Miracle-dz/UniFAR-FTUs huggingface dataset:
Bioavailable Flavonoids: Cytochrome P450-Mediated Metabolism of Methoxyflavones

Methoxylated flavones were recently shown to be promising cancer chemopreventive agents. Their high metabolic stability compared with the hydroxylated analogs was shown in our laboratory using the human hepatic S9 fraction with cofactors for glucuronidation, sulfation, and oxidation. In the present study, the resistance of methoxylated flavones toward oxidative metabolism was investigated with human liver microsomes and recombinant cytochrome P450 (P450) isoforms. Among 15 methoxylated flavones investigated, the two partially methylated compounds, tectochrysin and kaempferide, were among the most susceptible to microsomal oxidation (Clint 283 and 82 ml/min/kg). Of the fully methylated compounds, 5,7-dimethoxyflavone and 5-methoxyflavone were the most stable (Clint 13 and 18 ml/min/kg, respectively), whereas 4′-methoxyflavone, 3′-methoxyflavone, 5,4′-dimethoxyflavone, and 7,3′-dimethoxyflavone were the least stable (Clint 161, 140, 119, and 92 ml/min/kg, respectively), emphasizing the importance of the positions of the methoxy substituents in the flavone ring system. Among the five P450 isoforms tested, CYP1A1 showed the highest rate of metabolism of fully methylated compounds, followed by CYP1A2 and CYP3A4. CYP2C9 and CYP2D6 gave minimal disappearance of the parent compound. Finally, in incubations with hepatic S9 fraction with cofactors for oxidation and both conjugation reactions, partially methylated flavones, as expected, were much less metabolically stable than fully methylated flavones, confirming that oxidative demethylation is the rate-limiting metabolic reaction for fully methylated flavones only. In summary, the rate of oxidative metabolism of methoxylated flavones, mainly involving CYP1A1 and CYP1A2, varied widely, even between compounds with very similar structures.
Dynamic Simulation of Electro-Hydrodynamically Interacting and Sedimenting Particles

Particle-particle interactions in sedimenting systems have been investigated in the present study considering the many-body hydrodynamic and electrodynamic interactions. These interactions primarily occur in two modes: near-field and far-field interactions. The hydrodynamic interactions are modeled employing the Stokesian Dynamics while the electrodynamic interactions are accounted using the grand Capacitance matrix formulation capable of tackling externally applied arbitrary electric field effects. It is seen that the presence of an external electric field and asymmetry in particle positioning greatly modifies the dynamics of the rigid dielectric spherical particles when compared with the sedimenting system without the electric field effects. This is attributed to the induced dipole moment interactions among the particles. A consequence of the alterations in the particle arrangements also changes the net drag force experienced by these sedimenting particles, which is also reported in the present study. Furthermore, we have evaluated the induced background velocity field of the continuous medium due to sedimentation of the particles. A net velocity is observed in the continuous medium due to the sedimentation-induced particle rotation, which is found to vary in presence of an external electric field.
An allosteric model of the molecular interactions of excitation- contraction coupling in skeletal muscle

