Miracle-dz/UniFAR-FTUs huggingface dataset:
Perioperative utility of goal-directed therapy in high-risk cardiac patients undergoing coronary artery bypass grafting: “A clinical outcome and biomarker-based study”

Goal-directed therapy (GDT) encompasses guidance of intravenous (IV) fluid and vasopressor/inotropic therapy by cardiac output or similar parameters to help in early recognition and management of high-risk cardiac surgical patients. With the aim of establishing the utility of perioperative GDT using robust clinical and biochemical outcomes, we conducted the present study. This multicenter randomized controlled study included 130 patients of either sex, with European system for cardiac operative risk evaluation ≥3 undergoing coronary artery bypass grafting on cardiopulmonary bypass. The patients were randomly divided into the control and GDT group. All the participants received standardized care; arterial pressure monitored through radial artery, central venous pressure (CVP) through a triple lumen in the right internal jugular vein, electrocardiogram, oxygen saturation, temperature, urine output per hour, and frequent arterial blood gas (ABG) analysis. In addition, cardiac index (CI) monitoring using FloTrac™ and continuous central venous oxygen saturation (ScVO2) using PreSep™ were used in patients in the GDT group. Our aim was to maintain the CI at 2.5–4.2 L/min/m2, stroke volume index 30–65 ml/beat/m2, systemic vascular resistance index 1500–2500 dynes/s/cm5/m2, oxygen delivery index 450–600 ml/min/m2, continuous ScVO2 >70%, and stroke volume variation <10%; in addition to the control group parameters such as CVP 6–8 mmHg, mean arterial pressure 90–105 mmHg, normal ABG values, oxygen saturation, hematocrit value >30%, and urine output >1 ml/kg/h. The aims were achieved by altering the administration of IV fluids and doses of inotropes or vasodilators. The data of sixty patients in each group were analyzed in view of ten exclusions. The average duration of ventilation (19.89 ± 3.96 vs. 18.05 ± 4.53 h, P = 0.025), hospital stay (7.94 ± 1.64 vs. 7.17 ± 1.93 days, P = 0.025), and Intensive Care Unit (ICU) stay (3.74 ± 0.59 vs. 3.41 ± 0.75 days, P = 0.012) was significantly less in the GDT group, compared to the control group. The extra volume added and the number of inotropic dose adjustments were significantly more in the GDT group. The two groups did not differ in duration of inotropic use, mortality, and other complications. The perioperative continuation of GDT affected the early decline in the lactate levels after 6 h in ICU, whereas the control group demonstrated a settling lactate only after 12 h. Similarly, the GDT group had significantly lower levels of brain natriuretic peptide, neutrophil gelatinase-associated lipocalin levels as compared to the control. The study clearly depicts the advantage of GDT for a favorable postoperative outcome in high-risk cardiac surgical patients.
Perceived School Climate and Students' Mental Health

1Kharazmi University, Tehran, IR Iran 2Quality Improvement in Clinical Education Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran 3Islamic Azad University, Science and Research Branch, Fars, IR Iran *Corresponding author: Mohammad Reza Dehghani, Quality Improvement in Clinical Education Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran. Fax: +98-713233064, E-mail: Dehghani_m@sums.ac. ir
Medial Features for Superpixel Segmentation

Image segmentation plays an important role in computer vision and human scene perception. Image oversegmentation is a common technique to overcome the problem of managing the high number of pixels and the reasoning among them. Specifically, a local and coherent cluster that contains a statistically homogeneous region is denoted as a superpixel. In this paper we propose a novel algorithm that segments an image into superpixels employing a new kind of shape centered feature which serve as a seed points for image segmentation, based on Gradient Vector Flow fields (GVF) [14]. The features are located at image locations with salient symmetry. We compare our algorithm to state-of-the-art superpixel algorithms and demonstrate a performance increase on the standard Berkeley Segmentation Dataset.
Population genomic and genome-wide association studies of agroclimatic traits in sorghum

