Miracle-dz/UniFAR-FTUs huggingface dataset:
Mobile Data Offloading Through Caching in Residential 802.11 Wireless Networks

As the ever growing mobile data traffic challenges the economic viability and performance of cellular networks, innovative solutions that harvest idle user-owned network resources are gaining increasing interest. In this work, we propose leasing wireless bandwidth and cache space of residential 802.11 (WiFi) access points (APs) for offloading mobile data. This solution not only reduces cellular network congestion, but, due to caching, improves also the user-perceived network performance without overloading the backhaul links of the APs. To encourage residential users to contribute their bandwidth and cache resources, we design monetary incentive (reimbursement) schemes. The offered reimbursements directly determine the amounts of available bandwidth and cache space in every AP, which in turn affect the caching policy (where to cache each content file) and the routing policy (where to route each mobile data request). In order to reduce operator's total cost for serving mobile data requests and leasing resources, we introduce a framework for the joint optimization of incentive, caching, and routing policies. Using a novel WiFi usage dataset collected from 167 residences, we show that in densely populated areas with relatively costly network capacity upgrades, our proposal can halve operator's total cost, while reimbursing up to 9€ per month each residential user.
The 3D folding of metazoan genomes correlates with the association of similar repetitive elements

The potential roles of the numerous repetitive elements found in the genomes of multi-cellular organisms remain speculative. Several studies have suggested a role in stabilizing specific 3D genomic contacts. To test this hypothesis, we exploited inter-chromosomal contacts frequencies obtained from Hi-C experiments and show that the folding of the human, mouse and Drosophila genomes is associated with a significant co-localization of several specific repetitive elements, notably many elements of the SINE family. These repeats tend to be the oldest ones and are enriched in transcription factor binding sites. We propose that the co-localization of these repetitive elements may explain the global conservation of genome folding observed between homologous regions of the human and mouse genome. Taken together, these results support a contribution of specific repetitive elements in maintaining and/or reshaping genome architecture over evolutionary times.
Integral Event-Triggered Formation Control for General Linear Multi-Agent Systems

In this paper, to solve the formation control problem, we focus on an integral event-triggered control with an undirected topology graph which is connected. Considering the classical general linear multi-agent systems, the agents could achieve the expected formation from initial positions and the larger average inter-event intervals would be yielded by using the integral event-triggered mechanism. Moreover, we demonstrate that the Zeno behaviors could be strictly avoided by gaining the positive lower bound between two triggering inter-event intervals. Finally, the numerical simulations show that the proposed event-triggered strategy is effective.
DNA replication in the fission yeast: robustness in the face of uncertainty

DNA replication, the process of duplication of a cell's genetic content, must be carried out with great precision every time the cell divides, so that genetic information is preserved. Control mechanisms must ensure that every base of the genome is replicated within the allocated time (S‐phase) and only once per cell cycle, thereby safeguarding genomic integrity. In eukaryotes, replication starts from many points along the chromosome, termed origins of replication, and then proceeds continuously bidirectionally until an opposing moving fork is encountered. In contrast to bacteria, where a specific site on the genome serves as an origin in every cell division, in most eukaryotes origin selection appears highly stochastic: many potential origins exist, of which only a subset is selected to fire in any given cell, giving rise to an apparently random distribution of initiation events across the genome. Origin states change throughout the cell cycle, through the ordered formation and modification of origin‐associated multisubunit protein complexes. State transitions are governed by fluctuations of cyclin‐dependent kinase (CDK) activity and guards in these transitions ensure system memory. We present here DNA replication dynamics, emphasizing recent data from the fission yeast Schizosaccharomyces pombe, and discuss how robustness may be ensured in spite of (or even assisted by) system randomness. Copyright © 2006 John Wiley & Sons, Ltd.
Gençlerin Beslenme Bilgi, Alışkanlık ve Davranışları İle Beden Kütle İndeksleri Arasındaki İlişki

