Miracle-dz/UniFAR-FTUs huggingface dataset:
The Importance of the Task in Analyzing Expert Judgment

Abstract The accuracy of judgmental forecasts of temperature and precipitation was analyzed. In contrast to the findings of many studies of expert judgment and forecasting, forecasts were highly accurate and forecaster agreement was high. Human forecasters performed better than an operational forecasting model and about the same as a linear regression model. Differences between temperature and precipitation forecasts could be predicted from differences between the tasks. In general, differences between tasks were much greater than differences between forecasters. Task predictability was an excellent indicator of forecast accuracy. The characteristics of the environment for forecasting temperature and precipitation that contribute to accuracy include high-quality information and the availability of "guidance" based on a computer model. It is concluded that an understanding of the properties of the task is essential for understanding the accuracy of expert judgment.
Blinded clinical evaluation of positron emission tomography for diagnosis of probable Alzheimer's disease

We evaluated the sensitivity and specificity of positron emission tomography for diagnosis of probable Alzheimer's disease under conditions similar to those encountered in the routine clinical practice of nuclear medicine. We obtained tomographic images of regional cerebral blood flow from three groups of subjects: (1) 13 subjects, ages 69 to 84, who had probable Alzheimer's disease diagnosed by validated clinical criteria; (2) 15 subjects, ages 57 to 77, who had Parkinson's disease without dementia; and (3) 11 subjects, ages 65 to 83, who were normal. Three blinded reviewers, who had not previously seen the images, categorized them as normal, bilateral temporoparietal flow defects typical of Alzheimer's disease, or other abnormality. Consensus interpretation demonstrated sensitivity of 0.38 (5/13) and specificity of 0.88 (23/26) for identifying patients with probable Alzheimer's disease. Thus, the criterion of bilateral temporoparietal reduction in cerebral blood flow used in this study did not have sufficient sensitivity to be of clinical value. While other criteria may be developed to improve diagnostic accuracy, clinical utility can be established only by testing for validity in patients with a full spectrum of complicating neurologic and psychiatric conditions for whom diagnosis is uncertain and who are then followed longitudinally to determine clinical outcome or pathologic findings.
Factors Affecting the Accurate Prediction of Iron Losses in Electrical Machines

A model of core losses, in which the hysteresis coefficients are variable with the frequency and induction (flux density) and the eddy-current and excess loss coefficients are variable only with the induction, is proposed. A procedure for identifying the model coefficients from multi-frequency Epstein tests is described and examples are provided for three typical grades of non grain-oriented laminated steel suitable for electric motor manufacturing. Over a wide range of frequencies between 20 Hz and 400 Hz and inductions from 0.05 T up to 2 T the new model yielded much lower errors for the specific core losses than conventional models. The applicability of the model for electric machine analysis is also discussed and examples from an interior permanent and an induction motor are included
Opposite‐Sex Twins and Adolescent Same‐Sex Attraction1

The etiology of human same‐sex romantic attraction is generally framed in terms of (1) social influences, (2) genetic influences, or (3) hormonal influences. In this article, we show that adolescent males who are opposite‐sex twins are twice as likely as expected to report same‐sex attraction; and that the pattern of concordance (similarity across pairs) of same‐sex preference for sibling pairs does not suggest genetic influence independent of social context. Our data falsify the hormone transfer hypothesis by isolating a single condition that eliminates the opposite‐sex twin effect we observe—the presence of an older same‐sex sibling. We also consider and reject a speculative evolutionary theory that rests on observing birth‐order effects on same‐sex orientation. In contrast, our results support the hypothesis that less gendered socialization in early childhood and preadolescence shapes subsequent same‐sex romantic preferences.
Time Complexity Analysis of Support Vector Machines (SVM) in LibSVM

