Miracle-dz/UniFAR-FTUs huggingface dataset:
Generating behavior-based malware detection models with genetic programming

Malware remains a major IT security threat and current detection approaches struggle to cope with a professionalized malware development industry. We propose the use of genetic programming to generate effective and robust malware detection models which we call FrankenMods. These are sets of graph metrics that capture characteristic malware behavior. Evolution of FrankenMods with good detection capabilities yields continuously improved detection effectiveness. FrankenMods are operationalized by evaluating them on quantitative data flow graphs that model malware behavior as data flows between system resources caused by issued system calls. We show that FrankenMods are substantially more robust and effective than a state-of-the-art graph metric-based detection approach.
Deploying New Hash Functions

The strength of hash functions such as MD5 and SHA-1 has been called into question as a result of recent discoveries. Regardless of whether or not it is necessary to move away from those now, it is clear that it will be necessary to do so in the not-too-distant future. This poses a number of challenges, especially for certificate-based protocols . We analyze a number of protocols, including S/MIME and TLS. All require protocol or implementation changes. We explain the necessary changes, show how the conversion can be done, and list what measures should be taken immediately.
An investigation of how parents and non-parents attend to infant and child faces

Detecting infant facial cues is a necessary precursor for effective parenting responses. The question arises whether infant faces elicit preferential allocation of attention in order to facilitate such detection. This thesis employed variations of an existing behavioural attentional paradigm (Hodsoll, Viding, & Lavie, 2011) in first-time parents and non-parents. Individual differences in attentional engagement to infant faces were investigated in relation to: parental status; sex; current symptoms of depression; parenting stress; and childhood experience of maltreatment. Mothers and fathers, and women without children, were found to show greater attentional engagement with infant faces compared to adult, adolescent, and pre- adolescent faces (Chapters 2-4). Parents as compared to non-parents showed the greatest level of attentional engagement with infant faces, and mothers and fathers showed a similar pattern of response (Chapter 4). However, pre-adolescent child faces receive enhanced attentional engagement as compared to older faces, but only when displaying negative affect (Chapters 3 and 4). Emotion was found to play an important role, with parents and non-parents showing enhanced attentional engagement with infant faces when they displayed emotional expressions (Chapters 2-4). Current parenting stress and experience of childhood maltreatment were found to be associated with individual differences in attention to infant compared to adult faces; by contrast, current symptoms of depression were not associated with performance on the attention task (Chapters 1 and 5). These findings suggest that infant faces are inherently salient stimuli, especially for parents of infants. Increased attention to infant faces may reflect part of a wider set of adaptive behavioural changes associated with becoming a parent. However, these changes appear to be modulated by early or current adverse life experience, which may affect normative attention processes involved in detecting infant facial cues, with possible implications for parenting behaviour.
Neural mechanisms underlying the clasp-knife reflex in the cat. II. Stretch-sensitive muscular-free nerve endings.

