Miracle-dz/UniFAR-FTUs huggingface dataset:
Whether Carotenoids and Quercetin Affect the Proliferation andExpression of PPARγ Protein in Leukemia K562 Cells

Carotenoids are some of the most abundant pigments in nature, ranging from yellow to red. Carotenoids can divide intotwo categories: carotenoids composed of hydrocarbon elements and lutein-containing oxygen elements. They are lipidsoluble pigments, and some contain carbonyl or enol groups, which are water-soluble. Carotenoids absorb visible lightfrom 400 nm to 600 nm, while special ones such as octa-hydro lycopene and hexahydrolycopene only absorb ultravioletlight. Quercetin is a flavonoid compound widely found in fruits and vegetables. Its chemical structure phenolic hydroxylgroup is the basis of antioxidant action, which can be used for hydrogen to quench oxygen free radicals. It is oxidizedto form a highly stable catechol structure. It has a variety of biological activities and pharmacological effects, such asexpanding coronary blood vessels and inhibiting tumor cell proliferation. This paper shows that the K562 cell growthrate in carotenoids and quercetin treatment groups was slower than the control group.
Preliminary Assessment of Reference Region Quantification and Reduced Scanning Times for [18F]SynVesT-1 PET in Parkinson's Disease

Synaptic density in the central nervous system can be measured in vivo using PET with [18F]SynVesT-1. While [18F]SynVesT-1 has been proven to be a powerful radiopharmaceutical for PET imaging of neurodegenerative disorders such as Parkinson's disease (PD), its currently validated acquisition and quantification protocols are invasive and technically challenging in these populations due to the arterial sampling and relatively long scanning times. The objectives of this work were to evaluate a noninvasive (reference tissue) quantification method for [18F]SynVesT-1 in PD patients and to determine the minimum scan time necessary for accurate quantification. [18F]SynVesT-1 PET scans were acquired in 5 patients with PD and 3 healthy control subjects for 120 min with arterial blood sampling. Quantification was performed using the one-tissue compartment model (1TCM) with arterial input function, as well as with the simplified reference tissue model (SRTM) to estimate binding potential (BPND) using centrum semiovale (CS) as a reference region. The SRTM2 method was used with k2′ fixed to either a sample average value (0.037 min−1) or a value estimated first through coupled fitting across regions for each participant. Direct SRTM estimation and the Logan reference region graphical method were also evaluated. There were no significant group differences in CS volume, radiotracer uptake, or efflux (ps > 0.47). Each fitting method produced BPND estimates in close agreement with those derived from the 1TCM (subject R2s > 0.98, bias < 10%), with no difference in bias between the control and PD groups. With SRTM2, BPND estimates from truncated scan data as short as 80 min produced values in excellent agreement with the data from the full 120 min scans (bias < 6%). While these are preliminary results from a small sample of patients with PD (n = 5), this work suggests that accurate synaptic density quantification may be performed without blood sampling and with scan time under 90 minutes. If further validated, these simplified procedures for [18F]SynVesT-1 PET quantification can facilitate its application as a clinical research imaging technology and allow for larger study samples and include a broader scope of patients including those with neurodegenerative diseases.
A proportional–integral-based robust state-feedback control method for linear parameter-varying systems and its application to aircraft

The integration of advanced linear parameter-varying and classical proportional–integral–derivative control methods has attracted great attention in control of nonlinear dynamic systems. However, linear parameter-varying proportional–integral–derivative control synthesis is a nonconvex bilinear matrix inequality problem. Although the synthesis conditions can be convexified in the case of proportional–integral control, a strong constraint on the structure of matrix variables usually leads to infeasible solutions. In this paper, a linear parameter-varying proportional–integral control design method is proposed to remove that constraint. The approach is based on the assumption of state-feedback proportional–integral control to guarantee the linear matrix inequality variables to be full matrices instead of block diagonal matrices, and extended linear matrix inequalities are proposed to synthesize the controller. This increases the likelihood of finding feasible linear matrix inequality solutions and reduces the conservatism. The proposed method is applied to control longitudinal and lateral dynamics of an F-16 aircraft and promising simulation results are obtained.
Thermo-hydro-mécanique des milieux poreux déformables avec double porosité et non-équilibre thermique local

