Miracle-dz/UniFAR-FTUs huggingface dataset:
Expandable metallic stent placement in patients with benign esophageal strictures: results of long-term follow-up.

PURPOSE To evaluate the long-term effectiveness of expandable esophageal metallic stents in benign esophageal strictures. MATERIALS AND METHODS The authors performed long-term follow-up of 14 expandable metallic stents in 12 patients (aged 16-72 years) with benign esophageal strictures. All 12 patients had initially undergone placement of one stent; two patients received an additional stent because of recurrent dysphagia. RESULTS No procedural complications occurred. Delayed complications occurred in all patients. New strictures formed in six stents (five patients), migration occurred in seven stents (six patients), and both migration and formation of new strictures occurred in one stent (one patient). New stricture formation caused recurrence of dysphagia and necessitated further treatment. Three of four stents that migrated within 2 months after placement but none of the four stents that migrated more than 2 months after placement caused recurrence of dysphagia. Six patients died of unrelated causes 6-20 months after stent placement. The remaining six patients are still alive 24-48 (mean, 35) months after stent placement. CONCLUSION The long-term effectiveness of expandable metallic stents in benign esophageal strictures is not encouraging because of the high delayed-complication rate. That the patients with migration showed improvement of dysphagia, however, may warrant further investigation of temporary placement of a retrievable covered stent.
The psychological significance of humility

Abstract Humility is a virtue with a rich and varied past. Its benefits and pitfalls – indeed, its status as a virtue – have been debated by philosophers and theologians. Recently, psychologists have entered into the dialectic, with a small but growing body of empirical research at their disposal. We will discuss this research on humility, including our own recent contributions. Our goal is to shed light on the following three important questions: First, what is humility? Second, why we should care about being humble? Finally, are there constructive steps we can take to induce people to adopt more humble at titudes towards themselves and others? In the process of answering these questions, we will consider the major empirical accounts of humility in the literature, highlight their primary difficulties, and then introduce a new account that cuts through the confusion, getting to the core of what we take humility to be.
Complete Genome Sequence of Pig-Tailed Macaque Rhadinovirus 2 and Its Evolutionary Relationship with Rhesus Macaque Rhadinovirus and Human Herpesvirus 8/Kaposi's Sarcoma-Associated Herpesvirus

ABSTRACT Two rhadinovirus lineages have been identified in Old World primates. The rhadinovirus 1 (RV1) lineage consists of human herpesvirus 8, Kaposi's sarcoma-associated herpesvirus (KSHV), and closely related rhadinoviruses of chimpanzees, gorillas, macaques and other Old World primates. The RV2 rhadinovirus lineage is distinct and consists of closely related viruses from the same Old World primate species. Rhesus macaque rhadinovirus (RRV) is the RV2 prototype, and two RRV isolates, 26-95 and 17577, were sequenced. We determined that the pig-tailed macaque RV2 rhadinovirus, MneRV2, is highly associated with lymphomas in macaques with simian AIDS. To further study the role of rhadinoviruses in the development of lymphoma, we sequenced the complete genome of MneRV2 and identified 87 protein coding genes and 17 candidate microRNAs (miRNAs). A strong genome colinearity and sequence homology were observed between MneRV2 and RRV26-95, although the open reading frame (ORF) encoding the KSHV ORFK15 homolog was disrupted in RRV26-95. Comparison with MneRV2 revealed several genomic anomalies in RRV17577 that were not present in other rhadinovirus genomes, including an N-terminal duplication in ORF4 and a recombinative exchange of more distantly related homologs of the ORF22/ORF47 interacting glycoprotein genes. The comparison with MneRV2 has revealed novel genes and important conservation of protein coding domains and transcription initiation, termination, and splicing signals, which have added to our knowledge of RV2 rhadinovirus genetics. Further comparisons with KSHV and other RV1 rhadinoviruses will provide important avenues for dissecting the biology, evolution, and pathology of these closely related tumor-inducing viruses in humans and other Old World primates. IMPORTANCE This work provides the sequence characterization of MneRV2, the pig-tailed macaque homolog of rhesus rhadinovirus (RRV). MneRV2 and RRV belong to the rhadinovirus 2 (RV2) rhadinovirus lineage of Old World primates and are distinct but related to Kaposi's sarcoma-associated herpesvirus (KSHV), the etiologic agent of Kaposi's sarcoma. Pig-tailed macaques provide important models of human disease, and our previous studies have indicated that MneRV2 plays a causal role in AIDS-related lymphomas in macaques. Delineation of the MneRV2 sequence has allowed a detailed characterization of the genome structure, and evolutionary comparisons with RRV and KSHV have identified conserved promoters, splice junctions, and novel genes. This comparison provides insight into RV2 rhadinovirus biology and sets the groundwork for more intensive next-generation (Next-Gen) transcript and genetic analysis of this class of tumor-inducing herpesvirus. This study supports the use of MneRV2 in pig-tailed macaques as an important model for studying rhadinovirus biology, transmission and pathology.
The classmates social isolation questionnaire (CSIQ): An initial validation

