Miracle-dz/UniFAR-FTUs huggingface dataset:
The Feasibility of Brute Force Scans for Real-Time Tweet Search

The real-time search problem requires making ingested documents immediately searchable, which presents architectural challenges for systems built around inverted indexing. In this paper, we explore a radical proposition: What if we abandon document inversion and instead adopt an architecture based on brute force scans of document representations? In such a design, "indexing" simply involves appending the parsed representation of an ingested document to an existing buffer, which is simple and fast. Quite surprisingly, experiments with TREC Microblog test collections show that query evaluation with brute force scans is feasible and performance compares favorably to a traditional search architecture based on an inverted index, especially if we take advantage of vectorized SIMD instructions and multiple cores in modern processor architectures. We believe that such a novel design is worth further exploration by IR researchers and practitioners.
Space-time MIMO multicasting

Multicasting is the general method of conveying the same information to multiple users over a broadcast channel. In this work, the Gaussian MIMO broadcast channel is considered, with multiple users and any number of antennas at each node. A “closed loop” scenario is assumed, for which a practical capacity-achieving multicast scheme is constructed. In the proposed scheme, linear modulation is carried over time and space together, which allows to transform the problem into that of transmission over parallel scalar sub-channels, the gains of which are equal, except for a fraction of sub-channels that vanishes with the number of time slots used. Over these sub-channels, off-the-shelf fixed-rate AWGN codes can be used to approach capacity.
Male-mediated developmental toxicity

Male-mediated developmental toxicity has been of concern for many years. The public became aware of male-mediated developmental toxicity in the early 1990s when it was reported that men working at Sellafield might be causing leukemia in their children. Human and animal studies have contributed to our current understanding of male-mediated effects. Animal studies in the 1980s and 1990s suggested that genetic damage after radiation and chemical exposure might be transmitted to offspring. With the increasing understanding that there is histone retention and modification, protamine incorporation into the chromatin and DNA methylation in mature sperm and that spermatozoal RNA transcripts can play important roles in the epigenetic state of sperm, heritable studies began to be viewed differently. Recent reports using molecular approaches have demonstrated that DNA damage can be transmitted to babies from smoking fathers, and expanded simple tandem repeats minisatellite mutations were found in the germline of fathers who were exposed to radiation from the Chernobyl nuclear power plant disaster. In epidemiological studies, it is possible to clarify whether damage is transmitted to the sons after exposure of the fathers. Paternally transmitted damage to the offspring is now recognized as a complex issue with genetic as well as epigenetic components.
Effects of attitudinal and sociodemographic factors on pro-environmental behaviour in urban China

SUMMARY China currently faces severe environmental challenges, and information regarding the predictors of pro-environmental behaviour in China is needed to manage them. This study addresses this need by modelling the sociodemographic and attitudinal factors predicting pro-environmental behaviour in urban China. Pro-environmental behaviour was modelled as a function of environmental attitude (measured using the new environmental paradigm) and various sociodemographic characteristics. Respondents who were employed, holding leadership positions, living in larger cities and single were more likely to participate in pro-environmental behaviour. These results accord with previous studies suggesting being female, younger, highly educated and having environmentally oriented attitudes increased the odds of participating in pro-environmental behaviour. The rapid urbanization and economic development in China may significantly impact pro-environmental behaviour in the future.
Smoking,alcohol and tea drinking on Alzheimer's disease

Objectives To investigate the risk of Alzheimer's disease (AD) associated with smoking,tea-drinking and alcohol-drinking.Methods We conducted a population based,m∶n matched case-control study on 402 AD patients,and 384 controls matched for age,sex and education. Univariate and multivariate analysis was conducted using conditional Logistic model. Cross analysis was conducted between smoking and vascular events.Results In multivariate analysis ,the OR (odds ratio) was 0.757 for individuals over 50 years old regular tea drinking 1-3 times per month compared with those less than once per month( P =0.0001). And the OR for AD decreased as the frequency of tea-drinking was increased. The OR was 0.4338 for those who drink tea almost everyday. Compared with those who didn't smoke over 50 years old,the OR was 0.769 for 0.1～9.9 pack-year smokers( P =0.0602). While the OR for those who smoked over 10 pack-year was 0.5914 . There were negative cross effects between smoking and vascular events. There was no relation between alcohol-drinking and AD. Conclusion This preliminary case-control study suggests that the regular tea-drinking may be the protective factors of AD. Smoking might reduce the risk of AD by itself and increase the risk of AD through the effect of vascular events. There should be dose-response association between regular tea-drinking or smoking and AD. The study might also benefit to the therapy and prevention of AD.
Ten-Year Prognosis of Stroke and Risk Factors for Death in a Japanese Community: The Hisayama Study

