Miracle-dz/UniFAR-FTUs huggingface dataset:
An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusion.

OBJECTIVE The detrimental effects of coagulopathy, hypothermia, and acidosis are well described as markers for mortality after traumatic hemorrhage. Recent military experience suggests that a high fresh frozen plasma (FFP):packed red blood cell (PRBC) transfusion ratio improves outcome; however, the appropriate ratio these transfusion products should be given remains to be established in a civilian trauma population. METHODS Data were obtained from a multicenter prospective cohort study evaluating clinical outcomes in blunt injured adults with hemorrhagic shock. Those patients who required >/=8 units PRBCs within the first 12 hours postinjury were analyzed (n = 415). RESULTS Patients who received transfusion products in >/=1:1.50 FFP:PRBC ratio (high F:P ratio, n = 102) versus <1:1.50 FFP:PRBC ratio (low F:P, n = 313) required significantly less blood transfusion at 24 hours (16 +/- 9 units vs. 22 +/- 17 units, p = 0.001). Crude mortality differences between the groups did not reach statistical significance (high F:P 28% vs. low F:P 35%, p = 0.202); however, there was a significant difference in early (24 hour) mortality (high F:P 3.9% vs. low F:P 12.8%, p = 0.012). Cox proportional hazard regression revealed that receiving a high F:P ratio was independently associated with 52% lower risk of mortality after adjusting for important confounders (HR 0.48, p = 0.002, 95% CI 0.3-0.8). A high F:P ratio was not associated with a higher risk of organ failure or nosocomial infection, however, was associated with almost a twofold higher risk of acute respiratory distress syndrome, after controlling for important confounders. CONCLUSIONS In patients requiring >/=8 units of blood after serious blunt injury, an FFP:PRBC transfusion ratio >/=1:1.5 was associated with a significant lower risk of mortality but a higher risk of acute respiratory distress syndrome. The mortality risk reduction was most relevant to mortality within the first 48 hours from the time of injury. These results suggest that the mortality risk associated with an FFP:PRBC ratio <1:1.5 may occur early, possibly secondary to ongoing coagulopathy and hemorrhage. This analysis provides further justification for the prospective trial investigation into the optimal FFP:PRBC ratio required in massive transfusion practice.
Transfer Function of Interfacial Stress Sensor for Artificial Skin Applications

To help improve the comfort of an amputee, it is important to develop artificial skin to understand the load distribution between the residual limb and the prosthetic socket for a prosthetic socket system. This paper presents an interfacial stress sensor which is capable of simultaneously measuring normal compressive stress and horizontal shear stress and is expected to create an artificial skin to understand such load distribution. A mathematical model based on regression analysis is built and an experiment is conducted to obtain the transfer function of the sensor. A significance test shows that the transfer function has a statistical significance at a significance level of 0.05 and the regression model fits the experimental data with a sample determination coefficient . The relative error is also analyzed in the end. The results show that the sensor is capable of measuring a range 0-320 kPa normal compressive stress with a relative error of 5% and a range of 0-70 kPa horizontal shear stress with a relative error of 14%.
Antigenic Variation of the Haemagglutinin Gene of the Influenza A (H1N1) pdm09 Virus Circulating in Shiraz, February-April 2013.

BACKGROUND A new pandemic influenza A (H1N1) emerged in April 2009, causing considerable morbidity and mortality. Since mutations in the haemagglutinin (HA) may influence the antigenicity and pathogenicity of the virus, continued epidemiological and molecular characterization for the effective control of pandemic flu and developing of more appropriate vaccine is crucial. OBJECTIVE To monitor the molecular evolution of A (H1N1) pdm09 viruses in a specific time period in Shiraz, Southern Iran. METHODS A total of 200 samples were collected from February-April 2013. HA gene of the isolates was amplified and sequenced. Phylogenetic analysis of the HA gene was performed. RESULTS Out of 200 samples, a total of 77 (38.5%) samples were confirmed as A (H1N1) pdm09 virus using Real-time PCR method. Nucleotide similarity of our study strains with respect to reference strain A/California/07/2009 (H1N1) was 97.5%-98.5%. Phylogenetic analysis of our study strains indicated that the dominant A (H1N1) pdm09 clade was clade 7 and the dominant genetic group in circulating strains in Shiraz was genetic group 6. Some of our study strains showed substitutions at or in the vicinity of the antigenic sites of the HA1 region which may affect the efficacy of the vaccine. CONCLUSION Our study strains showed a high homology to the vaccine strain. Our findings confirm the genetic variability of influenza A (H1N1) pdm09 and highlight the necessity of continuous molecular study of the virus for effective management of influenza.
Work‐life policy: does it do exactly what it says on the tin?

