Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficient reciprocating burrowing with anisotropic origami feet

Origami folding is an ancient art which holds promise for creating compliant and adaptable mechanisms, but has yet to be extensively studied for granular environments. At the same time, biological systems exploit anisotropic body forces for locomotion, such as the frictional anisotropy of a snake’s skin. In this work, we explore how foldable origami feet can be used to passively induce anisotropic force response in granular media, through varying their resistive plane. We present a reciprocating burrower which transfers pure symmetric linear motion into directed burrowing motion using a pair of deployable origami feet on either end. We also present an application of the reduced order model granular Resistive Force Theory to inform the design of deformable structures, and compare results with those from experiments and Discrete Element Method simulations. Through a single actuator, and without the use of advanced controllers or sensors, these origami feet enable burrowing locomotion. In this paper, we achieve burrowing translation ratios—net forward motion to overall linear actuation—over 46% by changing foot design without altering overall foot size. Specifically, anisotropic folding foot parameters should be tuned for optimal performance given a linear actuator’s stroke length.
The Socio-cultural Context of Barriers to Exclusive Breastfeeding Practices among Mothers in Karanganyar District Central Java Province

Background: Exclusive breastfeeding has an important role in preventing stunting among children due to chronic malnutrition. According to Indonesia Health Profile 2020, approximately 33.9% of children under six months were not exclusively breastfed. One of the challenges to achieving successful exclusive breastfeeding comes from socio-cultural aspects. Method: This mixed-methods study examined the socio-cultural context of barriers to exclusive breastfeeding among mothers. For a cross-sectional study in Karanganyar District, Central Java Province, a total of 706 participating mothers with children aged between 6–59 months were interviewed using a structured questionnaire in 2021. In addition, in-depth interviews with mothers were conducted to enrich the findings related to the obstacles in giving exclusive breastfeeding. Result: The binary logistic regression found that male children (AOR= 1.64, 95%CI (1.06, 2.56), children living in low-income households (AOR= 2.48, 1.25, 4.92), children with low-educated mothers (AOR= 8.84, 95%CI (3.83, 20.36), children with working mothers (AOR= 6.45, 95%CI (3.79, 10.98), children with pre lacteal feeding (AOR= 5.67, 95%CI (2.33, 13.75) were more likely to have nonexclusive breastfeeding. This study also revealed that 36,1% of mothers in Karanganyar District gave honey as pre-lacteal feeding to the newborn, which hindered exclusive breastfeeding practices. The qualitative approach also confirms this finding. Conclusion: Therefore, it is important to strengthen health promotion programs related to exclusive breastfeeding to mothers and the family through the life cycle approach based on the local context.
Improving the Production of Secondary Metabolites via the Application of Biogenic Zinc Oxide Nanoparticles in the Calli of Delonix elata: A Potential Medicinal Plant

The implementation of nanotechnology in the field of plant tissue culture has demonstrated an interesting impact on in vitro plant growth and development. Furthermore, the plant tissue culture accompanying nanoparticles has been showed to be a reliable alternative for the biosynthesis of secondary metabolites. Herein, the effectiveness of zinc oxide nanoparticles (ZnONPs) on the growth of Delonix elata calli, as well as their phytochemical profiles, were investigated. Delonix elata seeds were collected and germinated, and then the plant species was determined based on the PCR product sequence of ITS1 and ITS4 primers. Afterward, the calli derived from Delonix elata seedlings were subjected to 0, 10, 20, 30, 40, and 50 mg/L of ZnONPs. The ZnONPs were biologically synthesized using the Ricinus communis aqueous leaf extract, which acts as a capping and reducing agent, and zinc nitrate solution. The nanostructures of the biogenic ZnONPs were confirmed using different techniques like UV–visible spectroscopy (UV), zeta potential measurement, Fourier transform infrared spectra (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM). Adding 30 mg/L of ZnONPs to the MS media (containing 2.5 µM 2,4-D and 1 µM BAP) resulted in the highest callus fresh weight (5.65 g) compared to the control and other ZnONP treatments. Similarly, more phenolic accumulation (358.85 µg/g DW) and flavonoid (112.88 µg/g DW) contents were achieved at 30 mg/L. Furthermore, the high-performance liquid chromatography (HPLC) analysis showed significant increments in gallic acid, quercetin, hesperidin, and rutin in all treated ZnONP calli compared to the control. On the other hand, the gas chromatography and mass spectroscopy (GC-MS) analysis of the calli extracts revealed that nine phytochemical compounds were common among all extracts. Moreover, the most predominant compound found in calli treated with 20, 30, 40, and 50 mg/L of ZnONPs was bis(2-ethylhexyl) phthalate, with percentage areas of 27.33, 38.68, 22.66, and 17.98%, respectively. The predominant compounds in the control and in calli treated with 10 mg/L of ZnONPs were octadecanoic acid, 2-propenyl ester and heptanoic acid. In conclusion, in this study, green ZnONPs exerted beneficial effects on Delonix elata calli and improved their production of bioactive compounds, especially at a dose of 30 mg/L.
Some Important Properties of Multiple G-Itô Integral in the G-Expectation Space

