Miracle-dz/UniFAR-FTUs huggingface dataset:
MAGNETO-THERMOHALINE MIXING IN RED GIANTS

We revise a magnetic buoyancy model that has recently been proposed as a mechanism for extra mixing in the radiative zones of low-mass red giants. The most important revision is our accounting of the heat exchange between rising magnetic flux rings and their surrounding medium. This increases the buoyant rising time by five orders of magnitude; therefore, the number of magnetic flux rings participating in the mixing has to be increased correspondingly. On the other hand, our revised model takes advantage of the fact that the mean molecular weight of the rings formed in the vicinity of the hydrogen burning shell has been reduced by 3He burning. This increases their thermohaline buoyancy (hence, decreases the total ring number) considerably, making it equivalent to the pure magnetic buoyancy produced by a frozen-in toroidal field with Bφ ≈ 10 MG. We emphasize that some toroidal field is still needed for the rings to remain cohesive while rising. Besides, this field prevents the horizontal turbulent diffusion from eroding the μ contrast between the rings and their surrounding medium. We propose that the necessary toroidal magnetic field is generated by differential rotation of the radiative zone that stretches a preexisting poloidal field around the rotation axis, and that magnetic flux rings are formed as a result of its buoyancy-related instability.
Moderate (2%, v/v) Ethanol Feeding Alters Hepatic Wound Healing after Acute Carbon Tetrachloride Exposure in Mice

Wound healing consists of three overlapping phases: inflammation, proliferation, and matrix synthesis and remodeling. Prolonged alcohol abuse can cause liver fibrosis due to deregulated matrix remodeling. Previous studies demonstrated that moderate ethanol feeding enhances liver fibrogenic markers and frank fibrosis independent of differences in CCl4-induced liver injury. Our objective was to determine whether or not other phases of the hepatic wound healing response were affected by moderate ethanol after CCl4 exposure. Mice were fed moderate ethanol (2% v/v) for two days and then were exposed to CCl4 and euthanized 24–96 h later. Liver injury was not different between pair- and ethanol-fed mice; however, removal of necrotic tissue was delayed after CCl4-induced liver injury in ethanol-fed mice. Inflammation, measured by TNFα mRNA and protein and hepatic Ly6c transcript accumulation, was reduced and associated with enhanced hepatocyte apoptosis after ethanol feeding. Hepatocytes entered the cell cycle equivalently in pair- and ethanol-fed mice after CCl4 exposure, but hepatocyte proliferation was prolonged in livers from ethanol-fed mice. CCl4-induced hepatic stellate cell activation was increased and matrix remodeling was prolonged in ethanol-fed mice compared to controls. Taken together, moderate ethanol affected each phase of the wound healing response to CCl4. These data highlight previously unknown effects of moderate ethanol exposure on hepatic wound healing after acute hepatotoxicant exposure.
New paradigms for access control in constrained environments

The Internet of Things (IoT) is here, more than 10 billion units are already connected and five times more devices are expected to be deployed in the next five years. Technological standarization and the management and fostering of rapid innovation by governments are among the main challenges of the IoT. However, security and privacy are the key to make the IoT reliable and trusted. Security mechanisms for the IoT should provide features such as scalability, interoperability and lightness. This paper addresses authentication and access control in the frame of the IoT. It presents Physical Unclonable Functions (PUF), which can provide cheap, secure, tamper-proof secret keys to authentify constrained M2M devices. To be successfully used in the IoT context, this technology needs to be embedded in a standardized identity and access management framework. On the other hand, Embedded Subscriber Identity Module (eSIM) can provide cellular connectivity with scalability, interoperability and standard compliant security protocols. The paper discusses an authorization scheme for a constrained resource server taking advantage of PUF and eSIM features. Concrete IoT uses cases are discussed (SCADA and building automation).
The Cochlostoma (Holcopoma) westerlundi group in Italy (Caenogastropoda: Cochlostomatidae)

