Miracle-dz/UniFAR-FTUs huggingface dataset:
FoodPro: A Web-Based Tool for Evaluating Covariance and Correlation NMR Spectra Associated with Food Processes

Foods from agriculture and fishery products are processed using various technologies. Molecular mixture analysis during food processing has the potential to help us understand the molecular mechanisms involved, thus enabling better cooking of the analyzed foods. To date, there has been no web-based tool focusing on accumulating Nuclear Magnetic Resonance (NMR) spectra from various types of food processing. Therefore, we have developed a novel web-based tool, FoodPro, that includes a food NMR spectrum database and computes covariance and correlation spectra to tasting and hardness. As a result, FoodPro has accumulated 236 aqueous (extracted in D2O) and 131 hydrophobic (extracted in CDCl3) experimental bench-top 60-MHz NMR spectra, 1753 tastings scored by volunteers, and 139 hardness measurements recorded by a penetrometer, all placed into a core database. The database content was roughly classified into fish and vegetable groups from the viewpoint of different spectrum patterns. FoodPro can query a user food NMR spectrum, search similar NMR spectra with a specified similarity threshold, and then compute estimated tasting and hardness, covariance, and correlation spectra to tasting and hardness. Querying fish spectra exemplified specific covariance spectra to tasting and hardness, giving positive covariance for tasting at 1.31 ppm for lactate and 3.47 ppm for glucose and a positive covariance for hardness at 3.26 ppm for trimethylamine N-oxide.
A Performance Assessment Support System for Advanced Software Systems

Performance measurement involves running a set of representative workloads, such as benchmarks, and quality assurance, which involves extensive testing. Most present-day benchmarks provide the user and system engineer with a few performance figures only (e.g. TPS: throughput in number of transaction per second). To compare two or more different software systems or evaluate a newly designed system, such figures are often not sufficient. A performance relationship between experimental factors and response variables is much harder and cumbersome to obtain, because more measurements have to be performed. Moreover, expertise in the area of experimental design is required to derive the performance relationships at minimal cost (time). The novel performance assessment support system (PASS), called “SOFTWARE TESTPILOT”, described in this paper greatly simplifies performance-assessment and -analysis of advanced database management systems by enabling a compact specification of the workload search space, a flexible mechanism to interact with a system under study, and a fast algorithm to expose the performance bottlenecks or software instabilities.
Dosimetry for photobiomodulation therapy : response to Sommers

In a recent article by Sommer et al. in Annals of Translational Medicine, the authors make several key comments on our recent article in Scientific Reports entitled “Molecular pathway of near infrared laser phototoxicity involves ATF4 orchestrated ER stress” (1). Firstly, we would like to thank the authors for their laudatory, constructive comments, specifically appreciating the rigorous effort and potential impact of our work. However, this editorial also raised a few key issues regarding methodology and interpretations in our study. We feel these points could be further clarified for the increasingly enthusiastic audience following nuances of photobiomodulation (PBM) therapy.
Oxygen saturation and breathing patterns in children.

OBJECTIVE To obtain information on breathing patterns and oxygenation in children. DESIGN Overnight tape recordings of arterial oxygen saturation (SaO2; Nellcor N200 in beat-to-beat mode), photoplethysmographic waveforms, and breathing movements in 70 healthy children (mean age 8.0 years, range 2 through 16). Analysis of recordings for pauses in breathing movements of > or = 4 seconds (apneic pauses), for episodes in which SaO2 fell to < or = 90% (desaturations) and, only during the state of regular breathing, for baseline SaO2, heart rate, and respiratory rate. RESULTS Both baseline heart rate and respiratory rate decreased with increasing age (r = -.7 and -.3, respectively, P < .01). Baseline SaO2 was similar to that previously observed in infants (median 99.5%, range 95.8 to 100, 5th centile 96.6%). Every recording showed apneic pauses, with a frequency that did not vary consistently with age (median 7.7/h, range 0.6 to 25.5). One hundred nineteen apneic pauses in 43 recordings lasted for 15 to 19.9 seconds, and 23 lasted for > or = 20 seconds (longest 28.8 seconds). The number of episodic falls in SaO2 to < or = 90% decreased with age (r = -.3, P < .01); such episodes were found in 47% of children aged 2 through 6 years, but in only 13% of those aged 12 through 16 years. The 95th centile for desaturation frequency in the total group was 0.6/h. In six episodes in four patients, SaO2 fell to < or = 80%. CONCLUSIONS Apneic pauses, some of which can last for more than 20 seconds, are a normal phenomenon in healthy children and adolescents, but only a small minority of apneic pauses affect blood gas homeostasis. Information concerning oxygenation may be more relevant to our understanding of the maturation of respiratory control than the recording of breathing signals alone.
Rapid and Sensitive Lentivirus Vector-Based Conditional Gene Expression Assay to Monitor and Quantify Cell Fusion Activity

