Miracle-dz/UniFAR-FTUs huggingface dataset:
Atrial Fibrillation detection by a subcutaneous monitoring device

The Reveal XT subcutaneous insertable cardiac monitor detects Atrial Fibrillation (AF) from the irregularity of the ventricular rhythm. This study is a first assessment of the AF detection performance using subcutaneous signals from implanted devices. Patients implanted with a Reveal XT device were monitored by a dedicated Holter system, recording the surface ECG and uplinked device data. Device detections of AF were reconstructed from the uplinked data and classified as either true positive, false positive and false negative using the surface ECG for reference. In a total of 82 Holter recordings from 60 patients, the mean AF episode detection sensitivity was 90.6% and 98.1% for AF episodes ges2 minutes and ges4 minutes, respectively. The mean episode PPV was 55.1%. False positive detections were clustered within a few patients with irregular rhythms that were not annotated as AF.
Symmetry Detection from RealWorld Images Competition 2013: Summary and Results

Symmetry is a pervasive phenomenon presenting itself in all forms and scales in natural and manmade environments. Its detection plays an essential role at all levels of human as well as machine perception. The recent resurging interest in computational symmetry for computer vision and computer graphics applications has motivated us to conduct a US NSF funded symmetry detection algorithm competition as a workshop affiliated with the Computer Vision and Pattern Recognition (CVPR) Conference, 2013. This competition sets a more complete benchmark for computer vision symmetry detection algorithms. In this report we explain the evaluation metric and the automatic execution of the evaluation workflow. We also present and analyze the algorithms submitted, and show their results on three test sets of real world images depicting reflection, rotation and translation symmetries respectively. This competition establishes a performance baseline for future work on symmetry detection.
Comparison of plain and hyperbaric solutions of ropivacaine for spinal anaesthesia.

BACKGROUND Preliminary work has shown that ropivacaine provides spinal anaesthesia of shorter duration than bupivacaine, and may be of particular use in the day-case setting. However, there are few data comparing the actions of plain and hyperbaric solutions of this drug. METHODS Forty ASA grade I-II patients undergoing elective perineal surgery under spinal anaesthesia were randomized to receive 3 ml ropivacaine 5 mg ml(-1), either in plain solution or with glucose 50 mg ml(-1). The extent and duration of sensory and motor block, pulse rate, blood pressure, and time to mobilization were recorded. RESULTS Two patients (one per group) were withdrawn because of total block failure. There were significant differences in median time to onset of sensory block at T10 (plain 10 min; hyperbaric 5 min; P<0.01), median maximum extent (plain T8; hyperbaric T4; P<0.05), and median duration of sensory block at T10 (plain 25 min; hyperbaric 115 min; P<0.001). However, median times to complete regression of both sensory (270 vs 240 min; P<0.05) and motor (180 vs 120 min; P<0.001) block were longer in the plain group. Patients therefore mobilized sooner in the hyperbaric group (218 [n=16] vs 286 min [n=17]; P<0.01). All the hyperbaric blocks were adequate for surgery, but three patients receiving plain ropivacaine required general anaesthesia. CONCLUSION Addition of glucose 50 mg ml(-1) to ropivacaine 5 mg ml(-1) increases the speed of onset, block reliability, duration of useful block for perineal surgery, and speed of recovery. Plain solutions are less reliable for surgery above a dermatomal level of L1.
Performance assessment of an insect-inspired target tracking model in background clutter

Biological visual systems provide excellent examples of robust target detection and tracking mechanisms capable of performing in a wide range of environments. Consequently, they have been sources of inspiration for many artificial vision algorithms. However, testing the robustness of target detection and tracking algorithms is a challenging task due to the diversity of environments for applications of these algorithms. Correlation between image quality metrics and model performance is one way to deal with this problem. Previously we developed a target detection model inspired by physiology of insects and implemented it in a closed loop target tracking algorithm. In the current paper we vary the kinetics of a salience-enhancing element of our algorithm and test its effect on the robustness of our model against different natural images to find the relationship between model performance and background clutter.
HCI for the Masses: Multidisciplinary Design Instruction with LINK-UP

