Miracle-dz/UniFAR-FTUs huggingface dataset:
Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA

Previously we showed that motility-related protein (MRP-1) is an antigen recognized by monoclonal antibody (mAb) M31-15 inhibiting cell motility and that the sequence of MRP-1 coincides with that of CD9. In the present study, plasmid was constructed in which human MRP-1/CD9 cDNA is expressed under the control of the Abelson murine leukemia virus promoter sequence. The expression plasmid for MRP-1/CD9 was introduced into Chinese hamster ovary cells, human lung adenocarcinoma cell line MAC10 (MRP-1 positive), and human myeloma cell line ARH77 (MRP-1 negative). All of the MRP-1/CD9 (over)expressing clones obtained from these transfected cells showed suppressed cell motility (penetration and phagokinetic track assays) depending on the degree of expression of MRP-1/CD9. Overexpression of MRP-1/CD9 by MAC10 cells resulted in the suppression of cell motility (maximally 73%) associated with considerable inhibition of the cell growth (maximally 48%). However, the inhibition of the growth of MAC10 cells by mAb M31-15 was < 17% at an antibody concentration of 1-5 micrograms/ml, which inhibits cell motility by > 90%. These results suggest that MRP-1/CD9 directly regulates cell motility and may also affect cell growth. Effects on metastasis by the expression of MRP-1 CD9 were investigated with mouse melanoma BL6 cells-BALB/c nu/nu mouse system. Metastatic potential of all transformants expressing MRP-1/CD9 was lower than that of parent BL6 cells.
ADRIS – The Adverse Drug Reactions Information Scheme

Under the Adverse Drug Reactions Information Scheme (ADRIS) data and knowledge relevant to the etiology of adverse drug reactions (ADRs) such as chemical structure of parent compounds, metabolites, covalent adducts, nucleic acid and protein sequences, protein structures, pharmaco-, toxico- and enzyme kinetics, pharmaco- and toxicodynamics, protein interactions, molecular pathways and complexes, as well as toxicological and clinical outcomes, are collected and logically and semantically related. ADRIS reflects the ontological prerequisite for the creation of databases and knowledge discovery systems for the abstraction and visualization of theragenomic concepts. A final outcome is the prediction of ADRs based on a profound knowledge of drug function and the molecular basics for personalized drug safety and eventually, personalized medicine. 2004
Effect of lactose on oro‐cecal transit in lactose digesters and maldigesters

Background The transit time of the small intestine, in addition to lactase activity, may influence lactose digestion and thus play a role in the occurrence of lactose intolerance. The objectives of this study were to investigate the effect of lactose on the oro‐cecal transit time (OCTT) in lactose digesters and maldigesters as well as the possible mechanisms underlying these effects.
Accuracy of magnetic resonance imaging for measuring fetal sheep lungs and other organs

Lung volume measurement by fetal magnetic resonance imaging (fetMRI) has been used to predict survival of fetuses with isolated congenital diaphragmatic hernia (CDH). So far, the accuracy and precision of fetMRI for volumetry of either the normal or hypoplastic developing lung has not been formally studied.
Reconfigurable frequency using electromagnetic band gap structures for single band and wideband

Electromagnetic bandgap (EBG) structures have become a favorable field of research within the microwaves, photonics, and antenna design. The unusual properties of this structure such as frequency bandgap [1], in phase reflector arrays [2] and high impedances surface [3] made this structure unique. Several reports have been published to show the ability of EBG structures to improve the performance of the conventional devices when they are integrated together [4]. Some of them are improving radiation pattern of antenna [5], suppressing surface waves for planar antenna design [6], reducing mutual coupling [7] and steering the beam of antenna's radiation pattern for array design [8]. The resonance frequency of EBG structures depend on the equivalent LC network of the structure. To obtain the specific resonance frequency, many researchers proposed different kind of structures which is normally obtained by modifying the shape of EBG patches itself [9]. The operating frequency is tuned by varying the value of total capacitance, C. Several researchers work on tuning the operating frequency of the EBG structures by introducing tuning element, which mean to vary the inductance value. But, that kind of design do not provide much degree of freedom on selecting which frequency band to operate and which types of bandwidth it prefer to be whether single narrowband frequency, multiband frequency or wideband frequency.
School Recess: Implications for Education and Development

In this article the empirical research on the role of school recess is reviewed. Recess is first defined, and then the effects of child-level variables (e.g., gender, age, and temperament) and school-level variables (e.g., recess timing and duration) on children’s recess behavior are reviewed. The implications of recess are discussed in terms of impact on classroom behavior and on measures of social and cognitive competence. It is concluded that recess has important educational and developmental implications. Further research in this area is urgently needed, and some promising areas of inquiry are suggested.
Promoting habit formation

