Miracle-dz/UniFAR-FTUs huggingface dataset:
Blind adaptive multiuser detection based on affine projection algorithm

In this letter, we introduce a novel blind multiuser detector based on the affine projection algorithm (APA) for direct-sequence code-division multiple-access (DS-CDMA) systems. Computational complexities of least mean-squares (LMS), recursive least squares (RLS), Kalman, and APA-based blind multiuser detection algorithms are compared. The proposed technique has similar convergence and tracking properties as the RLS algorithm with much reduced computational cost. Simulation results are presented to compare our APA-based algorithm with the blind LMS, RLS, and Kalman schemes.
Spectral method for learning structural variations in graphs

The paper investigates the use of graph-spectral methods for learning the modes of structural variation in sets of graphs. Our approach is as follows. First, we vectorise the adjacency matrices of the graphs. Using a graph-matching method, we establish correspondences between the components of the vectors. Using the correspondences, we cluster the graphs using a Gaussian mixture model. For each cluster we compute the mean and covariance matrix for the vectorised adjacency matrices. We allow the graphs to undergo structural deformation by linearly perturbing the mean adjacency matrix in the direction of the modes of the covariance matrix. We demonstrate the method on sets of corner Delaunay graphs for 3D objects viewed from varying directions.
Nutritional and eating education improves knowledge and practice of patients with type 2 diabetes concerning dietary intake and blood glucose control in an outlying city of China

Abstract Objective To describe the knowledge, attitudes and practices of type 2 diabetics in Yakeshi City and to assess the effect of implementation of nutritional and eating education in enhancing knowledge and practices regarding a healthy diet. Design A questionnaire-based survey was conducted with 162 diabetics to determine their nutrition knowledge, attitudes and practices; fifty-four participants received nutritional and eating education for 6 months. Diabetes-related nutrition knowledge, awareness, practice accuracy, dietary intake and glycaemic control were assessed before and after education. Setting Yakeshi, a remote city in northern China. Subjects A total of 162 type 2 diabetics recruited from three hospitals, fifty-four of whom were selected randomly to receive education. Results Among the 162 respondents, most diabetics (75 %) considered that controlling diet was important in the methods of controlling blood glucose. Scores for knowledge, practices and overall KAP (knowledge–attitude–practice) were low, but scores for attitude were high. Participants with diabetes education experiences, practice duration over 1 year or high education level all had higher scores for KAP (P < 0·001, P < 0·05 and P < 0·001, respectively) than their counterparts. After education, patients’ nutrition knowledge, awareness and practice accuracy improved significantly (P < 0·05). The rates of patients with recommended daily intake of vegetables, grains and dairy were boosted (P < 0·05). Various nutrient intakes increased (P < 0·05) but not protein, Fe, Zn and Se. Significant improvements were also found in glycaemic control (P < 0·05). Conclusions Diabetics in Yakeshi had positive attitudes, but relatively poor nutrition knowledge and practices. Nutritional and eating education was effective in improving diabetics’ nutrition knowledge and practices, and this optimal practice helped them control blood glucose effectively.
Estimating the left boundary condition of coupled 1-D linear hyperbolic PDEs from right boundary sensing

In this paper, we develop an adaptive observer for n + 1 coupled first-order 1-D hyperbolic PDEs for estimation of unknown parameters appearing in the left boundary condition using only measurements at the right boundary. Proof of boundedness of the estimated parameters and sufficient conditions for convergence are offered and the result is demonstrated in a simulation.
Differential Expression of Insulin-Like Growth Factor-I Receptor on Human Bone Marrow-Derived Mesenchymal Stem Cells Induced by Tumor Necrosis Factor-α

