Miracle-dz/UniFAR-FTUs huggingface dataset:
Headscarf Politics in Turkey: A Postcolonial Reading (review)

the women wearing them, or for allowing women from conservative circles to enter the public space and acquire instruments of empowerment such as education, employment, and socialization. The rise of political Islam since the late 1970s, which involved both state-mandated dress codes (e.g., Iran, Afghanistan, Saudi Arabia) and a spread of notions about “proper Islamic attires” led “covered women” to increase in number and become more visible on the streets of Muslim-majority states or countries with sizeable immigrant Muslim populations. The fact that many of these women are highly educated or brought up in “secular households” has challenged the assumptions about “concealing” being a marker of traditionalism, ignorance, or subjugation. Thus, the literature on the conditions and concealing of Muslim women — including the predicament of women who assume “concealing” as a requirement of their religion but face public harassment, exclusion, and state-imposed bans, as in the cases of France and Turkey — has proliferated during the last two decades. What would distinguish Headscarf Politics in Turkey from the other writings on the subject is its author’s background. Merve Kavakci Islam is not only a social scientist but also a “covered Muslim woman” who personally suffered the consequences of the state policy and institutional regulations that ban the wearing of headscarves by public employees, school teachers, and students. The relatively quietly pursued policy became a controversial issue in the 1980s, when the military government issued a regulation that intended to forcefully implement the ban for civil servants and the Council of Higher Education, which it established to depoliticize and regulate universities, barred female students with headscarves from attending classes and taking exams. Students resisted the ban in various ways, including hunger strikes and street protests, and faced violent repression by the police and military forces. Some compromised by removing their headscarf on university premises, wearing a hat over the headscarf, or putting on a wig. Others gave up their education, but those who had the means and family support left the country to pursue their higher education abroad. uses the perspectives drawn from the social movement literature judiciously to provide a systematic and interesting analysis of the political transformation that has been taking place in Turkey in recent years. The Mobilization of Islam in Turkey offers a detailed, informative, and balanced explanation of how the Islamist movement, which began from a marginal position in Turkish politics, eventually grew to occupy a central role, providing the organizational basis and leadership for one of the most successful parties in the Turkey’s modern political history.
On the Constants in Some Inverse Inequalities for Nite Element Functions

We determine the constants in some inverse inequalities for nite element functions. These constants are crucial for the correct calibration of a posteriori error estimators. R esum e: Pour des el ements nis on calcule les constantes dans certaines in egalit es inverses. Cettes constantes sont importantes pour l' etalonnage des estimateurs d'erreur a posteriori.
ChrR positively regulates transcription of the Rhodobacter sphaeroides cytochrome c2 gene

Transcription of the Rhodobacter sphaeroides cytochrome c2 gene (cycA) is negatively regulated by both the presence of oxygen and intermediates in tetrapyrrole biosynthesis. A mutation responsible for uncoupling cycA transcription from tetrapyrrole availability was localized to a gene (chrR) that encodes a 357-amino-acid protein. Analysis of a defined chrR null mutation indicated that this protein positively regulated cycA transcription. From this and other results, it appeared that the positive action of ChrR on cycA transcription is blocked by altering the availability of either heme or some intermediate in tetrapyrrole biosynthesis. A single missense mutation which substitutes an Arg for a Cys at residue 182 of ChrR (C182R) was shown to be necessary and sufficient for the increased cycA transcription seen in the mutant strain Chr4. Thus, it appears that this C182R substitution generated an altered-function form of ChrR. In addition, by analyzing cycA transcription in delta ChrR strains, we showed that ChrR was not required for increased cycA transcription under anaerobic conditions. Instead, our results indicated that ChrR and the response regulator PrrA (J. M. Eraso and S. Kaplan, J. Bacteriol. 176:32-43, 1994) functioned independently at the upstream cycA promoter that is activated under anaerobic conditions.
Statistical models for RNA-seq data derived from a two-condition 48-replicate experiment

