Miracle-dz/UniFAR-FTUs huggingface dataset:
Specification of business rules for the development of hospital alarm system: application to the pharmaceutical validation

Although clinical alarm systems are part of the knowledge management setting within healthcare organisations, modelling of business processes related to decision support and knowledge representation of decision rules are seldom described. We propose a customization of the Unified Process that takes into account user requirements for clinical alarm systems by introducing the Semantics of Business Vocabulary and Business Rules (SBVR). This methodology was applied to the design and implementation of a clinical alarm system for pharmaceutical validation at the European Hospital Georges Pompidou (HEGP). Rules were implemented using the IlogJRules Business Rule Management System. We produced 3 business rules patterns and 427 instances of rules. As SBVR is close to natural language, pharmacists were able to understand rules and participate to their design.
Synchronization issue for optical camera communications

When mentioning about camera, we just think about the picture characteristics such the quality, the resolution. Besides, it will be also the promising technique for communication issue which can be called as optical wireless communication (OWC). The research about OWC has been pushed from these years. However the synchronization still is one of the most considerations. In this paper we analyze and propose synchronization scheme for frequency shift ON-OFF keying OWC system.
Altered Topological Organization of Cortical Network in Adolescent Girls with Idiopathic Scoliosis

Adolescent idiopathic scoliosis (AIS) is a multifactorial disease affecting approximately 1–4% of teenagers especially girls at the age of 10–16, but its etiopathogenesis remains uncertain. Previous study has revealed that the cortical thickness in AIS patients is different from that in normal controls. Cortical thickness measurements are known to be strongly correlated between regions that are axonally connected. Hence, a hypothesis is proposed to study the possibility to demonstrate abnormal structural network revealed by cortical thickness in AIS patients. The aim of the study is to investigate abnormalities in the organization of the brain cortical network in AIS patients. This study included 42 girls with severe idiopathic scoliosis (14.7±1.3 years old) and 41 age-matched normal controls (NC, 14.6±1.4 years old). The brain cortex was partitioned into 154 cortical regions based on gyral and sulcal structure. The interregional connectivity was measured as the statistical correlations between the regional mean thicknesses across the subjects. We employed the graph theoretic analysis to examine the alteration in interregional correlation, small-world efficiency, hub distribution, and regional nodal characteristics in AIS patients. We demonstrated that the cortical network of AIS patients fully preserved the small-world architecture and organization, and further verified the hemispheric asymmetry of AIS brain. Our results indicated increased central role of temporal and occipital cortex and decreased central role of limbic cortex in AIS patients compared with controls. Furthermore, decreased structural connectivity between hemispheres and increased connectivity in several cortical regions were observed. The findings of the study reveal the pattern of structural network alteration in AIS brain, and would help in understanding the mechanism and etiopathogenesis of AIS.
A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning

CRM1 is a highly conserved, RanGTPase-driven exportin that carries proteins and RNPs from the nucleus to the cytoplasm. We now explored the cargo-spectrum of CRM1 in depth and identified surprisingly large numbers, namely >700 export substrates from the yeast S. cerevisiae, ≈1000 from Xenopus oocytes and >1050 from human cells. In addition, we quantified the partitioning of ≈5000 unique proteins between nucleus and cytoplasm of Xenopus oocytes. The data suggest new CRM1 functions in spatial control of vesicle coat-assembly, centrosomes, autophagy, peroxisome biogenesis, cytoskeleton, ribosome maturation, translation, mRNA degradation, and more generally in precluding a potentially detrimental action of cytoplasmic pathways within the nuclear interior. There are also numerous new instances where CRM1 appears to act in regulatory circuits. Altogether, our dataset allows unprecedented insights into the nucleocytoplasmic organisation of eukaryotic cells, into the contributions of an exceedingly promiscuous exportin and it provides a new basis for NES prediction. DOI: http://dx.doi. org/10.7554/eLife.11466. 001
Incidence of impacted and supernumerary teeth-a radiographic study in a North Greek population.

