Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-range interactions of hydrogen atoms in excited states. II. Hyperfine-resolved 2S-2S systems

The interaction of two excited hydrogen atoms in metastable states constitutes a theoretically interesting problem because of the quasi-degenerate 2P_{1/2} levels which are removed from the 2S states only by the Lamb shift. The total Hamiltonian of the system is composed of the van der Waals Hamiltonian, the Lamb shift and the hyperfine effects. The van der Waals shift becomes commensurate with the 2S-2P_{3/2} fine-structure splitting only for close approach (R < 100 a_0, where a_0 is the Bohr radius) and one may thus restrict the discussion to the levels with n=2 and J=1/2 to good approximation. Because each S or P state splits into an F=1 triplet and an F=0 hyperfine singlet (eight states for each atom), the Hamiltonian matrix {\em a priori} is of dimension 64. A careful analysis of symmetries the problem allows one to reduce the dimensionality of the most involved irreducible submatrix to 12. We determine the Hamiltonian matrices and the leading-order van der Waals shifts for states which are degenerate under the action of the unperturbed Hamiltonian (Lamb shift plus hyperfine structure). The leading first- and second-order van der Waals shifts lead to interaction energies proportional to 1/R^3 and 1/R^6 and are evaluated within the hyperfine manifolds. When both atoms are metastable 2S states, we find an interaction energy of order E_h chi (a_0/R)^6, where E_h and L are the Hartree and Lamb shift energies, respectively, and chi = E_h/L ~ 6.22 \times 10^6 is their ratio.
Terminal field volume of the glossopharyngeal nerve in adult rats reverts to prepruning size following microglia depletion with PLX5622

Programmed reduction of synapses is a hallmark of the developing brain, with sensory systems emerging as useful models with which to study this pruning. The central projections (terminal field) of the gustatory glossopharyngeal nerve (GL) of the rat are a prime example of developmental pruning, undergoing an approximate 66% reduction in volume from postnatal day 15 (P15) to P25. Later in adulthood, developmental GL pruning can be experimentally reversed, expanding to preweaning volumes, suggesting mature volumes may be actively maintained throughout the life span. Microglia are central nervous system glia cells that perform pruning and maintenance functions in other sensory systems, including other gustatory nerves. To determine their role in GL pruning, we depleted microglia from Sprague–Dawley rat brains from P1 to P40 using daily intraperitoneal injections of the colony‐stimulating factor 1 receptor inhibitor PLX5622. This prevented GL developmental pruning, resulting in preweaning terminal field volumes and innervation patterns persisting through P40, 2 weeks after pruning is normally completed. These findings show microglia are necessary for developmental GL pruning. Ceasing PLX5622 treatments at P40 allowed microglia repopulation, and within 4 weeks the GL terminal field had reduced to control volumes, indicating that pruning can occur outside of the typical developmental period. Conversely, when microglia were depleted in adult rats, GL terminal fields expanded, reverting to sizes comparable to the neonatal rat. These data indicate that microglia are required for GL pruning and may continue to maintain the GL terminal field at a reduced size into adulthood.
Comprehensive and reliable sonographic assessment and scoring system for inflammatory lesions of the paediatric ankle

