Miracle-dz/UniFAR-FTUs huggingface dataset:
Support Efficient and Fault-Tolerant Multicast in Bufferless Network-on-Chip

In this paper, we propose three Deflection-Routing-based Multicast (DRM) schemes for a bufferless NoC. The DRM scheme without packets replication (DRM_noPR) sends multicast packet through a non-deterministic path. The DRM schemes with adaptive packets replication (DRM_PR_src and DRM_PR_all) replicate multicast packets at the source or intermediate node according to the destination position and the state of output ports to reduce the average multicast latency. We also provide fault-tolerant supporting in these schemes through a reinforcement-learning-based method to reconfigure the routing table to tolerate permanent faulty links in the network. Simulation results illustrate that the DRM_PR_all scheme achieves 41%, 43% and 37% less latency on average than that of the DRM_noPR scheme and 27%, 29% and 25% less latency on average than that of the DRM_PR_src scheme under three synthetic traffic patterns respectively. In addition, all three fault-tolerant DRM schemes achieve acceptable performance degradation at various link fault rates without any packet lost.
Assessment of Effects of Si-Ca-P Biphasic Ceramic on the Osteogenic Differentiation of a Population of Multipotent Adult Human Stem Cells

A new type of bioceramic with osteogenic properties, suitable for hard tissue regeneration, was synthesised. The ceramic was designed and obtained in the Nurse’s A-phase-silicocarnotite subsystem. The selected composition was that corresponding to the eutectoid 28.39 wt % Nurse’s A-phase-71.61 wt % silicocarnotite invariant point. We report the effect of Nurse’s A-phase-silicocarnotite ceramic on the capacity of multipotent adult human mesenchymal stem cells (ahMSCs) cultured under experimental conditions, known to adhere, proliferate and differentiate into osteoblast lineage cells. The results at long-term culture (28 days) on the material confirmed that the undifferentiated ahMSCs cultured and in contact with the material surface adhered, spread, proliferated, and produced a mineralised extracellular matrix on the studied ceramic, and finally acquired an osteoblastic phenotype. These findings indicate that it underwent an osteoblast differentiation process. All these findings were more significant than when cells were grown on plastic, in the presence and absence of this osteogenic supplement, and were more evident when this supplement was present in the growth medium (GM). The ceramic evaluated herein was bioactive, cytocompatible and capable of promoting the proliferation and differentiation of undifferentiated ahMSCs into osteoblasts, which may be important for bone integration into the clinical setting.
Comprehensive genomic profiling aids in treatment of a metastatic endometrial cancer

FGFR-TACC fusions, including FGFR3-TACC3, have been identified as potential oncogenic drivers and actionable alterations in a number of different cancer types. The clinical relevance of FGFR3-TACC3 fusions in endometrial cancer has not yet been described. Formalin-fixed, paraffin-embedded metastatic endometrial carcinoma from the spleen and peritoneum were sent for comprehensive genomic profiling (CGP) using the FoundationOne platform as part of a prospective tumor genomic profiling protocol. We report the identification of an FGFR3-TACC3 fusion in a case of metastatic endometrioid endometrial cancer. Other potentially actionable alterations detected in this specimen included PIK3CA T1025S and an uncharacterized rearrangement involving TSC2. The patient initially received an FGFR inhibitor as an investigational agent and experienced stable disease with complete resolution of a pelvic nodule; however, treatment had to be discontinued because of intolerable side effects. A PET/CT scan nearly 3 mo after discontinuation showed disease progression. She subsequently received the mTOR inhibitor, temsirolimus, later accompanied by letrozole, and achieved stable disease. Clinical benefit was attributed to the mTOR inhibitor as tumor stained negative for estrogen receptor. Temsirolimus was discontinued after >17 mo because of disease progression. FGFR inhibitors may have clinical benefit in the treatment of endometrial carcinoma with FGFR3-TACC3 fusions. Additionally, clinical benefit from an mTOR inhibitor may reflect a response to targeting the alteration in PIK3CA or TSC2. More research is needed to understand the activity of FGFR3-TACC3 fusions on tumors and to discover additional therapeutic options for endometrial carcinoma patients with this gene fusion.
Hepatitis C Virus Frameshift/Alternate Reading Frame Protein Suppresses Interferon Responses Mediated by Pattern Recognition Receptor Retinoic-Acid-Inducible Gene-I

