Miracle-dz/UniFAR-FTUs huggingface dataset:
The FIB-4 Index Predicts the Development of Liver-Related Events, Extrahepatic Cancers, and Coronary Vascular Disease in Patients with NAFLD

The prognosis of nonalcoholic fatty liver disease (NAFLD) patients depends on liver-related events (LREs), extrahepatic cancers, and major adverse cardiovascular events (MACEs). The fibrosis-4 (FIB-4) index is one of the most reliable and useful predictors of the degree of liver fibrosis. Recent studies have reported that the FIB-4 index is also useful for predicting LREs and MACEs in NAFLD patients. In the present study, we investigated the prognostic value of the FIB-4 index in NAFLD patients. A total of 506 biopsy-confirmed NAFLD patients from six hepatology centers in Japan from 2002 to 2013 were enrolled in this study. Of these NAFLD patients, 353 were available for more than 100 days of follow-up and did not exhibit events (LREs, extrahepatic cancers, MACEs) at the time of entry. The mean follow-up duration of all the subjects was 2716 ± 1621 days (102–7483 days). New LREs (hepatocellular carcinoma (HCC) (n = 8), decompensation (n = 11), bleeding varices (n = 8)) developed in 18 patients. Twenty-four and twelve patients developed extrahepatic cancers and MACEs, respectively. The median FIB-4 index was 1.255; we divided our cohort into two groups according to this (FIB4 Low, FIB4 Hi). The incidence of HCC tended to be higher in FIB4 Hi (n = 7) than in FIB4 Low (n = 1). The incidence of LREs was significantly higher in FIB4 Hi (n = 17) than in FIB4 Low (n = 1). The incidence of extrahepatic cancers was significantly higher in FIB4 Hi (n = 20) than in FIB4 Low (n = 4); the incidence of MACEs was also significantly higher in FIB4 Hi (n = 10) than in FIB4 Low (n = 2). The FIB-4 index is a useful biomarker for predicting not only LREs but also extrahepatic cancers and MACEs.
Relationships among Healthcare Providers’ Job Demands, Leisure Involvement, Emotional Exhaustion, and Leave Intention under the COVID-19 Pandemic

The COVID-19 pandemic has caused many medical issues. It has tested the impact of healthcare providers’ job demands, emotional exhaustion, and other pressures related to the impact on organizational leave intention. Accordingly, the purpose of this study was to verify the relationship between healthcare providers’ job demands, leisure involvement, emotional exhaustion, and leave intention under the COVID-19 pandemic. The questionnaire survey was used to address the issue of the present study. Convenience sampling was utilized to recruit 440 healthcare providers with a validity rate of 95%. Collected data were analyzed by structural equation modelling. Results indicated that healthcare providers’ job demands do not significantly influence leisure involvement. Job demands significantly influence emotional exhaustion. Job demands significantly influence leave intention. Emotional exhaustion significantly influences leave intention. Emotional exhaustion has a significant mediating effect between job demands and leave intention. Finally, relevant practical suggestions are provided based on the study results.
The Landscape of Gene Expression during Hyperfilamentous Biofilm Development in Oral Candida albicans Isolated from a Lung Cancer Patient

