Miracle-dz/UniFAR-FTUs huggingface dataset:
New and updated stellar parameters for 90 transit hosts - The effect of the surface gravity

Context. Precise stellar parameters are crucial in exoplanet research for correctly determining the planetary parameters. For stars hosting a transiting planet, determining the planetary mass and radius depends on the stellar mass and radius, which in turn depend on the atmospheric stellar parameters. Different methods can provide different results, which leads to different planet characteristics. Aims. In this paper, we use a uniform method to spectroscopically derive stellar atmospheric parameters, chemical abundances, stellar masses, and stellar radii for a sample of 90 transit hosts. Surface gravities are also derived photometrically using the stellar density as derived from the light curve. We study the effect of using these different surface gravities on the determination of the chemical abundances and the stellar mass and radius. Methods. A spectroscopic analysis based on Kurucz models in local thermodynamical equilibrium was performed through the MOOG code to derive the atmospheric parameters and the chemical abundances. The photometric surface gravity was determined through isochrone fitting and the use of the stellar density, directly determined from the light curve. Stellar masses and radii are determined through calibration formulae. Results. Spectroscopic and photometric surface gravities differ, but this has very little effect on the precise determination of the stellar mass in our spectroscopic analysis. The stellar radius, and hence the planetary radius, is most affected by the surface gravity discrepancies. For the chemical abundances, the difference is, as expected, only noticable for the abundances derived from analyzing lines of ionized species.
Non-stationary Transformers: Exploring the Stationarity in Time Series Forecasting

Transformers have shown great power in time series forecasting due to their global-range modeling ability. However, their performance can degenerate terribly on non-stationary real-world data in which the joint distribution changes over time. Previous studies primarily adopt stationarization to attenuate the non-stationarity of original series for better predictability. But the stationarized series deprived of inherent non-stationarity can be less instructive for real-world bursty events forecasting. This problem, termed over-stationarization in this paper, leads Transformers to generate indistinguishable temporal attentions for different series and impedes the predictive capability of deep models. To tackle the dilemma between series predictability and model capability, we propose Non-stationary Transformers as a generic framework with two interdependent modules: Series Stationarization and De-stationary Attention. Concretely, Series Stationarization unifies the statistics of each input and converts the output with restored statistics for better predictability. To address the over-stationarization problem, De-stationary Attention is devised to recover the intrinsic non-stationary information into temporal dependencies by approximating distinguishable attentions learned from raw series. Our Non-stationary Transformers framework consistently boosts mainstream Transformers by a large margin, which reduces MSE by 49.43% on Transformer, 47.34% on Informer, and 46.89% on Reformer, making them the state-of-the-art in time series forecasting. Code is available at this repository: https://github.com/thuml/Nonstationary_Transformers.
Towards a Law of Invariance in Human Concept Learning

Invariance principles underlie many key theories in modern science. They provide the explanatory and predictive framework necessary for the rigorous study of natural phenomena ranging from the structure of crystals, to magnetism, to relativistic mechanics. Vigo (2008, 2009)introduced a new general notion and principle of invariance from which two parameter-free (ratio and exponential) models were derived to account for human conceptual behavior. Here we introduce a new parameterized exponential “law” based on the same invariance principle. The law accurately predicts the subjective degree of difficulty that humans experience when learning different types of concepts. In addition, it precisely fits the data from a large-scale experiment which examined a total of 84 category structures across 10 category families (R-Squared =.97, p < .0001; r= .98, p < .0001). Moreover, it overcomes seven key challenges that had, hitherto, been grave obstacles for theories of concept learning.
Pediatric endoscopy training across Europe: a survey of the ESPGHAN National Societies Network 2016–2019

Background and study aims The ability to perform endoscopy procedures safely and effectively is a key aspect of quality clinical care in Pediatric Gastroenterology, Hepatology and Nutrition (PGHN). The aim of this survey, which was part of a global survey on PGHN training in Europe, was to assess endoscopy training opportunities provided across Europe. Methods Responses to standardized questions related to endoscopy training were collected from training centers across Europe through the presidents/representatives of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition National Societies from June 2016 to December 2019. Results A total of 100 training centers from 19 countries participated in the survey. In 57 centers, the endoscopy suit was attached to the PGHN center, while in 23, pediatric endoscopies were performed in adult endoscopy facilities. Ninety percent of centers reported the availability of specialized endoscopy nurses and 96 % of pediatric anesthetists. Pediatric endoscopies were performed by PGHN specialists in 55 centers, while 31 centers reported the involvement of an adult endoscopist and 14 of a pediatric surgeon. Dividing the number of procedures performed at the training center by the number of trainees, ≤ 20 upper, lower, or therapeutic endoscopies per trainee per year were reported by 0 %, 23 %, and 56 % of centers, respectively, whereas ≤ 5 wireless capsule endoscopies per trainee per year by 75 %. Only one country (United Kingdom) required separate certification of competency in endoscopy. Conclusions Differences and deficiencies in infrastructure, staffing, and procedural volume, as well as in endoscopy competency assessment and certification, were identified among European PGHN training centers limiting training opportunities in pediatric endoscopy.
Association of Physical Activity with Retinal Thickness and Vascular Structure in Elderly Chinese Population

