Miracle-dz/UniFAR-FTUs huggingface dataset:
Three-dimensional hydrodynamical CO5BOLD model atmospheres of red giant stars. V. Oxygen abundance in the metal-poor giant HD 122563 from OH UV lines

Although oxygen is an important tracer of the early Galactic evolution, its abundance trends with metallicity are still relatively poorly known at [Fe/H] < -2.5. This is in part due to a lack of reliable oxygen abundance indicators in the metal-poor stars, in part due to shortcomings in 1D LTE abundance analyses. In this study we determined the oxygen abundance in the metal-poor halo giant HD 122563 using a 3D hydrodynamical CO5BOLD model atmosphere. Our main goal was to understand whether a 3D LTE analysis may help to improve the reliability of oxygen abundances determined from OH UV lines in comparison to those obtained using standard 1D LTE methodology. The oxygen abundance in HD 122563 was determined using 71 OH UV lines located in the wavelength range between 308-330 nm. The analysis was done using a high-resolution VLT UVES spectrum with a 1D LTE spectral line synthesis performed using the SYNTHE package and classical ATLAS9 model atmosphere. Subsequently, a 3D hydrodynamical CO5BOLD, and 1D hydrostatic LHD model atmospheres were used in order to compute 3D-1D abundance corrections. For this, the microturbulence velocity used with the 1D LHD model atmosphere was derived from the hydrodynamical CO5BOLD model atmosphere. As in previous studies, we found trends of the 1D LTE oxygen abundances determined from OH UV lines with line parameters, such as the line excitation potential and the line strength. These trends become significantly less pronounced in 3D LTE. Using OH UV lines we determined a 3D LTE oxygen abundance in HD 122563 of A(O) = 6.23 +/- 0.13. This is in fair agreement with the oxygen abundance obtained from OH IR lines, A(O) = 6.39 +/- 0.11, but it is noticeably lower than that determined using the forbidden [OI] line, A(O) = 6.53 +/- 0.15. While the exact cause for this discrepancy remains unclear, it is very likely that non-LTE effects may play a decisive role here.
Beta Dips in the Gaia Era: Simulation Predictions of the Galactic Velocity Anisotropy Parameter (β) for Stellar Halos

The velocity anisotropy parameter, β, is a measure of the kinematic state of orbits in the stellar halo, which holds promise for constraining the merger history of the Milky Way (MW). We determine global trends for β as a function of radius from three suites of simulations, including accretion-only and cosmological hydrodynamic simulations. We find that the two types of simulations are consistent and predict strong radial anisotropy ( ) for Galactocentric radii greater than 10 kpc. Previous observations of β for the MW’s stellar halo claim a detection of an isotropic or tangential “dip” at r ∼ 20 kpc. Using the N-body+SPH simulations, we investigate the temporal persistence, population origin, and severity of “dips” in β. We find that dips in the in situ stellar halo are long-lived, while dips in the accreted stellar halo are short-lived and tied to the recent accretion of satellite material. We also find that a major merger as early as z ∼ 1 can result in a present-day low (isotropic to tangential) value of β over a broad range of radii and angles. While all of these mechanisms are plausible drivers for the β dip observed in the MW, each mechanism in the simulations has a unique metallicity signature associated with it, implying that future spectroscopic surveys could distinguish between them. Since an accurate knowledge of β(r) is required for measuring the mass of the MW halo, we note that significant transient dips in β could cause an overestimate of the halo’s mass when using spherical Jeans equation modeling.
Energy Security of Hydropower Producing Countries—The Cases of Tajikistan and Kyrgyzstan