Abstract Objective The clinical decision-making process in paediatric arthritis lacks an objective, reliable bedside imaging tool. The aim of this study was to develop a US scanning protocol and assess the reliability of B-mode and Doppler scoring systems for inflammatory lesions of the paediatric ankle. Methods As part of the Childhood Arthritis and Rheumatology Research Alliance (CARRA) US group, 19 paediatric rheumatologists through a comprehensive literature review developed a set of standardized views and scoring systems to assess inflammatory lesions of the synovial recesses as well as tendons of the paediatric ankle. Three rounds of scoring of still images were followed by one practical exercise. Agreement among raters was assessed using two-way single score intraclass correlation coefficients (ICC). Results Of the 37 initially identified views to assess the presence of ankle synovitis and tenosynovitis, nine views were chosen for each B-mode and Doppler mode semi-quantitative evaluation. Several scoring exercises and iterative modifications resulted in a final highly reliable scoring system: anterior tibiotalar joint ICC: 0.93 (95% CI 0.92, 0.94), talonavicular joint ICC: 0.86 (95% CI 0.81, 0.90), subtalar joint ICC: 0.91 (95% CI 0.88, 0.93) and tendons ICC: 0.96 (95% CI 0.95, 0.97). Conclusion A comprehensive and reliable paediatric ankle US scanning protocol and scoring system for the assessment of synovitis and tenosynovitis were successfully developed. Further validation of this scoring system may allow its use as an outcome measure for both clinical and research applications.
Parametric Decay Instability and Dissipation of Low-frequency Alfvén Waves in Low-beta Turbulent Plasmas

Evolution of the parametric decay instability (PDI) of a circularly polarized Alfvén wave in a turbulent low-beta plasma background is investigated using 3D hybrid simulations. It is shown that the turbulence reduces the growth rate of PDI as compared to the linear theory predictions, but PDI can still exist. Interestingly, the damping rate of the ion acoustic mode (as the product of PDI) is also reduced as compared to the linear Vlasov predictions. Nonetheless, significant heating of ions in the direction parallel to the background magnetic field is observed due to resonant Landau damping of the ion acoustic waves. In low-beta turbulent plasmas, PDI can provide an important channel for energy dissipation of low-frequency Alfvén waves at a scale much larger than the ion kinetic scales, different from the traditional turbulence dissipation models.
An in-silico insight into the predictive interaction of Apolipoprotein-E with Epstein-Barr virus proteins and their probable role in mediating Alzheimer’s disease

Abstract Recent reports suggest that persistent Epstein-Barr virus (EBV) infection and its recurrent reactivation could instigate the formation of proteinaceous plaques in the brain: a hallmark of Alzheimer’s disease (AD). Interestingly, a major genetic risk factor of AD, the apolipoprotein E (ApoE), could also influence the outcome of EBV infection in an individual. The ApoE is believed to influence the proteinaceous plaque clearance from the brain, and its defective functioning could result in the aggregate deposition. The persistent presence of EBV infection in a genetically predisposed individual could create a perfect recipe for severe neurodegenerative consequences. Therefore, in the present study, we investigated the possible interactions between ApoE and various EBV proteins using computational tools. Our results showed possibly stable de-novo interactions between the C-terminal domain of ApoE3 and EBV proteins: EBV nuclear antigen-1 (EBNA1) and BamHI Z fragment leftward open reading frame-1 (BZLF1). The EBNA1 protein of EBV plays a crucial role in establishing latency and replication of the virus. Whereas BZLF1 is involved in the lytic replication cycle. The proposed interaction of EBV proteins at the ligand-binding site of ApoE3 on CTD could interfere with- its capability to sequester amyloid fragments and, hence their clearance from the brain giving rise to AD pathology. This study provides a new outlook on EBV’s underexplored role in AD development and paves the way for novel avenues of investigation which could further our understanding of AD pathogenesis. Communicated by Ramaswamy H. Sarma
Perceived risk, emotions, and stress in response to COVID‐19: The interplay of media use and partisanship

Relationships between risk perceptions, emotions, and stress are well‐documented, as are interconnections between stress, emotion, and media use. During the early COVID‐19 pandemic, the public responded psychologically to the threat posed by the pandemic, and frequently utilized media for information and entertainment. However, we lack a comprehensive picture of how perceived risk, emotion, stress, and media affected each other longitudinally during this time. Further, although response to the pandemic was highly politicized, research has yet to address how partisan affiliation moderated relationships between risk, emotion, stress, and media use over time. This three‐wave (N = 1021) panel study assessed the interplay of risk, emotion, stress, and media use for Americans with different political affiliations between March and May of 2020. Findings indicate that perceived risk, emotion, and stress at Time 1 predicted media use at Time 2, with predictors varying by type of media. Use of entertainment media and social/mobile media predicted later stress (Time 3), but news consumption did not. Later risk perceptions (Time 3) were not influenced by media use at Time 2. The predictors and consequences of different types of media use were notably different for Republicans and Democrats. In particular, risk perceptions predicted greater news use among Democrats but greater entertainment media use among Republicans. Moreover, social/mobile media use resulted in perceiving the risks of COVID‐19 as less serious for Republicans while increasing stress over time for Democrats.
Hostile media perceptions and consumption of genetically modified and organic foods: Examining the mediating role of risk‐benefit assessments

