Miracle-dz/UniFAR-FTUs huggingface dataset:
Closed-Loop Insulin Delivery Using a Subcutaneous Glucose Sensor and Intraperitoneal Insulin Delivery

OBJECTIVE Attempts to build an artificial pancreas by using subcutaneous insulin delivery from a portable pump guided by an subcutaneous glucose sensor have encountered delays and variability of insulin absorption. We tested closed-loop intraperitoneal insulin infusion from an implanted pump driven by an subcutaneous glucose sensor via a proportional-integral-derivative (PID) algorithm. RESEARCH DESIGN AND METHODS Two-day closed-loop therapy (except for a 15-min premeal manual bolus) was compared with a 1-day control phase with intraperitoneal open-loop insulin delivery, according to randomized order, in a hospital setting in eight type 1 diabetic patients treated by implanted pumps. The percentage of time spent with blood glucose in the 4.4–6.6 mmol/l range was the primary end point. RESULTS During the closed-loop phases, the mean ± SEM percentage of time spent with blood glucose in the 4.4–6.6 mmol/l range was significantly higher (39.1 ± 4.5 vs. 27.7 ± 6.2%, P = 0.05), and overall dispersion of blood glucose values was reduced among patients. Better closed-loop glucose control came from the time periods excluding the two early postprandial hours with a higher percentage of time in the 4.4–6.6 mmol/l range (46.3 ± 5.3 vs. 28.6 ± 7.4, P = 0.025) and lower mean blood glucose levels (6.9 ± 0.3 vs. 7.9 ± 0.6 mmol/l, P = 0.036). Time spent with blood glucose <3.3 mmol/l was low and similar for both investigational phases. CONCLUSIONS Our results demonstrate the feasibility of intraperitoneal insulin delivery for an artificial β-cell and support the need for further study. Moreover, according to a semiautomated mode, the features of the premeal bolus in terms of timing and amount warrant further research.
Three-dimensional nonrigid registration and fusion for image-guided surgery navigation system

High Intensity Focused Ultrasound (HIFU) system has been successfully applied to the tumor therapy. It is crucial to localize the tumor region accurately in this system. In this paper, a semi-automatic non-rigid registration algorithm is presented to implement the image-guided surgery navigation and localization by registration of pre-operative CT/MRI images and intra-operative US images. The global motion of object is modeled by an affine transformation while the local deformation is described by Free-Form Deformation (FFD) based on B-splines. By experiments on simulated and real data, the registration results show that new registration algorithm is appropriate for clinical applications, and can satisfy the requirements of localization system of HIFU. It also indicates that image-guided surgery navigation technique has potential use in HIFU therapy system using our registration algorithm.
NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region

BCL2 protein functions as an inhibitor of cell apoptosis and has been found to be aberrantly expressed in a wide range of human diseases. A highly GC-rich region upstream of the P1 promoter plays an important role in the transcriptional regulation of BCL2. Here we report the NMR solution structure of the major intramolecular G-quadruplex formed on the G-rich strand of this region in K+ solution. This well-defined mixed parallel/antiparallel-stranded G-quadruplex structure contains three G-tetrads of mixed G-arrangements, which are connected with two lateral loops and one side loop, and four grooves of different widths. The three loops interact with the core G-tetrads in a specific way that defines and stabilizes the overall G-quadruplex structure. The loop conformations are in accord with the experimental mutation and footprinting data. The first 3-nt loop adopts a lateral loop conformation and appears to determine the overall folding of the BCL2 G-quadruplex. The third 1-nt double-chain-reversal loop defines another example of a stable parallel-stranded structural motif using the G3NG3 sequence. Significantly, the distinct major BCL2 promoter G-quadruplex structure suggests that it can be specifically involved in gene modulation and can be an attractive target for pathway-specific drug design.
Process Identification - Problem of the Data Filtering using Dynamic Particles Method

In a disc brake assembly of the pin slide type including a stationary support member mounted on a vehicle body structure and having at least one support pin secured thereto, a caliper member having a boss portion slidably supported on the support pin to be movable in an axial direction, and a tubular elastic boot arranged in surrounding relationship with the support pin to enclose a sliding portion on the same, a cylindrical protector with a closed end is arranged in surrounding relationship with the tubular elastic boot and fixed in place by engagement with the outer end portion of the support pin or a member secured thereto in such a way to contain therein the tubular elastic boot, the outer end portion of the support pin and its associated members.
Approximate Inference in Deep GPs

In this talk we will review deep Gaussian process models and relate them to neural network models. We will then consider the details of how variational inference may be performed in these models. The approach is centred on “variational compression”, an approach to variational inference that compresses information into an augmented variable space. The aim of the deep Gaussian process framework is to enable probabilistic learning of multi-modal data. We will therefore end by highlighting directions for future research and discussing application of these models in domains such as personalised health.
Computer vision for systems biology

