Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of Different Feature Extraction Methods on Classification of Gene Expression Data

It is important to extract the most relevant features of the genetic profiles to determine the health condition of the cellular structure. Early diagnosis of the illnesses has a great importance in the treatment. In this study, we analyzed a gene expression data by classifying using support vector machines after applying different feature extraction methods as principal component analysis (PCA) and independent component analysis (ICA). Results have been compared with the results of the feature extraction algorithm based on genetic algorithm (GA).
Intracellular Calcium Dynamics and Anisotropic Reentry in Isolated Canine Pulmonary Veins and Left Atrium

Background—Rapid activations due to either focal discharge or reentry are often present during atrial fibrillation (AF) in the pulmonary veins (PVs). The mechanisms of these rapid activations are unclear. Methods and Results—We studied 7 isolated, Langendorff-perfused canine left atrial (LA) and PV preparations and used 2 cameras to map membrane potential alone (Vm, n=3) or Vm and intracellular calcium simultaneously (Cai, n=4). Rapid atrial pacing induced 26 episodes of focal discharge from the proximal PVs in 5 dogs. The cycle lengths were 223±52 ms during ryanodine infusion (n=13) and 133±59 ms during ryanodine plus isoproterenol infusion (n=13). The rise of Cai preceded Vm activation at the sites of focal discharge in 6 episodes of 2 preparations, compatible with voltage-independent spontaneous Cai release. Phase singularities during pacing-induced reentry clustered specifically at the PV-LA junction. Periodic acid–Schiff (PAS) stain identified large cells with pale cytoplasm along the endocardium of PV muscle sleeves. There were abrupt changes in myocardial fiber orientation and increased interstitial fibrosis in the PV and at the PV-LA junction. Conclusions—PV muscle sleeves may develop voltage-independent Cai release, resulting in focal discharge. Focal discharge may also be facilitated by the presence of PAS-positive cells that are compatible with node-like cells. During reentry, phase singularities clustered preferentially at sites of increased anisotropy such as the PV-LA junction. These findings suggest that focal discharge caused by spontaneous calcium release and anisotropic reentry both contribute to rapid activations in the PVs during AF.
Recipient Age and Mortality Risk after Liver Transplantation: A Population-Based Cohort Study

The aim of the present large population-based cohort study is to explore the risk factors of age-related mortality in liver transplant recipients in Taiwan. Basic information and data on medical comorbidities for 2938 patients who received liver transplants between July 1, 1998, and December 31, 2012, were extracted from the National Health Insurance Research Database on the basis of ICD-9-codes. Mortality risks were analyzed after adjusting for preoperative comorbidities and compared among age cohorts. All patients were followed up until the study endpoint or death. This study finally included 2588 adults and 350 children [2068 (70.4%) male and 870 (29.6%) female patients]. The median age at transplantation was 52 (interquartile range, 43–58) years. Recipients were categorized into the following age cohorts: <20 (n = 350, 11.9%), 20–39 (n = 254, 8.6%), 40–59 (n = 1860, 63.3%), and ≥60 (n = 474, 16.1%) years. In the total population, 428 deaths occurred after liver transplantation, and the median follow-up period was 2.85 years (interquartile range, 1.2–5.5 years). Dialysis patients showed the highest risk of mortality irrespective of age. Further, the risk of death increased with an increase in the age at transplantation. Older liver transplant recipients (≥60 years), especially dialysis patients, have a higher mortality rate, possibly because they have more medical comorbidities. Our findings should make clinicians aware of the need for better risk stratification among elderly liver transplantation candidates.
The risk of dementia with increased body mass index.

BACKGROUND identification of modifiable risk factors is crucial in the prevention of dementia, given its limited treatment options. Studies on increased body mass index (BMI) as a risk factor for dementia show conflicting results. METHODS we systematically retrieved and reviewed longitudinal population-based studies on increased BMI and dementia using a standard protocol. We searched Medline (1966-2006), Ageline (1978-2006), PsychInfo (1966-2006), CINAHL (1982-2006), and other relevant databases, including the reference lists of the eligible articles for review. Included studies were subjected to a quality assessment protocol. RESULTS we identified eight studies that met our selection criteria. These studies covered 1,688 cases of dementia from 28,697 participants. After adjustment for age, smoking, comorbidities, and other confounders, four studies presented significantly increased risk of dementia with elevated BMI. CONCLUSION this systematic review supports the hypothesis that increased BMI is independently associated with increased risk of dementia. Long-term studies to examine the mechanisms underlying the relationship between obesity and dementia are needed.
A 3.1–10.6 GHz Ultra-Wideband CMOS Low Noise Amplifier With Current-Reused Technique

