Miracle-dz/UniFAR-FTUs huggingface dataset:
Counting Cells in Sectioned Material: A Suite of Techniques, Tools, and Tips

This unit presents protocols to obtain accurate estimates of cell density and cell number in sectioned material by using a light microscope. The “optical disector” or “3‐D counting method” is described, followed by Abercrombie's less commonly used two‐section comparison (TSC) method. These basic protocols are accompanied by four support protocols: one for celloidin embedding, which renders superb morphology, one for point counting, which is important for volume measurements and is almost always used in conjunction with the disector or 3‐D counting, one for handling the potential problem of z‐axis distortion and the consequences that this error can have on density estimates and sampling tactics when using the disector, and finally, one that provides a guide for calibrating and verifying estimates obtained by counting methods.
Does the Timing of Silicone Tube Removal Following External Dacryocystorhinostomy Affect Patients' Symptoms?

Aims: To investigate whether the timing of silicone tube removal after external dacryocystorhinostomy (EXT-DCR) for lacrimal outflow obstruction affects outcome. Methods: Retrospective chart review and follow-up by telephone survey of 205 consecutive patients undergoing EXT- DCR. Long-term success was evaluated by telephone survey. Results: Full data was collected in 180 out of 205 DCRs. Ninety four tubes (52.3%) were removed routinely between 2 and 4 months after surgery, 24 tubes (13.3%) were removed before the planned 2-month period and 62 tubes (34.4%) were removed after the planned 4-month period. The three groups (early, routine and late) were comparable in terms of age, gender distribution, mode of anaesthesia, proportion of repeat EXT-DCRs and seniority of surgeon. The mean follow-up period was 3 years and 10 months. One hundred and twenty-eight of the 155 patients (82.5%) were contactable by phone. In the routine tube removal group, at the time of follow-up, 65.1% experienced complete symptom resolution, 25.4% experienced partial symptom resolution, 6.3% experienced no symptom resolution and 3.2% experienced worse symptoms. In the early tube removal group, at the time of follow-up, 63% experienced complete symptom resolution, 32% experienced partial symptom resolution and 5% experienced no change in symptoms. In the late tube removal group, at the time of follow-up, 70% experienced complete symptom resolution, 21.5% experienced partial symptom resolution and 8.5% experienced no symptom resolution. There was no statistically significant difference in the outcome of the three groups. Conclusions: Our experience and this study suggest that timing of silicone tube removal does not influence surgical success in EXT-DCR regardless of the cause of early or late tube removal.
Evaluating the Effectiveness of Team-Based Learning in Undergraduate Criminal Justice Courses

Team-based learning (TBL), as developed by Larry Michaelsen, is a pedagogical strategy designed to incorporate group processes in academic settings. The effectiveness of TBL as a teaching method has been tested in a number of disciplines with mixed results. Few empirical tests of TBL in the undergraduate criminal justice classroom exist. Articles concerning TBL in the criminal justice classroom are predominantly descriptive and expository in nature, leaving questions about potential effectiveness of this teaching method in the discipline. This study evaluates the effectiveness of TBL in comparison with a lecture-based course. Results indicate that students in the TBL course reported higher levels of student involvement, preparation, and accountability. However, there were no statistically significant differences in overall student performance in comparison with those in the lecture-based course. The article reviews the potential benefits and drawbacks of using TBL.
Realization of dynamic behavior using remotely verifiable n-call slides in Unix process execution trace

Trusted computing presents a technique called remote attestation which helps in verifying the trustworthiness of a client's system. Generally known and mostly used methods to verify a target system's integrity are mostly static in nature. For the purpose of mitigating this problem many approaches have been presented. However, none of these are feasible either because of implementation complexity or because of an unrealistically high bandwidth requirement. In this paper, we propose STIDE-R, an approach that utilizes the concepts of the seminal work presented by STIDE -- a technique that measures the behavior of an application based on the sequence of system calls made. We focus on how to shorten the length of data that needs to be reported to the challenger. The principle advantage achieved is detection of zero-day malware at a remote system without incurring infeasible performance overhead. Further, the proposed architecture considers two dimensions as the most important for successful implementation of dynamic behavior attestation. These are to minimize the processing time on the target remote platform and to tackle the network overhead efficiently.
Supporting multiple subscription languages by a single event notification overlay in sparse MANETs

The subscription language is an important design decision for distributed event notification services (DENS). In order to minimize resource consumption and enable applications to use rich and complex subscription languages only when they are really needed, we have developed a DENS that separates the concerns of delivering subscriptions and notifications from the subscription specification and event filtering, i.e., the subscription language. To resolve the conflict between subscription language independence in DENS and a strict decoupling of publishers and subscribers through the DENS, we request that for each new subscription language three language specific plug-ins are provided. In this paper, we present the technical details of this solution and describe our proof-of-concept implementation that supports a simple attribute-value based subscription language and a fuzzy concept-based language.
Treatment with IL-7 Prevents the Decline of Circulating CD4+ T Cells during the Acute Phase of SIV Infection in Rhesus Macaques