OBJECTIVES The aim of the present study was to investigate the prevalence of impacted and supernumerary teeth, apart from third molars. STUDY DESIGN This was a retrospective study of 1.239 panoramic radiographs taken of patients who presented to the Department of Dentoalveolar Surgery, Implantology and Radiology at the School of Dentistry of the Aristotle University of Thessaloniki, Greece between 1991 and 1999. The panoramic radiographs and dental records were reviewed in order to determine whether there were impacted or supernumerary teeth. Observations were also made on the space in dentition, corresponding to the position of each impacted tooth, the lack of space for tooth eruption, transmigration, retained primary teeth or prosthetic restoration. RESULTS A total of 170 (13.7%) patients presented with at least one impacted tooth. None of them had an impacted incisor. Impacted canines were the most prevalent dental anomaly (8.8%), followed by impacted premolars (2.2%). Supernumerary teeth (1.8%) and impacted molars (1%) were the least common anomalies. Among the 225 impacted teeth, the most frequently affected teeth were the canines (59.6%), followed by premolars (19.1%), and supernumerary teeth (15.1%), while the incidence of impacted molars was substantially lower (6.2%). CONCLUSIONS The most frequently impacted teeth were the maxillary canine, the second mandibular premolar and the second mandibular molar. The majority of the supernumerary teeth consisted of mesiodens. There was space in the dentition of each impacted tooth in 29.3% of the cases examined; there was a retained primary tooth in 25.1%, and a prosthetic restoration had been constructed in 24%. Insufficient space for the eruption of the impacted tooth and transmigration was observed in 17.3% and 4.2% of the cases, respectively.
H Dqf of Cement

A 1 H double quantum filtered NMR study of water in cement pastes. Abstract The results of a 1 H Double Quantum Filtered (DQF) Nuclear Magnetic Resonance (NMR) study of water in cement pastes are reported. It is shown that the DQF signal increases with curing time and in sympathy with the loss of mobile single quantum signal suggesting strongly that signal from 1 H in chemically-combined and strongly confined water is selectively observed. The DQF signal in white cement comprises at least two components: the first is assigned to Portlandite (Ca(OH) 2); the second is assigned to water in the planar, nano-metre wide, calcium-silicate-hydrate (C-S-H) gel pores. The pore water signal is significantly broader than that expected for bound water. The width is interpreted in terms of the water undergoing a two dimensional walk in the vicinity of Fe 3+ impurities. A simple model is presented and found to be consistent with experiment and the known Fe 3+ concentration. In grey cements a third component is identified and associated with Fe rich phases. The analysis places a lower bound on the lateral extent of planar C-S-H pores. The change of DQF signal components upon drying a sample mirrors the loss of the single quantum components observed in a parallel study.
Predictors of empathy in women social workers

Summary This study explored the manifestation of reflective ability, emotional intelligence and empathy in 120 women social workers in Tiruchirappalli, India. A cross-sectional quantitative design was used and the Emotional Intelligence Scale, Groningen Reflective Ability Scale and the Empathy Assessment Index were administered to assess the manifestation of these dimensions. Multiple regression analysis was used to identify predictors of empathy. Findings Based on mean scores, the majority of respondents were classified as being ‘high’ in terms of emotional intelligence and reflective ability. Respondents of different age groups showed a significant difference in terms of the manifestation of empathy. Age, self-reflection and appraisal and expression of emotions were extracted as significant predictors of empathy. Application The article discusses the importance of these professional attributes for effective practice and the role of academic institutions and social work organisations in fostering the development of these dimensions in social work practitioners.
Multi-Adjoint Algebras Versus Extended-Order Algebras

