Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence of pressure ulcer and associated risk factors in middle‐ and older‐aged medical inpatients in Norway

AIMS AND OBJECTIVES To describe the prevalence of pressure ulcers among middle- and older-aged patients in a general medical hospital in Norway and to describe the associations between pressure ulcers and potential risk factors additional to the Braden risk score. BACKGROUND Degrees of mobility, activity, perfusion and skin status are risk factors for development of pressure ulcer. Nurses' clinical judgements combined with risk assessment tools are effective to detect pressure ulcer risk. DESIGN Cross-sectional study. METHODS The study was performed as part of a research project conducted between September 2012-May 2014 in a general hospital in the capital of Norway. Registered nurses and nursing students collected data from all eligible patients on 10 days during the students' clinical practice studies. The Braden scale was used to measure pressure ulcer risk, and skin examinations were performed to classify the skin area as normal or as indicative of pressure ulcer according to the definitions by the National Pressure Ulcer Advisory Panel. Comorbidities were collected by patient's self-report. This analysis focused on the 255 inpatients at the medical wards ≥52 years of age, most of whom had more than one comorbidity. RESULTS The prevalence of pressure ulcers was 14.9% in this sample. Higher age, underweight, diabetes and worse Braden scores were factors associated with pressure ulcer, and pressure ulcer was most frequently sited at the sacrum or heel. CONCLUSION Adding age, weight and diabetes status to pressure ulcer risk assessment scales may improve identification of patients at risk for pressure ulcers. RELEVANCE TO CLINICAL PRACTICE Knowledge about strengths and limitations of risk assessment tools is important for clinical practice. Age, weight and diabetes status should be considered for inclusion in risk assessment tools for pressure ulcers in medical wards.
Remoteness influences access to sexual partners and drives patterns of viral sexually transmitted infection prevalence among nomadic pastoralists

Sexually transmitted infections (STIs) comprise a significant portion of the infectious-disease burden among rural people in the Global South. Particular characteristics of ruralness—low-density settlements and poor infrastructure—make healthcare provision difficult, and remoteness, typically a characteristic of ruralness, often compounds the difficultly. Remoteness may also accelerate STI transmission, particularly that of viral STIs, through formation of small, highly connected sexual networks through which pathogens can spread rapidly, especially when partner concurrency is broadly accepted. Herein, we explored the effect of remoteness on herpes simplex virus type-2 (HSV-2) epidemiology among semi-nomadic pastoralists in northwestern (Kaokoveld) Namibia, where, in 2009 we collected HSV-2-specific antibody status, demographic, sexual network, and travel data from 446 subjects (women = 213, men = 233) in a cross-sectional study design. HSV-2 prevalence was high overall in Kaokoveld (>35%), but was heterogeneously distributed across locally defined residential regions: some regions had significantly higher HSV-2 prevalence (39–48%) than others (21–33%). Using log-linear models, we asked the following questions: 1) Are sexual contacts among people in high HSV-2-prevalence regions more likely to be homophilous (i.e., from the same region) than those among people from low-prevalence regions? 2) Are high-prevalence regions more “functionally” remote, in that people from those regions are more likely to travel within their own region than outside, compared to people from other regions? We found that high-prevalence regions were more sexually homophilous than low-prevalence regions and that those regions also had higher rates of within-region travel than the other regions. These findings indicate that remoteness can create contact structures for accelerated STI transmission among people who are already disproportionately vulnerable to consequences of untreated STIs.
Characterization of Copy Number Variation’s Potential Role in Marek’s Disease

Marek’s Disease (MD) is a highly contagious pathogenic and oncogenic disease primarily affecting chickens. Chicken Lines 63 and 72, as well as their recombinant congenic strains (RCS) with varied susceptibility to MD, are ideal models to study the complex mechanisms of genetic resistance to MD. In this study, we investigated copy number variation (CNV) in these inbred chicken lines using the Affymetrix Axiom HD 600 K SNP genotyping array. We detected 393 CNV segments across all ten chicken lines, of which 12 CNVs were specifically identified in Line 72. We then assessed genetic structure based on CNV and observed markedly different patterns. Finally, we validated two deletion events in Line 72 and correlated them with genes expression using qPCR and RNA-seq, respectively. Our combined results indicated that these two CNV deletions were likely to contribute to MD susceptibility.
Understanding Progressive Multifocal Leukoencephalopathy Risk in Multiple Sclerosis Patients Treated with Immunomodulatory Therapies: A Bird’s Eye View

