Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular Detection of Spotted-Fever Group Rickettsiae in Ticks Collected from Domestic and Wild Animals in Corsica, France

To obtain a better understanding of the current magnitude of tick-borne rickettsioses in Corsica, we used molecular methods to characterize the occurrence of Rickettsia spp. in ixodid ticks collected from domestic and wild animals. The presence of Rickettsia spp. was evaluated using real-time polymerase chain reaction targeting the gltA gene and by sequencing of gltA and ompA partial genes for species identification and phylogenetic analysis. Infection rates were calculated as the maximum-likelihood estimation (MLE) with 95% confidence intervals (CI). In total, 1117 ticks belonging to four genera (Rhipicephalus, Hyalomma, Ixodes, and Dermacentor) were collected from cattle, sheep, wild boars, and companion animals during July–August 2017 and July 2018–January 2019. Overall, Rickettsia DNA was detected in 208 of 349 pools of ticks (MLE = 25.6%, 95% CI: 22.6–28.8%). The molecular analysis revealed five different rickettsial species of the spotted-fever group (SFG). We highlighted the exclusive detection of Candidatus Ri. barbariae in R. bursa and of Ri. aeschlimanii in H. marginatum. Rickettsia slovaca was detected in D. marginatus collected from wild boars. This study provides the first evidence of the presence of Ri. monacensis in I. ricinus ticks isolated from a dog in Corsica. In conclusion, our data revealed wide dispersal of SFG Rickettsiae and their arthropod hosts in Corsica, highlighting the need for surveillance of the risk of infection for people living and/or working close to infected or infested animals.
Approaches for Quadtree-based Geographic Information Systems at Continental or Global Scales

Several alternative strategies for defining quadtrees and related recursive tesselations over the sphere are examined as possible bases for a global, quadtree-based geographic information system (CIS). We propose that the UTM coordinate system provides the most appropriate basis for such a CIS. The general structure of such a CIS is described.
Cromptodon mamiferoides gen. et sp. nov., Galesauridae de la Formacion Rio Mendoza, Mendoza, Argentina. (Therapsida- Cynodontia)

Both dentaries with several well preserved postcanines of a new Galesaurid from the Rio Mendoza Formation are described and figured. The postcanine morphology and distribution of the cups is very similar to Thrinaxodon liorhinus but the cingulum is lingually wider. The tooth replacement is of the alternate type, and the characters of the groove for the dental lamina suggest a condition more advanced than in Thrinaxodon. The dentary shows the coronoid, prearticular and angular processes more developed than in Thrinaxodon, and more similar to Tribolodon [rerensis from the Cynognathus Zone. The Therapsids found in association with this new Galesaurid, and the comparisons with the Argentinian Puesto Viejo and Los Chanares assamblages, and with the Cynognathus Zone suggest, on the basis of the available data, an uppermost Lower Triassic age for the Rio Mendoza tetrapods, which means the same age than the Puesto Viejo, but earlier than Los Chanares assamblages.
Resurgence of Ebola virus disease in guinea linked to a survivor with virus persistence in seminal fluid for more than 500 days

We report on an Ebola virus disease (EVD) survivor who showed Ebola virus in seminal ﬂ uid 531 days after onset of disease. The persisting virus was sexually transmitted in February 2016, about 470 days after onset of symptoms, and caused a new cluster of EVD in Guinea and Liberia.
Combination of hydrophobicity and codon usage bias determines sorting of model K+ channel protein to either mitochondria or endoplasmic reticulum

When the K+ channel‐like protein Kesv from Ectocarpus siliculosus virus 1 is heterologously expressed in mammalian cells, it is sorted to the mitochondria. This targeting can be redirected to the endoplasmic reticulum (ER) by altering the codon usage in distinct regions of the gene or by inserting a triplet of hydrophobic amino acids (AAs) into the protein's C‐terminal transmembrane domain (ct‐TMD). Systematic variations in the flavor of the inserted AAs and/or its codon usage show that a positive charge in the inserted AA triplet alone serves as strong signal for mitochondria sorting. In cases of neutral AA triplets, mitochondria sorting are favored by a combination of hydrophilic AAs and rarely used codons; sorting to the ER exhibits the inverse dependency. This propensity for ER sorting is particularly high when a common codon follows a rarer one in the AA triplet; mitochondria sorting in contrast is supported by codon uniformity. Since parameters like positive charge, hydrophobic AAs, and common codons are known to facilitate elongation of nascent proteins in the ribosome the data suggest a mechanism in which local changes in elongation velocity and co‐translational folding in the ct‐TMD influence intracellular protein sorting.
Perspectives of Swiss Paediatric Health Care Professionals on Factors Influencing Physical Activity Participation in Children with Disabilities

