Miracle-dz/UniFAR-FTUs huggingface dataset:
Principles and mechanisms of CD95 activation

Abstract CD95 (Apo1/Fas) has been originally identified as the target of cell death-inducing antibodies. The recognition of CD95 as an apoptosis-triggering receptor represents one of the early milestones in the apoptosis field. Moreover, the research on CD95-induced cell death fostered various other discoveries of broad and general relevance in cell biology, for example, the identification of caspase 8 as the initiator caspase of the extrinsic apoptosis pathway. Activation of CD95-associated intracellular signaling pathways is not a simple consequence of ligand binding but is the fine-tuned result of a complex interplay of various molecular mechanisms that eventually determine the strength and quality of the CD95 response. There is growing evidence that different forms of CD95 stimulation trigger the assembly of CD95 signaling complexes of distinct composition. Moreover, the formation of signaling competent CD95 complexes is a multistep process and the subject of regulation by various cellular cues. This review addresses the relevance of the molecular nature of the CD95-stimulating agonist for the quality of the CD95 response and discusses the importance of modification, clustering, internalization, and lipid raft and actin association of CD95 for CD95 activity.
The frequency of disorders of the lower urinary tract, urinary incontinence in particular, as evaluated by a questionnaire survey in a gynecological health control population

Four thousand four hundred women were examined under the gynecological health control program in Malmö municipality during a period of 11 months. Nine hundred and forty‐four (21 per cent) reported that they were troubled by disorders of the urinary tract. These women were given copies of a separate questionnaire, which was subsequently properly answered by 512 women. Of these, 321 (62.7 per cent) indicated urinary incontinence. From the questionnaire alone, it was difficult to characterize the different types of urinary incontinence in the patients. Thus only 42 women (8.2 per cent) seemed to suffer from genuine stress incontinence and 34 women (6.6 per cent) from genuine urge incontinence, whereas 245 (47.9 per cent) had to be characterized as “mixed incontinent”. Hence, it is obvious that in several patients suffering from urinary incontinence, written or combined written and oral interviews do not produce a clear‐cut diagnosis and that the etiology and treatment of incontinence in these patients may be uncertain. It is concluded that interviews with most patients suffering from urinary incontinence must be supplemented by objective recordings before a definitive diagnosis and treatment can be prescribed.
Midlatency Auditory Evoked Potentials and Explicit and Implicit Memory in Patients Undergoing Cardiac Surgery

BackgroundA high incidence of intraoperative awareness during cardiac surgery has been reported. Midlatency auditory evoked potentials (MLAEP) have been used recently as an indicator of awareness. In the current study, memory for information presented during anesthesia was investigated using MLAEP as one experimental indicator in 45 patients scheduled for elective cardiac surgery. MethodsIn all patients general anesthesia was maintained using high-dosage fentanyl (1.2 mg · h−1). In addition, the patients of group 1 (n = 10) received flunitrazepam (1.2 mg · h−1), the patients of group 2 (n = 10) isoflurane (0.6–1.2 vol%), and the patients of group 3 (n = 10) propofol (4–8 mg · kg−1. h−1). Group 4 (n = 15) served as a control, and those patients were assigned randomly to one of the anesthetic regimes. After sternotomy and before cardiopulmonary bypass, an audiotape, which included an implicit memory task, was presented to the patients of groups 1–3. Auditory evoked potentials were recorded while the patients were awake and during general anesthesia immediately before and after the audiotape presentation. Latencies of the brain stem peak V and the early cortical potentials Na and Pa were measured. ResultsThree to 5 days postoperatively no patient had a clear explicit memory of intraoperative events. However, there were statistically significant differences in the incidence of implicit recall among the groups. Five patients in the flunitrazepam-fentanyl group, 1 patient in the isoflurane-fentanyl group, 1 patient in the propofol-fentanyl group, and no patient in the control group showed an implicit memory of the intraoperative tape message. In the awake state, MLAEP showed high peak-to-peak amplitudes and a periodic waveform. In the patients with implicit memory postoperatively, MLAEP continued to show this pattern during general anesthesia. The early cortical potentials Na and Pa did not increase in latency or decrease in amplitude before or after the audiotape presentation. In contrast, in the patients without implicit memory, MLAEP waveform was severely attenuated or abolished. Na and Pa showed marked increases in latencies and decreases in amplitudes or were completely suppressed. In 9 patients, including all patients (7 of 9) with implicit memory, Pa latency increased less than 12 ms, and 21 of 23 patients without implicit memory showed a Pa latency increase of greater than 12 ms during anesthesia and the audiotape presentation. Therefore, the Pa latency increase of greater or less than 12 ms may provide sensitivity of 100% and specificity of 77% in distinguishing patients with implicit memory from patients without implicit memory postoperatively. ConclusionsWhen the early cortical potentials of MLAEP are preserved during general anesthesia, auditory information may be processed and remembered postoperatively by an implicit memory task.
(Re)Applying social psychology to organizational work, well‐being, and leadership

