Miracle-dz/UniFAR-FTUs huggingface dataset:
Dynamic Role-based Access Control for Web Services using Context and Trust

Currently, the security issues of Web services are hot area in information system (IS). This research mainly discusses the key technologies of information access control focusing on following works: After analyzing the dynamic characteristic of application nature for Web services, a Dynamic Role-Based Access Control using Context and Trust model (abbreviated as CT-DRBAC) for Web services is proposed. During Web services, both the subject of invoking request and object of providing service resources are dynamic nature. So, access policies are needed to consider the dynamic nature. The proposed model has been developed and the authorization framework is discussed detail. In order to implement the dynamic trust management mechanism, a dynamic user role authorization algorithm which considers the user lifecycle contexts in the open systems is proposed and designed to meet the dynamic characteristic of subject and object effectively, and achieve intelligent and scientific user role assignments. The proposed access control module can be used in intelligent information systems to grant dynamically roles to users according to the current context.
Predicting dynamic signaling network response under unseen perturbations

MOTIVATION Predicting trajectories of signaling networks under complex perturbations is one of the most valuable, but challenging, tasks in systems biology. Signaling networks are involved in most of the biological pathways, and modeling their dynamics has wide applications including drug design and treatment outcome prediction. RESULTS In this paper, we report a novel model for predicting the cell type-specific time course response of signaling proteins under unseen perturbations. This algorithm achieved the top performance in the 2013 8th Dialogue for Reverse Engineering Assessments and Methods (DREAM 8) subchallenge: time course prediction in breast cancer cell lines. We formulate the trajectory prediction problem into a standard regularization problem; the solution becomes solving this discrete ill-posed problem. This algorithm includes three steps: denoising, estimating regression coefficients and modeling trajectories under unseen perturbations. We further validated the accuracy of this method against simulation and experimental data. Furthermore, this method reduces computational time by magnitudes compared to state-of-the-art methods, allowing genome-wide modeling of signaling pathways and time course trajectories to be carried out in a practical time. AVAILABILITY AND IMPLEMENTATION Source code is available at http://guanlab.ccmb. med.umich. edu/DREAM/code.html and as supplementary file online.
A quantitative measure of JS’s memory

JS is a highly able, well-educated 37 year old man with Asperger syndrome. A recent qualitative paper (Boucher, 2007) described his self-report of verbal and visual memory difficulties. The present paper used the WMS-III to compare the memory profile of JS to that of the adults with HFA in the Williams et al. (2005) WMS-III paper. Results show that JS’s self-report of his memory difficulties can by and large be supported, that JS’s memory performance is at the lower end of the group examined in the Williams et al. (2005) paper, and that, unlike the group profile in Williams et al. (2005), JS shows reduced performance on both verbal and visual measures of memory. A qualitative analysis of JS’s performance raises the possibility that JS is using language to retain details he can generalize over, as a compensatory strategy for some reductions in episodic memory.
APPROXIMATING CUMULATIVE BANDWIDTH REQUIREMENTS FOR THE DELIVERY OF STORED VIDEO

This paper introduces a movie approximation technique for the creation of bandwidth smoothing plans for the eff icient networking of stored digital video. Previous bandwidth smoothing algorithms require access to all the pre-stored information about a video stream (namely the frame sizes) in order to achieve their optimal properties. For future interactive systems over inter-networks, this requirement may prove to be too stringent, both in the computing power required to calculate bandwidth smoothing plans for simple set-topboxes and the abilit y to dynamically alter the video rate during congestion. The proposed approach allows for the creation of bandwidth smoothing plans that are less than 1% within optimal (in terms of peak bandwidth requirement, number of rate changes, and bandwidth variabilit y) and require significantly less computation.
Issues on Displaying 3 D Data for Scientific Visualization

