Miracle-dz/UniFAR-FTUs huggingface dataset:
Potential effects of CRM 1 inhibition in mantle cell lymphoma

Mantle cell lymphoma (MCL) is an aggressive histotype of B-cell non-Hodgkin lymphoma. The disease has no known cure, which prompts the urgent need for novel therapeutic agents. Chromosomal region maintenance 1 (CRM1) may play a role in human neoplasia and serve as a novel target of cancer treatment. This study summarizes MCL pathogenesis and determines the involvement of CRM1 in the regulation of several vital signaling pathways contributing to MCL pathogenesis, including the pathways of cell cycle progression, DNA damage response, phosphoinositide kinase-3, nuclear factor-κB activation, and chromosomal stability. A preclinical study is also presented to compare the CRM1 status in MCL cell lines and primary MCL cells with normal B cells, as well as the therapeutic efficiency of CRM1 inhibition in MCL in vitro and in vivo, which make these agents potential targets of novel MCL treatments.
A biomechanical comparison of dominant and non-dominant limbs during a side-step cutting task

Abstract Numerous studies have investigated anterior cruciate ligament (ACL) injury risk by examining gender differences in knee and hip biomechanics during a side-step cutting manoeuvre since it is known that ACL injury often occurs during such a task. Recent investigations have also examined lower extremity (LE) biomechanics during side-step cutting in individuals following ACL reconstruction (ACLR). Common research practice is to compare knee and hip biomechanics of the dominant limb between groups but this can add considerable complexity for clinicians and researchers. At this time, it is not known if there is a difference in LE biomechanics between the dominant and non-dominant limb during side-step cutting. Three-dimensional kinematics and kinetics were collected while 31 healthy participants performed five, side-step cutting manoeuvres with the dominant and non-dominant limbs. Knee and hip variables examined are those commonly investigated in ACL injury literature. There were no differences between limbs in all but one variable (knee internal rotation). These results demonstrate that healthy individuals exhibit little side-to-side differences in certain LE biomechanics when performing a side-step cutting manoeuvre. These findings can be utilised by clinicians when conducting dynamic evaluations of their ACLR patients and when developing injury prevention and rehabilitation programmes.
Real-Time Visual Odometry Based on Optical Flow and Depth Learning

Visual odometer is an algorithm that determines the displacement and rotation angle of a photographing device by analyzing the associated image sequence. We propose a method in which a convolutional neural network is used for both input image data processing and autonomous motion estimation. The first network learns the optical flow by using the convolutional neural networks (CNNs) end-to-end method, and acts as input to the next network. The second network also uses CNNs to study visual features to complete visual motion estimation. Our system uses the KITTI Visual odometry Dataset to train and test, and the system accuracy is calculated by comparing the difference between estimated and actual values. Compared to the traditional optical flow calculation and by using geometric method for ego-motion estimation, our method uses GPU acceleration to achieve 28fps speed, in line with real-time video processing requirements.
Uptake of salmon-derived nitrogen by mosses and liverworts in coastal British Columbia

Throughout forested watersheds bordering the North Pacific, anadromous salmon (Oncorhynchus spp.) are transferred into coastal forests by numerous predators and scavengers with remnants providing an important nutrient subsidy to riparian zones. The contribution of these nutrients to mosses and liverworts, which are the dominant ground cover of coastal forests, has not been investigated. We examine here δ 15 N isotope signatures and foliar percent N of eight moss and liverwort species, as well as moss and liverwort community structure, in multiple habitat blocks that vary in access to salmon nutrients from two watersheds on the central coast of British Columbia. For the most common moss Rhytidiadelphus loreus, we also examine δ 15 N values and foliar percent N among salmon carcass micro-sites and along wildlife trails. Overall, δ 15 N signatures ranged from 2‰ to 7‰ higher below the falls near the salmon stream than above the small falls that are impassable to salmon, or at the adjacent control watershed that had no salmon. Among micro-sites, δ 15 N and %N values were highest near bony carcass remnants from transfer during previous years and high adjacent to wildlife trails indicating spatial heterogeneity in the salmon nutrient pools of these forests. Species richness and prevalence of nitrogen-rich soil indicators were also highest in forests adjacent to the salmon stream. These data suggest an important contribution of salmon-derived nutrients to the non-vascular plants of the riparian zone of old-growth forests throughout the Pacific Rim.
A randomized trial comparing 5-mg and 10-mg warfarin loading doses.

