Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficient Warranty-Aware Wear Leveling for Embedded Systems With PCM Main Memory

Recently, phase change memory (PCM) has become a promising candidate to replace dynamic RAM as main memory due to its low power consumption, fast I/O performance, and byte addressability. Accompanied with the merits, the adoption of PCM may suffer from its physical characteristic of limited write endurance. Wear leveling is a well-known approach to address this issue. For PCM main memory, the design of wear leveling should stress operation efficiency and overhead reduction. Nevertheless, conventional designs are usually dedicated to prolonging the lifetime of PCM in the best effort. In this paper, we propose a novel perspective that, instead of valuing PCM lifetime exploitation as the first priority, we turn to satisfy the product warranty period. With such a paradigm shift, the management overhead of wear-leveling mechanisms could be reduced so as to achieve further enhancement of operation efficiency. To this end, we propose a warranty-aware page management design that introduces novel criteria used to determine the state of a page by taking both the product warranty period and the write cycles of a page into consideration. Theoretical analysis is also conducted to investigate the properties and performance of the proposed management. To show the effectiveness of the proposed design, we collected real traces by running SPEC2006 benchmarks with different write intensity workloads. The experimental results showed that our design reduced the overhead to one-third that of the state-of-the-art designs while still providing the same level of performance.
Prevalence of Von Willebrand Disease in Dogs from São Paulo State, Brazil

The aims of the current study were to assess the prevalence of von Willebrand disease (vWD) in dogs from the region of Botucatu, São Paulo State, Brazil, and to evaluate laboratory tests to diagnose this disease. The study included 350 dogs of various ages, different breeds, and both sexes. Dogs included in the study had no historical or clinical evidence of abnormal bleeding. von Willebrand factor antigen (vWF: Ag), buccal mucosal bleeding time, activated partial thromboplastin time, and factor VIII activity were evaluated in their ability to diagnose vWD. The prevalence of vWD in dogs was 1.43% in the Botucatu region of Brazil. Determination of vWF: Ag was the best laboratory test to diagnose vWD.
Managing Unsolicited Ideas for R&D

Existing academic and popular literature suggests that unsolicited ideas, the non-contractual and voluntary submission of innovation-related information from external sources to the firm, offer the promise of a bountiful and low-cost tool to sustain and extend firms' R&D efforts. Yet, in practice, many organizations find it difficult to deal with unsolicited ideas because of high quantity, low quality, and the need to transfer IP ownership. This article identifies a range of practices that allow organizations to meet these challenges and therefore realize some of the potential of unsolicited ideas for R&D.
Fc gamma RI blockade and modulation for immunotherapy.

Splenectomy and corticosteroids are the treatment of choice for patients with immune thrombocytopenic purpura (ITP). However, for the 10%-15% of patients who do not respond to conventional therapy, high-dose i.v. IgG can induce life-saving transient responses. The benefits of i.v. IgG have been attributed to Fc receptor blockade; however, the involvement of the individual Fc receptors for IgG (Fc gamma R) in ITP remain to be more completely defined. Recently a mAb, designated mAb H22, which recognizes an epitope on Fc gamma RI (CD64) outside the ligand-binding domain, was humanized. Because mAb H22 is a human IgG1 and Fc gamma RI has a high affinity for human IgG1 antibodies, we predicted that mAb H22 would bind to the Fc gamma RI ligand-binding site through its Fc domain and to its external Fc gamma RI epitope through both Fab domains. These studies demonstrate that mAb H22 blocked Fc gamma RI-mediated phagocytosis of opsonized red blood cells more effectively than an irrelevant IgG. Moreover, cross-linking Fc gamma RI with mAb H22 down-modulated Fc gamma RI expression on monocytes, an effect seen within 2 h.
Analytical model of carbon storage in the trees, soils, and wood products of managed forests.

The carbon balance between managed forests and the atmosphere depends critically on the frequency and intensity of harvesting, and the lifetime of harvested products. To assess more quantitatively the nature of this dependence, a theoretical analysis, previously applied to carbon storage in trees and wood products only, is extended here to include the carbon in forest floor detritus and soil. A dimensionless combination of the parameters of the model, alpha, with critical value alpha(c), is identified such that for alpha < alpha(c), the conversion of old-growth forest to managed forest releases carbon to the atmosphere in the long term. Parameter alpha is given by the combination f(t)D/T(*), where f(t) is the fraction of old-growth forest carbon stored in trees, D is the residence time of harvested biomass (wood products and slash debris) within the system, and T(*) is the rotation period for maximum sustained yield (maximum mean annual increment). The critical value alpha(c), typically in the range 0.5-0.7, is derived for a variety of forest types. Parameter alpha determines the degree to which the carbon accumulated in harvested biomass offsets the loss of carbon in trees due to felling and in soils due to reduced litter input. When alpha > alpha(c), long-term carbon storage is optimized by harvesting for maximum sustained yield.
RADIATION EXPOSURE DURING ENDOVASCULAR PROCEDURES

