Miracle-dz/UniFAR-FTUs huggingface dataset:
Health Implications of Lipedema: Analysis of Patient Questionnaires and Population-Based Matched Controls

We conducted a comparative study involving 39 female patients with lipedema and group-matched controls at a ratio of 1:5. The primary survey tool was the German Health Update (GEDA 2019/2020-EHIS) questionnaire, which was developed by the Robert Koch Institute (RKI), Germany. The secondary survey tool was the German Pain Questionnaire. The prevalence of hypertension (p = 0.041) and high blood lipids (p = 0.024) was lower in the lipedema group compared to the control group. General health and well-being indicators demonstrated lower overall health ratings (p < 0.001) and higher physiotherapy use in patients with lipedema (p = 0.016). Mental health assessment revealed higher depression prevalence and severity (p = 0.001), together with a lower number of close contacts (p = 0.032). Furthermore, patients with lipedema experienced higher levels of pain (p < 0.001) and more significant pain-related disability in daily activities (p < 0.001) than controls. Correlation analysis among patients with lipedema showed a positive correlation between pain severity and depressive symptoms (ρ = 0.612, p < 0.001) and a moderate positive correlation with impaired health-related quality of life (ρ = 0.418, p = 0.010). In summary, our findings highlight significant differences in health and well-being between patients with lipedema and matched controls, especially in overall, metabolic, and mental health, as well as pain perception. The findings emphasize the need for a validated lipedema-specific questionnaire and a multidisciplinary treatment approach with a combination of physical therapies, lifestyle adjustments, and psychological strategies.
Effect of Orchard Floor Management Practices on Fruit Production

Fruits are the demanding source of food in regard of nutrition and health. The demand for fruits is very much high in the market because of their unique taste and flavor. Fruits have a great potential butorchards are generally, infested with various types of annual, biennial and perennial weeds which compete with the fruit plants for nutrients, space, moisture, light and adversely affect growth, vigour, fruit set, flower initiation, yield, fruit quality and winter hardiness (Majek et al., 1993) and thereby directly reducing the productivity of fruit trees. Weeds also provide shelter to various pathogens by becoming an alternate or collateral host of invaded crops by a number of fungal, bacterial and viral diseases. It has been reported that about 36-42 per cent losses may occur due to inadequate management of weeds in apple (El-Metwally and Hafez, 2007).
Policy Research Working Paper 6410 Bank Bailouts , Competition , and the Disparate Effects for Borrower and Depositor Welfare

The Policy Research Working Paper Series disseminates the findings of work in progress to encourage the exchange of ideas about development issues. An objective of the series is to get the findings out quickly, even if the presentations are less than fully polished. The papers carry the names of the authors and should be cited accordingly. The findings, interpretations, and conclusions expressed in this paper are entirely those of the authors. They do not necessarily represent the views of the International Bank for Reconstruction and Development/World Bank and its affiliated organizations, or those of the Executive Directors of the World Bank or the governments they represent. This paper investigates how government interventions into banking systems such as blanket guarantees, liquidity support, recapitalizations, and nationalizations affect banking competition. This debate is important because the pricing of banking products has implications for borrower and depositor welfare. Exploiting data for 124 countries that witnessed different policy responses to 41 banking crises, and using difference-indifference estimations, the paper presents the following key results: (i) Government interventions reduce Lerner indices and net interest margins. This effect is robust to a battery of falsification and placebo tests, and the competitive response also cannot be explained by alternative forces. The competition-increasing effect on Lerner indices and net interest margins is also confirmed once the non-random assignment of interventions is accounted for using instrumental variable techniques that exploit exogenous variation in the electoral cycle and in the This paper—prepared as a background paper to the World Bank's World Development Report 2014: Managing Risk for Development—is a product of the Development Economics Vice Presidency. The views expressed in this paper are those of the authors and do not reflect the views of the World Bank or its affiliated organizations. Policy Research Working Papers are also posted on the Web at design of the regulatory architecture across countries. (ii) Consistent with theoretical predictions, the competition-increasing effect of government interventions is greater in more concentrated and less contestable banking sectors, but the effects are mitigated in more transparent banking systems. (iii) The competitive effects are economically substantial, remain in place for at least 5 years, and the interventions also coincide with an increase in zombie banks. The results therefore offer direct evidence of the mechanism by which government interventions contribute to banks' risk-shifting behavior as reported in recent studies on bank level runs via competition. (iv) Government interventions disparately affect bank …
Mobilization and export of millennial‐aged organic carbon by the Yellow River

