Miracle-dz/UniFAR-FTUs huggingface dataset:
Imaging, myeloid precursor immortalization, and genome editing for defining mechanisms of leukocyte recruitment in vivo

Recruitment of leukocytes from the blood to sites of inflammation poses a promising target for new diagnostic and therapeutic approaches. We aimed to develop a novel method to non-invasively analyze molecular mechanisms of leukocyte migration in pre-clinical models of inflammation in vivo. Methods: We used the ER-HoxB8 system to transiently immortalize murine myeloid precursors from wildtype and CD18- as well as MRP14-deficient mice. A VLA4α-/- cell line was generated by CRISPR/Cas9-mediated gene editing. We analyzed the migration of wildtype and knockout leukocytes in vivo by optical and nuclear imaging in mice with irritant contact dermatitis, cutaneous granuloma, experimental arthritis and myocardial infarction. Results: Transient immortalization, gene editing and in vivo imaging can be combined to analyze migratory mechanisms of murine leukocytes, even for gene deletions resulting in lethal phenotypes in mice. We reliably confirmed known migratory defects of leukocytes deficient for the adhesion molecules CD18 or VLA4α. Also, using our new method we identified a new role of the most abundant calcium-binding proteins in phagocytes and major alarmins in many inflammatory diseases, MRP8 and MRP14, for transmigration in vivo. Conclusion: We provide a combinatorial approach to rapidly characterize molecular mechanisms of leukocyte recruitment in vivo, with the potential to aid in identification of diagnostic and therapeutic targets in inflammatory pathologies.
Decidability and complexity in automatic monoids

We prove several complexity and decidability results for automatic monoids: (i) there exists an automatic monoid with a P-complete word problem, (ii) there exists an automatic monoid such that the first-order theory of the corresponding Cayley-graph is not elementary decidable, and (iii) there exists an automatic monoid such that reachability in the corresponding Cayley-graph is undecidable. Moreover, we show that for every hyperbolic group the word problem belongs to LOGCFL, which improves a result of Cai [4].
A Framework for Searching in Graphs in the Presence of Errors

We consider the problem of searching for an unknown target vertex $t$ in a (possibly edge-weighted) graph. Each \emph{vertex-query} points to a vertex $v$ and the response either admits $v$ is the target or provides any neighbor $s\not=v$ that lies on a shortest path from $v$ to $t$. This model has been introduced for trees by Onak and Parys [FOCS 2006] and for general graphs by Emamjomeh-Zadeh et al. [STOC 2016]. In the latter, the authors provide algorithms for the error-less case and for the independent noise model (where each query independently receives an erroneous answer with known probability $p<1/2$ and a correct one with probability $1-p$). We study this problem in both adversarial errors and independent noise models. First, we show an algorithm that needs $\frac{\log_2 n}{1 - H(r)}$ queries against \emph{adversarial} errors, where adversary is bounded with its rate of errors by a known constant $r<1/2$. Our algorithm is in fact a simplification of previous work, and our refinement lies in invoking amortization argument. We then show that our algorithm coupled with Chernoff bound argument leads to an algorithm for independent noise that is simpler and with a query complexity that is both simpler and asymptotically better to one of Emamjomeh-Zadeh et al. [STOC 2016]. Our approach has a wide range of applications. First, it improves and simplifies Robust Interactive Learning framework proposed by Emamjomeh-Zadeh et al. [NIPS 2017]. Secondly, performing analogous analysis for \emph{edge-queries} (where query to edge $e$ returns its endpoint that is closer to target) we actually recover (as a special case) noisy binary search algorithm that is asymptotically optimal, matching the complexity of Feige et al. [SIAM J. Comput. 1994]. Thirdly, we improve and simplify upon existing algorithm for searching of \emph{unbounded} domains due to Aslam and Dhagat [STOC 1991].
Piebaldism Associated with Neurofibromatosis Type I: A Case Report

