Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of IL-4 on the Development and Function of Memory-like CD8 T Cells in the Peripheral Lymphoid Tissues

Unlike conventional T cells, innate CD8 T cells develop a memory-like phenotype in the thymus and immediately respond upon antigen stimulation, similar to memory T cells. The development of innate CD8 T cells in the thymus is known to require IL-4, which upregulates Eomesodermin (Eomes). These features are similar to that of virtual memory CD8 T cells and IL-4-induced memory-like CD8 T cells generated in the peripheral tissues. However, the relationship between these cell types has not been clearly documented. In the present study, IL-4-induced memory-like CD8 T cells generated in the peripheral tissues were compared with innate CD8 T cells in terms of phenotype and function. When an IL-4/anti-IL-4 antibody complex (IL-4C) was injected into C57BL/6 mice daily for 7 days, the EomeshiCXCR3 + CD8 T cell population was markedly increased in the peripheral lymphoid organs and blood. These cells were generated from naïve CD8 T cells or accumulated via the expansion of pre-existing CD44hiCXCR3 + CD8 T cells. Initially, the majority of these CXCR3 + CD8 T cells expressed low levels of CD44, which was followed by the conversion to the CD44hi phenotype. This conversion was associated with the acquisition of enhanced effector function. After discontinuation of IL-4C treatment, Eomes expression levels gradually decreased in CXCR3 + CD8 T cells. Taken together, the results of this study demonstrate that IL-4-induced memory-like CD8 T cells generated in the peripheral lymphoid tissues are phenotypically and functionally similar to the innate CD8 T cells generated in the thymus.
Performance Analysis of Classification Methods for Opinion Mining

Opinion mining extracts opinions expressed by a specified target from a set of documents. Opinion mining determines sentiment orientation positive, negative, or neutral of a (short) text and is a text understanding technology assisting people locate relevant opinions in a review collection of large volumes, quickly. A search engine based on opinion mining technology reveals potential to address the above dilemma. An opinion-mining tool extracts opinion units and saves them in an opinion database. The collection of ordered information through the opinion search engine is considered opinion based rather than document based one. Hence, product review information is easily accessed. Recently, opinion mining has received many attentions due to many forums, blogs, e-commerce web sites, news reports and additional web sources where people express opinions. Some opinion mining tasks try to classify detected opinion using various scales. The main objective of this method is opinion identification in a text and then to classify them as positive, negative or neutral. In this paper, it is proposed to extract the feature set based on IDF (Inverse Document Frequency) and classification models based on Naive Bayes, RIDOR and FURIA.
Detection of TP53 R249 Mutation in Iranian Patients with Pancreatic Cancer

The TP53 gene encodes tumor protein p53 which play a major role in the etiology of pancreatic cancer. The important role of codon 249 of TP53 for binding of p53 to its sequence-specific consensus site in DNA has been revealed by crystallography's studies, and mutation at this codon was detected in the plasma of some human cancers. The TP53 Mut assessor software within the International Agency for Research on Cancer (IARC) TP53 Database was performed to evaluate every possible mutation at codon 249. DNA was extracted from the plasma of 133 pancreatic cancer patients and 85 noncancer-bearing individuals. Exon 7 in TP53 was amplified, and mutation at R249 was identified by the endonuclease cleavage of HaeIII. The group of patients showed a frequency of 11% (22 of 133 samples) R249 mutation compared to 3.5% (3 of 85 samples) in the group of control which was significant (P = 0.03). This mutation demonstrated statistically significant association with pancreatic cancer risk in unadjusted odds ratio (OR: 3.74, 95% CI: 1.1–13.2; P = 0.041); however when adjusted for confounding factors, it was marginally significant because of lower control samples. These findings demonstrate that mutation at R249 of TP53 can be considered for increasing risk of pancreatic cancer that needs more research.
On translating geometric solids to functional expressions

Language for Structured Design (LSD)is a high level, visual, logic programming language for design of structured objects. LSD combines the design and programming activities in a homogeneous programming/design environment by extending Lograph, a visual logic programming language, with the notion of solids and operations on them. At the back-end, however, a solid modeling kernel for maintaining low level description of solids and operations is required.In this paper, we report on our progress towards employing PLaSM, a functional programming language for solid modeling, as the solid modeling kernel of LSD. This is achieved through the use of a translator engine which transforms the high level object description produced by LSD programs to PLaSM programs.
Human Age Estimation from Facial Images using Artificial Neural Network

