Miracle-dz/UniFAR-FTUs huggingface dataset:
Mushrooms as Possible Antioxidant and Antimicrobial Agents

The aim of the study is to examine in-vitro antioxidant and antimicrobial activity of the acetonic and methanolic extracts of the mushrooms Boletus aestivalis, Boletus edulis and Leccinum carpini. Antioxidant activity was evaluated by using free radical scavenging activity and reducing power. In addition, total content of phenol and flavonoid in extracts were determined as pyrocatechol equivalent, and as rutin equivalent, respectively. As a result of the study acetonic extracts from Boletus edulis was more powerful antioxidant activity with IC50 value of 4.72 μg/mL which was similar or greater than the standard antioxidants, ascorbic acid (IC50 = 4.22 μg/mL), BHA (IC50 = 6.42 μg/mL) and α-tocopherol (IC50 = 62.43 μg/mL). Moreover, the tested extracts had effective reducing power. A significant relationship between total phenolic and flavonoid contents and their antioxidative activities was significantly observed. The antimicrobial activity of each extract was estimated by determination of the minimum inhibitory concentration by using microdilution plate method against five species of bacteria and five species of fungi. Generally, the tested mushroom extracts had relatively strong antimicrobial activity against the tested microorganisms. The minimum inhibitory concentration for both extracts related to the tested bacteria and fungi were 1.25 - 10 mg/ mL. The present study shows that tested mushroom species demonstrated a strong antioxidant and antimicrobial activity. It suggests that mushroom may be used as good sources of natural antioxidants and for pharmaceutical purposes in treating of various deseases.
Joint interference alignment and IB-DFE scheme for MC-CDMA systems

Interference alignment (IA) is a promising technique that allows high capacity gains in interfering channels. On the other hand, iterative block decision feedback equalization (IB-DFE) based receivers can efficiently exploit the inherent space-frequency diversity of the MIMO MC-CDMA systems. In this paper we combine IA precoding at the transmitter with IB-DFE based processing at the receiver for MC-CDMA systems. The IA precoding is applied at chip level instead of the data symbols level. The receiver is designed in two steps: first an equalizer based on zero forcing (ZF) is used to remove the aligned users' interference, then and after a whitening noise process, an IB-DFE based equalizer is designed to remove the residual inter-carrier interference. Our proposed scheme achieves the maximum degrees of freedom provided by the IA precoding, while allowing a close-to-optimum diversity gain, with performance close to the matched filter bound (MFB).
Honesty, Dishonesty, and the Movement of Psychoanalytic Experience

r. Renik‘s personally rich and analytically evocative paper evinces the D dilemma of trying to understand the nuanced complexities of analytic engagement through the lens of independent constructs. Thus, the issue of honesty and dishonesty in the consulting room may be reversed as well: what becomes of the concepts of honesty and dishonesty when they are ground through the refining mill of analysis? Do they retain as much of their original meaning and character when processed through an actual analysis as they appear to have at the outset? Stated differently, an exploration of these questions may show the psychoanalytic process to be cap& ble of subsuming other ideas, but it itself may not be able to be comprehensively framed or subsumed within these other conceptual entities. A reason for this would appear to concern analysis’s dual character as a concrete living process within which its participants are directly and immediately engaged, as well as being a conceptual and more broadly theoretical schema that can be cognitively approached. Hence, our ideas about what analysis is, and thoughts about what it ideally should become, never seem to quite fit with what an actual analysis turns out to be, and our ideas about how to bring about more efficacious, democratic, and reflective treatments often wind up, when clinically prescribed and imposed, resulting in selfcontradictions and resistance to the process. We may become ensnared even in attempting to write about the process. Thus, Levenson (1980) has written that the analyst should not be the one who has to “know”; she or he should instead be more open to hearing what is going on. But how can one know this without being the one who knows? Philosophers, after a l l , aver that the eye cannot behold itself in the act of seeing. Thus, we cannot “know” that we should not try to know without contradicting ourselves.
Regulation of cellular genes transduced by herpes simplex virus

