Miracle-dz/UniFAR-FTUs huggingface dataset:
O⁶-carboxymethylguanine DNA adduct formation and lipid peroxidation upon in vitro gastrointestinal digestion of haem-rich meat.

SCOPE Epidemiological and clinical studies have demonstrated that the consumption of red haem-rich meat may contribute to the risk of colorectal cancer. Two hypotheses have been put forward to explain this causal relationship, i.e. N-nitroso compound (NOC) formation and lipid peroxidation (LPO). METHODS AND RESULTS In this study, the NOC-derived DNA adduct O(6)-carboxymethylguanine (O(6)-CMG) and the LPO product malondialdehyde (MDA) were measured in individual in vitro gastrointestinal digestions of meat types varying in haem content (beef, pork, chicken). While MDA formation peaked during the in vitro small intestinal digestion, alkylation and concomitant DNA adduct formation was observed in seven (out of 15) individual colonic digestions using separate faecal inocula. From those, two haem-rich meat digestions demonstrated a significantly higher O(6)-CMG formation (p < 0.05). MDA concentrations proved to be positively correlated (p < 0.0004) with haem content of digested meat. The addition of myoglobin, a haem-containing protein, to the digestive simulation showed a dose-response association with O(6)-CMG (p = 0.004) and MDA (p = 0.008) formation. CONCLUSION The results suggest the haem-iron involvement for both the LPO and NOC pathway during meat digestion. Moreover, results unambiguously demonstrate that DNA adduct formation is very prone to inter-individual variation, suggesting a person-dependent susceptibility to colorectal cancer development following haem-rich meat consumption.
Characters of coinvariants in (1,p) logarithmic models

We investigate induced modules of doublet algebra in (1,p) logarithmic models. We give fermionic formulas for the characters of induced modules and coinvariants with respect to different subalgebras calculated in the irreducible modules. The characters of coinvariants give multiplicities of projective modules in fusion of induced modules.
Maximizing Network Utilization in Hybrid Software-Defined Networks

By separating the control and forwarding planes, Software-Defined networking (SDN) enables the forwarding paths to be flexibly controlled by the logically centralized controllers using the global network view. To introduce SDN into existing networks, it is necessary to upgrade traditional devices to SDN- enabled ones. However, due to the business, economic and management limitations, it is difficult to realize full SDN deployment. As a result, how to migrate existing devices to SDN-compliant ones becomes the obvious dilemma for every network operator. In this paper, we address this question from the network performance perspective, and study how to leverage the capability of SDN to maximize traffic flow that can be achieved in hybrid SDNs. We formulate the maximum flow problem in networks with partial SDN deployment, and develop a fast Fully Polynomial Time Approximation Scheme (FPTAS) for solving it. Simulation results using real topologies show that hybrid SDNs outperform traditional networks, and we can obtain a near optimal network performance when 50% of SDN nodes are deployed.
A Novel$Sigma$&#8211;$Delta$Pulsed Digital Oscillator (PDO) for MEMS

A novel digital oscillator topology for microelectromechanical systems (MEMS) based on bandpass sigma–delta modulation is presented. Short pulses of force of the same amplitude maintain the oscillation and the associated bit-stream output serves to know the oscillation frequency which, for low mechanical losses, is very close to the natural frequency of the MEMS resonator. Position-sensing requirements are extremely simplified because, at each sampling time, it is only necessary to know whether the resonator position is above or below the steady-state position. Continuous-time simulations are presented showing the behavior of the oscillator for different sampling frequencies and mechanical damping losses. Experimental results from an oscillator using a MEMS resonator with thermoelectric actuation and piezoresitive position sensing are presented. It is concluded that the quality of the oscillator response depends on the resonator damping losses and on the sampling frequency. The experimental results agree with the analytical and simulation results.
Self-Development, Social Support, and Student Help-Seeking

