Miracle-dz/UniFAR-FTUs huggingface dataset:
NMR structural studies of the ionizing radiation adduct 7-hydro-8-oxodeoxyguanosine (8-oxo-7H-dG) opposite deoxyadenosine in a DNA duplex. 8-Oxo-7H-dG(syn).dA(anti) alignment at lesion site.

Proton NMR studies are reported on the complementary d(C1-C2-A3-C4-T5-A6-oxo-G7-T8-C9-A10-C11-C12). d(G13-G14-T15- G16-A17-A18-T19- A20-G21-T22-G23-G24) dodecanucleotide duplex (designated 8-oxo-7H-dG.dA 12-mer), which contains a centrally located 7-hydro-8-oxodeoxyguanosine (8-oxo-7H-dG) residue, a group commonly found in DNA that has been exposed to ionizing radiation or oxidizing free radicals. From the NMR spectra it can be deduced that this moiety exists as two tautomers, or gives rise to two DNA conformations, that are in equilibrium and that exchange slowly. The present study focuses on the major component of the equilibrium that originates in the 6,8-dioxo tautomer of 8-oxo-7H-dG. We have assigned the exchangeable NH1, NH7, and NH2-2 base protons located on the Watson-Crick and Hoogsteen edges of 8-oxo-7H-dG7 in the 8-oxo-7H-dG.dA 12-mer duplex, using an analysis of one- and two-dimensional nuclear Overhauser enhancement (NOE) data in H2O solution. The observed NOEs derived from the NH7 proton of 8-oxo-7H-dG7 to the H2 and NH2-6 protons of dA18 establish an 8-oxo-7H-dG7(syn). dA 18(anti) alignment at the lesion site in the 8-oxo-7H-dG.dA 12-mer duplex in solution. This alignment, which places the 8-oxo group in the minor groove, was further characterized by an analysis of the NOESY spectrum of the 8-oxo-7H-dG.dA 12-mer duplex in D2O solution. We were able to detect a set of intra- and interstrand NOEs between protons (exchangeable and nonexchangeable) on adjacent residues in the d(A6-oxo-G7-T8). d(A17-A18-T19) trinucleotide segment centered about the lesion site that establishes stacking of the oxo-dG7(syn). dA(anti) pair between stable Watson-Crick dA6.dT19 and dT8.dA17 base pairs with minimal perturbation of the helix. Thus, both strands of the 8-oxo-7H-dG.dA 12-mer duplex adopt right-handed conformations at and adjacent to the lesion site, the unmodified bases adopt anti glycosidic torsion angles, and the bases are stacked into the helix. The energy-minimized conformation of the central d(A6-oxo-G7-T8). d(A17-A18-T19) segment requires that the 8-oxo-7H-dG7(syn). dA18(anti) alignment be stabilized by two hydrogen bonds from NH7 and O6 of 8-oxo-7H-dG7(syn) to N1 and NH2-6 of dA18(anti), respectively, at the lesion site. (ABSTRACT TRUNCATED AT 400 WORDS)
Social Studies on the Back Burner: Views from the Field.

Elementary social studies is “on the back burner. ” Heavy competition for resources, low student interest and teacher concern, and a highly sanitized and uneven curriculum are among the conditions underlying its under representation. Among the various effects of this back burner status, limited opportunity for substantive social development is perhaps the most important. Moving social studies to the forefront of the curriculum will require an understanding of the interrelated nature of the underlying conditions and an appreciation of the classroom practitioners' considerable influence upon curriculum and instruction.
Analysis of queues under correlated arrivals with applications to web server performance