Support Vector Machines (SVM) is one of machine learning methods that can be used to perform classification task. Many researchers using SVM library to accelerate their research development. Using such a library will save their time and avoid to write codes from scratch. LibSVM is one of SVM library that has been widely used by researchers to solve their problems. The library also integrated to WEKA, one of popular Data Mining tools. This article contain results of our work related to complexity analysis of Support Vector Machines. Our work has focus on SVM algorithm and its implementation in LibSVM. We also using two popular programming languages i.e C++ and Java with three different dataset to test our analysis and experiment. The results of our research has proved that the complexity of SVM (LibSVM) is O(n3) and the time complexity shown that C++ faster than Java, both in training and testing, beside that the data growth will be affect and increase the time of computation.
The curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast cancer cells via STAT3 inhibition

Curcumin, the active component of turmeric, has been shown to protect against carcinogenesis and prevent tumor development in cancer. In our study, we tested the efficacy of a synthetic curcumin analogue, known as hydrazinocurcumin (HC), in breast cancer cells. The results demonstrated that compared to curcumin, HC was more effective in inhibiting STAT3 phosphorylation and downregulation of an array of STAT3 downstream targets which contributed to suppression of cell proliferation, loss of colony formation, depression of cell migration and invasion as well as induction of cell apoptosis. It was concluded that HC is a potent agent in the inhibition of STAT3 with more favorable pharmacological activity than curcumin, and HC may have translational potential as an effective cancer therapeutic or preventive agent for human breast carcinoma.
Reduced Life Expectancy Model for Effects of Long Term Exposure on Lethal Toxicity with Fish

A model based on the concept of reduction in life expectancy (RLE model) as a result of long term exposure to toxicant has been developed which has normal life expectancy (NLT) as a fixed limiting point for a species. The model is based on the equation (LC50 = a ln(LT50) + b) where a and b are constants. It was evaluated by plotting ln LT50 against LC50 with data on organic toxicants obtained from the scientific literature. Linear relationships between LC50 and ln LT50 were obtained and a Calculated NLT was derived from the plots. The Calculated NLT obtained was in good agreement with the Reported NLT obtained from the literature. Estimation of toxicity at any exposure time and concentration is possible using the model. The use of NLT as a reference point is important since it provides a data point independent of the toxicity data set and limits the data to the range where toxicity occurs. This novel approach, which represents a departure from Haber's rule, can be used to estimate long term toxicity from limited available acute toxicity data for fish exposed to organic biocides.
A Feed-Forward Loop Coupling Extracellular BMP Transport and Morphogenesis in Drosophila Wing

A variety of extracellular factors regulate morphogenesis during development. However, coordination between extracellular signaling and dynamic morphogenesis is largely unexplored. We address the fundamental question by studying posterior crossvein (PCV) development in Drosophila as a model, in which long-range BMP transport from the longitudinal veins plays a critical role during the pupal stages. Here, we show that RhoGAP Crossveinless-C (Cv-C) is induced at the PCV primordial cells by BMP signaling and mediates PCV morphogenesis cell-autonomously by inactivating members of the Rho-type small GTPases. Intriguingly, we find that Cv-C is also required non-cell-autonomously for BMP transport into the PCV region, while a long-range BMP transport is guided toward ectopic wing vein regions by loss of the Rho-type small GTPases. We present evidence that low level of ß-integrin accumulation at the basal side of PCV epithelial cells regulated by Cv-C provides an optimal extracellular environment for guiding BMP transport. These data suggest that BMP transport and PCV morphogenesis are tightly coupled. Our study reveals a feed-forward mechanism that coordinates the spatial distribution of extracellular instructive cues and morphogenesis. The coupling mechanism may be widely utilized to achieve precise morphogenesis during development and homeostasis.
Fundamental study on a novel Transverse Flux Permanent Magnet Linear Machine

The linear machine can achieve linear motion without rotary-to-linear converters, but the low force density has severely limited its applications in high-performance servo systems. Referring to high torque/force density machines, the transverse flux machine (TFM) is an ideal alternative, but the conventional structure of it is very complicated. In this paper, based on the operating principle analysis of the Wehpsilas prototype, a novel concept of TFM is proposed by derivation of it to achieve the linear motion, which is relatively simple to manufacture. Further, the essence of high force density is investigated, and the characteristic of the electromagnetic force is both theoretically analyzed and numerically computed using three-dimensional finite element method. All the above has laid a good foundation for the further study of the transverse flux permanent magnet linear machine.
Screening of dementia in Chinese elderly adults by the clock drawing test and the time and change test.

