Miracle-dz/UniFAR-FTUs huggingface dataset:
Integrated Local Wisdom with 21st – Century Skills for Arabic-Speaking Material Model

The purpose of this study was to develop an integrated model of Arabic-speaking teaching materials with 21st-century skills and the value of local wisdom. This study used a mixed method approach, combining research and development techniques (R and D) using the Borg and Gall model. Participants were teachers (to do the peer assessment of the product / n = 3), experts (Arabic materials, curriculum / n = 2), and students (to get the needs analysis / n = 100). Data collection techniques include observations, questionnaires, tests, documents, and interviews. Data analysis uses qualitative and quantitative techniques. The results of this show that the model of teaching materials that have been developed is feasible to be applied in Arabic-speaking classes. The findings also show that the designed teaching materials have local wisdom values that can act as authentic materials. These teaching materials can not only build 21st-century skills but also build character education through the value of local wisdom. So, teaching materials that are integrated with the skills needs of the 21st century can facilitate learning objectives in producing quality graduates.
Whole-body analysis of TRPML3 (MCOLN3) expression using a GFP-reporter mouse model reveals widespread expression in secretory cells and endocrine glands

TRPML3 (mucolipin 3, MCOLN3) is an endolysosomal cation channel belonging to the TRPML subfamily of transient receptor potential channels. Gain-of-function mutations in the Trpml3 gene cause deafness, circling behavior and coat color dilution in mice due to cell death of TRPML3-expressing hair cells of the inner ear or skin melanocytes, respectively. Furthermore, TRPML3 was found to play a role in the long term survival of cochlear hair cells (its absence contributing to presbycusis), in specialized giant lysosomes that neonatal (birth to weaning) enterocytes used for the uptake and digestion of maternal milk nutrients, and in the expulsion of exosome-encased bacteria such as uropathogenic E. coli, infecting bladder epithelial cells. Recently, TRPML3 was found to be expressed at high levels in alveolar macrophages and loss of TRPML3 results in a lung emphysema phenotype, confirmed in two independently engineered Trpml3 knockout lines. TRPML3 is not ubiquitously expressed like its relative TRPML1 and thus cellular expression of TRPML3 on a whole-tissue level remains, with the exceptions mentioned above, largely elusive. To overcome this problem, we generated a τGFP reporter mouse model for TRPML3 and compared expression data obtained from this model by immunofluorescence on tissue sections with immunohistochemistry using TRPML3 antibodies and in situ hybridization. We thus uncovered expression in several organs and distinct cell types. We confirmed TRPML3 expression in both neonatal and adult alveolar macrophages, in melanocytes of hair follicles and glabrous skin, in principle cells of the collecting duct of the neonatal and adult kidney, and in olfactory sensory neurons of the olfactory epithelium, including its fibres protruding to the glomeruli of the olfactory bulb. Additionally, we localized TRPML3 in several glands including parathyroid, thyroid, salivary, adrenal, and pituitary gland, testes and ovaries, suggestive of potential roles for the channel in secretion or uptake of different hormones.
Flow through a Porous Wall with Convective Acceleration

This paper deals with the flow in very porous media when the convective acceleration of the flow cannot be neglected. The governing equations are taken to be a generalized Darcy's law which takes the convection term into account in the porous region and Euler's equation in the pure fluid region. Two types of flow are investigated in detail: One is a one-dimensional flow streaming into or out of a plane porous wall with a tangential component of velocity to the surface and the other is a two-dimensional stagnation point flow through a porous wall. It is found that vorticity is created when the flow crosses the surface of the wall obliquely. It is also shown that there may be the case in which the usual Darcy's law is inaccurate to describe the flow even when the permeability of the porous medium is very small.
Avian Alarm Calls Do Not Induce Anti-Predator Response in Three Anuran Species

Simple Summary Many birds and mammals are capable of eavesdropping on heterospecific alarm calls, yet it remains unclear whether other taxa (e.g., amphibians) can exploit such acoustic signals. Here, we tested whether three anuran species showed anti-predator response (e.g., escaping behavior) to territory song and different alarm calls of Japanese Tits (Parus minor). We found that all species performed no response to the territory song and alarm calls. In spite of negative results, this study provides valuable information on the cognitive processes of amphibian species. Abstract Many species produce alarm calls in response to predators, and the anti-predator signals are often used by other species. Eavesdropping on heterospecific alarm calls has been widely found in bird and mammal species. Other taxa, such as reptiles and amphibians, however, receive limited attention at present. Here, we selected three types of alarm calls of Japanese Tits (Parus minor) that were evoked by the Siberian Chipmunk (Eutamias sibiricus), Eurasian Sparrow Hawk (Accipiter nisus), and model snake (Elaphe spp.), respectively, and then carried out playback experiments to test whether three frog species changed their behaviors in response to the three treatments of Japanese Tit calls while the tit’s territory song was used as a control. The results showed that Little Torrent Frogs (Amolops torrentis), Ornamented Pygmy Frogs (Microhyla fissipes) and Spot-legged Treefrogs (Polypedates megacephalus) did not jump off their positions in response to the same four acoustic signals. They also did not change their calling behaviors in response to the alarm calls of Japanese Tits. This study found no evidence that these anuran species can eavesdrop on heterospecific tits’ alarm signals.
Digoxigenin‐labeled RNA probes for untranslated regions enable the isoform‐specific gene expression analysis of myosin heavy chains in whole‐mount in situ hybridization

