Miracle-dz/UniFAR-FTUs huggingface dataset:
Negative correlation between X-linked inhibitors of apoptosis and second mitochondria-derived activator of caspase expression levels in cervical carcinoma and cervical intraepithelial neoplasia

X-linked inhibitors of apoptosis (XIAP) and second mitochondria-derived activator of caspase (Smac) have been widely reported to serve roles in the development of cervical carcinoma. The present study analyzed the associations between the expression levels of XIAP and Smac in normal cervical epithelium, cervical intraepithelial neoplasia (CIN) and cervical carcinoma. Immunohistochemistry staining of formalin-fixed, paraffin-embedded tissue sections was performed in order to analyze the expression levels of XIAP and Smac in 15 cases of normal cervical tissues, 69 cases of CIN and 76 cases of cervical carcinoma. All the tissue samples were confirmed by pathological diagnosis. The association of XIAP and Smac expression levels was analyzed using one-way analysis of variance, χ2 tests and Spearman's ρ for the nonparametric bi-variant correlation analysis. Overall survival was determined using the log-rank test and Kaplan-Meier survival curves. The expression level of XIAP was increased in CIN and cervical carcinoma tissues compared with normal cervical tissues, whereas Smac demonstrated a converse expression pattern to XIAP in these tissues. The positive staining level of XIAP protein was increased in grade 3 CIN compared with that in grade 1–2 CIN, and was significantly higher in the less-differentiated tissue of cervical carcinoma compared with the well- or medium-differentiated tissues (P<0.05). The staining level was also significantly increased in cervical carcinoma with stage 2b-3 compared with tissues from stage 1–2a carcinoma (P<0.05). The expression levels of Smac were in opposition to these results. XIAP was associated with pelvic lymph node metastasis, whereas no association was identified with Smac expression. The expression level of XIAP was significantly and negatively associated with cell survival time in cervical carcinoma, whereas the expression level of Smac was significantly and positively associated with cell survival time in cervical carcinoma. Therefore, XIAP and Smac may participate in the development of cervical cancer. The expression levels of XIAP and Smac were significantly and inversely associated. This may be useful in early diagnosis, evaluation of surgery and chemotherapy and the prognosis of cervical carcinoma.
On the Impossibility of Efficiency in Production

In this paper we consider the possibility that a firm may use costly resources to improve its technical efficiency. Results from static analyses imply that technical efficiency is determined by the configuration of factor prices. A dynamic model of the firm is developed under the assumption that managerial skill contributes to technical efficiency. Dynamic analysis shows that the firm can never be technically efficient if it maximizes profits, the steady state is always inefficient, and it is locally stable.
Tissue stretch decreases soluble TGF‐β1 and type‐1 procollagen in mouse subcutaneous connective tissue: Evidence from ex vivo and in vivo models

Transforming growth factor beta 1 (TGF‐β1) plays a key role in connective tissue remodeling, scarring, and fibrosis. The effects of mechanical forces on TGF‐β1 and collagen deposition are not well understood. We tested the hypothesis that brief (10 min) static tissue stretch attenuates TGF‐β1‐mediated new collagen deposition in response to injury. We used two different models: (1) an ex vivo model in which excised mouse subcutaneous tissue (N = 44 animals) was kept in organ culture for 4 days and either stretched (20% strain for 10 min 1 day after excision) or not stretched; culture media was assayed by ELISA for TGF‐β1; (2) an in vivo model in which mice (N = 22 animals) underwent unilateral subcutaneous microsurgical injury on the back, then were randomized to stretch (20–30% strain for 10 min twice a day for 7 days) or no stretch; subcutaneous tissues of the back were immunohistochemically stained for Type‐1 procollagen. In the ex vivo model, TGF‐β1 protein was lower in stretched versus non‐stretched tissue (repeated measures ANOVA, P < 0.01). In the in vivo model, microinjury resulted in a significant increase in Type‐1 procollagen in the absence of stretch (P < 0.001), but not in the presence of stretch (P = 0.21). Thus, brief tissue stretch attenuated the increase in both soluble TGF‐β1 (ex vivo) and Type‐1 procollagen (in vivo) following tissue injury. These results have potential relevance to the mechanisms of treatments applying brief mechanical stretch to tissues (e.g., physical therapy, respiratory therapy, mechanical ventilation, massage, yoga, acupuncture). J. Cell. Physiol. 214: 389–395, 2008. © 2007 Wiley‐Liss, Inc.
R&D Spending, Knowledge Capital, and Agricultural Productivity Growth: A Bayesian Approach

