Miracle-dz/UniFAR-FTUs huggingface dataset:
The remarkable ability of turbulence model equations to describe transition

This paper demonstrates how well the k-omega turbulence model describes the nonlinear growth of flow instabilities from laminar flow into the turbulent flow regime. Viscous modifications are proposed for the k-omega model that yield close agreement with measurements and with Direct Numerical Simulation results for channel and pipe flow. These modifications permit prediction of subtle sublayer details such as maximum dissipation at the surface, k approximately y(exp 2) as y approaches 0, and the sharp peak value of k near the surface. With two transition specific closure coefficients, the model equations accurately predict transition for an incompressible flat-plate boundary layer. The analysis also shows why the k-epsilon model is so difficult to use for predicting transition.
Systèmes mécatroniques à paramètres variables : analyse du comportement et approche du tolérancement

Dans cette these nous avons propose une methode d’etude des variations parametriques pour les systemes mecatroniques continus et hybrides puis une approche du tolerancement mecatronique. Nous avons d’abord etudie les differentes approches existantes pour la prise en compte de la variation de parametres. Pour les systemes continus a parametres variables nous avons choisi la methode des inclusions differentielles. Nous avons repris l’algorithme de Raczynski et nous avons developpe un algorithme d’optimisation qui se base sur la methode du steepest descent, avec une extension permettant d’obtenir l’optimum global. Pour les systemes hybrides, contenant des evolutions continues et des sauts discrets, et qui presentent des variations parametriques, nous avons choisi le formalisme de l’inclusion differentielle impulsionnelle comme outil de modelisation. Nous avons repris ce formalisme et identifie ses elements sur un systeme mecatronique. Nous avons developpe des algorithmes de resolution des inclusions differentielles impulsionnelles pour un puis pour plusieurs parametres variables. Pour visualiser les resultats, les algorithmes developpes ont ete implementes sous Mathematica. Nous avons fini cette partie par une comparaison entre notre approche et d’autres comme celles autour des automates hybrides a invariant polyedre, les inclusions differentielles polygonales et l’algorithme pratique de resolution des inclusions differentielles. Nous avons montre alors certains avantages de notre approche. En derniere partie, nous avons repris les differents outils utilises et resultats obtenus pour definir et affiner notre approche du tolerancement. Nous avons defini la zone du fonctionnement desire, les differents cas de figures qu’elle peut presenter et son intersection avec le domaine atteignable. Nous avons presente un outil metrique base sur la distance topologique de Hausdorff pour le calcul des distances entre ces differents ensembles. Munis de ces elements, nous avons propose une demarche iterative pour le tolerancement dans l’espace d’etat.
The nature of voids – II. Tracing underdensities with biased galaxies

We study how the properties of cosmic voids depend on those of the tracer galaxy populations in which they are identified. We use a suite of halo occupation distribution (HOD) mocks in a simulation, identify voids in these populations using the ZOBOV void finder and measure their abundances, sizes, tracer densities, and dark matter content. To separate the effects of bias from those of sampling density, we do the same for voids traced by randomly down-sampled subsets of the simulation dark matter particles. At the same sampling density, galaxy bias reduces the total number of voids by ~50% and can dramatically change their size distribution. The matter content of voids in biased and unbiased tracers also differs. Deducing void properties from simulation therefore requires the use of realistic galaxy mocks. We discuss how the void observables can be related to their matter content. In particular we consider the compensation of the total mass deficit in voids and find that the distinction between over- and under-compensated voids is not a function of void size alone, as has previously been suggested. However, we find a simple linear relationship between the average density of tracers in the void and the total mass compensation on much larger scales. The existence of this linear relationship holds independent of the bias and sampling density of the tracers. This provides a universal tool to classify void environments and will be important for the use of voids in observational cosmology.
Integrated Metabolomics, Lipidomics, and Genomics Reveal the Presence of a New Biomarker, Butanediol Glucuronide, Associated with the Activation of Liver Ketogenesis and Lipid Oxidation by Tomato-Based Sofrito in Obese Rats

The increasing prevalence of obesity worldwide has promoted research on human metabolism and foods such as sofrito, a tomato and olive oil-based sauce from the Mediterranean diet, has shown beneficial effects on obesity and related complications. Sofrito has been associated with better cardiovascular health, metabolic syndrome, and anti-inflammatory effects. The aim of this study was to understand how sofrito intake could contribute to the control of energy metabolism in obese rats. For this purpose, integrative untargeted lipidomics, metabolomics, and targeted gene expression approaches were used in the liver and adipose tissue to identify metabolic changes and the mechanism of action promoted by sofrito intake. A new biomarker was identified in the liver, butanediol glucuronide, an indicator of ketogenic activation and lipid oxidation after the sofrito intervention. Gene expression analysis revealed an increase in the uptake and liver oxidation of lipids for energy production and ketogenesis activation as fuel for other tissues in sofrito-fed animals. Sofrito altered the lipidomic profile in the fat depots of obese rats. This multiomics study identifies a new biomarker linked to the beneficial actions of sofrito against obesity and provides further insight into the beneficial effect of the Mediterranean diet components.
MnASI1 Mediates Resistance to Botrytis cinerea in Mulberry (Morus notabilis)