Policies which help employees balance their work and non‐work priorities have become increasingly popular among UK employers in recent years. Along with a legislative imperative for family leave‐related policies, employers are being encouraged to introduce work‐life policies and make them more inclusive in order to enhance their business performance. This paper looks at how four financial services organisations have approached the work‐life balance agenda and examines the fit between the organisational intentions for work‐life policy and actual outcomes for both organisations and employees. Culture played a large part in determining the experience of policies but so did resources. What managers were being asked to achieve in the business was often incompatible with formal work‐life policies. Despite the rhetoric, work‐life balance was still viewed as a tool for, and was used by female parents, limiting its potential to achieve the promoted business benefits.
WSDM 2017 Workshop on Mining Online Health Reports: MOHRS 2017

The workshop on Mining Online Health Reports (MOHRS) draws upon the rapidly developing field of Computational Health, focusing on textual content that has been generated through the various facets of Web activity. Online user-generated information mining, especially from social media platforms and search engines, has been in the forefront of many research efforts, especially in the fields of Information Retrieval and Natural Language Processing. The incorporation of such data and techniques in a number of health-oriented applications has provided strong evidence about the potential benefits, which include better population coverage, timeliness and the operational ability in places with less established health infrastructure. The workshop aims to create a platform where relevant state-of-the-art research is presented, but at the same time discussions among researchers with cross-disciplinary backgrounds can take place. It will focus on the characterisation of data sources, the essential methods for mining this textual information, as well as potential real-world applications and the arising ethical issues. MOHRS '17 will feature 3 keynote talks and 4 accepted paper presentations, together with a panel discussion session.
Deblurring random blur

We introduce a modified Backus-Gilbert technique for restoring an image that has been distorted by a linear system whose impulse response function is itself random, and in the presence of detection noise. The restoration is based on a weighted superposition of a small number of shifted versions of the distorted image. Optimum weights are determined to minimize a measure of the average width of the impulse response functions of the overall system and the noise variance.
Inflation, Growth, and Credit Services

The empirical evidence suggests that there is a significant, negative relationship between inflation and economic growth. Conventional monetary growth models, however, predict a significantly smaller growth effect. This paper proposes a monetary growth model with an explicit credit service sector to explain the observed magnitude. Since credit services are assumed costly to produce, the consumers equate the opportunity cost of holding money with the marginal cost of credit. Therefore the technology of the financial sector influences the velocity of money, and consequently, how inflation affects leisure, the time spent accumulating human capital, and the growth rate of output. The calibration shows that the model generates an inflation-growth effect whose magnitude falls in the range found by the empirical studies. Moreover, in contrast to previous works, we are also able to explain an inflation-growth effect that becomes increasingly weak as the inflation rate rises, as the evidence seems to suggest. Analysis of the welfare cost of inflation further illuminates the inflation-growth effect and how the model compares to the literature.
An Analytic Approach to Random Phase Error and Its Impact on the Performance and Design of Arrayed-Waveguide Gratings

Random phase error due to fabrication process causes the filter response of arrayed-waveguide grating (AWG) to degrade, especially in terms of crosstalk. In the side-lobe region, which is critical to the channel crosstalk performance, each instantiation of the random phase error can yield a significantly different filter transmission than that of the average for that level of phase error. In this report, the statistical behavior of the AWG filter transmission in the side-lobe region is studied analytically. Both the distribution of random side-lobe level at a given wavelength and an upper bound of the outage probability for side-lobe maxima are given in a simple closed form. Accordingly, a crosstalk margin needs to be allocated to ensure a given fabrication yield and this is shown to depend on the fractional bandwidth of the AWG filter. For filter shapes that are close to Gaussian, this crosstalk margin can be 8 dB or more above the average crosstalk level, for small fractional bandwidth of about 1% and fabrication yields of 80% or higher. These relations should be useful to AWG designers particularly when the underlying fabrication process is susceptible to nonnegligible random phase errors.
Seeking signatures of reinforcement at the genetic level: a hitchhiking mapping and candidate gene approach in the house mouse

Reinforcement is the process by which prezygotic isolation is strengthened as a response to selection against hybridization. Most empirical support for reinforcement comes from the observation of its possible phenotypic signature: an accentuated degree of prezygotic isolation in the hybrid zone as compared to allopatry. Here, we implemented a novel approach to this question by seeking for the signature of reinforcement at the genetic level. In the house mouse, selection against hybrids and enhanced olfactory‐based assortative mate preferences are observed in a hybrid zone between the two European subspecies Mus musculus musculus and M. m. domesticus, suggesting a possible recent reinforcement event. To test for the genetic signature of reinforcing selection and identify genes involved in sexual isolation, we adopted a hitchhiking mapping approach targeting genomic regions containing candidate genes for assortative mating in mice. We densely scanned these genomic regions in hybrid zone and allopatric samples using a large number of fast evolving microsatellite loci that allow the detection of recent selection events. We found a handful of loci showing the expected pattern of significant reduction in variability in populations close to the hybrid zone, showing assortative odour preference in mate choice experiments as compared to populations further away and displaying no such preference. These loci lie close to genes that we pinpoint as testable candidates for further investigation.
Explaining Differences in Prices Received by Farmers: Testing Theory Based on Actual Farmer Transactions

