Miracle-dz/UniFAR-FTUs huggingface dataset:
Not Tonight Dear, I'm Deconstructing a Headache

Abstract The meanings attributed to sexual encounters are notoriously fluid. At the beginning of the twentieth century, eroticized contact between two women was widely regarded as evidence of moral and physical degeneracy-even by those women engaging in such contact. By the end of the century, a significant proportion of self-identified lesbians had come to regard same-sex erotic contact as a healthy expression of love. In fact, the meanings ascribed to same-sex erotic contact had changed so dramatically that, by 1979, the absence of such contact in lesbian relationships was considered un-healthy-a condition for which couples often sought “treatment. ” In this article, the author, a longtime San Francisco Bay Area lesbian sex therapist, chronicles the evolution of these treatments and reflects upon the twenty-five years she spent adapting and administering them.
An Exploration of the Structure of Effective Apologies

Violations of trust are an unfortunate but common occurrence in conflict and negotiation settings: negotiators make promises that they do not keep; parties in conflict behave in unexpected ways, escalating tensions and breaking past trust. What often follows these violations is some form of an account, specifically an apology, in an effort to repair that trust. But are some apologies more effective than others? Two studies reported here examine the structural components of apologies. Six components of an apology were defined from previous research and presented to subjects—singly and in combination—in the form of component definitions and in the context of a trust violation scenario. Results indicate that not all apologies are viewed equally; apologies with more components were more effective than those with fewer components, and certain components were deemed more important than others. Moreover, apologies following competence-based trust violations were seen as more effective than apologies following integrity-based violations. Implications and future directions for research in the structure of effective apologies are presented.
Peroxisome proliferator-activated receptor-c interrupts angiogenic signal transduction by transrepression of platelet-derived growth factor-b receptor in hepatic stellate cells

Hepatic stellate cells (HSCs) are liver-specific pericytes that are recruited to vessels and secret pro-angiogenic cytokines, and thus actively involved in pathological vascularization during liver fibrosis. Peroxisome proliferator-activated receptor-c (PPARc) is a switch molecule controlling HSC activation. We investigated PPARc regulation of angiogenic signal transduction and the molecular mechanisms involved in HSCs. Primary rat HSCs and liver sinusoidal endothelial cells (LSECs) were isolated and used in this study. Boyden chamber and tubulogenesis assays, identified that focal adhesion kinase (FAK)–RhoA signaling activated by platelet-derived growth factor (PDGF) was required for HSC motility and the associated vascularization. PDGF also stimulated vascular endothelial growth factor (VEGF) expression and HSC-driven vascularization through signals mediated by extracellular signalregulated kinase (ERK) and mammalian target of rapamycin (mTOR). Gainand loss-of-function analyses demonstrated that activation of PPARc interrupted FAK–RhoA, ERK and mTOR cascades and inhibited HSC-based vascularization. Molecular evidence further revealed that PPARc attenuation of HSC angiogenic properties was dependent on inhibition of PDGF-b receptor expression. We concluded that PPARc inhibited angiogenic signal transduction through transrepression of PDGF-b receptor leading to reduced HSC motility, reduced VEGF expression, and thereby attenuated HSC-driven angiogenesis. PPARc could be a molecular target for preventing vascular remolding in hepatic fibrosis.
DIVERGENCE IN MORPHOLOGY AND MATING SIGNALS, AND ASSORTATIVE MATING AMONG POPULATIONS OF CHORTHIPPUS PARALLELUS (ORTHOPTERA: ACRIDIDAE)

Three geographically widely separated populations of the grasshopper Chorthippus parallelus (Orthoptera: Acrididae) have been examined for morphological divergence, divergence in characteristics of the acoustic sexual signals of males, and assortative mating. Significant assortative mating existed between two of the three pairwise combinations of populations in multiple‐choice tests. This may be caused by divergence in three of the four acoustic signal parameters measured. The populations also differed in morphology, including characters associated with signal production. The results are discussed in relation to theories for the origin of premating isolation, and it is argued that the observed divergence has developed rapidly, possibly indicating the action of selection. However, this selection could not have been caused by interactions with closely related taxa.
Flexible echolocation behavior of trawling bats during approach of continuous or transient prey cues

