Miracle-dz/UniFAR-FTUs huggingface dataset:
Cognitive-behavioral group therapy for panic disorder in the general clinical setting: a naturalistic study with 1-year follow-up.

BACKGROUND Cognitive-behavioral therapy (CBT) is well documented in the treatment of panic disorder. As most investigators have studied selected patients without comorbid disorders, it is less clear how well the treatment will perform in the usual clinical setting for patients with comorbid disorders and with physicians who do not have training in CBT. During the last 6 years, we have offered CBT in outpatient groups for patients with panic disorder and agoraphobia. The purpose of this prospective study was to assess the outcome of group treatment and compare the results with those of studies that used individual treatment. We wanted to identify variables that might predict outcome at follow-up and to assess the number and characteristics of dropouts. METHOD Eighty-three consecutive patients with DSM-III-R panic disorder (56 women and 27 men; mean age = 34.5 years) were studied. Mean duration of panic disorder was 7.5 years. There was a high degree of comorbid major depression, social phobia, and psychoactive substance abuse/dependence. Treatment consisted of 4-hour group sessions conducted once a week for 11 weeks. More than half of the patients used antidepressant drugs. Degree of phobic avoidance, bodily sensations, anxiety cognitions, and depression were assessed at pretreatment, baseline, and end of treatment and at follow-up after 3 and 12 months. RESULTS There was a large decrease in scores from start to end on all assessments. Sixty-three (89%) of 73 completers responded (> or = 50% reduction in Phobic Avoidance Rating Scale scores). Gains were maintained and even improved upon at follow-up. The results are comparable with studies that used individual therapy. A high depression score at the end of treatment predicted poor outcome at 1-year follow-up. Twelve (14%) of 83 did not complete the program. The presence of severe personality disorders and ongoing alcohol or substance abuse or dependence was associated with poor outcome and high dropout rate. CONCLUSION CBT appears to be effective in the usual clinical setting, even in the hands of therapists without formal competence. Group therapy is a feasible arrangement, and the results from group treatment are comparable to those of individual approaches. Precise diagnosis and treatment of comorbid depression are of utmost importance. Patients with additional substance abuse or dependence, as well as severe personality disorders, may find this treatment modality less helpful.
Identification of QTLs for yield and yield components of barley under different growth conditions

Waterlogging is a major abiotic stress limiting barley (Hordeum vulgare L.) yield and its stability in areas with excessive rainfall. Identification of genomic regions influencing the response of yield and its components to waterlogging stress will enhance our understanding of the genetics of waterlogging tolerance and the development of more tolerant barley cultivars. Quantitative trait loci (QTLs) for grain yield and its components were identified using 156 doubled haploid (DH) lines derived from a cross between the cultivars Yerong (waterlogging-tolerant) and Franklin (waterlogging-sensitive) grown under different conditions (waterlogged and well drained). A total of 31 QTLs were identified for the measured characters from two experiments with two growth environments. The phenotypic variation explained by individual QTLs ranged from 4.74% to 55.34%. Several major QTLs determining kernel weight (KW), grains per spike (GS), spikes per plant (SP), spike length (SL) and grain yield (GY) were detected on the same region of chromosome 2H, indicating close linkage or pleiotropy of the gene(s) controlling these traits. Some different QTLs were identified under waterlogging conditions, and thus different markers may have to be used in selecting cultivars suitable for high rainfall areas.
A Novel C-terminal Motif Is Necessary for the Export of the Vasopressin V1b/V3 Receptor to the Plasma Membrane*

