Miracle-dz/UniFAR-FTUs huggingface dataset:
The Circulation Response to Volcanic Eruptions: The Key Roles of Stratospheric Warming and Eddy Interactions

Proxy data and observations suggest that large tropical volcanic eruptions induce a poleward shift of the North Atlantic jet stream in boreal winter. However, there is far from universal agreement in models on this effect and its mechanism, and the possibilities of a corresponding jet shift in the Southern Hemisphere or the summer season have received little attention. Using a hierarchy of simplified atmospheric models, this study examines the impact of stratospheric aerosol on the extratropical circulation over the annual cycle. In particular, the models allow the separation of the dominant shortwave (surface cooling) and longwave (stratospheric warming) impacts of volcanic aerosol. It is found that stratospheric warming shifts the jet poleward in both the summer and winter hemispheres. The experiments cannot definitively rule out the role of surface cooling, but they provide no evidence that it shifts the jet poleward. Further study with simplified models demonstrates that the response to stratospheric warming is remarkably generic and does not depend critically on the boundary conditions (e.g., the planetary wave forcing) or the atmospheric physics (e.g., the treatment of radiative transfer and moist processes). It does, however, fundamentally involve both zonal-mean and eddy circulation feedbacks. The time scales, seasonality, and structure of the response provide further insight into the mechanism, as well as its connection to modes of intrinsic natural variability. These findings have implications for the interpretation of comprehensive model studies and for postvolcanic prediction.
Germline and somatic NF1 gene mutation spectrum in NF1‐associated malignant peripheral nerve sheath tumors (MPNSTs)

About 10% of neurofibromatosis type 1 (NF1) patients develop malignant peripheral nerve sheath tumors (MPNSTs) and represent considerable patient morbidity and mortality. Elucidation of the genetic mechanisms by which inherited and acquired NF1 disease gene variants lead to MPNST development is important. A study was undertaken to identify the constitutional and somatic NF1 mutations in 34 MPNSTs from 27 NF1 patients. The NF1 germline mutations identified in 22 lymphocytes DNA from these patients included seven novel mutations and a large 1.4‐Mb deletion. The NF1 germline mutation spectrum was similar to that previously identified in adult NF1 patients without MPNST. Somatic NF1 mutations were identified in tumor DNA from 31 out of 34 MPNSTs, of which 28 were large genomic deletions. The high prevalence (>90%) of such deletions in MPNST contrast with the ⪕20% found in benign neurofibromas and is indicative of the involvement of different mutational mechanisms in these tumors. Coinactivation of the TP53 gene by deletion, or by point mutation along with NF1 gene inactivation, is known to exacerbate disease symptoms in NF1, therefore TP53 gene inactivation was screened. DNA from 20 tumors showed evidence for loss of heterozygosity (LOH) across the TP53 region in 11 samples, with novel TP53 point mutations in four tumors. Hum Mutat 29(1), 74–82, 2008. © 2007 Wiley‐Liss, Inc.
Benchmarks, Test Beds, Controlled Experimentation, and the Design of Agent Architectures

The methodological underpinnings of AI are slowly changing. Benchmarks, test beds, and controlled experimentation are becoming more common. Although we are optimistic that this change can solidify the science of AI, we also recognize a set of difficult issues concerning the appropriate use of this methodology. We discuss these issues as they relate to research on agent design. We survey existing test beds for agents and argue for appropriate caution in their use. We end with a debate on the proper role of experimental methodology in the design and validation of planning agents.
Resolution of Gastritis Induced by Helicobacter pylori 4–5 Weeks after Successful Eradication of Infection Using a Triple Therapy Regimen of Pantoprazole, Amoxycillin and Clarithromycin for One Week