Determination of relation between nutritional knowledge, habits and behaviors of youths and their body mass indexes, a questionnaire was applied to 1340 students and also their body mass indexes were calculated. Nutrition habits, behaviors and knowledge scores were evaluated according to the body mass index and gender. It is determined that the girls nutritional habit, behavior and knowledge scores are higher than boys, this difference is statistically significant (p<0.05). Although there is a difference between body mass indexes, it isn\'t statistically significant. As a result, it is thought that to turn knowledge into behaviors, continual nutrition trBeslenme Bilgisi, Beslenme Aliskanligi, Beden Kutle IndeksiNutritional Knowledge, Nutritional Habit, Body Mass Index Tam Metin Arsiv Yil :2014 Cilt :34 No:2Yil :2014 Cilt :34 No:1Yil :2013 Cilt :33 No:3Yil :2013 Cilt :33 No:2Yil :2013 Cilt :33 No:1Yil :2012 Cilt :32 No:3Yil :2012 Cilt :32 No:2Yil :2012 Cilt :32 No:1Yil :2011 Cilt :31 No:3Yil :2011 Cilt :31 No:2Yil :2011 Cilt :31 No:1Yil :2010 Cilt :30 No:3Yil :2010 Cilt :30 No:2Yil :2010 Cilt :30 No:1Yil :2009 Cilt :29 No:3Yil :2009 Cilt :29 No:2Yil :2009 Cilt :29 No:1Yil :2008 Cilt :28 No:3Yil :2008 Cilt :28 No:2Yil :2008 Cilt :28 No:1Yil :2007 Cilt :27 No:3Yil :2007 Cilt :27 No:2Yil :2007 Cilt :27 No:1Yil :2006 Cilt :26 No:3Yil :2006 Cilt :26 No:2Yil :2006 Cilt :26 No:1Yil :2005 Cilt :25 No:3Yil :2005 Cilt :25 No:2Yil :2005 Cilt :25 No:1Yil :2004 Cilt :24 No:3Yil :2004 Cilt :24 No:2Yil :2004 Cilt :24 No:1Yil :2003 Cilt :23 No:3Yil :2003 Cilt :23 No:2Yil :2003 Cilt :23 No:1Yil :2002 Cilt :22 No:3Yil :2002 Cilt :22 No:2Yil :2002 Cilt :22 No:1Yil :2001 Cilt :21 No:3Yil :2001 Cilt :21 No:2Yil :2001 Cilt :21 No:1
Entrectinib: a potent new TRK, ROS1, and ALK inhibitor

Introduction: Receptor tyrosine kinases (RTKs) and their signaling pathways, control normal cellular processes; however, their deregulation play important roles in malignant transformation. In advanced non-small cell lung cancer (NSCLC), the recognition of oncogenic activation of specific RTKs, has led to the development of molecularly targeted agents that only benefit roughly 20% of patients. Entrectinib is a pan-TRK, ROS1 and ALK inhibitor that has shown potent anti-neoplastic activity and tolerability in various neoplastic conditions, particularly NSCLC. Areas covered: This review outlines the pharmacokinetics, pharmacodynamics, mechanism of action, safety, tolerability, pre-clinical studies and clinical trials of entrectinib, a promising novel agent for the treatment of advanced solid tumors with molecular alterations of Trk-A, B and C, ROS1 or ALK. Expert opinion: Among the several experimental drugs under clinical development, entrectinib is emerging as an innovative and promising targeted agent. The encouraging antitumor activity reported in the Phase 1 studies, together with the acceptable toxicity profile, suggest that entrectinib, thanks to its peculiar mechanism of action, could play an important role in the treatment-strategies of multiple TRK-A, B, C, ROS1, and ALK- dependent solid tumors, including NSCLC and colorectal cancer. That being said, further evidence for its clinical use is still needed.
Phase II Study of Feasibility of Dose-Dense FEC Followed by Alternating Weekly Taxanes in High-Risk, Four or More Node-Positive Breast Cancer

