Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Large Cigarette Warning Labels on Smokers' Expected Longevity.

OBJECTIVES Smokers underestimate the health risks of smoking and overestimate their expected longevity. Warning labels on cigarette packs might help correct these misperceptions. METHODS We carried out an online study with 1200 smokers (18-62 years old), randomized to 3 conditions: text warning labels, pictorial warning labels, and a control group (water bottle labels). Warning labels were based on those proposed by the US Food and Drug Administration in 2010. Participants in each condition saw 4 randomly selected labels and rated their expected longevity and chances of surviving to age 75 after exposure. Analyses of covariance controlled for cigarettes per day and self-rated health. RESULTS Compared to control, both text and pictorial warnings reduced participants' expected longevity (text: mean = 76.8 years, pictorial: 77.3, control 79.4) and their estimated chances of living to 75 (text: 62.0%, pictorial: 63.0%, control 66.5%). The contrast between text and pictorial labels combined and control showed significantly reduced expected longevity (p = .011) and chances of living to 75 (p = .004). Differences between text and pictorial conditions were not statistically significant. CONCLUSIONS Large text or pictorial warnings on cigarette packs might help smokers develop a more accurate understanding of the effects of smoking on their longevity.
Efficiency Enhancement in Plasmonic IBC Solar Cells

: Silicon solar cells dominate photovoltaics but suffer from poor interaction with light. This work reports on progress regarding both spectral conversion and improved light interaction with the LIMA design [1]. This combines an efficient interdigitated back-contact (IBC) solar cell [2] with a silicon quantum dot (Si-QD) [3] to optimize the spectral distribution of the incident spectrum, and finally a front-side plasmon layer to optimize light interaction. Reflectivity after thickness and process optimization for a thin Ag layer and a Si 3 N 4 shows that plasmonic particle layers reduce reflectivity compared with an IBC with only a Si 3 N 4 anti-reflective coating layer. There is an increasing of the quantum efficiency in the infrared zone but losses remain in the UV zone which needs to be addressed.
Genetic polymorphisms are associated with the risk of gastric and colorectal cancers in a Han Chinese population

Here, we genotyped eleven single-nucleotide polymorphisms (SNPs) and evaluated their association with the risk of developing gastric cancer (GC) or colorectal cancer (CRC) in 1,790 Han Chinese participants (588 GC patients, 499 CRC patients, and 703 healthy controls). Statistically analysis showed that the “C” allele of rs2689154 in MIPEPP2 was associated with a decreased risk of GC (odds ratio [OR] = 0.81, 95 % confidence interval [CI]: 0.66-0.99, P = 0.041), whereas the “T” allele of rs12615966 in LOC284998 was associated with a 1.29-fold increase in the risk of GC (OR = 1.29, 95% CI: 1.03-1.63, P = 0.029). Additionally, genetic model analyses showed that rs2689154 was associated with a reduced risk of GC under the recessive model (adjusted OR = 0.46, 95% CI: 0.22-0.98, P = 0.037), and rs12615966 in FOXF1 was associated with an increased risk of GC in both the dominant and log-additive models after adjusted for age and gender (adjusted OR = 1.36, 95% CI: 1.02-1.81, P = 0.033; adjusted OR = 1.36, 95% CI: 1.05-1.75, P = 0.018, respectively). We also observed that rs2178146 in FOXF1 was associated with an increased risk of CRC in the recessive model (adjusted OR = 1.90, 95% CI: 1.05-3.45, P = 0.034). Our results confirmed that rs2689154 in MIPEPP2 was significantly decreased GC risk, but rs12615966 in LOC284998 was significantly increased GC risk, and rs2178146 in FOXF1 was associated with increased CRC risk in the Han Chinese population.
Validation of the urgency questionnaire in Portuguese: A new instrument to assess overactive bladder syndrome

