Miracle-dz/UniFAR-FTUs huggingface dataset:
Transformative Potential of Agricultural Mobile Market Information System in Tamilnadu, India: An Exploratory Study

The agricultural sector is the largest and most critical economic sector and a developing country like India, with its economic backbone as agriculture, is highly dependent to sustain its population. To compete with other agricultural economies, a need exists to create effective linkage between the seat of agricultural production and market forces involved in the provision of goods to the consumers within India. A strong network communication must be established between the various stakeholders of agricultural trade to facilitate a balance between demand and supply. With the advent of mobile phones, internet, and other Information and Communication Technologies, new possibilities and multi-dimensional factors that create instant communication between the target groups have emerged and these ICT tools could be used as a source of agricultural information dissemination to the farmers. This paper analyses mobile based agricultural Market Information Services (MIS) that deliver critical market price information to farmers in Tamilnadu, India. The study also provides an overview of the ICT based mobile market linkage systems and analyses the operability of such projects. The study also assesses the benefits of such projects in providing relevant information to the farmers and the emerging opportunities for rural farmers to make constructive use of the e-agriculture projects.
Validation of a cataplexy questionnaire in 983 sleep-disorders patients.

Our goal was to validate a self-administered narcolepsy questionnaire focusing on cataplexy. Nine hundred and eight three consecutive subjects entering the Stanford Sleep Disorder Clinic completed the questionnaire. Clinic physicians reported on the presence or absence of "clear-cut" cataplexy. Responses to 51 cataplexy-related questionnaire items were compared between subjects with clear-cut cataplexy (n = 63) and all other patients (n = 920). As previously reported, a large portion of the non-narcoleptic population was found to experience muscle weakness with various intense emotions (1.8% to 18.0%) or athletic activities (26.2% to 28.8%). Factor analysis and Receiver Operating Characteristic Curve (ROC) analysis were used to determine the most predictive items for clear-cut cataplexy. Most strikingly, cataplexy was best differentiated from other types of muscle weakness when triggered by only three typical situations: "when hearing and telling a joke," "while laughing," or "when angry. " Face or neck, rather than limbs, were also more specifically involved in clear-cut cataplexy. Other items, such as length of attacks, bilaterality, and alteration in consciousness, were poorly predictive. A simple decision tree was constructed to isolate high-(91.7%) and low-(0.6%) risk groups for cataplexy. This questionnaire will be used to increase diagnostic consistency across clinical centers, thus providing more homogenous subject pools for clinical and basic research studies.
Insular neural system controls decision-making in healthy and methamphetamine-treated rats

Significance Patients with addiction have a greater tendency to engage in risk-taking behavior. However, the neural substrates responsible for these deficits remain unknown. Here we demonstrated that chronic methamphetamine-treated rats preferred high-risk/high-reward actions and assigned higher value to high returns, indicative of altered decision-making. Pharmacological studies revealed that the insular neural system controls decision-making in both healthy and methamphetamine-treated rats. We further confirmed the role of the insular cortex in decision-making using designer receptor exclusively activated by designer drug technology. Because decision-making is a cognitive process that influences many aspects of daily living and both mental and physical health, the findings of this study have broader implications. Patients suffering from neuropsychiatric disorders such as substance-related and addictive disorders exhibit altered decision-making patterns, which may be associated with their behavioral abnormalities. However, the neuronal mechanisms underlying such impairments are largely unknown. Using a gambling test, we demonstrated that methamphetamine (METH)-treated rats chose a high-risk/high-reward option more frequently and assigned higher value to high returns than control rats, suggestive of changes in decision-making choice strategy. Immunohistochemical analysis following the gambling test revealed aberrant activation of the insular cortex (INS) and nucleus accumbens in METH-treated animals. Pharmacological studies, together with in vivo microdialysis, showed that the insular neural system played a crucial role in decision-making. Moreover, manipulation of INS activation using designer receptor exclusively activated by designer drug technology resulted in alterations to decision-making. Our findings suggest that the INS is a critical region involved in decision-making and that insular neural dysfunction results in risk-taking behaviors associated with altered decision-making.
Antiepileptic drugs in women with epilepsy during pregnancy

