Miracle-dz/UniFAR-FTUs huggingface dataset:
Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant

Susceptibility to a clinically significant drug hypersensitivity syndrome associated with abacavir use seems to have a strong genetic component. We have previously shown that the presence of HLA-B*5701 strongly predicts abacavir hypersensitivity and have identified a potential susceptibility locus within a 300-kb region between the MEGT1 and C4A6 loci in the central MHC. We now report the results of fine recombinant genetic mapping in an expanded patient population of 248 consecutive, fully ascertained, abacavir-exposed individuals in the Western Australian HIV Cohort Study, in which 18 cases of definite abacavir hypersensitivity (7.3%) and 230 tolerant controls were identified. Haplotype mapping within patients with allelic markers of the 57.1 ancestral haplotype suggests a susceptibility locus within the 14-kb Hsp70 gene cluster. HLA-B*5701 was present in 94.4% of hypersensitive cases compared with 1.7% of controls (odds ratio, 960; P < 0.00001). A haplotypic nonsynonymous polymorphism of Hsp70-Hom (HspA1L, resulting from the substitution of residue M493T in the peptide-binding subunit) was found in combination with HLA-B*5701 in 94.4% of hypersensitive cases and 0.4% of controls (odds ratio, 3,893; P < 0.00001). Individuals with abacavir hypersensitivity demonstrated increased monocyte tumor necrosis factor expression in response to ex vivo abacavir stimulation, which was abrogated with CD8+ T cell depletion. These data indicate that the concurrence of HLA-B*5701 and Hsp70-Hom M493T alleles is necessary for the development of abacavir hypersensitivity, which is likely to be mediated by an HLA-B*5701-restricted immune response to abacavir.
A transformer-based inverted complementary cross-coupled VCO with a 193.3dBc/Hz FoM and 13kHz 1/f3 noise corner

This paper presents a transformer-based inverted complementary cross-coupled voltage-controlled oscillator (VCO) topology. Without compromising the start-up condition, it isolates the source nodes for the cross-coupled devices, suppresses the flicker noise up-conversion, and thus results in a superior phase noise performance. A prototype is implemented in a standard 130nm bulk CMOS process with a core area of 0.34mm2. At 1.86GHz, the measured FoM is 190.3/192.2/193.3dBc/Hz at 10k/100k/1MHz offsets with a 1/f3 phase noise corner of only 13kHz. The VCO consumes 1.1mA from a 1.5V supply. High FoM and low 1/f3 phase noise corners are consistently achieved over 20.8% frequency tuning range (1.68-2.07GHz).
GAGA Principle and Singularity Confinement Property on the Integrable Algebraic Finite Difference Equation

Integrable algebraic finite difference equations are treated from algebraic geometrically. Relation between Singularity Confinement properties of integrable finite difference equations and GAGA principle are considered. We found singularity confinement property of integrable algebraic finite difference equation is natural property from GAGA principle. Key-Words: Finite difference equation, Integrability, Singularity confinement, GAGA principle
Translating Grand Challenges From Concept to Community: The “Communities in Action” Experience

This article provides an example of how one social work school created a community partnership to translate grand challenges from concept to concrete local projects to meet Grand Challenges for Social Work goals. The Grand Challenge to Ensure Healthy Development for All Youth proposes that we have made sufficient scientific advances to—within a decade—reduce the incidence and prevalence of behavioral health problems among children, adolescents, and young adults by 20%, and to reduce the incidence of racial and socioeconomic disparities in behavioral health problems by 20%. In 2014, faculty and students from the University of Washington School of Social Work began working with a broad coalition of community-based agencies, governmental partners, and funding agencies to tackle this grand challenge at the community level. The coalition adopted Communities That Care, a tested model for developing prevention infrastructure in communities by building the capacity of community coalitions to assess and prioritize local need, match need to evidence-based prevention programs, and support quality implementation with sufficient reach to change behavioral health problems at the community level. The collaboration chose the name Communities in Action for this effort. This article illustrates how Communities in Action exemplifies grand challenges implementation and highlights lessons learned that can be applied to other grand challenges efforts.
Renormalization of the Drude conductivity by the electron-phonon interaction.

