Miracle-dz/UniFAR-FTUs huggingface dataset:
Subregion‐specific role of glutamate receptors in the nucleus accumbens on drug context‐induced reinstatement of cocaine‐seeking behavior in rats

The functional integrity of the nucleus accumbens (NAC) core and shell is necessary for contextual cocaine‐seeking behavior in the reinstatement animal model of drug relapse; however, the neuropharmacological mechanisms underlying this phenomenon are poorly understood. The present study evaluated the contribution of metabotropic glutamate receptor subtype 1 (mGluR1) and α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA)/kainate receptor populations to drug context‐induced reinstatement of cocaine‐seeking behavior. Rats were trained to lever press for un‐signaled cocaine infusions in a distinct context followed by extinction training in a different context. Cocaine‐seeking behavior (non‐reinforced active lever pressing) was then assessed in the previously cocaine‐paired and extinction contexts after JNJ16259685 (mGluR1 antagonist: 0.0, 0.6, or 30 pg/0.3 µl/hemisphere) or CNQX (AMPA/kainate receptor antagonist: 0.0, 0.03, or 0.3 µg/0.3 µl /hemisphere) administration into the NAC core, medial or lateral NAC shell, or the ventral caudate‐putamen (vCPu, anatomical control). JNJ16259685 or CNQX in the NAC core dose‐dependently impaired contextual cocaine‐seeking behavior relative to vehicle. Conversely, CNQX, but not JNJ16259685, in the lateral or medial NAC shell attenuated, whereas CNQX or JNJ16259685 in vCPu failed to inhibit, this behavior. The manipulations failed to alter instrumental behavior in the extinction context, general motor activity or food‐reinforced instrumental behavior in control experiments. Thus, glutamate‐mediated changes in drug context‐induced motivation for cocaine involve distinct neuropharmacological mechanisms within the core and shell subregions of the NAC, with the stimulation of mGlu1 and AMPA/kainate receptors in the NAC core and the stimulation of AMPA/kainate, but not mGlu1, receptors in the NAC shell being necessary for this phenomenon.
Generation and Analysis of Strategies in an Evolutionary Social Learning Game

Title of dissertation: GENERATION AND ANALYSIS OF STRATEGIES IN AN EVOLUTIONARY SOCIAL LEARNING GAME James Ryan Carr, Doctor of Philosophy, 2013 Dissertation directed by: Professor Dana Nau Department of Computer Science An important way to learn new actions and behaviors is by observing others, and several evolutionary games have been developed to investigate what learning strategies work best and how they might have evolved. In this dissertation I present an extensive set of mathematical and simulation results for Cultaptation, which is one of the best-known such games. I derive a formula for measuring a strategy’s expected reproductive success, and provide algorithms to compute near-best-response strategies and near-Nash equilibria. Some of these algorithms are too complex to run quickly on larger versions of Cultaptation, so I also show how they can be approximated to be able to handle larger games, while still exhibiting better performance than the current best-known Cultaptation strategy for such games. Experimental studies provide strong evidence for the following hypotheses: 1. The best strategies for Cultaptation and similar games are likely to be conditional ones in which the choice of action at each round is conditioned on the agent’s accumulated experience. Such strategies (or close approximations of them) can be computed by doing a lookahead search that predicts how each possible choice of action at the current round is likely to affect future performance. 2. Such strategies are likely to prefer social learning most of the time, but will have ways of quickly detecting structural shocks, so that they can switch quickly to individual learning in order to learn how to respond to such shocks. This conflicts with the conventional wisdom that successful social-learning strategies are characterized by a high frequency of individual learning; and agrees with recent experiments by others on human subjects that also challenge the conventional wisdom. GENERATION AND ANALYSIS OF STRATEGIES IN AN EVOLUTIONARY SOCIAL LEARNING GAME
A Study of Lagrangean Decompositions and Dual Ascent Solvers for Graph Matching