Abstract In this article, we employ Bayesian hierarchical modeling to better capture and communicate the uncertainties surrounding the transformation of U.S. public agricultural research and development (R&D) expenditures to knowledge capital stocks as well as its contribution to the historic growth of U.S. agricultural total factor productivity. Compared to studies based on classical statistics, analytical methods grounded in Bayesian inference explicitly incorporate existing information and permit revision of our knowledge regarding the distribution of the unknown model parameters as additional information becomes available. Bayesian hierarchical modeling is particularly useful in statistically estimating the underlying parameters of the R&D lag weight structure, as well as the R&D knowledge stocks given observed data on agricultural productivity and R&D expenditures. Our results show a significant level of uncertainty on the R&D lag weight structure, indicating that published assumptions about the R&D lag structure can now be tested and validated against available data. Estimating the R&D lag weights and knowledge stocks also make a large difference in the uncertainties surrounding economic returns from R&D investments. Indeed, our results show that the best‐fit linear model yields slightly higher mean returns to R&D spending relative to the log model results and have significantly less uncertainty. This suggests that marginal returns to U.S. public agricultural research spending might have remained relatively constant despite a century of growth in expenditure. Furthermore, we find that such investments could take a longer time to bear fruit than previously realized.
Academic career making and the double-edged role of academic housework

ABSTRACT Internationalisation, competition and performance orientation are nowadays essential in the managing and financing of universities. This pattern has intensified with the austerity measures and fiscal consolidation that followed the financial crisis in 2008. This article examines the academic labour process and career making of academics from a gender perspective. Based on findings deriving from an Icelandic University, we argue that the austerity measures and increased focus on becoming one of the top universities in the world has changed the official responsibilities of academics. We show how ‘academic housework’ affects academic capital and how the amount of academic housework is unequally distributed between senior academics and newcomers. While the majority of academics conform to this contemporary academic system, marginalised groups put up some resistance but with limited success.
Learning to Match

Outsourcing tasks to previously unknown parties is becoming more common. One specific such problem involves matching a set of workers to a set of tasks. Even if the latter have precise requirements, the quality of individual workers is usually unknown. The problem is thus a version of matching under uncertainty. We believe that this type of problem is going to be increasingly important. When the problem involves only a single skill or type of job, it is essentially a type of bandit problem, and can be solved with standard algorithms. However, we develop an algorithm that can perform matching for workers with multiple skills hired for multiple jobs with multiple requirements. We perform an experimental evaluation in both single-task and multi-task problems, comparing with the bounded $\epsilon$-first algorithm, as well as an oracle that knows the true skills of workers. One of the algorithms we developed gives results approaching 85\% of oracle's performance. We invite the community to take a closer look at this problem and develop real-world benchmarks.
Defective Interleukin-10 Synthesis by Peripheral Blood Mononuclear Cells among Hemodialysis Patients

