Miracle-dz/UniFAR-FTUs huggingface dataset:
More exhausted doctors - what to do?

Over a number of years it has been reported that American doctors are increasingly affected by the phenomenon referred to as ’burnout’ (1). Studies show that a little more than 50 % of all American doctors indicate that they are affected in at least one of the three dimensions of burnout: exhaustion, cynicism and reduced work effectiveness (2, 3). This is reported to be significantly higher than in other groups of American professionals, and a documented increase occurred in the group of doctors from 2011 to 2014 (3).
Psychoanalytic psychotherapy and the tragic sense of life and death

The authors discuss the role of psychotherapy with dying patients and exploree the psychological impact of imminent death. The psychotherapy case they present highlights the symbolic meaning of fatal symptoms end the light this meaning sheds on the relationship between how we live and how we die. These features are addressed in the context of larger unresolved clinical issues: Is there a «healthy» way to die ? And is there a unique role for psychoanalytic psychotherapy with dying patients ? (Bulletin of the Menninger Clinic, 59[2], 145-159)
Centralized Cooperative Directional Spectrum Sensing for Cognitive Radio Networks

Most previous spectrum sensing techniques use omni-directional antennas. Unlike omni-directional antennas, the use of directional antennas for spectrum sensing is a promising technique that can realize fine-grained sensing for the primary user (PU) with a longer sensing range. In this paper, we propose a centralized cooperative directional sensing technique for cognitive radio networks. We assume that one secondary coordinator called the fusion center (FC), gathers sensing results from secondary nodes. Using the reported information, the FC optimizes the sensing period, sensing power, and sensing beams per secondary node. For optimization, we use a modified gradient descent method with numerical methods to solve the nonlinear optimization problem. The simulation results show that our directional spectrum sensing technique is well suited for the existing cognitive radio environment. The optimal scheme shows proposed here better performance in all simulation factors than the non-optimized scheme.
Stream Reasoning for the Internet of Things: Challenges and Gap Analysis

The Internet of Things (IoT) is not only about interconnecting embedded devices to the Internet, but also about providing knowledge on such devices and what they sense from the physical world. One focus of IoT is put on extracting actionable knowledge and providing value-added services by means of reasoning techniques. Stream reasoning techniques offer a promising solution for processing dynamic, heterogeneous, and volume data for IoT. In this article, we identify the challenges for utilizing stream reasoners from the IoT point of view, review the landscape of stream reasoning techniques, and examine their capabilities to meet the challenges of IoT. Moreover, we present an experimental IoT system implementing stream reasoning and perform a gap analysis to evaluate stream reasoners. Finally, based on the analysis, we suggest several recommendations for future development of stream reasoners in order to overcome the identified gaps.
Violent men. An inquiry into the psychology of violence. Aldine Publishing Company, Chicago 1969, XVII und 268 Seiten

Chronic predatory offenders, problem police officers, and others with a demonstrated propensity for violent conduct are the concern of Violent Men: An Inquiry Into the Psychology of Violence. This revised edition explores the personal motives, attitudes, assumptions, and perceptions of men who are recurrently violent. How patterned and consistent is the violence of such men? What are the dynamics of their escalating encounters? What personal dispositions and orientations are most apt to lead to violence? Readers will not only discover insightful scholarly research, but sense the humanity of violent men, as well as their uniqueness.
The level of observed physical movement accompanying periodic limb movements measured in a clinical sleep population

