Miracle-dz/UniFAR-FTUs huggingface dataset:
Research on Integration Framework of Web-based Learning System Based on Web services, Ontology and Web Widget

Web service is a service-oriented architecture which can achieve real platform-independent and language-independent. Ontology is a formal representation of the knowledge by a set of concepts within a domain and the relationships between those concepts. In this paper, we analyzed the key technologies and architecture of Web services and discus one such approach that involves adding semantics to WSDL and UDDI using OWL ontologies in order to describe and discover Web Services accurately for us. Based on some problems of current Web-based Learning system, we propose Integration Framework of Web-based Learning System Based on Web services, Ontology and Web Widget(IFWBLS-WSOW) and give out an prototype realized by Microsoft.NET platform.
A cross-linguistic study of metaphors of death

The avoidance of directly addressing human mortality indicates fear of death. This fear elicits psychological, social and religious interdictions in language such that people resort to the use of metaphors to avoid confronting death. Under the premise that metaphor is a conceptual mapping from a concrete source to an abstract target domain, this study aims to identify and categorize euphemistic metaphors of death in six languages: Chinese, Farsi, Gĩkũyũ, Russian, Spanish, and Swedish. Those metaphors are interpreted via the Conceptual Metaphor Theory (CMT). In doing so, 40 speakers in each of the languages were asked to complete a short questionnaire. Various metaphors of death were identified in each language and categorized into four conceptual metaphors: death is a journey; death is the end; death is a rest; and death is a summons. The key finding is that the most common metaphor of death is death is a journey. This holds across linguistic groups regardless of gender and age factors. This study also discusses the role of embodied cognition theories in accounting for how metaphors of death are created and their role within cognition in general.
Exploring portfolio scheduling for long-term execution of scientific workloads in IaaS clouds

Long-term execution of scientific applications often leads to dynamic workloads and varying application requirements. When the execution uses resources provisioned from IaaS clouds, and thus consumption-related payment, efficient and online scheduling algorithms must be found. Portfolio scheduling, which selects dynamically a suitable policy from a broad portfolio, may provide a solution to this problem. However, selecting online the right policy from possibly tens of alternatives remains challenging. In this work, we introduce an abstract model to explore this selection problem. Based on the model, we present a comprehensive portfolio scheduler that includes tens of provisioning and allocation policies. We propose an algorithm that can enlarge the chance of selecting the best policy in limited time, possibly online. Through trace-based simulation, we evaluate various aspects of our portfolio scheduler, and find performance improvements from 7% to 100% in comparison with the best constituent policies and high improvement for bursty workloads.
Zuni Adolescent Suicide.

This paper provides information regarding a joint curriculum project between Stanford University and the Pueblo of Zuni in New Mexico. The project is an outgrowth of the Stanford/Zuni Committee, a unique collaborative effort that is guarded by sensitivity to previous Indian research experiences and a commitment to useful consultation with the tribe. This report presents the epidemiology of Zuni suicide and notes that the suicide rate of Indian youth is three times that of white youth. Treatment programs used in other reservation commlnities are briefly reviewed. The document describes the Stanford prevention strategy, which uses a social skills training model. The project operates under the belief that favorable outcomes could result from the use of an intervention that focuses primarily on developing students the independent use of target skills outside the school context. Although the project is not complete, it is hoped that Zuni students will be able to regulate their own behavior better as they acquire the transactional skills of coping. The project's curriculum and proposed implementation plan are described in detail. (TES) *********************************************************************** * Reproductions supplied by EDRS are the best that can be made * * from the original document. * *********************************************************************** Zuni Adolescent Suicide Mary Jiron Belgarde and Teresa LaFromboise
Projections in the Space H ∞ and the Corona Theorem for Coverings of Bordered Riemann Surfaces

Let M be a non-compact connected Riemann surface of finite type, and R ⊂⊂ M be a relatively compact domain such that H1(M,Z) = H1(R,Z). Let R̃ −→ R be a covering. We study the algebra H∞(U) of bounded holomorphic functions defined in some domains U ⊂ R̃. Our main result is a Forelli type theorem on projections in H∞(D).
On Space Information Flow: Single multicast