Motivation: High-throughput RNA sequencing (RNA-seq) is now the standard method to determine differential gene expression. Identifying differentially expressed genes crucially depends on estimates of read-count variability. These estimates are typically based on statistical models such as the negative binomial distribution, which is employed by the tools edgeR, DESeq and cuffdiff. Until now, the validity of these models has usually been tested on either low-replicate RNA-seq data or simulations. Results: A 48-replicate RNA-seq experiment in yeast was performed and data tested against theoretical models. The observed gene read counts were consistent with both log-normal and negative binomial distributions, while the mean-variance relation followed the line of constant dispersion parameter of ∼0.01. The high-replicate data also allowed for strict quality control and screening of ‘bad’ replicates, which can drastically affect the gene read-count distribution. Availability and implementation: RNA-seq data have been submitted to ENA archive with project ID PRJEB5348. Contact: g.j.barton@dundee.ac. uk
Causation of Severe and Fatal Accidents in the Manufacturing Sector

The main purpose of this paper is to identify the most frequent causes of accidents in the manufacturing sector in Andalusia, Spain, to help safety practitioners in the task of prioritizing preventive actions. Official accident investigation reports are analyzed. A causation pattern is identified with the proportion of causes of each of the different possible groups of causes. We found evidence of a differential causation between slight and non-slight accidents. We have also found significant differences in accident causation depending on the mechanism of the accident. These results can be used to prioritize preventive actions to combat the most likely causes of each accident mechanism. We have also done research on the associations of certain latent causes with specific active (immediate) causes. These relationships show how organizational and safety management can contribute to the prevention of active failures.
iSubgraph: Integrative Genomics for Subgroup Discovery in Hepatocellular Carcinoma Using Graph Mining and Mixture Models

The high tumor heterogeneity makes it very challenging to identify key tumorigenic pathways as therapeutic targets. The integration of multiple omics data is a promising approach to identify driving regulatory networks in patient subgroups. Here, we propose a novel conceptual framework to discover patterns of miRNA-gene networks, observed frequently up- or down-regulated in a group of patients and to use such networks for patient stratification in hepatocellular carcinoma (HCC). We developed an integrative subgraph mining approach, called iSubgraph, and identified altered regulatory networks frequently observed in HCC patients. The miRNA and gene expression profiles were jointly analyzed in a graph structure. We defined a method to transform microarray data into graph representation that encodes miRNA and gene expression levels and the interactions between them as well. The iSubgraph algorithm was capable to detect cooperative regulation of miRNAs and genes even if it occurred only in some patients. Next, the miRNA-mRNA modules were used in an unsupervised class prediction model to discover HCC subgroups via patient clustering by mixture models. The robustness analysis of the mixture model showed that the class predictions are highly stable. Moreover, the Kaplan-Meier survival analysis revealed that the HCC subgroups identified by the algorithm have different survival characteristics. The pathway analyses of the miRNA-mRNA co-modules identified by the algorithm demonstrate key roles of Myc, E2F1, let-7, TGFB1, TNF and EGFR in HCC subgroups. Thus, our method can integrate various omics data derived from different platforms and with different dynamic scales to better define molecular tumor subtypes. iSubgraph is available as MATLAB code at http://www.cs. umd.edu/~ozdemir/isubgraph/.
Contributions of the Atmospheric Radiation Measurement (ARM) Program and the ARM Climate Research Facility to the U.S. Climate Change Science Program

The Earth’s surface temperature is determined by the balance between incoming solar radiation and thermal (or infrared) radiation emitted by the Earth back to space. Changes in atmospheric composition, including greenhouse gases, clouds, and aerosols can alter this balance and produce significant climate change. Global climate models (GCMs) are the primary tool for quantifying future climate change; however, there remain significant uncertainties in the GCM treatment of clouds, aerosol, and their effects on the Earth’s energy balance. The 2007 assessment (AR4) by the Intergovernmental Panel on Climate Change (IPCC) reports a substantial range among GCMs in climate sensitivity to greenhouse gas emissions. The largest contributor to this range lies in how different models handle changes in the way clouds absorb or reflect radiative energy in a changing climate (Solomon et al. 2007). In 1989, the U.S. Department of Energy (DOE) Office of Science created the Atmospheric Radiation Measurement (ARM) Program within the Office of Biological and Environmental Research (BER) to address scientific uncertainties related to global climate change, with a specific focus on the crucial role of clouds and their influence on the transfer of radiation in the atmosphere. To address this problem, BER has adopted a unique two-pronged approach:more » * The ARM Climate Research Facility (ACRF), a scientific user facility for obtaining long-term measurements of radiative fluxes, cloud and aerosol properties, and related atmospheric characteristics in diverse climate regimes. * The ARM Science Program, focused on the analysis of ACRF data to address climate science issues associated with clouds, aerosols, and radiation, and to improve GCMs. This report describes accomplishments of the BER ARM Program toward addressing the primary uncertainties related to climate change prediction as identified by the IPCC. « less
Severe Chronic Bronchitis in Advanced Emphysema Increases Mortality and Hospitalizations

