Miracle-dz/UniFAR-FTUs huggingface dataset:
A Coevolving Systems Approach to the Organization of Agile Software Development

Despite the popularity of agile methods in software development and increasing adoption by organizations there is debate about what agility is and how it is achieved. The debate suffers from a lack of understanding of agile concepts and how agile software development is practised. This paper develops a framework for the organization of agile software development that identifies enablers and inhibitors of agility and the emergent capabilities of agile teams. The work is grounded in complex adaptive systems (CAS) and draws on three principles of coevolving systems: match coevolutionary change rate, maximise self-organizing, and synchronize exploitation and exploration. These principles are used to study the processes of two software development teams, one a team using eXtreme Programming (XP) and the other a team using a more traditional, waterfall-based development cycle. From the cases a framework for the organisation of agile software development is developed. Time pacing, self-management with discipline and routinisation of exploration are among the agile enablers found in the cases studies while event pacing, centralised management and lack of resources allocated to exploration are found to be inhibitors to agility. Emergent capabilities of agile teams that are identified from the research include coevolution of business value, sustainable working with rhythm, sharing and team learning, and collective mindfulness.
HIGH-LIFT NOISE REDUCTION USING PLASMA ACTUATORS

During the approach, high-lift devices are among the major sources of aircraft noise. Most of the current solutions are based on passive ﬂow control technologies, which are reaching a limit of their noise reduction performance. Thus, devices based on active ﬂow control may allow for additional improvements. One way of doing active ﬂow control is through the use of dielectric barrier discharge plasma actuators. These devices produce a wall jet by ionizing and accelerating the air nearby through an intense electric ﬁeld. In this research, dielectric barrier discharge plasma actuators were installed at a ﬂap rounded tip (to reduce the strength of the side-edge vortices), at the cove and the cusp of a leading-edge slat (to change the shear layer behavior). A parametric study was carried out varying plasma actuator geometry, plasma actuator position of installation, voltage, frequency, duty cycle, and modulation frequency. Far-ﬁeld acoustic array and surface pressure measurements in a wind tunnel were conducted and the results demonstrated the potential of plasma actuators for high-lift noise reduction. A decrease of up to 0.75 dB in the overall ﬂap noise and up to 3.3 dB in the overall slat noise (with 12 dB of reduction in the dominant tonal peak) were achieved by using the plasma actuators. However, many conﬁgurations were not able to reduce or even has increased the overall noise, evidencing the need of proper optimization of the plasma actuator geometry, materials, and operational parameters to improve the control authority of these devices.
Activation of Wnt signaling promotes olaparib resistant ovarian cancer

Epithelial ovarian cancer (EOC) has one of the highest death to incidence ratios among all cancers. High grade serous ovarian carcinoma (HGSOC) is the most common and deadliest EOC histotype due to the lack of therapeutic options following debulking surgery and platinum/taxane‐based chemotherapies. For recurrent chemosensitive HGSOC, poly(ADP)‐ribose polymerase inhibitors (PARPi; olaparib, rucaparib, or niraparib) represent an emerging treatment strategy. While PARPi are most effective in homologous recombination DNA repair‐deficient (HRD) HGSOCs, recent studies have observed a significant benefit in non‐HRD HGSOCs. However, all HGSOC patients are likely to acquire resistance. Therefore, there is an urgent clinical need to understand PARPi resistance and to introduce novel combinatorial therapies to manage PARPi resistance and extend HGSOC disease‐free intervals. In a panel of HGSOC cell lines, we established matched olaparib sensitive and resistant cells. Transcriptome analysis of the matched olaparib‐sensitive vs ‐resistant cells revealed activation of the Wnt signaling pathway and consequently increased TCF transcriptional activity in PARPi‐resistant cells. Forced activation of canonical Wnt signaling in several PARPi‐sensitive cells via WNT3A reduced olaparib and rucaparib sensitivity. PARPi resistant cells were sensitive to inhibition of Wnt signaling using the FDA‐approved compound, pyrvinium pamoate, which has been shown to promote downregulation of β‐catenin. In both an HGSOC cell line and a patient‐derived xenograft model, we observed that combining pyrvinium pamoate with olaparib resulted in a significant decrease in tumor burden. This study demonstrates that Wnt signaling can mediate PARPi resistance in HGSOC and provides a clinical rationale for combining PARP and Wnt inhibitors.
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When responding to external stimuli, preparation reduces Reaction Time (RT). One form of preparation known as temporal preparation results from advance knowledge about when a stimulus will appear. We used Event Related Potentials to investigate how increasing temporal preparation decreases RT during a speeded, choice RT task by manipulating temporal preparation within subjects. In order to determine which cognitive processes are speeded, the latencies of the Lateralized Readiness Potential (LRP) and P300 were examined across two levels of temporal preparation. In line with previous research the stimulus locked LRP, but not the response locked LRP, was speeded when temporal preparation was high. Using Principal Component Analysis, we also found that the P300 latency was reduced by nearly the same extent as RT was reduced. These findings suggest that temporal preparation speeds stimulus evaluation processing specifically, and this explains to a large extent how temporal preparation reduces RT.
EFFECT OF PLANT GROWTH REGULATORS AND ORGAN TYPE ON CALLUS INDUCTION, GROWTH DYNAMIC, POLYPHENOL, FLAVONOID AND TANNIN CONTENT IN MILK THISTLE ( SILYBUM MARIANUM L.

