Miracle-dz/UniFAR-FTUs huggingface dataset:
Towards an integrated information environment with open hypermedia systems

This paper examines open hypermedia systems and presents the case that such systems provide a step forward for dealing with large, dynamic data sets in distributed, heterogeneous environments by allowing users to access and integrate information and processes in richer and more diverse ways than has previously been possible. In particular, the enhanced Microcosm model for open hypermedia is examined, and the ways in which it provides such an environment are discussed. The paper continues by investigating the advantages and the shortcomings of this model and identifies the areas in which further work must be completed before such systems can become widely adopted, such as the granularity of source and destination anchors, editing and version control. Some attempts to provide solutions to these problems are presented and discussed.
The electrical properties of filled and unfilled commercial epoxy resins

An investigation of an epoxy resin of the type used in electrical machines filled with various concentrations of ZnO or Al/sub 2/O/sub 3/ has been made using current transient measurements. It is shown that the addition of either aluminium oxide or zinc oxide filler can produce a composite material with a nonlinear resistivity characteristic when subjected to electric fields up to 11 kVmm/sup -1/.
Apocynin, NADPH oxidase, and vascular cells: a complex matter.

Apocynin (4-hydroxy-3-methoxyacetophenone), isolated from the traditional medicinal plant Picrorhiza kurroa , is a naturally occurring methoxy-substituted catechol, experimentally used as an inhibitor of reduced nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase.1 Activated neutrophil NADPH oxidase, a multisubunit complex composed of membrane-associated gp91phox (Nox2) and p22phox and cytosolic subunits, p47phox, p67phox, and p40phox, produces superoxide anion, a precursor of microbicidal reactive oxygen species (ROS), thereby playing a crucial role in host defense. Apocynin inhibits the release of superoxide anion by NADPH oxidase by blocking migration of p47phox to the membrane, critically involved in initiating assembly of the functional NADPH oxidase complex.1 The underlying chemistry of apocynin’s actions has been elucidated in phagocytic cells.2 Apocynin needs to be activated (oxidized) for it to inhibit the oxidase. In the presence of H2O2 and myeloperoxidase (MPO), abundant in neutrophils, apocynin is oxidized and has as products dimer and trimer derivatives resulting in diapocynin formation, the metabolically active compound of apocynin. The reactivity of apocynin radical with thiol compounds is possibly the mechanism involved in the inhibitory effect of apocynin on the NADPH oxidase complex.2,3 In the early 1990s, with the discovery that cardiovascular cells possess functionally active NADPH oxidase critically involved in ROS generation and oxidative stress in the vascular wall, many investigators extended neutrophil findings and used apocynin as a pharmacological agent to specifically inhibit the vascular cell oxidase. Convincing data from numerous in vitro studies demonstrated that, in endothelial cells, vascular smooth muscle cells, and adventitial fibroblasts, apocynin blocks NADPH oxidase activity and superoxide anion generation.4,5 In vivo studies, in which mice and …
Implantable Cardioverter-Defibrillators in Tetralogy of Fallot

Background— Tetralogy of Fallot is the most common form of congenital heart disease in implantable cardioverter-defibrillator (ICD) recipients, yet little is known about the value of ICDs in this patient population. Methods and Results— We conducted a multicenter cohort study in high-risk patients with Tetralogy of Fallot to determine actuarial rates of ICD discharges, identify risk factors, and characterize ICD-related complications. A total of 121 patients (median age 33.3 years; 59.5% male) were enrolled from 11 sites and followed up for a median of 3.7 years. ICDs were implanted for primary prevention in 68 patients (56.2%) and for secondary prevention in 53 (43.8%), defined by clinical sustained ventricular tachyarrhythmia or resuscitated sudden death. Overall, 37 patients (30.6%) received at least 1 appropriate and effective ICD discharge, with a median ventricular tachyarrhythmia rate of 213 bpm. Annual actuarial rates of appropriate ICD shocks were 7.7% and 9.8% in primary and secondary prevention, respectively (P=0.11). A higher left ventricular end-diastolic pressure (hazard ratio 1.3 per mm Hg, P=0.004) and nonsustained ventricular tachycardia (hazard ratio 3.7, P=0.023) independently predicted appropriate ICD shocks in primary prevention. Inappropriate shocks occurred in 5.8% of patients yearly. Additionally, 36 patients (29.8%) experienced complications, of which 6 (5.0%) were acute, 25 (20.7%) were late lead-related, and 7 (5.8%) were late generator-related complications. Nine patients died during follow-up, which corresponds to an actuarial annual mortality rate of 2.2%, which did not differ between the primary and secondary prevention groups. Conclusions— Patients with tetralogy of Fallot and ICDs for primary and secondary prevention experience high rates of appropriate and effective shocks; however, inappropriate shocks and late lead-related complications are common.
In vitro evaluation of canine and feline calcium oxalate urolith fragility via shock wave lithotripsy.

