Miracle-dz/UniFAR-FTUs huggingface dataset:
Experimental analysis of flip-flops minimum operating voltage in 28nm FDSOI and the impact of back bias and temperature

In this paper, the minimum operating voltage of master-slave flip-flops made in advanced fully-depleted silicon on insulator (FDSOI) technology, is studied through silicon measurements. A shift register of 1024 master-slave flip-flops has been fabricated in 28nm FDSOI technology in order to study the minimum operating voltage with respect to a wide back bias range allowed by the FDSOI technology. We show that a maximum yield is obtained for an optimum back bias couple (VBP for PMOS, VBN for NMOS) resulting from a tradeoff between speed and currents ratios. Results are given for a chain of 1, 16, 128, and 1024 FFs in series as well as for two different temperatures (30°C and 80°C). The minimum operating voltage of 1024 FFs is 230mV at 30°C for a back biasing of (VBP,VBN) = (-0.5V,0.5V) and 299mV at 80°C with (VBP,VBN) = (0V,0V).
Magnetic Moment of Cu-Modified Ni2MnGa Magnetic Shape Memory Alloys

The magnetization measurements at 5 K were carried out for Ni2Mn1 − xCuxGa (0 ≤ x ≤ 0.40) and Ni2MnGa1 − yCuy (0 ≤ y ≤ 0.25) alloys. All of the magnetization curves are characteristic of ferromagnetism or ferrimagnetism. By using Arrott plot analysis the spontaneous magnetization of all samples was determined from the magnetization curves. The magnetic moment per formula unit, μs, at 5 K was estimated from the spontaneous magnetization. For Ni2Mn1 − xCuxGa (0 ≤ x ≤ 0.40) alloys μs at 5 K decreases linearly with increasing x. On the other hand, the μs at 5 K for Ni2MnGa1 − yCuy (0 ≤ y ≤ 0.25) alloys decreases more steeply with increasing x compared to the μs for Ni2Mn1 − xCuxGa (0 ≤ x ≤ 0.40) alloys. On the basis of the experimental results, the site-occupation configurations of Ni2Mn1 − xCuxGa (0 ≤ x ≤ 0.40) and Ni2MnGa1 − yCuy (0 ≤ y ≤ 0.25) alloys are proposed.
Trends in the use of care among people aged 65–85 with cognitive impairment in the Netherlands

Abstract Observation of long-term trends within countries is needed to increase insight into how policy initiatives are reflected in the use of care over time in addition to individual determinants of care use. In the past decades, Dutch care policies have favoured homecare and reduced the availability of institutional care which extended the care responsibilities of formal and informal care-givers at home. This study investigates the changes in the use of informal and formal homecare, community services and residential care among cognitively impaired older adults over time in the Netherlands. In addition, of special interest here are the associations of the presence of a spouse, other family members or social network with care use, and the interdependency between the use of different types of care. The study employs the Longitudinal Aging Study Amsterdam (LASA) covering the years 1992–2012, analysed with generalised estimating equations. The data consisted of 1,022 observations gathered from 813 respondents aged 65–85. The respondents were cognitively impaired according to the age- and education-standardised Mini-Mental State Examination score. The analyses took into account several individual determinants of care use. The use of informal care and residential care decreased while the use of formal homecare and community services remained the same. Simultaneously, the proportion of those who did not use the studied care types increased. The contribution of partners in informal care decreased. Informal care and formal homecare use increasingly became complementary services. The findings suggest that the decreases in informal care and residential care have not been replaced by other types of care, as reflected in the increased number of persons receiving no care. Care policies should not rely excessively on the availability of informal help and should guarantee adequate formal help, especially for those in high need.
An Admissible Heuristic for SAS+ Planning Obtained from the State Equation

