Miracle-dz/UniFAR-FTUs huggingface dataset:
The Evolving Landscape of Thromboembolic Disease: Diagnostic and Management Strategies.

The landscape of anticoagulant therapy for atrial fibrillation and deep-vein thrombosis has evolved considerably in the last decade with the advent of Novel or Direct-Acting Oral Antiocoagulants (DOACs). The initial phase III randomized controlled trials established the individual DOACs as viable alternatives to warfarin for thromboprophylaxis but generalizations to the larger population were limited by the small number of protocol subjects with renal insufficiency, congestive heart failure, advanced age and other comorbidities. All the DOACs have some degree of renal excretion and while safe and effective in patients with mild to moderate renal insufficiency, dose adjustment is necessary based on creatinine clearance. Subsequent data registries and real-world experience with DOACs have continued to refine their role in these particular patient subgroups. Off-label use with both underand overdosing is not uncommon in renal failure and carries increased risk. Their increasing use among the elderly, in patients with heart failure, hepatic and renal insufficiency and among the Asian population has been shown to be relatively safe and effective compared to warfarin. Gaps in our current understanding of this new class of anticoagulants will continue to narrow as additional data becomes available through ongoing registries and real-world experience.
The Effects of Image Dehazing Methods Using Dehazing Contrast-Enhancement Filters on Image Compression

To obtain well-dehazed images at the receiver while sustaining low bit rates in the transmission pipeline, this paper investigates the effects of image dehazing methods using dehazing contrast-enhancement filters on image compression for surveillance systems. At first, this paper proposes a novel image dehazing method by using a new method of calculating the transmission function—namely, the direct denoising method. Next, we deduce the dehazing effects of the direct denoising method and image dehazing method based on dark channel prior (DCP) on image compression in terms of ringing artifacts and blocking artifacts. It can be concluded that the direct denoising method performs better than the DCP method for decompressed (reconstructed) images. We also improve the direct denoising method to obtain more desirable dehazed images with higher contrast, using the saliency map as the guidance image to modify the transmission function. Finally, we adjust the parameters of dehazing contrast-enhancement filters to obtain a corresponding composite peak signal-to-noise ratio (CPSNR) and blind image quality assessment (BIQA) of the decompressed images. Experimental results show that different filters have different effects on image compression. Moreover, our proposed dehazing method can strike a balance between image dehazing and image compression.
Structural social relations and cognitive ageing trajectories: evidence from the Whitehall II cohort study.

Background Social relations are important for health, particularly at older ages. We examined the salience of frequency of social contacts and marital status for cognitive ageing trajectories over 21 years, from midlife to early old age. Methods Data are from the Whitehall II cohort study, including 4290 men and 1776 women aged 35-55 years at baseline (1985-88). Frequency of social contacts and marital status were measured in 1985-88 and 1989-90. Assessment of cognitive function on five occasions (1991-94, 1997-99, 2003-04, 2007-09 and 2012-13) included the following tests: short-term memory, inductive reasoning, verbal fluency (phonemic and semantic) and a combined global score. Cognitive trajectories over the study period were analysed using longitudinal latent growth class analyses, and the associations of these latent classes (trajectory memberships) with social relations were analysed using multinominal logistic regression. Results More frequent social contacts [relative risk (RRR) 0.96, 95% confidence interval (CI) 0.94 - 0.98] and being married (RRR 0.70, 95% CI 0.58 - 0.84) were associated with lower probability of being on a low rather than high cognitive performance trajectory over the subsequent 21 years. These associations persisted after adjustment for covariates. Of the sub-tests, social relations variables had the strongest association with phonemic fluency (RRR 0.95, 95% CI 0.94 - 0.97 for frequent contact; RRR 0.59, 95% CI 0.48 - 0.71 for being married). Conclusions More frequent social contacts and having a spouse were associated with more favourable cognitive ageing trajectories. Further studies are needed to examine whether interventions designed to improve social connections affect cognitive ageing.
New stimulation regimens: endogenous and exogenous progesterone use to block the LH surge during ovarian stimulation for IVF

