Miracle-dz/UniFAR-FTUs huggingface dataset:
On Bernstein-Szego¨ orthogonal polynomials on several intervals

Let $l \in \mathbb{N}$, $a_1 < a_2 < \cdots < a_{2l} $, $E_l = \bigcup _{k = 1}^l [a_{2k - 1} ,a_{2k} ]$, $H(x) = \prod _{k = 1}^{2l} (x - a_k )$ and let $\rho _\nu (x) = c\prod _{k = 1}^{\nu ^ * } (x - w_k )^{\nu _k } $ be a real polynomial with $w_k \notin \operatorname{int} (E_l )$ for $k = 1, \cdots ,\nu ^ * $ and $\nu _k = 1$ if $w_k $ is a boundary point of $E_l $. For given $\rho _\nu $ and $\varepsilon = (\varepsilon _1 , \cdots ,\varepsilon _{\nu ^ * } )$, $\varepsilon _k \in \{ - 1,1\} $, the following linear functional on $\mathbb{P}$, $\mathbb{P}$ denoting the space of real polynomials, is defined: \[ \begin{gathered} \Psi _{H,\rho _\nu ,\varepsilon } (p) = \int_{E_l } {p(x)} \frac{{\sqrt { - H(x)} }}{{\rho _\nu (x)}}\operatorname{sgn} \left( { - \mathop \prod \limits_{k = 1}^l \left( {x - a_{2k - 1} } \right)} \right)dx \hfill \\ \qquad \qquad \qquad + \sum_{k = 1}^{\nu ^ * } {\left( {1 - \varepsilon _k } \right)} \sum\limits_{j = 1}^{\nu _k } {\mu _{j,k} } p^{(j - 1)} \left( {w_k } \right) \.
Multistate reliability models

In this paper an axiomatic development of multistate systems is presented. Three types of coherence based on the strength of the relevancy axiom are studied. The strongest of these has been investigated previously by El-Neweihi, Proschan, and Sethuraman [3]. One of the weaker types of coherence permits wider applicability to real life situations without sacrificing any of the mathematical results obtained by El-Neweihi, Proschan, and Sethuraman. The concept of system performance is formalized through expected utility and the effect of component improvement on system performance is studied using a generalization of Birnbaum's reliability importance.
Multi-Omics Integration to Reveal the Mechanism of Sericin Inhibiting LPS-Induced Inflammation

Sericin is a natural protein with high application potential, but the research on its efficacy is very limited. In this study, the anti-inflammatory mechanism of sericin protein was investigated. Firstly, the protein composition of sericin extracts was determined by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). This was then combined with Enzyme-linked Immunosorbent Assay (ELISA) and Quantitative Real-time PCR (qRT-PCR), and it was confirmed that the anti-inflammation ability of sericin was positively correlated with the purity of sericin 1 protein. Finally, RNA-seq was performed to quantify the inhibitory capacity of sericin sample SS2 in LPS-stimulated macrophages. The gene functional annotation showed that SS2 suppressed almost all PRRs signaling pathways activated by lipopolysaccharides (LPS), such as the Toll-like receptors (TLRs) and NOD-like receptors (NLRs) signaling pathways. The expression level of adaptor gene MyD88 and receptor gene NOD1 was significantly down-regulated after SS2 treatment. SS2 also reduced the phosphorylation levels of NF-κB P65, P38, and JNK, thereby reducing the expressions of IL-1β, IL-6, INOS, and other inflammatory cytokines. It was confirmed that sericin inhibited LPS-induced inflammation through MyD88/NF-κB pathway. This finding provides necessary theoretical support for sericin development and application.
An Ultraviolet and Near-Infrared View of NGC 4214: A Starbursting Core Embedded in a Low Surface Brightness Disk

