Miracle-dz/UniFAR-FTUs huggingface dataset:
Stakeholder Pressure, Organizational Size, and the Allocation of Departmental Responsibility for the Management of Corporate Charitable Giving

Based on new survey evidence, this article analyzes the allocation of departmental responsibility for the management of corporate charitable giving within a sample of large U.K. companies. Several qualitatively different forms of management are identified, and a model of the determinants of the choice among these forms is estimated. The findings indicate that the allocation of internal responsibility for the management of corporate giving is significantly influenced by the extent and type of managerially perceived stakeholder pressures, organizational size, and industry characteristics. The evidence indicates that, given the firm is sufficiently large to delegate the management of its charitable contributions, the choice over the location of control is largely a function of the nature of the prevailing forms of stakeholder pressure experienced by the organization.
Divestment, Entrepreneurial Incentives, and the Life Cycle of the Firm

An entrepreneur who wants to divest his firm suffers a time-inconsistency problem: divesting a stake creates an incentive to divest further since he does not internalize the arising agency costs for the stake already sold. This paper shows that this leads to excessive divestment in equilibrium and entails efficiency losses which can offset "any" potential divestment gains. As a result, firms may stay private even if there are large gains from going public. We show that venture capitalists can reduce these inefficiencies. This is because they have influence over a firm's divestment decisions and can distinguish between an excessive and a desirable dilution of equity (such as in response to liquidity shocks). We also show that the divestment inefficiency gives rise to an optimal time of going public, which trades off the gains from going public early (higher divestment gains) with its costs (higher divestment inefficiency). Copyright (c) 2010 Blackwell Publishing Ltd.
Varieties of Undeclared Work in European Societies

Until recently, undeclared work was understood as largely the result of tax evasion by employers and workers. However, this viewpoint fails to do justice to the complexity of the phenomenon. The category of undeclared work covers several distinct types of employment relation which arise from different motives and strategies of firms, workers and contractors, and their interplay. There is no uniform logic of development. This article introduces a new typology of undeclared work and shows how the development of the different types of undeclared work can be explained by the ways in which they are embedded in a variety of institutional, cultural and socio-structural contexts.
PD-1 blockade in tumors with mismatch repair deficiency.

LBA100 Background: Somatic mutations have the potential to be recognized as "non-self" immunogenic antigens. Tumors with genetic defects in mismatch repair (MMR) harbor many more mutations than tumors of the same type without such repair defects. We hypothesized that tumors with mismatch repair defects would therefore be particularly susceptible to immune checkpoint blockade. METHODS We conducted a phase II study to evaluate the clinical activity of anti-PD-1, pembrolizumab, in 41 patients with previously-treated, progressive metastatic disease with and without MMR-deficiency. Pembrolizumab was administered at 10 mg/kg intravenously every 14 days to three cohorts of patients: those with MMR-deficient colorectal cancers (CRCs) (N = 11); those with MMR-proficient CRCs (N = 21), and those with MMR-deficient cancers of types other than colorectal (N = 9). The co-primary endpoints were immune-related objective response rate (irORR) and immune-related progression-free survival (irPFS) at 20 weeks. RESULTS The study met its primary endpoints for both MMR-deficient cohorts. The irORR and irPFS at 20 weeks for MMR-deficient CRC were 40% and 78%, respectively, and for MMR-deficient other cancers were 71% and 67%, respectively. In MMR-proficient CRC, irORR and irPFS at 20 weeks were 0% and 11%, respectively. Response rates and Disease Control Rates (CR+PR+SD) by RECIST criteria were 40% and 90% in MMR-deficient CRC, 0% and 11% in MMR-proficient CRC, and 71% and 71% in MMR-deficient other cancers, respectively. Median PFS and overall survival (OS) were not reached in the MMR-deficient CRC group but was 2.2 and 5.0 months in the MMR-proficient CRC cohort (HR for PFS = 0.103; 95% CI, 0.029 to 0.373; p < 0.001 and HR for OS = 0.216; 95% CI, 0.047 to 1.000; p = 0.05). Whole exome sequencing revealed an average of 1,782 somatic mutations per tumor in MMR-deficient compared to 73 in MMR-proficient tumors (p = 0.0015), and high total somatic mutation loads were associated with PFS (p = 0.02). CONCLUSIONS MMR status predicts clinical benefit of immune checkpoint blockade with pembrolizumab. CLINICAL TRIAL INFORMATION NCT01876511.
Intertemporal Cost Allocation and Managerial Investment Incentives: A Theory Explaining the Use of Economic Value Added as a Performance Measure

