Miracle-dz/UniFAR-FTUs huggingface dataset:
Brain-specific Restoration of Angiotensin II Corrects Renal Defects Seen in Angiotensinogen-deficient Mice*

Mice deficient for angiotensinogen (AGT), or other components of the renin-angiotensin system, show a high rate of neonatal mortality correlated with severe renal abnormalities including hydronephrosis, hypertrophy of renal arteries, and an impaired ability to concentrate urine. Although transgenic replacement of systemic or adipose, but not renal, AGT in AGT-deficient mice has previously been reported to correct some of these renal abnormalities, the tissue target for this complementation has not been defined. In the current study, we have used a novel transgenic strategy to restore the peptide product of the renin-angiotensin system, angiotensin II, exclusively in the brain of AGT-deficient mice and demonstrate that brain-specific angiotensin II can correct the hydronephrosis and partially correct renal dysfunction seen in AGT-deficient mice. Taken together, these results suggest that the renin-angiotensin system affects renal development and function through systemically accessible targets in the brain.
The Influence of Ambient Speech on Adult Speech Productions through Unintentional Imitation

Abstract This paper deals with the influence of ambient speech on individual speechproductions. A methodological framework is defined to gather the experimentaldata necessary to feed computer models simulating self-organisation in phonologicalsystems. Two experiments were carried out. Experiment 1 was run onFrench native speakers from two regiolects of Belgium: two from Liège and twofrom Brussels. When exposed to the way of speaking of the other regiolect vialoudspeakers, the speakers of one regiolect produced vowels that were significantlydifferent from their typical realisations, and significantly closer to the wayof speaking specific of the other regiolect. Experiment 2 achieved a replication ofthe results for 8 Mons speakers hearing a Liège speaker. A significant part of theimitative effect remained up to 10 min after the end of the exposure to the otherregiolect productions. As a whole, the results suggest that: (i) imitation occursautomatically and unintentionally, (ii) the modified realisations leave a memorytrace, in which case the mechanism may be better defined as ‘mimesis’ than as‘imitation’. The potential effects of multiple imitative speech interactions on soundchange are discussed in this paper, as well as the implications for a general theoryof phonetic implementation and phonetic representation.
A viral peptide can mimic an endogenous peptide for allorecognition of a major histocompatibility complex class I product

Alloreactive class I‐restricted T cells may recognize the class I structure alone, in association with a specific peptide, or with any stabilizing peptide. We havetested the role of endogenous peptides in the recognition of H2Kb molecules by two alloreactive cytolytic T lymphocyte (CTL) clones using the mutanttumor lineRMA‐S, which expresses its surface H‐2b molecules devoid of peptides and is not lysed by these two CTL clones. Empty H‐2b molecules on RMA‐S cells can be stabilized by binding exogenously added peptides. H‐2Kb−specific recognition of the RMA‐S cells by one of the CTL clones was restored by endogenous peptide extracts which only minimally stabilized H2Kb on the surface of RMA‐S cells, indicating the requirement for a specific peptide on a limited number of H2Kb molecules. In addition, one out of three peptides which greatly enhance the expression of H2Kb, the nucleoprotein peptide 52–59 from vesicular stomatitis virus (VSV), was also able to restore the lysis of RMA‐S cells by the clone. The recognition of a common motif by an alloreactive clone (H‐2k anti‐H‐2Kb) and virus‐specific Kb−restricted clones suggests that both H‐2k and H‐2b thymic environments allow selection of T cells capable of recognizing H2Kb+VSV and that tolerance to self, as would be the case in the (H‐2k x H‐2b)F1 mice, would partially delete the repertoire of antiviral T cells.
Numerical Analysis of Gain Saturation, Noise Figure, and Carrier Distribution for Quantum-Dot Semiconductor-Optical Amplifiers

