Miracle-dz/UniFAR-FTUs huggingface dataset:
Static analysis of thin plates by the boundary element method in a non-singular approach

A static analysis of Kirchhoff plates using the boundary element method has been presented in the paper. In this approach, there is no need to introduce Kirchhoff forces at the plate corner and equivalent shear forces at the plate boundary. The Bettie theorem has been used to derive the boundary integral equation. The collocation version of the boundary element method with “constant” type elements has been presented. The source points are located slightly outside the plate boundary, hence the quasi-diagonal integrals of fundamental functions are non-singular.
An Exosomal miRNA Biomarker for the Detection of Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) remains a difficult tumor to diagnose and treat. To date, PDAC lacks routine screening with no markers available for early detection. Exosomes are 40–150 nm-sized extracellular vesicles that contain DNA, RNA, and proteins. These exosomes are released by all cell types into circulation and thus can be harvested from patient body fluids, thereby facilitating a non-invasive method for PDAC detection. A bioinformatics analysis was conducted utilizing publicly available miRNA pancreatic cancer expression and genome databases. Through this analysis, we identified 18 miRNA with strong potential for PDAC detection. From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC. These 10 were examined for their mature miRNA expression patterns, giving rise to 18 mature miRs for further analysis. Exosomal RNA from cell culture media was analyzed via RTqPCR and seven mature miRs exhibited statistical significance (miR-31-5p, miR-31-3p, miR-210-3p, miR-339-5p, miR-425-5p, miR-425-3p, and miR-429). These identified biomarkers can potentially be used for early detection of PDAC.
A Theoretical Investigation of Low-Dimensional Bose-Einstein Condensations

Low-dimensional Bose-Einstein condensations (BEC) for g(e) (the density of states) = Cde(superscript d-1) with d ≤ 1, corresponding to a dimensionality of not larger than 2, are theoretically analyzed. When the energy quantization of the first excited state is taken into account, the boson number in the excited states is finite even for d ≤ 1 with the density of states remaining proportional toe(superscript d-1). The condensation temperature increases with the particle number faster for d ≤ 1 than for d ＞ 1. The condensation depends highly on the quantized energye1 of the first excited state. Whene1 just deviates slightly from zero, the condensation temperature quickly increases withe1. Theoretical estimation shows that a low-dimensional BEC can occur at a temperature above 1 K for excitons in semiconductor quantum wells even without the harmonic-oscillator potential.
Clinical and Prognostic Value of PPIA, SQSTM1, and CCL20 in Hepatocellular Carcinoma Patients by Single-Cell Transcriptome Analysis

Hepatocellular carcinoma (HCC) is the most malignant and poor-prognosis subtype of primary liver cancer. The scRNA-seq approach provides unique insight into tumor cell behavior at the single-cell level. Cytokine signaling in the immune system plays an important role in tumorigenesis and has both pro-tumorigenic and anti-tumorigenic functions. A biomarker of cytokine signaling in immune-related genes (CSIRG) is urgently required to assess HCC patient diagnosis and treatment. By analyzing the expression profiles of HCC single cells, TCGA, and ICGC data, we discovered that three important CSIRG (PPIA, SQSTM1, and CCL20) were linked to the overall survival of HCC patients. Cancer status and three hub CSIRG were taken into account while creating a risk nomogram. The nomogram had a high level of predictability and accuracy. Based on the CSIRG risk score, a distinct pattern of somatic tumor mutational burden (TMB) was detected between the two groups. The enrichment of the pyrimidine metabolism pathway, purine metabolism pathway, and lysosome pathway in HCC was linked to the CSIRG high-risk scores. Overall, scRNA-seq and bulk RNA-seq were used to create a strong CSIRG signature for HCC diagnosis.
General relativistic neutrino transport using spectral methods

