Miracle-dz/UniFAR-FTUs huggingface dataset:
Living ink: implementation of a prototype sketching language for real time authoring of animated line drawings

Sketching with pen on paper is often used as a way of augmenting spoken descriptions: to help explain how some mechanical device works; to show the flow of information in an organisation, to show the action in a story, and so on. Sketches serve as a focus for the attention of viewers and help make abstract concepts more concrete. But images on paper don't move. Where the time and resources are available, as in preparing a lecture in advance, or producing a television program, authors recognize that moving images are often superior at conveying concepts and holding people's attention. An electronic display is capable of generating moving images in real time. We argue that such a display need not be used just to mimic pen and paper. After all paper is cheap, plentiful, has a wide viewing angle, and doesn't have batteries to run flat. Our 'Living Ink' system is a prototype implementation of a user interface for generating animated line drawings (animated sketches). Our goal was to provide a user interface which can be used in real-time, making interesting animations while an audience watches. This paper describes progress to date towards that objective and discusses proposals for further development.
Caseous calcification of the mitral annulus: computed tomography features

Nevertheless, because for-eign bodies of vegetable origin do not produce hyperintense im-ages, the diagnosis is not usually obtained by CT. Upper gas-trointestinal endoscopy is a useful tool in the study of gastric le-sions and allows the collection of material for histopathologicalevaluation. However, endoscopic biopsies are usually small andsuperficial, which can make it difficult to confirm the diagnosis ofgranuloma pulse
CREMOFAC - a database of chromatin remodeling factors

MOTIVATION Chromatin-remodeling is an important event in the eukaryotic nucleus rendering nucleosomal DNA accessible for various transaction processes. Remodeling Factors facilitate the dynamic nature of chromatin through participation of the collective action of (i) ATP and (ii) Non-ATP dependent factors. Considering the importance of these factors in eukaryotes, we have developed, CREMOFAC, a dedicated and frequently updated web-database for chromatin-remodeling factors. RESULTS The database harbors factors from 49 different organisms reported in literature and facilitates a comprehensive search for them. In addition, it also provides in-depth information for the factors reported in the three widely studied mammals namely, human, mouse and rat. Further, information on literature, pathways and phylogenetic relationships has also been covered. The development of CREMOFAC as a central repository for chromatin-remodeling factors and the absence of such a pre-existing database heighten its utility thus making its presence indispensable. AVAILABILITY http://www.jncasr. ac.in/cremofac/
Draft Genome Sequence of Plasmodium gonderi, a Malaria Parasite of African Old World Monkeys

ABSTRACT Plasmodium gonderi is a primate parasite whose natural host is the African Old World monkeys. Here, we report the draft genome sequence for P. gonderi. The data are useful not only for understanding the evolution of malaria but also for allowing the comparative genomics of malaria parasites.
Mechanisms of the Beneficial Actions of Ischemic Preconditioning on Subcellular Remodeling in Ischemic-Reperfused Heart

Cardiac function is compromised by oxidative stress which occurs upon exposing the heart to ischemia reperfusion (I/R) for a prolonged period. The reactive oxygen species (ROS) that are generated during I/R incur extensive damage to the myocardium and result in subcellular organelle remodeling. The cardiac nucleus, glycocalyx, myofilaments, sarcoplasmic reticulum, sarcolemma, and mitochondria are affected by ROS during I/R injury. On the other hand, brief periods of ischemia followed by reperfusion, or ischemic preconditioning (IPC), have been shown to be cardioprotective against oxidative stress by attenuating the cellular damage and alterations of subcellular organelles caused by subsequent I/R injury. Endogenous defense mechanisms, such as antioxidant enzymes and heat shock proteins, are activated by IPC and thus prevent damage caused by oxidative stress. Although these cardioprotective effects of IPC against I/R injury are considered to be a consequence of changes in the redox state of cardiomyocytes, IPC is considered to promote the production of NO which may protect subcellular organelles from the deleterious actions of oxidative stress. The article is intended to focus on the I/R-induced oxidative damage to subcellular organelles and to highlight the cardioprotective effects of IPC. In addition, the actions of various endogenous cardioprotective interventions are discussed to illustrate that changes in the redox state due to IPC are cardioprotective against I/R injury to the heart.
Anal intraepithelial neoplasia in HIV positive people

