Miracle-dz/UniFAR-FTUs huggingface dataset:
Enhancing Ontology Concept Design by Knowledge Discovery

In this paper, we propose a knowledge discovery-based approach to ontology concept design. In our approach, concept design is a stepwise activity which exploits ontology matching techniques in order to retrieve useful external concepts semantically related to the design at hand. This way, the resulting ontology knowledge space is open towards external knowledge sources, by complementing the ontology expert knowledge with domain knowledge stored in other external sources, such as other domain ontologies, Web directories, and, in general, the semantic Web.
RESPUESTA INFLAMATORIA Y ANTIINFLAMATORIA TRAS EL ESFUERZO AGUDO EN NATACIÓN // INFLAMMATORY AND ANTINFLAMMATOY RESPONSE AFTER SWIMMING ACUTE EFFORT

RESUMEN El objetivo del estudio fue analizar la respuesta inflamatoria y antiinflamatoria a un esfuerzo agudo e intenso de natacion, durante la fase preparatoria para los campeonatos nacionales absolutos brasilenos. Participaron 20 nadadores. Se determinaron las concentraciones plasmaticas de IL-6, TNF-α, sTNFR1, IP-10 y MCP-1, antes y 40 minutos despues de 2 series de 4 repeticiones de 50 metros nadados a la maxima intensidad con 3 minutos de recuperacion entre cada repeticion y una recuperacion activa nadando 1500m a intensidad suave despues de cada una de las dos series. En respuesta al ejercicio agudo unicamente la concentracion sTNFR1 se redujo, no presentando cambios en IP 10, IL-6 ni TNF-α. Por tanto el ejercicio agudo en natacion en personas bien entrenadas no parece producir una respuesta inflamatoria. PALABRAS CLAVE: natacion, citoquinas, quimiocinas. ABSTRACT The mean of the study was to analyze the inflammatory and anti-inflammatory response to an intense and intense swimming effort during the preparatory phase for the Brazilian National Adult Championship. Twenty swimmers participated. Plasma concentrations of IL-6, TNF-α, sTNFR1, IP-10 and MCP-1 were determined before and 40 minutes after 2 sets of 4 repetitions of 50 meters swam at maximum intensity with 3 minutes of recovery between each repetition and an active recovery swimming 1500m at low intensity after each of the two series. In response to acute exercise only the sTNFR1 concentration was reduced, with no changes in IP-10, IL-6 or TNF-α. Thus, acute exercise in swimming in well-trained people does not seem to produce an inflammatory response. KEY WORDS: swimming, citokynes, chemokines.
Fault detectability condition of networked control system with variable network-induced delay

This paper focuses on fault detectability condition for Networked Control Systems (NCSs) with induced delay. In this paper, Jordan form of matrices is used in order to construct an appropriate model of the system. Next, linear model of NCS in the presence of network induced delay is achieved. Finally, necessary and sufficient conditions of fault detectability of NCS are provided.
Insufficient penetration of systemic vancomycin into the PermCath lumen.

