Miracle-dz/UniFAR-FTUs huggingface dataset:
Pursuit Eye-Movements in Curve Driving Differentiate between Future Path and Tangent Point Models

For nearly 20 years, looking at the tangent point on the road edge has been prominent in models of visual orientation in curve driving. It is the most common interpretation of the commonly observed pattern of car drivers looking through a bend, or at the apex of the curve. Indeed, in the visual science literature, visual orientation towards the inside of a bend has become known as “tangent point orientation”. Yet, it remains to be empirically established whether it is the tangent point the drivers are looking at, or whether some other reference point on the road surface, or several reference points, are being targeted in addition to, or instead of, the tangent point. Recently discovered optokinetic pursuit eye-movements during curve driving can provide complementary evidence over and above traditional gaze-position measures. This paper presents the first detailed quantitative analysis of pursuit eye movements elicited by curvilinear optic flow in real driving. The data implicates the far zone beyond the tangent point as an important gaze target area during steady-state cornering. This is in line with the future path steering models, but difficult to reconcile with any pure tangent point steering model. We conclude that the tangent point steering models do not provide a general explanation of eye movement and steering during a curve driving sequence and cannot be considered uncritically as the default interpretation when the gaze position distribution is observed to be situated in the region of the curve apex.
Effect of the visual signal structure on Steady-State Visual Evoked Potentials detection

The detection of Steady-State Visual Evoked Potential (SSVEP) responses in the Electroencephalogram (EEG) is a current challenge in signal processing applied on Brain-Computer Interfaces (BCI). BCI based on SSVEP requires visual stimuli. When these stimuli are displayed on an LCD screen, the number of frequencies for flickering object on the screen is limited. We propose to extend the number of frequencies by composing different visual patterns. We evaluate the relationship in the frequency domain between the visual stimuli and the recorded EEG signal. The signal detection across seven types of SSVEP responses is achieved by considering spatial filters based on the generalized Rayleigh quotient. The mean detection accuracy across three subjects is 89.58%.
Genetic Epidemiological Perspective

Research on mapping diabetes-susceptibility genes is dependent on several factors, including the existence of a single major gene for susceptibility, genetic homogeneity, and the existence of appropriate clinical material. The power to detect susceptibility genes is dependent on the risks in relatives and the distance of genetic markers from the susceptibility genes. For insulin-dependent diabetes mellitus (IDDM), the bestfitting risk models are those with a single major locus with residual polygenic factors. The major locus effect is likely represented by genes in the HLA complex, because specific genotypes have been found to affect IDDM risk significantly. Thus, mapping the remaining polygenic IDDM susceptibility factors-each of small effect-is a difficult and long task. For non-insulindependent diabetes mellitus (NIDDM), the likely risk models result in few genes with moderate effect. Models of NlDDM have significant residual polygenic variation remaining, reflecting the importance of multiple loci with small effect, environmental effects, or genetic heterogeneity; however, the prospects for mapping genes that provide at least moderate susceptibility for NlDDM now appear promising. Diabetes 39:1315-19, 1990
Establishing the trochlear motor axon trajectory: role of the isthmic organiser and Fgf8

Formation of the trochlear nerve within the anterior hindbrain provides a model system to study a simple axonal projection within the vertebrate central nervous system. We show that trochlear motor neurons are born within the isthmic organiser and also immediately posterior to it in anterior rhombomere 1. Axons of the most anterior cells follow a dorsal projection, which circumnavigates the isthmus, while those of more posterior trochlear neurons project anterodorsally to enter the isthmus. Once within the isthmus, axons form large fascicles that extend to a dorsal exit point. We investigated the possibility that the projection of trochlear axons towards the isthmus and their subsequent growth within that tissue might depend upon chemoattraction. We demonstrate that both isthmic tissue and Fgf8 protein are attractants for trochlear axons in vitro, while ectopic Fgf8 causes turning of these axons away from their normal routes in vivo. Both inhibition of FGF receptor activation and inhibition of Fgf8 function in vitro affect formation of the trochlear projection within explants in a manner consistent with a guidance function of Fgf8 during trochlear axon navigation.
Evaluation of Catastrophe Models Using a Normalized Historical Record : Why it is needed and how to do it