Piebaldism is a rare disorder present at birth and inherited as an autosomal dominant trait. It results from a mutation in the c-kit proto-oncogene and is associated with a defect in the migration and differentiation of melanoblasts from the neural crest. We report a 15-year-old girl with both piebaldism and neurofibromatosis type 1 (NF1). She presented with a congenital depigmented patch of the forehead, as well as acquired white forelock, depigmentation of the medial eyebrows, and depigmented patches of the legs. In addition, some cafe au lait macules were observed at birth on the trunk and neck. To our knowledge, the association of piebaldism and NF1 has been described previously in at least 6 case reports. Awareness of this rare association is relevant to ensure early diagnosis and adequate follow-up for NF1.
The association between chronic bullying victimization with weight status and body self-image: a cross-national study in 39 countries

Background Childhood obesity and school bullying are pervasive public health issues and known to co-occur in adolescents. However, the association between underweight or thinness and chronic bullying victimization is unclear. The current study examined whether chronic bullying victimization is associated with weight status and body self-image. Methods A school-based, cross-sectional study in 39 North American and European countries and regions was conducted. A total of 213,595 adolescents aged 11, 13, and 15 years were surveyed in 2009/10. Chronic bullying victimization was identified using the Revised Olweus Bully/Victim Questionnaire. Weight status was determined using self-reported height and weight and the body mass index (BMI), and body self-image was based on perceived weight. We tested associations between underweight and bullying victimization using three-level logistic regression models. Results Of the 213,595 adolescents investigated, 11.28% adolescents reported chronic bullying victimization, 14.80% were classified as overweight/obese according to age- and sex-specific BMI criteria, 12.97% were underweight, and 28.36% considered themselves a little bit fat or too fat, 14.57% were too thin. Bullying victimization was less common in older adolescent boys and girls. Weight status was associated with chronic bullying victimization (adjusted ORunderweight = 1.10, 95% CI = 1.05–1.16, p = 0.002; adjusted ORoverweight = 1.40, 95% CI = 1.32–1.49, p < 0.0001; adjusted ORobese = 1.91, 95% CI = 1.71–2.14, p < 0.0001). Body self-image also related to chronic bullying victimization (adjusted ORtoo thin = 1.42, 95% CI = 1.36–1.49, p < 0.0001; adjusted ORa little bit fat = 1.54, 95% CI = 1.48–1.61, p < 0.0001; adjusted ORtoo fat = 3.30, 95% CI = 2.96–3.68, p < 0.0001). Conclusion Both perceived weight and self-rated overweight are associated with chronic bullying victimization. Both overweight and underweight children are at risk of being chronically bullied.
Statistical inferences for polarity identification in natural language

Information forms the basis for all human behavior, including the ubiquitous decision-making that people constantly perform in their every day lives. It is thus the mission of researchers to understand how humans process information to reach decisions. In order to facilitate this task, this work proposes LASSO regularization as a statistical tool to extract decisive words from textual content in order to study the reception of granular expressions in natural language. This differs from the usual use of the LASSO as a predictive model and, instead, yields highly interpretable statistical inferences between the occurrences of words and an outcome variable. Accordingly, the method suggests direct implications for the social sciences: it serves as a statistical procedure for generating domain-specific dictionaries as opposed to frequently employed heuristics. In addition, researchers can now identify text segments and word choices that are statistically decisive to authors or readers and, based on this knowledge, test hypotheses from behavioral research.
Fate and Survival of Campylobacter coli in Swine Manure at Various Temperatures

Campylobacter coli is the most common Campylobacter species found in pig (95%), but the ability of this bacterium to survive in swine manure as well as the potential for causing human illness are poorly understood. We present here laboratory-scale experiments to investigate the effect of temperature on the survival of C. coli in spiked swine manure samples at temperatures from 4 to 52°C. The survival of C. coli during storage for 30 days was studied by three different methods: bacterial culture (plate counting), DNA qPCR, and mRNA RT-qPCR. The results indicate that C. coli could survive in swine manure up to 24 days at 4°C. At higher temperatures, this bacterium survived only 7 days (15°C) or 6 days (22°C) of storage. The survival of C. coli was extremely short (few hours) in samples incubated at 42 and 52°C. The results from the RT-qPCR method were consistent with the data from the bacterial culture method, indicating that it detected only viable C. coli cells, thus eliminating false-positive resulting from DNA from dead C. coli cells.
Laparoscopic approach compared with conventional open approach for bezoar-induced small-bowel obstruction.