Milk thistle ( Silybum marianum L. Gaertn., Asteraceae) is an annual or biennial, broadleaf plant native in North African and Mediterranean with highly valued medicinal properties. The active compound in S. marianum is silymarin; which is an isomeric mixture of flavonolignans which used in pharmaceutical industries. Milk thistle is the most commonly used herbal product for chronic liver disease and may be beneficial for reducing the chances for developing certain cancers. Plant secondary metabolites, which have been extracted from in vivo grown plants, were used for a long time but the general trend new is to extract these secondary metabolites from in vitro grown plants. We cannot ignore the importance of using tissue culture techniques which gives the ease of almost all of plant researches, also there are so many other reasons such as protection from weather and from diseases, pests, soil problems and obtaining mass quantities with low cost. As obtaining secondary metabolites from milk thistle plants is considered a tedious process, it became clear that replacing this by obtaining these products from in vitro might be better, so our successful attempt was made to produce calluses and extract the active ingredients from them. The result of the experiment showed that significances differences were found in the influence of organ and medium type on callus initiation, growth dynamic and chemical content from polyphenol,
Causes and Effects of Shisper Glacial Lake Outburst Flood Event Causes and Effects of Shisper Glacial Lake Outburst Flood Event in Karakoram in 2022 in Karakoram in 2022

Karakoram Himalayas are vulnerable to glacial lake outburst floods (GLOFs), which cause catastrophic floods in the surrounding areas. The increasing natural and anthropogenic activities, especially in the Indo-Gangetic Plains at the southern flank of the towering Himalayas, could be the cause of climate change affecting the frequency of the natural hazards in the Himalayas. In the present study, a detailed analysis of the Shisper Lake breach of 7 May 2022 is carried out using satellite remote sensing. A decreasing trend in the glacial mass balance is observed between 2017 and 2021; in this period, frequent GLOF episodes occurred. A pronounced decline in the snow cover and glacial debris (before the cascade) and an abnormal increase in land surface temperature (LST) retrieved from satellite data could be responsible for the enhanced snow/glacial melting prior to the breach. Alteration in glacial mobility (cm/12days) is observed at the locations where the glacier melts due to an increase in LST with increased debris cover. In the paper, we have studied changes in water quality and land cover along the stream after the GLOF. An increment in normalized difference turbidity index (NDTI) is observed before the flood showing turbulence and sediment load. Increased glacial melt contribution into the stream results in increased flow rate and decreased water quality as observed through normalized difference water index (NDWI) and normalized difference chlorophyll index (NDCI), near the Karakoram Highway Bridge. Sentinel-1 backscatter coefficient indicates increased discharge from the melting of glaciers. A significant reduction in co-flood coherence is observed, attributed to the bridge collapse and severe bank erosion.
Beyond Limits: Envisioning Sustainable Design and Production Ecosystems

