Miracle-dz/UniFAR-FTUs huggingface dataset:
Detection of Clinical Depression in Adolescents’ Speech During Family Interactions

The properties of acoustic speech have previously been investigated as possible cues for depression in adults. However, these studies were restricted to small populations of patients and the speech recordings were made during patients' clinical interviews or fixed-text reading sessions. Symptoms of depression often first appear during adolescence at a time when the voice is changing, in both males and females, suggesting that specific studies of these phenomena in adolescent populations are warranted. This study investigated acoustic correlates of depression in a large sample of 139 adolescents (68 clinically depressed and 71 controls). Speech recordings were made during naturalistic interactions between adolescents and their parents. Prosodic, cepstral, spectral, and glottal features, as well as features derived from the Teager energy operator (TEO), were tested within a binary classification framework. Strong gender differences in classification accuracy were observed. The TEO-based features clearly outperformed all other features and feature combinations, providing classification accuracy ranging between 81%-87% for males and 72%-79% for females. Close, but slightly less accurate, results were obtained by combining glottal features with prosodic and spectral features (67%-69% for males and 70%-75% for females). These findings indicate the importance of nonlinear mechanisms associated with the glottal flow formation as cues for clinical depression.
Hybrid PD-SMC tracking control for serial robot

In this paper, taking the advantages of the simplicity of PD control and the high tracking performance of SMC and avoiding the drawbacks of both control methods, a new hybrid PD-SMC tracking control is proposed for trajectory tracking control of a serial robot by applying the hybridization concept. The unique features of the proposed hybrid control law are the model-free nonlinear feedback control and the globally asymptotic stability. The robustness and effectiveness of the hybrid PD-SMC are investigated through simulations under different operation conditions and for different tasks. It is proved that the hybrid PD-SMC can obtain better tracking performances and is much robust than the standard SMC and PD control.
Freshwater Sponges Have Functional, Sealing Epithelia with High Transepithelial Resistance and Negative Transepithelial Potential

Epithelial tissue — the sealed and polarized layer of cells that regulates transport of ions and solutes between the environment and the internal milieu — is a defining characteristic of the Eumetazoa. Sponges, the most ancient metazoan phylum [1], [2], are generally believed to lack true epithelia [3], [4], [5], but their ability to occlude passage of ions has never been tested. Here we show that freshwater sponges (Demospongiae, Haplosclerida) have functional epithelia with high transepithelial electrical resistance (TER), a transepithelial potential (TEP), and low permeability to small-molecule diffusion. Curiously, the Amphimedon queenslandica sponge genome lacks the classical occluding genes [5] considered necessary to regulate sealing and control of ion transport. The fact that freshwater sponge epithelia can seal suggests that either occluding molecules have been lost in some sponge lineages, or demosponges use novel molecular complexes for epithelial occlusion; if the latter, it raises the possibility that mechanisms for occlusion used by sponges may exist in other metazoa. Importantly, our results imply that functional epithelia evolved either several times, or once, in the ancestor of the Metazoa.
On the Influence of Test-Driven Development on Software Design

Test-driven development (TDD) is an agile software development strategy that addresses both design and testing. This paper describes a controlled experiment that examines the effects of TDD on internal software design quality. The experiment was conducted with undergraduate students in a software engineering course. Students in three groups completed semester-long programming projects using either an iterative test-first (TDD), iterative test-last, or linear test-last approach. Results from this study indicate that TDD can be an effective software design approach improving both code-centric aspects such as object decomposition, test coverage, and external quality, and developer-centric aspects including productivity and confidence. In addition, iterative development approaches that include automated testing demonstrated benefits over a more traditional linear approach with manual tests. This study demonstrates the viability of teaching TDD with minimal effort in the context of a relatively traditional development approach. Potential dangers with TDD are identified regarding programmer motivation and discipline. Pedagogical implications and instructional techniques which may foster TDD adoption will also be referenced
Death of the personality: The grief response of the Alzheimer's disease family caregiver

The grief that follows death is understood and accepted by society. However, the grief associated with certain chronic illness is often misunderstood by family, friends and acquaintances. Unlike a terminal case of cancer where physical deterioration is quite evident, it is difficult to under-stand the grief associated with irreversible dementia because the patient is physically well for most of its duration. What has died in victims of Alzheimer's disease (AD) is the personality that quality or assemblage of qualities that makes a person what he or she is. This paper describes family care-giver responses to providing chronic care for a demented relative and compares and contrasts it with the responses of coping with a non-dementing terminal illness. Based upon our clinical work and empirical research with AD patients and their families, it seems that while many of the AD family caregiver responses are similar to bereavement reactions and anticipatory grieving of other terminal illnesses, the intensity and duration of their responses make them qualitatively different. I nplications for intervention with family caregivers and directions for further research are discussed.
Development and evaluation of an Individualized Outcome Measure (IOM) for randomized controlled trials in mental health