Abstract Habits are automatic behavioural responses to environmental cues, thought to develop through repetition of behaviour in consistent contexts. When habit is strong, deliberate intentions have been shown to have a reduced influence on behaviour. The habit concept may provide a mechanism for establishing new behaviours, and so healthy habit formation is a desired outcome for many interventions. Habits also however represent a potential challenge for changing ingrained unhealthy behaviours, which may be resistant to motivational shifts. This review aims to provide intervention developers with tools to help establish target behaviours as habits, based on theoretical and empirical insights. We discuss evidence-based techniques for forming new healthy habits and breaking existing unhealthy habits. To promote habit formation we focus on strategies to initiate a new behaviour, support context-dependent repetition of this behaviour, and facilitate the development of automaticity. We discuss techniques for disrupting existing unwanted habits, which relate to restructuring the personal environment and enabling alternative responses to situational cues.
Novel prostaglandin receptor modulators – Part II: EP receptor modulators; a patent review (2002 – 2012)

Introduction: Prostaglandins and their G-protein–coupled receptors play numerous physiological and pathophysiological roles, especially in inflammation and its resolution. The variety of effects mediated by prostanoids makes prostanoid receptors valuable drug targets and the research on prostaglandin receptor modulators is intensive. The physiological and pathophysiological effects of prostaglandin E2 are especially complex and numerous. The four subtypes of EP receptor have gained a lot of industrial and academic interest, in particular EP2 and EP4 for various indications. Areas covered: Evaluation of the patent activity over the last decade (2002 – 2012) illustrates several potent compounds targeting the distinct prostaglandin E2 receptors. Many novel methods for the use of EP receptor modulators have been developed, in addition to the classical indications for agents modulating the arachidonic acid cascade such as pain and inflammation. Expert opinion: Several EP targeting agents with good potency and selectivity have been developed but their pharmacological use and utility has not yet been satisfactorily investigated. More research is necessary, and clinical use of these agents might therefore take some more time.
Belief in the Effic acy of Psychotherapy (BEP): Psychometric Scale Development and Examination of Theor etical Correlates

This study develops a psychometric scale measuring the extent to which an individual expects psychotherapy to be effective: The Belief in the Efficacy of Psychotherapy (BEP). Based in the research that describes expectations for therapy as process expectations or outcome expectations, the BEP scale is developed to measure outcome expectations for therapy exclusively (i.e., is psychotherapy helpful? ). Current expectancy measures vastly underrepresent outcome expectations in particular, and BEP will be the first to focus solely on outcome expectations. Additionally, the proposed BEP scale measures the general cultural belief system (i.e., non-patients) and their beliefs about psychotherapy and therapists specifically, rather than other forms of mental health services. The present study develops the scale (BEP), tests its psychometric properties, and examines how BEP covaries with personality characteristics such as the “Big Five,” Optimism, and Psychological Mindedness (PM), and Treatment Rejection (RXR).
Identification of annexin A13 as a regulator of chemotherapy resistance using random homozygous gene perturbation.

OBJECTIVE To utilize a powerful new technology for target discovery, Random Homozygous Gene Perturbation (RHGP), and to identify novel targets that cause tumor cells to become chemoresistant. STUDY DESIGN RHGP was used to identify and validate genetic changes that cause chemoresistance of tumor cells to Rapamycin. RESULTS A series of targets was identified that allowed tumor cells to survive treatment with Rapamycin. We validated these targets and focused on Annexin A13, a target where decreased expression caused tumor cell insensitivity to Rapamycin. Ectopic overexpression of Annexin A13 was likewise sufficient to sensitize malignant breast cancer cells to treatment with Rapamycin. CONCLUSION These findings expand our knowledge of mechanisms that allow tumor cell drug resistance and demonstrate the power of RHGP to identify novel targets and mechanisms.
Trajectory control of a bipedal walking robot with inertial disc

Abstract In this paper we exploit some interesting properties of a class of 2D bipedal robots which have an inertial disc. One of this properties is the ability to control every position and speed except for the disc position. The proposed control is designed in two hierarchic levels. The first will drive the robot geometry, while the second will control the speed and also the angular momentum. The exponential stability of this approach is proved around some neighborhood of the nominal trajectory defining the geometry of the step. The disc position is unimportant ant it is not governed by the proposed control law. The geometry of the walking gait is effectively controlled, but the synchronization of the walking gait with time is much less important The proposed control only takes action to correct the essential aspects of the walking gait. Computational simulations are presented for different conditions, serving as an empirical test for the neighborhood of attraction.
A Quantitative Analysis of Growth and Size Regulation in Manduca sexta: The Physiological Basis of Variation in Size and Age at Metamorphosis

