Miracle-dz/UniFAR-FTUs huggingface dataset:
Changes in the trajectory of the radio jet in 0735+178?

ABSTRA C T We present multi-epoch 8.4- and 43-GHz Very Long Baseline Array images of the BL Lac object 07351178. The images confirm the presence of a twisted jet with two sharp apparent bends of 908 within two milliarcseconds of the core, resembling a helix in projection. The observed twisted geometry could be the result of precession of the jet inlet, but is more likely produced by pressure gradients in the external medium through which the jet propagates. Quasi-stationary components are observed at the locations of the 908 bends, possibly produced by differential Doppler boosting. Identification of components across epochs, since the earliest VLBI observations of this source in 1979.2, proves difficult due to the sometimes large time gaps between observations. One possible identification suggests the existence of superluminal components following non-ballistic trajectories with velocities up to 11:6 ^ 0:6 h 21 65 c. However, in images obtained after mid-1995, components show a remarkable tendency to cluster near several jet positions, suggesting a different scenario in which components have remained nearly stationary in time, at least since mid-1995. Comparison with the earlier published data, covering more than 19 years of observations, suggests a striking qualitative change in the jet trajectory sometime between mid-1992 and mid-1995, with the twisted jet structure with stationary components becoming apparent only at the later epochs. This would require a re-evaluation of the physical parameters estimated for 07351178, such as the observing viewing angle, the plasma bulk Lorentz factor, and those deduced from these.
Community, Identity and Gender in Migrant Societies of Southern Africa: Emerging Epistemological Challenges

Immigration policy in South Africa is undergoing serious revision in response to unprecedented cross-border migration into the post-apartheid state. This article looks at the relevance of orthodox international relations theory to migration policy in South Africa, and argues that fundamental shifts in approach are essential if IR theorists of the region are to contribute effectively to understanding and managing migration in southern Africa. It builds on the results of interviews with migrants and considers the significance of the themes of identity, community and gender as areas of particular relevance to international relations theory.
Urokinase plasminogen activator receptor, beta 2-integrins, and Src- kinases within a single receptor complex of human monocytes

The glycosylphosphatidylinositol (GPI)-anchored membrane protein urokinase plasminogen activator-receptor (uPA-R; CD87) is one of the key molecules involved in migration of leukocytes and tumor cells. uPA bound to uPA-R provides the cell proteolytic potential used for degradation of extracellular matrix. uPA-R is also involved in induction of cell adhesion and chemotaxis. Here, we provide a molecular explanation for these uPA-R-related cellular events. By size fractionation of monocyte lysate and affinity isolation on its natural ligand uPA, we demonstrate uPA-R as a component of a receptor complex of relatively large size. Reprecipitation and immunoblotting techniques allowed us to detect the protein tyrosine kinases (PTKs) p60fyn, p53/56lyn, p58/64hck, and p59fgr as components of this "uPA-R complex". Activation of monocytes even with enzymatically inactivated uPA resulted in induction of tyrosine phosphorylation, suggesting modulation of uPA-R-associated PTKs upon ligand binding. In spite of their presence in large complexes, we did not find the GPI-linked proteins CD14, CD58, and CD59 in the uPA-R complex, which indicates the presence of different receptor domains containing GPI-linked proteins in monocytes. However, we identified the leukocyte integrins LFA-1 and CR3 as components of the uPA-R complex as indicated by coisolation of these molecules, as well as by cocapping and comodulation of uPA-R and leukocyte integrins on the monocyte surface. The assemblage of uPA-R, PTKs and membrane spanning beta 2-integrins in one receptor complex indicates functional cooperation. In regard to the involvement of these molecules in pericellular proteolysis, signal transduction, as well as adhesion and chemotactic movement, we suggest uPA-R complex as a potential cellular device for cell migration.
Binaural Source Localization by Joint Estimation of ILD and ITD

