Miracle-dz/UniFAR-FTUs huggingface dataset:
Sparc (Osteonectin): new insight into the function and regulation = Sparc (Osteonectin): nuevos conocimientos sobre sus funciones y regulación

Osteonectina, tambien llamada Sparc o BM-40, es una glicoproteina multifuncional que pertenece a la familia de las proteinas matricelulares de la matriz extracelular. Este grupo modula las interacciones entre la matriz y las celulas e interviene en multiples funciones mas que jugar un papel en la estructura celular. Se sabe que Sparc tiene una alta afinidad por los iones calcio y fue descubierta por primera vez como el componente mayoritario de la matriz extracelular de tejidos mineralizados. Mas tarde, se localizo Sparc en muchos otros tejidos. La expresion de Sparc es alta durante el desarrollo temprano y disminuye durante la edad adulta. Sin embargo, su expresion aumenta en tejidos que requieren cierto grado de renovacion, reparacion o en tumorigenesis. Debido a que Sparc es capaz de interactuar con multiples moleculas, se le han atribuido importantes funciones como antiadhesion, regulacion del ciclo celular y actividad angiogenica. Debido al poco conocimiento respecto a la regulacion de Sparc y los papeles contradictorios en diferentes tejidos, el objetivo principal de esta tesis es contribuir a un mayor entendimiento de este gen en peces teleosteos. En esta tesis demostramos: 1. Sparc es un regulador importante en hematopoyesis embriogenica durante el desarrollo temprano del pez cebra. 2. Localizamos sparc corriente abajo de fgf21 en esta cascada de regulacion. 3. La radiacion ultravioleta es capaz de inducir un incremento en la expresion de p53 y Sparc. 4. Dado que sparc esta altamente expresada en embriones expuestos a radiacion ultravioleta, este gen puede estar implicado en el incremento de malformaciones durante el desarrollo. Asi, se sugiere que posiblemente sparc sea capa de inducir un mecanismo molecular en respuesta a la exposicion de UV. 5. El intron localizado entre las dos regiones 5? UTR es clave para regulacion transcripcional de sparc ya que el vector conteniendo unicamente esta secuencia asociada a GFP es capaz de expresar fluorescencia en notocorda, ICM, vesicula otica, bulbo olfatorio y fibras musculares, lugares donde se sabe que sparc esta presente tanto en pez cebra como en otras especies de teleosteos. 6. Sparc esta regulada a nivel de la transcripcion por metilacion del ADN. Concretamente, la isla CpG detectada en el intron es susceptible a procesos de metilacion. 7. Tanto la secuencia aminoacidica de Sparc como los lugares de expresion en larvas de rodaballo (Scophthalmus maximus) estan altamente conservados cuando se comparan con las secuencias existentes en otras especies. 8. Sparc tiene un papel durante la metamorfosis de rodaballo por su alta expresion en etapas premetamorficas.
Title of Deliverable : Report on IPv 6 QoS tests Work package contributing to Deliverable : WP 4 Type of Deliverable

This document mainly presents the first phase QoS tests performed in 6NET. Most of the partners analysed the operation and interaction of QoS mechanisms, e.g. shaping or queuing, in IPv6 testbeds or production networks and validated the performance of QoS implementations for different platforms. Finally, the last section presents the second phase of QoS tests that are planned to be performed in 6NET and describes the different Class of Services that will be supported at the core.
p27 Kip1 and ser10-phosphorylated p27 Kip1 in breast cancer: clinical significance and expression

Background: The protein p27 (p27 Kip1 ) is a member of the cyclin-dependent kinase inhibitor family, which negatively regulates cell cycle progression, and the phosphorylation of p27 has been proven to affect its stability and nuclear export. Clinical studies on the relation between p27 and phosphorylated p27 (p-p27Ser10) in breast invasive ductal carcinomas are still scarce. Methods: We examined the expression of p27 and p-p27Ser10 using immunohistochemistry in 107 breast invasive ductal carcinomas and analyzed the relationship of these biomarkers and tumor characteristics. Results: Of the 107 tumor samples, 38.3% (41 of 107) overexpressed p27 and 64.5% (69 of 107) overexpressed p-p27Ser10. Analysis of correlation with clinical characteristics showed that high expression level of p-p27Ser10 was linked to poor differentiation, advanced disease stage, and lymph node metastasis, whereas a contrary trend was observed for p27 (all P , 0.05). In addition, the expression of p-p27Ser10 was significantly higher in malignant tumors than in adjacent tissues, while p27 showed the opposite trend. Also, there were different levels of p27 and p-p27Ser10 in different types of breast cancer. Conclusion: p27 and p-p27Ser10 are involved in the development of invasive ductal carcinoma and are potential indicators to judge the degree of malignancy as well as recurrence and metastasis.
Detection of fast-(cid:13)ux botnets through DNS tra(cid:14)c analysis

