Miracle-dz/UniFAR-FTUs huggingface dataset:
: Instant Social Networking under Censorship

Social media websites are blocked in many regimes where Internet censorship is applied. In this paper, we introduce Mailet, an unobservable transport proxy which enables the users to access social websites by email applications. Without assuming the Mailet servers are trustworthy, Mailet can support the services requiring privileges without having the complete credential. Particularly, the credential is split and distributed in two Mailet servers, and neither of them can recover the credential alone. To recover the credential in a TLS record message, we propose a highly efficient Galois/Counter Mode(GCM) based secure computation, which can enable the two servers to conceal their separate credential copies in the computation. We implemented a prototype for Twitter.com to demonstrate the usability and security of Mailet.
Applying autonomic computing concepts to parallel computing using intelligent agents

The work reported in this paper is motivated by the fact that there is a need to apply autonomic computing concepts to parallel computing systems. Advancing on prior work based on intelligent cores [36], a swarm-array computing approach, this paper focuses on ‘Intelligent agents’ another swarm-array computing approach in which the task to be executed on a parallel computing core is considered as a swarm of autonomous agents. A task is carried to a computing core by carrier agents and is seamlessly transferred between cores in the event of a predicted failure, thereby achieving self-ware objectives of autonomic computing. The feasibility of the proposed swarm-array computing approach is validated on a multi-agent simulator.
Attenuation of postischemic cerebral hypoperfusion by the 21-aminosteroid U74006F.

The ability of the nonglucocorticoid 21-aminosteroid U74006F, a potent inhibitor of iron-dependent lipid peroxidation, to antagonize progressive brain hypoperfusion after a 5-minute episode of global brain ischemia was examined in alpha-chloralose-anesthetized cats. Immediately after a 5-minute episode of near-total tourniquet-induced brain ischemia, cortical blood flow returned to normal or above normal. Thereafter, cortical blood flow fell progressively to a level 71.7% below normal by 3 hours after ischemia. In contrast, in cats that received 1 mg/kg i.v. U74006F 15 minutes after the ischemic episode, cortical blood flow remained significantly greater than that seen in vehicle-treated cats. At 3 hours, cortical blood flow had declined by only 45.7% (p less than 0.04 compared with vehicle). In addition, U74006F treatment significantly improved postischemic maintenance of blood pressure and recovery of somatosensory evoked potentials and reduced postischemic arterial blood acidosis. U74006F had no effect on cortical blood flow, somatosensory evoked potentials, or blood pressure in nonischemic cats. Our results suggest that U74006F may be useful in the early treatment of global cerebral ischemia.
Combining Procedural and Declarative Knowledge in a Graphical Architecture

A prototypical cognitive architecture defines a memory architecture embodying forms of both procedural and declarative memory, plus their interaction. Reengineering such a dual architecture on a common foundation of graphical models enables a better understanding of both the substantial commonalities between procedural and declarative memory and the subtle differences that endow each with its own special character. It also opens the way towards blended capabilities that go beyond existing architectural memories.
Lead Poisoning: Myoclonus Following Welding Exposure.

1. Movement Disorders Center. Department of Neurology. School of Medicine. Universidade de São Paulo. São Paulo. Brazil. 2. Department of Radiology and Medical Imaging. School of Medicine San Jose. Bogota. Colombia. 3. Instituto de Epilepsia y Parkinson del Eje Cafetero SA. Pereira. Colombia.  Autor correspondente: Rubens Gisbert Cury. rubens_cury@terra.com. br Recebido: 04 de julho de 2017 Aceite: 19 de outubro de 2017 | Copyright © Ordem dos Médicos 2017 Lead Poisoning: Myoclonus Following Welding Exposure
Dredging Impacts on Delaware Estuary Tides

This study summarizes historic dredging activities and historic tidal trends in the Delaware Estuary. Since 1910, large-scale dredging and maintenance projects in the Delaware Estuary have increased navigation channel depths from approximately 20 ft (6.1 m) to 40 ft (12.2 m). Upper Delaware Estuary tidal ranges also increased approximately two-fold during this period. The potential influence of dredging activities on Delaware Estuary tides is examined through application of variable depth hydrodynamic models. The models suggest that historic increases in upper Estuary tidal ranges are associated with the deepening of middle/upper Estuary navigation channels. The models also suggest that competing effects of bottom friction and upstream `funneling' regulate tidal amplification in the Delaware Estuary and other similar systems.
Solid state coordination chemistry: structural consequences of variations in tether length in the oxovanadium-copper-bisterpy-[O3P(CH2)nPO3]4- system, n= 1-6 (bisterpy = 2,2':4',4'':2'',2'''-quarterpyridyl-6',6''-di-2-pyridine).

