Miracle-dz/UniFAR-FTUs huggingface dataset:
Running head : PICU SAFETY CHECKLIST 1 Implementation of a Daily Checklist to Improve Patient Safety and Quality of Care in a Pediatric Intensive Care Unit

Background Multiple industries have demonstrated checklists to be of great value in reducing errors of omission and improving communication. In healthcare, checklists have been shown to ensure patients receive evidence-based, safe care. In a fast paced environment of a critical care unit, adverse events are common and can have significant consequences on patient outcome. Safety guardrails are necessary to minimize naturally occurring human error. Safety checklists help support best practices to standardize care and support processes to improve outcome. Objectives To develop and implement a daily safety checklist in a pediatric intensive care unit (PICU) to enhance clinical care and improve patient outcome. Methods After an extensive review of the literature, a multidisciplinary team was created to determine the structure and content for the checklist then placed on an electronic device. The setting of a 30-bed pediatric intensive care unit (PICU) in an urban academic institution was chosen. The PICU nurse practitioner team was identified as the data collection team. Pre and post-implementation surveys regarding perceptions of benefit of the checklist were administered to the data collection team. Results A total of 447 checklists were completed in thirty days. Data was successfully captured, and a reporting system was established. Results of the checklist were communicated with the multidisciplinary team daily. Surveyed practitioners reported an improved perception of the benefits of the checklist including improved team Running head: PICU SAFETY CHECKLIST 3 communication, improved outcomes, identification of safety issues, and the importance of the role in safety after implementation. Conclusion The use of a daily safety checklist in a pediatric critical care unit has the potential to enhance clinical care and improve patient outcome. Multidisciplinary communication, enhanced awareness of safety, and improved team perception of value can be improved from collaborative efforts to improve safety in a high paced critical care environment. Running head: PICU SAFETY CHECKLIST 4
The effect of cortisol on the excitability of the rat muscle fibre membrane and neuromuscular transmission.

The present experiments show that cortisol when applied in vitro, exerted two different effects on the electrical excitability of the diaphragm muscle fibre membrane and on the neuromuscular transmission depending on the concentration used. At low concentrations (2.5X10(-6) mol.l-1) it potentiated action potentials, increased resting membrane polarization by 3--4 mV and did not affect neuromuscular transmission. Higher concentrations (10(-2) mol.l-1) suppressed the action potential to a certain extent, depolarized the muscle fibre membrane by 6 mV and reduced the amplitudes of m.e.p.p.s and e.p.p.s as well as those of iontophoretically evoked acetylcholine potentials. It was concluded that the effect of low concentrations of cortisol is primary and is probably due to the enhancement of resting membrane permeability for K+ ions and to the changes in ion channels. Cortisol in high doses increased muscle oxygen consumption, so that its suppressing effect might be due to inhibition of energy metabolism.
Ephrin stimulation modulates T cell chemotaxis

Eph receptor tyrosine kinases and their ligands, the ephrins, are known to play an important role in regulating cell migration and targeting in neuronal and endothelial cells. Recently, it hasbeen shown that lymphoid cells also express Eph receptors, raising the possibility that Eph receptors may similarly regulate lymphocyte migration. Chemotaxis in response to soluble chemokine factors is an essential facet of T cell biology. We demonstrate here that T cell chemotaxis in response to both the stromal cell‐derived factor (SDF)‐1α and macrophage inflammatory protein 3β chemokines is modulated by costimulation with ephrins. Both ephrin‐A and ephrin‐B ligands were found to modify the chemotactic responses of a T cell line and primary T cells. Ephrin‐A1, in particular, strongly inhibited chemotaxis. In accordance with the tyrosine kinase activity of EphA receptors, ephrin‐A1 stimulation induced rapid intracellular tyrosine phosphorylation in T cells. Although strongly inhibiting chemotaxis, ephrin‐A1 costimulus did not affect many of the signaling events downstream of the SDF‐1α receptor CXCR4, including calcium flux and activation of MAPK. Rather, ephrin‐A1 altered the balance of small G protein activity in T cells. Ephrin‐A1 stimulation prevented SDF‐1α–induced activation of cdc42, while simultaneously inducing rho activation. Ultimately, ephrin‐A1 was found to inhibit chemokine‐induced actin polymerization, thereby blocking migration. Ubiquitous ephrin expression in vivo creates enormous potential for T cells to encounter these ligands, suggesting that Eph receptors and ephrins may be important regulators of T cell migration.
LTE user plane congestion detection and analysis

