Miracle-dz/UniFAR-FTUs huggingface dataset:
ℋ︁∞ and l2–l∞ filtering for two‐dimensional linear parameter‐varying systems

In this paper, the ℋ︁∞ and l2–l∞ filtering problem is investigated for two‐dimensional (2‐D) discrete‐time linear parameter‐varying (LPV) systems. Based on the well‐known Fornasini–Marchesini local state‐space (FMLSS) model, the mathematical model of 2‐D systems under consideration is established by incorporating the parameter‐varying phenomenon. The purpose of the problem addressed is to design full‐order ℋ︁∞ and l2–l∞ filters such that the filtering error dynamics is asymptotic stable and the prescribed noise attenuation levels in ℋ︁∞ and l2–l∞ senses can be achieved, respectively. Sufficient conditions are derived for existence of such filters in terms of parameterized linear matrix inequalities (PLMIs), and the corresponding filter synthesis problem is then transformed into a convex optimization problem that can be efficiently solved by using standard software packages. A simulation example is exploited to demonstrate the usefulness and effectiveness of the proposed design method. Copyright © 2007 John Wiley & Sons, Ltd.
Behaviour of Low Energy Electrons Precipitating in the Upper Atmosphere-An Approach with the Discrete Ordinate Method

The energy degradation of precipitating electrons with an energy range from 50eV to 600eV is investigated with special attention to the effect of anisotropic elastic collision. The discrete ordinate method is used for solving pitch angle distribution. It is found that pitch angle distribution of the penetrating fluxes are affected strongly by the phase function of scattering. The backscattered flux of several tenths of magnitude of the incident flux is obtained throughout energy range concerned. Pitch angle scattering due to elastic collision reduces the penetrating depth of electrons obtained in the case where only inelastic collisions are considered. Discussions on the validity of the discrete ordinate method are carried out.
Fundamentals Of Topographic Substrate Leveling

The leveling of 100 - 500 μm wide, 1 pm deep isolated holes and trenches by 1 - 3 μm thick silicone oil films was observed by measuring film thickness changes at the centers of the features using a non-contact, interferometric technique. The dependence of the leveling time t on feature width w, film viscosity n and the initial film thickness h0 was investigated and compared to theoretical predictions. Experimental data were obtained for various values of w, n and ho. Except when the film thickness was about 1 μm the data for each different type of geometry fell on a single curve when the degree of leveling or planarization was plotted against T E tyh03/nw4 where y is the surface tension of the film. At the same value of T, the degree of planarization of isolated holes was about twice that of isolated trenches. The planarization vs. T curves should apply to all Newtonian liquids and may be used to predict the degree of planarization that will be achieved at specified leveling times by materials having specified values of n, h0 and Y. Thus, the curves may be useful in selecting planarizing materials for semiconductor fabrication steps that require substrate topography leveling. Simulations of the leveling process based on capillarity-driven flow were performed and agreed well with the experimental data. The simulations predicted some interesting and unexpected behavior that was observed experimentally. At short times the planarization worsened before improving at longer times, and "humps" appeared in the film profiles that apparently are a first step in minimizing surface energy. Such simulations may prove to be useful in predicting the difficulty of planarizing various types of topographic geometries.
Studying the Association between Antibiotic Resistance Genes and Insertion Sequences in Metagenomes: Challenges and Pitfalls

Antibiotic resistance is an issue in many areas of human activity. The mobilization of antibiotic resistance genes within the bacterial community makes it difficult to study and control the phenomenon. It is known that certain insertion sequences, which are mobile genetic elements, can participate in the mobilization of antibiotic resistance genes and in the expression of these genes. However, the magnitude of the contribution of insertion sequences to the mobility of antibiotic resistance genes remains understudied. In this study, the relationships between insertion sequences and antibiotic resistance genes present in the microbiome were investigated using two public datasets. The first made it possible to analyze the effects of different antibiotics in a controlled mouse model. The second dataset came from a study of the differences between conventional and organic-raised cattle. Although it was possible to find statistically significant correlations between the insertion sequences and antibiotic resistance genes in both datasets, several challenges remain to better understand the contribution of insertion sequences to the motility of antibiotic resistance genes. Obtaining more complete and less fragmented metagenomes with long-read sequencing technologies could make it possible to understand the mechanisms favoring horizontal transfers within the microbiome with greater precision.
“It’s All about Calculations—But There Are No Definite Results”—Parental Adaptation and Coping during the First Month following Their Child’s Diabetes Diagnosis