Accelerating crop improvement in sorghum, a staple food for people in semiarid regions across the developing world, is key to ensuring global food security in the context of climate change. To facilitate gene discovery and molecular breeding in sorghum, we have characterized ∼265,000 single nucleotide polymorphisms (SNPs) in 971 worldwide accessions that have adapted to diverse agroclimatic conditions. Using this genome-wide SNP map, we have characterized population structure with respect to geographic origin and morphological type and identified patterns of ancient crop diffusion to diverse agroclimatic regions across Africa and Asia. To better understand the genomic patterns of diversification in sorghum, we quantified variation in nucleotide diversity, linkage disequilibrium, and recombination rates across the genome. Analyzing nucleotide diversity in landraces, we find evidence of selective sweeps around starch metabolism genes, whereas in landrace-derived introgression lines, we find introgressions around known height and maturity loci. To identify additional loci underlying variation in major agroclimatic traits, we performed genome-wide association studies (GWAS) on plant height components and inflorescence architecture. GWAS maps several classical loci for plant height, candidate genes for inflorescence architecture. Finally, we trace the independent spread of multiple haplotypes carrying alleles for short stature or long inflorescence branches. This genome-wide map of SNP variation in sorghum provides a basis for crop improvement through marker-assisted breeding and genomic selection.
Modulation of V1 Spike Response by Temporal Interval of Spatiotemporal Stimulus Sequence

The spike activity of single neurons of the primary visual cortex (V1) becomes more selective and reliable in response to wide-field natural scenes compared to smaller stimuli confined to the classical receptive field (RF). However, it is largely unknown what aspects of natural scenes increase the selectivity of V1 neurons. One hypothesis is that modulation by surround interaction is highly sensitive to small changes in spatiotemporal aspects of RF surround. Such a fine-tuned modulation would enable single neurons to hold information about spatiotemporal sequences of oriented stimuli, which extends the role of V1 neurons as a simple spatiotemporal filter confined to the RF. In the current study, we examined the hypothesis in the V1 of awake behaving monkeys, by testing whether the spike response of single V1 neurons is modulated by temporal interval of spatiotemporal stimulus sequence encompassing inside and outside the RF. We used two identical Gabor stimuli that were sequentially presented with a variable stimulus onset asynchrony (SOA): the preceding one (S1) outside the RF and the following one (S2) in the RF. This stimulus configuration enabled us to examine the spatiotemporal selectivity of response modulation from a focal surround region. Although S1 alone did not evoke spike responses, visual response to S2 was modulated for SOA in the range of tens of milliseconds. These results suggest that V1 neurons participate in processing spatiotemporal sequences of oriented stimuli extending outside the RF.
64Cu-ATSM internal radiotherapy to treat tumors with bevacizumab-induced vascular decrease and hypoxia in human colon carcinoma xenografts

Bevacizumab, an anti-vascular endothelial growth factor (VEGF) antibody, is an antiangiogenic agent clinically used for various cancers. However, repeated use of this agent leads to tumor-decreased vascularity and hypoxia with activation of an HIF-1 signaling pathway, which results in drug delivery deficiency and induction of malignant behaviors in tumors. Here, we developed a novel strategy to treat tumors with bevacizumab-induced vascular decrease and hypoxia using 64Cu-diacetyl-bis (N4-methylthiosemicarbazone) (64Cu-ATSM), a potential theranostic agent, which possesses high tissue permeability and can target over-reduced conditions under hypoxia in tumors, with a human colon carcinoma HT-29 tumor-bearing mouse model. The long-term treatment with bevacizumab caused decreased blood vessel density and activation of an HIF-1 signaling pathway; increased uptake of 64Cu-ATSM was also observed despite limited blood vessel density in HT-29 tumors. In vivo high-resolution SPECT/PET/CT imaging confirmed reduced vascularity and increased proportion of 64Cu-ATSM uptake areas within the bevacizumab-treated tumors. 64Cu-ATSM therapy was effective to inhibit tumor growth and prolong survival of the bevacizumab-treated tumor-bearing mice without major adverse effects. In conclusion, 64Cu-ATSM therapy effectively enhanced anti-tumor effects in tumors with bevacizumab-induced vascular decrease and hypoxia. 64Cu-ATSM therapy could represent a novel approach as an add-on to antiangiogenic therapy.
On the optimal risk allocation problem

