Miracle-dz/UniFAR-FTUs huggingface dataset:
Ex vivo dissection of optogenetically activated mPFC and hippocampal inputs to neurons in the basolateral amygdala: implications for fear and emotional memory

Many lines of evidence suggest that a reciprocally interconnected network comprising the amygdala, ventral hippocampus (vHC), and medial prefrontal cortex (mPFC) participates in different aspects of the acquisition and extinction of conditioned fear responses and fear behavior. This could at least in part be mediated by direct connections from mPFC or vHC to amygdala to control amygdala activity and output. However, currently the interactions between mPFC and vHC afferents and their specific targets in the amygdala are still poorly understood. Here, we use an ex-vivo optogenetic approach to dissect synaptic properties of inputs from mPFC and vHC to defined neuronal populations in the basal amygdala (BA), the area that we identify as a major target of these projections. We find that BA principal neurons (PNs) and local BA interneurons (INs) receive monosynaptic excitatory inputs from mPFC and vHC. In addition, both these inputs also recruit GABAergic feedforward inhibition in a substantial fraction of PNs, in some neurons this also comprises a slow GABAB-component. Amongst the innervated PNs we identify neurons that project back to subregions of the mPFC, indicating a loop between neurons in mPFC and BA, and a pathway from vHC to mPFC via BA. Interestingly, mPFC inputs also recruit feedforward inhibition in a fraction of INs, suggesting that these inputs can activate dis-inhibitory circuits in the BA. A general feature of both mPFC and vHC inputs to local INs is that excitatory inputs display faster rise and decay kinetics than in PNs, which would enable temporally precise signaling. However, mPFC and vHC inputs to both PNs and INs differ in their presynaptic release properties, in that vHC inputs are more depressing. In summary, our data describe novel wiring, and features of synaptic connections from mPFC and vHC to amygdala that could help to interpret functions of these interconnected brain areas at the network level.
CYCLOBUTANE DIMERS AND (6‐4)PHOTOPRODUCTS IN HUMAN CELLS ARE MENDED WITH THE SAME PATCH SIZES

The sizes of excision repair patches corresponding to excision of (6‐4) pyrimidine‐pyrimidone photoproducts and (5‐5,6–6) cyclobutane dimers have been independently determined by using bromodeoxyuridine substitution and density increases in isopycnic gradients of small DNA fragments. The two classes of photoproducts were distinguished by using (a) a xeroderma pigmentosum (XP) revertant cell line that excises (6‐4) photoproducts normally, but does not excise cyclobutane dimers from bulk DNA or from an actively transcribed sequence; (b) an XP cell line containing the denV gene of bacteriophage T4, which repairs only cyclobutane dimers by a unique glycosylase mechanism, and (c) normal cells analyzed during time intervals in which cyclobutane dimer repair is the main repair process in action. The patch sizes for the two lesions were similar under all conditions and were estimated to be approximately30–40 bases. These values are slightly larger than corresponding estimates for Escherichia coli and Saccharomyces cerevisiae but close to estimates from in vitro experiments with human cell extracts. The size of 30 bases may consequently be very close to the actual distance between cleavage sites made on either side of a photoproduct during repair.
Efficiency enhancement of wireless charging for Electric vehicles through reduction of coil misalignment

In response to the ever increasing pollution levels and depleting fossil fuels, Plug-in Electric vehicle, hybrid electric vehicle and Electric vehicle (xEVs) technologies are emerging successfully in the automotive industry. The range anxiety issue of the xEVs customers are being addressed through various charging methods. The major hurdle in adoption of xEV is deployment of charging infrastructure. The wireless charging technology is being mechanized as a preferred option in the evolving xEV market. A substantive issue in the commercialization of wireless charging is the misalignment of the vehicle and the charging pad. This paper proposes and discusses a scheme which can significantly adjust the alignment between the coils by the deliberate movement of the receiver coil in response to the magnetic field of the transmitter coil. This will reduce the additional technique required for misalignment.
Molecular imaging in vivo: an introduction.

The modern practice of medicine will soon be centred on the principles of molecular biology [1]. As a consequence technologies allowing precise, targeted and robotically delivered therapies will be needed to deliver this new practice. Significant stakeholders of this molecular approach are the pharmaceutical companies [2] and academia both of whom have committed substantial resources to targeted molecular therapies. In man the sequencing of the human genome [3, 4] has significantly facilitated this process and microarray analysis [5], bioinformatics [6] and high-throughput screening [7, 8] are providing additional insight into the molecular basis of disease. Imaging will be a key resource in delivering the practice of molecular medicine. Biomedical imaging has already played a key role in defining many cellular and biochemical mechanisms [9]. The next phase in the development of molecular imaging (MI) requires the translation of a predominantly in vitro technology to an in vivo one. This will be achieved via a synthesis of chemistry, molecular biology and imaging hardware.Ultimately the aim should be the establishment of these practices in man. MI therefore seeks to ‘‘image molecular events in vivo’’ [10] into which cell and mouse imaging are often added [11]. Although MI represents a new discipline rather than a new science its language remains unfamiliar to most imaging clinicians and scientists. Chemistry and molecular biology define the new vocabulary [12, 13]. The importance of MI should not be underestimated; the National Cancer Institute [14, 15] and National Institute of Health [16, 17] have strategically aligned themselves to its development and the teaching of the basics of MI to radiology residents is being advocated [18].
Neuropathology of ALS

