Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterization of Fluorescent Eye Markers for Mammalian Transgenic Studies

Genotyping mice by DNA based methods is both laborious and costly. As an alternative, we systematically examined fluorescent proteins expressed in the lens as transgenic markers for mice. A set of eye markers has been selected such that double and triple transgenic animals can be visually identified and that fluorescence intensity in the eyes can be used to distinguish heterozygous from homozygous mice. Taken together, these eye markers dramatically reduce the time and cost of genotyping transgenics and empower analysis of genetic interaction.
Through the Looking Glass: The Role of Ethnicity and Affiliation in Responses to Terrorism in the Media

This study examined whether attitudinal and emotional responses to broadcasts of images of terrorist events differ according to ethnic group (Jewish and Arab Israelis) and outgroup affiliation during an intense wave of terrorism that occurred in Israel during 2015. Participants were 118 Jewish and 110 Arab-Israelis adults randomly allocated to a terrorism or criminal violence television broadcast. State anxiety, state anger, stereotypes, and negative attitudes toward an adversary were examined prior and subsequent to the media exposure. Findings showed significant increases in anxiety, anger, stereotypes, and negative adversary perceptions in the terrorism exposure group compared to only anxiety increases in the criminal violence exposure. In the terrorism exposure group, Jewish participants showed greater increases in negative adversary perceptions of the Palestinians than Arab Israeli participants, but both groups showed similar significant increases in levels of anxiety and anger. Exposure to broadcasts of terrorism increased willingness to negotiate with the adversary among the Arab participants, but not among the Jewish participants. In the terrorism exposure group, both Jewish and Arab Israelis with high affiliation with the Palestinian cause showed less increases in stereotypes than those with low affiliation. Findings emphasize the role of ethnicity and outgroup affiliation in responses to media exposure to terrorism images.
Violent Theatricality: Displayed Enactments of Aggression and Pain

A naked woman is tied to a cross and drenched in the blood of a sacrificial goat. A man crawls on his stomach through broken glass. A woman climbs a ladder with razor-sharp rungs. A man hangs from hooks driven through his pectoral muscles. A crowd dodges flames and flying glass and endures ear-splitting explosions to watch robotic machines destroy one another. Such activities create an immediate atmosphere of crisis both in those undergoing the aggression or pain and in those witnessing it, but what ultimately becomes of this crisis? Does it completely destroy the protocols of spectator and performer around which theatre turns? Does it degenerate into a voyeuristic thrill akin to the Roman coliseum? Or are more complex relations negotiated between the immediate stress on human flesh and the ontological formalities of art, theatre, and performance? To what extent can theatricality embody aggression and pain without becoming something else or without the aggression and pain becoming (uneasily) their own simulacra?
Role of Galectins in Multiple Myeloma

Galectins are a family of lectins that bind β-galactose-containing glycoconjugates and are characterized by carbohydrate-recognition domains (CRDs). Galectins exploit several biological functions, including angiogenesis, regulation of immune cell activities and cell adhesion, in both physiological and pathological processes, as tumor progression. Multiple myeloma (MM) is a plasma cell (PC) malignancy characterized by the tight adhesion between tumoral PCs and bone marrow (BM) microenvironment, leading to the increase of PC survival and drug resistance, MM-induced neo-angiogenesis, immunosuppression and osteolytic bone lesions. In this review, we explore the expression profiles and the roles of galectin-1, galectin-3, galectin-8 and galectin-9 in the pathophysiology of MM. We focus on the role of these lectins in the interplay between MM and BM microenvironment cells showing their involvement in MM progression mainly through the regulation of PC survival and MM-induced angiogenesis and osteoclastogenesis. The translational impact of these pre-clinical pieces of evidence is supported by recent data that indicate galectins could be new attractive targets to block MM cell growth in vivo and by the evidence that the expression levels of LGALS1 and LGALS8, genes encoding for galectin-1 and galectin-8 respectively, correlate to MM patients’ survival.
Deficit in Executive Functioning in Patients With Schizo-Obsessive Disorder