This paper provides a formal analysis of how managerial investment incentives are affected by alternative allocation rules when managerial compensation is based on accounting measures of income that include allocations for investment expenditures. The main result is that there exists a unique allocation rule that always induces the manager to choose the efficient investment level. The income measure created by this allocation rule is usually referred to as residual income or economic value added.
Newly-constructed single-phase multistring multilevel inverter for fuel-cell microgrid

The objective of this paper is to construct a novel transformerless five-level multistring inverter topology for fuel-cell microgrid system. In this study, a high step-up converter is introduced as a front-end stage to improve the conversion efficiency of conventional boost converters and to stabilize the output DC voltage of various DERs such as PV and fuel cell modules for use with the simplified multilevel inverter. The simplified multilevel inverter requires only six active switches instead of the eight required in the conventional H-bridge cascaded multilevel inverter. In addition, two active switches are operated under line frequency. The presented multistring inverter offers strong advantages such as improved output waveforms, smaller filter size, and lower EMI and THD. Experimental results show the effectiveness of the proposed solution.
Perkinsus marinus tissue distribution and seasonal variation in oysters Crassostrea virginica from Florida, Virginia and New York.

Perkinsus marinus infection intensity was measured in eastern oysters Crassostrea virginica collected in October and December 1993, and March, May, and July 1994 from 3 U.S. sites: Apalachicola Bay (FL), Chesapeake Bay (VA), and Oyster Bay (NY). Gill, mantle, digestive gland, adductor muscle, hemolymph, and remaining tissue (including gonadal material and rectum) were dissected from 20 oysters from each site at each collection time. Samples were separately diagnosed for P. marinus infections by incubation in Ray's Fluid Thioglycollate Medium (RFTM) and subsequent microscopic quantification of purified enlarged hypnospores. At all sampling times and sites, average P. marinus infection intensity (g wet wt tissue-1 or ml hemolymph-1) was lowest in hemolymph samples, and generally highest in the digestive gland. Perkinsus marinus prevalence was 100% at both FL and NY sites for each of the 5 collection times, and, for the VA site, was less than 100% in only 1 month (May 1994). Seasonal intensity patterns and mean total body burdens differed among the sites. Average body burden was highest in VA during October and progressively declined to a minimum in May. This decline was probably due to mortality of heavily infected oysters and diminution of parasite activity associated with colder temperatures and reduced salinities. Intensities varied little during the months of October and December at both the FL and NY sites. Minimum average intensities were observed in March in FL oysters and May in NY oysters. Relatively high P. marinus infection levels that persisted throughout the winter in NY oysters compared with VA oysters could reflect constant high salinity in Long Island Sound which favors parasite activity, and also rapid decline in temperature in the fall that may have prevented epizootic oyster mortalities.
Comprehensive genotype–phenotype analysis in 230 patients with tetralogy of Fallot