Objective: To review the current literature on HIV associated anal intraepithelial neoplasia (AIN). Methods: A comprehensive Medline/Pubmed search was performed for the years 1980–2001 (January) for articles pertaining to HIV associated anal intraepithelial neoplasia. From the MeSH terms “anal intraepithelial neoplasia” and “anal cancer” the following subheadings were used: HIV, homosexual men, HPV, Epidemiology, Etiology, Mortality, Diagnosis, Screening, Drug Therapy, Surgical Therapy, Radio Therapy, Risk factors, ASIL. The search was limited to “human” for all searches. In the absence of enough “randomised controlled trials” the search was extended to clinical trials, reviews, and case reports. One analysis on cost effectiveness and two abstracts presented at 12th World AIDS Conference and 6th Conference on Retrovirus and Opportunistic Infections were included. The 44 publications referred to originate from the United Kingdom (9), the United States (26), and Denmark (5), with one each from Switzerland, Germany, Australia, and France. The Cochrane Database of systematic reviews yielded 11 complete reviews for “anal cancer” and none for “anal intraepithelial neoplasia. ” The textbook of AIDS-related cancers and their treatment was consulted. We also included our personal experience from the treatment of patients at the Chelsea and Westminster Hospital, one of the largest centres for the management of HIV disease in Europe. Conclusion: Routine anal cytological screening followed by appropriate management of AIN is an important issue for HIV infected patients. The natural history of AIN has not been fully established and this prevents clinicians from defining clear management protocols. There is early evidence that the benefits of highly active antiretroviral therapy (HAART) in terms of restoring immune function and reducing opportunistic infections and some neoplasms may not extend to regression of AIN. Under these circumstances it might be predicted that AIN and subsequent progression to invasive anal cancer would rise as HAART prolongs the lives of seropositive people. However, routine anal cytological screening will surely have to await an effective proved intervention for AIN and this would seem to be a pressing clinical goal. Sex Transm Inf (Sex Transm Inf 2001;77:327–331)
p53 family update: p73 and p63 develop their own identities.

Introduction p53 continues to be one of the most intensively studied genes in cancer biology. p53 was initially identified . 20 years ago as a binding partner for the SV40 T oncoprotein. Further studies revealed that p53 is a tumor suppressor gene that is mutated or inactivated in . 50% of human cancers. Furthermore, germ-line p53 mutations cause hereditary cancer in both mice and humans. Molecular and biochemical assays revealed that the p53 protein is a sequence-specific DNA-binding transcription factor. p53 plays a central role in cellular responses to aberrant growth signals and certain cytotoxic stresses, such as DNA damage, by enhancing the transcription of genes that regulate a variety of cellular processes including cell cycle progression, apoptosis, genetic stability, and angiogenesis (1). Interpreting the enormous quantity of p53 data, corresponding to almost 20,000 publications on the National Library of Medicine website, has become more complicated by the recent identification of two p53 paralogues, p63 and p73. Until recently, p53 was thought to be a unique gene with no genetic paralogues. Daniel Caput identified the first p53related gene, p73, ;4 years ago (2). Several groups then independently identified the third member of the family, p63 (also known as p51, KET, p40, p73L, p53CP, and NBP; Refs. 3–9). Additional “p53-like” genes are unlikely to be identified because searches of the recently published human genome sequence revealed no additional p53 family members (10, 11). The structures of the p63 and p73 genes are more similar to one another than to p53. However, p63 and p73 can perform certain “p53-like activities. ” Similar to p53, both p63 and p73 can form homo-oligomers, bind DNA, activate transcription from p53-responsive genes, and induce apoptosis (3, 5, 12). However, in contrast to p53, p63 and p73 give rise to multiple functionally distinct protein isoforms, some of which lack the NH2-terminal transactivation domain and can function as “dominant negative” proteins, which block the function of the corresponding full-length proteins. In addition, p63 and p73 are only rarely mutated in the large number of tumors examined to date and are thus unlikely to be classical tumor suppressor genes. However, altered expression of the various isoforms and heterotypic interactions among the different family members may still play a role in tumorigenesis. Also in contrast to p53, severe developmental abnormalities are observed in mice lacking either p63 or p73 and in humans with germ-line p63 mutations. This suggests possible tissue-specific functions for p63 and p73 during development. This article will review the growing compilation of reports addressing similarities and differences between p53, p63, and p73.
Non-iterative Camera Calibration Procedure Using A Virtual Camera

