Miracle-dz/UniFAR-FTUs huggingface dataset:
Structural Fat Grafting: More Than a Permanent Filler

Summary: Grafted fat has many attributes of an ideal filler, but the results, like those of any procedure, are technique dependent. Fat grafting remains shrouded in the stigma of variable results experienced by most plastic surgeons when they first graft fat. However, many who originally reported failure eventually report success after altering their methods of harvesting, refinement, and placement. Many surgeons have refined their techniques to obtain long-term survival and volume replacement with grafted fat. They have observed that transplanted fat not only adjusts facial and body proportion but also improves surrounding tissues into which the fat is placed. They have noted not only the improvement in the quality of aging skin and scars but also a remarkable improvement in conditions such as radiation damage, chronic ulceration, breast capsular contracture, and damaged vocal cords. The mechanism of fat graft survival is not clear, and the role of adipose-derived stem cells and preadipocytes in fat survival remains to be determined. Early research has indicated the possible involvement of more undifferentiated cells in some of the observed effects of fat grafting on surrounding tissues. Of particular interest is the research that has pointed to the use of stem cells to repair and even to become bone, cartilage, muscle, blood vessels, nerves, and skin. Further studies are essential to understand grafted fat tissue.
Critiquing Human Resource Development's Dominant Masculine Rationality and Evaluating Its Impact

The purpose of this article is to critique human resource development's (HRD) dominant philosophy, practices, and research; illustrate how they negatively affect women HRD practitioners and recipients; and recommend alternative conceptualizations of the field. This article is grounded in a critical feminist theoretical framework, draws on critical theory and critical management studies, and is inspired by the author's ongoing disenchantment HRD's overreliance on “performative” ideas and practices.
The United Nations Global Compact Progress Reports as Management Control Instruments for Social Responsibility at Spanish Universities

Sustainability and social responsibility (SR) have emerged as a new way of managing all types of organizations. It is necessary that the resulting policy be integrated transversely in the control processes. The environment is especially demanding of higher education institutions (HEIs) and universities when it comes to behaving in a socially responsible manner due to their great influence in society. Many universities have adhered to the United Nations Global Compact (UNGC) principles to prove their commitment and gain legitimacy. The Communication on Progress (COP) is a management tool that helps to understand the level of implementation of the principles. Furthermore, COP analysis aids in establishing a process of continuous improvement in the management of the impacts that institutions have on their stakeholders. The aim of this study was to analyze the Spanish universities that have joined the Global Compact. Through a descriptive methodology, we identified the aspects that reflect this commitment and how this is integrated into their operational and educational processes. The results have shown that it is necessary to promote the integration of different international initiatives to guide the SR of universities. There are deficiencies in their SR management systems that prevent them from being more transparent, and it was found that in some cases, they are not aware of the implications the commitment can have in developed countries.
Coaching (and) commitment: linking ongoing professional development, quality teaching and student outcomes

This research conducted in primary schools in Northern Australia evaluated the effectiveness of the web‐based program ABRACADABRA (ABRA) as a tool to complement early childhood literacy instruction in an Australian and Indigenous context. A further component of this research was to monitor implementation fidelity. The ABRA training was built around professional development best practices to address the challenges of providing ongoing training in remote areas. Teachers attended a one‐day workshop that trained them in the use of ABRA, and continued learning was reinforced by pairing teachers with a literacy coach. Data were gathered through an implementation fidelity measure, researcher field notes, focus groups, teacher logbooks, and the Early Language and Literacy Classroom Observation tool. This paper outlines challenges and successes that the researcher/coaches experienced while supporting teachers.
Mutant strains of Chlamydomonas reinhardtii that move backwards only

Mutations at three independent loci in Chlamydomonas reinhardtii result in a striking alteration of cell motility. Mutant cells representing the three mbo loci move backwards only, propelled by a symmetrical "flagellar" type of bending pattern. The characteristic asymmetric "ciliary" type of flagellar bend pattern responsible for forward movement that predominates in wild-type cells is seldom seen in the mutants. This defect in motility was found to be a property of the mutant axonemes themselves: the isolated axonemes, reactivated by addition of ATP, showed exclusively the symmetrical wave form, and the protein composition of these axonemes differed from the wild-type composition. Axonemes obtained from mbo1 , mbo2 , and mbo3 cells were found to be deficient in six polypeptides regularly present in wild type. The mbo2 axonemes were deficient in two additional polypeptides. The polypeptides were identified in autoradiograms of two-dimensional SDS polyacrylamide gel electrophoretograms of 35S- or 32P-labeled axonemes. One of the six polypeptides has previously been identified; it is a component missing in a mutant deficient for inner dynein arms. Of the five axonemal polypeptides newly identified by the mbo mutants, four were shown to be present as phosphoproteins in wild-type axonemes. One of the additional polypeptides deficient in mbo2 axonemes was also shown to be phosphorylated in wild-type axonemes. Detailed ultrastructural analysis of the mbo1 flagella and the mbo1 , mbo2A , and mbo3 axonemes revealed that the mutants specifically lack the beak- like projections found within the B-tubules of outer doublets 5 and 6.
High Stakes? Considering Students with Mild Intellectual Disability in Accountability Systems.

