Miracle-dz/UniFAR-FTUs huggingface dataset:
BUILDING THE POM CURRICULUM FOR A PRIVATIZING ECONOMY: AN EVALUATION FROM MANUFACTURERS‘ PERSPECTIVES

Manufacturing in Eastern European countries is in transition to open‐market competition. One transitional issue is university education for operations managers from the perspective of business practitioners. Survey responses by 203 manufacturing professionals from 83 companies provide recommendations for operations management education at the University of Sibiu in Romania. The recommendations substantially reorient curricula that traditionally prepared students for professions in centrally controlled economies rather than for open‐market competition. The redesigned curriculum has an educational advantage in its integration of production, marketing, and engineering, all under one college of engineering. However, the curriculum is inconsistent with some tenets of quality management and just‐in‐time production. Also, survey data imply a need for coverage of competitive manufacturing strategy that, currently, is underrepresented in the curriculum.
p38&agr; Is Required for Ovarian Cancer Cell Metabolism and Survival

Introduction: Ovarian cancer is highly sensitive to chemotherapy but also shows a high rate of recurrence and drug resistance. These negative outcomes mostly depend on altered apoptotic pathways, making the design of new therapeutic strategies based on the induction of other types of cell death highly desirable. Several lines of research are now addressing cancer-specific features to specifically target tumor cells, thus reducing adverse effects. In this light, a great deal of attention has been devoted to the metabolic reprogramming occurring in cancer cells, which display increased levels of glycolysis compared with their normal counterparts. We recently showed that inhibition of p38&agr; impairs key metabolic functions of colorectal cancer cells, inducing growth arrest, autophagy, and cell death both in vivo and in vitro. These effects are mediated by a switch from hypoxia-inducible factor 1&agr; (HIF1&agr;) to forkhead transcription factor O (FoxO)-dependent transcription. Methods: We first characterized p38 expression in OVCAR-3, A2780, and SKOV-3 ovarian cancer cell lines. Then, we treated these cells with the p38&agr;/p38&bgr;-specific inhibitor SB202190 and performed a morphological, proliferation, and survival analyses. Finally, we studied HIF1&agr; and FoxO3A expressions and signaling pathways to evaluate their role in SB202190-induced effects. Results: p38&agr; blockade induces the formation of intracellular autophagic vacuoles and reduces growth and viability of ovarian cancer cells. As in colorectal cancer, the underlying molecular mechanism seems to rely on a shift from HIF1&agr;- to FoxO3A-dependent transcription, which is promoted by the activation of the adenosine monophosphate-activated protein kinase pathway. Conclusions: These data corroborate the hypothesis that pharmacological modulation of genes involved in cancer-specific homeostasis, such as p38&agr;, might be exploited to design new therapeutic approaches to cancer treatment.
Medial aortic lesions in rats with metacorticoid hypertension.

IT IS ACCEPrED today that the pathologic consequences of human and experimental hypertension are primarily found in the arterioles. Reports of aortic lesions associated with hypertension ' have not found their way into accepted medical thinking. Textbooks of pathology, or even a recent and most comprehensive monograph on hypertension,9 do not mention the reports cited. Yet the subject is obviously important since, as Freis 10 has pointed out, hypertension appears to be the single most important known factor to be influential in the course and even the genesis of atherosclerosis. The present experiment was designed to study the ultrastucture of the aorta in rats with metacorticoid hypertension. " Under the conditions of this experiment, medial as well as intimal lesions were produced. This report concerns itself with an ultrastructural study of the medial lesions.
Resting-State fMRI: A Review of Methods and Clinical Applications

SUMMARY: Resting-state fMRI measures spontaneous low-frequency fluctuations in the BOLD signal to investigate the functional architecture of the brain. Application of this technique has allowed the identification of various RSNs, or spatially distinct areas of the brain that demonstrate synchronous BOLD fluctuations at rest. Various methods exist for analyzing resting-state data, including seed-based approaches, independent component analysis, graph methods, clustering algorithms, neural networks, and pattern classifiers. Clinical applications of resting-state fMRI are at an early stage of development. However, its use in presurgical planning for patients with brain tumor and epilepsy demonstrates early promise, and the technique may have a future role in providing diagnostic and prognostic information for neurologic and psychiatric diseases.
Acceleration of the Median Nerve Distal Latency Time in Preterm Infants with Intrauterine Growth Retardation