In this paper, we propose a binaural source localization method based on interaural time differences (ITDs) and interaural level differences (ILDs). The two cues, computed from a two-channel time-frequency representation, are combined in order to estimate the azimuth of sources in binaural recording. We introduce an individual parametric model for the ITD and ILD, and an average parametric model that sets us free from measurements of the subjects' HRIRs for sound localization. We conduct several experiments to validate the proposed approach and show that it compares favorably with available techniques.
Complete Atrioventricular Block due to Infective Endocarditis of Bicuspid Aortic Valve

A 38-year-old man visited our emergency department presenting with a 6-day persistent fever. The man had undergone an orthodontic procedure 7 days prior to the visit. He had a fever with a temperature of 38.2℃ and a diastolic murmur (grade III) was detected at the left sternal border. Reddish-brown lines beneath the nails were present, and raised lesions which were red and painful were detected on the soles of the patient's feet. Laboratory findings showed an elevated inflammatory marker. Transthoracic and transesophageal echocardiograms, showed a bicuspid aortic valve, and moderate aortic regurgitation and vegetation were noted. Treatment with antibiotics was given, but 4 days later, a 12 lead electrocardiogram revealed complete atrioventricular (AV) block. Immediately, a temporary pacemaker was inserted, and the following day an aortic valve replacement was performed. Intraoperative findings revealed a fistula around the AV node. He has suffered no subsequent cardiac events during the follow-up.
Intrinsic signals regulate the initial steps of myogenesis in vertebrates

In vertebrates, despite the evidence that extrinsic factors induce myogenesis in naive mesoderm, other experiments argue that the initiation of the myogenic program may take place independent of these factors. To resolve this discrepancy, we have re-addressed this issue, using short-term in vivo microsurgery and culture experiments in chick. Our results show that the initial expression of the muscle-specific markers Myf5 and MyoD is regulated in a mesoderm-autonomous fashion. The reception of a Wnt signal is required for MyoD, but not Myf5 expression; however, we show that the source of the Wnt signal is intrinsic to the mesoderm. Gain- and loss-of-function experiments indicate that Wnt5b, which is expressed in the presomitic mesoderm, represents the MyoD-activating cue. Despite Wnt5b expression in the presomitic mesoderm, MyoD is not expressed in this tissue: our experiments demonstrate that this is due to a Bmp inhibitory signal that prevents the premature expression of MyoD before somites form. Our results indicate that myogenesis is a multistep process which is initiated prior to somite formation in a mesoderm-autonomous fashion; as somites form, influences from adjacent tissues are likely to be required for maintenance and patterning of early muscles.
Parameter Estimation in a Pulsatile Hormone Secretion Model

This paper presents an algorithm to estimate parameters of a mathematical model of a bipartite endocrine axis. Secretion of one of the involved hormones is stimulated by the concentration of another one, called release hormone, with the latter secreted in a pulsatile manner. The hormone mechanism in question appears often in animal and human endocrine systems, i.e. in the regulation of testosterone in the human male. The model has been introduced elsewhere and enables the application of the theory of pulse-modulated feedback control systems to analysis of pulsatile endocrine regulation. The state-of-the art methods for hormone secretion analysis could not be applied here due to different modeling approach. Based on the mathematical machinery of constrained nonlinear least squares minimization, a parameter estimation algorithm is proposed and shown to perform well on actual biological data yielding accurate fitting of luteinizing hormone concentration profiles. The performance of the algorithm is compared with that of state-of-the art techniques and appears to be good especially in case of undersampled data.
Disease Modeling via Large-Scale Network Analysis Report Title