The gain saturation behaviors and noise figure are numerically analyzed for quantum-dot semiconductor optical amplifiers (QD-SOAs). The carrier and photon distributions in the longitudinal direction as well as the photon energy dependent facet reflectivity are accounted in the rate equations, which are solved with output amplified spontaneous emission spectrum as iterative variables. The longitudinal distributions of the occupation probabilities and spectral-hole burning are presented for electrons in the excited and ground states of quantum dots. The saturation output power 19.7 dBm and device gain 20.6 dB are obtained for a QD-SOA with the cavity length of 6 mm at the bias current of 500 mA. The influences of the electron intradot relaxation time and the QD capture time on the gain spectrum are simulated with the relaxation time of 1, 30, and 60 ps and capture time of 1, 5, and 10 ps. The noise figure as low as 3.5 dB is expected due to the strong polarization sensitive spontaneous emission. The characteristics of gain saturation and noise figure versus input signal power for QD-SOAs are similar to that of semiconductor linear optical amplifiers with gain clamping by vertical laser fields.
Extended energy model for the low rate WPAN

Energy efficiency is a major concern in wireless sensor networks (WSNs) and as such power control policies play an essential component in maximizing a network's lifetime. Optimal power control policies provide the correct trade-off in balancing packet transmission reliability within the operational environment with expanded energy based on the wireless transceiver characteristics. In this paper, an extension of an energy model previously developed for the Chipcon CC2420, an IEEE802.15. 4trade device, is presented. The approach provides an extended energy model taking into account transitions energy cost between the Chipcon CC2420 operational states. The empirical testbed used to obtain the measured data is presented along with a summary of the measurements. A comparison is made between the extended model and the previous model to illustrate the importance of incorporating the transition energy requirements
Avenir d'une identité industrielle et gestion du ou des risque(s) : Pierre-Bénite (69) dans le couloir de la chimie

La commune de Pierre-Benite dans l'agglomeration lyonnaise se trouve au cœur du «couloir de la chimie» ou les usines jouxtent dangereusement les logements depuis un siecle. Longtemps attachee a ses industries, la municipalite ouvriere est aujourd'hui confrontee a la diversification de sa population. Au risque technologique s'ajoutent des perspectives economiques alarmantes.
Does Axial Limb Rotation Affect the Alignment Measurements in Deformed Limbs?

The long-term outcome of total knee arthroplasty and femoral or tibial osteotomy is related to the ability of the surgeon to achieve the desired alignment based on preoperative planning. This study evaluates the effect of axial rotation on measured tibiofemoral angles and the angle formed between the anatomic and mechanical axes of the femur in lower extremities with valgus and varus deformities. A comparison study of the measured tibiofemoral angles indicated a statistically significant effect in models with severe valgus or varus deformity when rotated 10° internally or externally. In the second part of the study, the measured angle between the anatomic and mechanical axes of the femur never varied by more than 1°, despite a 40° arc of rotation. The results of the study indicate the tibiofemoral angle measurements are more sensitive to axial limb rotation in lower extremities with valgus or varus deformity than are normally aligned limbs. In preoperative planning of total knee arthroplasty, the measured angle between the anatomic and mechanical axes of the femur is less effected by limb rotation, regardless of the degree of valgus or varus deformity.
Reliability Analysis of Lead-Free Solder Castellations

In this paper, the reliability of lead-free solder castellations is considered. The newly developed stress-dependent Engelmaier's solder fatigue model is utilized in this task. Based on this model, it is possible to interpret the thermal cycling test results. A very good agreement between the test results and the lifetime predictions is obtained. Using the lifetime prediction model, optimal solder castellation shape is investigated. Based on the findings, the fatigue life can be improved by up to 30% simply by solder pad length optimization. Further increment in lifetime length can be expected if the solder joint shape is optimized with the help of modeling tools presented here. Understanding how the crack propagates in solder material is vital if optimal lifetime behavior is expected.
Effect of bioactive filler content on mechanical properties and osteoconductivity of bioactive bone cement.