Trawling bats use echolocation not only to detect and classify acoustically continuous cues originated from insects at and above water surfaces, but also to detect small water-dwelling prey items breaking the water surface for a very short time, producing only transient cues to be perceived acoustically. Generally, bats need to adjust their echolocation behavior to the specific task on hand, and because of the diversity of prey cues they use in hunting, trawling bats should be highly flexible in their echolocation behavior. We studied the adaptations in the behavior of Noctilio leporinus when approaching either a continuous cue or a transient cue that disappeared during the approach of the bat. Normally the bats reacted by dipping their feet in the water at the cue location. We found that the bats typically started to adapt their calling behavior at approximately 410 ms before prey contact in continuous cue trials, but were also able to adapt their approach behavior to stimuli onsets as short as 177 ms before contact, within a minimum reaction time of 50.9 ms in response to transient cues. In both tasks the approach phase ended between 32 and 53 ms before prey contact. Call emission always continued after the end of the approach phase until around prey contact. In some failed capture attempts, call emission did not cease at all after prey contact. Probably bats used spatial memory to dip at the original location of the transient cue after its disappearance. The duration of the pointed dips was significantly longer in transient cue trials than in continuous cue trials. Our results suggest that trawling bats possess the ability to modify their generally rather stereotyped echolocation behavior during approaches within very short reaction times depending on the sensory information available.
Contributions socio-cognitives aux dynamiques de coopération inter-organisationnelle autour de l'information géographique.

Le deploiement des Systemes d'Information Geographiques dans les collectivites, les administrations ou les entreprises se revele etre un veritable catalyseur de l'ouverture inter-organisationnelle. Ainsi, la creation de partenariats autour de l'information geographique est en forte croissance depuis plusieurs annees. Initiees generalement pour acquerir a frais partages des referentiels cartographiques, les dynamiques partenariales tentent de diversifier leurs champs d'action : elles s'interessent desormais a la mise en place de plate-forme d'echange voire de coproduction des donnees geographiques thematiques (ou metier). Au-dela des Infrastructures de Donnees Spatiales, ces initiatives tendent donc a favoriser l'emergence de Communautes de Pratique. Or, l'appropriation des donnees geographiques metier est influencee par les modeles cognitifs des acteurs. Ainsi, face a la multiplication des dynamiques de partage de donnees geographiques mais aussi, face a la multiplication des representations hyper-specialisees des experts, plusieurs questions restent en suspens : * Le partage de donnees geographiques thematiques peut-il se transformer en partage de connaissances sur le territoire ? * Comment l'acquisition de connaissances nouvelles sur le territoire peut provenir de l'intelligence metier de donnees issues d'un processus de partage inter-organisationnel ? * Plus concretement, comment un acteur peut s'approprier une donnee thematique qu'il n'a pas produite ? Repondre a ces interrogations nous permettra alors de tenter de repondre a la problematique plus generale du role de la donnee geographique dans la cooperation entre les acteurs du territoire. Pour ce faire, l'expose se propose de presenter un modele d'appropriation des donnees geographiques metier dans un contexte multi-acteurs. Ce dernier a ete etabli a partir d'un cadre theorique qui s'appuie sur une perspective socio-cognitive. Nous l'avons confronte a une dizaine d'etudes de cas qui seront succinctement presentees. Enfin, nous terminerons cette presentation par une conclusion sur la contribution des theories socio-cognitives au design organisationnel et technologique des dynamiques de cooperation inter-organisationnelle autour de l'information geographique.
Ligand-induced protease receptor translocation into caveolae: a mechanism for regulating cell surface proteolysis of the tissue factor- dependent coagulation pathway

