Miracle-dz/UniFAR-FTUs huggingface dataset:
A two-stage stochastic model for cloud computing simulation of resource efficiency cost analysis

Cloud computing has changed the traditional way of the Internet resource provision into the pay-per-use, but how to evaluate the performance and the Quality of service(QoS) by using simulation tool is a complex problem given the limits of physical resource. Considering these issues, we design a two-stage stochastic model based on queueing network theory for the cloud computing simulation. It composes the complete structure of Infrastructure as a Service and can be used to analyze the performance and the resource utilization rate under different running environments and resource specifications. To demonstrate the validity of the model, an example of the minimum resource for QoS guaranteeing search (MROGS) algorithm which can search the suitable threshold of resource size is given. The simulation results indicate that the model can accurately present the real performance of cloud computing platform, and the MROGS algorithm can find a suitable resource threshold to achieve higher resource utilization rate and assure the QoS simultaneously.
Multicolor Organic Light-Emitting Diodes Processed by Hybrid Inkjet Printing**

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Characterization of oil and water accommodated fractions used to conduct aquatic toxicity testing in support of the Deepwater Horizon oil spill natural resource damage assessment

The Deepwater Horizon blowout resulted in the release of millions of barrels of crude oil. As part of the Trustees’ Natural Resource Damage Assessment, a testing program was implemented to evaluate the toxicity of Deepwater Horizon oil and oil/dispersant mixtures to aquatic organisms from the Gulf of Mexico. Because of the variety of exposures that likely occurred, the program included 4 Deepwater Horizon oils, which encompassed a range of weathering states, and 3 different oil‐in‐water mixing methods, for a total of 12 unique water accommodated fractions (WAFs). The present study reports on the chemical characteristics of these 4 Deepwater Horizon oils and 12 WAFs. In addition, to better understand exposure chemistry, an examination was conducted of the effects of WAF preparation parameters—including mixing energy, starting oil composition, and oil‐to‐water mixing ratios—on the chemical profiles and final concentrations of these 12 WAFs. The results showed that the more weathered the starting oil, the lower the concentrations of the oil constituents in the WAF, with a shift in composition to the less soluble compounds. In addition, higher mixing energies increased the presence of insoluble oil constituents. Finally, at low to mid oil‐to‐water mixing ratios, the concentration and composition of the WAFs changed with changing mixing ratios; this change was not observed at higher mixing ratios (i.e., >1 g oil/L). Ultimately, the present study provides a basic characterization of the oils and WAFs used in the testing program, which helps to support interpretation of the more than 500 Deepwater Horizon Natural Resource Damage Assessment toxicity testing results and to enable a comparison of these results with different tests and with the field. Environ Toxicol Chem 2017;36:1450–1459. © 2016 SETAC
Quercetin Prevents Diastolic Dysfunction Induced by a High-Cholesterol Diet: Role of Oxidative Stress and Bioenergetics in Hyperglycemic Rats

Alterations in cardiac energy metabolism play a key role in the pathogenesis of diabetic cardiomyopathy. Hypercholesterolemia associated with bioenergetic impairment and oxidative stress has not been well characterized in the cardiac function under glycemic control deficiency conditions. This work aimed to determine the cardioprotective effects of quercetin (QUE) against the damage induced by a high-cholesterol (HC) diet in hyperglycemic rats, addressing intracellular antioxidant mechanisms and bioenergetics. Quercetin reduced HC-induced alterations in the lipid profile and glycemia in rats. In addition, QUE attenuated cardiac diastolic dysfunction (increased E:A ratio), prevented cardiac cholesterol accumulation, and reduced the increase in HC-induced myocyte density. Moreover, QUE reduced HC-induced oxidative stress by preventing the decrease in GSH/GSSG ratio, Nrf2 nuclear translocation, HO-1 expression, and antioxidant enzymatic activity. Quercetin also counteracted HC-induced bioenergetic impairment, preventing a reduction in ATP levels and alterations in PGC-1α, UCP2, and PPARγ expression. In conclusion, the mechanisms that support the cardioprotective effect of QUE in rats with HC might be mediated by the upregulation of antioxidant mechanisms and improved bioenergetics on the heart. Targeting bioenergetics with QUE can be used as a pharmacological approach to modulate structural and functional changes of the heart under hypercholesterolemic and hyperglycemic conditions.
Walking recognition method for physical activity analysis system of child based on wearable accelerometer

