Miracle-dz/UniFAR-FTUs huggingface dataset:
Citation for Published Item: Use Policy Differential and Co-involvement of Areas of the Temporal and Parietal Streams in Visual Tasks

The full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that: • a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders. Please consult the full DRO policy for further details. Abstract Transcranial magnetic stimulation (TMS) is particularly useful in teasing apart the contrasting contributions of different anatomical and functional systems in particular aspects of behaviour, for example the involvement of the dorsal and ventral visual streams in tasks involving the perception of distance, shape and colour. In order to investigate the dual involvement of two areas, namely right posterior parietal cortex (PPC) and lateral occipital cortex (LO), in a distance discrimination task, neural processing in both areas was concurrently disrupted using dual site TMS. Although there was no change in error rates, reaction time was significantly lengthened over that seen with TMS over either site alone. This additive effect indicates that both PPC and LO are concurrently active and essential for efficient processing of this task. The second experiment investigated the specificity of function within the ventral stream. Performance was assessed for distance and shape discrimination when TMS was applied to our original LO site and an area rostral to V5 but still part of the lateral occipital complex (rostral LOC) that is activated in form and colour discrimination. Performance deficits were restricted to TMS over LO; no significant impairment for either task followed TMS at the rostral LOC site.
Crypanalysis of Kuo and Chen's Threshold Proxy Signature Scheme Based on the RSA

In a (t,n) threshold proxy signature scheme, an original signer delegates a group of n proxy signers to sign messages on behalf of him or her. When the proxy signature is created, t or more proxy signers cooperate to generate valid proxy signatures and any less than t proxy signers can't cooperatively produce valid proxy signatures. In 2003, Hwang et al. proposed a practical threshold proxy signature scheme (HLL-scheme) which is based on RSA crypto system for the first time. In 2004, Wang et al. had provided some comments on HLL-scheme. They showed that some mistakes of equations had made HLL-scheme become insecure. Moreover, in 2005, Kuo and Chen also showed two security weaknesses in Hwang et al.'s scheme: one is similar to RSA reblocking problem and the other is that the value of Li is not clearly defined. In addition, to overcome the second shortcoming of HLL-scheme, Kuo and Chen also provided a modified threshold proxy signature scheme (KC-scheme) based on HLL-scheme. By observation, we find that KC-scheme cannot still work. In other words, in KC-scheme, the value of Li cannot still be worked out, as makes KC-scheme not workable. To design a workable threshold proxy signature scheme, based on KC-scheme, an improved scheme is proposed
Role of Osteogenic Growth Peptide (OGP) and OGP(10–14) in Bone Regeneration: A Review

Bone regeneration is a process that involves several molecular mediators, such as growth factors, which directly affect the proliferation, migration and differentiation of bone-related cells. The osteogenic growth peptide (OGP) and its C-terminal pentapeptide OGP(10–14) have been shown to stimulate the proliferation, differentiation, alkaline phosphatase activity and matrix mineralization of osteoblastic lineage cells. However, the exact molecular mechanisms that promote osteoblastic proliferation and differentiation are not completely understood. This review presents the main chemical characteristics of OGP and/or OGP(10–14), and also discusses the potential molecular pathways induced by these growth factors to promote proliferation and differentiation of osteoblasts. Furthermore, since these peptides have been extensively investigated for bone tissue engineering, the clinical applications of these peptides for bone regeneration are discussed.
Multiparametric MRI and CT Models of Infarct Core and Favorable Penumbral Imaging Patterns in Acute Ischemic Stroke

