Miracle-dz/UniFAR-FTUs huggingface dataset:
Mobile Visual Search

Current mobile search is mainly based on keyword or text, with limited capability in describing real-world objects. In many cases, a query in image taken by the smart phone is simply more descriptive. Mobile devices have shown great potential for visual search, Emerging applications include landmark search, dress product search, book search, location recognition, and scene retrieval, etc. The challenge for mobile visual search is how to cost down the task with high speed searching. In addition, a practical issue remains open on how to make visual search applications compatible across a broad range of devices and platforms. In this talk, I will discuss the key research efforts on CDVS by many teams from academia, and reviewing the standardization activity took by ISO/IEC MPEG working group. A competitive and collaborative platform to evaluate the state-of- the-art visual search techniques and solutions will be given as well, where learning techniques have been shown to be the most promising approach to improve the performance and efficiency of mobile visual search.
The Integration of Two Domain Conceptualizations in a Single Adaptive Hypermedia System

One of the main purposes of using ontologies for knowledge modeling in adaptive systems is knowledge reuse and interoperability. Commitment of knowledge models to a common ontology can potentially help to solve a number of traditional problems found in adaptive systems, including cross-application personalization. A new version of the adaptive educational hypermedia system QuizGuide integrates two domain models, based on different conceptualizations of C programming, and models student knowledge according to both of them. In this paper, we analyze the benefits of the integration due to the interaction of these models and discuss the forthcoming evolution of the system, based on communication with the ontology server.
Ancient Human Parasites in Ethnic Chinese Populations

Whilst archaeological evidence for many aspects of life in ancient China is well studied, there has been much less interest in ancient infectious diseases, such as intestinal parasites in past Chinese populations. Here, we bring together evidence from mummies, ancient latrines, and pelvic soil from burials, dating from the Neolithic Period to the Qing Dynasty, in order to better understand the health of the past inhabitants of China and the diseases endemic in the region. Seven species of intestinal parasite have been identified, namely roundworm, whipworm, Chinese liver fluke, oriental schistosome, pinworm, Taenia sp. tapeworm, and the intestinal fluke Fasciolopsis buski. It was found that in the past, roundworm, whipworm, and Chinese liver fluke appear to have been much more common than the other species. While roundworm and whipworm remained common into the late 20th century, Chinese liver fluke seems to have undergone a marked decline in its prevalence over time. The iconic transport route known as the Silk Road has been shown to have acted as a vector for the transmission of ancient diseases, highlighted by the discovery of Chinese liver fluke in a 2,000 year-old relay station in northwest China, 1,500 km outside its endemic range.
Stereoscopic visual fatigue measurement based on fusional response curve and eye-blinks

In this paper, we propose an experiment that assesses fusional response curve and eye-blink rate to measure visual fatigue induced by stereoscopic videos. A random dot stereogram was utilized to measure the reliable fusional limit and response curve acquired by determining the direction of Landolt C. The results were analyzed to discriminate the individual ability of 3D fusion and compared with the results of subjective evaluation and descriptive self-report. It shows that while watching 3D video, viewers who have slow fusional response and low fusional limits are more sensitive to visual fatigue. In addition, eye-blinks were measured using eye images captured by a camera. Eye-blinks were increased in the video with moderate visual fatigue than low visual fatigue and decreased more in the second half than the first half of the session.
Hematogenous Metastasis in Gastric Cancer Requires Isolated Tumor Cells and Expression of Vascular Endothelial Growth Factor Receptor-1

Purpose: Recent studies of cancer metastasis have focused on the role of premetastatic gene expression and circulating tumor cells. We did a blind prospective study in gastric cancer to assess the significance of isolated tumor cells (ITC) and to test the hypothesis that vascular endothelial growth factor receptor-1 (VEGFR-1) is expressed within the bone marrow at tumor-specific, premetastatic sites. Experimental Design: Both bone marrow and peripheral blood samples from 810 gastric cancer patients were collected at the Central Hospital, National Cancer Center (Tokyo, Japan). The samples were transferred to Kyushu University Hospital (Beppu, Japan) where they were analyzed by quantitative real-time reverse transcription-PCR for three epithelial cell markers, carcinoembryonic antigen, cytokeratin-19, and cytokeratin-7, as well as VEGFR-1. Results: ITCs were observed in peripheral blood and bone marrow even in early stages of gastric cancer. The frequency of ITC in bone marrow was significantly associated with the stage of disease by ANOVA (P < 0.01). Gastric cancer metastasized when ITCs were observed in the presence of VEGFR-1. In the 380 patients who were ITC negative and showed low VEGFR-1 expression, synchronous (at the time of surgery) and heterochronous (recurrent) metastases were not observed. Conclusions: ITCs circulate even in early stages of disease. Furthermore, elevated expression of VEGFR-1 facilitates the establishment of hematogenous metastases in gastric cancer. This study indicates that the simultaneous presence of ITC and VEGFR-1 expression at premetastatic sites is clinically significant for disease progression.
CLINICAL CONCEPTS AND COMMENTARY