Study objectives Periodic limb movements (PLMs) are routinely measured during polysomnogram (PSG) testing. During the early years of sleep testing, physical movements were identified and over time, consensus ultimately led to the current definitions of movement disorders including criteria used to measure PLMs on PSG testing. There has been considerable debate about the clinical importance of the PLMs measured during PSG testing. Over the last decade, the author has observed significant variations in the actual visible physical movements observed with a PLM event. This report is the result of work to quantify the amount of movement and the frequency of movements observed among individuals who have PLMs. Methods/principal findings Consecutive PSGs performed in a suburban sleep center for an initial diagnosis of a sleep disorder were retrospectively reviewed to identify those with measured PLMs. Of 646 studies on patients >18 years, 460 met criteria for inclusion. Visual assessment of movements was carried out on all of those with PLM events measured using American Academy of Sleep Medicine guidelines. The movements were quantified based on the number of extremities observed to move. PLMs were observed in 237 of the 460 studies that met inclusion criteria (52%). As expected, the PLMs occurred more frequently in older individuals. PLMs occurred with equal frequency in both sexes. Apnea occurred with equal frequency in those with and without observed physical movements. Of those with PLMs, 62% (147) demonstrated observable physical movements. Significant movements involving three or four extremities occurred in 16% of individuals with PLMs. No physical movements were observed in 38%. Conclusion In this uncontrolled, nonrandom, observational series, visual physical movements with a PLM event identify a unique subset of individuals with PLMs. The presence of any visual movements or more pronounced visual movements involving multiple extremities may represent markers for PLM disorder, for clinically significant PLMs with other disorders, or for other clinical conditions or physiologic variables.
Effectiveness of Multi-strain Versus Single-strain Probiotics: Current Status and Recommendations for the Future

Probiotics are investigated as single-strain and multistrain products. In the market, however, there is an increasing tendency to work with multistrain probiotics, in particular, products with a high number of different strains. There are some thoughts behind this: more strains imply more chances of success; it can mean a broader spectrum of efficacy, and there is often the hope that there are at least additive and, potentially, even synergistic effects. The present review did not find convincing evidence that these assumptions are valid. There is, however, also no strong evidence that the assumptions are incorrect and/or that there is antagonistic activity between strains in a combination. We suggest that, to answer these questions, structured research is conducted. Starting with a systematic review of meta-analyses that have compared single-strain and multistrain probiotic efficacy, dedicated human studies need to be performed, comparing single-strain and multistrain probiotics to each other and placebo. In vitro and animal studies can provide indications and may help understand mechanisms. For human, animal, and in vitro studies, it is recommended to work with the simple setup of 2 single strains, a 2-strain combination, and placebo. It is also important in such research to take into consideration the doses, as a combination product will have a higher total dose.
Chapter 8 Interplay Between Sibling Bacterial Colonies

Bacteria in the wild are frequently exposed to harsh conditions, the sources of which include, but are not limited to, a lack of available nutrients, overcrowding and space limitations, the presence of enemies, and extreme environmental conditions, such as high temperatures and dryness. Their responses to stress can consist of radical behaviors, such as the deadly competition often observed between individuals of the same species [1–5]. The first and most fundamental of all organisms, bacteria have evolved mechanisms to ensure their survivability when faced with harsh conditions [6, 13]. They lead rich social lives in complex hierarchical communities, collectively sense the environment to glean information, learn from past experience, and make decisions. To engage in such complex, cooperative behavior, bacteria utilize highly sophisticated chemical communication mechanisms whose chemical language includes semantic and even pragmatic aspects [7].
Chronic Stress protection for postnatal dEpREssioN prEvention (SERENE): a protocol for an exploratory study