We study the quadratic assignment problem, in computer vision also known as graph matching. Two leading solvers for this problem optimize the Lagrange decomposition duals with sub-gradient and dual ascent (also known as message passing) updates. We explore this direction further and propose several additional Lagrangean relaxations of the graph matching problem along with corresponding algorithms, which are all based on a common dual ascent framework. Our extensive empirical evaluation gives several theoretical insights and suggests a new state-of-the-art anytime solver for the considered problem. Our improvement over state-of-the-art is particularly visible on a new dataset with large-scale sparse problem instances containing more than 500 graph nodes each.
Association of microtubule-associated protein 2 (MAP 2) with microtubules and intermediate filaments in cultured brain cells

The classification of MAP 2 as a microtubule-associated protein is based on its affinity for microtubules in vitro and its filamentous distribution in cultured cells. We sought to determine whether MAP 2 is also able to bind in situ to organelles other than microtubules. For this purpose, primary cultures of rat brain cells were stained for immunofluorescence microscopy with a rabbit anti-MAP 2 antibody prepared in our laboratory, as well as with antibodies to vimentin, an intermediate filament protein, and to tubulin, the major subunit of microtubules. MAP 2 was present on cytoplasmic fibers in neurons and in a subpopulation of the flat cells present in the cultures. Our observations were concentrated on the flat cells because of their suitability for high-resolution immunofluorescence microscopy. Double antibody staining revealed co-localization of MAP 2 with both tubulin and vimentin in the flat cells. Pretreatment of the cultures with vinblastine resulted in the redistribution of MAP 2 into perinuclear cables that contained vimentin. Tubulin paracrystals were not stained by anti-MAP 2. In cells extracted with digitonin, the normal fibrillar distribution of MAP 2 was resistant to several treatments (PIPES buffer plus 10 mM Ca++, phosphate buffer at pH 7 or 9) that induced depolymerization of microtubules, but not intermediate filaments. Staining of the primary brain cells was not observed with preimmune serum nor with immune serum adsorbed prior to use with pure MAP 2. We detected MAP 2 on intermediate filaments not only with anti-MAP 2 serum, but also with affinity purified anti-MAP 2 and with a monoclonal anti-MAP 2 prepared in another laboratory. We conclude from these experiments that material recognized by anti-MAP 2 antibodies associates with both microtubules and intermediate filaments. We propose that one function of MAP 2 is to cross-link the two types of cellular filaments.
Forward Guidance and the State of the Economy

This paper examines the economic effects of forward guidance using a New Keynesian model with a zero lower bound (ZLB) constraint on the short-term nominal interest rate. Forward guidance is modeled with anticipated news shocks to the monetary policy rule. There are five key findings: (1) the stimulative effect of forward guidance falls as the economy deteriorates or as households expect a slower recovery because there is a smaller margin to lower expected policy rates; (2) longer forward guidance horizons do not generate increasingly larger impact effects on output when the total amount of news is fixed, unlike with an exogenous interest rate peg; (3) in steady state, an unanticipated shock has a larger impact effect on output than a news shock, but a news shock has a larger cumulative effect in every state of the economy; (4) at the ZLB, the cumulative effect on output from lengthening the forward guidance horizon increases over short horizons but decreases thereafter, which indicates the central bank faces limits on how far forward guidance can extend into the future and continue to add stimulus; and (5) forward guidance is stimulative in the absence of other shocks, but the observed effect on output is smaller or even negative if another shock simultaneously reduces demand.
A subset of yeast vacuolar protein sorting mutants is blocked in one branch of the exocytic pathway

Exocytic vesicles that accumulate in a temperature-sensitive sec6 mutant at a restrictive temperature can be separated into at least two populations with different buoyant densities and unique cargo molecules. Using a sec6 mutant background to isolate vesicles, we have found that vacuolar protein sorting mutants that block an endosome-mediated route to the vacuole, including vps1, pep12, vps4, and a temperature-sensitive clathrin mutant, missort cargo normally transported by dense exocytic vesicles, such as invertase, into light exocytic vesicles, whereas transport of cargo specific to the light exocytic vesicles appears unaffected. Immunoisolation experiments confirm that missorting, rather than a changed property of the normally dense vesicles, is responsible for the altered density gradient fractionation profile. The vps41Δ and apl6Δ mutants, which block transport of only the subset of vacuolar proteins that bypasses endosomes, sort exocytic cargo normally. Furthermore, a vps10Δ sec6 mutant, which lacks the sorting receptor for carboxypeptidase Y (CPY), accumulates both invertase and CPY in dense vesicles. These results suggest that at least one branch of the yeast exocytic pathway transits through endosomes before reaching the cell surface. Consistent with this possibility, we show that immunoisolated clathrin-coated vesicles contain invertase.
Damage to ventral and dorsal language pathways in acute aphasia