Although treatment with interleukin-7 (IL-7) was shown to transiently expand the naïve and memory T-cell pools in patients with chronic HIV-1 infection receiving antiretroviral therapy (ART), it is uncertain whether a full immunologic reconstitution can be achieved. Moreover, the effects of IL-7 have never been evaluated during acute HIV-1 (or SIV) infection, a critical phase of the disease in which the most dramatic depletion of CD4+ T cells is believed to occur. In the present study, recombinant, fully glycosylated simian IL-7 (50 µg/kg, s.c., once weekly for 7 weeks) was administered to 6 rhesus macaques throughout the acute phase of infection with a pathogenic SIV strain (mac251); 6 animals were infected at the same time and served as untreated controls. Treatment with IL-7 did not cause clinically detectable side effects and, despite the absence of concomitant ART, did not induce significant increases in the levels of SIV replication except at the earliest time point tested (day 4 post-infection). Strikingly, animals treated with IL-7 were protected from the dramatic decline of circulating naïve and memory CD4+ T cells that occurred in untreated animals. Treatment with IL-7 induced only transient T-cell proliferation, but it was associated with sustained increase in the expression of the anti-apoptotic protein Bcl-2 on both CD4+ and CD8+ T cells, persistent expansion of all circulating CD8+ T-cell subsets, and development of earlier and stronger SIV Tat-specific T-cell responses. However, the beneficial effects of IL-7 were not sustained after treatment interruption. These data demonstrate that IL-7 administration is effective in protecting the CD4+ T-cell pool during the acute phase of SIV infection in macaques, providing a rationale for the clinical evaluation of this cytokine in patients with acute HIV-1 infection.
Interaction between postural risk factors and job strain on self-reported musculoskeletal symptoms among users of video display units: a three-year prospective study.

OBJECTIVE This study investigated a possible interaction between postural risk factors and job strain on the incidence proportion of self-reported musculoskeletal symptoms in the shoulder-neck, lower back and upper limbs regions. METHODS A cohort of white-collar workers (N=2431) was assessed with a self-administered questionnaire regarding postural risk factors and job strain at work. After a three-year follow-up, the six-month incidence proportion of musculoskeletal symptoms in the three body regions was measured with a modified version of the Nordic questionnaire. The analyses were stratified for gender. Interaction was defined as a departure from the addition of effects of individual risk factors, and its importance was estimated from the attributable proportion due to interaction and its 95% confidence interval (95% CI). RESULTS A significant attributable proportion of 0.80 (95% CI 0.23-1.37) due to interaction between postural risk factors and job strain was observed for men in the lower back region. An indication of interaction was found for women with attributable proportions due to interaction of 0.44 (95% CI -0.06-0.94), 0.27 (95% CI -0.34-0.88) and 0.36 (95% CI -0.33-1.05) for the shoulder-neck, lower back, and upper limbs regions, respectively. CONCLUSIONS The simultaneous presence of postural risk factors and job strain seems to increase the pathogenic effect of each exposure on the incidence proportion of musculoskeletal symptoms. This interaction effect is important for work intervention practices as success in decreasing any of these two risk factors could have the additional benefit of reducing up to 80% of new cases of musculoskeletal symptoms among participants exposed to both risk factors.
Processo de Compra e os Atributos de Loja Valorizados pelos Consumidores: Um Estudo Comparativo com Consumidores Paulistas

Due to the increasing competition and allied to the political, economical, social and technological uncertainness, the Brazilian retailer section has been through a transforming process conducted by the market pressure itself, and also by the constant pursuit of survival. In such scenario, one can detach the importance of glimpsing concerns related to the consistency among the store attributes valued by the consumers and those offered by the retailer, since such facts constitute relevant factors in the selection process and choice of the store. In this perspective, this paper aims at identifying the attributes that mark value in the cosmetics purchase process. To do so, it took place a research of survey type, starting with a non-probabilistic intentional sample of 400 respondents who live in the country side of Sao Paulo. The results obtained through the factorial analysis and the arithmetic average ( x ) for the generated factors evidenced the importance of the attribute price and promotion for both genders. They also showed that there are no significant differences between men and women regarding the most valued attributes in the cosmetics purchase process.
The Intersection of Economic Signals and Mythical Symbols