During the Astro-2 Spacelab mission in 1995 March, the Ultraviolet Imaging Telescope (UIT) obtained far-UV (λ = 1500 Å) imagery of the nearby Sm/Im galaxy NGC 4214. The UIT images have a spatial resolution of ~3'' and a limiting surface brightness, μ1500 > 25 mag arcsec-2, permitting detailed investigation of the intensity and spatial distribution of the young, high-mass stellar component. These data provide the first far-UV imagery covering the full spatial extent of NGC 4214. Comparison with a corresponding I-band image reveals the presence of a starbursting core embedded in an extensive low surface brightness disk. In the far-UV (FUV), NGC 4214 is resolved into several components: a luminous, central knot; an inner region (r ≲ 2.5 kpc) with ~15 resolved sources embedded in bright, diffuse emission; and a population of fainter knots extending to the edge of the optically defined disk (r ≈ 5 kpc). The FUV light, which traces recent massive star formation, is observed to be more centrally concentrated than the I-band light, which traces the global stellar population. The FUV radial light profile is remarkably well represented by an R1/4 law, providing evidence that the centrally concentrated massive star formation in NGC 4214 is the result of an interaction, possibly a tidal encounter, with a dwarf companion(s). The brightest FUV source produces ~8% of the global FUV luminosity. This unresolved source, corresponding to the Wolf-Rayet knot described by Sargent & Filippenko, is located at the center of the FUV light distribution, giving NGC 4214 an active galactic nucleus-like morphology. Another strong source is present in the I band, located 19'' west, 10'' north of the central starburst knot, with no FUV counterpart. The I-band source may be the previously unrecognized nucleus of NGC 4214 or an evolved star cluster with an age greater than ~200 Myr. The global star formation rate derived from the total FUV flux is consistent with rates derived using data at other wavelengths and lends support to the scenario of roughly constant star formation during the last few hundred million years at a level significantly enhanced relative to the lifetime averaged star formation rate. The hybrid disk/starburst-irregular morphology evident in NGC 4214 emphasizes the danger of classifying galaxies based on their high surface brightness components at any particular wavelength.
Nanoengineering of NiO/MnO2/GO Ternary Composite for Use in High-Energy Storage Asymmetric Supercapacitor and Oxygen Evolution Reaction (OER)

Designing multifunctional nanomaterials for high performing electrochemical energy conversion and storage devices has been very challenging. A number of strategies have been reported to introduce multifunctionality in electrode/catalyst materials including alloying, doping, nanostructuring, compositing, etc. Here, we report the fabrication of a reduced graphene oxide (rGO)-based ternary composite NiO/MnO2/rGO (NMGO) having a range of active sites for enhanced electrochemical activity. The resultant sandwich structure consisted of a mesoporous backbone with NiO and MnO2 nanoparticles encapsulated between successive rGO layers, having different active sites in the form of Ni-, Mn-, and C-based species. The modified structure exhibited high conductivity owing to the presence of rGO, excellent charge storage capacity of 402 F·g−1 at a current density of 1 A·g−1, and stability with a capacitance retention of ~93% after 14,000 cycles. Moreover, the NMGO//MWCNT asymmetric device, assembled with NMGO and multi-wall carbon nanotubes (MWCNTs) as positive and negative electrodes, respectively, exhibited good energy density (28 Wh·kg−1), excellent power density (750 W·kg−1), and capacitance retention (88%) after 6000 cycles. To evaluate the multifunctionality of the modified nanostructure, the NMGO was also tested for its oxygen evolution reaction (OER) activity. The NMGO delivered a current density of 10 mA·cm−2 at the potential of 1.59 V versus RHE. These results clearly demonstrate high activity of the modified electrode with strong future potential.
Comparison of visual and acoustic surveys for the detection and dynamic management of North Atlantic right whales (Eubalaena glacialis) in Canada

The goal of this study was to develop a simulation to quantitatively compare acoustic and visual surveys and use it to inform current and future North Atlantic right whale (Eubalaena glacialis) risk mitigation. We expanded upon an established whale movement model, incorporating realistic right whale cues for visual and acoustic detection within dynamic management zones in the Gulf of Saint Lawrence, Canada. Survey transits by acoustic (Slocum gliders) and visual (aircraft, vessels, and Remotely Piloted Aircraft Systems) platforms were simulated using representative platform movements and detection functions. We used a Monte Carlo approach to estimate the probability of detecting a cue, in each zone, as a function of survey platform, number of right whales, and survey transits. Acoustic gliders detected right whale presence in every scenario. Single transits of a management zone by visual surveys were only able to reliably (>0.5 probability) detect right whales when more than 20 whales were present. Twenty or more transits were required to reliably detect a single right whale. Our results serve as a tool to be used by decision‐makers to inform optimal right whale monitoring strategies that consider the relative strengths of the various platforms.
Poly(ethylene oxide)-Based Copolymer-IL Composite Membranes for CO2 Separation

