraction field, fusing different types of data to provide complementary information about the objects is becoming increasingly important. In this paper, we present a newly developed approach for the automatic extraction of urban area road networks from a true orthoimage and lidar assuming the road network to be a semi-grid pattern. The proposed approach starts from the subdivision of a study area into small regions based on homogeneity of the dominant road directions from the true orthoimage. Each region’s road candidates are selected with a proposed free passage measure. This process is called the “acupuncture” method. Features around the road candidates are used as key factors for an advanced “acupuncture method” called the region-based acupuncture method. Extracted road candidates are edited to avoid collocation with non-road features such as buildings and grass fields. In order to produce a building map for the prior step, a first-last return analysis and morphological filter are used with the lidar point cloud. A grass area thematic map is generated by supervised classification techniques from a synthetic image, which contains the three color bands from the true orthoimage and the lidar intensity value. Those non-road feature maps are used as a blocking mask for the roads. The accuracy of the result is evaluated quantitatively with respect to manually compiled road vectors, and a completeness of 80 percent and a correctness of 79 percent are obtained with the proposed algorithm on an area of 1,081,600 square meters.
Associations between Religiosity and Perinatal Anxiety Symptoms among Women of Mexican Descent

Anxiety is an important mental health disorder during pregnancy as over half of pregnant women experience anxiety symptoms (Meades & Ayers 2011). Latinas, mainly of Mexican descent, report some of the highest levels of anxiety symptoms (20–36%) (Lara-Cinisomo, Fujimoto, Oksas, Jian, & Gharheeb 2019) compared to the general population (15–17%) (Fairbrother, Janssen, Antony, Tucker, & Young 2016). This is particularly problematic as perinatal anxiety is associated with a host of adverse maternal, birth, and infant outcomes (Davis et al. 2004; Leis, Heron, Stuart, & Mendelson 2014; O’Connor, Heron, Golding, Glover, & the 2003; Tomfohr-Madsen et al. 2019). Thus, identification of culturally relevant factors to buffer against anxiety symptoms are needed. A recent review identified religiosity, an important value of Mexican culture, as a protective factor against postpartum depression (Lara-Cinisomo, Wood, & Fujimoto 2019), but the role of religion as a protective factor in perinatal anxiety is not known.
Symptoms, unmet needs, psychological well-being and health status in prostate cancer survivors

Citation for published version: Watson, E, Shinkins, B, Frith, E, Neal, D, Hamdy, F, Walter, F, Weller, D, Wilkinson, C, Faithfull, S, Wolstenholme, J, Sooriakumaran, P, Kastner, C, Campbell, C, Neal, R, Butcher, H, Matthews, M, Perera, R & Rose, P 2015, 'Symptoms, unmet needs, psychological well-being and health status in prostate cancer survivors: implications for redesigning follow-up' BJU International. DOI: 10.1111/bju.13122
History of Mechanical Circulatory Support Devices

History of Mechanical Circulatory Support Devices Advanced heart failure (HF) is a major cause of morbidity and mortality in the United States, and heart transplantation remains as the gold standard therapy. Because of scarcity of donor organs, the application of mechanical circulatory support devices has become a crucial approach in HF therapy as a bridge to transplantation. Therefore, mechanical circulatory support devices have existed both conceptually and experimentally for >40 years, along which an exponential evolution of mechanical circulatory support device technology has occurred. To mimic human physiology, the first generation of left ventricular assist devices (LVADs) were pulsatile volume displacement pumps (HeartMate XVE LVAS, Thoratec PVAD, and Novacor, etc). Insights demonstrating the inessentiality of the pulsatile nature of LVADs for survival from a physiological standpoint propelled the design of second-generation continuous flow devices (HeartMate II [Thoratec Inc], the Micromed DeBakey VAD, Berlin Heart Incor [Berlin Heart AG], and the Jarvik 2000 [Jarvik Heart Inc]), which emerged with superior safety and durability. Consequently, the HeartMate II was approved for bridge to transplantation and destination therapy in the United States. Recent reports have demonstrated a 2-year survival rate of 87% in destination therapy patients under intense surveillance, comparable with open heart transplantation survival statistics. In parallel, these promising outcomes of LVADs in HF therapy have spawned the translational research field of LV reverse remodeling, which has already shown great promise for elucidating underlying molecular and cellular mechanisms.
Impact of Digital Educational Interventions to Support Parents Caring for Acutely Ill Children at Home and Factors That Affect Their Use: Protocol for a Systematic Review