The optimal risk allocation problem or equivalently the problem of risk sharing is the problem to allocate a risk in an optimal way to n traders endowed with risk measures ϱ1, …, ϱn. This problem has a long history in mathematical economics and insurance. In the first part of the paper we review some mathematical tools and discuss their applications to various problems on risk measures related to the allocation problem like to monotonicity properties of optimal allocations, to optimal investment problems or to an appropriate definition of the conditional value at risk. We then consider the risk allocation problem for convex risk measures ϱi. In general the optimal risk allocation problem is well defined only under an equilibrium condition. This condition can be characterized by the existence of a common scenario measure. We formulate ameaningful modification of the optimal risk allocation problem also formarkets without assuming the equilibrium condition and characterize optimal solutions. The basic idea is to restrict the class of admissible allocations in a proper way.
Predictors of orthostatic hypotension in patients attending a transient ischaemic attack clinic: Database study

Abstract Background. Orthostatic hypotension (OH) is common amongst the older population and is associated with morbidity and mortality. We sought to investigate predictors of OH to assist the clinician in identifying patients at risk. Methods and results. Database of 2696 patients attending a transient ischaemic attack (TIA) clinic between January 2006 and May 2009 was examined. Logistic regression models were constructed to determine clinical associates of OH. Demographics, co-morbidities, cardiovascular risk factors and medications were included in the multivariate models. Simple data mining models in the form of rule sets were developed for each component and they were assessed for predictive accuracy. The best models were validated on a smaller sample. Prevalence of OH was 22.3% in the TIA clinic population (50.6% men, mean 72 years; 49.4% women, mean 75 years). A significant postural drop in systolic blood pressure (BP) (≥ 20 mmHg) was more prevalent than a significant diastolic BP drop (≥ 10 mmHg). Isolated systolic hypertension was common (52.4%). Common factors predicting a significant systolic and diastolic BP fall were older age, previous TIA, being a current smoker, having diabetes and the use of beta-blockers. Both mean arterial and pulse pressure (MAP and PP) derived from supine BP were significantly associated with OH. Conclusions. OH should be assessed routinely in TIA clinics. MAP and PP may provide information on the predictability of OH.
Hes6 acts in a positive feedback loop with the neurogenins to promote neuronal differentiation

proneural bHLH proteins but not by the Notch pathway. When ectopically expressed in Xenopus embryos, Hes6 promotes neurogenesis. The properties of Hes6 distinguish it from other members of the WRPW-bHLH family in vertebrates, and suggest that it acts in a positive-feedback loop with the proneural bHLH proteins to promote neuronal differentiation.
We need to talk: HCI and the delicate topic of spoken language interaction

Speech and natural language remain our most natural form of interaction; yet the HCI community have been very timid about focusing their attention on designing and developing spoken language interaction techniques. This may be due to a widespread perception that perfect domain-independent speech recognition is an unattainable goal. Progress is continuously being made in the engineering and science of speech and natural language processing, however, and there is also recent research that suggests that many applications of speech require far less than 100% accuracy to be useful in many contexts. Engaging the CHI community now is timely -- many recent commercial applications, especially in the mobile space, are already tapping the increased interest in and need for natural user interfaces (NUIs) by enabling speech interaction in their products. As such, the goal of this panel is to bring together interaction designers, usability researchers, and general HCI practitioners to discuss the opportunities and directions to take in designing more natural interactions based on spoken language, and to look at how we can leverage recent advances in speech processing in order to gain widespread acceptance of speech and natural language interaction.
Nitrous Oxide Impairs the Neutrophil Oxidative Response

