Miracle-dz/UniFAR-FTUs huggingface dataset:
Differential binding of colors to objects in memory: red and yellow stick better than blue and green

Both evolutionary considerations and recent research suggest that the color red serves as a signal indicating an object’s importance. However, until now, there is no evidence that this signaling function of red is also reflected in human memory. To examine the effect of red on memory, we conducted four experiments in which we presented objects colored in four different colors (red, green, blue, and yellow) and measured later memory for the presence of an object and for the color of an object. Across experiments, we varied the type of objects (words vs. pictures), task complexity (single objects vs. multiple objects in visual scenes), and intentionality of encoding (intentional vs. incidental learning). Memory for the presence of an object was not influenced by color. However, in all four experiments, memory for the color of an object depended on color type and was particularly high for red and yellow-colored objects and particularly low for green-colored objects, indicating that the binding of colors into object memory representations varies as a function of color type. Analyzing the observers’ confidence in their color memories revealed that color not only influenced objective memory performance but also subjective confidence. Subjective confidence judgments differentiated well between correct and incorrect color memories for red-colored objects, but poorly for green-colored objects. Our findings reveal a previously unknown color effect which may be of considerable interest for both basic color research and applied settings like eyewitness testimony in which memory for color features is relevant. Furthermore, our results indicate that feature binding in memory is not a uniform process by which any attended feature is automatically bound into unitary memory representations. Rather, memory binding seems to vary across different subtypes of features, a finding that supports recent research showing that object features are stored in memory rather independently from each other.
AROMA: ambient awareness through olfaction in a messaging application

This work explores the properties of different output modalities as notification mechanisms in the context of messaging. In particular, the olfactory (smell) modality is introduced as a potential alternative to visual and auditory modalities for providing messaging notifications. An experiment was performed to compare these modalities as secondary display mechanisms used to deliver notifications to users working on a cognitively engaging primary task. It was verified that the disruptiveness and effectiveness of notifications varied with the notification modality. The olfactory modality was shown to be less effective in delivering notifications than the other modalities, but produced a less disruptive effect on user engagement in the primary task. Our results serve as a starting point for future research into the use of olfactory notification in messaging systems.
Accounting for the `dark side' of new organizational forms: The case of healthcare professionals

Our study responds to a call for research to integrate institutional, organizational and individual levels of analysis in examining the implications for work and employment relations of new organizational forms. We empirically examine the implementation of network forms of genetics healthcare delivery that cross organizational and professional boundaries. We highlight that less powerful professional groups may find difficulty in enacting boundary-spanning roles associated with new organizational forms. This is due, first, to inconsistency of government policy, which fragments organizations. Second, professional institutions sustain professional hierarchy and power differentials.
Characterization of Structural Domains of Human Osteoclastogenesis Inhibitory Factor*

Osteoclastogenesis inhibitory factor (OCIF) is a heparin-binding secretory glycoprotein that belongs to the tumor necrosis factor receptor (TNFR) family. OCIF is present both as a ∼60-kDa monomer and a disulfide-linked homodimer. We attempted to characterize the seven structural domains of OCIF by determining the capabilities of various OCIF mutants to inhibit osteoclastogenesis, to interact with heparin, and to form dimers. We also examined a potential of domains 5 and 6, death domain homologous regions (DDHs), for inducing cell death by expressing OCIF/Fas fusion proteins. Our results show that: (i) the N-terminal portion of OCIF containing domains 1–4, which have structural similarity to the extracellular domains of the TNFR family proteins, is sufficient to inhibit osteoclastogenesis; (ii) a heparin-binding site is located in domain 7, and affinity for heparin does not correlate with the inhibitory activity; (iii) Cys-400 in domain 7 is the residue responsible for dimer formation; and (iv) the C-terminal portion containing domains 5 and 6, DDHs, has a high potential for mediating a cytotoxic signal when it is expressed in cells as an OCIF/Fas fusion protein in which the transmembrane region of Fas is inserted in front of DDHs.
Warfarin Therapy for Atrial Fibrillation in the Elderly

