Miracle-dz/UniFAR-FTUs huggingface dataset:
Research on Robot Monocular Vision-Based 6DOF Object Positioning and Grasping Approach Combined With Image Generation Technology

To address the challenges related to poor positioning accuracy and high usage cost of 6DOF visual measurement systems in industrial settings, this paper presents a monocular vision-based robot vision guidance approach. The goal is to address the issues of expensive 6DOF pose measurement and limited measurement robustness when robots need to manipulate metal objects in industrial environments. The proposed approach enables precise and robust measurement of the 6DOF pose of the target workpiece. The approach integrates two main algorithms: a virtual reality-based image data enhancement algorithm and a 6DOF pose measurement algorithm that combines a multi-keypoint detection model and the Efficient Perspective-n-Points (EPnP) algorithm. The image data enhancement algorithm enhances the data of small-sample industrial objects using image enhancement techniques. This improves the robustness of the detection model by mitigating the challenges of high-cost image acquisition and long acquisition time associated with industrial objects. On the other hand, the 6DOF pose measurement algorithm performs the pose measurement of the target workpiece using a single image, enabling cost-effective 6DOF pose measurement by utilizing only a monocular camera. Experimental results demonstrate that the proposed method achieves measurement errors of 4.21% in the X direction, 2.94% in the Y direction, and 0.39% in the Z direction of the target workpiece. These results highlight the effectiveness of the proposed approach in achieving accurate and reliable pose measurement.
UvA-DARE (Digital Academic Repository) UvA@Work - Customer Agriculture Order - Mid-Term Report

The goal of the UvA@Work team is to demonstrate that the KUKA youBot platform is capable of performing a Professional Task as deﬁned in the Field Robot event 2012. This task speciﬁes a robot that retrieves a ﬂower as ordered by a customer. For this task three key components are required: Human Robot Interaction, Path Planning and Manipulation.
The Open Journal of Occupational Therapy Rehabilitation of the Upper Extremity after Stroke: Current Practice as a Guide for Curriculum Credentials Display Rehabilitation of the Upper Extremity after Stroke: Current Practice as a Guide for Curriculum

Stroke is the leading cause of disability in the United States and a top diagnosis for occupational therapy (OT) services among neurological conditions. Academic programs teach OT students neurological frames of reference (FORs) to provide a foundation for future practice. To meet accreditation standards, entry-level curricula must reflect current practice and evidence-based interventions. A survey of OT practitioners working in upper extremity stroke rehabilitation was conducted to investigate current clinical practice in a variety of treatment settings. Survey questions probed the use of motor rehabilitation techniques exclusive to one of six neurological FORs: Brunnstrom, Constraint-induced Movement Therapy, Neurodevelopmental Treatment, Proprioceptive Neuromuscular Facilitation, Rood, and Task-Oriented. Responses from 167 OT professionals indicated interventions representing all six FORs are currently being utilized in stroke rehabilitation. Techniques from the Task-Oriented and Neurodevelopmental Treatment approaches were used most frequently; however, the Rood–based techniques were used much less than interventions from the other FORs. No single neurological approach was found to dominate practice regardless of the number of years of experience in stroke rehabilitation or years since graduation from an entry-level program. A majority of participants appear to employ techniques from multiple approaches frequently, suggesting contemporary OT practice in upper extremity stroke rehabilitation is eclectic in nature.of-the-upper-extremity-after-stroke OJOT is excited to partner with MedBridge to offer online CEUs through Breakouts – short, evidence-based video interviews featuring OJOT authors. Click here to learn more about this unique opportunity for discussions on hot topics in OT by leading researchers. to the preparation of the study which was completed while they were students in the Rockhurst MOT the OTs at KU Medical Center who previewed the survey; and the 2011 Neurological Theories Capstone group who prepared the pilot study. The progress of modern science and health care is rapid and multi-directional. It is incumbent upon the occupational therapy (OT) profession to keep its practitioners as up-to-date as possible in order to provide appropriate and effective care for clients of all ages and needs. One challenge brought on by the dynamic nature of health care services is the education of new OT practitioners that is in step with current advancements yet remains true to the core values and methods developed during a century-old history of care. Academic institutions and clinical fieldwork sites must prepare entry-level occupational therapists and occupational therapy assistants to become competent generalists (ACOTE, 2012). OT program accreditation standards include a mandate to teach intervention planning that …
Implementation of the Russian Table of Ranks During the Eighteenth Century

