Miracle-dz/UniFAR-FTUs huggingface dataset:
Welsh-Medium Teaching in Psychology

Teaching psychology through the medium of Welsh is a new development. It raises important issues relating to methods of teaching the subject, and derives from the desire to provide practising psychologists with the training to be able to better serve the Welsh-speaking population of Wales. This paper outlines the problems with Welsh provision that psychologists are able to offer at present. It provides examples of how the Welsh-speaking population is currently at a disadvantage, and proposes that the development of Welsh-medium teaching offers one way of addressing the problem.
RoutineMaker: Towards end-user automation of daily routines using smartphones

People use smartphones in daily activities for accessing and storing information in various situations. In this paper, we present a work in progress for detecting and automating some of these activities. To explore the possible patterns we developed an experimental application to detect daily tasks used by smartphones and analyzed it to provide suggestions for “routines”. We conducted a two-week user study with 10 users to evaluate the approach. During the study the application logged the usage patterns, sent information to the server where it was analysed and clustered. The participants could also automate their smartphone tasks using the analysed data. The findings suggest that people would be willing to automatize tasks given that the approach gives flexibility and expressiveness without too much information overload. Future work includes refining the algorithms based on the gathered real-life data and modifying the interaction design to approach the challenges found with the initial study.
Alcohol Consumption and Life Satisfaction: Evidence from Russia

Alcohol consumption is known to have an impact on various aspects of individual’s life. This paper is based on the idea that the alcohol consumption is very likely to influence on subjective well-being. Using data from the Russia Longitudinal Monitoring Survey of HSE (RLMS-HSE) in this paper the links between alcohol consumption and subjective well-being is examined. RLMS-HSE data shows that a significant number of individuals consumed alcohol in the last month in Russia, the proportion of men drinkers is extremely high, and is around 60-70%. Two sources of endogeneity are discussed in the paper: individual characteristics, such as one’s value system and traits of character; and the existing environment, for example, a negative macroeconomic situation. Empirical estimates are obtained using probit adapted OLS approach. Results suggest that reasonable consumption of alcohol improves the level of life satisfaction. However, alcohol abuse produces negative effects on life satisfaction. DOI: 10.5901/ajis.2013. v2n8p98
SPECTRAL GEOMETRY AND CAUSALITY

For a physical interpretation of a theory of quantum gravity, it is necessary to recover classical space–time, at least approximately. However, quantum gravity may eventually provide classical space–times by giving spectral data similar to those appearing in noncommutative geometry, rather than by giving directly a space–time manifold. It is shown that a globally hyperbolic Lorentzian manifold can be given by spectral data. A new phenomenon in the context of spectral geometry is observed: causal relationships. The employment of the causal relationships of spectral data is shown to lead to a highly efficient description of Lorentzian manifolds, indicating the possible usefulness of this approach. Connections to free quantum field theory are discussed for both motivation and physical interpretation. It is conjectured that the necessary spectral data can be generically obtained from an effective field theory having the fundamental structures of generalized quantum mechanics: a decoherence functional and a choice of histories.
THE FAMILY JOURNAL: COUNSELING AND THERAPY FOR COUPLES AND FAMILIES / July 2001 Christensen, Brooks / ADULT CHILDREN OF IVORCE

Research that focuses on the long-term effects of divorce indicates a lower sense of well-being and overall quality of life as well as relationship problems for those who experience the divorce of their parents as children. Many researchers have shown that parental divorce affects children long after they are grown and involved in intimate relationships of their own. This article provides a review of research specific to the effects of parental divorce on adults in terms of relationship issues. Specific purposes of this review are to (a) explore research specific to intimacy and marital attitudes in adult children of divorce, (b) inform couple and family counselors of the complex and pervasive effects of parental divorce, and (c) relay implications for effective treatment and future research.
Antiplatelet and Anticoagulation Treatment in Patients With Non–ST-Segment Elevation Acute Coronary Syndrome: Comparison of the Updated North American and European Guidelines

In 2014, the American Heart Association and the American College of Cardiology (AHA/ACC) published their guideline for the management of patients with non–ST-segment elevation acute coronary syndromes (NSTE-ACS), whereas the European Society of Cardiology published their latest guideline for the management of patients with NSTE-ACS in 2011. In this article, we review the main updates in antiplatelet and anticoagulation therapy in the 2014 AHA/ACC guideline and compare them with the 2011 European guidelines. Key recommendations in the AHA/ACC guidelines include the addition of ticagrelor to a broad spectrum of patients with NSTE-ACS, narrowing of the role of prasugrel to patients who undergo coronary stenting, and limiting the use of glycoprotein IIb/IIIa receptor inhibitors mainly to high-risk patients during percutaneous coronary intervention. These modifications bring the North American and the European guidelines closer together. The recommendations regarding anticoagulants still differ between the 2 guidelines, although all 4 parenteral agents (unfractionated heparin, low-molecular-weight heparin, bivalirudin, and fondaparinux) are now considered acceptable by both guidelines. We also review new data from clinical trials that became available after the 2014 guidelines were finalized, including studies with cangrelor, rivaroxaban, vorapaxar, ticagrelor, and long-term use of dual antiplatelets that will be considered in future guidelines. As the 2014 guidelines represent the most comprehensive and authoritative document for the management of patients with NSTE-ACS, clinicians who manage these patients should be familiar with their recommendations to ensure optimal patient care.
Civic Mission and Social Responsibility: New Challenges for the Practice of Public Relations in Higher Education

