Miracle-dz/UniFAR-FTUs huggingface dataset:
Title (120 characters or less): Vitamin D3 regulates estrogen’s action and affects mammary epithelial organization in cultures

11 Vitamin D3 (vitD3) and its active metabolite, calcitriol (1,25-(OH) 2 D 3 ), affect multiple tissue types by 12 interacting with the vitamin D receptor (VDR). Although vitD3 deficiency has been correlated with 13 increased incidence of breast cancer and less favorable outcomes across ethnic groups and latitudes, 14 randomized human clinical trials have yet to provide conclusive evidence on the efficacy of vitD3 in 15 treating and/or preventing breast cancer. When considering that carcinogenesis is “development gone 16 awry”, it becomes imperative to understand the role of vitD3 during breast development. Mammary 17 gland development in VDR KO mice is altered by increased ductal elongation and lateral branching 18 during puberty, precocious and increased alveologenesis at pregnancy and delayed post-lactational 19 involution. These developmental processes are largely influenced by mammotropic hormones, i.e., 20 ductal elongation by estrogen, branching by progesterone and alveologenesis by prolactin. However, 21 research on vitD3’s effects on mammary gland morphogenesis focused on cell proliferation and 22 apoptosis in 2D culture models and utilized supra-physiological doses of vitD3, conditions that spare the 23 microenvironment in which morphogenesis takes place. Here, using two 3D culture models, we 24 investigated the role of vitD3 in mammary epithelial morphogenesis. We found that vitD3 interferes 25 with estrogen’s actions on T47D human breast cancer cells in 3D differently at different doses, and 26 recapitulates what is observed in vivo . Also, vitD3 can act autonomously and affect the organization of 27 MCF10A cells in 3D collagen matrix by influencing collagen fiber organization. Thus, we uncovered how 28 vitD3 modulates mammary tissue organization independent of its already known effects on cell 29 proliferation. In this study, we have utilized two different 3D cell cultures models to investigate vitD3’s role in mammary gland morphogenesis. We observed that calcitriol constrains E2’s actions on the organization
REFLECTIONS ON THE SPATIOTEMPORAL ASPECTS OF THE QUANTUM WORLD

The proper resolution of the so-called measurement problem requires a "top-down" conception of the quantum world that is opposed to the usual "bottom-up" conception, which builds on an intrinsically and maximally differentiated manifold. The key to that problem is that the fuzziness of a variable can manifest itself only to the extent that less fuzzy variables exist. Inasmuch as there is nothing less fuzzy than the metric, this argues against a quantum-gravity phenomenology and suggests that a quantum theory of gravity is something of a contradiction in terms — a theory that would make it possible to investigate the physics on scales that do not exist, or to study the physical consequences of a fuzziness that has no physical consequences, other than providing a natural cutoff for the quantum field theories of particle physics.
Eclipsing Light-Curve Asymmetry for Black-Hole Accretion Flows

We propose an eclipsing light-curve diagnosis for black-hole accretion flows. When emission from an inner accretion disk around a black hole is occulted by a companion star, the observed light curve becomes asymmetric at ingress and egress on a time scale of 0.1-1 seconds. This light-curve analysis provides a means of verifying the relativistic properties of the accretion flow, based on the special/general relativistic effects of black holes. The ``skewness'' for the eclipsing light curve of a thin disk is $\sim 0.08$, whereas that of a slim disk is $\sim 0$, since the innermost part is self-occulted by the disk's outer rim.
Resonant spectroscopy of II-VI self-assembled quantum dots: Excited states and exciton-longitudinal optical phonon coupling

