Miracle-dz/UniFAR-FTUs huggingface dataset:
Sphere decoding algorithm for multiuser detection in a distributed antenna system

In this paper, the impact of initial search radius on the complexity and performance of a sphere decoding algorithm is investigated for different user positions within a distributed antenna system. In a distributed antenna system, users can take up random positions within the cell clusters. The channel matrix can therefore take up infinitely different forms. In the presented work, a distributed antenna system with three different user positions in the cooperating cells is considered by employing different channel matrices. The effect on the complexity and performance of the sphere decoder due to the choice of the initial sphere radius is investigated for these user positions. It is shown that the signal lattice volume changes considerably for different user positions within the cells. A dynamic radius allocation algorithm is proposed in which the behavior is exploited by dynamically adjusting the initial sphere radius based on the knowledge of the channel path gain matrix. The simulation results show that the proposed algorithm results in a considerable reduction in the complexity of the sphere decoder in a distributed antenna system. Additionally, the performance of the sphere decoder in different coupling scenarios within the distributed antenna system has been investigated for a different number of candidates. It is shown that the performance of cell edge users can be considerably enhanced with high channel diversity, which otherwise could severely deteriorate the overall system performance.
New lactic acid bacteria for skin health via oral intake of heat‐killed or live cells

Abstract Lactic acid bacteria play an essential role in the food industry in the manufacture of many fermented products (cheese, yogurt, fermented vegetables, etc.). Application of these organisms is now being extended to the area of health improvement, as their probiotic activities become known. Probiotics are defined as viable microorganisms that exert a beneficial effect on the health of the host when they are ingested in sufficient quantity. Lactic acid bacteria and bifidobacteria isolated from the human intestine are the most common probiotics used for human consumption. The development of new probiotics with new beneficial effects is eagerly awaited in the food industry. This review introduces Lactococcus, which are one of the genera of lactic acid bacteria and are mainly isolated from dairy products and fermented vegetables, as new probiotics, focusing especially on Lactococcus lactis H61, which improves skin status in Japanese women with oral intake of heat‐killed or live cells. The deduced mechanisms associated with the beneficial effects of strain H61 are also discussed.
12 Chronic Obstructive Pulmonary Disease and Diabetes Mellitus

The progressive increase in the average age of the population leads to chronic diseases that are increasingly important. Chronic conditions are large in number, the prevalence of each one is high and so does the annual cost of their care. Moreover, clinicians alert about the impact of one disease on the development and severity of others. Among chronic morbidities the most prevalent are cardiovascular disease (CV), cancer, diabetes mellitus (DM) and chronic obstructive pulmonary disease (COPD) (Chillón et al., 2009). Noticeably, a 25% of patients older than 65 years have two chronic conditions and this figure rises to 40% in population over 75 years old (Chatila et al., 2008).
Remote Sensing for Characterisation and Kinematic Analysis of Large Slope Failures: Debre Sina Landslide, Main Ethiopian Rift Escarpment

Frequently occurring landslides in Ethiopia endanger rapidly expanding settlements and infrastructure. We investigated a large landslide on the western escarpment of the Main Ethiopian Rift close to Debre Sina. To understand the extent and amplitude of the movements, we derived vectors of horizontal displacements by feature matching of very high resolution satellite images (VHR). The major movements occurred in two phases, after the rainy seasons in 2005 and 2006 reaching magnitudes of 48 ± 10.1 m and 114 ± 7.2 m, respectively. The results for the first phase were supported by amplitude tracking using two Envisat/ASAR scenes from the 31 July 2004 and the 29 October 2005. Surface changes in vertical direction were analyzed by subtraction of a pre-event digital elevation model (DEM) from aerial photographs and post-event DEM from ALOS/PRISM triplet data. Furthermore, we derived elevation changes using satellite laser altimetry measurement acquired by the ICESat satellite. These analyses allowed us to delineate the main landslide, which covers an area of 6.5 km2, shallow landslides surrounding the main landslide body that increased the area to 8.5 km2, and the stable area in the lower part of the slope. We assume that the main triggering factor for such a large landslide was precipitation cumulated over several months and we suspect that the slope failure will progress towards the foot of the slope.
Multiple Testing with Minimal Assumptions

