Miracle-dz/UniFAR-FTUs huggingface dataset:
COPING WITH DIFFICULT SITUATIONS AND LOAD IN MANAGEMENT

The study is based on specific personal characteristics of managers, for instance, a relatively good choice of behavioural strategy and some practical studies as well as on phases of coping with difficult situations, appropriate and inappropriate ways of coping, coping styles focused on task, emotions and avoidance. Coping with difficult and stressful situations is today a broadly discussed topic among people from the professional public. The present study introduces our own research, experimental evaluation of working hypothesis, evaluation of research data and presentation of results. The aim is to analyse the relations between personal characteristics of managers and the use of coping strategies in difficult situations in management. The study also focuses on significant differences in the choice of selected coping strategies in connection with the basic socio-demographic characteristics of managers – sex and age. The results presented confirmed our assumption that statistically there are significant relations between sex and selected coping strategies in management. From the methodological point of view the research is based on the preparation and verification of original methods of the above mentioned topics. Each of the interviewed managers represented, in their own way, originality and provided our research original and unique results which are processed, evaluated and presented in tables and graphs. DOI: http://dx.doi. org/10.5755/j01.em. 19.2. 7247
Relocating for Retirement Or what makes for a happy retirement

This paper reports the preliminary results of a study undertaken to consider the decision-making processes of retirees who have recently located to retirement villages within the Adelaide Metropolitan District. The study recognises that the South Australia population is aging faster than any other state in Australia and suggests that the decision making of retirees both pensioned and self funded are of key interest to those in the areas of housing provision, housing investment and welfare provision. There have been a number of studies undertaken in the US (Marans 1983, Golant 1987, Stimson, 1990) where the environment of retirement villages, the health and "fit" of movers and the push and pull factors relating to relocation decisions have been recognised. However little has been documented about the housing decision process of retirees in Australia and there have been few studies into the location choices of households who have relocated to retirement villages. This study complements ARC funded research currently being undertaken in Queensland by the Australian Housing and Urban Research Institute which has been restricted to the Brisbane region.
The Changing Australian City: New Patterns, New Policies and New Research Needs1

Introduction: The Underlying Drivers of Metropolitan Change With few exceptions Australian cities are experiencing a range of intensifying pressures for change at the present time. Sydney, Melbourne, Brisbane, Canberra and Perth are all growing at substantial rates of increase. Darwin has its own set of pressures that mark it out from the rest. Adelaide and Hobart may be dealing with the rather different issues of lower growth. At the same time all these cities have markedly differing sub-regions and areas within them that are performing in a variety of ways. The pressures that are impacting on Australian cities at the present time, include, in no particular order:
Household types as a tool to understand adaptive capacity: case studies from Cambodia, Lao PDR, Bangladesh and India

Supporting smallholder households to adapt to climate variability is a high priority for development agencies and national governments. Efforts to support climate adaptation in developing countries occur within highly dynamic contexts. Macro-level changes in national and regional economies manifest in dynamic local conditions, such as migration, changing household labour dynamics, market access and land-use options. Research aimed at developing adaptation options is often focused on particular activities or industries and struggles to take into account the broader, interrelated suite of household livelihood activities or the non-climate stressors driving change and adaptation. This paper explores the use of household types to (a) understand the diversity of household circumstances and (b) place agricultural adaptation options within the broader context of household livelihoods. Results from application in four countries are discussed, which highlight the utility of the method and identify broader level trends and drivers that are common challenges (experienced differently) across multiple contexts.
bZIP28 and NF-Y Transcription Factors Are Activated by ER Stress and Assemble into a Transcriptional Complex to Regulate Stress Response Genes in Arabidopsis[W][OA]

