Miracle-dz/UniFAR-FTUs huggingface dataset:
Trajectories of Maltreatment Re-Reports from Ages 4 to 12: Evidence for Persistent Risk after Early Exposure

This study identified trajectories of maltreatment re-reports between ages 4 and 12 for children first referred to Child Protective Services (CPS) prior to age 4 and either removed from the home or assessed by a CPS intake worker as moderately or highly likely to be abused/neglected in the future, absent intervention. Participants (n = 501) were children from the Southwest and Northwest sites of the Consortium for Longitudinal Studies of Child Abuse and Neglect (LONGSCAN). During the 8-year follow-up period, 67% of children were re-reported. Growth mixture modeling identified four trajectory classes: No re-report (33%), Continuous re-reports (10%), Intermittent re-reports (37%), and Early re-reports (20%). Membership in classes with relatively more re-reports was predicted by several factors assessed at age 4, including physical abuse; living with a biological/step-parent; caregiver alcohol abuse, depression, and lack of social support; receipt of Aid to Families with Dependent Children (AFDC); and number of children in the home. For a subpopulation of high-risk children first reported in early childhood, risk for maltreatment re-reporting may persist longer than previously documented, continuing 8 to 12 years after the first report. Studying children who experience repeated reports to Child Protective Services (CPS) for suspected maltreatment is important for several reasons. Re-reports may indicate that the system has failed to ensure a child’s safety (Fluke, Shusterman, Hollinshead, & Yuan, 2005), and can lead to multiple out-of-home placements, disrupting children’s relationships and increasing their
Analysis of Deep Complex-Valued Convolutional Neural Networks for MRI Reconstruction

Many real-world signal sources are complex-valued, having real and imaginary components. However, the vast majority of existing deep learning platforms and network architectures do not support the use of complex-valued data. MRI data is inherently complex-valued, so existing approaches discard the richer algebraic structure of the complex data. In this work, we investigate end-to-end complex-valued convolutional neural networks - specifically, for image reconstruction in lieu of two-channel real-valued networks. We apply this to magnetic resonance imaging reconstruction for the purpose of accelerating scan times and determine the performance of various promising complex-valued activation functions. We find that complex-valued CNNs with complex-valued convolutions provide superior reconstructions compared to real-valued convolutions with the same number of trainable parameters, over a variety of network architectures and datasets.
Coordinate reference system of nonstationary signals

Authors have worked out a nonstationary signal analysis method on an example of research of laser lines. This method disclosed relationship between signal approximation coefficients and geometry signal characterizations (for instance, energy center, moment of inertia). Examples, which is demonstrating an application of this method for exact coordinate determination problem in laser line at displacement compensation in laser imaging are present.
Evolution saisonnière des éléments minéraux nutritifs (P, N, Si) et de l'oxygène dissous dans le lac de Pareloup

Le controle exerce par les stocks de phosphore et de silice disponibles sur le cycle de developpement du phytoplancton dans le lac de Pareloup est mis en evidence par l'evolution comparee des concentrations de chlorophylle, de phosphore, de nitrate et de silice dans la zone pelagique de ce lac au cours de deux cycles annuels. La sedimentation des diatomees qui se developpent au printemps contribue pour une large part au transfert de P et de Si dans les sediments. Les flux d'elements relargues a partir des sediments (charge interne), evalues par des mesures en chambres benthiques, sont ponctuellement eleves mais interviennent probablement peu dans les bilans en comparaison des apports par les eaux pompees dans le reservoir de Bage. L'influence des apports de Bage apparait de facon particulierement nette lorsqu'on considere la demande hypolimnique en oxygene dissous. Les concentrations reelles de P total dans l'eau de Pareloup sont cependant bien inferieures a ce que laisseraient prevoir ces 1 apports, ce qui suggere une influence favorable qui reste a preciser de la gestion des eaux.
Marine resources in the Mesolithic and Neolithic at the Grotta dell'Uzzo (Sicily): Evidence from isotope analyses of marine shells