BACKGROUND Catheter infection is a major cause of morbidity and catheter loss in chronic haemodialysis patients. There has been a large discrepancy in the catheter salvage rate, after an episode of documented bacteraemia, whether the patients receive systemic antibiotic alone or systemic antibiotics concomitant with 'antibiotic-lock technique' (20-30% vs 100%, respectively). To test the hypothesis that vancomycin may not adequately penetrate into the lumen of the catheter, despite therapeutic plasma levels, a series of in-vivo, ex-vivo, and in-vitro experiments were performed. METHODS We compared serum and intralumenal (0.3-0.5 ml aspirate from venous port of the catheter) vancomycin concentrations in 24 chronic haemodialysis patients, with documented bacteraemia, who had received prior systemic vancomycin therapy with 14 similar patients who had additionally received 'vancomycin-lock technique' (100 microg/ml of vancomycin in heparin solution) after each haemodialysis session. RESULTS Despite serum vancomycin concentration of approximately 17 microg/ml in each group, the vancomycin concentration in the venous hub of the catheter was only 0.2+/-0.6 microg/ml in the former group, in sharp contrast to 125. 6+/-13 microg/ml in the latter group. In the ex-vivo experiment, four uninfected PermCaths which had been removed were immediately fixed and studied with scanning electron microscopy. No cellular or fibrin barrier could be found at the terminal pore of the catheter interfering with the diffusion of vancomycin from plasma into the catheter lumen. In the in-vitro experiments, three PermCaths filled with standard heparin solution were incubated for 48 h in 100 ml of plasma containing 20 microg/ml of vancomycin. Vancomycin concentration was measured in 0.3-0.5 ml solution aspirated from each port of the catheters. Vancomycin concentration was 0.2+/-0.1 microg/ml in the aspirated samples. Finally, two PermCaths filled with the standard heparin solution were incubated for 48 h in 100 ml of plasma containing 20 microg/ml of vancomycin, after which the catheters were sectioned at 4-cm intervals. Only the distal 4 cm of the catheters had vancomycin concentrations of 2 and 5 microg/ml, the remaining segments had levels </=0.5 microg/ml. CONCLUSION. : Our results indicate that diffusion of vancomycin from plasma into the haemodialysis catheter is negligible. Thus, haemodialysis patients with central venous catheter who have to be treated for bacteraemia with systemic antibiotic therapy must always receive 'antibiotic-lock technique' of the catheter after each haemodialysis session.
A Clean-Slate Design for the Next-Generation Secure Internet

This is the report on a workshop held at CMU on July 12–14, 2005. The workshop is part of the planning process initiated by NSF to explore potential architectures for a next generation secure network designed to meet the needs of the 21st century. In considering future architectures, we ignore issues of backward compatibility with the current Internet but seek to benefit from the experience gained by analyzing both the strengths and weaknesses of the current design. Specifically, this workshop looks at the fundamental interplay between security and underlying network architecture and seeks to chart a preliminary course for future work in this crucial research area. This workshop focused on initiating a productive dialog between experts from the network security and network architecture communities. The agenda was arranged to stimulate initial consideration of the security goals for a new Internet, the design space of possible solutions, how research in security and network architecture could be integrated so that security is included as a first-tier objective in future architectures, and to explore methods for identifying and considering the social consequences of these architecture and security design choices.
A THEORY OF STATE FORMATION AND THE ORIGINS OF INEQUALITY (

(*) Previous versions of this paper were presented at the University of Virginia, the New York meeting of the “September Group” Princeton University, Duke University, Yale University, Stanford University, the University of Chicago and Harvard University. I thank the comments of all their participants, in particular to those of Sam Bowles, Dan Gingerich, Stathis Kalyvas, Carol Mershon, Thomas Romer and Milan Svolik. I am especially grateful to the comments of Alicia Adsera and to Teppei Yamamoto for his research assistance.
Switching Control for Adaptive Disturbance Attenuation

The problem of adaptive disturbance attenuation is addressed in this paper using a switching control approach. A finite family of stabilizing controllers is pre-designed, with the assumption that, for any possible operating condition, at least one controller is able to achieve a prescribed level of attenuation. Then, at each time instant, a supervisory unit selects the controller associated with the best potential performance on the basis of suitably defined test functionals. In the paper, we prove some important properties which are satisfied by the test functionals, and analyze the stability of the overall switched system. Simulation results are provided to show the validity of the proposed method as a solution to the problem.
Joint blind equalization with a shell partition-based CMA for QAM signal constellations

For quadrature-amplitude modulation (QAM) systems, the joint blind equalization (JBE) algorithm, concatenation of two different equalization modes, has been widely used. After the eye is opened by the blind equalization mode, the decision-directed (DD) mode follows to improve the equalization performance with fast convergence. This paper proposes a shell partition-based constant modulus algorithm (CMA) (SPCMA) which acts as the DD mode in the JBE. Computer simulation results for 16-QAM show the effectiveness of the proposed JBE.
Routing games with an unknown set of active players

