Miracle-dz/UniFAR-FTUs huggingface dataset:
Traumatic Brain Injury Precipitates Cognitive Impairment and Extracellular Aβ Aggregation in Alzheimer's Disease Transgenic Mice

Traumatic brain injury (TBI) has become a signature wound of the wars in Iraq and Afghanistan. Many American soldiers, even those undiagnosed but likely suffering from mild TBI, display Alzheimer's disease (AD)-like cognitive impairments, suggesting a pathological overlap between TBI and AD. This study examined the cognitive and neurohistological effects of TBI in presymptomatic APP/PS1 AD-transgenic mice. AD mice and non-transgenic (NT) mice received an experimental TBI on the right parietal cortex using the controlled cortical impact model. Animals were trained in a water maze task for spatial memory before TBI, and then reevaluated in the same task at two and six weeks post-TBI. The results showed that AD mice with TBI made significantly more errors in the task than AD mice without TBI and NT mice regardless of TBI. A separate group of AD mice and NT mice were evaluated neurohistologically at six weeks after TBI. The number of extracellular beta-amyloid (Aβ)-deposits significantly increased by at least one fold in the cortex of AD mice that received TBI compared to the NT mice that received TBI or the AD and NT mice that underwent sham surgery. A significant decrease in MAP2 positive cells, indicating neuronal loss, was observed in the cortex of both the AD and NT mice that received TBI compared to the AD and NT mice subjected to sham surgery. Similar changes in extracellular Aβ deposits and MAP2 positive cells were also seen in the hippocampus. These results demonstrate for the first time that TBI precipitates cognitive impairment in presymptomatic AD mice, while also confirming extracellular Aβ deposits following TBI. The recognition of this pathological link between TBI and AD should aid in developing novel treatments directed at abrogating cellular injury and extracellular Aβ deposition in the brain.
Rack-Aware Regenerating Codes for Data Centers

Erasure coding is widely used for massive storage in data centers to achieve high fault tolerance and low storage redundancy. Since the cross-rack communication cost is often high, it is critical to design erasure codes that minimize the cross-rack repair bandwidth during failure repair. In this paper, we analyze the optimal trade-off between storage redundancy and cross-rack repair bandwidth specifically for data centers, subject to the condition that the original data can be reconstructed from a sufficient number of any non-failed nodes. We characterize the optimal trade-off curve under functional repair, and propose a general family of erasure codes called rack-aware regenerating codes (RRC), which achieve the optimal trade-off. We further propose exact repair constructions of RRC that have minimum storage redundancy and minimum cross-rack repair bandwidth, respectively. We show that (i) the minimum storage redundancy constructions support a wide range of parameters and have cross-rack repair bandwidth that is strictly less than that of the classical minimum storage regenerating codes in most cases, and (ii) the minimum cross-rack repair bandwidth constructions support all the parameters and have less cross-rack repair bandwidth than that of the minimum bandwidth regenerating codes for almost all of the parameters.
Impacts of Global Wildfire Aerosols on Direct Radiative , Cloud and 1 ! Surface-Albedo Effects Simulated with CAM 5 2 ! 3 !

3! Yiquan Jiang, Zheng Lu, Xiaohong Liu, Yun Qian, Kai Zhang, Yuhang Wang 4! and Xiu-Qun Yang 5! 6! 7! 1 CMA-NJU Joint Laboratory for Climate Prediction Studies, Institute for Climate 8! and Global Change Research, School of Atmospheric Sciences, Nanjing University, 9! Nanjing, China 10! 11! 2 Department of Atmospheric Science, University of Wyoming 12! 13! 3 Pacific Northwest National Laboratory, Richland, Washington, USA 14! 15! 4 School of Earth and Atmospheric Sciences, Georgia Institute of Technology, Atlanta, 16! Georgia, USA 17! 18! 19! 20! *Corresponding author: 21! 22! Dr. Xiaohong Liu 23! Department of Atmospheric Science 24! University of Wyoming 25! Laramie, WY 82071 26! Phone (307) 766-3225 27! E-mail: xliu6@uwyo.edu 28! 29!
Chemotherapy for soft tissue sarcoma