We present a new code, Lorene's Ghost (for Lorene's gravitational handling of spectral transport) developed to treat the problem of neutrino transport in supernovae with the use of spectral methods. First, we derive the expression for the nonrelativistic Liouville operator in doubly spherical coordinates (r, θ, ϕ, ϵ, Θ, Φ), and further its general relativistic counterpart. We use the 3 + 1 formalism with the conformally flat approximation for the spatial metric, to express the Liouville operator in the Eulerian frame. Our formulation does not use any approximations when dealing with the angular arguments (θ, ϕ, Θ, Φ), and is fully energy-dependent. This approach is implemented in a spherical shell, using either Chebyshev polynomials or Fourier series as decomposition bases. It is here restricted to simplified collision terms (isoenergetic scattering) and to the case of a static fluid. We finish this paper by presenting test results using basic configurations, including general relativistic ones in the Schwarzschild metric, in order to demonstrate the convergence properties, the conservation of particle number and correct treatment of some general relativistic effects of our code. The use of spectral methods enables to run our test cases in a six-dimensional setting on a single processor.
Structural and Morphological Features of Hydroxyapatite Nanoparticles from Different Calcium Resources

: The shape of the growing crystals during creation of nano-hydroxyapatite materials is influenced critically by the source of calcium salt. Hydroxyapatite may be utilized in a wide range of applications due to its various morphological structures. Four samples of nano-hydroxyapatite were synthesized using inexpensive and readily available calcium salt sources. Samples have also been characterized and analyzed via XRD, FTIR, SEM, TG, and S BET methods. The weight losses for the HAp samples investigated varied from 1% to 3%, indicating that they were all thermally stable. During the interaction of various calcium ions with concentrated phosphoric acid, the presence of various anions throughout the preparation process acts as a structure shaping agent. Coral reef-shape, Sticks, nano-sheet and cotton-shape morphological structures resulted according to SEM analyses. All tested materials showed a high surface area following the order HA-Cl (162.73 m 2 /g) > HA-OH (136.32 m 2 /g) > HA-AC (135.27 m 2 /g) > HA-NO 3 (115.98 m 2 /g). The hydroxyapatites studied have crystallite sizes ranging from 14.85 to 25.72 nm, putting them on the Nano scale. Tested hydroxyapatite materials were effectively utilized to remove contaminants such as Fe 3+ and Mn 2+ from water with efficiencies of up to 95%. The total cost ranged from 258-386 EGP/100g (13.02-19.47) € /100g, including electricity costs.
Taking a Closer Look at Social Performance in Childhood Social Anxiety Disorder: Biopsychosocial Context Considerations and Effects of Cognitive Behavior Therapy

Models of social anxiety disorder (SAD) describe shortfalls in child social performance, whereas empirically, children often show a deficit only in subjective and not objective performance. We examined social performance in relation to possible changes (before and after cognitive behavior therapy [CBT] including social skills training) and to an objective parameter (vocal arousal). Children with SAD were expected to subjectively judge their behavior as less competent than healthy control (HC) children despite a lack of objective differences. Children receiving CBT were expected to show a change in subjective and objective social performance in comparison to children waiting for treatment. Exploratory correlation analyses were used to disentangle the relation between social performance and vocal arousal. One hundred and nineteen children (64 with and 55 without SAD; aged 9–13 years) completed a Trier Social Stress Test (TSST). Children with SAD participated in a second TSST after CBT or waiting. Performance was assessed by self-report and by blinded observers. Vocal arousal was analyzed by audio recording. Children with SAD were objectively assessed as more socially competent than HC children; subjectively, children with SAD showed lower social performance. CBT showed no effect on subjective or objective performance ratings. Vocal arousal did not correlate with social performance. Results need to be considered carefully, as psychometric problems appeared that had not been considered in previous studies. The surprising lack of CBT effects suggests a need to focus on cognitions surrounding social performance. Further, social skills training should not be a standard SAD treatment component but used only if necessary.
Cosmology with massive neutrinos II: on the universality of the halo mass function and bias