Background: Urgent and emergency care health services are overburdened, and the use of these services by acutely ill infants and children is increasing. A large proportion of these visits could be sufficiently addressed by other health care professionals. Uncertainty about the severity of a child’s symptoms is one of many factors that play a role in parents’ decisions to take their children to emergency services, demonstrating the need for improved support for health literacy. Digital interventions are a potential tool to improve parents’knowledge, confidence, and self-efficacy at managing acute childhood illness. However, existing systematic reviews related to this topic need to be updated and expanded to provide a contemporary review of the impact, usability, and limitations of these solutions. JMIR Res Protoc 2021 | vol. 10 | iss. 6 | e27504 | p. 1 https://www.researchprotocols. org/2021/6/e27504 (page number not for citation purposes) Milne-Ives et al JMIR RESEARCH PROTOCOLS
Rotation and offset of the Gondwana convergent margin in the New Zealand region following Cretaceous jamming of Hikurangi Plateau large igneous province subduction

Jamming of the Hikurangi Plateau (large igneous province) subduction, within the Chatham Rise convergent margin of Gondwana at circa 105 Ma, led to offset and rotation of the convergent margin before subduction ceased in the New Zealand region at circa 100 Ma. The southern limit of the plateau, following leading slab break off, is highlighted by a lineament of prominent horst blocks in the southern Bounty Trough. Subduction jamming of the Gondwana margin, and accompanying compression of the onshore margin and/or extension of the offshore margin, has led to two 60 km left‐lateral SSE offsets of the Chatham Rise convergent margin at the coast and in inland Canterbury. Recognition of the onshore Chatham Rise using the gravity data also highlights the correlation of the inland Chatham Rise and central South Island seismicity. In a similar manner to the rotation of Cretaceous spreading‐ridge and transform‐fault fabric adjacent to the Osbourn Trough spreading ridge, the convergence direction at the Gondwana margin was rotated anticlockwise to N‐S between 105 and 100 Ma. Most of this rotation has been accommodated by offshore extension and margin offset. The divergence between the anticlockwise rotation of offshore crustal structure and the jammed onshore margin led to the development of the Great South Basin at 105–100 Ma. Further offshore in the Bounty Trough, extensional zones, formed between crustal blocks rotated to adjust to a changed Cretaceous direction of subduction, are evident in gravity and seismic profiles.
(2019). The Relationship Between Ambient Atmospheric Fine Particulate Matter (PM2.5) and Glaucoma in a Large Community Cohort. Investigative Ophthalmology and

ambient atmospheric ﬁne particulate matter (PM 2.5 ) and glaucoma in a large community cohort. P URPOSE . Glaucoma is more common in urban populations than in others. Ninety percent of the world’s population are exposed to air pollution above World Health Organization (WHO) recommended limits. Few studies have examined the association between air pollution and glaucoma. Questionnaire data, ophthalmic measures, and ambient residential area air quality data for 111,370 UK Biobank participants were analyzed. Particulate matter with an aerodynamic diameter < 2.5 l m (PM 2.5 ) was selected as the air quality exposure of interest. Eye measures included self-reported glaucoma, intraocular pressure (IOP), and average thickness of macular ganglion cell–inner plexiform layer (GCIPL) across nine Early Treatment Diabetic Retinopathy Study (ETDRS) retinal subﬁelds as obtained from spectral-domain optical coherence tomography. We examined the associations of PM 2.5 concentration with self- reported glaucoma, IOP, and GCIPL. R ESULTS . Participants resident in areas with higher PM 2.5 concentration were more likely to report a diagnosis of glaucoma (odds ratio ¼ 1.06, 95% conﬁdence interval [CI] ¼ 1.01–1.12, per interquartile range [IQR] increase P ¼ 0.02). Higher PM 2.5 concentration was also associated with thinner GCIPL ( b ¼ (cid:2) 0.56 l m, 95% CI ¼ (cid:2) 0.63 to (cid:2) 0.49, per IQR increase, P ¼ 1.2 3 10 (cid:2) 53 ). A dose–response relationship was observed between higher levels of PM 2.5 and thinner GCIPL ( P < 0.001). There was no clinically relevant relationship between PM 2.5 concentration and IOP. C ONCLUSIONS . Greater exposure to PM 2.5 is associated with both self-reported glaucoma and adverse structural characteristics of the disease. The absence of an association between PM 2.5 and IOP suggests the relationship may occur through a non–pressure-dependent mechanism, possibly neurotoxic and/or vascular effects. microparticulate air pollutants,
The exchange of acetaldehyde between plants and the atmosphere: Stable carbon isotope and flux measurements

