Miracle-dz/UniFAR-FTUs huggingface dataset:
Hazardous cosleeping environments and risk factors amenable to change: case-control study of SIDS in south west England

Objectives To investigate the factors associated with sudden infant death syndrome (SIDS) from birth to age 2 years, whether recent advice has been followed, whether any new risk factors have emerged, and the specific circumstances in which SIDS occurs while cosleeping (infant sharing the same bed or sofa with an adult or child). Design Four year population based case-control study. Parents were interviewed shortly after the death or after the reference sleep (within 24 hours) of the two control groups. Setting South west region of England (population 4.9 million, 184 800 births). Participants 80 SIDS infants and two control groups weighted for age and time of reference sleep: 87 randomly selected controls and 82 controls at high risk of SIDS (young, socially deprived, multiparous mothers who smoked). Results The median age at death (66 days) was more than three weeks less than in a study in the same region a decade earlier. Of the SIDS infants, 54% died while cosleeping compared with 20% among both control groups. Much of this excess may be explained by a significant multivariable interaction between cosleeping and recent parental use of alcohol or drugs (31% v 3% random controls) and the increased proportion of SIDS infants who had coslept on a sofa (17% v 1%). One fifth of SIDS infants used a pillow for the last sleep (21% v 3%) and one quarter were swaddled (24% v 6%). More mothers of SIDS infants than random control infants smoked during pregnancy (60% v 14%), whereas one quarter of the SIDS infants were preterm (26% v 5%) or were in fair or poor health for the last sleep (28% v 6%). All of these differences were significant in the multivariable analysis regardless of which control group was used for comparison. The significance of covering the infant’s head, postnatal exposure to tobacco smoke, dummy use, and sleeping in the side position has diminished although a significant proportion of SIDS infants were still found prone (29% v 10%). Conclusions Many of the SIDS infants had coslept in a hazardous environment. The major influences on risk, regardless of markers for socioeconomic deprivation, are amenable to change and specific advice needs to be given, particularly on use of alcohol or drugs before cosleeping and cosleeping on a sofa.
The surface of Venus

Venus is a planet that is similar to Earth in terms of some important planetary parameters (size, mass, position in the solar system, presence of atmosphere) and different in terms of other, equally important ones (absence of an intrinsic magnetic field, large atmospheric mass, carbon dioxide composition of the atmosphere, lack of water, very high surface pressure and temperature). The surface morphology of Venus is dominated by the signatures of basaltic volcanism and tectonic deformation. Other geological processes such as impact cratering, aeolian activity and gravity-driven down-slope mass movement, although active on the planet, are certainly of subordinate significance. Venusian volcanism resulted in the formation of vast regional plains, occupying most of the planet's surface, and in the building of numerous volcanic edifices. Venusian tectonic deformation was both compressional and extensional. Scales and, periodically, rates of Venusian volcanism and tectonism were comparable to those on Earth. But Venus shows no evidence of the global plate-tectonic style so dominant in the geology of Earth. The morphological record seen in the Magellan radar images of Venus extends back into geological history not earlier than about 0.5–1 billion years. It is represented by a sequence of units from highly tectonized tessera and densely fractured plains, whose compositional nature is unclear, through moderately deformed basaltic lava plains, and then to only locally deformed basaltic plains and edifices. In the beginning of the time period during which this sequence formed, the rates of volcanic and tectonic activity were significantly higher than in the subsequent time extending to the present. This change in volcanic and tectonic activity may correspond to a change in the convection style in the mantle of Venus.
Energy–Delay Optimization of 64-Bit Carry-Lookahead Adders With a 240 ps 90 nm CMOS Design Example

A methodology for energy-delay optimization of digital circuits is presented. This methodology is applied to minimizing the delay of representative carry-lookahead adders under energy constraints. Impact of various design choices, including the carry-lookahead tree structure and logic style, are analyzed in the energy-delay space and verified through optimization. The result of the optimization is demonstrated on a design of the fastest adder found, a 240-ps Ling sparse domino adder in 1 V, 90 nm CMOS. The optimality of the results is assessed against the impact of technology scaling.
Women, Infant and Children (WIC) peer counselor contact with first time breastfeeding mothers.

