Miracle-dz/UniFAR-FTUs huggingface dataset:
The ADMM Penalized Decoder for LDPC Codes

Linear programming (LP) decoding for low-density parity-check codes was introduced by Feldman et al. and has been shown to have theoretical guarantees in several regimes. Furthermore, it has been reported in the literature-via simulation and via instanton analysis-that LP decoding displays better error rate performance at high signal-to-noise ratios (SNR) than does belief propagation (BP) decoding. However, at low SNRs, LP decoding is observed to have worse performance than BP. In this paper, we seek to improve LP decoding at low SNRs while maintaining LP decoding's high SNR performance. Our main contribution is a new class of decoders obtained by applying the alternating direction method of multipliers (ADMM) algorithm to a set of non-convex optimization problems. These non-convex problems are constructed by adding a penalty term to the objective of LP decoding. The goal of the penalty is to make pseudocodewords, which are non-integer vertices of the LP relaxation, more costly. We name this class of decoders-ADMM penalized decoders. For low and moderate SNRs, we simulate ADMM penalized decoding with ℓ1 and ℓ2 penalties. We find that these decoders can outperform both BP and LP decoding. For high SNRs, where it is difficult to obtain data via simulation, we use an instanton analysis and find that, asymptotically, ADMM penalized decoding performs better than BP but not as well as LP. Unfortunately, since ADMM penalized decoding is not a convex program, we have not been successful in developing theoretical guarantees. However, the non-convex program can be approximated using a sequence of linear programs; an approach that yields a reweighted LP decoder. We show that a two-round reweighted LP decoder has an improved theoretical recovery threshold when compared with LP decoding. In addition, we find via simulation that reweighted LP decoding significantly attains lower error rates than LP decoding at low SNRs.
The Most Prevalent Freeman-Sheldon Syndrome Mutations in the Embryonic Myosin Motor Share Functional Defects*

The embryonic myosin isoform is expressed during fetal development and rapidly down-regulated after birth. Freeman-Sheldon syndrome (FSS) is a disease associated with missense mutations in the motor domain of this myosin. It is the most severe form of distal arthrogryposis, leading to overcontraction of the hands, feet, and orofacial muscles and other joints of the body. Availability of human embryonic muscle tissue has been a limiting factor in investigating the properties of this isoform and its mutations. Using a recombinant expression system, we have studied homogeneous samples of human motors for the WT and three of the most common FSS mutants: R672H, R672C, and T178I. Our data suggest that the WT embryonic myosin motor is similar in contractile speed to the slow type I/β cardiac based on the rate constant for ADP release and ADP affinity for actin-myosin. All three FSS mutations show dramatic changes in kinetic properties, most notably the slowing of the apparent ATP hydrolysis step (reduced 5–9-fold), leading to a longer lived detached state and a slowed Vmax of the ATPase (2–35-fold), indicating a slower cycling time. These mutations therefore seriously disrupt myosin function.
Germany SPIROS- A SYSTEM FOR PRIVACY-ENHANCED INFORMATION REPRESENTATION IN SMART HOME ENVIRONMENTS

This paper presents a novel concept for personalized privacy support on large public displays in intelligent home environments. In order to validate the conceptual approach a system called SPIROS was developed. The SPIROS system automatically adapts the information visible on public displays according to the current social situation and the individual privacy preferences of the user working at the display. Copyright © 2006 USTARTH
A ferry making waves: A demonstration project ‘doing’ institutional work in a greening maritime industry

ABSTRACT The objective of the article is to show how the demonstration project and battery ferry Ampere has contributed to a greening of public ferry procurement in Norway. Building on theories on demonstration projects in transition studies and institutional work, the author argues for a more integrated focus than hitherto on the dynamic interplay of materiality, organization, and discourse in demonstration projects, and how the agency of actor networks and the materiality connected to demonstration projects can affect institutional change accompanying transition processes. This is done by conceptualizing Ampere as a ‘performing project’: a complex of discursive and organizational strategies of framing and lobbying deployed by the actor networks connected to it and its materiality. Methodically, the author draws on semi-structured interviews and document analysis. The results suggest that Ampere’s ‘performance’ has contributed to changes in national and regional ferry procurement practices and been vital for an emerging maritime battery niche.
Making Progressive Transmission Adaptive