The use of sustainability is of utmost importance when it comes to tackling the environmental issues that our global community is currently confronting, ranging from climate change to the depletion of natural resources. The publication titled “Beyond Limits: Envisioning Sustainable Design and Production Ecosystems” delves into the imperative need for a paradigm shift in order to effectively address the aforementioned difficulties. This paradigm shift necessitates a break from conventional, sequential frameworks towards circular and regenerative systems, signifying a fundamental shift in our design and production methodologies. The concept of sustainable design and production ecosystems is intrinsically characterised by its complex nature. The dimensions encompassed by these practises are broad, encompassing the reimagining of design processes, the careful selection of materials, the optimisation of production procedures, the rethinking of supply chain management, and the consideration of end-of-life scenarios. Each of these characteristics plays a crucial role in establishing a comprehensive and enduring environment. The fundamental objective of this notion is to develop a state of peaceful coexistence between human activities and the ecosystems of the earth. In addition to the reduction of harm, it promotes active engagement in activities that contribute to the overall welfare of our environment. By exploring this paradigm-shifting perspective, we establish the foundation for a forthcoming era in which human pursuits harmoniously integrate with the ecological systems of the Earth, ensuring a sustainable and wealthy global community for future generations.
Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology (PARDIE): an international observational study

Background: Pediatric Acute Respiratory Distress Syndrome (PARDS) occurs frequently in children, but until recently there were no pediatric specific diagnostic criteria. The Pediatric Acute Lung Injury Consensus Conference (PALICC) definition was developed to overcome limitations of the Berlin definition in children, but the incidence and outcomes of children who meet this definition are unclear. Methods: Prospective, observational, cross-sectional study amongst invasively (IMV) or non-invasively (NIV) ventilated children with PARDS in a participating pediatric intensive care unit (PICU) during 10 study weeks. Findings: From 145 international PICUs, new PARDS occurred in 744 children (3.2% of PICU patients). 708 had complete data for analysis, with 17.1% mortality. Only 32% met Berlin criteria at PARDS diagnosis, and had higher severity of illness, different PARDS triggers and comorbidities, and more cardiac dysfunction than the larger PARDS cohort. Based on hypoxemia severity at PARDS onset, mortality was similar amongst NIV, mild, or moderate PARDS (10– 15%), but higher for severe PARDS (33%). Half of NIV PARDS patients were subsequently intubated, with 25% mortality. PARDS severity 6 hours after initial diagnosis discriminates PICU mortality (AUC 0.689 (95%CI 0.624, 0.754)) better than at PARDS diagnosis, and outperforms Berlin hypoxemia categories (0.639 (0.575, 0.703), p=0.01). Adjusted mortality is nearly 3 times higher for those with severe PARDS or those from a low/middle-income country. of PICU patients internationally. The definition identifies many more children with ARDS than the Berlin definition, and PARDS severity groupings stratify mortality risk, particularly when applied 6 hours after PARDS diagnosis.
Incentive-Aware Synthetic Control: Accurate Counterfactual Estimation via Incentivized Exploration

We consider the setting of synthetic control methods (SCMs), a canonical approach used to estimate the treatment effect on the treated in a panel data setting. We shed light on a frequently overlooked but ubiquitous assumption made in SCMs of"overlap": a treated unit can be written as some combination -- typically, convex or linear combination -- of the units that remain under control. We show that if units select their own interventions, and there is sufficiently large heterogeneity between units that prefer different interventions, overlap will not hold. We address this issue by proposing a framework which incentivizes units with different preferences to take interventions they would not normally consider. Specifically, leveraging tools from information design and online learning, we propose a SCM that incentivizes exploration in panel data settings by providing incentive-compatible intervention recommendations to units. We establish this estimator obtains valid counterfactual estimates without the need for an a priori overlap assumption. We extend our results to the setting of synthetic interventions, where the goal is to produce counterfactual outcomes under all interventions, not just control. Finally, we provide two hypothesis tests for determining whether unit overlap holds for a given panel dataset.
A novel three-layer architecture for information system integration

