Miracle-dz/UniFAR-FTUs huggingface dataset:
Bag of Attributes for Video Event Retrieval

In this paper, we present the Bag-of-Attributes (BoA) model for video representation aiming at video event retrieval. The BoA model is based on a semantic feature space for representing videos, resulting in high-level video feature vectors. For creating a semantic space, i.e., the attribute space, we can train a classifier using a labeled image dataset, obtaining a classification model that can be understood as a high-level codebook. This model is used to map low-level frame vectors into high-level vectors (e.g., classifier probability scores). Then, we apply pooling operations to the frame vectors to create the final bag of attributes for the video. In the BoA representation, each dimension corresponds to one category (or attribute) of the semantic space. Other interesting properties are: compactness, flexibility regarding the classifier, and ability to encode multiple semantic concepts in a single video representation. Our experiments considered the semantic space created by state-of-the-art convolutional neural networks pre-trained on 1000 object categories of ImageNet. Such deep neural networks were used to classify each video frame and then different coding strategies were used to encode the probability distribution from the softmax layer into a frame vector. Next, different pooling strategies were used to combine frame vectors in the BoA representation for a video. Results using BoA were comparable or superior to the baselines in the task of video event retrieval using the EVVE dataset, with the advantage of providing a much more compact representation.
Designing Intelligent Robots for Human-Robot Teaming in Urban Search and Rescue

The paper describes ongoing integrated research on designing intelligent robots that can assist humans in making a situation assessment during Urban Search & Rescue (USAR) missions. These robots (rover, microcopter) are deployed during the early phases of an emergency response. The aim is to explore those areas of the disaster hotzone which are too dangerous or too difficult for a human to enter at that point. This requires the robots to be " intelligent " in the sense of being capable of various degrees of autonomy in acting and perceiving in the environment. At the same time, their intelligence needs to go beyond mere task-work. Robots and humans are interdependent. Human operators are dependent on these robots to provide information for a situation assessment. And robots are dependent on humans to help them operate (shared control) and perceive (shared assessment) in what are typically highly dynamic, largely unknown environments. Robots and humans need to form a team. The paper describes how various insights from robotics and Artificial Intelligence are combined , to develop new approaches for modeling human robot teaming. These approaches range from new forms of mod-eling situation awareness (to model distributed acting in dynamic space), human robot interaction (to model communication in teams), flexible planning (to model team coordination and joint action), and cognitive system design (to integrate different forms of functionality in a single system).
Geranylgeraniol and Neurological Impairment: Involvement of Apoptosis and Mitochondrial Morphology

Deregulation of the cholesterol pathway is an anomaly observed in human diseases, many of which have in common neurological involvement and unknown pathogenesis. In this study we have used Mevalonate Kinase Deficiency (MKD) as a disease-model in order to investigate the link between the deregulation of the mevalonate pathway and the consequent neurodegeneration. The blocking of the mevalonate pathway in a neuronal cell line (Daoy), using statins or mevalonate, induced an increase in the expression of the inflammasome gene (NLRP3) and programmed cell death related to mitochondrial dysfunction. The morphology of the mitochondria changed, clearly showing the damage induced by oxidative stress and the decreased membrane potential associated with the alterations of the mitochondrial function. The co-administration of geranylgeraniol (GGOH) reduced the inflammatory marker and the damage of the mitochondria, maintaining its shape and components. Our data allow us to speculate about the mechanism by which isoprenoids are able to rescue the inflammatory marker in neuronal cells, independently from the block of the mevalonate pathway, and about the fact that cell death is mitochondria-related.
A Spatially Consistent Radio Channel Model Enabling Dual Mobility

In a future radio communication network various types of links will co-exist in the same area, and they need to be modelled consistently. We describe a channel modelling framework, which can consistently describe large and small scale phenomena of different types of links. The approach supports generation of spatially consistent radio channel realization also for cases where both link ends are moving like in device-to-device communication. Traditional cellular links and distributed antenna systems can be described with the same model, which allows a fair comparison between different types of transmission schemes. The main principle of the proposed framework is to create the propagation environment independently from the radios like in COST 2100 model. This is like simplified ray tracing without a map, i.e. without need of any detailed geometric or electromagnetic description of the environment as a prerequisite. The modelling principle and some examples of resulting radio channel statistics are simulated and presented.
Underneath It All: Gender Role Identification and Women Chemists' Career Choices.