Abstract Social Isolation means having a lack of social contacts. This study reports a first validation of a brief self-report measure, the Classmates Social Isolation Questionnaire (CSIQ). The CSIQ is a questionnaire for children which assesses social isolation from classmates within the classroom as well as outside school. Data was based on a nationally representative sample of 26,670 Italian fifth grade students. Through exploratory and confirmatory factor analyses the bidimensional structure of the scale was established. The CSIQ showed measurement invariance both across gender and across groups with different immigrant backgrounds.Various tests of criterion validity had positive results and the CSIQ appears to be a valid and time-efficient instrument that can make a contribution to the study of social isolation and correlated factors.
Attack of the clones: reproductive interference between sexuals and asexuals in the Crepis agamic complex

Abstract Negative reproductive interactions are likely to be strongest between close relatives and may be important in limiting local coexistence. In plants, interspecific pollen flow is common between co‐occurring close relatives and may serve as the key mechanism of reproductive interference. Agamic complexes, systems in which some populations reproduce through asexual seeds (apomixis), while others reproduce sexually, provide an opportunity to examine effects of reproductive interference in limiting coexistence. Apomictic populations experience little or no reproductive interference, because apomictic ovules cannot receive pollen from nearby sexuals. Oppositely, apomicts produce some viable pollen and can exert reproductive interference on sexuals by siring hybrids. In the Crepis agamic complex, sexuals co‐occur less often with other members of the complex, but apomicts appear to freely co‐occur with one another. We identified a mixed population and conducted a crossing experiment between sexual diploid C. atribarba and apomictic polyploid C. barbigera using pollen from sexual diploids and apomictic polyploids. Seed set was high for all treatments, and as predicted, diploid–diploid crosses produced all diploid offspring. Diploid–polyploid crosses, however, produced mainly polyploidy offspring, suggesting that non‐diploid hybrids can be formed when the two taxa meet. Furthermore, a small proportion of seeds produced in open‐pollinated flowers was also polyploid, indicating that polyploid hybrids are produced under natural conditions. Our results provide evidence for asymmetric reproductive interference, with pollen from polyploid apomicts contributing to reduce the recruitment of sexual diploids in subsequent generations. Existing models suggest that these mixed sexual–asexual populations are likely to be transient, eventually leading to eradication of sexual individuals from the population.
Membrane fusion mediated by herpesvirus glycoproteins: the paradigm of varicella‐zoster virus

Varicella‐zoster virus (VZV) is well known for its propensity to cause polykaryons (syncytia) in the vesicles within infected skin. Similarly in cultured cells, VZV induces extensive syncytial formation by virus‐mediated cell‐to‐cell fusion. Statistical analyses of fusion parameters demonstrated three‐way interactive effects among all three tested variables (incubation temperature, cell type and virus strain). For example, fusion was greatly enhanced at 33°C vs 37°C; also fusion was pronounced in epidermal cells but negligible in fibroblast cells. As with all herpesviruses, VZV gH was a major fusogen. VZV cell fusion was inhibited by antibody to gH, but surprisingly was enhanced by antibody to gE. Other evidence implicating a role for VZV gE in the fusion process was provided by two mutant viruses, in which gE cell surface expression was enhanced. Under transfection conditions, VZV fusion formation occurred after expression of the gH/gL complex; in contrast, pseudorabies virus requires expression of gH, gL and gB, while the herpes simplex virus (HSV) types 1 and 2 require the quartet of gH, gL, gB and gD. VZV has no gD gene and no apparent gD functional homologue. On the other hand, VZV gE exerts a greater effect than HSV gE on membrane fusion. Taken together, the data in this review suggest that VZV has evolved viral glycoprotein machinery more geared toward cell‐to‐cell fusion (fusion‐from‐within) than toward virus‐to‐cell fusion (entry/fusion‐from‐without), as a means for syncytium formation within the human epidermis. Copyright © 2003 John Wiley & Sons, Ltd.
Molecular thanatopsis: a discourse on the BCL2 family and cell death.

