Miracle-dz/UniFAR-FTUs huggingface dataset:
In-Home Telerehabilitation Compared with Face-to-Face Rehabilitation After Total Knee Arthroplasty: A Noninferiority Randomized Controlled Trial.

BACKGROUND The availability of less resource-intensive alternatives to home visits for rehabilitation following orthopaedic surgeries is important, given the increasing need for home care services and the shortage of health resources. The goal of this trial was to determine whether an in-home telerehabilitation program is not clinically inferior to a face-to-face home visit approach (standard care) after hospital discharge of patients following a total knee arthroplasty. METHODS Two hundred and five patients who had a total knee arthroplasty were randomized before hospital discharge to the telerehabilitation group or the face-to-face home visit group. Both groups received the same rehabilitation intervention for two months after hospital discharge. Patients were evaluated at baseline (before total knee arthroplasty), immediately after the rehabilitation intervention (two months after discharge), and two months later (four months after discharge). The primary outcome measure was the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire at the last follow-up evaluation. Secondary outcome measures included the Knee Injury and Osteoarthritis Outcome Score (KOOS) questionnaire, functional and strength tests, and knee range of motion. The noninferiority margin was set at 9% for the WOMAC. RESULTS The demographic and clinical characteristics of the two groups of patients were similar at baseline. At the last follow-up evaluation, the mean differences between the groups with regard to the WOMAC gains, adjusted for baseline values, were near zero (for 182 patients in the per-protocol analysis): -1.6% (95% confidence interval [CI]: -5.6%, 2.3%) for the total score, -1.6% (95% CI: -5.9%, 2.8%) for pain, -0.7% (95% CI: -6.8%, 5.4%) for stiffness, and -1.8% (95% CI: -5.9%, 2.3%) for function. The confidence intervals were all within the predetermined zone of noninferiority. The secondary outcomes had similar results, as did the intention-to-treat analysis, which was conducted afterward for 198 patients. CONCLUSIONS Our results demonstrated the noninferiority of in-home telerehabilitation and support its use as an effective alternative to face-to-face service delivery after hospital discharge of patients following a total knee arthroplasty. LEVEL OF EVIDENCE Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
After-exercise heart rate variability is attenuated in postmenopausal women and unaffected by estrogen therapy

Objective:Delayed heart rate (HR) recovery in the immediate postexercise period has been linked to adverse cardiovascular prognosis. The after effects of an acute bout of exercise on HR modulation in postmenopausal women (PMW) and the influence of estrogen therapy are unknown. Methods:In 13 sedentary PMW (54 ± 2 y, mean ± SEM), we assessed HR variability (HRV) —an index of HR modulation—and the influence of estrogen therapy on HRV. HRV in the frequency domain was quantified during supine rest and again 60 minutes after treadmill exercise for 45 minutes, at 60% VO2peak. PMW were studied before and after 4 weeks of oral estradiol. To obtain reference values for the after effects of exercise on HRV in healthy young women, 14 premenopausal women (PreM) completed the identical exercise protocol. Results:Compared with PreM, PMW demonstrated lower high frequency (vagal modulation) and total HRV (P < 0.05) at rest. In PreM, all HRV values were similar before and after exercise. In contrast, in PMW after exercise, despite having identical HR to PreM, high frequency and total HRV were all lower (all P ⩽ 0.01) compared with pre-exercise HRV values. Estrogen therapy had no effect on pre or postexercise values for HRV. Conclusions:When compared with PreM, PMW have identical HR, but lower vagal HR modulation at rest and delayed HRV recovery after exercise. Estrogen does not restore baseline HRV or accelerate HRV recovery postexercise, suggesting aging rather than estrogen deficiency per se may lower HRV in PMW.
From Pictorial Structures to deformable structures

