Miracle-dz/UniFAR-FTUs huggingface dataset:
The Role of Endoscopy and Biopsy in Evaluating Preneoplastic and Particular Gastric Lesions

Although incidence has declined in recent years, gastric cancer still represents the second most frequent cause of cancer-related mortality in the world [1]. The prognosis of stom‐ ach cancer is related to the stage of disease at the time of diagnosis, with a good progno‐ sis associated with early gastric cancer [2]. Therefore, it is essential an early diagnosis of gastric carcinoma, at present only about 10-20% of cancers being diagnosed in an early phase [3]. A great interest has arisen in recent years in the detection and management of premalignant conditions and early gastric cancer because of the high cure rate achieved treating these lesions, compared with advanced gastric cancer. The well known multistep cascade of carcinogenesis developed by Correa [4] is represented by superficial gastritis followed by atrophic gastritis, intestinal metaplasia and increasing grades of dysplasia, leading to gastric adenocarcinoma. Surveillance of the premalignant lesions could deter‐ mine an early detection of patients with disease progression, with the possibility of early therapeutic intervention and improved survival of these patients [5].
Top Management Team Demography and Process: The Role of Social Integration and Communication

Examines the effect of team demography on firm performance. Three models of team demography, process, and firm performance are considered: direct demography, process, and the intervening model. The demography model, which holds that team demography is the sole determinant of performance outcomes, is modeled in terms of heterogeneity, team tenure, and team size. The process model, which purports that demography and process contribute separately to performance outcomes, measures demography in the same terms as the demography model and measures process in terms of social integration, informal communication, and communication frequency. The intervening model proposes that team demography affects team process and in turn influences process. Data were collected from 53 U.S. high-technology firms, through interviews and surveys of the firm CEOs and their top management teams. The results show little support for the demography model, while partial support is shown for the intervening model. Team process is shown to have a direct impact on performance while demography is shown to have direct and indirect effects. These results indicate that keeping team size small enhances informal communication and social integration. It is evidence that the relationship between team demography, process and performance is not straightforward. (SRD)
Application of DNA barcodes in wildlife conservation in Tropical East Asia

Over the past 50 years, Tropical East Asia has lost more biodiversity than any tropical region. Tropical East Asia is a megadiverse region with an acute taxonomic impediment. DNA barcodes are short standardized DNA sequences used for taxonomic purposes and have the potential to lessen the challenges of biodiversity inventory and assessments in regions where they are most needed. We reviewed DNA barcoding efforts in Tropical East Asia relative to other tropical regions. We suggest DNA barcodes (or metabarcodes from next‐generation sequencers) may be especially useful for characterizing and connecting species‐level biodiversity units in inventories encompassing taxa lacking formal description (particularly arthropods) and in large‐scale, minimal‐impact approaches to vertebrate monitoring and population assessments through secondary sources of DNA (invertebrate derived DNA and environmental DNA). We suggest interest and capacity for DNA barcoding are slowly growing in Tropical East Asia, particularly among the younger generation of researchers who can connect with the barcoding analogy and understand the need for new approaches to the conservation challenges being faced.
Simple Procedure for Rapid Identification of Vibrio cholerae from the Aquatic Environment

ABSTRACT Biochemical tests commonly used to screen for Vibrio cholerae in environmental samples were evaluated, and we found that a combination of alkaline peptone enrichment followed by streaking on thiosulfate citrate bile salts sucrose agar and testing for arginine dihydrolase activity and esculin hydrolysis was an effective rapid technique to screen for aquatic environmental V. cholerae. This technique provided 100% sensitivity and ≥70% specificity.
Organizational Mediation of Project-Based Labor Markets: Talent Agencies and the Careers of Screenwriters

We examine how organizations that mediate “life-of-project” employment segment the labor market in a culture industry. Using longitudinal data on writers for television and feature films, we examine trends in the extent to which type of agency representation affects writers’ employment and earnings. Elite or “core “ agencies are those that transcend their role as market brokers between the suppliers and purchasers of writing services by participating actively in the production process. Writers who are represented by such agencies are substantially more likely to find employment, and they earn considerably more than equally accomplished writers with noncore agency representation. We discuss the implications of these findings for contingent employment of professionalized employees in other highly institutionalized industrial sectors.
Effects of growth conditions on the resistance of some pathogenic and spoilage species to high pressure homogenization