Resampling‐based multiple testing methods that control the Familywise Error Rate in the strong sense are presented. It is shown that no assumptions whatsoever on the data‐generating process are required to obtain a reasonably powerful and flexible class of multiple testing procedures. Improvements are obtained with mild assumptions. The methods are applicable to gene expression data in particular, but more generally to any multivariate, multiple group data that may be character or numeric. The role of the disputed “subset pivotality” condition is clarified. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Surgery and neurointervention for intracranial atherosclerotic steno-occlusive disease

Neurosurgeons and neurointerventionists interested in cerebral revascularisation to prevent stroke from intracranial atherosclerotic steno-occlusive disease were disappointed in 2011 with the closure of two important negative studies: the Carotid Occlusion Surgery Study (COSS) and Stenting and Aggressive Medical Therapy for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) study. Debates are centred on what causes these failures. While extracranial-intracranial (EC-IC) bypass and neurointervention (angioplasty and/ or stenting) cannot be considered a routine intervention for patients presenting with initial ischaemic event in the setting of atherosclerotic steno-occlusive disease, selected patients with severe haemodynamic impairment and/or recurrent symptoms despite maximal medical therapy may still benefit from surgery and neurointervention at high-volume centres, which can offer the procedure with low perioperative morbidity.
Neural correlates of language variability in preschool‐aged boys with autism spectrum disorder

Children with autism vary widely in their language abilities, yet the neural correlates of this language variability remain unclear, especially early in development. Diffusion tensor imaging (DTI) was used to examine diffusivity measures along the length of 18 major fiber tracts in 104 preschool‐aged boys with autism spectrum disorder (ASD). The boys were assigned to subgroups according to their level of language development (Low: no/low language, Middle: small vocabulary, High: large vocabulary and grammar), based on their raw scores on the expressive language (EL) and receptive language (RL) sections of the Mullen Scales of Early Learning (MSEL). Results indicate that the subgroups differed in fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD) along the inferior longitudinal fasciculus (ILF) in both hemispheres. Moreover, FA correlated significantly with Mullen EL and RL raw scores, but not ADOS severity score, along the left and right ILF. Subgroups also differed in MD (but not FA) along the left superior longitudinal fasiculus and left corticospinal tract, but these differences were not correlated with language scores. These findings suggest that white matter microstructure in the left and right ILF varies in relation to lexical development in young males with ASD. The findings also support the use of raw scores on language‐relevant standardized tests for assessing early language‐brain relationships. Autism Res 2017. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Autism Res 2017, 10: 1107–1119. © 2017 International Society for Autism Research, Wiley Periodicals, Inc.
Effects of the sesquiterpene lactone parthenolide on prostate tumor‐initiating cells: An integrated molecular profiling approach

Recent evidence suggests tumor‐initating cells (TICs), also called cancer stem cells, are responsible for tumor initiation and progression; therefore, they represent an important cell population for development of future anti‐cancer therapies. In this study, we show that the sesquiterpene lactone parthenolide (PTL) is cytotoxic to prostate TICs isolated from prostate cancer cell lines: DU145, PC3, VCAP, and LAPC4, as well as primary prostate TICs. Furthermore, PTL inhibited TIC‐driven tumor formation in mouse xenografts. Using an integrated molecular profiling approach encompassing proteomics, profiles of activated transcription factors and genomics we ascertained the effects of PTL on prostate cancer cells. In addition to the previously described effects of PTL, we determined that the non‐receptor tyrosine kinase src, and many src signaling components, including: Csk, FAK, β1‐arrestin, FGFR2, PKC, MEK/MAPK, CaMK, ELK‐1, and ELK‐1‐dependent genes are novel targets of PTL action. Furthermore, PTL altered the binding of transcription factors important in prostate cancer including: C/EBP‐α, fos related antigen‐1 (FRA‐1), HOXA‐4, c‐MYB, SNAIL, SP1, serum response factor (SRF), STAT3, X‐box binding protein‐1 (XBP1), and p53. In summary, we show PTL is cytotoxic to prostate TICs and describe the molecular events of PTL‐mediated cytotoxicity. Therefore, PTL represents a promising therapeutic for prostate cancer treatment. Prostate 69: 827–837, 2009. © 2009 Wiley‐Liss, Inc.
A new numerical scheme for a class of reflected stochastic differential equations