ABSTRACT Purpose Overactive Bladder (OAB) is a clinical condition characterized by symptoms reported by patients. Therefore, measurement instruments based on reported information are important for understanding its impact and treatment benefits. The aim of this study was to translate, culturally adapt and validate the Urgency Questionnaire (UQ) in Portuguese. Materials and Methods Initially, the UQ was translated and culturally adapted to Portuguese. Sixty-three volunteers were enrolled in the study and were interviewed for responding the Portuguese version of the UQ and the validated Portuguese version of the Overactive Bladder Questionnaire short-form (OABq-SF), used as the gold standard measurement for the validation process. Psychometric properties such as criterion validity, stability, and reliability were tested. Results Forty-six subjects were included in the symptomatic group (presence of “urgency”), and seventeen were included in the asymptomatic group (control group). There was difference between symptomatic and asymptomatic subjects on all of the subscales (p≤0.001). The UQ subscales correlated with the OABq-SF subscales (p≤0.01), except the subscale “time to control urgency” and the item “impact” from the visual analog scales (VAS). However, these scales correlated with the OABq-SF - Symptom Bother Scale. The UQ subscales demonstrated stability over time (p<0.05), but the subscale “fear of incontinence” and the item “severity” of the VAS did not. All of the UQ subscales showed internal consistencies that were considered to be good or excellent. Conclusion The Portuguese version of the UQ proved to be a valid tool for the evaluation of OAB in individuals whose native language is Portuguese.
Adversarial Error Resilience in Distributed Storage Using MRD Codes and MDS Array Codes

This paper presents a novel coding scheme for distributed storage systems containing nodes with adversa ri l errors. The key challenge in such systems is the propagation of the erroneous data from a single corrupted node to the rest of the system during node repair process. We present a concatenate d coding scheme which is based on two types of codes: maximum rank distance (MRD) code as an outer code and optimal repair maximal distance separable (MDS) array code as an inner code . We prove that this coding scheme attains the upper bound on the resilience capacity, i.e., amount of data stored reliab ly in a system with a limited number of corrupted nodes.
Multiple Inhibitory Mechanisms of Lidocaine on Bradykinin Receptor Activity in Model Sensory Neurons

Background and Objectives Local anesthetics (LAs) are often infiltrated subcutaneously for localized perioperative numbing. In addition to blocking nerve conduction, LAs act on pathways used by a variety of pain-inducing and inflammatory mediators. We describe the effects in isolated model sensory neurons of LAs on responses to the algogenic and sensitizing peptide, bradykinin (BK). Methods ND/7 sensory neurons were stimulated by different concentrations of BK in the presence or absence of LAs, with transient increases in intracellular calcium (&Dgr;[Ca+2]in) detected fluorometrically in fields of cells. Equilibrium saturable binding of radiolabeled BK also was conducted on the same type of cells, with and without LA. Results Responses to low BK (5 nM) were inhibited by lidocaine at 1 mM (approximately 35% inhibition) and 10 mM (approximately 70% inhibition), whereas responses to high BK (100 nM) were unaffected by 1 mM yet inhibited (approximately 75%) by 10 mM lidocaine. Bupivacaine (1 and 2 mM) did not reduce peak &Dgr;[Ca+2]in (using 5 nM BK). Lidocaine's quaternary derivative, QX-314 (10 mM), also was ineffective on peak Ca+2 (5 nM BK). Saturation binding of BK showed that lidocaine lowered the binding capacity (Bmax) without changing the KD, consistent with noncompetitive inhibition. Conclusions At subclinical concentrations, lidocaine suppresses BK's activation of model sensory neurons. This effect adds to the known analgesic mechanisms of LAs and likely contributes to the reduction of postincisional pain.
Supervised Learning for Dynamical System Learning

Recently there has been substantial interest in spectral methods for learning dynamical systems. These methods are popular since they often offer a good tradeoff between computational and statistical efficiency. Unfortunately, they can be difficult to use and extend in practice: e.g., they can make it difficult to incorporate prior information such as sparsity or structure. To address this problem, we present a new view of dynamical system learning: we show how to learn dynamical systems by solving a sequence of ordinary supervised learning problems, thereby allowing users to incorporate prior knowledge via standard techniques such as L1 regularization. Many existing spectral methods are special cases of this new framework, using linear regression as the supervised learner. We demonstrate the effectiveness of our framework by showing examples where nonlinear regression or lasso let us learn better state representations than plain linear regression does; the correctness of these instances follows directly from our general analysis.
Network flow of mobile agents enhances the evolution of cooperation

