Miracle-dz/UniFAR-FTUs huggingface dataset:
CD4 T‐Cell‐mediated immune response to prostatic proteins in HLA‐DRB1*1503 transgenic mice and identification of a novel HLA‐DRB1*1503‐restricted T‐cell epitope from human prostatic acid phosphatase

Transgenic mice engineered to express human leukocyte antigen (HLA) alleles are widely used for identification of immunogenic and naturally processed epitopes. Using HLA‐DRB1*1501 (DR2b) transgenic mice, we have previously identified epitopes from two prostatic antigens, prostate‐specific antigen (PSA) and prostatic acid phosphatase (PAP). These antigens are implicated in the development of autoimmunity in the prostate and also are considered promising targets for prostate cancer immunotherapy. HLA‐DRB1*1501 is the most common DR15 allele in Caucasians, while HLA‐DRB1*1503 is the most common in African Americans. Hence characterization of peptide immunogenicity for these alleles is important for the development of prostate cancer immunotherapy in white and black patients.
Ambulatory blood pressure and the metabolic syndrome in normotensive and untreated hypertensive men.

BACKGROUND Components of the metabolic syndrome are typically intercorrelated in epidemiologic studies and, when combined, predict type 2 diabetes and cardiovascular diseases. However, it remains unclear whether a single construct underlies the various components and which of the components are most closely associated with the underlying syndrome. Here, we use our confirmatory factor analytic model of the metabolic syndrome to examine the extent to which measures of ambulatory blood pressure, reflecting blood pressure variability throughout the day and night, may strengthen the association between blood pressure and the other components of the syndrome. METHODS Participants were a community sample of 358 men (248 with hypertension), ages 40-70, not receiving antihypertensive medications. Confirmatory factor analysis was employed to examine model fit and the strength of association between clinic and ambulatory blood pressure and the metabolic syndrome. RESULTS The blood pressure factor loaded significantly on the underlying metabolic syndrome but the strength of association was not as great (loading = 0.34, p < 0.01) as those observed for the obesity, insulin resistance and lipid factors. The factor loadings for the ambulatory measures (awake loading = 0.19; sleep loading = 0.16, p values < 0.01) were significant but smaller in magnitude than the loadings for clinic blood pressure. CONCLUSIONS Both clinic and ambulatory measures of blood pressure are significantly associated with the underlying metabolic syndrome using confirmatory factor analytic methods. However, the strength of association appears greater for the clinic measures relative to the ambulatory measures in this study.
Kalman filtering parameter optimization techniques based on genetic algorithm

Kalman filter is widely used to restrain noise existing in flight control system of UAV due to its many merits. However, the effect is very sensitive to Kalman filter parameters, whose choice depends on operatorpsilas experience extremely. A GA-based filter parameters optimization approach is presented. In this approach, GA is employed to find out the optimal Kalman filter parameters by way of minimizing objective function which includes such terms as variance of model uncertainty, variance of measurement noise, covariance of estimate error in initial states. The simulation results show that the approach can improve accuracy and stability of Kalman filter.
Development of a Policy-Relevant Child Maltreatment Research Strategy

Child maltreatment is associated with a huge burden of suffering, yet there are serious gaps in knowledge about its epidemiology and approaches to intervention. This article describes the development of a proposed national research framework in child maltreatment, as requested by the Department of Justice, Canada, based on (1) a review of the literature, (2) consultation with experts, and (3) application of evaluation criteria for considering research priorities. The article identifies gaps in knowledge about child maltreatment in Canada and proposes a research agenda to make evidence-based policy decisions more likely. Although this work was driven by gaps in Canada's knowledge about child maltreatment, the international scope of the review and consultation process could make the findings useful to broader research and policy audiences.
Properties and regulation of gap junctional hemichannels in the plasma membranes of cultured cells