In many settings there exists a set of potential participants, but the set of participants who are actually active in the system, and in particular their number, is unknown. This topic has been first analyzed by Ashlagi, Monderer, and Tennenholtz [AMT] in the context of simple routing games, where the network consists of a set of parallel links, and the agents can not split their jobs among different paths. AMT used the model of pre-Bayesian games, and the concept of safety-level equilibrium for the analysis of these games. In this paper we extend the work by AMT. We deal with splitable routing games, where each player can split his job among paths in a given network. In this context we generalize the analysis to all two-node networks, in which paths may intersect in unrestricted manner. We characterize the relationships between the number of potential participants and the number of active participants under which ignorance is beneficial to each of the active participants.
Novel frequency quadrupler design covering the entire V-Band in 0.13-μm SiGe process

This paper presents a novel quadrupler design that adopts the proposed polyphase filter based doubler as the first stage, which generates a differential output signal for the second doubler stage. The polyphase filter based solution features a compact size, a wide bandwidth and a well balanced output. The quadrupler is implemented in a 0.13 μm SiGe:C HBT process, and demonstrates a wide bandwidth of 50 - 75 GHz with only 1.8 dB gain variation, a conversion gain of 12 dB, and a output power of about -1 dBm.
Epidemiology of Dengue Virus in Iquitos, Peru 1999 to 2005: Interepidemic and Epidemic Patterns of Transmission

Background Comprehensive, longitudinal field studies that monitor both disease and vector populations for dengue viruses are urgently needed as a pre-requisite for developing locally adaptable prevention programs or to appropriately test and license new vaccines. Methodology and Principal Findings We report the results from such a study spanning 5 years in the Amazonian city of Iquitos, Peru where DENV infection was monitored serologically among ∼2,400 members of a neighborhood-based cohort and through school-based absenteeism surveillance for active febrile illness among a subset of this cohort. At baseline, 80% of the study population had DENV antibodies, seroprevalence increased with age, and significant geographic variation was observed, with neighborhood-specific age-adjusted rates ranging from 67.1 to 89.9%. During the first 15 months, when DENV-1 and DENV-2 were co-circulating, population-based incidence rates ranged from 2–3 infections/100 person-years (p-years). The introduction of DENV-3 during the last half of 2001 was characterized by 3 distinct periods: amplification over at least 5–6 months, replacement of previously circulating serotypes, and epidemic transmission when incidence peaked at 89 infections/100 p-years. Conclusions/Significance Neighborhood-specific baseline seroprevalence rates were not predictive of geographic incidence patterns prior to the DENV-3 introduction, but were closely mirrored during the invasion of this serotype. Transmission varied geographically, with peak incidence occurring at different times among the 8 geographic zones in ∼16 km2 of the city. The lag from novel serotype introduction to epidemic transmission and knowledge of spatially explicit areas of elevated risk should be considered for more effective application of limited resources for dengue prevention.
How interacting constraints shape emergent decision-making of national-level football referees

ABSTRACT Here, using a grounded theory methodology, we explored the experiential knowledge of nine national-level Association Football referees (aged 23–35 yrs; 3.8 yrs mean minimum national-level experience) with the aim of better understanding why referees make decisions during performance. Results indicated that referee decision-making actions were not predominantly aimed at traditional notions of decision-making accuracy (e.g. correctly identifying rule transgressions), but were instead focussed on meeting two overarching task goals: maintaining control and preserving the integrity of the competitive game. These objectives were, in part, informed by co-invested task outcomes, which referees perceived that players, spectators, coaches and fellow referees had about ‘how the game should be played’. Analysis revealed four decision-making priorities (‘four pillars’) used to meet these expectations; these were conceptual notions of: safety, fairness, accuracy and entertainment. We discuss how these results provide a case that: (i) referees co-construct the game with players and (ii) referee decision-making is an emergent process of the performer–environment relationship nested within task goals. Finally, we recommend that future research investigate decision-making accuracy within the context of a competitive match and that distinctions be made between types of bias and the complex strategies referees use to manage the game.
Galaxy transmutations: The double ringed galaxy ESO 474-G26

