Miracle-dz/UniFAR-FTUs huggingface dataset:
Job crafting : de psychologie van een baan op maat

Dit themanummer schenkt aandacht aan een relatief nieuw onderzoeksonderwerp in de Arbeids- en Organisatiepsychologie, namelijk ‘job crafting’. Job crafting heeft betrekking op de aanpassingen die werknemers in hun functie aanbrengen zodat deze beter op de eigen behoeftes en sterktes aansluit. In dit inleidende artikel gaan we eerst in op de inhoud van job crafting. We schetsen beknopt de historische ontwikkeling van het begrip en geven aan hoe het denken over en meten van job crafting zich tot op heden heeft ontwikkeld. Daarna introduceren we de artikelen die in dit themanummer zijn opgenomen. We besluiten met een aantal vragen en thema’s voor toekomstig onderzoek.
Deconstructing negative pressure wound therapy

Since its introduction 20 years ago for the treatment of chronic wounds, negative pressure wound therapy use has expanded to a variety of other wound types. Various mechanisms of action for its efficacy in wound healing have been postulated, but no unifying theory exists. Proposed mechanisms include induction of perfusion changes, microdeformation, macrodeformation, exudate control and decreasing the bacterial load in the wound. We surmise that these different mechanisms have varying levels of dominance in each wound type. Specifically, negative pressure wound therapy is beneficial to acute open wounds because it induces perfusion changes and formation of granulation tissue. Post‐surgical incisional wounds are positively affected by perfusion changes and exudate control. In the context of chronic wounds, negative pressure wound therapy removes harmful and corrosive substances within the wounds to affect healing. When skin grafts and dermal substitutes are used to close a wound, negative pressure wound therapy is effective in promoting granulation tissue formation, controlling exudate and decreasing the bacterial load in the wound. In this review, we elucidate some of the mechanisms behind the positive wound healing effects of negative pressure wound therapy, providing possible explanations for these effects in different wound types.
Working Models of Attachment in Psychiatrically Hospitalized Adolescents: Relation to Psychopathology and Personality.

ABSTRACT This study examined the role of attachment in adolescent psychopathology among psychiatrically hospitalized adolescents. Subjects consisted of 60 adolescents and 27 of their mothers. Measures included the Adult Attachment Interview classification for both the adolescents and their mothers, and a battery of diagnostic and personality assessment of the adolescents. The findings revealed that the quality of adolescent attachment relationships with parents was strongly related to both clinical diagnosis and persona.ity dimensions. A striking similarity between patients' and mothers' attachment classification also was found. Adolescents whose attachment organization was Dismissing relied upon a strategy of defensive exclusion from awareness of information which portrayed attachment relationships in a negative light. This strategy was shared by adolescent with externalizing disorders (conduct disorder, substance abuse) and by Narcissistic and Antisocial Personality Disorders and traits. Adolescents in the Preoccupied group were extremely sensitive to difficulties in their attachment relationships and overwhelmed by negative perceptions of parents. These patients were likely to have an Affective Disorder, Obsessive -Cc ? ulsive, Histrionic, Borderline, and Schizotypal Personality Disorders, and dependent, avoidant, schizotypal, and dysthymic personality traits. (NB)
Think abstractly, smoke less: a brief construal-level intervention can promote self-control, leading to reduced cigarette consumption among current smokers.