During the assembly of gap junctions, a hemichannel in the plasma membrane of one cell is thought to align and dock with another in an apposed membrane to form a cell-to-cell channel. We report here on the existence and properties of nonjunctional, plasma membrane connexin43 (Cx43) hemichannels. The opening of the hemichannels was demonstrated by the cellular uptake of 5(6)-carboxyfluorescein from the culture medium when extracellular calcium levels were reduced. Dye uptake exhibited properties similar to those of gap junction channels. For example, using different dyes, the levels of uptake were correlated with molecular size: 5(6)-carboxyfluorescein (approximately 32%), 7- hydroxycoumarin-3-carboxylic acid (approximately 24%), fura-2 (approximately 11%), and fluorescein-dextran (approximately 0.4%). Octanol and heptanol also reduced dye uptake by approximately 50%. Detailed analysis of one clone of Novikoff cells transfected with a Cx43 antisense expression vector revealed a reduction in dye uptake levels according to uptake assays and a corresponding decrease in intercellular dye transfer rates in microinjection experiments. In addition, a more limited decrease in membrane resistance upon reduction of extracellular calcium was detected in electrophysiological studies of antisense transfectants, in contrast to control cells. Studies of dye uptake in HeLa cells also demonstrated a large increase following transfection with Cx43. Together these observations indicate that Cx43 is responsible for the hemichannel function in these cultured cells. Similar dye uptake results were obtained with normal rat kidney (NRK) cells, which express Cx43. Dye uptake can be dramatically inhibited by 12-O-tetradeconylphorbol-13-acetate-activated protein kinase C in these cell systems and by a temperature-sensitive tyrosine protein kinase, pp60v-src in LA25-NRK cells. We conclude that Cx43 hemichannels are found in the plasma membrane, where they are regulated by multiple signaling pathways, and likely represent an important stage in gap junction assembly.
Pathophysiology of Ménière's Syndrome: Are Symptoms Caused by Endolymphatic Hydrops?

Background: The association of Ménière's syndrome with endolymphatic hydrops has led to the formation of a central hypothesis: many possible etiologic factors lead to hydrops, and hydrops in turn generates the symptoms. However, this hypothesis of hydrops as being the final common pathway has not been proven conclusively. Specific Aim: To examine human temporal bones with respect to the role of hydrops in causing symptoms in Ménière's syndrome. If the central hypothesis were true, every case of Ménière's syndrome should have hydrops and every case of hydrops should show the typical symptoms. Methods: Review of archival temporal bone cases with a clinical diagnosis of Ménière's syndrome (28 cases) or a histopathologic diagnosis of hydrops (79 cases). Results: All 28 cases with classical symptoms of Ménière's syndrome showed hydrops in at least one ear. However, the reverse was not true. There were 9 cases with idiopathic hydrops and 10 cases with secondary hydrops, but the patients did not exhibit the classic symptoms of Ménière's syndrome. A review of the literature revealed cases with asymptomatic hydrops (similar to the current study), as well as cases where symptoms of Ménière's syndrome existed during life but no hydrops was observed on histology. We also review recent experimental data where obstruction of the endolymphatic duct in guinea pigs resulted in cytochemical abnormalities within fibrocytes of the spiral ligament before development of hydrops. This result is consistent with the hypothesis that hydrops resulted from disordered fluid homeostasis caused by disruption of regulatory elements within the spiral ligament. Conclusion: Endolymphatic hydrops should be considered as a histologic marker for Ménière's syndrome rather than being directly responsible for its symptoms.
Knowing How vs. Knowing That

