Miracle-dz/UniFAR-FTUs huggingface dataset:
A Tandem Duplicate of Anti-Müllerian Hormone with a Missense SNP on the Y Chromosome Is Essential for Male Sex Determination in Nile Tilapia, Oreochromis niloticus

Variation in the TGF-β signaling pathway is emerging as an important mechanism by which gonadal sex determination is controlled in teleosts. Here we show that amhy, a Y-specific duplicate of the anti-Müllerian hormone (amh) gene, induces male sex determination in Nile tilapia. amhy is a tandem duplicate located immediately downstream of amhΔ-y on the Y chromosome. The coding sequence of amhy was identical to the X-linked amh (amh) except a missense SNP (C/T) which changes an amino acid (Ser/Leu92) in the N-terminal region. amhy lacks 5608 bp of promoter sequence that is found in the X-linked amh homolog. The amhΔ-y contains several insertions and deletions in the promoter region, and even a 5 bp insertion in exonVI that results in a premature stop codon and thus a truncated protein product lacking the TGF-β binding domain. Both amhy and amhΔ-y expression is restricted to XY gonads from 5 days after hatching (dah) onwards. CRISPR/Cas9 knockout of amhy in XY fish resulted in male to female sex reversal, while mutation of amhΔ-y alone could not. In contrast, overexpression of Amhy in XX fish, using a fosmid transgene that carries the amhy/amhΔ-y haplotype or a vector containing amhy ORF under the control of CMV promoter, resulted in female to male sex reversal, while overexpression of AmhΔ-y alone in XX fish could not. Knockout of the anti-Müllerian hormone receptor type II (amhrII) in XY fish also resulted in 100% complete male to female sex reversal. Taken together, these results strongly suggest that the duplicated amhy with a missense SNP is the candidate sex determining gene and amhy/amhrII signal is essential for male sex determination in Nile tilapia. These findings highlight the conserved roles of TGF-β signaling pathway in fish sex determination.
Strengthening Evaluation Research: A Case Study of an Evaluability Assessment Conducted in a Carceral Setting

Over the last decade, criminal justice scholars have increasingly endorsed “evidence-based practices”; however, some criminologists have voiced concerns over the varied methodological rigor used by evaluation researchers, differing definitions of evidence, and lack of critical exploration as to why programs may be (in)effective. This article argues that evaluability assessments (EAs) can answer these concerns. Through a case study of an EA used on a prison-based fatherhood program, this article demonstrates how EA’s approach leads to a more precise understanding of outcome operationalization, and allows for the democratization of research, which is particularly important in a carceral setting.
HISTOPATHOLOGICAL CHANGES OF KIDNEY OF BROILER CHICKEN EXPOSED TO CHRONIC HEAT STRESS

The aim of this research was to know histopathological changes of kidney of broiler chicken exposed to chronic heat stress. Twenty broilers were divided randomly into 2 groups, 10 broilers each are being exposed to chronic heat stress for 21 days. The first 21 days were the adaptation period in a chamber with temperature 24-28°C and humidity 40-55%. After 21 days, continue with exposure to heat stress in a chamber with temperature 36-40°C and humidity 50- 65% in 8 hours per day. After exposed to chronic heat stress, kidney tissues were processed, and kidney tissue histopathological changes were evaluated by using the Klopfleisch modified scoring method. The data was analyzed by Mann – Whitney Test. The results of this research showed that chronic heat stress exposure causing the presence of degeneration of tubular epithelial cell, necrosis of tubular epithelial cell, necrosis of glomerular and interstitial infiltration. From the analysis data the overview of multiparametric showed that when control group compared with the treatment group showed significantly difference (p<0.05).
Performance Bound for Blind Extraction of Non-gaussian Complex-valued Vector Component from Gaussian Background

Independent Vector Extraction aims at the joint blind source extraction of K dependent signals of interest (SOI) from K mixtures (one signal from one mixture). Similarly to Independent Component/Vector Analysis (ICA/IVA), the SOIs are assumed to be independent of the other signals in the mixture. Compared to IVA, the (de-)mixing IVE model is reduced in the number of parameters for the extraction problem. The SOIs are assumed to be non-Gaussian or noncircular Gaussian, while the other signals are modeled as circular Gaussian. In this paper, a Cramér-Rao-Induced Bound (CRIB) for the achievable Interference-to-Signal Ratio (ISR) is derived for IVE. The bound is compared with similar bounds for ICA, IVA, and Independent Component Extraction (ICE). Numerical simulations show a good correspondence between the empirical results and the theory.
Weaver Syndrome and EZH2-Related Overgrowth Syndromes

