Miracle-dz/UniFAR-FTUs huggingface dataset:
Culture and development of everyday social explanation.

The impact of cultural meaning systems on the development of everyday social explanation is explored in a cross-cultural investigation undertaken among Indian and American adults and children (ages 8, 11, and 15 year). It is demonstrated that at older ages Americans make greater reference to general dispositions and less reference to contextual factors in explanation than do Hindus . References to general dispositions also undergo a much greater developmental increase among Americans than among Hindus , whereas references to contextual factors show the opposite pattern of developmental change. Evidence suggests that these cross-cultural and developmental differences result from contrasting cultural conceptions of the person acquired over development in the two cultures rather than from cognitive. , experiential, or informational differences between attributors . Discussion focuses on theoretical implications of such a demonstration for understanding: (a) the importance of integrating semantic with structural considerations in theories of social attribution, (b) the need to develop nonteleological frameworks for interpreting age and cultural diversity in conceptualization, and (c) the role of cultural communication in the acquisition of everyday social knowledge.
Harvana: harvesting community tags to enrich collection metadata

Collaborative, social tagging and annotation systems have exploded on the Internet as part of the Web 2.0 phenomenon. Systems such as Flickr, Del.icio. us, Technorati, Connotea and LibraryThing, provide a community-driven approach to classifying information and resources on the Web, so that they can be browsed, discovered and re-used. Although social tagging sites provide simple, user-relevant tags, there are issues associated with the quality of the metadata and the scalability compared with conventional indexing systems. In this paper we propose a hybrid approach that enables authoritative metadata generated by traditional cataloguing methods to be merged with community annotations and tags. The HarvANA (Harvesting and Aggregating Networked Annotations) system uses a standardized but extensible RDF model for representing the annotations/tags and OAI-PMH to harvest the annotations/tags from distributed community servers. The harvested annotations are aggregated with the authoritative metadata in a centralized metadata store. This streamlined, interoperable, scalable approach enables libraries, archives and repositories to leverage community enthusiasm for tagging and annotation, augment their metadata and enhance their discovery services. This paper describes the HarvANA system and its evaluation through a collaborative testbed with the National Library of Australia using architectural images from PictureAustralia.
Clostridium difficile in Long-Term–Care Facilities for the Elderly

Abstract Antimicrobial agents are among the most frequently prescribed medications in long-term–care facilities (LTCFs). Therefore, it is not surprising that Clostridium difficile colonization and C. difficile-associated diarrhea (CDAD) occur commonly in elderly LTCF residents. C. difficile has been identified as the most common cause of non-epidemic acute diarrheal illness in nursing homes, and outbreaks of CDAD in LTCFs have also been recognized. This position paper reviews the epidemiology and clinical features of CDAD in elderly residents of LTCFs and, using available evidence, provides recommendations for the management of C. difficile in this setting.
Familial footpad hyperkeratosis and inheritance of keratin 2, keratin 9, and desmoglein 1 in two pedigrees of Irish Terriers.

OBJECTIVE To investigate the possibility that variants in the acidic or basic keratin genes or in desmoglein 1 may cause the clinical manifestation of familial footpad hyperkeratosis in Irish Terriers. ANIMALS 11 dogs belonging to 2 related affected pedigrees of Irish Terriers. PROCEDURE Genomic DNA was extracted from blood samples obtained from each dog. The DNA markers linked to the genes keratin 2, keratin 9, and desmoglein 1 were amplified by use of a polymerase chain reaction technique, and length of the products was determined by use of an automatic DNA analyzer. RESULTS All tested markers yielded information. None of the markers (genotype) cosegregated with the clinical status of the dogs (phenotype) in the 2 pedigrees. CONCLUSIONS AND CLINICAL RELEVANCE Mutations in the genes encoding keratin 2 and 9 as well as desmoglein 1 are highly unlikely to be the primary cause of familial footpad hyperkeratosis in Irish Terriers.
Peritubular Myoid Cells Are Not the Migrating Population Required for Testis Cord Formation in the XY Gonad

Cell migration is one of the earliest events required for development of the testis. Migration occurs only in XY gonads downstream of Sry expression and is required for the subsequent epithelialization of testis cords. Using organ culture experiments and tissue recombination, we and others speculated that peritubular myoid (PTM) cells were among the migratory cells and were likely the cell type required for cord formation. However, because no unique marker was found for PTM cells, their positive identification during or after migration remained unclear. α-Smooth Muscle Actin (αSma; approved gene symbol Acta2), a classic marker of adult PTM cells,is expressed broadly in testis interstitial cells at E12.5, and becomes highly enriched in PTM cells by E15.5–16.5. We used a novel transgenic line expressingEYFP under the control of an αSma promoter to determine whether αSma-EYFP positive cellsmigrate into the gonad. Surprisingly, mesonephroi expressing αSma-EYFP do not contribute any EYFP positive cells to XY gonads when used as donors in recombination cultures. These results indicate that αSma-EYFP cells do not migrate into the gonad during the critical window of sex determination and cannot be the migrating cell type required for testis cord formation. Our results suggest that PTM cells, and most other interstitial lineages, with the exception of endothelial cells, are induced within the gonad. These experiments suggest that endothelial cells are the migrating cell type required for epithelialization of testis cords.
Clinical profile and complications of childhood- and adolescent-onset type 2 diabetes seen at a diabetes center in south India.

