Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence of Alcohol Consumption and Hazardous Drinking, Tobacco and Drug Use in Urban Tanzania, and Their Associated Risk Factors

Evidence suggests substance abuse in Tanzania is a growing public health problem. A random sample of 899 adults aged 15–59 in two urban sites of differing levels of poverty surveyed alcohol, tobacco and illicit substance use. Rates of substance use were 17.2%. 8.7% and 0.8% for alcohol, tobacco and cannabis, respectively. Living in the less affluent area was associated with higher lifetime rates of tobacco and alcohol use. Substance use is less prevalent in Tanzania than in richer countries, but lifetime consumption is higher in poorer areas. The association of substance use with a range of socio-economic factors warrants further research.
A sparse model predictive control formulation for walking motion generation

This article presents a comparison between dense and sparse model predictive control (MPC) formulations, in the context of walking motion generation for humanoid robots. The former formulation leads to smaller, the latter one to larger but more structured optimization problem. We put an accent on the sparse formulation and point out a number of advantages that it presents. In particular, motion generation with variable center of mass (CoM) height, as well as variable discretization of the preview window, come at a negligible additional computational cost. We present a sparse formulation that comprises a diagonal Hessian matrix and has only simple bounds (while still retaining the possibility to generate motions for an omnidirectional walk). Finally, we present the results from a customized code used to solve the underlying quadratic program (QP).
Mechanical Deformation of Polyurethanes

Abstract The mechanical properties of thermoplastic polyurethanes (TPU) depend upon their composition and the complex two‐phase morphologies, which originate from microphase separation of chains segments. In the present work, poly(ether‐urethanes) were prepared with hard segment contents from 36% to 71% by weight, by systematically varying the length of the soft‐segment macrodiol. Samples were prepared by hot pressing or solvent casting, and the resulting hard‐ and soft‐segment morphologies were characterized by using small‐angle x‐ray scattering (SAXS) and transmission electron microscopy (TEM). Environmental scanning electron microscopy (ESEM) was used to study the fracture surfaces of TPU samples. The deformation behavior of the morphology was studied in real time, by using 2‐dimensional SAXS (2D‐SAXS) at the Daresbury synchrotron radiation source. Two distinct mechanisms were identified, with the dominant mechanism in a given material dependent on the copolymer composition and the extent of microphase separation, which developed during processing.
Clinical applications of PD-1-based therapy: a focus on pembrolizumab (MK-3475) in the management of melanoma and other tumor types

Preclinical work has led to an increased understanding of the immunomodulatory mechanisms involved in the regulation of the antitumor response in a variety of tumor types. PD-1 (programmed death 1) appears to be a key checkpoint involved in immune suppression in the tumor microenvironment, even in diseases not previously thought to be sensitive to immune manipulation. More recently, the subsequent clinical development of PD-1-based therapy has resulted in a major breakthrough in the field of oncology. Pembrolizumab, a humanized highly selective IgG4 anti-PD-1 monoclonal antibody, was recently approved for the treatment of advanced melanoma based on promising early-phase clinical data. Encouraging results have also been seen in other malignancies, and PD-1-targeted therapies are likely to markedly change the treatment landscape. Future work will center on rationally designed combination strategies in order to potentiate the antitumor immune response and overcome mechanisms of resistance.
Fabrication, characterization, and evaluation of microsponge delivery system for facilitated fungal therapy