This paper describes results from a study on the career choices of women earning doctorates in chemistry in the United States. Presented here are findings related to the participants’ identification with traditional female gender roles and expectations for behavior in the male-dominated field of chemistry. Underlying a career decision-making model are the traditional gender roles women participants struggled with as they evaluated different careers in chemistry. Many of the participants envisioned being the primary caretakers for their future families and wanted careers that would accommodate this lifestyle. Findings of note include the freedom from traditional female gender roles exhibited by the lesbian participant, the views towards future familial responsibilities exhibited by both the participants in a relationship and those who were single, and the conflict between feminine personality traits and observed mannerisms of women faculty members. The challenge for research-focused chemistry departments in the United States lies in making departmental culture more supportive of families, more accommodating of the need for work-life balance, and more accepting of traditionally feminine mannerisms and behaviors.
New dataset of emotional and color responses to music

This paper presents a new dataset gathered containing perceived and induced emotions for 200 audio clips. The gathered dataset also provides users’ association of color for each clip, along with users’ demographic and personal data, such as users’ emotion state, preferred genres, music experience and daily inference, and others. With an online survey we collected more than 7000 responses for a dataset of 200 audio excerpts, thus providing about 37 user responses per clip. We introduced a new methodology for gathering user perception of emotions in a form of two new interfaces the MoodGraph and MoodStripe. We present a preliminary evaluation of classifying the present emotions with a regression algorithm on the gathered dataset, and perform a comparison towards other datasets.
Quantitation of pulmonary megakaryocytes and fibrin thrombi in patients dying from burns

Pulmonary megakaryocytes and fibrin microthrombi were counted in lung sections from 22 patients dying from extensive burns. There was a significant correlation between numbers of megakaryocytes and fibrin microthrombi, supporting a relationship between disseminated intravascular coagulation (DIC) and numbers of pulmonary megakaryocytes. No correlation was found between antemortem platelet counts and either fibrin microthrombi or megakaryocytes. Possible explanations for this are forwarded and the nature of pulmonary megakaryocytes discussed.
Intercultural competence in international social work : - A literature review

Intercultural competence is becoming increasingly important in various contexts, including the social work context. This thesis examines intercultural competence and the different imperatives for intercultural competence, connecting them to different approaches to international social work. The hypothesis is that intercultural competence is important in international social work, and the hypothesis will be tested by researching relevant literature. The research questions are: 1. Why is intercultural competence needed? 2. Why is intercultural competence needed specifically among people working in the social field? 3. Why is intercultural competence needed in international social work? The research was conducted as a systematic literature review, with the intention to widen and deepen the already existing knowledge in the field, as well as create a springboard for further studies in the field. The analysis addresses how different approaches to international social work relate to the different imperatives for developing intercultural competence. This was done by categorizing various authors’ reasoning as to why developing intercultural competence is important into different imperatives (both in general and for people working in the social field in specific), and then relating these to different approaches to international social work. Results show that intercultural competence is of great importance in social work in general, as well as in international social work in specific, regardless of which definition of international social work that was examined. This thesis was commissioned by Project Sunshine, a non-profit organization in USA that works with children in hospital and their families. Project Sunshine has a very diverse clientele, and they work both within the USA and internationally, so this thesis can support their work.
Connectionist approaches to natural language processing