The increased use of newer potent immunomodulatory therapies for multiple sclerosis (MS), including natalizumab, fingolimod, and dimethyl fumarate, has expanded the patient population at risk for developing progressive multifocal leukoencephalopathy (PML). These MS therapies shift the profile of lymphocytes within the central nervous system (CNS) leading to increased anti-inflammatory subsets and decreased immunosurveillance. Similar to MS, PML is a demyelinating disease of the CNS, but it is caused by the JC virus. The manifestation of PML requires the presence of an active, genetically rearranged form of the JC virus within CNS glial cells, coupled with the loss of appropriate JC virus-specific immune responses. The reliability of metrics used to predict risk for PML could be improved if all three components, i.e., viral genetic strain, localization, and host immune function, were taken into account. Advances in our understanding of the critical lymphocyte subpopulation changes induced by these MS therapies and ability to detect viral mutation and reactivation will facilitate efforts to develop these metrics.
A Novel Semi-Supervised Dimensionality Reduction Framework

In pattern recognition, when a dataset contains multiple classes, and the structures of the classes are different, single manifold assumption can hardly guarantee the best classification performance. It is more reasonable to assume each class lies on a separate manifold. Here, the authors propose a novel framework of semisupervised dimensionality reduction for multimanifold learning. To address the issue of label insufficiency under the multimanifold assumption, they propose solving three challenging problems: clustering unlabeled samples into different manifolds using sparse manifold clustering, even when they are close to each other; predicting the label of image sets instead of a single sample by calculating the manifold-to-manifold distance; and constructing three kinds of graphs for each manifold to exploit more information from unlabeled samples. During the investigation, they demonstrated that most existing dimension-reduction methods based on manifold learning can be viewed as special cases of the proposed framework. Experimental results verify the advantages and effectiveness of this new framework.
Evaluation of surgical wound segmentation using quantitative analysis

To provide assistance to medical practitioners in wound care, numerous studies have been developing clinical decision support tools for wound monitoring and tracing. Image segmentation is the foundation of image analysis. A superior segmentation could address further image analysis and accurately interpret an image even with background noise. However, the segmentation performance of the wound using objective quantitative analysis has not been well-documented. In this study, we evaluated the segmentation algorithm based on the Canny edge detector and genetic algorithm along with a quantitative objective analysis based on empirical objective and precision-recall measure. According to a majority vote among three surgeons as the gold standard for over 100 wound images, the results revealed that the proposed segmentation algorithm achieved 89% accuracy (95% confidence interval: 87.5--90.6) for wound region detection. In conclusion, the proposed segmentation detector is robust and reliable enough to perform further image analysis. The findings provide further support to evaluate image segmentation as a part of image processing.
Brentuximab vedotin prior to allogeneic stem cell transplantation in Hodgkin lymphoma: a report from the EBMT Lymphoma Working Party

Brentuximab vedotin (BV) is an anti‐CD30 antibody‐drug conjugate. Preliminary data suggest that BV might improve outcomes after allogeneic stem cell transplantation (SCT) for Hodgkin lymphoma (HL) when used as pre‐transplant salvage therapy. Between 2010 and 2014, 428 adult patients underwent an allogeneic SCT for classical HL at participating centres of the European Society for Blood and Marrow Transplantation. We compared the outcomes of 210 patients who received BV prior to allogeneic SCT with that of 218 patients who did not receive BV. The median follow‐up for survivors was 41 months. Patients in the BV group were more heavily pre‐treated (median pre‐allograft treatment lines: 4 vs. 3). The two groups were comparable in terms of disease status, performance status, comorbidities, prior autologous SCT, type of donor, conditioning and in vivo T cell depletion. In multivariate analysis, pre‐allograft BV had no impact on acute graft‐versus‐host disease (GVHD), non‐relapse mortality, cumulative incidence of relapse, progression‐free survival or overall survival (OS), but significantly reduced the risk of chronic GVHD (hazard ratio = 0·64; 95% confidence interval = 0·45–0·92; P < 0·02). Older age, poor performance status, use of pre‐transplant radiotherapy and active disease at SCT adversely affected OS. Patients allografted for HL after prior exposure to BV do not have a superior outcome after allogeneic SCT except for a lower risk of chronic GVHD. However, BV may improve the outlook of allogeneic SCT by helping otherwise refractory patients to achieve a more favourable disease status, facilitating allotransplant success.
HER2 as a Therapeutic Target in Head and Neck Squamous Cell Carcinoma