Worldwide, the costs of natural disasters have increased dramatically in recent decades (Swiss Re 1997). Many in the insurance and reinsurance industries have noted this increase and simultaneously become aware that their exposure to catastrophic losses has been underestimated (Campbell 1997). One result of this greater attention to the risks of catastrophic loss has been the development over the last ten years of a consulting industry that provides predictive information based on sophisticated computer models on the probabilities and consequences of catastrophic events. These consultants — including firms such as Applied Insurance Research, EQECAT, Risk Management Solutions, and Tillinghast, as well as internal experts within large insurance firms — provide quantitative estimates of risk and exposure that inform a range of financial decisions.
Electric Propulsion of a Different Class: The Challenges of Testing for MegaWatt Missions

Currently, there is great interest in the development of high-power electric propulsion (EP) devices that can be employed in missions requiring >100 kW levels of propulsive power. Of the candidates for such thrusters, the Nested-channel Hall thruster (NHT) has been shown to be particularly scalable to this mission requirement. To this end, the University of Michigan’s Plasmadynamics and Electric Propulsion Laboratory (PEPL), in conjunction with both the Air Force Research Laboratory (AFRL) and NASA, has developed a 100-kW-class NHT called the X3. While bringing the X3 to test-ready status, a number of developmental and facility-related challenges were encountered and overcome. This paper presents these challenges and the lessons learned associated with the X3’s design, fabrication, and testing as a case study to inform other high-power EP development efforts.
Cognitive styles and search engine preferences: Field dependence/independence vs holism/serialism

Purpose – Cognitive style has been identified to be significantly influential in deciding users' preferences of search engines. In particular, Witkin's field dependence/independence has been widely studied in the area of web searching. It has been suggested that this cognitive style has conceptual links with the holism/serialism. This study aims to investigate the differences between the field dependence/independence and holism/serialism.Design/methodology/approach – An empirical study was conducted with 120 students from a UK university. Riding's cognitive style analysis (CSA) and Ford's study preference questionnaire (SPQ) were used to identify the students' cognitive styles. A questionnaire was designed to identify users' preferences for the design of search engines. Data mining techniques were applied to analyse the data obtained from the empirical study.Findings – The results highlight three findings. First, a fundamental link is confirmed between the two cognitive styles. Second, the relationship be.
Top-k Monitoring in Wireless Sensor Networks

Top-k monitoring is important to many wireless sensor applications. This paper exploits the semantics of top-k query and proposes an energy-efficient monitoring approach called FILA. The basic idea is to install a filter at each sensor node to suppress unnecessary sensor updates. Filter setting and query reevaluation upon updates are two fundamental issues to the correctness and efficiency of the FILA approach. We develop a query reevaluation algorithm that is capable of handling concurrent sensor updates. In particular, we present optimization techniques to reduce the probing cost. We design a skewed filter setting scheme, which aims to balance energy consumption and prolong network lifetime. Moreover, two filter update strategies, namely, eager and lazy, are proposed to favor different application scenarios. We also extend the algorithms to several variants of top-k query, that is, order-insensitive, approximate, and value monitoring. The performance of the proposed FILA approach is extensively evaluated using real data traces. The results show that FILA substantially outperforms the existing TAG-based approach and range caching approach in terms of both network lifetime and energy consumption under various network configurations.
Ghrelin Alleviates Neuropathic Pain Through GHSR-1a–Mediated Suppression of the p38 MAPK/NF-&kgr;B Pathway in a Rat Chronic Constriction Injury Model