Preface, N. Sharkey and R. Reilly connectionist natural language processing semantics, M.D. Dyer, et al distributed symbol discovery through symbol recirculation - toward natural language processing in distributed connectionist networks, R.F. E. Stucliffe representing meaning using microfeatures, S. Wermter and W. Lehnert noun phrase analysis with connectionist networks, M. St John and J. McClelland parallel constraint satisfaction as a comprehension mechanism syntax, J. Rager self-correcting connectionist parsing, H. Schnelle and R. Doust a net-linguistic "Earley" parser representational adequacy, T. Bever the demons and the beast - modular and nodular kinds of knowledge, G. Berg representational adequacy and the case for a hybrid connectionis/market- parsing model, G. Dorffner a step toward sub-symbolic language models without linguistic representation computational psycholinguists, D. Massaro connectionist models of speech perception, D. Norris connectionism - a new breed of bottom up model? , P. O'Seaghdha, et al models of form-related priming in comprehension and production, M. Mozer and M. Behrmann reading with attentional impariments - a brain-damaged model of neglect and attentional dyslexias.
GS-align for glycan structure alignment and similarity measurement

MOTIVATION Glycans play critical roles in many biological processes, and their structural diversity is key for specific protein-glycan recognition. Comparative structural studies of biological molecules provide useful insight into their biological relationships. However, most computational tools are designed for protein structure, and despite their importance, there is no currently available tool for comparing glycan structures in a sequence order- and size-independent manner. RESULTS A novel method, GS-align, is developed for glycan structure alignment and similarity measurement. GS-align generates possible alignments between two glycan structures through iterative maximum clique search and fragment superposition. The optimal alignment is then determined by the maximum structural similarity score, GS-score, which is size-independent. Benchmark tests against the Protein Data Bank (PDB) N-linked glycan library and PDB homologous/non-homologous N-glycoprotein sets indicate that GS-align is a robust computational tool to align glycan structures and quantify their structural similarity. GS-align is also applied to template-based glycan structure prediction and monosaccharide substitution matrix generation to illustrate its utility. AVAILABILITY AND IMPLEMENTATION http://www.glycanstructure. org/gsalign. CONTACT wonpil@ku.edu SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Helicobacter pylori cagA gene and expression of cytokine messenger RNA in gastric mucosa.

BACKGROUND & AIMS Helicobacter pylori strains possessing the cagA gene are thought to be associated with gastroduodenal diseases. Furthermore, some cytokines are considered to play a role in gastric mucosal inflammation. The aim of this study was to investigate the relationship between cagA gene and cytokine messenger RNA (mRNA) expression in gastric mucosa. METHODS In 160 patients, the cagA gene was detected using polymerase chain reaction, and interleukin (IL) 1 beta, IL-6, IL-7, IL-8, IL-10, and tumor necrosis factor (TNF) alpha mRNA were detected using reverse-transcription polymerase chain reaction. RESULTS Specimens infected with cagA gene-positive strains (cagA-positive specimens) had significantly more severe infiltration of polymorphonuclear leukocytes and mononuclear cells than those infected with cagA gene-negative strains (cagA-negative specimens). Levels of expression of IL-6, IL-7, IL-8, IL-10, and TNF-alpha mRNA were significantly higher in H. pylori-positive than H. pylori-negative patients. Furthermore, the level of IL-8 mRNA expression was significantly higher in cagA-positive than cagA-negative specimens. CONCLUSIONS cagA-positive strains induce the expression of IL-8 mRNA, suggesting that IL-8 may play important roles in the pathogenesis of gastroduodenal diseases associated with H. pylori infection.
Accuracy of the Clinical Diagnosis of Alzheimer Disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010

