Miracle-dz/UniFAR-FTUs huggingface dataset:
Laminin Interactions with Head and Neck Cancer Cells under Low Fluid Shear Conditions Lead to Integrin Activation and Binding*

Background: Clinically relevant tumor cell/lymph node interactions are likely initiated in the context of lymphodynamic flow. Results: β1 integrins mediate interaction with laminins under lymphodynamic shear stress, resulting in a discrete calcium signal. Conclusion: β1 integrins mediate tumor cell/lymph node interactions active under lymphodynamic flow. Significance: These novel interactions may drive growth and immunomodulation in this niche. Lymphatic metastasis of cancer cells involves movement from the primary tumor site to the lymph node, where the cells must be able to productively lodge and grow. It is there that tumor cells encounter cellular and non-cellular constituent elements that make up the lymph node parenchyma. Our work shows that head and neck squamous cell carcinoma (HNSCC) cell lines are able to bind to laminin, fibronectin, vitronectin, and hyaluronic acid, which are extracellular matrix elements within the lymph node parenchyma. HNSCC cell lines bound to laminin under lymphodynamic low shear stress (0.07 dynes/cm2), consistent with lymph flow via β1 integrins, including α2β1, α3β1, and α6β1. Binding occurred in the presence of shear stress and not in the absence of flow. Additionally, tumor cell binding to laminin under flow did result in calcium signaling. Our data indicate a novel role for β1 integrin-mediated binding of HNSCC cells to laminin under conditions of lymphodynamic flow that results in intracellular calcium signaling within the cancer cell.
Multimodal Discovering and Fusion for Semantics Multimedia Analysis

Semantics multimedia. Numerous researches have been focused on multi-modal analysis to detect multimedia semantics. However,there's still two fundamental issues which have not been adequately addressed. The first is how to choose the best independent modalities.The second is how are a set of modalities optimally fused to map to the high-level semantics. In this paper, statistical and machine learning techniques ISOMAP are applied to solve the two problems. Combining with support vector clustering, ISOMAP are first used to discover independent modalities from raw features. Then, Super Kernel method is applied to optimally fuse the individual modalities. Experiments show that the proposed method can learn multimedia semantics more efficiently than traditional methods.
Hierarchical transmission of picture signals on a MAN

Picture archiving and communication systems (PACS) have to handle a lot of moving or still images services with different resolution levels (HDTV-like, TV-like and lower resolutions), quality requirements (from acceptable visual quality to lossless) and different priorities. In this paper we present a new system for the integration of hierarchical images transmission in a broadband network based on the DQDB protocol (IEEE 802.6 standard). This system is based on the combination of two new tools. First we have designed a multiresolution/multiquality image coding scheme based on wavelet transforms. The main original feature of the algorithm is that it allows a multiresolution lossless access to images. A greater compression ration is possible at the price of graceful degradations. Secondly, we have implemented an improved priority mechanism in the DQDB protocol. The aim was that, in case of network overload, the emissions lose quality but are always maintained. A simulation of the implementation of such a system for the handling of the communications inside a hospital is also presented.
Minimizing Congestion in General Networks

A principle task in parallel and distributed systems is to reduce the communication load in the interconnection network, as this is usually the major bottleneck for the performance of distributed applications. We introduce a framework for solving online problems that aim to minimize the congestion (i.e. the maximum load of a network link) in general topology networks. We apply this framework to the problem of online routing of virtual circuits and to a dynamic data management problem. For both scenarios we achieve a competitive ratio of O(log/sup 3/ n) with respect to the congestion of the network links. Our online algorithm for the routing problem has the remarkable property that it is oblivious, i.e., the path chosen for a virtual circuit is independent of the current network load. Oblivious routing strategies can easily be implemented in distributed environments and have therefore been intensively studied for certain network topologies as e.g. meshes, tori and hypercubic networks. This is the first oblivious path selection algorithm that achieves a polylogarithmic competitive ratio in general networks.
Identifying Opinion Holders and Targets with Dependency Parser in Chinese News Texts

