Miracle-dz/UniFAR-FTUs huggingface dataset:
Nuclear retention of all steroid hormone receptor classes in the hamster renal carcinoma.

The estrogen-induced hamster renal carcinoma contains appreciable amounts of all cytosolic steroid receptor classes sedimenting as 7 to 8S moieties following sucrose gradient centrifugation. Their relative concentrations, expressed in fmol/mg protein +/- S.E. are progesterone (1496 +/- 23) greater than estradiol (218 +/- 3) greater than 5 alpha-dihydrotestosterone (154 +/- 7) greater than dexamethasone (138 +/- 3) greater than aldosterone (40 +/- 2). No cross-competition is apparent for either estrogen or progesterone receptors, but progesterone competes for both androgen and adrenocorticoid binding. These hormone-receptor complexes undergo nuclear translocation using purified tumor nuclei and in tissue minces at elevated temperatures. Salt-extractable nuclear receptors for estrogen (5S), androgen (3.2S), progesterone (2.7S), and corticosteroid (3.5S) have been identified. The existence of five specific steroid receptors within a single tissue is unique and provides a novel model for studying the interrelated actions of all steroid hormones and their therapeutic responses in a hormone-dependent neoplasm.
A Bandwidth-Saving Optimization for MPI Broadcast Collective Operation

The efficiency and scalability of MPI collective operations, in particular the broadcast operation, plays an integral part in high performance computing applications. MPICH, as one of the contemporary widely-used MPI software stacks, implements the broadcast operation based on point-to-point operation. Depending on the parameters, such as message size and process count, the library chooses to use different algorithms, as for instance binomial dissemination, recursive-doubling exchange or ring all-to-all broadcast (all-gather). However, the existing broadcast design in latest release of MPICH does not provide good performance for large messages (lmsg) or medium messages with non-power-of-two process counts (mmsg-npof2) due to the inner suboptimal ring allgather algorithm. In this paper, based on the native broadcast design in MPICH, we propose a tuned broadcast approach with bandwidth-saving in mind catering to the case of lmsg and mmsg-npof2. Several comparisons of the native and tuned broadcast designs are made for different data sizes and program sizes on Cray XC40 cluster. The results show that the performance of the tuned broadcast design can get improved by a range from 2% to 54% for lmsg and mmsg-npof2 in terms of user-level testing.
Revue générale Microchimérisme fœtal : un bien ou un mal pour le fœtus et sa mère ? Is fetal microchimerism beneficial for the fetus or the mother ?

There is a two-way traffic of cells through the placenta during the pregnancy (feta and maternal microchimerisms). Fetal cells migrate in the maternal body where they are present long after birth. The fetal microchimerism may be deleterious for the mother when implicated in the induction of autoimmune diseases and of repeated abortion. Usually fetal microchimerism is beneficial for the mothers. Fetal cells can repair damaged tissues, transmit paternal resistance alleles, improve the directory of T cell receptors. In cancer, the effects are more contrasted, beneficial and protective for certain cancers, harmful and favouring the development for the others. The phenomenon of fetal and maternal microchimerisms inspires numerous questions and offers new perspectives on the biology of pregnancy and cancer, on pathogenesis of auto-immunity, of the transplantations, without forgetting the biology of the heredity because these cells could bring resistance or risk alleles for some diseases from the father towards the mother through the fetus, through the mother to the fetus, from the first fetus of a first pregnancy to the next fetus through the woman. 2011 Elsevier Masson SAS. All rights reserved. * Auteur correspondant. Adresses e-mail : denis.vinatier@chru-lille.fr, dvinatier@wanadoo.fr
Water repellent efficiency of wood treated with copper-azole combined with silicone and paraffin emulsions

