Miracle-dz/UniFAR-FTUs huggingface dataset:
Alleviate chip I/O pin constraints for multicore processors through optical interconnects

Chip I/O pins are an increasingly limited resource and significantly affect the performance, power and cost of multicore processors. Optical interconnects promise low power and high bandwidth, and are potential alternatives to electrical interconnects. This work systematically developed a set of analytical models for electrical and optical interconnects to study their structures, receiver sensitivities, crosstalk noises, and attenuations. We verified the models by published implementation results. The analytical models quantitatively identified the advantages of optical interconnects in terms of bandwidth, energy consumption, and transmission distance. We showed that optical interconnects can significantly reduce chip pin counts. For example, compared to electrical interconnects, optical interconnects can save at least 92% signal pins when connecting chips more than 25 cm (10 inches) apart.
Aspergillus terreus Accessory Conidia Are Unique in Surface Architecture, Cell Wall Composition and Germination Kinetics

Infection with Aspergillus terreus is more likely to result in invasive, disseminated disease when compared to other Aspergillus species; importantly this species appears to be less susceptible to the antifungal drug amphotericin B. Unique to this species is the ability to produce specialized structures denoted as accessory conidia (AC) directly on hyphae both in vitro and in vivo. With the hypothesis that production of AC by A. terreus may enhance virulence of this organism, we analyzed the phenotype, structure and metabolic potential of these conidia. Comparison of A. terreus phialidic conidia (conidia that arise from conidiophores, PC) and AC architecture by electron microscopy revealed distinct morphological differences between the two conidial forms; AC have a smoother, thicker outer cell surface with no apparent pigment-like layer. Further, AC germinated rapidly, had enhanced adherence to microspheres, and were metabolically more active compared to PC. Additionally, AC contained less cell membrane ergosterol, which correlated with decreased susceptibility to AMB as determined using a flow cytometry based analysis. Furthermore, AC exhibited surface patches of β1-3 glucan, suggestive of attachment scarring. Collectively, the findings of this study suggest a possible role for AC in A. terreus pathogenesis.
Optimising pulsed current TIG welding parameters to refine the fusion zone

The use of pulsed current parameters has been found to improve the mechanical properties of high strength Al–Zn–Mg–Cu welds compared to those of continuous current welds. This is due to grain refinement occurring in the fusion zone. In this investigation an attempt has been made to optimise pulsed current TIG welding parameters to attain maximum grain refinement in high strength AA 7075 aluminium alloy using statistical tools such as design of experiments, response table, and analysis of variance techniques.
Temporal Analysis of Online Social Graph by Home Location

An online social graph which represents relationships between users is used for many purposes such as home location estimation. However, the online social graph changes over time because the user’s environment changes (e.g., house-moving). We tackle temporal analysis of online social graphs by answering the following question: which social graph of certain periods shows the best performance for network-based home location estimation on Twitter? We obtain that the estimation performance achieves the best using the social graph after about half a year. This result indicates that changes in social graphs due to user’s environmental changes converge after about half a year. ACM Classification
Two-hop Free-space based optical interconnects for chip multiprocessors

Many resources are shared among the cores of chip-multiprocessors (CMPs), in particular on-chip caches and memory systems. Efficient intra-chip communication is necessary for efficient resource sharing and the performance of such systems, especially in future CMPs with hundreds or thousands of cores. Current Free-space optical networks-on-chip (NoCs) provide the potential to avoid the reduced wire performance and degraded signal integrity facing electronic networks. However, current proposals utilize fixed direction lasers and mirrors to realize one-hop all-to-all connectivity, which results in difficulties scaling to larger numbers of processors. In this paper we present two-hop optical strategies that provide better performance over the one-hop strategy while improving on both the required resources and scalability for future large scale CMPs.
Metabolic risk with second-generation antipsychotic treatment: a double-blind randomized 8-week trial of risperidone and olanzapine.