Botnets are networks built up of a large number of bot computers, which provide the attacker with massive resources, such as bandwidth, storage, and processing power, in turn, allowing the attacker to launch massive attacks, such as Distributed Denial of Service (DDoS) attacks, or undertake spamming or phishing campaigns. One of the main approaches for botnet detection is based on monitoring and analyzing DNS query/responses in the network, where botnets make their detection more di(cid:14)cult by using techniques such as fast-(cid:13)uxing. Moreover, the main challenge in detecting fast-(cid:13)ux botnets arises from their similar behavior with that of legitimate networks, such as CDNs, which employ a round-robin DNS technique. In this paper, we propose a new system to detect fast-(cid:13)ux botnets by passive DNS monitoring. The proposed system (cid:12)rst (cid:12)lters out domains seen in historical DNS traces assuming that they are benign. We believe this assumption to be valid as benign domains usually have long lifetime as compared to botnet domains, which are usually short-lived. Hence, CDN domains, which are the main cause of misclassi(cid:12)cation when looking for malicious fast-(cid:13)ux domains, are removed. Afterwards, a few simple features are calculated to help in properly categorizing the domains in question as either benign or botnet related. proposed system is evaluated by employing DNS traces from our campus network and encouraging evaluation results are obtained. ' 2015 Sharif University of Technology. All rights reserved.
AIDS Care : Psychological and Socio-medical Aspects of AIDS / HIV

HIV economic burden of illness in the Veterans Health Administration population Li Wang, Seema Haider, Katherine Nedrow, Richard Chambers, Margaret Tawadrous, Onur Baser & Kit N. Simpson a Analytic Research, STATinMED Research, Plano, TX, USA b Global Established Pharma Business, Outcomes and Evidence, Pfizer, Inc., New York, NY, USA c Infectious Disease, Global Outcomes Research, Pfizer Inc., Groton, CT, USA d Global Established Pharma Business, Clinical Affairs, Pfizer, Inc., Groton, CT, USA e Department of Internal Medicine, The University of Michigan and Health Economics and Outcomes Research, STATinMED Research, Ann Arbor, MI, USA f Department of Health Leadership and Management, College of Health Professions, Medical University of South Carolina, Charleston, SC, USA Published online: 16 Sep 2014.
AIDS Care : Psychological and Socio-medical Aspects of AIDS / HIV

Rapid psychosocial function screening test identified treatment failure in HIV+ African youth Elizabeth Lowenthal a b c , Kathy Lawler c d , Nurit Harari c e , Lesedi Moamogwe c , Japhter Masunge f g , Motshodi Masedi h , Bolefela Matome g , Esther Seloilwe i & Robert Gross c j a General Pediatrics , Children's Hospital of Philadelphia , Philadelphia , PA , USA b Department of Pediatrics , University of Pennsylvania , Philadelphia , PA , USA c Botswana-Upenn Partnership , Gaborone , Botswana d Department of Neurology , University of Pennsylvania , Philadelphia , PA , USA e Robert Wood Johnson Foundation Clinical Scholars Program , Yale University School of Medicine , New Haven , CT , USA f School of Medicine , University of Botswana , Gaborone , Botswana g Nyangabgwe Hospital , Francistown , Botswana h Letsholathebe Hospital , Maun , Botswana i Department of Nursing Education , University of Botswana , Gaborone , Botswana j Department of Medicine (Infectious Diseases and Epidemiology) , University of Pennsylvania , Philadelphia , PA Published online: 31 Jan 2012.
AIDS Care : Psychological and Socio-medical Aspects of AIDS / HIV

