Miracle-dz/UniFAR-FTUs huggingface dataset:
Tourists and souvenirs: changes through time, space and meaning

This study focusses on souvenirs and their meanings. It employs both quantitative and qualitative methods to investigate time-dependent changes in tourists' attitudes toward souvenirs and the process through which objects become souvenirs. The research indicates that the passage of time and gaining tourist experience does affect the meanings of tourists' souvenirs. The changes in the meanings given to souvenirs affected their location in the tourists' homes. The most common change was the diminished significance of souvenirs among most of the participants. The research also establishes the importance of the post-journey assignation of meaning to objects as part of the process by which everyday objects are transformed into meaningful bearers of memories. This study stresses the need to redefine the concept of ‘souvenir’ in order to accommodate a broader definition. The term should include any object that reminds us of the journey, even if it was not acquired during the journey itself and was not intended to serve as a souvenir. Expanding the term ‘souvenir’, will require a new classification of souvenirs, thereby changing people's perception of them.
REGULARITY OF APOLLONIAN GASKETS

Apollonian gaskets are formed by repeatedly filling the gaps between three mutually tangent circles with further tangent circles. In this paper we give explicit formulas for the the limiting pair correlation and the limiting nearest neighbor spacing of centers of circles from a fixed Apollonian gasket. These are corollaries of the convergence of moments that we prove. The input from ergodic theory is an extension of Mohammadi-Oh’s Theorem on the equidisribution of expanding horospheres in infinite volume hyperbolic spaces.
[TIVA-TCI (Total IntraVenous Anesthesia-Target Controlled Infusion) versus isoflurane anesthesia for laparoscopic cholecystectomy. Postoperative nausea and vomiting, and patient satisfaction].

UNLABELLED Numerous studies have shown that TIVA is followed by a significant reduction in the incidence of PONV in day-case surgery, including laparoscopic cholecystectomy, where the incidence of PONV can reach 70% according to some studies. TCI is the TIVA technique that maintain a constant plasma concentration due to pharmacokynetic models incorporated in TCI device that inject the anesthetic agent. Besides implementing TIVA-TCI in clinical practice in Romania, our study was designed to evaluate the impact of TIVA-TCI on postoperative outcome and our patient satisfaction after laparoscopic cholecystectomy. PATIENTS AND METHODS After informed consent, 70 patients ASAI/II undergoing laparoscopic cholecystectomy were randomized in 2 equal study groups: group 1 (n = 35) included patients with TIVA-TCI with propofol (Cpi = 4 microg/ml) and remifentanil, and group 2 (n = 35) were patients undergoing Isoflurane anesthesia. In both groups propofol was administered during induction and remifentanil followed the same protocol: 0.5 microg/kg/min in the first minute during induction, followed by 0.25 microg/kg/min. This infusion was modified by 0.05 microg/kg/min steps according to analgesic needs. PONV (evaluated as both incidence and number of episodes), severity of pain and patient satisfaction score IOWA were compared between study groups. RESULTS Both the incidence of PONV (p = 0.03) and the number of episodes/24 h/patients (p = 0.01) were significantly lower in TIVA-TCI group, while there was no significant difference in opioid requirements in study groups (p = 0.21). Patients IOWA satisfaction score at 24 hours postoperatively was significantly higher in TIVA-TCI groups (p = 0.0001). CONCLUSIONS Compared with Isoflurane, TIVA-TCI was followed by significantly lower incidence of PONV and significantly greater patients satisfaction.
A longitudinal evaluation of adolescent depression and adult obesity.

