Miracle-dz/UniFAR-FTUs huggingface dataset:
Electromagnetic bone segment tracking to control femoral derotation osteotomy—A saw bone study

Correction of rotational gait abnormalities is common practice in pediatric orthopaedics such as in children with cerebral palsy. Femoral derotation osteotomy is established as a standard treatment, however, different authors reported substantial variability in outcomes following surgery with patients showing over‐ or under‐correction. Only 60% of the applied correction is observed postoperatively, which strongly suggests intraoperative measurement error or loss of correction during surgery. This study was conducted to verify the impact of error sources in the derotation procedure and assess the utility of a newly developed, instrumented measurement system based on electromagnetic tracking aiming to improve the accuracy of rotational correction. A supracondylar derotation osteotomy was performed in 21 artificial femur sawbones and the amount of derotation was quantified during the procedure by the tracking system and by nine raters using a conventional goniometer. Accuracy of both measurement devices was determined by repeated computer tomography scans. Average derotation measured by the tracking system differed by 0.1° ± 1.6° from the defined reference measurement . In contrast, a high inter‐rater variability was found in goniometric measurements (range: 10.8° ± 6.9°, mean interquartile distance: 6.6°). During fixation of the osteosynthesis, the tracking system reliably detected unintentional manipulation of the correction angle with a mean absolute change of 4.0° ± 3.2°. Our findings show that conventional control of femoral derotation is subject to relevant observer bias whereas instrumental tracking yields accuracy better than ±2°. The tracking system is a step towards more reliable and safe implementation of femoral correction, promising substantial improvements of patient safety in the future. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:1106–1112, 2017.
Research on Applications of the Internet of Things in the Smart Grid

The internet of things (IoT) technology has great potential in obtaining, analyzing, processing, controlling and feeding back the information of entity properties (location, status, behavior, characteristic, etc.), which will play an active role in promoting the development of smart grid. In this paper, we apply the IoT technology in the smart grid field. A kind of system architecture of smart grid is built according to the IoT system architecture. The system architecture of smart grid is divided into three layers -- the perception layer, the communication layer and the application layer. The application of IoT technology in every layer of the system architecture of the smart grid is analyzed and discussed in detail. Finally, the application prospect and problems which should be solved are forecast. It is found that the IoT technology will make smart grid more efficient, more intelligent, more secure and more convenient.
Nelfinavir is effective in inhibiting the multiplication and aspartic peptidase activity of Leishmania species, including strains obtained from HIV-positive patients

Objectives There is a general lack of effective and non-toxic chemotherapeutic agents for leishmaniasis and there is as yet no study about the effect of HIV peptidase inhibitors (HIV PIs) on Leishmania/HIV-coinfected patients. In the present work, we performed a comparative analysis of the spectrum of action of HIV PIs on different Leishmania spp. , including strains obtained from HIV-positive patients receiving or not receiving antiretroviral treatment. Methods The effects of nelfinavir and saquinavir on Leishmania proliferation were assessed by means of a colorimetric assay (MTT). Subsequently, the effect of nelfinavir on aspartic peptidase activity from Leishmania spp. was assessed by following the degradation of the fluorogenic substrate MCA-G-K-P-I-L-F-F-R-L-K-DNP-Arg-NH2. Results Nelfinavir was capable of significantly reducing the multiplication of many Leishmania reference strains and isolates obtained from HIV-positive patients receiving or not receiving antiretroviral treatment. Leishmania major growth was inhibited by ∼50%, while all other flagellates were strongly inhibited (at least 94%), except for a Leishmania chagasi strain obtained from an HIV-positive patient under treatment with highly active antiretroviral therapy (HAART). Culture of this isolate in the presence of nelfinavir induced a considerable reduction in the aspartic peptidase activity. In addition, nelfinavir was also capable of inhibiting the aspartic peptidase activity of all Leishmania strains tested. Conclusions The present data contribute to the study of the effect of HIV PIs on Leishmania infection and add new insights into the possibility of exploiting aspartic peptidases as promising targets in order to generate novel medications to treat leishmaniasis.
Percutaneous CT biopsy of chest lesions: an in vitro analysis of the effect of partial volume averaging on needle positioning.