Un modele constitutif completement couple est presente pour l'analyse rigoureuse de la deformation, de l'ecoulement de fluides et de transfert de chaleur dans les milieux poreux satures a double porosite soumis a des chargements thermo-hydro-mecaniques, y compris ceux induisant un non-equilibre thermique local. La phase solide contient deux cavites distinctes: le bloc poreux et le reseau des fissures. Les equations de champs sont obtenues a partir des equations de conservation de la masse, du mouvement et de l'energie et sont resolues par une approche par element finis. Le modele est utilise pour deux types d'applications: la stabilite d'un puits de forage stimulee thermiquement pour la recuperation de petrole et l'extraction de chaleur dans un reservoir geothermique fracture. Les differences substantielles, particulierement de la contrainte effective, soulignent l'influence majeure de la double porosite et du non-equilibre thermique pour predire le comportement des milieux fractures.
Satellite Radar Interferometry: Subsidence Monitoring Techniques

1 Introduction 2 Subsidence due to hydrocarbon production in the Netherlands 3 Persistent Scatterer InSAR 4 Quality control 5 Multi-track PSI 6 PSI subsidence monitoring in Groningen 7 Cross-validation and operational implementation 8 Discussion and future subsidence monitoring 9 Conclusions and recommendations Bibliography Appendices
TUM Data Innovation Lab

Graph learning has recently become more popular in the field of recommender systems, as many of the problems that recommender systems try to solve can be modeled as a graph. For fashion recommendations, we typically deal with very large and sparse data sets that make it especially challenging to build high-quality personalized recommender systems. Another challenge in fashion is fairness, as we usually deal with sensitive customer data. This project aims to implement a fashion recommender system using graph-based learning to provide personalized recommendations for customers with fairness evaluation. For this purpose, we explore the public data set from H&M, which contains article data (e. g. name, description), customer data (e. g. age, membership), and their transactions. To capture the complex relationships between customer, article, and their associated properties, we designed a graph database and implemented three graph-based recommender approaches: Random Walk as our baseline, a Graph Embedding, and a Graph Neural Network approach. We evaluated and compared these strategies in terms of how relevant and fair the recommendations are. Our results show that different approaches performed best for differing metrics and demonstrate the potential for graph-based recommender systems in the fashion domain.
Hybrid Wheat Seed Production in North Dakota

Wheat breeders with universities and commercial seed companies in the United States have been developing procedures and germ plasm for production of hybrid wheat. Research evaluating the merits of several alternative breeding procedures currently continues. Breeders were improving the agronomic milling and baking characteristics of parental lines, and were beginning to produce and evaluate hybrids to identify the superior hybrids. The economic success of hybrid wheat depends upon the yield advantage shown by hybrids over conventional wheat varieties, and the cost of planting hybrid seed as compared to present seed costs. Hybrid seed production is accomplished through the use of three wheat lines. Hybrid seed usually is obtained by planting the female and male parents in alternate drill strips. The article reviews a study conducted in hybridization.
Group Active Engagements for Facilitating Principles-Based Learning in Introductory Organismal Biology

ABSTRACT Organismal biology (OrgBio) comprises the diversity, structures, and functions of all organisms from bacteria to humans. Arguably, OrgBio is often the most poorly taught and least conceptually rigorous section of the introductory biology sequence offered at most U.S. institutions of higher education. This article reports on the successful implementation of conceptual and pedagogical reforms in an introductory OrgBio course offered at a large public university. Conceptual reforms were based on a theoretical framework consisting of universal physical and chemical laws, deep molecular homologies, and diverse structure–function relationships. Pedagogical reforms involved the development of group active engagements (GAEs) that were designed to encourage students to develop their abilities to engage in principles-based reasoning. A new model for characterizing different approaches toward principles-based reasoning in biology was developed to analyze these GAEs. Two surveys indicated that OrgBio students developed more favorable perceptions about the effectiveness of GAE-based course offerings, as compared to similar lecture-based versions.
Influence of the resistance to penetration and shearing on the gas consumption at the execution of the holes for planting saplings.

