Miracle-dz/UniFAR-FTUs huggingface dataset:
FHY3 and FAR1 Act Downstream of Light Stable Phytochromes

FHY3 and FAR1 are positively acting transcription factors that directly regulate expression of a number of target genes in Arabidopsis thaliana. Here, we looked at the regulation of one specific target gene, ELF4. We demonstrate that the action of FHY3 and FAR1 in upregulation of ELF4 is light dependent. Furthermore, although FHY3 and FAR1 have been exclusively characterized as components of the phytochrome A signaling pathway because of their importance in regulating expression of phyA nuclear importers, we show that, as transcription factors in their own right, FHY3 and FAR1 act downstream of light stable phytochromes, phyB, phyD, and phyE. We demonstrate that light stable phytochrome acts in a red/far-red reversible manner to regulate the level of FHY3 protein. We also observed that ELF4 shows specific FHY3 and FAR1-mediated light induction in the evening and we show that regulation by light stable phytochromes at this time is important as it allows the plant to maintain normal ELF4 expression beyond dusk when the day length shortens, something which would not be possible through light labile phytochrome action. Without FHY3 and FAR1, ELF4 expression falls rapidly at dusk and in short days this results in an early drop in ELF4 expression, accompanied by a de-repression of an ELF4 target gene later in the night. Our results, therefore, demonstrate an important role for FHY3 and FAR1 as mediators of light stable phytochrome signaling.
Nurturing a Thriving Information Systems Discipline: A Call to Action

While the aspiration for the IS discipline's bright future is a shared objective, there is a controversy about what are the fundamental challenges ahead let alone how to approach them. This panel addresses the question of what should we do to nurture a thriving IS discipline? Opinions regarding how to solidify the position of the IS discipline can be classified into five interrelated clusters: research-oriented approaches, teaching-oriented approaches, practice-oriented approaches, scholarship-oriented approaches, and organization-oriented approaches. Building on crowdsourcing within the IS community to inform a panel of senior scholars, we will engage in a debate about possible approaches to nurture and invigorate the IS discipline in the coming decade. Overall, we aim to inspire and spark grassroots-based collective action in pursuit of thriving IS scholarship. At minimum, we hope to stimulate new insights about the desired and possible futures of the IS discipline, and the instrumental steps to realize them.
Randomized controlled trial of the haemodynamic and recovery effects of xenon or propofol anaesthesia.

BACKGROUND There is limited clinical experience with xenon in a large number of patients. We present intra- and postoperative haemodynamic and recovery data comparing xenon and total intravenous anaesthesia with propofol. METHODS A total of 160 patients aged 18-60 years (ASA I and II) undergoing elective surgery took part in this prospective non-blinded randomized controlled trial. After local ethics committee approval and written informed consent, patients were allocated randomly to either the xenon or the propofol group. Anaesthesia was induced with propofol and remifentanil and was maintained with xenon at 60% (minimal alveolar concentration 0.95) or with propofol 0.1-0.12 mg kg(-1) min(-1). Remifentanil was titrated to clinical need in both groups. RESULTS The two study groups were comparable with respect to age, weight, height, gender and ASA classification. Baseline in heart rate and systolic arterial pressure (SAP) were comparable in both groups. Following induction, SAP initially decreased but returned to baseline values over 15 min in the xenon group and differed significantly from the propofol group. Heart rate decreased significantly only in the xenon group and remained at stable values. Occurrence and duration of hypertension, hypotension and bradycardia showed no significant difference between groups. Patient recovery time in the post-anaesthetic care unit and recovery from anaesthesia was similar in the two groups. CONCLUSIONS After induction the xenon/opioid regimen maintains systolic blood pressure at baseline levels and a low heart rate. No differences between groups were found in haemodynamic stability during anaesthesia. Recovery from xenon anaesthesia was similar to that observed in the propofol group.
Named Entity Recognition for Question Answering

Current text-based question answering (QA) systems usually contain a named entity recogniser (NER) as a core component. Named entity recognition has traditionally been developed as a component for information extraction systems, and current techniques are focused on this end use. However, no formal assessment has been done on the characteristics of a NER within the task of question answering. In this paper we present a NER that aims at higher recall by allowing multiple entity labels to strings. The NER is embedded in a question answering system and the overall QA system performance is compared to that of one with a traditional variation of the NER that only allows single entity labels. It is shown that the added noise produced introduced by the additional labels is offset by the higher recall gained, therefore enabling the QA system to have a better chance to find the answer.
Wearable Computing : The future of computing

