Miracle-dz/UniFAR-FTUs huggingface dataset:
Are group size and composition associated with treatment outcomes in group cognitive behavioural therapy for chronic pain?

Abstract This study explored whether group size and group member characteristics (age, sex, and compensation status) were associated with patient outcomes (changes in pain and disability). Retrospective analyses of outcome data obtained from 2 independently run group cognitive behavioural therapy (CBT) programs for chronic pain (Program A: N = 317 and Program B: N = 693) were conducted. Intracluster correlations were significant in both studies, indicating group-level effects on patient outcomes in both group CBT programs for chronic pain. Mixed modelling revealed that group size and group member characteristics (age, sex, and compensation status) were related to patient outcomes, but not consistently across programs. The results of our analyses confirm the contribution of group composition to individual treatment outcomes in group CBT for chronic pain, and highlight factors that have the potential to contribute to group-level variability in patient outcomes. Further research is needed to identify the mechanisms that account for the impact of group characteristics on the efficacy of CBT for chronic pain.
Systematic identification of functionally relevant risk alleles to stratify aggressive versus indolent prostate cancer

Novel approaches for classification, including molecular features, are needed to direct therapy for men with low-grade prostate cancer (PCa), especially men on active surveillance. Risk alleles identified from genome-wide association studies (GWAS) could improve prognostication. Those risk alleles that coincided with genes and somatic copy number aberrations associated with progression of PCa were selected as the most relevant for prognostication. In a systematic literature review, a total of 698 studies were collated. Fifty-three unique SNPs residing in 29 genomic regions, including 8q24, 10q11 and 19q13, were associated with PCa progression. Functional studies implicated 21 of these single nucleotide polymorphisms (SNPs) as modulating the expression of genes in the androgen receptor pathway and several other oncogenes. In particular, 8q24, encompassing MYC, harbours a high density of SNPs conferring unfavourable pathological characteristics in low-grade PCa, while a copy number gain of MYC in low-grade PCa was associated with prostate-specific antigen recurrence after radical prostatectomy. By combining GWAS data with gene expression and structural rearrangements, risk alleles were identified that could provide a new basis for developing a prognostication tool to guide therapy for men with early prostate cancer.
A low cost fleet management system with real time video surveillance using peer-to-peer connection

In most existing video surveillance architectures for fleet management, a vehicle sends entire video stream back to the central server. This wastes bandwidth and cost. In this paper, we present a fleet management system that provides real time video surveillance function. Only when a surveillance service is initiated, an immediate peer-to-peer connection is built through the interactive connectivity establishment to traverse network address translation. The proposed system is a web-based design which can be easily developed and allow an operator to efficiently manage the fleet via a browser from anywhere.
Dietary habits, poverty, and chronic kidney disease in an urban population.

BACKGROUND Poverty is associated with chronic kidney disease (CKD) in the United States and worldwide. Poor dietary habits may contribute to this disparity. STUDY DESIGN Cross-sectional study. SETTING AND PARTICIPANTS A total of 2,058 community-dwelling adults aged 30 to 64 years residing in Baltimore City, Maryland. PREDICTORS Adherence to the Dietary Approaches to Stop Hypertension (DASH) diet. DASH scoring based on 9 target nutrients (total fat, saturated fat, protein, fiber, cholesterol, calcium, magnesium, sodium, and potassium); adherence defined as score ≥4.5 of maximum possible score of 9. Poverty (self-reported household income <125% of 2004 Department of Health and Human Services guideline) and nonpoverty (≥125% of guideline). OUTCOMES AND MEASUREMENTS CKD defined as estimated glomerular filtration rate <60 mL/minute/1.73 m(2) (CKD epidemiology collaboration equation). Multivariable logistic regression was used to calculate adjusted odds ratios (AORs) for relation of DASH score tertile and CKD, stratified by poverty status. RESULTS Among 2,058 participants (mean age 48 years; 57% black; 44% male; 42% with poverty), median DASH score was low, 1.5 (interquartile range, 1-2.5). Only 5.4% were adherent. Poverty, male sex, black race, and smoking were more prevalent among the lower DASH score tertiles, whereas higher education and regular health care were more prevalent among the highest DASH score tertile (P < .05 for all). Fiber, calcium, magnesium, and potassium intake were lower, and cholesterol higher, among the poverty compared with nonpoverty group (P < .05 for all), with no difference in sodium intake. A total of 5.6% of the poverty and 3.8% of the nonpoverty group had CKD (P = .05). The lowest DASH tertile (compared with the highest) was associated with more CKD among the poverty (AOR 3.15, 95% confidence interval 1.51-6.56), but not among the nonpoverty group (AOR 0.73, 95% confidence interval 0.37-1.43; P interaction = .001). CONCLUSIONS Poor dietary habits are strongly associated with CKD among the urban poor and may represent a target for interventions aimed at reducing disparities in CKD.
A robust current control based on proportional-integral observers for permanent magnet synchronous machines