Introduction The prevalence of postnatal depression (PND) is significant: reaching up to 20% in the general population. In mechanistic terms, the risk of PND lies in an interaction between a maternal psychophysiological vulnerability and a chronic environmental context of stress. On the one hand, repetition of stressor during pregnancy mimics a chronic stress model that is relevant to the study of the allostatic load and the adaptive mechanisms. On the other hand, vulnerability factors reflect a psychological profile mirroring mindfulness functioning (psychological quality that involves bringing one’s complete and non-judgemental attention to the present experience on a moment-to-moment basis). This psychological resource is linked to protective and resilient psychic functioning. Thus, PND appears to be a relevant model for studying the mechanisms of chronic stress and vulnerability to psychopathologies. In this article, we present the protocol of an ongoing study (started in May 2017). Methods and analysis The study is being carried out in five maternities and will involve 260 women. We aim to determine the predictive psychobiological factors for PND emergence and to provide a better insight into the mechanisms involved in chronic stress during pregnancy. We use a multidisciplinary approach that encompasses psychological resources and biophysiological and genetic profiles in order to detect relevant vulnerability biomarkers for chronic stress and the development of PND. To do so, each woman will be involved in the study from her first trimester of pregnancy until 12 months postdelivery. Ethics and dissemination Ethics approval was obtained from the Ile de France III Ethics Committee, France (2016-A00887-44). We aim to disseminate the findings through international conferences and international peer-reviewed journals. Trial registration number NCT03088319; Pre-results.
Dynamic Neuro-Cognitive Imagery Improves Mental Imagery Ability, Disease Severity, and Motor and Cognitive Functions in People with Parkinson's Disease

People with Parkinson's disease (PD) experience kinesthetic deficits, which affect motor and nonmotor functions, including mental imagery. Imagery training is a recommended, yet underresearched, approach in PD rehabilitation. Dynamic Neuro-Cognitive Imagery (DNI™) is a codified method for imagery training. Twenty subjects with idiopathic PD (Hoehn and Yahr stages I–III) were randomly allocated into DNI training (experimental; n = 10) or in-home learning and exercise program (control; n = 10). Both groups completed at least 16 hours of training within two weeks. DNI training focused on anatomical embodiment and kinesthetic awareness. Imagery abilities, disease severity, and motor and nonmotor functions were assessed pre- and postintervention. The DNI participants improved (p < .05) in mental imagery abilities, disease severity, and motor and spatial cognitive functions. Participants also reported improvements in balance, walking, mood, and coordination, and they were more physically active. Both groups strongly agreed they enjoyed their program and were more mentally active. DNI training is a promising rehabilitation method for improving imagery ability, disease severity, and motor and nonmotor functions in people with PD. This training might serve as a complementary PD therapeutic approach. Future studies should explore the effect of DNI on motor learning and control strategies.
Usefulness of 18F-FDG PET/CT for evaluating response of ocular adnexal lymphoma to treatment

Abstract The purpose of this study was to investigate the efficacy of 18F-fluoro-deoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for evaluating the ocular adnexal lymphoma treatment responses. We retrospectively reviewed data for 9 histologically confirmed cases of malignant lymphoma. All patients had at least one ocular adnexal tumor site and underwent FDG PET/CT before and after treatment. Patients’ histological disease subtypes included diffuse large B-cell lymphoma (n = 3), mucosa-associated lymphoid tissue lymphoma (n = 2), follicular lymphoma (n = 1), NK/T-cell lymphoma (n = 1), lymphoplasmacytic lymphoma (n = 1), and Hodgkin lymphoma (n = 1). The highest FDG uptake by the ocular adnexal lesions was calculated as the maximum standardized uptake value (SUVmax). FDG uptake at ocular adnexal sites and sites of systemic disease after treatment were also assessed using the 5-point Deauville scale. In 1 of the 9 patients, a conjunctival lesion could not be detected by either pre- or posttreatment PET/CT. For 8 of the 9 patients, the SUVmax value at the ocular adnexal site significantly decreased after treatment (7.1 ± 5.1 vs 1.6 ± 0.58; P = .0196). For 7 of the 9 patients, the first posttreatment FDG uptake at the ocular adnexal site was considered a complete metabolic response, and these patients showed an improved clinical ophthalmic presentation with no relapse at ocular adnexal sites during follow-up. FDG PET/CT is useful for evaluation of the response of ocular adnexal lymphoma to treatment, although its usefulness may depend on the histological subtype and site of the lesion.
Wearable Technology for Chronic Wound Monitoring: Current Dressings, Advancements, and Future Prospects