There has been considerable normative research about how farmers should make marketing decisions, but little positive research on what farmers really do. Regressions of gender, total volume, timing, and frequency of sales on the average weighted price received are used to test hypotheses regarding gender differences, myopic loss aversion, economies of size, and market efficiency.
Qualimetrics and qualieconomics

Notes that in many organizations, quality management fulfills a role which is not measured or even quantitively estimated. Notes that elements such as sales and productivity are principally dollar‐oriented and that the quality manager will feel an outsider if he/she is unable to communicate in such terms. Suggests that the quality economics principle has been used to overcome this communication gap. Looks at factors such as cost of quality and value of quality, net value‐added productivity and quality by objectives. Notes that the integration of cost of quality, added value productivity and quality by objectives complements the economic value of quality.
In between Curing and Counting: Performative Effects of Experiments With Healthcare Information Infrastructure

Performance standards and accountability pervade modern healthcare. According to Michael Power, this may signify a new rationality of governance characterized by control of controls, which affects practices not by direct intervention, but through the processes by which practices are made auditable. The paper addresses this thesis by exploring the construction of a Danish standard for electronic patient records. It is shown that making healthcare auditable activates deep tensions between programs of clinical practice, quality control, evidence based medicine, and casemix funding, resulting in an ambiguous and unstable standard. During this process, however, particular notions of patients, diseases, and diagnoses emerge as undisputed innovations, which may come to survive the subsequent career of the standard. The paper discusses the performative effects of these innovations and argues that information infrastructure has become an analytically important site for exploring the substantial effects of new rationalities of governance in healthcare.
Unsatisfiable Core Shrinking for Anytime Answer Set Optimization

Efficient algorithms for the computation of optimum stable models are based on unsatisfiable core analysis. However, these algorithms essentially run to completion, providing few or even no suboptimal stable models. This drawback can be circumvented by shrinking unsatisfiable cores. Interestingly, the resulting anytime algorithm can solve more instances than the original algorithm.
Society of Gynecologic Oncology recommendations for the prevention of ovarian cancer

Mortality from ovarian cancer may be dramatically reduced with the implementation of attainable prevention strategies. The new understanding of the cells of origin and the molecular etiology of ovarian cancer warrants a strong recommendation to the public and health care providers. This document discusses potential prevention strategies, which include 1) oral contraceptive use, 2) tubal sterilization, 3) risk‐reducing salpingo‐oophorectomy in women at high hereditary risk of breast and ovarian cancer, 4) genetic counseling and testing for women with ovarian cancer and other high‐risk families, and 5) salpingectomy after childbearing is complete (at the time of elective pelvic surgeries, at the time of hysterectomy, and as an alternative to tubal ligation). The Society of Gynecologic Oncology has determined that recent scientific breakthroughs warrant a new summary of the progress toward the prevention of ovarian cancer. This review is intended to emphasize the importance of the fallopian tubes as a potential source of high‐grade serous cancer in women with and without known genetic mutations in addition to the use of oral contraceptive pills to reduce the risk of ovarian cancer. Cancer 2015;121:2108–2120. © 2015 American Cancer Society.
The Ride to Modernity: The Bicycle in Canada, 1869–1900. By Glen Norcliffe. Toronto: University of Toronto Press, 2001. Photos, maps, illustrations. Cloth, $60.00; paper, $24.95. ISBN: Cloth 0-802-04398-4; paper 0-802-08205-X

Most books about cycling—including the history of the bicycle and cycling—are hobbyist books. This is not a hobbyist book; it is a serious academic study. The author, who is a professor of geography at York University in Toronto, "recognize[s] the danger of trying to write for two audiences, and pleasing neither. This essay is addressed to an academic audience, but [his] hope is that the contents will also be of interest to, and accessible to bicycle enthusiasts" (p. xv). While the hobbyist reader might not appreciate fully the context provided by sociologists, economists, and social historians called upon by Norcliffe, there is sufficient material here, including the profusion of illustrations that typify books on bicycles and cycling, to make this book of interest to readers with at least a passing interest in the social history of the bicycle (and not only in Canada). Two important theoretical constructs run through this book: modernity and carrier wave (of which more below). Modernity as a movement has its philosophical origins in the Enlightenment and has important social (behavioral) and political dimensions. There are also technical and economic dimensions. The bicycle and its history are situated throughout this book in considerations of modernity. The bicycle was not modern just because it was new; it was modern because it contributed to a modern image of the owner or rider and to technical innovation that, Norcliffe argues, underpinned the development of perhaps the most persistently "modern" artifact of all time: the motor car. "Carrier wave" is best explained in Norcliffe s own words:
Dynamic Regulation of Notch 1 and Notch 2 Surface Expression during T Cell Development and Activation Revealed by Novel Monoclonal Antibodies1

