Miracle-dz/UniFAR-FTUs huggingface dataset:
Milk folate but not milk iron concentrations may be inadequate for some infants in a rural farming community in San Mateo, Capulhuac, Mexico.

BACKGROUND We were interested in identifying possible nutritional reasons for growth faltering among breastfed infants in the rural farming community of San Mateo, Capulhuac, Mexico (2800 m above sea level). OBJECTIVE We examined the prevalence of inadequate iron and folate status among lactating Otomi women and determined to what extent their iron and folate nutriture influenced the milk concentrations of these nutrients. DESIGN Lactating women (n = 71) provided blood and milk samples and dietary information at a mean (+/- SD) of 22 +/- 13 d postpartum. Blood indexes included hemoglobin, hematocrit, serum iron, total-iron-binding capacity, ferritin, transferrin receptor, mean cell volume, plasma folate, and erythrocyte folate. RESULTS Approximately 62% and 58% of the women had nutritional anemia defined as a hemoglobin concentration </= 133 g/L and a hematocrit value of 41.0%, respectively. With the use of a 3-index iron assessment model, 2 of the 66 women whose iron status was assessed (3%) had iron-deficient erythropoiesis, and 24 (36%) had iron deficiency anemia. Among the 67 women whose folate status was assessed, 29 (43%) had a low plasma folate concentration, and 13 (19%) had a low blood folate concentration in conjunction with a low hemoglobin concentration. Milk iron content was unrelated to maternal iron status, and the milk provided more than adequate amounts of iron to the infants. In contrast, the infants' predicted folate intake was approximately 45 micro g/d, or 70% of the current recommended intake. CONCLUSION Milk folate concentrations in Otomi women are low and may not support optimal folate status in all breastfed infants.
Molecular modeling, dynamics simulations, and binding efficiency of berberine derivatives: A new group of RAF inhibitors for cancer treatment

RAF kinases are a family of enzymes in the MAP kinase pathway that contribute to the development of different types of cancer. BRAF is the most important member of RAF kinases. BRAF mutations have been detected in 7% of all cancers and 66% of melanomas; as such, the FDA has approved a few BRAF inhibitor drugs to date. However, BRAF can activate CRAF leading to resistance to BRAF inhibitors. Berberine (BBR) is an alkaloid that is widely distributed in different plant species. Several studies have been carried out on the anti-cancer effects of BBR but direct targets of BBR are unknown. In this study, interactions of BBR derivatives against BRAF and CRAF kinases were modeled and predicted using an in silico-based approach. To analyze and identify the residues important in BRAF docking, we modeled interactions of ATP, the universal substrate of BRAF, and found that Lys483 and Asp594 are the most important residues involved in both ATP and BBR binding [(The average score = -11.5 kcal/mol (ATP); Range of scores = -7.78 to -9.55 kcal/mol (BBR)]. In addition to these polar residues, Trp530 and Phe583 are also applicable to the molecular docking of BRAF. We also observed that Asp593 was excluded from the enzyme cavity, while Phe594 was included inside the cavity, making the enzyme inactive. Finally, three alternatives for BBR were identified with dual RAF inhibition effects [The best scores against BRAF = -11.62 kcal/mol (BBR-7), -10.64 kcal/mol (BBR-9), and -11.01 kcal/mol (BBR-10); the best scores against CRAF = -9.68 kcal/mol (BBR-7), -9.60 kcal/mol (BBR-9), and -9.20 kcal/mol (BBR-10)]. Direct effects of BBR derivatives against BRAF and CRAF kinases had not yet been reported previously, and, thus, for the first time, we report three cycloprotoberberines as lead compounds against RAF kinases.
Predators catalyze an increase in chloroviruses by foraging on the symbiotic hosts of zoochlorellae