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Respiratory syncytial virus: Changes in prevalence of subgroups A and B among Argentinian children, 1990–1996

The frequency of respiratory syncytial virus (RSV) and the distribution of subgroups A and B strains during 7 consecutive years (1990–1996) were examined in two cities of Argentina. Nasopharyngeal aspirates from 1,304 children less than 2 years of age hospitalized with acute lower respiratory infection were studied by indirect immunofluorescence. RSV was detected in 352 cases (26.9%), and the peak activity was observed in midwinter. Subgroup characterization was performed with two monoclonal antibodies against the F protein on nasopharyngeal aspirate smears. Of 195 samples, 174 (89.2%) were identified as subgroup A strains and 21 (10.8%) as subgroup B. Both strains cocirculated during 5 of 7 years studied with subgroup A predominating. Subgroup A occurred at least 8 times as often in all years except for 1994–1995. Children infected by subgroup A were younger than those infected by subgroup B (P < 0.05). The association of subgroup A infection with bronchiolitis and subgroup B with pneumonia was statistically significant (P < 0.03). J. Med. Virol. 61:275–279, 2000. © 2000 Wiley‐Liss, Inc.
The polyamine spermine induces the unfolded protein response via the MAPK cascade in Arabidopsis

In Arabidopsis three basic region leucine zipper (bZIP) transcription factor genes, bZIP17, bZIP28, and bZIP60, play crucial roles in the unfolded protein response (UPR). Previously we found that bZIP60 is one of the spermine-induced genes. Consequently we further investigated the response of all the three bZIP genes to spermine. Expression of bZIP17, bZIP28, and bZIP60, and also their target genes was activated by spermine application as well as in plants with elevated endogenous spermine levels. Furthermore, spermine activated the splicing of the bZIP60 transcript mediated by the ribonuclease activity of inositol-requiring enzyme 1 and also recruited bZIP17 and bZIP60 proteins from endoplasmic reticulum to nucleus. We therefore propose that spermine is a novel UPR inducer. Moreover, induction of UPR by spermine required calcium-influx to the cytoplasm and the genes for mitogen-activated protein kinase kinase 9 (MKK9), mitogen-activated protein kinase 3 (MPK3) and MPK6. The result indicates that spermine-induced UPR is mediated by the MKK9-MPK3/MPK6 cascade in Arabidopsis.
The role of simulation in intertemporal choices

One route to understanding the thoughts and feelings of others is by mentally putting one's self in their shoes and seeing the world from their perspective, i.e., by simulation. Simulation is potentially used not only for inferring how others feel, but also for predicting how we ourselves will feel in the future. For instance, one might judge the worth of a future reward by simulating how much it will eventually be enjoyed. In intertemporal choices between smaller immediate and larger delayed rewards, it is observed that as the length of delay increases, delayed rewards lose subjective value; a phenomenon known as temporal discounting. In this article, we develop a theoretical framework for the proposition that simulation mechanisms involved in empathizing with others also underlie intertemporal choices. This framework yields a testable psychological account of temporal discounting based on simulation. Such an account, if experimentally validated, could have important implications for how simulation mechanisms are investigated, and makes predictions about special populations characterized by putative deficits in simulating others.
Application of ego depletion theory to leader helping: The dark side of reactive helping

