Miracle-dz/UniFAR-FTUs huggingface dataset:
Does Exercise Training Improve Cardiac-Parasympathetic Nervous System Activity in Sedentary People? A Systematic Review with Meta-Analysis

The aim of this study was to investigate the training-induced effect on cardiac parasympathetic nervous system (PNS) activity, assessed by resting heart rate variability (HRV) and post-exercise heart rate recovery (HRR), in sedentary healthy people. Electronic searches were carried out in PubMed, Embase, and Web of Science. Random-effects models of between-group standardised mean difference (SMD) were estimated. Heterogeneity analyses were performed by means of the chi-square test and I2 index. Subgroup analyses and meta-regressions were performed to investigate the influence of potential moderator variables on the training-induced effect. The results showed a small increase in RMSSD (SMD+ = 0.57 [95% confidence interval (CI) = 0.23, 0.91]) and high frequency (HF) (SMD+ = 0.21 [95% CI = 0.01, 0.42]) in favour of the intervention group. Heterogeneity tests reached statistical significance for RMSSD and HF (p ≤ 0.001), and the inconsistency was moderate (I2 = 68% and 60%, respectively). We found higher training-induced effects on HF in studies that performed a shorter intervention or lower number of exercise sessions (p ≤ 0.001). Data were insufficient to investigate the effect of exercise training on HRR. Exercise training increases cardiac PNS modulation in sedentary people, while its effect on PNS tone requires future study.
Spectro-astrometry of the pre-transitional star LkCa 15 does not reveal an accreting planet but extended Hα emission

Context. The detection of forming planets in protoplanetary disks around young stars remains elusive, and state-of-the-art observational techniques provide somewhat ambiguous results. The pre-transitional T Tauri star LkCa 15 is an excellent example. It has been reported that it could host three planets; candidate planet b is in the process of formation, as inferred from its Hα emission. However, a more recent work casts doubts on the planetary nature of the previous detections. Aims. We test the potential of spectro-astrometry in Hα as an alternative observational technique to detect forming planets around young stars, taking LkCa 15 as a reference case Methods. LkCa 15 was observed with the ISIS spectrograph at the 4.2 m William Herschel Telescope (WHT). The slit was oriented towards the last reported position of LkCa 15 b (parallel direction) and 90° from that (perpendicular). The photocenter and full width half maximum (FWHM) of the Gaussians fitting the spatial distribution at Hα and the adjacent continuum were measured. A wellknown binary (GU CMa) was used as a calibrator to test the spectro-astrometric performance of ISIS/WHT. Results. A consistent spectro-astrometric signature is recovered for GU CMa. However, the photocenter shift predicted for LkCa 15 b is not detected, but the FWHM in Hα is broader than in the continuum for both slit positions. Our simulations show that the photocenter and FWHM observations cannot be explained simultaneously by an accreting planet, but the lack of photocenter shift alone could still be consistent with an emitting planet with contrast ≳5.5 mag in Hα or ≲6 mag in the adjacent continuum. In turn, both spectro-astrometric observations are naturally reproduced from a roughly symmetric Hα emitting region centered on the star and extent comparable to the orbit originally attributed to the planet at several au. Conclusions. The extended Hα emission around LkCa 15 could be related to a variable disk wind, but additional multi-epoch data and detailed modeling are necessary to understand its physical nature. Optical spectro-astrometry carried out with mid-size telescopes is capable of probing small-scale structures in relatively faint young stars that are not easily accessible with state-of-the-art instrumentation mounted on larger telescopes. Therefore, spectro-astrometry in Hα is able to test the presence of accreting planets and can be used as a complementary technique to survey planet formation in circumstellar disks.
Novel BH4-BCL-2 Domain Antagonists Induce BCL-2-Mediated Apoptosis in Triple-Negative Breast Cancer