Cell-to-cell fusion is involved in multiple fundamental biological processes. Prominent examples include osteoclast and giant cell formation, fertilization and skeletal myogenesis which involve macrophage, sperm-egg and myoblast fusion, respectively. Indeed, the importance of cell fusion is underscored by the wide range of homeostatic as well as pathologic processes in which it plays a key role. Therefore, rapid and sensitive systems to trace and measure cell fusion events in various experimental systems are in demand. Here, we introduce a bipartite cell fusion monitoring system based on a genetic switch responsive to the site-specific recombinase FLP. To allow flexible deployment in both dividing as well as non-dividing cell populations, inducer and reporter modules were incorporated in lentivirus vector particles. Moreover, the recombinase-inducible transcription units were designed in such a way as to minimize basal activity and chromosomal position effects in the “off” and “on” states, respectively. The lentivirus vector-based conditional gene expression assay was validated in primary human mesenchymal stem cells and in a differentiation model based on muscle progenitor cells from a Duchenne muscular dystrophy patient using reporter genes compatible with live- and single-cell imaging and with whole population measurements. Using the skeletal muscle cell differentiation model, we showed that the new assay displays low background activity, a 2-log dynamic range, high sensitivity and is amenable to the investigation of cell fusion kinetics. The utility of the bipartite cell fusion monitoring system was underscored by a study on the impact of drug- and RNAi-mediated p38 MAPK inhibition on human myocyte differentiation. Finally, building on the capacity of lentivirus vectors to readily generate transgenic animals the present FLP-inducible system should be adaptable, alone or together with Cre/loxP-based assays, to cell lineage tracing and conditional gene manipulation studies in vivo.
SATO–CRUTCHFIELD FORMULATION FOR SOME EVOLUTIONARY GAMES

The Sato–Crutchfield equations are analytically and numerically studied. The Sato–Crutchfield formulation corresponds to losing memory. Then the Sato–Crutchfield formulation is applied for some different types of games including hawk–dove, prisoner's dilemma and the battle of the sexes games. The Sato–Crutchfield formulation is found not to affect the evolutionarily stable strategy of the ordinary games. But choosing a strategy becomes purely random, independent of the previous experiences, initial conditions, and the rules of the game itself. The Sato–Crutchfield formulation for the prisoner's dilemma game can be considered as a theoretical explanation for the existence of cooperation in a population of defectors.
Cerebral Microemboli During Hip Fracture Fixation: A Prospective Study

BACKGROUND: Recent studies have shown that cerebral fat microembolism takes place during surgery for hip or knee replacement. In this study, we examined the occurrence of cerebral microembolism, solid or gas, during a standard procedure of hip fracture fixation. METHODS: This was a prospective study of patients who underwent urgent surgery with a dynamic hip screw for hip fracture fixation. During surgery, patients were monitored with transcranial Doppler for detection of microemboli from right and left middle cerebral arteries. RESULTS: Twenty-two patients were included in the study; their median age was 82 yr (range, 51–97 yr). In nine (41%) patients, high intensity transient signals were recorded, indicating microemboli passage in the middle cerebral arteries. All nine patients had signals of both solid and gas emboli. One of these nine patients had a postoperative cerebrovascular accident. CONCLUSIONS: The incidence of cerebral microemboli during urgent surgery for hip fracture fixation is considerable. This phenomenon is not confined to hip or knee replacement surgery. The clinical implications of this finding require further investigation.
JENNERIAN PROPHYLAXIS BY MEANS OF INTRADERMAL INJECTIONS OF CULTURE VACCINE VIRUS