Departing from Network Information Flow (NIF) that studies network coding in graphs, Space Information Flow (SIF) is a new paradigm that studies network coding in a geometric space. This work focuses on the problem of min-cost multicast network coding in a 2-dimensional Euclidean space. We prove a number of properties of the optimal SIF solutions, and propose a two-phase heuristic algorithm for computing the optimal SIF. The first phase computes the optimal topology through space partitioning that translates the SIF problem into a NIF problem, which is then solved using linear optimization. The second phase computes the min-cost embedding of the SIF topology found in the first phase, by fine tuning the location of each relay node using properties that an optimal SIF must satisfy.
Individuals motion models based on probabilistic distribution profiles

The motion models of individuals should mathematically describe, as well as possible, the movements executed by an individual when he is walking, running or even stopping. There are some references in the literature with respect to individuals motion models, but most of them are based on image processing. In this paper, we proposed three probabilistic distribution profiles that can model the heading angle of an individual trajectory without relying on image processing. These profiles are based on probability density functions and cumulative distribution functions. Objectivity tests and standard deviation analysis were made in order to verify each profile behavior.
A Network of Multi-Tasking Proteins at the DNA Replication Fork Preserves Genome Stability

To elucidate the network that maintains high fidelity genome replication, we have introduced two conditional mutant alleles of DNA2, an essential DNA replication gene, into each of the approximately 4,700 viable yeast deletion mutants and determined the fitness of the double mutants. Fifty-six DNA2-interacting genes were identified. Clustering analysis of genomic synthetic lethality profiles of each of 43 of the DNA2-interacting genes defines a network (consisting of 322 genes and 876 interactions) whose topology provides clues as to how replication proteins coordinate regulation and repair to protect genome integrity. The results also shed new light on the functions of the query gene DNA2, which, despite many years of study, remain controversial, especially its proposed role in Okazaki fragment processing and the nature of its in vivo substrates. Because of the multifunctional nature of virtually all proteins at the replication fork, the meaning of any single genetic interaction is inherently ambiguous. The multiplexing nature of the current studies, however, combined with follow-up supporting experiments, reveals most if not all of the unique pathways requiring Dna2p. These include not only Okazaki fragment processing and DNA repair but also chromatin dynamics.
Virulence Differences Among Francisella tularensis Subsp. tularensis Clades in Mice

Francisella tularensis subspecies tularensis (type A) and holarctica (type B) are of clinical importance in causing tularemia. Molecular typing methods have further separated type A strains into three genetically distinct clades, A1a, A1b and A2. Epidemiological analyses of human infections in the United States suggest that A1b infections are associated with a significantly higher mortality rate as compared to infections caused by A1a, A2 and type B. To determine if genetic differences as defined by molecular typing directly correlate with differences in virulence, A1a, A1b, A2 and type B strains were compared in C57BL/6 mice. Here we demonstrate significant differences between survival curves for infections caused by A1b versus A1a, A2 and type B, with A1b infected mice dying earlier than mice infected with A1a, A2 or type B; these results were conserved among multiple strains. Differences were also detected among type A clades as well as between type A clades and type B with respect to bacterial burdens, and gross anatomy in infected mice. Our results indicate that clades defined within F. tularensis subsp. tularensis by molecular typing methods correlate with virulence differences, with A1b strains more virulent than A1a, A2 and type B strains. These findings indicate type A strains are not equivalent with respect to virulence and have important implications for public health as well as basic research programs.
Analysis of Click Stream Patterns using Soft Biclustering Approaches