The complexity of many high-volume Web sites often makes it difficult to mathematically analyze various performance measures. Since these complex behaviors can have a significant impact on performance, it is important to capture them in sufficient detail in the analysis of the corresponding queueing systems.We consider the access logs from a particular class of high-volume Web sites serving dynamic content to obtain a better understanding of the complexities of user request patterns in such environments. Our analysis demonstrates that these arrival patterns exhibit strong dependence structures which can be accurately represented by an arrival process with strong (short-range) correlations, at least for the class of Web sites motivating our study [2]. Based on these results, we develop a methodology for approximating this class of dependent arrival processes by a set of phase-type distributions. Our approach consists of formulating and solving a nonlinear optimization problem that fits a set of dependent stochastic models to approximate the interarrival time patterns from the data, which includes matching the autocorrelation function. To evaluate the effectiveness of our approach, we conduct a large number of statistical tests and experiments showing that our methodology provides an excellent match between the real user request data and the fitted approximate arrival process.Given this dependent arrival process as input, we then derive an exact matrix-analytic analysis of a general multi-server queue under two server queueing disciplines. This analysis yields results that provide significant reductions in the numerical computation required to solve the queueing models. To demonstrate the accuracy of the performance measures obtained under these methods, a large number of experiments were performed and detailed comparisons were made between the sojourn time measures from our analysis and the corresponding measures obtained from simulation of the queueing system under the actual user request data. These results show both sets of performance measures to be in excellent agreement, with relative errors consistently less than 5%, and further demonstrate the robustness of our approach. We also conduct a set of numerical experiments that exploit our matrix-analytic analysis and its computational efficiency, which are then used to establish some important results for multi-server queues under dependent arrival processes. This includes the notion of effective stability where the point at which the mean sojourn time of the queue exceeds a large constant (e.g., 1000) multiplied by the mean service time occurs well before the theoretical stability condition for the queue.Due to space limitations, we simply summarize a subset of our results in this extended abstract. We refer the interested reader to [1] for additional details, references and results.
E-Rules: An Enhanced Approach to Derive Disjunctive and useful Rules from Association Rule Mining without Candidate Item Generation

Association rule mining is one of the most important and well-researched techniques of data mining, that aims to induce associations among sets of items in transaction databases or other data repositories. Currently Apriori algorithms play a major role in identifying frequent item set and deriving rule sets out of it. However there are few shortfalls in conventional Apriori Algorithm. They are i) candidate items generation consumes lot of time in the case of large datasets ii) It supports majorly the conjunctive nature of association rules iii) The single minimum support factor to generate the effective rules. However points ii) and iii) have been addressed effectively in the earlier work [10] with reference to Apriori Algorithm. But this paper majorly worked on the above point i). In the proposed algorithm, FP growth algorithm has been taken for a reference in generating frequent item set without candidate generation. There are appreciable amount of modification and enhancements have been worked out in line with the earlier work. Besides this work also taken care the integration issues while fitting it suitably with the earlier worked out algorithm [10]. This packaged Algorithm is named as E-Rules (Effective Rules). After incorporating the modified FP Growth Algorithm, it has been observed that there is a prominent difference in time taken and performance as it does not involve candidate generations. Hence „E-Rules‟ addressing the faster generation of frequent item sets, so that to offer interesting/useful rules in an effective and optimized manner with the help of Genetic Algorithm.
National Identity in the Sports Pages: Football and the Mass Media in 1920s Buenos Aires*

The 1920s saw the emergence of a distinctive, new urban culture in the city of Buenos Aires. Although this culture did not extend to the borders of the nation, it was a national culture in the sense that it continually manufactured and reproduced images of Argentine national identity. Research conducted over the last two decades has greatly improved our understanding of this new culture. We know that it was, to a great extent, forged in the city's new, outlying barrios where manual workers lived side by side with skilled workers and members of the middle class. The relatively strong performance of the Argentine economy during these years made social mobility a more for realistic aspiration for more people than it had ever been before. Partly as a result of this economic reality, the new barrio culture revealed a less militant attitude on the part of porteño workers, a trend visible as well in the significant decline in membership and effectiveness experienced by labor unions. But the new cultural milieu reflected more than just economic prosperity; it was intimately tied to the birth of a mass culture disseminated by radio, cinema, and tabloid. In particular, the 1920s witnessed the commodification and massification of tango and football, two popular cultural practices that were now transformed into quintessential representations of Argentinidad.
An Approach to Improving Creativity and Satisfaction in Group Convergence using a Group Support System