BACKGROUND Warfarin sodium therapy is usually initiated with a loading dose to reduce the time required to elevate the international normalized ratio (INR). Warfarin loading doses are associated with early overanticoagulation and the development of a potential hypercoagulable state; they also may not hasten achieving an INR value between 2.0 and 3.0. This study was designed to prospectively confirm our observation that a 5-mg warfarin sodium loading dose is as effective as a 10-mg loading dose in achieving a therapeutic INR for 2 consecutive days on days 3 and 4 or 4 and 5 of therapy. METHODS Fifty-three patients initiating warfarin therapy with a target INR of 2.0 to 3.0 were randomly allocated to receive an initial dose of 5 or 10 mg of warfarin. Subsequent doses were based on dosing algorithms. The INR was measured daily for 5 days. The primary end point of the study was the proportion of patients whose INR values were between 2.0 and 3.0 on 2 consecutive daily determinations on days 3, 4, or 5 of the study and whose INR did not exceed 3.0 at any point during the study. RESULTS Five (24%) of 21 patients in the 10-mg group and 21 (66%) of 32 patients in the 5-mg group achieved the primary end point (relative risk 2.22, 95% confidence interval 1.30-3.70 [P < .003]). A trend toward less overanticoagulation was seen in the 5-mg warfarin group. CONCLUSION A 10-mg loading dose of warfarin is unlikely to be more effective than a 5-mg loading dose in achieving an INR of 2.0 to 3.0 by day 4 or 5 of therapy.
The Effects of Practice and Coaching on the Air Traffic Selection and Training Test Battery

Abstract : The Air Traffic Selection and Training (AT-SAT) test battery is the Federal Aviation Administration's (FAA's) recently developed computerized selection test for Air Traffic Control Specialists (ATCSs). Only one form of the AT-SAT battery was developed as part of the initial development and validation effort, meaning that all people who take the test receive the exact same items. The goals of the current study were to: 1) determine if repeated test taking improves performance; 2) determine if coaching improves performance; 3) identify specific tests within the AT-SAT battery that are most susceptible to practice and coaching effects; and, 4) determine the extent to which practice and coaching effects potentially impact hiring decisions. Study participants were not ATCSs; however, they had to meet basic requirements for the ATC occupation to be eligible for participation. They were recruited through a contractor and randomly assigned to one of three experimental groups. Group 1 received a one-day coaching intervention before taking the first administration of AT-SAT. Group 2 took the first administration of AT-SAT, and then received the coaching intervention before the second administration. Group 3, the control group, took AT-SAT three times without coaching. Test scores were compared both between and within each group using ANOVA with repeated measures. The results suggest that performance on the AT-SAT battery may indeed be influenced by both practice and coaching effects. More specifically, the results demonstrate that the composite AT-SAT score that is used for hiring decisions increases with repeated administrations, although the greatest increase occurs following coaching. In terms of selection decisions, it is conceivable that coaching could move an individual from a failing status into a passing status and even from the qualified category into the well-qualified category, without improving their ability to perform on the job.
Simulations of gasotransmitter permeation through lipid bilayers