Copper-azole free of chromium and arsenic is one of the potential wood preservatives against wood decay organisms being on the market as an alternative to CCA (copper, chrome, arsenic). In this study, copper-azole solution with the concentration of 2.4 % was mixed with water repellents, 0.5 %, 1 % and 2 % of silicon emulsions as well as 5, 10 and 15% of paraffin emulsions respectively. In the first experiment Scots pine samples were treated with these solutions followed by a fixation step in a conditioned chamber (21°C , 65% RH). In the second experiment, treatment of the Scots pine specimens was done with the same formulations, but the samples were dried in an oven at 100 °C for two days in order to measure water absorption and water repellency efficiency. Paraffin emulsions reduced the water absorption more than copper-azole alone and silicon based formulations when the samples left the fixation in the conditioning chamber. Water absorption increased in the samples dried at 100 °C compared to those left to ambient condition. The oven drying increased the water absorption to the copper-azole treated wood. Paraffin emulsions lead to better water repellency compared to control and silicon emulsions, but the increasing in the paraffin emulsion did not improved the efficiency.
Silent Information Regulator 1 Protects the Heart From Ischemia/Reperfusion

Background— Silent information regulator 1 (Sirt1), a class III histone deacetylase, retards aging and protects the heart from oxidative stress. We here examined whether Sirt1 is protective against myocardial ischemia/reperfusion (I/R). Methods and Results— Protein and mRNA expression of Sirt1 is significantly reduced by I/R. Cardiac-specific Sirt1−/− mice exhibited a significant increase (44±5% versus 15±5%; P=0.01) in the size of myocardial infarction/area at risk. In transgenic mice with cardiac-specific overexpression of Sirt1, both myocardial infarction/area at risk (15±4% versus 36±8%; P=0.004) and terminal deoxynucleotidyl transferase dUTP nick end labeling-positive nuclei (4±3% versus 10±1%; P<0.003) were significantly reduced compared with nontransgenic mice. In Langendorff-perfused hearts, the functional recovery during reperfusion was significantly greater in transgenic mice with cardiac-specific overexpression of Sirt1 than in nontransgenic mice. Sirt1 positively regulates expression of prosurvival molecules, including manganese superoxide dismutase, thioredoxin-1, and Bcl-xL, whereas it negatively regulates the proapoptotic molecules Bax and cleaved caspase-3. The level of oxidative stress after I/R, as evaluated by anti-8-hydroxydeoxyguanosine staining, was negatively regulated by Sirt1. Sirt1 stimulates the transcriptional activity of FoxO1, which in turn plays an essential role in mediating Sirt1-induced upregulation of manganese superoxide dismutase and suppression of oxidative stress in cardiac myocytes. Sirt1 plays an important role in mediating I/R-induced increases in the nuclear localization of FoxO1 in vivo. Conclusions— These results suggest that Sirt1 protects the heart from I/R injury through upregulation of antioxidants and downregulation of proapoptotic molecules through activation of FoxO and decreases in oxidative stress.
The Involvement of miR-29b-3p in Arterial Calcification by Targeting Matrix Metalloproteinase-2

Vascular calcification is a risk predictor and common pathological change in cardiovascular diseases that are associated with elastin degradation and phenotypic transformation of vascular smooth muscle cells via gelatinase matrix metalloproteinase-2 (MMP2). However, the mechanisms involved in this process remain unclear. In this study, we investigated the relationships between miR-29b-3p and MMP2, to confirm miR-29b-3p-mediated MMP2 expression at the posttranscriptional level in arterial calcification. In male Sprague Dawley rats, arterial calcification was induced by subcutaneous injection of a toxic dose of cholecalciferol. In vivo, the quantitative real-time polymerase chain reaction (qRT-PCR) showed that MMP2 expression was upregulated in calcified arterial tissues, and miR-29b-3p expression was downregulated. There was a negative correlation between MMP2 mRNA expression and miR-29b-3p levels (P = 0.0014, R2 = 0.481). Western blotting showed that MMP2 expression was significantly increased in rats treated with cholecalciferol. In vitro, overexpression of miR-29b-3p led to decreased MMP2 expression in rat vascular smooth muscle cells, while downregulation of miR-29b-3p expression led to increased MMP2 expression. Moreover, the luciferase reporter assay confirmed that MMP2 is the direct target of miR-29b-3p. Together, our results demonstrated that a role of miR-29b-3p in vascular calcification involves targeting MMP2.
A Framework for motion-based mesh sequence segmentation

