Miracle-dz/UniFAR-FTUs huggingface dataset:
A noninvasive evaluation analysis of amniotic fluid embolism and disseminated intravascular coagulopathy

Objective. Amniotic fluid embolism (AFE) is a complication of pregnancy with a high mortality rate. The diagnosis of AFE is currently based on clinical findings, acute respiratory distress, cardiovascular collapse during labor and delivery, and immediate massive postpartum hemorrhaging. The serum biological markers are unreliable, and their detection requires a long time intervals for result. An early diagnosis is very important and prompts the clinical management of the condition. Study design and results. We present here a noninvasive method (time frequency, entropy) to analyze heart rate variability (HRV). 3D-Spectrogram and entropy were derived from the RR interval of two pregnant subjects with AFE and disseminated intravascular coagulation (DIC) survived after delivering normal babies admitted to the Taiwan Seventh-day Adventists Hospital, and the entropy values were compared with those of 105 healthy pregnant subjects in the same hospital. Conclusions. We show that these methods can be successfully applied to the diagnosis of AFE and predict the prognosis of DIC. We also show that CT scans can be applied to the diagnosis of pulmonary embolism, eliminating the need to pathology.
A New Density Evolution Approximation for LDPC and Multi-Edge Type LDPC Codes

This paper considers density evolution for low-density parity-check (LDPC) and multi-edge type LDPC (MET-LDPC) codes over the binary input additive white Gaussian noise channel. We first analyze three single-parameter Gaussian approximations for density evolution and discuss their accuracy under several conditions, namely, at low rates, with punctured and degree-one variable nodes. We observe that the assumption of symmetric Gaussian distribution for the density-evolution messages is not accurate in the early decoding iterations, particularly at low rates and with punctured variable nodes. Thus, single-parameter Gaussian approximation methods produce very poor results in these cases. Based on these observations, we then introduce a new density evolution approximation algorithm for LDPC and MET-LDPC codes. Our method is a combination of full density evolution and a single-parameter Gaussian approximation, where we assume a symmetric Gaussian distribution only after density-evolution messages closely follow a symmetric Gaussian distribution. Our method significantly improves the accuracy of the code threshold estimation. Additionally, the proposed method significantly reduces the computational time of evaluating the code threshold compared with full density evolution thereby making it more suitable for code design.
Distribution of substance P‐like immunoreactive neurons in the human medulla oblongata: Co‐localization with monoamine‐synthesizing neurons

The raphe nuclei also contained SP‐like immunoreactivity (up to 30%) while few monoamine‐synthesizing neurons in the lateral and dorsomedial medulla contained SP‐like immunoreactivity approximately 5% of presumed serotonin‐, noradrenaline‐, and adrenthe adult human. The majority of SP‐like immunoreactive neurons were found in four main regions: the lateral medulla, the dorsomedial medulla, the spinal trigeminal nucleus, and the raphe nuclei. The morphology of immunoreactive cells varied according to the region in which they were found. In contrast to previous studies, we found large numbers (90,000) of SP‐like immunoreactive neurons throughout the adult human medulla oblongata. The distribution of these SP‐like immunoreactive neurons appears to be significantly different from those described in the rat and cat.
Ontoterminology: How to unify terminology and ontology into a single paradigm

Terminology is assigned to play a more and more important role in the Information Society. The need for a computational representation of terminology for IT applications raises new challenges for terminology. Ontology appears to be one of the most suitable solutions for such an issue. But an ontology is not a terminology as well as a terminology is not an ontology. Terminology, especially for technical domains, relies on two different semiotic systems: the linguistic one, which is directly linked to the Language for Special Purposes and the conceptual system that describes the domain knowledge. These two systems must be both separated and linked. The new paradigm of ontoterminology, i.e. a terminology whose conceptual system is a formal ontology, emphasizes the difference between the linguistic and conceptual dimensions of terminology while unifying them. A double semantic triangle is introduced in order to link terms (signifiers) to concept names on a first hand and meanings (signified) to concepts on the other hand. Such an approach allows two kinds of definition to be introduced. The definition of terms written in natural language is considered as a linguistic explanation while the definition of concepts written in a formal language is viewed as a formal specification that allows operationalization of terminology.
The New Face of East–West Migration in Europe

