Miracle-dz/UniFAR-FTUs huggingface dataset:
Learning strategies in web-supported collaborative project

Web-based learning promotes computer-mediated interaction and student-centred learning in most higher education institutions. To fulfil their academic requirements, students develop appropriate strategies to support learning. Purposes of this study were to: (1) examine the relationship between students study strategies (assessed by Learning and Study Strategies Inventory [LASSI]) with their learning outcomes and online interaction and (2) observe the development of strategies among students in the web-supported collaborative project. Both quantitative and qualitative data were gathered. The results of the study revealed that some LASSI constructs were significant in predicting students’ online learning achievement, including: anxiety, time management, use of support/material and test strategies (p < .05). Students’ interaction significantly correlated with: attitude, motivation, information processing, selecting the main idea, use of support/material and test strategies (p < .05). In addition to LASSI, strategies were identified in the study, including: task analysis, information utilisation, group coordination, self-review and task refinement.
Outcome of Listing for Cardiac Transplantation for Failed Fontan: A Multi-Institutional Study

Background— The Fontan procedure is a successful palliation for children with single-ventricle physiology; however, many will eventually require heart transplantation. The purpose of this study was to determine risk factors for death awaiting transplantation and to examine results after transplantation in Fontan patients. Methods and Results— A retrospective, multi-institutional review was performed of 97 Fontan patients <18 years of age listed at 17 Pediatric Heart Transplant Study centers from 1993 to 2001. Mean age at listing was 9.7 years (0.5 to 17.9 years); 25% were <4 years old; 53% were United Network for Organ Sharing status 1; 18% required ventilator support. Pretransplantation survival was 78% at 6 months and 74% at 12 months and was similar to 243 children with other congenital heart disease (CHD) and 747 children without congenital heart disease (No-CHD), who were also awaiting transplantation. Patients who were younger, status 1, had shorter interval since Fontan, or were on a ventilator were more likely to die while waiting. At 6 months, the probability of receiving a transplant was similar for status 1 and 2 (65% versus 68%); however, the probability of death was higher for status 1 (22% versus 5%). Seventy patients underwent transplantation. Survival was 76% at 1 year, 70% at 3 years, and 68% at 5 years, slightly less than CHD and No-CHD patients. Causes of death included infection (30%), graft failure (17%), rejection (13%), sudden death (13%), and graft coronary artery disease (9%). Protein-losing enteropathy (present in 34 patients) resolved in all who survived >30 days after transplantation. Conclusions— Heart transplantation is an effective therapy for pediatric patients with a failed Fontan. Although early posttransplantation survival is slightly lower than other patients with CHD, long-term results are encouraging, and protein-losing enteropathy can be expected to resolve.
NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A.

Robert E. Chapin, Jane Adams, Kim Boekelheide, L. Earl Gray Jr, Simon W. Hayward, Peter S.J. Lees, Barry S. McIntyre, Kenneth M. Portier, Teresa M. Schnorr, Sherry G. Selevan, John G. Vandenbergh, and Susan R. Woskie Pfizer, Inc., Groton, CT University of Massachusetts, Boston, MA Brown University, Providence, RI U.S. Environmental Protection Agency, Research Triangle Park, NC Vanderbilt University Medical Center, Nashville, TN Johns Hopkins University, Baltimore, MD Schering Plough Research Institute, Summit, NJ American Cancer Society, Atlanta, GA National Institute for Occupational Safety and Health, Cincinnati, OH U.S. Public Health Service (Ret), Silver Spring, MD North Carolina State University, Raleigh, NC University of Massachusetts, Lowell, MA
SNAP‐25 in hippocampal CA1 region is involved in memory consolidation

