Miracle-dz/UniFAR-FTUs huggingface dataset:
Gender Differences in Internet Use Patterns and Internet Application Preferences: A Two-Sample Comparison

Although the Internet frequently has been characterized as male-dominated, recent evidence indicates that the gender gap in Internet use is rapidly diminishing. If more females are using the Internet, then what specific applications do they prefer and do they differ from those of males? This article presents results from a survey assessing gender differences in specific uses of the Internet. The survey included 19 items and was made available to Internet users. For comparison, a paper-and-pencil version was administered to several hundred introductory psychology students. Numerous gender differences in preferences for specific Internet applications emerged. Results showed that males use the Internet mainly for purposes related to entertainment and leisure, whereas women use it primarily for interpersonal communication and educational assistance. However, additional analyses showed that several gender differences were mediated by differences in age and Internet experience. Potential implications of these r.
Correlates of Prescription Opioid Initiation and Long-term Opioid Use in Veterans With Persistent Pain

Objectives:Little is known about how opioid prescriptions for chronic pain are initiated. We sought to describe patterns of prescription opioid initiation, identify correlates of opioid initiation, and examine correlates of receipt of chronic opioid therapy (COT) among veterans with persistent noncancer pain. Methods:Using Veterans Affairs administrative data, we identified 5961 veterans from the Pacific Northwest with persistent elevated pain intensity scores who had not been prescribed opioids in the prior 12 months. We compared veterans not prescribed opioids over the subsequent 12 months with those prescribed any opioid and to those prescribed COT (>90 consecutive days). Results:During the study year, 35% of the sample received an opioid prescription and 5% received COT. Most first opioid prescriptions were written by primary care clinicians. Veterans prescribed COT were younger, had greater pain intensity, and high rates of psychiatric and substance use disorders compared with veterans in the other 2 groups. Among patients receiving COT, 29% were prescribed long-acting opioids, 37% received 1 or more urine drug screens, and 24% were prescribed benzodiazepines. Adjusting for age, sex, and baseline pain intensity, major depression [odds ratio 1.24 (1.10-1.39); 1.48 (1.14-1.93)], and nicotine dependence [1.34 (1.17-1.53); 2.02 (1.53-2.67)] were associated with receiving any opioid prescription and with COT, respectively. Discussion:Opioid initiations are common among veterans with persistent pain, but most veterans are not prescribed opioids long-term. Psychiatric disorders and substance use disorders are associated with receiving COT. Many Veterans receiving COT are concurrently prescribed benzodiazepines and many do not receive urine drug screening; additional study regarding practices that optimize safety of COT in this population is indicated.
Automatic Music Mood Classification of Hindi Songs

The popularity of internet, downloading and purchasing music from online music shops are growing dramatically. As an intimate relationship presents between music and human emotions, we often choose to listen a song that suits our mood at that instant. Thus, the automatic methods are needed to classify music by moods even from the uploaded music files in social networks. However, several studies on Music Information Retrieval (MIR) have been carried out in recent decades. In the present task, we have built a system for classifying moods of Hindi songs using different audio related features like rhythm, timber and intensity. Our dataset is composed of 230 Hindi music clips of 30 seconds that consist of five mood clusters. We have achieved an average accuracy of 51.56% for music mood classification on the above data.
Technical Perspective: Jupiter rising