Significance Reproduction and growth of viruses depend on successful encounters with appropriate hosts. However, some hosts are difficult to encounter. In particular, chloroviruses cannot reach their target zoochlorellae hosts, because zoochlorellae are endosymbionts, living inside the cell of a protist that protects the zoochlorellae from the chlorovirus. The protist host is subject to predation, and we show that copepods foraging on zoochlorellae-bearing protists can disrupt the mutualism and pass endosymbiontic zoochlorellae through their guts, exposing them to chloroviruses. In this way, predators can catalyze the virus population growth by breaking down physical barriers between viruses and their endosymbiont hosts. Virus population growth depends on contacts between viruses and their hosts. It is often unclear how sufficient contacts are made between viruses and their specific hosts to generate spikes in viral abundance. Here, we show that copepods, acting as predators, can bring aquatic viruses and their algal hosts into contact. Specifically, predation of the protist Paramecium bursaria by copepods resulted in a >100-fold increase in the number of chloroviruses in 1 d. Copepod predation can be seen as an ecological “catalyst” by increasing contacts between chloroviruses and their hosts, zoochlorellae (endosymbiotic algae that live within paramecia), thereby facilitating viral population growth. When feeding, copepods passed P. bursaria through their digestive tract only partially digested, releasing endosymbiotic algae that still supported viral reproduction and resulting in a virus population spike. A simple predator–prey model parameterized for copepods consuming protists generates cycle periods for viruses consistent with those observed in natural ponds. Food webs are replete with similar symbiotic organisms, and we suspect the predator catalyst mechanism is capable of generating blooms for other endosymbiont-targeting viruses.
Influence of tidal volume and positive end-expiratory pressure on ventilation distribution and oxygenation during one-lung ventilation

Objective: The aim of the study was to explore the feasibility of titrating tidal volume (VT) and positive end-expiratory pressure (PEEP) during one-lung ventilation (OLV) based on ventilation distribution and oxygenation. Approach: Twenty-four consecutive patients requiring intubation with a double-lumen tube and subsequent OLV for thoracic surgical procedures were examined prospectively in lateral posture. Electrical impedance tomography (EIT), blood gases, respiratory mechanics were successfully measured in 21 patients at various combinations of VT (4 ml kg−1, 6 ml kg−1, 8 ml kg−1 body weight) and PEEP (0 cm H2O, 4 cm H2O, 8 cm H2O) during OLV. Main results: Low VT and low PEEP resulted in low global respiratory system compliance (Crs). Arterial partial pressure of O2 (PaO2) decreased with falling VT. Regional Crs measured with EIT showed high values at high VT and high PEEP in all but two patients. Regional Crs in mid and most dependent regions indicated tidal recruitment/derecruitment in eight patients at 8 ml kg−1 of VT and 4 cm H2O of PEEP; in four patients at 8 ml kg−1 and 0 cm H2O; in one patient at 6 ml kg−1 and 8 cm H2O. The changes in regional Crs induced by decreasing PEEP from 8 to 4 cm H2O were much smaller than those from 4 to 0 cm H2O. Ventilation distribution was most inhomogeneous with VT of 8 ml kg−1. All measures differed significantly among various VT and PEEP steps (p < 0.05). Significance: By using EIT in combination with PaO2, it is feasible to titrate VT and PEEP at the bedside during OLV.
(+)-Catechin in human plasma after ingestion of a single serving of reconstituted red wine.

BACKGROUND Red wine consumption may decrease the risk of coronary heart disease through the actions of its constituent flavonoids. (+)-Catechin is an abundant flavonoid in red wine. OBJECTIVE The objective was to determine changes in plasma (+)-catechin concentrations after ingestion of a single, moderate serving of dealcoholized red wine reconstituted with either water (DRW) or water and alcohol (ARW). DESIGN Nine subjects (5 men, 4 women) ingested, in random order, 120 mL DRW on one day and 120 mL ARW on another day. Both the DRW and ARW contained 35 mg (121 micromol) free (+)-catechin. Blood samples were collected at 0, 0.5, 1, 2, 3, 4, and 8 h. Plasma was analyzed by gas chromatography-mass spectrometry for (+)-catechin after enzymatic release of sulfate and glucuronide conjugates. RESULTS Calcium ions were needed to effectively hydrolyze (+)-catechin conjugates in plasma containing EDTA. Neither the ARW or DRW nor sex affected the area under the curve at 8 h, the maximum concentration (c(max)), or the time it took for plasma total (+)-catechin to reach maximum concentration (t(max)). Pooled mean (+/-SEM) values for the ARW and DRW were as follows: area under the curve, 306.1 +/- 29.5 nmol*h/L; c(max), 76.7 +/- 7.5 nmol/L; and t(max), 1.44 +/- 0.13 h. The half-life of (+)-catechin in plasma was significantly less (P = 0.038) after ingestion of the ARW (3.17 h) than after ingestion of the DRW (4.08 h). CONCLUSIONS Increases in plasma total (+)-catechin concentrations were not significantly different after single moderate servings of either the ARW or DRW. Alcohol in the ARW hastened the elimination of (+)-catechin from the plasma compartment. (+)-Catechin elimination may represent excretion or conversion to methylated derivatives.
Body composition in adolescents with anorexia nervosa.