African immigrant views of HIV service needs: Gendered perspectives Catherine Worthington a , David Este b , Keri-Lynn Strain c & Nedra Huffey b a School of Public Health and Social Policy , University of Victoria , Victoria , British Columbia , Canada b Faculty of Social Work , University of Calgary , Calgary , Alberta , Canada c Faculty of Medicine , University of Calgary , Calgary , Alberta , Canada Published online: 06 Jun 2012.
The Equity Premium Implied by Production Urban

This paper studies the determinants of the equity premium as implied by producers’ firstorder conditions. A closed form expression is presented for the Sharpe ratio at steady-state as a function of investment volatility and adjustment cost curvature. Calibrated to the U.S. postwar economy, the model can generate a sizeable equity premium, with reasonable volatility for market returns and risk free rates. The market’s Sharpe ratio and the market price of risk are very volatile. Contrary to most models, the model generates a negative correlation between conditional means and standard deviations of aggregate excess returns. (
The Equity Premium : Why Is It a Puzzle ?

This article takes a critical look at the equity premium puzzle—the inability of standard intertemporal economic models to rationalize the statistics that have characterized U.S. financial markets over the past century. A summary of historical returns for the United States and other industrialized countries and an overview of the economic construct itself are provided. The intuition behind the discrepancy between model prediction and empirical data is explained. After detailing the research efforts to enhance the model’s ability to replicate the empirical data, I argue that the proposed resolutions fail along crucial dimensions.
USENIX Association Proceedings of the Third USENIX Conference on File and Storage Technologies

Row-Diagonal Parity (RDP) is a new algorithm for protecting against double disk failures. It stores all data unencoded, and uses only exclusive-or operations to compute parity. RDP is provably optimal in computational complexity, both during construction and reconstruction. Like other algorithms, it is optimal in the amount of redundant information stored and accessed. RDP works within a single stripe of blocks of sizes normally used by file systems, databases and disk arrays. It can be utilized in a fixed (RAID-4) or rotated (RAID-5) parity placement style. It is possible to extend the algorithm to encompass multiple RAID-4 or RAID-5 disk arrays in a single RDP disk array. It is possible to add disks to an existing RDP array without recalculating parity or moving data. Implementation results show that RDP performance can be made nearly equal to single parity RAID-4 and RAID-5 performance.
MEMS-based Storage Devices and Standard Disk Interfaces: A Square Peg in a Round Hole?

MEMS-based storage devices (MEMStores) are significantly different from both disk drives and semiconductor memories. The differences motivate the question of whether they need new abstractions to be utilized by systems, or if existing abstractions will be sufficient. This paper addresses this question by examining the fundamental reasons that the abstraction works for existing devices, and by showing that these reasons also hold for MEMStores. This result is shown to hold through several case studies of proposed roles MEMStores may take in future systems and potential policies that may be used to tailor systems' access to MEMStores. With one noted exception, today's storage interfaces and abstractions are as suitable for MEMStores as for disks.
Validation of the Cosmed Fitmate for Prediction of Maximal Oxygen Consumption

Lee, J-M, Bassett Jr, DR, Thompson, DL, and Fitzhugh, EC. Validation of the Cosmed Fitmate for prediction of maximal oxygen consumption. J Strength Cond Res 25(9): 2573-2579, 2011—The main purpose of this study was to assess the validity of the Cosmed Fitmate (FM) for the prediction of maximal oxygen consumption (&OV0312;o2max). In addition, this study examined whether measuring submaximal &OV0312;o2, rather than predicting it, can improve upon the prediction of &OV0312;o2max. Participants for the study were 48 young to middle-age adults (32 men, 16 women), with a mean age of 31 yr. Each participant completed a submaximal and maximal treadmill test on 2 separate occasions. During the submaximal test, &OV0312;o2max was predicted using the FM. This device extrapolates the linear regression relating heart rate (HR) and measured &OV0312;o2 at submaximal work rates to age-predicted maximum HR (HR = 220 − age). The criterion measure was obtained using a graded, maximal treadmill test, with &OV0312;o2 measured by the Douglas bag (DB) method. There was no significant difference between &OV0312;o2max predicted by the FM and &OV0312;o2max measured by the DB method. The results of this study showed that a strong positive correlation (r = 0.897) existed between &OV0312;o2max predicted by the FM and &OV0312;o2max measured by the DB method, with a standard error of the estimate (SEE) = 3.97 ml·kg−1·min−1. There was a significant difference in &OV0312;o2max predicted by the American College of Sports Medicine (ACSM) metabolic equations and &OV0312;o2max measured by the DB method (p = 0.01). The correlation between these variables was r = 0.758 (SEE = 5.26 ml·kg−1·min−1). These findings indicate that a small, portable, and easy-to-use metabolic system provides valid estimates of &OV0312;o2max, and improves upon predictive accuracy, compared to using generalized ACSM metabolic equations.
Search for WZ resonances in the fully leptonic channel using pp collisions at √ s = 8 TeV with the ATLAS detector

