Miracle-dz/UniFAR-FTUs huggingface dataset:
Robotic‐assisted single‐incision laparoscopic partial cecectomy

Single‐incision laparoscopic surgery is an emerging approach in the field of minimally invasive colon and rectal surgery. This modality utilizes a ‘scarless’ incision concealed within the umbilicus, and results in improved cosmesis with the potential for reduced trauma, pain and length of hospital stay. However, unique technical challenges have curbed its adaptation. Robotic‐assisted technique may help overcome these limitations when applied to the single‐incision approach.
A Cross-Layer Optimization Approach for Energy Efficient Wireless Sensor Networks: Coalition-Aided Data Aggregation, Cooperative Communication, and Energy Balancing

We take a cross-layer optimization approach to study energy efficient data transport in coalition-based wireless sensor networks, where neighboring nodes are organized into groups to form coalitions and sensor nodes within one coalition carry out cooperative communications. In particular, we investigate two network models: (1) many-to-one sensor networks where data from one coalition are transmitted to the sink directly, and (2) multihop sensor networks where data are transported by intermediate nodes to reach the sink. For the many-to-one network model, we propose three schemes for data transmission from a coalition to the sink. In scheme 1, one node in the coalition is selected randomly to transmit the data; in scheme 2, the node with the best channel condition in the coalition transmits the data; and in scheme 3, all the nodes in the coalition transmit in a cooperative manner. Next, we investigate energy balancing with cooperative data transport in multihop sensor networks. Built on the above coalition-aided data transmission schemes, the optimal coalition planning is then carried out in multihop networks, in the sense that unequal coalition sizes are applied to minimize the difference of energy consumption among sensor nodes. Numerical analysis reveals that energy efficiency can be improved significantly by the coalition-aided transmission schemes, and that energy balancing across the sensor nodes can be achieved with the proposed coalition structures.
Information conversion, effective samples, and parameter size

Consider the relative entropy between a posterior density for a parameter given a sample and a second posterior density for the same parameter, based on a different model and a different data set. Then the relative entropy can be minimized over the second sample to get a virtual sample that would make the second posterior as close as possible to the first in an informational sense. If the first posterior is based on a dependent dataset and the second posterior uses an independence model, the effective inferential power of the dependent sample is transferred into the independent sample by the optimization. Examples of this optimization are presented for models with nuisance parameters, finite mixture models, and models for correlated data. Our approach is also used to choose the effective parameter size in a Bayesian hierarchical model.
Recognition of real time voiced direction commands

In this paper, five different voiced direction command recognition is realized in real-time. Speech detection step is performed on voice recordings that includes five different direction commands. Mel frequency cepstrum coefficients (MFCC) and Linear Predictive Coding (LPC) coefficients are utilized to extract feature vectors and training data set. k-nearest neighbor classification algorithm is used at the testing stage. The testing stage is realized with recordings from voices that included in the training data set and also with the voices that is not included in the training data set in real time. In the discussion, the results of the offline and online test are compared. All the studies are performed in the MATLAB environment.
IL-1β Impairs Insulin-Like Growth Factor I-Induced Differentiation and Downstream Activation Signals of the Insulin-Like Growth Factor I Receptor in Myoblasts1

Proinflammatory cytokines are elevated in disorders characterized by muscle wasting and weakness, such as inflammatory myopathies and AIDS wasting. We recently demonstrated that TNF-α impairs the ability of insulin-like growth factor (IGF)-I to promote protein synthesis in muscle precursor cells. In this study we extend these findings by showing that low concentrations of IL-1β impair IGF-I-dependent differentiation of myoblasts, as assessed by expression of the muscle specific protein, myosin heavy chain. In the absence of exogenous IGF-I, IL-1β (1 ng/ml) did not impair muscle cell development. However, in the presence of IGF-I, 100-fold lower concentrations of IL-1β (0.01 ng/ml) significantly suppressed myoblast differentiation, protein synthesis, and myogenin expression. Increasing IL-1β to 1 ng/ml completely blocked the anabolic actions of IGF-I in murine C2C12 myoblasts. Similarly, IL-1β inhibited IGF-I-stimulated protein synthesis in primary porcine myoblasts. IL-1β impaired the actions of IGF-I at a point distal to the IGF receptor, and this was not due to IL-1β-induced cell death. Instead, IL-1β inhibited the ability of IGF-I to phosphorylate tyrosine residues on both of its downstream docking proteins, insulin receptor substrate 1 and insulin receptor substrate 2. These data establish that physiological concentrations of IL-1β block the ability of IGF-I to promote protein synthesis, leading to reduced expression of the myogenic transcription factor, myogenin, and the subsequent development of more mature differentiated cells that express myosin heavy chain. Collectively, the results are consistent with the notion that very low concentrations of IL-1β significantly impair myogenesis, but they are unable to do so in the absence of the growth factor IGF-I.
Effect of a High Salt Diet on Microvascular Antioxidant Enzymes