While the discipline of human-computer interaction is beginning to benefit from knowledge capture and reuse methods, lacking are effective tools to provide students with the breadth of knowledge and the importance of multidisciplinary exchanges that are vital to productive scientific disciplines. Our ongoing work on the LINK-UP knowledge management and reuse system provides the basis for multidisciplinary exchanges of knowledge among students by leveraging falsifiable hypotheses called claims. This pap er describes three case studies, extracted from different disciplines or environments, in which students extract claims from prior work in an effort to better understand the design decisions made.
Exceptional bundles associated to degenerations of surfaces

In 1981 J. Wahl described smoothings of surface quotient singularities with no vanishing cycles. Given a smoothing of a projective surface X of this type, we construct an associated exceptional vector bundle on the nearby fiber Y in the case H^{2,0}(Y)=H^1(Y)=0. If Y is the projective plane we show that our construction establishes a bijective correspondence between the possible degenerate surfaces X and exceptional bundles on Y modulo dualizing and tensoring by line bundles. If Y is of general type then our construction establishes a connection between components of the boundary of the moduli space of surfaces deformation equivalent to Y and exceptional bundles on Y.
Roles of cell confluency and fluid shear in 3-dimensional intracellular forces in endothelial cells

We use a novel 3D inter-/intracellular force microscopy technique based on 3D traction force microscopy to measure the cell–cell junctional and intracellular tensions in subconfluent and confluent vascular endothelial cell (EC) monolayers under static and shear flow conditions. We found that z-direction cell–cell junctional tensions are higher in confluent EC monolayers than those in subconfluent ECs, which cannot be revealed in the previous 2D methods. Under static conditions, subconfluent cells are under spatially non-uniform tensions, whereas cells in confluent monolayers are under uniform tensions. The shear modulations of EC cytoskeletal remodeling, extracellular matrix (ECM) adhesions, and cell–cell junctions lead to significant changes in intracellular tensions. When a confluent monolayer is subjected to flow shear stresses with a high forward component comparable to that seen in the straight part of the arterial system, the intracellular and junction tensions preferentially increase along the flow direction over time, which may be related to the relocation of adherens junction proteins. The increases in intracellular tensions are shown to be a result of chemo-mechanical responses of the ECs under flow shear rather than a direct result of mechanical loading. In contrast, the intracellular tensions do not show a preferential orientation under oscillatory flow with a very low mean shear. These differences in the directionality and magnitude of intracellular tensions may modulate translation and transcription of ECs under different flow patterns, thus affecting their susceptibility for atherogenesis.
Blast Overpressure Waves Induce Transient Anxiety and Regional Changes in Cerebral Glucose Metabolism and Delayed Hyperarousal in Rats

Physiological alterations, anxiety, and cognitive disorders are strongly associated with blast-induced traumatic brain injury (blast TBI), and are common symptoms in service personnel exposed to blasts. Since 2006, 25,000–30,000 new TBI cases are diagnosed annually in U.S. Service members; increasing evidence confirms that primary blast exposure causes diffuse axonal injury and is often accompanied by altered behavioral outcomes. Behavioral and acute metabolic effects resulting from blast to the head in the absence of thoracic contributions from the periphery were examined, following a single blast wave directed to the head of male Sprague-Dawley rats protected by a lead shield over the torso. An 80 psi head blast produced cognitive deficits that were detected in working memory. Blast TBI rats displayed increased anxiety as determined by elevated plus maze at day 9 post-blast compared to sham rats; blast TBI rats spent significantly more time than the sham controls in the closed arms (p < 0.05; n = 8–11). Interestingly, anxiety symptoms were absent at days 22 and 48 post-blast. Instead, blast TBI rats displayed increased rearing behavior at day 48 post-blast compared to sham rats. Blast TBI rats also exhibited suppressed acoustic startle responses, but similar pre-pulse inhibition at day 15 post-blast compared to sham rats. Acute physiological alterations in cerebral glucose metabolism were determined by positron emission tomography 1 and 9 days post-blast using 18F-fluorodeoxyglucose (18F-FDG). Global glucose uptake in blast TBI rat brains increased at day 1 post-blast (p < 0.05; n = 4–6) and returned to sham levels by day 9. Our results indicate a transient increase in cerebral metabolism following a blast injury. Markers for reactive astrogliosis and neuronal damage were noted by immunoblotting motor cortex tissue from day 10 post-blast in blast TBI rats compared to sham controls (p < 0.05; n = 5–6).
Relationship between physical metrics and game success with elite rugby sevens players