BACKGROUND Bezoar-induced small-bowel obstruction (SBO) is an uncommon surgical emergency. Accurate preoperative diagnosis is notoriously difficult, and conventional management often necessitates laparotomy. Recent articles demonstrate the feasibility of laparoscopy in the management of SBO. This study compares the outcomes of a series of cases managed laparoscopically with the outcomes of matched open cases. HYPOTHESIS Laparoscopic management of bezoar-induced SBO is safe and effective when compared with traditional laparotomy treatment. PATIENTS AND METHODS A retrospective study was conducted from November 1, 1998, to November 30, 2003, to compare laparoscopic vs open treatment for bezoar-induced SBO. Patients' demographics, operative details, and surgical outcomes were evaluated. RESULTS During the study period, 24 patients (16 men and 8 women) with a mean age of 68.2 years underwent operative treatments for bezoar-induced SBO. Ten patients received laparoscopic treatments and the other 14 received laparotomy treatments. The patients were comparable in age, sex, and physiological status. There were 3 conversions in the laparoscopy group owing to technical difficulties. The laparoscopic approach was associated with statistically significant shorter operative time (P = .048), fewer postoperative complications (P = .04), and reduced hospital stay (P = .009). CONCLUSIONS When expertise is available, laparoscopy is safe and effective in the management of bezoar-induced SBO and is associated with superior postoperative outcomes when compared with the conventional open approach.
Development of fever following first administration of zoledronate as a prognostic factor in advanced non-small cell lung cancer patients with bone metastases

Nitrogen-containing bisphosphonates (N-BPs), which are usually used for the treatment of advanced cancer with bone metastasis, occasionally cause fever following the first administration. However, it is unclear as to how the development of fever following the first administration of N-BP is associated with clinical outcome. The aim of the present study was to determine the prognostic value of the development of fever following the first administration of N-BP in advanced non-small cell lung cancer patients with bone metastases. The present study reviewed the data of 46 patients with advanced non-small cell lung cancer who were administered zoledronate (ZOL), an N-BP, for bone metastasis, between March 2009 and March 2011 in the Department of Medical Respirology at Tottori University Hospital. Clinicopathological factors were evaluated using univariate and multivariate analyses, and these factors were compared between the fever and non-fever groups. Of the 46 patients, 15 (32.6%) developed fever following the first administration of ZOL. No significant differences were observed in the clinicopathological characteristics between the two groups. The overall survival in the fever group was significantly longer compared with the non-fever group (median survival time: 33.4 vs. 15.7 months, P=0.04), and the development of fever following the first ZOL administration was independently associated with longer overall survival. The development of fever following the first ZOL administration was an independent prognostic factor in advanced non-small cell lung cancer patients with bone metastases. Thus, ZOL-associated fever may be a predictive factor for an undefined, survival-promoting effect of ZOL.
Tribochemical Characterization and Tribocorrosive Behavior of CoCrMo Alloys: A Review

Orthopedic implants first started out as an all-metal hip joint replacement. However, poor design and machinability as well as unsatisfactory surface finish subjected the all-metal joint replacement to being superseded by a polyethylene bearing. Continued improvement in manufacturing techniques together with the reality that polyethylene wear debris can cause hazardous reactions in the human body has brought about the revival of metal-on-metal (MOM) hip joints in recent years. This has also led to a relatively new research area that links tribology and corrosion together. This article aims at reviewing the commonly used tribochemical methods adopted in the analysis of tribocorrosion and putting forward some of the models and environmental factors affecting the tribocorrosive behavior of CoCrMo alloys, a widely-used class of biomaterial for orthopedic implants.
Short-term antidepressant treatment and facial processing