AS part of the effort to develop mechanisms-based approaches to pain therapy, renewed interest has focused on the use of ketamine for treatment of acute and chronic pain. In particular, the role of N-methyl-D-aspartate (NMDA) excitatory glutamate receptors in nociceptive transmission has been established in humans. NMDA receptors participate in the development and maintenance of what can be called “pathologic pain” after tissue injury: increased pain perception as a result of pain sensitization, in part from synaptic plasticity. Ketamine binds noncompetitively to the phencyclidine binding site of NMDA receptors but also modifies them via allosteric mechanisms. When studied at subanesthetic doses, its analgesic efficacy correlates well with its inhibiting action on NMDA receptor-mediated pain facilitation and a decrease in activity of brain structures that respond to noxious stimuli. Ketamine therefore represents a promising modality in several perioperative strategies to prevent pathologic pain. Another reason for the renewed interest in ketamine is the availability of S( ) ketamine. Ketamine has a chiral center at the carbon-2 atom of the cyclohexanone ring, and therefore exists as the optical stereoisomers S( ) and R(-) ketamine. Until recently, ketamine was marketed as a racemate, containing equimolar amounts of the enantiomers. S( ) ketamine has a fourfold greater affinity for NMDA receptors than does R(-) ketamine. This difference results in a clinical analgesic potency of S( ) ketamine approximately two times greater than that of racemic and four times greater than that of R(-) ketamine, whereas S( ) ketamine has a shorter duration of action. We discuss the perioperative use of ketamine as an adjunct to general and regional anesthesia and to postoperative pain therapy. Focus will be on the administration of the drug at subanesthetic concentrations; we will refer to this as “subanesthetic ketamine. ” Anti-nociceptive Therapy with Ketamine during Anesthesia
Optimization of a simulated iron-oxide pellets induration furnace

Induration furnaces for iron-oxide pellets are expensive processes, due to their high energy consumption. Moreover, they are highly interactive and then complex to control. Real-time optimization strategies based on reliable process models are thus necessary. However, induration furnaces are described by distributed-parameter models that require long computation times. The performance of IMCoptimization [1], an easy to implement static nonlinear optimization algorithm, is compared to a direct optimization based on the nonlinear process model itself. For a simulated induration furnace, it is shown that the accuracy obtained with the IMC-optimization algorithm is quite sufficient and does not require considerable computation efforts.
Using genetic algorithms to mine process models : representation, operators and results

The topic of process mining has attracted the attention of both researchers and tool vendors in the Business Process Management (BPM) space. The goal of process mining is to discover process models from event logs, i.e., events logged by some information system are used to extract information about activities and their causal relations. Several algorithms have been proposed for process mining. Many of these algorithms cannot deal with concurrency. Other typical problems are the presence of duplicate activities, hidden activities, non-free-choice constructs, etc. In addition, real-life logs contain noise (e.g., exceptions or incorrectly logged events) and are typically incomplete (i.e., the event logs contain only a fragment of all possible behaviors). To tackle these problems we propose a completely new approach based on genetic algorithms. In this paper, we present a new process representation, a fitness measure and the genetic operators used in a genetic algorithm to mine process models. Our focus is on the use of the genetic algorithm for mining noisy event logs. Additionally, in the appendix we elaborate on the relation between Petri nets and this representation and show that genetic algorithms can be used to discover Petri net models from event logs.
STROBE—Radiation Ulcer: An Overlooked Complication of Fluoroscopic Intervention

AbstractWith increasing numbers of percutaneous coronary intervention (PCI) and complex cardiac procedures, higher accumulated radiation dose in patient has been observed. We speculate cardiac catheter intervention induced radiation skin damage is no longer rare.To study the incidence of cardiac fluoroscopic intervention induced radiation ulcer.We retrospectively reviewed medical records of those who received cardiac fluoroscopic intervention in our hospital during 2012 to 2013 for any events of radiation ulcer. Only patients, whose clinical photos were available for reviewing, would be included for further evaluation. The diagnosis of radiation ulcers were made when there is a history of PCI with pictures proven skin ulcers, which presented typical characteristics of radiation injury.Nine patients with radiation ulcer were identified and the incidence was 0.34% (9/2570) per practice and 0.42% (9/2124) per patient. Prolonged procedure time, cumulative multiple procedures, right coronary artery occlusion with chronic total occlusion, obesity, and diabetes are frequent characteristics. The onset interval between the first skin manifestation and the latest radiation exposure varied from 3 weeks to 3 months. The histopathology studies failed to make diagnosis correctly in 5 out of 6 patients. To make thing worse, skin biopsy exacerbated the preexisting radiation dermatitis. Notably, all radiation ulcers were refractory to conventional wound care. Surgical intervention was necessary to heal the wound.Diagnosis of cardiac fluoroscopy intervention induced radiation skin damage is challenging and needs high index of clinical suspicion. Minimizing the radiation exposure by using new approaches is the most important way to prevent this complication. Patient education and a routine postprocedure dermatology follow up are mandatory in high-risk groups for both radiation skin damage and malignancies.This is a retrospective study, thus the true incidence of radiation ulcer caused by cardiac fluoroscopic intervention could be higher.
Interconnect width selection for deep submicron designs using the table lookup method

