Miracle-dz/UniFAR-FTUs huggingface dataset:
Therapy for Stage IV Non–Small-Cell Lung Cancer Without Driver Alterations: ASCO Living Guideline

Living guidelines are routinely updated guidelines that are developed for selected topic areas with rapidly evolving evidence that drives frequent change in clinical practice. These guidelines are updated on a regular schedule, based on the work of a standing panel that reviews the literature on a continuous basis. Updates will be made regularly and can be found at https://ascopubs.org/nsclc-non-da-living-guideline. PURPOSE To provide evidence-based recommendations updating the 2020 ASCO and Ontario Health (Cancer Care Ontario) guideline on systemic therapy for patients with stage IV non–small-cell lung cancer without driver alterations. METHODS ASCO updated recommendations on the basis of an ongoing systematic review of randomized clinical trials from 2018 to 2021. RESULTS This guideline update reflects changes in evidence since the previous update. Five randomized clinical trials provide the evidence base. Outcomes of interest include efficacy and safety. RECOMMENDATIONS In addition to 2020 options for patients with high programmed death ligand-1 (PD-L1) expression (tumor proportion score [TPS] ≥ 50%), nonsquamous cell carcinoma (non-SCC), and performance status (PS) 0-1, clinicians may offer single-agent atezolizumab. With high PD-L1 expression (TPS ≥ 50%), non-SCC, and PS 0-1, clinicians may offer nivolumab and ipilumumab alone or nivolumab and ipilimumab plus chemotherapy. With negative (0%) and low positive PD-L1 expression (TPS 1%-49%), non-SCC, and PS 0-1, clinicians may offer nivolumab and ipilimumab alone or nivolumab and ipilimumab plus chemotherapy. With high PD-L1 expression, SCC, and PS 0-1, clinicians may offer single-agent atezolizumab. With high PD-L1 expression, squamous cell carcinoma (SCC), and PS 0-1, clinicians may offer nivolumab and ipilimumab alone or in combination with two cycles of platinum-based chemotherapy. With negative and low positive PD-L1 expression, SCC, and PS 0-1, clinicians may offer nivolumab and ipilimumab alone or in combination with two cycles of platinum-based chemotherapy. With non-SCC who received an immune checkpoint inhibitor and chemotherapy as first-line therapy, clinicians may offer second-line paclitaxel plus bevacizumab. With non-SCC, who received chemotherapy with or without bevacizumab and immune checkpoint inhibitor therapy, clinicians should offer the options of third-line single-agent pemetrexed, docetaxel, or paclitaxel plus bevacizumab. Additional information is available at www.asco. org/thoracic-cancer-guidelines.
Hexahedral-dominant meshing

This article introduces a method that generates a hexahedral-dominant mesh from an input tetrahedral mesh. It follows a three-step pipeline similar to the one proposed by Carrier Baudoin et al.: (1) generate a frame field, (2) generate a pointset P that is mostly organized on a regular grid locally aligned with the frame field, and (3) generate the hexahedral-dominant mesh by recombining the tetrahedra obtained from the constrained Delaunay triangulation of P. For step (1), we use a state-of-the-art algorithm to generate a smooth frame field. For step (2), we introduce an extension of Periodic Global Parameterization to the volumetric case. As compared with other global parameterization methods (such as CubeCover), our method relaxes some global constraints to avoid creating degenerate elements, at the expense of introducing some singularities that are meshed using non-hexahedral elements. For step (3), we build on the formalism introduced by Meshkat and Talmor, fill in a gap in their proof, and provide a complete enumeration of all the possible recombinations, as well as an algorithm that efficiently detects all the matches in a tetrahedral mesh. The method is evaluated and compared with the state of the art on a database of examples with various mesh complexities, varying from academic examples to real industrial cases. Compared with the method of Carrier-Baudoin et al., the method results in better scores for classical quality criteria of hexahedral-dominant meshes (hexahedral proportion, scaled Jacobian, etc.). The method also shows better robustness than CubeCover and its derivatives when applied to complicated industrial models.
The influence of marine-derived nutrient subsidies on streams and lakes at Izembek National Wildlife Refuge