In past two decades desktop computing has establish ed itself as main way in which individuals use computers to run their businesses a nd solve problems that would otherwise have taken several man hours to solve. Re cently people have started to use small wearable computers such as PDAs and Cell phon es in their day to day activities. Wireless networks have started to enable people to be connected to each other from anywhere in the world and computing is heading towa rds scenario where by individuals will be able to carry with them a small portable co mputer with the power and functionality matching that of a desktop computer. This paper presents the state of current Wearable Computing hardware, software and outlines key technologies necessary for widespread adoption of Wearable Computing. Prototyp e wearable applications that were developed during the course of this investigation a re also presented. 1.
A Novel Approach to Improve Avalanche Effect of AES Algorithm

 Abstract— With the rapid progression of digital data exchange in electronic way, security of information is becoming more important in data storage and transmission. Therefore numerous ways of protecting information are being utilized by individuals, businesses, and governments. Cryptography has come up as a solution which plays a vital role in information security system against malicious attacks. This security system uses some algorithms to scramble data into scribbled text which can be only being decoded or decrypted by party those possesses the associated key. In this paper a most widely used symmetric encryption techniques i.e. advanced encryption standard (AES) have been implemented using MATLAB software. The primary goal of this paper is to improve level of security. The implemented encryption technique is analyzed by using a parameter called Avalanche effect. Plaintext and encryption key are mapped in binary code before encryption process. Avalanche Effect is calculated by changing one bit in plaintext keeping the key constant and by changing one bit in encryption key keeping the key constant, Experimental results shows that the proposed algorithm exhibit significant high Avalanche Effect which improves the level of the security.
A survey on web penetration test

This paper reviews the penetration test specifically in the field of web. For this purpose, it first reviews articles generally on penetration test and its associated methods. Then articles in the field of web penetration test are examined in three aspects: comparing automatic penetration test tools, introduction of new methods or tools for manual penetration test, and articles that presented a test environment for training or checking various instruments and methods. This article studied 4 different methodologies for web penetration test, 13 articles for comparing web vulnerability scanners, 10 articles that proposed a new method or tool for penetration test and 4 test environments.
Tolterodine to Relieve Urinary Symptoms Following Transurethral Resection of the Prostate: A Double-Blind Placebo-Controlled Randomized Clinical Trial

Purpose To evaluate the effect of tolterodine on early storage symptoms following transurethral resection of the prostate. Materials and Methods Seventy patients over 55 years of age who underwent transurethral resection of the prostate owing to benign prostatic hyperplasia were randomly assigned to receive either 2 mg of tolterodine twice daily (treatment group) or matched placebo during a 1-month study period. Before and 1 month after the procedure, they were asked to complete the International Prostate Symptom Score (IPSS) questionnaire and quality of life subscale to assess their symptoms. Also, analgesic use and adverse drug events were determined at follow-up. Results Of 70 allocated patients, 64 patients (91.4%), including 33 in the treatment group and 31 in the placebo group, completed the study. The mean age of the patients was 67 years. None of the patients' basic clinical characteristics were significantly different. At the end of the follow-up period, the total IPSS and quality of life score had significantly improved in the patients receiving tolterodine compared with those receiving placebo (p=0.001 and p=0.036, respectively). The treatment group compared with placebo demonstrated significant improvements in frequency and urgency but not in nocturia. The amount of consumed painkiller was also significantly lower in the tolterodine group than in the placebo group (p=0.0001). The rate of side effects was not significantly different between the groups. Conclusions Administering 2 mg of tolterodine twice daily is an effective and well-tolerated regimen to relieve early storage symptoms, quality of life, and the amount of analgesic consumption following transurethral resection of the prostate.
Cooperative Transmission and Radio Resources Management for Wireless Networks

For ideal stoppage of loom rotation at a constant crank angle, initiation of braking action on loom rotation is always automatically and properly timed on the basis of initial stop lag angle representative of the current braking function so that the resultant actual stop angle should match the preselected stop crank angle and, more preferably, the initial stop lag angle is renewed to cover gradual deterioration in the braking function.
DELISHUS: an efficient and exact algorithm for genome-wide detection of deletion polymorphism in autism

