Miracle-dz/UniFAR-FTUs huggingface dataset:
Career Adaptability, Self-Determination, and Life Satisfaction: A Mediational Analysis With People With Substance Use Disorder

Living a satisfying life is an important goal for people with substance use disorder (SUD). However, making decisions about the future, imagining future scenarios, and setting and attaining goals related to that future after treatment is a complex task. As several studies have shown, people with SUD experience multiple barriers to designing their future life at the individual, program, and social support levels. Using a life design approach, the aim of this study was to investigate the role career adaptability and self-determination play in life satisfaction for adults with SUD. More specifically, a partial mediation model focused on career adaptability and life satisfaction through enhanced self-determination was tested in a sample (n = 134) of people with SUD. Findings suggest that career adaptability is indirectly related to life satisfaction, mediated by self-determination. These results have important implications for practice in vocational rehabilitation and career counseling for people with SUD.
Effect of nitrogen fertilizer source on corn (Zea mays L.) optical sensor response index values in a rain-fed environment

ABSTRACT The use of optical sensors to detect nitrogen (N) deficiencies and determine in-season fertilizer recommendations has grown. Nitrogen responses are difficult to detect early in the growing season. The objective of this experiment was to determine if different N sources could deliver early season detection of N deficiencies. Four N fertilizer sources were applied at rates of 90 and 180 kg N ha−1 across three site-years. A Greenseeker and SPAD sensor were used to measure in-season fertilizer response index (RI). When differences in sensor RI values between N rates were present, they did not occur until the V9/10 growth stage. No specific N source provided superior results that led to a reliable, early season detection of N deficiency. Reliable differences in response index values could be detected beyond the V7/V8 growth stages. For earlier detection of N responsiveness, and potential N deficiency, other management strategies should be investigated.
Focus on TGF- b Signalling TGF- b superfamily expression and actions in the endometrium and placenta

Transforming growth factor b (TGF b ) superfamily members are closely associated with tissue remodelling events and reproductive processes. This review summarises the current state of knowledge regarding the expression and actions of TGF b superfamily members in the uterus, during the menstrual cycle and establishment of pregnancy. TGF b s and activin b subunits are abundantly expressed in the endometrium, where roles in preparation events for implantation have been delineated, particularly in promoting decidualisation of endometrial stroma. These growth factors are also expressed by epithelial glands and secreted into uterine ﬂuid, where interactions with preimplantation embryos are anticipated. Knockout models and embryo culture experiments implicate activins, TGF b s, nodal and bone morphogenetic proteins (BMPs) in promoting pre- and post-implantation embryo development. TGF b superfamily members may therefore be important in the maternal support of embryo development. Following implantation, invasion of the decidua by fetal trophoblasts is tightly modulated. Activin promotes, whilst TGF b and macrophage inhibitory cytokine-1 (MIC-1) inhibit, trophoblast migration in vitro, suggesting the relative balance of TGF b superfamily members participate in modulating the extent of decidual invasion. Activins and TGF b s have similar opposing actions in regulating placental hormone production. Inhibins and activins are produced by the placenta throughout pregnancy, and have explored as a potential markers in maternal serum for pregnancy and placental pathologies, including miscarriage, Down’s syndrome and pre-eclampsia. Finally, additional roles in immunomodulation at the materno-fetal interface, and in endometrial inﬂammatory events associated with menstruation and repair, are discussed. by the epithelial lining of the Fallopian tube and uterus. Whilst autocrine actions of activins and TGF b s on the uterus have been described during the preparation for implantation (such as the stimulationof pro-implantatory leukaemia inhibitor factor production), receptors for these factors are also expressed by embryos at varying stages of development. Indeed, in vitro studies have demonstrated that activin A and TGF b promote pre-implantation embryo development suggesting these factors are involved in maternal–foetal communication during the establishment of pregnancy. Continued functions can be extrapolated for these factors in post-implantation development from the spatial and temporal expression patterns of the ligands, receptors and binding proteins. TGF b secreted from the blastocyst has been proposed to induce apoptosis of endometrial epithelial cells during implantation.
Several components of global change alter nitrifying and denitrifying activities in an annual grassland