Background Tetralogy of Fallot (ToF), the most frequent cyanotic congenital heart disease, is associated with a wide range of intra- and extracardiac phenotypes. In order to get further insight into genotype–phenotype correlation, a large cohort of 230 unselected patients with ToF was comprehensively investigated. Methods and results 230 patients with ToF were studied by karyotyping, comprehensive 22q11.2 deletion testing and sequencing of TBX1, NKX2.5 and JAG1, as well as molecular karyotyping in selected patients. Pathogenic genetic aberrations were found in 42 patients (18%), with 22q11.2 deletion as the most common diagnosis (7.4%), followed by trisomy 21 (5.2%) and other chromosomal aberrations or submicroscopic copy number changes (3%). Mutations in JAG1 were detected in three patients with Alagille syndrome (1.3%), while NKX2.5 mutations were seen in two patients with non-syndromic ToF (0.9%). One patient showed a recurrent polyalanine stretch elongation within TBX1 which represents a true mutation resulting in loss of transcriptional activity due to cytoplasmatic protein aggregation. Conclusion This study shows that 22q11.2 deletion represents the most common known cause of ToF, and that the associated cardiac phenotype is distinct for obstruction of the proximal pulmonary artery, hypoplastic central pulmonary arteries and subclavian artery anomalies. Atrioventricular septal defect associated with ToF is very suggestive of trisomy 21 and almost excludes 22q11.2 deletion. We report a further patient with a recurrent polyalanine stretch elongation within TBX1 and for the first time link TBX1 cytoplasmatic protein aggregation to congenital heart defects.
Vigorous physical activity and depressive symptoms in college students.

BACKGROUND The purpose of this study was to examine whether college students meeting the vigorous physical activity (VPA) recommendation reported less frequent symptoms of depression than those not meeting the recommendation. METHODS A secondary analysis of the Utah Higher Education Health Behavior Survey was conducted. Descriptive statistics and unconditional logistic regressions were calculated. RESULTS The final sample included 8621 participants (age = 21.34 +/- 2.6 years). There was a difference in the frequency of depressive symptoms and VPA. Those not meeting the VPA recommendation reported having more frequent depressive symptoms than those meeting the VPA recommendation. Results were consistent by gender. CONCLUSION In this sample, our data suggest VPA may be associated with a reduction in depressive symptoms. These findings might be indicative of a dose-response relationship between VPA and symptoms of depression in college students.
Felt — A social feeling app

The idea of quantified self became a central model for management and administration of functionalities built around the interconnection of users profiles. Felt, a novel mobile social software, harnesses the interests of users for self-knowledge through self-tracking in order to record, discover, improve and share users feeling and moods.
Mixture-of-tastes Models for Representing Users with Diverse Interests

Most existing recommendation approaches implicitly treat user tastes as unimodal, resulting in an average-of-tastes representations when multiple distinct interests are present. We show that appropriately modelling the multi-faceted nature of user tastes through a mixture-of-tastes model leads to large increases in recommendation quality. Our result holds both for deep sequence-based and traditional factorization models, and is robust to careful selection and tuning of baseline models. In sequence-based models, this improvement is achieved at a very modest cost in model complexity, making mixture-of-tastes models a straightforward improvement on existing baselines.
Impact of terrorism on tourism in Turkey: empirical evidence from Turkey

This article aims at investigating the causal impact of terrorist attacks on the tourism industry in Turkey based on the Autoregressive Distributed Lag (ARDL) bounds testing procedure for the period between 1986 and 2006. The ARDL bounds test reveals that tourism is in a long-run equilibrium level relationship with terrorism. The evidence obtained from the long-run and short-run parameter estimates indicates the existence of a negative causal effect of terrorism on tourism.
Composition, Antioxidant and Antimicrobial Activities of the Leaf Essential Oil of Machilus Japonica from Taiwan

The chemical composition, and antioxidant and antimicrobial activities of the essential oil isolated from the leaf of Machilus japonica from Taiwan have been investigated. The essential oil from the fresh leaves was isolated using hydrodistillation in a Clevenger-type apparatus, and characterized by GC-FID and GC-MS. A total of 97 compounds were identified, representing 100% of the oil. The main components identified were α-phellandrene (14.5%), α-pinene (12.8%), thymol (12.6%), β-pinene (8.3%), α-terpineol (6.5%) and carvacrol (6.0%). The antioxidant activity of the oil was tested by the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging capability test. The results showed that the IC50 was 51.8 μg/mL. The antimicrobial activity of the oil was tested by the disc diffusion and micro-broth dilution methods against ten microbial species. The oil exhibited strong growth suppression against Gram-positive bacteria and yeast, with inhibition zones of 48~54 mm and MIC values of 16.12~32.25 μg/mL, respectively. For the antioxidant and antimicrobial activities of the oil, the active source compounds were determined to be thymol and carvacrol.
Friedreich's Ataxia: Autosomal Recessive Disease Caused by an Intronic GAA Triplet Repeat Expansion