Background and Purpose— Objective imaging methods to identify optimal candidates for late recanalization therapies are needed. The study goals were (1) to develop magnetic resonance imaging (MRI) and computed tomography (CT) multiparametric, voxel-based predictive models of infarct core and penumbra in acute ischemic stroke patients, and (2) to develop patient-level imaging criteria for favorable penumbral pattern based on good clinical outcome in response to successful recanalization. Methods— An analysis of imaging and clinical data was performed on 2 cohorts of patients (one screened with CT, the other with MRI) who underwent successful treatment for large vessel, anterior circulation stroke. Subjects were divided 2:1 into derivation and validation cohorts. Pretreatment imaging parameters independently predicting final tissue infarct and final clinical outcome were identified. Results— The MRI and CT models were developed and validated from 34 and 32 patients, using 943 320 and 1 236 917 voxels, respectively. The derivation MRI and 2-branch CT models had an overall accuracy of 74% and 80%, respectively, and were independently validated with an accuracy of 71% and 79%, respectively. The imaging criteria of (1) predicted infarct core ⩽90 mL and (2) ratio of predicted infarct tissue within the at-risk region ⩽70% identified patients as having a favorable penumbral pattern with 78% to 100% accuracy. Conclusions— Multiparametric voxel-based MRI and CT models were developed to predict the extent of infarct core and overall penumbral pattern status in patients with acute ischemic stroke who may be candidates for late recanalization therapies. These models provide an alternative approach to mismatch in predicting ultimate tissue fate.
Investigating the Encoding Process of Transactive Memory Development in Group Training

Participants were trained to perform an assembling type of task either individually or in 3-person groups. A week later, the same participants, regardless of their training conditions, performed the task in 3-person groups. This study investigated the encoding process of transactive memory development in groups whose members were trained together and that were later found to have developed effective transactive memory systems. Transactive memory is a group memory system that details the expertise possessed by group members along with an awareness of who knows what within the group. It was found that in groups with high transactive memory, (a) group members declared domains of expertise during earlier rather than later periods of group interaction, and (b) the frequency with which members evaluated others’ expertise and competence increased over time. Further analyses of sequential patterns of conversations during group training and practice suggested that transactive encoding may include small cycles of questioning/ no expertise/declaring expertise/evaluating/coordinating.
Expression by Soil Bacteria of Nodulation Genes from Rhizobium leguminosarum biovar trifolii

Gram-negative, rod-shaped bacteria from the soil of white clover-ryegrass pastures were screened for their ability to nodulate white clover (Trifolium repens) cultivar Grasslands Huia and for DNA homology with genomic DNA from Rhizobium leguminosarum biovar trifolii ICMP2668 (NZP582). Of these strains, 3.2% were able to hybridize with strain ICMP2668 and nodulate white clover and approximately 19% hybridized but were unable to nodulate. Strains which nodulated but did not hybridize with strain ICMP2668 were not detected. DNA from R. leguminosarum biovar trifolii (strain PN165) cured of its symbiotic (Sym) plasmid and a specific nod probe were used to show that the relationship observed was usually due to chromosomal homology. Plasmid pPN1, a cointegrate of the broad-host-range plasmid R68.45 and a symbiotic plasmid pRtr514a, was transferred by conjugation to representative strains of nonnodulating, gram-negative, rod-shaped soil bacteria. Transconjugants which formed nodules were obtained from 6 of 18 (33%) strains whose DNA hybridized with that of PN165 and 1 of 9 (11%) strains containing DNA which did not hybridize with that of PN165. The presence and location of R68.45 and nod genes was confirmed in transconjugants from three of the strains which formed nodules. Similarly, a pLAFR1 cosmid containing nod genes from a derivative of R. leguminosarum biovar trifolii NZP514 formed nodules when transferred to soil bacteria.
Social Inclusion in Community Sport: A Case Study of Muslim Women in Australia

This paper considers how organizational practices facilitate and inhibit the social inclusion of Muslim women in a community sport setting. A case study of social inclusion practices in an Australian community sport organization (CSO) was built through interviews, focus groups, secondary data, and documentary evidence. Drawing on the work of Bailey (2005, 2008) the analysis employed a social inclusion framework comprised of spatial, functional, relational, and power dimensions. Findings indicated that there are a range of practices which facilitate social inclusion. Paradoxically, some of the practices that contributed to social inclusion at the club for Muslim women resulted in social exclusion for non-Muslim women. Examining each practice from multiple perspectives provided by the social inclusion framework allowed a thorough analysis to be made of the significance of each practice to the social inclusion of Muslim women at the club. Implications for social inclusion research and sport management practice are discussed.
Fostering Interorganizational Linkages in the Canadian Sport Delivery System