BACKGROUND Malnourished patients with anorexia nervosa have altered body composition characterized by depletion of fat and fat-free mass. OBJECTIVES The objectives of this study were to assess the body composition of adolescents with anorexia nervosa compared with that of control subjects and to investigate the relation between simple anthropometric measures and reference techniques for measuring body composition. DESIGN Twenty-three adolescent females with anorexia nervosa aged 15.46 +/- 1.34 y (x +/- SD) were studied. Body composition was measured by anthropometry, dual-energy X-ray absorptiometry (DXA) (for body fat), and prompt gamma in vivo neutron activation analysis [for total body nitrogen (TBN)]. Twenty-five female subjects provided the control DXA data. TBN measurements were compared with prediction equations based on sex, height, age, and weight. RESULTS Anorexia nervosa patients had significantly lower weight (40.2 +/- 4.6 kg), body mass index (in kg/m(2): 15.3 +/- 1.2), percentage of body fat (DXA) (13.8 +/- 5.8%), percentage of TBN predicted for age (73 +/- 10%), trunk fat (2.1 +/- 1.0 kg), leg fat (2.6 +/- 1.1 kg), and trunk-to-leg fat ratio than did control subjects (P < 0.05). In anorexia nervosa patients, significant correlations were found between triceps skinfold thickness and percentage of body fat (r = 0.83), body mass index and percentage of body fat (r = 0.46), and body weight and TBN (r = 0.84, P < 0.05). CONCLUSIONS Hospitalized adolescent females with anorexia nervosa are depleted of total body fat and protein. We identified 3 simple anthropometric measures (triceps skinfold thickness, BMI, and body weight) that can be used to assess body composition and nutritional status in malnourished adolescents with anorexia nervosa.
Prevalence and significance of low 25-hydroxyvitamin D concentrations in healthy subjects in Delhi.

BACKGROUND Despite abundant sunlight, rickets and osteomalacia are prevalent in South Asian countries. The cause of this paradox is not clear. OBJECTIVE The objective was to assess 25-hydroxyvitamin D [25(OH)D] status and its functional significance in apparently healthy subjects residing in Delhi, a city in the northern part of India. DESIGN Serum 25(OH)D, total calcium, inorganic phosphate, alkaline phosphatase, intact parathyroid hormone, and 1, 25-dihydroxyvitamin D [1,25(OH)(2)D] were measured in groups of healthy subjects who differed with respect to variables relevant to vitamin D and bone mineral metabolic status, such as direct sunlight exposure, season of measurement, skin pigmentation, dietary calcium and phytate contents, and altered physiologic states such as pregnancy and neonatal age. RESULTS All groups except one with maximum direct sunlight exposure had subnormal concentrations of 25(OH)D. The 25(OH)D-deficient groups tended to have an imbalance in bone mineral metabolic homeostasis when exposed to winter weather and low dietary calcium and high dietary phytate, with significantly low calcium and elevated intact parathyroid hormone concentrations, chemical osteomalacia, or both. Increased values of 1,25(OH)(2)D during pregnancy did not help correct the imbalance in bone mineral metabolic homeostasis. CONCLUSION Healthy subjects with low 25(OH)D concentrations are at risk of bone mineral metabolic imbalance when exposed to factors that strain bone mineral homeostasis.
Empirical assessment of transgene flow from transgenic poplar plantation 2 3

To assess the possible impact of transgenic poplar plantations on the ecosystem, we analyzed the frequency and distance of gene flow from a mature male transgenic Populus nigra carried Bacillus thuringiensis toxin gene (Bt-OE poplar) plantation, and the survival of Bt-OE poplar seeds as well. The resultant Bt-OE poplar seeds occurred at a frequency from ~0.15% at 0 m to ~0.02% at 500 m far away from the Bt-OE poplar. The Bt-OE poplar seeds weaken and even lost germinated activation within 3 weeks in the field (from 68% to 0%), compared to the 48% germination rate after 3 weeks in 4°C. The survival rate of seedlings in the field is 0% without any treatments, but increased to 1.7% under four treatments (Clean and trim, watering, weeding, and cover with plastic to keep moisture) together after seeded in the field for eight weeks. Results of this study indicate that gene flow originated from Bt-OE poplar plantation through pollen and seed could happen at a very low rate and in a limited range in natural conditions. This study provide the first-hand field data on the extent of transgene flow in poplar plantations, and offer guidance for risk assessment of transgenic poplar plantations.
The Twist Tensor Nuclear Norm for Video Completion