The present research displays the results obtained after the digging of holes for planting saplings in a previously unprepared soil, following the steps to carry them out according to some physical-mechanical properties of the soil. The research was carried out on a horizontal ground in the Forest District Iuliu Moldovan, in two forest compartments 31 C and 32 A, in a previously unprepared ground, on two types of soil: gley-soil (the muddy subtype) and alluvial soil (the vertical-gleyed subtype), and in Forest District Radna, forest compartment 74, on a brown typically luvic soil, using the Stihl BT 121 mottoborer with a 200 mm drill. The objectives of the research were to make a comparative determination, on different types of soil, of the qualitative parameters, among which the most important ones are: degree of loosening of the soil taken and left in the hole, resistance to penetration, resistance to shearing, degree of scattering of the soil taken out from the hole, degree of evacuation of the soil from the hole, gas consumption for the drilling of the hole, using the Stihl BT 121 mottoborer in order to establish its technical efficiency. In order to observe the influence which the drilling of holes has on its walls, we measured the resistance to penetration and resistance to shearing every 10 cm at a 30 cm depth, the proper depth for planting small-sized saplings, on two opposing sides, so that we could get the most probable values of these physical-mechanical properties of the soil. After taking the measures in order to establish the compaction degree of the wall and of the bottom of the hole by the borer in that interval, it was judged that in conditions of normal humidity, if the borers have sharp knives and are well conceived and executed from a technical point of view, there are no big values of the resistance to penetration which could affect the subsequent development of the saplings. The usefulness of the present paper stays in the research data collected, processed, analyzed and valorized in order to offer a pertinent study material, which could indeed be used by specialists in designing the process for obtaining, through a mechanized means, the holes for planting small-sized saplings on a horizontal ground, using the Stihl BT 121 motto-borer.
Dimeric G-quadruplex motifs determine a large fraction of strong replication origins in vertebrates

Replication of vertebrate genomes is tightly regulated to ensure accurate duplication, but our understanding of the interplay between genetic and epigenetic factors in this regulation remains incomplete. Here, we investigated the involvement of three elements enriched at gene promoters and replication origins: guanine-rich motifs potentially forming G-quadruplexes (pG4s), nucleosome-free regions (NFRs), and the histone variant H2A.Z, in the firing of origins of replication. We show that two pG4s on the same DNA strand (dimeric pG4s) are sufficient to induce assembly of an efficient minimal replication origin without inducing transcription, and that dimeric pG4s in replication origins are located in an NFR next to well-positioned nucleosomes enriched in H2A.Z. Thus, our data suggest a crucial role for dimeric pG4s in the organization and duplication of vertebrate genomes.
Mathematics Education: Models and Processes

Contents: Preface. Cognitive Psychology and Mathematics Education. Cognition and Cognitive Development. Cognitive Models and Processes in Mathematics Education. Numerical Models and Processes. Elementary Computational Models and Processes: Addition and Subtraction. Elementary Computational Models and Processes: Multiplication and Division. Advanced Computational Models and Processes. Problem Solving, Problem Posing, and Mathematical Thinking. Reflections and Recommendations.
Effect on Chaohu Lake water environment of water transfer from Yangtze River to Chaohu Lake.