Domain-independent optimal planning has seen important breakthroughs in recent years with the development of tractable and informative admissible heuristics, suitable for planners based on forward state-space search. These heuristics allow planners to optimally solve an important number of benchmark problems, including problems that are quite involved and difficult for the layman. In this paper we present a new admissible heuristic that is obtained from the state equation associated to the Petri-net representation of the planning problem. The new heuristic, that does not fall into one of the four standard classes, can be computed in polynomial time and is competitive with the current state of the art for optimal planning, as empirically demonstrated over a large number of problems, mainly because it often shows an improved quality-to-cost ratio. The new heuristic applies to SAS+ planning tasks with arbitrary non-negative action costs.
DRIVERS' PERCEPTIONS OF HEADLIGHT GLARE FROM ONCOMING AND FOLLOWING VEHICLES

Recently, U.S. drivers have been expressing concern over the discomfort and reduced visibility that they experience from headlight glare from other vehicles. Drivers have focused their concern on the relatively new high intensity discharge lights, high mounted lights, and various auxiliary lights. In order to better understand this glare problem, the National Highway Traffic Safety Administration collected data on drivers' perception of glare from a representative sample of U.S. drivers. The survey was conducted through Omnibus Survey of the Bureau of Transportation Statistics. The present study is based on the information (data) collected on two types of glare: glare from oncoming and following vehicles. The survey data were analyzed to find out how U.S. drivers perceive the two types of glare and if glare perception is associated with respondents' age and gender. Contingency analysis was conducted to establish these associations. The statistics showed that a sizeable number of respondents feel that glare was 'disturbing'. The percent frequency distributions were used to better understand the age and gender profiles of drivers who felt disturbed by the nighttime glare. It was found that the age group 35 to 44 had the highest percentage of night drivers as well as among those who felt glare 'disturbing'. In addition, female respondents of this age group were more of the opinion that the glare from oncoming and following vehicles was 'disturbing' as compared with other age groups of their own gender or even of the opposite gender.
Control architecture in optical burst-switched WDM networks

Optical burst switching (OBS) is a promising solution for building terabit optical routers and realizing IP over WDM. In this paper, we describe the basic concept of OBS and present a general architecture of optical core routers and electronic edge routers in the OBS network. The key design issues related to the OBS are also discussed, namely, burst assembly (burstification), channel scheduling, burst offset-time management, and some dimensioning rules. A nonperiodic time-interval burst assembly mechanism is described. A class of data channel scheduling algorithms with void filling is proposed for optical routers using a fiber delay line buffer. The LAUC-VF (latest available unused channel with void filling) channel scheduling algorithm is studied in detail. Initial results on the burst traffic characteristics and on the performance of optical routers in the OBS network with self-similar traffic as inputs are reported in the paper.
The role of the charge state of PAHs in ultraviolet extinction

Aims. We explore the relation between the charge state of polycyclic aromatic hydrocarbons (PAHs) and the extinction curve morphology. Methods. We fit extinction curves with a dust model including core-mantle spherical particles of mixed chemical composition (silicate core, sp 2 and sp 3 carbonaceous layers), and an additional molecular component. We use exact methods to calculate the extinction due to classical particles and accurate computed absorption spectra of PAHs in different charge states, for the contribution due to the molecular component, along five different lines of sight. Results. A combination of classical dust particles and mixtures of real PAHs satisfactorily matches the observed interstellar extinction curves. Variations of the spectral properties of PAHs in different charge states produce changes consistent with the varying relative strengths of the bump and non-linear far-UV rise.
Regadenoson in Myocardial Perfusion Study - First Institutional Experiences in Bosnia and Herzegovina