Currently, the Cochlostoma (Holcopoma) westerlundi (Paulucci, 1879) group includes three subspecies inhabiting southern Italy up to southeastern Sicily. C. w. westerlundi (Paulucci, 1879) is limited to southern Calabria, C. w. yapigium (Westerlund, 1885) is widespread across the Salento (the southeastern extremity of the Apulia region) and C. w. dionysii (Paulucci, 1879) is endemic to the environs of Siracusa (SE Sicily). There is also a fourth taxon, C. paganum (Westerlund, 1885) described for Otranto (LE, Apulia), considered a synonym of C. w. yapigium. Up to now, the molecular genetics of C. westerlundi s.l. have been unknown and the morphological data of several populations are still lacking. Hence, the systematic classification of the group is tentative. Aiming at filling this gap, mtDNA (16S rDNA and COI) partial sequences were investigated and, in addition, the reproductive apparatus of C. w. westerlundi was described for the first time. Molecular sequences and anatomical data were used to test the taxonomic and phylogenetic status of the examined populations. Maximum Likelihood and Bayesian analysis revealed three clusters, strongly supported, corresponding to the three taxa. For the first time, synonymy between paganum and yapigium was confirmed by molecular evidence. Genetic distances between groups (DxyJC) ranged from 2.6% to 5% (16S rDNA) and from 6.3% to 8.3% (COI). Molecular and morphological data led us to suggest elevating the three subspecies to the species rank.
Synovial fluid chondroitin and keratan sulphate epitopes, glycosaminoglycans, and hyaluronan in arthritic and normal knees

OBJECTIVES To determine concentrations of chondroitin sulphate (CS) and keratan sulphate (KS) epitopes, glycosaminoglycans (GAGs) and hyaluronan (HA) in knee synovial fluid (SF) from normal subjects and patients with osteoarthritis (OA) or rheumatoid arthritis (RA), to test whether these variables may be used as markers of the OA process. METHODS OA was subdivided into large joint OA (LJOA), nodal generalised OA (NGOA), and OA with calcium pyrophosphate crystal deposition (CPA). Clinical assessment of inflammation (0-6) was undertaken on OA and RA knees. Knee SF was examined by enzyme linked immunosorbent assay for: CS epitopes, using monoclonal antibodies 3-B-3 and 7-D-4; KS epitope using monoclonal antibody 5-D-4; and HA, using biotinylated HA binding region of cartilage proteoglycan. Total sulphated GAGs were measured by dye binding with 1:9 dimethylmethylene blue. RESULTS Increased SF 3-B-3 concentrations and 3-B-3/GAG ratio were found in OA, compared with RA or normal knees, with higher 3-B-3 and 3-B-3/GAG in LJOA and NGOA than in CPA. SF 7-D-4 and 7-D-4/GAG were reduced in RA, compared with normal and OA; SF 5-D-4 was reduced in OA compared with normal. GAG and HA concentrations were decreased in both OA and RA. No correlations with radiographic scores were observed, but SF 7-D-4 was lower in ‘inflamed’ compared with ‘non-inflamed’ RA and OA knees. In patients with bilateral samples there were strong correlations between right and left knees for all SF variables. CONCLUSIONS Changed concentrations of SF CS and KS can be detected in OA with a profile that differs from that seen in RA. Clinical subgrouping and local joint inflammation may influence these measures, supporting different pathogenesis within OA subgroups and requirement for careful patient characterisation in SF studies.
CS 224 W Final Project : Predicting Yelp Ratings From Social Network Data Do ( kelvindo

Yelp is a popular consumer application that has consistently kept itself relevant by integrating business reviews within an extensive social network. While the ability to add friends and internally message other users isn’t as strongly emphasized across the product, the social component of the application helps provide incentive for users contribute to the greater Yelp community. This network community, of both users and businesses creates an invaluable network of information from which future user usage can be modeled. This paper examines the relational Yelp data to make predictions about the actions that users would take on the network specifically to make predictions on their future review scores. Through a study of the communities that exist within the graph and through several different similarity metrics we hope to serve unique predictions about a user’s future review scores based on information made available through network analysis.
Symbiont-induced odorant binding proteins mediate insect host hematopoiesis

