Miracle-dz/UniFAR-FTUs huggingface dataset:
PERANCANGAN APLIKASI BMI CALCULATOR UNTUK MEMPREDIKSI TINGKAT OBESITAS PADA MAHASISWA DENGAN METODE K-NEAREST NEIGHBOR

Obesitas menjadi salah satu permasalah kesehatan global yang dapat terjadi baik di negara berkembang maupun negara maju. Berdasarkan data Riskesdas, prevalensi penderita overweight dan obesitas pada orang dewasa (>18 tahun) menunjukkan peningkatan dari tahun 2013-2018. Obesitas dapat dipengaruhi oleh asupan energi yang berlebih, pola makan tidak sehat, dan kurangnya aktivitas fisik. Oleh karena itu diperlukan adanya pengetahuan dan pencegahan terutama pada mahasiswa agar senantiasa menjaga kesehatan tubuh. Pada penelitian ini menerapkan metode yang terdiri dari 6 tahap, yaitu menetapkan metode, melakukan studi pendahuluan, merumuskan masalah, mengumpulkan data (sumber data yang digunakan pada penulisan jurnal ini diperoleh dari kaggle.com dengan judul dataset Health Habits of Student, mengolah data (dengan Ms. Excel dan aplikasi Orange), dan kesimpulan. Tampilan user interface aplikasi mobile untuk pola hidup sehat dengan judul “BMI Calculator” khususnya pada tampilan infografis dan insight. Desain yang dirancang menggunakan aplikasi figma ini menampilkan rancangan infografis dan insight aplikasi BMI Calculator. Apabila aplikasi ini bisa diimplementasikan maka peneliti berharap dapat membantu masyarakat dalam pemantauan BMInya, sehingga dapat mengurangi persentase obesitas di Indonesia khususnya untuk kalangan mahasiswa.
Improvements in Maturity and Stability of 3D iPSC-Derived Hepatocyte-like Cell Cultures

Induced pluripotent stem cell (iPSC) technology enables differentiation of human hepatocytes or hepatocyte-like cells (iPSC-HLCs). Advances in 3D culturing platforms enable the development of more in vivo-like liver models that recapitulate the complex liver architecture and functionality better than traditional 2D monocultures. Moreover, within the liver, non-parenchymal cells (NPCs) are critically involved in the regulation and maintenance of hepatocyte metabolic function. Thus, models combining 3D culture and co-culturing of various cell types potentially create more functional in vitro liver models than 2D monocultures. Here, we report the establishment of 3D cultures of iPSC-HLCs alone and in co-culture with human umbilical vein endothelial cells (HUVECs) and adipose tissue-derived mesenchymal stem/stromal cells (hASCs). The 3D cultures were performed as spheroids or on microfluidic chips utilizing various biomaterials. Our results show that both 3D spheroid and on-chip culture enhance the expression of mature liver marker genes and proteins compared to 2D. Among the spheroid models, we saw the best functionality in iPSC-HLC monoculture spheroids. On the contrary, in the chip system, the multilineage model outperformed the monoculture chip model. Additionally, the optical projection tomography (OPT) and electrical impedance tomography (EIT) system revealed changes in spheroid size and electrical conductivity during spheroid culture, suggesting changes in cell–cell connections. Altogether, the present study demonstrates that iPSC-HLCs can successfully be cultured in 3D as spheroids and on microfluidic chips, and co-culturing iPSC-HLCs with NPCs enhances their functionality. These 3D in vitro liver systems are promising human-derived platforms usable in various liver-related studies, specifically when using patient-specific iPSCs.
The systematic and random variation of recorded radiance in a LANDSAT Thematic Mapper Image

Abstract In this study, we examine the systematic and random variations in recorded radiance in two of the LANDSAT Thematic Mapper bandpasses for images obtained over a uniform agricultural area before and after harvest. Large variations will affect the accuracy with which conclusions may be reached regarding ground cover from an analysis of recorded multiband radiance data. We found the variations to be sufficiently large to suggest a need for caution in the quantitative analysis of multichannel digital radiance data to discriminate terrestrial cover types.
A statistical comparison of wind speed, wave height, and wave period derived from satellite altimeters and ocean buoys in the Gulf of Mexico region