We took three types of bioactive bone cement (designated AWC, HAC, and TCPC), each with a different bioactive filler, and evaluated the influence of each filler on the mechanical properties and osteoconductivity of the cement. The cements consisted of bisphenol-a-glycidyl methacrylate-based (Bis-GMA based) monomers as an organic matrix, with a bioactive filler of apatite/wollastonite containing glass-ceramic (AW-GC) or sintered hydroxyapatite (HA) or beta-tricalcium phosphate (beta-TCP) powder. Each filler was mixed with the monomers in proportions of 50, 70, and 80% (w/w), giving a total of nine cement subgroups. The nine subgroups were designated AWC50, AWC70, AWC80, HAC50, HAC70, HAC80, TCPC50, TCPC70, and TCPC80. The compressive and bending strengths of AWC were found to be higher than those of HAC and TCPC for all bioactive filler contents. We also evaluated the cements in vivo by packing them into the intramedullary canals of rat tibiae. To compare the osteoconductivity of the cements, an affinity index was calculated for each cement; it equaled the length of bone in direct apposition to the cement, expressed as a percentage of the total length of the cement surface. Microradiographic examination up to 26 weeks after implantation revealed that AWC showed a higher affinity index than HAC and TCPC for each filler content although the affinity indices of all nine subgroups (especially the AWC and HAC subgroups) increased with time. New bone had formed along the AWC surface within 4 weeks, even in the cement containing AW-GC filler at only 50% (w/w); observation of the cement-bone interfaces using a scanning electron microscope showed that all the cements had directly contacted the bone. At 4 weeks the AWC had bonded to the bone via a 10 micron-thick reactive layer; the width of the layer, in which partly degraded AW-GC particles were seen, became slightly thicker with time. On the other hand, in the HAC- and TCPC-implanted tibiae, some particles on the cement surface were surrounded by new bone and partly absorbed or degraded. The results suggest that the stronger bonding between the inorganic filler and the organic matrix in the AWC cements gave them better mechanical properties. The results also indicate that the higher osteoconductivity of AWC was caused by the higher reactivity of the AW-GC powder on the cement surface.
Using NURBS Algorithms and Lyapunov Function to Comformational Stability for Improving Molecular Simulation Techniques

This investigation presents novel computer graphics and computational approaches for solving the challenges of computer-aided drug design (CADD). From NCBI' 97 reports, the most significant challenge is the docking procedure in CADD, and employs Lyapunov's stability theorem to decrease the number of binding sites for enhancing the docking performance. These novel techniques are significantly, based on the application of minimum energy and optimal geometry search strategies to prove the stability of protein-ligand interactions. This study applies the Lyapunov stability theorem to discuss the molecular orbit adjustment of molecular dynamics system equations during the molecular leave equilibrium point from the initial state with zero input and passing through infinite time t. Lyapunov's asymptotically stable theorem was developed to provide the stability of protein folding for drug docking computations. When the eigenvalue is smaller than the X-ray convergence value, the molecular framework is stable. When t tends toward infinity and its convergence rate is a negative ratio for Lyapunov exponentially function, the molecular system is close to the global minimum from various saddle points. In energy minimum, we have used the NURBS curves to accelerate the molecular docking system by the short route. This investigation studies the folding of various proteins and calculates the force field application; this is a novel technology that exhibits the protein structure with describe their function. In previous published studies, the WebDeGrator system was utilized to establish the molecular computer modeling for the docking process. Examples in protein folding kinetics and drug docking computations have been demonstrated, and this study successfully employs the Lyapunov function and molecular dynamics to support the determination of system stability. Finally, optimal solutions, molecular docking and protein folding kinetics are also discussed. This dissertation integrated various research fields to solve the problem of bioinformatics is an advanced manner. In the future, combining biology, information, system, and chemistry will be powerful strategies
The outcomes card. Development of a systems-based practice educational tool.