Scienti c visualization often deals with three-dimensional data. Either the data is inherently three-dimensional, e.g., ow simulation data or medical data, or 3D is chosen as the biggest reasonable projection space for high-dimensional data, e.g., dynamical systems or databases. Since conventional displays usually are twodimensional, this data has to be transformed to two dimensions which leads to information loss. Objects in front occlude others lying behind them, lines appear to coalesce into a uni ed solid surface of indeterminate depth. This paper gives a short overview of some approaches which try to enhance the spatial impression of three-dimensional data displayed as two-dimensional pictures.
Evaluation of the Learning Classifier System XCS for SoC run-time control

In this paper, we evaluate the feasibility of using the learning classifier XCS to control a System-on-Chip. Increasing number of transistors and process variation make it difficult for a chip designer to foresee all possible run-time conditions. Postponing some decisions from design time to run time alleviates the designer’s life and allows shorter time-to-market. In this paper, we evaluate if XCS can take these runtime decisions on a processor with four cores. The evaluation shows that XCS can find optimal operating points, even in changed environments or with changed reward functions. This even works, though limited, without the genetic algorithm the XCS uses internally. The results motivate us to continue the evaluation for more complex setups.
Phase diagram of iron, revised‐core temperatures

Shock‐wave experiments on iron preheated to 1573 K from 14 to 73 GPa, yield sound velocities of the γ‐ and liquid‐phases. Melting is observed in the highest pressure (∼71 ± 2 GPa) experiments at calculated shock temperatures of 2775 ± 160 K. This single crossing of the γ‐liquid boundary agrees with the γ‐iron melting line of Boehler [1993] , Saxena et al. [1993] , and Jephcoat and Besedin [1997] . This γ‐iron melting curve is ∼300°C lower than that of Shen et al. [1998] at 80 GPa. In agreement with Brown [2001] the discrepancy between the diamond cell melting data and the iron shock temperatures require the occurrence of yet another sub‐solidus phase along the principal Hugoniot at ∼200 GPa. This would reconcile the static and dynamic data for iron's melting curve. Upward pressure and temperature extrapolation of the γ‐iron melting curve to 330 GPa yields 5300 ± 400 K for the inner core‐outer core boundary temperature.
Development of a 1-DOF wearable force feedback device with soft actuators and comparative evaluation of the actual objects and virtual objects in the AR space

A desktop force feedback device is able to render reaction force of virtual objects. However, the desktop type limits operator's motion. In contrast, a wearable force feedback device allows us to interact with virtual objects while moving in virtual space. In this study, we have developed a 1-DOF wearable force feedback device with MR brake and pneumatic artificial muscles. These actuators are lightweight, have a high power density, and are controlled by feed-forward control. This device is equipped with the operator's arm and renders various forces, such as friction, elasticity, and viscosity. In this paper, we improve the device to solve existing problems from previous studies. The proposed device is tested to confirm its basic properties. It is applied to augmented reality space and comparisons of subjective evaluations between virtual objects and actual objects
Unexpectedly broad target recognition of the CRISPR-mediated virus defence system in the archaeon Sulfolobus solfataricus

The hyperthermophilic archaeon Sulfolobus solfataricus carries an extensive array of clustered regularly interspaced short palindromic repeats (CRISPR) systems able to mediate DNA degradation of invading genetic elements when complementarity to the small CRISPR-derived (cr)RNAs is given. Studying virus defence in vivo with recombinant viral variants, we demonstrate here that an unexpectedly high number of mutations are tolerated between the CRISPR-derived guide RNAs (crRNAs) and their target sequences (protospacer). Up to 15 mismatches in the crRNA still led to ∼50% of DNA degradation, when these mutations were outside the ‘seed’ region. More than 15 mutations were necessary to fully abolished interference. Different from other CRISPR systems investigated in vivo, mutations outside the protospacer region indicated no need for a protospacer adjacent motif sequence to confer DNA interference. However, complementarity of only 3 nucleotides between the repeat-derived 5′ handle of the crRNA and nucleotides adjacent to the protospacer enabled self-recognition, i.e. protection of the host locus. Our findings show commonalities and differences among the various CRISPR-mediated defence systems and suggest that they should not merely be perceived as a ‘first-barrier-defence system’ but may be considered to have a broader mechanism that allows host cells to cope with viruses keeping them at reduced levels.
Effect of Cognitive Load on Distraction During Visual Search