1. The goal of this study was to determine the contribution of muscular free nerve endings to the clasp-knife reflex by comparing their response properties and reflex actions to the clasp-knife reflex. 2. The responses of single muscle afferents were examined in anesthetized cats using stretch and isometric contraction of ankle extensor muscles identical to those that evoked clasp-knife inhibition in decerebrated and dorsal spinal-hemisectioned cats. 3. Fifty-three stretch-sensitive mechanoreceptor afferents were identified as free nerve ending afferents based on their conduction velocities, location within the muscle, uniformity of response, and dissimilarity to other muscle proprioceptors. The afferent conduction velocities were in both the group III (56%) and group II (44%) range, including five fast-conducting group II afferents (greater than 55 m/s). 4. The stretch response of stretch-sensitive, free nerve endings (SSFNEs) showed several characteristic features: 1) afferents were excited only by large stretches that produced significant passive force; 2) afferent activity began after a brief delay and exhibited segmentation of discharge during ramp stretch, a maximum at the end of ramp stretch, and rapid and complete decay during static stretch, and 3) afferent response adapted to repeated stretches. These properties match those of clasp-knife inhibition described in the companion paper, except that the SSFNE segmentation and maximum were more pronounced and their decay during maintained stretch was more rapid. 5. Isometric contraction produced by electrical stimulation of the muscle nerve, which induced force-evoked inhibition in decerebrated and dorsal hemisectioned cats, also consistently excited SSFNEs. Stretch evoked greater excitation than contraction, indicating that both length and force contribute to SSFNE activity. 6. Stimulation of free nerve endings by squeezing the achilles tendon in cats exhibiting the clasp-knife reflex evoked powerful, homonymous inhibition and a flexion-withdrawal pattern of reflex action--that is, inhibition of extensor and excitation of flexor muscles throughout the hindlimb, which parallels the spatial divergence of the clasp-knife reflex. 7. Intrathecal application of capsaicin, which preferentially blocks the reflex actions of small afferent fibers, blocked clasp-knife inhibition in decerebrated, dorsal hemisectioned cats. 8. The similarities between the reflex actions and response properties of SSFNEs and the properties of the clasp-knife reflex suggest that SSFNEs mediate clasp-knife inhibition. (ABSTRACT TRUNCATED AT 400 WORDS)
A method for soluble overexpression of the α7 nicotinic acetylcholine receptor extracellular domain

We describe the construction of a soluble protein carrying the N-terminal extracellular domain (ECD) of the α7 subunit of the nicotinic acetylcholine receptor. The approach was to fuse the α7 ECD at the C and N termini of several monomeric and pentameric soluble carrier proteins and to investigate the soluble expression of the product in Escherichia coli. An initial screening of six carrier proteins resulted in the selection of a fusion protein comprising, from the N to the C terminus, the maltose binding protein, a 17-aa linker containing an enterokinase binding site, and the α7 ECD. This protein is soluble upon expression in bacteria and is purified by affinity chromatography. It binds the competitive nicotinic antagonist α-bungarotoxin with 2.5 μM affinity and displays a CD spectrum corresponding to a folded protein. The method might be suitable to produce large quantities of protein for crystallization and immunochemical experiments.
A Hybrid Integrated Light Source on a Silicon Platform Using a Trident Spot-Size Converter

This paper reports a hybrid integrated light source fabricated on a Si platform using a spot-size converter (SSC) with a trident Si waveguide. Low-loss coupling for 1.55 μm and 1.3 μm wavelengths was achieved with merely the simple planar form of a Si waveguide with no use of complicated structures such as vertical tapers or an extra dielectric core overlaid on the waveguide. The coupling loss tolerance up to a 1 dB loss increase was larger than the accuracy of our passive alignment technology. The coupling efficiency was quite robust against manufacturing variations in the waveguide width compared with that of a conventional SSC with an inverse taper waveguide. A multi-channel light source with highly uniform output power and a high-temperature light source were fabricated with a 1.55 μm quantum well laser and a 1.3 μm quantum dot laser, respectively. The integration scheme we report can be used to fabricate light sources for high-density, multi-channel Si optical interposers.
CPRecycle: Recycling Cyclic Prefix for Versatile Interference Mitigation in OFDM based Wireless Systems

OFDM is currently the most popular PHY-layer carrier modulation technique, used in the latest generations of cellular, Wi-Fi and TV standards. OFDM systems use cycle prefix to mitigate inter-symbol interference. However, most of the existing systems over-provision the size of the cycle prefix considering the worst case scenarios which rarely occur. We propose a novel OFDM PHY receiver design, called CPRecycle , that exploits the redundant cycle prefix to reduce the effects of interference from neighboring nodes. CPRecycle is based on the key observation that the starting position of the FFT window within the cyclic prefix at the OFDM receiver does not affect the received signal but can substantially reduce interference from concurrent transmissions. We further develop an algorithm that is able to find the optimal starting position of the FFT window for each subcarrier using a Gaussian kernel density function and a fixed sphere maximum likelihood detector. Through implementation and extensive evaluations using USRP and off- the-shelf IEEE 802.11g transmitters/interferers, we show the effectiveness of CPRecycle in significantly mitigating interference. CPRecycle only requires local modifications at the receiver and does not require changes in standards, making it incrementally deployable.
Effects of breathing parameters on sidestream cigarette smoke deposition in a hollow tracheobronchial model.