the lessons and process described in this paper to be more widely applicable for those outside the arena of the hy-per-scale datacenter architect. Some solutions may be a confluence of circumstance. Opportunity is created by a measurement-derived understanding of traffic growth and a lack of any practical vendor. Keen to strip any solution of unnecessary features, the availability of cheap commodity (merchant) silicon and a software-centered network-control plane leads to a scal-able, bespoke, network design. Migration from old systems to new would incur mammoth challenges for a single deployment or upgrade and yet the authors describe rolling a deployment five times between 2004 and 2012, all while also limiting the impact to services. Successive network implementations are tangibly improved by this experience. The reader is presented with other operational insights including how to achieve practical scaling by focus-ing upon an architecture designed in sympathy with their datacenter peculiarities. An example of this is how the design of a robust distributed system, the switch-fabric management itself, can be balanced against the benefit of a centralization of control. The authors illustrate how a centralized approach need not discard distributed advantages, an idea that is core for many scale-out designs. In turn, this provides a facility or mechanism using the resources of multiple machines all while coping with the failures inherent in any large design. As datacenter services are central in all our lives, I commend " Jupiter Rising " to you. While the paper is steeped in operational experience it is far beyond a simple anecdote-ridden history tale; the authors describe solutions with the unique confluence of need, ability, and circumstances transposed into a fascinating set of insights for the reader. DESPITE ALL OF us regularly reading of the growth of the Internet, whether it be capacity , number of users, or breadth of applications, beyond the proliferation, and ever-shortening upgrade cycle of our mobile phones, we rarely observe a physical manifestation of such growth. Yet, it is within warehouse-sized computer facilities, the datacenters that attract the superlative hyper, that the Internet growth is physically manifest. Not only must these facilities face operational challenges arising from a large and dynamic number of users, but the continuous growth in demand upon these facilities must also be accommodated. Such growth for the hyper-scale datacenter translates to a modest-sized facility covering 15 acres, housing over 200,000 servers, consuming mega-gallons of water and perhaps hundreds of …
Understanding Anatomy Classification Through Visualization

One of the main challenges for broad adoption of deep convolutional neural network (DCNN) models is the lack of understanding of their decision process. In many applications a simpler less capable model that can be easily understood is favorable to a black-box model that has superior performance. In this paper, we present an approach for designing DCNN models based on visualization of the internal activations of the model. We visualize the model's response using fractional stride convolution technique and compare the results with known imaging landmarks from the medical literature. We show that sufficiently deep and capable models can be successfully trained to use the same medical landmarks a human expert would use. The presented approach allows for communicating the model decision process well, but also offers insight towards detecting biases.
Device-Free Passive Human Detection Using Wi-Fi Technology: Current State and Future Trend

Wireless LANs using Wi-Fi technology are now very common in indoor environments, making it unprecedentedly convenient and low-cost for users accessing digital services on the Internet. Wi-Fi signals are typically information carriers between a transmitter and a receiver, lots of signal features can be extracted from measurements of the transmitted signals to develop numerous innovative applications. Focusing on device-free passive detection using Wi-Fi technology, in this paper, we provide a review of existing works that were done for detecting human motion indoor by classifying these research efforts into three categories according to the used wireless signal features. Specifically, we first describe the Wi-Fi signal features that are frequently used for device-free detection of human mobility in indoor environments, including RSSI, CSI and TOF. We then separate existing work into three categories according to these wireless signal features. A set of potential applications that can be developed within this new open research area of device-free passive human mobility detection will be proposed. Finally, we will discuss existing research challenges and point out possible research directions.
Significance of Interactions of Low Molecular Weight Crystallin Fragments in Lens Aging and Cataract Formation*

