Miracle-dz/UniFAR-FTUs huggingface dataset:
Lymphoma models for B cell activation and tolerance. V. Anti-Ig mediated growth inhibition is reversed by phorbol myristate acetate but does not involve changes in cytosolic free calcium.

B cell lymphomas which can be growth inhibited by crosslinking their surface IgM receptors by anti-Ig reagents provide models for normal B cell regulation and tolerance. WEHI-231 and CH31 are two independently derived lines that are exquisitely sensitive to negative signalling by antibodies specific for mu or kappa chains, but are unaffected by antibodies against MHC class 1 or 2 antigens. In order to determine the mechanism of this growth inhibition as a model for tolerance, we have examined the roles played by protein kinase C activation and calcium mobilization/influx during negative signalling in these cells. We found that growth inhibition caused by anti-mu crosslinking was reversed in the presence of either phorbol myristate acetate (PMA) or by lipopolysaccharide (LPS) from E. coli. The effect of PMA on negative signalling was a true reversal since phorbol esters could be added after anti-mu treatment, thus allowing nearly normal cellular progression into the S phase of the cell cycle. In contrast, pretreatment with PMA did not provide protection against the growth inhibition from anti-mu. Indeed, a "desensitization" protocol demonstrated that PMA pretreatment actually decreased reversal by both PMA and LPS of the effects of anti-mu on B lymphoma growth. These studies suggest that both LPS and PMA act via at least one common intermediate, which is assumed to involve activation and translocation of protein kinase C. Analysis of changes in calcium ion concentration after treatment with anti-Ig reagents showed both mobilization from internal stores and influx via calcium channels in WEHI-231, as has been reported for normal B cells. However, these changes did not correlate with negative signalling for the several reasons. Firstly, anti-mu inhibition of the growth of WEHI-231 could be induced in the relative absence of extracellular Ca++ or in quin-2 loaded (buffered) cells. Secondly, pretreatment with high concentrations of PMA ablated calcium mobilization, yet failed to modulate growth inhibition in WEHI-231 cells. Moreover, LPS provided protection from the effects of anti-mu yet did not alter cellular [Cai++]. In addition, PMA posttreatment (under conditions causing a reversal of the effects of anti-mu) can be applied as long as four hours after the initial exposure to anti-mu and the rapid measurable changes in calcium flux. Indeed, such changes in intracellular free calcium occurred in elutriated WEHI-231 lymphoma cells at all phases of the cell cycle, although we have previously identified early G1 as the only critical period in which negative signalling can be delivered. (ABSTRACT TRUNCATED AT 400 WORDS)
Extraction of the Combination Rules of Colors and Derived Fashion Images Using Fashion Styling Data

—With the development of the Internet, people purchase various products online, with items for purchase being proposed on the basis of recommending algorithms. Fashion items are one of them. However, difficulties in recommending fashion items arise from problems in detecting the item's characteristics such as color, detail, and silhouette, in many still images on online shopping sites. In particular, color is a simple characteristic, but different color combinations give different impressions. Some people obtain a lovely and cute impression from the color combination of white and pink. Thus, this type of information is needed to focus on recommendation of items to users via the Internet. Our main aim in this study is to extract the rules related to the information described above, i.e., to obtain the associated rules from color combinations to derive impressions. We accumulated fashion styling data from online shopping sites related to fashion items. Then, we attempted to acquire the associated rules. After this procedure, we extracted approximately 6,000 rules. Subsequently, we tested the validity of the rules using questionnaires. The results demonstrated that our extracted rules were highly significant when compared with a controlled condition. Thus, we have successfully acquired association rules for fashion item recommendation.
Natural genetic variation of root system architecture from Arabidopsis to Brachypodium: towards adaptive value

Root system architecture is a trait that displays considerable plasticity because of its sensitivity to environmental stimuli. Nevertheless, to a significant degree it is genetically constrained as suggested by surveys of its natural genetic variation. A few regulators of root system architecture have been isolated as quantitative trait loci through the natural variation approach in the dicotyledon model, Arabidopsis. This provides proof of principle that allelic variation for root system architecture traits exists, is genetically tractable, and might be exploited for crop breeding. Beyond Arabidopsis, Brachypodium could serve as both a credible and experimentally accessible model for root system architecture variation in monocotyledons, as suggested by first glimpses of the different root morphologies of Brachypodium accessions. Whether a direct knowledge transfer gained from molecular model system studies will work in practice remains unclear however, because of a lack of comprehensive understanding of root system physiology in the native context. For instance, apart from a few notable exceptions, the adaptive value of genetic variation in root system modulators is unknown. Future studies should thus aim at comprehensive characterization of the role of genetic players in root system architecture variation by taking into account the native environmental conditions, in particular soil characteristics.
A Joint Coding-Precoding Scheme for OFDM Systems over Fading Channels

