Miracle-dz/UniFAR-FTUs huggingface dataset:
Experimental Study on the Property Degradation and Failure

Taking the weakly cemented sandstone of Ordos, China, as the research object, the evolution law between the relative stress of weakly cemented sandstone and themultiparameters of the acoustic emission under different dry-wet cycles was explored, and the critical failure identification mode of weakly cemented sandstone under dry-wet cycle was established. ,e results show that as the number of dry-wet cycles increases, the wave velocity loss rate gradually increases. Overall, the longitudinal wave loss rate is larger than the shear wave loss rate, indicating that the longitudinal wave is more sensitive to the degradation of weakly cemented sandstone. With an increase in the number of dry-wet cycles, the crack is mainly caused by the main crack penetration failure, and the secondary crack is significantly reduced. ,e fractal dimension decreases with an increase in the dry-wet cycles and reaches its maximum at 0 dry-wet cycles, which means that 0 dry-wet cycles witness the most complex morphology of fractures within the weakly cemented sandstone. ,is finding indicates that the dry-wet cycle inhibits the generation and expansion of fractures. ,e event rate appears to be close to 0 before the rupture, and then the platform oscillates, followed by a sudden increase. ,e acoustic emission b value is relatively high during the initial stage and then decreases, which is the initial damage process. ,e elastoplastic phase rises again, the peak stage decreases rapidly, and the weakly cemented sandstone undergoes unstable damage. ,e change in the acoustic emission entropy value is exactly the opposite of the b value change law. When the weakly cemented sandstone reaches the critical failure state under different dry-wet cycles, the relative stress value is 95%. ,e test results provide newmethods and a basis for the damage evolution mechanism and fracture prediction of weakly cemented sandstone under dry-wet cycles.
S TRESS -B ASED S PEECH S EGMENTATION R EVISITED

Although word stress is usually seen as a powerful speech-segmentation cue, the results of several cross-modal fragment priming experiments reveal strong limitations to stress-based segmentation. When stress was pitted against phonotactic and coarticulatory cues, substantial effects of the latter two cues were found, but there was no evidence for stress-based segmentation. However, when the stimuli were presented in a background of noise, the pattern of results reversed: Strong syllables generated more priming than weak ones, regardless of coarticulation and phonotactics. Furthermore, a similar dependency was found between stress and lexicality. Priming was stronger when the prime was preceded by a real than a nonsense word, regardless of the stress pattern of the prime. Yet, again, a reversal in cue dominance was oberved when the stimuli were played in noise. These results underscore the secondary role of stress-based segmentation in clear speech, and its efficiency in impoverished listening conditions. More generally, they call for an integrated, hierarchical, and signal-contingent approach to speech segmentation.
Do Corruption, Inflation and Unemployment Influence the Income Inequality of Developing Asian Countries?

Income inequality is one of the main issues influencing various economic aspects of nations. Thus, the current study aims to examine the dynamic role of corruption, inflation and unemployment on income inequality. For this purpose, 15 years balance panel data from 2006 to 2020 of 12 developing Asian countries is collected from the transparency international and World Bank Indicators (WDI) databases. Moreover, GINI Index which is used to measure the income inequality is considered as a variable of interest that indicates income inequality whereas, interest rate, corruption, inflation and unemployment are selected as independent variables. The Random Effect Model (REM) and Generalized Method of Moments (GMM) are used to examine the relationship among the selected variables. The results reveal that corruption, inflation and unemployment have a significant positive relationship with the GINI index hence, are core factors that increase the income inequality level in developing Asian countries. The results help to guide policymakers while formulating the regulations to control income inequality by focusing more on corruption, inflation and unemployment factors.
A GIS-based simulation and visualization tool for the assessment of gully erosion processes