A one-dimensional water quality model DYRESM-CAEDYM for Chaohu Lake was established,and the parameters of the model were calibrated by monitoring data including water quality,hydrology and meteorology in 2005.Then,the parameters of a water quality model applicable to the water environment of Chaohu Lake were determined.The model was applied to simulate the influence of water transfer from the Yangtze River to Chaohu Lake on TN,TP,and chlorophyll a mass concentrations in Chaohu Lake.The simulated results show that the water transfer project could decrease the concentrations of TN and TP by 16% and 19% when the annual volume of water regulation is 9.57 billion m~3.The water transfer project could also reduce the outbreak intensity of algal blooms;the mass concentration peaks of chlorophyll a could decline from 51.42(μg/L) to 38.96(μg/L),and the number of days in which the mass concentration of chlorophyll a exceeded 30(μg/L) could be reduced from 26 d to 16 d.The effect of pollution control in the drainage area was analyzed.The results show that TN and TP could decrease by 24.9% and 33.3%; the mass concentration peaks of chlorophyll a in summer could decline from 51.42 (μg/L) to 32.72(μg/L);and the number of days in which the mass concentration of chlorophyll a exceeded 30(μg/L) could be reduced from 26 d to 7 d,as compared with the case without pollution control if the inlet pollution load of tributaries were reduced by 5% and sediment dredging was carried out.
Design and Implementation of a Wilkinson Power Divider with Integrated Band Stop Filters Based on Parallel-coupled Lines

This paper presents a technique to improve the spurious suppression performance at the second harmonic (2f0) of a Wilkinson power divider. The technique is achieved by the insertion of bandstop filters realizing with parallel-coupled lines with the characteristic impedance of 2√Z0Ω and the electrical length of λ/8 in a conventional structure. The simulated and measured results of the conventional and the proposed divider are compared at 0.9 GHz. The insertion losses (S21, S31) are less than 3.1 dB, while the return losses (S11) are less than 34.6 dB across 100% fractional bandwidth. Moreover, the proposed Wilkinson power divider achieves more than 25.5 dB suppression at 2f0.
PSYCHOLOGICAL WELL-BEING AND ORGANISATIONAL COMMITMENT: A RELATIONSHIP AMONG SOCIO-DEMOGRAPHIC VARIABLES

The current study investigates psychological well-being and organisational Commitment among service sector employees. Psychological well-being means living life in such a satisfying way that it leads to the development and self-realisation of an individual (Ryff & Keyes, 1995). Organisational Commitment means the employee’s attachment to their organisation. Using a standard questionnaire, the variables of psychological well-being and organisational well-being were both measured. There is evidence from earlier studies that psychological well-being impacts organisational commitment among employees. The results of the study were found using SPSS software. The present study deals with the employee’s psychological well-being and organisational commitment in relation to their gender, age, marital status, and academic qualification.
Some Beneficial Effects of Coenzyme Q10 Supplementation on Patients with Chronic Obstructive Pulmonary Disease

10.30699/jambs.31. 146.238 Background & Objective: Chronic inflammation, dyspnea and activity limitation are common phenomena in patients with chronic obstructive lung disease. Clinical studies suggest that Ubiquinone has anti-inflammatory and energetic properties. Here the beneficial effect of CoQ10 in patients with COPD will be studied. Materials & Methods: Baesd on the census method, 90 patients with moderate to severe COPD were divided into two identical placebo and CoQ10 groups. High sensitive-C-reactive protein (hs-CRP), Forced Expiratory Volume in 1 second, numerical rating breathlessness scale and "the time to get exhausted" were evaluated and recorded at baseline and the end of the study. The CoQ10 group received 120 mg of CoQ10 supplement per day versus the placebo group who also received a placebo (identical in look, size and taste to pharmaceutical sample) and were followed for 6 weeks. Data were analyzed using t-test, and nonparametric statistical tests. Qualitative variables were assessed by chi-square or Fisher exact tests. Results: The study included 49(53.6%) women and 41(46.4%) men, collectively 90 patients with moderate to severe COPD. The mean age was 66.97±12.59 years in the placebo and 64.21±11.78 years in the CoQ10 group (p=0.30). Breathlessness scale was improved in CoQ10 group (p<0.001). hs-CRP significantly declined after intervention in the CoQ10 compared to the placebo group (p<0.001). No serious side effects were observed as a result of CoQ10 consumption. Conclusion: Daily administration of CoQ10 in COPD patients increases hs-CRP and improves dyspnea and "the time to get exhausted” without side effect.
How consistent are non-native speakers in their usage of filler particles when talking to native speakers?

