Miracle-dz/UniFAR-FTUs huggingface dataset:
Building vectorization inside a favela utilizing lidar spot elevation

This article reveals the understanding of informal settlements in Brazil as much as it details the approximate population, the genesis and major impacts on Brazilian society. It also reports, the difficulties faced by local authorities in maintaining cohesive, extensive and above all updated record. Especially taking into account that approximately 17.5% of the population occupies improper locations, according to the formal planning. Because, they are not included in the records dedicated to the territorial organization of the city hall and have more pronounced population density than in cities with urban design. Bringing consequences that exacerbate inequality and the process of social exclusion. In addition, it highlights features of the Airborne Laser Scanner, sensor responsible for laser profiling. Activity contracted by the Municipality of Belo Horizonte, from 2008 coupled with aerophotogrammetric survey that brought a number of advantages including the DEM across the county extension. The study describes a methodology which by treating the laser profiling data with embedded routines in Matlab platform allows the roof eaves registry of buildings in Cluster Cafezal. The author mentions that the strategy when added to the relational database can help to develop an incipient registration.
The risk of developing major depression among individuals with subthreshold depression: a systematic review and meta-analysis of longitudinal cohort studies

Abstract Background Studies have consistently shown that subthreshold depression is associated with an increased risk of developing major depression. However, no study has yet calculated a pooled estimate that quantifies the magnitude of this risk across multiple studies. Methods We conducted a systematic review to identify longitudinal cohort studies containing data on the association between subthreshold depression and future major depression. A baseline meta-analysis was conducted using the inverse variance heterogeneity method to calculate the incidence rate ratio (IRR) of major depression among people with subthreshold depression relative to non-depressed controls. Subgroup analyses were conducted to investigate whether IRR estimates differed between studies categorised by age group or sample type. Sensitivity analyses were also conducted to test the robustness of baseline results to several sources of study heterogeneity, such as the case definition for subthreshold depression. Results Data from 16 studies (n = 67 318) revealed that people with subthreshold depression had an increased risk of developing major depression (IRR = 1.95, 95% confidence interval 1.28–2.97). Subgroup analyses estimated similar IRRs for different age groups (youth, adults and the elderly) and sample types (community-based and primary care). Sensitivity analyses demonstrated that baseline results were robust to different sources of study heterogeneity. Conclusion The results of this study support the scaling up of effective indicated prevention interventions for people with subthreshold depression, regardless of age group or setting.
A 340/380 nm light‐emitting diode illuminator for Fura‐2 AM ratiometric Ca2+ imaging of live cells with better than 5 nM precision

We report the first demonstration of a fast wavelength-switchable 340/380 nm light emitting diode (LED) illuminator for Fura-2 ratiometric Ca2+ imaging of live cells. The LEDs closely match the excitation peaks of bound and free Fura-2 and enables the precise detection of cytosolic Ca2+ concentrations, which is only limited by the Ca2+ response of Fura-2. Using this illuminator, we have shown that Fura-2 acetoxymethyl ester (AM) concentrations as low as 250 nM can be used to detect induced Ca2+ events in tsA-201 cells and while utilizing the 150 μs switching speeds available, it was possible to image spontaneous Ca2+ transients in hippocampal neurons at a rate of 24.39 Hz that were blunted or absent at typical 0.5 Hz acquisition rates. Overall, the sensitivity and acquisition speeds available using this LED illuminator significantly improves the temporal resolution that can be obtained in comparison to current systems and supports optical imaging of fast Ca2+ events using Fura-2.
Poster: EasyDefense: Towards Easy and Effective Protection Against Malware for Smartphones

As the dominant mobile operating system in the markets of smartphones, Android platform is increasingly targeted by attackers. Besides, attackers often produce novel malware to bypass the conventional detection approaches, which are largely reliant on expert analysis to design the discriminative features manually. Therefore, more effective and easy-to-use approaches for detection of Android malware are in demand. In this paper, we design and implement EasyDefense, a lightweight defense system that is integrated with Android OS for easy and effective detection of Android malware utilizing machine learning methods and the ensemble of them. Besides universal static features such as permissions and API calls, EasyDefense also employs the N-gram features of operation codes (opcodes). These N-gram features are extracted and learnt automatically from raw data of applications. Experimental results on 204,650 applications show that users can easily and effectively protect the privacy and security on their smartphones through this system.
Resolving Structure and Mechanical Properties at the Nanoscale of Viruses with Frequency Modulation Atomic Force Microscopy

