Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-term Outcomes after Salvage Stereotactic Radiosurgery (SRS) following In-Field Failure of Initial SRS for Brain Metastases

Purpose The optimal treatment strategy following local recurrence after stereotactic radiosurgery (SRS) remains unclear. While upfront SRS has been extensively studied, few reports focus on outcomes after retreatment. Here, we report the results following a second course of SRS for local recurrence of brain metastases previously treated with SRS. Methods Using institutional database, patients who received salvage SRS (SRS2) following in-field failure of initial SRS (SRS1) for brain metastases were identified. Radionecrosis and local failure were defined radiographically by MRI following SRS2. The primary endpoint was defined as the time from SRS2 to the date of all-cause death or last follow-up [overall survival (OS)]. The secondary endpoints included local failure-free survival (LFFS) and radionecrosis-free survival, defined as the time from SRS2 to the date of local failure or radionecrosis, or last follow-up, respectively. Results Twenty-eight patients with 32 brain metastases were evaluated between years 2004 and 2015. The median interval between SRS1 and SRS2 was 9.7 months. Median OS was 22.0 months. Median LFFS time after SRS2 was 13.6 months. The overall local control rate following SRS2 was 84.4%. The 1- and 2-year local control rates are 88.3% (95% CI, 76.7–100%) and 80.3% (95% CI, 63.5–100%), respectively. The overall rate of radionecrosis following SRS2 was 18.8%. On univariate analysis, higher prescribed isodose line (p = 0.033) and higher gross tumor volume (p = 0.015) at SRS1 were associated with radionecrosis. Although not statistically significant, there was a trend toward lower risk of radionecrosis with interval surgical resection, fractionated SRS, lower total EQD2 (<50 Gy), and lack of concurrent systemic therapy at SRS2. Conclusion In select patients, repeat LINAC-based SRS following recurrence remains a reasonable option leading to long-term survival and local control. Radionecrosis approaches 20% for high risk individuals and parallels historic values.
Procedural Fidelity

A systematic analysis was conducted of measurement and reporting practices related to procedural fidelity in single-case research for the past 30 years. Previous reviews of fidelity primarily reported whether fidelity data were collected by authors; these reviews reported that collection was variable, but low across journals and over time. Results of this review indicate that fidelity data collection was variable across journals, but increasing over time. However, despite previous recommendations for doing so, authors of many studies failed to report when data were collected, for what behaviors, and for which participants. Recommendations include continued fidelity measurement, increased breadth of measurement, increased precision of measurement, and explicit reporting of fidelity data and measurement procedures by authors.
Low Temperature Affects Stem Cell Maintenance in Brassica oleracea Seedlings

Most of the above ground tissues in higher plants originate from stem cells located in the shoot apical meristem (SAM). Several plant species can suffer from spontaneous stem cell arrest resulting in lack of further shoot development. In Brassica oleracea this SAM arrest is known as blindness and occurs in an unpredictable manner leading to considerable economic losses for plant raisers and farmers. Detailed analyses of seedlings showed that stem cell arrest is triggered by low temperatures during germination. To induce this arrest reproducibly and to study the effect of the environment, an assay was developed. The role of genetic variation on the susceptibility to develop blind seedlings was analyzed by a quantitative genetic mapping approach, using seeds from a double haploid population from a cross between broccoli and Chinese kale, produced at three locations. The analysis revealed, besides an effect of the seed production location, a region on linkage group C3 associated with blindness sensitivity. A subsequent dynamic genome-wide transcriptome analysis resulted in the identification of around 3000 differentially expressed genes early after blindness induction. A large number of cell cycle genes were en masse induced early during the development of blindness, whereas shortly after, all were down-regulated. This miss-regulation of core cell cycle genes is accompanied with a strong reduction of cells reaching the DNA replication phase. From the differentially expressed genes, 90 were located in the QTL region C3. Among them are two genes belonging to the MINICHROMOSOMAL MAINTENANCE gene family, known to be involved in DNA replication, a RETINOBLASTOMA-RELATED gene, a key regulator for cell cycle initiation, and several MutS homologs genes, involved in DNA repair. These genes are potential candidates for being involved in the development of blindness in Brassica oleracea sensitive genotypes.
Race Wrestling: Struggling Strategically with Race in Educational Practice and Research

As researchers try to understand, improve, and equalize U.S. schooling, we talk too little about how to study race well. It is particularly crucial, I argue, that researchers struggle to interrogate education’s familiar racial practices more self‐consciously and strategically. I suggest that researchers “race wrestle” by struggling with race on two levels: researchers can (1) learn from the everyday struggles over race already taking place in U.S. schools and (2) struggle more actively with race talk and analysis in our own research. I argue that refocusing analytic attention on everyday struggles over race in educational practice and research is a necessary strategy for moving forward toward racial equality.
Doctoral Students' Access to Research Cultures-are some more unequal than others?