In the G-expectation space, we propose the multiple Ito integral, which is driven by multi-dimensional G-Brownian motion. We prove the recursive relationship of multiple G-Ito integrals by G-Ito formula and mathematical induction, and we obtain some computational formulas for a kind of multiple G-Ito integrals.
The eddy-covariance method applied in a tethered-balloon

Turbulent processes of Atmospheric Boundary Layer contributes the most to transfers between the surface and the atmosphere. Typically turbulent boundary layer parameters are measured by sonic anemometer on masts and by research aircraft. To describe the evolution of the convective boundary layer between the surface and its top these two methods have several disadvantages, as for example, the elevation of the mast which is the greater part of the time less than 100 meters or the cost of deploying a research aircraft for a few hours of observation. This is to measure in-situ turbulent parameters in the Planetary Boundary Layer (PBL) at altitudes above 50 meters that our team have developed a system under tethered balloon since 2010. This system composed of a sonic anemometer and an inertial motion sensor has been validated during three campaigns, one dedicated and two of opportunity with different convective boundary layer conditions.
Nonlinear Analysis of Shape Memory Devices With Duffing and Quadratic Oscillators

In this paper, we investigate the linear and nonlinear response of shape memory alloy (SMA)-based Duffing and quadratic oscillator under large deflection conditions. In this study, we first present thermomechanical constitutive modeling of SMA with a single degree-of-freedom system. Subsequently, we solve equation to obtain linear frequency and nonlinear frequency response using the method of harmonic balance and validate it with numerical solution as well as averaging method under the isothermal condition. However, for nonisothermal condition, we analyze the influence of cubic and quadratic nonlinearity on nonlinear response based on method of harmonic balance. Analysis of results leads to various ways of controlling the nature and extent of nonlinear response of SMA-based oscillators. Such findings can be effectively used to control external vibration of different systems.
Height Fluctuations and Surface Gradients in Topographic Measurements

Topographic maps are composed of pixels associated with coordinates (x, y, z) on a surface. Each pixel location (x, y) is linked with fluctuations in a measured height sample (z). Fluctuations here are uncertainties in heights estimated from multiple topographic measurements at the same position. Height samples (z) are measured at individual locations (x, y) in topographic measurements and compared with gradients on topographies. Here, gradients are slopes on a surface calculated at the scale of the sampling interval from inclination angles of vectors that are normal to triangular facets formed by adjacent height samples (z = z(x, y)). Similarities between maps of gradients logs and height fluctuations are apparent. This shows that the fluctuations are exponentially dependent on local surface gradients. The highest fluctuations correspond to tool/material interactions for turned surfaces and to regions of maximum plastic deformation for sandblasted surfaces. Finally, for abraded, heterogeneous, multilayer surfaces, fluctuations are dependent on both abrasion and light/sub-layer interactions. It appears that the natures of irregular surface topographies govern fluctuation regimes, and that regions which are indicative of surface functionality, or integrity, can have the highest fluctuations.
Robin Approximation of Dirichlet Boundary Value Problems

