Miracle-dz/UniFAR-FTUs huggingface dataset:
Effective biomodulation by leucovorin of high-dose infusion fluorouracil given as a weekly 24-hour infusion: results of a randomized trial in patients with advanced colorectal cancer.

PURPOSE To determine whether high-dose infusional fluorouracil (FU) is effectively modulated by leucovorin (LV), interferon (IFN) alpha-2b, or both when given to patients with metastatic colorectal cancer. PATIENTS AND METHODS Patients (n = 236) with progressive, measurable disease were randomized to three groups and received FU 2,600 mg/m2 as a 24-hour continuous infusion (CI) weekly for 6 weeks with 2 weeks rest (FU24h) and LV 500 mg/m2 as a 2-hour infusion before FU or IFN 3 x 10(6) U subcutaneously 3 times weekly or both. Treatment continued until progressive disease or unacceptable toxicity was observed. Pairs of treatment arms were analyzed sequentially to detect equivalence or a 25% difference in response rates. RESULTS The rate of objective remission in patients who received FU24h/LV (44%; 40 of 91) was significantly higher than in patients who received FU24h/IFN (18%; 16 of 90; P < .05). The response rates of patients who received FU24h/LV versus FU24h/LV/IFN (27%; 13 of 49) were statistically equivalent. Significant differences were observed for time to tumor progression (TTP) (FU24h/LV, 7.1 months; FU24h/IFN, 3.9 months; FU24h/LV/IFN, 6.3 months; global P value < .009) and survival (16.6 months, 12.7 months, 19.6 months, respectively; global P value < .04). Unpredictable and life-threatening toxicity in the FU24h/LV/IFN arm required dose reduction of FU to 2,000 mg/m2/day and early stoppage of this arm. Toxicity was manageable in patients who received both FU24h/LV (grade 3 to 4 diarrhea, 21%) and FU24h/IFN (grade 3 to 4 diarrhea, 15%). CONCLUSION Response rate, TTP, and overall survival were superior for LV-containing regimens compared with IFN modulation alone. The addition of IFN to high-dose infusional FU plus LV offers no advantage and may increase toxicity. The regimen of high-dose infusional FU24h/LV warrants further evaluation in patients with metastatic colorectal cancer.
Animal Foraging and the Evolution of Goal-Directed Cognition

Foraging- and feeding-related behaviors across eumetazoans share similar molecular mechanisms, suggesting the early evolution of an optimal foraging behavior called area-restricted search (ARS), involving mechanisms of dopamine and glutamate in the modulation of behavioral focus. Similar mechanisms in the vertebrate basal ganglia control motor behavior and cognition and reveal an evolutionary progression toward increasing internal connections between prefrontal cortex and striatum in moving from amphibian to primate. The basal ganglia in higher vertebrates show the ability to transfer dopaminergic activity from unconditioned stimuli to conditioned stimuli. The evolutionary role of dopamine in the modulation of goal-directed behavior and cognition is further supported by pathologies of human goal-directed cognition, which have motor and cognitive dysfunction and organize themselves, with respect to dopaminergic activity, along the gradient described by ARS, from perseverative to unfocused. The evidence strongly supports the evolution of goal-directed cognition out of mechanisms initially in control of spatial foraging but, through increasing cortical connections, eventually used to forage for information.
High-efficiency dual-axis solar tracking developement using Arduino

The renewable-energy sector is fast gaining ground as a new growth area for numerous countries with the vast potential it presents environmentally and economically. Solar energy plays an important role as a primary source of energy, especially for rural area. This paper presents the design and development of high-efficiency dual-axis solar tracking system using Arduino platform. Furthermore, the ultimate objective of this project is to trace the maximum sunlight source to power the solar panel. The project is divided into two stages, which are hardware and software development. In hardware development, five light dependent resistor (LDR) has been used for capturing maximum light source. Two servo motors have been used to move the solar panel at maximum light source location sensing by LDR. Moreover, the code is constructed using C programming language and targeted to Arduino UNO controller. The efficiency of the system has been tested and compared with static solar panel on several time intervals, and it shows the system react the best at the 10-minutes intervals with consistent voltage generated. Therefore, the system has been proven working for capturing the maximum sunlight source for high efficiency solar harvesting applications.
Domain Exchange between Human Toll-like Receptors 1 and 6 Reveals a Region Required for Lipopeptide Discrimination*