ABSTRACT Gully erosion is known to affect soil productivity, and to limit land use in many parts of the world. To assess the susceptibility of soils to gully erosion, the triggering factors must be analyzed. A simulation of gully development over time was implemented in Python – GIS modules based on the topographic characteristics of the study area, soil properties, and measured runoff. The results show that the developed modules allow a successful data preparation, process simulation and spatial visualization of the obtained results in 2D and 3D as well as an analysis of time series of gully evolution .
TSPO PET Imaging as a Potent Non-Invasive Biomarker for Diffuse Intrinsic Pontine Glioma in a Patient-Derived Orthotopic Rat Model

Diffuse intrinsic pontine gliomas (DIPG), the first cause of cerebral pediatric cancer death, will greatly benefit from specific and non-invasive biomarkers for patient follow-up and monitoring of drug efficacy. Since biopsies are challenging for brain tumors, molecular imaging may be a technique of choice to target and follow tumor evolution. So far, MR remains the imaging technique of reference for DIPG, although it often fails to define the extent of tumors, an essential parameter for therapeutic efficacy assessment. Thanks to its high sensitivity, positron emission tomography (PET) offers a unique way to target specific biomarkers in vivo. We demonstrated in a patient-derived orthotopic xenograft (PDOX) model in the rat that the translocator protein of 18 kDa (TSPO) may be a promising biomarker for monitoring DIPG tumors. We studied the distribution of 18F-DPA-714, a TSPO radioligand, in rats inoculated with HSJD-DIPG-007 cells. The primary DIPG human cell line HSJD-DIPG-007 highly represents this pediatric tumor, displaying the most prevalent DIPG mutations, H3F3A (K27M) and ACVR1 (R206H). Kinetic modeling and parametric imaging using the brain 18F-DPA-714 PET data enabled specific delineation of the DIPG tumor area, which is crucial for radiotherapy dose management.
A NUMERICAL STUDY OF INFLUENCE OF INTERNAL CRACK ON THERMAL PROPERTY OF APS-TBCs

The internal crack initiation and propagation are decisive factors that dominates the failure of thermal barrier coatings under services. In this paper, TBCs samples with different crack lengths were numerically reconstructed. The temperature distribution characteristics of the surface and internal thermal barrier coatings were studied based on the coupled flow and heat transfer model of thermal barrier coatings and cooling film by using LBM-DDF method. The results show that the existence of cracks will greatly change the temperature distribution of the coating, resulting in increased temperature inhomogeneity and local sintering of the coating. This will lead to stress concentration, which can easily cause early delamination and fracture of the coating, thus affecting the durability of the coating. The results can provide a helpful reference for better technical support for life prediction of high temperature turbine blades.
Link prediction based on the naive Bayes with high-order clustering structure of node

Link prediction, a significant branch of complex networks, has attracted the attention of a growing number of scholars. It is an important tool in data mining. It is used to predict possible future links in the network or links that have not been observed yet. It can also be used to identify spurious links. The Local Naïve Bayes Model accurately distinguishes the contribution of different common neighbor nodes to the formation of the target link, but it only considers the contribution of common neighbors. A large number of networks have higher-order characteristics, and higher-order structures capture as much information about the network. In the work, we proposed a novel method of link prediction based on Naive Bayes with High-Order clustering structure (NBHO) of node. NBHO not only overcomes the shortcomings of the co-neighbor (common neighbor) similarity index that each co-neighbor of two nodes contributes equally to the likelihood of the connection, but also makes use of a higher order clustering structure. High-order structure plays an important role in the evolution of the network. Compared with the traditional method, this framework can provide more accurate predictions. Obviously there is a conclusion that the higher order structure significantly improves the accuracy of the predictions.
Noise Trader Risk and Wealth Effect: A Theoretical Framework

This paper discusses the impact of noise trader risk on total consumption and investor consumption. The model predicts that: (1) If noise traders show optimistic beliefs, they will have a restraining effect on the total consumption when the noise trading intensity is high enough, they will expand consumption at t = 1 and reduce consumption at t = 2, and rational investors will reduce consumption at t = 1 and expand consumption at t = 2; (2) if the beliefs of noise traders do not show bias, the consumption of rational investors is always higher than that of noise traders and exceeds the market benchmark; (3) the relative consumption of rational investors and noise traders depends on the risk, risk aversion, fundamental risk and market ratio of noise traders; (4) based on the reasonable range of noise traders’ beliefs, the lifetime consumption of noise traders will be higher than that of rational investors and the market, and the excess consumption will change with a series of parameters.
The Rise of the Urban Piety Movement: Jamaah Maiyah as an Urban Spiritualism and Emerging Religiosity in the Public Sphere