Hepatitis C virus (HCV) actively evades host interferon (IFN) responses but the mechanisms of how it does so are not completely understood. In this study, we present evidence for an HCV factor that contributes to the suppression of retinoic-acid-inducible gene-I (RIG-I)-mediated IFN induction. Expression of frameshift/alternate reading frame protein (F/ARFP) from HCV -2/+1 frame in Huh7 hepatoma cells suppressed type I IFN responses stimulated by HCV RNA pathogen-associated molecular pattern (PAMP) and poly(IC). The suppression occurred independently of other HCV factors; and activation of interferon stimulated genes, TNFα, IFN-λ1, and IFN-λ2/3 was likewise suppressed by HCV F/ARFP. Point mutations in the full-length HCV sequence (JFH1 genotype 2a strain) were made to introduce premature termination codons in the -2/+1 reading frame coding for F/ARFP while preserving the original reading frame, which enhanced IFNα and IFNβ induction by HCV. The potentiation of IFN response by the F/ARFP mutations was diminished in Huh7.5 cells, which already have a defective RIG-I, and by decreasing RIG-I expression in Huh7 cells. Furthermore, adding F/ARFP back via trans-complementation suppressed IFN induction in the F/ARFP mutant. The F/ARFP mutants, on the other hand, were not resistant to exogenous IFNα. Finally, HCV-infected human liver samples showed significant F/ARFP antibody reactivity, compared to HCV-uninfected control livers. Therefore, HCV F/ARFP likely cooperates with other viral factors to suppress type I and III IFN induction occurring through the RIG-I signaling pathway. This study identifies a novel mechanism of pattern recognition receptor modulation by HCV and suggests a biological function of the HCV alternate reading frame in the modulation of host innate immunity.
Low latency low power bit flipping algorithms for LDPC decoding

Low Density Parity Check (LDPC) codes have been adopted in a number of wired and wireless communication standards due to their improved error correcting ability and relatively simple decoder structure. However, for very high throughput systems operating in the multi-Gb/s range conventional decoding methods based on message passing are limited, due largely to the sheer volume of messages being exchanged. Thus, simpler decoding methods have been proposed such as bit flipping permitting efficient and fast hardware implementation. This paper presents two new bit flipping algorithm designed to reduce latency and power consumption. For a small loss in bit error rate performance (0.5 dB) we show how the application of an early stopping criteria uses 89% fewer iterations compared to a similar published algorithm. We also present a method for reducing power consumption by placing processing elements into a quiescent state based on a bit-local metric. Using this technique we show a potential reduction in power consumption of 76%.
Covariance mapping techniques

Recent technological advances in the generation of intense femtosecond pulses have made covariance mapping an attractive analytical technique. The laser pulses available are so intense that often thousands of ionisation and Coulomb explosion events will occur within each pulse. To understand the physics of these processes the photoelectrons and photoions need to be correlated, and covariance mapping is well suited for operating at the high counting rates of these laser sources. Partial covariance is particularly useful in experiments with x-ray free electron lasers, because it is capable of suppressing pulse fluctuation effects. A variety of covariance mapping methods is described: simple, partial (single- and multi-parameter), sliced, contingent and multi-dimensional. The relationship to coincidence techniques is discussed. Covariance mapping has been used in many areas of science and technology: inner-shell excitation and Auger decay, multiphoton and multielectron ionisation, time-of-flight and angle-resolved spectrometry, infrared spectroscopy, nuclear magnetic resonance imaging, stimulated Raman scattering, directional gamma ray sensing, welding diagnostics and brain connectivity studies (connectomics). This review gives practical advice for implementing the technique and interpreting the results, including its limitations and instrumental constraints. It also summarises recent theoretical studies, highlights unsolved problems and outlines a personal view on the most promising research directions.
Detection of CK 19 mRNA in the blood of breast cancer Female Egyptian patients and its relation to established prognostic parameters