We use a large suite of N-body simulations to study departures from universality in halo abundances and clustering in cosmologies with non-vanishing neutrino masses. To this end, we study how the halo mass function and halo bias factors depend on the scaling variable σ2(M,z), the variance of the initial matter fluctuation field, rather than on halo mass M and redshift z themselves. We show that using the variance of the cold dark matter rather than the total mass field, i.e., σ2cdm(M,z) rather than σ2m(M,z), yields more universal results. Analysis of halo bias yields similar conclusions: when large-scale halo bias is defined with respect to the cold dark matter power spectrum, the result is both more universal, and less scale- or k-dependent. These results are used extensively in Papers I and III of this series.
Maternal Attachment, Peer Relationship and Behavior Problems among Primary School Children

Behavior problems that occur during childhood often persist into adolescence and they can also lead to various negative outcomes. Since mothers and peers play a significant role in developing children’s behavior, this study aimed to determine the relationship between maternal attachment and peer relationship with behavior problems among children. A total of 440 children aged between 10 to 11 were chosen by using the multistage cluster sampling technique. The data for this study were collected by using a self-administered questionnaire. The result indicated that maternal attachment posed a significantly negative relationship with behavior problems. The result also indicated that peer relationship was significantly and positively correlated with behavior problems. Meanwhile, multiple regression outcomes showed that peer relationships yielded the strongest influence on behavior problems. In conclusion, a good peer relationship is crucial to overcoming behavior problems among primary school children.
Interpretation of the diphoton excess at CMS and ATLAS

We consider the diphoton resonance at the 13 TeV LHC in a consistent model with new scalars and vector-like fermions added to the Standard Model, which can be constructed from orbifold grand unified theories and string models. The gauge coupling unification can be achieved, neutrino masses can be generated radiatively, and the electroweak vacuum stability problem can be solved. To explain the diphoton resonance, we study a spin-0 particle, and discuss various associated final states. We also constrain the couplings and number of the introduced heavy multiplets for the new resonance's width at 5 or 40 GeV.
EVALUATION OF MINERALIZED PLASMATIC MATRIX WITH AND WITHOUT COLLAGEN MEMBRANE IN ANTERIOR MAXILLARY HORIZONTAL ALVEOLAR DEFECT (RANDOMIZED CLINICAL TRIAL)

INTRODUCTION: Various grafting procedures and bone substitutes can be used to achieve optimum treatment outcome in cases with deficient bone volume. Recently, Mineralized Plasmatic Matrix (MPM) was introduced as an autologous blood product highly enriched in platelets and fibrin network in a liquid form combined with a bone substitute. OBJECTIVES: This study was conducted to compare the effect of mineralized plasmatic matrix (MPM) with and without collagen membrane as a bone regenerative material in anterior maxillary horizontal alveolar bone defect. MATERIAL AND METHODS: Sixteen patients with anterior maxillary horizontal alveolar defect were randomly divided into 2 equal groups. Delayed implant placement (Dentis s-clean system) was done for all patients followed by defect grafting with MPM in group 1 while in group 2 the defect was completely grafted with MPM then covered by collagen membrane . ; All implants were loaded after 3 months. Postoperatively, patients were followed up at immediately postoperative and at 3 for 9 months to clinically assess peri-implant probing depth and implant stability using Osstell® and to radiographically evaluate bone density, crestal bone loss and buccal bone thickness using CBCT. RESULTS: There was no statistically significant difference in peri-implant probing depth, implant stability, bone density, periimplant bone loss and buccal bone thickness between the two groups. However, there was a statistically significant increase in implant stability, bone density and buccal bone thickness between follow up periods in each group. CONCLUSION: Our results proved that MPM provides a more compact, durable and stable structure that helps the formation of new bone tissue without the use of a covering collagen membrane.
Does Disruption of Optic Atrophy-1 (OPA1) Contribute to Cell Death in HL-1 Cardiomyocytes Subjected to Lethal Ischemia-Reperfusion Injury?