Little is known about endoplasmic reticulum (ER) export signals, particularly those of members of the G-protein-coupled receptor family. We investigated the structural motifs involved in membrane export of the human pituitary vasopressin V1b/V3 receptor. A series of V3 receptors carrying deletions and point mutations were expressed in AtT20 corticotroph cells. We analyzed the export of these receptors by monitoring radioligand binding and by analysis of a V3 receptor tagged with both green fluorescent protein and Myc epitopes by a novel flow cytometry-based method. This novel method allowed us to quantify total and membrane-bound receptor expression. Receptors lacking the C terminus were not expressed at the cell surface, suggesting the presence of an export motif in this domain. The distal C terminus contains two di-acidic (DXE) ER export motifs; however, mutating both these motifs had no effect on the V3 receptor export. The proximal C terminus contains a di-leucine 345LL346 motif surrounded by the hydrophobic residues Phe341, Asn342, and Leu350. The mutation of one or more of these five residues abolished up to 100% of the receptor export. In addition, these mutants colocalized with calnexin, demonstrating that they were retained in the ER. Finally, this motif was sufficient to confer export properties on a CD8α glycoprotein-V3 receptor chimera. In conclusion, we have identified a novel export motif, FN(X)2LL(X)3L, in the C terminus of the V3 receptor.
Two Processes Regulating Trophic Energy Flow in Pelagic and Terrestrial Ecosystems: Trophic Efficiency and Body Size–Dependent Biomass Production: (A Reply to Giacomini)

We proposed two hypotheses to explain why food chains are longer in pelagic than terrestrial ecosystems: greater trophic efficiency of pelagic animal taxa at lower trophic levels and a higher pelagic biomass production rate at lower trophic levels because of smaller pelagic body masses. Giacomini favored the former, invoking in support the energetic equivalence hypothesis. We reply that the energetic equivalence hypothesis does not describe populations at differing trophic levels and so does not refute a significant role for body-mass dependence in explaining faster trophic transfer in pelagic ecosystems. Metabolic scaling as body mass to the exponent 1/4, widely accepted, remains important for trophic dynamic models. We suggest a likelihood method to compare the two hypotheses on the basis of models of whole-ecosystem energetics.
[Phosphorus dissolving capability, glucose dehydrogenase gene expression and activity of two phosphate solubilizing bacteria].

Objective To identify the function of glucose dehydrogenase (GDH) and gene expression level in the process of solubilizing phosphorus. Methods Phosphate solubilizing bacteria (PSB) were isolated and purified by soluble phosphorus circle method, and identified by Vitek 2 system and 16S rRNA sequence. The phosphate solubilization capacity and GDH activity of PSB were determined. GDH genes were cloned by PCR and the relative expression level of both genes under different conditions were determined by real-time quantitative PCR. Results Two PSB were identified as Pseudomonas sp. and Enterobacter sp. and the highest phosphorus solubilizing capability was 558 μg/mL for the former and 478 μg/mL for the latter. GDH genes of the two bacteria were cloned and the fragments were 2007 bp and 2066 bp. Different GDH activity and GDH gene expression were cultivated under the condition of different phosphorus sources and pH value. GDH gene expression of strain wj1 was higher than the other under high phosphorus, and the result was opposite under phosphorus stress. However, GDH gene expression of strain wj3 was lower in all phosphorus levels. The expression of GDH gene and the change of the enzyme activity were not obviously related with phosphorus solubilizing capability for strain wj3. Conclusion There were different characteristics of GDH activity and GDH gene expression in two isolated strains that have different phosphate solubilizing mechanisms.
New Zealand phylogeography: evolution on a small continent