Poly(ethylene oxide) (PEO)-based copolymers are at the forefront of advanced membrane materials for selective CO2 separation. In this work, free-standing composite membranes were prepared by blending imidazolium-based ionic liquids (ILs) having different structural characteristics with a PEO-based copolymer previously developed by our group, targeting CO2 permeability improvement and effective CO2/gas separation. The effect of IL loading (30 and 40 wt%), alkyl chain length of the imidazolium cation (ethyl- and hexyl- chain) and the nature of the anion (TFSI-, C(CN)3-) on physicochemical and gas transport properties were studied. Among all composite membranes, PEO-based copolymer with 40 wt% IL3-[HMIM][TFSI] containing the longer alkyl chain of the cation and TFSI- as the anion exhibited the highest CO2 permeability of 46.1 Barrer and ideal CO2/H2 and CO2/CH4 selectivities of 5.6 and 39.0, respectively, at 30 °C. In addition, almost all composite membranes surpassed the upper bound limit for CO2/H2 separation. The above membrane showed the highest water vapor permeability value of 50,000 Barrer under both wet and dry conditions and a corresponding H2O/CO2 ideal selectivity value of 1080; values that are comparable with those reported for other highly water-selective PEO-based polymers. These results suggest the potential application of this membrane in hydrogen purification and dehydration of CO2 gas streams.
Novel Dual-Mode Dual-Band Bandpass Filter Using Microstrip Meander-Loop Resonators

A novel dual-mode dual-band bandpass filter using meander-loop resonators is proposed in this letter. Different meander-loop resonators are operated for respective passbands. Several finite attenuation poles in stopbands are realized to improve the selectivity of the proposed bandpass filter and isolation between the two passbands. Compact size, dual band and high selectivity characteristics are realized by this type of filter structure. The filter is evaluated by experiment and simulation with very good agreement.
Analysis and Design of a Non-Magnetic Bulk CMOS Passive Circulator Using 25% Duty-Cycle Clock

A circulator, which is a non-reciprocal device, is widely used in full-duplex systems, future communication and sensing networks, and quantum computing, and it is difficult to implement a passive topology on a chip. Based on switch-based spatio-temporal conductivity modulation, in this study, we design and implement a non-magnetic on-chip passive circulator operating at the Ku band in a 90-nm bulk CMOS technology using a 25% duty-cycle I/Q clock signal. With the virtue of the four-phase non-overlapping clock signal, the proposed circulator achieves a 3.9 dB transmitter (TX)-to-antenna (ANT) and a 4.0 dB ANT-to-receiver (RX) insertion loss with a 1-dB bandwidth of 2.7 GHz (21.4%). The TX-to-RX isolation is better than 17.2 dB, and the TX-to-ANT IIP3 and ANT-to-RX IIP3 are 19.7 dBm and 20.0 dBm, respectively, while occupying a die area of 1.55 mm × 1.15 mm. Although low-cost bulk CMOS technology is used, competitive isolation, linearity performance, and isolation bandwidth are achieved in the proposed design.
On the Goos-Hänchen effect in neutron optics

The Goos-Hanchen effect, a longitudinal shift of a wave beam at total inner reflection, is a well-known optical phenomenon. It was discovered in 1947 and have been observed many times at reflection of micro- and ultrasonic waves since then. Here we present an elementary theory of the GH. effect to describe reflection of a massive particle and demonstrate how the shift is related to delay time at reflection. It is shown that giant positive or negative longitudinal shifts of the neutron beam may occur at neutron reflection from some specially manufactured planar system. The possibility of delay time measurement at neutron reflection and direct experimental observation of the GH shift are also discussed.
Antibiofilm Action of Plant Terpenes in Salmonella Strains: Potential Inhibitors of the Synthesis of Extracellular Polymeric Substances

