Miracle-dz/UniFAR-FTUs huggingface dataset:
Classification of sentiments in short-text: an approach using mSMTP measure

Sentiment analysis or opinion mining is an automated process to recognize opinion, moods, emotions, attitude of individuals or communities through natural language processing, text analysis, and computational linguistics. In recent years, many studies concentrated on numerous blogs, tweets, forums and consumer review websites to identify sentiment of the communities. The information retrieved from social networking site will be in short informal text because of limited characters in blogging site or consumer review websites. Sentiment analysis in short-text is a challenging task, due to limitation of characters, user tends to shorten his/her conversation, which leads to misspellings, slang terms and shortened forms of words. Moreover, short-texts consists of more number of presence and absence of term/feature compared to regular text. In this work, our major goal is to classify sentiments into positive, negative or neutral polarity using new similarity measure. The proposed method embeds modified Similarity Measure for Text Processing (mSMTP) with K-Nearest Neighbor (KNN) classifier. The effectiveness of the proposed method is evaluated by comparing with Euclidean Distance, Cosine Similarity, Jaccard Coefficient and Correlation Coefficient. The proposed method is also compared with other classifiers like Support Vector Machine and Random Forest using benchmark dataset. The classification results are evaluated based on Accuracy, Precision, Recall and F-measure.
PalmTouch: Using the Palm as an Additional Input Modality on Commodity Smartphones

Touchscreens are the most successful input method for smartphones. Despite their flexibility, touch input is limited to the location of taps and gestures. We present PalmTouch, an additional input modality that differentiates between touches of fingers and the palm. Touching the display with the palm can be a natural gesture since moving the thumb towards the device's top edge implicitly places the palm on the touchscreen. We present different use cases for PalmTouch, including the use as a shortcut and for improving reachability. To evaluate these use cases, we have developed a model that differentiates between finger and palm touch with an accuracy of 99.53% in realistic scenarios. Results of the evaluation show that participants perceive the input modality as intuitive and natural to perform. Moreover, they appreciate PalmTouch as an easy and fast solution to address the reachability issue during one-handed smartphone interaction compared to thumb stretching or grip changes.
Non-mammalian models in behavioral neuroscience: consequences for biological psychiatry

Current models in biological psychiatry focus on a handful of model species, and the majority of work relies on data generated in rodents. However, in the same sense that a comparative approach to neuroanatomy allows for the identification of patterns of brain organization, the inclusion of other species and an adoption of comparative viewpoints in behavioral neuroscience could also lead to increases in knowledge relevant to biological psychiatry. Specifically, this approach could help to identify conserved features of brain structure and behavior, as well as to understand how variation in gene expression or developmental trajectories relates to variation in brain and behavior pertinent to psychiatric disorders. To achieve this goal, the current focus on mammalian species must be expanded to include other species, including non-mammalian taxa. In this article, we review behavioral neuroscientific experiments in non-mammalian species, including traditional “model organisms” (zebrafish and Drosophila) as well as in other species which can be used as “reference. ” The application of these domains in biological psychiatry and their translational relevance is considered.
Knowledge Management as a Service (KMaaS)

The issue of knowledge management is crucial for any organization. Convenient access to the requested content is creating a competitive advantage for different types of decisions. Today, when we are inundated with large volumes of information it is essential to use technological solutions that enable flexible storage, retrieval, processing and interpreting information. One of approach, which is communicated a few years, but it implementation is hampered by distrust are solutions based on cloud technology. Their potential grow particularly in an environment where individual skills are shared to a large number of users.
Endothelial Activation: The Ang/Tie Axis in Sepsis

Sepsis, a dysregulated host response to infection that causes life-threatening organ dysfunction, is a highly heterogeneous syndrome with no specific treatment. Although sepsis can be caused by a wide variety of pathogenic organisms, endothelial dysfunction leading to vascular leak is a common mechanism of injury that contributes to the morbidity and mortality associated with the syndrome. Perturbations to the angiopoietin (Ang)/Tie2 axis cause endothelial cell activation and contribute to the pathogenesis of sepsis. In this review, we summarize how the Ang/Tie2 pathway is implicated in sepsis and describe its prognostic as well as therapeutic utility in life-threatening infections.
A new sampling technique for association rule mining