A contact interaction is proposed to exist between the voltage sensor of the transverse tubular membrane of skeletal muscle and the calcium release channel of the sarcoplasmic reticulum. This interaction is given a quantitative formulation inspired in the Monod, Wyman, and Changeux model of allosteric transitions in hemoglobin (Monod, J., J. Wyman, and J.-P. Changeux. 1965. Journal of Molecular Biology. 12:88- 118), and analogous to one proposed by Marks and Jones for voltage- dependent Ca channels (Marks, T. N., and S. W. Jones. 1992. Journal of General Physiology. 99:367-390). The allosteric protein is the calcium release channel, a homotetramer, with two accessible states, closed and open. The kinetics and equilibrium of this transition are modulated by voltage sensors (dihydropyridine receptors) pictured as four units per release channel, each undergoing independent voltage-driven transitions between two states (resting and activating). For each voltage sensor that moves to the activating state, the tendency of the channel to open increases by an equal (large) factor. The equilibrium and kinetic equations of the model are solved and shown to reproduce well a number of experimentally measured relationships including: charge movement (Q) vs. voltage, open probability of the release channel (Po) vs. voltage, the transfer function relationship Po vs. Q, and the kinetics of charge movement, release activation, and deactivation. The main consequence of the assumption of allosteric coupling is that primary effects on the release channel are transmitted backward to the voltage sensor and give secondary effects. Thus, the model reproduces well the effects of perchlorate, described in the two previous articles, under the assumption that the primary effect is to increase the intrinsic tendency of the release channel to open, with no direct effects on the voltage sensor. This modification of the open-closed equilibrium of the release channel causes a shift in the equilibrium dependency of charge movement with voltage. The paradoxical slowing of charge movement by perchlorate also results from reciprocal effects of the channel on the allosterically coupled voltage sensors. The observations of the previous articles plus the simulations in this article constitute functional evidence of allosteric transmission.
Exact and asymptotic synchronization of a new weakly coupled maps system

The paper deals with the synchronization of a new statistically highly performant function firstly introduced by Lozi. The synchronization is reached via observers which reconstruct all the states of the original system, using only a partial information of it. The map has been rewritten as a piece-wise affine one, which allows to design two types of observers: an exact (dead-beat) observer, and an asymptotic observer. Both observers have been analysed and compared; the dead-beat observer guarantees an exact convergence; however, synchronization can not be preserved in an autonomous regime (if the observer is switched off), because the map is highly chaotic, and the trajectories diverge due to the finite computer precision. The asymptotic observer is more robust in case of noise, but the convergence is slower, and the error converges to zero only asymptotically. In the latter case, several observers have to run in parallel, and the criteria to select the converging one are derived
5Gbits/sec, 300mV Precharge, 256b, Low Power Rhythmic SRAM

Effective design of cache SRAM has always been the challenging task in embedded systems dedicated to image processing applications such as vector quantizer (VQ). The low power high speed SRAM array is the need of VQ. The mathematical model and simulation results for low power, high speed, fault tolerant codebook SRAM is presented in this paper. The cell, precharge, transmission logic, sense amplifier, redundant bits and IOs are modeled and spice simulated. Since the codebook has rhythmic nature, the successive multiple read cycles are important than write. The implementation is done at 0. 25μm technology. The results show that the least precharge is at 300mV. The array operates minimum at 600mV. The dissipation of 256 b array is 1.8mW at read speed of 5Gbits/sec at precharge of 1.25V and supply of 2.5V.
Mobility Modeling in Mobile Ad Hoc Networks with Environment-Aware

Simulation is the most important and widely used method in the research of Mobile Ad hoc NETworks (MANET). The topology of MANET and the mobility of mobile nodes are the key factors that have an impact on the performance of protocols. However, most of the existing works are based on random movement and the fact that the network topology is highly related to the environment of MANET is overlooked. In this paper, we propose a novel Environment-Aware Mobility (EAM) model which models a more realistic movement of mobile nodes. Environment objects such as Route and Hotspot are introduced to represent the environment components which are rendered by Scalable Vector Graphics (SVG). It is considered to be a complex model with a combination of existing conventional mobility models and network environments. This paper shows that various MANET environments can be modeled based on this work. A sample environment is also simulated and the results show that the intrinsic characteristics and properties of the environments have a significant influence on the performance of MANET protocols.
A reference architecture template for software-intensive embedded systems

The paper presents a document template for reference architectures for the domain of software-intensive embedded systems. The template addresses the somewhat conflicting needs when documenting a reference architecture of readability, overview, details, evolution and different background of the stakeholders. The first novel idea is the template prescribes two separate documents describing a reference architecture beside the product architecture documentation. The information in the two documents concern different stakeholders and evolve at different paces. The other novelty in describing reference architectures is to introduce a perspective of time, in the form of horizons, rather than focusing on a snapshot a release date. In addition, a case is presented giving an example of how a reference architecture was documented according to the template, how stakeholder needs were captured, and how the different types of information was identified or recovered from existing product architectures.
Phoneme Detection in Popular Music

