Miracle-dz/UniFAR-FTUs huggingface dataset:
EVALUATION OF ANTIFUNGAL ACTIVITY OF STREPTOMYCES PUNICEUS RHPR9 AGAINST MACROPHOMINA PHASEOLINA, CAUSATIVE AGENT OF CHARCOAL ROT DISEASE IN CHILLI (CAPSICUM ANNUUM L.)

A number of soil-borne fungi cause diseases in chilli crop that result in significant yield loss. Hence in the present study, S. puniceus RHPR9 was evaluated against soil borne pathogens such as Macrophomina phaseolina, Fusarium oxysporum, Phytophthora capsici and Sclerotium rolfsii. Strain RHPR9 was antagonistic to M. phaseolina (76±0.1%), F. oxysporum (62±0.1%), P. capsici (57±0.2%) and S. rolfsii (52±0.1%), with a severe inhibitory impact on fungal growth and development. Further evaluation against charcoal rot disease in chilli was done under greenhouse conditions and plant weight was recorded. In addition, enzymes (peroxidase (POX), polyphenol oxidase (PPO) and phenylalanine ammonia lyase (PAL)) responsible for induced resistance were characterized. It was observed that there was considerable increase of POX, PPO and PAL in chilli plants treated with S. puniceus when compared to control. This study elucidates that S. puniceus induced POX, PPO and PAL biosynthetic pathways and inhibited M. phaseolina and can be potential biocontrol agent.
SPECIFIC CHARACTERISTICS OF MENTAL STATUS IN PATIENTS WITH RHEUMATIC ARTHRITIS DEPENDING ON SEX

The work is devoted to the study the specific characteristics of mental status in patients with different variants of polymorphic regions of the A1438-G gene of the serotonin receptor 2A (HTR2A), ill with rheumatoid arthritis, depending on gender, and to study the relationship between anxiety-depressive disorders and pain intensity and clinical signs of the disease. Materials and мethods used in the study. The distribution of genotype rate of serotonin receptor 5-HT2A A1438-G gene was studied in 100 patients with RA. Anxiety level was assessed by Spielberger State-Trait Anxiety Scale. Depressive status and depression severity was evaluated by Hamilton Depression Rating Scale. Females with GG genotype were found to have higher level of pain feelings and the presence of anxiety signs associated with depression symptoms, while in males with GG genotype had the prevalence of inflammatory component and the depression symptoms.In females with AA genotype pain syndrome indices were associated with high anxiety indices, and in females with AG genotype they were dependent on the presence or absence of anxiety and depression, while in males with AG genotype pain syndrome was associated with SA indices.
A dedicated Fourier analysis for the simulation of composite pipes with defects

Through the study of a linear problem, this paper introduces some of the ingredients that are needed in order to conduct efficient non‐linear calculations on composite pipes under thermo‐mechanical loading in the presence of defects. Based on the observation that the main degradation scenarios take place at the extremity of a pipe, a refined model is used to describe this end zone while the rest of the pipe is described using a beam model. This study focuses on the efficient resolution of the refined end zone. For that, a dedicated Fourier expansion is used. The initial 3D problem is then transformed in a set of coupled 2D ones. The questions of the expansion truncation and the resolution of the coupled problem are then tackled. The use of a preconditioned conjugate gradient method allows to treat quasi‐industrial problems in a prototype code in Matlab. Copyright © 2006 John Wiley & Sons, Ltd.
Cellular Competitive Decision Algorithm for Minimum Ratio Spanning Tree

Minimum ratio spanning tree(MRST) is the problem of finding a minimum spanning tree when the objective function is the ratio of two linear cost functions(such as the ratio of cost to weight). MRST problem is NP-hard when the denominator is unrestricted in sign. Cellular Competitive decision algorithm(CCDA) is a newly proposed meta-heuristic algorithm for solving combinatorial optimization problems. In this paper, a cellular competitive decision algorithm for MRST is presented. To verify the efficiency of the algorithm, it is been coded in Delphi 7, by which series of instances are tested and results result in good performance.
The Influence of Everyday Acoustic Environments on the Challenging Behavior in Dementia: A Participatory Observation Study in Nursing Homes

