Miracle-dz/UniFAR-FTUs huggingface dataset:
Hypertension and acute myocardial infarction: an overview.

History of hypertension is a frequent finding in patients with acute myocardial infarction (AMI) and its recurring association with female sex, diabetes, older age, less frequent smoking and more frequent vascular comorbidities composes a risk profile quite distinctive from the normotensive ischemic counterpart.Antecedent hypertension associates with higher rates of death and morbid events both during the early and long-term course of AMI, particularly if complicated by left ventricular dysfunction and/or congestive heart failure. Renin-angiotensin-aldosterone system blockade, through either angiotensin-converting enzyme inhibition, angiotensin II receptor blockade or aldosterone antagonism, exerts particular benefits in that high-risk hypertensive subgroup.In contrast to the negative implications carried by antecedent hypertension, higher systolic pressure at the onset of chest pain associates with lower mortality within 1 year from coronary occlusion, whereas increased blood pressure recorded after hemodynamic stabilization from the acute ischemic event bears inconsistent relationships with recurring coronary events in the long-term follow-up.Whether antihypertensive treatment in post-AMI hypertensive patients prevents ischemic relapses is uncertain. As a matter of fact, excessive diastolic pressure drops may jeopardize coronary perfusion and predispose to new acute coronary events, although the precise cause-effect mechanisms underlying this phenomenon need further evaluation.
Depth discrimination of constant angular size stimuli in action space: role of accommodation and convergence cues

In our daily life experience, the angular size of an object correlates with its distance from the observer, provided that the physical size of the object remains constant. In this work, we investigated depth perception in action space (i.e., beyond the arm reach), while keeping the angular size of the target object constant. This was achieved by increasing the physical size of the target object as its distance to the observer increased. To the best of our knowledge, this is the first time that a similar protocol has been tested in action space, for distances to the observer ranging from 1.4–2.4 m. We replicated the task in virtual and real environments and we found that the performance was significantly different between the two environments. In the real environment, all participants perceived the depth of the target object precisely. Whereas, in virtual reality (VR) the responses were significantly less precise, although, still above chance level in 16 of the 20 observers. The difference in the discriminability of the stimuli was likely due to different contributions of the convergence and the accommodation cues in the two environments. The values of Weber fractions estimated in our study were compared to those reported in previous studies in peripersonal and action space.
Towards the Reproducibility of Using DLS Techniques in Scientific Applications

Reproducibility of the execution of scientific applications on parallel and distributed systems is a growing interest, underlying the trustworthiness of the experiments and the conclusions derived from experiments. Dynamic loop scheduling (DLS) techniques are an effective approach towards performance improvement of scientific applications via load balancing. These techniques address algorithmic and systemic sources of load imbalance by dynamically assigning tasks to processing elements. The DLS techniques have demonstrated their effectiveness when applied in real applications. Complementing native experiments, simulation is a powerful tool for studying the behavior of parallel and distributed applications. This work is a comprehensive reproducibility study of experiments using DLS techniques published in earlier literature to verify their implementations into SimGrid-MSG. In earlier work, it was shown that having a detailed degree of information regarding the experiments to be reproduced is essential for a successful reproduction. This work concentrates on the reproduction of experiments with variable application behaviour and high degree of parallelism of applications and systems. It is shown that reproducing measurements of applications with high variance in task execution times is challenging, albeit feasible and useful. The success of the present reproducibility study signifies the fact that the implementation of the DLS techniques in SimGrid-MSG is verified for the considered applications and systems. Thus, it enables well-founded future research using the DLS techniques in simulation.
A Study of Factors Affecting on Customers Purchase Intention Case Study : the Agencies of Bono Brand Tile in Tehran