BACKGROUND The second-generation antipsychotics are effective for treating psychotic disorders and incur fewer motor side effects than are commonly experienced with the use of first-generation antipsychotics. However, their use is commonly associated with weight gain and metabolic disturbances. This study examined weight and metabolic changes with two widely used antipsychotics, risperidone and olanzapine; addressing the issue of early monitoring for metabolic side effects. METHODS This 8-week double blind randomized trial included patients with schizophrenia or schizoaffective disorder (N = 377) randomly assigned to risperidone (2-6 mg/day) or olanzapine (5-20 mg/day). Weight, BMI, HbA1C, total cholesterol (TC), LDL-C, HDL-C and triglycerides (TG) were monitored. RESULTS Mean BMI increases were higher in the olanzapine group as compared to risperidone (1.3 kg/m(2)(SD = 0.13) vs. 0.7 kg/m(2) (SD = 0.13)(p < 0.001). Increases in mean TC (13.5 mg/dl (SD 2.4), LDL-C (11.0 mg/dl (SD 2.2)) and TG (14.8 mg/dl (SD = 7.6)) occurred in the olanzapine group while significant changes in TC (-3.9 mg/dl (SD = 2.5)) and TG (-32.8 mg/dl (SD = 7.8)) were noted in the risperidone group. Men (not women) on olanzapine had higher than expected increases in lipids given the amount of weight gain. Baseline values and prior therapy did not contribute to the significant differences, however BMI increases (p = 0.0002) were linked to study discontinuation in both drug groups. CONCLUSIONS The fact that significant metabolic changes occurred (both positive and negative) in eight weeks is important to clinical care. Monitoring for metabolic changes may be important within the first eight weeks of treatment, as changes can be determined very early in antipsychotic treatment.
Acoustic Wave Sensors Theory Design And Physico Chemical Applications

Thank you for reading acoustic wave sensors theory design and physico chemical applications. Maybe you have knowledge that, people have search numerous times for their favorite books like this acoustic wave sensors theory design and physico chemical applications, but end up in harmful downloads. Rather than enjoying a good book with a cup of coffee in the afternoon, instead they cope with some harmful bugs inside their computer.
Research on Synthetic Aperture Radar Processing for the Spaceborne Sliding Spotlight Mode

Gaofen-3 (GF-3) is China’ first C-band multi-polarization synthetic aperture radar (SAR) satellite, which also provides the sliding spotlight mode for the first time. Sliding-spotlight mode is a novel mode to realize imaging with not only high resolution, but also wide swath. Several key technologies for sliding spotlight mode in spaceborne SAR with high resolution are investigated in this paper, mainly including the imaging parameters, the methods of velocity estimation and ambiguity elimination, and the imaging algorithms. Based on the chosen Convolution BackProjection (CBP) and PFA (Polar Format Algorithm) imaging algorithms, a fast implementation method of CBP and a modified PFA method suitable for sliding spotlight mode are proposed, and the processing flows are derived in detail. Finally, the algorithms are validated by simulations and measured data.
Visualizing and Distances Using GO

The basic characteristics of the GO (The Gene Ontology Consortium, 2000) data are described in ? and the interested reader is referred there for more details. In this paper we assume that readers are familiar with the basic DAG structure of GO and with the mappings of genes to GO terms that are provide by GOA (Camon et al., 2004). We examine some of the different visualization problems and data analytic problems that can be addressed using these data. To make some of the concepts concrete and to provide extensive, but related examples we will make use of a microarray data set (Chiaretti et al., 2004). We begin with brief descriptions and reminders of some of the important concepts, as well as of our example data. Once that has been done we will then consider several different bioinformatic tasks that are of interest and show how these tasks can be carried out using software from the Bioconductor Project. The results reported in this document are based on version 3.2. 3 of the hgu95av2.db data package and on 3.7. 0 of the GO.db package. If you have different versions your results will probably be different.
Lifetime attributable risk of radiation-induced secondary cancer from proton beam therapy compared with that of intensity-modulated X-ray therapy in randomly sampled pediatric cancer patients