As a synaptosomal protein, SNAP‐25 plays a role in a number of neuronal functions including axonal growth, dendrite formation, fusion of synaptic vesicles with membrane and the expression of long‐term potentiation (LTP) in the hippocampus. Using a learning/memory behavior screening, we identified SNAP‐25 as one of the differentially expressed genes in the hippocampus upon behavioral training. The inhibition of SNAP‐25 with intracerebroventricular antisense oligonucleotide caused a deficit in long‐ but not short‐term memory for step‐down inhibitory avoidance. Intra‐CA1 infusion of the SNAP‐25 antisense oligonucleotide impaired long‐term contextual fear memory and spatial memory and interfered with the LTP of synaptic transmission in the CA1 region. The inhibitory effect on LTP was not mediated by a pre‐synaptic mechanism because paired pulse facilitation of synaptic transmission was not affected after administration of the antisense oligonucleotide. Together, the results suggest that SNAP‐25 in the CA1 region is involved in memory consolidation.
Design of Compliant Mechanisms Considering Thermal Compensation

1. Abstract Compliant mechanisms attain their mobility from flexibility of their structure instead of depending on hinges, bearings and sliders. Their main advantages are that they can be built using fewer parts, require fewer assembly processes and need no lubrication. These mechanisms have many areas of application: precision mechanic devices, biomedical area and in MicroElectroMechanical Systems (MEMS). As temperature changes may be critical in precision mechanic equipment, since undesired displacements may be generated, one solution is to design a compliant mechanism with thermal compensation. Although this is not easily accomplished by trial and error methods, it can be done by using Topological Optimization Method, which combines Finite Element Method (FEM) with optimization algorithms. The optimization problem is formulated for the design of a compliant mechanism that generates the maximum desired output displacement when a force is applied, minimizing the undesired thermal effect to increase the actuator accuracy. Thus, a logarithm multi-objective function is defined considering the summation of objective functions using weighting coefficients. These functions are: maximization of the output displacement generated by the force, minimization of the displacement generated by thermal effect in the output direction and minimization of the component normal to the output direction. Even though, the combination of many objective functions results in a problem with many local minima, satisfactory solutions could be obtained. A material model based on the traditional SIMP model is adopted and the optimization algorithm is constructed based on sequential linear programming (SLP). A filtering technique is applied to control the mesh dependency and the checkerboard problem. To illustrate the method, two-dimensional compliant mechanisms were designed considering thermal compensation and their performance were compared with compliant mechanisms without thermal compensation to show the improvement. 2.
New Liftable Classes for First-Order Probabilistic Inference

Statistical relational models provide compact encodings of probabilistic dependencies in relational domains, but result in highly intractable graphical models. The goal of lifted inference is to carry out probabilistic inference without needing to reason about each individual separately, by instead treating exchangeable, undistinguished objects as a whole. In this paper, we study the domain recursion inference rule, which, despite its central role in early theoretical results on domain-lifted inference, has later been believed redundant. We show that this rule is more powerful than expected, and in fact significantly extends the range of models for which lifted inference runs in time polynomial in the number of individuals in the domain. This includes an open problem called S4, the symmetric transitivity model, and a first-order logic encoding of the birthday paradox. We further identify new classes S2FO2 and S2RU of domain-liftable theories, which respectively subsume FO2 and recursively unary theories, the largest classes of domain-liftable theories known so far, and show that using domain recursion can achieve exponential speedup even in theories that cannot fully be lifted with the existing set of inference rules.
Key concepts in a framework for analysing visual landscape character

Abstract A transparent and theory-based scheme for analysing visual character is presented. Based on a literature review, nine key visual concepts are identified: stewardship, coherence, disturbance, historicity, visual scale, imageability, complexity, naturalness and ephemera. The nine visual concepts are presented in a framework of four levels of abstraction, described through the concepts' visual dimensions, landscape attributes contributing to the concepts and potential visual indicators suggested for mapping and quantifying the concepts. Each of these concepts focuses on different aspects of the landscape important for visual quality, where visual quality is an holistic experience of them all. The visual concepts presented are used to describe different characteristics of visual landscapes, rather than presenting a normative value for visual quality. It is believed that this framework can be important for landscape assessment and the compilation of landscape character.
A portable interface for runtime energy monitoring