As websites increase in complexity, locating needed information becomes a difficult task. Such difficulty is often related to the websites' design but also ineffective and inefficient navigation processes. Research in web mining addresses this problem by applying techniques from data mining and machine learning to web data and documents. In this study, the authors examine web usage mining, applying data mining techniques to web server logs. Web usage mining has gained much attention as a potential approach to fulfill the requirement of web personalization. In this paper, the authors propose K-means biclustering, rough biclustering and fuzzy biclustering approaches to disclose the duality between users and pages by grouping them in both dimensions simultaneously. The simultaneous clustering of users and pages discovers biclusters that correspond to groups of users that exhibit highly correlated ratings on groups of pages. The results indicate that the fuzzy C-means biclustering algorithm best and is able to detect partial matching of preferences.
Validation of the Antiproliferative Effects of Organic Extracts from the Green Husk of Juglans regia L. on PC-3 Human Prostate Cancer Cells by Assessment of Apoptosis-Related Genes

With the increased use of plant-based cancer chemotherapy, exploring the antiproliferative effects of phytochemicals for anticancer drug design has gained considerable attention worldwide. This study was undertaken to investigate the effect of walnut green husk extracts on cell proliferation and to determine the possible molecular mechanism of extract-induced cell death by quantifying the expression of Bcl-2, Bax, caspases-3, and Tp53. PC-3 human prostate cancer cells. In this study, we found that green husk extracts suppressed proliferation and induced apoptosis in a dose- and time-dependent manner by modulating expression of apoptosis-related genes. This involved DNA fragmentation (determined by TUNEL assay) and significant changes in levels of mRNA and the expression of corresponding proteins. An increase in expressions of Bax, caspase-3, and tp53 genes and their corresponding proteins was detected using real-time PCR and western blot analysis in PC-3 cells treated with the green husk organic extracts. In contrast, Bcl2 expression was downregulated after exposure to the extracts. Our data suggest the presence of bioactive compound(s) in walnut green husks that are capable of killing prostate carcinoma cells by inducing apoptosis and that the husks are a candidate source of anticancer drugs.
Adding Contracts to Java with Handshake

Contracts describe an agreement between the writer and the user of a class. Their use enhances programmer productivity and program reliability, especially in library code. Handshake provides contracts for Java classes and interfaces in the form of class invariants and method pre- and postconditions. Using Handshake, a programmer can add contracts to classes and interfaces without needing access to their source code, without changing the class files, and without changing the JVM implementation. Unlike existing implementations of contracts for Java, Handshake intercepts the VM''s file operations and modifies classes on the fly without requiring any modification to the JVM itself. By using a dynamic link library interposed between the VM and the operating system, the system is relatively simple to port to a new OS and works with a variety of JVM implementations. The system imposes very little overhead other than the time required to evaluate the contract''s boolean expressions themselves.
GPLSI-IXA: Using Semantic Classes to Acquire Monosemous Training Examples from Domain Texts

This paper summarizes our participation in task #17 of SemEval--2 (All--words WSD on a specific domain) using a supervised class-based Word Sense Disambiguation system. Basically, we use Support Vector Machines (SVM) as learning algorithm and a set of simple features to build three different models. Each model considers a different training corpus: SemCor (SC), examples from monosemous words extracted automatically from background data (BG), and both SC and BG (SCBG). Our system explodes the monosemous words appearing as members of a particular WordNet semantic class to automatically acquire class-based annotated examples from the domain text. We use the class-based examples gathered from the domain corpus to adapt our traditional system trained on SemCor. The evaluation reveal that the best results are achieved training with SemCor and the background examples from monosemous words, obtaining results above the first sense baseline and the fifth best position in the competition rank.
Missed Opportunities for the Diagnosis of Colorectal Cancer