Introduction: We aimed to assess the association of physical activity (PA) with retinal thickness and vascular structure in an elderly Chinese population. Methods: This study enrolled 220 retirees aged 50 years and above from Tianjin University of Sport, China. PA data gathered through the International Physical Activity Questionnaires were computed for metabolic equivalent of task-minutes per week. All participants underwent full ophthalmic examination including optical coherence tomography angiography. Multiple linear regression analyses were used to evaluate the association of PA with retinal thickness and vascular structure. Results: A high amount of total PA was associated with smaller size of foveal avascular zone (FAZ) (high vs. low: area, β = −0.04; circumference β = −0.14) and greater central vessel density (VD) (β = 1.04) and perfusion density (PD) (β = 0.02). For domain-specific PA, participants with high and moderate recreational PA levels were found to have greater central VDs and PDs. Nonleisure activities demonstrated negative relationship with FAZ perimeter ratio (moderate vs. low: β = −0.08; high vs. low: β = −0.13) and, counter-intuitively, negative relation with VDs measured at the inner (high vs. low: β = −0.98) and outer retinal layers (high vs. low: β = −0.38). Additionally, higher levels of total PA were related to increased macular fovea thickness and average thickness of retinal nerve fiber layer. Conclusions: High PA level, particularly recreational PA, was associated with smaller FAZ and greater VD and PD in senior adults. Nonleisure-time PA might not confer the same health benefits as leisure-time PA. Our data support a possible protective role of recreational PA in the retina against microvascular changes.
Alignment of the metatarsal heads affects foot inversion/eversion during tiptoe standing on one leg in demi–pointe position: A cross–sectional study on recreational dancers

Classical ballet dancers stand on tiptoe in the demi–pointe position where the ankle is plantarflexed, and the toes extend around a mediolateral axis passing through the second metatarsal head. Foot sickling, the foot inversion/eversion when the forefoot is grounded, should be avoided to achieve esthetics and prevent injuries during tiptoe standing. The foot inversion/eversion angle may change depending on the metatarsal heads through which the toe extension axis passes. This study investigated the relationship between metatarsal alignment in both load positions and foot inversion/eversion angle during tiptoe standing. Nine recreational female ballet dancers performed tiptoe standing on a single leg in the demi–pointe position. The foot inversion/eversion angle, the centre of pressure (COP) positions, and angles between adjacent metatarsal heads in the horizontal plane were investigated using motion–capture data and magnetic resonance imaging of the forefoot. As the angle between the second and adjacent metatarsal heads became more acute during tiptoe standing on the non-dominant leg, the dancers everted the foot more and significantly loaded the first toe–side more, and vice versa (r = −0.85 and −0.82, respectively). Then, the load positions were distributed on the distal side of the second metatarsal head. These were not seen during standing on the dominant leg with COPs more proximal to the second metatarsal head. In conclusion, dancers load the distal part of the second metatarsal head during tiptoe standing on the non–dominant leg. When the angle at the second metatarsal head was acute, within the triangle formed by the first, second, and third metatarsal heads, even slight mediolateral shifts of load positions altered the toe extension axis around that metatarsal head; the dancers loaded medial to the second metatarsal head and everted the foot and vice versa. Therefore, the angle between the second and adjacent metatarsal heads influenced the foot inversion/eversion angle.
Percutaneous cholecystostomy and acute cholecystitis: how, when and why.