Background: Cell-based therapy has been implicated in the treatment of liver diseases. Mesenchymal stem cells from various sources such as bone marrow are available. These cells are one of the major candidates in cell therapy. The production of insulin-like growth factor-I increases in the regenerating organ. The insulin-like growth factor-I in liver regeneration is effective after binding to insulin-like growth factor-I receptor. Objective: To test our hypothesis that tumor necrosis factor-α can stimulate mesenchymal stem cells to express insulin-like growth factor-I receptor. Methods: Bone marrow was aspirated from normal human donor after taking informed consent. Cells were isolated and cultured. Identification of cells was done by flowcytometry and functional tests. The fourth passage cells were treated with tumor necrosis factor-α at two doses of 1 and 10 ng/mL, and incubated for 2, 10, 24, and 48 hours. Insulin-like growth factor-I receptor gene expression was studied using real-time polymerase chain reaction. Results: Flowcytometry showed that the human bone marrow mesenchymal stem cells were positive for CD90 and negative for CD45 and CD80. The insulin-like growth factor-I receptor gene expression was increased in tumor necrosis factor-α treated in comparison with untreated cells. Conclusion: Treatment of human bone marrow-derived mesenchymal stem cells with tumor necrosis factor-α increases gene expression of insulin-like growth factor-I receptor. This finding may be used for increasing the effectiveness of stem cell therapy in those with acute hepatic failure.
Retrospective duration estimations for variant and invariant events in field situations

Retrospective duration estimations were investigated immediately after participation in everyday, naturalistic activities which ranged between 4 seconds and 80 minutes in length. Those events which remain invariant over time were more accurately estimated than events which are variable in length. Support was found for Vierordt's Law (1868); short events were overestimated and longer events were underestimated. Imagery-rehearsal had no significant effect on duration estimation. Age of participants was not related to duration estimations. Women gave reliably longer estimations than men, but no reliable differences were found for gender when estimations were based on events which were frequently experienced in familiar settings. Confidence-accuracy correlations were reliable for judgements of invariant events but not for variant events. Copyright © 2000 John Wiley & Sons, Ltd. Language: en
Development and Characterization of New Single Nucleotide Polymorphism Markers from Expressed Sequence Tags in Common Carp (Cyprinus carpio)

The common carp (Cyprinus carpio) is an important aquaculture fish worldwide but only limited single nucleotide polymorphism (SNP) markers are characterized from expressed sequence tags (ESTs) in this species. In this study, 1487 putative SNPs were bioinformatically mined from 14,066 online ESTs mainly from the European common carp, with the occurrence rate of about one SNP every 173 bp. One hundred and twenty-one of these SNPs were selected for validation using PCR fragment sequencing, and 48 out of 81 primers could amplify the expected fragments in the Chinese common carp genome. Only 26 (21.5%) putative SNPs were validated, however, 508 new SNPs and 68 indels were identified. The ratios of transitions to transversions were 1.77 for exon SNPs and 1.05 for intron SNPs. All the 23 SNPs selected for population tests were polymorphic, with the observed heterozygosity (Ho) ranging from 0.053 to 0.526 (mean 0.262), polymorphism information content (PIC) from 0.095 to 0.357 (mean 0.246), and 21 SNPs were in Hardy–Weinberg equilibrium. These results suggest that different common carp populations with geographic isolation have significant genetic variation at the SNP level, and these new EST-SNP markers are readily available for genetics and breeding studies in common carp.
Lying to Get a Date: The Effect of Facial Physical Attractiveness on the Willingness to Deceive Prospective Dating Partners

This research explored the extent to which people use deception to initiate a date with opposite-sex prospects who varied in facial physical attractiveness. Participants reviewed profiles of prospective dates varying in facial attractiveness, described their own personal characteristics to the prospective dates (study 1), and rated their willingness to lie to make themselves appear to be more desirable to each prospect (study 2). Both men and women deceptively altered their self-presented expressivity and love attitudes to more attractive prospects (study 1), and reported being more willing to lie about their personal appearance, personality traits, income, past relationship outcomes, career skills and intelligence to prospective dates who were higher in facial physical attractiveness, compared with prospective dates who were lower in facial physical attractiveness (study 2). No sex-differences in the willingness to use deceptive self-presentational tactics were found. A strong positive correlation was found between people’s willingness to lie about a specific personal dimension and the extent to which physically attractive individuals differed from other people on that dimension. Thus, it appears that people endeavor to lie to physically attractive people in ways that maximize their similarity with the attractive target.
From Preferences to Experiences: Valuing the Intangible Victim Costs of Crime