The purpose of this paper is to examine the nature and extent of interorganizational linkages between the partners involved in Canada's sport delivery system. Given the changes in the economic context of the 1990s and the ensuing fiscal restraints exercised by both government and the private sector, amateur sport organizations are in a period of high uncertainty. In order to deal with this uncertainty, links between organizations like governments, nonprofit sport organizations, and private sector organizations need to be established, fostered, and maintained. Organizations need to collaborate with each other in order to fulfill their objectives. Linkages between organizations will assist in the sharing of resources and in the coordination of work-related activities. In the paper, a number of examples of existing links between governments, nonprofit organizations, and private organizations are presented. Based on resource dependency theory, strategies such as contracts, joint ventures, and co-optation for .
Acta Universitatis Upsaliensis Uppsala 2014

Häggblad Sahlberg, S. 2014. Colorectal cancer and radiation response. The role of EGFR, AKT and cancer stem cell markers. The primary treatment for colorectal cancer is surgery. Radiotherapy and chemotherapy, sometimes combined, are also frequently used to diminish recurrence risk. In response to radiation exposure, several cellular signaling cascades are activated to repair DNA breaks, prevent apoptosis and to keep the cells proliferating. Several proteins in the radiation response and cell survival pathways are potential targets to enhance the effects of radiation. The epidermal growth factor receptor (EGFR), which is frequently upregulated in colorectal cancer and exhibits a radiation protective function, is an attractive target for treatment. EGFR is activated by radiation which in turn activates numerous signaling pathways such as the PI3 kinase/AKT cascade, the RAS/RAF/ERK pathway and STAT leading to tumor cell proliferation. EGFR is also believed to interact with proteins in the DNA repair process, such as DNA-PKcs and MRE11. The cytotoxic effect of an affibody molecule (Z EGFR:1907) 2 , with high affinity to EGFR, in combination with radiation produced a small, but significant, reduction in survival in a KRAS mutated cell line. However, not in the BRAF mutated cell line. The next step was therefore to target proteins downstream of EGFR such as AKT. There was an interaction between AKT and the DNA repair proteins DNA-PKcs and MRE11 and both AKT1 and AKT2 were involved in the radiation response. The knockout of both AKT isoforms impaired the DNA double strand break rejoining after radiation and suppression of DNA-PKcs increased the radiations sensitivity and decreased the DNA repair further. The AKT isoforms also affected the expression of cancer stem cell markers CD133 and CD44 which are associated with the formation of metastasis as well as radiation and drug resistance. The CD133 expression was associated with AKT1 but not AKT2, whereas the CD44 expression was influenced by the presence of either AKT1 or AKT2. AKT was also involved in cell migration, cell-adhesion and metabolism. Overall, these results illustrate the complexity in response to radiation and drugs in cells with different mutations and the need for combining inhibitors against several targets such as EGFR, AKT, DNA-PKcs, CD133 or CD44. To my supportive family and friends List of Papers This thesis is based on the following papers, which are referred to in the text by their Roman numerals. The effect of a dimeric Affibody molecule (Z EGFR:1907) 2 targeting …
Activation of the Insulin Receptor by Insulin and a Synthetic Peptide Leads to Divergent Metabolic and Mitogenic Signaling and Responses*