Progressive transmission hierarchically reorganizes the information in an image with the aim of increasing transmission efficiency on a low bandwidth channel. We have developed methods for adaptively choosing initial and successive approximations to be sent when the end user is a human telebrowsing through a database to find particular desired images. Because of progressive transmission overhead, it is desirable to send in one step the approximation which is just good enough to allow a user to make a positive decision (e.g., want/don't want). During past and present sessions of telebrowsing, positive response times are recorded and used to estimate the actual positive response time probability mass function. This estimate is used with a previously calculated overhead function to choose the best initial and successive approximations. We discuss the application of two-channel coding to progressive transmission and conclude that little is gained by further coding of the initial lowresolution approximation. However, the interpretation of these lowresolution images is enhanced if the displayed size is a function of image resolution. We present a method for determination of the best displayed image size which is based on the modulation transfer function of the human visual system.
IT Infrastructure Components for Biobanking

Summary Objective: Within translational research projects in the recent years large biobanks have been established, mostly supported by homegrown, proprietary software solutions. No general requirements for biobanking IT infrastructures have been published yet. This paper presents an exemplary biobanking IT architecture, a requirements specification for a biorepository management tool and exemplary illustrations of three major types of requirements. Methods: We have pursued a comprehensive literature review for biobanking IT solutions and established an interdisciplinary expert panel for creating the requirements specification. The exemplary illustrations were derived from a requirements analysis within two university hospitals. Results: The requirements specification comprises a catalog with more than 130 detailed requirements grouped into 3 major categories and 20 subcategories. Special attention is given to multitenancy capabilities in order to support the project-specific definition of varying research and bio-banking contexts, the definition of workflows to track sample processing, sample transportation and sample storage and the automated integration of preanalytic handling and storage robots. Conclusion: IT support for biobanking projects can be based on a federated architectural framework comprising primary data sources for clinical annotations, a pseudonymization service, a clinical data warehouse with a flexible and user-friendly query interface and a biorepository management system. Flexibility and scalability of all such components are vital since large medical facilities such as university hospitals will have to support biobanking for varying monocentric and multicentric research scenarios and multiple medical clients.
Understanding Iodine Chemistry Over the Northern and Equatorial Indian Ocean

Observations of halogen oxides, ozone, meteorological parameters, and physical and biogeochemical water column measurements were made in the Indian Ocean and its marine boundary layer as a part of the Second International Indian Ocean Expedition (IIOE‐2). The expedition took place on board the oceanographic research vessel Sagar Nidhi during 4–22 December 2015 from Goa, India, to Port Louis, Mauritius. Observations of mixed layer depth, averaged temperature, salinity, and nitrate concentrations were used to calculate predicted iodide concentrations in the seawater. The inorganic iodine ocean‐atmosphere flux (hypoiodous acid [HOI] and molecular iodine [I2]) was computed using the predicted iodide concentrations, measured atmospheric ozone, and wind speed. Iodine oxide (IO) mixing ratios peaked at 0.47 ± 0.29 pptv (parts per trillion by volume) in the remote open ocean environment. The estimated iodide concentrations and HOI and I2 fluxes peaked at 200/500 nM, 410/680 nmol·m−2·day−1, and 20/80 nmol·m−2·day−1, respectively, depending on the parameterization used. The calculated fluxes for HOI and I2 were higher closer to the Indian subcontinent; however, atmospheric IO was only observed above the detection limit in the remote open ocean environment. We use NO2 observations to show that titration of IO by NO2 is the main reason for this result. These observations show that inorganic iodine fluxes and atmospheric IO show similar trends in the Indian Ocean marine boundary layer, but the impact of inorganic iodine emissions on iodine chemistry is buffered in elevated NOx environments, even though the estimated oceanic iodine fluxes are higher.
Calderón preconditioning techniques for integral equation based methods