The permeation of gasotransmitter molecules, NO, CO and H₂S, through phospholipid bilayers were studied using molecular dynamics simulations in order to gain insight into the process by which these solutes cross biological membranes. These simulations require accurate representations of both lipids and water components of the simulation. The CHARMM36 lipid model is generally effective at predicting the properties of lipid bilayers, but this model was developed for use with CHARMM TIP3P water model. This water model overestimates the dielectric constant and diffusion coefficient of water, which introduces error into the permeability calculations. The TIP3P-FB and TIP4P-FB water models are more accurate in predicting the dielectric constant and transport properties of water, which could allow for more realistic simulations of membrane permeation. To validate whether these water models are compatible with the CHARMM36 lipid model, the lipid headgroup area, compressibility, order parameters, and scattering form factors were calculated using these models and were generally found to be in good agreement with the experimental values. This indicates that the CHARMM36 model can be used with either of these water models without modification. Using the TIP4P-FB water model and the CHARMM36 lipid force field, the permeation of NO, CO, and H₂S through a POPC lipid bilayer was simulated. These simulations show that the Gibbs energy barriers to permeation are modest for all three gasotransmitters, allowing them to permeate membranes readily. High rates of permeation for NO and H₂S were calculated using the inhomogeneous solubility-diffusion model, in good agreement with experiments. Although no experimental value has been reported, the rate of CO permeation was found to be similar to that of NO. The effect of cholesterol content in the bilayer was also investigated and was found to lower the rates of permeation modestly.
Strong Homotypic Continuity in Common Psychopathology-, Internalizing-, and Externalizing-Specific Factors Over Time in Adolescents

Dimensional models of psychopathology that posit a general psychopathology factor (i.e., p factor), in addition to specific internalizing and externalizing factors, have recently gained prominence. However, the stability of these factors and the specificity with which they are related to one another over time (e.g., homotypic or heterotypic continuity) have not been investigated. The current study addressed these questions. We estimated bifactor models, with p, internalizing-specific, and externalizing-specific factors, with youth and caretaker reports of symptoms at two time points (18 months apart), in a large community sample of adolescents. Results showed strong stability over time with highly specific links (i.e., p factor at Time 1 to Time 2; internalizing-specific at Time 1 to Time 2 and externalizing-specific at Time 1 to Time 2), suggesting strong homotypic continuity between higher order latent psychopathology factors.
Sulfurisphaera javensis sp. nov., a hyperthermophilic and acidophilic archaeon isolated from Indonesian hot spring, and reclassification of Sulfolobus tokodaii Suzuki et al. 2002 as Sulfurisphaera tokodaii comb. nov.

A novel hyperthermophilic, acidophilic and facultatively anaerobic archaeon, strain KD-1T, was isolated from an acidic hot spring in Indonesia and characterized with the phylogenetically related species Sulfurisphaera ohwakuensis Kurosawa et al. 1998, Sulfolobus tokodaii Suzuki et al., 2002 and Sulfolobus yangmingensis Jan et al. 1999. Cells of KD-1T were irregular cocci with diameters of 0.9-1.3 µm. The strain grew at 60-90 °C (optimum 80-85 °C), pH 2.5-6.0 (optimum pH 3.5-4.0) and 0-1.0 % (w/v) NaCl concentration. KD-1T grew anaerobically in the presence of S0 (headspace: H2/CO2) and FeCl3 (headspace: N2). Under aerobic conditions, chemolithoautotrophic growth occurred on S0, pyrite, K2S4O6, Na2S2O3 and H2. This strain utilized various complex substrates, such as yeast extract, but did not grow on sugars and amino acids as the sole carbon source. The main core lipids were calditoglycerocaldarchaeol and caldarchaeol. The DNA G+C content was 30.6 mol%. Analyses of phylogenetic trees based on 16S rRNA and 23S rRNA genes indicated that KD-1T formed an independent lineage near Sulfurisphaera ohwakuensis TA-1T, Sulfolobus tokodaii 7T and Sulfolobus yangmingensis YM1T. On the basis of the results of morphological, physiological, chemotaxonomic and phylogenetic analyses, KD-1T represents a novel species of the genus Sulfurisphaera Kurosawa et al. 1998, for which the name Sulfurisphaera javensis sp. nov. is proposed. The type strain is KD-1T (=JCM 32117T=InaCC Ar81T). Based on the data, we also propose the reclassification of Sulfolobus tokodaii Suzuki et al., 2002 as Sulfurisphaera tokodaii comb. nov. (type strain 7T=JCM 10545T=DSM 16993T).
Green infrastructure and its catchment-scale effects: an emerging science

