Miracle-dz/UniFAR-FTUs huggingface dataset:
Enteric-type adenocarcinoma of the lung harbouring a novel KRAS Q22K mutation with concomitant KRAS polysomy: a case report

This case describes a novel KRAS Q22K mutation with simultaneous KRAS polysomy in a patient with advanced, enteric-type, adenocarcinoma of the lung. Despite the administration of systemic chemotherapy, the disease underwent rapid progression and led to the patient’s death in a short period of time. Such an aggressive clinical course suggests that, in this specific case, KRAS dependency was the major genetic driver of poor prognosis. Direct deoxy ribonucleic acid (DNA) sequencing of the KRAS gene allows for the detection of novel KRAS mutations, and it might be advocated in patients with advanced non-small cell lung cancer in view of the emerging role of KRAS as a potential therapeutic target.
Microsecond exchange of internal water molecules in bacteriorhodopsin.

The proton-conducting pathway of bacteriorhodopsin (BR) contains at least nine internal water molecules that are thought to be key players in the proton translocation mechanism. Here, we report the results of a multinuclear (1H, 2H, 17O) magnetic relaxation dispersion (MRD) study with the primary goal of determining the rate of exchange of these internal water molecules with bulk water. This rate is of interest in current attempts to elucidate the molecular details of the proton translocation mechanism. The relevance of water exchange kinetics is underscored by recent crystallographic findings of substantial variations in the number and locations of internal water molecules during the photocycle. Moreover, internal water exchange is believed to be governed by conformational fluctuations in the protein and can therefore provide information about the thermal accessibility of functionally important conformational substates. The present 2H and 17O MRD data show that at least seven water molecules, or more if they are orientationally disordered, in BR have residence times (inverse exchange rate constant) in the range 0.1-10 micros at 277 K. At least five of these water molecules have residence times in the more restrictive range 0.1-0.5 micros. These results show that most or all of the deeply buried water molecules in BR exchange on a time-scale that is short compared to the rate-limiting step in the photocycle. The MRD measurements were performed on BR solubilized in micelles of octyl glucoside. From the MRD data, the rotational correlation time of detergent-solubilized BR was determined to 35 ns at 300 K, consistent with a monomeric protein in complex with about 150 detergent molecules. The solubilized protein was found to be stable in the dark for at least eight months at 277 K.
Cultural Literacy Assimilation: The Literacy Experiences of Children of Immigrants.

A dissertation submitted to The Graduate School of Education Rutgers, The State University of New Jersey In partial fulfillment of the requirements For the degree Doctor of Education Graduate Program in Literacy Education Approved by _______________________________ Erica Boling, Chair _______________________________ Lesley M. Morrow _______________________________ Jennifer Rowsell _______________________________ Tanja Sargent
The Impact of Railway Stations on Residential and Commercial Property Value: A Meta-analysis

Railway stations function as nodes in transport networks and places in an urban environment. They have accessibility and environmental impacts, which contribute to property value. The literature on the effects of railway stations on property value is mixed in its finding in respect to the impact magnitude and direction, ranging from a negative to an insignificant or a positive impact. This paper attempts to explain the variation in the findings by meta-analytical procedures. Generally the variations are attributed to the nature of data, particular spatial characteristics, temporal effects and methodology. Railway station proximity is addressed from two spatial considerations: a local station effect measuring the effect for properties with in 1/4 mile range and a global station effect measuring the effect of coming 250 m closer to the station. We find that the effect of railway stations on commercial property value mainly takes place at short distances. Commercial properties within 1/4 mile rang are 12.2% more expensive than residential properties. Where the price gap between the railway station zone and the rest is about 4.2% for the average residence, it is about 16.4% for the average commercial property. At longer distances the effect on residential property values dominate. We find that for every 250 m a residence is located closer to a station its price is 2.3% higher than commercial properties. Commuter railway stations have a consistently higher positive impact on the property value compared to light and heavy railway/Metro stations. The inclusion of other accessibility variables (such as highways) in the models reduces the level of reported railway station impact.
Comparative Study of Physical Fitness Components of Rural and Urban Female Students of Punjabi University, Patiala

