Miracle-dz/UniFAR-FTUs huggingface dataset:
Inhibition of p65 Nuclear Translocation by Baicalein

We demonstrate that baicalein, a bioactive flavonoid originally isolated from Scutellaria baicalensis , inhibits LPS-induced expression of iNOS gene in RAW 264.7 cells. Treatment of peritoneal macrophages and RAW 264.7 cells with baicalein inhibited LPS-stimulated nitric oxide production in a dose-related manner. Immunohistochemical staining of iNOS and RT-PCR analysis showed that the decrease of NO was due to the inhibition of iNOS gene expression in RAW 264.7 cells. Immunostaining of p65, EMSA, and reporter gene assay showed that baicalein inhibited NF-κB nuclear translocation, DNA binding, and transcriptional activation, respectively. Collectively, these series of experiments indicate that baicalein inhibits iNOS gene expression by blocking NF-κB nuclear translocation. Due to the critical role that NO release plays in mediating inflammatory responses, the inhibitory effects of baicalein on iNOS suggest that baicalein may represent a useful anti-inflammatory agent.
Use of Social Network Sites and Instant Messaging Does Not Lead to Increased Offline Social Network Size, or to Emotionally Closer Relationships with Offline Network Members

The effect of Internet use on social relationships is still a matter of intense debate. This study examined the relationships between use of social media (instant messaging and social network sites), network size, and emotional closeness in a sample of 117 individuals aged 18 to 63 years old. Time spent using social media was associated with a larger number of online social network "friends. " However, time spent using social media was not associated with larger offline networks, or feeling emotionally closer to offline network members. Further, those that used social media, as compared to non-users of social media, did not have larger offline networks, and were not emotionally closer to offline network members. These results highlight the importance of considering potential time and cognitive constraints on offline social networks when examining the impact of social media use on social relationships.
Historical fragmentation of islands and genetic drift in populations of Galápagos lava lizards (Microlophus albemarlensis complex)

The formation of islands following a rise in sea level at the end of Pleistocene is expected to disrupt the equilibrium between genetic drift and gene flow in species with limited ability to disperse. Here, we test the hypothesis that genetic drift in isolation has caused the differentiation of Galápagos lava lizards (Microlophus albemarlensis complex) found on 12 islets that are likely to have been connected to a larger island, Isla Santa Cruz, during the late Pleistocene. Using 11 microsatellite loci, screened on 524 individuals from 17 localities distributed among and within 15 islands, we found marked differences in allelic richness and heterozygosity. Genetic differentiation was strong (global FST = 0.44), with pairwise differences found among populations on islets being larger than differences among three localities sampled within Isla Santa Cruz. As expected under a scenario of drift in isolation, there was a positive correlation of genetic diversity with island size, no relationship between genetic and geographical distance and a strong negative correlation between heterozygosity and measures of genetic differentiation. We conclude that seawater is a significant barrier to gene flow in lava lizards on this timescale. Our results suggest that the shallow diversification of the M. albemarlensis complex is not due to recent gene flow and that genetic drift may have played a substantial role in observed patterns of phenotypic variation among islands.
Conjugacy and counterexample in random iteration

We consider counterexamples in the field of random iteration to two well-known theorems of classical complex dynamics - Sullivan's non-wandering theorem and the classification of periodic Fatou components. Random iteration which was first introduced by Fornaess and Sibony (1991) is a generalization of standard complex dynamics where instead of considering iterates of a fixed rational function, one allows the mappings to vary at each stage of the iterative process. In this setting one can produce oscillatory behaviour of a type forbidden in classical rational iteration. The technique of the proof requires us to extend the classical notion of conjugacy between dynamical systems to random iteration and we prove some basic results concerning conjugacy in this setting.
Guidelines for Constructing Consumption Aggregates for Welfare Analysis

An analyst using household survey data to construct a welfare metric is often confronted with onfronted with An analyst using household survey data to construct a welfare metric is often confronted with a number of theoretical and practical problems. What components should be included in the overall welfare measure? Should differences in tastes be taken into account when making comparisons across people and households? How best should differences in cost-of-living and household composition be taken into consideration? Starting with a brief review of the theoretical framework underpinning typical welfare analysis undertaken based on household survey data, this paper provides some practical guidelines and advice on how best to tackle such problems. It outlines a three-part procedure for constructing a consumption-based measure of individual welfare: 1) aggregation of different components of household consumption to construct a nominal consumption aggregate; 2) construction of price indices to adjust for differences in prices faced by households; and 3) adjustment of the real consumption aggregate for differneces in household composition. Examples based on survey data fro eight countries--Ghana, Vietnam, Nepal, the Kyrgyz Republic, Ecuador, South Africa, Panama, and Brazil--are used to illustrate the various steps involved in constructing the welfare measure, and the STATA programs used for this purpose are provided in the appendix. The paper also includes examples of some analytic techniques used to examine the robustness of the estimated welfare measure to underlying assumptions.
The Last Mile: How to Sustain Long‐Distance Migration in Mammals