An important part of the costs of crime are intangible victim costs; that is, the effects on individual well-being. Economists tend to value such costs by asking people what they would be willing to pay to avoid them (either in money terms or by giving up something else of value, like life expectancy). However, psychological research has shown that such preferences are not a very good guide to how various events impact on well-being. Recent developments in the measurement of well-being as it is experienced provide promising alternatives to preference-based methods and we discuss how these methods could be developed further to provide more robust estimates of intangible costs of crime.
Work–family conflict/facilitation and the role of workplace supports for U.S. Hispanic professionals

This study investigated the relationship between work–family conflict/facilitation (WFC/F) and the perception of psychological contract fairness by Hispanic business professionals. In addition, this study examined the effects of WFC/F as a mediator of the relationship between workplace supports and psychological contract fairness. A survey of 1165 Hispanic business professionals, from the United States, contained reports their experience of work-to-family conflict and facilitation, perception of the fairness of their psychological contract, and the availability of four types of workplace supports: formal work–family policies, supervisor support, work climate for family, and job characteristics. Results revealed that individuals who experience low conflict and high facilitation in the direction of work-to-family are more likely to report their perception of the psychological contract to be fair. Work–family conflict/ facilitation mediated the relationship between the workplace supports and psychological contract fairness for supervisor support, work climate for family, and job characteristics. There was a direct relationship between the availability of formal workplace supports and psychological contract fairness. Implications for theory and practice are also noted. Copyright © 2009 John Wiley & Sons, Ltd.
A randomized trial of bevacizumab for newly diagnosed glioblastoma.

BACKGROUND Concurrent treatment with temozolomide and radiotherapy followed by maintenance temozolomide is the standard of care for patients with newly diagnosed glioblastoma. Bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor A, is currently approved for recurrent glioblastoma. Whether the addition of bevacizumab would improve survival among patients with newly diagnosed glioblastoma is not known. METHODS In this randomized, double-blind, placebo-controlled trial, we treated adults who had centrally confirmed glioblastoma with radiotherapy (60 Gy) and daily temozolomide. Treatment with bevacizumab or placebo began during week 4 of radiotherapy and was continued for up to 12 cycles of maintenance chemotherapy. At disease progression, the assigned treatment was revealed, and bevacizumab therapy could be initiated or continued. The trial was designed to detect a 25% reduction in the risk of death and a 30% reduction in the risk of progression or death, the two coprimary end points, with the addition of bevacizumab. RESULTS A total of 978 patients were registered, and 637 underwent randomization. There was no significant difference in the duration of overall survival between the bevacizumab group and the placebo group (median, 15.7 and 16.1 months, respectively; hazard ratio for death in the bevacizumab group, 1.13). Progression-free survival was longer in the bevacizumab group (10.7 months vs. 7.3 months; hazard ratio for progression or death, 0.79). There were modest increases in rates of hypertension, thromboembolic events, intestinal perforation, and neutropenia in the bevacizumab group. Over time, an increased symptom burden, a worse quality of life, and a decline in neurocognitive function were more frequent in the bevacizumab group. CONCLUSIONS First-line use of bevacizumab did not improve overall survival in patients with newly diagnosed glioblastoma. Progression-free survival was prolonged but did not reach the prespecified improvement target. (Funded by the National Cancer Institute; ClinicalTrials.gov number, NCT00884741.).
Expression of imprinted genes is aberrant in deceased newborn cloned calves and relatively normal in surviving adult clones

