Miracle-dz/UniFAR-FTUs huggingface dataset:
Laparoscopic Excision Versus Open Excision for the Treatment of Choledochal Cysts: A Systematic Review and Meta-Analysis

In 1723, Vater first described choledochal cyst and in 1977, Todani et al classified this disease. For many years, open excision (OP) as the standard procedure made a great impact in the treatment of choledochal cyst. Since 1995, when Farello et al first reported laparoscopic choledochal cyst excision, laparoscopic excision (LA) has been used worldwide. However, its safety remains a major concern. The aim of this meta-analysis was to compare OP with LA in treating choledochal cyst and then to determine whether LA is safe and valid. The design of this study involved systematic review and meta-analysis. Data sources were Medline, Ovid, Elsevier, Google Scholar, Embase, and Cochrane library. The study selection entailed comparative cohort studies. For data extraction, 2 investigators independently assessed selected studies and extracted the following information: study characteristics, quality, outcomes data, etc. For the results, 7 comparative cohort studies about the effectiveness of LA compared with OP were performed meta-analysis. The results showed that although the LA group had a longer operative time (MD = 56.57; 95% CI = 32.20–80.93; P < 0.00001), LA had a shorter duration of hospital stay (MD = −1.93; 95% CI = −2.51 to −1.36; P < 0.00001), and recovery of bowel function (MD = −0.94; 95% CI = −1.33 to −0.55; P < 0.00001). Meta-analysis found no significant difference between most of the 2 groups: bile leak (RR = 0.60; 95% CI = 0.29–1.24; P = 0.17), abdominal bleeding (RR = 0.33; 95% CI = 0.01–8.98; P = 0.51), pancreatitis (RR = 0.26, 95% CI = 0.06–1.03; P = 0.06), total postoperative complications (RR = 1.04; 95% CI = 0.66–1.62; P = 0.88). The LA group had significant lower rates in intraoperative blood transfusion (RR = 0.20; 95% CI = 0.11–0.38; P < 0.00001), and adhesive intestinal obstruction (RR = 0.17, 95% CI = 0.04–0.77; P = 0.02). In conclusion, compared with open excision, laparoscopic excision is a safe, valid, and feasible alternative to open excision.
New solutions for improving reliability and reducing uncertainty in micro-milling

To advance micro milling technology it is necessary to study systematically the factors affecting process reliability, and develop new solutions for reducing uncertainty when machining components incorporating micro features. This paper reviews the main findings of the MEC’s research in this field. In particular, the factors affecting the dynamic stability of the micro milling process and the quality and surface finish of machined micro components are examined, and solutions are proposed to broaden its application. These include: new machining strategies that overcome some of the problems associated with the use of conventional ones for micro milling, such as the unpredictable life of micro cutters and their premature failure; new methods for tool failure detection; the use of metallurgical and mechanically modified materials for improving the process accuracy and resulting surface integrity; new methods for setting up machine working coordinate systems.
XFVHDL: a tool for the synthesis of fuzzy logic controllers

A tool for the synthesis of fuzzy controllers is presented in this paper. This tool takes as input the behavioral specification of a controller and generates its VHDL description according to a target architecture. The VHDL code can be synthesized by means of two implementation methodologies, ASIC and FPGA. The main advantages of using this approach are rapid prototyping, and the use of well-known commercial design environments like Synopsys, Mentor Graphics, or Cadence.
Deep Learning with Cellular Automaton-Based Reservoir Computing