In this paper, we present a complete framework to produce motion-based geometric segmentation of mesh sequences: each segment corresponds to a mesh region that tends either to move rigidly, or to be stretched in a uniform way. We take a sequence of meshes with varying number of vertices as input and match them by pairs. This allows us to ﬁnd the approximated displacement vector of each vertex of the ﬁrst frame all along the sequence. Using these displacement vectors, an initial segmentation is performed on the ﬁrst pair of frames, clustering vertices into static, stretched and rigidly moving regions. This segmentation is then reﬁned after each matching. Our segmentation is computed on the ﬂy, and lets us ﬁnd the exact frame when each transformation (rotation, translation, stretch) appears. We have validated our method both on dynamic meshes and unconstrained mesh sequences.
Linking Past to Present: Discovering Style in Two Centuries of Architecture

With vast quantities of imagery now available online, researchers have begun to explore whether visual patterns can be discovered automatically. Here we consider the particular domain of architecture, using huge collections of street-level imagery to find visual patterns that correspond to semantic-level architectural elements distinctive to particular time periods. We use this analysis both to date buildings, as well as to discover how functionally-similar architectural elements (e.g. windows, doors, balconies, etc.) have changed over time due to evolving styles. We validate the methods by combining a large dataset of nearly 150,000 Google Street View images from Paris with a cadastre map to infer approximate construction date for each facade. Not only could our analysis be used for dating or geo- localizing buildings based on architectural features, but it also could give architects and historians new tools for confirming known theories or even discovering new ones.
Transcriptional Activation of Stress Genes and Cytotoxicity in Human Liver Carcinoma (HepG2) Cells Exposed to Pentachlorophenol

Abstract: Pentachlorophenol (PCP) is a biocidal chemical with several industrial, agricultural, and domestic applications. There is accumulating evidence indicating that PCP is highly toxic to humans, with major target organs including the lung, liver, kidneys, heart, and brain. Little is known regarding the molecular basis by which PCP induces toxicity, mutagenesis, and carcinogenesis. Therefore, this research was designed to assess the cellular and molecular responses of HepG 2 cells following exposure to PCP. The cytotoxicity experiment yielded a LD 50 value of 23.4 + 9.7 µg PCP/mL upon 48 hrs of exposure, indicating that PCP is acutely toxic. A dose-response relationship was recorded with respect to gene induction. For example, fold inductions of CYP1A1 were 1.0 + 0.0, 1.0 + 0.0, 1.3 + 0.5, 6.3 + 4.3, and 22.5 + 3.5 for 0, 6.2, 12.5, 25, and 50 µg PCP/mL, respectively. Overall, five out of the thirteen recombinant cell lines tested showed inductions to statistically significant levels (
Mixed Precision Method for GPU-based FFT

In order to solve the low accuracy problem of GPU-based FFT, a mixed precision method is employed in this paper. A "precision cache" method is proposed as the supplement of the mixed precision method to calculate of twiddle factor. A work group split method is used to reduce the latency of access global memory frequently. The mixed precision FFT achieves 3 times accuracy improvement compared to CUFFT3.2 and 4 times peak performance to MKL FFT. The experiment shows that mixed precision method on CPU-GPU heterogeneous platform achieves high accuracy and efficient Fast Fourier Transform.
You Want Me To Do What? A Design Study of Two-Factor Authentication Messages

Security messages that ask users to adopt new behaviors can be a crucial aspect of users’ security decision-making. Prior work has focused extensively on how to design warning messages to discourage insecure practices. In this work, we instead examine how to design motivating security messages to encourage adoption, taking two-factor authentication (2FA) as a case study. To this end, we conduct an interview and participatory design study with 12 demographically diverse participants. Participants both critiqued existing 2FA messages and designed new ones. Drawing from the results of these interviews, we extract preliminary design options for authentication tool messages, which we plan to validate in future work.
A new semi-empirical method based on a distorted tetragonal scheme for the structure prediction and alloy design of multiple-component alloys