This study aimed to investigate the factors affecting on the purchase intention of Bono brand tile customers. In this study, a researcher-made questionnaire with 25 questions was used. The statistical population included the customers of Bono brand tile, through which 384 people were selected random sampling to respond research questionnaire. To assess questionnaire validity, content validity and construct validity were used and its reliability was measured through Cronbach's alpha as 0.936. Data resulted from research questionnaire, were analyzed by the use of confirmatory factor analysis and multiple regression analysis. Therefore, based on the results of this study, the variables of product quality, and brand advertising and name had the highest impact on customers' purchase intention, but the two variables of packaging and price didn’t have a significant impact on customers' purchase intention. Keywords— product quality, advertising, brand name, packaging, price, purchase intention, Bono
Self-ligating Brackets: Where are we now?

The current situation regarding self-ligating brackets is reviewed. Recent developments, clinical advantages, and remaining imperfections are described. The question of active versus passive ligation is scrutinized. The evidence regarding treatment efficiency is reviewed. Suggested clinical tips and changes of treatment mechanics are summarized and illustrated. Self-ligating brackets have reached a stage of design and production control, where the advantages are significantly greater than the remaining imperfections.
Le tournant cognitif en économie de la décision et des comportements

Parler d'un tournant cognitif de la theorie economique de la decision suppose que celle-ci s'est mise, a un moment donne, a prendre davantage et mieux en compte les processus mentaux – voire neuronaux – qui president au traitement de l'information pertinente pour la prise de decision et qui accompagnent, determinent et expliquent la prise de decision. Cette prise en compte suppose, bien entendu, la modification des modeles de decision, mais sans doute egalement un changement dans la demarche ui preside a la modelisation, moins tributaire de l'approche instrumentale inspiree de l'irrealisme methodologique de Milton Friedman (1953) d'apres laquelle le caractere realiste des hypotheses d'un modele importe peu du moment qu'il predit correctement les comportements, et plus preoccupee d'une description fidele des processus mentaux effectifs qui conduisent aux decisions. La tâche qui nous attend est donc double. Il s'agit d'abord de reperer chronologiquement un eventuel tournant. Il s'agit ensuite de caracteriser l'avant et l'apres. Il est assez facile de reperer les elements d'un tournant cognitif en theorie economique de la decision dans au moins deux domaines : la theorie de la decision dans l'incertain, ou les consequences de l'action choisie au terme du processus de decision dependent de la realisation de certains evenements, et la theorie de la decision comportant une dimension temporelle. Nous nous concentrerons ici sur l'analyse du tournant cognitif dans le premier domaine.
Neural Markers of Inhibition in Human Memory Retrieval

Retrieving particular information from memory facilitates the later retrieval of that information, but also impairs the later retrieval of related, interfering information. It has been theorized that this retrieval-induced forgetting reflects inhibition of interfering memory representations. We used event-related fMRI to investigate the functional neuroanatomy of this impaired retrieval, at the time the impairment is observed. Neural activity differences between impaired and facilitated information occurred in left ventrolateral prefrontal cortex (VLPFC, BA 45 and 47), precuneus (BA 7), and right inferior parietal lobule (IPL, BA 40). Activity in left anterior VLPFC (BA 47) and left posterior temporal cortex (BA 22), regions implicated in the controlled retrieval of weak semantic memory representations, predicted the degree of retrieval-induced forgetting. In contrast, activity in precuneus and right IPL predicted the degree of retrieval-induced facilitation. Our findings demonstrate that impairment of interfering memories and facilitation of practiced memories involve distinct neural processes, and suggest that the impairment reflects inhibition that weakens interfering memory representations.
A morphometric study of mucins and small airway plugging in cystic fibrosis

