Miracle-dz/UniFAR-FTUs huggingface dataset:
Extracting View oint s from Liane

Viewpoints are coherent collections of facts that describe a concept from a particular perspective. They are essential for a wide variety of tasks, such as explanation generation and qualitative modeling. We have identified many types of viewpoints and developed a program, the View Retriever, for extracting them from knowledge bases, either singly or in combinations. The View Retriever provides a general solution to the central problem in extracting viewpoints: determining which facts are relevant to requested viewpoints. Our evaluation indicates that viewpoints extracted by the View Retriever are comparable in coherence to those people construct.
Direct Interaction of Rnd1 with Plexin-B1 Regulates PDZ-RhoGEF-mediated Rho Activation by Plexin-B1 and Induces Cell Contraction in COS-7 Cells*

Plexins are receptors for the axon guidance molecule semaphorins, and several lines of evidence suggest that Rho family small GTPases are implicated in the downstream signaling of Plexins. Recent studies have demonstrated that Plexin-B1 activates RhoA and induces growth cone collapse through Rho-specific guanine nucleotide exchange factor PDZ-RhoGEF. Here we show that Rnd1, a member of Rho family GTPases, directly interacted with the cytoplasmic domain of Plexin-B1. In COS-7 cells, coexpression of Rnd1 and Plexin-B1 induced cell contraction in response to semaphorin 4D (Sema4D), a ligand for Plexin-B1, whereas expression of Plexin-B1 alone or coexpression of Rnd1 and a Rnd1 interaction-defective mutant of Plexin-B1 did not. The Sema4D-induced contraction in Plexin-B1/Rnd1-expressing COS-7 cells was suppressed by dominant negative RhoA, a Rho-associated kinase inhibitor, a dominant negative form of PDZ-RhoGEF, or deletion of the carboxyl-terminal PDZ-RhoGEF-binding region of Plexin-B1, indicating that the PDZ-RhoGEF/RhoA/Rho-associated kinase pathway is involved in this morphological effect. We also found that Rnd1 promoted the interaction between Plexin-B1 and PDZ-RhoGEF and thereby dramatically potentiated the Plexin-B1-mediated RhoA activation. We propose that Rnd1 plays an important role in the regulation of Plexin-B1 signaling, leading to Rho activation during axon guidance and cell migration.
Latency-Aware Dynamic Voltage and Frequency Scaling on Many-Core Architectures for Data-Intensive Applications

Low power is the first-class design requirement for HPC systems. Dynamic voltage and frequency scaling (DVFS) has become the commonly used and efficient technology to achieve a trade-off between power consumption and system performance. However, most the prior work using DVFS did not take into account the latency of voltage/frequency scaling, which is a critical factor in real hardware determining the power efficiency of the power management algorithm. This paper, firstly, investigate the latency features of DVFS on a real many-core hardware platform. Secondly, we propose a latency-aware DVFS algorithm for profile-based power management to avoid aggressive power state transitions. At last, we evaluate our algorithm on Intel SCC platform using a data-intensive benchmark, Graph 500 benchmark. The experimental results not only show impressive potential for energy saving in data-intensive applications (up to 31% energy saving and 60% EDP reduction), but also evaluate the efficiency of our latency-aware DVFS algorithm which achieves 12.0% extra energy saving and 5.0% extra EDP reduction, moreover, increases the execution performance by 22.4%.
In Vivo Real-Time Imaging of Exogenous HGF-Triggered Cell Migration in Rat Intact Soleus Muscles

The transplantation of myogenic cells is a potentially effective therapy for muscular dystrophy. However, this therapy has achieved little success because the diffusion of transplanted myogenic cells is limited. Hepatocyte growth factor (HGF) is one of the primary triggers to induce myogenic cell migration in vitro. However, to our knowledge, whether exogenous HGF can trigger the migration of myogenic cells (i.e. satellite cells) in intact skeletal muscles in vivo has not been reported. We previously reported a novel in vivo real-time imaging method in rat skeletal muscles. Therefore, the present study examined the relationship between exogenous HGF treatment and cell migration in rat intact soleus muscles using this imaging method. As a result, it was indicated that the cell migration velocity was enhanced in response to increasing exogenous HGF concentration in skeletal muscles. Furthermore, the expression of MyoD was induced in satellite cells in response to HGF treatment. We first demonstrated in vivo real-time imaging of cell migration triggered by exogenous HGF in intact soleus muscles. The experimental method used in the present study will be a useful tool to understand further the regulatory mechanism of HGF-induced satellite cell migration in skeletal muscles in vivo.
Questioning the Rhetoric of Social Mix: Courteous Community or Hidden Hostility?

