Miracle-dz/UniFAR-FTUs huggingface dataset:
Exercise Prevents the Accumulation of Triglyceride-Rich Lipoproteins and Their Remnants Seen When Changing to a High-Carbohydrate Diet

We tested the hypothesis that daily aerobic exercise opposes the fasting hypertriglyceridemia and exaggerated postprandial lipemia observed after substituting dietary fat with carbohydrate. Eight healthy postmenopausal women aged 51 to 66 years consumed the same high-fat mixed meal on 3 occasions: (1) after 3 days on a low-carbohydrate diet (35%, 50%, and 15% energy from carbohydrate, fat, and protein, respectively); (2) after 3 days on an isoenergetic high-carbohydrate diet (corresponding values 70%, 15%, and 15%); and (3) after 3 days on the same high-carbohydrate diet with 60 minutes of brisk walking daily. Plasma triglycerides were higher after the high-carbohydrate diet than after the low-carbohydrate diet: fasting, 1.58±0.19 versus 0.96±0.12 mmol/L, respectively; 6-hour postprandial area under concentration versus time curve, 13.74±1.57 versus 10.12±1.15 (mmol/L)×hour, respectively (both P <0.01). In the fasted and postprandial states, concentrations of apolipoproteins B-48 and B-100 in the triglyceride-rich lipoprotein fraction were significantly higher after the high-carbohydrate diet, as was the concentration of remnant-like lipoprotein particle cholesterol (a measure of lipoprotein remnants). These carbohydrate-induced increases in the number of circulating triglyceride-rich particles and their remnants were abolished when subjects had exercised daily during the high-carbohydrate diet.
Automated Method for Tracking Individual Red Blood Cells Within Capillaries to Compute Velocity and Oxygen Saturation

Objective: The authors present a new method to track individual red blood cells (RBCs) as they move through capillaries. This method uses a recently developed Measurement and Analysis System for Capillary Oxygen Transport (MASCOT) and the concept of space–time images to track RBCs between consecutive frames of video recordings of the microcirculation.
Tea-Time museum: Croquet as a browsing and searching environment for digital libraries

In this paper, we describe a research project in the planning stage, called a Tea-Time Museum, that aims at exploration of a new environment for content browsing and multi-user collaboration based on contents. Tea (currently, Croquet) is a next generation collaborative 3D user environment proposed by Reed et al. (2002). Although Croquet is implemented as a collaborative 3D environment for users, new constructs, such as the notion of portals are considered to be key technologies for constructing the next generation digital libraries. We provide our interpretations of Croquet constructs from the view point of hypermedia processing, which will be useful for using Croquet as a basis for constructing a new method of content browsing/searching and a new collaborative (social) search based on Web content.
Cryptanalysis and Improvement of Akleylek et al.'s cryptosystem

Akleylek et al. [S. Akleylek, L. Emmungil and U. Nuriyev, A mod ified algorithm for peer-to-peer security, journal of Appl. Comput. Math., vol. 6(2), pp.258-264, 2007. ], introduced a modified public-key encryption scheme with steganographic approach for security in peer-to-peer (P2P) networks. In this cryptosystem, Akleylek et al. attempt to increase security of the P2P networks by mixing ElGamal cryptosystem with knapsack problem. In this paper, we present a ciphertext-only attack against their system to recover message. In addition, we show that for their scheme completeness property is not holds, and therefore, the receiver cannot uniquely decrypts messages. Furthermore, we also show that this system is not chosen-ciphertext secure, thus the proposed scheme is vulnerable to man-in-the-middle-attack, one of the most pernicious attacks against P2P networks. Therefore, this scheme is not suitable to implement in the P2P networks. We modify this cryptosystem in order to increase its security and efficiency. Our construction is the efficient CCA2-secure variant of the Akleylek et al.'s encryption scheme in the standard model, the de facto security notion for public-key encryption schemes.
Heparin-induced thrombocytopenia: recommendations for optimal use of recombinant hirudin.