Summary We used functional magnetic resonance imaging to investigate the effects of short-term treatment with reboxetine, a selective noradrenaline reuptake inhibitor, on emotional facial processing in healthy volunteers. Reboxetine was associated with a reduced amygdala response to fearful faces and increased activation to happy v. neutral facial expressions in the right fusiform gyrus, relative to placebo treatment and in the absence of changes in mood. Our results show that reboxetine modulates the neural substrates of emotional processing, highlighting a mechanism by which drug treatment could normalise negative bias in depression and anxiety.
Associations of individual and family eating patterns during childhood and early adolescence: a multicentre European study of associated eating disorder factors

The objective of this study was to examine whether there is an association between individual and family eating patterns during childhood and early adolescence and the likelihood of developing a subsequent eating disorder (ED). A total of 1664 participants took part in the study. The ED cases (n 879) were referred for assessment and treatment to specialized ED units in five different European countries and were compared to a control group of healthy individuals (n 785). Participants completed the Early Eating Environmental Subscale of the Cross-Cultural (Environmental) Questionnaire, a retrospective measure, which has been developed as part of a European multicentre trial in order to detect dimensions associated with ED in different countries. In the control group, also the General Health Questionnaire-28 (GHQ-28), the semi-structured clinical interview (SCID-I) and the Eating Attitudes Test (EAT-26) were used. Five individually Categorical Principal Components Analysis (CatPCA) procedures were adjusted, one for each theoretically expected factor. Logistic regression analyses indicated that the domains with the strongest effects from the CatPCA scores in the total sample were: food used as individualization, and control and rules about food. On the other hand, healthy eating was negatively related to a subsequent ED. When differences between countries were assessed, results indicated that the pattern of associated ED factors did vary between countries. There was very little difference in early eating behaviour on the subtypes of ED. These findings suggest that the fragmentation of meals within the family and an excessive importance given to food by the individual and the family are linked to the later development of an ED.
Preparing arbitrary pure states of spatial qudits with a single phase-only spatial light modulator

We present a new method for preparing multidimensional spatial qudits by means of a single phase-only spatial light modulator (SLM). This method improves previous ones that use two SLMs, one working in amplitude regime and the other in phase regime. To that end, we addressed diffraction gratings on the slits that define the state and then we performed a spatial filtering in the Fourier plane. The amplitude of the coefficients of the quantum state are determined by the modulation deep of the diffraction gratings, and the relative phase is the mean phase value of the diffraction gratings. This encoding result to be more compact, less expensive and use the photons more efficiently.
Highly-Sensitive Humidity Sensors for Condition Monitoring of Hybrid Laminates

In recent years fibre-reinforced polymers (FRPs) gained importance in a wider field of application due to such favourable properties as low mass and tailorable mechanical strength. However, water penetrating into the lightweight material can lead to a loss of shear strength and finally to a collapse of the whole mechanical structure. Consequently, the integration of humidity sensors into compound materials is able to promote the reliability via online condition monitoring. An innovative concept is the use of ceramics-polymer-composites, which are well suited for the integration into lightweight structures during inline production. Composite and polyimide based humidity sensors have been manufactured by flexographic printing and spin-coating processes. A 5-fold increase in sensor’s capacity related to a humidity change from 10 to 80 % r.h. manifests the outstanding sensitivity of manufactured composite sensors. In addition, FRP-integrated polyimide sensors showed a significant response to water penetration, whereby the capability of condition monitoring could be confirmed.
Nutrition labels on pre-packaged foods: a systematic review

