Miracle-dz/UniFAR-FTUs huggingface dataset:
Beliefs of Ambulatory Care Physicians about Accuracy of Patient Medication Records and Technology‐Enhanced Solutions to Improve Accuracy

&NA; The continuing problem of inaccurate medication records and resultant harm from medication errors has prompted the Institute of Medicine and others to encourage information technology (IT) solutions to improve medication list accuracy. There are few studies on how ambulatory care documentation contributes to medication list inaccuracies and medication reconciliation failures. To address medication reconciliation issues in ambulatory care, office‐based physicians in a region with a high adoption rate for electronic medical records (EMRs) were surveyed about current reconciliation practices, the need for redesigning reconciliation processes, and acceptable IT solutions for improving availability of medication information. Physicians selected from a list of potential IT platforms that would create a single reconciled record of prescription medications, nonprescription medications, and supplements accessible wherever patients go. The two most popular platforms were either an aggregated list within existing EMRs accessible by inpatient and outpatient providers regardless of their EMR system, or a web‐based repository that was not integrated into an EMR. Respondents felt that implementation of such platforms would not require major changes to clinical workflow, perhaps due to the region's existing familiarity with health IT. Leveraging community acceptance of health IT could result in rapid implementation of universally accessible medication list platforms.
High-resolution FMCW millimeter-wave and terahertz thickness measurements

We have adapted the FMCW radar technique to perform high-resolution thickness measurements within the millimeter-wave and terahertz frequency domain. High signal modulation bandwidths of several 10 GHz conform to millimeter resolution limits as well as micrometer accuracies. However, for our target application — the thickness measurement of single- and multi-layer plastics such as tube walls — the adapted approach for FMCW radar distance measurements is insufficient. Thick layers restrict the penetration depth of high frequency signals. Therefore, operation frequencies in the millimeter-wave or lower terahertz regime are required, which provide reduced modulation bandwidths and hence limit the resolution in the order of approximately one to several millimeters. Simultaneously, fine layers have to be separated. In this contribution, we present a correlation approach to overcome the Rayleigh resolution limit including first promising results for single and multi-layer structures.
Revisiting Shared Cache Contention Problems: A Practical Hardware-Software Cooperative Approach

SUMMARY Although shared caches allow the dynamic allocation of limited cache capacity among cores, traditional LRU replacement policies often cannot prevent negative interference among cores. To address the contention problem in shared caches, cache partitioning and application scheduling techniques have been extensively studied. Partitioning ex- plicitly determines cache capacity for each core to maximize the overall throughput. On the other hand, application scheduling by operating sys- tems groups the least interfering applications for each shared cache, when multiple shared caches exist in systems. Although application scheduling can mitigate the contention problem without any extra hardware support, its e ﬀ ect can be limited for some severe contentions. This paper proposes a low cost solution, based on application scheduling with a simple cache insertion control. Instead of using a full hardware-based cache partitioning mechanism, the proposed technique mostly relies on application scheduling. It selectively uses LRU insertion to the shared caches, which can be added with negligible hardware changes from the current commercial processor designs. For the completeness of cache interference evaluation, this paper examines all possible mixes from a set of applications, instead of using a just few selected mixes. The evaluation shows that the proposed technique can mitigate the cache contention problem e ﬀ ectively, close to the ideal scheduling and partitioning.
Activation of interleukin-6 gene expression through the NF-kappa B transcription factor