This work provides evidence that both bZIP28 and NF-Y subunits are recruited under stress to form a transcriptional complex that upregulates the expression of endoplasmic reticulum stress-induced genes. The bZIP28/NF-Y complex specifically binds to an element common to the promoters of the targeted stress genes. Stress agents known to elicit the unfolded protein response in Arabidopsis thaliana upregulate the expression of a constellation of genes dependent on the membrane-associated basic domain/leucine zipper (bZIP) transcription factor, bZIP28. Among the stress-activated genes, a consensus promoter sequence corresponding to the endoplasmic reticulum (ER) stress-responsive element I (ERSE-I), CCAAT-N10-CACG, was identified. Disruption of either the CCAAT or CACG subelement in ERSE-I resulted in reduction of the transcriptional response to ER stress. bZIP28 forms homo- and heterodimers with other bZIP TF family members (in subgroup D) and interacts with CCAAT box binding factors, heterotrimeric factors composed of NF-Y subunits. Arabidopsis encodes 36 NF-Y subunits, and it was found that subunits NF-YB3 and -YC2 interact with bZIP28 and NF-YA4, respectively, in a yeast three-hybrid system. A transcriptional complex containing bZIP28 and the above-mentioned three NF-Y subunits was assembled in vitro on DNA containing ERSE-I. bZIP28, on its own, binds to the CACG subelement in ERSE-I to form a smaller complex I, and in combination with the NF-Y subunits above, bZIP28 assembles into a larger transcriptional complex (complex II). bZIP28 was shown to interact with NF-Y subunits in vivo in bimolecular fluorescence complementation analyses and in coimmunoprecipitation assays. Treatment of seedlings with ER stress agents led to the upregulation of NF-YC2 and the relocation of NF-YB3 from the cytoplasm to the nucleus. Thus, in response to ER stress, bZIP28 is mobilized by proteolysis and recruits NF-Y subunits to form a transcriptional complex that upregulates the expression of ER stress-induced genes.
Identification of GRO1 as a Critical Determinant for Mutant p53 Gain of Function*

Mutant p53 gain of function contributes to cancer progression, increased invasion and metastasis potentials, and resistance to anticancer therapy. The ability of mutant p53 to acquire its gain of function is shown to correlate with increased expression of progrowth genes, such as c-MYC, MDR1, and NF-κB2. However, most of the published studies to identify mutant p53 target genes were performed in a cell system that artificially overexpresses mutant p53. Thus, it remains unclear whether such mutant p53 targets can be regulated by endogenous physiological levels of mutant p53. Here, we utilized SW480 and MIA-PaCa-2 cells, in which endogenous mutant p53 can be inducibly knocked down, to identify mutant p53 target genes that potentially mediate mutant p53 gain of function. We found that knockdown of mutant p53 inhibits GRO1 expression, whereas ectopic expression of mutant R175H in p53-null HCT116 cells increases GRO1 expression. In addition, we found that endogenous mutant p53 is capable of binding to and activating the GRO1 promoter. Interestingly, ectopic expression of GRO1 can rescue the proliferative defect in SW480 and MIA-PaCa-2 cells induced by knockdown of mutant p53. Conversely, knockdown of endogenous GRO1 inhibits cell proliferation and thus abrogates mutant p53 gain of function in SW480 cells. Taken together, our findings define a novel mechanism by which mutant p53 acquires its gain of function via transactivating the GRO1 gene in cancer cells. Thus, targeting GRO1 for cancer therapy would be applicable to a large portion of human tumors with mutant p53, but the exploration of GRO1 as a potential target should take the mutation status of p53 into consideration.
Formal and Informal Technology Transfer from Academia to Industry: Complementarity Effects and Innovation Performance

Literature has identified formal and informal channels in university technology transfer. While formal technology transfer typically involves a legal contract on a patent or on collaborative research activities, informal transfer channels refer to personal contacts and hence to the tacit dimension of knowledge transfer. Research is, however, scarce regarding the interaction of formal and informal transfer mechanisms. In this paper, we analyze whether these activities are mutually reinforcing, i.e. complementary. Our analysis is based on a comprehensive dataset of more than 2,000 German manufacturing firms. We perform direct and indirect tests for the complementarity of formal and informal technology transfer. Our results confirm a complementary relationship: using both transfer channels contributes to higher innovation performance. The management of the firm should therefore strive to maintain close informal relationships with universities to realize the full potential of formal technology transfer.
Adaptive designs for comparative effectiveness research trials