Recombinant hirudins have a definite role in the treatment of patients with heparin-induced thrombocytopenia (HIT). The most important adverse effects are haemorrhages and the induction of antihirudin antibodies. Major haemorrhages were not significantly increased in patients with HIT compared with a historical control group, but prospective data comparing hirudin and heparinoids such as danaparoid are lacking. The definition of the optimal method for monitoring and the availability of an antidote for hirudin would probably increase safety with this drug. To date, haemofiltration using high-flux filter systems is the only way to remove an overdosage of hirudin from the circulation. In patients with renal impairment requiring hirudin treatment, it therefore seems safer to start with a low dose that is subsequently adjusted according to the activated partial prothromboplastin time or ecarin clotting time. Even in special circumstances, such as cardiopulmonary bypass or dialysis, hirudins can be applied successfully if care is taken to monitor their effects meticulously. There are many other indications in which hirudins have shown feasibility (e.g. acute coronary syndromes) but available data preclude definite conclusions.
Sessions, from Types to Programming Languages

We introduce basic language constructs and a type discipline as a foundation of structured communication-based concurrent programming. The constructs, which are easily translatable into the summation-less asynchronous π-calculus, allow programmers to organise programs as a combination of multiple flows of (possibly unbounded) reciprocal interactions in a simple and elegant way, subsuming the preceding communication primitives such as method invocation and rendez-vous. The resulting syntactic structure is exploited by a type discipline a la ML, which offers a high-level type abstraction of interactive behaviours of programs as well as guaranteeing the compatibility of interaction patterns between processes in a well-typed program. After presenting the formal semantics, the use of language constructs is illustrated through exampl s, and the basic syntactic re ults of the type discipline are established. Implementation concerns are also addressed.
Comparative study of the efficacy of oral ketoconazole with intra-lesional meglumine antimoniate (Glucantime) for the treatment of cutaneous leishmaniasis

BACKGROUND: Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease caused by a range of Leishmania species. Many treatment modalities have been proposed, although pentavalent antimonials are still considered to be the first-line treatment of CL. However, due to the high cost and adverse effects of antimonials, as well as an increase in the number of resistant strains of CL to antimonials, this study was conducted to compare the efficacy of oral ketoconazole with intralesional meglumine antimoniate (Glucantime, Specia, Paris, France) for the treatment of CL. METHODS: A total of 96 patients with CL were enrolled in the study. The diagnosis of CL was confirmed parasitologically using direct skin smears or skin biopsies. The patients were randomly allocated to two treatment groups. Group A (64 patients) was treated with ketoconazole 600 mg/day for adults and 10 mg/kg per day for children for 30 days. Group B (32 patients) was treated with 6–8 biweekly intra-lesional injections of meglumine antimoniate (Glucantime). Both groups were followed for 6 months after termination of treatment. RESULTS: The results showed complete clinical cure in 89% of cases in Group A (treated with oral ketoconazole) and 72% of cases in Group B (treated with intra-lesional Glucantime). This difference was statistically significant ( p < 0.05). No significant side effects were observed in either treatment group. CONCLUSION: Oral ketoconazole can be an effective treatment modality in CL, especially in children afflicted with this disease.
FPGA Design and Implementation of Matrix Multiplication Architecture by PPI-MO Techniques

Matrix multiplication is the kernel operation used in many transform, image and discrete signal processing application. We develop new algorithms and new techniques for matrix multiplication on configurable devices. In this paper, we have proposed three designs for matrix-matrix multiplication. These design reduced hardware complexity, throughput rate and different input/output data format to match different application needs. These techniques have been designed implementation on Virtex-4 FPGA. We have synthesized the proposed designs and the existing design using Synopsys tools. Interestingly, the proposed parallel-fixed-input and multiple-output (PPI-MO) structure consumes 40% less energy than other two proposed structures and 70% less energy than the existing structure.
Playful expressions of one-year-old chimpanzee infants in social and solitary play contexts