In this paper, we propose a new low-rank tensor model based on the circulant algebra, namely, twist tensor nuclear norm (t-TNN). The twist tensor denotes a three-way tensor representation to laterally store 2-D data slices in order. On one hand, t-TNN convexly relaxes the tensor multirank of the twist tensor in the Fourier domain, which allows an efficient computation using fast Fourier transform. On the other, t-TNN is equal to the nuclear norm of block circulant matricization of the twist tensor in the original domain, which extends the traditional matrix nuclear norm in a block circulant way. We test the t-TNN model on a video completion application that aims to fill missing values and the experiment results validate its effectiveness, especially when dealing with video recorded by a nonstationary panning camera. The block circulant matricization of the twist tensor can be transformed into a circulant block representation with nuclear norm invariance. This representation, after transformation, exploits the horizontal translation relationship between the frames in a video, and endows the t-TNN model with a more powerful ability to reconstruct panning videos than the existing state-of-the-art low-rank models.
Data-Centric Mobile Crowdsensing

Mobile crowdsensing (MCS) is a novel and appealing sensing paradigm that leverages the diverse embedded sensors of massive mobile devices to collect different kinds of data. One of the key challenges in MCS is to efficiently schedule mobile device users to perform different sensing tasks. Prior effort to this problem mainly focused on the interaction between the task-layer and the user-layer, without considering the similar data requirements of tasks and the heterogeneous sensing capabilities of users. In this work, we introduce a new data-layer between tasks and users, and propose a three-layer data-centric MCS framework, which enables different tasks to reveal their common data requirements and hence reuse the common data items. We focus on studying the joint task selection and user scheduling problem under this new framework, aiming at maximizing the social welfare. Specifically, we first analyze theoretical performance gain due to data reuse in the ideal scenario with complete information. We then consider the practical scenario with private information of both tasks and users, and propose a two-sided randomized auction mechanism, which is computationally efficient, individually rational, incentive compatible (truthful) in expectation, and close-to-optimal. We further show that the proposed randomized auction may not be budget balanced, and hence introduce a reserve price into the auction to achieve the desired budget balance at the cost of certain welfare loss. Simulation results show that with data reuse, the social welfare achieved in the proposed randomized auction can be increased from 270 up to 4,500 percent, comparing with those without data reuse.
Mitral annular calcification progression and the risk of atrial fibrillation: results from MESA

Aims To determine if progression of mitral annular calcium (MAC) detected by cardiac computed tomography (CT) predicts incident atrial fibrillation (AF). Methods and results This analysis included 5683 participants (mean age 64 ± 10 years; 52% women; 40% whites; 27% blacks; 21% Hispanics; 12% Chinese-Americans) from the Multi-Ethnic Study of Atherosclerosis. MAC was measured by cardiac CT at baseline and at a follow-up CT scan over a mean time of 2.4 ± 0.84 years. AF was ascertained by review of hospital discharge records and from Medicare claims data through 31 December 2012. Cox regression was used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between MAC progression and AF. Over a median follow-up of 8.6 years, a total of 533 (9.4%) incident AF cases were detected. In a model adjusted for age, sex, race/ethnicity, education, income, baseline MAC, systolic blood pressure, body mass index, diabetes, smoking, total cholesterol, high-density lipoprotein cholesterol, antihypertensive medications, lipid-lowering therapies, and aspirin, any MAC progression (>0/year) was associated with an increased risk for AF (HR = 1.50, 95% CI = 1.20-1.87). Multiplicative interactions were not significant between MAC progression and AF by age (<65 year vs. older), sex, or race/ethnicity (whites vs. non-whites). Conclusion Important prognostic information regarding AF risk is obtained with follow-up MAC measurement, as the risk for participants with any MAC progression was substantively greater than participants without progression. MAC progression may detect underlying left atrial abnormalities that predispose to AF.
Incorporating Bagging into Boosting

