Miracle-dz/UniFAR-FTUs huggingface dataset:
Determinants of Inflation and Price Level Differentials Across the Euro Area Countries

This paper analyses the determinants of inflation differentials and price levels across the euro area countries. Dynamic panel estimations for the period 1999-2006 show that inflation differentials are primarily determined by cyclical positions and inflation persistence. The persistence in inflation differentials appears to be partly explained by administered prices and to some extent by product market regulations. In a cointegrating framework we find that the price level of each euro area country is governed by the levels of GDP per capita. JEL Classification: E32, E52, E43, F2
The Wilms' tumor gene Wt1 is required for normal development of the retina

The Wilms' tumor gene Wt1 is known for its important functions during genitourinary and mesothelial formation. Here we show that Wt1 is necessary for neuronal development in the vertebrate retina. Mouse embryos with targeted disruption of Wt1 exhibit remarkably thinner retinas than age‐matched wild‐type animals. A large fraction of retinal ganglion cells is lost by apoptosis, and the growth of optic nerve fibers is severely disturbed. Strikingly, expression of the class IV POU‐domain transcription factor Pou4f2 (formerly Brn‐3b), which is critical for the survival of most retinal ganglion cells, is lost in Wt1−/− retinas. Forced expression of Wt1 in cultured cells causes an up‐regulation of Pou4f2 mRNA. Moreover, the Wt1(−KTS) splice variant can activate a reporter construct carrying 5′‐regulatory sequences of the human POU4F2. The lack of Pou4f2 and the ocular defects in Wt1−/− embryos are rescued by transgenic expression of a 280 kb yeast artificial chromosome carrying the human WT1 gene. Taken together, our findings demonstrate a continuous requirement for Wt1 in normal retina formation with a critical role in Pou4f2‐dependent ganglion cell differentiation.
Comparative Loss-of-Function Screens Reveal ABCE1 as an Essential Cellular Host Factor for Efficient Translation of Paramyxoviridae and Pneumoviridae

The Paramyxoviridae and Pneumoviridae families include important human and animal pathogens. To identify common host factors, we performed genome-scale siRNA screens with wild-type-derived measles, mumps, and respiratory syncytial viruses in the same cell line. A comparative bioinformatics analysis yielded different members of the coatomer complex I, translation factors ABCE1 and eIF3A, and several RNA binding proteins as cellular proteins with proviral activity for all three viruses. A more detailed characterization of ABCE1 revealed its essential role for viral protein synthesis. Taken together, these data sets provide new insight into the interactions between paramyxoviruses and pneumoviruses and host cell proteins and constitute a starting point for the development of broadly effective antivirals. ABSTRACT Paramyxoviruses and pneumoviruses have similar life cycles and share the respiratory tract as a point of entry. In comparative genome-scale siRNA screens with wild-type-derived measles, mumps, and respiratory syncytial viruses in A549 cells, a human lung adenocarcinoma cell line, we identified vesicular transport, RNA processing pathways, and translation as the top pathways required by all three viruses. As the top hit in the translation pathway, ABCE1, a member of the ATP-binding cassette transporters, was chosen for further study. We found that ABCE1 supports replication of all three viruses, confirming its importance for viruses of both families. More detailed characterization revealed that ABCE1 is specifically required for efficient viral but not general cellular protein synthesis, indicating that paramyxoviral and pneumoviral mRNAs exploit specific translation mechanisms. In addition to providing a novel overview of cellular proteins and pathways that impact these important pathogens, this study highlights the role of ABCE1 as a host factor required for efficient paramyxovirus and pneumovirus translation. IMPORTANCE The Paramyxoviridae and Pneumoviridae families include important human and animal pathogens. To identify common host factors, we performed genome-scale siRNA screens with wild-type-derived measles, mumps, and respiratory syncytial viruses in the same cell line. A comparative bioinformatics analysis yielded different members of the coatomer complex I, translation factors ABCE1 and eIF3A, and several RNA binding proteins as cellular proteins with proviral activity for all three viruses. A more detailed characterization of ABCE1 revealed its essential role for viral protein synthesis. Taken together, these data sets provide new insight into the interactions between paramyxoviruses and pneumoviruses and host cell proteins and constitute a starting point for the development of broadly effective antivirals.
Global Crisis: Global Opportunity? Trade Unions, Migration and Social Transformation

