Miracle-dz/UniFAR-FTUs huggingface dataset:
Benefits and Limitations of a Community-Engaged Emergency Referral System in a Remote, Impoverished Setting of Northern Ghana

A low-cost emergency and communication transportation system used 3-wheeled motorcycles driven by trained community volunteers. Delivery referrals were redirected from health centers to hospitals capable of advanced services including cesarean deliveries, which was associated with reduced facility-based maternal mortality. A low-cost emergency and communication transportation system used 3-wheeled motorcycles driven by trained community volunteers. Delivery referrals were redirected from health centers to hospitals capable of advanced services including cesarean deliveries, which was associated with reduced facility-based maternal mortality. ABSTRACT Although Ghana has a well-organized primary health care system, it lacks policies and guidelines for developing or providing emergency referral services. In 2012, an emergency referral pilot—the Sustainable Emergency Referral Care (SERC) initiative—was launched by the Ghana Health Service in collaboration with community stakeholders and health workers in one subdistrict of the Upper East Region where approximately 20,000 people reside. The pilot program was scaled up in 2013 to a 3-district (12-subdistrict) plausibility trial that served a population of approximately 184,000 over 2 years from 2013 to 2015. The SERC initiative was fielded as a component of a 6-year health systems strengthening and capacity-building project known as the Ghana Essential Health Intervention Program. Implementation research using mixed methods, including quantitative analysis of key process and health indicators over time in the 12 intervention subdistricts compared with comparison districts, a survey of health workers, and qualitative systems appraisal with community members, provided data on effectiveness of the system as well as operational challenges and potential solutions. Monitoring data show that community exposure to SERC was associated with an increased volume of emergency referrals, diminished reliance on primary care facilities not staffed or equipped to provide surgical care, and increased caseloads at facilities capable of providing appropriate acute care (i.e., district hospitals). Community members strongly endorsed the program and expressed appreciation for the service. Low rates of adherence to some care protocols were noted: referring facilities often failed to alert receiving facilities of incoming patients, not all patients transported were accompanied by a health worker, and receiving facilities commonly failed to provide patient outcome feedback to the referring facility. Yet in areas where SERC worked to bypass substandard points of care, overall facility-based maternal mortality as well as accident-related deaths decreased relative to levels observed in facilities located in comparison areas.
Necessity of admission to improve the hearing-recovery rate in idiopathic sudden sensorineural hearing loss

Abstract Objectives: The purpose of this study was to determine the prognostic potential of admission of a patient for idiopathic sudden sensorineural hearing loss (ISSNHL). Study design: Retrospective clinical study. Methods: We conducted a retrospective study of 301 patients with ISSNHL. The patients were divided into a study (57 patients at out-patients department (OPD) based treatment, using systemic steroids and intra-tympanic (IT) steroid injection) and a control groups (301 patients at admission, using systemic steroids and IT steroid injection). We compared the success rate (15 dB cut off), Siegel’s criteria and hearing gain decibels between two groups. Results: The overall recovery rate of the OPD based treatment group (29.8%) was poor than that of the admission group (52.9%) (p = .002). The odd ratio of OPD based treatment factor was 2.035 when the OPD based treatment and poor prognostic factors were analyzed at logistic regression test (Duration of delayed treatment, 1.073; average hearing loss level, 0.972) (p = .041). Conclusion: Admission must be strongly recommended when the patients with ISSNHL asked about the necessity of admission. We hypothesized that resting, getting out of their social stress, and relief of anxiety might be helpful to their hearing recoveries.
Differential effects of divalent cations on elk prion protein fibril formation and stability

