Miracle-dz/UniFAR-FTUs huggingface dataset:
Tunable elliptic filters using multioutput current controlled conveyors

The circuit topologies are proposed for realizing the continuous time current-mode ladder filter of any order. The derived technique is based on the attractive features of the leapfrog simulation implementing using only multioutput second generation current controlled conveyor (MCCCII) and grounded capacitors that lead to simple structure, easy to design and suitable for IC fabrication. An example of the third-order elliptic low-pass filter which retains a minimum requirement of passive and active elements, as well as, possess the advantage of electronically tunable in cut-off frequency has been introduced. Moreover, this method can also be implemented by adding floating capacitors to the relative all-pole filter. Simulation results are provided to compare against the prototype passive RLC filter.
IgG4-related Disease - A Systemic Disease that Deserves Attention Regardless of One's Subspecialty

IgG4-related disease (IgG4-RD) is an inflammatory condition characterized by a high serum IgG4 concentration and the abundant infiltration of lymphocytes and IgG4-positive plasma cells in the tissue, as well as spatial (diverse clinical manifestations) and temporal (the possibility of recurrence) multiplicities. Since the initial documentation of IgG4-related disease in patients with autoimmune pancreatitis in 2001, a growing body of evidence has been accumulating to suggest that various-virtually all-organs can be affected by IgG4-RD. In general, steroid therapy is effective and is considered to be the first-line treatment for IgG4-RD. The precise mechanism underlying this systemic disorder has remained unknown. Considering that IgG4-RD was specified as being an intractable disease in 2015, further studies are needed to clarify whether IgG4-RD is indeed a distinct disease entity or a complex of disorders of different etiologies and clinical conditions.
A new proposal of rotor position estimation in IPM motor drives based on PWM current harmonics

The paper investigates successfully the possibility of extract rotor position information of Interior Permanent Motors from PWM current harmonic contents. To this aim, a general description of PWM voltage harmonics is at first given. Current harmonics are then derived assuming an anisotropic rotor. It is proved that rotor position information can be derived if single edge PWM is adopted. A speed and position estimation scheme is illustrated and the new rotor position estimation technique is then validated by simulations.
Transgenic ablation of doublecortin-expressing cells suppresses adult neurogenesis and worsens stroke outcome in mice

Injury stimulates neurogenesis in the adult brain, but the role of injury-induced neurogenesis in brain repair and recovery is uncertain. One strategy for investigating this issue is to ablate neuronal precursors and thereby prevent neurogenesis, but this is difficult to achieve in a specific fashion. We produced transgenic mice that express herpes simplex virus thymidine kinase (TK) under control of the promoter for doublecortin (Dcx), a microtubule-associated protein expressed in newborn and migrating neurons. Treatment for 14 days with the antiviral drug ganciclovir (GCV) depleted Dcx-expressing and BrdU-labeled cells from the rostral subventricular zone and dentate gyrus, and abolished neurogenesis and associated neuromigration induced by focal cerebral ischemia. GCV treatment of Dcx-TK transgenic, but not WT, mice also increased infarct size and exacerbated postischemic sensorimotor behavioral deficits measured by rotarod, limb placing, and elevated body swing tests. These findings provide evidence that injury-induced neurogenesis contributes to stroke outcome and might therefore be a target for stroke therapy.
Le dispositif d'évaluation de l'action IDEFI 7 : création de sections technologiques Identifier et maitriser les enjeux sociaux de l'évaluation

L’evaluation de l’action 7 IDEFI, ”Creation de sections technologiques” integre dans son dispositif la prise en compte des enjeux sociaux de l’innovation. Pour depasser les logiques fonctionnaliste et instrumentale generalement retenues, l’evaluation developpe une demarche centree sur les competences sociales et le developpement personnel des etudiants. Cette communication expose la methodologie generale de cette demarche, son operationnalisation et le cadre theorique qui la soutient.
Emotional strategizing in service innovation

