Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of Analgesic Efficacy of Dexmedetomidine and Midazolam as Adjuncts to Lignocaine for Intravenous Regional Anesthesia

Background: Intravenous regional anesthesia (IVRA) is safe, technically simple, and cost-effective technique compared to general anesthesia with success rates of 94–98% for upper and lower limb surgeries. The main disadvantage of this procedure is its limited duration for surgery, lack of postoperative analgesia, and tourniquet pain. To overcome this disadvantage, various adjuvants to lignocaine have been studied from time to time. Aim: To compare the analgesic efficacy of dexmedetomidine and midazolam as adjuncts to lignocaine for IVRA for forearm and hand surgeries. Setting and Design: The study was conducted by the Department of Anaesthesia of Medical College and patients posted for elective as well as the emergency forearm and hand surgeries were included in the study. It was a prospective comparative study. Materials and Methods: Sixty patients of either sex belonging to the American Society of Anesthesiologists Class I and II, in the age range of 18–65 years, scheduled for upper limb orthopedic surgery, either elective or emergency, were included in the study. All patients were administered IVRA in this prospective, double-blind, randomized study. Patients enrolled in the study were randomly divided into two groups of thirty each. Group M-received 40 ml of 0.5% lignocaine with midazolam 50 μg/kg and Group D-received 40 ml of 0.5% lignocaine with dexmedetomidine 1 μg/kg. Time of onset of sensory block, duration of analgesia, total dose of fentanyl given, intraoperative blood pressure, oxygen saturation, heart rate, postoperative analgesia, and adverse effects were recorded and compared between the groups. Statistical Analysis Used: The statistical evaluation was performed using SPSS version 17.0 software. All values were calculated with a 95% confidence interval. The parameters were expressed as mean ± standard deviation and t-test was used for comparing demographic and clinical data. For comparisons,P< 0.05 was considered statistically significant. Results: Mean duration of analgesia was 93 ± 28 min in dexmedetomidine group and 84 ± 28 min in midazolam group, and onset of sensory block was comparable in both groups. Conclusion: Dexmedetomidine and midazolam, when used as adjuvants to lignocaine for IVRA, significantly improve the intraoperative conditions by providing superior quality of block. The superiority of one over the other could not be established as midazolam produced the early onset of block and less requirement of fentanyl, whereas dexmedetomidine when added to IVRA provided longer duration of analgesia (93 ± 28 min) in comparison to midazolam (84 ± 28 min).
Network modeling issues for grid application scheduling

The dominant trend in scientific computing today is the establishment of platforms that span multiple institutions to support applications at unprecedented scales. On most distributed computing platforms a requirement to achieve high performance is the careful scheduling of distributed application components onto the available resources. While scheduling has been an active area of research for many decades most of the platform models traditionally used in scheduling research, and in particular network models, break down for platforms spanning wide-area networks. In this paper we examine network modeling issues for large-scale platforms from the perspective of scheduling. The main challenge we address is the development of models that are sophisticated enough to be more realistic than those traditionally used in the field, but simple enough that they are still amenable to analysis. In particular, we discuss issues of bandwidth sharing and topology modeling. Also, while these models can be used to define and reason about realistic scheduling problems, we show that they also provide a good basis for fast simulation, which is the typical method to evaluate scheduling algorithms, as demonstrated in our implementation of the SIMGRID simulation framework.
The social implications of embarrassment displays and restitution behavior

The present study examines the evaluative consequences of two kinds of reaction to committing a social transgression. In an experimental study, embarrassment display and restitution behaviour were manipulated orthogonally in the context of a videotaped incident in which an actor was seen to upset a sales display in a store. Subjects were shown one of the four versions of this incident and asked to rate the actor responsible for the mishap. It was reasoned that both appearing embarrassed and engaging in restitution would have positive, but distinct, effects on social evaluation, and that the beneficial effect of restitution would be mitigated by embarrassment display. Results were consistent with these expectations. Discussion focuses on the implications of these findings for the social function of embarrassment displays.
Análisis de la percepción social de los riesgos naturales: estudio comparado en municipios de España y Brasil