Objective: The rationale behind present research vocation was to develop and investigate a novel microsponge based gel as a topical carrier for the prolonged release and cutaneous drug deposition of fluconazole (FLZ); destined for facilitated fungal therapy. Materials and Methods: Microsponges were prepared using quasi-emulsion solvent diffusion method using Eudragit S-100. In the direction of optimization, the effect of formulation variables (drug-polymer ratio and amount of emulsifier) and diverse factors affecting physical characteristics of microsponge were investigated as well. Fabricated microsponges were characterized by differential scanning calorimetry, Fourier transform-infrared, scanning electron microscopy (SEM), particle size analysis, and also evaluated for drug content, encapsulation efficiency, in vitro drug release and in vitro antifungal activity. Results: Compatibility studies results reflected no sign of any chemical interaction between the drug and polymers used. Whereas, varied drug-polymer ratios and emulsifier concentration indicated significant effect on production yield, drug content, encapsulation efficiency, particle size and drug release. Spherical microsponges with a porous surface and 29.327 ± 0.31 μm mean particle size were evident from SEM micrographs. In vitro release outcomes, from microsponge loaded gels depicted that F1 formulation was more efficient to give extended drug release of 85.38% at the end of 8 h, while conventional formulation by releasing 83.17% of drug got exhausted incredibly earlier at the end of 4 h merely. Moreover, microsponge gels demonstrated substantial spreadability and extrudability along with promising antifungal activity. Conclusions: Fabricated microsponges would be impending pharmaceutical topical carriers of FLZ and a leading alternative to conventional therapy for efficient, safe and facilitated eradication of fungal infections.
Aspirin Intolerance: Experimental Models for Bed-to-Bench

Aspirin is the oldest non-steroidal anti-inflammatory drug (NSAID), and it sometimes causes asthma-like symptoms known as aspirin-exacerbated respiratory disease (AERD), which can be serious. Unwanted effects of aspirin (aspirin intolerance) are also observed in patients with food-dependent exercise-induced anaphylaxis, a type I allergy disease, and aspirin-induced urticaria (AIU). However the target and the mechanism of the aspirin intolerance are still unknown. There is no animal or cellular model of AERD, because its pathophysiological mechanism is still unknown, but it is thought that inhibition of cyclooxygenase by causative agents leads to an increase of free arachidonic acid, which is metabolized into cysteinyl leukotrienes (cysLTs) that provoke airway smooth muscle constriction and asthma symptoms. As the bed-to-bench approach, to confirm the clinical discussion in experimental cellular models, we have tried to develop a cellular model of AERD using activated RBL-2H3 cells, a rat mast cell like cell line. Indomethacin (another NSAID and also causes AERD), enhances in vitro cysLTs production by RBL-2H3 cells, while there is no induction of cysLTs production in the absence of inflammatory activation. Since this suggests that all inflammatory cells with activation of prostaglandin and cysLT metabolism should respond to NSAIDs, and then I have concluded that aspirin intolerance should be separated from subsequent bronchoconstriction. Evidence about the cellular mechanisms of NSAIDs may be employed for development of in vitro AERD models as the approach from bench-to-bed.
Impacts of Highway Snow-Melting Agents on Greening Vegetation

Based on the practice of fight against snow and ice covered on the highway in Liaoning Province which lies in the northeast of china, the research results on the impacts of the highway snow-meting agents on the greening vegetation are shown. Then suggestions to reduce the bad impacts are put forward to provide reference for using scientifically snow-melting agents and protecting environment in the paper.
Cerebrospinal fluid transthyretin: aging and late onset Alzheimer’s disease

The deposition of insoluble β-amyloid protein fibrils is probably the central event in the pathogenesis of Alzheimer’s disease. Cerebrospinal fluid inhibits this fibril formation, likely by the intervention of one or several proteins binding to soluble β-amyloid protein. In vitro, transthyretin (TTR), a CSF protein, impedes amyloid fibrillogenesis. Lowered concentrations of CSFTTR could therefore be associated with Alzheimer’s disease. Concentrations of TTR in CSF samples from 149 consecutive patients were assayed, using a kinetic nephelemetric method. These concentrations were correlated positively with age, but were significantly lower in patients with Alzheimer’s disease. These data raise the possibility that amyloid fibril formation could be promoted in patients with late onset Alzheimer’s disease by the lack of sufficient concentrations of TTR.
KiSS-1, a novel human malignant melanoma metastasis-suppressor gene.