R. LANCIOTTI, F. GARDINI, M. SINIGAGLIA AND M.E. GUERZONI. 1996. The effects of chemicophysical growth conditions such as pH, temperature and water activity (aw) on lethal high homogenization pressure effects on Listeria monocytogenes, Staphylococcus aureus, Escherichia coli and Yarrowia lipolytica were investigated. The results, though based on standard media, emphasize the importance of food system composition and its thermal history on the high pressure tolerance of the microbial population.
Effect of pH on phytoplankton and bacteria production

In recent decades eutrophication has fueled intense phytoplankton blooms that frequently negatively impact ecosystems. Dramatic pH elevations are commonly overlooked during such blooms, which may also be harmful. Cyanobacteria blooms in the Sassafras River, MD were sampled during Autumn 2008 and measured for primary and bacterial production (PP and BP), and differences in bacteria communities composition were examined. pH elevations above 8.8 in the field corresponded to decreased PP, but had no effect on BP. Laboratory experiments demonstrated that negative effects of pH were dependant on light intensity; PP increased with pH at moderate light intensities, but decreased at low irradiance. There was some evidence that BP is affected by high pH, although bacteria community differences as determined by DGGE were not. Negative effects of high pH are probably most important during spring and summer in low salinity environments when pH fluctuations are more common and last longer.
Enhancement of tumor initiation and expression of KCNMA1, MORF4L2 and ASPM genes in the adenocarcinoma of lung xenograft after vorinostat treatment

Cancer stem cells (CSCs) are usually tolerant to chemotherapy and radiotherapy and associated with tumor relapse. Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor (HDACI), is currently being used in clinical trials of lung cancer. However, SAHA facilitates the formation of induced pluripotent stem cells from somatic cells. We hypothesized that SAHA would mediate the CSCs properties and subsequently confer a more malignant phenotype in lung cancer. Transfected H1299 lung cancer cells, which stably expresses a triple fused reporter gene (DsRedm-Fluc-tTKsr39) under the control of CMV promoter was used to establish a xenograft mouse model. After the treatment of SAHA, H1299 cell line and tumor xenografts were sorted by fluorescence-activated cell sorting (FACS) based on aldehyde dehydrogenase (ALDH) activity. We found that SAHA could suppress the growth of xenografted H1299 tumors with decreased proportion of ALDHbr lung cancer cells indicating that SAHA may target CSCs. However, SAHA significantly enhanced the tumor initiating capacity and the expression of malignant genes such as KCNMA1, MORF4L2 and ASPM in the remaining living ALDHbr cells. These findings suggested that SAHA treatment created a more drug-resistant state in residual ALDHbr cells. The in vivo imaging technique may facilitate searching and characterization of CSCs.
Effect of Positive Inotropic Agents on the Relation between Oxygen Consumption and Systolic Pressure Volume Area in Canine Left Ventricle

We analyzed the effect of positive inotropic agents on the relation between left ventricular oxygen consumption and the systolic pressure-volume area. Pressure-volume area is a measure of total mechanical energy for ventricular contraction, and is a specific area in the ventricular pressure-volume diagram circumscribed by the end-systolic and end-diastolic pressure- volume relation curves and the systolic segment of the pressure-volume trajectory. Either epinephrine (1 μg/kg per min, iv) or calcium ion (0.03 mEq/kg per min, iv) was administered to canine excised cross-circulated hearts. These agents increased an index of ventricular contractility, Emax, or the slope of the end-systolic pressure-volume line, by 70%. The regression lines of ventricular oxygen consumption on pressure-volume area in control and in enhanced contractile states were of the same formula: ventricular oxygen consumption (ml 02/beat per 100 g) equals A times pressure-volume area (mm Hg ml/beat per 100 g) plus a constant B. Coefficient A remained unchanged at 1.8 × 10∼5 ml oxygen/(mm Hg ml), but constant B increased from 0.03 ml oxygen/beat per 100 g by more than 50% with either agent. The reciprocal of A reflects the energy conversion efficiency for the total mechanical energy, and this efficiency remained near 36%. The increase in B was equal to the directly measured increment in ventricular oxygen consumption for mechanically unloaded contraction. The basal metabolism remained unchanged. We conclude that the augmented oxygen consumption under the acutely enhanced contractile state with either epinephrine or calcium was caused primarily by an increased energy utilization associated with the excitation-contraction coupling.
Diagnostic Reasoning and Decision Making in the Context of Health Information Technology