The effects of variations in cyclic breathing parameters (i.e., tidal volume and breath frequency) have been the subject of few studies devoted to the deposition of submicrometer aerosols in the human respiratory tract. Therefore, a series of experiments was performed to investigate whether the deposition efficiency (DE) of sidestream cigarette smoke is altered by varying tidal volume and breath frequency in a child-size hollow tracheobronchial (TB) model while maintaining a fixed minute ventilation rate of 5 L/min. Under cyclic flow conditions with tidal volumes of 100 mL (50 breaths/min), 250 mL (20 breaths/min), 500 mL (10 breaths/min) and 750 mL (6.7 breaths/min), sidestream cigarette smoke was passed through replicas of an idealized hollow TB model. The smoke deposits were extracted and then quantitated spectrophotometrically. The experiments revealed a significant difference in DE between the 100-mL tidal volume (DE = 6.0%) and the 750-mL tidal volume (DE = 11.1%). Under equivalent steady flow conditions, the mean DE was 21.5%. A trend was evident in the data--DE increased as tidal volume increased (and breathing frequency decreased)--suggesting that the influence of diffusion and secondary flows on DE becomes greater as the air residence time increases and the degree of air turbulence decreases. The results provide evidence of the importance of breathing parameters when attempting to model in vivo deposition of environmental tobacco smoke and other similar-size respirable aerosols.
A secret story about the Yagi antenna

A hitherto unpublicized story about a note thrown away by a British soldier named Newmann in Singapore during World War II, which revealed to the Japanese that the Yagi-Uda antenna was being used by the British in radar systems, is related. The invention of the Yagi-Uda antenna and its practical use in Europe are briefly discussed, and the role of radar and the Yagi-Uda antenna in Japan's defeat in the Pacific discussed. The history of Newmann's note is recounted in detail, and portions of the note itself are reproduced. <<ETX>>
The Relationship of On-Call Work with Fatigue, Work-Home Interference, and Perceived Performance Difficulties

Objectives. This study examined the relationship between on-call duty exposure (active and total on-call hours a month, number of calls per duty) and employees' experiences of being on-call (stress due to unpredictability, ability to relax during inactive on-call periods, restrictions during on-call duties, on-call work demands, and satisfaction with compensation for on-call duties) on the one hand and fatigue, strain-based and time-based work-home interference (WHI), and perceived on-call performance difficulties (PPD) on the other hand. Methods. Cross-sectional survey data were collected among a large heterogeneous sample of Dutch employees (N = 5437). The final sample consisted of 157 on-call workers (23–69 years, 71% males). Data were analyzed by means of hierarchical regression analyses (controlling for age and job characteristics). Results. Differences in on-call work exposure were not systematically related to fatigue, WHI, and PPD (all p's >0.50). The experience of being on-call explained a medium proportion of the variation in fatigue and strain-based WHI and a medium to large proportion of the variation in time-based WHI and PPD over and above the control variables. Conclusions. Our results suggest that it is employees' experience of being on-call, especially the experience of stress due to the unpredictability, rather than the amount of exposure, that is related to fatigue, WHI, and perceived on-call performance difficulties.
Routing with deceptive information

Routing protocols based on the link-state paradigm notoriously suffer from the problem of stale information in highly dynamic traffic scenarios, leading to an overall loss in routing efficiency. Solutions are not easy to come by, since an increase in the frequency of link state advertisements is equally dangerous: route flapping (i.e., periodic route changes that force traffic to be routed through an alternately underloaded set of paths) is one of the main drawbacks. In this paper we propose a novel, yet simple link state mechanism that may deliberately advertise false link state information with the purpose of stabilizing the routing, while keeping a high network utilization
Aggregated search interface preferences in multi-session search tasks