Association Rule Mining (ARM) is one of the data mining techniques used to extract hidden knowledge from datasets, that can be used by an organization's decision makers to improve overall profit. However, performing ARM requires repeated passes over the entire database. Obviously, for large database, the role of input/output overhead in scanning the database is very significant. A popular solution to improve the speed of ARM is to apply the mining algorithm on a sample instead of the entire database. In this paper, a parameterized sampling algorithm for ARM is presented. This algorithm extracts sample datasets based on three parameters: transaction frequency, transaction length and transaction frequency-length. To evaluate its performance and accuracy, a comparison against a two-phase sampling-based algorithm is performed using real and synthetic datasets. The experimental results show that the proposed sampling algorithm in some cases outperforms two-phase sampling algorithm, and achieves up to 98% accuracy.
Treg(s) in Cancer: Friends or Foe?

Immune escape is a hallmark of cancer. Regulatory T cells (Treg) have been described to maintain peripheral tolerance. The role of Treg in cancer is ambiguous, as they are central inhibitory regulators in solid tumors, whereas during inflammation‐driven tumorigenesis they prevent cancer initiation by restraining inflammation. As a consequence, under conditions with chronic inflammation that may initiate malignant transformation, application rather than depletion of Treg may be helpful. In solid tumors, however, the success story of immune‐activating antibodies targeting checkpoint molecules of T cell activation fuels the hope that Treg inactivation or depletion may additionally boost anti‐tumor immune response. In this review we summarize important aspects on the dual role of Treg in cancer to provide a rationale for future Treg targeting attempts. J. Cell. Physiol. 9999: 2598–2605, 2015. © 2015 Wiley Periodicals, Inc.
04 Cavar_10.indd

The paper examines palatalization data from English, Polish and Croatian in the framework of Feature Geometry. It is shown that palatalization in the discussed data results in a number of phonologically diverse outputs, which cannot be accounted for by using one unique palatalization feature. Instead it is argued that palatalization can be represented by the spreading of either of two independent place specifications of the vowel, or of their combination. This approach implies a threefold typology of palatalization processes.
Retiming for wire pipelining in System-On-Chip

At the integration scale of System-On-Chips (SOCs), the conflicts between communication and computation will become prominent even on a chip. A big fraction of system time will shift from computation to communication. In synchronous systems, a large amount of communication time is spent on multiple-clock period wires. In this paper, we explore retiming to pipeline long interconnect wires in SOC designs. , Behaviorally, it means that both computation and communication are rescheduled for parallelism. The retiming is applied to a netlist of macro-blocks, where the internal structures may not be changed and flip-flops may not be able to be inserted on some wire segments. This problem is different from that on a gate level netlist and is formulated as a wire retiming problem. Theoretical treatment and a polynomial time algorithm are presented in the paper. Experimental results showed the benefits and effectiveness of our approach.
What is new in the pathophysiology of acne, an overview