Comprehensive details on Weaver syndrome, one of the best recognized of the overgrowth syndromes, are presented in this chapter. The syndrome is characterized by overgrowth of prenatal onset, a distinctive craniofacial appearance, camptodactyly, widened metaphysis, accelerated bone age, and developmental delay. Like other overgrowth syndromes, Weaver syndrome is accompanied by an increased risk of malignancies, neuroblastoma, leukemia, and lymphoma in particular. The diagnosis relied on clinical evaluation alone until 2012 when the causative gene, EZH2, was discovered. The gene product joins with other related proteins to form a polycomb repressive complex that functions as an epigenetic signal that compacts chromatin and silences genes by histone modifications.
Tissue Bulking Agent-Polyacrylate Polyalcohol Copolymer for Endoscopic Correction of Vesicoureteral Reflux in Children: A Comparative Study

Objective: To evaluate the treatment outcome of single session endoscopic treatment using Polyacrylate Polyalcohol Copolymer (PPC) (Vantris ®) compared with conservative Continuous Antibiotic Prophylaxis (CAP) and open surgical treatment among children with Vesico-Ureteral Reflux (VUR). Methods: A retrospective cohort was undertaken in a single institution to evaluate children diagnosed with primary VUR grade 2-4 from 2006-2012 treated by a single urologist with different treatment modalities- conservative continuous antibiotic prophylaxis, endoscopic correction with PPC and open ureteral re-implantation with Cohen technique. Included patients for the study were only those who had 1-3 months and >1 year post-treatment follow- up study with Voiding Cystourethrogram (VCUG), kidney ultrasound, Dimercaptosuccinic Acid (DMSA) renal scan, and urine culture. Comparative analysis was made to evaluate the rate of VUR resolution, reflux recurrence, renal scaring and VUR treatment related hospital stay. Results: Twenty-five children (12 girl and 13 boys) with a mean age of 3 ± 1.4 years were included. Twelve children had bilateral VUR and thirteen had unilateral VUR, a total of thirty-seven Refluxing Renal Units (RRU) were being analyzed (12 CAP, 11 endoscopic corrections and 14 open re-implantation surgery). On initial 3 months post-treatment follow-up, RRU VUR resolution observed for CAP, PPC and open surgery were 33% (4/12), 91% (10/11) and 100% (14/14), respectively. At >1 year post treatment follow-up, VUR resolution were noted in 50% (6/12) treated with CAP. For PPC treated group, 27% (3/11) had reflux recurrence or persistence and 14% (2/14) of open surgery group had ureteral obstruction with hydronephrosis. Renal scarring detected among CAP, PPC and surgery group at >1 year follow-up were 42% (5/12), 18% (2/11) and 14% (2/14), respectively. VUR treatment related mean hospital day per year was highest among the CAP group (6.25 ± 2.6 days/year) and lowest among PPC group (3.27 ± 1.2 days/year). Conclusion: Endoscopic correction of VUR with PPC resulted to better treatment outcome when compared to CAP and was comparable to open surgical management with shorter treatment related hospital stay.
MEMS based soft nervous materials with ambient RF power supply: Feasibility study

The purpose of this study is to investigate ways to supply low power to MEMS sensors and actuators that can be embedded inside host materials and membranes without adding more physical devices inside the material. These host materials can be low cost polymers, nylon and any other type of plastic composite laminates. Such type of materials that can be used in various engineering applications especially in bioengineering where the device is embedded inside human body. With battery less devices, wireless RF power harvesting seems to be the unique ideal source for low power. The study shows feasibility and identify practices.
Exceedance of heat index thresholds for 15 regions under a warming climate using the wet‐bulb globe temperature