OBJECTIVE To test the hypothesis that feline calcium oxalate uroliths are intrinsically more resistant to comminution via shock wave lithotripsy (SWL) than canine calcium oxalate uroliths through comparison of the fragility of canine and feline uroliths in a quantitative in vitro test system. SAMPLE POPULATION Calcium oxalate uroliths (previously obtained from dogs and cats) were matched by size and mineral composition to create 7 pairs of uroliths (1 canine and 1 feline urolith/pair). PROCEDURE Uroliths were treated in vitro with 100 shock waves (20 kV; 1 Hz) by use of an electrohydraulic lithotripter. Urolith fragmentation was quantitatively assessed via determination of the percentage increase in projected area (calculated from the digital image area of each urolith before and after SWL). RESULTS After SWL, canine uroliths (n = 7) fragmented to produce a mean +/- SD increase in image area of 238 +/- 104%, whereas feline uroliths (7) underwent significantly less fragmentation (mean image area increase of 78 +/- 97%). The post-SWL increase in fragment image area in 4 of 7 feline uroliths was < 50%, whereas it was > 150% in 6 of 7 canine uroliths. CONCLUSIONS AND CLINICAL RELEVANCE Results indicate that feline calcium oxalate uroliths are less susceptible to fragmentation via SWL than canine calcium oxalate uroliths. In some cats, SWL may not be efficacious for fragmentation of calcium oxalate nephroliths or ureteroliths because the high numbers of shock waves required to adequately fragment the uroliths may cause renal injury.
Recognition Using Hybrid Classifiers

A canonical problem in computer vision is category recognition (e.g., find all instances of human faces, cars etc., in an image). Typically, the input for training a binary classifier is a relatively small sample of positive examples, and a huge sample of negative examples, which can be very diverse, consisting of images from a large number of categories. The difficulty of the problem sharply increases with the dimension and size of the negative example set. We propose to alleviate this problem by applying a “hybrid” classifier, which replaces the negative samples by a prior, and then finds a hyperplane which separates the positive samples from this prior. The method is extended to kernel space and to an ensemble-based approach. The resulting binary classifiers achieve an identical or better classification rate than SVM, while requiring far smaller memory and lower computational complexity to train and apply.
Review on Electroluminescence Behaviour of Organic Light Emitting Diode

In this paper report a review on electroluminescent efficiency using a deoxyribonucleic acid (DNA) complex as an electron blocking layer (EBL) material in emitting organic light emitting diode (OLED). The resulting called BioLED showed a high luminous efficiency. The DNA-based BioLED was as much more efficient and brighter than their OLED counterparts. It is found the effect of EBL is to increase the device turn-on voltage for OLED structure. This is attributed to the fact that the DNA complex increases the series resistance of the device which is turn reduces the current through the device.
Thyroid function and clinical outcomes in kidney failure.