Previous studies demonstrated that the rabbit beta-globin gene is transcribed from its own promoter and regulated as a herpes simplex virus (HSV) early gene following insertion into the early HSV thymidine kinase gene in the intact viral genome (J. R. Smiley, C. Smibert, and R. D. Everrett, J. Virol. 61:2368-2377, 1987). We report here that the beta-globin promoter remained under early control after insertion into the late HSV gene encoding glycoprotein C. On the basis of these findings, we concluded that the beta-globin promoter is functionally equivalent to an HSV early-control region. We found that a transduced human alpha-globin gene was also regulated as an early HSV gene, while two linked Alu elements mimicked the behavior of HSV late genes. These results demonstrate that certain aspects of HSV temporal regulation can be duplicated by cellular elements and provide strong support for the hypothesis that the regulation of HSV gene expression can occur through mechanisms that do not rely on recognition of virus-specific temporal control signals.
CCL2 Responses to Mycobacterium tuberculosis Are Associated with Disease Severity in Tuberculosis

Background Leucocyte activating chemokines such as CCL2, CCL3, and CXCL8 together with proinflammatory IFNγ, TNFα and downmodulatory IL10 play a central role in the restriction of M. tuberculosis infections, but is unclear whether these markers are indicative of tuberculosis disease severity. Methodology We investigated live M. tuberculosis- and M. bovis BCG- induced peripheral blood mononuclear cell responses in patients with tuberculosis (TB) and healthy endemic controls (ECs, n = 36). TB patients comprised pulmonary (PTB, n = 34) and extrapulmonary groups, subdivided into those with less severe localized extrapulmonary TB (L-ETB, n = 16) or severe disseminated ETB (D-ETB, n = 16). Secretion of CCL2, IFNγ, IL10 and CCL3, and mRNA expression of CCL2, TNFα, CCL3 and CXCL8 were determined. Results M. tuberculosis- and BCG- induced CCL2 secretion was significantly increased in both PTB and D-ETB (p<0.05, p<0.01) as compared with L-ETB patients. CCL2 secretion in response to M. tuberculosis was significantly greater than to BCG in the PTB and D-ETB groups. M. tuberculosis-induced CCL2 mRNA transcription was greater in PTB than L-ETB (p = 0.023), while CCL2 was reduced in L-ETB as compared with D-ETB (p = 0.005) patients. M. tuberculosis –induced IFNγ was greater in L-ETB than PTB (p = 0.04), while BCG-induced IFNγ was greater in L-ETB as compared with D-ETB patients (p = 0.036). TNFα mRNA expression was raised in PTB as compared with L-ETB group in response to M. tuberculosis (p = 0.02) and BCG (p = 0.03). Mycobacterium-induced CCL3 and CXCL8 was comparable between TB groups. Conclusions The increased CCL2 and TNFα in PTB patients may support effective leucocyte recruitment and M. tuberculosis localization. CCL2 alone is associated with severity of TB, possibly due to increased systemic inflammation found in severe disseminated TB or due to increased monocyte infiltration to lung parenchyma in pulmonary disease.
Impact of Imperfections on Detectors for Interference Suppression

In this paper, we carry out the performance analysis of recently proposed low complexity max log MAP detector for interference suppression under the realistic imperfections of correlation and non Gaussian alphabets. We also incorporate MMSE detector in our analysis taking into account non Gaussian alphabets however intricacy in the analysis of correlated case restricts our analysis to the case of iid fading. Employing moment generating function(MGF)-based approach, we derive upper bounds of coded pairwise error probability (PEP) and study the effect of non Gaussian interference and correlation. The novelty of this contribution is the performance analysis taking into account discrete alphabets as the existing work is based on the unrealistic Gaussian assumption for these alphabets.
Effects of whole spine alignment patterns on neck responses in rear end impact