Hydrothermal reactions of Na3VO4, an appropriate Cu(II) source, bisterpy and an organodiphosphonate, H2O3P(CH2)nPO3H2 (n = 1-6) yielded a family of materials of the type [Cu2(bisterpy)]4+/VxOy(n-)/[O3P(CH2)nPO3]4-. This family of bimetallic oxides is characterized by an unusual structural diversity. The oxides [[Cu2(bisterpy)]V2O4[O3PCH2PO3H]2] (1), [[Cu2(bisterpy)(H2O)]VO2[O3P(CH2)3PO3][HO3P(CH2)3PO3H2]] (4) and [[Cu2(bisterpy)]V2O4[O3P(CH2)6PO3H]2]. 2H2O (7.2H2O) are one-dimensional, while [[Cu2(bisterpy)(H2O)2]V2O4[O3P(CH2)2PO3][HO3P(CH2)2PO3H]2] (2), [[Cu2(bisterpy)]V4O8[O3P(CH23PO3]2].4H2O (3.4H2O) and [[Cu2(bisterpy)]V2O4(OH)2[O3P(CH2)4PO3]]. 4H2O (5.4H2O) are two-dimensional. The V(IV) oxide [[Cu2(bisterpy)]V4O4[O3P(CH2)5PO3H]4]. 7.3H2O (6.7.3H2O) provides a relatively unusual example of a three-dimensional bimetallic oxide phosphonate. The structures reveal a variety of V/P/O substructures as building blocks.
Genotypic and phenotypic characterization of Escherichia coli isolates from dogs manifesting attaching and effacing lesions

Thirteen Escherichia coli isolates from dogs manifesting attaching and effacing lesions were characterized genetically with respect to the presence of the following virulence determinants associated with human enteropathogenic E. coli (EPEC): eaeA, encoding the outer membrane protein intimin; eaeB, which is necessary for inducing signal transduction; bfpA, encoding the bundle-forming pilus; and the EAF (stands for EPEC adherence factor) plasmid. These isolates were also analyzed phenotypically with respect to adherence to mammalian cells in vivo and in vitro. Nine of these 13 isolates were found to be eaeA positive by PCR: four of these nine were eaeB positive. The 5' end, but not the 3' end, of the eaeA gene was amplified by PCR when primers derived from the eaeA gene of EPEC were used. Six and eight of these 13 isolates were found to be bfpA positive and EAF positive, respectively. The bfpA gene and EAF locus were found on high-molecular-weight plasmids, whereas the eaeA and eaeB genes were chromosomally located when present. Only one canine E. coli isolate, 4221, which was positive for eaeA, eaeB, bfpA, and EAF, adhered to HEp-2 cells in a localized manner and was positive in the fluorescence actin staining test. The nine eaeA-positive isolates adhered to the mucosal surface of piglet ileal explants and induced some microvillus effacement. However, when tested in experimentally inoculated gnotobiotic piglets, isolate 4221 did not induce attaching and effacing lesions at any level of the intestinal tract. Our results indicate that canine E. coli isolates associated with attaching and effacing lesions share some properties with human EPEC but form a heterogeneous group.
An Optimized Energy Aware Routing (OEAR) Scheme for Mobile Ad Hoc Networks using Variable Transmission Range

Ad hoc Networks (MANETs) are energy constrained since nodes operate with limited battery energy. This not only leads to degradation in performance of the network but also reduces the lifetime of the network and in some cases makes the network partitioned. In order to maximize the lifetime of MANETs, routes having nodes with low energy and nodes with more buffered packets should be avoided. In this paper, a new energy efficient scheme has been proposed which takes into consideration the above mentioned characteristics of nodes. Energy consumption is further optimized by using variable transmission range. Common transmission range is used in existing popular routing protocols like AODV and DSR. Simulations are done in Network Simulator-2. It is shown that the algorithm improves the network energy consumption and increases the lifetime of the network.
A comparison of rapid point-of-care tests for the detection of avian influenza A(H7N9) virus, 2013.