The ability to regulate proteolytic functions is critical to cell biology. We describe events that regulate the initiation of the coagulation cascade on endothelial cell surfaces. The transmembrane protease receptor tissue factor (TF) triggers coagulation by forming an enzymatic complex with the serine protease factor VIIa (VIIa) that activates substrate factor X to the protease factor Xa (Xa). Feedback inhibition of the TF-VIIa enzymatic complex is achieved by the formation of a quaternary complex of TF-VIIa, Xa, and the Kunitz-type inhibitor tissue factor pathway inhibitor (TFPI). Concomitant with the downregulation of TF-VIIa function on endothelial cells, we demonstrate by immunogold EM that TF redistributes to caveolae. Consistently, TF translocates from the Triton X-100-soluble membrane fractions to low- density, detergent-insoluble microdomains that inefficiently support TF- VIIa proteolytic function. Downregulation of TF-VIIa function is dependent on quaternary complex formation with TFPI that is detected predominantly in detergent-insoluble microdomains. Partitioning of TFPI into low-density fractions results from the association of the inhibitor with glycosyl phosphatidylinositol anchored binding sites on external membranes. Free Xa is not efficiently bound by cell-associated TFPI; hence, we propose that the transient ternary complex of TF-VIIa with Xa supports translocation and assembly with TFPI in glycosphingolipid-rich microdomains. The redistribution of TF provides evidence for an assembly-dependent translocation of the inhibited TF initiation complex into caveolae, thus implicating caveolae in the regulation of cell surface proteolytic activity.
Universal scaling rules predict evolutionary patterns of myogenesis in species with indeterminate growth

Intraspecific phenotypic variation is ubiquitous and often associated with resource exploitation in emerging habitats. For example, reduced body size has evolved repeatedly in Arctic charr (Salvelinus alpinus L.) and threespine stickleback (Gasterosteus aculeatus L.) across post-glacial habitats of the Northern Hemisphere. Exploiting these models, we examined how body size and myogenesis evolve with respect to the ‘optimum fibre size hypothesis’, which predicts that selection acts to minimize energetic costs associated with ionic homeostasis by optimizing muscle fibre production during development. In eight dwarf Icelandic Arctic charr populations, the ultimate production of fast-twitch muscle fibres (FNmax) was only 39.5 and 15.5 per cent of that in large-bodied natural and aquaculture populations, respectively. Consequently, average fibre diameter (FD) scaled with a mass exponent of 0.19, paralleling the relaxation of diffusional constraints associated with mass-specific metabolic rate scaling. Similar reductions in FNmax were observed for stickleback, including a small-bodied Alaskan population derived from a larger-bodied oceanic stock over a decadal timescale. The results suggest that in species showing indeterminate growth, body size evolution is accompanied by strong selection for fibre size optimization, theoretically allowing resources saved from ionic homeostasis to be allocated to other traits affecting fitness, including reproduction. Gene flow between small- and large-bodied populations residing in sympatry may counteract the evolution of this trait.
A Project-Based Cooperative Approach to Teaching Sustainable Energy Systems

Engineering education is undergoing a restructuring driven by the needs of an increasingly multidisciplinary engineering profession. At the same time, power systems are transitioning toward future smart grids that will require power engineers with skills outside of the core power engineering domain. Since including new topics in the existing curriculum while maintaining the existing requirements is difficult, this paper proposes a project-based cooperative learning approach to promote soft skills in an engineering course. This paper then shows how to construct a realistic open-ended multidisciplinary problem whose solution requires a wide range of skills, which is not a trivial task. The design and technoeconomic viability assessment of a small-scale photovoltaic battery system is used as a case study. The effectiveness of the approach and students’ satisfaction were assessed over two years. Survey results after the first year revealed that the students did not feel sufficiently prepared for multidisciplinary work. After appropriate adjustments in the second year, the survey results improved noticeably. Statistical analysis reveals that the project teaches skills that are complementary to the core domain skills, which confirms the validity of the approach.
Pinopodes: a questionable role in endometrial receptivity.