AIM Acute cholecystitis (AC) is one of the most frequent pathologies treated in urgency. An immediate surgical intervention for frail patients who are ineligible for surgery as a result of severe co-morbidities is questionable. The aim of this study is to investigate the safety and the management of percutaneous cholecistostomy (PC) in high-risk surgical patients. MATERIALS AND METHODS In the period of time January 2015 - May 2021 we observed 1105 patients admitted with acute cholecystitis in our Department. In the group with severe cholecystitis (160 patients, 14.48%), 137 (12.39%) were submitted to immediate surgery, and 23 (4.8%) were treated with PC. All these patients were non-responding to conservative management. Initially, we used PC as a definitive treatment; from the second half of 2018 PC was implemented as a bridge to surgery. RESULTS Clinically, symptoms resolved in all the 23 patients. Mortality was nihil and no complication was recorded. PC was used as definitive treatment in 14 cases, wheres in 9 patients PC was intended as a-bridge-to-surgery treatment, and was followed by cholecystectomy. DISCUSSION 2017 guidelines, of World Society of Emergency Surgery recommended PC as a safe and effective management of AC in patients with multiple comorbidities. In this group of patients PC achieves a prompt resolution of clinical symptoms and is superior to conservative management. There are no absolute contraindications to PC. CONCLUSIONS PC is a safe and less invasive treatment of AC for patients with prohibitive surgical risk. It may be used as bridge to surgery to switch high-risk for moderate-risk patients, more suitable for a safe and definitive surgical treatment. KEY WORDS Acute cholecystitis, High-risk surgical patients, Percutaneous cholecystostomy.
Nitrogen Fertilizer Application Alters the Root Endophyte Bacterial Microbiome in Maize Plants, but Not in the Stem or Rhizosphere Soil

We investigated the bacterial community structure in the rhizosphere, root, and stem of maize plants cultivated under different agricultural techniques, i.e., with or without N fertilization, and with or without tillage. We found that the bacterial community was defined mostly by the plant compartment and less by agricultural techniques. ABSTRACT Plant-associated microorganisms that affect plant development, their composition, and their functionality are determined by the host, soil conditions, and agricultural practices. How agricultural practices affect the rhizosphere microbiome has been well studied, but less is known about how they might affect plant endophytes. In this study, the metagenomic DNA from the rhizosphere and endophyte communities of root and stem of maize plants was extracted and sequenced with the “diversity arrays technology sequencing,” while the bacterial community and functionality (organized by subsystems from general to specific functions) were investigated in crops cultivated with or without tillage and with or without N fertilizer application. Tillage had a small significant effect on the bacterial community in the rhizosphere, but N fertilizer had a highly significant effect on the roots, but not on the rhizosphere or stem. The relative abundance of many bacterial species was significantly different in the roots and stem of fertilized maize plants, but not in the unfertilized ones. The abundance of N cycle genes was affected by N fertilization application, most accentuated in the roots. How these changes in bacterial composition and N genes composition might affect plant development or crop yields has still to be unraveled. IMPORTANCE We investigated the bacterial community structure in the rhizosphere, root, and stem of maize plants cultivated under different agricultural techniques, i.e., with or without N fertilization, and with or without tillage. We found that the bacterial community was defined mostly by the plant compartment and less by agricultural techniques. In the roots, N fertilizer application affected the bacterial community structure, the microbiome functionality, and the abundance of genes involved in the N cycle, but the effect in the rhizosphere and stem was much smaller. Contrary, tillage did not affect the maize microbiome. This study enriches our knowledge about the plant-microbiome system and how N fertilization application affected it.
Targeted delivery of an anti-inflammatory corticosteroid to Ly6C/G-positive cells abates severity of influenza A symptoms

Significance Viruses that target the respiratory tract can inflict pulmonary damage, with acute respiratory distress syndrome (ARDS) as a potentially fatal outcome. Neutrophils are key actors in ARDS. Here, we use nanobodies that target Ly6C/G, markers of neutrophils, to image inflammation in the lung and to selectively deliver dexamethasone to the targeted cell population via a nanobody-drug conjugate (NDC) in influenza virus–infected mice. The positron emission tomography imaging data show a clear increase of the Ly6C/G-positive population in the lungs during infection. The NDC prevented weight loss in mice, using but a fraction of the amount of free drug that would be required for treatment.
High Energy Astrophysics, 3rd edn., by Malcolm S. Longair