Rationale: Little knowledge exists on structural changes and plugging in small airways in cystic fibrosis. Objective: To characterise the extent of plugging and contribution of secreted mucins to the plugs. Methods: Small airways in patients with cystic fibrosis at transplantation (n = 18) were compared with control non-smokers (n = 10). Tissue sections were stained with Alcian blue (AB)/periodic acid-Schiff (PAS), for mucins MUC5B and MUC5AC, and for neutrophils and its chemoattractant interleukin (IL) 8. Epidermal growth factor receptor (EGFR) and its ligand pro-transforming growth factor α were also identified using immunohistochemical staining. Epithelial and luminal contents were assessed morphometrically. Results: Plugs occupying >50% of total luminal volume were found in 147 of 231 (63.6%) airways in patients with cystic fibrosis, but only in 1 of 39 (2.6%) airways in controls. In the epithelium of patients with cystic fibrosis, AB/PAS, MUC5B, and MUC5AC-stained volume densities were increased 10-fold (p<0.01), indicating increased mucin production. In airway lumens, staining for mucins was also increased in cystic fibrosis, indicating increased mucin secretion. In the epithelium of patients with cystic fibrosis, neutrophil numbers were markedly increased and were inversely correlated with volume densities of mucous glycoconjugates (r = −0.66, p<0.005). IL8 staining was increased in the epithelium of patients with cystic fibrosis and colocalised with mucins. Staining for EGFR and for pro-transforming growth factor α were increased in the epithelium of patients with cystic fibrosis; positive correlations were found between EGFR-stained volume density and both AB/PAS and IL8-stained volume densities. Conclusions: Most of the small airways are plugged in cystic fibrosis at the time of transplantation. Mucins contribute to airway plugging. Recruited neutrophils may be involved in mucin secretion in the plugs. Increased expression of EGFR and its ligand suggests roles in mucin synthesis and neutrophil recruitment.
A Common Currency System for Spontaneous Transactions on Public Networks-Is it feasible ?

The aim of this paper is to examine indications for a common currency system on the Internet for spontaneous transactions. First the framework for such a currency system and the theoretical background on common currencies are discussed. Examples of common currencies already in use are evaluated according to a set of criteria developed by the authors. Furthermore the theoretical ideas and the insights gained by the evaluation of these currency systems are synthesized to answer the question in the title. The paper ends with an outlook into the future. Röckelein, Maier A common currency system for spontaneous transactions on public networks 2
Vortex ring based display

In this paper, we propose a new kind of mid-air projection display based on vortex ring. These days, there have been many studies and developments on mid-air displays that can display quite realistic floating holographic images in the real world. However, most of the conventional mid-air displays can only show their holographic images within a 2D plane and thus users can only enjoy very limited 3D sensation. Our proposed vortex ring display utilizes the great transportability of vortex ring to make a flying fog screen. We have found the proposed vortex ring display can break through the conventional limitation of 3D sensation and demonstrate more realistic physical effects together.
National Breast Cancer Audit: overview of invasive breast cancer in New Zealand.

INTRODUCTION The National Breast Cancer Audit collects data on the care of early breast cancer patients in Australia and New Zealand. An overview of invasive breast cancer in New Zealand is presented with emphasis on comparing the screened population with symptomatic referrals. METHODS All New Zealand data in the National Breast Cancer Audit with a diagnosis date of 2008 have been included in the report. Data was analysed with an aim to compare the presenting features and management of screen detected invasive cancer with symptomatic referrals in New Zealand. RESULTS There were 2371 cases of breast cancer, 52% of which were symptomatic referrals, 37% of which were BreastScreen Aotearoa referrals. Higher breast conservation rates were reported in the screening population. 3% of patients had involved margins after surgery. Almost two-thirds (62%) of BreastScreen patients underwent a sentinel node biopsy without further axillary surgery. 72% of screening patients and 86% of symptomatic patients who were high risk did not receive post mastectomy radiotherapy. A larger proportion of symptomatic patients received chemotherapy. Endocrine therapy was prescribed to 81% of hormone receptor positive patients. CONCLUSION Patients with early invasive breast cancer in New Zealand were managed appropriately according to audit performance indicators and clinical guidelines. The numbers of high risk patients not receiving post mastectomy radiotherapy and the lack of endocrine treatment in some patients with hormone receptor positive tumours may warrant further investigation.
Feedback control in active sensing: rat exploratory whisking is modulated by environmental contact

