Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of High-sulfate Water on Trace Mineral Status of Beef Steers

Two experiments were conducted to determine the effect of high-sulfate water on the performance, health, and mineral status of growing steers. The first experiment was conducted from June 20 to September 12, 2001, at the South Dakota State University (SDSU) Cottonwood Range and Livestock Research Station. Eighty-one crossbred steers (initial BW = 700 lb) were stratified by weight and randomly assigned to 12 dry-lot pens (6 or 7 steers/pen). Pens were then randomly assigned to one of three water quality treatments: 1) rural water (404 ppm sulfate), 2) well water (3087 ppm sulfate), and 3) stock dam water (3947ppm sulfate). Steers were fed a diet consisting of grass hay and pelleted wheat middlings. The second experiment was conducted from May 23 to September 4, 2002, at the SDSU Cottonwood Range and Livestock Research Station. Eightyfour crossbred steers (initial BW = 640 lb) were stratified by weight and randomly assigned to 12 dry-lot pens (7 steers/pen). Pens were then randomly assigned to one of four water quality treatments: 1) 1000, 2) 3000, 3) 5000, and 4) 7000 ppm total dissolved solids. These treatment levels were created by mixing water of varying quality from three different natural sources. Steers were fed a diet consisting of grass hay and pelleted wheat middlings. In both experiments, initial and final liver biopsy samples were collected. Liver samples were analyzed for copper (Cu), iron (Fe), manganese (Mn), molybdenum (Mo), and zinc (Zn). In both experiments, initial liver Cu concentrations were not different between treatments. Provision of high-sulfate water reduced liver Cu concentrations in experiment 1 (P < 0.01) and 2 (P < 0.01). Liver Fe, Mn, Mo, and Zn were not affected by treatment. Results of these two experiments clearly demonstrate the dramatic
Statistical classification methodology of SHOALS 3000 backscatter to mapping coastal benthic habitats

The scanning hydrographic operational airborne LiDAR survey (SHOALS) consists of a bathymetric LiDAR system which provides high precision measurements of water depth. Even though the acquisition is focused on depth accuracy, the return signal, i.e. waveform, contains other relevant information because of integration signatures from the water surface, the water column and the sea-bed. This paper highlights the benthic characterization in extracting statistical parameters derived from the bottom backscatter. In applying multivariate analysis (K-means), it is significantly proven that signals derived from habitat, described as statistically homogeneous throughout ground-truth analysis, are (1) similar within an intra-habitat view, while they are (2) different between themselves.
Suitability evaluation of the potential of Ria Kenjeran Beach as marine ecotourism in Surabaya City

Ria Kenjeran Beach (Ken Park) is a beach that has been developed with various types of varios and modern attractions for marine tourism in the city of Surabaya. The limited number of ecotourism and the need for recreation to increase and the large population of Surabaya is a great opportunity. This study aims to evaluate 1) potential seen from attractiveness, accessibility, infrastructure and promotion, 2) coastal area suitability, and 3) development strategies. This study was survey research. The samples selected 100 tourists by using accidental random sampling. Data sources were taken from the result of interviews of respondents and parties involved in managing this area. Data analysis for potential data conducted in scoring, suitability evaluation applied a matrix analysis and strategy of development used SWOT analysis. The results obtained a score of 13,135 in the high category. The value of conformity matrix was 50 including the corresponding criteria (S1). Priority strategies used for ecotourism development are: Increasing the quantity and quality of attractions, Creating rides packages at affordable prices, Improving potential (attractiveness, accessibility and infrastructure), Improving the quality of human resources, Improving promotion, Establishing cooperation with several parties, Improving facilities Infrastructure, Developing attractions that promote local value and are environmentally friendly, Renew attractions and improve quality in order to compete, Improve security, Build integrated cooperation to develop ecotourism, Form a responsible supervisory group.
UC3M: A kernel-based approach to identify and classify DDIs in bio-medical texts.

