Miracle-dz/UniFAR-FTUs huggingface dataset:
Galaxy activity in merging binary galaxy clusters

We present the results of a study of galaxy activity in two merging binary clusters (A168 and A1750) using the Sloan Digital Sky Survey (SDSS) data supplemented with the data in the literature. We have investigated the merger histories of A168 and A1750 by combining the results from a two-body dynamical model and X-ray data. In A168, two subclusters appear to have passed each other and to be coming together from the recent maximum separation. In A1750, two major subclusters appear to have started interaction and to be coming together for the first time. We find an enhanced concentration of the galaxies showing star formation (SF) or active galactic nuclei (AGN) activity in the region between two subclusters in A168, which were possibly triggered by the cluster merger. In A1750, we do not find any galaxies with SF/AGN activity in the region between two subclusters, indicating that two major subclusters are in the early stage of merging.
Collagen-Based Biomaterials for Tissue Engineering Applications

Collagen is the most widely distributed class of proteins in the human body. The use of collagen-based biomaterials in the field of tissue engineering applications has been intensively growing over the past decades. Multiple cross-linking methods were investigated and different combinations with other biopolymers were explored in order to improve tissue function. Collagen possesses a major advantage in being biodegradable, biocompatible, easily available and highly versatile. However, since collagen is a protein, it remains difficult to sterilize without alterations to its structure. This review presents a comprehensive overview of the various applications of collagen-based biomaterials developed for tissue engineering, aimed at providing a functional material for use in regenerative medicine from the laboratory bench to the patient bedside.
Test-Driven Development for Spreadsheet Risk Management

Spreadsheet technology is central to the functioning of the financial sector, but the spreadsheets themselves can have a high level of error that requires innovative supporting processes and tools. Several large-scale international studies conducted in response to the Enron-inspired Sarbanes-Oxley Act confirm the importance and complexity of spreadsheet systems in financial reporting, with some companies using 200+ spreadsheets in manually controlled interconnected "webs. " Unfortunately, spreadsheets frequently have an unacceptably high number of faults. Early research indicated that between 2 and 5 percent of cell formulas can be incorrect, but a more recent study found that of 50 real-world operational spreadsheets audited, 94 percent contained errors with almost 1 percent of formula cells found to be incorrect. Spreadsheet developers don't appreciate this high risk and thus use little or no formal software development processes.
IL28B Is Associated with Outcomes of Chronic HBV Infection

Purpose The role of IL28B gene variants and expression in hepatitis B virus (HBV) infections are not well understood. Here, we evaluated whether IL28B gene expression and rs12979860 variations are associated with HBV outcomes. Materials and Methods IL28B genetic variations (rs12979860) were genotyped by pyrosequencing of DNA samples from 137 individuals with chronic HBV infection [50 inactive carriers (IC), 34 chronic hepatitis B (CHB), 27 cirrhosis, 26 hepatocellular carcinoma (HCC)], and 19 healthy controls. IL28A/B mRNA expression in peripheral blood mononuclear cells was determined by qRT-PCR, and serum IL28B protein was measured by ELISA. Results Patients with IL28B C/C genotype had greater IL28A/B mRNA expression and higher IL28B protein levels than C/T patients. Within the various disease stages, compared to IC and healthy controls, IL28B expression was reduced in the CHB, cirrhosis, and HCC cohorts (CHB vs. IC, p=0.02; cirrhosis vs. IC, p=0.01; HCC vs. IC, p=0.001; CHB vs. controls, p<0.01; cirrhosis vs. controls, p<0.01; HCC vs. controls, p<0.01). When stratified with respect to serum HBV markers in the IC and CHB cohorts, IL28B mRNA and protein levels were higher in HBeAg-positive than negative individuals (p=0.01). Logistic regression analysis revealed that factors associated with high IL28B protein levels were C/C versus C/T genotype [p=0.016, odds ratio (OR)=0.25, 95% confidence interval (CI)=0.08-0.78], high alanine aminotransferase values (p<0.001, OR=8.02, 95% CI=2.64-24.4), and the IC stage of HBV infection (p<0.001). Conclusion Our data suggest that IL28B genetic variations may play an important role in long-term development of disease in chronic HBV infections.
Bayesian segmentation of laser range scan for indoor navigation

This paper presents a robust probabilistic approach based on the Bayesian estimation theory to extract and tracking line segment parameters from successive laser range scans, acquired during the evolution of a mobile robot in an indoor environment. In this methodology, a likelihood function is modelled and associated to the existence of structured objects around the robot, an uncertainty model associated to the telemetric data is derived and used to update the likelihood function. In this way, the distances to the near objects around the robot are estimated and used in the feedback loop of a sensor-based control navigation strategy. Experiments are performed using a mobile robot equiped with a 2D laser scanner device, validating the application of the Bayesian segmentation methodology in the laser-based robot navigation.
Thyroid function in a uremic rat model. Evidence suggesting tissue hypothyroidism.

