Miracle-dz/UniFAR-FTUs huggingface dataset:
Improvement in Silicon on Insulator Devices using Strained Si/SiGe Technology for High Performance in RF Integrated Circuits

RF performance of SOI CMOS device has attracted significant amount of interest recently. In order to improve RF parameters, Strained Si/Relaxed Si0.8Ge0. 2 investigated as a replacement for Si technology . Enhancement of carrier mobility associated with strain engineering makes Strained Si a promising candidate for improving RF performance of CMOS technology. From the simulation, the cut-off frequency is estimated to be 224 GHZ, whereas in SOI at similar bias is about 188 GHZ. Therefore, Strained Si exhibits 19% improvement in cut-off frequency over similar Si counterpart. In this paper, Ion/Ioff ratio is studied as one of the key parameters in logic and digital application. Strained Si/SiGe demonstrates better Ion/Ioff characteristic than SOI, in similar channel length of 100 nm.Another important key analog figures of merit such as Early Voltage (VEA) ,transconductance vs drain current (gm /Ids) are studied. They introduce the efficiency of the devices to convert dc power into ac frequency. Keywords—cut-off frequency, RF application, Silicon on insulator, Strained Si/SiGe on insulator.
SysProf: Online Distributed Behavior Diagnosis through Fine-grain System Monitoring

Runtime monitoring is key to the effective management of enterprise and high performance applications. To deal with the complex behaviors of today’s multi-tier applications running across shared platforms, such monitoring must meet three criteria: (1) fine granularity, including being able to track the resource usage of specific application behaviors like individual client-server interactions, (2) real-time response, referring to the monitoring system’s ability to both capture and analyze currently needed monitoring information with the delays required for online management, and (3) enterprise-wide operation, which means that the monitoring information captured and analyzed must span across the entire software stack and set of machines involved in request generation, request forwarding, service provision, and return. This paper presents the SysProf system-level monitoring toolkit, which provides a flexible, low overhead framework for enterprise-wide monitoring. The toolkit permits the capture of monitoring information at different levels of granularity, ranging from tracking the system-level activities triggered by a single system call, to capturing the client-server interactions associated with certain request classes, to characterizing the server resources consumed by sets of clients or client behaviors. The paper demonstrates the efficacy of SysProf by using it to manage two different enterprise applications: (1) detecting performance bottlenecks in a high performance shared network file service, and (2) enforcing service level agreements in a multi-tier auctioning web site.
Securing a Deployment Pipeline

At the RELENG 2014 Q&A, the question was asked, “What is your greatest concern? ” and the response was “someone subverting our deployment pipeline”. That is the motivation for this paper. We explore what it means to subvert a pipeline and provide several different scenarios of subversion. We then focus on the issue of securing a pipeline. As a result, we provide an engineering process that is based on having trusted components mediate access to sensitive portions of the pipeline from other components, which can remain untrusted. Applying our process to a pipeline we constructed involving Chef, Jenkins, Docker, Github, and AWS, we find that some aspects of our process result in easy to make changes to the pipeline, whereas others are more difficult. Consequently, we have developed a design that hardens the pipeline, although it does not yet completely secure it.
An adversarial environment model for bounded rational agents in zero-sum interactions

Multiagent environments are often not cooperative nor collaborative; in many cases, agents have conflicting interests, leading to adversarial interactions. This paper presents a formal Adversarial Environment model for bounded rational agents operating in a zero-sum environment. In such environments, attempts to use classical utility-based search methods can raise a variety of difficulties (e.g., implicitly modeling the opponent as an omniscient utility maximizer, rather than leveraging a more nuanced, explicit opponent model). We define an Adversarial Environment by describing the mental states of an agent in such an environment. We then present behavioral axioms that are intended to serve as design principles for building such adversarial agents. We explore the application of our approach by analyzing log files of completed Connect-Four games, and present an empirical analysis of the axioms' appropriateness.
Rater bias in the EASI temperament scales: a twin study.