High dietary salt intake decreases the endothelium-dependent dilation of skeletal muscle arterioles by inhibiting local nitric oxide (NO) activity without changing vascular smooth muscle responsiveness to NO. Under these conditions, microvascular walls show evidence of oxidative stress, and scavengers of reactive oxygen species (ROS) abolish this oxidative stress and restore normal arteriolar responses to acetylcholine (ACh). We tested the hypothesis that the salt-dependent appearance of microvascular ROS, and accompanying reduction in endothelium-dependent dilation, is due to a decrease in antioxidant enzyme expression or activity. We studied spinotrapezius muscle microvessels in rats fed normal (NS) (0.45%) or high (HS) (7%) salt diets for 4–5 weeks. Western analysis of arteriolar and venular protein showed no difference between groups in the content of superoxide dismutase (Cu/Zn SOD), catalase, or glutathione peroxidase. The catalase inhibitor 3-amino-1,2,4-triazole (3AT) increased arteriolar and venular oxidant activity (assessed by tetranitroblue tetrazolium reduction) by the same amount in both groups, suggesting similar levels of catalase activity. 3AT did not affect arteriolar responses to ACh in either group. The Cu/Zn SOD inhibitor diethyldithiocarbamate increased arteriolar and venular oxidant activity to a lesser extent in HS rats, suggesting reduced Cu/Zn SOD activity in this group. Cu/Zn SOD inhibition decreased arteriolar responses to ACh only in NS rats. These findings suggest that endogenous Cu/Zn SOD preserves the endothelium-dependent control of arteriolar tone in NS rats, and that a reduction in Cu/Zn SOD activity contributes to the loss of arteriolar NO activity in HS rats.
Age-related differences in the respiratory microbiota of chickens

In this era of next generation sequencing technologies it is now possible to characterise the chicken respiratory microbiota without the biases inherent to traditional culturing techniques. However, little research has been performed in this area. In this study we characterise and compare buccal, nasal and lung microbiota samples from chickens in three different age groups using 16S rRNA gene analysis. Buccal and nasal swabs were taken from birds aged 2 days (n = 5), 3 weeks (n = 5) and 30 months (n = 6). Bronchoalveolar lavage (BAL) samples were also collected alongside reagent only controls. DNA was extracted from these samples and the V2-V3 region of the 16S rRNA gene was amplified and sequenced. Quality control and OTU clustering were performed in mothur. Bacterial DNA was quantified using qPCR, amplifying the V3 region of the 16S rRNA gene. We found significant differences between the quantity and types of bacteria sampled at the three different respiratory sites. We also found significant differences in the composition, richness and diversity of the bacterial communities in buccal, nasal and BAL fluid samples between age groups. We identified several bacteria which had previously been isolated from the chicken respiratory tract in culture based studies, including lactobacilli and staphylococci. However, we also identified bacteria which have not previously been cultured from the respiratory tract of the healthy chicken. We conclude that our study can be used as a baseline that future chicken respiratory microbiota studies can build upon.
Analysis and characterisation of botnet scan traffic

Botnets compose a major source of malicious activity over a network and their early identification and detection is considered as a top priority by security experts. The majority of botmasters rely heavily on a scan procedure in order to detect vulnerable hosts and establish their botnets via a command and control (C&C) server. In this paper we examine the statistical characteristics of the scan process invoked by the Mariposa and Zeus botnets and demonstrate the applicability of conditional entropy as a robust metric for profiling it using real pre-captured operational data. Our analysis conducted on real datasets demonstrates that the distributional behaviour of conditional entropy for Mariposa and Zeus-related scan flows differs significantly from flows manifested by the commonly used NMAP scans. In contrast with the typically used by attackers Stealth and Connect NMAP scans, we show that consecutive scanning flows initiated by the C&C servers of the examined botnets exhibit a high dependency between themselves in regards of their conditional entropy. Thus, we argue that the observation of such scan flows under our proposed scheme can sufficiently aid network security experts towards the adequate profiling and early identification of botnet activity.
Assembling the glycopeptide antibiotic scaffold: The biosynthesis of from Streptomyces toyocaensis NRRL15009

