Miracle-dz/UniFAR-FTUs huggingface dataset:
Novel technologies to detect atelectotrauma in the injured lung

ABSTRACT Cyclical recruitment and derecruitment of lung parenchyma (R/D) remains a serious problem in ALI/ARDS patients, defined as atelectotrauma. Detection of cyclical R/D to titrate the optimal respiratory settings is of high clinical importance. Image-based technologies that are capable of detecting changes of lung ventilation within a respiratory cycle include dynamic computed tomography (dCT), synchrotron radiation computed tomography (SRCT), and electrical impedance tomography (EIT). Time-dependent intra-arterial oxygen tension monitoring represents an alternative approach to detect cyclical R/D, as cyclical R/D can result in oscillations of PaO2 within a respiratory cycle. Continuous, ultrafast, on-line in vivo measurement of PaO2 can be provided by an indwelling PaO2 probe. In addition, monitoring of fast changes in SaO2 by pulse oximetry technology at the bedside could also be used to detect those fast changes in oxygenation.
Fosfomycin for the Treatment of Resistant Gram‐Negative Bacterial Infections

The antimicrobial agent fosfomycin was discovered in 1969, at a time when bacteria had not yet developed extended‐spectrum β‐lactamases or carbapenemases. Decades later, it is not uncommon for gram‐negative organisms to be multidrug‐resistant and even pan‐resistant to available antibiotic regimens, leaving clinicians with few therapeutic alternatives. Because fosfomycin has been shown to retain activity against these virulent pathogens, there is renewed interest in its use as a therapeutic agent. Fosfomycin formulations including fosfomycin disodium and the newer tromethamine salt are less toxic than other alternatives and are attractive options for resistant gram‐negative and gram‐positive infections. Oral fosfomycin tromethamine is approved for urinary tract infections in the United States, and an intravenous formulation is also available outside of the United States for systemic disease. The bactericidal action of fosfomycin occurs at an earlier step in cell wall synthesis than that of β‐lactam antibiotics. From an in vitro standpoint, fosfomycin generally has high activity against ESBL‐ and carbapenemase‐producing Enterobacteriaceae; multidrug‐resistant Pseudomonas aeruginosa susceptibility appears to be more dependent on the local antibiogram. Fosfomycin formulations have a large volume of distribution, penetrate biofilms, and concentrate in the urine. Both oral and intravenous fosfomycin formulations are effective for a wide range of gram‐negative infections and disease severities; however, clinical studies are limited. Fosfomycin formulations are well‐tolerated, and mild gastrointestinal distress is the most common adverse effect. The primary limitations of fosfomycin are the lack of established regimens for complicated infections and the lack of availability of the intravenous formulation in the United States. Further study of this promising agent seems warranted in the current climate of antibiotic resistance.
Enantioselective Pharmacokinetics of Primaquine in Healthy Human Volunteers

Primaquine (PQ), a racemic drug, is the only treatment available for radical cure of relapsing Plasmodium vivax malaria and blocking transmission of P. falciparum malaria. Recent studies have shown differential pharmacologic and toxicologic profiles of individual PQ enantiomers in rodent, dog, and primate animal models. This study was conducted in six healthy adult human volunteers to determine the plasma pharmacokinetic profile of enantiomers of PQ and carboxyprimaquine (cPQ), the major plasma metabolite. The individuals were orally administered PQ diphosphate, equivalent to 45-mg base, 30 minutes after a normal breakfast. Blood samples were collected at different time intervals, and plasma samples were analyzed for enantiomers of PQ and cPQ. Plasma PQ concentrations were low and variable for both parent enantiomers and peaked around 2-4 hours. Peak (−)-(R)-PQ concentrations ranged from 121 ng/ml to 221 ng/ml, and peak (+)-(S)-PQ concentrations ranged from 168 ng/ml to 299 ng/ml. The cPQ concentrations were much higher and were surprisingly consistent from subject to subject. Essentially all the cPQ detected in plasma was (−)-cPQ. The peak concentrations of (−)-cPQ were observed at 8 hours (range: 1104-1756 ng/ml); however, very high concentrations were sustained through 24 hours. (+)-cPQ was two orders of magnitude lower than (−)-cPQ, and in a few subjects it was detected but only under the limit of quantification. In vitro studies with primary human hepatocytes also suggested more rapid metabolism of (−)-PQ compared with (+)-PQ. The results suggest more rapid metabolism of (−)-PQ to (−) cPQ compared with (+)-PQ. Alternatively, (+)-PQ or (+)-cPQ could be rapidly converted to another metabolite(s) or distributed to tissues. This is the first clinical report on enantioselective pharmacokinetic profiles of PQ and cPQ and supports further clinical evaluation of individual PQ enantiomers.
Takagi Sugeno Fuzzy Sliding Mode Controller Design for a Class of Nonlinear System