OBJECTIVES To assess the usefulness, relative ease of administration, and patient acceptance of the clock drawing test as well as the time and change test for detecting dementia in Chinese elderly adults. DESIGN Prospective case-controlled study. SETTING Memory clinic and geriatric clinic of a district hospital, Hong Kong. PARTICIPANTS A convenient sample of 85 subjects aged 65 years or older attending the two clinics during the period from September 2002 to June 2003. MAIN OUTCOME MEASURES The clock drawing test scored according to Lam's method; the time and change test with modification to the making change task; and the Chinese version of the Mini-Mental State Examination. RESULTS Demented subjects were matched with non-demented ones with respect to age, sex, educational level, and co-morbidity status. The clock drawing test had a comparable sensitivity (89.4%) but a lower specificity (47.1%) when compared with that of the Chinese version of the Mini-Mental State Examination (96.0 and 76.5%, respectively). In contrast, the time and change test had a lower sensitivity (62.7%) but higher specificity (94.1%). Both tests took significantly less time to complete than the Chinese version of the Mini-Mental State Examination. All except four subjects completed the clock drawing test while all subjects accepted the time and change test well. CONCLUSIONS The Chinese version of the Mini-Mental State Examination is still the best among the three tests despite the longer time to completion. The clock drawing test may be a good alternative to the Mini-Mental State Examination as an effective screening test for dementia when time does not permit. The time and change test, although time-saving, is not suitable to be used alone because of its low sensitivity.
Plasma hyaluronan and collateral development in patients with coronary artery disease

ObjectiveIn-vivo studies have shown that hyaluronan (HA) can promote angiogenesis and arteriogenesis, which results in accelerated collateral development. This study is aimed at investigating the association between plasma HA levels and the extent of coronary collaterals, in patients with coronary artery disease. MethodsA total of 253 consecutive patients, who underwent coronary angiography, were divided into three groups according to coronary angiograms: normal group, 81 patients with normal coronary angiographic findings; poor collateral group, 98 patients with at least one coronary stenosis of at least 75%, but without visible collateral circulation; good collateral group, 74 patients with at least one coronary stenosis of at least 75% with well-developed collateral circulation. Plasma HA levels were measured by radioimmunoassay. The correlation between HA levels and the extent of coronary collaterals according to the Cohen–Rentrop classification was calculated by cumulative logits models. ResultsPlasma HA levels were 43.71±2.91, 61.77±4.10, and 131.97±11.76 ng/ml, for patients in the normal, poor collateral, and good collateral groups, respectively. The good collateral group had significantly higher plasma HA levels than the poor collateral (P<0.001) and normal group (P<0.001), whereas there was no significant difference between the normal and poor collateral group. HA levels elevated with increasing Rentrop score, and the cumulative logits model showed a strong graded association between plasma HA levels and the collateral Cohen–Rentrop score (odds ratio=1.021, χ2=17.811, 95% confidence interval: 1.011–1.031, P=0.000). ConclusionThis study suggests that elevated plasma HA levels are associated with a significant enhancement in coronary collateralization. HA may serve as a novel potential biomarker for collateral formation in patients with coronary artery disease.
Design and Realization of a Linear Magnetic Gear

This paper describes a 3.25:1 linear magnetic gear which has been designed and prototyped to meet the performance requirements of an aerospace application. It has been shown that the force capability of the linear magnetic gear is very sensitive to the spacing between the pole-piece rings and that a 5% reduction in the distance between pole pieces may result in a 30% decrease in force transmission capability. It has also been shown that for a given output stroke requirement, in order to maximize volumetric force density, magnetic designs with large airgap diameters and shorter high-speed armature axial lengths would be preferred.
A fast IP routing lookup scheme for gigabit switching routers