What is the civic mission of the research university in a modern society? How does it challenge the Public Relations professionals of universities? The Finnish Higher Education Evaluation Council, a specialist organ of the Ministry of Education, has conducted several university evaluations with special emphasis on the regional role of Finnish universities. In February 2004, the Finnish university legislation was changed to include the civic mission as the third basic function of the universities, parallel to research and teaching. This change can be seen as both a challenge and a recognition of the PR professionals of Finnish universities. This article intends to clarify the concept of the civic mission, and to find eventual connections to and similarities with the concept of corporate social responsibility.
Upregulation of renin-angiotensin system during differentiation of monocytes to macrophages.

BACKGROUND We have demonstrated that accumulated macrophages in human coronary arteries strongly express angiotensin converting enzyme in accordance with the development of atheromatous plaques. However, there are few reports on the regulation of the renin-angiotensin system in macrophages and in monocytes as their source. OBJECTIVE To examine whether the renin-angiotensin system is upregulated during the differentiation of monocytes to macrophages, and whether it is further regulated by angiotensin II and cytokines. MATERIALS AND METHODS We used a human leukemia cell line, THP-1, for monocytes. Differentiated THP-1, induced by adding phorbol 12-myristate 13-acetate for 24 h, were used as macrophages. Expression of messenger RNA of the renin-angiotensin system components was measured by quantitative reverse-transcriptase polymerase chain reaction. Angiotensin converting enzyme activity and subtype-specific angiotensin-binding sites of cultured cells, and angiotensin II production in the culture medium were measured. RESULTS Macrophages expressed all components of the renin-angiotensin system except chymase. Cellular angiotensin converting enzyme activity and angiotensin II in the medium were increased 3.2- and 4.5-fold during differentiation, respectively. Expression of angiotensin II type 1 (AT1) and type 2 (AT2) receptors was increased 6.2-and 6.4-fold during differentiation, and was sustained for 7 days. Incubation with angiotensin II for 24 h caused downregulation of both AT1 and AT2 receptor messenger RNA, but the expression levels were still more than threefold higher compared with monocytes. The density of binding sites of AT1 and AT2 receptors in macrophages was 0.26 +/- 0.02 and 0.15 +/- 0.01 fmol/10(6) cells, respectively. CONCLUSION The renin-angiotensin system is markedly activated during monocyte/macrophage differentiation, and may participate in the development of atherosclerosis.
An integrated process for removing the inhibitors of the prehydrolysis liquor of kraft‐based dissolving pulp process via cationic polymer treatment

The prehydrolysis liquor (PHL) of the kraft‐based dissolving pulp production process contains various amounts of hemicelluloses that can be utilized in the production of value‐added products. In this work, a new process was proposed for removing the inhibitors of PHL via employing a flocculation concept to facilitate the utilization of hemicelluloses. Lignin, lignocelluloses/cationic polymer complexes, and possibly ethanol are the main products of this process. This process has been experimentally evaluated with an industrially produced PHL and cationic polymers. The results showed that 16% of lignin, 19% of acetic acid, 43% of furfural, and insignificant amount of sugars were removed from PHL via pretreating PHL with acid and lime at pH 7. Furthermore, by adding 0.4–0.5 mg g−1 polydiallyldimethylammonium chloride (PDADMAC) or chitosan to the pretreated PHL, 12–14% acetic acid, 40–50% furfural, 5–6% monomeric sugars, and 25% oligomeric sugars were removed from the PHL. The complexes made from these components may be applied as organic fillers in various industries. Alternatively, by adding 1.2 or 1.4 mg g−1 PDADMAC or chitosan to the pretreated PHL, 30 or 35% of lignin was removed, respectively, which induced complexes that could be used as a fuel source. The composition of the complexes formed was also determined in this work. © 2012 American Institute of Chemical Engineers Biotechnol. Prog. , 28: 998–1004, 2012
Activity of magnocellular neuroendocrine cells in the hypothalamus of unanaesthetized monkeys

