Miracle-dz/UniFAR-FTUs huggingface dataset:
Circulating gonadotrophins during a period of restricted energy intake in relation to body condition in heifers.

Beef heifers, 13 months old, were fed to achieve high (7.6 +/- 0.2 units) or low (3.9 +/- 0.1 units) body condition by feeding them one of two diets for 20 weeks. During week 17 of the growth phase, all heifers were ovariectomized. From week 20 to week 27 (restriction phase), all heifers were fed a daily diet containing 0.071 MJ metabolizable energy kg-1 body weight. At weekly intervals throughout the restriction phase, blood samples were collected at 10-min intervals for 11 h to determine the pattern of secretion of luteinizing hormone (LH), the amount of LH released in response to 750 ng (pituitary responsiveness) and 50 micrograms LH-releasing hormone (LHRH, releasable stores) and mean concentrations of follicle-stimulating hormone (FSH) in the circulation. Body weight declined during the restriction phase in a similar fashion in heifers with high and low body condition and changes in body weight were unrelated to mean concentrations of LH and FSH and frequency of LH pulses. Amplitude of LH pulses and responsiveness to 750 ng LHRH increased in a linear fashion with weight loss in heifers with low but not in those with high body condition. The amount of LH released in response to 50 micrograms LHRH decreased with increasing weight loss in heifers with high but not with low body condition, indicating that releasable pools of LH declined with increased weight loss in heifers with high body condition. (ABSTRACT TRUNCATED AT 250 WORDS)
Increased levels of cytosolic phospholipase A2 in dyslexics.

Research findings are increasingly reporting evidence of physiological abnormalities in dyslexia and sites for dyslexia have been identified on three chromosomes. It has been suggested that genetic inheritance may cause phospholipid abnormalities in dyslexia somewhat similar to those found in schizophrenia. A key enzyme in phospholipid metabolism, Type IV, or cytosolic, phospholipase A2 (cPLA2), releases arachidonic acid (AA), a 20-carbon fatty acid, which is the major source of production of prostaglandins and leukotrienes. An entirely new assay, which for the first time has enabled determination of the amount of the enzyme rather than its activity, was used to measure cPLA2 in dyslexic-type adults and controls and the two groups were found to differ significantly, the dyslexic-types having more of the enzyme. A report elsewhere of schizophrenics having even greater amounts of the enzyme suggests that dyslexia may be on a continuum with schizophrenia, as may be other neurodevelopmental disorders - which have also been described as phospholipid spectrum disorders.
A Yield Spread Perspective on the Great Financial Crisis: Break-Point Test Evidence

We use a simple partial adjustment econometric framework to investigate the effects of the crisis on the dynamic properties of a number of yield spreads. We find that the crisis has caused substantial disruptions revealed by changes in the persistence of the shocks to spreads as much as by in their unconditional mean levels. Formal breakpoint tests confirm that the financial crisis has been over approximately since the Spring of 2009. The financial crisis can be conservatively dated as a August 2007 – June 2009 phenomenon, although some yield spread series seem to point out to an end of the most serious disruptions as early as in December 2008. We uncover evidence that the LSAP program implemented by the Fed in the US residential mortgage market has been effective, in the sense that the risk premia in this market have been uniquely shielded from the disruptive effects of the crisis.
Antisocial behavior in organizations.

The Role of Frustration in Antisocial Behavior at Work - Paul E Spector At the Breaking Point - Robert J Bies, Thomas M Tripp and Roderick M Kramer Cognitive and Social Dynamics of Revenge in Organizations Aggression in the Workplace - Joel H Neuman and Robert A Baron Lying in Organizations - Steven L Grover Theory, Research and Future Directions The STEAL Motive - Jerald Greenberg Managing the Social Determinants of Employee Theft Employee Sabotage - Robert A Giacalone, Catherine A Riordan and Paul Rosenfeld Toward a Practitioner-Scholar Understanding Whistle-Blowing as Antisocial Behavior - Marcia P Miceli and Janet P Near Litigation and Claiming in Organizations - E Allan Lind Antisocial Behavior or Quest for Justice? Organizational Culture and Employee Counterproductivity - Michael W Boye and John W Jones
Weak coupling of solutions of first-order least-squares method

