Miracle-dz/UniFAR-FTUs huggingface dataset:
Magmatic Hydrothermal Fluids at the Sedimentary Rock-hosted, Intrusion-related Telfer Gold-Copper Deposit, Paterson Orogen, Western Australia: P-T-X Constraints on the Ore Forming Fluids

The Neoproterozoic Telfer deposit, one of Australia’s largest gold-copper deposits is located in the Paterson Orogen. Several highly differentiated calc-alkaline to alkali-calcic peraluminous granites intruded the metasedimentary rocks near (5-20 km) Telfer contemporaneous with structurally controlled gold-copper mineralization. Fluid inclusion assemblages with different fluid inclusion types were identified in samples from a range of different vein types. These inclusion types range from three phase aqueous Laq+Vaq+Shalite, high salinity (≤ 50 wt % NaCl equiv), high temperature (≤ 460°C) inclusions to two phase aqueous or two phase aqueous carbonic, low to moderate salinity (2 - 22 wt % NaCl equiv.), moderate to high temperature (≤ 480°C) fluid inclusions. Fluid inclusion trapping mechanisms, and interpreted precipitation mechanisms for gold and copper include: (1) adiabatic cooling between 450 and 200°C in all veins, and (2) locally, fluid phase separation at around 300°C. The trapping pressure of fluid inclusion assemblages trapped during phase immiscibility was calculated to be approximately 1.5 kbars. For fluid inclusion assemblages that lack evidence for phase immiscibility a pressure, at the temperature of final homogenization, of up to 3 kbars was calculated. This high pressure value is interpreted to be related to local fluid overpressure, as a consequence of fault zone movement, in faults and fractures that localized gold at Telfer. Phase immiscibility and gold precipitation was induced during sharp pressure decrease accompanying fault zone movement. In situ laser ICP-MS analyses of fluid inclusions revealed high trace element contents in all fluid inclusion assemblages. Manganese/Fe ratios of 0.24 is observed. Given the high temperatures and salinities of up to 480°C and 42 wt % NaCl equiv. , Au and Cu were likely transported as chloride complexes. This interpretation is supported by the observation that the highest base metal contents occurs in the highest salinity fluid inclusion. Potassium/Ca ratios of >1 in most assemblages, the high homogenization temperatures (≤ 480°C) in many fluid inclusion assemblages, and the high trace element contents (e.g., Fe, Mg, K, Na) in most of the fluid inclusion assemblages is compatible with involvement of a magmatic hydrothermal fluid during gold-copper mineralization. This fluid was probably derived from the coeval granites in the Telfer area and, thus Telfer is interpreted to be a distal, intrusion-related, metasedimentary rock hosted, gold-copper deposit type. Because of all the arguments mentioned above, Telfer can best be described as an unique intrusion-related, structurally controlled, metasedimentary rock hosted, gold-copper deposit.
Impact of Agronomic Practices on Weed Communities: Fallow Within Tillage Systems

Continuous-cropping conservation tillage systems may provide a viable alternative to the practice of summer fallow; however, concerns have been raised regarding potentially negative changes in weed communities in continuous cropping. Field experiments were established in Saskatchewan at three locations to determine the nature of weed community differences between a crop sequence with and without fallow in zero-, minimum-, and conventional-tillage systems from 1986 to 1990. Weed communities in continuous-cropping treatments tended to have greater total densities and were more similar in composition than crop-fallow treatments. Inclusion or exclusion of fallow within the rotation had a greater impact on weed community composition than did tillage system at Ituna and Waldron, but the reverse was true at Tadmore due to poor crop growth in all tillage systems. Differences in weed community composition were generally characterized by fluctuational changes in species associations. Volunteers of summer-annual crops, such as canola, flax, and barley, were associated with continuous cropping, but other species including perennial weeds, such as Canada thistle, perennial sowthistle, and quackgrass, were not strongly associated with the presence or absence of fallow. The practice of fallowing land to manage weeds may not be necessary.
Coping Resources among Forced Migrants in South Africa: Exploring the Role of Character Strengths in Coping, Adjustment, and Flourishing