Objective. To examine patient and medical characteristics which predict a missed diagnostic opportunity (MDO) for colorectal cancer (CRC). Methods. The sample consisted of 252 patients diagnosed with Stages 1–4 CRC who were diagnosed in the prior six months, had experienced symptoms prior to diagnosis, and were not diagnosed through routine screening. Systematic review of all medical records prior to patients' diagnosis was conducted. An MDO was defined as a clinical encounter where, even in the presence of presumptive CRC symptoms, the CRC diagnostic process is not started. Results. 92 patients (36.5%) experienced an MDO. Almost 80% of alternate diagnoses were other GI-GU diseases, including hemorrhoids and diverticulitis. Stomach pain, anemia, and constipation were the most common symptoms experienced by the MDO group. These symptoms, and weight loss and vomiting, were more likely to be noted in the charts of the MDO patients (P < 0.04). Independent risk factors for MDO included age (<50) [OR = 2.29 (1.14–4.60), P = 0.02] and female sex [OR = 2.19 (1.16–4.16), P = 0.03]. Each additional physician seen, more than doubled the MDO risk [OR = 2.05 (1.53–2.74), P < 0.001]. Conclusions. Females, younger patients, and those consulting more physicians were all more likely to experience an MDO. Continued increased training of physicians to enhance knowledge of who is vulnerable to CRC is needed in addition to an increased focus to adherence to screening recommendations.
Plexin-A4 Mediates Axon-Repulsive Activities of Both Secreted and Transmembrane Semaphorins and Plays Roles in Nerve Fiber Guidance

It has been proposed that four members of the plexin A subfamily (plexin-As; plexin-A1, -A2, -A3, and -A4) and two neuropilins (neuropilin-1 and neuropilin-2) form complexes and serve as receptors for class 3 secreted semaphorins (Semas), potent neural chemorepellents. The roles of given plexin-As in semaphorin signaling and axon guidance, however, are mostly unknown. Here, to elucidate functions of plexin-A4 in semaphorin signaling and axon guidance events in vivo, we generated plexin-A4 null mutant mice by targeted disruption of the plexin-A4 gene. Plexin-A4 mutant mice were defective in the trajectory and projection of peripheral sensory axons and sympathetic ganglion (SG) axons and the formation of the anterior commissure and the barrels. The defects in peripheral sensory and SG axons were fundamentally related to those of neuropilin-1 or Sema3A mutant embryos reported but were more moderate than the phenotype in these mutants. The growth cone collapse assay showed that dorsal root ganglion axons and SG axons of plexin-A4 mutant embryos partially lost their responsiveness to Sema3A. These results suggest that plexin-A4 plays roles in the propagation of Sema3A activities and regulation of axon guidance and that other members of the plexin-A subfamily are also involved in the propagation of Sema3A activities. Plexin-A4-deficient SG axons did not lose their responsiveness to Sema3F, suggesting that plexin-A4 serves as a Sema3A-specific receptor, at least in SG axons. In addition, the present study showed that plexin-A4 bound class 6 transmembrane semaphorins, Sema6A and Sema6B, and mediated their axon-repulsive activities, independently of neuropilin-1. Our results imply that plexin-A4 mediates multiple semaphorin signals and regulates axon guidance in vivo.
Will the Internet Channel Lead to Disintermediation?

The explosive growth in Internet usage has changed the ways companies do business. One of the most frequently discussed effects of the emergence of the Internet channel has been disintermediation. The purpose of this paper is to investigate whether the growing e-business armed with the Internet channel will lead to disintermediation. This research question is explored within a game theoretic model capturing the fundamental difference between the physical store and the Internet channel. The model also captures the heterogeneity in buyer preference for the Internet channel as well as that for the physical store. The closed form equilibrium solutions of the model reveal a negative incentive of disintermediation. The intuitions and implications are discussed.
A closedness condition and its applications to DC programs with convex constraints

This paper concerns a closedness condition called (CC) involving a convex function and a convex constrained system. This type of condition has played an important role in the study of convex optimization problems. Our aim is to establish several characterizations of this condition and to apply them to study problems of minimizing a DC function under a cone-convex constraint and a set constraint. First, we establish several so-called ‘Toland–Fenchel–Lagrange’ duality theorems. As consequences, various versions of generalized Farkas lemmas in dual forms for systems involving convex and DC functions are derived. Then, we establish optimality conditions for DC problem under convex constraints. Optimality conditions for convex problems and problems of maximizing a convex function under convex constraints are given as well. Most of the results are established under the (CC) condition. This article serves as a link between several corresponding known ones published recently for DC programs and for convex programs.
Cancer-targeted IL-12 controls human rhabdomyosarcoma by senescence induction and myogenic differentiation