BACKGROUND A better understanding of endometrial receptivity is crucial to the creation and optimization of tests to assess the window of implantation in a clinical setting. Testing endometrial receptivity via scanning electron microscopy of endometrial samples reveals that pinopodes are a very good marker of endometrial receptivity in the rat. There is still disagreement in the literature as to their usefulness as a receptivity marker in both mice and humans. METHODS Publications related to the discovery, study and usefulness of pinopodes as a marker of endometrial preparation for implantation in both rodents and humans were identified through MEDLINE and other bibliographic databases. RESULTS There is substantial evidence that pinopodes are good markers of endometrial receptivity in the rat. Pinopodes are not useful in the mouse or human as consistent markers of endometrial receptivity for implantation. In the human, pinopodes have a prolonged (>5 days) presence in the luteal phase and fail to delineate the brief (24-48 h) window of receptivity. CONCLUSIONS While there are many publications arising from one group supporting the use of pinopodes as a reliable marker of human endometrial receptivity, few independent groups have been able to confirm these results. The clinical usefulness of pinopodes to delineate a period of endometrial receptivity seems unlikely following recent findings that pinopodes are present throughout the luteal phase of the menstrual cycle.
The Quality of Primary Care Experienced by Health Center Patients

Background: We investigated the quality of the primary care experienced by health center (HC) patients and investigated whether race/ethnicity and insurance coverage were significantly associated with patients' experiences. Methods: Cross-sectional data came from the 2009 Health Center Patient Survey. Outcomes included 10 measures of patients' experiences with primary care domains, including: (1) accessibility, (2) communication, (3) comprehensiveness, and (4) coordination of care. Results: Patients who received care at HCs reported high-quality primary care, particularly regarding accessibility and communication. For example, more than 94% of patients reported that their HC location was convenient, and more than 94% reported that their provider adequately explained what they wanted to know. After adjusting for sociodemographic characteristics, few significant racial/ethnic and insurance-related disparities were observed. In the domains of comprehensiveness and coordination, insured patients generally had better experiences than uninsured patients. For instance, Medicaid-insured patients had higher odds of reporting that HC staff helped them arrange medical appointments at other health care settings than uninsured patients (odds ratio, 2.04; 95% confidence interval, 1.35–3.09). Conclusions: As safety-net providers for vulnerable populations, HCs provide high-quality primary care and do not exhibit the extent of disparities that exist in other US health care settings. Continued efforts are necessary to address insurance-related disparities, particularly among uninsured patients.
Broadband millimetre-wave passive spatial combiner based on coaxial waveguide

A broadband millimetre-wave passive spatial combiner using a microstrip probe array and an oversized coaxial waveguide is successfully designed and tested. The equivalent circuit approach of transverse electromagnetic (TEM) lines is adopted to synthesise the coaxial stepped impedance transformer from a K connector with the oversized coaxial waveguide and to analyse the microstrip probe array. The equivalent susceptances of the step discontinuities for the power divider are calculated. A four-way coaxial waveguide passive power combining circuit operating at the entire Ka-band is designed, fabricated and measured. Experiments on the four-way passive combiner show that a minimum insertion loss of 0.7 dB has been achieved at about 29.5 GHz. The combiner has shown a bandwidth of 26.5-40 GHz with 10 dB return loss and less than 2.5 dB insertion loss.
The Size-Change Termination Principle for Constructor Based Languages

This paper describes an automatic termination checker for a generic first-order call-by-value language in ML style. We use the fact that value are built from variants and tuples to keep some information about how arguments of recursive call evolve during evaluation. The result is a criterion for termination extending the size-change termination principle of Lee, Jones and Ben-Amram that can detect size changes inside subvalues of arguments. Moreover the corresponding algorithm is easy to implement, making it a good candidate for experimentation.
Bilateral idiopathic sensorineural hearing loss following dental surgery.

