Miracle-dz/UniFAR-FTUs huggingface dataset:
RankMerging: Apprentissage supervisé de classements pour la prédiction de liens dans les grands réseaux sociaux

Trouver les liens manquants dans un grand reseau social est une tâche difficile, car ces reseaux sont peu denses, et les liens peuvent correspondre a des environnements structurels varies. Dans cet article, nous decrivons RankMerging, une methode d'apprentissage supervise simple pour combiner l'information obtenue par differentes methodes de classement. Afin d'illustrer son interet, nous l'appliquons a un reseau d'utilisateurs de telephones portables, pour montrer comment un operateur peut detecter des liens entre les clients de ses concurrents. Nous montrons que RankMerging surpasse les methodes a disposition pour predire un nombre variable de liens dans un grand graphe epars.
Postdischarge Environment Following Heart Failure Hospitalization: Expanding the View of Hospital Readmission

Readmission after hospitalization for heart failure (HF) has received increasing attention due to the significant burden it places on patients and payers. [1][1]–[2][2] Among Medicare beneficiaries, readmission within 30 days following heart failure hospitalization approaches 25%. [2][2] Even after
A korarchaeal genome reveals insights into the evolution of the Archaea

The candidate division Korarchaeota comprises a group of uncultivated microorganisms that, by their small subunit rRNA phylogeny, may have diverged early from the major archaeal phyla Crenarchaeota and Euryarchaeota. Here, we report the initial characterization of a member of the Korarchaeota with the proposed name, “Candidatus Korarchaeum cryptofilum,” which exhibits an ultrathin filamentous morphology. To investigate possible ancestral relationships between deep-branching Korarchaeota and other phyla, we used whole-genome shotgun sequencing to construct a complete composite korarchaeal genome from enriched cells. The genome was assembled into a single contig 1.59 Mb in length with a G + C content of 49%. Of the 1,617 predicted protein-coding genes, 1,382 (85%) could be assigned to a revised set of archaeal Clusters of Orthologous Groups (COGs). The predicted gene functions suggest that the organism relies on a simple mode of peptide fermentation for carbon and energy and lacks the ability to synthesize de novo purines, CoA, and several other cofactors. Phylogenetic analyses based on conserved single genes and concatenated protein sequences positioned the korarchaeote as a deep archaeal lineage with an apparent affinity to the Crenarchaeota. However, the predicted gene content revealed that several conserved cellular systems, such as cell division, DNA replication, and tRNA maturation, resemble the counterparts in the Euryarchaeota. In light of the known composition of archaeal genomes, the Korarchaeota might have retained a set of cellular features that represents the ancestral archaeal form.
The child in sight, in mind and right in the centre: Child-centred, family inclusive reunification

This paper describes a reunification program that places particular emphasis on the centrality of children in the process. There is recognition of the ways in which children get 'lost' in a process where the development of adult focused goals is negotiated in a climate of high emotion. Adult wishes, needs and rights can often be in a position of tension with those of children. It highlights the strategies and tools that are used by practitioners to redress power imbalance, to avoid adult goals being privileged over the needs and wellbeing of children, and enables the voices and views of children to guide practice and decision-making. The challenge for practitioners is to hold the perspective of the children firmly in mind, with their safety as the primary goal of intervention. The principles and practices that keep the child visible and active in the process of reunification are highlighted.
Exogenous levodopa increases the neuro retinal dopamine of guinea pig myopic eyes in vitro.