Drawing upon the hostile media effect, this study examined how perceived media bias in covering genetically modified (GM) food influences individuals’ risk–benefit assessments of it and their food consumption behaviors. The results of a nationally representative survey (N = 1364) showed that individuals seeing media coverage as more biased in favor of GM food perceived it as more hazardous, which was related to a higher proportion of organic food consumption in their diets. In contrast, perceived media coverage as less slanted toward GM food was associated with more benefit perceptions of it, thereby predicting its higher proportion in individuals’ diets. More importantly, the indirect effect of perceived media bias on GM food consumption through benefit perceptions was more pronounced among males than females. The findings of this study not only provide empirical evidence of the perceptual and behavioral outcomes of hostile media perceptions, but also offer valuable insights for journalists and education practitioners to improve public understanding of emerging food technologies.
Autosomal recessive LRP1-related syndrome featuring cardiopulmonary dysfunction, bone dysmorphology, and corneal clouding

We provide the first study of two siblings with a novel autosomal recessive LRP1-related syndrome identified by rapid genome sequencing and overlapping multiple genetic models. The patients presented with respiratory distress, congenital heart defects, hypotonia, dysmorphology, and unique findings, including corneal clouding and ascites. Both siblings had compound heterozygous damaging variants, c.11420G > C (p.Cys3807Ser) and c.12407T > G (p.Val4136Gly) in LRP1, in which segregation analysis helped dismiss additional variants of interest. LRP1 analysis using multiple human/mouse data sets reveals a correlation to patient phenotypes of Peters plus syndrome with additional severe cardiomyopathy and blood vessel development complications linked to neural crest cells.
Do medical students with a disability experience adverse educational outcomes on UK medical courses?

Abstract Background International data demonstrate that medical students with disabilities experience differential awarding. One cross-sectional study finds lower graduation rates and scores in written exams, with no impact on clinical exams. Disabled students graduated with lower decile scores. This quantitative, retrospective, longitudinal study explored the impact of disability on exam performance, course performance and course discontinuation. Method Anonymised data were obtained for 1743 students on a UK graduate medical programme from 2011 to present. Statistical tests, including t-tests and one-way ANOVA were conducted for main effects of demographic variables on exam results and categorical outcomes. Regression models established the effects of variables and sub-categories of variables on results and categorical outcomes. Results Significant main effects of disability on exam scores were identified, as well as failure probability. Regressions showed significant differences in outcomes between different types of disability, with mental health conditions predicting course discontinuation. A significant amplifying effect was found for BAME students with disability. Conclusion Disability had a significant negative impact on all course outcomes, illustrating inequity in medical training and an area of focus for curriculum development. Intersectional data identified a key disadvantaged subgroup of medical students.
Detection of cancerous biological tissue areas by means of infrared absorption and SERS spectroscopy of intercellular fluid