Converging evidence from neuroimaging studies and computational modelling suggests an organization of language in a dual dorsal–ventral brain network: a dorsal stream connects temporoparietal with frontal premotor regions through the superior longitudinal and arcuate fasciculus and integrates sensorimotor processing, e.g. in repetition of speech. A ventral stream connects temporal and prefrontal regions via the extreme capsule and mediates meaning, e.g. in auditory comprehension. The aim of our study was to test, in a large sample of 100 aphasic stroke patients, how well acute impairments of repetition and comprehension correlate with lesions of either the dorsal or ventral stream. We combined voxelwise lesion-behaviour mapping with the dorsal and ventral white matter fibre tracts determined by probabilistic fibre tracking in our previous study in healthy subjects. We found that repetition impairments were mainly associated with lesions located in the posterior temporoparietal region with a statistical lesion maximum in the periventricular white matter in projection of the dorsal superior longitudinal and arcuate fasciculus. In contrast, lesions associated with comprehension deficits were found more ventral-anterior in the temporoprefrontal region with a statistical lesion maximum between the insular cortex and the putamen in projection of the ventral extreme capsule. Individual lesion overlap with the dorsal fibre tract showed a significant negative correlation with repetition performance, whereas lesion overlap with the ventral fibre tract revealed a significant negative correlation with comprehension performance. To summarize, our results from patients with acute stroke lesions support the claim that language is organized along two segregated dorsal–ventral streams. Particularly, this is the first lesion study demonstrating that task performance on auditory comprehension measures requires an interaction between temporal and prefrontal brain regions via the ventral extreme capsule pathway.
Modular localization of massive particles with ``any'' spin in d=2+1

We discuss a concept of particle localization which is motivated from quantum field theory, and has been proposed by Brunetti, Guido and Longo and by Schroer. It endows the single-particle Hilbert space with a family of real subspaces indexed by the space–time regions, with certain specific properties reflecting the principles of locality and covariance. We show by construction that such a localization structure exists also in the case of massive anyons in d=2+1, i.e., for particles with positive mass and with arbitrary spin s∈R. The construction is completely intrinsic to the corresponding ray representation of the (proper orthochronous) Poincare group. Our result is of particular interest since there are no free fields for anyons, which would fix a localization structure in a straightforward way. We present explicit formulas for the real subspaces, expected to turn out useful for the construction of a quantum field theory for anyons. In accord with well-known results, only localization in string-like, i.
mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action*

The mammalian target of rapamycin (mTOR) Ser/Thr kinase signals in at least two multiprotein complexes distinguished by their different partners and sensitivities to rapamycin. Acute rapamycin inhibits signaling by mTOR complex 1 (mTORC1) but not mTOR complex 2 (mTORC2), which both promote cell growth, proliferation, and survival. Although mTORC2 regulation remains poorly defined, diverse cellular mitogens activate mTORC1 signaling in a manner that requires sufficient levels of amino acids and cellular energy. Before the identification of distinct mTOR complexes, mTOR was reported to autophosphorylate on Ser-2481 in vivo in a rapamycin- and amino acid-insensitive manner. These results suggested that modulation of mTOR intrinsic catalytic activity does not universally underlie mTOR regulation. Here we re-examine the regulation of mTOR Ser-2481 autophosphorylation (Ser(P)-2481) in vivo by studying mTORC-specific Ser(P)-2481 in mTORC1 and mTORC2, with a primary focus on mTORC1. In contrast to previous work, we find that acute rapamycin and amino acid withdrawal markedly attenuate mTORC1-associated mTOR Ser(P)-2481 in cycling cells. Although insulin stimulates both mTORC1- and mTORC2-associated mTOR Ser(P)-2481 in a phosphatidylinositol 3-kinase-dependent manner, rapamycin acutely inhibits insulin-stimulated mTOR Ser(P)-2481 in mTORC1 but not mTORC2. By interrogating diverse mTORC1 regulatory input, we find that without exception mTORC1-activating signals promote, whereas mTORC1-inhibitory signals decrease mTORC1-associated mTOR Ser(P)-2481. These data suggest that mTORC1- and likely mTORC2-associated mTOR Ser-2481 autophosphorylation directly monitors intrinsic mTORC-specific catalytic activity and reveal that rapamycin inhibits mTORC1 signaling in vivo by reducing mTORC1 catalytic activity.
Prevalence of refractive error, presbyopia, and unmet need of spectacle coverage in a northern district of Bangladesh: Rapid Assessment of Refractive Error study

