Miracle-dz/UniFAR-FTUs huggingface dataset:
Automated Guided Vehicle Systems: a Driver for Increased Business Performance

The automation of transportation in the production, trade and service sector is a key point in the optimization of logistics. Automated Guided Vehicle Systems (AGVS) provide several benefits to fulfill this task. This paper provides an overview on AGVS technology, points out recent technological developments and describes results of research performed by the Department Planning and Controlling of Warehouse and Transport Systems (PSLT) e.g. statistical analyses, characteristic curves and new approaches.
Quality of life in paediatric inflammatory bowel disease measured by a generic and a disease‐specific questionnaire

This study assessed the impact of inflammatory bowel disease (IBD) on the health‐related quality of life (HRQoL) of children and adolescents, using both a generic and a disease‐specific instrument. Three questionnaires were sent to all patients (8–18 y old) from the database of two large secondary/tertiary hospitals in the western part of The Netherlands. In total, 83 (66%) children responded, 18 were between 8 and 12 y old and the remaining 65 were older. HRQoL was measured using a generic instrument, the TNO‐AZL Children's Quality of Life questionnaire (TACQOL), assessing seven domains, and the Impact‐II (NL), a disease‐specific instrument assessing six domains. Disease activity was measured by a five‐item symptom card. Compared with scores from a large reference population (n= 1810), younger children with IBD had a comparable HRQoL (measured by the TACQOL) on six domains, and better cognitive functioning, although they did not have severely active disease. Adolescent patients with IBD had a significantly impaired HRQoL on four domains (body complaints, motor functioning, autonomy and negative emotions). The Impact‐II discriminated well between patients with varying disease activity states on all domains.
The ‘New Working Class’

The problem of the ‘new working class’ is located in the events of recent political history, specifically in the three successive electoral defeats of the Labour Party. In attempting to explain the failure of the traditional working class party to increase, or even retain, its support among the wage-earning population, a good many generalizations about the causes and consequences of secular changes in the class structure have been advanced and disputed. The salient thesis is that which seeks to account for the conservative drift of the working class in terms of their growing prosperity and their gradual assimilation to the middle class in an economy of full employment and rising expectations of material welfare. As one writer puts it: “The whole working class finds itself on the move, moving towards new middle class values and middle class existence” (1).
Family Instability, School Context, and the Academic Careers of Adolescents

An emerging literature suggests that the increasingly complex family histories of American children are linked with multiple domains of adolescent development. Much of this scholarship focuses on associations at the individual level. Here, the authors consider whether key dimensions of the school context, specifically the aggregate level of family instability and the academic press within schools, moderate the link between family instability and young people’s course-taking patterns in mathematics in high school. Using the school-based design and the retrospective reports of family structure in the National Longitudinal Study of Adolescent Health and the linked academic transcript data in the Adolescent Health and Achievement Study (n = 6,545), the authors find that students from unstable families do more poorly when they attend schools with a high proportion of academically oriented students. The prevalence of family instability in a school does not moderate the individual experience of family instability in predicting course-taking patterns.
Commitment and Personality Variables as Discriminators among Sports Referees

In organizational research, commitment has generally been used to predict behaviors such as turnover or absence. Little research has been done with commitment as a potential discriminator between occupations. The present study used commitment in conjunction with personality variables to differentiate between soccer and track and field referees. Data collected from 86 subjects showed that both types of variables individually and in combination significantly discriminate between occupations. In combination, commitment and personality classified more than 81 % of the referees into the correct group. Implications for other areas of research were discussed.
A Single-stranded DNA-binding Protein Is Needed for Efficient Presynaptic Complex Formation by the Saccharomyces cerevisiae Rad51 Protein*

