Miracle-dz/UniFAR-FTUs huggingface dataset:
Opposite associations of age-dependent insulin-like growth factor-I standard deviation scores with nutritional state in normal weight and obese subjects.

OBJECTIVE Insulin-like growth factor-I (IGF-I) has been suggested to be a prognostic marker for the development of cancer and, more recently, cardiovascular disease. These diseases are closely linked to obesity, but reports of the association of IGF-I with measures of obesity are divergent. In this study, we assessed the association of age-dependent IGF-I standard deviation scores with body mass index (BMI) and intra-abdominal fat accumulation in a large population. DESIGN A cross-sectional, epidemiological study. METHODS IGF-I levels were measured with an automated chemiluminescence assay system in 6282 patients from the DETECT study. Weight, height, and waist and hip circumference were measured according to the written instructions. Standard deviation scores (SDS), correcting IGF-I levels for age, were calculated and were used for further analyses. RESULTS An inverse U-shaped association of IGF-I SDS with BMI, waist circumference, and the ratio of waist circumference to height was found. BMI was positively associated with IGF-I SDS in normal weight subjects, and negatively associated in obese subjects. The highest mean IGF-I SDS were seen at a BMI of 22.5-25 kg/m2 in men (+0.08), and at a BMI of 27.5-30 kg/m2 in women (+0.21). Multiple linear regression models, controlling for different diseases, medications and risk conditions, revealed a significant negative association of BMI with IGF-I SDS. BMI contributed most to the additional explained variance to the other health conditions. CONCLUSIONS IGF-I standard deviation scores are decreased in obesity and underweight subjects. These interactions should be taken into account when analyzing the association of IGF-I with diseases and risk conditions.
From point defects to plate tectonic faults

Understanding and explaining emergent constitutive laws in the multi-scale evolution from point defects, dislocations and two-dimensional defects to plate tectonic scales is an arduous challenge in condensed matter physics. The Earth appears to be the only planet known to have developed stable plate tectonics as a means to get rid of its heat. The emergence of plate tectonics out of mantle convection appears to rely intrinsically on the capacity to form extremely weak faults in the top 100 km of the planet. These faults have a memory of at least several hundred millions of years, yet they appear to rely on the effects of water on line defects. This important phenomenon was first discovered in laboratory and dubbed “hydrolytic weakening”. At the large scale it explains cycles of co-located resurgence of plate generation and consumption (the Wilson cycle), but the exact physics underlying the process itself and the enormous spanning of scales still remains unclear. We present an attempt to use the multi-scale non-equilibrium thermodynamic energy evolution inside the deforming lithosphere to move phenomenological laws to laws derived from basic scaling quantities, develop self-consistent weakening laws at lithospheric scale and give a fully coupled deformation-weakening constitutive framework. At meso- to plate scale we encounter in a stepwise manner three basic domains governed by the diffusion/reaction time scales of grain growth, thermal diffusion and finally water mobility through point defects in the crystalline lattice. The latter process governs the planetary scale and controls the stability of its heat transfer mode.
Nearest Neighbor Classifier with Optimal Stability

Stability has been of a great concern in statistics: similar statistical conclusions should be drawn based on different data sampled from the same population. In this article, we introduce a general measure of classification instability (CIS) to capture the sampling variability of the predictions made by a classification procedure. The minimax rate of CIS is established for general plug-in classifiers. As a concrete example, we consider the stability of the nearest neighbor classifier. In particular, we derive an asymptotically equivalent form for the CIS of a weighted nearest neighbor classifier. This allows us to develop a novel stabilized nearest neighbor classifier which well balances the trade-off between classification accuracy and stability. The resulting classification procedure is shown to possess the minimax optimal rates in both excess risk and CIS. Extensive experiments demonstrate a significant improvement of CIS over existing nearest neighbor classifiers at an ignorable cost of classification accuracy.
A systematic review of evidence for psychological treatments in eating disorders: 2005-2012.