Salient visual features have been known to capture attention, but there is disagreement regarding why these features capture attention (because of their bottom-up salience/uniqueness or the goals of the observer). To explore whether attention capture is truly a bottom-up, stimulus-driven, and automatic effect, Boot, Brockmole, & Simons (2005) added an auditory task to a traditional attention capture paradigm. In single task conditions, they found that onsets (objects that appear suddenly) and color singletons (items of a unique color compared to the items around them) captured attention. However, when participants also had to listen to the auditory task, the degree to which these distractors captured attention changed (onsets capture was eliminated while color singleton capture increased). These findings challenge the notion that capture is stimulus-driven and automatic; the search display was exactly the same in single and dual-task situations. However, it was puzzling why onsets decreased in their ability to capture attention while color singletons increased under the same dual-task conditions. Boot, Brockmole, & Simons (2005) proposed a transience hypothesis: transient singletons like an onset require cognitive resources to be recognized as being unique, while sustained distractors such as color-singletons required cognitive resources to suppress. We tested this hypothesis with onset distractors that were either the same as the other distractors in the display, or onset distractors that also had a unique shape. Contrary to predictions, neither had the ability to capture attention under dual-task load. Results do not support stimulus-driven accounts of attention capture. Theoretical and practical significance is discussed.
A Meta-Analysis of Nonpharmacological Interventions for People With Parkinson’s Disease

Nonpharmacological interventions are important in providing care for Parkinson’s disease (PD) patients. However, there is limited evidence related to their impacts on health-related quality of life (HRQOL). We aimed to examine the effectiveness of nonpharmacological interventions for improving the HRQOL of PD patients. Articles published in peer-reviewed journals from 2000 to 2015 were searched through electronic searching, computerized author searching, and footnote chasing. A meta-analysis was performed using the RevMan 5.3 program. Overall, effect size for the studies (n = 18) was −4.17 with 95% confidence interval (CI) from −7.63 to −0.70 (Z = 2.36, p = .02), indicating positive effects of nonpharmacological interventions on HRQOL. In subgroup analysis regarding the intervention types, the effect size of exercise programs was −5.73 with 95% CI of −11.36 to −0.10 (Z = 2.00, p = .05). Thus, nonpharmacological interventions, and particularly exercise programs, were effective in improving the HRQOL of PD patients.
Pemetrexed in combination with cisplatin versus cisplatin monotherapy in patients with recurrent or metastatic head and neck cancer

Recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN) is associated with poor survival. Platinum‐based chemotherapy is often a first‐line treatment. Pemetrexed has shown single‐agent activity in SCCHN and in combination with cisplatin for other tumors. This trial examined the efficacy of pemetrexed‐cisplatin for SCCHN.
Craving e prontidão para mudança em mulheres adultas jovens dependentes do tabaco

The objective of this research was to analyze tobacco craving in young adult females in order to verify if there is any association between this and the stages of change. The design was experimental, and the participants, 20 to 40 year-olds, were distributed at random, in zero (n = 30) to 60 minutes (n = 30) of tobacco abstinence groups. The Instruments used were: Social and Demographic Data Form, Questionnaire of Smoking Urges Brief (QSU-B), Fagerstrom Test for Nicotine Dependence and University of Rhode Island Change Assessment Scale. It has been observed the following correlations (p < 0,005): Pre-Contemplation and total score at QSU-B (r = 0,465); Pre-Contemplation and Factor 2 (r = 0,485); and Maintenance and Factor 2 (r = 0,385). It has been concluded that, while females in Pre-Contemplation showed craving global increase, strongly influenced by tobacco negative reinforcement, the ones in the Maintenance stage had only an increasing craving associated to negative reinforcement. This information is very useful to select the treatment to such patients.
Pharmacology of the Spinal Action of Ketorolac, Morphine, ST-91, U50488H, and L-PIA on the Formalin Test and an Isobolographic Analysis of the NSAID Interaction