This paper explores the increasingly important role of ‘social mix’ in the management practices of the NSW Department of Housing. Social mix is a policy response to the many perceived social, cultural and economic problems related to the concentration of public tenants within larger housing estates. Social mix involves the integration and assimilation of public housing tenants into areas dominated by private home ownership and private rental. Such policies are based upon the belief that social mix has the ability to alter many of these problems simply through the presence of a ‘community’. However, this paper questions the normative construction of homeowners as possessing a ‘community’ which, by implication, will be passed on to public tenants. Through an in-depth case-study, it is shown that ‘community’, as constructed by social mix policy rhetoric, may in fact further disadvantage public tenants through processes of othering, stigmatisation and oppression, which operate outside these traditional understandings of community. In addition, this research shows that, rather than increased community integration, it is the physical function of neighbourhood and its direct role in service provision which is the most advantageous constituent of social mix for public housing tenants.
Multi-scale modeling of gene regulatory networks via integration of temporal and topological biological data

Regulome is the dynamic network representation of the regulatory interplay among genes, proteins and other cellular components that control cellular processes. Reconstruction of gene regulatory networks (GRN) delineates one of the main objectives of Systems Biology towards understanding the organization of regulome. Significant progress has been reported the last years regarding GRN reconstruction methods, but the majority of them either consider information originating solely from gene expression data or/and are applied on a small fraction of the experimental dataset. In this paper, we will describe an integrative method, utilizing both temporal information arriving from time-series gene expression profiles, as well as topological properties of protein networks. The proposed methodology detects relations among either groups of genes or specific genes depending on the level of abstraction or resolution requested. Application on real data proved the ability of the method to extract relations in accordance with current biological knowledge as well as discriminate between different experimental conditions.
Physiological gait controls with a neural pattern generator

This paper proposes a control methodology for human gait with a pattern generator. The pattern generator generates cyclic signals via a couple of mutually inhibited neurons, and drives a proportional derivative controller that supplies joint angles of a virtual human. The state of the pattern generator is entrained by the signal of the controller, and such mutual feedback stabilizes the generation of rhythmic signals for variable conditions. Legs and arms can automatically synchronize their periodical movements without using a central supervisor because the corresponding neural oscillators mutually feed their output signals. Our system generates various gaits in a common mechanism with a small number of parameters, which is well suited for real-time, interactive and on-the-fly controls. Moreover, the movements obtained from motion capture data can be controlled by introducing adjustable non-linear filters. Copyright © 2002 John Wiley & Sons, Ltd.
Diminished S-Phase Cyclin-Dependent Kinase Function Elicits Vital Rad53-Dependent Checkpoint Responses in Saccharomyces cerevisiae

ABSTRACT Cyclin-dependent kinase (CDK) is required for the initiation of chromosomal DNA replication in eukaryotes. In Saccharomyces cerevisiae, the Clb5 and Clb6 cyclins activate Cdk1 and drive replication origin firing. Deletion of CLB5 reduces initiation of DNA synthesis from late-firing origins. We have examined whether checkpoints are activated by loss of Clb5 function and whether checkpoints are responsible for the DNA replication defects associated with loss of Clb5 function. We present evidence for activation of Rad53 and Ddc2 functions with characteristics suggesting the presence of DNA damage. Deficient late origin firing in clb5Δ cells is not due to checkpoint regulation, but instead, directly reflects the decreased abundance of S-phase CDK, as Clb6 activates late origins when its dosage is increased. Moreover, the viability of clb5Δ cells depends on Rad53. Activation of Rad53 by either Mrc1 or Rad9 contributes to the survival of clb5Δ cells, suggesting that both DNA replication and damage pathways are responsive to the decreased origin usage. These results suggest that reduced origin usage leads to stress or DNA damage at replication forks, necessitating the function of Rad53 in fork stabilization. Consistent with the notion that decreased S-CDK function creates stress at replication forks, deletion of RRM3 helicase, which facilitates replisome progression, greatly diminished the growth of clb5Δ cells. Together, our findings indicate that deregulation of S-CDK function has the potential to exacerbate genomic instability by reducing replication origin usage.
Effect of MCI-196 on serum phosphate and cholesterol levels in haemodialysis patients with hyperphosphataemia: a double-blind, randomized, placebo-controlled study.