OBJECTIVE To update new evidence for psychotherapies in eating disorders (EDs) since 2005-September 2012. METHOD Completed and published in the English language randomized controlled trials (RCTs) were identified by SCOPUS search using terms "bulimia" or "binge eating disorder" (BED) or "anorexia nervosa" (AN) or "eating disorder" and "treatment," and 36 new RCTs met inclusion criteria. RESULTS There has been progress in the evidence for family based treatment in adolescents with AN, for cognitive behavior therapy (CBT) in full and guided forms, and new modes of delivery for bulimia nervosa (BN), BED, and eating disorder not otherwise specified with binge eating. Risk of bias was low to moderate in 22 (61%) of RCTs. DISCUSSION The evidence base for AN has improved and CBT has retained and extended its status as first-line therapy for BN. However, further research is needed, in particular noninferiority trials of active therapies and the best approach to addressing ED features and weight management in co-morbid BED and obesity.
APIs à gogo: Automatic Generation of Ontology APIs

When developing application programming interfaces of ontologies that include many instances of ontology design patterns, developers of semantic web applications usually have to handle complex mappings between descriptions of information given by ontologies and object oriented representations of the same information. In current approaches, annotations on API source code handle these mappings, leading to problems with reuse and maintenance. We propose a domain-specific language to tackle these mappings in a platform independent way – agogo. Agogo provides improvements on software engineering quality attributes like usability, reusability, maintainability, and portability.
The MacBlue Binary Transgene (csf1r-gal4VP16/UAS-ECFP) Provides a Novel Marker for Visualisation of Subsets of Monocytes, Macrophages and Dendritic Cells and Responsiveness to CSF1 Administration

The MacBlue transgenic mouse uses the Csf1r promoter and first intron to drive expression of gal4-VP16, which in turn drives a cointegrated gal4-responsive UAS-ECFP cassette. The Csf1r promoter region used contains a deletion of a 150 bp conserved region covering trophoblast and osteoclast-specific transcription start sites. In this study, we examined expression of the transgene in embryos and adult mice. In embryos, ECFP was expressed in the large majority of macrophages derived from the yolk sac, and as the liver became a major site of monocytopoiesis. In adults, ECFP was detected at high levels in both Ly6C+ and Ly6C- monocytes and distinguished them from Ly6C+, F4/80+, CSF1R+ immature myeloid cells in peripheral blood. ECFP was also detected in the large majority of microglia and Langerhans cells. However, expression was lost from the majority of tissue macrophages, including Kupffer cells in the liver and F4/80+ macrophages of the lung, kidney, spleen and intestine. The small numbers of positive cells isolated from the liver resembled blood monocytes. In the gut, ECFP+ cells were identified primarily as classical dendritic cells or blood monocytes in disaggregated cell preparations. Immunohistochemistry showed large numbers of ECFP+ cells in the Peyer's patch and isolated lymphoid follicles. The MacBlue transgene was used to investigate the effect of treatment with CSF1-Fc, a form of the growth factor with longer half-life and efficacy. CSF1-Fc massively expanded both the immature myeloid cell (ECFP−) and Ly6C+ monocyte populations, but had a smaller effect on Ly6C− monocytes. There were proportional increases in ECFP+ cells detected in lung and liver, consistent with monocyte infiltration, but no generation of ECFP+ Kupffer cells. In the gut, there was selective infiltration of large numbers of cells into the lamina propria and Peyer's patches. We discuss the use of the MacBlue transgene as a marker of monocyte/macrophage/dendritic cell differentiation.
Who is minding the kids? Preferences, choices and childcare arrangements of working mothers in India

Women's employment outside the home in developing countries has been increasing steadily over last several decades leading to unprecedented changes in family organisation including decline in family size and extended/joint family structures, which have implications for childcare needs of working mothers. However, the inter-connections between these changes, i.e., women's work, childcare arrangements and wellbeing have remained rather unexplored in the developing world. This paper is an attempt in this direction and examines the childcare arrangements, preferences and the decision-making process of working mothers of children aged 0-36 months of age in India, a country undergoing rapid modernization, urbanization and accompanying social change.
The Potential of Active Contour Models in Extracting Road Edges from Mobile Laser Scanning Data