— The purpose of Information System Integration (ISI) is to streamline business processes by synchronized or asynchoronized completion of a series of steps. Integration architects use the so called “integration layer” as a methodology to accomplish such tasks. To date, in the literature, three kinds of layer mechanisms are reported: No (Point-to-Point), One (Message Brokers), and Two (Message Bus). Although these three kind of layer types can solve most of the integration challenges, among them there are both design and run-time quality challenges. In this paper, a new type of layering, named “Three integration layers” is introduced to improve the quality of the integration solutions. Also, this paper argues that new integration layers can be used for ISI projects to improve IS integration quality.
Automotive 2.1 μm Full-Depth Deep Trench Isolation CMOS Image Sensor with a 120 dB Single-Exposure Dynamic Range

An automotive 2.1 μm CMOS image sensor has been developed with a full-depth deep trench isolation and an advanced readout circuit technology. To achieve a high dynamic range, we employ a sub-pixel structure featuring a high conversion gain of a large photodiode and a lateral overflow of a small photodiode connected to an in-pixel storage capacitor. With the sensitivity ratio of 10, the expanded dynamic range could reach 120 dB at 85 °C by realizing a low random noise of 0.83 e- and a high overflow capacity of 210 ke-. An over 25 dB signal-to-noise ratio is achieved during HDR image synthesis by increasing the full-well capacity of the small photodiode up to 10,000 e- and suppressing the floating diffusion leakage current at 105 °C.
Incorporation of chlorine in nuclear waste glasses using high-pressure 2 vitrification: Solubility, speciation and local environment of chlorine

The solubility, speciation and local atomic environment of chlorine have been determined for 27 aluminoborosilicate glasses quenched from high-pressure (0.5-1.5 GPa) and high-temperature 28 (1350-1400°C) equilibrated with various sources of chlorine (NaCl and PdCl 2 ). The Cl 29 solubility reaches up to 11 mol. % in borosilicate glass and appears to be strongly influenced 30 by the concentration of network modifying cations (Ca and Na) and increases with increasing 31 CaO + Na 2 O content. The Cl solubility is enhanced in Ca-bearing rather than Na-bearing 32 borosilicate glass, suggesting a higher affinity of chlorine for alkaline-earth cations. Cl K- 33 edge XANES and Cl 2p XPS spectra reveal that chlorine dissolves in glasses only as chloride 34 species (Cl - ) and no evidence of oxidized species is observed. Using PdCl 2 as a chlorine 35 starting source leads to pre-edge signal for PdCl 2 in the XANES spectra. The EXAFS 36 simulations show that Cl - local environment is charge compensated by Na + or Ca 2+ at a 37 distance to first neighbor on the order of 2.7 Å that is comparable to the observed distances in 38 chlorine crystalline compounds. The coordination to charge compensating cation is lower in 39 the case of Ca 2+ (~1.1) than Na + (~4.3). 40
Identification of Single Nucleotide Polymorphisms for Small Ruminant Health and Adaptation

Production of small ruminant animals has increased globally in part because of increasing demand for meat and milk. According to the UN’s Food and agricultural organization (FAO), the estimated world’s population will approach 10 billion by the year 2050. Furthermore, the economic status of people in developing nations is improving. Therefore, increased production is required to meet nutritional requirements for food and fiber. There is a need to reduce the environmental impact and use of ineffective antibiotics and anthelmintics. Genomic tests, precision agriculture technologies in breeding, feeding or health drive sustainable productivity and treatment solutions. Genetic variation contributes to natural resistance and resilience of sheep and goats against parasites. Definition of genetic variation and understanding signatures of natural selection and association with disease is the best long-term solution and a benchmark to help improve breeds. Progress in genomics is allowing us to determine genetic variation at the whole animal level. Using Single Nucleotide Polymorphisms (SNP) analysis is a less costly approach to determine within breed or species variation between animals and adaption to an environment. It is important to identify immune gene variants that modulate host-pathogen interactions and are responsible for small ruminant health and immunity. We investigated SNP variants in selected genes related to innate immunity (Toll like receptors TLR and Galectins, LGALS) on 88 Ethiopian sheep genotyped with Ovine Infinium HD SNP BeadChip (600K) and 308 Chinese goats genotyped with Illumina Goat 50K BeadChip. An in-Silico approach with Ensembl database and SNP Chips was used to determine minor allele frequency. We identified 86 TLR and 19 LGALS SNP from sheep and 1 LGALS SNP in goats with variable minor allele frequency ( MAF) level. This new knowledge and the SNP analysis approach can increase prediction of sheep and goat innate immunity and adaptation to control diseases for sustainable production.
Diffusion-Relaxation Correlation Spectroscopic Imaging (DR-CSI): An Enhanced Approach to Imaging Microstructure