Abstract To investigate the amount that radiation-induced secondary cancer would be reduced by using proton beam therapy (PBT) in place of intensity-modulated X-ray therapy (IMXT) in pediatric patients, we analyzed lifetime attributable risk (LAR) as an in silico surrogate marker of the secondary cancer after these treatments. From 242 pediatric patients with cancers who were treated with PBT, 26 patients were selected by random sampling after stratification into four categories: (i) brain, head and neck, (ii) thoracic, (iii) abdominal, and (iv) whole craniospinal (WCNS) irradiation. IMXT was replanned using the same computed tomography and region of interest. Using the dose–volume histograms (DVHs) of PBT and IMXT, the LARs of Schneider et al. were calculated for the same patient. All the published dose–response models were tested for the organs at risk. Calculation of the LARs of PBT and IMXT based on the DVHs was feasible for all patients. The means ± standard deviations of the cumulative LAR difference between PBT and IMXT for the four categories were (i) 1.02 ± 0.52% (n = 7, P = 0.0021), (ii) 23.3 ± 17.2% (n = 8, P = 0.0065), (iii) 16.6 ± 19.9% (n = 8, P = 0.0497) and (iv) 50.0 ± 21.1% (n = 3, P = 0.0274), respectively (one tailed t-test). The numbers needed to treat (NNT) were (i) 98.0, (ii) 4.3, (iii) 6.0 and (iv) 2.0 for WCNS, respectively. In pediatric patients who had undergone PBT, the LAR of PBT was significantly lower than the LAR of IMXT estimated by in silico modeling. Although a validation study is required, it is suggested that the LAR would be useful as an in silico surrogate marker of secondary cancer induced by different radiotherapy techniques.
The perspectives of pre-frail and frail older people on being advised about exercise: a qualitative study

Background Exercise is considered to be the most effective strategy to treat, prevent and delay frailty, a prevalent geriatric syndrome observed in clinical practice. Encouraging frail older people to take up exercise is crucial in the management of this condition. The study aimed to explore pre-frail and frail older peoples' perspectives in relation to being advised about exercise and their perceptions of the general practitioners' (GPs) role in promoting exercise for older people. Methods Semi-structured interviews were conducted with 12 community-dwelling older (median age 83 years) participants screened pre-frail or frail using the FRAIL Screen. Their attitudes towards exercise, the advice received, their access to relevant information and their perceptions of the GP's role in promoting exercise were explored. Thematic analysis was conducted to analyse data. Results The majority of participants had a positive attitude towards exercise, and many participants indicated a preference for being advised firstly by their GPs and then other healthcare professionals. Participants living in the community reported difficulties in accessing information on exercise and indicated that local governments and GP practices should promote exercise for older people more actively. Participants living in retirement villages, however, reported having access to relevant information and being encouraged to participate in exercise. Conclusion This research identified a gap in current practice, demonstrating that GPs, healthcare providers and local governments should promote exercise for older people more actively. Convincing health professionals to encourage regular exercise among their older patients would provide an opportunity to avoid and manage frailty in this population.
A machine learning method to determine intrinsic dimension of time series data

The estimation of Intrinsic Dimension (ID) of data is particularly crucial in the unsupervised learning of nonlinear time series, as it essentially represents the minimum number of parameters to describe the data. The aim of this paper is to give both a new theoretical contribution and a machine learning algorithm that can be used for the ID estimation of time series. Several experimental results validate the proposed approach.
Research for Building High Performance Communication Service Based on Netty Protocol in Smart Health

With popularity of smart devices, people can more easily access to medical data from the underlying medical equipment and sent to the remote monitoring system or professional medical staff in smart health. However, with the continuous expansion of smart health data, the public transport protocol can't meet the requirements of special medical services, such as http protocol have a complex structure. Moreover, traditional server applications face great challenges of high concurrency and high throughput. To address these issues, this paper achieve rapid transmission of medical data services based on the Netty private protocol stack research, which combined with the network protocol architecture of the chain of responsibility. Each layer has a processing interface, different operations and avoid coupling the sender of a request to its receiver can be perform by giving more than one object a chance to handle the request. Tests show that a single server supports 45000 Medical Device Manager, which accesses with a message delivery rate of 100% and a message delay of less than 5 seconds.
Lamb wave-based quantitative identification of delamination in composite laminates