Background and Purpose— There have been very few population-based cohort studies of long-term prognosis and risk factors for death after stroke. We examined the 10-year prognosis, causes, and risk factors of death after stroke in a Japanese cohort. Methods— During a 26-year follow-up of a cohort of 1621 subjects ≥40 years of age, 333 subjects developed first-ever stroke and were prospectively followed up for 10 years after onset. During these 10-year follow-up periods, 268 of the 333 stroke patients died. Of those, 239 (89.2%) underwent autopsy. Results— The risk of death was greatest in the first year after first-stroke onset in both sexes (men, 40.3%; women, 43.7%). Thereafter, the survival curves decreased gradually, and risk of death reached 80.7% for men and 80.2% for women by the end of the 10-year follow-up. The 30-day case fatality rate was substantially greater in patients with cerebral hemorrhage (63.3%) or subarachnoid hemorrhage (58.6%) than in patients with cerebral infarction (9.0%). The risk of dying after the first stroke was twice the risk for stroke-free subjects. The most common cause of death was the index stroke in the first year. Thereafter, the impact of the first stroke gradually decreased, while that of recurrent stroke increased. Multivariate analysis revealed that age, lower body mass index, and hemorrhagic stroke were significant risk factors for death after stroke. Conclusions— Our findings suggest that the risk of death after first-ever stroke is high, in part because of the larger proportion of hemorrhagic stroke in Japanese relative to stroke victims in Western countries.
Relationship between probiotic consumption and IL-10 and IL-17 secreted by PBMCs in overweight and obese people.

1 Department of Nutrition, Tehran University of Medical Sciences, Tehran, Iran 2 Department of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran 3 Department of Food Sciences and School of Medicine, Tehran University of Medical Sciences, Tehran, Iran 4 Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 5 Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
Security Estimation Model for Military Aircrafts Using Directional Antennas

In the real military scenarios and particularly using Unmanned Aerial Vehicles (UAVs) that perform aspecific communication task; it is not desirable to have an antenna that covers a wide angle. Omni directional antenna transmits power into all directions and thus it gives transmitter benefits of increasing the probability of being detected by hostile receivers. This paper addresses the problem by exploring the security advantagesof using directional antennas in the battlefield. In this respect, we considered a collection of military UAVs that communicates through a wireless link and forms a Mobile AdHoc Network (MANET) using directionalantenna. We develop a security estimation model for each UAV that is capable for calculating the probability of detecting any transmitter in its range. With this model, each UAV can determine the total area in which the probability of detecting hostile transmitter is bigger than zero. Transmission between UAVs will be established using directional antenna that is able to form a directional beam pointing to anyreceiver locatedoutside the previous area. The results of the Optimized Network Engineering Tool (OPNET) simulator indicatesan overall improvement in security level of directional transmission over Omni directional transmission.
Blood Lead Concentrations < 10 μg/dL and Child Intelligence at 6 Years of Age

Background Few studies provide data directly relevant to the question of whether blood lead concentrations < 10 μg/dL adversely affect children’s cognitive function. Objective We examined the association between blood lead concentrations assessed throughout early childhood and children’s IQ at 6 years of age. Methods Children were followed from 6 months to 6 years of age, with determination of blood lead concentrations at 6, 12, 18, and 24 months, and 3, 4, 5, and 6 years of age. At 6 years of age, intelligence was assessed in 194 children using the Wechsler Preschool and Primary Scale of Intelligence–Revised. We used general linear and semiparametic models to estimate and test the association between blood lead concentration and IQ. Results After adjustment for maternal IQ, HOME scale scores, and other potential confounding factors, lifetime average blood lead concentration (mean = 7.2 μg/dL; median = 6.2 μg/dL) was inversely associated with Full-Scale IQ (p = 0.006) and Performance IQ scores (p = 0.002). Compared with children who had lifetime average blood lead concentrations < 5 μg/dL, children with lifetime average concentrations between 5 and 9.9 μg/dL scored 4.9 points lower on Full-Scale IQ (91.3 vs. 86.4, p = 0.03). Nonlinear modeling of the peak blood lead concentration revealed an inverse association (p = 0.003) between peak blood lead levels and Full-Scale IQ down to 2.1 μg/dL, the lowest observed peak blood lead concentration in our study. Conclusions Evidence from this cohort indicates that children’s intellectual functioning at 6 years of age is impaired by blood lead concentrations well below 10 μg/dL, the Centers for Disease Control and Prevention definition of an elevated blood lead level.
Automated Memory Allocation of Actor Code and Data Buffer in Heterochronous Dataflow Models to Scratchpad Memory

Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. To copy otherwise, to republish, to post on servers or to redistribute to lists, requires prior specific permission. Abstract A scratchpad memory is a fast compiler-managed on-chip memory that replaces the hardware managed cache in several embedded processors. Scratchpad memories provide better real-time guarantees, and significantly lower overheads in energy consumption and area as compared to caches [9]. Several allocation schemes exist for mapping variables, data and code to the scratchpad memory. However, none of these schemes seek to optimize the allocation based on the control flow and data flow information that can be gleaned from block diagram based programs in frameworks in LabVIEW and Ptolemy II [7]. In this report we present methods for scratchpad memory allocation of block diagram programs composed under the Heterochronous Dataflow (HDF) model of computation [3]. HDF is a heterogeneous composition of Synchronous Dataflow (SDF) [1] and Finite State Machines (FSM). It is significantly more expressive than SDF since it allows rate changes in actors during execution. The memory allocation method exploits the coarse grained software architecture and semantics of the HDF models to gather information about the temporal pattern and access frequencies of memory references and the memory requirements of the computational blocks. This information is processed using an Integer Linear Program (ILP) based framework to generate the optimal memory allocation for each state in the HDF graph. We also present a modified version of the algorithm which generates multiple allocations for each state. The ILP based allocation algorithm is shown to perform significantly better than caches. We also show that the allocation algorithm increases predictability by being completely independent of the scheduling technique used to generate the execution 3 schedule for the HDF model. The algorithmic modification that generates multiple allocations per state is shown to perform better than the original algorithm for actor code allocation for intermediate scratchpad sizes. We present a strict upper bound on the memory access time of a HDF model allocated to scratchpad using the above algorithm. We also present several interesting directions for future exploration. 4 Acknowledgements This work is the culmination of eighteen years of …
A Structural Model for Vinculin Insertion into PIP 2-ContainingMembranes and the Effect of Insertion on Vinculin Activation and Localization Graphical Abstract Highlights

Graphical Abstract Highlights d The vinculin tail contains two basic patches with distinct lipid binding roles d The basic collar recognizes PIP 2 d The basic ladder recognizes acidic phospholipids d Lipid binding increases vinculin activation and turnover at focal adhesions In Brief Vinculin is a cytoskeletal protein that controls cellular adhesion and migration. Thompson et al. show that two basic patches on the tail domain cooperate to bind lipid membranes containing PIP 2. These binding events regulate vinculin activation and turnover at focal adhesions. SUMMARY Vinculin, a scaffolding protein that localizes to focal adhesions (FAs) and adherens junctions, links the actin cytoskeleton to the adhesive superstructure. While vinculin binds to a number of cytoskeletal proteins , it can also associate with phosphatidylinositol 4,5-bisphosphate (PIP 2) to drive membrane association. To generate a structural model for PIP 2-dependent interaction of vinculin with the lipid bilayer, we conducted lipid-association, nuclear magnetic resonance , and computational modeling experiments. We find that two basic patches on the vinculin tail drive membrane association: the basic collar specifically recognizes PIP 2 , while the basic ladder drives association with the lipid bilayer. Vinculin mutants with defects in PIP 2-dependent liposome association were then expressed in vinculin knockout murine embryonic fibroblasts. Results from these analyses indicate that PIP 2 binding is not required for localiza-tion of vinculin to FAs or FA strengthening, but is required for vinculin activation and turnover at FAs to promote its association with the force transduc-tion FA nanodomain.
Big Data Provenance Analysis and Visualization

Provenance captured from E-Science experimentation is often large and complex, for instance, from agent-based simulations that have tens of thousands of heterogeneous components interacting over extended time periods. The subject of study of my dissertation is the use of E-Science provenance at scale. My initial research studied the visualization of large provenance graphs and proposed an abstract representation of provenance that supports useful data mining. Recent work involves analyzing large provenance data generated from agent-based simulations on a single machine. In continuation, I propose stream processing techniques to support the continuous and real-time analysis of data provenance, which is captured from agent based simulations on HPC and thus has unprecedented volume and complexity.
The Tits alternative for Out(Fn) II: A Kolchin type theorem

The proof of the Tits alternative for $Out(F_n)$ is completed. The main tool is a Kolchin type theorem, proved in this paper. It states that a finitely generated subgroup of $Out(F_n)$ consisting of unipotent automorphisms can be conjugated into an upper-triangular subgroup (this is interpreted via train-tracks).
The Development of a Canine Para-Agility Program: Positive Affects in Children with Autism and in Therapy Dogs

Previous research has demonstrated that both children and dogs might benefir from Animal-Assisted Activities (AAA), with some factors mediating/ moderating the results. The present study took these factors into consideration, by creating an AAA program consisting of two types of human-animal interactions (structured and unstructured activities), with an accent being put on the encouragement of positive behaviors. Differences in the frequency of behavioral indicators of positive affects were compared between sessions, in both species (humans and dogs). The preliminary analysis of the results indicated no significant differences between the structured and unstructured sessions in regards of the behavioral indicators of positive affects in humans and dogs, concluding that children and dogs enjoyed the activities in both types of sessions. A more in depth statistical analysis is currently being performed.
Genetic Features of Metachronous Esophageal Cancer Developed in Hodgkin’s Lymphoma or Breast Cancer Long-Term Survivors: An Exploratory Study

