Miracle-dz/UniFAR-FTUs huggingface dataset:
Does resilience mediate the effects of bullying in nurses

The overarching purpose of the research was to examine workplace bullying among nurses who work in North Carolina hospital. The research examines the influence of individual factors, individual characteristics and organization factors on physical health, mental health and intent to leave position in nurses who were bullied. In particular, this study explored the influence of resilience on physical health, mental health and intent to leave in nurses who have experienced bullying. In this sample, 64 of 160 (40%) of nurses experienced workplace bullying. Linear regression analysis indicated nurses who are bullied have a lower average scores in mental health measures (p<0.001), and are more likely to leave their unit (p<0.001). Multiple regression models revealed that nurses who experienced severe bullying and had high levels of resilience their intention to leave their unit was elevated as compared to others. The mediation results from the path analysis using Mplus reveled resilience was not a mediator of bullying on physical health, mental health or intent to leave.
Efficient Driver Fatigue Detection and Alerting System Miss

In order to the drowsy driver, this paper contains a new fatigue driving detection algorithm. Experts told that such drivers who do not take usual break, when driving long distance can be feeling sleepy. Most of the severe road accidents are caused by sleepy drivers than drink driving. In order to avoid accidents fatigue detection method will detect early signs of fatigue in drivers. If driver is falling symptoms of weariness then immediately message is generated that driver is fatigue, then this message will be transferred to the control room in COMMAND navigation system that indicating status of driver. The fatigue is detected in the system by image processing method of comparing the images in video and by using human features we will detect the driver is fatigue or not.
Hybrid modulator for power converters in parallel topology

This paper presents a new mixed modulator that combines interleaving and spread-spectrum techniques in order to achieve the lowest level of conducted EMI generation. This modulator is addressed to power converters in parallel arrangement. The practical details of the hybrid modulator and controller implementation on a FPGA are explained. The characteristics of such modulator in terms of EMI reduction and converter performance are theoretically explored and experimentally validated in a four channel parallel buck converter operating in closed loop.
Comparing Alternative Algebraic Modalities for Remedial Students.

This paper reports that the student population enrolled in remedial mathematics is rapidly increasing, while funding for these classes in Florida is declining. The Math Department at the Winter Park Campus (WPC) of Florida's Valencia Community College (VCC) has developed a curriculum that offers a variety of instructional formats to its remedial students. Since 1995, VCC has been transforming itself from a teaching-centered institution to a learning-centered one. The Math Department tested three learning modalities: traditional lecture, Academic Systems (an Internet-accessed software curriculum that provides students with combinations of lectures, practice programs, and self-administered assessment tests), and ALEKS (a non-linear, non-traditional Internet-based course) . The traditional lecture class had the highest retention rate (60%), ALEKS the lowest (39%). However, there was not a significant difference in outcomes when students were placed in a learning modality that reflected their preferred learning style. According to a student survey, although 83% of remedial algebra students preferred lecture format, the authors argue that the 17% who preferred non-traditional methods need access to nontraditional learning methods. This report also provides demographic statistics regarding WPC's students: (1) with 1,500 credit students, WPC is the smallest of the four campuses in the VCC system; (2) WPC's student body is 69% Caucasian, 14% African American, and 12% Hispanic; (3) 65% of enrolled students are female, and over 75% of students are enrolled part time; and (4) the average student is 27 years old. Appended are course management suggestions and student survey results. (NB) Reproductions supplied by EDRS are the best that can be made from the original document. 0 0 Comparing Alternative Algebraic Modalities For Remedial Students Marie McClendon Michele McArdle A Paper Presented at the Chair Academy Leadership Conference Kansas City, Missouri February, 2002 PERMISSION TO REPRODUCE AND DISSEMINATE THIS MATERIAL HAS BEEN GRANTED BY TO THE EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC) 1 U.S. DEPARTMENT OF EDUCATION Office of Educational Resew ch and Improvement EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC) This document has been reproduced as received from the person or organization originating it. 0 Minor changes have heen made to improve reproduction quality. Points of view or opinions stated in this document do not necessarily represent official OERI positior. or policy. Comparing Alternative Algebraic Modalities For Remedial Students
Microenvironmental Control of the Breast Cancer Cell Cycle