Dementia is a progressive illness characterized by cognitive and functional decline and often co‐occurs with a behaviour change. ‘Challenging behaviour’ (CB) is a group of behaviours, reactions and symptoms due to dementia, which can be challenging for the (professional) caregivers. The study aims to research the influence of acoustic on CB in people with dementia (PwD).
Learning a rule in a multilayer neural network

The problem of learning from examples in multilayer networks is studied within the framework of statistical mechanics. Using the replica formalism we calculate the average generalization error of a fully connected committee machine in the limit of a large number of hidden units. If the number of training examples is proportional to the number of inputs in the network, the generalization error as a function of the training set size approaches a finite value. If the number of training examples is proportional to the number of weights in the network we find first-order phase transitions with a discontinuous drop in the generalization error for both binary and continuous weights.
Digital rock physics: 3D imaging of core material and correlations to acoustic and flow properties

3D X-ray microtomographic imaging and visualization of core material at the pore scale and subsequent analysis of petrophysical properties can give important insight to understanding properties of reservoir core material. 3D images allow one to map in detail the pore and grain structure and interconnectivity of core material. Numerical calculations on image data are in agreement with experimental data for flow and elastic properties on simple core material. This development forms the basis for developing more meaningful structure-property correlations in rock.
Effects of low-temperature stress on intestinal structure, enzyme activities and metabolomic analysis of juvenile golden pompano (Trachinotus ovatus)

Water temperature plays a crucial role in the growth, survival, and reproduction of fish species, as they make up the majority of aquatic fauna. In this study, the effects of low temperature were studied on the functional state of juvenile golden pompano (Trachinotus ovatus) under low-temperature stress. The study was conducted at 28°C in the control group and 18°C in the cold group for 14 d to determine the intestinal tissue, digestive and antioxidant enzyme activities, and metabolites of juvenile fish. The results showed that: (1) the swelling degree of the muscle layer deepened and was congested with a longer low-temperature stress period. The folds were sparse, from slight swelling to shedding and deformation. The intestinal mucosa was necrotic and had vacuoles, and the number gradually increased. Serious erosion of the villi occurred. (2) The specific activities of digestive enzymes showed a downward trend. (3) The intestinal superoxide dismutase (SOD) activity, malondialdehyde (MDA) content, and glutathione peroxidase (GSH-Px) activity showed an upward trend. The intestinal catalase (CAT) activity showed a downward trend. (4) Compared with the control group, there were 28 metabolites in the cold group showing significant differences, among which Z, 11Z, 14Z-eicosatrienoic acid, stearic acid, and adrenic acid showed an upward trend. In contrast, spermidine and uracil showed a downward trend. Among the enriched metabolic pathways, the main differential pathways were unsaturated fatty acid biosynthesis, fatty acid biosynthesis, linoleic acid metabolism, pyrimidine metabolism, and β-alanine metabolism. According to metabolomic analysis, under low-temperature stress, the fish body improved the synthesis of unsaturated fatty acids and saturated fatty acids to adapt to a low-temperature environment and consumed spermidine to improve its immune ability to clear the peroxide generated by the synthesis of unsaturated fatty acids in the body so that the cells were protected from oxidative damage. After 14 days, low-temperature stress affected metabolites and enzyme activity indices in juvenile golden pompano. Low-temperature stress causes changes in intestinal antioxidants and digestive enzymes and damage intestinal tissues. As a result of this exploration of how low temperatures affect the juvenile golden pompano, the foundation is laid for future studies, such as the molecular mechanisms of low-temperature adaptation in fish species.
Measurement of the translational and rotational velocities of a noncolloidal sphere rolling down a smooth inclined plane at low Reynolds number

