Miracle-dz/UniFAR-FTUs huggingface dataset:
EduOntoWiki: The Evolution of an Ontology on Educational Sciences Towards a Socio-Relational Environment

The starting point for our project is the realization of an ontology of education sciences, about the concepts of "planning", "communication" and "evaluation". This was a result of the active involvement of both a community of practice of academics and one of actors (teachers and trainers) from different educational fields. It is this important social/relational aspect, which turned out to be increasingly significant in the course of this research, which led us to systematically further our knowledge and study of the relations of a community in the process of knowledge construction also as regards its permeability towards other social and educational contexts. 1 Ontologies and Communities Our research hypothesis is that only the transition from a technology-driven model to a community-driven model, where knowledge is constructed and formalised inside and outside communities of practice, can make ontological supports integrated within open learning systems, significant from a pedagogic point of view. The direction that the most promising, current research is taking indeed involves the study of the relations which unite the various communities and make them permeable in such a way that they can reciprocally share knowledge, contextualising it and enriching it with new meanings, and in the final analysis facilitating the solution of complex problems through the discovery of creative solutions. On the basis of these premises, we will seek to verify whether a social theory of learning can effectively lead to the overcoming of rigid borders between training/educational systems, work environments and social activities, and thus "free" learning so it is no longer seen to be linked to a specific area or moment of one's life, but actively constructed in the inter-community interactions of a lifelong learning continuum. What will be investigated in particular are the "negotiational" interrelations between people who, in various guises, are members of different communities, people who share an active interest for all training environments and who are bring valuable examples of "good practice" even if they belong to different contexts. The main aim of this research is to provide systematic procedures to try and codify the semantics of these processes, fostering the subsequent retrieval of knowledge which always accompanies these, and which constitutes a necessary added value. Fig. 1. An example of the EduOntoWiki environment describing the concept of assessment/evaluation (http://multifad.formazione.unipd.it:8080/eduonto).
Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses

p53 protects against cancer through its capacity to induce cell cycle arrest or apoptosis under a large variety of cellular stresses. It is not known how such diversity of signals can be integrated by a single molecule. However, the literature reveals that a common denominator in all p53‐inducing stresses is nucleolar disruption. We thus postulated that the impairment of nucleolar function might stabilize p53 by preventing its degradation. Using micropore irradiation, we demonstrate that large amounts of nuclear DNA damage fail to stabilize p53 unless the nucleolus is also disrupted. Forcing nucleolar disruption by anti‐upstream binding factor (UBF) microinjection (in the absence of DNA damage) also causes p53 stabilization. We propose that the nucleolus is a stress sensor responsible for maintenance of low levels of p53, which are automatically elevated as soon as nucleolar function is impaired in response to stress. Our model integrates all known p53‐inducing agents and also explains cell cycle‐related variations in p53 levels which correlate with established phases of nucleolar assembly/disassembly through the cell cycle.
Integration of Electric Vehicles in low voltage Danish distribution grids

Electric Vehicles (EVs) are considered as one of the important components of the future intelligent grids. Their role as energy storages in the electricity grid could provide local sustainable solutions to support more renewable energy. In order to estimate the extent of interaction of EVs in the electricity grid operation, a careful examination in the local electricity system is essential. This paper investigates the degree of EV penetration and its key influence on the low voltage distribution grids. Three detailed models of residential grids in Denmark are considered as test cases in this study, where alternate and flexible domestic solutions like EVs are inevitable for integrating the increasing amount of variable wind power. The result from these analyses shows that the individual feeder capabilities of handling an increasing amount of EV loads, is varied from 0-40% on an hourly basis. Also it is shown that there is enough head-space on the transformer capacity which can be used to charge many EVs during a day. The overall transformer capability of handling EV loads varies between 6-40% for peak and minimum demand hours, which is dependent on the robustness of the grids. The voltage drops are reflected as the major technical constraint to the stable operation of the electricity grids for integrating more EVs, when compared to the thermal loading on the cables.
Rapid Report

1 The aim of this study was to describe the time course of the response of human muscle protein synthesis (MPS) to a square wave increase in availability of amino acids (AAs) in plasma. We investigated the responses of quadriceps MPS to a ≈1.7‐fold increase in plasma AA concentrations using an intravenous infusion of 162 mg (kg body weight)−1 h−1 of mixed AAs. MPS was estimated from D3‐leucine labelling in protein after a primed, constant intravenous infusion of D3‐ketoisocaproate, increased appropriately during AA infusion. 2 Muscle was separated into myofibrillar, sarcoplasmic and mitochondrial fractions. MPS, both of mixed muscle and of fractions, was estimated during a basal period (2.5 h) and at 0.5‐4 h intervals for 6 h of AA infusion. 3 Rates of mixed MPS were not significantly different from basal (0.076 ± 0.008 % h−1) in the first 0.5 h of AA infusion but then rose rapidly to a peak after 2 h of ≈2.8 times the basal value. Thereafter, rates declined rapidly to the basal value. All muscle fractions showed a similar pattern. 4 The results suggest that MPS responds rapidly to increased availability of AAs but is then inhibited, despite continued AA availability. These results suggest that the fed state accretion of muscle protein may be limited by a metabolic mechanism whenever the requirement for substrate for protein synthesis is exceeded.
Establishing and functional characterization of an HEK-293 cell line expressing autofluorescently tagged β-actin (pEYFP-ACTIN) and the neurokinin type 1 receptor (NK1-R)