Active contour models present a robust segmentation approach, which makes efficient use of specific information about objects in the input data rather than processing all of the data. They have been widely-used in many applications, including image segmentation, object boundary localisation, motion tracking, shape modelling, stereo matching and object reconstruction. In this paper, we investigate the potential of active contour models in extracting road edges from Mobile Laser Scanning (MLS) data. The categorisation of active contours based on their mathematical representation and implementation is discussed in detail. We discuss an integrated version in which active contour models are combined to overcome their limitations. We review various active contour-based methodologies, which have been developed to extract road features from LiDAR and digital imaging datasets. We present a case study in which an integrated version of active contour models is applied to extract road edges from MLS dataset. An accurate extraction of left and right edges from the tested road section validates the use of active contour models. The present study provides valuable insight into the potential of active contours for extracting roads from 3D LiDAR point cloud data.
ADVANCES IN EVOLUTIONARY CULTURE THEORY

In this paper, I review recent attempts to formulate an evolutionary theory of cultural change. Historically, cultural evolution has had a bad name in anthropology, largely because the term has been used to describe unilineal schemes of social development and to promote the "biologicization" of the discipline. When defined and used appropriately, however, the term deserves a better fate. I argue that the conceptual systems we call cultures do evolve in the important, specific sense of "descent with modification," and that anthropology cannot afford to deny or ignore this fact. On the contrary, I suggest that there is much to be gained by adding an evolutionary perspective of this kind to cultural theory and analysis. The last decade has witnessed a number of pioneering efforts in this direction; here I review five of the leading theoretical formulations, pointing out their similarities, differences, and specific contributions to the evolving subfield of evolutionary culture theory.
The role of haploinsufficiency of RPS14 and p53 activation in the molecular pathogenesis of the 5q- syndrome

In recent years we have gained great insight into the molecular pathogenesis of the 5q- syndrome, a distinct subtype of myelodysplasia. The demonstration of haploinsufficiency of the ribosomal gene RPS14 (mapping to the commonly deleted region) and the finding that this is the cause of the erythroid defect in the 5qsyndrome represent major advances. A mouse model of the human 5q- syndrome generated by large-scale deletion of the Cd74-Nid67 interval (containing RPS14) further supports a critical role for RPS14 haploinsufficiency. It is widely accepted that ribosomal deficiency results in p53 activation and defective erythropoiesis and the crossing of the ‘5q- mice’ with p53 deficient mice ameliorated the erythroid progenitor defect. Emerging data suggests that the p53 activation observed in the mouse model may also apply to the human 5q- syndrome.
Ovarian Production of Estrogens in Postmenopausal Women

We investigated the possible secretory capacity of the ovaries of 79 postmenopausal women with and without endometrial carcinoma using chemical, enzymehistochemical and ultrastructural methods. The mean serum levels of estrone, estradiol and total estrogens were higher in ovarian effluent blood than the corresponding values in cubital venous blood. There was a positive correlation between the difference of total estrogens in ovarian and cubital vein sera and, on the other hand, enzymehistochemical and ultrastructural findings in ovarian tissue. No statistical differences were found in the peripheral mean values of estrone and total estrogens between the two groups. The mean level of estradiol, however, seemed to be higher and that of estriol lower in the carcinoma patients than in the control groups.
Vaccination against pandemic A/H1N1 2009 influenza in pregnancy and risk of fetal death: cohort study in Denmark

