Miracle-dz/UniFAR-FTUs huggingface dataset:
Laparoscopic Radical Trachelectomy after Neoadjuvant Chemotherapy for Fertility Preservation in Early-Stage Bulky Cervical Cancer: A Case Report and Literature Review

Management of early-stage cervical cancer (CC) in young women often faces challenges to preserve fertility, as well as to achieve an adequate oncological outcome. Although existing evidence supports a fertility-sparing treatment in the case of tumors <2 cm in diameter, the approach is less clear in bulky early-stage CC. In addition, the outcomes of radical trachelectomy performed by minimally invasive techniques are also highly debatable. Highlighting the high incidences of young women with early-stage CC, the lack of sufficient data raises considerable hindrances towards the proper counseling of this vulnerable patient group. In this report, a case of a young woman with bulky early-stage CC with a strong desire to preserve fertility is presented. A satisfactory oncological outcome was achieved after neoadjuvant chemotherapy followed by laparoscopic radical trachelectomy. Ongoing prospective trials are expected to provide stronger evidence on this topic.
An Integrated Circuit for Galvanostatic Electrodeposition of on-chip Electrochemical Sensors

This paper presents the design of an integrated circuit (IC) for (i) galvanostatic deposition of sensor layers on the on-chip pads, which serve as the sensor's base layer, and (ii) amperometric readout of electrochemical sensors. The system consists of three main circuit blocks: the electrochemical cell including a $4\times 4$ electrode array, two Beta-multiplier based current generators and one pA-size current generator for galvanostatic electrodeposition, and a switch-capacitor based amperometric readout circuit for sensor current measurement. The circuits are designed and simulated in a 180-nm CMOS process. The three current reference circuits generate a stable current from 7.2 pA to $88\ \mu\mathrm{A}$ with low process, power supply voltage and temperature (PVT) sensitivity. The pA-size current generator has a temperature coefficient of 517.8 ppm/°C on average (across corners) in the range of 0 to 60°C. The line regulation is 4.4 %/V over a supply voltage range of 0.8-3 V. The feasibility of galvanostatic deposition on on-chip pads is validated by applying a fixed current of 300 nA to electrochemically deposit a gold layer on top of electrodes with nickel/zinc as the adhesive layer for gold. Successful deposition of gold was confirmed using optical microscope images of the on-chip electrodes.
Path Planning in Urban Environment Based on Traffic Condition Perception and Traffic Light Status

Vehicle path planning problems have been studied for decades. The existing path planning methods are suitable for simple objectives. However, for complex tasks such as planning paths for vehicles considering the effects of pedestrians, traffic lights, etc., it is difficult to design a reasonable cost function for the deterministic algorithm or a reasonable heuristic function for the heuristic algorithm. In this paper, we proposes a path planning model based on traffic light status and traffic condition awareness. When a vehicle arrives at a new road section, it senses the traffic light status, distribution and vehicle positions in the road network on each road section through V2V and V2I communication, and based on this information, we use an A2C-based deep reinforcement learning method to dynamically plan the shortest path for the vehicle in real time. Experiments show that the proposed method works effectively in terms of saving on driving time and waiting time to reach any destinations, compared to the existing solutions.
Gene variants previously associated with reduced soft-tissue injury risk: Part 2 – Polygenic associations with elite status in Rugby