OBJECTIVE: To evaluate a clinical practice model that addresses special needs for managing anticoagulation in a community-dwelling elderly population with atrial fibrillation and high risk of stroke. METHODS: Medical records of 18 patients (mean age 82 y) followed by the Geriatric Ambulatory Program over 2 years, with a target international normalized ratio (INR) of 2.0–3.0, were reviewed. Risk factors for stroke, number and results of INR tests, suspected reasons for suboptimal response, and adverse events were analyzed. Patients were defined as having cognitive impairment if they had a Folstein Mini-Mental State Exam score ≤26. Functional impairment was defined by ≥2 disabilities in activities of daily living. RESULTS: Eighty-three percent (15/18) had ≥2 additional stroke risk factors. Fifty-one percent (273/541) of INR responses were therapeutic. Female gender (p = 0.015) and cognitive (p = 0.019) and functional impairment (p = 0.001) were associated with supratherapeutic INR response. All patients with cognitive impairment and 85% of those with functional impairment received caregiver support for medication administration. There were 4 minor bleeding events and no thromboembolic events. The mean number of medications was 9.3 in those with bleeding versus 6.8 in those without bleeding (p = 0.052). CONCLUSIONS: Elderly patients with high stroke risk achieved therapeutic INR responses. However, those with significant cognitive or functional impairment require caregiver support and special consideration for anticoagulation management.
'Growing the Size of the Black Woman': Feminist Activism in Havana Hip Hop

This essay focuses on the music of the Black, all-female Cuban hip-hop group Las Krudas as a form of feminist activist art. Analyzing the group's lyrics and its members' self-conscious identification as feminists reveals insight into the role of music as a public forum that makes visible the social, sexual, and economic oppression of African-descended women in Cuban society.
Acidos graxos das series omega 3 e 6 e suas implicacoes na saude humana

KIRIAQUE BARRA FERREIRA BARBOSA1; ANA CAROLINA PINHEIRO VOLP1; ISIS RODRIGUES TOLEDO RENHE2; PAULO CÉSAR STRINGHETA3 1Doutoranda do Programa de Pós Graduação em Ciência e Tecnologia de Alimentos da Universidade Federal de Viçosa; 2Mestranda do Programa de Pós Graduação em Ciência e Tecnologia de Alimentos da Universidade Federal de Viçosa; 3Departamento de Tecnologia de Alimentos da Universidade Federal de Viçosa. Departamento onde o trabalho foi realizado: Departamento de Tecnologia de Alimentos da Universidade Federal de Viçosa Endereço para correspondência: Kiriaque Barra Ferreira Barbosa R. José Euclides Santana, no 230, Santa Clara, Viçosa, MG, CEP 36571.000 Telefone: (31) 3891-3903 / Celular: (31) 8783-1841 E-mail: kiribarra@yahoo.com. br BARBOSA, K. B. F. ; VOLP, A. C. P.; RENHE, I. R. T. ; STRINGHETA, P. C.
Clinical Benefit of Eplerenone in Patients With Mild Symptoms of Systolic Heart Failure Already Receiving Optimal Best Practice Background Drug Therapy: Analysis of the EMPHASIS-HF Study

Background—In EMPHASIS-HF (Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure), eplerenone significantly reduced major cardiovascular events versus placebo in 2737 patients with mild symptoms of heart failure and an ejection fraction of <35%, in addition to recommended therapy. However, it is not known whether such benefits were preserved in patients receiving optimal background drug therapy, that is, high doses of angiotensin-converting enzyme inhibitor (ACEi, or angiotensin receptor blocker), &bgr;-blocker, or both drug classes. Methods and Results—We further analyzed EMPHASIS-HF according to the use and dose of these background drug classes. Patients receiving ≥50% of target dose were considered to be receiving high doses; patients on <50% or no drug comprised the low-dose group. The primary end point of the study (cardiovascular death/heart failure hospitalization), as well as all-cause mortality, was evaluated in this way. The beneficial clinical effects of eplerenone (as observed in the main study) were preserved for the EMPHASIS-HF primary end point in patients receiving higher doses of ACEi or angiotensin receptor blocker, &bgr;-blocker, or both (hazard ratio for eplerenone versus placebo, ACEi/angiotensin receptor blocker: high dose, 0.67; low dose, 0.65; &bgr;-blockers: high dose, 0.55; low dose, 0.72; both ACEi/angiotensin receptor blocker and &bgr;-blocker: high dose, 0.59; low dose, 0.68; P value for interaction 0.80, 0.15, and 0.53, respectively), as well as for all-cause mortality. There were no major safety issues, except a borderline increased risk of hypotension with eplerenone in those on high-dose ACEi or ACEi/&bgr;-blocker. Conclusions—Eplerenone provides substantial benefit on major events (with an acceptable safety profile) in patients with mild symptoms of systolic heart failure, even in those already receiving high doses of standard background therapies. Clinical Trial Registration—URL: http://www.clinicaltrials. gov. Unique identifier: NCT00232180.
[The jimpy mouse].