Abstract The purpose of this study was to use self-organising maps (SOMs) to visualise the multivariate relationship between physical metrics (PM’s) as measured by GPS and how they relate to a performance outcome in elite-level 7s rugby. The players heart rate was elevated in the high intensity zone for an average of 73% per game and covered an average distance of 1574 m. Over this distance, 22% of the time was spent high-speed running and a relative distance of 112 m/min was travelled. SOMs showed no reliable relationship between PMs and points difference while two groups of PMs demonstrated similar patterns. This included variables such as high-speed running and metabolic power in the first group and all of the body composition variables in the second group. The final group of variables, including RPE had no relationship with any of the other PM variables. High-speed running and metabolic power are related closely and provide information that can be used for the preparation of 7s specific training schedules. RPE was shown to be unreliable as it did not relate well to any of the PMs.
Control of chondrocyte gene expression by actin dynamics: a novel role of cholesterol/Ror-α signalling in endochondral bone growth

Elucidating the signalling pathways that regulate chondrocyte differentiation, such as the actin cytoskeleton and Rho GTPases, during development is essential for understanding of pathological conditions of cartilage, such as chondrodysplasias and osteoarthritis. Manipulation of actin dynamics in tibia organ cultures isolated from E15.5 mice results in pronounced enhancement of endochondral bone growth and specific changes in growth plate architecture. Global changes in gene expression were examined of primary chondrocytes isolated from embryonic tibia, treated with the compounds cytochalasin D, jasplakinolide (actin modifiers) and the ROCK inhibitor Y27632. Cytochalasin D elicited the most pronounced response and induced many features of hypertrophic chondrocyte differentiation. Bioinformatics analyses of microarray data and expression validation by real‐time PCR and immunohistochemistry resulted in the identification of the nuclear receptor retinoid related orphan receptor‐α (Ror‐α) as a novel putative regulator of chondrocyte hypertrophy. Expression of Ror‐α target genes, (Lpl, fatty acid binding protein 4 [Fabp4], Cd36 and kruppel‐like factor 5 [Klf15]) were induced during chondrocyte hypertrophy and by cytochalasin D and are cholesterol dependent. Stimulation of Ror‐α by cholesterol results in increased bone growth and enlarged, rounded cells, a phenotype similar to chondrocyte hypertrophy and to the changes induced by cytochalasin D, while inhibition of cholesterol synthesis by lovastatin inhibits cytochalasin D induced bone growth. Additionally, we show that in a mouse model of cartilage specific (Col2‐Cre) Rac1, inactivation results in increased Hif‐1α (a regulator of Rora gene expression) and Ror‐α+ cells within hypertrophic growth plates. We provide evidence that cholesterol signalling through increased Ror‐α expression stimulates chondrocyte hypertrophy and partially mediates responses of cartilage to actin dynamics.
An efficient pricing algorithm for swing options based on fourier cosine expansions

Swing options give contract holders the right to modify amounts of future delivery of certain commodities, such as electricity or gas. In this paper, we assume that these options can be exercised at any time before the end of the contract, and more than once. However, a recovery time between any two consecutive exercise dates is incorporated as a constraint to avoid continuous exercise. We introduce an efficient way of pricing these swing options, based on the Fourier cosine expansion method, which is especially suitable when the underlying is modeled by a Levy process.
Computation of Extreme Pathways with Hierarchical Decompositions of Metabolic Network

Intrinsic hierarchical structure of metabolic networks has been recently revealed [1]. Particular hierarchical decompositions can even present a property of relative independence between its branches which has been shown to be of a biological relevance. Here we use this property for computational purposes. A recursive and parallelizable variant of the classical algorithm for computing extreme pathways is hence introduced.
Intelligent Database Flexible Querying System by Approximate Query Processing