A 3.1-10.6 GHz ultra-wideband (UWB) low noise amplifier (LNA) utilizing a current-reused technique and a simple high-pass input matching network is proposed. The implemented LNA presents a maximum power gain of 16dB, and a good input matching of 50Omega in the required band. An excellent noise figure (NF) of 3.1-6dB was obtained in the frequency range of 3.1-10.6GHz with a power dissipation of 11.9mW under a 1.8-V power supply. The proposed UWB LNA demonstrates the highest power gain and lowest NF among the published works in 0.18-mum CMOS technology
Der Open-access-publikationsserver Der Zbw – Leibniz-informationszentrum Wirtschaft the Open Access Publication Server of the Zbw – Leibniz Information Centre for Economics Not Invented Here: Technology Licensing, Knowledge Transfer and Innovation Based on Public Research Not Invented Here: Technolo

Terms of use: The ZBW grants you, the user, the non-exclusive right to use the selected work free of charge, territorially unrestricted and within the time limit of the term of the property rights according to the terms specified at → http://www.econstor. eu/dspace/Nutzungsbedingungen By the first use of the selected work the user agrees and declares to comply with these terms of use. Abstract: Using a new dataset encompassing more than 2,200 inventions made by Max Planck Society researchers from 1980 to 2004, we explore how licensee and technology characteristics affect the licensing and commercialization of technologies from public research. We find no evidence that spin-offs and external licensees systematically differ in their likelihood of successful commercialization. Technologies licensed to foreign firms are less often commercialized, which may reflect selection effects. Patented technologies and inventions by senior scientists are more likely to be licensed, but patent protection is related to lower commercialization odds and lower royalty payments.
Joint Beamforming and Power Splitting for MISO Interference Channel With SWIPT: An SOCP Relaxation and Decentralized Algorithm

This paper considers a power splitting-based MISO interference channel for simultaneous wireless information and power transfer (SWIPT), where each single antenna receiver splits the received signal into two streams of different power for decoding information and harvesting energy separately. We aim to minimize the total transmission power by joint beamforming and power splitting (JBPS) under both the signal-to-interference-plus-noise ratio (SINR) constraints and energy harvesting (EH) constraints. The JBPS problem is nonconvex and has not yet been well addressed in the literature. Moreover, decentralized algorithm design for JBPS based on local channel state information (CSI) and limited information exchange remains open. In this paper, we first propose a novel relaxation method named second-order cone programming (SOCP) relaxation to address the JBPS problem. We formulate the relaxed problem as an SOCP and present two sufficient conditions under which the SOCP relaxation is tight. For the case when the SOCP solution is not necessarily optimal to the JBPS problem, a closed-form feasible-solution-recovery method is provided. Then, we develop a distributed algorithm for the JBPS problem based on primal-decomposition (PD) method. The PD-based distributed algorithm consists of a master problem and a set of subproblems. The former is solved by using subgradient method while the latter are solved using coordinate descent method. Finally, numerical results validates the efficiency of the proposed algorithms.
Growth factors and myometrium: biological effects in uterine fibroid and possible clinical implications.

BACKGROUND Growth factors are proteins secreted by a number of cell types that are capable of modulating cellular growth, proliferation and cellular differentiation. It is well accepted that uterine cellular events such as proliferation and differentiation are regulated by sex steroids and their actions in target tissues are mediated by local production of growth factors acting through paracrine and/or autocrine mechanisms. Myometrial mass is ultimately modified in pregnancy as well as in tumour conditions such as leiomyoma and leiomyosarcoma. Leiomyomas, also known as fibroids, are benign tumours of the uterus, considered to be one of the most frequent causes of infertility in reproductive years in women. METHODS For this review, we searched the database MEDLINE and Google Scholar for articles with content related to growth factors acting on myometrium; the findings are hereby reviewed and discussed. RESULTS Different growth factors such as epidermal growth factor (EGF), transforming growth factor-α (TGF-α), heparin-binding EGF (HB-EGF), acidic fibroblast growth factor (aFGF), basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), platelet-derived growth factor (PDGF) and TGF-β perform actions in myometrium and in leiomyomas. In addition to these growth factors, activin and myostatin have been recently identified in myometrium and leiomyoma. CONCLUSIONS Growth factors play an important role in the mechanisms involved in myometrial patho-physiology.
Diophantine approximation by orbits of expanding Markov maps

Abstract In 1995, Hill and Velani introduced the ‘shrinking targets’ theory. Given a dynamical system ([0,1],T), they investigated the Hausdorff dimension of sets of points whose orbits are close to some fixed point. In this paper, we study the sets of points well approximated by orbits {Tnx}n≥0, where Tis an expanding Markov map with a finite partition supported by [0,1]. The dimensions of these sets are described using the multifractal properties of invariant Gibbs measures.
Human and constructive proof of combinatorial identities: an example from Romik

