Miracle-dz/UniFAR-FTUs huggingface dataset:
Community study of role of viral infections in exacerbations of asthma in 9-11 year old children

Abstract Objective: To study the association between upper and lower respiratory viral infections and acute exacerbations of asthma in schoolchildren in the community. Design: Community based 13 month longitudinal study using diary card respiratory symptom and peak expiratory flow monitoring to allow early sampling for viruses. Subjects: 108 Children aged 9-11 years who had reported wheeze or cough, or both, in a questionnaire. Setting: Southampton and surrounding community. Main outcome measures: Upper and lower respiratory viral infections detected by polymerase chain reaction or conventional methods, reported exacerbations of asthma, computer identified episodes of respiratory tract symptoms or peak flow reductions. Results: Viruses were detected in 80% of reported episodes of reduced peak expiratory flow, 80% of reported episodes of wheeze, and in 85% of reported episodes of upper respiratory symptoms, cough, wheeze, and a fall in peak expiratory flow. The median duration of reported falls in peak expiratory flow was 14 days, and the median maximum fall in peak expiratory flow was 81 1/min. The most commonly identified virus type was rhinovirus. Conclusions: This study supports the hypothesis that upper respiratory viral infections are associated with 80-85% of asthma exacerbations in school age children. Key messages Key messages In this study common cold viruses were found in 80-85% of reported exacerbations of asthma in children Rhinoviruses, which cause most common colds, accounted for two thirds of viruses detected Analysis of diary cards also showed large numbers of similar but less severe episodes that may also be viral in origin
Central Banking in Transition Countries

In the 1990s, the issues of central banking and central bank independence have gained increasing attention, in part owing to the role of the future European central bank, but also owing to the emergence of transition countries and the role of central banks in these countries. The main focus of the paper is on the preconditions of disinflation and successful stability policy in transition countries, paying special attention to the institutional requirements and to the choice of nominal anchors.
Time Consistency of Fiscal and Monetary Policy

The problem of time inconsistency arises from two different sources. First, as shown by Guillermo A. Calvo (1978), the re is an incentive for each government to engage in an initial unanti cipated inflation. Second, as discussed by Robert E. Lucas and Nancy L. Stokey (1983), there is an incentive for each government to deviat e from the path of taxes announced by the preceding government. In th is paper, it is shown that these two sources of time inconsistency ca n be removed by a particular method of debt management, involving bot h nominal and indexed government bonds of various maturities. Copyright 1987 by The Econometric Society.
Optimal Capital Structure Model for BOT Power Projects in Turkey

Interest in the Build/Operate/Transfer (BOT) scheme for infrastructure projects has been growing rapidly, and numerous projects have been implemented around the world. Through BOT projects, a government reallocates the risks and rewards in the development of large infrastructure projects to the private sector. One key aspect to the successful implementation of the BOT concept in any country is the raising of finance by project sponsors. Financial engineering techniques and capital structuring skills are required to find the proper mix of debt and equity and to achieve successful financing for the proposed project. The objective of this paper is to present a simplified model to determine the optimum equity level for decisionmakers at the evaluation stage of a BOT hydroelectric power plant (HEPP) project in Turkey, which takes place immediately after the completion of the feasibility study. The resulting model is the combination of a financial model and a linear programming model that incorporates an objective of maximizing the return of the project from the equity holder's point of view. To show versatility of the model, a real case study is conducted. Thus, this research is concerned with the determination of an equity funding level in BOT project finance. There are different equity levels found in BOT HEPP projects, and there is a need for such a model to determine optimal capital structure, which would assist the project sponsors to ensure that the equity level necessary for optimal capital structure is available prior to the project implementation stage.
Natural fatty acid synthase inhibitors as potent therapeutic agents for cancers: A review