Activities of daily living (ADL) recognition based on accelerometer is an increasingly important study, which is often treated as a multi-class classification problem and can be put into use widely in life. However, it treats all activities equally so that it can not obtain high accuracy in some specific activities, but also lacks specific research that combines application scenarios. This paper presents Hierarchical AdaBoost: a walking recognition method for physical activity analysis system of child based on wearable accelerometer. In order to improve the accuracy of classification, we improve AdaBoost classifier into two-layer classifier. The experimental results show that Hierarchical AdaBoost has higher performance comparing with one-class classification such as SVM, AutoEncoder, K-means and KNN for walking recognition.
Association between sperm mitochondrial ND2 gene variants and total fertilization failure

ABSTRACT The objective of this study was to explore the association of sperm mitochondrial ND2 (MT-ND2) gene variants with total fertilization failure (TFF). A retrospective comparative study of 246 cases of fresh in vitro fertilization (IVF) cycles or half-intracytoplasmic sperm injection cycles in the Han Chinese population was performed from July 2011 to May 2017. A total of 59 cases undergoing TFF, and 187 control cases with normal fertilization (fertilization rates >50%) were included. The sperm mitochondrial genovariation was determined using nested sequencing. A total of 32 homoplasmic variants and 47 heteroplasmic variants of MT-ND2 gene were observed in this study. There were no significant differences in the frequencies of the 32 homoplasmic variants of MT-ND2 gene between the TFF and control groups. A total of 53 pair-wise comparisons were performed, and the general characteristics of the IVF failure and control subjects were adjusted in logistic models. Data suggested that there were no significant differences in the frequencies of point 4914, 5320, and 5426 heteroplasmic variants of MT-ND2 gene between the TFF and control groups. In addition, no significant difference was observed in the frequency of mtDNA haplogroup D or haplogroup G between the IVF failure group and the normal fertilization group. This study suggests that the MT-ND2 gene variants might not be associated with TFF. Abbreviations: ATP: adenosine triphosphate; dNTP: deoxy-ribonucleoside triphosphate; FADH2: flavin adenine dinucleotide; FDR: false discovery rate; FSH: follicle-stimulating hormone; IVF: in vitro fertilization; LH: luteinizing hormone; MTATP6: mitochondrially encoded ATP synthase 6; MTCYB: mitochondrially encoded cytochrome b; mtDNA: mitochondrial DNA; MT-ND2: mitochondrial ND2; NADH: nicotinamide adenine dinucleotide; ND2: NADH dehydrogenase subunit 2; OXPHOS: oxidative phosphorylation; PCR: single nucleotide polymorphisms; SNPs: single nucleotide polymorphisms; TFF: total fertilization failure
An autonomous elevator button recognition system based on convolutional neural networks

The ability to operate an elevator is significant for service robots to move freely inside a building and the elevator button recognition is placed as one of the most critical functions of this process. However, the variety of button styles, the different light conditions and the blurred images caused by the camera motion make this task difficult. To tackle this obstacle to achieve the robust real-time performance, a button recognition system is proposed based on the convolutional neural networks. In consideration of the diverse button shapes, a contour extraction algorithm and the noise filtering are specifically designed to avoid the exhaustive search and reduce the consumed time. Then the fine-tuned CNN model is trained on our established elevator button dataset to achieve a more reliable recognition performance comparing to the template matching methods. Besides, the arrangement pattern of buttons is utilized to deduce the missing buttons and correct mistakes. To verify our algorithm, we run our algorithm on a dataset of 5 distinct elevators. Our algorithm succeeds in localizing and recognizing 98% of the buttons in known elevators and 87.6% in unknown elevators and has an average speed of 3 frames per second.
Comparative analysis of cultural isolation and PCR based assay for detection of Campylobacter jejuni and Campylobacter coli in foods of animal origin