The majority of patients with head and neck squamous cell carcinoma (HNSCC) present with advanced-stage disease. The current standard of care is surgery followed by adjuvant radiotherapy with or without chemotherapy or chemoradiation alone. The addition of cetuximab for the treatment of patients with locally advanced or recurrent/metastatic HNSCC has improved overall survival and locoregional control; however, responses are often modest, and treatment resistance is common. A variety of therapeutic strategies are being explored to overcome cetuximab resistance by blocking candidate proteins implicated in resistance mechanisms such as HER2. Several HER2 inhibitors are in clinical development for HNSCC, and HER2-targeted therapy has been approved for several cancers. This review focuses on the biology of HER2, its role in cancer development, and the rationale for clinical investigation of HER2 targeting in HNSCC. Clin Cancer Res; 21(3); 526–33. ©2014 AACR.
The role of biomimetism in developing nanostructured inorganic matrices for drug delivery

Background: Biomimetism of synthetic biomaterials can be carried out at different levels, such as composition, structure, morphology, bulk and surface chemical–physical properties. Biomaterials can be turned into biomimetic imprinting of all these characteristics in order not only to optimise their interaction with biological tissues, but also to mimic biogenic materials in their functionalities. Objective: This review outlines the biomimetic chemical–physical properties of inorganic matrices in controlling drug release. Methods: This review is restricted to phosphates and silica among inorganic biomaterials proposed as drug delivery vehicles. Conclusion: By mimicking nature, we can design and synthesise inorganic smart materials that are reactive towards biological tissues and can release bioactive molecules by a kinetic that is controlled not only by the matrix tailored chemical–physical properties, but also by the response to stimuli induced by physiological or pathological processes.
(Star-Based) three-valued Kripke-style semantics for pseudo- and weak-Boolean logics

This article investigates Kripke-style semantics for two sorts of logics: pseudo-Boolean (pB) and weak-Boolean (wB) logics. As examples of the first, we introduce G3 and S5 pB 3 . G3 is the three-valued Dummett–Gödel logic; S5 3 is the modal logic S5 but with its orthonegation replaced by a pB (or Heyting) negation. Examples of wB logic are GwB 3 and S5 wB 3 . G wB 3 is G3 with a wB negation in place of its pB negation; S5 wB 3 is S5 with a wB negation replacing its orthonegation. For each system, we provide a three-valued Kripke-style semantics with and without star operation (which is like the star operation of the Routley–Meyer semantics of relevance logics). We prove soundness and completeness theorems in each case. Note that wB logics may be equivalent to logics with Baaz’s projection . We finally introduce the G3 and the S5 pB 3 both with and show that they are equivalent to G wB 3 and S5wB 3 , respectively.
Association of Religious Service Attendance With Mortality Among Women.