1. We studied magnocellular neuroendocrine cells and non‐neuroendocrine cells in the supraoptic nucleus (n.s.o.) and internuclear zone (i.n.z.) in the hypothalamus of unanaesthetized, chronically prepared monkeys. After antidromic identification, functional cell typing and sensory testing we injected solutions of varying tonicity into an implanted carotid cannula to determine osmosensitivity.
Review: A Primer on Aspects of Cognition for Medical Informatics

As a multidisciplinary field, medical informatics draws on a range of disciplines, such as computer science, information science, and the social and cognitive sciences. The cognitive sciences can provide important insights into the nature of the processes involved in human- computer interaction and help improve the design of medical information systems by providing insight into the roles that knowledge, memory, and strategies play in a variety of cognitive activities. In this paper, the authors survey literature on aspects of medical cognition and provide a set of claims that they consider to be important in medical informatics.
CentroidAlign-Web: A Fast and Accurate Multiple Aligner for Long Non-Coding RNAs

Due to the recent discovery of non-coding RNAs (ncRNAs), multiple sequence alignment (MSA) of those long RNA sequences is becoming increasingly important for classifying and determining the functional motifs in RNAs. However, not only primary (nucleotide) sequences, but also secondary structures of ncRNAs are closely related to their function and are conserved evolutionarily. Hence, information about secondary structures should be considered in the sequence alignment of ncRNAs. Yet, in general, a huge computational time is required in order to compute MSAs, taking secondary structure information into account. In this paper, we describe a fast and accurate web server, called CentroidAlign-Web, which can handle long RNA sequences. The web server also appropriately incorporates information about known secondary structures into MSAs. Computational experiments indicate that our web server is fast and accurate enough to handle long RNA sequences. CentroidAlign-Web is freely available from http://centroidalign.ncrna. org/.
Aging Faces : Learning Facial Growth Models

Developing computational models for human faces that accou nt for different facial appearances due to factors such as illumination variations, head pose variations, varying fa cial expressions, occlusions etc. has long been of interest in the computer vision and psychophysics communities. Human face s convey significant information pertaining to individuals such as their identity, gender, age group, ethnicity etc and further facial expressions often help identify the emotion al state of individuals. Hence perception studies suggest that human f aces are associated with high psychosocial importance and i de tify attributes such as facial attractiveness, facial age etc. a s factors that regulate interpersonal behavior. From a face recognition perspective, numerous algorithms have been developed to pe rform still-image based and video-based face recognition i n the presence of illumination and head pose varitions [ 5]. In this paper, we develop computational models that chara cte ize facial aging effects commonly observed during formative years (0 t o 18 years) and in turn help perform face recognition across a ge progression. During formative years, while shape variations in the crani um are prominent with increase in age, textural variations i n the form of wrinkles and other skin artifacts are minimal. Hence , w address the proposed facial growth model as a craniofaci al growth model : a shape transformation model that characteri zes facial growth observed during formative years by means o f drifts observed in facial features with age. While developin g facial growth models, taking into consideration the follo wing aspects is crucial to the success of the model in characteriz ing facial aging effects :
Loss of Tenomodulin Results in Reduced Self-Renewal and Augmented Senescence of Tendon Stem/Progenitor Cells

Tenomodulin (Tnmd) is a well-known gene marker for the tendon and ligament lineage, but its exact functions in these tissues still remain elusive. In this study, we investigated Tnmd loss of function in mouse tendon stem/progenitor cells (mTSPC) by implicating a previously established Tnmd knockout (KO) mouse model. mTSPC were isolated from control and Tnmd KO tail tendons and their stemness features, such as gene marker profile, multipotential, and self-renewal, were compared. Immunofluorescence and reverse transcriptase-polymerase chain reaction analyses for stem cell-, tenogenic-, osteogenic-, and chondrogenic-related genes confirmed their stemness and lineage specificity and demonstrated no profound differences between the two genotypes. Multipotential was not significantly affected since both cell types differentiated successfully into adipogenic, osteogenic, and chondrogenic lineages. In contrast, self-renewal assays validated that Tnmd KO TSPC exhibit significantly reduced proliferative potential, which was also reflected in lower Cyclin D1 levels. When analyzing possible cellular mechanisms behind the observed decreased self-renewability of Tnmd KO TSPC, we found that cellular senescence plays a major role, starting earlier and cumulating more in Tnmd KO compared with control TSPC. This was accompanied with augmented expression of the cell cycle inhibitor p53. Finally, the proliferative effect of Tnmd in TSPC was confirmed with transient transfection of Tnmd cDNA into Tnmd KO TSPC, which rescued their proliferative deficit. Taken together, we can report that loss of Tnmd affects significantly the self-renewal and senescence properties, but not the multipotential of TSPC.
Towards shorter validation cycles by considering mechatronic component behaviour in early design stages