BACKGROUND Prior studies have had conflicting results regarding the relationship between adolescent depression and adult obesity. OBJECTIVE To test the hypothesis that depression in adolescence would increase the risk for obesity in early adulthood. METHODS We used data from a longitudinal study of a birth cohort of children born between April 1, 1972, and March 31, 1973, in Dunedin, New Zealand (N = 1037). These data included regular diagnostic mental health interviews and height/weight measurements throughout childhood and adolescence. We performed logistic regression analyses to assess the relationship between major depression in early or late adolescence and the risk for obesity at 26 years of age. RESULTS Major depression occurred in 7% of the cohort during early adolescence (11, 13, and 15 years of age) and 27% during late adolescence (18 and 21 years of age). At 26 years of age, 12% of study members were obese. After adjusting for each individual's baseline body mass index (calculated as the weight in kilograms divided by the square of height in meters), depressed late adolescent girls were at a greater than 2-fold increased risk for obesity in adulthood compared with their nondepressed female peers (relative risk, 2.32; 95% confidence interval, 1.29-3.83). A dose-response relationship between the number of episodes of depression during adolescence and risk for adult obesity was also observed in female subjects. The association was not observed for late adolescent boys or for early adolescent boys or girls. CONCLUSIONS Depression in late adolescence is associated with later obesity, but only among girls. Future studies should address reasons for these age and sex differences and the potential for intervention to reduce the risk for adult obesity in depressed older adolescent girls.
Hypoxia-Induced Activation of N-methyl-D-aspartate Receptors Causes Retinal Ganglion Cell Death in the Neonatal Retina

Abstract It is well established that hypoxia causes excess accumulation of glutamate in developing neural tissues. This study aimed to elucidate the mechanism by which glutamate can cause retinal ganglion cell (RGC) death through the N-methyl-D-aspartate (NMDA) receptors (NR) in the developing retina. One-day-old Wistar rats were exposed to hypoxia for 2 hours and then killed at different time points. Normal age-matched rats were used as controls. NR1, NR2A-D, and NR3A messenger RNA and protein expression showed significant increases over control values, notably at early time points (3 hours to 7 days) after the hypoxic exposure, and immunoexpression of NR1, NR2A-D and NR3A on retinal ganglion cells (RGCs) was enhanced in hypoxic rats and this was confirmed in cultured hypoxic RGCs. Ca2+ influx in cultured RGCs was increased after hypoxic exposure, and the intracellular Ca2+ concentration was suppressed by MK-801. Mitochondrial permeability transition pore opening, mitochondrial/cytosolic cytochrome c, and cytosolic caspase-3 expression levels were significantly increased in the hypoxic RGCs. These increases were reversed by MK-801, suggesting that the NMDA receptor subunits in theretina respond rapidly to the hypoxia-induced glutamate overload that leads to the cascade of events that result in RGC death.
Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue.

AIMS In excitable cells, KIR2.x ion-channel-carried inward rectifier current (IK₁) is thought to set the negative and stable resting membrane potential, and contributes to action potential repolarization. Loss- or gain-of-function mutations correlate with cardiac arrhythmias and pathological remodelling affects normal KIR2.x protein levels. No specific IK1 inhibitor is currently available for in vivo use, which severely hampers studies on the precise role of IK1 in normal cardiac physiology and pathophysiology. The diamine antiprotozoal drug pentamidine (P) acutely inhibits IK₁ by plugging the cytoplasmic pore region of the channel. We aim to develop more efficient and specific IK₁ inhibitors based on the P structure. METHODS AND RESULTS We analysed seven pentamidine analogues (PA-1 to PA-7) for IK₁ blocking potency at 200 nM using inside-out patches from KIR2.1 expressing HEK-293 cells. PA-6 showed the highest potency and was tested further. PA-6 blocked KIR2.x currents of human and mouse with low IC₅₀ values (12-15 nM). Modelling indicated that PA-6 had less electrostatic but more lipophilic interactions with the cytoplasmic channel pore than P, resulting in a higher channel affinity for PA-6 (ΔG -44.1 kJ/Mol) than for P (ΔG -31.7 kJ/Mol). The involvement of acidic amino acid residues E224 and E299 in drug-channel interaction was confirmed experimentally. PA-6 did not affect INav1.5, ICa-L, IKv4.3, IKv11.1, and IKv7.1/minK currents at 200 nM. PA-6 inhibited the inward (50 nM 40%; 100 nM 59%; 200 nM 77%) and outward (50 nM 40%; 100 nM 76%; 200 nM 100%) components of IK₁ in isolated canine adult-ventricular cardiomyocytes (CMs). PA-6 prolonged action potential duration of CMs by 8 (n = 9), 26 (n = 5), and 34% (n = 11) at 50, 100, and 200 nM, respectively. Unlike P, PA-6 had no effect on KIR2.1 channel expression at concentrations from 0.1 to 3 μM. However, PA-6 at 10 μM increased KIR2.1 expression levels. Also, PA-6 did not affect the maturation of hERG, except when applied at 10 μM. CONCLUSION PA-6 has higher efficiency and specificity to KIR2.x-mediated current than P, lengthens action potential duration, and does not affect channel trafficking at concentrations relevant for complete IK₁ block.
Convergent Network Approximation for the Continuous Euclidean Length Constrained Minimum Cost Path Problem