Using resonantly excited photoluminescence (PL) along with photoluminescence excitation (PLE) spectroscopies, we study the carrier excitation processes in $\mathrm{CdTe}∕\mathrm{ZnTe}$ and $\mathrm{CdSe}∕\mathrm{ZnSe}$ self-assembled quantum dots (QD's). PLE spectra of single $\mathrm{CdTe}$ QD's reflect two major mechanisms for carrier excitation: The first, associated with the presence of sharp and intense lines in the spectrum, is a direct excited-state\char21{}ground-state transition. The second, associated with the appearance of up to four much broader excitation lines, is a longitudinal optical (LO) phonon-assisted absorption directly into the QD ground states. LO phonons with energies of both QD's and $\mathrm{ZnTe}$ barrier material are identified in the PLE spectra. Resonantly excited PL measurements for the QD ensemble as a function of excitation energy makes it possible to separate the contributions of these two mechanisms. We find that for $\mathrm{CdTe}$ QD's the distribution of excited states coupled to the ground states reflects the energy distribution of the QD emission, but shifted up in energy by $100\phantom{\rule{0.3em}{0ex}}\mathrm{meV}$. This large splitting between excited and ground states in $\mathrm{CdTe}$ QD's suggests strong spatial confinement. In contrast, the LO phonon-assisted absorption shows significant size selectivity. In the case of $\mathrm{CdTe}$ dots the exciton-LO phonon coupling is strongly enhanced for smaller-sized dots which have higher emission energies. In contrast, for $\mathrm{CdSe}$ QD's the strength of exciton-LO phonon coupling is nearly uniform over the whole ensemble\char22{}that is, the dot energy distribution determines the intensities of LO phonon replicas. We show that for $\mathrm{CdTe}$ QD's after annealing, that is, after an increase in the average dot size, the exciton-LO phonon interaction reflects the dot energy distribution, as observed for $\mathrm{CdSe}$ QD's.
Chiral light-front perturbation theory and the flavor dependence of the light-quark nucleon sea

The light-quark flavor dependence of the proton sea has been of great interest for many years because of its close connection with non-perturbative effects. One hypothesis is that the sea arises from the pion cloud of the proton. We make precise predictions based on the pion cloud idea for an anticipated future measurement. This is achieved by applying light cone perturbation theory and experimental constraints to a chiral Lagrangian so that the relevant Fock-space components of the nucleon wave function are computed with reasonable accuracy. Existing experimental information regarding the light flavor sea is studied, and predictions, including uncertainties, for future experimental results are provided. Future experiments will either confirm or rule out the idea that the pion cloud provides the flavor dependence of the proton's sea quark distribution, and have profound implications for understanding the nucleon-nucleon force.
On the Geometry of Curvature Radiation and Implications for Subpulse Drifting

The phenomenon of subpulse drifting offers unique insights into the emission geometry of pulsars, and is commonly interpreted in terms of a rotating carousel of “spark” events near the stellar surface. We develop a detailed geometric model for the emission columns above a carousel of sparks that is entirely calculated in the observer’s inertial frame, and which is consistent with the well-understood rotational effects of aberration and retardation. We explore the observational consequences of the model, including (1) the appearance of the reconstructed beam pattern via the cartographic transform, and (2) the morphology of drift bands and how they might evolve as a function of frequency. The model, which is implemented in the software package PSRGEOM, is applicable to a wide range of viewing geometries, and we illustrate its implications using PSRs B0809+74 and B2034+19 as examples. Some specific predictions are made with respect to the difference between subpulse evolution and microstructure evolution, which provides a way to further test our model.
Observational Requirements for High‐Fidelity Reverberation Mapping

We present a series of simulations to demonstrate that high‐fidelity velocity‐delay maps of the emission‐line regions in active galactic nuclei (AGNs) can be obtained from time‐resolved spectrophotometric data sets like those that will arise from the proposed Kronos satellite. While previous reverberation‐mapping experiments have established the size scale R of the broad emission‐line regions from the mean time delay τ = R/c between the line and continuum variations and have provided strong evidence for supermassive black holes, the detailed structure and kinematics of the broad‐line region remain ambiguous and poorly constrained. Here we outline the technical improvements that will be required to successfully map broad‐line regions by reverberation techniques. For typical AGN continuum light curves, characterized by power‐law power spectra P(f)∝f-α with α = -1.5 ± 0.5, our simulations show that a small UV/optical spectrometer like Kronos will clearly distinguish between currently viable alternative kinematic models. From spectra sampled at time intervals Δt and sustained for a total duration Tdur, we can reconstruct high‐fidelity velocity‐delay maps with velocity resolution comparable to that of the spectra, and delay resolution Δτ ≈ 2Δt, provided that Tdur exceeds the broad‐line region light crossing time by at least a factor of 3. Even very complicated kinematical models, such as a Keplerian flow with superimposed spiral wave pattern, are resolved in maps from our simulated Kronos data sets. Reverberation mapping with Kronos data is therefore likely to deliver the first clear maps of the geometry and kinematics in the broad emission‐line regions 1–100 μas from supermassive black holes.
Revising the Evolutionary Stage of HD 163899: The Effects of Convective Overshooting and Rotation