Due to various potential applications and uses, research related to age estimation using face images has become important. Estimating age from still face images by using facial features is trending research topic from past few years. A lot of approaches and models came forward as the research progressed. Using features like high accuracy, faster processing and ability to learn, we have used Neural Network for this process rather than conventional one. For this purpose, we have used multi-layer perceptron neural network (MLP) which uses backpropagation algorithm. We primarily classify the ages in four groups and further classify into eight groups in secondary stage. We have used FGNET facial dataset for training and testing the network. Also we have collected our own real face dataset for the validation purpose. Keywords—Age Estimation, Aging Pattern, Active Appearance Model, Artificial Neural Networks, Backpropagation, Facial Features, Feature extraction, Singular Value Decomposition.
Formal and functional assessment of the pyramid method for summary content evaluation*

Abstract Pyramid annotation makes it possible to evaluate quantitatively and qualitatively the content of machine-generated (or human) summaries. Evaluation methods must prove themselves against the same measuring stick – evaluation – as other research methods. First, a formal assessment of pyramid data from the 2003 Document Understanding Conference (DUC) is presented; this addresses whether the form of annotation is reliable and whether score results are consistent across annotators. A combination of interannotator reliability measures of the two manual annotation phases (pyramid creation and annotation of system peer summaries against pyramid models), and significance tests of the similarity of system scores from distinct annotations, produces highly reliable results. The most rigorous test consists of a comparison of peer system rankings produced from two independent sets of pyramid and peer annotations, which produce essentially the same rankings. Three years of DUC data (2003, 2005, 2006) are used to assess the reliability of the method across distinct evaluation settings: distinct systems, document sets, summary lengths, and numbers of model summaries. This functional assessment addresses the method's ability to discriminate systems across years. Results indicate that the statistical power of the method is more than sufficient to identify statistically significant differences among systems, and that the statistical power varies little across the 3 years.
Experimental traffic sign detection using I2V communication

A traffic sign recognition (TSR) system is a driver assistance tool that automatically recognizes traffic signs placed along the road. Such a system can disburden the driver by this task and can significantly increase traffic safety, by warning the driver about them. This system is part of Advanced Driver Assistance Systems (ADAS), systems that have the goal to improve road safety. In this paper, we present an experimental system that uses an Infrastructure to Vehicles (I2V) communication for recognizing the traffic signs. Using the Radio Frequency Identification (RFID) technology, it identifies the traffic signals on the road and, through a Human Machine Interface (HMI), the system warns the driver about it.
Management of hyperglycemia in hospitalized patients in non-critical care setting: an endocrine society clinical practice guideline.

OBJECTIVE The aim was to formulate practice guidelines on the management of hyperglycemia in hospitalized patients in the non-critical care setting. PARTICIPANTS The Task Force was composed of a chair, selected by the Clinical Guidelines Subcommittee of The Endocrine Society, six additional experts, and a methodologist. EVIDENCE This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe both the strength of recommendations and the quality of evidence. CONSENSUS PROCESS One group meeting, several conference calls, and e-mail communications enabled consensus. Endocrine Society members, American Diabetes Association, American Heart Association, American Association of Diabetes Educators, European Society of Endocrinology, and the Society of Hospital Medicine reviewed and commented on preliminary drafts of this guideline. CONCLUSIONS Hyperglycemia is a common, serious, and costly health care problem in hospitalized patients. Observational and randomized controlled studies indicate that improvement in glycemic control results in lower rates of hospital complications in general medicine and surgery patients. Implementing a standardized sc insulin order set promoting the use of scheduled basal and nutritional insulin therapy is a key intervention in the inpatient management of diabetes. We provide recommendations for practical, achievable, and safe glycemic targets and describe protocols, procedures, and system improvements required to facilitate the achievement of glycemic goals in patients with hyperglycemia and diabetes admitted in non-critical care settings.
What's in a scent? Meaning, shape, and sensorial concepts elicited by scents

When selecting an ambient scent to be diffused in a store, one can focus on pleasantness of the scent, congruency of the scent with product category, or a variety of concepts that can be the basis for congruency between scent and other atmospheric elements. However, more information is needed concerning the concepts from which congruency could be sought. This paper studies the strength and direction of 19 bipolar concepts related to meaning, perceived shape and sensory attributes elicited by 32 scents. Factor analysis indicates that the concepts can be grouped into 4 factors: an angelic, an energetic, a shape, and a depth factor. Cluster analysis indicates that the 32 scents can be grouped based on differences in strength as well as direction of the elicitations. The results indicate that certain concepts do co-occur and that a classification of scents based on their similar elicitations of concepts might be of value.
Localization of Broca's and Wernicke's areas with resting state fMRI

Poster: "ECR 2016 / C-1673 / Localization of Broca's and Wernicke's areas with resting state fMRI" by: "L. Makovskaya, R. Vlasova, E. A. Mershina, E. Pechenkova ; Moscow/RU"
Ice elevations and surface change on the Malaspina Glacier, Alaska