Pre‐defined, researcher‐selected outcomes are routinely used as the clinical end‐point in randomized controlled trials (RCTs); however, individualized approaches may be an effective way to assess outcome in mental health research. The present study describes the development and evaluation of the Individualized Outcome Measure (IOM), which is a patient‐specific outcome measure to be used for RCTs of complex interventions. IOM was developed using a narrative review, expert consultation and piloting with mental health service users (n = 20). The final version of IOM comprises two components: Goal Attainment (GA) and Personalized Primary Outcome (PPO). For GA, patients identify one relevant goal at baseline and rate its attainment at follow‐up. For PPO, patients choose an outcome domain related to their goal from a pre‐defined list at baseline, and complete a standardized questionnaire assessing the chosen outcome domain at baseline and follow‐up. A feasibility study indicated that IOM had adequate completion (89%) and acceptability (96%) rates in a clinical sample (n = 84). IOM was then evaluated in a RCT (ISRCTN02507940). GA and PPO components were associated with each other and with the trial primary outcome. The use of the PPO component of IOM as the primary outcome could be considered in future RCTs. Copyright © 2015 John Wiley & Sons, Ltd.
Intelligent Agents: What We Learned at the Library

We have chosen to begin thinking about intelligent Software agents with a detailed look at what human agents do. Our interest is in agents that provide expert Services to end users. We analyzed data from two studies of reference librarians to see how they provide value to their clients, considering the librarians äs exemplary human agents. Shneiderman (1995) observes that Claims about intelligent Software agents are vague, dreamy and unrealized. We want to bring some precision and optimistic realism to the discussion. Technically, we restrict our consideration of Software agents to small, special-purpose programs that embody a well-bounded description of how to do one thing well, such äs find the latest populär press articles on smoking and hing cancer. Agents can be building blocks; they can use other agents to get their work done. Agents can cooperate, resolve conflicts and share Information, but they are small programs with limited ends. We do not assume a priori that agents should be adaptive or anthropomorphic or consumers of idle cycles or any of the other things sometimes said to characterize intelligent agents. Our exploration of human agents is the entry point for ideas on how to design Software agents. Does it make sense to study humans äs models for Software programs? Often this is not fruitful because the capabilities of people and Computers are so different. But in the case of intelligent agents there is really no other model to follow the very notion of an agent is an intelligent person who helps a client accomplish a goal that either the client cannot accomplish on his own because of ä lack of expertise or a goal that needs to be accomplished with less effort on the client's part. A human agent such äs a secretary or financial planner or reference librarian is engaged to help in just these circumstances. Although we use human agents äs models for intelligent Software agents, we conceive of Software agents äs tools rather than "social actors" (see Nass and Reeves, 1994). The tools perspective matches our vision of agency in that intelligent Software agents are meant to be fully controlled by the user, äs all Software tools are. The notion of a machine äs an actor is picturesque and an ever present theme in science fiction, but such a notion obscures the moral basis of human relationships äs being distinctively grounded in freedom and dignity, qualities neither awarded to nor needed by machines. By acknowledging that machines are not people, we declare that people should be treated differently than machines (see Kaptelinin, 1996; Nardi, 1996; Zinchenko, 1996). Our study of reference librarians was not a conventional user study in which we tried to discover what users were up to so äs to better design for their needs. Rather, we looked at reference librarians primarily äs expert providers of Services, whose work practices could serve äs a model for
A Network Flow Approach to Predict Protein Targets and Flavonoid Backbones to Treat Respiratory Syncytial Virus Infection

Background. Respiratory syncytial virus (RSV) infection is the major cause of respiratory disease in lower respiratory tract in infants and young children. Attempts to develop effective vaccines or pharmacological treatments to inhibit RSV infection without undesired effects on human health have been unsuccessful. However, RSV infection has been reported to be affected by flavonoids. The mechanisms underlying viral inhibition induced by these compounds are largely unknown, making the development of new drugs difficult. Methods. To understand the mechanisms induced by flavonoids to inhibit RSV infection, a systems pharmacology-based study was performed using microarray data from primary culture of human bronchial cells infected by RSV, together with compound-proteomic interaction data available for Homo sapiens. Results. After an initial evaluation of 26 flavonoids, 5 compounds (resveratrol, quercetin, myricetin, apigenin, and tricetin) were identified through topological analysis of a major chemical-protein (CP) and protein-protein interacting (PPI) network. In a nonclustered form, these flavonoids regulate directly the activity of two protein bottlenecks involved in inflammation and apoptosis. Conclusions. Our findings may potentially help uncovering mechanisms of action of early RSV infection and provide chemical backbones and their protein targets in the difficult quest to develop new effective drugs.
Handover strategy of smart mobile terminals among heterogeneous wireless networks