Background:Noxious cutaneous stimuli enhance spinal excitability. The behavioral correlate to this response is found in the rat formalin test, in which formalin injection into the hindpaw evokes signs of nociception (flinching and licking of the injected paw) with acute (phase 1) and delayed-hyperalgesic (phase 2) components. Methods:The effect of intrathecal morphine (a µ agonist), U50488H (a κ agonist), ST-91 (an α2 agonist), L-PIA (an adenosine A1 agonist), and ketorolac (a nonsteroidal antiinflammatory drug, or NSAID), were examined in rats undergoing the formalin test. Spinal interactions between ketorolac and the µ, κ, α2, and adenosine A1 agonists were assessed using isobolographic analysis. Results:Morphine and ST-91 caused a dose-dependent suppression of phase 1 and phase 2 of the formalin test, while U50488H and L-PIA had little effect on phase 1, but caused dose-dependent depression of phase 2. Intrathecal ketorolac inhibited the phase 2 response, but had limited effect on phase 1. The isobolographic analysis revealed a significant synergy (with fractional dose ratios of less than 1) between ketorolac and morphine or ST-91 for phase 1 and phase 2, but only an additive interaction was found between ketorolac and L-PIA or U50488H. Conclusions:These observations offer systematic support for the powerful interaction between NSAIDs and opioids and certain other analgesics in clinical pain states. These studies also demonstrate that spinal synergy is not a common property of all interactions. Thus, the NSAID synergy appears to occur with agents that exert a concurrent action both preand postsynaptic to the primary afferents.
Intestinal Parasitosis, Haemoglobin and Eosinophil Levels of Patients Attending University of Calabar Teaching Hospital, Calabar, Nigeria

Aims: To determine the effect of intestinal parasites on the haemoglobin concentration and eosinophil levels among the patients treated at the University of Calabar Teaching Hospital (UCTH), Nigeria. Study Design: This was cross sectional study. Ethical approval and patients’ informed consent were sought and obtained before collection and processing of samples. Place and Duration of Study: Outpatient clinic, UCTH, Calabar between July, 2013 and May, 2014. Methodology: We included 300 patients (114 males, 186 females). Intestinal parasites were detected by direct stool microscopy and formol ether concentration technique. Haemoglobin (Hb) concentration was determined by Cyanmethaemoglobin method while eosinophil levels were determined by differential eosinophil count. Original Research Article Otu-Bassey et al.; IBRR, 7(2): 1-8, 2017; Article no.IBRR. 31861 2 Results: Overall, 30% of the studied subjects were positive for intestinal parasites, 23% had low Hb concentration (below 110.0 g/L) while 27% had high eosinophil count (≥ 7%). Parasite positive subjects had lower Hb concentration and higher eosinophil levels compared to their parasite negative counterpart (56.7% versus 8.6%) and (70% versus 8.6%), respectively (P< 0.001). Multiple infections was more related to Hb reduction and high eosinophil levels than single infections (80% versus 45%) and (90% versus 60%), respectively (P< 0.001). Hook worm showed the highest occurrence (26.7%) followed by Ascaris lumbricoides 23.3%, Trichuris trichiura 10%, and Entamoeba histolytica 6.7%. In single infections, Hook worm infected subjects recorded more reduction in Hb and increased eosinophil count (99.0 g/L and 15%, respectively) while in multiple infections, hookworm/Entamoeba histolytica co-infected subjects took the lead (70.0 g/L and 19%, respectively). There was no association between intestinal parasites prevalence by gender of subjects (P = 0.2128). Conclusions: Intestinal parasitosis may result in anaemia and eosinophilia and the decrease in haemoglobin concentration and increase in eosinophil count is directly related to the degree of parasitosis. It is recommended that stool microscopy, haemoglobin estimation and eosinophil counts be routinely performed for all patients visiting the hospital.
Plasma glucose levels and white blood cell count are related with ankle brachial index in type 2 diabetic subjects.