One of the key design issues for the new generation IP routers is the route lookup mechanism. For each incoming IP packet, the IP routing requires to perform a longest prefix matching on the address lookup in order to determine the packet's next hop. This paper presents a fast route lookup mechanism that only needs tiny SRAM and can be implemented in a pipelined skill in hardware. Based on the proposed scheme, the forwarding table is tiny enough to fit in SRAM with very low cost. For example, a large routing table with 40,000 routing entries can be compacted to a forwarding table of 450-470 Kbytes. In the worst case, the number of memory accesses for a lookup is three. When implemented in a pipeline skill in hardware, the proposed mechanism can achieve one routing lookup every memory access. With current 10 ns SRAM, this mechanism furnishes approximately 100 million routing lookups per second. This is much faster than any current commercially available routing lookup schemes.
Can Rescheduling Explain the New Jersey Minimum Wage Studies?

This paper interprets the New Jersey minimum wage studies of Card and Krueger and their critics, Neumark and Wascher, through a scheduling model. The former found an increase in the number of workers in New Jersey fast-food restaurants after the state minimum wage was increased, while the latter found a decline in the total payroll hours of New Jersey restaurants. The scheduling model predicts that firms will substitute workers for hours per worker after a wage increase, which is consistent with both studies. Evidence from a subset of restaurants that reported both workers and hours data to Neumark and Wascher supports this interpretation. The New Jersey minimum wage appears to have redistributed income effectively to the targeted population by raising wages and reducing weekly hours per worker by just over one hour without causing any job loss.
The Value of Traffic Bifurcation in Multi-Granular Optical Networks

This paper explores the benefits of incorporating the demand-bifurcation feature into the design and planning process of the multi-granular optical network under the fiber-scarce situation. Our simulation results demonstrate that the bifurcation of demands at all traffic granularity levels can only be beneficial provided that the traffic pattern is uniform and both the traffic intensity and network physical connectivity are high.
A comparison of two surgical approaches in functional neurosurgery: individualized versus conventional stereotactic frames

Abstract Object: The individualized Starfix® miniframe belongs to a new generation of stereotactic systems enabling high-precision electrode placement with considerably better time-efficiency in deep brain stimulation (DBS). We evaluated the usability and reliability of this novel technique in patients with idiopathic Parkinson’s disease (IPD) and compared surgical and clinical results with those obtained in a historical group in which a conventional stereotactic frame was employed. Methods: Sixty patients underwent surgery for implantation of DBS electrodes in the subthalamic nucleus. In 31 of them (group I) a conventional Zamorano-Dujovny frame was used and in 29 of them (group II) a Starfix® miniframe was used. Image fusion of preoperatively acquired 3D T1w and T2w 1.5 T MR-image series was used for the targeting procedure. Placement of the test electrodes and permanent electrodes corresponded to standard functional neurosurgery and included microelectrode recording and macrostimulation. Clinical (L-Dopa equivalent dose, United Parkinson's disease rating scale part III) and time for surgical electrode implantation were evaluated postoperatively in a 3-, 6- and 12-month follow-up. Results: Twelve months postoperatively, L-Dopa dose was significantly reduced from 685.19 to 205.88 mg/day and from 757.92 to 314.42 mg/day in groups I and II, respectively. A comparable reduction of the LED could be observed 1 year after surgery. Motor function has improved in a significant and identical manner with 59% (group I) and 61% (group II). Besides clinical effects by stimulation therapy there was a significantly reduced surgery time required for electrode implantation using the Starfix® miniframe (group I: 234.1 min, group II: 173.6 min; p < 0.001). Conclusions: Individualized miniframes such as the Starfix® miniframe allow implantation of DBS electrodes in IPD that is equally effective as conventional systems. The time efficiency achieved in surgery using of the Starfix® system helps to minimize patients' discomfort during DBS surgery.
Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes

Human immunodeficiency virus type 1 (HIV-1) infection has been associated with an increase in the binding of the transcription factor NF-kappa B to its consensus sequence in the viral promoter. Using cultures of primary human fetal astrocytes, we show that exogenous HIV-1 Tat protein, which has been demonstrated to be released from infected cells, is associated with an increase in the binding of this transcription factor to an HIV-1 long terminal repeat kappa B sequence. This effect occurs rapidly and is independent of new protein synthesis. We also demonstrate that extracellular Tat protein is associated with an increase in protein kinase C activity. If Tat functions similarly in other cell types, such findings could relate to some of this protein's previously described physiological effects. These effects include Tat's ability to upregulate the synthesis of specific cytokines and to act as a growth factor.
Cost-Optimized Resource Provision for Cloud Applications

With an increasing number of cloud providers starting to offer virtual resource leasing services, application providers have more choices when requiring resources. But how to achieve the most cost-optimized resource solution is still a challenge. To address this problem, we propose a cost optimized resource provision approach which achieves the cost saving target for application providers. In our approach, we figure out the projection between workload and VM amount according to predicted workload. By exploiting pricing policies of existing cloud providers, our approach presents a hybrid resource provision solution, which involve instances of different prices and leasing durations. The experiment results demonstrate that our approach achieves the cost-saving goal with few SLA violations and little resource waste.
Activated H-ras rescues E1A-induced apoptosis and cooperates with E1A to overcome p53-dependent growth arrest

The adenovirus E1A oncogene products stimulate DNA synthesis and cell proliferation but fail to transform primary baby rat kidney (BRK) cells because of the induction of p53-mediated programmed cell death (apoptosis). Overexpression of dominant mutant p53 (to abrogate wild-type p53 function) or introduction of apoptosis inhibitors, such as adenovirus E1B 19K or Bcl-2 oncoproteins, prevents E1A-induced apoptosis and permits transformation of BRK cells. The ability of activated Harvey-ras (H-ras) to cooperate with E1A to transform BRK cells suggests that H-ras is capable of overcoming the E1A-induced, p53-dependent apoptosis. We demonstrate here that activated H-ras was capable of suppressing apoptosis induced by E1A and wild-type p53. However, unlike Bcl-2 and the E1B 19K proteins, which completely block apoptosis but not p53-dependent growth arrest, H-ras expression permitted DNA synthesis and cell proliferation in the presence of high levels of wild-type p53. The mechanism by which H-ras regulates apoptosis and cell cycle progression is thereby strikingly different from that of the E1B 19K and Bcl-2 proteins. BRK cells transformed with H-ras and the temperature sensitive murine mutant p53(val 135), which lack E1A, underwent growth arrest at the permissive temperature for wild-type p53. p53-dependent growth arrest, however, could be relieved by E1A expression. Thus, H-ras alone was insufficient and cooperation of H-ras and E1A was required to override growth suppression by p53. Our data further suggest that two complementary growth signals from E1A plus H-ras can rescue cell death and thus permit transformation.
Measuring Video Quality on Full Scalability of H.264/AVC Scalable Video Coding

In heterogeneous network environments, it is mandatory to measure the grade of the video quality in order to guarantee the optimal quality of the video streaming service. Quality of Service (QoS) has become a key issue for service acceptability and user satisfaction. Although there have been many recent works regarding video quality, most of them have been limited to measuring quality within temporal and Signal-to-Noise Ratio (SNR) scalability. H.264/AVC Scalable Video Coding (SVC) has emerged and has been developed to support full scalability. This includes spatial, temporal, and SNR scalability, each of which shows different visual effects. The aim of this paper is to define and develop a novel video quality metric allowing full scalability. It focuses on the effect of frame rate, SNR, the change of spatial resolution, and motion characteristics using subjective quality assessment. Experimental results show the proposed quality metric has a high correlation to subjective quality and that it is useful in determining the video quality of SVC.