It is commonly believed that the Drude conductivity is not renormalized by many-body interactions. To the contrary, we show that for impure metals the Drude conductivity is decreased by a temperature-dependent factor proportional to the electron-phonon coupling {lambda}. We demonstrate this effect by both the linear response and the quantum transport approaches. This effect, while comparable to the bare Drude conductivity, will be masked by the large temperature dependence of electron-phonon scattering. We expect such many-body corrections to other transport coefficients. {copyright} {ital 1996 The American Physical Society. }
Multi-Antenna Channels Capacity Estimation Made Easy Towards the non-Rayleigh Channels Case

We attempt to discover closed form expressions to numerically evaluate the capacity of multi-antenna wireless channels. We start from known results for the Gaussian (Rayleigh) channel where the numerical evaluation of the capacity can be simplified by recent advances of random matrices theory and involves the probability distribution of a Wishart matrix. Our goal is to explore different than Rayleigh channels which as a result lead to non-Wishart capacity formulas. Tools based on zonal polynomials and their limitations will be explored.
Actions of GLq (2,C) on C(1,3) and its four dimensional representations

A complete classification is given of all inner actions on the Clifford algebra C(l,3) defined by representations of the quantum group GLq (2,C)qm ≠1, which are not reduced to representations of two commuting “q-spinors”. As a consequence of this classification it is shown that the space of invariants of every GLq (2,C)-action of this type, which is not an action of SLq (2,C), is generatedby 1 and the value of the quantum determinant for the given representation.
An Innovative Approach for Regular Expression Matching Based on NoC Architecture

An new regular expression (regex) matching method based on Network-on-Chip(NoC) architecture is proposed in this paper. The idea is to combine a new kind of regex matching engine implemented in hardware with NoC architecture to get a high matching rate. The Regex matching was performed by partitioning the regex into several parts to make the finite state machine (FSM) simpler. Each part of regex can be matched by an engine cell core, and each core communicates with other cores by routers on a NOC topology. This method is suitable for different rule libraries in Deep packet inspection (DPI) and is easy to change the rule library of regex stored in memory. The engine was designed and implemented based on field programming gate array (FPGA) as a prototype and a model to implement the architecture in Application-Specific Integrated Circuits (ASIC) is also discussed in this paper. The experimental results show that this method can make regex matching much faster than traditional methods.
, of Monetary Gains and Losses The Medial Frontal Cortex and the Rapid Processing

http://www.sciencemag. org/cgi/content/full/295/5563/2279 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag. org/cgi/content/full/295/5563/2279/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://www.sciencemag. org/cgi/content/full/295/5563/2279#related-content http://www.sciencemag. org/cgi/content/full/295/5563/2279#otherarticles , 6 of which can be accessed for free: cites 23 articles This article 188 article(s) on the ISI Web of Science. cited by This article has been http://www.sciencemag. org/cgi/content/full/295/5563/2279#otherarticles 31 articles hosted by HighWire Press; see: cited by This article has been http://www.sciencemag. org/cgi/collection/neuroscience Neuroscience : subject collections This article appears in the following
Update consistency in software-defined networking based multicast networks

When applying updates on distributed network elements with SDN, intra-update states may violate desired network properties, such as drop- and loop-freeness. Current stateless approaches cannot guarantee the constancy of arbitrary network invariants (correctness) in general, yet update procedures guaranteeing certain invariants do exist. In this paper, we investigate on update consistency for the case of multicast routing and show that there is no correct update procedure w.r. t. both drop- and duplicate-freeness. We show that certain updates of multicast routes inherently raise a concurrency issue, which necessarily results in the occurrence of either drops or duplicates. Furthermore, we present a generic update procedure for multicast routing updates that identifies concurrency-relevant update steps. This procedure allows for the selection of an update strategy, such that either drops or duplicates are avoided. These effects can severely degrade network performance or quality of experience. To investigate the implications of drops and duplicates, we evaluate their frequencies and impact for wide-area network scenarios both, analytically and empirically, through direct measurement in the data plane under update.
Labor Allocation in Paid Crowdsourcing: Experimental Evidence on Positioning, Nudges and Prices