Energy security, as one of the most important components of state security, is a permanent element of academic debates and political discussions. Owing to the multidimensional and multifaceted nature of energy security, defining it is a complex process, requiring the consideration of a wide range of factors straddling economics, geology, ecology and geopolitics which decide whether we are dealing with the state of energy security or the lack of it. Energy security is usually equated with the security of supply. Another group of definitions of energy security focuses on the concept of security of services. A different approach to energy security issues is presented by energy exporting countries, whose objective is to ensure sufficiently high and stable income from sales of energy resource exports (security of demand). The subject of this paper is an analysis of the energy security of hydropower-producing countries—Tajikistan and Kyrgyzstan. Energy security has been analyzed in the context of security of supply, services, and demand on the basis of the approach proposed by Llamosas and Sovacool. So far, no work has been carried out to analyse the hydropower sectors of Kyrgyzstan and Tajikistan in the context of the energy security comparison of both countries. It is worth emphasising that their energy security and mutual relations are important from the point of view of the stability of the entire Central Asian region. Kyrgyzstan and Tajikistan have large hydropower potential, which, if properly used, could cover their domestic electricity demand and the surplus can be exported to neighbouring countries. Unfortunately, both countries are not utilising this potential for the time being. The main difficulty in the area of security of supply and services is the seasonality and low reliability of electricity supplies. Among the reasons for this are the poor technical and economic conditions of energy companies as a result of maintaining low tariffs, the irrecoverability of consumers’ energy bills, electricity theft, significant transmission loses and a high level of corruption. Although both countries aspire to the role of an energy exporters, they are themselves forced to import electricity from neighboring countries.
Recognising Equivalent Algebraic Expressions: An Important Component of Algebraic Expectation for Working with CAS

The ability to recognize equivalent algebraic expressions quickly and confidently is important for doing mathematics in an intelligent partnership with computer algebra. It is also a key aspect of algebraic expectation, the algebraic skill that parallels numeric estimation. The progress in this ability of 50 students learning mathematics with CAS over two school years was monitored using a novel instrument called the Algebraic Expectation Quiz. Students began with very low facility and confidence and made moderate progress, confirming the importance of addressing this obstacle to using CAS explicitly in the curriculum. We offer conclusions about test items, students’ strengths and weaknesses and suggest possible teaching actions. The results demonstrate that recognizing equivalence, even in simple cases, is a significant obstacle for students.
Spectroscopy Study of Albumin Interaction with Negatively Charged Liposome Membranes: Mutual Structural Effects of the Protein and the Bilayers

Liposomes as drug carriers are usually injected into the systemic circulation where they are instantly exposed to plasma proteins. Liposome–protein interactions can affect both the stability of liposomes and the conformation of the associated protein leading to the altered biodistribution of the carrier. In this work, mutual effects of albumin and liposomal membrane in the course of the protein’s adsorption were examined in terms of quantity of bound protein, its structure, liposome membrane permeability, and changes in physicochemical characteristics of the liposomes. Fluorescence spectroscopy methods and Fourier transform infrared spectroscopy (ATR-FTIR), which provides information about specific groups in lipids involved in interaction with the protein, were used to monitor adsorption of albumin with liposomes based on egg phosphatidylcholine with various additives of negatively charged lipidic components, such as phosphatidylinositol, ganglioside GM1, or the acidic lipopeptide. Less than a dozen of the protein molecules were tightly bound to a liposome independently of bilayer composition, yet they had a detectable impact on the bilayer. Albumin conformational changes during adsorption were partially related to bilayer microhydrophobicity. Ganglioside GM1 showed preferable features for evading undesirable structural changes.
The Values and Cultural Characteristics of Defense Mechanisms in the COVID-19 Epidemic

Over the past three years, people have suffered from unimaginable psychological stress and anxiety caused by the COVID-19 epidemic. These stresses and anxieties stem from the threat that COVID-19 poses to people’s health and lives, as well as the negative impact of the government’s lockdown and quarantine policies on social economy and development. All these factors may put people in a state of stress and anxiety for a long time. However, any perceived stress can trigger the individual’s self-defense mechanism. To reduce anxiety from the epidemic, the automatic psychological processes are involuntarily activated, and the defense mechanisms are at work. This paper examines the performance of defense mechanisms during the epidemic based on news reports and the theory of defense mechanisms and illustrates the practical role and significance of understanding defense mechanisms for the public. Additionally, this paper also takes into account the potential cultural features of defensive systems.
Hydroxygenkwanin Improves the Efficacy of Cytotoxic Drugs in ABCG2-Overexpressing Multidrug-Resistant Cancer Cells

