Miracle-dz/UniFAR-FTUs huggingface dataset:
A Triggering Mechanism for the Indian Ocean Dipoles Independent of ENSO

AbstractAlthough the Indian Ocean dipole (IOD) and ENSO are significantly correlated, there are indeed some IODs independent of ENSO. In this research, the characteristics of independent IOD are investigated and a new triggering mechanism is proposed based on case study and statistical analysis. Results show that the independent IODs peak in an earlier season and have a weaker intensity compared with the IODs associated with ENSO. The wind anomaly associated with the independent IOD is very unique and shows a monsoonlike pattern, in addition to the equatorial easterly wind anomaly (EEWA) common to all IODs. The evolution of the EEWA associated with the independent IOD is well captured by the second EOF mode of the equatorial zonal wind interannual variability, suggesting that the independent IOD is an important climate mode inherent to the tropical Indian Ocean. The EEWA associated with the independent IOD is tightly linked to Indian summer monsoon activities in spring, and the convection anomalies associ.
Investigating the factors influencing food waste behavior in the Egyptian society

PurposeIt is globally recognized that food waste has significant economic, social and environmental impacts. This study endeavors to identify the individuals' underlying factors that affect food waste behavior in a social context in Egypt.Design/methodology/approachDue to the scarcity of research illustrating food waste in a social context, a qualitative research paradigm is employed. In-depth semi-structured interviews are conducted with 18 Egyptian households to report their experiences, thoughts and feelings while eating in a social context.FindingsBased on thematic analysis using grounded theory procedures, eight main elements affecting creation and reduction of food waste in social contexts are identified. Additionally, the authors investigate the role of emotions in social dining contexts. A key finding is that food waste in social events is inevitable and is the acceptable norm in the Egyptian culture. Thus, the first step to reduce food waste is paying more attention to change culture. Persuading people with the negative consequences of food waste issue on behalf of their cultural values will be more challenging and may require more innovative approaches.Originality/valueAlthough food waste issue is one of the contemporary issues in the world, very little is known about how social food consumption leads to food waste behavior. This study employs social influence theory and the collectivistic culture orientation to investigate the unanswered question of why food gets wasted in social meal context.
Sex Differences in Brain Region-Specific Activation of c-Fos following Kappa Opioid Receptor Stimulation or Acute Stress in Mice

Kappa opioid receptors (KOPr) are involved in the response to stress. KOPr are also targets for the treatment of stress-related psychiatric disorders including depression, anxiety, and addiction although effects of KOPr are often sex-dependent. Here we investigated c-Fos expression in a range of brain regions in male and female mice following an acute stressor, and a single injection of KOPr agonist. Using adult C57BL/6 c-Fos-GFP transgenic mice and quantitative fluorescence microscopy, we identified brain regions activated in response to a challenge with the KOPr agonist U50,488 (20 mg/kg) or an acute stress (15 min forced swim stress, FSS). In male mice, U50,488 increased expression of c-Fos in the prelimbic area of the prefrontal cortex (PFCx), nucleus accumbens (NAcc), and basolateral nuclei of the amygdala (BLA). In contrast, in female mice U50,488 only activated the BLA but not the PFCx or the NAcc. FSS increased activation of PFCx, NAcc, and BLA in males while there was no activation of the PFCx in female mice. In both sexes, the KOPr antagonist norBNI significantly blocked U50,488-induced, but not stress-induced activation of brain regions. In separate experiments, activated cells were confirmed as non-GABAergic neurons in the PFCx and NAcc. Together these data demonstrate sex differences in activation of brain regions that are key components of the ‘reward’ circuitry. These differential responses may contribute to sex differences in stress-related psychiatric disorders and in the treatment of depression, anxiety, and addiction.
Efficacy and Safety of Transcutaneous Electrical Nerve Stimulation in Patients Undergoing Inguinal Hernia Repair: A Systematic Review and Meta-analysis