Preface As we enter uncharted waters in terms of the outcome of the global crisis of capitalism which has only got more serious since 2007 we might well ask if it represents a new global opportunity for labour and the subaltern classes more generally. In particular I seek to address the complex and sometimes conflictual relations between trade unions, migration and the ongoing processes of social transformation. In the first instance I pose the Challenges which migration represents for trade unions in the context of globalisation. More broadly I examine the challenges for progressive social theory posed by the current global crisis. I then move on to the Mutations of the global system on the basis of Gramsci’s dictum that ‘the old has died but the new has not yet been born’. This is the necessary framework for the subsequent analysis of Workers in the context of the processes of globalisation and precarisation. My hypothesis is that we are now moving beyond the categories of North and South in terms of the mutations of capitalism and their impact on the workers of the world (see Munck 2011). Finally, I turn to the sometimes under-rated Complexity of the way workers are responding to the mutations of capitalism and thus posing a very real challenge to the stable reproduction of capitalist rule. I sketch out the limitations of a rights-based labour response to exploitation and the opportunities arising for a new multi-scalar global social unionism.
Revascularisation in older adult patients with non-ST-segment elevation acute coronary syndrome: effect and impact on 6-month mortality

Although revascularisation in non-ST-segment elevation acute coronary syndrome (NSTEACS) is associated with better outcomes, its impact in older adult patients is unclear. This is a retrospective analyses of three national NSTEACS registries conducted during the past decade in Spain. Patients aged 75 years and older were included: DESCARTES (DES; year 2002; n=534), MASCARA (MAS; 2005; n=1736) and DIOCLES (DIO; 2012; n=593). The adjusted association between revascularisation and total (inhospital and 6-month) mortality was estimated by two-stage meta-analysis (pooled effect across the three registries with inverse-variability weights) and one-stage meta-analysis (multilevel model with random effects across studies). The impact of revascularisation was assessed comparing the observed and the expected mortality based on a logistic regression model in the pooled database. Although revascularisation was associated with a lower risk of mortality in meta-analyses (two-stage: odds ratio 0.44, 95% confidence interval 0.29–0.67; one-stage: odds ratio 0.54, 95% confidence interval 0.36–0.81) and the revascularisation rate increased steadily from 2002 (DES 14.2%) to 2012 (DIO 43.7%), its impact was not patent across registries, probably because this increase was concentrated in low and medium-risk GRACE strata (tertile 1, 2 and 3: MAS 59%, 20% and 6%; DIO 64%, 39% and 19%, respectively). In conclusion, a consistent increase of revascularisation in NSTEACS in older adults was not followed by a decrease in mortality at 6 months, probably because the impact of this strategy is limited to the higher risk population, the stratum with the lowest revascularisation rate in real life.
Novel patient-specific navigational template for total knee arthroplasty

Current techniques for total knee arthroplasty have certain drawbacks, including violation of the intramedullary canals and limited accuracy. The aim of this research was to develop and validate the accuracy of a new computer-assisted preoperative planning concept for the creation of patient-specific navigational templates to replace conventional instruments. Volumetric computerized tomography (CT) scanning was performed on 30 cadaveric knees, and a three-dimensional reconstruction model of each knee was generated from the scan data. Using a reverse-engineering technique, optimal lower-limb alignment and rotational alignment were determined. A navigational template was also designed with a surface that matched the distal femur and proximal tibia. This template, with its corresponding femur and tibia, was manufactured using a rapid-prototyping technique and tested for violations. The navigational template was then used intraoperatively to assist with an arthroplasty in each of the 30 cadaveric knees. Following surgery, the positions of the prostheses were evaluated with X-rays and CT scans. The method showed a high degree of accuracy and reproducibility. In all cases, placing the template manually on the lamina of the femur and tibia was relatively easy. Twenty-eight prostheses were considered to be positioned entirely accurately, whereas two prostheses were considered to have a 1–2° malpositioning. This study thus introduces a novel navigational template for total knee arthroplasty. Preliminary cadaveric trials have demonstrated that this design can improve the accuracy of osteotomy in the surgical procedure.
Managing the Emergency Response.