Disruption of mitochondrial structure/function is well-recognized to be a determinant of cell death in cardiomyocytes subjected to lethal episodes of ischemia-reperfusion (IR). However, the precise mitochondrial event(s) that precipitate lethal IR injury remain incompletely resolved. Using the in vitro HL-1 cardiomyocyte model, our aims were to establish whether: (1) proteolytic processing of optic atrophy protein-1 (OPA1), the inner mitochondrial membrane protein responsible for maintaining cristae junction integrity, plays a causal, mechanistic role in determining cardiomyocyte fate in cells subjected to lethal IR injury; and (2) preservation of OPA1 may contribute to the well-documented cardioprotection achieved with ischemic preconditioning (IPC) and remote ischemic conditioning. We report that HL-1 cells subjected to 2.5 h of simulated ischemia displayed increased activity of OMA1 (the metalloprotease responsible for proteolytic processing of OPA1) during the initial 45 min following reoxygenation. This was accompanied by processing of mitochondrial OPA1 (i.e., cleavage to yield short-OPA1 peptides) and release of short-OPA1 into the cytosol. However, siRNA-mediated knockdown of OPA1 content did not exacerbate lethal IR injury, and did not attenuate the cardioprotection seen with IPC and a remote preconditioning stimulus, achieved by transfer of ‘reperfusate’ medium (TRM-IPC) in this cell culture model. Taken together, our results do not support the concept that maintenance of OPA1 integrity plays a mechanistic role in determining cell fate in the HL-1 cardiomyocyte model of lethal IR injury, or that preservation of OPA1 underlies the cardioprotection seen with ischemic conditioning.
Physical properties of high-mass clumps in different stages of evolution

Context. The details of the process of massive star formation are still elusive. A complete characterization of the first stages of the process from an observational point of view is needed to constrain theories on the subject. In the past 20 years we have made a thorough investigation of colour-selected IRAS sources over the whole sky. The sources in the northern hemisphere were studied in detail and used to derive an evolutionary sequence based on their spectral energy distribution. Aims. To investigate the first stages of the process of high-mass star formation, we selected a sample of massive clumps previously observed with the Swedish-ESO Submillimetre Telescope at 1.2 mm and with the ATNF Australia Telescope Compact Array at 1.3 cm. We want to characterize the physical conditions in such sources, and test whether their properties depend on the evolutionary stage of the clump. Methods. With ATCA we observed the selected sources in the NH3(1,1) and (2,2) transitions and in the H2O(616 − 523) maser line. Ammonia lines are a very good temperature probe that allow us to accurately determine the mass and the column, volume, and surface densities of the clumps. We also collected all data available to construct the spectral energy distribution of the individual clumps and to determine if star formation is already occurring through observations of its most common signposts, thus putting constraints on the evolutionary stage of the source. We fitted the spectral energy distribution between 1.2 mm and 70 μm with a modified black body to derive the dust temperature and independently determine the mass. Results. We find that the clumps are cold (T ∼ 10 − 30 K), massive (M ∼ 102 − 103 M ), and dense (n(H2) & 105 cm−3) and that they have high column densities (N(H2) ∼ 1023 cm−2). All clumps appear to be potentially able to form high-mass stars. The most massive clumps appear to be gravitationally unstable, if the only sources of support against collapse are turbulence and thermal pressure, which possibly indicates that the magnetic field is important in stabilizing them. Conclusions. After investigating how the average properties depend on the evolutionary phase of the source, we find that the temperature and central density progressively increase with time. Sources likely hosting a ZAMS star show a steeper radial dependence of the volume density and tend to be more compact than starless clumps.
Effectiveness of Organized Mammography Screening for Different Breast Cancer Molecular Subtypes