Abstract In the present study, an attempt has been made to compare physical fitness components namely speed, strength, endurance, agility and flexibility between female students belonging to rural and urban set-ups. The study was carried out on 100 female students, 50 rural and 50 urban of Punjabi University, Patiala. The data was collected by use of measurements of height and weight as well as by application of tests like jumping, stepping, running, flexibility test, etc. The data was analyzed and compared with the help of statistical procedures in which arithmetic mean, standard deviation (S.D.), standard error of mean (SEM), t-test were employed. Rural female students were found to be superior in strength, endurance, speed and agility. Urban female students on the other hand, were found to be heavier and superior in tasks like flexibility.
INFLUENCE OF MOTOR FUNCTIONAL MAGNETIC RESONANCE IMAGING ON THE SURGICAL MANAGEMENT OF CHILDREN AND ADOLESCENTS WITH SYMPTOMATIC FOCAL EPILEPSY

OBJECTIVETo determine the clinical value of motor functional magnetic resonance imaging (fMRI) in the presurgical evaluation of a large group of children and adolescents with epilepsy caused by lesions close to the central sulcus. METHODSForty-three patients (19 males; mean age, 13 years) with lesional focal epilepsy underwent motor fMRI as part of a multidisciplinary standardized presurgical evaluation between 2000 and 2006. fMRI data were analyzed using statistical parametric mapping (SPM2) and screened for the presence of movement-related artifacts. The ways in which the results of motor fMRI influenced the decision-making process were reviewed. RESULTSThe success rate of motor fMRI was 93% and data were of high quality in 67.5% of the patients. Together with other clinical considerations, motor fMRI results contributed to the surgical management of 32 patients (74%). They helped 1) to determine the type of surgery in 23 patients (72%; 12 cases with and 11 cases without invasive functional mapping), 2) to indicate a reduced benefit-risk ratio with the consequence that surgery was not further considered in 5 patients (16%), and 3) to indicate that surgery was not an appropriate option because of the high risk of motor function deficit in 4 patients (12%). CONCLUSIONMotor fMRI can be performed with a high degree of success and good data quality in this population of patients. It has an important additive role in the discussion of the feasibility of resective surgery contributing to the decision-making process for children with epilepsy caused by brain lesions close to the central sulcus.
Sex and Profession as Determinants of Field Dependence

This study explored whether consistently found sex differences in field-dependence, showing males more field independent than females, would persist when members of both sex groups have high spatial ability. No such differences were found between 16 male and 11 female Design and Architecture students who took the Group Embedded Figures Test. Apparently biological sex alone does not determine field-dependence; this study calls for examination of the relationship between spatial ability and field dependence.
Differential Expression of Alternative Oxidase Genes in Maize Mitochondrial Mutants Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.005603.

We have examined the expression of three alternative oxidase (aox) genes in two types of maize mitochondrial mutants. Nonchromosomal stripe (NCS) mutants carry mitochondrial DNA deletions that affect subunits of respiratory complexes and show constitutively defective growth. Cytoplasmic male-sterile (CMS) mutants have mitochondrial DNA rearrangements, but they are impaired for mitochondrial function only during anther development. In contrast to normal plants, which have very low levels of AOX, NCS mutants exhibit high expression of aox genes in all nonphotosynthetic tissues tested. The expression pattern is specific for each type of mitochondrial lesion: the NADH dehydrogenase–defective NCS2 mutant has high expression of aox2, whereas the cytochrome oxidase–defective NCS6 mutant predominantly expresses aox3. Similarly, aox2 and aox3 can be induced differentially in normal maize seedlings by specific inhibitors of these two respiratory complexes. Translation-defective NCS4 plants show induction of both aox2 and aox3. AOX2 and AOX3 proteins differ in their ability to be regulated by reversible dimerization. CMS mutants show relatively high levels of aox2 mRNAs in young tassels but none in ear shoots. Significant expression of aox1 is detected only in NCS and CMS tassels. The induction pattern of maize aox genes could serve as a selective marker for diverse mitochondrial defects.
Spontaneous Activity of Auditory-Nerve Fibers: Insights into Stochastic Processes at Ribbon Synapses