Research on organizational behavior is fundamentally an application of social psychology theory and phenomena. While much of organizational psychology is inherently grounded in social psychological research, these two disciplines are largely disconnected from one another. More visibility of the commonalities may encourage discussion, collaboration, and integration between these two fields—an integration that will only benefit each discipline. The present article briefly reviews the historic overlap between these disciplines, the resulting divide between them, and then discusses recent developments demonstrating the potential power of reconnecting social psychology with organizational-relevant research. We then examine how the six empirical articles in this Special Issue benefit from applying social psychological theory to organizational research. We will conclude by identifying potential areas ripe for future research.
A Real Time EDAC System for Applications Onboard Earth Observation Small Satellites

Onboard error detection and correction (EDAC) devices aim to secure data transmitted between the central processing unit (CPU) of a satellite onboard computer (OBC) and its local memory. A follow-up is presented here of some low-complexity EDAC techniques for application in random access memories (RAMs) onboard the Algerian microsatellite Alsat-1. The application of a double-bit EDAC method is described and implemented in field programmable gate array (FPGA) technology. The performance of the implemented EDAC method is measured and compared with three different EDAC strategies, using the same FPGA technology. A statistical analysis of single-event upset (SEU) and multiple-bit upset (MBU) activity in commercial memories onboard Alsat-1 is given. A new architecture of an onboard EDAC device for future Earth observation small satellite missions in low Earth orbits (LEO) is described.
Asymptomatic Carotid Stenosis: Risk of Progression and Development of Symptoms

Background: The aim of this study is to evaluate the rate of progression of stenosis and development of symptoms in patients with asymptomatic carotid artery stenosis (aCAS) treated with contemporary medical therapy over a prolonged time interval. Methods: This study is a retrospective review of consecutive patients diagnosed with moderate or severe aCAS at our institution between 2000 and 2001. Data were gathered from both carotid arteries for each patient excluding vessels operated within 1 year of diagnosis and occlusions. Multivariate analysis was performed to analyze factors associated with ipsilateral transient ischemic attack (TIA)/stroke. Results: We identified 214 patients (58.8% men; median age 70 years) and collected data on 349 vessels. Degree of stenosis was severe (>70%) upon diagnosis in 92 (26.4%) vessels. Median length of follow-up was 13 years (interquartile range 10-14), and mean number of time points for follow-up imaging were 8.1 ± 3.9. Progression of stenosis was observed in 237 (67.9%) vessels, and 72 (20.6%) patients developed symptoms ipsilateral to the stenosis (TIA in 14.4%, non-disabling stroke in 4%, disabling stroke in 2.2%). Median time to appearance of first symptom was 6 years (range 1-13). On multivariate analysis, degree of baseline stenosis, intracranial stenosis >50%, plaque ulceration, silent infarction and previous history of TIA/stroke were associated with ipsilateral TIA/stroke, but progression of stenosis was not. Conclusions: There was a substantial rate of progression of stenosis in patients with aCAS over time despite adequate medical therapy, but progression of stenosis did not increase the risk of ipsilateral TIA/stroke. Over long-term follow-up, 1 in 5 patients with aCAS developed ipsilateral TIA/stroke, though most events were either transient or non-disabling.
Fetal growth according to different reference ranges in twin pregnancies with placental insufficiency