ALS is an age-associated neurodegenerative disease that primarily affects the motor neuron system. Despite having been studied for over 100 years, its etiology is still a mystery, and no specific diagnostic laboratory test has been developed. The diagnosis of ALS is therefore based on clinical features and/or neuropathologic findings. The neuropathologic findings on patients with classic ALS are quite distinct, with loss and degeneration of the large anterior horn cells of the spinal cord and lower cranial motor nuclei of the brainstem. The striated muscles display denervation atrophy. Upper motor neurons, such as the Betz cells in the motor cortex, are also affected. The several symposia and workshops on the cytopathology of ALS held within the past 3 years are a reflection of the many new and important developments taking place in this area. [1] Although loss of motor neurons has been known for many years, cytoplasmic alterations of the lower motor neurons have been studied in detail only in recent years by using immunohistochemical and electron microscopic techniques. An overview of some of the novel findings associated with lower motor neuron alterations is presented here. The synapse is the most important site of neuronal function and is unique to the neuron. Despite many years of extensive studies on ALS, data regarding synaptic alterations are limited to a relatively small number of ultrastructural investigations. [2] This paucity of information is due to the inherent difficulties that affect the proper evaluation of synapses in autopsy material. Synaptophysin, a 38-kDa glycoprotein, is a constituent of the membrane of synaptic vesicles in presynaptic terminals. The evaluation of synaptophysin expression in the lumbar spinal cord of ALS patients was apparently presented for the first time by Kawanami et al. [3] at the Annual Meeting of the Canadian Association of Neuropathologists in September 1992. This …
Sexuality in women.

1With this book, our knowledge and understanding of the intricacies of sexual functioning were broadened considerably. The authors were pioneers in the study of human sexual physiology in the laboratory, and they developed a systematic way of looking at difficulties affecting various phases of the sexual response cycle. They provided a truly novel model for therapy—a specifically directed approach that produced dramatic changes in the couples they treated. Kaplan, in The New Sex Therapy,2 began the process of integrating principles of couples and individual psychodynamics with the “directed” approach of Masters and Johnson. Until relatively recently, the field involved primarily specialists in mental health. Over the last 15 years, there has been more attention from urologists, gynecologists, and endocrinologists, and research on sexuality has benefited enormously with the contributions from many disciplines. As the discipline has grown, much focus has been placed on the psychological factors that contribute to sexual difficulties, and a therapeutic approach has evolved that integrates behavioral techniques with psychodynamic understanding. Couples (or individuals) are given specific sexual “exercises” and coaching, and particular attention is paid to their reactions to the assignments. As a therapist from a traditional background of psychoanalytically oriented psychotherapy, I initially found this directed approach contrived and foreign. I was uncomfortable with giving people specific directions, had little experience in talking directly about sexual matters, and was wedded to the belief that sexual difficulties had their roots in deepseated conflicts that needed to be explored. I was therefore quite surprised to notice the resulting significant and rapid changes in couples’ sexual functioning, which bore no relation to what I might have predicted from my formal training. In the 25 years since I began working in the field of sexuality,
Diagnostic-Robust Generalized Potentials for Identifying High Leverage Points in Mediation Analysis

Due to the fact that mediation model involves several linear regression equations, there is concern not only when the data contain observations that are extreme in the response variable but also in the regressor space, namely the leverage points. The Diagnostic Robust Generalized Potentials (DRGP) procedure in multiple linear regression incorporated the Robust Mahanalobis Distance based on the minimum volume ellipsoid and uses Median Absolute Deviation as its cut-off points. In this paper, a slight modification to the DRGP is proposed and we call it ModDRGP. The ModDRGP is applied to the mediation model. The performance of our proposed ModDRGP is evaluated based on Monte Carlo simulation study. The simulation results suggest that ModDRGP has improved the accuracy of the identification of high leverage points when the percentage of high leverage points is medium or high. The method can also be used for the identification of high leverage points in multiple mediation models, as well.
Techniques For Crosstalk Avoidance In The Physical Design Of High-performance Digital Systems