In order to contextualise the papers in this special issue, this paper presents an overview and framework for understanding the importance of East–West migration in Europe associated with the EU enlargement process. The new patterns and forms of migration seen among East European migrants in the West—in terms of circular and temporary free movement, informal labour market incorporation, cultures of migration, transnational networks, and other phenomena documented in the following papers—illustrate the emergence of a new migration system in Europe. Textbook narratives, in terms of standard accounts of immigration, integration and citizenship based on models of post-colonial, guestworker and asylum migration, will need to be rethought. One particularly fertile source for this is the large body of theory and research developed in the study of Mexican–US migration, itself a part of a regional integration process of comparative relevance to the new European context. While the benefits of open migration from the East will likely triumph over populist political hostility, it is a system that may encourage an exploitative dual labour market for Eastern movers working in the West, as well as encouraging a more effective racial or ethnically-based closure to immigrants from South of the Mediterranean and further afield.
Neuronal activity in the lateral cerebellum of trained monkeys, related to visual stimuli or to eye movements.

1. The responses of neurones in the lateral cerebellar cortex to visual stimuli and to eye movements were recorded in rhesus monkeys trained to perform visually guided arm and eye movements in a tracking task. 2. Twenty‐two of 134 units recorded (16%) modulated their discharge in response to a bright Xenon flash. They were mainly located in the dorsal paraflocculus. Among those identified as Purkinje cells both simple spike and climbing fibre responses to the flash were seen. (72% of the units were related to arm movements; these were centred in the paramedian lobule, and have been described fully in Marple‐Horvat & Stein (1987). ) 3. The visual responsiveness of one of the units varied according to the phase of the monkey's task. Around the time that the target stepped, which was the monkey's cue to move, its sensitivity to other stimuli disappeared. 4. Only two neurones responded to the movements of the tracking target. These responses were conditional upon the monkey using visual signals to guide his movements; they did not respond to the target step if he moved before the target did. 5. Fourteen units (10%) located in crus I and II and lobulus simplex correlated strongly with the velocity of horizontal eye movements. Only one of these also responded to visual stimuli. 6. Thus most neurones were found to carry only visual, or eye movement, or limb movement information rather than combinations of these signals; they were located in different but overlapping regions of lateral cerebellar cortex. Visually responsive neurones are probably involved in planning the visual goal of movements, while eye and arm movement neurones probably help to create co‐ordinative structures for executing voluntary eye and arm movements.
Lipoprotein predictors of the severity of coronary artery disease in men and women.

In this study we examined the relationships between levels of several components of plasma lipoproteins and severity of coronary artery disease in 65 men and 42 women who underwent coronary arteriography for suspected coronary disease. Severity of coronary atherosclerosis was scored as the extent of disease seen at arteriography. Univariate analyses of the relationships between the plasma lipoprotein parameters and score for severity of atherosclerosis revealed a marked difference between men and women. In men, the score for severity of atherosclerosis was strongly related to the low-density lipoprotein (LDL) cholesterol and apolipoprotein B concentrations, whereas in women it was related to the triglyceride concentrations in plasma intermediate-density lipoprotein (IDL) and LDL and to the cholesterol and apolipoprotein B concentrations in IDL. The significance of these correlations was not negated by possible confounding factors such as alcohol intake, diabetes, and treatment with thiazides and beta-adrenergic blockers. Stepwise regression analyses of data adjusted for weight and age indicated that 22% of the variation in the score for severity of atherosclerosis could be accounted for by levels of LDL cholesterol in men. No other lipoprotein parameter could account for any further variation. In contrast, cholesterol did not account for any variation in the score for severity of atherosclerosis in women, whereas plasma triglyceride accounted for 16% of the observed variation in this group. No relationships were found between score for severity of atherosclerosis and high-density lipoprotein cholesterol or plasma apolipoprotein A-I concentrations in either group. (ABSTRACT TRUNCATED AT 250 WORDS)
The reliability and validity of the physical activity questions in the WHO health behaviour in schoolchildren (HBSC) survey: a population study

