Miracle-dz/UniFAR-FTUs huggingface dataset:
From Brown to Green?

Is one of the advantages of late industrialization the ability to incorporate advanced environmental technology in manufacturing? Under what conditions will this take place? This article examines the case of Thailand's pulp and paper industry, which became among the most technologically advanced in the world in the mid-1990s. It documents the social, political, economic, and environmental conditions of this technological greening, noting its accomplishments and limitations. It analyzes the structure of Thailand's pulp industry, examines an eco-catastrophe involving one firm, and addresses the influence of political turmoil, resource conflicts, and business dynamics on that process. Data were collected through site visits, interviews, correspondence, and archival research in Thailand, Singapore, Australia, and the United States, from 1993 to 1997.
Monolithic integration of pseudo-spin-MOSFETs using a custom CMOS chip fabricated through multi-project wafer service

We demonstrated monolithic integration of pseudo-spin-MOSFETs (PS-MOSFETs) using vendor-made MOSFETs fabricated in a low-cost multi-project wafer (MPW) product and lab-made magnetic tunnel junctions (MTJs) formed on the topmost passivation film of the MPW chip. The tunneling magnetoresistance (TMR) ratio of the fabricated MTJs strongly depended on the surface roughness of the passivation film. Nevertheless, after the chip surface was atomically flattened by SiO2 deposition and successive chemical-mechanical polish (CMP) process, the fabricated MTJs on the surface exhibited a sufficiently large TMR ratio (> 140 %) adaptable to the PS-MOSFET application. The implemented PS-MOSFETs showed clear modulation of the output current controlled by the magnetization configuration of the MTJs, and a maximum magnetocurrent ratio of 90 % was achieved. These magnetocurrent behaviors were quantitatively consistent with those predicted by HSPICE simulations. The developed integration technique using a MPW CMOS chip would also be applied to monolithic integration of CMOS devices/circuits and other various functional devices/materials, which would open the door for exploring CMOS-based new functional hybrid circuits.
Serum carbohydrate antigen 125 concentration as a superior predictor for serosal effusion at diagnosis and a prognostic factor in diffuse large B-cell lymphoma.

BACKGROUND Carbohydrate antigen 125 (CA-125) is one of the most common used tumor biomarkers in clinical practice. Previous studies showed an association of increased CA-125 levels with advanced characteristics and inferior outcome in non-Hodgkin lymphoma. OBJECTIVE To identify the clinical significance of CA-125 in diffuse large B-cell lymphoma (DLBCL). METHODS We retrospectively analyzed 181 patients with DLBCL with measured serum CA-125 concentration at diagnosis and follow-ups during the courses. Clinical significance of CA-125 was evaluated by assessing the association between CA-125 levels and clinical characteristics. RESULTS CA-125 levels on admission were positively correlated with serum lactate dehydrogenase, β2-microglobulin (β2-MG), serum ferritin (SF) and cavity effusion, while negatively correlated with serum albumen (ALB). During the courses, CA-125 levels were positively correlated with β 2-MG, SF and effusion, and negatively correlated with ALB. A better correlation between effusion and CA-125 levels was observed. Using a cut-off value > 50.39 U/ml gave a sensitivity of 73.8% and a specificity of 92.1% for the indication of effusion at diagnosis, while during the courses the sensitivity was much lower. On the prognostic role of CA-125, we found prognostic relevance on progression-free survival (PFS) but not on overall survival (OS). CONCLUSIONS Our study revealed limited usefulness of CA-125 concentration at diagnosis and follow-ups in DLBCL.
Multi-Frequency Modular Testing of SoCs by Dynamically Reconfiguring Multi-Port ATE

With the debut of a new class of multi-port ATE (e.g., Agilent 93000 series), there is a pressing need for test planning methods to fully adapting SoC test framework design to the new concurrent test capabilities and fulfil emerging demands of high-speed testing. In this paper, we propose a new test planning strategy that addresses multi-frequency SoC testing by dynamically reconfiguring ATE ports. The system integrators on-the-fly group pins into virtual ports while ATE ports simultaneously drive the testing of a set of cores at multiple independent clock domains. An effective and efficient system optimization technique is developed to manage test resources and improve test efficiency for modern complex SoC designs.
How Aging and Intergeneration Disparity Influence Consumption Inequality in China

