Miracle-dz/UniFAR-FTUs huggingface dataset:
Host-Environment Interactions: Their Impact on Progression from Gastric Inflammation to Carcinogenesis and on Development of New Approaches to Prevent and Treat Gastric Cancer

Revelation of the connection between Helicobacter pylori infection and gastric adenocarcinoma has prompted new investigations pertaining to its basic and clinical aspects. H. pylori–induced persistent and uncontrolled gastric inflammation nearly always precedes the development of cancer and is instrumental in initiating a multistep process leading to carcinogenesis. Despite initial optimism about the potential of combination anti–H. pylori therapy to ultimately eradicate gastric adenocarcinoma, recent investigations suggest its use should be targeted and tailored to a selected patient group considering the multifaceted role of H. pylori in disease and the disease heterogeneity of gastric adenocarcinoma. The clinical spectrum of H. pylori infection ranges from asymptomatic gastritis and peptic ulcer to gastric malignancies. The occurrence of one versus another is the result of differences in the magnitude of gastritis, and the current disease paradigm suggests gastric inflammation is common to all H. pylori–associated gastroduodenal diseases. Therefore, the host inflammatory responses to environmental triggers, rather than to bacteria or environmental factors per se, would dictate the variable outcomes of H. pylori infection. Putative factors that are expected to play an important role in stimulating inflammatory pathways and modulating the cross-talk between host and environment are age at the time of infection, environmental cofactors, H. pylori virulence, and host genetics. Elucidation of the intimate relationship between host-environment interaction and gastric inflammation, although currently a formidable task, is essential in the development of new prevention and treatment strategies. Such knowledge might provide clues that allow more accurate prediction of variable outcomes of gastric inflammation and appropriate adjustment of treatment strategies, and might open up novel areas for studying gastric carcinogenesis. The evolving new technologies, such as microarray, proteomic, and functional genomic analyses, promise to shed new light on the immense complexity of the presumed host-environment interactions and will reveal more useful markers for the diagnosis and prognosis of gastric adenocarcinoma.
Experimental results of localization of moving underwater signal by adaptive beamforming

The problem of weak moving signal localization and tracking in the presence of single motionless strong interference is investigated using real data of an underwater experiment in the Baltic sea (Sept. 1990) with a horizontal receiving array of 64 hydrophones and with two independent powerful narrowband sources imitating the signal and interference. Three simple adaptive beamforming methods were employed for the experimental data processing. The first one is based on the well-known projection approach to adaptive beamforming, the second method uses the adaptive canceler approach (also termed the dipole pattern method), and the third method combines these approaches. The signal-to-interference power ratio (SIR) threshold of the signal localization and tracking is evaluated by a special technique, which allows examination of the considered algorithms with change of the SIR in consecutive order. The results of the data processing show the high possibilities of signal localization in the presence of strong interference. The combined method performs better than the methods considered and enables localization of the signal source up to an SIR/spl sime/-25 dB. >
The recursive form of error bounds for RFS state and observation with Pd < 1

In the target tracking and its engineering applications, recursive state estimation of the target is of fundamental importance. This paper presents a recursive performance bound for dynamic estimation and filtering problem, in the framework of the finite set statistics, for the first time. This performance limit is derived based on the meaningful distance error between two random sets, the target state set and its estimation. The estimation set is a function of the time-sequence of measurement sets. These measurement sets can be either empty or the Bernoulli random finite sets. Hence this bound can be applied when the probability of detection is less than unity. The state set model is a Markov process. The state set can be empty or not, which accounts for appearance and disappearance of the targets. Moreover, as a bound for discrete-time multidimensional filtering problems, it appears in recursive form. An application is presented to confirm the theory and reveal this bound is more general than previous bounds in the framework of random vector statistics.
Progress in modelling solidification microstructures in metals and alloys: dendrites and cells from 1700 to 2000