ABSTRACT This paper describes the rate of convergence of solutions of Robin boundary value problems of an elliptic equation to the solution of a Dirichlet problem as a boundary parameter decreases to zero. The results are found using representations for solutions of the equations in terms of Steklov eigenfunctions. Particular interest is in the case where the Dirichlet data is only in L2(∂Ω,dσ). Various approximation bounds are obtained and the rate of convergence of the Robin approximations in the H1 and L2 norms are shown to have convergence rates that depend on the regularity of the Dirichlet data.
Narrowing the Relationship between Human CCR5 Gene Polymorphisms and Chagas Disease: Systematic Review and Meta-Analysis

Our aim was to carry out a qualitative and quantitative synthesis of the influence of CCR5 genetic variants on Chagas disease (CD) through a systematic review. A total of 1197 articles were analyzed, and eleven were included in the review. A meta-analysis was conducted along with principal component analyses (PCAs). The polymorphisms found were analyzed using the SNP2TFBS tool to identify possible variants that influence the interaction with gene binding sites. Eleven studied variants were identified: rs2856758, rs2734648, rs1799987, rs1799988, rs41469351, rs1800023, rs1800024, Δ32/rs333, rs3176763, rs3087253 and rs11575815. The studies analyzed were published between 2001 and 2019, conducted in Argentina, Brazil, Spain, Colombia and Venezuela, and included Argentine, Brazilian, Colombian, Peruvian and Venezuelan patients. Eight polymorphisms were subjected to the meta-analysis, of which six were associated with the development of the cardiac form of CD: rs1799987—G/G and G/A in the dominance model and G/G in the recessiveness model; rs2856758—A/G in the codominance model; rs2734648—T/T and T/G in the dominance model; rs1799988—T/T in both the codominance and recessiveness models; rs1800023—G allele and the G/G genotype in the codominance and recessiveness models, and the G/G and G/A genotypes in the dominance model; and rs1800024—T allele. The PCA analyses were able to indicate the relationships between the alleles and the genotypes of the polymorphisms. The SNP2TFBS tool identified rs1800023 as an influencer of the Spi1 transcription factor (p < 0.05). A correlation was established between the alleles associated with the cardiac form of CD in this review, members of the C haplotype of the gene (HHC–TGTG), and the cardiac form of CD.
In vitro cross-talk between metastasis-competent circulating tumor cells and platelets in colon cancer: a malicious association during the harsh journey in the blood

Background: Platelets are active players in hemostasis, coagulation and also tumorigenesis. The cross-talk between platelets and circulating tumor cells (CTCs) may have various pro-cancer effects, including promoting tumor growth, epithelial-mesenchymal transition (EMT), metastatic cell survival, adhesion, arrest and also pre-metastatic niche and metastasis formation. Interaction with CTCs might alter the platelet transcriptome. However, as CTCs are rare events, the cross-talk between CTCs and platelets is poorly understood. Here, we used our established colon CTC lines to investigate the colon CTC-platelet cross-talk in vitro and its impact on the behavior/phenotype of both cell types. Methods: We exposed platelets isolated from healthy donors to thrombin (positive control) or to conditioned medium from three CTC lines from one patient with colon cancer and then we monitored the morphological and protein expression changes by microscopy and flow cytometry. We then analyzed the transcriptome by RNA-sequencing of platelets indirectly (presence of a Transwell insert) co-cultured with the three CTC lines. We also quantified by reverse transcription-quantitative PCR the expression of genes related to EMT and cancer development in CTCs after direct co-culture (no Transwell insert) with platelets. Results: We observed morphological and transcriptomic changes in platelets upon exposure to CTC conditioned medium and indirect co-culture (secretome). Moreover, the expression levels of genes involved in EMT (p < 0.05) were decreased in CTCs co-cultured with platelets, but not of genes encoding mesenchymal markers (FN1 and SNAI2). The expression levels of genes involved in cancer invasiveness (MYC, VEGFB, IL33, PTGS2, and PTGER2) were increased. Conclusion: For the first time, we studied the CTC-platelet cross-talk using our unique colon CTC lines. Incubation with CTC conditioned medium led to platelet aggregation and activation, supporting the hypothesis that their interaction may contribute to preserve CTC integrity during their journey in the bloodstream. Moreover, co-culture with platelets influenced the expression of several genes involved in invasiveness and EMT maintenance in CTCs.
Using a Standing Heel-Rise Test as a Predictor of Ankle Muscle Strength in the Elderly