Introduction: Myocardial perfusion imaging (MPI) is widely used in the evaluation of known and suspected coronary artery disease (CAD). Imaging of heart in stress and rest enables the comparison of myocardial uptake of radiotracer in proportion to the needs and coronary flow, which is used for detection of perfusion defects. Exercise stress and pharmacologic agents are used for the stressing purpose. Novel pharmacologic stressor regadenoson is A2A selective adenosine agonist, which selectively binds to the adenosine receptors in coronary arteries causing coronary dilatation. Materials and methods: We analyzed 50 myocardial perfusion studies performed with regadenoson as a pharmacologic agent that was injected before Tc99m-sestamibi in stress imaging. Stress and rest sets of images were evaluated for relative uptake of Tc99m-sestamibi in order to detect and characterize perfusion defects. After the injection of regadenoson, hemodynamic parameters and potential side-effects were closely monitored. Side-effects were stratified per severity as mild, moderate and severe. Studies were read by nuclear medicine physicians using quantitative perfusion SPECT software. Additional diagnostic information such as wall motion and wall thickening were provided by gating. Results: Thirty-three patients (66%) experienced one or more side-effects upon the administration of regadenoson, most commonly warmth and chest discomfort. In all patients but one (98%), the symptoms were mild, of short duration and self-limiting. Out of all side-effects registered, 44 (96%) were mild, and 2 (4%) were moderate. Two moderate side-effects developed in one patient with a prior history of asthma, and included shortness of breath and cough. Heart rate changed by 16 +- 31 bpm. Highest increase in blood pressure was 30 mm Hg for systolic, and 10 mm Hg for diastolic. One case of significant decrease in blood pressure was noted from the hypertensive basal values, 50 mm for systolic, and 30 mm Hg for diastolic. ST segment depression of up to 1 mm occurred in 4 cases (8%), and T-wave changes in 3 cases (6%). No conduction abnormalities, significant hypotension, symptomatic bradycardia or cardiac arrest ocurred. Conclusion: Our first institutional experiences proved regadenoson as A2A selective adenosine agonist as a pharmacologic stressor to be safe, tolerable and easily used. Its safety profile enabled the study to be performed in patients with respiratory disease also.
Studies on effect of Copper corrosion passivators on the Paper insulated copper conductor by XRD , SEM and EDX analysis

The paper focuses on corrosion phenomena involving copper, corrosive sulphur and solid insulation of oil-immersed transformers. A study of the available mitigation technique such as passivation to reduce the effects of corrosion phenomena is carried out with the commercially available passivator, Irgamet 39 (Toluiltriazole dialkylamine) (ciba), with concentration of 100 ppm. The paper insulated copper conductors with transformer oil are aged for 1400 hrs at 140° C with and without passivators and tested both paper insulation and copper samples with the X-ray Diffraction (XRD), Scanning Electron Microscope(SEM) and Energy dispersive X-ray Spectroscopy (EDX). The SEM scan after ageing with passivator shows the formation of thin film of passivator on the copper surface. The SEM, XRD and EDX scans after ageing without passivator show the formation of copper sulphide on the copper surface as well as on the
Benefits of an FPGA based SRM controller

This paper proposes that a Field Programmable Gate Array (FPGA) based Switched Reluctance Motor (SRM) controller has greater flexibility and potential performance benefits than a typical Digital Signal Processor (DSP) or Microprocessor based system. The benefits stem from the architecture of an FPGA which allows designers to make a completely customisable controller. The architecture also allows enhanced sampling of the phase current and voltages which allows for higher quality data capture which can improve drive performance. A basic overview of the operation of an FPGA is given to provide context of the system architecture. Comparisons between an FPGA and a DSP based system are made within the context of an SRM controller, which further highlight the potential benefits. Lastly a basic concept design of an FPGA SRM based controller is shown and its enhanced phase current capture design methodology explained.
Krüppel-Like Factor 4 Acts as an Oncogene in Colon Cancer Stem Cell-Enriched Spheroid Cells

