Miracle-dz/UniFAR-FTUs huggingface dataset:
Job strain and high work demands and lack of opportunity to control work are related to increased risk of coronorary heart disease in British government employees

Familial Mediterranean fever (FMF) is an autosomal recessive disorder that affects primarily Jews, Armenians, Turks, and Arabs. It is characterised by recurrent, self limited attacks of fever accompanied by inflammation of the peritoneal, synovial, and pleural surfaces.1 Pericardial involvement is a well known (0.7–1.4%) but rare feature of the disease.2,3 Our initial observation of two patients who had recurrent pericarditis as a sole manifestation of FMF4 has led us to suggest that pericardial inflammation is more prevalent than generally believed. Since echocardiography is a non-invasive and sensitive tool for the detection of pericardial effusion, we undertook an echocardiographic study to assess the exact frequency of pericardial effusions during attacks of FMF. Two dimensional, M mode, and Doppler echocardiographic examinations were performed during 55 consecutive FMF attacks in 42 patients (15 female, 17 male). Echocardiographic study was carried out by one of the authors (ET or SA) and reviewed by the other one, who was aware of the diagnosis of FMF but unaware of the presence or absence of chest pain. Typical attacks of FMF consisted of fever and serositis including peritoneum, synovium, and pleura lasting 1–4 days. Attacks of FMF were recurrent and self limited. FMF was diagnosed according to established clinical criteria or molecular analysis when appropriate (in 37 patients). 1 None of the patients had …
Effect of Extrusion Process Parameters and Particle Size of Sorghum Flour on Expanded Snacks Prepared Using Different Varieties of Sorghum （Sorghum bicolour L.）

Sorghum is a staple food grain in many semi-arid and tropic areas of the world, because of its good adaptation to hard environments and its good yield of production. Among important biochemical components for sorghum processing are levels of starch and starch depolymerizing enzymes. Due to presence of high amount of starch (56%-73%), sorghum could be the good candidate for manufacturing of expanded snacks. The effect of various extrusion process parameters on structural and functional properties of extruded snacks prepared using three selected varieties of sorghum including SPV 1411 (Parbhani moti) and SPV 1595 (Parbhani jyoti) (newly developed varieties) and M-35-1 (Maldandi) were investigated in this study. Sorghum flour of different particle size viz. 2, 0.84 and 0.49 mm, was subjected to different extrusion processing conditions: feed moisture content (16%-24%), die temperature (110-150 °C), screw speed (150-270 rpm) and feed rate (50-120 g min). The feed moisture and die temperature (process variables) showed significant effect on the physical properties. This process parameter also increased dietary fibre with decrease in the content of tannins. Box-behnken design was successfully used to show a relationship between extrusion processing conditions and physical properties of extrudates. The extrudates obtained using SPV 1411, a variety of sorghum, showed significant results in all attributes compared to SPV 1595 and M-35-1, at feed moisture 22%, die temperature 130 °C and screw speed 210 rpm with 90% overall acceptability.
Reactive power optimization with different objectives in large power systems including HVDC systems and FACTS devices

Present day power systems are growing in size and complexity of operation with inter connections to neighboring systems, introduction of large generating units, EHV 400/765kV AC transmission systems, HVDC systems and more sophisticated control devices such as FACTS. For planning and operational studies, it requires suitable modeling of all components in the power system, as the number of HVDC systems and FACTS devices of different type are incorporated in the system. This paper presents reactive power optimization with three objectives to minimize the sum of the squares of the voltage deviations (ve) of the load buses, minimization of sum of squares of voltage stability L-indices of load buses (ΣL2), and also the system real power loss (Ploss) minimization. The proposed methods have been tested on typical sample system. Results for Indian 96-bus equivalent system including HVDC terminal and UPFC under normal and contingency conditions are presented.
Characterizing and Predicting Corrections in Spoken Dialogue Systems