Abstract Context Fatty acid synthase (FAS) is the only mammalian enzyme to catalyse the synthesis of fatty acid. The expression level of FAS is related to cancer progression, aggressiveness and metastasis. In recent years, research on natural FAS inhibitors with significant bioactivities and low side effects has increasingly become a new trend. Herein, we present recent research progress on natural fatty acid synthase inhibitors as potent therapeutic agents. Objective This paper is a mini overview of the typical natural FAS inhibitors and their possible mechanism of action in the past 10 years (2004–2014). Method The information was collected and compiled through major databases including Web of Science, PubMed, and CNKI. Results Many natural products induce cancer cells apoptosis by inhibiting FAS expression, with fewer side effects than synthetic inhibitors. Conclusion Natural FAS inhibitors are widely distributed in plants (especially in herbs and foods). Some natural products (mainly phenolics) possessing potent biological activities and stable structures are available as lead compounds to synthesise promising FAS inhibitors.
Is there a divergence between objective measures and subjective perceptions of poverty trends : evidence from West and Central Africa

Several sub-Saharan African countries have succeeded at increasing their economic growth rate in recent years, and this has translated into substantial poverty reduction according to objective measures based on household survey data. At the same time, many people do not feel that the poverty situation has been improving in their country or community, and this is a source of concern for elected policymakers. To what extent is there a divergence between objective measures and subjective perceptions of poverty trends, and what may explain this divergence: the objective of this note is to document and discuss this issue using data from West and Central Africa and results from a series of poverty assessments recently completed at the World Bank.
Complete degradation of polychlorinated hydrocarbons by a two-stage biofilm reactor

A two-stage anaerobic-aerobic biofilm reactor successfully degraded a mixture of chlorinated organic compounds to water-soluble metabolic intermediates and carbon dioxide. Reductive dechlorination of hexachlorobenzene (HCB), tetrachloroethylene (PCE), and chloroform (CF) occurred on all tested primary carbon sources such as glucose, methanol, and acetate. However, the extent of dechlorination was maximum when the anaerobic biofilm column was fed acetate as a primary carbon source. HCB, PCE, and CF were dechlorinated to the levels of tri- and dichlorinated products (99, 80, and 32%, respectively) with acetate in the feed. This is important, since these less-chlorinated compounds can be metabolized by the aerobic biofilm. The effluent from the anaerobic biofilm column was fed directly into the aerobic column. After both columns, the total amount transformed into nonvolatile intermediates and carbon dioxide was 94, 96, and 83% for [14C]HCB, [14C]trichloroethylene, and [14C]CF, respectively. This research shows the potential application of this novel two-stage bioreactor system for treating groundwaters and industrial effluents composed of highly chlorinated aliphatic and aromatic hydrocarbons.
Je-chun-jun induced apoptosis of human cervical carcinoma HeLa cells.

AIM To study the mechanism of je-chun-jun (JCJ)-inducing the apoptosis of the human cervical carcinoma, HeLa cells. METHODS The cell viability was assessed using MTT assay. The optical density was measured at 570 nm. The caspase activity was measured using 50 mmol/L of fluorogenic substrate, AC-DEVD-AMC (caspase-3), AC-VEID-AMC (caspase-8) or AC-LEHD-AFC (caspase-9). To confirm the expression of proteins, Western blotting was performed. To detect the characteristic of apoptosis chromatin condensation, HeLa cells were stained with Hoechst 33258 in the presence of JCJ. For the cell cycle analysis, HeLa cells were incubated with Propidium iodide (PI) solution. Fluorescence intensity of cell cycle was measured using flow cytometry system. RESULTS The loss of viability occurred following the exposure of 10 g/L JCJ. Cells treated with 10 g/L JCJ for 3 d exhibited the apoptotic morphology (brightly blue-fluorescent condensed nuclei by Hoechst 33258-staining) and the reduction of cell volume. Cells incubated with JCJ for 48 h were arrested at the G1 phase of cell cycle and their G1 checkpoint related gene products such as cyclin D1 were transiently decreased. We showed that JCJ induced the p38 MAPK activation in HeLa cells. The p38 MAPK inhibitor, SB203580 protected Hela cells from the JCJ-induced death as well as intervened the JCJ-induced accumulation of cells at the G1 phase. In contrast, MEK1 (-ERK upstream) inhibitor, PD98059 had no effect on HeLa cells. CONCLUSION JCJ induced cell cycle arrest and apoptosis of HeLa cells through p38 MAPK pathway.
Virtue of intransparency: coordination-free, scale-free private Internets