The glycopeptide antibiotics vancomycin and teicoplanin are vital components of modern anti-infective chemotherapy exhibiting outstanding activity against Gram-positive pathogens including members of the genera Streptococcus, Staphylococcus, and Enterococcus. These antibiotics also provide fascinating examples of the chemical and associated biosynthetic complexity exploitable in the synthesis of natural products by actinomycetes group of bacteria. We report the sequencing and annotation of the biosynthetic gene cluster for the glycopeptide antibiotic A47934 from Streptomyces toyocaensis NRRL15009, the first complete sequence for a teicoplanin class glycopeptide. The cluster includes 34 ORFs encompassing 68 kb and includes all of the genes predicted to be required to synthesize A47934 and regulate its biosynthesis. The gene cluster also contains ORFs encoding enzymes responsible for glycopeptide resistance. This role was confirmed by insertional inactivation of the d-Ala-d-lactate ligase, vanAst, which resulted in the predicted A47934-sensitive phenotype and impaired antibiotic biosynthesis. These results provide increased understanding of the biosynthesis of these complex natural products.
Transporter-mediated permeation of drugs across the blood-brain barrier.

Drug distribution into the brain is strictly regulated by the presence of the blood-brain barrier (BBB) that is formed by brain capillary endothelial cells. Since the endothelial cells are connected to each other by tight junctions and lack pores and/or fenestrations, compounds must cross the membranes of the cells to enter the brain from the bloodstream. Therefore, hydrophilic compounds cannot cross the barrier in the absence of specific mechanisms such as membrane transporters or endocytosis. So, for efficient supply of hydrophilic nutrients, the BBB is equipped with membrane transport systems and some of those transporter proteins have been shown to accept drug molecules and transport them into brain. In the present review, we describe mainly the transporters that are involved in drug transfer across the BBB and have been molecularly identified. The transport systems described include transporters for amino acids, monocarboxylic acids, organic cations, hexoses, nucleosides, and peptides. Most of these transporters function in the direction of influx from blood to brain; the presence of efflux transporters from brain to blood has also been demonstrated, including P-glycoprotein, MRPs, and other unknown transporters. These efflux transporters seem to be functional for detoxication and/or prevention of nonessential compounds from entering the brain. Various drugs are transported out of the brain via such efflux transporters, resulting in the decrease of CNS side effects for drugs that have pharmacological targets in peripheral tissues or in the reduction of efficacy in CNS because of the lower delivery by efflux transport. To identify the transporters functional at the BBB and to examine the possible involvement of them in drug transports by molecular and physiological approaches will provide a rational basis for controlling drug distribution to the brain.
The Effectiveness of Group Triple P and the Impact of the Four Telephone Contacts

Abstract The aim of this study was to determine the efficacy of the four telephone contact sessions that are prescribed as an integral component of the Group Triple P parenting program, and to compare the efficacy of Group Triple P to a waitlist control group. Parents of children aged 2 to 8 years were randomly assigned to one of three conditions: the usual Group Triple P program, consisting of four group sessions and four telephone calls (n = 16); a modified Group Triple P condition, consisting of just the four group sessions (n = 17); or a waitlist control condition (n = 16). Pre- and post-intervention assessments were conducted using the Eyberg Child Behavior Inventory (ECBI), the Depression Anxiety Stress Scales (DASS) and the Parenting Scale (PS). Statistically and clinically significant main effects were found for attending either the full Triple P or the modified Triple P program on both the DASS and the ECBI, but not on the participant's perception of their parenting style (PS). We conclude that (a) the four telephone sessions are not an essential component for the initial effectiveness of the Group Triple P program (though further research needs to explore whether they impact on maintenance of gains), and (b) that Group Triple P is effective in bringing about change, as measured using these self-report instruments.
International Examples of Large-Scale Systems - Theory and Practice II: A Case Study of Managing IT Outsourcing Partnerships in Asia

This case study describes an Asian Information Technology (IT) outsourcing partnership in the discrete manufacturing industry. Interviews with business and IT executives of both the Outsourcing Company and the IT Services Supplier provided the necessary insights. Nowadays many organizations in discrete manufacturing move their plants to Asian countries or other lower wages countries. Most IT services suppliers in Asia are relatively inexperienced with the management of IT outsourcing relationships. However, not only are the IT services suppliers inexperienced, the outsourcing companies do not have a track record in managing IT outsourcing relationships. Cultural issues also play an important role, especially power distance and collectivism. Contrary to the level of experience, cultural factor do not change over a few years. This article aims to provide a better understanding of managing IT outsourcing partnerships in developing Asian countries on the basis of an IT outsourcing partnership model.
Clozapine Associated Neutropenia and Cytomegalovirus Colitis

Both diarrhea and colitis associated with clozapine have been reported. We present a case of clozapine-associated neutropenia complicated by cytomegalovirus colitis. The definitive diagnosis was suggested on biopsy which showed eosinophilic intranuclear inclusions suggestive of cytomegalovirus infection, and confirmed on immunohistochemistry. Neutropenia or agranulocytosis in association with clozapine treatment may be complicated by colitis. In such cases, investigations for cytomegalovirus may be indicated.
Fusion of Heterogeneous Speaker Recognition Systems in the STBU Submission for the NIST Speaker Recognition Evaluation 2006