This short paper introduces the scope of our special emphasis session on computer vision for systems biology. It attempts to define the needs for computer vision based readouts in systems biological research and to shed light on some of the challenges computer vision researchers should tackle for the systems biology community. Finally, it will give a short overview of the invited and contributed papers that will be presented in this session
A Survey of Social Science Journal Editors for Behind-the-Scenes Data on the Publication Process

Conducting and publishing research is at the heart of the academic social scientist’s job. Understanding the publication process is critical for any scholar looking for a successful career. The current study draws on survey data from 117 editors of social science journals to identify how editors experience their jobs, how manuscript reviews are processed, and what aspects of editors, journals, and manuscripts are most important to editors’ publication decisions. Results suggest that editors relied on their editorial boards and associate editors to do reviews and give advice, that the greatest challenge editors faced in dealing with manuscripts was slow reviewers, and that rarely did editors face allegations of plagiarism or have to deal with inappropriate reviews they did not want to send to the author(s). Quality of writing and strength of findings are the most influential factors in journals’ acceptance rates.
Muscle‐specific expression of the acetylcholine receptor alpha‐subunit gene requires both positive and negative interactions between myogenic factors, Sp1 and GBF factors.

The dependence of the muscle‐specific enhancer of the acetylcholine receptor alpha‐subunit gene on other domains of the promoter has been analysed by performing point mutagenesis and modular reconstitution of the enhancer‐‐promoter sequences. The enhancer is inactive in the absence of the proximal region containing an Sp1 binding site and an overlapping G‐C homopolymer binding factor site (referred to as GBF). The proximal region can be replaced by an Sp1 binding site from SV40 or an MEF‐2 binding site from the muscle creatine kinase gene. Specific mutation of the Sp1 site markedly affects transactivation by CMD1 or myogenin. Mutation of the GBF binding site leads to higher promoter activity in primary cultures of chick myotubes or in quail fibroblasts. In addition, binding of a purified Sp1 protein prevents the binding of GBF in vitro. It is proposed that in the case of the alpha‐subunit promoter, the myogenic factors activate transcription in cooperation with Sp1, and that GBF contributes to muscle‐specific expression of the promoter by interfering with Sp1 binding in nonmuscle muscle cells or myoblasts.
The Needles in the Haystack Survey: searching for X-ray-selected normal galaxies

In this paper we present the first results from an ongoing serendipitous survey aiming to identify X-ray-selected 'normal' galaxies [i.e. not dominated by active galactic nuclei (AGNs)] by combining archival XMM-Newton data with the Sloan Digital Sky Survey. In the first 4.5 deg 2 of this program, we have identified a total of 11 'normal' galaxy candidates (eight of them with optical spectroscopy) with fluxes f X (0.5-8 keV) 10 -15 -10 -13 erg s -1 cm -2 . These sources are selected to have low X-ray-to-optical flux ratio (log f X /f opt ≤ -2), soft X-ray spectral properties and optical spectra, when available, consistent with the presence of a stellar ionizing continuum. These sources comprise both early- and late-type systems at redshifts z ≤ 0.2 with luminosities L X (0.5-8 keV) 10 39 -10 42 erg s -1 . This data set provides the first tight constraint on the surface density of X-ray-selected 'normal' galaxies at relatively bright fluxes spanning 2 orders of magnitude (10 -15 -10 -13 erg s -1 cm -2 ). The slope of the 'normal' galaxy log N-log S relation in the above flux range is estimated to be -1.4 ± 0.3, consistent with the Euclidean prediction. We also discuss the prospects of 'normal' galaxy studies at X-ray wavelengths using both our continuously expanding survey and future X-ray missions.
Implementation and evaluation of a national external quality control program for cervical cytology in Mexico.

OBJECTIVE To evaluate cytology laboratories and the performance of cytotechnologists for establishing efficient external quality control for Mexico's National Program for the Prevention and Control of Cervical Cancer. MATERIAL AND METHODS During January and February 1998, an onsite evaluation of all cytology laboratories of the Ministry of Health found that only 70% of the microscopes were in adequate working conditions, reagents were out of date, and working conditions were sub-optimal. A program for external quality control based on proficiency testing was established for cytotechnologists. Fifty slide sets with 20 Papanicolaou slides and 10 photographic slides were prepared. The sets were given to the cytotechnologists for evaluation and again one year later by courier. RESULTS Twenty-one percent of microscopes were repaired and 9% replaced; reagents were distributed and laboratory facilities improved. Only 16% of cytotechnologists passed the initial proficiency test. Cytotechnologists received a refresher training course: one year later 67% of them passed the proficiency test. To ascertain that each slide was correctly diagnosed, 41 sets were rescreened by expert cytopathologists or cytologists and their diagnoses compared to the original ones. Thirty-seven sets had 86% to 96% concordance. CONCLUSIONS This new system for external quality control of cervical cytology allowed the opportune and reliable evaluation of the performance of cytotechnologists.
Towards a demand driven, autonomous processing and streaming architecture

