Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of Constitutive Behavior and Tumor-Host Mechanical Interactions in the State of Stress and Growth of Solid Tumors

Mechanical forces play a crucial role in tumor patho-physiology. Compression of cancer cells inhibits their proliferation rate, induces apoptosis and enhances their invasive and metastatic potential. Additionally, compression of intratumor blood vessels reduces the supply of oxygen, nutrients and drugs, affecting tumor progression and treatment. Despite the great importance of the mechanical microenvironment to the pathology of cancer, there are limited studies for the constitutive modeling and the mechanical properties of tumors and on how these parameters affect tumor growth. Also, the contribution of the host tissue to the growth and state of stress of the tumor remains unclear. To this end, we performed unconfined compression experiments in two tumor types and found that the experimental stress-strain response is better fitted to an exponential constitutive equation compared to the widely used neo-Hookean and Blatz-Ko models. Subsequently, we incorporated the constitutive equations along with the corresponding values of the mechanical properties - calculated by the fit - to a biomechanical model of tumor growth. Interestingly, we found that the evolution of stress and the growth rate of the tumor are independent from the selection of the constitutive equation, but depend strongly on the mechanical interactions with the surrounding host tissue. Particularly, model predictions - in agreement with experimental studies - suggest that the stiffness of solid tumors should exceed a critical value compared with that of the surrounding tissue in order to be able to displace the tissue and grow in size. With the use of the model, we estimated this critical value to be on the order of 1.5. Our results suggest that the direct effect of solid stress on tumor growth involves not only the inhibitory effect of stress on cancer cell proliferation and the induction of apoptosis, but also the resistance of the surrounding tissue to tumor expansion.
A Risk Function for Behavioral Disruption of Blainville’s Beaked Whales (Mesoplodon densirostris) from Mid-Frequency Active Sonar

There is increasing concern about the potential effects of noise pollution on marine life in the world’s oceans. For marine mammals, anthropogenic sounds may cause behavioral disruption, and this can be quantified using a risk function that relates sound exposure to a measured behavioral response. Beaked whales are a taxon of deep diving whales that may be particularly susceptible to naval sonar as the species has been associated with sonar-related mass stranding events. Here we derive the first empirical risk function for Blainville’s beaked whales (Mesoplodon densirostris) by combining in situ data from passive acoustic monitoring of animal vocalizations and navy sonar operations with precise ship tracks and sound field modeling. The hydrophone array at the Atlantic Undersea Test and Evaluation Center, Bahamas, was used to locate vocalizing groups of Blainville’s beaked whales and identify sonar transmissions before, during, and after Mid-Frequency Active (MFA) sonar operations. Sonar transmission times and source levels were combined with ship tracks using a sound propagation model to estimate the received level (RL) at each hydrophone. A generalized additive model was fitted to data to model the presence or absence of the start of foraging dives in 30-minute periods as a function of the corresponding sonar RL at the hydrophone closest to the center of each group. This model was then used to construct a risk function that can be used to estimate the probability of a behavioral change (cessation of foraging) the individual members of a Blainville’s beaked whale population might experience as a function of sonar RL. The function predicts a 0.5 probability of disturbance at a RL of 150dBrms re µPa (CI: 144 to 155) This is 15dB lower than the level used historically by the US Navy in their risk assessments but 10 dB higher than the current 140 dB step-function.
Maternal and Neonatal Levels of Perfluoroalkyl Substances in Relation to Gestational Weight Gain