Pictorial Structures (PS) define a probabilistic model of 2D articulated objects in images. Typical PS models assume an object can be represented by a set of rigid parts connected with pairwise constraints that define the prior probability of part configurations. These models are widely used to represent non-rigid articulated objects such as humans and animals despite the fact that such objects have parts that deform non-rigidly. Here we define a new Deformable Structures (DS) model that is a natural extension of previous PS models and that captures the non-rigid shape deformation of the parts. Each part in a DS model is represented by a low-dimensional shape deformation space and pairwise potentials between parts capture how the shape varies with pose and the shape of neighboring parts. A key advantage of such a model is that it more accurately models object boundaries. This enables image likelihood models that are more discriminative than previous PS likelihoods. This likelihood is learned using training imagery annotated using a DS “puppet. ” We focus on a human DS model learned from 2D projections of a realistic 3D human body model and use it to infer human poses in images using a form of non-parametric belief propagation.
Platelet Ultrastructural Morphology and Morphometry in 10 Patients with MYH 9-Related Disease

MYH9-related disease is an autosomal dominant hereditary macro thrombocytopenia caused by mutations in the MYH9 gene which encodes the nonmuscular myosin heavy chain type IIA. The patients have mild clinical bleeding, grayish-blue inclusions in granulocytes and, in some cases, nephropathy, neurosensory deafness, and cataracts. The aim of our study was to assess the platelet ultra structure in MYH9-related disease with the help of morphometry. Ten patients with genetically confirmed MYH9-related disease were studied together with a group of 15 healthy individuals. The ultra structure of a minimum of 150 platelet sections for each patient was examined, and the morphometry of the main platelet traits was performed. We measured the size and shape of resting platelets, the diameter, number per platelet and number per unit of platelet area of the granules, dense bodies, mitochondria and lipid droplets. Moreover, we measured the percentage of platelet area occupied by open canalicular system and by glycogen masses. We compare the results between patients and controls using the one-way analysis of variance. We confirmed that MYH9-RD platelets are larger and rounder than normal platelets and they show expanded open canalicular system and increased membrane complexes. Moreover, we found that the size of α-granules and dense bodies was enlarged, and the amounts of mitochondria and glycogen, both related to cell energy metabolism, were significantly increased.
Synthesis and Compression Strength Properties of Composite Based on Sago Pulp Fiber Waste

Sago palm starch produced not only wild or semi-wild plant and only as a staple food for local people, but sago palm has become a commercial crop and an important source of starch for food and non-food industries. Especially for people in Sulawesi, most of the sago in some areas as a traditional food and industries materials. As a local food likes kapurung, bagea, food flavoring, sago noodle, various of snacks, sago perals, and dried refining sago starch. The one of the waste generated from sago processing is sago pulp. Nowadays, the sago pulp is only used for animal feed and composite fertilizer for plants. Characteristics of waste sago waste that can be used as a renewable composite material because it has a requirement as a composite material caused the fibrous and porous material has a cellular networks with interconnected pores. The fibers of the sago pulp have strength and rigidity. Synthesis composites fiber and matrix are required. Furthermore, the gypsum on this research was needed. In this research has been made composite based on fiber of sago pulp waste in diameter variation and measured composite physical properties using loading test machine. In this research, the compression strength test using tube method. The highest water content was 13.46% indicated accordance with Indonesian National Standard and Japan International Standard (JIS). The compression strength is intended to determine the composite resistance to loading at the bending point. It was observed that compression strength test on the ratio of fiber: gypsum: water (1:2:1) for diameter 5.5 cm, 4.5 cm, 3.5 cm and 2.5 cm were 0.1221 MPa, 0.0671 MPa, 0.1067 MPa, and 0.1091 MPa, respectively. In this case of the sample which 5.5 cm has the highest compression strength in 0.1221 MPa. It’s caused by density is poor when pressured process. The higher the density of the resulting composite board, the higher the fracture strength of the resulting particle.
A hybrid brain interface for a humanoid robot assistant

