Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploiting the distributed foreground memory in coarse grain reconfigurable arrays for reducing the memory bottleneck in DSP applications

This paper presents a methodology for memory-aware mapping on 2-Dimensional coarse-grained reconfigurable architectures that aims in the minimization of the data memory accesses for DSP and multimedia applications. Additionally, the realistic 2-Dimensional coarse-grained reconfigurable architecture template to which the mapping methodology targets, models a large number of existing coarse-grained architectures. This is exploited for quantifiyng the influnce that the architectural features have on performance improvements achieved by our methodology. A novel mapping algorithm is also proposed that uses a list scheduling technique in which the binding, routing, and scheduling phases are considered together and they are steered by a set of costs. The algorithm transfers the data reuse values in the internal interconnection network instead of being fetched in order to reduce the data transfer burden on the bus network. The experimental results show that memory accesses and execution time are reduced since the mapping methodology efficiently exploits the data reuse opportunities.
BrightBrainer feasibility study in a medical adult day program

Purpose: To determine the feasibility of BrightBrainer training of elderly with dementia attending a Medical Adult Day Program. Method: BrightBrainer brain training games were played by 10 participants who sat in front of a projector screen and interacted through a bimanual game controller. The custom games targeted several cognitive domains such as focus, problem solving, short term memory, working memory, and language comprehension. Participants had a choice of what games to play among those available, and the difficulty adjusted automatically based on individual past performance. The system underwent feasibility trials spanning 16 sessions over 8 weeks. Participants were evaluated pre-intervention, post-intervention, and at 8 week follow up using standardized neuropsychological measures. Computerized measures of movement repetitions, task performance, session duration, games played and game scores were stored on a remote server. Results: Group analysis showed improvement in the cognitive domain of 1.4 points on Mini Mental Status Exam (MMSE) between pre-training and follow-up. One participant who started with MC1 ended with normal cognition (max scores on MMSE and Brief Interview of Mental Status - BIMS). Caregiver feedback noted participants' increased ability to follow one-step directions, to perform activities of daily living and increased desire to attend the Adult Day Program. Most participants enjoyed the computerized training.
The two‐thirds power law in motion perception

If a visual motion abruptly vanishes, the vanishing point is mislocalized in the anticipated direction of the motion (cf. Freyd & Finke, 1984; Hubbard & Bharucha, 1988; Verfaillie & d'Ydewalle, 1991). Here, we replicate this effect for curvilinear motions, showing that the compatibility with human movements, as expressed by the two‐thirds power law (cf. Lacquaniti, Terzuolo, & Viviani, 1983; Viviani, 2002), specifically contribute to this anticipation error. Thus, the compatibility effect does not manifest itself solely in an overshooting of the judged vanishing position in comparison to the objective vanishing position, but also in a more accurate anticipation of the curvilinearity of the forthcoming motion. The latter effect only occurred for spatially unpredictable target motions. Spatially more predictable target motions allowed for a different kind of anticipation, which overrode the compatibility effect. The results are discussed with regard to the notion of an action‐related influence on motion perception.
Economic value of health Valor econômico da saúde

The Serviço Especial de Saúde Pública, created on July 17, 1942 by virtue of the contract between the Governments of the United States of Brazil and of the United States of America, signed respectively by the Ministry of Health and Education to which it is subordinated, and the Institute of Inter-American Affairs, is maintained on a cooperative basis by the governments of booths countries. ETPAR 1952 Acknowledgements
STUDI KASUS MENGENAI SUBJECTIVE WELL-BEING PADA REMAJA DALAM MASA EMERGING ADULTHOOD YANG ORANG TUANYA BERCERAI