Six α-amylase/subtilisin inhibitor genes (MnASIs) were identified from mulberry (Morus notabilis). In this study, bioinformatics and expression pattern analysis of six MnASIs were performed to determine their roles in resistance to B. cinerea. The expression of all six MnASIs was significantly increased under Botrytis cinerea infection. MnASI1, which responded strongly to B. cinerea, was overexpressed in Arabidopsis and mulberry. The resistance of Arabidopsis and mulberry overexpressing MnASI1 gene to B. cinerea was significantly improved, the catalase (CAT) activity was increased, and the malondialdehyde (MDA) content was decreased after inoculation with B. cinerea. At the same time, H2O2 and O2− levels were reduced in MnASI1 transgenic Arabidopsis, reducing the damage of ROS accumulation to plants. In addition, MnASI1 transgenic Arabidopsis increased the expression of the salicylic acid (SA) pathway-related gene AtPR1. This study provides an important reference for further revealing the function of α-amylase/subtilisin inhibitors.
Rebutting fake news on full spectral fitting

A recent paper by Ge et al. performs a series of experiments with two full spectral fitting codes, pPXF and starlight, finding that the two yield consistent results when the input spectrum is not heavily reddened. For E(B − V) & 0.2, however, they claim starlight leads to severe biases in the derived properties. Counterintuitively, and at odds with previous simulations, they find that this behaviour worsens significantly as the signal-to-noise ratio of the input spectrum increases. This communication shows that this is entirely due to an AV < 1 mag condition imposed while initializing the Markov chains in the code. This choice is normally irrelevant in real-life galaxy work but can become critical in artificial experiments. Alleviating this usually harmless initialization constraint changes the Ge et al. results completely, as was explained to the authors before their publication. We replicate their spectral fitting experiments, finding much smaller biases. Furthermore both bias and scatter in the derived properties all converge as S/N increases, as one would expect. We also show how the very output of the code provides ways of diagnosing anomalies in the fits. The code behaviour has been documented in careful and extensive experiments in the literature, but the biased analysis of Ge et al. is just not representative of starlight at all.
Analysis and testing of a new method for drop size measurement using laser scatter interferometry

Research was conducted on a laser light scatter detection method for measuring the size and velocity of spherical particles. The method is based upon the measurement of the interference fringe pattern produced by spheres passing through the intersection of two laser beams. A theoretical analysis of the method was carried out using the geometrical optics theory. Experimental verification of the theory was obtained by using monodisperse droplet streams. Several optical configurations were tested to identify all of the parametric effects upon the size measurements. Both off-axis forward and backscatter light detection were utilized. Simulated spray environments and fuel spray nozzles were used in the evaluation of the method. The measurements of the monodisperse drops showed complete agreement with the theoretical predictions. The method was demonstrated to be independent of the beam intensity and extinction resulting from the surrounding drops. Signal processing concepts were considered and a method was selected for development.
Postural Evaluation in Young Healthy Adults through a Digital and Reproducible Method

Different tools for the assessment of posture exist, from the simplest and cheap plumb line to complex, expensive, 3D-marker-based systems. The aim of this study is to present digital postural normative data of young adults collected through a mobile app to expand the possibilities of digital postural evaluation. A sample of 100 healthy volunteers, 50 males and 50 females, was analyzed with the mobile app Apecs-AI Posture Evaluation and Correction System® (Apecs). The Student’s t-test evaluated differences between gender to highlight if the digital posture evaluation may differ between groups. A significant difference was present in the anterior coronal plane for axillary alignment (p = 0.04), trunk inclination (p = 0.03), and knee alignment (p = 0.01). Head inclination (p = 0.04), tibia shift (p = 0.01), and foot angle (p < 0.001) presented significant differences in the sagittal plane, while there were no significant differences in the posterior coronal plane. The intraclass correlation coefficient (ICC) was considered to evaluate reproducibility. Thirteen parameters out of twenty-two provided an ICC > 0.90, three provided an ICC > 0.60, and six variables did not meet the cut-off criteria. The results highlight that digital posture analysis of healthy individuals may present slight differences related to gender. Additionally, the mobile app showed good reproducibility according to ICC. Digital postural assessment with Apecs could represent a quick method for preventing screening in the general population. Therefore, clinicians should consider this app’s worth as an auxiliary posture evaluation tool.
Planet seeding through gas-assisted capture of interstellar objects