We present an advanced approach towards a semi-autonomous, robotic personal assistant for handicapped people. We developed a multi-functional hybrid brain-robot interface that provides a communication channel between humans and a state-of-the-art humanoid robot, Honda's Humanoid Research Robot. Using cortical signals, recorded, processed and translated by an EEG-based brain-machine interface (BMI), human-robot interaction functions independently of users' motor control deficits. By exploiting two distinct cortical activity patterns, P300 and event-related desynchronization (ERD), the interface provides different dimensions for robot control. An empirical study demonstrated the functionality of the BMI guided humanoid robot. All participants could successfully control the robot that accomplished a shopping task.
Fibrations in bicategories

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The Mu.Ta.Lig. Chemotheca: A Community-Populated Molecular Database for Multi-Target Ligands Identification and Compound-Repurposing

For every lead compound developed in medicinal chemistry research, numerous other inactive or less active candidates are synthetized/isolated and tested. The majority of these compounds will not be selected for further development due to a sub-optimal pharmacological profile. However, some poorly active or even inactive compounds could live a second life if tested against other targets. Thus, new therapeutic opportunities could emerge and synergistic activities could be identified and exploited for existing compounds by sharing information between researchers who are working on different targets. The Mu.Ta. Lig (Multi-Target Ligand) Chemotheca database aims to offer such opportunities by facilitating information exchange among researchers worldwide. After a preliminary registration, users can (a) virtually upload structures and activity data for their compounds with corresponding, and eventually known activity data, and (b) search for other available compounds uploaded by the users community. Each piece of information about given compounds is owned by the user who initially uploaded it and multiple ownership is possible (this occurs if different users uploaded the same compounds or information pertaining to the same compounds). A web-based graphical user interface has been developed to assist compound uploading, compounds searching and data retrieval. Physico-chemical and ADME properties as well as substructure-based PAINS evaluations are computed on the fly for each uploaded compound. Samples of compounds that match a set of search criteria and additional data on these compounds could be requested directly from their owners with no mediation by the Mu.Ta. Lig Chemotheca team. Guest access provides a simplified search interface to retrieve only basic information such as compound IDs and related 2D or 3D chemical structures. Moreover, some compounds can be hidden to Guest users according to an owner's decision. In contrast, registered users have full access to all of the Chemotheca data including the permission to upload new compounds and/or update experimental/theoretical data (e.g., activities against new targets tested) related to already stored compounds. In order to facilitate scientific collaborations, all available data are connected to the corresponding owner's email address (available for registered users only). The Chemotheca web site is accessible at http://chemotheca.unicz. it.
Phase II Study of Docetaxel in Combination with Everolimus for Second- or Third-Line Therapy of Advanced Non–Small-Cell Lung Cancer

We conducted a phase II study of docetaxel in combination with everolimus, a mammalian target of rapamycin (mTOR) inhibitor, for salvage therapy of advanced non–small-cell lung cancer (NSCLC) based on promising preclinical and early-phase clinical data. Patients with advanced-stage NSCLC treated with one or two previous systemic therapy regimens were given docetaxel (60 mg/m2) and everolimus (5 mg orally once daily on days 1–19) every 3 weeks. Archived tumor specimens were evaluated for markers of mTOR pathway activation (total and phosphorylated mTOR, Akt, S6, eIF4e, and 4EBP1). Twenty-eight patients were enrolled (median age: 62 years; male: 13; Caucasians: 19; adenocarcinoma: 20; performance status 0, 3; performance status 1, 23; 1 previous regimen, 16). A median of 3.5 cycles of therapy was administered. Two patients experienced partial response and 15 had stable disease (clinical benefit rate, 70%). The 6-month progression-free survival rate was 5%, and the median overall survival was 9.6 months. Low pAkt expression correlated with clinical benefit rate (p = 0.01) but not with progression-free survival or overall survival. The combination of everolimus and docetaxel was tolerated well, but the efficacy was relatively modest in an unselected population of patients with NSCLC.
Effect of Larval Nutrition on Maternal mRNA Contribution to the Drosophila Egg