Protein-promoted DNA strand exchange requires formation of an active presynaptic complex between the DNA-pairing protein and single-stranded DNA (ssDNA). Formation of such a contiguous filament is stimulated by a ssDNA-binding protein. Here, the effects of replication protein A (RPA) on presynaptic complex formation and DNA strand exchange activities of Rad51 protein were examined. Presynaptic complex formation was assessed by measuring ATP hydrolysis. With φX174 ssDNA, the ATPase activity of Rad51 protein is stimulated ∼1.4-fold by RPA, provided that Rad51 protein is in excess of the ssDNA concentration; otherwise, RPA inhibits ATPase activity. In contrast, with ssDNA devoid of secondary structure (poly(dT), poly(dA), poly(dI), and etheno-M13 DNA), RPA does not stimulate the already elevated ATPase activity of Rad51 protein, but inhibits activity at low Rad51 protein concentrations. These results suggest that Rad51 protein and RPA exclude one another from ssDNA by competing for the same binding sites and that RPA exerts its effect on presynaptic complex formation by eliminating secondary structure to which Rad51 protein is bound nonproductively. DNA strand exchange catalyzed by Rad51 protein is also greatly stimulated by RPA. The optimal stoichiometry for stimulation is ∼20-30 nucleotides of ssDNA/RPA heterotrimer. The ssDNA-binding protein of Escherichia coli can substitute for RPA, showing that the role of RPA is not specific. We conclude that RPA affects both presynaptic complex formation and DNA strand exchange via changes in DNA structure, employing the same mechanism used by the ssDNA-binding protein to effect change in E. coli RecA protein activity.
Detrimental effects of constant light exposure and high‐fat diet on circadian energy metabolism and insulin sensitivity

Circadian rhythm disturbances are observed in, e.g., aging and neurodegenerative diseases and are associated with an increased incidence of obesity and diabetes. We subjected male C57Bl/6J mice to constant light [12‐h light‐light (LL) cycle] to examine the effects of a disturbed circadian rhythm on energy metabolism and insulin sensitivity. In vivo electrophysiological recordings in the central pacemaker of the suprachiasmatic nuclei (SCN) revealed an immediate reduction in rhythm amplitude, stabilizing at 44% of normal amplitude values after 4 d LL. Food intake was increased (+26%) and energy expenditure decreased (–13%), and we observed immediate body weight gain (d 4: +2.4%, d 14: +5.0%). Mixed model analysis revealed that weight gain developed more rapidly in response to LL as compared to high fat. After 4 wk in LL, the circadian pattern in feeding and energy expenditure was completely lost, despite continuing low‐amplitude rhythms in the SCN and in behavior, whereas weight gain had stabilized. Hyperinsulinemic‐euglycemic clamp analysis revealed complete abolishment of normal circadian variation in insulin sensitivity in LL. In conclusion, a reduction in amplitude of the SCN, to values previously observed in aged mice, is sufficient to induce a complete loss of circadian rhythms in energy metabolism and insulin sensitivity. —Coomans, C. P., van den Berg, S. A. A. , Houben, T. , van Klinken, J.‐B. , van den Berg, R. , Pronk, A. C. M. , Havekes, L. M. , Romijn, J. A. , Willems van Dijk, K. , Biermasz, N. R. , Meijer, J. H. Detrimental effects of constant light exposure and high‐fat diet on circadian energy metabolism and insulin sensitivity. FASEB J. 27, 1721–1732 (2013). www.fasebj. org
Affiliation motivation and interest in entrepreneurial careers

Purpose – The goal of this paper is to better understand affiliation motivation patterns among students interested in pursuing entrepreneurial/self‐employment careers as compared to students less interested in pursuing entrepreneurial careers.Design/methodology/approach – The study sample included 424 college students enrolled in upper‐division business courses in a public institution in the Mid‐Atlantic region of the USA. Structural equation modeling was used to examine the effects of four dimensions of affiliation motivation on entrepreneurial aspirations.Findings – Interest in entrepreneurial careers was negatively associated with the need for emotional support and positively associated with the need for positive stimulation from other persons. Therefore, persons with entrepreneurial interests enjoy interacting with other people, but they are not emotionally dependent upon them. Neither the need for social comparison nor the need for attention varied as a function of entrepreneurial aspirations.Researc.
Quantitative Study of Circadian Variations of Ambulatory Blood Pressure in Chinese Healthy, Hypertensive, and Diabetes Subjects