Friedreich's ataxia (FRDA) is an autosomal recessive, degenerative disease that involves the central and peripheral nervous systems and the heart. A gene, X25, was identified in the critical region for the FRDA locus on chromosome 9q13. The gene encodes a 210-amino acid protein, frataxin, that has homologs in distant species such as Caenorhabditis elegans and yeast. A few FRDA patients were found to have point mutations in X25, but the majority were homozygous for an unstable GAA trinucleotide expansion in the first X25 intron.
Computational Modeling of Resting-State Activity Demonstrates Markers of Normalcy in Children with Prenatal or Perinatal Stroke

Children who sustain a prenatal or perinatal brain injury in the form of a stroke develop remarkably normal cognitive functions in certain areas, with a particular strength in language skills. A dominant explanation for this is that brain regions from the contralesional hemisphere “take over” their functions, whereas the damaged areas and other ipsilesional regions play much less of a role. However, it is difficult to tease apart whether changes in neural activity after early brain injury are due to damage caused by the lesion or by processes related to postinjury reorganization. We sought to differentiate between these two causes by investigating the functional connectivity (FC) of brain areas during the resting state in human children with early brain injury using a computational model. We simulated a large-scale network consisting of realistic models of local brain areas coupled through anatomical connectivity information of healthy and injured participants. We then compared the resulting simulated FC values of healthy and injured participants with the empirical ones. We found that the empirical connectivity values, especially of the damaged areas, correlated better with simulated values of a healthy brain than those of an injured brain. This result indicates that the structural damage caused by an early brain injury is unlikely to have an adverse and sustained impact on the functional connections, albeit during the resting state, of damaged areas. Therefore, these areas could continue to play a role in the development of near-normal function in certain domains such as language in these children.
CYP2D6*3, *4, *5 AND *6 POLYMORPHISMS AND ANTIPSYCHOTIC‐INDUCED EXTRAPYRAMIDAL SIDE‐EFFECTS IN PATIENTS RECEIVING ANTIPSYCHOTIC THERAPY

1 The aim of the present study was to examine the relationship between CYP2D6 polymorphisms and the risk of antipsychotic (AP)‐induced extrapyramidal symptoms (EPS) in patients receiving AP treatment. The allele status for CYP2D6*3, CYP2D6*4, CYP2D6*5 and CYP2D6*6 was determined in 267 patients receiving AP therapy. Seventy‐nine cases presenting with EPS (Simpson–Angus > 3) and 188 controls without EPS (Simpson‐Angus £ 3) took part in the study. 2 We found a non‐significant over‐representation of poor metaboliser genotypes among cases, but a significant association between the mutant homozygous genotype for CYP2D6*4 (odds ratio (OR) 4.1, 95% confidence interval (CI) 1.01–16, permutated P value 0.01) and the heterozygous genotype for CYP2D6*6 (OR 5.4, 95% CI 1.13–18, permutated P value 0.003) and the risk of suffering EPS. 3 These results suggest that the CYP2D6 genotype may be a contributory factor in the development of EPS in patients undergoing AP therapy.
Networked, rooted and territorial: green grabbing and resistance in Chiapas

Land grabbing has been characterized by large-scale commercial land deals or green grabs of large conservation tracts. In Chiapas, Mexico, green grabs employ a networked strategy across state, corporate and civil society lines to evict peasant and indigenous communities, and facilitate entry of extractive industries, plantations and industrial ‘ecotourism’. The resistance is rooted in place(s) and in a coalition of civil society organizations and autonomous communities. Network illustrations and field reports show that several environmental organizations occupy pivotal positions in grabbing and/or resistance networks, with large powerful groups linked to state and corporate interests. The experience in Agua Azul, a key node in a planned tourism megaproject, illustrates the deployment of networked and dispersed power to unmake and remake territories across scales. Small purchased plots form nodes in far-flung circuits of ecotourism and archeological sites. The substantial resistance is likewise rhizomatic in character, reaching across archipelagos of forest and farming communities and distant allies, to reconstitute autonomous territories. Ongoing land struggles play out in networked spaces, with entire territories, and many lives, at stake. Emerging coalitions of human rights, indigenous, religious and environmental groups promise an expanding resistance to evictions and territorial green grabs in Chiapas and elsewhere.
System Innovation in Spatial Development: Current Dutch Approaches