Aggregated search interfaces provide users with an overview of results from various sources. Two general types of display exist: tabbed, with access to each source in a separate tab, and blended, which combines multiple sources into a single result page. Multi-session search tasks, e.g., a research project, consist of multiple stages, each with its own sub-tasks. Several factors involved in multi-session search tasks have been found to influence user search behavior. We investigate whether user preference for source presentation changes during a multi-session search task. The dynamic nature of multi-session search tasks makes the design of a controlled experiment a non-trivial challenge. We adopt a methodology based on triangulation and conduct two types of observational study: a longitudinal study and a laboratory study. In the longitudinal study we follow the use of tabbed and blended displays by 25 students during a project. We find that while a tabbed display is used more than a blended display, subjects repeatedly switch between displays during the project. Use of the tabbed display is motivated by a need to zoom in on a specific source, while the blended display is used to explore available material across sources whenever the information need changes. In a laboratory study 44 students completed a multi-session search task composed of three sub-tasks, the first with a tabbed display, the second and third with blended displays. The tasks were manipulated by either providing three task about the same topic or about three different topics. We find that a stable information need over multiple sub-tasks negatively influences perceived usability of the blended displays, while we do not find an influence when the information need changes.
Building Complex Tissues: High-throughput Screening for Molecules Required in Hair Engineering Conflict of Interest

A fully functional model of hair reconstitution remains elusive because of the complexity of cellular organization and the number of molecular interactions that must be approximated. In this issue, Havlickova et al. (2009) report a significant contribution to hair engineering with their human folliculoid microsphere assay. When attempting to convert stem cells to products useful in regenerative medicine , the cellular organization and molecular interactions required for function reside on a continuum of morphological complexity and pose unique barriers to research. Bone marrow stem cells have already been in clinical use partially because blood cells do not require spatial organization and because differentiated blood cells can function upon release into the bloodstream. Tissues that release secreted molecules, such as insulin and dopamine to prevent diabetes and Parkinson disease, represent a second level of complexity. The topological organization of cells secreting these substances is not critical, but rigorous regulation of the synthesis and secretion of these biologically powerful molecules is absolutely necessary. Tissues constructed such that the cell morphology, structure, and organization are critical to their function represent a higher level of complexity. These include the skin, cartilage, and bone. Last, in the most complex tissue/organ category, not only is proper architecture required, but integration at a functional level is also necessary, as in cardiac systems and neural circuits. Hair belongs to the third order of difficulty in organ regeneration because a complex three-dimensional organization is required to promote fully functional tissue appendages. In normal skin regeneration, different cell types derived from two germ layers, the epi-dermis and dermis, give rise to multiple cell types, which then require additional tissue interaction and anatomic orientation to function. Assays that assist in our understanding of the molecules integral to hair regeneration must allow the use of germ cell populations from both the epidermis and the dermis and, given the number of potential interactions, a high throughput system would facilitate a more rapid understanding of their molecular regulation. Here we discuss the status of research involving the building of complex tissues with proper architecture. Two major bottlenecks must be addressed before we can successfully use stem cells to grow hair in animal models and, ultimately , in humans. The first bottleneck is to understand the molecular signaling that regulates the specification of cellular fate. In hair this is especially complicated because we must address cell types derived from two germ layers. The other challenge …
The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: Implications in neurological disorders