OBJECTIVE Accurate needle biopsy of chest lesions requires knowledge of both the direction of the needle and the exact location of the tip of the needle. The purpose of this study was to analyze and illustrate the relationships between the location of the nodule, the size of the nodule, the CT slice thickness, and the needle length. An understanding of these relationships should minimize localization errors due to partial volume averaging and thus increase the accuracy of biopsies. MATERIALS AND METHODS Geometric principles were used to determine mathematical relationships between the size of the nodule, the CT slice thickness, the length of the needle, and the direction of the needle. A styrofoam model simulating the patient and the lesion to be sampled was developed so that radiographs and CT scans of the model could be obtained with different needle placements to illustrate the phenomenon of partial volume averaging. RESULTS The accuracy of the CT-guided biopsy can be increased by reducing the CT slice thickness, using longer needles, minimizing the distance to be traversed within the patient, and maximizing the portion of the lesion contained in the CT section used for needle tip localization. Mathematical equations developed from the in vitro model can be used to select the most appropriate CT section and the best length and angle of the needle. CT scans of the model illustrate the use of these equations. CONCLUSION We found these principles helpful in improving the accuracy of CT needle biopsies, particularly when the lesions are very small and when an angled approach is required. Ideally, the smallest possible CT slice thickness and the longest possible needles should be used, but some practical limitations exist.
Categorisation of Mobile EEG: A Researcher's Perspective

Researchers are increasingly attempting to undertake electroencephalography (EEG) recordings in novel environments and contexts outside of the traditional static laboratory setting. The term “mobile EEG,” although commonly used to describe many of these undertakings, is ambiguous, since it attempts to encompass a wide range of EEG device mobility, participant mobility, and system specifications used across investigations. To provide quantitative parameters for “mobile EEG,” we developed a Categorisation of Mobile EEG (CoME) scheme based upon scoring of device mobility (D, from 0, off-body, to 5, head-mounted with no additional equipment), participant mobility (P, from 0, static, to 5, unconstrained running), system specification (S, from 4, lowest, to 20, highest), and number of channels (C) used. The CoME scheme was applied to twenty-nine published mobile EEG studies. Device mobility scores ranged from 0D to 4D, participant mobility scores from 0P to 4P, and system specification scores from 6S to 17S. The format of the scores for the four parameters is given, for example, as (2D, 4P, 17S, 32C) and readily enables comparisons across studies. Our CoME scheme enables researchers to quantify the degree of device mobility, participant mobility, and system specification used in their “mobile EEG” investigations in a standardised way.
Effects of the infectious period distribution on predicted transitions in childhood disease dynamics

The population dynamics of infectious diseases occasionally undergo rapid qualitative changes, such as transitions from annual to biennial cycles or to irregular dynamics. Previous work, based on the standard seasonally forced ‘susceptible–exposed–infectious–removed’ (SEIR) model has found that transitions in the dynamics of many childhood diseases result from bifurcations induced by slow changes in birth and vaccination rates. However, the standard SEIR formulation assumes that the stage durations (latent and infectious periods) are exponentially distributed, whereas real distributions are narrower and centred around the mean. Much recent work has indicated that realistically distributed stage durations strongly affect the dynamical structure of seasonally forced epidemic models. We investigate whether inferences drawn from previous analyses of transitions in patterns of measles dynamics are robust to the shapes of the stage duration distributions. As an illustrative example, we analyse measles dynamics in New York City from 1928 to 1972. We find that with a fixed mean infectious period in the susceptible–infectious–removed (SIR) model, the dynamical structure and predicted transitions vary substantially as a function of the shape of the infectious period distribution. By contrast, with fixed mean latent and infectious periods in the SEIR model, the shapes of the stage duration distributions have a less dramatic effect on model dynamical structure and predicted transitions. All these results can be understood more easily by considering the distribution of the disease generation time as opposed to the distributions of individual disease stages. Numerical bifurcation analysis reveals that for a given mean generation time the dynamics of the SIR and SEIR models for measles are nearly equivalent and are insensitive to the shapes of the disease stage distributions.
The significance of frequent and independent p53 and bcl-2 expression in large-cell neuroendocrine carcinomas of the lung.