Summary 1The effects of global change on below-ground processes of the nitrogen (N) cycle have repercussions for plant communities, productivity and trace gas effluxes. However, the interacting effects of different components of global change on nitrification or denitrification have rarely been studied in situ. 2We measured responses of nitrifying enzyme activity (NEA) and denitrifying enzyme activity (DEA) to over 4 years of exposure to several components of global change and their interaction (increased atmospheric CO2 concentration, temperature, precipitation and N addition) at peak biomass period in an annual grassland ecosystem. In order to provide insight into the mechanisms controlling the response of NEA and DEA to global change, we examined the relationships between these activities and soil moisture, microbial biomass C and N, and soil extractable N. 3Across all treatment combinations, NEA was decreased by elevated CO2 and increased by N addition. While elevated CO2 had no effect on NEA when not combined with other treatments, it suppressed the positive effect of N addition on NEA in all the treatments that included N addition. We found a significant CO2–N interaction for DEA, with a positive effect of elevated CO2 on DEA only in the treatments that included N addition, suggesting that N limitation of denitrifiers may have occurred in our system. Soil water content, extractable N concentrations and their interaction explained 74% of the variation in DEA. 4Our results show that the potentially large and interacting effects of different components of global change should be considered in predicting below-ground N responses of Mediterranean grasslands to future climate changes.
Quelle croissance de moyen terme après la crise

The financial crisis originated in the United States in 2007 and, then, spread in all the economies of the world. After a drop in activity of historic magnitude, first signs of recovery were recorded in 2009. However, our study of previous banking crises that have taken place in OECD countries over the last forty years leads one to expect a very gradual return of growth rates to their pre-crisis values, with long-lasting losses for the level of GDP. According to our estimations, average losses observed during past banking crises occurred through a reduction in capital stocks, an increase in unemployment rates and a drop in participation rates. Conversely, past banking crises seemed to have had little impact on total factor productivity. In France, the 1992-1993 crisis, which shares some common features with the current crisis, had also long-lasting negative impacts on the employment and unemployment rates. Employment-rate losses were fairly similar for men and women. Ten years passed before the overall unemployment rate returned to its pre-crisis level. Based on various post-crisis scenarios, we illustrate the mechanical medium-term impact of the current crisis on public finances, whithout any fiscal adjustment after 2012. Even in the scenario of a complete recovery by 2018 of GDP losses recorded in 2008 and 2009, the impact on the public debt would exceed 20 % of GDP ten years after the crisis as a result of declining revenues and increasing interest payments. The impact would be still higher in less favourable scenarios.
Estimating the Effects of Selected Sanitary and Phytosanitary Measures and Technical Barriers to Trade on U.S.-EU Agricultural Trade

This study investigates the effects of selected sanitary and phytosanitary measures (SPS) and technical barriers to trade (TBT) on agricultural trade between the United States and the European Union (EU). It identifies data, methodological, and conceptual challenges to quantify such non-tariff measures (NTM) in the context of free-trade agreements. An empirical strategy combining market analysis with gravity model econometric methods is used to quantify the extent of protection afforded by major NTMs in U.S.-EU agricultural trade. In most of the commodities investigated with specific SPS/TBT concerns, estimated ad valorem tariff equivalents (AVE) of NTMs were found to be considerably higher than existing tariffs. EU NTMs on U.S. poultry, pork, and corn were found to have the most trade-impeding effects, with estimated AVE effects of 102, 81, and 79 percent, respectively; EU NTMs on U.S. beef, vegetables, and fruits were also found to be significant. The AVE effect of U.S. NTMs on EU exports ranges from 37 percent for vegetables to 45 percent for fruits.
Tablet vs. Paper: The Effect on Learners' Reading Performance