APPLICATION OF EGO DEPLETION THEORY TO LEADER HELPI NG: THE DARK SIDE OF REACTIVE HELPING By Klodiana Lanaj Research indicates that leaders are often approache d by followers with help requests for task-related and personal problems. In addition, theories of leadership recognize that providing support and encouragement to followers is an important leader behavior. Little research, however, has examined ho w elping followers may affect leaders despite theoretical arguments that helping may deplete self-regulatory resources. Drawing on Ego Depletion Theory, I propose that lea der reactive helping – defined as helping in response to direct requests for assistan ce by followers depletes leaders’ selfregulatory resources. I also propose that helping w ith personal problems is more depleting than helping with task-related problems. Depletion, on the other hand, is expected to harm leaders’ work engagement and creat ivity because these activities require self-regulatory resources. Helping role per ceptions and prosocial motivation are proposed to moderate the effects of reactive helpin g on depletion; whereas prosocial impact and trait self-control are proposed to moder ate the effects of state depletion on work engagement and creativity. An experience sampl ing methodology is utilized to test these research questions in a sample of middle and se ior managers.
Natural Killer Cells Modulation in Hematological Malignancies

Hematological malignancies (HM) treatment improved over the last years resulting in increased achievement of complete or partial remission, but unfortunately high relapse rates are still observed, due to remaining minimal residual disease. Therefore, sustainment of long-term remission is crucial, using either drug maintenance treatment or by boosting or prolonging an immune response. Immune system has a key role in tumor surveillance. Nonetheless, tumor-cells evade the specific T-lymphocyte mediated immune surveillance using many mechanisms but especially by the down-regulation of the expression of HLA class I antigens. In theory, these tumor-cells lacking normal expression of HLA class I molecules should be destroyed by natural killer (NK) cells, according to the missing-self hypothesis. NK cells, at the frontier of innate and adaptive immune system, have a central role in tumor-cells surveillance as demonstrated in the setting of allogenic stem cell transplantation. Nevertheless, tumors develop various mechanisms to escape from NK innate immune pressure. Abnormal NK cytolytic functions have been described in many HM. We present here various mechanisms involved in the escape of HM from NK-cell surveillance, i.e., NK-cells quantitative and qualitative abnormalities.
J ul 2 00 1 Symmetries , Matrices , and de Sitter Gravity

Using simple algebraic methods along with an analogy to the BFSS model, we explore the possible (target) spacetime symmetries that may appear in a matrix description of de Sitter gravity. Such symmetry groups could arise in two ways, one from an “IMF” like construction and the other from a “DLCQ” like construction. In contrast to the flat space case, we show that the two constructions will lead to different groups, i.e. the Newton-Hooke group and the inhomogeneous Euclidean group (or its algebraic cousins). It is argued that matrix quantum mechanics based on the former symmetries look more plausible. Then, after giving a detailed description of the relevant one particle dynamics, a concrete Newton-Hooke matrix model is proposed. The model naturally incorporates issues such as holography, UV-IR relations, and fuzziness, for gravity in dS4. We also provide evidence to support a possible phase transition. The lower temperature phase, which corresponds to gravity in the perturbative regime, has a Hilbert space of infinite dimension. In the higher temperature phase where the perturbation theory breaks down, the dimension of the Hilbert space may become finite.
On Wilf Equivalence for Alternating Permutations

In this paper, we obtain several new classes of Wilf-equivalent patterns for alternating permutations. In particular, we prove that for any nonempty pattern $\tau$, the patterns $12\ldots k\oplus\tau$ and $k\ldots 21\oplus\tau$ are Wilf-equivalent for alternating permutations, paralleling a result of Backelin, West, and Xin for Wilf equivalence for permutations.
[Effects of enhanced external counterpulsation in atherosclerosis and NF-kappaB expression: a pig model with hypercholesterolemia].