The domain of DDI identification is constantly showing a rise of interest from scientific community since it represents a decrease of time and healthcare cost. In this paper we purpose a new approach based on shallow linguistic kernel methods to identify DDIs in biomedical manuscripts. The approach outlines a first step in the usage of semantic information for DDI identification. The system obtained an F1 measure of 0.534.
Corpus Research Applications in Second Language Teaching

Over the past few decades, corpora have not only revolutionized linguistic research but have also had an impact on second language learning and teaching. In the field of applied linguistics, more and more researchers and practitioners treasure what corpus linguistics has to offer to language pedagogy. Still, corpora and corpus tools have yet to be widely implemented in pedagogical contexts. The aim of this article is to provide an overview of pedagogical corpus applications and to review recent publications in the area of corpus linguistics and language teaching. It covers indirect corpus applications, such as in syllabus or materials design, as well as direct applications of corpora in the second language classroom. The article aims to illustrate how both general and specialized language corpora can be used in these applications and discusses directions for future research in applied corpus linguistics.
Comment on: Antibiotic stewardship--more education and regulation not more availability?

HPA Clinical Microbiology and Public Health Laboratory, Addenbrooke’s Hospital, Cambridge, UK; Department of Pharmacy, Addenbrooke’s Hospital, Cambridge, UK; Department of Pharmacy, Hammersmith Hospital, Imperial College Healthcare NHS Trust, Imperial College, London, UK; Department of Infectious Diseases, Addenbrooke’s Hospital, Cambridge, UK; Division of Infectious Diseases, Investigative Science, Imperial College, London, UK
Housing and care for older people: life in an English purpose-built retirement village

ABSTRACT Retirement communities are a relatively new long-term accommodation and care option in the United Kingdom. Policy makers and providers endorse the proposition that they are suited for the accommodation of both ‘fit’ and ‘frail’ older people, although comparatively little is known about what it is actually like to live in such communities, about whether they cater adequately for older people with a wide spectrum of needs and abilities, or if they provide acceptable solutions to older people's housing or care needs. This paper addresses these questions by reporting the findings of an independently funded three-year study of a new retirement village, Berryhill, in the north Midlands of England. The paper examines the background to this and similar developments, details how the study was carried out, and then examines what it was like to live at Berryhill. It focuses on the housing and care aspects, and explores the residents' motivations for moving to the village; their views about the accommodation; and their use of and satisfaction with the social and leisure amenities. The health and care needs of residents and the formal and informal supports are also featured. The conclusion discusses whether the village can truly be a ‘home for life’ in the face of increasing frailty, and whether or not these new models of accommodation and care can indeed cater for both ‘fit’ and ‘frail’ older people.
Building semantic object maps from sparse and noisy 3D data

We present an approach to create a semantic map of an indoor environment, based on a series of 3D point clouds captured by a mobile robot using a Kinect camera. The proposed system reconstructs the surfaces in the point clouds, detects different types of furniture and estimates their poses. The result is a consistent mesh representation of the environment enriched by CAD models corresponding to the detected pieces of furniture. We evaluate our approach on two datasets totaling over 800 frames directly on each individual frame.
Journal of Economic Behavior & Organization Attention, Intentions, and Follow-through in Preventive Health Behavior: Field Experimental Evidence on Flu Vaccination

Preventive health behaviors like flu vaccination have important benefits, but compliance is poor, and the reasons are not fully understood. We conducted a large study across six colleges (N = 9358), with a methodology that offers an unusual opportunity to look at three potential factors: inattention to information, informed intentions to not comply, and problems following through on intentions. We also tested three interventions in an RCT. We find that inattention to information is not the primary driver of low take-up, while informed decisions to not get the vaccine, but also lack of follow-through, are important factors. A financial intervention increased take-up and had persistent, positive effects on intentions for vaccination in future years. Two low-cost " nudges " did not increase vaccination rates, although the peer endorsement nudge increased exposure to information, especially if aligned with social networks.
Smarcd3 Regulates the Timing of Zebrafish Myogenesis Onset*