The article explores how different kinds of social science students from two universities, Woodside and Hillside, access and experience a variety of research cultures in those universities. Previous research on research students has noted considerable differences between science and non-science students, with the latter much more likely to work as lone scholars meeting regularly only with their supervisors. Though other researchers have examined academic cultures and their transmission, more generic peer cultures and research training cultures have not always formed part of these studies. The research involved interviews with 26 home and international students, studying both full- and part-time. Four focus group discussions were also conducted. The data suggest that international students and part-time students have the most difficulty in accessing peer cultures and academic cultures. However, international students are much more favourably disposed towards research training cultures than other students. Some evidence of gender differences affecting student experiences was found but was not as widespread as other differences. The article ends by suggesting some practical changes that could be made in universities to provide more equal access to research cultures by all research students.
Do attachment patterns of parents with a mental illness have an impact upon how they view the quality of life of their children?

This study examines the relationship between the attachment patterns of 61 parents with a mental illness and their perception of their children's health-related (QoL). Parental attachment patterns were assessed using the Bielefeld Partnership Expectations Questionnaire (BFPE); health-related QoL of children was measured with the parent version of KINDL-R. Compared to the general population, parents showed different attachment patterns and rated their children's QoL significantly lower overall as well as in the dimensions “emotional well-being”, “friends” and “family”. QoL ratings were associated with specific parental attachment styles. Parents with secure patterns also differed from those with other patterns in their ratings of their children's QoL. These results suggest a role of parental attachment for the perception of child well‐being and functioning. They also underline the need for more research into the association between parent attachment and child well-being in families with mental health problems.
Informing expectations for induction: explorations of attrition among supported beginning secondary science teachers in the United States

Abstract The problem of teacher shortages in many industrialized countries has been the catalyst for the provision of induction programs. The guiding purpose for these programs is to ease the transition from novice to professional and in turn encourage teachers to remain in the profession. This article explores the status of one science-focused induction program in the United States, with particular attention to the expectation that induction programs can help retain beginning teachers. The authors present the context for US induction programs and describe their development. They then examine the cases of eight beginning secondary science teachers who participated in the program but nevertheless chose to leave teaching. Findings indicate that teachers left because they were either out of place in the profession, or they had lost patience with their working conditions. The study broadens our understanding of reasonable expectations for induction programs and, through content analysis and cross-case comparison, examines the needs of the beginning teachers for whom these induction programs are designed.
Abnormal Notochord Branching Is Associated with Foregut Malformations in the Adriamycin Treated Mouse Model

Oesophageal atresia (OA) and tracheooesophageal fistula (TOF) are relatively common human congenital malformations of the foregut where the oesophagus does not connect with the stomach and there is an abnormal connection between the stomach and the respiratory tract. They require immediate corrective surgery and have an impact on the future health of the individual. These abnormalities are mimicked by exposure of rat and mouse embryos in utero to the drug adriamycin. The causes of OA/TOF during human development are not known, however a number of mouse mutants where different signalling pathways are directly affected, show similar abnormalities, implicating multiple and complex signalling mechanisms. The similarities in developmental outcome seen in human infants and in the adriamycin treated mouse model underline the potential of this model to unravel the early embryological events and further our understanding of the processes disturbed, leading to such abnormalities. Here we report a systematic study of the foregut and adjacent tissues in embryos treated with adriamycin at E7 and E8 and analysed between E9 and E12, comparing morphology in 3D in 149 specimens. We describe a spectrum of 8 defects, the most common of which is ventral displacement and branching of the notochord (in 94% of embryos at E10) and a close spatial correspondence between the site of notochord branching and defects of the foregut. In addition gene expression analysis shows altered dorso-ventral foregut patterning in the vicinity of notochord branches. This study shows a number of features of the adriamycin mouse model not previously reported, implicates the notochord as a primary site of disturbance in such abnormalities and underlines the importance of the model to further address the mechanistic basis of foregut congenital abnormalities.
Modularity of cycles and paths in graphs

Certain problems related to the length of cycles and paths modulo a given integer are studied. Linear-time algorithms are presented that determine whether all cycles in an undirected graph are of length <italic>P</italic> mod <italic>Q</italic> and whether all paths between two specified nodes are of length <italic>P</italic> mod <italic>Q</italic>, for fixed integers <italic>P</italic>. <italic>Q</italic>. These results are compared to those for directed graphs.
Practical Field Use of Eye-tracking Devices for Consumer Research in the Retail Environment

