Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Sublingual Application of Cannabinoids on Intraocular Pressure: A Pilot Study

PurposeThe purpose of this study was to assess the effect on intraocular pressure (IOP) and the safety and tolerability of oromucosal administration of a low dose of delta-9-tetrahydrocannabinol (Δ-9-THC) and cannabidiol (CBD). Patients and MethodsA randomized, double-masked, placebo-controlled, 4 way crossover study was conducted at a single center, using cannabis-based medicinal extract of Δ-9-THC and CBD. Six patients with ocular hypertension or early primary open angle glaucoma received a single sublingual dose at 8 AM of 5 mg Δ-9-THC, 20 mg CBD, 40 mg CBD, or placebo. Main outcome measure was IOP. Secondary outcomes included visual acuity, vital signs, and psychotropic effects. ResultsTwo hours after sublingual administration of 5 mg Δ-9-THC, the IOP was significantly lower than after placebo (23.5 mm Hg vs. 27.3 mm Hg, P=0.026). The IOP returned to baseline level after the 4-hour IOP measurement. CBD administration did not reduce the IOP at any time. However, the higher dose of CBD (40 mg) produced a transient elevation of IOP at 4 hours after administration, from 23.2 to 25.9 mm Hg (P=0.028). Vital signs and visual acuity were not significantly changed. One patient experienced a transient and mild paniclike reaction after Δ-9-THC administration. ConclusionsA single 5 mg sublingual dose of Δ-9-THC reduced the IOP temporarily and was well tolerated by most patients. Sublingual administration of 20 mg CBD did not reduce IOP, whereas 40 mg CBD produced a transient increase IOP rise.
Arm lymphoscintigraphy after axillary lymph node dissection or sentinel lymph node biopsy in breast cancer

Purpose Compare the lymphatic flow in the arm after breast cancer surgery and axillary lymph node dissection (ALND) versus sentinel lymph node biopsy (SLNB) using lymphos-cintigraphy (LS). Patients and methods A cross-sectional study with 39 women >18 years who underwent surgical treatment for unilateral breast cancer and manipulation of the axillary lymph node chain through either ALND or SLNB, with subsequent comparison of the lymphatic flow of the arm by LS. The variables analyzed were the area reached by the lymphatic flow in the upper limb and the sites and number of lymph nodes identified in the ALND or SLNB groups visualized in the three phases of LS acquisition (immediate dynamic and static images, delayed scan images). For all analyses, the level of significance was set at 5%. Results There was a significant difference between the ALND and SLNB groups, with predominant visualization of lymphatic flow and/or lymph nodes in the arm and axilla (P=0.01) and extra-axillary lymph nodes (P<0.01) in the ALND group. There was no significant difference in the total number of lymph nodes identified between the two groups. However, there was a significant difference in the distribution of lymph nodes in these groups. The cubital lymph node was more often visualized in the immediate dynamic images in the ALND group (P=0.004), while the axillary lymph nodes were more often identified in the delayed scan images of the SLNB group (P<0.01). The deltopectoral lymph node was only identified in the ALND group, but with no significant difference. Conclusion The lymphatic flow from the axilla was redirected to alternative extra-axillary routes in the ALND group.
PhotoReply: Automatically Suggesting Conversational Responses to Photos

We introduce the problem of automatically suggesting conversational responses to photos and present an intelligent assistant called PhotoReply that solves the problem in the context of a messaging application. For example, when a user receives a photo showing a dog, PhotoReply suggests responses such as "Aww»» and "Cute terrier! »» This simplifies composing responses on constrained mobile keyboards, and delights users with uncanny insights into the photos they receive. PhotoReply is an integral part of the Allo chat application, being its predictive assistance feature with highest click-through rate. We formalize the problem of suggesting responses to images as an instance of multimodal learning which is akin to caption generation models, a topic that has recently received significant attention \citeKarpathy2015,Vinyals2015,Xu2015. We then present a system that "translates»» image pixels to text responses. The system includes a conditioned language model, based on an LSTM, which, given an embedding of image pixels and the previous predicted words, calculates the probability of all words in a vocabulary of being the next word in the generated response and a triggering model trained with image embeddings and concept labels from a large concept taxonomy. We describe training of the models and a thorough experimental evaluation based on crowdsourced datasets and live traffic.
A POSTERIORI ANALYSIS OF AN ITERATIVE ALGORITHM FOR NAVIER-STOKES PROBLEM