More than forty years after Gilbert Ryle published his paper on "Knowing How and Knowing That" in 1945, 1 the problem of practical knowledge has still failed to establish for itself a secure position in the field of problems dealt with by analytic philosophers. Thus even today it can safely be asserted that it is discursive or theoretical knowledge, knowledge linguistically expressed, above all knowledge in the form of propositions, that holds centre stage in analytic treatments of epistemology and cognition. The present volume, which consists of treatments of the presuppositions and specific character of practical knowledge in different spheres, is an attempt to fill this gap. The successive chapters fall into four interrelated groups: (1) those dealing with general theoretical problems associated with knowledge and practice and their interrelations ; (2) those dealing with habit, learning, technique and skill as social phenomena, phenomena tied to socially established traditions and customs; (3) those dealing with that special kind of practical knowledge which is manifested in our use of language; and (4) those dealing with the role of practical knowledge and of tradition in the sphere of art.
In silico identification of vaccine candidates against enteric pathogens by a comparative genome sequence approach

Enteropathogens are among the most important human pathogens. Enteric pathogens including Shigella spp, Es- cherichia coli, Vibrio cholerae, Salmonella spp. and Yersinia enterocolitica account for a significant percentage of diarrheal diseases in the developing world. The antigenic diversity among various circulating strains of these pathogens is a cause of concern to those developing effective vaccines. In this context, we searched for any conserved bacterial cell surface located proteins which are shared among most of the above mentioned pathogens that could be used as potential vaccine candidates to neutralize most of them if not all of them. Various in silico procedures were applied to identify such vaccine candidates by adopting a scheme of stepwise eliminations. The study resulted in identifying total 11 expressed (protein producing) genes of interest; of these 3 appeared to be strong vaccine candidates, and could also act as good diagnostic markers for discrimination of closely related diarrheagenic bacterial species.
On Conditions for Morphogenetic Diversity of Multicellular Organisms

In a multicellular organism, a single cell—an egg—or a group of cells develops into a certain pattern with a variety of cell types. The variety of cell types are created through cell differentiation; the differentiation starts from an initial type, and then the initial type changes into several intermediate types before differentiating into the final type. Theoretical study of cell differentiation and morphogenesis was pioneered by Alan Turing, who showed that a reaction–diffusion system can produce an inhomogeneous stable pattern [4]. Turing’s theory provides a basis of dynamical system for morphogenesis and potentiality of cell differentiation. Embryogenesis with increases of cell numbers was, however, not studied. By considering Turing’s study and intracellular dynamics, together with the cell division process to increase the cell numbers, Kaneko and Yomo have proposed isologous diversification [2, 3]. This allows the spontaneous cell differentiation through cell division processes and cell–cell interactions. These studies provide a basis for morphogenetic diversity of multicellular organisms. However, relevance of proliferation rates and transition rates between cell types to morphogenetic diversity has not been studied. In this paper, we shall answer this question by constructing the model based on probabilistic Lindenmayer system with interaction and by using quantifier elimination (abbreviated to QE) [6].
The Gendering of Compassion in Organizations

To better understand compassion as a social and cultural process, I examine the influence of gender on the appraisal of and response to women suffering in the workplace. I propose that not only does the gendered performance of suffering impact the compassion process but examine the performance of compassion in the workplace more broadly. I examine the practice of compassion towards women in organizations and propose ways to elevate the compassion process, as well as develop a compassion intervention to practice the doing of compassion and enhance understanding about its importance.
The Development of Experimental Curriculum to Effect the Political Socialization of Anglo, Black, and Mexican-American Adolescents. Final Report.

AUTHOR Button, Christine Bennett TITLE The Development of Experimental Curriculum to Effect the Political Socialization of Anglo, Black, and Mexican-American Adolescents. Final Report. SPONS AGENCY National Center for Educational Research and Development (DHEW/OE), Washington, D.C. BUREAU NO BR-1-F-075 PUB DATE May 7 2 CONTRACT OEC-6-71-0531-509 NOTE 188p. ; Doctoral Dissertation, University of Texas, 1972
Regulatory Enforcement, Politics, and Institutional Distance: OSHA Inspections 1990-2010

We explore the determinants of inspection outcomes across 1.6 million Occupational Safety and Health Agency audits from 1990 through 2010. We find that discretion in enforcement differs in state and federally conducted inspections. State agencies are more sensitive to local economic conditions, finding fewer standard violations and fewer serious violations as unemployment increases. Larger companies receive greater lenience in multiple dimensions. Inspector issued fines and final fines, after negotiated reductions, are both smaller during Republican presidencies. Quantile regression analysis reveals that Presidential and Congressional party affiliations have their greatest impact on the largest negotiated reductions in fines.
Journal of Personality and Social Psychology Exploring Individual Differences in Reactions to Mortality Salience: Does Attachment Style Regulate Terror Management Mechanisms?

