Miracle-dz/UniFAR-FTUs huggingface dataset:
LOWER BOUNDS FOR CHVÁTAL-GOMORY STYLE OPERATORS

Valid inequalities or cutting planes for (mixed-) integer programming problems are an essential theoretical tool for studying combinatorial properties of polyhedra. They are also of utmost importance for solving optimization problems in practice; in fact any modern solver relies on several families of cutting planes. The Chvátal-Gomory procedure, one such approach, has a peculiarity that differentiates it essentially from all other known cutting-plane operators. There exists a family of polytopes in the 0/1 cube for which more than n rounds of Chvátal-Gomory cuts are needed to derive the integral hull where n is the dimension of the polytope. All other known operators achieve this in at most n rounds. We will prove that this behavior is not an inherent weakness of the Chvátal-Gomory operator but rather a consequence of deriving new inequalities solely from a single inequality (not to confuse with single row cuts). We will first introduce a generalization of the Chvátal-Gomory closure which is significantly stronger than the classical Chvátal-Gomory procedure. We will then provide a new bounding technique for rank lower bounds for operators that essentially derive new inequalities from examining a single inequality only. A construction of a family of polytopes whose rank exceeds n follows. Contrasting these results we will show that as soon as the operator can use at least two inequalities for its derivations the rank in 0/1 cube is bounded by n from above and we will construct a new cutting-plane operator, the transient closure that combines a strengthening of lift-and-project cuts and generalized Chvátal-Gomory cuts. We obtain several rank lower bounds for specific families of polytopes in the process.
Conceptual Frameworks for Firm Strategy: An Information Systems Perspective

El concepto de estrategia y formación de estrategia puede ser analizado desde diferentes perspectivas. Mintzberg (1990) ha identificado diez escuelas básicas de pensamiento con relación a este tema. La estrategia es concebida como un proceso de visión, diseño, planeamiento o posicionamiento; como un proceso de conocimiento o aprendizaje, sujeto a influencias políticas, culturales o ambientales, o más propiamente como un proceso centrado en la transformación. A través de los años, los sistemas de información han venido a jugar un papel crecientemente estratégico en los negocios, capaz de apoyar la formulación e implementación de estrategias y, particularmente, la reformulación de estrategias. Este trabajo ofrece una revisión de la literatura sobre el tema y relaciona los sistemas de información con las diez escuelas de estrategia mencionadas, permitiendo la discusión de la utilidad de los diferentes tipos de sistemas de información.
Probability judgments under ambiguity and conflict

Whether conflict and ambiguity are distinct kinds of uncertainty remains an open question, as does their joint impact on judgments of overall uncertainty. This paper reviews recent advances in our understanding of human judgment and decision making when both ambiguity and conflict are present, and presents two types of testable models of judgments under conflict and ambiguity. The first type concerns estimate-pooling to arrive at “best” probability estimates. The second type is models of subjective assessments of conflict and ambiguity. These models are developed for dealing with both described and experienced information. A framework for testing these models in the described-information setting is presented, including a reanalysis of a multi-nation data-set to test best-estimate models, and a study of participants' assessments of conflict, ambiguity, and overall uncertainty reported by Smithson (2013). A framework for research in the experienced-information setting is then developed, that differs substantially from extant paradigms in the literature. This framework yields new models of “best” estimates and perceived conflict. The paper concludes with specific suggestions for future research on judgment and decision making under conflict and ambiguity.
HyPer Family Probes: State of the Art.

SIGNIFICANCE Hydrogen peroxide (H2O2) is not only a key mediator of oxidative stress but also one of the most important cellular second messengers. This small short-lived molecule is involved in the regulation of a wide range of different biological processes, including regulation of cellular signaling pathways. Studying the role of H2O2 in living systems would be challenging without modern approaches. A genetically encoded fluorescent biosensor, HyPer, is one of the most effective tools for this purpose. RECENT ADVANCES HyPer has been used by many investigators of redox signaling in various models of different scales: from cytoplasmic subcompartments and single cells to tissues of whole organisms. In many studies, the results obtained using HyPer have enabled a better understanding of the roles of H2O2 in these biological processes. However, much remains to be learned. CRITICAL ISSUES In this review, we focus on the uses of HyPer. We provide a general description of HyPer and its improved versions. Separate chapters are devoted to the results obtained by various groups who have used this biosensor for their experiments in living cells and organisms. FUTURE DIRECTIONS HyPer is an effective tool for H2O2 imaging in living systems as indicated by the increasing numbers of publications each year since its development. However, this biosensor requires further improvements. In particular, much brighter and more pH-stable versions of HyPer are necessary for imaging in mammalian tissues. Antioxid. Redox Signal. 24, 731-751.
Role of Hormone Therapy After Primary Surgery for Endometrioma