ABSTRACT Objective: The aim of this study was to investigate the whole spine alignment in automotive seated postures for both genders and the effects of the spinal alignment patterns on cervical vertebral motion in rear impact using a human finite element (FE) model. Methods: Image data for 8 female and 7 male subjects in a seated posture acquired by an upright open magnetic resonance imaging (MRI) system were utilized. Spinal alignment was determined from the centers of the vertebrae and average spinal alignment patterns for both genders were estimated by multidimensional scaling (MDS). An occupant FE model of female average size (162 cm, 62 kg; the AF 50 size model) was developed by scaling THUMS AF 05. The average spinal alignment pattern for females was implemented in the model, and model validation was made with respect to female volunteer sled test data from rear end impacts. Thereafter, the average spinal alignment pattern for males and representative spinal alignments for all subjects were implemented in the validated female model, and additional FE simulations of the sled test were conducted to investigate effects of spinal alignment patterns on cervical vertebral motion. Results: The estimated average spinal alignment pattern was slight kyphotic, or almost straight cervical and less-kyphotic thoracic spine for the females and lordotic cervical and more pronounced kyphotic thoracic spine for the males. The AF 50 size model with the female average spinal alignment exhibited spine straightening from upper thoracic vertebra level and showed larger intervertebral angular displacements in the cervical spine than the one with the male average spinal alignment. Conclusions: The cervical spine alignment is continuous with the thoracic spine, and a trend of the relationship between cervical spine and thoracic spinal alignment was shown in this study. Simulation results suggested that variations in thoracic spinal alignment had a potential impact on cervical spine motion as well as cervical spinal alignment in rear end impact condition.
Lysosomal putative RNA transporter SIDT2 mediates direct uptake of RNA by lysosomes

ABSTRACT Lysosomes are thought to be the major intracellular compartment for the degradation of macromolecules. We recently identified a novel type of autophagy, RNautophagy, where RNA is directly taken up by lysosomes in an ATP-dependent manner and degraded. However, the mechanism of RNA translocation across the lysosomal membrane and the physiological role of RNautophagy remain unclear. In the present study, we performed gain- and loss-of-function studies with isolated lysosomes, and found that SIDT2 (SID1 transmembrane family, member 2), an ortholog of the Caenorhabditis elegans putative RNA transporter SID-1 (systemic RNA interference deficient-1), mediates RNA translocation during RNautophagy. We also observed that SIDT2 is a transmembrane protein, which predominantly localizes to lysosomes. Strikingly, knockdown of Sidt2 inhibited up to ˜50% of total RNA degradation at the cellular level, independently of macroautophagy. Moreover, we showed that this impairment is mainly due to inhibition of lysosomal RNA degradation, strongly suggesting that RNautophagy plays a significant role in constitutive cellular RNA degradation. Our results provide a novel insight into the mechanisms of RNA metabolism, intracellular RNA transport, and atypical types of autophagy.
Opioid treatment for agitation in patients with advanced dementia

Some patients with advanced dementia cannot convey the experience of pain verbally and may react to pain with aggressive and agitated behaviors. We hypothesized that unrecognized pain could contribute to agitation and that low dose opioid therapy might reduce agitation by reducing pain. We therefore attempted to determine the effect of opioids on agitation in demented patients.
Injection of the Retinal Vascular System in the Enucleated Eye in Diabetic Retinopathy *

IN the course of our studies in diabetic retinopathy, a preliminary report of which was recently issued in this journal (Ashton, 1949), many methods of (lemonstrating the retinal vasculature have been tried, among wh,ich injection of the retinal capillaries in the excised eye with a variety of dyes and plastic materials has been attempted and is still being investigated. So far the use of Indian Ink has been found extremely effective and during the course of our work Michaelson and Steedman (1949) published a similar method for injecting the freshly enucleated eve and they have indicated the potentialities of this technique in anatomical and pathological studies. It is thought, therefore, that the publication of photographs of the injjected retina from a case of advanced diabetic retinopathv would be of timely interest. Our method varies in detail from thcat of MIichaelson and Steedmian.
Health risks from acid rain: a Canadian perspective.