Background and Objectives Neuropathic pain is related to the sustained activation of neuroglial cells and the production of proinflammatory cytokines in the spinal dorsal horn. Ghrelin, the endogenous ligand for growth hormone secretagogue receptor 1a (GHSR-1a), has been shown to inhibit the activation of microglia and the release of proinflammatory cytokines. The purpose of this study was to investigate the role of ghrelin/GHSR-1a signaling in neuropathic pain and to understand the associated mechanisms. Methods A rat model of neuropathic pain was established by chronic constriction injury (CCI) of the sciatic nerve. Hyperalgesia and allodynia were evaluated by observing the mechanical withdrawal threshold and the thermal withdrawal latency. The expression levels of ghrelin and GHSR-1a were detected by semiquantitative reverse transcriptase–polymerase chain reaction and Western blot analysis. The levels of interleukin-1&bgr; (IL-1&bgr;), IL-6, and tumor necrosis factor-&agr; were detected using an enzyme-linked immunosorbent assay. The expression levels of p-p38 mitogen-activated protein kinases (p38 MAPK) and nuclear factor-&kgr;B (NF-&kgr;B) p65 were determined by Western blot and immunohistochemistry analysis. Results Both ghrelin and GHSR-1a were expressed in the spinal dorsal horns of normal rats and were not significantly different from that of sham rats. However, rats in the CCI model group developed severe hyperalgesia and allodynia, as well as significantly downregulated expression of ghrelin and GHSR-1a. Compared with CCI model rats, intrathecal injection of ghrelin clearly delayed thermal hyperalgesia and mechanical allodynia at 3, 5, and 7 days after CCI; reduced the levels of IL-1&bgr;, IL-6, and tumor necrosis factor-&agr;; and inhibited the phosphorylation of p38 MAPK and the activation of NF-&kgr;Bp65 in the spinal dorsal horn. In addition, the effect of ghrelin could be blocked by [D-Lys3]-GHRP-6, a GHSR-1a antagonist. Conclusions Our present study demonstrated that ghrelin alleviated neuropathic pain through a GHSR-1a–mediated suppression of the p38 MAPK/NF-&kgr;B pathway.
Protease Inhibitors Extracted from Caesalpinia echinata Lam. Affect Kinin Release during Lung Inflammation

Inflammation is an essential process in many pulmonary diseases in which kinins are generated by protease action on kininogen, a phenomenon that is blocked by protease inhibitors. We evaluated kinin release in an in vivo lung inflammation model in rats, in the presence or absence of CeKI (C. echinata kallikrein inhibitor), a plasma kallikrein, cathepsin G, and proteinase-3 inhibitor, and rCeEI (recombinant C. echinata elastase inhibitor), which inhibits these proteases and also neutrophil elastase. Wistar rats were intravenously treated with buffer (negative control) or inhibitors and, subsequently, lipopolysaccharide was injected into their lungs. Blood, bronchoalveolar lavage fluid (BALF), and lung tissue were collected. In plasma, kinin release was higher in the LPS-treated animals in comparison to CeKI or rCeEI groups. rCeEI-treated animals presented less kinin than CeKI-treated group. Our data suggest that kinins play a pivotal role in lung inflammation and may be generated by different enzymes; however, neutrophil elastase seems to be the most important in the lung tissue context. These results open perspectives for a better understanding of biological process where neutrophil enzymes participate and indicate these plant inhibitors and their recombinant correlates for therapeutic trials involving pulmonary diseases.
Pituitary Adenylyl Cyclase-Activating Polypeptide Stimulates DNA Synthesis But Delays Maturation of Oligodendrocyte Progenitors

The neuropeptide pituitary adenylyl cyclase-activating peptide (PACAP) and one of its receptors (PAC1) are expressed in embryonic neural tube, where they appear to regulate neurogenesis and patterning. We now show that PAC1 gene expression is also present in neonatal rats in the ventricular and subventricular zones and in the optic chiasm, areas that are rich in oligodendrocyte (OL) progenitors (OLP). Because actions of PACAP on OLP have not been reported, we examined the effects of PACAP on the proliferation of purified OLP in culture and on myelinogenesis in cerebellar slices. Northern analyses on total RNA from purified glial cell subtypes revealed an abundant 7 kb hybridizing transcript in OLP, which was confirmed to correspond to the PAC1 receptor by reverse transcription-PCR. The presence of this receptor was also corroborated by radioligand binding and cAMP assay. In cultured OL, receptor density decreased during maturation but was partially counterbalanced by the appearance of sites that bound both PACAP and the related peptide vasoactive intestinal peptide. PACAP increased DNA synthesis in OLP cultures almost twofold and increased the bromodeoxyuridine-labeling index in O4-positive OLP. PACAP treatment also resulted in decreased sulfate incorporation into sulfatide in cultures of differentiating OL. The PACAP effect on sulfatide synthesis was fully reproduced in a cerebellar explant model. These findings indicate that PACAP may act at two stages during OL development to (1) stimulate proliferation and (2) delay maturation and/or myelinogenesis.
Modeling Colloid‐Facilitated Contaminant Transport in the Vadose Zone

