Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of early membrane removal on regeneration of Class II furcation defects in dogs.

BACKGROUND This study evaluated the influence of early removal of an expanded polytetrafluoroethylene (ePTFE) membrane on periodontal regeneration. METHODS The third and fourth mandibular bicuspids of six healthy mongrel dogs were used. Class II furcation lesions were surgically created making lesions chronic for 21 days. Full flaps were elevated, and ePTFE membranes were adapted over the defects. The membranes were removed at 2 weeks on the experimental sides (test group [TGr]) and at 4 weeks on the control side (control group [CGr]). The dogs were sacrificed 12 weeks following placement of the membranes, and the teeth were histologically processed. Area measurements of new tissue (NT), epithelium (EP), connective tissue (CT), and new bone (NB) and linear measurements of bone height (BH) and new cementum (NC) were made. Wilcoxon signed rank test (P <0.05; N = 6) was carried out to determine differences between groups. RESULTS The area measurements (in mm2) for TGr and CGr, respectively, were as follows: 14.32 +/- 4.01 and 12.46 +/- 3.54 (NT); 0.04 +/- 0.09 and 0.01 +/- 0.04 (EP); 2.31 +/- 2.60 and 1.91 +/- 2.96 (CT); and 9.56 +/- 3.77 and 8.79 +/- 2.99 (NB). The results of the linear measurements (in mm) for TGr and CGr, respectively, were as follows: 3.85 +/- 1.21 and 4.03 +/- 0.94 (BH) and 10.91 +/- 1.72 and 10.59 +/- 1.80 (NC). There were no statistically significant differences between TGr and CGr for any measurement. CONCLUSION The early removal of ePTFE membranes in Class II furcation defects in dogs did not affect periodontal regeneration.
Psychotherapy Training and Empirical Evidence: A Resident's Conundrum

Psychotherapy training in the Queen’s University Department of Psychiatry adheres as far as possible to the Canadian Medical Education Directions for Specialists (CanMEDS) guidelines. We have didactic lectures on different theories of therapy and techniques, which include training residents to better understand doctor–patient relationships, providing a learning experience in ethics and boundary maintenance and encouraging a comprehensive understanding of each patient leading to formulation of a treatment plan from a biopsychosocial perspective. These objectives are outlined in the recently published Queen’s psychotherapy resident handbook (1).
The Effect of Familiarity with the Response Category Labels on Item Response to Likert Scales

Surveys in the social sciences often employ rating scales anchored by response category labels such as “strongly (dis)agree” or “completely (dis)agree. ” Although these labels may exert a systematic influence on responses since they are common to all items, academic research on the effect of different labels is surprisingly scarce. In order to help researchers choose appropriate category labels, we contrast the intensity hypothesis (which posits that response categories are endorsed less frequently if the labels are more extreme) with the familiarity hypothesis (which states that response categories are endorsed more frequently if the labels are more common in day-to-day language). In a series of studies we find consistent support for the familiarity hypothesis. Our results have important implications for the appropriate use of category labels in multilingual surveys, and we propose a procedure based on Internet search engine hits to equate labels in different languages in terms of familiarity.
A biomechanical comparison of the SACH, Seattle and Jaipur feet using ground reaction forces

The Jaipur prosthetic foot was developed in India in response to specific socio-cultural needs of Indian amputees. It is being used extensively in India and several other developing countries. Its claim of being a cheaper and satisfactory alternative to other prosthetic feet has not been investigated biomechanically. The present study was undertaken to compare its biomechanical properties with the SACH and Seattle feet, using ground reaction forces. Three trans-tibial amputees participated in the experiment which measured the ground reaction force data using a Kistler force plate. Subject's normal foot was used as a reference. Six variables from the vertical and anteroposterior components of ground reaction forces were quantified, their statistical analysis showed that the normal foot generates significantly larger ground reaction forces than the prosthetic foot. The shock absortion capacity of the SACH foot was found to be better when compared with the other two feet, while the Jaipur foot allowed a more natural gait and was closer in performance to the normal foot. None of the prostheses significantly influenced the locomotor style of the amputees.
Functional Characterization of Tn4401, a Tn3-Based Transposon Involved in blaKPC Gene Mobilization