This paper deals with a novel robust current control scheme for Permanent Magnet Synchronous Machine based on the conventional cascade structure. The main idea is to substitute the commonly used decoupling network, which requires the precise knowledge of the system parameters in any working condition, with a more flexible and robust scheme. In particular, the traditional configuration is improved by mean of two proportional-integral observers which allow the preservation of the drive performances under the effects of disturbance. The improved robustness is achieved maintaining the reliable basic scheme with a pure proportional controller in the forward path with advantages in terms of design and tuning. A genetic algorithm is used to optimize the controller and the observer parameters. This multi-objective optimization leads to a good stability and an overall improved performance of the drive above all the operative range. The choice of the optimal solution is based on a novel fitness function which takes into account both dynamical features and disturbance rejection capabilities of the system. The effectiveness of the proposed control scheme is verified by mean of numerical simulations and experiments as well.
The Impact of Interaction Networks on Lurkers' Behavior in Online Community

Online product-review communities provide a wealth of information generated by users about various products. Community members interact with one another through replies to reviews and through "likes" to show their interest in product reviews. Individuals who do not interact or participate in product-review discussions are known as "lurkers. " Lurkers are potential consumers of products under consideration and are influenced by product reviews. Collective action theory indicates that generating public goods may trigger the generation of more public goods or lead to collective action. We extend research on the interactive features of product-review networks by considering the out degree centralization, density, and microstructure of product-review networks. Our results offer insights into the application of collective action in an online community and may aid operators of online community platforms in designing mechanisms that encourage user interaction and increase lurkers' interest.
Long‐term right ventricular changes in mustard‐exposed patients: A historical cohort

Mustard gas (MG) is a chemical warfare agent widely used in the Iran‐Iraq War. Its catastrophic effects on the lungs, eyes, and skin have been well studied. However, it also affects the cardiovascular system. We aimed to evaluate the long‐term effect of MG on right ventricular (RV) function.
Ecological Interactions in Dinosaur Communities: Influences of Small Offspring and Complex Ontogenetic Life Histories

Because egg-laying meant that even the largest dinosaurs gave birth to very small offspring, they had to pass through multiple ontogenetic life stages to adulthood. Dinosaurs’ successors as the dominant terrestrial vertebrate life form, the mammals, give birth to live young, and have much larger offspring and less complex ontogenetic histories. The larger number of juveniles in dinosaur as compared to mammal ecosystems represents both a greater diversity of food available to predators, and competitors for similar-sized individuals of sympatric species. Models of population abundances across different-sized species of dinosaurs and mammals, based on simulated ecological life tables, are employed to investigate how differences in predation and competition pressure influenced dinosaur communities. Higher small- to medium-sized prey availability leads to a normal body mass-species richness (M-S) distribution of carnivorous dinosaurs (as found in the theropod fossil record), in contrast to the right-skewed M-S distribution of carnivorous mammals (as found living members of the order Carnivora). Higher levels of interspecific competition leads to a left-skewed M-S distribution in herbivorous dinosaurs (as found in sauropods and ornithopods), in contrast to the normal M-S distribution of large herbivorous mammals. Thus, our models suggest that differences in reproductive strategy, and consequently ontogeny, explain observed differences in community structure between dinosaur and mammal faunas. Models also show that the largest dinosaurian predators could have subsisted on similar-sized prey by including younger life stages of the largest herbivore species, but that large predators likely avoided prey much smaller than themselves because, despite predicted higher abundances of smaller than larger-bodied prey, contributions of small prey to biomass intake would be insufficient to satisfy meat requirements. A lack of large carnivores feeding on small prey exists in mammals larger than 21.5 kg, and it seems a similar minimum prey-size threshold could have affected dinosaurs as well.
The AMP-Activated Protein Kinase Homolog Snf1 Concerts Carbon Utilization, Conidia Production and the Biosynthesis of Secondary Metabolites in the Taxol-Producer Pestalotiopsis microspora