OBJECTIVE The duration of fluoroscopy exposure is routinely recorded as part of endovascular procedures. However, to better relate the duration of exposure to actual doses of surface and intracranial radiation, we compared surface doses during endovascular procedures with intracranial doses in a cadaver model exposed to lateral fluoroscopy. METHODS Optically stimulated luminescence dosimeter chips (Landauer, Glenwood, IL) were used to measure the cranial surface dose of three consecutive patients undergoing endovascular procedures. Bitemporal craniotomies were performed on a cadaver. Dosimeter chips were placed on both the ipsilateral and contralateral skin and meningeal surfaces, and the cadaver was exposed to lateral fluoroscopy. Finally, to assess mean fluoroscopy times in patients undergoing embolization procedures, the operative notes of 100 consecutive patients were reviewed. RESULTS Three patients undergoing endovascular treatment received peak doses of 0.24, 0.31, and 1.38 Gy, respectively. In the cadaver, the peak surface dose recorded after 120 minutes of exposure was 1.71 Gy. The cranium and scalp absorbed or reflected 29% of the surface dose. Time in minutes of fluoroscopy was found to correlate with surface dose (R2 = 0.925). CONCLUSION Our data show that radiation exposure during endovascular treatment can reach clinically significant levels. The surface doses recorded during this study were comparable to the mean dose of 1.5 Gy estimated by others to increase the relative risk of inducing meningiomas, gliomas, and nerve sheath tumors. Pending long-term follow-up of patients exposed to endovascular procedures, consent for possible long-term sequelae of radiation may be warranted.
Gene Cluster Involved in the Biosynthesis of Griseobactin, a Catechol-Peptide Siderophore of Streptomyces sp. ATCC 700974

ABSTRACT The main siderophores produced by streptomycetes are desferrioxamines. Here we show that Streptomyces sp. ATCC 700974 and several Streptomyces griseus strains, in addition, synthesize a hitherto unknown siderophore with a catechol-peptide structure, named griseobactin. The production is repressed by iron. We sequenced a 26-kb DNA region comprising a siderophore biosynthetic gene cluster encoding proteins similar to DhbABCEFG, which are involved in the biosynthesis of 2,3-dihydroxybenzoate (DHBA) and in the incorporation of DHBA into siderophores via a nonribosomal peptide synthetase. Adjacent to the biosynthesis genes are genes that encode proteins for the secretion, uptake, and degradation of siderophores. To correlate the gene cluster with griseobactin synthesis, the dhb genes in ATCC 700974 were disrupted. The resulting mutants no longer synthesized DHBA and griseobactin; production of both was restored by complementation with the dhb genes. Heterologous expression of the dhb genes or of the entire griseobactin biosynthesis gene cluster in the catechol-negative strain Streptomyces lividans TK23 resulted in the synthesis and secretion of DHBA or griseobactin, respectively, suggesting that these genes are sufficient for DHBA and griseobactin biosynthesis. Griseobactin was purified and characterized; its structure is consistent with a cyclic and, to a lesser extent, linear form of the trimeric ester of 2,3-dihydroxybenzoyl-arginyl-threonine complexed with aluminum under iron-limiting conditions. This is the first report identifying the gene cluster for the biosynthesis of DHBA and a catechol siderophore in Streptomyces.
EFNS guidelines on diagnosis and treatment of primary dystonias

EFNS guidelines on diagnosis and treatment of primary dystonias A. Albanese, F. Asmus, K. P. Bhatia, A. E. Elia, B. Elibol, G. Filippini, T. Gasser, J. K. Krauss, N. Nardocci, A. Newton and J. Valls-Solé Istituto Neurologico Carlo Besta, Milan, Italy; Università Cattolica del Sacro Cuore, Milan, Italy; Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research, University of Tubingen, Germany; Institute of Neurology, University College London, Queen Square, London, UK; Hacettepe University Hospitals, Department of Neurology, Ankara, Turkey; Department of Neurosurgery, Medical School Hannover, MHH, Hannover, Germany; European Dystonia Federation, Brussels, Belgium; and Neurology Department, Hospital Clı́nic, Barcelona, Spain
Protection of acid-base balance by pH regulation of acid production.