Abstract Background: Chronic bronchitis in COPD has been associated with an increased exacerbation rate, more hospitalizations, and an accelerated decline in lung function. The clinical characteristics of patients with advanced emphysema and chronic bronchitis have not been well described. Methods: Patients randomized to medical therapy in the National Emphysema Treatment Trial were grouped based on their reports of cough and phlegm on the St. George's Respiratory Questionnaire(SGRQ) at baseline: chronic bronchitis(CB+) and no chronic bronchitis(CB–). The patients were similarly categorized into severe chronic bronchitis(SCB+) or no severe chronic bronchitis (SCB–) based on the above definition plus report of chest trouble. Kaplan-Meier survival analysis was used to determine the relationships between chronic bronchitis and severe chronic bronchitis and survival and time to hospitalization. Lung function and SGRQ scores over time were compared between groups. Results: The CB+(N = 234; 38%) and CB- groups(N = 376; 62%) had similar survival (median 60.8 versus 65.7 months, p = 0.19) and time to hospitalization (median 26.9 versus 24.9 months, p = 0.84). The SCB+ group(N = 74; 12%) had worse survival (median 47.7 versus 65.7 months, p = 0.02) and shorter time to hospitalization (median 18.5 versus 26.7 months, p = 0.02) than the SCB- group (N = 536; 88%). Mortality and hospitalization rates were not increased when chest trouble was analyzed by itself. The CB+ and CB–groups had similar lung function and SGRQ scores over time. The SCB+ and SCB–groups had similar lung function over time, but the SCB+ group had significantly worse SGRQ scores. Conclusions: Severe chronic bronchitis is associated with worse survival, shorter time to hospitalization, and worse health-related quality of life.
Arterial remodeling after coronary angioplasty: a serial intravascular ultrasound study.

BACKGROUND Restenosis occurs after 30% to 50% of transcatheter coronary procedures; however, the natural history and pathophysiology of restenosis are still incompletely understood. METHODS AND RESULTS Serial (postintervention and follow-up) intravascular ultrasound imaging was used to study 212 native coronary lesions in 209 patients after percutaneous transluminal coronary angioplasty, directional coronary atherectomy, rotational atherectomy, or excimer laser angioplasty. The external elastic membrane (EEM) and lumen cross-sectional areas (CSA) were measured; plaque plus media (P+M) CSA was calculated as EEM minus lumen CSA. The anatomic slice selected for serial analysis had an axial location within the target lesion at the smallest follow-up lumen CSA. At follow-up, 73% of the decrease in lumen (from 6.6+/-2.5 to 4.0+/-3.7 mm2, P<.0001) was due to a decrease in EEM (from 20.1+/-6.4 to 18.2+/-6.4 mm2, P<.0001); 27% was due to an increase in P+M (from 13.5+/-5.5 to 14.2+/-5.4 mm2, P<.0001). Delta Lumen CSA correlated more strongly with delta EEM CSA (r=.751, P<.0001) than with delta P+M CSA (r=.284, P<.0001). Delta EEM was bidirectional; 47 lesions (22%) showed an increase in EEM. Despite a greater increase in P+M (1.5+/-2.5 versus 0.5+/-2.0 mm2, P=.0009), lesions exhibiting an increase in EEM had (1) no change in lumen (-0.1+/-3.3 versus 3.6+/-2.3 mm2, P<.0001), (2) a reduced restenosis rate (26% versus 62%, P<.0001), and (3) a 49% frequency of late lumen gain (versus 1%, P<.0001) compared with lesions with no increase in EEM. CONCLUSIONS Restenosis appears to be determined primarily by the direction and magnitude of vessel wall remodeling (delta EEM). An increase in EEM is adaptive, whereas a decrease in EEM contributes to restenosis.
Setting up the threshold based on cluster head selection algorithm in wireless sensor networks

