Miracle-dz/UniFAR-FTUs huggingface dataset:
Secreted Glypican Binds to the Amyloid Precursor Protein of Alzheimer's Disease (APP) and Inhibits APP-induced Neurite Outgrowth*

The amyloid precursor protein (APP) of Alzheimer's disease has been shown to stimulate neurite outgrowth in vitro. The effect of APP on neurite outgrowth can be enhanced if APP is presented to neurons in substrate-bound form, in the presence of heparan sulfate proteoglycans. To identify specific heparan sulfate proteoglycans that bind to APP, conditioned medium from neonatal mouse brain cells was subjected to affinity chromatography with recombinant APP695 as a ligand. Glypican bound strongly to the APP affinity column. Purified glypican bound to APP with an equilibrium dissociation constant of 2.8 nM and inhibited APP-induced neurite outgrowth from chick sympathetic neurons. The effect of glypican was specific for APP, as glypican did not inhibit laminin-induced neurite outgrowth. Furthermore, treatment of cultures with 4-methylumbelliferyl-β-D-xyloside, a competitive inhibitor of proteoglycan glycanation, inhibited APP-induced neurite outgrowth but did not inhibit laminin-induced neurite outgrowth. This result suggests that endogenous proteoglycans are required for substrate-bound APP to stimulate neurite outgrowth. Secreted glypican may act to inhibit APP-induced neurite outgrowth in vivo by competing with endogenous proteoglycans for binding to APP.
Faster Convergence Rates of Relaxed Peaceman-Rachford and ADMM Under Regularity Assumptions

In this paper, we provide a comprehensive convergence rate analysis of the Douglas-Rachford splitting (DRS), Peaceman-Rachford splitting (PRS), and alternating direction method of multipliers (ADMM) algorithms under various regularity assumptions including strong convexity, Lipschitz differentiability, and bounded linear regularity. The main consequence of this work is that relaxed PRS and ADMM automatically adapt to the regularity of the problem and achieve convergence rates that improve upon the (tight) worst-case rates that hold in the absence of such regularity. All of the results are obtained using simple techniques.
A − 137 dBm/Hz Noise, 82% Efficiency AC-Coupled Hybrid Supply Modulator With Integrated Buck-Boost Converter

This paper presents a hybrid supply modulator (SM) with a comprehensive analysis of receiver (RX) band noise in an envelope tracking power amplifier (ET-PA). The designed SM supports both ET mode and average power tracking (APT) mode depending on the PA output power level. In the APT mode, an integrated buck-boost (BB) converter with hysteretic control generates dc supply voltage and its average switching frequency ranges from 1 to 2 MHz. In the ET mode, the bandwidth of SM is determined by a linear amplifier, which has about 30 MHz of signal bandwidth. To improve the ET efficiency, an ac coupling capacitor, with an adaptive offset control, and scaled linear supply are used. The scaled linear supply is provided by the BB converter. To lower the output noise of the SM, a parallel class-AB output buffer and resonance frequency tuning schemes are applied in this paper. For long term evolution 10 MHz with quadrature phase shift keying modulation and 5.8 dB peak-to-average power ratio, the designed SM achieves 82% efficiency at 800 mW output power with a fixed 8 Ω resistor. Adapting the proposed SM to a PA, a 10 dB ET operation dynamic range is achieved while achieving a power added efficiency of 42.6% at 27 dBm PA output power. The measured SM output noise is -137 dBm/Hz at 95 MHz offset with the PA load, and the PA RX band noise is -124 dBm/Hz, which is dominated by the stand-alone PA itself. The chip is implemented with a 130 nm CMOS process and the die size is 5.0 mm2.
National Provider Identifier (NPI) planning and implementation fundamentals for providers and payers.