Body size and development time are important life history traits because they are often highly correlated with fitness. Although the developmental mechanisms that control growth have been well studied, the mechanisms that control how a species-characteristic body size is achieved remain poorly understood. In insects adult body size is determined by the number of larval molts, the size increment at each molt, and the mechanism that determines during which instar larval growth will stop. Adult insects do not grow, so the size at which a larva stops growing determines adult body size. Here we develop a quantitative understanding of the kinetics of growth throughout larval life of Manduca sexta, under different conditions of nutrition and temperature, and for genetic strains with different adult body sizes. We show that the generally accepted view that the size increment at each molt is constant (Dyar’s Rule) is systematically violated: there is actually a progressive increase in the size increment from instar to instar that is independent of temperature. In addition, the mass-specific growth rate declines throughout the growth phase in a temperature-dependent manner. We show that growth within an instar follows a truncated Gompertz trajectory. The critical weight, which determines when in an instar a molt will occur, and the threshold size, which determines which instar is the last, are different in genetic strains with different adult body sizes. Under nutrient and temperature stress Manduca has a variable number of larval instars and we show that this is due to the fact that more molts at smaller increments are taken before threshold size is reached. We test whether the new insight into the kinetics of growth and size determination are sufficient to explain body size and development time through a mathematical model that incorporates our quantitative findings.
Quantifying the Quality of Mediation Agreements

AbstractFor workplace mediation programs, success is most oftenmeasured by assessing the agreement rate. However, it isunlikely that all signed agreements are of equal quality.Starting with the principle that the ‘‘success’’ of a media-tion program cannot be limited to its agreement rate, wedesigned a study to assess the quality of mediation agree-ments. This article uses a questionnaire based on a ﬁve-dimension framework (mediator’s usefulness, proceduraljustice, satisfaction with agreement, conﬁdence in agree-ment, and reconciliation between parties) to conducta cluster analysis of a sample of agreements from a gov-ernmental mediation program. Three types of agreementare identiﬁed: disappointing, satisfactory, and value-addedagreements. The study’s theoretical contributions as wellas its practical implications for mediators and mediationprograms are discussed. This study received ﬁnancial support from the Fonds que ´be ´cois de la recherche sur la societe et la culture,under the Programme d’e´tablissement de nouveaux professeurs—chercheur (Quebec Social Sciences and Human-ities Research Council (ref. #88392). The data were collected in collaboration with the Commission des nor-mes du travail du Que´bec. The author would like to thank Diane Beaudoin, Jean-Marc Gauthier, DanielLangevin, Danielle Laliberte´, Guy Laroche, and Jocelyn Girard of the Commission des normes du travail duQue´bec for their contribution to data collection. The author would also like to thank the reviewers for theirhelpful comments on earlier draft of this article.
Trends in incidence of pneumococcal disease before introduction of conjugate vaccine: South West England, 1996–2005

SUMMARY Introduction of pneumococcal conjugate and polysaccharide vaccines into the United Kingdom's routine immunization programmes is expected to change the epidemiology of invasive pneumococcal disease (IPD). We have documented the epidemiology of IPD in an English region (South West) with high-quality surveillance data before these programmes were established. We analysed data on isolates of Streptococcus pneumoniae from blood and CSF between 1996 and 2005 from microbiology laboratories in the South West that were reported and/or referred for serotyping to the Health Protection Agency Centre for Infections. The mean annual incidence of IPD increased from 11·2/100 000 in 1996 to 13·6/100 000 in 2005 (P<0·04). After adjusting for annual blood-culture sampling rates in hospitals serving the same catchment populations, an increase in annual incidence of IPD was no longer observed (P=1·0). Variation in overall incidence between laboratories could also be explained by variation in blood culture rates. The proportion of disease caused by serotypes 6B, 9V and 14 decreased significantly (P=0·001, P=0·007, and P=0·027 respectively) whereas that caused by serotype 4, 7F and 1 increased (P=0·001, P=0·003, and P<0·001 respectively) between 2000 and 2005. The level of penicillin non-susceptibility and resistance to erythromycin remained stable (2% and 12% respectively). This study provides an important baseline to assess the impact of changing vaccination programmes on the epidemiology of IPD, thus informing future use of pneumococcal vaccines.
Multiplexed optical pathogen detection with lab‐on‐a‐chip devices