ABSTRACT Aim Investigation of the perspectives of paediatric health care professionals (PHCPs) in Switzerland regarding factors that influence participation in physical activity programs for children and adolescents with disabilities or chronic conditions (CADCCs). Evaluation of self-reported exercise counselling behavior of those professionals. Method A cross-sectional survey was used to collect the opinions of 171 PHCPs working with CADCCs using a structured questionnaire. The information obtained was evaluated by performing a combined quantitative and qualitative statistical analysis. Results PHCPs in Switzerland think that CADCC do not get enough physical activity and see the underlying reasons in lacking information/knowledge and organizational factors. We found that the level of knowledge about disability sports opportunities among PHCPs has a positive influence on their exercise counselling behaviour. Conclusions We propose three approaches to increase the level of physical activity in CADCC: Establishing personalized exercise counseling, intensifying information about disability sports programmes towards PHCPs, and improving inclusion and integration in PE lessons or regular sports clubs.
Can artificial intelligence separate the wheat from the chaff in systematic reviews of health economic articles?

ABSTRACT Objectives Artificial intelligence-powered tools, such as ASReview, could reduce the burden of title and abstract screening. This study aimed to assess the accuracy and efficiency of using ASReview in a health economic context. Methods A sample from a previous systematic literature review containing 4,994 articles was used. Previous manual screening resulted in 134 articles included for full-text screening (FT) and 50 for data extraction (DE). Here, accuracy and efficiency was evaluated by comparing the number of identified relevant articles with ASReview versus manual screening. Pre-defined stopping rules using sampling criteria and heuristic criteria were tested. Robustness of the AI-tool’s performance was determined using 1,000 simulations. Results Considering included stopping rules, median accuracy for FT articles remained below 85%, but reached 100% for DE articles. To identify all relevant articles, a median of 89.9% of FT articles needed to be screened, compared to 7.7% for DE articles. Potential time savings between 49 and 59 hours could be achieved, depending on the stopping rule. Conclusions In our case study, all DE articles were identified after screening 7.7% of the sample, allowing for substantial time savings. ASReview likely has the potential to substantially reduce screening time in systematic reviews of health economic articles.
Human‐modified landscapes driving the global primate extinction crisis

The world's primates have been severely impacted in diverse and profound ways by anthropogenic pressures. Here, we evaluate the impact of various infrastructures and human‐modified landscapes on spatial patterns of primate species richness, at both global and regional scales. We overlaid the International Union for the Conservation of Nature (IUCN) range maps of 520 primate species and applied a global 100 km2 grid. We used structural equation modeling and simultaneous autoregressive models to evaluate direct and indirect effects of six human‐altered landscapes variables (i.e., human footprint [HFP], croplands [CROP], road density [ROAD], pasture lands [PAST], protected areas [PAs], and Indigenous Peoples' lands [IPLs]) on global primate species richness, threatened and non‐threatened species, as well as on species with decreasing and non‐decreasing populations. Two‐thirds of all primate species are classified as threatened (i.e., Critically Endangered, Endangered, and Vulnerable), with ~86% experiencing population declines, and ~84% impacted by domestic or international trade. We found that the expansion of PAST, HFP, CROP, and road infrastructure had the most direct negative effects on primate richness. In contrast, forested habitat within IPLs and PAs was positively associated in safeguarding primate species diversity globally, with an even stronger effect at the regional level. Our results show that IPLs and PAs play a critical role in primate species conservation, helping to prevent their extinction; in contrast, HFP growth and expansion has a dramatically negative effect on primate species worldwide. Our findings support predictions that the continued negative impact of anthropogenic pressures on natural habitats may lead to a significant decline in global primate species richness, and likely, species extirpations. We advocate for stronger national and international policy frameworks promoting alternative/sustainable livelihoods and reducing persistent anthropogenic pressures to help mitigate the extinction risk of the world's primate species.
Municipal stormwater management in Denmark