Objective—To assess the test-retest reliability and validity of the physical activity questions in the World Health Organisation health behaviour in schoolchildren (WHO HBSC) survey. Methods—In the validity study, the Multistage Fitness Test was administered to a random sample of year 8 (mean age 13.1 years; n = 1072) and year 10 (mean age 15.1 years; n = 954) high school students from New South Wales (Australia) during February/March 1997. The students completed the self report instruments on the same day. An independent sample of year 8 (n = 121) and year 10 (n = 105) students was used in the reliability study. The questionnaire was administered to the same students on two occasions, two weeks apart, and test-retest reliability was assessed. Students were classified as either active or inadequately active on their combined responses to the questionnaire items. Kappa and percentage agreement were assessed for the questionnaire items and for a two category summary measure. Results—All groups of students (boys and girls in year 8 and year 10) classified as active (regardless of the measure) had significantly higher aerobic fitness than students classified as inadequately active. As a result of highly skewed binomial distributions, values of kappa were much lower than percentage agreement for test-retest reliability of the summary measure. For year 8 boys and girls, percentage agreement was 67% and 70% respectively, and for year 10 boys and girls percentage agreement was 85% and 70% respectively. Conclusions—These brief self report questions on participation in vigorous intensity physical activity appear to have acceptable reliability and validity. These instruments need to be tested in other cultures to ensure that the findings are not specific to Australian students. Further refinement of the measures should be considered.
Electrochemical glucose biosensors.

First-generation glucose biosensors relied on the use of the natural oxygen cosubstrate and the production and detection of hydrogen peroxide and were much simpler, especially when miniaturized sensors are concerned. More sophisticated bioelectronic systems for enhancing the electrical response, based on patterned monolayer or multilayer assemblies and organized enzyme networks on solid electrodes, have been developed for contacting GOx with the electrode support. Electrochemical biosensors are well suited for satisfying the needs of personal (home) glucose testing, and the majority of personal blood glucose meters are based on disposable (screen-printed) enzyme electrode test strips, which are mass produced by the thick film (screen-printing) microfabrication technology. In the counter and an additional “baseline” working electrode, various membranes (mesh) are incorporated into the test strips along with surfactants, to provide a uniform sample coverage. Such devices offer considerable promise for obtaining the desired clinical information in a simpler, user-friendly, faster, and cheaper manner compared to traditional assays. Continuous ex-vivo monitoring of blood glucose was proposed in 1974 and the majority of glucose sensors used for in-vivo applications are based on the GOx-catalyzed oxidation of glucose by oxygen. The major factors that play a role in the development of clinically accurate in-vivo glucose sensors include issues related to biocompatibility, miniaturization, long-term stability of the enzyme and transducer, oxygen deficit, short stabilization times, in-vivo calibration, baseline drift, safety, and convenience.
Response-Predictive Gene Expression Profiling of Glioma Progenitor Cells In Vitro

Background High-grade gliomas are amongst the most deadly human tumors. Treatment results are disappointing. Still, in several trials around 20% of patients respond to therapy. To date, diagnostic strategies to identify patients that will profit from a specific therapy do not exist. Methods In this study, we used serum-free short-term treated in vitro cell cultures to predict treatment response in vitro. This approach allowed us (a) to enrich specimens for brain tumor initiating cells and (b) to confront cells with a therapeutic agent before expression profiling. Results As a proof of principle we analyzed gene expression in 18 short-term serum-free cultures of high-grade gliomas enhanced for brain tumor initiating cells (BTIC) before and after in vitro treatment with the tyrosine kinase inhibitor Sunitinib. Profiles from treated progenitor cells allowed to predict therapy-induced impairment of proliferation in vitro. Conclusion For the tyrosine kinase inhibitor Sunitinib used in this dataset, the approach revealed additional predictive information in comparison to the evaluation of classical signaling analysis.
Aerobic biodegradation of biphenyl and polychlorinated biphenyls by Arctic soil microorganisms