Highly conserved, the Snf1/AMPK is a central regulator of carbon metabolism and energy production in the eukaryotes. However, its function in filamentous fungi has not been well established. In this study, we reported functional characterization of Snf1/AMPK in the growth, development and secondary metabolism in the filamentous fungus Pestalotiopsis microspora. By deletion of the yeast SNF1 homolog, we found that it regulated the utilization of carbon sources, e.g., sucrose, demonstrating a conserved function of this kinase in filamentous fungus. Importantly, several novel functions of SNF1 were unraveled. For instance, the deletion strain displayed remarkable retardation in vegetative growth and pigmentation and produced a diminished number of conidia, even in the presence of the primary carbon source glucose. Deletion of the gene caused damages in the cell wall as shown by its hypersensitivities to Calcofluor white and Congo red, suggesting a critical role of Snf1 in maintaining cell wall integrity. Furthermore, the mutant strain Δsnf1 was hypersensitive to stress, e.g., osmotic pressure (1 M sorbitol), drug G418 and heat shock, though the mechanism remains to be illustrated. Significantly, disruption of the gene altered the production of secondary metabolites. By high-performance liquid chromatography (HPLC) profiling, we found that Δsnf1 barely produced secondary metabolites, e.g., the known product pestalotiollide B. This study suggests that Snf1 is a key regulator in filamentous fungus Pestalotiopsis microspora concerting carbon metabolism and the filamentous growth, conidiation, cell wall integrity, stress tolerance and the biosynthesis of secondary metabolites.
Colorectal carcinomas with CpG island methylator phenotype 1 frequently contain mutations in chromatin regulators.

BACKGROUND & AIMS Subgroups of colorectal carcinomas (CRCs) characterized by DNA methylation anomalies are termed CpG island methylator phenotype (CIMP)1, CIMP2, or CIMP-negative. The pathogenesis of CIMP1 colorectal carcinomas, and their effects on patients' prognoses and responses to treatment, differ from those of other CRCs. We sought to identify genetic somatic alterations associated with CIMP1 CRCs. METHODS We examined genomic DNA samples from 100 primary CRCs, 10 adenomas, and adjacent normal-appearing mucosae from patients undergoing surgery or colonoscopy at 3 tertiary medical centers. We performed exome sequencing of 16 colorectal tumors and their adjacent normal tissues. Extensive comparison with known somatic alterations in CRCs allowed segregation of CIMP1-exclusive alterations. The prevalence of mutations in selected genes was determined from an independent cohort. RESULTS We found that genes that regulate chromatin were mutated in CIMP1 CRCs; the highest rates of mutation were observed in CHD7 and CHD8, which encode members of the chromodomain helicase/adenosine triphosphate-dependent chromatin remodeling family. Somatic mutations in these 2 genes were detected in 5 of 9 CIMP1 CRCs. A prevalence screen showed that nonsilencing mutations in CHD7 and CHD8 occurred significantly more frequently in CIMP1 tumors (18 of 42 [43%]) than in CIMP2 (3 of 34 [9%]; P < .01) or CIMP-negative tumors (2 of 34 [6%]; P < .001). CIMP1 markers had increased binding by CHD7, compared with all genes. Genes altered in patients with CHARGE syndrome (congenital malformations involving the central nervous system, eye, ear, nose, and mediastinal organs) who had CHD7 mutations were also altered in CRCs with mutations in CHD7. CONCLUSIONS Aberrations in chromatin remodeling could contribute to the development of CIMP1 CRCs. A better understanding of the biological determinants of CRCs can be achieved when these tumors are categorized according to their epigenetic status.
Increased plasma olfactomedin 2 after interventional therapy is a predictor for restenosis in lower extremity arteriosclerosis obliterans patients

