Miracle-dz/UniFAR-FTUs huggingface dataset:
Activation of glucocorticoid receptor signaling inhibits KSHV-induced inflammation and tumorigenesis

Hyperinflammation is the hallmark of Kaposi’s sarcoma (KS), the most common cancer in AIDS patients caused by Kaposi’s sarcoma-associated herpesvirus (KSHV) infection. However, the role and mechanism of induction of inflammation in KS remain unclear. In a screening for inhibitors of KSHV-induced oncogenesis, over half of the identified candidates were anti-inflammatory agents including dexamethasone functions by activating glucocorticoid receptor (GR) signaling. Here, we examined the mechanism mediating KSHV-induced inflammation. We found that numerous inflammatory pathways were activated in KSHV-transformed cells. Particularly, interleukin-1 alpha (IL-1α) and IL-1 receptor antagonist (IL-1Ra) from the IL-1 family were the most induced and suppressed cytokines, respectively. We found that KSHV miRNAs mediated IL-1α induction while both miRNAs and vFLIP mediated IL-1Ra suppression. Furthermore, GR signaling was inhibited in KSHV-transformed cells, which was mediated by vFLIP and vCyclin. Dexamethasone treatment activated GR signaling, and inhibited cell proliferation and colony formation in soft agar of KSHV-transformed cells but had a minimal effect on matched primary cells. Consequently, dexamethasone suppressed the initiation and growth of KSHV-induced tumors in mice. Mechanistically, dexamethasone suppressed IL-1α but induced IL-1Ra expression. Treatment with recombinant IL-1α protein rescued the inhibitory effect of dexamethasone while overexpression of IL-1Ra caused a weak growth inhibition of KSHV-transformed cells. Furthermore, dexamethasone induced IκBα expression resulting in inhibition of NF-κB pathway and IL-1α expression. These results reveal an important role of IL-1 pathway in KSHV-induced inflammation and oncogenesis, which can be inhibited by dexamethasone-activated GR signaling, and identify IL-1-mediated inflammation as a potential therapeutic target for KSHV-induced malignancies. Importance Kaposi’s sarcoma (KS) is the most common cancer in HIV-infected patients caused by Kaposi’s sarcoma-associated herpesvirus (KSHV) infection. Hyperinflammation is the hallmark of KS. In this study, we have shown that KSHV mediates hyperinflammation by inducing IL-1α and suppressing IL-1Ra. Mechanistically, KSHV miRNAs and vFLIP induce hyperinflammation by activating the NF-κB pathway. A common anti-inflammatory agent dexamethasone blocks KSHV-induced hyperinflammation and tumorigenesis by activating glucocorticoid receptor signaling to suppress IL-1α and induce IL-1Ra. This work has identified IL-1-mediated inflammation as a potential therapeutic target and dexamethasone as a potential therapeutic agent for KSHV-induced malignancies.
Colour polymorphism and conspicuousness do not increase speciation rates in Lacertids

Conspicuous body colours and colour polymorphism have been hypothesized to increase rates of speciation. Conspicuous colours are evolutionary labile, and often involved in intraspecific sexual signalling and thus may provide a raw material from which reproductive isolation can easily evolve, while polymorphism could favour rapid evolution of new lineages through morphic speciation. Here, we investigated the influence of the presence/absence of conspicuous colourations, and of colour polymorphism on the speciation of Lacertids. We used several state-dependent diversification models, and showed that, regardless of the methods, conspicuous colourations and colour polymorphism were not related to species speciation. While the lack of correlation between conspicuous colourations and speciation rates is in line with most of the literature testing this hypothesis, the results for colour polymorphism contradict previous studies, and question the generality of the morphic speciation hypothesis.
Association Between Action Video Game Playing Experience and Visual Search in Real-world Multisensory scenes