Chronic non-healing wounds challenge tissue regeneration and impair infection regulation for patients afflicted with this condition. Next generation wound care technology capable of in situ physiological surveillance which can diagnose wound parameters, treat various chronic wound symptoms, and reduce infection at the wound noninvasively with the use of a closed loop therapeutic system would provide patients with an improved standard of care and an accelerated wound repair mechanism. The indicating biomarkers specific to chronic wounds include blood pressure, temperature, oxygen, pH, lactate, glucose, interleukin-6 (IL-6), and infection status. A wound monitoring device would help decrease prolonged hospitalization, multiple doctors' visits, and the expensive lab testing associated with the diagnosis and treatment of chronic wounds. A device capable of monitoring the wound status and stimulating the healing process is highly desirable. In this review, we discuss the impaired physiological states of chronic wounds and explain the current treatment methods. Specifically, we focus on improvements in materials, platforms, fabrication methods for wearable devices, and quantitative analysis of various biomarkers vital to wound healing progress.
Measurement and control of human movement

For the purpose of real-time investigation of human motion in which feedback during a movement must be possible, various optoelectronic techniques for non-contacting motion studies have been compared. Light sources and detectors for singleand dual-axis position measurement are discussed, with special emphasis on multiple light spot sensing. An experimental system based upon one of these detectors is described, and some preliminary results on timing and coordination of human motion are presented.
Living in Media and the Future of Advertising

The future role of advertising and its professionals in society is considered using media theory and the production perspective on advertising as work. Given advertising's reliance on media to tell its stories, and people's everyday lives playing out within those same media, the moment these worlds collide provides an excellent starting point for futuristic exploration. Using a taxonomy of media as artifacts, activities, and social arrangements, advertising is considered in terms of an aesthetic opportunity, an ethical call to action, and a social responsibility.
Protective Effects of IMOD and Cimetidine against Radiation-induced Cellular Damage

Radiation damage is to a large extent caused by overproduction of reactive oxygen species (ROS). Radioprotectors are agents or substances that reduce the effects of radiation in healthy normal tissues while maintaining the sensitivity to radiation damage in tumor cells. Radioprotectors are agents or substances that reduce the effects of radiation in healthy normal tissues while maintaining the sensitivity to radiation damage in tumor cells Cimetidine was found more effective when used in vivo; this effect might be due to the augmentation of the presence of Sulphur atom in the compound which is ýimportant for their scavenging activity. Recently, a new herbal-based medicine with immunomodulatory capacities, Setarud (IMOD), was introduced as an additional therapy in various inflammatory diseases and HIV infection. IMOD is a mixture of herbal extracts enriched with selenium. Selenium confers protection by inducing or activating cellular free-radical scavenging systems and by enhancing peroxide breakdown. This article suggests that nontoxic amount of IMOD and cimetidine have radioprotective properties and could reduce cytotoxic effects of radiation.
Management of cancer‐associated thrombosis in patients with thrombocytopenia: guidance from the SSC of the ISTH

B . T . SAMUELSON BANNOW,* A . LEE ,† A. A . KHORANA,‡ J . I . ZWICKER ,§ S . NOBLE , ¶ C. AY** and M. CARR IER†† *Department of Medicine, Division of Hematology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA; †Division of Hematology, Department of Medicine, University of British Columbia, British Columbia Cancer Agency, Vancouver, British Columbia, Canada; ‡Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH; §Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; ¶Marie Curie Palliative Care Research Centre, Cardiff University, Cardiff, UK; **Department of Medicine I, Clinical Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria; and ††Department of Medicine, Ottawa Hospital Research Institute at the University of Ottawa, Ottawa, Ontario, Canada
Association between Organochlorine Pesticide Levels in Breast Milk and Their Effects on Female Reproduction in a Taiwanese Population