Background: Postoperative pain is a major cause of delayed recovery following inguinal hernia repair. Transcutaneous electrical nerve stimulation (TENS) is a simple, low-cost method of noninvasive analgesia. This study aimed to assess the efficacy and safety of TENS for pain management following inguinal hernia repair. Methods: We searched nine electronic databases and trial registries to identify randomized controlled trials (RCTs). The primary outcomes were postoperative pain and the use of rescue analgesics. The Risk of Bias 2 tool was used to evaluate the risk of bias in the included trials. The certainty of the evidence was assessed using Grading of Recommendations, Assessment, Development, and Evaluations (GRADE). Subgroup analyses were conducted based on the anesthesia type or TENS dose and frequency. This study is registered with PROSPERO (CRD42022353932). Results: Eleven RCTs, with a total of 559 patients, were included. The overall risk of bias was concerning due to the lack of information about concealment or published protocols. TENS may reduce pain on postoperative day (POD) 0 (standardized mean difference [SMD], −2.14; 95% confidence interval [CI], −3.54 to −0.73; moderate certainty of the evidence), POD 1 (SMD, −1.22; 95% CI, −1.92 to −0.52; moderate certainty of the evidence), and POD 2 (SMD, −0.97; 95% CI, −2.04 to 0.10; low certainty of the evidence). According to the subgroup analyses, postoperative pain was reduced, particularly with local anesthesia or repetitive and frequent TENS (P < 0.05). TENS may result in little-to-no difference in rescue analgesic use (risk ratio, 0.75; 95% CI, 0.47-1.18; low certainty of the evidence). No serious adverse events occurred (moderate certainty of the evidence). Conclusions: TENS may reduce pain in patients who have undergone inguinal hernia repair. Further trials are warranted to confirm our findings.
A gridded reconstruction of land and ocean precipitation for the extended tropics from 1974 to 1994

This paper describes a new 3.75° longitude by 2.5° latitude gridded monthly precipitation data series for the extended tropical region from 30°N to 30°S and covering the period 1974-1994. This new dataset combines the pre-existing land-based 3.75° x 2.5° resolution gridded monthly precipitation series of Hulme for the period 1974-1994, with a new monthly oceanic precipitation climatology, constructed from satellite outgoing longwave radiation (OLR) measurements also for the period 1974-1994. This latter dataset, which has been calibrated against available atoll raingauge observations, provides the longest record of satellite-derived precipitation estimates. A mean reliability index field to accompany this OLR-derived climatology is created from comparisons performed with two other satellite-derived precipitation datasets: the microwave sounding unit (MSU) precipitation dataset of Spencer and the preliminary global precipitation climatology project (GPCP) dataset developed at the Global Precipitation Climatology Centre. A Poisson blending technique is used to merge the land- and OLR-derived oceanic precipitation datasets to produce an extended tropical region climatology, suitable for global climate model validation and for other climatological analyses. This blended dataset shows good agreement with the GPCP product over the tropical region for the years 1986-1993.
Long-term changes of precipitation in Latvia

This study investigated long-term variability and trends in Latvia9s annual, seasonal, monthly and daily precipitation using data from 10 meteorological stations for the period 1925–2006 and from station Riga University for the period 1850–2006. The obtained results indicate that during the 20th century a significant increase in precipitation has occurred in the cold season while the warm period showed a decreasing tendency. The annual precipitation totals showed a slight decrease, at half of the studied stations, due to opposite tendencies in cold season and warm season. The long-term trend in the annual precipitation in Riga (from 1850) was positive with large interannual and interdecadal variability. The extreme precipitation events were evaluated using a set of nine climate change indices. Of these, number of wet days, 1-day and 5-days maximum precipitation, moderate wet days and very wet days showed a well pronounced positive tendency in the cold period of the year particularly in winter. No overall long-term trend was detected in extreme precipitation in summer. As in the case of 150-year precipitation pattern, extreme precipitation exhibited cyclic fluctuations that were more pronounced than linear changes. The close correlation between North Atlantic oscillation (NAO) and extreme precipitation was found for winter season.
A Narrative Review on CD44’s Role in Glioblastoma Invasion, Proliferation, and Tumor Recurrence