Embryonic development begins under the control of maternal gene products, mRNAs and proteins that the mother deposits into the egg; the zygotic genome is activated some time later. Maternal control of early development is conserved across metazoans. Gene products contributed by mothers are critical to many early developmental processes, and set up trajectories for the rest of development. Maternal deposition of these factors is an often-overlooked aspect of parental investment. If the mother experiences challenging environmental conditions, such as poor nutrition, previous studies in Drosophila melanogaster have demonstrated a plastic response wherein these mothers may produce larger eggs to buffer the offspring against the same difficult environment. This additional investment can produce offspring that are more fit in the challenging environment. With this study, we ask whether D. melanogaster mothers who experience poor nutrition during their own development change their gene product contribution to the egg. We perform mRNA-Seq on eggs at a stage where all mRNAs are maternally derived, from mothers with different degrees of nutritional limitation. We find that nutritional limitation produces similar transcript changes at all degrees of limitation tested. Genes that have lower transcript abundance in nutritionally limited mothers are those involved in translation, which is likely one of the most energetically costly processes occurring in the early embryo. We find an increase in transcripts for transport and localization of macromolecules, and for the electron transport chain. The eggs produced by nutrition-limited mothers show a plastic response in mRNA deposition, which may better prepare the future embryo for development in a nutrition-limited environment.
The transcription factor FOXL 2 in ovarian function and dysfunction

The Blepharophimosis Ptosis Epicanthus-inversus Syndrome is a genetic disease characterized by complex eyelid malformations often associated with premature ovarian failure (POF). BPES is basically an autosomal dominant disease, due to mutations in the FOXL2 gene, which encodes a forkhead transcription factor. More than one hundred mutations of FOXL2 have been described to date. In agreement with the BPES phenotype, FOXL2 is expressed (though not exclusively) in the developing eyelids and in fetal and adult ovaries. Two mouse knock-out models have been produced. They recapitulate the BPES phenotype and have provided insights into the pathology. Loss-of-function mutations in FOXL2 are predicted to lead to BPES and POF, while hypomorphic mutations might lead to BPES without ovarian dysfunction. However, exceptions to the genotype-phenotype correlation have been described. To better understand the pathogenic effect of these mutations it is crucial to study the normal regulation of FOXL2 and its targets. We briefly address these aspects in this review and hope that basic research around FOXL2 will eventually lead to uncover new therapeutic avenues.
Recognition, use and perceptions of JUUL among youth and young adults

In recent years, use of electronic nicotine delivery systems (ENDS) has drastically increased, exceeding the prevalence of combustible tobacco use among youth in the USA.1 ENDS products are heavily marketed on television, radio and the internet, in print and at the point-of-sale,2–5 using strategies that may appeal to youth.6 Recent national data suggest exposure to ENDS marketing may be associated with increased use of the products among young people.5 7 Of public health concern are the findings suggesting negative health consequences associated with ENDS use and associations between ENDS use and future combustible tobacco use. Additionally, ENDS use is substantially higher among youth, a group for whom nicotine exposure is particularly harmful, compared with adults.1 A novel ENDS product, JUUL, was developed by PAX Labs and represents one of the latest efforts to innovate within the ENDS market. The slim, high-tech devices are charged through USB ports and use nicotine cartridges, or ‘pods’, that come in a variety of flavours. Through novel product design and use of organic nicotine salts extracted from tobacco leaves, rather than the ‘freebase formulations’8 of nicotine used in other ENDS, PAX Labs claims JUUL provides a nicotine concentration comparable with a traditional cigarette and delivers nicotine 1.25–2.7 times faster than competing ENDS. Since its introduction in early 2015, JUUL has experienced tremendous growth in market share. As of 24 February 2018, JUUL represented an astonishing 49.6% …
Hyperparameter-selection for sparse regression: A probablistic approach