In several sensory systems, the conversion of the representation of stimuli from graded membrane potentials into stochastic spike trains is performed by ribbon synapses. In the mammalian auditory system, the spiking characteristics of the vast majority of primary afferent auditory-nerve (AN) fibers are determined primarily by a single ribbon synapse in a single inner hair cell (IHC), and thus provide a unique window into the operation of the synapse. Here, we examine the distributions of interspike intervals (ISIs) of cat AN fibers under conditions when the IHC membrane potential can be considered constant and the processes generating AN fiber activity can be considered stationary, namely in the absence of auditory stimulation. Such spontaneous activity is commonly thought to result from an excitatory Poisson point process modified by the refractory properties of the fiber, but here we show that this cannot be the case. Rather, the ISI distributions are one to two orders of magnitude better and very accurately described as a result of a homogeneous stochastic process of excitation (transmitter release events) in which the distribution of interevent times is a mixture of an exponential and a gamma distribution with shape factor 2, both with the same scale parameter. Whereas the scale parameter varies across fibers, the proportions of exponentially and gamma distributed intervals in the mixture, and the refractory properties, can be considered constant. This suggests that all of the ribbon synapses operate in a similar manner, possibly just at different rates. Our findings also constitute an essential step toward a better understanding of the spike-train representation of time-varying stimuli initiated at this synapse, and thus of the fundamentals of temporal coding in the auditory pathway.
Sertindole in the Management of Schizophrenia

Nowadays, new schizophrenia treatments are more ambitious than ever, aiming not only to improve psychotic symptoms, but also quality of life and social reinsertion. Our objective is to briefly but critically review the diagnosis of schizophrenia, the atypical antipsychotics sertindole's pharmacology, safety and status, and mainly evaluate the effects of sertindole compared with other second generation antipsychotics for people with schizophrenia and schizophrenia-like psychosis. In vitro studies showed that sertindole exerts a potent antagonism at serotonin 5-HT2A, 5-HT2C, dopamine D2, and αl adrenergic receptors. Sertindole offers an alternative treatment option for refractory patients given its good EPS profile, favorable metabolic profile, and comparable efficacy to risperidone. Due to cardiovascular safety concerns, sertindole is available as a second-line choice for patients intolerant to other antipsychotic agents. Further clinical studies, mainly comparisons with other second-generation antipsychotic agents, are needed to define the role of sertindole in the treatment of schizophrenia.
The far-right, immigrants, and the prospects of democracy satisfaction in Europe

This paper examines the consequences of the far-right in shaping foreign-born immigrants’ satisfaction with the way democracy works in their host country. It posits that while electorally successful far-right parties undermine democracy satisfaction, the magnitude of this effect is not uniform across all first-generation immigrants. Instead, it depends on newcomers’ citizenship status in their adopted homeland. The analyses using individual-level data collected as part of the five-round European Social Survey (ESS) 2002–2012 in 16 West European democracies reveal that the electoral strength of far-right parties in a form of vote and seat shares won in national elections is indeed powerfully linked to democracy satisfaction among foreign-born individuals. However, this relationship is limited to foreign-born non-citizens, as we have no evidence that far-right parties influence democracy attitudes among foreign-born individuals who have acquired citizenship in their adopted homeland.
The TRIBECA study: (TRI)fecta (B)ioprosthesis (E)valuation versus (C)arpentier Magna-Ease in (A)ortic position.