Purdue University Abstract: The assessment participation of students with disabilities is now an important part of students' education and educational decision-making. While much attention has been paid to the participation of students with significant intellectual disability, little research exists regarding the extent to which students with mild intellectual disability participate in the accountability system. This study represented a secondary analysis of the National Longitudinal Transition Study-2 (NLTS2). The study focused on to what extent secondary students with mild intellectual disability participated in mandated assessments (i.e., does not participate, alternate assessment, general assessment with accommodations, and general assessment without accommoda- tions) as well as the relationship between participation and educational factors, such as special education curriculum, core classes in general education, and postschool goals. Participation in assessments by students with mild intellectual disability was multifaceted with the majority taking an alternate assessment. However, statistically significant relationships existed between assessment participation and special education curricu- lum, language arts and mathematics in general education, and postschool goals. Implications of the results are discussed in light of educational planning for students with mild intellectual disability.
Core Crimes and Transnational Business Corporations

International criminal law for long has been concerned with the conduct of individual natural persons, leaving aside the question of whether legal persons such as transnational business corporations also have obligations in respect of core crimes. While currently there is no international court or tribunal that can exercise criminal jurisdiction over private legal persons for core crimes, this does not mean that the prohibitions underlying these crimes are not binding on transnational business corporations. Post-World War II case law indicates that the obligations of such entities are not limited to crimes that have an economical dimension; depending on the circumstances of the case, business corporations may be involved in any core crime. However, the contextual elements of crimes against humanity and war crimes and the special intent required for the crime of genocide limit the scope of core crimes to extraordinary situations and generally will require the involvement of state or state-like actors. The possibility of liability for the crime of aggression is even more restricted; obligations arise only if transnational business corporations assume a leadership role.
TupleRank: Ranking Relational Databases using Random Walks on Extended K-partite Graphs

The significant increase in open access digital information has created incredible opportunities for modern database research, especially in exploiting significant computational resources to determine complex relationships within those data. In this paper, we consider the problem of analyzing relational databases and explaining relationships between entities in order to rank tuples based on a notion of relevance. For this purpose, we propose a solution of a class of link analysis algorithms known as the random walk, which can be deployed to discover interesting relationships amongst partial tuples of relational databases that would otherwise be hard to expose. We focus on a shortcoming of the absence of a special kind of relationship, which we call “returning relationship”. We demonstrate our ideas on the DBLP database, where we exploit structural variations on relationships between authors, conferences, topics, and co-authorships. We show how a distinction between normal relations and returning relations on objects within that database provides the basis for structuring a random walk algorithm to determine interesting relevance measures. We also show how structural changes in the organization of the random walk can produce novel results that are not attainable with previous database ranking methods.
Developing the Relevance of the Accounting Academy:The Importance of Drawing from the Diversity of Research Approaches

Purpose – One of the most important considerations in any research project is a compelling research question, the addressing of which will produce socially and/or economically relevant and beneficial insights based on high‐quality evidence. The purpose of this paper is to explain that each possible research question requires use of the particular research methods that will produce the high‐quality evidence relevant to that question, with the nature of the evidence and the methods required varying from research question to research question.Design/methodology/approach – This discussion paper explores and explains the role and function of interpretive accounting research advocates its adoption.Findings – As the research method needs to be suited to the research question, any restriction imposed on the credible research methods that are considered acceptable severely limits the ability of the accounting academy to serve the needs of society and the economy by addressing the broadest possible range of researc.
Rheumatoid arthritis and primary care: The case for early diagnosis and treatment