Perfluoroalkyl substances (PFASs) are ubiquitous, persistent pollutants widely used in the production of common household and consumer goods. There is a limited body of literature suggesting that these chemicals may alter metabolic pathways and growth trajectories. The relationship between prenatal exposures to these chemicals and gestational weight gain (GWG) has received limited attention. One objective was to analyze the associations among maternal plasma levels of three common perfluoroalkyl substances (perfluorooctanoate (PFOA), perfluorooctanesulfonate (PFOS), perfluorohexanesulfanoate (PFHxS)) and GWG. Additionally, we explored whether GWG was associated with cord blood PFAS levels. This study utilized data collected in the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, a trans-Canada cohort study of 2001 pregnant women. Our analysis quantified associations between (1) maternal PFAS concentrations and GWG and (2) GWG and cord blood PFAS concentrations. Maternal PFOS concentrations were positively associated with GWG (β = 0.39 95% CI: 0.02, 0.75). Interquartile increases in GWG were significantly associated with elevated cord blood PFOA (OR = 1.33; 95% CI: 1.13 to 1.56) and PFOS (OR = 1.20; 95% CI: 1.03 to 1.40) concentrations. No statistically significant associations were observed between GWG and either measure of PFHxS. These findings warrant elucidation of the potential underlying mechanisms.
New optical fibres for high-capacity optical communications

Researchers are within a factor of 2 or so from realizing the maximum practical transmission capacity of conventional single-mode fibre transmission technology. It is therefore timely to consider new technological approaches offering the potential for more cost-effective scaling of network capacity than simply installing more and more conventional single-mode systems in parallel. In this paper, I review physical layer options that can be considered to address this requirement including the potential for reduction in both fibre loss and nonlinearity for single-mode fibres, the development of ultra-broadband fibre amplifiers and finally the use of space division multiplexing.
Disruption of PML Nuclear Bodies Is Mediated by ORF61 SUMO-Interacting Motifs and Required for Varicella-Zoster Virus Pathogenesis in Skin

Promyelocytic leukemia protein (PML) has antiviral functions and many viruses encode gene products that disrupt PML nuclear bodies (PML NBs). However, evidence of the relevance of PML NB modification for viral pathogenesis is limited and little is known about viral gene functions required for PML NB disruption in infected cells in vivo. Varicella-zoster virus (VZV) is a human alphaherpesvirus that causes cutaneous lesions during primary and recurrent infection. Here we show that VZV disrupts PML NBs in infected cells in human skin xenografts in SCID mice and that the disruption is achieved by open reading frame 61 (ORF61) protein via its SUMO-interacting motifs (SIMs). Three conserved SIMs mediated ORF61 binding to SUMO1 and were required for ORF61 association with and disruption of PML NBs. Mutation of the ORF61 SIMs in the VZV genome showed that these motifs were necessary for PML NB dispersal in VZV-infected cells in vitro. In vivo, PML NBs were highly abundant, especially in basal layer cells of uninfected skin, whereas their frequency was significantly decreased in VZV-infected cells. In contrast, mutation of the ORF61 SIMs reduced ORF61 association with PML NBs, most PML NBs remained intact and importantly, viral replication in skin was severely impaired. The ORF61 SIM mutant virus failed to cause the typical VZV lesions that penetrate across the basement membrane into the dermis and viral spread in the epidermis was limited. These experiments indicate that VZV pathogenesis in skin depends upon the ORF61-mediated disruption of PML NBs and that the ORF61 SUMO-binding function is necessary for this effect. More broadly, our study elucidates the importance of PML NBs for the innate control of a viral pathogen during infection of differentiated cells within their tissue microenvironment in vivo and the requirement for a viral protein with SUMO-binding capacity to counteract this intrinsic barrier.
Ungrounded kinesthetic pen for haptic interaction with virtual environments

We proposed a pen-shaped handheld haptic display that provides kinesthetic sensations to the fingers of a user without the use of mechanical linkages. The user's movements are not restricted since the device does not have mechanical linkages, and the user can enjoy haptic interactions with virtual environments. In order to downsize the device, we designed our device on the basis of a hypothesis that kinesthetic sensations on the user's fingers alone are sufficient to represent the sensations of touch. We implemented a prototype device and performed an experiment to confirm the representational ability of our device. We also developed a prototype haptic augmented reality system, using which the user can see and touch a computer graphics object.
Conventional vs. alternative energy sources overview. Part II. European strategies