This open-label study was designed to determine the extent of histological resolution of gastritis induced by Helicobacter pylori infection 4–5 weeks after successful eradication of the infection. Eradication was achieved using a triple therapy regimen consisting of a twice daily dose of pantoprazole 40 mg, clarithromycin 500 mg, and amoxicillin 1,000 mg taken for 1 week only. No other medications were given thereafter. Four biopsies were processed for histological examination of each patient, two from the antral and two from the corporeal mucosa, first at the start of the study and then again 4 weeks after cessation of the medication trial. Scoring for H. pylori colonization and the severity of gastritis was determined for each patient according to the Sydney system. 53 of 57 patients in this study had their H. pylori infection successfully eradicated by the regimen mentioned and could be histologically evaluated. According to the severity of gastritis in the antral mucosa, patients were studied in 3 groups: mild, moderate and severe gastritis. 17 of 19 cases with mild gastritis showed complete resolution of the inflammation, with residual inflammatory changes persisting in 2 cases only. 22 of the 26 cases with moderate gastritis showed almost complete recovery except for minor residual inflammatory changes as judged by irregularity of intracytoplasmic mucine storage. Persistent residual inflammatory changes in the lamina propria were detected in 4 cases. Of the 8 cases with severe gastritis 5 showed subsidence of the inflammatory changes, but the mucosa in these cases revealed some scarring, distortion of the glandular epithelium and atrophy. In 3 cases residual inflammation persisted. Conclusion: One-week therapy with a twice daily dose of pantoprazole 40 mg, clarithromycin 500 mg and amoxicillin 1,000 mg, used to eradicate H. pylori causing active inflammation of the gastric mucosa, has led to subsidence of the acute inflammatory changes in all the cases with residual inflammation persisting in 17%. Severe gastritis may cause irreparable damage to the gastric mucosa. The density of H. pylori colonization does not appear to be related to the severity of gastritis, nor to the successful eradication achieved.
Explaining World Wide Web Traffic Self-Similarity

Abstract Recently the notion of self-similarity has been shown to apply to wide-area and local-area network traffic. In this paper we examine the mechanisms that give rise to self-similar network traffic. We present an explanation for traffic self-similarity by using a particular subset of wide area traffic: traffic due to the World Wide Web (WWW). Using an extensive set of traces of actual user executions of NCSA Mosaic, reflecting over half a million requests for WWW documents, we show evidence that WWW traffic is self-similar. Then we show that the self-similarity in such traffic can be explained based on the underlying distributions of WWW document sizes, the effects of caching and user preference in file transfer, the effect of user ``think time'''', and the superimposition of many such transfers in a local area network. To do this we rely on empirically measured distributions both from our traces and from data independently collected at over thirty WWW sites.
Stories of change: How educators change their practice

Innovative tools and teaching practices often fail to be adopted by educators in the field, despite evidence of their effectiveness. Naïve models of educational change assume this lack of adoption arises from failure to properly disseminate promising work, but evidence suggests that dissemination via publication is simply not effective. Instead of studying the adoption or rejection of a particular intervention, this paper turns the problem around. We asked educators to describe changes they had made to their teaching practice and analyzed the resulting stories to learn more about: the kinds of changes being made, their motivations for changing their practice, and the means by which they learned of pedagogical innovations. Of the 99 change stories analyzed, only three demonstrate an active search for new practices or materials on the part of teachers, and published materials were consulted in just eight of the stories. Most of the changes occurred locally, without input from outside sources, or involved only personal interaction with other educators. These results have important implications for educational developers, or researchers wishing to propagate information about new teaching materials or techniques.
Moving socio-hydrologic modelling forward: unpacking hidden assumptions, values and model structure by engaging with stakeholders: reply to “What is the role of the model in socio-hydrology?”*