Federal HIPAA legislation mandates that the National Provider Identifier (NPI) be fully implemented across all healthcare entities between May 2005 and May 2007, or 2008 for small payers. Starting May 2005, healthcare providers will be eligible to obtain an NPI and use these numbers to submit claims or conduct other transactions specified by HIPAA. By 2007, the NPI must be used in connection with the electronic transactions identified in HIPAA. Today, individual payers assign unique identification numbers to healthcare providers, and, in most cases, payers assign multiple identification numbers to healthcare providers and their "subparts. " As a result, providers have multiple payer-specific identification numbers. The NPI is a unique, 10-digit federal healthcare provider identification number that will be used by all healthcare providers and payers and other healthcare entities involved in administrative and financial transactions associated with health service events and related activities. This article will use software and data experts' knowledge as well as the authors' NPI implementation readiness assessment work to review the impact to both payers and providers, including hospitals, clinics, and other service entities. The authors will suggest planning, budgeting, architecting, and data management solutions for payers and providers to achieve the optimal administrative simplification goals intended by the NPI, without compromising data integrity and interoperability objectives across the service spectrum of the healthcare enterprise.
Use of Aversive and Restrictive Interventions in Behavioral Treatment

This article addresses the educational, therapeutic, and scienti ic context within which aversive and restrictive procedures should be used and evaluated if indeed they are employed. The guidelines proposed center on (a) the importance of informing the clients’ parents and relatives, as well as the community, (b) the importance of providing staff training in how to apply nonaversive interventions, (c) the need for supervision by quali ied colleagues as in peer-review, and (d) the need to take objective data to evaluate the positive and negative effects of aversive interventions, including long-term follow-ups. The article also discusses some similarities and differences between guidelines typically proposed by behavior analysts, and Norwegian regulations of aversive and restrictive methods. We thank Tris Smith for thoughtful comments on previous versions of this manuscript.
Adaptive header compression for wireless networks

TCP/IP header compression has long been used to send information efficiently and to improve the response time of communication systems. It is also well known that errors on the link where header compression is used can deteriorate the performance. In addition, the previously noticed high frequency of some computer networking problems can make the performance of header compression even worse. These problems include packet reordering and packet errors that avoid link layer error detection. We analyze the influence of these problems on existing header compression algorithms. We also propose an adaptive header compression that gives better performance.
Older adults’ performance on the speech, spatial, and qualities of hearing scale (SSQ): Test-retest reliability and a comparison of interview and self-administration methods

Abstract The purposes of the study were to examine the test-retest properties of the speech, spatial, and qualities of hearing scale (SSQ) and to determine if the method of test administration affected these properties. Four groups of 40 older adult participants completed the SSQ twice at an interval of about a half year, using either the same or different administration methods at the two test times. The SSQ was administered using an interview method and/or it was self-administered and then returned by mail. Although the method of test administration did not systematically affect scores on the SSQ, the highest test-retest correlation (r = 0.83) was observed using the interview method at both test times, making it the best choice for the purpose of demonstrating the effectiveness of interventions. The other three combinations of dual-administration in this study also provided reliable results and may be preferable because the self-administration method is less time-consuming and labour-intensive. In conclusion, both the interview and self-administration methods are recommended, but with the best choice depending on the goals of the tester. Sumario El propósito de este estudio fue examinar las propiedades test-retest de la escala de audición del habla, espacial y de cualidades (SSQ) y determinar si el método de administración de la prueba afecta esas propiedades. Cuatro grupos de 40 participantes adultos mayores completaron el SSQ dos veces con un intervalo de cerca de medio año, usando (tanto) el mismo o un diferente método de administración en los dos tiempos de la prueba. El SSQ se administró usando un método de entrevista y/o por la auto aplicación y luego, enviado por correo. No obstante que el método de administración de la prueba no afectó sistemáticamente las puntuaciones del SSQ, la mayor correlación test-retest (r = 0.83) se observó usando el método de entrevista en los dos tiempos de la prueba, haciendo de él la mejor selección para demostrar la efectividad de las intervenciones. Las otras tres combinaciones de la administración doble en este estudio, dieron resultados confiables y pueden ser preferibles, porque el método de auto aplicación consume menos tiempo y requiere menor trabajo intensivo. En conclusión, se recomiendan tanto los métodos de entrevista como el de auto aplicación, pero la mejor selección dependerá de las metas del examinador.
The Positive Project Team - The Impact of Positive Affectivity on Project Success.