This work deals with a posteriori error estimates for the Navier-Stokes equations. We propose a finite element discretization relying on the Galerkin method and we solve the discrete problem using an iterative method. Two sources of error appear, the discretization error and the linearization error. Balancing these two errors is very important to avoid performing an excessive number of iterations. Several numerical tests are provided to evaluate the efficiency of our indicators.
Current perspectives on therapeutic ultrasound in the management of chronic wounds: a review of evidence

: Although therapeutic ultrasound has been in existence since the 1930s, questions remain as to its effectiveness in promoting tissue healing in various injured tissues. These tissues include soft tissues such as skin, tendons, ligaments, bursae, joint capsules and muscles. Limited evidence exists to support a role for therapeutic ultrasound in closed, soft tissue lesions. However, an evolving literature provides support for the role of therapeutic ultrasound in the treatment of chronic wounds, acute injuries such as fractures and split thickness graft donor sites as well as in the modulation of wound-related pain. Modern technology that uses low-frequency (kilohertz), long wave ultrasound appears promising compared to older, higher frequency ultrasound (megahertz) devices. These newer devices appear to have positive effects on healing rates in various wound types, pain levels and the modulation of proinflammatory cytokines. Venous Substantial mean reduction in pain in the ultrasound plus SOC group; Non significant changes in wound area, infections and QoL.
BIOSYNTHESIS OF SILVER NANOPARTICLES FROM AQUEOUS EXTRACT OF BAUHINIA ACUMINATA USING VARIOUS PHYSICAL PARAMETERS AND ITS APPLICATIONS

Bauhinia acuminata, from southwestern region of Kerala medicinally important in traditional system of medicine and are used as an effective natural drug. To synthesize silver nanoparticle from Bauhinia acuminata aqueous leaf extract obtained by changing different reaction parameters such as temperature, reaction time, varying ratio and concentration of plant extract and precursor (AgNO3). The characterization of Bauhinia acuminata silver nanoparticle using UVVis spec. Now days microbial resistance to antibiotics is a serious concern in medicine. The use of silver nanoparticles (AgNPs) as a potent antibacterial agent has received much attention. BAAgNPs have multiple targets and found to be effective against C. freundi and M. luteus was found to be <1000 and 750 μg using MIC assay. The molecular docking affinity of Phytol ligand binding to cellular receptors like 5DZL with -2.53 kcal/mol shows the effective nature of the aqueous leaf extract components. The BaAgNPs shows the effective antimicrobial inhibition against E.coli and S.aureus.
Programmable nanophotonics for quantum information processing and artificial intelligence

Over the past decade, progress in digital electronic computing systems has slowed as traditional, transistor-based silicon technologies approach their scaling limits. Quantum computing and non-Von Neumann computing architectures have emerged as promising alternatives for continued computational advancement-garnering significant investment and public interest. As a hardware platform, silicon photonics may play an important role in enabling quantum and classical information processing architectures. Here, I will discuss my thesis work on developing a programmable nanophotonic processor in silicon, as well as applications of this processor within the fields of quantum simulation, quantum computing, and deep learning. I will also cover results on environment-assisted quantum transport, deep learning with coherent nanophotonics, heralded single-photon sources, and highly integrable superconducting nanowire single-photon detectors. Thesis Supervisor: Dirk R. Englund Title: Associate Professor
Antigen-loaded chitosan nanoparticles for immunotherapy

The invention discloses antigen-loaded chitosan nanoparticles for immunotherapy. The present invention is directed to nanoparticles comprising chitosan and an antigen, whereby the chitosan has a degree of deacetylation of about 90% and a molecular weight from 5 kDa to 80 kDa, to microparticles containing such nanoparticles as well as to a process for preparation of such particles. The particles are usable for vaccination.
Development of turbulent boundary layer in sudden change of depressed surface roughness