The choice of hyperparameter(s) notably affects the support recovery in LASSO-like sparse regression problems, acting as an implicit model order selection. Parameters are typically selected using cross-validation or various ad hoc approaches. These often overestimates the resulting model order, aiming to minimize the prediction error rather than maximizing the support recovery. In this work, we propose a probabilistic approach to selecting hyperparameters in order to maximize the support recovery, quantifying the type I error (false positive rate) using extreme value analysis, such that the regularization level is selected as an appropriate quantile. By instead solving the scaled LASSO problem, the proposed choice of hyperparameter becomes almost independent of the noise variance. Simulation examples illustrate how the proposed method outperforms both cross-validation and the Bayesian Information Criterion in terms of computational complexity and support recovery.
Relation of Aortic Stiffness to Left Ventricular Remodeling in Younger Adults With Type 2 Diabetes

Individuals with type 2 diabetes have a three- to fivefold increased risk of developing heart failure. Diabetic cardiomyopathy is typified by left ventricular (LV) concentric remodeling, which is a recognized predictor of adverse cardiovascular events. Although the mechanisms underlying LV remodeling in type 2 diabetes are unclear, progressive aortic stiffening may be a key determinant. The aim of this study was to assess the relationship between aortic stiffness and LV geometry in younger adults with type 2 diabetes, using multiparametric cardiovascular MRI. We prospectively recruited 80 adults (aged 18–65 years) with type 2 diabetes and no cardiovascular disease and 20 age- and sex-matched healthy control subjects. All subjects underwent comprehensive bio-anthropometric assessment and cardiac MRI, including measurement of aortic stiffness by aortic distensibility (AD). Type 2 diabetes was associated with increased LV mass, concentric LV remodeling, and lower AD compared with control subjects. On multivariable linear regression, AD was independently associated with concentric LV remodeling in type 2 diabetes. Aortic stiffness may therefore be a potential therapeutic target to prevent the development of heart failure in type 2 diabetes.
Neurocognitive development and behaviour in school-aged children after surgery for univentricular or biventricular congenital heart disease.

OBJECTIVES To assess the long-term neuropsychological and behavioural profile of school-aged children who were treated for univentricular heart (UVH) conditions or biventricular heart defect (BiVH) in infancy in a cross-sectional study design. METHODS Sixty-three patients, 17 UVH (13 males, 4 females) and 46 BiVH (19 males, 27 females), were assessed at a mean age of 9.1 years (2.2 years) with an intelligence and neuropsychological test battery. Results were compared between subgroups (UVH, BiVH and a healthy control group). Associations between cognitive outcome, medical and socio-demographic factors were explored. Parents completed the Child Behavior Checklist (CBCL). RESULTS Mean intelligence and neuropsychological scores were found within normal ranges for all diagnostic groups. Significant differences between UVH patients and controls emerged on auditory sustained and alternating attention, fine motor skills, visuospatial information processing, and to a lesser extent, memory performance. Parents of UVH patients reported more externalizing problems and school problems. Patient groups did not differ on neuropsychological outcome measures, nor on behavioural problems as rated by parents. CONCLUSIONS After Fontan completion, patients at school age display intelligence scores within normal population-based ranges. However, they were found at risk for subtle shortcomings in attention, fine motor skills, visuospatial information processing and externalizing behaviour problems. Considerations pertaining to neurobehavioural outcome in school-aged children are discussed.
An Efficient and Stabilization of Lithomargic Soil Using alkali activated Fly ash

Due to cohesiveness property in expansive soil, it becameweak and good for foundation or pavement subgrade. Soil Stabilization is one of the most important aspects ofthe construction industry, which is used widely in foundation and road pavement constructions; this is because suchstabilization improves Geotechnical properties of the soil, such as volume stability, strength and durability.Alkali activated flyashes are the cement for the future. The alkali activation of wastematerials is a chemical process that allows the user to transform glassy structures (partially ortotally amorphous and/or metastable) into very compact well-cemented composites.The present study focuses on investigations on the engineering properties of Lithomargicsoils. Attempts are being made to investigate the study on Stabilization of Lithomargic soil (silty-soil) by using alkali activated polymers combined with Fly-ash.