Interconnect width sizing is critical in deep submicron designs to reduce the overall delay. In this paper we present an algorithm for optimal interconnect width selection from a predetermined and precharacterized wire width metric. This algorithm uses a 4-dimensional lookup table approach based on "O'Brien, Savarino" π model for the interconnect load. This methodology can easily be integrated into the existing design tools since this methodology lies in the middle of the postplacement and prerouting step of the physical design flow. We will explore a trade-off between delay and power dissipation for different widths and a comparison will also be made with the ITRS design rules.
Split-Perfect Graphs: Characterizations and Algorithmic Use

Two graphs G and H with the same vertex set V are P4- isomorphic if every four vertices {a, b, c, d} ⊆ V induce a chordless path (denoted by P4) in G if and only if they induce a P4 in H. We call a graph split-perfect if it is P4-isomorphic to a split graph (i.e. a graph being partitionable into a clique and a stable set). This paper characterizes the new class of split-perfect graphs using the concepts of homogeneous sets and p-connected graphs, and leads to a linear time recognition algorithm for split-perfect graphs, as well as linear time algorithms for classical optimization problems on split-perfect graphs based on the primeval decomposition of graphs. These results considerably extend previous ones on smaller classes such as P4-sparse graphs, P4-lite graphs, P4-laden graphs, and (7,3)-graphs. Moreover, split-perfect graphs form a new subclass of brittle graphs containing the superbrittle graphs for which a new characterization is obtained leading to linear time recognition.
Family-Based Treatment of Severe Pediatric Obesity: Randomized, Controlled Trial

OBJECTIVE: We evaluated the efficacy of family-based, behavioral weight control in the management of severe pediatric obesity. METHODS: Participants were 192 children 8.0 to 12.0 years of age (mean ± SD: 10.2 ± 1.2 years). The average BMI percentile for age and gender was 99.18 (SD: 0.72). Families were assigned randomly to the intervention or usual care. Assessments were conducted at baseline, 6 months, 12 months, and 18 months. The primary outcome was percent overweight (percent over the median BMI for age and gender). Changes in blood pressure, body composition, waist circumference, and health-related quality of life also were evaluated. Finally, we examined factors associated with changes in child percent overweight, particularly session attendance. RESULTS: Intervention was associated with significant decreases in child percent overweight, relative to usual care, at 6 months. Intent-to-treat analyses documented that intervention was associated with a 7.58% decrease in child percent overweight at 6 months, compared with a 0.66% decrease with usual care, but differences were not significant at 12 or 18 months. Small significant improvements in medical outcomes were observed at 6 and 12 months. Children who attended ≥75% of intervention sessions maintained decreases in percent overweight through 18 months. Lower baseline percent overweight, better attendance, higher income, and greater parent BMI reduction were associated with significantly greater reductions in child percent overweight at 6 months among intervention participants. CONCLUSIONS: Intervention was associated with significant short-term reductions in obesity and improvements in medical parameters and conferred longer-term weight change benefits for children who attended ≥75% of sessions.
1 VEGF INDUCES MCL-1 UPREGULATION AND PROTECTS MULTIPLE MYELOMA CELLS AGAINST APOPTOSIS

(4217 articles) Neoplasia  (1086 articles) Gene Expression  (746 articles) Apoptosis  Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary. org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://bloodjournal.hematologylibrary. org/site/misc/rights.xhtml#reprints Information about ordering reprints may be found online at: http://bloodjournal.hematologylibrary. org/site/subscriptions/index.xhtml Information about subscriptions and ASH membership may be found online at:
Network protection against worms and cascading failures using modularity partitioning

Communication networks are prone to virus and worms spreading and cascading failures. Recently, a number of social networking worms have spread over public Web sites. Another example is error propagation in routing tables, such as in BGP tables. The immunization and error curing applied to these scenarios are not fast enough. There have been studies on the effect of isolating and curing network elements, however, the proposed strategies are limited to node removals. This paper proposes a link isolation strategy based on the quarantining of susceptible clusters in the network. This strategy aims to maximize the epidemic control while minimizing the impact on the clusters performance. We empirically study the influence of clustering on robustness against epidemics in several real-world and artificial networks. Our results show an average curing rate improvement above 50% for the studied real-world networks under analysis.
The impact of the students' age on the literary text analysis approach: Teaching methods and approaches in primary education