Some recent advances in the Calderón preconditioning techniques for integral-equation-based methods are discussed in this paper. Four different techniques are presented briefly: a low-frequency Calderón preconditioner for the electric-field integral equation (EFIE) in analyzing perfect electric conductor (PEC) problems, an augmented EFIE (AEFIE) with Calderón preconditioner for simulating electrically large problems, several Calderón-type preconditioners for the Poggio-Miller-Chang-Harrington-Wu-Tsai (PMCHWT) equations, and the derivation of N-Müller equations using Calderón identities. A number of numerical examples are given to demonstrate the performance of the proposed approaches.
Analytical performance assessment for multi-dimensional Tensor-ESPRIT-type parameter estimation algorithms

Subspace-based high-resolution parameter algorithms such as ESPRIT, MUSIC, or RARE are known as efficient and versatile tools in various signal processing applications including radar, sonar, medical imaging, or the analysis of MIMO channel sounder measurements. Since these techniques are based on the singular value decomposition (SVD), their performance can be analyzed with the help of SVD-based perturbation theory.
Induction versus interior permanent magnet synchronous motors for positioning systems using direct flux vector control

The development of a control strategy suitable for Permanent Magnet (PM) and Induction Motor (IM) drives is considered. The proposed scheme is based on the Direct Flux Vector Control (DFVC) method, adapted for positioning systems (over azimuth and elevation). A comparative study of IM and Interior PM motors performances is presented.
CS 348 b Project : Light Field Camera Simulation

We report a simulation platform for a lightfield camera. Our methods may be applied to develop and refine future lightfield acquisition systems. Furthermore, the rendering pipeline of PBRT has been augmented to include our camera simulator, permitting the generation of refocus-able computer-generated artwork. We demonstrate our simulation platform on various imaging scenarios that may prove challenging for more conventional imaging models.
Touch-and-connect: a connection request framework for ad-hoc networks and the pervasive computing environment

The spread of short distance wireless communication technology is making it possible for various information appliances to communicate through a network. However, to connect and to use them, we must generally perform complicated setup operations such as setting addresses or names. In this paper, we propose a user-friendly connecting management framework called " Touch-and-Connect". With this method, we can connect any networked devices only by touching them. This system is designed so that it can work without a server and even if many individuals operate it independently, no incorrect connections occur. And we have exemplified the usefulness of this framework with subject experiments.
Mobile medical and health apps: state of the art, concerns, regulatory control and certification

This paper examines the state of the art in mobile clinical and health-related apps. A 2012 estimate puts the number of health-related apps at no fewer than 40,000, as healthcare professionals and consumers continue to express concerns about the quality of many apps, calling for some form of app regulatory control or certification to be put in place. We describe the range of apps on offer as of 2013, and then present a brief survey of evaluation studies of medical and health-related apps that have been conducted to date, covering a range of clinical disciplines and topics. Our survey includes studies that highlighted risks, negative issues and worrying deficiencies in existing apps. We discuss the concept of ‘apps as a medical device’ and the relevant regulatory controls that apply in USA and Europe, offering examples of apps that have been formally approved using these mechanisms. We describe the online Health Apps Library run by the National Health Service in England and the calls for a vetted medical and health app store. We discuss the ingredients for successful apps beyond the rather narrow definition of ‘apps as a medical device’. These ingredients cover app content quality, usability, the need to match apps to consumers’ general and health literacy levels, device connectivity standards (for apps that connect to glucometers, blood pressure monitors, etc.), as well as app security and user privacy. ‘Happtique Health App Certification Program’ (HACP), a voluntary app certification scheme, successfully captures most of these desiderata, but is solely focused on apps targeting the US market. HACP, while very welcome, is in ways reminiscent of the early days of the Web, when many “similar” quality benchmarking tools and codes of conduct for information publishers were proposed to appraise and rate online medical and health information. It is probably impossible to rate and police every app on offer today, much like in those early days of the Web, when people quickly realised the same regarding informational Web pages. The best first line of defence was, is, and will always be to educate consumers regarding the potentially harmful content of (some) apps.
An Optimized Hybrid Approach for Spectrum Handoff in Cognitive Radio Networks With Non-Identical Channels

