Miracle-dz/UniFAR-FTUs huggingface dataset:
Spatializing a Digital Text Archive about History

1 Introduction The amount of digital text data available in online libraries has risen dramatically in recent years. GoogleBooks or the Universal Digital Library (UDL) initiatives illustrate this impressively. The rapid evolution of vast digital text data archives has spurred the growth of an interdisciplinary Digital Humanities (DH) community, as [1] puts it, the once inaccessible has suddenly become accessible. Researchers in the humanities and social sciences have recognized the big potential digital text archives might offer to gain new insights on long-standing research questions. Especially interesting are unstructured or semi-structured digital libraries in this context, as text documents have been central to the humanities and social sciences long before digiti-zation. Along these developments, the need for automatically extracting new knowledge from text corpora using advanced data mining methods and information reduction techniques has risen as well. Text corpora also bear exciting research avenues for spatially aware disciplines and research fields, including geography, GIScience, and the interdisciplinary geographic information retrieval (GIR) community. This is because text documents often contain explicit and implicit spatio-temporal and thematic information, which can be automatically extracted, reorganized , visualized and analyzed for knowledge generation. We would like to introduce our interdisciplinary research project for discussion at the workshop which offers one avenue for bridging the gap between the digital humanities and GIScience. We combine methods from geographic information retrieval (GIR) and geovisual analytics (geoVA) in order to gain new insights from a digital dictionary about the history of Switzerland [2]. In own prior work, we illustrated how spatio-temporal analysis methods can be applied to a history text archive and how long-standing geographic principles (e.g., Tobler's law) might be verified with data not typically employed in GIScience [3,4]. For the workshop, we present preliminary findings of this spatio-temporal approach, and raise future work ideas for discussion. We are particularly interested in incorporating sentiment analyses in our work, in order to assess how (historical) places are referred to in texts over time. In our transdisciplinary approach we aim to create a geographic information observatory. We illustrate this by combining well established methods in GIScience to mine a typical data source for social science and humanities researchers, and by incorporating methods typically employed in social science (e.g., sentiment analysis) to expand the methodological toolkit in interdisciplinary GIScience research dealing with multivari
Educational Effectiveness, Target, and Content for Prudent Antibiotic Use

Widespread antimicrobial use and concomitant resistance have led to a significant threat to public health. Because inappropriate use and overuse of antibiotics based on insufficient knowledge are one of the major drivers of antibiotic resistance, education about prudent antibiotic use aimed at both the prescribers and the public is important. This review investigates recent studies on the effect of interventions for promoting prudent antibiotics prescribing. Up to now, most educational efforts have been targeted to medical professionals, and many studies showed that these educational efforts are significantly effective in reducing antibiotic prescribing. Recently, the development of educational programs to reduce antibiotic use is expanding into other groups, such as the adult public and children. The investigation of the contents of educational programs for prescribers and the public demonstrates that it is important to develop effective educational programs suitable for each group. In particular, it seems now to be crucial to develop appropriate curricula for teaching medical and nonmedical (pharmacy, dentistry, nursing, veterinary medicine, and midwifery) undergraduate students about general medicine, microbial virulence, mechanism of antibiotic resistance, and judicious antibiotic prescribing.
Reduced sigma point filters for the propagation of means and covariances through nonlinear transformations

The Unscented Transform (UT) approximates the result of applying a specified nonlinear transformation to a given mean and covariance estimate. The UT works by constructing a set of points, referred to as sigma points, which has the same known statistics, e.g., first and second and possibly higher moments, as the given estimate. The given nonlinear transformation Is applied to the set, and the unscented estimate is obtained by computing the statistics of the transformed set of sigma points. For example, the mean and covariance of the transformed set approximates the nonlinear transformation of the original mean and covariance estimate. The computational efficiency of the UT therefore depends on the number of sigma points required to capture the known statistics of the original estimate. In this paper we examine methods for minimizing the number of sigma points for real-time control, estimation, and filtering applications. We demonstrate results in a 3D localization example.
GEOLOGY, AGES AND TOPOGRAPHY OF SATURN'S SATELLITE DIONE OBSERVED BY THE CASSINI ISS CAMERA