In this paper, we propose to identify opinion holders and targets with dependency parser in Chinese news texts, i.e. to identify opinion holders by means of reporting verbs and to identify opinion targets by considering both opinion holders and opinion-bearing words. The experiments with NTCIR-7 MOAT's Chinese test data show that our approach provides better performance than the baselines and most systems reported at NTCIR-7.
Incentivizing Signal and Energy Cooperation in Wireless Networks

We consider a two-hop wireless network where the source(s) in the network have the ability to wirelessly power the relay(s) who also have their own data to send to the destination. Considering the fact that each node in the network aims to maximize its own metric, we adopt a game theoretic approach that foresees offering relaying of the sources' data in exchange for energy provided to the relays, and simultaneously offering energy to the relays in exchange for their relaying services. We first study a Stackelberg competition with the single relay node as the leader, and investigate the impact of having multiple source nodes in the system. We next study the reciprocal Stackelberg game with the single source as the leader, and investigate the inter-relay competition with multiple relays. We find that in the Stackelberg games, the leader can improve its individual utility by influencing the follower's decision accordingly, even more so when there are multiple followers. We next formulate a noncooperative game between the source and the relay and show the existence of a unique Nash equilibrium by an appropriate pricing mechanism. The equilibrium maximizes the total utility of the network and allows the destination to choose how much data to receive from each node.
Observations of Accreting Pulsars

We summarize 5 years of continuous monitoring of accretion-powered pulsars with the Burst and Transient Source Experiment (BATSE) on the Compton Gamma Ray Observatory. Our 20-70 keV observations have determined or refined the orbital parameters of 13 binaries, discovered five new transient accreting pulsars, measured the pulsed flux history during outbursts of 12 transients (GRO J1744-28, 4U 0115+634, GRO J1750-27, GS 0834-430, 2S 1417-624, GRO J1948+32, EXO 2030+375, GRO J1008-57, A0535+26, GRO J2058+42, 4U 1145-619, and A1118-616), and also measured the accretion torque history during outbursts of six of those transients whose orbital parameters were also known. We have also continuously measured the pulsed flux and spin frequency for eight persistently accreting pulsars (Her X-1, Cen X-3, Vela X-1, OAO 1657-415, GX 301-2, 4U 1626-67, 4U 1538-52, and GX 1+4). Because of their continuity and uniformity over a long baseline, BATSE observations have provided new insights into the long-term behavior of accreting magnetic neutron stars. We have found that all accreting pulsars show stochastic variations in their spin frequencies and luminosities, including those displaying secular spin-up or spin-down on long timescales, which blurs the conventional distinction between disk-fed and wind-fed binaries. Pulsed flux and accretion torque are strongly correlated in outbursts of transient accreting pulsars but are uncorrelated, or even anticorrelated, in persistent sources. We describe daily folded pulse profiles, frequency, and flux measurements that are available through the Compton Observatory Science Support Center at NASA/Goddard Space Flight Center.
As Integrated Circuit Technologies Advance a Survey of Digital Design Reuse Design Environment for Soc Architecture Estimating and Budgeting Specification of System Components and Interfaces Verification and Validation Test Synthesis and Compilation Floor Planning References Industry Initiatives and