Oxygen isotopes in shell carbonate samples from the marine rocky-shore intertidal gastropod Monodonta turbinata (Born) are investigated in both modern analogue specimens and in archaeological specimens from the Grotta dell’Uzzo (Sicily). Variations in shell edge values of δ18O in living specimens collected monthly over two years are closely correlated with monthly seawater temperatures measured at the time of collection, showing that the species can be used for palaeoseasonality studies. Analyses of shell edge δ18O values in archaeological specimens, from Mesolithic through to early Neolithic phases at the Grotta dell’Uzzo, enabled the inference of various seasons of collection of shellfish and how such seasonality varies between the different phases of occupation. Interesting similarities and differences exist between the seasons of marine shellfish exploitation and the seasons inferred from the vertebrate zooarchaeological assemblages. A major inference drawn from the analyses and discussion is that the exploitation of all marine resources (fish and shellfish) increased in the later Mesolithic and early Neolithic periods.
Psychiatric Symptoms and Marfan : Part of the Syndrome or Incidental to it ?

168 Psychoneuroimmunology is a rapidly developing field that is settled between basic science and therapeutic applications. The objective of psychoneuroimmunology is the investigation of the reciprocal influences of the nervous system and the immune system with regard to the effects on behaviour and health. The field covers a broad spectrum of research ranging from the therapeutic conditioning of the human immune response to the perspectives in the development of immune-based therapeutic strategies in psychiatric disorders. Both studies of immune function and therapeutic attempts in psychiatric disorders have been performed for many decades and include the development of the fever therapy by the Nobel prize laureate Wagner von Jauregg, who studied over many years immune-stimulating therapies with mycobacterium tuberculosis, salmonella typhii and plasmodium malariae in major psychoses before concentrating on the malaria therapy of syphilis. The increasing role of psychoneuroimmunology in psychiatry is primarily due to the rapid development of more sophisticated biological techniques, from flow cytometry or blotting techniques to advances in cell cultures and animal modelling. These techniques have helped us to identify the presence of immune-system transmitters and modulators like cytokines, and facilitated our understanding of the highly sophisticated, dynamic interplay that occurs within the immune system and between the nervous system and the immune system. Those insights allow more differentiated scientific approaches to the functional interactions between the different components of the immune system such as monocytes, macrophages, T-and B-cells, cytokines etc. For psychiatric disorders, effects of immune components at the blood-brain barrier, microglial cells which derive from macrophages and their role in CNS infection, and astroglial cells, which also contribute to the immunological CNS-cytokine interplay, are of special interest. When it became apparent that genetic and environmental factors contribute to the pathogenesis of major psychoses, immunogenetics and the role of infection came into the focus of psycho-immunological research. In the context of psychoneuroimmunological investigations it has been discussed that candidate genes for functional abnormalities might be inherited in genes of the immune system. The highly complex HLA-system has been studied in psychiatric disorders since the 1970s, but molecular genetic methods have recently allowed more valid studies of the HLA-system. The results of these investigations in major psychosis have not been convincing to date, although linkage studies point to the short arm of the chromosome 6 as a candidate region – the region where the HLA system is located. Moreover, mutations in the genes of cytokines, chemokines …
The earthquake magnitude is influenced by previous seismicity

Seismic occurrence is characterized by clustering in space, time and magnitude. Correlations between magnitudes of subsequent events have been recently attributed to catalog incompleteness. Here we investigate the effect of catalog completeness on the amplitude of magnitude correlations. The analysis of two California regions with different levels of catalog accuracy and different lower magnitude thresholds indicate that the amplitude of correlations does not depend on catalog incompleteness. Conversely, correlations are controlled by the probability that two events belong to the same mainshock‐aftershock sequence. Numerical simulations of the ETAS model, where magnitude correlations are absent by construction, provide a counter‐test supporting our conclusions.
A review of Canadian remote sensing applications in hydrology, 1995–1999