We present a novel approach to the detection of cancerous kidney tissue areas by measuring vibrational spectra (IR absorption or SERS) of intercellular fluid taken from the tissue. The method is based on spectral analysis of cancerous and normal tissue areas in order to find specific spectral markers. The samples were prepared by sliding the kidney tissue over a substrate - surface of diamond ATR crystal in case of IR absorption or calcium fluoride optical window in case of SERS. For producing the SERS signal the dried fluid film was covered by silver nanoparticle colloidal solution. In order to suppress fluorescence background the measurements were performed in the NIR spectral region with the excitation wavelength of 1064 nm. The most significant spectral differences – spectral markers - were found in the region between 400 and 1800 cm-1, where spectral bands related to various vibrations of fatty acids, glycolipids and carbohydrates are located. Spectral markers in the IR and SERS spectra are different and the methods can complement each other. Both of them have potential to be used directly during surgery. Additionally, IR absorption spectroscopy in ATR mode can be combined with waveguide probe what makes this method usable in vivo.
Holistic Wellness Coaching for Older Adults: Preliminary Evidence for a Novel Wellness Intervention in Senior Living Communities

Although resident wellness is increasingly a priority in senior living communities, there are few programs that promote holistic wellness in later life. A total of 79 residents (ages 71 to 97; M = 84.27, SD = 6.46) from eight senior living communities completed a pilot study of a novel, staff-led wellness coaching program consisting of resident-driven goals and individual and group coaching sessions. Participants completed surveys at three time points (pre-program, post-program, and 1-month follow-up). Repeated measures ANOVAs revealed positive changes in resident health satisfaction, physical quality of life (QOL), psychological QOL, loneliness, relatedness, competence, and sense of purpose. Some of these results (i.e., psychological QOL, loneliness) persisted at follow-up. Residents reported high satisfaction with the program. These findings have implications for the application of holistic wellness frameworks in later life, as well as the development and implementation of wellness coaching programs with older adults.
Measurement of Magnetic Field Fluctuations and Plasma Rotation Speed

An experimental investigation of effects of external resonant helical field on poloidal and radial components of magnetic field fluctuations, plasma rotation speed and plasma current in IR-T1 tokamak was presented. Eight Mirnov coils in poloidal direction and four Mirnov coils in radial direction were installed on outer surface of the IR-T1 tokamak chamber to measure poloidal and radial components of external magnetic field fluctuations. Also we inserted a Mach probe with four tips 5mm inside the IR-T1 tokamak chamber to measure plasma rotation speed. In case of absence of RHF, poloidal and radial components of external magnetic field fluctuations were measured. On the other hand, the external RHF applied to tokamak plasma and again the magnetic field fluctuations were measured. Measurement results with and without RHF (L=2, L=3, L=2 & 3) show that the addition of a relatively small amount of RHF could be effective for improving the quality of tokamak plasma discharge by flatting the plasma current and decreasing the magnetic field fluctuations.
A Socio-Technical Approach to Cyber-Risk Assessment

 Abstract — Evaluating the levels of cyber-security risks within an enterprise is most important in protecting its information system, services and all its digital assets against security incidents (e.g. accidents, malicious acts, massive cyber-attacks). The existing risk assessment methodologies (e.g. eBIOS, OCTAVE, CRAMM, NIST-800) adopt a technical approach considering as attack factors only the capability, intention and target of the attacker, and not paying attention to the attacker’s psychological profile and personality traits. In this paper, a socio-technical approach is proposed in cyber risk assessment, in order to achieve more realistic risk estimates by considering the personality traits of the attackers. In particular, based upon principles from investigative psychology and behavioural science, a multi-dimensional, extended, quantifiable model for an attacker’s profile is developed, which becomes an additional factor in the cyber risk level calculation.
MetamorphX: An Ungrounded 3-DoF Moment Display that Changes its Physical Properties through Rotational Impedance Control

Humans can estimate the properties of wielded objects (e.g., inertia and viscosity) using the force applied to the hand. We focused on this mechanism and aimed to represent the properties of wielded objects by dynamically changing the force applied to the hand. We propose MetamorphX, which uses control moment gyroscopes (CMGs) to generate ungrounded, 3-degrees of freedom moment feedback. The high-response moments obtained CMGs allow the inertia and viscosity of motion to be set to the desired values via impedance control. A technical evaluation indicated that our device can generate a moment with a 60-ms delay. The inertia and viscosity of motion were varied by 0.01 kgm2 and 0.1 Ns, respectively. Additionally, we demonstrated that our device can dynamically change the inertia and viscosity of motion through virtual reality applications.
AUIT – the Adaptive User Interfaces Toolkit for Designing XR Applications