Adjoint triples are an interesting generalization of t-nor ms and their residuated implications, since they increase t he flexibility in the framework where they are used. Following t he same motivation of adjoint triples, in order to reduce the mathematical requirements for the computation, extended-order algebras are studied. Extended-order algebras are implicative algebras that generalize the integral residuated structures. In this paper, adjoint triples will be related to the operators considered in exten ded-order algebras. Furthermore, a comparison between adjoint negations and the negations introduced in extended-order algebras is presented.
Sum Rate Maximizing Superposition Coding Scheme for a Two-User Wireless Relay System

A wireless system is considered where users are served in Downlink (DL) by one Base Station (BS) and one Relay Station (RS). A scheme based on Superposition Coding (SC) is proposed, where two users are served by three superposed layers that take advantage of the three available links for maximizing sum rate. With the derived optimal allocation parameters, our scheme outperforms benchmark schemes for sum-rate and fairness, making it very efficient for scheduling multiple users.
Modulation of TNF-α Secretion in Peripheral Blood Mononuclear Cells by Cocoa Flavanols and Procyanidins

Epidemiological reports have suggested that the consumption of foods rich in flavonoids is associated with a lower incidence of certain degenerative diseases, including cardiovascular disease. Flavanols and their related oligomers, the procyanidins CFP, isolated from cocoa can modulate the production and level of several signaling molecules associated with immune function and inflammation in vitro, including several cytokines and eicosanoids. To further elucidate the potential immuno-modulatory functions of flavanol-rich cocoa, the present investigation examined whether isolated CFP fractions (monomers through decamers) influence the secretion of tumor necrosis factor-α (TNF-α) from resting and phytohemagluttinin (PHA)-stimulated human peripheral blood mononuclear cells (PBMC). We used an in vitro culture system where PBMC from 14 healthy subjects were introduced to individual CFP fractions for 72 h prior to measuring the levels of TNF-α released. The intermediate-sized CFP fractions (tetramers through octamers) were the most active on resting cells, causing a 3–4 fold increase in TNF-α relative to media baseline. The monomers and dimers were the least stimulatory of the fractions tested, displaying a 42 and 31% increase, respectively, over media control, whereas the trimers, nonamers and decamers showed an intermediate stimulation of this cytokine. In the presence of PHA, the intermediate-sized CFP fractions again were the most active, enhancing TNF-α secretion in the range of 48–128% relative to the PHA control. The monomers and dimers were slightly inhibitory (–1.5 and –15%, respectively), while trimers, nonamers and decamers stimulated moderate increases in TNF-α levels (13, 19 and 15%, respectively). The above results lend support to the concept that CFP can be immunomodulatory. The stimulation of TNF-α secretion may contribute to the putative beneficial effects of dietary flavanoids against microbial infection and tumorigenesis.
Symbolic-based motion control method for wheeled mobile robots

A symbolic-based motion control method for wheeled mobile robots is put forward in this paper. Wheeled mobile robots, which are characterized by the nonholonomic constraints, are particularly difficult to control since real environment may be full of obstacles. Traditional methods have to resort to analysis and design at the level of individual sensors and actuators. As a result, the richness of the set of mappings from sensor to actuator signals constitutes a great challenge in determining a suitable control law to steer the wheeled mobile robot. In view of those considerations, a symbolic-based control method is presented, in which control procedures have a natural, linguistic flavor. In this method, different control procedures can be generated from a finite set composed of symbols which correspond to different control actions. It is obvious that this method allows one to design feedback control laws at the level of strings and primitives, rather than at the level of sensors and actuators. Simulation results show that the proposed method is effective for the control of wheeled mobile robots.
Co-selection of metal and antibiotic resistance in the gut microbial community of the Mummichog fish (Fundulus heteroclitus)