Ultrastructural study of the Jimpy mice shows lack of myelin in the central nervous system: low density of glial cells, defect of maturation of oligodendrocytes and deficiency in axonal growth. The lack of myelin is more proeminent in late myelinating structures: corpus callosum and corticospinal fasciculus. Failure in myelin is rather the consequence of an early interruption of myelination as that of demyelination (a destruction of the sheats).
Evidence for Pre- to Postsynaptic Mismatch of the Cardiac Sympathetic Nervous System in Ischemic Congestive Heart Failure

Pre- and postsynaptic cardiac sympathetic function is altered in ischemic congestive heart failure (CHF). Whether there is a presynaptic-to-postsynaptic mismatch or whether mismatch is related to adverse cardiac events is unknown. Methods: In 13 patients with ischemic CHF and 25 aged-matched healthy volunteers, presynaptic function was measured by PET of 11C-meta-hydroxyephedrine (11C-mHED), a norepinephrine (NE) analog. Postsynaptic function, β-adrenergic receptor (BAR) density (B′max), was measured by imaging 11C-CGP12177. Myocardial blood flow (MBF) was measured by imaging 15O-water. Each heart was analyzed both globally and regionally, excluding infarcted regions, and a mismatch score, defined as the ratio of B′max to NE uptake (PSnt), was used to indicate mismatch of post- and presynaptic function. Results: Global and regional MBF was not different between CHF and healthy subjects. The global measure of PSnt was lower in CHF (0.32 ± 0.34) than that in healthy subjects (0.81 ± 0.33, P < 0.0001) and in all 12 regions. Global B′max tended to be lower in CHF than that in healthy subjects (10.0 ± 6.4 pmol/mL vs. 13.4 ± 4.2, P = 0.056) and in all 12 regions. The global mismatch score (B′max:PSnt) in CHF patients was significantly greater than that in healthy subjects (50.3 ± 50.7 vs. 19.3 ± 9.7, P = 0.005) and also greater in 11 of 12 regions. After 1.5 y of follow-up, 4 individuals had an adverse outcome (CHF death, new or recurrent sudden death, or progressive CHF leading to transplantation). Three of the 4 had mismatch scores > 3 times that of the healthy subjects or the CHF patients without an adverse outcome. Conclusion: Mismatch between pre- and postsynaptic left ventricular sympathetic function is present in patients with severe CHF and may be more marked in those with adverse outcomes.
Biomechanical comparison of two ostectomy configurations for partial mandibulectomy

Summary Objective: To determine the stiffness and load to failure of two different ostectomy configurations using canine mandibles. Study design: Cadaveric biomechanical assessment. Animals: Paired mandibles (n = 30). Methods: Standardized partial ostectomies were created on the alveolar surface of 30 mandibles. Samples were randomly assigned to right-angled (n = 15) or crescentic ostectomy (n = 15). Excision spanned the mesial aspect of the fourth premolar tooth to the distal aspect of first molar tooth. Mandibles were loaded to failure in three-point ben-ding. The stiffness, displacement at maximum load, and load to failure were measured. Results: There was no significant difference in stiffness (p = 0.59), displacement at maximum load (p = 0.16) and load to failure (p = 0.76) between right-angled or crescentic ostectomy. Right-angled and crescentic ostectomy failed mostly by fracture through an empty alveolus (11/15 and 13/15, respectively). Clinical relevance: No significant differences in load to failure or stiffness between ostectomy techniques were observed. Crescentic ostectomy did not improve the acute load to failure for partial mandibulectomy. The empty alveolus served as a focal stress concentration point eliminating the potential mechanical advantage of a crescentic ostectomy.
Older Adult Migration to the Sunbelt