Literary text analysis is part of the Language Arts and 4e Language and Literature Curriculum in the primary education. Teachers are expected to practice di:erent types of teaching methods depending on the age of the students, such as: demonstration, whole class work, reading and working on a text, discussion, conversation, students’ oral presentations and creative writing. Students can also do literary analysis in groups, pairs, individually and in whole-class work. 4e aim of this paper is to answer the question whether teachers employ di:erent teaching methods and approaches in the process of students’ responses to literary texts and the literary text analysis depending on their age and if they prefer some of the methods over others relative to students’ age. We have collected the necessary data for this descriptive research by conducting surveys that were speciFcally designed for the purpose of the research with the random sample of primary school teachers in the Republic of Macedonia (total N=75). Descriptive analysis and ANOVA – single factor were used as well. 4e results have shown that the teachers practice di:erent teaching approaches depending on the students’ age in the process of literary text analysis in class, which is graphically presented and discussed in the paper. 4e results did not show any signiFcant di:erences among the general teaching methods used in di:erent classes in primary education. 4e methods and approaches that teachers use are compared to the ones that are considered to be part of the modern trends according to the latest research. 4e results of the research will help scholars to build a broader picture of the literary analysis lessons in the primary school in the Republic of Macedonia regarding the teaching methods and approaches that are employed for the purpose of obtaining the age-appropriate classroom atmosphere. It will also contribute to the process of teacher reTections about the methods and approaches that they are using in order to improve the quality of teaching while bearing in mind the contemporary trends of building interactive classrooms in which the students are responsible for their own learning.
Significance of Circulating Tumor Cells Detected by the CellSearch System in Patients with Metastatic Breast Colorectal and Prostate Cancer

The increasing number of treatment options for patients with metastatic carcinomas has created a concomitant need for new methods to monitor their use. Ideally, these modalities would be noninvasive, be independent of treatment, and provide quantitative real-time analysis of tumor activity in a variety of carcinomas. Assessment of circulating tumor cells (CTCs) shed into the blood during metastasis may satisfy this need. We developed the CellSearch System to enumerate CTC from 7.5 mL of venous blood. In this review we compare the outcomes from three prospective multicenter studies investigating the use of CTC to monitor patients undergoing treatment for metastatic breast (MBC), colorectal (MCRC), or prostate cancer (MPC) and review the CTC definition used in these studies. Evaluation of CTC at anytime during the course of disease allows assessment of patient prognosis and is predictive of overall survival.
Computer vision-based gesture recognition for an augmented reality interface

Wearable computing and Augmented Reality applications call for less obtrusive and more intuitive human computer interfaces than keyboards and mice. One way to realise such interfaces is using gestures, e.g., for pointing in order to replace the mouse. The less obtrusive way of gesture recognition is to use computer vision based methods. This paper presents a computer vision-based gesture interface that is part of an Augmented Reality system. It can recognise a 3D pointing gesture, a click gesture, and five static gestures. A lookup-table based colour segmentation and a fast gesture recognition method are presented that enable for 25Hz performance on a standard PC.
Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse

Virulence in the ubiquitous intracellular protozoon Toxoplasma gondii for its natural intermediate host, the mouse, appears paradoxical from an evolutionary standpoint because death of the mouse before encystment interrupts the parasite life cycle. Virulent T. gondii strains secrete kinases and pseudokinases that inactivate the immunity-related GTPases (IRG proteins) responsible for mouse resistance to avirulent strains. Such considerations stimulated a search for IRG alleles unknown in laboratory mice that might confer resistance to virulent strains of T. gondii. We report that the mouse IRG system shows extraordinary polymorphic complexity in the wild. We describe an IRG haplotype from a wild-derived mouse strain that confers resistance against virulent parasites by interference with the virulent kinase complex. In such hosts virulent strains can encyst, hinting at an explanation for the evolution of virulence polymorphism in T. gondii. DOI: http://dx.doi. org/10.7554/eLife.01298. 001
Vision based station keeping and docking for floating vehicles

This paper describes a method for station keeping and docking of floating vehicles. We consider the case of a lighter-than-air blimp and that of an underwater robot. Due to the motion disturbances in the environment (currents), these tasks are important to keep the vehicle stabilized relative to an external reference frame. The main difficulties to achieve station keeping and docking are related to the non-holonomic constraints of the floating vehicles moving in 3D, having a limited number of controllable degrees of freedom. The relative position of the vehicle with respect to a docking station is tracked using vision. A planar surface is chosen as a reference plane which allows visual tracking of an environmental region, based on planar projective transformations. An image-based control law is proposed together with a dynamic model for the vehicles. Experiments both with a blimp and an underwater vehicle are described and discussed.