Only few studies have focused on organochlorine pesticides (OCPs) in breast milk and the related health risks for women in Taiwan. Our goal is to examine breast milk OCPs and their associations with female reproductive function (infertility, gynecological diseases, and menstruation characteristics) as well as their correlation with sociodemographic parameters (age, pre-pregnant body mass index (BMI), annual incomes, population, birth year, and parity) and dietary habit. The breast milk samples were collected in southern Taiwan (n = 68) from 2013 to 2016 and the OCP residues were analyzed using high resolution gas chromatography with low resolution mass spectrometry (HRGC/LRMS). The results show that the most abundant OCP residues in the breast milk was ΣDDT with the geometric mean ± standard deviation of 9.81 ± 7.52 ng−1 lipid−1 followed by ΣHCH (0.539 ± 0.557 ng−1·lipid−1). In the principal component analysis, cis-chlordane (cis-CHL) and γ-HCH were found to be related to participants who received medical treatment for infertility, and 4,4′-DDT was associated with those who received gynecological surgery. The logistic regression showed that the odds ratio (OR) of log γ-hexachlorocyclohexane (γ-HCH) was higher for mothers who had received medical treatment for infertility than for the normal group (OR = 25.6, p = 0.035) after adjustments for age, pre-pregnant BMI, annual income, population (i.e., native-born Taiwanese), birth year, and parity. Cow milk and beef consumption as well as menstruation characteristics such as average menstrual period (>5 days), shortest menstrual period (<3 days), and women who had taken hormonal drugs were significantly associated to several OCP residues in the breast milk. In addition, ΣHCH including β-HCH and γ-HCH was correlated with annual family income and gravidity as well as cow milk and beef consumptions. Overall, γ-HCH exhibited a probable association with the infertility diseases of Taiwanese women, and dietary habit might play an important role in the female Taiwanese exposure to OCPs.
Perceived body orientation in microgravity: effects of prior experience and pressure under the feet.

UNLABELLED Human activities often involve sensing body orientation using cues from gravity. Astronauts in microgravity are deprived of those cues and may have difficulty with certain tasks. We theorized that experience in microgravity combined with mechanically induced pressure under the feet (foot pressure) would improve the accuracy of a subject's perception of the body's z-axis as indicated by pointing to the subjective horizon (SH). METHOD Experiments were conducted during parabolic flights using five experienced subjects and five novices. Subjects were required to raise their arm to point to their SH with eyes closed. Measurements were made on Earth and in microgravity, with or without foot pressure. Both pointing accuracy and the kinetics of the movement were analyzed. RESULTS Performance by experts was stable under all conditions. However, novices in microgravity pointed to a significantly lower SH (16.5 degrees below the 1-G SH) and slowed their movements (mean angular velocity of movement: 16.8 degrees x s(-1) less than in 1 G). Foot pressure improved the performance of the novices so that it was closer to that observed at 1 G (8.9 degrees below the 1-G SH). DISCUSSION These results suggest that pressure cues under the feet activated the internal model of gravity in the novices, and thus improved the accuracy of their perception of their z-axis. Subjects with prior experience in microgravity correctly perceived their z-axis without the supplementary input.
Extracellular vesicles in mesenchymal stromal cells: A novel therapeutic strategy for stroke

A stroke is a focal cerebral insult that frequently causes severe neurological deficit and mortality. Recent studies have demonstrated that multipotent mesenchymal stromal cells (MSCs) hold great promise for neurovascular remodeling and neurological function recovery following a stroke. Rather than a direct replacement of parenchymal brain cells, the therapeutic mechanism of MSCs is suggested to be the secretion of soluble factors. Specifically, emerging data described MSCs as being able to release extracellular vesicles (EVs), which contain a variety of cargo including proteins, lipids, DNA and various RNA species. The released EVs can target neurocytes and vascular cells and modify the cell's functions by delivering the cargo, which are considered to mediate the neural restoration effects of MSCs. Therefore, EVs may be developed as a novel cell-free therapy for neurological disorders. In the present review, the current advances regarding the components, functions and therapeutic potential of EVs are summarized and the use of MSC-derived EVs as a promising approach in the treatment of stroke are highlighted.