BACKGROUND The advent of embryo and oocyte vitrification today gives reproductive specialists an opportunity to consider new strategies for improving the practice and results of IVF attempts. As the freezing of entire cohorts does not compromise, and may even improve, the results of IVF attempts, it is possible to break away from the standard sequence of stimulation-retrieval-transfer. The constraints associated with ovarian stimulation in relation to the potential harmful effects of the hormonal environment on endometrial receptivity can be avoided. OBJECTIVE AND RATIONALE This review will look at the new stimulation protocols where progesterone is used to block the LH surge. Thanks to 'freeze all' strategies, the increase in progesterone could actually be no longer a cause for concern. There are two ways of using progesterone, whether it be endogenous, as in luteal phase stimulation, or exogenous, as in the use of progesterone in the follicular phase i.e. progestin primed ovarian stimulation. SEARCH METHODS A literature search was carried out (until September 2016) on MEDLINE. The following text words were utilized to generate the list of citations: progestin primed ovarian stimulation, luteal phase stimulation, luteal stimulation, duostim, double stimulation, random start. Articles and their references were then examined in order to identify other potential studies. All of the articles are reported in this review. OUTCOMES The use of progesterone during ovarian stimulation is effective in blocking the LH surge, whether endogenous or exogenous, and it does not affect the number of oocytes collected or the quality of the embryos obtained. Its main constraint is that it requires total freezing and delayed transfer. A variety of stimulation protocols can be derived from these two methods, and their implications are discussed, from fertility preservation to ovarian response profiles to organization for the patients and clincs. These new regimens enable more flexibility and are of emerging interest in daily practice. However, their medical and economic significance remains to be demonstrated. WIDER IMPLICATIONS The use of luteal phase or follicular phase protocols with progestins could rapidly develop in the context of oocyte donation and fertility preservation not related to oncology. Their place could develop even more in the general population of patients in IVF programs. The strategy of total freezing continues to develop, thanks to technical improvements, in particular vitrification and PGS on blastocysts, and thanks to studies showing improvements in embryo implantation when the transfer take place far removed from the hormonal changes caused by ovarian stimulation.
Optimal Status Update for Age of Information Minimization With an Energy Harvesting Source

In this paper, we consider a scenario where an energy harvesting sensor continuously monitors a system and sends time-stamped status updates to a destination. The destination keeps track of the system status through the received updates. We use the metric Age of Information (AoI), the time that has elapsed since the last received update was generated, to measure the “freshness” of the status information available at the destination. Our objective is to design optimal online status update policies to minimize the long-term average AoI, subject to the energy causality constraint at the sensor. We consider three scenarios, i.e., the battery size is infinite, finite, and one unit only, respectively. For the infinite battery scenario, we adopt a best-effort uniform status update policy and show that it minimizes the long-term average AoI. For the finite battery scenario, we adopt an energy-aware adaptive status update policy, and prove that it is asymptotically optimal when the battery size goes to infinity. For the last scenario where the battery size is one, we first show that within a broadly defined class of online policies, the optimal policy should have a renewal structure. We then focus on a renewal interval, and prove that the optimal policy should have a threshold structure, i.e., if the AoI in the system is below a threshold when an energy arrival enters an empty battery, the sensor should store the energy first and then update when the AoI reaches the threshold; otherwise, it updates the status immediately. Simulation results corroborate the theoretical bounds.
Optimal Antithrombin Activity Threshold for Initiating Antithrombin Supplementation in Patients With Sepsis-Induced Disseminated Intravascular Coagulation: A Multicenter Retrospective Observational Study