Infectious diseases are still a main cause of human morbidity and mortality. Advanced diagnostics is considered to be a key driver to improve the respective therapeutic outcome. The main factors influencing the impact of diagnostics include: assay speed, availability, information content, in‐vitro diagnostics and cost, for which molecular assays are providing the most promising opportunities. Miniaturisation and integration of assay steps into lab‐on‐a‐chip devices has been described as an appropriate way to speed up assay time and make assays available onsite at competitive costs. As meaningful assays for infectious diseases need to include a whole range of clinical relevant information about the pathogen, multiplexed functionality is often required for which optical transduction is particularly well suited. The aim of this review is to assess existing developments in this field and to give an outlook on future requirements and solutions. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Meta‐regression with partial information on summary trial or patient characteristics

We present a model for meta‐regression in the presence of missing information on some of the study level covariates, obtaining inferences using Bayesian methods. In practice, when confronted with missing covariate data in a meta‐regression, it is common to carry out a complete case or available case analysis. We propose to use the full observed data, modelling the joint density as a factorization of a meta‐regression model and a conditional factorization of the density for the covariates. With the inclusion of several covariates, inter‐relations between these covariates are modelled. Under this joint likelihood‐based approach, it is shown that the lesser assumption of the covariates being Missing At Random is imposed, instead of the more usual Missing Completely At Random (MCAR) assumption. The model is easily programmable in WinBUGS, and we examine, through the analysis of two real data sets, sensitivity and robustness of results to the MCAR assumption. Copyright © 2010 John Wiley & Sons, Ltd.
Behavioral synchronization of human and humanoid robot

This paper explores interaction design and real time implementation of behavioral synchronization of Human and Humanoid robot. Human postures are captured into a 3D skeleton using Kinect sensor. Single 3D coordinates of joints can be derived from the skeleton. For the behavioral synchronization primitive humanoid robot with 16 servo motors are used. Human's joint coordinates are extracted from the standing posture. Using mechanism suggested in this paper, the joints information converted and mapped to the humanoid robot. The overall architecture was designed and implemented in expandable way. This gives opportunity to control humanoid robot locally as well as remotely. Suggested behavioral synchronization method from this work is implemented and validated. Time delay issues are also considered as a significant topic in instance implementation. Behavior synchronization of human and robot have totally 400 millisecond time delays, where 50% is related to humanoid's internal latency. Additionally suggested architecture provides another mode, where user can use alternative controllers.
Lines on feeling: foregrounding, aesthetics and meaning

Research in experimental aesthetics suggests a relation between complexity and novelty on the one hand and hedonic value on the other (Berlyne, 1980). Defining foregrounding as deviation from daily language, the concept seems closely associated with novelty, and therefore a relation may be expected between the degree of deviation and readers' aesthetic appreciation. Also, deviation is assumed to be the key to understanding style, and leads readers in their interpretation of a text. These hypotheses are confirmed by recent evidence (Miall and Kuiken, 1994; Hakemulder, 2004; Zyngier, van Peer and Hakemulder, in press). The present study aims to enhance control over potential factors, refining the assessment of readers' background variables, and excluding interference of text factors other than deviation. For this purpose six versions of one poetry line were written, with an ascending degree of foregrounding from the first to the sixth line. More than 300 participants were assigned randomly to a total of 13 groups. Some read one of the six lines of a poem. To other groups, adjacent lines were presented hierarchically or in a large difference in degree of foregrounding (four lines apart in the hierarchy). Participants evaluated the single line they had been assigned to, or compared their two lines on a number of items measuring aesthetic appreciation, evaluation of aesthetic structure, and perceived cognitive, emotive, social and attitudinal impact. In addition, they completed a questionnaire on reading habits. It was hypothesized that higher degrees of deviation would lead to higher scores on these measures. Part of the predictions was confirmed by the results.
Attachment and callous-unemotional traits in children with early-onset conduct problems.

BACKGROUND Antisocial children with callous-unemotional (CU) traits appear to be disconnected from other people's emotions; although little is known about their experience of the parent-child emotional bond. This study examined parent-child attachment relationships and levels of CU traits in conduct-problem children. METHOD Attachment classifications in boys (M = 6.31 years) with disruptive behaviour disorders were assessed using the Manchester Child Attachment Story Task. Multiple informants rated children's CU traits. RESULTS Independent of severity of conduct problems, high levels of CU traits were associated with more insecure attachment; specifically, disorganised attachment representations; however, CU traits were not associated with avoidant representations. CONCLUSIONS Among conduct-problem children, those higher on CU traits appear to be at increased risk of experiencing disruptions in parent-child attachment relationships; attachment may be an important area for treatment and prevention efforts for CU traits in young children.