Simple Summary Our work has led to the identification of three novel BH4 mimetics, SM216, SM396, and SM949, with nanomolar activities both in vitro and in vivo assays. SM396 binds covalently to the BH4 domain of BCL-2 while the compounds SM216 and SM949 are non-covalent BH4 binders. Our results illustrate that these compounds are highly specific to the triple-negative breast cancer cells with no effect on normal cells. Elevated levels of Cyt-c induced by these compounds suggest significant inhibition of BCL-2 leading to apoptosis. Further investigations of these potent lead compounds will lead to clinical translations in targeting challenging tumor types. Abstract Targeting the challenging tumors lacking explicit markers and predictors for chemosensitivity is one of the major impediments of the current cancer armamentarium. Triple-negative breast cancer (TNBC) is an aggressive and challenging molecular subtype of breast cancer, which needs astute strategies to achieve clinical success. The pro-survival B-cell lymphoma 2 (BCL-2) overexpression reported in TNBC plays a central role in deterring apoptosis and is a promising target. Here, we propose three novel BH4 mimetic small molecules, SM396, a covalent binder, and two non-covalent binders, i.e., SM216 and SM949, which show high binding affinity (nM) and selectivity, designed by remodeling the existing BCL-2 chemical space. Our mechanistic studies validate the selectivity of the compounds towards cancerous cells and not on normal cells. A series of functional assays illustrated BCL-2-mediated apoptosis in the tumor cells as a potent anti-cancerous mechanism. Moreover, the compounds exhibited efficacious in vivo activity as single agents in the MDA-MB-231 xenograft model (at nanomolar dosage). Overall, these findings depict SM216, SM396, and SM949 as promising leads, pointing to the clinical translation of these compounds in targeting triple-negative breast cancer.
The Galaxy Stellar Mass Function and Low Surface Brightness Galaxies from Core-Collapse Supernovae

We introduce a method for producing a galaxy sample unbiased by surface brightness and stellar mass, by selecting star-forming galaxies via the positions of core-collapse supernovae (CCSNe). Whilst matching $\sim$2400 supernovae from the SDSS-II Supernova Survey to their host galaxies using IAC Stripe 82 legacy coadded imaging, we find $\sim$150 previously unidentified low surface brightness galaxies (LSBGs). Using a sub-sample of $\sim$900 CCSNe, we infer CCSN-rate and star-formation rate densities as a function of galaxy stellar mass, and the star-forming galaxy stellar mass function. Resultant star-forming galaxy number densities are found to increase following a power-law down to our low mass limit of $\sim10^{6.4}$ M$_{\odot}$ by a single Schechter function with a faint-end slope of $\alpha = -1.41$. Number densities are consistent with those found by the EAGLE simulations invoking a $\Lambda$-CDM cosmology. Overcoming surface brightness and stellar mass biases is important for assessment of the sub-structure problem. In order to estimate galaxy stellar masses, a new code for the calculation of galaxy photometric redshifts, zMedIC, is also presented, and shown to be particularly useful for small samples of galaxies.
Experimental Investigation of the Absorption Behavior of Date Palm Fiber Reinforced Iso-Polyester Composites: Artificial Neuron Network (ANN) Modeling

ABSTRACT The present article attempts to study absorption properties of bio-composites reinforced with date palm fibers. The effect of fiber loading on water absorption at room temperature 25°C was investigated. The weight gain was measured of bio-composites immersed in distilled water, seawater and rainwater, for more than 670 hours, until reaching the saturation with a measurement interval between 24 and 48 hours. To understand absorption phenomenon, scanning electron microscopy was used. Porosity rate was determined using image J software. It was noted the water absorption rate of the bio composites reached 16.20%, 16.33%, 21.94%, 41.99% for seawater, 16.41%, 16.52%, 20.84%, 30.08% for distilled water, and 14.00%, 14.04%, 19.30%, 36.94% for rainwater, respectively. The absorption increases when increasing fiber content. The diffusion coefficient of bio-composites has minimum and maximum values of about 1.94 × 10−6mm2/s and 3.99 × 10−6mm2/s, respectively. Palm fibers are highly porous. The porosity value was higher than 51%. To predict the absorption rate, artificial neural network method was used. The ANN models obtained are very well correlated with the experimental data where the values of the correlation coefficient of the datasets are all beyond 0.99 and the average error value was estimated at 3 × 10−5.
A 22-Site Comparison of Land-Use Practices, E-coli and Enterococci Concentrations

