Miracle-dz/UniFAR-FTUs huggingface dataset:
Synthesis of the major oil-body membrane protein in developing rapeseed (Brassica napus) embryos. Integration with storage-lipid and storage-protein synthesis and implications for the mechanism of oil-body formation.

The synthesis of the major protein and lipid storage reserves during embryogenesis in oilseed rape (Brassica napus L., cv. Mikado) has been examined by biochemical, immunological and immunocytochemical techniques. The mature seeds contained about 45% (w/w) storage oil and 25% (w/w) protein. There were three major seed protein components, i.e. about 40-50% total protein was cruciferin, 20% was napin and 20% was a 18 kDa hydrophobic polypeptide associated with the proteinaceous membrane surrounding the storage oil bodies. Embryogenesis was divided into four overlapping stages with regard to the synthesis of these storage components: (1) for the first 3 weeks after flowering, little, if any, synthesis of storage components was observed; (2) storage-oil synthesis began at about week 3, and maximal rates were from weeks 4 to 7; (3) synthesis of the soluble storage proteins cruciferin and napin started at week 6 and rates were maximal between weeks 8 and 11; (4) the final stage was the synthesis of the 19 kDa oil-body polypeptide, which started at weeks 8-10 and was at a maximal rate between weeks 10 and 12. The synthesis of the 19 kDa oil-body protein therefore occurred independently of the synthesis of the soluble seed storage proteins. This former synthesis did not occur until shortly before the insertion of the 19 kDa polypeptide into the oil-body membrane. No evidence was found, either from sucrose-density-gradient-centrifugation experiments or from immunogold-labelling studies, for its prior accumulation in the endoplasmic reticulum. Conventional and immunogold-electron-microscopic studies showed that oil bodies were synthesized in the early to middle stages of seed development without a strongly electron-dense membrane. Such a membrane was only found at later stages of seed development, concomitantly with the synthesis of the 19 kDa protein. It is proposed that, in rapeseed embryos, oil bodies are initially formed with no proteinaceous membrane. Such a membrane is formed later in development after insertion by ribosomes of the hydrophobic 19 kDa polypeptide directly into the oil bodies.
Practical High-Throughput Content-Based Routing Using Unicast State and Probabilistic Encodings

We address the problem that existing publish/subscribe messaging systems, including such commonly used ones as Apache’s ActiveMQ and IBM’s WebSphere MQ, exhibit degraded end-to-end throughput performance in a wide-area network setting. We contend that the cause of this problem is the lack of an appropriate routing protocol. Building on the idea of a content-based network, we introduce a protocol called B-DRP that can demonstrably improve the situation. A content-based network is a content-based publish/subscribe system architected as a datagram network: a message is forwarded hop-by-hop and delivered to any and all hosts that have expressed interest in the message content. This fits well with the character of a wide-area messaging system. B-DRP is based on two main techniques: a message delivery mechanism that utilizes and exploits unicast forwarding state, which can be easily maintained using standard protocols, and a probabilistic data structure to e ciently represent and evaluate receiver interests. We present the design of B-DRP and the results of an experimental evaluation that demonstrates its support for improved throughput in a wide-area setting.
Away-From-Home Foods Increasingly Important to Quality of American Diet

The increasing popularity of dining out over the past two decades has raised the proportion of nutrients obtained from away-from-home food sources. Between 1977 and 1995, home foods significantly improved their nutritional quality, more so than away-from-home foods, which typically contained more of the nutrients overconsumed (fat and saturated fat) and less of the nutrients underconsumed (calcium, fiber, and iron) by Americans. Since the trend of eating out frequently is expected to continue, strategies to improve the American diet must address consumers' food choices when eating out. This report analyzes food intake survey data collected by USDA over the past two decades to compare the nutritional quality of home and away-from-home foods and examine how the quality has changed over time.
Model-free formation tracking control of networked robotic systems with input disturbances

This paper studies the model-free formation tracking problem for networked robotic systems in the presence of bounded input disturbances. The interaction topology of the networked robotic system is assumed to contain a spanning tree. Based on distributed sliding-mode estimators aiming to estimate the information of the reference trajectory, we propose the model-free control law which can obtain the formation of the networked robotic system in the local coordinate system, and meanwhile the tracking of the geometric centre of the formation. The asymptotic stability and its sufficient condition on the control parameters are derived via the Lyapunov theory. Finally, the simulation results are provided to verify the effectiveness of the main results.
Assisted editing in the biomedical domain: motivation and challenges.