This article focuses on the analysis and prediction of corrections, defined as turns where a user tries to correct a prior error made by a spoken dialogue system. We describe our labeling procedure of various corrections types and statistical analyses of their features in a corpus collected from a train information spoken dialogue system. We then present results of machine-learning experiments designed to identify user corrections of speech recognition errors. We investigate the predictive power of features automatically computable from the prosody of the turn, the speech recognition process, experimental conditions, and the dialogue history. Our best-performing features reduce classification error from baselines of 25.7028. 99% to 15.72%.
Cytomegalovirus infection induces high levels of cyclins, phosphorylated Rb, and p53, leading to cell cycle arrest

Human cytomegalovirus (HCMV) infection stimulates cellular DNA synthesis and causes chromosomal damage. Because such events likely affect cellular proliferation, we investigated the impact of HCMV infection on key components of the cell cycle. Early after infection, HCMV induced elevated levels of cyclin E, cyclin E-associated kinase activity, and two tumor suppressor proteins, p53 and the retinoblastoma gene product (Rb). The steady-state concentration of Rb continued to rise throughout the infection, with most of the protein remaining in the highly phosphorylated form. At early times, HCMV infection also induced cyclin B accumulation, which was associated with a significant increase in mitosis-promoting factor activity as the infection progresses. In contrast, the levels of cyclin A and cyclin A-associated kinase activity increased only at late times in the infection, and the kinetics were delayed relative to those for cyclins E and B. Analysis of the cellular DNA content in the infected cells by flow cytometry showed a progressive shift of the cells from the G1 to the S and G2/M phases of the cell cycle, leading to an accumulation of aneuploid cells at late times. We propose that these HCMV-mediated perturbations result in cell cycle arrest in G2/M.
Recovering binary class relationships: putting icing on the UML cake

A discontinuity exists between object-oriented modeling and programming languages. This discontinuity arises from ambiguous concepts in modeling languages and a lack of corresponding concepts in programming languages. It is particularly acute for binary class relationships---association, aggregation, and composition. It hinders the traceability between software implementation and design, thus hampering software analysis. We propose consensual definitions of the binary class relationships with four minimal properties---exclusivity, invocation site, lifetime, and multiplicity. We describe algorithms to detect automatically these properties in source code and apply these on several frameworks. Thus, we bridge the gap between implementation and design for the binary class relationships, easing software analysis.
Validity and Applications of the Montreal Cognitive Assessment for the Assessment of Vascular Cognitive Impairment

Cognitive impairment is common among patients with stroke or other cerebrovascular disease and influences long-term outcome, including occupational functioning. Recognition and monitoring of mild cognitive impairment is thus essential to good patient care. The Montreal Cognitive Assessment (MoCA) has been suggested as a brief screening test of vascular cognitive impairment. This paper presents a critical review of the research literature evaluating the validity and utility of this test with the aim of informing future clinical and research practice. A total of 30 papers employing the MoCA in the context of cerebrovascular disease were identified. Reporting of the methods and results of such studies tended to fall short of the established reporting guidelines. Under-specification of the exclusion criteria applied and their impact make it difficult to assess the potential impact of sampling bias and loss to follow-up. Nevertheless, content validity evidence suggests that the MoCA covers most of the domains that represent cognitive impairment in cerebrovascular disease, with mixed evidence for its preferential sensitivity to the type of cognitive impairment encountered in the context of vascular disease. Evidence clearly supports the need to establish norms and cut-offs for the MoCA that are culturally appropriate and that are matched to the range of cognitive impairment that is present in the population being assessed. Recent modifications of the MoCA have been developed for assessing patients with visual impairment or restricted mobility, which may reduce the impact of ‘untestability' on cognitive screening in the clinic or research context. The MoCA correlates well with other measures of cognitive and functional abilities in patients with cerebrovascular disease, and may also predict future response to rehabilitation and long-term occupational outcome. Further research is needed to provide evidence for the validity of the MoCA in longitudinal studies. However, it compares favourably to the Mini Mental State Examination as a screening test that is sensitive to the milder forms of cognitive impairment that often accompany cerebrovascular disease.
Human tumor xenografts recurring after radiotherapy are more sensitive to anti-vascular endothelial growth factor receptor-2 treatment than treatment-naive tumors.