Ambulatory blood pressure monitoring (ABPM) recorded abundant data of BP and heart rate (HR) variations with even more derived parameters for evaluation of BP. Using our ABP database system established recently, we studied quantitatively the data of 24-hr ABP in Chinese. First, 155 Chinese were divided into three groups: 50 healthy subjects (C) of 20 men and 30 women, aged 60.0 ± 10.3 (SD) years; 58 hypertensive patients (H, mild or moderate hypertension) of 33 men and 25 women, aged 59.4 ± 8.0 years; 47 diabetes patients (D, type 2 diabetes, all were normotensive and with no insulin treatment) with 28 men and 19 women, aged 61.0 ± 8.5 years. Then 24-hr ABP was monitored by TM-2421 Monitor and data were analyzed by ABP database, cosinor method, and conventional statistics. Our results were 4-fold: 1) systolic BP (SBP), diastolic BP (DBP), HR, rate-pressure product (HR × SBP) showed circadian variations, and significant circadian rhythms were confirmed by cosinor method in all groups. MESOR (midline estimate statistic of rhythm) differed significantly among three groups (H had the highest and C had the lowest values); 2) BP means (SBP, DBP, pulse pressure [PP], and HR × SBP) and BP loads (SBP, DBP, and PP) showed significant differences among the groups (H and D had higher values than that of C); 3) there were no significant differences of BP variability (BPV) of SBP, DBP, and PP among the groups; 4) areas under curve of BP (SBP, DBP, and PP) in H were significantly higher than in C and there was no significant difference between H and D. We concluded that ABPM can offer abundant information on BP evaluation by its direct recording data and derived parameters. The computerized way of treating the large numbers of ABPM values supplies a useful tool in evaluation of BP. Our results suggest that clinically normotensive diabetes patients had some pathological alterations in their BP systems.
Cross-Target View to Feature Selection: Identification of Molecular Interaction Features in Ligand-Target Space

There is growing interest in computational chemogenomics, which aims to identify all possible ligands of all target families using in silico prediction models. In particular, kernel methods provide a means of integrating compounds and proteins in a principled manner and enable the exploration of ligand-target binding on a genomic scale. To better understand the link between ligands and targets, it is of fundamental interest to identify molecular interaction features that contribute to prediction of ligand-target binding. To this end, we describe a feature selection approach based on kernel dimensionality reduction (KDR) that works in a ligand-target space defined by kernels. We further propose an efficient algorithm to overcome a computational bottleneck and thereby provide a useful general approach to feature selection for chemogenomics. Our experiment on cytochrome P450 (CYP) enzymes has shown that the algorithm is capable of identifying predictive features, as well as prioritizing features that are indicative of ligand preference for a given target family. We further illustrate its applicability on the mutation data of HIV protease by identifying influential mutated positions within protease variants. These results suggest that our approach has the potential to uncover the molecular basis for ligand selectivity and off-target effects.
Research on Teaching in Physical Education: An Analysis of Published Research.