Abstract College psychotherapists and student development professionals need to better understand which students utilize available supports on campus, when positive outcomes are due to intervention effects versus participant self-selection, and whether supportive experiences have different effects depending on developmental differences among participants. This article reports on an ongoing research program investigating interventions for a diverse range of college clientele, including: first-year experience classes, peer mentoring for African Americans at predominantly White institutions, mandated counseling for at-risk financial aid students, adult distance learners, and women counseling clients with eating disorders. Findings from the ongoing research suggest three tentative themes: (1) support services tend to be most utilized by developmentally low-risk students; (2) participants tend to prefer programs providing high social support, versus self-directed, less engaging interventions; and (3) regarding intervention effects, interactions cause a curvilinear relationship between self-development, provision of support, and program outcomes. Counseling implications and directions for continued research are discussed.
Potentially functional COX‐2 −1195G>A polymorphism increases the risk of digestive system cancers: A meta‐analysis

Background and Aim: Three potentially functional polymorphisms: −765G>C, −1195G>A, and 8473T>C in the cyclooxygenase‐2 (COX‐2) gene were identified and proposed to be associated with cancer susceptibility. The aim of this meta‐analysis was to evaluate the association between these three polymorphisms and the risk of cancer in diverse populations.
Knowing Nothing: Understanding New Critical Social Work Practice

Individuals embarking on their journey to become professional social workers often state they feel as if they know nothing upon entering their practice. Regardless of the number of years critical social workers have practiced, they are also thought to know â€œnothing. â€ By utilizing a philosophical hermeneutic approach I chose to recognize that new critical social work ideas, theories and practices come from something and somewhere (Moules, 2002). This hermeneutic study involved interviewing six newly graduated social workers from with a declared critical orientation. I asked these budding new professionals to describe what happens when they begin working in organizations that may or may not support a critical ideology and how this influences their practice. Hermeneutic interpretations of the participant experiences suggest that this â€œnothingâ€ is not devoid of meaning or method, but instead involves insinuating themselves and their ideas into their agencies in a delicate curvilinear manner.
Mitotic spindle rotation and mode of cell division in the developing telencephalon

The mode of neural stem cell division in the forebrain proliferative zones profoundly influences neocortical growth by regulating the number and diversity of neurons and glia. Long-term time-lapse multiphoton microscopy of embryonic mouse cortex reveals new details of the complex three-dimensional rotation and oscillation of the mitotic spindle before stem cell division. Importantly, the duration and amplitude of spindle movement predicts and specifies the eventual mode of mitotic division. These technological advances have provided dramatic data and insights into the kinetics of neural stem cell division by elucidating the involvement of spindle rotation in selection of the cleavage plane and the mode of neural stem cell division that together determine the size of the mammalian neocortex.
Body mass index, waist circumference, and clustering of cardiovascular disease risk factors in a biracial sample of children and adolescents.

OBJECTIVE To derive optimal body mass index (BMI) and waist circumference thresholds for children and adolescents, to predict risk factor clustering. DESIGN Cross-sectional receiver operating characteristic curve analysis. SETTING The Bogalusa Heart Study, a community-based study of cardiovascular disease risk factors in early life. PARTICIPANTS A total of 2597 black and white children and adolescents, 5 to 18 years of age, who were examined between 1992 and 1994. MAIN OUTCOME MEASURES The presence or absence of > or =3 age-adjusted risk factors (low high-density lipoprotein cholesterol level, high low-density lipoprotein cholesterol level, high triglyceride level, high glucose level, high insulin level, and high blood pressure) was predicted from age-adjusted BMI and waist circumference values. RESULTS The areas under the receiver operating characteristic curves were significantly different from 0.5 for both BMI and waist circumference for all gender/race groups, ranging from 0.73 to 0.82. The optimal BMI thresholds were at the 53rd and 50th percentiles for white and black male subjects, respectively, and at the 57th and 51st percentiles for white and black female subjects, respectively. Similarly, the optimal waist circumference thresholds were at the 56th and 50th percentiles for white and black male subjects, respectively, and at the 57th and 52nd percentiles for white and black female subjects, respectively. The sensitivity and specificity at the thresholds were similar for all gender/race groups, ranging from 67% to 75%. CONCLUSIONS The use of BMI and waist circumference for the prediction of risk factor clustering among children and adolescents has significant clinical utility. In this sample, race and gender differences in the optimal thresholds were minimal.
Vulnerability to Psychosis : From Neurosciences to Psychopathology