By Sarah G. Winikoff Although the effects of Pacific salmon spawners have been well-studied in the Pacific Northwest, their influence remains relatively unexplored across portions of their range including the North Pacific Rim and along the Alaska Peninsula. In my first data chapter, I examined whether the influence of salmon on streams and lakes at Izembek National Wildlife Refuge (INWR) was similar to previously studied salmon-bearing ecosystems. At INWR, the impact of salmon was smaller than elsewhere, likely due to small run sizes and regional environmental characteristics including very low background molar nitrogen to phosphorous ratios. Nevertheless, I found that upstream and downstream reaches within a single watershed can respond differently to salmon migration, suggesting that salmon differentially influence freshwater ecosystems depending on landscape position. In my second data chapter, I examined whether marinederived nutrient subsidies from salmon and waterbirds differ in their effects on lake ecosystems. In general, lakes receiving subsidies had higher nutrient concentrations than lakes with no significant subsidies, and water column chl-a was positively correlated to
ACR–ASTRO PRACTICE PARAMETER FOR THE PERFORMANCE OF STEREOTACTIC BODY RADIATION THERAPY

This document is an educational tool designed to assist practitioners in providing appropriate radiologic care for patients. Practice Parameters and Technical Standards are not inflexible rules or requirements of practice and are not intended, nor should they be used, to establish a legal standard of care1. For these reasons and those set forth below, the American College of Radiology and our collaborating medical specialty societies caution against the use of these documents in litigation in which the clinical decisions of a practitioner are called into question.
Optimising the Unexpected : Computational Design Approach in Expressive Gestural Interaction

Paste the appropriate copyright statement here. ACM now supports three different copyright statements: • ACM copyright: ACM holds the copyright on the work. This is the historical approach. • License: The author(s) retain copyright, but ACM receives an exclusive publication license. • Open Access: The author(s) wish to pay for the work to be open access. The additional fee must be paid to ACM. This text field is large enough to hold the appropriate release statement assuming it is single spaced. Every submission will be assigned their own unique DOI string to be included here. Abstract In our work on computational design of expressive gestural interaction, we experienced various challenges for advanced optimisation methods. Here we want to highlight two of these challenges based on the design and the use of a Bayesian model called Gesture Variation Follower, with the aim to discuss such challenges with a broader community of designers and HCI practitioners during the workshop.
Comovement and contagion in commodity markets

Abstract This article investigates comovement and contagions in the commodities markets. We examine the comovement by analyzing the unconditional correlation coefficients. We document that commodities tend to partially integrate. We perform contagion tests by identifying coexceedances and estimating multinomial logit to explain the joint occurrence of those coexceedances. We document that commodities price changes tend to affect the probability of both positive and negative coexceedances. Overall, we conclude that there are comovement and contagions among commodities. However, the degrees of comovement and contagion are different among commodities and between positive and negative extreme returns. The contagion among commodities is asymmetric.
Geophysical data from U.S. Arctic Ocean drift stations 1957-1960 : Research Note

Abstract : Geophysical data taken from March 1957 to September 1960 at the three United States Arctic Ocean drifting stations, ALPHA, T-3 (BRAVO), and CHARLIE, are presented. The tabulations include station positions, ocean depths, oceanographic data, observed gravity and anomalies, and values of some of the magnetic elements. Field procedures are described. A bibliography of reports derived from the scientific programs during this period is included.
Submitted : Textbook of Neural Repair and Rehabilitation (

One overarching goal drives our research and development activities: to revolutionize rehabilitation medicine with robotics, mechatronics, and information technologies that can assist movement, enhance treatment and quantify outcomes. In this chapter, we present three fronts of this revolution: rehabilitation robotics, orthotics, and prosthetics. The first and newest approach, rehabilitation robotics, has grown significantly in the last ten years (c.f. Previously, robotics were incorporated into assistive devices to help the physically challenged accommodate their impairment. Rehabilitation robotics, by contrast, fashions a new class of
Menstrual Blood-Derived Stem Cell Paracrine Factors Possess Stimulatory Effects on Chondrogenesis In Vitro and Diminish the Degradation of Articular Cartilage during Osteoarthritis