This paper describes SOPA, a component framework that is an essential part of the lecture recording system E-Chalk. It envisages a general processing and streaming architecture featuring autonomous assembly of stream-processing components. The goal is to provide an easy to use framework where dynamically organized processing graphs are constructed from components of various distributed sources. Based on state-of-the-art solutions for component based software development, the system simplifies the implementation and configuration of multimedia streaming applications and associated tools. It supports stream synchronization transparently, while extending components are installed on the fly to meet existing requirements that may change at any time.
Image Speckle Reduction and Coherence Enhancement in Underwater Ultrasonic Imaging Based on Wavelet Transform

In order to reduce the underwater ultrasonic image speckles and to enhance the image characteristics, an anisotropic diffusion model is established based on the wavelet transform in this paper. At the same time, it also provides the steps of the algorithmic architecture and analyzes the key links of the model during its application. Two-check experiments have been done using simulation data and real underwater ultrasonic image respectively. In experiment a compare research for underwater ultrasonic image has been done using the method and other traditional methods. After performing the WLAD-model-based image speckle reduction and coherence enhancement to the underwater ultrasonic image, we find that this algorithm has the ability to remove the image speckles and enhance the edges. This algorithm can well be applied to removing the speckles and enhancing the edges in the underwater ultrasonic image.
The contribution of smoking to socioeconomic differentials in mortality: results from the Melbourne Collaborative Cohort Study, Australia

Objective: To assess the contribution of smoking to the inverse association of mortality with years of formal education in men in Australia. Design: Data were obtained from a prospective cohort study that included 17 049 men in Melbourne recruited from 1990 to 1994, most of whom were aged between 40 and 69 years at baseline. The outcome measured was all-cause mortality. The contribution of smoking to socioeconomic status differentials was estimated by including smoking as a variable in a Cox’s proportional hazards model that also included education and other potential confounding variables. Results: In men, the association between education and mortality was attenuated after adjustment for smoking, and the aetiological fraction for low levels of education was reduced from 16.5% to 10.6%. Conclusions: In men, smoking contributes substantially to socioeconomic differentials in mortality. Effective policies and interventions that target smoking among socially disadvantaged groups may substantially reduce socioeconomic differentials in health.
Goal-Oriented Auditing and Logging

Matt Bishop Christopher Wee Jeremy Frank Department of Computer Science University of California at Davis Davis, CA 95616-8562 This paper presents a technique for deriving audit requirements from security policy, with examples for informal specifications. Augmenting these requirements with a system model allows an analyst to determine specifi c functions within the system that must be audited. We demonstrate the effectiveness of this technique by deriving audit criteria for the Netw ork File System, and show that the results would detect numerous well-kno wn attacks upon implementations of that protocol.
Interrelationships between visual-motor integration, visual perception, motor coordination and object control skills of Grade 1-learners : NW-child study

The aim of this study was to determine the interrelationship of visual-motor integration, visual perception and motor coordination with object control skills in Grade 1-learners in the North-West Province of South Africa. This study is based on only the baseline data of a longitudinal study (NW-CHILD study) in progress. The Grade 1-learners (N=806) had a mean age of 6.84±0.39 years. The Developmental Test of Visual-Motor Integration (4th ed.) (VMI), was used to evaluate visual skills, while the Test of Gross Motor Development-2 evaluated six object control skills. There was a statistical significant (p≤0.01) association between VMI, two object control skills and total score for object control skills. Visual perception had the highest correlation with all the object control skills where a statistically significant (p≤0.05) association with five object control skills and the total score was obtained. Motor coordination had small but significant correlations with two object control skills. Understanding the influence that VMI, visual perception and motor coordination have on ball handling skills should enable practitioners to address them appropriately during the early years.
An integrated approach of KSF evaluation and service selection for social games based on players' behavior

Due to the enhancement of web service and people's love needs, social networking service is emerging and getting more and more popular in recent years. Recently, social games have been drawing much attention. Social games contributed more people to play online games, and to extend their social networks. The popularity of social games also changed the operation model of online games. High production cost online games are threatened by low-cost website-recommended-only social games. Thus, it is very important for the on-line game service providers to find out the key factors influencing player's decision. Currently, there are various kinds of social games, for instance, harvest and farm (Happy Harvest, Country Story, and Farm Vills), Pet breed (Pet Society and My Fishbowl), and the category of Restaurant and inn management (Restaurant City and Café World). In this study, the Fuzzy cognitive map (FCM) is used to construct the network relation map (NRM) and the extended NRM, the Principal component Analysis (PCA) is applied to categorize criteria based on their properties, the Analytic network process (ANP) is used to determine the weights of components, and the VIKOR (Vlse kriterijumska Optimizacija I Kompromisno Resenje) is adopted to evaluate the performance gaps of social games. Service provider of social games could clarify the relationship between the service performance and the behavior of use, and obtain improvement strategies of service performance for social game service.
Optimal Sequencing Via Modular Decomposition: Characterization of Sequencing Functions