Publisher Summary With such features as comparatively high strength-to-weight and stiffness-to-weight ratios, excellent capability of resisting corrosion and tailorable mechanical properties, the use of fibre-reinforced composite structures is increasing exponentially among various communities, offering significant weight saving and immense performance enhancement. However, composite structures are highly vulnerable to structural damage, in particular the delamination that can be introduced during manufacturing, tooling, processing or service. The occurrence of delamination is a great threat to the functional operation of composite structures, potentially leading to catastrophic failure of the whole structure if it accumulates above a critical extent. With safety regarded as the paramount factor for engineered structures, it is of vital importance to identify delamination in composite structures at an early stage so as to prevent any potential failure. This has motivated the rapid development of Non-Destructive Evaluation [“NDE―] techniques. Lamb waves, guided elastic waves in plate-like structures, have been examined as a means of establishing novel NDE tools, with laudable potential to cost-effectively identify delamination in composite structures.
Tracking a CAD-ALK gene rearrangement in urine and blood of a colorectal cancer patient treated with an ALK inhibitor

Background Monitoring response and resistance to kinase inhibitors is essential to precision cancer medicine, and is usually investigated by molecular profiling of a tissue biopsy obtained at progression. However, tumor heterogeneity and tissue sampling bias limit the effectiveness of this strategy. In addition, tissue biopsies are not always feasible and are associated with risks due to the invasiveness of the procedure. To overcome these limitations, blood-based liquid biopsy analysis has proven effective to non-invasively follow tumor clonal evolution. Patients and methods We exploited urine cell-free, trans-renal DNA (tr-DNA) and matched plasma circulating tumor DNA (ctDNA) to monitor a metastatic colorectal cancer patient carrying a CAD-ALK translocation during treatment with an ALK inhibitor. Results Using a custom next generation sequencing panel we identified the genomic CAD-ALK rearrangement and a TP53 mutation in plasma ctDNA. Sensitive assays were developed to detect both alterations in urine tr-DNA. The dynamics of the CAD-ALK rearrangement in plasma and urine were concordant and paralleled the patient's clinical course. Detection of the CAD-ALK gene fusion in urine tr-DNA anticipated radiological confirmation of disease progression. Analysis of plasma ctDNA identified ALK kinase mutations that emerged during treatment with the ALK inhibitor entrectinib. Conclusion We find that urine-based genetic testing allows tracing of tumor-specific oncogenic rearrangements. This strategy could be effectively applied to non-invasively monitor tumor evolution during therapy. The same approach could be exploited to monitor minimal residual disease after surgery with curative intent in patients whose tumors carry gene fusions. The latter could be implemented without the need of patient hospitalization since urine tr-DNA can be self-collected, is stable over time and can be shipped at specified time-points to central labs for testing.
Immune-Enhancing Formulas for Patients With Cancer Undergoing Esophagectomy: Systematic Review Protocol