Background: Interleukin-10 (IL-10), a potent regulatory monokine produced by activated mononuclear cells, provides an efficient autocrine mechanism for controlling proinflammatory cytokine synthesis. We hypothesized that defective synthesis of IL-10 could contribute to the inflammatory state in hemodialysis (HD) patients due to impaired feedback inhibition of proinflammatory cytokine production. Methods: We compared peripheral blood mononuclear cell (PBMC) synthesis and transcription of IL-10 and TNF-α in 12 patients with end-stage renal disease on long-term maintenance HD and a control group of 10 healthy subjects. Results: The synthesis of IL-10 by unstimulated PBMC was detectable in 5 of 12 (42%) HD patients as compared to 7 of 10 (70%) controls (p = 0.02). IL-10 synthesis in response to endotoxin (ET) by PBMC from HD patients was significantly lower when compared to the robust response in the control group (p = 0.008). Among the HD patients, there was a positive correlation between ET-stimulated IL-10 synthesis and the duration of time on dialysis. Unstimulated and ET-stimulated synthesis of TNF-α by PBMC did not differ between the 2 groups. In the HD patients, there was an inverse correlation between TNF-α and IL-10 synthesis by ET-stimulated PBMC, suggesting a regulatory effect of IL-10 on PBMC TNF-α synthesis. There was also an inverse correlation between plasma albumin and ET-stimulated TNF-α synthesis by PBMC among HD patients. TNF-α mRNA expression did not differ in HD patients relative to healthy controls. In contrast, when IL-10 mRNA from ET-stimulated PBMC was quantified, there was marked difference between the 2 groups indicating a transcriptional defect in IL-10 synthesis in PBMC from HD patients. Conclusion: Our observations indicate a marked abnormality in IL-10 synthesis by PBMC from HD patients probably related to a transcriptional defect. Low PBMC IL-10 synthesis may contribute to a chronic inflammatory state in these patients by defective feedback inhibition of proinflammatory cytokine production.
Digital Device Error Rate Trends in Advanced CMOS Technologies

In this paper, data are presented from test chips in four technology nodes. With this data, the trends in single event effects as feature sizes shrink are studied. Some of the trends discussed include upset thresholds, shrinking cross sections, multiple bit upsets, and per bit error rate trends. Also included in this paper is some of the first ever heavy ion data from a 65 nm CMOS technology. With data from the 250 nm, 180 nm, 90 nm, and 65 nm technology nodes, the past, present, and future of what the radiation effects community has dealt with and will be dealing with when it comes to single event effects is presented
Generation of sub wavelength super-long dark channel using high NA lens axicon.

We investigate the focusing properties of a double-ring-shaped azimuthally polarized beam by a high numerical aperture (NA) lens axicon based on vector diffraction theory. We observe that our proposed system generates a sub wavelength focal hole of 0. 5λ having large uniform focal depth of 48λ without any annular aperture. We also observed that the distribution of the total intensity near the focus has little variation with the degree of truncation β of the incident beam by the pupil. The authors expect such a super-long dark channel may find applications in optical, biological, and atmospheric sciences.
Adverse Drug Reaction Identification and Extraction in Social Media: A Scoping Review

Background The underreporting of adverse drug reactions (ADRs) through traditional reporting channels is a limitation in the efficiency of the current pharmacovigilance system. Patients’ experiences with drugs that they report on social media represent a new source of data that may have some value in postmarketing safety surveillance. Objective A scoping review was undertaken to explore the breadth of evidence about the use of social media as a new source of knowledge for pharmacovigilance. Methods Daubt et al’s recommendations for scoping reviews were followed. The research questions were as follows: How can social media be used as a data source for postmarketing drug surveillance? What are the available methods for extracting data? What are the different ways to use these data? We queried PubMed, Embase, and Google Scholar to extract relevant articles that were published before June 2014 and with no lower date limit. Two pairs of reviewers independently screened the selected studies and proposed two themes of review: manual ADR identification (theme 1) and automated ADR extraction from social media (theme 2). Descriptive characteristics were collected from the publications to create a database for themes 1 and 2. Results Of the 1032 citations from PubMed and Embase, 11 were relevant to the research question. An additional 13 citations were added after further research on the Internet and in reference lists. Themes 1 and 2 explored 11 and 13 articles, respectively. Ways of approaching the use of social media as a pharmacovigilance data source were identified. Conclusions This scoping review noted multiple methods for identifying target data, extracting them, and evaluating the quality of medical information from social media. It also showed some remaining gaps in the field. Studies related to the identification theme usually failed to accurately assess the completeness, quality, and reliability of the data that were analyzed from social media. Regarding extraction, no study proposed a generic approach to easily adding a new site or data source. Additional studies are required to precisely determine the role of social media in the pharmacovigilance system.
A Systematic Review of the Experiences of Siblings of Children With Cancer

