Miracle-dz/UniFAR-FTUs huggingface dataset:
A Regular Expression Matching Algorithm Using Transition Merging

With the rapid development of the network, deep packet inspection systems are faced with the challenge of high performance. On one hand, they try to reduce the memory consumption in the process of regular expression matching; On the other hand, they must provide a worst-case matching speed guarantee. The existing state merging finite automata algorithm reduces the number of states in the deterministic finite automata (DFA). But there are still a large amount of transitions. In this paper, we introduce a transition merging finite automata algorithm, which merges several transitions in the DFA, based on the state merging algorithm. The experiments show that the transition merging algorithm reduces the memory consumption by 15%~31% compared to the state merging algorithm, when compared to the original DFA, it reduces the memory consumption by 25%~42%. At the same time, the transition merging algorithm ensures the matching speed. It is a memory efficient regular expression matching algorithm.
Two Class XI Myosins Function in Organelle Trafficking and Root Hair Development in Arabidopsis1[OA]

Multigene families encoding class XI myosins are conserved in higher plants, however, little information is available on specific functions of these ubiquitous molecular motors. We isolated gene knockout mutants for all 13 class XI myosins present in Arabidopsis (Arabidopsis thaliana) genome. Inactivation of 11 myosin genes resulted in no discernible phenotypes under the normal growth conditions. In contrast, the knockouts of the remaining two myosin genes, XI-2 (formerly MYA2) and XI-K, exhibited similar defects in root hair elongation suggesting that the myosin-driven motility plays a significant role in a polar tip growth. Strikingly, inactivation of each of these myosins also reduced trafficking of Golgi stacks, peroxisomes, and mitochondria in root hairs and in leaf epidermal cells. These results indicate that myosins XI-K and XI-2 play major and overlapping roles in the cell dynamics in Arabidopsis and highlight the redundant nature of myosin function in plants.
Biglycan and decorin induce morphological and cytoskeletal changes involving signalling by the small GTPases RhoA and Rac1 resulting in lung fibroblast migration

Biglycan and decorin are small chondroitin/dermatan sulphate proteoglycans in the extracellular matrix of connective tissue that belong to the family of structurally related proteoglycans called small leucine-rich repeat proteins. We show for the first time that biglycan and decorin induce morphological and cytoskeletal changes in fibroblasts, resulting in an increase in migration. Biglycan changed the cell shape of fibroblasts with formation of long protruding filamentous processes. This was also seen for decorin but to a lesser extent. Using fluorescence staining of F-actin fibres it was possible to show that these long filamentous processes were supported by long thick bundles of actin, together with an induced formation of stress fibres after stimulation with biglycan and decorin. Moreover, a reorganisation of α-smooth muscle actin was clearly seen in these cultures. Decorin also stimulated α-smooth muscle actin expression in the cells. Using cDNA Atlas Arrays we were also able to show that the mRNA level of a number of the intracellular regulators and effectors involved in cell migration were increased. For example, the focal adhesion proteins paxillin and zyxin, and some of the small Rho GTPases such as RhoA, Rac1 and Cdc42 were upregulated. After treatment with biglycan or decorin, additional results showed an increased activation of RhoA (1.8- and 1.5-fold, respectively) and Rac1 (1.8- and 1.5-fold, respectively) after 15 minutes. These factors are known to be involved in fibroblast migration, and as expected a 1.3- to 1.6-fold increase in migration could be observed after stimulation with biglycan or decorin. This induced migration was caused by the core protein, as treatment with glycosaminoglycan chains alone did not have any effect. In summary, these data indicate that biglycan- and decorin-induced fibroblast cytoskeletal and signalling changes result in an increased cell migration, and demonstrate their potential role in the remodelling process.
Frequency domain methods for optimal sensor placement and scheduling of spatially distributed systems arising in environmental and meteorological applications