Hydroxygenkwanin, a flavonoid isolated from the leaves of the Daphne genkwa plant, is known to have pharmacological properties; however, its modulatory effect on multidrug resistance, which is (MDR) mediated by ATP-binding cassette (ABC) drug transporters, has not been investigated. In this study, we examine the interaction between hydroxygenkwanin, ABCB1, and ABCG2, which are two of the most well-characterized ABC transporters known to contribute to clinical MDR in cancer patients. Hydroxygenkwanin is not an efflux substrate of either ABCB1 or ABCG2. We discovered that, in a concentration-dependent manner, hydroxygenkwanin significantly reverses ABCG2-mediated resistance to multiple cytotoxic anticancer drugs in ABCG2-overexpressing multidrug-resistant cancer cells. Although it inhibited the drug transport function of ABCG2, it had no significant effect on the protein expression of this transporter in cancer cells. Experimental data showing that hydroxygenkwanin stimulates the ATPase activity of ABCG2, and in silico docking analysis of hydroxygenkwanin binding to the inward-open conformation of human ABCG2, further indicate that hydroxygenkwanin sensitizes ABCG2-overexpressing cancer cells by binding to the substrate-binding pocket of ABCG2 and attenuating the transport function of ABCG2. This study demonstrates the potential use of hydroxygenkwanin as an effective inhibitor of ABCG2 in drug combination therapy trials for patients with tumors expressing higher levels of ABCG2.
THE IMPORTANCE OF THE "MAGNETIC" COMPONENTS OF GRAVITATIONAL WAVES IN THE RESPONSE FUNCTIONS OF INTERFEROMETERS

With an enlighting analysis, Baskaran and Grishchuk have recently shown the presence and importance of the so-called "magnetic" components of gravitational waves (GWs), which have to be taken into account in the context of the total response functions of interferometers for GWs propagating from arbitrary directions. In this paper, more detailed angular and frequency dependences of the response functions for the magnetic components are given in the approximation of wavelength much larger than the linear dimensions of the interferometer, with a specific application to the parameters of the LIGO and Virgo interferometers. The results of this paper agree with the work of Baskaran and Grishchuk, in which it has been shown that the identification of "electric" and "magnetic" contributions is unambiguous in the long-wavelength approximation. At the end of this paper, the angular and frequency dependences of the total response functions of the LIGO and Virgo interferometers are given. In the high-frequency regime, the division on "electric" and "magnetic" components becomes ambiguous, thus the full theory of gravitational waves has to be used. Our results are consistent with the ones of Baskaran and Grishchuk for this case.
Cell Adhesion Molecules Affected by Ionizing Radiation and Estrogen in an Experimental Breast Cancer Model

Cancer develops in a multi-step process where environmental carcinogenic exposure is a primary etiological component, and where cell–cell communication governs the biological activities of tissues. Identifying the molecular genes that regulate this process is essential to targeting metastatic breast cancer. Ionizing radiation can modify and damage DNA, RNA, and cell membrane components such as lipids and proteins by direct ionization. Comparing differential gene expression can help to determine the effect of radiation and estrogens on cell adhesion. An in vitro experimental breast cancer model was developed by exposure of the immortalized human breast epithelial cell line MCF-10F to low doses of high linear energy transfer α particle radiation and subsequent growth in the presence of 17β-estradiol. The MCF-10F cell line was analyzed in different stages of transformation that showed gradual phenotypic changes including altered morphology, increase in cell proliferation relative to the control, anchorage-independent growth, and invasive capability before becoming tumorigenic in nude mice. This model was used to determine genes associated with cell adhesion and communication such as E-cadherin, the desmocollin 3, the gap junction protein alpha 1, the Integrin alpha 6, the Integrin beta 6, the Keratin 14, Keratin 16, Keratin 17, Keratin 6B, and the laminin beta 3. Results indicated that most genes had greater expression in the tumorigenic cell line Tumor2 derived from the athymic animal than the Alpha3, a non-tumorigenic cell line exposed only to radiation, indicating that altered expression levels of adhesion molecules depended on estrogen. There is a significant need for experimental model systems that facilitate the study of cell plasticity to assess the importance of estrogens in modulating the biology of cancer cells.
Practice Based Evidence (PBE) and therapies: personal recommendations from the 30 years of the CORE system (Evidencia basada en la práctica (EBP) y psicoterapias: recomendaciones personales basadas en los 30 años del sistema CORE)