Knowledge of the context and development of playful expressions in chimpanzees is limited because research has tended to focus on social play, on older subjects, and on the communicative signaling function of expressions. Here we explore the rate of playful facial and body expressions in solitary and social play, changes from 12- to 15-months of age, and the extent to which social partners match expressions, which may illuminate a route through which context influences expression. Naturalistic observations of seven chimpanzee infants (Pan troglodytes) were conducted at Chester Zoo, UK (n = 4), and Primate Research Institute, Japan (n = 3), and at two ages, 12 months and 15 months. No group or age differences were found in the rate of infant playful expressions. However, modalities of playful expression varied with type of play: in social play, the rate of play faces was high, whereas in solitary play, the rate of body expressions was high. Among the most frequent types of play, mild contact social play had the highest rates of play faces and multi-modal expressions (often play faces with hitting). Social partners matched both infant play faces and infant body expressions, but play faces were matched at a significantly higher rate that increased with age. Matched expression rates were highest when playing with peers despite infant expressiveness being highest when playing with older chimpanzees. Given that playful expressions emerge early in life and continue to occur in solitary contexts through the second year of life, we suggest that the play face and certain body behaviors are emotional expressions of joy, and that such expressions develop additional social functions through interactions with peers and older social partners.
Wake-Up Stroke: Current Understanding

Abstract Patients with wake-up strokes account for approximately 1 in 5 individuals presenting with an acute ischemic stroke. However, they are commonly excluded from acute stroke treatment. This article reviews the current understanding of wake-up strokes. A comparison of wake-up and awake-onset strokes demonstrated that they are physiologically, clinically, and radiologically similar. Use of advanced CT and MRI techniques may help extend acute stroke treatment options to patients with wake-up stroke.
Induction of Oral Tolerance to HSP60 or an HSP60-Peptide Activates T Cell Regulation and Reduces Atherosclerosis

Objective—HSP60-specific T cells contribute to the development of the immune responses in atherosclerosis. This can be dampened by regulatory T cells activated via oral tolerance induction, and we explored the effect of oral tolerance induction to HSP60 and the peptide HSP60 (253 to 268) on atherosclerosis. Methods and Results—HSP60 and HSP60 (253 to 268) were administered orally to LDLr−/− mice before induction of atherosclerosis and resulted in a significant 80% reduction in plaque size in the carotid arteries and in a 27% reduction in plaque size at the aortic root. Reduction in plaque size correlated with an increase in CD4+CD25+Foxp3+ regulatory T cells in several organs and in an increased expression of Foxp3, CD25, and CTLA-4 in atherosclerotic lesions of HSP60-treated mice. The production of interleukin (IL)-10 and transforming growth factor (TGF)-&bgr; by lymph node cells in response to HSP60 was observed after tolerance induction. Conclusion—Oral tolerance induction to HSP60 and a small HSP60-peptide leads to an increase in the number of CD4+CD25+Foxp3+ regulatory T cells, resulting in a decrease in plaque size as a consequence of increased production of IL-10 and TGF-&bgr;. We conclude that these beneficial results of oral tolerance induction to HSP60 and HSP60 (253 to 268) may provide new therapeutic approaches for the treatment of atherosclerosis.
Reduced Fertility After Cesarean Delivery: A Maternal Choice

OBJECTIVE: To explore the association between mode of delivery and subsequent fertility. METHODS: Deliveries registered in the Medical Birth Registry of Norway were linked to mothers through national identification numbers. The study population was 596,341 women who had their first delivery during 1967–1996, and who were followed up through 2003. We compared rates of continuation to a subsequent birth according to mode of previous delivery (cesarean compared with vaginal). RESULTS: If the first child survived the first year of life, cesarean delivery was associated with a significantly reduced probability of a second birth (relative risk [RR] 0.82, 95% confidence interval [CI] 0.81–0.83 during 1967–1981, and RR 0.88, 95% CI 0.88–0.89 during 1982–1996). Following a stillbirth or an infant loss, the association was less strong during 1967–1981 (RR 0.93, 95% CI 0.89–0.97) and no longer significant during 1982–1996 (RR 1.00, 95% CI 0.97–1.03). A similar pattern was observed from the second to the third birth and in subgroup analyses of women with preeclampsia or breech presentation and in an obstetric low-risk group. CONCLUSION: Cesarean delivery was more strongly associated with reduced fertility if the infant survived than if it was stillborn or died. This suggests that the reduced fertility was to a large degree voluntary and not related to the indication, nor to any physical consequence, of the cesarean delivery. LEVEL OF EVIDENCE: II
Interactions of Andronov-Hopf and Bogdanov-Takens bifurcations