BACKGROUND This is a case study of an 18-year-old female who suffered a bilateral idiopathic sensorineural hearing loss that was coincident with the removal of four impacted wisdom teeth, Throughout childhood the patient had normal hearing for pure tones bilaterally as measured at the pediatrician's office. One month prior to dental surgery (May) the patient volunteered to participate in an auditory experiment at which time her pure-tone audiogram was normal. Immediately following surgery (June), the patient had substantial swelling of the face and complained of some hearing loss with no other auditory/vestibular complaints. The following month (July) during the course of a routine physical examination a pure-tone audiogram revealed bilateral, air-conduction thresholds of 30-35 dB HL (500-4000 Hz) and 20 dB HL (8000 Hz). Because bone conduction was not tested, it is impossible to know whether the hearing loss was conductive, mixed, or sensorineural. The pediatrician thought that the hearing loss was conductive and would resolve as the edema subsided, A month later (August) the subject again volunteered for an auditory experiment at which time her hearing again was tested. PURPOSE The purpose of this report is to detail the dental procedures involved in the extraction of the wisdom teeth, to report the results of a variety and series of post-op hearing tests, and to discuss the possible mechanisms that might be involved in the "idiopathic" bilateral sensorineural hearing loss. RESEARCH DESIGN Case report. RESULTS During the August visit to the laboratory, hearing for pure tones bilaterally was 0 to 5 dB HL at 250-1000 Hz with a 40-45 dB HL notch at 2000 Hz with a return to 10 dB HL at 8000 Hz. Air conduction and bone conduction thresholds were equivalent. Word recognition in quiet was -92 percent correct for both ears, whereas the signal-to-noise ratio (SNR) hearing loss measured with the Words-in-Noise test was high normal in the left ear with a mild SNR hearing loss in the right ear. Tympanometry and acoustic reflex thresholds were normal. Distortion product otoacoustic emissions were reduced in the 1000-3000 Hz region for both ears, which is consistent with cochlear hearing loss. The hearing loss has remained unchanged for the past 19 months. CONCLUSIONS The possible etiologies, including insults to the cochleae by vibration trauma and through alterations in the blood supply to the cochleae, are considered.
Language Technologies for Suicide Prevention in Social Media

At present, the suicide phenomenon is raising, having a relevant impact on our society. Each year about one million people die as a result of suicidal behavior becoming an economic, social and human problem. On the other hand, the use of Social Media as a means of communication is becoming extremely popular, through which their emotional states and impressions are exchanged. Therefore, it is no surprise that more and more people with depression publish their suicide notes in these communication channels. In this context, Information Technologies and Communications and, more specifically, Language Technologies play an important role in the early detection of the depression, their causes and their terrible consequences. Based on these considerations, it is mandatory to provide societal, environmentally approaches and solutions to tackle these societal challenges. This work pretends to be an exhaustive survey of the different researches in this scope, in order to explain which methodologies, technologies and resources are used in the detection of mental problems by means of the Social Media analysis as well as to re-veal their deficiencies.
High resolution projection reconstruction MR imaging using FOCUSS

This paper is concerned about high resolution reconstruction of projection reconstruction MR imaging from angular under-sampled k-space data. A similar problem has been recently addressed in the framework of compressed sensing theory. Unlike the existing algorithms used in compressed sensing theory, this paper employs the FOCal Underdetermined System Solver(FOCUSS), which was originally designed for EEG and MEG source localization to obtain sparse solution by successively solving quadratic optimization. We show that FOCUSS is very effective for the projection reconstruction MRI, because the medical images are usually sparse in image domain, and the center region of the under-sampled radial k-space data still provides a meaningful low resolution image, which is essential for the convergence of FOCUSS. We applied FOCUSS for projection reconstruction MR imaging using single coil. Extensive experiments confirms that high resolution reconstruction with virtually free of angular aliasing artifacts can be obtained from severely under-sampled k-space data.