The capability of spaceborne altimeters to provide precise measurement of significant wave height and wind speed has been demonstrated repeatedly. It is shown in this paper that in addition to the significant wave height and wind speed, the wave period can be calculated from the semiempirical functions established from earlier wave research. The calculated characteristic wave period using the altimeter-derived wind speed and wave height are found to be in excellent agreement with the peak wave period and average wave period from the ocean buoy measurements in the Gulf of Mexico. Also, with the long time series of collocated data set, it is possible to compare altimeter output of wind and wave parameters with ocean buoy measurements taking into consideration the spatial lags between the buoy locations and the altimeter footprints, and the temporal lags between the two sensor systems. It is found that when the spatial lags are less than 10 km, the RMS difference of the significant wave height is approximately 0.1 m, which is the digitization resolution of the output from both altimeter and ocean buoy. For the wind speed, the RMS difference approaches 1.2 m/s in the Gulf of Mexico using the empirical algorithms. The wind speed agreement is significantly improved to 0.8 m/s when the tilting effect on the altimeter cross section is accounted for. In contrast to the spatial lags, temporal lags of up to 1 hour do not appear to produce significant difference in the statistics of comparison based on this study.
Impacts of Skin Color and Hypoxemia on Noninvasive Assessment of Peripheral Blood Oxygen Saturation: A Scoping Review

Standard pulse oximeters estimate arterial blood saturation (SaO2) non-invasively by emitting and detecting light of a specific wavelength through a cutaneous vascular bed, such as a digit or the ear lobe. The quantity measured at these peripheral sites is designated as oxygen saturation (SpO2). Most reliable pulse oximeters are calibrated from measurements of healthy volunteers using some form of oxygen desaturation method. As the degree of inducible hypoxemia is limited, the calibration below achievable desaturation levels is usually extrapolated, leading to potential measurement error at low SaO2 values, especially in highly pigmented skin. Such skin color-related errors (SCRE) are the topic of this scoping review. Specifically, this study aimed to identify the combined impact of skin color and reduced SaO2 on the non-invasive assessment of SpO2 and report the consequences of potential inaccuracies. Three databases were searched (Cumulated Index to Nursing and Allied Health Literature (CINAHL), PubMed, and Web of Science) for peer-reviewed prospective and retrospective studies published in English between 2000 and 2022 involving human patients with hypoxemia that included a measure of skin color (Fitzpatrick scale or race/ethnicity). Ten studies met the criteria and were included in the final review. Eight of these studies reported statistically significant higher pulse oximeter readings in darker-skinned patients with hypoxia compared to their arterial blood gas measurements. Occult hypoxia was more prevalent in Black and Hispanic patients than in White patients. Minority patients overall (Black, Asian, and American Indian) were more likely to have a SaO2 < 88% that was not detected by pulse oximetry (occult hypoxemia) during hospitalization. With greater levels of hypoxemia, the differences between SpO2 and SaO2 were greater. If SaO2 was < 90%, then SpO2 was overestimated in all ethnicities but worse in minorities. In conclusion, the bias found in pulse oximeter readings in the skin of color broadly impacts patients with hypoxemia. The failure of SpO2 measuring devices to detect occult hypoxemia can delay the delivery of life-saving treatment to critically ill patients requiring respiratory rehabilitation and supplemental oxygen therapy. This may lead to adverse health outcomes, increased in-hospital mortality, and complications such as organ dysfunction. An improvement in pulse oximeter detection mechanisms that would include all skin pigmentations is therefore much desired to optimize individual healthcare status and minimize disparities in treatment.
Use of Revised Universal Soil Loss Equation (RUSLE) and Historical Imagery for Claims of Sedimentation of Lakes and Streams

The consequences of erosion and subsequent sedimentation of lakes and streams are many and widespread. The natural process of erosion can be accelerated by land cover changes with an increase in areas of impervious surfaces. Sediment is continually being transported along all streams in nature and can come from anywhere in the watershed. Lakes slow the rate of velocity of the water and allow the entrained sediment to settle and accumulate. When sediment impacts water impoundments, legal actions may result. Even with evidence of specific sediment release, the forensic analysis may not be an open-and-shut case. The author presents a method to investigate the validity of a legal claim of a sediment-impacted lake at the outfall of a mixed rural/urban watershed. By combining land use change, soils, elevation and precipitation data, a maximum possible annual sediment loss was approximately 154 tonne per hectare (15.4 kg/m2). Lacking evidence of specific historic events of erosion and subsequent sedimentation, this method provides an equitable means of determining compensatory damages. Using aerial and satellite imagery provided historical evidence of land cover change and examples of significant erosion in the watershed and not named in the lawsuit. The focus of the litigation started with the property adjoining the effected lake. The analysis provides a method to investigate erosion and subsequent sedimentation claims at a watershed-scale.
Feeding Strategy to Use Beef Tallow and Modify Farmed Tiger Puffer Fatty Acid Composition