Mythical symbols and economic signals represent more than what they are. Symbols represent universal ideas and themes and evoke feelings and emotions, while economic signals are simple, efficient signs that stand for a more complex set of characteristics and information that are costly to learn. Symbols deal with the irrational and economic signals deal with the rational. Many of the signals cited in economic literature work well because they have a symbolic element that speaks to people's emotions. By evoking emotions, a signal makes the receiver feel more confident about the truthfulness of the information it represents. The intersection of symbols and signals illustrates the relationship between the rational world of facts and irrational world of emotions and values, a relationship which needs to be explored as part of the development of the ideal type of homo socio economicus, the selfish yet value and community-driven person.
Antecedent Work Engagement and Organizational Commitment to Increase the Outsourcing Employees Performance in Department of Cleanliness and Horticultural

The purpose of this research was to analyze and explain perceived organization support and perceived supervisor support on work engagement and organizational commitment of employees, to analyze and explain the influence of work engagement on organizational commitment and the performance of the employees, and to analyze and explain the influence of organizational commitment on the performance of employees worker in Department of Cleanliness and Horticultural Samarinda. The design of this research was explanatory research or explanation research. The type of this research was observational research with cross sectional study design. The method was used to collect the data in this research was survey method. The population of this research was the whole daily impermanent employees (PTTH) in Department of Cleanliness and Horticultural Samarinda which amounted to 1.453 people. In this research, the sample that was used was 20% of population in each part or 292 people. The technic was used to take the sample was simple random sampling technic. This research used Partial Least Square (PLS) approach to analyze the data. PLS was the similarity model of Structural Equation Modeling (SEM) with component or variant base.The results of this research could be concluded as follows: perceived organization support had an insignificant influence on Samarinda employees work engagement. Perceived organization support had an insignificant influence on organizational commitment of Samarinda employees. Perceived supervisor support had a significant influence on Samarinda employees work engagement. Perceived supervisor support had insignificant influence on organizational commitment of Samarinda employees. Work engagement had a significant influence on organizational commitment of Samarinda employees. Work engagement had a significant influenced on Samarinda employees performance. Organizational commitment had an insignificant influence on Samarinda employees performance. Keywords: Perceived organization support, perceived supervisor support, work engagement, organizational commitment, employees performance.
Les relations sociales dans les multinationales françaises industrielles à l’Est : transfert, hybridation ou laboratoire de nouvelles pratiques ?

L’article s’interroge sur la place et le role des politiques de gestion des ressources humaines comme facteur de differenciation des modeles de relations sociales locales, entre les sites de differents groupes francais et leurs filiales est-europeennes. Il s’appuie sur un travail d’enquete realise aupres de huit multinationales francaises appartenant a trois secteurs d’activite (automobile, energie, agroalimentaire) implantees dans trois nouveaux Etats membres (Hongrie, Slovaquie, Roumanie). La grille de lecture proposee pour decrypter ces politiques mobilise les notions d’hybridation et de compromis forgees par l’approche en termes de regulation et completees par le courant « micropolitique » qui insiste sur l’importance des rapports de pouvoir comme facteur de differenciation de ces politiques. Plusieurs resultats ressortent de l’enquete. Deux modeles-types de gestion fortement correles a la structure du capital (actionnarial/familial) et au mode de gouvernance (centralise/decentralise) sont mis en evidence. L’enquete souligne egalement l’importance du dialogue social comme outil de gestion au service de la strategie industrielle. Enfin, elle permet de degager, pour les differentes firmes et leurs territoires d’implantation, plusieurs variantes locales de relations sociales.
On Firing Rate Estimation for Dependent Interspike Intervals

Abstract If interspike intervals are dependent, the instantaneous firing rate does not catch important features of spike trains. In this case, the conditional instantaneous rate plays the role of the instantaneous firing rate for the case of samples of independent interspike intervals. If the conditional distribution of the interspikes intervals (ISIs) is unknown, it becomes difficult to evaluate the conditional firing rate. We propose a nonparametric estimator for the conditional instantaneous firing rate for Markov, stationary, and ergodic ISIs. An algorithm to check the reliability of the proposed estimator is introduced, and its consistency properties are proved. The method is applied to data obtained from a stochastic two-compartment model and to in vitro experimental data.
Handbook of sexual assault: Issues, theories, and treatment of the offender.