New Zealand has long been a conundrum to biogeographers, possessing as it does geophysical and biotic features characteristic of both an island and a continent. This schism is reflected in provocative debate among dispersalist, vicariance biogeographic and panbiogeographic schools. A strong history in biogeography has spawned many hypotheses, which have begun to be addressed by a flood of molecular analyses. The time is now ripe to synthesize these findings on a background of geological and ecological knowledge. It has become increasingly apparent that most of the biota of New Zealand has links with other southern lands (particularly Australia) that are much more recent than the breakup of Gondwana. A compilation of molecular phylogenetic analyses of ca 100 plant and animal groups reveals that only 10% of these are even plausibly of archaic origin dating to the vicariant splitting of Zealandia from Gondwana. Effects of lineage extinction and lack of good calibrations in many cases strongly suggest that the actual proportion is even lower, in keeping with extensive Oligocene inundation of Zealandia. A wide compilation of papers covering phylogeographic structuring of terrestrial, freshwater and marine species shows some patterns emerging. These include: east–west splits across the Southern Alps, east–west splits across North Island, north–south splits across South Island, star phylogenies of southern mountain isolates, spread from northern, central and southern areas of high endemism, and recent recolonization (postvolcanic and anthropogenic). Excepting the last of these, most of these patterns seem to date to late Pliocene, coinciding with the rapid uplift of the Southern Alps. The diversity of New Zealand geological processes (sinking, uplift, tilting, sea level change, erosion, volcanism, glaciation) has produced numerous patterns, making generalizations difficult. Many species maintain pre‐Pleistocene lineages, with phylogeographic structuring more similar to the Mediterranean region than northern Europe. This structure reflects the fact that glaciation was far from ubiquitous, despite the topography. Intriguingly, then, origins of the flora and fauna are island‐like, whereas phylogeographic structure often reflects continental geological processes.
Granulocyte Macrophage Colony‐Stimulating Factor Improves Survival in Two Models of Gut‐Derived Sepsis by Improving Gut Barrier Function and Modulating Bacterial Clearance

ObjectiveThe effect of recombinant murine granulocyte macrophage colony-stimulating factor (rmGM-CSF) on survival and host defense was studied using two clinically relevant models of infection that included transfusion-induced immunosuppression. Summary Background DataGranulocyte macrophage colony-stimulating factor improves resistance in several models of infection, but its role in transfusion-induced immunosuppression and bacterial translocation (gut-derived sepsis) has not been defined. MethodsBalb/c mice were treated with 100 ng of rmGM-CSF or placebo for 6 days in a model of transfusion, burn, and gavage, or cecal ligation and puncture (CLP). Translocation was studied in the first model. ResultsSurvival after transfusion, burn, and gavage was 90% in rmGM-CSF-treated animals versus 35% in the control group (p < 0.001). After CLP, survival was 75% in the rmGM-CSF group versus 30% in the control group (p = 0.01). Less translocation and better killing of bacteria was observed in the tissues in animals treated with rmGM-CSF. ConclusionThe ability of rmGM-CSF to improve gut barrier function and enhance killing of translocated organisms after burn injury-induced gut origin sepsis was associated with improved outcome. Granulocyte macrophage colony-stimulating factor also improved survival after CLP.
Online Appendix, Codebook, Public Dataset, and Code, to Accompany Medical Liability Insurance Premia 1990-2015: Dataset, Literature Review, and Summary Information

This appendix offers a codebook for the MLM dataset available in “Medical Liability Insurance Premia 1990-2015: Dataset, Literature Review, and Summary Information,” plus detailed documentation on the procedures used to create the MLM dataset. We document features of the MLM and NAIC premium data with heat maps, comparing patterns in MLM premia to changes in tort reform laws and medical malpractice payout data from the National Practitioner Data Bank (NPDB). You can download this Appendix, together with the Codebook, statistical code, and the public version of the dataset (which includes MLM data from 1990-2002) from http://ssrn.com/abstract=2716911. To obtain the full dataset, with MLM data through 2015, you must first purchase a subscription to MLM. To do so, please contact Michael Matray, the editor of MLM, at editor@medicalliabilitymonitor.com. The current cost is $395 for a one-year subscription. MLM will confirm your subscription to us, and we will then provide the link to the full dataset to you.The overview document, Medical Liability Insurance Premia 1990-2015: Dataset, Literature Review, and Summary Information is available on SSRN at http://ssrn.com/abstract=2477120
Investigation of brain activation with body schema induced by TENS using NIRS