Under trait theory, ratings may be modeled as a function of the temperament of the child and the bias of the rater. Two linear structural equation models are described, one for mutual self- and partner ratings, and one for multiple ratings of related individuals. Application of the first model to EASI temperament data collected from spouses rating each other shows moderate agreement between raters and little rating bias. Spouse pairs agree moderately when rating their twin children, but there is significantly rater bias, with greater bias for monozygotic than for dizygotic twins. MLE's of heritability are approximately . 5 for all temperament scales with no common environmental variance. Results are discussed with reference to trait validity, the person-situation debate, halo effects, and stereotyping. Questionnaire development using ratings on family members permits increased rater agreement and reduced rater bias.
Efficient on-demand topology control for wireless ad hoc networks

Topology control in wireless ad hoc networks has been heavily studied recently. Different geometric topologies were proposed to be used as the underlying network topologies, in order to achieve the sparseness of the communication network or to guarantee the package delivery of specific routing methods. However, most of the proposed topology control algorithms were applied for all nodes in the networks at the initial network startup stage, and the constructed topologies were kept being maintained thereafter. The overhead of topology control at each node at any time is notable, and this affects the performance of the network and wastes energy for each wireless node. This paper seeks to investigate the practices of efficient on-demand topology control protocol for wireless ad hoc networks. In our new protocol, we only apply the specific topology control technique where and when the wireless node needs it. Our simulation confirms that our scheme has better performance than several existing methods.
Spermidine promotes mating and fertilization efficiency in model organisms

Spermidine is a naturally occurring polyamine involved in multiple biological processes, including DNA metabolism, autophagy and aging. Like other polyamines, spermidine is also indispensable for successful reproduction at several stages. However, a direct influence on the actual fertilization process, i.e., the fusion of an oocyte with a spermatocyte, remains uncertain. To explore this possibility, we established the mating process in the yeast Saccharomyces cerevisiae as a model for fertilization in higher eukaryotes. During human fertilization, the sperm capacitates and the acrosome reaction is necessary for penetration of the oocyte. Similarly, sexually active yeasts form a protrusion called “shmoo” as a prerequisite for mating. In this study, we demonstrate that pheromone-induced shmoo formation requires spermidine. In addition, we show that spermidine is essential for mating in yeast as well as for egg fertilization in the nematode Caenorhabditis elegans. In both cases, this occurs independently from autophagy. In synthesis, we identify spermidine as an important mating component in unicellular and multicellular model organisms, supporting an unprecedented evolutionary conservation of the mechanisms governing fertilization-related cellular fusion.
Acute exposure to ultraviolet radiation targets proteins involved in collagen fibrillogenesis

Introduction: Exposure to chronic, low-dose UV irradiation (UVR) can lead to premature ageing of the skin. Understanding which proteins are affected by acute UVR and photo-dynamically produced reactive oxygen species (ROS) could help to inform strategies to delay photoageing. Conventional biochemical analyses can be used to characterize UVR/ROS-induced damage on a protein-by-protein basis and we have previously shown using SDS-PAGE that collagen I and plasma fibronectin are respectively resistant and susceptible to physiological doses of UVR. The aim of this study was to screen a complex proteome for UVR-affected proteins. Methods: This study employed a sensitive mass spectrometry technique (peptide location fingerprinting: PLF) which can identify structure associated differences following trypsin digestion to characterize the impact of UVR exposure on purified collagen I and tissue fibronectin and to identify UVR-susceptible proteins in an ECM-enriched proteome. Results: Using LC/MS-MS and PLF we show that purified mature type-I collagen is resistant to UVR, whereas purified tissue fibronectin is susceptible. UV irradiation of a human dermal fibroblast-deposited ECM-enriched proteome in vitro, followed by LC/MS-MS and PLF analysis revealed two protein cluster groups of UV susceptible proteins involved in i) matrix collagen fibril assembly and ii) protein translation and motor activity. Furthermore, PLF highlighted UV susceptible domains within targeted matrix proteins, suggesting that UV damage of matrix proteins is localized. Discussion: Here we show that PLF can be used to identify protein targets of UVR and that collagen accessory proteins may be key targets in UVR exposed tissues.
The assessment and rehabilitation of prospective memory problems in people with neurological disorders: A review