Concurrent with market economic reforms, China is facing an increasing income gap and an aging population. The question addressed in the present paper is how much aging contributes to the rising disparity in consumption. Based on the model established by Ohtake and Saito (1998), our study shows that cohort effects contribute close to 60 percent of the rising consumption inequality, while approximately 10 percent is the result of aging. The growth of aggregate consumption inequality caused by the cohort effect has various implications. Strengthening the redistribution system, especially the tax system, may enable the economy to avoid further increases in income inequality.
A first-principles model for anomalous segregation in dilute ternary tungsten-rhenium-vacancy alloys

The occurrence of segregation in dilute alloys under irradiation is a highly unusual phenomenon that has recently attracted attention, stimulated by the interest in the fundamental properties of alloys as well as by their applications. The fact that solute atoms segregate in alloys that, according to equilibrium thermodynamics, should exhibit full solubility, has significant practical implications, as the formation of precipitates strongly affects physical and mechanical properties of alloys. A lattice Hamiltonian, generalizing the so-called ‘ABV’ Ising model and including collective many-body inter-atomic interactions, has been developed to treat rhenium solute atoms and vacancies in tungsten as components of a ternary alloy. The phase stability of W–Re-vacancy alloys is assessed using a combination of density functional theory (DFT) calculations and cluster expansion (CE) simulations. The accuracy of CE parametrization is evaluated against the DFT data, and the cross-validation error is found to be less than 4.2 meV/atom. The free energy of W–Re-vacancy ternary alloys is computed as a function of temperature using quasi-canonical Monte Carlo simulations, using effective two, three and four-body interactions. In the low rhenium concentration range (<5 at.%Re), solute segregation is found to occur in the form of voids decorated by Re atoms. These vacancy-rhenium clusters remain stable over a broad temperature range from 800 K to 1600 K. At lower temperatures, simulations predict the formation of Re-rich rhenium–vacancy clusters taking the form of sponge-like configurations that contain from 30 to 50 at. %Re. The anomalous vacancy-mediated segregation of Re atoms in W can be rationalized by analyzing binding energy dependence as a function of Re to vacancy ratio as well as chemical Re–W and Re-vacancy interactions and short-range order parameters. DFT calculations show that rhenium–vacancy binding energies can be as high as 1.5 eV if the rhenium/vacancy ratio is in the range from 2.4 to 6.6. The predicted Re clustering agrees with experimental observations of precipitation in self-ion irradiated W-2% Re alloys and neutron-irradiated alloys containing 1.4 at. %Re.
Differential growth factor content of uterine luminal fluids from large white and prolific Meishan pigs during the estrous cycle and early pregnancy.

Uterine luminal fluids (ULF) from Large White (LW) and prolific Chinese Meishan (MS) gilts were compared with respect to their peptide growth factor content during an estrous cycle and early pregnancy. Insulin-like growth factor-I (IGF-I) was quantitated by RIA; in vitro growth promoting properties of uterine luminal fluid mitogen (ULFM) were measured by [3H]thymidine incorporation into DNA of quiescent AKR-2B fibroblastic cells in culture. Peak concentrations (pg/microgram ULF protein) of IGF-I in ULF of Large White and Meishan gilts, respectively, were: estrous cycle, 9.8 +/- 1.4 (on d 10) and 39.7 +/- 7.8 (on d 12); gestation, 13.1 +/- 3.2 (on d 8 and 10) and 11.9 +/- 2.1 (on d 12), with differences among days (except d 10, P greater than .5) being affected by breed (P less than .10). For both breeds, there was a rapid decline in IGF-I concentrations by d 14 of the cycle and of pregnancy. Uterine luminal fluid mitogen activity was greater (P less than .01) for LW than for MS gilts on d 10 to 14 of an estrous cycle and gestation and diminished in a time-dependent manner in both breeds. No correlation was observed between IGF-I concentrations and uterine weights for either breed. In contrast, a negative correlation between uterine weight and ULFM activity was detected for cyclic (MS: r = -.855, P less than .10; LW: r = -.834, P less than .05) and pregnant (MS: r = -.806, P less than .10; LW: r = -.928, P less than .05) gilts. (ABSTRACT TRUNCATED AT 250 WORDS)
Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.