We revise the evolutionary status of the B-type supergiant HD 163899 based on the new determinations of the mass–luminosity ratio, effective temperature, and rotational velocity, as well as on the interpretation of the oscillation spectrum of the star. The observed value of the nitrogen-to-carbon abundance fixes the value of the rotation rate of the star. Now, more massive models are strongly preferred than those previously considered, and it is very likely that the star is still in the main-sequence stage. The rotationally induced mixing manifests as the nitrogen overabundance in the atmosphere, which agrees with our analysis of the HARPS spectra. Thus, HD 163899 probably belongs to a group of evolved nitrogen-rich main-sequence stars.
Minimum Orbital Period of Precataclysmic Variables

More than 20 precataclysmic variable (pre-CV) systems have now been discovered with very short orbital periods ranging from 250 minutes down to 68 minutes. A pre-CV consists of a white dwarf (WD) or hot subdwarf primary and a low-mass companion star, where the companion star has successfully ejected the common envelope (CE) of the primary progenitor, but mass transfer from the companion star to the primary has not yet commenced. In this short-period range, a substantial fraction of the companion stars are likely to be either brown dwarfs with masses ≲0.07 M⊙ or stars at the bottom of the main sequence (MS; ≲0.1 M⊙). The discovery of these short-period pre-CVs raises the question, what is the shortest possible orbital period of such systems? We ran 500 brown dwarf/low-mass MS models with Modules for Experiments in Stellar Astrophysics that cover the mass range from 0.002 to 0.1 M⊙. We find that the shortest possible orbital period is 40 minutes, with a corresponding brown dwarf mass of 0.07 M⊙ for an age equal to a Hubble time. We discuss the past evolution of these systems through the CE and suggest that many of the systems with present-day WD primaries may have exited the CE with the primary as a helium-burning hot subdwarf. We also characterize the future evolution of the observed systems, which includes a phase as CVs below the conventional period minimum.
Microstructural and transport properties of superconducting FeTe0.65Se0.35 crystals

The issue concerning the nature and the role of microstructural inhomogeneities in iron chalcogenide superconducting crystals of FeTe0.65Se0. 35 and their correlation with transport properties of this system was addressed. The presented data demonstrate that chemical disorder originating from the kinetics of the crystal growth process significantly influences the superconducting properties of an Fe–Te–Se system. Transport measurements of the transition temperature and critical current density performed for microscopic bridges allow us to deduce the local properties of a superconductor with microstructural inhomogeneities, and significant differences were noted. The variances observed in the local properties were explained as a consequence of weak superconducting links existing in the studied crystals. The results confirm that the inhomogeneous spatial distribution of ions and small hexagonal symmetry nanoscale regions with nanoscale phase separation also seem to enhance the superconductivity in this system with respect to the values of the critical current density. Magnetic measurements performed in order to determine, in an alternative way, the values of the critical current density, as well as to find the relaxation rate and to check the scaling of the pinning force, confirm the conclusions drawn from the transport measurements.
Positivity violation for the lattice Landau gluon propagator

