Miracle-dz/UniFAR-FTUs huggingface dataset:
Ship Classification in SAR Images Improved by AIS Knowledge Transfer

A major bottleneck in limiting the application of the existing methods of ship classification in synthetic aperture radar (SAR) images is the inadequate amount of labeled data available for training a classifier. However, generating ground truth involves expensive and time-consuming ground campaigns or is costly, since a high number of SAR image acquisition will be necessary. In contrast, an automatic identification system (AIS), which is an automatic tracking system used for monitoring maritime ships, can provide plenty of labeled ship samples that is relatively easier to be obtained. Inspired by these facts, this letter proposes to improve ship classification in SAR images by transferring AIS knowledge. We propose an improved multiclass adaptive support vector machine, combined with the naive geometric features (NGFs), to achieve transfer learning between the AIS domain and the SAR image domain. The experiments prove that the traditional method can be significantly improved by AIS information transfer, especially when only a few training samples in the SAR domain are available. In addition, it also shows that after feature selection, the performance of the proposed method can be close to that of the state of the art, even if by only using simpler NGFs and few training samples.
The Effects of Hierarchical Micro/Nano-Structured Titanium Surface on Osteoblast Proliferation and Differentiation Under Diabetic Conditions

Purpose: The aim of the present study was to mimic the hierarchical structure of bone tissues by simple sandblasting/acid-etching and anodization to investigate the effects of such surface characteristics on proliferation and differentiation of osteoblasts in high glucose concentrations. By the way, the effects of high glucose levels on osteoblast functions were tested. Methods: MC3T3-E1 cells cultured on sand-blasted and acid-etched (SLA) surface and nano-modified SLA (NMSLA) surface were subjected to normal serum (NS) and diabetic serum (DS), respectively. The surface characteristics were evaluated by scanning electron microscopy. Cell proliferation was assessed using MTT assay. The levels of alkaline phosphatase (ALP) activity and mineralization were measured and compared. Real-time polymerase chain reaction was applied to detect the expression levels of osteogenic genes. Results: NMSLA significantly increased cell proliferation at time points ranging from 3 to 7 days under both serums. Cells cultured on NMSLA surfaces displayed significantly higher ALP activities and mineralization. The expression levels of Runx2 (indicates runt-related protein 2), collagen I (COL1), and osteocalcin (OCN) were notably increased on NMSLA surface compared with SLA surface. Moreover, we found that high glucose increased osteoblast proliferation but decreased differentiation of osteoblast slightly. Conclusion: The hierarchical micro/nano-structured titanium surface has a favorable biocompatibility on simultaneously improving osteoblast proliferation and differentiation in diabetic serum.
Academic procrastination and academic performance: An initial basis for intervention

ABSTRACT Academic procrastination is a prevalent phenomenon with a range of negative outcomes. Many studies focused on causes and correlates of academic procrastination; however, the study of interventions for academic procrastination is scarce. The present study is an initial effort to study the relationship between academic procrastination, online course participation, and achievement, as a basis for developing an intervention for academic procrastination. Findings indicated that studying procrastination was negatively associated with final exam grade as well as with the three online course participation measures. Final exam grade was positively associated with two of the online course participation measures, and they positively correlated with each other. In addition, results indicated that studying procrastination, in combination with online course participation measures, explained about 50% of variance in final exam’s grade. Frequency of activities in course Web site had the strongest positive effect on final exam’s grade. These findings strengthen the notion that studying procrastination is an impediment to students’ academic performance and outcomes and clarifies the need to develop and study academic interventions for academic procrastination as a means to decrease its prevalence in academic settings.
Evolution of pain at 3 months by oral resveratrol in knee osteoarthritis (ARTHROL): protocol for a multicentre randomised double-blind placebo-controlled trial

