Miracle-dz/UniFAR-FTUs huggingface dataset:
Increased maternal cortisol in late-gestation ewes decreases fetal cardiac expression of 11beta-HSD2 mRNA and the ratio of AT1 to AT2 receptor mRNA.

Moderately elevated maternal cortisol levels late in gestation cause enlargement of the fetal sheep heart. We have used quantitative real-time PCR to examine expression of candidate genes in fetal hearts from mothers in whom cortisol levels were increased (by infusion of 1 mg cortisol.kg(-1). day(-1)) or decreased (by adrenalectomy and replacement to 0.5 mg cortisol.kg(-1). day(-1)) from 115 to 130 days gestation. Control ewes were not treated with steroid. Expression of mineralocorticoid receptor (MR), glucocorticoid receptor (GR), 11beta-hydroxysteroid dehydrogenases 1 and 2 (11beta-HSD1 and -2), IGF I and II, IGF receptors 1 and 2 (IGF-1R and IGF-2R), endothelial nitric oxide synthase, VEGF, myotrophin, angiotensinogen, the angiotensin receptors 1 and 2 (AT1R and AT2R), and the angiotensin converting enzymes 1 and 2 were measured. MR mRNA abundance in fetal hearts was found to be similar to that in adult kidney and hippocampus. Although there were no significant changes in most genes, 11beta-HSD2 and IGF-1R expression were significantly decreased in the high cortisol group and 11beta-HSD2 expression negatively correlated to left ventricular wall thickness. There was also a significant change in the ratio of AT receptor expression, with increased AT2R and decreased AT1R in the high cortisol group. MR, GR, and 11beta-HSD1 immunoreactivity was found in cardiomyocytes and cardiac blood vessels in 126-128 day fetal sheep; in contrast 11beta-HSD2 staining was predominantly in blood vessels. These results indicate that cortisol could indeed act in the fetal heart to induce enlargement and suggest that the renin-angiotensin system may play a role.
RELEASE‐MODULATING ACETYLCHOLINE RECEPTORS ON CHOLINERGIC NEURONES OF THE GUINEA‐PIG ILEUM

1 Twitch responses of the guinea‐pig ileum to electrical transmural stimulation (0.2 Hz) were smaller after a dose of acetylcholine (ACh) than before it. The magnitude of the post‐ACh inhibition of twitch was dose‐dependent. 2 The post‐ACh inhibition of twitch could not be explained in terms of post‐junctional desensitization and was not modified by guanethidine, thymoxamine, propranolol or naloxone. Inhibition of twitch also followed high frequency stimulation (10 Hz) but this inhibition, unlike that following ACh, was partially antagonized by naloxone. 3 Hexamethonium (C6) in concentrations known to block contractions to nicotine, potentiated the post‐ACh inhibition of twitch and modified the pattern of recovery. An initial rapid phase followed by a slower phase was converted by C6 to an initial slow phase followed by a more rapid rate of recovery. 4 The C6‐sensitive (nicotinic) component of twitch recovery after ACh was also dose‐dependent and contributed greatly to the rapid recovery during the first minute after ACh washout, whereas during the same period the C6‐resistant inhibition remained relatively constant; thereafter both components declined. The C6‐resistant inhibition was considered to be due to the activation of prejunctional muscarinic receptors. 5 5‐Hydroxytryptamine (5‐HT) and nicotine also caused inhibition of twitch but the pattern of response differed from those due to ACh, the maximum inhibition usually being produced 1 min after recommencing stimulation. High doses of 5‐HT produced inhibitory responses similar to those following ACh, whereas nicotine produced a characteristic triphasic pattern of response. 6 It is concluded that ACh acts on at least two prejunctional receptors subserving a modulatory role on transmitter release, a nicotinic receptor whose activation enhances ACh output and a muscarinic receptor whose activation leads to an inhibition of transmitter secretion.
Arbitrary function approximation in HDLs with application to the N-body problem

A module generator is described that allows for the generation of synthesizable VHDL modules which implement arbitrary functions in fixed point precision using the Symmetric Table Addition Method (STAM). This module generator was interfaced to a high level synthesis tool "fly" which automatically generates fully-pipelined circuits from a Perl-like language. The resulting system was applied to the N-body problem and results are presented. It was found that a function generator module is a very useful addition to a hardware description language.
Potential and Limits of Using Post-edits as Reference Translations for MT Evaluation