Abstract: Among Earth's most stunning, yet imperiled, biological phenomena is long‐distance migration (LDM). Although the understanding of how and why animals migrate may be of general interest, few site‐specific strategies have targeted ways in which to best retain such increasingly rare events. Contrasts among 29 terrestrial mammals from five continents representing 103 populations indicate that remnant long‐distant migrants have poor long‐term prospects. Nonetheless, in areas of low human density in the Western Hemisphere, five social and nongregarious species, all from the same region of the Rocky Mountains (U.S.A.), still experience the most accentuated of remaining New World LDMs south of central Canada. These movements occur in or adjacent to the Greater Yellowstone region, where about 75% of the migration routes for elk (Cervus elaphus), bison ( Bison bison), and North America's sole surviving endemic ungulate, pronghorn (Antilocapra americana), have already been lost. However, pronghorn still migrate up to 550 km (round‐trip) annually. These extreme movements (1) necessitate use of historic, exceptionally narrow corridors (0.1–0.8 km wide) that have existed for at least 5800 years, (2) exceed travel distances of elephants ( Loxodonta africana) and zebras ( Equus burchelli), and (3) are on par with those of Asian chiru ( Pantholops hodgsoni) and African wildebeest (Connochaetes taurinus). Although conservation planners face uncertainty in situating reserves in the most biologically valued locations, the concordance between archaeological and current biological data on migration through specific corridors in these unprotected areas adjacent to the Yellowstone system highlights their retention value. It is highly likely that accelerated leasing of public lands for energy development in such regions will truncate such migrations. One landscape‐level solution to conserving LDMs is the creation of a network of national migration corridors, an action in the Yellowstone region that would result in de facto protection for a multispecies complex. Tactics applied in this part of the world may not work in others, however, therefore reinforcing the value of site‐specific field information on the past and current biological needs of migratory species.
Inflammation Activation Contributes to Adipokine Imbalance in Patients with Acute Coronary Syndrome

Inflammation can be activated as a defensive response by the attack of acute coronary syndrome (ACS) for ischemic tissue injury. The aim of the present study was to investigate the impact of ACS-activated inflammation on adipokine imbalance and the effects of statins on the crosstalk between inflammation and adipokine imbalance during ACS. In this study, 586 subjects were categorized into: (1) control group; (2) SA (stable angina) group; and (3) ACS group. Circulating levels of hs-CRP, adiponectin and resistin were measured by ELISA. Furthermore, forty C57BL/6 mice were randomized into: sham, AMI, low-statin (atorvastatin, 2 mg/kg/day) and high-statin (atorvastatin, 20 mg/kg/day) group. After 3 weeks, AMI models were established by surgical coronary artery ligation. Circulating levels and adipose expressions of adiponectin and resistin were assessed in animals. Besides, we investigate the effects of atorvastatin on ox-LDL-induced adipokine imbalance in vitro. As a result, we found that ACS patients had higher hs-CRP and resistin levels and lower adiponectin levels. Our correlation analysis demonstrated hs-CRP concentrations were positively correlated with resistin but negatively with adiponectin levels in humans. Our animal findings indicated higher circulating hs-CRP and resistin levels and lower adiponectin levels in AMI mice. Atorvastatin pre-treatment dose-dependently decreased hs-CRP and resistin levels but increased adiponectin levels in mice. The consistent findings were observed about the adipose expressions of resistin and adiponectin in mice. In study in vitro, ox-LDL increased cellular resistin expressions and otherwise for adiponectin expressions, which dose-dependently reversed by the addition of atorvastatin. Therefore, our study indicates that the ACS attack activates inflammation leading to adipokine imbalance that can be ameliorated by anti-inflammation of atorvastatin.
IIB solutions with N > 28 Killing spinors are maximally supersymmetric

We show that all IIB supergravity backgrounds which admit more than 28 Killing spinors are maximally supersymmetric. In particular, we find that for all N>28 backgrounds the supercovariant curvature vanishes, and that the quotients of maximally supersymmetric backgrounds either preserve all 32 or N<29 supersymmetries.
PocketNavigator: studying tactile navigation systems in-situ