Among the 10 human Toll-like receptors (TLRs), TLR2 appears to be unique in its requirement for cooperation with other TLRs, namely TLR1 and TLR6, to mediate cell signaling. Through reconstitution experiments, we have defined more precisely the function of these human TLRs. Human colonic epithelial cells cotransfected with TLR1 and -2 preferentially respond to a synthetic tripalmitoylated bacterial lipopeptide analogue (Pam3CSK4). However, examination of a wide variety of lipopeptide derivatives indicates that recognition by human TLR1 and -2 does not strictly correlate with the number or position of the acyl chains on the modified cysteine residue. Conversely, human TLR2 and -6 exclusively respond to lipopeptides possessing a diacylglycerol group. Most surprisingly, we have found that an R stereoisomer of diacylated macrophage-activating lipopeptide 2 (MALP-2) exclusively activates epithelial cells through TLR6 and -2 but not through TLR1 and -2. These results suggest that the chirality of the central carbon of the diacylglycerol group of these agonists is a structural determinant for human TLR recognition. Examination of chimeric receptors, generated by domain exchange between TLR1 and -6, has revealed that leucine-rich repeats 9–12 of the extracellular domain enable these receptors to discriminate between structurally similar lipopeptides. However, additional chimeric constructs reveal that this region alone is not sufficient to generate receptors that can functionally cooperate with TLR2. Our results support the idea that TLR1 and TLR6 diverged during evolution to differentially recognize natural lipoprotein structures and that this function has been conserved with respect to the human receptors.
Drosophila Aurora B Kinase Is Required for Histone H3 Phosphorylation and Condensin Recruitment during Chromosome Condensation and to Organize the Central Spindle during Cytokinesis

Aurora/Ipl1-related kinases are a conserved family of enzymes that have multiple functions during mitotic progression. Although it has been possible to use conventional genetic analysis to dissect the function of aurora, the founding family member in Drosophila (Glover, D.M., M.H. Leibowitz, D.A. McLean, and H. Parry. 1995. Cell. 81:95–105), the lack of mutations in a second aurora-like kinase gene, aurora B, precluded this approach. We now show that depleting Aurora B kinase using double-stranded RNA interference in cultured Drosophila cells results in polyploidy. aurora B encodes a passenger protein that associates first with condensing chromatin, concentrates at centromeres, and then relocates onto the central spindle at anaphase. Cells depleted of the Aurora B kinase show only partial chromosome condensation at mitosis. This is associated with a reduction in levels of the serine 10 phosphorylated form of histone H3 and a failure to recruit the Barren condensin protein onto chromosomes. These defects are associated with abnormal segregation resulting from lagging chromatids and extensive chromatin bridging at anaphase, similar to the phenotype of barren mutants (Bhat, M.A., A.V. Philp, D.M. Glover, and H.J. Bellen. 1996. Cell. 87:1103–1114.). The majority of treated cells also fail to undertake cytokinesis and show a reduced density of microtubules in the central region of the spindle. This is accompanied by a failure to correctly localize the Pavarotti kinesin-like protein, essential for this process. We discuss these conserved functions of Aurora B kinase in chromosome transmission and cytokinesis.
Nutrigenomics and nutrigenetics: the emerging faces of nutrition