Simple Summary The supply of fish oil, which provides long-chain polyunsaturated fatty acids (LC-PUFA) but is mostly wild-caught, is stagnating, resulting in limited availability and high prices. Therefore, many alternative lipid sources, mainly vegetable oils and rendered animal fats, are increasingly being applied in fish feeds. However, these lipid sources do not contain LC-PUFA, and therefore lower the fillet quality in terms of the LC-PUFA content. Feeding strategies such as alternate feeding between fish oil- and alternative oils-based diets have been applied to maintain the n-3 LC-PUFA contents in farmed fish. The present study validated the relevant efficacy. Abstract A 12-week feeding experiment was conducted to evaluate the effects of replacing fish oil (FO) with beef tallow (BT) on the fatty acid composition of farmed tiger puffer (Takifugu rubripes). Two replacement strategies were used: a standard Graded Dietary Replacement of FO with BT (GDR strategy) and Alternate Feeding between FO- and BT-based Diets (AFD strategy). The positive and negative control diets were formulated with 6% FO (FO-C group) or BT (BT-C group) as the sole added lipid source. In the GDR strategy, three experimental diets were formulated, with 25, 50 and 75% of the added FO in the FO-C diet replaced with BT, named 25BT, 50BT and 75BT, respectively. In the AFD strategy, alternated feeding patterns between the FO-C and BT-C diet—namely, 1, 2 and 3 weeks with BT-C followed by 1 week feeding with FO-C (1BT-1FO, 2BT-1FO and 3BT-1FO, respectively)—were applied. Each diet or feeding strategy was assigned to triplicate tanks. The results showed that dietary BT inclusion reduced the contents of long-chain polyunsaturated fatty acids (LC-PUFA) in both the muscle and liver (edible tissues for this species) of the experimental fish, and the liver displayed a more drastic decrease than the muscle. The LC-PUFA content linearly decreased with the decreasing dietary FO levels in the GDR strategy. However, in the AFD strategy, a linear relationship was not observed between the LC-PUFA content and the FO feeding duration. The 3BT-1FO treatment resulted in higher LC-PUFA content than 2BT-1FO. When comparing the two strategies with the same final FO administration level—namely, 50BT vs. 1BT-1FO, and in particular, 75BT vs. 3BT-1FO—the AFD strategy resulted in higher LC-PUFA contents in both the muscle and liver than the GDR strategy. In conclusion, when FO was replaced with BT in the diets, alternate feeding between FO- and BT-based diets resulted in a higher LC-PUFA content than the standard direct replacement. Three weeks of feeding with BT-C followed by one week of feeding with FO-C appeared to be a good alternate feeding pattern. This study provided a promising strategy of FO-sparing in fish farming when the LC-PUFA contents were maintained as high as possible.
Dose distribution prediction for head-and-neck cancer radiotherapy using a generative adversarial network: influence of input data