there were 11 invited speakers, 48 oral presentations in the 15 scientific sessions and 72 poster contributions. It is known that the main reservoirs of icy bodies in the solar system are the Oort Cloud, the EdgeworthKuiper Belt (EKB) and the outer asteroid belt. It is also worth noting that these reservoirs also dispense comets. The long-period comets can be associated with the Oort Cloud, the short-period ones with the EKB and the main-belt comets with the outer asteroid belt. This review, by non-specialists, covers discussion on the icy satellites of the outer planets, icy dwarf planets or plutoids and physical processes in comets. The term plutoid, as agreed by the IAU Executive Committee in 2006, refers to dwarf planets. Objects currently known as plutoids are Ceres, Eris, Haumea, Makemake and Pluto. For it to be called a plutoid in the solar system, an object must not have cleared the neighbourhood around its orbit and must have sufficient mass for its self-gravity to overcome rigid body forces so that it assumes a nearly spherical shape. The dynamical and geophysical criteria introduced by the IAU in Resolution B5: Definition of a Planet in the Solar System are discussed in one of the papers. An updated list of plutoid candidates is also given. The paper presents what is called a decision tree to determine whether or not an object is an icy plutoid. Fifteen icy plutoids and possibly nine more have been found. It has also revised their physical and dynamical characteristics and suggested that Sedna, Orcus and Quaoar be officially classified as plutoids. About 40 years ago, scientists hypothesised on the existence of liquid water oceans on planetary icy moons like Europa. With the advent of spacecraft, in-depth studies of their structure and interiors have progressed considerably. The creation of liquid water is thought to be dependent on the moons’ accretion history while its maintenance is closely related to the internal structure of the moons themselves. One paper investigates the existence of habitable liquid water reservoirs and concludes that, among others, it depends on the presence of substances that depress the freezing point of liquid water. It also presents a brief but thorough discussion on the geophysical limitation of the Jovian and Saturnian satellites’ formation. A short paper explaining the 1908 Tunguska explosion is worth reading by curious researchers. Using the characteristics of the nuclei of comets Halley and Shoemaker-Levy 9, along with observational data, the mathematical model confirms that the cosmic body that destroyed the Siberian coniferous forest was basically a comet. The proceedings also discuss transNeptunian objects and review the space missions Deep Impact, New Horizons and Rosetta. To conclude, it provides an excellent start for new PhDs and postdocs who are inclined to start a research on icy bodies in the solar system.
General clinical and methodological considerations on the extrapolation of pharmacokinetics and optimization of study protocols for small molecules and monoclonal antibodies in children

Pharmacometric modelling plays a key role in both the design and analysis of regulatory trials in paediatric drug development. Studies in adults provide a rich source of data to inform the paediatric investigation plans, including knowledge on drug pharmacokinetics (PK), safety and efficacy. In children, drug disposition differs widely from birth to adolescence but extrapolating adult to paediatric PK, safety and efficacy either with pharmacometric or physiologically based approaches can help design or in some cases reduce the need for clinical studies. Aspects to consider when extrapolating PK include the maturation of drug metabolizing enzyme expression, glomerular filtration, drug excretory systems, and the expression and activity of specific transporters in conjunction with other drug properties such as fraction unbound. Knowledge of these can be used to develop extrapolation tools such as allometric scaling plus maturation functions or physiologically based PK. PK/pharmacodynamic approaches and well‐designed clinical trials in children are of key importance in paediatric drug development. In this white paper, state‐of‐the‐art of current methods used for paediatric extrapolation will be discussed. This paper is part of a conect4children implementation of innovative methodologies including pharmacometric and physiologically based PK modelling in clinical trial design/paediatric drug development through dissemination of expertise and expert advice. The suggestions arising from this white paper should define a minimum set of standards in paediatric modelling and contribute to the regulatory science.
Risk Model Development and Validation in Clinical Oncology: Lessons Learned

Abstract Reliable risk models can greatly facilitate patient-centered inferences and decisions. Herein we summarize key considerations related to risk modeling in clinical oncology. Often overlooked challenges include data quality, missing data, effective sample size estimation, and selecting the variables to be included in the risk model. The stability and quality of the model should be carefully interrogated with particular emphasis on rigorous internal validation.
Genome Characteristics of Vardy, a Cluster DJ Actinobacteriophage Isolated on Gordonia rubripertincta in Western North Carolina

Phage Vardy is a lytic siphovirus isolated from creek soil in Cullowhee, NC, using Gordonia rubripertincta NRRL B-16540. Vardy’s 60,144-bp genome contains 90 predicted genes and five copies of a 50-bp motif that may regulate gene expression. Based on gene content similarity, Vardy is assigned to cluster DJ. ABSTRACT Phage Vardy is a lytic siphovirus isolated from creek soil in Cullowhee, NC, using Gordonia rubripertincta NRRL B-16540. Vardy’s 60,144-bp genome contains 90 predicted genes and five copies of a 50-bp motif that may regulate gene expression. Based on gene content similarity, Vardy is assigned to cluster DJ.