UNLABELLED There is an urgent need in oncology to link molecular aberrations in tumors with therapeutics that can be administered in a personalized fashion. One approach identifies synthetic-lethal genetic interactions or dependencies that cancer cells acquire in the presence of specific mutations. Using engineered isogenic cells, we generated a systematic and quantitative chemical-genetic interaction map that charts the influence of 51 aberrant cancer genes on 90 drug responses. The dataset strongly predicts drug responses found in cancer cell line collections, indicating that isogenic cells can model complex cellular contexts. Applying this dataset to triple-negative breast cancer, we report clinically actionable interactions with the MYC oncogene, including resistance to AKT-PI3K pathway inhibitors and an unexpected sensitivity to dasatinib through LYN inhibition in a synthetic lethal manner, providing new drug and biomarker pairs for clinical investigation. This scalable approach enables the prediction of drug responses from patient data and can accelerate the development of new genotype-directed therapies. SIGNIFICANCE Determining how the plethora of genomic abnormalities that exist within a given tumor cell affects drug responses remains a major challenge in oncology. Here, we develop a new mapping approach to connect cancer genotypes to drug responses using engineered isogenic cell lines and demonstrate how the resulting dataset can guide clinical interrogation.
Fine‐tuning vascular fate during endothelial–mesenchymal transition

In the heart and other organs, endothelial–mesenchymal transition (EndMT) has emerged as an important developmental process that involves coordinated migration, differentiation, and proliferation of the endothelium. In multiple disease states including cancer angiogenesis and cardiovascular disease, the processes that regulate EndMT are recapitulated, albeit in an uncoordinated and dysregulated manner. Members of the transforming growth factor beta (TGFβ) superfamily are well known to impart cellular plasticity during EndMT by the timely activation (or repression) of transcription factors and miRNAs in addition to epigenetic regulation of gene expression. On the other hand, fibroblast growth factors (FGFs) are reported to augment or oppose TGFβ‐driven EndMT in specific contexts. Here, we have synthesized the currently understood roles of TGFβ and FGF signalling during EndMT and have provided a new, comprehensive paradigm that delineates how an autocrine and paracrine TGFβ/FGF axis coordinates endothelial cell specification and plasticity. We also provide new guidelines and nomenclature that considers factors such as endothelial cell heterogeneity to better define EndMT across different vascular beds. This perspective should therefore help to clarify why TGFβ and FGF can both cooperate with or oppose one another during the complex process of EndMT in both health and disease. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
B-vitamins, genotype and disease causality*

Despite a great deal of research effort there is still considerable uncertainty surrounding the importance of the B-vitamins in health and disease. This continuing uncertainty is partly a result of the difficulty of measuring intake, confounding in observational studies and the very large numbers required to evaluate primary prevention in randomised controlled trials. Consequently, genetic data are increasingly being used to infer nutritional effects on health and even in the formulation of nutrition policy using the approach of ‘mendelian randomisation’. Genetic information has already contributed greatly to the understanding of B-vitamin metabolism and the heterogeneity of responses to intake. It has the potential to provide further nutritional insights and to assist in the elucidation of causal mechanisms, but it is important that genetic data is not viewed as an alternative to nutritional information, both are necessary when addressing nutritional problems. Similarly, the interpretation of nutrient and biomarker status in some experimental designs may require knowledge of genotype. Formal tests of gene–gene and gene–nutrient interaction are of limited value in nutritional studies and the formulation of policy. Graphical representation of diet–genotype–health data greatly assists in the elucidation of the nature of genetic effects, their interaction with nutrition and the implications for nutrition policy.
Public support for tourism SMEs in peripheral areas: The arjeplog project, northern sweden