Cognitive radio (CR) is a technology that aims to enhance the use of the underutilized spectrum. Spectrum handoff plays this role by allowing the unlicensed secondary users (SUs) to use the licensed frequency bands of the primary users (PUs). Moreover, it helps the SU to vacate the channel at the presence of the PU and find a suitable channel for the interrupted SU to continue his unfinished transmission. In this paper, an analytical model for the general case of non-identical channels in CR networks is introduced for both fixed and probabilistic sequence approaches for target channel selection. Moreover, a new balancing model is suggested to generate the probabilistic sequence. Both the fixed and probabilistic sequence approaches are optimized using the meta-heuristic methods of particle swarm and genetic algorithm in the seek of finding an optimal approach to minimize the extended data delivery time of the SUs. The results are based on the pre-emptive resume priority M/M/1 queueing network model and are shown for different network cases. Based on the optimization results, a fast hybrid approach is proposed and found to achieve near optimal solution.
CD133 selected stem cells from proliferating infantile hemangioma and establishment of an in vivo mice model of hemangioma.

BACKGROUND Infantile hemangioma (IH) is the most common benign tumor in children with prevalence in the face and neck. Various treatment options including oral propranolol have been described for IH, but the mechanism of drugs remains enigmatic. The aim of this study was to investigate the pathogenesis and establish a reliable in vivo model of IH which can provide platform for drug exploration. METHODS Stem cells from the proliferating hemangiomas (HemSCs) were isolated by CD133-tagged immunomagnetic beads. Their phenotype and angiogenic property were investigated by flow cytometry, culturing on Matrigel, real-time polymerase chain reaction (PCR), immunofluorescent staining and injection into BALB/c-nu mice. RESULTS HemSCs had robust ability of proliferating and cloning. The time of cells doubling in proliferative phase was 16 hours. Flow cytometry showed that HemSCs expressed mesenchymal markers CD29, CD44, but not endothelial/hematopoietic marker of CD34 and hematopoietic marker CD45. The expression of CD105 was much lower than that of the reported hemangioma derived or normal mesenchymal stem cell (MSC). Real-time PCR showed that the mRNA levels of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and matrix metalloproteinase-1 (MMP-1) of HemSCs were higher than that of neonatal human dermal fibroblasts (NHDFs) and human umbilical vein endothelial cells (HUVECs). After HemSCs were cultured on Matrigel in vitro, they formed tube-like structure in a short time (16 hours) and differentiated into endothelial cells in 7 days. After 1 - 2 weeks of implantation into immunodeficient mice, HemSCs generated glucose transporter 1 positive blood vessels. When co-injected with HUVECs, the vascularization of HemSCs was greatly enhanced. However, the single implantation of HUVECs hardly formed blood vessels in BALB/c-nu mice (P < 0.05). CONCLUSIONS HemSCs may be some kinds of primitive mesoderm derived stem cells with powerful angiogenic ability, which can recapitulate human hemangioma by co-injecting into immunodeficient mice with HUVECs.
T-Lymphocyte Subsets in Apparently Healthy Nigerian Children

Population studies showed that there are differences in T-lymphocytes subpopulation of normal children in different regions, and reference values in an area might be different from another. This study compared the values in our population with CDC and WHO reference values. Blood samples from 279 healthy, HIV-negative children <12 years of age were analysed for complete blood count, CD3+, CD4+, CD8+ counts and percentages. Except for CD8%, mean values for all parameters measured significantly decreased with age. CD4+ counts were higher in females than males, P < . 05. Using the WHO criteria, 15.9% of subjects had low total lymphocyte count and 20.6% had low CD4 count. Children <3 years had median CD4% lower than WHO normal values. Our median CD4+ counts correlated with CDC values. Values used by WHO in infants are higher than ours. We suggest that our children be assessed using CDC reference values which correlate with ours.
Chronic Lymphocytic Leukemia Presenting with Extreme Hyperleukocytosis and Thrombosis of the Common Femoral Vein