Abstract Over the last 30 years we have seen two models of empirical evidence dominate funding for psychotherapies and for researching the psychotherapies. The first, still the dominant model, ‘Evidence-Based Practice (EBP)’ is based on Randomized Controlled Trial (RCT) evidence. More recently, Embedded Change Management (ECM) is the rising pre-paradigm, offering an alternative to EBP. I argue that neither model understands how evidence it is best shared between therapists as both are based on fundamentally flawed epistemologies and ideas of what constitutes pertinent evidence about the psychotherapies. Twenty-eight years ago, I was a co-creator of the CORE (Clinical Outcomes in Routine Exploration) system designed to support Practice-Based Evidence (PBE). I suggest that re-thinking the rather neglected PBE model at the heart of the original CORE system design might help change this situation. However, I recognize that the political models beneath both EBP and ECM create such vested interests within the ‘global North’ that real change will probably have to come from elsewhere.
Dwarf Galaxies Also Have Stellar Halos

We present evidence for the existence of an old stellar halo in the dwarf irregular galaxy WLM, an isolated member of the Local Group. The halo consists of Population II stars, with low metallicities and age ≥1010 yr. The finding of a halo in a dwarf irregular galaxy argues for a generic mode of galaxy formation that requires a halo in the presence of a disk, regardless of galaxy size. This implies that formation mechanisms are similar along the spiral Hubble sequence, and favors the scenarios where the formation takes place during the original collapse and accretion of the protogalactic gas clouds. Halo formation also appears not necessarily to be related to the presence of a bulge, or a nucleus, since WLM lacks both of these components.
Physical Impact of a Typical Training Session with Different Volumes on the Day Preceding a Match in Academy Soccer Players

French academies almost all implement reactivity drills and small-sided games (SSG) the day preceding a match (MD-1). The present study aimed to determine the physical impact of different training durations on MD-1 on the subsequent matchday performance (MD). Eleven elite U19 academy soccer players conducted three typical training sessions lasting 45 min (TS45), 60 min (TS60) and 75 min (TS75) on MD-1. During TS60, warm-up, reactivity and SSG were 10, 15 and 24 min, respectively, plus coaches’ feedback or water breaks. Durations of all training components decreased by 25% for TS45 and increased by 25% for TS75. Tests were conducted on MD-4 (CONTROL) and MD before the match (TEST). Tests consisted of a counter movement jump (CMJ), 20 m sprint, Illinois agility test (IAT) and Hooper questionnaire. CONTROL values were similar over the three experimental conditions. TEST on MD revealed greater CMJ for TS45 (42.7 ± 5.1 cm) compared to TS60 (40.5 ± 5.5 cm, p = 0.032) and TS75 (40.9 ± 5.7 cm, p = 0.037). 20 m time was lower for TS45 (3.07 ± 0.10 s, p < 0.001) and TS60 (3.13 ± 0.10 s, p = 0.017) compared to TS75 (3.20 ± 0.10 s). IAT time was lower on TS45 (14.82 ± 0.49 s) compared to TS60 (15.43 ± 0.29 s, p < 0.001) and TS75 (15.24 ± 0.33 s, p = 0.006). Furthermore, the Hooper index was lower at TEST for TS45 (7.64 ± 1.50) compared to TS60 (11.00 ± 3.49, p = 0.016) and TS75 (9.73 ± 2.41, p = 0.016), indicating a better readiness level. We concluded that, as training session duration increases, performance decreases on MD. A 45 min training session including reactivity and SSG exercises is therefore recommended on MD-1.
Reduction of kernel models

Kernel models can be expensive to compute and in non-stationary environments, can become unmanageably large. Here, we present several previously reported techniques for reducing the complexity of these models in a common framework. This reformulation leads to the development of further related reduction techniques and clarifies the relationships between these and the existing techniques.
Broad-band characteristics of seven new hard X-ray selected cataclysmic variables