Borgwardt, Fusar-Poli, McGuire, Introduction. Broome, Dale, Marriott, Merino, Bortolotti, Neuroscience, Continua and the Prodromal Phase of Psychosis. Yung, Wood, Nelson, Defining the Risk for Psychosis: Can Neuroscience Help Psychopathology? Piccchioni, Toulopoulou, Genetic Determinants of the Vulnerability to Psychosis: Findings from Twin Studies. Day, Pariante, Stress and Cortisol in the Pre-psychotic Phases. Pukrop, Ruhrmann, Neurocognitive Indicators of High-risk States for Psychosis. Borgwardt, Fusar-Poli, Riecher- Rossler, McGuire, Grey Matters: Mapping the Transition to Psychosis. Fusar-Poli, Agosti, Borgwardt, Functional MRI in Prodromal Psychosis. Stone, Glutamate: Gateway to Psychosis? Howes, Does Dopamine Start the Psychotic "Fire"? Chrossley, Bramon, Neurophysiological Alterations in the Pre-psychotic Phases. Yang, Wonpat-Borja, Opler, Compton, Kelly, Purdie-Vaughns, Corcoran, Stigma in Early Stages of Psychotic Illness: Connections with Cognitive Neuroscience. McGuire, Conclusions.
Job satisfaction as a mediator of the relationship between role stressors and organizational commitment: A study from an Arabic cultural perspective

This paper investigates the potential mediating role of job satisfaction between role stressors, namely role conflict and role ambiguity as sources of stress, on the one hand, and various facets of organizational commitment, namely affective, continuance and normative, on the other. A sample of 361 employees in a number of organizations in the United Arab Emirates was used. Path analysis revealed that role ambiguity directly and negatively influences both affective and normative commitments. Results also revealed that job satisfaction directly and positively influences affective and normative commitments and negatively influences continuance commitment‐low perceived alternatives. Results further suggest that both role conflict and role ambiguity directly and negatively influence job satisfaction. It was also found that job satisfaction mediates the influences of role conflict and role ambiguity on various facets of organizational commitment, except continuance commitment‐high personal sacrifice. Implications, future lines of research and limitations are discussed.
RESTENOSIS AFTER BALLOON ANGIOPLASTY AND / OR STENT INSERTION a ORIGIN AND PREVENTION A review of the literature

Due to research advances in vascular biology, assessment of the vasculature as a conduit for circulating blood has been successively revisited during the past century. At present, the vasculature is known as a complex organ, capable of synthesizing and secreting a wide variety of biological mediators and responding to numerous chemical and mechanical signals. Obstructive vascular disease, mainly atherosclerosis, can disturb these functions and cause serious clinical symptoms (42, 169, 170). Diagnostic and therapeutic options have changed substantially during recent decades. Interventional treatment methods such as percutaneous transluminal angioplasty (PTA) and insertion of vascular metallic endoprosthesesa stents (32, 37, 39, 57, 77, 106, 110, 145, 172)ahave in many cases replaced traditional vascular surgery. However, PTA and/or the insertion of stents also causes injury to the vessel wall, followed by a healing process (48, 50, 101, 106, 165, 189). This reparative process can result in restenosis, caused by intimal hyperplasia (IH) and a remodeling of the artery, also called chronic spasm (128, 154, 155, 221). Significant restenosis develops in 20–50% of treated
Erlotinib or Docetaxel for Second-Line Treatment of Non-small Cell Lung Cancer: A Real-World Cost-Effectiveness Analysis