Prescribing antiepileptic drugs (AEDs) in pregnancy is a challenge to the clinician. A multitude of questions arise that must be addressed even prior to conception. In women with proven epilepsy, it may be dangerous to stop or even change the AED regimen during pregnancy. Changes could lead to injury or death in both the mother and the fetus. In the rare cases when discontinuing an AED is plausible, it should be done methodically in consultation with the physician prior to conception. Most women with epilepsy are consigned to continue their AEDs before, during and after pregnancy. The metabolism of AEDs may change drastically during pregnancy. These changes must be addressed by the clinician. Drug levels should be monitored consistently during pregnancy. The risks to the fetus must be delineated in terms of side effects from specific drugs as well as risks from the seizure disorder itself. Many AEDs have well known teratogenic effects, and these must be elucidated to the mother. There are risks (theoretical and evidence based) for obstetrical complications, poor neonatal outcomes, congenital malformations and even cognitive effects on the child later in life. These risks are addressed in this article with respect to individual AEDs. Recommendations include but are not limited to preconception counseling, taking folate pre and post conception, prescribing the most effective AED while minimizing risks, and avoiding polytherapy and valproate if possible.
On Sampling from the Gibbs Distribution with Random Maximum A-Posteriori Perturbations

In this paper we describe how MAP inference can be used to sample efficiently from Gibbs distributions. Specifically, we provide means for drawing either approximate or unbiased samples from Gibbs' distributions by introducing low dimensional perturbations and solving the corresponding MAP assignments. Our approach also leads to new ways to derive lower bounds on partition functions. We demonstrate empirically that our method excels in the typical "high signal -high coupling" regime. The setting results in ragged energy landscapes that are challenging for alternative approaches to sampling and/or lower bounds.
An assessment of wheat yield sensitivity and breeding gains in hot environments

Genetic improvements in heat tolerance of wheat provide a potential adaptation response to long-term warming trends, and may also boost yields in wheat-growing areas already subject to heat stress. Yet there have been few assessments of recent progress in breeding wheat for hot environments. Here, data from 25 years of wheat trials in 76 countries from the International Maize and Wheat Improvement Center (CIMMYT) are used to empirically model the response of wheat to environmental variation and assess the genetic gains over time in different environments and for different breeding strategies. Wheat yields exhibited the most sensitivity to warming during the grain-filling stage, typically the hottest part of the season. Sites with high vapour pressure deficit (VPD) exhibited a less negative response to temperatures during this period, probably associated with increased transpirational cooling. Genetic improvements were assessed by using the empirical model to correct observed yield growth for changes in environmental conditions and management over time. These ‘climate-corrected’ yield trends showed that most of the genetic gains in the high-yield-potential Elite Spring Wheat Yield Trial (ESWYT) were made at cooler temperatures, close to the physiological optimum, with no evidence for genetic gains at the hottest temperatures. In contrast, the Semi-Arid Wheat Yield Trial (SAWYT), a lower-yielding nursery targeted at maintaining yields under stressed conditions, showed the strongest genetic gains at the hottest temperatures. These results imply that targeted breeding efforts help us to ensure progress in building heat tolerance, and that intensified (and possibly new) approaches are needed to improve the yield potential of wheat in hot environments in order to maintain global food security in a warmer climate.
Oligopole et différenciation des produits : une contribution à l'étude de la concurrence imparfaite