Purpose: To develop a potentially superior adjuvant chemotherapy regimen, we conducted a pilot study of dose-dense 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) followed by weekly alternating taxanes. The primary objective was to determine the feasibility of the regimen; the secondary objective was to estimate the disease-free and overall survival. Experimental Design: Patients with ≥4 node-positive breast cancer were studied. Treatment consisted of FEC at 500/100/500 mg/m2, respectively, ×6 at two-week intervals with granulocyte colony-stimulating factor, followed by weekly paclitaxel (80 mg/m2) alternating with docetaxel (35 mg/m2) ×18. Results: Between November 2001 and January 2003, 44 patients were enrolled. Median age was 46 years (range, 26–63 years), median number of positive nodes was 9 (range, 4–32), and median tumor size was 2.5 cm (range, 0.6–11.0 cm). Because of unexpected toxicities, the study was stopped when 17 (39%) had fully completed all of the planned treatment. Two of 17 (12%) developed grade 4 pericardial/grade 3 bilateral pleural effusions at treatment completion; both required pericardial window. The remaining patients were treated with taxanes using one of several standard dose and schedule combinations. Furthermore, 4 of 44 (9%) developed pneumonitis attributed to the FEC regimen. Hospital admissions were required for 12 of 44 (27%); 3 of 44 (7%) required blood transfusions. There were no treatment related deaths. Median disease-free and overall survival will not be estimatable because of early closure of study. Conclusion: FEC ×6 at 2-week intervals followed by 18 weeks of alternating taxanes is not feasible at the doses tested. Other strategies are needed to improve adjuvant systemic chemotherapy.
Details Extraction of Non-Standard License Plates Including Arabic and Indian Digits

This article details the development of a new solution specifically tailored for the extraction of information from non-standard license plates, encompassing the recognition of Arabic and Indian numerical characters. The system operates in three distinct stages: cleansing, segmentation, and recognition. the system is capable of identifying irregularities in license plates such as blurred or missing numbers.
The History of Research on Father Involvement

SUMMARY Both our understanding and operationalization of fatherhood and father involvement have changed over time. Fatherhood has always been a multifaceted concept, although over time the dominant or defining motif has shifted in turn from moral guidance to breadwinning to sex-role modeling, marital support, and finally nurturance. As a result of these changing concepts, the extent of father involvement has been viewed and indexed in different ways at different times. In the late 1960s and early 1970s, at a time when societal concerns about the effects of fatherlessness were coming to the fore, social scientists also became much more interested in quantification of concepts such as father involvement, motivated in part by the emergence and popularity of time-use methodologies. This prompted a shift from a focus on qualitative dimensions (such as masculinity and dominance) to quantifiable dimensions (the amount of time spent by fathers with their children). This led to a restricted focus on paternal nurturance with little if any attention paid to the other functions or aspects of fatherhood. The narrowly focused view of fatherhood that resulted, ignored subcultural variation in the definition and understanding of fatherhood. Social scientists are only now beginning to seek a broader and more inclusive understanding of fatherhood-efforts that should permit more insightful research on the effects of variations in performance of the relevant roles.
Extending ACID semantics to the file system

An organization's data is often its most valuable asset, but today's file systems provide few facilities to ensure its safety. Databases, on the other hand, have long provided transactions. Transactions are useful because they provide atomicity, consistency, isolation, and durability (ACID). Many applications could make use of these semantics, but databases have a wide variety of nonstandard interfaces. For example, applications like mail servers currently perform elaborate error handling to ensure atomicity and consistency, because it is easier than using a DBMS. A transaction-oriented programming model eliminates complex error-handling code because failed operations can simply be aborted without side effects. We have designed a file system that exports ACID transactions to user-level applications, while preserving the ubiquitous and convenient POSIX interface. In our prototype ACID file system, called Amino, updated applications can protect arbitrary sequences of system calls within a transaction. Unmodified applications operate without any changes, but each system call is transaction protected. We also built a recoverable memory library with support for nested transactions to allow applications to keep their in-memory data structures consistent with the file system. Our performance evaluation shows that ACID semantics can be added to applications with acceptable overheads. When Amino adds atomicity, consistency, and isolation functionality to an application, it performs close to Ext3. Amino achieves durability up to 46% faster than Ext3, thanks to improved locality.
Photolysis of N-hydroxpyridinethiones: a new source of hydroxyl radicals for the direct damage of cell-free and cellular DNA.