Introduction: Erlotinib was recently approved in British Columbia (BC) as a second-line treatment for advanced NSCLC. A cost-effectiveness analysis was conducted which compares costs and effectiveness in patients who received second-line erlotinib with those in patients who received docetaxel. Methods: In a population of patients who have been treated with drugs (either erlotinib or docetaxel) for advanced NSCLC, overall survival (OS), progression-free survival (PFS), and probability of survival 1 year after beginning of second-line treatment (1YS) were determined using Kaplan-Meier and Cox proportional hazard analysis, as well as &khgr;2 test. Costs were collected retrospectively from the perspective of the BC health care system. Results: Incremental mean OS was 1 day, and incremental mean cost was $2891. Neither costs nor effectiveness were statistically significantly different between groups. PFS and 1YS were also nonsignificantly different. Cox proportional hazard models were used to evaluate multivariate confounding. Conclusions: Erlotinib and docetaxel are statistically equivalent in terms of treatment cost and overall survival. As treatment practice patterns change, docetaxel may become more frequently prescribed. Therefore, the choice of whether to use erlotinib or docetaxel should be based on factors relating to patient preference rather than costs or effectiveness.
Highly efficient 24-GHz CMOS linear power amplifier with an adaptive bias circuit

A 24 GHz Power amplifier (PA) with high efficiency designed in the 0.13-μm CMOS process is presented. The proposed adaptive-bias circuit is used to improve the efficiency. The quiescent power consumption is 79.2 mW, which is improved by 53.8mW, compared to that of the optimized fixed-biased (0.6V) PA. Power added efficiency (PAE) and output power (POUT) at a 1-dB-gain-compression-power (P1dB) is 15.6 % and 13.3 dBm, respectively. This result is improved as much as 4% and 1.2dB, compare to that of PA with fixed-bias of 0.6V.
Random Projection Random Discretization Ensembles—Ensembles of Linear Multivariate Decision Trees

In this paper, we present a novel ensemble method random projection random discretization ensembles(RPRDE) to create ensembles of linear multivariate decision trees by using a univariate decision tree algorithm. The present method combines the better computational complexity of a univariate decision tree algorithm with the better representational power of linear multivariate decision trees. We develop random discretization (RD) method that creates random discretized features from continuous features. Random projection (RP) is used to create new features that are linear combinations of original features. A new dataset is created by augmenting discretized features (created by using RD) with features created by using RP. Each decision tree of a RPRD ensemble is trained on one dataset from the pool of these datasets by using a univariate decision tree algorithm. As these multivariate decision trees (because of features created by RP) have more representational power than univariate decision trees, we expect accurate decision trees in the ensemble. Diverse training datasets ensure diverse decision trees in the ensemble. We study the performance of RPRDE against other popular ensemble techniques using C4.5 tree as the base classifier. RPRDE matches or outperforms other popular ensemble methods. Experiments results also suggest that the proposed method is quite robust to the class noise.
Fusões e aquisições no Brasil: reflexões acerca da evolução do volume de transações

Este estudo analisa o desenvolvimento do volume de Fusoes e Aquisicoes (F&A) no Brasil e sua relacao com fatores macroeconomicos que possivelmente explicam seu comportamento. Nesse sentido, realizou-se uma revisao de literatura e analises de dados secundarios disponibilizados pela KPMG no periodo de 2002 a 2013. As reflexoes exploraram os fatores influenciadores desempenhados pelo governo brasileiro e o mercado externo considerando-se duas perspectivas: a origem do capital e setor de atuacao das empresas envolvidas. Os dados sugerem que o mercado brasileiro apresentou um amadurecimento visto que se observou uma tendencia de crescimento de forma sustentavel no periodo, mesmo com diferentes forcas macroeconomicas internas e externas atuando. Destaca-se como contribuicoes deste estudo a ampliacao da compreensao das mudancas economicas que expliquem a evolucao das F&A no Brasil em um periodo que abrange significativas turbulencias e instabilidades economicas mundialmente.
Do electromagnetic fields interact with electrons in the Na,K‐ATPase?