People with neurological disorders often report difficulty with prospective memory (PM), that is, remembering to do things they had intended to do. This paper briefly reviews the literature regarding the neuropsychology of PM function, concluding that from the clinical perspective, PM is best considered in terms of its separable but interacting mnemonic and executive components. Next, the strengths and limitations in the current clinical assessment of PM, including the assessment of component processes, desktop analogues of PM tasks, and naturalistic PM tasks, are outlined. The evidence base for the rehabilitation of PM is then considered, focusing on retraining PM, using retrospective memory strategies, problem-solving training, and finally, electronic memory aids. It is proposed that further research should focus on establishing the predictive validity of PM assessment, and refining promising rehabilitation techniques.
High Oxygen Partial Pressure Decreases Anemia-induced Heart Rate Increase Equivalent to Transfusion

Background: Anemia is associated with morbidity and mortality and frequently leads to transfusion of erythrocytes. The authors sought to directly compare the effect of high inspired oxygen fraction versus transfusion of erythrocytes on the anemia-induced increased heart rate (HR) in humans undergoing experimental acute isovolemic anemia. Methods: The authors combined HR data from healthy subjects undergoing experimental isovolemic anemia in seven studies performed by the group. HR changes associated with breathing 100% oxygen by nonrebreathing facemask versus transfusion of erythrocytes at their nadir hemoglobin concentration of 5 g/dl were examined. Data were analyzed using a mixed-effects model. Results: HR had an inverse linear relationship to hemoglobin concentration with a mean increase of 3.9 beats per min per gram of hemoglobin (beats/min/g hemoglobin) decrease (95% CI, 3.7–4.1 beats/min/g hemoglobin), P < 0.0001. Return of autologous erythrocytes significantly decreased HR by 5.3 beats/min/g hemoglobin (95% CI, 3.8–6.8 beats/min/g hemoglobin) increase, P < 0.0001. HR at nadir hemoglobin of 5.6 g/dl (95% CI, 5.5–5.7 g/dl) when breathing air (91.4 beats/min; 95% CI, 87.6–95.2 beats/min) was reduced by breathing 100% oxygen (83.0 beats/min; 95% CI, 79.0–87.0 beats/min), P < 0.0001. The HR at hemoglobin 5.6 g/dl when breathing oxygen was equivalent to the HR at hemoglobin 8.9 g/dl when breathing air. Conclusions: High arterial oxygen partial pressure reverses the heart rate response to anemia, probably because of its usability rather than its effect on total oxygen content. The benefit of high arterial oxygen partial pressure has significant potential clinical implications for the acute treatment of anemia and results of transfusion trials.
Impact of Capsid Conformation and Rep-Capsid Interactions on Adeno-Associated Virus Type 2 Genome Packaging

ABSTRACT Single-stranded genomes of adeno-associated virus (AAV) are packaged into preformed capsids. It has been proposed that packaging is initiated by interaction of genome-bound Rep proteins to the capsid, thereby targeting the genome to the portal of encapsidation. Here we describe a panel of mutants with amino acid exchanges in the pores at the fivefold axes of symmetry on AAV2 capsids with reduced packaging and reduced Rep-capsid interaction. Mutation of two threonines at the rim of the fivefold pore nearly completely abolished Rep-capsid interaction and packaging. This suggests a Rep-binding site at the highly conserved amino acids at or close to the pores formed by the capsid protein pentamers. A different mutant (P. Wu, W. Xiao, T. Conlon, J. Hughes, M. Agbandje-McKenna, T. Ferkol, T. Flotte, and N. Muzyczka, J. Virol. 74:8635-8647, 2000) with an amino acid exchange at the interface of capsid protein pentamers led to a complete block of DNA encapsidation. Analysis of the capsid conformation of this mutant revealed that the pores at the fivefold axes were occupied by VP1/VP2 N termini, thereby preventing DNA introduction into the capsid. Nevertheless, the corresponding capsids had more Rep proteins bound than wild-type AAV, showing that correct Rep interaction with the capsid depends on a defined capsid conformation. Both mutant types together support the conclusion that the pores at the fivefold symmetry axes are involved in genome packaging and that capsid conformation-dependent Rep-capsid interactions play an essential role in the packaging process.
Dermal regeneration in full‐thickness wounds in Yucatan miniature pigs using a biodegradable copolymer