Articular cartilage is an avascular tissue with a limited capacity for self-regeneration, leading the tissue to osteoarthritis (OA). Mesenchymal stem cells (MSCs) are promising for cartilage tissue engineering, as they are capable of differentiating into chondrocyte-like cells and secreting a number of active molecules that are important for cartilage extracellular matrix (ECM) synthesis. The aim of this study was to evaluate the potential of easily accessible menstrual blood-derived MSC (MenSC) paracrine factors in stimulating bone marrow MSC (BMMSCs) chondrogenic differentiation and to investigate their role in protecting cartilage from degradation in vitro. MenSCs and BMMSCs chondrogenic differentiation was induced using four different growth factors: TGF-β3, activin A, BMP-2, and IGF-1. The chondrogenic differentiation of BMMSCs was stimulated in co-cultures with MenSCs and cartilage explants co-cultured with MenSCs for 21 days. The chondrogenic capacity of BMMSCs was analyzed by the secretion of four growth factors and cartilage oligomeric matrix protein, as well as the release and synthesis of cartilage ECM proteins, and chondrogenic gene expression in cartilage explants. Our results suggest that MenSCs stimulate chondrogenic response in BMMSCs by secreting activin A and TGF-β3 and may have protective effects on cartilage tissue ECM by decreasing the release of GAGs, most likely through the modulation of activin A related molecular pathway. In conclusion, paracrine factors secreted by MenSCs may turn out to be a promising therapeutical approach for cartilage tissue protection and repair.
Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-β deposition

Abstract Alzheimer’s disease (AD) is characterised by the aggregation and deposition of amyloid-β (Aβ) peptides in the human brain. In age-related late-onset AD, deficient degradation and clearance, rather than enhanced production, of Aβ contributes to disease pathology. In the present study, we assessed the contribution of the two key Aβ-degrading zinc metalloproteases, insulin-degrading enzyme (IDE) and neprilysin (NEP), to Aβ degradation in human induced pluripotent stem cell (iPSC)-derived cortical neurons. Using an Aβ fluorescence polarisation assay, inhibition of IDE but not of NEP, blocked the degradation of Aβ by human neurons. When the neurons were grown in a 3D extracellular matrix to visualise Aβ deposition, inhibition of IDE but not NEP, increased the number of Aβ deposits. The resulting Aβ deposits were stained with the conformation-dependent, anti-amyloid antibodies A11 and OC that recognise Aβ aggregates in the human AD brain. Inhibition of the Aβ-forming β-secretase prevented the formation of the IDE-inhibited Aβ deposits. These data indicate that inhibition of IDE in live human neurons grown in a 3D matrix increased the deposition of Aβ derived from the proteolytic cleavage of the amyloid precursor protein. This work has implications for strategies aimed at enhancing IDE activity to promote Aβ degradation in AD.
Estimativa de parâmetros hidrodinâmicos de aquíferos em áreas de embasamento através de métodos indiretos.