Simple Summary As recurrence in glioblastoma is locally generated around the resection cavity, surviving glioma stem-like cells may cause recurrence. Glioma stem-like cells expressing high levels of CD44 are highly invasive and are required to change to less invasive, more proliferative types to generate a recurrent tumor. CD44 promotes both the invasion and proliferation of tumor cells via various signaling pathways. Among these, paired pathways show reciprocal activation of invasion and proliferation under different conditions of oxygenation. Severe hypoxia activates genes related to cell invasion, whereas moderate hypoxia activates genes related to cell proliferation. CD44 is associated with both pathways and plays a critical role in regulating the balance between the promotion of cell invasion and cell proliferation. These results may indicate that CD44 is a key molecule for executing tumor recurrence in glioblastoma. Abstract High invasiveness is a characteristic of glioblastoma (GBM), making radical resection almost impossible, and thus, resulting in a tumor with inevitable recurrence. GBM recurrence may be caused by glioma stem-like cells (GSCs) that survive many kinds of therapy. GSCs with high expression levels of CD44 are highly invasive and resistant to radio-chemotherapy. CD44 is a multifunctional molecule that promotes the invasion and proliferation of tumor cells via various signaling pathways. Among these, paired pathways reciprocally activate invasion and proliferation under different hypoxic conditions. Severe hypoxia (0.5–2.5% O2) upregulates hypoxia-inducible factor (HIF)-1α, which then activates target genes, including CD44, TGF-β, and cMET, all of which are related to tumor migration and invasion. In contrast, moderate hypoxia (2.5–5% O2) upregulates HIF-2α, which activates target genes, such as vascular endothelial growth factor (VEGF)/VEGFR2, cMYC, and cyclin D1. All these genes are related to tumor proliferation. Oxygen environments around GBM can change before and after tumor resection. Before resection, the oxygen concentration at the tumor periphery is severely hypoxic. In the reparative stage after resection, the resection cavity shows moderate hypoxia. These observations suggest that upregulated CD44 under severe hypoxia may promote the migration and invasion of tumor cells. Conversely, when tumor resection leads to moderate hypoxia, upregulated HIF-2α activates HIF-2α target genes. The phenotypic transition regulated by CD44, leading to a dichotomy between invasion and proliferation according to hypoxic conditions, may play a crucial role in GBM recurrence.
Long-term observations of transport, eddies, and Rossby waves in the Mozambique Channel

Data from an array of current meter moorings covering a period of two and a half years are used to estimate the varying transport through the Mozambique Channel. The total transport during this period is small. Below 1200 m the transport is weak but a prominent deep western boundary undercurrent with cores at 1700 and 2200 m is found that transports 1.5 Sv to the north. The transport shows a large temporal variability, and neither a continuous upper layer western boundary current nor a continuous deep undercurrent is found. The variability in the upper layer is dominated by a period of 68 days and results mainly from eddies that migrate southward through the Mozambique Channel. In addition to this southward propagation, a westward-propagating signal is evident from a space-time diagram of the throughflow. The signal is interpreted as a Mozambique Channel Rossby normal mode. This interpretation is consistent with results from a Principal Oscillation Pattern Analysis (that estimates normal modes from the data) and a quasi-geostrophic channel model. A detailed inspection of a single ‘‘eddy event’’ shows that a precursor of an anticyclone is a strong southward current along the Madagascar coast that propagates westward to the center of the Channel. During the westward propagation, the current becomes unstable inducing an anticyclone. This scenario connects the westward-propagating mode with the eddy growth and explains the coincidence of the eddy and Rossby mode frequency.
Efficient visualization of LIDAR datasets