Thermal comfort is quantified in 15 regions using the wet‐bulb globe temperature (WBGT), examining past and future rates of thresholds exceedance corresponding to moderate, high, and extreme heat (28, 32, and 35 °C, respectively). As recent changes to thermal comfort appear to be dominated by temperature and humidity, a WBGT approximation based only on these is used. A new homogenised dataset from 1973 to 2003 is developed which provides WBGT daily means, daily maximums averaged over 5‐day periods, and the highest extreme for each 5‐day period; recent trends are positive for all regions except northeast USA and northeast Australia. A simple model for predicting summertime threshold exceedance rates, with a fixed distribution of anomalies about the seasonal mean, is found to adequately predict changes for the above quantities given seasonal mean values. This model is used to predict the impact of regional 1–5 °C temperature increases on WBGT exceedance rates with no change in relative humidity. Results show that heat events may worsen as much, or more, in humid tropical and mid‐latitude regions even if they warm less than the global average, due to greater absolute humidity increases. A further 2 °C warming from the present is sufficient to push peak WBGT above 35 °C, an extreme heat event, in all regions except the UK.
Immunoprophylaxis with Basiliximab Compared with Antithymocyte Globulin in Renal Transplant Patients Receiving MMF‐containing Triple Therapy

Acute graft rejection remains a major problem in renal transplant recipients, and there is no consensus on the optimal immunosuppressive strategy. Immunoprophylaxis with Thymoglobulin® or basiliximab has significantly reduced the incidence of acute rejection episodes and graft loss following kidney transplantation. This open, randomized, multicenter study investigated the efficacy and tolerability of basiliximab (20 mg day 0– day 4) plus early cyclosporine from day 0 (n = 50) compared with Thymoglobulin® plus delayed cyclosporine (n = 50) in adult kidney transplant patients. In addition, all patients received steroids and mycophenolate mofetil (MMF) at standard doses from day 0. Patient and graft survival rates at 12 months were 98 and 94% in the basiliximab group, respectively, compared with 100 and 96% in the Thymoglobulin® group. The incidences of biopsy‐confirmed acute rejection (8.0% in each group) and treatment failure (14% in the basiliximab group vs. 8% in the Thymoglobulin group) were comparable in the two groups. There was a nonsignificant tendency to more dialysis (14 vs. 6%), and fewer cytomegalovirus (CMV) infections (p = 0.005) in the basiliximab group, but the percentage of clinical CMV was not different between the two groups (6 vs. 12%). Both strategies give excellent results, despite the differences in patterns, in nonhyperimmunized patients receiving their first cadaveric renal allograft.
Polynomial-time membership comparable sets

The paper introduces and studies a notion called polynomial-time membership comparable sets, which is a generalization of P-selective sets. For a function g, a set A is called polynomial-time g-membership comparable if there is a polynomial-time computable function f such that for any x/sub 1/,. ,x/sub m/ with m/spl ges/g(max{|x/sub 1/|,.,|x/sub m/|}), outputs b/spl isin/{0,1}/sup m/ such that (A(x/sub 1/),. A(x/sub m/))/spl ne/b. It is shown for each C chosen from {PSPACE, UP, FewP, NP, C=P, PP, MOD/sub 2/P, MOD/sub 3/P,. }, that if all of C are polynomial-time c(log n)-membership comparable for some fixed constant c<1, then C=P. As a corollary, it is shown that if there is same constant c<1 such that all of C are polynomial-time n/sup c/-truth-table reducible to some P-selective sets, then C=P, which resolves a question that has been left open for a long time. <<ETX>>
Bacteriocins BaCf3 and BpSl14 with anticancer and antibiofilm potential from probiotic Bacillus amyloliquefaciens BTSS3 and Bacillus pumilus SDG14 isolated from gut of marine fishes: Enhanced production, Purification and Characterization