This is the first account of the history of our understanding of, and ability to model, solidification microstructures. Its objective is to retrace the scientific steps made, from the earliest observations of the eighteenth century to our present-day understanding of dendrites and eutectics. Because of the abundance of information, especially that added during the present century, sub-division was essential: this being the first of three articles. They cover dendrites and cells from 1700 to 2000, and then from 2001 to 2015 and finally eutectics and peritectics from 1700 to 2015. The authors have striven always to identify the genesis of every advance made, being aware that such a compact history must leave many worthy contributions by the wayside; others will doubtless complete the history. This review shows how cross-fertilisation between theory and experiment, and basic and applied research led to both the posing and answering of challenging fundamental questions, thus rewarding society with beneficial results.
Patellofemoral joint forces and stress during forward step-up, lateral step-up, and forward step-down exercises.

STUDY DESIGN Controlled laboratory study using a repeated-measures design. OBJECTIVE To quantify patellofemoral joint reaction force (PFJRF) and stress (PFJS) during forward step-up (FSU), lateral step-up (LSU), and forward step-down (FSD) exercises. BACKGROUND Although FSU, LSU, and FSD exercises are commonly used in patellofemoral joint rehabilitation programs, the influence of these stepping tasks on patellofemoral joint kinetics has not been quantified. METHODS Three-dimensional lower extremity kinematics and kinetics and electromyographic (EMG) data were obtained from 20 healthy adults during their performance of FSU, LSU, and FSD exercises. The step height for each participant was adjusted to permit a standardized knee flexion angle of 45°. A previously described biomechanical model of the patellofemoral joint was used to quantify PFJRF and PFJS during each task. Peak PFJRF and PFJS during the concentric and eccentric phases of each step task were compared using a 2-factor analysis of variance (ANOVA). RESULTS When collapsed across concentric and eccentric phases, peak PFJS was significantly greater during the FSD (mean ± SD, 13.8 ± 0.4 MPa) compared to the LSU (11.5 ± 0.8 MPa; P<.001) and FSU (11.2 ± 0.6 MPa; P = .002) exercises. Peak PFJRF also was significantly greater during the FSD (51.1 ± 2.7 N/kg) compared to the LSU (44.1 ± 3.4 N/kg; P<.001) and FSU (43.6 ± 2.3 N/kg; P = .023) exercises. CONCLUSION In selecting exercises that promote lower extremity muscle strengthening while minimizing patellofemoral joint loading, LSU and FSU should be considered over FSD exercises, if the same step height is used.
E74‐like factor 3 and nuclear factor‐κB regulate lipocalin‐2 expression in chondrocytes

E74‐like factor 3 (ELF3) is a transcription factor regulated by inflammation in different physio‐pathological situations. Lipocalin‐2 (LCN2) emerged as a relevant adipokine involved in the regulation of inflammation. In this study we showed for the first time the involvement of ELF3 in the control of LCN2 expression and its cooperation with nuclear factor‐κB (NFκB). Our results will help to better understand of the role of ELF3, NFκB and LCN2 in the pathophysiology of articular cartilage.
Inflammation and epigenetic regulation in osteoarthritis

ABSTRACT Osteoarthritis (OA) was once defined as a non-inflammatory arthropathy, but it is now well-recognized that there is a major inflammatory component to this disease. In addition to synovial cells, articular chondrocytes and other cells of diarthrodial joints are also known to express inflammatory mediators. It has been proposed that targeting inflammation pathways could be a promising strategy to treat OA. There have been many reports of cross-talk between inflammation and epigenetic factors in cartilage. Specifically, inflammatory mediators have been shown to regulate levels of enzymes that catalyze changes in DNA methylation and histone structure, as well as alter levels of non-coding RNAs. In addition, expression levels of a number of these epigenetic factors have been shown to be altered in OA, thereby suggesting potential interplay between inflammation and epigenetics in this disease. This review provides information on inflammatory pathways in arthritis and summarizes published research on how epigenetic regulators are affected by inflammation in chondrocytes. Furthermore, we discuss data showing how altered expression of some of these epigenetic factors can induce either catabolic or anti-catabolic effects in response to inflammatory signals. A better understanding of how inflammation affects epigenetic factors in OA may provide us with novel therapeutic strategies to treat this condition.
Somatotype Variables Related to Muscle Torque and Power in Judoists