Abstract Rheumatoid arthritis is a chronic inflammatory disease that can cause severe pain and disability. Disease management historically was based on a "therapeutic pyramid" in which treatment escalated as symptoms worsened. However, the demonstration of early joint damage in patients with rheumatoid arthritis has emphasized the importance of early identification and treatment. Key features in establishing a diagnosis include joint examinations, assessments of extra-articular manifestations, laboratory tests, and radiologic examinations. Care must be taken to rule outother disorders with symptoms that overlap those of rheumatoid arthritis. Treatment of rheumatoid arthritis typically involves disease-modifying antirheumatic drugs, nonsteroidal anti-inflammatory drugs, and low-dose corticosteroids-often used in combination. A new class of therapeutic agents designed to neutralize inflammatory cytokines has added a new dimension to the therapeutic armamentarium against rheumatoid arthritis. Etanercept, a bioengineered soluble receptor fusion protein that blocks tumor necrosis factor activity, is the first compound in this class to be approved for treatment of patients with refractory rheumatoid arthritis. Therapeutic trials indicate that etanercept can reduce disease activity with relatively few drug-related adverse effects, thus helping persons with rheumatoid arthritis return to more normal, healthy lives.
High-dose methotrexate-based chemotherapy followed by consolidating radiotherapy in non-AIDS-related primary central nervous system lymphoma: European Organization for Research and Treatment of Cancer Lymphoma Group Phase II Trial 20962.

PURPOSE To confirm the feasibility and estimate the efficacy of methotrexate (MTX), teniposide, carmustine, and methylprednisolone (MBVP) chemotherapy combined with radiotherapy (RT) for patients with non-AIDS-related primary CNS lymphoma (PCNSL) treated in a multicenter setting. PATIENTS AND METHODS Treatment consisted of two cycles of MBVP (MTX 3 g/m2 days 1 and 15, teniposide 100 mg/m2 days 2 and 3, carmustine 100 mg/m2 day 4, methylprednisolone 60 mg/m2 days 1 to 5, and two intrathecal injections of MTX 15 mg, cytarabine 40 mg, and hydrocortisone 25 mg) followed by 40 Gy of RT. Primary end points were response and safety of this regimen. RESULTS Twelve centers included 52 patients who were all analyzed on an intent-to-treat basis. Median follow-up of all patients was 27 months. One patient progressed and died before treatment, and five patients died during treatment. Four patients received RT after one cycle of chemotherapy, and 42 patients completed the entire treatment. Hematologic grade 3 and 4 toxicity was seen in 78% of patients for leukocytes and 24% of patients for platelets. The overall response rate of all 52 patients was 81%. Two patients who did not fulfill the criteria of objective response survived more than 1 year; one of them is still alive without disease. Eighteen patients died; 11 deaths were a result of tumor, five were probably treatment-related, one was caused by late leukoencephalopathy, and one was a result of intercurrent disease. Median estimated overall survival was 46 months. CONCLUSION MBVP followed by RT for PCNSL has a high response rate. However, the 10% toxic death rate during treatment in a multicenter setting underlines the need for highly specialized care.
Developmental Cognitive Neuroscience Neural Mirroring Systems: Exploring the Eeg Mu Rhythm in Human Infancy

How do human children come to understand the actions of other people? What neural systems are associated with the processing of others' actions and how do these systems develop, starting in infancy? These questions span cognitive psychology and developmental cognitive neuroscience, and addressing them has important implications for the study of social cognition. A large amount of research has used behavioral measures to investigate infants' imitation of the actions of other people; a related but smaller literature has begun to use neurobiological measures to study infants' action representation. Here we focus on experiments employing electroencephalographic (EEG) techniques for assessing mu rhythm desynchronization in infancy, and analyze how this work illuminates the links between action perception and production prior to the onset of language. What are the main caveats and technical constraints for clarifying the nature of the neural overlap between action observation and execution in infancy?
Disruption of hippocampal synaptic transmission and long‐term potentiation by psychoactive synthetic cannabinoid ‘Spice’ compounds: comparison with Δ9‐tetrahydrocannabinol

There has been a marked increase in the availability of synthetic drugs designed to mimic the effects of marijuana. These cannabimimetic drugs, sold illicitly as ‘Spice’ and related products, are associated with serious medical complications in some users. In vitro studies suggest that synthetic cannabinoids in these preparations are potent agonists at central cannabinoid CB1 receptors (CB1Rs), but few investigations have delineated their cellular effects, particularly in comparison with the psychoactive component of marijuana, Δ9‐tetrahydrocannabinol (Δ9‐THC). We compared the ability of three widely abused synthetic cannabinoids and Δ9‐THC to alter glutamate release and long‐term potentiation in the mouse hippocampus. JWH‐018 was the most potent inhibitor of hippocampal synaptic transmission (EC50 ~15 nM), whereas its fluoropentyl derivative, AM2201, inhibited synaptic transmission with slightly lower potency (EC50 ~60 nM). The newer synthetic cannabinoid, XLR‐11, displayed much lower potency (EC50 ~900 nM) that was similar to Δ9‐THC (EC50 ~700 nM). The effects of all compounds occurred via activation of CB1Rs, as demonstrated by reversal with the selective antagonist/inverse agonist AM251 or the neutral CB1R antagonist PIMSR1. Moreover, AM2201 was without effect in the hippocampus of transgenic mice lacking the CB1R. Hippocampal slices exposed to either synthetic cannabinoids or Δ9‐THC exhibited significantly impaired long‐term potentiation (LTP). We find that, compared with Δ9‐THC, the first‐generation cannabinoids found in Spice preparations display higher potency, whereas a recent synthetic cannabinoid is roughly equipotent with Δ9‐THC. The disruption of synaptic function by these synthetic cannabinoids is likely to lead to profound impairments in cognitive and behavioral function.
Chronic cocaine use as a neuropsychiatric syndrome: A model for debate