Interconnect performance does not scale well into deep submicron dimensions, and the rising number of analog effects erodes the digital abstraction necessary for high levels of integration. In particular, crosstalk is an analog phenomenon of increasing relevance. To cope with the increasingly analog nature of high-performance digital system design, we propose using a constraint-driven methodology. In this paper we describe new constraint generation ideas incorporating digital sensitivity. In constraint-driven synthesis, we show that a fundamental subproblem of crosstalk channel routing, coupling-constrained graph levelization (CCL), is NP-complete, and develop a novel heuristic algorithm. To demonstrate the viability of our methodology, we introduce a gridless crosstalk-avoiding channel router as an example of a robust and truly constraint-driven synthesis tool.
Finding Money on the Table: Information, Financial Aid, and Access to College

This article considers trends in state aid and research suggesting that low-income high school students do not prepare for college because they believe it is unaffordable. Authors posit a cultural ecological framework for examining how students think about going to and paying for college, asserting that preparation for college and financial aid is multifaceted and longitudinal.
CUTANEOUS WATER LOSS AND LIPIDS OF THE STRATUM CORNEUM IN DUSKY ANTBIRDS , A LOWLAND TROPICAL BIRD

The stratum corneum, the outer layer of the epidermis, consists of flattened cells embedded in a matrix of lipids, primarily cholesterol, free fatty acids, ceramides, and cerebrosides. The stratum corneum forms a barrier to water vapor diffusion through the skin. In birds, the skin limits excessive water loss at thermoneutral temperatures, but also serves as a vehicle for thermoregulation during episodes of heat stress. We measured total evaporative water loss, cutaneous water loss, and lipids in the stratum corneum in Dusky Antbirds (Cercomacra tyrannina), the first such measurements ever made for birds living in tropical rain forests. We predicted that these birds would have high rates of cutaneous water loss because of their need to thermoregulate rather than to conserve water. We found that Dusky Antbirds lose twice as much water through their skin as birds from temperate environments. We also hypothesized that the proportion of cerebrosides in the stratum corneum would increase relative to that of ceramides if Dusky Antbirds use their skin as a thermoregulatory organ. However, we found that Dusky Antbirds did not show different proportions of ceramides and cerebrosides in the stratum corneum than other species of birds. We also found that Dusky Antbirds had low amounts of free fatty acids in their stratum corneum. Overall, our data support the idea that the interactions of the lipids in the stratum corneum may play an important role in determining rates of water vapor diffusion through the skin.
The Nature of Exemplary Doctoral Advisors' Expectations and the Ways They May Influence Doctoral Persistence

The high attrition rate from doctoral programs has been called a “hidden crisis” in graduate education (Lovitts & Nelson, 2000). Previous research has identified a constellation of factors that may contribute to doctoral attrition. However, the literature suggests that one of the most powerful influences on doctoral persistence is the relationship doctoral students develop with their advisors (Berg & Ferber, 1983; Ferrer de Valero, 2001; Girves & Wemmerus, 1988). Although there is a growing body of literature that has explored the advisor-advisee relationship with respect to persistence, little attention has been given to the examination of the expectations that advisors have of their advisees and how these expectations might impact degree completion. Therefore, this exploratory qualitative study examined the expectations that 25 exemplary advisors have of their doctoral advisees. Findings revealed 5 specific expectations advisors hold that, if met, could lead to improved doctoral student retention.
Martingale proofs of many-server heavy-traffic limits for Markovian queues ∗

This is an expository review paper illustrating the "martin- gale method" for proving many-server heavy-traffic stochastic-process lim- its for queueing models, supporting diffusion-process approximations. Care- ful treatment is given to an elementary model - the classical infinite-server model M/M/1, but models with finitely many servers and customer aban- donment are also treated. The Markovian stochastic process representing the number of customers in the system is constructed in terms of rate- 1 Poisson processes in two ways: (i) through random time changes and (ii) through random thinnings. Associated martingale representations are obtained for these constructions by applying, respectively: (i) optional stop- ping theorems where the random time changes are the stopping times and (ii) the integration theorem associated with random thinning of a counting process. Convergence to the diffusion process limit for the appropriate se- quence of scaled queueing processes is obtained by applying the continuous mapping theorem. A key FCLT and a key FWLLN in this framework are established both with and without applying martingales.
A Vision for Enhancing Multimorbid Care using Clinical Decision Support Systems

There has been a substantial increase in Multimorbidity, worldwide. Extensive empirical research has found that General Practitioners (GPs) often feel overwhelmed when dealing with such patients [1]. While clinical decision support systems (CDSS) are effective at reducing clinical decision errors and improving healthcare processes across diverse settings [2], the use of CDSS within multimorbidity care is under investigated. This study employs a multi-method approach to examine how well CDSS currently support Irish GPs when dealing with multimorbid patients. The findings uncover a number of inadequacies, including: a lack of provision of integrated medical guidelines for multiple chronic diseases within current CDSS; and an inability to centralise the patient rather than the disease using such systems. This research underlines the need for further research into CDSS for multimorbidity and highlights key issues that must be addressed in order to improve how CDSS support the care of multimorbid patients.
Combining Lexical Semantic Resources with Question & Answer Archives for Translation-Based Answer Finding