In many path-planning situations we would like to find a path of constrained Euclidean length in $\mathbb{R}^2$ that minimizes a line integral. We call this the Continuous Length-Constrained Minimum Cost Path Problem (C-LCMCPP). Generally, this will be a nonconvex optimization problem, for which continuous approaches ensure only locally optimal solutions. However, network discretizations yield weight constrained network shortest path problems (WCSPPs), which can in practice be solved to global optimality, even for large networks; we can readily find a globally optimal solution to an approximation of the C-LCMCPP. Solutions to these WCSPPs yield feasible solutions and hence upper bounds. We show how networks can be constructed, and a WCSPP in these networks formulated, so that the solutions provide lower bounds on the global optimum of the continuous problem. We give a general convergence scheme for our network discretizations and use it to prove that both the upper and lower bounds so generated converge to the global optimum of the C-LCMCPP, as the network discretization is refined. Our approach provides a computable lower bound formula (of course, the upper bounds are readily computable). We give computational results showing the lower bound formula in practice, and compare the effectiveness of our network construction technique with that of standard grid-based approaches in generating good quality solutions. We find that for the same computational effort, we are able to find better quality solutions, particularly when the length constraint is tighter.
Comparison of Milk Fat Globule Membrane (MFGM) Proteins of Chianina and Holstein Cattle Breed Milk Samples Through Proteomics Methods

Identification of proteins involved in milk production is important to understand the biology of lactation. Many studies have advanced the understanding of mammary function and milk secretion, but the critical molecular mechanisms implicated in milk fat secretion is still incomplete. Milk Fat Globules are secreted from the apical surface of the mammary cells, surrounded by a thin membrane bilayer, the Milk Fat Globule Membrane (MFGM), formed by proteins which have been suggested to be cholesterolemia-lowering factors, inhibitors of cancer cell growth, vitamin binders, bactericidal, suppressors of multiple sclerosis. Using a proteomic approach, we compared MFGM from milk samples of individuals belonging to two different cattle breeds, Chianina and Holstein, representative of selection for milk and meat traits, respectively. We were able to isolate some of the major MFGM proteins in the examined samples and to identify differences between the protein fractions of the two breeds. We detected differences in the amount of proteins linked to mammary gland development and lipid droplets formation, as well as host defence mechanisms. We have shown that proteomics is a suitable, unbiased method for the study of milk fractions proteins and a powerful tool in nutritional genomics.
US Immigrants’ Patterns of Acculturation are Sensitive to Their Age, Language, and Cultural Contact but Show No Evidence of a Sensitive Window for Acculturation

Recent research observed a sensitive window, at about 14 years of age, in the acculturation rates of Chinese immigrants to Canada. Tapping an online sample of us immigrants (n=569), we tested these relationships in a broader population and explored connections with new potentially causally related variables: formal education, language ability and contact with heritage-culture and mainstream United States individuals, both now and at immigration. While we found that acculturation decreased with age at immigration and increased with years in the us, we did not observe a similar sensitive window (i.e., change in rate with age). We also present an exploratory path analysis, exposing the relationships in our sample between acculturation and the variables above. The novel relationships documented here can improve theorising about this rich and complex empirical phenomenon.
Fabricate 2 . 5 D Shadow Art Sculpture

Shadow art is a practice of arranging objects in space to produce surprising shadow. Creating such an art piece has always been labor intensive and time consuming, through trial-and-error methods. Indeed, the time complexity of solving the shadows art problem is inevitably NP hard. In this work, we present a computational method that determines a 2D arrangement of 3D objects to produce a desired shadow image. We demonstrate that the proposed tool successfully reproduce the desired shadow through both simulation and physical fabrication.
Non‐invasive ventilation during arm exercise and ground walking in patients with chronic hypercapnic respiratory failure