We consider the problem of sensor placement (both spatial location and number) for a class of parameter-dependent diffusion-advection processes that model environmental processes. To distinguish between advection and diffusion dominated environmental processes, the Péclet number, Pe, which takes values over a set of a priori defined values, is utilized to optimize the number and spatial location of the sensors required. The minimum number of sensors is defined using system theoretic measures and essentially considers the smallest number of sensors that would render the system observable, thereby facilitating the design of a state observer. The optimization metric is defined with respect to the spatial H2 norm of the dominant system modes, which may differ for different values of Pe. For each value of Pe, a set of optimal sensor locations and number is found and the associated state estimator is designed. The supervisory scheme then schedules the sensors corresponding to the Péclet number that describes the process at a given time by pouting in sleep mode all sensors associated with a different value of Pe and activating the sensors that are optimal for the current value of Pe. At the same time, the state estimator also switches by using the filter gain corresponding to the current value of the Péclet number and the active sensors. Extensive simulation studies are included to provide further inside on parameter-dependent sensor and observer scheduling for environmental processes.
The Polymorphic Linker Domain of pfmdr1 Is Associated with Resistance-Conferring Mutations in Plasmodium falciparum Populations from East and West Africa

ABSTRACT Sequence variation in the asparagine/aspartate-rich domain of pfmdr1 in 215 isolates of Plasmodium falciparum from three African countries was compared with published data. The role of this domain in modulating antimalarial sensitivity has not been established. The pfmdr1 86Y allele was significantly associated with different configurations of the Asn/Asp-rich domain in West and East Africa. In Kenya, a specific form of the Asn/Asp-rich domain was significantly linked to the 86Y, 184Y, and 1246Y haplotype of pfmdr1.
DECISION TREE INDUCTION FOR FINANCIAL FRAUD DETECTION USING ENSEMBLE LEARNING TECHNIQUES

Credit card fraud is a serious and major growing problem in banking industries. With the advent of the rise of many web services provided by banks, banking frauds are also on the rise. Banking systems always have a strong security system in order to detect and prevent fraudulent activities of any kind of transactions. Though totally eliminating banking fraud is almost impossible, but we can however minimize the frauds and prevent them from happening by machine learning techniques. This paper aims to conduct experiments to study banking frauds using ensemble tree learning techniques and genetic algorithm to indict ensemble of decision trees on bank transaction datasets for identifying and preventing bank fraud. It also provides an evaluation and effectiveness of the ensemble of decision trees on the credit card dataset.
Chiral Solutions to Generalized Burgers and

We investigate generalizations of the Burgers and Burgers-Huxley equations. The investigations we offer focus attention mainly on presenting explict analytical solutions by means of relating these generalized equations to relativistic 1 + 1 dimensional systems of scalar fields where topological solutions are known to play a role. Emphasis is given on chiral solutions, that is, on the possibility of finding solutions that travel with velocities determined in terms of the parameters that identify the generalized equation, with a definite sign.
Ca2+-Activated K+ Channels Underlying the Impaired Acetylcholine-Induced Vasodilation in 2K-1C Hypertensive Rats

We tested the hypothesis that an abnormal function of K+ channels in vascular smooth muscle cells plays a key role in the impaired acetylcholine (ACh) vasodilation in aortas from two kidney-one clip (2K-1C) hypertensive rats and further investigated the K+ channel subtype involved in this altered response. ACh-induced endothelium-dependent relaxation was assessed in aortic rings from 2K-1C and normotensive two kidney (2K) rats. Glibenclamide, an ATP-sensitive K+ channel blocker, did not inhibit ACh-induced relaxation in aortic rings from 2K or 2K-1C rats. The voltage-dependent K+ channels inhibitor 4-aminopyridine attenuated ACh-induced relaxation in both groups. Charybdotoxin and iberiotoxin, blockers of Ca2+-sensitive (KCa) and large-conductance KCa (BKCa) channels, respectively, reduced ACh-induced relaxation in aortic rings from 2K rats without affecting this response in those from 2K-1C rats, abolishing the differences between groups. ACh-induced relaxation in vessels from both 2K and 2K-1C rats was unaffected by apamin, a small-conductance KCa blocker. NS1619 [1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one], an activator of KCa, induced a smaller vasodilation in endothelium-denuded aortic rings from 2K-1C rats compared with those from 2K rats. Iberiotoxin reduced sodium nitroprusside-induced relaxation in endothelium-denuded aortic rings from 2K without affecting this response in those from 2K-1C rats. The inhibition of Na+,K+-ATPase with ouabain had no effects on ACh-induced relaxation in aortic rings from 2K-1C or 2K rats. These data indicate that a deficient functional activity of BKCa channels plays a key role in the impaired ACh vasodilation in aortas from 2K-1C rats.
P53 germline mutations in childhood cancers and cancer risk for carrier individuals