We study the effect of contingent movement on the persistence of cooperation on complex networks with empty nodes. Each agent plays the Prisoner's Dilemma game with its neighbors and then it either updates the strategy depending on the payoff difference with neighbors or it moves to another empty node if not satisfied with its own payoff. If no neighboring node is empty, each agent stays at the same site. By extensive evolutionary simulations, we show that the medium density of agents enhances cooperation where the network flow of mobile agents is also medium. Moreover, if the movements of agents are more frequent than the strategy updating, cooperation is further promoted. In scale-free networks, the optimal density for cooperation is lower than other networks because agents get stuck at hubs. Our study suggests that keeping a smooth network flow is significant for the persistence of cooperation in ever-changing societies.
Fingerprint-Based Attendance Management System

In recent time, there has been high level of impersonation experienced on a daily basis in both private and public sectors, the ghost worker syndrome which has become a menace across all tiers of government, employers concerns over the levels of employee absence in their workforce and the difficulty in managing student attendance during lecture periods. Fingerprints are a form of biometric identification which is unique and does not change in one’s entire lifetime. This paper presents the attendance management system using fingerprint technology in a university environment. It consists of two processes namely; enrolment and authentication. During enrolment, the fingerprint of the user is captured and its unique features extracted and stored in a database along with the users identity as a template for the subject. The unique features called minutiae points were extracted using the Crossing Number (CN) method which extracts the ridge endings and bifurcations from the skeleton image by examining the local neighborhoods of each ridge pixel using a 3 x 3 window. During authentication, the fingerprint of the user is captured again and the extracted features compared with the template in the database to determine a match before attendance is made. The fingerprint-based attendance management system was implemented with Microsoft’s C# on the. NET framework and Microsoft’s Structured Query Language (SQL) Server 2005 as the backend. The experimental result shows that the developed system is highly efficient in the verification of users fingerprint with an accuracy level of 97.4%. The average execution time for the developed system was 4.29 seconds as against 18.48 seconds for the existing system. Moreover, the result shows a well secured and reliable system capable of preventing impersonation.
How Did Zika Virus Emerge in the Pacific Islands and Latin America?

ABSTRACT The unexpected emergence of Zika virus (ZIKV) in the Pacific Islands and Latin America and its association with congenital Zika virus syndrome (CZVS) (which includes microcephaly) and Guillain-Barré syndrome (GBS) have stimulated wide-ranging research. High densities of susceptible Aedes spp. , immunologically naive human populations, global population growth with increased urbanization, and escalation of global transportation of humans and commercial goods carrying vectors and ZIKV undoubtedly enhanced the emergence of ZIKV. However, flavivirus mutations accumulate with time, increasing the likelihood that genetic viral differences are determinants of change in viral phenotype. Based on comparative ZIKV complete genome phylogenetic analyses and temporal estimates, we identify amino acid substitutions that may be associated with increased viral epidemicity, CZVS, and GBS. Reverse genetics, vector competence, and seroepidemiological studies will test our hypothesis that these amino acid substitutions are determinants of epidemic and neurotropic ZIKV emergence.
IKK inhibition by BMS-345541 suppresses breast tumorigenesis and metastases by targeting GD2+ cancer stem cells