It is well established that Notch signaling plays a critical role at multiple stages of T cell development and activation. However, detailed analysis of the cellular and molecular events associated with Notch signaling in T cells is hampered by the lack of reagents that can unambiguously measure cell surface Notch receptor expression. Using novel rat mAbs directed against the extracellular domains of Notch1 and Notch2, we find that Notch1 is already highly expressed on common lymphoid precursors in the bone marrow and remains at high levels during intrathymic maturation of CD4−CD8− thymocytes. Notch1 is progressively down-regulated at the CD4+CD8+ and mature CD4+ or CD8+ thymic stages and is expressed at low levels on peripheral T cells. Immunofluorescence staining of thymus cryosections further revealed a localization of Notch1+CD25− cells adjacent to the thymus capsule. Notch1 was up-regulated on peripheral T cells following activation in vitro with anti-CD3 mAbs or infection in vivo with lymphocytic chorio-meningitis virus or Leishmania major. In contrast to Notch1, Notch2 was expressed at intermediate levels on common lymphoid precursors and CD117+ early intrathymic subsets, but disappeared completely at subsequent stages of T cell development. However, transient up-regulation of Notch2 was also observed on peripheral T cells following anti-CD3 stimulation. Collectively our novel mAbs reveal a dynamic regulation of Notch1 and Notch2 surface expression during T cell development and activation. Furthermore they provide an important resource for future analysis of Notch receptors in various tissues including the hematopoietic system.
A Note on Group Strategy-Proof Decision Schemes

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Where Have All the Towers Gone? the Dismantling of Public Housing in U.S. Cities

ABSTRACT: Public housing authorities (PHAs) across the country are demolishing and selling off public housing units. Although some of the units are being replaced in mixed-income developments, most are not; the subsidies instead are being shifted into household-based vouchers. Thus, in most cases the loss of these units is a permanent reduction in the nation’s public housing stock. Demolition efforts are more extensive in some cities than in others. This paper analyzes public housing removal in the largest cities of the United States to explain the pattern of demolitions taking place. The analysis reveals that public housing removal is most prevalent in cities facing gentrification pressures, and in cities in which the management of public housing by the local housing authorities was subpar. Public housing removals are also associated with higher levels of racial segregation and violent crime.
Cross-country inequalities in aggregate welfare: some evidence

International inequality in aggregate welfare levels has been estimated with the help of Sen and Theil indexes. Results reveal that welfare inequalities have reduced recently and that mean income differences explain most of these inequalities, and its reduction. These findings imply that, at least from the perspective of the Sen Index, no significant information is lost if per capita incomes inequalities are used as a proxy of welfare levels differences.
Examining the willingness of Americans to alter behaviour to mitigate climate change

Despite the increasing interest in climate change policy in the US, little systematic research has been conducted on the willingness of individuals to change their behaviour to mitigate the problem. Understanding behavioural change is critical if federal and local governments intend to implement programmes requiring actions to mitigate and adapt to climate change. This understudied aspect of climate change policy is addressed by quantitatively examining the degree to which residents living in the US are willing to alter their behaviour to mitigate climate change impacts, and by identifying the major factors contributing to this willingness. Based on a national survey, the reported willingness of individuals to alter behaviours is explained, using the components of risk, individual stress, capacity and ecological values. The findings indicate that specific personal traits and contextual characteristics trigger a significantly greater willingness to change longstanding behavioural patterns. These insights into the factors motivating behavioural change can provide guidance to decision makers at both federal and local levels on how best to implement climate change policies.
Destination network management: a conceptual analysis

Purpose – This paper aims to focus on managing networks within destinations, or destination network management. The purpose is to provide a conceptual definition of the term.Design/methodology/approach – Destinations are seen as networks, and networks are approached from a strategic perspective. Reviewing and drawing on the literature on destination management, tourism networks, strategic networks and strategic management the paper proposes a concept that could be of use in analyses of network management.Findings – It is suggested that managing is a value‐creating activity embedded within a network, and that there are two approaches to network management: strategic management and the coordination of cooperation among the actors involved.Research limitations/implications – The paper is conceptual in nature. The authors intend to test the developed hypothesis in empirical case studies in the near future.Originality/value – The paper contributes to the literature on destination management in proposing a nove.