OBJECTIVE To study the effects of enhanced external counterpulsation (EECP) on the vascular morphology, and endothelial function using experimentally induced hypercholesterolemic pigs. METHODS Thirty five male pigs were randomly divided into three groups: 7 normal control animals, 11 hypercholesterolemic animals, and 17 hypercholesterolemic animals receiving EECP. Serum cholesterol was measured. The coronary arteries and aortas were sampled for histopathologic and ultrastructural examination. The NF-kappaB protein expression of porcine coronary arteries was investigated by immunofluorescence. RESULTS Compared with the normal controls, serum cholesterol levels were significantly higher in the hypercholesterolemic animals with or without EECP. The plaque/intimal area ratio of the aorta decreased significantly in animals receiving EECP [(3.33 +/- 2.40)%, versus (12.03 +/- 7.12)% in those without EECP, P < 0.05]. Lipid deposition, endothelial damage and proliferation of smooth muscle cells were less severe in animals receiving EECP than those not. Moreover, activation and expression of NF-kappaB also decreased significantly (P < 0.05) in animals receiving EECP. CONCLUSIONS EECP improves the morphology and function of vascular endothelium, and retards the development and progression of atherosclerosis, likely through the inhibition of NF-kappaB signaling pathway.
A 64-fJ/Conv.-Step Continuous-Time  $\Sigma \Delta$ Modulator in 40-nm CMOS Using Asynchronous SAR Quantizer and Digital  $\Delta \Sigma$ Truncator

A third-order single-loop continuous-time sigma-delta modulator (CTSDM) with 6-bit asynchronous successive approximation register (ASAR) quantizer and digital ΔΣ truncator for WCDMA/GSM/EDGE cellular systems is presented. The proposed ASAR-based quantizer reduces the area and power of the modulator dramatically by utilizing the digital truncation technique. By using the 6-bit ASAR quantizer, the sampling frequency is lowered, which reduces the design efforts not only in system level but also in the modulator. In addition, the ac-coupled push-pull stage is employed to improve the high-frequency driving capability of the first integrator. Sampling at 65 MHz, the modulator achieves 83.4 dB dynamic range (DR) and 80/79.6 dB peak SNR/SNDR with 1.92 MHz bandwidth in WCDMA mode. In GSM/EDGE mode, the DR is 96.2 dB. Fabricated in 40-nm CMOS, the modulator occupies 0.051 mm 2 and consumes 1.91 mW from a 1.2-V supply. A 64fJ/conv. -step figure of merit is achieved.
Chromosomal Copy Number Alterations Are Associated with Persistent Lymph Node Metastasis After Chemoradiation in Locally Advanced Rectal Cancer

BACKGROUND: Lymph node metastasis is an important indicator of oncologic outcome for patients with rectal cancer. Identifying predictive biomarkers of lymph node metastasis could therefore be clinically useful. OBJECTIVE: The aim of this study was to assess whether chromosomal copy number alterations can assist in predicting persistent lymph node metastasis in patients with locally advanced rectal cancer treated with preoperative chemoradiation therapy. DESIGN: This is a nonrandomized, prospective phase II study. SETTING: This study took place in a multi-institutional setting. PATIENTS: Ninety-five patients with stage II (cT3-4, cN0) or stage III (any cT, cN1-2) rectal cancer were included. INTERVENTION: Patients were treated with preoperative chemoradiation therapy followed by total mesorectal excision. Pretreatment biopsy tumor DNA and surgical margin control DNA were extracted and analyzed by oligonucleotide array-based comparative genomic hybridization. Chromosomal copy number alterations were correlated with persistent lymph node metastasis. Finally, a model for predicting persistent lymph node metastasis was built. MAIN OUTCOME MEASURES: The primary outcomes assessed were whether chromosomal copy number alterations are associated with persistent lymph node metastasis in patients with rectal cancer and the accuracy of oligonucleotide array-based comparative genomic hybridization for predicting lymph node metastasis. RESULTS: Twenty-five of 95 (26%) patients had lymph node metastasis after chemoradiation. Losses of 28 chromosomal regions, most notably in chromosome 4, were significantly associated with lymph node metastasis. Our predictive model contained 65 probes and predicted persistent lymph node metastasis with 68% sensitivity, 93% specificity, and positive and negative predictive values of 77% and 89%. The use of this model accurately predicted lymph node status (positive or negative) after chemoradiation therapy in 82 of 95 patients (86%). LIMITATIONS: The patient cohort was not completely homogeneous, which may have influenced their clinical outcome. In addition, although we performed rigorous, statistically sound internal validation, external validation will be important to further corroborate our findings. CONCLUSIONS: Copy number alterations can help identify patients with rectal cancer who are at risk of lymph node metastasis after chemoradiation.