It has become customary to prove binomial identities by means of the method for automated proofs as developed by Petkovsek, Wilf and Zeilberger. In this paper, we wish to emphasize the role of "human'' and constructive proofs in contrast with the somewhat lazy attitude of relaying on "automated'' proofs. As a meaningful example, we consider the four formulas by Romik, related to Motzkin and central trinomial numbers. We show that a proof of these identities can be obtained by using the method of coefficients, a human method only requiring hand computations.
Promotion of Remyelination by Sulfasalazine in a Transgenic Zebrafish Model of Demyelination

Most of the axons in the vertebrate nervous system are surrounded by a lipid-rich membrane called myelin, which promotes rapid conduction of nerve impulses and protects the axon from being damaged. Multiple sclerosis (MS) is a chronic demyelinating disease of the CNS characterized by infiltration of immune cells and progressive damage to myelin and axons. One potential way to treat MS is to enhance the endogenous remyelination process, but at present there are no available treatments to promote remyelination in patients with demyelinating diseases. Sulfasalazine is an anti-inflammatory and immune-modulating drug that is used in rheumatology and inflammatory bowel disease. Its anti-inflammatory and immunomodulatory properties prompted us to test the ability of sulfasalazine to promote remyelination. In this study, we found that sulfasalazine promotes remyelination in the CNS of a transgenic zebrafish model of NTR/MTZ-induced demyelination. We also found that sulfasalazine treatment reduced the number of macrophages/microglia in the CNS of demyelinated zebrafish larvae, suggesting that the acceleration of remyelination is mediated by the immunomodulatory function of sulfasalazine. Our data suggest that temporal modulation of the immune response by sulfasalazine can be used to overcome MS by enhancing myelin repair and remyelination in the CNS.
Apelin-APJ Signaling: a Potential Therapeutic Target for Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is a progressive disease characterized by the vascular remodeling of the pulmonary arterioles, including formation of plexiform and concentric lesions comprised of proliferative vascular cells. Clinically, PAH leads to increased pulmonary arterial pressure and subsequent right ventricular failure. Existing therapies have improved the outcome but mortality still remains exceedingly high. There is emerging evidence that the seven-transmembrane G-protein coupled receptor APJ and its cognate endogenous ligand apelin are important in the maintenance of pulmonary vascular homeostasis through the targeting of critical mediators, such as Krűppel-like factor 2 (KLF2), endothelial nitric oxide synthase (eNOS), and microRNAs (miRNAs). Disruption of this pathway plays a major part in the pathogenesis of PAH. Given its role in the maintenance of pulmonary vascular homeostasis, the apelin-APJ pathway is a potential target for PAH therapy. This review highlights the current state in the understanding of the apelin-APJ axis related to PAH and discusses the therapeutic potential of this signaling pathway as a novel paradigm of PAH therapy.
Search for Gamma-Ray Burst Classes with the RHESSI Satellite

A sample of 427 gamma-ray bursts (GRBs), measured by the RHESSI satellite, is studied statistically with respect to duration and hardness ratio. Standard statistical tests are used, such as $\chi^2$, F-test and the maximum likelihood ratio test, in order to compare the number of GRB groups in the RHESSI database with that of the BATSE database. Previous studies based on the BATSE Catalog claim the existence of an intermediate GRB group, besides the long and short groups. Using only the GRB duration $T_{90}$ as information and $\chi^2$ or F-test, we have not found any statistically significant intermediate group in the RHESSI data. However, maximum likelihood ratio test reveals a significant intermediate group. Also using the 2-dimensional hardness / $T_{90}$ plane, the maximum likelihood analysis reveals a significant intermediate group. Contrary to the BATSE database, the intermediate group in the RHESSI data-set is harder than the long one. The existence of an intermediate group follows not only from the BATSE data-set, but also from the RHESSI one.
Error resilient concurrent video streaming over wireless mesh networks

In this paper, we propose a multi-source multi-path video streaming system for supporting high quality concurrent video-on-demand (VoD) services over wireless mesh networks (WMNs), and leverage forward error correction to enhance the error resilience of the system. By taking wireless interference into consideration, we present a more realistic networking model to capture the characteristics of WMNs and then design a route selection scheme using a joint rate/interference-distortion optimization framework to help the system optimally select concurrent streaming paths. We mathematically formulate such a route selection problem, and solve it heuristically using genetic algorithm. Simulation results demonstrate the effectiveness of our proposed scheme.
Error Analysis of Hybrid DS-Multiband-UWB Multiple Access System in the Presence of Narrowband Interference