Recently, an intense discussion has developed among religion and social issues researchers on the discourse of spiritualism. The existence of spiritualism has changed parts of human civilization, including religious attitudes and expressions that exist in the public sphere. Therefore, in this study, the authors examined the discourse of spiritualism exemplified by Jamaah Maiyah Cak Nun. The model of spiritualism that the authors adopted was different in context from the cultural spiritualism studied by many scientists. This study sought to elaborate and explore the surge of religious spiritualism promoted by Jamaah Maiyah Cak Nun using a qualitative research framework. In addition, this research leads to a social and religious anthropological research model that combines virtual ethnography and fieldwork. The results of this study revealed the existence of spiritualism promoted by Jamaah Maiyah Cak Nun. Meanwhile, the development of various models of different aspects of spiritualism could not be separated from the support of the community itself. The Jamaah Maiyah's interaction also deserved attention; universal religious expressions and egalitarianism were the domains of the community. This research should be a reference for developing religious and social discourse in the future.
A Clinically Significant Prostate Cancer Predictive Model Using Digital Rectal Examination Prostate Volume Category to Stratify Initial Prostate Cancer Suspicion and Reduce Magnetic Resonance Imaging Demand

Simple Summary Early detection of PCa (PCa) has evolved towards clinically significant PCa (csPCa) after the spread of pre-biopsy multiparametric magnetic resonance imaging (mpMRI). However, PCa suspicion remains based on prostate-specific antigen (PSA) elevation and/or abnormal digital rectal examination (DRE). This change of paradigm and approach has reduced unnecessary prostate biopsies and overdetection of insignificant PCa, while the demand for mpMRI has skyrocketed despite its implementation not being allowed at all sites. The European Association of Urology (EAU) proposes risk-organized models for early detection of csPCa stratifying the initial PCa suspicion to reduce MRI scans and then prostate biopsies after mpMRI. Risk calculators are efficient tools for individualizing the risk of csPCa, especially when prostate volume is included in the predictive models. After the development and external validation of the Barcelona MRI risk calculator (BCN-RC 2) for the selection of candidates for prostate biopsy, we have now developed and externally validated BCN-RC 1 with the aim of reduce mpMRI demand. Both BCN-RC 1 and RC 2 are ready to be integrated in a risk-organized model for early detection of csPCa. Abstract A predictive model including age, PCa family history, biopsy status (initial vs repeat), DRE (normal vs abnormal), serum prostate-specific antigen (PSA), and DRE prostate volume ca-tegory was developed to stratify initial PCa suspicion in 1486 men with PSA > 3 ng/mL and/or abnormal DRE, in whom mpMRI followed; 2- to 4-core TRUS-guided biopsies where Prostate Imaging Report and Data System (PI-RADS) > 3 lesions and/or 12-core TRUS systematic biopsies were performed in one academic institution between 1 January 2016–31 December 2019. The csPCa detection rate, defined as International Society of Uro-Pathology grade group 2 or higher, was 36.9%. An external validation of designed BCN-RC 1 was carried out on 946 men from two other institutions in the same metropolitan area, using the same criteria of PCa suspicion and diagnostic approach, yielded a csPCa detection rate of 40.8%. The areas under the receiver operating characteristic curves of BCN-RC 1 were 0.823 (95% CI: 0.800–0.846) in the development cohort and 0.837 (95% CI: 0.811–0.863) in the validation cohort (p = 0.447). In both cohorts, BCN-RC 1 exhibited net benefit over performing mpMRI in all men from 8 and 12% risk thresholds, respectively. At 0.95 sensitivity of csPCa, the specificities of BCN-RC 1 were 0.24 (95% CI: 0.22–0.26) in the development cohort and 0.34 (95% CI: 0.31–0.37) in the validation cohort (p < 0.001). The percentages of avoided mpMRI scans were 17.2% in the development cohort and 22.3% in the validation cohort, missing between 1.8% and 2% of csPCa among men at risk of PCa. In summary, BCN-RC 1 can stratify initial PCa suspicion, reducing the demand of mpMRI, with an acceptable loss of csPCa.
The complexity of spherical p-spin models - a second moment approach