Abstract. We propose a new numerical scheme for a class of one-dimensional reflected stochastic differential equations (SDEs) by virtue of their explicit solutions, which enables us to carry out the simulation of this class of reflected SDEs by simulating some related SDEs without reflections. The new scheme yields the same order of convergence as the scheme for SDEs without reflections.
Modeling and design of a low-voltage SOI suspended-gate MOSFET (SG-MOSFET) with a metal-over-gate architecture

A novel MEMS device architecture: the SOI SG-MOSFET, which combines a solid-state MOS transistor and a suspended metal membrane in a unique metal-over-gate architecture, is proposed. A unified physical analytical model (weak, moderate and strong inversions) is developed and used to investigate main electrostatic characteristics in order to provide first-order design criteria for low-voltage operation and high-performance. It is demonstrated that the use of a thin gate oxide (<20 nm) is essential for a high C/sub on//C/sub off/ ratio (>100) and a low spring constant (<100 N/m) is needed for low voltage (<5 V) actuation. An adapted fabrication process is reported.
Autonomous underwater vehicles for submarine cable inspection: experimental results

In this paper, a sensor fusion technique is proposed for autonomous underwater vehicles (AUV) to track underwater cables. The focus of this paper is to solve the two practical problems encountered in optical vision based systems in underwater environments; namely 1) navigation of AUV when cable is invisible in the image, and 2) selection of the correct cable (interested feature) when there are many similar features appearing in the image. The proposed sensor fusion scheme uses dead reckoning position uncertainty with a 2D position model of the cable to predict the region of interest in the image. This reduces the processing data increasing the processing speed and avoids tracking other similar features appearing in the optical image. The proposed method uses a priori map of the cable for AUV navigation when the cable features are invisible in the predicted region in the image. An experiment is conducted to test the performance of the proposed algorithm using the AUV "Twin-Burger 2". The experimental results presented in this paper show how the proposed method handles the above-mentioned practical problems.
Dequalinium, a New Inhibitor of Mycobacterium tuberculosis Mycothiol Ligase Identified by High-Throughput Screening

Mycothiol ligase (MshC) is a key enzyme in the biosynthesis of mycothiol, a small molecular weight thiol that is unique to actinomycetes and whose primary role is to maintain intracellular redox balance and remove toxins. MshC catalyzes the adenosine triphosphate (ATP)—dependent condensation of cysteine and glucosamine-inositol (GI) to produce cysteine-glucosamine-inositol (CGI). MshC is essential to Mycobacterium tuberculosis and therefore represents an attractive target for chemotherapeutic intervention. A screening protocol was developed to identify MshC inhibitors based on quantification of residual ATP using a coupled luminescent assay. The protocol was used to screen a library of 3100 compounds in a 384-well plate format (Z′ ≥ 0.65). Fifteen hits (0.48%) were identified from the screen, and 2 hits were confirmed in a secondary assay that measures production of CGI. The structures of both hits contain N-substituted quinolinium moieties, and the more potent of the 2—namely, dequalinium chloride—inhibits MshC with an IC50 value of 24 ± 1 µM. Further studies showed dequalinium to be an ATP-competitive inhibitor of MshC, to bind MshC with a KD of 0.22 µM, and to inhibit the growth of M. tuberculosis under aerobic and anaerobic conditions with minimum inhibitory and anaerobic bactericidal concentrations of 1.2 and 0.3 µg/mL, respectively. The screening protocol described is robust and has enabled the identification of new MshC inhibitors. (Journal of Biomolecular Screening 2009:643-652)
Whole-Genome Sequences of Two Campylobacter coli Isolates from the Antimicrobial Resistance Monitoring Program in Colombia

ABSTRACT Campylobacter coli, along with Campylobacter jejuni, is a major agent of gastroenteritis and acute enterocolitis in humans. We report the whole-genome sequences of two multidrug-resistance C. coli strains, isolated from the Colombian poultry chain. The isolates contain a variety of antimicrobial resistance genes for aminoglycosides, lincosamides, fluoroquinolones, and tetracycline.
How Are Spousal Depressed Mood, Distress, and Quality of Life Associated with Risk of Depressed Mood in Cancer Survivors? Longitudinal Findings from a National Sample