Thyroid hormone synthesis is finely tuned to respond to the variable energy needs of the human body ([1][1]). This process is controlled by two fundamental mechanisms. The first, based on the thyroid-stimulating hormone (TSH)–thyroxine (T4) and triiodothyronine (T3) feed-back loop, constitutes a
Ocular pharmacoscintigraphic and aqueous humoral drug availability of ganciclovir-loaded mucoadhesive nanoparticles in rabbits

Abstract The present report describes the improved ocular retention and aqueous humoral drug availability of ganciclovir (GCV) when administered via topical instillation of different kind of nanoparticles onto the rabbit eye. GCV was loaded into PLGA nanoparticles, chitosan-coated nanoparticles and chitosan-coated niosomal nanoparticles. All three formulations contained nanoparticles equally round in shape with a mean particle size in the range of 180–200 nm. The ocular corneal retention property was evaluated by gamma scintigraphy, revealing that the clearance was slowest in the case of the chitosan-containing formulations. GCV in chitosan-coated PLGA nanoparticles and chitosan-coated niosomal nanoparticles showed approx. 6-fold higher aqueous humor drug availability as compared to a GCV solution and nearly 2.5-fold higher as compared to the chitosan-lacking GCV-PLGA nanoparticles. The results indicate that the use of a mucoadhesive chitosan coating can improve the ocular residence time and aqueous humoral availability of GCV when administered topically in nanoparticles.
On the nature of stress fractures

It is felt that stress fractures are caused by excessive, repetitive muscle forces acting across the affected bone. These fractures should be suspected in participants of athletic endeavors who present with a history of persistent, focal, activity-related pain regardless of their stage of physical conditioning. Associated physical findings are localized tenderness and swelling without evidence of a generalized systemic response. Bone scans and serial roentgenograms including specialized views may be required for documentation. Limitation of the athletic activity is the hallmark of the treatment program.
Cavitation in an orifice flow

The purpose of this study is to identify the potential locations for cavitation induced by total stress on the flow of a liquid through an orifice of an atomizer. A numerical simulation of two-phase incompressible flow is conducted in an axisymmetric geometry of the orifice for Reynolds numbers between 100 and 2000. The orifice has a rounded upstream corner and a sharp downstream corner with length-to-diameter ratio between 0.1 and 5. The total stress including viscous stress and pressure has been calculated in the flow field and, from there, the maximum principal stress is found. The total-stress criterion for cavitation is applied to find the regions where cavitation is likely to occur and compared with those of the traditional pressure criterion. Results show that the viscous stress has significant effects on cavitation. The effect of geometry and occurrence of hydraulic flip in the orifice on the total stress are studied. The Navier-Stokes equations are solved numerically using a finite-volume method .
Affective Computing Experiments in Virtual Reality with Wearable Sensors. Methodological considerations and preliminary results

A ective computing (AfC) is a novel paradigm originally proposed in 1997 by Rosalind Picard from MIT Media Lab in her paramount book [12]. It builds on the results of biomedical engineering and psychology and aims at allowing computer systems to detect, use, and express emotions [4]. While at rst sight it may look general from the computer science point of view, in fact it is a constructive and practical approach oriented mainly at improving human-like decision support as well as human-computer interaction. AfC is a eld of study that puts interest in design and description of systems that are able to collect, interpret, process (ultimately simulate) emotional states (a ects). We assume that emotions are physical and cognitive [12, p.21] and as such they can be studied interdisciplinary by computer science, biomedical engineering and psychology. For a ective computing there are two crucial elements to be considered: modes of data collection and ways of interpreting them in correlation with a ective states corresponding to emotions. First is carried out by selection of methods for detecting information about emotions this means using various sensors which capture data about human physical states and behaviors. Today most often harvested and processed information are about: speech (prosody: pitch variables, speech rate), body gestures and poses (3D mapping, motion capture techniques), facial expressions (visual analysis and electromyography), physiological monitoring (blood pressure, blood volume pulse, galvanic skin response). In our work we plan to use a range of wearable physiological sensors, namely the Empatica E4. It is an advanced sensor based on the technologies previously developed in the A ective Computing division of MIT Media Lab . Moreover, it was used
Intra-laminar Damage Evolution in a Composite Grid Structure Representative Volume Element under Compression Load

In this paper the mechanical behavior of composites grid structures has been numerically investigated. The evolution of fibers and matrix cracking has been simulated by adopting a progressive damage approach. The Hashin failure criteria and ply properties degradation rules have been adopted to simulate the degradation at ply level. Non-linear analyses on a Representative Volume Element of the composite grid structure have been performed to account for its compression behavior.
Multidimensional Convergence in Future 5G Networks