Purpose Breast cancer is a leading cause of cancer-related deaths in women Worldwide. The clinical course of this disease is highly variable and clinicians continuously search for prognostic parameters that can accurately predict prognosis. peripheral blood cytokeratin-19 (CK-19) mRNA-positive cells and its correlation with well established prognostic factors including pathologic parameters, hormonal status and biologic marker; HER 2/ neu in breast female Egyptian cancer patients was studied . Patients and Methods A total of 60 peripheral blood specimens were collected for study. Patients were forty newly diagnosed breast cancer and 10 patients with benign breast lesions . The10 apparently healthy donors and patients with benign lesions were used as the control group. They were analyzed for the presence of CK-19 mRNA-positive cells using nested reverse transcription polymerase chain reaction assay (RT-PCR). Immunohistochemical staining for HER 2/neu, estrogen and progesterone receptors were carried out for all cases. The association with known prognostic factors and the effect of CK-19 mRNApositive cells on patients' prognosis was investigated. Results CK-19 mRNA-positive cells were detected in the blood of 14 patients (35%) of the 40 patients. There was statistically significant association between the presence of CK19 mRNA-positive cells and the patients’ tumor size and histologic grade of the tumor, stage of disease and the involved lymph nodes P =<0.001, 0.006 , 0.007and0. 005 respectively. CK-19 mRNA-positive cell detection also showed high significance with HER2 expression receptor (p=0.001). None of the patients with CK 19 positive cells expressed dual ER & PR positivity being both negative and either negative. There was no statistically significantly association between the detection of CK19 mRNA-positive cells and patient’s age, menstrual status or pathologic type. Conclusion: Peripheral-blood CK-19 mRNA-positive cells might constitute a biologically active subset of breast cancer patients with high tumor burden and bad prognosis. [Amal F. M. Said ; Iman l. H. Abulkheir ; Amany Helaland Dalia B. Mohammad. Detection of CK19 mRNA in the blood of breast cancer Female Egyptian patients and its relation to established prognostic parameters. ] Life Science Journal 2012; 9(1):561-571]. (ISSN: 1097-8135). http://www.lifesciencesite. com. 84
Molecular phylogeny of gill monogeneans ( Platyhelminthes , Monogenea , Dactylogyridae ) and colonization of Indo-West Pacific butterflyfish hosts ( Perciformes , Chaetodontidae )

425 Plaisance, L. , Littlewood, D. T. J., Olson, P. D. & Morand, S. (2005). Molecular phylogeny of gill monogeneans (Platyhelminthes, Monogenea, Dactylogyridae) and colonization of Indo-West Pacific butterflyfish hosts (Perciformes, Chaetodontidae). — Zoologica Scripta, 34, 425–436. We investigated the phylogenetic relationships among monogenean parasites of the Chaetodontidae (butterflyfishes) from the Indo-West Pacific Ocean. Molecular phylogenies of selected taxa within the Dactylogyridae, including the ancyrocephaline parasites of butterflyfishes, based on two nuclear and one mitochondrial gene fragments (complete 18S rDNA, partial 28S rDNA (D1-D3), and partial 16S rDNA) were reconstructed using parsimony, maximum likelihood and Bayesian inference methods. Our results show the non-monophyletic nature of the monogenean fauna of butterflyfishes. The group is divided into two independent lineages. The first clade contains species of the genera Aliatrema and Euryhaliotrematoides , which parasitize Chaetodontidae exclusively. The second contains species of Haliotrema , a generalist group of parasites. The positions of several other species of the Ancyrocephalinae, including freshwater species, at the base of the two clades, provide strong evidence that the monogenean fauna did not result from a single colonization event, but rather that they have colonized their butterflyfish hosts independently at least twice. Laetitia Plaisance, UMR 5555 CNRS-UP, Parasitologie Fonctionelle et Evolutive, CBTEM, Université, 52 Avenue Paul Alduy, 66860 Perpignan Cedex, France. E-mail: plaisanc@univ-perp.fr D. Timothy J. Littlewood and Peter D. Olson, Parasitic Worms Division, Department of Zoology, The Natural History Museum, Cromwell Road, London SW7 5BD, UK. E-mail: t.littlewood@nhm.ac. uk; p.olson@nhm.ac. uk Serge Morand, Centre de Biologie et de Gestion des Populations, Campus international de Baillarguet, CS 30016, 34988 Montferrier-sur-Lez cedex, France. E-mail: morand@ensam.inra. fr Blackwell Publishing, Ltd. Molecular phylogeny of gill monogeneans (Platyhelminthes, Monogenea, Dactylogyridae) and colonization of Indo-West Pacific butterflyfish hosts (Perciformes, Chaetodontidae)
FoN: Fault-on-Neighbor aware routing algorithm for Networks-on-Chip

