Miracle-dz/UniFAR-FTUs huggingface dataset:
The Progressive Ankylosis Protein Regulates Cementum Apposition and Extracellular Matrix Composition

Background/Aims: Tooth root cementum is sensitive to modulation of inorganic pyrophosphate (PPi), an inhibitor of hydroxyapatite precipitation. Factors increasing PPi include progressive ankylosis protein (ANK) and ectonucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) while tissue nonspecific alkaline phosphatase hydrolyzes PPi. Studies here aimed to define the role of ANK in root and cementum by analyzing tooth development in Ank knock-out (KO) mice versus wild type. Materials and Methods: Periodontal development in KO versus control mice was analyzed by histology, histomorphometry, immunohistochemistry, in situ hybridization, electron microscopy, and nanoindentation. Cementoblast cultures were used in vitro to provide mechanistic underpinnings for PPi modulation of cell function. Results: Over the course of root development, Ank KO cervical cementum became 8- to 12-fold thicker than control cervical cementum. Periodontal ligament width was maintained and other dentoalveolar tissues, including apical cementum, were unaltered. Cervical cementum uncharacteristically included numerous cells, from rapid cementogenesis. Ank KO increased osteopontin and dentin matrix protein 1 gene and protein expression, and markedly increased NPP1 protein expression in cementoblasts but not in other cell types. Conditional ablation of Ank in joints and periodontia confirmed a local role for ANK in cementogenesis. In vitro studies employing cementoblasts indicated that Ank and Enpp1 mRNA levels increased in step with mineral nodule formation, supporting a role for these factors in regulation of cementum matrix mineralization. Conclusion: ANK, by modulating local PPi, controls cervical cementum apposition and extracellular matrix. Loss of ANK created a local environment conducive to rapid cementogenesis; therefore, approaches modulating PPi in periodontal tissues have potential to promote cementum regeneration.
Mining inter-transaction association rules from multiple time-series data

Association rule mining is one of the most widely used methods for discovering interesting relations between variables. Time series as a common sequence data have some unique character, such as pervasively connected, endless and time-related. Therefore research on multivariate time series data mining is a hot spot in data mining. This paper first compresses the continuous time series. Then in order to make the mining rules reflect the characteristics of multivariate time series data, our paper designs a new algorithm called IAMTL, which can mine the rules from the fix time span. For the reason that time series data have the characteristic of continuity, so an increment version of IATML is provided. At last, we use prerequisite and the consequent windows to verify the correctness of the rules.
L-Borneol induces transient opening of the blood–brain barrier and enhances the therapeutic effect of cisplatin

The blood–brain barrier (BBB) protects the central nervous system from external insults by limiting substance diffusion through the endothelial interface. The presence of the BBB makes drug delivery in neurological disorders very challenging. Cisplatin has been shown to be cytotoxic to glioma cells, but substantial limitations exist in its clinical applications due to difficulties in penetration across the BBB. Here, we show that L-borneol, a messenger drug widely used in traditional Chinese medicine, can induce transient disruption of the BBB after 20 min of oral administration. The permeability of the BBB began to recover within 1 h of the administration of L-borneol. Different dosages of L-borneol (100, 150, 300, 600, and 900 mg/kg) could induce significant Evans blue leakage (P<0.05). Oral administration of L-borneol elevated cisplatin concentrations in peritumoral tissue (1.24±0.12 &mgr;g/g) and tumor loci (1.41±0.13 &mgr;g/g), compared with those in the paraffin control (0.88±0.10 and 0.92±0.15 &mgr;g/g, respectively) (P<0.05). Furthermore, we found that the median survival period of tumor-bearing mice was significantly higher in the cisplatin plus L-borneol group (24.0±4.9 days) than in the cisplatin plus vehicle group (19.3±3.9 days) (P<0.05). The neurological deficits were more severe in the vehicle and cisplatin plus vehicle groups at 14 and 21 days after implantation of intracranial glioma cells than in the cisplatin plus L-borneol group. In conclusion, our results indicate that the transient opening of the BBB induced by L-borneol could enhance cisplatin accumulation within the glioma tissue and improve the survival of tumor-bearing mice.
Protective Effect of Cleome Viscosa Extract on Diet Induced Atherosclerosis in Diabetic Rats