textabstractSix antigen detection-based rapid influenza point-of-care tests were compared for their ability to detect avian influenza A(H7N9) virus. The sensitivity of at least four tests, standardised by viral infectivity (TCID50) or RNA copy number, was lower for the influenza A(H7N9) virus than for seasonal A(H3N2), A(H1N1)pdm09 or other recent avian A(H7) viruses. Comparing detection limits of A(H7N9) virus with Ct values of A(H7N9) clinical specimens suggests the tests would not have detected most clinical specimens.
ClC3 Is a Critical Regulator of the Cell Cycle in Normal and Malignant Glial Cells

Although most brain cells are postmitotic, small populations of progenitor or stem cells can divide throughout life. These cells are believed to be the most likely source for primary brain malignancies including gliomas. Such tumors share many common features with nonmalignant glial cells but, because of their insidious growth, form cancers that are typically incurable. In studying the growth regulation of these tumors, we recently discovered that glioma cell division is preceded by a cytoplasmic condensation that we called premitotic condensation (PMC). PMC represents an obligatory step in cell replication and is linked to chromatin condensation. If perturbed, the time required to complete a division is significantly prolonged. We now show that PMC is a feature shared more commonly among normal and malignant cells and that the reduction of cell volume is accomplished by Cl− efflux through ClC3 Cl− channels. Patch-clamp electrophysiology demonstrated a significant upregulation of chloride currents at M phase of the cell cycle. Colocalization studies and coimmunoprecipitation experiments showed the channel on the plasma membrane and at the mitotic spindle. To demonstrate a mechanistic role for ClC3 in PMC, we knocked down ClC3 expression using short hairpin RNA constructs. This resulted in a significant reduction of chloride currents at M phase that was associated with a decrease in the rate of PMC and a similar impairment of DNA condensation. These data suggest that PMC is an integral part of cell division and is dependent on ClC3 channel function.
Automatic Methods for Continuous State Space Abstraction

Reinforcement learning algorithms are often tasked with learning an optimal control policy in a continuous state space. Since it is infeasible to learn the optimal action to take for every possible observation in a continuous state space, useful abstractions of the space must be constructed and subsequently learned on. Abstraction techniques that generalize the space into very few abstract states must take care to avoid creating an abstraction that prevents learning the optimal policy. Many commonly used abstractions, such as CMAC can take considerable effort to tune to ensure a learnable abstraction is created. In this work we propose three methods that derive state abstractions automatically, in part by making use of the dimensionality reduction capability of the RL-SANE algorithm. We show that abstractions derived from these automatic methods can allow a learning algorithm to converge to the optimal policy faster than with a fixed abstraction. Additionally, these techniques are able to break the space into very few abstract states, further facilitating rapid learning.
Thr 163 Phosphorylation Causes Mcl-1 Stabilization when Degradation Is Independent of the Adjacent GSK3-Targeted Phosphodegron, Promoting Drug Resistance in Cancer

The antiapoptotic Bcl-2 family member Mcl-1 is a PEST protein (containing sequences enriched in proline, glutamic acid, serine, and threonine) and is subject to rapid degradation via multiple pathways. Impaired degradation leading to the maintenance of Mcl-1 expression is an important determinant of drug resistance in cancer. Phosphorylation at Thr 163 in the PEST region, stimulated by 12-O-tetradecanoylphorbol acetic acid (TPA)-induced activation of extracellular signal-regulated kinase (ERK), is associated with Mcl-1 stabilization in BL41-3 Burkitt lymphoma cells. This contrasts with the observation that Thr 163 phosphorylation in normal fibroblasts primes glycogen synthase kinase (GSK3)-induced phosphorylation at Ser 159, producing a phosphodegron that targets Mcl-1 for degradation. In the present follow-up studies in BL41-3 cells, Mcl-1 degradation was found to be independent of the GSK3-mediated pathway, providing a parallel to emerging findings showing that Mcl-1 degradation through this pathway is lost in many different types of cancer. Findings in Mcl-1-transfected CHO cells corroborated those in BL41-3 cells in that the GSK3-targeted phosphodegron did not play a major role in Mcl-1 degradation, and a phosphomimetic T163E mutation resulted in marked Mcl-1 stabilization. TPA-treated BL41-3 cells, in addition to exhibiting Thr 163 phosphorylation and Mcl-1 stabilization, exhibited an ∼10-fold increase in resistance to multiple chemotherapeutic agents, including Ara-C, etoposide, vinblastine, or cisplatin. In these cancer cells in which Mcl-1 degradation is not dependent on the GSK3/phosphodegron-targeted pathway, ERK activation and Thr 163 phosphorylation are associated with pronounced Mcl-1 stabilization and drug resistance – effects that can be suppressed by inhibition of ERK activation.
Folding of a single domain protein entering the endoplasmic reticulum precedes disulfide formation