The filamentation ability of Candida albicans represents one of the main virulence factors allowing for host tissue penetration and biofilm formation. The aim of this paper was to study the genetic background of the hyperfilamentous biofilm development in vitro in C. albicans isolated from the oral cavity of a lung cancer patient. Analyzed C. albicans isolates (CA1, CA2, CA3) were chosen based on their different structures of mature biofilm. The CA3 isolate possessing hyperfilamentation properties and forming high biofilm was compared with CA1 and CA2 isolates exhibiting low or average biofilm-forming ability, respectively. The detailed biofilm organization was studied with the use of confocal scanning laser microscopy. The whole transcriptome analysis was conducted during three stages of biofilm development (24 h, 48 h, 72 h). In contrast to CA1 and/or CA2 isolate, the CA3 isolate was characterized by a significant upregulation of genes encoding for cell wall proteins (HWP1, PGA13, PGA44, ALS3) and candidalysin (ECE1), as well as being involved in iron metabolism (FRE1, ALS3), sulfur metabolism (HAL21), the degradation of aromatic compounds (HQD2), and membrane transport (DIP5, PHO89, TNA1). In contrast, some genes (SCW11, FGR41, RBE1) in the CA3 were downregulated. We also observed the overexpression of a few genes over time—mainly FRE1, ATX1, CSA2 involved in iron metabolism. This is the first insight into the potential function of multiple genes in the hyperfilamentous biofilm formation in C. albicans, primarily isolated from host tissue, which may have an important clinical impact on cancer patients. Moreover, the presented data can lay the foundation for further research on novel pathogen-specific targets for antifungal drugs.
Communication within families about advanced pediatric cancer: A qualitative study.

OBJECTIVES This qualitative study examined how families share information and feelings about advanced pediatric cancer from the perspective of both parents and children, as well as how these perspectives vary by child developmental stage. METHODS Participants (24 mothers, 20 fathers, 23 youth [children and adolescents]) were from a larger longitudinal study at an academic pediatric hospital. Eligible youth had advanced cancer (physician-estimated prognosis of <60%, relapse, or refractory disease), were aged 5-19 years (>8 years old to participate independently), had an English-speaking parent, and lived within 140 miles of the hospital. Interviews were completed at enrollment and asked how families share information and emotions about the child's cancer as a family. RESULTS Saturation was reached at 20 interviews for mothers, fathers, and youth. Analyses revealed 4 major themes: (A) parents managing cancer-related information based on child age/developmental stage and processing styles of family members; (B) parents withholding poor prognosis information and emotions to maintain positivity; (C) lack of personal and familial emotion sharing; and (D) emotion sharing among their family and externally. Both parents and youth endorsed themes A, C, and D, but only parents endorsed theme B. Adolescents endorsed more themes than children. Parents of children (as opposed to adolescents) endorsed theme A more. SIGNIFICANCE OF RESULTS Although both parents and youth with advanced cancer were generally willing to talk about treatment, emotions were not consistently shared. Perspectives varied depending on the child's developmental stage. Clinicians should assess parent and child information and emotion-sharing needs and provide individualized support to families regarding communication about advanced cancer.
Relationship between Partner Phubbing and Parent–Adolescent Relationship Quality: A Family-Based Study

A high-quality parent–child relationship is critical to the health and well-being of adolescents and, in the family system, the interaction pattern within couples is a decisive factor in parent–adolescent relationship quality. Using dyadic data from 441 Chinese couples, in this study, we examined the association between partner phubbing (a negative interaction behavior initiated by the spouse) and parent–adolescent relationship quality, and further explored the moderating effect of adolescent gender. Dyadic modeling showed that partner phubbing had both an intra-person effect and an inter-person effect on parent–adolescent relationship quality. For the intra-person effect, husbands’ phubbing had an adverse effect on the mother–adolescent relationship quality, and this effect was stronger for girls than boys; wives’ phubbing had a positive effect on the father–adolescent relationship quality, but this effect was only significant for boys. For the inter-person effect, the negative influence of husbands’ phubbing on father–adolescent relationship quality was only significant for boys; wives’ phubbing was uncorrelated with mother–adolescent relationship quality. These findings deepen our understanding of the links between the marital subsystem and the parent-adolescent subsystem in the family, underscore the importance of positive marital interactions for adolescent development, and have implications for personal smartphone use management in family contexts.
Traumatic Experiences in Childhood and Maternal Depressive Symptomatology: Their Impact on Parenting in Preschool