The potential of remote sensing for providing information to hydrologists and water resources practitioners has been recognized since the 1970s. The variety of satellite and airborne platforms and the greater ease of access to imagery now make it possible to evaluate and quantify an increasingly large number of watershed physical characteristics and state variables. Canadian scientists have been very active over the last 5 years creating algorithms to extract hydrological information from remotely sensed data and to develop new, or adapt existing, hydrological methods capable of making efficient use of this new information. Over the years, research and applications of remote sensing in Canadian hydrology have embraced a variety of topics and recent research has placed significant emphasis on radar remote sensing as the Canadian RADARSAT satellite was launched successfully on 4 November 1995. This paper reviews recent (1995-99) remote sensing contributions in hydrology by Canadians, specifically focusing on the usefulness and applicability of current remote sensing technology for water management purposes. A very brief description of the theory underlying each application as well as relevant sensors is presented.
Exploring enablers and barriers toward COVID-19 vaccine acceptance among Arabs: A qualitative study

Background: With the emergence of the coronavirus disease 2019 (COVID-19) and rapid vaccine development, research interest in vaccine hesitancy (VH) has increased. Research usually focuses on quantitative estimates which largely neglected the qualitative underpinnings of this phe- nomenon. This study aimed to explore the beliefs and views towards COVID-19 vaccination among Arabs in different countries. Furthermore, we explored the effect of confidence in the healthcare system, misinformation, and scientific approaches adopted to mitigate COVID-19 on how individuals are following the recommended preventative actions including vaccination. Methods: This study was based on the Strategic Advisory Group of Experts (SAGE)-VH Model: A qualitative design that utilized in-depth, online interviews. The study was conducted in seven Arab countries (Egypt, Qatar, Kingdom of Saudi Arabia, Libya, Sudan, United Arab Emirates and Jordan) from June 2020 to December 2021. Transcripts were analyzed using NVivo 12 Software. Results: A total of 100 participants, 44 males and 56 females, of different age groups (37.1 ± 11.56 years) were interviewed. Findings revealed six themes as enablers and barriers to COVID- 19 vaccination. Many participants indicated trusting the vaccines, the healthcare systems, and the vaccination policies were the main driver to get the vaccine. Participants showed concerns towards potential long-term vaccine effects. A consistent inclination towards collective re- sponsibility, which is the willingness to protect others by own vaccination, was also reported. Conclusion: Enablers and barriers of COVID-19 vaccination acceptance in the Arab region, from sociocultural and political perspectives, are critical to guide policymakers in designing target-oriented interventions that can improve vaccine acceptance.
Dynamic Ionosphere Cubesat Experiment (DICE)

The Dynamic Ionosphere Cubesat Experiment (DICE) mission is due to launch in October 2011 on a NASA rocket from Vandenburg Air Force Base. DICE was selected for flight under the NSF "CubeSat-based Science Mission for Space Weather and Atmospheric Research" program. Space weather refers to conditions in space (the Sun, solar wind, magnetosphere, ionosphere, or thermosphere) that can influence the performance and reliability of spaceborne and ground-based technological systems. Ionospheric variability has a particularly dramatic effect on radio frequency (RF) systems; for example, large gradients in ionospheric electron density can impact communications, surveillance and navigation systems. Some of the largest gradients are found on the edges of Storm Enhanced Density (SED) features, which regularly occur over the US in the afternoon during magnetic disturbances. The DICE mission has three scientific objectives: (1) Investigate the physical processes responsible for formation of the midlatitude ionospheric Storm Enhanced Density (SED) bulge in the noon to post-noon sector during magnetic storms; (2) Investigate the physical processes responsible for the formation of the SED plume at the base of the SED bulge and the transport of the high density SED plume into the polar cap; (3) Investigate the relationship between penetration electric fields and the formation and evolution of SED. The mission consists of two identical Cubesats launched simultaneously into a near circular 600 km, nearly sunsynchronous orbit in the evening sector, precessing to earlier local times. Each satellite carries a fixed-bias DC Langmuir Probe (DCP) to measure in-situ ionospheric plasma densities, and an Electric Field Probe (EFP) to measure DC and AC electric fields. Additionally, a science-grade magnetometer will measure field-aligned currents. These measurements will permit accurate identification of storm-time features such as the SED bulge and plume, together with simultaneous co-located electric field measurements, which have previously been missing. The mission team combines expertise from ASTRA, Utah State University/Space Dynamics Laboratory (USU/SDL), Embry-Riddle Aeronautical University and Clemson University. A large number of students (too many to list) have been involved in building and testing the DICE spacecraft, and this is truly a student experiment.
Runoff sensitivity to global mean temperature change in the CMIP5 Models