AIMS Inadequate self-control has been linked to behavioural and impulse-control problems such as overeating, alcohol and drug abuse and smoking. Construal-level theory (CLT) suggests that a high-level construal (highlighting central goals associated with an event), relative to a low-level construal (highlighting means and resources), promotes self-control. Inspired by CLT, we examined whether smokers primed with a high-level (versus low-level) construal mind-set would show reductions in smoking that might be mediated by improved self-control. DESIGN A single-factor (construal level: high, low, control) between-subjects design was employed. We used a widely employed why/how paradigm to induce high/low construal levels, whereby participants were asked to respond to questions about 'why' or 'how' they would maintain good physical health. SETTING Laboratory at Kaohsiung Medical University, Taiwan. PARTICIPANTS A community sample consisting of 102 daily smokers participated in this experiment. MEASUREMENTS The Stroop task measuring self-control was implemented after the construal-level manipulation. The dependent measure was actual cigarette consumption during an ostensible survey. FINDINGS Participants in a high-level construal mind-set smoked fewer cigarettes [mean = 1.3, 95% confidence interval (CI): 0.9, 1.7] than those in a low-level construal mind-set (mean = 2.6, 95% CI: 2.2, 3.0; P < 0.01). A bootstrapping analysis supported for the role of self-control (B = -1.14, 95% CI: -1.65, -0.74, P < 0.01) as a mechanism underlying this effect. CONCLUSIONS Smokers primed with a high-level construal mind-set (i.e. cognitive abstraction) may induce greater self-control that leads to reduced cigarette consumption. Thus, reminding smokers to think abstractly about health may be an effective strategy that could help them to smoke fewer cigarettes.
Low-frequency versus high-frequency synchronisation in chirp-evoked auditory brainstem responses

This study investigates the frequency specific contribution to the auditory brainstem response (ABR) of chirp stimuli. Frequency rising chirps were designed to compensate for the cochlear traveling wave delay, and lead to larger wave-V amplitudes than for click stimuli as more auditory nerve fibres fire synchronously. Traditional click stimuli were believed to only excite high-frequency fibres synchronously. It is still currently unclear whether the broad-band chirp stimulus leads to increased synchronisation of both low- and high-frequency fibres. It is also unclear if both these groups of fibres contribute significantly to the overall wave-V amplitude. In the present study, ABRs were recorded from 10 normal-hearing listeners using low- and high-frequency band-limited chirps and clicks (0.1 – 1.5 kHz and 1.5 - 10 kHz) presented at a level of 40 dB HL. The results showed significantly larger wave-V amplitudes for both low and high-frequency band-limited chirps than for the filtered clicks. This demonstrates that the synchronisation of nerve fibres occurs across the entire frequency range at this presentation level, and this leads to significant increases in wave-V amplitudes. The increase for the low-frequency chirp was found to be clearly larger than that obtained at the higher frequencies.
Reverse-Genetic Analysis of the Two Biotin-Containing Subunit Genes of the Heteromeric Acetyl-Coenzyme A Carboxylase in Arabidopsis Indicates a Unidirectional Functional Redundancy1[C][W][OA]

The heteromeric acetyl-coenzyme A carboxylase catalyzes the first and committed reaction of de novo fatty acid biosynthesis in plastids. This enzyme is composed of four subunits: biotin carboxyl-carrier protein (BCCP), biotin carboxylase, α-carboxyltransferase, and β-carboxyltransferase. With the exception of BCCP, single-copy genes encode these subunits in Arabidopsis (Arabidopsis thaliana). Reverse-genetic approaches were used to individually investigate the physiological significance of the two paralogous BCCP-coding genes, CAC1A (At5g16390, codes for BCCP1) and CAC1B (At5g15530, codes for BCCP2). Transfer DNA insertional alleles that completely eliminate the accumulation of BCCP2 have no perceptible effect on plant growth, development, and fatty acid accumulation. In contrast, transfer DNA insertional null allele of the CAC1A gene is embryo lethal and deleteriously affects pollen development and germination. During seed development the effect of the cac1a null allele first becomes apparent at 3-d after flowering, when the synchronous development of the endosperm and embryo is disrupted. Characterization of CAC1A antisense plants showed that reducing BCCP1 accumulation to 35% of wild-type levels, decreases fatty acid accumulation and severely affects normal vegetative plant growth. Detailed expression analysis by a suite of approaches including in situ RNA hybridization, promoter:reporter transgene expression, and quantitative western blotting reveal that the expression of CAC1B is limited to a subset of the CAC1A-expressing tissues, and CAC1B expression levels are only about one-fifth of CAC1A expression levels. Therefore, a likely explanation for the observed unidirectional redundancy between these two paralogous genes is that whereas the BCCP1 protein can compensate for the lack of BCCP2, the absence of BCCP1 cannot be tolerated as BCCP2 levels are not sufficient to support heteromeric acetyl-coenzyme A carboxylase activity at a level that is required for normal growth and development.
Smoothness beyond di erentiability

