Miracle-dz/UniFAR-FTUs huggingface dataset:
A Mobile Platform for Wireless Charging and Data Collection in Sensor Networks

Wireless energy transfer (WET) is a new technology that can be used to charge the batteries of sensor nodes without wires. Although wireless, WET does require a charging station to be brought to within reasonable range of a sensor node so that a good energy transfer efficiency can be achieved. On the other hand, it has been well recognized that data collection with a mobile base station has significant advantages over a static one. Given that a mobile platform is required for WET, a natural approach is to employ the same mobile platform to carry the base station for data collection. In this paper, we study the interesting problem of co-locating a wireless charger (for WET) and a mobile base station on the same mobile platform-the wireless charging vehicle (WCV). The WCV travels along a pre-planned path inside the sensor network. Our goal is to minimize energy consumption of the entire system while ensuring that 1) each sensor node is charged in time so that it will never run out of energy, and 2) all data collected from the sensor nodes are relayed to the mobile base station. We develop a mathematical model for this problem (OPT-t), which is time-dependent. Instead of solving OPT-t directly, we show that it is sufficient to study a special subproblem (OPT-s) which only involves space-dependent variables. Subsequently, we develop a provably near-optimal solution to OPT-s. Our results offer a solution on how to use a single mobile platform to address both WET and data collection in sensor networks.
valuating the impacts of crop rotations on groundwater storage and echarge in an agricultural watershed bdullah

The Mississippi River Valley Alluvial Aquifer, which underlies the Big Sunflower River Watershed (BSRW), is the most heavily used aquifer in Mississippi. Because the aquifer is primarily used for irrigating crops such as corn, cotton, soybean, and rice, the water levels have been declining rapidly over the past few decades. The objectives of this study are to analyze the relationship and interactions between evapotranspiration and groundwater recharge rates in the BSRW, and model the effects of various crop rotation practices on groundwater storage and recharge. The model performed well during the calibration period (R2 = 0.53–0.68 and NSE = 0.49–0.66) and validation period (R2 = 0.55–0.75 and NSE = 0.49–0.72) for daily streamflow, which was achieved by the SUFI-2 auto-calibration algorithm in the SWAT-CUP package. The model also performed well in simulating seasonal water table depth fluctuations during calibration (R2 = 0.76 and NSE = 0.71) and validation (R2 = 0.86 and NSE = 0.79). This study demonstrated a seasonal relationship between evapotranspiration and groundwater storage and recharge in the BSRW SWAT model. In general, groundwater storage decreased during the summer months while ET rates were high, and increased during the winter and spring months when ET rates were low. The crop rotation scenarios that include rice planting resulted in the lowest groundwater storage (down to −10.7%) compared to the baseline crop scenario, which is due to the high irrigation rates of the rice crop. However, the rice crop rotations resulted in the highest increases of groundwater recharge rates (up to +60.1%), likely because of the response to the deficiency of groundwater needed for irrigation as well as the limited water uptake by the rice crop. The crop rotations with corn and cotton resulted in the largest increases in groundwater storage (up to +27.2%), which is the result of the low irrigation rates as well as the short time period for irrigation applications. The results of this study are expected to aid farmers and watershed managers to conserve groundwater resources, but still maintain crop production. © 2015 Elsevier B.V. All rights reserved.
Competence in the context of adversity: Pathways to resilience and maladaptation from childhood to late adolescence

Competent outcomes in late adolescence were examined in relation to adversity over time, antecedent competence and psychosocial resources, in order to investigate the phenomenon of resilience. An urban community sample of 205 (114 females, 90 males; 27% minority) children were recruited in elementary school and followed over 10 years. Multiple methods and informants were utilized to assess three major domains of competence from childhood through adolescence (academic achievement, conduct, and peer social competence), multiple aspects of adversity, and major psychosocial resources. Both variable-centered and person-centered analyses were conducted to test the hypothesized significance of resources for resilience. Better intellectual functioning and parenting resources were associated with good outcomes across competence domains, even in the context of severe, chronic adversity. IQ and parenting appeared to have a specific protective role with respect to antisocial behavior. Resilient adolescents (high adversity, adequate competence across three domains) had much in common with their low-adversity competent peers, including average or better IQ, parenting, and psychological well-being. Resilient individuals differed markedly from their high adversity, maladaptive peers who had few resources and high negative emotionality. Results suggest that IQ and parenting scores are markers of fundamental adaptational systems that protect child development in the context of severe adversity.
Genome-wide identification of lineage and locus specific variation associated with pneumococcal carriage duration