The recognition that nutrients have the ability to interact and modulate molecular mechanisms underlying an organism's physiological functions has prompted a revolution in the field of nutrition. Performing population‐scaled epidemiological studies in the absence of genetic knowledge may result in erroneous scientific conclusions and misinformed nutritional recommendations. To circumvent such issues and more comprehensively probe the relationship between genes and diet, the field of nutrition has begun to capitalize on both the technologies and supporting analytical software brought forth in the post‐genomic era. The creation of nutrigenomics and nutrigenetics, two fields with distinct approaches to elucidate the interaction between diet and genes but with a common ultimate goal to optimize health through the personalization of diet, provide powerful approaches to unravel the complex relationship between nutritional molecules, genetic polymorphisms, and the biological system as a whole. Reluctance to embrace these new fields exists primarily due to the fear that producing overwhelming quantities of biological data within the confines of a single study will submerge the original query; however, the current review aims to position nutrigenomics and nutrigenetics as the emerging faces of nutrition that, when considered with more classical approaches, will provide the necessary stepping stones to achieve the ambitious goal of optimizing an individual's health via nutritional intervention. Mutch, D. M. , Wahli, W. , Williamson, G. Nutrigenomics and nutrigenetics: the emerging faces of nutrition. FASEB J. 19, 1602–1616 (2005)
Shape guided contour grouping with particle filters

We propose a novel framework for contour based object detection and recognition, which we formulate as a joint contour fragment grouping and labeling problem. For a given set of contours of model shapes, we simultaneously perform selection of relevant contour fragments in edge images, grouping of the selected contour fragments, and their matching to the model contours. The inference in all these steps is performed using particle filters (PF) but with static observations. Our approach needs one example shape per class as training data. The PF framework combined with decomposition of model contour fragments to part bundles allows us to implement an intuitive search strategy for the target contour in a clutter of edge fragments. First a rough sketch of the model shape is identified, followed by fine tuning of shape details. We show that this framework yields not only accurate object detections but also localizations in real cluttered images.
Reproductive health counseling delivered to women living with HIV in the United States

ABSTRACT Advances in antiretroviral therapy (ART) and reproductive technologies have made transmission of HIV to partners and infants almost completely preventable. Comprehensive reproductive health counseling (CRHC) is an important component of care for women living with HIV, but few women report discussing reproductive health with an HIV care provider. We surveyed a probability sample of U.S. HIV care providers during 2013–2014. Of 2023 eligible providers, 1234 responded (64% adjusted provider response rate). We estimated the percentage delivering CRHC to their female patients. CRHC was defined as delivering each of five components of reproductive health care to most or all female patients. We assessed associations between provider characteristics and delivering CRHC using chi-squared tests and multivariable logistic regression. Of all providers, 49% (95% confidence interval [CI], 42–55) reported delivering all components of CRHC: 71% assessed reproductive intentions of reproductive-aged women, 78% explained perinatal transmission risk, 87% discussed ART for preventing perinatal transmission, 76% provided contraception as appropriate, and 64% provided referrals for preconception care. Among providers who offered primary care (83% of sample), 52% (CI: 44–60) delivered CRHC compared to 33% (CI: 22–44) of providers who did not offer primary care (P = .01). More female providers (46% of sample) compared to male providers delivered CRHC (57% [CI: 48–65] vs. 40% [CI: 31–50], P < .01). Delivery of CRHC by providers did not differ by patient caseload. After adjusting for gender, years of HIV experience, and patient caseload, providing primary care to HIV-infected patients remained associated with delivering CRHC (adjusted prevalence ratio [aPR] 1.48, 95% CI 1.02–2.16). Provider delivery of CRHC is not consistent with current guidelines that recommend discussing reproductive health with all reproductive-aged women who are living with HIV, even among providers offering primary care to their HIV patients.
Cells of origin, course, and termination patterns of the ventral, uncrossed component of the mature rat corticospinal tract