Somatotype Variables Related to Muscle Torque and Power in Judoists The purpose of this study was to examine the relationship between somatotype, muscle torque and power output in judoists. Thirteen judoists (age 18.4±3.1 years, body height 178.6±8.2 cm, body mass 82.3±15.9 kg) volunteered to participate in this study. Somatotype was determined using the Heath-Carter method. Maximal muscle torques of elbow, shoulder, knee, hip and trunk flexors as well as extensors were measured under static conditions. Power outputs were measured in 5 maximal cycle ergometer exercise bouts, 10 s each, at increasing external loads equal to 2.5, 5.0, 7.5, 10.0 and 12.5% of body weight. The Pearson's correlation coefficients were calculated between all parameters. The mean somatotype of judoists was: 3.5-5.9-1.8 (values for endomorphy, mesomorphy and ectomorphy, respectively). The values (mean±SD) of sum of muscle torque of ten muscle groups (TOTAL) was 3702.2±862.9 N × m. The power output ranged from 393.2±79.4 to 1077.2±275.4 W. The values of sum of muscle torque of right and left upper extremities (SUE), sum of muscle torque of right and left lower extremities (SLE), sum of muscle torque of the trunk (ST) and TOTAL were significantly correlated with the mesomorphic component (0.68, 0.80, 0.71 and 0.78, respectively). The ectomorphic component correlated significantly with values of SUE, SLE, ST and TOTAL (-0.69, -0.81, -0.71 and -0.79, respectively). Power output was also strongly correlated with both mesomorphy (positively) and ectomorphy (negatively). The results indicated that the values of mesomorphic and ectomorphic somatotype components influence muscle torque and power output, thus body build could be an important factor affecting results in judo.
Processing and properties of highly porous Ti6Al4V mimicking human bones

Ti6Al4V alloy samples with large pores suitable for bone implants are fabricated by pressing and sintering. Ti6Al4V powder is mixed with different volume fractions of salt particles. The sintering behavior up to 1260 °C is studied by dilatometry and pore features are observed by scanning electron microscopy and X-ray microtomography. Sintered materials with a relative density between 0.26 and 0.97 are obtained. 3D image analysis proves that large pores form a connected network when the amount of salt is 20% and above. The Young’s modulus and the yield stress of sintered materials deduced from compression tests span over wide ranges of values, which are consistent with real bone data. A simple analytical model is proposed to estimate the relative density as a function of the fraction of salt. This model combined with classical Gibson and Ashby’s power equations for mechanical properties can predict the fraction of salt required to obtain prescribed properties.
Phonological Variant Recognition: Representations and Rules

The current research explores the role of lexical representations and processing in the recognition of phonological variants. Two alternative approaches for variant recognition are considered: a representational approach that posits frequency-graded lexical representations for variant forms and inferential processes that mediate between the spoken variant and the lexical representation. In a lexical decision task (Experiment 1) and in a phoneme identification task (Experiment 2) using real words, low-frequency variants, but not high-frequency variants, show improved recognition rates following additional experience with the variants. This knowledge generalized to novel variant forms. Experiment 3 replicated these results using an artificial lexicon and showed that recognition of low-frequency variants was influenced by similarity to a high-frequency variant form. Similarity to a high-frequency variant alone, however, was insufficient to explain recognition of the infrequent variants (Experiments 4 and 5). The results support a hybrid account of variant recognition that relies on both multiple frequency-graded representations and inference processes.
Double dissociation between syntactic gender and picture naming processing: A brain stimulation mapping study