BACKGROUND Hyperphosphataemia in patients on haemodialysis (HD) can lead to, or worsen, secondary hyperparathyroidism (with associated bone disease) and extra-skeletal calcifications associated with increased cardiovascular morbidity and mortality. MCI-196 is a new, non-absorbed, non-calcium-based phosphate binder. The aim of this study was to determine the effect of three fixed doses of MCI-196, on serum phosphorus level and other parameters relevant to HD patients. METHODS A total of 120 chronic kidney disease (CKD) stage 5 patients on HD and with the serum phosphorus level >2.1 mmol/l were randomized to receive double-blind treatment with either 3, 6 and 9 g/day MCI-196 or placebo for 3 weeks. RESULTS Serum phosphorous decreased in all three treatment groups (-0.038, -0.268 and -0.257 mmol/l in the 3, 6 and 9 g/day groups, respectively). The difference between treatment and placebo groups was significant for the 6 and 9 g/day groups (P < 0.05 in both cases). Changes in the mean serum calcium were minimal and without relevant differences between groups. However, calcium-phosphorus product (Ca x P) was significantly reduced in the 6 and 9 g/day groups P < 0.05). MCI-196 at all doses decreased serum intact PTH between baseline and endpoint, and differences between treatment groups and placebo were statistically significant for the 3 and 9 g/day groups (P < 0.02 in both cases). Both serum total and LDL cholesterol decreased significantly in all treatment groups compared to placebo (by 0.71-1.05 mmol/l, for total cholesterol and 0.68-0.94 mmol/l for LDL cholesterol P < 0.001 in all cases). There was minimal change in serum HDL cholesterol. MCI-196 at all doses decreased significantly serum uric acid between baseline and endpoint compared to placebo (P < 0.005 in all cases). The drug was well tolerated. CONCLUSION MCI-196 significantly reduced serum phosphorus, Ca x P and PTH, without effecting serum calcium levels. The additional reduction in total cholesterol and LDL cholesterol indicates a possible dual mechanism of action of MCI-196 that has the potential to reduce cardiovascular morbidity in CKD stage 5 patients.
Single-Resonator Dual-Frequency Thin-Film Piezoelectric-on-Substrate Oscillator

This paper reports on the design and implementation of a sub-milliwatt dual-frequency oscillator that utilizes two high-Q acoustic modes of an AIN-on-Si microresonator. While operating in atmospheric pressure, the microresonator shows Qunloaded of 7100 at 35.5 MHz, and 4000 at 105.7 MHz corresponding to the first- and the third-order width-extensional resonance modes. The measured Qunloaded is improved to 10100 in vacuum for the first-order resonance mode. The phase-noise of a two-transistor oscillator circuit using this resonator at 1 kHz offset from the carrier is -94 dBc/Hz and -88 dBc/Hz, for the low and high frequency modes, respectively, with a far from carrier noise of -143 dBc/Hz.
The Effort-Reward Imbalance model of psychosocial stress at the workplace—a comparison of ERI exposure assessment using two estimation methods