Rats sweep their facial whiskers back and forth to generate tactile sensory information through contact with environmental structure. The neural processes operating on the signals arising from these whisker contacts are widely studied as a model of sensing in general, even though detailed knowledge of the natural circumstances under which such signals are generated is lacking. We used digital video tracking and wireless recording of mystacial electromyogram signals to assess the effects of whisker–object contact on whisking in freely moving animals exploring simple environments. Our results show that contact leads to reduced protraction (forward whisker motion) on the side of the animal ipsilateral to an obstruction and increased protraction on the contralateral side. Reduced ipsilateral protraction occurs rapidly and in the same whisk cycle as the initial contact. We conclude that whisker movements are actively controlled so as to increase the likelihood of environmental contacts while constraining such interactions to involve a gentle touch. That whisking pattern generation is under strong feedback control has important implications for understanding the nature of the signals reaching upstream neural processes.
Ankyrin regulates KATP channel membrane trafficking and gating in excitable cells

KATP channels play critical roles in many cellular functions by coupling cell metabolic status to electrical activity. First discovered in cardiomyocytes 1, KATP channels (comprised of Kir6.x and SUR subunits) have since been found in many other tissues, including pancreatic beta cells, skeletal muscle, smooth muscle, brain, pituitary, and kidney. By linking cellular metabolic state with membrane potential, KATP channels are able to regulate a number of cellular functions such as hormone secretion, vascular tone, and excitability. Specifically, a reduction in metabolism causes a decrease in the ATP:ADP ratio, opening of KATP channels and allowing K+ efflux, membrane hyperpolarization, and suppression of electrical activity. Conversely, increased cellular metabolism causes a decrease in the ATP:ADP ratio that leads to closure of the KATP channel, membrane depolarization, and stimulation of cell electrical activity.
Changing a Single Amino Acid Residue Switches Processive and Non-processive Behavior of Aspergillus nigerEndopolygalacturonase I and II*

Processivity, also known as multiple attack on a single chain, is a feature commonly encountered only in enzymes in which the substrate binds in a tunnel. However, of the sevenAspergillus niger endopolygalacturonases, which have an open substrate binding cleft, four enzymes show processive behavior, whereas the other endopolygalacturonases are randomly acting enzymes. In a previous study (Benen, J.A.E., Kester, H.C.M., and Visser, J. (1999) Eur. J. Biochem. 259, 577–585) we proposed that the high affinity for the substrate of subsite −5 of processive endopolygalacturonase I constitutes the origin of the multiple attack behavior. Based on primary sequence alignments of A. nigerendopolygalacturonases and three-dimensional structure analysis of endopolygalacturonase II, an arginine residue was identified in the processive enzymes at a position commensurate with subsite −5, whereas a serine residue was present at this position in the non-processive enzymes. In endopolygalacturonase I mutation R95S was introduced, and in endopolygalacturonase II mutation S91R was introduced. Product progression analysis on polymer substrate and bond cleavage frequency studies using oligogalacturonides of defined chain length for the mutant enzymes revealed that processive/non-processive behavior is indeed interchangeable by one single amino acid substitution at subsite −5, Arg→Ser or Ser→Arg.
The criterion of Kolmogorov-Smirnov for binary decision tree: Application to interval valued variables

With the information technology development, data sets often contain a very large number of observations. Symbolic data analysis treats new units that are underlying concepts on the given data base or found by clustering. In this way, it is possible to reduce the size of the data set to be processed by transforming the initial classical variables into variables called symbolic variables. In symbolic data analysis, the values of the variables can be, among others, intervals. The algebraic structure of these variables leads us to adapt criteria to be able to study them. In this paper, we propose the extension of the Kolmogorov-Smirnov's binary splitting criterion to interval data. This criterion is used as a test selection metric for decision tree induction. For this criterion, the values taken by the explanatory variables have to be ordered. We have been interested in different possible orders of these interval values. We present some results using the pure assignment in order to examine the quality and the precision of this criterion. We compare this criterion to some classical criteria (Gini and entropy) in the case of pure assignment. An application in the case where the variable to be explained is a correlation is presented. We end this paper with a probabilistic method of assignment using the criterion of Komogorov-Smirnov.
Transition of graduates of the Master of Occupational Therapy to practice.