Soft tissue sarcoma is a term used to describe a heterogeneous group of many rare tumors. Since the initial description of activity of doxorubicin, several additional agents have been brought to bear in the treatment of these diseases. Despite 2 recent drug approvals, doxorubicin and ifosfamide remain the most effective chemotherapy drugs available for the treatment of majority of these tumors. Optimal dosing and administration influence outcomes because of the steep dose‐response curves associated with these agents. The debate endures regarding whether patients who have advanced disease should routinely receive single agents sequentially or in combination. Adjuvant therapy remains similarly controversial, although meta‐analyses do support its use. Contemporary treatment of soft tissue sarcoma routinely incorporates additional lines of treatment that have become available over the last 15 years. Fixed‐dose‐rate gemcitabine with or without docetaxel is a standard second‐line treatment. In keeping with the paradigm shift favoring subset‐specific therapy, several recent approvals are linked with specific sarcoma subtypes. Eribulin has recently been approved on the basis of improved overall survival for patients with adipocytic sarcomas, and trabectedin is now approved in the United States for patients with leiomyosarcoma and liposarcoma. Within the spectrum of targeted therapies, pazopanib is approved for all nonadipocytic sarcomas, and imatinib is approved for dermatofibrosarcoma protuberans. Each of these drugs represents incremental rather than radical progress, although they constitute important and much needed treatment options for patients with these diseases. Cancer 2016;122:2952‐2960. © 2016 American Cancer Society.
Relationship of Anthropometric and Training Characteristics with Race Performance in Endurance and Ultra-Endurance Athletes

A variety of anthropometric and training characteristics have been identified as predictor variables for race performance in endurance and ultra-endurance athletes. Anthropometric characteristics such as skin-fold thicknesses, body fat, circumferences and length of limbs, body mass, body height, and body mass index were bi-variately related to race performance in endurance athletes such as swimmers in pools and in open water, in road and mountain bike cyclists, and in runners and triathletes over different distances. Additionally, training variables such as volume and speed were also bi-variately associated with race performance. Multi-variate regression analyses including anthropometric and training characteristics reduced the predictor variables mainly to body fat and speed during training units. Further multi-variate regression analyses including additionally the aspects of previous experience such as personal best times showed that mainly previous best time in shorter races were the most important predictors for ultra-endurance race times. Ultra-endurance athletes seemed to prepare differently for their races compared to endurance athletes where ultra-endurance athletes invested more time in training and completed more training kilometers at lower speed compared to endurance athletes. In conclusion, the most important predictor variables for ultra-endurance athletes were a fast personal best time in shorter races, a low body fat and a high speed during training units.
Airway Hyperresponsiveness: New Insights into the Pathogenesis

Abstract Airway hyperresponsiveness (AHR) is the most characteristic clinical feature of asthma. The pathogenesis of AHR in asthma is characterized by a variety of epithelial, microbial, and inflammatory triggers on one hand and abnormalities of effector structures in the airways such as smooth muscle cells, blood vessels, and nerves on the other hand. Obesity is increasingly recognized as an important additional factor in the diagnosis and the pathogenesis of AHR in asthma. It is important to note that structural changes in the asthmatic airway can persist in the absence of inflammation. This may be one reason for the observation that potent new antiinflammatory drugs for the treatment of asthma have only little impact on AHR. New therapeutic strategies are, therefore, needed to modulate structural and functional changes in the airways, especially in patients with treatment-resistant severe asthma.
Multicenter prospective cohort study of the incidence of adverse events associated with cosmetic dermatologic procedures: lasers, energy devices, and injectable neurotoxins and fillers.