Peter the Great in 1722 introduced an entirely new system of ranking for the government service. His system embodied two marked departures from former practice. It provided for the separation of the civil from the military service, and it promised ennoblement to any commoner who attained a sufficiently high level of rank. A promotional ladder of fourteen steps was established, the eighth step from the top being designated as the one that would confer upon its fortunate possessors the status of nobility (dvorianskoe svanie)—that is, if they did not already enjoy such distinction through birth or royal favor. This system, maintained with modifications until the downfall of the Russian Empire, was officially entitled the Table of Ranks (Tabel' o rangakh). Various principles were expressed in the Table of Ranks, and it is the purpose of this study to discover what meaning they had in eighteenth-century practice. Some principles the government consistently attempted to uphold, some it violated, and in certain cases practices were established that the Table had not dealt with at all. I have concerned myself almost entirely with the civil service and have relied particularly upon legislation of the period as an indicator of administrative developments. An understanding of the fate that befell the Table of Ranks should provide insights into the problems of eighteenthcentury Russian administration. The Table of Ranks contained specialized terminology which was quickly assimilated by government servitors and provided a common and familiar ground of understanding for those interested in public office. The word "rank" (rang) indicated a man's status as determined by his "title" (chin) and "class" (klass). Each of the fourteen steps of the promotional ladder was referred to as a "class. " Within most classes there was more than one title, and each title was originally intended by Peter to describe a distinct office. Similar titles
Adaptation à la sécheresse et création variétale : le cas de l’arachide en zone sahélienne

1 CIRAD (Centre de cooperation internationale en recherche agronomique pour le developpement), TA70/01, Avenue Agropolis, 34398 Montpellier Cedex 5, France 2 Laboratoire d’ecophysiologie moleculaire, UMR 137 Biodiversite des sols, Faculte de Sciences et Technologie, Universite Paris 12, 64 Avenue du General de Gaulle, 94010 Creteil Cedex, France 3 ISRA/CERAAS (Centre d’etude regional pour l’amelioration de l’adaptation a la secheresse), CERAAS, BP 3320, Thies-Escale, Thies, Senegal
Tumorigenesis and Neoplastic Progression The Chemokine Receptor CXCR 4 and the Metalloproteinase MT 1-MMP Are Mutually Required during Melanoma Metastasis to Lungs

From the Department of Cellular and Molecular Physiopathology,* Centro de Investigaciones Biológicas, Madrid, Spain; Animal Facility Unit, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain; Laboratorio de Microbiología Molecular, Hospital Universitario 12 de Octubre, Madrid, Spain; Unidad de Medicina y Cirugía Experimental, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Servicio de Inmuno-Oncología, Hospital Universitario Gregorio Marañón, Madrid, Spain; and the Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Tumorigenesis and Neoplastic Progression A Novel Organotypic Model Mimics the Tumor Microenvironment

Carcinoma cell invasion is traditionally studied in three-dimensional organotypic models composed of type I collagen and fibroblasts. However, carcinoma cell behavior is affected by the various cell types and the extracellular matrix (ECM) in the tumor microenvironment. In this study, a novel organotypic model based on human uterine leiomyoma tissue was established and characterized to create a more authentic environment for carcinoma cells. Human tongue squamous cell carcinoma cells (HSC-3) were cultured on top of either collagen or myoma. Organotypic sections were examined by immunohistochemistry and in situ hybridization. The maximal invasion depth of HSC-3 cells was markedly increased in myomas compared with collagen. In myomas, various cell types and ECM components were present, and the HSC-3 cells only expressed ECM molecules in the myoma model. Organotypic media were analyzed by radioimmunoassay, zymography, or Western blotting. During carcinoma cell invasion, matrix metalloprotease-9 production and collagen degradation were enhanced particularly in the myoma model. To evaluate the general applicability of the myoma model , several oral carcinoma, breast carcinoma, and melanoma cell lines were cultured on myomas and found to invade in highly distinct patterns. We conclude that myoma tissue mimics the native tumor microenvironment better than previous organotypic models and possibly enhances epithelial-tomesenchymal transition. Thus, the myoma model provides a promising tool for analyzing the behavior of carcinoma cells. (Am J Pathol 2009, 175:1281–1291; DOI: 10.2353/ajpath.2009.081110)
Tumorigenesis and Neoplastic Progression Mammalian Target of Rapamycin ( mTOR ) Regulates Cellular Proliferation and Tumor Growth in Urothelial Carcinoma