Diagnostic reasoning and medical decision making have been focal areas of research in the fields of medical education, cognition, and artificial intelligence in medicine. Drawing on several decades worth of research, we propose an integrated summary of prior research on diagnostic reasoning and decision making—in terms of both historical development and theoretical shifts. We also characterize the changes in research and theory resulting from the incorporation and adoption of health information technology in the clinical work place. In this paper, we differentiate between the various forms of diagnostic reasoning and trace the evolution of the various models of reasoning, including knowledge-based, exemplar-based, and visual strategies. We also discuss the effect of clinical expertise on reasoning processes. Within the medical decision-making research, we delineate the various approaches highlighting decision-making errors that arise due to the nature of heuristics and biases and other factors. Although t.
Identification of a retinoic acid‐responsive neural enhancer in the Ciona intestinalis Hox1 gene

The Hox1 gene in the urochordate ascidian Ciona intestinalis (Ci‐Hox1) is expressed in the nerve cord and epidermis. We identified a nerve cord enhancer in the second intron of Ci‐Hox1, and demonstrated that retinoic acid (RA) plays a major role in activating this enhancer. The enhancer contained a putative retinoic acid‐response element (RARE). Mutation of the RARE in the Ci‐Hox1 nerve cord enhancer only partially abolished the enhancer activity. Genes encoding RA synthase and the RA receptor were knocked down using specific antisense morpholino oligos (MOs), and injection of embryos with these MOs resulted in the complete disappearance of epidermal expression of Ci‐Hox1 and reduction of neural expression. However, nerve cord expression was not completely repressed. These results suggest that the nerve cord enhancer is activated by two partially redundant pathways; one RA‐dependent and one RA‐independent.
Reinjury prevention follow-through for clients with cumulative trauma disorders.

OBJECTIVES Fifteen subjects with upper extremity work-related cumulative trauma disorders were involved in a quality improvement study to determine their self-reported degree of follow-through with reinjury prevention regimens. The effect of cuing was also studied. METHOD During occupational therapy, subjects were involved in an educational session that focused on recommendations in ergonomic equipment, therapeutic maintenance techniques, body mechanics, and work simplification techniques. Follow-through with reinjury prevention education was evaluated and rated via telephone interviews approximately 2 weeks (T1) and 4 weeks (T2) after the educational session. Subjects did not know the questions they would be asked at T1, but were cued that their progress would be checked again at T2. Dependent t tests were conducted to compare the mean number of recommendations for which complete follow-through was expected with the mean number of recommendations at T1 and T2 that were implemented completely. RESULTS A significantly lower degree was found of absolute completion of recommendations at T1 and T2 than had been anticipated (p < .002). No significant difference between T1 and T2 was found, indicating that cuing at T1 had little effect on subjects' actual follow-through rate. CONCLUSION The implications of these findings for occupational therapists support the need for further research in reinjury prevention and employer education.
Environmental and policy determinants of physical activity in the United States.

OBJECTIVES This study examined (1) descriptive patterns in perceived environmental and policy determinants of physical activity and (2) associations between these factors and behavior. METHODS A cross-sectional study was conducted from 1999 to 2000 among US adults; individuals at lower income levels were oversampled. RESULTS Availability of areas for physical activity was generally higher among men than among women. The 4 most commonly reported personal barriers were lack of time, feeling too tired, obtaining enough exercise at one's job, and no motivation to exercise. Neighborhood characteristics, including the presence of sidewalks, enjoyable scenery, heavy traffic, and hills, were positively associated with physical activity. There was a high level of support for health policy-related measures. Up to one third of individuals who had used environmental supports reported an increase in physical activity. CONCLUSIONS An array of environmental and policy determinants, particularly those related to the physical environment, are associated with physical activity and should be taken into account in the design of interventions.
Increased ischemia-reperfusion blood flow impairs the skeletal muscle contractile function.