Cattle are the species used most frequently for the development of assisted reproductive technologies, such as nuclear transfer. Cattle cloning can be performed by a large number of laboratories around the world, and the efficiency of nuclear transfer in cattle is the highest among all species in which successful cloning has been achieved. However, an understanding of the expression of imprinted genes in this important species is lacking. In the present study, real time reverse transcription polymerase chain reaction (RT‐PCR) was utilized to quantify the expression of the bovine Igf2, Igf2r, and H19 genes in eight major organs (brain, bladder, heart, kidney, liver, lung, spleen, and thymus) of somatic cell cloned calves that died shortly after birth, in three tissues (skin, muscle, and liver) of healthy clones that survived to adulthood, and in corresponding tissues of control animals from natural reproduction. We found that, deceased bovine cloned calves exhibited abnormal expression of all three genes studied in various organs. Large variations in the expression levels of imprinted genes were also seen among these clones, which were produced from the same genetic donor. In surviving adult clones, however, the expression of these imprinted genes was largely normal, except for the expression of the Igf2 gene in muscle, which was highly variable. Our data showed disruptions of expression of imprinted genes in bovine clones, which is possibly due to incomplete reprogramming of donor cell nuclei during nuclear transfer, and these abnormalities may be associated with the high neonatal mortality in cloned animals; clones that survived to adulthood, however, are not only physically healthy but also relatively normal at the molecular level of those three imprinted genes. Mol. Reprod. Dev. © 2005 Wiley‐Liss, Inc.
Delineating the mechanism by which selenium deactivates Akt in prostate cancer cells

The up-regulation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway is prevalent in many cancers. This phenomenon makes PI3K and Akt fruitful targets for cancer therapy and/or prevention because they are mediators of cell survival signaling. Although the suppression of phospho-Akt by selenium has been reported previously, little information is available on whether selenium modulates primarily the PI3K-phosphoinositide-dependent kinase 1 (PDK1) side of Akt phosphorylation or the phosphatase side of Akt dephosphorylation. The present study was aimed at addressing these questions in PC-3 prostate cancer cells which are phosphatase and tensin homologue-null. Our results showed that selenium decreased Akt phosphorylation at Thr308 (by PDK1) and Ser473 (by an unidentified kinase); the Thr308 site was more sensitive to selenium inhibition than the Ser473 site. The protein levels of PI3K and phospho-PDK1 were not affected by selenium. However, the activity of PI3K was reduced by 30% in selenium-treated cells, thus discouraging the recruitment of PDK1 and Akt to the membrane due to low phosphatidylinositol-3,4,5-trisphosphate formation by PI3K. Consistent with the above interpretation, the membrane localization of PDK1 and Akt was significantly diminished as shown by Western blotting. In the presence of a calcium chelator or a specific inhibitor of calcineurin (a calcium-dependent phosphatase), the suppressive effect of selenium on phospho-Akt(Ser473) was greatly reduced. The finding suggests that selenium-mediated dephosphorylation of Akt via calcineurin is likely to be an additional mechanism in regulating the status of phospho-Akt. [Mol Cancer Ther 2006;5(2):246–52]
Magnetic nanoparticle-mediated hyperthermia therapy induces tumour growth inhibition by apoptosis and Hsp90/AKT modulation

Abstract Purpose: We have evaluated the hyperthermia efficacy of oleic acid-functionalised Fe3O4 magnetic nanoparticles (MN-OA) under in vivo conditions and elucidated the underlying mechanism of tumour growth inhibition. Materials and methods: The efficacy and mechanism of tumour growth inhibition by MN-OA-mediated magnetic hyperthermia therapy (MHT) was evaluated in a murine fibrosarcoma tumour model (WEHI-164) using techniques such as TUNEL assay, Western blotting (WB), immunofluorescence (IF) staining and histopathological examination. In addition, bio-distribution of MN-OA in tumour/other target organs and its effect on normal organ function were studied by Prussian blue staining and serum biochemical analysis, respectively. Results: MN-OA-induced MHT resulted in significant inhibition of tumour growth as determined by measurement of tumour volume, as well as by in vivo imaging of tumour derived from luciferase-transfected WEHI-164 cells. Histopathology analysis showed presence of severe apoptosis and reduced tumour cells proliferation, which was further confirmed by TUNEL assay, reduced expression of Ki-67 and enhanced level of cleaved caspase-3, in tumours treated with MHT. Moreover, expression of heat stress marker, Hsp90 and its client protein, AKT/PKB was reduced by ∼50 and 80%, respectively, in tumours treated with MHT as studied by WB and IF staining. Serum analysis suggested insignificant toxicity of MN-OA (in terms of liver and kidney function), which was further correlated with minimal accumulation of MN-OA in target organs. Conclusions: These results suggest the involvement of apoptosis and Hsp90/AKT modulation in MN-OA-mediated MHT-induced tumour growth inhibition.
Developments in the management of uveal melanoma