Myosin heavy chains (MyHCs), which are encoded by myosin heavy chain (Myh) genes, are the most abundant proteins in myofiber. Among the 11 sarcomeric Myh isoform genes in the mammalian genome, seven are mainly expressed in skeletal muscle. Myh genes/MyHC proteins share a common role as force producing units with highly conserved sequences, but have distinct spatio‐temporal expression patterns. As such, the expression patterns of Myh genes/MyHC proteins are considered as molecular signatures of specific fiber types or the regenerative status of mammalian skeletal muscles. Immunohistochemistry is widely used for identifying MyHC expression patterns; however, this method is costly and is not ideal for whole‐mount samples, such as embryos. In situ hybridization (ISH) is another versatile method for the analysis of gene expression, but is not commonly applied for Myh genes, partly because of the highly homologous sequences of Myh genes. Here we demonstrate that an ISH analysis with the untranslated region (UTR) sequence of Myh genes is cost‐effective and specific method for analyzing the Myh gene expression in whole‐mount samples. Digoxigenin (DIG)‐labeled antisense probes for UTR sequences, but not for protein coding sequences, specifically detected the expression patterns of respective Myh isoform genes in both embryo and adult skeletal muscle tissues. UTR probes also revealed the isoform gene‐specific polarized localization of Myh mRNAs in embryonic myofibers, which implied a novel mRNA distribution mechanism. Our data suggested that the DIG‐labeled UTR probe is a cost‐effective and versatile method to specifically detect skeletal muscle Myh genes in a whole‐mount analysis.
Role of aerobics exercise and kettlebell training improving on selected health related physical fitness parameters in obese male adults

Background: Aerobics exercise training and kettlebell training is recommended to prevent and control overweight/obesity. Purpose: The aim of the this research is to assess the improvement in various variables related to health fitness among obese adults on administrating a twelve weeks aerobics exercise training and kettlebell training. Materials and Methods: Total sixty male adults with obese (Mean ± SD; age: 18.92 ± 1.54 yrs.; height: 172.4 ± 5.4 cm.; weight: 84.4 ± 6.3 kg) were randomly allocated into three equal (n = 20) groups: Aerobic Exercise Training (AET), Kettlebell Training (KBT) and a control group. The AET & KBT training protocol was performed three days per week for 12 weeks. All the selected variables of physical fitness has been examined at baseline and 12 weeks. Control group does not perform any exercise. Analysis and findings: There were significant difference in terms of Flexibility (F), Muscular Endurance (ME), Muscular Strength (MS) and Cardiovascular Endurance (CE), between the AETG & KBTG have been compared with control group (p < 0.05). Body Composition (BF) significant reductions in AET & KBT groups have been compared with control group (p < 0.05). Conclusion: Our findings suggest that AET & KBT protocols have greater effects than control group on health related physical fitness variables in obese male adult individuals. It is recommended that schools and colleges should administrate the aerobic exercise session and kettlebell training among adults for better health perspectives.
Effects of concurrent exercise on health-related quality of life in middle-aged women

Abstract Objective This study aimed to evaluate the influence of a 16-week concurrent exercise program on health-related quality of life in middle-aged women. Methods A total of 150 middle-aged women from the FLAMENCO project (age range 45–60 years) were randomized into a counseling (n = 75) or an exercise (n = 75) group. The exercise group followed a 16-week (3 days/week, 60 min/session) concurrent exercise program (aerobic + resistance training). The counseling group attended conferences on a healthy lifestyle. Participants’ health-related quality of life was assessed with the EuroQol plus, a visual analog scale and the 36-item Short Form Health Survey (SF-36), where greater values indicate a better health-related quality of life. Results The visual analog scale increased by 9.0% in the exercise group, whereas it only increased by 3.5% in the counseling group (p = 0.040). The SF-36 physical function, physical role, bodily pain, vitality and emotional role increased by 5.5%, 11.3%, 10.8%, 9.6% and 8.9%, respectively, in the exercise group, whereas these only increased by 0.6%, decreased by 0.7% and increased by 1.4%, 3.8% and 0.6% in the counseling group (all p < 0.05). Conclusions Our results suggest that a 16-week concurrent exercise program adapted for midlife women improved their health-related quality of life. ClinicalTrials.gov Identifier NCT02358109. Date of registration: 05/02/2015
Proteomic and Transcriptomic Landscapes of Alström and Bardet–Biedl Syndromes