Eye-tracking equipment is now affordable and portable, making it a practical instrument for consumer research. Engineered to best analyze gaze on a plane (e.g., a retail shelf), both portable eye-tracking glasses and computer monitor–mounted hardware can play key roles in analyzing merchandise displays to better understand what consumers view. Researchers and practitioners can use that information to improve the sales efficacy of displays. Eye-tracking hardware was nearly exclusively used to investigate the reading process but can now be used for a broader range of study, namely in retail settings. This article presents an approach to using glasses eye tracker (GET) and light eye tracker (LET) eye-tracking hardware for applied consumer research in the field. We outline equipment use, study construction, data extraction as well as benefits and limitations of the technology collected from several pilot studies.
Lyapunov-based Boundary Control for a MIMO Counter-Propagating Raman Amplifier

Abstract This paper considers a boundary feedback control problem for a MIMO counter-propagating Raman amplifier. The system is modeled as a set of coupled semilinear hyperbolic partial differential equations with Lotka-Volterra type nonlinearity. The system is linearized about the steady-state solution, and a boundary controller is designed based on a Lyapunov functional whose time derivative is made strictly negative by an appropriate choice of boundary conditions. As a result, exponential convergence to the steady-state solution is shown in the L2-norm. The results are extended to the nonlinear system under a key assumption.
Intermediate-node initiated reservation (IIR): a new signaling scheme for wavelength-routed networks

A problem of many distributed lightpath provisioning schemes is wavelength contention, which occurs when a connection request attempts to reserve a wavelength channel that is no longer available. This situation results from the lack of updated global link-state information at every node. In networks with highly dynamic traffic loads, wavelength contention may seriously degrade the network performance. To overcome this problem, we propose a new framework for distributed signaling and introduce a class of schemes referred to as intermediate-node initiated reservation. In the new scheme, reservations may be initiated at any set of nodes along the route; in contrast, reservations can only be initiated by the destination node in the classic destination initiated reservation (DIR) scheme. As a result, the possibility of having outdated information due to propagation delay is significantly lowered. Specifically, we consider two schemes within this framework, for networks with no wavelength conversion and for networks with sparse wavelength conversion, respectively. Theoretical and simulation results show that, compared with the classic DIR scheme, the new schemes can significantly improve the network blocking performance. The accuracy of the analytical models is also confirmed by extensive numerical simulations.
Subsystem Congruence

This case study compared the attitudinal behavioral outcomes of participants and nonparticipants involved in strategic cultural change. The research was conducted in a large public organization using the Human Relations Model (i.e., participation -+ satisfaction -+ organization change) to facilitate organization change. It was hypothesized that participants would have higher levels of quality-of-working life than nonparticipants. The results of the study did not support the hypothesis. It appears that a more systemic change process is required in strategic change processes. A discussion of a holistic change model, Subsystem Congruence, is also presented.
Individual Patient Data Subgroup Meta-Analysis of Surgery for Spontaneous Supratentorial Intracerebral Hemorrhage

Background and Purpose— By 2010 there had been 14 published trials of surgery for intracerebral hemorrhage reported in systematic reviews or to the authors, but the role and timing of operative intervention remain controversial and the practice continues to be haphazard. This study attempted to obtain individual patient data from each of the 13 studies published since 1985 to better define groups of patients that might benefit from surgery. Methods— Authors of identified published articles were approached by mail, e-mail, and at conferences and invited to take part in the study. Data were obtained from 8 studies (2186 cases). Individual patient data included patient's age, Glasgow Coma Score at presentation, volume and site of hematoma, presence of intraventricular hemorrhage, method of evacuation, time to randomization, and outcome. Results— Meta-analysis indicated that there was improved outcome with surgery if randomization was undertaken within 8 hours of ictus (P=0.003), or the volume of the hematoma was 20 to 50 mL (P=0.004), or the Glasgow Coma Score was between 9 and 12 (P=0.0009), or the patient was aged between 50 and 69 years (P=0.01). In addition, there was some evidence that more superficial hematomas with no intraventricular hemorrhage might also benefit (P=0.09). Conclusions— There is evidence that surgery is of benefit if undertaken early before the patient deteriorates. This work identifies areas for further research. Ongoing studies in subgroups of patients such as the Surgical Trial in Lobar Intracerebral Hemorrhage (STICH II) will confirm whether these interpretations can be replicated.
Subjective Mood in Young Unmedicated Depressed Women under High and Low Sleep Pressure Conditions

