Miracle-dz/UniFAR-FTUs huggingface dataset:
SKIN+: Fabricating Soft Fluidic User Interfaces for Enhancing On-Skin Experiences and Interactions

Human skin is the largest organ on our body not only senses and external environment. A growing number of researchers devote themselves to design seamless interfaces directly on skin. In this late-breaking work, we propose a novel way for creating dynamic 2.5D skin textures, called SKIN+, a soft fluidic mini-scale user interface by introducing fluidic actuation. We have created four swatches with different pre-defined textures, topologies and structures to explore how this fluidic actuation system can benefit on-skin experiences and interactions. Our work details the intriguing experiences and interactions and future applications of on-skin wearables. Our work also extends the expressiveness, aesthetics and design space of soft fluidic interface as skin decoration and beauty technology.
Deep Semantic Face Deblurring Supplementary Material

In this supplementary document, we present additional results to complement the paper. First, we provide the network parameters and configuration of our face parsing network, face deblurring network and discriminator for the adversarial training. Second, we present additional analysis on the multi-scale deblurring network, perceptual loss and adversarial loss. Finally, we show more qualitative comparisons with state-of-the-art algorithms on both synthetic datasets and real blurred face images.
Host and symbiont genetic contributions to fitness in a Trichogramma–Wolbachia symbiosis

The fitness effects associated with Wolbachia infection have wide-ranging ecological and evolutionary consequences for host species. How these effects are modulated by the relative influence of host and Wolbachia genomes has been described as a balancing act of genomic cooperation and conflict. For vertically transmitted symbionts, like cytoplasmic Wolbachia, concordant host–symbiont fitness interests would seem to select for genomic cooperation. However, Wolbachia’s ability to manipulate host reproductive systems and distort offspring sex ratios presents an evolutionary conflict of interest with infected hosts. In the parthenogenesis-inducing (PI) form of Wolbachia found in many haplodiploid insects, Wolbachia fitness is realized through females and is enhanced by their feminization of male embryos and subsequent parthenogenetic reproduction. In contrast, as long as Wolbachia is not fixed in a population and sexual reproduction persists, fitness for the host species is realized through both male and female offspring production. How these cooperating and competing interests interact and the relative influence of host and Wolbachia genomes were investigated in the egg parasitoid Trichogramma kaykai, where Wolbachia infection has remained at a low frequency in the field. A factorial design in which laboratory cultures of Wolbachia-infected T. kaykai were cured and re-infected with alternative Wolbachia strains was used to determine the relative influence of host and Wolbachia genomes on host fitness values. Our results suggest fitness variation is largely a function of host genetic background, except in the case of offspring sex ratio where a significant interaction between host and Wolbachia genomes was found. We also find a significant effect associated with the horizontal transfer of Wolbachia strains, which we discuss in terms of the potential for coadaptation in PI-Wolbachia symbioses.
HPV Infection: Immunological Aspects and Their Utility in Future Therapy

High prevalence and mortality rates of cervical cancer create an imperative need to clarify the uniqueness of HPV (Human Papillomavirus) infection, which serves as the key causative factor in cervical malignancies. Understanding the immunological details and the microenvironment of the infection can be a useful tool for the development of novel therapeutic interventions. Chronic infection and progression to carcinogenesis are sustained by immortalization potential of HPV, evasion techniques, and alterations in the microenvironment of the lesion. Inside the lesion, Toll-like receptors expression becomes irregular; Langerhans cells fail to present the antigens efficiently, tumor-associated macrophages aggregate resulting in an unsuccessful immune response by the host. HPV products also downregulate the expression of microenvironment components which are necessary for natural-killer cells response and antigen presentation to cytotoxic cells. Additionally HPV promotes T-helper cell 2 (Th2) and T-regulatory cell phenotypes and reduces Th1 phenotype, leading to suppression of cellular immunity and lesion progression to cancer. Humoral response after natural infection is inefficient, and neutralizing antibodies are not adequate in many women. Utilizing this knowledge, new endeavors, such as therapeutic vaccination, aim to stimulate cellular immune response against the virus and alter the milieu of the lesion.
Estrogen trial for patients with endometrial cancer.

