Miracle-dz/UniFAR-FTUs huggingface dataset:
Long‐Term Complications in Patients With Hypoparathyroidism Evaluated by Biochemical Findings: A Case‐Control Study

Hypoparathyroidism (HypoPT) is associated with an increased risk of various complications, but only few data are available on risk factors. Using a case‐control design, we assessed associations between biochemical findings and risk of different complications within a subpopulation of our previously identified Danish patients. We retrieved all biochemical data available on 431 (81% women) patients from the Central Region of Denmark, covering approximately 20% of the Danish population. Average age of patients was 41 years at time of diagnosis. Most patients (88%) had HypoPT due to surgery, mainly due to atoxic goiter and more than 95% were on treatment with calcium supplements and activated vitamin D. On average, time‐weighted (tw) plasma levels of ionized calcium (Ca2+tw) was 1.17 mmol/L (interquartile range [IQR], 1.14 to 1.21 mmol/L) and the calcium‐phosphate (CaxPtw) product was 2.80 mmol2/L2 (IQR, 2.51 to 3.03 mmol2/L2). High phosphatetw levels were associated with increased mortality and risk of any infections, including infections in the upper airways. A high CaxPtw product was associated with an increased mortality and risk of renal disease. Compared to levels around the lower part of the reference interval, lower Ca2+tw levels were associated with an increased risk of cardiovascular diseases. Mortality and risk of infections, cardiovascular diseases, and renal diseases increased with number of episodes of hypercalcemia and with increased disease duration. Treatment with a relatively high dose of active vitamin D was associated with a decreased mortality and risk of renal diseases and infections. In conclusion, risk of complications in HypoPT is closely associated with disturbances in calcium‐phosphate homeostasis. © 2018 American Society for Bone and Mineral Research.
Various patterns of disrupted daily rest–activity rhythmicity associated with diabetes

Disruptions to sleep and circadian rhythms have now been recognized as common comorbidities in patients with medical illnesses. We aimed to determine if the diurnal rhythms for rest and activity were disrupted in parallel with the development of diabetic complications. Ninety outpatients in our diabetes clinic who had a body mass index <25 kg m2 wore an actigraph for 7 consecutive days (42 men; mean age 68.7 ± 8.2 years). Patients with neuropsychiatric diseases, liver cirrhosis, renal failure, chronic obstructive pulmonary disease or blindness, or those who performed shiftwork were excluded. We grouped the actigraph recordings into 1‐h periods and counted the number of minutes that showed activity. Stepwise regression analysis showed an association between a diabetic clinical background and measurements of circadian rhythms such as daytime activity, night‐time activity, phase, interdaily stability, intradaily variability and relative amplitude. Higher age, body mass index, total cholesterol levels and insulin usage were associated with lower daytime activity and higher intradaily variability, whereas higher haemoglobin A1c levels and the presence of neuropathy were associated with greater daytime activity. The presence of proliferative retinopathy and increased levels of microalbuminuria were associated with higher intradaily variability and lower interdaily stability and amplitude. The presence of cardiovascular disease was associated with advanced phase, whereas painful neuropathy was associated with delayed phase. Our study demonstrated that different diabetic complications were associated independently with a variety of alterations in the circadian rest and activity rhythms. Our findings have provided novel insights that may be helpful in developing interventions for sleep–wake disorders associated with diabetes.
Retinal ganglion cells in goldfish: a qualitative classification into four morphological types, and a quantitative study of the development of one of them