Disease Modeling via Large-Scale Network Analysis Report Title A central goal of genetics is to learn how the genotype of an organism determines its phenotype. We address the implicit problem of predicting the association of genes with phenotypes or traits. Our primary goal is to develop pragmatic data analytic methods for linking specific genes to traits and diseases, especially polygenic traits, which are the most challenging. We are also interested in developing theoretical guarantees for the methods. In the past, we have developed predictive methods general enough to apply to potentially any genetic trait, varying from plant traits relevant to desirable agricultural properties to important human diseases. Our methods, Katz on heterogeneous network and CATAPULT[1], for predicting gene-disease associations were published during the last project period in the PLOS One journal. The biological problem has also led us to pursue a significant problem in machine learning. One of the fundamental questions in machine learning relating to the classification problem is if we can efficiently learn classifiers that can provably achieve low misclassification rates in the presence of certain type of random label noise in the training data. We have answered the question in affirmative in our recent paper[2], and in particular, developed important theoretical results and robust algorithms for dealing with random label noise in classification. Our CATAPULT system employs "biased" support vector machines (SVM), to cope with the lack of negative examples. Biased SVMs have been empirically shown to be successful for similar tasks, but there has not been any theoretical study previously. In the last project period, we were able to show that they exhibit a certain noise tolerance property, a novel result in machine learning. We have also developed a novel matrix-completion method called Inductive Matrix Completion to the problem of predicting genedisease associations [3] that combines multiple types of features for diseases and genes for discovering new gene–disease associations. While the primary objective is the biological problem, the mathematical models and techniques developed for the problem are expected to shed light on some open problems related to PU(Positive-Unlabeled) learning, such as (a) multiple sources in PU learning, (b) multi-task PU learning, and (c) theoretical guarantees for PU learning algorithms. (a) Papers published in peer-reviewed journals (N/A for none) Enter List of papers submitted or published that acknowledge ARO support from the start of the project to the date of this printing. List the papers, including journal references, in the following categories:
Scenario reduction techniques and solution stability for stochastic unit commitment problems

In power systems rife with uncertainty, stochastic unit commitment (SUC) models may be used to properly size and allocate operational reserves, in order to ensure a reliable and cost-efficient operation of the power system. The performance of SUC-based unit commitment schedules is however fully dependent on the scenario sets used to describe the uncertainty at hand. Dedicated scenario generation & reduction techniques (SGT & SRT) have been developed to generate and select scenario sets that capture the uncertain parameter, e.g. wind power, and yield a cost-optimal unit commitment (UC) schedule in reasonable computing times. Probability-distance based SRTs are by far the most used. In an extensive numerical study, we analyze the performance of so-called cost functions used in these SRTs. In addition, we propose a new cost function, which allows selecting a well-balanced subset of scenarios, resulting in a tractable SUC model and a cost-optimal UC schedule.
What Should a Theory of Vision Look Like?

This paper argues for two major revisions in the way philosophers standardly think of vision science and vision theories more generally. The first concerns mental representations and the second supervenience. The central result is that the way is cleared for an externalist theory of perception. The framework for such a theory has what are called Aristotelian representations as elements in processes the well-functioning of which is the principal object of a theory of vision.
Mediating Effect between Supportive Culture and Job Satisfaction in Administrative Services at Higher Education Institutions

The purpose of this article is to examine halo effect and organizational commitment in relation to employees' job satisfaction and organizational supportive culture at universities in Taiwan. The study used a questionnaire to collect data from 210 female faculty members of Taiwanese universities. The conceptual model was tested mediating the effect of structural equation modeling with maximum likelihood estimation. This study not only found the mediating role of halo effect and organizational commitment between supportive culture and job satisfaction, but also proved that a supportive culture in universities is directly and positively related to job satisfaction and that emotional and identification‐oriented organizational commitment may affect job satisfaction in a positive way among female faculty members. © 2012 Wiley Periodicals, Inc.
Identification and characterization of the furfural and 5-(hydroxymethyl)furfural degradation pathways of Cupriavidus basilensis HMF14