La these est constituee de deux parties. Dans la premiere partie, nous etablissons un lien entre trois types differents d'approche utilises pour decrire la demande pour des biens differencies. La premiere approche est celle des modeles de choix discrets a utilite stochastique. La seconde approche est celle du consommateur representatif. En particulier nous etablissons aussi un lien entre le modele "CES" et les modeles de choix discret. La troisieme approche correspond a la representation dans l'espace des caracteristiques (a la Lancaster). La seconde partie de la these propose l'utilisation des modeles de choix discret dans le cadre de l'etude de la concurrence oligopolistique. Nous analysons d'abord la concurrence en qualite et en prix. Nous analysons ensuite la concurrence en localisation et en prix dans le cadre du modele d'hotelling. Nous montrons que les questions de non-existence peuvent etre resolues lorsque les biens sont suffisamment differencies et nous comparons differentes politiques spatiales.
Restricted CD4+ T cell receptor repertoire impairs cognitive function via alteration of Th2 cytokine levels

ABSTRACT Despite the effects of CD4+ T cell dysfunction on cognitive and behavioral impairment are well established, the effects of Th2 cytokines on the adult hippocampal neurogenesis and cognitive function in restricted CD4+ T cell receptor (TCR) repertoire model have not been fully elucidate. We found that mice with restricted CD4+ repertoire TCR showed decreased adult hippocampal neurogenesis using OT-II mice. Moreover, we demonstrated that OT-II mice showed increased Th2 cytokine levels in peripheral organs and IL-4 levels in brain. Taken together, altered Th2 cytokine levels may impact learning and memory via impaired adult neurogenesis in restricted CD4+ repertoire TCR mice.
Playing the Gender Card: The Uses and Abuses of Gender in Australian Politics

Former Australian Labor Prime Minister Julia Gillard was accused of unfairly playing the gender card against then Opposition Leader Tony Abbott in her accusations of sexism and misogyny. It was also claimed that she had thereby initiated the first “gender war” in Australian politics. Analyzing Australian politicians’ discursive mobilizations of gender during the Gillard period provides useful insights that are relevant to the broader international literature on gender and politics, particularly given that Gillard's experiences have similarities with those of prominent female politicians in other countries, including Hillary Clinton. The article argues for a much broader understanding of playing the gender card that includes both issues of femininity and masculinity and that also emphasizes the close relationship between issues of playing the gender card and issues of gender performativity.
High-order hybridizable discontinuous Galerkin formulation for two-phase flow simulation

Nowadays, numerical simulation of oil reservoirs plays a major role in petroleum engineering. During the initial stages of hydrocarbon production (primary recovery), the pressure difference between the reservoir and the separator at the surface is high enough to move the hydrocarbons. Afterwards, as the pressure of the reservoir decreases, a fluid (usually water) is injected to maintain the flow rate. This is known as secondary recovery. If a single hydrocarbon is considered and the pressure is above its bubble point pressure, the two-phase immiscible flow model is widely used in industry.
Capnographic monitoring of propofol-based sedation during colonoscopy

Background and study aims: Capnography enables the measurement of end-tidal CO2 and thereby the early detection of apnea, prompting immediate intervention to restore ventilation. Studies have shown that capnographic monitoring is associated with a reduction of hypoxemia during sedation for endoscopy and early detection of apnea during sedation for colonoscopy. The primary aim of this prospective randomized study was to evaluate whether capnographic monitoring without tracheal intubation reduces hypoxemia during propofol-based sedation in patients undergoing colonoscopy. Patients and methods: A total of 533 patients presenting for colonoscopy at two study sites were randomized to either standard monitoring (n = 266) or to standard monitoring with capnography (n = 267). The incidence of hypoxemia (SO2 < 90 %) and severe hypoxemia (SO2 < 85 %) were compared between the groups. Furthermore, risk factors for hypoxemia were evaluated, and sedation performed by anesthesiologists was compared with nurse-administered propofol sedation (NAPS) or endoscopist-directed sedation (EDS). Results: The incidence of hypoxemia was significantly lower in patients with capnography monitoring compared with those receiving standard monitoring (18 % vs. 32 %; P = 0.00091). Independent risk factors for hypoxemia were age (P = 0.00015), high body mass index (P = 0.0044), history of sleep apnea (P = 0.025), standard monitoring group (P = 0.000069), total dose of propofol (P = 0.031), and dose of ketamine (P < 0.000001). Patients receiving anesthesiologist-administered sedation developed hypoxemic events more often than those receiving NAPS or EDS. In patients with anesthesiologist-administered sedation, sedation was deeper, a combination of sedative medication (propofol, midazolam and/or ketamine) was administered significantly more often, and sedative doses were significantly higher compared with patients receiving NAPS or EDS. Conclusions: In patients undergoing colonoscopy during propofol-based sedation capnography monitoring with a simple and inexpensive device reduced the incidence of hypoxemia.
Neuropeptides regulating Drosophila behavior