PURPOSE In our previous work, it has been shown that intraperitoneal injection of L-DOPA can inhibit the development of occlusion myopia in guinea pigs, and increase levels of retinal dopamine. The aim of this study was to investigate whether exogenous L-DOPA can be converted into dopamine in cultured retina of guinea pig eyes subjected to visual deprivation, and to evaluate whether müller cells are involved in the processing of retinal dopamine induced by L-DOPA. METHODS Fifty-eight guinea pigs were randomly divided into 2 groups at the age of 4 weeks: normal control and visual deprivation. Form deprivation was induced with translucent eye shields over the right eye, and lasted for ten days. Corneal curvature, refraction and axial length were measured in all animals. In vitro, neuro-retina and müller cell were cultured, and L-DOPA was added to the culture medium at three concentrations: 1цM, 10цM and 100цM. Subsequently, dopamine content was evaluated by high-performance liquid chromatography, and apoptotic cells were identified by TUNEL staining. RESULTS Ten days of occlusion caused the affected eyes to elongate and become myopic in guinea pigs. Compared with the deprivation group, 10цM L-DOPA treament significantly raised dopamine content in cultured retina and müller cells (P<0.05). However, 1цM and 100цM L-DOPA treatment caused no increase in dopamine levels (P>0.05). Apoptotic nuclei were detected in the ganglion cell layer (92.5%±8.3%) and inner nuclear layer (46.8%±9.1%) of cultured retina treated with 100 цM L-DOPA. Moreover, 100 цM L-DOPA also caused apoptosis of retinal müller cells, at a mean rate of 59.4 ±11.3%. CONCLUSION Our results suggest that exogenous L-DOPA can cause an increase in retinal dopamine in form-deprived guinea pig eyes in vitro, and that müller cells are involved in the increase in retinal dopamine.
Evaluating Population Receptive Field Estimation Frameworks in Terms of Robustness and Reproducibility

Within vision research retinotopic mapping and the more general receptive field estimation approach constitute not only an active field of research in itself but also underlie a plethora of interesting applications. This necessitates not only good estimation of population receptive fields (pRFs) but also that these receptive fields are consistent across time rather than dynamically changing. It is therefore of interest to maximize the accuracy with which population receptive fields can be estimated in a functional magnetic resonance imaging (fMRI) setting. This, in turn, requires an adequate estimation framework providing the data for population receptive field mapping. More specifically, adequate decisions with regard to stimulus choice and mode of presentation need to be made. Additionally, it needs to be evaluated whether the stimulation protocol should entail mean luminance periods and whether it is advantageous to average the blood oxygenation level dependent (BOLD) signal across stimulus cycles or not. By systematically studying the effects of these decisions on pRF estimates in an empirical as well as simulation setting we come to the conclusion that a bar stimulus presented at random positions and interspersed with mean luminance periods is generally most favorable. Finally, using this optimal estimation framework we furthermore tested the assumption of temporal consistency of population receptive fields. We show that the estimation of pRFs from two temporally separated sessions leads to highly similar pRF parameters.
PMD of installed fiber - an overview

Polarization mode dispersion (PMD) of installed fiber are studied. Data from a standard high-fiber count, buried, ducted cable of recent vintage (c. 1999) NZ-DSF fiber (True Wave Reduced Slope) are presented. This includes long-term measurements from interferometric and wavelength-scanned techniques as well as a new in-situ technique. Some of the challenges for PMD are also discussed.
Evolving practice patterns in treatment of major retinal diseases in Singapore.

Dear Editor, Neovascular (“wet”) age-related macular degeneration (AMD), diabetic macular edema (DME) and retinal vein occlusion (RVO) are amongst the most common causes of blindness.1-3 Traditionally, these conditions were treated with thermal laser photocoagulation, however, the advent of anti-vascular endothelial growth factor (VEGF) has revolutionised the treatment of these diseases.1,4,5 These anti-VEGF agents (ranibizumab and bevacizumab) aim to stop retinal angiogenesis and reduce macular oedema. Numerous trials have evaluated the effi cacy of these treatments in western populations, however, there are no clear guidelines for antiVEGF use in Asian countries where the pattern of retinal disease is different. This study surveyed the current practice patterns of ophthalmologists in Singapore with regards to the use of anti-VEGF and established therapies for the management of 3 major retinal disease: AMD, DME and central retinal vein occlusion (CRVO).
Bulbar Paralysis and Facial Paralysis due to Metastatic Hepatocellular Carcinoma