Previous research has documented that, in the aggregate, older adult migrants to the Sunbelt tend to have higher average incomes than age-peer native residents. Using individual-level data on older Florida residents, the present study examines the extent to which this difference is due to compositional differences in factors that correlate with income, rather than to differences in income, per se. To compare specifically the income characteristics of the in-migrant and native portions of a place's older population, it is necessary to standardize the two groups on other relevant characteristics. The analyses suggest that the income advantage of migrants occurs principally among those older adults who migrate in conjunction with the retirement decision, and that it results mainly from a self-selection process.
A new hybrid passive/active noise absorption system

A new hybrid passive–active system is developed for sound absorption over a wide frequency range. The system is comprised of a layer of absorbing material positioned at a distance from an active wall, leaving an air space. The motion of the active wall is based on a new control approach which consists of the minimization of the reflected wave within the airspace which modifies the layer’s back surface impedance so as to match the characteristic impedance of air. This technique is referred here as inducing an impedance-matching condition. Both numerical and experimental results of such a system are presented for normally incident planar waves. The hybrid passive–active system results in a high absorption coefficient of 0.8–1.0 over the frequency range 100–2000 Hz and is insensitive to system parameters such as air space depth and absorbing layer thickness.
Constraints on dark matter and the shape of the Milky Way dark halo from the 511-keV line

About one year ago, it was speculated that decaying or annihilating light dark matter (LDM) particles could explain the flux and extension of the 511-keV line emission in the Galactic Centre. Here, we present a thorough comparison between theoretical expectations of the Galactic positron distribution within the LDM scenario and observational data from INTEGRAL/SPI. Unlike previous analyses, there is now enough statistical evidence to put tight constraints on the shape of the dark matter (DM) halo of our Galaxy, if the Galactic positrons originate from DM. For annihilating candidates, the best fit to the observed 511-keV emission is provided by a radial density profile with inner logarithmic slope γ = 1.03 ± 0.04. In contrast, decaying DM requires a much steeper density profile, γ> 1.5, rather disfavoured by both observations and numerical simulations. Within the annihilating LDM scenario, a velocity-independent cross-section would be consistent with the observational data while a cross-section purely proportional to v 2 can be rejected at a high confidence level. Assuming the most simplistic model where the Galactic positrons are produced as primaries, we show that the LDM candidate should be a scalar rather than a spin-1/2 particle and obtain a very stringent constraint on the value of the positron production cross-section to explain the 511-keV emission. One consequence is that the value of the fine structure constant α should differ from that recommended in the CODATA (Committee on Data for Science and Technology). This is a very strong test for the LDM scenario and an additional motivation in favour of experiments measuring α directly. Our results finally indicate that an accurate measurement of the shape of the dark halo profile could have a tremendous impact on the determination of the origin of the 511-keV line and vice versa.
PENGARUH PENERIMAAN PENGGUNA DAN EKONOMI TERHADAP KEEFEKTIFAN PEMILIHAN PROYEK SISTEM INFORMASI DENGAN PENDEKATAN SEM

Pemilihan proyek sistem informasi sangat sulit dilaksanakan karena banyak faktor yang mempengaruhinya. Banyak proyek sistem informasi yang gagal karena tidak memperhatikan kepada penerimaan pengguna. Selain itu faktor lain yang mempengaruhi adalah terbatasnya dana . Tujuan dari makalah ini adalah meneliti faktor ekonomi dan penerimaan pengguna dalam pemilihan proyek sistem informasi. Untuk analisis data digunakan metode pendekatan Model Persamaan Struktural (SEM). Hasil dari penelitian ini adalah ekonomi dan penerimaan pengguna berpengaruh terhadap pemilihan proyek sistem informasi. Selain itu penerimaan pengguna sebagai mediator dari ekonomi ke pemilihan proyek sistem informasi. Penerimaan pengguna diukur dengan kebergunaan dan kemudahgunaan, dengan menggabungkan keduanya maka lebih valid dan handal. Sehingga hasil akhir dari pengerjaan akan lebih efektif, sederhana dan lebih mudah
Gating and Single Channel Properties of Gap Junction Channels in Hepatopancreatic Cells of Procambarus clarkii.