INTRODUCTION Type 2 diabetes mellitus (T2DM) is a major risk factor for peripheral arterial disease (PAD). A simple, noninvasive method for the estimation of PAD is ankle brachial index (ABI). The aim of the present study was to determine whether there is an association between ABI and cardiovascular risk factors in T2DM subjects without apparent macrovascular disease. METHODS A total of 125 T2DM subjects (84 males, 41 females, mean age ± standard deviation 62.2 ± 9.1 years) who had no apparent macrovascular disease and who attended the Health Center of Erymantheia between January 2008 and June 2009 were recruited to the study. RESULTS Of the study subjects 20% (n=25) had ABI <0.90. Univariate linear regression analysis showed that ABI was significantly associated with history of hypertension (p=0.02), fasting serum glucose levels (p=0.02), serum urea levels (p=0.005), serum uric acid levels (p=0.007) and white blood cell (WBC) count (p=0.04). Multivariate linear regression analysis demonstrated significant independent associations between ABI and fasting serum glucose levels (p=0.03) as well as WBC count (p=0.03). CONCLUSIONS Elevated plasma glucose and WBC count increase the risk of PAD in asymptomatic diabetics.
Persistent Local Pain After Posterior Spine Surgery for Thoracic Lesions

Many surgeons have investigated local pain associated with posterior spine surgery for cervical or lumbar lesions. However, little information is available concerning local pain after posterior thoracic spine surgery. This prospective study was, thus, performed to investigate the frequency and clinical features of local pain after posterior spine surgery for thoracic lesions. In 29 consecutive patients undergoing posterior spine surgery for various thoracic spinal disorders, local pain was investigated before and after surgery. In all 19 patients with preoperative back pain presumably due to thoracic lesions, pain was well alleviated after surgery. In contrast, 6 patients (21%) newly developed persistent shoulder angle pain after surgery, which resembled axial pain after cervical laminoplasty. In 5 of these 6 patients surgical exposure was extended to the cervicothoracic junction, whereas persistent shoulder angle pain was independent of disease etiologies and surgical procedure, and all of the 5 patients had no other etiologies of local pain such as surgical site infections, hardware failures, pseudoarthrosis, other metastasis, and vertebral fractures. These results suggest that dissection of muscle attachments to the cervicothoracic junction would play some part in the development of persistent local pain after posterior spine surgery for thoracic lesions, although surgical exposure of the zygapophysial joints at the cervicothoracic junction might be a possible source of postoperative shoulder pain. Therefore, to minimize such surgical complications, muscle insertions into the cervicothoracic junction should be preserved as far as possible.
MENTAL HEALTH AS A PREDICTOR OF EMOTIONAL COMPETENCE OF PROSPECTIVE TEACHERS OF SCIENCE IN HIMACHAL PRADESH

This paper reports on mental health as a predictor of emotional competence of prospective teachers of science. The present investigation is descriptive in nature. The study was carried on 120 prospective teachers of science from four districts of Himachal Pradesh. The investigator used Scale of Emotional Competence (SEC) developed by Sharma and Bhardwaj (1998) to measure emotional competence while Mental Health Inventory developed by Jagdish and Srivastava (1996) was used to study the mental health of prospective teachers of science. The findings of the study revealed that prospective teachers of science belonging to general and reserved categories were significantly different in their emotional competence. No significant difference was found in the emotional competence of high and low mentally healthy prospective teachers of science. The study also reported that no significant interactional effects were found between the variables. The researchers have suggested the means to improve the mental health and emotional competence of the prospective teachers of science.