The goal of this study is to describe and analyze the relationship between childhood trauma and depressive symptoms and its relation to the parental interactions of mothers (19–47 years) with their 3–4 year old preschool children. Parental interactions, traumatic experiences in mothers’ childhood, and current depressive symptoms were measured using the Parenting Interactions with Children: Checklist of Observations Linked to Outcomes (PICCOLO), the Childhood Trauma Questionnaire Short Form (CTQ), and the Beck Depression Inventory (BDI-I), respectively. A nonclinical sample of 81 Chilean mothers with their children was used. Results show that the presence of trauma in mothers’ childhood has an impact on parenting; specifically, mothers with an emotional neglect experience showed greater difficulties in adequately promoting autonomy in their children.
An adaptive phase‐locked loop‐less control strategy for LCL‐filtered grid‐connected inverter under complex grid conditions

The phase‐locked loop, as a method to extract grid voltage phase angle, is commonly used for grid‐connected inverter to synchronize the injected grid current with the grid. However, the phase‐locked loop will also bring some problems. The current loop controller, the phase‐locked loop, and the grid impedance are coupled together under the weak grid. Then, the phase angle of the inverter output impedance will be reduced, causing the system to be unstable. Moreover, the output phase angle of the phase‐locked loop participates in the coordinate transformation under the unbalanced grid voltage condition, which degrades the quality of the injected grid current generated by the inverter with high harmonic content. Therefore, a vector current control strategy without phase‐locked loop derived from direct power control is used in this paper. An adaptive linear Kalman filter algorithm is also applied to observe the voltage information and avoid the harmonic problems caused by power calculation. Finally, simulations and experiments are conducted to verify that the proposed method is effective, and the results are consistent with the theoretical analysis.
An integrated fault diagnosis and safe‐parking framework for fault‐tolerant control of nonlinear systems

In this work, we consider the problem of designing an integrated fault diagnosis and fault‐handling framework to deal with actuator faults in nonlinear systems. A model‐based fault diagnosis design is first proposed, which can not only identify the failed actuator but also estimate the fault magnitude. The fault information is obtained by estimating the outputs of the actuators and comparing them with the corresponding prescribed control inputs. This methodology is developed under state feedback control and generalized to deal with state estimation errors. Then the safe‐parking framework developed previously (to handle the case where the failed actuator reverts to a known fixed value) for fault‐tolerant control is extended to handle the case where an actuator seizes at an arbitrary value. The estimate of the failed actuator position provided by the fault diagnosis design is used to choose a safe‐park point, at which the system operates temporarily during fault repair, from those generated offline for a series of design values of the failed actuator position. The discrepancy between the actual value of the failed actuator position and the corresponding design value is handled through the robustness of the control design. The efficacy of the integrated fault diagnosis and safe‐parking framework is demonstrated through a chemical reactor example. Copyright © 2011 John Wiley & Sons, Ltd.
Assessment of tourism service quality for traditional craft villages in Da Nang city, Vietnam

Abstract Traditional craft villages are becoming more popular as cultural tourism destinations since they preserve and represent indigenous people’s culture and lifestyles while also contributing significantly to the economy. Along with the current surge in visitors, traditional villages must improve service quality components to strengthen their attractiveness and competitiveness. To analyze the quality of tourism services given by the places, the study was done in Da Nang, a city in Vietnam’s central region with various unique traditional craft villages. In this study, the research paradigm “Importance—Performance Analysis” (IPA) was used and converted with “SERVQUAL. ” A total of 120 tourists who had previously visited Da Nang’s traditional craft villages were surveyed. The findings suggest that tourists place a high value on indices showing the importance of tourism service quality, but they undervalue performance. Overall, the article advises and proposes four group solutions based on priority levels in order to improve and further expand the quality of services in traditional craft villages in Da Nang city.
Identification of MYB Transcription Factors Involving in Fruit Quality Regulation of Fragaria × ananassa Duch.