Background Nitrous oxide has been shown inconsistently to impair the oxidative function of neutrophils. The choice of the stimulus, receptor agonists, or stimuli acting independent of receptors seems to determine whether nitrous oxide impairs the oxidative functions, suggesting an interference with the cytosolic signaling of neutrophils. Methods Production of hydrogen peroxide by neutrophils was assessed using flow cytometric analysis. N‐formyl‐methionyl‐leucyl‐phenylalanine (FMLP), C5a, dioctanylglycerol, and phorbol‐12‐myristate‐13‐acetate were used as stimuli. In addition, the expression of receptors for FMLP and the cytosolic‐free calcium response of cells were measured. Results Nitrous oxide depresses C5a‐ or FMLP‐induced generation of reactive oxygen derivatives in a concentration‐dependent manner. However, the response with direct activation of protein kinase C was unaffected. Further, the number of FMLP receptors and the cytosolic calcium response were unaffected. Inhibition of the oxidative response was not reversible within the observation period of 4 h. Conclusions Nitrous oxide inhibited the intracellular signaling of the investigated G‐protein‐coupled receptors for chemotactic peptides. No interference of nitrous oxide with reduced nicotinamide adenine dinucleotide phosphate oxidase, the oxidative enzyme system of neutrophils, nor with its activation through protein kinase C was detected.
Impediments to the Effective Use of Ballistics Imaging Information In Criminal Investigations: Lessons from the Use of IBIS in a Developing Nation

ABSTRACT We use a case study approach to explore the facilitators and impediments to effectively using forensics ballistics imaging technology to improve police investigations in a developing country. The study site, Trinidad and Tobago, a nation located in the Caribbean basin, was experiencing a homicide epidemic during the time of this study. The homicide epidemic involved the repeated use of a limited number of firearms, conditions that are ideal for ballistics imaging technology. This nation also possessed a professionalized forensic crime lab and advanced ballistic imaging technology. The analysis reveals that the effective use of ballistics imaging was impeded by inefficient processes and backlogs at the national crime lab, time delays in identifying ballistics hits, and an inefficient system of transmitting hit reports to police investigators. In sum, organizational arrangements in the forensic crime lab and police in the focal country blunted the effectiveness of a proven forensic technology.
Change of Diet, Plasma Lipids, Lipoproteins, and Fatty Acids during Ramadan: A Controversial Association of the Considered Ramadan Model with Atherosclerosis Risk

Different Islamic populations have different alimentary habits, notably during Ramadan. The paper reports the change of diet, lipids, and lipoproteins produced during Ramadan in one Tunisian population. During Ramadan, the study subjects consumed more proteins, cholesterol, vitamin E (p<0.01), and polyunsaturated fatty acids (p<0.05). At the same time, they exhibited an increase in total cholesterol, low-density lipoprotein-cholesterol (p<0.01) and apoprotein B (p<0.05) and a decrease in the ratio of apoprotein AI to apoprotein B (p<0.01). All assayed saturated fatty acids were unaffected by Ramadan fasting while three unsaturated fatty acids (C18:1cis9, C18:2n-6, and C30:4n-6) increased significantly. A return to the habitual diet for a four-week period was not sufficient to restore the pre-fasting patterns. For the study subjects, Ramadan was clearly associated with a change of diet and biochemical profile but its effective impact on atherosclerosis risk was unclear, perhaps, because other non-alimentary changes ought to be considered too. Future studies considering the non-alimentary factors, such as sleep and physical activity, would be useful to clarify the contribution of dietary change in the observed modification of biological profile.
Vaspin Increases Nitric Oxide Bioavailability through the Reduction of Asymmetric Dimethylarginine in Vascular Endothelial Cells