Reliability has become a key issue of Networks-on-Chip (NoC) as the CMOS technology scales down to the nanoscale domain. This paper proposes a Fault-on-Neighbor (FoN) aware deflection routing algorithm for NoC which makes routing decision based on the link status of neighbor switches within 2 hops to avoid fault links and switches. Simulation results demonstrate that in the presence of faults, the saturated throughput of the FoN switch is 13% higher on average than a cost-based deflection switch for 8×8 mesh. The average hop counts can be up to 1.7× less than the cost-based switch. The FoN switch is also synthesized using 65nm TSMC technology and it can work at 500MHz with small area overhead.
Simplified models of the symmetric single-pass parallel-plate counterflow heat exchanger: a tutorial

The heat exchanger is important in practical thermal processes, especially those of (i) the molten-salt storage schemes, (ii) compressed air energy storage schemes and (iii) other load-shifting thermal storage presumed to undergird a Smart Grid. Such devices, although central to the utilization of energy from sustainable (but intermittent) renewable sources, will be unfamiliar to many scientists, who nevertheless need a working knowledge of them. This tutorial paper provides a largely self-contained conceptual introduction for such persons. It begins by modelling a novel quantized exchanger,1 impractical as a device, but useful for comprehending the underlying thermophysics. It then reviews the one-dimensional steady-state idealization which demonstrates that effectiveness of heat transfer increases monotonically with (device length)/(device throughput). Next, it presents a two-dimensional steady-state idealization for plug flow and from it derives a novel formula for effectiveness of transfer; this formula is then shown to agree well with a finite-difference time-domain solution of the two-dimensional idealization under Hagen–Poiseuille flow. These results are consistent with a conclusion that effectiveness of heat exchange can approach unity, but may involve unwelcome trade-offs among device cost, size and throughput.
FATIGUE BEHAVIOUR OF BONDED FRP USED FOR FLEXURAL RETROFIT

A review of previous studies of the fatigue behaviour of FRP-retrofit members is presented. The intent of this review is to identify behaviour associated with FRP debonding in members subject to fatigue loading conditions. The effects of different specimen loading geometry (particularly shear span-to-depth ratios), retrofit type and geometry, and specimen size are discussed in the context of their relation to debonding behaviour and their effects on observed S-N behaviour of reinforced concrete sections subject to flexural fatigue. The present paper attempts to provide some guidance with respect to the nature of the fatigue behaviour of FRP retrofit concrete beams and the experimental parameters by which this behaviour is established.
Airway registry and training curriculum improve intubation outcomes in the intensive care unit

Background: Intubation in critically ill patients remains a highly morbid procedure, and the optimal approach is unclear. We sought to improve the safety of intubation by implementing a simulation curriculum and monitoring performance with an airway registry. Methods and Methods: This is a prospective, single-center observational study of all intubations performed by the medical intensive care unit (ICU) team over a five-year period. All fellows take part in a simulation curriculum to improve airway management performance and minimize complications. An airway registry form is completed immediately after each intubation to capture relevant patient, operator, and procedural data. Results: Over a five-year period, the medical ICU team performed 1411 intubations. From Year 1 to Year 5, there were significant increases in first-attempt success (72.6 vs. 88.0%, p<0.001), use of video laryngoscopy (72.3 vs. 93.5%, p<0.001), and use of neuromuscular blocking agents (73.5 vs. 88.4%, p<0.001). There were concurrent decreases in rates of desaturation (25.6 vs. 17.1%, p=0.01) and esophageal intubations (5 vs. 1%, p=0.009). Low rates of hypotension (8.3%) and cardiac arrest (0.6%) were also observed. Conclusions: The safety of intubation in critically ill patients can be markedly improved through joint implementation of an airway registry and simulation curriculum.
Prevention by NCX 4016, a nitric oxide-donating aspirin, but not by aspirin, of the acute endothelial dysfunction induced by exercise in patients with intermittent claudication