ABSTRACT Purpose: To determine the prevalence of refractive error (RE), presbyopia, spectacle coverage, and barriers to uptake optical services in Bangladesh. Method: Rapid assessment of refractive error (RARE) study following the RARE protocol was conducted in a northern district (i.e., Sirajganj) of Bangladesh (January 2010–December 2012). People aged 15–49 years were selected, and eligible participants had habitual distance and near visual acuity (VA) measured and ocular examinations were performed in those with VA<6/18. Those with phakic eyes with VA <6/18, but improving to ≥6/18 with pinhole or optical correction, were considered as RE and people aged ≥35 years with binocular unaided near vision of <N8 were considered presbyopic. Result : A total of 3,043 people were examined, of which 143 had RE (4.7%, 95% CI: 3.9–5.5). Among people aged ≥35 years (n = 1402), 869 had presbyopia (62.0, 95% CI: 59.4–64.5). Spectacle coverage for RE and presbyopia were 13.3% (95% CI 7.7–18.9) and 3.2% (95% CI 2.2–4.6), respectively. “Unaware of the problem” was the main reason for not utilizing any optical services among the people with RE (92.8%) and presbyopia (89.5%). Extrapolating the survey findings to the 2011 national census data, the magnitude of RE among people aged 15–49 years in Bangladesh is estimated to be 3,493,980 people (95% CI 2,899,260–4,088,700), of whom 3,029,280 people do not use any spectacles. Conclusion : The burden of RE and presbyopia is substantial in Bangladesh. Improving awareness and availability of refraction services is required to correct REs and presbyopia in Bangladesh.
Financial Risk Management in Enterprises that are Members of European Federation of Energy Traders

Rad istražuje upravljanje rizikom promjena cijena elektricne energije u poduzecima clanicama Europskog udruženja trgovaca energijom. Istraživanje je potaknuto visokom volatilnoscu cijena energenata na međunarodnim tržistima te znacajnim gubicima u poslovanju koji su nastali zbog izloženosti poduzeca tim cjenovnim promjenama. Upravo ovi trendovi poticu da se upravljanju rizicima u energetskom sektoru danas posvecuje sve veca pozornost. U radu su se analizirale osnovne odrednice odluke o upravljanju rizikom cijene elektricne energije u analiziranim poduzecima te je testirana valjanost hipoteza vezanih uz opravdanost funkcije upravljanja rizicima i njezin utjecaj na povecanje vrijednosti poduzeca. Istražilo se utjecu li navedene teorije, kao i određene karakteristike poduzeca poput zaduženosti, velicine, likvidnosti te vrijednosti ulaganja, na odluku o upravljanju rizikom promjene cijene elektricne energije u poduzecima clanicama EFET-a. Potvrđena je hipoteza da su velicina i zaduženost poduzeca utjecajni cimbenici odluke o upravljanju cjenovnim rizikom. Ovi rezultati sukladni su nalazima prethodnih istraživanja i potvrđuju utjecaj troskova financijskih poteskoca te ekonomije razmjera na opravdanost funkcije upravljanja rizicima u poduzecu. Suprotno tome, teorija skupog vanjskog financiranja ne objasnjava aktivnosti upravljanja cjenovnim rizikom u analiziranim poduzecima jer je dokazano da poduzeca koja imaju vise internih sredstava imaju vecu potrebu za hedžiranjem svojih pozicija.
Graph-based surface reconstruction from stereo pairs using image segmentation