Urbanizing environments alter the hydrological cycle by redirecting stream networks for stormwater and wastewater transmission and increasing impermeable surfaces. These changes thereby accelerate the runoff of water and its constituents following precipitation events, alter evapotranspiration processes, and indirectly modify surface precipitation patterns. Green infrastructure, or low‐impact development (LID), can be used as a standalone practice or in concert with gray infrastructure (traditional stormwater management approaches) for cost‐efficient, decentralized stormwater management. The growth in LID over the past several decades has resulted in a concomitant increase in research evaluating LID efficiency and effectiveness, but mostly at localized scales. There is a clear research need to quantify how LID practices affect water quantity (i.e., runoff and discharge) and quality at the scale of catchments. In this overview, we present the state of the science of LID research at the local scale, considerations for scaling this research to catchments, recent advances and findings in scaling the effects of LID practices on water quality and quantity at catchment scales, and the use of models as novel tools for these scaling efforts. WIREs Water 2018, 5:e1254. doi: 10.1002/wat2.1254
ASAPP: Alinhamento Semântico Automático de Palavras aplicado ao Português

We present two distinct approaches to the ASSIN shared evaluation task where, given a collection with pairs of sentences, in Portuguese, poses the following challenges: (a)~computing the semantic similarity between the sentences of each pair; and (b)~testing whether one sentence paraphrases or entails the other. The first approach, dubbed Reciclagem, is exclusively based on heuristics computed on Portuguese semantic networks. The second, dubbed ASAPP, is based on supervised machine learning. The results of Reciclagem enable an indirect comparison of Portuguese semantic networks. They were then used as features of the ASAPP approach, together with lexical and syntactic features. After comparing our results with those in the gold collection, it is clear that ASAPP consistently outperforms Reciclagem. This happens both for European Portuguese and Brazilian Portuguese, where the entailment performance reaches an accuracy of 80.28% +- 0.019, and the semantic similarity scores are 66.5% +- 0.021 correlated with those given by humans.
Brain-controlled telepresence robot by motor-disabled people

In this paper we present the first results of users with disabilities in mentally controlling a telepresence robot, a rather complex task as the robot is continuously moving and the user must control it for a long period of time (over 6 minutes) to go along the whole path. These two users drove the telepresence robot from their clinic more than 100 km away. Remarkably, although the patients had never visited the location where the telepresence robot was operating, they achieve similar performances to a group of four healthy users who were familiar with the environment. In particular, the experimental results reported in this paper demonstrate the benefits of shared control for brain-controlled telepresence robots. It allows all subjects (including novel BMI subjects as our users with disabilities) to complete a complex task in similar time and with similar number of commands to those required by manual control.
Targeted Exercises in Phenytoin Toxicity Induced Cerebellar Motor Dysfunction: A Case Report

Purpose: To evaluate the effect of targeted exercises in phenytoin toxicity induced cereballar motor dysfunction. Method: A 45 years old female with simple partial epilepsy under medication phenytoin sodium 200mg/day since seven years. Subject presented with the increased serum phenytoin level around 40.00 more than the normal range 10.00-20.00 all cerebellar test were positive including balance and coordination test. Four weeks physiotherapy management was conducted using coordination exercises, PNF and balance exercises. Result: Four weeks of physiotherapy management along with medical management patients improved balance, coordination and ADL function. Conclusion: Acute reversible Phenytoin toxicity induced cerebellar dysfunction can be managed by providing specific balance, coordination and PNF for upper limb and lower limb.
Triple wavelength fiber laser employing SOA incorporated with a tapered fiber