List of contributors 1. The anatomical organization of the compound eye's visual system Ian A. Meinertzhagen 2. Neuropeptides regulating Drosophila behavior Dick R. Nassel 3. Vision Nina Vogt and Claude Desplan 4. Sensory coding of olfaction and taste Christi A. Scott and Anupama Dahanukar 5. Nociception Ken Honjo, Jessica Robertson and W. Daniel Tracey, Jr 6. Flight behavior: degradation of flight muscle power and locomotor capacity in transgenic Drosophila Fritz-Olaf Lehmann 7. Behavioral genetics of Drosophila female postmating responses C. Dustin Rubinstein, Brigitte Dauwalder and Mariana F. Wolfner 8. Circadian rhythms Nara I. Muraro and M. Fernanda Ceriani 9. Courtship learning Leslie C. Griffith 10. Place memory Daniela Ostrowski and Troy Zars 11. Neurodegeneration models in Drosophila Bidisha Roy and George R. Jackson 12. Drosophila model of cognitive disorders: focus on memory abnormality Lisha Shao and Yi Zhonga 13. Age-related memory impairment in Drosophila Minoru Saitoe, Shinjiro Saeki, Yukinori Hirano and Junjiro Horiuchi 14. Functional analysis of natural clock gene variation Charalambos P. Kyriacou 15. Natural variation in foraging behaviour Bryon N. Hughson, Viet Pham and Marla B. Sokolowski 16. Using neuron-specific RNAi in Drosophila for understanding the molecular and neuronal basis of behavior Ricardo Leitao-Goncalves and Carlos Ribeiro 17. Systems genetics of behavior in Drosophila Robert R. H. Anholt, Trudy F. C. Mackay and Eric A. Stone 18. Olfactory learning and memory assays Christopher J. Tabone and J. Steven de Belle 19. Intersectional strategies for cell type specific expression and transsynaptic labeling Taylor R. Fore and Bing Zhang 20. Imaging Drosophila brain neurons for 'FlyCircuit' analysis Chih-Yung Lin and Ann-Shyn Chiang References Index.
Angiotensin II Suppression in Humans by the Orally Active Renin Inhibitor Aliskiren (SPP100): Comparison With Enalapril