Stimulating the immune system to attack cancer is a promising approach, even for the control of advanced cancers. Several cytokines that promote interferon-γ-dominated immune responses show antitumor activity, with interleukin 12 (IL-12) being of major importance. Here, we used an antibody-IL-12 fusion protein (NHS-IL12) that binds histones of necrotic cells to treat human sarcoma in humanized mice. Following sarcoma engraftment, NHS-IL12 therapy was combined with either engineered IL-7 (FcIL-7) or IL-2 (IL-2MAB602) for continuous cytokine bioavailability. NHS-IL12 strongly induced innate and adaptive antitumor immunity when combined with IL-7 or IL-2. NHS-IL12 therapy significantly improved survival of sarcoma-bearing mice and caused long-term remissions when combined with IL-2. NHS-IL12 induced pronounced cancer cell senescence, as documented by strong expression of senescence-associated p16INK4a and nuclear translocation of p-HP1γ, and permanent arrest of cancer cell proliferation. In addition, this cancer immunotherapy initiated the induction of myogenic differentiation, further promoting the hypothesis that efficient antitumor immunity includes mechanisms different from cytotoxicity for efficient cancer control in vivo.
Guidelines for the Diagnosis and Treatment of Chronic Functional Constipation in Korea, 2015 Revised Edition

The Korean Society of Neurogastroenterology and Motility first published guidelines for chronic constipation in 2005 and was updated in 2011. Although the guidelines were updated using evidence-based process, they lacked multidisciplinary participation and did not include a diagnostic approach for chronic constipation. This article includes guidelines for diagnosis and treatment of chronic constipation to realistically fit the situation in Korea and to be applicable to clinical practice. The guideline development was based upon the adaptation method because research evidence was limited in Korea, and an organized multidisciplinary group carried out systematical literature review and series of evidence-based evaluations. Six guidelines were selected using the Appraisal of Guidelines for Research & Evaluation (AGREE) II process. A total 37 recommendations were adopted, including 4 concerning the definition and risk factors of chronic constipation, 8 regarding diagnoses, and 25 regarding treatments. The guidelines are intended to help primary physicians and general health professionals in clinical practice in Korea, to provide the principles of medical treatment to medical students, residents, and other healthcare professionals, and to help patients for choosing medical services based on the information. These guidelines will be updated and revised periodically to reflect new diagnostic and therapeutic methods.
Geotechnical properties of a municipal water treatment sludge incorporating a coagulant

The geotechnical properties of a municipal water treatment sludge from an upland catchment are presented. The gelatinous sludge comprised flocs of mainly quartz, manganoan calcite, and clay-sized organic solids, and incorpo- rated an alum coagulant and an anionic polyelectrolyte. Standard Proctor compaction yielded low bulk density values of 0.95-1.10 t/m 3 and dry density values of 0.12-0.36 t/m 3 (water content is 160%-780%) in line with the low specific gravity of solids value of 1.86. The undrained shear strength and the water content were inversely related on a semi-log plot. The effective stress shear strength parameter values were c' = 0 and � ' =3 98. The consolidation properties were studied using the oedometer, consolidometer, and triaxial apparatus. The material was highly compressible with primary compression index (Cc) values of 2.5-3.7, and primary compression ratio (C*c) values of 0.20-0.28. The majority of the strain response occurred due to primary consolidation although the material had a very low permeability (coefficient of permeability values decreasing from 2 � 10 -9 to 5 � 10 -11 m/s for an effective vertical stress of s'v = 3-800 kPa). Sec- ondary compression was minor, with a mean secondary compression index (Ce) value of 0.15, and Ce/Cc = 0.04-0.06.