In this work we analyse the performance of a joint coding-precoding scheme for OFDM systems over fading channels. The design of the precoder is based on the information redistribution of the input modulated symbols amongst all the output precoded symbols. The proposed precoder decreases the variance of the instantaneous noise power at the receiver produced by the channel variability. In this sense, the noise at the output of the receiver deprecoding block can be considered as gaussian causing an improvement in the performance of the channel coding scheme employed in the system. The proposed system is evaluated under realistic radio channels which present multipath frequency-selective fadings and are affected by Doppler spread.
Study of Comparative Lyrics for Joy and Sad Emotions in Korean Popular Songs

As popular music grows, lyrics are taking a more important part of the pop music. In the thesis suggests that to prove that each can I maximize based on the lyrics' emotions, the study compares between a sense of cheerful and sad songs. For this reason, many emotional words were extracted by various word expressions in the cheerful songs and limited expressions of grief sensibilities were shown through relatively small amount of emotional words in the sorrowful songs.
Sella Turcica Morphology and Dimensions in Cleft Subjects

Objectives: Evaluate sella turcica morphology, calculate its size in cleft subjects, and compare it with noncleft subjects. Materials: Lateral cephalometric radiographs of 95 cleft and 190 noncleft individuals. Radiographs were divided into two groups by age: 11 to 14 years of age, 15 years and above. Main Outcome Measures: The morphology of the sella turcica was categorized into six shapes; whereas, the size of the sella turcica was measured in terms of length, depth, and diameter in millimeters. Results: The sella turcica was abnormal in shape in the majority of cleft subjects when compared with noncleft subjects (p = .0000), more so in subjects with unilateral cleft lip and palate and bilateral cleft lip and palate (p = .0000, p = .020, respectively). Depth of sella turcica was smaller in unilateral cleft lip and palate subjects (p = .037). A smaller sella turcica size (length, depth, diameter) was evident in cleft subjects as compared with noncleft subjects (p = .037, p = .004, p = .000, respectively). Age correlated positively with an increase in sella turcica size in both noncleft and cleft subjects (p = .000, p = .009, p = .000). Conclusions: A majority of cleft subjects displayed an abnormal appearance of sella turcica when compared with noncleft subjects. A smaller depth of sella turcica was associated with unilateral cleft lip and palate. The sella turcica was smaller in size in cleft subjects than in noncleft subjects. Sella turcica size increased with age in subjects with and without clefts.
toutvelu, a Regulator of Heparan Sulfate Proteoglycan Biosynthesis, Controls Guidance Cues for Germ-Cell Migration

The primitive embryonic gonad in Drosophila melanogaster is composed of germ cells and somatic gonadal precursor cells (SGPs). The assembly of a functional gonad involves a complex series of germ-cell migration events, which are thought to be guided by attractive and repulsive cues. Here, we demonstrate a novel role for toutvelu (ttv), a regulator of heparan sulfate proteoglycan biosynthesis during this process. Germline clonal analysis suggests that maternal deposition of ttv is required for proper germ-cell migration. Conversely, ectopic expression of ttv in early embryos results in severe germ-cell migration defects and inappropriate spreading of Hh protein. Moreover, overexpression of ttv in only the receiving cells, rather than in the sending cells, leads to phenotypic consequences. Finally, supporting the claim that the signaling molecule Hedgehog (Hh) may function as a chemoattractant to guide germ cells, errant germ cells are found localized near pockets containing high concentrations of Hh protein.
Predictors of adequacy of arteriovenous fistulas in hemodialysis patients.

BACKGROUND Dialysis access procedures and complications represent a major cause of morbidity, hospitalization, and cost for chronic dialysis patients. To improve the outcomes of hemodialysis access procedures, recent clinical guidelines have encouraged attempts to place an arteriovenous (A-V) fistula, rather than an A-V graft, whenever possible in hemodialysis patients. There is little information, however, about the success rate of following such an aggressive strategy in the prevalent dialysis population. METHODS We evaluated the adequacy of all A-V fistulas placed in University of Alabama at Birmingham dialysis patients during a two-year period. A fistula was considered adequate if it supported a blood flow of >/=350 ml/min on at least six dialysis sessions in one month. Fistula adequacy was correlated with clinical and demographic factors. RESULTS The adequacy could be determined for 101 fistulas; only 47 fistulas (46.5%) developed sufficiently to be used for dialysis. The adequacy rate was lower in older (age >/= 65) versus younger (age < 65) patients (30.0 vs. 53.5%, P = 0.03). It was also marginally lower in diabetics versus nondiabetics (35.0 vs. 54.1%, P = 0.061) and in overweight (BMI >/= 27 kg/m2) versus nonoverweight patients (34.5 vs. 55.2%, P = 0.07). The adequacy rate was not affected by patient race, smoking status, surgeon, serum albumin, or serum parathyroid hormone. The adequacy rate was substantially lower for forearm versus upper arm fistulas (34.0 vs. 58.9%, P = 0.012). The adequacy of forearm fistulas was particularly poor in women (7%), patients age 65 or older (12%), and diabetics (21%). In contrast, upper arm fistulas were adequate in 56% of women, 54% of older patients, and 48% of diabetics. CONCLUSIONS An aggressive approach to the placement of fistulas in dialysis patients results in a less than 50% early adequacy rate, which is considerably lower than that reported in the past. Moreover, the success rate of fistulas is even lower for certain patient subsets. To achieve an optimal outcome with A-V fistulas, we recommend that they be constructed preferentially in the upper arm in female, diabetic, and older hemodialysis patients.
Securing hierarchical multicast communications using roles