Abstract Objective To review research on consumer use and understanding of nutrition labels, as well as the impact of labelling on dietary habits. Design A systematic review was conducted by searching electronic databases. Relevant articles were screened by two reviewers and included if they met inclusion criteria, including eight methodological criteria. A total of 120 articles were included in the review, including cross-sectional surveys (n 96), experimental designs (n 17), ‘natural experiments’ (n 7) and longitudinal population-based surveys (n 2). Setting Articles covered seven jurisdictions: USA (n 88), Europe (n 12), Canada (n 9), Australia and New Zealand (n 4), Norway (n 2), Thailand (n 1) and Trinidad (n 1). Subjects Participants were from a wide range of age groups, socio-economic strata and geographical regions. Results Nutrition labels on pre-packaged foods are among the most prominent sources of nutrition information. Nutrition labels are perceived as a highly credible source of information and many consumers use nutrition labels to guide their selection of food products. Evidence also shows a consistent link between the use of nutrition labels and healthier diets. However, the use of labels varies considerably across subgroups, with lower use among children, adolescents and older adults who are obese. Research also highlights challenges in terms of consumer understanding and appropriate use of labelling information. Conclusions Nutrition labels on pre-packaged foods are a cost-effective population-level intervention with unparalleled reach. However, to capitalize on their potential, governments will need to explore new formats and different types of information content to ensure that nutrition information is accessible and understandable.
Long-term exposure to air pollution and type 2 diabetes mellitus in a multiethnic cohort.

Although air pollution has been suggested as a possible risk factor for type 2 diabetes mellitus (DM), results from existing epidemiologic studies have been inconsistent. We investigated the associations of prevalence and incidence of DM with long-term exposure to air pollution as estimated using annual average concentrations of particulate matter with an aerodynamic diameter of 2.5 μm or less (PM₂.₅) and nitrogen oxides at baseline (2000) in the Multi-Ethnic Study of Atherosclerosis. All participants were aged 45-84 years at baseline and were recruited from 6 US sites. There were 5,839 participants included in the study of prevalent DM and 5,135 participants without DM at baseline in whom we studied incident DM. After adjustment for potential confounders, we found significant associations of prevalent DM with PM₂. ₅ (odds ratio (OR) = 1.09, 95% confidence interval (CI): 1.00, 1.17) and nitrogen oxides (OR = 1.18, 95% CI: 1.01, 1.38) per each interquartile-range increase (2.43 µg/m(3) and 47.1 ppb, respectively). Larger but nonsignificant associations were observed after further adjustment for study site (for PM₂.₅, OR = 1.16, 95% CI: 0.94, 1.42; for nitrogen oxides, OR = 1.29, 95% CI: 0.94, 1.76). No air pollution measures were significantly associated with incident DM over the course of the 9-year follow-up period. Results were partly consistent with a link between long-term exposure to air pollution and the risk of type 2 DM. Additional studies with a longer follow-up time and a greater range of air pollution exposures, including high levels, are warranted to evaluate the hypothesized association.
Advanced dental disease in people with severe mental illness: systematic review and meta-analysis

Background Psychiatric patients have increased comorbid physical illness. There is less information concerning dental disease in this population in spite of risk factors including diet and psychotropic side-effects (such as xerostomia). Aims To compare the oral health of people with severe mental illness with that of the general population. Method A systematic search for studies from the past 20 years was conducted using Medline, PsycINFO, Embase and article bibliographies. Papers were independently assessed. The primary outcome was total tooth loss (edentulousness), the end-stage of both untreated caries and periodontal disease. We also assessed dental decay through standardised measures: the mean number of decayed, missing and filled teeth (DMFT) or surfaces (DMFS). For studies lacking a control group we used controls of similar ages from a community survey within 10 years of the study. Results We identified 21 papers of which 14 had sufficient data (n = 2784 psychiatric patients) and suitable controls (n = 31 084) for a random effects meta-analysis. People with severe mental illness had 3.4 times the odds of having lost all their teeth than the general community (95% CI 1.6–7.2). They also had significantly higher scores for DMFT (mean difference 6.2, 95% CI 0.6–11.8) and DMFS (mean difference 14.6, 95% CI 4.1–25.1). Fluoridated water reduced the gap in oral health between psychiatric patients and the general population. Conclusions Psychiatric patients have not shared in the improving oral health of the general population. Management should include oral health assessment using standard checklists that can be completed by non-dental personnel. Interventions include oral hygiene and management of xerostomia.