OBJECTIVE This study was designed to determine whether singleton women who had not previously breastfed and who had a women, infant and children (WIC) peer counselor were more likely to initiate breastfeeding than women not exposed to the WIC peer counselor. DESIGN AND SAMPLE The retrospective cross-sectional study used data from the 2009 Texas Department of State Health Services (DSHS) WIC Infant Feeding Practices Survey (IFPS) administered through 73 local WIC agencies. Of the 5,427 responses to the 2009 Texas DSHS WIC IFP Survey, 56.6% (N = 3,070) were included in this study. MEASURES The Texas DSHS WIC IFPS, a 55-item survey with multiple-choice and two open-ended questions, was used to evaluate breastfeeding beliefs, attitudes, and practices among women receiving WIC services. RESULTS Women who had peer counselor contact during pregnancy, in the hospital, and after delivery were more likely to initiate breastfeeding than women without such contacts, OR = 1.36, 2.06, 1.85, respectively. CONCLUSION Women's decision to initiate breastfeeding is significantly associated with WIC peer counselor contacts. Continued WIC peer counselor program services may increase breastfeeding initiation rates among WIC participants.
Modeling the Circle of Willis Using Electrical Analogy Method under both Normal and Pathological Circumstances

Background and objective: The circle of Willis (COW) supports adequate blood supply to the brain. The cardiovascular system, in the current study, is modeled using an equivalent electronic system focusing on the COW. Methods: In our previous study we used 42 compartments to model whole cardiovascular system. In the current study, nevertheless, we extended our model by using 63 compartments to model whole CS. Each cardiovascular artery is modeled using electrical elements, including resistor, capacitor, and inductor. The MATLAB Simulink software is used to obtain the left and right ventricles pressure as well as pressure distribution at efferent arteries of the circle of Willis. Firstly, the normal operation of the system is shown and then the stenosis of cerebral arteries is induced in the circuit and, consequently, the effects are studied. Results: In the normal condition, the difference between pressure distribution of right and left efferent arteries (left and right ACA–A2, left and right MCA, left and right PCA–P2) is calculated to indicate the effect of anatomical difference between left and right sides of supplying arteries of the COW. In stenosis cases, the effect of internal carotid artery occlusion on efferent arteries pressure is investigated. The modeling results are verified by comparing to the clinical observation reported in the literature. Conclusion: We believe the presented model is a useful tool for representing the normal operation of the cardiovascular system and study of the pathologies.
Performance of a beacon enabled IEEE 802.15.4 cluster with downlink and uplink traffic

The performance of an IEEE 802.15. 4 compliant network operating in the beacon enabled mode with both downlink and uplink traffic is analyzed through discrete time Markov chains and the theory of M/G/1 queues. The model considers acknowledged transmissions and includes the impact of different network and traffic parameters such as the packet arrival rate, packet size, inactive period between the beacons, and the number of stations. We investigate the nonsaturation region and outline the conditions under which the network abruptly goes to saturation. The analysis of stability of the network queues shows that the stability of the downlink queue at the coordinator is the most critical for network operation. Due to the abruptness with which the switch from nonsaturation to saturation occurs, the network operating point has to be carefully chosen according to the volume of downlink traffic. Furthermore, our model shows that certain features prescribed by the standard actually limit the performance of 802.15. 4 networks.
An Exploratory Analysis of Two Iterative Linear Programming—Simulation Approaches for Production Planning

Production planning models that aim at determining optimal release schedules for production facilities face a fundamental circularity. In order to match supply to demand in an optimal manner, they must recognize the cycle time that elapses between material being released into the plant and its emergence as finished product. However, it is well known from queuing models that the mean cycle time increases nonlinearly with resource utilization, which is determined by the release schedule. To address this circularity, a number of authors have suggested algorithms which iterate between a linear programming model that determines releases for a set of flow time estimates, and a simulation model that evaluates the production realized from that release schedule. We present computational experiments examining the behavior of two such algorithms. We find that the convergence behavior of one is significantly more consistent than that of the other, and explore insights that may lead to improved algorithms.
The Devil's in The Details: Placing Decoy Routers in the Internet

Decoy Routing, the use of routers (rather than end hosts) as proxies, is a new direction in anti-censorship research. Decoy Routers (DRs), placed in Autonomous Systems, proxy traffic from users; so the adversary, e.g. a censorious government, attempts to avoid them. It is quite difficult to place DRs so the adversary cannot route around them -- for example, we need the cooperation of 850 ASes to contain China alone [1]. In this paper, we consider a different approach. We begin by noting that DRs need not intercept all the network paths from a country, just those leading to Overt Destinations, i.e. unfiltered websites hosted outside the country (usually popular ones, so that client traffic to the OD does not make the censor suspicious). Our first question is -- How many ASes are required for installing DRs to intercept a large fraction of paths from e.g. China to the top-n websites (as per Alexa)? How does this number grow with n ? To our surprise, the same few (≈ 30) ASes intercept over 90% of paths to the top n sites worldwide, for n = 10, 20.200 and also to other destinations. Investigating further, we find that this result fits perfectly with the hierarchical model of the Internet [2]; our first contribution is to demonstrate with real paths that the number of ASes required for a world-wide DR framework is small (≈ 30). Further, censor nations' attempts to filter traffic along the paths transiting these 30 ASes will not only block their own citizens, but others residing in foreign ASes. Our second contribution in this paper is to consider the details of DR placement: not just in which ASes DRs should be placed to intercept traffic, but exactly where in each AS. We find that even with our small number of ASes, we still need a total of about 11, 700 DRs. We conclude that, even though a DR system involves far fewer ASes than previously thought, it is still a major undertaking. For example, the current routers cost over 10.3 billion USD, so if Decoy Routing at line speed requires all-new hardware, the cost alone would make such a project unfeasible for most actors (but not for major nation states).
A systematic review of the effectiveness of smoking relapse prevention interventions for abstinent smokers.