A cascade of signaling events triggers myogenesis in vertebrates. Although studies of zebrafish indicate that fibroblast growth factor (Fgf), Hedgehog (Hh), and the T-box transcription factors, No tail (Ntl) and T-box gene 16 (Tbx16), regulate myogenesis, the hierarchy of these factors has not been determined. Recently, another transcriptional cofactor, Smarcd3, a subunit of the SWI/SNF chromatin-remodeling complex, has been shown to be required for heart muscle formation in mouse. In zebrafish, fgf8 and ntl expression commences during blastula stages, whereas myogenesis, as indicated by myod expression, does not begin until much later during mid-gastrula stages. smarcd3b expression, on the other hand, becomes enriched in the marginal zone just prior to the beginning of myod expression. Overexpression of smarcd3 shifts the onset of myod and myf5 expression earlier, and myod and myf5 expression in adaxial cells, the earliest muscle precursors, requires Smarcd3, indicating that Smarcd3 is the limiting factor that regulates the onset of myogenesis. Smarcd3 physically interacts with Ntl, and Smarcd3 overexpression fails to rescue myod expression in ntl mutants, demonstrating that function of Smarcd3 depends on Ntl activity. We propose a model in which cooperative activity of Fgf, Ntl, and Smarcd3 is required for the onset of myogenesis, with Smarcd3b serving as the primary regulator of the timing of myogenesis onset.
Transformed human cells release different fibronectin variants than do normal cells

Fibronectin molecules are dimers composed of subunits whose primary structures may differ. This is due to alternative splicing in at least two regions (ED and IIICS) of the pre-mRNA. Using two monoclonal antibodies specific for two different epitopes of domain 5 (high affinity for heparin), we have quantitatively analyzed the expression of the IIICS sequence in human fibronectins from different sources. The results demonstrated that the percentage of fibronectin subunits containing the IIICS is higher in fibronectins from tumor-derived or simian virus 40-transformed human cells than in fibronectins from human plasma or normal human fibroblasts. Furthermore, we observed that 45- 65% of fibronectin subunits from transformed cells or normal embryonic fibroblasts are sialylated on the heparin-binding domain 5, whereas this occurs in only 24-28% of fibronectin subunits from normal adult fibroblasts. On the contrary, no sialylation was observed on domain 5 in fibronectin from human plasma.
Does Three-dimensional Computer Simulation Improve Results of Scaphoid Nonunion Surgery?

The purpose of this study was to clarify the effectiveness of the three-dimensional computer simulations in scaphoid nonunion surgery. Seven consecutive clinical patients with scaphoid nonunion at the middle third comprised the study group. Surface models of the scaphoid were constructed on the computer using computed tomography data of the bilateral wrists in neutral position. The distal and proximal fragments of the nonunion model were matched to the mirror image of the contralateral scaphoid model. The rotation of the distal fragment relative to the proximal fragment was calculated, and reduction of the displaced fragment of the scaphoid nonunion was simulated. Similarly, the estimated bone defect and the appropriate site and direction of the screw insertion were simulated. Full-sized hard models of the bone, including a model with simulated reduction and screw insertion, then were made using stereolithography based on the computer data. In the actual surgery, reduction, bone grafting, and screw insertion were achieved using the hard models as guides. All the patients obtained solid bone fusion and substantial clinical improvement with normalized scapholunate and radiolunate angles after surgery. Three-dimensional computer simulations were found as useful for accurate correction of scaphoid nonunions and proper screw placement, which consequently leads to good clinical results.
Phosphatidic Acid Regulates Microtubule Organization by Interacting with MAP65-1 in Response to Salt Stress in Arabidopsis[C][W]