ABSTRACT The carbapenemase gene blaKPC, which is rapidly spreading worldwide, is located on a Tn3-based transposon, Tn4401. In a transposition-conjugation assay, Tn4401 was able to mobilize blaKPC-2 gene at a frequency of 4.4 × 10−6/recipient cell. A 5-bp target site duplication was evidenced upon each insertion without target site specificity. This study demonstrated that Tn4401 is an active transposon capable of mobilizing blaKPC genes at high frequency.
Noncompact Coset Spaces in String Theory

A brief overview of strings propagating on noncompact coset spaces G/H is presented in terms of WZW models. The role played by isometries in the existence of target space duality and by fixed points of the gauge transformations in the existence of singularities and horizons, is emphasized. A general classification of the spaces with a single time-like coordinate is presented. The spacetime geometry of a class of models, existing for every dimension and having cosmological and black hole-like interpretations, is discussed.
relacionados con la salud en adultos mayores

This study investigated the relationship between the levels of Spiritual Well-being and the levels of Health Related Hardiness in Mexican population of abuts 65 years and older. The framework was based on the Roy adaptation model, Pollockis, Health Related Hardiness and Spiritual Well-being of Reed. The design was descriptive co relational, the sampling was probabilistic random. The sample (n=160) had a level of significance of 0.05 for a mean difference of medium 1.6, a size effect and a potency of 80. The instruments were the Health Related Hardiness Scale, with an Alpha of 0.801 and the Spiritual Well Being with an Alpha of 0.973. Multiple Linear Regression was used to investigate the effect of the demographic variables on the Spiritual Well-being. The mean age of the subjects was of 73.9 (DE=4.3) 62.5% were females. The Correlation Coefficient between Spiritual Well-being and Health Related Hardiness was r. 684 p<. 05, meaning that higher levels of Spiritual Well-being have higher levels of Health Related Hardiness. Sex, age, education, and marital status showed a positive correlation with the levels of Spiritual Well Being (p<.005). The women showed a higher level of Spiritual Well-being than the males.
Evolution and Diversity in Human Herpes Simplex Virus Genomes

ABSTRACT Herpes simplex virus 1 (HSV-1) causes a chronic, lifelong infection in >60% of adults. Multiple recent vaccine trials have failed, with viral diversity likely contributing to these failures. To understand HSV-1 diversity better, we comprehensively compared 20 newly sequenced viral genomes from China, Japan, Kenya, and South Korea with six previously sequenced genomes from the United States, Europe, and Japan. In this diverse collection of passaged strains, we found that one-fifth of the newly sequenced members share a gene deletion and one-third exhibit homopolymeric frameshift mutations (HFMs). Individual strains exhibit genotypic and potential phenotypic variation via HFMs, deletions, short sequence repeats, and single-nucleotide polymorphisms, although the protein sequence identity between strains exceeds 90% on average. In the first genome-scale analysis of positive selection in HSV-1, we found signs of selection in specific proteins and residues, including the fusion protein glycoprotein H. We also confirmed previous results suggesting that recombination has occurred with high frequency throughout the HSV-1 genome. Despite this, the HSV-1 strains analyzed clustered by geographic origin during whole-genome distance analysis. These data shed light on likely routes of HSV-1 adaptation to changing environments and will aid in the selection of vaccine antigens that are invariant worldwide.
A Tutorial on the Mechanisms, Dynamics, and Control of Atomic Force Microscopes

The atomic force microscope (AFM) is one of the most versatile tools in nanotechnology. For control engineers this instrument is particularly interesting, since its ability to image the surface of a sample is entirely dependent upon the use of a feedback loop. This paper will present a tutorial on the control of AFMs. We take the reader on a walk around the control loop and discuss each of the individual technology components. The major imaging modes are described from a controls perspective and recent advances geared at increasing the performance of these microscopes are highlighted.
The Push3 execution stack and the evolution of control