We examined the degradation of biphenyl and the commercial polychlorinated biphenyl (PCB) mixture Aroclor 1221 by indigenous Arctic soil microorganisms to assess both the response of the soil microflora to PCB pollution and the potential of the microflora for bioremediation. In soil slurries, Arctic soil microflora and temperate-soil microflora had similar potentials to mineralize [14C]biphenyl. Mineralization began sooner and was more extensive in slurries of PCB-contaminated Arctic soils than in slurries of uncontaminated Arctic soils. The maximum mineralization rates at 30 and 7 degrees C were typically 1.2 to 1.4 and 0.52 to 1.0 mg of biphenyl g of dry soil-1 day-1, respectively. Slurries of PCB-contaminated Arctic soils degraded Aroclor 1221 more extensively at 30 degrees C (71 to 76% removal) than at 7 degrees C (14 to 40% removal). We isolated from Arctic soils organisms that were capable of psychrotolerant (growing at 7 to 30 degrees C) or psychrophilic (growing at 7 to 15 degrees C) growth on biphenyl. Two psychrotolerant isolates extensively degraded Aroclor 1221 at 7 degrees C (54 to 60% removal). The soil microflora and psychrotolerant isolates degraded all mono-, most di-, and some trichlorobiphenyl congeners. The results suggest that PCB pollution selected for biphenyl-mineralizing microorganisms in Arctic soils. While low temperatures severely limited Aroclor 1221 removal in slurries of Arctic soils, results with pure cultures suggest that more effective PCB biodegradation is possible under appropriate conditions.
A Modified SRAM Based Low Power Memory Design

The present world aims in designing low power devices due to the rampant usage of portable battery powered gadgets. The proposed static random access memory (SRAM) design furnishes an approach towards curtailing the hold power dissipation. The design uses a tail transistor which aids in limiting the short circuit power dissipation by disrupting the direct connection between supply voltage and ground. This tail transistor also brings down the sub threshold current by providing stacking effect, which subsequently reduces hold power dissipation. A supply voltage of 0.8V is used which makes it eligible for low power applications. The designed SRAM cell has single ended write and read operations and is simulated using Cadence 45nm CMOS technology. Statistical and corner analysis is also performed for the proposed design for its robustness. The proposed SRAM cell has a hold power dissipation of 4.74154pW which is much less as compared to the standard 6T SRAM cell.
Enhanced activity of an insecticidal protein, trypsin modulating oostatic factor (TMOF), through conjugation with aliphatic polyethylene glycol.

BACKGROUND Trypsin modulating oostatic factor (TMOF), a decapeptide (Tyr-Asp-Pro-Ala-Pro(6)) isolated from the ovaries of the adult yellow fever mosquito, Aedes aegypti, regulates trypsin biosynthesis. TMOF per os is insecticidal to larval mosquitoes and a good model for the development of technologies to enhance protein insecticide activity by reduced catabolism and/or enhanced delivery to the target. RESULTS TFA-TMOF-K (TFA = trifluoro acetyl) allowed the specific conjugation of monodispersed, aliphatic polyethylene glycol (PEG) to the amino group of lysine-producing TMOF-K-methyl(ethyleneglycol)(7)-O-propionyl (TMOF-K-PEG(7) P). The addition of lysine to TMOF reduced its per os larval mosquitocidal activity relative to the parent TMOF, but conjugation of TMOF-K with methyl(ethyleneglycol)(7)-O-propionyl increased its toxicity 5.8- and 10.1-fold above that of TMOF and TMOF-K for Ae. aegypti. Enhanced insecticidal activity was also found for larval Ae. albopictus and for neonates of Heliothis virescens and Heliocoverpa zea. Only TMOF-K was found by MS/MS in the hemolymph for H. virescens fed on TMOF-K-PEG(7) P. No TMOF, TMOF-K or PEGylated TMOF-K was detected in the hemolymph after topical applications. CONCLUSIONS This research suggests that aliphatic PEG polymers can be used as a new method for increasing the activity of insecticidal proteins.
A Performance Measurement Paradigm for Integrating Strategy Formulation: A Review of Systems and Frameworks