Based on a recent thesis, a canonical networking scheme is described that would eliminate address space coordination and limit the need for route discovery in a manner that is scale-free, is orthogonal to existing protocol suites, and provides near-instantaneous responsiveness to change. This also makes it inherently independent of coordinated global name or address spaces like the DNS and IP. It enables independently deployed private and invisible Internets that would be extremely lightweight, efficient and fast, and can be created, grown, split or merged by the users themselves over the existing infrastructure, using no coordination or network administration skills
The front end of new product development: a Canadian survey

Despite the importance of the early stages of a product's life, very little attention has been paid to empirically testing the activities performed in the front end of new product development. This article presents the results of a survey of 53 individuals from fifteen high technology firms in the integrated circuit board industry. Our study adopts Cooper's (1988) ‘predevelopment’ model consisting of idea generation, product definition and project evaluation stages, and probes the activities undertaken in each stage. Particular activities were found to play pivotal roles in achieving the objectives of each stage. The results present a clarified view of front end activities that can be used as a starting point for adequately preparing products for development and market success.
An audit of ambulatory laparoscopic cholecystectomy in a Singapore institution: are we ready for day-case laparoscopic cholecystectomy?

BACKGROUND Day-Case laparoscopic cholecystectomy (LC) is practiced in many countries. However, this has yet to be widely accepted in Singapore. This study aims to determine the potential success rate of day-case LC in our institution. PATIENT AND METHODS We retrospectively assessed the proportion of our Ambulatory Surgery 23 hour (AS23) LC patients that met discharge criteria. Our proposed same-day discharge criteria include minimal pain, ability to tolerate feeds, ambulate independently and void spontaneously after 6-8 hours of monitoring. RESULTS From January 2005 to December 2006, of 405 patients listed for elective LC, 84% of patients were admitted to our AS23 ward. Patients with previous biliary sepsis or pancreatitis or who need laparoscopic common bile duct exploration (LCBDE) were included. The other 66 were admitted as inpatient. Forty-one of them were admitted due to conversion. A history of cholecystitis or cholangitis was a significant predictor of conversion to open surgery (OR=5.73 and 5.74 respectively, p<0.001). Of the 339 patients, 66% of them fulfilled all four criteria within eight hours of monitoring. Therefore, based on an intention-to-treat analysis, 51.2% fulfilled all four criteria and could potentially be discharged the same day. No predictor for failure was identified, including presence of co-morbidities, duration of operation, surgeon's grade and additional procedures like LCBDE. CONCLUSION Using our current inclusion criteria, we projected a success rate of at least 50% with the implementation of day-case LC. With the attendant advantages of cost savings and reduced resource utilization, it is therefore worthwhile to start it in Singapore.
Strategic management of e-learning implementation programme in Malaysian public universities issues on policy and key initiatives

The main aim of this study was to investigate the current status of e-learning policy and key initiatives of e-learning implementation program in Malaysian public universities (MPU). The methodology used was the generic qualitative research approach where interviews of respondents from 12 MPU and analysis of relevant key documents were used for gathering the necessary data. The findings revealed that there was no single document that could be referred as the national policy for e-learning in MPU, and there were only three universities that have already a formal and well documented e-learning policy. Those policies apparently lack of many important components as recommended in the literature. At the end of this paper, some important measures were outlined and suggested to improve the e-learning implementation programme in MPU.
Optimal service speeds in a competitive environment