Abstract Animal studies have indicated that olfactomedin 2 (OLFM2) is involved in the process of vascular remolding. The aim of the present study was to investigate circulating OLFM2 levels in lower extremity arteriosclerosis obliterans (LEASO) patients and the association of OLFM2 with postoperative restenosis in patients. A total of 203 LEASO patients were enrolled in the present study. Plasma OLFM2 was measured before and 6 h after interventional therapy. After 6 months, patients were divided into a restenosis group and a non-restenosis group. Inter-group and intra-group differences in plasma OLFM2 were compared. The correlation between plasma OLFM2 and the severity of restenosis was analyzed by Spearman’s correlation analysis. An receiver operating characteristic (ROC) curve was used to evaluate the predictive efficacy of plasma OLFM2 on restenosis. Logistic regression was used to determine the risk factors for restenosis. Postoperative OLFM2 in the restenosis group was significantly higher compared with the non-restenosis group (34.07 ± 5.76 ng/mL vs. 19.53 ± 2.99 ng/mL). No significant difference in preoperative plasma OLFM2 levels was identified between the two groups (10.92 ± 2.49 ng/mL vs. 11.54 ± 3.18 ng/mL). Postoperative OLFM2 levels were positively correlated with the severity of restenosis (r = 0.728, p < .001). The area under the ROC curve was 0.902 (95% confidence interval (CI): 0.874–0.965), with a cutoff value of 26.91 ng/mL (95% CI: 26.16–28.32). Plasma OLFM2 was an independent risk factor for restenosis. Our results suggest that plasma OLFM2 is a potential biomarker for restenosis and may be a novel target for the treatment of restenosis.
SeqFace: Make full use of sequence information for face recognition

Deep convolutional neural networks (CNNs) have greatly improved the Face Recognition (FR) performance in recent years. Almost all CNNs in FR are trained on the carefully labeled datasets containing plenty of identities. However, such high-quality datasets are very expensive to collect, which restricts many researchers to achieve state-of-the-art performance. In this paper, we propose a framework, called SeqFace, for learning discriminative face features. Besides a traditional identity training dataset, the designed SeqFace can train CNNs by using an additional dataset which includes a large number of face sequences collected from videos. Moreover, the label smoothing regularization (LSR) and a new proposed discriminative sequence agent (DSA) loss are employed to enhance discrimination power of deep face features via making full use of the sequence data. Our method achieves excellent performance on Labeled Faces in the Wild (LFW), YouTube Faces (YTF), only with a single ResNet. The code and models are publicly available on-line (this https URL).
Peak-to-Average Power Ratio of Multicarrier Faster-Than-Nyquist Signals: Distribution, Optimization and Reduction