We estimated runoff sensitivities to global mean temperature change using climate experiments archived in the Coupled Model Intercomparison Project Phase 5 (CMIP5) and compared with the similar CMIP3 results. We also evaluated differences in runoff sensitivity for the Earth System Models (ESMs) and Climate System Models (CSMs), which were separately identified in CMIP5 for the first time. Our results show that runoff sensitivity is relatively independent of emission scenarios in CMIP5, as in CMIP3 results. Global mean runoff would increase about 2.9% per °C of global warming in CMIP5, as contrasted with 1.9% in CMIP3. Although global runoff sensitivity patterns for CMIP5 and CMIP3 are roughly similar, CMIP5 suggests significant declines (increases) in runoff sensitivity over 17% (25%) of the global land area relative to CMIP3. Globally, the ESMs and CSMs have about the same model spread in runoff change projections.
Imputing genotypes in biallelic populations from low-coverage sequence data 1

Imputing genotypes in biallelic populations from low-coverage sequence data 1 Christopher A. Fragoso, Christopher Heffelfinger, Hongyu Zhao, Stephen L. 2 Dellaporta 3 4 5 Program of Computational Biology and Bioinformatics, Yale University. New Haven, 6 Connecticut 06511, United States of America. 7 8 Department of Molecular, Cellular, and Developmental Biology, Yale University, New 9 Haven, Connecticut 06511, United States of America. 10 11 Department of Biostatistics, Yale School of Public Health, Yale University, New 12 Haven, CT 06510, United States of America 13 14 § Corresponding author 15 stephen.dellaporta@yale.edu 16 17 ** These authors contributed equally to this work. 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 Genetics: Early Online, published on December 29, 2015 as 10.1534/genetics.115. 182071
A Systematic Review on Prognostic Indicators of Acute Liver Failure and Their Predictive Value for Poor Outcome

This review provides a large amount of information, including the extensive list of worldwide used indicators to predict outcome in patients with acute liver failure. There is large heterogeneity in prognostic indicators of acute liver failure, methods of measurement, complexity of calculation and threshold values. Based on this large list of indicators we suggest that an ideal prognostic index should preferentially be based on pathophysiological aspects and has to be applied in a dynamic way. Future studies on acute liver failure can profit from this inventory
National Diabetes Prevention Program.

• Diabetes affects almost 26 million Americans. 1 in 10 U.S. adults have diabetes now. • CDC estimates that as many as 1 in 3 Americans born today will develop diabetes in their lifetime. • Prediabetes affects as many as 79 million persons in the U.S. They are 5 to 15 times more likely to develop type 2 diabetes than persons without prediabetes. • Without access to effective lifestyle intervention, 70% of persons with prediabetes will develop type 2 diabetes during their lifetime. • Prediabetes means your blood glucose (sugar) is higher than normal, but not high enough to be considered diabetes. • Addressing type 2 diabetes in America requires action on prediabetes.
Selecting the Number of Replications in a Simulation Study

In order to approach a distribution by means of simulation it is necessary to determine a number of replications. The accuracy with which the distribution is calculated will rely on this number of replications. In this work, a relationship between the number of replications and the accuracy of the estimate is obtained, so that if it is wanted to get a prefixed value for the accuracy it is possible to determine which will be the minimum number of replications necessary for it.
Flow of variably fluidized granular masses across three‐dimensional terrain: 2. Numerical predictions and experimental tests