In this paper, we report about a large-scale in-situ study of tactile feedback for pedestrian navigation systems. Recent advances in smartphone technology have enabled a number of interaction techniques for smartphone that use tactile feedback to deliver navigation information. The aim is to enable eyes-free usage and avoid distracting the user from the environment. Field studies where participants had to fulfill given navigation tasks, have found these techniques to be efficient and beneficial in terms of distraction. But it is not yet clear whether these findings will replicate in in-situ usage. We, therefore, developed a Google Maps-like navigation application that incorporates interaction techniques proposed in previous work. The application was published for free on the Android Market and so people were able to use it as a navigation system in their everyday life. The data collected through anonymous monitoring suggests that tactile feedback is successfully adopted in one third of all trips and has positive effects on the user's level of distraction.
Evaluating the Maastricht Convergence Criteria for New Prospective European Union Members

This paper aims to assess the macroeconomic condition of the four new prospective members, which are Turkey, Croatia, Bulgaria, and Romania, depending on four Maastricht Convergence Criteria in order to determine which candidate is ready to join EMU. We use cointegration approach to analyze cointegrating relations among inflation rates, interest rate, deficit-to-GDP, and debt-to-GDP ratios of four candidates in relation to Germany. Bounds Testing and Engle-Granger Cointegration Approach are applied to all criteria to test convergence. None of the convergence criteria for Turkey and Romania in relation to Germany has been achieved. On the other hand, there is evidence of nominal convergence between Croatia and Germany in terms of deficit-to-GDP ratio and interest rates. Also, there is cointegration between deficit-to-GDP ratio of Bulgaria and that of Germany.
Undergraduate Borrowing: A Study of Debtor Students and Their Ability to Retire Undergraduate Loans

Steven A. Harrast is assistant professor of accounting for the University of Northern Iowa. This study finds that at one university, college major, ethnicity, grade point average, age, and number of semesters required to complete a degree are relevant in determining the student loan debts of recent college graduates. Gender is found to be irrelevant in determining student loan balances. A large percentage of recent graduates have student loans in excess of lender-recommended levels leading to concerns that the benefits of higher education are being slowly eroded by the increasing debt burdens of graduates.
Improved methods for blastocyst formation and culture.

Transfer at the blastocyst stage has been proposed to increase the pregnancy rates after in-vitro fertilization (IVF) and embryo transfer. In the first period of experiments, culture in a single medium, from fertilization to blastocyst led to disappointing results: low blastocyst formation rates and low implantation rates per blastocyst transferred. Then the period of co-culture began (starting with animals in the early 1980s and with humans in the early 1990s). With this technique, using tubal or granulosa cells or layers obtained from established cell lines of transport epithelium origin, blastocyst formation has reached approximately 50% and the overall implantation rate is approximately 25%. The embryos obtained have high numbers of cells (> 200 cells for a day 6 expanded blastocyst). Co-culture with fibroblasts has been found to be useless. This technology has been proven reliable and reproducible: Blastocyst formation is highly dependent on maternal and paternal factors. It has enabled the design of efficient freezing and thawing protocols. Numerous interesting observations have been obtained to reach the third period, i.e. the use of sequential media. A simple medium is used for fertilization, then another one is used from fertilization up to the 4-cell stage (beginning of waves of transcription), then a third medium is used for development up to the blastocyst stage. The results obtained seem very similar to the one obtained with co-culture. Obviously it is now time, in humans, to switch to sequential media.
Power Optimization via Post-Link-Time Binary Rewriting Saumya Debray

It is well known that compiler optimizations can significantly reduce the energy usage of a program. However, the traditional model of compilation imposes inherent limits on the extent of code optimization possible at compile time. In particular, analyses and optimizations are typically limited to individual procedures, and hence cannot cross procedural and module boundaries as well as the boundaries between application and library code. These limitations can be overcome by carrying out additional code optimization on the object file obtained after linking has been carried out. These optimizations are complementary to those carried out by the compiler. Our experiments indicate that significant improvements in energy usage can be obtained via post-link-time code optimization, even for programs that have been subjected to extensive compile-time optimization.
A New Lossy Substrate Model for Accurate RF CMOS Noise Extraction and Simulation With Frequency and Bias Dependence

A lossy substrate model is developed to accurately simulate the measured RF noise of 80-nm super-100-GHz fT n-MOSFETs. A substrate RLC network built in the model plays a key role responsible for the nonlinear frequency response of noise in 1-18-GHz regime, which did not follow the typical thermal noise theory. Good match with the measured S-parameters, Y-parameters, and noise parameters before deembedding proves the lossy substrate model. The intrinsic RF noise can be extracted easily and precisely by the lossy substrate deembedding using circuit simulation. The accuracy has been justified by good agreement in terms of Id,gm, Y-parameters, and f T under a wide range of bias conditions and operating frequencies. Both channel thermal noise and resistance induced excess noises have been implemented in simulation. A white noise gamma factor extracted to be higher than 2/3 accounts for the velocity saturation and channel length modulation effects. The extracted intrinsic NFmin as low as 0.6-0.7 dB at 10 GHz indicates the advantages of super-100 GHz fT offered by the sub-100-nm multifinger n-MOSFETs. The frequency dependence of noise resistance Rn suggests the bulk RC coupling induced excess channel thermal noise apparent in 1-10-GHz regime. The study provides useful guideline for low noise and low power design by using sub-100-nm RF CMOS technology
A distance-based feature-encoding technique for protein sequence classification in bioinformatics