A plant phospholipase D (PLDα1) is activated by salt stress, and the produced lipid phosphatidic acid (PA) binds to a microtubule-associated protein MAP65-1. The PA and MAP65-1 interaction is essential for the regulation of microtubule organization and salt tolerance. This finding couples lipid signaling to the cytoskeleton and reveals a lipid-mediated signaling pathway that responds to stress. Membrane lipids play fundamental structural and regulatory roles in cell metabolism and signaling. Here, we report that phosphatidic acid (PA), a product of phospholipase D (PLD), regulates MAP65-1, a microtubule-associated protein, in response to salt stress. Knockout of the PLDα1 gene resulted in greater NaCl-induced disorganization of microtubules, which could not be recovered during or after removal of the stress. Salt affected the association of MAP65-1 with microtubules, leading to microtubule disorganization in pldα1cells, which was alleviated by exogenous PA. PA bound to MAP65-1, increasing its activity in enhancing microtubule polymerization and bundling. Overexpression of MAP65-1 improved salt tolerance of Arabidopsis thaliana cells. Mutations of eight amino acids in MAP65-1 led to the loss of its binding to PA, microtubule-bundling activity, and promotion of salt tolerance. The pldα1 map65-1 double mutant showed greater sensitivity to salt stress than did either single mutant. These results suggest that PLDα1-derived PA binds to MAP65-1, thus mediating microtubule stabilization and salt tolerance. The identification of MAP65-1 as a target of PA reveals a functional connection between membrane lipids and the cytoskeleton in environmental stress signaling.
Phytochrome B Represses Teosinte Branched1 Expression and Induces Sorghum Axillary Bud Outgrowth in Response to Light Signals1

Light is one of the environmental signals that regulate the development of shoot architecture. Molecular mechanisms regulating shoot branching by light signals have not been investigated in detail. Analyses of light signaling mutants defective in branching provide insight into the molecular events associated with the phenomenon. It is well documented that phytochrome B (phyB) mutant plants display constitutive shade avoidance responses, including increased plant height and enhanced apical dominance. We investigated the phyB-1 mutant sorghum (Sorghum bicolor) and analyzed the expression of the sorghum Teosinte Branched1 gene (SbTB1), which encodes a putative transcription factor that suppresses bud outgrowth, and the sorghum dormancy-associated gene (SbDRM1), a marker of bud dormancy. Buds are formed in the leaf axils of phyB-1; however, they enter into dormancy soon after their formation. The dormant state of phyB-1 buds is confirmed by the high level of expression of the SbDRM1 gene. The level of SbTB1 mRNA is higher in the buds of phyB-1 compared to wild type, suggesting that phyB mediates the growth of axillary shoots in response to light signals in part by regulating the mRNA abundance of SbTB1. These results are confirmed by growing wild-type seedlings with supplemental far-red light that induces shade avoidance responses. We hypothesize that active phyB (Pfr) suppresses the expression of the SbTB1 gene, thereby inducing bud outgrowth, whereas environmental conditions that inactivate phyB allow increased expression of SbTB1, thereby suppressing bud outgrowth.
The 3-Bit Gray Counter Based on Magnetic-Tunnel-Junction Elements

A magnetic-tunnel-junction (MTJ) element has been widely studied for data storage applications. An MTJ element can also be used to compute Boolean functions and store the output result. A magnetologic device based on this MTJ element can constitute sequential logic functions as well as combinational logic. Counter is one of the most frequently used sequential logic blocks in digital logic systems. In this paper, a novel architecture of a 3-bit gray counter based on magnetologic elements is presented. It is shown that ten MTJ elements with complementary metal-oxide-semiconductor (CMOS) circuits for sense amplifier and writing-current driver can make a 3-bit gray counter. HSPICE simulation results are presented to verify the functionality of the proposed circuits
Active Suppression of Early Immune Response in Tobacco by the Human Pathogen Salmonella Typhimurium