The aim of this study was to assess the performance of a biodegradable dermal substrate in deep dermal skin defects. The substrate consisted of a synthetic biodegradable matrix called Polyactive, which is an elastomeric poly (ether)/poly (ester) block copolymer. This matrix was manufactured either as a porous substrate, with gradually changing pore size (BISKIN‐M), or as a bilayer consisting of a porous underlayer with a fully dense surface layer (BISKIN). Cell‐free matrices and matrices seeded with autologous or allogeneic porcine fibroblasts were applied to full‐thickness skin wounds in Yucatan miniature pigs. Biopsies were taken at different time intervals up to 24‐months post‐transplantation. Although all BISKIN substrates showed little or no adherence to the wound bed, the adherence of the BISKIN‐M substrates to the underlying wound was achieved within minutes after application. Therefore, only BISKIN‐M Polyactive substrates were further evaluated. Wound contraction was inhibited by both cell‐free and fibroblast‐populated substrates. All substrates showed extensive neovascular and fibrous tissue ingrowth within 2‐weeks post‐transplantation. Furthermore, during this time period, matrix degradation was observed, starting with the fragmentation of the polymers into particles, which were phagocytized by macrophages. These processes occurred actively up to 3 months and ceased thereafter. Cell‐free substrates degraded faster, and also, the collagen deposition was lower as compared with cell‐seeded substrates. The tissue surrounding the remnants of the Polyactive substrates after 24‐months post‐transplantation consisted of a mature connective tissue. The newly formed collagen had the same distribution pattern as observed in normal native dermis. We conclude therefore that treatment of full‐thickness skin defects with fibroblast‐populated BISKIN‐M Polyactive substrates leads to satisfactory dermal regeneration.
Relationships Between Lyrics and Melody in Popular Music

Composers of popular music weave lyrics, melody, and instrumentation together to create a consistent and compelling emotional scene. The relationships among these elements are critical to musical communication, and understanding the statistics behind these relationships can contribute to numerous problems in music information retrieval and creativity support. In this paper, we present the results of an observational study on a large symbolic database of popular music; our results identify several patterns in the relationship between lyrics and melody.
NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis

Background The NLR family, pyrin domain containing 3 (NLRP3) inflammasome is an interleukin (IL)‐1β and IL‐18 cytokine processing complex that is activated in inflammatory conditions. The role of the NLRP3 inflammasome in the pathogenesis of atherosclerosis and myocardial infarction is not fully understood. Methods and Results Atherosclerotic plaques were analyzed for transcripts of the NLRP3 inflammasome, and for IL‐1β release. The Swedish First‐ever myocardial Infarction study in Ac‐county (FIA) cohort consisting of DNA from 555 myocardial infarction patients and 1016 healthy individuals was used to determine the frequency of 4 single nucleotide polymorphisms (SNPs) from the downstream regulatory region of NLRP3. Expression of NLRP3, Apoptosis‐associated speck‐like protein containing a CARD (ASC), caspase‐1 (CASP1), IL1B, and IL18 mRNA was significantly increased in atherosclerotic plaques compared to normal arteries. The expression of NLRP3 mRNA was significantly higher in plaques of symptomatic patients when compared to asymptomatic ones. CD68‐positive macrophages were observed in the same areas of atherosclerotic lesions as NLRP3 and ASC expression. Occasionally, expression of NLRP3 and ASC was also present in smooth muscle cells. Cholesterol crystals and ATP induced IL‐1β release from lipopolysaccharide‐primed human atherosclerotic lesion plaques. The minor alleles of the variants rs4266924, rs6672995, and rs10733113 were associated with NLRP3 mRNA levels in peripheral blood mononuclear cells but not with the risk of myocardial infarction. Conclusions Our results indicate a possible role of the NLRP3 inflammasome and its genetic variants in the pathogenesis of atherosclerosis.
Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene

The adenomatous polyposis coli (APC) gene is a key tumor suppressor gene. Mutations in the gene have been found not only in most colon cancers but also in some other cancers, such as those of the liver. The APC gene product is a 312 kDa protein that has multiple domains, through which it binds to various proteins, including β-catenin, axin, CtBP, Asefs, IQGAP1, EB1 and microtubules. Studies using mutant mice and cultured cells have demonstrated that APC suppresses canonical Wnt signalling, which is essential for tumorigenesis, development and homeostasis of a variety of cell types, such as epithelial and lymphoid cells. Further studies have suggested that APC plays roles in several other fundamental cellular processes. These include cell adhesion and migration, organization of the actin and microtubule networks, spindle formation and chromosome segregation. Deregulation of these processes caused by mutations in APC is implicated in the initiation and expansion of colon cancer.
Simulation and Optimization of Surface Roughness and Process Performance during Machining of HSS by Micro-WEDM Technology

When machining high-speed steels (HSS) with micro-wire electrical discharge machining (micro-WEDM), high surface quality is achieved as standard. The value of the roughness parameter Ra is less than 0.2 μm. However, the problem is the performance of the electroerosion process (MRR), which is low. This problem is related to the mechanical and physical properties of the HSS in combination with the setting of the main technological parameters (MTP). The proposed solution to eliminate this problem relies on the selection of proper procedures for the determination of optimization criteria in relation to Ra and MTP, with the inclusion of properties of the machined material. The solution consisted in the identification of four significant physical (ρ, κ) and mechanical (Rm, HRC) indicators of HSS properties, on the basis of which a suitable combination of the process output parameters Ra and MRR can be determined through established mathematical regression models using simulation and optimization. In the next step, the proper values of the MTP output process parameter settings, which correspond to the optimized output parameters Ra and MRR during machining of HSS by micro-WEDM technology, were then obtained by the same approach.
Diffusion Processes Invalidating the Intra‐arterial Krypton‐85 Beta‐Particle Clearance Method for Measurement of Skin Blood Flow in Man

Krypton-85 dissolved in 0.9% NaCl was injected into the femoral artery of man; β particles were measured over the skin of the crus. Cutaneous mean blood flow was calculated using the integral equation of Zierler based on the mean transit time analysis of clearance curves recorded from the cutaneous tissue; these calculations gave estimates which were only about one-fifth those obtained by other methods. The low estimates were caused by an intercom-partmental exchange of 85krypton between the cutaneous and subcutaneous tissues, an exchange implying that both tissues influence the shape of the clearance curve recorded from the cutaneous tissue alone. This intercompart-mental exchange was effected not only by diffusion directly from the cutaneous to the subcutaneous tissue, but presumably also by transport from the blood streaming between the two tissues. The clearance rate of the tail of the curve was shown to correspond to that of the subcutaneous tissue. The errors distorting the clearance curve of β particles may invalidate the use of intra-arterial injection and measurement of clearance curves of β particles for measurement of blood flow in other tissues.
Multiresolution Surface Modeling Based on Hierarchical Triangulation 1

modeling technique. The initial model consists in a surface ample, the resulting model should be defined in an objecttriangulation resulting from the integration of a set of range centered reference frame and non-uniform sampling of views. Thereafter, a hierarchical triangulation algorithm iterathe object surface should be allowed. For triangle-based tively removes vertices of the triangulation, always minimizing representations, the surface triangulations should be equithe retriangulation error. The equiangularity of the surface angular in 3-D space in order to increase the upper bound triangulation is optimized in 3-D space throughout the optimion the curvature of sampled surfaces. Finally, the algorithm zation process. Besides compressing surface information, the should preserve the topology of the object as well as the proposed technique preserves the topology of the triangulation surface orientation discontinuities. Few of the previously and surface orientation discontinuities. Experimental models reported multiresolution techniques possess all these propbuilt from complex multipart objects with holes are pre-