Both p53 and bcl-2 genes are involved in regulating cell death. Reports, however, concerning the relationship between p53 and bcl-2 expression are contradictory. Large-cell neuroendocrine carcinoma (LCNEC) of the lung is a newly recognized clinicopathologic entity. p53 mutation and bcl-2 overexpression are frequent in small-cell lung carcinoma (SCLC), and we observed a close correlation between bcl-2 expression and cellular neuroendocrine (NE) differentiation in non-SCLC, so we speculated that LCNEC, an NE tumor closely related to SCLC, would exhibit high incidence of both p53 alteration and bcl-2 expression. Immunohistochemical expression of p53 and bcl-2 was evaluated on consecutive sections of 26 LCNECs, including 4 combined LCNECs. p53 accumulation and diffuse bcl-2 staining were observed in 18 (69.2%) of 26 and 24 (92.3%) of 26 LCNECs, respectively, but their immunoreactivities showed no fixed distribution relevance on consecutive sections in individual tumors. Statistical analyses yielded no relationship between p53 and bcl-2 expression (P = .47). In all of the four combined LCNECs, p53 was identically either positive or negative in both tumor cell populations with and without NE differentiation. bcl-2 immunoreactivity was observed only for the tumor cells with NE phenotype in three of the four combined LCNECs and was diffuse among the NE tumor cells but geographic in distribution among the non-NE tumor cells of the remaining one combined LCNEC. Thus, our present findings suggest that p53 and bcl-2 are expressed independently and might have distinct expression significance in LCNECs. A high incidence of p53 expression in LCNECs and equal p53 expression profiles in NE and non-NE tumor cell populations of combined LCNECs suggest that p53 alteration is primarily involved in the tumorigenesis of LCNEC. On the other hand, frequent bcl-2 expression in pure LCNECs and selective bcl-2 expression in tumor cells with NE phenotype in combined LCNECs are suggestive of a role for bcl-2 in regulating cellular NE differentiation.
Social-Relational Topic Model for Social Networks

Social networking services, such as Twitter and Sina Weibo, have tremendous popularity in recent years. Mass of short texts and social links are aggregated into these service platforms. To realize personalized services on social network, topic inference from both short texts and social links plays more and more important role. Most conventional topic modeling methods focus on analyzing formal texts, e.g., papers, news and blogs, and usually assume that the links are only generated by topical factors. As a result, on social network, the learned topics of these methods are usually affected by topic-irrelevant links. Recently, a few approaches use artificial priors to recognize the links generated by the popularity factor in topic modeling. However, employing global priors, these methods can not well capture the distinct properties of each link and still suffer from the effect of topic-irrelevant links. To address the above limitations, we propose a novel Social-Relational Topic Model (SRTM), which can alleviate the effect of topic-irrelevant links by analyzing relational users' topics of each link. SRTM jointly models texts and social links for learning the topic distribution and topical influence of each user. The experimental results show that, our model outperforms the state-of-the-arts in topic modeling and social link prediction.
Integrating a space for teacher interaction into an educative curriculum: design principles and teachers’ use of the iPlan tool

ABSTRACT Implementation of reform curricula requires teachers to adopt new approaches to teaching. Research has provided promising results about the influence of educative curriculum on teachers’ learning and instruction. However, this approach generally focuses on teachers as isolated learners. Using a design-based research approach, the authors developed a web-based tool, iPlan, which provides access to educative curriculum materials in an online interactive learning platform. iPlan encourages social interaction among teachers, in particular their modifications and reflections on teaching with the curriculum materials. The authors describe design principles, assessing successful and unsuccessful aspects of the resulting platform through semi-structured interviews with teachers within the context of implementation of a high school biology curriculum. Analysis of the interviews revealed which structures of this online platform were used by the teachers, as well as why and how they were used. The study provides implications for designing educative and online systems for teacher learning.
Head movements based control of an intelligent wheelchair in an indoor environment