OBJECTIVE To determine whether the Trifecta bioprosthetic aortic valve produces postoperative haemodynamic results comparable with or better than those of the Magna Ease aortic valve bioprosthesis. METHODS We retrospectively reviewed the medical records of patients who had undergone aortic valve replacement with Trifecta or Magna Ease prostheses at eight European institutions between January 2011 and May 2013, and analysed early postoperative haemodynamic performance by means of echocardiography. RESULTS A total of 791 patients underwent aortic valve replacement (469 Magna Ease, 322 Trifecta). Haemodynamic variables were evaluated on discharge and during the follow-up (minimum 6 months, maximum 12 months). The mean gradient and the indexed effective orifice area (IEOA) were as follows: 10 mmHg [interquartile range (IQR): 8-13] and 1.10 cm(2)/m(2) (IQR: 0.95-1.27) for Trifecta; 16 mmHg (IQR: 11-22) and 0.96 cm(2)/m(2) (IQR: 0.77-1.13) for Magna Ease (P < 0.001). These significant differences were maintained across all valve sizes. Similar statistically significant differences were found when patients were matched and/or stratified for preoperative characteristics: body-surface area, ejection fraction, mean gradients and valve size. Severe prosthesis-patient mismatch (IEOA: <0.65 cm(2)/m(2)) was detected in 2 patients (0.6%) with Trifecta and 40 patients (8.5%) with Magna Ease (P < 0.001). CONCLUSIONS The haemodynamic performance of the Trifecta bioprosthesis was superior to that of the Magna Ease valve across all conventional prosthesis sizes, with almost no incidence of severe patient-prosthesis mismatch. The long-term follow-up is needed to determine whether these significant haemodynamic differences will persist, and influence clinical outcomes.
Are the Dimensions Underlying Aesthetic and Affective Judgment the Same?

To investigate whether aesthetic and affective judgment are similar, ninety-six subjects rated twenty-four art pictures varying in theme and date of creation as well as twenty-three emotion inducing slides (IAPS) representing different emotional qualities on nine bipolar 8-point scales, e.g., warm-cold, meaningful-not meaningful. Factor analyses performed separately for each picture set revealed two basic dimensions, named cognitive and emotional factors, explaining about 60 percent of the variance. In the case of artworks, the dominant factor was constituted by cognitive scales (meaningful, interesting, simple); regarding the affective slides, the main factor was constituted by emotional scales (warm, emotional, arousing). ANOVAs confirmed the expected differences between themes and date of creation for the art picture as well as the differences between emotional qualities of the IAPS for both, the cognitive and the emotional factor. Proportion of variance of the ratings explained by gender, age, and education was low. Overall, results suggest that looking at art objects is a predominantly cognitive process requiring understanding whereas looking at emotional pictures evokes feelings with cognitive processes being only marginally involved.
Multiple CMT source analysis of the 2004 Sumatra earthquake

While it is agreed that the great Sumatra earthquake of December 26, 2004 was among the largest earthquakes of the past century, there has been disagreement on how large it was, which part of the fault ruptured, and how the rupture took place. We present a centroid‐moment‐tensor (CMT) analysis of the earthquake in which multiple point sources are used in the inversion to mimic a propagating slip pulse. The final model consists of five point sources, with the southernmost sources accounting for the majority of the moment release. The presumed fault planes of the southern sources strike northwest, while those in the north strike northeast, consistent with the geometry of the subduction trench. Slip on the fault is found to be more oblique in the north than in the south. The inversion with five sources leads to a moment magnitude for the Sumatra earthquake of MW = 9.3, consistent with estimates from long‐period normal‐mode amplitudes.
A real time signal processing technique for MIDI generation

This paper presents a new hardware interface using a microcontroller which processes audio music signals to standard MIDI data. A technique for processing music signals by extracting note parameters from music signals is described. An algorithm to convert the voice samples for real time processing without complex calculations is proposed. A high frequency microcontroller as the main processor is deployed to execute the outlined algorithm. The MIDI data generated is transmitted using the EIA-232 protocol. The analyses of data generated show the feasibility of using microcontrollers for real time MIDI generation hardware interface.
How many species of cichlid fishes are there in African lakes?