The present study was designed to determine the occurrence of C. jejuni and C. coli in chicken meat, chicken offal, chevon and milk samples from Bareilly, Uttar Pradesh (India) to elucidate the role of these products in transmission of Campylobacter to humans. The samples were examined using both cultural as well as polymerase chain reaction based detection method. Out of 280 samples examined, 29 (10.36%) samples were found positive by cultural method, where as 68 (24.29%) samples showed presence of Campylobacter species by polymerase chain reaction. All the samples depicted positive by culture were also found positive by PCR. The highest occurrence rate was observed in chicken meat (46%), followed by chicken offal (20%), chevon (18%) and milk (3.75%). The results depicted the superior efficacy of PCR for rapid screening of samples owing to its high rapidity, specificity and automation potential. The study suggested the potential of transmission of Campylobacter species to humans due to the consumption of raw or contaminated meat or milk.
Partially squeezing the resources of the web of data towards applications

The Web of Data (WOD) contains a large amount of formalized and interconnected data, offering a valuable help for experimental tasks requiring an accurate data representation. However, the practical application of such data is often limited by the complexity when it comes to extracting the necessary information, mainly because of the lack of a proper structure and organization in the WOD-resources. The (re)organization of the knowledge contained in these resources might facilitate the identification of the necessary information and, consequently, limit the problems arising in their practical application. In this context, this paper proposes the application of Formal Concept Analysis (FCA) to create a concept-based abstraction that better organizes the knowledge contained in the WOD-resources. In order to test, to what extent this enhanced organization is able to improve the data representation process, the obtained FCA models will be tested in a practical application to represent a set of Twitter contents in a specific task: the Topic Detection task at Replab 2013. The results demonstrate that the better data representation obtained through FCA improves the operation of the topic detection process, outperforming state-of-the-art results.
A Social Identity Approach to Understanding Responses to Child Sexual Abuse Allegations

Two studies investigated the role of group allegiances in contributing to the failure of institutions to appropriately respond to allegations of child sexual abuse. In Study 1, 601 participants read a news article detailing an allegation of child sexual abuse against a Catholic Priest. Catholics were more protective of the accused–and more skeptical of the accuser—than other participants, an effect that was particularly pronounced among strongly identified Catholics. In Study 2 (N = 404), the tendency for Catholics to be more protective of the accused and more skeptical of the accuser than non-Catholics was replicated. Moreover, these effects held independently of the objective likelihood that the accused was guilty. Overall, the data show that group loyalties provide a psychological motivation to disbelieve child abuse allegations. Furthermore, the people for whom this motivation is strongest are also the people who are most likely to be responsible for receiving and investigating allegations: highly identified ingroup members. The findings highlight the psychological mechanisms that may limit the ability of senior Church figures to conduct impartial investigations into allegations of child abuse within the Church.
Performance of ZF and RZF in massive MIMO with channel aging

Outdated channel or channel aging severely affects the performance of LS-MIMO systems. In this paper we investigate LS-MIMO systems with the effects of outdated channel. We derive new minimum-mean-square error (MMSE) estimate for LS-MIMO system with outdated channel. Then we investigate the effects of channel aging in uplink (UL) by deriving a complete system model. We show that regularized zero-forcing (RZF) outperforms zero-forcing (ZF) and can be the better choice in massive MIMO systems.
Sympathetic neural reactivity to mental stress differs in black and non-Hispanic white adults.