Here we use Ice, Cloud and land Elevation Satellite (ICESat)‐derived elevations and surface characteristics to investigate the Malaspina Glacier of southern Alaska. Although there is significant elevation variability between ICESat tracks on this glacier, we were able to discern general patterns in surface elevation change by using a regional digital elevation model (DEM) as a reference surface. Specifically, we report elevation differences between ICESat Laser 1–3 observations (February 2003 – November 2004) and a Shuttle Radar Topography Mission (SRTM)‐derived DEM from February 2000. Elevation decreases of up to 20–25 m over a 3–4 year time period were observed across the folded loop moraine on the southern portion of the Malaspina Glacier.
Downlink macro-diversity with limited backhaul capacity

Multicell processing in the form of joint encoding for the downlink of a cellular system is studied under the realistic assumption that the base stations (BSs) are connected to a central unit via finitecapacity links (finite-capacity backhaul). Three scenarios are considered that present different tradeoffs between global processing at the central unit and local processing at the base stations and different requirements in terms of codebook information (CI) at the BSs: 1) local encoding with CI limited to a subset of nearby BSs; 2) mixed local and central encoding with only local CI; and 3) central encoding with oblivious cells (no CI). Three transmission strategies are proposed that provide achievable rates for the considered scenarios. Performance is evaluated in asymptotic regimes of interest (high backhaul capacity and extreme signal-to-noise ratio, SNR) and further corroborated by numerical results. The major finding of this work is that central encoding with oblivious cells is a very attractive option for both ease of implementation and performance, unless the application of interest requires high data rate (i.e., high SNR) and the backhaul capacity is not allowed to increase with the SNR, in which case some form of CI at the BSs becomes necessary.
Recent developments on the South American monsoon system

This paper reviews recent progress made in our understanding of the functioning and variability of the South American Monsoon System (SAMS) on time scales varying from synoptic to long‐term variability and climate change. The SAMS contains one of the most prominent summertime climate patterns in South America, featuring a strong seasonal variability in a region lying between the Amazon and the La Plata Basin. Much of the recent progress is derived from complementary international programs, such as the Monsoon Experiment South America (MESA), as well as from ongoing international programs such as the Large Scale Biosphere Atmosphere Experiment in the Amazon Basin (LBA) and the La Plata Basin (LPB) Regional Hydroclimate Project, which includes the CLARIS LPB Europe‐South America Network for Climate Change Assessment and Impact Studies in La Plata Basin Project. The latter assesses atmosphere‐land surface interactions, the role of land use changes and aerosols from biomass burning considered as sources of variability and change in the SAMS functioning, characteristics and behaviour.
Genetic Rearrangements of Six Wheat–Agropyron cristatum 6P Addition Lines Revealed by Molecular Markers

Agropyron cristatum (L.) Gaertn. (2n = 4x = 28, PPPP) not only is cultivated as pasture fodder but also could provide many desirable genes for wheat improvement. It is critical to obtain common wheat–A. cristatum alien disomic addition lines to locate the desired genes on the P genome chromosomes. Comparative analysis of the homoeologous relationships between the P genome chromosome and wheat genome chromosomes is a key step in transferring different desirable genes into common wheat and producing the desired alien translocation line while compensating for the loss of wheat chromatin. In this study, six common wheat–A. cristatum disomic addition lines were produced and analyzed by phenotypic examination, genomic in situ hybridization (GISH), SSR markers from the ABD genomes and STS markers from the P genome. Comparative maps, six in total, were generated and demonstrated that all six addition lines belonged to homoeologous group 6. However, chromosome 6P had undergone obvious rearrangements in different addition lines compared with the wheat chromosome, indicating that to obtain a genetic compensating alien translocation line, one should recombine alien chromosomal regions with homoeologous wheat chromosomes. Indeed, these addition lines were classified into four types based on the comparative mapping: 6PI, 6PII, 6PIII, and 6PIV. The different types of chromosome 6P possessed different desirable genes. For example, the 6PI type, containing three addition lines, carried genes conferring high numbers of kernels per spike and resistance to powdery mildew, important traits for wheat improvement. These results may prove valuable for promoting the development of conventional chromosome engineering techniques toward molecular chromosome engineering.
On the relaying area of contention-based geographic relay selection for cooperative wireless networks

Contention-based geographic relay selection for cooperative networks has been proposed as a state-free distributed scheme to efficiently select the best relay within a geographic area. The a priori choices for the relaying area cause different effects on the overall network performance. In this paper, we focus on the fundamental problem of predefining the relaying area and investigate its impact on the network performance. The previous work named CoopGeo, which is a cross-layer designed protocol including the relay and next hop selections, suggested the Reuleaux triangle as the relaying area, so as to avoid the hidden node problem in relay selection. However, it also leads to a certain loss of potential relays beneficial to the cooperation. Following the framework of CoopGeo, we develop a series of mathematical expressions for the relaying area, based on the average symbol error rate (SER) performance requirement. Further, the relaying area is derived and modeled as an ellipse-shaped region. Simulation results show that the CoopGeo using the proposed relaying area improves the network performance in terms of the delivery failure rate. The relaying area formulation and derivations provide a guideline regarding the design of the relaying area.
MISMATCH NEGATIVITY ( MMN ) AND N 330 IN THE ELDERLY