Symbiotic bacteria assist in maintaining homeostasis of the animal immune system. However, the molecular mechanisms that underlie symbiont-mediated host immunity are largely unknown. Tsetse flies (Glossina spp.) house maternally transmitted symbionts that regulate the development and function of their host’s immune system. Herein we demonstrate that the obligate mutualist, Wigglesworthia, up-regulates expression of odorant binding protein six in the gut of intrauterine tsetse larvae. This process is necessary and sufficient to induce systemic expression of the hematopoietic RUNX transcription factor lozenge and the subsequent production of crystal cells, which actuate the melanotic immune response in adult tsetse. Larval Drosophila’s indigenous microbiota, which is acquired from the environment, regulates an orthologous hematopoietic pathway in their host. These findings provide insight into the molecular mechanisms that underlie enteric symbiont-stimulated systemic immune system development, and indicate that these processes are evolutionarily conserved despite the divergent nature of host-symbiont interactions in these model systems. DOI: http://dx.doi. org/10.7554/eLife.19535. 001
A Secure Communication Model for Expressive Access Control Using CP-ABE

Attribute Based Encryption is a technique that associates user's attributes with keys. Data is encrypted using a specific policy and only those keys whose attributes satisfy that policy are allowed to decrypt it. In this paper, we propose a secure communication model based on Cipher- text Policy Attribute Based Encryption (CP-ABE). This model allows Role Based Access Control for documents without the use of a secure server to enforce the access policies. We propose a scalable implementation for key re- vocation and user attribute updation with improved flexibility. Our method uses a key revoke-list and key-version to achieve this. We show the implementation using the CP-ABE toolkit, an open source library that implements the CP-ABE scheme. We also show how confidentiality, integrity and source authentication is achieved in our model.
Alternate biological sequence clustering using symbol table

Clustering has to do with the identification of interesting distribution patterns and similarities, natural groupings or clusters, within a collection of objects in a dataset. Clustering is an unsupervised learning problem and can be distance-based or conceptual. In distance-based clustering the similarity criterion is based on distance. Objects belong to the same cluster if they are close according to a given distance. Conceptual clustering defines a concept common to all the objects in the cluster. In this case, objects are clustered based on their fitness to some descriptive concepts, and not according to distance or similarity measure. The extension of the usage of the common symbol table is employed in this paper to the clustering of biological sequences. The method does not depend on concept as does conceptual clustering rather it uses table (hash table or list). The result obtained indicates the usefulness of the symbol table in biological sequence clustering.
Preliminary Study on Cost-Effective L-Tryptophan Production from Indole and L-Serine by E. coli Cells

Background: L-tryptophan is used widespread in the pharmaceutical industry. The majority of L-Trp production depends on microbial processes that produce L-tryptophan from indole and L-serine. These processes are very costly due to the costs of precursors, especially L-serine. Use of inexpensive substitutions as the L-serine source of L-tryptophan production enables us to reach a cost-effective process. In this paper, effect of Triton X-100 on L-Trp production and the ability to use Iranian cane molasses as inexpensive L-serine source was investigated. Methods: Escherichia coli (E. coli) ATCC 11303 cells were grown in 10-L fermenter containing minimal medium supplemented with beet molasses as an inexpensive carbon source and indole as tryptophan synthase inducer. Whole cells of stationary phase were used as biocatalyst for L-Trp production. Triton X-100 addition to the production medium as indole reservoir was investigated. Then, cane molasses was used as L-Ser source in L-Trp production medium. Amount of L-Tryptophan and theoretical yield of L-Trp production was determined by HPLC and by a colorimetrically method on the basis of remaining indole assay, respectively. Results: As a result, triton X-100 increased L-Trp production three times. Also, the result showed that 0.68 mM L-Tryptophan was produced in the presence of cane molasses at 37°C for 8 hr. Conclusion: This result showed that cane molasses of Qazvin sugar factory includes significant amounts of L-Ser that makes it a suitable substitution for L-Ser in L-Trp production. Therefore, it has the potential to be used for cost-effective L-Trp production in industrial scale.
Projection subtypes of rat neostriatal matrix cells revealed by intracellular injection of biocytin