Fundamental Theorem of Analysis Theorem 1. Suppose that f ∈ H(0, 1). Then there exists a g ∈ L2(0, 1) such that f(x)− f(0) = ∫ x 0 g(t) dt, 0 < x < 1. We de ne the linear mapping (Sg)(x) := ∫ x 0 g(t) dt. Corollary 1. If f ∈ H(0, 1) then f − f(0) ∈ R(S). Thus, smoothness means that f is in the range of a smoothing operator. Theorem 2. Suppose that f ∈ H(0, 1) (periodic). For the Fourier coe cients f̂(n) of f it holds ∑∞ n=1 n 2 ∣∣∣f̂(n)∣∣∣2 <∞. Corollary 2. Smoothness implies a certain decay of the Fourier coe cients. Goal 1. Make a general theory from these observations!
Current issues in morphological processing

1. The Role of Semantic Transparency in the Processing of Finnish Compound Words 2. Discontinuous Morphology in Time: Incremental Masked Priming in Arabic 3. Morphological Parafoveal Preview Benefit Effects in Reading: Evidence from Hebrew 4. A Roommate in Cream: Morphological Family Size Effects on Interlingual Homograph Recognition 5. The Role of Interword Spaces in the Processing of English Compound Words 6. Priming Morphologically Complex Verbs by Sentence Contexts: Effects of Semantic Transparency and Ambiguity 7. Are Stem Homographs and Orthographic Neighbors Processed Differently During Silent Reading? 8. The Locus and Time Course of Long-term Morphological Priming 9. Marked Cross-modal Morphological Priming: Unravelling Morpho-orthographic and Morpho-semantic Influences in Early Word Recognition 10. Where does Gender come from? Evidence from a Complex Inflectional System 11. The Processing of Root Morphemes in Hebrew: Contrasting Localist and Distributed Accounts 12. Prosodic Cues for Morphologiacl Complexity in Dutch and English 13. Changing Morphological Structures: The Effect of Sentence Context on the Interpretation of Structurally Ambiguous English Trimorphemic Words.
Plant Immunity Requires Conformational Charges of NPR1 via S-Nitrosylation and Thioredoxins

Changes in redox status have been observed during immune responses in different organisms, but the associated signaling mechanisms are poorly understood. In plants, these redox changes regulate the conformation of NPR1, a master regulator of salicylic acid (SA)–mediated defense genes. NPR1 is sequestered in the cytoplasm as an oligomer through intermolecular disulfide bonds. We report that S-nitrosylation of NPR1 by S-nitrosoglutathione (GSNO) at cysteine-156 facilitates its oligomerization, which maintains protein homeostasis upon SA induction. Conversely, the SA-induced NPR1 oligomer-to-monomer reaction is catalyzed by thioredoxins (TRXs). Mutations in both NPR1 cysteine-156 and TRX compromised NPR1-mediated disease resistance. Thus, the regulation of NPR1 is through the opposing action of GSNO and TRX. These findings suggest a link between pathogen-triggered redox changes and gene regulation in plant immunity.
COMPUTATIONAL ANALYSIS OF BLOOD FLOW DYNAMICS IN CEREBRAL ANEURYSMS FROM CTA AND 3 D ROTATIONAL ANGIOGRAPHY IMAGE DATA

Detailed knowledge of the hemodynamics in cerebral aneurysms is valuable not only for understanding their formation and rupture but also for clinical evaluation and treatment. However, important hemodynamic quantities are difficult to measurein vivo. In this paper we present a methodology for modeling patient-specific blood flows in cerebral aneurysms that combines medical image analysis and finite element methods. Intracranial aneurysms are segmented from either CTA or 3D rotational angiography images using implicit deformable models. Unstructured grids are constructed from the segmented images and computational fluid dynamics analysis are performed under realistic pulsatile flow conditions.
A Security Protocol for Mobile E-service Oriented Architecture (MSOA): Design and Implementation