Extract: The distal latency time (DLT) of the median nerve was measured in infants at various stages of in utero and ex utero maturation.The DLT measured at 36° (DLT36) during the first 3 days of life was inversely related to gestational age in normal preterm infants. However, the DLT36 was significantly accelerated in infants with in utero growth retardation (IUGR). In normal infants the DLT36 was significantly related to the nerve conduction velocity of the proximal segment of the median nerve. This relation was lost in infants with IUGR, since the DLT36 was accelerated but not the nerve conduction velocity.In normal preterm infants the slope of change of DLT36 in utero with maturation was similar to the change ex utero. With IUGR the DLT36 shortened sharply during the first 2 weeks of postnatal life, and thereafter the DLT36 changed at the same rate as in normal infants.The DLT is sensitive to temperature change in the thenar muscle. The more immature the infant the greater the change of DLT with temperature.Apnea in preterm infants was not significantly related to the DLT36.Speculation: Intrauterine growth retardation accelerates the DLT of the median nerve but not the nerve conduction velocity of the proximal nerve. This study focused only on DLT changes with severe intrauterine growth retardation compared with normal preterm and term infants. Acceleration of the DLT may be a useful index of chronic stress in utero not associated with severe growth retardation.
DIFFERENTIAL EFFECTS OF VASOPRESSINERGIC AND OXYTOCINERGIC PRE‐AUTONOMIC NEURONS ON CIRCULATORY CONTROL: REFLEX MECHANISMS AND CHANGES DURING EXERCISE

1 The role of vasopressinergic and oxytocinergic (VPergic and OTergic, respectively) projections to the brain stem in the modulation of heart rate control is discussed on the basis of both changes in the peptide content of the dorsal brain stem (DBS) and functional effects following reflex‐ and exercise‐induced activation in the presence and/or absence of receptor blockade within the nucleus tractus solitarius (NTS) and/or peripheral autonomic block. 2 Experimental data showed a dual effect of NTS VPergic projections on reflex control: (i) to maintain tonically the reflex sensitivity; and (ii) to reset reflex bradycardia towards higher heart rate values when transiently activated. The VPergic drive causes less sympathetic inhibition during pressure increases, mainly by reducing peripheral information going to NTS second‐order neurons. Treadmill running increases the vasopressin content within the DBS. This activates NTS V1 receptors to cause a significant improvement of exercise tachycardia in both sedentary and trained rats. 3 The OTergic drive to DBS areas (NTS/dorsal motor nucleus of the vagus) is also tonic for baroreceptor reflex control: it improves reflex bradycardia by facilitating vagal outflow to the heart. An acute bout of exercise increases DBS oxytocin (OT) content in trained rats, causing a significant blunting of exercise tachycardia only in this group. In both sedentary and trained groups, basal heart rate varies inversely with DBS OT content, the resting bradycardia of trained rats being associated with higher OT content. 4 Specific coordinated activation of VPergic and OTergic suprabulbar pathways is essential to adjust heart rate and cardiac output to circulatory demand at rest and during exercise in both sedentary and trained individuals.
Horizontalists and Verticalists: The Macroeconomics of Credit Money

Preface Acknowledgments Part I. The Endogeneity of Credit Money: 1. The differences between commodity, fiat, and credit money 2. Contemporary commercial banking 3. A simple model of bank intermediation 4. The money 'multiplier' 5. The endogeneity of the high-powered base 6. The US money supply process 7. A causality analysis of the determinants of money growth 8. Keynes and the endogeneity of credit money Part II. The Macroeconomic Implications of Monetary Endogeneity: 9. The determination of the nominal money supply 10. Interest rates: a real or monetary phenomenon? 11. Interest rates: an exogenous policy variable 12. Monetary change, deficit spending, and the growth of aggregate demand 13. The determination of the real money supply 14. Inflation and velocity 15. the dynamics of disequilibrium: toward a new macroeconomic paradigm Bibliography Index.
Getting Credit to High Return Microentrepreneurs

Small-scale entrepreneurs typically cite access to finance as the most important constraint to growth. Recent randomized experiments have shown the return to capital to be very high for the average microenterprise in Sri Lanka. An intervention was designed to improve access to credit among these high-return microenterprises without subsidizing interest rates or requiring group lending. The intervention consisted of information sessions providing details of the microfinance loan product offered by a regional development bank and a reduction from two to one in the number of personal guarantors required for these loans. Ten percent of the microenterprises invited to the information meetings received a new loan, doubling the proportion of firms receiving loans over this period. However, the loans do not appear to be going to particularly high-return firms but rather to firms with more household assets. Many more firms would like loans but are constrained by an inability to find personal guarantors and by othe.
Complete Genome Sequence of Pusillimonas sp. T7-7, a Cold-Tolerant Diesel Oil-Degrading Bacterium Isolated from the Bohai Sea in China