ii Acknowledgements iv List of Tables vii List of Figures ix Preface x Chapter 1 – Introduction 1 Chapter 2 – Co-selection of Mercury and Multiple Antibiotic Resistances in Bacteria Exposed to Mercury in the Fundulus heteroclitus Gut Microbiome 11 Chapter 3 – Whole Genome Sequences to Assess the Link Between Antibiotic and Metal Resistance in Three Coastal Marine Bacteria Isolated from the Mummichog (Fundulus heteroclitus) Gastrointestinal Tract 32 Chapter 4 – Genome-Facilitated Discovery of RND Efflux Pump-Mediated Resistance to Cephalosporins in Vibrio spp. Isolated form the Mummichog Fish Gut 53 Chapter 5 – The Role of Efflux Pumps in Resistance to Arsenate and Antibiotics in Shewanella sp. BC20 75 Summary and Concluding Remarks 97 Appendix A – Supplementary Material for Chapter 2 102 Appendix B – Supplementary Material for Chapter 3 118 Appendix C – Supplementary Material for Chapter 4 123 Appendix D – Supplementary Material for Chapter 5 125 Appendix E – Supplementary Excel File 127 References 128
Resistance of Leishmania donovani to Sodium Stibogluconate Is Related to the Expression of Host and Parasite γ-Glutamylcysteine Synthetase

ABSTRACT Sequencing studies showed that the γ-glutamylcysteine synthetase (γ-GCS) heavy chain genes from sodium stibogluconate (SSG)-resistant (SSG-R) and SSG-susceptible (SSG-S) Leishmania donovani strains were identical, indicating that SSG resistance was related to quantitative differences in γ-GCS expression rather than gene interstrain polymorphisms. In vitro infection of murine macrophages with the SSG-R strain, but not the SSG-S strain, down regulated expression of host γ-GCS, which would result in a reduction in intramacrophage glutathione (GSH) levels and promote an oxidative intramacrophage environment. This would inhibit, or minimize, the reduction of SSG pentavalent antimony to its more toxic trivalent form. Macrophage studies showed that the SSG-R strain expressed higher levels of γ-GCS compared to the SSG-S strain, which would result in higher GSH levels, giving increased protection against oxidative stress and facilitating SSG efflux. However a similar differential effect on host and parasite γ-GCS expression was not obtained when using tissues from infected mice. In this case γ-GCS expression was organ and strain dependent for both the host and the parasite, indicating that environmental conditions have a profound effect on γ-GCS expression. Consistent with the proposed mechanism from in vitro studies, increasing tissue GSH levels in the presence of SSG by cotreatment of L. donovani-infected mice with SSG solution and GSH incorporated into nonionic surfactant vesicles was more effective in reducing liver, spleen, and bone marrow parasite burdens than monotherapy with SSG. Together, these results indicate that SSG resistance is associated with manipulation of both host and parasite GSH levels by L. donovani.
Computability of the Radon-Nikodym Derivative

We show that a single application of the noncomputable operator EC, which transforms enumerations of sets (in N) to their characteristic functions, suffices to compute the Radon-Nikodym derivative dµ/dλ of a finite measure µ, which is absolutely continuous w.r. t. the σ-finite measure λ. We also give a condition on the two measures (in terms of computability of the norm of a certain linear operator involving the two measures) which is sufficient to compute the derivative.
Common Alzheimer's Disease Risk Variant Within the CLU Gene Affects White Matter Microstructure in Young Adults

There is a strong genetic risk for late-onset Alzheimer's disease (AD), but so far few gene variants have been identified that reliably contribute to that risk. A newly confirmed genetic risk allele C of the clusterin (CLU) gene variant rs11136000 is carried by ∼88% of Caucasians. The C allele confers a 1.16 greater odds of developing late-onset AD than the T allele. AD patients have reductions in regional white matter integrity. We evaluated whether the CLU risk variant was similarly associated with lower white matter integrity in healthy young humans. Evidence of early brain differences would offer a target for intervention decades before symptom onset. We scanned 398 healthy young adults (mean age, 23.6 ± 2.2 years) with diffusion tensor imaging, a variation of magnetic resonance imaging sensitive to white matter integrity in the living brain. We assessed genetic associations using mixed-model regression at each point in the brain to map the profile of these associations with white matter integrity. Each C allele copy of the CLU variant was associated with lower fractional anisotropy—a widely accepted measure of white matter integrity—in multiple brain regions, including several known to degenerate in AD. These regions included the splenium of the corpus callosum, the fornix, cingulum, and superior and inferior longitudinal fasciculi in both brain hemispheres. Young healthy carriers of the CLU gene risk variant showed a distinct profile of lower white matter integrity that may increase vulnerability to developing AD later in life.
Metropolitan-scale taxicab mobility modeling