The bacterial isolates from Centroscyllium fabricii (deep sea shark) gut were screened for antagonistic activity by cross-streak method and disc diffusion assay. This study focuses on strain BTSS-3, which showed antimicrobial activity against pathogenic bacteria including Salmonella Typhimurium, Proteus vulgaris, Clostridium perfringens, Staphylococcus aureus, Bacillus cereus, Bacillus circulans, Bacillus macerans and Bacillus pumilus. BTSS3 was subjected to phenotypic characterization using biochemical tests, SEM imaging, exoenzyme profiling and antibiotic susceptibility tests. Comparative 16S rDNA gene sequence analysis indicated that this strain belonged to the genus Bacillus, with high (98 %) similarity to 16S rDNA sequences of Bacillus amyloliquefaciens. The chemical nature of the antibacterial substance was identified by treatment with proteolytic enzymes. The antibacterial activity was reduced by the action of these enzymes pointing out its peptide nature. It was observed from the growth and production kinetics that the bacteriocin was produced in the eighth hour of incubation, i.e., during the mid-log growth phase of the bacteria.
Automated and accurate cache behavior analysis for codes with irregular access patterns

The memory hierarchy plays an essential role in the performance of current computers, so good analysis tools that help in predicting and understanding its behavior are required. Analytical modeling is the ideal base for such tools if its traditional limitations in accuracy and scope of application can be overcome. While there has been extensive research on the modeling of codes with regular access patterns, less attention has been paid to codes with irregular patterns due to the increased difficulty in analyzing them. Nevertheless, many important applications exhibit this kind of pattern, and their lack of locality make them more cache‐demanding, which makes their study more relevant. The focus of this paper is the automation of the Probabilistic Miss Equations (PME) model, an analytical model of the cache behavior that provides fast and accurate predictions for codes with irregular access patterns. The information requirements of the PME model are defined and its integration in the XARK compiler, a research compiler oriented to automatic kernel recognition in scientific codes, is described. We show how to exploit the powerful information‐gathering capabilities provided by this compiler to allow the automated modeling of loop‐oriented scientific codes. Experimental results that validate the correctness of the automated PME model are also presented. Copyright © 2007 John Wiley & Sons, Ltd.
Impact of Haemophilus influenzae Type B Conjugate Vaccines on Nasopharyngeal Carriage in HIV-infected Children and Their Parents From West Bengal, India.

BACKGROUND In addition to reducing Haemophilus influenzae type b (Hib) disease in vaccinated individuals, the Hib conjugate vaccine (HibCV) has indirect effects; it reduces Hib disease in unvaccinated individuals by decreasing carriage. Human immunodeficiency virus (HIV)-infected children are at increased risk for Hib disease and live in families where multiple members may have HIV. The aim of this study is to look at the impact of 2 doses of the HibCV on nasopharyngeal carriage of Hib in HIV-infected Indian children (2-15 years) and the indirect impact on carriage in their parents. METHODS This prospective cohort study was conducted in HIV-infected and HIV-uninfected families. Nasopharyngeal swabs were collected from children and parents before and after vaccination. HIV-infected children 2-15 years of age got two doses of HibCV and were followed up for 20 months. Uninfected children 2-5 years of age got 1 dose of HibCV as catch-up. RESULTS 123 HIV-infected and 44 HIV-uninfected children participated. Baseline colonization in HIV-infected children was 13.8% and dropped to 1.8% (P = 0.002) at 20 months. Baseline carriage in HIV-uninfected children was 4.5% and dropped to 2.3% after vaccination (P = 0.3). HIV-infected parents had 12.3 times increased risk of Hib carriage if their child was colonized (P = 0.04) and had 9.3 times increased risk if their child had persistent colonization postvaccine (P = 0.05). No parent of HIV-uninfected children had Hib colonization at any point. Pneumococcal colonization was associated with increased Hib colonization. CONCLUSION Making the HibCV available to HIV-infected children could interrupt Hib carriage in high-risk families.
Kinetics and Equilibrium of Crude Oil Sorption from Aqueous Solution Using Borassus Aeothopum Coir

In this study, Borassus aethopum coir (BAC) which is an abundant, cheap, readily available and biodegradable agricultural waste was modified by acetylation using acetic anhydride and NBS catalyst at room temperature. This was to increase their hydrophobic properties and improve their sorption capacity in aqueous environment. The crude oil sorption kinetic data were fitted by intra-particle diffusion and pseudo-first order for raw BAC but the pseudo-second order kinetic model best fits crude oil sorption data for acetylated BAC. The Langmuir and Freundlich models were used to elucidate the sorption behaviour of crude oil with raw and acetylated BAC. Freundlich isotherm gave the best fit for the equilibrium crude oil sorption data for acetylated BAC and raw BAC. Fourier transform infrared and scanning electron microscope analyses showed clear evidence of successful acetylation. The results presented and discussed in the study suggests that acetylated BAC (ABAC) is more suitable for crude oil sorption than raw BAC, therefore, possesses more potential for application and further development in treatment of oil spillage. Keywords : acetylated borassus aethopum coir, kinetics, crude oil sorption, sorbents, sorption capacity. DOI : 10.7176/CMR/11-2-02
On dimensional reductions of the M-9-brane