The senior population is at increased risk of falling due to a reduction in ankle muscle strength. Evaluating the strength of the ankle muscles in older adults is of paramount importance. The purpose of this study was to formulate an equation to estimate ankle muscle strength by utilizing the basic physical characteristics of the subject and the variables related to their ability to perform the standing heel-rise test (SHRT). One hundred and thirty-two healthy elderly participants (mean age 67.30 ± 7.60) completed the SHRT and provided demographic information. Ankle plantar flexor (PF) muscle strength was evaluated using a push–pull dynamometer. Multiple regression analysis was utilized to develop a prediction equation for ankle PF muscle strength. The study revealed that the ankle PF strength equation was derived from variables including the power index of the SHRT, gender, age, calf circumference, and single-leg standing balance test. The equation exhibited a strong correlation (r = 0.816) and had a predictive power of 65.3%. The equation is represented as follows: ankle PF strength = 24.31 − 0.20(A) + 8.14(G) + 0.49(CC) + 0.07(SSEO) + 0.20(BW/t-SHRT). The equation had an estimation error of 5.51 kg. The strength of ankle PFs in elderly individuals can be estimated by considering demographic variables, including gender, age, calf circumference, single-leg standing balance test, and the power index of the SHRT. These factors were identified as significant determinants of ankle PF strength in this population.
Guided self-study in preclinical physiotherapy students – A feasibility study

Background Literature describing the impact of guided self-study (G-SS) in knowledge changes and skills improvements in undergraduate students is scarce. Objectives The aims of our study were to evaluate the feasibility of a G-SS programme in a full-time undergraduate physiotherapy degree course and to assess the effectiveness of the G-SS on changes in knowledge and development of skills (hands-on). Method Fifty-three first-semester undergraduate physiotherapy students were randomly divided into a G-SS group and a control group (CG). The G-SS group received six clinical cases and prepared each case during an 8-day cycle. The control group received self-study learning units of the original curriculum content. Primary outcome parameters were (1) time of task, (2) responsiveness of students and (3) programme differentiation. Knowledge changes and skills changes were tested using a multiple-choice questionnaire and the objective structured clinical examination (OSCE). Results Students’ responsiveness was 32%. This was below the a priori set 83%. No differences in programme differentiation were found. The OSCE grade was significantly higher in the G-SS compared to CG (p = 0.003). Conclusion The G-SS programme in its current form was not feasible regarding students’ responsiveness. Therefore, a slight modification of our study protocol (e.g., better time planning in the academic calendar) is needed to improve students’ willingness to participate in the G-SS programme. Clinical implications Adaptation of the school timetable should allow undergraduate physiotherapy students to prepare clinical cases under conditions of lower workload. Guided self-study as compared to CG is superior in knowledge change and (hands-on) skills improvement.
Why are grammatical elements more evenly dispersed than lexical elements? Assessing the roles of text frequency and semantic generality

Grammatical elements such as determiners, conjunctions or pronouns are very evenly dispersed across natural language data. By contrast, the uses of lexical elements have a stronger tendency to occur in bursts that are interspersed by long lulls. This paper considers two alternative explanations for this difference. First, it could be hypothesised that the more even distribution of grammatical elements is merely an effect of an element's high text frequency. Alternatively, it could be argued that a more even distribution is a symptom of greater generality in meaning. In order to assess the impact of both frequency and semantic generality, we conducted a corpus-based study that contrasts lexical and grammatical elements in Present-Day English. Our results suggest that evenness of dispersion is chiefly an effect of high frequency.
Using SOFIA for Stellar Physics Studies