Prior studies investigating the effects of playing action video games have demonstrated improvements in a variety of basic psychophysical tasks, including attentional control. However, as of yet, there is little evidence indicating that the cognitive benefits of playing action video games generalize to naturalistic multisensory scenes – a fundamental characteristic of our natural, everyday life environments. In particular, it is unknown whether video-game experience may have an impact on cross-modal congruence effects in such naturalistic contexts. The present study addressed the generalization of attentional control enhancement due to action video-game experience to real-life scenarios by comparing the performance of action video-game players (AVGPs) with non-players (NVGPs) on a visual search task in video clips containing naturalistic audio-visual scenes. A gender-balanced sample of N=60 (30 per group), was recruited online via a questionnaire on gaming habits, and run the visual search task. According to the standard hypothesis, AVGPs outperformed NVGPs in the search task overall, showing faster reaction times without sacrificing accuracy. In addition, in replication of previous findings, semantically congruent cross-modal cues benefited performance, compared to neutral or incongruent ones. However, according to our results, despite the overall advantage in search, and the multisensory congruence benefit, AVGPs did not exploit multisensory cues more efficiently than NVGPs. Exploratory analyses with gender as a variable indicated that the generalization of the advantage of AVG experience to both genders should be done with caution.
Adding Organizations and Roles as Primitives to JADE Framework

The organization metaphor is often used in the design and imple- mentation of multiagent systems. However, few agent programming languages provide facilities to define them. Several frameworks are proposed to coordinate MAS with organizations, but they are not programmable with general purpose languages. In this paper we extend the JADE framework with primitives to pro- gram in Java organizations structured in roles and to enable agents to play roles in organizations. Roles facilitate the coordination of agents inside an organiza- tion and give new abilities in the context of organizations, called powers, to the agents which satisfy the requirements necessary to play the roles. As primitives to program organizations and roles we provide classes and protocols which enable an agent to enact a new role in an organization and to interact with the role by invoking the execution of powers, and to receive new goals to be fulfilled. Roles have state and behaviour, thus, they are instances of classes and are strictly con- nected with the organization offering them. Since roles and organizations can be on a different platform with respect to the role player, the communication with them happens via protocols. Moreover, since, besides using protocols, roles and organizations can have complex behaviours, they are implemented by extending the JADE agent class.
Identification of the association between HMMR expression and progression of hepatocellular carcinoma via construction of a co-expression network

The aim of the present study was to identify key genes involved in the progression of hepatocellular carcinoma (HCC). According to the theory of the multistep process of hepatocarcinogenesis and weighted gene co-expression network analysis, hub genes associated with the progression of HCC were identified using the gene expression profiles of patients with normal to chronic hepatitis/cirrhosis and dysplastic nodules to HCC. An independent dataset was used to verify the association between hub gene and clinical phenotype. The diagnostic and prognostic value of hub genes regarding HCC were evaluated. Gene set enrichment analysis (GSEA) was performed to explore the function of hub genes. A co-expression gene module positively associated with HCC progression was identified. Combined with a protein-protein interaction (PPI) network, a total of 10 common hub genes common to both the module of interest and the PPI network were selected as hub genes. Hyaluronan mediated motility receptor (HMMR) was selected as the candidate gene and was significantly upregulated in HCC at the mRNA and protein expression levels. HMMR is a promising diagnostic biomarker for HCC, and is also associated with its progression. The expression of HMMR was positively correlated with HCC tumor grade, pathological stage, tumor stage and Ishak score. The expression of HMMR was an independent prognostic factor compared with clinicopathological features. Patients with high expression levels of HMMR exhibited a less favorable prognosis. GSEA identified 6 representative gene sets that were associated with cancer. Overall, HMMR may serve an important role in HCC and may have potential as a biomarker of HCC diagnosis and progression.
Beetles and fuelwood harvesting: a retrospective study from Tasmania's southern forests.