The second revived strain of culture vaccine virus has been propagated through 130 culture passages during a period of 3 years. It seems to be adapted to in vitro cultivation and still has an intradermal titer (rabbits) of 1 to 100,000 or 1 to 1,000,000. Intradermal inoculations in human beings of 0.1 cc. amounts of culture virus diluted from 2.5 to 10 times result in primary takes in unvaccinated people and immune reactions or accelerated takes in individuals previously successfully vaccinated. Primary takes produce an immunity to standard strains of calf lymph. Culture virus mixed with purified gum acacia (2.5 per cent), frozen, desiccated, and sealed in vacuo retains its activity for a month at 37°C. , and when the dried virus is resuspended in saline solution it is suitable for intradermal vaccination of human beings.
Serum Concentrations of Th17-Associated Interleukins and Autoimmune Phenomena are Associated with the Degree of Liver Damage in Alcoholic Liver Disease.

BACKGROUND AND AIMS Recent reports suggest an involvement of Th17 responses in inflammatory and autoimmune reactions in alcoholic liver disease (ALD). Our study aimed to assess serum levels of Th17-interleukins in ALD with regard to the frequency of liver-specific autoantibodies and degree of liver damage. METHODS Ninety-five patients with ALD were enrolled. Serum concentrations of IL-17F, IL-17A, IL-22 were assessed by ELISA. The presence of autoantibodies AMA-M2, SLA/LP, LKM-1, LC1, anti-F-actin, anti-desmin and anti-myosin in serum was assessed by immunoblotting, ANA antibodies were detected by ELISA. The results were analysed with regard to the degree of hepatic damage. RESULTS Serum IL-17F was significantly elevated in ALD patients compared to controls (p=0.03). There was a correlation between serum IL-17F and degree of liver failure evaluated by the MELD score (rs=0.23, p=0.03). Serum IL-22 also correlated with MELD score (rs=0.32, p=0.007) and CTP score (rs=0.28, p=0.02). Anti-F-actin antibodies were present in 19% and ANA-antibodies in 11% of the patients in the study group, and in no subjects in the control group. The prevalence of anti-F-actin autoantibodies was higher in subjects with more advanced liver diseases but also independently associated with IL-17A in the regression analysis. Furthermore, serum IL-22 in anti-F-actin(+)-patients was significantly higher compared to anti-F-actin(-)-patients (p=0.03). CONCLUSIONS Elevation of serum IL-17A, IL-17F, IL-22 correlated with the progression of liver damage and also with presence of F-actin in ALD. Alcoholic liver disease may trigger autoimmunity and formation of autoantibodies, especially anti-F-actin, with possible engagement of Th17-related cytokines in this process.
Effect of halotolerant rhizobacteria isolated from halophytes on the growth of sugar beet (Beta vulgaris L.) under salt stress

Utilization of rhizobacteria that have associated with plant roots in harsh environments could be a feasible strategy to deal with limits to agricultural production caused by soil salinity. Halophytes occur naturally in high-salt environments, and their roots may be associated with promising microbial candidates for promoting growth and salt tolerance in crops. This study aimed to isolate efficient halotolerant plant-growth-promoting rhizobacterial strains from halophytes and evaluate their activity and effects on sugar beet (Beta vulgaris L.) growth under salinity stress. A total of 23 isolates were initially screened for their ability to secrete 1-aminocyclopropane-1-carboxylate deaminase (ACD) as well as other plant-growth-promoting characteristics and subsequently identified by sequencing the 16S rRNA gene. Three isolates, identified as Micrococcus yunnanensis, Planococcus rifietoensis and Variovorax paradoxus, enhanced salt stress tolerance remarkably in sugar beet, resulting in greater seed germination and plant biomass, higher photosynthetic capacity and lower stress-induced ethylene production at different NaCl concentrations (50-125 mM). These results demonstrate that salinity-adapted, ACD-producing bacteria isolated from halophytes could promote sugar beet growth under saline stress conditions.
Pronunciation modelling using a hand-labelled corpus for conversational speech recognition