El riesgo es un concepto complejo y entender mejor su percepción social en su análisis puede contribuir con medidas mitigadoras de sus efectos (Olcina-Cantos 2006). La perspectiva social del riesgo es una importante herramienta en su gestión (Weingart 2007). La percepción del riesgo es útil para los servicios de protección civil y otras entidades de seguridad en los procesos de toma de decisiones y acciones (Coelho 2005). Conocer la percepción social la percepción social del riesgo torna más eficaz la gestión del riesgo (García-Tornel 1997).
Circadian Regulation of Diverse Gene Products Revealed by mRNA Expression Profiling of Synchronized Fibroblasts* 210

Genes under a 24-h regulation period may represent drug targets relevant to diseases involving circadian dysfunctions. As a testing model of the circadian clock system, we have used synchronized rat fibroblasts that are known to express at least six genes in a circadian fashion. We have determined the expression patterns of 9957 transcripts every 4 h over a total period of 76 h using high density oligonucleotide microarrays. The spectral analysis of our mRNA profiling data indicated that ∼2% (85 genes) of all expressed genes followed a robust circadian pattern. We have confirmed the circadian expression of previously known clock or clock-driven genes, and we identified 81 novel circadian genes. The majority of the circadian-regulated gene products are known and are involved in diverse cellular functions. We have classified these circadian genes in seven clusters according to their phase of cycling. Our pathway analysis of the mRNA profiling data strongly suggests a direct link between circadian rhythm and cell cycle.
The Strength of Direct Selection against Female Promiscuity Is Associated with Rates of Extrapair Fertilizations in Socially Monogamous Songbirds

A costs‐benefits approach has frequently been used to understand the evolutionary origin and maintenance of promiscuity in animal populations. Recent meta‐analyses suggest that direct costs to unfaithful females outweigh indirect benefits from infidelity in socially monogamous songbirds, suggesting that in this taxa, extrapair fertilization (EPF) evolved primarily as a self‐interest male tactic. Here we present results of comparative analysis to show that standardized selection gradients acting against female infidelity (direct costs of promiscuity) explain variation in EPF rates at an interspecific level in passerines. This result confirms that costs to females resulting from reduced parental care from cheated males constrain promiscuity in this group. Our data indicate that females exert resistance over EPFs when the costs of infidelity are high and, conversely, that the rate of EPFs increases when selection on females to defend themselves against EPF attempts by males is weak and costs of infidelity are low.
Three distinct neuroprotective functions of myricetin against glutamate‐induced neuronal cell death: Involvement of direct inhibition of caspase‐3

The excitatory neurotransmitter glutamate can accumulate in the brain and is thought to be involved in the etiology of many neurodegenerative disorders, including ischemia and Alzheimer disease. Therefore, it is important to search for compounds that reduce glutamate neurotoxicity. This glutamate‐mediated excitotoxicity is caused by intracellular Ca2+ overload via the N‐methyl‐D‐aspartate receptor NMDAR), reactive oxygen species (ROS) generation, and caspase‐3 activation. Here we show that the natural flavonoid myricetin inhibited glutamate‐induced excitotoxicity and protected neurons by multiple, distinct pathways. First, myricetin affected modulation of the NMDAR by phosphorylation, causing a subsequent reduction in glutamate‐induced intracellular Ca2+ overload. Second, myricetin inhibited the ROS production caused by glutamate. Finally, glutamate‐induced activation of caspase‐3 was reduced by myricetin treatment. Moreover, myricetin directly interacted with the active site of caspase‐3 via three hydrogen bonds and inhibited its activity. We conclude that myricetin inhibited glutamate‐induced neuronal toxicity by multiple biochemical pathways. These results show that myricetin is a potent antineurodegenerative compound and may contribute to the discovery of a drug with which to combat neurodegeneration. © 2008 Wiley‐Liss, Inc.
Information, Community, and Action: How Nonprofit Organizations Use Social Media