ABSTRACT Misfolding of the normally folded prion protein of mammals (PrPC) into infectious fibrils causes a variety of diseases, from scrapie in sheep to chronic wasting disease (CWD) in cervids. The misfolded form of PrPC, termed PrPSc, or in this case PrPCWD, interacts with PrPC to create more PrPCWD. This process is not clearly defined but is affected by the presence and interactions of biotic and abiotic cofactors. These include nucleic acids, lipids, glycosylation, pH, and ionic character. PrPC has been shown to act as a copper-binding protein in vivo, though it also binds to other divalents as well. The significance of this action has not been conclusively elucidated. Previous reports have shown that metal binding sites occur throughout the N-terminal region of PrPC. Other cations like manganese have also been shown to affect PrPC abundance in a transcript-independent fashion. Here, we examined the ability of different divalent cations to influence the stability and in vitro conversion of two variants of PrP from elk (L/M132, 26–234). We find that copper and zinc de-stabilize PrP. We also find that PrP M132 exhibits a greater degree of divalent cation induced destabilization than L132. This supports findings that leucine at position 132 confers resistance to CWD, while M132 is susceptible. However, in vitro conversion of PrP is equally suppressed by either copper or zinc, in both L132 and M132 backgrounds. This report demonstrates the complex importance of ionic character on the PrPC folding pathway selection on the route to PrPSc formation.
Remote sensing observation of annual dust cycles and possible causality of Kawasaki disease outbreaks in Japan

Kawasaki disease (KD) is a rare vascular disease that, if left untreated, can result in irreparable cardiac damage in children. While the symptoms of KD are well-known, as are best practices for treatment, the etiology of the disease and the factors contributing to KD outbreaks remain puzzling to both medical practitioners and scientists alike. Recently, a fungus known as Candida, originating in the farmlands of China, has been blamed for outbreaks in China and Japan, with the hypothesis that it can be transported over long ranges via different wind mechanisms. This paper provides evidence to understand the transport mechanisms of dust at different geographic locations and the cause of the annual spike of KD in Japan. Candida is carried along with many other dusts, particles or aerosols, of various sizes in major seasonal wind currents. The evidence is based upon particle categorization using the Moderate Resolution Imaging Spectrometer (MODIS) Aerosol Optical Depth (AOD), Fine Mode Fraction (FMF) and Ångström Exponent (AE), the Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) attenuated backscatter and aerosol subtype, and the Aerosol Robotic Network’s (AERONET) derived volume concentration. We found that seasonality associated with aerosol size distribution at different geographic locations plays a role in identifying dominant abundance at each location. Knowing the typical size of the Candida fungus, and analyzing aerosol characteristics using AERONET data reveals possible particle transport association with KD events at different locations. Thus, understanding transport mechanisms and accurate identification of aerosol sources is important in order to understand possible triggers to outbreaks of KD. This work provides future opportunities to leverage machine learning, including state-of-the-art deep architectures, to build predictive models of KD outbreaks, with the ultimate goal of early forecasting and intervention within a nascent global health early-warning system.
Bran Bread: Chemical Composition, Fungal Load, Biological Impacts and Intervention

Bran breads were purchased and collected from different markets and bakeries of different suburbs fourteen Egyptian governorates. Chemical compositions as moisture content, crude protein, fiber, fat, ash, minerals "Fe, Zn and Cu" were estimated to the collected bran breads and carbohydrate content was calculated by difference, furthermore; phytates as antinutritional content and total aflatoxin and ochratoxin were estimated. According to the iron and zinc contents the collected bran breads were reduce to two subjected samples of high level (84.0 ppm Fe + 33.5 ppm Zn) and low level (48.5 ppm Fe + 26.0 ppm Zn) respectively. Fortified bran breads with EDTA and Ascorbate salts of the same two Fe and Zn levels were baked and 24- participants shared in pannel test of the sensory evaluation and identification trials of the fortified 4- wheat flour samples showed that; the isolated fungi belong to 5 genera and 14.0 species about 303 isolates from all samples, it should be free raw material used from fungi and specially mycotoxins fungi such as A. flavus to reduce the risks for consumers' health to used bran flour. Experiments were initially designed to evaluate the biological impacts for collected and baked bran breads in their two different iron and zinc concentrations in vivo as designed and to evaluate the copper levels in terms of cholesterol levels. The duration of these experiments was 90- days divided into 2- intervals "Depletion & Repletion"; 45- days for each. All bran bread, whether collected from the Egyptian markets or baked not acted upon the body weight of the subjected rats as compared with controller during the depletion period (p ˃0.05). The collected bran breads contributed to Fe, Zn and Cu deficiencies, decline in hemoglobin, RBC's, WBC's, HDL- C and caused histopathological changes on hearts and livers of rats. The baked bran breads whether fortified with two EDTA salts or two ascorbate salts were intervention for amelioration for CBC of the unsound rats.
Improving Interpretation of Cardiac Phenotypes and Enhancing Discovery With Expanded Knowledge in the Gene Ontology