The recession represents the period when the river’s flow is maintained predominately by subterranean water return, so establishing the base flux. In hydrographic basins, the recession coefficient (or of drain) can be determined in an indirect manner by several graph methods using series of hydrologic data. From this coefficient is possible to calculate other important parameters, like the aquifer transmissivity. The recession coefficient still turns possible to get information about the minimal flow in the drainage channels, that usually are obtained toward other hydrological indexes, as the Q7,10, frequently used in management of superficial hydrological resource. In this work were determined the recession coefficient, the transmissivity and the store coefficient for six basins, towards several indirect methods. There were also calculated some morfometrics indexes, how the amplitude, the slope index and the compactness index, allowing thus the correlation between the morfometrics characteristics of the basins and their hemodynamic parameters. The methods used to determine the recession coefficient were: Maillet, Boussinesq, Correlation, Matching Strip e Drogue. To obtain the transmissivity, beyond the use of recession coefficient of Maillet’s and Boussinesq’s methods, the Brutsaert method was used too; however, this last method presented results much higher than the traditionally described in the literature. The basins studied occur in regions where the predominance is of granite-gnaissic rocks, and under similar vegetation, climatic, use and occupancy, located in the Central-South region of Minas Gerais state. One of those is the Maracuja river basin, inserted in the Metamorfico Bacao complex, on Quadrilatero Ferrifero (QF). The other basins are located at west of QF, on the Metamorfico Campo Belo complex. Regarding the used methods, was verified that, the Boussinesq method presented the best relation between their recession and transmissivity coefficients when confronted with others indexes of the basins, as area, Q7,10, compactness index and slope index. From the analysis of the results and the previous results were ascertained that the biggest basins with most plan relief have bigger capacity to store water, liberating it slowly, so contributing for the sustainable maintenance of the base flux. In head basins this behavior is reverse. The estimate of renewable reserves from the recession coefficient provides results that can be used how a tool of determination of subterranean water quantity to be explored on the basins. The results revealed that the recession coefficient constitute an efficient parameter of interest for the subterranean water explore and to manage the hydrographic basins.
Estimation of surface-based duct parameters from automatic identification system using the Levy flight quantum-behaved particle swarm optimization algorithm

Abstract Atmospheric duct propagation has a significant influence on the performance of wireless communication and radar systems in the maritime environment that makes it essential to master the detailed knowledge of the atmospheric refractivity profile. Automatic identification system (AIS) is a maritime navigation safety communication system that operates in the very high frequency mobile band and the propagation path of AIS signals will be influenced by different atmospheric conditions. In this paper, a new refractivity estimation method based on the AIS signal level is proposed and the Levy flight quantum-behaved particle swarm optimization (LFQPSO) algorithm is presented and applied in the new estimation method to estimate the surface based duct parameters. Numerical simulations demonstrate that the LFQPSO algorithmhas good robustness and the new refractivity estimation method based on the AIS signal level can provide near-real-time estimation ofatmospheric refractivity.
Determination of the tension limit forces of a barley malt and a malt crush in correlation with a load size

This article deals with determination of selected parameters of barley malt (whole grain and crushed grain). The barley malt is besides water, hops and brewer's yeast, one of the basic ingredients necessary for the production of traditional Czech pilsner type of beer. The aim of this research is to determine limit force and internal friction angle with depending on the size of the load. The assessed malt crush was produced using a 2-roller malt mill. The 2-roller malt mill is based on the principle of grinding the material in a milling gap between two milling rollers, which is a very commonly used production of the malt crush. By determining the tension limits of the barley malt and the malt crush in correlation with the load, we can obtain very important parameters that inform us of the bulk material behavior, particularly with respect to the storage method (storage shape, height of the stored material layer, and the removal method from the storage, etc.), and to the transport (route gradient, transport speed, etc.). The determination of the tension limits has a direct link with cohesion of the bulk material and thereby contributes to establishing of the basic parameters of the bulk material, such as the friction angle. The measurement for the angle of internal friction determination were performed on a prototype device. The principle of measurement on a mobile prototype devices is, the upper square chamber slides down the lower square chamber. Barley malt (whole grain and crushed grain) were loaded from 100 g to 5,000 g. The results of measuring were statistically analyzed with software Statistica 12.
Extracellular Vesicle MicroRNAs in Heart Failure: Pathophysiological Mediators and Therapeutic Targets