Introduction Osteoarthritis (OA) pathophysiology is driven in part by joint inflammation. Resveratrol has in vitro anti-inflammatory properties. We aim to assess the efficacy of oral resveratrol for knee pain at 3 months in people with knee OA. Methods and analysis We will conduct a randomised double-blind placebo-controlled trial. Overall, 164 individuals with knee OA fulfilling 1986 American College of Rheumatology criteria will be recruited in three tertiary care centres in France and randomised to receive oral resveratrol, 40 mg (two caplets) two times per day for 1 week, then 20 mg (one caplet) two times per day or a matching placebo for a total of 6 months. Randomisation will be centralised and stratified by centre. The allocation ratio of assignments will be 1:1. The primary outcome will be the mean change from baseline in knee pain on a self-administered 11-point pain Numeric Rating Scale at 3 months. Secondary outcomes will be the mean change in knee pain at 6 months, the function subscore of the Western Ontario and McMaster Universities Arthritis Index score, patient global assessment, proportion of responders according to the Osteoarthritis Research Society International–Outcome Measures in Rheumatology criteria at 3 and 6 months, and self-reported number of intra-articular injections of corticosteroids or hyaluronic acid and consumption of analgesics and non-steroidal anti-inflammatory drugs since the last contact. Other interventions will be allowed and self-reported. Adherence will be monitored by capsule counts and a booklet and adverse events recorded at 3 and 6 months. Statisticians, treating physicians and participants will be blinded to the allocated treatment. Ethics and dissemination The oral resveratrol in knee osteoarthritis (ARTHROL) trial has been authorised by the AgenceNationale de Sécurité du Médicament et des Produits de Santé and ethics were approved by the Comité deProtection des Personnes Île-de-France III. The findings of the study will be published in a peer-reviewed journal and disseminated at conferences. The design of ARTHROL will warrant the translation of its findings into clinical practice. Trial registration number ClinicalTrials.gov identifier: NCT02905799. Pre-results. First received: 14 September 2016. Last updated: 16 September 2016. Status: not yet recruiting.
HydroGraph: Exploring Geographic Data in Graph Databases

Water becomes, every day, more scarce. Reliable informatio n b ut volume and quality in each watershed is important to manageme nt and proper planning of their use. Data-intensive science is being incr easingly needed in this context. Associated analysis processes require handl ing the drainage network that represents a watershed. This paper presents an ongoi ng work that explores geographic watershed data using graph databases – a cal ble and flexible kind of NoSQL databases. The Brazilian Watershed dat abase is used as a case study. The mapping between geographic and graph mode ls is based on the natural network that emerges from the topological rela tionships among geographic entities.
Wrist-based cut-points for moderate- and vigorous-intensity physical activity for the Actical accelerometer in adults

ABSTRACT Wrist-based accelerometers are increasingly used to assess physical activity (PA) in population-based studies; however, cut-points to translate wrist-based accelerometer counts into PA intensity categories are still needed. The purpose of this study was to determine wrist-based cut-points for moderate- and vigorous-intensity ambulatory PA in adults for the Actical accelerometer. Healthy adults (n = 24) completed a four-phase treadmill exercise protocol (1.9, 3.0, 4.0 and 5.2 mph) while wearing an Actical accelerometer on their wrist. Metabolic equivalent of task (MET) levels were assessed by indirect calorimetry. Receiver operating characteristics (ROC) curves were generated to determine accelerometer counts that maximised sensitivity and specificity for classification of moderate (≥3 METs) and vigorous (>6 METs) ambulatory activity. The area under the ROC curves to discriminate moderate- and vigorous-intensity ambulatory activity were 0.93 (95% confidence interval [CI]: 0.90–0.97; P < 0.001) and 0.96 (95% CI: 0.94–0.99; P < 0.001), respectively. The identified cut-point for moderate-intensity ambulatory activity was 1031 counts per minute, which had a corresponding sensitivity and specificity of 85.6% and 87.5%, respectively. The identified cut-point for vigorous intensity ambulatory activity was 3589 counts per minute, which had a corresponding sensitivity and specificity of 88.0% and 98.7%, respectively. This study established intensity-specific cut-points for wrist-based wear of the Actical accelerometer which are recommended for quantification of moderate- and vigorous-intensity ambulatory activity.
Mitochondrial contributions to neuronal development and function