toward higher performance, greater densities, and increasing system complexity, CAD tools and design methodologies struggle to keep pace. Managing the formidable complexity of the design process is one of the main challenges to IC design. Disseminating design reuse is central to bringing the design effort’s complexity back to a manageable size. Effective reuse, though, takes more than just gathering predesigned components in a library. Reuse-oriented policies and strategies must permeate the entire design process, from the methodologies themselves to the final designs. In this article, we provide a brief overview of the state of the art in design reuse for digital systems. We also discuss the challenges posed to this discipline by the recent trend toward integrating processor cores in high-volume application-specific integrated circuits. Design reuse, particularly in the core-based system-on-chip (SOC) design era, is no longer a discipline in isolation. Reuse cannot be fully separated from simulation and verification, estimation, synthesis, or test. For example, the “Design Section” of the 1999 edition of the International Technology Roadmap for Semiconductors emphasized the need for synthesis technology to support the reuse of predesigned blocks with surrounding synthesized logic, thus facilitating intellectual property (IP) reuse.1 The need for new levels of abstraction to support efficient system-level early design-space exploration, synthesis, and simulation and verification is yet another example of a synergy increase across CAD areas. Early performance estimation is also important so that top-down design methodologies can correctly evaluate design decisions at high abstraction levels, such as at the system or architectural level. Without good estimation techniques, top-down design of deep submicron technologies may be impractical, and CAD tools developed for such design would be useless. The semiconductor and electronic-design-automation (EDA) industries must successfully leverage several decades of accumulated investment in hierarchical, topdown design methodologies. Finally, standardization—namely, for system descriptions and portable synthesis library formats—is yet another critical issue in SOC design.1 Figure 1 shows the main industry players for SOC, field-programmable design.
Wearables as Context for Guiard-abiding Bimanual Touch

We explore the contextual details afforded by wearable devices to support multi-user, direct-touch interaction on electronic whiteboards in a way that-unlike previous work-can be fully consistent with natural bimanual-asymmetric interaction as set forth by Guiard. Our work offers the following key observation. While Guiard's framework has been widely applied in HCI, for bimanual interfaces where each hand interacts via direct touch, subtle limitations of multi-touch technologies as well as limitations in conception and design-mean that the resulting interfaces often cannot fully adhere to Guiard's principles even if they want to. The interactions are fundamentally ambiguous because the system does not know which hand, left or right, contributes each touch. But by integrating additional context from wearable devices, our system can identify which user is touching, as well as distinguish what hand they use to do so. This enables our prototypes to respect lateral preference the assignment of natural roles to each hand as advocated by Guiard in a way that has not been articulated before.
IMPORTANCE OF MINERALS ON REPRODUCTION IN DAIRY CATTLE

Cow requirements for minerals are influenced by several factors including age, stage of pregnancy and stage of lactation. Trace mineral absorption and use performs an essential role in dairy cow reproduction and hoof health. The trace minerals play critical roles in the proper functioning of enzymes, hormones and cells. Deficiencies can, and often do, result in less-than-optimal performance and lost opportunity cost.
A Novel NIRS Index to Evaluate Brain Activity in Prefrontal Regions While Listening to First and Second Languages for Long Time Periods

Near-infrared spectroscopy (NIRS) has been widely used as a non-invasive method to measure brain activity, but it is corrupted by baseline drift noise. Here we present a method to measure regional cerebral blood flow as a derivative of NIRS output. We investigate whether, when listening to languages, blood flow can reasonably localize and represent regional brain activity or not. The prefrontal blood flow distribution pattern when advanced second-language listeners listened to a second language (L2) was most similar to that when listening to their first language (L1) among the patterns of mean and standard deviation. In experiments with 25 healthy subjects, the maximum blood flow was localized to the left BA46 of advanced listeners. The blood flow presented is robust to baseline drift and stably localizes regional brain activity. Keywords—NIRS, oxy-hemoglobin, baseline drift, blood flow, working memory, BA46, first language, second language.
Neural mechanisms mediating degrees of strategic uncertainty

Abstract In social interactions, strategic uncertainty arises when the outcome of one’s choice depends on the choices of others. An important question is whether strategic uncertainty can be resolved by assessing subjective probabilities to the counterparts’ behavior, as if playing against nature, and thus transforming the strategic interaction into a risky (individual) situation. By means of functional magnetic resonance imaging with human participants we tested the hypothesis that choices under strategic uncertainty are supported by the neural circuits mediating choices under individual risk and deliberation in social settings (i.e. strategic thinking). Participants were confronted with risky lotteries and two types of coordination games requiring different degrees of strategic thinking of the kind ‘I think that you think that I think etc.’ We found that the brain network mediating risk during lotteries (anterior insula, dorsomedial prefrontal cortex and parietal cortex) is also engaged in the processing of strategic uncertainty in games. In social settings, activity in this network is modulated by the level of strategic thinking that is reflected in the activity of the dorsomedial and dorsolateral prefrontal cortex. These results suggest that strategic uncertainty is resolved by the interplay between the neural circuits mediating risk and higher order beliefs (i.e. beliefs about others’ beliefs).
A SNAKE-BASED SEGMENTATION ALGORITHM FOR OBJECTS