ABSTRACT Pusillimonas sp. T7-7 is a diesel oil-degrading cold-tolerant bacterium isolated from the benthal mud of a petroleum-contaminated site in Bohai Sea, China. We present here the complete genome sequence of T7-7. Genome analysis revealed many features of typical marine bacteria, including the absence of intact sugar metabolic pathways, the presence of glyoxylate and gluconeogenesis pathways, and the abilities for nitrate assimilation and denitrification, as well as sulfate reduction and sulfite oxidation. The presence of novel genes for the degradation of diesel oils was suggested.
The Value Relevance of Accounting Numbers Under International Financial Reporting Standards

type="main"> We study the market reaction to the mandatory adoption of International Financial Reporting Standards (IFRS) in Spain by examining the value relevance of the information contained in the IFRS reconciliation adjustments in relation to the local generally accepted accounting principles (GAAP). The two-staged IFRS disclosure in the transition period is specific to Spain: the aggregated numbers of accounting differences are disclosed in stage 1, and the IFRS individual adjustments on book value of equity and earnings are disclosed in stage 2. This unique reporting timeline provides an opportunity for the market both to assess the impact of those new accounting policies adopted by firms and to assess differences when compared to the previous GAAP. We find no evidence of increased value relevance after IFRS adoption. However, our results from the incremental value relevance test show that investors consider the individual reconciliation adjustments in the second stage to be valuable and significant, specifically in relation to marked-to-market adjustment to financial instruments, adjustments to intangibles, provisions and impairment adjustments to property, plant and equipment, adjustments to inventories, and adjustments to pension benefits. Moreover, the results are significantly higher for low leverage firms. Our findings indicate that the market prices the informativeness of the reconciliation adjustments once the transition to IFRS disclosure cycle is complete.
Food, place and authenticity: local food and the sustainable tourism experience

In recent years, attempts to improve the economic and environmental sustainability of both tourism and agriculture have been linked to the development of “alternative” food networks and a renewed enthusiasm for food products that are perceived to be traditional and local. This paper draws on research from two UK regions, the Lake District and Exmoor, to argue that local food can play an important role in the sustainable tourism experience because it appeals to the visitor's desire for authenticity within the holiday experience. Using evidence from qualitative interviews with tourists and food producers, the paper records ways in which local foods are conceptualised as “authentic” products that symbolise the place and culture of the destination. By engaging with debates surrounding the meaning of locality and authenticity, the paper challenges existing understandings of these concepts and offers a new way forward for tourism research by arguing that “local food” has the potential to enhance the visitor experience by connecting consumers to the region and its perceived culture and heritage.
Some Macroeconomic Implications of Price Stickiness

A simple macro model incorporating a little price stickiness is compared to a basic new-classical model. It is argued that the former system, while still yielding standard policy ineffectiveness results, more easily explains persistence in fluctuations in real variables, notably real balances, without being more complicated. It is also shown that these results do not depend upon the model's analytic simplicity but also occur in a more complex formulation. A sticky-price model therefore should be taken seriously as embodying a viable alternative to new-classical macroeconomics. Copyright 1988 by Blackwell Publishers Ltd and The Victoria University of Manchester
Measuring tourism chain performance

The measurement of a destinations' network performance is a complex task due to the diverse actors involved and their complex relationships and there is a need to find simplified and manageable approaches for evaluation. One approach that is frequently used when a situation is too complex or requires a great amount of analysis is to divide the problem in order to conquer it. In this paper, the tourism chain is used to provide a simplified and manageable performance measurement unit for network efficiency. A tourism chain is a pattern in the way tourists interact with a destination. The purpose of this study is to develop a performance index for a tourism chain utilizing fuzzy set theory. The performance measurement model developed was then used to examine the effectiveness of various management strategies. The study found that the performance measurement system may be included in a management information feedback system to help improve decision making processes and the performance of tourism chains.
Workspace Representation and Optimization of a Novel Parallel Mechanism with Three-Degrees-of-Freedom

The development of a new parallel mechanism based on simulation driven design is a rapid approach to discover the unique features or advantages of a conceptual model. In this research, one novel parallel mechanism which can generate three degrees-of-freedom translations is proposed. The kinematic model and Jacobian matrix is derived. The workspace generation and mapping is investigated based on simplified boundary searching method. The particle swarm algorithm is applied to search for the optimal volume of workspace.
Identification of novel factors involved in or regulating initiation of DNA replication by a genome-wide phenotypic screen in Saccharomyces cerevisiae