Abstract The Stratospheric Observatory for Infrared Astronomy (SOFIA) operates in the 0.3–240 micron wavelength region, and offers imaging, polarimetric and high-resolution spectroscopic capabilities that can be used for a wide range of observations relevant for stellar physics studies. We summarize the advantages of using SOFIA, list some of the studies related to stellar physics that have been accomplished, and provide an example high-resolution spectrum of a red supergiant.
Novel Mutation Glu98Lys in Cardiac Tropomyosin Alters Its Structure and Impairs Myocardial Relaxation

We characterized a novel genetic variant c.292G > A (p.E98K) in the TPM1 gene encoding cardiac tropomyosin 1.1 isoform (Tpm1.1), found in a proband with a phenotype of complex cardiomyopathy with conduction dysfunction and slow progressive neuromuscular involvement. To understand the molecular mechanism by which this mutation impairs cardiac function, we produced recombinant Tpm1.1 carrying an E98K substitution and studied how this substitution affects the structure of the Tpm1.1 molecule and its functional properties. The results showed that the E98K substitution in the N-terminal part of the Tpm molecule significantly destabilizes the C-terminal part of Tpm, thus indicating a long-distance destabilizing effect of the substitution on the Tpm coiled-coil structure. The E98K substitution did not noticeably affect Tpm’s affinity for F-actin but significantly impaired Tpm’s regulatory properties. It increased the Ca2+ sensitivity of the sliding velocity of regulated thin filaments over cardiac myosin in an in vitro motility assay and caused an incomplete block of the thin filament sliding at low Ca2+ concentrations. The incomplete motility block in the absence of Ca2+ can be explained by the loosening of the Tpm interaction with troponin I (TnI), thus increasing Tpm mobility on the surface of an actin filament that partially unlocks the myosin binding sites. This hypothesis is supported by the molecular dynamics (MD) simulation that showed that the E98 Tpm residue is involved in hydrogen bonding with the C-terminal part of TnI. Thus, the results allowed us to explain the mechanism by which the E98K Tpm mutation impairs sarcomeric function and myocardial relaxation.
Vanishing discount approximations in controlled Markov chains with risk-sensitive average criterion

Abstract This work concerns Markov decision chains on a finite state space. The decision-maker has a constant and nonnull risk sensitivity coefficient, and the performance of a control policy is measured by two different indices, namely, the discounted and average criteria. Motivated by well-known results for the risk-neutral case, the problem of approximating the optimal risk-sensitive average cost in terms of the optimal risk-sensitive discounted value functions is addressed. Under suitable communication assumptions, it is shown that, as the discount factor increases to 1, appropriate normalizations of the optimal discounted value functions converge to the optimal average cost, and to the functional part of the solution of the risk-sensitive average cost optimality equation.
Design of a memory-access controller with 3.71-times-enhanced energy efficiency for Internet-of-Things-oriented nonvolatile microcontroller unit

In realizing a nonvolatile microcontroller unit (MCU) for sensor nodes in Internet-of-Things (IoT) applications, it is important to solve the data-transfer bottleneck between the central processing unit (CPU) and the nonvolatile memory constituting the MCU. As one circuit-oriented approach to solving this problem, we propose a memory access minimization technique for magnetoresistive-random-access-memory (MRAM)-embedded nonvolatile MCUs. In addition to multiplexing and prefetching of memory access, the proposed technique realizes efficient instruction fetch by eliminating redundant memory access while considering the code length of the instruction to be fetched and the transition of the memory address to be accessed. As a result, the performance of the MCU can be improved while relaxing the performance requirement for the embedded MRAM, and compact and low-power implementation can be performed as compared with the conventional cache-based one. Through the evaluation using a system consisting of a general purpose 32-bit CPU and embedded MRAM, it is demonstrated that the proposed technique increases the peak efficiency of the system up to 3.71 times, while a 2.29-fold area reduction is achieved compared with the cache-based one.