Penelitian ini dilaksanakan untuk memperoleh gambaran dinamika subjective well-being pada remaja dalam masa emerging adulthood yang orang tuanya bercerai. Rancangan yang digunakan adalah studi kasus. Penelitian ini menggunakan dua kasus, dengan karakteristik bahwa perceraian orang tua terjadiketika remaja berada pada rentang usia sekolah dasar. Pengumpulan data dilakukan dengan menggunakan metode wawancara secara mendalam. Kerangka wawancara dibuat oleh peneliti berdasarkan teori subjective well-being dari Ed Diener dan Robert Biswas-Diener (2008). Kredibilitas dari penelitian ini ditingkatkan dengan menggunakan triangulasi data. Berdasarkan hasil pengolahan data dengan menggunakan mixed methods content analysis, diperoleh gambaran dinamika subjective well-being dilihat dari aspek dan faktor yang memengaruhinya. Kesimpulan yang diperoleh dari penelitian adalah bahwa saat ini remaja dalam masa emerging adulthood yang orang tuanya bercerai dapat dikatakan cenderung bahagia (subjective well-being). Agama, pendapatan, relasi sosial, dan tujuan hidup merupakan faktor penting yang memengaruhi tercapainya subjective well-being. Peneliti mengajukan saran agar peneliti selanjutnya melakukan penelitian kepada subjek dengan jenis kelamin yang berbeda. Kata-kata kunci: Subjective well-being, remaja emerging adulthood, orang tuanya bercerai This research is a case study concerning subjective well-being in adolescents in the period of emerging adulthood whose parents were divorced. The purpose of this research is to obtain the dynamic of subjective well-being in adolescents in the period of emerging adulthood whose parents were divorced. This research used two cases, with characteristic that parental divorce occurred when adolescents were in primary school. The data is obtained by using in-depth interview. Framework interview is made by researcher using subjective well -being theory by Ed Diener and Robert Biswas-Diener (2008). Credibility of this research is improved by using data triangulation. Based on data analysis using mixed methods content analysis, researcher obtains the picture of the dynamic of subjective well-being from the aspects and influencial factors. Conclusion from this research is adolescents in the period of emerging adulthood whose parents were divorced tend to be happy (subjective well-being). Religion, income, social relations, and the purpose of life are important factors that influence the achievement of subjective wellbeing. Suggestion for the next researcher is to use a different gender as their subject of research. Keywords: Subjective well-being, adolescents in emerging adulthood, divorced parents
Anxious depression and early changes in the HAMD-17 anxiety-somatization factor items and antidepressant treatment outcome

The objective of this study was to assess the relationship between early changes in anxiety/somatization symptoms and treatment outcome among major depressive disorder patients during a 12-week trial of fluoxetine. We also examined the relationship between anxious depression and treatment response. Five hundred and ten major depressive disorder patients received 12 weeks of fluoxetine with flexible dosing [target dosages: 10 mg/day (week 1), 20 mg/day (weeks 2–4), 40 mg/day (weeks 4–8), and 60 mg/day (weeks 5–12)]. We assessed the relationship between early changes in 17-item Hamilton Rating Scale for Depression (HAMD-17)-anxiety/somatization factor items and depressive remission, as well as whether anxious depression at baseline predicted remission at study endpoint. Baseline HAMD-17 scores were considered as covariates and the Bonferroni correction (P≤0.008) was used for multiple comparisons. Adjusting for baseline HAMD-17 scores, patients who experienced greater early improvement in somatic symptoms (gastrointestinal) were significantly more likely to attain remission (HAMD-17 <8) at endpoint than those without early improvement (P=0.006). Early changes in the remaining items did not predict remission, nor did anxious depression at baseline. In conclusion, among the anxiety/somatization factor items, only early changes in somatic symptoms (gastrointestinal) predicted remission. Future studies are warranted to further investigate this relationship as well as that between anxious depression and treatment outcome.
Biological evaluation of Paclitaxel-peptide conjugates as a model for MMP2-targeted drug delivery