This is a study of the economic behavior of vendors of service in competition. A simple model with two competing exponential servers and Poisson arrivals is considered. Each server is free to choose his own service rate at a cost per time unit that is strictly convex and increasing. There is a fixed reward to a server for each customer that he serves. The model is designed to study one specific aspect of competition, namely, competition in speed of service as a means for capturing a larger market share in order to maximize long-run expected profit per time unit. A two-person strategic game is formulated and its solutions are characterized. Depending on the revenue per customer served and on the cost of maintaining service rates, the following three situations may arise: i a unique symmetric strategic Nash equilibrium in which expected waiting time is infinite; ii a unique symmetric strategic equilibrium in which expected waiting time is finite; and iii several, nonsymmetric strategic equilibria with infinite expected waiting time. An explicit expression for the market share of each server as a function of the service rates of the two servers is also given.
Commonality in the LME aluminum and copper volatility processes through a FIGARCH lens

We consider dynamic representation of spot and three month aluminium and copper volatilities. These are the two most important metals traded in the London Metal Exchange (LME). They share common business cycle factors and are traded under identical contract specifications. We apply the bivariate FIGARCH model which allows parsimonious representation of long memory volatility processes. Our results show that spot and three month aluminium and copper volatilities follow long memory processes, that they exhibit a common degree of fractional integration and that the processes are symmetric. However, there is no evidence that the processes are fractionally cointegrated. This high degree of commonality may result from the common LME trading process.
African american women, hair care, and health barriers.

OBJECTIVES The objective of this study was to elucidate the prevalence of hair loss among African American women; explore the psychosocial impact of hair grooming difficulties; and examine both perceptions related to physician encounters in this group and the relationship between hair grooming, physical activity, and weight maintenance. DESIGN An anonymous retrospective and qualitative survey, the Hair Care Assessment Survey, is an 18-question novel survey instrument designed at the Henry Ford Hospital Department of Dermatology Multicultural Dermatology Center. SETTING The Hair Care Assessment Survey was distributed at church-related functions at predominantly African American metropolitan Detroit churches. PARTICIPANTS Two hundred African American women from metropolitan Detroit, Michigan, aged 21 to 83. MEASUREMENTS The Hair Care Assessment Survey collected data relating to hair loss and hair care, psychosocial experiences relating to hair loss, and hair care as it relates to exercise and body weight management. Data was collected on doctor-patient hair-related medical visits and experiences with commercially available ethnic hair care products. RESULTS More than 50 percent reported excessive hair loss. Twenty-eight percent had visited a physician to discuss hair issues, but only 32 percent felt their physician understood African American hair. Forty-five percent reported avoiding exercise because of hair concerns, and 22 percent felt that their hair impeded maintaining healthy body weight. CONCLUSION Hair loss affects a compelling number of African American women, and a significant number express dissatisfaction in hair-related physician encounters. Additionally, hair styling problems present a serious impediment to physical activity and weight management among this already high-risk population.
Muscle fatigue of quadriceps in paraplegics: Comparison between single vs. multi-pad electrode surface stimulation

We hypothesize that the asynchronous low frequency stimulation of pads within multi-pad electrode will be less fatiguing compared to the conventional stimulation (two single pad electrodes) when generating comparable large forces of paralyzed human muscles. The experiments to verify the hypothesis were conducted on quadriceps of six individuals with chronic spinal cord injury (ASIA score A) who had not participated in any electrical stimulation program. The following stimulation protocols were compared: stimulation with a self adhesive 7 cm × 10 cm Pals Platinum cathode positioned over the top of the quadriceps (f = 3D 40 Hz), and four oval 4 cm × 6 cm cathodes positioned over the proximal upper leg (f = 3D 16 Hz). The anode in both cases was the 7 cm × 10 cm Pals Platinum electrode positioned over the distal part of the quadriceps. We measured the knee joint torque vs. time with a custom made apparatus, and estimated the interval before the knee joint torque decreased to 70% of the maximum. Mean fatigue interval increase for the four-pad stimulation protocol vs. single-pad stimulation protocol was 153.18%. This suggests that the use of multi-pad electrodes is favorable in cases where a prolonged stimulation of muscles is required.
The Dileucine Motif Within the Tail of MPR46 is Required for Sorting of the Receptor in Endosomes