This paper describes a novel stereo matching algorithm for epipolar rectified images. The method applies colour segmentation on the reference image. The use of segmentation makes the algorithm capable of handling large untextured regions, estimating precise depth boundaries and propagating disparity information to occluded regions, which are challenging tasks for conventional stereo methods. We model disparity inside a segment by a planar equation. Initial disparity segments are clustered to form a set of disparity layers, which are planar surfaces that are likely to occur in the scene. Assignments of segments to disparity layers are then derived by minimization of a global cost function via a robust optimization technique that employs graph cuts. The cost function is defined on the pixel level, as well as on the segment level. While the pixel level measures the data similarity based on the current disparity map and detects occlusions symmetrically in both views, the segment level propagates the segmentation information and incorporates a smoothness term. New planar models are then generated based on the disparity layers' spatial extents. Results obtained for benchmark and self-recorded image pairs indicate that the proposed method is able to compete with the best-performing state-of-the-art algorithms.
Sensitivity Enhancement in Magnetic Particle Imaging by Background Subtraction

Biomedical applications such as cell tracking and angiography require the detection of low concentrations of superparamagnetic iron oxide nanoparticles (SPIOs) for imaging purposes. Magnetic particle imaging (MPI) is a new technology which enables the quantitative and time-resolved localization of SPIO distributions. However, the minimum concentration at which the SPIOs can be reconstructed with a suitable quality still remains to be investigated. In this work we examine the background signals in raw data that were measured without any SPIOs in the scanner tube. We show that a background subtraction in combination with a frequency cutoff for the dynamic part of the background signal lowers the detection limit for SPIOs in MPI up to a factor of ten. In-vivo mouse experiments show that for early time points from when the tracer enters the vena cava a reconstructed image of sufficient quality can only be obtained when a background subtraction is performed.
Integrating petrogenesis and weathering to understand regolith chemistry: examples from the Palaeoproterozoic Carson Volcanics, north Kimberley, Western Australia

The rugged topography of the Kimberley area of northern Western Australia preserves examples of the complete weathering cycle to produce regolith. With increasing weathering intensity, Palaeoproterozoic mafic volcanic rocks of the Carson Volcanics are progressively depleted in low field strength element (LFSE) and rare earth elements (REE), and enriched in high-field strength elements (HFSE), Th, Cr and chalcophile elements. This reflects the breakdown of the main rock-forming minerals, the concentration of resistate phases such as zircon, chromite, monazite and rutile, and the development of secondary clay minerals, oxides and oxyhydroxides. Some regolith samples at the base of the volcanic succession have high Cr, As and detectable Au and Pd. This regolith chemistry reflects not only the intensity of weathering, but also the less fractionated and weakly mineralized nature of flow units erupted early in the volcanic cycle. Elsewhere in the Carson Volcanics, two regolith samples with unusually high concentrations of Ba, REE and Zn are located close to regional structures, which acted as conduits along which hydrothermal fluids migrated resulting in surface alteration, probably after regolith formation. Both examples show that regolith chemistry should be interpreted in the context of both weathering and petrogenetic processes that affect bedrock composition.
Joint Detection and Tracking Processing Algorithm for Target Tracking in Multiple Radar System

In this paper, a joint detection and tracking processing (JDTP) algorithm is proposed for target tracking in clutter using a multiple radar system. In this paper, the data association events are formed with a reasonable assumption that each radar can at most receive one measurement originated from a target. Moreover, we explore the idea of feeding the information from the tracker to the detector. In this scenario, the tracker can guide the detectors of multiple radars where to look for a target while keeping the constant false alarm rate property. From a practical point of view, the detection threshold is depressed near where a target is expected to be and elevated where it is unexpected. Simulation results demonstrate the efficiency of the proposed JDTP algorithm, in terms of the detection and the tracking performance, when compared with the existing works.