Background: When there is a child with cancer in the family, the entire family is affected. Childhood cancer is a highly stressful experience that affects the adaptation of family member to psychosocial tasks. Many of the family stresses and changes that accompany childhood cancer have a severe impact on siblings. An understanding of the experiences and needs of such siblings is vital. Objective: The aim of this study was to understand the nature of the overall experiences of a child who has a brother or sister with cancer. Methods: Searches of CINAHL, MEDLINE/PubMed, Science Direct, Scopus, Eric, and Chinese electronic periodical services identified 10 qualitative studies that were published between 1960 and 2013. An appraisal of the primary studies was carried out using the Joanna Briggs Institute Qualitative Assessment and Review Instrument. Results: Siblings of children with cancer were found to have experienced 4 themes: (1) the disintegration of life, (2) marginalization within their family relationships, (3) self-transcendence during the normalization of family relationships, and (4) maintenance of family integrity and family normality. Conclusions: Siblings of children with cancer experience a great deal of chaos in their family life, and this affects their self-esteem and family intimacy. Being with the sick child may help siblings understand the sick child’s suffering and experiences. Implications for Practice: The findings of this review provide evidence to help health professionals to assess the needs of the siblings to enhance their sense of self within the family. Providing the siblings with suitable resources should result in better adjustment.
EXPANDED DIMENSIONS OF THE PURPOSES AND USES OF PERFORMANCE APPRAISAL

This paper attempts to develop an understanding of performance appraisal (PA) and to identify inconsistencies in its purposes and uses through an analysis of previous studies. The paper explores the purposes and uses of PA in the literature and devises a scheme for classifying the practice of PA into four categories ‐ administrative, developmental, strategic, and role definition. This work was done to expand our understanding of performance appraisal and to highlight its uses in connection with other human resource management and development functions. The study finds that previous researchers devoted the most attention to PA conducted for administrative purposes, followed by PA for developmental purposes; the strategic category of PA was studied somewhat, whereas PA for purposes of role definition was almost ignored. The author offers a full-scale inventory of the purposes and uses of PA for researchers, performance raters and ratees. The study proposes that raters need to focus on the broader dimensions of PA, not simply its administrative functions.
Earnings management through accrual-based analysis : Case study: Stockmann Oy Abp 2005-2014

Earnings management emerges from accounting discretion that managers allowed to decide for company. Earnings management is extremely hard to detect and there has not been an ultimate method to detect earning management thoroughly. The thesis seeks to provide general knowledge about earnings management and attempts to apply certain theories and accruals models proposed by researchers (e.g. Jone 1991, Spohr 2004 and Friedlan 1994) to the case study of Stockmann Oy Abp. The literature review is collected from books and major studies (e.g. articles, journals, and working paper) by experts from the field. In the case study, the author decided to conduct an analysis to detect signs of earnings management of Stockmann Oy Abp during financial year 2005-2014 through accruals-based analysis. First of all, the author looks into total accruals and discretionary accruals level over 10 year period. Then based on cash flow analysis, the author reasons her choice of further analysis of financial year 2007-2010. The result showed that total accruals of Stockmann fluctuated widely over 10-year period, and discretionary accruals estimation indicated that during fiscal year 2006-2014, managers have deliberately increased/decreased earnings. In addition, from cash flow approach, financial year 2007-2010 were bought into further analysis. However, detailed break-down of financial statements showed that the divergence in trends of operating cash flows and net income mostly was the result from expansion projects company employed. In addition, manager‟s incentive to deflate earnings is not strong enough to justify author‟s suspicion. In a nutshell, the author could not find any indication of earnings management through accrual analysis based on information on consolidated financial statements provided by the company. However, the result contains some limits and is open to further discussion.
Cancer risk among statin users: A population‐based cohort study