This publication has emanated from research supported by the TRAMOOC project (Translation for Massive Open Online Courses), partially funded by the European Commission under H2020-ICT-2014/H2020-ICT-2014-1 under Grant Agreement Number 644333, and by a research grant from Science Foundation Ireland (SFI) under Grant Number SFI/12/RC/2289 (Insight)
Study on the Mechanism of Oxidative Damage and Genotoxicity induced by BBP in Hepatic cells of Mice

To illustrate the possible function of genotoxicity of BBP on DNA, this study took mice livers as experimental materials to detect the levels of DNA-protein crosslinks (DPC), the activity of surperoxide dismutase (SOD), and the contents of malondialdehyde (MDA) with intraperitioneal injection of different doses of BBP for two consecutive 14 days. DPC levels in hepatic cells showed a dose-dependent enhancement after administration of BBP. Significant DPC was observed in the 500 and 1000 mg/(kgldrd) (P<0.01) groups, compared to the control group. A decrease in the activities of SOD, companied by a increase in the MDA contens, was observed. Significant changes of SOD activity could be observed in 250, 500 and 1000 mg/(kgldrd) (P<0.01) groups. When the exposure doses were 250, 500 and 1000 mg/(kgldrd), there were dramatic changes in the levels of MDA (P<0.01). To conclusion, high levels BBP induced significant oxidative damage, then caused damage to DNA.
Training potential program implementers of the Project P.A.T.H.S. (Secondary 1 Program) in Hong Kong

To strengthen the implementation quality of the Tier 1 Program (Secondary 1 Level) of the Project P.A. T.H. S. in Hong Kong, a 20-hour training program is provided to the potential program implementers before program implementation. A total of 49 workshops were conducted with 2,359 teachers, social workers and allied professionals participating in the program. This paper describes the objectives, development and implementation of the Secondary One Training Program delivered in the first cycle of the P.A. T.H. S. Project. Conceptual and practical issues underlying the training program as well as the implications for future training programs are also discussed.
4.8 A 0.44e−rms read-noise 32fps 0.5Mpixel high-sensitivity RG-less-pixel CMOS image sensor using bootstrapping reset

In the past several years, CMOS image sensors (CISs) with sub-single-electron noise level, particularly, deep sub-electron read noise (less than 0.5e-rms), have been reported. Such an ultra-low noise level is realized with a reduced floating diffusion (FD) node capacitance for attaining the high pixel conversion gain (CG) [1,2], and a high-gain readout circuitry with noise-reduction capabilities [3,4]. Recently, a reset-gate-less (RGL) CMOS image sensor has been reported [5]. It shows an excellent read noise performance using an optimized pixel structure for high CG and high-gain column ADC with multiple sampling. In this technique, however, a very high pulsed voltage of approximately 25V for the FD reset is essential to cause a punch-through effect. It is not suitable for image sensors with high pixel resolution and high-speed signal readout.
Efficient routing in large sensor grids supporting mobile drains

Different applications for Wireless Sensor Networks (WSN), such as intruder detection and pursuit scenarios, require the support for mobility. In this paper we propose the novel Mobile-drain Routing for Large Grids (MRLG) algorithm, which is intended to support drain mobility in WSNs in an efficient manner. MRLG allows reducing the routing load by relying on local route recovery processes, which provides significant efficiency in scenarios with a large number of sensors. Preliminary experimental results show that, when compared to typical proactive routing strategies based on drain announcements, the MRLG algorithm allows to significantly boost performance in terms of packet delivery ratio, end-toend delay, and routing overhead.
Impact of pharmacy automation on patient waiting time: an application of computer simulation.