Abstract Medical and health policy decision-makers require improved design and analysis methods for comparative effectiveness research (CER) trials. In CER trials, there may be limited information to guide initial design choices. In general settings, adaptive designs (ADs) have effectively overcome limits on initial information. However, CER trials have fundamental differences from standard clinical trials including population heterogeneity and a vaguer concept of a “minimum clinically meaningful difference”. The objective of this article is to explore the use of a particular form of ADs for comparing treatments within the CER trial context. To achieve this, the authors review the current state of clinical CER. They also identify areas of CER as particularly strong candidates for application of novel AD and illustrate the potential usefulness of the designs and methods for two group comparisons. The authors found that ADs can stabilize power. Furthermore, the designs ensure adequate power for true effects are at least at clinically significant pre-planned effect size, or when variability is larger than expected. The designs allow for sample size savings when the true effect is larger or when variability is smaller than planned. The authors conclude that ADs in CER have great potential to allow trials to successfully and efficiently make important comparisons.
Akt Activation Emulates Chk1 Inhibition and Bcl2 Overexpression and Abrogates G2 Cell Cycle Checkpoint by Inhibiting BRCA1 Foci*

Akt is perhaps the most frequently activated oncoprotein in human cancers. Overriding cell cycle checkpoint in combination with the inhibition of apoptosis are two principal requirements for predisposition to cancer. Here we show that the activation of Akt is sufficient to promote these two principal processes, by inhibiting Chk1 activation with concomitant inhibition of apoptosis. These activities of Akt cannot be recapitulated by the knockdown of Chk1 alone or by overexpression of Bcl2. Rather the combination of Chk1 knockdown and Bcl2 overexpression is required to recapitulate Akt activities. Akt was shown to directly phosphorylate Chk1. However, we found that Chk1 mutants in the Akt phosphorylation sites behave like wild-type Chk1 in mediating G2 arrest, suggesting that the phosphorylation of Chk1 by Akt is either dispensable for Chk1 activity or insufficient by itself to exert an effect on Chk1 activity. Here we report a new mechanism by which Akt affects G2 cell cycle arrest. We show that Akt inhibits BRCA1 function that induces G2 cell cycle arrest. Akt prevents the translocation of BRCA1 to DNA damage foci and, thereby, inhibiting the activation of Chk1 following DNA damage.
Generation of free fatty acids from phospholipids regulates stratum corneum acidification and integrity.

There is evidence that the "acid mantle" of the stratum corneum is important for both permeability barrier formation and cutaneous antimicrobial defense. The origin of the acidic pH of the stratum corneum remains conjectural, however. Both passive (e.g., eccrine/sebaceous secretions, proteolytic) and active (e.g., proton pumps) mechanisms have been proposed. We assessed here whether the free fatty acid pool, which is derived from phospholipase-mediated hydrolysis of phospholipids during cornification, contributes to stratum corneum acidification and function. Topical applications of two chemically unrelated secretory phospholipase sPLA2 inhibitors, bromphenacylbromide and 1-hexadecyl-3-trifluoroethylglycero-sn-2-phosphomethanol, for 3 d produced an increase in the pH of murine skin surface that was paralleled not only by a permeability barrier abnormality but also altered stratum corneum integrity (number of strippings required to break the barrier) and decreased stratum corneum cohesion (protein weight removed per stripping). Not only stratum corneum pH but also all of the functional abnormalities normalized when either palmitic, stearic, or linoleic acids were coapplied with the inhibitors. Moreover, exposure of intact murine stratum corneum to a neutral pH for as little as 3 h produced comparable abnormalities in stratum corneum integrity and cohesion, and further amplified the inhibitor-induced functional alterations. Furthermore, short-term applications of an acidic pH buffer to inhibitor-treated skin also reversed the abnormalities in stratum corneum integrity and cohesion, despite the ongoing decrease in free fatty acid levels. Finally, the secretory-phospholipase-inhibitor-induced alterations in integrity/cohesion were in accordance with premature dissolution of desmosomes, demonstrated both by electron microscopy and by reduced desmoglein 1 levels in the stratum corneum (shown by immunofluorescence staining and visualized by confocal microscopy). Together, these results demonstrate: (i) the importance of phospholipid-to-free-fatty-acid processing for normal stratum corneum acidification; and (ii) the potentially important role of this pathway not only for barrier homeostasis but also for the dual functions of stratum corneum integrity and cohesion.
Privatisation and Cultural Change: A Case Study of Management Development in British Telecom