In multicast communications, where service providers distribute services such as streaming multimedia, distributed databases, and etc., an important issue is to control the access to both the transmitted data and the network resources. This issue becomes more complicated when the multicast communication takes place in a hierarchical organizational structure, such as the military. In this paper, we analyze the multicast security issues and propose a new approach to securing hierarchical multicast communications. Specifically, we specify requirements for developing access control policies in hierarchical multicast communications and propose a model for enforcing such policies. Our approach is based on the well-known role-based access control model. We show that our approach is simple, but yet is very flexible, scalable, and effective in controlling the access to the transmitted data as well as to the shared secret key, used in providing data confidentiality.
Evaluation of a Family-Centered Parenting Program for Culturally Diverse High-Risk Families

Follow this and additional works at: http://nsuworks.nova. edu/fse_etd Part of the Curriculum and Instruction Commons, Curriculum and Social Inquiry Commons, Educational Assessment, Evaluation, and Research Commons, Educational Methods Commons, Educational Sociology Commons, Family, Life Course, and Society Commons, Inequality and Stratification Commons, Other Education Commons, and the Quantitative, Qualitative, Comparative, and Historical Methodologies Commons
VISUALIZATION OF IMPACT ANALYSIS SOFTWARE AS A TOOL OF REVERSE ENGINEERING TECHNIQUE

Most of the system is not 100 % bugs free and need to maintain. These make the development team spent their time to read the entire source code that might be have more than 100,000 line of code to debug the error that exist in the system. Reverse Engineering technique will be use as the tools to assist the development team to understand the source code. Through the reverse engineering, the source code will be parsed to capture and identify the impact between artifacts via dependency. To more easy understand the source code, visualization will use as the supporter tools for impaction. In this paper, a researcher will focus on combination of Change Impact Analysis (CIA) and visualization later call Visualization of Impact Analysis (VIA) to assist development team do the system maintenance easier and efficient based on ObjectOriented Programming (OOP) in C++ language as a model to apply in the prototype.
A Comparison of the Effects of Massed Practice and Relaxation upon the Frequency of a Facial Tic

The effect of two treatments on a facial tic was examined experimentally. The subject, a 53-year-old male, carried out massed practice or relaxation for two periods of 5 min alternating with 5 min assessment periods during which he engaged in free conversation around key words. This was followed by a further two periods of the alternative treatment and intervening assessment periods. Pulse rate was monitored throughout and the procedure concluded with a 5 min period of covert assessment of tic frequency. Sessions were held on four consecutive days. Tic frequency was observed to increase following massed practice and marginally following relaxation. The latter treatment, however, was found to be effective in reducing tic frequency during the treatment block itself. The results are discussed in terms of the subject's general level of anxiety and the anxiety induced by the massed practice procedure.
Using Project Wiki History to Reflect on the Project Process

In this paper, we address the potential of project wikis to support reflection on the project process through participants' reconstruction of the project trajectory. Drawing on a case study of software engineering project work, we illustrate how information on project history can be found in a project wiki and may be used to support recall of and reflection on the process. We discuss implications for postmortem project reviews by considering how the utilization of project wikis could addresses some challenges to successful reviews. We also propose extended wiki functionality that can be used to make a more selective review of project history based on user-tagged contents.
The Yin–Yang Dynamics of DNA Methylation Is the Key Regulator for Smooth Muscle Cell Phenotype Switch and Vascular Remodeling