In this paper we describe the dendritic morphology of ganglion cells that have been retrogradely stained with HRP taken up by the cut optic nerve. This technique produces an extensive Golgi-like filling of the cells. From their appearance in the retinal whole-mount, they were classified as four types, according to the sizes of the soma and dendritic field, the thickness of the primary dendrites, and the density of the arbors. Each type was subdivided according to the level(s) of stratification of the dendrites within the inner and outer plexiform layer(s) to yield a total of 15 subtypes (four for three types, three for the other). The retina of the goldfish grows by a balloon-like expansion, and by the addition of new neurons, in annuli, at the margin. Therefore, a similar cell type may be examined at a variety of stages of development in the same retina, as well as in the retinae from fish of various ages. We have used a computer-assisted microscope to do so, quantitatively, for one large and easily identified subtype. In small fish (ca. 4 cm long), the number of dendritic branch points, the total dendritic length, and the dendritic field sizes of these cells are constant inside a central zone extending to 70–80% of the retinal radius. The magnitudes of all three numeric descriptors decrease closer to the margin. In large fish (ca. 14 cm long), the central zone extends to more than 90% of the retinal radius, and the same pattern holds. The area of the dendritic fields and the total dendritic lengths are both greater in the central zone of the large fish than in the small, but the number of branches is the same in both. This suggests that once a cell has achieved the “mature” number of dendritic branches, further growth is interstitial. A comparison of dendritic morphologies across the retina shows that the pattern of dendritic outgrowth in peripheral retina is initially directed parallel to the margin, and, later, toward the margin. This suggests that dendritic growth is impeded by the dendrites present in more central retina and proceeds preferentially where they are absent. Cells of the same age are at different distances from the optic disk in the small and large retinae. In some cases, they have quite different dendritic morphologies. This implies that dendritic development depends not only on the age and subtype of the cell, but on extrinsic factors as well. (ABSTRACT TRUNCATED AT 400 WORDS)
Building Instructional Leadership Capacity of School Leaders Through Technology Integration

Joy Dickerson Carey BUILDING INSTRUCTIONAL LEADERSHIP CAPACITY OF SCHOOL LEADERS THROUGH TECHNOLOGY INTEGRATION 2009/2010 James Coaxum, III, Ph.D. Educational Leadership Research suggested that the acquisition of technology instructional leadership skills develops principals‘ abilities to become agents of change. ―A firm foundation in technology knowledge, skills relative to the instructional process, and leadership and managerial skills in technology are required‖ (Geer, 2002, p. 57). It was critical for principals to enhance their technological communication skills, managerial applications, knowledge on information processing, and promote technology instruction methods in order to increase student learning (Daresh, 2006). The purpose of this action research project was to provide six school district principals with technology professional development, which enabled them to become effective instructional leaders for technology integration into the curriculum. My action research design utilized qualitative and quantitative data collection strategies, which were appropriate to effectively answer the research questions. The collection of qualitative research allowed me to triangulate participant observations, interviews, focus groups, and artifact collection to explore the research problem (Yin, 1994). Quantitative data collection employed formative and summative surveys. I examined my espoused authentic leadership theory within each cycle of my action research. The influence of my leadership practices was realized through the analysis of the Learning Practices Inventory (LPI) (Kouze & Posner, 2002), participant‘s comments during focus groups, and their reflections within interviews and surveys. The triangulated analysis of the focus groups, interviews, surveys, and field notes revealed that the principals' perceived that their technology training provided them with the competencies, focus, and confidence to implement technology integration leadership through effective planning, evaluation, and enrollment of all stakeholders in the change process. (Fullan, 2007; Kotter 1997; Schwahn & Spady, 1998; Senge, 1990).
Taxes and Investment in Annuities

dramatically with aggregate annuity purchases reaching $159.3 billion in 1995. While many annuities are job-related, by 1994 individual annuity purchases outside of job-related retirement plans had grown to $51 billion. This paper uses state-level data on annuity premiums for 1984-93 to explore the expansion of the annuity market and how taxes have affected this market. Annuities are tax-advantaged investments because income taxes are deferred. Higher tax rates can affect annuity purchases by affecting the overall level of saving, by inducing a switch towards tax-advantaged investments, or by encouraging investors to buy annuities at younger ages to increase the value of tax deferral. Both state-level variation in income tax rates and time-series variation in federal tax policy help identify differences in tax incentives to buy annuities. In our benchmark econometric specification using year and state fixed effects, a one percentage point increase in the marginal tax rate increases per capita individual annuity purchases by 4.3 percent. However, this result is somewhat sensitive to the econometric specification. Estimates controlling for year fixed effects but not state fixed effects suggest the overall effect of taxes on annuity purchases is negative and statistically significant. Furthermore, the effect of tax rates on annuity purchases depends on the age composition within the state. The effect of tax rates on annuity purchases increases with the fraction of the population between the ages 50 and 59.
Relationship between follicular fluid hormone levels, embryo quality, and maternal age duringin vitro fertilization after the short or long protocol with a gonadotropin releasing hormone agonist