Multicarrier faster-than-Nyquist (MFTN) is a spectral efficient transmission scheme for future communication systems. However, as one of the most important drawbacks of multicarrier transmission systems, the peak-to-average power ratio (PAPR) of MFTN signals is still not clear yet. In this paper, we investigate the PAPR of MFTN signals for nonlinear satellite communication systems. First of all, the PAPR distribution of MFTN signals under various practical situations is evaluated, and we show that the PAPR of MFTN signals is closely related to the number of subcarriers, the shaping pulse, and the time–frequency packing factors. Moreover, different from conventional Nyquist multicarrier signals, certain time–frequency packing in MFTN will however, improve the PAPR performance. Then, the PAPR of MFTN signals under the given spectral efficiency is considered. By jointly optimizing the time–frequency spacing to minimize the PAPR, we show that the MFTN combined with low-order modulation could be more energy efficient than the corresponding Nyquist high-order modulation signals. Finally, we investigate the PAPR reduction for MFTN signals. Specifically, a selective mapping-based alternative-signal scheme, which mainly intended for the conventional Nyquist multicarrier signals, is extended to the MFTN signaling system. It is shown that the PAPR reduction performance of the considered scheme is robust to the time–frequency packing, and even approaches the conventional orthogonal frequency-division multiplexing system. Our numerical results validate that besides the high spectral efficiency, the MFTN may be also an energy efficient transmission scheme for next-generation satellite communication systems.
Pattern-Based NN Control of a Class of Uncertain Nonlinear Systems

This paper presents a pattern-based neural network (NN) control approach for a class of uncertain nonlinear systems. The approach consists of two phases of identification and another two phases of recognition and control. First, in the phase (i) of identification, adaptive NN controllers are designed to achieve closed-loop stability and tracking performance of nonlinear systems for different control situations, and the corresponding closed-loop control system dynamics are identified via deterministic learning. The identified control system dynamics are stored in constant radial basis function (RBF) NNs, and a set of constant NN controllers are constructed by using the obtained constant RBF networks. Second, in the phase (ii) of identification, when the plant is operated under different or abnormal conditions, the system dynamics under normal control are identified via deterministic learning. A bank of dynamical estimators is constructed for all the abnormal conditions and the learned knowledge is embedded in the estimators. Third, in the phase of recognition, when one identified control situation recurs, by using the constructed estimators, the recurred control situation will be rapidly recognized. Finally, in the phase of pattern-based control, based on the rapid recognition, the constant NN controller corresponding to the current control situation is selected, and both closed-loop stability and improved control performance can be achieved. The results presented show that the pattern-based control realizes a humanlike control process, and will provide a new framework for fast decision and control in dynamic environments. A simulation example is included to demonstrate the effectiveness of the approach.
SPR-based PCF D-type sensor based on a metamaterial composed of planar metals for refractive index sensing

This paper presents a numerically investigation of the performance analysis of a conventional photonic crystal fiber (PCF) with a planar metamaterials structure for refractive index sensing, based on surface plasmon resonance (SPR), using the finite element method (FEM). We study the concentration metamaterials conformed by the aluminium oxide (Al2O3) and silver (Ag) and compared its performance with a single metal (Ag), assessing their impacts in the effective refractive index. Furthermore, we also use different types of mechanics to describe the effects of varying the structural parameters sensor on the evanescent field and the sensor performance.
Appraisal of Space Words and Allocation of Emotion Words in Bodily Space

The body-specificity hypothesis (BSH) predicts that right-handers and left-handers allocate positive and negative concepts differently on the horizontal plane, i.e., while left-handers allocate negative concepts on the right-hand side of their bodily space, right-handers allocate such concepts to the left-hand side. Similar research shows that people, in general, tend to allocate positive and negative concepts in upper and lower areas, respectively, in relation to the vertical plane. Further research shows a higher salience of the vertical plane over the horizontal plane in the performance of sensorimotor tasks. The aim of the paper is to examine whether there should be a dominance of the vertical plane over the horizontal plane, not only at a sensorimotor level but also at a conceptual level. In Experiment 1, various participants from diverse linguistic backgrounds were asked to rate the words “up”, “down”, “left”, and “right”. In Experiment 2, right-handed participants from two linguistic backgrounds were asked to allocate emotion words into a square grid divided into four boxes of equal areas. Results suggest that the vertical plane is more salient than the horizontal plane regarding the allocation of emotion words and positively-valenced words were placed in upper locations whereas negatively-valenced words were placed in lower locations. Together, the results lend support to the BSH while also suggesting a higher saliency of the vertical plane over the horizontal plane in the allocation of valenced words.