Very few case reports dealing with chronic lymphocytic leukemia (CLL) and hyperleukocytosis have been reported in the medical literature and none with venous thrombosis as a complication. Here, we describe a 73-year-old woman who presented with newly diagnosed CLL, leukostasis, and hyperleukocytosis (2000 × 10 9 /l), affecting the respiratory and nervous system. In addition, she also had deep vein thrombosis (DVT). Although hypercoagulability and thrombosis are well-described phenomena in solid tumors and in myeloproliferative neoplasms, CLL is generally not associated with an acquired coagulopathy. We hypothesize that in our patient the extreme number of circulating lymphocytes resulted in an abnormal accumulation of lymphocytes possibly causing stasis and occlusion of a larger vessel, which resolved after leukopheresis. The patient has since been successfully maintained with chemotherapy. We conclude that leukopheresis should be considered as the therapy of choice in CLL patients presenting with major complications of leukostasis.
Bioactivity of Oral Linaclotide in Human Colorectum for Cancer Chemoprevention

Guanylate cyclase C (GUCY2C) is a tumor-suppressing receptor silenced by loss of expression of its luminocrine hormones guanylin and uroguanylin early in colorectal carcinogenesis. This observation suggests oral replacement with a GUCY2C agonist may be an effective targeted chemoprevention agent. Linaclotide is an FDA-approved oral GUCY2C agonist formulated for gastric release, inducing fluid secretion into the small bowel to treat chronic idiopathic constipation. The ability of oral linaclotide to induce a pharmacodynamic response in epithelial cells of the colorectum in humans remains undefined. Here, we demonstrate that administration of 0.87 mg of oral linaclotide daily for 7 days to healthy volunteers, after oral colon preparation with polyethylene glycol solution (MoviPrep), activates GUCY2C, resulting in accumulation of its product cyclic (c)GMP in epithelial cells of the cecum, transverse colon, and distal rectum. GUCY2C activation by oral linaclotide was associated with homeostatic signaling, including phosphorylation of vasodilator-stimulated phosphoprotein and inhibition of proliferation quantified by reduced Ki67-positive epithelial cells. In the absence of the complete oral colonoscopy preparation, linaclotide did not alter cGMP production in epithelial cells of the colorectum, demonstrating that there was an effect related to the laxative preparation. These data show that the current FDA-approved formulation of oral linaclotide developed for small-bowel delivery to treat chronic idiopathic constipation is inadequate for reliably regulating GUCY2C in the colorectum to prevent tumorigenesis. The study results highlight the importance of developing a novel GUCY2C agonist formulated for release and activity targeted to the large intestine for colorectal cancer prevention. Cancer Prev Res; 10(6); 345–54. ©2017 AACR.
PKA-R1 spatially restricts Oskar expression for Drosophila embryonic patterning

Targeting proteins to specific domains within the cell is central to the generation of polarity, which underlies many processes including cell fate specification and pattern formation during development. The anteroposterior and dorsoventral axes of the Drosophila melanogaster embryo are determined by the activities of localized maternal gene products. At the posterior pole of the oocyte, Oskar directs the assembly of the pole plasm, and is thus responsible for formation of abdomen and germline in the embryo. Tight restriction of oskar activity is achieved by mRNA localization, localization-dependent translation, anchoring of the RNA and protein, and stabilization of Oskar at the posterior pole. Here we report that the type 1 regulatory subunit of cAMP-dependent protein kinase (Pka-R1) is crucial for the restriction of Oskar protein to the oocyte posterior. Mutations in PKA-R1 cause premature and ectopic accumulation of Oskar protein throughout the oocyte. This phenotype is due to misregulation of PKA catalytic subunit activity and is suppressed by reducing catalytic subunit gene dosage. These data demonstrate that PKA mediates the spatial restriction of Oskar for anteroposterior patterning of the Drosophila embryo and that control of PKA activity by PKA-R1 is crucial in this process.