IMPORTANCE Common noninvasive to minimally invasive cosmetic dermatologic procedures are widely believed to be safe given the low incidence of reported adverse events, but reliable incidence data regarding adverse event rates are unavailable to date. OBJECTIVE To assess the incidence of adverse events associated with noninvasive to minimally invasive cosmetic dermatologic procedures, including those involving laser and energy devices, as well as injectable neurotoxins and fillers. DESIGN, SETTING, AND PARTICIPANTS A multicenter prospective cohort study (March 28, 2011, to December 30, 2011) of procedures performed using laser and energy devices, as well as injectable neurotoxins and soft-tissue augmentation materials, among 8 geographically dispersed US private and institutional dermatology outpatient clinical practices focused on cosmetic dermatology, with a total of 23 dermatologists. Participants represented a consecutive sample of 20 399 cosmetic procedures. Data acquisition was for 3 months (13 weeks) per center, with staggered start dates to account for seasonal variation. EXPOSURES Web-based data collection daily at each center to record relevant procedures, by category type and subtype. Adverse events were detected by (1) initial observation by participating physicians or staff; (2) active ascertainment from patients, who were encouraged to self-report after their procedure; and (3) follow-up postprocedural phone calls to patients by staff, if appropriate. When adverse events were not observed by physicians but were suspected, follow-up visits were scheduled within 24 hours to characterize these events. Detailed information regarding each adverse event was entered into an online form. MAIN OUTCOMES AND MEASURES The main outcome was the total incidence of procedure-related adverse events (total adverse events divided by total procedures performed), as verified by clinical examination. RESULTS Forty-eight adverse events were reported, for a rate of 0.24% (95% CI, 0.18%-0.31%). Overall, 36 procedures resulted in at least 1 adverse event, for a rate of 0.18% (95% CI, 0.13%-0.25%). No serious adverse events were reported. Adverse events were infrequently associated with known risk factors. CONCLUSIONS AND RELEVANCE Noninvasive to minimally invasive cosmetic dermatologic procedures, including energy, neurotoxin, and filler procedures, are safe when performed by experienced board-certified dermatologists. Adverse events occur in less than 1% of patients, and most of these are minor and transient.
Pepsin and Its Importance for Functional Dyspepsia: Relic, Regulator or Remedy?

Background: Functional dyspepsia is a heterogeneous disorder lacking an established therapeutic strategy. Historical treatment attempts with pepsin products were shrugged off, as a simple calculation shows that quantitative substitution is pointless. However, such attempts might have been right for the wrong reason. Summary: Today, the role of pepsins is primarily seen in the provision of signalling amino acids (especially phenylalanine and tryptophan) and peptides, which initiate processes promoting digestion. Proteolysis benefits from pepsin variants showing, contrary to common belief, activities of up to a pH value of 5.0. Non-clinical and clinical studies support the view that liberated amino acids produce a variety of direct and indirect effects. Signal chains stimulated by (mostly aromatic) amino acids lead to secretion of gastrin and cholecystokinin (CCK), mediated, respectively, by CCK2 (gastrin) and Ca2+-sensing receptors in the parietal cell, and Ca2+-sensing receptors in the antral and duodenal mucosa. Thus, CCK effects such as secretion of pancreatic enzymes and promotion of gastric accommodation are (also) consequential to peptic liberation of amino acids. Key Message: As functional dyspepsia represents a heterogeneous disorder, it may be intriguing to view pepsin as a potential (although still to be proven) treatment modality, distinguished by a diversity of pro-digestive effects.
Usability evaluation of a locomotor therapy device considering different strategies

Abstract Usability of medical devices is one of the main determining factors in preventing use errors in treatment and strongly correlates to patient safety and quality of treatment. This thesis demonstrates the usability testing and evaluation of a prototype for locomotor therapy of infants. Therefore, based on the normative requirements of the EN 62366, a concept combined of evaluation procedures and assessing methods was created to enable extensive testing and analysis of the different aspects of usability. On the basis of gathered information weak points were identified and appropriate measures were presented to increase the usability and operating safety of the locomotor prototype. The overall outcome showed an usability value of 77.4% and an evaluation score of 6.99, which can be interpreted as “satisfactory”.
Stabilization in H

It is shown that for H∞ R (D) functions f1 and f2 with inf z∈D (|f1(z)|+ |f2(z)|) ≥ δ > 0 and f1 being positive on the real zeros of f2, then there exists H∞ R (D) functions g2 and g1, g−1 1 with norm controlled by a constant depending only on δ and g1f1 + g2f2 = 1 ∀z ∈ D. These results are connected to the computation of the stable rank of the algebra H∞ R (D) and to results in Control Theory.
Ppar&ggr; Expression in T Cells as a Prognostic Marker of Sepsis