Due to the variety of wireless networks, the handover among heterogeneous wireless networks has become a research hotspot in recent years. More attention have been paid to the radio access network and the core network than the terminal side. In the future the mobile terminal will face a myriad of air interfaces. To roam freely in such a complex network environment, the mobile terminal should be able to handle the known and unknown air interfaces. In this paper, we proposed the smart architecture of the mobile terminal based on multiband multimode radio (MMR), Also we designed a handover strategy for the smart mobile terminal. Using the proposed strategy the mobile terminals can handover among heterogeneous wireless networks and the users can access different network at will with one equipment.
Cell migration and division in amoeboid-like fission yeast

Summary Yeast cells are non-motile and are encased in a cell wall that supports high internal turgor pressure. The cell wall is also essential for cellular morphogenesis and cell division. Here, we report unexpected morphogenetic changes in a Schizosaccharomyces pombe mutant defective in cell wall biogenesis. These cells form dynamic cytoplasmic protrusions caused by internal turgor pressure and also exhibit amoeboid-like cell migration resulting from repeated protrusive cycles. The cytokinetic ring responsible for cell division in wild-type yeast often fails in these cells; however, they were still able to divide using a ring-independent alternative mechanism relying on extrusion of the cell body through a hole in the cell wall. This mechanism of cell division may resemble an ancestral mode of division in the absence of cytokinetic machinery. Our findings highlight how a single gene change can lead to the emergence of different modes of cell growth, migration and division.
Access Point Selection for Hybrid Li-Fi and Wi-Fi Networks

Hybrid light fidelity (Li-Fi) and wireless fidelity (Wi-Fi) networks are an emerging technology for future indoor wireless communications. This hybrid network combines the high-speed data transmission offered by visible light communication and the ubiquitous coverage of radio-frequency techniques. While a hybrid network can improve the system throughput and users’ experience, it also challenges the process of access point selection (APS) due to the mixture of heterogeneous access points. In this paper, the differences between homogeneous and heterogeneous networks regarding APS are discussed, and a two-stage APS method is proposed for hybrid Li-Fi/Wi-Fi networks. In the first stage, a fuzzy logic system is developed to determine the users that should be connected to Wi-Fi. In the second stage, the remaining users are assigned in the environment of a homogeneous Li-Fi network. Compared with the optimisation method, the proposed method achieves a close-to-optimal throughput at significantly reduced complexity. Simulation results also show that our method greatly improves the system throughput over the conventional methods, such as the signal strength strategy and load balancing, at slightly increased complexity.
Le rôle de la confiance organisationnelle dans la réduction des risques sociaux: Le cas des comportements déviants

Parmi les comportements individuels dits extra-role, les comportements deviants, voire dysfonctionnels du point de vue de l’organisation (negligence, agression, vol, etc.), sont generalement assez peu etudies dans la litterature. Ce relatif desinteret peut s’expliquer par un certain nombre de difficultes d’identification et de definition de la notion ; on note egalement une absence de cadre theorique dans lequel il serait possible d’inserer le phenomene. L’article propose une synthese des principales definitions (typologies et categories) des comportements deviants envisages par la litterature. Par ailleurs, sont ici etudies les mecanismes theoriques par lesquels les perceptions par le salarie d’injustice (injustice distributive, injustice procedurale) peuvent influencer les comportements deviants de ce dernier. Ces mecanismes sont analyses en termes de rupture de contrat psychologique et d’ebranlement de la confiance du salarie dans son organisation.
A Characteristic-Point-Based Fuzzy Inference Classifier by a Closeness Matrix

In this paper, a characteristic-point-based fuzzy inference classifier (CPFIC) is proposed to perform two-class classification. Through fuzzy interpolation, a subset of classified samples can be taken as representatives of all samples. They are called characteristic points (CPs). A closeness matrix representing the closeness of two samples in a same class is proposed in selecting CPs. By solving a number of constrained minimizations, the CPFIC is systematically built. Experiments were conducted on four classification problems with known Bayes errors, two benchmark classification problems, and a real-world application used in our research. The CPFIC performs well in accuracy evaluations in all the seven experiments. The summarizing abilities from the CPs into the linguistic descriptions of the fuzzy rule bases were also demonstrated in these examples
Operation modes for cooperating with autonomous functions in intelligent teleoperation systems