BACKGROUND Microcell-mediated transfer of chromosome 6 into human C8161 and MelJuSo melanoma cell suppresses their ability to metastasize by at least 95% without affecting their tumorigenicity. This observation demonstrates that the ability to metastasize is a phenotype distinct from tumor formation and suggests that tumorigenic cells acquire metastatic capability only after accumulating additional genetic defects. These results also imply that mutations of genes on chromosome 6 are among those late genetic changes responsible for metastatic potential. They further suggest that a melanoma metastasis-suppressor gene(s) is encoded on chromosome 6 or is regulated by genes on chromosome 6. PURPOSE Our objective was to identify the gene(s) responsible for the suppression of metastasis in chromosome 6/melanoma cell hybrids. METHODS A modified subtractive hybridization technique was used to compare the expression of messenger RNAs (mRNAs), via an analysis of complementary DNAs (cDNAs), in metastatic cells (C8161 or MelJuSo) and nonmetastatic hybrid clones (neo6/C8161 or neo6/MelJuSo). RESULTS A novel cDNA, designated KiSS-1, was isolated from malignant melanoma cells that had been suppressed for metastatic potential by the introduction of human chromosome 6. Northern blot analyses comparing mRNAs from a panel of human melanoma cells revealed that KiSS-1 mRNA expression occurred only in nonmetastatic melanoma cells. Expression of this mRNA in normal heart, brain, liver, lung, and skeletal muscle was undetectable by northern blot analysis. Weak expression was found in the kidney and pancreas, but the highest expression was observed in the placenta. The KiSS-1 cDNA encodes a predominantly hydrophilic, 164 amino acid protein with a polyproline-rich domain indicative of an SH3 ligand (binds to the homology 3 domain of the oncoprotein Src) and a putative protein kinase C-alpha phosphorylation site. Transfection of a full-length KiSS-1 cDNA into C8161 melanoma cells suppressed metastasis in an expression-dependent manner. CONCLUSIONS These data strongly suggest that KiSS-1 expression may suppress the metastatic potential of malignant melanoma cells. IMPLICATIONS KiSS-1 may be a useful marker for distinguishing metastatic melanomas from nonmetastatic melanomas.
Transfer of Soy Isoflavone into the Egg Yolk of Chickens

A diet containing a high concentration of soy isoflavone was administered to laying hens and the contents of the isoflavones transferred to the plasma and egg yolk were measured. A method for quantitatively measuring the concentration of isoflavone in the yolk was first established, before a high concentration of soy isoflavone was administered to the laying hens over an 18-day period. The concentrations of isoflavone in the plasma and egg yolk reached their highest on the 12th day of the feeding period, the values being 3,167 nmol/l and 65.29 μg/100g, respectively. The concentration of cholesterol in the yolk was slightly affected during the early stages of the feeding period. These findings clearly demonstrate that soy isoflavone was transferred into the yolk from the feed and that the cholesterol concentration in the yolk was affected by administering the soy isoflavone-enriched feed.
A temporal filter approach for detection and reconstruction of curbs and road surfaces based on Conditional Random Fields

A temporal filter approach for real-time detection and reconstruction of curbs and road surfaces from 3D point clouds is presented. Instead of local thresholding, as used in many other approaches, a 3D curb model is extracted from the point cloud. The 3D points are classified to different parts of the model (i.e. road and sidewalk) using a temporally integrated Conditional Random Field (CRF). The parameters of curb and road surface are then estimated from the respectively assigned points, providing a temporal connection via a Kalman filter.
NCTU-GR: Efficient Simulated Evolution-Based Rerouting and Congestion-Relaxed Layer Assignment on 3-D Global Routing

The increasing complexity of interconnection designs has enhanced the importance of research into global routing when seeking high-routability (low overflow) results or rapid search paths that report wirelength estimations to a placer. This work presents two routing techniques, namely circular fixed-ordering monotonic routing and evolution-based rip-up and rerouting using a two-stage cost function in a high-performance congestion-driven 2-D global router. We also propose two efficient via-minimization methods, namely congestion relaxation by layer shifting and rip-up and reassignment, for a dynamic programming-based layer assignment. Experimental results demonstrate that our router achieves performance similar to the first two winning routers in ISPD 2008 Routing Contest in terms of both routability and wirelength at a 1.05 × and 18.47 × faster routing speed. Moreover, the proposed layer assignment achieves fewer vias and shorter wirelength than congestion-constrained layer assignment (COLA).
A frequency synthesizer using two different delay feedbacks