This article presents a method to improve camera calibration by separating determination of the nonlinear calibration parameters from that of the linear ones. We measure correspondences between the distorted image on a camera target and a flexible undistorted calibration pattern displayed on a TFT monitor. Using these correspondences the image of the camera may be projected onto the plane of the calibration pattern to remove the distortion. We prove that this projection follows the principles of a pinhole camera and call it virtual camera. Using the undistorted images of the virtual camera for traditional camera calibration methods, linear camera parameters can be calculated with a 7.5% to 39.5%
Protective Aptitude of Annexin A1 in Arterial Neointima Formation in Atherosclerosis-Prone Mice—Brief Report

Objective— Restenosis as a consequence of arterial injury is aggravated by inflammatory pathways. Here, we investigate the role of the proresolving protein annexin A1 (AnxA1) in healing after wire injury. Approach and Results— Apoe−/− and Apoe−/−Anxa1−/− mice were subjected to wire injury while fed a high-cholesterol diet. Subsequently, localization of AnxA1 and AnxA1 plasma levels were examined. AnxA1 was found to localize within endothelial cells and macrophages in the neointima. Levels of AnxA1 in the plasma and its lesional expression negatively correlated with neointima size, and in the absence of AnxA1, neointima formation was aggravated by the accumulation and proliferation of macrophages. In contrast, reendothelialization and smooth muscle cell infiltration were not affected in Apoe−/−Anxa1−/− mice. Conclusions— AnxA1 is protective in healing after wire injury and could, therefore, be an attractive therapeutic compound to prevent from restenosis after vascular damage.
Performance of multi-user asynchronous chaos-based communication systems through m-distributed fading channel

The performance of chaos-based DS-CDMA communication system over an m-distributed fading channel is evaluated. The chaos synchronization is assumed and a coherent reception in multi-user case is considered. Based on the Rician approximation of the energy distribution, an exact analytical expression of the bit error rate is derived. Many chaotic maps are used in order to demonstrate the exactitude of our analytical approach. Analytical and simulated results are presented and compared.
Allele and locus‐specific differences in cell surface expression and the association of HLA class I heavy chain with β2‐microglobulin: differential effects of inhibition of glycosylation on class I subunit association

The assembly of HLA class I antigens, and the contribution of the single N‐linked glycan to this process were examined. We observed a requirement for N‐linked glycosylation in the proper assembly and surface expression of HLA‐B locus products in particular, although considerable variation was seen within the allelic series of the HLA‐A and B loci. We conclude that the single N‐linked glycan can contribute in a major way to that conformation of the heavy (H) chain which is competent to associate with the light chain β2‐microglobulin, and that the presence, rather than the type, of carbohydrate chain is important in this respect.
Effects of Mitomycin C in Early Conjunctival Inflammation after Pterygium Surgery