Neural foundations of syntactic gender processing remain poorly understood. We used electrostimulation mapping in nine right‐handed awake patients during surgery for a glioma within the left hemisphere, to study whether the cortico‐subcortical structures involved in naming versus syntactic gender processing are common or distinct. In French, the article determines the grammatical gender. Thus, the patient was asked to perform a picture naming task and to give the appropriate article for each picture, with and without stimulation. Cortical stimulation elicited reproducible syntactic gender disturbances in six patients, in the inferior frontal gyrus (three cases), and in the posterior middle temporal gyrus (three cases). Interestingly, no naming disorders were generated during stimulation of the syntactic sites, while cortical areas inducing naming disturbances never elicited grammatical gender errors when stimulated. Moreover, at the subcortical level, stimulation of the white matter lateral to the caudate nucleus induced gender errors in three patients, with no naming disorders. Using cortico‐subcortical electrical mapping in awake patients, we demonstrate for the first time (1) a double dissociation between syntactic gender and naming processing, supporting independent network model rather than serial theory, (2) the involvement of the left inferior frontal gyrus, especially the pars triangularis, and the posterior left middle temporal gyrus in grammatical gender processing, (3) the existence of white matter pathways, likely a sub‐part of the left superior longitudinal fasciculus, underlying a large‐scale distributed cortico‐subcortical circuit which might selectively sub‐serve syntactic gender processing, even if interconnected with parallel sub‐networks involved in naming (semantic and phonological) processing. Hum Brain Mapp, 2011. © 2010 Wiley‐Liss, Inc.
The Therapeutic CD38 Monoclonal Antibody Daratumumab Induces Programmed Cell Death via Fcγ Receptor–Mediated Cross-Linking

Emerging evidence suggests that FcγR-mediated cross-linking of tumor-bound mAbs may induce signaling in tumor cells that contributes to their therapeutic activity. In this study, we show that daratumumab (DARA), a therapeutic human CD38 mAb with a broad-spectrum killing activity, is able to induce programmed cell death (PCD) of CD38+ multiple myeloma tumor cell lines when cross-linked in vitro by secondary Abs or via an FcγR. By comparing DARA efficacy in a syngeneic in vivo tumor model using FcRγ-chain knockout or NOTAM mice carrying a signaling-inactive FcRγ-chain, we found that the inhibitory FcγRIIb as well as activating FcγRs induce DARA cross-linking–mediated PCD. In conclusion, our in vitro and in vivo data show that FcγR-mediated cross-linking of DARA induces PCD of CD38-expressing multiple myeloma tumor cells, which potentially contributes to the depth of response observed in DARA-treated patients and the drug’s multifaceted mechanisms of action.
Triple antithrombotic therapy in patients with atrial fibrillation undergoing percutaneous coronary intervention: a viewpoint

Patients undergoing percutaneous coronary intervention (PCI) are treated with dual antiplatelet therapy to reduce the risk of subsequent myocardial infarction (MI) and stent thrombosis. Approximately 5-10% of patients undergoing PCI also have atrial fibrillation (AF). Patients with AF have an additional requirement for anticoagulation, as dual antiplatelet therapy alone is insufficient to adequately reduce the risk of stroke in patients with AF. However, it is now well established that combining anticoagulants with dual antiplatelet therapy also causes a significant increase in the risk of bleeding. Hence, there is great interest in discovering the optimal blend of antiplatelet therapy and oral anticoagulation in this situation, aiming to reduce the risk of stent thrombosis, recurrent MI, and stroke, while also minimizing the risk of bleeding. Recent studies have experimented with combining oral anticoagulation with a single antiplatelet agent, rather than combining oral anticoagulation with dual antiplatelet therapy. These studies show that this reduces the risk of bleeding but are underpowered to determine whether this still provides as much cardiovascular benefit. This review summarizes the currently available evidence on this topic and highlights the key questions that remain to be answered including ongoing clinical trials in the field.
Viruses, Autophagy Genes, and Crohn’s Disease