Alström syndrome (ALMS) and Bardet–Biedl syndrome (BBS) are rare genetic diseases with a number of common clinical features ranging from early-childhood obesity and retinal degeneration. ALMS and BBS belong to the ciliopathies, which are known to have the expression products of genes, encoding them as cilia-localized proteins in multiple target organs. The aim of this study was to perform transcriptomic and proteomic analysis on cellular models of ALMS and BBS syndromes to identify common and distinct pathological mechanisms present in both syndromes. For this purpose, epithelial cells were isolated from the urine of patients and healthy subjects, which were then cultured and reprogrammed into induced pluripotent stem (iPS) cells. The pathways of genes associated with the metabolism of lipids and glycosaminoglycan and the transport of small molecules were found to be concomitantly downregulated in both diseases, while transcripts related to signal transduction, the immune system, cell cycle control and DNA replication and repair were upregulated. Furthermore, protein pathways associated with autophagy, apoptosis, cilium assembly and Gli1 protein were upregulated in both ciliopathies. These results provide new insights into the common and divergent pathogenic pathways between two similar genetic syndromes, particularly in relation to primary cilium function and abnormalities in cell differentiation.
Contouring of Structured Points With Small Features

As one type of structured points, the layered depth-normal images (LDNIs) is a discrete representation of solid models. It uses sampling points to sparsely encode the shape boundary in three orthogonal directions. Geometric modeling operations on the LDNIs solids can be performed robustly and easily. However, it is generally challenging to faithfully reconstruct the boundary representation (B-Rep) from the LDNIs solid especially for features whose sizes are close to the resolution of sampling points. In this paper, we present a novel contouring method to generate boundary surfaces from a LDNIs solid. In our method, we first consistently classify the inside/outside status of all the nodes and accordingly verify the Hermite data of sampling points. We then individually construct a set of contour edges on each cell face. We illustrate that complex shells can be more easily handled by using the approach of constructing contour edges. In addition, we develop simple and effective approaches to address the topology ambiguity cases that are typical in the contouring process. By forming the contour edges into contour loops, we can construct 2-manifold polygonal mesh surfaces for the LDNIs solid. Compared to other contouring methods, the proposed method can faithfully capture all the features that are 1-dimensionally smaller than the sampling resolution. We report experimental results on a variety of CAD models.Copyright © 2010 by ASME
Opposing mixed convection flow in a wall jet over a horizontal plate

The coupling of the temperature and velocity fields by buoyancy in a laminar two-dimensional wall jet over a finite-length horizontal plate is studied numerically and analytically in the asymptotic limit of infinite Reynolds number. Two configurations are considered leading to a cold layer of fluid over the plate, namely an ambient-temperature jet over a cooled plate and a cold jet over an insulated plate. In both cases buoyancy generates an adverse pressure gradient that may separate the flow if the Froude number is sufficiently small and always makes the solution everywhere over the plate dependent on the conditions at the downstream boundary. In the limit of very small Froude number separation occurs in a viscous–inviscid interaction region near the origin of the jet, leading to a separation bubble that covers a fraction of the plate dependent on the Prandtl number. The scalings of the solution in this asymptotic limit are obtained by order of magnitude estimations in the different regions of the bubble and in the buoyancy-dominated flow beyond the bubble, and the results are checked against the numerical solutions of the boundary layer equations. A separate analysis is carried out for very large Prandtl numbers showing that the recirculation bubble is then much shorter than the plate, also in agreement with the numerical results.
Genome-Wide Identification of Wheat KNOX Gene Family and Functional Characterization of TaKNOX14-D in Plants

The KNOX genes play important roles in maintaining SAM and regulating the development of plant leaves. However, the TaKNOX genes in wheat are still not well understood, especially their role in abiotic stress. In this study, a total of 36 KNOX genes were identified, and we demonstrated the function of the TaKNOX14-D gene under mechanical injury and cold stress. Thirty-six TaKNOX genes were divided into two groups, and thirty-four TaKNOX genes were predicted to be located in the nucleus by Cell-PLoc. These genes contained five tandem duplications. Fifteen collinear gene pairs were exhibited in wheat and rice, one collinear gene pair was exhibited in wheat and Arabidopsis. The phylogenetic tree and motif analysis suggested that the TaKNOX gene appeared before C3 and C4 diverged. Gene structure showed that the numbers of exons and introns in TaKNOX gene are different. Wheat TaKNOX genes showed different expression patterns during the wheat growth phase, with seven TaKNOX genes being highly expressed in the whole growth period. These seven genes were also highly expressed in most tissues, and also responded to most abiotic stress. Eleven TaKNOX genes were up-regulated in the tillering node during the leaf regeneration period after mechanical damage. When treating the wheat with different hormones, the expression patterns of TaKNOX were changed, and results showed that ABA promoted TaKNOX expression and seven TaKNOX genes were up-regulated under cytokinin and auxin treatment. Overexpression of the TaKNOX14-D gene in Arabidopsis could increase the leaf size, plant height and seed size. This gene overexpression in Arabidopsis also increased the compensatory growth capacity after mechanical damage. Overexpression lines also showed high resistance to cold stress. This study provides a better understanding of the TaKNOX genes.
Pediatric Acute Respiratory Distress Syndrome: Approaches in Mechanical Ventilation