Analysis of aged and cataract lenses shows the presence of increased amounts of crystallin fragments in the high molecular weight aggregates of water-soluble and water-insoluble fractions. However, the significance of accumulation and interaction of low molecular weight crystallin fragments in aging and cataract development is not clearly understood. In this study, 23 low molecular mass (<3.5-kDa) peptides in the urea-soluble fractions of young, aged, and aged cataract human lenses were identified by mass spectroscopy. Two peptides, αB-(1–18) (MDIAIHHPWIRRPFFPFH) and βA3/A1-(59–74) (SD(N)AYHIERLMSFRPIC), present in aged and cataract lens but not young lens, and a third peptide, γS-(167–178) (SPAVQSFRRIVE) present in all three lens groups were synthesized to study the effects of interaction of these peptides with intact α-, β-, and γ-crystallins and alcohol dehydrogenase, a protein used in aggregation studies. Interaction of αB-(1–18) and βA3/A1-(59–74) peptides increased the scattering of light by β- and γ-crystallin and alcohol dehydrogenase. The ability of α-crystallin subunits to function as molecular chaperones was significantly reduced by interaction with αB-(1–18) and βA3/A1-(59–74) peptides, whereas γS peptide had no effect on chaperone-like activity of α-crystallin. The βA3/A1-(59–74 peptide caused a 5.64-fold increase in αB-crystallin oligomeric mass and partial precipitation. Replacing hydrophobic residues in αB-(1–18) and βA3/A1-(59–74) peptides abolished their ability to induce crystallin aggregation and light scattering. Our study suggests that interaction of crystallin-derived peptides with intact crystallins could be a key event in age-related protein aggregation in lens and cataractogenesis.
Autistic spectrum disorders

Autism seems to be on the increase. This at least is the feeling of many professionals in the field of child development in Britain, who believe that in recent years they have been seeing more children with autistic spectrum disorders. Autism was first characterised in 1943 by Kanner,1 who described a group of children with an unusual pattern of behaviour present from birth or before 30 months. He called this “early infantile autism. ” His essential criteria for diagnosis were social aloofness and elaborate repetitive routines.2 Subsequent epidemiological studies have shown that autism is not, as Kanner first thought, a unique and separate condition occurring in children of otherwise normal development but that it is closely related to a range of developmental disorders.3 4 These include Asperger's syndrome,5 a condition characterised by borderline or normal IQ; social isolation or naive, inappropriate social interaction; intensive interest in only one or two subjects; a narrow, repetitive life style; limited or inappropriate intonation and body language; and poor motor coordination. Autistic spectrum disorders share a triad of impaired social interaction, communication, and imagination, associated with a rigid, repetitive pattern of behaviour. Onset is usually at birth or during the first three years of life, but problems can begin later in childhood. The triad can be recognised at all levels of intelligence and can …
Reversible Cytotoxic Edema in a Cirrhotic Patient Following TIPS

The authors report the magnetic resonance imaging (MRI) findings in a 52‐year‐old man with cirrhosis from chronic hepatitis C who developed episodic acute hepatic encephalopathy Type C following placement of transjugular intrahepatic portosystemic shunt (TIPS). Brain MRI revealed hyperintense T2 signal and restricted diffusion distributed through the cerebral cortex. The patient's mentation improved with treatment of his hyperammonemia. Brain MRI performed 5 months later revealed diffuse cerebral atrophy and new areas of hyperintense T2 signal in the cerebral white matter. The cortical signal abnormalities and low apparent diffusion coefficient values on the initial MRI resolved with exception of a mild amount of hyperintense FLAIR signal in the cingulate cortex.
Inflow mapping method for numerical flow simulations of OCT-based patient-specific vessels using CFD

Abstract Alteration of the flow characteristics in coronary vessels is correlated with coronary heart disease (CHD). In particular, wall shear stress (WSS) appears to be a hemody-namic key factor in the genesis of CHD. Since computational fluid dynamics (CFD) is a well-known method for the inves-tigation of WSS, it may be a valuable tool for the prediction of CHD. Latest imaging techniques, such as optical coher-ence tomography (OCT) in conjunction with angiography deliver precise 2D data sets of patient-specific vessel geome-try, which can be used for CFD analysis. Current CFD stud-ies utilize patient-specific geometries, but are lacking well defined physiologic inflow conditions. In this study, we present an inflow mapping method for patient-specific arterial vessels, which is capable of consider-ing the influence of bifurcations located proximal of the OCT-data set. At first, the patient-specific vessel was recon-structed. For this purpose the OCT-based vessel cross sec-tions were arranged along an angiographic based vessel pathway. Secondly, we simulated the flow field in a generic bifurcation model by means of CFD. Thereafter the flow field of a side branch was extracted and transferred (mapped) to the inlet of the patient-specific vessel. To evaluate the influence of the physiological inlet the WSS distribution of the same patient-specific vessel was calculated using an axial-symmetric inflow condition. Analy-sis of the simulation data yielded deviations of the WSS distribution in the proximal vessel segment. A bifurcation, located upstream of the relevant vessel segment strongly affects the flow in the OCT-based vessel reconstruction and has a strong influence on the results of the numerical analy-sis. Therefore, it is important to implement not only the pa-tient-specific geometry, but also an inlet boundary condition adapted to the upstream velocity distribution reflecting the actual proximal flow situation of the vessel.
Quantifying the Influence of Rebuffering Interruptions on the User's Quality of Experience During Mobile Video Watching