Background: A systems biology approach to cardiac physiology requires a comprehensive representation of how coordinated processes operate in the heart, as well as the ability to interpret relevant transcriptomic and proteomic experiments. The Gene Ontology (GO) Consortium provides structured, controlled vocabularies of biological terms that can be used to summarize and analyze functional knowledge for gene products. Methods and Results: In this study, we created a computational resource to facilitate genetic studies of cardiac physiology by integrating literature curation with attention to an improved and expanded ontological representation of heart processes in the Gene Ontology. As a result, the Gene Ontology now contains terms that comprehensively describe the roles of proteins in cardiac muscle cell action potential, electrical coupling, and the transmission of the electrical impulse from the sinoatrial node to the ventricles. Evaluating the effectiveness of this approach to inform data analysis demonstrated that Gene Ontology annotations, analyzed within an expanded ontological context of heart processes, can help to identify candidate genes associated with arrhythmic disease risk loci. Conclusions: We determined that a combination of curation and ontology development for heart-specific genes and processes supports the identification and downstream analysis of genes responsible for the spread of the cardiac action potential through the heart. Annotating these genes and processes in a structured format facilitates data analysis and supports effective retrieval of gene-centric information about cardiac defects.
Selection of working correlation structure in generalized estimating equations

The well‐known generalized estimating equations is a very popular approach for analyzing longitudinal data. Selecting an appropriate correlation structure in the generalized estimating equations framework is a key step for estimating parameters efficiently and deriving reliable statistical inferences. We present two new criteria for selecting the best among the candidates with any arbitrary structures, even for irregularly timed measurements. The simulation results demonstrate that the new criteria perform more similarly to EAIC and EBIC as the sample size becomes large. However, their performance is much enhanced when the sample size is small and the number of measurements is large. Finally, three real datasets are used to illustrate the proposed criteria. Copyright © 2017 John Wiley & Sons, Ltd.
Automated Curriculum Learning by Rewarding Temporally Rare Events

Reward shaping allows reinforcement learning (RL) agents to accelerate learning by receiving additional reward signals. However, these signals can be difficult to design manually, especially for complex RL tasks. We propose a simple and general approach that determines the reward of pre-defined events by their rarity alone. Here events become less rewarding as they are experienced more often, which encourages the agent to continually explore new types of events as it learns. The adaptiveness of this reward function results in a form of automated curriculum learning that does not have to be specified by the experimenter. We demonstrate that this Rarity of Events (RoE) approach enables the agent to succeed in challenging VizDoom scenarios without access to the extrinsic reward from the environment. Furthermore, the results demonstrate that RoE learns a more versatile policy that adapts well to critical changes in the environment. Rewarding events based on their rarity could help in many unsolved RL environments that are characterized by sparse extrinsic rewards but a plethora of known event types.
PREPARATION AND PROPERTIES OF CARBON NANOTUBES/NATURAL RUBBER COMPOSITES

The preparation technology and performances of carbon nanotubes/natural rubber composites were studied.After the carbon nanotubes were added into natural rubber matrix,the area of crystal-melting peak of DSC curve of rubber decreases.At the same time,the scorch time of rubber shortens slightly,and the curing reversion reduces.The dispersing of carbon nanotubes in rubber and the adhesion between carbon nanotubes and rubber are improved after being treated with the dispersing-bonding system.The mechanical properties of carbon nanotubes composites increase.The rebound degree and the dynamic compress properties of carbon nanotubes composites are more superior to those of natural rubber filled with carbon black.Compared with the sample filled with carbon black,the storage modulus and the glass transition temperature of carbon nanotubes reinforced composites are higher,and the thermal stability is also preferable.
Effect of chondroitin sulfate proteoglycans on neuronal cell adhesion, spreading and neurite growth in culture