Taxicabs, as one of the major transportation platforms in metropolises, are of great interest in vehicular communications and networking research. The mobility of taxicabs, determined by driver behaviors and passenger destinations, has attracted a lot of attention in recent years. Among different mobility models, trace-driven taxicab mobility models preserve many details but often bring too much overhead, while simple, random mobility models largely miss the needed social and geographical features. In this paper, we follow a new approach to capture the social behaviors (e.g., transition among regions) and geographical features (e.g., hot spots) of taxicabs in a metropolis, and build a hierarchical taxicab mobility model to strike a better balance between fidelity and tractability. The performance study shows that the synthesized mobility model can well capture the original trace data while being simple and extensible. It also reveals the difference between taxicab and pedestrian mobility, the latter of which is also often used for vehicles in the literature.
Decision-Aiding Transit-Tracker Methodology for Bus Scheduling Using Real Time Information to Ameliorate Traffic Congestion in the Kathmandu Valley of Nepal

The bustling urban environment of Kathmandu Valley is characterized by unprecedented traffic congestion. Due to its bowel-shaped geography, gusty winds rarely remove vehicular emissions from the urban atmosphere, making Kathmandu one of Asia’s most polluted cities, 100th city in global pollution index. Over 500,000 vehicles travel daily on over 1600 km of roads covering over 675 sq·km urban area. Thousands of low occupancy vehicles are added each year to the urban public transit system (UPTS). Kathmandu faces worse and unreliable traffic from the current UPTS mostly with low occupancy vehicles. Around 4.5 million urban denizens, both permanent and transient residents, suffer from unreliable UPTS. Traffic rules and daily transportation schedules are rarely followed, resulting in frequent traffic jams and accidents. Once experienced, visitors try avoiding the UPTS. Tourism, annually contributing almost 8 percent to Nepal’s total annual GDP, also suffers from poor UPTS. Planners, policy makers, and politicians (P-actors) are seeking ways to improve sustainable UPTS to ameliorate stresses to family life and working hours for the urban majority. Aiming to help P-actors, we propose a transit-tracker model that uses real time information (RTI) in mobile phones and web-embedded devices to inform travelers, drivers, government authorities, and sub-admins. We argue that unreliability in the UPTS motivates urban elites to add more low occupancy vehicles, which in turn reduces already shrunken urban spaces and contributes more per capita air pollution than multi-occupancy vehicles. Since mobile and smart phones are capable of processing RTI to generate meaningful information and inform various stakeholders in communicable languages, we argue that replacing low occupancy vehicles with multi-occupancy buses within a Bus Rapid Transit (BRT) system, on main roads with fixed schedules and strict traffic rules, would not only improve UPTS, but also reduce pollution in the Kathmandu Valley.
Imperfect Information and Optimal Monetary Policy ∗

Most of the analysis of optimal monetary policy is conducted with the Calvo model. This paper studies optimal monetary policy when the slow adjustment of the price level is due to imperfect information by decision-makers in firms. We consider two models: a model with exogenous dispersed information and a rational inattention model. In the model with exogenous dispersed information, complete stabilization of the price level is optimal after aggregate productivity shocks but not after markup shocks. By contrast, in the rational inattention model, complete stabilization of the price level is optimal both after aggregate productivity shocks and after markup shocks. Moreover, in the model with exogenous dispersed information, there is no value from commitment to a future monetary policy. By contrast, in the rational inattention model, there is value from commitment to a future monetary policy because then the private sector can trust the central bank that not paying attention to certain variables is optimal. JEL: E3, E5, D8.