OBJECTIVE This study describes the clinical characteristics of childhood- and adolescent-onset type 2 diabetes mellitus (CAT2DM) seen at a diabetes center in southern India. RESEARCH DESIGN AND METHODS Between January 1992 and December 2009, 368 CAT2DM patients were registered. Anthropometric measurements were done using standardized techniques. Biochemical investigations included C-peptide measurements and glutamic acid decarboxylase antibody assay wherever feasible. Retinopathy was diagnosed by retinal photography; microalbuminuria, if urinary albumin excretion was between 30 and 299 mg/μg of creatinine; nephropathy, if urinary albumin excretion was ≥300 mg/μg; and neuropathy, if vibration perception threshold on biothesiometry was ≥20 V. RESULTS The proportion of CAT2DM patients, expressed as percentage of total patients registered at our center, rose from 0.01% in 1992 to 0.35% in 2009 (P<0.001). Among the 368 cases of CAT2DM, 96 (26%) were diagnosed before the age of 15 years. The mean age at first visit and age at diagnosis of the CAT2DM subjects were 22.2±9.7 and 16.1±2.5 years, respectively. Using World Health Organization growth reference charts, 56% of boys and 50.4% of girls were >85(th) percentile of body mass index for age. Prevalence rates of retinopathy, microalbuminuria, nephropathy, and neuropathy were 26.7%, 14.7%, 8.4%, and 14.2%, respectively. Regression analysis revealed female gender, body mass index >85(th) percentile, parental history of diabetes, serum cholesterol, and blood pressure to be associated with earlier age at onset of CAT2DM. CONCLUSIONS CAT2DM appears to be increasing in urban India, and the prevalence of microvascular complications is high. Female predominance is seen at younger ages.
Concept Forest: A New Ontology-assisted Text Document Similarity Measurement Method

Although using ontologies to assist information retrieval and text document processing has recently attracted more and more attention, existing ontologybased approaches have not shown advantages over the traditional keywords-based Latent Semantic Indexing (LSI) method. This paper proposes an algorithm to extract a concept forest (CF) from a document with the assistance of a natural language ontology, the WordNet lexical database. Using concept forests to represent the semantics of text documents, the semantic similarities of these documents are then measured as the commonalities of their concept forests. Performance studies of text document clustering based on different document similarity measurement methods show that the CF-based similarity measurement is an effective alternative to the existing keywords-based methods. In particular, this CFbased approach has obvious advantages over the existing keywords-based methods, including LSI, in processing short text documents or in P2P or live news environments where it is impractical to collect the entire document corpus for analysis.
Localized Functionalization of Single Nanopores

We demonstrate the localization of chemical functionality at the entrance of single nanopores for the first time by using the controlled growth of an oxide ring. Nanopores were fabricated by Focused Ion Beam machining on silicon platforms, locally derivatized by ion beam assisted oxide deposition, and further functionalized with DNA probes via silane chemistry. Ionic current recorded through single nanopores at various stages of the fabrication process demonstrated that the apertures can be locally functionalized with DNA probes. Future applications for this functional platform include the selective detection of biological organisms and molecules by ionic current blockade measurements.
A general framework for low level vision

We introduce a new geometrical framework based on which natural flows for image scale space and enhancement are presented. We consider intensity images as surfaces in the (x, I) space. The image is, thereby, a two-dimensional (2-D) surface in three-dimensional (3-D) space for gray-level images, and 2-D surfaces in five dimensions for color images. The new formulation unifies many classical schemes and algorithms via a simple scaling of the intensity contrast, and results in new and efficient schemes. Extensions to multidimensional signals become natural and lead to powerful denoising and scale space algorithms.
Cadherin-dependent mechanotransduction depends on ligand identity but not affinity