Measuring organizational performance plays a very important part in translating corporate strategy into results. Various emerging (non-traditional) performance systems have recently been devised to aid firms in selecting and implementing measures. This paper discusses the strategy/measurement initiatives and compares ten emerging performance measurement systems with respect to a list of performance dimensions, the characteristics of performance measures, and the requirements of development process. Although these systems have constraints borne with their own application domains, they stand by themselves empirically and/or theoretically, and provide guidance about what to measure and how to design performance measures that could be linked to the corporate strategy and objectives of an organization. This paper concludes that there is a need to develop a paradigm for integrating strategy formulation and performance measurement in organizations.
Identification of a glycosylphosphatidylinositol anchor-modifying β1-3 galactosyltransferase in Trypanosoma brucei

Trypanosoma brucei is the causative agent of human African sleeping sickness and the cattle disease nagana. Trypanosoma brucei is dependent on glycoproteins for its survival and infectivity throughout its life cycle. Here we report the functional characterization of TbGT3, a glycosyltransferase expressed in the bloodstream and procyclic form of the parasite. Bloodstream and procyclic form TbGT3 conditional null mutants were created and both exhibited normal growth under permissive and nonpermissive conditions. Under nonpermissive conditions, the normal glycosylation of the major glycoprotein of bloodstream form T. brucei, the variant surface glycoprotein and the absence of major alterations in lectin binding to other glycoproteins suggested that the major function of TbGT3 occurs in the procyclic form of the parasite. Consistent with this, the major surface glycoprotein of the procyclic form, procyclin, exhibited a marked reduction in molecular weight due to changes in glycosylphosphatidylinositol (GPI) anchor side chains. Structural analysis of the mutant procyclin GPI anchors indicated that TbGT3 encodes a UDP-Gal: β-GlcNAc-GPI β1-3 Gal transferase. Despite the alterations in GPI anchor side chains, TbGT3 conditional null mutants remained infectious to tsetse flies under nonpermissive conditions.
Excessive daytime sleepiness works together with other sleep disorders in determining sleepiness-related events in shift workers.

BACKGROUND Shift-workers may experience sleep disturbances more frequently than day-workers. Interactions between obstructive sleep apnea (OSA), shift-work and other factors promoting sleepiness have never been studied. The present study was designed to assess the prevalence of excessive daytime sleepiness (EDS), high risk for OSA (HR) and insomnia in shift-workers and day-workers and to evaluate their mutual effects on the risk of home-to-work commuting car accidents or episodes of falling asleep during work. METHODS Workers (153 shift-workers, 85 day-workers) were evaluated for the presence of sleep disorders including HR and EDS. The relationships between sleepiness-related events, shift-work and sleep disorders were investigated by path analysis. RESULTS Forty-nine subjects had HR. EDS was more frequent in shift-workers than in day-workers (16.3% vs. 5.9%, P = 0.01) and in workers with HR (28.6% vs. 8.4%, P < 0.001) or insomnia (35.7% vs. 9.5%, P < 0.001). Path analysis support the evidence that EDS was directly linked to shift-work, HR and insomnia. Car accidents or falling asleep at work were directly associated with EDS and shift-work, and indirectly (via EDS) with HR and insomnia. CONCLUSIONS Development of EDS in shift-workers is not only due to work schedule, but also to the presence of sleep disorders. OSA and insomnia co-promote falling asleep during work and sleepiness-related car accidents.