Accurately modelling pronunciation variability in conversational speech is an important component of an automatic speech recognition system. We describe some of the projects undertaken in this direction during and after WS97, the Fifth LVCSR Summer Workshop, held at Johns Hopkins University, Baltimore, in July-August, 1997. We first illustrate a use of hand-labelled phonetic transcriptions of a portion of the Switchboard corpus, in conjunction with statistical techniques, to learn alternatives to canonical pronunciations of words. We then describe the use of these alternate pronunciations in an automatic speech recognition system. We demonstrate that the improvement in recognition performance from pronunciation modelling persists as the system is enhanced with better acoustic and language models.
Generation of Antigen Microarrays to Screen for Autoantibodies in Heart Failure and Heart Transplantation

Autoantibodies directed against endogenous proteins including contractile proteins and endothelial antigens are frequently detected in patients with heart failure and after heart transplantation. There is evidence that these autoantibodies contribute to cardiac dysfunction and correlate with clinical outcomes. Currently, autoantibodies are detected in patient sera using individual ELISA assays (one for each antigen). Thus, screening for many individual autoantibodies is laborious and consumes a large amount of patient sample. To better capture the broad-scale antibody reactivities that occur in heart failure and post-transplant, we developed a custom antigen microarray technique that can simultaneously measure IgM and IgG reactivities against 64 unique antigens using just five microliters of patient serum. We first demonstrated that our antigen microarray technique displayed enhanced sensitivity to detect autoantibodies compared to the traditional ELISA method. We then piloted this technique using two sets of samples that were obtained at our institution. In the first retrospective study, we profiled pre-transplant sera from 24 heart failure patients who subsequently received heart transplants. We identified 8 antibody reactivities that were higher in patients who developed cellular rejection (2 or more episodes of grade 2R rejection in first year after transplant as defined by revised criteria from the International Society for Heart and Lung Transplantation) compared with those who did have not have rejection episodes. In a second retrospective study with 31 patients, we identified 7 IgM reactivities that were higher in heart transplant recipients who developed antibody-mediated rejection (AMR) compared with control recipients, and in time course studies, these reactivities appeared prior to overt graft dysfunction. In conclusion, we demonstrated that the autoantibody microarray technique outperforms traditional ELISAs as it uses less patient sample, has increased sensitivity, and can detect autoantibodies in a multiplex fashion. Furthermore, our results suggest that this autoantibody array technology may help to identify patients at risk of rejection following heart transplantation and identify heart transplant recipients with AMR.
RSSI estimation using Bluetooth in smart phones

The “On-Time” communication has become an tremendous implication in the real world scenarios. Moreover the problem of proximity estimation is found to be difficult in a variety of environment. Existing approaches such as Global Positioning System and Wi-Fi triangulations are insufficient to meet the requirements of accuracy and also requires high cost. In this paper, the Bluetooth which is commonly available in all Smartphone's are used to find the proximity over a shorter distance and also this paper provides an estimation model to determine the distance based on the Received Signal Strength Indicator values of the Bluetooth. In order to provide a high accuracy in finding the proximity the Values of atmospheric pressure and light sensor data are also collected and used in the RSSI estimation. For every 30sec these values are updated in the cloud server technology and thus the "On Time" proximity estimation between the devices can be determined based on the RSSI values of Bluetooth in different environments with high accuracy and low cost.
Fulminant hepatic failure in an HBsAg carrier renal transplant patient following cessation of immunosuppressive therapy.