Low-dose antithrombin supplementation therapy (1500 IU/d for 3 days) improves outcomes in patients with sepsis-induced disseminated intravascular coagulation (DIC). This retrospective study evaluated the optimal antithrombin activity threshold to initiate supplementation, and the effects of supplementation therapy in 1033 patients with sepsis-induced DIC whose antithrombin activity levels were measured upon admission to 42 intensive care units across Japan. Of the 509 patients who had received antithrombin supplementation therapy, in-hospital mortality was significantly reduced only in patients with very low antithrombin activity (≤43%; bottom quartile; adjusted hazard ratio: 0.603; 95% confidence interval: 0.368-0.988; P = .045). Similar associations were not observed in patients with low, moderate, or normal antithrombin activity levels. Supplementation therapy did not correlate with the incidence of bleeding requiring transfusion. The adjusted hazard ratios for in-hospital mortality increased gradually with antithrombin activity only when initial activity levels were very low to normal but plateaued thereafter. We conclude that antithrombin supplementation therapy in patients with sepsis-induced DIC and very low antithrombin activity may improve survival without increasing the risk of bleeding.
The impact of potentially traumatic events on the mental health of males who have served in the military: Findings from the Australian National Survey of Mental Health and Wellbeing

Objective: The study investigated the impact of potentially traumatic events on mental health outcomes among males who had ever served in the Australian Defence Force. Method: Data from a nationally representative household survey of Australian residents, the 2007 National Survey of Mental Health and Wellbeing, were used for this study. Results: Compared with community members, Australian Defence Force males were significantly more likely to have experienced not only deployment and other war-like events but also accidents or other unexpected events, and trauma to someone close. For non-deployed males, Australian Defence Force members were at increased risk of accidents or other unexpected events compared to community members. After controlling for the effect of potentially traumatic events that were more prevalent among all Australian Defence Force members, the increased risk of mental disorders among Australian Defence Force members was no longer evident. For non-deployed males, Australian Defence Force and community members were at comparable risk of poor mental health outcomes. A significant minority of Australian Defence Force members had onset of a mental disorder prior to their first deployment. Conclusions: Deployment and other potentially traumatic events among Australian Defence Force members can help to explain their increased vulnerability to mental disorders compared with community members. Providers should routinely enquire about a range of potentially traumatic events among serving and ex-serving military personnel.
Intimate Partner Violence in the First 2 Years of Life: Implications for Toddlers’ Behavior Regulation

Intimate partner violence (IPV) is prevalent in families with young children and challenges their healthy development. This study examined characteristics of IPV (e.g., mother- vs. partner-perpetrated, types and severity) and investigated potential effects of IPV on toddlers’ behavioral regulation in a sample of families at risk for IPV. We also examined whether maternal depression and child-rearing attitudes and behavior would moderate IPV–child behavior links. These questions were addressed in a sample (N = 400) of first-time adolescent mothers and their toddlers (1-2 years of age). Families were visited in their homes; data were collected via maternal report and observations. Partner- and self-perpetrated IPV was assessed using the Conflict Tactics Scale questionnaire; child behavior regulation was measured using the Brief Infant–Toddler Social and Emotional Assessment questionnaire. Approximately 80% of families experienced psychological aggression; almost one third reported physical assault in the past year. Both physical and psychological IPV were associated with greater toddler behavior problems. Neither maternal depression, mothers’ attitudes about corporal punishment, nor nonhostile interaction moderated IPV–behavior problem links, though mothers’ reports of maltreating behavior did. Among children whose mothers did not use corporal punishment/physical violence, IPV did not differentially affect behavior problems. Children whose mothers used corporal punishment/physical violence with them showed behavior problems in the context of IPV (severe psychological aggression). Results underscore the importance of exposure to IPV during the first year of life, and the prevalence of IPV perpetrated by both mothers and their partners in families with adolescent mothers.
Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals

Goda et al. provide molecular evidence that body temperature rhythm (BTR) is regulated distinctly from locomotor activity rhythms and show that diuretic hormone 31 receptor/calcitonin receptor is an ancient specific mediator of BTR during the active phase in organisms ranging from ectotherms to endotherms.
Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm

Importance Risk factors for abdominal aortic aneurysm (AAA) are largely unknown, which has hampered the development of nonsurgical treatments to alter the natural history of disease. Objective To investigate the association between lipid-associated single-nucleotide polymorphisms (SNPs) and AAA risk. Design, Setting, and Participants Genetic risk scores, composed of lipid trait–associated SNPs, were constructed and tested for their association with AAA using conventional (inverse-variance weighted) mendelian randomization (MR) and data from international AAA genome-wide association studies. Sensitivity analyses to account for potential genetic pleiotropy included MR-Egger and weighted median MR, and multivariable MR method was used to test the independent association of lipids with AAA risk. The association between AAA and SNPs in loci that can act as proxies for drug targets was also assessed. Data collection took place between January 9, 2015, and January 4, 2016. Data analysis was conducted between January 4, 2015, and December 31, 2016. Exposures Genetic elevation of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG). Main Outcomes and Measures The association between genetic risk scores of lipid-associated SNPs and AAA risk, as well as the association between SNPs in lipid drug targets (HMGCR, CETP, and PCSK9) and AAA risk. Results Up to 4914 cases and 48 002 controls were included in our analysis. A 1-SD genetic elevation of LDL-C was associated with increased AAA risk (odds ratio [OR], 1.66; 95% CI, 1.41-1.96; P = 1.1 × 10−9). For HDL-C, a 1-SD increase was associated with reduced AAA risk (OR, 0.67; 95% CI, 0.55-0.82; P = 8.3 × 10−5), whereas a 1-SD increase in triglycerides was associated with increased AAA risk (OR, 1.69; 95% CI, 1.38-2.07; P = 5.2 × 10−7). In multivariable MR analysis and both MR-Egger and weighted median MR methods, the association of each lipid fraction with AAA risk remained largely unchanged. The LDL-C–reducing allele of rs12916 in HMGCR was associated with AAA risk (OR, 0.93; 95% CI, 0.89-0.98; P = .009). The HDL-C–raising allele of rs3764261 in CETP was associated with lower AAA risk (OR, 0.89; 95% CI, 0.85-0.94; P = 3.7 × 10−7). Finally, the LDL-C–lowering allele of rs11206510 in PCSK9 was weakly associated with a lower AAA risk (OR, 0.94; 95% CI, 0.88-1.00; P = .04), but a second independent LDL-C–lowering variant in PCSK9 (rs2479409) was not associated with AAA risk (OR, 0.97; 95% CI, 0.92-1.02; P = .28). Conclusions and Relevance The MR analyses in this study lend support to the hypothesis that lipids play an important role in the etiology of AAA. Analyses of individual genetic variants used as proxies for drug targets support LDL-C lowering as a potential effective treatment strategy for preventing and managing AAA.
Expectation propagation as a way of life ∗

We revisit expectation propagation (EP) as a prototype for scalable algorithms that partition big datasets into many parts and analyze each part in parallel to perform inference of shared parameters. The algorithm should be particularly eﬃcient for hierarchical models, for which the EP algorithm works on the shared parameters (hyperparameters) of the model. The central idea of EP is to work at each step with a “tilted distribution” that combines the likelihood for a part of the data with the “cavity distribution,” which is the approximate model for the prior and all other parts of the data. EP iteratively approximates the moments of the tilted distributions and incorporates those approximations into a global posterior approximation. As such, EP can be used to divide the computation for large models into manageable sizes. The computation for each partition can be made parallel with occasional exchanging of information between processes through the global posterior approximation. Moments of multivariate tilted distributions can be approximated in various ways, including, MCMC, Laplace approximations, and importance sampling.
Are there any relations among transplant centre volume, surgical technique and anatomy for donor graft selection? Ten-year multicentric Italian experience on mini-invasive living donor nephrectomy