PurposeTo examine the relationship between embryo quality and follicular fluid hormonal level in short and long protocol gonadotrophin releasing hormone agonist treatment cycles.MethodsA total of 90 patients had non-polycystic ovary syndrome (non-PCOS) and 10 had PCOS. A total of 100 subjects underwentin vitro fertilization (IVF). Thirty-six subjects underwent conventional IVF and 64 subjects underwent intra-cytoplasmic sperm injection (ICSI). The dominant follicles were initially retrieved and a hormonal assay was done. A total of 32 patients underwent a short protocol and 66 patients were treated with the long protocol. Estradiol (E2), progester-one (P4), total testosterone (TIE) and androstenedione (ASG) levels in follicular fluid (FF) were compared in the two treatment groups (short and long protocol), in regard to maternal age and oocyte/embryo quality.ResultsThe retrieval FF volume was not significantly different between the PCOS and non-PCOS patients; however, P4 was significantly lower with PCOS (P < 0.01). Analysis of four different hormone levels was not significantly different between the short and long protocol groups. No significant relationship was found between four hormone levels in regard to oocyte morphology and embryo quality. The levels of P4 of younger women was significantly lower than that of older women; furthermore, a significantly higher TTE and ASG were found in the younger women. Progesterone was found to statistically significantly increase with FF volume.ConclusionFollicular fluid P4 from the younger group was significantly lower, and TTE and ASG was significantly higher when compared to the older group. Analysis of four different hormone levels revealed no significant difference between the short and long protocol groups. No significant relationship was found between four hormone levels, oocyte morphology, and embryo quality.
Spray Dried, Pasteurised Bovine Colostrum Protects Against Gut Dysfunction and Inflammation in Preterm Pigs

Objective: Feeding bovine colostrum (BC) improves gut maturation and function and protects against necrotizing enterocolitis, relative to formula in newborn preterm pigs. Before BC can be used for preterm infants, it is important to test if the milk processing, required to reduce bacterial load and increase shelf life, may affect bioactivity and efficacy of a BC product. Methods: We investigated if spray dried, pasteurised BC had protective effects on gut function in preterm pigs, relative to formula. After a 2-day total parenteral nutrition period, preterm pigs were fed formula for a few hours (to induce a proinflammatory state) followed by 2 days of formula (FORM, n = 14), BC (colostrum [COLOS], n = 14), spray-dried BC (POW, n = 8), or pasteurised, spray-dried BC (POWPAS, n = 9). Results: Spray drying and pasteurisation of BC decreased the concentration of transforming growth factor-&bgr;1, -&bgr;2 and increased protein aggregation. All of the 3 BC groups had reduced necrotizing enterocolitis severity, small intestinal levels of IL-1&bgr;, -8, and colonic lactic acid levels, and increased intestinal villus height, hexose absorption, and digestive enzyme activities, relative to the FORM group (all P < 0.05). All of the 3 BC diets stimulated epithelial cell migration in a wound-healing model with IEC-6 cells. Conclusions: Spray drying and pasteurisation affect BC proteins, but do not reduce the trophic and anti-inflammatory effects of BC on the immature intestine. It remains to be studied if BC products will benefit preterm infants just after birth when human milk is often not available.
Is Environmental Policy a Secondary Trade Barrier? An Empirical Analysis

Should international trade agreements be extended to include negotiations over environmental policy? The answer depends on whether countries distort levels of environmental regulations as a secondary means of providing protection to domestic industries; our results suggest that they do. Previous studies of this relationship have treated the level of environmental regulation as exogenous, and found a negligible correlation between environmental regulation and trade flows. In contrast, we find that, when the level of environmental regulation is modeled as an endogenous variable, its estimated effect on trade flows is significantly higher than previously reported.
Andalucia (n. gen.)—the Deepest Branch Within Jakobids (Jakobida; Excavata), Based on Morphological and Molecular Study of a New Flagellate from Soil