Purpose A three-dimensional deep generative adversarial network (GAN) was used to predict dose distributions for locally advanced head and neck cancer radiotherapy. Given the labor- and time-intensive nature of manual planning target volume (PTV) and organ-at-risk (OAR) segmentation, we investigated whether dose distributions could be predicted without the need for fully segmented datasets. Materials and methods GANs were trained/validated/tested using 320/30/35 previously segmented CT datasets and treatment plans. The following input combinations were used to train and test the models: CT-scan only (C); CT+PTVboost/elective (CP); CT+PTVs+OARs+body structure (CPOB); PTVs+OARs+body structure (POB); PTVs+body structure (PB). Mean absolute errors (MAEs) for the predicted dose distribution and mean doses to individual OARs (individual salivary glands, individual swallowing structures) were analyzed. Results For the five models listed, MAEs were 7.3 Gy, 3.5 Gy, 3.4 Gy, 3.4 Gy, and 3.5 Gy, respectively, without significant differences among CP-CPOB, CP-POB, CP-PB, among CPOB-POB. Dose volume histograms showed that all four models that included PTV contours predicted dose distributions that had a high level of agreement with clinical treatment plans. The best model CPOB and the worst model PB (except model C) predicted mean dose to within ±3 Gy of the clinical dose, for 82.6%/88.6%/82.9% and 71.4%/67.1%/72.2% of all OARs, parotid glands (PG), and submandibular glands (SMG), respectively. The R2 values (0.17/0.96/0.97/0.95/0.95) of OAR mean doses for each model also indicated that except for model C, the predictions correlated highly with the clinical dose distributions. Interestingly model C could reasonably predict the dose in eight patients, but on average, it performed inadequately. Conclusion We demonstrated the influence of the CT scan, and PTV and OAR contours on dose prediction. Model CP was not statistically different from model CPOB and represents the minimum data statistically required to adequately predict the clinical dose distribution in a group of patients.
Generation of a human iPSC-derived cardiomyocyte/fibroblast engineered heart tissue model

Animal models have proven integral to broadening our understanding of complex cardiac diseases but have been hampered by significant species-dependent differences in cellular physiology. Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have shown great promise in the modelling of cardiac diseases despite limitations in functional and structural maturity. 3D stem cell-derived cardiac models represent a step towards mimicking the intricate microenvironment present in the heart as an in vitro model. Incorporation of non-myocyte cell types, such as cardiac fibroblasts, into engineered heart tissue models (EHTs) can help better recapitulate the cell-to-cell and cell-to-matrix interactions present in the human myocardium. Integration of human-induced pluripotent stem cell-derived cardiac fibroblasts (hiPSC-CFs) and hiPSC-CM into EHT models enables the generation of a genetically homogeneous modelling system capable of exploring the abstruse structural and electrophysiological interplay present in cardiac pathophysiology. Furthermore, the construction of more physiologically relevant 3D cardiac models offers great potential in the replacement of animals in heart disease research. Here we describe efficient and reproducible protocols for the differentiation of hiPSC-CMs and hiPSC-CFs and their subsequent assimilation into EHTs. The resultant EHT consists of longitudinally arranged iPSC-CMs, incorporated alongside hiPSC-CFs. EHTs with both hiPSC-CMs and hiPSC-CFs exhibit slower beating frequencies and enhanced contractile force compared to those composed of hiPSC-CMs alone. The modified protocol may help better characterise the interplay between different cell types in the myocardium and their contribution to structural remodelling and cardiac fibrosis.
Performance of R-438A in R-22 refrigeration and air conditioning systems.

With the accelerated phase out of R-22 underway, equipment owners and service contractors must develop a plan for operating, retrofitting, or replacing their existing R-22 refrigeration and air conditioning systems. In many cases, retrofitting the existing R-22 equipment to an alternative refrigerant is a viable, cost effective option for the equipment owner. R-438A is a non-ozone-depleting hydrofluorocarbon (HFC) refrigerant blend which can be used to retrofit existing hydrochlorofluorocarbon (HCFC) refrigerant R-22 refrigeration and air conditioning systems with direct expansion evaporators and positive displacement compressors. In most systems, the existing mineral oil (MO) or alkylbenzene (AB) lubricant can be used, reducing the cost and time required for the retrofit by eliminating the need to change to a polyolester (POE) lubricant. This paper will review the performance characteristics and oil return properties of R-438A from both laboratory tests and actual R-22 system retrofits. Topics to be covered in this presentation include refrigerant physical and environmental properties, material compatibility information, oil return properties, and capacity, energy efficiency, and operating data from both compressor calorimeter tests and actual R-22 refrigeration and air conditioning system retrofits.
Long-term mortality after transcatheter aortic valve implantation for aortic stenosis in immunosuppression-treated patients: a propensity-matched multicentre retrospective registry-based analysis