We present explicit numerical evidence of reflection-positivity violation for the lattice Landau gluon propagator in three-dimensional pure SU(2) gauge theory. We use data obtained at very large lattice volumes (V=80{sup 3},140{sup 3}) and for three different lattice couplings in the scaling region ({beta}=4.2,5.0,6.0). In particular, we observe a clear oscillatory pattern in the real-space propagator C(t). We also verify that the (real-space) data show good scaling in the range t set-membership sign [0,3]fm and can be fitted using a Gribov-like form. The violation of positivity is in contradiction with a stable-particle interpretation of the associated field theory and may be viewed as a manifestation of confinement.
Swift J1644+5734: the EVN view

Abstract A small fraction of Tidal Disruption Events (TDE) produce relativistic jets, evidenced by their non-thermal X-ray spectra and transient radio emission. Here we present milliarcsecond-resolution imaging results on TDE J1644+5734 with the European VLBI Network (EVN). These provide a strong astrometric constraint on the average apparent jet velocity βapp < 0.27, that constrains the intrinsic jet velocity for a given viewing angle.
Spectral synthesis of metallicity gradients in bright early-type galaxies

The main question posed in this investigation is whether spectral synthesis methods confirm the metallicity gradient suggested by the observed Mg2 gradients. To this end, the method of optimized spectral population synthesis is applied to spatially resolved spectroscopic data for a sample of six bright early-type galaxies. The data were obtained at Mont Megantic with a panoramic photon-counting system and cover the 4800-5500 A spectral interval and a spatial interval of more than one effective radius. An overall trend of decreasing metallicity with radial distance was found. The statistical significance of the mean metallicity gradient is consistent with the adopted Fe/H vs Mg2 calibration employed by Couture and Hardy (1988). The results lend confidence to the conclusion that Mg2 gradients are controlled mainly by metallicity. The requirements, limitations, and possible improvements of the method employed here are discussed. 27 refs.
Quasi-continuous dc voltage standard using sinusoidal and pulse-driven Josephson junction arrays

Josephson voltage standards (JVSs) provide a primary realization of the volt, the unit of electromotive force. They generate direct current (dc) voltages up to 10 V and show agreement better than 1 nV V−1 at 10 V. For JVSs based on Josephson junction arrays (JJAs) that are driven by sinusoidal radiofrequency (RF) power, commonly referred to as continuous wave-driven JJAs (CWD JJAs), the minimum voltage that can be generated is limited to the voltage across one Josephson junction (JJ) for practical devices. To achieve this resolution, they may require a perfect JJA chip. JVSs based on a pulse-driven (PD) JJA require high performance electronics (i.e. high bandwidth, low distortion and jitter, pulse shaping filters and large memory) to achieve their minimum and maximum voltage. We have combined two CWD JJAs and two PD JJAs driven by two microwave inputs to one chip to generate quasi-continuous dc voltages up to the sum of the full-scale voltages of both JJAs that are robust to the imperfections of the JJs and have relaxed requirements on the RF electronics driving the JJA, compared to the existing CWD JVSs and PD JVSs, respectively. By use of the JJA chip at the National Measurement Institute Australia, we demonstrate its feasibility to generate voltages up to 1 V. Preliminary evaluation of the system shows that the voltage uncertainty can be 11 nV (k = 2) or better and the theoretical resolution is better than 1 nV from 0 V to 1 V. The main requirement is that all the JJs must have quantum locking ranges with respect to the power and frequency of the RF bias and for the PD JJAs to have a constant voltage over a range of dc bias current. Although this development is not a replacement for existing state-of-the-art JVSs, we anticipate that it will be an alternative fit-for-purpose solution for metrological applications under non-ideal operating conditions or when the components of the state-of-the-art solutions are not available.
A study of work-culture changes at post Covid-19 pandemic in greater Jakarta

This paper presents an examination of culture change in working places due to the Covid-19 pandemic, with a study case in the Greater Jakarta. During the Covid-19 pandemic, most of companies around the world made policy for the employee to work from home (WFH). Implementation of the WFH policy has showed a great success not only in keeping the employee safety and health but also in maintaining employee performance. Now, the pandemic has been shifting to endemic such that working culture is going to change. Health, safety, and flexibility are being keywords of the new working culture. This study assessed the employee perspective about a trend of workplace changing and the needs of supporting facilities. The assessment was done through a survey and analysing the survey data. The result show different types of working system, where 66% work from office, 30% work in hybrid system, 2% work from home, and 2% work from anywhere.
Analysis of the Attachment Process of Bionic Spines Based on the Coupling of Discrete Elements and Multi-body Dynamics