Background Development of novel therapeutic drugs and regimens for cancer treatment has led to improvements in patient long-term survival. This success has, however, been accompanied by the increased occurrence of second primary cancers. Indeed, patients who received regional radiotherapy for Hodgkin’s Lymphoma (HL) or breast cancer may develop, many years later, a solid metachronous tumor in the irradiated field. Despite extensive epidemiological studies, little information is available on the genetic changes involved in the pathogenesis of these solid therapy-related neoplasms. Methods Using microsatellite markers located in 7 chromosomal regions frequently deleted in sporadic esophageal cancer, we investigated loss of heterozygosity (LOH) and microsatellite instability (MSI) in 46 paired (normal and tumor) samples. Twenty samples were of esophageal carcinoma developed in HL or breast cancer long-term survivors: 14 squamous cell carcinomas (ESCC) and 6 adenocarcinomas (EADC), while 26 samples, used as control, were of sporadic esophageal cancer (15 ESCC and 11 EADC). Results We found that, though the overall LOH frequency at the studied chromosomal regions was similar among metachronous and sporadic tumors, the latter exhibited a statistically different higher LOH frequency at 17q21.31 (p = 0.018). By stratifying for tumor histotype we observed that LOH at 3p24.1, 5q11.2 and 9p21.3 were more frequent in ESCC than in EADC suggesting a different role of the genetic determinants located nearby these regions in the development of the two esophageal cancer histotypes. Conclusions Altogether, our results strengthen the genetic diversity among ESCC and EADC whether they occurred spontaneously or after therapeutic treatments. The presence of histotype-specific alterations in esophageal carcinoma arisen in HL or breast cancer long-term survivors suggests that their transformation process, though the putative different etiological origin, may retrace sporadic ESCC and EADC carcinogenesis.
Visualization for University Brand Image Clustering by Simple Topic Model

Bayesian inference is widely used in various application fields such as topic extraction. In the paper, we present our developed simple topic model visualization tool and as its example, we show university brand image clustering. When high school students select a university, their university choice greatly depends on their universities' brand images. Then the university public relations section needs the survey of the brand images. The clustering results is so helpful for the public relations section to make the publicity strategy. We conducted the university clustering with our developed visualization tool. The paper shows that the visualization has great potential to identify whether the Markov chain reaches the equilibrium states and evaluate the burn-in period.
Correlation between new media literacy and media exposure: Towards media convergence and diversification

The exponential growth of new media and technology has resulted in an increased presence of media in the lives of average individuals: as a source of information and a means of communication, learning, and entertainment. Media exposure therefore becomes an important factor in shaping the modern man; however, this raises the question whether the increased possibility of media consumption also results in the development of man's media literacy. The aim of this paper is to examine the dependence of new media competencies of the Serbian academic community on their exposure to the media (television, print media, the Internet, and video games). An interesting aspect of this study is that the results of a correlation between new media literacy and media exposure obtained among Serbian academic population do not significantly differ from the results of similar studies in different political, cultural, economic, and social conditions. Therefore, there is the impression that the dilemmas of media competencies and convergent and participatory media cultures reflect the trends and objectives of globalization. The results also explicitly point to the current problem of media diversity, which is posed in theory and materialized in practice, as well as to the fact that the necessary convergence of old and new media for shaping the media-competent individual has not been achieved.
Combining OOK with PSM Modulation for Simple Transceiver of Orthogonal Pulse-Based TH-UWB Systems

This paper describes a combined modulation scheme for time-hopping ultra-wideband (TH-UWB) radio systems by using on-off keying (OOK) and pulse-shape modulation (PSM). A set of orthogonal pulses is used to represent bits in a symbol. These orthogonal pulses are transmitted simultaneously in the same pulse repetition interval resulting in a composite pulse. This scheme transmits the same number of bits by using fewer orthogonal pulses and receiver correlators than those used in PSM and biorthogonal PSM (BPSM). The proposed scheme reduces multiple-access interference and multipulse interference considerably by using crosscorrelation properties of orthogonal pulses. Since each bit is individually received by OOK, the proposed scheme requires less power. Hence, it is applicable for energy constrained and low-cost TH-UWB systems. The bit-error-rate (BER) performance is analyzed both mathematically and through computer simulations under the different channel environments. The performance of this scheme is compared with that of existing PSM and its combined modulation schemes by using two sets of orthogonal pulses.