Cancer stem cells (CSCs), a rare population in any type of cancers, including colon cancer, are tumorigenic. It has been thought that CSCs are responsible for cancer recurrence, metastasis, and drug resistance. Isolating CSCs in colon cancers is challenging, and thus the molecular mechanism regulating the self-renewing and differentiation of CSCs remains unknown. We cultured DLD-1 cells, one of types of cells derived from colon cancers, in serum-free medium to obtain spheroid cells. These cells possessed the characteristics of CSCs, with the expression of CD133, CD166, Lgr5, and ALDH1, higher capacities of chemo-resistance, migration, invasion, and tumorigenicity in vitro and in vivo than the adherent DLD-1 cells. Krüppel-like factor 4 (KLF4) is essential factor for maintaining self-renewal of adult and embryonic stem cells. It has been used to induce pluripotent stem cells (iPS) from somatic cells. Since KLF4 is expressed in colon cancer cells, we investigated its role in spheroid cells isolated from DLD-1 cells and found that KLF4 was overexpressed only in spheroid cells and reducing the expression of KLF4 by short-hairpin RNA significantly decreased the capacities of these cells to resist the chemicals, migrate, invade, and generate tumors in vitro and in vivo. The spheroid cells with reduced KLF4 expression also had decreased expression of CSCs markers and mesenchymal markers. Taken together, culturing DLD-1 cells in serum-free medium enriches CSCs and the expression of KLF4 is essential for the characteristics of CSCs in DLD-1; thus KLF4 can be a potential therapeutic target for treating colon cancer.
EONA: Experience-Oriented Network Architecture

There is a growing recognition among researchers, industry practitioners, and service providers of the need to optimize user-perceived application experience. Network infrastructure owners (i.e., ISPs) have traditionally been left out of this equation, leading to repeated tussles between content providers and ISPs. In parallel, application providers have to deploy complex workarounds that reverse engineer the network's impact on application-level metrics. In this work, we make the case for EONA, a new network paradigm where application providers and network providers can collaborate meaningfully to improve application experience. We observe a confluence of technology trends that are enablers for EONA: the ability to collect large volumes of client-side application measurements, the emergence of novel "big data" platforms for real-time analytics, and new control plane capabilities for ISPs (e.g., SDN, IXPs, NFV). We highlight the challenges and opportunities in designing suitable EONA interfaces between infrastructure and application providers and EONA-enhanced control loops that leverage these interfaces to optimize user experience.
Creating 3D specific systems: Architecture, design and CAD

3D stacking and integration can provide system advantages. Following a brief technology review, this abstract explores application drivers, design and CAD for 3D ICs. The main application area explored in detail is that of logic on memory. This application is explored in a specific DSP example. Finally critical areas that need better solutions are explored. These include design planning, test management, and thermal management.
Triggered massive-star formation on the borders of Galactic HII regions. III. Star formation at the periphery of Sh2-219

Context. Massive-star formation triggered by the expansion of HII regions. Aims. To understand if sequential star formation is taking place at the periphery of the HII region Sh2-219. Methods. We present 12CO(2-1) line observations of this region, obtained at the IRAM 30-m telescope (Pico Veleta, Spain). Results. In the optical, Sh2-219 is spherically symmetric around its exciting star; furthermore it is surrounded along three quarters of its periphery by a ring of atomic hydrogen. This spherical symmetry breaks down at infrared and millimetre wavelengths. A molecular cloud of about 2000\msol lies at the southwestern border of Sh2-219, in the HI gap. Two molecular condensations, elongated along the ionization front, probably result from the interaction between the expanding HII region and the molecular cloud. In this region of interaction there lies a cluster containing many highly reddened stars, as well as a massive star exciting an ultracompact HII region. More surprisingly, the brightest parts of the molecular cloud form a `chimney', perpendicular to the ionization front. This chimney is closed at its south-west extremity by H-alpha walls, thus forming a cavity. The whole structure is 7.5 pc long. A luminous H-alpha emission-line star, lying at one end of the chimney near the ionization front, may be responsible for this structure. Confrontation of the observations with models of HII region evolution shows that Sh2-219 is probably 10^5 yr old. The age and origin of the near-IR cluster observed on the border of Sh2-219 remain unknown.
La Realidad Virtual como herramienta para el tratamiento del trastorno obsesivo compulsivo