Abstract Mitochondria are critical to tissues and organs characterized by high-energy demands, such as the nervous system. They provide essential energy and metabolites, and maintain Ca2+ balance, which is imperative for proper neuronal function and development. Emerging findings further underline the role of mitochondria in neurons. Technical advances in the last decades made it possible to investigate key mechanisms in neuronal development and the contribution of mitochondria therein. In this article, we discuss the latest findings relevant to the involvement of mitochondria in neuronal development, placing emphasis on mitochondrial metabolism and dynamics. In addition, we survey the role of mitochondrial energy metabolism and Ca2+ homeostasis in proper neuronal function, and the involvement of mitochondria in axon myelination.
Computational Approaches to Chemical Hazard Assessment

Summary Computational prediction of toxicity has reached new heights as a result of decades of growth in the magnitude and diversity of biological data. Public packages for statistics and machine learning make model creation faster. New theory in machine learning and cheminformatics enables integration of chemical structure, toxicogenomics, simulated and physical data in the prediction of chemical health hazards, and other toxicological information. Our earlier publications have characterized a toxicological dataset of unprecedented scale resulting from the European REACH legislation (Registration Evaluation Authorisation and Restriction of Chemicals). These publications dove into potential use cases for regulatory data and some models for exploiting this data. This article analyzes the options for the identification and categorization of chemicals, moves on to the derivation of descriptive features for chemicals, discusses different kinds of targets modeled in computational toxicology, and ends with a high-level perspective of the algorithms used to create computational toxicology models.
Towards a Common Linked Data Model for Sentiment and Emotion Analysis

The different formats to encode information currently in use in sentiment analysis and opinion mining are heterogeneous and often custom tailored to each application. Besides a number of existing standards, there are additionally still plenty of open challenges, such as representing sentiment and emotion in web services, integration of different models of emotions or linking to other data sources. In this paper, we motivate the switch to a linked data approach in sentiment and emotion analysis that would overcome these and other current limitations. This paper includes a review of the existing approaches and their limitations, an introduction of the elements that would make this change possible, and a discussion of the challenges behind that change.
Propionibacterium acnes Enhances the Immunogenicity of HIVBr18 Human Immunodeficiency Virus-1 Vaccine

Immunization of BALB/c mice with HIVBr18, a DNA vaccine containing 18 CD4+ T cell epitopes from human immunodeficiency virus (HIV), induced specific CD4+ and CD8+ T cell responses in a broad, polyfunctional and persistent manner. With the aim of increasing the immunogenicity of this vaccine, the effect of Propionibacterium acnes as an adjuvant was evaluated. The adjuvant effects of this bacterium have been extensively demonstrated in both experimental and clinical settings. Herein, administration of two doses of HIVBr18, in the presence of P. acnes, increased the proliferation of HIV-1-specific CD4+ and CD8+ T lymphocytes, the polyfunctional profile of CD4+ T cells, the production of IFN-γ, and the number of recognized vaccine-encoded peptides. One of the bacterial components responsible for most of the adjuvant effects observed was a soluble polysaccharide extracted from the P. acnes cell wall. Furthermore, within 10 weeks after immunization, the proliferation of specific T cells and production of IFN-γ were maintained when the whole bacterium was administered, demonstrating a greater effect on the longevity of the immune response by P. acnes. Even with fewer immunization doses, P. acnes was found to be a potent adjuvant capable of potentiating the effects of the HIVBr18 vaccine. Therefore, P. acnes may be a potential adjuvant to aid this vaccine in inducing immunity or for therapeutic use.
Second-line ramucirumab therapy for advanced hepatocellular carcinoma (REACH): an East Asian and non-East Asian subgroup analysis