A combined carbon isotope (13C and 14C) study was carried out to investigate the sources and fate of organic carbon (OC) transported by the Yellow River and preserved in the sediments of the Bohai and Yellow Seas. In 2015, the Yellow River delivered 3.14 × 1010 g C and 4.12 × 1010 g C of dissolved organic carbon (DOC) and particulate organic carbon (POC) to the Bohai Sea. Carbon isotope signatures revealed that the Yellow River transports millennial‐aged DOC and POC during all seasons. The values of δ13C‐DOC ranged from −24.7‰ to −28.8‰ in the river basin, and −21.0‰ to −27.0‰ in the lower reach. The 14C ages of DOC were 415–1690 yr before present (BP) in the river basin, and they were relatively constant seasonally (1320–1690 yr BP) in the lower reach of the river. In comparison, POC δ13C values in the river were less variable (−22.8‰ to −25.0‰), but much older in both the river basin (4960 ± 1690 yr BP) and in the lower reach (4040 ± 1050 yr BP). Calculations using a dual‐isotopic three‐end member model revealed that biomass OC derived from C3 plants was the major source of riverine DOC, contributing 65% ± 8% and 52% ± 2% in the river basin and lower reach seasonally. Pre‐aged soil OC and fossil OC from weathering contributed 21–42% and 6–14% of the DOC, respectively. In contrast, pre‐aged soil OC and fossil OC contributed 60–70% and 17–27% of POC, and biomass OC contributed a minor fraction (13% ± 7%) of riverine POC. Our results further revealed that aged riverine POC had a major influence on OC preservation in the delta and coastal sediments of the Bohai and Yellow Seas. The age of OC in surface sediments varied widely (1610–8275 yr) due to the influence of Yellow River input. Pre‐aged soil OC and fossil OC each contributed 32% ± 8% and 22% ± 14% of OC preserved in the sediments. We estimate that about 0.27 Mt yr−1 and 0.07 Mt yr−1 of pre‐aged soil OC and fossil OC accumulate in the surface sediments from POC delivered by the modern Yellow River, and 0.013 Mt yr−1 and 0.002 Mt yr−1 of pre‐aged soil OC and fossil OC enters the coastal DOC cycle from riverine DOC. The millennial‐aged OC delivered to coastal seas by the Yellow River therefore has profound impacts not only on carbon cycling and the carbon budget in the marginal sea, but also on coastal ecosystems and biogeochemical processes.
Polygenic Prediction of Cellular Immune Responses to Mumps Vaccine

In this report, we provide a follow-up analysis of a previously published genome-wide association study of host genetic variants associated with inter-individual variations in cellular immune responses to mumps vaccine. Here we report the results of a polygenic score (PGS) analysis showing how common variants can predict mumps vaccine response. We found higher PGS for IFNg;, IL-2, and TNFa; were predictive of higher post-vaccine IFNg; (p-value = 2e-6), IL-2 (p = 2e-7), and TNFa; (p = 0.004) levels, respectively. Control of immune responses after vaccination is complex and polygenic in nature. Our results suggest that the PGS-based approach enables better capture of the combined genetic effects that contribute to mumps vaccine-induced immunity, potentially offering a more comprehensive understanding than traditional single-variant GWAS. This approach will likely have broad utility in studying genetic control of immune responses to other vaccines and to infectious diseases.
Targeting CCNE1 amplified ovarian and endometrial cancers by combined inhibition of PKMYT1 and ATR