This study examines convergence under differing divergent starting conditions in order to identify techniques which could lead to more creative outcomes and more satisfied session participants. Specifically our research asked whether or not groups in a convergence activity are more creative and satisfied based on whether they start with pre-defined ideas (i.e., examples to start with) or brainstorm on their own first. The results of the lab experiment suggest that groups who rely on pre-defined ideas when working on a convergence activity are both more creative and more satisfied than groups who brainstorm to start.
Consuming history and memory through mass media products

The representation of the past through products of the ‘culture industry’ bears the history of a long debate between detractors and optimists. This controversy becomes especially significant in a time where commercial audiovisual media affect in unprecedented ways the content and the form in which massive audiences relate to the events of the past. Even more so in a so-called postmodern moment in which public confidence in the real is overall in decline. In this context, the debate on the representation of the history and memory of the Holocaust – the paradigmatic example of limitations and imperatives to representational practice – has become a contemporary battlefield regarding the legitimacy and propriety of mass media products. By examining contemporary Holocaust representations that are at the intersection between the world of commercial mass media and the conventional nonfiction culture and documentary tradition (such as high-tech museums and Steven Spielberg’s Survivors of the Shoah Visual History Foundation), this article will reflect upon the diverse implications of the mass media–history relation.
Business and the Future: Towards a New Paradigm Based on Yoga

Business is a representative institution of our times; it represents the spirit of our age. Modern business in general has displaced a remarkable ability to change. But the change yet to come will be something unprecedented. What is the nature of this change? What is the type of vision and sirategy that will help business as a social institution, and the organizations that are part of it, to navigate this evolutionary transition successfully? Or, in other words, what is the nature of the paradigm shift needed to manage future change? These are the main questions business leaders and managers will be facing in the future. This article examines these questions in the light of Sri Aurobindo's vision.
Asthma Epidemic

When writing can change your life, when writing can enrich you by offering much money, why don't you try it? Are you still very confused of where getting the ideas? Do you still have no idea with what you are going to write? Now, you will need reading. A good writer is a good reader at once. You can define how you write depending on what books to read. This asthma epidemic can help you to solve the problem. It can be one of the right sources to develop your writing skill.
Seroepidemiology of human group C rotavirus in the UK

The gene coding for the major inner capsid protein VP6 of human group C rotavirus was cloned into baculovirus using the pBlueBac2TM vector and expressed in insect cells. When cultured in High FiveTM cells, VP6 was expressed at a high level and exported to the cell culture medium. Purified VP6 was used to immunise rabbits. Hyperimmune rabbit serum, which reacted with native human group C rotavirus in infected cells, was used to develop and optimise an EIA for the detection of antibodies to group C rotavirus using the recombinant VP6 as a source of antigen. In a local epidemiological survey of 1000 sera grouped by age, an average of 43% of samples were found to have antibodies to human group C rotavirus with the highest proportion (66%) in the 71–75 year age group. In comparison, 97% of adults and 85% of children had antibodies to recombinant VP6 from the bovine RF strain of group A rotavirus. These results suggest that infection with human group C rotavirus is a common occurrence despite the apparent rarity of reports of human group C rotavirus in clinical samples from patients with gastroenteritis. J. Med. Virol. 52:86–91, 1997. © 1997 Wiley‐Liss, Inc.
Simplifying Tennis Instruction

How many physical education programs incorporate tennis into the curriculum? How many physical educators feel proficient enough to teach tennis? Equally important, do students truly make progress when tennis is taught? Tennis instruction in secondary physical education settings is often frustrating for students and teachers alike. Many physical educators do not teach tennis because they are not tennis players themselves. Tennis, like golf, is usually left to private instruction or taught only by those with tennis experience. Schools that do teach tennis as part of their curriculum often end up repeating the same skills and drills year after year, with minimal student success. The first section of this article will describe modern groundstroke theory, keys for developing effective volleys, and step-by-step instruction on how to develop a proficient serve. It will also provide cues that instructors can use when implementing these skill lessons. The second section describes ways for teachers and their students to get the most out of skills and drills.
Measurement in psychology