The purpose of this study is to compare primary school 5 th class students’ electronic text reading performance, reading speed and reading comprehension with tablet PCs and printed books. This study examined a sample of 20 students. The students were randomly divided into two groups, a control group and a treatment group. The control group students read ordinary printed books, and the students in the treatment group read the same text on an electronic tablet PC display. Both qualitative and quantitative data collection tools were used for the study. Qualitative data were collected on the reading speed and reading comprehension skills for both groups of students. Statistically, there was no significant difference between the groups in reading speed or the level of reading comprehension. Students’ opinions on tablet PCs and recommendations for future studies are also discussed.
Exploring dynamic biomedical algorithm of Eurycoma longifolia Jack and its bioactive phytochemicals: A review of pharmacokinetic and pharmacodynamic implications and future prospects

Eurycoma longifolia Jack (E. longifolia) is a well-recognized traditional herbal medicine that offers a wide dynamic range of biomedical applications including anti-osteoporotic, anticancer, anti-proliferative, anti-malarial, antimicrobial, antioxidant, aphrodisiac, anti-inflammatory, anxiolytic, anti-diabetic, anti-rheumatism and anti-ulcer properties. This review aims to overview the pharmacokinetic and a pharmacodynamic algorithm of E. longifolia and its bioactive components. Analysis of pharmacokinetic profile revealed that E. longifolia exhibit higher bioavailability, high volume of distribution, slow elimination rate, and does not show inhibitory effects on cytochrome P450 isoenzymes. E. longifolia has been used, alone or in combination with other pharmacological agents, in the form of crude extracts, standard extracts, or decoctions of different plant parts (i.e., herbs, shrubs, stem, leaves, and roots) for the treatment of various ailments in animals and humans. Among various bioactive constituents, eurycomanone has been found to be the most remarkable, super-stable, versatile, and most potent phytochemical (isolated or extracted from root extracts) against various types of animals and human diseases. Based on its well-established pharmacokinetic and pharmacodynamic profiles, we suggested that E. longifolia can be a well-accepted complementary and alternative medicine for the treatment of different types of human ailments.
Senior secondary school students' risk of disengagement from further education, employment or training

In Western Australia, the school leaving age was mandated to rise from 15 Years to 16 Years in 2007. This policy has resulted in a large number of students remaining at school and entering the senior years of schooling. Of interest in this study were the students who would not normally have remained at school, particularly those who may have disengaged from schooling. A survey instrument was administered to collect data about these students. Data were obtained from school and education district office student services staff on 23 attributes of 5313 Year Ten students identified at risk of not completing schooling, future training or entering employment. The data were dichotomous and the multi-variate nature of these data rendered it unsuitable for Rasch Model analysis but amenable to interpretation using Binomial Logistic Regression. Two models were tested with each containing a different dependent variable and common independent variables. The dependent variables for the respective models were: Model 1 Student Risk of Disengagement; and Model 2 Student Severe Risk of Disengagement. The study identified particular student attributes perceived by school and district office student services staff that statistically predicted two levels of disengagement with schooling, future training or future employment.
Comparison of mortality associated with vancomycin-resistant and vancomycin-susceptible enterococcal bloodstream infections: a meta-analysis.

BACKGROUND Whether vancomycin resistance is independently associated with mortality among patients with enterococcal bloodstream infection (BSI) is controversial. To address this issue, we performed a systematic literature review with meta-analysis. METHODS Data sources were studies identified using the MEDLINE database (for articles from 1988 through March 2003), the Cochrane Library (for articles published up to March 2003), and bibliographies of identified articles. Inclusion criteria were that the study assessed mortality after enterococcal BSI, compared mortality after vancomycin-resistant enterococci (VRE) BSI with that after vancomycin-susceptible enterococci (VSE) BSI, and adjusted for severity of illness. Study exclusion criteria were as follows: no report of the adjusted measure of effect (adjusted odds ratio [OR], adjusted hazard ratio, or adjusted relative risk) of vancomycin resistance on mortality available and/or its adjusted 95% confidence interval (95% CI). Data in the tables, figures, or text were independently extracted by 2 of the authors. Individual weights were calculated using the 95% CI of the adjusted measures of effect performing both fixed-effect and random-effects models. RESULTS Nine studies were eligible (11 studies met the inclusion criteria, and 2 were excluded), with a total of 1614 enterococcal BSI episodes (683 VRE episodes and 931 VSE episodes). Patients with bacteremia caused by VRE were more likely to die than were those with VSE bacteremia (summary OR, 2.52; 95% CI, 1.9-3.4). CONCLUSIONS Vancomycin resistance is independently associated with increased mortality among patients with enterococcal bloodstream infection.
How Specific Is the Connection between Morphological Awareness and Spelling? A Study of French Children.