Land-use practices can greatly impact water quality. Escherichia (E.) coli and Enterococcus are accepted water quality indicators. However, surprisingly little research has been conducted comparing both organisms’ population density relationships to land use practices and water quality. Stream water grab samples were collected monthly (n = 9 months) from 22 stream monitoring sites draining varying land use practice types in a representative mixed-land-use watershed of the northeastern United States. E. coli and enterococci colony forming units (CFU per 100 mL) were estimated (n = 396) and statistically analyzed relative to land use practices, hydroclimate, and pH, using a suite of methods, including correlation analysis, Principal Components Analysis (PCA), and Canonical Correspondence Analysis (CCA). Correlation analyses indicated significant (p < 0.05) relationships between fecal indicator bacteria concentrations, water quality metrics and land use practices but emphasized significant (p < 0.05) negative correlations between pH and instream enterococci concentrations. PCA and CCA results indicated consistent spatial differences between fecal indicator bacteria concentrations, pH, and land use/land cover characteristics. The study showed that pH could be considered an integrated proxy variable for past (legacy) and present land use practice influences. Results also bring to question the comparability of E-coli and enterococci relative to dominant land use practices and variations in pH and provide useful information that will help guide land use practice and water pollutant mitigation decision making.
A Portable, Negative-Pressure Actuated, Dynamically Tunable Microfluidic Droplet Generator

Droplet microfluidics utilize a monodisperse water-in-oil emulsion, with an expanding toolbox offering a wide variety of operations on a range of droplet sizes at high throughput. However, translation of these capabilities into applications for non-expert laboratories to fully harness the inherent potential of microscale manipulations is woefully trailing behind. One major obstacle is that droplet microfluidic setups often rely on custom fabricated devices, costly liquid actuators, and are not easily set up and operated by non-specialists. This impedes wider adoption of droplet technologies in, e.g., the life sciences. Here, we demonstrate an easy-to-use minimal droplet production setup with a small footprint, built exclusively from inexpensive commercially sourced parts, powered and controlled by a laptop. We characterize the components of the system and demonstrate production of droplets ranging in volume from 3 to 21 nL in a single microfluidic device. Furthermore, we describe the dynamic tuning of droplet composition. Finally, we demonstrate the production of droplet-templated cell spheroids from primary cells, where the mobility and simplicity of the setup enables its use within a biosafety cabinet. Taken together, we believe this minimal droplet setup is ideal to drive broad adoption of droplet microfluidics technology.
Three-dimensional Hydrodynamical Simulations of Mass Transfer in Binary Systems by a Free Wind

A large fraction of stars in binary systems are expected to undergo mass and angular momentum exchange at some point in their evolution, which can drastically alter the chemical and dynamical properties and fates of the systems. Interaction by stellar wind is an important process in wide binaries. However, the details of wind mass transfer are still not well understood. We perform three-dimensional hydrodynamical simulations of wind mass transfer in binary systems to explore mass-accretion efficiencies and geometries of mass outflows, for a range of mass ratios from 0.05 to 1.0. In particular, we focus on the case of a free wind, in which some physical mechanism accelerates the expelled wind material balancing the gravity of the mass-losing star with the wind velocity comparable to the orbital velocity of the system. We find that the mass-accretion efficiency and accreted specific angular momentum increase with the mass ratio of the system. For an adiabatic wind, we obtain that the accretion efficiency onto the secondary star varies from about 0.1% to 8% for mass ratios between 0.05 and 1.0.
A New Multiplet Table for Fe

We have recorded spectra of iron-neon and iron-argon hollow cathode lamps in the region 1700A -- 5um (59000 -- 2000cm-1), with Fourier transform (FT) spectrometers at the National Solar Observatory, Tucson, Arizona, U.S.A. and Imperial College, London, U.K., and with a high resolution grating spectrograph at the National Institute of Standards and Technology, Gaithersburg, U.S.A. The uncertainty of the strongest lines in the FT spectra is <0.002cm-1 (0.2mA at 3000A; 8mA at 2um). Pressure and current-dependent shifts are <0.001cm-1 for transitions between low lying levels, increasing to 0.006 cm-1 for transitions between the most highly excited levels. We report 28 new energy levels of Fe I and revised values of another 818 levels. We have identified 9501 lines as due to 9759 transitions in Fe I, and these are presented in the form of a new multiplet table and finding list. This compares with the 5500 lines due to 467 energy levels in the multiplet tables of Moore (1950, 1959). The biggest increase is in the near ultraviolet and near infra-red, and many of the new lines are present in the solar spectrum. Experimental log(gf) values are included where available. A further 125 unidentified lines due to Fe I are given.
The Significance of p-AKT1 as a Prognostic Marker and Therapeutic Target in Patients With Hormone Receptor-Positive and Human Epidermal Growth Factor Receptor-2-Positive Early Breast Cancer