TO RESOLVE the question of whether estrogen replacement therapy (ERT) is safe even for women who have had earlystage endometrial cancer, a multicenter randomized trial will begin enrolling patients this summer. The Gynecologic Oncology Group of the American College of Obstetricians and Gynecologists (ACOG), Washington, DC, hopes to enroll at least 2000 women in the National Cancer Institute (NCI)—sponsored ERT Study, said principal investigator Richard Barakat, MD. Speaking at ACOG's 45th annual meeting in Las Vegas, Nev, Barakat, who is an attending physician at Memorial Sloan-Kettering Cancer Center, New York, NY, called on all ACOG members and other physicians to help recruit for this study. In the past, ERT has not been recommended for postmenopausal women with a history of uterine cancer because of concern that the estrogen might increase the risk of recurrence, said Robert C. Park, MD, chair of the Gynecologic Oncology Group. "We now have no evidence
Co-designing Mobile Online Safety Applications with Children

Parents use mobile monitoring software to observe and restrict their children's activities in order to minimize the risks associated with Internet-enabled mobile devices. As children are stakeholders in such technologies, recent research has called for their inclusion in its design process. To investigate children's perceptions of parental mobile monitoring technologies and explore their interaction preferences, we held two co-design sessions with 12 children ages 7-12. Children first reviewed and redesigned an existing mobile monitoring application. Next, they designed ways children could use monitoring software when they encounter mobile risks (e.g., cyberbullying, inappropriate content). Results showed that children acknowledged safety needs and accepted certain parental controls. They preferred and designed controls that emphasized restriction over monitoring, taught risk coping, promoted parent-child communication, and automated interactions. Our results benefit designers looking to develop parental mobile monitoring technologies in ways that children will both accept and can actively benefit from.
The Impact of Short-Term Stochastic Variability in Solar Irradiance on Optimal Microgrid Design

This paper proposes a new methodology to capture the impact of fast moving clouds on utility power demand charges observed in microgrids with photovoltaic (PV) arrays, generators, and electrochemical energy storage. It consists of a statistical approach to introduce sub-hourly events in the hourly economic accounting process. The methodology is implemented in the distributed energy resources customer adoption model (DER-CAM), a state of the art mixed integer linear model used to optimally size DER in decentralized energy systems. Results suggest that previous iterations of DER-CAM could undersize battery capacities. The improved model depicts more accurately the economic value of PV as well as the synergistic benefits of pairing PV with storage.
MirrorMirror: A Mobile Application to Improve Speechreading Acquisition

Many people around the world have difficulties in day-to-day conversation due to hearing loss. Hearing aids often fail to offer enough benefits and have low adoption rates. However, people with hearing loss find that speechreading can improve their understanding during conversation, but speechreading is a challenging skill to learn. Speechreading classes can improve acquisition, however there are a limited number of classes available and students can only practice effectively when attending class. To address this, we conducted a postal survey with 59 speechreading students to understand students' perspectives on practicing. Using our findings, we developed an Android application called MirrorMirror - a new Speechreading Acquisition Tool (SAT) that allows students to practice their speechreading by recording and watching videos of people they frequently speak with. We evaluated MirrorMirror through three case studies with speechreading students and found that they could effectively target their speechreading practice on people, words and situations they encounter during daily conversations.
Diabetic macular oedema: under‐represented in the genetic analysis of diabetic retinopathy

Diabetic retinopathy, a complication of both type 1 and type 2 diabetes, is a complex disease and is one of the leading causes of blindness in adults worldwide. It can be divided into distinct subclasses, one of which is diabetic macular oedema. Diabetic macular oedema can occur at any time in diabetic retinopathy and is the most common cause of vision loss in patients with type 2 diabetes. The purpose of this review is to summarize the large number of genetic association studies that have been performed in cohorts of patients with type 2 diabetes and published in English‐language journals up to February 2017. Many of these studies have produced positive associations with gene polymorphisms and diabetic retinopathy. However, this review highlights that within this large body of work, studies specifically addressing a genetic association with diabetic macular oedema, although present, are vastly under‐represented. We also highlight that many of the studies have small patient numbers and that meta‐analyses often inappropriately combine patient data sets. We conclude that there will continue to be conflicting results and no meaningful findings will be achieved if the historical approach of combining all diabetic retinopathy disease states within patient cohorts continues in future studies. This review also identifies several genes that would be interesting to analyse in large, well‐defined cohorts of patients with diabetic macular oedema in future candidate gene association studies.
Factorising folds for faster functions

Abstract The worker/wrapper transformation is a general technique for improving the performance of recursive programs by changing their types. The previous formalisation (A. Gill & G. Hutton, J. Funct. Program., vol. 19, 2009, pp. 227–251) was based upon a simple fixed-point semantics of recursion. In this paper, we develop a more structured approach, based upon initial-algebra semantics. In particular, we show how the worker/wrapper transformation can be applied to programs defined using the structured pattern of recursion captured by fold operators, and illustrate our new technique with a number of examples.
Sensitivity Jump of Micro Accelerometer Induced by Micro-fabrication Defects of Micro Folded Beams