Streptococcus pneumoniae is a leading cause of invasive disease in infants, especially in low-income settings. Asymptomatic carriage in the nasopharynx is a prerequisite for disease, and the duration of carriage is an important consideration in modelling transmission dynamics and vaccine response. Existing studies of carriage duration variability are based at the serotype level only, and do not probe variation within lineages or fully quantify interactions with other environmental factors. Here we developed a model to calculate the duration of carriage episodes from longitudinal swab data. By combining these results with whole genome sequence data we estimate that pneumococcal genomic variation accounted for 63% of the phenotype variation, whereas host traits accounted for less than 5%. We further partitioned this heritability into both lineage and locus effects, and quantified the amount attributable to the largest sources of variation in carriage duration: serotype (17%), drug-resistance (9%) and other significant locus effects (7%). For the locus effects, a genome-wide association study identified 16 loci which may have an effect on carriage duration independent of serotype. Hits at a genome-wide level of significance were to prophage sequences, suggesting infection by such viruses substantially affects carriage duration. These results show that both serotype and non-serotype specific effects alter carriage duration in infants and young children and are more important than other environmental factors such as host genetics. This has implications for models of pneumococcal competition and antibiotic resistance, and leads the way for the analysis of heritability of complex bacterial traits. Significance statement Other than serotype, the genetic determinants of pneumococcal carriage duration are unknown. In this study we used longitudinal sampling to measure the duration of carriage in infants, and searched for any associated variation in the pan-genome. While we found that the pathogen genome explains most of the variability in duration, serotype did not fully account for this. Recent theoretical work has proposed the existence of alleles which alter carriage duration to explain the puzzle of continued coexistence of antibiotic-resistant and sensitive strains. Here we have shown that these alleles do exist in a natural population, and also identified candidates for the loci which fulfil this role. Together these findings have implications for future modelling of pneumococcal epidemiology and resistance.
Recurrent Neural Network for Non-Smooth Convex Optimization Problems With Application to the Identification of Genetic Regulatory Networks

A recurrent neural network is proposed for solving the non-smooth convex optimization problem with the convex inequality and linear equality constraints. Since the objective function and inequality constraints may not be smooth, the Clarke's generalized gradients of the objective function and inequality constraints are employed to describe the dynamics of the proposed neural network. It is proved that the equilibrium point set of the proposed neural network is equivalent to the optimal solution of the original optimization problem by using the Lagrangian saddle-point theorem. Under weak conditions, the proposed neural network is proved to be stable, and the state of the neural network is convergent to one of its equilibrium points. Compared with the existing neural network models for non-smooth optimization problems, the proposed neural network can deal with a larger class of constraints and is not based on the penalty method. Finally, the proposed neural network is used to solve the identification problem of genetic regulatory networks, which can be transformed into a non-smooth convex optimization problem. The simulation results show the satisfactory identification accuracy, which demonstrates the effectiveness and efficiency of the proposed approach.
Medication use in adults with attention deficit/hyperactivity disorder in a commercially-insured population in the United States