What is the impact of positive affectivity on project success? The primary purpose of this paper is to answer that question by comparing two project groups based on their psychological traits and attitudes and see whether it has an influence on project success. It is done by administering psychometric tests, Life Orientation Test-Revised (LOT-R) and Positive and Negative Affect Schedule (PANAS) to both groups, along with questions regarding group dynamic based on positive psychology. Do their views affect how they experience the group dynamic? We find that there are some differences between the groups. Group A is both more optimistic and higher on the positive affect scale than group B. In compliment with this group A is also lower on the negative affect scale. Group A is more open to change, responsibility and roles are clearer and there is more happiness within the group. The sponsors of the projects confirm that positivity is higher in group A and based on the sponsors definition of success there is a reason to belief that positive affectivity translates into greater success of the project. The main findings in this research indicate that a mind-set of optimism and positive affectivity can have a positive effect on project success.
Layered graph Data Model for dataspaces management

In order to improve management of heterogeneous data sources in dataspace, a unified data model to represent all kinds of data in a single, powerful and simple way is the foundation of dataspace system. We propose a layered graph Data Model (lgDM) namely entity data graph (GD) and entity schema graph (GS) to describe and capture associations among entities and entity classes. We propose an association mining strategy and a graph weighting scheme to facilitate keyword query and query results ranking. We conduct experiments to demonstrate the feasibility and functionality of our proposed data model.
Reply to John Searle's Conjunctive Conditions for Non-defective Promising

John Searle’s Speech Act Theory enumerates necessary and sufficient conditions for a non-defective act of promising in producing sincere promises. This paper seeks to demonstrate the conjunctive insufficiency of the foregoing conditions due to the inadequacy of the sincerity condition to guarantee predicated acts being fulfillable. Being the definitive condition which contains the psychological state distinct in promises as illocutionary acts, that is the expression of intention (S intends to A), I purport that not all sincere promises are non-defective. To motivate this, I shall explicate Searle’s conception of full blown explicit promises as his basic qualification for the application of the above conditions, and set the line as to how explicit is ‘explicit’? As a response to this insufficiency, I shall propose a condition, as part and parcel of the Propositional Content Clause, that makes up Searle’s felicity conditions for promises, which requires explicitness of the form: “A is fulfillable if A is explicit in form”. A is explicit if and only if 1) A is literal in form, where A can have either 1 basic or multiple meanings, and 2) The meaning of A, whether basic or multiple, with respect to its context is directly stated in the sentence uttered. I call this the Discharge Condition.
Abdominal Visceral and Subcutaneous Adipose Tissue Compartments: Association With Metabolic Risk Factors in the Framingham Heart Study

Background— Visceral adipose tissue (VAT) compartments may confer increased metabolic risk. The incremental utility of measuring both visceral and subcutaneous abdominal adipose tissue (SAT) in association with metabolic risk factors and underlying heritability has not been well described in a population-based setting. Methods and Results— Participants (n=3001) were drawn from the Framingham Heart Study (48% women; mean age, 50 years), were free of clinical cardiovascular disease, and underwent multidetector computed tomography assessment of SAT and VAT volumes between 2002 and 2005. Metabolic risk factors were examined in relation to increments of SAT and VAT after multivariable adjustment. Heritability was calculated using variance-components analysis. Among both women and men, SAT and VAT were significantly associated with blood pressure, fasting plasma glucose, triglycerides, and high-density lipoprotein cholesterol and with increased odds of hypertension, impaired fasting glucose, diabetes mellitus, and metabolic syndrome (P range <0.01). In women, relations between VAT and risk factors were consistently stronger than in men. However, VAT was more strongly correlated with most metabolic risk factors than was SAT. For example, among women and men, both SAT and VAT were associated with increased odds of metabolic syndrome. In women, the odds ratio (OR) of metabolic syndrome per 1–standard deviation increase in VAT (OR, 4.7) was stronger than that for SAT (OR, 3.0; P for difference between SAT and VAT <0.0001); similar differences were noted for men (OR for VAT, 4.2; OR for SAT, 2.5). Furthermore, VAT but not SAT contributed significantly to risk factor variation after adjustment for body mass index and waist circumference (P ≤0.01). Among overweight and obese individuals, the prevalence of hypertension, impaired fasting glucose, and metabolic syndrome increased linearly and significantly across increasing VAT quartiles. Heritability values for SAT and VAT were 57% and 36%, respectively. Conclusions— Although both SAT and VAT are correlated with metabolic risk factors, VAT remains more strongly associated with an adverse metabolic risk profile even after accounting for standard anthropometric indexes. Our findings are consistent with the hypothesized role of visceral fat as a unique, pathogenic fat depot. Measurement of VAT may provide a more complete understanding of metabolic risk associated with variation in fat distribution.
Generation of linear cartesian trajectories for robots using industrial motion-controllers