Purpose – The purpose of this paper is to shed light on an aspect of service innovation processes that has remained fairly hidden so far, namely, the role of emotions. Design/methodology/approach – The authors use the strategizing approach from strategy research, which focusses on detailed processes, practices, and discourse, to understand the influence of emotions on service innovation processes. The empirical data stem from a longitudinal ethnographic study of a service innovation process. Findings – In the investigated case, the dominant emotion of anxiety is revealed. The authors focus on this emotion in order to explore how it affects the innovation process itself and the outcome. The authors identify five emotion-driven practices that form elements of what the authors label emotional strategizing. Practical implications – Emotion seems to give energy and direction to the service innovation process. This is both positive and challenging for top-level managers. Originality/value – The authors reveal a.
15–21‐year Results of the Charnley Low‐friction Arthroplasty

Ninety-three patients had had 116 Charnley low-friction arthroplasties (LFA) 15 to 21 years (mean, 16.6 years) previously. Their mean age at surgery was 53 years (range, 20–71 years). Fifty-two had osteoarthritis and 19 had rheumatoid arthritis. At follow-up, 85.3% were completely pain-free and 11.2% had occasional discomfort. Seventy-eight percent had near full or full range of movements. Acetabular bone-cement junction was unchanged in 32, and 20 had nonprogressive demarcation of the outer one third measuring less than 1 mm in width. In 36, socket demarcation was complete. Medial femoral cortex was unchanged in 56% and 44% showed loss of definition. Endosteal cavitation of the femur was present in 20.7%. Subsidence of the stem or the stem-cement complex was present in 29%. The diameter of the femoral cortex near the tip of the stem remained unaltered in 83.6%. The rate of socket wear was 0.096 mm/year, and there was a highly significant correlation between time and wear but no correlation between wear and patient's weight. Twenty-two and five-tenths percent of sockets migrated; this was statistically related to the depth of socket wear. The excellent clinical results of a relatively unsophisticated early surgical technique strongly supported the correct concept of the low-frictional torque. Improvements in the surgical technique and component design will further improve the long-term results.
Primed for Discovery: Atomic-Resolution Cryo-EM Structure of a Reovirus Entry Intermediate

A recently solved structure of the aquareovirus virion (Zhang, X; Jin, L.; Fang, Q; Hui, W.H.; Zhou Z.H. 3.3 Å Cryo-EM Structure of a Nonenveloped Virus Reveals a Priming Mechanism for Cell Entry. Cell 2010, 141, 472–482 [1]) provides new insights into the order of entry events, as well as confirming and refining several aspects of the entry mechanism, for aquareovirus and the related orthoreovirus. In particular, the structure provides evidence of a defined order for the progressive proteolytic cleavages of myristoylated penetration protein VP5 that prime the virion for membrane penetration. These observations reinforce the concept that, much like enveloped viruses, nonenveloped virions often undergo priming events that lead to a meta-stable state, preparing the virus for membrane penetration under the appropriate circumstances. In addition, this and other recent studies highlight the increasing power of electron cryomicroscopy to analyze large, geometrically regular structures, such as icosahedral viruses, at atomic resolution.
Reconstruction of sculpture from its profiles with unknown camera positions

Profiles of a sculpture provide rich information about its geometry, and can be used for shape recovery under known camera motion. By exploiting correspondences induced by epipolar tangents on the profiles, a successful solution to motion estimation from profiles has been developed in the special case of circular motion. The main drawbacks of using circular motion alone, namely the difficulty in adding new views and part of the object always being invisible, can be overcome by incorporating arbitrary general views of the object and registering its new profiles with the set of profiles resulting from the circular motion. We describe a complete and practical system for producing a three-dimensional (3D) model from uncalibrated images of an arbitrary object using its profiles alone. Experimental results on various objects are presented, demonstrating the quality of the reconstructions using the estimated motion.
Catheter Colonization and Abscess Formation Due to Staphylococcus epidermidis with Normal and Small-Colony-Variant Phenotype Is Mouse Strain Dependent