A system innovation is a cross-organizational qualitative intervention that various system participants bring about together through their various contributions of different kinds of knowledge and skill. The term refers to the innovation of an entire system involving many actors. Spatial development refers to both the dynamic in land use, and changes in the development and implementation of spatial plans. The current large number of societal and spatial developments taken as a whole in a country such as the Netherlands increase the pressure on space and create the need for a powerful system innovation. This paper explains the system innovation which is going on in the Netherlands now, drawing on such themes as the coproduction of policy, public–private partnership and demand management. A process architecture for area development is more and more proposed, in which project envelopes are formed, the scope is optimized and surplus profits are ploughed back into the area (value capturing). The future will tell whether this new approach will really work and whether the traditional values and performance of Dutch spatial planning will be safeguarded under changing circumstances.
A new approach based on flatness control to improve reliability of parallel connected inverters

In this paper, a global study in terms of control architecture is applied to parallel voltage-source inverters topology with common DC bus under healthy and faulty operation mode, which represents very interesting advantages for industrial applications. By paralleling several units, the power supply system is able to meet high power requirements and the possibility of maintenance during the operation without interruptible supply operation. However, a special precaution is required for such parallel systems to avoid the negative effect of the circulating currents in such configuration, caused essentially by the asynchronous switching operations of the Pulse Width Modulations (PWM) specified to each unit or existence of faults or unbalanced conditions during the operation. To deal with this crucial problem, a one loop with high bandwidth and low voltage THD controller based on the flatness technique is proposed to a non-isolated power supply composed by N units. The objective of proposed controller is to take some advantages of the flat proprieties in both healthy and faulty mode of any inverter in the parallel system, to ensure reliable operation and to ensure both reduction of the circulating currents and high power quality at the Point of Common Coupling (PCC). The algorithm is theoretically analyzed with the proposed control method and validated by the experimental results.
Optimal Polarization Demultiplexing for Coherent Optical Communications Systems

Spectrally-efficient optical communications systems employ polarization division multiplexing (PDM) as a practical solution, in order to double the capacity of a fiber link. Polarization demultiplexing can be performed electronically, using polarization-diversity coherent optical receivers. The primary goal of this paper is the optimal design, using the maximum-likelihood criterion, of polarization-diversity coherent optical receivers for polarization-multiplexed optical signals, in the absence of polarization mode dispersion (PMD). It is shown that simultaneous joint estimation of the symbols, over the two received states of polarization, yields optimal performance, in the absence of phase noise and intermediate frequency offset. In contrast, the commonly used zero-forcing polarization demultiplexer, followed by individual demodulation of the polarization-multiplexed tributaries, exhibits inferior performance, and becomes optimal only if the channel transfer matrix is unitary, e.g., in the absence of polarization dependent loss (PDL), and if the noise components at the polarization diversity branches have equal variances. In this special case, the zero-forcing polarization demultiplexer can be implemented by a 2 ? 2 lattice adaptive filter, which is controlled by only two independent real parameters. These parameters can be computed recursively using the constant modulus algorithm (CMA). We evaluate, by simulation, the performance of the aforementioned zero-forcing polarization demultiplexer in coherent optical communication systems using PDM quadrature phase shift keying (QPSK) signals. We show that it is, by far, superior, in terms of convergence accuracy and speed, compared to conventional CMA-based polarization demultiplexers. Finally, we experimentally test the robustness of the proposed constrained CMA polarization demultiplexer to realistic imperfections of polarization-diversity coherent optical receivers. The PMD and PDL tolerance of the proposed demultiplexer can be used as a benchmark in order to compare the performance of more sophisticated adaptive electronic PMD/PDL equalizers.