ABSTRACT Translating murine data to the human situation, we proposed that the level of peroxisome proliferator-activated receptor &ggr; (PPAR&ggr;) expression in T cells from septic patients correlates with clinical outcome. In this preliminary report, we analyzed PPAR&ggr; mRNA expression in CD3+ T cells derived from blood of a very small number of septic patients (n = 18) on various days up to 2 weeks after the initial diagnosis. CD3+ T cell count was determined by flow cytometry. T cells from n = 11 healthy donors were included as controls. Maximal PPAR&ggr; mRNA expression was observed on the day of sepsis diagnosis (day 0; 5,896 ± 1,523 copies PPAR&ggr; mRNA/25 ng mRNA, *P < 0.05 vs. controls). In contrast, the number of CD3+ T cells was significantly decreased in septic patients compared with healthy controls (296 ± 31 vs. 1,803 ± 134 T cells/&mgr;L blood, ***P < 0.001). Setting two arbitrary limits: patients with a PPAR&ggr; expression in T cells higher than 7,000 copies/25 ng mRNA, of whom five of six patients died during the ICU stay, and patients with a T cell count below 100 T cells/&mgr;L blood, of whom five of eight patients died, we identified a correlation between sepsis survival and low T cell number, paired with high T cell-specific PPAR&ggr; expression. Among all 18 sepsis patients, four fulfilled the criteria for both arbitrary settings and all four of these patients subsequently died. We suggest that both high PPAR&ggr; expression in T cells and low absolute T cell number in blood of septic patients may have the potential as a new prognostic marker for a poor sepsis outcome.
[Anemia of chronic disease].

Anemi ved kronisk sykdom er i Vesten den vanligste formen for anemi hos hospitaliserte pasienter over 50 år. Diagnostikken kompliseres av at de klassiske biokjemiske parametrene, brukt til vurdering av jernstatus, påvirkes av immunaktiveringen som er forårsaket av grunnsykdommen.
Effect of selenium and vitamin E on the development of immunity to coccidiosis in chickens.

Six experiments were conducted using broiler chickens to study the effect of selenium (Se) or vitamin E supplementation of a corn-soybean meal diet on the immune response to coccidiosis. Immunized chickens fed diets supplemented with . 25 ppm Se or 100 IU vitamin E/kg of diet had increased body weight gain and feed intake and a tendency for lower feed conversion ratio than chickens fed unsupplemented diet after a challenge with 150,000 oocysts of Eimeria tenella. In two experiments, chickens fed . 25 and . 50 ppm of Se and immunized against E. tenella had higher body weight gain and a tendency for higher feed intake and lower feed conversion ratio than unsupplemented chickens when challenged with 150,000 oocysts of E. tenella. Except for a reduction on cecal lesion scores and blood packed cell volume in Experiments 1 and 4, respectively, no dietary effect was observed on cecal lesion score or blood packed cell volume of immunized chickens. Dietary supplementation with selenium or vitamin E reduced mortality and increased body weight gain of nonimmunized chickens infected with E. tenella in three of four experiments. These studies suggest that immunization of chickens against coccidiosis is enhanced by Se or vitamin E supplementation.
Investigation of the effects of curcumin, vitamin E and their combination in cisplatin-induced testicular apoptosis using immunohistochemical technique.

Objective Cisplatin is an effective antineoplastic agent used in cancer therapy. However, the use of cisplatin is restricted due to its toxic side effects. Alleviation of its side effects which restricts cisplatin use is highly important. We aimed to investigate the effects of curcumin, vitamin E and their combination in cisplatin induced testicular apoptosis. Material and methods Thirty-five Wistar albino male adult rats, weighing 300-350 g were divided randomly into five groups including seven rats in each as control, cisplatin, curcumin, vitamin E, and curcumin + vitamin E. On the posttest 5th day, rats were sacrificed, and their testes were removed. 4-5 μm sections from formalin fixed paraffin embedded testis tissues were stained both hematoxylin-eosin to analyze histologically and immunohistochemically to determine the expression of the apoptotic pathway proteins (Bax, Cas-3, Bcl-2). Results Increased histological damage with cisplatin administration was reduced in treatment, especially in combination therapy. Cas-3 and Bax protein immunostaining intensities H-scores were significantly increased but Bcl-2 was slightly decreased in the cisplatin group compared to the control. In all treatment groups Bax, Cas-3 decreased compared to cisplatin group however Bcl-2 decreased in the curcumin and vitamin E groups. Bax/Bcl-2 was the highest in the cisplatin, and decreased in all treatment groups in favor of control. Conclusion Cas-3 expression increased by cisplatin administration suggests that cisplatin causes apoptosis of germ cells. According to the present findings, cisplatin mainly caused testicular apoptosis through the Cas-3 and Bax apoptotic protein pathways. Cisplatin-induced testicular apoptosis can be prevented by administration of curcumin, vitamin E, and combination therapy.
Direct Measurement of the Full, Sequence-Dependent Folding Landscape of a Nucleic Acid