Abstract Objective: To examine real-world prescription medication usage among commercially-insured adults with attention deficit/hyperactivity disorder (ADHD) in the US. Methods: Adults with ADHD who received ≥1 ADHD medication during 2013 were identified from a large US claims database. Combination therapy was defined as an overlap of ≥30 days between the index (first treatment ≥30 days in 2013) and another medication(s). Patients were classified into six groups: long-acting (LA) monotherapy, short-acting (SA) monotherapy, LA + LA, SA + SA, LA + SA, and >2 therapies. Analyses compared baseline characteristics by regimen, ranked combination regimens, and estimated daily average consumption (DACON) for monotherapy users. Results: Of 206,443 adults with ADHD (mean age = 32.9 years; 51.6% female), 56.9% used LA monotherapy, 30.7% SA monotherapy, and 12.5% used combination therapies (LA + SA: 10.3%; LA + LA: 1.3%; SA + SA: 0.4%; >2 therapies: 0.5%). Extended-release mixed amphetamine salts (MAS-XR, 39.2%) and lisdexamfetamine (LDX, 31.5%) were the most common LA monotherapies. Nearly all SA monotherapy patients received immediate-release mixed amphetamine salts (MAS-IR; 81.7%). The top three therapies among combination categories were: (a) LA + LA: branded MAS-XR + generic MAS-XR (13.7%), LDX + generic MAS-XR (10.8%), LDX + guanfacine ER (10.7%); (b) SA + SA: generic MAS-IR + clonidine IR (33.5%), generic MAS-IR + generic MPH SA (17.9%), branded MAS-IR + generic MAS-IR (11.1%); (c) LA + SA: generic MAS-XR+/-IR (39.2%), LDX + generic MAS-IR (16.7%), LA + SA generic MPH (12.6%). Among monotherapy users, DACON was 1.2 ± 0.6 (LA) and 2.1 ± 0.9 (SA) tablets. Conclusions: There is significant treatment heterogeneity among US adults with ADHD. A sizable proportion of patients received monotherapies at above the recommended dosages or combination therapies, suggesting existing single-tablet regimens may not meet patients’ needs.
Ocular Drug Delivery Barriers—Role of Nanocarriers in the Treatment of Anterior Segment Ocular Diseases

Ocular drug delivery is challenging due to the presence of anatomical and physiological barriers. These barriers can affect drug entry into the eye following multiple routes of administration (e.g., topical, systemic, and injectable). Topical administration in the form of eye drops is preferred for treating anterior segment diseases, as it is convenient and provides local delivery of drugs. Major concerns with topical delivery include poor drug absorption and low bioavailability. To improve the bioavailability of topically administered drugs, novel drug delivery systems are being investigated. Nanocarrier delivery systems demonstrate enhanced drug permeation and prolonged drug release. This review provides an overview of ocular barriers to anterior segment delivery, along with ways to overcome these barriers using nanocarrier systems. The disposition of nanocarriers following topical administration, their safety, toxicity and clinical trials involving nanocarrier systems are also discussed.
Modulation of neural circuits underlying temporal production by facial expressions of pain

According to the Scalar Expectancy Theory, humans are equipped with a biological internal clock, possibly modulated by attention and arousal. Both emotions and pain are arousing and can absorb attentional resources, thus causing distortions of temporal perception. The aims of the present single-event fMRI study were to investigate: a) whether observation of facial expressions of pain interferes with time production; and b) the neural network subserving this kind of temporal distortions. Thirty healthy volunteers took part in the study. Subjects were asked to perform a temporal production task and a concurrent gender discrimination task, while viewing faces of unknown people with either pain-related or neutral expressions. Behavioural data showed temporal underestimation (i.e., longer produced intervals) during implicit pain expression processing; this was accompanied by increased activity of right middle temporal gyrus, a region known to be active during the perception of emotional and painful faces. Psycho-Physiological Interaction analyses showed that: 1) the activity of middle temporal gyrus was positively related to that of areas previously reported to play a role in timing: left primary motor cortex, middle cingulate cortex, supplementary motor area, right anterior insula, inferior frontal gyrus, bilateral cerebellum and basal ganglia; 2) the functional connectivity of supplementary motor area with several frontal regions, anterior cingulate cortex and right angular gyrus was correlated to the produced interval during painful expression processing. Our data support the hypothesis that observing emotional expressions distorts subjective time perception through the interaction of the neural network subserving processing of facial expressions with the brain network involved in timing. Within this frame, middle temporal gyrus appears to be the key region of the interplay between the two neural systems.
Fundamental Actuation Properties of Multirotors: Force–Moment Decoupling and Fail–Safe Robustness