Within the European Union, the tourism issues facing many peripheral areas are similar to those elsewhere in the world. Beginning in the late 1980s, the emphasis of thinking in the Union moved away from large automatic grants to attract inward investment projects, towards small firms and indigenous development. As party to this thinking, tourism SMEs have been assigned an important role in the process of regional convergence. While investment subsidies remain a key instrument, they have been supplemented by technical support to tailor assistance to the needs of the individual firm. The latter aspect is an important plank in Swedish regional policy, which sees investing in human competencies as the core to innovative development at the local level. This paper examines the progress and the outcomes of a four-year programme to upgrade the level of business skills in eight tourism SMEs, which are located in the sparsely populated regions of northern Sweden.
Factors involved in long-term efficacy of deep brain stimulation of the thalamus for essential tremor.

OBJECT Although nucleus ventralis intermedius stimulation has been shown to be safe and efficacious in the treatment of essential tremor, there is a subset of patients who eventually lose benefit from their stimulation. Proposed causes for this phenomenon include tolerance, disease progression, and suboptimal location. The goal of this study was to assess the factors that may lead to both stimulation failure, defined as loss of meaningful tremor relief, and less satisfactory outcomes, defined as leads requiring voltages>3.6 V for effective tremor control. METHODS The authors present their clinical outcomes from 31 leads in 27 patients who had effective tremor control for >1 year following nucleus ventralis intermedius stimulation. All patients postoperatively had a mean decrease in both the writing and drawing subscales of the Fahn-Tolosa-Marin Tremor Rating Scale (p<0.001). RESULTS After a mean follow-up of 40 months, 22 patients continued to have tremor control with stimulation. Four patients eventually lost efficacy of their stimulation at a mean of 39 months. There was no difference in age, duration of disease, or disease severity between the groups. Examination of perioperative factors revealed that suboptimal anteroposterior positioning as evidenced on intraoperative fluoroscopy occurred significantly more frequently in patients with stimulation failure (p=0.018). In patients with less satisfactory outcomes, no difference was seen between group demographics. Fluoroscopy again revealed suboptimal positioning more frequently in these patients (p=0.005). CONCLUSIONS This study provides further evidence that suboptimal lead position in combination with disease progression or tolerance may result in less satisfactory long-term outcomes.
Capital Structure – Does Ownership Structure Matter? Theory and Indian Evidence

Purpose - Based on the agency theory, the purpose of this paper is to theoretically argue and empirically investigate how ownership structure impacts the capital structure of the listed mid-cap companies in India and whether the capital structure as exogenous variable has a role in determining ownership structure as well. Design/methodology/approach - Simultaneity between capital structure and ownership structure is checked through Hausman specification test on endogeneity. Fixed effect panel regression model is used to analyze five years of data (2005-2009) on the sample units, to find the relation between leverage and ownership structure after controlling for profitability, risk, tangibility, growth and size. Findings - Empirical results on Indian firms suggest that the ownership structure does impact capital structure but not the vice versa. Consistent with theoretical prediction empirical results reveal that the leverage is positively related to concentrated shareholding and has a negative relation with diffuseness of shareholding after controlling for profitability, risk, tangibility, growth and size. The findings are consistent with “managerial entrenchment hypothesis” and “pecking order theory” of capital structure. Practical implications - The findings of the paper will enable the practitioners and analysts to understand as to why, in the bank and financial institution-dominated debt financing system in India, leverage is closely associated with concentrated ownership pattern and why retained earning is a preferred vehicle of financing for the firms with diffused shareholding. Originality/value - The results of the study enrich the literature on capital structure, agency cost and corporate governance issues in several ways.
Mould specific IgG antibodies connected with sinusitis in teachers of mould damaged school: a two-year follow-up study.