The Push programming language was developed for use in genetic and evolutionary computation systems, as the representation within which evolving programs are expressed. It has been used in the production of several significant results, including results that were awarded a gold medal in the Human Competitive Results competition at GECCO-2004. One of Push's attractive features in this context is its transparent support for the expression and evolution of modular architectures and complex control structures, achieved through explicit code self-manipulation. The latest version of Push, Push3, enhances this feature by permitting explicit manipulation of an execution stack that contains the expressions that are queued for execution in the interpreter. This paper provides a brief introduction to Push and to execution stack manipulation in Push3. It then presents a series of examples in which Push3 was used with a simple genetic programming system (PushGP) to evolve programs with non-trivial control structures.
Empowerment through sex education? Rethinking paradoxical policies

Abstract Youth empowerment is the main goal of sex education according to Dutch Government and NGO policies. Academics from different disciplines have argued, however, that the ideal of empowerment through education is problematic, because of the unequal power relations implicated in educational practices. Building on one-and-a-half years of online and offline ethnographic fieldwork among Dutch youth, this article argues that Dutch sex educational policies inhibit rather than encourage young people’s empowerment by allowing only a limited number of sexual knowledge building practices to thrive while making others nearly impossible. In order to facilitate young people’s empowerment, policies should aim to create space for young people to develop their own themes and priorities, to offer a multitude of perspectives, to set the pace and to use different strategies for sexual knowledge building, including learning by doing and online learning. This requires a cultural shift that involves both an openness to young people’s experimentation, and a change in existing power hierarchies based on age.
The Psychology of the Active Killer

Recent research has done much to delineate patterns typical of the Active Killer (Borsch, 2009). What remains wanting is a general account of why the Active Killer does what he does—that is, an explanatory framework against which we can make sense of the abiding peculiarities of Active Killer events, particularly the scale of violence, the randomness of violence, and the striking propensity to suicide. In what follows, I propose a possible framework and elicit its tactical implications. The proposal is intended to open new avenues for the exploration of what has become a vexing phenomenon of modern society.
Workshop Summary: Experiment

A summary of experimental results from the Pentaquark 2004 Workshop held at the SPring-8 facility in Japan is given. New results from the LEPS collaboration are highlighted, and older results are reviewed. Non-observations are also discussed in light of theoretical estimates of possible � + production mechanisms. The problem of the narrow width and the parity of the � + are explored and point to future experimental work that is needed.
UNMET THERAPEUTIC NEEDS IN PSORIATIC ARTHRITIS: DATA FROM THE ROMANIAN REGISTRY OF RHEUMATIC DISEASES – NEW THERAPIES AND TARGETS

The objectives of this article were to identify the potential Romanian psoriatic arthritis patients (PsA) subpopulation in need for new therapeutic principles, currently unavailable in our country. Data were retrieved electronically from the Romanian Registry for Rheumatic Diseases (RRBR) database between January 1 and December 31 2017. In order to define remission and low disease activity, patients were assessed with the Disease Activity in Psoriatic Arthritis (DAPSA) and Simplified Disease Activity Index scores. Of the 804 PsA patients enrolled in RRBR in 2017, 721 (89.7%) patients were treated with biologics for more than 6 months. Of these, 86 patients (11.9%) were in moderate and high disease activity according to DAPSA and 196 patients (27.2%) according to SDAI, respectively. Compared to patients in DAPSA remission or low disease activity, these patients had a higher toll of inflammation and a higher prevalence of sacroiliitis. Up to 30% of Romanian PsA patients registered in RRBR would be candidates for new and locally unavailable biologic and synthetic disease-modifying anti-rheumatic drugs, such as abatacept, apremilast, certolizumab, ixekizumab, tofacitinib and ustekinumab.
Memory Accumulation Mechanisms in Human Cortex Are Independent of Motor Intentions