The rapid diffusion of “microblogging” services such as Twitter is ushering in a new era of possibilities for organizations to communicate with and engage their core stakeholders and the general public. To enhance understanding of the communicative functions microblogging serves for organizations, this study examines the Twitter utilization practices of the 100 largest nonprofit organizations in the United States. The analysis reveals there are three key functions of microblogging updates—“information,”“community,” and “action. ” Though the informational use of microblogging is extensive, nonprofit organizations are better at using Twitter to strategically engage their stakeholders via dialogic and community-building practices than they have been with traditional websites. The adoption of social media appears to have engendered new paradigms of public engagement. © 2012 Wiley Periodicals, Inc. (Authors are listed in alphabetical order. The authors would like to thank Tom Feeley, Richard Waters, Seungahn Nah, I-hsuan Chiu, Yuchao Huang, and Kenton Anderson for helpful comments and suggestions.)
BittenPotato: Tweet Sentiment Analysis by Combining Multiple Classifiers

In this paper, we use a bag-of-words of n-grams to capture a dictionary containing the most used ”words” which we will use as features. We then proceed to classify using four different classifiers and combine their results by apply a voting, a weighted voting and a classifier to obtain the real polarity of a phrase.
Isolation of Murine Natural Killer Cells

This unit describes the isolation of natural killer (NK) cells from mouse spleen. The basic protocol describes a method for preparing a highly purified NK cell population from mouse spleen by cytotoxic depletion of contaminating cells with selected monoclonal antibodies (MAbs), complement lysis, and density‐gradient centrifugation to eliminate dead cells. The advantage of this negative selection process is that the NK cells are not coated with antibody and, therefore, are not at risk of activation by antibody cross‐linking. Purity can then be assessed by cell surface phenotype.
Informal and Formal Social Support and Caregiver Burden: The AGES Caregiver Survey

Background We examined the associations of informal (eg, family members and friends) and formal (eg, physician and visiting nurses) social support with caregiver’s burden in long-term care and the relationship between the number of available sources of social support and caregiver burden. Methods We conducted a mail-in survey in 2003 and used data of 2998 main caregivers of frail older adults in Aichi, Japan. We used a validated scale to assess caregiver burden. Results Multiple linear regression demonstrated that, after controlling for caregivers’ sociodemographic and other characteristics, informal social support was significantly associated with lower caregiver burden (β = −1.59, P < 0.0001), while formal support was not (β = −0.30, P = 0.39). Evaluating the associations by specific sources of social support, informal social supports from the caregiver’s family living together (β = −0.71, P < 0.0001) and from relatives (β = −0.61, P = 0.001) were associated with lower caregiver burden, whereas formal social support was associated with lower caregiver burden only if it was from family physicians (β = −0.56, P = 0.001). Compared to caregivers without informal support, those who had one support (β = −1.62, P < 0.0001) and two or more supports (β = −1.55, P < 0.0001) had significantly lower burden. This association was not observed for formal support. Conclusions Social support from intimate social relationships may positively affect caregivers’ psychological wellbeing independent of the receipt of formal social support, resulting in less burden.
CoSA-Ottawa's volunteers' subjective experiences with 'sex offenders:' Taming the monstrous