The atherosclerotic effect of Methanolic extract of Cleome viscosa was studied in Streptozotocin induced Diabetic Rats fed with Atherogenic Diet [1.5 ml olive oil containing 8 mg of vitamin D-2 and 40 mg cholesterol] for 5 consecutive days. Oral administration of extract to diabetic rats [250 mg/kg and 500 mg/kg for 30 days] produced significant (p<0.01) fall in fasting blood glucose levels in a dose dependent manner, when compared to standard drug that is Glibinclamide (5 mg/kg). Treatment with extract 250 mg/kg and 500 mg/kg showed significant (P<0.01) improvement serum lipids levels that is total cholesterol, triglycerides(TG), low density lipoprotein(LDL) and very low density lipoprotein(VLDL), when compared to diabetic control. Histopathological studies of aorta also confirmed biochemical findings. Thus, our study shows that Methanolic extract of Cleome viscosa (250 mg/kg and 500 mg/kg) significantly improves the homeostasis of glucose and fat and possess anti atherosclerotic activity.
Naming scheme using NLP machine learning method for network weather monitoring system based on ICN

The market for IoT devices has been expanding rapidly for several years, and many fields are anticipating further demand in the future. However, together with this expansion, increased communication failures are expected, and solutions to prevent them are needed. Here, we aim to solve communication problems using a new network, called the CCN x (Contents Centric Networking), which is one of the leading ICN (Information Centric Networking) solutions. Our system was constructed by assuming the case of a weather monitoring IoT application in which large data communications were very likely to occur. In this paper, we propose a technique for distributing meteorological data gathered with a weather observation device and 4K camera by ICN, and caching content with a new Naming scheme using machine learning.
Distribution of alkaloids in woody plants

Isabel.Desgagne-Penix@uqtr.ca Abstract Alkaloids are nitrogen-containing compounds found in plants. Most are highly valued for their role in wide array of ailments such as anti-malarial, anti-cancerous, analgesics, and many more. In lights of tremendous interest in recent years on the chemistry and pharmacological properties of alkaloids, comprehensive data have been collected. Forest industries have recently started to develop sustainable ways to increase the value of its residues including the extraction and commercialization of high-valued plant natural compounds such as alkaloids. This review presents the distribution of alkaloids among woody plants (trees and shrubs).
THE ‘ MINUTE RHYTHM ’ INCIDENCE IN THE OVINE ABOMASAL ANTRUM AND SMALL

To characterise further the ‘minute rhythm’, six healthy rams were equipped with serosal electrodes sewn onto the abomasal antrum and the small bowel. The experiments were performed before and after feeding. Food was offered during phase 2a or 2b of the migrating motility complex. The ‘minute rhythm’ incidence and coordination were assessed during four 5-minute observation periods. In the duodenal bulb and duodenum, the pattern was observed more frequently than in other segments examined. During phase 2b, the ‘minute rhythm’ incidence was often more frequent than during phase 2a of the migrating motility complex. Feeding increased significantly the ‘minute rhythm’ incidence, but these alterations were more evident during first two observation periods. In the jejunum, duration of one ‘minute rhythm’ episode was longer than in more proximal segments. In the more distal jejunal recording site the ‘minute rhythm’ was often absent. The pattern was well coordinated mostly in the antroduodenum and its propagation velocity was the highest also in the upper small bowel. It is concluded that the ‘minute rhythm’ incidence, form, and coordination depended upon the feeding conditions, intensity of intestinal motility and the gastrointestinal segment.
Quantifying structural modifications of gills of two fish species Astyanax altiparanae (Lambari) and Prochilodus lineatus (Curimbatá) after exposure to biodegradable detergents in urban lake water