Coarse woody debris (CWD) is a key component of forest ecosystems, ultimately supporting perhaps the majority of forestdependent species. In many parts of the world, forestry practices that diminish CWD have been shown to impact heavily on saproxylic (CWDdependent) species. Plans for wood-fired power stations as a part of integrated wood-processing facilities being developed in Tasmania give cause for concern because it is CWD that will be harvested as fuelwood. This paper outlines a study undertaken to help understand the potential impacts of fuelwood harvesting on biodiversity. Two pairs of study sites in the southern forests were sampled for saproxylic beetles in summer 2004/05. All sites supported regenerating forest following harvesting in the 1980s. One member of each pair of sites had been harvested by conventional clearfell, burn and sow (CBS) silviculture, while the other member of each pair had additionally been subjected to fuelwood harvesting (CBS-FW) which resulted in lower levels of retained CWD. Trends in species richness with treatment were inconsistent, but lowered overall beetle abundance in CBS-FW compared to CBS, and differences in assemblage composition at the coupe level, strongly suggested an impact of fuelwood harvesting over and above that of CBS. In general, trends were clearer among obligately saproxylic species than among facultatively saproxylic species, while nonsaproxylic species either showed a weaker trend, no trend or a trend in the opposite direction to the saproxylic species. These findings agree
Use of Purified Laccase from Prickly Lettuce ( Lactuca serriola L.) In Removal of Phenolic Compound from Some Foods

: Laccase from Prickly lettuce leaves was purified through three sequential steps using (NH 4 ) 2 SO 4 , ion-exchange and gel filtration chromatography. At the end of the process, enzyme was 17.04 fold purification and yield of 76.66% with a specific activity 141.996 U/mg. The molecular weight was 69.37 kDa as estimated by gel filtration chromatography (Sephacryl S-200). The visible absorption spectrum showed one peak at 618 nm that is typical for type I Cu (II). The optimum pH activity was 6 and enzyme was stable between 4-7, while temperature activity was 40 and enzyme was stable at 60°C for 15 min. Carbohydrate content of purified laccase was 12% as determined by phenol sulfuric acid, and enzyme was 100% inhibited by 10mM of Sodium azide, l-cysteine, dithiothreitol and EDTA and 98, 96, 94, 91, 93 and 82% by SDS, Hg +2 , Al +2 , Ba +2 , Ni +2 and Mn +2 respectively at same concentration, while inhibition at 1Mm was 45, 39, 62, 59, 51, 53, 48, 55 and 41% respectively, and the Km and Vmax values was 53.68 μM and 641.2 μM\min respectively. The treatment of apple juice with 1, 5, 10, 20 u\mg of laccase led to removed 11.35, 44.72, 88.03 and 89.21 % of phenol compounds respectively, while the treated with 10 u\mg of laccase for 10, 20, 30, 40, 50, 60 min led to removed 28.42, 60.93, 88.03, 89.37, 90.01 and 90.04% of phenol compounds respectively.
Co-producing a research agenda for sustainable palm oil

Padfield, Rory, Hansen, Sune, Davies, Zoe G. , Ehrensperger, Albrecht, Slade, Eleanor M. , Evers, Stephanie, Papargyropoulou, Effie, Bessou, Cécile, Abdullah, Norhayati, Page, Susan, Ancrenaz, Marc, Aplin, Paul, Dzulkafli, Shahirah Balqis, Barclay, Holly, Chellaiah, Darshanaa, Choudhary, Sonal, Conway, Samantha, Cook, Sarah, Copeland, Alison, Campos-Arceiz, Ahimsa, Deere, Nicolas J., Drew, Simon, Gilvear, David, Gray, Ross, Haller, Tobias, Hood, Amelia S-C. , Huat, Lee Kim, Huynh, Nhat, Kangayatkarasu, Nagulendran, Koh, Lian Pin, Kolandai, Sanath Kumaran, Lim, Robin Ah Hee, Yeong, Kok Loong, Lucey, Jennifer M. , Luke, Sarah H. , Mitchell, Simon L. , Montefrio, Marvin J., Mullin, Katherine, Nainar, Anand, Nekaris, K. Anne-Isola, Nijman, Vincent, Nunes, Matheus, Nurhidayu, Siti, O'Reilly, Patrick, Puan, Chong Leong, Ruppert, Nadine, Salim, Hengky, Schouten, Greetje, Tallontire, Anne, Smith, Thomas E. L. , Tao, Hsiao-Hang, Tham, Mun Hou, Varkkey, Helena, Wadey, Jamie, Yule, Catherine M. , Azhar, Badrul, Sayok, Alexander K. , Vairappan, Charles, Bicknell, Jake E. and Struebig, Matthew J. (2019) Coproducing a research agenda for sustainable palm oil. Frontiers in Forests and Global Change, 2. p. 13. ISSN 2624-893X
Comparison of Machining Performance of Ti-6Al-4V under Dry and Cryogenic Techniques Based on Tool Wear, Surface Roughness, and Power Consumption