The body schema is a brain function to grasp own body location spatially. When a person uses tools or manipulates machines, the body schema is modified unconsciously, and he/she perceives these tools or machines as a part of his/her own body. In this study, brain activation adapting the strength of the body schema modification was investigated, and the possibility to interfere the body schema by electrical stimulus was confirmed. A tracing task (in which the participant traced characters using own hand with a stick) was designed, and the electrical stimulus was provided to the participant during the tracing task. And, cerebral blood flow was measured using near-infrared spectroscopy (NIRS) simultaneously and was analyzed. The brain activation under several conditions (the strength of the body schema modification and the strength of the electrical stimulus) was investigated using the paired t-test. The results showed that the inferior parietal lobule and the occipital lobe were significantly activated (t(8) = 1.860, p <; . 05) in case of the strongest body schema modification condition. Moreover the strongest electrical stimulus had a tendency that it activated the above brain areas significantly (t(8) = 1.860, p <; . 05). In consequence, it was found that the body schema modification could be induced by the electrical stimulus.
Finding Good Candidate Node-Encircling Pre-configuration Cycles in Survivable WDM Mesh Networks

A fault recovery system that is fast and reliable is essential in survivability design in wavelength-division-multiplexing (WDM) mesh networks. Pre-configuration cycle (p-cycle) benefits both the fast recovery time and the efficient resource utilization. Finding good candidate p-cycles is the first and very important step in p-cycle design. The node-encircling p-cycle can protect not only the on-cycle links and the straddling links but also the central node and the straddling flows. In this paper, we present a novel algorithm, called the Node-encircling p-cycles mining algorithm (NCMA), to efficiently find good candidate node-encircling p-cycles. The qualities of p-cycles generated by our algorithm are controlled by several input parameters. The algorithm is also suitable for finding some special link p-cycles which must contain some fixed nodes. Finally, the performance of the algorithm is gauged by running on some real world network topologies
0.25- $\mu \text{m}$  BiCMOS System-on-Chip for K-/Ka-Band Satellite Communication Transmit–Receive Active Phased Arrays

The first millimeter-wave system-on-chip for dual-band phased array applications is presented as a proof of concept for K-/Ka-band (20/30 GHz) satellite communication on-the-move applications. Each chip includes four transmit (Tx) and two receive (Rx) channels working at Ka- and K-band, respectively. The proposed architecture enables a half-duplex operating mode in two different bands. Its development was driven taking into account the integration into a realistic Tx/Rx shared aperture phased array architecture. Full amplitude and phase control are provided for each channel with high granularity (65 536 states). The measured results demonstrate the validity of the proposed chip architecture, even though the channel output power and the noise figure (NF) are not in full agreement with the simulations. In Tx mode, the channel provides 9.47 dB of gain with 4.19-dBm output power at 1-dB compression. In Rx mode, the channel gain is 21.6 dB with an NF of 5 dB. In a scenario with 5.265° phase steps and 8-dB amplitude tapering capability, the amplitude and phase root-mean-square (RMS) errors within the Tx bandwidth (29.5–30.8 GHz) are equal to 0.52 dB and 3.74°, respectively. The amplitude and phase RMS errors in the Rx bandwidth (19.7–21 GHz) are equal to 2.05 dB and 12.11°, respectively. The chip consumes 340 mW in Tx and 242 mW in Rx mode and occupies $3.3 \times 3.5$ mm2.
The Effect of Trabeculectomy on Astigmatism

Purpose:To investigate the change in corneal astigmatism after trabeculectomy. Patients and Methods:Between January and April 2012, patients who underwent a primary trabeculectomy were enrolled in this prospective study. We measured the visual acuity, automated keratorefractometry, and the intraocular pressure preoperatively and postoperatively at 1, 3, and 6 months. Changes in astigmatism were quantified using the vector analysis described by Cravy. A Friedman test and a linear model for longitudinal measures were used to compare changes in the refraction and the intraocular pressure. A binomial test was used to compare the proportion of eyes with a shift in astigmatism with or against-the-rule. Results:A total of 47 eyes (47/48 patients) were included for analysis. The mean (±SD) intraocular pressure decreased from 17.5±5.4 mmHg preoperatively to 9.8±4.0 mmHg after 6 months (P<0.001). At this time-point, 32/47 eyes showed a shift in astigmatism with-the-rule (P=0.02), with a median difference in cylinder of +0.50 D (range, 0 to 4 D) (P=0.004). The mean (±SD) axis of the positive cylinder changed from 169±148 to 135±146 degrees after 6 months (P=0.12) and the mean (±SD) spherical equivalent changed from −0.47±2.27 to −0.07±1.93 D (P=0.15). The mean (±SD) logMAR was 0.17±0.22 preoperatively and 0.14±0.14 after 6 months (P=0.9). Conclusions:Trabeculectomy induced a small but statistically significant shift in astigmatism with-the-rule after 6 months. The spherical equivalent did not change compared with the preoperative value. Most often, glasses will not need to be changed after trabeculectomy.
All coronary artery bypass graft surgery patients will benefit from angiotensin-converting enzyme inhibitors.