ABSTRACT Anthropic actions in rivers and urban lakes are a cause for concern to our ecosystem. The effects on fauna and flora of substances discharged into waterways have become a focus for investigations globally. Biodegradable detergents are widely used in residences and small industries, but little is known regarding the consequences on fish fauna. The objective of the present study was to identify modifications in gill structure in two fish species, Astyanax altiparanae and Prochilodus lineatus, after treatment with water obtained from an urban lake and an exposure to 1 ppm diluted biodegradable detergents (linear alkylbenzene sulfonate). Data demonstrated exposure to urban lake produced various alterations in gill functions such as lamellar fusions, aneurysms, mucous, and chlorine cell proliferation, which may be attributed to the presence of detergents in the water but may also be a consequence of synergetic actions of detergents with other pollutants. Results showed that the levels of NO−2, Na, F–, Cl–, and Fe were significantly higher in urban lake water but in the presence of detergents Ni was also detected. Evidence indicates that biodegradable detergents produce damage to gill functions, which subsequently alters the fish physiology and reduces the ability to cope with stress and survival.
Circulating Tumor DNA Analysis in Patients With Cancer: American Society of Clinical Oncology and College of American Pathologists Joint Review.

PURPOSE. — Clinical use of analytical tests to assess genomic variants in circulating tumor DNA (ctDNA) is increasing. This joint review from the American Society of Clinical Oncology and the College of American Pathologists summarizes current information about clinical ctDNA assays and provides a framework for future research. METHODS. — An Expert Panel conducted a literature review on the use of ctDNA assays for solid tumors, including preanalytical variables, analytical validity, interpretation and reporting, and clinical validity and utility. RESULTS. — The literature search identified 1338 references. Of those, 390, plus 31 references supplied by the Expert Panel, were selected for full-text review. There were 77 articles selected for inclusion. CONCLUSIONS. — The evidence indicates that testing for ctDNA is optimally performed on plasma collected in cell stabilization or EDTA tubes, with EDTA tubes processed within 6 hours of collection. Some ctDNA assays have demonstrated clinical validity and utility with certain types of advanced cancer; however, there is insufficient evidence of clinical validity and utility for the majority of ctDNA assays in advanced cancer. Evidence shows discordance between the results of ctDNA assays and genotyping tumor specimens, and supports tumor tissue genotyping to confirm undetected results from ctDNA tests. There is no evidence of clinical utility and little evidence of clinical validity of ctDNA assays in early-stage cancer, treatment monitoring, or residual disease detection. There is no evidence of clinical validity or clinical utility to suggest that ctDNA assays are useful for cancer screening, outside of a clinical trial. Given the rapid pace of research, reevaluation of the literature will shortly be required, along with the development of tools and guidance for clinical practice.
Bacterial foraging optimization algorithm with temporal features to solve data sparsity in recommendation system

A recommender system provides users with personalized suggestions for items based on the user's behaviour history. This system often uses the collaborative filtering for analysing the rating scores of users for items in the scoring matrix. The scoring matrix of a recommendation system contains a high percentage of data sparsity which lowers the quality of the prediction based on the collaborative filtering. Recently, the temporal with matrix factorization is one of the successful collaborative-based approaches which address data sparsity. However, the user's rating scores have drifted over time and the predicted rating scores are over-fitted which are the significant challenges in the temporal based factorization approaches. Therefore, the ShortTemporalMF approach has proposed to address these challenges. The ShortTemporalMF uses the bacterial foraging optimization algorithm (BFOA) and the k-means algorithm to minimize the over-fitting by exploiting several latent features. BFOA learns the drift in the latent space according to tracking the rich nutrients. The ShortTemporalMF is tested on the Netflix Prize dataset. The experimental results show that the prediction accuracy of ShortTemporalMF approach is the highest compared to the prediction accuracy of whole benchmark approaches of factorization and temporal.
PPARγ activation by troglitazone enhances human lung cancer cells to TRAIL-induced apoptosis via autophagy flux