The translational and rotational velocities of a sphere rolling down an inclined plane at low Reynolds number were measured as a function of the angle of inclination of the plane. Both 140 μm glass and 6350 μm diam acrylic particles were used. A theoretical model including the effects of particle surface roughness was developed, and is in quantitative agreement with the measurements. In addition, statistically significant velocity fluctuations were measured and are explained by variation in the coefficient of friction of the sphere. The disagreement between the measurements of Carty (B.S. thesis, Massachusetts Institute of Technology, 1957) and the theory of Goldman et al. [Chem. Eng. Sci. 22, 637 (1967)] is explained.
Asymmetries in the HD 141569 circumstellar disk

We present HST/STIS coronagraphic observations of the disk around HD 141569. The data, with a spatial resolution and signal to noise higher than those previously obtained with HST/NICMOS2 allow a more detailed insight in the system. They reveal a very structured system, in which two ring-like structures at distances $\simeq$200 and 325 AU from the star are the most prominent features. The region between 125 and 175 AU is clearly devoid of material. An arc-like structure is also detected at about 250 AU, as well as a diffuse extended emission, both on the North side of the disk. The system appears to be highly asymmetrical, both with respect to its major and minor axes. Surprisingly, the brightness asymmetry with respect to both axes in the inner and outer parts of the disk is reversed. Possible explanations to the asymmetries include anisotropic scattering and/or non axisymmetrical distribution of the dust within the system. It is shown that anisotropic scattering cannot alone be responsible for all observed asymmetries. It is concluded that HD 141569 disk is non axi-symmetrical. Eventhough no detailed modeling is given in this observational paper, it is probable that the sculpting and brightness properties of the disk are due to the gravitational perturbation of a massive body.
In-Hover Aerodynamic Analysis of a Small Rotor with a Thin Circular-Arc Airfoil and a Convex Structure at Low Reynolds Number

This study focused on the in-hover aerodynamics of a small rotor with a thin circular-arc airfoil and a convex structure at a low Reynolds number. The method combined computational fluid dynamics (CFD) with the blade element momentum theory (BEMT). The former was used for studying the two-dimensional parametric aerodynamics of the airfoil at a low Reynolds number and the latter was used for the prediction of the rotor’s hover performance. A novel thin circular-arc airfoil with a convex structure with a high aerodynamic performance, high structural strength, light weight and easy manufacturing process is presented in this paper. A convex curve on the upper surface was adopted to increase the thickness of the airfoil at partial chord, and a stiffener in the airfoil was installed to improve the structural strength of rotor span-wise. The aerodynamic performance of the airfoil was numerically simulated by the two-dimensional steady and incompressible Navier–Stokes equations. The in-hover performance of the rotor for small-scale vehicles was predicted by an improved version of the blade element momentum theory (BEMT). Finally, a carbon-fiber rotor with the presented airfoil was manufactured that had a diameter of 40 cm and a pitch of 6.2 inches. The analysis results were verified by experiments. It was shown that the maximum calculation errors were below 6%. The improved BEMT can be used in the analysis of in-hover micro-rotor aerodynamics at low Reynolds numbers.
Molecular design method based on novel molecular representation and variational auto-encoder

Based on the traditional VAE, a novel neural network model is presented, with the latest molecular representation, SELFIES, to improve the effect of generating new molecules. In this model, multi-layer convolutional network and Fisher information are added to the original encoding layer to learn the data characteristics and guide the encoding process, which makes the features of the data hiding layer more aggregated, and integrates the Long Short Term Memory neural network (LSTM) into the decoding layer for better data generation, which effectively solves the degradation phenomenon generated by the encoding layer and decoding layer of the original VAE model. Through experiments on zinc molecular data sets, it is found that the similarity in the new VAE is 8.47% higher than that of the original ones. SELFIES are better at generating a variety of molecules than the traditional molecular representation, SELFIES. Experiments have shown that using SELFIES and the new VAE model presented in this paper can improve the effectiveness of generating new molecules.
Amplifying the efficacy of ALA-based prodrugs for photodynamic therapy using nanotechnology