Obsessive Compulsive Disorder (OCD) is experienced by 2.6% of the population in Mexico, which severely affects the quality of life of these people. The WHO classifies OCD as the tenth leading cause of disability in the world. There are various treatments for this disorder, including exposure treatment prevention of response and cognitive treatment. Some treatments can be perceived as aversive and between 25% and 35% of patients stop the treatment because of the anxiety experienced in the exposure. The Virtual Teaching and Ciberpsychology Laboratory of UNAM, presents a treatment based on virtual reality, to expose in a controlled manner to patients with OCD, which consists in applying the techniques of exposure and response prevention, giving the facility to therapist to gradually introduce visual and auditory stimuli as well as the possibility of replicating the events as many times as needed during a session. Thus, the patient can be expose to a virtual environment that seems safe and allows making the exposure gradual and
Fungal infections in recipients of hematopoietic stem cell transplants: results of the SEIFEM B-2004 study--Sorveglianza Epidemiologica Infezioni Fungine Nelle Emopatie Maligne.

BACKGROUND The purpose of our study was to evaluate the incidence and outcome of invasive fungal infection (IFI) among patients who underwent autologous or allogeneic hematopoietic stem cell transplantation (HSCT) at 11 Italian transplantation centers. METHODS This cohort-retrospective study, conducted during 1999-2003, involved HSCT patients admitted to 11 tertiary care centers or university hospitals in Italy, who developed IFIs (proven or probable). RESULTS Among 3228 patients who underwent HSCT (1249 allogeneic HSCT recipients and 1979 autologous HSCT recipients), IFI occurred in 121 patients (overall incidence, 3.7%). Ninety-one episodes (2.8% of all patients) were due to molds, and 30 (0.9%) were due to yeasts. Ninety-eight episodes (7.8%) occurred among the 1249 allogeneic HSCT recipients, and 23 (1.2%) occurred among the 1979 autologous HSCT recipients. The most frequent etiological agents were Aspergillus species (86 episodes) and Candida species (30 episodes). The overall mortality rate was 5.7% among allogeneic HSCT recipients and 0.4% among autologous HSCT recipients, whereas the attributable mortality rate registered in our population was 65.3% (72.4% for allogeneic HSCT recipients and 34.7% for autologous HSCT recipients). Etiology influenced the patients' outcomes: the attributable mortality rate for aspergillosis was 72.1% (77.2% and 14.3% for allogeneic and autologous HSCT recipients, respectively), and the rate for Candida IFI was 50% (57.1% and 43.8% for allogeneic and autologous HSCT recipients, respectively). CONCLUSIONS IFI represents a common complication for allogeneic HSCT recipients. Aspergillus species is the most frequently detected agent in these patients, and aspergillosis is characterized by a high mortality rate. Conversely, autologous HSCT recipients rarely develop aspergillosis, and the attributable mortality rate is markedly lower. Candidemia was observed less often than aspergillosis among both allogeneic and autologous HSCT recipients; furthermore, there was no difference in either the incidence of or the attributable mortality rate for candidemia among recipients of the 2 transplant types.
Predicting Protein Secondary Structure Based on Compound Pyramid Model

Biological processes have produced the ultimate intelligent system, and now we are trying to understand biology by building intelligent systems. Protein Secondary structure prediction is essential for the tertiary structure modeling, and it is the one of the major challenge of bioinformatics. In this paper, we proposed a new type of intelligent system to predict the protein secondary structure, and it contain a Compound Pyramid Model (CPM) which is gradually enhanced, multi-layered. This model is composed of four independent coordination's layers by intelligent interfaces, synthesizes several methods. The model penetrates the whole domain knowledge, and the effective attributes are chosen by Causal Cellular Automata, and the high pure structure database is constructed for training. An optimized accuracy (Q3) for the RS126 and CB513 dataset of 83.99% and 85.58%, respectively, could be obtained. And the CASP8's sequences, the results are found to be superior to those produced by other methods, such as PSIPRED,SSPRO,SAM-T02,PHD Expert, PROF, JPRED, and so on. The result shows that our method has strong generalization ability.