INTRODUCTION This paper aims to illustrate the use of computer simulation in evaluating the impact of a prototype automated dispensing system on waiting time in an outpatient pharmacy and its potential as a routine tool in pharmacy management. MATERIALS AND METHODS A discrete event simulation model was developed to investigate the impact of a prototype automated dispensing system on operational efficiency and service standards in an outpatient pharmacy. RESULTS The simulation results suggest that automating the prescription-filing function using a prototype that picks and packs at 20 seconds per item will not assist the pharmacy in achieving the waiting time target of 30 minutes for all patients. Regardless of the state of automation, to meet the waiting time target, 2 additional pharmacists are needed to overcome the process bottleneck at the point of medication dispense. However, if the automated dispensing is the preferred option, the speed of the system needs to be twice as fast as the current configuration to facilitate the reduction of the 95th percentile patient waiting time to below 30 minutes. The faster processing speed will concomitantly allow the pharmacy to reduce the number of pharmacy technicians from 11 to 8. CONCLUSION Simulation was found to be a useful and low cost method that allows an otherwise expensive and resource intensive evaluation of new work processes and technology to be completed within a short time.
Compassion in Jewish, Christian and Secular Nursing. A Systematic Comparison of a Key Concept of Nursing

The major thesis of this research is that the biblical topos of the Compassionate God was the original model of compassionate nursing and that this topos represents the core of the ethics of compassion and of caring in nursing today. The analysis of the literary sources of the first four centuries CE supports this assumption for the eastern Mediterranean area, i.e. the birthplace of Jewish and Christian nursing (see first part of this article). Works of love and compassion on behalf of the suffering and the sick were one of their main features, and distinguished them from the polytheistic Greek and Roman culture. In the course of this period “the Church” and “the Synagogue” became the controlling institutions of nursing. They contributed to their consolidation. This is not the case for modern and post-modern nursing. Since the Enlightenment these are no longer determined by religious institutions. Secular societal movements and the rising of the medical
A multiplierless parallel HEVC quantization hardware for real-time UHD 8K video coding

One step required several times for current video encoders is the residual coding loop, composed of the direct transformation, direct quantization, inverse quantization, and inverse transformation. These operations demand high throughput and low latency since their outputs must be processed by other steps of the coder. This paper proposes a high-throughput parallel and multiplierless hardware architecture for the HEVC direct quantization targeting real-time processing of Ultra-High Definition 8K videos. The proposed architecture support frequency dependent quantization steps. The binary multiplications were replaced by multiple constant multiplications in order to improve the throughput and to reduce the area and power dissipation. The developed design is able to process 32 samples in parallel, which represents one line of the biggest HEVC transform block. The ASIC synthesis results, obtained with Nangate 45nm standard cells library, show that the proposed architecture is able to quantize about 8 billion coefficients per second, when running at 186.6 MHz, with a gate count of 168,330. This throughput is enough to process UHD 8K videos at 120 fps.
Dialogue on Point and Level System: Reply to Tompkins-Rosenblatt and VanderVen

ABSTRACT Mr. Tompkins-Rosenblatt's (TR) and Dr. VanderVen's (VV) article: “Perspective on Point and Level System in Residential Care: A Responsive Dialogue,” in Residential Treatment for Children and Youth (2005, 22 [3], 1–18), which consisted of an exchange of letters, is a critique of my article: “The Application of a Reinforcement/Level System in the Residential Treatment of Adolescents. ” (2003, 21 [1], 17–32). Included in their diatribe are exaggerations and the taking of my ideas out-of-context, thereby distorting the debate. Their argument that all reinforcement and level systems are destructive to any young person-in-care is problematic, because they do not provide empirical evidence, nor offer a meta-analysis of the literature, to support their assertion. This paper addresses their position and counters their assertions.
Approximate nearest neighbor (ANN) search in high dimensions

x 17.1 ANN on the Hypercube 17.1. 1 Hypercube and Hamming distance Definition 17.1. 1 The set of points H d = 0, 1 d is the d-dimensional hypercube. A point p = (p 1 ,. . , p d) ∈ H d can be interpreted, naturally, as a binary string p 1 p 2. p d. The Hamming distance d H (p, q) between p, q ∈ H d , is the number of coordinates where p and q disagree. It is easy to verify that the Hamming distance comply with the triangle inequality, and is thus a metric. As we saw in previously, all we need to solve (1 + ε)-ANN efficiently, is to efficiently solve the approximate near neighbor problem. Namely, given a set P of n points in H d , a radius r > 0 and parameter ε > 0, we want to decide for a query point q whether d H Definition 17.1. 2 For a set P of points, a data-structure D = D D ≈NearNbr (P, r, (1 + ε)r) solves the approximate near neighbor problem, if given a query point q, the data-structure works as follows. Given such a data-structure one can construct a data-structure that answers approximate nearest neighbor query using O log (log d)/ε queries using an approximate near-neighbor data-structure. Indeed, the desired distance d H (q, P) is an integer number in the range 0, 1,. , d. We can build a D D ≈NearNbr data-structure for distances (1+ε)
Body size and pubertal development explain ethnic differences in structural geometry at the femur in Asian , Hispanic , and white early adolescent girls living in the U .