Abstract The neuropathologic examination is considered to provide the gold standard for Alzheimer disease (AD). To determine the accuracy of currently used clinical diagnostic methods, clinical and neuropathologic data from the National Alzheimer’s Coordinating Center, which gathers information from the network of National Institute on Aging (NIA)-sponsored Alzheimer Disease Centers (ADCs), were collected as part of the National Alzheimer’s Coordinating Center Uniform Data Set (UDS) between 2005 and 2010. A database search initially included all 1198 subjects with at least one UDS clinical assessment and who had died and been autopsied; 279 were excluded as being not demented or because critical data fields were missing. The final subject number was 919. Sensitivity and specificity were determined based on “probable” and “possible” AD levels of clinical confidence and 4 levels of neuropathologic confidence based on varying neuritic plaque densities and Braak neurofibrillary stages. Sensitivity ranged from 70.9% to 87.3%; specificity ranged from 44.3% to 70.8%. Sensitivity was generally increased with more permissive clinical criteria and specificity was increased with more restrictive criteria, whereas the opposite was true for neuropathologic criteria. When a clinical diagnosis was not confirmed by minimum levels of AD histopathology, the most frequent primary neuropathologic diagnoses were tangle-only dementia or argyrophilic grain disease, frontotemporal lobar degeneration, cerebrovascular disease, Lewy body disease and hippocampal sclerosis. When dementia was not clinically diagnosed as AD, 39% of these cases met or exceeded minimum threshold levels of AD histopathology. Neurologists of the NIA-ADCs had higher predictive accuracy when they diagnosed AD in subjects with dementia than when they diagnosed dementing diseases other than AD. The misdiagnosis rate should be considered when estimating subject numbers for AD studies, including clinical trials and epidemiologic studies.
Low uptake of eye services in rural India: a challenge for programs of blindness prevention.

OBJECTIVES To investigate service uptake in a rural Indian population served by outreach eye camps and to identify barriers to uptake. PARTICIPANTS AND METHODS A routine eye camp was conducted within 5 km of each of 48 randomly selected villages of typically Hindu, backward-caste communities. Subsequently, participatory rural appraisal-community mapping, focus groups, matrix ranking, and semistructured interviews-was undertaken to explore community views of eye problems. An eye examination was conducted on persons with eye problems who did not attend the eye camp. Predictors of attendance were identified by multilevel regression analysis. RESULTS Of 749 adults with an eye problem, 51 (6.8%) attended the eye camp. Independent predictors of attendance were being male (odds ratio = 2.3; 95% confidence interval, 1.2-4.5) and living within 3 km of the camp (odds ratio = 4.5; 95% confidence interval, 1.7-12.5). Of the 552 persons who did not attend the eye camps and had an eye examination, 242 (43.8%) had low vision (visual acuity <6/18 to > or =3/60 in presenting better eye) and 38 (6.9%) were blind in both eyes. Cataract surgery was recommended for 197 (35.8%) of the persons who did not attend the eye camps. Of 109 persons with a previous cataract operation, 42 (38.5%) had low vision and 11 (10.1%) were blind. Fear (principally of eye damage), cost (direct and indirect), family responsibilities, ageism, fatalism, and an attitude of being able to cope (with low or no vision) were the principal barriers to attending the eye camps. CONCLUSIONS A high proportion of people who could have benefited from eye treatment were not using available services. Poor visual outcomes were observed in surgically treated persons.
Synergistic combination of valproic acid and oncolytic parvovirus H-1PV as a potential therapy against cervical and pancreatic carcinomas

The rat parvovirus H‐1PV has oncolytic and tumour‐suppressive properties potentially exploitable in cancer therapy. This possibility is being explored and results are encouraging, but it is necessary to improve the oncotoxicity of the virus. Here we show that this can be achieved by co‐treating cancer cells with H‐1PV and histone deacetylase inhibitors (HDACIs) such as valproic acid (VPA). We demonstrate that these agents act synergistically to kill a range of human cervical carcinoma and pancreatic carcinoma cell lines by inducing oxidative stress, DNA damage and apoptosis. Strikingly, in rat and mouse xenograft models, H‐1PV/VPA co‐treatment strongly inhibits tumour growth promoting complete tumour remission in all co‐treated animals. At the molecular level, we found acetylation of the parvovirus nonstructural protein NS1 at residues K85 and K257 to modulate NS1‐mediated transcription and cytotoxicity, both of which are enhanced by VPA treatment. These results warrant clinical evaluation of H‐1PV/VPA co‐treatment against cervical and pancreatic ductal carcinomas.
Injury incidence and injury patterns in professional football: the UEFA injury study