Structural Biology (SB) techniques are particularly successful in solving virus structures. Taking advantage of the symmetries, a heavy averaging on the data of a large number of specimens, results in an accurate determination of the structure of the sample. However, these techniques do not provide true single molecule information of viruses in physiological conditions. To answer many fundamental questions about the quickly expanding physical virology it is important to develop techniques with the capability to reach nanometer scale resolution on both structure and physical properties of individual molecules in physiological conditions. Atomic force microscopy (AFM) fulfills these requirements providing images of individual virus particles under physiological conditions, along with the characterization of a variety of properties including local adhesion and elasticity. Using conventional AFM modes is easy to obtain molecular resolved images on flat samples, such as the purple membrane, or large viruses as the Giant Mimivirus. On the contrary, small virus particles (25–50 nm) cannot be easily imaged. In this work we present Frequency Modulation atomic force microscopy (FM-AFM) working in physiological conditions as an accurate and powerful technique to study virus particles. Our interpretation of the so called “dissipation channel” in terms of mechanical properties allows us to provide maps where the local stiffness of the virus particles are resolved with nanometer resolution. FM-AFM can be considered as a non invasive technique since, as we demonstrate in our experiments, we are able to sense forces down to 20 pN. The methodology reported here is of general interest since it can be applied to a large number of biological samples. In particular, the importance of mechanical interactions is a hot topic in different aspects of biotechnology ranging from protein folding to stem cells differentiation where conventional AFM modes are already being used.
Parental influences on children’s food behaviours: challenges and opportunities from studying culturally diverse samples

The article ‘Somali, Latino and Hmong parents’ perceptions and approaches about raising healthy weight children: a community-based participatory research study’ by Arcan et al., published in this journal, presents perceptions of parents from specific cultural groups regarding their children’s weight, food behaviour and physical activity. It also introduces a number of interesting points worth exploring.
Different Pattern of Chronic Obstructive Pulmonary Disease Assessment Test Score between Chronic Bronchitis and Non-chronic Bronchitis Patients

Background Chronic bronchitis (CB) is an important phenotype in chronic obstructive pulmonary disease (COPD). The purpose of this study is to evaluate different pattern of COPD assessment test (CAT) score between CB and non-CB patients. Methods Patients were recruited from 45 centers in Korea, as part of the Korean COPD Subgroup Study cohort. CB was defined when sputum continued for at least 3 months. Results Total 958 patients with COPD were eligible for analysis. Among enrolled patients, 328 (34.2%) were compatible with CB. The CAT score was significantly higher in patients with CB than non-CB, and each component of CAT score showed a similar result. CB was significantly associated with CAT score when adjusted with age, sex, modified Medical Research Council, and post-bronchodilator forced expiratory volume in 1 second. Each component of CAT score between patients with CB and non-CB showed different pattern according to Global Initiative for Chronic Obstructive Lung Disease grade. Conclusion CAT score is significantly higher in patients with CB than non-CB. Each component of CAT score was significantly different between two groups.
FGFR作为肺鳞癌潜在治疗靶点的研究进展

肺鳞状细胞癌（squamous-cell lung cancer, SqCLC）是非小细胞肺癌中一类独特的病理类型，患者多为高龄、发病隐匿、发现时常属晚期、常伴有心肺合并症、缺乏有效的靶向治疗药物等因素，相对于非鳞非小细胞肺癌，SqCLC的治疗面临着更大的挑战。 近年针对肺癌的分子靶向药物迅速发展，我们发现，FGFR家族（FGFR1-4）基因改变存在于约12%的SqCLC中，是SqCLC中突变频率最高的酪氨酸激酶家族基因，同时许多靶向FGFR的小分子药物都在各类肿瘤中发挥了较好的治疗效果。 目前，许多FGFR抑制治疗SqCLC的临床试验也都正在进行当中，可能为SqCLC治疗提供新的策略和方向。
The Ubiquity of Intraguild Predation among Predatory Arthropods

Intraguild predation (IGP) occurs when one predator species attacks another predator species with which it competes for a shared prey species. Despite the apparent omnipresence of intraguild interactions in natural and managed ecosystems, very few studies have quantified rates of IGP in various taxa under field conditions. We used molecular analyses of gut contents to assess the nature and incidence of IGP among four species of coccinellid predators in soybean fields. Over half of the 368 predator individuals collected in soybean contained the DNA of other coccinellid species indicating that IGP was very common at our field site. Furthermore, 13.2% of the sampled individuals contained two and even three other coccinellid species in their gut. The interaction was reciprocal, as each of the four coccinellid species has the capacity to feed on the others. To our knowledge, this study represents the most convincing field evidence of a high prevalence of IGP among predatory arthropods. The finding has important implications for conservation biology and biological control.
When is more frequent hemodialysis beneficial?