Database flexible querying is an alternative to the classic one for users. The use of Formal Concepts Analysis (FCA) makes it possible to make approximate answers that those turned over by a classic DataBase Management System (DBMS). Some applications do not need exact answers. However, flexible querying can be expensive in response time. This time is more significant when the flexible querying require the calculation of aggregate functions ("Sum", "Avg", "Count", "Var" etc.). In this paper, we propose an approach which tries to solve this problem by using Approximate Query Processing (AQP).
Impact of Spatial Correlation and Precoding Design in OSTBC MIMO Systems

The impact of transmission design and spatial correlation on the symbol error rate (SER) is analyzed for multi-antenna communication links. The receiver has perfect channel state information (CSI), while the transmitter has either statistical or no CSI. The transmission is based on orthogonal space-time block codes (OSTBCs) and linear precoding. The precoding strategy that minimizes the worst-case SER is derived for the case when the transmitter has no CSI. Based on this strategy, the intuitive result that spatial correlation degrades the SER performance is proved mathematically. In the case when the transmitter knows the channel statistics, the correlation matrix is assumed to be jointly-correlated (a generalization of the Kronecker model). The eigenvectors of the SER-optimal precoding matrix are shown to originate from the correlation matrix and the remaining power allocation is a convex problem. Equal power allocation is SER-optimal at high SNR. Beamforming is SER-optimal at low SNR, or for increasing constellation sizes, and its optimality range is characterized. A heuristic low-complexity power allocation is proposed and evaluated numerically. Finally, it is proved analytically that receive-side correlation always degrades the SER. Transmit-side correlation will however improve the SER at low to medium SNR, while its impact is negligible at high SNR.
SecYEG assembles into a tetramer to form the active protein translocation channel

Translocase mediates preprotein translocation across the Escherichia coli inner membrane. It consists of the SecYEG integral membrane protein complex and the peripheral ATPase SecA. Here we show by functional assays, negative‐stain electron microscopy and mass measurements with the scanning transmission microscope that SecA recruits SecYEG complexes to form the active translocation channel. The active assembly of SecYEG has a side length of 10.5 nm and exhibits an ∼5 nm central cavity. The mass and structure of this SecYEG as well as the subunit stoichiometry of SecA and SecY in a soluble translocase–precursor complex reveal that translocase consists of the SecA homodimer and four SecYEG complexes.
TP53 Binding to BRCA1 and RAD51 in MCF7 and MDA-MB-468 Breast Cancer Cell Lines In vivo and In vitro

Background: Tumour suppressor genes such as TP53, BRCA1 and RAD51 are involved in DNA repair and their malfunctions result in genomic instability and cancer. Wild type (WT) TP53 binds to BRCA1and RAD51 in vivo and in vitro. However, mutated TP53 in tumours can interfere with WT TP53 function. We studied how mutation of TP53 in MDA-MB-468 cell line could affect its binding capacity and interfere with WT TP53 interaction with these DNA repair proteins. Methods: Binding capacity of mutated TP53 in MDA-MB-468 breast cancer cell line to BRCA1 and RAD51 proteins in comparison to WT TP53 in MCF7 cell line was studied by Immunoprecipitation. In vitro studies were performed by GST-WT p53 pull-down assays in these cell lines to assess the interaction of GST-WT p53 with BRCA1 and RAD51 proteins. Results: The results showed that mutated TP53 in MDA-MB-468 cells interacted with BRCA1 protein in vivo and did not effect WT TP53 binding to this protein in vitro. The Immunoprecipitation assays revealed that the mutated TP53 did not bind to RAD51 in comparison to WT TP53. However, this mutated protein could not interfere with binding of RAD51 to GST-WT p53 in MDA-MB-468 cell line by in vitro experiment. Conclusion: It was found that WT TP53 interactions with BRCA1 and RAD51 did not interfere with mutated TP53 in MDA-MB-468 cell line. In addition, RAD51 did not bind to TP53 with R273C mutation in vivo.
Sensory Integration: Theory and Practice