The promoter region of the interleukin-6 (IL-6) gene has a putative NF-kappa B-binding site. We found that a fragment of the IL-6 promoter containing the site specifically binds highly purified NF-kappa B protein and the NF-kappa B protein in nuclear extracts of phorbol ester-induced Jurkat cells. Mutations of the NF-kappa B site abolished complex formation with both purified NF-kappa B and the nuclear extract protein. Transient expression of chloramphenicol acetyltransferase (CAT) plasmids containing the IL-6 promoter revealed very little activity of the promoter in U-937 monocytic cells and in HeLa cells before stimulation. However, stimulation of U-937 and HeLa cells by inducers of NF-kappa B led to a dramatic increase in CAT activity. Mutations in the NF-kappa B-binding site abolished inducibility of IL-6 promoter-cat constructs in U-937 cells by lipopolysaccharide, tumor necrosis factor alpha, the double-stranded RNA poly(IC), or phytohemagglutinin and in HeLa cells by tumor necrosis factor alpha and drastically reduced but did not completely eliminate inducibility in HeLa cells stimulated by double-stranded RNA poly(IC) or phorbol 12-myristate 13-acetate. These results suggest that NF-kappa B is an important mediator for activation of the IL-6 gene by a variety of IL-6 inducers in both U-937 and HeLa cells and that alternative inducible enhancer elements contribute in a cell-specific manner to IL-6 gene induction. Because NF-kappa B is involved in the control of a variety of genes activated upon inflammation, NF-kappa B may play a central role in the inflammatory response to infection and tissue injury.
Fertility among immigrant women: new data a new approach.

The contribution made by migration to French population dynamics is not confined to arrivals: immigrants have children after they arrive in France. These children by definition do not appear in the net migration count but in the rate of natural increase. How do we account for them in estimating the share of the French birth rate due to immigration? There are three ways of doing so corresponding to three distinct questions. First what is the proportion of children born in France to at least one immigrant parent? Second how does immigrant fertility compare with that of the countries of origin and destination? Third what would be the level of fertility in France without immigration? (excerpt)
Class Conditional Nearest Neighbor and Large Margin Instance Selection

—The one nearest neighbor ( 1-NN ) rule uses instance proximity followed by class labeling information for classifying new instances. This paper presents a framework for studying properties of the training set related to proximity and labeling information, in order to improve the performance of the 1-NN rule. To this aim, a so-called class conditional nearest neighbor ( c.c.n.n. ) relation is introduced, consisting of those pairs of training instances ( a, b ) such that b is the nearest neighbor of a among those instances (excluded a ) in one of the classes of the training set. A graph-based representation of c.c. n.n. is used for a comparative analysis of c.c. n.n. and of other interesting proximity-based concepts. In particular, a scoring function on instances is introduced, which measures the effect of removing one instance on the hypothesis-margin of other instances. This scoring function is employed to develop an effective large margin instance selection algorithm, which is empirically demonstrated to improve storage and accuracy performance of the 1-NN rule on artiﬁcial and real-life data sets.
Exploring the Influence of Identifier Names on Code Quality: An Empirical Study

Given the importance of identifier names and the value of naming conventions to program comprehension, we speculated in previous work whether a connection exists between the quality of identifier names and software quality. We found that flawed identifiers in Java classes were associated with source code found to be of low quality by static analysis. This paper extends that work in three directions. First, we show that the association also holds at the finer granularity level of Java methods. This in turn makes it possible to, secondly, apply existing method-level quality and readability metrics, and see that flawed identifiers still impact on this richer notion of code quality and comprehension. Third, we check whether the association can be used in a practical way. We adopt techniques used to evaluate medical diagnostic tests in order to identify which particular identifier naming flaws could be used as a light-weight diagnostic of potentially problematic Java source code for maintenance.
SYNTHESIS AND PROCESSING OF THE SINGING VOICE

As soon as the beginning of the 60Õs, the singing voice have been synthesized by computer. Since these first experiments, the musical and natural quality of singing voice synthesis has largely improved and high quality commercial applications can be envisioned for a near future. This talk gives an overview of synthesis methods, control strategies and research in this field. Future challenges include synthesizer models improvements, automatic estimation of model parameter values from recordings, learning techniques for automatic rule construction and gaining a better understanding of the technical, acoustical and interpretive aspects of the singing voice
Exploiting Computational Redundancy for Efficient Recovery from Soft Errors in Sensor Nodes

Most existing techniques for the design and implementation of fault tolerance use resource redundancy. As such, due to scarcity of resources, it is difficult to directly apply them for adding fault tolerance to sensor nodes in Wireless Sensor Networks (WSNs). Thus, it is desirable to develop techniques that implement fault tolerance under the constraints of memory and processing power of sensor nodes. We present a novel method for designing recovery from transient faults that cause nondeterministic bit-flips in the task queue of the scheduler of TinyOS, which is the operating system of choice for sensor nodes. Specifically, our approach exploits computational redundancy for the design of recovery instead of using resource redundancy. The presented fault-tolerant task queue recovers from bit-flips with significantly lower space/time overhead compared with the Error Correction Codes.
Salidroside Improves Behavioral and Histological Outcomes and Reduces Apoptosis via PI3K/Akt Signaling after Experimental Traumatic Brain Injury