Recently, Auffinger, Ben Arous, and \v{C}ern\'y initiated the study of critical points of the Hamiltonian in the spherical pure $p$-spin spin glass model, and established connections between those and several notions from the physics literature. Denoting the number of critical values less than $Nu$ by $\mbox{Crt}_{N}(u)$, they computed the asymptotics of $\frac{1}{N}\log(\mathbb{E}\mbox{Crt}_{N}(u))$, as $N$, the dimension of the sphere, goes to $\infty$. We compute the asymptotics of the corresponding second moment and show that, for $p\geq3$ and sufficiently negative $u$, it matches the first moment: \[ \mathbb{E}\left\{ \left(\mbox{Crt}_{N}\left(u\right)\right)^{2}\right\} /\left(\vphantom{\left(\mbox{Crt}_{N}\left(u\right)\right)^{2}}\mathbb{E}\left\{ \mbox{Crt}_{N}\left(u\right)\right\} \right)^{2}\to1. \] As an immediate consequence we obtain that $\mbox{Crt}_{N}(u)/\mathbb{E}\{ \mbox{Crt}_{N}(u)\} \to 1$, in $L^2$ and thus in probability. For any $u$ for which $\mathbb{E}\mbox{Crt}_{N}(u)$ does not tend to $0$ we prove that the moments match on an exponential scale.
Development of WRAP5 Peptide Complexes for Targeted Drug/Gene Co-Delivery toward Glioblastoma Therapy

Despite the great progress over the past few decades in both the diagnosis and treatment of a great variety of human cancers, glioblastoma remains the most lethal brain tumor. In recent years, cancer gene therapy focused on non-viral vectors which emerged as a promising approach to glioblastoma treatment. Transferrin (Tf) easily penetrates brain cells of the blood–brain barrier, and its receptor is highly expressed in this barrier and glioblastoma cells. Therefore, the development of delivery systems containing Tf appears as a reliable strategy to improve their brain cells targeting ability and cellular uptake. In this work, a cell-penetrating peptide (WRAP5), bearing a Tf-targeting sequence, has been exploited to condense tumor suppressor p53-encoding plasmid DNA (pDNA) for the development of nanocomplexes. To increase the functionality of developed nanocomplexes, the drug Temozolomide (TMZ) was also incorporated into the formulations. The physicochemical properties of peptide/pDNA complexes were revealed to be dependent on the nitrogen to phosphate groups ratio and can be optimized to promote efficient cellular internalization. A confocal microscopy study showed the capacity of developed complexes for efficient glioblastoma cell transfection and consequent pDNA delivery into the nucleus, where efficient gene expression took place, followed by p53 protein production. Of promise, these peptide/pDNA complexes induced a significant decrease in the viability of glioblastoma cells. The set of data reported significantly support further in vitro research to evaluate the therapeutic potential of developed complexes against glioblastoma.
Fitting Models to Biological Data Using Linear and Nonlinear Regression: A Practical Guide to Curve Fitting

FITTING DATA WITH NONLINEAR REGRESSION FITTING DATA WITH LINEAR REGRESSION MODELS HOW NONLINEAR REGRESSION WORKS CONFIDENCE INTERVALS OF THE PARAMETERS COMPARING MODELS HOW DOES A TREATMENT CHANGE THE CURVE? FITTING RADIOLIGAND AND ENZYME KINETICS DATA FITTING DOES-RESPONSE CURVES FITTING CURVES WITH GRAPHPAD PRISM
THE ENCOURAGEMENT OF ERGO-ICONIC SERVICE VALUES TOWARD AGILE GOVERNMENT TO IMPROVE THE GOVERNMENT SERVICE PERFORMANCE