Coagulase-negative staphylococci (CoNS) form a thick, multilayered biofilm on foreign bodies and are a major cause of nosocomial implant-associated infections. Although foreign body infection models are well-established, limited in vivo data are available for CoNS with small-colony-variant (SCV) phenotype described as causative agents in implant-associated infections. Therefore, we investigated the impact of the Staphylococcus epidermidis phenotype on colonization of implanted PVC catheters and abscess formation in three different mouse strains. Following introduction of a catheter subcutaneously in each flank of 8- to 12-week-old inbred C57BL/6JCrl (B6J), outbred Crl:CD1(ICR) (CD-1), and inbred BALB/cAnNCrl (BALB/c) male mice, doses of S. epidermidis O-47 wild type, its hemB mutant with stable SCV phenotype, or its complemented mutant at concentrations of 106 to 109 colony forming units (CFUs) were gently spread onto each catheter. On day 7, mice were sacrificed and the size of the abscesses as well as bacterial colonization was determined. A total of 11,500 CFUs of the complemented mutant adhered to the catheter in BALB/c followed by 9,960 CFUs and 9,900 CFUs from S. epidermidis wild type in BALB/c and CD-1, respectively. SCV colonization was highest in CD-1 with 9,500 CFUs, whereas SCVs were not detected in B6J. The minimum dose that led to colonization or abscess formation in all mouse strains was 107 or 108 CFUs of the normal phenotype, respectively. A minimum dose of 108 or 109 CFU of the hemB mutant with stable SCV phenotype led to colonization only or abscess formation, respectively. The largest abscesses were detected in BALB/c inoculated with wild type bacteria or SCV (64 mm2 vs. 28 mm2). Our results indicate that colonization and abscess formation by different phenotypes of S. epidermidis in a foreign body infection model is most effective in inbred BALB/c followed by outbred CD-1 and inbred B6J mice.
SYNTHESIS AND PRELIMINARY PHARMACOLOGICAL EVALUATION OF NEW NAPROXEN ANALOGUES HAVING 1, 2, 4-TRIAZOLE-3-THIOL

Objective: The objective of this search was to synthesize a new naproxen analogues having a 1,2,4-triazole-3-thiol heterocyclic ring, and preliminary pharmacological assessment of the anti-inflammatory activity of the synthesized compounds. Methods: The synthesis of naproxen analogues that having 1,2,4-triazole-3-thiol heterocyclic ring occur through esterification of naproxen, and then its reaction with hydrazine hydrate, and carbon disulfide, finally different aromatic aldehydes reacted with triazole derivatives of naproxen containing amino group to produce schiff bases. Results: In vivo acute anti-inflammatory activity of the synthesize compounds (Va-Vd) was evaluated in rats using egg-white induced edema model of inflammation in a dose equivalent to (50 mg/kg) of naproxen. All tested compounds were produced a significant reduction in paw edema with respect to the effect of propylene glycol 50% v/v (control group). Compound Vd produced superior anti-inflammatory activity compared to naproxen. Conclusion: The results obtained in this work give evidence about the valid synthesis of 1,2,4 triazole-3-thiol derivatives of naproxen, which reacted with different aldehydes to yield several schiff bases. The incorporation of benzaldehyde possess para-electron donating group (para-hydroxyl benzaldehyde) will increase the anti-inflammatory activity of naproxen. Normal 0 false false false EN-US X-NONE AR-SA /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;}
Security analysis of logic encryption against the most effective side-channel attack: DPA

Logic encryption has recently gained interest as a countermeasure against IP piracy and reverse engineering attacks. A secret key is used to lock/encrypt an IC such that the IC will not be functional without being activated with the correct key. Existing attacks against logic encryption are of theoretical and/or algorithmic nature. In this paper, we evaluate for the first time the security of logic encryption against side-channel attacks. We present a differential power analysis attack against random and strong logic encryption techniques. The proposed attack is highly effective against random logic encryption, revealing more than 70% of the key bits correctly in 50% of the circuits. However, in the case of strong logic encryption, which exhibits an inherent DPA-resistance, the attack could reveal more than 50% of the key bits in only 25% of the circuits.
Influence of proton T1 on oxymetry using Overhauser enhanced magnetic resonance imaging