A theoretical analysis of a first-order least-squares finite element method for second-order self-adjoint elliptic problems is presented. We investigate the coupling effect of the approximate solutions u h for the primary function u and σ h for the flux σ = -A∇u. We prove that the accuracy of the approximate solution u h for the primary function u is weakly affected by the flux σ = -A∇u. That is, the bound for ||u - u h ||1 is dependent on σ, but only through the best approximation for σ multiplied by a factor of meshsize h. Similarly, we provide that the bound for ||σ - σ h || H(div) is dependent on u, but only through the best approximation for u multiplied by a factor of the meshsize h. This weak coupling is not true for the non-selfadjoint case. We provide the numerical experiment supporting the theorems in this paper.
Dosimetric Simulations of Brain Absorption of Mobile Phone Radiation–The Relationship Between psSAR and Age

As children develop, they differ from adults in a number of important ways, including anatomy, metabolism, immune system, and the extent of myelination of the nervous system. As a consequence, equivalent exposures to radiation from mobile phones result in different doses to specific tissues in children compared with adults. Higher doses are likely to have more severe implications in the young. A young child's skull is not only smaller and thinner than an adult's, but also has dielectric characteristics closer to those of soft tissues, probably due to a higher water content. The young skull better matches the electromagnetic characteristics of the skin and brain. As a result, finite-difference time-domain (FDTD) simulations confirm field penetration and higher specific absorption rate (SAR) in deeper structures in the young brain. If the peak spatial SAR (psSAR) is modeled in the entire head, as current testing standards recommend, the results for adults and children are equivalent. Our anatomically based evaluations rely on FDTD simulations of different tissues within the brain and confirm that the psSAR in a child's brain is higher than in an adult's brain.
Recent Advances in the Cellular and Molecular Mechanisms of Hypothalamic Neuronal Glucose Detection

The hypothalamus have been recognized for decades as one of the major brain centers for the control of energy homeostasis. This area contains specialized neurons able to detect changes in nutrients level. Among them, glucose-sensing neurons use glucose as a signaling molecule in addition to its fueling role. In this review we will describe the different sub-populations of glucose-sensing neurons present in the hypothalamus and highlight their nature in terms of neurotransmitter/neuropeptide expression. This review will particularly discuss whether pro-opiomelanocortin (POMC) neurons from the arcuate nucleus are directly glucose-sensing. In addition, recent observations in glucose-sensing suggest a subtle system with different mechanisms involved in the detection of changes in glucose level and their involvement in specific physiological functions. Several data point out the critical role of reactive oxygen species (ROS) and mitochondria dynamics in the detection of increased glucose. This review will also highlight that ATP-dependent potassium (KATP) channels are not the only channels mediating glucose-sensing and discuss the new role of transient receptor potential canonical channels (TRPC). We will discuss the recent advances in the determination of glucose-sensing machinery and propose potential line of research needed to further understand the regulation of brain glucose detection.
Detecting patterns of change using enhanced parallel coordinates visualization

Analyzing data to find trends, correlations, and stable patterns is an important problem for many industrial applications. We propose a new technique based on parallel coordinates visualization. Previous work on parallel coordinates method has shown that they are effective only when variables that are correlated and/or show similar patterns are displayed adjacently. Although current parallel coordinates tools allow the user to manually rearrange the order of variables, this process is very time-consuming when the number of variables is large. Automated assistance is needed. We propose an edit-distance based technique to rearrange variables so that interesting patterns can be easily detected. Our system, V-Miner, includes both automated methods for visualizing common patterns and a query tool that enables the user to describe specific target patterns to be mined/displayed by the system. Following an overview of the system, a case study is presented to explain how Motorola engineers have used V-Miner to identify significant patterns in their product test and design data.
Potential hazards and artifacts of ferromagnetic and nonferromagnetic surgical and dental materials and devices in nuclear magnetic resonance imaging.