Acne is a chronic inflammatory disease of the pilosebaceous unit. Its pathophysiology includes hyperseborrhoea, abnormal follicular keratinization and Propionibacterium acnes proliferation in the pilosebaceous unit. Recent research has shed some new light on the involvement of the sebaceous gland, as well as on the pro‐inflammatory activity of the cutaneous microbiome. During puberty, alteration of the sebaceous lipid profile, called dysseborrhoea, stress, irritation, cosmetics and potential dietary factors lead to inflammation and formation of different types of acne lesions. Dysbiosis, the process leading to a disturbed skin barrier and disequilibrium of the cutaneous microbiome, resulting in the proliferation of P. acnes strains, is another important process that triggers acne. P. acnes activates the innate immunity via the expression of protease activated receptors (PARs), tumour necrosis factor (TNF) α and toll‐like receptors (TLRs), and the production of interferon (INF) γ, interleukins (IL‐8, IL12, IL‐1), TNF, and matrix metalloproteinases (MMPs) by keratinocytes, resulting in the hyperkeratinization of the pilosebaceous unit. Rebalancing the natural microbiome of the skin by restoring the natural skin barrier, limiting the proliferation of P. acnes on the skin by using topical antibacterials which do not cause resistance and regulating quantity and quality of sebum will be the main acne treatment challenges in the future. The aim of this article to provide an update on the involvement of the sebaceous gland, the innate immunity and the cutaneous microbiome, how all of these factors promote acne and to illustrate their links with current and future treatments.
Public-key cryptography and password protocols

We study protocols for strong authentication and key exchange in asymmetric scenarios where the authentication server possesses ~a pair of private and public keys while the client has only a weak human-memorizable password as its authentication key. We present and analyze several simple password authentication protocols in this scenario, and show that the security of these protocols can be formally proven based on standard cryptographic assumptions. Remarkably, our analysis shows optimal resistance to off-line password guessing attacks under the choice of suitable public key encryption functions. In addition to user authentication, we describe ways to enhance these protocols to provide two-way authentication, authenticated key exchange, defense against server's compromise, and user anonymity. We complement these results with a proof that strongly indicates that public key techniques are unavoidable for password protocols that resist off-line guessing attacks. As a further contribution, we introduce the notion of public passwords that enables the use of the above protocols in situations where the client's machine does not have the means to validate the server's public key. Public passwords serve as "hand-held certificates" that the user can carry without the need for specal computing devices.
Stereotactic radiosurgery boost to the resection cavity for cerebral metastases: Report of overall survival, complications, and corticosteroid protocol

Background: This report focuses on the overall survival and complications associated with treatment of cerebral metastases with surgical resection followed by stereotactic radiosurgery (SRS). Management and complications of corticosteroid therapy are underreported in the literature but represent an important source of morbidity for patients. Methods: Fifty-nine consecutive patients underwent surgical resection of a cerebral metastasis followed by SRS to the cavity. Patient charts were reviewed retrospectively to ascertain overall survival, local control, surgical complications, SRS complications, and corticosteroid complications. Results: Our mean follow-up was 14.4 months (median 12.0 months, range 0.9-62.9 months). Median overall survival in this series was 15.25 months and local control was 98.3%. There was a statistically significant survival benefit conferred by Radiation Therapy Oncology Group recursive partitioning analysis Classes 1 and 2. The surgical complication rate was 6.8% while the SRS complication rate was 2.4%. Corticosteroid complications are reported and dependence at 1 month was 20.3%, at 3 months 6.8%, at 6 months 1.7%, and at 12 months no patients remained on corticosteroid therapy. Conclusions: Overall survival and local control with this treatment paradigm compare well to the other published literature. Complications associated with this patient population are low. A corticosteroid tapering protocol is proposed and demonstrated lower rates of steroid-related complications and dependence than previously reported.
Farnesol misplaces tip‐localized Rho proteins and inhibits cell wall integrity signalling in Aspergillus fumigatus

Farnesol is known for inducing apoptosis in some fungi and mammalian cells. To evaluate its potential role as an antifungal agent, we studied its impact on the human pathogen Aspergillus fumigatus. We found that growth of A. fumigatus wild type is inhibited, but two cell wall mutants, Δmnt1 andΔglfA, are much more susceptible to farnesol. This susceptibility is partially rescued by osmotic stabilization, suggesting that farnesol is a cell wall perturbing agent. However, farnesol does not activate but inhibit the cell wall integrity (CWI) pathway. Remarkably, mutants lacking AfMkk2 or AfMpkA, two kinases essential for CWI signalling, are also highly susceptible to farnesol, suggesting that its mode of action goes beyond inhibition of CWI signalling. Farnesyl derivatives are known for interfering with the function of prenylated proteins. We analysed the subcellular localization of two prenylated Rho family GTPases, AfRho1 and AfRho3, which are implicated in controlling CWI and the cytoskeleton. We found that under normal growth conditions AfRho1 and AfRho3 predominantly localize to the hyphal tip. After farnesol treatment this localization is rapidly lost, which is accompanied by swelling of the hyphal tips. Parallel displacement of tropomyosin from the tips suggests a concomitant disorganization of the apical actin cytoskeleton.
Short-Circuit Current Limitation Through 2G YBCO Resistive-Type SFCL Devices: A Model for Technical and Economic Comparison With Traditional Air-Core Reactors