The relationship between protein synthesis, folding, and disulfide formation within the endoplasmic reticulum (ER) is poorly understood. Previous studies have suggested that pre-existing disulfide links are absolutely required to allow protein folding and, conversely, that protein folding occurs prior to disulfide formation. To address the question of what happens first within the ER, that is, protein folding or disulfide formation, we studied folding events at the early stages of polypeptide chain translocation into the mammalian ER using stalled translation intermediates. Our results demonstrate that polypeptide folding can occur without complete domain translocation. Protein disulfide isomerase (PDI) interacts with these early intermediates, but disulfide formation does not occur unless the entire sequence of the protein domain is translocated. This is the first evidence that folding of the polypeptide chain precedes disulfide formation within a cellular context and highlights key differences between protein folding in the ER and refolding of purified proteins.
Automatic synthesis of composable sequential quantum Boolean circuits

This paper presents a methodology to transfer self-timed circuit specifications into sequential quantum Boolean circuits (SQBCs) and composable SQBCs (CQBCs). State graphs (SGs) are used to describe the behaviors of self-timed circuits and then are translated into SQBCs based on Toffoli gates. The concept of IP (intellectual property) reuse is applied to the constructed SQBCs to produce reusable and composable quantum Boolean circuits (CQBCs). Therefore, these reusable CQBCs as basic modular components can be exploited to construct more complicated quantum Boolean circuits. A set of self-timed components is successfully and automatically synthesized into CQBCs by our methodology. These CQBCs can be used as building blocks to compose control-path components of self-timed systems.
EVALUATION OF CENTRAL NERVOUS SYSTEM ACTIVITIES OF CITRUS MAXIMA LEAF EXTRACT ON RODENTS

Citrus maxima is a traditional medicine used to treat astringent, constipation, hypnotic, inflammation and antiseptic. Therefore, we aimed to evaluate Central Nervous System activities of ethanolic extract of Citrus maxima (EECM). 200 and 400mg/kg of EECM were orally administrated on depressant, anxiolytic, convulsant, hypnotic and muscle relaxant experimental animals. In the loco motor test, EECM increased the numbers of rearing, central motor and ambulation was reduced. The number of entries and time spent in the open arm were increased, decreased locomotion in elevated-plus-maze and actophotometer test. EECM protected the mice against the pentylenetetrazole and strychnine induced convulsion in a dose dependent manner. Treatment with EECM significantly reduced the duration of the tonic hind limb extension, increased hypnotics time and decreased motor co-ordination of experimental animals. This study concludes C.maxima will be an alternative source for psychiatric and neurological disorders.
Recycling of the endoplasmic reticulum/Golgi intermediate compartment protein ERGIC-53 in the secretory pathway.

out the cytoplasm following IQ treatment, while stacks appear as large discrete aggregates by immunofluorescence in intact cells after removal of IQ [12,13]. This assay exploits the ability to distinguish the relative distribution of VGMs and the stacks of Golgi cisternae by immunofluorescence microscopy using Golgi-specific antibodies. Electron microscopy has been used to confirm that the large aggregates of Golgi membranes are indeed stacks of cisternae. This assay is quantitative and relatively simple, and therefore provides a unique opportunity to identify the cytoplasmic proteins that catalyse the fusion and assembly of VGMs into stacks of cisternae [20]. The effects of IQ on the organization of Golgi stacks in whole cells mimic the dynamics of Golgi membranes seen in association with the events of the cell cycle. It is likely, therefore, that proteins identified from this assay using IQ as an inhibitor of stack formation will help our understanding of the process by which Golgi stacks are assembled and the mechanism by which their organization is regulated during the cell cycle.
Statins and Cardiovascular Risks