Extracellular vesicles (EVs) are emerging mediators of intracellular and inter-organ communications in cardiovascular diseases (CVDs), especially in the pathogenesis of heart failure through the transference of EV-containing bioactive substances. microRNAs (miRNAs) are contained in EV cargo and are involved in the progression of heart failure. Over the past several years, a growing body of evidence has suggested that the biogenesis of miRNAs and EVs is tightly regulated, and the sorting of miRNAs into EVs is highly selective and tightly controlled. Extracellular miRNAs, particularly circulating EV-miRNAs, have shown promising potential as prognostic and diagnostic biomarkers for heart failure and as therapeutic targets. In this review, we summarize the latest progress concerning the role of EV-miRNAs in HF and their application in a therapeutic strategy development for heart failure.
The Effect of Health Education on Migration Health: Evidence from a Large Migrant Survey in China

Reducing health inequities for migrants is a huge challenge shared globally. Based on big data of China Migrants Dynamic Survey in 2017, this paper applied Ordered Logit models and Logit models to examine the effect of health education on the health of migrants. Propensity score matching and instrumental variable were also employed to solve the endogenous problem. This paper found a significant health promotion effect of health education on the health of migrants, which remained significant after a series of robustness check. Further analysis showed that consultative health education is more effective than nonconsultative health education. Meanwhile, the positive association between health education and migrants' health behavior was identified which provided empirical evidence for knowledge, attitude, and practices theory. Heterogeneity analyses supported that health education has a stronger effect on migrants who were female, elderly, highly educated, and did not have chronic diseases than on those who were male, younger, less educated, and had chronic diseases. This paper demonstrates that health education is an important health promotion factor for migrants empirically and that the government should take actions to provide sufficient and targeted health education for migrants to promote their health.
Banking Competition, Efficiency and Stability in the MENA Region

The intensification of competition in the banking market following the adoption of financial liberalisation and deregulation policies all over the world has raised questions about their impact on the stability of the banking sectors. This study aims at participating in the continuous debate on how the competition conditions in the market affects the stability of banks in the MENA region. This study exploits a sample of 216 MENA banks operating over the period 1999-2019, and adopts the GMM method to detect the association between banking competition and stability. The empirical results show that market power has a negative effect on banking stability. This result has implications suggesting that the adverse effect of concentration on banking stability implies that regulators should be careful in pushing/encouraging banks consolidate, as this may reduce stability.
Accuracy of wave runup formula on contrasting Southeast Australian beaches

This paper presents runup data collected on three contrasting beaches in southeastern Australia. Runup data in this study were collected using optical remote sensing methods. Data were collected at three beaches on the New South Wales and southeast Queensland coastlines. All data are referenced to the Australian Height Datum, which provides a vital reference for local hazard analysis. Data have been analysed to find exceedence statistics for each beach: both the 2% runup exceedence and the maximum runup. These observed values are compared to modelled values from a range of widely used empirical models to assess which model is the most accurate for each beach.
Exposure to Cadmium Telluride Quantum Dots and Gene Expression Profile of Huh-7 Hepatocellular Carcinoma Cell Line

Nanoparticles have shown promising potential for efficient drug delivery, circumventing biological interferences like immunological and renal clearance and mechanical and enzymatic destruction. However, a handful of research papers have questioned the biomedical use of metal-based nanoparticles like cadmium telluride quantum dots (CdTe-QDs) for their cytotoxic, genotoxic, and carcinogenic potential. Herein, we examined the effects of CdTe-QD NPs on gene expression profile of hepatocellular carcinoma (Huh-7) cell line. Huh-7 cells were treated with CdTe-QD NPs (10 μg/ml for 6, 12, and 24 hours, and 25 μg/ml for 6 and 12 hours), and transcriptomic analysis was performed using microarray to evaluate the global gene expression profile. Differential expressed genes (DEGs) were observed for both the doses (10 and 25 μg/ml) of CdTe-QD NPs at different time points. Gene ontology (GO) analysis revealed that genes involved in molecular function of cell cycle, organizational injury and abnormalities, cell death and survival, gene expression, cancer, organismal survival, and cellular development were differentially expressed. Overall, we have demonstrated differential expression of several genes, involved in maintaining cell survival, metabolism, and genome integrity. These findings were confirmed by RT-qPCR study for some canonical pathway genes signifying possible implication in NP toxicity-mediated cell survival and inhibition of cell death.