The risks to patients with metal surgical implants who are undergoing nuclear magnetic resonance (NMR) imaging and the artifacts caused by such implants were studied. Twenty-one aneurysm and other hemostatic clips and a variety of other materials (e.g., dental amalgam, 14 karat gold) were used. Longitudinal forces and torques were found to be exerted upon 16 of the 21 clips. With five aneurysm clips, forces and torques sufficient to produce risk of hemorrhage from dislocation of the clip from the vessel or aneurysm, or cerebral injury by clip displacement without dislodgement were identified. The induced ferromagnetism was shown to be related to the composition of the alloys from which the clips were manufactured. Clips with 10-14% nickel are evidently without sufficient induced ferromagnetism to cause hazard. The extent of NMR imaging artifacts was greater for materials with measurable ferromagnetic properties, but metals without measurable ferromagnetism in our tests also resulted in significant artifacts. Dental amalgam and 14 karat gold produced no imaging artifacts, but stainless steels in dentures and orthodontic braces produced extensive artifacts in the facial region.
A derivation of Witten's conjecture relating Donaldson and Seiberg-Witten invariants

We generalize Witten’s conjectured formula relating Donaldson and Seiberg– Witten invariants to manifolds of non-simple type, via equivariant localization techniques. This approach does not use the theory of non-abelian monopoles, but works directly on the Donaldson–Witten and Seiberg–Witten moduli spaces. We give a formal derivation of Witten’s conjecture and its generalization, making use of an inﬁnite dimensional version of the abelian localization theorem.
Subtyping of European foot-and-mouth disease virus strains by nucleotide sequence determination

The VP1-coding regions of foot-and-mouth disease virus strains from 18 recent European outbreaks and of 9 strains isolated more than 20 years ago and used in part as vaccines were determined by direct cDNA sequencing. Comparison of the sequences revealed that most of the isolated outbreak viruses are closely related to the vaccine strains used. Isolates from the Italian epizootic of 1984 to 1985 correspond, for example, to the vaccine strain A5 Parma 62; the outbreak in 1984 in Bernbeuren, Federal Republic of Germany, was induced by A5 Allier 60; outbreaks in 1982 in Funen, Denmark, and in Murchin, German Democratic Republic, were caused by O1 Lausanne 65. Viruses isolated during the 1983 Iberian epizootic show a close relationship to the vaccine strain A5 Allier 60 but were probably derived from another not yet identified vaccine strain from Spain. Only two minor outbreaks in the Federal Republic of Germany, A Aachen in 1976 and O Wuppertal in 1982, did not correspond to the classical European strains but were obviously introduced from outside. We suggest that nucleotide sequence analysis should be used as a standard method of diagnosis, because when compared with other techniques it more clearly reveals the origin and course of epizootics and offers the possibility of preventing further outbreaks.
Adenosine Triphosphate and the Late Steps in Calcium-dependent Exocytosis at a Ribbon Synapse