This paper presents a user-friendly human machine interface (HMI) for hands-free control of an electric powered wheelchair (EPW). Its two operation modes are based on head movements: Mode 1 uses only one head movement to give the commands, and Mode 2 employs four head movements. An EEG device, namely Emotiv EPOC, has been deployed in this HMI to obtain the head movement information of users. The proposed HMI is compared with the joystick control of an EPW in an indoor environment. The experimental results show that Control Mode 2 can be implemented at a fast speed reliably, achieving a mean time of 67.90 seconds for the two subjects. However, Control Mode 1 has inferior performance, achieving a mean time of 153.20 seconds for the two subjects although it needs only one head movement. It is clear that the proposed HMI can be effectively used to replace the traditional joystick control for disabled and elderly people.
Human Bubr1 Is a Mitotic Checkpoint Kinase That Monitors Cenp-E Functions at Kinetochores and Binds the Cyclosome/APC

Human cells express two kinases that are related to the yeast mitotic checkpoint kinase BUB1. hBUB1 and hBUBR1 bind to kinetochores where they are postulated to be components of the mitotic checkpoint that monitors kinetochore activities to determine if chromosomes have achieved alignment at the spindle equator (Jablonski, S.A., G.K.T. Chan, C.A. Cooke, W.C. Earnshaw, and T.J. Yen. 1998. Chromosoma. 107:386–396). In support of this, hBUB1 and the homologous mouse BUB1 have been shown to be important for the mitotic checkpoint (Cahill, D.P., C. Lengauer, J. Yu, G.J. Riggins, J.K. Willson, S.D. Markowitz, K.W. Kinzler, and B. Vogelstein. 1998. Nature. 392:300–303; Taylor, S.S., and F. McKeon. 1997. Cell. 89:727–735). We now demonstrate that hBUBR1 is also an essential component of the mitotic checkpoint. hBUBR1 is required by cells that are exposed to microtubule inhibitors to arrest in mitosis. Additionally, hBUBR1 is essential for normal mitotic progression as it prevents cells from prematurely entering anaphase. We establish that one of hBUBR1's checkpoint functions is to monitor kinetochore activities that depend on the kinetochore motor CENP-E. hBUBR1 is expressed throughout the cell cycle, but its kinase activity is detected after cells have entered mitosis. hBUBR1 kinase activity was rapidly stimulated when the spindle was disrupted in mitotic cells. Finally, hBUBR1 was associated with the cyclosome/anaphase-promoting complex (APC) in mitotically arrested cells but not in interphase cells. The combined data indicate that hBUBR1 can potentially provide two checkpoint functions by monitoring CENP-E–dependent activities at the kinetochore and regulating cyclosome/APC activity.
Regulation of Black Pepper Inflorescence Quantity by Shading at Different Growth Stages

Black pepper is a perennial plant that can bloom throughout the year. It is generally expected that pepper inflorescence quantity could be minimized at the nonfull‐bloom stage. The objective of this study was to find an appropriate shading measure that could inhibit blooming at other growing stages except the full‐bloom stage and did not cause any reduction in pepper yield and quality. In this study, pepper trees were shaded up to 15%, 30%, 60% and 75%, respectively, and the inflorescence quantity, photosynthetic characteristics, pepper yield and quality traits were investigated at every growing stage. The results showed that the effect of shading on pepper yield decreased as time progressed. Shading treatment did not alter the composition of piperine and volatile oil, but reduced the moisture content. Based on the correlation between photosynthetic parameter and inflorescence number, the appropriate shading intensities for regulating inflorescence quantity at different phenological stages were determined. Moreover, it was found that the regulation of inflorescence quantity could be achieved by controlling leaf temperature during recovery to filling period. This research outcome also will give us some guidelines to develop other management strategies that control leaf temperature and regulate inflorescence quantity to consequently improve pepper yield.
IMPLEMENTASI PROJECT BASED LEARNING BERBASIS POTENSI LOKAL UNTUK MENINGKATKAN KETERAMPILAN PROSES SAINS DAN DISPOSISI FISIKA