A codimension-three bifurcation, characterized by a pair of purely imaginary eigenvalues and a nonsemisimple double zero eigenvalue, arises in the study of a pair of weakly coupled nonlinear oscillators with Z_2 + Z_2 symmetry. The methodology is based on Arnold's ideas of versal deformations of matrices for the linear analysis, and Poincar\'e normal forms for the nonlinear analysis of the system. The stratified subvariety of primary bifurcations of codimensions one and two is identified in the parameter space. The analysis reveals different types of solutions in the state space, including equilibria, limit cycles, invariant tori and the possibility of homoclinic chaos. A mechanism is identified for energy transfer without strong resonance between two oscillation modes with widely separated frequencies.
The role of decitabine in the treatment of myelodysplastic syndromes

Supportive care with red cell and platelet transfusions and use of growth factors has long been the standard of care for patients with myelodysplastic syndromes (MDS) ineligible for stem cell transplantation. Although these measures improve quality of life, their impact on the natural history of the disease is questionable. Recently, three new agents have been approved for the treatment of MDS. These include: 5-azacytidine, lenalidomide and, more recently, 5-aza-2´-deoxycytidine (decitabine). Decitabine is a hypomethylating agent that is incorporated into DNA and forms irreversible covalent adducts with DNA-methyltransferases. At high concentrations, this leads to cell death. At low concentrations, decitabine is considered to exert its anticancer effects by inducing DNA hypomethylation. This results in reactivation of epigenetically repressed genes, such as tumour suppressor genes and, potentially, cell differentiation. In a randomized, Phase III trial of decitabine versus best supportive care in patients with MDS, the overall response rate with decitabine was 17%, including 9% complete remissions. Patients at high risk had a statistically significant prolongation of time to acute myelogenous leukemia transformation or death. This experience has been followed by a study of low-dose decitabine using a five-times daily 1-h infusion schedule, with significant efficacy in patients with MDS observed. Ongoing studies are evaluating the activity and safety of the combination of decitabine with several histone deacetylase inhibitors and other indications. This article summarizes the experience in with decitabine in MDS.
Speed-Adaptation Mechanism: Robotic Prostheses Can Actively Regulate Joint Torque

By 2050, an estimated 1.5 million people in the United States will be living with a major lower-limb amputation [1], a condition that causes severe disability, particularly for persons with transfemoral (above-knee) amputations. These individuals expend up to twice the metabolic effort to walk at half the speed [2] of able-bodied persons, and they experience a higher risk of falls and secondary pathological conditions, such as osteoarthritis, back pain, and depression [3].
Generalized contrast functions for blind separation of overdetermined linear mixtures with unknown numbers of sources

In this paper, we address the problem of blind separation of m independent sources from their n linear mixtures in the overdetermined systems (n ges m) with unknown number of sources. After generalizing the definition of classical and nonsymmetrical contrast functions, we exhibit a wide class of generalized contrast functions using some superadditive functional and concave functions. Two practical generalized contrasts based on the support Lebesgue measure (SLM) and the mutual information (MI) criteria are proposed and discussed. Finally, computer simulations illustrate the results and demonstrate all the interest we can find in considering a generalized contrast function
Individual vs. Aggregate Decision Making – Diversification Discount

Section 1: Introduction Many firms have operations in different segments. Such decisions to diversify presume that managers believe that diversification is more valuable for the firm than not being diversified. However, the market does not always value a diversified firm as the managers' or economists' models would imply. In fact, some studies found the suggestive evidence that diversified firms are actually valued at prices lower than non-diversified firms. This is contrary to economic theory and to managers' implicit motivation to diversify. The discount at which diversified firms trade is known as the
Acquiring a Lexicon by Actively Querying the User