The development of turbulent boundary layer over a flat surface with sudden increase in roughness was investigated experimentally. The effect of roughness orientation, upstanding or depressed was also studied. The experiment was ~arriedout in a 18 in. x 18 in. wind tunnel. Roughening elements comprised of stone chips of average size of 0.625 in. The flow parameters were measured at three Reynolds numbers viz.8. 74 x 105,5.06 x 105, 2.56 x 105. Heasurement of boundary layer parameters was done by pitot static tube. It was observed that although the ~riction factor and shear stress is independent of the roughness orientation, the grow.th rate . of internal boundary lay~r is slower with depressed roughness than that with upstanding one. The flow was not fully developed even after 5.0 diameters of wind tunnel downstream from the sr"ooth rough junction. In. both the cases sharp drop in axial pressure indicated high dissipation of flow energy in the transition zone .
INESC-ID@ASSIN: Medição de Similaridade Semântica e Reconhecimento de Inferência Textual

In this article we present INESC-ID@ASSIN, a system that competed in the 2016 joint evaluation effort entitled Avaliacao de Similaridade Semântica e Inferencia Textual (ASSIN), in the tasks of semantic similarity and textual entailment recognition. INESC-ID@ASSIN addresses the problem of detecting sentence similarity as a regression task, and it addresses textual entailment as a classification task. Although INESC-ID@ASSIN relies mainly on simple lexical features for detecting paraphrases and recognizing textual entailment, promising results were achieved in this joint evaluation.
Feature Propagation on Graph: A New Perspective to Graph Representation Learning

We study feature propagation on graph, an inference process involved in graph representation learning tasks. It's to spread the features over the whole graph to the $t$-th orders, thus to expand the end's features. The process has been successfully adopted in graph embedding or graph neural networks, however few works studied the convergence of feature propagation. Without convergence guarantees, it may lead to unexpected numerical overflows and task failures. In this paper, we first define the concept of feature propagation on graph formally, and then study its convergence conditions to equilibrium states. We further link feature propagation to several established approaches such as node2vec and structure2vec. In the end of this paper, we extend existing approaches from represent nodes to edges (edge2vec) and demonstrate its applications on fraud transaction detection in real world scenario. Experiments show that it is quite competitive.
Hybrid impedance control for multi-segmented inspection robot Kairo-II

The tremendous redundancy of the multi-segmented robot Kairo-II can be utilized to enhance general robot configuration by any inspection task. To do so, an extensive control scheme must be installed which can handle both, contact scenarios with the environment and ambiguous robot configurations. A method for implementing an appropriate scheme using Transposed Jacobians based on Hybrid Impedance Control (TJ-HIC) is described and validated for multi-segmented robots. Crucial parts of this model are identified and implemented. These are dynamic modeling of the robot in Recursive Newton-Euler equations (RNE) and a sensory system for apropriate force feedback information.
l-Glutamine Attenuates Apoptosis in Porcine Enterocytes by Regulating Glutathione-Related Redox Homeostasis.