Two major traditions regarding the theory and practice of measurement in psychology can be identified: the classical approach associated with the work of S. S. Stevens, and the more recently developed axiomatic approach. These two approaches are compared and related to the historical development of the logical analysis of measurement. Some practical consequences of the choice of a measurement theory paradigm are discussed, and the appropriateness of the two major approaches to guide the theory and practice of psychological measurement are evaluated.
Type C Virus Expression in Lymphoma-Paralysis-Prone Wild Mice

Abstract Wild mice trapped near Lake Casitas (LC) in southern California showed a high prevalence of infectious type C virus in the liver, spleen, and thymus within the first few weeks of life. By young adulthood about 80% of LC mice (including their genital tissues) were infected. Virus isolates from these mice cause lymphoma and lower limb paralysis under both natural and experimental conditions. Mice destined to develop paralysis showed higher levels of serum gs antigen early in life, whereas mice destined to develop lymphoma or remain free of these diseases could not be distinguished by this test. The individual variation in virus expression suggested that differences in virus type or in the immune or other host defense mechanisms greatly influenced susceptibility or resistance to indigenous type C virus-caused disease in LC wild mice.
Homelessness Comes to School

How homeless children and youths can succeed Researchers and advocates have identified successful strategies for schools enrolling homeless students. KERRI J. TOBIN is an assistant professor of education at Marywood University, Scranton, Penn. They are co-authors of Homelessness Comes to School (Corwin Press, 2011).
Design of Full Band UWB Common-Gate LNA

A two-stage, common-gate in cascade with cascode, ultra wideband low noise amplifier (LNA) topology is proposed for 3.1 to 10.5 GHz full band application. The common-gate first stage is adopted and optimized for low noise figure (NF) at high frequencies. The LNA implemented in 0.18 mum CMOS shows more than 10 dB input return loss, maximum gain of 16 dB, and NF of 3.8~4.0 dB over the full frequency band while dissipating 5.3 mA from 1.8 V supply.
Efficacy of systemic adjuvant therapies administered to dogs after excision of oral malignant melanomas: 151 cases (2001-2012).

OBJECTIVE To determine prognostic factors for and compare outcome among dogs with oral malignant melanoma following excision with or without various systemic adjuvant therapies. DESIGN Retrospective case series. ANIMALS 151 dogs with naturally occurring oral malignant melanomas treated by excision with or without adjuvant therapies from 2001 to 2012. PROCEDURES Case accrual was solicited from Veterinary Society of Surgical Oncology members via an email list service. Information collected from case records included signalment, tumor staging, tumor characteristics, type of surgical excision, histologic diagnosis, adjuvant therapy, and survival time. RESULTS The overall median survival time was 346 days. Results of multivariate analysis indicated that tumor size, patient age, and intralesional excision (vs marginal, wide, or radical excision) were considered poor prognostic indicators. All other demographic and clinical variables were not significantly associated with survival time after adjusting for the aforementioned 3 variables. A clear survival benefit was not evident with any systemic adjuvant therapy, including vaccination against melanoma or chemotherapy; however, the number of dogs in each treatment group was small. Ninety-eight dogs received no postoperative adjuvant therapy, and there was no difference in survival time between dogs that did (335 days) and did not (352 days) receive systemic adjuvant therapy. CONCLUSIONS AND CLINICAL RELEVANCE For dogs with oral malignant melanoma, increasing tumor size and age were negative prognostic factors. Complete excision of all macroscopic tumor burden improved survival time. Long-term survival was possible following surgery alone. Although systemic adjuvant therapy was not found to improve survival time, this could have been due to type II error.
Application of Data Mining Classification in Employee Performance Prediction