فده : ديدج يشهوژپ تايبدا رد ، للاتخا ود راظتنا زا رتلااب يدوبمه نازيم نييبت رد يساوسو و اينرفوزيكسا – حلاطصا يرابجا » وزيكسا – يساوسو « هك تسا هديدرگ داهنشيپ فيصوت تسا ييازجم يصيخشت هقبط هدننك . وحم زا يكي ،هنيمز نيا رد يشهوژپ ياهر بصع صياقن خرمين اي وگلا يياسانش – يم هورگ ريز نيا رد صاخ يتخانشناور ب دشا . نيا ناراميب رد يتوافتم ييارجا يراكژك يوگلا ايآ هك هدوب شسرپ نيا هب خساپ يپ رد هعلاطم وزيكسا – اميب نيا رد للاتخا ود هب طوبرم يتخانش تلااكشا اي دراد دوجو يساوسو نار هب يم هدوزفا رگيدكي ؟دنوش شور : ،يعطقم شهوژپ حرط كي بلاق رد ،روظنم نيا هب 20 راميب وزيكسا – يساوسو ، 20 و اينرفوزيكسا هب لاتبم راميب 20 يساوسو راميب – هدرسفاريغ يرابجا اب 20 نومزآ رد دركلمع ظاحل زا ملاس راجنهب درف رارق هسياقم دروم ييارجا ياهدركراك ياه تفرگ دن . هتفاي اه : وزيكسا هورگ ود – راچد ييارجا ياهدركراكرد كينرفوزيكسا و يساوسو يساوسو ناراميب يلو دنتسه لاكشا – ا راجنهب هورگ اب يرادانعم توافت هدرسفا ريغ يرابج دنرادن . هب وزيكسا هورگ هولاع – تلااكشا ياراد كينرفوزيكسا هورگ اب هسياقم رد يساوسو شيب ييارجا ياهدركراك دنتسه يرت . هجيتن يريگ : هب يم رظن هب طوبرم توافت نيا دسر » بيسآ هدوزفا يسانش « بصع صياقن توافتم يوگلا هب طوبرم ًلاامتحا هكلب هدوبن – تسا ناراميب نيا يتخانشناور .
Animal cognition and human personality

Reinforcement Sensitivity Theory (RST) is based, both in terms of data and concepts, on the experimental analysis of (non-human) animal behaviour. Some workers in emotion and human personality research question its validity on this count alone. But, since Galileo and Copernicus, our world has clearly not been the centre of the wider universe. Likewise, since Darwin, biology has accepted the essential continuity between our own and other species (with chimpanzees, genetically speaking, being 98 per cent human), where the human form and characters have not been the goal of evolution. In this chapter we evaluate the claim that emotion and personality, nonetheless, remain distinct from the rest of biology; that with them it is still the case that ‘the only proper study of mankind is man’. This will clarify the foundations on which RST rests. Emotion and personality can be approached from more ‘cognitive’ (e.g., Matthews, chapter 17) or ‘biological’ (McNaughton and Corr, chapter 2) perspectives. But these are really different sides of the same coin. There are cases where cognitive or biological factors may seem relatively more important. But both kinds of case exist. This requires a true theoretical and empirical integration to take a combined ‘biocognitive’ perspective. Each approach fills the gaps left by the other. Their combination leads to a richer picture and a deeper understanding. To many this is so obvious that to argue is to attack a straw man. But resistance to the idea of non-human cognition, or that human emotion and personality are just like other animals, while tacit is widespread. It is fuelled by a range of anthropocentric fallacies that die hard. But neural and behavioural homologies across species have illuminated much of human cognition, emotion and personality – perhaps nowhere more so than with RST. A focus on language or surface aspects of cognition can blind us to this fact. But, after many years in the scientific wilderness, emotion (which in terms of everyday application is the most important aspect of
Dissipative dynamics of quantum and classical correlations for two-qubit under two-side and one-side decoherence

The dissipative dynamics of classical correlation(CC), quantum discord(QD) and entanglement (QE) of two qubits in two-side and one-side decoherence models are inves- tigated under Markovian environments. We find the sudden change QD as well as CC and sudden death of entanglement (ESD). The results show that QD and QE decay faster with the increasing of squeezing parameter r; the dipole-dipole interaction W under two-side decoherence leads to the oscillation of quantum discord and concurrence for initial non- eigenstates; while in all cases when entanglement suddenly disappears, quantum discord keeps nonzero under same conditions.
Adaptive synergies: An approach to the design of under-actuated robotic hands