Multiple clinical trials have demonstrated the benefits of 3-hydroxy3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) in reducing the risk of death and nonfatal ischemic cardiovascular events in both stable coronary heart diseases as well as following acute coronary syndromes (ACSs). Recently, statins have been shown to reduce cardiovascular events for patients undergoing major noncardiac surgery. This chapter reviews the cellular mechanism ofmyocardial infarction (MI), past clinical evidence supporting the use of statins for the primary and secondary prevention of coronary heart disease, and recent clinical trials that support the use of statins perioperatively.
Institute of Physics Publishing Journal of Micromechanics and Microengineering a Review of Microvalves

This review gives a brief overview of microvalves, and focuses on the actuation mechanisms and their applications. One of the stumbling blocks for successful miniaturization and commercialization of fully integrated microfluidic systems was the development of reliable microvalves. Applications of the microvalves include flow regulation, on/off switching and sealing of liquids, gases or vacuums. Microvalves have been developed in the form of active or passive microvalves employing mechanical, non-mechanical and external systems. Even though great progress has been made during the last 20 years, there is plenty of room for further improving the performance of existing microvalves. (Some figures in this article are in colour only in the electronic version)
What makes people talk about antibiotics on social media? A retrospective analysis of Twitter use

Objectives Social media has reshaped individual and institutional communication. The unrestricted access to spontaneous views and opinions of society can enrich the evaluation of healthcare interventions. Antimicrobial resistance has been identified as a global threat to health requiring collaboration between clinicians and healthcare users. We sought to explore events and individuals influencing the discourse about antibiotics on Twitter. Methods A web-based tool (www.topsy.com) was used to detect daily occurrences of the word ‘antibiotic’ from 24 September 2012 to 23 September 2013 in worldwide Tweets. Activity peaks (message frequency over three times that of baseline) were analysed to identify events leading to the increase. Results Of 135 billion messages posted during the study period, 243 000 (0.000002%) referred to ‘antibiotic’. The greatest activity increases appeared after: (i) the UK Chief Medical Officer's (CMO's) declaration of antimicrobial resistance as a national risk (January 2013 and March 2013); (ii) the release of the US CDC's report on antimicrobial resistance (September 2013); and (iii) the US FDA announcement on azithromycin safety concerns (March 2013). The CMO report in March reached an estimated worldwide audience of 20 million users in a single day. However, the frequency of antibiotic Tweets returned to basal levels within 48 h of all four peaks in activity. Conclusions Institutional events can rapidly amplify antibiotic discussions on social media, but their short lifespan may hinder their public impact. Multipronged strategies may be required to prolong responses. Developing methods to refine social media monitoring to evaluate the impact and sustainability of societal engagement in the antimicrobial resistance agenda remains essential.
The efficiency of a sedative or analgesic supplement to periprostatic nerve blockage for pain control during transrectal ultrasound-guided prostate biopsy – a prospective, randomized, controlled, double blind study

Introduction The aim was to examine the effect of a sedative or analgesic supplement to periprostatic nerve blockage (PNB) on pain reduction during probe insertion and needle penetration in patients undergoing transrectal ultrasound (TRUS)-guided prostate biopsy. We also investigated the effects of this procedure on the positive response rate in re-biopsy. Material and methods One hundred TRUS-guided prostate biopsy patients due to prostate-specific antigen (PSA) levels higher than 2.5 ng/ml and/or abnormal rectal examination findings were evaluated. Group 1 (PNB) was given periprostatic lidocaine injection before the procedure. Group 2 (analgesic) was given tramadol and PNB. Group 3 (sedative) was given midazolam and PNB. Group 4 (control) was not given any anaesthesia or analgesics. Pain scores were assessed during probe insertion and needle penetration by a visual analogue scale. Results During probe insertion, the mean pain score of the sedative group was lower than that of the control, analgesic and PNB groups (p < 0.001, p = 0.009, and p < 0.001, respectively). During needle penetration, the mean pain score of the control group was higher than that of the other groups (p < 0.001). The rate of positive response to re-biopsy was found to be 56% in the control group and between 92% and 100% in the other three groups (p < 0.001). Conclusion According to our results, it can be concluded that midazolam, given supplementary to PNB, contributes as an effective and safe alternative for pain control during both probe insertion and penetration of the biopsy needle into the prostate capsule; however, tramadol supplement does not provide any additional contributions.