In classification learning, classifier group learning approach provides better results to predict accuracy. There are various classifiers to form a group by repeating single based learning algorithm. The members of the group make a final classification by voting. Boosting and Bagging are two popular methods from this group and decreases error rate of decision tree learning. Boosting is more accurate than Bagging, but the former is more variable than the later. In this paper, our aim is to review the state of the art on group learning techniques in the frame work of imbalanced data sets. We propose a new group learning algorithm called Incorporating Bagging in to Boosting (IB), which creates number of subgroups by incorporating Bagging into Boosting. Experimental results on natural domains show that on an average IB is more stable than either Bagging or Boosting. It is more stable than Boosting. These characteristics make IB a good choice as one of the group learning techniques.
Synthetic animated realities

This opportunity for complex spatiotemporal simulation offered by digital technologies allows a subversion of the computer’s traditional role as an image production device, through its use in my own work to create preliminary sketches as a basis for sequential pieces finished in traditional analogue forms. I am currently exploring these connections via the presentation of a variety of spatial and temporal sequential imagery in a series of exhibitions, and supporting contextual research.
Delta Ferrite and Martensite Formation in Stainless Steels From studies of 70 chill-cast stainless steel alloy types, nickel- and chromium-equivalents of 13 elements are evaluated for use in a revised Schaeffler diagram

The effects of composi­ tion on delta ferrite and martensite formation were studied in chill-cast experimental stainless steel alloys. Nickel content was varied in each of seventy different alloy types to pro­ duce structures ranging from fully stable austenite to ones containing high percentages of delta ferrite or martensite. The nickel or chromium equivalents of Mn, Mo, Si, V, W, Ti, Cb, Ta, Al, C, N, Co and Cu were evaluated by regression analyses.
A cautionary note on the effects of laboratory air contaminants on ambient ionization mass spectrometry measurements.

RATIONALE Ambient ionization mass spectrometry methods are convenient, sensitive and require little sample preparation. However, they are susceptible to species present in air surrounding the mass spectrometer. This study identifies some challenges associated with the potential impacts of indoor air contaminants on ionization and analysis involving open-air methods. METHODS Unexpected effects of volatile organic compounds (VOCs) from floor maintenance activities on ambient ionization mass spectrometry were studied using three different ambient ionization techniques. Extractive electrospray ionization (EESI), direct analysis in real time (DART) and ionization by piezoelectric direct discharge (PDD) plasma were demonstrated in this study to be affected by indoor air contaminants. Identification of contaminant vapors was verified by comparison with standards using EESI-MS/MS product ion scans. RESULTS Emissions of diethylene glycol monoethyl ether and ethylene glycol monobutyl ether are identified from floor stripping and waxing solutions using three ambient ionization mass spectrometry techniques. These unexpected indoor air contaminants are capable of more than 75% ion suppression of target analytes due to their high volatility, proton affinity and solubility compared with the target analytes. The contaminant vapors are also shown to form adducts with one of the target analytes. CONCLUSIONS The common practice in MS analysis of subtracting a background air spectrum may not be appropriate if the presence of ionizable air contaminants alters the spectrum in unexpected ways. For example, VOCs released into air from floor stripping and waxing are capable of causing ion suppression of target analytes.
Serum triglyceride responses to fatty meals: effects of meal fat content.

To determine the dose response of serum triglyceride concentrations to fat feeding, serum triglyceride responses to meals containing 40, 80, and 120 g fat (in the form of dairy cream) were measured in 12 normotriglyceridemic men. Mean postprandial lipemia (measured as the integrated area under the curve of serum triglyceride concentration plotted against time) was 251 +/- 129 mg.dL-1.8 h-1 (2.83 +/- 1.46 mmol.L-1.8 h-1) after the 40-g-fat meal, 503 +/- 233 mg.dL-18 h-1 (5.68 +/- 2.63 mmol.L-1.8 h-1) after the 80-g-fat meal, and 712 +/- 281 mg.dL-1.8 h-1 (8.04 +/- 3.17 mmol.L-1.8 h-1) after the 120-g-fat meal. These data indicate that in normotriglyceridemic men the magnitude of lipemia that follows the ingestion of a fat meal is directly proportional to the fat content of the meal. The results also suggest that the mechanism whereby triglyceride is removed from the intravascular compartment is not saturated by meals containing the amounts of fat typically consumed by men following a Western diet.