AIMS To carry out a systematic review of the effectiveness of relapse prevention interventions (RPIs) among abstinent smokers who had completed an initial course of treatment or who had abstained unassisted, pooling only outcome data from similar follow-up time points. METHODS We used the same search strategy as was used in Cochrane reviews of RPIs to identify randomized trials of behavioural and pharmacological studies of smoking RPIs published up to July 2008. Abstinence from smoking was defined as either continuous abstinence or point prevalence abstinence, measured at three follow-up time points: short term (1-3 months post randomization), medium term (6-9 months) and long term (12-18 months). Abstinence among pregnant/postpartum women was also measured at delivery or the last follow-up prior to delivery. Random effect meta-analysis was used to estimate pooled odds ratios (OR) with 95% confidence intervals (CI). RESULTS Thirty-six studies randomizing abstainers were included. Self-help materials appeared to be effective in preventing relapse at long-term follow up in initially unaided quitters (pooled OR 1.52; 95% CI 1.15 to 2.01, I2 = 0%, NNT = 11, 3 studies). Other behavioural interventions for relapse prevention appeared effective in the short term only. There were positive results for the use of pharmacotherapies for relapse prevention. Bupropion was effective at long-term follow-up (pooled OR 1.49; 95% CI 1.10 to 2.01; I2 = 0%; NNT = 11; 4 studies). Nicotine replacement therapy (NRT) was effective at medium-term (pooled OR 1.56; 95% CI 1.16 to 2.11; I2 = 37%; NNT = 14; 4 trials) and long-term follow-ups (pooled OR 1.33; 95% CI 1.08 to 1.63; I2 = 0%; NNT = 20; 4 trials). Single trials of extended treatment of Varenicline and rimonabant were also found to be effective at short-term and medium-term follow-ups. CONCLUSIONS Self-help materials appear to prevent relapse in initially unaided quitters. Use of NRT, bupropion and varenicline appears to be effective in preventing relapse following an initial period of abstinence or an acute treatment episode. There is currently no good evidence that behavioural support prevents relapse after initial unaided abstinence or following an acute treatment period.
Chronic bilateral renal denervation reduces cardiac hypertrophic remodelling but not β‐adrenergic responsiveness in hypertensive type 1 diabetic rats

What is the central question of this study? Can bilateral renal denervation, an effective antihypertensive treatment in clinical and experimental studies, improve cardiac β‐adrenoceptor responsiveness in a diabetic model with underlying hypertension? What is the main finding and its importance? Bilateral renal denervation did not affect β‐adrenergic responsiveness in the diabetic hypertensive rat heart, but denervation reduced the hypertension‐induced concentric hypertrophic remodelling. This suggests that the positive haemodynamic changes induced by renal denervation are most likely to reflect an attenuation of sympathetic effects on the systemic vasculature and/or the renal function rather than direct sympathetic modulation of the heart.
Packing Unequal Circles into a Square Container by Partitioning Narrow Action Spaces and Circle Items

We address the NP-hard problem of finding a non-overlapping dense packing pattern for n Unequal Circle items in a two-dimensional Square Container (PUC-SC) such that the size of the container is minimized. Based on our previous work on an Action Space based Global Optimization (ASGO) that approximates each circle item as a square item to efficiently find the large unoccupied spaces, we propose an optimization algorithm based on the Partitioned Action Space and Partitioned Circle Items (PAS-PCI). The PAS is to partition the narrow action space on the long side to find two equal action spaces to fully utilize the unoccupied spaces. The PCI is to partition the circle items into four groups based on size for the basin hopping strategy. Experiments on two sets of benchmark instances show the effectiveness of the proposed method. In comparison with our previous algorithm ASGO on the 68 tested instances that ASGO published, PAS-PCI not only gains smaller containers in 64 instances and matches the other 4 but also runs faster in most instances. In comparison with the best record of the Packomania website on a total of 98 instances, PAS-PCI finds smaller containers on 82 and matches the other 16. Note that we updated 19 records for (47-48, 51-54, 57, 61-72) that had been kept unchanged since 2013.
Adenosine Deaminase Enhances the Immunogenicity of Human Dendritic Cells from Healthy and HIV-Infected Individuals