Angiotensin-converting enzyme (ACE) inhibitors have been shown to prolong survival and to decrease infarct size in patients after acute coronary syndromes.1–3 Evidence now exists that ACE inhibitors are effective in decreasing myocardial injury during coronary artery bypass graft surgery (CABG) and can reduce the incidence of ischemic events in the years after surgery.4,5 It has been suggested that all CABG patients be started on ACE inhibitors, in addition to a statin, aspirin, and β-blocker, as part of a cardioprotective strategy to reduce recurrent ischemic events in these patients.6 In this issue of Circulation , Rouleau and coworkers7 present data from the Ischemia Management with Accupril post-bypass Graft via Inhibition of the coNverting Enzyme (IMAGINE) trial that question this benefit for all CABG patients. They conclude that in low-risk CABG patients, routine early initiation of ACE inhibitor therapy does not appear to improve clinical outcomes up to 3 years after surgery and may actually increase adverse events in the early postoperative period. They feel that ACE inhibitor therapy should be individualized and reassessed over time. Are the results of this study applicable to the vast majority of CABG patients? Can we accurately identify patients who are at low risk of developing future cardiovascular events at the time of CABG surgery? What is the best method of initiating ACE inhibitor therapy in the post-CABG patient, and were these guidelines followed by the IMAGINE investigators? Here, I will attempt to answer these questions as we try to determine the role of ACE inhibitor therapy in the CABG patient. Article p 24 ACE inhibitors have the potential to benefit CABG patients not only by their antihypertensive effects but also because of their vasculoprotective and antiatherogenic properties. They minimize thrombosis by reducing platelet aggregation and decreasing plasminogen activator-1 and tissue plasminogen …
Developmental status of preschool children receiving cART: a descriptive cohort study.

BACKGROUND HIV is known to cause neurodevelopmental problems in infants and young children. The impact of HIV on the development of preschool-age children has been less well described. METHOD The study was conducted at an urban paediatric HIV clinic in Johannesburg, South Africa. A sample of convenience was used. Sixty-eight medically stable children between the ages of 3 and 5 years were assessed with the Griffiths Scales of Mental Development. Children were excluded from the study if they had severe HIV encephalopathy, which made it impossible for them to participate in the items on the Griffiths Scales of Mental Development. RESULTS The children had started combination antiretroviral treatment (cART) at a mean age of 8.1 months. The majority of the children were virologically suppressed and did not present with wasting or stunting. Severe overall developmental delay (z-scores < -2SD) was detected in 55.88% of children. Developmental facets related to speech, cognition and perception were the most severely affected. Personal-social development was the least affected with only 13.4% of the children demonstrating severe delay. CONCLUSION Despite having early access to cART, children infected with HIV are still at risk for severe developmental delay across a number of facets. Very early initiation of cART may help alleviate this problem. All preschool children infected with HIV should have routine developmental screening.
Modelling the Gold Price in Turkish Free Market: Static Approach (Determinanty cen złota na wolnym rynku tureckim: podejście statystyczne)

In this paper, we analyse the determinants of gold prices in the Turkish free market using classic linear regression techniques. We modeled the gold price movement using two static models, a simple linear and a polynomial of degree three. We compared two models and concluded that third degree polynomial regression model fitted our data better and has greater explanatory power than simple linear model. Furthermore the most significant determinants of the gold price in Turkey are found to be gold mine production, US dollar exchange rate against Turkish lira and the consumer price index (TUFE).