Introduction: More than two decades ago, the cameras aboard the two Voyager spacecraft imaged Saturn's satellite Dione (1124 km in diameter) at spatial resolutions of at least 1 km/pxl. Its surface is characterized by (1) cratered plains with varying crater frequencies and ages, (2) smooth plains which were believed to be volcanic extrusions of an H 2 O-NH 3 eutectic melt, and (3) tectonic features such as scarps, troughs and ridges [1][2][3]. These features which are indicative of extension as well as compression could have been a consequence of several periods of global expansion and contraction through time [3][4]. The trailing hemisphere, imaged only at low resolution (> 5 km/pxl) by Voyager, shows a system of very bright, filament-like linear markings termed wispy material [2]. It was interpreted as a surficial deposit associated with volcanic exhalations along cracks [1][2]. Image data base: Since the Cassini Orbiter has been inserted into an excentric orbit around Saturn on July 1, 2004, image data at resolutions up to 15 m/pxl were obtained by the Cassini ISS cameras (Narrow (NAC) and Wide Angle Camera (WAC)) in two non-targeted flybys (Dec. 2004, June 2005), and a targeted flyby in Oct. 2005. The areas not very well covered by Voyager were imaged in these encounters showing more or less unknown terrain in much better detail (e.g. Fig. 1). Procedure: The topics addressed in this paper are: (1) What are the geologic units seen in the areas imaged by Cassini ISS, what is their stratigraphic sequence, and how do they compare to the units mapped on Voyager data ? (2) What are the ages of these units, obtained from crater size-frequency measurements and from application of impact chronology models ? Is there a Crater Population I & II as has been suggested by [1] ? (3) Is there evidence for past cryovolcanic activity ? (4) What is the nature of the wispy terrain seen on the trailing hemisphere ? Ages are assigned by means of impact cratering chronology models. Two such models are currently used: (a) Model I with a lunar-like (exponential) decay in cratering rate with time (Late Heavy Bombardment (LHB)), and with a more or less constant cratering rate since about 3 b.y. (billion years) [5][6][7], and (b) Model II with a constant cratering rate throughout most of solar system history [8].
A multicast QoS Control scheme and system in EPON system

This paper is about a multicast QoS Control scheme in EPON system. To provide QoS assurance for multicast traffic in EPON system, especially for video service, multicast group address based QoS control and IP layer to physical layer QoS transfer control are implemented in EPON system. The multicast group address based QoS control means the system can assure QoS on base of multicast group address info. The IP layer to physical layer QoS transfer control means the system can set physical QoS directly by using IP layer info. Three ways for this technique are explained. And an experiment system is introduced then. Finally this paper concludes that this technique provides QoS assurance for multicast traffic in EPON system.
Meliorated approach for extracting bilingual terminology from Wikipedia

With the demand of accurate and domain specific bilingual dictionaries, research in the field of automatic dictionary extraction has become popular. Due to lack of domain specific terminology in parallel corpora, extraction of bilingual terminology from Wikipedia (a corpus for knowledge extraction having a huge amount of articles, links within different languages, a dense link structure and a number of redirect pages) has taken up a new research in the field of bilingual dictionary creation. Our method not only analyzes interlanguage links along with redirect page titles and link text titles but also filters out inaccurate translation candidates using pattern matching. Score of each translation candidate is calculated using page parameters and then setting an appropriate threshold as compared to previous approach, which was solely, based on backward links. In our experiment, we proved the advantages of our approach compared to the traditional approach.
Rapid Exocytosis in Single Chromaffin Cells Recorded from Mouse Adrenal Slices