Acidic deposition, commonly referred to as acid rain, is causing serious environmental damage in eastern Canada. The revenues from forest products, tourism and sport fishing are estimated to account for about 8% of the gross national product. The impact on human health is not as clearcut and a multi-department program on the Long-Range Transport of Airborne Pollutants (LRTAP) was approved by the federal government in June 1980. The objectives of the LRTAP program are to reduce wet sulfate deposition to less than 20 kg/ha per year in order to protect moderately sensitive areas. This will require a 50% reduction in Canadian SO2 emissions east of the Saskatchewan/Manitoba border and concomitant reductions in the eastern U.S.A. The objectives of the health sector of the program are to assess the risk to health posed by airborne pollutants which are subjected to long-range transport and to monitor the influence of abatement programs. Two major epidemiology studies were undertaken in 1983, one in which the health effects related to acute exposure to transported air pollutants were studied in asthmatic and nonasthmatic children, and another in which the effects of chronic exposure to these pollutants were studied in school children living in towns with high and low levels of pollutants. Preliminary analysis of the data do not indicate major health effects, but definitive conclusions must await final analysis. Studies on the indirect effects of acid deposition on water quality have shown that acidified lake water left standing in the plumbing system can adversely affect water quality and that federally set guidelines for copper and lead are exceeded. Flushing of the system before using the water rectifies the situation. Additional studies are planned to further delineate the magnitude of the health effects of acidified lake water. ImagesFIGURE 1.FIGURE 2.
Long term measurements of sulfur dioxide, nitrogen dioxide, ammonia, nitric acid and ozone in Africa using passive samplers

Abstract. In this paper we present the long term monitoring of ambient gaseous concentrations within the framework of the IDAF (IGAC-DEBITS-AFRICA) program. This study proposes for the first time an analysis of long-term inorganic gas concentrations (1998 to 2007) of SO2, NO2, HNO3, NH3 and O3, determined using passive samplers at seven remote sites in West and Central Africa. Sites are representative of several African ecosystems and are located along a transect from dry savannas-wet savannas-forests with sites at Banizoumbou (Niger), Katibougou and Agoufou (Mali), Djougou (Benin), Lamto (Cote d'Ivoire), Zoetele (Cameroon) and Bomassa (Congo). The strict control of measurement techniques as well as the validation and inter-comparison studies conducted with the IDAF passive samplers assure the quality and accuracy of the measurements. For each type of African ecosystem, the long term data series have been studied to document the levels of surface gaseous concentrations. The seasonal and interannual variability have also been analyzed as a function of emission source variations. We compared the measured West and Central African gas concentrations to results obtained in other parts of the world. Results show that the annual mean concentrations of NO2, NH3, HNO3 measured in dry savannas are higher than those measured in wet savannas and forests that have quite similar concentrations. Annual mean NO2 concentrations vary from 0.9±0.2 in forests to 2.4±0.4 ppb in the dry savannas, NH3 from 3.9±1.4 to 7.4±0.8 ppb and HNO3 from 0.2±0.1 to 0.5±0.2 ppb. Annual mean O3 and SO2 concentrations are lower for all ecosystems and range from 4.0±0.4 to 14.0±2.8 and from 0.3±0.1 to 1.0±0.2 ppb, respectively. A focus on the processes involved in gas emissions from dry savannas is presented in this work, providing explanations for the high concentrations of all gases measured at the three dry savannas sites. At these sites, seasonal concentrations of all gases are higher in the wet season. Conversely, concentrations are higher in the dry season in the wet savannas. In forested regions, we measure no significant difference between wet and dry seasons. This unique database of long term gases concentrations monitoring is available at: http://medias.obs-mip.fr/idaf/ .
How Does a Retailer's Service Plan Affect a Manufacturer's Warranty?