The cytoplasmic tail of MPR46 carries a leucine‐based motif that is required for the sorting of lysosomal enzymes by the receptor. In addition, it is one of three independent, but functionally redundant, internalization signals present in the cytoplasmic tail of MPR46. We have analyzed a mutant of MPR46, in which the dileucine pair was replaced by alanines (MPR46 LL/AA) with respect to its intracellular distribution and trafficking. Ultrastructural analysis of cells expressing the MPR46 LL/AA mutant revealed that the substitution of the dileucine pair causes a shift of the receptor distribution from the TGN, where it is packaged into AP1‐containing vesicles, to vesicular structures distributed throughout the cytoplasm. The vesicles could be identified as early endosomes with internalized BSA‐gold and rab5 as markers. By analyzing the receptor trafficking biochemically, we found that return of the LL/AA mutant receptor from the plasma membrane/endosome pool back to the TGN was impaired, while recycling from endosomes to the plasma membrane was enhanced. In conclusion, our data indicate that the dileucine motif in the MPR46 tail is required for a sorting event in endosomes.
'As required' medication regimens for seriously mentally ill people in hospital.

BACKGROUND Drugs used to treat psychotic illnesses may take weeks to be effective. In the interim, additional 'as required' doses of medication can be used to calm patients in psychiatric wards. The practice is widespread, with 20% to 50% of people on acute psychiatric wards receiving at least one 'as required' dose of psychotropic medication during their admission. OBJECTIVES To compare the effects of 'as required' medication regimens with regular patterns of medication for the treatment of psychotic symptoms or behavioural disturbance, thought to be secondary to psychotic illness. These regimens may be given alone or in addition to any regular psychotropic medication for the long-term treatment of schizophrenia or schizophrenia-like illnesses. SEARCH METHODS We searched the Cochrane Schizophrenia Group's Trials Register, which is based on regular searches of MEDLINE, EMBASE, PubMed, CINAHL, BIOSIS, AMED, PsycINFO and registries of clinical trials, in November 2001, March 2006, July 2012 andOctober 2013. SELECTION CRITERIA We aimed to include all relevant randomised controlled trials involving hospital inpatients with schizophrenia or schizophrenia-like illnesses, comparing any regimen of medication administered for the short-term relief of behavioural disturbance, or psychotic symptoms, to be given at the discretion of ward staff ('as required', 'prn') with fixed non-discretionary patterns of drug administration of the same drug(s). This was in addition to regular psychotropic medication for the long-term treatment of schizophrenia or schizophrenia-like illnesses where prescribed. DATA COLLECTION AND ANALYSIS We independently inspected abstracts and papers for inclusion. If trials had been found, we would have extracted data from the papers and quality assessed the data. For dichotomous data we would have calculated the risk ratios (RR), with the 95% confidence intervals (CI). We would have conducted analyses on an intention-to-treat basis. If data were available we would have completed a 'Summary of findings' table using GRADE. MAIN RESULTS We have not been able to identify any randomised trials comparing 'as required' medication regimens to regular regimens of the same drug. Our main outcomes of interest were important changes in (i) mental state, (ii) behaviour, (iii) dose of medication used, (iv) adverse events, (v) satisfaction with care and (iv) cost of care. AUTHORS' CONCLUSIONS There is currently no evidence from within randomised trials to support this common practice. Current practice is based on clinical experience and habit rather than high quality evidence.
True and Fair — An Imaginary View

The recent collapses of major Australian corporations and the human and economic consequences have emphasised the need for a new approach to auditing in Australia to fix the culture of complacency. The challenge is to continue to persuade directors, auditors and ASIC to better understand what the law requires, and to pressure government to create the conditions to ensure that ASIC undertakes appropriate enforcement.