We report here that brief depolarizations such as action potentials trigger exocytosis in thin mouse adrenal slices. The secretory rates obtained in membrane capacitance recordings from chromaffin cells in slices are faster than those observed in isolated cells. Fast exocytosis in slices is attributable to the rapid release of a small pool of vesicles. The pool recovers from depletion with a time constant of 10 sec. Recruitment of the rapidly released vesicles is strongly hindered by the fast Ca2+ chelator BAPTA and much less by the slower chelator EGTA. We suggest that these vesicles are located in close proximity to Ca2+ channels. Spatial coupling of Ca2+ entry and exocytosis may be sensitive to cell isolation and culture.
Relationship between visual-motor integration and handwriting skills of children in kindergarten: a modified replication study.

OBJECTIVE The purpose of this study was to examine the relationship of performance on the Developmental Test of Visual-Motor Integration (VMI; Beery, 1997) to handwriting legibility in children attending kindergarten. The relationship of using lined versus unlined paper on letter legibility, based on a modified version of the Scale of Children's Readiness in PrinTing (Modified SCRIPT; Weil & Cunningham Amundson, 1994) was also investigated. METHOD Fifty-four typically developing kindergarten students were administered the VMI; 30 students completed the Modified SCRIPT with unlined paper, 24 students completed the Modified SCRIPT with lined paper. Students were assessed in the first quarter of the kindergarten school year and scores were analyzed using correlational and nonparametric statistical measures. RESULTS Strong positive relationships were found between VMI assessment scores and student's ability to legibly copy letterforms. Students who could copy the first nine forms on the VMI performed significantly better than students who could not correctly copy the first nine VMI forms on both versions of the Modified SCRIPT. CONCLUSION Visual-motor integration skills were shown to be related to the ability to copy letters legibly. These findings support the research of Weil and Cunningham Amundson. Findings from this study also support the conclusion that there is no significant difference in letter writing legibility between students who use paper with or without lines.
HIV-1 Inhibits Autophagy in Bystander Macrophage/Monocytic Cells through Src-Akt and STAT3

Autophagy is a homeostatic mechanism of lysosomal degradation. Defective autophagy has been linked to various disorders such as impaired control of pathogens and neurodegeneration. Autophagy is regulated by a complex array of signaling pathways that act upstream of autophagy proteins. Little is known about the role of altered regulatory signaling in disorders associated with defective autophagy. In particular, it is not known if pathogens inhibit autophagy by modulation of upstream regulatory pathways. Cells infected with HIV-1 blocked rapamycin-induced autophagy and CD40-induced autophagic killing of Toxoplasma gondii in bystander (non-HIV-1 infected) macrophage/monocytic cells. Blockade of autophagy was dependent on Src-Akt and STAT3 triggered by HIV-1 Tat and IL-10. Neutralization of the upstream receptors VEGFR, β-integrin or CXCR4, as well as of HIV-1 Tat or IL-10 restored autophagy in macrophage/monocytic cells exposed to HIV-1-infected cells. Defective autophagic killing of T. gondii was detected in monocyte-derived macrophages from a subset of HIV-1+ patients. This defect was also reverted by neutralization of Tat or IL-10. These studies revealed that a pathogen can impair autophagy in non-infected cells by activating counter-regulatory pathways. The fact that pharmacologic manipulation of cell signaling restored autophagy in cells exposed to HIV-1-infected cells raises the possibility of therapeutic manipulation of cell signaling to restore autophagy in HIV-1 infection.
The impact of new diagnostic methodologies in the management of meningitis in adults at a teaching hospital.