BACKGROUND The ultimate aim of replantations and transplantations of skeletal muscle is to improve impaired function. The purpose of this study was to examine the contribution of varying durations of ischemia to postischemic blood flow in the skeletal muscle and the contribution of modulation of postischemic blood flow to skeletal muscle function and viability, using an ischemic revascularized hind limb model in rats. MATERIALS AND METHODS Warm ischemia produced by vascular pedicle clamping was sustained for 90 min, 3 h, or 6 h. Postischemic blood flow was measured by a Doppler flowmeter or microsphere technique. In another series of experiments of 3-h ischemia, either saline or N(G)-methyl-l-arginine acetate (l-NMMA) was infused for the first 2 h of reperfusion. Postischemic blood flow was also measured. Muscle contractile function and viability were determined after 24 h of reperfusion. RESULTS Postischemic blood flow was significantly increased during the first 10 min of reperfusion in the 90-minute ischemic group and during the first 2 h in the 3-h ischemic group compared with contralateral control blood flow. No significant increase in postischemic blood flow was noted in the 6-h ischemic group. Postischemic blood flow was significantly decreased by the l-NMMA infusion. Contractile function and viability of the tibialis anterior muscle and contractile function of the gastrocnemius muscle in the l-NMMA group were significantly increased. CONCLUSION Reperfusion blood flow increased time dependently until 3 h of warm ischemia. Hyperemia deteriorated skeletal muscle contractile function, although it was well preserved by l-NMMA infusion to restrict the postischemic hyperemia.
Effect of Retention Interval on the Cue Repetition Effect

Cue repetition can interfere with cued recall (Overton & Adolphson, 1979). In two experiments we showed that in agreement with a contextual change hypothesis this effect is reduced when the interval between the repetition of the cue and the test is lengthened. Contrary to this hypothesis, there was no increase in interference when the interval between studying the pair and the repetition of the cue was increased. The relationship between the cue repetition effect and other interference effects is discussed, and it is argued that cue repetition is potentially a very useful procedure to investigate interference.
The role of signalling molecules on actin glutathionylation and protein carbonylation induced by cadmium in haemocytes of mussel Mytilus galloprovincialis (Lmk)

SUMMARY This study investigated the role of Na+/H+ exchanger (NHE) and signalling molecules, such as cAMP, PKC, PI 3-kinase, and immune defence enzymes, NADPH oxidase and nitric oxide synthase, in the induction of protein glutathionylation and carbonylation in cadmium-treated haemocytes of mussel Mytilus galloprovincialis. Glutathionylation was detected by western blot analysis and showed actin as its main target. A significant increase of both actin glutathionylation and protein carbonylation, were observed in haemocytes exposed to micromolar concentration of cadmium chloride (5 μmol l–1). Cadmium seems to cause actin polymerization that may lead to its increased glutathionylation, probably to protect it from cadmium-induced oxidative stress. It is therefore possible that polymerization of actin plays a signalling role in the induction of both glutathionylation and carbonylation processes. NHE seems to play a regulatory role in the induction of oxidative damage and actin glutathionylation, since its inhibition by 2 μmol l–1 cariporide, significantly diminished cadmium effects in each case. Similarly, attenuation of cadmium effects were observed in cells pre-treated with either 11 μmol l–1 GF-109203X, a potent inhibitor of PKC, 50 nmol l–1 wortmannin, an inhibitor of PI 3-kinase, 0.01 mmol l–1 forskolin, an adenylyl cyclase activator, 10 μmol l–1 DPI, a NADPH oxidase inhibitor, or 10 μmol l–1 L-NAME, a nitric oxide synthase inhibitor, suggesting a possible role of PKC, PI 3-kinase and cAMP, as well as NADPH oxidase and nitric oxide synthase in the enhancement of cadmium effects on both actin glutathionylation and protein carbonylation.
The Secure Relational Database Management System Kernel: Three Years After