Simple Summary We evaluated the short-term effectiveness of a mammography screening program in all women who participated in the screening program and were diagnosed with screen-detected or interval breast cancer (BC) in Flanders (2008–2018). The evaluation was performed for the major molecular subtypes of invasive BC separately and considering the regularity of participation. We found that screen-detected BC was more likely to be diagnosed at early stages than interval BC of luminal, luminal-HER2-positive, and triple-negative BC (TNBC) type, but not for the human epidermal growth factor receptor 2-positive (HER2 positive) subtype. In addition, regular participation was related to a higher likelihood of screening detection than irregular participation for luminal, luminal-HER2-positive, and TNBC, but not for the HER2 positive subtype, either. Our results indicate that regular screening as compared to irregular screening is effective for all breast cancers except for the HER2 subtype. Abstract Background: Screening program effectiveness is generally evaluated for breast cancer (BC) as one disease and without considering the regularity of participation, while this might have an impact on detection rate. Objectives: To evaluate the short-term effectiveness of a mammography screening program for the major molecular subtypes of invasive BC. Methods: All women who participated in the screening program and were diagnosed with screen-detected or interval BC in Flanders were included in the study (2008–2018). Molecular subtypes considered were luminal and luminal-HER2-positive, human epidermal growth factor receptor 2-positive, and triple-negative BC (TNBC). The relationship between the BC stage at diagnosis (early (I–II) versus advanced (III–IV)) and the method of detection (screen-detected or interval) and the relationship between the method of detection and participation regularity (regular versus irregular) were evaluated by multi-variable logistic regression models. All models were performed for each molecular subtype and adjusted for age. Results: Among the 12,318 included women, BC of luminal and luminal-HER2-positive subtypes accounted for 70.9% and 11.3%, respectively. Screen-detected BC was more likely to be diagnosed at early stages than interval BC with varied effect sizes for luminal, luminal-HER2-positive, and TNBC with OR:2.82 (95% CI: 2.45–3.25), OR:2.39 (95% CI: 1.77–3.24), and OR:2.29 (95% CI: 1.34–4.05), respectively. Regular participation was related to a higher likelihood of screening detection than irregular participation for luminal, luminal-HER2-positive, and TNBC with OR:1.21 (95% CI: 1.09–1.34), OR: 1.79 (95% CI: 1.38–2.33), and OR: 1.62 (95% CI: 1.10–2.41), respectively. Conclusions: Regular screening as compared to irregular screening is effective for all breast cancers except for the HER2 subtype.
Bootstrap forecast of multivariate VAR models without using the backward representation

In this paper, we show how to simplify the construction of bootstrap prediction densities in multivariate VAR models by avoiding the backward representation. Bootstrap prediction densities are attractive because they incorporate the parameter uncertainty a any particular assumption about the error distribution. What is more, the construction of densities for more than one-step unknown asymptotically. The main advantage of the new simple without loosing the good performance of bootstrap procedures. Furthermore, by avoiding a backward representation, its asymptotic validity can be proved without relying on the assumption of Gaussian errors as proposed in this paper can be implemented to obtain prediction densities in models without a backward representation as, for example, models with MA components or GARCH disturbances. By comparing the finite sample performance of the proposed procedure with those of alternatives, we show that nothing is lost when using it. Finally, we implement the procedure to obtain prediction regions for US quarterly future inflation, unemployment and GDP growth
Low-Cost Antenna-Array-Based Metamaterials for Non-Invasive Early-Stage Breast Tumor Detection in the Human Body

Microstrip patch antennas have been used in many applications since their appearance. Despite their great promise, their narrow bandwidth and the loss at high-frequency bands have limited their usage in medical applications. This work proposes a developed low-cost microstrip patch antenna suitable for microwave imaging (MWI) applications within the wideband frequency range. The proposed antenna is loaded with an artificial magnetic conductor (AMC) to improve the antenna performance. The simulated results obtained using computer simulation technology (CST) indicate that the presence of the AMC has improved the frequency selectivity of the antenna at 8.6 GHz with a peak realized gain of 9.90443 dBi and 10.61 dBi for simulated and measured results, respectively. The proposed microstrip antenna has been fabricated to validate the simulated results, and its performance is tested experimentally. Additionally, the fidelity factor of face-to-face (FtF) and side-by-side (SbS) scenarios have been presented. The breast phantom models with a tumor and the antenna operating as a transceiver have been numerically simulated for the application of cancer tumor cell detection. The work will have a significant impact on the design of electromagnetic biosensors.