Hydroxymethylglutaryl‐CoA reductase inhibitors (statins) have been linked with potential chemopreventive effects; however, the data are conflicting. We conducted a population‐based cohort study using data from the Prescription Database of North Jutland County and the Danish Cancer Registry for the period 1989–2002. In a study population of 334,754 county residents, we compared overall and site‐specific cancer incidence among 12,251 statin users (≥2 prescriptions) with cancer incidence among nonusers and users of other lipid‐lowering drugs (n = 1,257). Statistical analyses were based on age‐standardization and Poisson regression analysis, adjusting for age, gender, calendar period and use of NSAIDs, hormone replacement therapy and cardiovascular drugs. We identified 398 cancer cases among statin users during a mean follow‐up period of 3.3 years (range 0–14 years). The age‐ and gender‐standardized incidence rates of cancer overall were 596 per 100,000 person‐years among statin users, 645 per 100,000 person‐years among nonusers and 795 per 100,000 person‐years among users of other lipid‐lowering drugs. Adjusted rate ratios for cancer overall among statin users were 0.86 (95% CI, 0.78–0.95) compared to nonusers and 0.73 (95% CI, 0.55–0.98) compared to users of other lipid‐lowering drugs. No significantly increased or decreased rate ratios were observed for any of the studied site‐specific cancers (liver, colorectum, lung, breast, prostate, female genital organs and lymphatic and haematopoietic tissue), but most estimates tended to be less than 1.0. Stratification by duration of follow‐up or number of prescriptions revealed no clear trends. In summary, individuals prescribed statins experienced a slightly reduced cancer incidence compared to population controls of nonusers and users of other lipid‐lowering drugs. Larger and longer‐term studies are needed to determine the potentially protective effect of statin use on cancer development. © 2004 Wiley‐Liss, Inc.
On the max‐cut of sparse random graphs

We consider the problem of estimating the size of a maximum cut (Max‐Cut problem) in a random Erdős‐Rényi graph on n nodes and ⌊cn⌋ edges. It is shown in Coppersmith et al. that the size of the maximum cut in this graph normalized by the number of nodes belongs to the asymptotic region [c/2+0.37613c,c/2+0.58870c] with high probability (w.h.p.) as n increases, for all sufficiently large c. The upper bound was obtained by application of the first moment method, and the lower bound was obtained by constructing algorithmically a cut which achieves the stated lower bound. In this paper, we improve both upper and lower bounds by introducing a novel bounding technique. Specifically, we establish that the size of the maximum cut normalized by the number of nodes belongs to the interval [c/2+0.47523c,c/2+0.55909c] w.h. p. as n increases, for all sufficiently large c. Instead of considering the expected number of cuts achieving a particular value as is done in the application of the first moment method, we observe that every maximum size cut satisfies a certain local optimality property, and we compute the expected number of cuts with a given value satisfying this local optimality property. Estimating this expectation amounts to solving a rather involved two dimensional large deviations problem. We solve this underlying large deviation problem asymptotically as c increases and use it to obtain an improved upper bound on the Max‐Cut value. The lower bound is obtained by application of the second moment method, coupled with the same local optimality constraint, and is shown to work up to the stated lower bound value c/2+0.47523c . It is worth noting that both bounds are stronger than the ones obtained by standard first and second moment methods. Finally, we also obtain an improved lower bound of 1.36000n on the Max‐Cut for the random cubic graph or any cubic graph with large girth, improving the previous best bound of 1.33773n .