Black adults have a higher risk of hypertension compared with non-Hispanic white (NHW) adults, but physiological mechanisms underlying this predisposition remain unclear. This study compared muscle sympathetic nerve activity (MSNA) responses to mental stress in a group of young black and NHW participants. We hypothesized that the sympathoexcitation associated with mental stress would be greater in black adults compared with NHW participants. Thirty-five male adults (19 black, 23 ± 1 yr; 16 NHW, 22 ± 1 yr) were examined during 5-min supine baseline and 5 min of mental stress (via mental arithmetic). Baseline mean arterial pressure (80 ± 2 vs. 82 ± 1 mmHg), heart rate (61 ± 4 vs. 61 ± 2 beats/min), MSNA (13 ± 1 vs. 15 ± 2 bursts/min), and sympathetic baroreflex sensitivity (-1.1 ± 0.4 vs. -1.5 ± 0.3 bursts·100 heart beats-1·mmHg-1) were not significantly different between NHW and black adults ( P > 0.05), respectively. MSNA reactivity to mental stress was significantly higher in NHW compared with black adults (time × race, P = 0.006), with a particularly divergent responsiveness during the first minute of mental stress in NHW (Δ4 ± 1 burst/min) and black (Δ-2 ± 2 burst/min; P = 0.022) men. Blood pressure and heart rate reactivity to mental stress were similar between groups. In summary, black participants demonstrated a lower MSNA responsiveness to mental stress compared with NHW adults. These findings suggest that, despite a higher prevalence of hypertension, black subjects do not appear to have higher neural and cardiovascular responsiveness to mental stress compared with NHW. NEW & NOTEWORTHY Black men have a blunted muscle sympathetic nerve activity response to mental stress compared with non-Hispanic white (NHW) men, especially at the onset of mental stress when muscle sympathetic nerve activity decreased in blacks and increased in NHW men. Thus, despite a high prevalence of hypertension in blacks, normotensive NHW men display a greater peripheral sympathetic neural reactivity to mental stress than black men.
Maximum-minimum eigenvalue detection-based method to mitigate the effect of the PUEA in cognitive radio networks

In cognitive radio (CR) networks, secure spectrum sensing is a very important issue. The primary user emulation attack (PUEA), a special attack of the spectrum sensing technology in CR Networks, reduces the spectrum utilization obviously. And our analysis reveals the undetected PUEA can prevent unlicensed users from accessing the space licensed spectrum effectively. In this paper, we propose the maximum-minimum eigenvalue detection-based method to mitigate the effect of the undetected PUEA in CR networks with correlated signals and spatially-correlated shadow fading. In our proposed method, the spatial correlation characteristic is used to select users attending the cooperation of the spectrum sensing. Simulation results show that our proposed method can effectively mitigate the effect of the PUEA.
Limiting dilution comparison of the repertoires of high and low responder MHC-restricted T cells