Recurrent neural networks (RNNs) have been a prominent concept within artificial intelligence. They are inspired by biological neural networks (BNNs) and provide an intuitive and abstract representation of how BNNs work. Derived from the more generic artificial neural networks (ANNs), the recurrent ones are meant to be used for temporal tasks, such as speech recognition, because they are capable of memorizing historic input. However, such networks are very time consuming to train as a result of their inherent nature. Recently, echo state networks and liquid state machines have been proposed as possible RNN alternatives, under the name of reservoir computing (RC). Reservoir computers are far easier to train. In this paper, cellular automata (CAs) are used as a reservoir and are tested on the five-bit memory task (a well-known benchmark within the RC community). The work herein provides a method of mapping binary inputs from the task onto the automata and a recurrent architecture for handling the sequential aspects. Furthermore, a layered (deep) reservoir architecture is proposed. Performances are compared to earlier work, in addition to the single-layer version. Results show that the single cellular automaton (CA) reservoir system yields similar results to state-of-the-art work. The system comprised of two layered reservoirs does show a noticeable improvement compared to a single CA reservoir. This work lays the foundation for implementations of deep learning with CA-based reservoir systems.
Estimating live forest carbon dynamics with a Landsat-based curve-fitting approach

Direct estimation of aboveground biomass with spectral reflectance data has proven challenging for high biomass forests of the Pacific Northwestern United States. We present an alternative modeling strategy which uses Landsat's spatial, spectral and temporal characteristics to predict live forest carbon through integration of stand age and site index maps and locally calibrated Chapman-Richards curves. Predictions from the curve-fit model were evaluated at the local and landscape scales using two periods of field inventory data. At the pixel-level, the curve-fit model had large positive bias statistics and at the landscape scale over-predicted study area carbon for both inventory periods. Despite the over-estimation, the change in forest carbon estimated by the curve-fit model was well within the standard error of the inventory estimates. In addition to validating the curve-fit models carbon predictions we used Landsat data to evaluate the degree to which the field inventory plots captured the forest conditions of the study area. Landsat-based frequency histograms revealed the systematic sample of inventory plots effectively captured the broad range of forest conditions found inthe study area, whereas stand age trajectories revealed a temporally punctuated shift in landuse which was not spectrally detected by the inventory sample.
Association between workplace psychosocial factors and mental health in Black, Hispanic, and White women: Cross-sectional findings from the National Health Interview Survey

ABSTRACT Research evaluating the relation of workplace psychosocial factors to mental health among U.S. women of different racial/ethnic backgrounds is limited. This study investigated the relationship between work-related psychosocial factors and mental health among non-Hispanic Black, Hispanic, and non-Hispanic White women using data from the 2010 National Health Interview Survey. Independent variables of interest included job insecurity, workplace harassment, and work-family conflict (WFC). Multiple Poisson regression models were used to examine the associations between the outcome and independent variables. The prevalence of unfavorable mental health was highest among non-Hispanic Black women (36%) compared to Hispanic (34%) and non-Hispanic White (30%) women. A higher proportion of non-Hispanic Black women reported WFC compared to Hispanics and non-Hispanic Whites (χ2 = 15.50, p < .01), while more Hispanics reported job insecurity (χ2 = 116.81, p < .01). Prevalence of workplace harassment did not differ significantly by race/ethnicity. Odds of unfavorable mental health were significantly higher for women reporting psychosocial work factors. Unexpectedly, a greater association between psychosocial work factors and unfavorable mental health was observed among non-Hispanic White women compared to non-White women; however, caution should be taken in interpreting these cross-sectional results. Future studies should investigate temporal associations and additional psychosocial variables that were not available for use in the current study.
Transient Input Impedance Modeling of Rectifiers for RF Energy Harvesting Applications

This brief presents a model for the input impedance of the RF rectifiers during charging. It uses a power-based method and finds a closed form equation for the transient variation of the input impedance. To validate the model, a typical single stage rectifier is designed using Schottky diodes and simulated at 900 MHz using ADS. The simulation results show a good agreement with the proposed model. Moreover the rectifier is realized on PCB. The measurements agree well with the values calculated using the model which further confirms the proposed model.
An exploratory genome-wide analysis of genetic risk for alcoholic hepatitis