People convicted of sexual offences are arguably one of the most marginalized criminal offender groups because both the general population and offender populations tend to have hardened views of these individuals (Spencer, 2009; Wilson & Prinzo, 2001). Circles of Support and Accountability Ottawa (CoSA-Ottawa) is an organization that helps people convicted of sexual offences reintegrate into society by challenging traditional forms of community reintegration. CoSA-Ottawa was founded on the principles of restorative justice, which are exemplified in their mottos “no more victims” and “no one is disposable. ” The organization relies on the commitment and contribution of volunteers to assist with the reintegration process. While there have been various studies on CoSA from different perspectives (Duwe, 2012; Fox, 2014; Wilson, Picheca, and Prinzo, 2007; Wilson & Prinzo, 2001), there have been few studies directly focusing on CoSA-Ottawa volunteers through a critical lens. This study examines the subjective experiences of CoSA-Ottawa volunteers who work with people labeled as ‘sex offenders. ’ The research was conducted using semistructured interviews with six participants. Each interview transcript was transcribed and analyzed using interpretative phenomenological analysis. The master themes that developed through this study include: the humanization of the monstrous, the reintegration and re-socialization through a helping relationship, and overall impacts of these relationships on CoSA-Ottawa volunteers. Using a governmentality and power conceptual framework, this thesis demonstrates how the relationships between the core members and volunteers are transformative and act as an extension of the carceral
Cloning and Sequencing of a Unique Antigen MPT70 from Mycobacterium tuberculosis H37Rv and Expression in BCG Using E. coli‐Mycobacteria Shuttle Vector

MPB70 is known to be an immunogenic mycobacterial protein secreted in large amounts from Mycobacterium bovis BCG (BCG) Tokyo. The analogous gene for MPT70 was cloned from Mycobacterium tuberculosis H37Rv which produces this protein in only a small amount. The gene encoding 193 amino acid residues inciuding 30 amino acids for the signal peptide. the promoter‐like sequence, and the ribosome‐binding site, was completely identical to that of BCG Tokyo. Computer analysis revealed that the carboxy‐terminal half of MPT70 was homologous to amino acid sequences of fasciclin 1, osteoblast‐specific factor 2 (OSF‐2), and human transforming growth factor‐beta induced gene product (βIG‐H3). Escherichia coli (E. coli) ‐mycobacteria shuttle vectors containing mpt70 or mpb70 genes 0.7kbp upstream of the 5′ end of them were able to be expressed in BCG Pasteur which is a MPB70 low‐producer, but the extent of the expression was not that of a high‐producer.
Physiological Ecology in the 21st Century: Advancements in Biologging Science1

Abstract Top pelagic predators such as tunas, sharks, marine turtles and mammals have historically been difficult to study due to their large body size and vast range over the oceanic habitat. In recent years the development of small microprocessor-based data storage tags that are surgically implanted or satellite-linked provide marine researchers a novel avenue for examining the movements, physiology and behaviors of pelagic animals in the wild. When biological and physical data obtained from the tags are combined with satellite derived sea surface temperature and ocean color data, the relationships between the movements, behaviors and physical ocean environment can be examined. Tag-bearing marine animals can function as autonomous ocean profilers providing oceanographic data wherever their long migrations take them. The biologging science is providing ecological physiologists with new insights into the seasonal movements, habitat utilization, breeding behaviors and population structures in of marine vertebrates. In addition, the data are revealing migration corridors, hot spots and physical oceanographic patterns that are key to understanding how organisms such as bluefin tunas use the open ocean environment. In the 21st century as ecosystem degradation and global warming continue to threaten the existence of species on Earth, the field of physiological ecology will play a more pivotal role in conservation biology.
The immunological basis of endotoxin-induced tumor regression. Requirement for T-cell-mediated immunity

It was shown that although intravenous administration of bacterial endotoxin caused extensive hemorrhagic necrosis of four different syngeneic murine tumors, only two of these tumors subsequently underwent complete regression: the two that were shown to be immunogeneic as classically defined. An immunologic basis for endotoxin- induced regression was further indicated by the additional findings that regression, but not hemorrhagic necrosis, of the two immunogenic tumors failed to occur in mice that were immunodepressed by whole-body gamma-irradiation, or that were made T-cell deficient by thymectomy and irradiation. That endotoxin-induced regression is T-cell mediated was suggested by the findings that tumor regression was followed by a state of long-lived immunity to a tumor cell challenge implant, and with the possession by the host of T cells that were capable of passively transferring this state of immunity to normal recipients. It is concluded that although parenteral injection of endotoxin causes hemorrhagic necrosis of most solid murine tumors, it is only those tumors that are immunogenic enough to evoke the generation of T-cell- mediated immunity which subsequently go on to completely regress.
Using NLP tools in the specification phase