ABSTRACT. A new heterotrophic flagellate (Andalucia godoyi n. gen. n. sp.) is described from soil. Earlier preliminary 18S rRNA analyses had indicated a relationship with the phylogenetically difficult‐to‐place jakobid Jakoba incarcerata. Andalucia godoyi is a small (3–5 μm) biflagellated cell with a ventral feeding groove. It has tubular mitochondrial cristae. There are two major microtubular roots (R1, R2) and a singlet root associated with basal body 1 (posterior). The microtubular root R1 is associated with non‐microtubular fibres “I,”“B,” and “A,” and divides in two parts, while R2 is associated with a “C” fibre. These structures support the anterior portion of the groove. Several features of A. godoyi are characteristic of jakobids: (i) there is a single dorsal vane on flagellum 2; (ii) the C fibre has the jakobid multilaminate substructure; (iii) the dorsal fan of microtubules originates in very close association with basal body 2; and (iv) there is no “R4” microtubular root associated with basal body 2. Morphological analyses incorporating the A. godoyi data strongly support the monophyly of all jakobids. Our 18S rRNA phylogenies place A. godoyi and J. incarcerata as a strong clade, which falls separately from other jakobids. Statistical tests do not reject jakobid monophyly, but a specific relationship between Jakoba libera and J. incarcerata and/or A. godoyi is rejected. Therefore, we have established a new genus Andalucia n. gen. with the type species Andalucia godoyi n. sp. , and transfer Jakoba incarcerata to Andalucia as Andalucia incarcerata n. comb.
2,3′,4,4′,5-Pentachlorobiphenyl impairs insulin-induced NO production partly through excessive ROS production in endothelial cells

Abstract Polychlorinated biphenyls (PCBs) have been reported to be associated with increased risk to hypertension, atherosclerosis, cardiovascular disease, etc. 2,3′,4,4′,5-Pentachlorobiphenyl, known as PCB-118, is a member of coplanar PCBs which renders their structure similar to polychlorinated dibenzo-p-dioxins (PCDDs) and has dioxin-like activity. In our current study, we investigated the effect of PCB-118 exposure on nitric oxide (NO) production and the underlying mechanisms in vitro. Exposure of PCB-118 impaired insulin-induced NO production and endothelial nitric oxide synthase (eNOS) activity in human umbilical vein endothelial cells (HUVECs) with no significant effect on cell viability. Furthermore, PCB-118 treatment induced oxidative stress. In addition, scavenging of reactive oxygen species (ROS) by 10 μM N-acetyl-l-cysteine (NAC) partly rescued impaired insulin-induced eNOS activities and NO productions induced by PCB-118 in HUVECs. Taken together, these results indicate that PCB-118 mediates lower eNOS activity and impairs insulin-induced NO production partly through excessive ROS production in endothelial cells.
DNA polymerase I is required for premeiotic DNA replication and sporulation but not for X-ray repair in Saccharomyces cerevisiae

We have used a set of seven temperature-sensitive mutants in the DNA polymerase I gene of Saccharomyces cerevisiae to investigate the role of DNA polymerase I in various aspects of DNA synthesis in vivo. Previously, we showed that DNA polymerase I is required for mitotic DNA replication. Here we extend our studies to several stages of meiosis and repair of X-ray-induced damage. We find that sporulation is blocked in all of the DNA polymerase temperature-sensitive mutants and that premeiotic DNA replication does not occur. Commitment to meiotic recombination is only 2% of wild-type levels. Thus, DNA polymerase I is essential for these steps. However, repair of X-ray-induced single-strand breaks is not defective in the DNA polymerase temperature-sensitive mutants, and DNA polymerase I is therefore not essential for repair of such lesions. These results suggest that DNA polymerase II or III or both, the two other nuclear yeast DNA polymerases for which roles have not yet been established, carry out repair in the absence of DNA polymerase I, but that DNA polymerase II and III cannot compensate for loss of DNA polymerase I in meiotic replication and recombination. These results do not, however, rule out essential roles for DNA polymerase II or III or both in addition to that for DNA polymerase I.
Weather impacts expressed sentiment

We conduct the largest ever investigation into the relationship between meteorological conditions and the sentiment of human expressions. To do this, we employ over three and a half billion social media posts from tens of millions of individuals from both Facebook and Twitter between 2009 and 2016. We find that cold temperatures, hot temperatures, precipitation, narrower daily temperature ranges, humidity, and cloud cover are all associated with worsened expressions of sentiment, even when excluding weather-related posts. We compare the magnitude of our estimates with the effect sizes associated with notable historical events occurring within our data.
Depression and potential risk factors among the elderly with Type 2 Diabetes Mellitus in Kedah, Malaysia.