This phenomenological qualitative study explored how forced migrants in South Africa cope with violent, traumatic experiences and precarious resettlement conditions. Data came from a larger empirical project examining migration, psychological distress, and coping. In-depth interviews were conducted with 14 refugees and asylum seekers (Mage = 30.27, SDage = 9.27; male = 71.43%) who migrated from five African countries to Durban, South Africa. Despite overwhelming stressors, participants described pathways to transcend victimhood and hardship through engaging character strengths in ways that promote post-traumatic growth. Qualitative analysis revealed five overarching domains: spirituality and religiousness, love and kindness, hope and optimism, persistence and fortitude, and gratitude and thankfulness. Findings are framed within positive existential psychology and dual-factor understandings of mental health, which attend to both human suffering and flourishing. Limitations, future research directions, and clinical and community implications are discussed, with attention to the role of character strengths in adaptive coping and psychological well-being. The intergenerational transmission of strengths is explored as one potential means of buffering intergenerational trauma impacts and promoting family post-traumatic growth.
The utilization of the double focal transformation for sparse data representation and data reconstruction

In many cases, seismic measurements are coarsely sampled in at least one dimension. This leads to aliasing artefacts and therefore to problems in the subsequent processing steps. To avoid this, seismic data reconstruction can be applied in advance. The success and reliability of reconstruction methods are dependent on the assumptions they make on the data. In many cases, wavefields are assumed to (locally) have a linear space–time behaviour. However, field data are usually complex, with strongly curved events. Therefore, in this paper, we propose the double focal transformation as an efficient way for complex data reconstruction. Hereby, wavefield propagation is formulated as a transformation, where one‐way propagation operators are used as its basis functions. These wavefield operators can be based on a macro velocity model, which allows our method to use prior information in order to make the data decomposition more effective. The basic principle of the double focal transformation is to focus seismic energy along source and receiver coordinates simultaneously. The seismic data are represented by a number of localized events in the focal domain, whereas aliasing noise spreads out. By imposing a sparse solution in the focal domain, aliasing noise is suppressed, and data reconstruction beyond aliasing is achieved. To facilitate the process, only a few effective depth levels need to be included, preferably along the major boundaries in the data, from which the propagation operators can be calculated. Results on 2D and 3D synthetic data illustrate the method's virtues. Furthermore, seismic data reconstruction on a 2D field dataset with gaps and aliased source spacing demonstrates the strength of the double focal transformation, particularly for near‐offset reflections with strong curvature and for diffractions.
Unveiling Catecholamine Dynamics in Cardiac Health and Disease: Mechanisms, Implications, and Future Perspectives

Review Unveiling Catecholamine Dynamics in Cardiac Health and Disease: Mechanisms, Implications, and Future Perspectives Wenjing Xiang, Xingyun Wang, Lei Li, Junhui Zeng, Haocheng Lu, and Ying Wang * Department of Pharmacology, School of Medicine, Southern University of Science and TechnologyShenzhen518055China * Correspondence: wangy6@sustech.edu. cn Received: 15 August 2023 Accepted: 21 September 2023 Published: 27 December 2023 Abstract: Catecholamines play a pivotal role in regulating both cardiac physiology and pathology, orchestrating the “Fight-or-flight” response through the activation of sympathetic nervous system (SNS) activation and subsequent stimulation of adrenergic receptor. However, chronic stress and various cardiac diseases can disrupt catecholamine balance, contributing to cardiac dysfunction. The synthesis, release, reuptake, and degradation of catecholamines intricately regulate their concentration. Notably, catecholamine dynamics is markedly altered in heart diseases, including heart failure, myocardial infarction, and arrhythmias. While β‍-adrenergic receptor blockers, which block catecholamines from binding to the adrenergic receptors, are widely used in clinical settings, the potential implication of directly manipulating catecholamine homeostasis for the treatment of cardiac diseases have not been extensively explored. This review provides an overview of catecholaminergic systems, and discusses their intricate synthesis, release, uptake, and metabolism within the heart. Additionally, the review highlights mechanisms underlying cardiac effects of catecholamine dysregulation, including contractile dysfunction, electrical remodeling, and cardiac remodeling. Moreover, the review emphasizes the importance of considering spatiotemporal and sexual heterogeneity in catecholamine dynamics for cardiac precision medicine. In terms of future perspectives, we believe that harnessing genetically encoded fluorescent biosensors to map the heterogenous for real-time imaging of catecholamine dynamics and conducting gender-specific dissection of catecholamine dynamics have significant potential to advance personalized management of cardiac diseases management.
Marketing in the Era of Data Change