This paper presents with the synthesis of fuzzy sliding mode controller nonlinear system based on Takagi Sugeno (T-S) fuzzy model. The concepts of state feedback control and Lyapunov functional approach is utilized in deriving the sufficient condition for robust stable which then formulated in the forms of linear matrix inequalities (LMI). Therefore the global asymptotically stability of sliding mode control (SMC) for a class of nonlinear systems via Takagi Sugeno fuzzy model is guaranteed. An example is given to demonstrate the feasibility and effectiveness of this approach.
Group Activity Recognition with Group Interaction Zone Based on Relative Distance Between Human Objects

In this paper, we address the problem of recognizing group activities of human objects based on their motion trajectory analysis. In order to resolve the complexity and ambiguity problems caused by a large number of human objects, we propose a Group Interaction Zone (GIZ) to detect meaningful groups in a scene to effectively handle noisy information. Two novel features, Group Interaction Energy (GIE) feature and Attraction and Repulsion Features, are proposed to better describe group activities within a GIZ. We demonstrate the performance of our method in two ways by (i) comparing the performance of the proposed method with the previous methods and (ii) analyzing the influence of the proposed features and GIZ-based meaningful group detection on group activity recognition using public datasets.
Genetic Drift in Irradiated Experimental Populations of Drosophila Melanogaster.

HE investigation reported in the present paper is of the effects of genetic drift in three experimental populations of Drosophila melanogastar, two of which received treatments with gamma rays. Although there has been con-siderable theoretical discussion of genetic drift, few experimental studies of this phenomenon have been carried out. This paucity of experimental verifica-tion exists in spite of the fact that WRIGHT (1931 and other papers) has de-scribed several concrete situations where the effects of genetic drift could be studied and measured experimentally.
The Concept and the Epidemiology of Diabetic Nephropathy Have Changed in Recent Years

Diabetes Mellitus (DM) is a growing worldwide epidemic. It was estimated that more than 366 million people would be affected. DM has spread its presence over the world due to lifestyle changes, increasing obesity and ethnicities, among others. Diabetic nephropathy (DN) is one of the most important DM complications. A changing concept has been introduced from the classical DN to diabetic chronic kidney disease (DCKD), taking into account that histological kidney lesions may vary from the nodular or diffuse glomerulosclerosis to tubulointerstitial and/or vascular lesions. Recent data showed how primary and secondary prevention were the key to reduce cardiovascular episodes and improve life expectancy in diabetic patients. A stabilization in the rate of end stage kidney disease has been observed in some countries, probably due to the increased awareness by primary care physicians about the prognostic importance of chronic kidney disease (CKD), better control of blood pressure and glycaemia and the implementation of protocols and clinical practice recommendations about the detection, prevention and treatment of CKD in a coordinated and multidisciplinary management of the DM patient. Early detection of DM and DCKD is crucial to reduce morbidity, mortality and the social and economic impact of DM burden in this population.
Maternal Obesity in Early Pregnancy and Risk of Adverse Outcomes