Motivation: The understanding of the genetic determinants of complex disease is undergoing a paradigm shift. Genetic heterogeneity of rare mutations with deleterious effects is more commonly being viewed as a major component of disease. Autism is an excellent example where research is active in identifying matches between the phenotypic and genomic heterogeneities. A considerable portion of autism appears to be correlated with copy number variation, which is not directly probed by single nucleotide polymorphism (SNP) array or sequencing technologies. Identifying the genetic heterogeneity of small deletions remains a major unresolved computational problem partly due to the inability of algorithms to detect them. Results: In this article, we present an algorithmic framework, which we term DELISHUS, that implements three exact algorithms for inferring regions of hemizygosity containing genomic deletions of all sizes and frequencies in SNP genotype data. We implement an efficient backtracking algorithm—that processes a 1 billion entry genome-wide association study SNP matrix in a few minutes—to compute all inherited deletions in a dataset. We further extend our model to give an efficient algorithm for detecting de novo deletions. Finally, given a set of called deletions, we also give a polynomial time algorithm for computing the critical regions of recurrent deletions. DELISHUS achieves significantly lower false-positive rates and higher power than previously published algorithms partly because it considers all individuals in the sample simultaneously. DELISHUS may be applied to SNP array or sequencing data to identify the deletion spectrum for family-based association studies. Availability: DELISHUS is available at http://www.brown.edu/Research/Istrail_Lab/. Contact: Eric_Morrow@brown.edu and Sorin_Istrail@brown.edu Supplementary information: Supplementary data are available at Bioinformatics online.
User characterization through network flow analysis

One of the objectives of network security is to control the use of shared resources among users. In this regard, knowing the actual identity of network users is quite valuable to the intermediate nodes. The dynamic allocation of IP addresses and Network Address Translation(NAT) make it practically difficult, without any significant modifications to end user protocols and applications, to identify users by looking at network traffic. This work tries to establish network flow analysis as a viable method of user identification in such cases. We propose a supervised learning model that uses flow features to identify users within a given set. Based on our analysis of flow features, we introduce the concept of flow-bundle-level features which can be derived from the packet-level and flow-level features which are generally recorded by flow probes. We have identified a set of flow-bundle-level features which is able to identify users with a high degree of accuracy. This set comprises two types of features, user-features which are characteristic of the behaviour of an individual user and host-features which are the properties of the user's host platform. We also present an argument that, with the increasing penetration of personal mobile devices, a one-host one-user is going to be the norm and hence inclusion of host features will strengthen the user identification model. The model was validated, with four different supervised learning algorithms, using a data-set of flow records of 65 users. It was able to give a highest accuracy of 83%.
Mechanical design optimization for multi-finger haptic devices applied to virtual grasping manipulation

This paper describes the design of a modular multi-finger haptic device for virtual object manipulation. Mechanical structures are based on one module per finger and can be scaled up to three fingers. Mechanical configurations for two and three fingers are based on the use of one and two redundant axes, respectively. As demonstrated, redundant axes significantly increase workspace and prevent link collisions, which is their main asset with respect to other multi-finger haptic devices. The location of redundant axes and link dimensions have been optimized in order to guarantee a proper workspace, manipulability, force capability, and inertia for the device. The mechanical haptic device design and a thimble adaptable to different finger sizes have also been developed for virtual object manipulation.
Validating the TDRT-Q to assess the quality of the teacher-dancer relationship

The capacity of coaches to enable or disable athletes’ engagement and ability to reach their potential through the quality of the relationship they develop with them has received substantial research attention, yet the equivalent dyad in dance contexts–the teacher-dancer relationship–has remained relatively unexplored. Thus, the purpose of this paper is to extrapolate Jowett’s 3C’s Coach-Athlete Relationship Model to the dance context and adapt and validate a Spanish translation of the CART-Q, a psychometric tool that has been extensively used to assess the coach-athlete relationship, to examine the teacher-dancer relationship. 175 Spanish dancers aged 18 to 40 (M = 22.47, SD = 4.85) of diverse performance levels and various dance disciplines completed the renamed Teacher-Dancer Relationship Questionnaire (TDRT-Q), the Spanish translation of the CART-Q adapted to dance contexts. A confirmatory factor analysis highlighted the hierarchical nature of the relationship as has been originally postulated containing Closeness, Commitment, and Complementarity. Overall the TDRT-Q demonstrated adequate psychometric properties. In line with these results, the 3C’s model can be transferred to analyse the teacher dancer relationship. Moreover, the TDRT-Q can be used to assess the quality of the teacher-dancer relationship and further advance knowledge and understanding in this achievement-orientated performing arts context.
A study on Smart-phone traffic analysis

The increase in Smart-phone users and expansion of market value creates traffic complexity and causes network saturation. Network technology lags development compared to the growth of traditional internet applications and Smart-phone based applications. Thus, the need for interest in network traffic monitoring increase. Traffic monitoring becomes an important element in the management of stable, efficient network. This paper analyzes various results of Smart-phone traffic in the campus network. It compares the characteristics and differences among traditional internet traffic and Smart-phone traffic.
TEMPERATE FOREST HEIGHT ESTIMATION PERFORMANCE USING ICESAT GLAS DATA FROM DIFFERENT OBSERVATION PERIODS