Diurnal mood variations are one of the core symptoms in depression, and total sleep deprivation (SD) can induce rapid, short-lasting clinical improvement in depressed patients. Here, we investigated if differential sleep pressure conditions impact on subjective mood levels in young women with major depressive disorder (MDD) without sleep disturbances, and in healthy controls. Eight healthy and eight MDD women underwent 40-h SD (high sleep pressure) and 40-h multiple NAP (low sleep pressure) protocols under constant routine conditions during which subjective mood was assessed every 30-min. MDD women rated overall significantly worse mood than controls, with minimal values for both groups during the biological night (ca. 4 a.m.), under high and low sleep pressure conditions. During SD, nighttime mood ratings in MDD women were lower than in controls and partially recovered during the second day of SD, but never attained control levels. The degree of this diurnal time-course in mood under SD correlated positively with sleep quality in MDD women. Our data indicate that MDD women without sleep disturbances did not exhibit a SD-induced antidepressant response, suggesting that the mood enhancement response to sleep deprivation might be related to the co-existence of sleep disturbances, which is an association that remains to be fully established.
Effects of Daylight-Saving Time Changes on Stock Market Volatility: A Comment

In a recent article in this journal, Berument, Dogan, and Onar (2010) challenged the existence of the previously documented daylight-saving effect. Kamstra, Kramer, and Levi's original finding (2000) was that average stock market returns on Mondays following time changes are economically and statistically significantly lower than typical Monday returns. Kamstra, et al. hypothesized that the effect may arise due to heightened anxiety or risk aversion on the part of market participants after they experience a 1-hr. disruption in their sleep habits, in accordance with prior findings in the psychology literature linking sleep desynchronosis with anxiety. Berument, et al. replicated the original findings using ordinary least squares estimation, but when they modeled the mean of returns using a method prone to producing biased estimates, they obtained puzzling results. The analysis here, based on standard, unbiased modeling techniques, shows that the daylight-saving effect remains intact in the U.S.
‘Baptism of Fire’: The First Year in the Life of a Newly Qualified Social Worker

This paper describes research commissioned by Skills for Care South West to identify and track the learning and development needs of newly qualified social workers through their first year of employment. The perceptions of 22 newly qualified social workers based in statutory settings are reported concerning the effectiveness of the social work degree (England), their induction and probationary periods and their progress towards post-qualifying social work education as part of their continuing professional development. The perspectives of line managers, people who use services and carers are also discussed. Findings from the research suggest that the social work degree has been well received by most newly qualified social workers and highlights the perceived importance of a statutory placement for social work degree students. Key social work practice skills that require further development are identified and a rationale is presented for greater investment in the induction and probationary periods of newly qualified social workers.
Reflections and Deflections of Policy: The Case of Carol Turner

This article presents a case of Carol, an accomplished second grade teacher who was disposed to teach in ways that seem consistent with the California Mathematics Curriculum Framework. Her approach-grounded in her conceptions of mathematics and her notions about how children learn mathematics—seemed, however, to have been virtually untouched by the policy initiative. Her practice, reflecting glimmers of the new ways, somehow also deflected them. Because the visions of mathematics and mathematical pedagogy represented in the Framework are multiple, Carol could be seen at once as complying with the Framework, or as subtly contradicting it. This raises questions both about the intentions of the Framework and about the nature of this reform. Would a state like California be happy if it could move all teachers to where Carol is? Alternatively, do the state policymakers want to change all teachers-those in the mainstream and on the fringe? The case highlights the complexity of the changes implied by California’s curriculum Framework and the difficulties inherent in communicating those changes in ways that can influence both pedestrian and accomplished practice.
Queering Constructs: Proposing a Dynamic Gender and Sexuality Model

Abstract Higher education educators commonly understand social identities, including gender, to be fluid and dynamic. Lev's (2004) model of four components of sexual identity is commonly used to demonstrate the fluidity of sex, gender, and sexuality for individuals, but it does little to address the fixedness of those constructs. Through a multipronged intersectional framework and by centering trans* -students, this article proposes a more dynamic model for gender and sexuality.
On the Careers of Terminologies; the Case of Bibliometrics

L'usage fait de la neologismes comme descripteurs ou mots-clefs dans le domaine recent de la bibliometrie est etudie de facon a determiner les raisons de leur succes ou de leur echec dans la litterature specialisee. Les revues ARIST, LISA, ISA, LL, le thesaurus d'ERIC et l'Encyclopedie en science de l'information et bibliotheconomie ont ete teste a cette fin