30 second-snippets from 37 songs have been automatically extracted. All phonemes from this pieces have been manually labeled. The considered genre was popular music. 21 songs have been performed by male singers. 16 songs have been performed by female singers. Altogether 2244 phonemes have been manually labeled and can be used by the system. Only 15 voiced phonemes have been distinguished, because they are significantly separable for lyrics synchronization. Phoneme Detection in Popular Music
Securing Smartphones: A µTCB Approach

As mobile phones have evolved into smartphones, with complex operating systems running third-party software, they have become increasingly vulnerable to malicious applications (malware). The authors introduce a new design for mitigating malware attacks against smartphone users based on a small trusted computing base module, denoted μTCB. The μTCB manages sensitive data and sensors and provides core services to applications, independently of the operating system. The user invokes μTCB by pressing a simple secure attention key that validates physical possession of the device and authorizes a sensitive action. This approach protects private information even if the device is infected with malware. This article presents a proof-of-concept implementation of μTCB based on ARM's TrustZone, a secure execution environment increasingly found in smartphones. It also includes an evaluation of the implementation using simulations.
Evaluation of Bus-Exclusive Lanes

This paper presents a multimode dynamic traffic assignment (DTA) model for the impact analysis of the bus exclusive lane. First, a multimode point-queue model is proposed to reflect the interactions of cars and buses under two scenarios: networks with and without bus exclusive lanes. To capture the travel behaviors of mode choices, departure time choices, and path choices, an integrated variational inequality (VI) formulation is proposed. Then, a heuristic algorithm is developed to solve the VI problem. Finally, based on the proposed measures of effectiveness (MOEs) of travel cost, bus passengers, and queue length, the comparison analyses in virtual networks with and without bus exclusive lanes are presented by numerical examples.
Generalized Halton sequences in 2008: A comparative study

Halton sequences have always been quite popular with practitioners, in part because of their intuitive definition and ease of implementation. However, in their original form, these sequences have also been known for their inadequacy to integrate functions in moderate to large dimensions, in which case (t,s)-sequences such as the Sobol' sequence are usually preferred. To overcome this problem, one possible approach is to include permutations in the definition of Halton sequences—thereby obtaining generalized Halton sequences—an idea that goes back to almost thirty years ago, and that has been studied by many researchers in the last few years. In parallel to these efforts, an important improvement in the upper bounds for the discrepancy of Halton sequences has been made by Atanassov in 2004. Together, these two lines of research have revived the interest in Halton sequences. In this article, we review different generalized Halton sequences that have been proposed recently, and compare them by means of numerical experiments. We also propose a new generalized Halton sequence which, we believe, offers a practical advantage over the surveyed constructions, and that should be of interest to practitioners.
Robust ground plane detection from 3D point clouds

Ground provides useful and basic information such as traversal regions and location of 3D objects. The given point cloud may contain a point not only from ground, but also from other objects such as walls and people. Those points from other objects can disturb to find and identify a ground plane. In this paper, we propose robust and fast ground plane detection with an asymmetric kernel and RANSAC. We derive a probabilistic model of a 3D point based on an observation that a point from other objects is always above the ground. The asymmetric kernel is its approximation for fast computation, which is incorporated with RANSAC as a score function. We demonstrate effectiveness of our proposed method as quantitative experiments with our on-road 3D LiDAR dataset. The experimental result presents that our method was sufficiently accurate with slightly more computation. Finally, we also show our ground detection's application to augmented perception and visualization for drivers and remote operators.
GPU-based Arnoldi factorisation for accelerating finite element eigenanalysis