The application of event-related potentials (ERPs) to the study of human information processing has the advantage that subject’s responses can be evaluated even when they are not actively attending to the experimental task. The oddball paradigm, in which occasional deviant tones are interspersed among standard tones, enables the sensitivity of auditory memory to detect changes in stimuli to be studied. Subtracting the ERP to the standard tone from that for the deviant stimuli reveals an additional frontocentral component between 100 and 200 msec post-stimulus, which has been termed the mismatch negativity (MMN) (Näätänen, 1992, Näätänen & Ahlo, 1995). The amplitude and latency of the MMN can be modulated inter alia by increasing the degree of deviancy (frequency, intensity, duration) or by reducing the interstimulus interval (ISI). Winter et al. (1995) reported an additional component, the N330, which was more marked in the ERPs recorded while their young subjects slept. The present study is designed to extend on our previous findings by examining a group of older subjects. In addition, ISI will be varied to examine its interaction with age.
The study of the spread spectrum communication system based on sequence pairs

In this paper, a new definition of PN sequence - sequence pairs was introduced into the spread spectrum communication system. According to the PN sequence's technical requirements, this paper uses genetic algorithms to search hypo perfect sequence pairs between length 40 and length 50, and some results with better correlation function than Gold sequence are found. It also presents a new sequence pairs spread spectrum communication system, the system's performances are fundamentally studied in a simulated system and make a compare with Gold sequence spread spectrum communication system. The results prove that the performances of sequence pairs spread spectrum communication system are better than Gold sequence spread spectrum communication system in some ways.
Preliminary and real-time analysis of the time series invariant

Combination of search and analytical methods of the adaptive control in relation to PWM converters is considered in the paper. With this purpose it is proposed to use both real-time nonlinear dynamics forecasting and preliminary approximate expressions. Time series represents the main material for preliminary and current processing based on analysis of the regularities of nonlinear dynamics in the phase space.
Participation of Spanish older people in educational courses: The role of sociodemographic and active ageing factors

This study examines the factors associated with participation in educational courses among Spanish older people. Data were drawn from the Survey on Older People 2010, carried out by Spain’s National Institute of Older People and Social Services and based on a nationally representative sample. Overall, only 7.4 percent of the sample participated in an educational course. To analyse the factors related to this participation, we ran multivariate analyses using sociodemographic background data and participation in different kinds of active ageing activities. Gender, location, age, leisure activities, volunteering and political activity were found to be predictors of participation in educational courses. Leisure and productive activities showed greater predictive value for participation in educational courses than sociodemographic variables. In the light of the data, policies to promote older people’s participation in educational courses are discussed.
Neuropsychological and psychophysiological correlates of anger expression styles

The proposed research will investigate the effects of self-reported anger expression style on cerebrally lateralized physiological responses to a neuropsychological stressor and a painful stimulus. Specifically, this research will examine changes in systole and grip strength in response to a verbal fluency task, a figural fluency task and exposure to a cold pressor. Significant group by trial interaction effects were found for mean number of perseverative errors on neuropsychological measures (F(1,54) = 10.89, p < 0.05), systolic blood pressure following administration of a verbal fluency measure(F(1,54) = 5.86, p < 0.05), and non-verbal fluency measure (F(1,54) = 13.68, p<. 001), heart rate following administration of verbal (F(1,54) = 5.86, p < 0.05), and non verbal fluency measures (F(1,54) = 13.68, p<. 001), and grip strength following exposure to the cold pressor (F(1,54) = 13.69, p < 0.001). Results are discussed in terms of functional cerebral systems and potential implications for physiological models of anger.
The Mis-Measurement of Permanent Earnings: New Evidence from Social Security Earnings Data

This study investigates the reliability of using short-term averages of earnings as a proxy for permanent earnings in empirical research. An earnings dynamics model is estimated on a large sample of men covering the period from 1983 to 1997 following the cohort-based methodology of Baker and Solon (1999). The analysis uses a unique dataset that matches men in the 1984, 1990 and 1996 Surveys of Income and Program Participation (SIPP) to the Social Security Administration's Summary Earnings Records (SER). The results confirm that using a short-term average of earnings can lead to spurious estimates of the effect of lifetime earnings on a particular outcome. In addition, the transitory variance appears to vary considerably over the lifecycle. The share of earnings variance due to transitory factors is higher among blacks and the persistence of transitory shocks appears to be greater for this group as well. Finally, the transitory variance appears to be a more important factor in explaining the overall earnings variance of college educated men than those without college.