The purpose of this study was to identify, categorize, and analyze published research on teaching in physical education. (RT-PE). An exhaustive search was performed to identify RT-PE since 1980. Over 2,700 papers were reviewed, and 179 met the criteria for inclusion in the study. Each paper was categorized to obtain detailed information on focus, design, and publication outlet. The results indicated that most RT-PE focused on teacher effectiveness and was quantitative. While much of the research met the minimum demands of good research in the area, some research clearly could be improved. In addition, the Journal of Teaching Physical Education was the major outlet for the research and various other trends were found about publication outlets.
Employing Multilevel Intersectionality in Educational Research

The theoretical framework of intersectionality shows much promise in exploring how multiple social identities and their relationships with interlocking systems of power influence educational equity, particularly for historically underserved groups in education. Yet, social scientists have critiqued this framework for not adequately specifying how these dimensions shape life opportunities. This essay draws on the work of sociologist Floya Anthias to advance a conceptual model of intersectionality for educational research. This model addresses how different levels of analysis, types of practices, and relationships between social categories separately or together affect educational opportunities. To illustrate the model’s utility in research, policy, and practice, I apply this model to understand contextual influences on Latino im/migrant students’ college access.
Cognitive failure during pregnancy

Abstract Many women report an increased incidence of cognitive failure in pregnancy. Psychological literature on cognitive failure suggests that it occurs more frequently at times of stress, when task demands are high and when people undergo a disruption in routine, all of which could apply to pregnancy. This study investigates links between women's reported cognitive failure during pregnancy and psychological and social factors. Thirty-one pregnant women were interviewed and asked to complete the Cognitive Failure Questionnaire and Middlesex Hospital Questionnaire at 4-weekly intervals during their pregnancy. The results suggest that women's cognitive failure scores in pregnancy are not significantly higher than the general female population, though some of the women studied did report very frequent cognitive failures. Levels of reported cognitive failure were related to maternal occupation, psychological and physical health prior to pregnancy. Differences in reported cognitive failure during pregnancy w.
Perturbative Interpretation of Adaptive Thouless-Anderson-Palmer Free Energy

In conventional well-known derivation methods for the adaptive Thouless-Anderson-Palmer (TAP) free energy, special assumptions that are difficult to mathematically justify except in some mean-field models, must be made. Here, we present a new adaptive TAP free energy derivation method. Using this derivation technique, without any special assumptions, the adaptive TAP free energy can be simply obtained as a high-temperature expansion of the Gibbs free energy.
Whose Text? Whose Context?

After a brief account of an old study on sociopolitical vs formalist styles of literary criticism and the lessons it taught about relating cultural objects to context, I turn to more recent work on talk-in-interaction and engage three themes: (1) That the events of conversation have a sense and import to participants which are at least partially displayed in each successive contribution, and which are thereby put to some degree under interactional control. Accordingly, academic accounts of the import of conversational `texts' can be endogenously grounded, and this is a worthy analytic aspiration; (2) The pursuit of this goal mandates relevant senses of context to be consulted for analysis, and these are senses and aspects of context which are demonstrably relevant to the participants in the event being examined, not necessarily ones relevant to the inquirer doing the analysis; and (3) Its technical grounds and mandate aside, this is a useful contraint on analysis in disciplining work to the indigenous preoccupations of the everyday world being grasped, and serving as a buffer against the potential for academic and theoretical imperialism which imposes intellectuals' preoccupations on a world without respect to their indigenous resonance.
Distributed coordination space: Toward a theory of distributed team process and performance

This paper discusses a theoretical framework designed to elucidate the many issues surrounding distributed team performance, emphasizing how work characteristics associated with such teams may alter both the processes and the products emerging from distributed interaction. It is suggested that distributed team performance can best be understood through conceptualization of a coordination space within which distributed interaction occurs over time and distance. The goal is to take a socio-technical approach to distributed team research so that one can explicate both the cognitive consequences of a lack of co-location as well as the social consequences affecting interaction and team development when work is technology-mediated. The overall objective is to present a framework of 'distributed coordination' such that the principles most appropriate for distributed team performance can be developed.
Male psychogenic sexual dysfunction: the role of masturbation

The role of masturbation in male psychogenic sexual dysfunction (MPSD) has been neglected by researchers and practitioners; this qualitative study explores that link through individual interviews with a clinic population by using grounded theory as a methodological approach and analytical style. Although a preference for functional sex with a partner was expressed by participants, our data suggest that masturbation dependence develops as a result of their sexual response having become conditional on a discrete set of behaviours, and is reinforced by cognitive components displaying different characteristics during masturbation and partner sex. The interrelation of both cognitive and behavioural components of sexual response is explored, and a theoretical model presented. Proposals for further study are suggested, and recommendations made for expansion of the formulation and treatment planning for MPSD.
Relationship between receptive and dendritic field size of amacrine cells in the rabbit retina.