Objective— DNA methylation plays an important role in chronic diseases such as atherosclerosis, yet the mechanisms are poorly understood. The objective of our study is to indicate the regulatory mechanisms of DNA methylation in vascular smooth muscle cells (VSMCs) and its roles in atherosclerosis. Approach and Results— In ApoE−/− mice fed a Western diet, DNA methyltransferase inhibitor, 5-aza-2′-deoxycytidine, significantly attenuated atherosclerotic lesions (20.1±2.2% versus 30.8±7.5%; P=0.016) and suppressed DNA methyltransferase activity and concomitantly decreased global 5-methylcytosine content in atherosclerotic lesions of ApoE−/− mice. Using a carotid ligation model, we found that 5-aza-2′-deoxycytidine also dramatically inhibited neointimal formation (intimal area: 2.25±0.14×104 versus 4.07±0.22×104 &mgr;m2; P<0.01). Abnormal methylation status at the promoter of ten–eleven translocation 2, one of the key demethylation enzymes in mammals, was ameliorated after 5-aza-2′-deoxycytidine treatment, which in turn caused an increase in global DNA hydroxymethylation and 5-hydroxymethylcytosine enrichment at the promoter of Myocardin. In vitro, 5-aza-2′-deoxycytidine treatment or DNA methyltransferase 1 knockdown decreased global 5-methylcytosine content and restored Myocardin expression in VSMCs induced by platelet-derived growth factor, thus preventing excessive VSMCs dedifferentiation, proliferation, and migration. Furthermore, DNA methyltransferase 1 binds to ten–eleven translocation 2 promoter and is required for ten–eleven translocation 2 methylation in VSMCs. Conclusions— The inhibitory effects of DNA demethylation on global 5-methylcytosine content and ten–eleven translocation 2 hypermethylation in atherosclerotic aorta can recover 5-hydroxymethylcytosine enrichment at the Myocardin promoter and prevent VSMC dedifferentiation and vascular remodeling.
Fingerprint Geometric Hashing Based on Binary Minutiae Cylinder Codes

Identity management has become increasingly more difficult with biometric big data. Hash-based indexing methods are promising for efficient searches in the high-dimensional space. Geometric hashing is one of the popular methods and has seen many of its variants proposed in the literature for fingerprint identification. Most of them use the same real-valued measures of local geometric invariants for both index creation and feature comparison. In this paper, we propose to build a 3D geometric hash table for storing binary minutiae cylinder codes with access keys that collectively describe the global geometric configuration. The proposed scheme is more robust against sample noise and distortion, and its most computation intensive part can be done efficiently in Hamming space. We perform fingerprint indexing experiments on the public benchmark databases of FVC2002 DB1 and NIST DB14. The results show that the performance of our approach can converge faster to high hit rates with lower penetration rates compared to other hash-based fingerprint indexing methods.
Addressing Email Loss with SureMail: Measurement, Design, and Evaluation

We consider the problem of silent email loss in the Internet, where neither the sender nor the intended recipient is notified of the loss. Our detailed measurement study over several months shows a silent email loss rate of 0.71% to 1.02%. The silent loss of an important email can impose a high cost on users. We further show that spam filtering can be the significant cause of silent email loss, but not the sole cause. SureMail augments the existing SMTP-based email infrastructure with a notification system to make intended recipients aware of email they are missing. A notification is a short, fixed-format fingerprint of an email, constructed so as to preserve sender and recipient privacy, and prevent spoofing by spammers. SureMail is designed to be usable immediately by users without requiring the cooperation of their email providers, so it leaves the existing email infrastructure (including anti-spam infrastructure) untouched and does not require a PKI for email users. It places minimal demands on users, by automating the tasks of generating, retrieving, and verifying notifications. It alerts users only when there is actual email loss. Our prototype implementation demonstrates the effectiveness of SureMail in notifying recipients upon email loss.
AlN-on-Si SAW filters: influence of film thickness, IDT geometry and substrate conductivity

In this paper we analyze the frequency response of surface acoustic wave (SAW) filters built on (00·2)-oriented AlN films deposited on silicon substrates. The experimental scattering parameters (Sij) of the filters were fitted using our own circuital model that takes into account the theoretical response of the ideal SAW along with all the external and internal parasitic effects. We discuss the relation between the different circuital elements and the physical properties of the SAW device (geometry, substrate resistivity, thickness of the piezoelectric layer, etc.) and the parasitic effects due to the packaging and the wire bonding. On the basis of this analysis, some guidelines for the design of SAW structures with an optimum frequency response are given.
A Rare Case of Recurrent Alpha-fetoprotein-producing Gastric Cancer without Re-elevation of Serum AFP

We report an extremely rare case of recurrent alpha-fetoprotein (AFP)-producing gastric cancer without re-elevation of serum AFP. The patient was a 78-year-old woman with AFP-producing gastric cancer, a rare type of gastric adenocarcinoma. A Borrmann III gastric tumour was surgically resected and AFP-producing gastric cancer was diagnosed based on high levels of serum AFP (705.44 ng/ml) and immunohistochemical examination of the tumour. The serum AFP level decreased to the normal range after resection without any sign of recurrence by imaging, but the patient developed local recurrence of the cancer and died 13 months after surgery. No re-elevation of serum AFP levels was observed after recurrence. Although serum AFP levels are believed to be useful for follow-up in the post-operative period, the possibility that serum AFP levels do not always correlate with the extent of the cancer should be kept in mind.