The ATP dependence of the kinetics of Ca2+-dependent exocytosis after flash photolysis of caged Ca2+ was studied by capacitance measurements with submillisecond resolution in single synaptic terminals of retinal bipolar neurons. After control experiments verified that this combination of techniques is valid for the study of exocytosis in synaptic terminals, a comparison was made between the Ca2+ dependence of the rate of exocytosis in synaptic terminals internally dialyzed with MgATP, MgATP-gamma-S, or no added Mg2+ or nucleotide. The Ca2+ threshold for release, the maximum rate of release, and the overall relationship between the rate of synaptic vesicle fusion and [Ca2+]i were found to be independent of MgATP. A decrease in the average rate at near-threshold [Ca2+]i was observed in terminals with MgATP-gamma-S, but due to the small sample size is of unclear significance. The Ca2+ dependence of the delay between the elevation of [Ca2+]i and the beginning of the capacitance rise was also found to be independent of MgATP. In contrast, MgATP had a marked effect on the ability of terminals to respond to multiple stimuli. Terminals with MgATP typically exhibited a capacitance increase to a second stimulus that was >70% of the amplitude of the first response and to a third stimulus with a response amplitude that was >50% of the first, whereas terminals without MgATP responded to a second stimulus with a response <35% of the first and rarely responded to a third flash. These results suggest a major role for MgATP in preparing synaptic vesicles for fusion, but indicate that cytosolic MgATP may have little role in events downstream of calcium entry, provided that [Ca2+]i near release sites is elevated above approximately 30 microM.
Study of transmission line performance on through silicon interposer

The high frequency performance of different types of transmission line structures (including microstrip line, coplanar waveguide, grounded coplanar waveguide and differential coplanar waveguide) fabricated on through silicon interposer (TSI) is studied and characterized experimentally up to 40 GHz in this paper. Design considerations and tradeoffs are discussed in order to realize low loss, high bandwidth interconnects on TSI for radio frequency and/or millimeter wave system integration. Experimental results reveal that all the designed transmission line structures have insertion loss of less than 0.56 dB/mm for frequencies up to 40 GHz. Good impedance matching over broad frequency range (till 40 GHz) is also achieved with return loss of greater than 15 dB. Additionally, for the differential coplanar waveguide structure, high isolation of more than 27 dB for frequencies up to 40 GHz is observed between the differential and common mode conversion.
Widespread Genomic Signatures of Natural Selection in Hominid Evolution

Selection acting on genomic functional elements can be detected by its indirect effects on population diversity at linked neutral sites. To illuminate the selective forces that shaped hominid evolution, we analyzed the genomic distributions of human polymorphisms and sequence differences among five primate species relative to the locations of conserved sequence features. Neutral sequence diversity in human and ancestral hominid populations is substantially reduced near such features, resulting in a surprisingly large genome average diversity reduction due to selection of 19-26% on the autosomes and 12-40% on the X chromosome. The overall trends are broadly consistent with "background selection" or hitchhiking in ancestral populations acting to remove deleterious variants. Average selection is much stronger on exonic (both protein-coding and untranslated) conserved features than non-exonic features. Long term selection, rather than complex speciation scenarios, explains the large intragenomic variation in human/chimpanzee divergence. Our analyses reveal a dominant role for selection in shaping genomic diversity and divergence patterns, clarify hominid evolution, and provide a baseline for investigating specific selective events.
Cross-resistance associated with development of resistance to isometamidium in a clone of Trypanosoma congolense

Resistance to isometamidium was increased 94-fold in a clone of Trypanosoma congolense (clone IL 1180) by repeated subcurative treatment of infected mice for 11 months. This was associated with 3.4-, 33-, and 4.2-fold increases in resistance to diminazene, homidium, and quinapyramine, respectively. Both T. congolense IL 1180 and the resistant derivative were able to undergo cyclical development in Glossina morsitans centralis tsetse flies, producing hypopharyngeal infection rates of 40.0 and 39.8%, respectively.
Brain And Psyche: The Biology Of The Unconscious

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Particle Emissions from Animal Husbandry Source Activity Title : Particle Emissions from Animal Husbandry Dairy Cattle Other Cattle Fattening Pigs Sows Horses Laying Hens Broilers Nfr Codes : 4g 1 Activities Included