a Dept. of Anthropology, University of Nebraska, Lincoln, NE, USA b Dept. of Nutrition Science, Purdue University, West Lafayette, IN, USA c Dept. of Statistics, Purdue University, West Lafayette, IN, USA d Department of Human Nutrition, Food and Animal Sciences, University of Hawaii-Manoa, HI, USA e USDA, ARS, Western Human Nutrition Research Center Davis, CA, USA f University of Arizona, Tucson, AZ, USA g Ohio State University, Columbus, OH, USA h Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA
Neue Entwicklungen in der Behandlung der Migräne

Zusammenfassung Die Substanzklasse der Triptane ist bei fehlenden Neuentwicklungen nicht erweitert worden. Es liegen jedoch neue Applikationsformen vor. In Deutschland ist ein nadelfreier Injektor zur subkutanen Sumatriptanapplikation zugelassen. In den Vereinigten Staaten befindet sich eine transdermale Applikationsform des Sumatriptans mittels Pflaster in dem Zulassungsverfahren. Erprobt werden fixe Kombinationen eines Triptans mit einem nicht steroidalen Antiphlogistikum in einer Tablette, insbesondere zur Reduktion der Wahrscheinlichkeit eines Migräne-Wiederkehrkopfschmerzes, z. B. Rizatriptan mit Paracetamol oder Koffein. Als Mischpräparat ist Sumatriptan mit Naproxen in den USA zugelassen. Als Substanzen ohne direkte vasokonstriktorische Nebenwirkung werden in klinischen Studien Serotonin-5-HT-1F-Rezeptoragonisten und Calcitonin gene-related peptide (CGRP) Rezeptorantagonisten untersucht. Von einer zeitnahen Zulassungs- und klinischen Anwendungsreife der CGRP-Antagonisten ist nicht auszugehen. Eine mögliche Renaissance ergibt sich für Dihydroergotamin nach oraler Inhalation, da die pulmonale Absorption nebenwirkungsärmer als die gastroenterale oder i.m. -Gabe ist. Zur Durchbrechung schwerer Migräneattacken ist die i.v. -Gabe von Valproat der i.v. -Gabe von ASS bezüglich der Wirksamkeit vergleichbar. Therapeutische Ansätze zur Durchbrechung der Migräneaura über eine Inhibition der kortikalen spreading depression mittels transkranieller Magnetstimulation, Gleichstromstimulation oder Verabreichung eines Gap-Junktion-Modulators werden in Tierversuchen als auch klinischen Studien verfolgt. Genetische Assoziationsstudien weisen auf eine besondere Rolle von Glutamat in der Auraentstehung hin. Zur Prävention der Migränechronifizierung einer episodischen Migräne sollten Komorbiditäten anamnestiziert und mitbehandelt werden. Eine Kombinationsbehandlung von Topiramat mit Propranolol ist in der Behandlung der chronischen Migräne der alleinigen Gabe von Topiramat nicht überlegen. Amitriptylin ist bei chronischer Migräne wirksam; Levetiracetam ist nicht wirksam. Bei medikamentöser Therapierefraktärität der chronischen Migräne kann die lokale i.m. -Infiltration mit Botulinumtoxin Typ A in spezifische Kopf-/Nackenmuskelbereiche eine zugelassene Therapieoption darstellen. Die Anwendung eines invasiven neuromodulatorischen Verfahrens mit bilateraler N. occipitalis major Stimulation sollte bei sehr strenger Indikationsstellung unter konsequenter Beachtung sämtlicher Ausschlusskriterien lediglich spezialisierten Zentren vorbehalten bleiben.
Child-operated telepresence robot: A field trial connecting classrooms between Australia and Japan