Introduction: Issues in Sexual Assault W.L. Marshall, et al. The Nature and Extent of Sexual Assault G.G. Abel, J.L. Rouleau. Classifying Sexual Offenders: The Development and Corroboration of Taxonomic Models R.A. Knight, R.A. Prentky. Factors Influencing Sexual Assault: Sexual Aggression: Achieving Power Through Humiliation J.L. Darke. The Influence of Pornography on Sexual Crimes M.R. Murrin, D.R. Laws. Androgenic Hormones and Sexual Assault S.J. Hucker, J. Bain. Sexual Anomalies and the Brain R. Langevin. Stimulus Control of Sexual Arousal: Its Role in Sexual Assault H.E. Barbaree. Social and Cultural Factors in Sexual Assault L.E. Stermac, et al. The Role of Cognition in Sexual Assault Z.V. Segal, L.E. Stermac. Theories of Sexual Assault: Sex Offenders: A Feminist Perspective J.L. Herman. Court Disorder K. Freund. Treatment of the Offender: The Modification of Sexual Preferences V.L. Quinsey, C.M. Earls. The Antiandrogen and Hormonal Treatment of Sex Offenders J.M. W. Bradford. 8 additional articles. Index.
Deriving hierarchically combined queueing Petri nets for performance prediction of distributed component system

In this paper we propose the performance analysis and improvement methodology based on Hierarchically Combined Queueing Petri Nets (HQPNs). To accomplish the goal, in this paper, we firstly propose architecture design and performance profiling methodology by using UML. Secondly, we propose transformation algorithm from the UML based software architecture into HQPNs model. Lastly we offers performance analysis tool to identify potential bottleneck and critical component from the derived HQPNs model. We validate the accuracy of performance prediction by applying real system development scenario. We compare the predicted performance results with the performance data of the real system. This approach reduces the time and the cost caused by developing the HQPNs model at the software architecture design phase.
Easy dye application at surveillance colonoscopy: modified use of a washing pump

Pan-colonic chromo-endoscopy appears to enhance the detection of subtle colonic lesions such as flat adenomas and dysplasia-associated lesions/masses (DALMs) in patients undergoing surveillance colonoscopy.1 Recent British Society of Gastroenterology guidelines now recommend pan-colonic dye spray during colonoscopy for ulcerative colitis surveillance.2 A practical drawback to the use of pan-colonic dye …
Activity of second-generation ALK inhibitors against crizotinib-resistant mutants in an NPM-ALK model compared to EML4-ALK

Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor involved in both solid and hematological tumors. About 80% of ALK‐positive anaplastic large‐cell lymphoma (ALCL) cases are characterized by the t(2;5)(p23;q35) translocation, encoding for the aberrant fusion protein nucleophosmin (NPM)‐ALK, whereas 5% of non‐small‐cell lung cancer (NSCLC) patients carry the inv(2)(p21;p23) rearrangement, encoding for the echinoderm microtubule‐associated protein‐like 4 (EML4)‐ALK fusion. The ALK/c‐MET/ROS inhibitor crizotinib successfully improved the treatment of ALK‐driven diseases. However, several cases of resistance appeared in NSCLC patients, and ALK amino acid substitutions were identified as a leading cause of resistance to crizotinib. Second‐generation ALK inhibitors have been developed in order to overcome crizotinib resistance. In this work, we profiled in vitro the activity of crizotinib, AP26113, ASP3026, alectinib, and ceritinib against six mutated forms of ALK associated with clinical resistance to crizotinib (C1156Y, L1196M, L1152R, G1202R, G1269A, and S1206Y) and provide a classification of mutants according to their level of sensitivity/resistance to the drugs. Since the biological activity of ALK mutations extends beyond the specific type of fusion, both NPM‐ALK‐ and EML4‐ALK‐positive cellular models were used. Our data revealed that most mutants may be targeted by using different inhibitors. One relevant exception is represented by the G1202R substitution, which was highly resistant to all drugs (>10‐fold increased IC50 compared to wild type) and may represent the most challenging mutation to overcome. These results provide a prediction of cross‐resistance of known crizotinib‐resistant mutations against all second‐generation tyrosine kinase inhibitors (TKIs) clinically available, and therefore could be a useful tool to help clinicians in the management of crizotinib‐resistance cases.
Can Community Colleges Afford to Improve Completion? Measuring the Cost and Efficiency Consequences of Reform

Community colleges are under pressure to improve completion rates and efficiency despite limited economic evidence on how to do so and the consequences of different reform strategies. Here, we set out an economic model of student course pathways linked to college expenditures and revenues. Using detailed data from a single college, we calculate baseline efficiency and differences in efficiency for students who follow different pathways. We simulate changes in output, expenditures, revenues, net revenues, and efficiency assuming that the college meets performance targets. We find substantial differences in efficiency across pathways and significant differences in efficiency across strategies to help students complete college. The model has wide practical application for community colleges.
Systemic Treatment of Breast Cancer Depending on BMI using L-Carnitine

According to the Ministry of Health in Ukraine 26% of the female population for 2015 was overweight or obese. Obesity a chronic metabolic character, which is the result of the interaction of the endogenous factors, environmental conditions and lifestyle. Endogenous factors could be considered a violation of the genetic and hormonal balance. The external conditions include irregular rhythm nutrition, use of substandard products. By disorders include sedentary lifestyle lifestyles.