As the only natural satellite of the Earth, the Moon has profound significance for deep space research, and the undifferentiated lunar rock core plays a key role in the investigation of the origin of the Moon. In recent years, there have been numerous deep space sampling techniques, but all of them are at the cost of destroying the sample, while drilling can retain the sample in its original state to the maximum extent. In this paper, based on the reference of the claw spine attachment device at home and abroad, the theoretical modeling of the claw spine piece which plays the role of grasping and attaching is carried out, and the simulation analysis is carried out by the coupling method of discrete element and multi-body dynamics, which provides important guidance for the subsequent experi-ments and the optimized design.
The impact of disposable mask waste pollution in peat soil

The abundance of plastic waste in Indonesia has increased due to the contribution of disposable masks waste during the COVID-19 pandemic. The improper waste management causes the habit of dumping waste in the soil system to still frequently occur. The secondary microplastics from disposable mask waste has the potential to damage soil quality and soil capillary water. Therefore, this study was conducted with the aim of understanding the effects of disposable mask waste in peat soil. The research was conducted by setting up 3 reactors containing peat soil with disposable mask waste buried in it and some plants being grown on it. For 45 days, observations and samples were taken, both filtrate water and soil for analysis. The analysis results showed significant changes in soil properties with changes in the concentration of inorganic matter, organic matter, porosity, bulk density, and water content. Further research needs to be done to see the effects of disposable mask waste in the soil system in real conditions where several confounding variables cannot be controlled.
Motion planning for a piezo‐actuated structure modeling a wingsail

This contribution presents the modeling and the motion planning of a flexible interconnected beam structure representing a wingsail. The structure is equipped with spatially distributed embedded actuators. The solution of the motion planning provides a feedforward control law to realize a desired spatial‐temporal out‐of‐plane deflection trajectory. For this, a systematic flatness‐based methodology is proposed, that allows for an efficient numerical solution exploiting, e.g., finite element approximations. (© 2014 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Realization of low-energy Dirac fermions in (Ir$_{1-x}$Pt$_x$)Te$_2$ superconductors

Superconducting and topological states are two distinct quantum states of matter. Superconductors with topologically nontrivial electronic states provide a platform to study the interplay between them. Recent study revealed that a bulk superconductor PdTe2 is a topological Dirac semimetal with type-II Dirac fermions. However, the Dirac fermions in PdTe2 have no contribution to the superconducting pair because the Dirac points reside far below the Fermi level (EF). Here, we show that in the isostructural compounds (Ir1-xPtx)Te2, the type-II Dirac points can be adjusted to EF by element substitution at x ~ 0.1, for which the bulk superconductivity appears near 2 K. The (Ir1-xPtx)Te2 superconductor with the Dirac points at EF paves the way for studying the relevant exotic physical phenomena such as topological superconductivity in Dirac semimetals.
Optimal experimental demonstration of error-tolerant quantum witnesses

Testing quantum theory on macroscopic scales is a longstanding challenge that might help to revolutionise physics. For example, laboratory tests (such as those anticipated in nanomechanical or biological systems) may look to rule out macroscopic realism: the idea that the properties of macroscopic objects exist objectively and can be non-invasively measured. Such investigations are likely to suffer from i) stringent experimental requirements, ii) marginal statistical significance and iii) logical loopholes. We address all of these problems by refining two tests of macroscopic realism, or `quantum witnesses', and implementing them in a microscopic test on a photonic qubit and qutrit. The first witness heralds the invasiveness of a blind measurement; its maximum violation has been shown to grow with the dimensionality of the system under study. The second witness heralds the invasiveness of a generic quantum operation, and can achieve its maximum violation in any dimension -- it therefore allows for the highest quantum signal-to-noise ratio and most significant refutation of the classical point of view.