One of the characteristics of biomedical scientific literature is the high ambiguity of the domain-specific terminology which can be used to describe technical concepts and specific objects of the domain. This is partly due to the very broad scope of the domain of interest and partly to inherent properties of the terminology itself. There aresimply very large numbers of genes, proteins, organs, cell lines, cellular phenomena, experimental methods, and so on. For example, UniProt, the most authoritative protein database, currently contains more than 33 million entries. Clearly, the names which are typically used to refer to proteins are polysemic and might refer to hundreds of different entries in a reference database. Such a large and extensive terminology necessarily makes it difficult to derive from the literature a simplified representation of the entities and relationships described in the articles, despite considerable efforts by the text mining community. In this paper we propose to complement such efforts with editing tools that can assist the authors in efficiently adding to their publications a minimal semantic annotation so that much of the ambiguity is avoided.
Clinical implications of a recent adjustment to the high-sensitivity cardiac troponin T assay: user beware.

To the Editor: Roche Diagnostics recently issued a technical bulletin calling for an adjustment to the calibration curve for the Elecsys Troponin T hs and Elecsys Troponin T hs STAT assays. Although this bulletin was disseminated widely in some countries, it was less widely distributed in others. The Roche high-sensitivity (hs) assays are in clinical use worldwide except within the US, where they are used for research but have not yet been cleared by the Food and Drug Administration. Roche has characterized this action as a “minor adjustment” to the low-end standardization of the Troponin T hs assays in order to return to the original assay specifications. The new revised lots (numbers 167345 and 167650) yield measurable cardiac troponin T concentrations in hs assays in a greater proportion of patient samples for which the concentrations were undetectable with previous lots [163704 (Troponin T hs) and 164773 (Troponin T hs STAT)] and older lots (6 lots total). Specifically, Roche has indicated that the new lots will produce higher recoveries at low concentrations (3–20 ng/L) and produce a shift upward—as much …
The CMS PhEDEx System : a Novel Approach to Robust Grid Data Distribution

The CMS experiment has taken a novel approach to Grid data distribution. Instead of having a central processing component making global decisions on replica allocation, CMS has a data management layer composed of a series of collaborating agents; the agents are persistent, stateless processes which manage specific parts of replication operations at each site in the distribution network. The agents communicate asynchronously through a blackboard architecture; as a result the system is robust in the face of many local failures. CMS’ data distribution network is represented in a similar fashion to the internet. This means that the management of multi-hop transfers at dataset level is simple. This system allows CMS to seamlessly bridge the gap between traditional HEP “waterfall” type data distribution, and more dynamic Grid data distribution. Using this system CMS is able to reach transfer rates of 500Mbps, and sustain transfers for long periods in tape-to-tape transfers. The system has been used to manage branches of large scale Service Challenges for LCG this year.
Finite Element Based Solder Joint Fatigue Life Predictions for a Same Die Stacked Chip Scale Ball Grid Array Package

Viscoplastic finite-element simulation methodologies were utilized to predict solder joint reliability for a same die size, stacked, chip scale, ball grid array package under accelerated temperature cycling conditions (-40C to +125C, 15min ramps/15min dwells). The effects of multiple die attach material configurations were investigated along with the thickness of the mold cap and spacer die. The solder structures accommodate the bulk of the plastic strain that is generated during accelerated temperature cycling due to the thermal expansion mismatch between the various materials that encompass the stacked die package. Since plastic strain is a dominant parameter that influences low-cycle fatigue, it was used as a basis for evaluation of solder joint structural integrity. The paper discusses the analysis methodologies as implemented in the ANSYS finite element simulation software tool and the corresponding results for the solder joint fatigue life. Some ANSYS parametric design language commands are included for the benefit of those readers who are familiar with the tool.
Sex differences in μ‐opioid receptor expression in trigeminal ganglia under a myositis condition in rats

Peripheral opioid receptor expression is up‐regulated under inflammatory conditions, which leads to the increased efficacy of peripherally administered opioids. Sex differences in the effects of inflammation, cytokines and gonadal hormones on μ‐opioid receptor (MOR) expression in trigeminal ganglia (TG) are not well understood.
Activation of K(ATP) channels suppresses glucose production in humans.

Increased endogenous glucose production (EGP) is a hallmark of type 2 diabetes mellitus. While there is evidence for central regulation of EGP by activation of hypothalamic ATP-sensitive potassium (K(ATP)) channels in rodents, whether these central pathways contribute to regulation of EGP in humans remains to be determined. Here we present evidence for central nervous system regulation of EGP in humans that is consistent with complementary rodent studies. Oral administration of the K(ATP) channel activator diazoxide under fixed hormonal conditions substantially decreased EGP in nondiabetic humans and Sprague Dawley rats. In rats, comparable doses of oral diazoxide attained appreciable concentrations in the cerebrospinal fluid, and the effects of oral diazoxide were abolished by i.c. v. administration of the K(ATP) channel blocker glibenclamide. These results suggest that activation of hypothalamic K(ATP) channels may be an important regulator of EGP in humans and that this pathway could be a target for treatment of hyperglycemia in type 2 diabetes mellitus.
Effect of Personality Factors on Performance in Rehabilitation Assessment and Vocational Reintegrationprognosis