Diabetes-related habits established during the first few years after diagnosis are difficult to change. Therefore, the initial period after a child has been diagnosed with diabetes holds a unique potential for early interventions to adjust adverse patterns of diabetes self-management before they become firmly established. Family functioning is strongly related to glycemic levels, and attending to parents’ needs at the time of diagnosis could therefore reduce psychological distress and improve glycemic levels in their children. This study aims to investigate parental adaptation to and coping with their child’s diabetes diagnosis during the first month post-diagnosis. Twenty interviews with parents of children (0–18 years) with newly diagnosed type 1 diabetes were conducted and analyzed using systematic text condensation. Four themes were identified: (1) Removal of the safety net, when families experience that they are now on their own; (2) Hit by the realities, when parents realize the impact of living with diabetes; (3) Hang in there, when families mobilize resources to get them through a tough period; and (4) Toward a new normal, when parents begin to reestablish their life with diabetes in mind. This study generated unique insights into early parental adaptation and coping after their child was diagnosed with diabetes.
Artificial intelligence empowers the second-observer strategy for colonoscopy: a randomized clinical trial

Abstract Background In colonoscopy screening for colorectal cancer, human vision limitations may lead to higher miss rate of lesions; artificial intelligence (AI) assistance has been demonstrated to improve polyp detection. However, there still lacks direct evidence to demonstrate whether AI is superior to trainees or experienced nurses as a second observer to increase adenoma detection during colonoscopy. In this study, we aimed to compare the effectiveness of assistance from AI and human observer during colonoscopy. Methods A prospective multicenter randomized study was conducted from 2 September 2019 to 29 May 2020 at four endoscopy centers in China. Eligible patients were randomized to either computer-aided detection (CADe)-assisted group or observer-assisted group. The primary outcome was adenoma per colonoscopy (APC). Secondary outcomes included polyp per colonoscopy (PPC), adenoma detection rate (ADR), and polyp detection rate (PDR). We compared continuous variables and categorical variables by using R studio (version 3.4.4). Results A total of 1,261 (636 in the CADe-assisted group and 625 in the observer-assisted group) eligible patients were analysed. APC (0.42 vs 0.35, P = 0.034), PPC (1.13 vs 0.81, P < 0.001), PDR (47.5% vs 37.4%, P < 0.001), ADR (25.8% vs 24.0%, P = 0.464), the number of detected sessile polyps (683 vs 464, P < 0.001), and sessile adenomas (244 vs 182, P = 0.005) were significantly higher in the CADe-assisted group than in the observer-assisted group. False detections of the CADe system were lower than those of the human observer (122 vs 191, P < 0.001). Conclusions Compared with the human observer, the CADe system may improve the clinical outcome of colonoscopy and reduce disturbance to routine practice (Chictr.org.cn No.: ChiCTR1900025235).
Metatranscriptomic Analyses Reveal Important Roles of the Gut Microbiome in Primate Dietary Adaptation