The endemic cichlid fishes of Lakes Malawi, Tanganyika and Victoria are textbook examples of explosive speciation and adaptive radiation, and their study promises to yield important insights into these processes. Accurate estimates of species richness of lineages in these lakes, and elsewhere, will be a necessary prerequisite for a thorough comparative analysis of the intrinsic and extrinsic factors influencing rates of diversification. This review presents recent findings on the discoveries of new species and species flocks and critically appraises the relevant evidence on species richness from recent studies of polymorphism and assortative mating, generally using behavioural and molecular methods. Within the haplochromines, the most species‐rich lineage, there are few reported cases of postzygotic isolation, and these are generally among allopatric taxa that are likely to have diverged a relatively long time in the past. However, many taxa, including many which occur sympatrically and do not interbreed in nature, produce viable, fertile hybrids. Prezygotic barriers are more important, and persist in laboratory conditions in which environmental factors have been controlled, indicating the primary importance of direct mate preferences. Studies to date indicate that estimates of alpha (within‐site) diversity appear to be robust. Although within‐species colour polymorphisms are common, these have been taken into account in previous estimates of species richness. However, overall estimates of species richness in Lakes Malawi and Victoria are heavily dependent on the assignation of species status to allopatric populations differing in male colour. Appropriate methods for testing the specific status of allopatric cichlid taxa are reviewed and preliminary results presented.
The two-stage concept with temporary subcutaneous implantation of a vacuum sealing system: an alternative surgical approach in infected partial abdominal defects after lapratomy or abdominoplasty.

BACKGROUND Infected abdominal defects after laparatomy or abdominoplasty may present serious complications. The management of a progressive infection in the abdominal region with partial necrosis -without peritoneal irritation - is treated variously. Multiple revisions due to re-infection or seroma are often necessary. The different surgical treatment options almost always necessitate an extended immobilisation and hospitalisation of the patient. PATIENTS AND METHODS In five patients with infected partial abdominal defects after abdominoplasty (n = 3) or laparatomy (n = 2) successful management of infection was achieved in a two stages with temporary subcutaneous implantation of a polyurethane foam, combined with a vacuum assisted wound closure device, followed by secondary wound closure. In the first step a debridement, subcutaneous implantation of the foam, combined with intermittent subathmospheric pressure through a V.A. C. device was performed. In the second step an explantation of the foam, re-debridement and secondary wound closure was possible over 2 - 4 drains. RESULTS In all patients - after a temporary immobilisation of 5 days, and systemic antibiotic administration - wound healing was achieved. In one diabetic patient another single revision was necessary, because of the necrosis of a distal wound edge. The mean hospitalisation after application of these procedures was 15 days (12 - 19). CONCLUSIONS The surgical treatment of infected partial abdominal defects after laparatomy or abdominoplasty - performed in a two-stage procedure with temporary subcutaneous implantation of a V.A. C. -system, and secondary wound closure, offers a high level of safety, and presents an useful alternative tool in the difficult management of these patients.
Monotonically Computable Real Numbers

A real number x is called semi-computable if it is a limit of an increasing or decreasing computable sequence (x n ), n∈ℕ of ratio­nal numbers. In this case, a later member of the sequence is always a better approximation to x in the sense that |x − x n | ≥ |x − x m |, if n ≤ m. As a natural generalization, we call a real number x k-monotone computable (k-mc, for short), for any real number k >0,, if there is a computable sequence (xn),n∈ℕ of rational numbers which converges to x k-monotonically in the sense that k · |x − x n | ≥ |x − x m | for any n ≤ m and x is monotonically computable (mc, for short) if it is k-mc for some k >0. Various properties of k-mc real numbers are discussed in this pa­per. Among others we show that a real number is computable if it is k-mc for some k <1; the 1-mc real numbers are just the semi-computable real numbers and the set of all mc real numbers is contained properly in the set of weakly computable real numbers, where x is weakly computable if there are semi-computable real numbers y, z such that x = y + z. Furthermore, we show also an infinite hierarchy of mc real numbers.