Introduction Data regarding patients with a previous medical record of immunosuppression treatment who have undergone transcatheter aortic valve implantation (TAVI) are limited and extremely inconclusive. Available studies are mostly short term observations; thus there is a lack of evidence on efficacy and safety of TAVI in this specific group of patients. Aim To compare the in-hospital and long-term outcomes between patients with or without a medical history of immunosuppressive treatment undergoing TAVI for aortic valve stenosis (AS). Material and methods We conducted a retrospective registry-based analysis including patients undergoing TAVI for AS at 5 centres between January 2009 and August 2017. The primary endpoint was long-term all-cause mortality. Secondary endpoints comprised major vascular complications, life-threatening or disabling bleeding, stroke and new pacemaker implantation. Results Of 1451 consecutive patients who underwent TAVI, two propensity-matched groups including 25 patients with a history of immunosuppression and 75 patients without it were analysed. No differences between groups in all-cause mortality were found in a median follow-up time of 2.7 years following TAVI (p = 0.465; HR = 0.73; 95% CI: 0.30–1.77). The rate of major vascular complications (4.0% vs. 5.3%) was similar in the two groups (p = 1.000). There were no statistically significant differences in the composite endpoint combining life-threatening or disabling bleeding, major vascular complications, stroke and new pacemaker implantation (40.0% vs. 20.0%, p = 0.218). Conclusions Patients who had undergone TAVI for AS had similar long-term mortality regardless of whether they had a previous medical record of immunosuppression. Procedural complication rates were comparable between the groups.
Spatial Patterns in Surface Energy Balance Components Derived from Remotely Sensed Data

A relatively simple modeling approach for estimating spatially distributed surface energy fluxes was applied to two small watersheds, one in a semi-arid climate region and one in a sub-humid region. This approach utilized a combination of ground-based meteorological data and remotely sensed data to estimate ‘instantaneous’ surface energy fluxes at the time of the satellite or aircraft overpasses. The spatial resolution in the watershed grid cells, which was on the order of 100-400 km, was selected to be compatible with ground measurements used for validation. The model estimates of surface energy fluxes compared well with ground-based measurements of surface flux (typically within approximately 40 Wm−2). The model accuracy may be slightly less for bare soil surfaces due to an overestimation of the soil heat flux. In addition to demonstrating the feasibility of computing spatially distributed values of surface energy fluxes, these maps were used to qualitatively infer the dominant factors controlling the energy fluxes for the time period shortly following precipitation events in the basins. For the semi-arid watershed, values of sensible heat flux varied considerably over the watershed and displayed a pattern very similar to that of the spatially variable cumulative precipitation for at least one to eight days prior to the image acquisition. Due to the large fraction of exposed bare soil in a semi-arid ecosystem, even very small precipitation events had a strong influence on the pattern of sensible heat fluxes observed shortly after the event (less than 24 hours). For the sub-humid watershed, the fluxes tended to be more uniform across the watershed, and were influenced by a combination of precipitation total and land cover type.
Combination of Phenethyl Isothiocyanate and Dasatinib Inhibits Hepatocellular Carcinoma Metastatic Potential through FAK/STAT3/Cadherin Signalling and Reduction of VEGF Secretion

Cancerous cells are characterised by their ability to invade, metastasise, and induce angiogenesis. Tumour cells use various molecules that can be targeted to reverse these processes. Dasatinib, a potent Src inhibitor, has shown promising results in treating hepatocellular carcinoma (HCC) in vitro and in vivo. However, its effectiveness is limited by focal adhesion kinase (FAK) activation. Isothiocyanates, on the other hand, are phytochemicals with broad anticancer activity and FAK inhibition capabilities. This study evaluated the synergistic effect of dasatinib and phenethyl isothiocyanate (PEITC) on HCC. The combination was tested using various assays, including MTT, adhesion, scratch, Boyden chamber, chorioallantoic membrane (CAM), and yolk sac membrane (YSM) assays to evaluate the effect of the drug combination on HCC metastatic potential and angiogenesis in vitro and in vivo. The results showed that the combination inhibited the adhesion, migration, and invasion of HepG2 cells and reduced xenograft volume in the CAM assay. Additionally, the combination reduced angiogenesis in vitro, diminishing the growth of vessels in the tube formation assay. The inhibition of FAK/STAT3 signalling led to increased E-cadherin expression and reduced VEGF secretion, reducing HCC metastatic potential. Therefore, a combination of PEITC and dasatinib could be a potential therapeutic strategy for the treatment of HCC.