It is not unusual for old data to be used in epidemiological studies. Recently developed instruments for measuring work-related stress did not exist when the data collection was carried out. Therefore, approximate questions are sometimes used. An apparent problem is the lack of validation of proxy questions. The aim of this study was to compare the original questions for measuring Effort-Reward Imbalance (ERI) with approximate questions. The study population corresponded with a subgroup in the WOLF-n (WOrk, Lipids, Fibrinogen–north) cohort study of cardiovascular risk in a working population in the north of Sweden: 655 men and 178 women. The agreement in exposure between the original and the approximate ERI single questions was relatively low throughout, whereas the correlation between the ERI subscales and the ERI ratios was reasonable. The latter agreement between the original and the approximate ERI ratio indicates that the approximate measures might have been useful in the past. Yet, whenever possible the implementation of the original questionnaire in study protocols is recommended since a complete measurement of ERI might help to further improve the internal consistency and the predictive validity of this exposure to effort-reward imbalance.
Tale of a multifaceted co-activator, hADA3: from embryogenesis to cancer and beyond

Human ADA3, the evolutionarily conserved transcriptional co-activator, remains the unified part of multiple cellular functions, including regulation of nuclear receptor functions, cell proliferation, apoptosis, senescence, chromatin remodelling, genomic stability and chromosomal maintenance. The past decade has witnessed exciting findings leading to considerable expansion in research related to the biology and regulation of hADA3. Embryonic lethality in homozygous knockout Ada3 mouse signifies the importance of this gene product during early embryonic development. Moreover, the fact that it is a novel target of Human Papillomavirus E6 oncoprotein, one of the most prevalent causal agents behind cervical cancer, helps highlight some of the crucial aspects of HPV-mediated oncogenesis. These findings imply the central involvement of hADA3 in regulation of various cellular functional losses accountable for the genesis of malignancy and viral infections. Recent reports also provide evidence for post-translational modifications of hADA3 leading to its instability and contributing to the malignant phenotype of cervical cancer cells. Furthermore, its association with poor prognosis of breast cancer suggests intimate association in the pathogenesis of the disease. Here, we present the first review on hADA3 with a comprehensive outlook on the molecular and functional roles of hADA3 to provoke further interest for more elegant and intensive studies exploring assorted aspects of this protein.
The Epistemological Auiology of Evers and Lakomski: Some un-Quineian Quibblings

quibbling and the authors are, in=Nietzsche’s phrase, ’human, all too human. &dquo; I am sure they will allow me this reservation, especially as they have so kindly devoted a chapter to ’Hodgkinson on Humanism. ’ Given the constraints of time and space I shall confine my comments not to this excellent chapter ivith which I can hardly find fault but instead to quibblings of the academic variety about Chapter Eight ’Ethical Theory and Educational Administration’ and Chapter Nine ’Policy Analysis: Values and Complexity. ’ The . former is, I think, more directly attributable to Colin Evers and where authorship is concerned will hereinafter be referred to as EL (for EversLakomski), while conversely the latter will be referred to as LE (for Lakomski-Evers). Between them, in these two chapters, EL and LE lead us a merry dance. ’About it and about’ as Omar Khayyam might say2: EL treading a dainty minuet about the value-fact distinction and LE leading us in a stately pavane through that entangled web of conceptual confusion known as policy analysis. It is all educative, informing, entertaining but yes, there are difficulties. It is these difficulties that I shall
Supporting Architects in Mastering the Complexity of Open Software Ecosystems

Software ecosystems define a new class of systems where multiple organizations contribute in form of an open software system and its extensions. In this position paper, we characterize business, organizational, and in particular technical challenges, which the architect of such an open ecosystem has to address. One key challenge we identified is how to retain certain system qualities under the influence of multiple external system extensions. We provide an initial template with factors and potential values helping an architect in characterizing the open software system and its environment. Furthermore, we illustrate an open system by a fictional scenario from the agricultural domain. The discussion of the challenges, the characterization template and the example are significant steps towards a systematic engineering method establishing open ecosystems.
The Potential Roles of the G1LEA and G3LEA Proteins in Early Embryo Development and in Response to Low Temperature and High Salinity in Artemia sinica