The family history of cancer in children treated for a solid malignant tumour in the Paediatric Oncology Department at Institute Gustave-Roussy, has been investigated. In order to determine the role of germline p53 mutations in genetic predisposition to childhood cancer, germline p53 mutations were sought in individuals with at least one relative (first- or second-degree relative or first cousin) affected by any cancer before 46 years of age, or affected by multiple cancers. Screening for germline p53 mutation was possible in 268 index cases among individuals fulfilling selection criteria. Seventeen (6.3%) mutations were identified, of which 13 were inherited and four were de novo. Using maximum likelihood methods that incorporate retrospective family data and correct for ascertainment bias, the lifetime risk of cancer for mutation carriers was estimated to be 73% for males and nearly 100% for females with a high risk of breast cancer accounting for the difference. The risk of cancer associated with such mutations is very high and no evidence of low penetrance mutation was found. These mutations are frequently inherited but de novo mutations are not rare.
Licensed under Creative Commons Attribution Cc by a Link-based Cluster Ensemble Approach for Improved Gene Expression Data Analysis

It is difficult from possibilities to select a most suitable effective way of clustering algorithm and its dataset, for a defined set of gene expression data, because we have a huge number of ways and huge number of gene expressions. At present many researchers prefer to use hierarchical clustering in different forms, this is no more totally optimal. Cluster ensemble research can solve this type of problem by automatically merging multiple data partitions from a wide range of different clusterings of any dimensions to improve both the quality and robustness of the clustering result. But we have many existing ensemble approaches using an association matrix to condense sample-cluster and co-occurrence statistics, and relations within the ensemble are encapsulated only at raw level, while the existing among clusters are totally discriminated. Finding these missing associations can greatly expand the capability of those ensemble methodologies for microarray data clustering. We propose general K-means cluster ensemble approach for the clustering of general categorical data into required number of partitions.
26.5 Adaptive clocking in the POWER9™ processor for voltage droop protection

Increasing transistor counts in modern processors can create instantaneous changes in current, driving nanosecond-speed supply voltage (VDD) droops that require extra guardband for correct product operation. The POWER9 processor uses an adaptive clock strategy to reduce timing margin needed during power supply droop events by embedding analog voltage-droop monitors (VDMs) that direct a digital phase-locked loop (DPLL) to immediately reduce clock frequency in response.
A hexa-band coupled-fed PIFA antenna for 4G mobile phone application

A coupled-fed microstrip antenna for 4G mobile system is presented. The PIFA antenna operates at 704-960 MHz and 1710-2170 to cover frequency bands of LTE 700/850/900/1800/1900/2100(Tx/Rx). An L-shaped coupled-fed structure, an inductor and a shorting line to ground are compactly designed together to create dual resonances at both low and high bands to achieve wide bandwidth and better impedance matching. The overall dimension of mobile system is 58×119×1.2mm3 and the antenna size occupies area of 58×16mm2.
Revisiting the 'Cotton Problem': A Comparative Analysis of Cotton Reforms in Sub-Saharan Africa