DNA replication in eukaryotic cells is tightly regulated to ensure faithful inheritance of the genetic material. While the replicators, replication origins and many replication-initiation proteins in Saccharomyces cerevisiae have been identified and extensively studied, the detailed mechanism that controls the initiation of DNA replication is still not well understood. It is likely that some factors involved in or regulating the initiation of DNA replication have not been discovered. To identify novel DNA replication-initiation proteins and their regulators, we developed a sensitive and comprehensive phenotypic screen by combining several established genetic strategies including plasmid loss assays with plasmids containing a single versus multiple replication origins and colony color sectoring assays. We isolated dozen of mutants in previously known initiation proteins and identified several novel factors, including Ctf1p Ctf3p, Ctf4p, Ctf18p, Adk1p and Cdc60p, whose mutants lose plasmid containing a single replication origin at high rates but lose plasmid carrying multiple replication origins at lower rates. We also show that overexpression of replication initiation proteins causes synthetic dosage lethality or growth defects in ctf1 and ctf18 mutants and that Ctf1p and Ctf18p physically interact with ORC, Cdt1p and MCM proteins. Furthermore, depletion of both Ctf1p and Ctf18p prevents S phase entry, retards S phase progression, and reduces pre-RC formation during the M-to-G1 transition. These data suggest that Ctf1p and Ctf18p together play important roles in regulating the initiation of DNA replication.
Symptom Validity Test Failure Indicates Invalidity of Neuropsychological Tests

Neuropsychological and symptom validity test results from 220 archival cases were analyzed to determine if failing a symptom validity test (SVT) affects the relationship between neuropsychological tests and brain damage. Results reveal that among those who failed either the Word Memory Test (WMT) or the Computerized Test of Attention and Memory (CTAM) there was no correlation between the results of 25 commonly used neuropsychological tests and objectively determined brain damage. For those who passed SVTs, the expected relationship between neuropsychological tests and brain damage was found. Consistent with earlier findings, effort had a greater effect on test performance than did brain damage. SVT performance was not correlated with either brain damage or the presence of external incentives. Results indicate the need for symptom validity testing in all cases and that failure of a single SVT can invalidate the expected brain–behavior relationship that underlies neuropsychological test interpretation.
Closeness of the Solutions of Approximately Decoupled Damped Linear Systems to Their Exact Solutions

The simplest technique of decoupling the normalized equations of motion of a linear nonclassically damped second-order system is to neglect the off-diagonal elements of the normalized damping matrix. In this paper, the error introduced in the system response due to this decoupling technique is studied. Conditions are derived under which the solution of an approximately decoupled system is "close" to the exact solution of the system.
Democracy, Equity and Common Property Resource Management in the Indian Subcontinent

This article addresses the relationship between democracy, equity and common property resource management in South Asia, both at the national and at the local level. Its substantive focus will be largely on forests, and its geographical concentration mostly on India, although other sectors (primarily water) and areas (Nepal and Bangladesh) will also be included. The article opens by looking at Garrett Hardin's (1968) three strategies to preserve the commons. It finds that democratic politics is compatible with both privatization and centralization as conserving strategies (although not necessarily successful). With the third approach—local control—democracy has at best a problematic relationship, for where governmental units are the relevant actors, there tends to be more interest in consuming than in conserving or preserving resources at the local level. Local user groups, however, do much better at common property resource management, because they can restrict membership and thus avoid free riders, and they can establish a close linkage in their members' minds between benefits and costs of participating in group discipline to maintain the resource.
blaCTX-M-27–Encoding Escherichia coli Sequence Type 131 Lineage C1-M27 Clone in Clinical Isolates, Germany

We examined extended-spectrum β-lactamase–producing isolates from livestock, humans, companion animals, food, and the environment during 2009–2016 in Germany for the presence of CTX-M-27 allele within Escherichia coli sequence type (ST) 131. E. coli ST131 C1-M27 was exclusively present in humans; its incidence increased from 0% in 2009 to 45% in 2016.
The not-so-hidden power of mobility and education: Indian diaspora, knowledge industries and the development imperatives

Focusing on the changes in India's higher education sector, this paper looks at the relationship between the growing international mobility, institutions of higher education, skilled workforce production and policy reforms in recent times. Revisiting some of the conceptual issues arising from the literature on transnationalism and Diasporas; and providing a historical context to the shifts in India's education policy, I set up a broader perspective that sees India's investment in its Diasporas as part of the emergence of several new connections. To start, two major changes of recent times need to be understood and analyzed: (a) Initiatives for the vast Indian Diasporas to connect, participate and invest in India and (b) A reorientation of Indian higher education with an emphasis on knowledge-based industries and transnational businesses. These two changes, as the paper argues, complement each other and are closely connected to the global policy regime.
‘As Disposable as the Next Tissue Out of the Box . . .’: Casual Teaching and Job Quality in New South Wales Public School Education

This article builds on recent research into both casualization and job quality or ‘decent work’ by exploring the qualitative aspects of casual employment in the education industry. The article attempts to bridge two distinct positions in the literature on decent work between research that identifies objective components of decent work, and research that focuses on subjective perceptions of job quality. The article focuses on objective aspects of quality work but draws in subjective perceptions both as a path of additional evidence and as a way of capturing the crucial level of personal experience. The article draws on a recent study that explored the experiences of casual school teachers in the New South Wales public education system. It finds that casual employment can erode the job quality of otherwise decent work within professional occupations.