This paper investigates the intra-individual consistency in the production of filler particle frequencies and forms. The data consist of five non-native (L2) mid to high proficient speakers of German with English as first language. Each L2 speaker converses with five different German native (L1) speakers in task-based dialogues. The results show that the L2 speakers are rather consistent in the use of FP frequencies and forms across the five dialogues, with no obvious alignment for static measures such as mean FP frequency or the proportion of vocalic-nasal and nasal FP forms. When tracing their relative FP frequencies over the course of the dialogue, some L2 speakers show convergence to L1, while others remain persistent. The data thus partly undergird the speaker-specificity of filler particles. It remains open whether observed convergence between L1 and L2 speakers in this data is due to alignment or happening coincidentally.
N ° 2009-06 Product complexity , quality of institutions and the pro-trade effect of immigrants

The paper assesses the trade-creating impact of foreign-born residents on the international imports and exports of the French regions where they are settled. The pro-trade effect of immigrants is investigated along two intertwined dimensions: the complexity of traded goods and the quality of institutions in partner countries. The trade-enhancing impact of immigrants is, on average, more salient when they come from a country with weak institutions. However, this positive impact is especially large on the imports of simple products. When we turn to complex goods, for which the information channel conveyed by immigrants is the most valuable, immigration enhances imports regardless of the quality of institutions in the partner country. Regarding exports, immigrants substitute for weak institutions on both simple and complex goods. JEL classification: F14, F22, R12.
Performance Study of Intercalated Meltblown Nonwoven Materials Based on Gaussian Process Regression

: The demand for face masks is on the rise due to the COVID-19 pandemic. Melt-blown nonwoven material is an important raw material for mask production, and its structural variables determine the performance of the final product. In this paper, the prediction model between structural variables and product performance is established, and the relationship between structural variables and product performance is obtained by using Gaussian process regression method, and the prediction model is tested to further verify the reliability of the model. The experimental results show that. The prediction accuracy of the model based on Gaussian process regression is high, and the average absolute error is less than 0.2, so the prediction method is effective. The final experimental results have a certain degree of reference significance for the study of the influence of the structure variables of intercalated melt-blown nonwovens on the product properties, which is helpful to provide a certain theoretical basis for the establishment of the control mechanism of product properties.
NANOSTRUCTURED LIPID CARRIERS ACTING ON CENTRAL NERVOUS SYSTEM

: The central nervous system, or CNS for short, is among the most significant bodily organs because of what it does for the human body. Therefore, a decline in its function may lead to a variety of maladies of the CNS or other body systems that are highly significant. Drug delivery technologies based on lipids called nanostructured lipid carriers (NLCs) have received much study. The creation of NLCs, or nanostructured lipid carriers, was done. The diverse delivery methods for nano-based systems include parenteral, transdermal, ophthalmic, oral, and topical. The creation of NLCs included blending spatially incompatible liquid and solid lipids. Improved bioavailability and higher solubility are drug therapy's key benefits over traditional carriers of NLCs. NLCs used for brain targeting NLCs for CNS diseases (glioma/brain cancer, ischemic stroke, Alzheimer's disease, Parkinson's disease, epilepsy, migraine, Hodgkin's disease, schizophrenia, and multiple sclerosis) are discussed in this review along with their benefits and drawbacks. NLCs method, the most common categories include imperfect, amorphous, and multiple types. Solid lipids, liquid lipids, surfactants, and other excipients are also employed in NLCs. The methods used to create NLCs include high-pressure homogenization, solvent emulsification/evaporation, micro-emulsification, ultrasonication, supercritical fluid, and solvent injection. In recent years, it has drawn more and more interest