Entertainment and multimedia are the key functionalities in emerging mobile markets. The ability to understand and quantify the quality of experience (QoE, i.e., the users' subjective perception of the “overall acceptability of an application or service”), will play a major role in the success of these mobile services. This study explores the thresholds at which the technical quality of a mobile video service becomes unacceptable for users. A subjective experiment drawing on the logging of technical parameters combined with subjective evaluations by a user panel resulted in a model for quantifying the acceptability of video interruptions. The results of this analysis provide insights into the QoE and (un)acceptability regarding video interruptions for different network conditions and video parameters. The conclusions of this paper can be used as a guideline for service design and network dimensioning.
Real-Time Ozone Detection Based on a Microfabricated Quartz Crystal Tuning Fork Sensor

A chemical sensor for ozone based on an array of microfabricated tuning forks is described. The tuning forks are highly sensitive and stable, with low power consumption and cost. The selective detection is based on the specific reaction of the polymer with ozone. With a mass detection limit of ∼2 pg/mm2 and response time of 1 second, the sensor coated with a polymer sensing material can detect ppb-level ozone in air. The sensor is integrated into a miniaturized wearable device containing a detection circuit, filtration, battery and wireless communication chip, which is ideal for personal and microenvironmental chemical exposure monitoring.
Magnetobiosensors based on viral protein p19 for microRNA determination in cancer cells and tissues.

MicroRNAs (miRs) have emerged as important clinical biomarkers with both diagnostic and prognostic value for relevant diseases, such as cancer. MiRs pose unique challenges for detection and are currently detected by northern blotting, real-time PCR, and microarray techniques. These expensive, complicated, and time-consuming techniques are not feasible for on-site miR determination. In this study, amperometric magnetobiosensors involving RNA-binding viral protein p19 as a selective biorecognition element were developed for miR quantification. The p19-based magnetosensors were able to detect 0.4 fmol of a synthetic target and endogenous miR-21 (selected as a model for its role in a wide variety of cancers) in only 2 h in total RNA extracted from cancer cells and human breast-tumor specimens without PCR amplification and sample preprocessing. These results open up formidable perspectives for the diagnosis and prognosis of human cancers and for drug-discovery programs.
Stem cell therapies in preclinical models of stroke associated with aging

Stroke has limited treatment options, demanding a vigorous search for new therapeutic strategies. Initial enthusiasm to stimulate restorative processes in the ischemic brain by means of cell-based therapies has meanwhile converted into a more balanced view recognizing impediments related to unfavorable environments that are in part related to aging processes. Since stroke afflicts mostly the elderly, it is highly desirable and clinically important to test the efficacy of cell therapies in aged brain microenvironments. Although widely believed to be refractory to regeneration, recent studies using both neural precursor cells and bone marrow-derived mesenchymal stem cells for stroke therapy suggest that the aged rat brain is not refractory to cell-based therapy, and that it also supports plasticity and remodeling. Yet, important differences exist in the aged compared with young brain, i.e., the accelerated progression of ischemic injury to brain infarction, the reduced rate of endogenous neurogenesis and the delayed initiation of neurological recovery. Pitfalls in the development of cell-based therapies may also be related to age-associated comorbidities, e.g., diabetes or hyperlipidemia, which may result in maladaptive or compromised brain remodeling, respectively. These age-related aspects should be carefully considered in the clinical translation of restorative therapies.
Erectile dysfunction risk factors for patients entering dialysis programme