We present a GPU-accelerated implementation of the k-step Arnoldi factorisation [1] that forms the basis of a number of iterative eigenvalue system solvers. These solvers are important for the finite element analysis of the cutoff and dispersion characteristics of waveguide structures as well as cavity resonances [2] and since they contribute significantly to the runtime in computing a solution, their acceleration is of interest. The initial GPU-based implementation makes use of accelerated BLAS [3] routines for the CUDA API from NVIDIA (cublas) [4]. This allows us to utilise the computational power of the GPU at a functional level as a proof of concept with minimal coding effort. The implementation is then refined to make use of enhancements to the matrix-vector multiplication routines proposed by Fujimoto in [5] further improving performance.
Ruling out the MSSM at the low tan β fixed point

We analyse the mass spectrum of the Constrained Minimal Supersymmetric Standard Model at the low tanβ fixed point. We find that the model only satisfies experimental and dark matter bounds in regions where the vacuum is meta-stable – i.e. where it violates ‘unbounded from below’ (UFB) bounds. Adding a small amount of R-parity violation solves these problems but the absolute upper bound on the lowest higgs mass mh0 < 97 GeV remains. We present the predicted sparticle mass spectrum as a function of the gluino mass mg.
The Adaptive Markets Hypothesis

One of the most influential ideas in the past 30 years is the efficient markets hypothesis, the idea that market prices incorporate all information rationally and instantaneously. The emerging discipline of behavioral economics and finance has challenged the EMH, arguing that markets are not rational, but rather driven by fear and greed. Research in the cognitive neurosciences suggests these two perspectives are opposite sides of the same coin. An adaptive markets hypothesis that reconciles market efficiency with behavioral alternatives applies the principles of evolution? competition, adaptation, and natural selection? to financial interactions. Extending Simon's notion of ? satisficing? with evolutionary dynamics, the author argues that much of what behaviorists cite as counter-examples to economic rationality? loss aversion, overconfidence, overreaction, mental accounting, and other behavioral biases? is in fact consistent with an evolutionary model of individual adaptation to a changing environment via simple heuristics. The adaptive markets hypothesis offers a number of surprisingly concrete implications for portfolio management.
On Bohr-Sommerfeld bases

This paper combines algebraic and Lagrangian geometry to construct a special basis in every space of conformal blocks, the Bohr-Sommerfeld (BS) basis. We use the method of Borthwick-Paul-Uribe [3], in which every vector of a BS basis is determined by some half-weight Legendrian distribution coming from a Bohr-Sommerfeld fibre of a real polarization of the underlying symplectic manifold. The advantage of BS bases (compared to the bases of theta functions in [23]) is that we can use the powerful methods of asymptotic analysis of quantum states. This shows that Bohr-Sommerfeld bases are quasiclassically unitary. Thus we can apply these bases to compare the Hitchin connection [11] and the KZ connection defined by the monodromy of the Knizhnik-Zamolodchikov equation in the combinatorial theory (see, for example, [14] and [15]).
A practical software-only noncausal predictive video codec for low-bit-rate multimedia applications

A new coding scheme for bit rates below 150 Kb/s is proposed. The scheme combines (i) three-dimensional (3D) noncausal recursive prediction, (ii) vector quantization, and (iii) conditional replenishment. The 3D noncausal prediction model provides an alternative to causal (or unilateral) prediction, yet is not commonly used since it precludes recursive computations owing to its bilateral nature. This paper shows how to obtain a practical, near-optimal recursive implementation of the 3D noncausal video model and demonstrates its application in video compression. The proposed video codec is shown to produce high-quality compressed video at bit rates below 150 Kb/s. In contrast to the International Telecommunication Union (ITU) H.263 standard, the video codec exhibits acceptable video quality with a higher peak signal to reconstructed noise ratio (PSNR).
Myeloid-Derived Suppressor Cells