Recently, single chain peptides have been designed that target the insulin receptor and mimic insulin action. The aim of this study is to explore if activation of the insulin receptor with such an optimized peptide (S597) leads to the same activation of signaling pathways and biological endpoints i.e. stimulation of glycogen synthesis and cell proliferation as stimulation with insulin. We find that surface activation of the insulin receptor A-isoform with S597 leads to activation of protein kinase B (PKB) and glycogen synthesis comparable to activation by insulin, even though the level of insulin receptor phosphorylation is lower. In contrast, both Src homology 2/α collagen-related (Shc) and extracellular signal-regulated kinase (ERK) 2 activation are virtually absent upon stimulation with S597. Cell proliferation is only stimulated slightly by S597, suggesting that it depends on signals from Shc and ERK. The differences in signaling response could explain both the earlier reported differences in gene expression, and the reported differences in cell proliferation and glycogen synthesis induced by insulin and S597. In conclusion, despite binding equipotency, insulin, and S597 initiate different signaling and biological responses through the same insulin receptor isoform. We show for the first time that it is possible to design insulin receptor ligand mimetics with metabolic equipotency but low mitogenicity.
Short stature and obesity: positive association in adults but inverse association in children and adolescents

Shorter than average adults are at a higher risk for obesity and are also more susceptible to diabetes and CVD, independent of BMI. In contrast, taller children have a higher risk of obesity. We hypothesised that short stature is related to adverse body composition and that the association between stature and obesity differs between generations. In a cross-sectional German database of 213 804 adults and 12 411 children and adolescents, the prevalence of overweight and obesity was compared between percentiles of height. The association between stature and percentage of fat mass (%FM), lean BMI (LBMI; kg/m2) or waist:hip ratio (in children only) was analysed within BMI groups. In adults, the prevalence of BMI >30 kg/m2 gradually increased with decreasing percentile of height whereas in children and adolescents, a positive association between height and weight status was observed. Short-stature women and girls had a 0·8–3·2 % lower %FM than tall subjects (P < 0·05), whereas no trend for %FM was observed in males. When compared with tall subjects, LBMI was 0·2–0·6 kg/m2 lower in short-stature men, as well as obese women (P < 0·05). There was a non-significant trend for a lower LBMI and a higher waist:hip ratio in shorter children. In conclusion, short stature is associated with an increased risk of obesity in adults. Cardiometabolic risk in short stature is not explained by an adverse body composition.
Facial Expression Recognition with Relevance Vector Machines

For many decades automatic facial expression recognition has scientifically been considered a real challenging problem in the fields of pattern recognition or robotic vision. The current research aims at proposing relevance vector machines (RVM) as a novel classification technique for the recognition of facial expressions in static images. The aspects related to the use of Support Vector Machines are also presented. The data for testing were selected from the Cohn-Kanade facial expression database. We report 90.84% recognition rates for RVM for six universal expressions based on a range of experiments. Some discussions on the comparison of different classification methods are included
Influence of topography and hydrophilicity on initial oral biofilm formation on microstructured titanium surfaces in vitro.

OBJECTIVES The aim of this study was to analyse the influence of the microtopography and hydrophilicity of titanium (Ti) substrates on initial oral biofilm formation. MATERIALS AND METHODS Nine bacterial species belonging to the normal oral microbiota, including: Aggregatibacter actinomycetemcomitans, Actinomyces israelii, Campylobacter rectus, Eikenella corrodens, Fusobacterium nucleatum, Parvimonas micra, Porphyromonas gingivalis, Prevotella intermedia, and Streptococcus sanguinis were tested on Ti surfaces: pretreatment (PT [R(a) <0.2 μm]), acid-etched (A [R(a) <0.8 μm]), A modified to be hydrophilic (modA), sand-blasted/acid-etched (SLA [R(a) =4 μm]), and hydrophilic SLA (modSLA). Disks were incubated for 24 h in anaerobic conditions using a normal culture medium (CM) or human saliva (HS). The total counts of bacteria and the proportion of each bacterial species were analysed by checkerboard DNA-DNA hybridization. RESULTS Higher counts of bacteria were observed on all surfaces incubated with CM compared with the samples incubated with HS. PT, SLA, and modSLA exhibited higher numbers of attached bacteria in CM, whereas SLA and modSLA had a significant increase in bacterial adhesion in HS. The proportion of the species in the initial biofilms was also influenced by the surface properties and the media used: SLA and modSLA increased the proportion of species like A. actinomycetemcomitans and S. sanguinis in both media, while the adhesion of A. israelii and P. gingivalis on the same surfaces was affected in the presence of saliva. CONCLUSIONS The initial biofilm formation and composition were affected by the microtopography and hydrophilicity of the surface and by the media used.
Gene regulatory networks and developmental plasticity in the early sea urchin embryo: alternative deployment of the skeletogenic gene regulatory network