Synopsis We propose a new MR experiment called diffusion-relaxation correlation spectroscopic imaging (DR-CSI). DR-CSI acquires imaging data across a range of different b-value and echo time combinations, and then performs regularized reconstruction to generate a 2D diffusion-relaxation correlation spectrum for every voxel. The peaks of this spectrum correspond to the different tissue microenvironments that are present within each macroscopic imaging voxel, which provides powerful insight into the tissue microstructure. Compared to standard relaxometry or diffusion imaging, DR-CSI provides unique capabilities to resolve tissue compartments that have similar relaxation or diffusion parameters. DR-CSI is demonstrated with spinal cord traumatic injury MRI data.
Jelly pineapple syneresis assessment via univariate and multivariate analysis.

The evaluation of the pineapple jelly is intended to analyze the occurrence of syneresis by univariate and multivariate analysis. The jelly of the pineapple presents low concentration pectin, therefore, it was added high methoxyl pectin in the following concentrations: 0.50%, 0.75% and 1.00% corresponding to slow, medium and fast speed of gel formation process. In this study it was checked the pH, acidity, brix and the syneresis of jelly. The highest concentration of pectin in the jelly showed a decrease in the release of the water, syneresis. This result showed that the percentage of 1.00% of pectin in jelly is necessary to form the gel and to obtain a suitable texture. Key-words: Chemical analysis. Syneresis. Cluster analysis. 1Enga. Alimentos e Mestre em Tecnologia de Alimentos, Universidade Federal do Parana, Curitiba – PR. E-mail: siolico@yahoo.com. br 2Enga. Quimica e Docente do Departamento Engenharia Quimica da UFPR. E-mail: arislete@ufpr.br 3Enga. Agronoma e Pesquisadora da Embrapa Floresta, Colombo – PR. E-mail: catie.godoy@gmail.com 4Eng. Agronomo e Pesquisador da Embrapa Mandioca e Fruticultura Tropical, Cruz das Almas – BA.E-mail: ledo@cnpmf.embrapa. br
Chapman University Digital Commons Chapman University Digital Commons

: The effects of methylene blue (MB) on cromakalim-induced K + currents were investigated in follicle-enclosed Xenopus oocytes. In concentrations ranging from 3–300 µ M, MB inhibited K + currents (IC 50 : 22.4 µ M) activated by cromakalim, which activates K ATP channels. MB inhibited cromakalim-activated K + currents in a noncompetitive and voltage-independent manner. The respective EC 50 and slope values for cromakalim-activation of K + currents were 194 ± 21 µ M and 0.91 for controls, and 206 ± 24 µ M and 0.87 in the presence of 30 µ M MB. The inhibition of cromakalim-induced K + currents by MB was not altered by pretreatment with the Ca 2+ chelator BAPTA, which suggests that MB does not inﬂuence Ca 2+ -activated second messenger pathways. K + currents mediated through a C-terminally deleted form of Kir6.2 (Kir ∆ C26), which does not contain the sulfonylurea receptor, were still inhibited by MB, indicating direct interaction of MB with the channel-forming Kir6.2 subunit. The binding characteristics of the K ATP ligand [ 3 H]glibenclamide are not altered by MB in a concentration range between 1 µ M-1 mM, as suggested by radioligand binding assay. The presence of a membrane permeable cGMP analogue (8-Br-cGMP, 100 µ M) and a guanylate cyclase activator (BAY 58-2667, 3 µ M) did not affect the inhibitory effects of MB, suggesting that MB does not inhibit cromakalim-activated K + currents through guanylate cyclase. Collectively, these results suggest that MB directly inhibits cromakalim-activated K + currents in follicular cells of Xenopus oocytes.