5-aminolevulinic acid (ALA) is a clinically approved prodrug involved in intracellular Heme biosynthesis to produce the natural photosensitizer (PS) Protoporphyrin IX (PpIX). ALA based photodynamic therapy (PDT) has been used to treat various malignant and non-malignant diseases. However, natural ALA has disadvantages such as weak lipophilicity, low stability and poor bioavailability, greatly reducing its clinical performance. The emerging nanotechnology is expected to address these limitations and thus improve the therapeutic outcomes. Herein, we summarized important recent advances in the design of ALA-based prodrugs using nanotechnology to improve the efficacy of PDT. The potential limitations and future perspectives of ALA-based nanomedicines are also briefly presented and discussed.
Myrtinols A–F: New Anti-Inflammatory Peltogynoid Flavonoid Derivatives from the Leaves of Australian Indigenous Plant Backhousia myrtifolia

Our in-house ethnopharmacological knowledge directed our anti-inflammatory investigation into the leaves of Backhousia mytifolia. Bioassay guided isolation of the Australian indigenous plant Backhousia myrtifolia led to the isolation of six new rare peltogynoid derivatives named myrtinols A–F (1–6) along with three known compounds 4-O-methylcedrusin (7), 7-O-methylcedrusin (8) and 8-demethylsideroxylin (9). The chemical structures of all the compounds were elucidated by detailed spectroscopic data analysis, and absolute configuration was established using X-ray crystallography analysis. All compounds were evaluated for their anti-inflammatory activity by assessing the inhibition of nitric oxide (NO) production and tumor necrosis factor- α (TNF-α) in lipopolysaccharide (LPS) and interferon (IFN)-γ activated RAW 264.7 macrophages. A structure activity relationship was also established between compounds (1–6), noting promising anti-inflammatory potential by compounds 5 and 9 with an IC50 value of 8.51 ± 0.47 and 8.30 ± 0.96 µg/mL for NO inhibition and 17.21 ± 0.22 and 46.79 ± 5.87 µg/mL for TNF-α inhibition, respectively.
Standing-wave excited photoemission experiments on Si/MoSi2 multilayer mirrors in the soft x-ray regime: An analytical modeling approach

Photoemission experiments were performed on Si/MoSi2 multilayers using soft x-ray standing waves for excitation. The combination of photoemission spectroscopy and standing-wave excitation results in a depth profile of the sample that is also sensitive to chemical states. The experimental data were analyzed using an approximate analytical, rather than a full numerical, method in order to more quickly yield results, as well as to calibrate and better understand the method. The important parameters in the resulting equations are discussed in detail. Thus, we quickly obtain access to the key parameters modulating the photoelectron intensity excited by x-ray standing waves. We demonstrate the analytical approach on a simple experimental test data set.
Identification of Antioxidative Peptides Derived from Arthrospira maxima in the Biorefinery Process after Extraction of C-Phycocyanin and Lipids

Arthrospira maxima has been identified as a sustainable source of rich proteins with diverse functionalities and bioactivities. After extracting C-phycocyanin (C-PC) and lipids in a biorefinery process, the spent biomass still contains a large proportion of proteins with potential for biopeptide production. In this study, the residue was digested using Papain, Alcalase, Trypsin, Protamex 1.6, and Alcalase 2.4 L at different time intervals. The resulting hydrolyzed product with the highest antioxidative activity, evaluated through their scavenging capability of hydroxyl radicals, superoxide anion, 2,2-diphenyl-1-picrylhydrazyl (DPPH), and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS), was selected for further fractionation and purification to isolate and identify biopeptides. Alcalase 2.4 L was found to produce the highest antioxidative hydrolysate product after four-hour hydrolysis. Fractionating this bioactive product using ultrafiltration obtained two fractions with different molecular weights (MW) and antioxidative activity. The low-molecular-weight fraction (LMWF) with MW <3 kDa had higher DPPH scavenging activity with the IC50 value of 2.97 ± 0.33 compared to 3.76 ± 0.15 mg/mL of the high-molecular-weight fraction (HMWF) with MW >3 kDa. Two stronger antioxidative fractions (F-A and F-B) with the respective significant lower IC50 values of 0.83 ± 0.22 and 1.52 ± 0.29 mg/mL were isolated from the LMWF using gel filtration with a Sephadex G-25 column. Based on LC-MS/MS analysis of the F-A, 230 peptides derived from 108 A. maxima proteins were determined. Notably, different antioxidative peptides possessing various bioactivities, including antioxidation, were detected with high predicted scores together with in silico analyses on their stability and toxicity. This study established knowledge and technology to further value-add to the spent A. maxima biomass by optimizing hydrolysis and fraction processes to produce antioxidative peptides with Alcalase 2.4 L after two products already produced in a biorefinery. These bioactive peptides have potential applications in food and nutraceutical products.
Implementation and Evaluation of Telehaptics over Long Term Evolution (4G) - Towards 5G Powered Telesurgery