Nowadays typical validation in the development process of automated production plants includes Virtual Commissioning (VC) to test the control logic against the modelled plant behaviour. To reduce modelling efforts, the generation of models for VC is in practical often based on the existing control logic, e.g. hardware configuration of the PLC (used for automated signal mapping). This results in the limitation of testing at the end of the development process with resulting disadvantages like late detection of errors. In the meantime early automation concept evaluations are mainly done by empirical knowledge due to the lack of reliable models. In this paper we will present a component model and work-flow for coupling a 3D-CAD tool with a behavioural model of a mechatronic component for generating an initial virtual plant model allowing examining the feasibility of the selected components already during the mechanic design phase. The created model could also be used for iterative development of the control logic with an comprehensive VC at the end of the process utilizing the already developed model and thus reducing modelling efforts and enabling shorter validation cycles throughout the whole process.
Experts' Perspectives on the Integration of Indigenous Knowledge and Science in Wet Tropics Natural Resource Management

ABSTRACT Aboriginal inhabitants of the Wet Tropics of Queensland advocate for greater inclusion of their Indigenous knowledge (IK) in natural resource management (NRM) to fulfil their customary obligations to country and to exert their Native Title rights. Despite a legal and institutional framework for inclusion of IK in NRM, IK has so far been applied only sporadically. We conducted an ethnographic case study to investigate perceptions on IK, science and how they affect integration of the two knowledge systems in the Wet Tropics. Our results show that IK and science are perceived as different concepts; that integration is limited by weak Indigenous internal and external governance; and that stronger Aboriginal governance and more focused engagement strategies are required to further the application of IK in local NRM. We conclude by arguing that NRM in the Wet Tropics needs to be reconceptualised to accommodate IK holistically, by considering its epistemology and the values and ethic that underpin it.
A Sense of Connection: Toward Social Constructivist Physical Education

In social constructivist educational theory, the classroom is seen as a community of learners. According to social constructivists, learning occurs through peer interactions, student ownership of the curriculum and educational experiences that are authentic for students. The purpose of this study was to investigate how teachers used social constructivist strategies to encourage student construction of knowledge and meanings, and how students constructed knowledge and meanings in two middle school physical education classrooms. A qualitative naturalistic design was used to collect data over a five-month period with two experienced middle school physical education teachers. Data included 11 weeks of observational field notes and interviews with teachers and students. Data were analyzed using cross-case and inductive analysis. Findings indicated that the teachers' strategies created a learning environment in which students actively constructed knowledge and meanings by making connections to their peers and by connecting physical education to their lives, their communities, and the real world. Students shared information, assumed leadership and responsibility, and became decision-makers. By connecting to their peers, students felt supported in their learning. This study offers additional findings in support of social constructivist pedagogy in physical education that encourages individual growth and social awareness in communities of learners.
A compression technique for analyzing disagreement-based active learning

We introduce a new and improved characterization of the label complexity of disagreement-based active learning, in which the leading quantity is the version space compression set size. This quantity is defined as the size of the smallest subset of the training data that induces the same version space. We show various applications of the new characterization, including a tight analysis of CAL and refined label complexity bounds for linear separators under mixtures of Gaussians and axis-aligned rectangles under product densities. The version space compression set size, as well as the new characterization of the label complexity, can be naturally extended to agnostic learning problems, for which we show new speedup results for two well known active learning algorithms.
Integrated view of genome structure and sequence of a single DNA molecule in a nanofluidic device

We show how a bird’s-eye view of genomic structure can be obtained at ∼1-kb resolution from long (∼2 Mb) DNA molecules extracted from whole chromosomes in a nanofluidic laboratory-on-a-chip. We use an improved single-molecule denaturation mapping approach to detect repetitive elements and known as well as unique structural variation. Following its mapping, a molecule of interest was rescued from the chip; amplified and localized to a chromosome by FISH; and interrogated down to 1-bp resolution with a commercial sequencer, thereby reconciling haplotype-phased chromosome substructure with sequence.
Ionone, Iridoid and Phenylethanoid Glycosides from Ajuga salicifolia

From the aerial parts of Ajuga salicifolia (L.) Schreber, a new ionone glycoside (3β-hydroxy- 7,8-dihydro-4-oxo-β-ionol-9-O-β-ᴅ-glucopyranoside) was isolated, along with the known compounds, corchoionoside C, 8-O-acetylmioporoside, ajugol, harpagide, 8-O-acetylharpagide, lavandulifolioside and leonosides A and B. This is the first report of the occurrence of ionone glycosides and 8-O-acetylmioporoside in Ajuga species. Ajugol, lavandulifolioside, leonoside A and B were isolated for the first time from Ajuga salicifolia. The structures were elucidated by means of 1D-, 2D-NMR spectroscopy, and HR-MALDI mass spectrometry.