The paper focuses on the problem of Cartesian trajectory generation for manipulators. The proposed solution relies on the computation of spline coefficients both in the Cartesian and joint spaces. The method takes into account motor capabilities by checking maximum velocity and acceleration constraints. The solution was experimentally verified on a novel manipulator with hybrid, parallel-serial kinematic structure.
The Arabidopsis DELLA RGA-LIKE3 Is a Direct Target of MYC2 and Modulates Jasmonate Signaling Responses[C][W]

The DELLA proteins function as negative regulators of the gibberellin (GA) signaling pathway. This article reports that RGL3 is a distinct DELLA protein that acts as an integrating factor that links GA and jasmonate signaling to enable adaptive regulation of plant resistance to pathogens. Gibberellins (GAs) are plant hormones involved in the regulation of plant growth in response to endogenous and environmental signals. GA promotes growth by stimulating the degradation of nuclear growth–repressing DELLA proteins. In Arabidopsis thaliana, DELLAs consist of a small family of five proteins that display distinct but also overlapping functions in repressing GA responses. This study reveals that DELLA RGA-LIKE3 (RGL3) protein is essential to fully enhance the jasmonate (JA)-mediated responses. We show that JA rapidly induces RGL3 expression in a CORONATINE INSENSITIVE1 (COI1)– and JASMONATE INSENSITIVE1 (JIN1/MYC2)–dependent manner. In addition, we demonstrate that MYC2 binds directly to RGL3 promoter. Furthermore, we show that RGL3 (like the other DELLAs) interacts with JA ZIM-domain (JAZ) proteins, key repressors of JA signaling. These findings suggest that JA/MYC2-dependent accumulation of RGL3 represses JAZ activity, which in turn enhances the expression of JA-responsive genes. Accordingly, we show that induction of primary JA-responsive genes is reduced in the rgl3-5 mutant and enhanced in transgenic lines overexpressing RGL3. Hence, RGL3 positively regulates JA-mediated resistance to the necrotroph Botrytis cinerea and susceptibility to the hemibiotroph Pseudomonas syringae. We propose that JA-mediated induction of RGL3 expression is of adaptive significance and might represent a recent functional diversification of the DELLAs.
A new approach to instruction-idioms detection in a retargetable decompiler

Retargetable executable-code decompilation is a one of the most complicated reverse-engineering tasks. Among others, it involves de-optimization of compiler-optimized code. One type of such an optimization is usage of so-called instruction idioms. These idioms are used to produce faster or even smaller executable files. On the other hand, decompilation of instruction idioms without any advanced analysis produces almost unreadable high-level language code that may confuse the user of the decompiler. In this paper, we revisit and extend the previous approach of instruction-idioms detection used in a retargetable decompiler developed within the Lissom project. The previous approach was based on detection of instruction idioms in a very-early phase of decompilation (a front-end part) and it was inaccurate for architectures with a complex instruction set (e.g. Intel x86). The novel approach is based on delaying detection of idioms and reconstruction of code to the later phase (a middleend part). For this purpose, we use the LLVM optimizer and we implement this analysis as a new pass in this tool. According to experimental results, this new approach significantly outperforms the previous approach as well as the other commercial solutions.
An Investigation of the Surface Properties of (Ag,Cu)(In,Ga)Se $_{\bf 2}$ Thin Films