This paper reports the research outcome of a JST PRESTO project “Linking children across the world through telerobotics (2009-2013). ” The project explored the use of child-operated telepresence robot systems for the purpose of facilitating international communication between distant classrooms. In particular, it was revealed that young children who could not communicate well with speakers of different languages over conventional video conference services could establish and maintain communication using the telepresence robot system developed by this project. Together with a control experiment to clarify its effectiveness, an international field trial that connected remote classrooms between Australia and Japan was conducted.
Understanding gaze and scrolling strategies in text consumption tasks

Scrolling is an integral part of our everyday computing experience, and many techniques and devices have been developed to enhance scrolling. We have conducted an 18 participant user study to understand how users' gaze position and scrolling strategies are coordinated. Our data showed that people scrolled within preferred reading regions of the screen. Scrolling patterns were also influenced by document structure, with most scrolling occurring at the intersection between paragraphs, in order to bring new text into the preferred reading region. We conclude with the implications of our findings with a new gaze-enhanced scrolling technique aimed to support behaviors evident in manual scrolling.
The ZEW Combined Microsimulation-CGE Model: Innovative Tool for Applied Policy Analysis

This contribution describes the linkage of microsimulation models and computable general equilibrium (CGE) models using two already established models called "STSM" and "PACE-L" used by the Centre for European Economic Research. This state of the art research method for applied policy analysis combines the advantages of both model types: On the one hand, microsimulation models allow for detailed labor supply and distributional effects due to policy measures, as individual household data is used. On the other hand, by using a general equilibrium framework, labour market responses, such as wage and labour demand reactions are taken into account.
Realistic CG Stereo Image Dataset With Ground Truth Disparity Maps

Stereo matching is one of the most active research areas in computer vision. While a large number of algorithms for stereo correspondence have been developed, research in some branches of the field has been constrained due to the few number of stereo datasets with ground truth disparity maps available. Having available a large dataset of stereo images with ground truth disparity maps would boost the research on new stereo matching methods, for example, methods based on machine learning. In this work we develop a large stereo dataset with ground truth disparity maps using highly realistic computer graphic techniques. We also apply some of the most common stereo matching techniques to our dataset to confirm that our highly realistic CG stereo images remain as challenging as real-world stereo images. This dataset will also be of great use for camera tracking algorithms, because we provide the exact camera position and rotation in every frame.
Muslim fundamentalism : the case of Sayyid Qutb : defining fundamentalism and religious conservatism in South Africa

This paper deals with the concept of Muslim Fundamentalism and places Sayyid Qutb within this broad context. The paper discusses two key concepts of Qutb's fundamentalism, namely jihad (struggle) and jahilliyyah (ignorance). Qutb introduced a new understanding of ignorance, which originally referred to non-Muslims, but which for Qutb can also refer to those Muslims in government who do not live by the laws of God (Shari'ah). The paper also seeks to examine his last work, Milestones, which led to his death-sentence in 1960 by the Gamal abd al-Nasr regime of Egypt. There is no doubt that the impact of Qutb's thought is still felt today, and some would even argue that he is the main inspiration for contemporary Islamic terrorism.
Altered distribution of intraglomerular immune complexes in C3‐deficient mice

We have studied the role of complement in a model of glomerular inflammation induced by the in situ formation of immune complexes along the glomerular basement membrane. In C3‐deficient mice, produced by homologous recombination, immune complex formation occurs initially in the subendothelial site and progresses slowly to the subepithelial position, whereas wild‐type mice do not develop subendothelial deposits. In addition, the accumulation of electron‐dense deposits is greater in the complement‐deficient mice. Complement therefore influences glomerular handling of immune complexes, possibly because of changes in the physiochemical characteristics of the immune complexes. However, despite evidence of complement activation in the wild‐type mice, as demonstrated by immunohistochemical detection of C3, C4 and C9, the degree of proteinuria was similar in C3‐deficient mice. We conclude that, although complement is required for the normal glomerular metabolism of immune complexes, other, complement‐independent, factors are involved in the generation of glomerular injury in this model.