ABSTRACT Purpose: The purpose of this study was to compare inflammatory events and graft characteristics 1 month and 6 months after conjunctival limbal autograft (CLAU) with and without intraoperative mitomycin C (MMC). Methods: This study included 69 eyes of 69 patient’s eyes with pterygium. Clinical data concerning patient demography, preoperative examination including pterygium morphology, recurrence clinical assessment, and complications after CLAU with (MMC+) and without (MMC−) intraoperative MMC were all registered at 1 month and 6 months after surgery. Results: Thirty-five eyes were included in MMC+ and 34 in MMC−. Preoperative data were similar in both groups (Student’s t test and Fisher’s exact test; p > 0.05). Thirty-four (49.6%) eyes in the whole sample showed at least one inflammatory complication at 1 month after surgery. MMC− group showed a significantly higher number of cases with complications (p < 0.001; Chi2 test) (MMC+ 28.5%; MMC− 70.5%). No patients presented clinical recurrence at 1 month after surgery. The examination revealed a higher incidence of clinical hyperemia surrounding the surgical site and graft contraction on the host site on the MMC− group, both with statistical signification (p < 0.001; Chi2 test). Although the hemorrhages were less frequent in the MMC− group, there were no significant differences between the two groups (p > 0.05; Chi2 test). Pyogenic granuloma developed at the surgical site in three eyes (4.37%), two of those granulomas were at the MMC− group (p > 0.05). Tendency for recurrences was significantly different between both groups (p = 0.0001; Fisher’s exact test) at the end of 6 months. Thirteen (38%) eyes showed recurrence in MMC− and no cases were displayed in MMC+. Presence of at least 1 inflammatory event was only seen in 16 (23%) cases, all of them in MMC−. Specifically, 15 (44%) eyes showed hyperemia and one (3%) eye presented conjunctival hemorrhages. No new cases of pyogenic granuloma or graft contraction were seen at this time point in both groups. Hyperemia was the only specific event with significant differences between MMC− and MMC+ (p = 0.0001; Fisher’s exact test) at 6 months after surgery. Conclusion: The eyes receiving intraoperative MMC after CLAU seem to present less hyperemia and graft contraction after surgery than those that did not receive MMC as an adjuvant factor. Intraoperative MMC could be associated with a lower recurrence rates.
Low-Fat Diet and Skin Cancer Risk: The Women's Health Initiative Randomized Controlled Dietary Modification Trial

Background: Large cohort studies have reported no relationship between dietary fat and nonmelanoma skin cancer (NMSC), although a low-fat diet intervention reduced NMSC risk in a small clinical trial. In animal studies, skin tumor development has been reduced by low-fat diet. We evaluated the effect of a low-fat dietary pattern on NMSC and melanoma in the Women's Health Initiative Dietary Modification trial. Methods: Postmenopausal women aged 50 to 79 years (n = 48,835) were randomly assigned to the low-fat dietary pattern intervention (n = 19,541) or comparison group (n = 29,294). The intervention goals included decreasing fat intake to 20% or less of calories, increasing vegetable and fruit intake, and increasing grain intake. Self-reported incident NMSC (n = 4,907) and physician-adjudicated incident melanoma (n = 279) were ascertained every 6 months. Results: Over 8.1 years of follow-up, the low-fat diet intervention did not affect overall incidence of NMSC [HR 0.98; 95% confidence interval (CI), 0.92–1.04] or melanoma (HR, 1.04; 95% CI, 0.82–1.32). In subgroup analyses of melanoma risk, baseline fat intake interacted significantly with group assignment (Pinteraction = 0.006). Among women with higher baseline fat intake, the dietary intervention significantly increased risk (HR, 1.48; 95% CI, 1.06–2.07), whereas, among women with lower baseline fat intake, the intervention tended to reduce melanoma risk (HR, 0.72; 95% CI, 0.50–1.02). Conclusions: In this large randomized trial, a low-fat dietary pattern did not affect overall incidence of NMSC or melanoma. Impact: A low-fat diet does not reduce incidence of NMSC, but an interaction between baseline fat intake and dietary intervention on melanoma risk warrants further investigation. Cancer Epidemiol Biomarkers Prev; 22(9); 1509–19. ©2013 AACR.
Power and thermal management in massive multicore chips: Theoretical foundation meets architectural innovation and resource allocation

Continuing progress and integration levels in silicon technologies make possible complete end-user systems consisting of extremely high number of cores on a single chip targeting either embedded or high-performance computing. However, without new paradigms of energy- and thermally-efficient designs, producing information and communication systems capable of meeting the computing, storage and communication demands of the emerging applications will be unlikely. The broad topic of power and thermal management of massive multicore chips is actively being pursued by a number of researchers worldwide, from a variety of different perspectives, ranging from workload modeling to efficient on-chip network infrastructure design to resource allocation. Successful solutions will likely adopt and encompass elements from all or at least several levels of abstraction. Starting from these ideas, we consider a holistic approach in establishing the Power-Thermal-Performance (PTP) trade-offs of massive multicore processors by considering three inter-related but varying angles, viz., on-chip traffic modeling, novel Networks-on-Chip (NoC) architecture and resource allocation/mapping.
Early clinical experience with risperidone long-acting injection: a prospective, 6-month follow-up of 100 patients.