Penelitian ini bertujuan untuk mendapatkan gambaran peningkatan keterampilan proses sains dan disposisi fisika mahasiswa pendidikan fisika yang mengimplementasikan model Project Based Learning berbasis potensi lokal pada perkuliahan fisika dasar I. Metode penelitian yang digunakan adalah metode pre-eksperimental one group pre-post test design . Pretest dilakukan untuk mengukur keterampilan proses sains mahasiswa sebelum mendapat perlakuan. Setelah mahasiswa mendapatkan pembelajaran fisika dasar I dengan Project Based Learning berbasis potensi lokal, keterampilan proses sains mahasiswa diukur dengan menggunakan posttest . Posttest dilakukan sebanyak tiga kali agar tergambar peningkatan keterampilan proses sains. Data disposisi mahasiswa fisika diukur dengan menggunakan angket disposisi. Hasil penelitian dan analisis data menyimpulkan bahwa Implementasi Project Based Learning berbasis potensi lokal pada perkuliahan fisika dasar dapat meningkatkan keterampilan proses sains mahasiswa pendidikan fisika. Sementara disposisi mahasiswa setelah implementasi Project Based Learning berbasis potensi lokal pada perkuliahan fisika dasar tergolong pada tiga kategori yaitu sedang 50%, tinggi 37,5 % dan sangat tinggi 12,5%.
Optimal price and marketing policies with stock demand

This paper presents a model of optimal pricing and marketing policies in “stock demand” markets, such as the financial services industries, cell phones and mandatory “privatized” social security. In these markets the clientele with contracts evolves slowly. It is shown that in a perfect equilibrium, the unique optimal price path leads to a steady state where the effective price elasticity depends on the rate of depreciation of the clientele through exit, on the discount rate, and on the elasticity of both entry and exit flows to prices. A perfect symmetric equilibrium does not exist always, however. Under some parameter conditions there can be multiple asymmetric Nash equilibrium in marketing investment, which are more reasonable than the symmetric equilibrium because the latter does not meet a refinement we propose. The asymmetric equilibria lead to a war of attrittion and to mergers that concentrate the industry. It is shown that in the case of mandatory demand, for an important region of parameter values, only concentrated industry structures allow a perfect symmetric equilibrium to exist, while excessively atomistic structures encourage marketing wars and mergers.
Calcium-sensing receptor regulates stomatal closure through hydrogen peroxide and nitric oxide in response to extracellular calcium in Arabidopsis

The Arabidopsis calcium-sensing receptor CAS is a crucial regulator of extracellular calcium-induced stomatal closure. Free cytosolic Ca2+ (Ca2+i) increases in response to a high extracellular calcium (Ca2+o) level through a CAS signalling pathway and finally leads to stomatal closure. Multidisciplinary approaches including histochemical, pharmacological, fluorescent, electrochemical, and molecular biological methods were used to discuss the relationship of hydrogen peroxide (H2O2) and nitric oxide (NO) signalling in the CAS signalling pathway in guard cells in response to Ca2+o. Here it is shown that Ca2+o could induce H2O2 and NO production from guard cells but only H2O2 from chloroplasts, leading to stomatal closure. In addition, the CASas mutant, the atrbohD/F double mutant, and the Atnoa1 mutant were all insensitive to Ca2+o-stimulated stomatal closure, as well as H2O2 and NO elevation in the case of CASas. Furthermore, it was found that the antioxidant system might function as a mediator in Ca2+o and H2O2 signalling in guard cells. The results suggest a hypothetical model whereby Ca2+o induces H2O2 and NO accumulation in guard cells through the CAS signalling pathway, which further triggers Ca2+i transients and finally stomatal closure. The possible cross-talk of Ca2+o and abscisic acid signalling as well as the antioxidant system are discussed.