This study examined the relationship between morphological awareness and spelling. We show that French children in Grades 3 and 4 appear to use morphological information in spelling; spelling of sounds for which there are several alternatives was more accurate in derived than in nonderived words. The link between morphological awareness and spelling seems to be general, given that morphological awareness correlated with multiple spelling scores, including those that did not involve morphology. Further, the relationship between spelling and morphological awareness seems to be affected by both the developmental level of the child and the phonological structure of the items in the morphological awareness task. We discuss the implications of this research for clarifying the relationship between morphological awareness and spelling.
The role of endowments, technology and size in international trade: new evidence from product-level data

ABSTRACT Using product-level trade data, we empirically investigate the export patterns of more than 150 countries in their exports to the USA, Brazil, India, and Japan. We document strong evidence that exporters specialize according to their relative factor endowments, technology, and economic size. More developed, capital abundant countries are found to export products of higher unit values and a wider range of products to developed, emerging and developing markets. More developed, economically larger, and technologically advanced countries are also the major exporters of new products, spanning a wide range of product categories with high unit values. Our findings provide important insights into the macro phenomenon that a large proportion of the global trade takes place among developed economies, and that the latter are also major exporters to developing markets.
The Moderating Effects of Maternal Psychopathology on Children's Adjustment Post–Hurricane Katrina

This study investigated the role of maternal psychopathology in predicting children's psychological distress in a disaster-exposed sample. Participants consisted of 260 children (ages 8–16) recruited from public schools and their mothers. These families were displaced from New Orleans because of Hurricane Katrina in 2005. Assessment took place 3 to 7 months postdisaster. Hierarchical regression analyses revealed that global maternal psychological distress and maternal posttraumatic stress disorder moderated the relation between child hurricane exposure and mother-reported child internalizing and externalizing symptoms.
Effects of Tropospheric Wind Shear on the Spectrum of Convectively Generated Gravity Waves

Abstract The authors examine the effects of tropospheric wind shear on the phase speed spectrum of gravity waves generated by tropical convection. A two-dimensional cloud-resolving model is used to perform numerous squall line simulations with the vertical shear of the horizontal wind varied in three layers of the troposphere. Several simplified simulations using prescribed heating are also performed to elucidate the interactions of wind shear with thermal forcing. It is found that the dominant phase speed range of convectively generated stratospheric gravity waves is primarily determined by the vertical scale of the tropospheric heating and is then modified by the tropospheric wind. The gravity wave spectrum is especially sensitive to shear in the upper troposphere. Through a mechanism similar to critical level filtering, such shear acts to reduce the momentum flux of waves propagating in the same direction as the storm-relative mean wind. Through interaction with convective turrets, shear in the upper t.
Osteoprotegerin Promotes Cementoblastic Activity of Murine Cementoblast Cell Line in vitro.

OBJECTIVE To investigate the effect of osteoprotegerin (OPG) on the cementoblastic activity of a clonal population of immortalised murine cementoblasts (OCCM-30) in vitro. METHODS OCCM-30 cells were transiently transfected with the mouse OPG using the Avalanche transfection reagent. The ectopic expression of OPG was confirmed by enzyme-linked immunosorbent assay and quantitative polymerase chain reaction. The cell counting Kit-8 assay was used to investigate the effect of OPG on cell proliferation. The expression levels of cementoblastic-related mRNA and protein in the transfected OCCM-30 cells were detected using real-time PCR, Western blotting and immunohistochemical staining. RESULTS Satisfactory transfection efficiency was observed 48 h after transfection. The results of the cell proliferation assay indicated that the expansion rate of the OPG transfection group was greater than that of the control group at both 72 h and 96 h. The mRNA levels of osterix (Osx), protein kinase B (Akt1), cementum attachment protein (CAP) and osteopontin (Opn) were significantly upregulated (P < 0.05) in the OPG group. Protein levels of OPN, bone sialoprotein II (BSP II), osteocalcin (OC) and CAP, which are responsible for osteogenetic and cementoblastic activity, were significantly increased in the OPG-overexpressing group. CONCLUSION Overexpression of OPG in OCCM-30 cells promotes cementoblastic activity.
Partial stereotactic ablative boost radiotherapy in bulky non-small cell lung cancer: a retrospective study