This study was motivated by the outlook of climate changes, expectations of more stormwater in the future, and the potential impact of stormwater on receiving waters. The study set out to investigate how Danish municipalities balance stormwater management with environmental objectives as set out by the WFD and national law. The general aim was to understand if the current stormwater management practice could impede compliance with environmental objectives. After an outline of the legal frames for the practice, an interview study about the practice, with seven municipal water managers from four different municipalities, who process discharge permits, was carried out. The qualitative data was analysed through a practice theoretical perspective in order to understand the water managers’ way of reasoning and how they balance the need of stormwater discharge with environmental objectives. Some of the main impediments to compliance with environmental objectives were found to be lack of environmental data on receiving waters and a lack of knowledge about the pollution profile of stormwater. These two elements have created a practice where a low-tech treatment/delay facility is required in permits but no further consistent monitoring of the discharge is carried out. However, uncertainties remain about the efficiency of available technology and whether the use of the technologies perceived as Best Available Technology (BAT) is sufficient to comply with environmental objectives.
Strengthening Social Capital to Address Isolation and Loneliness in Long-Term Care Facilities During the COVID-19 Pandemic: Systematic Review of Research on Information and Communication Technologies

Background The COVID-19 pandemic has disproportionately and severely affected older adults, namely those living in long-term care facilities (LTCFs). Aside from experiencing high mortality rates, survivors were critically concerned by social isolation and loneliness (SIL). To address this serious public health concern and stay connected with LTCF residents, information and communication technology (ICT) platforms (eg, video calls) were used as an alternative to maintaining social interactions amid the visiting restriction policy. Objective This paper aimed to synthesize the effects of ICT-related communication interventions using SMS text messaging or chat, video, voice mail, or photo to address SIL in LTCF residents during the COVID-19 pandemic. Methods In total, 2793 references published in English and French in 2019 and onward were obtained from 10 relevant databases: PsycINFO-Ovid, Ovid-MEDLINE, CINAHL-EBSCO, Cochrane Library, Web of Science, Scopus, DirectScience, Communication & Mass Media Complete, IEEE Xplore, and ACM Digital Library. A 2-person screening approach was used, and the studies were screened independently and blindly. A narrative synthesis was performed to interpret the results of the included studies, and their quality was appraised. Results In total, 4 studies were included in the review. ICT-related applications were used to ensure connectedness to address SIL. ICT interventions consisted mainly of videoconferencing, intergroup video call sessions between residents, and chatting (SMS text messages and phone calls). Roughly 3 classes of mediating ICT tools were used: video calls using software applications (eg, Skype); robot systems embedding video telephones; and ordinary telecommunication such as telephone, internet, social media platforms, and videoconferencing. This review has included the role of humanoid robots in LTCFs as an innovation avenue because of their multipurpose use (eg, communication tools and remotely operable). Conclusions Remote social capitalization through ICT applications has become an avenue to reduce SIL among LTCF residents. This review examined a social connection approach that will remain relevant and even be fostered after the COVID-19 pandemic. As families remain the main stakeholders of LTCFs, this study’s findings could inform policy makers and frontline managers to better shape programs and initiatives to prevent or reduce SIL in LTCFs. International Registered Report Identifier (IRRID) RR2-10.2196/36269
A liposomal radionanoformulation for targeted drug delivery and real time monitoring by radionuclide imaging for HER2 overexpressing cancers