Nucleic acid hairpins provide a powerful model system for understanding macromolecular folding, with free-energy landscapes that can be readily manipulated by changing the hairpin sequence. The full shapes of energy landscapes for the reversible folding of DNA hairpins under controlled loads exerted by an optical force clamp were obtained by deconvolution from high-resolution, single-molecule trajectories. The locations and heights of the energy barriers for hairpin folding could be tuned by adjusting the number and location of G:C base pairs, and the presence and position of folding intermediates were controlled by introducing single-nucleotide mismatches.
Maximising average energy efficiency for two-user AWGN broadcast channel

Energy consumption has become an increasingly important aspect of wireless communications, from both an economical and environmental point of view. New enhancements are being placed on mobile networks to reduce the power consumption of both mobile terminals and base stations. This paper studies the achievable rate region of AWGN broadcast channels under Time-division, Frequency-division and Superposition coding, and locates the optimal energy-efficient rate-pair according to a comparison metric based on the average energy efficiency of the system. In addition to the transmit power, circuit power and signalling power are also incorporated in the energy efficiency function, with simulation results verifying that the Superposition coding scheme achieves the highest energy efficiency in an ideal, but non-realistic scenario, where the signalling power is zero. With moderate signalling power, the Frequency-division scheme is the most energy-efficient, with Superposition coding and Time-division becoming second and third best. Conversely, when the signalling power is high, both Time-division and Frequency-division schemes outperform Superposition coding. On the other hand, the Superposition coding scheme also incorporates rate-fairness into the system, which allows both users to transmit whilst maximising the energy efficiency.
Effects of mannan‐oligosaccharides and Lactobacillus acidophilus supplementation on growth performance, nutrient utilization and faecal characteristics in Murrah buffalo calves

A study of 120 days was undertaken to ascertain the effect of mannan-oligosaccharides (MOS) and Lactobacillus acidophilus supplementation on growth performance, nutrient utilization and faecal characteristics in Murrah buffalo calves. Twenty Murrah buffalo calves of 5-7 days old and 31 ± 2.0 kg of body weight (BW) were randomly assigned into four groups. Group I served as the control (CON) in which only basal diet (concentrate mixture and green fodder) was provided, without any supplementation. Mannan-oligosaccharides at 4 g/calf/day were supplemented as prebiotic to Group II (PRE), whereas Group III (PRO) received Lactobacillus acidophilus in the form of fermented milk as probiotic at 200 ml/calf/day having 108 CFU/ml and Group IV (SYN) was supplemented with both MOS and Lactobacillus acidophilus as synbiotic at similar dose. Final BW (kg), dry matter intake, average daily gain, feed conversion efficiency and structural growth measurements were improved (p < .05) in the treatment groups compared to control. Digestibility of neutral detergent fibre was higher (p < .05) in SYN followed by PRE and PRO than control. The faecal lactobacilli and bifidobacterium population was higher (p < .05) in all the supplemented groups with a concomitant reduction in faecal coliform count as compared to control. Faecal ammonia, lactate and pH were also altered favourably (p < .05) in all the supplemented groups as compared to CON. The faecal volatile fatty acids were higher (p < .05) in PRE, PRO and SYN group than CON. The incorporation of MOS and Lactobacillus acidophilus in diet either individually or in combination as synbiotic has the potential to improve the performance and faecal characteristics in Murrah buffalo calves; however, the observed responses among the treatment groups were more evident in the synbiotic fed group compared to individual supplementation of MOS and Lactobacillus acidophilus.