IMPORTANCE Studies on the association between attendance at religious services and mortality often have been limited by inadequate methods for reverse causation, inability to assess effects over time, and limited information on mediators and cause-specific mortality. OBJECTIVE To evaluate associations between attendance at religious services and subsequent mortality in women. DESIGN, SETTING, AND PARTICIPANTS Attendance at religious services was assessed from the first questionnaire in 1992 through June 2012, by a self-reported question asked of 74 534 women in the Nurses' Health Study who were free of cardiovascular disease and cancer at baseline. Data analysis was conducted from return of the 1996 questionnaire through June 2012. MAIN OUTCOMES AND MEASURES Cox proportional hazards regression model and marginal structural models with time-varying covariates were used to examine the association of attendance at religious services with all-cause and cause-specific mortality. We adjusted for a wide range of demographic covariates, lifestyle factors, and medical history measured repeatedly during the follow-up, and performed sensitivity analyses to examine the influence of potential unmeasured and residual confounding. RESULTS Among the 74 534 women participants, there were 13 537 deaths, including 2721 owing to cardiovascular deaths and 4479 owing to cancer deaths. After multivariable adjustment for major lifestyle factors, risk factors, and attendance at religious services in 1992, attending a religious service more than once per week was associated with 33% lower all-cause mortality compared with women who had never attended religious services (hazard ratio, 0.67; 95% CI, 0.62-0.71; P < .001 for trend). Comparing women who attended religious services more than once per week with those who never attend, the hazard ratio for cardiovascular mortality was 0.73 (95% CI, 0.62-0.85; P < .001 for trend) and for cancer mortality was 0.79 (95% CI, 0.70-0.89; P < .001 for trend). Results were robust in sensitivity analysis. Depressive symptoms, smoking, social support, and optimism were potentially important mediators, although the overall proportion of the association between attendance at religious services and mortality was moderate (eg, social support explained 23% of the effect [P = .003], depressive symptoms explained 11% [P < .001], smoking explained 22% [P < .001], and optimism explained 9% [P < .001]). CONCLUSIONS AND RELEVANCE Frequent attendance at religious services was associated with significantly lower risk of all-cause, cardiovascular, and cancer mortality among women. Religion and spirituality may be an underappreciated resource that physicians could explore with their patients, as appropriate.
Polarized Infrared Study of Hybrid Langmuir−Blodgett Monolayers Containing Clay Mineral Nanoparticles

Hybrid clay-organic monolayers prepared using the Langmuir−Blodgett (LB) method are examined by polarized infrared attenuated total reflection spectroscopy (ATR), polarized grazing angle infrared reflection absorption spectroscopy (IRRAS), and atomic force microscopy (AFM). These spectra represent the first reported IR spectra of clay monolayers functionalized with cationic surfactants. The intensities of the ν(Si−O) bands of SapCa-1 saponite and SWy-1 montmorillonite on both Ge and ZnSe substrates were analyzed quantitatively using the thin film approximation. The measured intensity on both substrates corresponds to the calculated intensity of one clay layer (0.96 nm), indicating that a monolayer of clay was formed on ZnSe as well as on Ge. In the case of saponite, a trioctahedral smectite, the ν(OH) band at 3680 cm-1 and the out-of-plane ν(Si−O) band at 1063 cm-1 show dichroic ratios of 0.33 and 0.23, respectively, consistent with the nearly perpendicular orientation of these bonds in the film. For SWy-.
A 42nJ/conversion on-demand state-of-charge indicator for miniature IoT Li-ion batteries

An energy efficient State-of-Charge (SOC) indication algorithm and integrated system for small IoT batteries are introduced in this paper. The system is implemented in a 180-nm CMOS technology. Based on a key finding that small Li-ion batteries exhibit a linear dependence between battery voltage and load current, we propose an instantaneous linear extrapolation (ILE) algorithm and circuit allowing on-demand estimation of SOC. Power consumption is 42nW and maximum SOC indication error is 1.7%.
Localization of the Plasmodium falciparumPfNT1 Nucleoside Transporter to the Parasite Plasma Membrane*

Nutrient transporters play critical roles in parasite metabolism, but the membranes in which they reside have not been clearly defined. The transport of purine nutrients is crucial to the survival of the malaria parasite Plasmodium falciparum,and nucleoside transport activity has been associated with a number of different membrane components within the parasitized erythrocyte. To determine the location of the PfNT1 nucleoside transporter, the first component of the nucleoside permeation pathway to be studied at the molecular level in P. falciparum (Carter, N. S., Ben Mamoun, C., Liu, W., Silva, E. O., Landfear, S. M., Goldberg, D. E., and Ullman, B. (2000) J. Biol. Chem. 275, 10683–10691), polyclonal antisera against the NH2-terminal 36 amino acids of PfNT1 were raised in rabbits. Western blot analysis of parasite lysates revealed that the antibodies were specific for PfNT1 and that the level of PfNT1 protein in the infected erythrocyte is regulated in a stage-specific fashion. The amount of PfNT1 polypeptide increases dramatically during the early trophozoite stage and reaches its maximal level in the late trophozoite and schizont stages. Deconvolution and immunoelectron microscopy using these monospecific antibodies revealed that PfNT1 localizes predominantly, if not exclusively, to the plasma membrane of the parasite and not to the parasitophorous vacuolar or erythrocyte membranes.
Clinical adjudication in acute kidney injury studies: findings from the pivotal TIMP-2*IGFBP7 biomarker study