ABSTRACT Part 1 of this genetic association series highlighted several genetic variants independently associated with elite status in rugby. However, it is highly likely that the genetic influence on elite status is polygenic due to the interaction of multiple genes. Therefore, the aim of the present study was to investigate whether polygenic profiles of elite rugby athletes differed from non-athletes utilising 13 genetic polymorphisms previously associated with tendon/ligament injury. Total genotype score (TGS) was calculated and multifactor dimensionality reduction (MDR) was used to calculate SNP-SNP epistasis interactions. Based on our elite rugby data from Part 1, mean TGS was significantly higher in elite rugby athletes (52.1 ± 10.7) than non-athletes (48.7 ± 10.8). There were more elite rugby athletes (54%) within the upper TGS quartile, and fewer (46%) within the lower quartile, compared to non-athletes (31% and 69%, respectively; P = 5·10−5), and the TGS was able to distinguish between elite rugby athletes and non-athletes (area under the curve = 0.59; 95% confidence interval 0.55-0.63; P = 9·10−7). Furthermore, MDR identified a three-SNP model of COL5A1 rs12722, COL5A1 rs3196378 and MIR608 rs4919510 that was best able to predict elite athlete status, with a greater frequency of the CC-CC-CC genotype combination in elite rugby athletes (9.8%) than non-athletes (5.3%). We propose that elite rugby athletes possess “preferable” musculoskeletal soft-tissue injury-associated polygenic profiles that have helped them achieve success in the high injury risk environment of rugby. These data may, in future, have implications for the individual management of musculoskeletal soft-tissue injury. Highlights Elite rugby athletes have preferable polygenic profiles to non-athletes in terms of genetic variants previously associated with musculoskeletal soft-tissue injury. The total genotype score was able to distinguish between elite rugby athletes and non-athletes. COL5A1 rs12722, COL5A1 rs3196378 and MIR608 rs4919510 produced the best model for predicting elite athlete status. We propose that elite rugby athletes may have an inherited advantage to achieving elite status due to an increased resistance to soft-tissue injury.
Linolenic Acid-Derived Oxylipins Inhibit Aflatoxin Biosynthesis in Aspergillus flavus through Activation of Imizoquin Biosynthesis

Oxylipins play important signaling roles in aflatoxin (AF) biosynthesis in Aspergillus flavus. We previously showed that exogenous supply of autoxidated linolenic acid (AL) inhibited AF biosynthesis in A. flavus via oxylipins, but the molecular mechanism is still unknown. Here, we performed multiomics analyses of A. flavus grown in media with or without AL. Targeted metabolite analyses and quantitative reverse transcription (qRT)-polymerase chain reaction (PCR) showed that the imizoquin (IMQ) biosynthetic pathway was distinctly upregulated in the presence of AL. 13C-glucose labeling confirmed in parallel that the tricarboxylic acid cycle was also enhanced by AL, consistent with observed increases in mycelial growth. Moreover, we integrated thermal proteome profiling and molecular dynamics simulations to identify a potential receptor of AL; AL was found to interact with a transporter (ImqJ) located in the IMQ gene cluster, primarily through hydrophobic interactions. Further analyses of strains with an IMQ pathway transcription factor overexpressed or knocked out confirmed that this pathway was critical for AL-mediated inhibition of AF biosynthesis. Comparison of 22 assembled A. flavus and Aspergillus oryzae genomes showed that genes involved in the IMQ pathway were positively selected in A. oryzae. Taken together, the results of our study provide novel insights into oxylipin-mediated regulation of AF biosynthesis and suggest potential methods for preventing AF contamination of crops.
Between mneme and anamnesis: on the memory and forgetting of the Roma Holocaust

ABSTRACT The article argues that what is usually called ‘Roma memory of the Holocaust’ needs to be differentiated into four types, depending on the combination of two modes (mneme and anamnesis) and two genealogies of memory (bottom-up and top-down). The first type is memory unconsciously encoded in culture; the second emerges due to the unblocking of memories by external factors; the third refers to the construction of memories by the Roma movement; and the fourth accounts for individual management of memory. These types correspond with four different aspects of Roma identity: cultural (substance), social (relation), historical (process), and individual (choice).
Operating Performance Assessment Based on Semi-Supervised Cluster Generative Adversarial Networks for Gold Flotation Process