Objectives To assess the role of the health consequences of maternal overweight and obesity at the start of pregnancy on gestational pathologies, delivery and newborn characteristics. Methods A cohort of pregnant women (n = 6.558) having delivered at the Maternal & Child University Hospital of Gran Canaria (HUMIGC) in 2008 has been studied. Outcomes were compared using multivariate analyses controlling for confounding variables. Results Compared to normoweight, overweight and obese women have greater risks of gestational diabetes mellitus (RR = 2.13 (95% CI: 1.52–2.98) and (RR = 2.85 (95% CI: 2.01–4.04), gestational hypertension (RR = 2.01 (95% CI: 1.27–3.19) and (RR = 4.79 (95% CI: 3.13–7.32) and preeclampsia (RR = 3.16 (95% CI: 1.12–8.91) and (RR = 8.80 (95% CI: 3.46–22.40). Obese women have also more frequently oligodramnios (RR = 2.02 (95% CI: 1.25–3.27), polyhydramnios. (RR = 1.76 (95% CI: 1.03–2.99), tearing (RR = 1.24 (95% CI: 1.05–1.46) and a lower risk of induced deliveries (RR = 0.83 (95% CI: 0.72–0.95). Both groups have more frequently caesarean section (RR = 1.36 (95% CI: 1.14–1.63) and (RR = 1.84 (95% CI: 1.53–2.22) and manual placenta extraction (RR = 1.65 (95% CI: 1.28–2.11) and (RR = 1.77 (95% CI: 1.35–2.33). Newborns from overweight and obese women have higher weight (p<0.001) and a greater risk of being macrosomic (RR = 2.00 (95% CI: 1.56–2.56) and (RR = 2.74 (95% CI: 2.12–3.54). Finally, neonates from obese mother have a higher risk of being admitted to special care units (RR = 1.34 (95% CI: 1.01–1.77). Apgar 1 min was significantly higher in newborns from normoweight mothers: 8.65 (95% CI: 8.62–8.69) than from overweight: 8.56 (95% CI: 8.50–8.61) or obese mothers: 8.48 (95% CI: 8.41–8.54). Conclusion Obesity and overweight status at the beginning of pregnancy increase the adverse outcomes of the pregnancy. It is important to promote the normalization of bodyweight in those women who intend to get pregnant and to provide appropriate advice to the obese women of the risks of obesity at the start of the pregnancy.
Pennogenin glycosides with a spirostanol structure are strong platelet agonists: structural requirement for activity and mode of platelet agonist synergism

Summary. Background: Steroidal saponins have long attracted scientific attention, due to their structural diversity and significant biological activities. For example, total steroidal saponins extracted from the rhizome of Paris polyphylla Sm. var. yunnanensis (TSSPs) constitute an effective treatment for abnormal uterine bleeding. Objective: To determine the active constituents in TSSPs and elucidate the mechanisms that underlie their in vivo pharmacologic actions on hemostasis. Methods: Steroidal saponins were purified by chromatography, and their effects upon hemostasis and platelet function were evaluated by tail bleeding time in mice and rats, aggregometry, flow cytometry and Western blotting. Results: TSSPs promoted hemostasis in vivo and dose‐dependently induced rat or human platelet aggregation in vitro. Using bioassay‐guided separation, four known pennogenin glycosides with a spirostanol structure were identified as the active ingredients of TSSPs. A structure–activity assay showed that the aglycone and sugar moieties of pennogenin glycosides are both essential for their aggregatory activity. Their synergistic actions on platelet aggregation were observed with pennogenin glycosides and with other known platelet agonists, suggesting that these glycosides are platelet agonists. Aggregation in response to the pennogenin glycosides involved αIIbβ3 activation, was inhibited by cAMP, was dependent upon extracellular calcium, secreted ADP and thromboxane synthesis, and was mediated by phosphatidylinositol‐3‐kinase. Conclusion: We identified pennogenin glycosides with a spirostanol structure as the active ingredients of Paris polyphylla Sm. var. yunnanensis in promoting hemostasis in vivo. Their mode of their action on platelets suggests that they represent a new type of platelet agonist.
Addressing the Changing Sources of Health Information in Iran