The cultivated strawberry (Fragaria × ananassa Duch.) is an important horticultural crop. The economic values of strawberry cultivars are decided by their fruit qualities including taste, color and aroma. The important role of MYB transcription factors in fruit quality regulation is recognized increasingly with the identification of MYB genes involved in metabolism. A total of 407 MYB genes of F. × ananassa (FaMYBs) were identified in the genome-wide scale and named according to subgenome locations. The 407 FaMYBs were clustered into 36 groups based on phylogenetic analysis. According to synteny analysis, whole genome duplication and segmental duplication contributed over 90% of the expansion of the FaMYBs family. A total of 101 FaMYB loci with 1–6 alleles were identified by the homologous gene groups on homologous chromosomes. The differentially expressed FaMYB profiles of three cultivars with different fruit quality and fruit ripe processes provided the 8 candidate loci involved in fruit quality regulation. In this experiment, 7, 5, and 4 FaMYBs were screeded as candidate genes involved in the regulation of metabolism/transportation of anthocyanins, sugars or organic acids and 4-hydroxy-2, 5-dimethyl-3(2H)-furanone, respectively. These results pointed out the key FaMYBs for further functional analysis of gene regulation of strawberry fruit quality and would be helpful in the clarification on ofe roles of MYBs in the metabolism of fruit crops.
Time Duration of Post-Activation Performance Enhancement (PAPE) in Elite Male Sprinters with Different Strength Levels

(1) Purpose: This study aimed to explore the time duration of post-activation performance enhancement (PAPE) in elite male sprinters with different strength levels. (2) Methods: Thirteen elite male sprinters were divided into a strong group (relative strength: 1RM squat normalized by body mass of ≥2.5; n = 6) and a weak group (relative strength of <2.5; n = 7). All sprinters performed one static squat jump (SSJ) at baseline and 15 s, 3 min, 6 min, 9 min, and 12 min following an exercise protocol including three reps of a 90% 1RM back squat. Two force plates were used to determine the vertical jump height, the impulse output, and the power output for all SSJs. (3) Results: Significant improvements in vertical jump height and peak impulse were observed (p < 0.05) at 3, 6, and 9 min, without significant between-group differences. The peak power had a significant increase in 3 min (p < 0.01) and 6 min (p < 0.05), with also no significant difference between-group differences. Moreover, the stronger subjects induced a greater PAPE effect than the weaker counterparts at 3, 6, and 9 min after the intervention. The maximal benefit following the intervention occurred at 6 min and 3 min after the intervention in the stronger and weaker subjects, respectively. (4) Conclusions: The findings indicated that three reps of a 90% 1RM back squat augmented the subsequent explosive movement (SSJ) for 3–9 min in elite male sprinters, especially in stronger sprinters.
A search for photometric variability of hydrogen-deficient planetary-nebula nuclei

Aims. We searched for photometric variability in a sample of hot, hydrogen-deficient planetary nebula nuclei (PNNi) with “PG 1159” or “O VI” spectral type, most of them embedded in a bipolar or elliptical planetary nebula envelope (PNe). These characteristics may indicate the presence of a hidden close companion and an evolution affected by episodes of interaction between them. Methods. We obtained time-series photometry from a sample of 11 candidates using the Nordic Optical Telescope (NOT) with the Andalucia Faint Object Spectrograph and Camera (ALFOSC), modified with our own control software to be able to observe in a high-speed multi-windowing mode. The data were reduced on-line with the real time photometry (RTP) code, which allowed us to detect periodic variable stars with small amplitudes from CCD data in real time. We studied the properties of the observed modulation frequencies to investigate their nature. Results. We report the first detection of low-amplitude pulsations in the PNNi VV 47, NGC 6852, and Jn 1. In addition, we investigated the photometric variability of NGC 246. Time-series analysis shows that the power spectra of VV 47, NGC 6852, and NGC 246 are variable on time scales of hours. Power spectra from consecutive nights of VV 47 and NGC 6852 show significant peaks in different frequency regions. The same type of variability is present in NGC 246 in 2 observing runs separated by 3 days. Changes are also found in the power spectra of VV 47 and NGC 246 during the same night. The VV 47 power spectra are peculiar since they present modulation frequencies in a wide range from 175 to 7600 μ Hz. This is different from the previously known pulsating PNNi where no frequencies are found above ~3000 μ Hz. The high-frequency modulation observed in VV 47 may be due to g -modes triggered by the ϵ -mechanism, observed for the first time.
Understanding the subjective experiences of memory concern and MCI diagnosis: A scoping review