Abstract Objectives: To elucidate the genetic variability between heavy drinkers with and without alcoholic hepatitis (AH). Materials and methods: An exploratory genome-wide association study (GWAS; NCT02172898) was conducted comparing 90 AH cases with 93 heavy drinking matched controls without liver disease in order to identify variants or genes associated with risk for AH. Individuals were genotyped using the multi-ethnic genotyping array, after which the data underwent conventional quality control. Using bioinformatics tools, pathways associated with AH were explored on the basis of individual variants, and based on genes with a higher ’burden’ of functional variation. Results: Although no single variant reached genome-wide significance, an association signal was observed for PNPLA3 rs738409 (p = .01, OR 1.9, 95% CI 1.1–3.1), a common single nucleotide polymorphism that has been associated with a variety of liver-related pathologies including alcoholic cirrhosis. Using the improved gene set enrichment analysis for GWAS tool, it was shown that, based on the single variants’ trait-association p-values, multiple pathways were associated with risk for AH with high confidence (false discovery rate [FDR] < 0.05), including several pathways involved in lymphocyte activation and chemokine signaling, which coincides with findings from other research groups. Several Tox Functions and Canonical Pathways were highlighted using Ingenuity Pathway Analysis, with an especially conspicuous role for pathways related to ethanol degradation, which is not surprising considering the phenotype of the genotyped individuals. Conclusion: This preliminary analysis suggests a role for PNPLA3 variation and several gene sets/pathways that may influence risk for AH among heavy drinkers.
New Insights into Different Reproductive Effort and Sexual Recruitment Contribution between Two Geographic Zostera marina L. Populations in Temperate China

Seagrasses are important components of global coastal ecosystems, and the eelgrass Zostera marina L. is widely distributed along the Atlantic and Pacific coasts in the temperate northern hemisphere, but limited datum related to the contribution of sexual reproduction to population recruitment have been reported. This study aimed to understand eelgrass sexual reproduction and population recruitment in Swan Lake (SLL), and Huiquan Bay (HQB) was included for comparison. Random sampling, permanent quadrats or cores and laboratory seed germination-based experimental methods were employed. The flowering, seed production, seed banks, seed germination, seedling survival, and seedling growth of eelgrass were investigated from July 2014 to December 2015 to evaluate the contribution of sexual reproduction to population recruitment. Results indicated a dominant role of asexual reproduction in HQB, while sexual reproduction played a relatively important role in SLL. The highest flowering shoot density in SLL was 517.27 ± 504.29 shoots m−2 (June) and represented 53.34% of the total shoots at the center site. The potential seed output per reproductive shoot and per unit area in SLL were 103.67 ± 37.95 seeds shoot−1 and 53,623.66 ± 19,628.11 seeds m−2, respectively. The maximum seed bank density in SLL was 552.21 ± 204.94 seeds m−2 (October). Seed germination mainly occurred from the middle of March to the end of May, and the highest seedling density was 296.88 ± 274.27 seedlings m−2 in April. The recruitment from seedlings accounted for 41.36% of the Z. marina population recruitment at the center site, while the sexual recruitment contribution at the patch site (50.52%) was greater than that at the center site. Seeds in SLL were acclimated to spring germination, while in HQB, they were acclimated to autumn germination (early October–late November). Seed bank density in HQB was very low, with a value of 254.35 ± 613.34 seeds m−2 (early October). However, seeds in HQB were significantly larger and heavier than those in SLL (size: P = 0.004; weight: P < 0.001). The recruitment from seedlings accounted for as low as 2.53% of the Z. marina population recruitment in HQB. Our laboratory seed germination experiment, which was conducted in autumn, showed that the seed germination percent in HQB was significantly greater than in SLL at optimal germination temperatures (10 and 15°C; P < 0.001). A laboratory seed germination test at suitable temperature may be a potential novel approach to identify the ecological differences among different geographic populations. It is suggested that the Z. marina population recruitment may have different strategies and adapt to specific local conditions, such as in SLL and HQB, and the temperature regime may control morphological and phonological variations.
Descriptor : MicroRNA screening identi fi es miR-134 as a regulator of poliovirus and enterovirus 71 infection