This paper reports the results of a natural field experiment where workers from a paid crowdsourcing environment selfselect into tasks and are presumed to have limited attention. In our experiment, workers labeled any of six pictures from a 2 × 3 grid of thumbnail images. In the absence of any incentives, workers exhibit a strong default bias and tend to select images from the top-left ("focal") position; the bottomright ("non-focal") position, was the least preferred. We attempted to overcome this bias and increase the rate at which workers selected the least preferred task, by using a combination of monetary and non-monetary incentives. We also varied the saliency of these incentives by placing them in either the focal or non-focal position. Although both incentive types caused workers to re-allocate their labor, monetary incentives were more effective. Most interestingly, both incentive types worked better when they were placed in the focal position and made more salient. In fact, salient non-monetary incentives worked about as well as non-salient monetary ones. Our evidence suggests that user interface and cognitive biases play an important role in online labor markets and that salience can be used by employers as a kind of "incentive multiplier".
Strategic fit in transitional economies: The case of China’s electronics industry

The strategic fit paradigm, originally derived from observations in market-based economies, asserts that an appropriate match between environment and strategy has significant and positive implications for business performance. Based on a random sample of Chinese electronics firms, this study systematically examines the applicability of the strategic fit paradigm in China’s centrally planned economy in transition. Results indicate that while environment-strategy coalignment is evident, coalignment only improves performance under certain environmental conditions.
Detection of laughter in children's speech using spectral and prosodic acoustic features

Laughter is an important para-linguistic cue that can be useful in gauging the affective state of the speaker. In this paper, we present an approach to detecting laughter in children’s speech using acoustic features in the spectral and prosodic domains. Feature selection was performed using the information gain-based technique and a speaker-independent validation using a support vector machine (SVM), an accuracy of 94.43% was observed, which was a 12.48% absolute improvement over the baseline result of 81.95%. For us to explore generalization properties, the models of speech and laughter were tested on a completely different database of adult-child interactions known as the Multimodal Dyadic Behavior Dataset (MDBD). The accuracy using the earlier trained models was 70.58%. Even though the children in this database were toddlers (less than three years old), the results suggest that the predictive power of the selected features generalizes well to different forms of children’s laughter.
Performance evaluations of ICI cancellation schemes in OFDM systems

OFDM is a successful technique in wireless communication system. Frequency offset in OFDM systems leads to loss of orthogonality among subcarriers, which resulted in intercarrier interference (ICI) to occur. Another main problem of OFDM is the occurrence of high PAPR. To mitigate ICI problem, ICI self-cancellation scheme and frequency domain partial response coding has been proposed. In this paper, we evaluate the performance of ICI self-cancellation schemes and the integer-coefficients partial response coding (PRC). ICI self-cancellation data allocation of (Xk, Xk+1 = -Xk*) has the best PAPR performance while the data allocation of (Xk, Xk+1 = -Xk*) has the most CIR enhancement. The integer coefficients PRC outperform the ICI self-cancellation schemes in terms of bandwidth efficiency and in the BER performance especially at high ES/NO
The Design and Implementation of Face Tracking in Real Time Multimedia Recording System

This paper proposed a multi-view face tracking system in Multimedia Teaching Recording System. It combines AdaBoost face detection algorithm and CamShift tracking algorithm by taking AdaBoost algorithm as initial face location and CamShift algorithm as follow-up frames tracking, thus construct an effective and practical face tracking system which is very suitable for the Multimedia Teaching System. The experimental results show this system performs very well in real time face tracking, and it achieves a high tracking rate at 20 frames per second.
Lower Bounds Optimization for Coordinated Linear Transmission Beamformer Design in Multicell Network Downlink