If we do not carry out the construction of modern system and without the help of informatization, it will not only waste time, but also be prone to errors. Using information technology, we can achieve three scientific and modern requirements. One is scientific process. Through information technology, all links of sorting, sorting, and receiving, distribution and transportation packaging are implemented in place, and automatic scanning instrument is used to ensure that the products are free from pollution, odor and wrong taking, and the one-stop process service is realized. The second is scientific operation, through information technology to integrate the collaborative supply chain, constantly analyze and improve their own problems, learn from each other to realize integrated supply, real-time information sharing, and promote all aspects of logistics into a higher level. Similarly, in this process, enterprises are no longer simply playing the role of logistics, but also should be introduced into modern science and technology industry, establish research bases within logistics, introduce information facilities, and contribute to the promotion of corporate culture.
Designing Migraine Applications

Migraine is ranked as the third most widespread disease in the world by Global burden of Disease and study 2010. To reduce pressure on health care and also help patients understand their condition, mobile health applications have become increasingly popular and accessible. These applications help by providing disease information, to document symptoms and analyze attack patterns. However, there is both a lack of patient centered perspective and scientific based knowledge behind the design of these applications. Therefore, the aim of this study is to explore what might affect the patients’ motivation to use a mobile application to explore their condition. This by looking into how these applications can be designed so that patients’ find them helpful and easy to use. This was done by doing a qualitative interview study with ten patients with severe migraine and analyzing the transcribed data through a reflexive thematic analysis. The thematic analysis resulted in three overarching themes personal motivations of exploring migraine , health care related motivations of exploring migraine , and technical support for motivation of exploring migraine . Each overarching theme contained themes and sub-themes that are backed up by quotes in the data from the interviews. Also a proposal on how to visualize the three overarching themes in relation to each other is presented.
Exonic copy number variations in rare genetic disorders

Exonic copy number variation (CNV), involving deletions and duplications at the gene’s exon level, presents challenges in detection due to their variable impact on gene function. The study delves into the complexities of identifying large CNVs and investigates less familiar but recurrent exonic CNVs, notably enriched in East Asian populations. Examining specific cases like DRC1, STX16, LAMA2, and CFTR highlights the clinical implications and prevalence of exonic CNVs in diverse populations. The review addresses diagnostic challenges, particularly for single exon alterations, advocating for a strategic, multi-method approach. Diagnostic methods, including multiplex ligation-dependent probe amplification, droplet digital PCR, and CNV screening using next-generation sequencing data, are discussed, with whole genome sequencing emerging as a powerful tool. The study underscores the crucial role of ethnic considerations in understanding specific CNV prevalence and ongoing efforts to unravel subtle variations. The ultimate goal is to advance rare disease diagnosis and treatment through ethnically-specific therapeutic interventions.
THE RELATIONSHIP BETWEEN DIGITAL GAME ADDICTION, EXECUTIVE FUNCTIONS AND IMPULSIVITY IN EARLY ADOLESCENTS