Operating performance assessment of gold flotation process plays an important role in improving the metallurgical performances and pursues the best comprehensive economic benefits. The appearance of froth is a good indicator of flotation performance; however, labeling the data is costly. To assess the operational performance of flotation process with a small amount of labeled data, this study proposes a semi-supervised cluster generative adversarial network (SSClusterGAN). First, latent variables are sampled from one-hot encoded variables and continuous normal distribution variables. While projecting all data into the latent variable space, the specific types of clustering in the latent space is realized by controlling the type of distribution of the learned latent codes, so that the training objectives of labeled data and unlabeled data are consistent. Then, by adapting the generative adversarial networks (GANs) framework, a pair of stacked discriminators are used to learn the conditional distribution of attributes for labeled and unlabeled data, respectively. In addition, using semi-supervised learning (SSL) as the basic learning technology, the high-confidence pseudo-labels obtained by training with unlabeled data are combined with the labeled training data to increase the training samples and effectively improve the accuracy of the model. Finally, the method was applied to the gold flotation process. The experimental results show that the method effectively utilizes unlabeled samples to expand the labeled dataset, combines the advantages of SSL and GAN, obtains accurate assessment results, and effectively improves the comprehensive economic benefits of the gold flotation process.
Neutron production in ultraintense laser interactions with carbon-deuterated plasma at intensities of 1018 W cm−2

Wide-range neutron energy spectra that are produced when an ultraintense laser with an intensity of 3 × 1018 W cm−2 is focused on a CD2 target have been studied. The experimentally observed spectra and numerically calculated ones, by a three-dimensional Monte Carlo code, indicate that the energy range of the emitted neutrons is larger than that of the D(d,n)3He reaction. The reactions that can participate in neutron production and their relative importance have been analysed. An explanation for the measured spectra is introduced by taking into account the 12C(d,n)13N and D(12c,n)13N reactions. These reactions strongly participate in neutron production due to their high cross sections. Moreover, the neutrons from these reactions will overlap the neutrons from the D(d,n)3He reaction, including the 2.45 MeV neutrons, with increasing energy of the accelerated ions under higher irradiances.
Advances in the Treatment of Partial-Thickness Cartilage Defect

Abstract Partial-thickness cartilage defects (PTCDs) of the articular surface is the most common problem in cartilage degeneration, and also one of the main pathogenesis of osteoarthritis (OA). Due to the lack of a clear diagnosis, the symptoms are often more severe when full-thickness cartilage defect (FTCDs) is present. In contrast to FTCDs and osteochondral defects (OCDs), PTCDs does not injure the subchondral bone, there is no blood supply and bone marrow exudation, and the nearby microenvironment is unsuitable for stem cells adhesion, which completely loses the ability of self-repair. Some clinical studies have shown that partial-thickness cartilage defects is as harmful as full-thickness cartilage defects. Due to the poor effect of conservative treatment, the destructive surgical treatment is not suitable for the treatment of partial-thickness cartilage defects, and the current tissue engineering strategies are not effective, so it is urgent to develop novel strategies or treatment methods to repair PTCDs. In recent years, with the interdisciplinary development of bioscience, mechanics, material science and engineering, many discoveries have been made in the repair of PTCDs. This article reviews the current status and research progress in the treatment of PTCDs from the aspects of diagnosis and modeling of PTCDs, drug therapy, tissue transplantation repair technology and tissue engineering (“bottom-up”).
Anti-Correlated Myelin-Sensitive MRI Levels in Humans Consistent with a Subcortical to Sensorimotor Regulatory Process—Multi-Cohort Multi-Modal Evidence

Differential axonal myelination synchronises signalling over different axon lengths. The consequences of myelination processes described at the cellular level for the regulation of myelination at the macroscopic level are unknown. We analysed multiple cohorts of myelin-sensitive brain MRI. Our aim was to (i) confirm a previous report of anti-correlation between myelination in subcortical and sensorimotor areas in healthy subjects, (ii) and thereby test our hypothesis for a regulatory interaction between them. We analysed nine image-sets across three different human cohorts using six MRI modalities. Each image-set contained healthy controls (HC) and ME/CFS subjects. Subcortical and Sensorimotor regions of interest (ROI) were optimised for the detection of anti-correlations and the same ROIs were used to test the HC in all image-sets. For each cohort, median MRI values were computed in both regions for each subject and their correlation across the cohort was computed. We confirmed negative correlations in healthy controls between subcortical and sensorimotor regions in six image-sets: three T1wSE (p = 5 × 10−8, 5 × 10−7, 0.002), T2wSE (p =2 × 10−6), MTC (p = 0.01), and WM volume (p = 0.02). T1/T2 was the exception with a positive correlation (p = 0.01). This myelin regulation study is novel in several aspects: human subjects, cross-sectional design, ROI optimization, spin-echo MRI and reproducible across multiple independent image-sets. In multiple independent image-sets we confirmed an anti-correlation between subcortical and sensorimotor myelination which supports a previously unreported regulatory interaction. The subcortical region contained the brain’s primary regulatory nuclei. We suggest a mechanism has evolved whereby relatively low subcortical myelination in an individual is compensated by upregulated sensorimotor myelination to maintain adequate sensorimotor performance.
Influences of B-site Cations on Intrinsic Dielectric Properties of Ba(B′1/3B′′2/3)O3 Materials