This study focused on establishing and making a comprehensive functional characterization of an HEK-293-transfected cell line that would coexpress the enhanced yellow fluorescent protein-actin (pEYFP-actin) construct and the neurokinin type 1 receptor (NK1-R), which is a member of the seven transmembrane (7TM) receptor family. In the initial selection procedure, the cloning ring technique was used alone, but failed to yield clones with homogenous pEYFP-actin expression. Flow cytometry sorting (FCS) was subsequently used to enrich the pEYFP-actin-expressing subpopulation of cells. The enzyme-linked immunosorbent assay (ELISA), FCS and quantitative real-time reverse transcription/polymerase chain reaction (RT-PCR) were then employed to monitor the passage-dependent effects on transgene expression and to estimate the total β-actin/pEYFP-actin ratio. NK1-R was characterized via radioactive ligand binding and the second messenger assay. The suitability of the pEYFP-actin as a marker of endogenous actin was assessed by colocalizing pEYFP-actin with rhodamine-phalloidine-stained F-actin and by comparing receptor- and jasplakinolide-induced changes in the actin cytoskeleton organization. These experiments demonstrated that: i) both constructs expressed in the generated transfected cell line are functional; ii) the estimated pEYFP-actin: endogenous β-actin ratio is within the limits required for the functional integrity of the actin filaments; and iii) pEYFP-actin and rhodamine-phalloidine-stained F-actin structures colocalize and display comparable reorganization patterns in pharmacologically challenged cells.
Characterizing user access to videos on the World Wide Web

Despite evidence of rising popularity of video on the web (or VOW), little is known about how users access video. However, such a characterization can greatly benefit the design of multimedia systems such as web video proxies and VOW servers. Hence, this paper presents an analysis of trace data obtained from an ongoing VOW experiment in Lulea University of Technology, Sweden. This experiment is unique as video material is distributed over a high bandwidth network allowing users to make access decisions without the network being a major factor. Our analysis revealed a number of interesting discoveries regarding user VOW access. For example, accesses display high temporal locality: several requests for the same video title often occur within a short time span. Accesses also exhibited spatial locality of reference whereby a small number of machines accounted for a large number of overall requests. Another finding was a browsing pattern where users preview the initial portion of a video to find out if they are interested. If they like it, they continue watching, otherwise they halt it. This pattern suggests that caching the first several minutes of video data should prove effective. Lastly, the analysis shows that, contrary to previous studies, ranking of video titles by popularity did not fit a Zipfian distribution.
Musical Training Enhances Neural Processing of Binaural Sounds

While hearing in noise is a complex task, even in high levels of noise humans demonstrate remarkable hearing ability. Binaural hearing, which involves the integration and analysis of incoming sounds from both ears, is an important mechanism that promotes hearing in complex listening environments. Analyzing inter-ear differences helps differentiate between sound sources–a key mechanism that facilitates hearing in noise. Even when both ears receive the same input, known as diotic hearing, speech intelligibility in noise is improved. Although musicians have better speech-in-noise perception compared with non-musicians, we do not know to what extent binaural processing contributes to this advantage. Musicians often demonstrate enhanced neural responses to sound, however, which may undergird their speech-in-noise perceptual enhancements. Here, we recorded auditory brainstem responses in young adult musicians and non-musicians to a speech stimulus for which there was no musician advantage when presented monaurally. When presented diotically, musicians demonstrated faster neural timing and greater intertrial response consistency relative to non-musicians. Furthermore, musicians' enhancements to the diotically presented stimulus correlated with speech-in-noise perception. These data provide evidence for musical training's impact on biological processes and suggest binaural processing as a possible contributor to more proficient hearing in noise.
Genetic bases of hypertriglyceridemic phenotypes