This paper proposes a hybrid multiband (MB) ultra wideband (UWB) system with direct sequence (DS) spreading. The theoretical error analysis for the DS-MB-UWB multiple access system with Rake receiver in the presence of multipath and narrowband interference is developed. The developed theoretical framework models the multiple access interference (MAI), multipath interference (MI) and narrowband interference for the designed UWB system. It is shown that the system error performance corresponding to the combining effects of these interference can be accurately modeled and calculated. Monte Carlo simulation results are provided to validate the accuracy of the model. Additionally, it is found that narrowband interference can be mitigated effectively in the multiband UWB system by suppressing the particular UWB sub-band co-existing with the interfering narrowband signal. A typical improvement of 5dB can be achieved with 75% sub-band power suppression. On the other hand, suppression of UWB sub-band is also found to decrease frequency diversity, thus facilitating the increase of MAI. In this paper, the developed model is utilized to determine the parameters that optimize the UWB system performance by minimizing the effective interference.
Combined EGFR and VEGFR versus Single EGFR Signaling Pathways Inhibition Therapy for NSCLC: A Systematic Review and Meta-Analysis

Background Lung cancer is a heterogeneous disease with multiple signaling pathways influencing tumor cell survival and proliferation, and it is likely that blocking only one of these pathways allows others to act as salvage or escape mechanisms for cancer cells. Whether combined inhibition therapy has greater anti-tumor activity than single inhibition therapy is a matter of debate. Hence, a meta-analysis comparing therapy inhibiting both VEGFR and EGFR signaling pathways with that inhibiting EGFR signaling pathway alone was performed. Methodology and Principal Findings We searched PubMed, EMBASE database and the proceedings of major conferences for relevant clinical trials. Outcomes analyzed were objective tumor response rate (ORR), progression-free survival (PFS), overall survival (OS) and toxicity. Besides, subgroup analyses were performed to investigate whether the combined inhibition therapy is best performed using combination of selective agents or a single agent with multiple targets. Six trials recruiting 3,302 patients were included in the analysis. Combined inhibition therapy was associated with a 3% improvement in OS as compared with single-targeted therapy, but this difference was not statistically significant (HR, 0.97; 95% CI, 0.89–1.05; P = 0.472). Patients receiving combined inhibition therapy had significant longer PFS than the group with single-targeted therapy (HR, 0.80; 95% CI, 0.67–0.95; P = 0.011). There was no difference in the ORR between the groups (OR, 1.44; 95% CI, 0.95–2.18; P = 0.085). Subgroup analysis revealed that combined inhibition therapy using combination regimens was associated with statistically significant improvement in both ORR and PFS. Toxicity was greater in combined inhibition therapy. Conclusions There is no evidence to support the use of combined inhibition therapy in unselected patients with advanced NSCLC. However, given the significant advantage in ORR and PFS, combined inhibition therapy using combination regimens may be considered for further evaluation in subsets of patients who may benefit from this treatment.
Rotavirus capsid VP6 protein acts as an adjuvant in vivo for norovirus virus-like particles in a combination vaccine

ABSTRACT Rotavirus (RV) and norovirus (NoV) are the 2 leading causes of acute viral gastroenteritis worldwide. We have developed a non-live NoV and RV vaccine candidate consisting of NoV virus-like particles (VLPs) and recombinant polymeric RV VP6 protein produced in baculovirus-insect cell expression system. Both components have been shown to induce strong potentially protective immune responses. As VP6 nanotubes are highly immunogenic, we investigated here a possible adjuvant effect of these structures on NoV-specific immune responses in vivo. BALB/c mice were immunized intramuscularly with a suboptimal dose (0.3 μg) of GII.4 or GI.3 VLPs either alone or in a combination with 10 μg dose of VP6 and induction of NoV-specific antibodies in sera of experimental animals were measured. Blocking assay using human saliva or synthetic histo-blood group antigens was employed to test NoV blocking antibodies. Suboptimal doses of the VLPs alone did not induce substantial anti-NoV antibodies. When co-administered with the VP6, considerable titers of not only type-specific but also cross-reactive IgG antibodies against NoV VLP genotypes not included in the vaccine composition were induced. Most importantly, NoV-specific blocking antibodies, a surrogate for neutralizing antibodies, were generated. Our results show that RV VP6 protein has an in vivo adjuvant effect on NoV-specific antibody responses and support the use of VP6 protein as a part of the NoV-RV combination vaccine, especially when addition of external adjuvants is not desirable.
Risk analysis of online social networks

Social networks are used as the communication network among the groups of people. In past few years several fields use the structure of social network and utilize it. But there are many threats and challenges associated with these networks. These threats disclose the personal information of the users and use that information for unauthorized and malicious purposes. One of the great revolutions in the field of online social networking is online health social network, which is a sub branch of ordinary social network. OHSNs are used for enhancement in the field of health care issues and improvise the better solution for those issues. In this paper we discuss security issues and privacy risk which harm the online social network user. In addition we survey the existing defense mechanism and also propose the better protection and security ideas for online social network users. Furthermore we advise future research directions.