Unauthorized reproduction of this article is prohibited Copyright © 2023 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. Unauthorized reproduction of this article is prohibited e104 www.pccmjournal. org February 2023 • Volume 24 • Number 2 DOI: 10.1097/PCC.0000000000003138 Copyright © 2022 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies Pablo Cruces, MD1–3 ONLINE PCCM CONCISE CLINICAL PHYSIOLOGY REVIEW
Photoionization cross section and intersublevel transitions in a one-and two-electron spherical quantum dot with a hydrogenic impurity

A detailed investigation of the optical properties of a spherical quantum dot QD containing one and two electrons has been performed for cases with and without a hydrogenic impurity. First, the photoionization cross section of both D0 and D− impurities in the QD has been calculated for an on-center impurity. Second, the intersublevel optical absorption and oscillator strength between the ground and excited states have been examined based on the computed energies and wave functions. The full numeric matrix diagonalization technique has been employed in determining sublevel energy eigenvalues and their wave functions. The PoissonSchrodinger equations have been solved self-consistently in the Hartree approximation. In addition, quantummechanical many-body effects have been investigated in the local density approximation. The results are presented as a function of quantum dot radii and photon energies.
EFFECT OF FILM ELASTICITY ON THE DRIFT VELOCITY OF CAPILLARY-GRAVITY WAVES

The effect of an insoluble, elastic surface film on the drift velocity of capillary–gravity waves is studied theoretically on the basis of a Lagrangian description of motion. There is no forcing from the atmosphere, and the wave amplitude is taken to attenuate in time. Defining a nondimensional parameter α, which combines film elasticity, fluid viscosity, and wave frequency, maximum damping of the linear waves occurs when α=1 (the Marangoni effect). In this case the frequency of capillary–gravity waves nearly coincides with that of elastic film waves. The nonlinear drift velocity is obtained for general values of α. In particular, it is found that the absolute maximum of the transient drift current is located below the surface when α≳2/3. At the surface, maximum drift velocity (in time domain) occurs for values of α that are somewhat less than one.
Algorithms for minimising the lost flow due to failed components in repairable flow networks with complex topology

A number of fundamental theorems related to non-reconfigurable repairable flow networks have been stated and proved. For a specified source-to-sink path, the difference between the sum of the unavailabilities of its forward edges and the sum of the unavailabilities of its backward edges is the path resistance. In a repairable flow network, the absence of augmentable cyclic paths with negative resistance is a necessary and sufficient condition for a minimum lost flow due to edge failures. For a specified source-to-sink path, the difference between the sum of the hazard rates of its forward empty edges and the sum of the hazard rates its backward empty edges is the flow disruption number of the path. The absence of augmentable cyclic paths with a negative flow disruption number is a necessary and sufficient condition for a minimum probability of undisturbed throughput flow, by edge failures.
Atomistic Simulation of the Buckling Behavior of Metal Nanorod

The approach of molecular dynamics simulation is one of the most promising methods for investigating the mechanical behavior of nanostructures, such as nanorods and nanowires, which are used to design nano-devices. The mechanical behavior of a copper nanorod subjected to axial compressive force is simulated using the embedded atom method (EAM). The results obtained show that the mechanical behavior in nanoscale is very different from that in macrosclae. This is due to size and surface effects. It has been found that when the external axial force is below certain critical value, the nanorod contracts in length. However, when the force reaches the critical value, the rod exhibits transverse bending, which is known as buckling. After reaching the critical value, the nanorod is able to withstand further increase in external loading and remains stable, which is so called post-buckling. When the external loading is too big, the nanorod collapses.
Observed Dielectric Waveguide Modes in the Visible Spectrum

The direct images and the radiation patterns of the first few lowest-order dielectric waveguide modes were observed in the visible region of the spectrum for fibers with core and cladding indexes of refraction of 1.56 and 1.52, respectively, and for core diameters from 0.1 to 5.5 μ. The cutoff wavelengths for the observed modes are in reasonably good agreement with theory. Photographs of the modes are shown.