Cell fates in the sea urchin embryo are remarkably labile, despite the fact that maternal polarity and zygotic programs of differential gene expression pattern the embryo from the earliest stages. Recent work has focused on transcriptional gene regulatory networks (GRNs) deployed in specific embryonic territories during early development. The micromere-primary mesenchyme cell (PMC) GRN drives the development of the embryonic skeleton. Although normally deployed only by presumptive PMCs, every lineage of the early embryo has the potential to activate this pathway. Here, we focus on one striking example of regulative activation of the skeletogenic GRN; the transfating of non-skeletogenic mesoderm (NSM) cells to a PMC fate during gastrulation. We show that transfating is accompanied by the de novo expression of terminal, biomineralization-related genes in the PMC GRN, as well as genes encoding two upstream transcription factors, Lvalx1 and Lvtbr. We report that Lvalx1, a key component of the skeletogenic GRN in the PMC lineage, plays an essential role in the regulative pathway both in NSM cells and in animal blastomeres. MAPK signaling is required for the expression of Lvalx1 and downstream skeletogenic genes in NSM cells, mirroring its role in the PMC lineage. We also demonstrate that Lvalx1 regulates the signal from PMCs that normally suppresses NSM transfating. Significantly, misexpression of Lvalx1 in macromeres (the progenitors of NSM cells) is sufficient to activate the skeletogenic GRN. We suggest that NSM cells normally deploy a basal mesodermal pathway and require only an Lvalx1-mediated sub-program to express a PMC fate. Finally, we provide evidence that, in contrast to the normal pathway, activation of the skeletogenic GRN in NSM cells is independent of Lvpmar1. Our studies reveal that, although most features of the micromere-PMC GRN are recapitulated in transfating NSM cells, different inputs activate this GRN during normal and regulative development.
Pragmatic Perspectives on the Measurement of Information Systems Service Quality

In this research note, we join the debate between Van Dyke, Kappelman, and Prybutok, and Pitt, Watson, and Kavan pertaining to the conceptual and empirical relevance of SERVQUAL as a measure of IS service quality. Adopting arguments from marketing, Van Dyke et al. (1997) question the SERVQUAL gap measurement approach, the interpretation and operationalization of the SERVQUAL expectation construct, and the reliability and validity of SERVQUAL dimensionality. In a response to those arguments, Pitt et al. (1997) defend their previous work (1995) in a point-by- point counterargument that suggests that the marginal empirical benefit of a perceptual-based (SERVPERF) service quality measure does not justify the loss of managerial diagnostic capabilities found in a gap measure. While siding with many of the positions taken by Pitt et al., we attempt to add value to the debate by presenting discrepancies we have with the two other research teams and by suggesting alternative approaches to resolve, or at least alleviate, problems associated with SERVQUAL. We believe that the theoretical superiority of an alternative IS service quality measure should be backed by empirical evidence in the IS context, hence, answering some of the criticism Van Dyke et al. and by offering a construct valid version of the IS-adapted SERVQUAL. From a pragmatic viewpoint, we believe that the justification of using SERVQUAL's gap measure should be driven by more effective ways to utilize expectations in IS service management. To this end, we introduce the newer Parasuraman et al. (1994b) measures, the concept of a "zone of tolerance" for expectation management and an illustration of its practical use in an IS setting. Overall, we attempt to set the direction of where we think this debate should lead the IS field, namely, toward practical and timely IS service quality measures.
Universals in cognitive theories of language

Abstract Generative linguistics' search for linguistic universals (1) is not comparable to the vague explanatory suggestions of the article; (2) clearly merits a more central place than linguistic typology in cognitive science; (3) is fundamentally untouched by the article's empirical arguments; (4) best explains the important facts of linguistic diversity; and (5) illuminates the dominant component of language's “biocultural” nature: biology.