The first few hours following any large-scale disaster present a complex array of organizational demands that constitute a unique managerial problem. As the disaster agent changes from tornado or hurricane to toxic chemical spill or terrorist threat so, too, does the set of responding organizations and the specific tasks they confront. Despite obvious differences in the demand structures generated by such large-scale emergencies, research studies completed during the last two decades have validated the utility of a generalized approach. Initially referred to as a dual-use orientation, the concept of Comprehensive Emergency Management (CEM)' has emerged as a partial response to a long-recognized need -improved hazard and disaster management, including emergency responses.2 "Fiscal year 1984 marks the initial implementation of the Integrated Emergency Management System (IEMS) at all levels of government nationwide. "3 CEM is the long-term objective, IEMS is the current implementation strategy.4 The thesis of this article is that efforts to promote IEMS, or any other disaster management tool, require explicit recognition of fundamental structural qualities that characterize emergency responses within American society. The presentation is divided into four sections: (1) the American scene; (2) who actually responds? ; (3) strategies for enhancing intergovernmental coordination; and (4) implications for managing emergency responses.
An improved layout verification algorithm (LAVA)

The correctness of a VLSI circuit layout can be verified by comparing the netlist extracted from the layout with the specification netlist. Ebeling and Zajicek (1983) showed that this problem can be solved by utilizing known techniques for solving the classical graph isomorphism problem. The authors present an improved algorithm for solving the graph isomorphism problem associated with layout verification. This algorithm takes advantage of the bipartite nature of the graphs associated with the layout verification problem. The sum of the improvements in this algorithm tends to relieve the memory-intensive problems and accelerate the process. <<ETX>>
Modulation of PECAM-1 (CD31) Expression in Human Endothelial Cells: Effect of IFNγ and IL-10

Intercellular contacts formed between endothelial cells (EC) permit the formation of a confluent monolayer and play a major role in the recruitment and the migration of leukocytes in the inflammatory response. It is currently accepted that cytokines are responsible for the signals involved in the induction of such endothelial alterations. The platelet EC adhesion molecule (PECAM-1), a specific component of EC junctions, is one of many molecules which participate in the regulation of EC interaction with blood components. Given that the regulatory mechanisms which affect the expression of this adhesion molecule are only partially understood, the aim of the present study was to compare the effects of two antagonistic inflammatory cytokines, interferon (IFN)-γ and interleukin (IL)-10, on the expression of PECAM-1. Human umbilical vein EC grown to subconfluence were stimulated with IL-10 (10 ng/ml) and/or IFNγ (100 U/ml) for 24 h. PECAM-1 expression was determined by FACScan and immunofluorescence. Morphological analysis of the cell cultures was performed by optical and scanning electron microscopy. In the presence of IL-10, no changes in cell growth and morphology or in the intensity of PECAM-1 expression were observed. However, when the cultures were treated with IFNγ, the EC acquired a fibroblast-like appearance, growth was disorganized and PECAM-1 disappeared from cell junctions. The mean intensity expression and the percentage of EC expression of this antigen were analyzed by flow cytometry and significantly decreased after culture in the presence of IFNγ. The simultaneous addition of IFNγ and IL-10 to the EC cultures induced modifications similar to those observed in the presence of IFNγ alone. Regulation of the expression of PECAM-1 with the subsequent functional implications seems to be dependent upon the IFNγ signal and it is unaffected by IL-10. The different effects shown by IL-10 and IFNγ on the expression of PECAM-1 in EC could reflect opposite regulatory actions of the inflammatory response induced by these cytokines.
Heat stress reveals high molecular mass proteasomes in Arabidopsis thaliana suspension cells cultures