The purpose of presented point-based rendering method is to visualize data retrieved from 3D scanners, especially from Light Detection and Ranging (LIDAR) scanners. LIDAR data scanners capture highly accurate and dense data and are used to gather vast spatial information about geographical areas. As a result, a lot of points are obtained and optimization techniques are needed for their real-time visualization. Fully interactive system with high frames-per-second (FPS) ratio is presented in this paper. The efficiency is achieved by reduction of a graphics workload, based on space subdivision, using a quad-tree. The points maintained in the leaves of the quad-tree are aligned evenly through nine or more depth-levels, depending on the number of points in the leaf. Such subdivision allows effective control of level-of-details (LOD) as it minimizes the number of calculations, needed for the visualization in real-time. The changes in the organization of data during the run-time are very rare and therefore, the LOD hierarchy can be established in the preprocessing. A method for achieving a detailed look of the scene, even at low LOD degree, is implemented, too.
A Nonlinear Theory of the Kuroshio Extension Bimodality

Abstract The Kuroshio Extension (KE) flow in the North Pacific Ocean displays a very distinctive decadal variability of bimodal character involving two completely different states (a large-meander “elongated” state and a small-meander “contracted” state) connected by very asymmetric temporal transitions. Although such a flow has been widely studied by means of a suite of mathematical models and by using several observational platforms, a satisfactory theoretical framework answering quite elementary questions is still lacking, the main question being whether such variability is induced by a time-varying wind forcing or, rather, by intrinsic oceanic mechanisms. In this context, the chaotic relaxation oscillation produced by a process-oriented model of the KE low-frequency variability, with steady climatological wind forcing, was recently recognized to be in substantial agreement with altimeter data. Here those model results are further compared with a comprehensive altimeter dataset. The positive result of .
Microdiversity sustains the distribution of rhizosphere-associated bacterial species from the root surface to the bulk soil region in maize crop fields

Over the years, the microbial community of maize (Zea mays) rhizosphere has been extensively studied; however, the role of microdiversity sustain rhizosphere-associated microbial species distribution from root surface to bulk soil in mature maize is still unclear. Although operational taxonomic units (OTUs) have been used to classify species, amplicon sequence variants (ASVs) have been shown to be effective in representing microdiversity within OTUs at a finer genetic scale. Therefore, the aim of this study was to examine the role of microdiversity in influencing the distribution of rhizosphere-associated microbial species across environmental gradients from root surface to bulk soil at the OTU and ASV levels. Here, the microbial community structures of bulk, loosely bound, and tightly bound soil samples from maize rhizosphere were examined at OTU and ASV levels. The results showed that OTU and ASV methods exhibited similar microbial community structures in rhizosphere. Additionally, different ecotypes with varying distributions and habitat preferences were observed within the same bacterial OTU at the ASV level, indicating a rich bacterial microdiversity. In contrast, the fungal community exhibited low microdiversity, with no significant relationship between fungal microdiversity and persistence and variability. Moreover, the ecotypes observed within the bacterial OTUs were found to be positively or negatively associated with environmental factors, such as soil organic carbon (SOC), NO3 −–N, NH4 +–N contents, and pH. Overall, the results showed that the rich microdiversity could sustain the distribution of rhizosphere-associated bacterial species across environmental gradients from root surface to bulk soil. Further genetic analyses of rhizosphere-associated bacterial species could have considerable implications for potential mediation of microdiversity for sustainable crop production.
Multilayer, Broadband Infrared Reflectors Based on the Photoinduced Preparation of Cholesteric Liquid Crystal Polymers

This paper focuses on preparing broadband reflective liquid crystal films through the diffusion of monofunctional and bifunctional monomers in a photoinduced trilayer system. By combining the hydrophilic and hydrophobic liquid crystal glass surface treatment technologies, the polymer network of polymer-stabilized cholesteric liquid crystal (PSCLC) itself serves as a diffusion channel to form a trilayer cholesteric liquid crystal composite system containing bifunctional monomers, a nematic liquid crystal composite system, and a cholesteric liquid crystal composite system containing monofunctional monomers. Utilizing the difference in the polymerization rates of monofunctional and difunctional polymerizable monomers, the monomers and chiral compounds diffuse relative to each other, so that the liquid crystal pitch exhibits a gradient distribution, and the broadened reflective width can reach up to 1570 nm. There is no doubt that new and improved processes and technologies offer important possibilities for preparing and applying PSCLC films.
Probiotics and Probiotic-like Agents against Chemotherapy-Induced Intestinal Mucositis: A Narrative Review