To investigate the forest height estimation potential and performance of different observation periods GLAS data in temperate region, this study uses the Northeast of China as test site. USFS FIA style field plots were collected. Two methods were used in this study to analyze different period data, i.e., i) the forest height analysis for those waveforms who have field measurements, ii) the near repeat observations analysis for those waveforms whose waveform center location is within 10 meters. The results show that the summer period GLAS waveforms capture the returns from forest canopy. The data from early stage of autumn period still contain enough returns from forest canopy, even with lower intensity. The spring period and late autumn period data contain less signals from forest canopy and difficult to estimate forest height. Further analysis will be carried out for all temperate forest areas and use appropriate periods data to generate forest height map for temperate forests. * Corresponding author: caf.pang@gmail.com
More control over network resources: An ISP caching perspective

Management operations performed by Content Delivery Network (CDN) providers consist mainly in controlling the placement of contents at different storage locations and deciding where to serve client requests from. Configuration decisions are usually taken by using only limited information about the carrier networks, and this can adversely affect network usage. In this work we propose an approach by which ISPs can have more control over their resources. This involves the deployment of caching points within their network, which can allow them to implement their own content placement strategies. The work presented in this paper investigates lightweight strategies that can be used by the ISPs to manage the placement of contents in the various network caching locations according to user demand characteristics. The proposed strategies differ in terms of the volume and nature of the information required to determine the new caching configurations. We evaluate the performance of the proposed strategies, in terms of network resource utilization, based on a wide range of user demand profiles and we compare the obtained performance according to metrics we define to characterize the demand. The results demonstrate that the proposed metrics can provide useful indications regarding the performance one strategy can achieve over another and, as such, can be used by the ISP to improve the utilization of network resources.
Experiences with the Alternate Reality Kit: An Example of the Tension between Literalism and Magic

This article presents an overview of the Alternate Reality Kit, an animated environment for creating interactive simulations. ARK is built upon a physical-world metaphor: All objects have an image, a position, a velocity, and the ability to experience forces. Users manipulate objects with a mouse-operated "hand," which enables them to carry and throw objects, press buttons, and operate sliders. The interface features are discussed in light of a general user interface tension between literalism and magic. Literal features¿defined as those that are true to the interface's metaphor¿enhance an interface's learnability. Magical features are defined as those capabilities that deliberately violate the metaphor in order to provide enhanced functionality. Discussion of each ARK feature includes informal observations of early ARK users, and an assessment of the feature's learnability, its usefulness, and its position on the magical-literal axis. Despite ARK's magical features, applications-level users have been trained in a few minutes. Although this article is about ARK, the tension between literalism and magic raises some interesting questions on its own. Some of these questions are presented briefly in the conclusion.
Electrodynamics of black hole magnetospheres

The main goal of this research is to get better insights into the properties of the plasma-filled magnetospheres of black holes by means of direct numerical simulations and, ultimately, to resolve the controversy surrounding the Blandford-Znajek mechanism. Driven by the need to write the equations of black hole electrodynamics in a form convenient for numerical applications, we constructed a new system of 3 + 1 equations, which not only has a more traditional form than the now classic 3 + 1 system of Thorne and Macdonald but also is more general. To deal with the magnetospheric current sheets, we also developed a simple model of radiative resistivity based on the inverse Compton scattering of background photons. The results of numerical simulations combined with simple analytical arguments allow us to make a number of important conclusions on the nature of the Blandford-Znajek mechanism. We show that, just like in the Penrose mechanism and in the magnetohydrodynamic models of Punsly and Coroniti, the key role in this mechanism is played by the black hole ergosphere. The poloidal currents are driven by the gravitationally induced electric field, which cannot be screened within the ergosphere by any static distribution of the electric charge of locally created pair plasma. Contrary to what is expected in the membrane paradigm, the energy and angular momentum are extracted not only along the magnetic field lines penetrating the event horizon but also along all field lines penetrating the ergosphere. In dipolar magnetic configurations symmetric relative to the equatorial plane, the force-free approximation breaks down within the ergosphere, where a strong current sheet develops along the equatorial plane. This current sheet supplies energy and angular momentum at infinity to the surrounding force-free magnetosphere. The Blandford-Znajek monopole solution is found to be asymptotically stable and causal. The so-called horizon boundary condition of Znajek is shown to be a regularity condition at fast critical surface.