The mammary gland is one of the best‐studied examples of an organ whose structure and function are influenced by reciprocal signaling and communication between cells and their microenvironment. The mammary epithelial cell (MEC) microenvironment includes stromal cells and extracellular matrix (ECM). Abundant evidence shows that the ECM and growth factors co‐operate to regulate cell cycle progression, and that the ECM is altered in breast tumors. In particular, mammographically dense breast tissue is a significant risk factor for developing breast carcinomas. Dense breast tissue is associated with increased stromal collagen and epithelial cell content. In this article, we overview recent studies addressing the effects of ECM composition on the breast cancer cell cycle. Although the normal breast ECM keeps the MEC cycle in check, the ECM remodeling associated with breast cancer positively regulates the MEC cycle. ECM effects on the downstream biochemical and mechanosignaling pathways in both normal and tumorigenic MECs will be reviewed. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.
Effect of a Self-Efficacy Computational Activator on the Learning Achievement in Students of Different Cognitive Style

The present research contrasts the effect of the presence or absence of a module of self-efficacy in a hypermedia, on the achievement of learning as a solution to problems with fractional numbers. The interaction between the variable of learning achievement, and the cognitive styles of students in the dimension of the dependence – independence field was examined. Fifty (50) students participated in two courses which previously constituted fifth grade primary school education at a public institution in Soacha (Cun-dinamarca - Colombia). With regards to data processing, an Ancova analysis was done, which showed significant and positive effects on the learning achievement through the presence of the self-efficacy module. Moreover, it was evinced that the differences of achievement among the students of distinct cognitive styles disappeared.
Onto Confounding-Aware Subgroup Discovery

This paper presents a semi-automatic approach for confounding-aware subgroup discovery: We present a method that provides the means for detecting potentially confounded subgroup patterns, other unconfounded relations, and/or patterns that are affected by effect- modification. Since there is no purely automatic test for confounding, the discovered relations are subsequently presented to the user in a semi-automatic approach. Furthermore, we show how to utilize (causal) domain knowledge for improving the results of the algorithm, since confounding is itself a causal concept. The applicability and benefit of the presented technique is illustrated by examples from a case-study in the medical domain.
Response to Peter Thompson Interview from Michael Adams

In the following comments, I have chosen three broad themes raised by the paper, “From Movement to Management: Aboriginal assertion, government and environmentalist responses and some ways forward regarding conservation and social justice” and engaged with them in terms of the paper itself, their relationship to my own work, and how they illuminate the symposium questions, including comparisons with India.
Calcium-dependent inactivation of light-sensitive channels in Drosophila photoreceptors