Paclitaxel (PTX) is a highly effective and cytotoxic agent widely used for the treatment of several solid tumors. However, PTX shows dose-limiting cytotoxicity and in most of the cases induces drug resistance followed by failure in treatments. To enhance the therapeutic index of a given drug, various drug delivery methods are being explored to systemically deliver sufficient amount of the drug to the desired site. In the present study, we designed and synthesized two PTX prodrugs by conjugating PTX at different sites with an octapeptide (AcGPLGIAGQ) that can be cleaved by MMP-2 at tumor sites. As a result, PTX is expected to be released in the tumor sites, absorbed by the tumor cells, and thereby inhibit the tumor growth. We evaluated the in vitro activities of the two drugs in a panel of drug-sensitive and -resistant cancer cell lines and their in vivo efficacy in a HT1080 fibrosarcoma mouse xenograft model that highly overexpress MMP2. Our in vitro results showed that the PTX-AcGPLGIAGQ conjugates inhibited cancer cell proliferation with higher activity compared with that observed for free PTX, both of which were mediated by an arrest of G2/M-phase of the cell cycle. Consistent with the in vitro results, treatment with PTX-octapeptide conjugate resulted in extensive areas of necrosis and a lower percentage of proliferating cells in xenograft tumor sections. Together, our results indicate the potential of the tumor-targeted delivery of PTX exploiting the specific recognition of MMP2 to reduce toxicity and selective killing of tumor cells.
Perceived Continuity of Occluded Visual Objects

The human visual system does not rigidly preserve the properties of the retinal image as neural signals are transmitted to higher areas of the brain Instead, it generates a representation that captures stable surface properties despite a retinal image that is often fragmented in space and time because of occlusion caused by object and observer motion The recovery of this coherent representation depends at least in part on input from an abstract representation of three-dimensional (3-D) surface layout In the two experiments reported, a stereoscopic apparent motion display was used to investigate the perceived continuity of a briefly interrupted visual object When a surface appeared in front of the object's location during the interruption, the object was more likely to be perceived as persisting through the interruption (behind an occluder) than when the surface appeared behind the object's location under otherwise identical stimulus conditions The results reveal the influence of 3-D surface-based representations even in very simple visual tasks
3D Free-Form Object Recognition Using Indexing by Contour Features

We address the problem of recognizing free-form 3D objects from a single 2D intensity image. A model-based solution within the alignment paradigm is presented which involves three major schemes? modeling, matching, and indexing. The modeling scheme constructs a set of model aspects which can predict the object contour as seen from any viewpoint. The matching scheme aligns the edgemap of a candidate model to the observed edgemap using an initial approximate pose. The major contribution of this paper involves the indexing scheme and its integration with modeling and matching to perform recognition. Indexing generates hypotheses specifying both candidate model aspects and approximate pose and scale. Hypotheses are ordered by likelihood based on prior knowledge of pre-stored models and the visual evidence from the observed objects. A prototype implementation has been tested in recognition and localization experiments with a database containing 658 model aspects from twenty 3D objects and eighty 2D objects. Bench tests and simulations show that many kinds of objects can be handled accurately and efficiently even in cluttered scenes. We conclude that the proposed recognition-by-alignment paradigm is a viable approach to many 3D object recognition problems.
PROCEEDINGSof theHUMANFACTORSANDERGONOMICSOCIETY45thANNUALMEETING-2001 RESPONDING TO UNCERTAINTY: INDIVIDUAL DIFFERENCES AND TRAINING EFFECTS

Studiesof decisionmakingrevealindividual differences, notjustin perception, memory, categorization, and othercognitiveskillsthatsupport judgment, butalsoin themetacognitive processesthatmonitorconfidence anduncertainty. Twoexperiments aredescribedinthepresentreportinwhichapsyehophysical uncertainty taskwasusedtoassesstheseindividual differences, theirrelationtopersonalityandtemperament differences, andthepossibilityof improving howoptimallypeoplerespondto theirownuncertainty.
Hiv/aids -research and Palliative Care Dovepress Assessment of Adherence to Highly Active Antiretroviral Therapy and Associated Factors among People Living with Hiv at Debrebrihan Referral Hospital and Health Center, Northeast Ethiopia: a Cross-sectional Study