Background: Following the entrance of new technologies in health information era, this study aimed to assess changes in health information sources of Iranian people during past decade. Methods: Totally 3000 people were asked about their main sources of health information. They were selected as two community-based samples of 1500 people of more than 18-years-old in two different periods of time in August 2002 and August 2010 from the same locations in Tehran, the capital of Iran. Data analyzed based on age group, sex, educational level and household income in two different periods of time using Chi-square. Odds ratios associated with each basic characteristic were calculated using logistic regression. Results: Most common sources of health information in 2002 were radio and television (17.7%), caregivers (14.9%) and internet (14.2%) and in 2010 were radio and television (19.3%), internet (19.3%) and caregivers (15.8%) (P < 0.001). In 2010, young adults female used television and radio and male used internet as the main source of health information (P = 0.003). In moderate educational level women got their health information from radio and television and caregivers; while men used radio and television and internet as main source of health information (P = 0.005). Highly educated women and men mainly got their health information from internet and radio and television (P > 0.05). Conclusion: Although during 8 years of study radio and television remained as main source of health information but there is an increasing tendency to use internet especially in men. Policymakers should revise their broadcasting strategies based on people demand.
Component Behavior Near the Critical Point of the Random Graph Process

We study the behavior of a random graph process (G(n, M)):’ ) for M(n) = n12 + s and I ~ 1 ~ n ~ + m . Among others we find the number of components in G(n, M) and estimate the number of vertices and edges in the kth largest component of G(n, M), for any natural number k, Moreover, it is shown that, with probability 1 o(l), when M ( n ) = n12 + s, s 3 C 2 + -a, then during a random graph process in some step M’ > M a “new” largest component will emerge, ,whereas when s3n-*+m, the largest component of G(n, M) remains largest until the very end of the process.
Salmonella senftenberg epidemic in a neonatal nursery.

L'infection a frappe 7 nouveau-nes dont 5 presentaient des symptomes. Deux autres nouveau-nes symptomatiques ont ete infectes 4 et 9 mois apres le controle apparent de la maladie (la preuve de la difficulte de l'eradication complete de la maladie). Tous les cas symptomatiques presentaient une asphyxie grave a la naissance et 5 etaient hypotrophiques. Cinq nouveau-nes sont decedes. Les 2 nouveau-nes asymptomatiques etaient des prematures, non hypotrophique avec un Apgar normal
Learning to Read Words

The ease with which we process the written word belies its complexities and makes it easy to forget that it is a highly skilled behaviour and one that takes time to master. In this paper, I argue that our ability to read words has its roots in our capacity for language. Good progress has been made towards understanding how children discover the systematic relationship between speech sounds and the letters used to represents those sounds, very early in reading development. However, we understand much less about how beginning readers become skilled readers. To understand this, I argue that it is important to view the visual word recognition system within the context of a broader language system, one that incorporates a rich network of semantic and episodic knowledge.
Factors Affecting Distributed Agile Projects: a Systematic Review

In the last decade we have witnessed a growth in outsourcing and outshoring development. Following the promise of reducing costs and round-the-clock development, software organizations have grown from local to global enterprises. In the same decade, agile software development methodologies have emerged as a viable alternative to produce software. There is a myriad of agile processes and methodologies now available for any software development organization to choose from. These agile processes follow the values signed in the Agile Manifesto that preaches the exaltation of the individual programmer, high feedback, customer interaction and just enough planning and documentation. But how does global distribution affect these values? Can agile software development be implemented under the global software development context? This paper presents a systematic literature review aimed at identifying factors that affect the adoption of agile factors in global distributed teams. Our findings show that the literature is still in its initial case study publication stage. But most notably, we have found that only a few of the factors found are related to the agile values. Even though more research is clearly needed, this can be a signal that the factors affecting team distribution has more impact on software development than the values and practices preached by the agile processes.
Genetic structure of Kuwaiti population revealed by Y-STR diversity

In this study, a sample of 126 Kuwaiti was analysed using 12 Y-chromosome short tandem repeat (STR) polymorphisms. A total of 101 different haplotypes were identified, among which 87 were individual specific. The high haplotype diversity (0.994) supports the usefulness of Y-STR markers in Kuwaiti population diversity investigation. Our results suggest a close genetic relationship between Kuwait and other populations of the Arabian Peninsula, and an even more pronounced similarity of Kuwaiti populations and Yemenis and Saudi Arabians.
DominantMapper: Rule‐based analysis of SNP data for rapid mapping of dominant diseases in related nuclear families