This paper describes and discusses the "STBU" speaker recognition system, which performed well in the NIST Speaker Recognition Evaluation 2006 (SRE). STBU is a consortium of four partners: Spescom DataVoice (Stellenbosch, South Africa), TNO (Soesterberg, The Netherlands), BUT (Brno, Czech Republic), and the University of Stellenbosch (Stellenbosch, South Africa). The STBU system was a combination of three main kinds of subsystems: 1) GMM, with short-time Mel frequency cepstral coefficient (MFCC) or perceptual linear prediction (PLP) features, 2) Gaussian mixture model-support vector machine (GMM-SVM), using GMM mean supervectors as input to an SVM, and 3) maximum-likelihood linear regression-support vector machine (MLLR-SVM), using MLLR speaker adaptation coefficients derived from an English large vocabulary continuous speech recognition (LVCSR) system. All subsystems made use of supervector subspace channel compensation methods-either eigenchannel adaptation or nuisance attribute projection. We document the design and performance of all subsystems, as well as their fusion and calibration via logistic regression. Finally, we also present a cross-site fusion that was done with several additional systems from other NIST SRE-2006 participants.
A unified nomenclature system for the insect olfactory coreceptor.

We propose a revised nomenclature for the insect olfactory coreceptor variously named ‘‘Or83b,’’ ‘‘Or1,’’ ‘‘Or2,’’ and ‘‘Or7. ’’ This gene appears to be functionally orthologous across all insects and serves as a chaperoning coreceptor for the odor- and pheromone-specific subunits of the insect
Psychological conceptions of randomness

This article presents a critique of the concept of randomness as it occurs in the psychological literature. The first section of our article outlines the significance of a concept of randomness to the process of induction; we need to distinguish random and non-random events in order to perceive lawful regularities and formulate theories concerning events in the world. Next we evaluate the psychological research that has suggested that human concepts of randomness are not normative. We argue that, because the tasks set to experimental subjects are logically problematic, observed biases may be an artifact of the experimental situation and that even if such biases do generalise they may not have pejorative implications for induction in the real world. Thirdly we investigate the statistical methodology utilised in tests for randomness and find it riddled with paradox. In a fourth section we find various branches of scientific endeavour that are stymied by the problems posed by randomness. Finally we briefly mention the social significance of randomness and conclude by arguing that such a fundamental concept merits and requires more serious considerations.
Arginine residues at internal positions in a protein are always charged

Many functionally essential ionizable groups are buried in the hydrophobic interior of proteins. A systematic study of Lys, Asp, and Glu residues at 25 internal positions in staphylococcal nuclease showed that their pKa values can be highly anomalous, some shifted by as many as 5.7 pH units relative to normal pKa values in water. Here we show that, in contrast, Arg residues at the same internal positions exhibit no detectable shifts in pKa; they are all charged at pH ≤ 10. Twenty-three of these 25 variants with Arg are folded at both pH 7 and 10. The mean decrease in thermodynamic stability from substitution with Arg was 6.2 kcal/mol at this pH, comparable to that for substitution with Lys, Asp, or Glu at pH 7. The physical basis behind the remarkable ability of Arg residues to remain protonated in environments otherwise incompatible with charges is suggested by crystal structures of three variants showing how the guanidinium moiety of the Arg side chain is effectively neutralized through multiple hydrogen bonds to protein polar atoms and to site-bound water molecules. The length of the Arg side chain, and slight deformations of the protein, facilitate placement of the guanidinium moieties near polar groups or bulk water. This unique capacity of Arg side chains to retain their charge in dehydrated environments likely contributes toward the important functional roles of internal Arg residues in situations where a charge is needed in the interior of a protein, in a lipid bilayer, or in similarly hydrophobic environments.
STRANGE YET STYLISH HEADGEAR VR consumption and the construction of gender

This article examines how gender is inscribed and reproduced in the consumption of Virtual Reality (VR) technologies. The focus is on how virtual reality systems become embedded in 'everyday life' through leisure and consumption, and how the spectacles and disciplines associated with consumption sites produce gendered virtual subjects. Studies of new communications technologies have tended to polarize between 'cyberpunk'/'cyberfeminist' visions of bodily transcendence in 'cyberspaces', and the critique of such visions from social theorists who focus on the reproduction of social and cultural inequalities through technical systems. These approaches tend to neglect the specific sites in which the social relations of VR are played out. A 'multi-sited' ethnographic study of immersive virtual reality systems is the basis for discussion of how virtual reality technologies produce gender in specific sites. Virtual systems are positioned and used differently in various locales such as arcades and art galleries, b.