Monolingual translation probabilities have recently been introduced in retrieval models to solve the lexical gap problem. They can be obtained by training statistical translation models on parallel monolingual corpora, such as question-answer pairs, where answers act as the "source" language and questions as the "target" language. In this paper, we propose to use as a parallel training dataset the definitions and glosses provided for the same term by different lexical semantic resources. We compare monolingual translation models built from lexical semantic resources with two other kinds of datasets: manually-tagged question reformulations and question-answer pairs. We also show that the monolingual translation probabilities obtained (i) are comparable to traditional semantic relatedness measures and (ii) significantly improve the results over the query likelihood and the vector-space model for answer finding.
Risk Factors for Coronary Drug-Eluting Stent Thrombosis: Influence of Procedural, Patient, Lesion, and Stent Related Factors and Dual Antiplatelet Therapy

The complication of stent thrombosis (ST) emerged at a rate of 0.5% annually for first-generation drug-eluting stents (DES), often presenting as death or myocardial infarction. Procedural factors such as stent underexpansion and malapposition are risk factors for ST in patients. The type of lesion being treated and lesion morphology also influence healing after treatment with DES and can contribute to ST. Second-generation DES such as the XIENCE V everolimus-eluting stent differ from the first-generation stents with respect to antiproliferative agents, coating technologies, and stent frame. Improvements in stent structure have resulted in a more complete endothelialization, thereby decreasing the incidence of ST. Bioresorbable scaffolds show promise for restoring vasomotor function and minimizing rates of very late ST. Post-PCI treatment with aspirin and clopidogrel for a year is currently the standard of care for DES, but high-risk patients may benefit from more potent antiplatelet agents. The optimal duration of DAPT for DES is currently unclear and will be addressed in large-scale randomized clinical trials.
Loves, Suffering and Identification: the Passions of Australian Football League Fans

The people of Melbourne are renowned for their ‘football fever’, yet this fever is under-studied. This paper addresses this fever by exploring the loves, suffering, and strange identifications of Australian Football League fans. Building on and complicating Freud's theories of group psychology, I argue that love, or rather two loves, are at the heart of the experience of being a fan. Fans love their club in a manner that incorporates the club into their sense of self, with the club becoming an ideal that is to be served. This love facilitates a particular form of identification where fans experience the club's trials, tribulations and triumphs, as if they too were being subjected to them. Moreover, in identifying with their club through love, the fan also takes on a second love, that of the club's object of desire, the elusive premiership. This is the love of the conquest and pursuit, a love that entails pain and suffering.
Frame level rate control based on support vector machine in HEVC

This paper proposes a frame level rate control scheme for HEVC based on support vector machine. Firstly, textual features of frames are extracted from video sequence. According to different complexities of textual features, support vector machine is chosen as a classifier for video classification. Secondly, a frame level rate control scheme is proposed to achieve higher coding efficiency based on classification results. According to the experiment results, the proposed algorithm achieves better coding performance than the original rate control scheme JCTVC-K0103 in HEVC.
SIW beamforming of 2 × 2 and 4 × 4 AFLTSA arrays for MMW applications

In this paper, a beamforming technique using multimode section based on s-parameters has been analyzed for antipodal fermi-linear tapered slot antenna (AFLTSA). The analysis is proposed for 2 × 2 and 4 × 4 sub arrays on Rogers 5880 substrate with a relative dielectric permittivity εr=2.2 in order to achieve an objective of high gain and narrow beamwidth, which can be used for target tracking and precise detection applications. The solution frequency is chosen as 32.5 GHz which yields 3 dB beamwidth of ~ 20° and ~13° for 2 × 2 and 4 × 4 AFLTSA structures respectively. The realized gain achieved for these two structures is 12.39 dB and 14.19 dB respectively. The simulation results for multimode section and sub array antenna structures are presented using Ansoft HFSS simulation tool.
Processos de resiliencia no contexto de hospitalizaçao: Um estudo de caso

This article presents a theoretical revision and a critical discussion, from a clinical case, about resilience concept in the hospitalization context. Scielo and BVS-Psi based the literature review. Resilience, as individual capacity to face risk situations in a healthy way, presenting adaptive answers to adversities, it is an important concept to be understood by health professionals. Analyzing sickness during hospitalization period in general hospitals, allows a better understanding of facilitating conditions to resilience and open possibilities for prevention work and health promotion in these institutions.