With the recent development of efficient algorithms for locating modules in a precedence network, a new class of sequencing algorithms has become promising. These algorithms obtain optimal sequences by finding optimal subsequences of progressively larger modules, until all jobs are sequenced. To guarantee optimality of resulting sequences, the sequencing (objective) function must satisfy the “job module property” defined herein. In this paper, three properties of sequencing functions are defined, and it is shown that a sequencing function satisfying these properties possesses the job module property; many other decomposition results previously shown by the second author to hold for the total weighted completion time problem follow as well. Moreover, the class of problems defined by these sequencing functions includes the total weighted completion time problem, the least-cost fault detection problem, and the total weighted exponential completion time problem.
Who Is there? Can a Virtual Agent Really Elicit Social Presence?

This study investigates whether humans perceive a higher degree of social presence when interacting with an animated character that displays natural as opposed to no listening behaviors and whether this interacts with people’s believe that they are interacting with an agent or an avatar. In a 2x2 between subjects experimental design 83 participants were either made believe that they encounter an agent, or that they communicate with another participant mediated by an avatar. In fact, in both conditions the communication partner was an autonomous agent that either exhibited high or low behavioral realism. We found that participants experienced equal amounts of presence, regardless of interacting with an agent or an avatar. Behavioral realism, however, had an impact on the subjective feeling of presence: people confronted with a character displaying high behavioral realism reported a higher degree of mutual awareness. Keywords---virtual agents, avatars, social presence, experimental study, behavioral realism
Implementation and Evaluation of a Values Clarification Activity for a Large Undergraduate Human Sexuality Course

ABSTRACT Values clarification is an important tool that helps individuals to clarify their beliefs about sexuality-related issues. This lesson plan provides instructions for a 1-hour values clarification activity for a large undergraduate human sexuality course that serves as an introduction to course content and tone, stimulates students' initial thinking about course topics, and demonstrates the diversity of perspectives on sexuality-related issues. Survey-based evaluation findings (N = 71) establish that the activity successfully meets its learning objectives and that students feel comfortable participating. Step-by-step directions, recommendations for facilitation, and reflections on best practices for the activity are provided.
A novel PI3K inhibitor PIK-C98 displays potent preclinical activity against multiple myeloma

Recent clinical trials have demonstrated targeting PI3K pathway is a promising strategy for the treatment of blood cancers. To identify novel PI3K inhibitors, we performed a high throughput virtual screen and identified several novel small molecule compounds, including PIK-C98 (C98). The cell-free enzymatic studies showed that C98 inhibited all class I PI3Ks at nano- or low micromolar concentrations but had no effects on AKT or mTOR activity. Molecular docking analysis revealed that C98 interfered with the ATP-binding pockets of PI3Ks by forming H-bonds and arene-H interactions with specific amino acid residues. The cellular assays demonstrated that C98 specifically inhibited PI3K/AKT/mTOR signaling pathway, but had no effects on other kinases and proteins including IGF-1R, ERK, p38, c-Src, PTEN, and STAT3. Inhibition of PI3K by C98 led to myeloma cell apoptosis. Furthermore, oral administration of C98 delayed tumor growth in two independent human myeloma xenograft models in nude mice but did not show overt toxicity. Pharmacokinetic analyses showed that C98 was well penetrated into myeloma tumors. Therefore, through a high throughput virtual screen we identified a novel PI3K inhibitor that is orally active against multiple myeloma with great potential for further development.
Multi-hop relay for next-generation wireless access networks

Recently, there has been an upsurge of interest in multi-hop relay in both academia and industry. By breaking a long distance low quality link into two or more high quality segments, multi-hop relay is introduced to enable traffic/signaling forwarding between the base station and mobile user. Coverage is effectively extended to heavily shadowed areas in the cell or other distant areas beyond cell range by multi-hop relay. Meanwhile, it also provides throughput enhancement, especially at the cell edge. This paper first reviews the key technical advances with multi-hop relay in cellular networks. Then, novel technical solutions and algorithms for multi-hop relay are introduced and analyzed, including the separation of control and data, effective signal-to-interference-plus-noise ratio (SINR)-based routing algorithms, and cooperative relay schemes. Through extensive system-level and link-level simulations, we present improvements in both capacity and coverage in multi-hop relay networks compared to the legacy cellular network.