In this paper, it first analyzes the present security protocol for mobile communications. Furthermore, a security framework for the mobile E-Service is proposed. In the mean time, using the inherent security and expansibility of J2ME, we design a security message flow model to support communication protocol for the Mobile E-Service Oriented Architecture (MSOA), which emphasizes the authentication and the security of information transmission to the cooperative mobile users. Finally, under the background application of county-level mobile E-Service platform, we validate the security and feasibility of the communication protocol, thus providing firm and satisfactory technical support for the county-level mobile E-Government system.
Dual–Dual Action? Combining Venlafaxine and Mirtazapine in the Treatment of Depression

Objective: Venlafaxine and mirtazapine in combination are increasingly used in clinical practice to treat treatment-refractory depression. Putative efficacy for this combination of antidepressants, beyond that of monotherapy, stems from their synergistic actions. This paper describes a prospective case series that examined the efficacy of the venlafaxine–mirtazapine combination in the treatment of depressed patients who had failed at least one antidepressant trial. Method: Twenty-two depressed patients with major depression were treated with venlafaxine and mirtazapine in combination for an average of just under 8weeks. Baseline ratings on the 17-item Hamilton Depression Rating Scale (HAM-D17), Montgomery–Åsberg Depression Rating Scale (MADRS) and the Clinical Global Impression–Severity Scale (CGI-S) were repeated at end-point, determined by the naturalistic termination of the depressive treatment episode or the discontinuation of the combination treatment due to adverse effects. The length of treatment until end-point was documented for each patient. Descriptive statistics were used on the collated data. Results: At baseline, mean scores were 28.8 (SD=3.8) for HAM-D17, 30.1 (SD=5.8) for MADRS, and 4.5 (SD=0.5) for CGI-S, reflecting a cohort at the moderate to severe end of the spectrum. At end-point, mean absolute scores were 10.2 (SD=4.7) for HAM-D17, 10.8 (SD=4.6) for MADRS, and 2.3 (SD=0.6) for CGI-S. Mean change from baseline was 18.6 (SD=6.4) for HAM-D17, 19.3 (SD=6.8) for MADRS, and 2.3 (SD=0.6) for CGI-S. Mean duration of treatment was approximately 8weeks, producing a response rate of 81.8% and a remission rate of 27.3%. Only one patient was unable to tolerate the combination although nearly half (10) had significant side-effects during treatment. Conclusion: This study demonstrates relatively high response and remission rates that are encouraging and contribute to the efficacy database for this antidepressant combination. Further studies using randomized controlled designs are needed.
China's State-Owned Banks' Lending Practices, 1994-2005: Empirical Tests and Policy Implications

More than half of the assets in China's banking system are accounted for by four huge state-owned commercial banks. This paper examines the changing factors influencing these banks' lending behavior over the post-1994 period on a province-by-province basis. Determinants include the concentration of state-owned enterprises, the level of provincial prosperity, deposit levels, and macroeconomic control variables. We confirm a downward trend in the banks' loan-to- deposit ratio combined with some (mixed) evidence of more lending to richer provinces over time. SOE lending remained important for at least one of the four banks.
Identity and Freedom: Mapping Nationalism and Social Criticism in Twentieth Century Lithuania

Foreword Alfred Erich Senn 1. Between Identity and Freedom: Mapping Nationalism in Twentieth-Century Lithuania 2. Vytautas Kavolis Liberalism, Nationalism and the Polylogue of Civilisations 3. Aleksandras Shtromas Liberal Nationalism and the Politics of Dissent 4. Tomass Venclova Ethical Universalism and the Discovery of the Other
Controversies in the management of pediatric liver disease: Hepatitis B, C and NAFLD: Summary of a single topic conference

The AASLD Hepatitis Single Topic Conference (STC) entitled “Controversies in the Management of Pediatric Liver Disease: Hepatitis B,C and NAFLD,” was held at the Emory Conference Center on March 3 and 4, 2006. The conference was organized to juxtapose the current state-of-the-art in the management of pediatric liver disease with evidenced-based approaches that exist for the same problems in adults. The principal goal of the conference was to assess critically current management of hepatitis B and C, and NAFLD in children, since evidence-based approaches are generally lacking. The conference included formal didactic presentations by experts (Table 1A-C) and informal active discussions between faculty and conference participants. The informal discussions were very animated and educational including both question and answer sessions and case discussions. Herein, we synthesize some of the information presented during the proceedings. Our aim with this summary is to highlight salient issues that were discussed in the STC rather than present a comprehensive review of the topics or formulate consensus statements. Individual sections have been reviewed by the faculty for that particular section, although they are not co-authors per se. The success of the conference was due in large part to the active exchange of information that took place between faculty and the participants.
Probabilistic Classifiers for Tracking Point of View