We consider the coordinated downlink beamforming problem in a cellular network with the base stations (BSs) equipped with multiple antennas, and with each user equipped with a single antenna. The BSs cooperate in sharing their local interference information, and they aim at maximizing the sum rate of the users in the network. A set of new lower bounds (one bound for each BS) of the non-convex sum rate is identifie d. These bounds facilitate the development of a set of algorithms that allow the BSs to update their beams by optimizing their respective lower bounds. We show that when there is a single user per-BS, the lower bound maximization problem can be solved exactly with rank-1 solutions. In this case, the overall sum rate maximization problem can be solved to a KKT point. Numerical results show that the proposed algorithms achieve high system throughput with reduced backhaul information exchange among the BSs. I. I NTRODUCTION
The optimal volume of 0.2% ropivacaine required for an ultrasound-guided stellate ganglion block

Background This study was performed to find the optimal volume of local anesthetics needed for a successful ultrasound-guided stellate ganglion block (SGB) to treat head and neck pathology. Methods Fifteen female and fourteen male sensory-neural hearing loss patients received 4 times SGBs with 0.2% ropivacaine in volumes of 6, 4, 3 and 2 ml at 1 to 3 day intervals. Using the transverse short-axis view of the neck that showed Chassaignac's tubercle at the C6 level, a 25-gauge, and 4 cm needle was inserted via the lateral paracarotid approach with out-of-plane targeting between the prevertebral fascia and the ventral surface of longus colli muscle (subfascial injection). A successful block was confirmed with the onset of ptosis (Horner's syndrome). Results There were no significant statistical differences between the presence of Horner's syndrome and the volume of local anesthetics given. However, Horner's syndrome was present in all trials for the 4 ml and 6 ml groups. Six (20.7%) and three out (10.4%) of twenty-nine trials in the 2 ml and 3 ml groups, respectively, failed to elicit Horner's syndrome. The duration of action was significantly different in the 2 ml group compared to that of the 6 ml group, but there was no significant difference between the other groups, including the 4 ml vs. 6 ml groups. The side effects were not different between the groups. Conclusions This data suggests that the optimal volume of 0.2% ropivacaine for ultrasound-guided SGB to treat the head and neck pathology in daily practice is 4 ml.
An Examination of Psychometric Properties of Positive Functional Attitudes Scale

The aim of this study is to investigate the applicability of Coping Attitudes Scale: Measure of Positive Attitudes in Depression (CAS) among Turkish young adult community sample and determine the psychometric properties (validity and reliability) of this scale. This study was conducted with 419 students attending different departments in Mugla Sitki Kocman University, Faculty of Education in the spring semester of academic year of 2015-2016. Positive Functional Attitudes Scale, Beck Depression Scale, Beck Hopelessness Scale, Automatic Thoughts Scale, Positivity Scale and Developed Automatic Thoughts Scale.were used as data collection tools. Confirmatory factor analysis (CFA) were used for investigation of the psychometric properties of the PFAS. Also, criterion-related validity, test-retest validity, and internal consistency were used calculated. The CFA results showed that standardized item estimates of the CAS ranged between 0.45 and 0.47. Also the CFA results showed that the original factor structure of the PFAS confirmed on the Turkish sample. internal consistency was calculated using the total community samples PFAS score. Cronbachs alpha coefficient ort he total scale (.93) was high. Test-retest results of the subscales were 0.76. The findings showed that factor structures of the PFAS life perspective, personal accomplishment, positive future, self-worth, coping with problems had psychometric quality in Turkish version. As a result of the study, the Turkish version of PFAS has good validity and reliability for young adult community sample.
Closed subsets of the weyl alcove and tqfts