We discuss the relations of the M-9-brane with other branes via dimensional reductions, mainly focusing on their Wess-Zumino (WZ) actions. It is shown that on three kinds of dimensional reductions, the WZ action of the M-9-brane respectively gives those of the D-8-brane, the “KK-8A brane” (which we regard as a kind of D-8-brane) and the “NS-9A brane”, the last two actions of which were obtained via dualities. Based on these results, we conclude that the relation of p-branes for p ≥ 8, proposed previously, is consistent from the viewpoint of worldvolume actions.
D ec 2 00 4 The existence of maximum likelihood estimates in the Bradley-Terry model and its extensions

In the Bradley-Terry model for paired comparisons, and its extensions to include order effects and ties, the maximum likelihood estimates of probabilities of certain outcomes can be 0 or 1 under certain data configurations. This poses problems for standard estimation methods. In this paper, we give algorithms for identifying the outcomes with estimated probability 0 or 1, and indicate how the remaining probabilities may be estimated and summarized.
The Use of the Instantaneous-Reactive-Power Signature Analysis for Rotor-Cage-Fault Diagnostics in Three-Phase Induction Motors

In this paper, a new detection technique based on the instantaneous-reactive-power signature analysis is proposed for the diagnosis of rotor-cage faults (RCFs) in operating three-phase induction motors (IMs). This technique has been tested through the simulation of two different IMs using a mathematical model based on the winding-function approach. In order to demonstrate the capability of the proposed tool for rotor-condition monitoring, these simulations are complemented by the experimental results obtained from two IMs with several faulty rotors, powered from sinusoidal and nonsinusoidal supply voltages. The results obtained by the fast-Fourier-transform algorithm and the Welch method show the merits of the proposed approach for the detection of RCFs. A suitable fault-severity factor is also proposed as an indicator of the motor condition. Moreover, the inductive reactive effect of RCFs is underlined to demonstrate the effectiveness and convenience of this new technique for the diagnosis of RCFs in three-phase IMs.
An JPEG Information Hiding Algorithm of Resisting FR

FR is a steganalysis algorithm based on frequency domain for F5. It has been widely used because of its high-capacity and robustness. In recent years, many scholars have engaged in the field. In this paper, It is proposed for a JPEG information hiding algorithm of resisting F5(JHRF). By embedding secret information into IPEG image by rules, JHRF can deal effectively with abnormal data and get better results resisting FR. The experiment results show that JHRF is more effective.
The Jarisch-Herxheimer Reaction in Leptospirosis: A Systematic Review

Background Leptospirosis is an endemo-epidemic zoonotic disease associated with potentially fatal renal, cardiovascular or pulmonary failure. Recommended treatment includes antibiotics, which may induce a Jarisch-Herxheimer reaction (JHR). Since little information on the importance of this adverse event is available, we performed this review to quantify frequency and impact of JHR in leptospirosis management. Methodology/Principal Findings This review systematically summarizes the literature on the JHR in leptospirosis. To approach the broader aspects of the subject, articles considering the treatment of leptospirosis, national leptospirosis guidelines and textbook and technical reports of the World Health Organisation were reviewed. Publications describing JHR in leptospirosis are very limited and consist mainly of single case reports and small case series. A single randomized control trial specifically assessed the JHR occurrence, but it has never been systematically investigated in large trials. Not all guidelines and not all literature on leptospirosis mention this reaction which can be fatal. Conclusions/Significance Although generally assumed to be a rare event, the true prevalence of JHR in leptospirosis is unknown and the awareness of this event is insufficient. All leptospirosis guidelines and local leptospirosis protocols should stress on systematic monitoring for clinical status early after antibiotic administration. Large well designed studies are required to precise the incidence and the impact of JHR as well as the severity and rates between various antibiotics.