Concavities in the boundary of an object pose a challenge to active contour (snake) methods. In this paper, we present a snake-based scheme for efficiently detecting contours of objects with boundary concavities. The proposed method is composed of two steps. First, the object's boundary is detected using the proposed snake model. Second, snake points are optimized by inserting new points and deleting unnecessary points to better describe the object's boundary. The proposed algorithm can successfully extract objects with boundary concavities, and is insensitive to the number of initial snake points. Experimental results have shown that our algorithm produces more accurate segmentation results than the conventional algorithm.
mental health care for people who identify as lesbian, gay, bisexual, transgender, and (or) queer.

The Canadian Psychiatric Association (CPA) has taken a strong position in advocating for decreasing stigma and discrimination, albeit, mostly with a focus on people with mental illness. While doing so, however, the CPA has recognized the ongoing stigma and discrimination in society based on sex, race, sexual orientation and religion.1 Unfortunately, psychiatry has a history of conflating lesbian, gay, bisexual, transgender and (or) queer (LGBTQ) identities with mental illness and has, therefore, historically contributed to the stigma and discrimination faced by people who identify as LGBTQ, affecting not only their mental health but also their access to appropriate mental health care. This position paper addresses the need for psychiatrists to increase their understanding of the mental health needs of people who identify themselves as LGBTQ.
[Pregnancy in lupus patients: our experience].

AIM Systematic lupus erythematosus (SLE) is the most common autoimmune disease associated with pregnancy. The aim of this study was to evaluate management and outcome of pregnancy complicated by SLE. METHODS Twenty pregnant women affected by SLE were admitted to Prenatal Diagnosis Centre of University "Sapienza" from January 2007 to July 2009. Pregnancy was monitored from diagnosis to delivery by at least a monthly consultation. At each visit general blood laboratory assessment were registered. An ultrasound examination was performed to evaluate fetal growth. From 26 weeks of gestation an estimation of fetal weight was calculated according to the standard of Lubchenco. At birth newborns weight was registered. RESULTS Patient mean age was 32.9 years. There were 18 live births (90%), and 2 spontaneous abortions; 50% of pregnancy ended with a preterm delivery. 20% of the patient had signs of disease activity during pregnancy. Fifteen percent of women presented gestational hypertension. An high rate of small for gestational age was registered and 2 cases of intrauterine growth retardation (IUGR). Ultrasound evaluation at 28-30 weeks of gestation showed a normal weight (≥ 50th percentile) in 83% fetuses. Only 45% of the newborns presented ≥ 50th percentile. The mean weight of the newborns was 2700 grams. CONCLUSION Pregnancy outcome could be improved by close obstetrical and ultrasound monitoring in a multidisciplinary setting.
Structural Stability of Turbulent Jets