ABSTRACT The arguments presented in Melsen et al. advance ideas in the “Panta Rhei” decade (2013–2022) of the International Association of Hydrological Sciences, which focuses on change in hydrology and society. While we reiterate that, despite acknowledged shortcomings, the enterprise of integrating societal feedbacks into hydrological models is beneficial in prediction and adaptive management, we also agree with the sentiments of the authors. In response, we offer concrete steps the socio-hydrologic community can take to educate modellers to become aware about unconscious biases embedded in model structure and clearly communicate assumptions. We stress the need for “knowledge brokers” that can help modellers work with stakeholders, instead of doing everything themselves. We also caution, however, against the danger of over-reaching. Young scholars already pay a big price by having to master both the natural and social sciences. As coupled human–water problems increase in societal importance, along with calls for more holistic thinking, we also need to promote an academic culture that rewards reaching across the aisle.
A 65MHZ switching rate, two-stage interleaved synchronous buck converter with fully integrated output filter

Design and analysis of a fully integrated two-stage interleaved synchronous buck DC-DC converter with on-chip filter inductor and capacitor is presented. The DC-DC converter is designed and fabricated in a 0.18 mum SiGe RFBiCMOS process technology and generates 1.5V-2.0V programmable output voltage supporting a maximum output current of 200mA. High switching frequency, multi-phase interleaved operation, and fast hysteretic controller reduce the filter inductor and capacitor sizes by two orders of magnitude compared to the state-of-the-art converters and enable a fully integrated converter. The fully integrated buck regulator achieves 64% efficiency while providing an output current of 200 mA
Activation of rat T lymphocytes by anti-CD2 monoclonal antibodies

Rat T cells and thymocytes were induced to proliferate by a pair of mAbs, MRC OX-54 and MRC OX-55, directed against rat CD2. Accessory cells were required but their role was not simply for crosslinking of the two mAbs, as neither MRC OX-54 nor MRC OX-55 alone, in the presence of a crosslinking second antibody, caused T cell mitogenesis. Nor could the phorbol ester PMA replace either antibody. The two mAbs recognized distinct epitopes on rat CD2; however, MRC OX-54 could partially block MRC OX-55 binding whereas the reverse situation was not seen. A further CD2 epitope was recognized by two mutually competitive mAbs, MRC OX-34 and MRC OX-53, which were not mitogenic. Neither MRC OX-34 nor MRC OX- 53 affected the binding of MRC OX-54 or MRC OX-55, yet they prevented the mitogenic effect induced by these mAbs. The presence of mAbs against CD4 and the IL-2-R also abrogated this mitogenesis, whereas an anti-CD5 mAb augmented the CD2-induced proliferation.
The Intravascular Lifespan of Monocytes

LTIIOUGFI MONOCYTES have been observed to persist for (lays or weeks in tissue culture2 and for periods up to 59 days after migration into a rabbit ear chamber,5 no direct measurements of their lifespan in the circulatiomi have been remade. The macrophages or large mononuclear cells occurring in inflammatory lesions of the skin have recemitly been shown by Volkman and Gowamis12 to l)e derived from precursors originating in the bone marrow and spleen which are transported to the inflamed site as momiocytes in the blood stream. Further experiments1’ have indicated that the monocyte lingers at the site of production for about 24 hours after the last period of DNA synthesis before emerging into the circulatiomi, whence it quickly escapes into the inflamed tissue. These observations would set a maximum imitravascular sojourn for this cell of about 5 days. The presemit study was undertaken to determine the intravascular hifespami of momiocytes in the intact animal. It is based on a principle first enumiciated by Osgood7 that if an animal is continuously infused with a material which will )ermTIa1iemithy lable all dividimig cells, the survival of the unlabeled portiomi of a population of cells gives a measure of their life span. The rate of decline of the unlabeled population will be independent of the production of n ’ v cells and can l)e determined from the absolute number of unlabeled cells, I)ut if the total population of the cells under observation remains constant the decline in per cent of unlabeled cells suffices to determine their disappearance rate.
Suppression of Breast Cancer Metastasis Using Stapled Peptides Targeting the WASF Regulatory Complex