The use of frequent hemodialysis (HD) is growing, with the hope of improving outcomes in end‐stage renal disease. We narratively review the three randomized trials, 15 comparative cohort studies, and several case series of frequent HD that empirically demonstrate the potential efficacy and adverse effects of these regimens. Taken together, the randomized studies suggest frequent HD may result in left ventricular mass regression. This effect is most pronounced when left ventricular mass is abnormal, but attenuated by significant residual urine output. Both frequent short and long HD consistently improved blood pressure control and reduced antihypertensive use, despite greater weekly interdialytic weight gains. Serum phosphate was lowered. Frequent short daytime HD improved health‐related quality of life, while frequent long overnight HD did not. Regarding adverse effects, frequent HD patients underwent significantly more procedures to salvage arteriovenous vascular accesses. An absolute increase in hypotensive episodes was observed with frequent short HD, while frequent long HD accelerated residual renal function loss and increased perceived caregiver burden. The effect of frequent HD on mortality is controversial, due to conflicting results and limitations of published studies. Finally, pregnancy outcomes may be substantially better with frequent long HD. On the basis of these data, we suggest frequent HD is most likely to benefit patients with left ventricular hypertrophy particularly if there is minimal urine output, those unable to attain dry weight on a thrice weekly schedule, and pregnant women. All patients receiving frequent HD should be advised of and monitored for potential risks.
Is maternal education level associated with diet in 10-year-old children?

Abstract Objective To examine the associations between maternal education level and diet in 10-year-old children. Design Three-day diet diaries (child completed with parental help) were collected. Height and weight were measured in research clinics. Maternal education level was derived from a questionnaire completed during pregnancy and classified into low, medium or high. One-way ANOVA was undertaken to compare maternal education groups for nutrient intakes and the Kruskal–Wallis test used for food consumption. Setting Avon Longitudinal Study of Parents and Children (ALSPAC), Bristol, UK. Subjects Children (n 7474) who provided dietary data at age 10 years. Results A large proportion (60 %) of the sample was classified as plausible reporters, with under-reporting accounting for 36 %. No clear differences were found for intakes of energy or macronutrients between maternal education groups for plausible reporters. However, there were marked differences in micronutrient intakes especially for vitamin C, retinol equivalents and folate, highlighting lower diet quality with lower maternal education level. Intakes of fruit and vegetables showed a positive gradient with increasing maternal education (57 % v. 79 % consumed fresh fruit in low and high educational groups, respectively). A trend towards higher intake in the lower educated group was shown for less healthy foods (meat pies P < 0·001; sausages, burgers and kebabs P < 0·001). Conclusions The quality of children's diet at 10 years was related to maternal education level. Lower maternal education was associated with less healthy food choices that could be detrimental to health. Further research is needed to establish if these associations can be explained by other socio-economic factors.
Toward standardized mapping for left atrial analysis and cardiac ablation guidance

In catheter-based cardiac ablation, the pulmonary vein ostia are important landmarks for guiding the ablation procedure, and for this reason, have been the focus of many studies quantifying their size, structure, and variability. Analysis of pulmonary vein structure, however, has been limited by the lack of a standardized reference space for population based studies. Standardized maps are important tools for characterizing anatomic variability across subjects with the goal of separating normal inter-subject variability from abnormal variability associated with disease. In this work, we describe a novel technique for computing flat maps of left atrial anatomy in a standardized space. A flat map of left atrial anatomy is created by casting a single ray through the volume and systematically rotating the camera viewpoint to obtain the entire field of view. The technique is validated by assessing preservation of relative surface areas and distances between the original 3D geometry and the flat map geometry. The proposed methodology is demonstrated on 10 subjects which are subsequently combined to form a probabilistic map of anatomic location for each of the pulmonary vein ostia and the boundary of the left atrial appendage. The probabilistic map demonstrates that the location of the inferior ostia have higher variability than the superior ostia and the variability of the left atrial appendage is similar to the superior pulmonary veins. This technique could also have potential application in mapping electrophysiology data, radio-frequency ablation burns, or treatment planning in cardiac ablation therapy.
Therapeutic Potential of Invariant Natural Killer T Cells in Autoimmunity

Tolerance against self-antigens is regulated by a variety of cell types with immunoregulatory properties, such as CD1d-restricted invariant natural killer T (iNKT) cells. In many experimental models of autoimmunity, iNKT cells promote self-tolerance and protect against autoimmunity. These findings are supported by studies with patients suffering from autoimmune diseases. Based on these studies, the therapeutic potential of iNKT cells in autoimmunity has been explored. Many of these studies have been performed with the potent iNKT cell agonist KRN7000 or its structural variants. These findings have generated promising results in several autoimmune diseases, although mechanisms by which iNKT cells modulate autoimmunity remain incompletely understood. Here, we will review these preclinical studies and discuss the prospects for translating their findings to patients suffering from autoimmune diseases.
2.65 GHz 340 W dual internally matched FETs for compact doherty power amplifiers