From the Department of Anatomic Pathology,* the Genomic Medicine Institute, the Taussig Cancer Institute, and the Glickman Urological and Kidney Institute, The Cleveland Clinic, Cleveland, Ohio; the Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland; the Department of Urology, University of Virginia, Charlottesville, Virginia; and the Department of Genetics and CASE Comprehensive Cancer Center,** Case Western Reserve University School of Medicine, Cleveland, Ohio
Tumorigenesis and Neoplastic Progression Proepithelin Regulates Prostate Cancer Cell Biology by Promoting Cell Growth , Migration , and Anchorage-Independent Growth

The growth factor proepithelin has recently emerged as an important regulator of transformation in several physiological and pathological systems. In this study, we determined the biological roles of proepithelin in prostate cancer cells using purified human recombinant proepithelin as well as proepithelin-depletion strategies. Proepithelin promoted the migration of androgen-dependent and -independent human prostate cancer cells; androgen-independent DU145 cells were the more responsive. In these cells, proepithelin additionally stimulated wound closure, invasion, and promotion of cell growth in vitro. These effects required the activation of both the Akt and mitogen-activated protein kinase pathways. We have analyzed proepithelin expression levels in different available prostate cancer microarray studies using the Oncomine database and found a statistically significant increase in proepithelin mRNA expression levels in prostate cancers compared with nonneoplastic controls. Notably, depletion of endogenous proepithelin by siRNA and antisense strategies impaired the ability of DU145 cells to grow and migrate after serum withdrawal and inhibited anchorage-independent growth. Our results provide the first evidence for a role of proepithelin in stimulating the migration, invasion, proliferation, and anchorage-independent growth of prostate cancer cells. This study supports the hypothesis that proepithelin may play a critical role as an autocrine growth factor in the establishment and initial progression of prostate cancer. Furthermore, proepithelin may prove to be a useful clinical marker for the diagnosis of prostate tumors. (Am J Pathol 2009, 174:1037–1047; DOI: 10.2353/ajpath.2009.080735)
Tumorigenesis and Neoplastic Progression Oncogenic Role of the E 3 Ubiquitin Ligase NEDD 4-1 , a PTEN Negative Regulator , in Non-Small-Cell Lung Carcinomas

Loss of the PTEN tumor suppressor gene occurs frequently in non-small-cell lung carcinoma (NSCLC), although neither genetic alterations nor epigenetic silencing are significant predictors of PTEN protein levels. Since recent reports implicated neural precursor cell expressed, developmentally down-regulated 4-1 (NEDD4-1) as the E3 ubiquitin ligase that regulates PTEN stability, we investigated the role of NEDD4-1 in the regulation of PTEN expression in cases of NSCLC. Our findings indicate that NEDD4-1 plays a critical role in the development of NSCLC and provides novel insight on the mechanisms that contribute to inactivate PTEN in lung cancer. Immunohistochemical analysis on tissue microarrays containing 103 NSCLC resections revealed NEDD4-1 overexpression in 80% of tumors, which correlated with the loss of PTEN protein (n 98; P < 0.001). Accordingly, adoptive NEDD4-1 expression in NSCLC cells decreased PTEN protein stability, whereas knock-down of NEDD4-1 expression decreased PTEN ubiquitylation and increased PTEN protein levels. In 25% of cases, NEDD4-1 overexpression was due to gene amplification at 15q21. In addition, manipulation of NEDD4-1 expression in different lung cell systems demonstrated that suppression of NEDD4-1 expression significantly reduced proliferation of NSCLC cells in vitro and tumor growth in vivo , whereas NEDD4-1 overexpression facilitated anchorage-dependent and independent growth in vitro of nontransformed lung epithelial cells that lack pRB and TP53 (BEAS-2B). NEDD4-1 overexpression also augmented the tumorigenicity of lung cancer cells that have an intact PTEN gene (NCI-H460 cells). (Am J Pathol 2010, 177:2622–2634; DOI: 10.2353/ajpath.2010.091075)
Tumorigenesis and Neoplastic Progression Podocalyxin EBP 50 Ezrin Molecular Complex Enhances the Metastatic Potential of Renal Cell Carcinoma Through Recruiting Rac 1 Guanine Nucleotide Exchange Factor ARHGEF 7