Background The NEPROCHECK test (Astute Medical, San Diego, CA, USA) combines urinary tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7) to identify patients at high risk for acute kidney injury (AKI). In a US Food and Drug Administration registration trial (NCT01573962), AKI was determined by a three-member clinical adjudication committee. The objectives were to examine agreement among adjudicators as well as between adjudicators and consensus criteria for AKI and to determine the relationship of biomarker concentrations and adjudicator agreement. Methods Subjects were classified as AKI 3/3, 2/3, 1/3 or 0/3 according to the proportion of adjudicators classifying the case as AKI. Subjects were classified as Kidney Disease: Improving Global Outcomes (KDIGO) AKI(+) when stage 2 or 3 AKI criteria were met. Results Concordance between adjudicators and between adjudicators and KDIGO criteria were lower for AKI than non-AKI subjects [78.9 versus 97.3% (P < 0.001) and 91.5 versus 97.9% (P = 0.01)]. Subjects who were AKI 3/3 or 2/3 but KDIGO AKI(−) had higher median [TIMP-2]•[IGFBP7] compared with those who were AKI-1/3 or 0/3 but KDIGO AKI(+) {2.78 [interquartile range (IQR) 2.33–3.56] versus 0.52 [IQR 0.26–1.64]; P = 0.008}. [TIMP-2]•[IGFBP7] levels were highest in patients with AKI 3/3 and lowest in AKI 0/3, whereas AKI 2/3 and 1/3 exhibited intermediate values. Conclusions In this analysis, urine [TIMP-2]•[IGFBP7] levels correlated to clinically adjudicated AKI better than to KDIGO criteria. Furthermore, in difficult cases where adjudicators overruled KDIGO criteria, the biomarker test discriminated well. This study highlights the importance of clinical adjudication of AKI for biomarker studies and lends further support for the value of urine [TIMP-2]•[IGFBP7].
Insect-Active Toxins with Promiscuous Pharmacology from the African Theraphosid Spider Monocentropus balfouri

Many chemical insecticides are becoming less efficacious due to rising resistance in pest species, which has created much interest in the development of new, eco-friendly bioinsecticides. Since insects are the primary prey of most spiders, their venoms are a rich source of insect-active peptides that can be used as leads for new bioinsecticides or as tools to study molecular receptors that are insecticidal targets. In the present study, we isolated two insecticidal peptides, µ/ω-TRTX-Mb1a and -Mb1b, from venom of the African tarantula Monocentropus balfouri. Recombinant µ/ω-TRTX-Mb1a and -Mb1b paralyzed both Lucilia cuprina (Australian sheep blowfly) and Musca domestica (housefly), but neither peptide affected larvae of Helicoverpa armigera (cotton bollworms). Both peptides inhibited currents mediated by voltage-gated sodium (NaV) and calcium channels in Periplaneta americana (American cockroach) dorsal unpaired median neurons, and they also inhibited the cloned Blattella germanica (German cockroach) NaV channel (BgNaV1). An additional effect seen only with Mb1a on BgNaV1 was a delay in fast inactivation. Comparison of the NaV channel sequences of the tested insect species revealed that variations in the S1–S2 loops in the voltage sensor domains might underlie the differences in activity between different phyla.
Performance of Children and Adolescents from a School of the City of Sogamoso on a Decision-Making Test

The aim of this study was to describe the performance on a decision-making task of children and adolescents (aged 7 - 17 years) from a school in the city of Sogamoso. This non-experimental descriptive, cross-sectional study was conducted by means of a non probability sampling of type cases. The sample consisted of 325 subjects, to whom the Hungry Donkey Task in its version adapted for Colombia was applied. Through descriptive statistics, the test performance trend was established, finding that participants aged 7 to 11 years had better performance than adolescents 12 to 14 years old, which partially supports the hypothesis of decision-making development in J shape. Subjects aged 15 to 17 years had the most disadvantageous performance, which may indicate immaturity and slow development of prefrontal areas and the influence of the trend towards risk-taking, characteristic of this age range.