The effects of antiangiogenic therapy on tumors relapsing after irradiation are not known. To this end, we irradiated human tumors growing s.c. in nude mice with a single dose of 20 or 30 Gy. Compared with primary (treatment-naive) xenografts, the growth rate of recurrent tumors was 1.6-fold slower, which is consistent with the known "tumor bed effect. " For similar size tumors, recurrences had fewer functional vessels, a reduced vessel coverage by perivascular cells, and were more necrotic. Placenta growth factor concentration was significantly lower in relapses, whereas vascular endothelial growth factor (VEGF) levels were similar between primary and recurrent tumors. On the other hand, fibrillar collagen deposition was significantly increased in recurrent tumors. This radiation-induced fibrosis was partially responsible for the slower growth of recurrences; the i.t. injection of collagenase increased the growth rate of tumor relapses without affecting primary tumor growth. The mouse-specific VEGF receptor 2-blocking antibody DC101 induced a 2.2-fold longer growth delay in recurrent tumors compared with treatment-naive tumors. DC101 significantly decreased the interstitial fluid pressure and did not change the functional vessel density and perivascular cell coverage in both tumor variants. Interestingly, DC101 induced a rapid (2 days after treatment initiation) and significant decrease in tumor cell proliferation in recurrent but not in primary tumors. Thus, our results show that the stromal compartment and the response to antiangionenic therapy of primary and in-field recurrent tumors are significantly different. Our findings suggest that antiangiogenic agents could be effective in the treatment of patients with relapses after radiotherapy.
Efecto de agentes hemostáticos en la capacidad de sellado marginal de restauraciones clase 5.

Restorations longevity may be affected by contamination during the adhesion process. This study aimed to evaluate hemostatic agents’ contamination effect on the marginal sealing capability of two restorative materials. Materials and methods: 30 extracted third molars were randomly distributed into 6 groups for an in vitro microleakage effect: G1 Composite resin (CR) (Te-Econom Plus® + Te-Econom Bond® Ivoclar Vivadent®/ Schaan, Liechtenstein), G2glass ionomer + polyacrylic acid (GI) (Riva Light®, SDI®/®/Bayswater, VIC, Australia + Fuji II®, GC®/Tokyo, Japan), G3 CR+ferric sulfate (ferricsulfate al 20%, ViscoStat®, Ultradent Products Inc.®/South Jordan, USA), G4 CR+aluminum chloride (ViscoStat® Clear, Ultradent Products Inc.®/South Jordan, USA), G5GI+ferric sulfate, G6GI+aluminum chloride. Class V cavities were prepared and restored on vestibular and lingual cervical areas involving enamel and dentine. Samples were stored at 37 oC for 10 days and then immersed in 0.5% methylene blue for 24 hours. Lastly, samples were sectioned vestibule-lingual and the exposed microleakage scanned and measured in µm. One-way ANOVA at three levels (Group and location) was used at a=0.05. Results: Groups microleakage mean (SD) were: G2= 769.5 (537.3) µm; G5= 690 (510) µm; G4=535 (732.2) µm; G6=530 (448) µm; G3 487.5 (722.9) µm, higher than G1 177.5 (509.6) µm, (p= 0.001). Being cementum/dentin=665 (708.5) µm greater than enamel= 395.83 (456,8) µm (p= 0,001). Intersection group-location was different at p= 0,001; since G5 and G6 (both contaminated) improved sealing capability compared to G1. Conclusion: Under the conditions of the present study, ferric sulfate and aluminum chloride negatively affect composite resin´s sealing capability at the cementum/dentin level, but not the one of glass ionomer at any location.
SiSPED 2.0: An extension of a system to monitor diabetic patients