AbstractSkull-base metastasis (SBM) from hepatocellular carcinoma (HCC) is extremely rare, and multiple cranial nerve paralysis due to SBM from HCC is also rare. We report a case of bulbar and facial paralysis due to SBM from HCC.A 46-year-old Chinese man presented with a hepatic right lobe lesion that was detected during a routine physical examination. After several failed attempts to treat the primary tumor and bone metastases, neurological examination revealed left VII, IX, X, and XI cranial nerve paralysis. Computed tomography of the skull base subsequently revealed a large mass that had destroyed the left occipital and temporal bones and invaded the adjacent structure. After radiotherapy (27 Gy, 9 fractions), the patient experienced relief from his pain, and the cranial nerve dysfunction regressed. However, the patient ultimately died, due to the tumor's progression.Radiotherapy is usually the best option to relieve pain and achieve regression of cranial nerve dysfunction in cases of SBM from HCC, although early treatment is needed to achieve optimal outcomes. The present case helps expand our understanding regarding this rare metastatic pathway and indicates that improved awareness of SBM in clinical practice can help facilitate timely and appropriate treatment.
2-Amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} Acetamide (OSU-03012), a Celecoxib Derivative, Directly Targets p21-Activated Kinase

p21-Activated kinases (PAKs) are regulators of cell motility and proliferation. PAK activity is regulated in part by phosphoinositide-dependent kinase 1 (PDK1). We hypothesized that reduced PAK activity was involved in the effects of 2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a previously characterized PDK1 inhibitor derived from celecoxib. In three human thyroid cancer cell lines, OSU-03012 inhibited cell proliferation with reduced AKT phosphorylation by PDK1. OSU-03012 unexpectedly inhibited PAK phosphorylation at lower concentrations than PDK1-dependent AKT phosphorylation in two of the three lines. In cell-free kinase assays, OSU-03012 was shown to inhibit PAK activity and compete with ATP binding. In addition, computer modeling predicted a docking site for OSU-03012 in the ATP binding motif of PAK1. Finally, overexpression of constitutively activated PAK1 partially rescued the ability of motile NPA thyroid cancer cells to migrate during OSU-03012 treatment, suggesting that inhibition of PAK may be involved in the cellular effects of OSU-03012 in these cells. In summary, OSU-03012 is a direct inhibitor of PAK, and inhibition of PAK, either directly or indirectly, may be involved in its biological effects in vitro.
Optimizing Position Updates for kNN - Is It Worth It?

Keeping a mobile device always up-do-date about the k nearest neighbor (kNN) points of interest (PoIs) is a common challenge of location based services. The challenge lies in the fact that the set of PoIs available at the device needs to always remain correct and fresh while the mobile user may be constantly moving about. To this end, in a very simple approach, the position of the device could be continuously updated with the server- side, whenever it changes. Since this simple approach creates a potential communication overhead, several optimizations have been proposed in literature, all of which significantly reduce the amount of messages sent over the air. However, location based service (LBS) developers have been left clueless until today about whether deploying those complex strategies into their systems actually improves battery life sig- nificantly - which is arguably the most important aspect for the end user. As a way to remedy, this paper critically examines optimized kNN tracking, based on real-life data sets and in the light of actual battery drainage.
A Fast Iterative Algorithm for Improved Unsupervised Feature Selection

Dimensionality reduction is often a crucial step for the successfulapplication of machine learning and data mining methods. One way toachieve said reduction is feature selection. Due to the impossibilityof labelling many data sets, unsupervised approaches arefrequently the only option. The column subset selection problemtranslates naturally to this purpose, and has received considerableattention over the last few years, as it provides simple linear modelsfor data reconstruction. Existing methods, however, often achieveapproximation errors that are far from the optimum. In this paper wepresent a novel algorithm for column subset selection thatconsistently outperforms state-of-the-art methods in approximationerror. We present a series of key derivations that allow anefficient implementation, making it comparable in speed and in somecases faster than other algorithms. We also prove results that make itpossible to deal with huge matrices, which has strong implications for otheralgorithms of this type in the big data field. We validate our claimsthrough experiments on a wide variety of well-known data sets.
Efficient Motion Compensation Architecture with Rate-Distortion Optimization for H.264/AVC