Salmonella can form biofilms that contribute to its resistance in food processing environments. Biofilms are a dense population of cells that adhere to the surface, creating a matrix composed of extracellular polymeric substances (EPS) consisting mainly of polysaccharides, proteins, and eDNA. Remarkably, the secreted substances, including cellulose, curli, and colanic acid, act as protective barriers for Salmonella and contribute to its resistance and persistence when exposed to disinfectants. Conventional treatments are mostly ineffective in controlling this problem; therefore, exploring anti-biofilm molecules that minimize and eradicate Salmonella biofilms is required. The evidence indicated that terpenes effectively reduce biofilms and affect their three-dimensional structure due to the decrease in the content of EPS. Specifically, in the case of Salmonella, cellulose is an essential component in their biofilms, and its control could be through the inhibition of glycosyltransferase, the enzyme that synthesizes this polymer. The inhibition of polymeric substances secreted by Salmonella during biofilm development could be considered a target to reduce its resistance to disinfectants, and terpenes can be regarded as inhibitors of this process. However, more studies are needed to evaluate the effectiveness of these compounds against Salmonella enzymes that produce extracellular polymeric substances.
Health-Promoting Behaviors among Older Adults with Noncommunicable Diseases in Rural and Urban Areas during the New Normal Post-COVID-19 Era: A Structural Equation Modeling Analysis

This study aimed to develop and test a causal relationship among perceived self-efficacy (PSE), health literacy (HL), access to COVID-19 preventive material (ACPM), social networks (SN), and health-promoting behaviors (HPBs). Multistage stratified random sampling was used to recruit 250 older adults with noncommunicable diseases (NCDs) from Thai urban and rural communities. The data were collected with self-reported questionnaires. Data analyses used descriptive statistics and structural equation modeling. The results indicated that participants in urban communities had higher PSE, ACPM, HL, SN, and HPBs than rural participants. The fitness parameters of the modified model (χ2 = 71.936, df = 58, p-value = 0.103, χ2/df = 1.240; root mean square error of approximation (RMSEA) = 0.031; standardized root mean square residual (SRMR) = 0.042; goodness of fit index (GFI) = 0.964; normed-fit index (NFI) = 0.964; comparative fit index (CFI) = 0.993) indicated its suitability as the research model. HPBs were directly positively influenced by PSE (β = 0.40, p < 0.001), ACPM (β = 0.24, p < 0.001), HL (β = 0.19, p < 0.01), and SN (β = 0.01, p < 0.05). Therefore, taking all predicting variables together could explain 81.0% of the variance in HPBs. Multidisciplinary healthcare teams could use these findings to establish proper interventions or healthcare activities to increase HPBs among older adults, particularly in this era of the “new normal”.
PNPLA3(I148M) Inhibits Lipolysis by Perilipin-5-Dependent Competition with ATGL

The single nucleotide polymorphism I148M of the lipase patatin-like phospholipase domain containing 3 (PNPLA3) is associated with an unfavorable prognosis in alcoholic and non-alcoholic steatohepatitis (ASH, NASH), with progression to liver cirrhosis and development of hepatocellular carcinoma. In this study, we investigated the mechanistic interaction of PNPLA3 with lipid droplet (LD)-associated proteins of the perilipin family, which serve as gatekeepers for LD degradation. In a collective of 106 NASH, ASH and control liver samples, immunohistochemical analyses revealed increased ballooning, inflammation and fibrosis, as well as an accumulation of PNPLA3–perilipin 5 complexes on larger LDs in patients homo- and heterozygous for PNPLA3(I148M). Co-immunoprecipitation demonstrated an interaction of PNPLA3 with perilipin 5 and the key enzyme of lipolysis, adipose triglyceride lipase (ATGL). Localization studies in cell cultures and human liver showed colocalization of perilipin 5, ATGL and PNPLA3. Moreover, the lipolytic activity of ATGL was negatively regulated by PNPLA3 and perilipin 5, whereas perilipin 1 displaced PNPLA3 from the ATGL complex. Furthermore, ballooned hepatocytes, the hallmark of steatohepatitis, were positive for PNPLA3 and perilipins 2 and 5, but showed decreased perilipin 1 expression with respect to neighboured hepatocytes. In summary, PNPLA3- and ATGL-driven lipolysis is significantly regulated by perilipin 1 and 5 in steatohepatitis.
Xiaochaihu Decoction Treatment of Chicken Colibacillosis by Improving Pulmonary Inflammation and Systemic Inflammation

Chicken colibacillosis—the most common disease of poultry, is caused mainly by avian pathogenic Escherichia coli (APEC). It has a major impact on the poultry industry worldwide. The present study was conducted to investigate the therapeutic effects of Xiaochaihu Decoction (XCHD) supplementation on clinical manifestation, organ index, bacterial load in organ and inflammatory mediators in a chicken model challenged with APEC. The results showed that all doses of XCHD significantly elevated the survival rate of infected chickens. XCHD improved the clinical signs of infected chickens, reduced the organ index, reduced the bacterial load of organs, and inhibited the secretion of serum and pulmonary inflammatory factors IL-1β, IL-6 and TNF- α. Taken together, this study demonstrates that XCHD had protective effects on APEC-infected chickens. Its mechanism includes anti-inflammatory and antibacterial effects. These findings may contribute to the further study of the mechanism of the formula and the prevention or treatment of colibacillosis in poultry. The significance of this study is that it provides a certain theoretical basis for the replacement of antibiotics by XCHD.
Kindlin2 enables EphB/ephrinB bi-directional signaling to support vascular development

Kindlin2 supports EphB4/ephrinB2 bi-directional signaling functions by associating with a highly conserved NIYY motif in the ephrinB2 cytoplasmic tail to promote ephrinB2 clustering and EphB4 activation, thereby enabling arteriovenous segregation during embryonic development. Direct contact between cells expressing either ephrin ligands or Eph receptor tyrosine kinase produces diverse developmental responses. Transmembrane ephrinB ligands play active roles in transducing bi-directional signals downstream of EphB/ephrinB interaction. However, it has not been well understood how ephrinB relays transcellular signals to neighboring cells and what intracellular effectors are involved. Here, we report that kindlin2 can mediate bi-directional ephrinB signaling through binding to a highly conserved NIYY motif in the ephrinB2 cytoplasmic tail. We show this interaction is important for EphB/ephrinB-mediated integrin activation in mammalian cells and for blood vessel morphogenesis during zebrafish development. A mixed two-cell population study revealed that kindlin2 (in ephrinB2-expressing cells) modulates transcellular EphB4 activation by promoting ephrinB2 clustering. This mechanism is also operative for EphB2/ephrinB1, suggesting that kindlin2-mediated regulation is conserved for EphB/ephrinB signaling pathways. Together, these findings show that kindlin2 enables EphB4/ephrinB2 bi-directional signal transmission. Graphical Abstract
Novel, Innovative Models to Study Ischemia/Reperfusion-Related Redox Damage in Organ Transplantation

The implementation of ex vivo organ machine perfusion (MP) into clinical routine undoubtedly helped to increase the donor pool. It enables not just organ assessment, but potentially regeneration and treatment of marginal organs in the future. During organ procurement, redox-stress triggered ischemia-reperfusion injury (IRI) is inevitable, which in addition to pre-existing damage negatively affects such organs. Ex vivo MP enables to study IRI-associated tissue damage and its underlying mechanisms in a near to physiological setting. However, research using whole organs is limited and associated with high costs. Here, in vitro models well suited for early stage research or for studying particular disease mechanisms come into play. While cell lines convince with simplicity, they do not exert all organ-specific functions. Tissue slice cultures retain the three-dimensional anatomical architecture and cells remain within their naïve tissue-matrix configuration. Organoids may provide an even closer modelling of physiologic organ function and spatial orientation. In this review, we discuss the role of oxidative stress during ex vivo MP and the suitability of currently available in vitro models to further study the underlying mechanisms and to pretest potential treatment strategies.
Spectrophotometric Determination of Lisinopril Drug by Oxidative Coupling Reaction with 4-aminonaphthalene-1- sulfonic acid Reagent

A simple, rapid and sensitive spectrophotometric method for determination of Lisinopril (LS) in both pure form and pharmaceutical preparations has been reported. The adapted technique based on utilization 4-aminonaphthalene-1-sulfonic acid as a Chromogenic reagent through an oxidative coupling reaction with Lisinopril and Potassium Peroxydisulfate (oxidation agent) in acidic medium to form green dye soluble product absorption maxima at 612 nm. Linearity was in the range 2–43 μg ml-1. The values of molar absorption coefficient (ε), correlation coefficient and Sandel’s index were found to be 10.3808 × 103 L. mole-1 cm-1, 0.9995 and 0.00343 µg. cm-2 respectively. The average of recovery % was 100.067. Detection Limit and quantitative limit were 0.0343 µg/ml and 0.1143 µg/ml. The proposed method has been successfully applied in the determination of preparations containing lisinopril.