Diabetes Mellitus is a chronic degenerative disease accepted as a worldwide epidemic. The diabetic foot is one of the most fearful complications of diabetic patients and is responsible for fifty percent of non-traumatic lower-extremity amputations in general hospitals. Foot complications in diabetic patients can be prevented, in most of the cases, by submitting patients to continuous foot examinations and to a personal reeducation process. This paper describes an extension of SiSPED, a system to monitor patients with the possibility of developing the diabetic foot. In this extension the system has been entirely redesigned and new technologies are used to improve performance and maintainability. In addition, the rules applied to generate automatically a diagnostic report are updated to follow international guidelines applied in the diabetic foot prevention. The system also allows the correlation of patient data, essential to measure the impact of the methodology for diabetic foot prevention on the assisted population.
The validity of indicators for assessing quality of care: a review of the European literature on hospital readmission rate.

BACKGROUND Quality indicators are increasingly being implemented in Europe for policy and management purposes. Many of these indicators were initially developed and implemented in the USA. However, the suitability of directly adopting indicators that have been developed in a different health care system can be questioned. Therefore, we investigate the validity behind the readmission rate indicator in the European setting. METHODS A systematic literature study was conducted to identify the status of scientific research on the validity of this indicator (January 1999 and April 2010). Descriptive information as well as information on the data source, indicator definition, risk adjustment factors, and conclusions was assessed. RESULTS The majority of the 486 included studies focused on the actual use of the indicator as an outcome measure in European countries. Only 21 studies specifically addressed its validity, or important prerequisites of validity. There is little consensus over the time-frame used to calculate the indicator, the type of readmission that is included, and the case-mix adjustment applied. CONCLUSIONS Despite the increase in Europe of the use of the readmission rate as a measure of quality of care, the amount of research performed on its validity is scarce. Those studies that report on validity replicate earlier, mainly US findings (<1999) of methodological problems and express reservations on its large-scale use. The readmission rate as an indicator should be used with care. Users should address issues related to definition, time-frame and case-mix adjustment as part of the process to enhance validity in the European settings.
Analysis of longitudinal and torsional resonance vibrations of a piezoelectrically excited bar by introducing piezoelectric loss coefficients

In this study, a method to develop a resonance vibration model of a piezo-bar with slanted ceramics is presented by considering piezoelectric loss coefficients. The vibration model reported here predicts natural frequencies and mode shapes for longitudinal and torsional modes. Analytical results for the longitudinal and torsional vibration displacements were formulated as a function of material and geometric properties. Parametrical analysis of the resonance vibration modes and the explicit solution of the vibration displacement provide a tool for improving the design and developing control schemes for devices such as ultrasonic motors that utilize this structure. Model calculations were compared with ATILA™ finite element analysis simulations and good agreements were found. The model and the formulas to find the resonance frequencies and to calculate the vibration displacement were verified for different design parameters. Although the model was developed for a slanted ceramic stator of a multimode ultrasonic motor, the method to develop the model can be utilized for other single-degree-of-freedom piezoelectric ceramic applications.
Investigation of selected properties of a resin-based root canal filling material -an in vitro study