For network life time, load balancing and scalability, wireless sensor networks have to configure the network based on local management. Clustering algorithm is for satisfying above requirements. A cluster head selection of this algorithm requires to solve additional communication cost and unequal clustering compared with previous clustering algorithm. So, this paper proposes novel cluster head selection algorithm revised previous clustering algorithm.
VPO1 Mediates ApoE Oxidation and Impairs the Clearance of Plasma Lipids

Objective ApoE is an abundant component of chylomicron, VLDL, IDL, and HDL. It binds to multiple types of lipids and is implicated in cholesterol and triglyceride homeostasis. Oxidation of ApoE plays a crucial role in the genesis of atherosclerosis. It is proposed that heme-containing peroxidases (hPx) are major mediators of lipoprotein oxidization. Vascular peroxidase 1 (VPO1) is a recently-discovered hPx, which is expressed in cardiovascular system, lung, liver etc. and secreted into plasma. Its plasma concentration is three orders of magnitude of that of myeloperoxidase. If VPO1 mediates ApoE oxidation and affects the lipid metabolism remains to be elucidated. Methods Recombinant ApoE and VPO1 were expressed and purified from stably-expressing cell lines deriving from HEK293 cells. ApoE oxidation was carried out by VPO1 in the presence of H2O2 and chloride. ApoE oxidation was verified by a variety of approaches including immunoblot and amino acid analyses. To evaluate the functional changes in VPO1-oxidized ApoE, lipid emulsion particle binding assays were employed. Results Oxidized ApoE binds weaker to lipid emulsion particles, which mimic the large lipid complexes in vivo. In lipid efflux assay, oxidized ApoE showed reduced capability in efflux of lipids from foam cells. Mice administrated with oxidized ApoE via blood exhibited weaker clearance ability of plasma lipids. Conclusions Our data suggest that VPO1 is a new mediator regulating lipid homeostasis, implying a role in genesis and development of atherosclerosis.
The effect of obesity and components of metabolic syndrome on urinary and sexual functions in Saudi men

Objective To establish a possible association between obesity, measured by waist circumference (WC) and body mass index (BMI), and voiding and sexual functions in a random cohort of Saudi men. Materials and methods An outpatient men’s health clinic was set up at King Abdulaziz University Hospital in Jeddah, Saudi Arabia and men were invited to discuss their sexual and urinary functions. The data collected included age, WC, weight, height, blood pressure, history of diabetes, hypertension, and smoking. The International Prostate Symptom Score (IPSS) and the International Inventory of Erectile Function (IIEF-5) questionnaire were used to assess urinary tract symptoms and sexual function, respectively. Serum testosterone, prostate-specific antigen and cholesterol levels were measured and documented. Data were analyzed using the Statistical Package for the Social Sciences. Results We recruited 113 participants. The mean WC and BMI of the men were 104 ± 14.599 cm and 29.706 kg/m2, respectively. Thirty-seven men (32.7%) had an IPSS ≥ 8 points. Sexual disorders were reported in 19 men; 16 men had erectile dysfunction, while three had premature ejaculation. Of the whole cohort, 37 men were diabetic, of which 15 (40.5%) had an IPSS ≥ 8 and 13 (35%) were either overweight or obese. Conclusion Increased WC and BMI were associated with diabetes mellitus and large percentages of voiding and sexual disorders.
Dual Antiplatelet Therapy With Clopidogrel and Aspirin in Symptomatic Carotid Stenosis Evaluated Using Doppler Embolic Signal Detection: The Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) Trial