ancy, we have compared subsets of our data with regard to location of injection (anterior vs. posterior gland regions in Table IA), large versus small glands (Table IB), and glands injected at different times of day (early vs. late in Table IB). These restricted data sets revealed significantly weaker coupling in smaller glands than in larger glands, but no evidence for an effect of per genotype. Thus, while other variables affect coupling in this tissue, we conclude that the per gene itself does not detectably influence the extent of intercellular coupling in larval salivary glands. We thank Daniel Goodenough, in whose laboratory some of these experiments were performed, for hospitality and guidance, and Marc Chanson and Matthew Clausen for help with scoring injections. This work was supported by NIH grants GM-33205 (to J.C.H. and M.R.), and NS-16524 (to D.C.S.), and NSFgrant 9057703 (to K.K.S.). I,
Lessons Learned from Implementing WS-Coordination and WS-AtomicTransaction

This paper presents the design and implementation of a transaction service that complies with the WS-Coordination and WS-AtomicTransaction standards. Such service builds upon XActor, a distributed transaction manager that supports an open-ended set of transports, and enhances it with full support for atomic transactions over Web services. The paper summarizes the main lessons we learned from implementing those standards. It also identifies weaknesses in the WS-AtomicTransaction specification and presents advice for implementors of any systems based upon WS-Coordination.
Balancing Causes and Consequences: The Magnitude-Matching Principle in Explanations for Complex Social Events

We assessed whether people use a magnitude-matching principle in determining causes for complex social events. We hypothesized that individuals tend to favor causal explanations that match the event in terms of size and scope. In Experiment 1, the magnitude of the consequences of events was manipulated, and participants were presented with two potential causes of modest magnitude and two potential causes of high magnitude. Analyses revealed a relative magnitude-matching effect such that participants were more likely to select high magnitude causes for large magnitude events than modest magnitude events and more likely to select modest magnitude causes for modest magnitude events than large magnitude events. Experiment 2 replicated the magnitude-matching effect with a different event and set of causes, and demonstrated that this effect could be reversed by undermining participants' beliefs in the magnitude-matching principle.
Low temperature slowing and cold-block of fast axoplasmic transport in mammalian nerves in vitro.

1) Fast axoplasmic transport in mammalian nerve in vitro was studied using an isotope labeling technique. The rate of outflow in cat sciatic nerve fibers of 410 mm/day in vitro was reduced at temperatures below 38 degrees C with a Q10 of 2.0 in the range 38-18 degrees C and a Q10 of 2.3 at 38-13 degrees C. 2) At a temperature of 11 degrees C a partial failure of transport occurred. At temperatures below 11 degrees C a complete block of fast axoplasmic transport occurred, a phenomenon termed "cold-block. " No transport at all was seen over the temperature range of 10-0 degrees C for times lasting up to 48 hr. 3) Transport was resumed after a period of cold-block lasting up to 22 hr when the nerves were brought back to a temperature of 38 degrees C. Some deleterious effects due to cold-block were seen in the recovery phase as indicated by a reduction in crest amplitude, change in its form, and slowed rate. 4) The approximately P level (combined ATP and creatine phosphate) remained near control level in nerves kept at low or cold-block temperatures for times as long as 64 hr. The reduction in fast axoplasmic transport rate seen at low temperatures for times up to 22 hr was therefore considered due to a decrease in the utilization of ATP, a concept in accord with the "transport filament" model proposed to account for fast axoplasmic transport. 5) The sloping of the front of the crest over the temperature range of 18-13 degrees C suggests an additional factor at the lower temperatures. A disassembly of microtubules is discussed as a possible explanation of the cold-block phenomenon.