Background Programmed cell death plays a fundamental role in intestinal development and mucosal homeostasis. Dysregulation of these processes is associated with an impaired intestinal-mucosal barrier, reduced nutrient absorption, and initiation and progression of intestinal diseases. 4-Hydroxy-2-nonenal (4-HNE), a product of lipid peroxidation, is commonly used to induce oxidative stress in cells. l-Glutamine is known to protect cells from apoptosis. However, the underlying mechanisms are largely unknown. Objective This study was conducted to test the hypothesis that l-glutamine attenuates 4-HNE-induced apoptosis by modulating glutathione (GSH) and thioredoxin (TXN) antioxidant systems and the expression of genes involved in 4-HNE metabolism in enterocytes. Methods Intestinal porcine epithelial cell line 1 (IPEC-1) cells were cultured with or without 4-HNE (30 μmol/L) in the presence of 0.05 or 0.25 mmol l-glutamine/L (a physiological concentration in the lumen of the small intestine) for indicated time periods. Cell viability, abundances of apoptotic proteins, mitochondrial membrane depolarization, production of reactive oxygen species (ROS) and GSH, and expression of genes involved in the biosynthesis of GSH, thioredoxin, and 4-HNE metabolism were determined. Results Compared with basal medium containing 0.05 mmol l-glutamine/L, 4-HNE enhanced apoptosis by 19.6% (P < 0.05) in a caspase-3-dependent manner. This effect was accompanied by elevated intracellular ROS production (39.5% and 85.3% for 2- and 4-h treatment, respectively), increased mitochondrial depolarization by 80%, and decreased intracellular GSH concentrations by 17.7%. These effects of 4-HNE were reduced by 0.25 mmol l-glutamine/L. Further study showed that the protective effect of l-glutamine was associated with the enhanced expression of genes involved in GSH production (including GCLC, GCLM, GSR, CBS, and CTH) by 3.9-14-fold, as well as genes involved in 4-HNE metabolism [e.g., glutathione S-transferase A (GSTA)1 and GSTA4] by 1.9-7.2-fold. The mRNA levels for ADH5, AKR1C1, AKR1A1, and TXNRD1 were enhanced 1.4-8.8-fold by 4-HNE but were not changed in cells co-treated with 4-HNE and l-glutamine. Conclusion These findings indicate that l-glutamine attenuates 4-HNE-induced apoptosis by regulating GSH-related redox homeostasis and enhancing GSTA-mediated metabolism in enterocytes.
Development of a real-time repeated-measures assessment protocol to capture change over the course of a drinking episode.

AIMS We report on the development of a real-time assessment protocol that allows researchers to assess change in BrAC, alcohol responses, behaviors, and contexts over the course of a drinking event. METHOD We designed a web application that uses timed text messages (adjusted based on consumption pattern) containing links to our website to obtain real-time participant reports; camera and location features were also incorporated into the protocol. We used a transdermal alcohol sensor device along with software we designed to convert transdermal data into estimated BrAC. Thirty-two college students completed a laboratory session followed by a 2-week field trial. RESULTS Results for the web application indicated we were able to create an effective tool for obtaining repeated measures real-time drinking data. Participants were willing to monitor their drinking behavior with the web application, and this did not appear to strongly affect drinking behavior during, or 6 weeks following, the field trial. Results for the transdermal device highlighted the willingness of participants to wear the device despite some discomfort, but technical difficulties resulted in limited valid data. CONCLUSION The development of this protocol makes it possible to capture detailed assessment of change over the course of naturalistic drinking episodes.
Bamboo-like Chained Cavities and Other Halogen-Bonded Complexes from Tetrahaloethynyl Cavitands with Simple Ditopic Halogen Bond Acceptors

Halogen bonding provides a useful complement to hydrogen bonding and metal-coordination as a tool for organizing supramolecular systems. Resorcinarenes, tetrameric bowl-shaped cavitands, have been previously shown to function as efficient scaffolds for generating dimeric capsules in both solution and solid-phase, and complicated one-, two-, and three-dimensional frameworks in the solid phase. Tetrahaloethynyl resorcinarenes (bromide and iodide) position the halogen atoms in a very promising “crown-like” orientation for acting as organizing halogen-bond donors to help build capsules and higher-order networks. Symmetric divalent halogen bond acceptors including bipyridines, 1,4-dioxane, and 1,4-diazabicyclo[2.2. 2]octane are very promising halogen bond accepting partners for creating these systems. This report describes the complex structures arising from combining these various systems including self-included dimers, herringbone-packed architectures enclosing medium (186 A3) cavities, and a very intriguing .
Increased Use of Twitter at a Medical Conference: A Report and a Review of the Educational Opportunities