Objective To investigate whether an adjuvanted pandemic A/H1N1 2009 influenza vaccine in pregnancy was associated with an increased risk of fetal death. Design Nationwide register based cohort study. Setting Denmark. Participants All clinically recognised singleton pregnancies that ended between November 2009 and September 2010. Individual level data on exposure to an inactivated AS03 pandemic A/H1N1 2009 influenza vaccine (Pandemrix) and potential confounders were linked to the study cohort using a unique person identifier. Main outcome measures The primary outcome measure was risk of fetal death (spontaneous abortion and stillbirth combined) in H1N1 vaccinated compared with unvaccinated pregnancies, adjusting for propensity scores. Secondary outcome measures were spontaneous abortion (between seven and 22 weeks’ gestation) and stillbirth (after 22 completed weeks’ gestation). Results The cohort comprised 54 585 pregnancies; 7062 (12.9%) women were vaccinated against pandemic A/H1N1 2009 influenza during pregnancy. Overall, 1818 fetal deaths occurred (1678 spontaneous abortions and 140 stillbirths). Exposure to the H1N1 vaccine was not associated with an increased risk of fetal death (adjusted hazard ratio 0.79, 95% confidence interval 0.53 to 1.16), or the secondary outcomes of spontaneous abortion (1.11, 0.71 to 1.73) and stillbirth (0.44, 0.20 to 0.94). Estimates for fetal death were similar in pregnant women with (0.82, 0.44 to 1.53) and without comorbidities (0.77, 0.47 to 1.25). Conclusion This large cohort study found no evidence of an increased risk of fetal death associated with exposure to an adjuvanted pandemic A/H1N1 2009 influenza vaccine during pregnancy.
Light subgraphs of graphs embedded in the plane and in the projective plane – a survey –

It is well known that every planar graph contains a vertex of degree at most 5. A theorem of Kotzig states that every 3-connected planar graph contains an edge whose endvertices have degree-sum at most 13. Recently, Fabrici and Jendrol’ proved that every 3-connected planar graph G that contains a k-vertex path, a path on k vertices, contains also a k-vertex path P such that every vertex of P has degree at most 5k. A result by Enomoto and Ota says that every 3-connected planar graph G of order at least k contains a connected subgraph H of order k such that the degree sum of vertices of H in G is at most 8k− 1. Motivated by these results, a concept of light graphs has been introduced. A graph H is said to be light in a family G of graphs if at least one member of G contains a copy of H and there is an integer w(H,G) such that each member G of G with a copy of H also has a copy K of H with degree sum ∑ v∈V (K) degG(v) ≤ w(H,G). In this paper we present a survey of results on light graphs in different families of plane and projective plane graphs and multigraphs. A similar survey dealing with the family of all graphs embedded in surfaces other than the sphere and the projective plane was prepared as well.
Towards a valid and reliable measure of visitor satisfaction

This article presents an empirical study into the development of a multi-item visitor satisfaction scale. The article reviews existing measures from consumer behaviour and tourism research and highlights an absence in the inclusion of emotional and dissonance related items. A research question is specified and a methodology discussed identifying the stages in the development of this scale. Results support a need for a better understanding of emotion and dissonance within visitor satisfaction measures and consequently in the development of tourism destination marketing strategies.
Visual rating of white matter hyperintensities in Parkinson's disease

Dementia is a common complication of Parkinson's disease (PD), but the cause is incompletely understood. In previous studies, dementia has been associated with an increase in hyperintense lesions in the cerebral white matter. The aim of this study was to explore whether white matter hyperintensities (WMH) on cerebral magnetic resonance imaging (MRI) are associated with dementia in PD. For this study, 35 patients with PD, 16 with dementia (PDD) and 19 without (PDND), and 20 control subjects were recruited. MRI scans of patients and controls were rated for WMH, blind to diagnosis, using the Scheltens visual rating scale. Both bivariate and multivariate statistical analyses were carried out. Cerebrovascular risk factors, education, gender, or age were similar across groups. Compared with the PDND group, the PDD group had significantly higher level of WMH in the deep white matter and in the periventricular areas. WMH in the deep white matter was the only variable that was associated significantly with Mini‐Mental State Examination score and explained 38% of the variance in the multivariate linear regression analysis. Our findings suggest that WMH in the deep white matter may contribute to dementia in PD. © 2005 Movement Disorder Society
Isoflurane Differentially Affects Neurogenesis and Long-term Neurocognitive Function in 60-day-old and 7-day-old Rats