We have identified that the ganglioside GD2 is a marker for breast cancer stem cells (BCSCs), and that targeting the enzyme GD3 synthase (GD3S, which regulates GD2 biosynthesis) reduces breast tumorigenesis. The pathways regulating GD2 expression, and their anomalous functions in BCSC, are unclear. Proteomic analysis of GD2+ and GD2- cells from breast cancer cell lines revealed the activation of NFκB signaling in GD2+ cells. Dose- and time-dependent suppression of NFκB signaling by the small molecule inhibitor BMS-345541 reduced GD2+ cells by > 90%. Likewise, BMS-345541 inhibited BCSC GD3S expression, mammosphere formation, and cell migration/invasion in vitro. Breast tumor-bearing mice treated with BMS-345541 showed a statistically significant decrease in tumor volume and exhibited prolonged survival compared to control mice, with a median survival of 78 d for the BMS-345541-treated group vs. 58 d for the controls. Moreover, in an experimental metastases model, treatment with BMS-345541 reduced the lung metastases by > 5-fold. These data suggest that GD2 expression and function, and NFκB signaling, are related, and they control BCSCs tumorigenic characteristics. Thus, the suppression of NFκB signaling by BMS-345541 is a potentially important advance in controlling breast cancer growth and metastases.
Comparative Genomic and Transcriptomic Analysis of Tandemly and Segmentally Duplicated Genes in Rice

Tandem and segmental duplications significantly contribute to gene family expansion and genome evolution. Genome-wide identification of tandem and segmental genes has been analyzed before in several plant genomes. However, comparative studies in functional bias, expression divergence and their roles in species domestication are still lacking. We have carried out a genome-wide identification and comparative analysis of tandem and segmental genes in the rice genome. A total of 3,646 and 3,633 pairs of tandem and segmental genes, respectively, were identified in the genome. They made up around 30% of total annotated rice genes (excluding transposon-coding genes). Both tandem and segmental duplicates showed different physical locations and exhibited a biased subset of functions. These two types of duplicated genes were also under different functional constrains as shown by nonsynonymous substitutions per site (Ka) and synonymous substitutions per site (Ks) analysis. They are also differently regulated depending on the tissues and abiotic and biotic stresses based on transcriptomics data. The expression divergence might be related to promoter differentiation and DNA methylation status after tandem or segmental duplications. Both tandem and segmental duplications differ in their contribution to genetic novelty but evidence suggests that they play their role in species domestication and genome evolution.
MOF Suppresses Replication Stress and Contributes to Resolution of Stalled Replication Forks

ABSTRACT The human MOF (hMOF) protein belongs to the MYST family of histone acetyltransferases and plays a critical role in transcription and the DNA damage response. MOF is essential for cell proliferation; however, its role during replication and replicative stress is unknown. Here we demonstrate that cells depleted of MOF and under replicative stress induced by cisplatin, hydroxyurea, or camptothecin have reduced survival, a higher frequency of S-phase-specific chromosome damage, and increased R-loop formation. MOF depletion decreased replication fork speed and, when combined with replicative stress, also increased stalled replication forks as well as new origin firing. MOF interacted with PCNA, a key coordinator of replication and repair machinery at replication forks, and affected its ubiquitination and recruitment to the DNA damage site. Depletion of MOF, therefore, compromised the DNA damage repair response as evidenced by decreased Mre11, RPA70, Rad51, and PCNA focus formation, reduced DNA end resection, and decreased CHK1 phosphorylation in cells after exposure to hydroxyurea or cisplatin. These results support the argument that MOF plays an important role in suppressing replication stress induced by genotoxic agents at several stages during the DNA damage response.
Three-tier regulation of cell number plasticity by neurotrophins and Tolls in Drosophila

Cell number plasticity is coupled to circuitry in the nervous system, adjusting cell mass to functional requirements. In mammals, this is achieved by neurotrophin (NT) ligands, which promote cell survival via their Trk and p75NTR receptors and cell death via p75NTR and Sortilin. Drosophila NTs (DNTs) bind Toll receptors instead to promote neuronal survival, but whether they can also regulate cell death is unknown. In this study, we show that DNTs and Tolls can switch from promoting cell survival to death in the central nervous system (CNS) via a three-tier mechanism. First, DNT cleavage patterns result in alternative signaling outcomes. Second, different Tolls can preferentially promote cell survival or death. Third, distinct adaptors downstream of Tolls can drive either apoptosis or cell survival. Toll-6 promotes cell survival via MyD88–NF-&kgr;B and cell death via Wek-Sarm-JNK. The distribution of adaptors changes in space and time and may segregate to distinct neural circuits. This novel mechanism for CNS cell plasticity may operate in wider contexts.
The Land Gini Coefficient and Its Application for Land Use Structure Analysis in China