The etiology of the intestinal disease Crohn’s disease involves genetic factors as well as ill-defined environmental agents. Several genetic variants linked to this disease are associated with autophagy, a process that is critical for proper responses to viral infections. While a role for viruses in this disease remains speculative, accumulating evidence indicate that this possibility requires serious consideration. In this review, we will examine the three-way relationship between viruses, autophagy genes, and Crohn’s disease and discuss how host-pathogen interactions can mediate complex inflammatory disorders.
Special Issue on MC-SS A low complex receiver with interference cancellation for power-controlled MC-CDMA downlink transmissions

We consider the downlink of a power-controlled MC-CDMA system in which the near-far effect limits the performance of single-user receivers and calls for interference cancellation (IC)-based schemes. The latter provide enhanced error rate performance but are not suited for downlink applications due to their relatively large complexity. To overcome this problem, we present a novel reduced-complexity IC-based detector in which interfering signals are canceled provided that their estimated power exceeds a given threshold. In addition to the channel response, the proposed scheme requires knowledge of the amplitudes of the users' signals. The latter are estimated using two different methods that exploit some pilot blocks placed at the beginning of the downlink frame. Numerical results are given to highlight the effectiveness of the proposed scheme and to make comparisons with other existing IC-based solutions. Copyright © 2006 AEIT.
Implementation of RFID and Bluetooth Technology for Data Tagging and Transmission to Point of Sale

The design of wireless technology which involves radio frequency identiflcation (RFID) and Bluetooth technology for tagging and transmission of data that will be applied to point of sale (POS) is presented. A complete POS circuitry system has been designed to allow certain item to be a tag easily identifled and localized. This is implemented by using RFID technology which will communicate with personal computer (PC) either through Ethernet or Wifl connection. An Impinj RFID reader and Bluetooth mobile phone are selected in the proposed POS system. Matlab simulation has been performed for RFID transceiver part and Bluetooth data transmission. A prototype software is developed to interface the Impinj RFID reader through the Ethernet connection. Additionally, a data encryption from Bluetooth is paired with PC to achieve a secure and simple pairing feature when customer transaction is performed. It involves hardware and software implementation. Moreover, in simulation result, a double side band modulation is used to design the RFID reader for better item tagging. The results show the feasibility of using this design for POS and achieving very good read ranges. Finally, Bluetooth system enables fast transaction and makes purchase securely by using the proposed asymmetric algorithm.
Using Cartesian Space in Motion Planning for 7 DoF ManipulatorNutzung des kartesischen Raums in der Bewegungsplannung für Manipulatoren mit 7 Freiheitsgraden

Abstract This paper introduces motion planning algorithms that are suitable for real-time applications with dexterous manipulators. Developed motion planner obtains needed efficiency by using the Cartesian space information, and therefore avoids the dimensionality problem of the configuration space. In this work, a skillful planner is developed together with a post-processing path-smoothing technique, which is independent from the planner. A comparison with the state-of-the-art planners emphasises the advantages of this approach. Described algorithms successfully operate on a rehabilitation robotic system FRIEND.
Small Wind Turbine Testing and Applications Development September

NOTICE This report was prepared as an account of work sponsored by an agency of the United States government. Neither the United States government nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States government or any agency thereof. The views and opinions of authors expressed herein do not necessarily state or reflect those of the United States government or any agency thereof.
Varying-sampling-time LPV control for rejecting harmonically related nonstationary multisine disturbances

In this paper, a novel approach to design linear parameter-varying (LPV) controllers with time-varying sampling time to reject nonstationary harmonically related multisine disturbances is presented. The sampling time is chosen as a fraction of the smallest period of the harmonically related disturbance component. The plant is discretized with this sampling time using zero-order hold (ZOH). As a result, the disturbance model is regarded as one with fixed state-space representation subject to a time-varying sampling time. A polytopic LPV (pLPV) controller which quadratically stabilizes the plant under the disturbance is obtained. The number of the scheduling parameters is determined by the precision of the Taylor approximation for the discretized plant, independently of the number of frequencies. Excellent disturbance rejection is achieved in simulation.