The persistence of enteric pathogens on plants has been studied extensively, mainly due to the potential hazard of human pathogens such as Salmonella enterica being able to invade and survive in/on plants. Factors involved in the interactions between enteric bacteria and plants have been identified and consequently it was hypothesized that plants may be vectors or alternative hosts for enteric pathogens. To survive, endophytic bacteria have to escape the plant immune systems, which function at different levels through the plant-bacteria interactions. To understand how S. enterica survives endophyticaly we conducted a detailed analysis on its ability to elicit or evade the plant immune response. The models of this study were Nicotiana tabacum plants and cells suspension exposed to S. enterica serovar Typhimurium. The plant immune response was analyzed by looking at tissue damage and by testing oxidative burst and pH changes. It was found that S. Typhimurium did not promote disease symptoms in the contaminated plants. Live S. Typhimurium did not trigger the production of an oxidative burst and pH changes by the plant cells, while heat killed or chloramphenicol treated S. Typhimurium and purified LPS of Salmonella were significant elicitors, indicating that S. Typhimurium actively suppress the plant response. By looking at the plant response to mutants defective in virulence factors we showed that the suppression depends on secreted factors. Deletion of invA reduced the ability of S. Typhimurium to suppress oxidative burst and pH changes, indicating that a functional SPI1 TTSS is required for the suppression. This study demonstrates that plant colonization by S. Typhimurium is indeed an active process. S. Typhimurium utilizes adaptive strategies of altering innate plant perception systems to improve its fitness in the plant habitat. All together these results suggest a complex mechanism for perception of S. Typhimurium by plants.
Sentinel Lymph Node Biopsy for Cutaneous Squamous Cell Carcinoma on the Head and Neck.

Importance Metastasis of cutaneous squamous cell carcinoma (SCC) to the nodal basin is associated with a poor prognosis. The role of sentinel lymph node biopsy (SLNB) for regional staging in patients diagnosed with SCC is unclear. Objective To evaluate a single institution's experience with use of SLNB for regional staging of SCC on the head and neck. Design, Setting, and Participants A retrospective review of 53 patients who were diagnosed with SCC on the head and neck, at high risk for nodal metastasis based on National Comprehensive Cancer Network (NCCN) risk factors, and treated with wide local excision (WLE) and SLNB from December 1, 2010, through January 30, 2015, in a single academic referral center was performed. The follow-up period ended November 5, 2015. Sentinel lymph node biopsy paraffin blocks were retrieved and processed retrospectively with serial sectioning and immunohistochemical analysis (IHC) in cases with nodal recurrence following a negative SLNB. Main Outcomes and Measures Sentinel node (SN) identification rate, SLNB positivity rate, local recurrence, regional nodal recurrence, and distant recurrence. Results In 53 patients with 54 tumors the SN identification rate was 94%. The SLNB positivity rate was 11.3%. On more thorough tissue processing and IHC, metastatic SCC was identified in 2 of 5 (40%) cases previously deemed negative. After reclassification of these cases, the adjusted SLNB positivity rate was 15.1%. The adjusted rate of false omission was 7.1% (95% CI, 2%-19%). Nodal disease developed in 20.8% overall. Angiolymphatic invasion (Cohen d, 3.52; 95% CI, 1.83-5.21), perineural invasion (Cohen d, 0.81; 95% CI, 0.09-1.52), and clinical size (Cohen d, 0.83; 95% CI, 0.05-1.63) were associated with the presence of nodal disease. Conclusions and Relevance Rigorous study of SLNB for cutaneous SCC incorporating prospectively-collected comprehensive data sets based on standardized treatment algorithms is justified with potential to modify clinical practice. Our study demonstrates the critical importance of serial sectioning and IHC of the SLNB specimen for accurate diagnosis. Use of the NCCN guidelines may facilitate identification of patients with SCC at high risk for nodal metastasis.
Objects Extraction by Cooperating Optical Flow, Edge Detection and Region Growing Procedures

— The image segmentation method described in this paper has been developed as a pre-processing stage to be used in methodologies and tools for video/image indexing and retrieval by content. This method solves the problem of whole objects extraction from background and it produces images of single complete objects from videos or photos. The extracted images are used for calculating the object visual features necessary for both indexing and retrieval processes. The segmentation algorithm is based on the cooperation among an optical flow evaluation method, edge detection and region growing procedures. The optical flow estimator belongs to the class of differential methods. It permits to detect motions ranging from a fraction of a pixel to a few pixels per frame, achieving good results in presence of noise without the need of a filtering pre-processing stage and includes a specialised model for moving object detection. The first task of the presented method exploits the cues from motion analysis for moving areas detection. Objects and background are then refined using respectively edge detection and seeded region growing procedures. All the tasks are iteratively performed until objects and background are completely resolved. The method has been applied to a variety of indoor and outdoor scenes where objects of different type and shape are represented on variously textured background.