For an arbitrary simple Lie algebra g and an arbitrary root of unity q, we classify the closed subsets of the Weyl alcove of the quantum group Uq(g). Here a closed subset is a set such that if any two weights in the Weyl alcove are in the set, so is any weight in the Weyl alcove which corresponds to an irreducible summand of the tensor product of a pair of representations with highest weights the two original weights. The ribbon category associated to each closed subset admits a ? quotient? by a trivial subcategory as described by Bruguieres and Muger, to give a modular category and a framed three-manifold invariant or a spin modular category and a spin three-manifold invariant, as proved by the author. Most of these theories are equivalent to theories defined in Sawin, Adv. Math. 165 (2002), 1? 70, but several exceptional cases represent the first nontrivial examples of theories that contain noninvertible trivial objects, making the theory much richer and more complex.
Improved linear discriminant analysis based on two-dimensional Gabor for palmprint recognition

In this paper, a method of Gabor plus improved two-dimensional linear discriminant (Gabor+I2DLDA) which is a improved 2DLDA method by integrating the Gabor wavelet representation of palm images is proposed. Traditional two-dimensional linear discriminant (2DLDA) method eliminates the column relevance of the image, while improved 2DLDA is a direct 2DLDA method which is defined in the traditional 2DLDA basis. In this approach, the Gabor wavelets are used to extract palmprint features. The proposed Gabor+I2DLDA yields greater palmprint recognition accuracy while reduces the dimension. The effectiveness of the proposed algorithm is also verified using the PolyU palmprint databases for palmprint recognition.
Modeling of a high speed network to maximize throughputperformance : the experience of BIP over MyrinetLoic

High speed networks are now providing incredible performances. Software evolution is slow and the old protocol stacks are no longer adequate for these kind of communication speed. When throughput increases, the latency should decrease as much in order to keep the system balance. With the current network technology, the main bottleneck is most of the time the software that makes the interface between the hardware and the user. We designed and implemented new protocols of transmission targeted rst to parallel computing that squeeze the most out of the high speed Myrinet network, giving all the speed to the applications. A precise modeling of the high speed hardware was necessary to analytically determine the optimal pipelines parameters. This modeling and design is presented here as well as experimental results that lead to achieve real Gigabit/s throughput and less than 5s latency with half of the best performance (n 1=2) for 4KBytes messages on a cluster of PC workstations with this network hardware. Moreover, our networking results compare favorably with the expensive parallel computers or ATM LANs.
A decision support model for dairy farms.

Dairy is the main sector of the Azorean economy and it is much influenced by PAC (Common Agricultural Policy). The main objective of this paper is to estimate the objectives that limit the decision making process for the Azorean dairy farms that exist regarding the different grazing systems. Then, we apply a utility model based on multicriteria models, to develop the decision models for Azorean dairy farms. Here the farmers`behavior is not explained by gross margin maximization but by a utility function with several conflicting objectives. The results show that the farmsòbjectives depend on the intensity of grazing systems. In this paper, we show that the traditional objective (income) is not very important, at least for two groups of farmers. Only in the less intensity grazing systems the income seems to be significant.
Markup of a Test Suite with SGML

Recently, there have been various attempts to set up a test suite covering the syntactic phenomena of a natural language (cp. [Flickinger et al. 1989], [Nerbonne et al. 1993]). The latest effort is the TSNLP project (Test Suite for Natural Language Processing) within the Linguistic Research and Engineering (LRE) framework sponsored by the European Union (cp. [Balkan et al. 1994]). These test suites are meant for the testing of NLP software regarding their coverage of syntactic phenomena. [Volk 1995] showed that a well-organised test suite can also be used to support incremental grammar development and grammar documentation. The key issues in the organisation of a test suite are the ease of extensibility and interchangeability as well as the avoidance of redundancy. We have implemented a test suite, which is optimized for the avoidance of redundancy and we report on the trade-off for extensibility and interchangeability.