In humans, chronic cocaine abuse is associated with changes in the central nervous system (CNS). Neuropathological changes include cerebrovascular events, EEG abnormalities, vasculitis, seizures, and decrements in neurobehavioral performance. The acute administration of cocaine is associated with acute psychotic episodes and paranoid states while withdrawal from the drug is often associated with depressed mood. The mechanistic basis of these behavioral states is not known. Given the structural and functional changes associated with cocaine use, we propose that the chronic heavy use of cocaine may result in a neuropsychiatric syndrome which might be associated with neuropsychological changes that are not obvious during routine clinical evaluation of drug‐using individuals. This disconnection syndrome, because of its sublety, might have deleterious effects on both acute and long‐term therapeutic interventions with these subjects. An approach which deals with cocaine abuse as a neuropsychiatric disorder might be more beneficial to the long‐term goal of treating these patients. This approach entails a neurobehavioral evaluation which will be comprised of a thorough neurological and psychiatric examination, neuropsychological testing, and imaging studies. The results of this evaluation would provide a more rational basis for cognitive and/or pharmacological therapies. (The article is a US Government work and, as such, is in the public domain in the United States of America.) © 1996 Wiley‐Liss, Inc.
Music Education and the Brain

Neuroscientists have worked for over two decades to understand how the brain processes music, affects emotions, and changes brain development. Much of this research has been based on a model that compares the brain function of participants classified as musicians and nonmusicians. This body of knowledge reveals a large number of benefits from music education including improvements in memory, language acquisition, executive function, and brain plasticity. These findings offer the beginnings of an evidence-based argument in favor of music education for every child. Yet if the potential of this research is to be leveraged for this purpose, music educators need to know the type, period, and age range for music education that has been shown to affect positive, measurable, and enduring change in brain development. This article explores the criteria used to define musician and suggests ways these criteria could be used to advocate for specific developments in music education curricula.
Cohesion and enmeshment revisited : Differentiation, identity, and well-being in two european cultures

We examined the nature and implications of family differentiation among adolescents facing a life transition in 2 European countries with differing family cultures. One hundred and twenty-four Italian and 109 U.K. adolescents completed measures of family differentiation (cohesion and enmeshment), identity threat (perception of threat to the self associated with finishing school), life satisfaction, depressive symptoms, and anxiety. Confirmatory factor analyses showed that cohesion and enmeshment were distinguishable in both countries, orthogonal in the U.K. but positively correlated in Italy. Family cohesion was associated with better psychological well-being in both countries; enmeshment was associated with poorer psychological well-being in the U.K. but not in Italy. Structural equation models showed that effects on well-being were fully mediated by identity threat in both cultures.
Housing Quality and Children’s Socioemotional Health

An observer-based, standardized index of housing quality (structural quality, privacy, indoor climate, hazards, cleanliness/clutter, and children’s resources) is significantly related to psychological distress and a behavioral index of learned helplessness, which reflects an important component of human motivation. Independent of household income, third-through fifth-grade children residing in poorer quality housing have more psychological symptoms and less task persistence than their counterparts living in better quality housing.
Distributed wireless control for building energy management?

Automated building energy management systems are essential to enabling the development of mass-market, low-energy buildings. In existing and future buildings, the impacts of occupant behaviors contribute significantly to the total energy efficiency. As building technologies and materials improve, the relative impact of behavioral factors is more significant. We propose a general framework where building systems can share information in order to optimize performance. To be successful, such a system must be responsive, intuitive, robust, and scalable. As a first step toward achieving these goals, we present a prototype distributed control system for building energy management that uses wireless sensor network-class nodes. Using protocol independent multicast, sensors and controllers are allowed to efficiently share information in a distributed peer-to-peer fashion. Our prototype system achieved an energy savings of 7.1% - 14.6% by implementing a relatively simple control policy. Based on the results of this this work we have identified three key areas for future work.