Une observation. La malade etait asymtomatique malgre quelques resultats anormaux des epreuves fonctionnelles hepatiques entre 1978 et 1982. L'interruption des immunodepresseurs (a l'occasion d'une peritonite postoperatoire) est suivie d'une insuffisance hepatique aigue mortelle. Les cellules hepatiques infectees pendant l'immunodepression ont sans doute ete detruites repidement lors du retour de l'immunocompetence, provoquant la necrose massive. Dans de tels cas, une reduction progressive des immunodepresseurs serait preferable
Phonetic landmark detection for automatic language identification

This paper presents a method of augmenting shifted-delta cepstral coefficients (SDCCs) with the classification outputs of an array of support vector machines (SVMs) trained to detect a set of manner and place features on telephone speech. The SVM array allows for broad phoneme classification, and when this information is concatenated with SDCCs to form a hybrid feature vector for each acoustic frame, a set of Gaussian mixture models (GMMs) may be trained to perform automatic language identification (LID). The NTIMIT telephone band speech corpus was used to train the SVM-based distinctive feature recognizers, while the NIST callfriend telephone corpus was used for training and testing the rest of the system.
Maintaining mutual consistency for cached Web objects

Existing Web proxy caches employ cache consistency mechanisms to ensure that locally cached data is consistent with that at the server. We argue that techniques for maintaining consistency of individual objects are not sufficient; a proxy should employ additional mechanisms to ensure that related Web objects are mutually consistent with one another. We formally define the notion of mutual consistency and the semantics provided by a mutual consistency mechanism to end users. We then present techniques for maintaining mutual consistency in the temporal and value domains. A novel aspect of our techniques is that they can adapt to the variations in the rate of change of the source data, resulting in judicious use of proxy and network resources. We evaluate our approaches using real-world Web traces and show that: (i) careful tuning can result in substantial savings in the network overhead incurred without any substantial loss in fidelity, of the consistency guarantees, and (ii) the incremental cost of providing mutual consistency guarantees over mechanisms to provide individual consistency guarantees is small.
Controlled Genetic Programming Search for Solving Deceptive Problems

CONTROLLED GENETIC PROGRAMMING SEARCH FOR SOLVING DECEPTIVE PROBLEMS Korkmaz, Emin Erkan Ph.D., Department of Computer Engineering Supervisor: Asso . Prof. Dr. G okt urk  U oluk Mar h 2003, 77 pages Traditional Geneti Programming randomly ombines subtrees by applying rossover. There is a growing interest in methods that an ontrol su h re ombination operations. In this thesis, a new approa h is presented for guiding the re ombination pro ess for Geneti Programming. The method is based on extra ting the global information of the promising solutions that appear during the geneti sear h. The aim is to use this information to ontrol the rossover operation afterwards. A separate ontrol module is used to pro ess the olle ted information. This module guides the sear h pro ess by sending feedba k to the geneti engine about the onsequen es of possible re ombination alternatives.
Seroma Prevention by Using Corynebacterium parvum in a Rat Mastectomy Model

Seroma formation is the most common complication after mastectomy and continues to be an important problem during the early postoperative period. Several surgical and medical methods have been developed to try to overcome this problem; however, so far none have been used successfully in the routine clinical practice. The aim of this study is to evaluate the effects of Corynebacterium parvum (CP) as a sclerosing agent in both prevention and treatment of seromas after mastectomy and axillary dissection in an animal model. Sixty female Sprague-Dawley rats underwent mastectomy and axillary dissection under general anaesthesia. Following surgery, the rats were treated in 1 of 3 ways. In the prevention group, 1 cm3 (0.35 mg) CP solution was injected beneath the skin flap just before closure of the incision after mastectomy. In the treatment group, animals in which a seroma was formed, the fluid was aspirated, and 1 cm3 CP solution was injected beneath the flap. In the control group, animals in which seromas formed, aspiration only was performed. The frequency of seroma formation decreased when CP solution was injected immediately after the operation (p < 0.01). In addition, seroma formation was effectively treated by CP injection when compared with the control group (p < 0.05). CP was effective as a prophylactic agent in the prevention group and as a therapeutic agent in the treatment group in this experimental model. CP injection may be useful for the management of this problem in a clinical setting.