In Overhauser enhanced magnetic resonance imaging (OMRI) for in vivo measurement of oxygen partial pressure (pO2), a paramagnetic contrast agent is introduced to enhance the proton signal through dynamic nuclear polarization. A uniform proton T1 is generally assumed for the entire region of interest for the computation of pO2 using OMRI. It is demonstrated here, by both phantom and in vivo (mice) imaging, that such an assumption may cause erroneous estimate of pO2. A direct estimate of pixel‐wise T1 is hampered by the poor native MR intensities, owing to the very low Zeeman field (15–20 mT) in OMRI. To circumvent this problem, a simple method for the pixel‐wise mapping of proton T1 using the OMRI scanner is described. A proton T1 image of a slice through the center of an SCC tumor in a mouse clearly shows a range of T1 distribution (0.2∼1.6 s). Computation of pO2 images using pixel‐wise T1 values promises oximetry with minimal artifacts by OMRI. Magn Reson Med 54:213–217, 2005. Published 2005 Wiley‐Liss, Inc.
Writes that Fall in the Forest and Make no Sound: Semantics-Based Adaptive Data Consistency

Datastores today rely on distribution and replication to achieve improved performance and fault-tolerance. But the correctness of many applications depends on strong consistency properties -- something that can impose substantial overheads, since it requires coordinating the behavior of multiple nodes. This paper describes a new approach to achieving strong consistency in distributed systems while minimizing communication between nodes. The key insight is to allow the state of the system to be inconsistent during execution, as long as this inconsistency is bounded and does not affect transaction correctness. In contrast to previous work, our approach uses program analysis to extract semantic information about permissible levels of inconsistency and is fully automated. We then employ a novel homeostasis protocol to allow sites to operate independently, without communicating, as long as any inconsistency is governed by appropriate treaties between the nodes. We discuss mechanisms for optimizing treaties based on workload characteristics to minimize communication, as well as a prototype implementation and experiments that demonstrate the benefits of our approach on common transactional benchmarks.
Diversity and Antimicrobial Activities of Actinobacteria Isolated from Tropical Mangrove Sediments in Malaysia

The aim of this study was to isolate and identify Actinobacteria from Malaysia mangrove forest and screen them for production of antimicrobial secondary metabolites. Eighty-seven isolates were isolated from soil samples collected at 4 different sites. This is the first report to describe the isolation of Streptomyces, Mycobacterium, Leifsonia, Microbacterium, Sinomonas, Nocardia, Terrabacter, Streptacidiphilus, Micromonospora, Gordonia, and Nocardioides from mangrove in east coast of Malaysia. Of 87 isolates, at least 5 isolates are considered as putative novel taxa. Nine Streptomyces sp. isolates were producing potent antimicrobial secondary metabolites, indicating that Streptomyces isolates are providing high quality metabolites for drug discovery purposes. The discovery of a novel species, Streptomyces pluripotens sp. nov. MUSC 135T that produced potent secondary metabolites inhibiting the growth of MRSA, had provided promising metabolites for drug discovery research. The biosynthetic potential of 87 isolates was investigated by the detection of polyketide synthetase (PKS) and nonribosomal polyketide synthetase (NRPS) genes, the hallmarks of secondary metabolites production. Results showed that many isolates were positive for PKS-I (19.5%), PKS-II (42.5%), and NRPS (5.7%) genes, indicating that mangrove Actinobacteria have significant biosynthetic potential. Our results highlighted that mangrove environment represented a rich reservoir for isolation of Actinobacteria, which are potential sources for discovery of antimicrobial secondary metabolites.
Effects of the insertional and appositional forces of the canine diaphragm on the lower ribs