The software quality control is one of the main topics in the Software Engineering area. To put the effort in the quality control during the specification phase leads us to detect possible mistakes in an early steps and, easily, to correct them before the design and implementation steps start. In this framework the goal of SAREL system, a knowledge-based system, is twofold. On one hand, to help software engineers in the creation of quality Software Requirements Specifications. On the other hand, to analyze the correspondence between two different conceptual representations associated with two different Software Requirements Specification documents. For the first goal, a set of NLP and Knowledge management tools is applied to obtain a conceptual representation that can be validated and managed by the software engineer. For the second goal we have established some correspondence measures in order to get a comparison between two conceptual representations. This information will be useful during the interaction.
STI571 enhances the therapeutic index of epothilone B by a tumor-selective increase of drug uptake.

PURPOSE The purpose is to investigate whether STI571, through platelet-derived growth factor receptor inhibition, enhances the therapeutic response to the chemotherapeutic drug epothilone B (EPO906) and, if so, to analyze the mechanism(s) underlying the effect. EXPERIMENTAL DESIGN SCID mice with s.c. human anaplastic thyroid carcinomas were treated with different doses of EPO906 alone or in combination with STI571 and with different timing of STI571 and EPO906 administration. Tumor growth, tumor interstitial fluid pressure (IFP), and uptake of EPO906 in tumors and normal organs were monitored. RESULTS STI571 potentiated the therapeutic effect of EPO906. Tumors subjected to combination treatment were >40% smaller than those subjected to monotreatment with EPO906. The improved efficacy was matched by reduced tumor IFP and a 3-fold increase in the tumor levels of EPO906. No significant increase of EPO906 levels was seen in liver, kidney, or the intestinal tract. Cotreatment did not reduce the tolerability of EPO906, as determined by measuring body weight throughout treatment. STI571-induced reduction in tumor IFP and increase in tumor uptake required a minimum of three daily doses of STI571 and was not observed 3 days after last treatment with STI571. The enhancement of EPO906 therapeutic efficacy was only observed when STI571 was scheduled in a manner associated with reduced tumor IFP and increased tumor uptake of EPO906. CONCLUSIONS We conclude that STI571 increases the therapeutic index of EPO906 by selectively increasing the EPO906 uptake in tumors. The correlations between STI571 effects on tumor IFP and tumor drug uptake of EPO906 suggest a causal relationship between these phenomena. The study thus validates STI571 for combination treatment to enhance the therapeutic index of EPO906 in particular and, possibly, of chemotherapeutics in general.
A higher-order extension for imperative synchronous languages

This article presents the very first effective design of higher-order modules in the synchronous programming language Esterel. Higher-order modules, together with the robust separate compilation scheme that implements it, allow us to address a yet unexplored application spectrum ranging from rapid prototyping of embedded functionality to hot reconfiguration of embedded software within the formal modeling framework of the "synchronous hypothesis". While extensions of data-flow synchronous languages had already been proposed for Lustre [11] and Signal [25], the adaptation of similar programming concepts to imperative synchronous frameworks like Esterel has long posed major technical challenges, due to the specificity of its model of computation. We present a framework including a formal semantics, a type system, and a modular code generator, that tackle this challenge. We consider a specific stack-based module call convention and a simple event pooling protocol; in consequence signals can refer to modules and modules can be transmitted and instantiated by referencing a signal. We define a type system that computes the potential emissions of a module and prove it sound. Our type system seamlessly fits an extension of Esterel's constructive semantics with higher-order modules.