The toxic fermentation inhibitors in lignocellulosic hydrolysates pose significant problems for the production of second-generation biofuels and biochemicals. Among these inhibitors, 5-(hydroxymethyl)furfural (HMF) and furfural are specifically notorious. In this study, we describe the complete molecular identification and characterization of the pathway by which Cupriavidus basilensis HMF14 metabolizes HMF and furfural. The identification of this pathway enabled the construction of an HMF and furfural-metabolizing Pseudomonas putida. The genetic information obtained furthermore enabled us to predict the HMF and furfural degrading capabilities of sequenced bacterial species that had not previously been connected to furanic aldehyde metabolism. These results pave the way for in situ detoxification of lignocellulosic hydrolysates, which is a major step toward improved efficiency of utilization of lignocellulosic feedstock.
Cardiovascular risk factor trends and potential for reducing coronary heart disease mortality in the United States of America.

OBJECTIVE To examine the potential for reducing cardiovascular risk factors in the United States of America enough to cause age-adjusted coronary heart disease (CHD) mortality rates to drop by 20% (from 2000 baseline figures) by 2010, as targeted under the Healthy People 2010 initiative. METHODS Using a previously validated, comprehensive CHD mortality model known as IMPACT that integrates trends in all the major cardiovascular risk factors, stratified by age and sex, we calculated how much CHD mortality would drop between 2000 and 2010 in the projected population of the United States aged 25-84 years (198 million). We did this for three assumed scenarios: (i) if recent risk factor trends were to continue to 2010; (ii) success in reaching all the Healthy People 2010 risk factor targets, and (iii) further drops in risk factors, to the levels already seen in the low-risk stratum. FINDINGS If age-adjusted CHD mortality rates observed in 2000 remained unchanged, some 388,000 CHD deaths would occur in 2010. First scenario: if recent risk factor trends continued to 2010, there would be approximately 19,000 fewer deaths than in 2000. Although improved total cholesterol, lowered blood pressure in men, decreased smoking and increased physical activity would account for some 51,000 fewer deaths, these would be offset by approximately 32,000 additional deaths from adverse trends in obesity and diabetes and in blood pressure in women. Second scenario: If Healthy People 2010 cardiovascular risk factor targets were reached, approximately 188,000 CHD deaths would be prevented. Scenario three: If the cardiovascular risk levels of the low-risk stratum were reached, approximately 372,000 CHD deaths would be prevented. CONCLUSION Achievement of the Healthy People 2010 cardiovascular risk factor targets would almost halve the predicted CHD death rates. Additional reductions in major risk factors could prevent or postpone substantially more deaths from CHD.
The Formation of Group Affect and Team Effectiveness: The Moderating Role of Identification

In the current research we use the social identity perspective to enhance our understanding of group affect (i.e. a collectively shared pattern of affective states among group members). Because higher identification (i.e. the extent to which group members define themselves in terms of their group membership) is related to higher attentiveness to fellow group members, we expected that group identification would foster affective convergence, and that the effects of group affective tone on team effectiveness would be stronger for higher identifying groups. A survey of teams (n=71 teams) confirmed our expectations. A scenario experiment (n=121 participants) added to our findings by showing that identification does indeed lead group members to affectively converge to their fellow group members and that this affective convergence, in turn, explains subsequent team-oriented attitudes. Our study testifies to the notion that team managers may want to take notice of and manage affect in work groups, because, especially in higher identifying teams, affect may spread among team members and influence the team's effectiveness.
Semantic and Phonemic Listener Confusions in a Case of Isolated Congenital Aglossia

This article is the second in a series that examines the intelligibility of a person with congenital aglossia (PWCA). Specific factors examined in this study included (a) intelligibility for meaningful words versus nonsense words, (b) intelligibility for consonant-vowel-consonant words (CVCs) as a function of phonemic segment types, and (c) whether there is a correlation between intelligibility for these factors and the acoustic properties of the speech samples. Results revealed greater intelligibility for meaningful versus nonsense CVCs, greater intelligibility for back, low, and high-back versus front vowels embedded in CVCs, and greater intelligibility for productions as a function of phonemic variables, which demonstrated the following hierarchy: initial consonant > consonant vowel > vowel consonant > final consonant. Further results suggest that consonant recognition was consistently affected by “vowel context. ” This suggests that movement sequencing appeared to be of importance for speech perception in productions of a PWCA.
Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations

Objective. To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. Methods. We first individually analyzed 5 clinical studies, averaging the total iron deficit across all patients utilizing a modified Ganzoni formula; we then similarly analyzed 2 larger clinical studies. For the second of the larger studies (Study 7), we also compared the efficacy and retreatment requirements of a cumulative dose of 1500 mg ferric carboxymaltose (FCM) to 1000 mg iron sucrose (IS). Results. The average iron deficit was calculated to be 1531 mg for patients in Studies 1–5 and 1392 mg for patients in Studies 6-7. The percentage of patients who were retreated with IV iron between Days 56 and 90 was significantly (p < 0.001) lower (5.6%) in the 1500 mg group, compared to the 1000 mg group (11.1%). Conclusions. Our data suggests that a total cumulative dose of 1000 mg of IV iron may be insufficient for iron repletion in a majority of patients with IDA and a dose of 1500 mg is closer to the actual iron deficit in these patients.
Understanding why the justice of group procedures matters: A test of the psychological dynamics of the group-value model.

Procedural justice research has documented many positive consequences of fair decision-making procedures and treatment by authorities. However, it is unclear why these effects of procedural justice occur. The group-value model proposes that fair procedures matter because they communicate two symbolic messages about group membership:(a) whether individuals are respected members of a group and (b) whether they should feel pride in the group as a whole. These messages are conveyed by 3 relational aspects ofthe actions ofauthorities-actions that indicate neutrality, trustworthiness, and status recognition. Results from 4 different studies provide evidence that:(a) relational aspects of fair procedures communicate group-relevant information, and (b) this information mediates the influence of procedural judgments on group-oriented behaviors and feelings of self-esteem.
Sustainable Housing Development in Urban Australia: exploring obstacles to and opportunities for ecocity efforts

Abstract Basic aspects of sustainable housing design such as increasing density, mixed use and proximity to public transport are being adopted increasingly in Australian cities. Sustainable building codes such as NSW's BASIX and Victoria's Green Star rating systems are also being implemented and advanced. More substantial improvements and endeavours such as onsite food production, energy generation and waste treatment, are being seen increasingly as necessary for urban sustainability, yet little is being done to institutionalise or normalise these through Australia's housing system. Similarly, concerns about the social sustainability of housing identify the need for mixed, flexible tenure and dwelling types, with again little uptake despite evidence of demand. Given that we seem to know what needs doing to move towards sustainability, this paper investigates two ecologically and socially sound community-based housing developments in Australia, with a view to finding what helped or hindered these efforts and what may further the uptake of sustainable design. Assessment of the uptake of sustainable planning initiatives reveals the prevalence of a decidedly neoliberal agenda which shies away from the more substantial challenges ecocity design and community-based enterprise may represent. Such community-based initiatives must, however, be supported at a broader scale, to avoid possible outsourcing of governmental responsibility or the relegation of sustainable design to the sole realm of the wealthy.
Don’t Call Me NIMBY

With an ever-expanding stream of solid waste, and limited possibilities for disposal, communities increasingly have to make difficult decisions about where to store these by-products of daily living. The authors use survey data from seven counties in Florida that have recently dealt with solid waste location decisions to assess the extent to which citizen attitudes reflect a NIMBY perspective to these facilities. Contrary to what the NIMBY phenomena predicts, respondents who lived closer to existing or proposed facilities were not more likely to perceive them as dangerous as those living further away. In addition, the respondents were able to list problems and benefits to support their perceptions of danger posed by these facilities. These findings suggest that citizens do not always respond to environmental risks by gut reaction or without information as is sometimes suggested in the NIMBY literature.