Sensory Integration. 3 Alma Jean Ayres Baker.3 Overview of Sensory Integration. 3 The three major postulates of sensory integration theory are:. 4 Relevant postural indicators include:. 4 Sensory Modulation Disorders.5 Assumptions of Sensory Integration Theory.5 1: The Central Nervous System is Plastic.5 2: Sensory Integration Develops (pg 11). 5 3: The brain functions as an Integrated Whole. 6 4: Adaptive Interactions are Critical to Sensory Integration.6 The Mind-Brain-Body Process. 6 Development of Sensory Integration Theory: History and Research.6 Factor-Analytic and Related Studies.6 The patterns of dysfunction that appeared most consistently included:. 7 The patterns that emerged from the factor and cluster analyses of the SIPT data included:. 7 Neuro-physiology considerations.7 The Somatosensory System. 9 The hypersensitive child who shows intolerance for touch may:. 9 The hyposensitive child who shows an increased tolerance for touch may:. 9 The hypersensitive child who shows poor awareness of their body may:. 10 The hyposensitive child who shows poor awareness of their body may:. 10 The Vestibular System. 12 The hypersensitive child who shows intolerance for movement may:. 12 The child with gravitational insecurity may:. 12 The hyposensitive child with increased tolerance for movement may:. 13 The Auditory System. 14 The hypersensitive child who shows intolerance for auditory stimuli may:. 15 The hyposensitive child who shows increased tolerance for auditory stimuli may:. 15 Auditory Processes.16 Auditory Discrimination. 16 Auditory Memory.17 Auditory Perception. 17 Auditory-Vocal Association. 18 Auditory Synthesis. 18 Auditory-vocal Automaticity. 18 Auditory Figure-Ground. 18 Reading Skills: For a child with a problem in the auditory processes. 19 The Visual System. 20 The hypersensitive child who shows intolerance for visual stimuli may:. 20 The hyposensitive child who shows increased tolerance for visual stimuli may:. 20 Eyesight vs. Vision. 20 Ocular Pursuits.21
An Alternative Use of Horticultural Crops: Stressed Plants as Biofactories of Bioactive Phenolic Compounds

Plants subjected to abiotic stresses synthesize secondary metabolites with potential application in the functional foods, dietary supplements, pharmaceutical, cosmetics and agrochemical markets. This approach can be extended to horticultural crops. This review describes previous reports regarding the effect of different postharvest abiotic stresses on the accumulation of phenolic compounds. Likewise, the physiological basis for the biosynthesis of phenolic compounds as an abiotic stress response is described. The information presented herein would be useful for growers and the fresh produce market which are interested in finding alternative uses for their crops, especially for those not meeting quality standards and thus are considered as waste.
Joint Topology Control and Routing in IEEE 802.11-Based Multiradio Multichannel Mesh Networks

Due to low cost, ease of deployment, increased coverage, and enhanced capacity, multiradio mesh networks that utilize inexpensive and readily available Institute of Electrical and Electronics Engineers (IEEE) 802.11 wireless interfaces are touted as the new frontier of wireless networking. In a multihop mesh system, the close interaction between topology control and routing selection affects the system throughput of a wireless network. This paper proposes a novel joint topology control and routing (JTCR) protocol for a multiradio multichannel wireless mesh network to exploit both channel diversity and spatial reusability. It resides between medium access control and the network layer and aims to improve the network throughput by coordinating transmission power, channel assignment, and route selection among multiple nodes in a distributed way. JTCR jointly coordinates the transmission power at each node, the channel selection on each wireless interface, and the route selection among interfaces based on the traffic information that is measured and exchanged among two-hop neighbor nodes. An equivalent channel air time metric (ECATM) is presented to quantify the difference of various adjustment candidates. This protocol achieves the efficient utilization of available channels by selecting a feasible adjustment candidate with the smallest EC ATM value and coordinating affected nodes to realize the adjustment. Our NS-2-based simulation results show that the network throughput can be significantly improved by using our proposed solution.