Six operation modes for cooperation between manual operation and autonomous functions in intelligent teleoperation systems are proposed. The sequence of mode change is specified so that the operator can change these operation modes intuitively and smoothly. Control schemes of master-slave arms in each mode based on the bilateral control scheme are described. The validity of the proposed operation modes and the mode sequence are confirmed experimentally by using a simple one-degree-of-freedom master-slave manipulator system. It is shown that task efficiency is improved and that the burden on the operator is lightened by introducing the proposed method. <<ETX>>
Regulation of the desensitization and ion selectivity of ATP‐gated P2X2 channels by phosphoinositides

Phosphoinositides (PIPns) are known to regulate the activity of some ion channels. Here we determined that ATP‐gated P2X2 channels also are regulated by PIPns, and investigated the structural background and the unique features of this regulation. We initially used two‐electrode voltage clamp to analyse the electrophysiological properties of P2X2 channels expressed in Xenopus oocytes, and observed that preincubation with wortmannin or LY294002, two PI3K inhibitors, accelerated channel desensitization. K365Q or K369Q mutation of the conserved, positively charged, amino acid residues in the proximal region of the cytoplasmic C‐terminal domain also accelerated desensitization, whereas a K365R or K369R mutation did not. We observed that the permeability of the channel to N‐methyl‐d‐glucamine (NMDG) transiently increased and then decreased after ATP application, and that the speed of the decrease was accelerated by K365Q or K369Q mutation or PI3K inhibition. Using GST‐tagged recombinant proteins spanning the proximal C‐terminal region, we then analysed their binding of the P2X2 cytoplasmic domain to anionic lipids using PIPns‐coated nitrocellulose membranes. We found that the recombinant proteins that included the positively charged region bound to PIPs and PIP2s, and that this binding was eliminated by the K365Q and K369Q mutations. We also used a fluorescence assay to confirm that fusion proteins comprising the proximal C‐terminal region of P2X2 with EGFP expressed in COS‐7 cells closely associated with the membrane. Taken together, these results show that membrane‐bound PIPns play a key role in maintaining channel activity and regulating pore dilation through electrostatic interaction with the proximal region of the P2X2 cytoplasmic C‐terminal domain.
Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer.

PURPOSE To establish the safety, pharmacokinetics, and recommended dose of sunitinib, a novel oral multitargeting tyrosine kinase inhibitor with antiangiogenic and antitumor properties, in patients with advanced malignancies. PATIENTS AND METHODS Sunitinib was given orally for 4 weeks every 6 weeks. RESULTS Twenty-eight patients received doses ranging from 15 to 59 mg/m2 (ranging from 50 mg every other day to 150 mg/d). Dose-limiting toxicities reported at the maximum-tolerated doses > or = 75 mg/d were reversible grade 3 fatigue, grade 3 hypertension, and grade 2 bullous skin toxicity. Therefore, the recommended dose was 50 mg/d. At this dose, the main adverse effects were sore mouth, edema, and thrombocytopenia. Hair discoloration and yellow coloration of the skin were observed at doses > or = 50 mg/d. Pharmacokinetic data indicate that potentially active target plasma concentrations > or = 50 ng/mL can be achieved with moderate interpatient variability and a long half-life compatible with a single daily dosing. Six objective responses were observed in three renal cell carcinomas, one neuroendocrine tumor, one stromal tumor, and one unknown primary adenocarcinoma patient. At higher doses (> or = 75 mg/d), tumor responses were often associated with reduced intratumoral vascularization and central tumor necrosis, eventually resulting in organ perforation or fistula. CONCLUSION At the dose of 50 mg/d (4 weeks on, 2 weeks off), sunitinib displays manageable toxicity. Antitumor activity supports further studies in patients with renal cell carcinoma, gastrointestinal, neuroendocrine, and stromal tumors. Future studies may consider including prospective imaging techniques such as high frequency ultrasound to monitor tumor density.
LiveTrans: Translation Suggestion for Cross-Language Web Search from Web Anchor Texts and Search Results

In this paper we will present a system, called LiveTrans, which can generate translation suggestions for given user queries and provide an English-Chinese cross-language search service for the retrieval of both Web pages and images. The system effectively utilizes two kinds of Web resources: anchor texts and search results. The developed anchor-text-based and search-result-based methods are complementary in the precision and coverage rates and promising in extracting translations of unknown query terms that were not included in general-purpose translation dictionaries. Experimental results demonstrate the feasibility of the system.