MicroRNAs (miRNAs) regulate virus replication through multiple mechanisms. Poliovirus causes a highly debilitating disease and though global efforts to eradicate polio have sharply decreased polio incidence, unfortunately three countries (Afghanistan, Nigeria and Pakistan) remain polio-endemic. We hypothesize that understanding the host factors involved in polio replication will identify novel prophylactic and therapeutic targets against polio and related viruses. In this data set, employing genome wide screens of miRNA mimics and inhibitors, we identified miRNAs which significantly suppressed polio replication. Specifically, miR-134 regulates poliovirus replication via modulation of ras-related nuclear protein (RAN), an important component of the nuclear transport system. MiR-134 also inhibited other Picornaviridae viruses including EV71, a growing concern and a high priority for vaccination in Asian countries like China. These findings demonstrate a novel mechanism for miRNA regulation of poliovirus and other Picornaviridae viruses in host cells, and thereby may provide a novel approach in combating infection and a potential approach for the development of anti-Picornaviridae strategies.
Towards the identification of a gene for prostrate tillers in barley (Hordeum vulgare L.)

Tiller angle, an important agronomic trait, contributes to crop production and plays a vital role in breeding for plant architecture. A barley line V-V-HD, which has prostrate tillers during vegetative growth and erect tillers after booting, is considered the ideal type for repressing weed growth and increasing leaf area during early growth. Genetic analysis identified that the prostrate trait in V-V-HD is controlled by a single gene. A double haploid population with 208 lines from V-V-HD × Buloke was used to map the prostrate growth gene. Ninety-six SNP markers were used for primary mapping, and subsequently, SSR and InDel markers were used for fine mapping. The gene was fine-mapped to a 3.53 Mb region on chromosome 3HL between the markers InDelz3028 and InDelz3032 with 52 candidate genes located in this region. Gene annotation analysis of the 52 genes within the target region indicated that a gene involved in zinc-ion binding (gene ID HORVU3Hr1G090910) is likely to be the candidate gene for prostrate growth in V-V-HD, and is linked to the denso/sdw gene. Association analysis showed that prostrate plants were shorter, flowered later.
Whole-Body Nonlinear Model Predictive Control Through Contacts for Quadrupeds

In this letter, we present a whole-body nonlinear model predictive control approach for rigid body systems subject to contacts. We use a full-dynamic system model which also includes explicit contact dynamics. Therefore, contact locations, sequences, and timings are not prespecified but optimized by the solver. Yet, using numerical and software engineering allows for running the nonlinear Optimal Control solver at rates up to 190 Hz on a quadruped for a time horizon of half a second. This outperforms the state-of-the-art by at least one order of magnitude. Hardware experiments in the form of periodic and nonperiodic tasks are applied to two quadrupeds with different actuation systems. The obtained results underline the performance, transferability, and robustness of the approach.
Panoramic and skull imaging may aid in the identification of multiple myeloma lesions

Background The purpose of this study was to investigate the presence of punched-out lesions in craniofacial bones using three different radiographic protocols in a large cohort of patients. Material and Methods One hundred fifty-five MM patients were evaluated using panoramic and skull (frontal and lateral) radiographs, which were performed in all patients at the time of MM diagnosis. The diagnostic potential for detecting punched-out lesions was compared among the radiographic techniques. Results MM punched-out lesions were identified in 135 (87%) panoramic radiographs, 141 (91%) frontal and 144 (93%) lateral skull radiographs. Punched out-lesions were synchronously present in skull and jawbones in 129 (83.23 %) cases. The lesions were detected exclusively in skull in 18 (11.61%) cases and exclusively in jawbones in 6 (3.87%) cases. Punched out-lesion mainly affected the skull and the jawbones in a synchronous way (p<0.001) rather than separately. Conclusions All investigated radiographic techniques (panoramic, frontal and lateral skull approaches) demonstrated high detection rates for MM punched-out lesions in craniofacial bones. Panoramic radiography may aid to the radiographic protocols to identify multiple myeloma bone lesions. Key words:Multiple myeloma, osteolytic lesions, panoramic radiography.
ASC Methylation and Interleukin-1&bgr; Are Associated with Aerobic Capacity in Heart Failure