Previous studies on perceptual decision-making have often emphasized a tight link between decisions and motor intentions. Human decisions, however, also depend on memories or experiences that are not closely tied to specific motor responses. Recent neuroimaging findings have suggested that, during episodic retrieval, parietal activity reflects the accumulation of evidence for memory decisions. It is currently unknown, however, whether these evidence accumulation signals are functionally linked to signals for motor intentions coded in frontoparietal regions and whether activity in the putative memory accumulator tracks the amount of evidence for only previous experience, as reflected in “old” reports, or for both old and new decisions, as reflected in the accuracy of memory judgments. Here, human participants used saccadic-eye and hand-pointing movements to report recognition judgments on pictures defined by different degrees of evidence for old or new decisions. A set of cortical regions, including the middle intraparietal sulcus, showed a monotonic variation of the fMRI BOLD signal that scaled with perceived memory strength (older > newer), compatible with an asymmetrical memory accumulator. Another set, including the hippocampus and the angular gyrus, showed a nonmonotonic response profile tracking memory accuracy (higher > lower evidence), compatible with a symmetrical accumulator. In contrast, eye and hand effector-specific regions in frontoparietal cortex tracked motor intentions but were not modulated by the amount of evidence for the effector outcome. We conclude that item recognition decisions are supported by a combination of symmetrical and asymmetrical accumulation signals largely segregated from motor intentions.
The Issues of Effectiveness of Advertisement Communication Process: A Case Study of Lithuania Consumers

The goal of this study was to disclose the core of the advertising research based on the psychological aspects by acquainting with the nature of advertising research and revealing the importance of psychological aspects of advertising during the advertising research. The growing interest in consumer response to advertisement served as an encouragement to make the analysis of psychological aspects of the advertising research, because the information obtained during the advertising research helps to answer the question how advertising really works. In the research analysis focuses on the nature of advertising research. The place of advertising research in advertisement planning process and the advertising research process are unfolded. Moreover, the importance of psychological aspects in the advertising research is being examined. The certain psychological aspects like the particularities of advertising communication process, psychological process that are active at advertising acceptance and awareness process as well as the advertising effects are analysed in more detail. Keywords—Advertising, communication process, advertising message, advertising psychology. I. CONCEPTUAL BACKGROUND E may treat the advertisement from two perspectives: as advertisement specialists and consumers. Advertisement specialists make decisions incident to planning, creation and conveying of the advertisement. Consumers, on the contrary, react to the advert which advertisement specialists have created and presented them. After incorporating these two perspectives we can state that constant interaction of advert and consumer is observed in the advertisement process. As marketing specialists transfer particular message to the consumers while advertise something, the advertisement may by called communication
Ten new ATM alterations in Polish patients with ataxia-telangiectasia

Inherited biallelic mutations of the ATM gene are responsible for the development of ataxia telangiectasia (AT). The objective of the present study was to conduct molecular analysis of the ATM gene in a cohort of 24 Polish patients with ataxia‐telangiectasia with aim being to provide an updated mutational spectrum in Polish AT patients. As a result of molecular analysis, the status of recurrent mutation was confirmed and ten new ATM variants were detected. Application of MLPA analysis allowed the detection of large genomic deletion. Previously, this type of mutation had never been seen in our population. Finally, in silico analysis was carried out for newly detected ATM alterations. In addition, functional analysis was performed to evaluate the effects of intronic variants: c.3402+30_3402+32delATC.
STUDY OF CONGENITALLY IMMUNOLOGIC MUTANT NEW ZEALAND MICE: V. B CELL FUNCTION OF NZB‐Xld MICE

NZB mice bearing the CBA/N X chromosome linked defect were generated by repetitive backcrossing and selection of the Xld gene. The male offspring resulting from the cross of NZB with CBA/N were selected as being XldY on the basis of sera IgM and IgG3 levels and responsiveness to DNP‐Lys‐Ficoll. Following this inbreeding protocol, 6th generation backcross NZB XldY mice were compared to littermate controls with respect to B cell function. Sera immunoglobulin levels of IgG1, IgG2a, IgG2b and IgA were similar in XldY and XY mice. In contrast, levels of IgM and IgG3, from XldY mice were approximately 15% and 50%, respectively, of values found in littermates. Furthermore, XldY mice failed to respond to DNP‐Lys‐Ficoll and had less than 3% splenic Lyb 5.1‐bearing cells. Splenic immunoglobulin cell surface profiles, obtained by the fluorescent activated cell sorter, indicated a significant reduction in the frequency of Ig bearing cells in Xld animals. Such profiles were similar to those obtained for spleen cells from reference control CBA/N mice. Finally, an elevated number of splenic, lymph node and bone marrow background and lipopolysaccharide‐induced B cell clones in semi‐solid phase agar was found in NZB but not C57BL/6, C3H, BALB/c and DBA/2 controls. In contrast, NZB XldY mice had virtually no detectable B cell colonies. This data, obtained on significantly inbred XldY NZB mice, suggests that the Xid gene is dominant over several aspects of polyclonal B cell activation in NZB mice and indicates that serial observation of these mice will be valuable in understanding the interactions of genetic immunologic mutations and cellular function in autoimmunity.
The Rise of “Economic Consequences”