OBJECTIVES The aim of this study was to describe the relationship between mould exposure induced by moisture damage and mould specific immunoglobulin G antibodies to 20 common mould species and their association with respiratory diseases. MATERIALS AND METHODS Mould specific immunoglobulin G (IgG) antibodies were monitored in teachers in a follow-up after an extensive mould remediation process in school buildings. IgG antibodies to 20 different microbes were determined from the sera of 26 teachers (19 exposed and 7 references) by enzyme-linked immunosorbent assay (ELISA). The serum samples were drawn twice, firstly at the completion of the remediation in the spring of 1997 and secondly, two years later in the spring of 1999. Health data was collected with self-administered questionnaires. RESULTS No statistical differences were found in the overall concentrations of 20 mould-specific IgG-antibodies between the study and control groups at the beginning of the study. An association between sinusitis and elevated mould-specific IgG-levels forAspergillus fumigatus, Aspergillus versicolor, Aureobasidium pullulans, Chaetomium globosum, Cladosporium cladosporioides, Phialophora bubakii, Rhodotorula glutinis, Sporobolomyces salmonicolor, Stachybotrys atra, and Tritirachium roseum was found in the study group. CONCLUSIONS In a two-year follow-up the total concentration of the IgG antibodies for Tr. toseum was lower at the end than at the beginning of the follow-up and this remained significant for the group of teachers with sinusitis. The decrease in mould specific IgG to Cl. cladosporioides, Geotrichum candidum, Ph. bubakii and Rhizopus nigricans was associated with bronchitis. According to our knowledge, this is the first study in which the association between elevated mould specific IgG antibodies and sinusitis was found in the school environment.
Pathohistological Subtype Predicts Survival in Patients With Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas

Objective: To investigate different subtypes of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas and their prognostic value. Background: IPMNs of the pancreas are estimated to have a better prognosis than pancreatic ductal adenocarcinomas (PDACs). In addition to the different growth types (ie, main duct vs. branch duct types), the histological subtypes of IPMNs (ie, intestinal, pancreatobiliary, gastric, and oncocytic type) are prognostically relevant. These subtypes can be characterized by different mucin (MUC) expression patterns. In this study, we analyzed the IPMNs from 2 pancreatic cancer referral centers by correlating the MUC expression, histological subtype, and clinical outcome. Methods: We re-evaluated all resections due to a pancreatic tumor over a period of 15 years. Cases with IPMNs were identified, and the subtypes were distinguished using histopathological analysis, including the immunohistochemical analysis of MUC (ie, MUC1, MUC2, and MUC5AC) expression. Furthermore, we determined clinical characteristics and patient outcome. Results: A total of 103 IPMNs were identified. On the basis of the MUC profile, histopathological subtypes were classified into the following categories: intestinal type [n = 45 (44%)], pancreatobiliary type [n = 41 (40%)], gastric type [n = 13 (12%)], and oncocytic type [n = 4 (4%)]. The following types of resections were performed: pancreatic head resections [n = 77 (75%)], tail resections [n = 16 (15%)], total pancreatectomies [n = 5 (5%)], and segment resections [n = 5 (5%)]. The 5-year survival of patients with intestinal IPMNs was significantly better than pancreatobiliary IPMNs (86.6% vs. 35.6%; P < 0.001). The pancreatobiliary subtype was strongly associated with malignancy [odds ratio (OR): 6.76], recurrence (P < 0.001), and long-term survival comparable with that of PDAC patients. Conclusions: Evaluation of IPMN subtypes supports postoperative patient prognosis prediction. Therefore, subtype differentiation could lead to improvements in clinical management. Potentially identifying subgroups with the need for adjuvant therapy may be possible.
CROSS‐COUNTRY EVIDENCE ON LONG‐RUN GROWTH AND INFLATION

While inflation is generally inversely related to growth, the author shows that estimates of the relationship suffer two robustness problems which plague a variety of model specifications. First, growth-inflation results are highly sensitive to modifications to the country sample, limited from the start to low- and moderate-inflation countries. Second, results are also sensitive to modifications in the time period of analysis. In conjunction with the regression specification sensitivity documented by Ross Levine and David Renelt (1992), these results should further discourage the practice of quantifying inflation's effects with cross-country growth regressions. Copyright 1997 by Oxford University Press.