Late embryogenesis abundant proteins (LEA) are stress resistance-related proteins that play crucial roles in protecting against desiccation, cold and high salinity in a variety of animals and plants. However, the expression pattern, distribution and functions of LEA proteins in the post-diapause period of Artemia sinica, and under high salinity and low temperature stresses, remain unknown. In this study, the complete cDNA sequences of the group 1 LEA (As-g1lea) and group 3 LEA (As-g3lea) genes from A. sinica were cloned. The expression patterns and location of As-G1LEA and As-G1LEA were investigated. The protein abundances of As-G1LEA, As-G3LEA and Trehalase were analyzed during different developmental stages of the embryo and under low temperature and high salinity stresses in A. sinica. The full-length cDNA of As-g1lea was 960 bp, encoding a 182 amino acid protein, and As-g3lea was 2089 bp, encoding a 364 amino acid protein. As-g1lea and As-g3lea showed their highest expressions at 0 h of embryonic development and both showed higher relative expression in embryonic, rather than adult, development stages. The abundances of As-G1LEA, As-G3LEA and trehalose were upregulated under low temperature and downregulated under high salinity stress. These two genes did not show any tissue or organ specific expression. Our results suggested that these LEA proteins might play a pivotal role in stress tolerance in A. sinica
Fractional branes and dynamical supersymmetry breaking

We study the dynamics of fractional branes at toric singularities, including cones over del Pezzo surfaces and the recently constructed Y p,q theories. We find that generically the field theories on such fractional branes show dynamical supersymmetry breaking, due to the appearance of non-perturbative superpotentials. In special cases, one recovers the known cases of supersymmetric infrared behaviors, associated to SYM confinement (mapped to complex deformations of the dual geometries, in the gauge/string correspondence sense) or N = 2 fractional branes. In the supersymmetry breaking cases, when the dynamics of closed string moduli at the singularity is included, the theories show a runaway behavior (involving moduli such as FI terms or equivalently dibaryonic operators), rather than stable non-supersymmetric minima. We comment on the implications of this gauge theory behavior for the infrared smoothing of the dual warped throat solutions with 3-form fluxes, describing duality cascades ending in such field theories. We finally provide a description of the different fractional branes in the recently introduced brane tiling configurations.
CSCL scripts: modelling features and potential use

The design of collaboration scripts is a new focus of research within the CSCL community. In order to support the design, communication, analysis, simulation and even execution of collaboration scripts, a general specification language to describe collaboration scripts is needed. In this paper, we analyse the suitability and limitations of IMS LD for modelling collaborative learning processes. Based on the analysis, we propose a CSCL scripting language. This paper presents the conceptual framework of this modelling language and the underlying design ideas. Furthermore, two developed CSCL script authoring tools are briefly described. Finally, we discuss potential types of usage and system support possibilities of CSCL scripts.
Entre femmes [Les domestiques et leurs patronnes]

Frauen untereinander. Die Untersuchung der Beziehung zwischen amerikanischen schwarzen Hausangestelltinnen und deren weisen Chefinnen gilt der Erforschung einer Situation, in der drei Typen von Macht am Werk sind : Macht gegrundet auf der Hierarchie der Klassen, der Rassen und der Geschlechter (gender). Die Analyse der Arbeitsbedingungen und der Art, in der jede der Frauen diese Situation erlebt, deckt die Bedeutung auf, die zwischenmenschlichen Ritualen der Ehrerbietung und des Maternalismus zukommen. Sie sind (wie niedriger Lohn und fehlendes Prestige) dieser Beziehung inharent und erfullen eine zentrale ideologishe Funktion ; diese wiederum hilft, das Weiterbestehen dieser Form von Arbeit und die Fortdauer eines auf Ungleichheiten begrundeten sozialen Systems zu erklaren.
A General Framework for Robust Output Synchronization of Heterogeneous Nonlinear Networked Systems

The paper aims to establish a general framework for robust output synchronization of a group of networked agents. The agents under investigation have nonlinear, uncertain and heterogeneous dynamics. Output synchronization denotes that all agents, through collaborative control, achieve output agreement and follow a desired pattern. In particular, the agreed trajectory is not defined by nor known to any agent in advance. Collaborative control is achieved using only output information from neighboring agents. Two concurrent actions are revealed in the proposed synchronization framework. This framework involves design strategies for both perturbed consensus and perturbed regulation problems, subject to a class of small gain conditions. The success of the framework is verified by constructive proof and numerical simulation.