Purpose of review Hypertriglyceridemia (HTG) is a common diagnosis. Although secondary factors are important for clinical expression, susceptibility to HTG has a strong genetic component, which we review here. Recent findings Severe HTG in a few families follows Mendelian – typically autosomal recessive – inheritance of rare loss-of-function mutations in genes such as LPL, APOC2, APOA5, LMF1, and GPIHBP1. In contrast, common complex HTG results from the cumulative influence of small-effect variants (single nucleotide polymorphisms) in genes such as APOA5, GCKR, LPL, and APOB. Intensive resequencing of these four genes has also shown accumulated heterozygous rare variants in HTG patients. Together, more than 20% of the susceptibility to HTG is now accounted for by common and rare variants. Further, classical Fredrickson HTG phenotypes, which were once considered to be distinct based on biochemical features, have a shared genetic architecture. Summary Compared to other complex traits, genetic variants account for a high proportion of HTG diagnoses. By tallying the number of HTG risk alleles, it is possible to discriminate between individuals with HTG and normolipidemia, particularly in those with extreme scores. Future directions include finding the missing genetic component and determining whether genetic profiling can help with diagnosis or personalized treatment advice.
A virtual tripod for hand-held video stacking on smartphones

We propose an algorithm that can capture sharp, low-noise images in low-light conditions on a hand-held smartphone. We make use of the recent ability to acquire bursts of high resolution images on high-end models such as the iPhone5s. Frames are aligned, or stacked, using rolling shutter correction, based on motion estimated from the built-in gyro sensors and image feature tracking. After stacking, the images may be combined, using e.g. averaging to produce a sharp, low-noise photo. We have tested the algorithm on a variety of different scenes, using several different smartphones. We compare our method to denoising, direct stacking, as well as a global-shutter based stacking, with favourable results.
Propagation measurements of a 4G LTE network in Lagoon environment

Analysis of predicted and measured path loss over a Lagoon environment is presented. Propagation measurements were carried out at 1800 MHz, within a quarter of a year (May to August 2017) using Huawei Technologies drive test equipment. Measured data comprising of the received signal strength was taken for the initial measurements, measurements after first month, measurements after second month, and measurements after the third month. Measured path loss was compared with predictions made by free-space, log-distance, two-ray, COST 231-Hata, and Stanford University Interim (SUI) models. The COST-231 Hata model showed the most accurate performance with root mean square errors (RMSEs) of 10.03 dB, 12.38 dB, 17.59 dB, and 7.67 dB for the initial measurements, measurements after first month, measurements after second month, and measurements after third month, respectively. In order to achieve a more accurate prediction, the COST 231 Hata model was optimized using the least square algorithm. The optimized model showed improved signal prediction with RMSEs of 7.90 dB, 9.28 dB, 14.82 dB and 5.28 dB, respectively. The average RMSEs of the optimized COST 231 Hata model showed 9.32 dB compared with 11.92 dB predicted by the actual COST 231 Hata model. This accounts for about 21.81% improvements over the existing COST 231 Hata model. Therefore, the optimized COST 231-Hata model could be used to characterize radio channels in the investigated environments. Keywords: Propagation measurements, 4G LTE network, Lagoon environment, Pathloss models, Root mean squared error, Least square algorithm
A Model Assessing Innovativeness of Administration Units Awarding Public Contracts as a Tool to Conduct Economic Policy of the State

In today's market economy factors concerning knowledge, new technologies and innovative solutions are essential for economic development. However, the Polish economy, despite its high innovation potential compared to other European Union countries, is characterized by a very low level of innovativeness. Implementing this potential is conditioned with an appropriate economic policy of the state and rational approach to its resources and legal solutions. One of the possibilities of such an action is the use of public procurement instrument through which it is possible to more effectively create demand for innovative products and services. As shown by literature studies, the achievements of the subject literature associated with the creation of demand for innovations by public administration in Poland have been very modest. This gap is recognized the article and it attempts to build a model for assessing the innovativeness of these units. Network thinking methodology was used to build the model. As a result, after the identification of factors affecting the conduct of an innovative public procurement, a network of links was established between them and examined in terms of type, intensity and duration of exposure. Building a model according to the methodology, the opinions of experts have been used along with long-term observations conducted in the course of participation in all kinds of conferences and trainings. The model was also subjected to validation in two selected units.
Chirality and Semiconducting-Enriched Single-Walled Carbon Nanotubes and their Applications in Chemical Sensing and Memory Devices