A phase-locked loop (PLL) with two different delay feedback paths is presented. It provides a new approach to minimize the dead zone, jitter accumulation, long settling time and nonidealities on PFD/CP. This PLL utilizes a tunable delay cell to reduce the ripple on the VCO control line and hence the jitter penalty. In addition, a fully differential delay cell for voltage-controlled oscillator (VCO) is introduced to perform a wide locking range and low-jitter performance. The proposed PLL was implemented in 0.35-/spl mu/m 2P4M CMOS standard technology with the core area of 0.1mm. It can be operated from 250MHz to 1.29GHz and consume 38.2mW of power at 1GHz under a 3.3-V supply voltage.
Grounding Distributional Semantics in the Visual World

Distributional semantic models build vector-based word meaning representations on top of contextual information extracted from large collections of text. Object recognition methods from computer vision derive vector-based representations of visual content from natural images. This article reviews how methods from computer vision are exploited to tackle the fundamental problem of grounding distributional semantic models, bringing them closer to providing a full-fledged computational account of meaning.
A 45nm SOI embedded DRAM macro for POWER7TM 32MB on-chip L3 cache

Logic-based embedded DRAM has matured into a wide range of ASIC applications, SRAM replacements [1] and off-chip caches for microprocessors [2]. While embedded DRAM has been leveraged in supercomputers such as IBM's BlueGene/L [3], it's use has been limited to moderate performance bulk logic technologies. Although prototypes have been demonstrated [4], DRAM has yet to be embedded on a high performance microprocessor. This paper discloses an SOI DRAM macro implemented on-chip with the IBM POWER7™ high performance microprocessor [5], and introduces enhancements to the micro sense amp (µSA) architecture [6]. This high performance DRAM macro is used to construct a large 32MB L3 cache on-chip, eliminating delay, area and power from the off-chip interface, simultaneously improving system performance, reducing cost, power and soft error vulnerability. Figure 19.1. 1a shows an SEM of the 45nm SOI DRAM Device and Deep Trench (DT) capacitor [7]. DT offers 25x more capacitance than planar structures and was also utilized to reduce on-chip voltage island supply noise.
Physical topology discovery for large multisubnet networks

Knowledge of the up-to-date physical (i.e., layer-2) topology of an Ethernet network is crucial to a number of critical network management tasks, including reactive and proactive resource management, event correlation, and root-cause analysis. Given the dynamic nature of today's IP networks, keeping track of topology information manually is a daunting (if not impossible) task. Thus, effective algorithms for automatically discovering physical network topology are necessary. In this paper, we propose the first complete algorithmic solution for discovering the physical topology of a large, heterogeneous Ethernet network comprising multiple subnets as well as (possibly) dumb or uncooperative network elements. Our algorithms rely on standard SNMP MIB information that is widely supported in modern IP networks and require no modifications to the operating system software running on elements or hosts. Furthermore, we formally demonstrate that our solution is complete for the given MIB data; that is, if the MIB information is sufficient to uniquely identify the network topology then our algorithm is guaranteed to recover it. To the best of our knowledge, ours is the first solution to provide such a strong completeness guarantee.
Effects of red ginseng supplementation on menopausal symptoms and cardiovascular risk factors in postmenopausal women: a double-blind randomized controlled trial

ObjectiveThe aim of this study was to evaluate the effects of red ginseng (RG) on menopausal symptoms and cardiovascular risk factors in postmenopausal women. MethodsA randomized, placebo-controlled, double-blind clinical trial was conducted with postmenopausal women between the ages of 45 and 60 years. A total of 72 women were randomly assigned to either an RG group (supplemented with 3 g of RG, including 60 mg of ginsenosides, per day) or a placebo group for 12 weeks. We analyzed changes in menopausal symptoms (the Kupperman index and the menopause rating scale), cardiovascular risk factors (lipid profiles, high-sensitivity C-reactive protein, and carotid intima-media thickness), and serum estradiol levels from baseline to 12 weeks. ResultsSignificant improvements in the Kupperman index (P = 0.032) and in the menopause rating scale (P = 0.035) scores were observed in the RG group compared with the placebo group. Total cholesterol (P = 0.009) and low-density lipoprotein cholesterol (P = 0.015) significantly decreased in the group receiving RG. The RG group also showed a significant decrease in carotid intima-media thickness (P = 0.049). Serum estradiol levels were not influenced by RG supplementation. ConclusionsRG could be an attractive herbal dietary supplement for relieving menopausal symptoms and conferring favorable effects on markers of cardiovascular disease in postmenopausal women.
TV White Space: Solution for bridging the gap between user's demand and the network capacities