The WASF3 gene facilitates the metastatic phenotype, and its inactivation leads to suppression of invasion and metastasis regardless of the genetic background of the cancer cell. This reliance on WASF3 to facilitate metastasis suggests that targeting its function could serve as an effective strategy to suppress metastasis. WASF3 stability and function are regulated by the WASF Regulatory Complex (WRC) of proteins, particularly CYFIP1 and NCKAP1. Knockdown of these proteins in vitro leads to disruption of the WRC and suppression of invasion. We have used mouse xenograft models of breast cancer metastasis to assess whether targeting the WRC complex suppresses metastasis in vivo. Stapled peptides targeting the WASF3-CYFIP1 interface (WAHM1) and the CYFIP1-NCKAP1 interface (WANT3) suppress the development of lung and liver metastases. Targeting these critical protein-protein interactions, therefore, could potentially be developed into a therapeutic strategy to control cancer cell invasion and metastasis.
A Conceptual Geological Model for investigating shallow sub-surface geology, Cheshire Energy Research Field Site

This report is a published product of the UK Geoenergy Observatories project (formerly known as the ESIOS project), by the British Geological Survey (BGS) and forms part of the geological characterisation of the Cheshire site. The report gives a conceptual overview of the shallow sub-surface geology around the Cheshire Energy Research Field Site, including a review of geological processes that have been active in this vicinity following the deposition of the youngest preserved bedrock in the area, the Sherwood Sandstone Group. This recent geological history has resulted in a complicated near-surface succession that influences the properties of rocks and soils. These have an effect on sub-surface flow processes and behaviour.
Induction of Cell Death in Growing Human T-Cells and Cell Survival in Resting Cells in Response to the Human T-Cell Leukemia Virus Type 1 Tax

Tax1 encoded by the human T-cell leukemia virus type 1 (HTLV-1) has been believed to dysregulate the expression of cellular genes involved in cell survival and mortality, leading to the development of adult T-cell leukemia (ATL). The function of Tax1 in ATL development however is still controversial, primarily because Tax1 induces cell cycle progression and apoptosis. To systemically understand cell growth phase-dependent induction of cell survival or cell death by Tax1, we established a single experimental system using an interleukin 2 (IL-2)-dependent human T-cell line Kit 225 that can be forced into resting phase by IL-2 deprivation. Introduction of Tax1 and HTLV-2 Tax (Tax2B) decreased mitochondrial activity alongside apoptosis in growing cells but not in resting cells. Cell cycle profile analysis indicated that Tax1 and Tax2B were likely to perturb the S phase in growing cells. Studies with Tax1 mutants and siRNA for NF-κB/RelA revealed that Tax1-mediated cell growth inhibition and apoptosis in growing Kit 225 cells depend on RelA. Interestingly, inactivation of the non-canonical NF-κB and p38 MAPK pathways relieved Tax1-mediated apoptosis, suggesting that the Tax1-NF-κB-p38 MAPK axis may be associated with apoptosis in growing cells. Inflammatory mediators such as CCL3 and CCL4, which are involved in oncogene-induced senescence (OIS), were induced by Tax1 and Tax2B in growing cells. In contrast, RelA silencing in resting cells reduced mitochondrial activity, indicating that NF-κB/RelA is also critical for Tax1-mediated cell survival. These findings suggest that Tax1-mediated cell survival and death depend on the cell growth phase. Both effects of Tax1 may be implicated in the long latency of HTLV-1 infection.
Leveraging Web 2.0 Sources for Web Content Classification

This paper addresses practical aspects of Web page classification not captured by the classical text mining framework. Classifiers are supposed to perform well on a broad variety of pages. We argue that constructing training corpora is a bottleneck for building such classifiers, and that care has to be taken if the goal is to generalize to previously unseen kinds of pages on the Web. We study techniques for building training corpora automatically from publicly available Web resources, quantify the discrepancy between them, and demonstrate that encouraging agreement between classifiers given such diverse sources drastically outperforms methods that ignore the different natures of data sources on the Web.
Feature extraction and classification of neuromuscular diseases using scanning EMG