Subsurface colloids can enhance the movement of strongly sorbing contaminants, a phenomenon called colloid‐facilitated contaminant transport. In the presence of mobile subsurface colloids, contaminants may move faster and farther than in the absence of colloids, thereby bypassing the filter and buffer capacity of soils and sediments. Fate and transport models neglecting colloid‐facilitated transport therefore often underpredict contaminant movement. Long‐term predictions of contaminant fate and transport as well as risk assessment rely on an accurate representation of subsurface processes, and in the case of strongly sorbing contaminants, need to consider mobile colloids as potential contaminant carriers. The purpose of this review is to discuss the current knowledge and recent developments of modeling colloid‐facilitated contaminant transport in the vadose zone. The main part of this review is devoted to the discussion of conceptual models used to describe colloid‐facilitated contaminant transport in the vadose zone and their mathematical implementation. Modeling of colloid‐facilitated contaminant transport involves various interactions, including colloid attachment to and detachment from the solid matrix and the air–water interface, contaminant adsorption to and desorption from colloids and transport with mobile colloids, and contaminant adsorption to and desorption from the solid matrix. Most of these processes in colloid‐facilitated contaminant transport models have been described by first‐ or second‐order kinetics. The unique feature of the vadose zone is the presence of an air phase, which affects colloid and contaminant transport in several ways. Colloids can be trapped in immobile water, strained in thin water films and in the smallest regions of the pore space, or attached to the air–water interface itself. The modeling of colloid‐facilitated contaminant transport in the vadose zone has mostly been theoretical, and tested only with column experiments; field applications are still lacking.
Artificial neural networks with adaptive multidimensional spline activation functions

This work concerns a new kind of neural structure that involves a multidimensional adaptive activation function. The proposed architecture, based on multidimensional cubic spline, allows to collect information from the previous network layer in aggregate form. In other words the number of network connections (structural complexity) can be very low respect to the problem complexity. This fact, as experimentally demonstrated in the paper, improve the network generalization capabilities and speed up the convergence of the learning process. A specific learning algorithm is derived and experimental results demonstrate the effectiveness of the proposed architecture.
New Millennium Antivirals against Pandemic and Epidemic Influenza: The Neuraminidase Inhibitors

The mushroom shaped outer spike protein of influenza, neuraminidase, was first discovered nearly 60 years ago. Its importance in viral replication was soon recognised both at the point of viral release from the cell and also enabling passage of virus through nasal fluid to reach the cell. The enzyme active site was identified by x-ray crystallography, allowing an atomic study of interaction of enzyme with the sialic acid substrate. Analogues could then be identified and synthesized and became a focused target for antivirals. With the current threat of bioterrorism and the potential for the emergence of a new pandemic strain in the near future, efforts are underway to develop more potent second-generation anti-neuraminidase inhibitors with enhanced protective and therapeutic effects. Here we review older and newer neuraminidase inhibitors and the role that they will play in the fight against influenza in its epidemic and pandemic face.
The use of synoptic climatology with general circulation model output over New Zealand

A cluster analysis‐based synoptic classification scheme, known as the Kidson types, was applied to reanalyses and Coupled Model Inter‐comparison Project phase 3 (CMIP3) general circulation model (GCM) output over New Zealand to identify the potential for future changes in regional circulation. Results indicate that a number of GCM 20th century control runs reproduce the type frequencies observed in reanalysis data. Application to future scenario runs for the periods 2046–2065 and 2081–2100 displays little variation in the annual frequency of the synoptic types relative to the 20th century, especially when uncertainty associated with the model ensemble is considered. This is surprising in the context of previous work on possible future movements in jet position and subsequent impacts on weather patterns. A sensitivity analysis that mimics the movement of the jet position was performed, revealing that the annual type frequencies are relatively insensitive to change. To determine whether this is a problem with the synoptic typing scheme, a correlation‐based classification technique was also used, but showed similar results. This work highlights issues with applying synoptic classification schemes to GCM output and indicates that if such schemes are to be used they should be designed and tested with this application in mind.
Desensitization of T lymphocyte function by CXCR3 ligands in human hepatocellular carcinoma.