The production and use of energy places a wide range of pressures on the environment and on public health, some of which have been decreasing. Enhancing renewable energy is another key factor for reaching the dual goals of security of supply and reduction of emissions of greenhouse gases and air pollution emissions. In addition, a more mature market for renewable energy technologies is expected to bring about a number of social and economic benefits, including regional and local development opportunities, export opportunities, social cohesion and employment. The paper is divided into 3 parts. Within the 1st part the energy-related environmental issues are discussed. The 2nd part is focusing on analyzing the trends related to renewable energy sources, using data collected from Member States and reported by the European Environment Agency and energy statistics for the period 1990–2005 covering the whole European Union. The 3rd part presents the renewable energy sources in Romania and the current situation in the country.
Stochastic firing rate models

We review a recent approach to the mean-field limits in neural networks that takes into account the stochastic nature of input current and the uncertainty in synaptic coupling. This approach was proved to be a rigorous limit of the network equations in a general setting, and we express here the results in a more customary and simpler framework. We propose a heuristic argument to derive these equations providing a more intuitive understanding of their origin. These equations are characterized by a strong coupling between the different moments of the solutions. We analyse the equations, present an algorithm to simulate the solutions of these mean-field equations, and investigate numerically the equations. In particular, we build a bridge between these equations and Sompolinsky and collaborators approach (1988, 1990), and show how the coupling between the mean and the covariance function deviates from customary approaches.
Continuous Gesture Recognition System Using Improved HMM Algorithm Based on 2D and 3D Space

In this paper, we explain a study on natural user interface (NUI) in human gesture recognition using RGB color information and depth information by Kinect camera from Microsoft Corporation. To achieve the goal, hand tracking and gesture recognition have no major dependencies of the work environment, lighting or users’ skin color, libraries of particular use for natural interaction and Kinect device, which serves to provide RGB images of the environment and the depth map of the scene were used. An improved Camshift tracking algorithm combined with depth information is used to tracking hand motion, and then an associative method of HMM and FNN is propose for gesture recognition step. The experimental results show out its good performance and it has higher stability and accuracy as well.
FUZZY PARTIAL ORDER RELATIONS AND FUZZY LATTICES

We characterize a fuzzy partial order relation using its level set, find sufficient conditions for the image of a fuzzy partial order relation to be a fuzzy partial order relation, and find sufficient conditions for the inverse image of a fuzzy partial order relation to be a fuzzy partial order relation. Also we define a fuzzy lattice as fuzzy relations, characterize a fuzzy lattice using its level set, show that a fuzzy totally ordered set is a distributive fuzzy lattice, and show that the direct product of two fuzzy lattices is a fuzzy lattice.
Candidates for giant lobes projecting from the LBV stars P Cygni and R 143

Received ; accepted Abstract. Deep, wide-field, continuum-subtracted, images in the light of the H� + (N ii) 6548 & 6584 u and (O iii)5007 u nebular emission lines have been obtained of the environment of the Luminous Blue Variable (LBV) star P Cygni. A previously discovered, receding, nebulous filament along PA 50 ◦ has now been shown to extend up to 12 ' from this star. Furthermore, in the light of (O iii)5007 u a southern counterpart is discovered as well as irregular filaments on the opposite side of P Cygni. Line profiles from this nebulous complex indicate that this extended nebulosity is similar to that associated with middle-aged supernova remnants. However, there are several indications that it has originated in P Cygni and is not just a chance superposition along the same sight-line. This possibility is explored here and comparison is made with a new image of the LBV star R 143 in the LMC from which similar filaments appear to project. The dynamical age of the P Cygni giant lobe of � 5×10 4 yr is consistent with both the predicted and observed durations of the LBV phases of 50 M⊙ stars after they have left the main sequence. Its irregular shape may have been determined by the cavity formed in the ambient gas by the energetic wind of the star, and shaped by a dense torus, when on the main sequence. The proper motion and radial velocity of P Cygni, with respect to its local environment, could explain the observed angular and kinematical shifts of the star compared with the giant lobe.
Overexpression of Pituitary Adenylate Cyclase-Activating Polypeptide in Islets Inhibits Hyperinsulinemia and Islet Hyperplasia in Agouti Yellow Mice