Ovarian cancers (OVCAs) and endometrial cancers (EMCAs) with CCNE1-amplification are often resistant to standard of care treatment and represent an unmet clinical need. Previously, synthetic-lethal screening identified loss of the CDK1 regulator, PKMYT1, as synthetically lethal with CCNE1-amplification. We hypothesized that CCNE1-amplification associated replication stress will be more effectively targeted by combining the PKMYT1 inhibitor, lunresertib (RP-6306), with the ATR inhibitor, camonsertib (RP-3500/RG6526). Low dose combination RP-6306 with RP-3500 synergistically increased cytotoxicity more in CCNE1 amplified compared to non-amplified cells. Combination treatment produced durable antitumor activity and increased survival in CCNE1 amplified patient-derived and cell line-derived xenografts. Mechanistically, low doses of RP-6306 with RP-3500 increase CDK1 activation more so than monotherapy, triggering rapid and robust induction of premature mitosis, DNA damage and apoptosis in a CCNE1-dependent manner. These findings suggest that targeting CDK1 activity by combining RP-6306 with RP-3500 is a novel therapeutic approach to treat CCNE1-amplifed OVCAs and EMCAs.
Mapping queen snapper (Etelis oculatus) suitable habitat in Puerto Rico using ensemble species distribution modeling

Queen snapper (Etelis oculatus) is of interest from an ecological and management perspective as it is the second most landed finfish species (by total pounds) as determined by Puerto Rico commercial landings (2010–2019). As fishing activities progressively expand into deeper waters, it is critical to gather data on deep-sea fish populations to identify essential fish habitats (EFH). In the U.S. Caribbean, the critically data-deficient nature of this species has made this challenging. We investigated the use of ensemble species distribution modeling (ESDM) to predict queen snapper distribution along the coast of Puerto Rico. Using occurrence data and terrain attributes derived from bathymetric datasets at different resolutions, we developed species distribution models unique to each sampling region (west, northeast, and southeast Puerto Rico) using seven different algorithms. Then, we developed ESDM models to analyze fish distribution using the highest-performing algorithms for each region. Model performance was evaluated for each ensemble model, with all depicting ‘excellent’ predictive capability (AUC > 0.8). Additionally, all ensemble models depicted ‘substantial agreement’ (Kappa > 0.7). We then used the models in combination with existing knowledge of the species’ range to produce binary maps of potential queen snapper distributions. Variable importance differed across spatial resolutions of 30 m (west region) and 8 m (northeast and southeast region); however, bathymetry was consistently one of the best predictors of queen snapper suitable habitat. Positive detections showed strong regional patterns localized around large bathymetric features, such as seamounts and ridges. Despite the data-deficient condition of queen snapper population dynamics, these models will help facilitate the analysis of their spatial distribution and habitat preferences at different spatial scales. Our results therefore provide a first step in designing long-term monitoring programs targeting queen snapper, and determining EFH and the general distribution of this species in Puerto Rico.
Preserved Gray Matter Volume in the Left Superior Temporal Gyrus Underpins Speech-in-Noise Processing in Middle-Aged Adults

Background: Neuroanatomical evidence suggests that behavioral speech-in-noise (SiN) perception and the underlying cortical structural network are altered by aging, and these aging-induced changes could be initiated during middle age. However, the mechanism behind the relationship between auditory performance and neural substrates of speech perception in middle-aged individuals remains unclear. In this study, we measured the structural volumes of selected neuroanatomical regions involved in speech and hearing processing to establish their association with speech perception ability in middle-aged adults. Methods: Sentence perception in quiet and noisy conditions was behaviorally measured in 2 different age groups: young (20-39 years old) and middle-aged (40-59-year-old) adults. Anatomical magnetic resonance images were taken to assess the gray matter volume of specific parcellated brain areas associated with speech perception. The relationships between these and behavioral auditory performance with age were determined. Results: The middle-aged adults showed poorer speech perception in both quiet and noisy conditions than the young adults. Neuroanatomical data revealed that the normalized gray matter volume in the left superior temporal gyrus, which is closely related to acoustic and phonological processing, is associated with behavioral SiN perception in the middle-aged group. In addition, the normalized gray matter volumes in multiple cortical areas seem to decrease with age. Conclusion: The results indicate that SiN perception in middle-aged adults is closely related to the brain region responsible for lower-level speech processing, which involves the detection and phonemic representation of speech. Nonetheless, the higher-order cortex may also contribute to age-induced changes in auditory performance.
Justice beliefs for self and others: Associations with positive and negative affectivity in African Americans and White Americans