Purpose Bulky non-small cell lung cancer (NSCLC) is difficult to achieve effective local control by conventionally fractionated radiotherapy (CRT). The present work aims to evaluate the safety and efficacy of partial stereotactic ablative boost radiotherapy (P-SABR) in bulky NSCLC. Patients and methods From December 2012 through August 2017, 30 patients with bulky NSCLC treated with P-SABR technique were analyzed. The P-SABR plan consisted of one partial SABR plan (5–9 Gy/f, 3–6 fractions) to gross tumor boost (GTVb), followed by one CRT plan to the planning target volume (PTV). GTVb was the max volume receiving SABR to guarantee the dose of organs-at-risks (OARs) falloff to about 3 Gy/f. The total dose of PTV margin was planned to above 60 Gy. The simply CRT plans were created using the same planning parameters as the original plan, with the goal to achieve comparable OARs doses and PTV margin dose to the P-SABR plan. Dosimetric variables were acquired in both P-SABR and compared CRT plans. Toxicity, local control, and survival were also evaluated. Results Median follow-up in survivors was 10.3 months (range=2.3–39.4 months). Eleven patients (36.7%) had partial response (PR) and ten patients (33.3%) had stable disease (SD). Two-year overall survival was 55.6%. Two-year local control rate was 85.7%. No severe acute side effects >CTCAE Grade III were observed. Compared to the simply CRT plan, P-SABR plans achieved similar doses to the OARs and Dmin, but increased dose at the isocenter, Dmean, Dmax, and biological equivalent dose (BED) significantly (P<0.05). BED in the tumor center could reach 107.3 Gy (93.2–132 Gy). Patients with B90≥65% achieved a higher local control rate than those with B90<65% (P=0.010). Conclusion This retrospective study suggests that P-SABR is feasible and well tolerated in bulky NSCLC. Local control rate is encouraging, especially for the B90≥65% group, which may due to the ability of P-SABR to optimize BED with equivalent toxicity.
Severely obese adolescent girls rely earlier on carbohydrates during walking than normal-weight matched girls

Abstract The purpose of this study was to determine the substrate oxidation rate and the exercise intensity at which maximal lipid oxidation and ventilatory threshold (VT) occur in obese (BMI: 36.6 ± 6.3 kg · m−2) and normal-weight adolescent girls (BMI: 18.7 ± 1.6 kg · m−2) aged 14–18 years. Substrate oxidation rate was determined by gas exchange using an incremental field test involving walking. Body composition was assessed by bioelectrical impedance. Carbohydrate oxidation rates were significantly higher in obese than in normal-weight girls at speeds ranging from 4 to 6 km · h−1 (P < 0.05), whereas no significant differences were observed between groups regarding lipid oxidation rates. The crossover point of substrate utilisation and the VT were significantly lower in obese than in normal-weight adolescents (P < 0.05). Maximal lipid oxidation rate was observed at 46 ± 15 and 53 ± 15 %EO2max in obese and normal-weight adolescents, respectively. At these intensities, the Lipoxmax was significantly lower in obese than in normal-weight girls (6.7 ± 2.3 versus 8.9 ± 3.5 mg · min−1 · kg−1 FFM, P < 0.05, 95% CI: −3.7 to −0.7, d = −0.74). The present results have implications in designing interventions to promote lipid oxidation and energy expenditure during walking in severely obese adolescent girls.