Planet formation begins with collisional growth of small planetesimals accumulating into larger ones. Such growth occurs while planetesimals are embedded in a gaseous protoplanetary disc. However, small-planetesimals experience collisions and gas-drag that lead to their destruction on short timescales, not allowing, or requiring fine tuned conditions for the efficient growth of $\sim$ metre-size objects. Here we show that $\sim10^{4}$ interstellar objects such as the recently detected 1I/2017-U1 ('Oumuamua) could have been captured, and become part of the young Solar System, together with up to hundreds of $\sim$ km sized ones. The capture rates are robust even for conservative assumptions on the protoplanetary disc structure, local stellar environment and planetesimal ISM density. 'Seeding' of such planetesimals then catalyze further planetary growth into planetary embryos, and potentially alleviate the main-challenges with the meter-size growth-"barrier". The capture model is in synergy with the current leading planet formation theories, providing the missing link to the first planetesimals. Moreover, planetesimal capture provides a far more efficient route for lithopanspermia than previously thought.
In Vitro Characterization of a Tissue Renin-Angiotensin System in Human Nucleus Pulposus Cells

Low back pain is a clinically highly relevant musculoskeletal burden and is associated with inflammatory as well as degenerative processes of the intervertebral disc. However, the pathophysiology and cellular pathways contributing to this devastating condition are still poorly understood. Based on previous evidence, we hypothesize that tissue renin-angiotensin system (tRAS) components, including the SARS-CoV-2 entry receptor angiotensin-converting enzyme 2 (ACE2), are present in human nucleus pulposus (NP) cells and associated with inflammatory and degenerative processes. Experiments were performed with NP cells from four human donors. The existence of angiotensin II, angiotensin II type 1 receptor (AGTR1), AGTR2, MAS-receptor (MasR), and ACE2 in human NP cells was validated with immunofluorescent staining and gene expression analysis. Hereafter, the cell viability was assessed after adding agonists and antagonists of the target receptors as well as angiotensin II in different concentrations for up to 48 h of exposure. A TNF-α-induced inflammatory in vitro model was employed to assess the impact of angiotensin II addition and the stimulation or inhibition of the tRAS receptors on inflammation, tissue remodeling, expression of tRAS markers, and the release of nitric oxide (NO) into the medium. Furthermore, protein levels of IL-6, IL-8, IL-10, and intracellular as well as secreted angiotensin II were assessed after exposing the cells to the substances, and inducible nitric oxide synthase (iNOS) levels were evaluated by utilizing Western blot. The existence of tRAS receptors and angiotensin II were validated in human NP cells. The addition of angiotensin II only showed a mild impact on gene expression markers. However, there was a significant increase in NO secreted by the cells. The gene expression ratios of pro-inflammatory/anti-inflammatory cytokines IL-6/IL-10, IL-8/IL-10, and TNF-α/IL-10 were positively correlated with the AGTR1/AGTR2 and AGTR1/MAS1 ratios, respectively. The stimulation of the AGTR2 MAS-receptor and the inhibition of the AGTR1 receptor revealed beneficial effects on the gene expression of inflammatory and tissue remodeling markers. This finding was also present at the protein level. The current data showed that tRAS components are expressed in human NP cells and are associated with inflammatory and degenerative processes. Further characterization of the associated pathways is warranted. The findings indicate that tRAS modulation might be a novel therapeutic approach to intervertebral disc disease.
Assessment of regional development needs according to criteria based on the
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When a regional government considers investing funds for the sustainable development of its region, it must consider the real needs of the population and the fulfillment of the Sustainable Development Goals (SDGs). The identification of needs should be carried out with the support of local stakeholders representing various social groups. This paper seeks to answer the question of how to guide public investment policies at the local level, such as improving education, health, transportation and others, to better meet the SDGs. To answer this question, a multi-criteria decision-making process is followed, whereby, once the needs are classified by investment areas, they are prioritized based on criteria derived from the SDGs. The problem is complex because of the difficulty of the local stakeholder engagement process and also because of the interrelationships and influences that arise between all the elements of the decision problem: criteria and alternatives. To address this complexity, the Analytical Network Process method combined with DEMATEL will be followed. This process is applied to the case study of the distribution of funds allocated by the Government of Colombia to the Meta Region (Colombia) with the participation of 48 stakeholders to identify needs and the support of six experts in sustainability and project management for their prioritization
Formation rates and evolution histories of magnetars