Summary This study investigates the relationship between classical cadherin binding affinities and mechanotransduction through cadherin-mediated adhesions. The mechanical properties of cadherin-dependent intercellular junctions are generally attributed to differences in the binding affinities of classical cadherin subtypes that contribute to cohesive energies between cells. However, cell mechanics and mechanotransduction may also regulate intercellular contacts. We used micropipette measurements to quantify the two-dimensional affinities of cadherins at the cell surface, and two complementary mechanical measurements to assess ligand-dependent mechanotransduction through cadherin adhesions. At the cell surface, the classical cadherins investigated in this study form both homophilic and heterophilic bonds with two-dimensional affinities that differ by less than threefold. In contrast, mechanotransduction through cadherin adhesions is strongly ligand dependent such that homophilic, but not heterophilic ligation mediates mechanotransduction, independent of the cadherin binding affinity. These findings suggest that ligand-selective mechanotransduction may supersede differences in cadherin binding affinities in regulating intercellular contacts.
Assessing the root of bilaterian animals with scalable phylogenomic methods

A clear picture of animal relationships is a prerequisite to understand how the morphological and ecological diversity of animals evolved over time. Among others, the placement of the acoelomorph flatworms, Acoela and Nemertodermatida, has fundamental implications for the origin and evolution of various animal organ systems. Their position, however, has been inconsistent in phylogenetic studies using one or several genes. Furthermore, Acoela has been among the least stable taxa in recent animal phylogenomic analyses, which simultaneously examine many genes from many species, while Nemertodermatida has not been sampled in any phylogenomic study. New sequence data are presented here from organisms targeted for their instability or lack of representation in prior analyses, and are analysed in combination with other publicly available data. We also designed new automated explicit methods for identifying and selecting common genes across different species, and developed highly optimized supercomputing tools to reconstruct relationships from gene sequences. The results of the work corroborate several recently established findings about animal relationships and provide new support for the placement of other groups. These new data and methods strongly uphold previous suggestions that Acoelomorpha is sister clade to all other bilaterian animals, find diminishing evidence for the placement of the enigmatic Xenoturbella within Deuterostomia, and place Cycliophora with Entoprocta and Ectoprocta. The work highlights the implications that these arrangements have for metazoan evolution and permits a clearer picture of ancestral morphologies and life histories in the deep past.
Protein Binding of β-Lactam Antibiotics in Critically Ill Patients: Can We Successfully Predict Unbound Concentrations?

ABSTRACT The use of therapeutic drug monitoring (TDM) to optimize beta-lactam dosing in critically ill patients is growing in popularity, although there are limited data describing the potential impact of altered protein binding on achievement of target concentrations. The aim of this study was to compare the measured unbound concentration to the unbound concentration predicted from published protein binding values for seven beta-lactams using data from blood samples obtained from critically ill patients. From 161 eligible patients, we obtained 228 and 220 plasma samples at the midpoint of the dosing interval and trough, respectively, for ceftriaxone, cefazolin, meropenem, piperacillin, ampicillin, benzylpenicillin, and flucloxacillin. The total and unbound beta-lactam concentrations were measured using validated methods. Variabilities in both unbound and total concentrations were marked for all antibiotics, with significant differences being present between measured and predicted unbound concentrations for ceftriaxone and for flucloxacillin at the mid-dosing interval (P < 0.05). The predictive performance for calculating unbound concentrations using published protein binding values was poor, with bias for overprediction of unbound concentrations for ceftriaxone (83.3%), flucloxacillin (56.8%), and benzylpenicillin (25%) and underprediction for meropenem (12.1%). Linear correlations between the measured total and unbound concentrations were observed for all beta-lactams (R2 = 0.81 to 1.00; P < 0.05) except ceftriaxone and flucloxacillin. The percent protein binding of flucloxacillin and the plasma albumin concentration were also found to be linearly correlated (R2 = 0.776; P < 0.01). In conclusion, significant differences between measured and predicted unbound drug concentrations were found only for the highly protein-bound beta-lactams ceftriaxone and flucloxacillin. However, direct measurement of unbound drug in research and clinical practice is suggested for selected beta-lactams.
Effects on the murine mononuclear phagocyte system of chronic administration of liposomes containing cytotoxic drug or lipid A compared with empty liposomes.

In experiments designed to examine the adverse effects of chronic liposome administration in vivo on the mononuclear phagocyte system (reticuloendothelial system), the presence of drug entrapped in the liposomes may increase the level of reticuloendothelial impairment. We have compared the effects on the mononuclear phagocyte system in mice of chronic administration of empty liposomes with the effects of liposomes containing the anti-leishmanial drug meglumine antimoniate. We have also examined the effect on the mononuclear phagocyte system of continued injections of liposomes containing lipid A, a component of bacterial lipopolysaccharide, which is responsible for macrophage activation. Ten intravenous injections of multilamellar liposomes composed of dipalmitoylphosphatidylcholine and cholesterol (1:0.75 M ratio) were given to ICR mice over a 25-day period. Two individual groups of mice received endotoxin-free liposomes in which meglumine antimoniate was either present or absent. One addition group received liposomes containing lipid A derived from Escherichia coli lipopolysaccharide. A control group received sterile saline injections. In each group, a depression of the phagocytic index, as measured by reduction of uptake of particulate carbon, was observed among some of the individual animals 24 h after the first injection. In many mice a marked splenomegaly was observed. A depressed phagocytic index and splenomegaly were most marked for mice receiving lipid A liposomes. However, there was a large individual variability among mice receiving these preparations and some mice in each group had normal spleen size and a nearly normal phagocytic index. Tissue distribution of liposomes containing [14C]dipalmitoylphosphatidylcholine as a phospholipid marker was examined in all groups in mice 24 h after the last injection. (ABSTRACT TRUNCATED AT 250 WORDS)
Determination of Residual Fracture Toughness of Post-Fire Concrete