Renin is the main determinant of angiotensin (Ang) II levels. It, therefore, always appeared desirable to reduce Ang II levels by direct inhibition of renin. So far, specific renin inhibitors lacked potency and/or oral availability. We tested the new orally active nonpeptidic renin inhibitor SPP100 (Aliskiren, an octanamide with a 50% inhibitory concentration [IC50] in the low nanomolar range) in 18 healthy volunteers on a constant 100 mmol/d sodium diet using a double-blind, 3-way crossover protocol. In 3 periods of 8 days, separated by wash-outs of 6 days, each volunteer received 2 dosage levels of Aliskiren (low before high; 40 and 80 or 160 and 640 mg/d) and randomized placebo or 20 mg enalapril. Aliskiren was well tolerated. Not surprisingly, blood pressure and heart rate remained unchanged in these normotensive subjects. There was a dose-dependent decrease in plasma renin activity, Ang I, and Ang II following single doses of Aliskiren starting with 40 mg. Inhibition was still marked and significant after repeated dosing with maximal decreases in Ang II levels by 89% and 75% on Days 1 and 8, respectively, when the highest dose of Aliskiren was compared with placebo. At the same time, mean plasma active renin was increased 16- and 34-fold at the highest dose of Aliskiren. Plasma drug levels of Aliskiren were dose-dependent with maximal concentrations reached between 3 to 6 hours after administration; steady state was reached between 5 and 8 days after multiple dosing. Less than 1% of dose was excreted in the urine. Plasma and urinary aldosterone levels were decreased after doses of Aliskiren ≥80 mg and after enalapril. Aliskiren at 160 and 640 mg enhanced natriuresis on Day 1 by +45% and +62%, respectively, compared with placebo (100%, ie, 87±11 mmol/24h) and enalapril (+54%); kaliuresis remained unchanged. In conclusion, the renin inhibitor Aliskiren dose-dependently decreases Ang II levels in humans following oral administration. The effect is long-lasting and, at a dose of 160 mg, is equivalent to that of 20 mg enalapril. Aliskiren has the potential to become the first orally active renin inhibitor that provides a true alternative to ACE-inhibitors and Ang II receptor antagonists in therapy for hypertension and other cardiovascular and renal diseases.
Pharmacogenetics, Plasma Concentrations, Clinical Signs and EEG During Propofol Treatment

A variety of techniques have been developed to monitor the depth of anaesthesia. Propofol's pharmacokinetics and response vary greatly, which might be explained by genetic polymorphisms. We investigated the impact of genetic variations on dosage, anaesthetic depth and recovery after total intravenous anaesthesia with propofol. A total of 101 patients were enrolled in the study. The plasma concentration of propofol during anaesthesia was measured using high‐performance liquid chromatography. EEG was monitored during the surgical procedure as a measure of anaesthetic depth. Pyrosequencing was used to determine genetic polymorphisms in CYP2B6, CYP2C9, the UGTIA9‐promotor and the GABRE gene. The correlation between genotype and to plasma concentration at the time of loss of consciousness (LOC), the total induction dose, the time to anaesthesia, eye opening and clearance were investigated. EEG monitoring showed that the majority of the patients had not reached a sufficient level of anaesthetic depth (subdelta) at the time of loss of consciousness despite a high induction dose of propofol. Patients with UGT1A9‐331C/T had a higher propofol clearance than those without (p = 0.03) and required a higher induction dose (p = 0.03). The patients with UGT1A9‐1818T/C required a longer time to LOC (p = 0.03). The patients with CYP2C9*2 had a higher concentration of propofol at the time of LOC (p = 0.02). The polymorphisms in the metabolizing enzymes and the receptor could not explain the large variation seen in the pharmacokinetics of propofol and the clinical response seen. At LOC, the patients showed a large difference in EEG pattern.
Age-related Eye Diseases: An Emerging Challenge for Public Health Professionals

In April 2004, The Eye Disease Prevalence Research Group published a series of articles that included age-specific estimates for the prevalence of low vision and blindness in whites, African Americans, and Hispanics living in the United States. Also included were age-, sex-, and ethnic-specific incidences of the following age-related eye diseases: diabetic retinopathy, macular degeneration, cataracts, and glaucoma. We reviewed the group's series of articles and highlighted key findings on the overall prevalence of and risk factors for age-related eye diseases, as well as opportunities to preserve and restore vision. We examined publications that show the public health impact of age-related eye diseases and the importance of projected increases in prevalence of low vision and blindness. Approximately 1 in 28 Americans aged older than 40 years is affected by low vision or blindness. Among community-dwelling adults, the prevalence of low vision and blindness increases dramatically with age in all racial and ethnic groups. Whites have higher rates of macular degeneration than African Americans, but glaucoma is more common among older African Americans. Between 2000 and 2020, the prevalence of blindness is expected to double. Age-related eye diseases are costly to treat, threaten the ability of older adults to live independently, and increase the risk for accidents and falls. To prevent vision loss and support rehabilitative services for people with low vision, it is imperative for the public health community to address the issue through surveillance, public education, and coordination of screening, examination, and treatment.