1. Intracellular recordings were obtained from 40 amacrine cells in the isolated, superfused retina eyecup of the rabbit. Cells were subsequently labeled with horseradish peroxidase for morphological identification. Many of these cells displayed dendritic morphology consistent with that of amacrine cells described in prior anatomic studies, including starburst, A17, AII, and DAPI-3 cells. 2. The center receptive field of amacrine cells was measured with a 50- or 95-microns-wide, 6.0-mm-long rectangular slit of light that was displaced along its minor axis (parallel to the visual streak) in increments as small as 3 microns. The extent of the receptive field was calculated as the total distance over which the displaced slit could evoke a center response. Area summation of amacrine cells was measured with concentric spots of light with increasing diameters centered over the cell. 3. For a single amacrine cell, the receptive field size was comparable to the extent of its dendritic arbor. For the total population of amacrine cells, there was a strong, linear relationship between receptive field and dendritic field size. The receptive fields were, on average, 27% larger than the corresponding dendritic arbors, but this discrepancy can be accounted for entirely by tissue shrinkage associated with histological processing and a small imprecision of the light stimuli. Area summation measurements were consistent with those of receptive fields and were also related linearly to the dendritic field size of cells. 4. These findings indicate that even when the slit of light was placed at the distal edges of the dendritic arbor, synaptic inputs activated there were propagated effectively to the soma and recorded by microelectrodes placed there. In addition, amacrine cells were capable of summating synaptic inputs distributed throughout the entire arbor. 5. These results are inconsistent with the findings of prior computational modeling studies of passive, dendritic current flow in A17 and starburst amacrine cells that synaptic inputs on distal dendritic branches are isolated electrically from the soma and that these branches form autonomous, functional subunits. 6. The majority of amacrine cells encountered displayed light-evoked and/or spontaneous action potentials. These action potentials often took the form of high-amplitude somatic and low-amplitude dendritic spikes. On average, spiking amacrine cells showed considerably larger dendritic fields than nonspiking amacrine cells. In fact, all amacrine cells with arbors greater than 436 microns, which formed 45% of the total population, displayed spike activity. (ABSTRACT TRUNCATED AT 400 WORDS)
Instruction for Cytokine Expression in T Helper Lymphocytes in Relation to Proliferation and Cell Cycle Progression

T helper (Th) lymphocytes, when reactivated, recall expression of those cytokines they had been instructed to express in earlier activations, even in the absence of specific cytokine-inducing factors. In cells that memorize their expression, the cytokine genes are modified by chromatin rearrangement and demethylation, suggesting that they have been somatically imprinted. Here we show, by using inhibitors blocking the cell cycle in various stages, that for the instruction of a Th cell to express interleukin (IL)-4 or IL-10 upon restimulation, entry of the cell into the S phase of the first cell cycle after initial activation is required. Separation of the IL-4 receptor (IL-4R) and T cell antigen receptor (TCR) signals in time, demonstrates that this instruction is dependent on concomitant signaling from both receptors. In Th cells, inhibited to progress into the first S phase after activation, the IL-4R and TCR signals can be memorized for at least 1 d, priming the T cell to become instructed for expression of IL-4 upon restimulation, when entering the S phase after release of the cell cycle block. The requirement of the initial S phase of T cell activation, for instruction of Th cells to express IL-4 or IL-10 upon restimulation points to the decisive role of epigenetic modification of cytokine genes as a molecular correlate of the memory to express particular cytokines.