This paper describes work in developing probabilistic classifiers for a discourse segmentation problem that involves segmentation, reference resolution, and belief. Specifically, the problem is to segment a text into blocks such that all subjective sentences in a block are from the point of view of the same agent, and to identify noun phrases that refer to that agent. In our method for developing classifiers (Bruce & Wiebe 1994ab), rather than making assumptions about which variables to use and how they are related, statistical techniques are used to explore these questions empir-icaily. Further, the types of models used in this work can express complex relationships among diverse sets of variables. This work is part of a large project that is in an early stage of development. The contributions of this paper are an illustration of framing a high-level discourse problem in such a way that it is amenable to statistical processing while still retaining its core, and a description of a method for developing probabilistic classifiers that is well-suited for addressing problems in discourse processing.
A prospective study of risk factors for cardiovascular events among the elderly

Objective To analyze the impact of cardiovascular (CV) risk factors on the occurrence of fatal and non-fatal CV events in elderly individuals. Methods The present research was a prospective cohort study of 800 elderly Brazilian outpatients (60 to 85 years old) with a 12-year follow-up period (baseline: 1997–1998). The outcome variable was CV mortality or non-fatal CV events (stroke, infarction, angina, heart failure). Hypertension, diabetes, global and abdominal obesity, dyslipidemias, and metabolic syndrome were analyzed as independent variables. The analyses were based on Cox proportional hazard models and adjusted for gender, age range, smoking, regular physical activity, and previous cardiovascular disease. Results A total of 233 fatal and non-fatal CV events were observed (29.1%). In the adjusted analysis, the following variables were associated with CV risk: hypertension hazard ratio (HR): 1.69; confidence interval (CI) 95%: 1.28–2.24, diabetes (HR: 2.67; CI 95%: 1.98–3.61), metabolic syndrome (HR: 1.61; CI 95%: 1.24–2.09), abdominal obesity (HR: 1.36; CI 95%: 1.03–1.79), hypertriglyceridemia (HR: 1.67; CI 95%: 1.22–2.30) and high triglyceride/HDL-c ratio (HR: 1.73; CI 95%: 1.31–2.84). Hypertension, diabetes, and dyslipidemia remained associated with CV risk regardless of abdominal obesity. Conclusion In this prospective study, hypertension, diabetes, metabolic syndrome, abdominal obesity, and hypertriglyceridemia were predictors of CV risk in elderly individuals. These results confirm the relevance of controlling these CV risk factors in this age group.
Hydrophobic Oxime Ethers: A Versatile Class of pDNA and siRNA Transfection Lipids

The manipulation of the cationic lipid structures to increase polynucleotide binding and delivery properties, while also minimizing associated cytotoxicity, has been a principal strategy for developing next‐generation transfection agents. The polar (DNA binding) and hydrophobic domains of transfection lipids have been extensively studied; however, the linking domain comprising the substructure used to tether the polar and hydrophobic domains has attracted considerably less attention as an optimization variable. Here, we examine the use of an oxime ether as the linking domain. Hydrophobic oxime ethers were readily assembled via click chemistry by oximation of hydrophobic aldehydes using an aminooxy salt. A facile ligation reaction delivered the desired compounds with hydrophobic domain asymmetry. Using the MCF‐7 breast cancer, H1792 lung cancer and PAR C10 salivary epithelial cell lines, our findings show that lipoplexes derived from oxime ether lipids transfect in the presence of serum at higher levels than commonly used liposome formulations, based on both luciferase and green fluorescent protein (GFP) assays. Given the biological compatibility of oxime ethers and their ease of formation, this functional group should find significant application as a linking domain in future designs of transfection vectors.