Endometriosis is a major cause of disability in women, and 40% to 50% of patients experience disease recurrence by 5 years after surgery. This multicenter retrospective cohort study (N = 588) determined the rate and risk factors for recurrent endometrioma after primary surgery and examined the role of postoperative hormone therapy. When recurrence was defined by sonographic identification of the endometrioma (≥20 mm in size), 61 (10.4%) patients experienced disease recurrence. The cumulative recurrence rates at 1, 2, 3, and 5 years after surgery were 2.2%, 4.9%, 6.9%, and 9.8%, respectively. To determine the risk factors for recurrence, the clinical factors of patients with and without recurrence were compared. There was a significantly increased risk of recurrence with posterior cul-de-sac (PCDS) obliteration (P = .031) and higher serum cancer antigen 125 (CA125) level (P = .005). A longer postoperative hormonal therapy duration (P < .01), absence of PCDS obliteration (P = .036), and lower serum CA125 level (P = .014) were associated with longer recurrence-free interval on multivariate analysis using the Cox regression model. Postoperative hormone therapy prolonged the interval from the time of surgery to the first recurrence. However, it did not prolong the interval from the end of treatment to the first recurrence. Our results indicate that although long-term postoperative hormone therapy might maintain minimal disease status, it does not control residual disease. Therefore, persistent hormone suppression should be used to prevent disease recurrence.
Digital 3-d headforms representative of chinese workers.

UNLABELLED Headforms are useful for designing and testing various types of personal protective equipment used to protect millions of workers from occupational hazards in China. Although the Chinese national standard of head-and-face dimensions for adults was first published in 1981, headforms based on those dimensions were never developed. In 2006, an anthropometric survey of 3000 Chinese civilian workers was conducted. As part of the survey, 350 subjects were scanned with a Cyberware 3D Rapid Digitizer. The manual measurements and 3-D digital scans from this survey were used to develop 3-D digital headforms that represent Chinese workers. OBJECTIVE The objective of this study was to develop headforms that represent today's Chinese workers. METHODS Ten facial dimensions relevant to respirator fit were chosen for defining a principal component analysis model which divides the user population into five face size categories. Mean facial dimensions from manual measurements were then computed to target the ideal facial dimensions for each size category. Five scans were chosen from each face size category to be used in the construction process. Selected scans were then averaged to construct a representative headform for each face size category. RESULTS Five digital 3-D headforms were developed: small, medium, large, long/narrow, and short/wide. These distinct sizes of digital 3-D headforms take into account the linear distance between landmarks as well as the surface contours captured during the 3-D scan. The dimensions of constructed headforms were within approximately 4 mm between the corresponding computed means and manual measurements of anthropometric landmarks for the sample population in each size category. CONCLUSIONS These new headforms represent the facial size and shape distribution of current Chinese workers and may be useful for respirator research and development. The Chinese medium headform has a wider face width, shorter face length, and smaller nose protrusion when compared with the current U.S. standard headforms. Upon validation, it may be useful to incorporate these dimensions into Chinese and international respiratory protective devices standards.
Juvenile recruitment in loggerhead sea turtles linked to decadal changes in ocean circulation

Given the threats of climate change, understanding the relationship of climate with long‐term population dynamics is critical for wildlife conservation. Previous studies have linked decadal climate oscillations to indices of juvenile recruitment in loggerhead sea turtles (Caretta caretta), but without a clear understanding of mechanisms. Here, we explore the underlying processes that may explain these relationships. Using the eddy‐resolving Ocean General Circulation Model for the Earth Simulator, we generate hatch‐year trajectories for loggerhead turtles emanating from Japan over six decades (1950–2010). We find that the proximity of the high‐velocity Kuroshio Current to the primary nesting areas in southern Japan is remarkably stable and that hatchling dispersal to oceanic habitats itself does not vary on decadal timescales. However, we observe a shift in latitudes of trajectories, consistent with the Pacific Decadal Oscillation (PDO). In a negative PDO phase, the Kuroshio Extension Current (KEC) is strong and acts as a physical barrier to the northward transport of neonates. As a result, hatch‐year trajectories remain mostly below 35°N in the warm, unproductive region south of the Transition Zone Chlorophyll Front (TZCF). During a positive PDO phase, however, the KEC weakens facilitating the neonates to swim north of the TZCF into cooler and more productive waters. As a result, annual cohorts from negative PDO years may face a lack of resources, whereas cohorts from positive PDO years may find sufficient resources during their pivotal first year. These model outputs indicate that the ocean circulation dynamics, combined with navigational swimming behavior, may be a key factor in the observed decadal variability of sea turtle populations.
Hepatocellular carcinoma after kidney transplantation: analysis of Hong Kong Renal Registry