• Although the diaphragm causes a fall in pleural pressure, it expands the lower portion of the ribcage when it contracts. • This action is conventionally considered to be the result of two mechanisms, namely, the force applied by the muscle fibres on the ribs into which they insert (insertional force) and the transmission of abdominal pressure through the zone of apposition (appositional force). • In this study in anaesthetized dogs, we assessed the magnitude of the force exerted by the diaphragm on the lower ribs and the relative contributions of the insertional and appositional components. • The results show that, per unit pressure, the inspiratory effect of the diaphragmatic force on the lower ribs is equal to the expiratory effect of pleural pressure and that the insertional force contributes 60% of that inspiratory effect.
Pathogenesis of Chiari Malformation: A Morphometric Study of the Posterior Cranial Fossa

To investigate overcrowding in the posterior cranial fossa as the pathogenesis of adult type Chiari malformation, we morphometrically studied the brainstem and cerebellum within the posterior cranial fossa as well as the occipital bone while taking into consideration their embryological development. Compared with the control group, the Chiari group had a significantly larger “volume ratio” as PFBV/PFCV, the three occipital enchondral parts (the basiocciput, exocciput and supraocciput) were significantly smaller and the tentorium was much steeper. There was no significant difference in the posterior fossa brain volume or in the axial lengths of the hindbrain (the brainstem and cerebellum). These results suggest that in adult type Chiari malformation an underdeveloped occipital bone, possibly due to underdevelopment of the occipital somite originating from the paraxial mesoderm, induces overcrowding in the posterior cranial fossa which contains the normally developed hindbrain, and secondary the cerebellar tonsils herniate into the spinal canal.
The differentiation between neuroglia and connective tissue sheath in insect ganglia revisited: The neural lamella and perineurial sheath cells are absent in a mesodermless mutant of Drosophila

Two morphogenetic mutations, twist and Delta, that affect the embryonic development of Drosophila in known ways were used to examine the derivation and function of the outer layers of the central nervous system (CNS). Both the extracellular neural lamella, which ensheaths the CNS, and its source, the underlying perineurial sheath cell layer, fail to develop in Drosophila embryos that are homozygous for a loss of function mutation in the twist gene, and which thus lack mesodermal derivatives. The cell layer immediately below the perineurial sheath cells, here termed barrier glial cells, constitute the ion permeability barrier in wild‐type embryos. They are present in twist mutant embryos, appear to be normal at the ultrastructural level, and function as a blood‐brain ion barrier.
Desiccation and starvation resistance in Drosophila: patterns of variation at the species, population and intrapopulation levels

A substantial number of Drosophila studies have investigated variation in desiccation and starvation resistance, providing an opportunity to test for consistent patterns of direct and correlated responses across studies and across the species and population levels. In general, responses to laboratory selection for these traits in D. melanogaster are rapid and indicate abundant genetic variation in populations. However, slower responses to selection for desiccation resistance occur in other species including D. simulans. Clines suggest adaptive divergence although specific selection pressures have not been documented empirically. Drosophila species differ markedly in desiccation and starvation resistance and there is also marked variation within species for desiccation resistance that may be linked to local climatic conditions. Laboratory selection experiments on starvation resistance in D. melanogaster suggest that changes in lipid content are largely responsible for resistance variation but this factor may be less important in explaining variation among species. For desiccation, lines with increased resistance show reduced rates of water loss but no changes in the minimum water content that flies can tolerate. Changes in life history traits are sometimes associated with altered levels of stress resistance. Increased starvation resistance is associated with longer development time and reduced early age reproduction in different studies. However, other associations are inconsistent between studies as in the case of stress resistance changing following selection for longevity. Multiple mechanisms may underlie genetic variation in stress resistance and future studies should address the evolutionary importance of the different mechanisms at the population and species levels.
Towards Semantic User Query: A Review

This paper attempts to discuss the image query mechanisms and user needs for image retrieval. The explosive growth of image data leads to the need of research and development of Image retrieval. Image retrieval researches are moving from keyword, to low level features and to semantic features. Drive towards semantic features is due to the problem of the keywords which can be very subjective and time consuming while low level features cannot always describe high level concepts in the users’ mind. This paper also highlights both the already addressed and outstanding issues.