Privacy is what one can be in his or her private space without being disturbed by others. Privacy invasion is the unauthorized intervention of other people in the private area of the person. The current study was largely concerned with the association between digital game addiction, specific cognitive functions especially, three components of executive function (inhibition, set shifting and working memory) and impulsivity in early adolescents. Sampling consisted of 6th (55.1%) and 7th (44.9%) grade middle school students (36 females and 62 males). The mean age of the students was determined as 12.35 years (SD =0.75; age range, 10–14 years). Digital game addiction, inhibition, set shifting, working memory, and impulsivity were evaluated via Digital Game Addiction Scale (DGAS), Stroop Test TBAG Form, Trail Making Test (TMT), Wechsler Memory Scale-III Letter-Number Sequencing Subtest (WMS–III/LNS) and Short Form of Barratt Impulsiveness Scale (BIS-11-SF), respectively. According to the correlation analysis results, selective and complex attention, inhibition, set shifting, and impulse control were diminished with increasing digital game addiction. There is no significant relationship between digital game addiction and working memory. Consistent with the correlation analysis, structural equation model results revealed that digital game addiction significantly predicts inhibition, set shifting and impulsivity [x2 (15, N = 98) = 7.476, p > 0.5; x2/df = 1.246; RMSEA = . 05; CFI = . 95; GFI = . 97]. As a results, it can be concluded that digital game addiction should be controlled in order to manage impulses and develop high-capacity cognitive skills in children.
Novel homozygous mutations in TXNDC15 causing Meckel syndrome

Abstract Background Meckel syndrome (MKS) is the most severe form of an autosomal recessive ciliopathy and is clinically characterized by occipital encephalocele, severely polycystic kidneys, and postaxial polydactyly (toes). The association of TXNDC15‐related MKS has been reported. We report the case of a homozygous mutation in the TXNDC15 gene, causing MKS14 in the Chinese population. Methods The fetal skin tissue and parental peripheral blood were retained for whole‐exome sequencing and Sanger sequencing, which investigated the potential pathogenic variants associated with MKS. Results The fetus was homozygous for a mutation in the TXNDC15 gene (NM_024715.3), specifically c.560delA (p.Asn187llefsTer4), and both parents were heterozygous for this mutation. Conclusion Our study identified a new mutation that adds to the mutational landscape of MKS, which provide a basis for genetic counseling and the selection of reproductive options.
Potential For Conversion Of Rice Fields For Farmers In Pendoworejo District, Kap. Girimulyo, Kab. Kulon Progo, Special Region of Yogyakarta

Pendoworejo Village, Kapanewon Girimulyo, Kab. Kulon Progo, DIY is an area designated by the government as LP2B (Sustainable Food Agricultural Land), but in reality, this area is experiencing quite a drastic shrinkage of agricultural land. This is influenced by the existing Trend “culinary with view” in the Kulon Progo area which is directly proportional to the widespread conversion of agricultural land into culinary business buildings. This phenomenon is a consequence of the modernization process in developing regions. This research aims to discover the social and economic impacts of local farmers in Pendoworejo District. To find answers to these problems, researchers used qualitative phenomenological research methods. The data obtained is primary data from interviews with informants who are farmers in Pendoworejo Village. This research shows that agricultural land conversion has the potential to have a social impact on local farmers in the form of reduced urbanization rates, changes in people's mindsets, cultural shock, and increasing affordability and availability of employment sectors. Meanwhile, the economic impact of agricultural land conversion is reducing unemployment, establishing relationships between entrepreneurs and the community, and increasing household income in local communities.
Method for evaluating free surface and n.c. system

The system assumes the free surface and any point in space. The distance vector is defined such that the vector is directed to any point on the free surface on a surface at right angles or normal to the free surface and such that the distance between them is a minimum. The normal vector is formed on the free surface according to the distance vector using a surface interpolation expression for the free surface. The polarity of an internal product of the distance vector and the normal vector is determined and used to distinguish the domains or regions of the free surface.
Infrared heat map defect target detection based on Yolov5