Prior research has shown that a belief in personal justice (i.e., justice for self) is associated with better health and well-being, whereas a belief in justice more generally (i.e., justice for others) is unrelated. However, an emerging perspective is that racial differences may overlay the relationships between multidimensional beliefs about justice and indices of well-being. This includes that well-being among African Americans may be additionally supported by rejecting rather than endorsing some forms of believing in justice. In the present study, we consider racial similarities and differences in the links between beliefs about justice for self and others and emotional well-being. African Americans (N = 117) and White Americans (N = 188) completed measures of beliefs about justice for self and others, and also measures of dispositional tendencies towards experiencing positive and negative emotion (i.e., positive and negative affectivity). In both groups, beliefs about justice for the self were associated with greater positive affect and reduced negative affect. However, beliefs about justice for others were additionally associated with greater negative affect only among African Americans. The link between justice for others and negative affect among African Americans was not attributable to measurement or mean differences in justice beliefs across racial groups, or to socioeconomic differences. Results align with an emerging perspective that simultaneously endorsing and rejecting justice beliefs may be vital to preserving well-being for some racial minorities.
Combining social protection interventions for better food security: Evidence from female-headed households in Amhara region, Ethiopia

Ethiopia introduced its flagship poverty-targeted social protection program, the Productive safety net program (PSNP), in 2005 and Community-Based Health Insurance (CBHI) in 2011. Although both programs operate in several districts with some overlaps, evidence is scarce on how these large-scale programs jointly affect the food security of vulnerable groups. This study examines the impacts of a combination of these programs on food security outcomes among female-headed households in a chronically food-insecure and drought-prone district. Cross-sectional data were collected from 365 female-headed households selected through multi-stage sampling technique and analyzed using Inverse-probability-weighted regression adjustment (IPWRA) strategy to assess the effect of the programs on food security. The results show that while 63.6% of sample households are enrolled in CBHI and 48.8% are beneficiaries of PSNP’s conditional cash transfer (CCT) component, membership in both social protection programs was 38.9%. The IPWRA analysis finds that inclusion in the CCT combined with CBHI, on average, increased dietary diversity score by 0.918 (95% CI 0.779–1.057) and food consumption score by 0.576 (95% CI 0.464–0.688). It also reduced household food insecurity access scale by 8.658 (95% CI -9.775 – -7.541). In all assessments, a combination of CBHI and CCT always produced results of a larger magnitude than each of CBHI and CCT alone. The findings provide evidence of the potentials of integrating social protection programs to increase food security outcomes among the most vulnerable and marginalized groups in a developing country. In addition, the results have also useful implications to achieve sustainable development goals related to ending hunger and achieving food security among vulnerable groups.
Assessment of clinical pharmacist interventions using a web-based application in a Saudi Arabian Tertiary Hospital

Objectives: Medication-related problems are a top concern of clinical pharmacists. Medication-related problems can cause patient harm and increase the number of visits, hospital admissions, and length of hospital stay. The objective was to assess clinical pharmacy medication-related problem-related interventions in a tertiary care setting. Methods: A retrospective cohort study was conducted at King Fahad Armed Forces Hospital in Jeddah (Saudi Arabia) between June 2021 and June 2022. The data were extracted monthly from a new web-based Microsoft Excel application documenting medication-related problems during any stage of the medication use process. Results: A total of 5310 medication-related problem-related interventions in 1494 patients were performed. The departments associated with the highest frequency of medication-related problem-related interventions were the critical care unit (26.9%), intensive care unit (23.8%), anticoagulation clinic (17.1%), medical ward (11.3%), and nephrology unit (6.8%). The most common type of medication-related problem-related interventions included inappropriate dosage regimens (25.6%), monitoring drug effect or therapeutic drug monitoring (24.4%), requirement of additional drug therapy (21.9%), and inappropriate drug selection (14.1%). The proposed interventions were accepted by physicians in 97% of the incidents. The most frequent medication classes associated with medication-related problem-related interventions were cardiovascular agents (47.6%), antimicrobial agents (27.2%), and nutrition and blood substitute agents (11.4%). The most frequent medication groups associated with medication-related problem-related interventions were anticoagulants (25.6%) and antibiotics (25.2%). Conclusions: The current findings characterize the medication-related problem-related interventions addressed in clinical pharmacy at a tertiary care setting. The high rate of physician acceptance emphasizes the integral patient safety role of clinical pharmacy services.
Assessing the public discourse on Twitter: Reactions to the JUUL e-cigarettes ban in the United States