Future 5G services are characterised by unprecedented need for high rate, ubiquitous availability, ultralow latency, and high reliability. The fragmented network view that is widespread in current networks will not stand the challenge posed by next generations of users. A new vision is required, and this paper provides an insight on how network convergence and application-centric approaches will play a leading role toward enabling the 5G vision. This paper, after expressing the view on the need for an end-to-end approach to network design, brings the reader into a journey on the expected 5G network requirements and outlines some of the work currently carried out by main standardisation bodies. It then proposes the use of the concept of network convergence for providing the overall architectural framework to bring together all the different technologies within a unifying and coherent network ecosystem. The novel interpretation of multidimensional convergence we introduce leads us to the exploration of aspects of node consolidation and converged network architectures, delving into details of optical-wireless integration and future convergence of optical data centre and access-metro networks. We then discuss how ownership models enabling network sharing will be instrumental in realising the 5G vision. This paper concludes with final remarks on the role SDN will play in 5G and on the need for new business models that reflect the application-centric view of the network. Finally, we provide some insight on growing research areas in 5G networking.
The Proximal Region of the 3′-Untranslated Region of Cyclooxygenase-2 is Recognized by a Multimeric Protein Complex Containing HuR, TIA-1, TIAR, and the Heterogeneous Nuclear Ribonucleoprotein U*

Cyclooxygenase-2 (COX-2) is an early response gene induced in renal mesangial cells by interleukin-1β (IL-1β). The 3′-untranslated region (3′-UTR) of COX-2 mRNA plays an important role in IL-1β induction by regulating message stability and translational efficiency. The first 60 nucleotides of the 3′-UTR of COX-2 are highly conserved and contain multiple copies of the regulatory sequence AUUUA. Introduction of the 60-nucleotide sequence into the 3′-UTR of a heterologous reporter gene resulted in a 70% decrease in reporter gene expression. Electrophoretic mobility shift assays (EMSAs) demonstrated that mesangial cell nuclear fractions contain a multimeric protein complex that bound this region of COX-2 mRNA in a sequence-specific manner. We identified four members of the protein-RNA complex as HuR, TIA-1, TIAR, and the heterogeneous nuclear ribonucleoprotein U (hnRNP U). Treatment of mesangial cells with IL-1β caused an increase in cytosolic HuR, which was accompanied by an increase in COX-2 mRNA that co-immunoprecipitated with cytosolic HuR. Therefore, we propose that HuR binds to the proximal region of the 3′-UTR of COX-2 following stimulation by IL-1β and increases the expression of COX-2 mRNA by facilitating its transport out of the nucleus.
Modeling and analysis of coexisting multiple radio access technologies in heterogeneous wireless networks

This paper introduces a stochastic geometry framework for modeling and analysis of a heterogeneous wireless network with cellular and WiFi radio access technologies (RATs). Our focus here is to study the coexistence performance of the cellular and WiFi subnetworks in the WiFi frequency spectrum (band). The cellular subnetwork consists of macro and small cell access points (APs) with WiFi spectrum access. We first define the coexisting success probability in the WiFi frequency band as the sum of the density-weighted success probabilities of two subnetworks. The closed-form coexisting success probability is found and it is shown to have the concavity over the number of channels in the WiFi frequency band. The optimal deployment densities of small cell and WiFi access points (APs) that maximize the coexisting success probability are shown to exist and found under the derived constraint on network parameters. We then define the coexisting throughput as the sum of the throughputs of the two subnetworks and claim its unique maximum can be attained by the appropriate setting of AP densities. Numerical results indicate that the coexisting throughput is significantly higher than the throughput when only WiFi APs can access the WiFi frequency band.
Amino acid sequence of a new mitochondrially synthesized proteolipid of the ATP synthase of Saccharomyces cerevisiae.