Members of the tumor necrosis factor (TNF) transmembrane cytokine superfamily, such as TNFα and Fas ligand (FasL), play crucial roles in inflammation and immunity. TRAIL is a member of this superfamily with the ability to selectively trigger cancer cell death but does not motive cytotoxicity to most normal cells. Troglitazone are used in the cure of type II diabetes to reduce blood glucose levels and improve the sensitivity of an amount of tissues to insulin. In this study, we revealed that troglitazone could trigger TRAIL-mediated apoptotic cell death in human lung adenocarcinoma cells. Pretreatment of troglitazone induced activation of PPARγ in a dose-dependent manner. In addition conversion of LC3-I to LC3-II and PPARγ was suppressed in the presence of GW9662, a well-characterized PPARγ antagonist. Treatment with troglitazone resulted in a slight increase in conversion rate of LC3-I to LC3-II and significantly decreased p62 expression levels in a dose-dependent manner. This indicates that troglitazone induced autophagy flux activation in human lung cancer cells. Inhibition of autophagy flux applying a specific inhibitor and genetically modified ATG5 siRNA enclosed troglitazone-mediated enhancing effect of TRAIL. These data demonstrated that activation of PPARγ mediated by troglitazone enhances human lung cancer cells to TRAIL-induced apoptosis via autophagy flux and also suggest that troglitazone may be a combination therapeutic target with TRAIL protein in TRAIL-resistant cancer cells.
Ticagrelor in Acute Stroke or Transient Ischemic Attack in Asian Patients: From the SOCRATES Trial (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes)

Background and Purpose— In the SOCRATES trial (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes), ticagrelor was not superior to aspirin. Because of differences in patient demographics and stroke disease pattern in Asia, outcomes of ticagrelor versus aspirin were assessed among Asian patients in a prespecified exploratory analysis. Methods— Baseline demographics, treatment effects, and safety of ticagrelor and aspirin were assessed among Asian patients. Differences in outcomes between groups were assessed using Cox proportional hazard model. Results— A total of 3858 (29.2%) SOCRATES participants were recruited in Asia. Among the Asian patients, the primary end point event occurred in 186 (9.6%) of the 1933 patients treated with ticagrelor, versus 224 (11.6%) of the 1925 patients treated with aspirin (hazard ratio, 0.81; 95% confidence interval, 0.67–0.99). The exploratory P value for treatment-by-region interaction was 0.27. The primary end point event rate in the Asian subgroup was numerically higher than that in the non-Asian group (10.6% versus 5.7%; nominal P<0.01). Among the Asian patients, the rate of PLATO (Platelet Inhibition and Patient Outcomes)–defined major bleeding was similar in the ticagrelor group and the aspirin group (0.6% versus 0.8%; hazard ratio, 0.76; 95% confidence interval, 0.36–1.61). Conclusions— The event rates were numerically higher in the Asian patients. Among the Asian patients with acute stroke or transient ischemic attacks, there was a trend toward a lower hazard ratio in reducing risk of the primary end point of stroke, myocardial infarction, or death in the ticagrelor group. Clinical Trial Registration— URL: http://www.clinicaltrials. gov. Unique identifier: NCT01994720.
Normalization of EMG Signals: To Normalize or Not to Normalize and What to Normalize to?

© 2012 Halaki and Ginn, licensee InTech. This is an open access chapter distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Normalization of EMG Signals: To Normalize or Not to Normalize and What to Normalize to?
Modulating role of estradiol on arginase II expression in hyperlipidemic rabbits as an atheroprotective mechanism

We evaluated the effects of a 0.5% cholesterol-enriched diet (HCD) on nitric-oxide synthase (NOS) and arginase expression and the modulating role of 17β-estradiol (E2) on this phenomenon. Thirty oopherectomized rabbits were divided into three groups and treated for 15 weeks. Group I received normal chow; group II, HCD; and group III, HCD plus E2 pellets. Animals in group II showed an increase in plasma lipids, and they demonstrated atheromatous lesions as well as expression of arginase I and II accompanied by a significant number of BrdU-positive cells in endothelial cells and intimal muscle cells, suggestive of an increase in cellular proliferation. There was significant expression of inducible NOS and increased staining of nitrotyrosine-positive areas. These were not observed in group I animals. In both groups, E2 levels were low. In group III animals, E2 supplementation led to a decrease in atheromatous lesions and BrdU-positive cells and reduced expression of both inducible NOS and arginase I and II accompanied by a decrease in nitrotyrosine staining. E2 levels were increased. Our results suggest that E2 was responsible for these effects, despite the animals being hyperlipidemic, similar to those in group II. Because arginase is responsible for cell proliferation by converting l-arginine to polyamines, our results indicate that expression of arginase may play an important role in cellular proliferation in atherosclerosis, and inhibition of arginase expression by E2 may be another potential mechanism in attenuating atherogenesis.
Encryption with Access Control ∗