The objective of this study was to determine the risk factors of erectile dysfunction (ED) for patients entering the dialysis programme with haemodialysis (HD) or peritoneal dialysis (PD). Participants were adult males with sexual partners. They were given the semi‐quantitative standard International Index of Erectile Function questionnaire. We added the common risk factors in specially designed questions to cover our objectives. The data were analysed using a multivariate regression model. Fifty‐two patients fulfilled the eligibility criteria and completed this questionnaire. Twenty‐five were on HD and 27 on PD. Only 17.3% were potent on entry into the study. Among the rest 71% were classified under severe ED. Sexual desire appeared less affected in comparison to other domains. Although 66.6% expressed their interest in treatment for ED, none of the patients received any. Stepwise selection analysis identified the only significant risk factor to be older age. There was no difference between the two populations of HD and PD. It is concluded that ED is very prevalent in men beginning dialysis; it should be assessed and treatment be offered.
PFO Closure: CLOSURE

The optimal secondary prevention strategy in patients presenting with a cryptogenic stroke or transient ischemic attack (TIA) and a patent foramen ovale (PFO) is uncertain. In the United States, closure of a PFO using a percutaneous transcatheter device is currently considered investigational by the Food and Drug Administration. Nonetheless, many patients in this setting are treated off-label with devices that are approved for the closure of secundum atrial septal defects. There are also no definitive data about the use of medical therapy for secondary stroke prevention in this patient population. We evaluated the potential benefit of device closure of a PFO in this setting in CLOSURE I (evaluation of the STARFlex Septal Closure System in patients with a stroke and/or TIA because of presumed paradoxical embolism through a PFO). 1 CLOSURE I was a prospective, multicenter, randomized, open-label, 2-arm superiority trial. The trial was sponsored by NMT Medical, Inc. The protocol was designed by the Executive Committee in consultation with the Food and Drug Administration, and was approved by the institutional review board at each participating site. Methodological details have been previously published.1,2 ### Study Subjects Subjects were eligible for randomization if they were aged between 18 and 60 years, had had an ischemic stroke or TIA within the previous 6 months, and had evidence of a PFO with right to left shunting documented by a transesophageal echocardiogram. Exclusion criteria included any identified potential source of ischemic stroke or TIA other than the PFO.2 ### Study Procedures Eligible patients were randomly assigned in a 1:1 ratio to either device therapy or medical therapy. Randomization was stratified by study site and by presence or absence of an atrial septal aneurysm. Patients assigned to device therapy underwent percutaneous closure of their PFO with the STARFlex device (NMT Medical, Inc). After the procedure, all patients …
Les environnements : en avoir ou pas ? Formalisation du concept et patterns d'implémentation

Dans le domaine des systemes multi-agents la notion d'environnement est omnipresente, quoique fort mal definie. Nous defendons ici l'idee que la facon dont on modelise l'espace ou les relations entre agents dans un SMA, notamment en simulation, conduit pour leur implementation a la mise en œuvre d'un nombre reduit de solutions efficaces. Cet article a pour objectif de formaliser les fonctions fondamentales de l'environnement et de recenser differentes familles d'implementations possibles, selon les objectifs vises (efficacite d'execution, pertinence de la representation des connaissances, gain memoire.). Cette demarche unificatrice permet d'identifier des patterns d'environnements elementaires : des lors, en lieu et place de l'approche monolithique habituelle de "l'environnement" d'un SMA, nous pronons une decomposition sur la base de ces patterns permettant de combiner plusieurs environnements.