Patient adherence to antiretroviral combination therapy is a critical component to successful treatment outcome. Nonadherence to antiretroviral therapy (ART) is a major challenge to AIDS care, and the risks associated with it are extensive. The intention of this study was to determine prevalence and associated factors with adherence to highly active ART among people living with HIV/AIDS (PLWHA) at the Debrebrihan Referral Hospital and Health Center, Northeast Ethiopia. A cross-sectional study design with systematic random sampling conducted by the use of a structured, pretested self-rating adherence questionnaire was used to conduct the study among 422 respondents from the Debrebrihan Referral Hospital and Health Center. A single population proportion formula at 95% CI with 5% of marginal error at 50% of prevalence of occurrence was used to determine sample size. Adherence was defined as not missing a single ART dose during the 30-day period prior to filling out the self-report. Adherence was measured by self-reports by the patients. These results were then used in binary logistic regression analysis. Covariates were analyzed by bivariate and multivariate logistic regression with SPSS statistical software. The total number of respondents in this study was 422; their median age was 35 years. Among the participants, 95.5% were taking their medication without missing a dose. Factors such as having emotional or practical support positively encouraged ART adherence (adjusted odds ratio 0.16 [95% CI 0.05–0.49]). However, users of traditional, complementary, and alternative medicine (TCAM) (adjusted odds ratio 4.7 [95% CI 1.06–21.22]) had nearly a five times higher risk for ART nonadherence (P,0.05) than those not using TCAM. Adherence to ART among PLWA is imperative and standard. But, there is still a need to boost psychological support and practical support for the clients, and there is also a need to create a more integra-tive approach with TCAM in order to increase adherence to ART. Strengthening emotional and practical support for PLWHA and integrating TCAM with the proper use of ART are mandatory to enhance ART adherence.
Direct Reference, Empty Names and Implicature

Angle Grinder Man removes wheel locks from cars in London. He is something of a folk hero, saving drivers from enormous parking and towing fines, and has succeeded thus far in eluding the authorities. In spite of his cape and lamé tights, he is no fiction; he's a real person. By contrast, Pegasus, Zeus and the like are fictions. None of them is real. In fact, not only is each of them different from the others, all differ from Angle Grinder Man. After all, Zeus throws thunderbolts but doesn't remove boots from cars; unlike Superman, Angle Grinder Man couldn't leap over a parked Mini, and all sightings suggest that he is a human being, not a horse.
Union representation and training: The impact of Union Learning Representatives and the factors influencing their effectiveness

This article provides an assessment of the impact of Union Learning Representatives (ULRs) on both employer-funded and non-employer funded training in Britain. The findings, based upon the largest and most comprehensive national survey of ULRs conducted to date, suggest that while a significant proportion of ULRs have influenced training levels positively, a further 26 percent have had no positive impact on either employer-funded or non-employer funded training, and a further 13 percent have had a very limited impact. The article also develops an ‘Activity-Support-Characteristics’ (ASC) framework, and uses this framework to identify the factors that are associated with the ability of ULRs to influence training levels. The analysis shows ULRs are more likely to have had a positive impact on training where: they spend five hours a week or more on the role; they are supported by a workplace Learning Centre or a Union Learning Fund project; managers value their ULR activities; consultation or negotiation over training occurs; or the ULR represents no more than 200 employees.
How evolution can help us understand child development and behaviour

The traditional disease model, still dominant in psychiatry, is less than ideal for making sense of psychological issues such as the effects of early childhood experiences on development. We argue that a model based on evolutionary thinking can deepen understanding and aid clinical practice by showing how behaviours, bodily responses and psychological beliefs tend to develop for ‘adaptive’ reasons, even when these ways of being might on first appearance seem pathological. Such understanding has implications for treatment. It also challenges the genetic determinist model, by showing that developmental pathways have evolved to be responsive to the physical and social environment in which the individual matures. Thought can now be given to how biological or psychological treatments – and changing a child’s environment – can foster well-being. Evolutionary thinking has major implications for how we think about psychopathology and for targeting the optimum sites, levels and timings for interventions.
OLIVE : Speech Based Video

This paper describes the Olive project which aims to support automated indexing of video material by use of human language technologies. Olive is making use of speech recognition to automatically derive transcriptions of the sound tracks, generating time-coded linguistic elements which serve as the basis for text-based retrieval functionality. The retrieval demonstrator builds on and extends the architecture from the Pop-Eye project, a system applying human language technology on subtitles for the disclosure of video fragments.
An Affect Theory of Social Exchange1