Surface photometry and a 21 cm H  line spectrum of the giant double-ringed galaxy ESO 474-G26 are presented. The morphology of this system is unique among the 30 000 galaxies with B ≤15. 5. Two almost orthogonal optical rings with diameters of 60 and 40 kpc surround the central body (assuming H0 = 70 km s −1 Mpc −1 ). The outer one is an equatorial ring, while the inner ring lies in a nearly polar plane. The rings have blue optical colors typical of late-type spirals. Both appear to be rotating around the central galaxy, so that this system can be considered as a kinematically confirmed polar ring galaxy. Its observational characteristics are typical of galaxy merger remnants. Although the central object has a surface brightness distribution typical of elliptical galaxies, it has a higher surface brightness for its effective radius than ordinary ellipticals. Possible origins of this galaxy are discussed and numerical simulations are presented that illustrate the formation of the two rings in the merging process of two spiral galaxies, in which the observed appearance of ESO 474-G26 appears to be a transient stage.
Involvement of aquaporin-4 in astroglial cell migration and glial scar formation

Aquaporin-4, the major water-selective channel in astroglia throughout the central nervous system, facilitates water movement into and out of the brain. Here, we identify a novel role for aquaporin-4 in astroglial cell migration, as occurs during glial scar formation. Astroglia cultured from the neocortex of aquaporin-4-null mice had similar morphology, proliferation and adhesion, but markedly impaired migration determined by Transwell migration efficiency (18±2 vs 58±4% of cells migrated towards 10% serum in 8 hours; P<0.001) and wound healing rate (4.6 vs 7.0 μm/hour speed of wound edge; P<0.001) compared with wild-type mice. Transwell migration was similarly impaired (25±4% migrated cells) in wild-type astroglia after ∼90% reduction in aquaporin-4 protein expression by RNA inhibition. Aquaporin-4 was polarized to the leading edge of the plasma membrane in migrating wild-type astroglia, where rapid shape changes were seen by video microscopy. Astroglial cell migration was enhanced by a small extracellular osmotic gradient, suggesting that aquaporin-4 facilitates water influx across the leading edge of a migrating cell. In an in vivo model of reactive gliosis and astroglial cell migration produced by cortical stab injury, glial scar formation was remarkably impaired in aquaporin-4-null mice, with reduced migration of reactive astroglia towards the site of injury. Our findings provide evidence for the involvement of aquaporin-4 in astroglial cell migration, which occurs during glial scar formation in brain injury, stroke, tumor and focal abscess.
LuGre-Model-Based Friction Compensation

A tracking problem for a mechanical system is considered. We start with a feedback controller that is designed without attention to disturbances, which are assumed to be adequately described by a dynamic LuGre friction model. We are interested in deriving a superimposed observer-based compensator to annihilate or reduce the influence of such a disturbance. We exploit a recently suggested approach for observer design for LuGre-friction-model-based compensation. In order to apply this technique, it is necessary to know the Lyapunov function for the unperturbed system, as well as the parameters of the dynamic friction model, and to verify that a certain structural property satisfied. The case when the system is passive with respect to the matching disturbance related to the given Lyapunov function is illustrated in this brief with a DC-motor example. The main contribution is some new insights into the numerical real-time implementation of a compensator for disturbances describable by one of various LuGre-type models. The other contribution, which is built upon the main one, is experimental verification of the suggested model-based observer design procedure.
Developing indicators for European birds

The global pledge to deliver ‘a significant reduction in the current rate of biodiversity loss by 2010’ is echoed in a number of regional and national level targets. There is broad consensus, however, that in the absence of conservation action, biodiversity will continue to be lost at a rate unprecedented in the recent era. Remarkably, we lack a basic system to measure progress towards these targets and, in particular, we lack standard measures of biodiversity and procedures to construct and assess summary statistics. Here, we develop a simple classification of biodiversity indicators to assist their development and clarify purpose. We use European birds, as example taxa, to show how robust indicators can be constructed and how they can be interpreted. We have developed statistical methods to calculate supranational, multi-species indices using population data from national annual breeding bird surveys in Europe. Skilled volunteers using standardized field methods undertake data collection where methods and survey designs differ slightly across countries. Survey plots tend to be widely distributed at a national level, covering many bird species and habitats with reasonable representation. National species' indices are calculated using log-linear regression, which allows for plot turnover. Supranational species' indices are constructed by combining the national species' indices weighted by national population sizes of each species. Supranational, multi-species indicators are calculated by averaging the resulting indices. We show that common farmland birds in Europe have declined steeply over the last two decades, whereas woodland birds have not. Evidence elsewhere shows that the main driver of farmland bird declines is increased agricultural intensification. We argue that the farmland bird indicator is a useful surrogate for trends in other elements of biodiversity in this habitat.
This information is current as TRAIL-Enhanced Apoptosis in Cancer Cells Inhibitor NPI-0052 Contributes to its Expression by the Novel Proteasome Repressor Activity of DR5 Transcription and Inhibition of Yin Yang 1-Dependent