High Entropy Alloys (HEA) are many-component (>4), near equiatomic compositions that by definition, forms disordered single phases, but are also known to form ordered phases such as C14 Laves, B2, Sigma etc. Understanding of the HEA phase stability is limited due to lack of knowledge of HEA thermodynamics as their stoichiometry is located at, or near the centre of their corresponding phase diagrams. Utilising HEAs in industrial and/or functional applications requires this understanding for successful design of HEA compositions. The original contribution of this thesis is the development of a simple, semi-empirical model that allows the prediction of some HEA properties (relative phase stability, hardness) that can be easily implemented. The model is developed through initial analysis of HEAs exploring the influence of the electronic density on phase stability utilising the Thomas-Fermi-Dirac equation for constrained neutral atoms; and the influence of a possible reduction in valence orbital degeneracy due to the breaking of symmetry from changes in phase. The hypotheses formed from this analysis are further compared with robust ab-initio calculations following the Rigid Band Approximation within Density Functional theory. The final two chapters examine the construction of the proposed model and its refinement; experimental validation of the model is performed through an engineering of a possible replacement for the Stellite family of Co-Cr alloys, which has been optimised for wear resistance. Experimental validation shows good results with respect to the predicted values.
A Novel Top-K Automobiles Probabilistic Recommendation Model Using User Preference and User Community

The economic level rising and the rapid development of automobile industry offers various opinions for buyers. The automobile dealers provide services to users by recommending popular and fashionable automobiles. However, few of them offer the personalized recommendation services online. In this paper, we propose an automobile recommendation system to recommend top-K ranked automobiles for users. We first propose a model to analyze the individual requirements and user community which may affect the user's purchase behaviors. And then we develop an estimation algorithm to compute the parameters in proposed model. With the trained model, we conduct the personalized recommendation algorithm using model parameters. Experiments with real-life data sets confirms the effectiveness and scalability of our algorithms.
Asymmetric exclusion model and weighted lattice paths

We show that the known matrix representations of the stationary state algebra of the asymmetric simple exclusion process (ASEP) can be interpreted combinatorially as various weighted lattice paths. This interpretation enables us to use the constant term method (CTM) and bijective combinatorial methods to express many forms of the ASEP normalization factor in terms of ballot numbers. One particular lattice path representation shows that the coefficients in the recurrence relation for the ASEP correlation functions are also ballot numbers. Additionally, the CTM has a strong combinatorial connection which leads to a new 'canonical' lattice path representation and to the 'ω-expansion' which provides a uniform approach to computing the asymptotic behaviour in the various phases of the ASEP. The path representations enable the ASEP normalization factor to be seen as the partition function of a more general polymer chain model having a two-parameter interaction with a surface.We show, in the case α = β = 1, that the probability of finding a given number of particles in the stationary state can be expressed via non-intersecting lattice paths and hence as a simple determinant.
A Phase II, Double-Blind, Placebo-Controlled, Ascending-Dose Study of Eritoran (E5564), a Lipid A Antagonist, in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass

BACKGROUND: Lipid A, the toxic moiety of endotoxin, is linked to multiple complications after cardiac surgery, including fever, vasodilation, and pulmonary and renal dysfunction. The lipid A antagonist eritoran (or E5564) prevents endotoxin-induced systemic inflammation in animals and humans. In this study we assessed the safety of eritoran administration in patients undergoing cardiac surgery and obtained preliminary efficacy data for the prophylaxis of endotoxin-mediated surgical complications. METHODS: A double-blind, randomized, ascending-dose, placebo-controlled study was conducted at nine hospitals. Patients undergoing coronary artery bypass graft and/or cardiac valvular surgery with cardiopulmonary bypass were enrolled. Patients received a 4-h infusion of placebo (n = 78) vs 2 mg (n = 24), 12 mg (n = 26), or 28 mg (n = 24) of eritoran initiated approximately 1 h before cardiopulmonary bypass. RESULTS: No significant safety concerns were identified with continuous safety monitoring, and enrollment continued to the highest prespecified dose (28 mg). No statistically significant differences were observed in most variables related to systemic inflammation or organ dysfunction/injury. CONCLUSIONS: This Phase II safety study suggests that the administration of the novel lipid A antagonist, eritoran, is not associated with overt toxicity in cardiac surgical patients. Blocking lipid A with eritoran does not appear to confer any clear benefit to elective cardiac surgical patients.
Autonomous aerial refueling based on the tanker reference frame