Vaspin is an adipocytokine recently identified in the visceral adipose tissue of diabetic rats and having anti-diabetic effects. We have recently shown that vaspin has anti-atherogenic effect through Akt-mediated inhibition of endothelial cell apoptosis. Decreased activity of endothelial nitric oxide synthase (eNOS) plays an important role in the pathogenesis of atherosclerosis. Asymmetric dimethylarginine (ADMA) is a well-known endogenous competitive inhibitor of eNOS and risk factor of cardiovascular diseases. The aim of this study was to examine whether vaspin might protect against atherosclerosis through its beneficial effects on the ADMA-eNOS system. Treatment of vaspin significantly increased NO secretion from endothelial cells and isolated aorta from Sprague-Dawley (SD) rats. Furthermore, treatment of vaspin prevented fatty acid-induced decrease in endothelium-dependent vasorelaxation in isolated aorta of SD rat. For the mechanism of vaspin-induced NO biosynthesis, vaspin activated the STAT3 signaling pathway and stimulated eNOS phosphorylation (Ser 1177), a marker of eNOS activation, through STAT3-dependent mechanism. Furthermore, vaspin treatment increased the expression of dimethylarginine dimethylaminohydrolase (DDAH) II, the responsible enzyme for the degradation of ADMA, leading to a reduction in ADMA levels. Vaspin-induced increase in DDAH II gene expression was through STAT3-mediated stimulation of DDAH II promoter activity. These results suggest that vaspin increases eNOS activity by reducing ADMA level through STAT3-mediated regulation of DDAH II expression. Our findings provide a novel molecular mechanism of antiatherogenic actions of vaspin.
Information asymmetry in process consultation

Purpose – The purpose of this paper is to revisit Schein’s proposed process-consultation approach as a general framework for management consulting in the light of some premises of the agency theory, namely the behavior induced by the asymmetry of information between the principal (leader-client) and the agent (consultant). Design/methodology/approach – Empirical research consisted of an in-depth, qualitative and phenomenological analysis of 13 cases of organizational intervention based on the practice of four senior consultants in a Canadian management consulting firm whose philosophy is based on organizational development principles and practices. All the cases chosen are characterized by a situation of strategic change as a result of governmental reforms in the healthcare sector between 2005 and 2008. Findings – Overall, the study shows that the relationship between leaders-clients and consultants varies from one stage to another throughout the consultation process and that the information asymmetry doe.
A 0.8-V 110-nA CMOS current reference circuit using subthreshold operation

This paper proposes a low voltage CMOS nano-ampere current reference circuit and presents its performance with circuit simulations in 180-nm technology. The proposed circuit consists of biasvoltage, current-source and offset-voltage sub-circuits with most of MOSFETs operating in subthreshold region. Simulation results show that the circuit generates a stable reference current of 110-nA in supply voltage range of 0.8–1.8-V with line sensitivity of 9250 ppm/V. The proposed circuit is useful for composing a voltage reference circuit for ultra-low power applications.
Modulation of the reactivity of the guinea‐pig isolated trachealis by respiratory epithelium: Effects of cooling

1 Examination has been made of the effects of epithelium removal on the reactivity of guinea‐pig trachealis to methacholine at 37°C and 22°C, and on responses to activation of the Na+/K+‐pump by abrupt temperature increase from 22°C to 37°C. 2 At 37°C, epithelium removal increased the sensitivity of isolated tracheal strips to methacholine without affecting the maximum isometric contractile response. Epithelium removal resulted at 22°C in a decrease in sensitivity to methacholine, i.e. an effect opposite to that seen at 37°C. While the maximum response of intact strips to methacholine was enhanced at 22°C, the maximum response of denuded preparations was decreased. 3 The increase in sensitivity to methacholine at 37°C after epithelium removal was mimicked in intact preparations by indomethacin (1 μm). Indomethacin did not mimic the decrease in methacholine sensitivity and maximum response caused by epithelium removal at 22°C. 4 Following incubation at 22°C, abrupt increase in temperature to 37°C elicited relaxation in both epithelium‐containing and epithelium‐denuded tracheal strips. In epithelium‐containing preparations the relaxation was more pronounced and followed by contraction. Ouabain (1 μm) converted the relaxation of denuded preparations to contraction, but was ineffective in intact strips. The relaxation of intact strips was, however, inhibited by a greater ouabain concentration (10 μm). 5 These findings indicate that the modulatory effect of the epithelium is temperature‐dependent. In cooled preparations, the epithelium enhances reactivity. At 37°C, an epithelium‐derived factor reduces reactivity, and this may partially be due to activation of the electrogenic Na+/K+‐pump.