Because of their sessile nature, plants have evolved complex and robust mechanisms to respond to adverse environments. Stress conditions trigger an increase in protein turnover and degradation. Proteasomes are essential to the cell for removing, in a highly regulated manner, partially denatured or oxidized proteins thus minimizing their cytotoxicity. We observed that suspension cells of Arabidopsis thaliana treated with high temperature (37 °C) directed the assembly of high molecular mass proteasomes. The removal of a 75% of the original ubiquitin conjugates and the maintenance of protein carbonyls at basal levels correlated with a specific proteasome profiles. The profiles obtained by the separation of different proteasomes populations by Blue-Native Polyacrylamide Gel Electrophoresis and western blot analysis suggest that synthesis, assembly, and heavy ubiquitination of 20S (CP) subunits are promoted by heat stress.
Ontological Support for the Cultural Contextualisation of Intelligent Learning Environments for Adaptive Education

Within ITS research, most systems rely on data in order to train models for decision making and for customising system behaviour. The inherent bias has been traditionally in favour of developed nations. This paper examines the issues involved in contextualising interactive intelligent educational systems using a semantic approach that leverages the meaning of data rather than common patterns within data. It presents a trio of ontologies for relating conceptual knowledge to sociolinguistic terms in the context of a student’s cultural influences and background. The paper argues that if an ITS can model students culturally, model their languages, and model their cultural concepts, then it would be possible for an ITS to start communicating with students socially and conceptually in a culturally appropriate way. The paper explains the rationale behind the need for ontological concepts when adapting aspects of instruction, how they relate to cultural lexical terms, and examples of when these terms may be suitable for use in educational content and instructional events.
Nonlinear Semi-Analytical Model for Simulation of Few-Mode Fiber Transmission

In this letter, a nonlinear semi-analytical model (NSAM) for simulation of few-mode fiber transmission is proposed. The NSAM considers the mode mixing arising from the Kerr effect and waveguide imperfections. An analytical explanation of the model is presented, as well as simulation results for the transmission over a two mode fiber (TMF) of 112 Gb/s using coherently detected polarization multiplexed quadrature phase-shift-keying modulation. The simulations show that by transmitting over only one of the two modes on TMFs, long-haul transmission can be realized without increase of receiver complexity. For a 6000-km transmission link, a small modal dispersion penalty is observed in the linear domain, while a significant increase of the nonlinear threshold is observed due to the large core of TMF.
Impact of a ban on the open display of tobacco products in retail outlets on never smoking youth in the UK: findings from a repeat cross-sectional survey before, during and after implementation

Background In the UK, a ban on the open display of tobacco products at the point of sale (POS) was phased in between 2012 and 2015. We explored any impact of the ban on youth before, during and after implementation. Methods A repeat cross-sectional in-home survey with young people aged 11–16 years old in the UK was conducted preban (2011, n=1373), mid-ban (2014, n=1205) and postban (2016, n=1213). The analysis focuses on the never-smokers in the sample (n=2953 in total). Preban, we quantified the associations of noticing cigarettes displayed at POS and cigarette brand awareness with smoking susceptibility. We measured any change in noticing cigarettes displayed at POS, cigarette brand awareness and smoking susceptibility between preban, mid-ban and postban. Postban, we assessed support for a display ban, perceived appeal of cigarettes and perceived acceptability of smoking as a result of closed displays. Results Preban, noticing cigarettes displayed at POS (adjusted OR [AOR]=1.97, 95% CI 1.30 to 2.98) and higher brand awareness (AOR=1.15, 95% CI 1.03 to 1.29) were positively associated with smoking susceptibility. The mean number of brands recalled declined from 0.97 preban to 0.69 postban (p<0.001). Smoking susceptibility decreased from 28% preban to 23% mid-ban and 18% postban (p for trend <0.001). Postban, 90% of never-smokers supported the display ban and indicated that it made cigarettes seem unappealing (77%) and made smoking seem unacceptable (87%). Conclusions Both partial and full implementation of a display ban were followed by a reduction in smoking susceptibility among adolescents, which may be driven by decreases in brand awareness.
Financing the resilient city