The cotton sector has been among the most regulated in sub-Saharan Africa (SSA), and still largely is in West and Central Africa (WCA), despite repeated reform recommendations by international donors. On the other hand, orthodox reforms in East and Southern Africa (ESA) have not always yielded the expected results. This paper uses a stylized contracting model to investigate the link between market structure and equity and efficiency in SSA cotton sectors; explain the outcomes of reforms in ESA; and analyze the potential consequences of reforms in WCA. We illustrate our arguments with empirical observations on cotton sector performance. (This abstract was borrowed from another version of this item.)
The SurA periplasmic PPIase lacking its parvulin domains functions in vivo and has chaperone activity

The Escherichia coli periplasmic peptidyl‐prolyl isomerase (PPIase) SurA is involved in the maturation of outer membrane porins. SurA consists of a substantial N‐terminal region, two iterative parvulin‐like domains and a C‐terminal tail. Here we show that a variant of SurA lacking both parvulin‐like domains exhibits a PPIase‐independent chaperone‐like activity in vitro and almost completely complements the in vivo function of intact SurA. SurA interacts preferentially (>50‐fold) with in vitro synthesized porins over other similarly sized proteins, leading us to suggest that the chaperone‐like function of SurA preferentially facilitates maturation of outer membrane proteins.
Reurbanisation in a post-socialist city: Spatial differentiation of the population in the Kraków area (Poland)

A process of reurbanisation associated with the resurgence of inner-city housing has been observed in Western Europe since the 1980s. Nowadays this trend is not only seen in large urban areas but also in the medium-sized towns and cities of Eastern Europe. However, there is still a lack of empirical research on the spatial variation of the population change within such cities. This paper explores the process of reurbanisation in the city cores and its underlying dynamics against demographic changes, using the city of Kraków (Poland) as an example.
Quality of Life and Employment Status of Workers With Western Red Cedar Asthma

Objective: The impact of current employment status and other factors on quality of life was evaluated for workers diagnosed with western red cedar asthma in British Columbia, Canada. Methods: Telephone interviews by questionnaire included the Short Form 36 (SF-36) and Marks Asthma quality-of-life instruments. Results: Of the 302 subjects contacted, 70.5% (n = 213) participated. Employment status was the most consistent predictor of quality-of-life domains, with highest scores for employed subjects, particularly those who were no longer exposed to red cedar. Subjects who had quit work because of their asthma had worse scores, particularly for vitality and general health perceptions. Other factors independently associated with specific aspects of poor quality of life were having asthma-like symptoms, taking medication, and not being married. Conclusions: Continued employment was associated with better quality of life for workers with western red cedar asthma.
Effect and Feasibility of Controlled Rewarming After Moderate Hypothermia in Stroke Patients With Malignant Infarction of the Middle Cerebral Artery

Background and Purpose— Moderate hypothermia has been found to reduce intracranial pressure (ICP) significantly in patients who have severe middle cerebral artery infarction. However, during passive rewarming, ICP continuously rises and some patients suffer transtentorial herniation. Methods— We investigated the question of whether slower rewarming leads to slower increase in ICP and slower decrease in cerebral perfusion pressure (CPP). Furthermore, we studied feasibility of slow, controlled rewarming. ICP, CPP, and core body temperature were monitored continuously. Achievement of rewarming protocol was assessed by hit rate of temperature target intervals. Side effects of hypothermia were assessed. Results— Rates of change of both ICP and CPP were correlated significantly with increase in temperature (ICP r =0.62, P =0.002; CPP r =−0.50, P =0.017). In feasibility analysis of 13 controlled rewarmed patients, hit rate of temperature target intervals was 63% (median; range 48% to 81%); hit rate within the target interval or below was 79% (median; range 62% to 94%). Conclusions— Slow, controlled rewarming is feasible and may be used for ICP and CPP control after moderate hypothermia for space-occupying infarction.
Pulsing blue light through closed eyelids: effects on acute melatonin suppression and phase shifting of dim light melatonin onset