The gut microbiome plays a vital role in host ecological adaptation, especially dietary adaptations. Primates have evolved a variety of dietary and gut physiological structures that are useful to explore the role of the gut microbiome in host dietary adaptations. Here, we characterize gut microbiome transcriptional activity in ten fecal samples from primates with three different diets and compare the results to their previously reported metagenomic profile. Bacteria related to cellulose degradation, like Bacteroidaceae and Alcaligenaceae, were enriched and actively expressed in the gut microbiome of folivorous primates, and functional analysis revealed that the glycan biosynthesis and metabolic pathways were significantly active. In omnivorous primates, Helicobacteraceae, which promote lipid metabolism, were significantly enriched in expression, and activity and xenobiotic biodegradation and metabolism as well as lipid metabolism pathways were significantly active. In frugivorous primates, the abundance and activity of Elusimicrobiaceae, Neisseriaceae, and Succinivibrionaceae, which are associated with digestion of pectin and fructose, were significantly elevated, and the functional pathways involved in the endocrine system were significantly enriched. In conclusion, the gut microbiome contributes to host dietary adaptation by helping hosts digest the inaccessible nutrients in their specific diets.
Factors That Influence, Exacerbate, Contribute or Promote Violence in Couples

Life as a couple, and their ability to solve problems or not, can result in the relationship being satisfactory and functional or unsatisfactory and dysfunctional, which increases the risk of violence with serious implications. For that reason, it is important to isolate the risk factors to prevent and treat unsatisfactory and dysfunctional relationships. The qualitative interpretive exploratory method was used, analysing 50 sessions of group psychotherapy with patients from a reproductive health institution whose relationships faced violent problems. The identified factors were the lack of autonomy in one of the partners, unresolved internal factors, a combination of external factors and factors caused by their interaction; symmetrical and asymmetrical violence, subjugation of one before the other, intergenerational violence, family violence during childhood and normalisation of violence. Isolating factors to understand relationship problems at risk of manifesting violence opens the possibility of effective, specific and preventive treatments of family and intimate partner violence.
Cerebral Hemodynamic Changes during Unaffected Handgrip Exercises in Stroke Patients: An fNIRS Study

This study aimed to assess the effect of the altered strength of the sound limb on the hemodynamics in the affected brain of stroke patients. We recruited 20 stroke patients to detect changes in the HbO concentrations in the bilateral prefrontal cortex (PFC), sensorimotor cortex (SMC), and occipital lobe (OL). We performed functional near-infrared spectroscopy (fNIRS) to detect changes in oxyhemoglobin (HbO) concentrations in regions of interest (ROIs) in the bilateral cerebral hemispheres of stroke patients while they performed 20%, 50%, and 80% maximal voluntary contraction (MVC) levels of handgrip tasks with the unaffected hands. The results suggest that when patients performed handgrip tasks with 50% of the MVC force, SMC in the affected cerebral hemisphere was strongly activated and the change in the HbO concentration was similar to that of the handgrip with 80% of MVC. When the force was 50% of MVC, the SMC in the affected hemisphere showed a more proportional activation than that at 80% MVC. Overall, this research suggests that stroke patients with a poor upper limb function should perform motor training with their sound hands at 50% of the MVC grip task to activate the ipsilesional hemisphere.
Effectiveness of clinical integrated short course training of evidence based medicine for postgraduate medical specialty students in Ethiopia in 2022: A randomized control trial

Background Evidence based medicine (EBM) is a newly emerged philosophy of medical education and health care service which brings quality of health service, efficient use of materials, and patient satisfaction. Objective To investigate the effectiveness of clinical integrated short course training of EBM for post-graduation medical specialty students in Ethiopia, 2022. Method Randomized, single blind, superiority trial, and multi-centric experimental study design employed. The eligible candidates randomly assigned to the interventional group and the control group (waitlisted). The allocation of the participant concealed from the principal investigator and participant. Sample size was determined with a two-sided test and α level of 5% and 80% power with the total of 52 calculated sample size and 44 (21 for intervention and 23 for control group) students were used for final analysis. Mann Whitney U test and Independent Sample T test used to test mean difference between intervention and control group after checking normality distributions to estimates the amount by which the training changes the outcome on average compared with the control. The result of the final model expressed in terms of adjusted mean difference and 95% CI; statistical significance declared if the P-value is less than 0.05. Results Among 44 postgraduate students, only 29.5% practices EBM during delivering of clinical services. Overall EBM knowledge was changed with adjusted mean difference (Mean±SD 17.55 (13.9, 21.3), p<000). This training provided significant change in all main domain of EBM, more in validity evaluation of the study (Mean±SD, 3.8(1.3, 6.2), p<0.0018) and impact of study design (Mean±SD, 3.8(2.6, 5.1), p<0.000). There was also significant change of overall attitude with adjusted mean difference (Mean±SD, -8.2(-9.6,-6.7), p = 000). Conclusion Clinical integrated EBM training brought significant change of knowledge and skills of principles and foundations of EBM. Adopting principles of EBM into curricula of postgraduate specialty students would assure the quality of medical care and educations.
Effects of Amylopectins from Five Different Sources on Disulfide Bond Formation in Alkali-Soluble Glutenin