BACKGROUND Suspected meningitis is a frequent reason for admission to hospital in the UK. While bacterial meningitis requires prompt antibiotic therapy to reduce mortality and morbidity, enteroviral meningitis, the most frequent viral cause, is almost invariably a benign disease. AIM To determine the clinical presentation, laboratory findings and outcome of meningitis by microbiological aetiology and patient age, and to assess the clinical management of adults presenting with meningitis, with reference to national guidelines. DESIGN Retrospective case-note review. METHODS Adult (>14 years) admissions to Addenbrooke's Hospital with meningitis or meningococcal septicaemia March 1996-September 2001 were audited retrospectively. The case definition was: symptoms compatible with meningitis, and either abnormal CSF (leukocytes >5x10(9)/ml) or meningococcal disease. The only exclusion criterion was the presence of a ventricular shunt. RESULTS Only 30% of patients seen by a General Practitioner were given pre-admission antibiotics. In a substantial number of cases, including those with bacterial meningitis, antibiotic administration was delayed either because patients were sent for CT head scans (delaying a lumbar puncture) or because the diagnosis was not considered, especially in elderly patients with reduced conscious levels. There were no confirmed cases of H. influenzae meningitis. Overall outcomes in terms of mortality and disability were similar to UK national data. A surprising number of patients (40%) were afebrile on admission. DISCUSSION The proportion of patients with meningitis given pre-hospital antibiotics by GPs is still worryingly low, although early hospital management has improved. Improved diagnostic facilities, particularly viral PCR assays, reduce antibiotic usage and hospital stay, with considerable financial savings.
Charged Higgs bosons in minimal supersymmetry: updated constraints and experimental prospects

We discuss the phenomenology of charged Higgs bosons in the MSSM with minimal flavor violation. In addition to the constrained MSSM (CMSSM) with universal soft supersymmetry breaking mass parameters at the GUT scale, we explore non-universal Higgs mass models (NUHM) where this universality condition is relaxed. To identify the allowed parameter space regions, we apply constraints from direct searches, low energy observables, and cosmology. We find that values of the charged Higgs mass as low as mH+ 135 GeV can be accommodated in the NUHM models, but that several flavor physics observables disfavor large H+ contributions, associated with high tan β, quite independently of MSSM scenario. We confront the constrained scenarios with the discovery potentials reported by ATLAS and CMS, and find that the current exclusion by indirect constraints is similar to the expected LHC discovery reach with 30 fb−1 of data. Finally, we evaluate the sensitivity of the presented discovery potential to the choice of MSSM benchmark scenario. This sensitivity is found to be higher in the case of a light (mH+ < mt) charged Higgs.
Diabetes-Induced Vascular Hypertrophy Is Accompanied by Activation of Na+-H+ Exchange and Prevented by Na+-H+ Exchange Inhibition

Abstract— Vascular disease often involves vessel hypertrophy with underlying cellular hypertrophy or hyperplasia. Experimental diabetes stimulates hypertrophy of the rat mesenteric vasculature, and we investigated the hypothesis that this hypertrophy is associated with activation of Na+-H+ exchange (NHE) activity. We measured the NHE activity in isolated, intact blood vessels from control and streptozotocin-induced diabetic adult rats using concurrent myography and fluorescence spectroscopy. The role of inhibiting NHE activity in preventing the development of the mesenteric hypertrophy in streptozotocin-diabetic rats was investigated by administration of cariporide (100 mg/kg body weight per day in 3 doses by gavage) after induction of diabetes and subsequently determining vessel weight and structure. The weight of the mesenteric vasculature was not increased 1 week after streptozotocin treatment but was significantly increased by an average of 56% at 3 weeks. NHE activity in mesenteric arteries showed an enhanced maximal velocity (Vmax) in diabetic vessels at 1 and 3 weeks (0.246±0.006 and 0.238±0.007 versus 0.198±0.007 pH U/min) with no change in the apparent Km. Moreover, NHE-1 mRNA in mesenteric arterioles at 3 weeks after streptozotocin treatment was increased by >60% (55.8±6.4 versus 91.3±12.3 fg). Administration of cariporide significantly reduced mesenteric vascular weight, the wall/lumen ratio, and mesenteric extracellular matrix accumulation in the diabetic animals. Our study shows that diabetes in vivo correlates with elevated NHE activity and mRNA in the mesenteric vasculature and furthermore that inhibition of this system prevents the hypertrophic response. These data suggest that NHE may be a target for therapeutic modulation of vascular changes in diabetes.
Data quality: A survey of data quality dimensions