In this paper, a methodology has been developed to perform techno-economic comparisons between superconducting fault current limiters (SFCL) devices and air-core reactors to be used for short-circuit current limitation following a parameterized approach. The methodology is based on the development of models dedicated to the SFCLs design, to the calculation of the electrical quantities in the grid under study, and to the economic analysis of the related costs. As an example of the developed methodology application, a parameterized study has been carried out with respect to the desired limitation and a comparison between SFCLs and air-core reactors installation in a test grid has been performed. In total, 30 different values of limitation factor have been fixed and, for each of them, design calculation of the device, its impact in the grid, both in steady-state and in transient regime, and the related economic analyses based on hypotheses of capital and operating costs (derived from the experience of Ricerca sul Sistema Energetico in the development and installation of resistive SFCL) have been carried out. The main outcome is that, for a given tariff plan, for a grid initial power factor and for a wide range of limitation factor values, it is possible that the installation of SFCL devices instead of air-core reactors may guarantee a time of return on investment shorter than ten years.
Membrane Performance Enhancement Using Electrically Conducting Membranes

Author(s): Duan, Wenyan | Advisor(s): Jassby, David | Abstract: Water shortage is a pervasive problem which has plagued societies for centuries. Recently, membrane technology has offered an effective and robust water treatment method for water sustainability due to great improvements in membrane performance. Depending on the intended applications, microfiltration (MF), ultrafiltration (UF), nano-filtration (NF) or reverse osmosis (RO) membranes can be used individually or in combination to achieve a specific water quality goal. However, a major challenge facing these technologies is membrane fouling, where particulates in the feed stream are deposited or developed on the membrane surface during the filtration process. Membrane fouling results in performance deterioration, lifetime shortening, and ultimately, increased operational costs. Therefore, membrane cleaning and fouling control or prevention are critical research topics for membrane development. The goal of this dissertation is to demonstrate fouling prevention and foulant removal on carbon nanotube-modified (CNT) electrically conductive UF, NF and RO membranes. First, mineral scaling was prevented and removed by applying an external anodic electrical potential to an electrically conducting CNT – polyamide RO membrane. The results demonstrate that CaCO3 scaling was efficiently removed by the intermittent application of 2.5V and CaSO4 scaling can be prevented by the continuous application of 1.5V with the membrane as the anode. Second, biofouling and organic fouling were prevented while treating anaerobic sequencing batch reactor effluent by using electrically conducting UF and NF membranes. The continuous application of negative 5V to the UF membrane surface prevents organic fouling and allows good membrane performance while treating complex wastewater streams for long periods of time. The application of positive potentials to the NF membranes has also been shown to increase fouling and hinder cleaning and recovery. Third, a highly conductive and anodically stable polyaniline coated UF membrane was designed and used as a flow through electrode. Results show that the polyaniline coated CNT membrane had a significantly reduced degradation rate under high anodic potentials in a pH controlled environment when compared with polyvinyl alcohol crosslinked CNT membrane. The modified membrane can be used to degrade organic compounds and perform in situ oxidative cleaning of the fouled membrane without any additional oxidizing chemical reagents.
Antibiotics Shaping Bacterial Genome: Deletion of an IS91 Flanked Virulence Determinant upon Exposure to Subinhibitory Antibiotic Concentrations