We constrain the formation rate of Galactic magnetars directly from observations. Combining spin-down rates, magnetic activity, and association with supernova remnants, we put a 2$\sigma$ limit on their Galactic formation rate at $2.3-20\mbox{kyr}^{-1}$. This leads to a fraction $0. 4_{-0.28}^{+0.6}$ of neutron stars being born as magnetars. We study evolutionary channels that can account for this rate as well as for the periods, period derivatives and luminosities of the observed population. We find that their typical magnetic fields at birth are $3\times 10^{14}-10^{15}$G, and that those decay on a time-scale of $\sim 10^4$years, implying a maximal magnetar period of $P_{\rm max}\approx 13$s. A sizable fraction of the magnetars' energy is released in outbursts. Giant Flares with $E\geq 10^{46}$ erg are expected to occur in the Galaxy at a rate of $\sim 5\mbox{kyr}^{-1}$. Outside our Galaxy, such flares remain observable by {\it Swift} up to a distance of $\sim 100$~Mpc, implying a detection rate of $\sim 5\mbox{ yr}^{-1}$. The specific form of magnetic energy decay is shown to be strongly tied to the total number of observable magnetars in the Galaxy. A systematic survey searching for magnetars could determine the former and inform physical models of magnetic field decay.
Complex optical/UV and X-ray variability of the Seyfert 1 galaxy 1H 0419–577

We present detailed broadband UV/optical to X-ray spectral variability of the Seyfert 1 galaxy 1H 0419-577 using six XMM-Newton observations performed during 2002-2003. These observations covered a large amplitude variability event in which the soft X-ray (0.3-2 keV) count rate increased by a factor of ~4 in six months. The X-ray spectra during the variability are well described by a model consisting of a primary power law, blurred and distant reflection. The 2-10 keV power-law flux varied by a factor ~7 while the 0.3-2 keV soft X-ray excess flux derived from the blurred reflection component varied only by a factor of ~2. The variability event was also observed in the optical and UV bands but the variability amplitudes were only at the 6-10% level. The variations in the optical and UV bands appear to follow the variations in the X-ray band. During the rising phase, the optical bands appear to lag behind the UV band but during the declining phase, the optical bands appear to lead the UV band. Such behavior is not expected in the reprocessing models where the optical/UV emission is the result of reprocessing of X-ray emission in the accretion disc. The delayed contribution of the broad emission lines in the UV band or the changes in the accretion disc/corona geometry combined with X-ray reprocessing may give rise to the observed behavior of the variations.
The density of dark matter haloes of early-type galaxies in low-density environments

New photometric and long-slit spectroscopic observations are presented for NGC 7113, PGC 1852, and PGC 67207 which are three bright galaxies residing in low-density environments. The surface-brightness distribution is analysed from the K-S-band images taken with adaptive optics at the Gemini North Telescope and the ugriz-band images from the Sloan Digital Sky Survey while the line-of-sight stellar velocity distribution and line-strength Lick indices inside the effective radius are measured along several position angles. The age, metallicity, and aelement abundance of the galaxies are estimated from single stellar-population models. In spite of the available morphological classification, images show that PGC 1852 is a barred spiral which we do not further consider for mass modelling. The structural parameters of the two early-type galaxies NGC 7113 and PGC 67207 are obtained from a two-dimensional photometric decomposition and the mass-to-light ratio of all the (luminous and dark) mass that follows the light is derived from orbit-based axisymmetric dynamical modelling together with the mass density of the dark matter halo. The dynamically derived mass that follows the light is about a factor of 2 larger than the stellar mass derived using stellar-population models with Kroupa initial mass function. Both galaxies have a lower content of halo dark matter with respect to early-type galaxies in high-density environments and in agreement with the predictions of semi-analytical models of galaxy formation.
Definitions of vortex vector and vortex

Although the vortex is ubiquitous in nature, its definition is somewhat ambiguous in the field of fluid dynamics. In this absence of a rigorous mathematical definition, considerable confusion appears to exist in visualizing and understanding the coherent vortical structures in turbulence. Cited in the previous studies, a vortex cannot be fully described by vorticity, and vorticity should be further decomposed into a rotational and a non-rotational part to represent the rotation and the shear, respectively. In this paper, we introduce several new concepts, including local fluid rotation at a point and the direction of the local fluid rotation axis. The direction and the strength of local fluid rotation are examined by investigating the kinematics of the fluid element in two- and three-dimensional flows. A new vector quantity, which is called the vortex vector in this paper, is defined to describe the local fluid rotation and it is the rotational part of the vorticity. This can be understood as that the direction of the vortex vector is equivalent to the direction of the local fluid rotation axis, and the magnitude of vortex vector is the strength of the location fluid rotation. With these new revelations, a vortex is defined as a connected region where the vortex vector is not zero. In addition, through direct numerical simulation (DNS) and large eddy simulation (LES) examples, it is demonstrated that the newly defined vortex vector can fully describe the complex vertical structures of turbulence.