Effects of B-site cations on polar phonon frequencies, mode effective charges, and lattice dielectric response of 1:2 ordered Ba(Mg1/3Ta2/3)O3, Ba(Mg1/3Nb2/3)O3, and Ba(Zn1/3Nb2/3)O3 microwave dielectrics are studied using first-principles calculations. The calculated optical phonon frequencies and the average dielectric constants are found to be in excellent agreement with experiments. Replacing Ta (Mg) with Nb (Zn) is found to significantly affect frequency, oscillator strength, and mode effective charges of the dominant polar phonons. Dielectric contributions from O anions are dominant and strongly B-site dependent. Furthermore, we demonstrate that the greater the dielectric contribution from O anions, the smaller the measured microwave Q × f-factor.
Multi-channel Fourier domain OCT system with superior lateral resolution for biomedical applications

The lateral resolution of Fourier domain optical coherence tomography (FD-OCT) systems is limited by the depth of focus that can be achieved over the desired imaging depth at the chosen wavelength. Various solutions have been proposed such as Bessel beams and computational methods; however these suffer from various practical drawbacks. We present a novel optical set-up involving multiple optical channels that does not suffer from these drawbacks and delivers at least double the resolution of a single beam system. The theory of this approach is discussed, also the realisation in a practical laboratory system, measurement results and initial application in assessing oesophageal cancers and pre-cancers.
Experiments with synthetic spin-orbit coupling and spin transport in Bose Einstein Condensates

Niffenegger, Robert J. Ph.D., Purdue University, May 2015. Experiments with Synthetic Spin-Orbit Coupling and Spin Transport in Bose Einstein Condensates . Major Professor: Yong P. Chen. In this thesis I will describe my experiments to study spin transport of spin Bose Einstein Condensates (BECs) with synthetic spin-orbit coupling. First I will describe procedures used to reproduce previous experiments with synthetic gauge fields in Bose-Einstein Condensates, from constant vector potentials to synthetic electric fields and synthetic spin-orbit coupling as well as all of the necessary calibration experiments. Next I will describe new experiments measuring spin transport induced by synthetic spin-dependent electric fields in spin-orbit coupled Bose-Einstein Condensates (BECs). The one dimensional (1D) spin-orbit coupling (SOC) is created with counter propagating Raman lasers which couple hyperfine sub-levels and momentum states of Rb, allowing us to engineer spin dependent vector potentials. Quickly lowering the Raman laser intensity, decreases the spin-orbit Raman coupling strength (Ω), separates the spin vector potentials and applies opposite synthetic electric fields to the two dressed spin BECs. We allow them to oscillate in opposite directions within the optical trap (exhibiting a spin dipole mode) and measure the time evolution of their momentum and density after time-of-flight (TOF). The damping of the oscillations as the spin BECs collide is found to drastically increase for larger final Raman coupling. Over longer time scales, the bare spins’ oscillations damp and thermalize. However, with Raman coupling, dressed spins’ oscillations are overdamped and accompanied by rich excitations in the BEC but less thermalization.
Performance of an energy-compensated three-dimensional atom probe

A wide acceptance angle first-order reflectron lens has been incorporated into a three-dimensional atom probe (3DAP) to provide improved mass resolution. This new 3DAP instrument is capable of resolving isotopes in the mass spectrum, with resolutions better than m/Δm=500 full width at half maximum and 250 full width at 10% maximum. However, use of a reflectron for energy compensation within an imaging system means that improvements in mass resolution result in degradation of the spatial resolution. This article addresses the detailed design of the energy compensated 3DAP, and the minimization and compensation of chromatic aberrations in the imaging performance of the instrument. Some applications of the new instrument are included to illustrate its capabilities in the atomic-scale analysis of engineering alloys.
Surfaces with constant Chebyshev angle