This paper presents a strategy for scaling climate change adaptation within urban areas. The strategy specifically focuses on the requirements for mobilizing large amounts of capital for adaptation and other urban risk reduction above and beyond the amounts that will likely be mobilized through new international adaptation funds. The paper, based on a report published by ICLEI–Local Governments for Sustainability,(1) proposes a re-framing of the urban adaptation and disaster reduction challenge. The approach shifts the adaptation focus from risk reduction as a primary end in itself to a broader development focus on financing the performance of urban assets, areas and/or systems. This emphasis is elaborated through the concept of “resilience”, an urban design and investment metric that measures the ability of urban areas and their individual assets to perform for users and their investors under a wide range of conditions. The paper argues that such a performance-oriented approach provides a business logic that can attract conventional, private investment flows to climate and disaster risk reduction measures and thereby “mainstream” them.
Accumulation and subcellular distribution of heavy metal in Paulownia fortunei cultivated in lead-zinc slag amended with peat

Abstract The contamination of toxic heavy metals was a major issue of concern in the last century. A fast-growing metal-accumulating woody plant is a promising approach for the remediation of toxic heavy metal. In this study, the transportation of heavy metals (Pb, Zn, Cu, and Cd) in Paulownia fortunei cultivated in lead-zinc slag amended with different mass ratios of peat (CK: 0; T1: 10%; T2: 20%; T3: 30%) was investigated, as well as the subcellular distribution of Pb, Zn, Cu, and Cd in Paulownia fortunei. The results showed that the accumulation content of Pb, Zn, Cu, and Cd in Paulownia fortunei were increased with peat amendment, which was in the range of 4.216 ∼ 6.853, 20.905 ∼ 23.017, 1.898 ∼ 2.572, and 0.530 ∼ 0.616 mg/pot, respectivly. The experimental group with 30% dose of peat showed the best performance on the accumulation content of Pb, Zn, Cu, and Cd, with increase rates (compared to control) of 4.088, 10.573, 1.360, and 0.294 mg/pot, respectively. The bioconcentration, translocation and transfer quantity factor of Pb, Zn, Cu, and Cd were less than 1. Fixation of cell wall and compartmentalization of vacuolar appeared to play an important role in reducing the toxicity of Pb, Zn, Cu, and Cd.
Smooth and clumpy dust distributions in AGN: a direct comparison of two commonly explored infrared emission models

The geometry of dust distribution within the inner regions of active galactic nuclei (AGN) is still a debated issue and relates directly to the AGN unified scheme. Traditionally, models discussed in the literature assume one of the two distinct dust distributions in what is believed to be a toroidal region around the supermassive black holes: a continuous distribution, customarily referred to as smooth, and a concentration of dust in clumps or clouds, referred to as clumpy. In this paper we perform a thorough comparison between two of the most popular models in the literature, namely the smooth models by Fritz et al. and the clumpy models by Nenkova et al., in their common parameter space. Particular attention is paid to the silicate features at similar to 9.7 and similar to 18? mu m, the width of the infrared bump, the near-infrared index and the luminosity at 12.3? mu m, all previously reported as possible diagnostic tools to distinguish between the two dust distributions. We find that, due to different dust chemical compositions used in the two models, the behaviour of the silicate features at 9.7 and 18? mu m is quite distinct between the two models. The width of the infrared bump and the peak of the infrared emission can take comparable values; their distributions do, however, vary. The near-infrared index is also quite different, due partly to the primary sources adopted by the two models. Models with matched parameters do not produce similar spectral energy distributions (SEDs) and virtually no random parameter combinations can result in seemingly identical SEDs.