Background:Anesthetic agents cause cell death in the developing rodent brain and long-term, mostly hippocampal-dependent, neurocognitive dysfunction. However, a causal link between these findings has not been shown. Postnatal hippocampal neurogenesis affects hippocampal function into adulthood; therefore, the authors tested the hypothesis that isoflurane affects long-term neurocognitive function via an effect on dentate gyrus neurogenesis. Methods:The S-phase marker 5-bromodeoxyuridine was administered at various times before, during, and after 4 h of isoflurane given to postnatal day (P)60 and P7 rats to assess dentate gyrus progenitor proliferation, early neuronal lineage selection, and long-term survival of new granule cell neurons. Fear conditioning and spatial reference memory was tested at various intervals from 2 weeks until 8 months after anesthesia. Results:In P60 rats, isoflurane increased early neuronal differentiation as assessed by BrdU/NeuroD costaining, decreased progenitor proliferation for 1 day, and subsequently increased progenitor proliferation 5–10 days after anesthesia. In P7 rats, isoflurane did not induce neuronal lineage selection but decreased progenitor proliferation until at least 5 days after anesthesia. Isoflurane improved spatial reference memory of P60 rats long-term, but it caused a delayed-onset, progressive, persistent hippocampal deficit in P7 rats in fear conditioning and spatial reference memory tasks. Conclusion:The authors conclude that isoflurane differentially affects both neurogenesis and long-term neurocognitive function in P60 and P7 rats. Neurogenesis might mediate the long-term neurocognitive outcome after isoflurane at different ages.
Employment grade differences in cause specific mortality. A 25 year follow up of civil servants from the first Whitehall study

STUDY OBJECTIVE To test the hypothesis that the association between socioeconomic status and mortality rates cuts across the major causes of death for middle aged and elderly men. DESIGN 25 year follow up of mortality in relation to employment grade. SETTING The first Whitehall study. PARTICIPANTS 18 001 male civil servants aged 40–69 years who attended the initial screening between 1967 and 1970 and were followed up for at least 25 years. MAIN OUTCOME MEASURE Specific causes of death. RESULTS After more than 25 years of follow up of civil servants, aged 40–69 years at entry to the study, employment grade differences still exist in total mortality and for nearly all specific causes of death. Main risk factors (cholesterol, smoking, systolic blood pressure, glucose intolerance and diabetes) could only explain one third of this gradient. Comparing the older retired group with the younger pre-retirement group, the differentials in mortality remained but were less pronounced. The largest decline was seen for chronic bronchitis, gastrointestinal diseases and genitourinary diseases. CONCLUSIONS Differentials in mortality persist at older ages for almost all causes of death.
Genome-wide study of methotrexate clearance replicates SLCO1B1.

Methotrexate clearance can influence the cure of and toxicity in children with acute lymphoblastic leukemia (ALL). We estimated methotrexate plasma clearance for 1279 patients with ALL treated with methotrexate (24-hour infusion of a 1 g/m2 dose or 4-hour infusion of a 2 g/m2 dose) on the Children’s Oncology Group P9904 and P9905 protocols. Methotrexate clearance was lower in older children (P = 7 x 10(-7)), girls (P = 2.7 x 10(-4)), and those who received a delayed-intensification phase (P = .0022). A genome-wide analysis showed that methotrexate clearance was associated with polymorphisms in the organic anion transporter gene SLCO1B1 (P = 2.1 x 10(-11)). This replicates findings using different schedules of high-dose methotrexate in St Jude ALL treatment protocols; a combined meta-analysis yields a P value of 5.7 x 10(-19) for the association of methotrexate clearance with SLCO1B1 SNP rs4149056. Validation of this variant with 5 different treatment regimens of methotrexate solidifies the robustness of this pharmacogenomic determinant of methotrexate clearance. This study is registered at http://www.clinicaltrials. gov as NCT00005585 and NCT00005596.