ADA is an enzyme implicated in purine metabolism, and is critical to ensure normal immune function. Its congenital deficit leads to severe combined immunodeficiency (SCID). ADA binding to adenosine receptors on dendritic cell surface enables T-cell costimulation through CD26 crosslinking, which enhances T-cell activation and proliferation. Despite a large body of work on the actions of the ecto-enzyme ADA on T-cell activation, questions arise on whether ADA can also modulate dendritic cell maturation. To this end we investigated the effects of ADA on human monocyte derived dendritic cell biology. Our results show that both the enzymatic and non-enzymatic activities of ADA are implicated in the enhancement of CD80, CD83, CD86, CD40 and CCR7 expression on immature dendritic cells from healthy and HIV-infected individuals. These ADA-mediated increases in CD83 and costimulatory molecule expression is concomitant to an enhanced IL-12, IL-6, TNF-α, CXCL8(IL-8), CCL3(MIP1-α), CCL4(MIP-1β) and CCL5(RANTES) cytokine/chemokine secretion both in healthy and HIV-infected individuals and to an altered apoptotic death in cells from HIV-infected individuals. Consistently, ADA-mediated actions on iDCs are able to enhance allogeneic CD4 and CD8-T-cell proliferation, globally yielding increased iDC immunogenicity. Taken together, these findings suggest that ADA would promote enhanced and correctly polarized T-cell responses in strategies targeting asymptomatic HIV-infected individuals.
Causal Effects of Career-Technical Education on Postsecondary Work Outcomes of Individuals with High-Incidence Disabilities

ABSTRACT Using data from the National Longitudinal Transition Study-2, a propensity score analysis revealed significant causal effects for a secondary career and technical education (CTE) concentration on the postsecondary work outcomes of adolescents with high-incidence disabilities. High school students identified as CTE concentrators (three or more high school credits in a single career pathway) were more likely to be employed full-time after high school completion than non-CTE concentrators earning fewer CTE credits. Results support and extend past descriptive and correlational studies by detecting a direct causal link between CTE and postsecondary work outcomes.
Organization of the sea urchin egg endoplasmic reticulum and its reorganization at fertilization

The ER of eggs of the sea urchin Lytechinus pictus was stained by microinjecting a saturated solution of the fluorescent dicarbocyanine DiIC18(3) (DiI) in soybean oil; the dye spread from the oil drop into ER membranes throughout the egg but not into other organelles. Confocal microscopy revealed large cisternae extending throughout the interior of the egg and a tubular membrane network at the cortex. Since diffusion of DiI is confined to continuous bilayers, the spread of the dye supports the concept that the ER is a cell-wide, interconnected compartment. In time lapse observations, the internal cisternae were seen to be in continuous motion, while the cortical ER was stationary. After fertilization, the internal ER appeared to become more finely divided, beginning as a wave apparently coincident with the calcium wave and becoming most marked by 2-3 min. By 5-8 min the ER returned to an organization similar to that of the unfertilized egg. The cortical network also changed at fertilization; it became disrupted and eventually recovered. DiI labeling allowed continuous observations of the ER during pronuclear migration and mitosis. DiI-stained membranes accumulated in the region of the microtubule array surrounding the sperm nucleus and centriole (the sperm aster) as it migrated to the center of the egg; this accumulation persisted near the centrosomes and zygote nucleus throughout pronuclear fusion and the first two mitotic cycles. We have used a new method to observe the spatial and temporal organization of the ER in a living cell, and we have demonstrated a striking reorganization of the ER at fertilization.
Acrosome reaction induced in a limited population of human spermatozoa by progesterone (Ca(2+)-dependent) and ATP (Ca(2+)-independent).

We examined the kinetics of the acrosome reaction induced in human spermatozoa by progesterone (Ca(2+)-dependent) and adenosine 5'-triphosphate (ATP; Ca(2+)-independent). ATP and progesterone did not induce the acrosome reaction unless spermatozoa were incubated in a capacitation medium. ATP exhibited a constant induction of the acrosome reaction regardless of the incubation period, while progesterone began to induce the acrosome reaction after > or = 6 h of incubation. At 24 h of incubation, the percentages of spermatozoa in which the acrosome reaction had been induced by both progesterone and ATP were almost equal. To determine whether a limited population of human spermatozoa was reactive to both progesterone and ATP, we employed an MH61 bead binding method. When the acrosome-reacted spermatozoa were removed with MH61 beads, their percentage in the sperm suspension was decreased to < 3%. At 24 h of incubation, progesterone and ATP induced the acrosome reaction in 12.0 and 10.0% of spermatozoa, respectively. After MH61 bead binding was performed, the remaining spermatozoa did not react to the other activator (progesterone-->ATP, ATP-->progesterone). These findings indicate that only a limited population of human spermatozoa has the potential to undergo the acrosome reaction when stimulated by both progesterone and ATP.