This paper presents an experimental investigation of a triple lasing wavelength of fiber laser employing bidirectional SOA incorporated with a tapered fiber which operates in the L-band region. This ring configuration comprises of a bidirectional semiconductor optical amplifier and a tapered fiber. Based on the results, a single mode tapered fiber in the configuration has the ability to enhance the wavelength performance in terms of the optical signal to noise ratio and its stability. This tapered optical fiber has a diameter waist of 12 μm, length waist of 10 mm and 5 mm for its uptaper length and downtaper length. Semiconductor optical amplifier injected current varies for 130 mA, 210 mA, and 300 mA to observe fiber laser performance in term of average output power and optical signal to noise ratio. This fiber laser can lase three wavelengths at 1576 nm, 1586 nm and 1596 nm. These triple wavelengths output exhibits an excellent performance by having the average optical signal to noise ratio of 44 dB, and average peak power is -13 dbm. Furthermore, fiber laser employing bidirectional SOA incorporated with a tapered fiber has efficient performance lasing wavelength stability over 60 minutes.
Modeling space-time correlations of velocity fluctuations in wind farms

An analytical model for the streamwise velocity space-time correlations in turbulent flows is derived and applied to the special case of velocity fluctuations in large wind farms. The model is based on the Kraichnan-Tennekes random sweeping hypothesis, capturing the decorrelation in time while including a mean wind velocity in the streamwise direction. In the resulting model, the streamwise velocity space-time correlation is expressed as a convolution of the pure space correlation with an analytical temporal decorrelation kernel. Hence, the spatiotemporal structure of velocity fluctuations in wind farms can be derived from the spatial correlations only. We then explore the applicability of the model to predict spatiotemporal correlations in turbulent flows in wind farms. Comparisons of the model with data from a large eddy simulation of flow in a large, spatially periodic wind farm are performed, where needed model parameters such as spatial and temporal integral scales and spatial correlations are determined from the large eddy simulation. Good agreement is obtained between the model and large eddy simulation data showing that spatial data may be used to model the full spatiotemporal structure of fluctuations in wind farms.
Grammatical Role Embeddings for Enhancements of Relation Density in the Princeton WordNet

In this paper we present an approach for training verb subatom embeddings. For each verb we learn several embeddings rather than only one. These embeddings include the verb itself as well as embeddings for each grammatical role of this verb. To give an example, for the verb ‘to give’ we learn four embeddings: one for the lemma ‘give’, one for the subject, one for the direct object and one for the indirect object. We have exploited these grammatical role embeddings in order to add new syntagmatic relations to WordNet. The evaluation of the new relations quality has been done extrinsically through the Knowledge-based Word Sense Disambiguation task.
Resource allocation optimisation for delay-sensitive traffic in energy harvesting cloud radio access network

In this study, the authors study a sustainable resource allocation scheme for delay-sensitive applications in an energy harvesting (EH)-cloud radio access network (CRAN). The authors formulate an optimisation problem to maximise the user equipment (UE) utility and provide them with strong delay-guarantee by jointly considering the stochastic EH process, dynamic wireless channel state. By using the Lyapunov stochastic network optimisation technique combined with virtual queues, the authors decompose the formulated problem into four sub-problems, including channel allocation, data dropping, UE request scheduling and energy management. Based on the solutions of these sub-problems, a UE optimal resource allocation algorithm is proposed to maximise UE utility while guaranteeing the delay bound and the sustainability of remote radio heads. Furthermore, this algorithm does not require any prior statistical information of the system, e.g. EH process and channel state. Both theoretical analyses and simulation results demonstrate that the proposed algorithm can achieve close-to-optimal UE utility, bounded data buffer, delay-guarantee, and required battery capacity for the operation of the CRAN.
Studies of adults can inform accounts of theory of mind development.

There is strong evidence that developments in children's theory of mind (ToM) at 3? 4 years are related to developments in language and executive function. However, these relationships might exist for 2 reasons. First, language and executive function might be necessary for the mature ToM abilities that children are in the process of developing. Second, language and executive function may be necessary for developing ToM but have no necessary role in mature ToM. It is difficult to distinguish between these possibilities if researchers only study young children. Studies of adults can provide direct evidence about the role of language and executive function in mature ToM. Recent work suggests that impaired executive function has multiple roles in adult ToM but that severely impaired grammar can leave ToM structurally intact. While studies of children report that ToM correlates with both language and executive function, findings from adults suggest that these relationships should be interpreted in importantly different ways.