Pituitary adenylate cyclase-activating polypeptide (PACAP) is an intraislet neuropeptide and shares insulinotropic and insulin-sensitizing properties with glucagon-like peptide-1 (GLP-1); however, the pathophysiological significance of PACAP in diabetes remains largely unknown. To assess this, we crossed our recently developed transgenic mice overexpressing PACAP in pancreatic β-cells (Tg/+), with lethal yellow agouti (KKAy) mice (Ay/+), a genetic model for obesity-diabetes, and examined the metabolic and morphological phenotypes of F1 animals. Tg/+ mice with the Ay allele (Tg/+:Ay/+) developed maturity-onset obesity and diabetes associated with hyperglycemia, hyperlipidemia, and hyperphagia, similar to those of Ay/+ mice, but hyperinsulinemia was significantly ameliorated in Tg/+:Ay/+ mice. Although Ay/+ mice exhibited a marked increase in islet mass resulting from hyperplasia and hypertrophy, this increase was significantly attenuated in Tg/+:Ay/+ mice. Size frequency distribution analysis revealed that the very large islets comprising one-fourth of islets of Ay/+ mice were selectively reduced in Tg/+:Ay/+ mice. Because functional defects have been demonstrated in the large islets of obese animal models, together these findings suggest that PACAP regulates hyperinsulinemia and the abnormal increase in islet mass that occurs during the diabetic process.
Oral Health Status and Treatment Needs among Pregnant Women of Raichur District, India: A Population Based Cross-Sectional Study

Background and Objectives. Pregnancy can be a risk factor for dental diseases as oral tissues are liable to changes due to hormonal variations. The aim of the study was to assess the oral health status and treatment needs among pregnant women of Raichur district, Karnataka, India. Methods. Cross-sectional data was collected from 300 primigravidae from all the 5 taluks of Raichur district visiting the respective community health centre at taluk headquarters. A specially designed questionnaire was used to assess the demographic variables and oral hygiene practices. A clinical examination was done according to WHO (World Health Organization) criteria 1997 and recorded using WHO Oral Health Assessment Form. Results. The mean age of the pregnant women in the study was 21.8 (2.12) years. The prevalence of caries and periodontal diseases was 62.7% and 95%, respectively. The mean DT, MT, FT, and DMFT were 2.06 (2.5), 0.03 (0.17), 0.04 (0.27), and 2.13 (2.54), respectively. The mean OHI-S was 2.87 (1.27). Chi-square test showed that CPI scores increased with the trimester of pregnancy. Conclusion. The present study demonstrates poor oral hygiene and high prevalence of periodontal diseases, as well as a large proportion of unmet dental treatment needs among pregnant women of Raichur district, India.
Practical Aspects of Query Rewriting for OWL 2

A process for the simultaneous replacement of a first catalyst by a second catalyst which first catalyst is circulating as a moving bed of solid particles in a hydrocarbon treating unit, which unit comprises at least one processing reactor. The first catalyst is withdrawn downstream of the reactor, or of each reactor, in the direction of catalyst circulation. The second catalyst is simultaneously injected upstream of the reactor or of each reactor. The bulk density of the material withdrawn downstream of the reactor, or of each reactor, is measured continuously. The withdrawal of the first catalyst and the injection of the second catalyst into the reactor concerned are interrupted when the bulk density so measured is equal to that of the second catalyst.
Development and validation of the predrinking motives questionnaire