Cancer chemotherapy has allowed many patients to survive, but not without risks derived from its adverse effects. Drugs, such as 5-fluorouracil, irinotecan, oxaliplatin, methotrexate, and others, as well as different drug combinations trigger intestinal mucositis that may cause or contribute to anorexia, pain, diarrhea, weight loss, systemic infections, and even death. Dysbiosis is a hallmark of chemotherapy-induced intestinal mucositis and diarrhea, and, therefore, strategies aimed at modulating intestinal microbiota may be useful to counteract and prevent those dreadful effects. This narrative review offers an overview of the studies performed to test the efficacy of probiotics and probiotic-like agents against chemotherapy-induced intestinal mucositis and its consequences. Microbiota modulation through the oral administration of different probiotics (mainly strains of Lactobacillus and Bifidobacterium), probiotic mixtures, synbiotics, postbiotics, and paraprobiotics has been tested in different animal models and in some clinical trials. Regulation of dysbiosis, modulation of epithelial barrier permeability, anti-inflammatory effects, modulation of host immune response, reduction of oxidative stress, or prevention of apoptosis are the main mechanisms involved in their beneficial effects. However, the findings are limited by the great heterogeneity of the preclinical studies and the relative lack of studies in immunocompromised animals, as well as the scarce availability of results from clinical trials. Despite this, the results accumulated so far are promising. Hopefully, with the aid of these agents, intestinal mucositis will be less impactful to the cancer patient in the near future.
Predicting Beach Erosion as a Function of Rising Water Level: Reply

A model has been constructed to predict the horizontal distance of shoreline recession that occurs when a beach and nearshore zone in dynamic equilibrium is subjected to a rise in water level. The horizontal distance of shoreline recession (X) is inversely proportioned to the angle of the nearshore slope seaward from breaking waves ($$\phi$$), and directly proportioned to the rise in water level (a): $$X = a/Tan \phi$$ The volume of sediment eroded from the beach is equal to the volume of sediment deposited in the nearshore up to and including the position where waves break: Xh = ab where h is the vertical distance from the foreshore crest to the foreshore base, and b is the distance from the foreshore base to the position of breaking waves.
A Reappraisal of the Effects of L-type Ca2+ Channel Blockers on Store-Operated Ca2+ Entry and Heart Failure.

Dihydropyridines such as amlodipine are widely used as antihypertensive agents, being prescribed to ∼70 million Americans and >0.4 billion adults worldwide. Dihydropyridines block voltage-gated Ca2+ channels in resistance vessels, leading to vasodilation and a reduction in blood pressure. Various meta-analyses show that dihydropyridines are relatively safe and effective in reducing hypertension. The use of dihydropyridines has recently been called into question as these drugs appear to activate store-operated Ca2+ entry in fura-2-loaded nonexcitable cells, trigger vascular remodeling, and increase heart failure, leading to the questioning of their clinical use. Given that hypertension is the dominant "silent killer" across the globe affecting ∼1.13 billion people, removal of Ca2+ channel blockers as antihypertensive agents has major health implications. Here, we show that amlodipine has marked intrinsic fluorescence, which further increases considerably inside cells over an identical excitation spectrum as fura-2, confounding the ability to measure cytosolic Ca2+. Using longer wavelength Ca2+ indicators, we find that concentrations of Ca2+ channel blockers that match therapeutic levels in serum of patients do not activate store-operated Ca2+ entry. Antihypertensive Ca2+ channel blockers at pharmacological concentrations either have no effect on store-operated channels, activate them indirectly through store depletion or inhibit the channels. Importantly, a meta-analysis of published clinical trials and a prospective real-world analysis of patients prescribed single antihypertensive agents for 6 mo and followed up 1 yr later both show that dihydropyridines are not associated with increased heart failure or other cardiovascular disorders. Removal of dihydropyridines for treatment of hypertension cannot therefore be recommended.