Liposomal formulations carrying chemotherapeutic drugs have demonstrated great potential as effective drug delivery systems. Smart nanoformulations decorated with targeting agents and probes are desired for site specific delivery of drugs and real time monitoring. In this study, we aimed to develop liposomal formulation loaded with doxorubicin and tagged with trastuzumab antibody (Ab) for targeting human epidermal growth factor receptor 2 (HER2) positive tumors. Liposomes were prepared by ethanol injection method using modified lipids to conjugate trastuzumab and radiolabel with Tc‐99m radioisotope using DTPA for imaging by single photon emission computed tomography (SPECT). Doxorubicin was loaded using the active pH gradient method. The conjugation of Ab to liposomes was validated by SDS‐PAGE and MALDI‐MS. 99mTc labeled liposomes encapsulating doxorubicin conjugated with antibody (99mTc‐Lip‐Ab‐Dox) and 99mTc labeled liposomes encapsulating doxorubicin (99mTc‐Lip‐Dox) were found to be stable in blood plasma and saline using chromatography method. The specificity of 99mTc‐Lip‐Ab‐Dox against HER2 receptor was evident from cell uptake and inhibition studies. Results also corroborated with confocal microscopy studies. In vivo studies in tumor bearing severe combined immunodeficient mice by SPECT imaging and biodistribution studies revealed higher uptake of 99mTc‐Lip‐Ab‐Dox in tumor and less accumulation in the liver compared to 99mTc‐Lip‐Dox. In conclusion, liposomal nanoformulation for immunotargeting and monitoring of drug delivery was successfully formulated and evaluated. Encouraging results in preclinical studies were obtained with the radioformulation. Such smart radioformulations will not only serve the purpose of site‐specific controlled release of drugs at the target site but also aid in optimizing the drug doses and schedule of cancer treatment by monitoring pharmacokinetics.
Effects of machine perfusion strategies on different donor types in liver transplantation: a systematic review and meta-analysis

Background: The increasing use of extended criteria donors (ECD) sets higher requirements for graft preservation. Machine perfusion (MP) improves orthotopic liver transplantation (OLT) outcomes, but its effects on different donor types remains unclear. The authors’ aim was to assess the effects of hypothermic machine perfusion (HMP), normothermic machine perfusion (NMP), or normothermic regional perfusion (NRP) versus static cold storage (SCS) on different donor types. Materials and methods: A literature search comparing the efficacy of MP versus SCS in PubMed, Cochrane, and EMBASE database was conducted. A meta-analysis was performed to obtain pooled effects of MP on ECD, donation after circulatory death (DCD), and donor after brainstem death. Results: Thirty nine studies were included (nine randomized controlled trials and 30 cohort studies). Compared with SCS, HMP significantly reduced the risk of non-anastomotic biliary stricture (NAS) [odds ratio (OR) 0.43, 95% confidence interval (CI) 0.26–0.72], major complications (OR 0.55, 95% CI 0.39–0.78), and early allograft dysfunction (EAD) (OR 0.46, 95% CI 0.32–0.65) and improved 1-year graft survival (OR 2.36, 95% CI 1.55–3.62) in ECD-OLT. HMP also reduced primary non-function (PNF) (OR 0.40, 95% CI 0.18–0.92) and acute rejection (OR 0.62, 95% CI 0.40–0.97). NMP only reduced major complications in ECD-OLT (OR 0.56, 95% CI 0.34–0.94), without favorable effects on other complications and survival. NRP lowered the overall risk of NAS (OR 0.27, 95% CI 0.11–0.68), PNF (OR 0.43, 95% CI 0.22–0.85), and EAD (OR 0.58, 95% CI 0.42–0.80) and meanwhile improved 1-year graft survival (OR 2.40, 95% CI 1.65–3.49) in control DCD-OLT. Conclusions: HMP might currently be considered for marginal livers as it comprehensively improves ECD-OLT outcomes. NMP assists some outcomes in ECD-OLT, but more evidence regarding NMP-ECD is warranted. NRP significantly improves DCD-OLT outcomes and is recommended where longer non-touch periods exist.
Report on Post Tsunami Survey along the Myanmar Coast for the December 2004 Sumatra-Andaman Earthquake

Kenji Satake (Active Fault Research Center, GSJ/AIST) Than Tin Aung (Research Center for Deep Geological Environments, GSJ/AIST) Yuki Sawai (Active Fault Research Center, GSJ/AIST) Yukinobu Okamura (Active Fault Research Center, GSJ/AIST) Kyaw Soe Win (Nagoya University) Win Swe (Myanmar Geoscience Society) Chit Swe (Yangon Technological University) Tint Lwin Swe (Yangon Technological University) Soe Thura Tun (Yangon University) Maung Maung Soe (Department of Meteorology and Hydrology) Thant Zin Oo (Department of Meteorology and Hydrology) Saw Htwe Zaw (Myanmar Engineering Society)
Efficacy and associated neurotransmitters of digital cognitive behavior therapy for atopic dermatitis: A comparative effectiveness research.