Introduction Many older people experience memory concerns; a minority receive a diagnosis of Mild Cognitive Impairment (MCI) or Subjective Cognitive decline (SCD). There are concerns that medicalisation of MCI and memory concern may fail to acknowledge subjective experiences. Aim We explore the meaning individuals give to their memory concerns, with or without a diagnosis of MCI and SCD. Method We scoped literature exploring subjective experiences of memory concern, with or without a diagnosis of MCI or SCD. We searched CINAHL, PsycINFO and MEDLINE in March 2020, and updated in Sept 2021.We used (Arksey & O’Malley, 2005) framework to guide our scoping review method and thematic analysis to analyse our findings. Results We screened 12,033 search results reviewing the full texts of 92 papers. We included 24 papers, including a total of 453 participants, the majority of whom were female, from White ethnic majority populations (or from studies where ethnicity was not identified) with high levels of education. In 15 out of 24 studies, 272 participants were diagnosed with MCI. We identified two themes; Making a diagnosis personal and Remembering not to forget. We found that subjective experiences include normative comparison with others of the same age and responses including fear, relief, and acceptance, but culminating in uncertainty. Conclusion Drawing upon sociology, we highlight the subjective experiences of living with memory concerns, SCD and an MCI diagnosis. We identify a gap between the intended purpose of diagnostic labels to bring understanding and certainty and the lived experiences of those ascribed them.
Modern Developments in Bifunctional Chelator Design for Gallium Radiopharmaceuticals

The positron-emitting radionuclide gallium-68 has become increasingly utilised in both preclinical and clinical settings with positron emission tomography (PET). The synthesis of radiochemically pure gallium-68 radiopharmaceuticals relies on careful consideration of the coordination chemistry. The short half-life of 68 min necessitates rapid quantitative radiolabelling (≤10 min). Desirable radiolabelling conditions include near-neutral pH, ambient temperatures, and low chelator concentrations to achieve the desired apparent molar activity. This review presents a broad overview of the requirements of an efficient bifunctional chelator in relation to the aqueous coordination chemistry of gallium. Developments in bifunctional chelator design and application are then presented and grouped according to eight categories of bifunctional chelator: the macrocyclic chelators DOTA and TACN; the acyclic HBED, pyridinecarboxylates, siderophores, tris(hydroxypyridinones), and DTPA; and the mesocyclic diazepines.
Macrophages Release Extracellular Vesicles of Different Properties and Composition Following Exposure to Nanoparticles

Extracellular vesicles are membrane-bound carriers with complex cargoes, which play a major role in intercellular communication, for instance, in the context of the immune response. Macrophages are known to release extracellular vesicles in response to different stimuli, and changes in their size, number, and composition may provide important insights into the responses induced. Macrophages are also known to be highly efficient in clearing nanoparticles, when in contact with them, and in triggering the immune system. However, little is known about how the nature and composition of the vesicles released by these cells may vary upon nanoparticle exposure. In order to study this, in this work, alveolar-like macrophages were exposed to a panel of nanoparticles with varying surface and composition, including amino-modified and carboxylated polystyrene and plain silica. We previously showed that these nanoparticles induced very different responses in these cells. Here, experimental conditions were carefully tuned in order to separate the extracellular vesicles released by the macrophages several hours after exposure to sub-toxic concentrations of the same nanoparticles. After separation, different methods, including high-sensitivity flow cytometry, TEM imaging, Western blotting, and nanoparticle tracking analysis, were combined in order to characterize the extracellular vesicles. Finally, proteomics was used to determine their composition and how it varied upon exposure to the different nanoparticles. Our results show that depending on the nanoparticles’ properties. The macrophages produced extracellular vesicles of varying number, size, and protein composition. This indicates that macrophages release specific signals in response to nanoparticles and overall suggests that extracellular vesicles can reflect subtle responses to nanoparticles and nanoparticle impact on intercellular communication.