The aim of this study was to compare different fetal growth curves in twin pregnancies with severe placental insufficiency. A retrospective cross-sectional analysis of 47 twin pregnancies with absent or reverse end diastolic flow in the umbilical artery of one fetus was performed. Pregnancies with major fetal abnormalities, twin-twin transfusion or three or more fetuses were not included. The estimated fetal weight zeta-scores were calculated for both fetuses (abnormal Doppler and co-twin) according to the following criteria: Hadlock, Liao and Araújo. The abdominal circumference zeta-scores were calculated according to Hadlock, Liao, Araújo, Ong and Stirrup. The mean estimates of the zeta-score values were calculated using generalized estimating equation regression analysis. The mean gestational age at inclusion was 27.4±4.7 weeks. The fetal sex and the interaction Doppler findings × criteria correlated significantly with the zeta-score values (p<0.001 for both variables). The estimated fetal weight mean zeta-scores (standard error) according to each criteria were as follows: Hadlock - abnormal Doppler: -2.98 (0.18), co-twin: -1.16 (0.15); Liao - abnormal Doppler: -2.89 (0.24), co-twin: -0.58 (0.19); and Araújo - abnormal Doppler: -3.05 (0.29), co-twin: -0.75 (0.18). Values for abdominal circumference were as follows: Hadlock - abnormal Doppler: -3.14 (0.26), co-twin: -1.13 (0.19); Liao - abnormal Doppler: -2.63 (0.27), co-twin: -0.42 (0.19); Araújo - abnormal Doppler: -2.44 (0.22), co-twin: -0.71 (0.14); Ong - abnormal Doppler: -3.36 (0.34), co-twin: -1.48 (0.23); and Stirrup AD -- -2.36 (0.14), co-twin: -1.18 (0.10). Sex- and plurality-specific charts should be used in the evaluation of fetal growth in twin pregnancies with placental insufficiency.
Energy Efficient Architecture Using Hardware Acceleration for Software Defined Radio Components

In order to make cognitive radio systems a practical technology to be dep- loyed in real-world scenarios, the core Software Defined Radio (SDR) systems must meet the stringent requirements of the target application, especially in terms of perfor- mance and energy consumption for mobile platform. In this paper we present a feasibili- ty study of hardware acceleration as an energy-efficient implementation for SDR. We identified the amplifier function from the Software Communication Architecture (SCA) for hardware acceleration since it is one of the functions called most frequently and requires intensive floating-point computation. Then, we used the Virtex5 Field-Programmable Gate Array (FPGA) to perform a comparison between compiler floating-point support and the on-chip floating-point support. By enabling the on-chip floating-point unit (FPU), we obtained as high as 2X speedup and 50% of overall energy reduction. We achieve this with an increase of the power consumption by no more than 0.68%. This demon- strates the feasibility of the proposed approach.
Angioarchitectural Factors Present in Brain Arteriovenous Malformations Associated With Hemorrhagic Presentation

Background and Purpose— Associations between clinical presentation of brain arteriovenous malformations (AVMs) and their angioarchitecture have been described. This study aims to identify significant factors related to the initial hemorrhagic event through multivariate statistical methodology. Methods— The authors studied the initial clinical presentation of 390 consecutive patients with brain AVMs at the University of Toronto Vascular Malformation Study Group. Angiographic features present at that time, such as location, size, and blood supply, were recorded following a standard protocol and associated, through multivariate analysis techniques, with type of presentation. Results— Patients had hemorrhagic presentation in 146 cases (37.4%). Hemorrhage was the initial presentation in 59.5% of the deep-seated AVMs (odds ratio [OR]=3.26; 95% CI=1.15 to 9.2;P =0.03). A single draining vein was associated with bleeding at presentation in 57.6% AVMs (OR=1.78; 95% CI=1.12 to 2.82;P =0.01), and 72.8% of the patients with venous ectasia had bleeding as initial evidence (OR=3.9; 95% CI=1.63 to 9.28;P =0.002). Hemorrhage was the initial presentation in 47.6% (111/233) of AVMs <3 cm, 22.5% (32/142) in sizes between 3 and 6 cm, and 20% in malformations >6 cm (3/15), but these differences were not significant in multivariate analyses. Conclusions— For initial hemorrhagic presentation, a small number of draining veins, deep location, and the presence of venous ectasias were significant associated factors. In contrast with many previous reports, AVM size was not associated with hemorrhage at presentation in adjusted analyses.
3-(4-Chlorophenyl)-2,1-benzisoxazole-5-carbonyl chloride