To match the richness and complexity of the sensory and motor functionalities of a human hand with a robust and economically reasonable robotic device remains one of the hardest challenges in the field. Previous work has explored the possibility to exploit insight from neuroscientific results on postural correlation patterns (synergies) taming the sensorimotor complexity of hands. The postural synergy model has been recently extended to account for grasp force control through a model of “soft synergies” which incorporate hand compliance. In this paper we propose a first translation of such principles in the design of a robot hand. It so turns out that the implementation of the soft synergy model in an effective design is not obvious. The solution proposed in this paper rests on ideas coming from under-actuated hand design. We give a synthesis method to realize a desired set of soft synergies through the principled design of adaptive under-actuated mechanisms, which we call the method of adaptive synergies. This approach leads to the design and implementation of a prototype modular hand capable of accommodating an arbitrary number of synergies. The effectiveness of the design is shown in grasping simulations and experiments.
D-dimer can predict survival in patients with chronic atrial fibrillation

High mean levels of D-dimers (DD), markers of fibrin product and degradation, have been reported in patients with atrial fibrillation. In order to determine the predictive value of DD, 125 consecutive patients (mean age, 78 years) with chronic atrial fibrillation without acute disease were prospectively included. DD were quantified by Liatest at inclusion. Patients were followed for a mean duration of 2 years. DD and age at inclusion were significantly higher in patients who would die (n = 54) than in those who would not (n = 65). After multiple analysis of variance, age was not significantly related to prognosis (P = 0.36); low DD (P = 0.03) and oral anticoagulant therapy (P = 0.0192) were independently related to survival. In conclusion, a single determination of DD can strongly predict survival over the following 2 years. It may contribute to the risk stratification and perhaps to the choice of the antithrombotic therapy in high-risk patients with elevated DD.
Efficient Human Body Configuration using MCMC

Body configuration based on the Silhouette. We propose an effective Model based MCMC (Markov Chain Monte Carlo) method under bayesian framework to solve the configuration problem, in which the best configuration could be defined as MAP (maximize a posteriori probability). This model based MCMC utilizes the human body model to drive the MCMC sampling from the solution space. It converses the original high dimension space into a restricted sub-space constructed by the human model and uses a hybrid sampling algorithm. We choose an explicit human model and carefully select the likelihood functions to represent the best configuration solution. The experiments show that this method could get an accurate configuration and timesaving for different human from multi-views.
A multi-sources data assimilation system for catchment scale research

A multi-sources data assimilation system has been developed for the catchment scale land water and energy cycle researches. The land surface model, microwave radiative transfer model and ensemble Kalman filter have been coupled in this system, the high performance computing was also considered. This system is being used in the data assimilation of soil moisture, soil temperature, microwave brightness temperature and snow water equivalent at catchment scale.
Governing the Commons: The Evolution of Institutions for Governing the Commons: The Evolution of Institutions for Collective Action Collective Action

In 1985, the National Academy of Sciences sponsored a conference in Annapolis, Maryland, to discuss common property resource management. This conference was a watershed in the development of the theoretical underpinning of institutional design for successful common pool resource (CPR) management. Since then, an international network of over 2,000 researchers has developed, and the International Association for the Study of Common Property (IASCP), formed in 1989, has held two successful international conferences. Dominating the intellectual evolution of the field has been the work of Elinor Ostrom, co-director of the Workshop in Political Theory and Policy Analysis at Indiana University. Her book, Governing the Commons, presents a lucid exposition of the current state of institutional analysis of common property problems. Part of the Cam-bridge series on Political Economy of Institutions and Decisions, the book addresses how common pool resources may be managed successfully without falling prey to the "tragedy of the commons. " Common pool resources are characterized by subtractability (i.e., withdrawal by one user reduces the amount of the resource left for other users) and joint use by a group of appropriators. Thus, a common village grazing field has forage for a limited number of beasts, and all the villagers are entitled to pasture their animals on the field. Community rules of access and management are required to sustain the field from season to season. Problems in managing CPRs arise when the rational individual determines that he will still have access to the resource even if he does not fully contribute to its maintenance (the "free rider" problem). An extensive literature discusses the effect of free riders, concluding that common pool resources will inevitably fall into ruin. One of two solutions is usually offered to avoid this problem: centralized governmental regulation or privatization. Noting the numerous occasions in which common pool resources are managed successfully with neither centralized governmental control nor privatization, Ostrom argues for a third approach to resolving the problem of the commons: the design of durable cooperative institutions that are organized and governed by the resource users. In Governing the Commons she examines small-scale common-pool resources. Resource user groups examined range in size from 50-15,000 people who rely substantially on the common pool resource for their economic well-being. She has further
Plasmin Produces an E-Cadherin Fragment That Stimulates Cancer Cell Invasion