This paper presents dual IMFETs for a compact DPA based on pre-matching networks and GaN-HEMT bare-dies. For impedance matching networks from very low optimum load and source impedances of the high-power transistor bare-die, input and output pre-matching networks using MOS capacitors and multiple bond-wires are employed for two high-power GaN-HEMT bare-dies, which are used for the carrier and peaking amplifiers of the compact DPA. Additional matching networks on small substrates are implemented for the matched source and load impedances of 50 since the optimum input impedance and the complex conjugate of the optimum load impedance can be used to partially match the pre-matching networks. At the same time, the second harmonic impedances are terminated to the optimal regions using the sufficiently large capacitances of the MOS capacitors and bond-wire inductances of the input and output pre-matching networks. The dual IMFETs have a total size of 23 × 35 mm2. The DPA module was implemented by adding an input splitter and Doherty load network to the dual IMFETs. The DPA exhibited a drain efficiency of 44% at an average output power of 49.8 dBm, using a down-link LTE signal having a center frequency of 2.65 GHz, a channel bandwidth of 10 MHz, and a PAPR of 6.5 dB.
Prion Type-Dependent Deposition of PRNP Allelic Products in Heterozygous Sheep

ABSTRACT Susceptibility or resistance to prion infection in humans and animals depends on single prion protein (PrP) amino acid substitutions in the host, but the agent's modulating role has not been well investigated. Compared to disease incubation times in wild-type homozygous ARQ/ARQ (where each triplet represents the amino acids at codons 136, 154, and 171, respectively) sheep, scrapie susceptibility is reduced to near resistance in ARR/ARR animals while it is strongly enhanced in VRQ/VRQ carriers. Heterozygous ARR/VRQ animals exhibit delayed incubation periods. In bovine spongiform encephalopathy (BSE) infection, the polymorphism effect is quite different although the ARR allotype remains the least susceptible. In this study, PrP allotype composition in protease-resistant prion protein (PrPres) from brain of heterozygous ARR/VRQ scrapie-infected sheep was compared with that of BSE-infected sheep with a similar genotype. A triplex Western blotting technique was used to estimate the two allotype PrP fractions in PrPres material from BSE-infected ARR/VRQ sheep. PrPres in BSE contained equimolar amounts of VRQ- and ARR-PrP, which contrasts with the excess (>95%) VRQ-PrP fraction found in PrP in scrapie. This is evidence that transmissible spongiform encephalopathy (TSE) agent properties alone, perhaps structural aspects of prions (such as PrP amino acid sequence variants and PrP conformational state), determine the polymorphic dependence of the PrPres accumulation process in prion formation as well as the disease-associated phenotypic expressions in the host. IMPORTANCE Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative and transmissible diseases caused by prions. Amino acid sequence variants of the prion protein (PrP) determine transmissibility in the hosts, as has been shown for classical scrapie in sheep. Each individual produces a separate PrP molecule from its two PrP gene copies. Heterozygous scrapie-infected sheep that produce two PrP variants associated with opposite scrapie susceptibilities (136V-PrP variant, high; 171R-PrP variant, very low) contain in their prion material over 95% of the 136V PrP variant. However, when these sheep are infected with prions from cattle (bovine spongiform encephalopathy [BSE]), both PrP variants occur in equal ratios. This shows that the infecting prion type determines the accumulating PrP variant ratio in the heterozygous host. While the host's PrP is considered a determining factor, these results emphasize that prion structure plays a role during host infection and that PrP variant involvement in prions of heterozygous carriers is a critical field for understanding prion formation.
Measuring Quality of Services (QoS) of several forwarding strategies on Named Data Networking(NDN) using ndnSIM

The growth of internet has shown the limitation TCP/IP architecture and has enforced the practitioners to invent a new architecture that are more capable to support large scale implementation of content based distribution. Today, Named Data Networking (NDN) has become a breakthrough alternative solution and a potential choice for next generation internet architecture. In this paper, we perform investigation to which extend existing forwarding strategies capable to support context information networking and increase service quality. We test this scenario to handle various types of user applications such as VoIP, multimedia streaming, and widely used application data delivery protocols, with specific requests (contexts), then find out which parts of the app prerequisites are consistent with the current strategy. We used NS3 with ndnSIM 2.0 to simulate and evaluate. This research mainly focused on the implementation of HTTP protocol alongside with the NDN. The experiment results show that Stochastic Adaptive Forwarding strategy provides excellent performance in different experiment scenarios.