Uveal melanomas threaten visual loss, enucleation, and death from metastatic disease. Most patients present because of symptoms, but failures of detection and diagnosis still occur commonly. Treatments aimed at avoiding enucleation include: plaque, proton beam or stereotactic radiotherapy; trans‐scleral or trans‐retinal local resection; and transpupillary thermotherapy. Increasingly, different modalities are being used in combination. The ocular outcomes are related to tumour size, location, spread and cell type. Metastatic disease occurs in many patients and is related to factors such as tumour dimensions, ciliary body involvement, cell type, extravascular matrix patterns and cytogenetics. Abnormalities related to chromosomes 3, 6 and 8 are strongly related to tumour behaviour, for the first time enabling survival probability to be estimated with a high degree of reliability in an individual patient. This enables high‐risk individuals to be targeted for screening while providing reassurance to those with a minimal chance of developing metastatic disease. Such targeting would allow selection of patients for adjuvant systemic therapy, should a suitable treatment become available, and would also facilitate the evaluation of such treatment by increasing the statistical power of any randomized prospective study. The high mortality in patients with monosomy 3 melanoma suggests that in these patients ocular treatment is only palliative. Cytogenetic studies suggest that some melanomas may never develop any metastatic potential and if these impressions are confirmed by further studies, then in these patients the main priority of treatment would be to conserve vision.
Role of CaCO3° Neutral Pair in Calcium Carbonate Crystallization

The molecular structure of the units that get incorporated into the nuclei of the crystalline phase and sustain their growth is a fundamental issue in the pathway from a supersaturated solution to the formation of crystals. Using a fluorescent dye we have recorded the variation of the pH value in time along a gel where CaCl2 and NaHCO3 counter-diffuse to crystallize CaCO3. The same pH–space–time distribution maps were also computationally obtained using a chemical speciation code (phreeqc). Using data arising from this model we investigated the space-time evolution of the activity of the single species (ions and ion pairs) involved in the crystallization process. Our combined results suggest that, whatever the pathway from solution to crystals, the neutral pair CaCO3° is a key species in the CaCO3 precipitation system.
Hierarchical Processing in Seven-Month-Old Infants

Hierarchical structures are crucial to many aspects of cognitive processing and especially for language. However, there still is little experimental support for the ability of infants to learn such structures. Here, we show that, with structures simple enough to be processed by various animals, seven-month-old infants seem to learn hierarchical relations. Infants were presented with an artificial language composed of “sentences” made of three-syllable “words. ” The syllables within words conformed to repetition patterns based on syllable tokens involving either adjacent repetitions (e.g., dubaba) or nonadjacent repetitions (e.g., dubadu). Importantly, the sequence of word structures in each sentence conformed to repetition patterns based on word types (e.g., aba-abb-abb). Infants learned this repetition pattern of repetition patterns and thus likely a hierarchical pattern based on repetitions, but only when the repeated word structure was based on adjacent repetitions. While our results leave open the question of which exact sentence-level pattern infants learned, they suggest that infants embedded the word-level patterns into a higher-level pattern and thus seemed to acquire a hierarchically embedded pattern.