Background and objective: People with chronic hypercapnic respiratory failure (HRF) often have a ventilatory limitation to exercise with difficulty performing activities of daily living. Although non‐invasive ventilation (NIV) appears to reduce the ventilatory limitation and improve exercise performance in people with severe COPD, the effect of NIV during functional activities such as unsupported arm exercise (UAE) and ground walking in people with chronic HRF is unclear.
A pair of receptor-like kinases is responsible for natural variation in shoot growth response to mannitol treatment in Arabidopsis thaliana.

Growth is a complex trait that adapts to the prevailing conditions by integrating many internal and external signals. Understanding the molecular origin of this variation remains a challenging issue. In this study, natural variation of shoot growth under mannitol-induced stress was analyzed by standard quantitative trait locus mapping methods in a recombinant inbred line population derived from a cross between the Col-0 and Cvi-0 Arabidopsis thaliana accessions. Cloning of a major QTL specific to mannitol-induced stress condition led to identification of EGM1 and EGM2, a pair of tandem-duplicated genes encoding receptor-like kinases that are potentially involved in signaling of mannitol-associated stress responses. Using various genetic approaches, we identified two non-synonymous mutations in the EGM2[Cvi] allele that are shared by at least ten accessions from various origins and are probably responsible for a specific tolerance to mannitol. We have shown that the enhanced shoot growth phenotype contributed by the Cvi allele is not linked to generic osmotic properties but instead to a specific chemical property of mannitol itself. This result raises the question of the function of such a gene in A. thaliana, a species that does not synthesize mannitol. Our findings suggest that the receptor-like kinases encoded by EGM genes may be activated by mannitol produced by pathogens such as fungi, and may contribute to plant defense responses whenever mannitol is present.
Design for individuals, design for groups: tradeoffs between power and workspace awareness

Users of synchronous groupware systems act both as individuals and as members of a group, and designers must try to support both roles. However, the requirements of individuals and groups often conflict, forcing designers to support one at the expense of the other. The tradeoff is particularly evident in the design of interaction techniques for shared workspaces. Individuals demand powerful and flexible means for interacting with the workspace and its artifacts, while groups require information about each other to maintain awareness. Although these conflicting requirements present real problems to designers, the tension can be reduced in some cases. We consider the tradeoff in three areas of groupware design: workspace navigation, artifact manipulation, and view representation. We show techniques such as multiple viewports, process feedthrough, action indicators, and view translations that support the needs of both individuals and groups.
Work-to-family conflict and its relationship with satisfaction and well-being: a one-year longitudinal study on gender differences

The present study produced new knowledge about gender differences with respect to work-to-family conflict and its longitudinal relations with indicators of satisfaction and well-being. The study examined the longitudinal relations between work-to-family conflict and self-reported satisfaction and well-being in the domains of work (job satisfaction), family (marital satisfaction, parental distress) as well as overall (psychological and physical) symptoms. Data were obtained from a random sample of Finnish men (n=208) and women (n=218) who were employed and had either a partner or/and children. A survey was conducted at two points in time, in 1999 (Time 1), and one year later, in 2000 (Time 2). The results revealed that, among women, work-to-family conflict perceived at Time 1 significantly predicted job dissatisfaction, parental distress as well as psychological symptoms at Time 2. However, among men, a low level of satisfaction or well-being at Time 1 (marital dissatisfaction, parental distress, psychological and physical symptoms) functioned as a precursor of work-to-family conflict perceived at Time 2. In addition, the experience of work-to-family conflict turned out to be relatively stable for both genders over the time period of one year. It is likely that work-to-family conflict will continue to affect employees, and should be a central focus for organizations.
The Influence of Sesame Street and Mister Rogers' Neighborhood on Children's Social Behavior in the Preschool