This article develops a theory that explains how and when emotions, produced by social exchange, generate stronger or weaker ties to relations, groups, or networks. It is argued that social exchange produces positive or negative global feelings, which are internally rewarding or punishing. The theory indicates that social units (relations, groups, networks) are perceived as a source of these feelings, contingent on the degree of jointness in the exchange task. The jointness of the task is greatest if (1) actors find it difficult to distinguish their individual effects on or contributions to solving the exchange task (nonseparability) and (2) actors perceive a shared responsibility for success or failure at the exchange task. The theory explicates the effects of different exchange structures on these conditions and, in turn, on cohesion and solidarity. Implications are developed for network‐to‐group transformations.
Auditory ERP Differences in the Perception of Anticipated Speech Sequences in 5 - 6 Years Old Children and Adults

The perception of complex auditory information such as complete speech sequences develops during human ontogeny. In order to explore age differences in the auditory perception of predictable speech sequences we compared event-related potentials (ERPs) recorded in 5- to 6-year-old children (N = 15) and adults (N = 15) in response to anticipated speech sequences as successive and reverse digital series with randomly omitted digits. The ERPs obtained from the omitted digits significantly differed in the amplitude and latency of the N200 and P300 components between adults and children, the N400 and LPC components were more pronounced in children in the right frontal area for the digits presentation. These findings indicate that the perception of a successive speech structure is less automated in children and requires a detailed analysis of the successive structure and error detection. These differences in auditory ERPs reflect developmental changes in the auditory perception of speech sequences and can serve as indicators of the maturity of cognitive functions in children.
HTLV-1 Evades Type I Interferon Antiviral Signaling by Inducing the Suppressor of Cytokine Signaling 1 (SOCS1)

Human T cell leukemia virus type 1 (HTLV-1) is the etiologic agent of Adult T cell Leukemia (ATL) and the neurological disorder HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Although the majority of HTLV-1–infected individuals remain asymptomatic carriers (AC) during their lifetime, 2–5% will develop either ATL or HAM/TSP, but never both. To better understand the gene expression changes in HTLV-1-associated diseases, we examined the mRNA profiles of CD4+ T cells isolated from 7 ATL, 12 HAM/TSP, 11 AC and 8 non-infected controls. Using genomic approaches followed by bioinformatic analysis, we identified gene expression pattern characteristic of HTLV-1 infected individuals and particular disease states. Of particular interest, the suppressor of cytokine signaling 1—SOCS1—was upregulated in HAM/TSP and AC patients but not in ATL. Moreover, SOCS1 was positively correlated with the expression of HTLV-1 mRNA in HAM/TSP patient samples. In primary PBMCs transfected with a HTLV-1 proviral clone and in HTLV-1-transformed MT-2 cells, HTLV-1 replication correlated with induction of SOCS1 and inhibition of IFN-α/β and IFN-stimulated gene expression. Targeting SOCS1 with siRNA restored type I IFN production and reduced HTLV-1 replication in MT-2 cells. Conversely, exogenous expression of SOCS1 resulted in enhanced HTLV-1 mRNA synthesis. In addition to inhibiting signaling downstream of the IFN receptor, SOCS1 inhibited IFN-β production by targeting IRF3 for ubiquitination and proteasomal degradation. These observations identify a novel SOCS1 driven mechanism of evasion of the type I IFN antiviral response against HTLV-1.
Statin treatment after a recent TIA or stroke: is effectiveness shown in randomized clinical trials also observed in everyday clinical practice?

Lingsma HF, Steyerberg EW, Scholte op Reimer WJM, van Domburg R, Dippel DWJ, the Netherlands Stroke Survey Investigators. Statin treatment after a recent TIA or stroke: is effectiveness shown in randomized clinical trials also observed in everyday clinical practice? Acta Neurol Scand: 2010: 122: 15–20. © 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard.