Miracle-dz/UniFAR-FTUs huggingface dataset:
Intelligent vehicle monitoring system using wireless communication

The use of mobile phones while driving is one of the most dangerous and widely seen causes of fatal road accidents. The objective of the paper is to develop a device to find people who use mobile phones while driving and evade from stringent laws enforced by the government easily. This novel and ingenious technique facilitates the government to take adequate action against those who are violating these laws. To meet the requirements of an intelligent vehicle monitoring system, this architecture integrates Global Position System (GPS), Global System for Mobile communications (GSM) and a Microcontroller in the whole. This device is used to prevent texting and calling of mobile phones while driving vehicles. If the driver is using the phone while the vehicle is in motion, it triggers a signal which notifies the cops with the vehicle's number plate and the location with the help of GPS system. It receives the mobile signal and detects the presence of mobile. This signal eventually triggers the microcontroller with a glowing LED. Due to the voltage fluctuation, the message is sent to the cops using GSM communication.
Mining proteomic data for biomedical research

The popularity of proteomics in biomedical research has grown with the development of advanced measurement technologies. This has enabled high‐throughput protein expression profiling, modification‐specific proteomics, and global protein–protein interaction maps. Although proteomics has great potential in providing deeper understanding of the role of individual proteins and protein networks in disease and in unveiling the underlying disease mechanisms, challenges arise in transforming the large‐scale experimental data into biomedical knowledge for clinical practice and drug development. In particular, sophisticated computational tools are required to interpret the high‐dimensional proteomic datasets that typically reflect not only biological information, but also technical biases and limitations. This review gives an overview of the role of data mining in biomedical applications of proteomics, with a focus on data from mass spectrometry‐based expression profiling studies. © 2011 Wiley Periodicals, Inc.
Optimal Transcoding and Caching for Adaptive Streaming in Media Cloud: an Analytical Approach

Nowadays, large-scale video distribution feeds a significant fraction of the global Internet traffic. However, existing content delivery networks may not be cost efficient enough to distribute adaptive video streaming, mainly due to the lack of orchestration on storage, computing, and bandwidth resources. In this paper, we leverage Media Cloud to deliver on-demand adaptive video streaming services, where those resources can be dynamically scheduled in an on-demand fashion. Our objective is to minimize the total operational cost by optimally orchestrating multiple resources. Specifically, we formulate an optimization problem, by examining a three-way tradeoff between the caching, transcoding, and bandwidth costs, at each edge server. Then, we adopt a two-step approach to analytically derive the closed-form solution of the optimal transcoding configuration and caching space allocation, respectively, for every edge server. Finally, we verify our solution throughout extensive simulations. The results indicate that our approach achieves significant cost savings compared with the existing methods used in content delivery networks. In addition, we also find the optimal strategy and its benefits can be affected by a list of system parameters, including the unit cost of different resources, the hop distance to the origin server, the Zipf parameter of users' request patterns, and the settings of different bitrate versions for one segment.
Histologic Artifacts in Abdominal, Vaginal, Laparoscopic, and Robotic Hysterectomy Specimens: A Blinded, Retrospective Review

Total laparoscopic hysterectomy (LH) is a minimally invasive technique, which results in comparable morbidity and better cosmesis compared with total abdominal hysterectomy. The literature is discrepant as to whether it is associated with a higher incidence of positive peritoneal cytology compared with total abdominal hysterectomy and recently, associated artifacts, including vascular pseudoinvasion (VPI), have been described. A retrospective histopathologic review of 266 hysterectomy specimens from 2 centers was performed. The observers, blinded to the surgical technique, assessed for the presence of artifactual changes including disruption of the endometrial lining, nuclear crush artifact, VPI, endomyometrial cleft artifact with or without epithelial displacement, inflammatory debris within vessels, serosal carryover, and intratubal contaminants. In addition, the rates of positive peritoneal washings over a 5-year period, and the use of immunohistochemistry (IHC) to aid in cell typing over a 3-year period, were compared between hysterectomies in which a uterine manipulator (UM) device had and had not (nonmanipulated hysterectomies) been used. The hysterectomies were performed for malignant (n=160) and benign (n=102) uterine disease or for ovarian or cervical disease (n=4), and included total abdominal (n=108), vaginal (n=17), laparoscopy-assisted vaginal (n=24), laparoscopy converted to laparotomy (n=10), nonrobotic laparoscopic (n=51), and robot-assisted laparoscopic (n=56) hysterectomies. One hundred and two (38%) of these hysterectomies involved the use of a UM. Artifactual changes of disruption of the endometrial lining, endomyometrial clefts, intratubal contaminants, nuclear crush artifact, intravascular inflammatory debris, and VPI were significantly more common with LH and with the use of a UM, independent of whether the endometrial pathology was benign or malignant. IHC to aid in endometrial cancer subtyping was more likely to be used in manipulated hysterectomies (P=0.0166). Furthermore, peritoneal washings were significantly more likely to be positive in hysterectomies in which a UM had been used (P=0.0061). Histologic artifacts are significantly more common in LH and specifically in hysterectomies in which a UM is used. Such artifacts impair the pathologists' interpretation of cell type requiring an increased use of IHC, and displaced epithelial fragments present within vessels or artifactual clefts may result in the misinterpretation of prognostic and staging parameters. Furthermore, there is a significantly higher rate of positive peritoneal cytology in cases that are subjected to uterine manipulation, suggesting dissemination of malignant cells into the abdominal cavity. The clinical significance of this finding needs to be determined.
Boceprevir and telaprevir for the treatment of chronic hepatitis C: safety management in clinical practice

Effective management of adverse events (AEs) is important to prevent treatment discontinuation and optimize hepatitis C virus infection eradication rates. The addition of direct‐acting antiviral agents, telaprevir (TVR) or boceprevir to pegylated interferon (PEG‐IFN) and ribavirin (RBV) represents a new era of therapy associated with an improvement in treatment response rates and an impairment of the safety profile compared to PEG‐IFN/RBV. An increase in the frequency and severity of anaemia was reported in clinical trials for both drugs, and skin disorders including rash and pruritus occurred more frequently with the TVR‐based regimen. These AEs are generally manageable and do not lead to early discontinuation. The management of anaemia has not been clearly established, and the impact of RBV dose reductions and erythropoietin alpha use on treatment efficacy and safety must be clarified. The management of rashes, which were mild and moderate in more than 90% of the cases, is well planned, does not require TVR discontinuation and can be treated using emollients and topical corticosteroids. However, approximately 5% of rashes were severe, and a few cases were classified as severe cutaneous adverse reactions leading to treatment discontinuation.
Long-Lasting Alterations in Membrane Properties, K+ Currents, and Glutamatergic Synaptic Currents of Nucleus Accumbens Medium Spiny Neurons in a Rat Model of Alcohol Dependence

Chronic alcohol exposure causes marked changes in reinforcement mechanisms and motivational state that are thought to contribute to the development of cravings and relapse during protracted withdrawal. The nucleus accumbens (NAcc) is a key structure of the mesolimbic dopaminergic reward system. Although the NAcc plays an important role in mediating alcohol-seeking behaviors, little is known about the molecular mechanisms underlying alcohol-induced neuroadaptive changes in NAcc function. The aim of this study was to investigate the effects of chronic intermittent ethanol (CIE) treatment, a rat model of alcohol withdrawal and dependence, on intrinsic electrical membrane properties and glutamatergic synaptic transmission of medium spiny neurons (MSNs) in the NAcc core during protracted withdrawal. We show that CIE treatment followed by prolonged withdrawal increased the inward rectification of MSNs observed at hyperpolarized potentials. In addition, MSNs from CIE-treated animals displayed a lower input resistance, faster action potentials (APs), and larger fast afterhyperpolarizations (fAHPs) than MSNs from vehicle-treated animals, all suggestive of increases in K+-channel conductances. Significant increases in the Cs+-sensitive inwardly rectifying K+-current accounted for the increased input resistance, while increases in the A-type K+-current accounted for the faster APs and increased fAHPs in MSNs from CIE rats. We also show that the amplitude and the conductance of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediated mEPSCs were enhanced in CIE-treated animals due to an increase in a small fraction of functional postsynaptic GluA2-lacking AMPARs. These long-lasting modifications of excitability and excitatory synaptic receptor function of MSNs in the NAcc core could play a critical role in the neuroadaptive changes underlying alcohol withdrawal and dependence.
The Limits of Equality: Insights from the Israeli Kibbutz

What limits the capacity of society to redistribute and provide insurance? What determines the structure of compensation in organizations striving for income equality? This paper addresses these questions by investigating the economic and sociological forces underlying the persistence of the Israeli kibbutzim, communities based on the principle of income equality. To do this, I exploit newly-assembled data on kibbutzim, and a financial crisis in the late-1980s that affected them differentially. The main findings are that: (1) productive individuals are the most likely to exit, and a kibbutz’s wealth serves as a lock-in device that increases the value of staying; (2) higher wealth reduces exit and supports a high degree of income equality; (3) ideology contributes to income equality. Using a simple model, I show that these findings are consistent with a view of the kibbutz as providing optimal insurance without commitment to stay, namely when participation is at-will. More generally, these findings contribute to an understanding of how mobility limits redistribution, and to an understanding of the determinants of the sharing rule in other types of organizations, such as professional partnerships, cooperatives and labor-managed firms.
On the Cellular and Molecular Mechanisms of Drug-Induced Gingival Overgrowth

Introduction: Gingival overgrowth has been linked to multiple factors such as adverse drug effects, inflammation, neoplastic processes, and hereditary gingival fibromatosis. Drug-induced gingival overgrowth is a well-established adverse event. In early stages, this gingival enlargement is usually located in the area of the interdental papilla. Histologically, there is an increase in the different components of the extracellular matrix. Objective: The aim of this manuscript is to describe and analyze the different cellular and molecular agents involved in the pathogenesis of Drug-induced gingival overgrowth. Method: A literature search of the MEDLINE/PubMed database was conducted to identify the mechanisms involved in the process of drug-induced gingival overgrowth, with the assistance of a research librarian. We present several causal hypotheses and discuss the advances in the understanding of the mechanisms that trigger this gingival alteration. Results: In vitro studies have revealed phenotypic cellular changes in keratinocytes and fibroblasts and an increase of the extracellular matrix with collagen and glycosaminoglycans. Drug-induced gingival overgrowth confirms the key role of collagenase and integrins, membrane receptors present in the fibroblasts, due to their involvement in the catabolism of collagen. The three drug categories implicated: calcineuron inhibitors (immunosuppressant drugs), calcium channel blocking agents and anticonvulsant drugs appear to present a multifactorial pathogenesis with a common molecular action: the blockage of the cell membrane in the Ca2+/Na+ ion flow. The alteration of the uptake of cellular folic acid, which depends on the regulated channels of active cationic transport and on passive diffusion, results in a dysfunctional degradation of the connective tissue. Certain intermediate molecules such as cytokines and prostaglandins play a role in this pathological mechanism. The concomitant inflammatory factor encourages the appearance of fibroblasts, which leads to gingival fibrosis. Susceptibility to gingival overgrowth in some fibroblast subpopulations is due to phenotypic variability and genetic polymorphism, as shown by the increase in the synthesis of molecules related to the response of the gingival tissue to inducing drugs. The authors present a diagram depicting various mechanisms involved in the pathogenesis of drug-induced gingival overgrowth. Conclusion: Individual predisposition, tissue inflammation, and molecular changes in response to the inducing drug favor the clinical manifestation of gingival overgrowth.
The Complex Role of Neutrophils in Tumor Angiogenesis and Metastasis

Chronic inflammation fosters cancer development and progression and also modulates tumor responses to anticancer therapies. Neutrophils are key effector cells in innate immunity and are known to play a critical role in various inflammatory disorders. However, the functions of neutrophils in cancer pathogenesis have been largely neglected until recently and still remain poorly characterized compared with other immune cells in the tumor microenvironment. We highlight recent findings on the mechanisms by which tumor cells, in cooperation with tumor-associated stromal cells, induce expansion, recruitment, and polarization of neutrophils. We also review the multifaceted roles that neutrophils play in different aspects of cancer development and progression, with an emphasis on tumor angiogenesis and metastasis. Cancer Immunol Res; 4(2); 83–91. ©2016 AACR.
Watching nuclei move

Moving nuclei to specific intracellular locations is central to many cell and developmental processes. However, the molecular mechanisms of nuclear migration are poorly understood. We took advantage of the ability to film nuclear migration events in Caenorhabditis elegans embryos to gain insights into the mechanisms of nuclear migration. Mutations in unc-83 blocked the initiation of nuclear migration. UNC-83 recruits kinesin-1 and dynein to the nuclear envelope. Live imaging of mutants showed that kinein-1 provides the major force to move nuclei. Dynein is responsible to move nuclei backwards or to mediate nuclear rolling to by pass cellular roadblocks that impede efficient migration. Live imaging was also used to analyze the microtubule network, which is highly polarized and dynamic. This detailed mechanism of nuclear migration may be applicable to nuclear migration in other systems and for the movement of other large cellular cargo.
Notice of RetractionCloning of IAP Gene in Culex quinquefasciatus and Its Molecular Evolution Analysis

Inhibitor of apoptosis proteins (IAPs) constitute a family of proteins that contain one to three baculovirus IAP repeats(BIR). This IAP family ensure cell viability through binding to caspases with the BIR domain and regulating their activity in a ubiquitin-dependent manner. While IAPs are regulated by their antagonists. To investigate the regulation pathway of IAP, we have cloned and sequenced the Cqiap gene of Culex quinquefasciatus from China by RT PCR. It's 1230bp in length. The putative protein of Cqiap contains two BIR domains and one RING finger domain. Cqiap is highly identity with iap of the published Culex quinquefasciatus (GENE ID: 6032833, 99.6%). Multiple sequence alignment and phylogenetic tree analysis show that animal IAPs were classified into two major groups. As to the species we list in this paper , one group is from invertebrate IAPs with two BIR domains, the other group contains invertebrate and vertebrate IAPs with three BIR domains. The reported IAP of Culex quinquefasciatus from China falls into the group of IAPs with 2 BIR domains.
Capacity Optimization and Modelling of frequency selective WLAN indoor MIMO Channels based on measured data

: Motivated by channel measurements in different indoor locations we will show that the WLAN indoor MIMO channel is characterized by few dominant transmission paths mainly corresponding to the LOS path and some strong reﬂections. In the contrary to the common statistical ﬂat Rayleigh fading channel model we will explain that the WLAN channel is widely deterministic and frequency selective. Furthermore we calculate the channel capacity from the measured data and we show its dependence on the geometrical arrangement of the transmit and receive antennas and the characteristics of the location. Here strong variations are observed and therefore we present some promising approaches that could be valid to reduce these capacity variations and enhance the overall capacity.
Estimation and removal of clock skew from delay measures

Packet delay traces are important sources of measurements for analyzing end-to-end performance of computer networks. Due to the lack of tight synchronization between the clocks of end systems, these measurements can be quite inaccurate. Therefore, detection, estimation and removal of clock skew from delay traces is a critical operation to obtain precise measurements of network latencies. In this paper, we propose two new techniques to detect, estimate and remove the clock skew in delay traces. The first technique, named average technique, derives the clock skew estimate by calculating the average of the difference between consecutive packets' delay. The second technique, named direct skew removal technique, proceeds by iteratively evaluating a set of possible skew values until the best value is reached. Compared with existing techniques such as linear programming and convex-hull, the average technique reduces the complexity of the skew estimation operation. The direct skew removal is more accurate and allows us to obtain delay after skew removal with the same precision as the original traces. Clock skew is also present in online delay measurements that are used by real-time endpoints such as audio and video terminals, to determine the buffering delay of received packets and to synchronize streams from different sources. The problem is more obvious when communication sessions last for a long time. Contrary to the offline skew removal, little work has been done on the online skew removal problem. We propose two simple algorithms to remove the clock skew from online delay measurements. The first algorithm, named the sliding window algorithm, tracks the skew by continually evaluating the variation of the minimum measured delay. The second algorithm, named the combined algorithm, is a mixed approach of the sliding window and the convex-hull algorithm proposed elsewhere.
NVGaze: An Anatomically-Informed Dataset for Low-Latency, Near-Eye Gaze Estimation

Quality, diversity, and size of training data are critical factors for learning-based gaze estimators. We create two datasets satisfying these criteria for near-eye gaze estimation under infrared illumination: a synthetic dataset using anatomically-informed eye and face models with variations in face shape, gaze direction, pupil and iris, skin tone, and external conditions (2M images at 1280x960), and a real-world dataset collected with 35 subjects (2.5M images at 640x480). Using these datasets we train neural networks performing with sub-millisecond latency. Our gaze estimation network achieves 2.06(±0.44)° of accuracy across a wide 30°×40° field of view on real subjects excluded from training and 0.5° best-case accuracy (across the same FOV) when explicitly trained for one real subject. We also train a pupil localization network which achieves higher robustness than previous methods.
WLC36-1: On the Optimality of Beamforming in MIMO Fading Ad-Hoc Networks

We consider MIMO fading ad-hoc networks with Rayleigh co-channel interference where, L transmitter/receiver pairs communicate independent information over the network, simultaneously. We assume perfect channel state information (CSI) of the desired receiver is available at each transmitter and receivers perform single-user detection. In this paper, we study the asymptotic capacity of the considered system, in the limit of a large number of pairs, i.e., L rarr infin. Through asymptotic large- system analysis, we show that performing beamforming by all users approaches the optimum signaling in the sense of achieving the system capacity.
Implementation of Strassen's Algorithm for Matrix Multiplication

In this paper we report on the development of an efficient and portable implementation of Strassen's matrix mulitplication algorithm. Our implementation is designed to be used in place of DGEMM, the Level 3 BLAS matrix mulitplication routine. Efficient performance will be obtained for all matrix sizes and shapes and the additional memory needed fro temporary variables has been minimized. Replacing DGEMM with our routine should provide a significant performance gain for large matrices while providing the same performance for small matrices. We measure performance of our code on the IBM RS/6000, CRAY YMP C90, and CRAY T3D single processor, and offer comparisons to other codes. Our performance data reconfirms that Strassen's algorithm is practical for realistic size matrices. The usefulness of our implementation is demonstrated by replacing DGEMM with our routine in a large application code.
New Complete Complementary Codes for Peak-to-Mean Power Control in Multi-Carrier CDMA

Owing to the zero non-trivial aperiodic correlation sum properties, complete complementary codes (CCC) have been applied to asynchronous multi-carrier code-division multiple-access (MC-CDMA) communications in order to provide zero interference performance. When each complementary code is arranged to be a matrix, the peak-to-mean envelope power ratio (PMEPR) of the CCC-MC-CDMA system is determined by the column sequences of the complementary matrices. The existing CCC have the column sequence PMEPR of M, where M denotes the number of subcarriers in a CCC-MC-CDMA system. In practice, M is generally large and a PMEPR approaching this value is unacceptable. To solve this problem, a new class of CCC using generalized Boolean functions and with a column sequence PMEPR of at most 2 is proposed in this paper.
Beneficial and detrimental effects of human endogenous retroviruses

In this mini review, we aim to evaluate the structure and function of Human Endogenous Retroviruses (HERVs) with respect to the benefit they may have for humans or the damage they may cause. Emphasis is laid on their putative roles, if any, in pregnancy, in gene regulation and in cancer. As a basis for this discussion it will first be necessary to briefly describe the structure and function of retroelements, including HERVs, before addressing their positive or negative effects at the cellular and organismal level. Finally, we will give an outlook in which we will attempt to define priorities for future research.