The privatisation and reorganisation of British Telecom (BT) presented its various divisions with the problem of transferring commercial awareness at the top management level to middle management level. A management development programme was designed which combined computer‐based business strategy modelling and “best practice” modelling in human relations. These areas were previously treated separately. The greatest problem for senior managers was modifying their values. For middle managers the problem was that their values were overturned and themselves threatened. The one‐week courses allowed fears and confusions to be aired and examined. By exposing managers to “best practice” procedures they were given frameworks to help them determine how to forge a relationship between a sensible economic strategy and a complementary culture. The programme has been very successful and is to be implemented in other BT businesses.
Lower Bounds for non-Boolean Constraint Satisfaction

We use a recent recycling construction of Samorodnitsky and Trevisan combined with the techniques of H(cid:23)astad to show that the k - CSP problem over an Abelian group G cannot be approximated within j G j k − O ( p k ) − (cid:15) , for any constant (cid:15) > 0, unless P = NP . This lower bound matches well with the best known upper bound, j G j k − 1 , of Serna, Trevisan and Xhafa.
Citizens, Politics and Social Communication: Information and Influence in an Election Campaign

Acknowledgments Part I. Democratic Politics and Social Communication: 1. The multiple levels of democratic politics 2. A research strategy for studying electoral politics Part II. Electoral Dynamics and Social Communication: 3. The social dynamics of political preference 4. Durability, volatility and social influence 5. Social dynamics in an election campaign Part III. Networks, Political Discussants, and Social Communication: 6. Political discussion in an election campaign 7. Networks in context: The social flow of political information 8. Choice, social structure, and the informational coercion of minorities 9. Discussant effects on vote choice: Intimacy, structure, and interdependence 10. Gender effects on political discussion: The political networks of men and women Part IV. The Organizational Locus of Social Communication: 11. One-party politics and the voter revisited: strategic and behavioral bases of partisanship 12. Political parties and electoral mobilization: political structure, social structure, and the party canvass 13. Alternative contexts of political preference 14. Political consequences of interdependent citizens Bibliography Index.
TEACHING SUPPLY CHAIN MANAGEMENT TO BUSINESS EXECUTIVES

By focusing on the management of entire value chains, supply chain management has gained increasing popularity in management research and in the teaching of global businesses. The right practices can take companies to great heights; lack of attention can draw companies close to peril. In teaching supply chain management to business executives, there are four major issues that need to be highlighted: flawless execution of operations, the change from supply to demand focus, outsourcing and supply base development, and partnership implementation. This article explains these four issues, and the material that is developed at IMD to teach each of them.
Celecoxib Induces Functional Recovery after Intracerebral Hemorrhage with Reduction of Brain Edema and Perihematomal Cell Death