Purpose Phosphorylated AKT1 (p-AKT1) at Ser473 is a functional isoform of AKT and a key component of the PI3K/mTOR/AKT pathway. This study aimed to evaluate the prognostic significance of p-AKT1 (Ser473) based on the molecular subtypes of breast cancer. Methods To investigate the prognostic value of p-AKT1 (Ser473), we performed a retrospective chart review of patients with breast cancer. Data on p-AKT1 (Ser473) positivity, hormone receptor (HR) status, human epidermal growth factor receptor 2 (HER2) expression status, and other clinicopathological factors were obtained. Furthermore, the therapeutic effect of blocking p-AKT1 (Ser473) in breast cancer cells was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, cell apoptosis assay, apoptosis protein array, and western blot analysis. Results A total of 3,044 patients were evaluated, and the median follow-up time was 43 (range: 0–125) months. In patients with HR-positive and HER2-positive disease, the p-AKT1 (Ser473)-positive group had worse disease-free survival (DFS) than the p-AKT1 (Ser473)-negative group (hazard ratio, 1.9; 95% confidence interval, 1.1–3.5; p = 0.024). In the multivariate analysis, p-AKT1 (Ser473) remained a significantly worse prognostic factor in patients with HR-positive/HER2-positive breast cancer (p = 0.03). There was no difference in DFS according to p-AKT1 (Ser473) status among patients with other breast cancer subgroups. In vitro analysis showed that blocking p-AKT1 (Ser473) levels enhanced trastuzumab-induced cell death in HR-positive/HER2-positive and p-AKT1 (Ser473)-positive breast cancer cells. Conclusion p-AKT1 (Ser473) is a prognostic marker for poor outcomes in patients with HR-positive/HER2-positive breast cancer and may have a potential value as a therapeutic target.
Chestnut Lily Beverage (CLB) Processing Using Ultrasound-Assisted Nisin: Microbiota Inactivation and Product Quality

We evaluated the effects of ultrasound (US) and ultrasound combined with nisin (NUS) treatments on the properties of chestnut lily beverages (CLB) using conventional thermal pasteurisation (TP) as a control. After CLB samples were treated with US and NUS for 20, 40, or 60 min, the polyphenol oxidase activity (PPO), microbial inactivation effect, colour, pH value, total phenolic content, and antioxidant capacity of the CLB were observed. It was found that the inactivation rate of PPO in CLB after NUS treatment was higher than that in the US, indicating that NUS treatment aggravated PPO inactivation. Treatment time was important in the inactivation of microorganisms by US and NUS; NUS had a lethal synergistic lethal effect on microorganisms in CLB and when compared with US, NUS reduced changes in the CLB colour value. Notably, the total phenolic content and antioxidant capacity of the US- and NUS-treated CLB significantly increased relative to the TP group. These results that suggest NUS has a potential application value in the development of CLB because it reduces the risk of microorganism contamination and helps improve the quality of CLB. This study provides technical support and a theoretical basis for the improved production of CLB.
Chicken chromatin accessibility atlas accelerates epigenetic annotation of birds and gene fine-mapping associated with growth traits