In this paper, a novel motion compensation architecture is proposed to support the Rate-Distortion Optimization(RDO) in H.264/AVC. First, the scope of the motion compensation in this work is defined not only including the half and quarter pixel motion compensation but also the deblocking filter and rate-distortion optimazation. Then, base on the new concept of motion compensation an efficient architecture for H.264/AVC codec is constructed. Proposed architecture could select the best mode for INTRA macroblocks using the lagrange function by calculating the distortion and the generated bits. It could also calculate the lagrange function for INTER macroblocks by receiving the motion vector information and the interpolation data from the ME(Motion Estimation) module to construct a complete rate distortion optimization architecture. Pipelined processing structure is designed for sub-block mode selection to achieve real-time processing for up to HDTV resolution inputs. Implementation result shows that proposed architecture could be realized with only 42,280 gates and 48,320 bits SRAM.
Role of Alkyl Hydroperoxide Reductase (AhpC) in the Biofilm Formation of Campylobacter jejuni

Biofilm formation of Campylobacter jejuni, a major cause of human gastroenteritis, contributes to the survival of this pathogenic bacterium in different environmental niches; however, molecular mechanisms for its biofilm formation have not been fully understood yet. In this study, the role of oxidative stress resistance in biofilm formation was investigated using mutants defective in catalase (KatA), superoxide dismutase (SodB), and alkyl hydroperoxide reductase (AhpC). Biofilm formation was substantially increased in an ahpC mutant compared to the wild type, and katA and sodB mutants. In contrast to the augmented biofilm formation of the ahpC mutant, a strain overexpressing ahpC exhibited reduced biofilm formation. A perR mutant and a CosR-overexpression strain, both of which upregulate ahpC, also displayed decreased biofilms. However, the introduction of the ahpC mutation to the perR mutant and the CosR-overexpression strain substantially enhanced biofilm formation. The ahpC mutant accumulated more total reactive oxygen species and lipid hydroperoxides than the wild type, and the treatment of the ahpC mutant with antioxidants reduced biofilm formation to the wild-type level. Confocal microscopy analysis showed more microcolonies were developed in the ahpC mutant than the wild type. These results successfully demonstrate that AhpC plays an important role in the biofilm formation of C. jejuni.
Observed trends in extreme precipitation events in China during 1961–2001 and the associated changes in large‐scale circulation

The observed trends in extreme precipitation events, and those in annual and seasonal mean precipitation in China during 1961–2001 are analyzed. The results show that the annual mean precipitation increases significantly in southwest, northwest, and east China, and decreases significantly in central, north and northeast China. The increasing trends in east China occurred mainly in summer, while the decreasing trends in central, north, and northeast China occurred in both spring and autumn. The increasing trends in most of northwest China occurred in all seasons. Patterns of the trends in extreme daily precipitation events are similar to those in the annual and seasonal mean precipitation except in the northwest China where most areas show increasing trends in extreme events only in summer. The extreme precipitation events in the Yangtze River basin increased dramatically by 10%–20% every 10 years in summer, consistent with the increasing trends in summer mean precipitation in the region. The circulation over East Asia shows a weakening trend in the summer monsoon over central‐east China.
340 GHz Integrated Receiver in 250 nm InP DHBT Technology

A 340 GHz integrated receiver based on a 250 nm InP DHBT technology is presented in this paper. It consists of a 2 × 2 differential patch array antenna, a sub-harmonically pumped Gilbert mixer and an IF buffer amplifier. Performance of the integrated receiver is evaluated by setting up a RF link in the frequency band of 302-338 GHz. At 338 GHz RF and 170 GHz LO, the peak conversion gain of 11.8 and 14.0 dB is achieved with and without antenna, respectively. A double-sideband noise figure of 17 dB at room temperature is obtained from direct noise figure measurement .
Gene transfer of dominant-negative RhoA increases outflow facility in perfused human anterior segment cultures.