Background Traumatic brain injury (TBI) induces a complex sequence of apopototic cascades that contribute to secondary tissue damage. The aim of this study was to investigate the effects of salidroside, a phenolic glycoside with potent anti-apoptotic properties, on behavioral and histological outcomes, brain edema, and apoptosis following experimental TBI and the possible involvement of the phosphoinositide 3-kinase/protein kinase B (PI3K)/Akt signaling pathway. Methodology/Principal Findings Mice subjected to controlled cortical impact injury received intraperitoneal salidroside (20, or 50 mg/kg) or vehicle injection 10 min after injury. Behavioral studies, histology analysis and brain water content assessment were performed. Levels of PI3K/Akt signaling-related molecules, apoptosis-related proteins, cytochrome C (CytoC), and Smac/DIABLO were also analyzed. LY294002, a PI3K inhibitor, was administered to examine the mechanism of protection. The protective effect of salidroside was also investigated in primary cultured neurons subjected to stretch injury. Treatment with 20 mg/kg salidroside_significantly improved functional recovery and reduced brain tissue damage up to post-injury day 28. Salidroside_also significantly reduced neuronal death, apoptosis, and brain edema at day 1. These changes were associated with significant decreases in cleaved caspase-3, CytoC, and Smac/DIABLO at days 1 and 3. Salidroside increased phosphorylation of Akt on Ser473 and the mitochondrial Bcl-2/Bax ratio at day 1, and enhanced phosphorylation of Akt on Thr308 at day 3. This beneficial effect was abolished by pre-injection of LY294002. Moreover, delayed administration of salidroside at 3 or 6 h post-injury reduced neuronal damage at day 1. Salidroside treatment also decreased neuronal vulnerability to stretch-induced injury in vitro. Conclusions/Significance Post-injury salidroside improved long-term behavioral and histological outcomes and reduced brain edema and apoptosis following TBI, at least partially via the PI3K/Akt signaling pathway.
Dynamic regulation of Nanog and stem cell-signaling pathways by Hoxa1 during early neuro-ectodermal differentiation of ES cells

Homeobox a1 (Hoxa1) is one of the most rapidly induced genes in ES cell differentiation and it is the earliest expressed Hox gene in the mouse embryo. In this study, we used genomic approaches to identify Hoxa1-bound regions during early stages of ES cell differentiation into the neuro-ectoderm. Within 2 h of retinoic acid treatment, Hoxa1 is rapidly recruited to target sites that are associated with genes involved in regulation of pluripotency, and these genes display early changes in expression. The pattern of occupancy of Hoxa1 is dynamic and changes over time. At 12 h of differentiation, many sites bound at 2 h are lost and a new cohort of bound regions appears. At both time points the genome-wide mapping reveals that there is significant co-occupancy of Nanog (Nanog homeobox) and Hoxa1 on many common target sites, and these are linked to genes in the pluripotential regulatory network. In addition to shared target genes, Hoxa1 binds to regulatory regions of Nanog, and conversely Nanog binds to a 3′ enhancer of Hoxa1. This finding provides evidence for direct cross-regulatory feedback between Hoxa1 and Nanog through a mechanism of mutual repression. Hoxa1 also binds to regulatory regions of Sox2 (sex-determining region Y box 2), Esrrb (estrogen-related receptor beta), and Myc, which underscores its key input into core components of the pluripotential regulatory network. We propose a model whereby direct inputs of Nanog and Hoxa1 on shared targets and mutual repression between Hoxa1 and the core pluripotency network provides a molecular mechanism that modulates the fine balance between the alternate states of pluripotency and differentiation.
Safety and clinical activity of a combination therapy comprising two antibody-based targeting agents for the treatment of non-Hodgkin lymphoma: results of a phase I/II study evaluating the immunoconjugate inotuzumab ozogamicin with rituximab.