From the Department of Internal Medicine,* Taipei Medical University-Shuang Ho Medical Center, Taipei; the Departments of Internal Medicine, and Urology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei; the Department of Pathology, National Taiwan University Hospital, Taipei; the Department of Forensic Medicine, National Taiwan University College of Medicine, Taipei; the Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei; and the Department of Pathology, Cathay General Memorial Hospital, Taipei, Taiwan
TUMORIGENESIS AND NEOPLASTIC PROGRESSION Astroprincin ( FAM 171 A 1 , C 10 orf 38 ) A Regulator of Human Cell Shape and Invasive Growth

opyright a 2019 American Society for Inve his is an open access article under the CC B ttps://doi.org/10.1016/j.ajpath. 2018.09. 006 Our group originally found and cloned cDNA for a 98-kDa type 1 transmembrane glycoprotein of unknown function. Because of its abundant expression in astrocytes, it was called the protein astroprincin (APCN). Two thirds of the evolutionarily conserved protein is intracytoplasmic, whereas the extracellular domain carries two N-glycosidic side chains. APCN is physiologically expressed in placental trophoblasts, skeletal and hearth muscle, and kidney and pancreas. Overexpression of APCN (cDNA) in various cell lines induced sprouting of slender projections, whereas knockdown of APCN expression by siRNA caused disappearance of actin stress fibers. Immunohistochemical staining of human cancers for endogenous APCN showed elevated expression in invasive tumor cells compared with intratumoral cells. Human melanoma cells (SKMEL-28) transfected with APCN cDNA acquired the ability of invasive growth in semisolid medium (Matrigel) not seen with control cells. A conserved carboxyterminal stretch of 21 amino acids was found to be essential for APCN to induce cell sprouting and invasive growth. Yeast two-hybrid screening revealed several interactive partners, of which ornithine decarboxylase antizyme-1, NEEP21 (NSG1), and ADAM10 were validated by coimmunoprecipitation. This is the first functional description of APCN. These data show that APCN regulates the dynamics of the actin cytoskeletal and, thereby, the cell shape and invasive growth potential of tumor cells. (Am J Pathol 2019, 189: 177e189; https://doi.org/10.1016/ j.ajpath.2018.09.006)
Tumorigenesis and Neoplastic Progression COX-2 and Prostaglandin EP 3 / EP 4 Signaling Regulate the Tumor Stromal Proangiogenic Microenvironment via CXCL 12-CXCR 4 Chemokine Systems

Hiroshi Katoh,* Kanako Hosono,* Yoshiya Ito,* Tatsunori Suzuki,* Yasufumi Ogawa,* Hidefumi Kubo,* Hiroki Kamata,* Toshiaki Mishima,* Hideaki Tamaki, Hiroyuki Sakagami, Yukihiko Sugimoto, Shuh Narumiya, Masahiko Watanabe, and Masataka Majima* From the Departments of Pharmacology,* Surgery, and Anatomy, Kitasato University, School of Medicine, Sagamihara, Kanagawa; and the Department of Pharmacology, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan
Robust mapping of tropical cyclone wave fields using HF skywave radar

The prospect of obtaining real-time measurements of oceanographic and meteorological conditions over vast areas of the Earth's oceans by means of HF skywave ('over-the-horizon') radar has been the subject of many investigations over the past three decades. The remote sensing information is obtained by interpretation of echoes from the sea surface, whose time-varying geometry imposes a complex modulation on the radar signals. Depending on radar design and ionospheric conditions, a map spanning several million square kilometres may be acquired on a grid with resolution typically 10-20 km in less than 30 minutes. We describe methods developed in the Defence Science and Technology Organisation (DSTO) to overcome, or at least minimise, the deleterious effects of radio interference, disturbed ionospheric propagation conditions, scattering from very rough seas and the intrinsic complications of wave fields generated by intense weather systems. The goal is the integration of these various measures into a fully automated cyclone mapping system.
Tumorigenesis and Neoplastic Progression Aberrant Stratifin Overexpression Is Regulated by Tumor-Associated CpG Demethylation in Lung Adenocarcinoma