Background Selection of the right or left living donor kidney for transplantation is influenced by many variables. In the present multi centric study including 21 Italian transplant centres, we evaluated whether centre volume or surgical technique may influence the selection process. Methods Intra- and perioperative donor data, donor kidney function, and recipient and graft survival were collected among 693 mini-invasive living donor nephrectomies performed from 2002 to 2014. Centre volume (LOW, 1-50 cases; HIGH, >50 cases) and surgical technique (FULL-LAP, full laparoscopic and robotic; HA-LAP, hand-assisted laparoscopy; MINI-OPEN, mini-lumbotomy) were correlated with selection of right or left donor kidney and with donor and recipient outcome. Results HIGH-volume centres retrieved a higher rate of donor right kidneys (29.3% versus 17.6%, P < 0.01) with single artery (83.1% versus 76.4%, P < 0.05) compared with LOW-volume centres. Surgical technique correlated significantly with rate of donor right kidney and presence of multiple arteries: MINI-OPEN (53% and 13%) versus HA-LAP (29% and 22%) versus FULL-LAP (11% and 23%), P < 0.001 and P < 0.05, respectively. All donors had an uneventful outcome; donor bleeding was more frequent in LOW-volume centres (4% versus 0.9%, P < 0.05). Conclusions Centre volume and surgical technique influenced donor kidney side selection. Donor nephrectomy in LOW-volume centres was associated with higher risk of donor bleeding.
Addiction Severity and Suicidal Behaviors Among Persons Entering Treatment

The aim of this study was three-fold: to compare the rates for suicidal behaviors based on the problem substance, to look at the association between addiction severity and suicidal behaviors, and to identify the components of addiction severity associated with suicidal behaviors. Addiction Severity Index databases from three public rehabilitation centers were merged for analyses, yielding 6,551 evaluations. The rates for suicidal behaviors among those who have a problem with both alcohol and a drug are higher than for those who have a problem with any single substance. The effect of addiction severity on suicidal behaviors persists even when other problem areas are taken into account. Thus, clinicians must pay closer attention to persons with both alcohol and drug problem.
Fuzzy Stabilization of Fuzzy Control Systems

Recently there has been significant growth in the use of fuzzy logic in industrial and consumer products (J. Yen 1995). However, although fuzzy control has been successfully applied to many industrial plants that are mostly nonlinear systems, many critics of fuzzy logic claim that there is no such thing as a stability proof for fuzzy logic systems in closedloop control (Reznik 1997; Farinwata, Filev et al. 2000). Since fuzzy logic controllers are classified as "non-linear multivariable controllers" (Reznik 1997; Farinwata, Filev et al. 2000), it can be argued that all stability analysis methods applicable to these controller types are applicable to fuzzy logic controllers. Unfortunately, due to the complex non-linearities of most fuzzy logic systems, an analytical solution is not possible. Furthermore, it is important to realize that real, practical problems have uncertain plants that inevitably cannot be modelled dynamically resulting in substantial uncertainties. In addition the sensors noise and input signal level constraints affect system stability. Therefore a theory that is able to deal with these issues would be useful for practical designs. The most well-known time domain stability analysis methods include Lyapunov’s direct method (Wu & Ch. 2000; Gruyitch, Richard et al. 2004; Rubio & Yu 2007) which is based on linearization and Lyapunov’s indirect method (Tanaka & Sugeno 1992; Giron-Sierra & Ortega 2002; Lin, Wang et al. 2007; Mannani & Talebi 2007) that uses a Lyapunov function which serves as a generalized energy function. In addition many other methods have been used for testing fuzzy systems stability such as Popov’s stability criterion (Katoh, Yamashita et al. 1995; Wang & Lin 1998), the describing function method (Ying 1999; Aracil & Gordillo 2004), methods of stability indices and systems robustness (Fuh & Tung 1997; Espada & Barreiro 1999; Zuo & Wang 2007), methods based on theory of input/output stability (Kandel, LUO et al. 1999), conicity criterion (Cuesta & Ollero 2004). Also there are methods based on hyper-stability theory (Piegat 1997) and linguistic stability analysis approach (Gang & Laijiu 1996).