INTRODUCTION A necessary prerequisite for a successful vocational rehabilition and reintegration process is adequate knowledge of relevant factors of the participants (Köster, Fehr & Slesina, 2007). With regard to cognitive factors, concensus exists that intelligence validly predicts vocational success. Personality factors appear to have an incremental contribution to vocational success (e.g. Schmidt & Hunter, 1998). With respect to vocational rehabilitation there is also evidence that personality factors infl uence this process (e.g. Schroeder & Steinwede, 2004). The objective of this study was to further examine to what extent cognitive and personality factors contribute to performance during the initial phase of assessing vocational fi tness and to the prognosis of vocational reintegration.
Automatic Single-Document Key Fact Extraction from Newswire Articles

A novel recombinant DNA containing the base sequence shown in FIG. 1 or a portion thereof which exhibits promoter activity. The base sequence exhibiting a potent promoter activity is obtained from the chromosomal DNA of strain Bacillus by, for example, cloning with a cloning vector. By growing a transformant of Bacillus transformed with the recombinant DNA carrying a peptide encoding nucleotide, the desired peptide may be produced.
On the interpretation of the cosmic-ray anisotropy at ultra-high energies

A natural interpretation of the correlation between nearby Active Galactic Nuclei (AGN) and the highest-energy cosmic rays observed recently by the Pierre Auger Collaboration is that the sources of the cosmic rays are either AGN or other objects with a similar spatial distribution (the ``AGN hypothesis''). We question this interpretation. We calculate the expected distribution of the arrival directions of cosmic rays under the AGN hypothesis and argue that it is not supported by the data, one of manifestations of the discrepancy being the deficit of events from the direction of the Virgo supercluster. We briefly discuss possible alternative explanations including the origin of a significant part of the observed events from Cen A.
HNVM : Hybrid NVM Enabled Datacenter Design and Optimization Yanqi

Emerging non-volatile memories (NVMs) like batterybacked DRAM and phase-change memory offer durability at higher speeds than traditional storage. Each technology represents a different point in the cost, performance and endurance space. In this paper, we propose that storage intensive applications use more than one kind of NVM in configurable proportions to strike a balance between cost, performance and
Cocontraction and phasic activity during GAIT in children with cerebral palsy.

Simultaneous activity of agonist and antagonistic muscles during a task is known as cocontraction. The primary aim of the present study was to use a cocontraction index (CI) to quantify differences in EMG activity between a group of CP and control children at two different walking speeds. The secondary aim was to compare the amount of time the muscles were activated ("on" thresholds) between the groups. Seventeen subjects volunteered for the study. One group consisted of 9 (7M, 2F) children with CP (age 12.7 +/- 2.8 years, mean +/- SD). The second group consisted of 8 able-bodied controls (7M, 1F). The discontinuous submaximal treadmill walking protocol had two 4min stages at 0% gradient. Speeds selected were 3 km.h-1 and 90% of the pre-determined fastest walking speed (FWS). Two sites of CI were measured from the EMGs of tibialis anterior and soleus (leg) and vastus lateralis and hamstrings (thigh). Significantly (p < 0.05) higher CI values were noted for the CP subjects compared to the controls, irrespective of speed or cocontraction site and there was a significant (p < 0.05) increase in CI values with increased walking speed for both CP and control subjects. Phasic analyses for 5% max EMG and 10% max EMG "on" thresholds demonstrated significant (p < 0.05) main effects for group (CP subjects had a longer time period of muscle activation than controls) and speed (muscles were active longer at 90% FWS than 3 km.h-1). The precise mechanisms by which cocontraction contributes toward abnormal gait and wasted mechanical energy require further research incorporating both electromyographic and kinematic analysis.
Pronunciation Variants Across Systems, Languages and Speaking Style

This contribution aims at evaluating the use of pronunciation variants across different system configurations, languages and speaking styles. This study is limited to the use of variants during speech alignment, given an orthographic transcription and a phonemically represented lexicon, thus focusing on the modeling abilities of the acoustic word models. Parallel and sequential variants are tested in order to measure the spectral and temporal modeling accuracy. As a preliminary step we investigated the dependance of the aligned variants on the recognizer configuration. A crosslingual study was carried out for read speech in French and American English using the BREF and the WSJ corpora. A comparison between read and spontaneousspeech is presented for French based on alignments from BREF (read) and MASK (spontaneous) data.
Acute psychosis following ingestion of 'Rapture'.