Abstract Kidney transplant recipients have increased risk of cancers when compared with the general population. Hepatocellular carcinoma (HCC) is extremely important in Asia where hepatitis B virus (HBV) infection is endemic. The aim is to study the epidemiological and clinical aspects of all de novo HCC in our kidney transplant recipients. Moreover, various preventive strategies which may help to optimize the outcome will also be discussed. A retrospective review of all patients who developed HCC after kidney transplantation between May 1972 and December 2011 in Hong Kong, based on the data from Hong Kong Renal Registry. After a follow-up period of 40,246 person-years, 20 patients (males 15: females 5) developed HCC. The annual incidence was 49.7/100,000 persons per year. Among them, 16 were HBV carriers, 2 were hepatitis C (HCV) carriers and 2 had HBV and HCV co-infection. Presence of HBV infection was associated with 78-fold higher risk for HCC development. Majority (85%) were asymptomatic when HCC was diagnosed by ultrasound or alpha-fetoprotein surveillance. All patients diagnosed by surveillance received active treatment while 2/3 of symptomatic patients could only receive symptomatic care and died rapidly. In conclusion, HBV infection is the major etiological factor for HCC development in kidney transplant recipients in HBV endemic areas. Regular HCC surveillance appeared to be able to detect early stage cancers which are amenable to treatment and offer the best hope of cure.
The significance of keratinized mucosa on implant health: a systematic review.

BACKGROUND Whether a minimal width of keratinized mucosa (KM) is required to maintain peri-implant tissue health has been a topic of interest. This systematic review and meta-analysis aims to investigate the effect of KM on various peri-implant health-related parameters. METHODS An electronic search of five databases (from 1965 to October 2012) and a hand search of peer-reviewed journals for relevant articles were performed. Human cross-sectional or longitudinal studies with data on the relationship between the amount of KM around dental implants and various peri-implant parameters, with a follow-up period of at least 6 months, were included. RESULTS Eleven studies, seven cross-sectional and four longitudinal, were included. Weighted mean difference (WMD) and confidence interval (CI) were calculated with meta-analyses for each clinical parameter. The results showed statistically significant differences in plaque index (PI) and modified PI (WMD = -0.27, 95% CI = -0.43 to -0.11), modified gingival index (mGI) (WMD = -0.48, 95% CI = -0.70 to -0.27), mucosal recession (MR) (WMD = -0.60 mm, 95% CI = -0.85 to -0.36 mm), and attachment loss (AL) (WMD = -0.35 mm, 95% CI = -0.65 mm to -0.06 mm), all favoring implants with wide KM. However, comparisons of other parameters (bleeding on probing, modified bleeding index, GI, probing depth, and radiographic bone loss) did not reach statistically significant differences. The result of heterogeneity test showed only one parameter (AL, P value for the χ(2) test = 0.30 and I(2) test = 18%) had a low degree of heterogeneity among analyzed studies; meta-analyses of other parameters presented moderate-to-high degree of heterogeneity. Limitations of the present review include limited number of selected studies (n = 11), existence of heterogeneity and publication bias, and only English-written articles searched. CONCLUSION Based on current available evidence, a lack of adequate KM around endosseous dental implants is associated with more plaque accumulation, tissue inflammation, MR, and AL.
Phospholipase D1 and choline kinase-α are interactive targets in breast cancer

A consistent metabolic hallmark observed in multiple cancers is the increase of cellular phosphocholine (PC) and total choline-containing compounds (tCho), which is closely related to malignant transformation, invasion, and metastasis. Enzymes in choline phospholipid metabolism present attractive targets to exploit for treatment, but require a clear understanding of the mechanisms underlying the altered choline phospholipid metabolism observed in cancer. Choline kinase-α (Chk-α) is an enzyme in the Kennedy pathway that phosphorylates free choline (Cho) to PC, and its upregulation in several cancers is a major contributor to increased PC levels. Similarly, increased expression and activity of phospholipase D1 (PLD1), which converts phosphatidylcholine (PtdCho) to phosphatidic acid (PA) and Cho, has been well documented in gastric, ovarian and breast cancer. Here we report a strong correlation between expression of Chk-α and PLD1 with breast cancer malignancy. Data from patient samples established an association between estrogen receptor (ER) status and Chk-α and PLD1 expression. In addition, these two enzymes were found to be interactive. Downregulation of Chk-α with siRNA increased PLD1 expression, and downregulation of PLD1 increased Chk-α expression. Simultaneous silencing of PLD1 and Chk-α in MDA-MB-231 cells increased apoptosis as detected by the TUNEL assay. These data provide new insights into choline phospholipid metabolism of breast cancer, and support multiple targeting of enzymes in choline phospholipid metabolism as a strategy for treatment.
Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker

ABSTRACT Serial activation of the tyrosine kinases Lck and ZAP-70 initiates signaling downstream of the T cell receptor. We previously reported the structure of an autoinhibited ZAP-70 variant in which two regulatory tyrosine residues (315 and 319) in the SH2-kinase linker were replaced by phenylalanine. We now present a crystal structure of ZAP-70 in which Tyr 315 and Tyr 319 are not mutated, leading to the recognition of a five-residue sequence register error in the SH2-kinase linker of the original crystallographic model. The revised model identifies distinct roles for these two tyrosines. As seen in a recently reported structure of the related tyrosine kinase Syk, Tyr 315 of ZAP-70 is part of a hydrophobic interface between the regulatory apparatus and the kinase domain, and the integrity of this interface would be lost upon engagement of doubly phosphorylated peptides by the SH2 domains. Tyr 319 is not necessarily dislodged by SH2 engagement, which activates ZAP-70 only ∼5-fold in vitro. In contrast, phosphorylation by Lck activates ZAP-70 ∼100-fold. This difference is due to the ability of Tyr 319 to suppress ZAP-70 activity even when the SH2 domains are dislodged from the kinase domain, providing stringent control of ZAP-70 activity downstream of Lck.
Worries, confusion after cancer trial deaths.

An experimental cancer therapy is facing its biggest setback yet, after an unexpected complication killed seven people, five of them in a single clinical trial. The company, Seattle, Washington–based Juno Therapeutics, has its most troubled trial on hold and is racing to figure out why patients suffered fatal brain swelling, called cerebral edema. Researchers elsewhere are grappling with possible ramifications for the breakthrough treatment, in which a patient9s T cells are genetically engineered to fight cancer. Called chimeric antigen receptor–T therapy, it goes up for drug approval next year. Doctors speculate that the cerebral edema could be due to the specific product tested and the trial9s patient population, rather than the overall strategy itself. But they9re mostly in the dark, and hope that additional research, including new animal models, could help explain what happened and why.
Optofluidic Approaches for Enhanced Microsensor Performances

Optofluidics is a relatively young research field able to create a tight synergy between optics and micro/nano-fluidics. The high level of integration between fluidic and optical elements achievable by means of optofluidic approaches makes it possible to realize an innovative class of sensors, which have been demonstrated to have an improved sensitivity, adaptability and compactness. Many developments in this field have been made in the last years thanks to the availability of a new class of low cost materials and new technologies. This review describes the Italian state of art on optofluidic devices for sensing applications and offers a perspective for further future advances. We introduce the optofluidic concept and describe the advantages of merging photonic and fluidic elements, focusing on sensor developments for both environmental and biomedical monitoring.
Artefacts: Minecraft meets collaborative interactive evolution

Procedural content generation has shown promise in a variety of different games. In this paper we introduce a new kind of game, called Artefacts, that combines a sandbox-like environment akin to Minecraft with the ability to interactively evolve unique three-dimensional building blocks. Artefacts does not only allow players to collaborate by building larger structures from evolved objects but also to continue evolution of others' artefacts. Results from playtests on three different game iterations indicate that players generally enjoy playing the game and are able to discover a wide variety of different 3D objects. Morever, while there is no explicit goal in Artefacts, the sandbox environment together with the ability to evolve unique shapes does allow for some interesting gameplay to emerge.
Towards Constructivist Teacher Professional Development

Problem statement: In recent years, much has been written about constructivist learning theories and their applications to outcomes-based teaching and learning environments in South Africa. Approach: Little, if any, has been said about the implications of these ideas and practices for teacher professional development and teacher education. The introduction of the National Curriculum Statement (NCS) Policy requires teachers to acquire new skills, knowledge, attitudes and values and to employ a wide variety of teaching strategies, in order to enable students to construct their own knowledge. Results: The purpose of this desktop review is to rethink teacher professional development within a constructivist framework. Conclusion: In this article, we argue that teacher professional development can fit the context and, more specifically, in outcomes-based settings, as well as proposed a move away from a mechanistic world-view (modernist and behaviorist approach) to a holistic world-view (constructivist and situational or contextual approach) of teacher professional development.
Adaptive formative feedback to improve strategic search decisions in task-oriented reading

This study analyses the effectiveness of adaptive formative feedback to boost strategic search decisions and performance when students are asked to answer a set of questions in a task-oriented reading situation. We compared automatic feedback that included information about the right answer with feedback that also included the connection between the students' strategic search decisions and their performance. Ninety-two high school students read two non-continuous texts. They received feedback during a training phase, and then they read and also received feedback with a similar text in a final phase. Text and questions were presented using a new computer-based technology that provided automatic adaptive feedback depending on the experimental condition: right-answer feedback, strategic-search-decisions feedback and placebo feedback. We found that strategic-search-decisions feedback improved strategic decisions over right-answer and placebo feedback in the final text, which in turn improved question-answering performance. Some positive effects were also found during training. These results open new possibilities to adaptive automatic procedures to teach task-oriented reading skills to students.