In Long Term Evolution (LTE) systems both radio and transport congestion might occur due to the increasing data traffic generated by smart devices accessing popular Internet applications. Packets arriving at a congested resource experience increased delay, random discards and eventually tail drops as a consequence of network side buffer overflows. The LTE system delegates congestion management to the end-to-end protocols such as the Transmission Control Protocol (TCP), which is not an efficient solution in mobile systems. Reduced TCP transmission rate and significant degradations such as retransmission timeouts (RTO) are commonly present upon congestion. Therefore, instead of relying only on the congestion management capabilities of the TCP, efficient network side mechanisms are needed to achieve harmonic system operation and prevent unnecessary TCP degradations. This was recognized by 3GPP resulting in the specification of the User Plane Congestion management (UPCON) framework. Nevertheless, the real time congestion detection and management mechanisms are not in the scope of UPCON. As the prerequisite of any efficient congestion management technique is the capability of accurate congestion detection, this paper provides a survey of the existing solutions, analyses their shortcomings and proposes a congestion detection method that correlates the delay skewness and the pattern of burst losses collected by user traffic monitoring. The method is presented via measurements from an LTE lab network.
Sector Biased Technical Change and Perpetual Structural Change

We construct a two-sector growth model to show that sector biased technical change is the only fundamental driving force of perpetual structural change and non-balanced sectoral growth. The direction of sector biased technical change depends exclusively on the sectoral difference in the purely labor augmenting technical change rates. And the endogenous sectoral difference in the purely labor augmenting technical change rates depends on not only the elasticity of substitution between two intermediate good sectors but also the sectoral difference in the products of the labor intensity and one minus the degree of R&D spillover effects within the same sector.
Near-optimal SLAM exploration in Gaussian processes

In this paper we examine near-optimal SLAM exploration in Gaussian processes. We propose a submodular sensing quality function that extends studies from discrete sensor placement to an autonomous sampling scheme where sensing sites must be visited frequently. This is beneficial in the SLAM context, where sensing sites themselves bear uncertainties. Also in time-critical applications, we have to balance modeling accuracy against sensing time, which introduces noisy samples with only limited replications at each site.
Negative Feedback Regulation of Phosphatidylinositol 3‐Kinase/Akt Pathway by Over‐Expressed Cyclooxygenase‐2 in Human Epidermal Cancer Cells

While enhanced expression of cyclooxygenase (COX)‐2 has been observed in human skin epidermal cancer, the mechanisms underlying COX‐2 expression have not been completely elucidated. Recently, a role for the phosphatidylinositol‐3 (PI3) kinase pathway in COX‐2 expression has attracted attention. We investigated COX‐2 expression, PI3 kinase activity, and the phosphorylation level of Akt, a downstream effector of PI3 kinase, in the human skin cancer cell line HSC‐5. Compared to the nontumorigenic keratinocyte HaCaT, in HSC‐5 cells, COX‐2 protein expression and PI3 kinase activity were increased. The PI3 kinase inhibitor LY294002 reduced COX‐2 expression in HSC‐5 cells and, contrary to our expectation, the phosphorylation of Akt was significantly decreased. The expression of Bcl‐2, which is regulated by Akt, was reduced, and apoptosis was induced in HSC‐5 cells compared to HaCaT cells. COX‐2 inhibitor NS398 up‐regulated Akt phosphorylation. These results imply that constitutively over‐expressed COX‐2 down‐regulates the Akt phosphorylation through a negative feedback mechanism.
Dynamic, inter-subunit interactions between the N-terminal and central mutation regions of cardiac ryanodine receptor