Bioinformatics has been emerging as a new research dimension since the last century by combining computer science and biology techniques for the automatic analysis of biological sequence data. The volume of the biological data gathered under different sequencing projects is increasing exponentially. These sequences contain extremely important information about genes, their structure and function. Computational techniques which involve machine learning and pattern recognition are becoming very useful on Bioinformatics data like DNA and protein. Protein classification into different groups could be used for knowing the structure or the function of unknown protein sequence. The process of classifying protein amino acid sequences into a family /superfamily is a very complex problem. However, from among other major issues in a protein classification, the critical one is an accurate representation of amino acid sequence during the feature extraction. In this work, we have proposed a distance-based feature-encoding method; the proposed technique has been tested with different classifiers, which have shown better results than the previously available techniques for superfamily classification of protein sequences. The maximum average classification accuracy obtained was 91.2%. The dataset used in the experiments was taken from the well known UniProtKB protein database.
Role of balloon occlusion for mononuclear bone marrow cell deposition after intracoronary injection in pigs with reperfused myocardial infarction.

AIMS In clinical studies on cell therapy for acute myocardial infarction (MI), cells are usually applied by intracoronary infusion with balloon (IC/B). To test the utility of balloon occlusion, mononuclear bone marrow cell (MNC) retention after intracoronary infusion without balloon (IC/noB) was compared with IC/B and intramyocardial (IM) injection. METHODS AND RESULTS Four hours after LAD ligation in male pigs, reperfusion was allowed (confirmed by coronary angiography). Five days later, 1 x 10(8) autologous (111)Indium-labelled MNC were injected IC/noB (n = 4), IC/B (n = 4), or IM (n = 4). At 1 h the fraction of injected MNC that was detected in the heart was 4.1 +/- 1.1% after IC/noB injection, 6.1 +/- 2.5% after IC/B injection (P = 0.19), and 20.7 +/- 2.3% after IM injection (P < 0.001 vs. IC/noB and IC/B). At 24 h it was 3.0 +/- 0.6% (IC/noB), 3.3 +/- 0.5% (IC/B, P = 0.43), and 15.0 +/- 3.1% (IM, P < 0.001 vs. IC/noB and IC/B). Dynamic scintigrammes during each of four consecutive IC/B injections showed a rapid 19.6 +/- 8.0% cell loss during balloon inflation (no-flow period, phase 1) and a rapid 36.6 +/- 17.8% cell loss after balloon deflation (re-flow period, phase 2). After each of four consecutive IC/noB injections the peak cell deposit was lower, followed by one phase of rapid cell loss (30.9 +/- 11.0% after 6 min). After IM injection only a slow linear cell loss was observed (9.7% per h). In histology, PKH-67 labelled cells only rarely had passed the endothelial barrier after 24 h after IC injection, while they were exclusively found in the interstitium after IM injection. CONCLUSION The observation of a similar cell persistence after IC injections with and without balloon occlusion suggests that the balloon procedures currently applied in clinical studies are not necessary for cell deposit. If longer term persistence of cells plays a role for the clinical benefit of cardiac cell therapy, IM injection may be superior to IC applications.
High Perfomance Communication Protocol for Wireless Ad-Hoc Sensor Networks

In order to monitor for traffic traversal, sensors can be deployed to perform collaborative target detection. Such a sensor network achieves a certain level of detection performance with the associated costs of deployment and routing protocol. This paper addresses these two points of sensor deployment and routing algorithm in the situation where the absolute quantity of sensors or total energy becomes insufficient. This discussion on the best deployment system concluded that two kinds of deployments; Normal and Power law distributions, show 6 and 3 times longer than Random distribution in the duration of coverage, respectively. The other discussion on routing algorithm to achieve good performance in each deployment system was also addressed. This discussion concluded that, in place of the traditional algorithm, a new algorithm can extend the time of coverage duration by 4 times in a Normal distribution, and in the circumstance where every deployed sensor operates as a binary model. Keywords—binary sensor, coverage rate, power energy consumption, routing algorithm, sensor deployment