OBJECTIVES To describe a brief psychotic episode associated with ingestion of a dietary supplement containing piperazine. METHODS A case report was undertaken. RESULTS A 20-year-old man developed a brief psychotic episode associated with persecutory delusional beliefs and auditory and visual hallucinations, leading him to commit the offence of arson. This episode occurred 12 h following the ingestion of 'Rapture' in addition to small quantities of cannabis and nitrous oxide, in a young man with no prior psychiatric history. This episode resolved with the use of benzodiazepines and 6 months later he has had no recurrence of psychiatric symptoms. CONCLUSIONS Given the reported mechanism of action of the 'herbal high' dietary supplements, it would seem possible that they may be able to precipitate a psychotic episode in vulnerable individuals. With the increasing use of these substances, it is important for clinicians to be alert to this possibility.
EMOSEDE : Emotion and Sentiment Detection HUSO 2016 , The Second International Conference on Human and Social Analytics ( IARIA conference )

In the past decade, we have witnessed the rise of the Web 2.0 technologies, which allow the general public to add text to message boards, blogs, reviewing sites or social networking sites such as Twitter or Facebook. At the same time, research in the field of sentiment analysis has thrived, especially on social media data. Knowing what other people think has always played a major role in our decision making process. This holds for individuals looking for opinions about specific products or services, but to a larger extent even for companies and organizations who want to know the sentiments of the general public towards their products, brands, policies, political viewpoints, etcetera. In addition to sentiment analysis, which classifies text as positive or negative, researchers have started to automatically identify more fine-grained emotions in text, resulting in the related field of affect analysis or emotion detection. In crisis situations, for instance, companies are not only interested in detecting negative or positive messages, they also want to know whether people are angry, supportive, sad or disgusted in order to fine-tune their crisis communication strategy. This special session will focus on topics related to sentiment and emotion analysis, stylometry and the influence of emotional states on natural language generation. Keywords-sentiment analysis, emotion detection, personality detection, affective language, natural language processing
HPC I/O trace extrapolation

Today's rapid development of supercomputers has caused I/O performance to become a major performance bottleneck for many scientific applications. Trace analysis tools have thus become vital for diagnosing root causes of I/O problems. This work contributes an I/O tracing framework with elastic traces. After gathering a set of smaller traces, we extrapolate the application trace to a large numbers of nodes. The traces can in principle be extrapolated even beyond the scale of present-day systems. Experiments with I/O benchmarks on up to 320 processors indicate that extrapolated I/O trace replays closely resemble the I/O behavior of equivalent applications.
Domain Decomposition Methods for Monotone Nonlinear Elliptic Problems

In this paper we study several overlapping domain decompo sition based iterative algorithms for the numerical solution of some non linear strongly elliptic equations discretized by the nite element methods In particular we consider additive Schwarz algorithms used together with the classical inexact Newton methods We show that the algorithms con verge and the convergence rates are independent of the nite element mesh parameter as well as the number of subdomains used in the domain de composition Introduction Schwarz type overlapping domain decomposition methods have been studied extensively in the past few years for linear elliptic nite element problems see e g In this paper we extend some of the theory and methods to the class of nonlinear strongly elliptic nite element problems The rst study of the classical Schwarz alternating method for nonlinear elliptic equations appeared in the paper of P L Lions in which the class of continuous monotonic elliptic problems was investigated There are basically two approaches that a domain decomposition method can be used to solve a nonlinear problem The rst approach is to locally linearize the nonlinear equation via a Newton like algorithm and then to solve the resulting linearized problems at each nonlinear iteration by a domain decomposition method The second approach is to use domain decomposition such as the Schwarz alternating method directly on the Mathematics Subject Classi cation F N N
Microscopy methods for morpho-functional characterisation of marine invertebrate haemocytes

In this chapter, a useful list of well#established morphological and functional protocols is provided, to facilitate the design of experiments in the field of the characterisation of haemocytes of marine invertebrates, which have been emerging in the last decade as model organisms in ecotoxicology, comparative immunology, phylogenesis and evolution. This treatment offers a brief collection of methods and procedures for both light and electron microscopy, most of which were previously developed for vertebrates and therefore require modifications and adjustments. Many suggestions to solve common difficulties and errors are presented and clearly explained, covering haemocyte collection, cell culture, techniques of staining, and enzyme histochemistry and immunohistochemistry to obtain the best results.
The Natural History of Doryphora sp. (Coleoptera, Chrysomelidae) and the Function of its Sternal Horn

The beetle Doryphora sp. near punctatissima uses its sternal horn as a weapon in intraspecific aggressive encounters on the food plant Prestonia isthmica Woodson where eggs are laid and larvae and adults feed. Eggs are laid in groups and hatch in about a week. Larvae complete development in groups, and sometimes consume all leaves on a host plant. Larvae burrow into the soil to pupate; adults emerge in about 24 days. Adults display little apparent courtship behavior; mating can last longer than 1 hour and females apparently mate more than once. Aggressive behavior of adults is most likely related to defense of the food plant.