Article history: Received 17 June 2014 Received in revised form 30 July 2014 Accepted 15 August 2014 Available online 20 August 2014 Editor: W. -D. Schlatter A search for resonant WZ production in the ν ′ ′ ( , ′ = e, μ) decay channel using 20.3 fb−1 of √s = 8 TeV pp collision data collected by the ATLAS experiment at LHC is presented. No significant deviation from the Standard Model prediction is observed and upper limits on the production cross sections of WZ resonances from an extended gauge model W ′ and from a simplified model of heavy vector triplets are derived. A corresponding observed (expected) lower mass limit of 1.52 (1.49) TeV is derived for the W ′ at the 95% confidence level. © 2014 CERN for the benefit of the ATLAS Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/). Funded by SCOAP3.
Psychosocial factors involved in memory and cognitive failures in people with myalgic encephalomyelitis/chronic fatigue syndrome

Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by persistent emotional, mental, and physical fatigue accompanied by a range of neurological, autonomic, neuroendocrine, immune, and sleep problems. Research has shown that psychosocial factors such as anxiety and depression as well as the symptoms of the illness, have a significant impact on the quality of life of people with ME/CFS. In addition, individuals may suffer from deficits in memory and concentration. This study set out to explore the relationships between variables which have been found to contribute to cognitive performance, as measured by prospective and retrospective memory, and cognitive failures. Methods: Eighty-seven people with ME/CFS answered questionnaires measuring fatigue, depression, anxiety, social support, and general self-efficacy. These were used in a correlational design (multiple regression) to predict cognitive function (self-ratings on prospective and retrospective memory), and cognitive failures. Results: Our study found that fatigue, depression, and general self-efficacy were directly associated with cognitive failures and retrospective (but not prospective) memory. Conclusion: Although it was not possible in this study to determine the cause of the deficits, the literature in this area leads us to suggest that although the pathophysiological mechanisms of ME/CFS are unclear, abnormalities in the immune system, including proinflammatory cytokines, can lead to significant impairments in cognition. We suggest that fatigue and depression may be a result of the neurobiological effects of ME/CFS and in addition, that the neurobiological effects of the illness may give rise to both fatigue and cognitive deficits independently.
Atoms in the lowest motional band of a three-dimensional optical lattice

We investigate the storage of atoms in an optical lattice, using light detuned up to 2nm to the blue of an atomic transition. Argon atoms were laser cooled in the metastable state 1s{sub 5}(J=2) and optically pumped to the state 1s{sub 3}(J=0). Subsequently these atoms were confined to the nodes of a three-dimensional interference pattern and stored for up to 1s. We resolved the bands of motion in the lattice using a time-of-flight technique, and observed band-dependent losses leading to the preparation of atoms in the motional ground band. {copyright} {ital 1997} {ital The American Physical Society}
A search for an unexpected asymmetry in the production of e + μ − and e − μ + pairs in proton–proton collisions recorded by the ATLAS detector at √ s = 13 TeV