Since the 1960s, the American accounting profession has been aware of the increasing influence of "outside forces" in the standardsetting process. Two parallel developments have marked this trend. First, individuals and groups that had rarely shown any interest in the setting of accounting standards began to intervene actively and powerfully in the process. Second, these parties began to invoke arguments other than those which have traditionally been employed in accounting discussions. The term "economic consequences" has been used to describe these novel kinds of arguments. By "economic consequences" is meant the impact of accounting reports on the decisionmaking behavior of business, government, unions, investors and creditors. It is argued that the resulting behavior of these individuals and groups could be detrimental to the interests of other affected parties. And, the argument goes, accounting standard setters must take into consideration these allegedly detrimental consequences when deciding on accounting questions. * The recent debates involving foreign currency translation and the accounting for unsuccessful exploration activity in the petroleum industry have relied heavily on economic consequences argu-
PERSONALITY TRAITS OF BULLIES AS A CONTRIBUTORY FACTOR IN WORKPLACE BULLYING: AN EXPLORATORY STUDY

This paper examines the relationship between personality characteristics - as indexed by the ICES Personality Inventory (Bartram, 1994; 1998) and the IBS Clinical Inventory (Mauger, Adkinson, Zoss, Firestone & Hook, 1980) - and bullying behavior. Although it proved to be difficult to obtain a large enough sample of bullies, the findings indicated that bullies are aggressive, hostile, and extraverted and independent. Furthermore, bullies are egocentric, selfish, and show little concern for the opinions of others. High levels of aggressiveness, assertiveness, competitiveness and independence are traits that are also associated with leadership.
Inactivation of Toluene 2-Monooxygenase in Burkholderia cepacia G4 by Alkynes

ABSTRACT High concentrations of acetylene (10 to 50% [vol/vol] gas phase) were required to inhibit the growth of Burkholderia cepaciaG4 on toluene, while 1% (vol/vol) (gas phase) propyne or 1-butyne completely inhibited growth. Low concentrations of longer-chain alkynes (C5 to C10) were also effective inhibitors of toluene-dependent growth, and 2- and 3-alkynes were more potent inhibitors than their 1-alkyne counterparts. Exposure of toluene-grownB. cepacia G4 to alkynes resulted in the irreversible loss of toluene- and o-cresol-dependent O2 uptake activities, while acetate- and 3-methylcatechol-dependent O2 uptake activities were unaffected. Toluene-dependent O2 uptake decreased upon the addition of 1-butyne in a concentration- and time-dependent manner. The loss of activity followed first-order kinetics, with apparent rate constants ranging from 0.25 min−1 to 2.45 min−1. Increasing concentrations of toluene afforded protection from the inhibitory effects of 1-butyne. Furthermore, oxygen, supplied as H2O2, was required for inhibition by 1-butyne. These results suggest that alkynes are specific, mechanism-based inactivators of toluene 2-monooxygenase inB. cepacia G4, although the simplest alkyne, acetylene, was relatively ineffective compared to longer alkynes. Alkene analogs of acetylene and propyne—ethylene and propylene—were not inactivators of toluene 2-monooxygenase activity in B. cepacia G4 but were oxidized to their respective epoxides, with apparentKs and Vmax values of 39.7 μM and 112.3 nmol min−1 mg of protein−1 for ethylene and 32.3 μM and 89.2 nmol min−1 mg of protein−1 for propylene.