Nowadays, activities and decisions making in an organization is based on data and information obtained from data analysis, which provides various services for constructing reliable and accurate process. As data are significant resources in all organizations the quality of data is critical for managers and operating processes to identify related performance issues. Moreover, high quality data can increase opportunity for achieving top services in an organization. However, identifying various aspects of data quality from definition, dimensions, types, strategies, techniques are essential to equip methods and processes for improving data. This paper focuses on systematic review of data quality dimensions in order to use at proposed framework which combining data mining and statistical techniques to measure dependencies among dimensions and illustrate how extracting knowledge can increase process quality.
Effects of isokinetic strength training on concentric and eccentric torque development in the ankle dorsiflexors of older adults.

This study quantifies concentric and eccentric dorsiflexor muscle torque at various movement velocities and determines the neuromuscular effects from short-term practice of repeated maximal voluntary contractions using an isokinetic resisted exercise program in older adults. Twenty-eight subjects (76.3+/-4.6 years) trained concentric and eccentric dorsiflexion 3 days per week for 2 weeks at 30 degrees, 90 degrees, and 180 degrees/s through 40 degrees of dorsiflexion range of motion. Peak torque, rate of torque development, surface electromyography, and strength curves at each velocity were compared before and after training. Increases were found for concentric (27%) and eccentric (20%) dorsiflexor peak torque and concentric rate of torque production (20%-53%) across all movement velocities (p < .01). Training also significantly increased dorsiflexor concentric (64%) and eccentric (55%) surface electromyography; taken together, this is evidence of apparent adaptation of neural factors in older adults with short-term training. These findings support that eccentric and concentric strength training enhances the control and production of ankle muscle dorsiflexor torque in older adults, with implications for improving functional mobility of the ankle joint.
Development of a mobile e-Health care system for rapid detection of emergent situations

In recent years, one of the common issues is an e-Health care system which makes available health management and medical services at any time and in any place. This study describes the development of an e-Health care system that can promptly detect and cope with emergent situations happening to chronic disease patients in their everyday life. If a patient's emergent situation is detected by a personal mobile host composed of acceleration and vibration sensors, GPS, and a code division multiple access communication module, a text message on the patient's current location is transmitted to the hospital and the guardian's mobile terminal, so that they can cope with the situation immediately. Particularly through a back-propagation network, the system analyzes data from sensors and determines emergent situations, such as fainting and seizures, promptly. The automatic diagnostic performance is measured by precision and recall from the data of a back-propagation neural network. The number of experiments for a normal walking state, seizure, and fainting situation is 200 each, respectively. Out of these experiments, fainting can be best diagnosed, with 90% precision. In that case, recall is 97%. The experiments show that this system is very effective in finding emergencies promptly for chronic disease patients who cannot take care of themselves, and it is expected to save many lives. The exact location of patients can also be found on the electronic map by using GPS information.
A phonetic concatenative approach of labial coarticulation

Predicting the effects of labial coarticulation is an important aspect with a view to developing an artificial talking head. This paper describes a concatenation approach that uses sigmoids to represent the evolution of labial parameters. Labial parameters considered are lip aperture, protrusion, stretching and jaw aperture. A first formal algorithm determines the relevant transitions, i.e. those corresponding to phonemes imposing constraints on one of the labial parameters. Then relevant transitions are either retrieved or interpolated from a set of reference sigmoids which have been trained on a speaker specific corpus. This labial corpus is made up of isolated vowels, CV, VCV, VCCV and 100 sentences. A final stage consists in improving the overall syntagmatic consistency of the concatenation.