Whole-cell voltage clamp recordings were made from photoreceptors of dissociated Drosophila ommatidia under conditions when the light- sensitive channels activate spontaneously, generating a "rundown current" (RDC). The Ca2+ and voltage dependence of the RDC was investigated by applying voltage steps (+80 to -100 mV) at a variety of extracellular Ca2+ concentrations (0-10 mM). In Ca(2+)-free Ringer large currents are maintained tonically throughout 50-ms-long voltage steps. In the presence of external Ca2+, hyperpolarizing steps elicit transient currents which inactivate increasingly rapidly as Ca2+ is raised. On depolarization inactivation is removed with a time constant of approximately 10 ms at +80 mV. The Ca(2+)-dependent inactivation is suppressed by 10 mM internal BAPTA, suggesting it requires Ca2+ influx. The inactivation is absent in the trp mutant, which lacks one class of Ca(2+)-selective, light-sensitive channel, but appears unaffected by the inaC mutant which lacks an eye-specific protein kinase C. Hyperpolarizing voltage steps applied during light responses in wild- type (WT) flies before rundown induce a rapid transient facilitation followed by slower inhibition. Both processes accelerate as Ca2+ is raised, but the time constant of inhibition (12 ms with 1.5 mM external Ca2+ at -60 mV) is approximately 10 times slower than that of the RDC inactivation. The Ca(2+)-mediated inhibition of the light response recovers in approximately 50-100 ms on depolarization, recovery being accelerated with higher external Ca2+. The Ca2+ and voltage dependence of the light-induced current is virtually eliminated in the trp mutant. In inaC, hyperpolarizing voltage steps induced transient currents which appeared similar to those in WT during early phases of the light response. However, 200 ms after the onset of light, the currents induced by voltage steps inactivated more rapidly with time constants similar to those of the RDC. It is suggested that the Ca(2+)-dependent inactivation of the light-sensitive channels first occurs at some concentration of Ca2+ not normally reached during the moderate illumination regimes used, but that the defect in inaC allows this level to be reached.
Chapter 19 Information Spreading in Dynamic Networks : An Analytical Approach

Sensor networks is one of the most relevant concrete examples of dynamic networks. Their dynamic behaviour is mainly due to the presence of node/link faults and node mobility. The aim of this chapter is to survey a new approach to study such dynamic networks, recently introduced in [15–19]. The major novelty of this approach relies on two basic issues. 1. The dynamic network is modeled as an evolving graph whose topology changes at every time according to some law/adversary. Both worst-case adversarial scenarios and graphs that evolve randomly are deeply studied. 2. This new approach provides a general framework where it is possible to determine the speed of information spreading from an analytical point view. Does the dynamic unknown behaviour of sensor networks always slow-down the speed of information spreading? Which is the real impact of this dynamic behaviour on the completion time of some basic communication protocols? Can unknown random node-mobility be exploited to asymptotically speed-up information spreading? This new general approach provides some clean mathematical answers to the above fundamental questions.
Tubal sterilization.

Although tubal sterilization is considered a permanent method of fertility control, pregnancy can occur after a successful procedure. In the first year after tubal sterilization, the estimated failure rate is 0.1-0.8%. Approximately one-third of these pregnancies are ectopic. Women under 35 years of age and those who are not lactating after sterilization are more likely to conceive. Incomplete coagulation or misplacement of the mechanical device also raises the risk of failure. In a study reported in this issue of "The New England Journal of Medicine," the 10-year cumulative rate of ectopic pregnancy after tubal sterilization was 7.3/1000 procedures. The frequency of ectopic pregnancy was highest after bipolar coagulation and lowest after postpartum partial salpingectomy. Tubal sterilization should be carried out with clips or rings rather than by coagulation, both because of the lower risk of ectopic pregnancy and the greater likelihood of successful pregnancy if reversal is sought.
Phosphoethanolamine Decoration of Neisseria gonorrhoeae Lipid A Plays a Dual Immunostimulatory and Protective Role during Experimental Genital Tract Infection

ABSTRACT The induction of an intense inflammatory response by Neisseria gonorrhoeae and the persistence of this pathogen in the presence of innate effectors is a fascinating aspect of gonorrhea. Phosphoethanolamine (PEA) decoration of lipid A increases gonococcal resistance to complement-mediated bacteriolysis and cationic antimicrobial peptides (CAMPs), and recently we reported that wild-type N. gonorrhoeae strain FA1090 has a survival advantage relative to a PEA transferase A (lptA) mutant in the human urethral-challenge and murine lower genital tract infection models. Here we tested the immunostimulatory role of this lipid A modification. Purified lipooligosaccharide (LOS) containing lipid A devoid of the PEA modification and an lptA mutant of strain FA19 induced significantly lower levels of NF-κB in human embryonic kidney Toll-like receptor 4 (TLR4) cells and murine embryonic fibroblasts than wild-type LOS of the parent strain. Moreover, vaginal proinflammatory cytokines and chemokines were not elevated in female mice infected with the isogenic lptA mutant, in contrast to mice infected with the wild-type and complemented lptA mutant bacteria. We also demonstrated that lptA mutant bacteria were more susceptible to human and murine cathelicidins due to increased binding by these peptides and that the differential induction of NF-κB by wild-type and unmodified lipid A was more pronounced in the presence of CAMPs. This work demonstrates that PEA decoration of lipid A plays both protective and immunostimulatory roles and that host-derived CAMPs may further reduce the capacity of PEA-deficient lipid A to interact with TLR4 during infection.
Hair cells: transduction, tuning, and transmission in the inner ear.