Adaptive user interfaces can improve experiences in Extended Reality (XR) applications by adapting interface elements according to the user’s context. Although extensive work explores different adaptation policies, XR creators often struggle with their implementation, which involves laborious manual scripting. The few available tools are underdeveloped for realistic XR settings where it is often necessary to consider conflicting aspects that affect an adaptation. We fill this gap by presenting AUIT, a toolkit that facilitates the design of optimization-based adaptation policies. AUIT allows creators to flexibly combine policies that address common objectives in XR applications, such as element reachability, visibility, and consistency. Instead of using rules or scripts, specifying adaptation policies via adaptation objectives simplifies the design process and enables creative exploration of adaptations. After creators decide which adaptation objectives to use, a multi-objective solver finds appropriate adaptations in real-time. A study showed that AUIT allowed creators of XR applications to quickly and easily create high-quality adaptations.
Hands-On: Using Gestures to Control Descriptions of a Virtual Environment for People with Visual Impairments

Virtual reality (VR) uses three main senses to relay information: sight, sound, and touch. People with visual impairments (PVI) rely primarily on auditory and haptic feedback to receive information in VR. While researchers have explored several approaches to make navigation and perception of objects more accessible in VR, none of them offer a natural way to request descriptions of objects, nor control of the flow of auditory information. In this demonstration, we present a haptic glove that PVI can use to request object descriptions in VR with their hands through familiar hand gestures. We contribute designs for a set of hand gestures that allow PVI to interactively get descriptions of the VR environment. We plan to conduct an user study where we will have PVI interact with a VR environment using these gestures to request audio descriptions.
Lightweight Feature De-redundancy and Self-calibration Network for Efficient Image Super-resolution

In recent years, thanks to the inherent powerful feature representation and learning abilities of the convolutional neural network (CNN), deep CNN-steered single image super-resolution approaches have achieved remarkable performance improvements. However, these methods are often accompanied by large consumption of computing and memory resources, which is difficult to be adopted in real-world application scenes. To handle this issue, we design an efficient Feature De-redundancy and Self-calibration Super-resolution network (FDSCSR). In particular, a Feature De-redundancy and Self-calibration Block (FDSCB) is proposed to reduce the repetitive feature information extracted by the model and further enhance the efficiency of the model. Then, based on FDSCB, a Local Feature Fusion Module is presented to elaborately utilize and fuse the feature information extracted by each FDSCB. Abundant experiments on benchmarks have demonstrated that our FDSCSR achieves superior performance with relatively less computational consumption and storage resource than other state-of-the-art approaches. The code is available at https://github.com/IVIPLab/FDSCSR.
OmniScribe: Authoring Immersive Audio Descriptions for 360° Videos

Blind people typically access videos via audio descriptions (AD) crafted by sighted describers who comprehend, select, and describe crucial visual content in the videos. 360° video is an emerging storytelling medium that enables immersive experiences that people may not possibly reach in everyday life. However, the omnidirectional nature of 360° videos makes it challenging for describers to perceive the holistic visual content and interpret spatial information that is essential to create immersive ADs for blind people. Through a formative study with a professional describer, we identified key challenges in describing 360° videos and iteratively designed OmniScribe, a system that supports the authoring of immersive ADs for 360° videos. OmniScribe uses AI-generated content-awareness overlays for describers to better grasp 360° video content. Furthermore, OmniScribe enables describers to author spatial AD and immersive labels for blind users to consume the videos immersively with our mobile prototype. In a study with 11 professional and novice describers, we demonstrated the value of OmniScribe in the authoring workflow; and a study with 8 blind participants revealed the promise of immersive AD over standard AD for 360° videos. Finally, we discuss the implications of promoting 360° video accessibility.