In emerging knowledge economies such as Kenya, organizations rely heavily on their human capital to build value. Consequently, performance management at the individual employee level is essential and the business case for implementing a system to measure and improve employee performance is strong. Data Mining can be used for knowledge discovery of interest in Human Resources Management (HRM). We used the Data Mining classification technique for the extraction of knowledge significant for predicting employee performance using previous appraisal records a public management development institute in Kenya. The Cross Industry Standard Process for Data Mining (CRISP-DM) was adopted for predictive analysis. Decision tree was the main Data Mining tool used to build the classification model, where several classification rules were generated. To validate the developed model, a prototype was constructed and the data collected from the institute’s Human Resource Department was used. Results show that employee performance was highly affected by experience, age, academic qualification, professional training, gender, marital status and previous performance appraisal scores. This paper proposes a prediction model for employee performance forecasting that
Corolla based circuit partitioning and resynthesis

Application of corolla-based partitioning to improve synthesis of large multi-level logic circuits is introduced. First, stem regions, petals, and corollas are defined. Next, the partitioning algorithm is outlined and the resynthesis process is described. Results of partitioning and logic resynthesis on a variety of large circuit benchmarks are summarized. It is found that logic resynthesis based on corolla partitioning consistently reduces reconvergent fanout branches, transistor pairs and layout areas, while improving circuit delay and testability. <<ETX>>
Thinking of marketing in meridian terms

The present article sustains the idea of a Mediterranean approach to marketing by highlighting one of the major differentiating traits of ‘Meridian thinking’, as defined by Cassano: a sense of proportion that makes it possible to trace the main directions of a moderate marketing approach capable of avoiding the excesses characterizing so many marketing proposals on offer today.
Bluetooth devices for the optimization ofpatients' workflow in a radiation oncology department

The costs of healthcare administrations are continuously increasing and techniques able of reducing costs and optimizing systems are necessary. The use of information and communications technology (ICT), such as Bluetooth (BT) Activity Tracker (ACT) devices, can expand and improve the capabilities of the management structures. We propose to extend the application of this widespread technology even in the medical environment The aim of our work is to apply BT-ACTs for workflow management and patients' performance monitoring in a Radiation Oncology Department. Indeed, in such medical department working on outpatients based regimen, workflow and clinical control may be complex. Our preliminary experience in using ACT in a Radiation Oncology Department of an Academic Institution is described. The integration of ACT with a novel electronic medical record archiving and retrieving system is implemented. We show that using BT-ACT is possible to successfully monitor patient workflow and biometric data during radiation treatment.
Corrected and Republished from: The COP9 Signalosome Interacts with and Regulates Interferon Regulatory Factor 5 Protein Stability

ABSTRACT The transcription factor interferon regulatory factor 5 (IRF5) exerts crucial functions in the regulation of host immunity against extracellular pathogens, DNA damage-induced apoptosis, death receptor signaling, and macrophage polarization. Tight regulation of IRF5 is thus warranted for an efficient response to extracellular stressors and for limiting autoimmune and inflammatory responses. Here we report that the COP9 signalosome (CSN), a general modulator of diverse cellular and developmental processes, associates constitutively with IRF5 and promotes its protein stability. The constitutive CSN/IRF5 interaction was identified using proteomics and confirmed by endogenous immunoprecipitations. The CSN/IRF5 interaction occurred on the carboxyl and amino termini of IRF5; a single internal deletion (Δ455-466) was found to significantly reduce IRF5 protein stability. CSN3 was identified as a direct interacting partner of IRF5, and knockdown of this subunit with small interfering RNAs (siRNAs) resulted in enhanced degradation. Degradation was further augmented by knockdown of CSN1 and CSN3 together. The ubiquitin E1 inhibitor UBEI-41 or the proteasome inhibitor MG132 prevented IRF5 degradation, supporting that its stability is regulated by the ubiquitin-proteasome system. Importantly, activation of IRF5 by the death receptor ligand tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) resulted in enhanced degradation via loss of the CSN/IRF5 interaction. This study defines the CSN as a new interacting partner of IRF5 that controls its stability.