In teleoperation systems, visual, audio, and haptic feedback are essential to understand operating conditions in a remote environment fully. Despite the success in the integration of visual and audio feedback into teleoperation systems, the incorporation of haptic feedback has been a challenge. This is mainly because the existing traditional network technologies and infrastructure do not meet these systems' stringent performance requirements, which include transmission delay of less than 10ms and network reliability greater than 99.99%. Such requirements are defined for the 5G ultra-reliable and low-latency communications service domain. However, despite the commercial deployment of 5G networks in developed countries, such as China, Canada, and Germany, network coverage in most developing countries is still 2G and 3G, with 4G limited to high-income areas. Therefore, optimising the performance of existing network infrastructures is necessary to meet the performance requirements of various mission-critical applications, such as haptic-enabled telesurgery, that will help increase access to specialized healthcare services in rural remote and underserved areas. This work presents a proof-of-concept design, implementation, and evaluation of a telehaptics system on a low-latency optimized 4G-based digital health network testbed. The Quality of Service parameters of reliability, end-to-end delay, and throughput is evaluated. The evaluation results revealed a minimum round trip transmission time of 14 ms over the 4G network, compared to the maximum delay acceptable for haptic-enabled telesurgery systems of 10 ms. Future work will include testing the system on 5G standalone and non-standalone testbed implementations.
Lignin-Loaded Carbon Nanoparticles as a Promising Control Agent against Fusarium verticillioides in Maize: Physiological and Biochemical Analyses

Lignin, a naturally occurring biopolymer, is produced primarily as a waste product by the pulp and paper industries and burned to produce electricity. Lignin-based nano- and microcarriers found in plants are promising biodegradable drug delivery platforms. Here, we highlight a few characteristics of a potential antifungal nanocomposite consisting of carbon nanoparticles (C-NPs) with a defined size and shape containing lignin nanoparticles (L-NPs). Spectroscopic and microscopic studies verified that the lignin-loaded carbon nanoparticles (L-CNPs) were successfully prepared. Under in vitro and in vivo conditions, the antifungal activity of L-CNPs at various doses was effectively tested against a wild strain of F. verticillioides that causes maize stalk rot disease. In comparison to the commercial fungicide, Ridomil Gold SL (2%), L-CNPs introduced beneficial effects in the earliest stages of maize development (seed germination and radicle length). Additionally, L-CNP treatments promoted positive effects on maize seedlings, with a significant increment in the level of carotenoid, anthocyanin, and chlorophyll pigments for particular treatments. Finally, the soluble protein content displayed a favorable trend in response to particular dosages. Most importantly, treatments with L-CNPs at 100 and 500 mg/L significantly reduced stalk rot disease by 86% and 81%, respectively, compared to treatments with the chemical fungicide, which reduced the disease by 79%. These consequences are substantial considering the essential cellular function carried out by these special natural-based compounds. Finally, the intravenous L-CNPs treatments in both male and female mice that affected the clinical applications and toxicological assessments are explained. The results of this study suggest that L-CNPs are of high interest as biodegradable delivery vehicles and can be used to stimulate favorable biological responses in maize when administered in the recommended dosages, contributing to the idea of agro-nanotechnology by demonstrating their unique qualities as a cost-effective alternative compared to conventional commercial fungicides and environmentally benign nanopesticides for long-term plant protection.