As one major component of extracellular matrix (ECM) in the central nervous system, chondroitin sulfate proteoglycans (CSPGs) have long been known as inhibitors enriched in the glial scar that prevent axon regeneration after injury. Although many studies have shown that CSPGs inhibited neurite outgrowth in vitro using different types of neurons, the mechanism by which CSPGs inhibit axonal growth remains poorly understood. Using cerebellar granule neuron (CGN) culture, in this study, we evaluated the effects of different concentrations of both immobilized and soluble CSPGs on neuronal growth, including cell adhesion, spreading and neurite growth. Neurite length decreased while CSPGs concentration arised, meanwhile, a decrease in cell density accompanied by an increase in cell aggregates formation was observed. Soluble CSPGs also showed an inhibition on neurite outgrowth, but it required a higher concentration to induce cell aggregates formation than coated CSPGs. We also found that growth cone size was significantly reduced on CSPGs and neuronal cell spreading was restrained by CSPGs, attributing to an inhibition on lamellipodial extension. The effect of CSPGs on neuron adhesion was further evidenced by interference reflection microscopy (IRM) which directly demonstrated that both CGNs and cerebral cortical neurons were more loosely adherent to a CSPG substrate. These data demonstrate that CSPGs have an effect on cell adhesion and spreading in addition to neurite outgrowth.
Clinical characteristics of COPD patients with tidal expiratory flow limitation

We have used impulse oscillometry to identify COPD patients with tidal expiratory flow limitation (EFL), which is a measurement related to small airway disease. We report that 37.4% of COPD patients had EFL; these patients had multiple clinical characteristics of more severe disease including lower forced expiratory volume in 1 second values, greater hyperinflation, reduced exercise performance, and increased small airway impairment. We highlight that EFL can be used to identify a subgroup of COPD patients with distinct characteristics associated with small airway disease.
Efficacy and tolerability of a complex homeopathic drug in children suffering from dry cough-A double-blind, placebo-controlled, clinical trial

Abstract Background A randomised, placebo-controlled clinical trial in children suffering from acute dry cough was performed to assess the efficacy and tolerability of a complex homeopathic drug (Drosera, Coccus cacti, Cuprum Sulfuricum, Ipecacuanha=Monapax syrup, short: verum). Methods 89 children received verum and 91 received placebo daily for 7 days (age groups 0.5–3, 4–7 and 8–12 years). The primary efficacy variable was the improvement of the Cough Assessment Score. Tolerability and compliance were also assessed. A confirmatory statistical analysis was performed for the primary efficacy variable and a descriptive analysis for the secondary parameters. Results The Cough Assessment Score showed an improvement of 5.2±2.6 points for children treated with verum and 3.2±2.6 points in the placebo group (p<0.0001). The difference of the least square means of the improvements was 1.9±0.4. The effect size of Cohen´s d was d=0.77. In all secondary parameters the patients in the verum group showed higher rates of improvement and remission than those in the placebo group. In 15 patients (verum: n=6; placebo: n=9) 18 adverse drug reactions of mild or moderate intensity were observed. Conclusions Administering verum resulted in a statistically significantly greater improvement of the Cough Assessment Score than the placebo. The tolerability was good and not inferior to that of the placebo.
Glypican-6 promotes the growth of developing long bones by stimulating Hedgehog signaling

Autosomal-recessive omodysplasia (OMOD1) is a genetic condition characterized by short stature, shortened limbs, and facial dysmorphism. OMOD1 is caused by loss-of-function mutations of glypican 6 (GPC6). In this study, we show that GPC6-null embryos display most of the abnormalities found in OMOD1 patients and that Hedgehog (Hh) signaling is significantly reduced in the long bones of these embryos. The Hh-stimulatory activity of GPC6 was also observed in cultured cells, where this GPC increased the binding of Hh to Patched 1 (Ptc1). Consistent with this, GPC6 interacts with Hh through its core protein and with Ptc1 through its glycosaminoglycan chains. Hh signaling is triggered at the primary cilium. In the absence of Hh, we observed that GPC6 is localized outside of the cilium but moves into the cilium upon the addition of Hh. We conclude that GPC6 stimulates Hh signaling by binding to Hh and Ptc1 at the cilium and increasing the interaction of the receptor and ligand.
Spectrum graph coloring and applications to WiFi channel assignment