Individual neostriatal-matrix spiny neurons were stained intracellularly with biocytin after intracellular recording in vivo, and their axons were traced into the globus pallidus (GP), entopeduncular nucleus (EP), and/or substantia nigra (SN). The locations of the neurons within the matrix compartment of the neostriatum (NS) were established by immunocytochemical counterstaining of sections containing the cell bodies using antibodies for calbindin- D28K. This allowed nearly complete visualization of the axonal projections of single NS neurons. On the basis of their intrastriatal axonal arborizations, matrix spiny neurons could be divided into 2 types. One type, which was the more common, had local axonal arborizations restricted to the region of the dendritic field, often with axon collaterals arborizing within the dendritic field of the cells of origin. A second, less common, cell type in the matrix had local axon collaterals distributed widely in the NS. Among matrix neurons with restricted local collateral fields, 3 subtypes could be distinguished on the basis of their efferent axonal projections. Type I cells projected only to the GP. Type IIa cells projected to the GP, EP, and SN pars reticulata. Type IIb cells projected to the GP and SN but not to the EP. The shapes and densities of the GP arborizations varied in the 3 cell types, with the cells projecting only to the GP (type I) projecting more heavily and filling a larger volume there than type II cells. The dendrites and intrastriatal axon collaterals of 3 subtypes were similar in morphology. The class of matrix spiny neurons with intrastriatal axon collaterals distributed widely in the NS were observed to project to the GP. Projections beyond the GP were not identified for this cell type, but could not be ruled out. Somatodendritic morphologies of neurons did not differ according to the projection site. These results demonstrate that NS matrix spiny cells are more heterogeneous in their efferent projection patterns than previously suspected on the basis of retrograde axonal tracing and immunocytochemical studies. As predicted by those previous studies, there is a class of matrix neurons that projects only to the GP. Presumably, these cells contain enkephalin. Cells projecting to the SN and EP, and so presumably containing substance P, give off a small projection to the GP, as well, and differ in their collateralization patterns within the 3 major target nuclei.
The Effect of Alert Type to an Interruption on Primary Task Resumption

Interruptions are pervasive; rarely can one work for an extended period of time without being interrupted. One method for reducing the disruptiveness of interruptions is to present an alert prior to the interruption. Based on the Memory for Goals theory (Altmann and Trafton, 2002), this alert period provides an opportunity to maintain an associative link between the suspended primary task goal and relevant environmental cues which facilitates resumption. This theory does not, however, describe what types of alerts are most effective. Using reaction time and eye movement measures, three different types of alerts were examined to determine which alerts were the most effective and to determine which afforded the greatest opportunity to form an associative link between the suspended primary task goal and relevant environmental cues. Alert conditions resulted in faster resumption times than a no alert condition. There were no differences between the alert conditions themselves, despite eye movement differences reflecting cue association processes. The eye movement data suggest that one fixation is enough to form an associative link which reduces the disruptiveness of interruptions.
Muscle Spasms After Chronic Spinal Cord Injury Excitability , Sensory Synaptic Transmission and Adrenergic Receptors Modulate Motoneuron

[PDF] [Full Text] [Abstract] , April , 2011; 105 (4): 1835-1849. J Neurophysiol Brian R. Noga, Dawn M. G. Johnson, Mirta I. Riesgo and Alberto Pinzon receptors in the thoraco-lumbar spinal cord 2b α or NE 1a α with NE Locomotor-activated neurons of the cat. II. Noradrenergic innervation and colocalization [PDF] [Full Text] [Abstract] , October , 2011; 106 (4): 1652-1661. J Neurophysiol Tanya Onushko, Allison Hyngstrom and Brian D. Schmit reflexes in chronic spinal cord injury Bilateral oscillatory hip movements induce windup of multijoint lower extremity spastic
Soil is an important pathway of human lead exposure.