The machining of Ti-6Al-4V alloys is challenging due to their high strength, poor thermal conductivity, and high chemical reactivity. When used in traditional machining, cryogenic coolants can reduce tool wear, thus extending tool life, improving surface finish, and requiring less power with reduced environmental effects. In this context, this study aimed to perform a machinability analysis of the surface roughness, power consumption, tool wear, and specific energy consumption of a Ti-6Al-4V titanium alloy and to comprehend the performance of dry and cryogenic machining in turning operations. A comprehensive analysis of tool wear and specific cutting energy (SCE) under dry and cryogenic machining was conducted. It was found that the machining time under a cryogenic environment was increased by 83% and 39% at 80 and 90 m/min compared to a cutting speed at 100 m/min. The higher cutting speed (100 m/min) in cryogenic environments produced an improved surface finish. Compared to dry machining, the cooling effect of liquid CO2 helped dissipate heat and reduce thermal damage, improving surface finish. The findings revealed that in dry conditions, approximately 5.55%, 26.45%, and 27.61% less power was consumed than in cryogenic conditions at 80, 90, and 100 m/min cutting speeds, respectively. Based on the outcomes of the work, the application of cryogenic cooling can be considered an alternative to dry and flood cooling for improving the machinability of Ti-6Al-4V alloys.
Nanoparticle-Based Approaches for Treatment of Hematological Malignancies: a Comprehensive Review

Blood cancer, also known as hematological malignancy, is one of the devastating types of cancer that has significantly paved its mortality mark globally. It persists as an extremely deadly cancer type and needs utmost attention owing to its negligible overall survival rate. Major challenges in the treatment of blood cancer include difficulties in early diagnosis, as well as severe side effects resulting from chemotherapy. In addition, immunotherapies and targeted therapies can be prohibitively expensive. Over the past two decades, scientists have devised a few nanoparticle-based drug delivery systems aimed at overcoming this challenge. These therapeutic strategies are engineered to augment the cellular uptake, pharmacokinetics, and effectiveness of anticancer drugs. However, there are still numerous types of nanoparticles that could potentially improve the efficacy of blood cancer treatment, while also reducing treatment costs and mitigating drug-related side effects. To the best of our knowledge, there has been limited reviews published on the use of nano-based drug delivery systems for the treatment of hematological malignancies. Therefore, we have made a concerted effort to provide a comprehensive review that draws upon recent literature and patents, with a focus on the most promising results regarding the use of nanoparticle-based approaches for the treatment of hematological malignancies. All these crucial points covered under a common title would significantly help researchers and scientists working in the area.
Aqua Incognita: the unknown headwaters

Running water comprises just over one millionth of the world’s water.The importance of those streams and rivers as a resource for humanwelfare and biodiversity, however, is far out of proportion to thatminuscule fraction. This explains why protecting running waters (theﬂow regimes, water quality and biota) is such a vital concern for society.Yet for all the focus and concern, how much do we actually know aboutthese running waters, and the lotic habitat they comprise? Consider what would happen if one asked any national environmentalauthority to assess the basic chemical and ecological status of runningwaters. At the river mouths, there would be enough information tomake a reasonable assessment of the status. But somewhere on theway upstream, available data would run dry, long before most streamchannels did (in non-arid regions). In Sweden, with an ambitious programme for monitoring and assess-ing surface waters, it came as a surprise several years ago to realizethat the length of all perennial streams on the country’s maps was notknown. When that was modelled in the form of a ‘virtual network’ froma50m
Optimizing Privacy-Accuracy Trade-off in DP-FL via Significant Gradient Perturbation