Stony Brook University Libraries. SBU Graduate School in Marine and Atmospheric Sciences. Lawrence Martin (Dean of Graduate School), John E. Mak - Dissertation Advisor Associate Professor, Institute for Terrestrial and Planetary Atmospheres/ Marine Sciences Research Center, Stony Brook University, Manuel Lerdau – Chairperson of Defense Professor, Department of Ecology and Evolution with courtesy appointment in Marine Sciences, Stony Brook University, Nicole Riemer Assistant Professor, Institute for Terrestrial and Planetary Atmospheres/ Marine Sciences Research Center, Stony Brook University, Alex Guenther Senior Scientist, Section Head and Group Leader Biosphere-Atmosphere Interactions Group Atmospheric Chemistry Division National Center for Atmospheric Research.
Reality of care for musculoskeletal diseases at the population level Results of the PROCLAIR collaborative project

Background. The objective of the research consortium PROCLAIR was to gain population level knowledge on the treatment of patientswith rheumatoid arthritis (RA), axial spondylarthritis (axSpA) and osteoarthritis (OA) in Germany. Aims. A main question of the consortium was whether it is possible to identify groups of people who were exposed to a particular risk of undersupply or oversupply of treatment.In addition, the study investigatedthe validityof claims data for these diseases as a basis for further studies. Patients and methods. Cross-sectional surveys were carried out among insurees of the BARMER statutoryhealth insurance fund whose claimsdata included RA, axSpA and OA diagnoses.The questionnairedatawere linked with the claims data of the insured persons if they agreed. Results. In all three diseases risk groups for care deﬁcits could be identiﬁed. Persons with RA who are not treated by a specialist have less access to drug treatment. Physical therapyis prescribed for all three diagnoses at a low level, even for people undergoing joint replacementsurgery. A connection between depressive symptoms and disease activity or function in axSpA was shown. In addition to the results relevant to care, the PROCLAIR network has also made contributions to criticallyassessthe qualityof health insurance data. Discussion. The combination of billing data with survey data enables a comprehensive description of the treatment of musculoske- letal diseases. Particularly relevant factors are the specialization of the physician, sociodemographic parametersof the patients and the region of residence. In particular, accessto treatmentcannot be investigatedin randomized clinicaltrials.
A Randomized Phase II Trial of Epigenetic Priming with Guadecitabine and Carboplatin in Platinum-resistant, Recurrent Ovarian Cancer

PURPOSE: Platinum resistance in ovarian cancer (OC) is associated with epigenetic modifications. Hypomethylating agents (HMAs) have been studied as carboplatin re-sensitizing agents in OC. This randomized phase 2 trial compared guadecitabine, a second generation HMA, and carboplatin (G+C) against second-line chemotherapy in women with measurable or detectable platinum-resistant OC. PATIENTS AND METHODS: Patients received either G+C (guadecitabine 30 mg/m2 SC oncedaily for 5 days and carboplatin) or treatment of choice (TC; topotecan, pegylated liposomal doxorubicin, paclitaxel, or gemcitabine) in 28-day cycles until progression or unacceptable toxicity. The primary endpoint was progression-free survival (PFS); secondary endpoints were RECIST v1.1 and CA-125 response rate, 6-month PFS, and overall survival (OS). RESULTS: Of 100 patients treated, 51 received G+C and 49 received TC, of which 27 crossed over to G+C. The study did not meet its primary endpoint as the median PFS was not statistically different between arms (16.3 weeks vs 9.1 weeks in the G+C and TC groups, respectively; P = 0.07). However, the 6-month PFS rate was significantly higher in the G+C group (37% vs. 11% in TC group; P = 0.003). The incidence of grade 3 or higher toxicity was similar in G+C and TC groups (51% and 49%, respectively), with neutropenia and leukopenia being more frequent in the G+C group. CONCLUSIONS: Although this trial did not show superiority for PFS of G+C versus TC, the 6month PFS increased in G+C treated patients. Further refinement of this strategy should focus on identification of predictive markers for patient selection.
University of Southern Denmark A population-based, incidence cohort study of mid-back pain after traffic collisions

• You may download this work for personal use only. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying this open access version If you believe that this document breaches copyright please contact us providing details and we will investigate your claim. Please direct all enquiries to puresupport@bib.sdu. dk