We introduce the Gini coefficient to assess the rationality of land use structure. The rapid transformation of land use in China provides a typical case for land use structure analysis. In this study, a land Gini coefficient (LGC) analysis tool was developed. The land use structure rationality was analyzed and evaluated based on statistical data for China between 1996 and 2008. The results show: (1)The LGC of three major land use types–farmland, built-up land and unused land–was smaller when the four economic districts were considered as assessment units instead of the provinces. Therefore, the LGC is spatially dependent; if the calculation unit expands, then the LGC decreases, and this relationship does not change with time. Additionally, land use activities in different provinces of a single district differed greatly. (2) At the national level, the LGC of the three main land use types indicated that during the 13 years analyzed, the farmland and unused land were evenly distributed across China. However, the built-up land distribution was relatively or absolutely unequal and highlights the rapid urbanization in China. (3) Trends in the distribution of the three major land use types are very different. At the national level, when using a district as the calculation unit, the LGC of the three main land use types increased, and their distribution became increasingly concentrated. However, when a province was used as the calculation unit, the LGC of the farmland increased, while the LGC of the built-up and unused land decreased. These findings indicate that the distribution of the farmland became increasingly concentrated, while the built-up land and unused land became increasingly uniform. (4) The LGC analysis method of land use structure based on geographic information systems (GIS) is flexible and convenient.
Social Monogamy in Nonhuman Primates: Phylogeny, Phenotype, and Physiology

Monogamy as a social system has been both a scientific puzzle and a sociocultural issue for decades. In this review, we examine social monogamy from a comparative perspective with a focus on primates, our closest genetic relatives. We break down monogamy into component elements, including pair-bonding and partner preference, mate guarding or jealousy, social attachment, and biparental care. Our survey of primates shows that not all features are present in species classified as socially monogamous, in the same way that human monogamous relationships may not include all elements—a perspective we refer to as “monogamy à la carte. ” Our review includes a survey of the neurobiological correlates of social monogamy in primates, exploring unique or common pathways for the elemental components of monogamy. This compilation reveals that the components of monogamy are modulated by a suite of androgenic steroids, glucocorticoid hormones, the nonapeptide hormones oxytocin and vasopressin, and other neurotransmitter systems (e.g., dopamine and opioids). We propose that efforts to understand the biological underpinnings of complex human and animal sociosexual relationships will be well served by exploring individual phenotypic traits, as opposed to pursuing these questions with the assumption that monogamy is a unitary trait or a species-specific characteristic.
In search of quantum-limited contact resistance: understanding the intrinsic and extrinsic effects on the graphene–metal interface

Owing to its two-dimensional structure, graphene is extremely sensitive to surface contamination. Conventional processing techniques inevitably modify graphene’s intrinsic properties by introducing adsorbents and/or defects which limit device performance and understanding the intrinsic properties of graphene. Here we demonstrate femtosecond laser direct patterning of graphene microstructures, without the aid of resists or other chemicals, that enables us to study both intrinsic and extrinsic effects on the graphene–metal interface. The pulsed femtosecond laser was configured to ablate epitaxial graphene (EG) on a sub-micrometer scale and form a precisely defined region without damaging the surrounding material or substrate. The ablated area was sufficient to electrically isolate transfer length measurement structures and Hall devices for subsequent transport measurements. Using pristine and systematically contaminated surfaces, we found that Ni does not form bonds to EG synthesized on SiC in contrast to the well-known C–Ni bond formation for graphene synthesized on metals; known as end-contacting. Without end-contacting, the contact resistance (RC) of Ni to pristine and resist-contaminated EG are one and two orders of magnitude larger, respectively, than the intrinsic quantum limited contact resistance. The range of reported RC values is explained using carrier transmission probability, as exemplified by the Landauer–Büttiker model, which is dependent on the presence or absence of end-contacts and dopant/work-function mediated conduction. The model predicts the need for both end-contacts and a clean graphene–metal interface as necessary conditions to approach quantum limited contact resistance.