Single-walled carbon nanotubes (SWCNTs) have shown true promise as highly sensitive chemical sensors and high-performance electronic devices. Only recently, methods have been developed to further purify and separate nanotubes by their electronic properties, metallic or semiconducting, and even by type as individual chiralities. These developments have opened up possibilities to further improve and understand the properties of SWCNTs on a fundamental level. In this work, the exquisite properties of chirality-enriched and semiconducting-enriched SWCNTs (s-SWCNTs) have been explored for applications as chemical sensors and memory storage devices. In the first project, column chromatography was used to separate and enrich specific SWNCT chiralities. Using the product from this process, it was found that the sensor response of chirality-enriched (7,5) SWCNT field-effect transistors (FETs) to monosubstituted benzenes show a linear relationship with the Hammett parameter of the species tested, as was previously found for SWCNT mixtures. In a second project, we explored the properties of poly(oxacyclobutane) (POCB) and its crystallization with water at room temperature to form a polymer hydrate crystal structure. This polycrystalline material was found to have aligned 1D columns of water contained within its structure and we found that the material can be capacitively charged. The crystallization of the polymer and water was observed with electronic measurement by s-SWCNT FET devices as a large increase in capacitance was observed upon crystallization. These POCB-coated s-SWCNT devices were applied as memory cell devices and showed bit separation of 10^4. In the final project, metal nanoparticle decorated s-SWCNT devices were applied as gas sensors in a proof of concept experiment using the AC heterodyne measurement technique. We showed that even in the presence of large charge transfer, such as hydrogen binding to palladium nanoparticles on the surface of SWCNTs, there is no signal with the AC method as opposed to the large signal observed in traditional DC FET measurement. Hydrogen sulfide elicited a sensor response in both AC and DC techniques as was expected.
Enhanced Bonding via Additive Manufacturing‐Enabled Surface Tailoring of 3D Printed Continuous‐Fiber Composites

Additive manufacturing (AM) of composites, particularly continuous fiber composites as studied here, is emerging as a new paradigm for creating advanced structures. Traditional machining and joining approaches will evolve or be fully displaced by AM approaches, and here the authors introduce a seminal investigation into AM‐enabled bonding/joining of continuous fiber composite laminates/multilayers. The AM‐enabled tailoring approach volumetrically increases surface area available for bonding by ∼150% by printing lines of continuous Nylon matrix filaments at an infill density of 50% to create a porous (∼50 vol%) bonding surface, rather than the conventional/baseline solid (100 vol%) surface approach. The AM‐tailored multilayers show improvements relative to the baseline single‐lap‐joint (SLJ) multilayer, and versus the industry‐standard surface preparation approach: 550% and 145% increases in ultimate strength, 10 000% and 800% increases in toughness, respectively, while maintaining joint stiffness. Benchmark mechanical performance data is established via the AM‐tailored bonding approach for carbon, glass, and Kevlar continuous fiber reinforced additively manufactured composite SLJ multilayers. AM‐enabled enhanced joining, such as the concept demonstrated here, is critical as AM components are increasingly being joined, both to each other and to other (non‐AM, different AM, etc.) structures in advanced applications.
Delay in Human Neutrophil Constitutive Apoptosis after Infection with Klebsiella pneumoniae Serotype K1

Klebsiella pneumoniae serotype K1 is a major cause of invasive syndrome defined by liver abscess with metastatic infections at other body sites. This culprit is known to be resistant to neutrophil phagocytosis and bactericidal activity. We hypothesized that K. pneumoniae serotype K1 might regulate neutrophil apoptosis and enhance the survival of the infected neutrophils that might serve as a vector for dissemination of the bacteria. Two serotypes of K. pneumoniae, KP-M1 isolated from a patient with liver abscess and DT-X (an acapsular mutant strain of KP-M1), were used to infect human neutrophils. The infected neutrophils were examined for their cytotoxicity, annexin V staining, proteins, DNA fragmentation, cytokine production, and viability that are involved in apoptosis. We found that KP-M1 was not destroyed and the ingested bacteria survived within neutrophils. While the uninfected neutrophils became apoptotic within 10 h, the neutrophils infected with KP-M1 could survive up to 24 h post infection. Constitutive apoptosis of KP-M1-infected neutrophils was significantly delayed compared to that of DT-X-infected or uninfected neutrophils (p < 0.01). KP-M1 modulated the anti-apoptotic effects by down-regulating the ratio of Bax to Bcl-2 and Mcl-1, and then delayed caspase-3 activation in the neutrophils, which was accompanied by inducing the anti-apoptotic cytokine, IL-8. These data suggest that K. pneumoniae serotype K1 can prolong the lifespan of infected neutrophils by delaying constitutive apoptosis within the first several hours of infection.
Theory of the density fluctuation spectrum of strongly correlated electrons.

The density response function {ital N}({bold q},{omega}) of the two-dimensional {ital t}-{ital J} model is studied starting from a mixed- gauge formulation of the slave-boson approach. Our results for {ital N}({bold q},{omega}) are in remarkable agreement with exact diagonalization studies, and provide a natural explanation of the anomalous features in the density response in terms of the spin-polaron nature of the charge carriers. In particular, we have identified unexplained low-energy structures in the diagonalization data as arising from the coherent polaron motion of holes in a spin liquid. {copyright} {ital 1996 The American Physical Society. }