Under normal physiologic conditions, acid–base balance is maintained by renal excretion of hydrogen ions generated during the metabolism of dietary protein and other metabolic processes. In normal subjects, these so-called fixed acids are produced at an average rate of approximately 1 mmol per kilogram of body weight, or 50 to 70 mmol per day, with a variety of organic acids accounting for half this amount and sulfuric and phosphoric acids for the remainder. When a disturbance in systemic pH occurs as the result of an excess or loss of acid or base, shifts in body buffers and ventilatory adjustment of .
Changes in the Jaw Relationships during Human Foetal Cranio-facial Growth

Previous investigations into pre-natal cranio-facial growth have either been purely descriptive or have involved the use of cephalometric points, lines and angles. Neither methods have given an entirely clear picture of the changes taking place during the foetal period. The present investigation measured changes in shape, position and orientation of the jaws by using image outlines and their centroids (centres of area) in combination with the analytic method of morphanalysis. The image outlines of the foetuses were related to each other via a rectangular co-ordinate reference grid so that the exact sites where growth changes occurred could be plotted and isolated. It was found that the jaw relationships were constantly changing during the foetal period. Brain growth appeared to predominate which flattened out the cranial base and determined the definitive position of the naso-maxillary segment to which the musculature of the lower face in turn adjusted mandibular growth. The jaw relationships changed in the direction Class Ill to Class 11 mainly as a result of forward growth of the naso-maxillary segment, the mandible showing a lag followed by a catch-up regaining its original position. The two jaws exhibited different growth patterns which suggested differences in the underlying mechanisms responsible for their growth. This is almost certainly an important factor in the aetiology of malocclusion resulting from malrelationships of the basal bones and soft tissues.
Buying into Community Supported Agriculture: Strategies for Overcoming Income Barriers

ABSTRACT Community-supported agriculture provides benefits to members, including improved nutrition, economic savings, increased food security, and knowledge about the source of one's food. Unfortunately, membership may seem out of reach for limited-resource consumers because a lump sum membership fee is generally required at the beginning of the season. This article examines the strategies being used by CSA farms to help potential limited-resource members overcome income barriers. Those strategies include acceptance of government food assistance, payment plans, working shares, subsidized low-income shares, low-cost shares, transportation assistance, bartering, outreach efforts, and connections to emergency food assistance.
Colonization of human lung grafts in SCID‐hu mice by human colon carcinoma cells

Human colon carcinoma cell lines were examined in a colonization assay using SCID‐hu mice engrafted with human fetal lung (HFL) tissues. Cell lines SW620 and COLO 320DM, derived from metastatic tumors, colonized HFL grafts after i.v. injection into SCID‐hu mice. Cell lines SW480 and T34 initiated from primary colon tumors were unable to colonize HFL grafts. The ability to colonize HFL grafts but not mouse lungs of SCID‐hu‐L mice correctly reflects the clinical origin of these human colon carcinoma cell lines. Expression of a number of cell adhesion molecules was examined on SW480, SW620 and in vivo selected highly aggressive variants of SW620. NCAM and integrin α3 expressed on the surface of SW480 cells were lost from metastatic cells, while carbohydrate ligands sialyl Lewis x and a, previously shown to be upregulated in metastatic colorectal tumors, were expressed at higher levels on colonizing cells. Unlike SW480, SW620 and its in vivo selected variants expressed RNA for calcium binding protein calbindin‐D28K, a neuroendocrine marker. Acquisition of neuroendocrine features might be of potential importance in the development of the metastatic phenotype. © 1996 Wiley‐Liss, Inc.
Regulation of Closterovirus Gene Expression Examined by Insertion of a Self-Processing Reporter and by Northern Hybridization

ABSTRACT A reporter open reading frame (ORF) coding for a fusion of bacterial β-glucuronidase (GUS) with a proteinase domain (Pro) derived from tobacco etch potyvirus was utilized for tagging individual genes of beet yellows closterovirus (BYV). Insertion of this reporter ORF between the first and second codons of the BYV ORFs encoding the HSP70 homolog (HSP70h), a major capsid protein (CP), and a 20-kDa protein (p20) resulted in the expression of the processed GUS-Pro reporter from corresponding subgenomic RNAs. The high sensitivity of GUS assays permitted temporal analysis of reporter accumulation, revealing early expression from the HSP70h promoter, followed by the CP promoter and later the p20 promoter. The kinetics of transcription of the remaining BYV genes encoding a 64-kDa protein (p64), a minor capsid protein (CPm), and a 21-kDa protein (p21) were examined via Northern blot analysis. Taken together, the data indicated that the temporal regulation of BYV gene expression includes early (HSP70h, CPm, CP, and p21 promoters) and late (p64 and p20 promoters) phases. It was also demonstrated that the deletion of six viral genes that are nonessential for RNA amplification resulted in a dramatic increase in the level of transcription from one of the two remaining subgenomic promoters. Comparison with other positive-strand RNA viruses producing multiple subgenomic RNAs showed the uniqueness of the pattern of closterovirus transcriptional regulation.
Apparent audit failures and value relevance of earnings and book value

Purpose - The purpose of this paper is to examine the value relevance of accounting information in cases of apparent audit failures. Design/methodology/approach - The authors adopt the bootstrapping technique and compare the value relevance of key accounting information across samples of firms experiencing apparent audit failures with matched non-audit failure firms. Findings - Accounting information is found to be less value relevant for firms experiencing apparent audit failures, regardless of auditor reputation. Research limitations/implications - This study has limitations due to the Originality/value - The paper gives support to the assertion that the market appears to rely less on accounting numbers when audit failures occur, even though formal allegations of audit failure may not appear until years after their occurrence. In addition to contributing to value-relevance research by providing empirical evidence for the market phenomenon around the time of material misstatements, the paper demonstrates an innovative application of bootstrapping to test for differences in
Internal finance and capital accumulation in a dynamic general equilibrium model with credit constraints

This paper uses a dynamic general equilibrium setup with overlapping generations to provide a better understanding of the causes and consequences of credit constraints resulting from asymmetric information and moral hazard. These constraints imply that the entrepreneur’s access to credit is limited by the amount of internal funds available. In a general equilibrium setup, internal funds and the interest rate are endogenous. It is shown that credit constraints have large effects either by redistributing wealth or by changing the equilibrium capital stock, or both. Insofar as the interest rate elasticity of savings is close to zero, the effects on income distribution are likely to be much more important than the effects on output and investment. Even though Pareto improving policies do exist, they seem extremely difficult to implement in practice. Even in our simple setup with no borrower heterogeneity, simple transfers from unconstrained households to finance-constrained entrepreneurs may well fail to lead to Pareto superior outcomes and to eliminate the inefficiencies generated by capital market imperfections, even though they would have a positive impact on aggregate investment and output.
A methodology using subjective and objective measures to compare plaque inhibition by toothpastes.

OBJECTIVES Plaque scoring usually employs subjective indices. The aim was to compare plaque inhibition of three toothpastes using two objective and one subjective measures of plaque. MATERIAL AND METHODS Formulations were: (1) an experimental anti-plaque paste (test); (2) an experimental paste (minus active or negative control); and (3) a proprietary anti-plaque toothpaste product (positive control). The study was a blind, randomised crossover design using a 4-day, no tooth brushing, plaque regrowth model and involving 22 healthy subjects. After baseline plaque removal, subjects rinsed twice a day with slurries of the allocated paste. On day 5, plaque was scored by index, wet weight and optical density of extracted disclosing solution from the plaque (stain intensity). RESULTS All data showed the same pattern. There were highly significant subject and treatment effects but not period effects. The positive control was highly significantly more effective in plaque control than the test and minus active experimental formulations, which in turn were not significantly different from each other. There were strong and significant correlations between pairs of scoring methods particularly wet weight and stain intensity. CONCLUSION The use of objective methods of plaque alongside conventional subjective indices provided convincing evidence for increased discriminatory power in a study comparing plaque inhibition by toothpastes.
The Learning Organization as Facilitator of Complex NPD Projects

With rapid technological and market changes, new product development (NPD) complexity is a significant issue that organizations continually face in their development projects. The inability to recognize and/or manage complexity can cause the best-intentioned projects to fail. By creating a learning organization attuned to complexity and its management, however, companies are more likely to have the knowledge and skills essential to respond competently to the complexity frequently encountered in NPD projects. In this paper, we first define complexity in NPD and then examine organizational learning as it can assist in dealing with development complexity. Next, we report findings from an exploratory research study on organizational learning and its relationship to product development complexity. The study is based on 32 field interviews with NPD participants regarding their learning experiences in dealing with complexity; the transfer of project learning to other projects; and the factors that minimize/block the transfer of learning among projects. Based on our research, we advance several suggestions for implementing a learning organization designed specifically to capitalize on the experiences of development firms' efforts in dealing with complexity and its consequences.
HPV awareness, knowledge and attitudes among older African-American women.

OBJECTIVE To assess correlates of human papillomavirus (HPV) awareness, knowledge, and attitudes among older, church-going African-American women. METHODS Participants (N = 759), aged 40-80, answered survey questions about HPV awareness, knowledge, and attitudes toward vaccination of adolescent daughters. Associations between participant characteristics and HPV items were assessed using chi-square tests and logistic regression analyses. RESULTS Younger age, higher education, a family history of cancer, and less spirituality were each associated with HPV awareness individually, and when considered jointly in a single model (p values <.038). Higher education was related to HPV knowledge (p = .006). CONCLUSIONS African-American women of older age, less education, no family history of cancer, and/or higher spirituality might benefit from targeted church-based HPV educational campaigns.
REFLECTIONS ON WOMEN'S EMPOWERMENT THROUGH LOCAL REPRESENTATION IN SOUTH KOREA

Abstract After the introduction of local autonomy, Korean feminists advocated women9s participation in local politics based on life politics and spillover effect. While life politics relies on unverified gender differences, spillover effect is invalid due to the centralized political system. Therefore, local strategy needs to be supplemented with a national strategy.