Determination of double-K fracture parameter using both analytical and weight function method is carried out in present research. In calculating the cohesive fracture toughness, two situations are divided at critical load. Wedge-splitting tests with ten temperatures varying from 20oC to 600oC are implemented. The complete load-crack opening displacement curves are obtained from which the initial and critical fracture toughness could be calculated experimentally. The validation of double-K fracture model to the post-fire concrete specimens is proved. Meanwhile the weight function method agrees well with the analytical method.
The synchronization of periodic routing messages

The paper considers a network with many apparently-independent periodic processes and discusses one method by which these processes can inadvertently become synchronized. In particular, we study the synchronization of periodic routing messages. We give examples of the harmful effect of these synchronized updates on other network traffic, and offer guidelines on how to avoid inadvertent synchronization. Using simulations and analysis, we study the process of synchronization and show that the transition from unsynchronized to synchronized traffic is not one of gradual degradation but is instead a very abrupt 'phase transition': in general, the addition of a single router will convert a completely unsynchronized traffic stream into a completely synchronized one. We show that synchronization can be avoided by the addition of randomization to the traffic sources and quantify how much randomization is necessary. In addition, we argue that the inadvertent synchronization of periodic processes is likely to become an increasing problem in computer networks.
Multicenter trial of hemodilution in acute ischemic stroke.

Hemodilution by the combination of venesection and dextran 40 administration has previously been reported to enhance neurologic recovery in the acute phase of ischemic stroke. To study this therapeutic principle in its "natural habitat," a stratified and randomized multicenter trial involving 15 large and small hospitals was performed. Patients with acute ischemic stroke of <48 hours' duration and with hematocrits of 38-50% on admission were randomized to a hemodilution (183 patients, mean age 72.0 years) or a control group (190 patients, mean age 71.6 years). The two groups did not differ in sex distribution or medical history. Hematocrit, blood pressure, and neurologic score were closely similar at entry. By graded venesection (250-1000 ml) during the first 2 days and dextran 40 infusions (500 ml daily) during 5 days, the mean hematocrit was reduced from 44.2 to 37.1%. Three-month survival expressed as life table product was 0.84 in hemodilution and 0.88 in control patients. In survivors, neurologic score and activities of daily living performance during 3 months of follow-up were not improved by hemodilution. Length of stay in an acute-care hospital and the need for long-term institutional care was not reduced among patients in the hemodilution group. Major cardiovascular events occurred somewhat more often and there was an apparent increase in mortality during the first few days of hemodilution therapy. However, the differences were not significant. We conclude that the present standardized treatment with moderate hemodilution has no overall beneficial effects in genera] patients with acute ischemic stroke. (Stroke 1987; 18:691-699)
Shaping ability of Ni-Ti rotary files in combination with GT rotary Ni-Ti file

Shaping of root canals is necessary to remove the microorganism and the pulp tissue and to facilitate obturation. The most appropriate canal shape for filling with gutta-percha and sealer is continuously tapering funnel shape with the smallest diameter at the end-point and the largest at orifice. Over the last 20 years or so many endodontic instruments have been developed and numerous preparation techniques have been introduced, but few has been shown to achieve consistently the required funnel shape. The inherent stiffness of stainless steel used in the manufacture of many endodontic instruments plays a part in the creation of aberration: this is further influenced by specific instrument design features and complexities in the canals. Shaping ability of Ni-Ti Rotary files in combination with GT Rotary Ni-Ti file
Towards Planning as Concurrency

We present a purely logical framework to planning where we bring the sequential and parallel composition in the plans to the same level, as in process algebras. The problem of expressing causality, which is very challenging for common logics and traditional deductive systems, is solved by resorting to a recently developed extension of multiplicative exponential linear logic with a self-dual, noncommutative operator. We present an encoding of the conjunctive planning problems in this logic, and provide a constructive soundness and completeness result. We argue that this work is the first, but crucial, step of a uniform deductive formalism that connects planning and concurrency inside a common language, and allows to transfer methods from concurrency to planning.