Background Most consider Twitter as a tool purely for social networking. However, it has been used extensively as a tool for online discussion at nonmedical and medical conferences, and the academic benefits of this tool have been reported. Most anesthetists still have yet to adopt this new educational tool. There is only one previously published report of the use of Twitter by anesthetists at an anesthetic conference. This paper extends that work. Objective We report the uptake and growth in the use of Twitter, a microblogging tool, at an anesthetic conference and review the potential use of Twitter as an educational tool for anesthetists. Methods A unique Twitter hashtag (#WSM12) was created and promoted by the organizers of the Winter Scientific Meeting held by The Association of Anaesthetists of Great Britain and Ireland (AAGBI) in London in January 2012. Twitter activity was compared with Twitter activity previously reported for the AAGBI Annual Conference (September 2011 in Edinburgh). All tweets posted were categorized according to the person making the tweet and the purpose for which they were being used. The categories were determined from a literature review. Results A total of 227 tweets were posted under the #WSM12 hashtag representing a 530% increase over the previously reported anesthetic conference. Sixteen people joined the Twitter stream by using this hashtag (300% increase). Excellent agreement (κ = 0.924) was seen in the classification of tweets across the 11 categories. Delegates primarily tweeted to create and disseminate notes and learning points (55%), describe which session was attended, undertake discussions, encourage speakers, and for social reasons. In addition, the conference organizers, trade exhibitors, speakers, and anesthetists who did not attend the conference all contributed to the Twitter stream. The combined total number of followers of those who actively tweeted represented a potential audience of 3603 people. Conclusions This report demonstrates an increase in uptake and growth in the use of Twitter at an anesthetic conference and the review illustrates the opportunities and benefits for medical education in the future.
Dietary n 2 3 and n 2 6 polyunsaturated fatty acid intake interacts with FADS 1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study 1 – 3

Background: The d-5 and d-6 desaturases, encoded by the FADS1 and FADS2 genes, are rate-limiting enzymes in polyunsaturated fatty acid (PUFA) biosynthesis. Single nucleotide polymorphisms in the FADS gene cluster region have been associated with both PUFA concentrations in plasma or erythrocyte membrane phospholipids and cholesterol concentrations in recent genome-wide association studies. Objective: We examined whether genetic variations in the FADS gene cluster region interact with dietary intakes of n23 (omega-3) and n26 (omega-6) PUFAs to affect plasma total, HDL-, and nonHDL-cholesterol concentrations. Design: Dietary intakes of n23 and n26 PUFAs, plasma concentrations of total and HDL cholesterol, and rs174546, rs482548, and rs174570 in the FADS gene cluster region were measured in 3575 subjects in the second survey of the Doetinchem Cohort Study. Results: Significant associations between rs174546 genotypes and total and non-HDL-cholesterol concentrations were observed in the group with a high intake of n23 PUFAs ( 0.51% of total energy; P = 0.006 and 0.047, respectively) but not in the low-intake group (P for interaction = 0.32 and 0.51, respectively). The C allele was associated with high total and non-HDL-cholesterol concentrations. Furthermore, the C allele was significantly associated with high HDL-cholesterol concentrations in the group with a high intake of n26 PUFAs ( 5.26% of total energy, P = 0.004) but not in the group with a low intake (P for interaction = 0.02). Conclusion: Genetic variation in the FADS1 gene potentially interacts with dietary PUFA intakes to affect plasma cholesterol concentrations, which should be investigated further in other studies. Am J Clin Nutr 2010;92:258–65.
Using object capabilities and effects to build an authority-safe module system: poster

The principle of least authority states that each component of a software system must have only the authority necessary for its execution and nothing else. This principle is a cornerstone of the security of software applications, but it is difficult to enforce in practice. Current programming languages, as well as non-linguistic approaches, do not provide adequate control over the authority of untrusted modules [1, 5]. To fill this gap, we designed and implemented a capability-based module system that facilitates controlling the security capabilities of software modules [2]. Furthermore, we are currently working on augmenting our module system with an effect system to make our design authority-safe. Our approach simplifies the process of ensuring that a software system maintains the principle of least authority, and also allows for attenuation of module authority [3]. Our design is implemented as part of the Wyvern programming language [4].