We present a semi-automatic approach to lexical acquisition which utilizes experiences from earlier systems by the authors and others. The hybrid system combines the subsystems in the following way: a fully automatic approach (EBL 2 ) is extended with grammatical constraints (SWECG) which lters output hypotheses, thus improving on the accuracy of the automatic paradigm assignments. Candidate sentences are generated using paradigm patterns from a semiautomatic lexical acquistion tool (VEX). These are presented to and judged for grammaticality by the user. This hybrid approach has several advantages compared to using either of the subsystems in isolation. It does not require any linguistic knowledge on the part of the user. Possible extensions to an existing lexicon are automatically selected by the system. Due to the strength of the combined strategy a 100% accuracy guarantee should be quite feasible.
Do Beliefs About Peers Matter for Donation Matching? Experiments in the Field and Laboratory

Charitable giving has been about 2% of US GDP since the turn of the century. A popular fundraising tool is donation matching where every dollar is matched by a third party. But field experiments find that matching does not always increase donations. This may occur because individuals believe that peer donors will exhaust the matching funds. We develop a theory of how beliefs about peers' donations affect one's own likelihood of donation. We test our theory using novel "threshold match" treatments in field and laboratory experiments. These treatments form small groups and offer a flat matching bonus if a threshold number of donations is received. One "threshold match" treatment more than doubles the donation rate in the field relative to no match. To better understand the mechanism behind this huge increase, we use a lab study to replicate the field results and further show that beliefs about peers' donations matter. Our theoretical, lab, and field results combined suggest people are more likely to donate when they believe they are more pivotal to securing matching money. Beliefs about others matter, and they should be taken into account when trying to increase donations.
The aerodynamic effects of wing–wing interaction in flapping insect wings

SUMMARY We employed a dynamically scaled mechanical model of the small fruit fly Drosophila melanogaster (Reynolds number 100–200) to investigate force enhancement due to contralateral wing interactions during stroke reversal (the `clap-and-fling'). The results suggest that lift enhancement during clap-and-fling requires an angular separation between the two wings of no more than 10–12°. Within the limitations of the robotic apparatus, the clap-and-fling augmented total lift production by up to 17%, but depended strongly on stroke kinematics. The time course of the interaction between the wings was quite complex. For example, wing interaction attenuated total force during the initial part of the wing clap, but slightly enhanced force at the end of the clap phase. We measured two temporally transient peaks of both lift and drag enhancement during the fling phase: a prominent peak during the initial phase of the fling motion, which accounts for most of the benefit in lift production, and a smaller peak of force enhancement at the end fling when the wings started to move apart. A detailed digital particle image velocimetry (DPIV) analysis during clap-and-fling showed that the most obvious effect of the bilateral `image' wing on flow occurs during the early phase of the fling, due to a strong fluid influx between the wings as they separate. The DPIV analysis revealed, moreover, that circulation induced by a leading edge vortex (LEV) during the early fling phase was smaller than predicted by inviscid two-dimensional analytical models, whereas circulation of LEV nearly matched the predictions of Weis-Fogh's inviscid model at late fling phase. In addition, the presence of the image wing presumably causes subtle modifications in both the wake capture and viscous forces. Collectively, these effects explain some of the changes in total force and lift production during the fling. Quite surprisingly, the effect of clap-and-fling is not restricted to the dorsal part of the stroke cycle but extends to the beginning of upstroke, suggesting that the presence of the image wing distorts the gross wake structure throughout the stroke cycle.
Mutation of Arabidopsis SMC4 identifies condensin as a corepressor of pericentromeric transposons and conditionally expressed genes

In this study, Wang et al. perform genome-wide analyses that implicate condensin in the suppression of hundreds of loci, acting in both DNA methylation-dependent and methylation-independent pathways. They show that silencing of transposons in the pericentromeric heterochromatin of Arabidopsis thaliana requires SMC4, a core subunit of condensins I and II, acting in conjunction with CG methylation by MET1, CHG methylation by CMT3, the chromatin remodeler DDM1, and histone modifications, including H3K27me1, imparted by ATXR5 and ATXR6.