Purpose REACH investigated second-line ramucirumab therapy for advanced hepatocellular carcinoma. Results Median overall survival was 8.2 months for ramucirumab and 6.9 months for placebo (HR, 0.835; 95% CI, 0.634–1.100; p = 0.2046) for East Asians, and 10.1 months for ramucirumab and 8.0 months for placebo (HR, 0.895; 95% CI, 0.690–1.161; p = 0.4023) for non-East Asians. Median overall survival in patients with baseline alpha-fetoprotein ≥ 400 ng/mL was 7.8 months for ramucirumab and 4.2 months for placebo (HR, 0.749; 95% CI, 0.519–1.082; p = 0.1213) for East Asians (n = 139), and 8.2 months for ramucirumab and 4.5 months for placebo (HR, 0.579; 95% CI, 0.371–0.904; p = 0.0149) for non-East Asians (n = 111). The most common grade ≥ 3 treatment-emergent adverse events in East Asians and non-East Asians included hypertension and malignant neoplasm progression. Materials and methods A post-hoc analysis of East Asians (N = 252) and non-East Asians (N = 313) in the intent-to-treat population was performed. Conclusions In East Asians and non-East Asians, ramucirumab did not significantly prolong overall survival. In patients with baseline alpha-fetoprotein ≥ 400 ng/mL, a potentially larger survival benefit was observed in both subgroups. Safety for East Asians was similar to non-East Asians.
Secure Two-Way Communication via a Wireless Powered Untrusted Relay and Friendly Jammer

In this paper, we propose a self-dependent two-way secure communication where two sources exchange confidential messages via a wireless powered untrusted amplify-and-forward (AF) relay and friendly jammer (FJ). By adopting the time switching (TS) architecture at the relay, the data transmission is accomplished in three phases: Phase I) Energy harvesting by the untrusted relay and the FJ through non-information transmissions from the sources, Phase II) Information transmission by the sources and jamming transmissions from the FJ to reduce information leakage to the untrusted relay; and Phase III) Forwarding the scaled version of the received signal from the untrusted relay to the sources. For the proposed system, we derive a new closed-form lower bound expression for the ergodic secrecy sum rate (ESSR). Numerical examples are provided to demonstrate the impacts of different system parameters such as energy harvesting time, transmit signal-to-noise ratio (SNR) and the relay/FJ location on the secrecy performance. The numerical results illustrate that the proposed network with friendly jamming (WFJ) outperforms traditional one-way communication and the two-way without friendly jamming (WoFJ) policy.
Label-Free Detection of Cancer Biomarkers Using an In-Line Taper Fiber-Optic Interferometer and a Fiber Bragg Grating

A compact and label-free optical fiber sensor based on a taper interferometer cascaded with a fiber Bragg grating (FBG) is proposed and experimentally demonstrated for detection of a breast cancer biomarker (HER2). The tapered fiber-optic interferometer is extremely sensitive to the ambient refractive index (RI). In addition, being insensitive to the RI variation, the FBG can be applied as a temperature thermometer due to its independent response to the temperature. Surface functionalization to the sensor is carried out to achieve specific targeting of the unlabeled biomarkers. The result shows that the proposed sensor presents a low limit-of-detection (LOD) of 2 ng/mL, enabling its potentials of application in early diagnosis on the breast cancer.
Modeling Shape and Rupture of Filament Networks

The actin cytoskeleton is a biopolymer network that provides spatial coordination and mechanical strength to biological cells. Due to the asymmetric mechanical response of polymers under tension versus compression, it behaves like a mechanical network of cables. In addition, it actively contracts through the continuous action of myosin molecular motors. Here we investigate theoretical models on the cellular scale which incorporate these special properties. In the first part of this work we model cells adherent to discrete adhesion sites on planar surfaces. We compare the shape and force distribution in contracted networks of Hookean springs and cables. We find that only active cable networks can correctly predict the experimentally observed cell shape. In the second part we apply the active cable network to experimental data. We combine this model with contractile actin bundles and find that this combination leads to surprisingly good predictions for the traction force pattern of adherent cells on soft elastic substrates. Because cellular forces can lead to failure of the network, in the third part we investigate bond rupture in mechanical networks. Here, bonds stochastically rupture with rates that grow exponentially with force. We study the statistical properties of networks under constant strain and strain which linearly increases in time. The results are compared to traditional fracture mechanics which are dominated by stability thresholds.
Institutions and the Resource Curse