TRAIL promotes apoptotic tumor cell death; however, TRAIL-resistant tumors need to be sensitized to reverse resistance. Proteasome inhibitors potentiate TRAIL apoptosis in vitro and in vivo and correlate with up-regulation of death receptor 5 (DR5) via an unknown mechanism. We hypothesized that the proteasome inhibitor NPI-0052 inhibits the transcription repressor Yin Yang 1 (YY1) which regulates TRAIL resistance and negatively regulates DR5 transcription. Treatment of PC-3 and Ramos cells with NPI-0052 ( < 2.5 nM) and TRAIL sensitizes the tumor cells to TRAIL-induced apoptosis. By comparison to bortezomib, a 400-fold less concentration of NPI-0052 was used. NPI-0052 up-regulated DR5 reporter activity and both surface and total DR5 protein expression. NPI-0052-induced inhibition of NF- (cid:1) B activity was involved in TRAIL sensitization as corroborated by the use of the NF- (cid:1) B inhibitor dehydroxymethylepoxyquinomicin. NPI-0052 inhibited YY1 promoter activity as well as both YY1 mRNA and protein expression. The direct role of NPI-0052-induced inhibition of YY1 and up-regulation of DR5 in the regulation of TRAIL sensitivity was demonstrated by the use of YY1 small interfering RNA. The NPI-0052-induced sensitization to TRAIL involved activation of the intrinsic apoptotic pathway and dysregulation of genes that regulate apoptosis. The NPI-0052 concentrations used for TRAIL sensitization were not toxic to human hematopoetic stem cells. The present ﬁndings demonstrate, for the ﬁrst time, the potential mechanism by which a proteasome inhibitor, like NPI-0052, inhibits the transcription repressor YY1 involved in TRAIL resistance and DR5 regulation. The ﬁndings also suggest the therapeutic application of subtoxic NPI-0052 concentrations in combination with TRAIL/agonist DR4/DR5 mAbs in the treatment of TRAIL-resistant tumors. The Journal of Immunology, 2008, 180: 6199–6210. antiapoptotic
System info of multi-domain cognition in cognitive radio networks

The environment cognition of cognitive radio networks (CRN) is extending from wireless domain (WD) to network domain (ND), user domain (UD) and policy domain (PD). In this paper, we propose three-layer system info of multi-domain cognition (MDC) with the characteristic of policy restriction and the capability of learning and reasoning. Especially, multi-domain local cognition (MDLC) layer performs the acquirement of mass multi-domain cognition information (CI). Integrative consideration of effective expression, efficient transfer and distributive processing, multi-domain cooperative cognition (MDCC) layer implements rational flow and fusion of CI and multi-domain initiative cognition (MDIC) layer effectively utilizes CI by prediction and reasoning. After interpreting the connotation of MDC, we also present cognition framework in space and the simple mathematic model of MDC. In addition, we present the research challenges ahead as well.
Forensic Analysis of Geodata in Android Smartphones

Smartphones provide a lot of interesting data for a forensic investigator. As many apps make use of location information to provide or enhance their services, the log files of smartphones can contain valuable geodata. Based on geodata it is possible to reconstruct the whereabouts of the phone and its user at certain points in time. The functionality to analyse geodata based on GPS coordinates is standard for many mobile forensics tools. Unfortunately, many smartphone apps log their geodata in human readable format only, which makes it harder for investigators to get and analyse this important information. This paper proposes a simple but comprehensive approach to the analysis of all geodata on a smartphone. The approach uses simple app-specific descriptions of the geodata information stored in smartphones and thus enables an automatic extraction and presentation of all relevant geodata. The approach is currently being implemented for Android smartphones.