The effects of low frequency electric and magnetic fields on several biochemical systems, including the Na,K‐ATPase, indicate that electromagnetic (EM) fields interact with electrons. The frequency optima for two enzymes in response to EM fields are very close to their turnover numbers, suggesting that these interactions directly affect reaction rates. Nevertheless, generally accepted ideas about Na,K‐ATPase function and ion transport mechanisms do not consider interactions with electrons. To resolve the clash of paradigms, we hypothesize interaction with transient electrons and protons that arise from flickering of H‐bonds in the hydrated protein. These transient charges in the enzyme could provide a trigger for the sequence of conformation changes that are part of the ion transport mechanism. If the distributions of transient electrons and protons in the membrane are affected by their concentration and the membrane potential, as expected from electric double layer theory, this can account for the different effects of low frequency electric and magnetic fields, as well as for the observation that membrane hyperpolarization reverses the ATPase reaction to generate ATP. Bioelectromagnetics © 2005 Wiley‐Liss, Inc.
Transient and Permanent Error Control for High-End Multiprocessor Systems-on-Chip

High-end MPSoC systems with built-in high-radix topologies achieve good performance because of the improved connectivity and the reduced network diameter. In high-end MPSoC systems, fault tolerance support is becoming a compulsory feature. In this work, we propose a combined method to address permanent and transient link and router failures in those systems. The LBDRhr mechanism is proposed to tolerate permanent link failures in some popular high-radix topologies. The increased router complexity may lead to more transient router errors than routers using simple XY routing algorithm. We exploit the inherent information redundancy (IIR) in LBDRhr logic to manage transient errors in the network routers. Thorough analyses are provided to discover the appropriate internal nodes and the forbidden signal patterns for transient error detection. Simulation results show that LBDRhr logic can tolerate all of the permanent failure combinations of long-range links and 80% of links failures at short-range links. Case studies show that the error detection method based on the new IIR extraction method reduces the power consumption and the residual error rate by 33% and up to two orders of magnitude, respectively, compared to triple modular redundancy. The impact of network topologies on the efficiency of the detection mechanism has been examined in this work, as well.
Personality Influences On Marital Satisfaction: An Examination Of Actor, Partner, And Interaction Effects

PERSONALITY INFLUENCES ON MARITAL SATISFACTION: AN EXAMINATION OF ACTOR, PARTNER, AND INTERACTION EFFECTS Publication No. ______ Mahnaz Rehmatullah Charania, PhD. The University of Texas at Arlington, 2006 Supervising Professor: William Ickes The current research was designed to examine the associations between married partners’ personalities and their marital satisfaction. The major goal of this research was to examine the unique predictive validity of 13 personality traits in an omnibus model in which the effects of all 13 traits were tested simultaneously. The data were analyzed using the Actor-Partner Interdependence Model (APIM), which enabled me to examine the effect of each personality variable (1) as a function of each participant’s own trait score (an actor effect), (2) as a function of each participant’s partner’s trait score (a partner effect), and (3) as a function of the interaction between the actor and partner’s iii trait scores for each of the 13 traits assessed. The results revealed significant actor effects for openness to experience (-), conscientiousness (+), agreeableness (+), anxious attachment (-), social absorption (+), and sociosexuality (-), and significant partner effects for extraversion (-), psychological femininity (+), anxious attachment (-), social absorption (+), and sociosexuality (-). I also observed actor and partner effects for sensation seeking, both of which were qualified by the actor and partner’s genders, respectively. I further observed significant effects of partner similarity for avoidant attachment and social individuation and significant partner interactions for anxious attachment and social absorption. The results from the current study confirm the importance of examining actor, partner, and interaction effects of personality on marital satisfaction, as well as the importance of examining relationship-specific variables because of the greater specificity (compared to the Big Five) that they offer in understanding individual cognitions and behaviors within the context of a marriage relationship.
FEIDHE (a project) / Electronic Identification in Finnish Higher Education

In Finnish universities and polytechnics students and staff members have access to several information systems and services requiring user authentication. Traditionally authentication is based on username-passwords pairs. In the information systems the passwords or alternatively, some one-way hash values deriving from them are stored in a user database. When the user is to be authenticated to the system, one is prompted to enter one’s username and password, which are then compared to the data stored in the database. If the username-password pair correspond to ones in the user database, access is granted to the resources that are available for the user.