Abstract The abnormal phenomenon occurring in sensor calibration is an obstacle to product development but a useful guideline to product improvement. The sensitivity jump of micro accelerometers in the calibrating process is recognized as an important abnormal behavior and investigated in this paper. The characteristics of jumping output in the centrifuge test are theoretically and experimentally analyzed and their underlying mechanism is found to be related to the varied stiffness of supporting beam induced by the convex defect on it. The convex defect is normally formed by the lithography deviation and/or etching error and can result in a jumping stiffness of folded microbeams and further influence the sensitivity when a part of the bending beams is stopped from moving by two surfaces contacting. The jumping level depends on the location of convex and has nothing to do with the contacting properties of beam and defects. Then the location of defect is predicted by theoretical model and simulation and verified by the observation of micro structures under microscopy. The results indicate that the tested micro accelerometer has its defect on the beam with a distance of about 290μm from the border of proof mass block.
Should FEV1/FEV6 replace FEV1/FVC ratio to detect airway obstruction? A metaanalysis.

BACKGROUND The conventional FEV(1)/FVC test is the "gold standard" to quantitate airway obstruction, but elderly subjects or patients with severe respiratory diseases quite frequently cannot make such an effort. Many studies have investigated the usefulness of FEV(1)/forced expired volume in 6 s (FEV(6)) measurements as an alternative for FEV(1)/FVC for diagnosis of airway obstruction. We conducted a meta-analysis to determine the FEV(1)/FEV(6) substitute for FEV(1)/FVC in the diagnosis of airway obstruction. METHODS After a systematic review of all-language studies, sensitivity, specificity, and other measures of accuracy of FEV(1)/FEV(6) in the diagnosis of airway obstruction were pooled using random-effects models. Summary receiver operating characteristic curves were used to summarize overall test performance. RESULTS Eleven studies met our inclusion criteria. The summary estimates for FEV(1)/FEV(6) in the diagnosis of airway obstruction in the studies included were as follows: sensitivity, 0.89 (95% confidence interval [CI], 0.83 to 0.93); specificity, 0.98 (95% CI, 0.95 to 0.99); positive likelihood ratio, 45.46 (95% CI, 18.26 to 113.21); negative likelihood ratio, 0.11 (95% CI, 0.08 to 0.17); diagnostic odds ratio, 396.02 (95% CI, 167.32 to 937.31); and diagnostic score, 5.98 (95% CI, 5.12 to 6.84). CONCLUSIONS FEV(1)/FEV(6) is a sensitive and specific test for the diagnosis of airway obstruction. FEV(1)/FEV(6) can be used as a valid alternative for FEV(1)/FVC in the diagnosis of airway obstruction.
Leveraging Friendship Networks for Dynamic Link Prediction in Social Interaction Networks

On-line social networks (OSNs) often contain many different types of relationships between users. When studying the structure of OSNs such as Facebook, two of the most commonly studied networks are friendship and interaction networks. The link prediction problem in friendship networks has been heavily studied. There has also been prior work on link prediction in interaction networks,independent of friendship networks. In this paper, we study the predictive power of combining friendship and interaction networks. We hypothesize that, by leveraging friendship networks, we can improve the accuracy of link prediction in interaction networks. We augment several interaction link prediction algorithms to incorporate friendships and predicted friendships. From experiments on Facebook data, we find that incorporating friendships into interaction link prediction algorithms results in higher accuracy, but incorporating predicted friendships does not when compared to incorporating current friendships.
Button++: Designing Risk-aware Smart Buttons

Buttons are the most commonly used input devices. So far the goal of the designers was to provide a passive button that can accept user input as easily as possible. Therefore, based on Fitts' law, they maximize the size of the button and make the distance closer. This paper proposes Button++, a novel method to design smart buttons that actively judge user's movement risk and selectively trigger input. Based on the latest model of moving target selection, Button++ tracks the user's submovement just before the click and infers the expected error rate that can occur if the user repeatedly clicks with the same movement. This allows designers to make buttons that actively respond to the amount of risk in the user's input movement.
Cytological diagnosis of follicular dendritic cell sarcoma: A case report and review of literature

Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm of the accessory immune cells that can present at both nodal and extranodal sites1 . A high index of suspicion is crucial so as to include FDCS in the differential diagnosis of a spindle cell neoplasm in the appropriate clinical and morphological context. However, the morphological overlap with other tumors makes this entity a diagnostic challenge unless supplemented by other ancillary tests like immunohistochemistry and ultrastructural studies. This article is protected by copyright. All rights reserved.
Orexin/Hypocretin: A Neuropeptide at the Interface of Sleep, Energy Homeostasis, and Reward System