The purification and the amino acid sequence of a proteolipid translated on ribosomes in yeast mitochondria is reported. This protein, which is a subunit of the ATP synthase, was purified by extraction with chloroform/methanol (2/1) and subsequent chromatography on phosphocellulose and reverse phase h.p.l.c. A mol. wt. of 5500 was estimated by chromatography on Bio‐Gel P‐30 in 80% formic acid. The complete amino acid sequence of this protein was determined by automated solid phase Edman degradation of the whole protein and of fragments obtained after cleavage with cyanogen bromide. The sequence analysis indicates a length of 48 amino acid residues. The calculated mol. wt. of 5870 corresponds to the value found by gel chromatography. This polypeptide contains three basic residues and no negatively charged side chain. The three basic residues are clustered at the C terminus. The primary structure of this protein is in full agreement with the predicted amino acid sequence of the putative polypeptide encoded by the mitochondrial aap1 gene recently discovered in Saccharomyces cerevisiae. Moreover, this protein shows 50% homology with the amino acid sequence of a putative polypeptide encoded by an unidentified reading frame also discovered near the mitochondrial ATPase subunit 6 gene in Aspergillus nidulans.
Managing availability: Supporting lightweight negotiations to handle interruptions

Interruptions are a central aspect of working life. The prevalence of remote co-workers and the use of mobile technology mean that interruptions are more prevalent, and workers have to learn to manage availability. To understand general issues in availability management, we carried out a naturalistic study of how interruptions are handled in face-to-face situations. We found that availability management requires negotiation, that it is also highly dependent on awareness about the availability of others, and that it demands cognitive effort to shift attention to the interruption. On the basis of these observations, we developed a technology, named. The Negotiator, that embodies three main design requirements: (a) support for negotiation, (b) contextual information about when a recipient is available for a call, (c) lightweightness to reduce attention overhead. We carried out an experimental study of interruption management using this technology. The interface satisfied the original design requirements, that is, people, were able to use it effectively to negotiate times to talk, while successfully carrying out an intellectually demanding activity. Contrary to our expectations, however, people preferred to take responsibility for returning calls rather than delegating them, and they preferred to schedule calls as soon as possible rather than deferring them. We suggest that there are social reasons why people do this. They feel a social obligation to return calls as soon as possible so as not to inconvenience others and also to be responsible for making these calls themselves. They also take calls sooner to avoid having to remember future conversational commitments. We discuss the theoretical and technical implications of these findings.
Etodolac, a Cyclooxygenase-2 Inhibitor, Attenuates Paclitaxel-Induced Peripheral Neuropathy in a Mouse Model of Mechanical Allodynia

The effect of the cyclooxygenase-2 (COX-2) inhibitor etodolac on the mechanical allodynia induced by paclitaxel was investigated in mice and compared with the effects of the nonselective COX inhibitors indomethacin and diclofenac, the selective COX-2 inhibitor celecoxib, the calcium channel α2δ subunit inhibitor pregabalin, the sodium channel blocker mexiletine, and the serotonin-norepinephrine reuptake inhibitor duloxetine. The decrease in the paw-withdrawal threshold induced by paclitaxel was reversed by oral administration of etodolac at 10 mg/kg but was not affected by indomethacin, diclofenac, or celecoxib. The antiallodynic effect of etodolac gradually increased during repeated administration, and after 2 weeks the paw-withdrawal threshold at the preadministration point was significantly increased. Pregabalin, duloxetine, and mexiletine also showed an antiallodynic effect in this model. Whereas pregabalin had a preadministration effect similar to that of etodolac during repeated administration, mexiletine or duloxetine had no such effect. There was almost no difference in the distribution of etodolac and diclofenac in nervous tissue, indicating that COX inhibition is unlikely to be involved in the antiallodynic effect of etodolac. Etodolac did not show a neuroprotective effect against morphological transformations such as the axonal degeneration induced by paclitaxel. Instead, etodolac probably acts at the level of functional changes accompanying paclitaxel treatment, such as alterations in the activation state of components of the pain transmission pathway. Our findings suggest that etodolac attenuates paclitaxel-induced peripheral neuropathy by a COX-independent pathway and that it might be useful for the treatment of paclitaxel-induced peripheral neuropathy.