Five studies examined the contribution of attachment style to mortality salience effects. In Study 1, mortality salience led to more severe judgments of transgressions only among anxious-ambivalent and avoidant persons but not among secure persons. In addition, whereas anxious-ambivalent persons showed immediate and delayed increases in severity judgments, avoidant persons showed this response only after a delay period. In Study 2, anxious-ambivalent persons showed immediate and delayed increases in death-thought accessibility after death reminders. Avoidant and secure persons showed this effect only after a delay period. Study 3 revealed that worldview defense in response to mortality salience reduced death-thought accessibility only among avoidant persons. Studies 4-5 revealed that mortality salience led to an increase in the sense of symbolic immortality as well as in the desire of intimacy only among secure persons, but not among avoidant and anxious-ambivalent persons. seems to be a promising framework for explaining human behavior in terms of defensive motivations related to death awareness. Research has shown that death reminders lead people to embrace cultural worldviews and that certain individual differ-TMT research, we focus on the moderating role of a yet unex-plored but theoretically relevant individual difference factor: attachment style. This factor seems to affect the way people emotionally react to stressful situations as well as to the terror of death awareness (Mikulincer & Florian, 1998). TMT TMT (Greenberg et al., 1997) assumes that death awareness is a major source of anxiety and that the management of the impinging terror seems to be achieved by two psychological mechanisms. The first mechanism consists of the validation of one's cultural worldview. According to TMT, cultural worldview validation imbues the world with order and meaning and provides both a set of standards of value and behavior and the promise of death tran-scendence (Solomon et al., 1991). The second mechanism consists of efforts aimed at increasing self-esteem by living up to those standards of value prescribed by the Culture. Along this reasoning, the mortality salience hypothesis has been formulated (e.g., So-lomon et al., 1991), by which people exposed to death reminders would react positively to ideas and people that validate the cultural worldview and negatively to ideas and people that deviate from 260 this woddview. Moreover, mortality salience would lead people to attempt to maintain or enhance self-esteem. The mortality salience hypothesis h~been validated in several studies. Death reminders have been found to lead to more negative evaluations of out-group …
Eddy-Current Sensors with Asymmetrical Point Spread Function

This paper concerns a special type of eddy-current sensor in the form of inductive loops. Such sensors are applied in the measuring systems classifying road vehicles. They usually have a rectangular shape with dimensions of 1 × 2 m, and are installed under the surface of the traffic lane. The wide Point Spread Function (PSF) of such sensors causes the information on chassis geometry, contained in the measurement signal, to be strongly averaged. This significantly limits the effectiveness of the vehicle classification. Restoration of the chassis shape, by solving the inverse problem (deconvolution), is also difficult due to the fact that it is ill-conditioned. An original approach to solving this problem is presented in this paper. It is a hardware-based solution and involves the use of inductive loops with an asymmetrical PSF. Laboratory experiments and simulation tests, conducted with models of an inductive loop, confirmed the effectiveness of the proposed solution. In this case, the principle applies that the higher the level of sensor spatial asymmetry, the greater the effectiveness of the deconvolution algorithm.
3.3GHz Phase locked loop with four multiple output using 45nm CMOS Technology