Numerical solutions of the equations describing flow of variably fluidized Coulomb mixtures predict key features of dry granular avalanches and water-saturated debris flows measured in physical experiments. These features include time-dependent speeds, depths, and widths of flows as well as the geometry of resulting deposits. Three-dimensional (3-D) boundary surfaces strongly influence flow dynamics because transverse shearing and cross-stream momentum transport occur where topography obstructs or redirects motion. Consequent energy dissipation can cause local deceleration and deposition, even on steep slopes. Velocities of surge fronts and other discontinuities that develop as flows cross 3-D terrain are predicted accurately by using a Riemann solution algorithm. The algorithm employs a gravity wave speed that accounts for different intensities of lateral stress transfer in regions of extending and compressing flow and in regions with different degrees of fluidization. Field observations and experiments indicate that flows in which fluid plays a significant role typically have high-friction margins with weaker interiors partly fluidized by pore pressure. Interaction of the strong perimeter and weak interior produces relatively steep-sided, flat-topped deposits. To simulate these effects, we compute pore pressure distributions using an advection-diffusion model with enhanced diffusivity near flow margins. Although challenges remain in evaluating pore pressure distributions in diverse geophysical flows, Riemann solutions of the depth-averaged 3-D Coulomb mixture equations provide a powerful tool for interpreting and predicting flow behavior. They provide a means of modeling debris flows, rock avalanches, pyroclastic flows, and related phenomena without invoking and calibrating rheological parameters that have questionable physical significance.
Aqua jogging-induced pulmonary oedema

The present study reports the case of a 43-yr-old very sporty male, who developed shortness of breath and expectorated bloody froth during aqua jogging. Pulmonary oedema was diagnosed clinically and by computed tomography of the chest. The patient made a full recovery and his echocardiography was entirely normal. Pulmonary oedema occurring in healthy scuba-divers and swimmers has been reported previously. However, this is the first case where pulmonary oedema was observed during aqua jogging.
Physical Activity and Fitness in Adolescents and Young Adults with Myelomeningocele

textabstractThe introductory Chapter 1 describes the various types of spina bifida, including the most severe myelomeningocele (MMC), and its associated symptoms. Furthermore, it introduces new challenges that rise in medical care with the increased life expectancy of children who are born with this condition. Similarly to persons with other chronic conditions, there is a shift from disability prevention towards prevention of secondary conditions. Sufficient levels of physical activity and fitness are important for disease prevention, maintenance of functional independence, participation and quality of life. Studies on this topic in people with MMC are scarce. Therefore, this thesis aimed to obtain insight in the levels of daily physical activity and fitness of adolescents and young adults with MMC and to study the associations with personal and environmental factors, participation, health-related quality of life and cardiovascular disease (CVD) risk.
Chemoprobe-based assays of histone lysine demethylase 1A target occupation enable in vivo pharmacokinetics and -dynamics studies of KDM1A inhibitors

Screening of cellular activity for inhibitors of histone lysine modifiers is most frequently performed indirectly by analyzing changes in the total levels of histone marks targeted by lysine methylases /demethylases. However, inhibition of histone lysine modifiers often leads to local rather than total changes in histone marks. Also, since histone modifications can be modulated by more than one cellular enzyme, it is not always clear if changes in histone marks are a direct or indirect consequence of the inhibitor treatment applied. Direct assessment of target occupation can provide a useful tool to quantify the fraction of an epigenetic modifier that is bound to a pharmacological inhibitor (target engagement). Here, we developed and used a novel chemoprobe-based immunoassay to quantify target engagement in cells. Quantification of the fraction of free KDM1A was made possible, in an immune-based assay, by coupling a biotinylated chemoprobe to a warhead capable of selectively and irreversibly binding to the free active form of KDM1A. The results obtained confirmed that this approach is able to determine the degree of target engagement in a dose-dependent manner. Furthermore, the assay can be also used on tissue extracts to analyze the in vivo pharmacokinetics and -dynamics relationship of KDM1A inhibitors, as it has been exemplified with ORY-1001 (iadademstat), a potent and irreversible inhibitor of KDM1A. The principle of this assay may be applied to other targets, and the KDM1A probe may be employed in chemoproteomic analyses.