STRUCTURE AND STIMULATION OF HAIR CELLS . 64 Stimulation of Hair Bundles . 64 Structure of Hair Bundles . 67 Development and Repair of Hair Bundles . 70
Personalized E-News Monitoring Agent System for Tracking the User-Interested Chinese News Events

The study presents a personalized e-news monitoring agent system which employs the topic tracking based approach for tracking the user-interested news events. The proposed scheme simultaneously considers both the similarities and the semantic relationships among news topics to track the user-interested news topics. Additionally, the Chinese word segmentation system ECScanner with new words' extension mechanism is proposed to perform Chinese word segmentation process herein. The experimental results indicated that using the proposed ECScanner with new words' extension mechanism to perform Chinese word segmentation process can obviously promote the accuracy rate of tracking the user-interested news events.
Highlights on distinctive structural and functional properties of HTLV Tax proteins

Human T cell leukemia viruses (HTLVs) are complex human retroviruses of the Deltaretrovirus genus. Four types have been identified thus far, with HTLV-1 and HTLV-2 much more prevalent than HTLV-3 or HTLV-4. HTLV-1 and HTLV-2 possess strictly related genomic structures, but differ significantly in pathogenicity, as HTLV-1 is the causative agent of adult T cell leukemia and of HTLV-associated myelopathy/tropical spastic paraparesis, whereas HTLV-2 is not associated with neoplasia. HTLVs code for a protein named Tax that is responsible for enhancing viral expression and drives cell transformation. Much effort has been invested to dissect the impact of Tax on signal transduction pathways and to identify functional differences between the HTLV Tax proteins that may explain the distinct oncogenic potential of HTLV-1 and HTLV-2. This review summarizes our current knowledge of Tax-1 and Tax-2 with emphasis on their structure, role in activation of the NF-κB (nuclear factor kappa-B) pathway, and interactions with host factors.
O R I G I N a L I N V E S T I G a T I O N Open Access

Adiponectin, resistin and IL-6 plasma levels in subjects with diabetic foot and possible correlations with clinical variables and cardiovascular co-morbidity Abstract Introduction: It is very suggestive that diabetic foot is characterized by a pronounced inflammatory reaction and the pathogenic significance of this inflammation has received little attention. On this basis the aim of our study was to evaluate plasma levels of adiponectin, resistin and IL-6 in subjects with diabetic foot in comparison with subjects without foot complications. Materials and methods: We recruited 34 subjects with type 2 diabetes mellitus and foot ulceration hospitalized for every condition related to diabetic disease, but not for new vascular events (group A). As controls we recruited 37 patients with type 2 diabetes mellitus without foot ulceration (group B) hospitalized for every condition related to diabetic disease, but not for new vascular events. Adiponectin, Resistin and IL-6 serum levels were evaluated.
Investigating the prognostic value of KOC (K homology domain containing protein overexpressed in cancer) overexpression after curative intent resection of pancreatic ductal adenocarcinoma.