Circadian rhythm disturbances parallel the increased prevalence of sleep disorders in older adults. Light therapies that specifically target regulation of the circadian system in principle could be used to treat sleep disorders in this population. Current recommendations for light treatment require the patients to sit in front of a bright light box for at least 1 hour daily, perhaps limiting their willingness to comply. Light applied through closed eyelids during sleep might not only be efficacious for changing circadian phase but also lead to better compliance because patients would receive light treatment while sleeping. Reported here are the results of two studies investigating the impact of a train of 480 nm (blue) light pulses presented to the retina through closed eyelids on melatonin suppression (laboratory study) and on delaying circadian phase (field study). Both studies employed a sleep mask that provided narrowband blue light pulses of 2-second duration every 30 seconds from arrays of light-emitting diodes. The results of the laboratory study demonstrated that the blue light pulses significantly suppressed melatonin by an amount similar to that previously shown in the same protocol at half the frequency (ie, one 2-second pulse every minute for 1 hour). The results of the field study demonstrated that blue light pulses given early in the sleep episode significantly delayed circadian phase in older adults; these results are the first to demonstrate the efficacy and practicality of light treatment by a sleep mask aimed at adjusting circadian phase in a home setting.
Antitumoral, mutagenic and (anti)estrogenic activities of tingenone and pristimerin

Cancer constitutes the second main mortality cause in the world, after cardiovascular diseases. In spite of the progresses in the chemotherapeutics treatments, many patients fail chemotherapy, mainly because of side effects or multi-drugs resistance, proving the need and importance of the research for new molecules with anticancer activity, more effective and with smaller adverse effects. Various compounds derived from plant secondary metabolites are commonly used in the chemotherapy against cancer and the natural products play an important role in the research for new molecules. Among several molecules of natural origin evaluated by MTT assay in murine tumor cell lines [breast (LM3) and lung (LP07)] the quinona-methide triterpenes tingenone and pristimerin showed marked cytotoxic activity presenting IC50 around 2 and 5 µM respectively. The structure-activity relationship suggests that rings A and B containing an α, s-unsaturated carbonyl group are essential for the observed cytotoxic activity. The interaction between these positions and acetylcisteyne residues suggests a probable mechanism of action. The in vitro mutagenic activity was also evaluated by the Salmonella microsome assay (Ames test) for pristimerin and tingenone with and without metabolic activation (S9) in the strains TA98, TA97a, TA100 and TA102, none of which showed mutagenic potential in any strains. Estrogenic and anti-estrogenic activities were also studied by the e-screen assay in MCF-7 cells with negative results. The present data point to the importance of pristimerin and tingenone as representative of an emerging class of potential anticancer chemicals.
EMI Prediction of Power Converters using Switching Waveform Analysis

The fast switching semiconductors of a power converter cause conducted emissions. The variation of the switching behavior shows the influence of these conducted emissions of the converter. By an analysis of several measurements it is possible to determine the transfer behavior of the system. By using these parameters considering the spectral analysis of the switching waveforms it is possible to predict converter EMI. This paper shows the influence of the switching waveforms of semiconductors on conducted emissions in simulation and measurement.
Maximum-entropy moment-closure for stochastic systems on networks

Moment-closure methods are popular tools for simplifying the mathematical analysis of stochastic models defined on networks, in which high dimensional joint distributions are approximated (often by some heuristic argument) as functions of lower dimensional distributions. Whilst undoubtedly useful, several such methods suffer from issues of non-uniqueness and inconsistency. These problems are solved by an approach based on the maximization of entropy, which is motivated, derived and implemented in this paper. A series of numerical experiments are also presented, detailing the application of the method to the susceptible–infected–recovered model of epidemics, as well as cautionary examples showing the sensitivity of moment-closure techniques in general.
Permutations in a finite field

(1) ax + f, xQ-2 (at: EGF(q), a # 0). For q = 5, this was proved to be true by Betti; for q =7 the corresponding result was verified by Dickson [1, p. 119]. In this note we show very simply that this result holds for all q. Since the totality of permutation polynomials evidently furnishes a representation of the symmetric group on q letters, it will suffice to show that every transposition (Ga) can be generated by means of the special polynomials (1); here a denotes a fixed nonzero number CGF(q). We consider the following polynomial