A brief look back at the project undertaken by I.P. Sharp Associates for the U.S. Air Force and the Canadian Government on Relational DBMS Kernel design. Since the completion of the project, 3 years ago, several changes have occurred which alter our perception of the project and its results. A quick look at the future in this area is included.
Evaluation of four colourimetric susceptibility tests for the rapid detection of multidrug-resistant Mycobacterium tuberculosis isolates

The purpose of this study is to evaluate four rapid colourimetric methods, including the resazurin microtitre assay (REMA), malachite green decolourisation assay (MGDA), microplate nitrate reductase assay (MNRA) and crystal violet decolourisation assay (CVDA), for the rapid detection of multidrug-resistant (MDR) tuberculosis. Fifty Mycobacterium tuberculosis isolates were used in this study. Eighteen isolates were MDR, two isolates were only resistant to isoniazid (INH) and the remaining isolates were susceptible to both INH and rifampicin (RIF). INH and RIF were tested in 0.25 µg/mL and 0.5 µg/mL, respectively. The agar proportion method was used as a reference method. MNRA and REMA were performed with some modifications. MGDA and CVDA were performed as defined in the literature. The agreements of the MNRA for INH and RIF were 96% and 94%, respectively, while the agreement of the other assays for INH and RIF were 98%. In this study, while the specificities of the REMA, MGDA and CVDA were 100%, the specificity of the MNRA was lower than the others (93.3% for INH and 90.9% for RIF). In addition, while the sensitivity of the MNRA was 100%, the sensitivities of the others were lower than that of the MNRA (from 94.1-95%). The results were reported on the seventh-10th day of the incubation. All methods are reliable, easy to perform, inexpensive and easy to evaluate and do not require special equipment.
Theory of Mind Deficits in Students Who Are Deaf or Hard-of-Hearing

Biber, D. (1995). Dimensions of register variation: A cross-linguistic comparison. Cambridge, UK: Cambridge University Press. Mancilla-Martinez, J., & Lesaux, N. K. (2010). Predictors of reading comprehension for struggling readers: The case of Spanish-speaking language minority learners. Journal of Educational Psychology, 102, 701–711. Mather, N. , Hammill, D. D. , Allen, E. A. , & Roberts, R. (2004). Test of Silent Word Reading Fluency (TOSWRF). Austin, TX: Pro Education. Ochs, E. (1993). Constructing social identity: A language socialization perspective. Research on Language and Social Interaction, 26, 287–306. Proctor, P., Dalton, B. , Uccelli, B. G. , Mo, E. , Snow, C. E. , & Neugebauer, S. (2011). Improving comprehension online: Effects of deep vocabulary instruction with bilingual and monolingual fifth graders. Reading and Writing, 24, 517–544. Ravid, D. , & Tolchinsky, L. (2002). Developing linguistic literacy: A comprehensive model. Journal of Child Language, 29, 419–448. Schleppegrell, M. J. (2012). Academic language in teaching and learning introduction to special issue. Elementary School Journal, 112, 409–418. Snow, C. E. , & Uccelli, P. (2009). The challenge of academic language. In D. R. Olson & N. Torrance (Eds.), The Cambridge handbook of literacy (pp. 112–133). New York, NY: Cambridge University Press.
Dynamic matching range in Exemplar-based Learning Classifier System

This paper proposes the extended version of Exemplar-based Learning Classifier System (ECS) called DMR-ECS which introduces the basis function for the dynamic matching selection in ECS. In comparison with our previous match selection in ECS, the proposed dynamic match selection in DMR-ECS can control an appropriate range of the match selection automatically to extract the exemplars that cover given problem space. Intensive simulation on the cargo layout problem has revealed that DMR-ECS contributes to not only improving the performance but also reducing the number of the exemplars with an appropriate range of the match selection.