This chapter deals with primary particle emissions from ventilated animal housing systems. Due to the lack of reliable data, emissions from free-range animals, the storage and application of solid and liquid animal manures are not yet included in this chapter. Apart from industry, traffic and private households, the agricultural sector is a considerable contributor to emissions of particulate matter (PM). Agricultural activities such as plant and animal production on both farm sites and fields cause PM emissions. Although a reduction of PM emissions is observed for Europe, an increasing proportion of primary PM 10 emissions originates from agriculture including emissions from animal housing (Tab. 2.1). An earlier estimate by Klimont and Amann (2002) showed also a similar trend, i.e., European emissions from animal housing representing 2.7 and 4.3 % of total PM 10 in 1990 and 2000, respectively. Klimont and Amann (2002) estimated that the major source of PM emissions from housing are poultry and pig livestock operations, which are responsible for 57 % and 32 % of PM 10
Stoichiometric model and flux balance analysis for a mixed culture of Leptospirillum ferriphilum and Ferroplasma acidiphilum

The oxidation process of sulfide minerals in natural environments is achieved by microbial communities from the Archaea and Bacteria domains. A metabolic reconstruction of two dominant species, Leptospirillum ferriphilum and Ferroplasma acidiphilum, which are always found together as a mixed culture in this natural environments, was made. The metabolic model, composed of 152 internal reactions and 29 transport reactions, describes the main interactions between these species, assuming that both use ferrous iron as energy source, and F. acidiphilum takes advantage of the organic compounds secreted by L. ferriphilum for chemomixotrophic growth. A first metabolic model for a mixed culture used in bacterial leaching is proposed in this article, which pretends to represent the characteristics of the mixed culture in a simplified manner. It was evaluated with experimental data through flux balance analysis (FBA) using as objective function the maximization of biomass. The growth yields on ferrous iron obtained for each microorganism are consistent with experimental data, and the flux distribution obtained allows understanding of the metabolic capabilities of both microorganisms growing together in a bioleaching process. The model was used to simulate the growth of F. acidiphilum on different substrates, to determine in silico which compounds maximize cell growth, and which are essential. Knockout simulations were carried out for L. ferriphilum and F. acidiphilum metabolic models, predicting key enzymes of central metabolism. The results of this analysis are consistent with experimental data from literature, showing a robust behavior of the metabolic model. © 2014 American Institute of Chemical Engineers Biotechnol. Prog. , 31:307–315, 2015
Transgenic Cotton Plants Expressing Cry1Ia12 Toxin Confer Resistance to Fall Armyworm (Spodoptera frugiperda) and Cotton Boll Weevil (Anthonomus grandis)

Gossypium hirsutum (commercial cooton) is one of the most economically important fibers sources and a commodity crop highly affected by insect pests and pathogens. Several transgenic approaches have been developed to improve cotton resistance to insect pests, through the transgenic expression of different factors, including Cry toxins, proteinase inhibitors, and toxic peptides, among others. In the present study, we developed transgenic cotton plants by fertilized floral buds injection (through the pollen-tube pathway technique) using an DNA expression cassette harboring the cry1Ia12 gene, driven by CaMV35S promoter. The T0 transgenic cotton plants were initially selected with kanamycin and posteriorly characterized by PCR and Southern blot experiments to confirm the genetic transformation. Western blot and ELISA assays indicated the transgenic cotton plants with higher Cry1Ia12 protein expression levels to be further tested in the control of two major G. hirsutum insect pests. Bioassays with T1 plants revealed the Cry1Ia12 protein toxicity on Spodoptera frugiperda larvae, as evidenced by mortality up to 40% and a significant delay in the development of the target insects compared to untransformed controls (up to 30-fold). Also, an important reduction of Anthonomus grandis emerging adults (up to 60%) was observed when the insect larvae were fed on T1 floral buds. All the larvae and adult insect survivors on the transgenic lines were weaker and significantly smaller compared to the non-transformed plants. Therefore, this study provides GM cotton plant with simultaneous resistance against the Lepidopteran (S. frugiperda), and the Coleopteran (A. grandis) insect orders, and all data suggested that the Cry1Ia12 toxin could effectively enhance the cotton transgenic plants resistance to both insect pests.