Background: Spouses of cancer survivors experience both positive and negative effects from caregiving. However, it is less clear what role spousal well-being may have on cancer survivors. This study aimed to determine the impact of spousal psychosocial factors on survivor depressed mood and whether this association differed by gender. Methods: We examined longitudinal data on cancer survivors and their spouses (n = 910 dyads) from the 2004–2012 Medical Expenditures Panel Survey and a matched sample of cancer-free dyads. Subjects reported depressed mood, psychologic distress, and mental and physical health-related quality of life (HRQoL) at two time points (T1/T2). Dyadic multilevel models evaluated the impact of psychosocial factors at T1 on depressed mood at T2, controlling for sociodemographics, cancer type, survivor treatment status, and depressed mood at T1. Results: Cancer survivors whose spouses reported depressed mood at T1 were 4.27 times more likely to report depressed mood at T2 [95% confidence interval (CI), 2.01–9.07]; this was stronger for female survivors (OR, 9.49; 95% CI, 2.42–37.20). Better spousal mental and physical HRQoL at T1 were associated with a 30% decrease in survivor depressed mood risk at T2. Most spillover effects were not observed in comparison dyads. Conclusion: Depressed mood and poor HRQoL in spouses may increase the risk of depressed mood in cancer survivors. The risk may be especially strong for female survivors. Impact: Identifying and improving spousal mental health and HRQoL problems may reduce the risk of depressed mood in cancer survivors. Future research should examine whether incorporating spousal care into psychooncology and survivorship programs improves survivor outcomes. Cancer Epidemiol Biomarkers Prev; 24(6); 969–77. ©2015 AACR.
A continuum damage model based on Ottosen's four parameter failure criterion for concrete

In this paper, a thermodynamic formulation for modelling anisotropic damage of elastic-brittle materials based on Ottosen’s 4-parameter failure surface is proposed. The model is developed by using proper expressions for the specific Gibbs free energy and the complementary form of the dissipation potential. The formulation predicts the behaviour of the material relevantly and suggests a realistic shape for the damage surface.
Research of Multi-Path Routing Protocol Based on Parallel Ant Colony Algorithm Optimization in Mobile Ad Hoc Networks

In the research of routing protocol in the ad hoc networks, single path routing protocol, known as ad hoc on-demand distance vector, has attracted the attention of scholars. At present ants-based routing algorithms have been widely studied because they are suitable for mobile ad-hoc networks where nodes move dynamically and topology changes frequently. Study shows when the number of nodes increases, however, the number of ants (control messages) also increases, which means poor scalability. The proposed routing protocol in this paper applies the parallel ant colony algorithm to establish multi-path routing between source node and destination node, and it improves the packet delivery performance greatly. We also describe the strategy of information exchange and the refresh rules of pheromone in the parallel ACO. In simulation experiments of NS 2.28 the proposed protocol reduces route discovery latency and the end-to-end delay by providing high connectivity without requiring much of the scarce network capacity. Meanwhile the parallel ACO can improve the probability of rout discovery and the speed of constringency is obviously increased in ad hoc networks.
Varied Role of Ubiquitylation in Generating MHC Class I Peptide Ligands

CD8+ T cell immunosurveillance is based on recognizing oligopeptides presented by MHC class I molecules. Despite decades of study, the importance of protein ubiquitylation to peptide generation remains uncertain. In this study, we examined the ability of MLN7243, a recently described ubiquitin-activating enzyme E1 inhibitor, to block overall cytosolic peptide generation and generation of specific peptides from vaccinia- and influenza A virus–encoded proteins. We show that MLN7243 rapidly inhibits ubiquitylation in a variety of cell lines and can profoundly reduce the generation of cytosolic peptides. Kinetic analysis of specific peptide generation reveals that ubiquitylation of defective ribosomal products is rate limiting in generating class I peptide complexes. More generally, our findings demonstrate that the requirement for ubiquitylation in MHC class I–restricted Ag processing varies with class I allomorph, cell type, source protein, and peptide context. Thus, ubiquitin-dependent and -independent pathways robustly contribute to MHC class I–based immunosurveillance.
Searching for biomarkers: humoral response profiling with luciferase immunoprecipitation systems