N-Hydroxypyridine-2-thione (2-HPT), known to release hydroxyl radicals on irradiation with visible light, and two related compounds, viz. N-hydroxypyridine-4-thione (4-HPT) and N-hydroxyacridine-9-thione (HAT), were tested for their potency to induce DNA damage in L1210 mouse leukemia cells and in isolated DNA from bacteriophage PM2. DNA single-strand breaks and modifications sensitive to various repair endonucleases (Fpg protein, endonuclease III, exonuclease III, T4 endonuclease V) were quantified. Illumination of cell-free DNA in the presence of 2-HPT and 4-HPT gave rise to damage profiles characteristic for hydroxyl radicals, i.e. single-strand breaks and the various endonuclease-sensitive modifications were formed in the same ratios as after exposure to established hydroxyl radical sources. In contrast, HAT plus light gave rise to a completely different DNA damage profile, namely that characteristic for singlet oxygen. Experiments with various scavengers (t-butanol, catalase, superoxide dismutase) and in D2O as solvent confirmed that hydroxyl radicals are directly responsible for the DNA damage caused by photoexcited 2-HPT and 4-HPT, while the damage by HAT plus light is mediated by singlet oxygen and type I reactions. The type of DNA damage characteristic of hydroxyl radicals was also observed in L1210 mouse leukemia cells when treated with 2-HPT plus light or with H2O2 at 0 degrees C. t-Butanol (2%) inhibited the cellular DNA damage by approximately 50%. A dose of 2-HPT plus light that generated single-strand breaks at a frequency of 5 x 10(-7)/bp was associated with 50% cell survival. No DNA damage and cytotoxicity was observed after treatment with 2-HPT in the dark. We propose that 2-HTP and 4-HTP may serve as new agents to study the consequences of DNA damage induced by hydroxyl radicals in cells. In addition, the data provide direct evidence that hydroxyl radicals are ultimately responsible for the genotoxic effects caused by H2O2 in the dark.
Characterization of the Arabidopsis thaliana Interactome Targeted by Viruses

SFI Working Papers contain accounts of scientific work of the author(s) and do not necessarily represent the views of the Santa Fe Institute. We accept papers intended for publication in peer-reviewed journals or proceedings volumes, but not papers that have already appeared in print. Except for papers by our external faculty, papers must be based on work done at SFI, inspired by an invited visit to or collaboration at SFI, or funded by an SFI grant. ©NOTICE: This working paper is included by permission of the contributing author(s) as a means to ensure timely distribution of the scholarly and technical work on a non-commercial basis. Copyright and all rights therein are maintained by the author(s). It is understood that all persons copying this information will adhere to the terms and constraints invoked by each author's copyright. These works may be reposted only with the explicit permission of the copyright holder. www.santafe. edu
Decreased serum levels of adiponectin are a risk factor for the progression to type 2 diabetes in the Japanese Population: the Funagata study.

OBJECTIVE To examine whether decreased serum levels of adiponectin are an independent risk factor for the progression to type 2 diabetes in a Japanese population. RESEARCH DESIGN AND METHODS The serum levels of adiponectin and tumor necrosis factor-alpha (TNF-alpha) at baseline (from 1995 to 1997) were evaluated in 1,792 individuals (1,023 women and 769 men, aged 58.5 +/- 12.5 years) from a cohort population (n = 3,706) of the Funagata study. Glucose tolerance was evaluated at baseline and also at 5-year follow-up examinations (n = 978, follow-up rate, 54.6%) according to the 1985 World Health Organization criteria. The correlation of clinical traits with serum levels of adiponectin was examined. The association of the traits with the progression to type 2 diabetes at the 5-year follow-up was also examined. RESULTS Among the traits examined, the correlation with aging was highest (r = 0.312, P < 0.001). Eighteen subjects with normal glucose tolerance (NGT) developed diabetes, and 709 remained NGT at the 5-year follow-up examinations. The subjects who became diabetic had decreased serum levels of adiponectin (7.29 +/- 2.35 vs. 9.13 +/- 2.35 10 x log microg/ml, P = 0.009). Multiple logistic regression analysis with age, sex, waist-to-hip ratio, and 2-h plasma glucose as the variables revealed that serum adiponectin level (odds ratio [per 0.1 log microg/ml] 0.766, P = 0.029) was an independent risk factor for the progression to type 2 diabetes. The subjects whose serum levels of adiponectin were in the lowest tertile were 9.320 times (95% CI 1.046-83.1) more likely to develop diabetes than those in the highest tertile (P = 0.046). CONCLUSIONS Decreased serum adiponectin level is an independent risk factor for progression to type 2 diabetes.
A Study of Various Graphical Passwords Authentication Schemes Using Ai Hans Peter Wickelgren Approach