In this paper, we shed light on two fundamental actuation capabilities of multirotors. The first is the degree of coupling between the total force and total moment generated by the propellers. The second is the ability to robustly fly completely still in place after the loss of one or more propellers, in the case of mono-directional propellers. These are formalized through the definition of some algebraic conditions on the control allocation matrices. The theory is valid for any multirotor, with arbitrary number, position, and orientation of the propellers. As a show case for the general theory, we demonstrate that standard star-shaped hexarotors with collinear propellers are not able to robustly fly completely still at a constant spot using only five of their six propellers. To deeply understand this counterintuitive result, it is enough to apply our theory, which clarifies the role of the tilt angles and locations of the propellers. The theory is also able to explain why, on the contrary, both the tilted star-shaped and the Y-shaped hexarotors can fly with only five out of six propellers. The analysis is validated with both simulations and extensive experimental results showing recovery control after rotor losses.
A Two-Stage Model for User's Examination Behavior in Mobile Search

With the rapid growth of mobile search, it is important to understand how users browse the mobile SERPs and allocate their limited attention to each result. To address this problem, we introduce a two-stage examination model that can separately capture the position bias with a skimming model and the attractiveness bias with an attractiveness model. The effectiveness of the proposed model is validated by using a dataset that contains explicit examination feedbacks from users. We further investigate user»s examination behaviors by analyzing the model parameters learned via EM algorithm. The results reveal some interesting findings such as how the skimming behavior is dependent on the previous examination sequence and what factors are associated with the attractiveness of search results on mobile SERPs.
The essential nature of glycine and proline for growing chickens.

Abstract Four assays were conducted to ascertain the influence of age, length of feeding period and prior dietary regimen on the essentiality of glycine and proline for growing chickens. It was observed that both glycine (in the absence of dietary serine) and proline were essential for maximal performance at all stages of life between hatching and eight weeks post-hatching. The growing chicken appears capable, however, of synthesizing roughly 90% of its proline and 60–70% of its glycine need for maximal growth.
CREx: inferring genomic rearrangements based on common intervals

SUMMARY We present the web-based program CREx for heuristically determining pairwise rearrangement events in unichromosomal genomes. CREx considers transpositions, reverse transpositions, reversals and tandem-duplication-random-loss (TDRL) events. It supports the user in finding parsimonious rearrangement scenarios given a phylogenetic hypothesis. CREx is based on common intervals, which reflect genes that appear consecutively in several of the input gene orders. AVAILABILITY CREx is freely available at http://pacosy.informatik. uni-leipzig.de/crex
The clinical and laboratory features of neurosyphilis in HIV-infected patients

Abstract Neurosyphilis (NS) is an important component of central nervous system diseases among HIV-infected patients. However, its characteristics are not very clear. A retrospective analysis of clinical and laboratory findings was performed in 92 NS patients with HIV infection from a tertiary hospital in Shanghai, China. The patients had a median age of 38 years and a median CD4 count of 198 cells/&mgr;L. In all, 44.6% (41/92) were diagnosed as asymptomatic NS (ANS), 23.9% (22/92) as syphilitic meningitis, 17.4% (16/92) as cerebrovascular NS, and 14.1% (13/92) as parenchymal syphilis. A quarter of patients (23/92) complicated with ocular syphilis (OS), 60.9% (14/23) of which were ANS. The serum tolulized red unheated serum test (TRUST) titers were ⩽1:8 in 15 patients (16.3%), 1:16–1:128 in 51 patients (55.4%), and ≥1:256 in 26 patients (28.3%). Sixty-nine patients (75.0%) had both cerebrospinal fluid (CSF) TRUST and Treponema pallidum particle assay reactive. CSF pleocytosis and protein elevation were found in 58.7% and 53.3% of patients, respectively. Syphilitic meningitis was more likely to present with CSF pleocytosis than ANS (P = .001), cerebrovascular NS (P < .001), and parenchymal NS (P < .001). The proportion of patients with CSF elevated protein was lower in ANS group than that in syphilitic meningitis (P = .003), cerebrovascular NS (P = .001), and parenchymal NS groups (P = .025), and was higher in sero-TRUST titers ⩽1:8 group than that in 1:16–1:128 (P = .01) and 1:256–1:1024 groups (P = .005). This study revealed that ANS was the most common clinical type of NS in HIV-infected patients, which should be considered in HIV and syphilis co-infection patients without neurologic symptoms, especially in those with OS. Different patterns of NS might have different CSF features which may also vary with sero-TRUST titers.
Dietary level of fat, calcium, and vitamins A and D3 as contributory factors to rickets in poults.