BACKGROUND Pancreatic adenocarcinoma (PDAC) is now the third leading cause of cancer mortality in the United States. More than 80% of patients present with distant metastasis precluding surgical eligibility. Even among patients with localized disease deemed eligible for surgical resection, the median survival is only 22.8 months due to high recurrence rates. Identification of a biomarker correlated with patient specific prognosis upon initial diagnosis can serve as a way to individualize treatment options. METHODS We performed a retrospective cohort study analyzing pathology of patients who underwent curative intent surgery for PDAC at Geisinger Medical Center from 1998-2011 to identify whether the expression of KOC can be predictive of patient specific prognosis. Tissue microarrays of specimens were assessed by immunohistochemistry. RESULTS A total of 62 patients are included. Comparisons between groups on overall survival (OS) and progression free survival (PFS) are estimated using the Kaplan-Meier method and the log-rank test. Each biomarker was represented as low and high expression by categorizing the expression score at <4+ or >4+, based on intensity and extent of cells stained. 40 deaths occurred in the sample. Distant metastasis and differentiation (well/moderate vs. poor) were related to OS (P=0.0120, P=0.0086). Twenty-nine patients progressed in their disease. High/low KOC expression were significantly related to PFS (P=0.0556). Patients with a high KOC expression were more than 2 times more likely to progress compared to those with a low KOC expression (HR =2.04; 95% CI: 0.97, 4.29). CONCLUSIONS Our data is suggestive of KOC being a useful prognostic biomarker for identifying those patients with PDAC who have a high risk for early progression and distant metastasis. Larger studies are needed to determine whether KOC can be a therapeutic target in the treatment of pancreatic cancer. Furthermore, considering high KOC expressers had a worse PFS than their counterparts, investigation regarding the use of KOC expression as a biomarker to preselect patients who may benefit most from neoadjuvant chemotherapy is warranted.
A Net Practice for Software Project Management

Technical and managerial complexity increasingly overwhelm project managers. To rein in that complexity, the authors propose PM-Net, a model that captures the concurrent, iterative, and evolutionary nature of software development. It adopts the basic concepts of Petri nets, graphical models of information flow, with extensions to represent both decisions and artifacts.
Evo-devo, deep homology and FoxP2: implications for the evolution of speech and language

The evolution of novel morphological features, such as feathers, involves the modification of developmental processes regulated by gene networks. The fact that genetic novelty operates within developmental constraints is the central tenet of the ‘evo-devo’ conceptual framework. It is supported by findings that certain molecular regulatory pathways act in a similar manner in the development of morphological adaptations, which are not directly related by common ancestry but evolved convergently. The Pax6 gene, important for vision in molluscs, insects and vertebrates, and Hox genes, important for tetrapod limbs and fish fins, exemplify this ‘deep homology’. Recently, ‘evo-devo’ has expanded to the molecular analysis of behavioural traits, including social behaviour, learning and memory. Here, we apply this approach to the evolution of human language. Human speech is a form of auditory-guided, learned vocal motor behaviour that also evolved in certain species of birds, bats and ocean mammals. Genes relevant for language, including the transcription factor FOXP2, have been identified. We review evidence that FoxP2 and its regulatory gene network shapes neural plasticity in cortico-basal ganglia circuits underlying the sensory-guided motor learning in animal models. The emerging picture can help us understand how complex cognitive traits can ‘descend with modification’.
Kernel Partial Least-Squares Regression

A couple of regularized least squares regression models in a feature space are extended by the kernel partial least squares (KPLS) regression model in this paper. PLS is a method based on the projection of input (explanatory) variables to the latent variables (components), and has been developed and established as one of the multivariate statistical process control (MSPC) methods. With PLS, the regression matrix is determined on the basis of a subset of the predictor variables and thus, PLS is able to reduce the number of variables to be considered. In this paper, two kinds of KPLS algorithm for construction of nonlinear regression models in possibly high-dimensional feature spaces are provided. According to the idea of structural risk minimization (SRM), the work described here provides an index of generalization errors. We give the theoretical description of the KPLS algorithms and experimentally compare the algorithms with some existing PLS and KPLS regression models. We will demonstrate that on the data sets employed KPLS achieves better results than PLS and some other KPLS. At the same time, validity of index of generalization errors is proved affirmatively.