The cells of origin, the course, and termination patterns of the ventral, uncrossed component of the rat corticospinal tract (CST) was investigated by using retrograde and anterograde tracing methods. Anterograde tracing with biotin dextran‐amine (BDA) revealed the position and detailed morphology of CST fibers in the spinal cord. Cross sections on spinal levels C4, T8, and L4 showed labeled fibers in the ipsilateral ventral funiculus on all levels. Although ipsilateral ventral CST fibers run close to the midline in the cervical cord, they were found to disperse more in the ventromedial funiculus at lower spinal levels. To study the termination patterns of the ipsilateral ventral projection, a dorsal spinal cord hemisection was performed at level T8, severing the crossed dorsomedial and dorsolateral components but leaving ipsilateral ventral running fibers intact. These fibers were observed to have sometimes several collaterals with terminal arbors extending into different spinal segments, innervating mostly laminae III–VI. Structures closely resembling synaptic boutons were identified in these arbors. By retrograde tracing in animals with dorsal spinal cord hemisection, we found labeled cells equally distributed throughout the spinally projecting cortical areas corresponding to the level of tracer injection. Labeled cells were found in layer V. The diameter of the labeled cells was not significantly different from other spinally projecting cortical neurons. In summary, a neuroanatomically complete ipsilateral, ventral corticospinal projection down to low spinal levels was found. The large extension of the terminal arborizations in intermediate laminae of the spinal cord suggests a modulatory role of this CST component. J. Comp. Neurol. 386:293–303, 1997. © 1997 Wiley‐Liss, Inc.
Continuous Time Bayesian Network Reasoning and Learning Engine

We present a continuous time Bayesian network reasoning and learning engine (CTBN-RLE). A continuous time Bayesian network (CTBN) provides a compact (factored) description of a continuous-time Markov process. This software provides libraries and programs for most of the algorithms developed for CTBNs. For learning, CTBN-RLE implements structure and parameter learning for both complete and partial data. For inference, it implements exact inference and Gibbs and importance sampling approximate inference for any type of evidence pattern. Additionally, the library supplies visualization methods for graphically displaying CTBNs or trajectories of evidence.
Delineating the Role of Histamine-1- and -4-Receptors in a Mouse Model of Th2-Dependent Antigen-Specific Skin Inflammation

Background Histamine drives pruritus in allergic skin diseases which clinically constitutes a most disruptive symptom. Skin pathology in allergic skin diseases is crucially influenced by different T-helper subsets. However, the contribution of different histamine-receptors to T-helper cell dependent skin pathology has not been definitively answered. Models which can specifically address the functional role of T-helper subsets and the mediators involved are therefore valuable to gain further insights into molecular pathways which contribute to allergic skin disease. They might also be helpful to probe amendable therapeutic interventions such as histamine-receptor antagonism. Objective Establishing an adoptive transfer model for antigen-specific Th cells, we aimed to delineate the role of histamine H1- and H4-receptors in Th2-dependent skin inflammation. Methods In-vitro differentiated and OVA primed Th2 cells were adoptively transferred into congenic recipient mice. In vivo treatment with specific histamine H1- and H4-receptor antagonists was performed to analyze the contribution of these histamine-receptors to Th2-dependent skin pathology in our model. Analysis four days after epicutaneous challenge comprised skin histology, flow cytometric detection of transferred T-helper cells and analysis of antigen-cytokine profiles in skin-draining lymph nodes. Results Use of specific H1- and H4-receptor antagonists revealed a crucial role for H1- and H4-receptors for Th2 migration and cytokine secretion in a Th2-driven model of skin inflammation. While H1- and H4-receptor antagonists both reduced Th2 recruitment to the site of challenge, local cytokine responses in skin-draining lymph nodes were only reduced by the combined application of H1- and H4-receptor antagonists and mast cell counts remained altogether unchanged by either H1R-, H4R- or combined antagonism. Conclusion Our model demonstrates a role for H1- and H4-receptors in Th2 cell infiltration and cytokine secretion in allergic skin diseases and suggests further studies to evaluate these findings for therapeutic approaches.
Sickrole Compliance and Sickrole Deviance among Tuberculosis Patients on Treatment in Kanyama, a Zambian Shanty Compound

Background: Kanyama compound has had a DOTS community based programme since 2012 where TB supporters in the community have been fostering the DOTS programme. Prior to this study, research had not been done using Parsonian sickrole behaviour concept to determine the pattern of deviance especially the sickrole behavioural responses on the part of people who were on TB treatment. Methods: This was an exploratory study and the study sample was drawn from a large mixed methods study (quan + QUAL) comprising of 457 men and women ≥15 years. Enrolees were disproportionately sampled using systematic sampling from a population of 1126 men and women who were on multi drug therapy over a two-year period. Categorical and numeric data from the tool was cleaned and analyzed by using SPSS version 21 (Inc., Chicago, USA). Statistical analysis was done using Pearson’s Chi square test and ANOVA. A p value of p p < 0.05 between case type and marital status. Conclusions: Strengthening DOTS programs at community level through volunteers to enhance patient adherence to TB treatment and giving personalised attention to men and women who may be at risk of developing secondary tuberculosis, or risk for drug resistance and even dying is recommended. There is evidence to laud the great effort being expended by volunteer community based tuberculosis supporters in ensuring that what DOTS stands for is met.
Impact of myocardial haemorrhage on left ventricular function and remodelling in patients with reperfused acute myocardial infarction.