Naturally occurring mutations in the cardiac ryanodine receptor (RyR2) have been linked to certain types of cardiac arrhythmias and sudden death. Two mutation hotspots that lie in the N-terminal and central regions of RyR2 are predicted to interact with one another and to form an important channel regulator switch. To monitor the conformational dynamics involving these regions, we generated a fluorescence resonance energy transfer (FRET) pair. A yellow fluorescent protein (YFP) was inserted into RyR2 after residue Ser437 in the N-terminal region, and a cyan fluorescent protein (CFP) was inserted after residue Ser2367 in the central region, to form a dual YFP- and CFP-labeled RyR2 (RyR2S437-YFP/S2367-CFP). We transfected HEK293 cells with RyR2S437-YFP/S2367-CFP cDNAs, and then examined them by using confocal microscopy and by measuring the FRET signal in live cells. The FRET signals are influenced by modulators of RyR2, by domain peptides that mimic the effects of disease causing RyR2 mutations, and by various drugs. Importantly, FRET signals were also readily detected in cells co-transfected with single CFP (RyR2S437-YFP) and single YFP (RyR2S2367-CFP) labeled RyR2, indicating that the interaction between the N-terminal and central mutation regions is an inter-subunit interaction. Our studies demonstrate that FRET analyses of this CFP- and YFP-labeled RyR2 can be used not only for investigating the conformational dynamics associated with RyR2 channel gating, but potentially, also for identifying drugs that are capable of stabilizing the conformations of RyR2.
PRIME: Phase retrieval via majorization-minimization technique

This paper considers the phase retrieval problem where the measurements consist of only the magnitude of several linear measurements of the unknown. In total, four algorithms are proposed using different majorization-minimization techniques. They are preferred to existing benchmark methods since at each iteration a simple closed- form solution is computed to monotonically decrease the original objective function. Experimental results validate that our algorithms outperform existing methods in terms of mean square error and successful recovery.
A novel transmission scheme based on impulsive synchronization of two Colpitts chaotic systems

In this work, a transmission scheme based on impulsive synchronization of two chaotic Colpitts oscillators is proposed. The transmitter and the receiver are both composed of two chaotic Colpitts oscillators. The first oscillator of the transmitter is intended to be impulsively synchronized with the first oscillator of the receiver. The message to be sent is included by the inclusion method in the second Colpitts oscillator of the transmitter. The principle of the proposed method is based on the reconstitution of the message at the level of the second Colpitts oscillator that passes at first by the impulsive synchronization of the first oscillators of the transmitter and the receiver. Simulation results are presented to highlight the performances of the proposed method.
Not every friend on a social network can be trusted: Classifying imposters using decision trees

There is an alarming news recently revealed on media that 8.7 percent of users on Facebook are fake; this amounts to more than 83 million accounts worldwide. Consequently this huge number of fake users whose profiles were unverified translates to the potential dangers ranging from espionage, identity thievery, information misuse and loophole to privacy compromise to the users and their families. Nowadays with the popularity of online social networks (OSN), it is easy to footprint a potential target from the information easily trawled from the Web. Anyone can simply impose as somebody else that s/he claimed to be, without checking whether the information is genuine or not. For example it is so easy to impersonate one's identity on OSN by supplying fake photos and false names, which will go preemptively unchecked by Facebook. In this paper, a preliminary experiment of applying decision tree classification algorithms is presented, for identifying imposters from a pool of “friends” in Facebook. The classification approach is similar to that of classifying spams from legitimate emails except the attributes of a user's account is taken into consideration instead of text-mining the message contents. An accuracy of 92.1% is demonstrated to be achievable using the classification techniques.
Large abdominal mass as clinical presentation of plasmablastic lymphoma

Plasmablastic lymphoma (PBL), a very aggressive variant of diffuse large B cell lymphoma (DLBCL), has been described initially as a rapidly progressive and almost invariably fatal diffuse large-cell lymphoma with plasmablastic features. Immunohistochemical findings showed generally CD20 antigen negative and VS38c, CD138 and MUM 1 positives. This neoplasm was initially described almost exclusively involving the jaw and oral mucosa in HIV-positive patients. However, most recently, the clinical spectrum of the disease has been expanding, with a number of single case reports in HIV-negative patients and with extra-oral manifestations. Correspondence to: Marcelo Corti, Department of HIV/AIDS, Infectious Diseases, F. J. Muñiz Hospital, Puán 381 2o floor, Postal code C 1406 CQG, Buenos Aires, Argentina, Tel: +54-114-432-3762 E-mail: marcelocorti@fibertel.com. ar
Uracil‐tegafur as an adjuvant for hepatocellular carcinoma: A randomized trial