(Ag,Cu)(In,Ga)Se2 alloy absorber layers with various Ga/(Ga+In) and Ag/(Ag+Cu) ratios were deposited using multisource elemental evaporation and analyzed by glancing incidence X-ray diffraction and energy dispersive X-ray spectroscopy. All films exhibit chalcopyrite reflections in the X-ray diffraction pattern and films with 0.5 ≤ Ga/(Ga+In) <; 1 and Ag/(Ag+Cu) >; 0.5 have additional reflections consistent with an ordered defect phase which is limited to the near-surface region of the film. X-ray photoelectron spectroscopy measurements show that all films studied have low (Ag+Cu)/Se and (Ag+Cu)/(Ga+In) ratios near the surface relative to the bulk composition, consistent with an ordered defect compound identified as (Ag,Cu)(In,Ga)5Se8. Additionally, the near-surface region of (Ag,Cu)(In,Ga)Se2 films contains a higher Ag/(Ag+Cu) ratio than the bulk and the Ag(In,Ga)Se2 film contains excess Ag near the surface.
Search Behavior of International Vacationers: Travel-Specific Lifiestyle and Sociodemographic Variables

The primary objectives of this exploratory study were to determine the relative ability of a limited number of travel-specific psychographic statements and sociodemographic variables to (1) predict and explain external search behavior of a sample of international vacationers and (2) discriminate between respondents exemplifying active and passive external search behavior. The findings suggest that search behavior is better explained by travel-specific psychographics than by demographics.
Cancer Chemoprevention by Citrus Pulp and Juices Containing High Amounts of β-Cryptoxanthin and Hesperidin

β-Cryptoxanthin, a carotenoid, and hesperidin, a flavonoid, possess inhibitory effects on carcinogenesis in several tissues. We recently have prepared a pulp (CHRP) and citrus juices (MJ2 and MJ5) from a satsuma mandarin (Citrus unshiu Mar.) juice (MJ). They contain high amounts of β-cryptoxanthin and hesperidin. We have demonstrated that CHRP and/or MJs inhibit chemically induced rat colon, rat tongue, and mouse lung tumorigenesis. Gavage with CHRP resulted in an increase of activities of detoxifying enzymes in the liver, colon, and tongue rats'. CHRP and MJs were also able to suppress the expression of proinflammatory cytokines and inflammatory enzymes in the target tissues. This paper describes the findings of our in vivo preclinical experiments to develop a strategy for cancer chemoprevention of colon, tongue, and lung neoplasms by use of CHRP and MJs.
Perceptual wavelet packet audio coder

Traditional wavelet packet audio compression algorithms do not utilize the temporal masking properties of the human auditory system, relying instead on simultaneous masking models. This paper presents the design and implementation of a perceptual wavelet audio coder by incorporating temporal and simultaneous masking models. The efficiency of the encoder was assessed based upon the number of bits required to code wavelet packet coefficients in each critical band, while retaining perceptual transparency. Subjective listening tests conforming to ITU-R BS.1116 revealed the bit rate is reduced by more than 17% compared to using a coder that only employs a simultaneous masking model.
Foundations of uncertain-data integration

There has been considerable past work studying data integration and uncertain data in isolation. We develop the foundations for local-as-view (LAV) data integration when the sources being integrated are uncertain. We motivate two distinct settings for uncertain-data integration. We then define containment of uncertain databases in these settings, which allows us to express uncertain sources as views over a virtual mediated uncertain database. Next, we define consistency of a set of uncertain sources and show intractability of consistency-checking. We identify an interesting special case for which consistency-checking is polynomial. Finally, the notion of certain answers from traditional LAV data integration does not generalize to the uncertain setting, so we define a corresponding notion of correct answers.
Alternative medicine and the Internet.

WHAT IS ALTERNATIVE MEDICINE? Alternative medicine (AM) can be defined as any health care remedy or system that is not generally accepted in modern biomedicine, or therapies that are offered in place of or as substitutes for conventional therapies (1). Alternative therapies include the following: folk medicine, herbal medicine, diet fads, homeopathy, faith healing, Ayurvedic medicine, chiropractic, acupuncture, naturopathy, massage and music therapy. Allopathic medicine is the term used to refer to mainstream medical practice.