AIM Despite the presence of lymphocyte infiltration, human hepatocellular carcinoma (HCC) is typically a rapidly progressive disease. The mechanism of regulation of lymphocyte migration is poorly understood. In this study, we investigated various factors regulating T cell migration in HCC patients. We examined serum CXC chemokine levels in HCC patients and demonstrated the production of CXC chemokines by HCC cell lines. We determined the effect of both HCC patient serum and tumor cell conditioned supernatant upon lymphocyte expression of chemokine receptor CXCR3 as well as lymphocyte migration. Lastly, we examined the chemotactic responses of lymphocytes derived from HCC patients. METHODS The serum chemokines IP-10 (CXCL10) and Mig (CXCL9) levels were measured by cytometric bead array (CBA) and the tumor tissue IP-10 concentration was measured by ELISA. The surface expression of CXCR3 on lymphocytes was determined by flow cytometry. The migratory function of lymphocytes to the corresponding chemokines was assessed using an in vitro chemotactic assay. Phosphorylation of extracellular signal-regulated kinase (ERK) was determined by Western blot analysis. RESULTS Increased levels of IP-10 and Mig were detected in HCC patient serum and culture supernatants of HCC cell lines. The IP-10 concentration in the tumor was significantly higher than that in the non-involved adjacent liver tissues. HCC cell lines secreted functional chemokines that induced a CXCR3-specific chemotactic response of lymphocytes. Furthermore, tumor-cell-derived chemokines induced initial rapid phosphorylation of lymphocyte ERK followed by later inhibition of ERK phosphorylation. The culture of normal lymphocytes with HCC cell line supernatants or medium containing serum from HCC patients resulted in a significant reduction in the proportion of lymphocytes exhibiting surface expression of CXCR3. The reduction in T cell expression of CXCR3 resulted in reduced migration toward the ligand IP-10, and both CD4+ and CD8+ T cells from HCC patients exhibited diminished chemotactic responses to IP-10 in vitro compared to T cells from healthy control subjects. CONCLUSION This study demonstrates functional desensitization of the chemokine receptor CXCR3 in lymphocytes from HCC patients by CXCR3 ligands secreted by tumor cells. This may cause lymphocyte dysfunction and subsequently impaired immune defense against the tumor.
Bioproduction of Chitooligosaccharides: Present and Perspectives

Chitin and chitosan oligosaccharides (COS) have been traditionally obtained by chemical digestion with strong acids. In light of the difficulties associated with these traditional production processes, environmentally compatible and reproducible production alternatives are desirable. Unlike chemical digestion, biodegradation of chitin and chitosan by enzymes or microorganisms does not require the use of toxic chemicals or excessive amounts of wastewater. Enzyme preparations with chitinase, chitosanase, and lysozymeare primarily used to hydrolyze chitin and chitosan. Commercial preparations of cellulase, protease, lipase, and pepsin provide another opportunity for oligosaccharide production. In addition to their hydrolytic activities, the transglycosylation activity of chitinolytic enzymes might be exploited for the synthesis of desired chitin oligomers and their derivatives. Chitin deacetylase is also potentially useful for the preparation of oligosaccharides. Recently, direct production of oligosaccharides from chitin and crab shells by a combination of mechanochemical grinding and enzymatic hydrolysis has been reported. Together with these, other emerging technologies such as direct degradation of chitin from crustacean shells and microbial cell walls, enzymatic synthesis of COS from small building blocks, and protein engineering technology for chitin-related enzymes have been discussed as the most significant challenge for industrial application.