Using AI Hans peter Wickelgren applying the usage of text-based passwords is common authentication system in any Application. This conventional authentication scheme faces some kind of limitations and drawbacks with usability and crypto-graphical security issues that bring troubles to users. For example, user tends to pick passwords that can be easily guessed. On the contrary, if a password is hard to guess, then it is often hard to remember. An alternative system is required to overcome these problems. To deal with these drawbacks, authentication scheme that use photo ,image, or set of pattern as password is proposed using knowledge Recall-Based System(KRBS). Graphical passwords consist of clicking or dragging activities on the pictures rather than typing textual characters, might be the option to overcome the problems that arise from the text-based passwords authentication system. In this paper, a comprehensive Artificial Intelligence(AI) study of the existing graphical password schemes is performed. The graphical password authentication systems are categorized into two AI approach types: An approach on recognition-based System (RBS) and second approach on Recall-based system (RCBS). We discuss adequately the strengths and limitations of each method in terms of usability and security aspects . Keywords- Graphical Passwords using Hans peter Wickelgren, Recognition-Based Graphical User Authentication, Recall-Based Graphical User Authentication, Pure Recall-Based Authentication, Knowledge Recall-Based Authentication System, Usability, Security , Artificial Intelligence(AI) ,Knowledge-Based Development Systems(KBDS).
Attitude Tracking Control of Liquid- Filled Spacecraft Based on Internal Model

This paper studies the attitude tracking problem of liquid-filled spacecraft with time-varying inertial matrix and unmodeled input disturbances. First we establish the attitude error system of liquid-filled sapceraft based on quaternions. Aiming at the dynamic characters of the system, a linear time-varying internal model is designed. After we attach the internal model to the original system and get the augmented system, a dynamic high-gain controller is designed to ensure the input-to-state stability (ISS) property of the closed-loop system. Simulation verifies the robustness and accuracy of the proposed controller.
PGRMC1 Elevation in Multiple Cancers and Essential Role in Stem Cell Survival

Cancer is one of the leading causes of death in America, and there is an urgent need for new therapeutic approaches. The progesterone receptor membrane component 1 (PGRMC1) is a cytoch-rome b5 related protein that binds heme and is associated with signaling, apoptotic suppression and autophagy. PGRMC1 is essential for tumor formation, invasion and metastasis, and is upregulated in breast, colon, lung and thyroid tumors. In the present study, we have analyzed PGRMC1 levels in over 600 tumor sections, including a larger cohort of lung tumors than in previous studies, and report the first clinical analysis of PGRMC1 levels in human oral cavity and ovarian tumors compared to corresponding nonmalignant tissues. PGRMC1 was highly expressed in lung and ovarian cancers and correlated with patient survival. PGRMC1 has been previously associated with drug resistance, a characteristic of cancer stem cells. The stem cell theory proposes that a subset of cancerous stem cells contribute to drug resistance and tumor maintenance, and PGRMC1 was detected in lung-tumor derived stem cells. Drug treatment with a PGRMC1 inhibitor, AG-205, triggered stem cell death whereas treatment with erlotinib and the ERK inhibitor, PD98059, did not, suggesting a specific role for PGRMC1 in cancer stem cell viability. Together, our data demonstrate PGRMC1 as a potential tumor biomarker across a variety of tumors, as well as a therapeutic target for cancer stem cells.
Automated cross layer feature selection for effective intrusion detection in networked systems

Traditionally, anomaly detection mechanisms have relied on the inspection of certain manually (by domain experts) chosen features in order to determine if a networked system is under attack or not. Unfortunately, the approach, while somewhat effective in flagging known attacks, yields either low true positive rates or high false positive rates when the attacks are mutated slightly or in the presence of zero day attacks. One can traditionally gather a lot of data at different layers (packet contents, application logs, OS behaviors, etc.) as evidence that could be used for intrusion detection. However, it is not easy to determine which of these evidence vectors or features are useful in facilitating highly accurate intrusion detection. In this paper, we undertake an in-depth experimental study to determine whether appropriately trained search algorithms can help us find the right set of features for detecting a class of attacks (e.g., denial of service). The output of such algorithms yields a set of features that should potentially improve detection accuracy. Towards this we monitor 365 features across system layers and compare the detection performance of 3 popular feature selection algorithms to reduce the state space of the feature set for two classes of attacks. We find that the approach can yield significantly improved detection accuracy in comparison to statically chosen single features, sub or super sets of features of what the algorithms yield.