The molecule of the title compound, C14H7Cl2NO2, is not planar; the dihedral angle between the mean planes of the chlorophenyl and benzisoxazole rings is 20.32 (7)°. The carbonyl chloride group is twisted with respect to the benzisoxazole ring by 2.5 (1)°. The molecular conformation is stabilized by an intramolecular C—H⋯Cl hydrogen bond. In the crystal packing, adjacent molecules are linked into dimers by intermolecular C—H⋯O hydrogen bonds. The dimers are further stacked into columns along the unique axis direction by π–π stacking interactions, with a centroid⋯centroid distance of 3.828 (5) Å. Other weak intermolecular C—H⋯O and C—H⋯Cl interactions are also present.
The singing voice: rediscovering a diamond with many facets

One of the most contributing events for human’s evolution was the possibility for effective communication, which eventually has lead to the development of a unique musical instrument. The underlying complexity of the singing voice, reflected in its multidisciplinary nature, constitutes the focus of this presentation, shedding light into: (i) technology and singing education; (ii) aerodynamic and physiological aspects of voice evaluation and classification; (iii) biochemical aspects affecting vocal performance; and (iv) aspects of the singing voice in different musical and cultural backgrounds.
CASK and Dlg form a PDZ protein complex at the mammalian neuromuscular junction

Membrane‐associated guanylate kinases (MAGUKs) are modular adapter proteins that serve as scaffolding molecules and anchor channels and receptors via their PDZ (PSD‐95, Dlg, Zo‐1) domains. Calcium, calmodulin‐associated serine/threonine kinase (CASK) is a MAGUK that is critical at synapses in the central nervous system and at cell–cell junctions because of its interactions with channels, receptors, and structural proteins. We show via confocal microscopy that CASK and another MAGUK, Discs Large (Dlg), are present at the mammalian neuromuscular junction in skeletal muscle. Immunoprecipitation data from mouse muscle show that CASK associates with Dlg, providing evidence of a MAGUK protein complex at this synapse. These data indicate that CASK and Dlg may act as a scaffold for organizing receptors and channels at the postsynaptic membrane of the neuromuscular junction. Muscle Nerve 30: 164–171, 2004
DOLPHIN: An efficient algorithm for mining distance-based outliers in very large datasets

In this work a novel distance-based outlier detection algorithm, named DOLPHIN, working on disk-resident datasets and whose I/O cost corresponds to the cost of sequentially reading the input dataset file twice, is presented. It is both theoretically and empirically shown that the main memory usage of DOLPHIN amounts to a small fraction of the dataset and that DOLPHIN has linear time performance with respect to the dataset size. DOLPHIN gains efficiency by naturally merging together in a unified schema three strategies, namely the selection policy of objects to be maintained in main memory, usage of pruning rules, and similarity search techniques. Importantly, similarity search is accomplished by the algorithm without the need of preliminarily indexing the whole dataset, as other methods do. The algorithm is simple to implement and it can be used with any type of data, belonging to either metric or nonmetric spaces. Moreover, a modification to the basic method allows DOLPHIN to deal with the scenario in which the available buffer of main memory is smaller than its standard requirements. DOLPHIN has been compared with state-of-the-art distance-based outlier detection algorithms, showing that it is much more efficient.
A 3-D-Lumped Thermal Network Model for Long-Term Load Profiles Analysis in High-Power IGBT Modules