At present, the object detection algorithm based on deep learning has gradually replaced the traditional object detection algorithm and become the main research algorithm in object detection and other tasks. For target detection under infrared conditions, the characteristics of infrared heat map will affect the ability of target detection and extraction, resulting in the impact of detection accuracy and speed. In order to solve the problem of low detection accuracy of YOLOv5 in industrial infrared scenes, this paper improved its network model structure, added NAM attention mechanism, and improved the feature pyramid network in the model. In this paper, all experimental results are summarized: the improved YOLOv5 network model not only has better detection accuracy but also improves detection speed, which can better meet the requirements of infrared heat map defect target detection.
Nest box occupancy dynamics by hazel dormice (Muscardinus avellanarius) in central-western Romania

The hazel dormouse, Muscardinus avellanarius is a vulnerable and protected species that is challenging to study due to its specific way of life. Limited data on its distribution and population parameters are available for Romania. We collected data regarding species’ biology and ecology in the hilly areas of central-western Romania, within deciduous forests dominated by oak or beech species. We regularly monitored 80 wooden nestboxes, which served as shelter and breeding sites for the species, to assess the seasonal and sex-related variations in nest box usage. The highest occupancy levels were observed during the autumn, with a smaller peak in the spring. Males occupied more nest boxes than females, although the difference was not statistically significant. They also travelled greater distances. Most nest boxes were occupied by a single individual at a time. Recapture rates did not differ significantly between males and females, and most individuals were recaptured only once. Hazel dormice showed a high level of site fidelity, often returning to the same nestbox or one nearby. Interestingly, 14% of the females bred twice a year, which is a lower percentage compared to findings from other studies. Nest box occupancy rates in this region were also lower than those reported in other areas. However, it is important to note that these variations may be attributed to differences in methodology. The occupancy rate declined with the increased presence of the larger species, the fat dormouse Glis glis, which outcompeted the hazel dormouse.
Molecular and Functional Key Features and Oncogenic Drivers in Thymic Carcinomas

Simple Summary Thymic carcinomas are the most aggressive thymic epithelial tumors. While thymic carcinomas do not have a single specific cause, various aspects of their growth have been evaluated at the molecular level. In this review, we organize the recent findings according to what have been defined as the hallmarks of cancer. The identification of the molecular alterations that drive the growth of these tumors is crucial for the development of effective target therapies. Inactivation of CDKN2A, TP53, and CDKN2B by somatic mutation or deletion is most common in thymic carcinomas. In advanced tumors, mutations in genes that regulate epigenetic and chromatin remodeling can occur. On the contrary, mutations in tyrosine kinase receptors and other oncogenes are only occasional, with those of KIT being the most common and present in only 10% of thymic carcinomas. Thymic carcinomas present an enhanced and aberrant vasculature that has been targeted in clinical trials with promising results. Additionally, thymic carcinomas evade the control of the immune system, with some tumors showing a response to immune checkpoint inhibitors. Abstract Thymic epithelial tumors, comprising thymic carcinomas and thymomas, are rare neoplasms. They differ in histology, prognosis, and association with autoimmune diseases such as myasthenia gravis. Thymomas, but not thymic carcinomas, often harbor GTF2I mutations. Mutations of CDKN2A, TP53, and CDKN2B are the most common thymic carcinomas. The acquisition of mutations in genes that control chromatin modifications and epigenetic regulation occurs in the advanced stages of thymic carcinomas. Anti-angiogenic drugs and immune checkpoint inhibitors targeting the PD-1/PD-L1 axis have shown promising results for the treatment of unresectable tumors. Since thymic carcinomas are frankly aggressive tumors, this report presents insights into their oncogenic drivers, categorized under the established hallmarks of cancer.