Outsourcing data to the cloud is becoming increasingly prevalent. To ensure data confidentiality, encrypting the data before outsourcing it is advised. While encryption protects the secrets in the data, it also prevents operations on the data. For example in a multi-user setting, data is often accessed via search, but encryption prevents search. Searchable encryption solves this dilemma. However, in a multi-user setting not all users may be allowed to access all data, requiring some means of access control. We address the question how searchable encryption and access control can be combined. Combining these technologies is required to achieve strong notions of confidentiality: if a ciphertext occurs as a search result, we learn something about the underlying document, even if access control does not let us access the document. This illustrates a need to link search and access control, so that search results presented to users only feature data the users are allowed to access. Our searchable encryption scheme with access control establishes that link.
Ambient‐Dried Cellulose Nanofibril Aerogel Membranes with High Tensile Strength and Their Use for Aerosol Collection and Templates for Transparent, Flexible Devices

The application potential of cellulose nanofibril (CNF) aerogels has been hindered by the slow and costly freeze‐ or supercritical drying methods. Here, CNF aerogel membranes with attractive mechanical, optical, and gas transport properties are prepared in ambient conditions with a facile and scalable process. Aqueous CNF dispersions are vacuum‐filtered and solvent exchanged to 2‐propanol and further to octane, followed by ambient drying. The resulting CNF aerogel membranes are characterized by high transparency (>90% transmittance), stiffness (6 GPa Young's modulus, 10 GPa cm3 g−1 specific modulus), strength (97 MPa tensile strength, 161 MPa m3 kg−1 specific strength), mesoporosity (pore diameter 10–30 nm, 208 m2 g−1 specific surface area), and low density (≈0.6 g cm−3). They are gas permeable thus enabling collection of nanoparticles (for example, single‐walled carbon nanotubes, SWNT) from aerosols under pressure gradients. The membranes with deposited SWNT can be further compacted to transparent, conductive, and flexible conducting films (90% specular transmittance at 550 nm and 300 Ω ◻−1 sheet resistance with AuCl3‐salt doping). Overall, the developed aerogel membranes pave way toward use in gas filtration and transparent, flexible devices.
Modeling of craton stability using a viscoelastic rheology

Archean cratons belong to the most remarkable features of our planet since they represent continental crust that has avoided reworking for several billions of years. Even more, it has become evident from both geophysical and petrological studies that cratons exhibit deep lithospheric keels which equally remained stable ever since the formation of the cratons in the Archean. Dating of inclusions in diamonds from kimberlite pipes gives Archean ages, suggesting that the Archean lithosphere must have been cold soon after its formation in the Archean (in order to allow for the existence of diamonds) and must have stayed in that state ever since. Yet, although strong evidence for the thermal stability of Archean cratonic lithosphere for billions of years is provided by diamond dating, the long-term thermal stability of cratonic keels was questioned on the basis of numerical modeling results. We devised a viscoelastic mantle convection model for exploring cratonic stability in the stagnant lid regime. Our modeling results indicate that within the limitations of the stagnant lid approach, the application of a sufficiently high temperature-dependent viscosity ratio can provide for thermal craton stability for billions of years. The comparison between simulations with viscous and viscoelastic rheology indicates no significant influence of elasticity on craton stability. Yet, a viscoelastic rheology provides a physical transition from viscously to elastically dominated regimes within the keel, thus rendering introduction of arbitrary viscosity cutoffs, as employed in viscous models, unnecessary.