Abstract Matrix metalloproteases from the cell surface cleave an 80 kDa Ecadherin fragment (sECAD) that induces invasion of cancer cells into collagen type I and inhibits cellular aggregation. Conditioned media from MDCKts.srcCl2 cells at 40 C and 35 C, PCm.src5 and COLO-16 cells at 37 C contained spontaneously released sECAD; these 48 h old conditioned media were capable of inhibiting Ecadherin functions in a paracrine way. Here we show direct cleavage of the extracellular domain of Ecadherin by the serine protease plasmin. sECAD released by plasmin inhibits Ecadherin functions as evidenced by induction of invasion into collagen type I and inhibition of cellular aggregation. This functional inhibition by sECAD was reversed by aprotinin or by immunoadsorption on protein Sepharose 4 fast flow beads with antibodies against the extracellular part of Ecadherin. Our results demonstrate that plasmin produces extracellular Ecadherin fragments which regulate Ecadherin function in cells containing an intact Ecadherin/ catenin complex.
Who Stays, Who Goes: A 12-Month Follow-Up Study of New Members of Consumer Run Organizations

Consumer run-organizations (CROs) are participant-driven mutual aid/ self-help settings that have acquired a non-profit status and relay on external grant support. CROs have their roots in self-help groups but besides hosting group meetings they also provide their participants with educational and leadership opportunities typically found in other small non-profit organizations. Active participation in CROs has been shown to have a positive impact on recovery from mental illness, yet we know little about the characteristics of people who are most likely to become long-time active CRO members. All new members (n = 172) of 10 CROs were interviewed at baseline and followed up at 12 months to see if they were still CRO members. Results of discriminant analysis indicated that individuals who were older, had larger social networks, lived longer in their communities, spent more time home alone, and scored lower on control in daily life were more likely to still be members of their respective CROs 12 months after their baseline *Research supported through a jointly funded grant from the National Institute of Mental Health (NIMH) and Substance Abuse & Mental Health Services Administration (SAMHSA) – R34 HCP0607
Guanine nucleotide binding proteins may modulate gating of calcium channels in vascular smooth muscle. I. Studies with fluoride.

Fluoride (F-), a known stimulator of G-proteins, was used to examine the relationship between G-proteins and calcium channels (CaC) in rat vascular smooth muscle (VSM). Treatment of isolated rat tail artery helical strips with F- (2.5-20 microM) produced a Ca++-dependent contraction. In the absence of added AlCl3, subthreshold NaF shifted the KCl, as well as the arginine vasopressin and norepinephrine concentration-related tension curves to the left. Nifedipine and verapamil, known CaC blockers, inhibited the NaF-related contraction. AlCl3 (20 microM), which is required for G-protein stimulation by F-, strikingly potentiated the contractile response to F-. The NaF-induced contraction was relaxed by 3-isobutyl-1-methylxanthine as well as by forskolin and by dibutyryladenosine-cyclic AMP, and the effect therefore may be independent of cAMP. 45Ca-uptake was elevated by NaF, and partially blocked by nifedipine and verapamil. NaF also inhibited the basal and forskolin-stimulated cAMP production, suggesting that F- stimulated the putative Gi in the intact VSM cells. NaF stimulated accumulation of IP in a concentration-dependent manner, indicating that F- stimulated the putative G-protein Gp which couples various receptors to hydrolysis of phosphoinositides and mobilization of Ca++. These results indicate that NaF-induced vasoconstriction is related to the opening of the CaC in the plasma membrane and perhaps a subsequent entry of the extracellular Ca++ into the cell. (ABSTRACT TRUNCATED AT 250 WORDS)
Is what you measure what you expect? Factors affecting smartphone-based mobile network measurement