We present timing and spectral analysis of a sample of seven hard X-ray selected Cataclysmic Variable candidates based on simultaneous X-ray and optical observations collected with XMM-Newton , complemented with Swift/BAT and INTEGRAL/IBIS hard X-ray data and ground-based optical photometry. For six sources, X-ray pulsations are detected for the first time in the range $\rm \sim296-6098\,s$, identifying them as members of the magnetic class. Swift J0927.7-6945, Swift J0958.0-4208, Swift J1701.3-4304, Swift J2113.5+5422, and possibly PBC J0801.2-4625, are Intermediate Polars (IPs), while Swift J0706.8+0325 is a short (1.7 h) orbital period Polar, the 11$^{\rm th}$ hard X-ray selected identified so far. X-ray orbital modulation is also observed in Swift J0927.7-6945 (5.2 h) and Swift J2113.5+5422 (4.1 h). Swift J1701.3-4304 is discovered as the longest orbital period (12.8 h) deep eclipsing IP. The spectra of the magnetic systems reveal optically thin multi-temperature emission between 0.2 and 60 keV. Energy dependent spin pulses and the orbital modulation in Swift J0927.7-6945 and Swift J2113.5+5422 are due to intervening local high density absorbing material ($\rm N_H\sim10^{22-23}\,cm^{-2}$). In Swift J0958.0-4208 and Swift J1701.3-4304, a soft X-ray blackbody (kT$\sim$50 and $\sim$80 eV) is detected, adding them to the growing group of "soft" IPs. White dwarf masses are determined in the range $\rm \sim0.58-1.18\,M_{\odot}$, indicating massive accreting primaries in five of them. Most sources accrete at rates lower than the expected secular value for their orbital period. Formerly proposed as a long-period (9.4 h) novalike CV, Swift J0746.3-1608 shows peculiar spectrum and light curves suggesting either an atypical low-luminosity CV or a low mass X-ray binary.
An observational test of the critical earthquake concept

We test the concept that seismicity prior to a large earthquake can be understood in terms of the statistical physics of a critical phase transition. In this model, the cumulative seismic strain release increases as a power law time to failure before the final event. Furthermore, the region of correlated seismicity predicted by this model is much greater than would be predicted from simple elastodynamic interactions. We present a systematic procedure to test for the accelerating seismicity predicted by the critical point model and to identify the region approaching criticality, based on a comparison between the observed cumulative energy (Benioff strain) release and the power law behavior predicted by theory. This method is used to find the critical region before all earthquakes along the San Andreas system since 1950 with M≥6.5. The statistical significance of our results is assessed by performing the same procedure on a large number of randomly generated synthetic catalogs. The null hypothesis, that the observed acceleration in all these earthquakes could result from spurious patterns generated by our procedure in purely random catalogs, is rejected with 99.5% confidence. An empirical relation between the logarithm of the critical region radius (R) and the magnitude of the final event (M) is found, such that log R∝0.5M, suggesting that the largest probable event in a given region scales with the size of the regional fault network.
Study on the Drying Technology of Tomato Pulp with Phytoene, Phytofluene and Lycopene Retention as Inspection Indexes

The objective was to design a feasible drying method to increase the retention rates of phytoene (PT), phytofluene (PTF) and lycopene (LYC) in tomato powder. The method was to compare the effects of vacuum freeze-drying (FD), vacuum drying (VD) and hot-air drying (HAD) technologies on tomato pulp rich in PT, PTF and LYC. When dried by HAD, the retention rates of PT, PTF and LYC decreased significantly (p < 0.05) only when the water content decreased from 30% to 3.5%. When dried by VD, the temperatures had no significant effect on the retention rates, and only alkaline conditions (pH = 9), Fe3+ and Al3+ could significantly reduce the retention rates (p < 0.05). Therefore, a combined drying process (CDP) was designed: before the water content decreased to 50%, HD (60 °C) technology was used; then, the paste was dried via VD (80 °C, 0.08 MPa) technology till the water content reached 5 ± 2%; loading weight was 40 g (thinkness 5.70 mm) for each batch. Compared with VD alone, the CDP technology improved the retention rates of PT and LYC by 12% and 36%, respectively, while PTF decreased by only 6%.
PERFORMANCE OF THE SYSTEMATIC DISTANCE-4 CODES OVER FADING CHANNELS

A new binary systematic linear block code construction technique, called as Systematic Distance-4 (SD-4) codes that generates all the optimal size Hamming distance-4 codes, is recently proposed. In this paper, we evaluate the error performance of some of the SD-4 codes to measure the coding gain of the codes over Rician and Rayleigh fading channels. We also compared the results with the error performance of the same size extended Hamming codes, which is the subset of SD-4 codes.