In the brain, the histidine triad nucleotide-binding protein 1 (HINT1) and sigma 1 receptors (σ1Rs) coordinate the activity of certain G-protein coupled receptors (GPCRs) with that of glutamate N-methyl-D-aspartate receptors (NMDARs). To determine the role of HINT1-σ1R in the plasticity of GPCR-NMDAR interactions, substances acting at MOR, cannabinoid CB1 receptor, NMDAR and σ1R were injected into mice, and their effects were evaluated through in vivo, ex vivo, and in vitro assays. It was observed that HINT1 protein binds to GPCRs and NMDAR NR1 subunits in a calcium-independent manner, whereas σ1R binding to these proteins increases in the presence of calcium. In this scenario, σ1R agonists keep HINT1 at the GPCR and stimulate GPCR-NMDAR interaction, whereas σ1R antagonists transfer HINT1 to NR1 subunits and disengage both receptors. This regulation is lost in σ1R−/− mice, where HINT1 proteins mostly associate with NMDARs, and GPCRs are physically and functionally disconnected from NMDARs. In HINT1−/− mice, ischemia produces low NMDAR-mediated brain damage, suggesting that several different GPCRs enhance glutamate excitotoxicity via HINT1-σ1R. Thus, several GPCRs associate with NMDARs by a dynamic process under the physiological control of HINT1 proteins and σ1Rs. The NMDAR-HINT1-σ1R complex deserves attention because it offers new therapeutic opportunities.
NSAID-Induced Enteropathy in Rheumatoid Arthritis Patients with Chronic Occult Gastrointestinal Bleeding: A Prospective Capsule Endoscopy Study

Background. The purpose of study was to evaluate the diagnostic yield of capsule endoscopy for NSAID-induced enteropathy and clinical, laboratory, and endoscopic characteristics of disease in patients with rheumatoid arthritis. Methods. 37 rheumatoid arthritis patients (30 women; mean age 55) treated with NSAIDs (>1 month), presented with anaemia and/or positive faecal occult blood testing, entered the study and underwent capsule endoscopy (EndoCapsule; Olympus), laboratory tests, and filled in questionnaires. Results. The prevalence of NSAID-induced enteropathy diagnosed by capsule endoscopy was 68% (25/37), classified as mild (red spots or erosions) in 18 (49%), moderate (10–20 erosions) in 4 (11%), and severe enteropathy (>20 erosions or ulcers) in 3 (8%) patients. We did not find statistically significant relationship between the enteropathy and gender, age, haemoglobin, leukocytes, albumin and CRP, or dyspepsia. The difference between subgroups of NSAIDs according to the COX specificity was not statistically significant. Conclusions. Capsule endoscopy is a highly accurate noninvasive method for evaluation of NSAID-induced enteropathy. It was revealed in a substantial section of the patients with rheumatoid arthritis and occult gastrointestinal bleeding, mostly classified as mild damage. No simple clinical or laboratory markers of the presence or severity of NSAID-induced enteropathy were recognised. This trial is registered with DRKS00004940.
Schizophrenia and Attention Deficit Disorder

Abstract: Attentional dysfunction can be found in nearly every form of psychopathology, not just in attention deficit disorder (ADD). Being able to distinguish ADD from other psychiatric conditions is crucial for clinicians working with adolescents and young adults, particularly in the case of psychoses where making the correct diagnosis and beginning treatment promptly is extremely important. In this paper we review the literature on the attentional dysfunction found in schizophrenia and compare it to that found in ADD in an effort to increase our knowledge of etiology and underlying mechanisms. Investigators studying ADD may learn from the study of schizophrenia by realizing that ADD is also a complex disorder of attention that occurs across the developmental spectrum and is characterized by various predispositional, environmental, and maturational factors.
Time Equations for Lazy Functional (Logic) Languages

There are very few approaches to measure the execution costs of lazy functional (logic) programs. The use of a lazy execution mechanism implies that the complexity of an evaluation depends on its context, i.e., the evaluation of the same expression may have different costs depending on the degree of evaluation required by the different contexts where it appears. In this paper, we present a novel approach to complexity analysis of functional (logic) programs. We focus on the construction of equations which compute the time-complexity of expressions. In contrast to previous approaches, it is simple, precise—i.e., it computes exact costs rather than upper/lower bounds—, and fully automatic.