Frequent recurrence of hepatocellular carcinoma (HCC) after surgery remains a major clinical problem. This randomized controlled trial evaluated whether postoperative adjuvant therapy with oral uracil‐tegafur (UFT) prevents recurrence of HCC. A total of 160 patients who underwent curative hepatic resection for HCC were randomly assigned to receive either 300 mg/day of UFT for 1 year after surgery (n = 79, UFT group) or surgery alone (n = 80, control group). The primary endpoint was recurrence‐free survival, and the secondary endpoint was overall survival. Other study variables included liver function and type of recurrence. During a median follow‐up of 4.8 years (range: 0.5‐7.9), recurrence‐free survival curves in the groups were similar (P = .87). Overall survival was slightly but not significantly worse in the UFT group than in the control group (P = .08). The rates of recurrence‐free and overall survival at 5 years were 29% and 58%, respectively, in the UFT group, as compared with 29% and 73%, respectively, in the control group. The hazard ratio for recurrence in the UFT group, relative to the control, was 1.01 (95% confidence interval: 0.84‐1.22, P = .87). The proportion of patients with advanced recurrence (i.e., multiple, extrahepatic, or associated with vascular invasion) was significantly higher in the UFT group (74%, 43 of 58 patients with recurrence) than in the control group (53%, 30 of 57) (P = .02). In conclusion, our results offer no evidence to support potential benefits of adjuvant chemotherapy with UFT after surgery in patients with HCC and suggest that such treatment may even worsen overall survival. (HEPATOLOGY 2006;44:891–895.)
THE CONVENTIONAL RESTRICTIVE AND THE MODERN LIBERAL INTERPRETATION OF SECTION 30 OF THE EVIDENCE ACT

Section 30 of the Evidence Act allows the confession of an accused to be admitted against the co-accused. However, since it is a radical and dangerous departure from the rule that hearsay should not be admitted, the Indian and Malaysian Courts have not recognized such confession as falling within the definition of ‘evidence’. It can only be used as a last resort and hence has been strictly construed throughout. But Singaporean Courts have now given it a liberal construction and elevated it to the status of a rule of evidence. The researcher’s view is that this is dangerous and our courts should be wary of following Singaporean Courts’ judicial thinking.
Phospholipids Present in Oxidized Low-Density Lipoprotein C-Reactive Protein and Annexin A5 Bind to Distinct Sites of Negatively Charged

Objective —To investigate binding of C-reactive protein (CRP) and annexin A5, 2 proteins with high affinity for negatively charged phospholipids, to oxidized low-density lipoprotein (LDL) and the consequences of these interactions for subsequent binding of oxidized LDL to monocyte/macrophage-like U937 cells. Methods and Results —We found that CRP and annexin A5 at physiological concentrations bind Ca (cid:1)(cid:1) dependently to oxidized phosphatidylcholine present in oxidized LDL but not to native LDL. Binding of CRP to oxidized LDL did not interfere with binding of annexin A5, and vice versa. In the presence of 2 to 10 mg/L CRP, binding of 125 I-labeled oxidized LDL to undifferentiated U937 cells increased 50% to 100%. This effect was independent of the presence of complement and could be inhibited by irrelevant IgG and by antibodies to CD64 but not by annexin A5. Annexin A5 alone had no effect on binding of oxidized LDL to the cells. Conclusions —These findings suggest that: (1) CRP and annexin A5 at physiological concentrations bind to distinct sites of negatively charged phospholipids present in oxidized LDL; (2) CRP enhances binding of oxidized LDL to monocytic/macrophage-like cells via Fc (cid:1) receptors; and (3) annexin A5 does not antagonize the CRP-induced enhanced binding of oxidized LDL to U937 cells. ( Arterioscler Thromb Vasc Biol . 2005;25:717-722.)
Hydrostatic pressure rescues native protein from aggregates.