Background Adult patients with an esophageal cancer can potentially be compromised with postoperative leaks or fistulae if patients’ nutritional status is in a vulnerable stage. Currently in Australia, there is a growing need for clinicians to know whether use of immune-enhancing formulas (IEFs) containing Arg, omega-3, and RNA are a cost-effective approach compared with isonitrogenous-isocaloric formulas to reduce postoperative infectious complications in esophagectomy patients. Since IEFs may carry higher costs, this has led to inconsistencies in practice among clinicians and hospitals. Objective Our aim is to compile and present the most up-to-date nutrition evidence available regarding the provision of IEFs containing Arg, omega-3, and RNA to help clinicians develop an evidence-based nutrition care plan; identify available evidence of whether an esophagectomy patient should receive IEF; determine the cost-effectiveness and safety of such nutrition; and determine appropriate administration quantity and timing (pre-, peri-, or postesophagectomy). Methods This review will include RCTs involving the use of IEFs enriched with Arg, omega-3 polyunsaturated fatty acids, and RNA in the pre-, peri-, or postoperative period (for at least 5-7 days) given orally or via enteral feeding tube, in adult cancer patients undergoing esophageal resection. Lower gastrointestinal, gastric, or head cancer surgery with parenteral nutrition or non-IEF or use of isolated immunonutrient (Arg vs omega-3 vs RNA) will be excluded. Primary outcome comprises postoperative infectious complications. Secondary outcomes (pre/postoperatively) consist of cost-effectiveness, length of stay, survival/mortality, quality of life, nutritional status, percentage of weight loss, and biochemical changes. The risk of bias will be independently assessed by the reviewers, using a domain-based evaluation tool. Blinding will be assessed for subjective and objective outcome measures. Publication bias will be visually assessed by funnel plots. A meta-analysis will be generated by the Review Manager 5.3 software and represented in forest plots. Results The first results are expected in 2018. Outlining the protocol will ensure transparency for the completed review. Conclusions This protocol for a systematic review and meta-analysis will enable a comprehensive appraisal of the literature to help determine whether overall institutional savings are associated with this approach. Findings will form a knowledge base relevant to stakeholders across the health system and researchers who are involved in decision making on evidence-based nutrition care plan pathways for patients undergoing esophagectomy, as well as the use of IEF, timing, and administration quantity. Trial Registration PROSPERO Registration Number: CRD42017056908; http://www.crd. york.ac. uk/PROSPERO/ display_record. asp? ID=CRD42017056908 (Archived by WebCite at http://www.webcitation.org/6rLyeqaD6)
Predictors of Online Cancer Prevention Information Seeking Among Patients and Caregivers Across the Digital Divide: A Cross-Sectional, Correlational Study

Background The digital divide is a recognized public health problem caused by social determinants that exacerbate health disparities. Despite the “tectonic shift” in how most of the public obtains cancer information, underserved communities are at increased risk of being digitally marginalized. However, research that examines factors underlying eHealth information seeking in diverse health contexts is lacking. Objective The aim of this paper is to explore preferences and use of eHealth cancer prevention information (CPI) among patients and caregivers attending a minority-serving oncology clinic using the comprehensive model of information seeking as a theoretical framework. Specifically, the study examined the role of social determinants and prevention orientation in differences in preference and use of the Internet for CPI seeking among this diverse sample. Methods Survey methodology was used to identify social determinants and behavioral factors, including prevention orientation as correlates and predictors of respondents’ (n=252) preferences and use of eHealth for CPI seeking. Results Less than half (112/252, 44.4%) of respondents said that if faced with the need to seek CPI, they would seek this information online. In the final logistic regression model, education, ethnicity, age, and prevention orientation made significant contributions to the model (P<.05). Specifically, for each year increase in age, participants were 3% less likely to use the Internet for CPI seeking (P=.011). Compared to college graduates, respondents who did not complete high school were 11.75 times less likely to cite the Internet as a CPI carrier (P<.001) and those with a high school education were 3 times (2.99, P=.015) less likely. In addition, the odds that a Spanish speaker would cite the Internet as a CPI carrier were one-fifth (22%) of non-Hispanic whites (P=.032) and about one-quarter (26%) of English-speaking Latinos (P=.036). Finally, with each one point increase on the prevention orientation scale, respondents were 1.83 times less likely to cite online CPI seeking (P=.05). Conclusions Social determinants to health have profound influence on eHealth CPI seeking. Providers and policy makers should focus on meeting patients and family members’ CPI needs following diagnosis and increase eHealth accessibility and availability of evidence-based CPI to diverse populations. Future research is needed to unravel further differences in eHealth CPI seeking, including those among Native Americans that emerged as an additional digitally underserved racial/ethnic group. Finally, additional factors underlying these differences should be explored to better tailor CPI eHealth information to diverse communities’ information needs.