The conventional RC-lumped thermal networks are widely used to estimate the temperature of power devices, but they lack of accuracy in addressing detailed thermal behaviors/couplings in different locations and layers of the high-power insulated gate bipolar transistor (IGBT) modules. On the other hand, a finite-element (FE)-based simulation is the other method, which is often used to analyze the steady-state thermal distribution of IGBT modules, but it is not possible to be used for a long-term analysis of load profiles of power converter, which is needed for reliability assessments and better thermal design. This paper proposes a novel 3-D RC-lumped thermal network for the high-power IGBT modules. The thermal coupling effects among the chips and among the critical layers are modeled, and boundary conditions, including the cooling conditions, are also considered. It is demonstrated that the proposed thermal model enables both accurate and fast temperature estimation of high-power IGBT modules in the real loading conditions of the converter while maintaining the critical details of the thermal dynamics and thermal distribution. The proposed thermal model is verified by both the FE-based simulation and the experimental results.
Hourly Traffic Prediction of News Stories

ABSTRACT The process of predicting news stories popularity from several news sources has become a challenge of great importance for both news producers and readers. In this paper, we investigate methods for automatically predicting the number of clicks on a news story during one hour. Our approach is a combination of additive regression and bagging applied over a M5P regression tree using a logarithmic scale (log 10 ). The features included are social-based (social network metadata from Facebook), content-based (automatically extracted keyphrases, and stylometric statistics from news titles), and time-based. In 1 st Sapo Data Challenge we obtained 11.99% as mean relative error value which put us in the 4 th place out of 26 participants. Categories and Subject Descriptors H.3. 3 [ Information Search and Retrieval ]: Information filtering General Terms Algorithms , Measurement , Experimentation . Keywords Prediction, News, Clicks, Sapo Challenge, Traffic 1. INTRODUCTION
Language technology in knowledge-organization systems

This paper describes the language technology methods developed in the Danish research project VID to extract from Danish text material relevant information for the population of knowledge organization systems (KOS) within specific corporate domains. The results achieved by applying these methods to a prototype search engine tuned to the patent and trademark domain indicate that the use of human language technology can support the construction of a linguistically based KOS and that linguistic information in search improves recall substantially without harming precision (near 90%). Finally, we describe two research experiments where (1) linguistic analysis of Danish compounds and is exploited to improve search atrategies on these (2) linguistic knowledge is used to model corporate knowledge into a language-based ontology.
Multimedia Congestion Control: Circuit Breakers for Unicast RTP Sessions

The Real-time Transport Protocol (RTP) is widely used in telephony, video conferencing, and telepresence applications. Such applications are often run on best-effort UDP/IP networks. If congestion control is not implemented in these applications, then network congestion can lead to uncontrolled packet loss and a resulting deterioration of the user's multimedia experience. The congestion control algorithm acts as a safety measure by stopping RTP flows from using excessive resources and protecting the network from overload. At the time of this writing, however, while there are several proprietary solutions, there is no standard algorithm for congestion control of interactive RTP flows. This document does not propose a congestion control algorithm. It instead defines a minimal set of RTP circuit breakers: conditions under which an RTP sender needs to stop transmitting media data to protect the network from excessive congestion. It is expected that, in the absence of long-lived excessive congestion, RTP applications running on best-effort IP networks will be able to operate without triggering these circuit breakers. To avoid triggering the RTP circuit breaker, any Standards Track congestion control algorithms defined for RTP will need to operate within the envelope set by these RTP circuit breaker algorithms.
Artificial finger skin having ridges and distributed tactile sensors used for grasp force control

An artificial elastic finger skin for robot fingers was developed for controlling the grasp force when the weight and friction coefficient of the grasped object are unknown. The elastic finger skin has ridges at the surface to divide the stick/slip area. It also has a pair of tactile sensors embedded per one ridge similar to human fingertips. The surface of the whole finger is curved so that the reaction force can be distributed. A finite element (FE) model of the elastic finger skin was developed to perform a dynamic contact analysis using the FE method in order to design the elastic finger skin. The elastic finger skin was then constructed. It was confirmed by calculation and experiment that the incipient slippage of the ridge that occurs near the edge of contact area can be detected. This result is useful for controlling the grasping force when the weight and friction coefficient between the elastic finger skin and grasping object are unknown.