We previously have shown the aberrant overexpression of stratifin (SFN, 14-3-3 ) in lung adenocarcinoma. Although SFN is known to facilitate tumor cell proliferation, the mechanism that underlies its aberrant expression has remained unclear. SFN, the downstream target of p53, often has been reported to be hypermethylated and subsequently silenced in certain cancers; however, its hypomethylation-linked reactivation has not yet been validated. In this study, we investigated the DNA methylation status of the SFN promoter region using 8 lung cancer cell lines and 32 specimens of adenocarcinoma tissue. Real-time methylation-specific PCR analysis showed that although both normal lung tissue and adenocarcinoma in situ bore a completely methylated SFN promoter, the promoter region in almost all invasive adenocarcinomas was at least partially methylated. The expression of SFN and its level of methylation were correlated strongly. Furthermore, statistical analysis revealed that the level of methylation became reduced with progression of the pathologic stage, although no clear relationship between methylation level and p53 abnormality was found. These results suggest that methylation-related silencing of SFN occurs in both normal lung tissues and adenocarcinoma in situ, and that demethylation of the SFN promoter participates in the aberrant expression of SFN in invasive adenocarcinoma cells, independently of p53 alteration. This novel finding might be informative for clarifying the mechanism that underlies the progression of early lung adenocarcinoma. (Am J Pathol 2012, 180:1653–1662; DOI: 10.1016/j.ajpath.2011.12.014)
Tumorigenesis and Neoplastic Progression Lack of Fetuin-A ( 2-HS-Glycoprotein ) Reduces Mammary Tumor Incidence and Prolongs Tumor Latency via the Transforming Growth Factor-Signaling Pathway in a Mouse Model of Breast Cancer

The present analyses were done to define the role of fetuin-A (Fet) in mammary tumorigenesis using the polyoma middle T antigen (PyMT) transgenic mouse model. We crossed Fet-null mice in the C57BL/6 background with PyMT mice in the same background and after a controlled breeding protocol obtained PyMT/Fet / , PyMT/Fet / , and PyMT/Fet / mice that were placed in control and experimental groups. Whereas the control group (PyMT/Fet / ) formed mammary tumors 90 days after birth, tumor latency was prolonged in the PyMT/Fet / and PyMT/Fet / mice. The majority of the PyMT/Fet / mice were tumor-free at the end of the study, at approximately 40 weeks. The pathology of the mammary tumors in the Fet-null mice showed extensive fibrosis, necrosis, and squamous metaplasia. The preneoplastic mammary tissues of the PyMT/Fet / mice showed intense phopho-Smad2/3 staining relative to control tissues, indicating that transforming growth factorsignaling is enhanced in these tissues in the absence of Fet. Likewise, p19ARF and p53 were highly expressed in tumor tissues of PyMT/Fet / mice relative to the controls in the absence of Fet. The phosphatidylinositol 3-kinase/Akt signaling pathway that we previously showed to be activated by Fet, on the other hand, was unaffected by the absence of Fet. The data indicate that Fet is a powerful modulator of breast tumorigenesis in this model system and has the potential to modulate breast cancer progression in humans. (Am J Pathol 2010, 177:2635–2644; DOI: 10.2353/ajpath.2010.100177)
Hypoxia, Ion Channels and Glioblastoma Malignancy

The malignancy of glioblastoma (GBM), the most aggressive type of human brain tumor, strongly correlates with the presence of hypoxic areas within the tumor mass. Oxygen levels have been shown to control several critical aspects of tumor aggressiveness, such as migration/invasion and cell death resistance, but the underlying mechanisms are still unclear. GBM cells express abundant K+ and Cl− channels, whose activity supports cell volume and membrane potential changes, critical for cell proliferation, migration and death. Volume-regulated anion channels (VRAC), which mediate the swelling-activated Cl− current, and the large-conductance Ca2+-activated K+ channels (BK) are both functionally upregulated in GBM cells, where they control different aspects underlying GBM malignancy/aggressiveness. The functional expression/activity of both VRAC and BK channels are under the control of the oxygen levels, and these regulations are involved in the hypoxia-induced GBM cell aggressiveness. The present review will provide a comprehensive overview of the literature supporting the role of these two channels in the hypoxia-mediated GBM malignancy, suggesting them as potential therapeutic targets in the treatment of GBM.