PURPOSE To investigate the regulation of expression and the role of the RhoA gene in the human trabecular meshwork (TM). To attempt to modulate outflow facility by gene transfer of the RhoA gene's dominant-negative mutant protein. METHODS Total RNA extracted from cultured human trabecular meshwork (HTM) cells treated with outflow facility drugs were analyzed by northern blot hybridization using an amplified human RhoA cDNA from plasmid pZip-RhoA wild type (wt) [1]. A dominant-negative form of RhoA (single amino acid substitution of Thr19 to Asn) was placed under the control of the CMV promoter and inserted into a replication-deficient adenoviral vector by overlapping recombination (AdhRhoA2). AdhRhoA2 was infected into perfused anterior segment cultures from post-mortem human donors and HTM and Schlemm's canal cells in culture. Changes in outflow facility (flow/pressure) were calculated as percent changes from baseline values (C0), pooled into treated and control groups and expressed as the mean plus minus standard error. HTM and Schlemm's Canal (SC) cells were fluorescently double-labeled for the RhoA protein and actin, paxillin, or ZO-1. RESULTS Transcription of RhoA in HTM cells was not considerably affected by treatment of the cells with cytoskeletal/outflow facility drugs. At 66 h post-injection, anterior segments treated with AdhRhoA2 (n=9) exhibited an increase in outflow facility of 32.5 +/- 7.7% while that of the vehicle-injected controls (n=6) was 5.1 +/- 4.0% (p=0.02). HTM cells treated with AdhRhoA2 showed a marked change in morphology with a reduction in actin stress fibers and of the focal adhesion-containing protein, paxillin. Confluent monolayers of SC cells infected with AdhRhoA2 were devoid of peripheral ZO-1 staining indicating a loss of intercellular junctions. CONCLUSIONS In the HTM cells, cytoskeletal/outflow facility drugs do not seem to affect the levels of RhoA mRNA, possibly suggesting the importance of mRNA availability to allow rapid turnover of its function. Gene transfer of inactive RhoA to the intact human TM results in an increase in outflow facility. This increase appears to be correlated with a loosening of the cell-substrate and cell-cell attachments in the cells of the outflow pathway. Adenoviral vectors carrying the dominant negative form of RhoA could potentially be utilized as a gene therapy to modulate outflow facility.
Effects of N-Glycosylation and Inositol on the ER Stress Response in Yeast Saccharomyces cerevisiae

IRE1 and HAC1 are essential for the unfolded protein response in the endoplasmic reticulum (ER). IRE1- and HAC1-disruptants require high concentrations of inositol for its normal growth. The ALG6, ALG8, and ALG10 genes encode the glucosyltransferases necessary for the completion of the synthesis of the lipid-linked oligosaccharide used for the asparagine-linked glycosylation of proteins in that order. Here we show that, given a combination of the hac1 defect with a disruption of ALG6, ALG8, and ALG10, no strains grow on inositol-free medium. However, the growth defect of the hac1-alg10 double disrupted was partially, but significantly, suppressed by the addition of inositol to the medium. These results indicate that inositol, according to the numbers of glucose residues in the oligosaccharide, plays an important role in the stress response and quality control of glycoproteins in the ER.
Comparison of Coaches' and Athletes' Causal Attributions after Success and Failure: A Survey of the Islamic Azad Universities of District 10

This study aimed at comparison of coaches' and athletes' causal attributions after success and failure. The population of the study consisted of all the coaches and athletes who attended the sports teams of the Islamic Azad universities of district 10. From among the population, 50 coaches (25 males and 25 females) and 50 athletes (25 males and 25 females) were selected randomly. A modified version of Attribution Style questionnaire (Khodaverdi, 2005) was used to collect the data. Based on the nature and objectives of the study, the research took on the design of a descriptive survey. Both descriptive and inferential statistics were used to analyze the data. Qualitative data was described using percentage. Besides, inferential statistics including Chi-square test, Pearson correlation coefficient formula and Cramer's correlation coefficient formula were run to analyze and interpret the data. According to the coaches' responses to the causes of four success-induced situations, the content analysis of their attributions revealed the major sources of success to be God' will (27%), effort (15.5%), interest and motivation (14.5%). However, their most important attributions for failure were lack of effort (23.5), inability (15%) and lack of interaction with others (11%). On the other hand, the athletes' most fundamental attributions for success were God's will (30%), effort (29%), interest and motivation (12%). Their most fundamental attributions for failure included lack of effort (28%), mischance (11.5%) and lack of interaction with others (11%).
THP based on cholesky factorization with unitary transformation for multiuser MIMO

This paper proposes two types of Tomlinson-Harashima precoding (THP) based on Cholesky factorization for multiuser MIMO systems where the receiver has at least two antennas. In the system with the THP, a linear filter is introduced for the receiver. It is shown by computer simulation that the BER performance of the THP is much superior to that of the conventional THP.