OBJECTIVE Elderly with diabetes has been found to have a higher chance of depression. Therefore, the aim of this study is to determine the prevalence of depression and its associated factors among elderly with Type 2 Diabetes Mellitus in Kedah. METHODS A cross-sectional study was conducted at the Klinik Kesihatan Bandar, Sungai Petani, Kedah. The inclusion criteria were patients aged ≥60 years with Type 2 Diabetes Mellitus. Those with cognitive impairment, presence of organic brain syndrome, presence of severe mental disorder and patients who are either deaf or mute were excluded. The Malay version of Geriatric Depression Scale (M-GDS-14) was used to assess the depressive symptoms. The data was analysed using descriptive statistic and multiple logistic regression. RESULTS A total of 511 patients participated in the study. The mean age of the respondents is 64.5 (Standard Deviation 7.0) years old. There were slightly more males (53.8%). Majority were Malay (63.0%), married (76.9%) and has a household income of less than RM1000 (67.5%). The prevalence of depression was 32.1%. The number of elderly people living with their children (Adjusted Odds Ratio, aOR0.20, 95%CI: 0.07, 0.55), elderly living with spouse, children, in law and grandchildren (aOR2.95, 95%CI: 1.18, 7.37), diabetic complication (aOR4.68, 95%CI: 2.63, 8.35) and HbA1c (aOR1.23, 95%CI: 1.09, 1.39) are significantly associated with depression. CONCLUSION The level of depression was found to be high. Factors contributing to the significantly high level of depression are found to be associated with living arrangements, diabetic complication and HbA1c were significantly associated with depression.
Sleeping in a Brave New World: Opportunities for Improving Learning and Clinical Outcomes Through Targeted Memory Reactivation

Neuroscientific insights into learning and memory have mostly concerned input and output, but intervening processing during the time between acquisition and retrieval is also critical. Indeed, intervening memory reactivation may regulate memory longevity, and a growing body of evidence implicates sleep in changing memory storage. For example, subtle auditory stimulation can be used experimentally to selectively encourage memory reactivation during sleep, which thereby improves learning. Much remains to be elucidated about how learning depends on sleep. Nevertheless, this methodology for modifying memory storage during sleep offers new opportunities for reinforcing learning to enhance clinical outcomes in conjunction with therapies engaged during waking. A variety of such possibilities must now be carefully investigated. Likewise, brain rhythms can be entrained to enhance sleep functions, facilitating further progress in understanding the neurophysiological basis of memory processing during sleep. Ultimately, empirical evidence may reveal the extent to which the way we behave when awake is a function of what our brains do when we are asleep. Through such research efforts, an advanced understanding of memory and sleep may allow us to both make better use of our time asleep and take steps toward better health.
CBT and recovery from psychosis in the ISREP trial: mediating effects of hope and positive beliefs on activity.

OBJECTIVE Hope and positive self-concept have been highlighted as important components of recovery from psychosis. This study investigated the impact of a recovery-focused intervention on these dimensions, as well as their role as mediators of functional outcome. METHODS Seventy-seven participants in recovery from psychosis were recruited into a randomized controlled trial of social recovery-focused cognitive-behavioral therapy (SRCBT). The primary outcome was hours spent weekly in structured activity. Hopelessness and beliefs about self and others were also assessed. RESULTS SRCBT had a significant effect on improving positive beliefs about self and others. A trend was noted suggesting a main effect of SRCBT on reducing hopelessness among individuals with nonaffective psychosis. Increases in positive beliefs about self were found to mediate improvements in activity in the SRCBT group. CONCLUSIONS Fostering hope and positive self-concept should be central components of recovery-oriented services and interventions. Modifying these dimensions may have a positive impact on functional outcome.