This search, a type not previously performed at ATLAS, uses a comparison of the production cross sections for e + μ − and e − μ + pairs to constrain physics processes beyond the Standard Model. It uses 139 fb − 1 of proton–proton collision data recorded at √ s = 13TeV at the LHC. Targeting sources of new physics which prefer ﬁnal states containing e + μ − to e − μ + , the search contains two broad signal regions which are used to provide model-independent constraints on the ratio of cross sections at the 2% level. The search also has two special selections targeting supersymmetric models and leptoquark signatures. Observations using one of these selections are able to exclude, at 95% conﬁdence level, singly produced smuons with masses up to 640GeV in a model in which the only other light sparticle is a neutralino when the R -parity-violating coupling λ (cid:3) 231 is close to unity. Observations using the other selection exclude scalar leptoquarks with masses below 1880GeV when g eu 1R = g μ c 1R = 1, at 95% conﬁdence level. The limit on the coupling reduces to g eu 1R = g μ c 1R = 0 . 46 for a mass of 1420GeV.
The economics of pandemics: Cyclical effects and recovery strategies of state manufacturing consumption in facing the COVID-19 pandemic in México

With the purpose of contributing to a better comprehension regarding the recovery of the Mexican economy during the COVID 19 pandemics, the objective of this investigation consists in identifying the differences between the strategies of economic adaptation to upgrows and contractions in state’s manufacturing sales associated to variations in COVID 19 contagions. Our results, obtained my means of a two-stage methodology, indicate 11 states applied precautionary strategies, 14 states adopted less precautionary strategies, and at least 18 states were effective in implementing a strategy of recovery
Statistical processing the results of interlaboratory testing the grain-size distribution of sand and gravel from the western part of the Kostolac basin

This paper presents the results of interlaboratory testing the grain-size distribution of sand and gravel on representative samples from the site of the western part of the Kostolac Basin. The results were statistically processed by two ways: Numerical method: the Cochran test of accuracy and Graphic interpretation: the MANDEL technique of consistency in accordance with the Standard SRPS ISO 5725-2 [1,2]. The followings were calculated: repeatability variance Sr2; interlaboratory variance SL 2 and reproducibility variance SR 2. Samples were submitted by sharing method to all participating laboratories.
ACR Appropriateness Criteria ® Imaging After Total Hip Arthroplasty EVIDENCE TABLE

* See Last Page for Key 2015 Review Weissman/Palestro Page 1 Reference Study Type Patients/ Events Study Objective (Purpose of Study) Study Results Study Quality 1. Lee K, Goodman SB. Current state and future of joint replacements in the hip and knee. Expert Rev Med Devices. 2008;5(3):383-393. Review/OtherDx N/A Review current state and future of joint replacement in the hip and knee. Potential advancements in arthroplasty surgery include new, more wear-resistant bearing surfaces, porous metals to enhance osseointegration and replace lost bone stock, a clearer understanding of the biological processes associated with periprosthetic osteolysis, minimally invasive surgery and computer assisted surgery. Long-term studies are needed to establish the efficacy of these new technologies. 4
The Impacts of Tolling on Low-income Persons in the Puget Sound Region

To improve the understanding of how tolling is likely to affect low-income populations in the Puget Sound region, this report accomplishes four objectives. It (1) reviews existing research on the impacts of tolling on low-income households in the United States; (2) assesses the usefulness of currently available Washington and Puget Sound data for estimating the impacts of tolling on low-income populations; (3) develops a preliminary estimate of the impacts of tolling on low-income populations living in the Puget Sound region; and (4) suggests data collection and methodological strategies for future research that would yield better estimates of the impacts of tolling on low-income populations in the Puget Sound region and other parts of Washington state.
Radiocarbon and Stratigraphic Chronology of Canímar Abajo, Matanzas, Cuba

Twelve accelerator mass spectrometry (AMS) radiocarbon dates from the shell-matrix site of Canímar Abajo (Matanzas, Cuba) are reported. Eleven were obtained directly from human bone collagen in burials and one was obtained from charcoal recovered from a burial context. The site stratigraphy presents two episodes of burial activity separated by a shell midden layer. The AMS dates fall into two compact clusters that correlate remarkably well with the stratigraphy. The older burial dates to between 1380–800 cal BC (2σ) and the younger one to between cal AD 360–950 (2σ). The AMS dates are compared to eight conventional 14C dates previously obtained on shell and charcoal. One of the conventional dates on charcoal (5480–5380 cal BC; 2σ) has been reported as the oldest 14C date in the Caribbean region; its context and reliability are clarified. The suite of AMS dates provides one of the most reliable chronometric dating of a cultural context during this timeframe in Cuba. The correlation of 14C and stratigraphy establishes a solid chronology for investigating the important economic and ritual features of Canímar Abajo.