An aircraft formation autopilot is designed for flight test to demonstrate autonomous aerial refueling. The controller requirements are stated, and models for the lead and wing aircraft are outlined and stabilized. Control laws are developed for the model, and four frames of reference are investigated for optimal control. Next, a simulation is constructed with modeled disturbances to produce the real-time inputs that will be available to the controller. Results from simulations of the controller are presented and assessed, including an exploration of sensitivity and robustness. Finally, results are presented from a limited flight test investigation conducted with a formation of an Air Force C-12 and a variable stability Learjet LJ-25, flown by the controller. Fully autonomous aerial refueling maneuvers were successfully demonstrated in both level and turning flight. Finally, conclusions and lessons learned from the flight test and the controller development are presented
Standards Related to Prognostics and Health Management (PHM) for Manufacturing

Prognostics and health management (PHM) technologies reduce burdensome maintenance tasks of products or processes through diagnostic and prognostic activities. These activities provide actionable information that enable intelligent decision‐making for improved performance, safety, reliability, and maintainability. However, standards for PHM system development, data collection and analysis techniques, data management, system training, and software interoperability appear to be partly lacking. The National Institute of Standards and Technology1 (NIST) conducted a survey of PHM‐related standards to determine the industries and needs addressed by such standards, the extent of these standards, and any similarities as well as potential gaps among the documents. Standards from various national and international organizations are summarized, including those from the Air Transport Association (ATA), the International Electrotechnical Commission (IEC), the International Organization for Standardization (ISO), the Society of Automotive Engineers (SAE), and the United States Army (US Army). Finally, recommendations are offered for the development of future PHM‐related standards.
AS-Aware Relay Selection Using DHT Service Discovery in P2P Overlays

Application relay is important for many delay-sensitive applications such as Voice over Internet Protocol (VoIP). It has been proved that relay selection would be optimized considering Autonomous Domains (ASes) relationship. We describe a new method for relay selection using service discovery in Distributed Hash Table(DHT) in which relay service advertisements are indexed and clustered according to AS. Advertisement and discovery mechanism is designed in detail. Evaluation and simulation analyze the performance of our method.
Waterpipe Use Predicts Progression to Regular Cigarette Smoking Among Danish Youth

Waterpipe smoking among Danish, Swedish, and German youth is increasing dramatically, indicating the emergence of a new health threat. This study assessed the association between waterpipe smoking and progression to regular cigarette smoking among Danish continuation school students during 2004–2005. All participants (N = 762) had smoked cigarettes on a nonregular basis at baseline. Among boys, waterpipe smoking frequency was predictive of being a regular cigarette smoker at follow-up eight months later. Further research should examine waterpipe smoking as a potential predictor of cigarette smoking. The study's limitations are noted.
Upgrades, Upsells and Pricing in Revenue Management

Capacity providers often experience a mismatch between supply and demand that can be partially alleviated while improving revenues by allowing for product upgrades. When prices are fixed and demands are independent, the problem is to decide which customer demands to upgrade to which products and when. We show that a fairness constraint can be imposed without loss of optimality under mild conditions. We also investigate a model that limits upgrades to the next higher quality product, and we provide necessary and sufficient conditions for its revenues to be as high as that of any less restricted upgrade model. Resellers of capacity also have an incentive to use upgrades as a mechanism to entice customers to higher quality products with higher commission margins. We show that this practice can be very profitable and that the profits can be much larger than direct commissions from sales would indicate. We then investigate the case where sellers have pricing flexibility and customer demand is driven by a choice model. We derive pricing formulas under the assumption that demand for products follows a multinomial logit model, and we develop an algorithm for finding a global optimal solution to the capacity constrained profit function. For this model we show that neither upgrades nor upsells improve profits when margins are homogenous and there is complete freedom in selecting prices. However, upgrades can improve revenues significantly when sensible business constraints on prices are imposed and when margins are heterogenous.