We introduce and explore a family of vertex-coloring problems, which, surprisingly enough, have not been considered before despite stemming from the problem of Wi-Fi channel assignment. Given a spectrum of colors, endowed with a matrix of interferences between each pair of colors, the Threshold Spectrum Coloring problem fixes the number of colors available and aims to minimize the interference threshold, i.e., the maximum of the interferences at the vertices. Conversely, the Chromatic Spectrum Coloring problem fixes a threshold and aims to minimize the number of colors for which respecting that threshold is possible. As the main theoretical results, we prove tight upper bounds for the solutions to each problem. Since both problems turn out to be NP-hard, we complete the scene with experimental results. We propose a DSATUR-based heuristic and study its performance to minimize the maximum vertex interference in Wi-Fi channel assignment, both for randomly-generated graphs and for a real-world scenario. Further, for all these graphs, we experimentally check the goodness of the theoretical bounds.
Absorption non-uniformity characterisation and its impact on flexographic ink distribution of coated packaging boards

Absorption and surface roughness of a substrate are believed to impact flexographic print mottle. However, their respective contributions are not that well recognized as they always co-exist. In addition to average absorption rate, absorption uniformity is of higher importance and even more difficult to separate from surface roughness. Therefore we propose a method to independently study the effects of absorption non-uniformity on print quality. This is achieved by introducing artificial absorption non-uniformity with well-controlled barrier patterns. The barrier patterns are added onto coated boards by means of flexographic printing with appropriate chemicals. These patterns modify not only surface chemistry but also pore structure by closing the surface pores.This article provides proof of the concept, which has successfully been applied to seven coated liquid boards. For the first time, this technique enables one to create a property-matrix, absorption non-uniformity vs. e.g. surface roughness. From this matrix the impact from either of the properties on print mottle can be studied independently. Experimental investigations showed that the level of absorption non-uniformity in a coated board had clear impact on print mottle. In most cases the relationship appeared to be linear, though the degree of impact differed from one board to another. This suggests that the print was more sensitive to uneven absorbency on some samples. This may be contributed to relative importance of other properties including the original non-uniformity of the board surface. When absorption non-uniformity is at a constant and low level, the effects of surface roughness becomes more pronounced.
Levels of Lycopene β-Cyclase 1 Modulate Carotenoid Gene Expression and Accumulation in Daucus carota

Plant carotenoids are synthesized and accumulated in plastids through a highly regulated pathway. Lycopene β-cyclase (LCYB) is a key enzyme involved directly in the synthesis of α-carotene and β-carotene through the cyclization of lycopene. Carotenoids are produced in both carrot (Daucus carota) leaves and reserve roots, and high amounts of α-carotene and β-carotene accumulate in the latter. In some plant models, the presence of different isoforms of carotenogenic genes is associated with an organ-specific function. D. carota harbors two Lcyb genes, of which DcLcyb1 is expressed in leaves and storage roots during carrot development, correlating with an increase in carotenoid levels. In this work, we show that DcLCYB1 is localized in the plastid and that it is a functional enzyme, as demonstrated by heterologous complementation in Escherichia coli and over expression and post transcriptional gene silencing in carrot. Transgenic plants with higher or reduced levels of DcLcyb1 had incremented or reduced levels of chlorophyll, total carotenoids and β-carotene in leaves and in the storage roots, respectively. In addition, changes in the expression of DcLcyb1 are accompanied by a modulation in the expression of key endogenous carotenogenic genes. Our results indicate that DcLcyb1 does not possess an organ specific function and modulate carotenoid gene expression and accumulation in carrot leaves and storage roots.