Wheat, maize, cassava, mung bean and sweet potato starches have often been added to dough systems to improve their hardness. However, inconsistent effects of these starches on the dough quality have been reported, especially in refrigerated dough. The disulfide bond contents of alkali-soluble glutenin (ASG) have direct effects on the hardness of dough. In this paper, the disulfide bond contents of ASG were determined. ASG was mixed and retrograded with five kinds of amylopectins from the above-mentioned botanical sources, and a possible pathway of disulfide bond formation in ASGs by amylopectin addition was proposed through molecular weight, chain length distribution, FT-IR, 13C solid-state NMR and XRD analyses. The results showed that when wheat, maize, cassava, mung bean and sweet potato amylopectins were mixed with ASG, the disulfide bond contents of alkali-soluble glutenin increased from 0.04 to 0.31, 0.24, 0.08, 0.18 and 0.29 μmol/g, respectively. However, after cold storage, they changed to 0.55, 0.16, 0.26, 0.07 and 0.19 μmol/g, respectively. The addition of wheat amylopectin promoted the most significant disulfide bond formation of ASG. Hydroxyproline only existed in the wheat amylopectin, indicating that it had an important effect on the disulfide bond formation of ASG. Glutathione disulfides were present, as mung bean and sweet potato amylopectin were mixed with ASG, and they were reduced during cold storage. Positive/negative correlations between the peak intensity of the angles at 2θ = 20°/23° and the disulfide bond contents of ASG existed. The high content of hydroxyproline could be used as a marker for breeding high-quality wheat.
Theoretical model of the solar corona during sunspot minimum. II - Dynamic approximation

The theoretical quasi-static model of the solar corona during sunspot minimum developed in an earlier paper (Osherovich et al., 1984) is extended to include a quasi-radial outflow. The requirement imposed in the above paper on a plasma flow is relaxed. The dynamic equation derived for the combination of a dipole-like and a radial field is used to calculate the electric current density around the sun in the region 1.5-5 solar radii. Comparison with the current density given by the quasi-static model shows that the outflow decreases the current density only slightly in the dynamic case. The dynamic coronal model with a magnetic quadrupole field is also considered, in relation to the north-south asymmetry in the solar corona.
Do powerful CEOs matter for earnings quality? Evidence from Bangladesh

This study investigates the effects of powerful Chief Executive Officers (CEOs) on earnings quality in a setting where CEOs have strong dominance over other top executives and occasionally attempt to exert their influence over corporate regulatory bodies. Using 10-year longitudinal data for the period from 2010 to 2019 and 1,395 firm-year observations from listed non-financial firms in Bangladesh, we found that CEOs’ political power and CEOs with high structural and expert power have a significant detrimental effect on earnings quality. Ownership and prestige power have an insignificant impact on earnings quality. These powerful CEOs use accrual and real activity manipulation techniques together to manage the earnings. This study uses the system-generalized method of moment estimates for estimation purposes, and the results remain robust when alternative earnings quality proxies are used. Taken together, our results suggest that CEOs’ political duality (i.e., serving simultaneously as a member of parliament and a CEO) should be restricted and that a CEO’s tenure should be limited to a reasonable period. This research adds to the existing body of knowledge by offering empirical support for CEO power dynamics on earnings quality, specifically political and prestige power.
Prevention of high-luminosity carbon stars by hot bottom burning