AIMS Myocardial haemorrhage is a common complication following reperfusion of ST-segment-elevation acute myocardial infarction (MI). Although its presence is clearly related to infarct size, at present it is unknown whether post-reperfusion haemorrhage affects left ventricular (LV) remodelling. Magnetic resonance imaging (MRI) can be used to identify MI, myocardial haemorrhage, and microvascular obstruction (MVO), as well as measure LV volumes, function, and mass. METHODS AND RESULTS Ninety-eight patients (14 females, 84 males, mean age: 57.7 years) with MI reperfused with percutaneous coronary intervention (PCI) were studied within the first week (1W) and at 4 months (4M) after the event. T2-weighted MRI was used to differentiate between haemorrhagic (i.e. hypointense core) and non-haemorrhagic infarcts (i.e. hyperintense core). Microvascular obstruction and infarct size were determined on contrast-enhanced MRI, whereas cine MRI was used to quantify LV volumes, mass, and function. Twenty-four patients (25%) presented with a haemorrhagic MI. In the acute phase, the presence of myocardial haemorrhage was related to larger infarct size and infarct transmurality, lower LV ejection fraction, and lower systolic wall thickening in the infarcted myocardium (all P-values <0.001). At 4M, a significant improvement in LV ejection fraction in patients with non-haemorrhagic MI was seen (baseline: 49.3 +/- 7.9% vs. 4M: 52.9 +/- 8.1%; P < 0.01). Left ventricular ejection fraction did, however, not improve in patients with haemorrhagic MI (baseline: 42.8 +/- 6.5% vs. 4M: 41.9 +/- 8.5%; P = 0.68). Multivariate analysis showed myocardial haemorrhage to be an independent predictor of adverse LV remodelling at 4M (defined as an increase in LV end-systolic volume). This pattern was independent of the initial infarct size. CONCLUSION Myocardial haemorrhage, the presence of which can easily be detected with T2-weighted MRI, is a frequent complication after successful myocardial reperfusion and an independent predictor of adverse LV remodelling regardless of the initial infarct size.
Legal application ontology in Arabic

This paper describes the construction of an application ontology for the legal domain. This ontology covering the semantic content of jurisprudence decisions can be deployed at several levels in our system for decisions research: improve the results of decision structuring, facilitate queries' formulation when accessing the system and finally optimize the search of decisions. We begin by presenting the methodology we have adopted for the ontology construction from textual jurisprudence decisions. We concentrate on the conceptualization stage by presenting our formal approach based on top level ontology as DOLCE and a core legal ontology. Then we will detail the deployment of the ontology at JDSM, the methodology of decision structuring decision that we have proposed.
Curriculum Q-Learning for Visual Vocabulary Acquisition

The structure of curriculum plays a vital role in our learning process, both as children and adults. Presenting material in ascending order of difficulty that also exploits prior knowledge can have a significant impact on the rate of learning. However, the notion of difficulty and prior knowledge differs from person to person. Motivated by the need for a personalised curriculum, we present a novel method of curriculum learning for vocabulary words in the form of visual prompts. We employ a reinforcement learning model grounded in pedagogical theories that emulates the actions of a tutor. We simulate three students with different levels of vocabulary knowledge in order to evaluate the how well our model adapts to the environment. The results of the simulation reveal that through interaction, the model is able to identify the areas of weakness, as well as push students to the edge of their ZPD. We hypothesise that these methods can also be effective in training agents to learn language representations in a simulated environment where it has previously been shown that order of words and prior knowledge play an important role in the efficacy of language learning.