Two experiments were conducted on dietary predisposition to rickets in poults. The first experiment compared fat type (corn oil or tallow), level of added fat (3.5 or 7%), vitamin D3 (900 or 2,400 IU/kg feed), and total calcium (.6, 1.2, or 3%) inclusion in the diet. Poults fed diets supplemented with corn oil had higher percentage tibia ash than poults fed tallow-supplemented diets. Vitamin D3 included at 2,400 IU/kg feed increased body weights significantly by 2 and 4 weeks of age and lowered plasma alkaline phosphatase (AP) at 2 and 4 weeks compared with diets containing 900 IU/kg feed. Tibia ash was significantly greater with the higher vitamin D3 supplementation at 2 weeks. At 2 weeks of age both low (.6%) and high (3%) levels of dietary calcium increased plasma AP, decreased tibia ash, and decreased body weight compared with diets containing 1.2% calcium. By 4 weeks of age, diets containing 1.2 and 3% calcium had no significant effects on body weight and plasma AP; however, tibia ash was significantly greater with these levels than with the . 6% calcium diets. The second experiment compared level of dietary tallow inclusion (2.5 or 7%) and supplementary vitamin A (4,000, 16,000, or 44,000 IU/kg feed). The high tallow diets decreased tibia ash at 3 weeks, and the maximum supplementation of vitamin A significantly depressed body weight. Clinical rickets were first noted at 18 days of age. By 26 days of age the higher level of dietary fat and the highest level of vitamin A caused a significant increase in severity of rickets. The results suggested that rickets can be induced by high dietary levels of tallow and vitamin A.
Reactive oxygen species‐induced parthanatos of immunocytes by human cytomegalovirus‐associated substance

Previous studies have examined various immune evasion strategies of human cytomegalovirus (HCMV) to gain understanding of its pathogenesis. Although the mechanism that underlies immunocyte destruction near HCMV‐infected lesions has yet to be established, it is here shown that substances produced by HCMV‐infected cells induce death in several types of immunocytes, but not in fibroblasts or astrocytomas. These substances contain HCMV proteins and were termed HCMV‐associated insoluble substance (HCMVAIS). The mechanism by which HCMVAIS induces cell death was characterized to improve understanding the death of immunocytes near HCMV‐infected lesions. HCMVAIS were found to trigger production of intracellular nicotinamide adenine dinucleotide phosphate oxidase‐derived reactive oxygen species (ROS), resulting in cell death, this effect being reversed following treatment with ROS inhibitors. Cell death was not induced in splenocytes from NOX‐2 knockout mice. It was hypothesized that DNA damage induced by oxidative stress initiates poly ADP‐ribose polymerase‐1 (PARP‐1)‐mediated cell death, or parthanatos. HCMVAIS‐induced cell death is accompanied by PARP‐1 activation in a caspase‐independent manner, nuclear translocation of apoptosis‐inducing factor (AIF), and DNA fragmentation, which are typical features of parthanatos. Treatment with an AIF inhibitor decreased the rate of HCMVAIS‐induced cell death, this being confirmed by hematoxylin and eosin staining; cell death in most HCMV‐positive foci in serial section samples of a large intestine with HCMV infection was TUNEL‐positive, cleaved caspase 3‐negative and CD45‐positive. Taken together, these data suggest that HCMV inhibits local immune responses via direct killing of immunocytes near HCMV‐infected cells through ROS‐induced parthanatos by HCMVAIS.