As energy consumption becomes a first class concern for computing systems, there is an increasing need for application-level access to runtime power/energy measurements. To support this need, a growing number of power and energy monitors are being developed, each with their own interfaces. In fact, the approaches are extremely diverse, and porting energy-aware code to new platforms with new hardware can involve significant rewriting effort. To reduce this effort and support portable, application-level energy monitoring, a common interface is needed. In this paper, we propose EnergyMon, a portable application interface that is independent of underlying power/energy data sources. We demonstrate EnergyMon's flexibility with two case studies -- energy-aware profiling and self-adaptive systems, each of which requires monitoring energy across a range of hardware from different manufacturers. We release the EnergyMon interface, implementations, utilities, and Java and Rust bindings and abstractions as open source.
The intonational Structuring of Discourse

We propose a mapping between prosodic phenomena and semantico-pragmatic effects based upon the hypothesis that intonation conveys information about the intentional as well as the attentional structure of discourse. In particular, we discuss how variations in pitch range and choice of accent and tune can help to convey such information as: discourse segmentation and topic structure, appropriate choice of referent, the distinction between 'given' and 'new' information, conceptual contrast or parallelism between mentioned items, and subordination relationships between propositions salient in the discourse. Our goals for this research are practical as well as theoretical. In particular, we are investigating the problem of intonational assignment in synthetic speech.
Quantitative analysis of poliomyelitis-like paralysis in mice induced by a poliovirus replicon.

Poliovirus (PV) infection causes severe paralysis, typically of the legs, by destruction of the motor neurons in the spinal cord. In this study, the relationship between PV replication in the spinal cord, damage in the motor neurons and poliomyelitis-like paralysis was analysed in transgenic mice expressing the human PV receptor (TgPVR21). First, a PV replicon encoding firefly luciferase in place of the capsid genes (PV-Fluc mc) was trans-encapsidated in 293T cells and the trans-encapsidated PV-Fluc mc (TE-PV-Fluc mc) was then inoculated into the spinal cords of TgPVR21 mice. TE-PV-Fluc mc was recovered with a titre of 6.3 x 10(7) infectious units ml(-1), which was comparable to those of PV1 strains. TgPVR21 mice inoculated with TE-PV-Fluc mc showed non-lethal paralysis of the hindlimbs, with severity ranging from a decline in grip strength to complete flaccid paralysis. The replication of TE-PV-Fluc mc in the spinal cord reached peak levels at 10 h post-inoculation (p.i.), followed by the appearance of paralysis at as early as 12 h p.i. , reaching a plateau at 16 h p.i. Histological analysis showed a correlation between the lesion and the severity of the clinical symptoms in most mice. However, severe paralysis could also be observed with an apparently low lesion score, where as few as 5.3 x 10(2) motor neurons (1.4 % of the susceptible cells in the lumbar cord) were infected by TE-PV-Fluc mc. These results indicate that PV replication in a small population of the motor neurons was critical for severe residual poliomyelitis-like paralysis in TgPVR21 mice.
4-DoF Tracking for Robot Fine Manipulation Tasks

This paper presents two visual trackers from the different paradigms of learning and registration based tracking and evaluates their application in image based visual servoing. They can track object motion with four degrees of freedom (DoF) which, as we will show here, is sufficient for many fine manipulation tasks. One of these trackers is a newly developed learning based tracker that relies on learning discriminative correlation filters while the other is a refinement of a recent 8 DoF RANSAC based tracker adapted with a new appearance model for tracking 4 DoF motion. Both trackers are shown to provide superior performance to several state of the art trackers on an existing dataset for manipulation tasks. Further, a new dataset with challenging sequences for fine manipulation tasks captured from robot mounted eye-in-hand (EIH) cameras is also presented. These sequences have a variety of challenges encountered during real tasks including jittery camera movement, motion blur, drastic scale changes and partial occlusions. Quantitative and qualitative results on these sequences are used to show that these two trackers are robust to failures while providing high precision that makes them suitable for such fine manipulation tasks.
Reliability of Opinionaire Technique Studied Intensively by the Retest Method