This research aims to prove that government services adopting an ergo-iconic service can improve their services, their existence to think, become entrepreneurial government, build, and create innovative ideas. This research used e-questionnaires distributed using snowball sampling technique. There were 202 respondents collected in a month, 20 days on February to March in 2020. The questionnaires distributed through online media could limit the respondents to give their answers. If they are under 20 years old or same as those who have graduated from college, it could be assumed that they often do transactions service provided by the government. Ergo-iconic service values proposed in this research was used as the independent variable. This is proven to contribute positively and encourage agile government improvement and acceptance of community values. In addition, ergo-iconic values are able to touch and provide comfortable functions that succeed in improving government service performance. The originality of indicators in this research is ergo-iconic service values developed from previous researches. The implication of this research results is that the model of ergo-iconic service values can create public service performance and realize agile government
Characteristics and application of present in situ stress field of a strike-slip fault: a 3D finite-element simulation study

Abstract Previous hydrocarbon explorations in the middle of the Tarim Basin indicate that strike-slip faults play an important role in the development of Ordovician carbonate reservoirs and hydrocarbon accumulation. The SB5 fault in the Tarim Basin was the target of this investigation. An evaluation of the stress in situ was carried out and provided boundary conditions to build a 3D geomechanical model. The distribution and application of present in situ stress in the strike-slip fault were studied. The results show good agreement between the absolute measured stress in situ and the modelled stresses, revealing a different stress regime along the strike-slip fault. The uplift segment belongs to a strike-slip stress state, and other areas belong to a normal fault stress state. The strike-slip fault has a significant influence on the present in situ stress distribution. The direction of the maximum horizontal stress deflects near the fault and tends to be parallel to the fault strike. This work introduces a comprehensive evaluation of the present in situ stress of the fractured carbonate reservoirs controlled by the strike-slip fault system. The present in situ stress direction can clarify the propagation direction of hydraulic fracturing and serve to evaluate the effectiveness of natural fractures.
Enhanced SIMO Radar System Based on Time-Frequency Correlation for Target Localization Applications

This study developed a novel S-band radar system for planar location applications. High-resolution range imaging and target angle estimation were achieved by using a stepped frequency continuous wave (SFCW) signal and single input multiple output (SIMO) architecture with a linear sparse array layout, respectively. An improved time-frequency method was utilized to link the inde-pendent range profile and angle spectrum results to obtain the plane positions of the targets. The radar hardware was composed of the antenna array with one transmit element and five receive elements, an RF transceiver, and a signal processing component. Under the proposed waveform parameters and signal processing scheme, a 16-ms process cycle, 0.3-m ranging error, and 0.4° angle estimation error for target positioning were achieved in field tests. These results demonstrate the effectiveness and advantages of the proposed radar system.
Prevalence of stunting and determinants of growth failure in children with Type 1 diabetes

Objectives: India is home to the highest number of prevalent cases of Type-1 diabetes (T1D) in children. There is scarcity of data on the growth failure of children with diabetes, especially those having complications and comorbidities, thus, we conducted this study with the objective to determine the prevalence and predictors of stunting in children with T1D. Methods: This cross-sectional study included 350 children and adolescents aged 1–18 years with T1D. Demographic data, anthropometry, diet, sexual maturity rating, and biochemical measurements were performed using standard protocols. Short stature was defined as height for age Z-score <−2. p<0.05 was considered statistically significant. Results: We report a 15.7% prevalence of stunting in our cohort of children with T1D. Stunted children had higher cholesterol, lower hemoglobin, lower mid-parental height Z-scores, and higher urinary albumin creatinine ratio. Binary logistic regression revealed that pre-existing comorbidities, compromised renal function, longer disease duration, and short mid-parental height were significant predictors of stunting. Conclusion: A little under one-sixth of children with T1D had short stature. Monitoring growth in these patients, especially in subjects with short parents, prolonged duration of diabetes, existing comorbidities, and deteriorating renal function are critical.