CNO abundances are presented for theoretical models of asymptotic giant branch stars of 4, 5, and 6 M ○. with Z=0.02 and Z=0.001. Self-consistent stellar evolutionary models were computed, starting on the pre-main sequence and terminating after a series of helium shell flashes on the asymptotic giant branch (AGB). The 5 and 6 M ○. cases encountered hot bottom burning, with temperatures at the base of the convective envelope reaching (60-80)×10 6 K for Z=0.02 and (80-100)×10 6 K for Z=0.001. A luminosity boundary near M C bol ∼−6.4 is predicted; for brighter luminosities, hot bottom burning will prevent carbon star formation (these will be S stars, with 3≤ 12 C/ 13 C≤18, and for a period they will be super lithium-rich)
Informational Needs for Dental-Oriented Electronic Health Records from Dentists’ Perspectives

Introduction: Information technology is vital to support dental care services and is yet to be thoroughly investigated. This study aims to assess the dentists’ needs and requirements for health records from dental care providers’ perspectives. Methods: In-depth interviews were conducted with dentists during clinic practices. This qualitative research method involves exploring the information and functions dentists use to obtain information from EHR. The target population is the dental staff interacting with the patients and accessing the electronic health records in the government and private sectors. Results: Thirty-five dentists were interviewed directly after the treatment session and asked four pre-defined questions, the dentists’ needs were collected, and the met and unmet needs were presented. The interview results revealed 42 needs (15 were met and 27 were unmet), with an average of 1.17 needs per session. The information needs were categorized into foreground and background information needs and reported in nine main themes. Discussion: The interviews were analyzed, and as a result, nine themes were generated: chief complaints and symptoms, medical and health history, medications, visual representations of the problem, treatment procedures, X-ray services, needs related to advanced features, needs related to insurance coverage, and finally, information needs related to the treatment environment. The required information and functions mentioned by dentists in the study emphasize the need for integrated modules for oral and medical care services. Generally, it is evident that dentists have substantial unmet needs, and the desired EHR should have functions that cover all dentists’ needs. Conclusion: The study’s findings demonstrate gaps between current and desired EHR to serve dentists’ needs. Dentists need better access to patient history and medical information, progress notes, and X-rays to provide visualization tools for problems and patient charts. Moreover, essential needs were related to messaging capability, educational tools, availability of tutorial videos, and accessing external resources. Information needs were described and should be considered when designing EHR to meet all dentists’ needs.
Impact of Nitrite Supplementation on Bioactive Peptides during Sausage Processing

The goal of this investigation was to examine the impact of nitrite supplementation on the concentration, antioxidant properties, and species of antioxidant peptides in fermented sausages. The polypeptide concentration in nitrite-supplemented sausages was markedly elevated during sausage processing compared to the blank control (p < 0.05). Moreover, nitrite supplementation in fermented sausages markedly enhanced the DPPH, as well as the ABTS, hydroxyl radical, and superoxide anion free radical scavenging abilities (FRSA) of polypeptides (p < 0.05). The ferrous ion chelating ability was also significantly enhanced (p < 0.05). Based on the liquid chromatograph-mass spectrometer (LC-MS) analysis of the sausage, LPGGGHGDL, TKYRVP, FLKMN, SAGNPN, GLAGA, LPGGGT, DLEE, GKFNV, GLAGA, AEEEYPDL, HCNKKYRSEM, TSNRYHSYPWG, and other polypeptides exhibited antioxidant properties. Moreover, the number of species of antioxidant polypeptides in the nitrite-supplemented sausage was greater in comparison to the controls. Based on this evidence, it may be concluded that nitrite supplementation positively modulated antioxidant polypeptide formation in fermented sausages, thereby providing strong evidence that nitrite supplementation significantly enhances sausage quality.