BACKGROUND/AIM The transition from classroom to clinical practice is a necessary and challenging journey for occupational therapy students. In recent years, worldwide trends in occupational therapy education are moving towards graduate-entry in professional preparation courses. Little is known about the journey experienced by these graduates when they enter practice. This qualitative study aimed to explore the lived experience of these graduates in their transition from student to practitioner within first six months of practice. METHODS A phenomenological approach was adopted for this study. Using purposive sampling, eight participants from a recent graduate cohort of the Master of Occupational Therapy from the University of Sydney were recruited. Data was collected via in-depth, face-to-face interviews. The focus of inquiry was on the experience of transition. Interviews were audio-taped, transcribed and analysed thematically. Member checking and consensus coding were conducted to increase trustworthiness of the study. RESULTS Four themes emerged from the interview data. The themes were (i) valuing maturity; (ii) being new; (iii) needing skills; and (iv) pursuing satisfaction. Participants described metaphors about their experience across and within these themes. CONCLUSIONS Recognising the experience of transition from student to practitioner has the potential to assist university staff in the development of the educational curriculum. Understanding this transition can also help employers and therapists in providing adequate support and supervision for new graduates. Furthermore, awareness of the transition experience allows students to better prepare themselves for their own transition to practice.
Implementing Secure Laptop-Based Testing in an Undergraduate Nursing Program: A Case Study

This article presents the implementation of secure laptop-based testing in an undergraduate nursing program. Details on how to design, develop, implement, and secure tests are discussed. Laptop-based testing mode is also compared with the computer-laboratory–based testing model. Five elements of the laptop-based testing model are illustrated: (1) it simulates the national board examination, (2) security is achievable, (3) it is convenient for both instructors and students, (4) it provides students hands-on practice, (5) continuous technical support is the key.
The Future of Networked Privacy: Challenges and Opportunities

Building on recent work in privacy management and disclosure in networked spaces, this two-day workshop examines networked privacy challenges from a broader perspective by (1) identifying the most important issues researchers will need to address in the next decade and (2) working to create actionable solutions for these privacy issues. This workshop comes at a critical time for organizations, researchers, and consumers, as content-sharing applications soar in popularity and more privacy and security vulnerabilities emerge. Workshop participants and organizers will work together to develop a guiding framework for the community that highlights the future challenges and opportunities of networked privacy.
Optimal Monetary and Fiscal Policy: A Linear-Quadratic Approach

We propose an integrated treatment of the problems of optimal monetary and fiscal policy for an economy in which prices are sticky (so that the supply-side effects of tax changes are more complex than in standard fiscal analyses) and the only available sources of government revenue are distorting taxes (so that the fiscal consequences of monetary policy must be considered alongside the usual stabilization objectives). Our linear-quadratic approach allows us to nest both conventional analyses of optimal monetary stabilization policy and analyses of optimal tax-smoothing as special cases of our more general framework. We show how a linear-quadratic policy problem can be derived which yields a correct linear approximation to the optimal policy rules from the point of view of the maximization of expected discounted utility in a dynamic stochastic general-equilibrium model. Finally, in addition to characterizing the optimal dynamic responses to shocks under an optimal policy, we derive policy rules through which the monetary and fiscal authorities may implement the optimal equilibrium. These rules take the form of optimal targeting rules, specifying an appropriate target criterion for each authority.