In this paper we consider surfaces with negative Gaussian curvature parametrized by a generalized Chebyshev net with constant Chebyshev angle in the Euclidean 3-space. We characterize these surfaces in terms of a meromorphic function which satisﬁes a certain differential equation. Moreover, we show that these surfaces have the geometric property that the asymptotic lines have the same sign of geodesic curvature. As an application we obtain for each constant Chebyshev angle a four-parameter family of complete surfaces.
Item Parameter Estimation for a Continuous Response Model Using an EM Algorithm

An item parameter estimation procedure is cedure was pro-developed using an EM algorithm for Samejima's (1973) continuous item response model. The potential usefulness of this model is examined, including the density function and the practical meaning of the item parameters and statistical properties of the model. The expected a posteriori and maximum likelihood estimates of the person (0) parameters and their associated standard errors are also described. The item parameter estimation pro grammed and evaluated using simulated data. The results show that the estimation procedure performs well in estimating item and 0 parameters. These estimation procedures should permit the application of the continuous response model to many measurement problems.
Determinants Of Turnover Intention With Organizational Commitment As Moderating

This study aims to determine the influence of self-efficacy, perceived organizational support, and Islamic work ethics on turnover intention with organizational commitment as moderation at PT. X Semarang. This research is quantitative research using primary data sources. The population in this study found 278 employees. The sampling technique used is purposive sampling, while the sample size is calculated using the Slovin formula so that the number of samples is 75 employees. This research uses multiple regression analysis with the moderated regression analysis (MRA) test. The results of this study are that self-efficacy (SE) positively and significantly affects turnover intention (TI). Perceived organizational support (POS) negatively and significantly affects TI. Islamic work ethic (IWE) negatively and significantly affects TI. Organizational commitment (OC) cannot moderate SE on TI. OC cannot moderate POS on TI. OC cannot moderate IWE on TI. This study provides a new perspective, namely from the employee’s point of view psychologically, the company can be used as a reference to reduce the turnover rate at PT. X Semarang. Specifically, regarding what factors need to be addressed so that the employee turnover rate can be reduced, this study can also reduce turnover rates by increasing perceived organizational support and the employee’s Islamic work ethic.
Learn to Grasp Via Intention Discovery and Its Application to Challenging Clutter

Humans excel in grasping objects through diverse and robust policies, many of which are so probabilistically rare that exploration-based learning methods hardly observe and learn. Inspired by the human learning process, we propose a method to extract and exploit latent intents from demonstrations, and then learn diverse and robust grasping policies through self-exploration. The resulting policy can grasp challenging objects in various environments with an off-the-shelf parallel gripper. The key component is a learned intention estimator, which maps gripper pose and visual sensory to a set of sub-intents covering important phases of the grasping movement. Sub-intents can be used to build an intrinsic reward to guide policy learning. The learned policy demonstrates remarkable zero-shot generalization from simulation to the real world while retaining its robustness against states that have never been encountered during training, novel objects such as protractors and user manuals, and environments such as the cluttered conveyor.
An Unconditionally Secured Privacy-Preserving Authentication Scheme for Smart Metering Infrastructure in Smart Grid

Industry 4.0 allows faster data accessibility, improved performance, fault identification, and remote control of machines within any smart factory. Due to the massive generation of delay-sensitive data, this system demands a robust security mechanism against security threats. In order to mitigate such potential attacks and provide security-free services, this article proposes an edge-based conditional privacy-preserving authentication scheme based on quantum key distribution protocol for secure authentication and secure communication within smart grid infrastructure. Apart from guaranteeing security against threats such as node impersonation, message tampering, and repudiation, the scheme also defends man-in-the-middle attacks, replay attacks, etc. We validate the proposed protocol through a simulation study. The result indicates that it performs reasonably well and enables unconditional security for the data exchanged between entities of smart grid infrastructure.