A service plan is a type of optional warranty beyond manufacturers' base warranties that retailers offer to consumers. In this paper, we examine how a service plan affects the role played by a manufacturer's base warranty. Analysis shows that when consumers can assess product quality (i.e., the probability of product failure), the manufacturer's warranty is negatively affected by the presence of a service plan. In the presence of such a plan, a base warranty is offered only when the manufacturer is very cost-efficient in providing a warranty relative to the retailer. In this case, although the double-marginalization problem is aggravated, offering a (limited) base warranty reduces the total warranty cost in the channel and provokes the retailer into enlarging the service plan coverage. When consumers cannot assess product quality, a high-quality manufacturer is motivated to offer a base warranty to signal its quality. In the presence of a service plan, however, a very cost-efficient manufacturer is discouraged from doing so. This paper was accepted by Preyas Desai, marketing.
Evaluating the Effect of Social Conversation on Learning , Interaction , and Perceived Interdependence in a Collaborative Math Problem Solving Environment

In this paper, we explore the effect of social prompts offered by a computer supported collaborative learning (CSCL) environment on student attitudes and behavior towards each other. We do this by experimentally contrasting collaboration in two configurations, one that presents students with social questions in between math problems and then uses the answers to those problems to tailor the cover story and associated hints for the next problem, and a control condition that uses the same problems, but does not use social questions for tailoring. Our finding is that the social prompts changed the attitude students displayed towards one another. Whereas in the control condition students took on a more competitive attitude, in the experimental condition students were more playful. On the questionnaire students reported exchanging more help in the experimental condition. An analysis of the corpus reveals no significant differences in amount of help exchanged, but there was a significant difference in terms of non-help-related conversation such that the proportion of episodes where help was provided was higher in the Experimental condition. In terms of learning gains, the trend was consistently in favor of the experimental condition in terms of learning between the pretest and the quizzes after each lab session as well as the posttest, however these trends were not statistically significant overall. The strongest learning result is that students in the experimental condition learned marginally more on one unit of the material on the second lab day than students in the control condition (p=.06, effect size .55 standard deviations).
Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC Trial.

BACKGROUND Sentinel lymph node biopsy in women with operable breast cancer is routinely used in some countries for staging the axilla despite limited data from randomized trials on morbidity and mortality outcomes. We conducted a multicenter randomized trial to compare quality-of-life outcomes between patients with clinically node-negative invasive breast cancer who received sentinel lymph node biopsy and patients who received standard axillary treatment. METHODS The primary outcome measures were arm and shoulder morbidity and quality of life. From November 1999 to October 2003, 1031 patients were randomly assigned to undergo sentinel lymph node biopsy (n = 515) or standard axillary surgery (n = 516). Patients with sentinel lymph node metastases proceeded to delayed axillary clearance or received axillary radiotherapy (depending on the protocol at the treating institution). Intention-to-treat analyses of data at 1, 3, 6, and 12 months after surgery are presented. All statistical tests were two-sided. RESULTS The relative risks of any lymphedema and sensory loss for the sentinel lymph node biopsy group compared with the standard axillary treatment group at 12 months were 0.37 (95% confidence interval [CI] = 0.23 to 0.60; absolute rates: 5% versus 13%) and 0.37 (95% CI = 0.27 to 0.50; absolute rates: 11% versus 31%), respectively. Drain usage, length of hospital stay, and time to resumption of normal day-to-day activities after surgery were statistically significantly lower in the sentinel lymph node biopsy group (all P < .001), and axillary operative time was reduced (P = .055). Overall patient-recorded quality of life and arm functioning scores were statistically significantly better in the sentinel lymph node biopsy group throughout (all P < or = .003). These benefits were seen with no increase in anxiety levels in the sentinel lymph node biopsy group (P > .05). CONCLUSION Sentinel lymph node biopsy is associated with reduced arm morbidity and better quality of life than standard axillary treatment and should be the treatment of choice for patients who have early-stage breast cancer with clinically negative nodes.