Misfolding and misassembly of proteins are major problems in the biotechnology industry, in biochemical research, and in human disease. Here we describe a novel approach for reversing aggregation and increasing refolding by application of hydrostatic pressure. Using P22 tailspike protein as a model system, intermediates along the aggregation pathway were identified and quantitated by size-exclusion high-performance liquid chromatography (HPLC). Tailspike aggregates were subjected to hydrostatic pressures of 2.4 kbar (35,000 psi). This treatment dissociated the tailspike aggregates and resulted in increased formation of native trimers once pressure was released. Tailspike trimers refolded at these pressures were fully active for formation of infectious viral particles. This technique can facilitate conversion of aggregates to native proteins without addition of chaotropic agents, changes in buffer, or large-scale dilution of reagents required for traditional refolding methods. Our results also indicate that one or more intermediates at the junction between the folding and aggregation pathways is pressure sensitive. This finding supports the hypothesis that specific determinants of recognition exist for protein aggregation, and that these determinants are similar to those involved in folding to the native state. An increased understanding of this specificity should lead to improved refolding methods.
A Robust Electronic Voting Scheme Against Side Channel Attack

YI-NING LIU, WEI GUO, CHI CHENG, CHINGFANG HSU, JUN-YAN QIAN AND CHANG-LU LIN Guangxi Key Lab of Trusted Software Guilin University of Electronic Technology Guilin, 541004 P.R. China School of Computer Science China University of Geosciences Wuhan, 430074 P.R. China Computer School Central China Normal University Wuhan, 430079 P.R. China College of Mathematics and Computer Science Fujian Normal University Fuzhou, 350117 P.R. China E-mail: ynliu@guet.edu. cn
Speculative bubbles and the real estate market application of the sequential ADF test

The aim of this paper is to detect the presence of a real estate bubble in the US home market. Inability of classic methods such as stationary tests and co-integration methods to determine explosive behaviour in financial markets was our motivation to use a recent econometric technique developed by Phillips, Shi and Yu. This method is perfectly efficient and is considered as a bubble-detecting algorithm. Our empirical results point to the presence of an explosive behaviour in the data. Therefore, we concluded that the US home market was shaken by several bubbles before the sub-prime crisis.
Personality Inferences Drawn about Abusive Mothers

This study investigated the personality inferences people draw about abusive mothers by having 287 subjects view videotapes of four female targets engaged in social discourse with other adults. Some subjects were primed beforehand to believe that the female targets had physically abused or neglected their child and other subjects viewed the tapes without being primed. Afterward, all subjects rated the targets' personalities using 17 bipolar trait scales and estimating the likelihood of six social behaviors. Analyses compared the ratings of the two types of abuse groups (physical abuse and neglect) with each other and with the unprimed control group. Analysis showed that ratings of one or both of the abuse groups differed from those of the control group on 10 of the 17 trait dimensions and four of six social behaviors. Implications are drawn about the social forces experienced by abusive mothers and the possible role of such forces in therapeutic change.
Macroeconomic Effects of Factor Taxation with Endogenous Human Capital Evolution: Theory and Evidence

The distortionary effect of factor income taxation has been one of the central issues in public finance theory (for example, see Feldstein [4], Boadway [3], Homma [6], Summers [14] and Judd [8]). A tax on capital income, in contrast to a tax on labor income, has been claimed to create an intertemporal distortion that affects the future paths of macro aggregates adversely through the decumulation of physical capital. Hence, it is generally concluded in the aforementioned literature that capital taxation is more distortionary in the long run than labor taxation. ' In this paper, we revisit this issue by constructing a dynamic general equilibrium model with infinitely lived, perfectly foresighted agents. Unlike most of the existing literature, we develop a growth model in which both physical and human capital are endogenously accumulated.2 Within this framework, a tax on labor generates a distortionary effect on both human capital evolution and future dynamic paths of output and consumption, analogous to the case of capital taxation. In contrast to results in previous work, labor income taxation in our economy can be more distortionary than capital income taxation, even in the long run. Many studies, for years, have focused on welfare comparison of factor taxes. In most cases, calibration or simulation exercises are performed and there has been no empirical research to con-