Myeloid cells developed evolutionarily as a major mechanism to protect the host. They evolved as a critical barrier against infections and are important contributors to tissue remodeling. However, in cancer, myeloid cells are largely converted to serve a new master—tumor cells. This process is epitomized by myeloid-derived suppressor cells (MDSC). These cells are closely related to neutrophils and monocytes. MDSCs are not present in the steady state of healthy individuals and appear in cancer and in pathologic conditions associated with chronic inflammation or stress. These cells have emerged as an important contributor to tumor progression. Ample evidence supports a key role for MDSCs in immune suppression in cancer, as well as their prominent role in tumor angiogenesis, drug resistance, and promotion of tumor metastases. MDSCs have a fascinating biology and are implicated in limiting the effects of cancer immunotherapy. Therefore, targeting these cells may represent an attractive therapeutic opportunity. Cancer Immunol Res; 5(1); 3–8. ©2016 AACR.
Clinical Trials and Treatment of ATL

ATL is a distinct peripheral T-lymphocytic malignancy associated with human T-cell lymphotropic virus type I (HTLV-1). The diversity in clinical features and prognosis of patients with this disease has led to its subtype-classification into four categories, acute, lymphoma, chronic, and smoldering types, defined by organ involvement, and LDH and calcium values. In case of acute, lymphoma, or unfavorable chronic subtypes (aggressive ATL), intensive chemotherapy like the LSG15 regimen (VCAP-AMP-VECP) is usually recommended if outside of clinical trials, based on the results of a phase 3 trial. In case of favorable chronic or smoldering ATL (indolent ATL), watchful waiting until disease progression has been recommended, although the long-term prognosis was inferior to those of, for instance, chronic lymphoid leukemia. Retrospective analysis suggested that the combination of interferon alpha and zidovudine was apparently promising for the treatment of ATL, especially for types with leukemic manifestation. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is also promising for the treatment of aggressive ATL possibly reflecting graft versus ATL effect. Several new agent trials for ATL are ongoing and in preparation, including a defucosylated humanized anti-CC chemokine receptor 4 monoclonal antibody, IL2-fused with diphtheria toxin, histone deacetylase inhibitors, a purine nucleoside phosphorylase inhibitor, a proteasome inhibitor, and lenalidomide.
WiZizz: Energy efficient bandwidth management in IEEE 802.11ac wireless networks

In this paper, we propose a new power save operation as well as the corresponding protocol, called WiFi in Zizz (WiZizz), which judiciously exploits the characteristic of the channel bonding defined in IEEE 802.11ac and efficiently handles the channel bandwidth in an on-demand manner to minimize the traumatic energy spent by IEEE 802.11ac devices. Our extensive measurement and simulation show significant performance improvement (up to 73% energy saving) over a wide range of communication scenarios. In addition, the feasibility of easy implementation is demonstrated by a prototype with a commercial 802.11ac device. To the best of our knowledge, WiZizz is the first IEEE 802.11ac-congenial energy efficient bandwidth management while other existing approaches require costly modifications of the IEEE 802.11ac specification.
Networks on Road-Challenges in Securing Vehicular Ad hoc Networks

The fundamental component for the success of VANET (Vehicular Ad hoc NETworks) applications is routing since it must efficiently handle rapid topology changes and a fragmented network. On demand set up, fault tolerance and unconstrained connectivity are a couple of advantages that why mobile computing continues to enjoy rapid growth.However, it can be expected that security attacks are likely to increase in the coming future due to the more and more wirelss applications being developed and deployed on to the well-known expose nature of wireless medium. Thanks to the substantial research efforts carried out by the community so far, we make the following contribution in this paper. In this paper we are specifically taking real life application of mobile ad-hoc networks i.e. VANET (vehicular adhoc networks). We will present a novel infrastructure for vehicle communication on highway and propose some potential security challenges from a driver’s perspective and car manufacturer’s . We will introduce an exemplary approach to outline various challenges and some possible solution.