B-cell-mediated humoral responses are triggered in many human diseases, including autoimmune diseases, cancer, and neurologic and infectious diseases. However, the full exploitation of the information contained within a patient’s antibody repertoire for diagnosis, monitoring and even disease prediction has been limited due to the poor diagnostic performance of many immunoassay formats. We have developed luciferase immunoprecipitation systems (LIPS) that harnesses light-emitting proteins to generate high-definition antibody profiles that are optimal for both diagnostics and biomarker discovery. Here, we describe the results and implications from a range of LIPS-antibody profiling studies performed in our laboratory. These include highly sensitive diagnostics for domestic and global pathogens, insights into infection-related diseases, discovery of new biomarkers for human diseases, subcategorization of symptoms and identification of pathogenic autoantibodies against self-proteins. These investigations highlight the types of humoral response profiles associated with different diseases, provide new information related to disease pathogenesis and offer a framework for incorporating LIPS antibody profiling into global health initiatives and disease monitoring.
The nonmotor adaptor HMMR dampens Eg5-mediated forces to preserve the kinetics and integrity of chromosome segregation

The nonmotor adaptor protein HMMR maintains the kinetics and integrity of chromosome segregation by promoting TPX2-Eg5 complexes that dampen Eg5-mediated forces and support K-fiber stability, kinetochore–microtubule attachments, and inter-kinetochore tension. HMMR is needed to prevent the generation of aneuploid progeny cells.
Deformation Quantization of Poisson Structures Associated to Lie Algebroids

In the present paper we explicitly construct deformation quantizations of certain Poisson structures on E , where E ! M is a Lie algebroid. Although the considered Poisson structures in general are far from being regular or even symplectic, our construction gets along without Kontsevich's formality theorem but is based on a generalized Fedosov construction. As the whole construction merely uses geometric structures of E we also succeed in determining the dependence of the resulting star products on these data in finding appropriate equivalence transformations between them. Finally, the concreteness of the construction allows to obtain explicit formulas even for a wide class of derivations and self- equivalences of the products. Moreover, we can show that some of our products are in direct relation to the universal enveloping algebra associated to the Lie algebroid. Finally, we show that for a certain class of star products on E the integration with respect to a density with vanishing modular vector field defines a trace functional.
Expression of a Variant Form of the Glutamate Transporter GLT1 in Neuronal Cultures and in Neurons and Astrocytes in the Rat Brain

To identify glutamate transporters expressed in forebrain neurons, we prepared a cDNA library from rat forebrain neuronal cultures, previously shown to transport glutamate with high affinity and capacity. Using this library, we cloned two forms, varying in the C terminus, of the glutamate transporter GLT1. This transporter was previously found to be localized exclusively in astrocytes in the normal mature brain. Specific antibodies against the C-terminal peptides were used to show that forebrain neurons in culture express both GLT1a and GLT1b proteins. The pharmacological properties of glutamate transport mediated by GLT1a and GLT1b expressed in COS-7 cells and in neuronal cultures were indistinguishable. Both GLT1a and GLT1b were upregulated in astrocyte cultures by exposure to dibutyryl cAMP. We next investigated the expression of GLT1bin vivo. Northern blot analysis of forebrain RNA revealed two transcripts of ∼3 and 11 kb that became more plentiful with developmental age. Immunoblot analysis showed high levels of expression in the cortex, hippocampus, striatum, thalamus, and midbrain. Pre-embedding electron microscopic immunocytochemistry with silver-enhanced immunogold detection was used to localize GLT1bin vivo. In the rat somatosensory cortex, GLT1b was clearly expressed in neurons in presynaptic terminals and dendritic shafts, as well as in astrocytes. The presence of GLT1b in neurons may offer a partial explanation for the observed uptake of glutamate by presynaptic terminals, for the preservation of input specificity at excitatory synapses, and may play a role in the pathophysiology of excitotoxicity.