The selective cyclooxygenase-2 (COX-2) inhibitor has been reported to have antiinflammatory, neuroprotective, and antioxidant effects in ischemia models. In this study, the authors examined whether a selective COX-2 inhibitor (celecoxib) reduces cerebral inflammation and edema after intracerebral hemorrhage (ICH), and whether functional recovery is sustained with longer treatment. ICH was induced using collagenase in adult rats. Celecoxib (10 or 20 mg/kg) was administered intraperitoneally 20 minutes, 6 hours, and 24 hours after ICH and then daily thereafter. Seventy-two hours after ICH induction, the rats were killed for histologic assessment and measurement of brain edema and prostaglandin E2. Behavioral tests were performed before and 1, 7, 14, 21, and 28 days after ICH. The brain water content of celecoxib-treated rats decreased both in lesioned and nonlesioned hemispheres in a dose-dependent manner. Compared with the ICH-only group, the number of TUNEL-positive, myeloperoxidase-positive, or OX42-positive cells was decreased in the periphery of hematoma and brain prostaglandin E2 level was reduced in the celecoxib-treated group. Celecoxib-treated rats recovered better by the behavioral tests at 7 days after ICH throughout the 28-day period, and the earlier the drug was administered, the better the functional recovery. Evidence of similar effects in an autologous blood–injected model showed that direct collagenase toxicity was not the major cause of inflammation or cell death. These data suggest that celecoxib treatment after ICH reduces prostaglandin E2 production, brain edema, inflammation, and perihematomal cell death in the perihematomal zone and induces better functional recovery.
Progress on information and communication technologies in hospitality and tourism

Purpose – The purpose of this paper is to establish the progress of information and communication technology (ICT) based on a review of papers published in tourism and hospitality journals between 2009 and 2013. Design/methodology/approach – Based on three major databases, 107 journal papers were retrieved and reviewed. The papers were grouped into two major categories, consumer and supplier, which generally comprise the key players in the industries. Findings – A content analysis showed that hospitality and tourism industries use ICT in different functional units and for different applications. This, in turn, indicates their wide adoption in the industry. Industrial implications are discussed. Practical implications – On the basis of the content analysis, industry practitioners can learn about up-to-date practices and decide how to take advantage of recent technological developments. Originality/value – A major contribution of this paper is the comprehensive review of recently published papers in tourism and hospitality journals from the perspectives of consumer and supplier.
The trade distorting effects of export refunds: The case of beef exports to Africa

Abstract The usual sale of European agricultural products to Africa using export refunds has been heavily discussed in recent decades. At the centre of the discussion are the consequences on the agricultural producers in Western and Southern Africa. There are two different points of view: On the one hand, the European Union's (EU) export policy reduces the prices on these markets and relieves high burdens on local producers; on the other hand are claims that refunds do not influence local prices significantly. Hence, the Common Agricultural Policy (CAP) has no effect on markets of third countries, besides depressing world market prices. This paper focuses on the effects of EU's export subsidies for beef exports on its market share in several developing countries. Twenty-seven African countries were analysed using a fixed-effects model between 1988 and 2000. The results clearly show a highly significant positive impact of the export refund rate on the market and the import share. With its export policy, the EU raises its market position and edges out other competitors.
Can Hormone “Resistant” Breast Cancer Cells Be Inappropriately Stimulated by Tamoxifen? a

We propose that the molecular heterogeneity of ER in breast tumor cells characterized by the presence of mutant receptor forms generates the cellular heterogeneity evident when PR or DNA ploidy are analyzed in cell subpopulations. Furthermore, it is likely that cellular heterogeneity leads to the lack of uniformity in response to tamoxifen that we have described. We find that heterogeneity of PR and DNA ploidy reflects existence of mixed subpopulations of breast cancer cells that are substantially remodeled under the influence of tamoxifen. It appears likely that rather than being "resistant," different subset of cells can be inhibited or stimulated by tamoxifen, and their suppression or outgrowth alters the phenotype of the tumor. PR heterogeneity of solid tumors of patients may predict for such a mixed, and potentially dangerous, response to antiestrogen treatment. As we learn more about the heterogeneity of PR, ER, and other proteins in tumors, we may be able to recognize such lethal subpopulations, which the FCM immunoassay can simply and rapidly measure. Our data also suggest that the use of tamoxifen as a chemopreventant in women at high risk of developing breast cancer should be viewed with caution.