Summary Ischemia/reperfusion damage evokes systemic inflammation and endothelial dysfunction in patients with intermittent claudication. We compared the effects of aspirin with those of a nitric oxide-donating aspirin in preventing the acute, systemic endothelial dysfunction provoked by exercise-induced ischemia of the lower limbs in patients with intermittent claudication. In a prospective, randomized, single-blind, parallel-groups trial among 44 patients with intermittent claudication we compared four weeks of aspirin (100 mg o.d.) with NCX 4016 (800 mg b.i.d.). Primary end point was the exercise-induced changes in brachial flow-mediated vasodilation (FMD) at day 28; secondary end points were effort-induced changes of markers of neutrophil (plasma elastase) and endothelial (soluble VCAM-1) activation. Baseline FMD was comparable in the two groups, both on day I (pre-treatment: aspirin = 3.1 ± 0.5%, nitroaspirin = 3.9 ± 0.7%, p=NS), and on day 28 (aspirin = 3.4 ± 0.7%, NCX 4016 = 3.2 ± 0.6%, p=NS). Maximal treadmill exercise induced an acute worsening of FMD in both groups at baseline (aspirin = –1.15%, nitroaspirin = –1.76%); after four weeks treatment, the impairment of FMD induced by exercise was still present in the aspirin-treated group (- 1.46%) while it was abolished in the NCX 4016-treated group (+ 0.79%, p= 0.038 vs. aspirin). Similarly, exercise induced an increase of plasma elastase and of sVCAM-l which were not affected by aspirin while they were suppressed by NCX 4016. Maximal treadmill exercise induces a systemic arterial endothelial dysfunction in patients with intermittent claudication. A nitric oxide-donating aspirin, but not aspirin, prevents effort-induced endothelial dysfunction.
TITLE: Emerging Technologies for the Prevention of Pressure Ulcers in Acute Care Settings: A Review of Clinical and Cost-Effectiveness and Guidelines

Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic review s. The intent is to provide a list of sources of the best evidence on the topic that the Canadian Agency for Drugs and Technologies in Health (CADTH) could identify using all reasonable efforts within the time allow ed. Rapid responses should be considered along w ith other ty pes of information and health care considerations. The information included in this response is not intended to replace professional medical advice, nor should it be construed as a recommendation for or against the use of a particular health technology. Readers are also cautioned that a lack of good quality evidence does not necessarily mean a lack of effectiveness particularly in the case of new and emerging health technologies, for w hich little information can be found, but w hich may in future prove to be effective. While CADTH has taken care in the preparation of the report to ensure that its contents are accurate, complete and up to date, CADTH does not make any guarantee to that effect. CADTH is not liable for any loss or damages resulting from use of the information in the report.
Localisation des caméras ANPR sur le réseau routier pour le profilage géographique

Malgre un recours croissant a la technologie des cameras ANPR, en particulier dans les investigations criminelles, la litterature et l’experience des forces de police avec lesquelles nous avons travaille, semblent montrer qu’il n’existe pas de methode systematique afin de localiser le plus adequatement possible ces installations couteuses. Partant d’un ensemble de delits localises, relevant de quatre categories de vols perpetres sur une annee au sein de la province de Liege (Belgique), nous proposons une methodologie exploitant, dans une analyse multicritere, la densite de delits, la densite de voirie et la distance entre les sites des cameras. L’approche multicritere permet d’ajuster la ponderation des facteurs selon les types de delits. En outre, la methodologie est iterative, dans la mesure ou les sites des cameras sont localises par phases successives. Un critere de validation des resultats est fourni sous la forme d’un taux de couverture du territoire considere, qui est fonction du nombre de sites de cameras retenus et du temps de parcours depuis chacun de ces sites. De plus, les consequences des tentatives d’evitement des sites installes en matiere de profilage geographique sont rapidement evoquees.
The Influence of Voids on the Engineering Constants of Oriented Strandboard: A Finite Element Model

A laminated model based on continuum theory combined with finite-element analysis (FEA) was used to predict the influence of voids on engineering constants of oriented strandboard (OSB). Cylindrical voids with three material density classes in the void region were considered at various void volume fractions (VVFs) and matrix anisotropies. It was found that the presence of voids resulted in substantial decreases in the elastic moduli and Poisson ratio of OSB. The hygroexpansion coefficients were affected little by voids. The elastic constants normalized with their void-free (matrix) values were found to depend little on the anisotropy of the matrix, especially at high VVFs. Increases of material density in the void region led to increases in predicted elastic constants. The predicted moduli values for the void models with certain material densities correlated well with available experimental data for the selected panel structures. The FEA provided a comprehensive numerical tool in predicting localized elastic properties of porous OSB. The model is the basis for modeling three-layer boards and for constructing in-plane modulus map of full-size panels.