INTRODUCTION The Accreditation Council for Graduate Medical Education requires competence in systems-based practice (SBP) demonstrating understanding of complex interactions between systems of care and its impact upon care delivery. Patient safety is a useful vehicle to facilitate learning about these interactions. AIM Develop an educational tool, Outcomes Card (OC), to reinforce core concepts of SBP. SETTING Urgent Care Center at Louis Stokes Cleveland Department of Veterans Affairs Medical Center. PROGRAM DESCRIPTION Pilot study of an educational intervention for residents that included patient safety didactic sessions and analysis of 2 self-identified clinical cases using the OC. Residents entered the following information on the OC: case description, type of event (error, near miss, and/or adverse event), error type(s), systems, and system failures. PROGRAM EVALUATION Two reviewers independently analyzed 98 cards completed during 60 two-week trainee rotations (81.7% return rate). Interrater reliability for error types between residents and physician supervisor and between reviewers was excellent (kappa=0.88 and 0.95, respectively), and for system identification was good (kappa=0.66 and 0.68, respectively). The self-assessment survey (56.6% return rate) suggests that residents improved their knowledge of patient safety and had positive attitudes about the curriculum. DISCUSSION This pilot study suggests that OCs are feasible and reliable educational tools for enhancing competence in SBP.
Incidence and Distribution of Pediatric Sport-Related Injuries

Objective: To provide a critical review of the available literature on the descriptive epidemiology of pediatric sport-related injuries. Data Sources: MEDLINE (1966 to 2006) and SPORTDiscus (1975 to 2006) were searched to identify potentially relevant articles. A combination of medical subject headings and text words was used (epidemiology, children, adolescents, athletic injuries, sports, injury, and injuries). Additional references from the bibliographies of retrieved articles were also reviewed. Study Selection: Published research reports on the incidence and distribution of injury in children's and youth sports. Specific emphasis was placed on reviewing original studies, which report incidence rates (rate of injuries per unit athlete time). Forty-nine studies were selected for this review. Data Extraction: Data summarized include incidence of injury relative to who is affected by injury (sport, participation level, gender, and player position), where injury occurs (anatomical and environmental location), when injury occurs (injury onset and chronometry), and injury outcome (injury type, time loss, clinical outcome, and economic cost). Data Synthesis: There is little epidemiological data on injuries for some pediatric sports. Many of the studies retrieved were characterized by methodological short-comings and study differences that limit interpretation and comparison of findings across studies. Notwithstanding, the studies reviewed are encouraging and injury patterns that should be studied further with more rigorous study designs to confirm original findings and to probe causes of injury and the effectiveness of preventive measures. Conclusions: Incidence and severity of injury are high in some child and youth sports. This review will assist in targeting the relevant groups and in designing future research on the epidemiology of pediatric sports injuries. Well-designed descriptive and analytical studies are needed to identify the public health impact of pediatric sport injury.
A Study Comparing the Antisecretory Effect of TAK-438, a Novel Potassium-Competitive Acid Blocker, with Lansoprazole in Animals

Proton pump inhibitors (PPIs) are widely used for the treatment of acid-related diseases. However, several medical needs such as suppression of night-time acid secretion and rapid symptom relief remain unmet. In this study, we investigated the effects of 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel potassium-competitive acid blocker, on acid secretion in rats and dogs under various conditions, in comparison with the PPI lansoprazole [2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl] methyl]sulfinyl]-1H-benzimidazole], to characterize the antisecretory action of TAK-438. TAK-438 showed a more potent and longer-lasting inhibitory effect than lansoprazole on the histamine-stimulated gastric acid secretion in rats and dogs. A pharmacokinetic study in rats showed that TAK-438 accumulated and was retained in the gastric tissue for more than 24 h, unlike that in the plasma. TAK-438 showed significant antisecretory activity with or without cimetidine pretreatment, in contrast to lansoprazole, which did not show antisecretory activity after cimetidine pretreatment in rats. TAK-438 increased the pH of the gastric perfusate to 5.7 in an unstimulated condition, and this effect was maintained in the presence of subsequent histamine stimulation. On the other hand, lansoprazole also increased the pH in an unstimulated condition, but this effect diminished after histamine stimulation. These results indicated that TAK-438 exerted a more potent and longer-lasting antisecretory effect than lansoprazole through high accumulation and slow clearance from the gastric tissue. In addition, TAK-438 was unaffected by the gastric secretory state, unlike PPIs. Therefore, TAK-438 can provide a novel mechanism of action to improve the present PPI-based treatment of acid-related diseases.
Fast Head-Shoulder Proposal for Scare-Aware Pedestrian Detection