In this study a new dataset are prepared for neuromuscular diseases using scanning EMG method and four new features are extracted. These features are maximum amplitude, phase duration at the maximum amplitude, maximum amplitude times phase duration, and number of peaks. By using statistical values such as mean and variance, number of features has increased up to eight. This dataset was classified by using multi layer perceptron (MLP), support vector machines (SVM), k-nearest neighbours algorithm (k-NN), and radial basis function networks (RBF). The best accuracy is obtained as 97.78% with SVM algorithm and 3-NN algorithm.
Design and analysis of Bluetooth scatternet for mobile multimedia applications

Purpose – To present a combination of Bluetooth handoff techniques and scatternet formation to adapt to varying topologies and traffic changes.Design/methodology/approach – Through ad hoc networking with Bluetooth, devices could participate in multiple piconets, which form the scatternet. Although the details of scatternet implementation are not specified in the Bluetooth specification, much research has been carried out to propose different models of implementation. This paper presents a combination of the techniques of handoff and scatternet formation to adapt to varying topologies and traffic changes. Analysis of network performance is presented to confirm the feasibility of real implementation.Findings – Provides a novel and practical design, compatible with Bluetooth specification, which is shown by experimental results to be an efficient design in providing a scatternet formation approach, while at the same time maintaining a low data error rate to support data and voice.Originality/value – This pap.
Microstructures, Water Contents, and Seismic Properties of the Mantle Lithosphere Beneath the Northern Limit of the Hangay Dome, Mongolia

To constrain the deformation, thermal evolution, and seismic properties of the mantle lithosphere beneath the Hangay Dome, we have analyzed the microstructures, crystal preferred orientations (CPO), and hydrogen concentrations of olivine and pyroxenes of 50 mantle xenoliths carried up by Cenozoic basalts from Zala, Haer, and Shavaryn‐Tsaram from Tariat, Mongolia. Most xenoliths are medium‐ to coarse‐grained spinel‐lherzolites, but four contain garnet + spinel. Coarse granular, highly annealed microstructures predominate. The microstructures are associated with well‐developed CPO, typical of deformation under high temperature, moderate pressure, and dry conditions. The hydrogen concentrations in olivine, orthopyroxene, and clinopyroxene are low and range around 5, 75, and 147 ppm H2O wt, respectively. Together, microstructures and CPO indicate that ductile deformation was followed by static recrystallization, which has annealed the microstructures but preserved the CPO and, hence, the anisotropy of physical properties. Lack of correlation between annealing and equilibrium temperatures suggest that the annealing is due to a long quiescence episode since the last deformation episode. Here, there is not evidence that the formation of Hangay Dome is associated with recent deformation in the lithospheric mantle. Calculated seismic properties show moderate seismic anisotropy, with fast propagation of P waves and polarization of S waves parallel to the flow direction and low birefringence for S waves propagating obliquely to the flow plane. The results are consistent with weak P wave anomalies but not with the strong low S wave velocity anomalies predicted by some tomographic models or with the high conductivity inferred from magnetotelluric data for the lithospheric mantle beneath the Hangay Dome.
Cosmic Complementarity: Joint Parameter Estimation from Cosmic Microwave Background Experiments and Redshift Surveys

We study the ability of future cosmic microwave background anisotropy experiments and redshift surveys to constrain a 13-dimensional parameterization of the adiabatic cold dark matter model. Each alone is unable to determine all parameters to high accuracy. However, considered together, one data set resolves the difficulties of the other, allowing certain degenerate parameters to be determined with far greater precision. We treat in detail the degeneracies involving the classical cosmological parameters, massive neutrinos, tensor-scalar ratio, bias, and reionization optical depth as well as how redshift surveys can resolve them. We discuss the opportunities for internal and external consistency checks on these measurements. Previous papers on parameter estimation have generally treated smaller parameter spaces; in direct comparisons to these works, we tend to find weaker constraints and suggest numerical explanations for the discrepancies.