Many apps have been developed to measure the performance of mobile networks. Unfortunately, their measurement results may not be what users expect, because the results could be biased by various factors and the apps' descriptions may confuse users. Although a few recent studies pointed out several factors, they missed other important factors and lacked of finegrained analysis on the factors and measurement apps. Moreover, none has studied whether or not the descriptions of such apps will mislead users. In this paper, we conduct the first systematic study of the factors that could bias the result from measurement apps and their descriptions. We identify new factors, revisit known factors, and propose a novel approach with new tools to discover these factors in proprietary apps. We also develop a new measurement app named MobiScope for demonstrating how to mitigate the negative effects of these factors. Furthermore, we construct enhanced descriptions for measurement apps to provide users more information about what is measured. The extensive experimental results illustrate the negative effects of various factors, the improvement in performance measurement brought by MobiScope, and the clarity of the enhanced descriptions.
Jogging over a distance: the influence of design in parallel exertion games

"Exertion games" are gaming interactions with technology in which users invest significant physical effort. They form part of an emerging phenomenon with many physical and social health benefits, and we believe that the social and exertion interactions are intertwined. Recent technological developments, particularly in the sports and game domain, have been proposed to augment these exertion activities. However, we only have a limited understanding of how this relationship between social and exertion aspects can be successfully facilitated by the design, especially in mediated environments. In this paper, we present initial findings of a qualitative study of "Jogging over a Distance" that illustrate how technology design can facilitate a social game experience despite participants running in opposite sides of the world. From this study, we derived conceptual themes that offer an analytical and descriptive account of the influence of design on the relationship between exertion and social aspects. Our work aims to support the analysis of existing, and provide guidance for, the design of future games that aim to utilize the many benefits of social exertion.
Ätiologie und Therapie der Alpträume

: Theories and evidence on the aetiology of the 3 distinct forms of nightmares (REM nightmares, NREM night terrors, posttraumatic nightmares) are exposed. Depth psychological theories try an aetiological integration of the nightmare into their respective theories of dream formation, whereas empirical work stresses the personality-typical traits of nightmare sufferers. Clinical casework reports relate anxiety dreams to existing psychological and somatic pathology. Posttraumatic nightmares are repetitive mental reactions to heavy traumatic or life-threatening events. Nightmare therapy, insofar as it has become an independent variety of psychological intervention, uses drug medication, which is able to suppress the symptom of the sufferer when on the drug, whereas behavioural and insight treatment not only eliminate the dreams, but can have an enduring healing effect.
Local-to-Global Consistency Implies Tractability of Abduction

Abduction is a form of nonmonotonic reasoning that looks for an explanation, built from a given set of hypotheses, for an observed manifestation according to some knowledge base. Following the concept behind the Schaefer's parametrization CSP(Gamma) of the Constraint Satisfaction Problem (CSP), we study here the complexity of the abduction problem Abduction(Gamma, Hyp, M) parametrized by certain (omega-categorical) infinite relational structures Gamma, Hyp, and M from which a knowledge base, hypotheses and a manifestation are built, respectively. We say that Gamma has local-to-global consistency if there is k such that establishing strong k-consistency on an instance of CSP(Gamma) yields a globally consistent (whose every solution may be obtained straightforwardly from partial solutions) set of constraints. In this case CSP(Gamma) is solvable in polynomial time. Our main contribution is an algorithm that under some natural conditions decides Abduction(Gamma, Hyp, M) in P when Gamma has local-to-global consistency. As we show in the number of examples, our approach offers an opportunity to consider abduction in the context of spatial and temporal reasoning (qualitative calculi such as Allen's interval algebra or RCC-5) and that our procedure solves some related abduction problems in polynomial time.