This review shows the equal or greater importance of leaded gasoline-contaminated dust compared to lead-based paint to the child lead problem, and that soil lead, resulting from leaded gasoline and pulverized lead-based paint, is at least or more important than lead-based paint (intact and not pulverized) as a pathway of human lead exposure. Because lead-based paint is a high-dose source, the biologically relevant dosage is similar to lead in soil. Both lead-based paint and soil lead are associated with severe lead poisoning. Leaded gasoline and lead in food, but not lead-based paint, are strongly associated with population blood lead levels in both young children and adults. Soil lead and house dust, but not lead-based paint, are associated with population blood lead levels in children. Most soil lead and house dust are associated with leaded gasoline. Lead-based paint dust is associated with cases of renovation of either exterior or interior environments in which the paint was pulverized. Based upon the limited data to date, abatement of soil lead is more effective than abatement of lead-based paint in reducing blood lead levels of young children. About equal numbers of children under 7 years of age are exposed to soil lead and lead-based paint. Seasonality studies point to soil lead as the main source of population blood lead levels. Soil lead is a greater risk factor than lead-based paint to children engaged in hand-to-mouth and pica behavior. In summary, soil lead is important for addressing the population of children at risk of lead poisoning. When soil lead is acknowledged by regulators and the public health community as an important pathway of human lead exposure, then more effective opportunities for improving primary lead prevention can become a reality. ImagesFigure 1
Experiment and the Foundations of Quantum Physics

Quantum physics, a child of the early 20th century, is probably the most successful description of nature ever invented by man. The range of phenomena it has been applied to is enormous. It covers phenomena from the elementary-particle level all me way to the physics of the early universe. Many modern technologies would be impossible without quantum physics—witness, for example, that all information technologies are based on a quantum understanding of solids, particularly of semiconductors, or that the operation of lasers is based on a quantum understanding of atomic and molecular phenomena.
Minimally invasive decompression versus open laminectomy for central stenosis of the lumbar spine: pragmatic comparative effectiveness study

Objective To test the equivalence for clinical effectiveness between microdecompression and laminectomy in patients with central lumbar spinal stenosis. Design Multicentre observational study. Setting Prospective data from the Norwegian Registry for Spine Surgery. Participants 885 patients with central stenosis of the lumbar spine who underwent surgery at 34 Norwegian orthopaedic or neurosurgical departments. Patients were treated from October 2006 to December 2011. Interventions Laminectomy and microdecompression. Main outcome measures The primary outcome was change in Oswestry disability index score one year after surgery. Secondary endpoints were quality of life (EuroQol EQ-5D), perioperative complications, and duration of surgical procedures and hospital stays. A blinded biostatistician performed predefined statistical analyses in unmatched and propensity matched cohorts. Results The study was powered to detect a difference between the groups of eight points on the Oswestry disability index at one year. 721 patients (81%) completed the one year follow-up. Equivalence between microdecompression and laminectomy was shown for the Oswestry disability index (difference 1.3 points, 95% confidence interval −1.36 to 3.92, P<0.001 for equivalence). Equivalence was confirmed in the propensity matched cohort and full information regression analyses. No difference was found between groups in quality of life (EQ-5D) one year after surgery. The number of patients with complications was higher in the laminectomy group (15.0% v 9.8%, P=0.018), but after propensity matching for complications the groups did not differ (P=0.23). The duration of surgery for single level decompression was shorter in the microdecompression group (difference 11.2 minutes, 95% confidence interval 4.9 to 17.5, P<0.001), but after propensity matching the groups did not differ (P=0.15). Patients in the microdecompression group had shorter hospital stays, both for single level decompression (difference 1.5 days, 95% confidence interval 1.7 to 2.6, P<0.001) and two level decompression (0.8 days, 1.0 to 2.2, P=0.003). Conclusion At one year the effectiveness of microdecompression is equivalent to laminectomy in the surgical treatment of central stenosis of the lumbar spine. Favourable outcomes were observed at one year in both treatment groups. Trial registration ClinicalTrials.gov NCT02006901.