Following chemo-mechanical cleaning of the root canal system, the provision of a fluid-tight seal is one of the main requirements for successful endodontic treatment. Gutta percha with a sealer has been considered as the gold standard root canal filling for many years. However, it does not have all the properties of an ideal root canal filling. A resin-based root filling, Resilon, has been introduced which has the advantage of bonding to the root canal dentine forming a ? monoblock? Different properties of Resilon have been investigated, but some properties using different obturation techniques and in retreatment need further investigation.The aim of this project was to investigate selected properties of Resilon in primary endodontic treatment (quality of obturation using either cold lateral condensation or thermal compaction, and push-out bond strength following the use of different intracanal medicaments) and secondary endodontic treatment (removability using a combination of hand and rotary instrumentation, fracture resistance and leakage resistance following different removal techniques). Using micro-CT, the volume of voids in root canals obturated with Resilon in comparison with gutta percha using either cold lateral condensation or thermal compaction was investigated. The results showed that there was no significant difference between the two materials regardless of the obturation technique.The use of Vitapex and iodoform was found to significantly reduce the bond strength of Resilon to dentine in comparison with calcium hydroxide and its aqueous combination with iodoform (Calcipast1). The effectiveness of the combined use of hand K-files and ProTaper retreatment files in removal of Resilon using either cold lateral condensation or thermal compaction was compared to that of gutta percha. Micro-CT assessment showed that Resilon resulted in significantly more remaining material than gutta percha when thermal compaction was used.Fracture resistance of retreated roots filled with Resilon was found to be not significantly different from those filled with gutta percha irrespective to the removal technique (either hand K-files or ProTaper retreatment files). Using the same retreatment techniques, dye leakage resistance of root canals re-filled with Resilon was compared with that of primarily treated root canals. The results showed that there was no significant difference in leakage resistance between re-treated and primarily treated root canals.Obturation with Resilon was shown to have no significant advantage over gutta percha in terms of quality of obturation and fracture resistance in retreated roots. More investigation of the clinical performance of Resilon is required before it can be considered as a replacement for gutta percha.
Nelarabine in the Treatment of Refractory T-Cell Malignancies

Nelarabine is a nucleoside analog indicated for the treatment of adult and pediatric patients with T-cell acute lymphoblastic leukemia (T-ALL) or T-cell lymphoblastic lymphoma (T-LBL) that is refractory or has relapsed after treatment with at least two chemotherapy regimens. After being first synthesized in the late 1970s and receiving FDA approval in 2005, the appropriate use of nelarabine for refractory hematologic malignancies is still being elucidated. Nelarabine is the prodrug of 9-β-D-arabinofuranosylguanine (ara-G) which when phosphorylated intracellularly to ara-G triphosphate (ara-GTP), preferentially accumulates in cancerous T-cells. Dose-dependent toxicities, including neurotoxicity and myelosuppression, have been documented and may, in turn, limit the ability to appropriately treat the diagnosed malignancy. This article will summarize the pharmacologic properties of nelarabine and will address the current place in therapy nelarabine holds based upon the results of the available clinical trials to date.
Structure-Activity Relationships Defining the Cytotoxicity of Catechol Analogues against Human Malignant Melanoma 1

The cytotoxic activities of three new synthetic catechol analogues, /H(p-hydroxyphenyl)amino|alanine (Compound 1), W-^-hydroxyphenyl)ornithine (Compound 2), and A^-i/n-hydroxyphenylJornithine (Compound 3), were determined against 10 human melanoma and 5 nonmelanoma cell lines. Activities of L-DOPA and 3,4-dihydroxybenzylamine were also measured. Dose-response curves were obtained and concentrations in w ml required to give 90% inhibition of colony forma tion (H '.â€ž,) were calculated. Using a cutoff K Â«, of <2.5 as a definition of activity, Compound 2 was active in 6 of 10 melanoma and 0 of 5 nonmelanoma cell lines while both Compound 1 and L-DOPA methyl ester were active in 1 of 10 melanomas and 0 of 5 nonmelanomas. Compound 3 was inactive in all cell lines and all ICw values exceeded 100. 3,4-Dihydroxybenzylamine was active in 3 of 8 melanomas and 1 of 5 nonmelanomas. Regression analysis of ICw values for Compound 2 and tyrosinase levels in the 15 cell lines yielded a correlation coefficient of 0.93 (/' < 0.001). By contrast, a similar analysis for 3,4-dihydroxybenzylamine gave a correlation coefficient of 0.17 (P > 0.05). Spectrophotometric data indicated that Compounds 1 and 2 were oxidized by tyrosinase to quiÃ±ones. Cytotoxic activity was blocked by the tyrosinase inhibitor phenylthiocarbamide. Since the rates of activation of Com pounds 1 and 2 were identical, the higher activity of Compound 2 was probably due to its higher lipophilicity and greater intracellular accu mulation. Compounds 1 and 2 exhibited greater potency and selectivity against malignant melanoma than did the natural product L-DOPA methyl ester.