Resume Un groupe d'etudiants universitaires a subi pour la seconde fois l'Opinionnaire de Lentz pour la mesure du conservatisme et l'Inventaire de la Personnalite de Bernreuter. Vingt pour cent de toutes les reactions des tests ont ete renversees dans la repetition. Quatre-vingts pour cent de celles-ci se balancent et donc n'influent pas sur le resultat final pour le sujet ou pour la partie du test. Les correlations pour les resultats totaux personnels entre la premiere epreuve et la seconde ont ete pour l'opinionnaire de 0,94 et pour l'inventaire de 0,92, 0,91, 0,90, et 0,915 dans ses divers aspects. Comme mesure de l'opinion des parties individuelles des tests pour chaque groupe le second test donne une correlation de 0,943 pour l'opinionnaire. Le changement des reactions aux parties des tests se montre une fonction des personnes qui subissent le test ainsi que celle des parties auxquelles elles reagissent. La variabilite des personnes est mesuree par le resultat du “changement,” lequel montre une const.
Decoding emotional messages: Influence of ethnicity, sex, message type, and channel

In this study, we predicted that sex of sender and receiver, ethnic group of sender, positivity of affect, and communication channel would all influence decoding of emotional messages. Thirty-four male and 47 female Anglo-Australian subjects viewed videotapes of male or female Australian, British, or Italian speakers, who each presented 18 content-ambiguous messages with positive, negative, or neutral affect. Subjects guessed the intended affect in each message. Results of analyses of variance revealed that female encoders were better decoded than male encoders for positive and negative messages on all channels, but female decoders were more accurate than males only in the audiovisual (picture and sound) condition. On all channels, positive messages were decoded least accurately, especially when the speakers were Australian men. In addition, results revealed that although Italian men in the audiovisual condition were decoded worse than other men on neutral and negative messages, in the visual (picture only) condition, Italian men were decoded as well as other men. Italian women were decoded as accurately as other women for positive and neutral messages in both the audiovisual and visual conditions. In the audio (sound only) condition, Italian speakers of both sexes were decoded less accurately than other speakers of their sex. It is suggested that Italian accents were a distractor to decoding and that, on hearing Italian-accented English, Anglo-Australian subjects paid less attention because of more negative attitudes toward male Southern European immigrants. Analysis of errors pointed to the latter explanation, as subjects expected Italian male speakers' affect to be more negative than emotion from other speakers.
"Proximal-type" epithelioid sarcoma, a distinctive aggressive neoplasm showing rhabdoid features. Clinicopathologic, immunohistochemical, and ultrastructural study of a series.

Eighteen examples of an unusual malignant soft-tissue neoplasm, the morphology of which ranged from that of "atypical" epithelioid sarcoma to that of a rhabdoid tumor or undifferentiated carcinoma (with transitional forms) are described. Patients included 11 males and seven females; their median age was 35.5 years with most patients aged 20 to 40 years. Development of a mass was the main presenting symptom. Six tumors developed in the pelvis and perineal region, four in the pubic region and vulva, three in the buttocks, one in the deep soft tissues of the left hip, one on the penis, one in left forearm, one in left axilla, and one on the occiput. Tumor size ranged from 1 to 20 cm (median, 4 cm). On microscopic examination, the tumor cells invaded the subcutaneous or deep soft tissues, had prominent epithelioid or rhabdoid features, had marked cytologic atypia, and grew in a multinodular pattern in half of the cases. Areas of necrosis were often seen. A granuloma-like pattern reminiscent of that observed in classic epithelioid sarcoma was observed in only two cases. Immunohistochemically, positivity for cytokeratin, epithelial membrane antigen, and vimentin was seen in all but one of the cases. Of 16 cases, 10 and eight tumors reacted with desmin and CD34, respectively; five of 15 reacted at least focally with smooth-muscle actin, whereas three of 13 and one of 10 reacted for HMB-45 and carcinoembryonic antigen, respectively. S-100 protein and CD31 yielded negative results. Seven tumors were investigated at the ultrastructural level, four of which showed prominent intracytoplasmic intermediate filament aggregates, often accumulating into paranuclear whorls, which is in keeping with the rhabdoid phenotype. Five tumors showed features of epithelial differentiation (i.e., tonofilament-like structures or desmosomes or both), whereas one tumor displayed features of myofibroblastic differentiation. Differential diagnoses include mainly conventional epithelioid sarcoma, extrarenal malignant rhabdoid tumor, epithelioid malignant peripheral nerve sheath tumor, melanoma, rhabdomyosarcoma, and undifferentiated carcinoma. Follow-up information on 14 patients (range, 4 months to 8 years; median, 19 months) revealed local recurrence in one case and metastatic dissemination in six patients, leading to death in five. In our opinion, the above-described neoplasms represent a usually "proximal-type" of epithelioid sarcoma. In contrast to the conventional, "distal-type" epithelioid sarcoma, the proximal variant is characterized by a predominantly large-cell, epithelioid cytomorphology, marked cytologic atypia, frequent occurrence of rhabdoid features, and lack of a granuloma-like pattern in most cases. It appears to be somewhat more aggressive (or at least metastasizes earlier) than usual epithelioid sarcoma.
Title: Changes in DNA damage, molecular integrity, and copy number for plastid DNA and mitochondrial DNA during maize development