Turbulence in fluids is commonly observed to coexist with relatively large spatial and temporal scale coherent jets. These jets may be steady, vacillate with a definite period, or be irregular. A comprehensive theory for this phenomenon is presented based on the mutual interaction between the coherent jet and the turbulent eddies. When a sufficient number of statistically independent realizations of the eddy field participate in organizing the jet a simplified asymptotic dynamics emerges with progression, as an order parameter such as the eddy forcing is increased, from a stable fixed point associated with a steady symmetric zonal jet through a pitchfork bifurcation to a stable asymmetric jet followed by a Hopf bifurcation to a stable limit cycle associated with a regularly vacillating jet and finally a transition to chaos. This underlying asymptotic dynamics emerges when a sufficient number of ensemble members is retained in the stochastic forcing of the jet but a qualitative different mean jet dynamics is found when a small number of ensemble members is retained as is appropriate for many physical systems. Example applications of this theory are presented including a model of midlatitude jet vacillation, emergence and maintenance of multiple jets in turbulent flow, a model of rapid reorganization of storm tracks as a threshold in radiative forcing is passed, and a model of the quasi-biennial oscillation. Because the statistically coupled wave‐mean flow system discussed is generally globally stable this system also forms the basis for a comprehensive theory for equilibration of unstable jets in turbulent shear flow.
Aortic Stiffness Is an Independent Predictor of Progression to Hypertension in Nonhypertensive Subjects

Aortic stiffness may predict progression to hypertension beyond classic risk factors. In a longitudinal study, we assessed the predictive value of aortic stiffness on future hypertension in nonhypertensive subjects with blood pressure (BP) <140/90. Aortic stiffness was determined by echocardiography at baseline in 2512 subjects. The follow-up time was 4 years. A stepwise increase in hypertension incidence occurred across the male and older participants: 3.8% of young female individuals, 11.5% of young male, 26.1% of old female, and 58.8% of old male subjects progressed to hypertension over 4 years. In multivariate analysis, aortic stain, distensibility, and stiffness index (&bgr;) remained significantly associated with the progression to future hypertension after adjustment to classic risk factors in men and women and in young and old populations. This study provides the first direct evidence to our knowledge in a longitudinal study that aortic stiffness is an independent predictor of progression to hypertension in nonhypertensive individuals.
Minimal spatio-temporal database repairs

This work tackles the management of novel types of inconsistencies in Spatio-Temporal Databases, different from traditional database settings where integrity constraints pertain to the explicitly stored (or, defined via views and aggregates) values. We observe that spatio-temporal data has its specific types of ßemanticconstraints and we aim at minimization of the changes needed for repairing their violations.
Primary care management of tuberous sclerosis complex in children

Purpose: To provide primary care providers with a general overview of the genetic disorder tuberous sclerosis complex (TSC). By understanding the disease mechanism for this genetic condition, providers can effectively care for TSC patients and properly educate families who are affected by TSC. The article also describes the multi‐system clinical presentation of the disease to assist primary care providers with an early diagnosis. Data Resources: Research articles and evidence‐based guidelines found through MEDLINE and the World Wide Web. Conclusions: Using various diagnostic tools and treatment options, providers can offer the multidisciplinary approach needed to manage this disease appropriately. New treatment options, such as rapamycin, may be the future drug of choice in treating TSC. Implications for practice: By following evidence‐based clinical practice guidelines, providers can hope to reduce TSC‐related morbidity and mortality.
In vivo neurotrophic effects of GDNF on axotomized retinal ganglion cells

THE identification of neurotrophic factors ameliorating secondary neuronal death in the mammalian CNS has raised hopes for improved treatment strategies in neurodegenerative diseases, CNS trauma and ischemia. Glial cell-line derived neurotrophic factor (GDNF) has potent neuroprotective properties in both the CNS and PNS. We sought to investigate whether GDNF exerts survival promoting effects on axotomized retinal ganglion cells (RGCs) in the adult rat in vivo. Transection of the optic nerve induces delayed retrograde death of ∼85% of RGCs within 14 days. Intraocular GDNF rescued 21% of the RGCs which would otherwise have died after axotomy (34% of the normal control population), thereby extending the group of neuronal populations responsive to GDNF.
Discussion of “Conundrums with Uncertainty Factors”

I applaud Dr. Cooke’s highlighting the need to reconsider how uncertainty factors are developed and used in the risk assessment process. His mathematical analyses are interesting and important, but far more important is the general message that a combination of deductive reasoning, statistical inference, and expert judgment are necessary components of an improved process. In the following sections, I highlight some general issues and comment on Dr. Cooke’s principal points.