Background—Evidence for efficacy of dual antiplatelet therapy in stroke is limited. Symptomatic carotid stenosis patients are at high risk of early recurrent stroke. In this group, asymptomatic microembolic signals (MES), detected by transcranial Doppler ultrasound (TCD), are markers of future stroke and transient ischemic attack (TIA) risk. They offer a surrogate marker to evaluate antiplatelet therapy, but no multicenter study has evaluated the feasibility of this approach. Methods and Results—Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) is a randomized, double-blind study in subjects with recently symptomatic ≥50% carotid stenosis. Patients were screened with TCD, and if MES were detected, they were randomized to clopidogrel and aspirin or aspirin monotherapy. Repeated TCD recordings were made on days 2 and 7. MES were detected in 110 of 230 patients by online analysis at baseline, of whom 107 were randomized. Intention-to-treat analysis revealed a significant reduction in the primary end point: 43.8% of dual-therapy patients were MES positive on day 7, as compared with 72.7% of monotherapy patients (relative risk reduction 39.8%; 95% CI, 13.8 to 58.0; P=0.0046). The secondary end point of MES frequency per hour was reduced (compared with baseline) by 61.4% (95% CI, 31.6 to 78.2; P=0.0013) in the dual-therapy group at day 7 and by 61.6% (95% CI, 34.9 to 77.4; P=0.0005) on day 2. There were 4 recurrent strokes and 7 TIAs in the monotherapy group versus no stroke and 4 TIAs in the dual-therapy group that were treatment emergent and ipsilateral to the qualifying carotid stenosis; 2 additional ipsilateral TIAs occurred before treatment started. MES frequency was greater in the 17 patients with recurrent ipsilateral events compared with the 90 without (mean±SD: 24.4±27.7 versus 8.9±11.5 per hour; P=0.0003). Conclusions—In patients with recently symptomatic carotid stenosis, combination therapy with clopidogrel and aspirin is more effective than aspirin alone in reducing asymptomatic embolization. Doppler MES detection is a feasible method to evaluate the efficacy of antiplatelet therapy in multicenter studies.
CrossTalk opposing view: Sleep apnoea causes metabolic syndrome

Co-morbid obstructive sleep apnoea (OSA) and metabolic syndrome (MetS) has been a focus of research since the early 1990s. Whilst it is clear that central obesity is the common factor in the aetiology of both conditions, there is good evidence that OSA, independent of obesity, partly drives the development of MetS through exacerbation of its components (central obesity, hypertriglyceridaemia, hyperglycaemia, hypertension and reduced HDL cholesterol). Indeed, the higher cardiovascular risk with this co-morbidity led to the proposal almost two decades ago of a separate syndrome (Wilcox et al. 1998). Here we provide epidemiological evidence suggesting that untreated OSA is a risk factor for MetS and/or exacerbation of MetS components. We also provide evidence showing that OSA treatment improves MetS components. Finally, we argue that MetS is a blunt measure of poor metabolic health, and that more sensitive functional measures do clearly improve when co-morbid OSA is effectively treated, thereby supporting the case for causality.
Course Setting as a Prevention Measure for Overuse Injuries of the Back in Alpine Ski Racing

Background: A combination of frontal bending, lateral bending, and torsion in the loaded trunk has been suggested to be a mechanism leading to overuse injuries of the back in Alpine ski racing. However, there is limited knowledge about the effect of course setting on the aforementioned back-loading patterns. Purpose: To investigate the effect of increased gate offset on the skier’s overall trunk kinematics and the occurring ground-reaction forces and to compare these variables between the competition disciplines giant slalom (GS) and slalom (SL). Study Design: Controlled laboratory study. Methods: Ten top-level athletes were divided into GS and SL groups. Both groups performed a total of 240 GS and 240 SL turns at 2 different course settings. The overall trunk movement components (frontal bending, lateral bending, and torsion angle) were measured using 2 inertial measurement units fixed on the sacrum and sternum. Total ground-reaction forces were measured by pressure insoles. Results: In SL, ground-reaction force peaks were significantly lower when the gate offset was increased, while in GS, no differences between course settings were observed. During the turn phase in which the highest spinal disc loading is expected to occur, the back-loading patterns in both GS and SL included a combination of frontal bending, lateral bending, and torsion in the loaded trunk. SL was characterized by shorter turns, lower frontal and lateral bending angles after gate passage, and a trend toward greater total ground-reaction force peaks compared with GS. Conclusion: Course setting is a reasonable measure to reduce the skier’s overall back loading in SL but not in GS. The distinct differences observed between GS and SL should be taken into account when defining discipline-specific prevention measures for back overuse injuries. Clinical Relevance: To reduce the magnitude of the overall back loading, in SL, minimal gate offsets should be avoided. Prevention measures in GS might particularly need to control and/or reduce the magnitude of frontal and lateral bending in the loaded trunk, whereas prevention measures in SL might especially need to mitigate the short and high total ground-reaction force peaks.