This paper aims to offer the results of the analysis of 3G mobile network usage in terms of traffic based on the case of dominant mobile operator in Bosnia and Herzegovina (B&H). By this it is identified whether the demand for more radio spectrum is legitimate. In order to satisfy the requirement for extension of radio spectrum aimed for broadband services the broadcast spectrum (470 - 700 MHz) has been investigated. The rest of the UHF broadcast band (700 - 860 MHz) was not considered since it is specified as the Digital Dividend and hence was not a subject of dynamic access to the spectrum investigation. In addition the "white space" in the TV broadcasting UHF band has been considered as one of the opportunities and challenges for the wireless access network operators. All results have been compared to the relevant researches conducted in some European, US, Asian and African countries. Ultimately the analysis results would help the modernization and enhancement of spectrum management proposing the concept of spectrum sharing and dynamic spectrum access to the national regulatory authority in B&H.
Inhibition by Antiserum to Rat Growth Hormone-Releasing Factor of Growth Hormone Secretion Induced by A Met5-Enkephalin Analog, FK33-824, in Rats 1

Abstract A Met5-enkephalin analog, FK33-824 (5, 10 and 20 ug/100 g body wt, iv) caused a dose-related increase in plasma growth hormone (GH) in urethane-anesthetized male rats. Pretreatmentwith cysteamine (30 mg/100 g body wt, sc), a depletor of hypothalamic somatostatin, increased the plasma GH response to FK33-824 (10 ug/100 g body wt, iv). Antiserum specific for rat GH-releasing factor (GRF)(0.5 ml/rat, iv) blunted GH release induced by FK33-824 (10 ug/100 g body wt, iv) in rats with or without cysteamine pretreatment. These results suggest that GH secretion induced by the opioid peptide is mediated, at least in part, by hypothalamic GRF in the rat.
MicroRNA-18a inhibits ovarian cancer growth via directly targeting TRIAP1 and IPMK

The role of microRNA-18a (miRNA/miR-18a) as a tumor suppressor or promoter in a number of different types of cancer has been reported. However, to date, the expression and the effects of miR-18a in epithelial ovarian cancer (EOC) remain elusive. In the present study, the expression of miR-18a in patient EOC tissues and ovarian cancer cell lines was investigated using the reverse transcription-quantitative polymerase chain reaction. Luciferase assays and western blotting were performed to detect the potential direct targets of miR-18a. An A2780cp intraperitoneal mouse model, and Cell Counting Kit 8, flow cytometry and terminal deoxynucleotidyl-transferase-mediated dUTP nick end labeling assays, were used to investigate the effect of miR-18a on tumor growth in vivo and in vitro. The results indicated that the expression of miR-18a was reduced in EOC tissue and in the investigated ovarian cancer cell lines compared with non-malignant (normal) ovarian tissues and the human ovarian epithelium cell line, respectively. Overexpression of miR-18a in the A2780s and A2780cp cell lines significantly induced cell cycle arrest and apoptosis. It was demonstrated that miR-18a directly targets tumor protein p53-regulating inhibitor of apoptosis gene 1 and inositol phosphate multikinase, hence regulating the expression of downstream targets. The A2780cp intraperitoneal mouse model was employed and the results indicated that miR-18a may inhibit A2780cp intraperitoneal tumor growth in vivo by inhibiting proliferation and inducing apoptosis. Together, the results of the present study demonstrated that miR-18a has a role as a tumor suppressor by inhibiting proliferation and inducing apoptosis. Assessment of miR-18a expression may provide a novel method for diagnosis and be a therapeutic target for EOC.
Group Communication in Partitionable Systems: Specification and Algorithms

Gives a formal specification and an implementation for a partitionable group communication service in asynchronous distributed systems. Our specification is motivated by the requirements for building "partition-aware" applications that can continue operating without blocking in multiple concurrent partitions and can reconfigure themselves dynamically when partitions merge. The specified service guarantees liveness and excludes trivial solutions, it constitutes a useful basis for building realistic partition-aware applications, and it is implementable in practical asynchronous distributed systems where certain stability conditions hold.