—In federated learning with differential privacy, an obvious phenomenon of local gradient sparsity emerges in some training rounds. When training with low privacy budgets, there is a risk of excessive noise being added to the uploaded gradients, leading to a significant decrease in the accuracy of the global model. To tackle the trade-off between privacy protection and model accuracy with low privacy budgets, we propose a differential privacy federated aggregation method based on gradient sparsity (DP-FedAGS), which not only prevents excessive noise addition by protecting only significant gradients, but also accelerates global model convergence by dynamically calculating the weight of the gradient. Experimental results indicate that DP-FedAGS achieves comparable privacy protection to DP-FedAvg and cpSGD, while outperforming DP-FedSNLC. Moreover, our approach respectively attains an approximate average test accuracy improvement of 2 . 45% , 4 . 79% , and 0 . 29% over the above three methods, rendering DP-FedAGS a promising approach for exploring a balance between privacy protection and model accuracy.
Effect of Nursing Intervention for Chemotherapy Induced Nausea and Vomiting among Breast Cancer Women

: Nursing intervention of chemotherapy therapy induced nausea and vomiting as complementary care considered safe, noninvasive, and generally free from side effect. The aim of this study was to identify the effectiveness of nursing intervention on reducing chemotherapy induced nausea and vomiting among breast cancer women. Methods: Design: A quasi experimental pre-post-test design was used to evaluate the effectiveness of nursing intervention for chemotherapy induced nausea and vomiting among breast cancer women. Subjects: A convenience sample of 150 women with breast cancer. women were selected from the out-patient clinics at Oncology Institute, Menoufia University, Egypt. Instruments: (1) Structured interview questionnaire schedule to assess socio demographic data, medical data , knowledge about the disease process and nursing intervention. Tool (2): Functional Assessment of Cancer Therapy General Population. It compromised of four dimensions were assessed: physical wellbeing, social well-being, emotional well-being, and functional well-being pre and post nursing intervention. Results: It was illustrated that, regarding the total physical wellbeing was (7.8%, 6.36% respectively), the total social wellbeing was (13.20%, 14.61% respectively), the total emotional wellbeing was (9.2% , 6.7% respectively) and, The total functional wellbeing was (6.45%, 9.9% respectively) post intervention among the studied group. There were statistically significant differences between the study groups pre and post nursing intervention regarding knowledge and practices among pre and post nursing intervention. where p-value were ≤ 0.0001. Conclusions: the study concluded that application of nursing intervention proved to be effective in improving the four dimensions and knowledge regarding chemotherapy therapy induced nausea and vomiting among breast cancer women. Recommendation: Application of nursing intervention of chemotherapy-induced nausea and vomiting as a complementary therapy should be carried out at different setting and different types of cancer.
A Boiler-Thrbine System Control Using a Fuzzy Auto-Regressive Moving Average (FARMA) Model

This paper presents an application of an online self-organizing fuzzy-logic controller to a boiler-turbine system of a fossil power plant. The control rules and the membership functions of the proposed fuzzy logic controller are generated automatically without using plant model. A boiler-turbine system is described as a multi-input multi-output (MIMO) nonlinear system in this paper. Three single-loop fuzzy-logic controllers are designed independently. Simulation shows robust results for various kinds of electric load demand changes and parameter variations of boiler-turbine system.
Performance of microfinance institutions in Europe-Does social capital matter?1

This paper investigates performance drivers of microfinance suppliers in Europe. As these, in contrast to advanced microfinance suppliers in developing economies, typically focus on uncollateralized microcredit services to individuals at the margin of society and of labour markets, we draw on the theory of social capital and empirically investigate the role that social capital may play in the overall performance of European microfinance suppliers. We build a unique unbalanced panel data set of 302 microfinance service providers in Europe covering the years 2008 to 2015 and measure their performance in terms of credit risk, financial and social performance as well as efficiency. Pursuing an econometric approach, we test a series of hypotheses using various measures of conditions conducive for building social capital on both institution-specific and country level, such as the client base of a microfinance supplier and the level of cultural fractionalization in a society. Our findings confirm that a higher intensity of social capital is positively associated with all areas of performance of microfinance suppliers in Europe. Our conclusions could help in designing and launching microfinance institutions in those European countries in which microfinance markets are developed not at all or to a very limited extent. Our paper, thus, contributes to the nascent literature on microfinance in developed economies by applying and extending the theoretical framework and empirical models on social capital and microfinance that were originally elaborated for developing countries.