BACKGROUND The use of risperidone long-acting injection (RLAI) is reasonably well supported by controlled studies. Little is known about treatment outcomes in patients receiving RLAI in clinical practice. METHOD All prescribers in the South London and Maudsley Trust, London, United Kingdom, were informed that RLAI could be ordered for suitable patients with a DSM-IV diagnosis of schizophrenia or schizo-affective disorder: those known to be noncompliant with oral atypical antipsychotics and those intolerant of the adverse effects of conventional depot antipsychotics. Prescribers provided treatment and clinical progress data at the time of each prescription. Data collected included reason for prescribing RLAI, Clinical Global Impressions scale (CGI) score, inpatient or out-patient status, and details of all medications prescribed. All treatment discontinuations were investigated. The study was conducted from August 2002 to August 2003. RESULTS Outcome could be determined for 100 subjects. Seventy-nine subjects (79%) were hospitalized when RLAI was initially prescribed. Mean duration of stay before RLAI initiation was 97 days (range, 0-1492 days). Most subjects were switched to RLAI from oral atypical (58%) or conventional depot (28%) antipsychotics. The main reason given for prescribing RLAI was poor patient acceptability of previous treatments (79%). Overall, 51% of the subjects discontinued RLAI. The main reason for discontinuation was lack of effect (24 subjects). No patient-related factor predicted outcome. CGI scores improved from a mean of 4.7 to 3.6 over the study period (p <.001). Overall, 61 subjects (61%) showed an improvement in CGI scores between baseline and endpoint. Antipsychotic coprescriptions were reduced from 71% of subjects to 8%. In completers, 23 (61%) of 38 subjects beginning RLAI as inpatients were discharged. The modal dose of RLAI was 25 mg every 2 weeks. CONCLUSION RLAI was moderately effective in clinical practice as judged by attrition from treatment. CGI score changes and discharge rates also suggest moderate effectiveness. RLAI was well tolerated. Antipsychotic coprescription was infrequent.
Testing the feasibility of intra-operative sentinel lymph node touch imprint cytology.

INTRODUCTION Sentinel lymph node biopsy is emerging as the new standard for axillary staging in breast cancer. Intra-operative assessment of the sentinel lymph nodes allows immediate completion of axillary dissection during the same anaesthetic. This project was a quality assurance practice to establish feasibility, time-to-report, as well as accuracy of performing intra-operative assessment of sentinel lymph nodes using touch imprint cytology in our centre. PATIENTS AND METHODS This prospective audit included 146 sentinel lymph nodes from 74 consecutive patients with invasive breast cancer. All patients underwent axillary sentinel lymph node biopsy using combined blue dye and radiocolloid technique. Results of intra-operative touch imprint cytology using haematoxylin and eosin staining were compared with the definitive histopathology results. RESULTS Mean time to report touch imprint cytology was 25.7 +/- 6.4 min (range, 15-40 min). Histopathology demonstrated metastasis in 25 sentinel nodes from 17 (23%) patients. Intra-operative touch imprint cytology detected 15 nodes in 11 patients, giving a sensitivity of 60% (nodes) and 66.7% (patients) and specificity of 99.2% (nodes) and 98.2% (patients) based on the number of nodes and patients involved, respectively. Touch imprint cytology failed to show metastatic involvement in 10 nodes from 6 patients; of these, five nodes had micrometastasis (< 2 mm) and the other five had macrometastasis. One touch imprint cytology positive node contained isolated tumour cells only. Using intra-operative touch imprint cytology made a change in treatment of 11(14.9%) patients, and spared second axillary procedure in 7 (9.4%) patients. CONCLUSIONS Intra-operative sentinel lymph node assessment using touch imprint cytology is feasible within a busy NHS practice. We now offer touch imprint cytology to patients following appropriate counselling.