Objective To study the injury characteristics in professional football and to follow the variation of injury incidence during a match, during a season and over consecutive seasons. Design Prospective cohort study where teams were followed for seven consecutive seasons. Team medical staff recorded individual player exposure and time-loss injuries from 2001 to 2008. Setting European professional men's football. Participants The first team squads of 23 teams selected by the Union of European Football Associations as belonging to the 50 best European teams. Main outcome measurement Injury incidence. Results 4483 injuries occurred during 566 000 h of exposure, giving an injury incidence of 8.0 injuries/1000 h. The injury incidence during matches was higher than in training (27.5 vs 4.1, p<0.0001). A player sustained on average 2.0 injuries per season, and a team with typically 25 players can thus expect about 50 injuries each season. The single most common injury subtype was thigh strain, representing 17% of all injuries. Re-injuries constituted 12% of all injuries, and they caused longer absences than non re-injuries (24 vs 18 days, p<0.0001). The incidence of match injuries showed an increasing injury tendency over time in both the first and second halves (p<0.0001). Traumatic injuries and hamstring strains were more frequent during the competitive season, while overuse injuries were common during the preseason. Training and match injury incidences were stable over the period with no significant differences between seasons. Conclusions The training and match injury incidences were stable over seven seasons. The risk of injury increased with time in each half of matches.
Interactions between adenylate cyclase and the yeast GTPase-activating protein IRA1

The adenylate cyclase system of the yeast Saccharomyces cerevisiae contains many proteins, including the CYR1 polypeptide, which is responsible for catalyzing the formation of cyclic AMP from ATP, RAS1 and RAS2 polypeptides, which mediate stimulation of cyclic AMP synthesis by guanine nucleotides, and the yeast GTPase-activating protein analog IRA1. We have previously reported that adenylate cyclase is only peripherally bound to the yeast membrane. We have concluded that IRA1 is a strong candidate for a protein involved in anchoring adenylate cyclase to the membrane. We base this conclusion on the following criteria: (i) a disruption of the IRA1 gene produced a mutant with very low membrane-associated levels of adenylate cyclase activity, (ii) membranes made from these mutants were incapable of binding adenylate cyclase in vitro, (iii) IRA1 antibodies inhibit binding of adenylate cyclase to the membrane, and (iv) IRA1 and adenylate cyclase comigrate on Sepharose 4B.
A Mitochondrial Membrane Exopolyphosphatase Is Modulated by, and Plays a Role in, the Energy Metabolism of Hard Tick Rhipicephalus (Boophilus) microplus Embryos

The physiological roles of polyphosphates (polyP) recently found in arthropod mitochondria remain obscure. Here, the relationship between the mitochondrial membrane exopolyphosphatase (PPX) and the energy metabolism of hard tick Rhipicephalus microplus embryos are investigated. Mitochondrial respiration was activated by adenosine diphosphate using polyP as the only source of inorganic phosphate (Pi) and this activation was much greater using polyP3 than polyP15. After mitochondrial subfractionation, most of the PPX activity was recovered in the membrane fraction and its kinetic analysis revealed that the affinity for polyP3 was 10 times stronger than that for polyP15. Membrane PPX activity was also increased in the presence of the respiratory substrate pyruvic acid and after addition of the protonophore carbonyl cyanide-p-trifluoromethoxyphenylhydrazone. Furthermore, these stimulatory effects disappeared upon addition of the cytochrome oxidase inhibitor potassium cyanide and the activity was completely inhibited by 20 μg/mL heparin. The activity was either increased or decreased by 50% upon addition of dithiothreitol or hydrogen peroxide, respectively, suggesting redox regulation. These results indicate a PPX activity that is regulated during mitochondrial respiration and that plays a role in adenosine-5′-triphosphate synthesis in hard tick embryos.