Background Aerobic capacity, as measured by peak oxygen uptake (V˙O2), is one of the most powerful predictors of prognosis in heart failure (HF). Inflammation is a key factor contributing to alterations in aerobic capacity, and interleukin (IL)-1 cytokines are implicated in this process. The adaptor protein ASC is necessary for inflammasome activation of IL-1&bgr; and IL-18. ASC expression is controlled through epigenetic modification; lower ASC methylation is associated with worse outcomes in HF. The purpose of this study is to examine the relationships between ASC methylation, IL-1&bgr;, and IL-18 with V˙O2peak in persons with HF. Methods This study examined the relationship between ASC methylation, IL-1&bgr;, and IL-18 with V˙O2peak in 54 stable outpatients with HF. All participants were NYHA class II or III, not engaged in an exercise program, and physically able to complete an exercise treadmill test. Results Mean V˙O2peak was 16.68 ± 4.7 mL·kg−1·min−1. V˙O2peak was positively associated with mean percent ASC methylation (r = 0.47, P = 0.001) and negatively associated with IL-1&bgr; (r = −0.38, P = 0.007). Multiple linear regression models demonstrated that V˙O2peak increased by 2.30 mL·kg−1·min−1 for every 1% increase in ASC methylation and decreased by 1.91 mL·kg−1·min−1 for every 1 pg·mL−1 increase in plasma IL-1&bgr;. Conclusions Mean percent ASC methylation and plasma IL-1&bgr; levels are associated with clinically meaningful differences in V˙O2peak in persons with HF. Inflammasome activation may play a mechanistic role in determining aerobic capacity. ASC methylation is a potentially modifiable mechanism for reducing the inflammatory response, thereby improving aerobic capacity in HF.
Prey reduce risk-taking and abundance in the proximity of predators

Abstract Prey have evolved anti-predator defences that reduce or eliminate the risk of predation. Predators often reproduce at specific sites over many years causing permanent threats to local prey species. Such prey may respond by moving elsewhere thereby reducing local population abundance, or they may stay put and adjust their behavior to the presence of predators. We tested these predictions by analyzing population abundance and anti-predator behavior within 100 m of and 500 m away from nests of sparrowhawks Accipiter nisus and goshawks A. gentilis for 80 species of birds. Population abundance of prey was reduced by 11% near goshawk nests and by 15% near sparrowhawk nests when compared with nearby control sites in similar habitats. Flight initiation distance (FID) of prey, estimated as the distance at which birds took flight when approached by a human, increased by 50% in the presence of hawk nests, providing evidence of adjustment of anti-predator behavior to prevailing risks of predation. Susceptibility to predation was estimated as log transformed abundance of the observed number of prey items obtained from prey remains collected around nests minus log transformed expected number of prey according to point counts of breeding birds. FID increased from 10 to 46 m with increasing susceptibility of prey species to predation by the goshawk and from 12 to 15 m with increasing susceptibility of prey species to predation by the sparrowhawk. These findings suggest that prey adjust their distribution and anti-predator behavior to the risk of predation.
Shifts in Plant Community Assembly Processes across Growth Forms along a Habitat Severity Gradient: A Test of the Plant Functional Trait Approach

Species respond to changes in their environments. A core goal in ecology is to understand the process of plant community assembly in response to a changing climate. Examining the performance of functional traits and trait-based assembly patterns across species among different growth forms is a useful way to explore the assembly process. In this study, we constructed a habitat severity gradient including several environment factors along a 2300 m wide elevational range at Taibai Mountain, central China. Then we assessed the shift on functional trait values and community assembly patterns along this gradient across species among different growth forms. We found that (1) although habitat-severity values closely covaried with elevation in this study, an examined communities along a habitat severity gradient might reveal community dynamics and species responses under future climate change. (2) the occurrence of trait values along the habitat severity gradient across different growth forms were similar, whereas the assembly pattern of herbaceous species was inconsistent with the community and woody species. (3) the trait-trait relationships of herbaceous species were dissimilar to those of the community and woody species. These results suggest that (1) community would re-assemble along habitat severity gradient through environmental filtering, regardless of any growth forms and that (2) different growth forms' species exhibiting similar trait values' shift but different trait-trait relationship by different trait combinations.