PURPOSE Inotuzumab ozogamicin (INO) is an antibody-targeted chemotherapy agent composed of a humanized anti-CD22 antibody conjugated to calicheamicin, a potent cytotoxic agent. We performed a phase I/II study to determine the maximum-tolerated dose (MTD), safety, efficacy, and pharmacokinetics of INO plus rituximab (R-INO) for treatment of relapsed/refractory CD20(+)/CD22(+) B-cell non-Hodgkin lymphoma (NHL). PATIENTS AND METHODS A dose-escalation phase to determine the MTD of R-INO was followed by an expanded cohort to further evaluate the efficacy and safety at the MTD. Patients with relapsed follicular lymphoma (FL), relapsed diffuse large B-cell lymphoma (DLBCL), or refractory aggressive NHL received R-INO every 4 weeks for up to eight cycles. RESULTS In all, 118 patients received one or more cycles of R-INO (median, four cycles). Most common grade 3 to 4 adverse events were thrombocytopenia (31%) and neutropenia (22%). Common low-grade toxicities included hyperbilirubinemia (25%) and increased AST (36%). The MTD of INO in combination with rituximab (375 mg/m(2)) was confirmed to be the same as that for single-agent INO (1.8 mg/m(2)). Treatment at the MTD yielded objective response rates of 87%, 74%, and 20% for relapsed FL (n = 39), relapsed DLBCL (n = 42), and refractory aggressive NHL (n = 30), respectively. The 2-year progression-free survival (PFS) rate was 68% (median, not reached) for FL and 42% (median, 17.1 months) for relapsed DLBCL. CONCLUSION R-INO demonstrated high response rates and long PFS in patients with relapsed FL or DLBCL. This and the manageable toxicity profile suggest that R-INO may be a promising option for CD20(+)/CD22(+) B-cell NHL.
Outdoor Environments for People with Dementia

Introduction: Outdoor environments for people with dementia - Benyamin Schwarz & Susan Rodiek 2. Creating a therapeutic garden that works for people living with Alzheimer's - John Zeisel 3. Outdoor wandering parks for persons with dementia - Jiska Cohen-Mansfield 4. Housing and connection to nature for people with dementia: Findings from the INDEPENDENT Project - Grant Gibson, Garuth E. Chalfont, Pamela D. Clarke, Judith M. Torrington & Andrew J. Sixsmith 5. Restorative Dementia Gardens: Exploring how design may ameliorate attention fatigue - Keith Diaz Moore 6. The Garden-Model: An environmental tool for increasing the use of outdoor space by residents with dementia in long-term care facilities - Charlotte F. Grant & Jean D. Wineman 7. Effects of therapeutic gardens in special care units for people with dementia: Two case studies - Rebecca Ory Hernandez 8. Wholistic design in dementia care: Connection to nature with PLANET - Garuth E. Chalfont 9. Alzheimer's garden audit tool - Clare Cooper Marcus 10. Therapeutic effects of an outdoor activity program on nursing home residents with dementia - Bettye Rose Connell, Jon A. Sanford & Donna Lewis 11. Effects of increased time spent outdoors on individuals with dementia residing in nursing homes - Margaret Calkins & Joseph Szmerekovsky 12. Contact with outdoor greenery can support competence among people with dementia - Erja Rappe & Paivi Topo 13. Gardens for people with dementia: Increasing access to the natural environment for residents with Alzheimer's - Nancy J. Chapman, Teresia Hazen & Eunice Noell-Waggoner 14. Designing successful gardens and outdoor spaces for individuals with Alzheimer's disease - Elizabeth C. Brawley 15. Garden of the Family Life Center, Grand Rapids, Michigan - Clare Cooper Marcus
More effective power-gated circuit optimization with multi-bit retention registers