To approach the mechanism that determines Ir gene-controlled high or low responsiveness to whole proteins, such as sperm whale myoglobin (SWMb), we compared the repertoires of high and low responder haplotype- restricted T cells for different myoglobin epitopes by limiting dilution frequency analysis. Poisson analysis was performed using long- term limiting dilution cell lines of (B10.BR [low] X B10.D2[high])F1 T cells maintained on high or low responder APCs. The cell lines were tested with SWMb peptides and fragments for T cell repertoire fine specificities and Ia restrictions. The frequency of SWMb-specific F1 T cells responsive on B10.BR (H-2k) APCs was 2.5-3.6-fold lower than on B10.D2 (H-2d) APCs. Strikingly, all of the H-2k-restricted T cells used I-Ek as a restriction element, whereas both I-Ad- and I-Ed-restricted T cells were found among the H-2d-restricted lines. The I-Ad-restricted T cells were dominant, and the majority was specific for the synthetic peptide 102-118. T cells specific for peptide 132-146, dominant in association with I-Ed, were less frequent. However, no detectable H-2k- restricted T cells were specific for either of these peptides, but instead they were specific for fragment 1-55 or peptide 59-80. Fragment 1-55 also stimulated a similar number of H-2d-restricted T cells. Therefore, the low response of F1 T cells on H-2k-presenting cells may be due to the failure to see myoglobin plus I-Ak, in particular the immunodominant site around Glu 109, in contrast to the dominant response of high responder mice (both H-2d and H-2s) focused on the I-A molecule and the site around residue Glu 109. The I-E- low responder B10 strain also failed to respond to peptide 102-118, supporting the idea that the low responder status results from a limited repertoire lacking response to 102-118 plus I-A. In those strains that respond to the immunodominant site 102-118, the frequency of T cells in the repertoire specific for this site was always considerably greater than that for other sites. These results suggest that there is an important difference between immunodominant epitopes and minor epitopes and that Ir gene-controlled low responsiveness to a natural whole protein may be due primarily to the failure to respond to a single immunodominant site, even though a number of other epitopes can be recognized.
TP53 mutations and number of alterations correlate with maximum standardized uptake value (SUVmax) determined by positron emission tomography/computed tomography (PET/CT) [18F] fluorodeoxyglucose (18F-FDG PET)

Background Our study explored the relationship between the molecular changes in cancer and the maximum standardized uptake value (SUVmax) determined by positron emission tomography/computed tomography (PET/CT) with [18F] fluorodeoxyglucose (18F-FDG). Results A higher SUVmax correlated with TP53 alterations, but not with histologic diagnosis or other gene/pathway mutations or copy number alterations. In data from breast, lung and colon cancer, patients with the highest SUVmax show more genomic anomalies compared to those with the lowest SUVmax (P < 0.005). Conclusions A higher SUVmax on 18F-FDG PET/CT is associated with TP53 tumor suppressor gene anomalies and the presence of more genomic anomalies. Since TP53 alterations and high SUVmax both correlate with a poor prognosis, the underlying mechanism/implications of this association merit further study. Methods Overall, 176 patients with diverse cancers had a tumor biopsy within 6 months after a PET/CT image for SUVmax measurement. The biopsy was interrogated by next generation sequencing (182 to 315 genes). TP53, EGFR, ALK, MYC, MET and FGF/FGFR genes and DNA repair, PI3K/Akt/mTOR (PAM), MEK, CYCLIN, and WNT pathway genes were analyzed.
A New Dimension of Breast Cancer Epigenetics - Applications of Variational Autoencoders with DNA Methylation

In the era of precision medicine and cancer genomics, data are being generated so quickly that it is difficult to fully appreciate the extent of what is discoverable. DNA methylation, a chemical modification to DNA, has been shown to be a significant factor in many cancers and is a candidate data source with ample features for model traing. However, the black-box nature of non-linear models, such as those in deep learning, and a lack of accurately labeled ground truth data have limited the same rapid adoption in this space that other methods have experienced. In this article, we discuss the applications of unsupervised learning through the use of variational autoencoders using DNA methylation data and motivate further work with initial results using breast cancer data provided by The Cancer Genome Atlas. We show that a logistic regression classifier trained on the learned latent methylome accurately classifies disease subtype.
Influence of ion irradiation on the resistive switching parameters of SiOx-based thin-film structures

For the memristive Au/SiOx/TiN/Ti structures produced by magnetron sputtering and demonstrating reproducible bipolar resistive switching, the dependence of resistive states on the dose of irradiation with H+ and Ne+ ions with energy of 150 keV has been established. It is shown that, under proton irradiation, the resistive switching is not deteriorated up to the dose of 1.1016 cm-2, and, in the case of Ne+ irradiation – up to the dose of 3.31015 cm-2 (equivalent by the ionization losses). As the Ne+ ions produce three orders of magnitude more elastic collisions than protons (for the same dose), the obtained results allow to predict the high radiation tolerance of the memristive structures to both ionization and displacement damage.