With the advent of cheap rapid methods for whole‐genome SNP genotyping and the completion of the Human Genome Project, mapping disease loci has become primarily a bioinformatic rather than a laboratory problem. Here, we describe DominantMapper, a computer program that implements a rule‐based analysis algorithm for the detection of dominant disease loci in either a small number of nuclear families or a single large nuclear family. To demonstrate its utility, we present the successful analysis of two pedigrees in which the affected individuals carry either APC or TSPAN12 mutations. 32:1359–1366, 2011. ©2011 Wiley Periodicals, Inc.
Influence of compression sportswear on recovery and performance: A systematic review

Compression garments are becoming increasingly popular among sportspeople who wish to improve performance and reduce their exercise discomfort and risk of injury. However, evidence for such effects is scarce. This paper presents the evidence following a review of the literature evaluating the effects of the application of compression garments on sports performance and recovery after exercise. The literature reviewed was the result of a search on the Web of Science, PubMed, and SPORTDiscus electronic databases for studies which analysed the effect of compression garments on physiological, psychological, and biomechanical parameters during and after exercise. These search criteria were met by 40 studies. Most studies do not demonstrate any beneficial effect on performance, immediate recovery, or delay in the appearance of muscle pain. They do, however, show a positive trend towards a beneficial effect during recovery: the subsequent performance improved in five of the eight studies where it was measured, and the perception of muscle damage was reduced in five of six studies. In summary, the use of compression garments during recovery from exercise appears to be beneficial, although the factors explaining this efficacy have yet to be established. No adverse effects of the use of compression garments have been demonstrated.
CVS Filtering of 3D Turbulent Mixing Layers Using Orthogonal Wavelets

Coherent Vortex Simulation (CVS) filtering has been applied to Direct Numerical Simulation (DNS) data of forced and unforced time-developing turbulent mixing layers. CVS filtering splits the turbulent flow into two orthogonal parts, one corresponding to coherent vortices and the other to incoherent background flow. We have shown that the coherent vortices can be represented by few wavelet modes and that these modes are sufficient to reproduce the vorticity probability distribution function (PDF) and the energy spectrum over the entire inertial range. The remaining incoherent background flow is homogeneous, has small amplitude, and is uncorrelated. These results are compared with those obtained for the same compression rate using large eddy simulation (LES) filtering. In contrast to the incoherent background flow of CVS filtering, the LES subgrid scales have a much larger amplitude and are correlated, which makes their statistical modeling more difficult.
Mesenchymal Stem Cells Derived from Dental Pulp: A Review

The mesenchymal stem cells of dental pulp (DPSCs) were isolated and characterized for the first time more than a decade ago as highly clonogenic cells that were able to generate densely calcified colonies. Now, DPSCs are considered to have potential as stem cell source for orthopedic and oral maxillofacial reconstruction, and it has been suggested that they may have applications beyond the scope of the stomatognathic system. To date, most studies have shown that, regardless of their origin in third molars, incisors, or exfoliated deciduous teeth, DPSCs can generate mineralized tissue, an extracellular matrix and structures type dentin, periodontal ligament, and dental pulp, as well as other structures. Different groups worldwide have designed and evaluated new efficient protocols for the isolation, expansion, and maintenance of clinically safe human DPSCs in sufficient numbers for various therapeutics protocols and have discussed the most appropriate route of administration, the possible contraindications to their clinical use, and the parameters to be considered for monitoring their clinical efficacy and proper biological source. At present, DPSC-based therapy is promising but because most of the available evidence was obtained using nonhuman xenotransplants, it is not a mature technology.
Customizing Aspect-Oriented Variabilities using Generative Techniques

With the emergence of aspect-oriented (AO) techniques, crosscutting concerns can be now explicitly modularized and exposed as additional variabilities in program families. Hence, the development of highly customizable software family architectures requires the explicit handling of crosscutting variabilities through domain engineering and application engineering steps. In this context, this paper presents a generative model that addresses the implementation and instantiation of variabilities encountered in AO software family architectures. The use of our model allows for an early specification and preparation of AO variabilities, which in turn can be explicitly customized by means of domain engineering activities. All the variabilities of the architecture are modeled using feature models. In application engineering, developers can request an instance of the AO architecture in a process of two stages: (i) the definition of a feature model instance which specifies the resolution of variabilities for the AO family architecture; and (ii) the definition of a set of crosscutting relationships between features.