Elaborating on instruments for U.S. university students, we developed and validated the predrinking (drinking before going out) motives questionnaire (PMQ) for general populations of young adults. In popular nightlife areas in Switzerland, 316 predrinkers aged 16-25 (48% women) were recruited. Focus group interviews and exploratory and confirmatory factor analyses yielded a three-factor measure, with a structure that was invariant across linguistic regions, gender, age, and student status. "Fun/intoxication" motives were associated with predrinking but "conviviality" and "facilitation" motives were not. Men scored higher on "facilitation" than women and those from the French-speaking region scored higher on "conviviality" than German-speaking participants. Although yet to be replicated in other countries, the PMQ appears to be an appropriate general measure of predrinking motives.
Fourth Estate or Mouthpiece? A Formal Model of Media, Protest, and Government Repression

New media dramatically increase citizens' access to information and decrease governments' ability to control the flow of communication. Although human rights nongovernmental organizations have advocated that access to independent news media will improve government respect for human rights, recent empirical studies have shown this is not always the case. We posit that media independence and the presence or absence of democratic characteristics, in particular political competition, have substantial effects on government repression because these factors determine the degree to which the government is vulnerable to public pressures. The model developed here includes three equations that encompass the impact of interaction between and among the news media, citizens, and government. The first equation specifies the influences on the news media's decision whether or not to perform a “watchdog” role regarding government repression. The second equation represents public reaction to the news media's coverage of government repression (i.e., protest). Here access to news media via traditional and new media is an important factor. The third equation represents government repression. Solutions to the system of equations are derived for four scenarios (a) Democracy and media independence are both present, (b) democracy is present but media independence is absent, (c) democracy is absent (autocracy) and media independence is present, and (d) democracy is absent (autocracy) and media independence is absent. We then consider interesting properties of the anticipated behavior from the government, media, and general public through case illustrations for the Netherlands and Myanmar/Burma. [Supplementary material is available for this article. Go to the publisher's online edition of Political Communication for the following free supplemental resource: two additional case illustrations (Tanzania and Brazil). ]
Optimal Power Allocation and User Scheduling in Multicell Networks: Base Station Cooperation Using a Game-Theoretic Approach

This paper proposes a novel base station (BS) coordination approach for intercell interference mitigation in the orthogonal frequency-division multiple access based cellular networks. Specifically, we first propose a new performance metric for evaluating end user's quality of experience (QoE), which jointly considers spectrum efficiency, user fairness, and service satisfaction. Interference graph is applied here to capture and analyze the interactions between BSs. Then, a QoE-oriented resource allocation problem is formulated among BSs as a local cooperation game, where BSs are encouraged to cooperate with their peer nodes in the adjacent cells in user scheduling and power allocation. The existence of the joint-strategy Nash equilibrium (NE) has been proved, in which no BS player would unilaterally change its own strategy in user scheduling or power allocation. Furthermore, the NE in the formulated game is proved to lead to the global optimality of the network utility. Accordingly, we design an iterative searching algorithm to obtain the global optimum (i.e., the best NE) with an arbitrarily high probability in a decentralized manner, in which only local information exchange is needed. Theoretical analysis and simulation results both validate the convergence and optimality of the proposed algorithm with fairness improvement.
Realization Theory for Discrete-Time Piecewise-Affine Hybrid Systems

The paper investigates the realization problem for piecewise-affine discrete-time hybrid systems. A piecewise-affine discrete-time hybrid system is a discrete-time system such that the state-transition and readout maps are piecewise-affine maps. We will restrict our attention to autonomous systems and we will study the following realization problem. For a specified output trajectory, find a piecewise-affine hybrid system which realizes this output trajectory. We will show that the realization problem for discrete-time piecewise-affine hybrid systems is equivalent to the realization problem for discrete-time switched linear systems. We will give necessary and sufficient conditions for existence of a realization by a discrete-time piecewise-affine and a discrete-time switched linear system. We will also present a procedure for constructing a discrete-time linear switched system and a discrete-time piecewise-affine hybrid system realizing the specified output trajectory.