INTRODUCTION JUUL is a high-nicotine pod-based vaping device that is popular among adolescents and young adults. On 23 June 2022, the US Food and Drug Administration (FDA) denied authorization to market JUUL, and ordered JUUL Labs to remove products from the US market. The next day, a US federal appeals court temporarily suspended the ban. The mixed public discourse surrounding the FDA ban warrants further investigation. METHODS This study examined Twitter data to describe public reaction to these announcements. Posts containing terms ‘JUUL’ and/or ‘#JUUL’ (N=97548 unique tweets) were collected from 23 June to 3 July 2022, from Twitter’s Streaming Application Programming Interface (API). After removing retweets, we used an inductive approach to become familiar with the data, generated a codebook, and conducted a content analysis on a random sample of n=4000 tweets. RESULTS A total of 2755 (68.9%) tweets discussed JUUL in the context of the FDA ban. News (n=1425/2755; 51.7%) about the JUUL ban, government distrust (n=588; 21.3%), and individual rights (n=253; 9.2%) were the most prevalent themes. Less commonly discussed themes included inconsistencies between policies (n=174; 6.3%), mentions of switching to other products (n=162; 5.9%), smoking cessation (n=99; 3.6%), and craving for JUUL (n=94; 3.4%). Sentiment analysis of JUUL ban-related posts (n=2755) demonstrated that 1989 (72.2%) tweets were categorized as neutral, while anti-ban posts (n=566; 20.5%) were more prevalent than pro-ban posts (n=200; 7.3%). CONCLUSIONS Besides straightforward announcements of the JUUL ban and its suspension, Twitter posts discussed government distrust, individual rights, and policy inconsistencies. While most posts conveyed neutral sentiments, anti-ban posts were almost three times more prevalent than pro-ban posts. Our findings suggest that text-based social media platforms like Twitter may be an effective instrument to understand opinions, attitudes, and beliefs regarding the FDA’s JUUL ban.
Metabolites and MRI-Derived Markers of AD/ADRD Risk in a Puerto Rican Cohort

Objective Several studies have examined metabolomic profiles in relation to Alzheimer’s disease and related dementia (AD/ADRD) risk; however, few studies have focused on minorities, such as Latinos, or examined Magnetic-Resonance Imaging (MRI)-based outcomes. Methods We used multiple linear regression, adjusted for covariates, to examine the association between metabolite concentration and MRI-derived brain age deviation. Metabolites were measured at baseline with untargeted metabolomic profiling (Metabolon, Inc). Brain age deviation (BAD) was calculated at wave 4 (~ 9 years from Boston Puerto Rican Health Study (BPRHS) baseline) as chronologic age, minus MRI-estimated brain age, representing the rate of biological brain aging relative to chronologic age. We also examined if metabolites associated with BAD were similarly associated with hippocampal volume and global cognitive function at wave 4 in the BPRHS. Results Several metabolites, including isobutyrylcarnitine, propionylcarnitine, phenylacetylglutamine, phenylacetylcarnitine (acetylated peptides), p-cresol-glucuronide, phenylacetylglutamate, and trimethylamine N-oxide (TMAO) were inversely associated with brain age deviation. Taurocholate sulfate, a bile salt, was marginally associated with better brain aging. Most metabolites with negative associations with brain age deviation scores also were inversely associations with hippocampal volumes and wave 4 cognitive function. Conclusion The metabolites identifiedin this study are generally consistent with prior literature and highlight the role of BCAA, TMAO and microbially derived metabolites in cognitive decline.