In this paper, we propose a scare-aware pedestrian detection method assisted by a fast head-shoulder detection process to pre-estimate the candidate regions that may contain target pedestrians. Based on the observation that human head-shoulder regions share relatively robust features, we propose a head-shoulder detector using six aggregated feature channels. Motivated by fact that visual appearance of the large-size and small-size pedestrians are significantly different, we apply a scale-aware detection mechanism. Two detectors are used, each focuses on the detection of either large-size or small-size pedestrians. The detection results from two detectors are weighted combined so that final detection results can be reinforced by a proper detector with respect to the size of the candidate pedestrian.
Smoking in adolescence as a predictor of early loss of periodontal attachment.

OBJECTIVES On the basis of information from studies of older adults, smoking is considered to be an important risk factor for periodontal disease. Examining periodontal loss of attachment among younger adults means a lower contribution from cumulative exposure to other environmental risk factors. The aim of this study was to examine the role of chronic exposure to cigarette smoking as a risk factor for greater prevalence and extent of periodontal loss of attachment among 26-year-old participants in a longstanding prospective cohort study. METHODS Loss of attachment (LOA) was measured at three sites per tooth in two randomly selected contralateral quadrants (one upper, one lower). Cigarette smoking history was obtained at ages 15, 18, 21 and 26, and used to categorise participants as "never-smokers", "ever-smokers", "long-term smokers" or "very longterm smokers". RESULTS Periodontal data were available for 914 Study members, among whom the prevalence of LOA of 4+mm was 19.4%. Among those who smoked at ages 15, 18, 21 and 26, it was 33.6%, and, after controlling for sex, selfcare and dental visiting, they were nearly three times as likely to have one or more sites with 4+mm LOA. CONCLUSIONS Chronic exposure to smoking is a strong predictor of periodontal disease prevalence in young adults.
A survey of ICT in post-primary schools

Information was obtained in conjunction with PISA 2003 about computer resources in schools in participating countries, and students' use of, and confidence with, computers. The ratio of students to computers in Ireland (9.0:1 was higher than the OECD average (6.2:1). The percentage of computers in schools connected to the Internet (67% was lower than the OECD average (79%), as was the percentage of computers with Local Area Network (LAN connectivity (36 compared to 69%). In Ireland and in other OECD countries, the socioeconomic composition of schools was only weakly related to these three indicators of school ICT resources. Some differences in computer resources were observed between school types. The student-computer ratio was higher in secondary schools than in community/comprehensive and vocational schools. It was also higher in single-sex than in mixed-sex schools. Levels of access of Irish students to computers at school and at home were similar to OECD averages. However, students' use of computers was comparatively low in Ireland, particularly in schools. One-third of students in Ireland (over twice the OECD average said that they never used a computer at school. Irish students also reported comparatively low levels of confidence in computer use, although gender differences favouring boys on these measures were smaller in Ireland than in many other countries. Information and Communications Technology (ICT plays an increasingly important role in work and in social and personal life, and is now of central importance for successful and critical participation in the knowledge society and has obvious implications for education systems. Three primary rationales for its inclusion in education have been proposed. First, pedagogically, the use of ICT is said to increase the breadth and nature of learning; second, socially, it is increasingly viewed as an essential life skill (akin to reading or mathematical
RDF Twig: accessing RDF graphs in XSLT

RDF is a powerful, standard way to represent metadata. XSLT is a powerful, standard way to transform documents. Unfortunately, it isn’t particularly easy to transform RDF graphs with XSLT. This paper describes a new strategy for making RDF amenable to XSLT processing. It introduces RDF Twig, a set of extension functions for Saxon and Xalan that provide a flexible methodology for accessing RDF graphs from XSLT. RDF Twig: accessing RDF graphs in XSLT Table of