Applying retention registers is one of the most effective and efficient approaches to keep flip-flop states in power-gated circuits during the sleep mode. Instead of replacing each flip-flop in a power-gated circuit with a single-bit retention register (SBRR), recent research has shown that applying multi-bit retention registers (MBRRs) can effectively reduce the storage size, and hence save more chip area and leakage power. However, the previous work simply adopted greedy heuristics for power-gated circuit optimization with MBRRs, which first break feedback paths and then iteratively replace a flip-flop covering the maximum number of (k-1)-link paths with a k-bit retention register. Different from the previous work, this paper presents an even more effective approach based on integer-linear-programming (ILP) formulation with simultaneous consideration of all feedback paths. Experimental results show that the proposed approach can further reduce up to 46% storage size compared with the previous work.
Angiogenesis Inhibitor Vasohibin-1 Enhances Stress Resistance of Endothelial Cells via Induction of SOD2 and SIRT1

Vasohibin-1 (VASH1) is isolated as an endothelial cell (EC)-produced angiogenesis inhibitor. We questioned whether VASH1 plays any role besides angiogenesis inhibition, knocked-down or overexpressed VASH1 in ECs, and examined the changes of EC property. Knock-down of VASH1 induced premature senescence of ECs, and those ECs were easily killed by cellular stresses. In contrast, overexpression of VASH1 made ECs resistant to premature senescence and cell death caused by cellular stresses. The synthesis of VASH1 was regulated by HuR-mediated post-transcriptional regulation. We sought to define the underlying mechanism. VASH1 increased the expression of (superoxide dismutase 2) SOD2, an enzyme known to quench reactive oxygen species (ROS). Simultaneously, VASH1 augmented the synthesis of sirtuin 1 (SIRT1), an anti-aging protein, which improved stress tolerance. Paraquat generates ROS and causes organ damage when administered in vivo. More VASH1 (+/−) mice died due to acute lung injury caused by paraquat. Intratracheal administration of an adenovirus vector encoding human VASH1 augmented SOD2 and SIRT1 expression in the lungs and prevented acute lung injury caused by paraquat. Thus, VASH1 is a critical factor that improves the stress tolerance of ECs via the induction of SOD2 and SIRT1.
Articulatory-acoustic Feature Recognition: Comparison of Machine Learning and HMM methods

HMMs are the dominating technique used in speech recognition today since they perform well in overall phone recognition. In this paper, we show the comparison of HMM methods and machine learning techniques, such as neural networks, decision trees and ensemble classifiers with boosting and bagging in the task of articulatory-acoustic feature classification. The experimental results show that HMM methods work well for the classification of such features as vocalic. However, decision tree and bagging outperform HMMs for the fricative classification task since the data skewness is much higher than for the feature vocalic classification task. This demonstrates that HMMs do not perform as well as decision trees and bagging in highly skewed data settings.
Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis.

BACKGROUND A combination of prednisone, azathioprine, and N-acetylcysteine (NAC) has been widely used as a treatment for idiopathic pulmonary fibrosis. The safety and efficacy of this three-drug regimen is unknown. METHODS In this randomized, double-blind, placebo-controlled trial, we assigned patients with idiopathic pulmonary fibrosis who had mild-to-moderate lung-function impairment to one of three groups -- receiving a combination of prednisone, azathioprine, and NAC (combination therapy), NAC alone, or placebo -- in a 1:1:1 ratio. The primary outcome was the change in longitudinal measurements of forced vital capacity during a 60-week treatment period. RESULTS When approximately 50% of data had been collected (with 77 patients in the combination-therapy group and 78 in the placebo group), a planned interim analysis revealed that patients in the combination-therapy group, as compared with the placebo group, had an increased rate of death (8 vs. 1, P=0.01) and hospitalization (23 vs. 7, P<0.001). These observations, coupled with no evidence of physiological or clinical benefit for combination therapy, prompted the independent data and safety monitoring board to recommend termination of the combination-therapy group at a mean follow-up of 32 weeks. Data from the ongoing comparison of the NAC-only group and the placebo group are not reported here. CONCLUSIONS Increased risks of death and hospitalization were observed in patients with idiopathic pulmonary fibrosis who were treated with a combination of prednisone, azathioprine, and NAC, as compared with placebo. These findings provide evidence against the use of this combination in such patients. (Funded by the National Heart, Lung, and Blood Institute and the Cowlin Family Fund; ClinicalTrials.gov number, NCT00650091.).