The nucleoid-associated proteins Hha and YdgT repress the expression of the toxin α-hemolysin. An Escherichia coli mutant lacking these proteins overexpresses the toxin α-hemolysin encoded in the multicopy recombinant plasmid pANN202-312R. Unexpectedly, we could observe that this mutant generated clones that no further produced hemolysin (Hly-). Generation of Hly- clones was dependent upon the presence in the culture medium of the antibiotic kanamycin (km), a marker of the hha allele (hha::Tn5). Detailed analysis of different Hly- clones evidenced that recombination between partial IS91 sequences that flank the hly operon had occurred. A fluctuation test evidenced that the presence of km in the culture medium was underlying the generation of these clones. A decrease of the km concentration from 25 mg/l to 12.5 mg/l abolished the appearance of Hly- derivatives. We considered as a working hypothesis that, when producing high levels of the toxin (combination of the hha ydgT mutations with the presence of the multicopy hemolytic plasmid pANN202-312R), the concentration of km of 25 mg/l resulted subinhibitory and stimulated the recombination between adjacent IS91 flanking sequences. To further test this hypothesis, we analyzed the effect of subinhibitory km concentrations in the wild type E. coli strain MG1655 harboring the parental low copy number plasmid pHly152. At a km concentration of 5 mg/l, subinhibitory for strain MG1655 (pHly152), generation of Hly- clones could be readily detected. Similar results were also obtained when, instead of km, ampicillin was used. IS91 is flanking several virulence determinants in different enteric bacterial pathogenic strains from E. coli and Shigella. The results presented here evidence that stress generated by exposure to subinhibitory antibiotic concentrations may result in rearrangements of the bacterial genome. Whereas some of these rearrangements may be deleterious, others may generate genotypes with increased virulence, which may resume infection.
Covariance matrices with prescribed null entries

For a Gaussian random vector X with covariance matrix K, two distinct components Xi and Xj are marginally independent if and only if Ki,j = 0. In these notes, we consider the maximum likelihood estimation of the covariance matrix K under the constraint that K has some prescribed null entries. This estimation problem arise in many applied contexts, and is often fully addressed only when the pattern of prescribed zeroes for K has a simple structure, e.g. K has a block diagonal structure for instance. In these notes, we do not use any simplified structural assumptions on the pattern of zeroes.
Diagnostic Accuracy of Cerebrospinal Fluid Gram Stain in Children With Suspected Bacterial Meningitis

This cross-sectional study included 1938 children undergoing lumbar puncture; 21 (1.1%) cases were classified as definite (n = 17) or probable (n = 4) bacterial meningitis. Gram stain sensitivity was 94.1% (95% confidence interval, 71.3%–99.9%) for those with definite meningitis; the positive predictive value was 47.1% (95% confidence interval, 29.8%–64.9%). The sensitivity was 95.2% for those with definite or probable meningitis. Antibiotic pretreatment did not affect results.
Identification of a novel homozygous ALX4 mutation in two unrelated patients with frontonasal dysplasia type‐2

We report two unrelated boys with frontonasal dysplasias type‐2 (FND‐2) who shared an identical novel homozygous ALX4 mutation c.291delG (p.Q98Sfs*83). Both patients presented with a large skull defect but one had bilateral parietal meningocele‐like cysts that lie along with the bony defect and increased in size with age. Scalp alopecia, hypertelorism, and clefted alae nasi were also detected in both of them. Furthermore, impalpable gonads were noted, being unilateral in one and bilateral in the other. Neuroimaging showed small dysplastic occipital lobes with dysgyria and midline subarachnoid cyst. Additional dysplastic corpus callosum and small cerebellar vermis were observed in one patient. Parietal foramina were noted in the parents of one patient. Our findings highlight the dosage effect of ALX4 and underscore the challenges of prenatal genetic counseling. Further, the indirect role of ALX4 in the development of the occipital lobe and posterior fossa is discussed.