BACKGROUND Negative emotions are a major comorbidity of atopic dermatitis (AD). Evidence that supports the effectiveness of digital cognitive behavioral therapy (dCBT) as an adjuvant therapy for AD remains limited. OBJECTIVE To investigate the preliminary efficacy of additional dCBT and potential neurotransmitter biomarkers for AD accompanied by negative emotions. METHODS Thirty-two patients with AD were recruited and examined for clinical severity and negative emotions including insomnia, anxiety, and depression. Patients with mild-to-moderate negative emotions were divided into two groups that received standard care (N = 9) or mobile app-delivered CBT plus standard care (N = 11) for 12 weeks. Plasma levels of 40 neurotransmitters were determined using liquid chromatography tandem mass spectrometry pre- and post-treatment. RESULTS Skin lesions, itch, and insomnia were significantly improved in both treatment groups. Improvements of itch (P = 0.0449) and insomnia (P = 0.0089) were more robust in the combination treatment group than those in the standard treatment group. Neurotransmitters that involve tryptophan, dopamine, and histidine pathways were markedly altered in patients with AD compared with healthy controls. Taurine levels were selectively increased following dCBT plus standard care (P = 0.0259). Baseline levels of L-tyrosine were negatively correlated with the reduction of skin lesions (r = -0.9073, P = 0.0334) and itch intensity (r = -0.9322, P = 0.0210) in the combination therapy group. CONCLUSIONS dCBT provides an efficacious supplementary approach for AD accompanied by negative emotions. Emotion-related neurotransmitters may contribute to AD and serve as indicators for treatment effects.
Invited Editorial Comment

1. Sebastien Page 1. is an executive vice president and Head of Client Analytics at PIMCO in Newport Beach, CA . 2. Mark A. Taborsky 1. is an executive vice president and portfolio manager at PIMCO in Newport Beach, CA . > The word ‘risk’ derives from the early Italian risicare,
Stereochemically Active Lone Pair Induced Polar Tri-layered Perovskite for Record-Performance Polarized Photodetection.

Bulk photovoltaic effect, a promising optoelectronic phenomenon for generating polarized dependent steady-state photocurrent, has been widely applied in various photodetectors. However, incorporating stereochemically active lone pairs to construct bulk photovoltage in organic-inorganic hybrid perovskite (OIHP) is still elusive and challenging. Herein, bulk photovoltage (1.2 V) has been successfully achieved by introducing the stereo-chemically active lone pairs perovskitizer to construct a polar tri-layered hybrid perovskite, namely, (IBA)2MHy2Pb3Br10 (1, IBA= iso-butylamine, MHy = methylhydrazine). Strikingly, owning to the promising bulk photovoltage, 1-based detectors exhibit an ultra-highly sensitive polarized photodetection (polarization ratio of up to 24.6) under self-powered mode. This ratio surpasses all the reported 2D OIHP single-crystal photodetectors. In addition, detectors exhibit outstanding responsivity (~ 200 mA·W-1) and detectivity (~ 2.4 × 1013 Jones). More excitingly, further investigation confirms that lone pair electrons in MHy result in the separation of positive and negative charges to produce directional dipoles, which further directional alignment to generate bulk photovoltage, thereby resulting in polarization-dependent photocurrent. Our findings provide a new demonstration for polar multilayer materials' construction and may open opportunities for a host of high-sensitive polarized photodetection.
Environmental microbes promote phenotypic plasticity in reproduction and sleep behaviour

The microbiome has been hypothesized as a driving force of phenotypic variation in host organisms that is capable of extending metabolic processes, altering development and in some cases, conferring novel functions that are critical for survival. Only a few studies have directly shown a causal role for the environmental microbiome in altering host phenotypic features. To assess the extent to which environmental microbes induce variation in host life‐history traits and behaviour, we inoculated axenic Drosophila melanogaster with microbes isolated from drosophilid populations collected from two different field sites and generated two populations with distinct bacterial and fungal profiles. We show that microbes isolated from environmental sites with modest abiotic differences induce large variation in host reproduction, fatty acid levels, stress tolerance and sleep behaviour. Importantly, clearing microbes from each experimental population removed the phenotypic differences. The results support the causal role of environmental microbes as drivers of host phenotypic plasticity and potentially, rapid adaptation and evolution.