The development of epigenetic maps, such as the ENCODE project in humans, provides resources for gene regulation studies and a reference for research of disease-related regulatory elements. However, epigenetic information, such as a bird-specific chromatin accessibility atlas, is currently lacking for the thousands of bird species currently described. The major genomic difference between birds and mammals is their shorter introns and intergenic distances, which seriously hinders the use of humans and mice as a reference for studying the function of important regulatory regions in birds. In this study, using chicken as a model bird species, we systematically compiled a chicken chromatin accessibility atlas using 53 Assay of Transposase Accessible Chromatin sequencing (ATAC-seq) samples across 11 tissues. An average of 50 796 open chromatin regions were identified per sample, cumulatively accounting for 20.36% of the chicken genome. Tissue specificity was largely reflected by differences in intergenic and intronic peaks, with specific functional regulation achieved by two mechanisms: recruitment of several sequence-specific transcription factors and direct regulation of adjacent functional genes. By integrating data from genome-wide association studies, our results suggest that chicken body weight is driven by different regulatory variants active in growth-relevant tissues. We propose CAB39L (active in the duodenum), RCBTB1 (muscle and liver), and novel long non-coding RNA ENSGALG00000053256 (bone) as candidate genes regulating chicken body weight. Overall, this study demonstrates the value of epigenetic data in fine-mapping functional variants and provides a compendium of resources for further research on the epigenetics and evolution of birds and mammals.
Adaptive Fuzzy-Sliding Consensus Control for Euler-Lagrange Systems with Time-Varying Delays

This paper presents an adaptive fuzzy sliding-mode controller for multiple Euler–Lagrange systems communicated with directed topology. Based on the graph theory and Lyapunov–Krasovskii functions, a delay-dependent sufficient condition for the existence of sliding surfaces is given in terms of linear matrix inequalities. The asymptotic stability is analyzed by using the Lyapunov method in the presence of unknown parametric dynamics, actuator faults, and time-varying delays. The usage of adaptive techniques is to adapt the unknown parameters so that the objective of globally asymptotic stability is achieved. Finally, simulation results are provided to illustrate the effectiveness of the proposed control scheme.
Theory & observations of the PWN-SNR complex

In this work, we study theoretical and observational issues about pulsars (PSRs), pulsar wind nebulae (PWNe) and supernova remnants (SNRs). In particular, the spectral modeling of young PWNe and the X-ray analysis of SNRs with magnetars comparing their characteristics with those remnants surrounding canonical pulsars. The spectra of PWNe range from radio to $\gamma$-rays. They are the largest class of identified Galactic sources in $\gamma$-rays increasing the number from 1 to $\sim$30 during the last years. We have developed a detailed spectral code which reproduces the electromagnetic spectrum of PWNe in free expansion ($t_{age} \lesssim$10 kyr). We shed light and try to understand issues on time evolution of the spectra, the synchrotron self-Compton dominance in the Crab Nebula, the particle dominance in PWNe detected at TeV energies and how physical parameters constrain the detectability of PWNe at TeV. We make a systematic study of all Galactic, TeV-detected, young PWNe which allows to find correlations and trends between parameters. We also discuss about the spectrum of those PWNe not detected at TeV and if models with low magnetized nebulae can explain the lack of detection or, on the contrary, high-magnetization models are more favorable. Regarding the X-ray analysis of SNRs, we use X-ray spectroscopy in SNRs with magnetars to discuss about the formation mechanism of such extremely magnetized PSRs. The alpha-dynamo mechanism proposed in the 1990's produces an energy release that should have influence in the energy of the SN explosion. We extend the work done previously done by \cite{vink06} about the energetics of the SN explosion looking for this energy release and we look for the element ionization and the X-ray luminosity and we compare our results with other SNRs with an associated central source.
Correction of attenuated C-band reflectivity fields by means of a variational method

Attenuation is one of the most important prob- lems for precipitation estimation at wavelengths shorter than 10 cm. However, for most of the existing radars no correction for attenuation is implemented due to the instabilities of the inversion equation, already shown by Hitschfeld and Bordan in 1954. The present study proposes a methodology based on the minimization of a cost function that imposes the corrected field to be "close" to the analytical solution and, at the same time, to satisfy some constraints. One of these constraints comes from the orographic returns, assuming that the Path Integrated Attenuation may be estimated as the difference be- tween clear-air and rainy conditions (similarly to the Moun- tain Reference Technique). The performance of the methodology has been tested in the case of C-band radars under some simplifying assump- tions and corrected fields are validated against the measure- ments of a network of raingages.