This paper present area efficient layout design for 3.3GigaHertz (GHz) Phase Locked loop (PLL) with four multiple output. Effort has been taken to design Low Power Phase locked loop with multiple output, using VLSI technology. VLSI Technology includes process design, trends, chip fabrication, real circuit parameters, circuit design, electrical characteristics, configuration building blocks, switching circuitry, translation onto silicon, CAD and practical experience in layout design. The proposed PLL is designed using 45 nm CMOS/VLSI technology with microwind 3.1. This software allows designing and simulating an integrated circuit at physical description level. The main novelties related to the 45 nm technology are the high-k gate oxide, metal gate and very low-k interconnect dielectric. The effective gate length required for 45 nm technology is 25nm. Low Power (0.211miliwatt) phase locked loop with four multiple outputs as PLL8x, PLL4x, PLL2x, & PLL1x of 3.3 GHz, 1.65 GHz, 0.825 GHz, and 0.412 GHz respectively is obtained using 45 nm VLSI technology.
Numerical Methods for Sparse Recovery

These lecture notes address the analysis of numerical methods for performing opti- mizations with linear model constraints and additional sparsity conditions to solutions, i.e., we expect solutions which can be represented as sparse vectors with respect to a prescribed basis. In the first part of the manuscript we illustrate the theory of compressed sensing with emphasis on computational aspects. We present the analysis of the homotopy method, the iteratively re-weighted least squares method, and the iterative hard-t hresholding. In the second part, start- ing from the analysis of iterative soft-thresholding, we il lustrate several numerical methods for addressing sparse optimizations in Hilbert spaces. The third and final part is concerned with numerical techniques, based on domain decomposition methods, for dimensionality reduction in large scale computing. In the notes we are mainly focusing on the analysis of the algorithms, and we report a few illustrative numerical examples.
Survivable traffic grooming in elastic optical networks — Shared path protection

This study investigates the survivable traffic grooming problem for elastic optical networks with flexible grid employing new transmission technologies, e.g., orthogonal frequency-division multiplexing (OFDM). In such networks, the strict ITU-T wavelength grid is not followed. Instead, optical transponders are developed to be capable of properly tuning their rates. Equipping the network with gridless and elastic optical paths allows us to efficiently use the optical spectrum. In this paper, we propose a novel elastic shared path protection (ESPP), which does not only provide the traditional backup sharing of shared path protection (SPP) (i.e., the backup capacity of one optical path (i.e., lightpath) can be shared among multiple backup paths, provided that their corresponding working paths are link-disjoint), but also explores a new opportunity of sharing enabled by the tunability of the transponders: in fact, the backup spectrum can be shared between two adjacent lightpaths on a link, if their corresponding working paths are link-disjoint. The elasticity of the transponder enables the expansion and contraction of the lightpaths, so that at one time, the backup spectrum is used by only one of the adjacent lightpaths. Note that in traditional wavelength-division-multiplexing (WDM) networks, the lightpaths are fixed-grid, rigid-bandwidth, nor can they overlap each other. Our results show that ESPP is more spectrum efficient than traditional SPP.
Metamodels without Metacircularities

Bien que les langages de modelisation comme l'UML (Unified Modeling Language) soient utilises en premier lieu pour le developpement de logiciel, il y a d'autres possibilites d'application. Un exemple tres connu est la definition des langages, par exemple l'UML est defini partiellement par l'UML. Cette methode de metamodelisation est devenue populaire parce qu'elle offre beaucoup d'avantages; mais sa metacircularite reste un de ses plus gros inconvenients. Cette etude propose un procede qui permet de formuler des metamodeles tout en excluant la metacircularite. Le fond de cette etude constitue le formalisme CINV qui est semblable a l'UML qui se definit formellement sur la theorie des ensembles et qui sert de metalangage pour definir la syntaxe et la semantique de l'UML Dans cette etude, nous nous concentrons sur l'application de CINV pour la description de la syntaxe abstraite d'un langage. En particulier, nous comparons nos descriptions de CINV avec des metamodeles semblables formules en l'UML. Cette comparaison montre plusieurs desavantages de l'UML quand il est utilise en tant que metalangage.