Our objective was to use long PCR to determine the copy number of ptDNA and mtDNA in total DNA extracted from tissue samples. In previous work, the efficiency of amplification of DNA decreased as the target sequence length increased above about 1 kb, so that DNA quantification using long PCR was considered unreliable (Arezi et al. 2003). Here, we used a long-PCR endpoint procedure to amplify organellar DNA fragments of ~11 kb and performed quantification using gel electrophoresis, ethidium bromide (EtBr)-DNA fluorescence, and DNA mass standards. We achieved an efficiency of ~100% and validated the method for assessing orgDNA damage. These ptDNA and mtDNA primers and long-PCR conditions were used:
Transcriptome profiling of ontogeny in the acridid grasshopper Chorthippus biguttulus

Acridid grasshoppers (Orthoptera:Acrididae) are widely used model organisms for developmental, evolutionary, and neurobiological research. Although there has been recent influx of orthopteran transcriptomic resources, many use pooled ontogenetic stages obscuring information about changes in gene expression during development. Here we developed a de novo transcriptome spanning 7 stages in the life cycle of the acridid grasshopper Chorthippus biguttulus. Samples from different stages encompassing embryonic development through adults were used for transcriptomic profiling, revealing patterns of differential gene expression that highlight processes in the different life stages. These patterns were validated with semi-quantitative RT-PCR. Embryonic development showed a strongly differentiated expression pattern compared to all of the other stages and genes upregulated in this stage were involved in signaling, cellular differentiation, and organ development. Our study is one of the first to examine gene expression during post-embryonic development in a hemimetabolous insect and we found that only the fourth and fifth instars had clusters of genes upregulated during these stages. These genes are involved in various processes ranging from synthesis of biogenic amines to chitin binding. These observations indicate that post-embryonic ontogeny is not a continuous process and that some instars are differentiated. Finally, genes upregulated in the imago were generally involved in aging and immunity. Our study highlights the importance of looking at ontogeny as a whole and indicates promising directions for future research in orthopteran development.
Brain structural damage in Friedreich’s ataxia

Objective: Neuropathological descriptions of the brain in Friedreich’s ataxia (FRDA) were obtained before availability of the current molecular genetic tests for this disease. Voxel-based morphometry (VBM) enables an unbiased whole-brain quantitative analysis of differences in gray matter (GM) and white matter (WM) volume. Methods: Using VBM, we assessed the brain structural damage in 22 patients with genetically confirmed FRDA and 25 healthy controls. The results were correlated with the disease duration and the severity of the patients’ clinical deficits—evaluated using the International Cerebellar Ataxia Rating Scale and Inherited Ataxia Clinical Rating Scale. Results: In patients with FRDA, VBM showed a symmetrical volume loss in dorsal medulla, infero-medial portions of the cerebellar hemispheres, the rostral vermis and in the dentate region. No volume loss in cerebral hemispheres was observed. The atrophy of the cerebellum and medulla correlated with the severity of the clinical deficit and disease duration. Conclusions: In patients with FRDA, significant GM and WM loss was observed only in the cerebellum and dorsal medulla. These structural changes correlate with the severity of the clinical deficit and disease duration.