Countries rich in natural resources constitute both growth losers and growth winners. We claim that the main reason for these diverging experiences is differences in the quality of institutions. More natural resources push aggregate income down, when institutions are grabber friendly, while more resources raise income, when institutions are producer friendly. We test this theory building on Sachs and Warner's influential works on the resource curse. Our main hypothesis: that institutions are decisive for the resource curse, is confirmed. Our results are in sharp contrast to the claim by Sachs and Warner that institutions do not play a role.
Immunological Profile of Periapical and Periodontal Lesions: Current Concepts in the Role of T Cells

Periapical lesions of endodontic origin and periodontitis are the two common chronic conditions that constitute the immunoinflammatory responses to putative oral pathogens. Both the conditions encompass similar patterns of development and pathologic mechanisms of host-mediated tissue destruction and subsequent establishment of the lesion. This host inflammatory response is attributed to a large array of immune cells that play a regulatory role in the protective and destructive pathways culminating in these two diseases. Hence, knowledge of the host response involved in their pathogenesis is essential to comprehend the disease process and thus aid in establishing proper therapeutic strategies to keep the host response under control. This review will focus on the pivotal role played by the T cells and its various subsets, namely the T helper (Th)1, Th2, Th17, Treg, Th22, and Th9, and elicit deeper insights on the Th1/Th2 and the Th17/Treg paradigm.
Effect of Physician it Use on Practice Performance

The role of information technology (IT) remains important within the medical community. However, little is known about the extent to which practicing physicians improve practice performance by having and utilizing IT at the national level. The present study, analyzing a national physician survey (n = 4,720), seeks to explore associations of IT availability and utilization with practice performance at the national level. The multivariate regression analysis results suggest that patient information IT functionality upholds physician advantages in annual income but prescription drug IT functionality was reversely linked to annual income. We also found a negative association of patient information IT functionality with patient visit volume. Our study results revealed mixed findings. Not all IT functionalities would offer benefits to practicing physicians. Our data suggest that patient information IT functionality can moderate cost concerns related to IT investment among providers.
Cognitive Remediation in Middle-Aged or Older Inpatients with Chronic Schizophrenia: A Randomized Controlled Trial in Korea

Background: Accumulating evidence indicates that cognitive remediation (CR) is effective for improving various cognitive deficits in adult patients with schizophrenia. Although reports of brain plasticity in older adults and the service needs for chronic patients with schizophrenia are increasing, very few randomized controlled trials of CR have been conducted in middle-aged or older inpatients with chronic schizophrenia. We investigated the efficacy of individualized CR on the cognitive impairments of middle-aged or older inpatients with chronic schizophrenia within the context of comprehensive psychiatric rehabilitation (PR) by comparing the results obtained with PR only and treatment as usual (TAU). Method: Fifty-seven middle-aged and older individuals with chronic schizophrenia and mild to moderate cognitive deficits were enrolled. Thirty-eight who were undergoing PR were randomly assigned to CR + PR (N = 19) or PR-only (N = 19) groups. Nineteen participants who were undergoing TAU without CR or PR were evaluated pre- and post-treatment. Results: CR was easily provided and well received (drop-out rates = 5.3%) by middle-aged or older psychiatric inpatients. Compared to the PR-Only or TAU patients, patients in the CR + PR group showed greater improvement in executive functioning. Compared to TAU patients, CR + PR and PR-only patients showed greater improvement in logical memory. More patients in the CR + PR group improved clinically significantly in executive functioning and logical memory, compared with the PR-only and TAU patients. Conclusions: These results suggested that CR improved some cognitive deficits in middle-aged or older inpatients with chronic schizophrenia and that it was effective as an adjunctive treatment to the usual PR services provided in inpatient settings. Clinical Registration: KCT0002609