Recent studies have implicated the orexin system as a critical regulator of sleep/wake states as well as feeding behavior and reward processes. Orexin deficiency results in narcolepsy in humans, dogs, and rodents, suggesting that the orexin system is particularly important for maintenance of wakefulness. In addition, orexin deficiency also cause abnormalities in energy homeostasis and reward systems. Orexin activates waking active monoaminergic and cholinergic neurons in the hypothalamus and brainstem regions to maintain a long, consolidated waking period. Orexin neurons receive abundant input from the limbic system. Orexin neurons also have reciprocal links with the hypothalamic arcuate nucleus, which regulates feeding. Moreover, the responsiveness of orexin neurons to peripheral metabolic cues, such as leptin and glucose, suggest that these neurons have important role as a link between the energy homeostasis and vigilance states. Orexin neurons also have a link with the dopaminergic reward system in the ventral tegmental nucleus. These findings suggest that the orexin system interacts with systems that regulate emotion, reward, and energy homeostasis to maintain proper vigilance states. Therefore, this system may be a potentially important therapeutic target for treatment of sleep disorder, obesity, emotional stress, and addiction.
Phenotypic alterations of regulatory T cells in autoimmune hepatitis: Causal or associated with treatment and remission?

for disease progression in chronic viral hepatitis. However, this is in contrast with the findings of Kuniholm et al. In a recent study from our group, HCV patients with cirrhosis, as assessed by transient elastography, had higher levels of sCD163 and sCD206 (the shed mannose receptor), compared to those with no/mild fibrosis. However, sCD206 was inferior to sCD163 in cirrhosis prediction, supporting the notion that sCD163 may be the best macrophagespecific biomarker in chronic viral hepatitis. In our published report, liver biopsy data were available for all patients and we focused on the relationship between sCD163 and the histological scores for inflammation and fibrosis. For this reason, the associations between sCD163 and APRI/FIB-4 were omitted, but we are pleased to present them here. Consistent with the data by Kuniholm et al., sCD163 (logarithmically transformed) was strongly associated with APRI (r 5 0.64; P< 0.001) and FIB-4 (r 5 0.59; P< 0.001) in our 551 HCV patients. In the 203 HBV patients, sCD163 was associated with APRI (r 5 0.51; P< 0.001) and showed a trend toward association with FIB-4 (r 5 0.14; P 5 0.09). To investigate the adjusted relationship between sCD163 and fibrosis, we performed multiple ordered logistic regression analysis with the fibrosis score as the dependent variable and sCD163, APRI, and FIB-4 (all logarithmically transformed) as the explanatory. In this model, we observed a clear significant association between sCD163 and the fibrosis score after adjustment for APRI and FIB-4, both in patients with HCV and HBV infection (Table 1). Taken together, the data indicate that sCD163 correlates with APRI and FIB-4, but possesses the capability for fibrosis prediction beyond both models, and this is further illustrated by the very good performance of sCD163-based fibrosis scores, particularly in HCV patients. Finally, we entirely agree with Kuniholm et al. that longitudinal studies of sCD163 and other macrophage markers, preferably under antiviral treatment with repeated liver biopsies, are needed to further elucidate the role of macrophages and the prognostic value of macrophage markers in chronic viral hepatitis. KONSTANTIN KAZANKOV, M.D. HOLGER JON MØLLER, M.D., PH.D., D.Sc. BO MARTIN BIBBY, M.Sc., PH.D. HENDRIK VILSTRUP, M.D., D.Sc., FRCP, FEBGH JACOB GEORGE, MBBS, Ph.D., FRACP HENNING GRØNBÆK, M.D., PH.D. Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus, Denmark Department of Clinical Biochemistry Aarhus University Hospital Aarhus, Denmark Department of Biostatistics Aarhus University Aarhus, Denmark The Storr Liver Unit University of Sydney and Westmead Hospital Westmead, Australia
Valorisation des boues papetières et du peuplier hybride dans la fabrication de panneaux de fibres de moyenne densité (MDF)

The wood composites industry has more and more di culties to nd raw materials. The aim of this project is to show that hybrid poplar and paper mill sludge are both sustainable ber ressources. Thirty medium-density berboard panels (MDF) were produced with 12% of ureaformaldehyde resin and various ratios of hybrid poplar bers and primary paper mill sludge from kraft and thermomechanical processes. According to the ASTM D-1037 standard method, the evaluated properties were modulus of elasticity, modulus of rupture, internal bond strength, thickness swell and linear expansion. Panel density and formaldehyde emission were also measured. The results show that MDF made from hybrid poplar fully satis es the industrial quality requirements. Panels with 25% of kraft or thermomechanical sludge meet the ANSI A208.2-2002 MDF standard for the highest grade. Overall, kraft sludge give inferior performances than thermomechanical sludge, probably due to their high ash content. For the lowest grade of ANSI A208.2-2002 MDF standard, it is possible to increase the amount of thermomechanical sludge to 75%. Sludge plays a signi cant role in MDF panel properties, particularly for internal bond strength, linear expansion and formaldehyde emission. In the future, research e orts should demonstrate that formaldehyde-free composites are compatible with paper mill sludge.