COATES, BRIAN; PUSSER, H. ELLISON; and GOODMAN, IRENE. The Influence of "Sesame Street" and "Mister Rogers' Neighborhood" on Children's Social Behavior in the Preschool. CHILD DEVELOPMENT, 1976, 47, 138-144. This study was designed to assess the influence of "Sesame Street" and "Mister Rogers' Neighborhood," 2 popular children's television programs, on children's social behavior in the preschool. Observations of the children's behavior were conducted before (baseline), during (treatment), and after (posttest) 1 week of exposure to each of the programs. These observations consisted of the frequency of the children's giving of positive reinforcement and punishment to other children and to adults in the preschool. The children's social contacts with other children and with adults were also measured. For children whose baseline scores were low for an observational category, "Sesame Street" significantly increased the giving of positive reinforcement and punishment to, and social contacts with, other children and with adults in the preschool. For children whose baseline scores were high, "Sesame Street" had no sigpificant effect on behavior. For all children (high and low in baseline scores), "Mister Rogers Neighborhood" significantly increased the giving of positive reinforcement to, and social contacts with, other children and with adults in the preschool. These results are generally consistent with expectations based on a content analysis of the 2 programs (Coates & Pusser 1975).
Early depth assessment of local burns by dermoscopy: a new frontier of dermoscopic evaluation.

UNLABELLED This article has been retracted. See Notice of Retraction. OBJECTIVE To investigate the effectiveness of early depth assessment of local burns, the depth of which is difficult to assess with the naked eye, by dermoscopy. DESIGN The morphological findings of burn wounds were prospectively evaluated by dermoscopy and videomicroscopy. Prior to dermoscopic and videomicroscopic measurement, clinical assessment was performed. All patients received conservative treatment for 21 days after injury. SETTING A burns unit at a primary care hospital. PARTICIPANTS Thirty-two patients with 41 intermediate-depth local burn wounds were included. Inclusion criteria were time to presentation greater than 24 hours after injury and total burn size greater than 1% and less than 10% of the total body surface area. MAIN OUTCOME MEASURES Primary healing within 21 days (superficial partial thickness) and failure of primary healing within 21 days (deep partial thickness). The accuracy, sensitivity, and specificity of the assessment according to the algorithm proposed in this study were evaluated by dermoscopy, and the accuracy of the dermoscopic measurements was compared with videomicroscopic measurements and clinical assessments. RESULTS The results of dermoscopic measurements according to the proposed algorithm showed an accuracy of 93%, sensitivity of 86%, and specificity of 100%. The dermoscopic measurements were significantly more accurate compared with clinical assessment (P = .01). CONCLUSIONS Dermoscopy is a noninvasive, portable, relatively inexpensive, and effective approach for assessment of the burn wound healing potential. It is more accurate if compared with clinical observation in burn depth assessment. It has a broader utility and is equally or more accurate compared with the more expensive videomicroscopy.
lolal Is an Evolutionarily New Epigenetic Regulator of dpp Transcription during Dorsal–Ventral Axis Formation

Secreted ligands in the Dpp/BMP family drive dorsal–ventral (D/V) axis formation in all Bilaterian species. However, maternal factors regulating Dpp/BMP transcription in this process are largely unknown. We identified the BTB domain protein longitudinals lacking-like (lolal) as a modifier of decapentaplegic (dpp) mutations. We show that Lolal is evolutionarily related to the Trithorax group of chromatin regulators and that lolal interacts genetically with the epigenetic factor Trithorax-like during Dpp D/V signaling. Maternally driven LolalHA is found in oocytes and translocates to zygotic nuclei prior to the point at which dpp transcription begins. lolal maternal and zygotic mutant embryos display significant reductions in dpp, pMad, and zerknullt expression, but they are never absent. The data suggest that lolal is required to maintain dpp transcription during D/V patterning. Phylogenetic data revealed that lolal is an evolutionarily new gene present only in insects and crustaceans. We conclude that Lolal is the first maternal protein identified with a role in dpp D/V transcriptional maintenance, that Lolal and the epigenetic protein Trithorax-like are essential for Dpp D/V signaling and that the architecture of the Dpp D/V pathway evolved in the arthropod lineage after the separation from vertebrates via the incorporation of new genes such as lolal.