The main objective of this study was to determine whether the principal abnormality of thyroid function observed in patients with chronic renal failure, low serum triiodothyronine (T(3)) concentration, causes hypothyroidism at the tissue level. A partially nephrectomized (Nx) uremic rat model was developed and the following parameters of thyroid function were assessed: serum total thyroxine (TT(4)), total T(3) (TT(3)), and thyrotropin and liver T(3) content, and activity of two thyroid hormone-dependent enzymes, mitochondrial alpha-glycerophosphate dehydrogenase (alpha-GPD) and cytosol malate dehydrogenase (MDH). The results were compared to those of intact control (C), thyroidectomized (Tx), and nephrectomized-thyroidectomized (NxTx) littermates.Results expressed as mean+/-SEM showed that Nx rats had a fivefold increase in blood urea nitrogen, (112+/-20 mg/dl in Nx, and 22+/-1 mg/dl in C) and manifested all the changes of of thyroid function observed in uremic men, including a low serum TT(3) level (30+/-7 ng/dl in Nx and 50+/-6 ng/dl in C). In the liver, T(3) was significantly reduced (18+/-2 ng/total liver in Nx and 35+/-3 ng/total liver in C) as well as the activities of alphaGPD (8.8+/-1.0 and 16.1+/-1.5 DeltaOD/min per total liver in Nx and C, respectively) and MDH (6.3+/-1.6 and 12.6+/-2.2 U/total liver in Nx and C, respectively). The reduction in liver enzyme activities correlated significantly with the decrease in T(3) content. The changes in Tx rats were as expected, showing a profound reduction in serum hormone levels, liver T(3) content, and liver enzyme activities. Serum thyrotropin was markedly elevated to 2,390+/-212 ng/ml as compared to 703+/-61 in C and 441+/-87 ng/ml in Nx rats. The NxTx rats showed the combined effects of nephrectomy and thyroidectomy; blood urea nitrogen was elevated to 203, and serum levels of TT(4), TT(3), and thyrotropin were 0.4, <10, and 2,525, respectively. Total liver T(3) and alphaGPD and MDH were strikingly low; the corresponding values were 3.5, 2.4, and 2.5. l-triiodothyronine replacement (0.4 mug/100 g body wt/d) for 4 wk in the Nx rats resulted in significant increases in liver enzyme activities, alphaGPD and MDH rose by 70 and 60% over their respective basal values without alteration in the severity of azotemia. From these data, we conclude that the reduction of liver T(3) content in the uremic rats, accompanied by a decrease in alphaGPD and MDH activity, indicates the presence of hypothyroidism at the tissue level. Restoration of enzyme activities toward normal levels after T(3) administration provided further supporting evidence that the diminution in liver enzyme activity was causally related to tissue T(3) deficiency.
Modeling Alzheimer's Disease with Induced Pluripotent Stem Cells: Current Challenges and Future Concerns

Alzheimer's disease (AD) is the most prevalent type of dementia and its pathology is characterized by deposition of extracellular β-amyloid plaques, intracellular neurofibrillary tangles, and extensive neuron loss. While only a few familial AD cases are due to mutations in three causative genes (APP, PSEN1, and PSEN2), the ultimate cause behind the rest of the cases, called sporadic AD, remains unknown. Current animal and cellular models of human AD, which are based on the Aβ and tau hypotheses only, partially resemble the familial AD. As a result, there is a pressing need for the development of new models providing insights into the pathological mechanisms of AD and for the discovery of ways to treat or delay the onset of the disease. Recent preclinical research suggests that stem cells can be used to model AD. Indeed, human induced pluripotent stem cells can be differentiated into disease-relevant cell types that recapitulate the unique genome of a sporadic AD patient or family member. In this review, we will first summarize the current research findings on the genetic and pathological mechanisms of AD. We will then highlight the existing induced pluripotent stem cell models of AD and, lastly, discuss the potential clinical applications in this field.
Who benefits the most from peer effects within ethnic group ? Empirical evidence on the South African Labour Market

This paper provides evidence that local social interactions within etnic groups may explain the puzzling variations in labour-market outcomes across individuals. Peer effects work first by creating pressure on labor-market participation, second, by conveying information about job opportunities and by raising wages. These effects differ through a selection effect : gender and ethnic groups who are less integrated in the labour market benefit more from peer effect. Finally, networks exhibit decreasing returns. The problems of endogeneity and simultaneity of local peer effects are addressed by using (i) data aggregated at the province level, (ii) the distribution of the sex of the peers' siblings as an instrumental variable and (iii) a quasi-panel data approach relying on the Hausman-Taylor estimator. The importance of social interactions in the labour market suggests that a social multiplier exists and our estimates show that any labour-market shock is magnified with an elasticity of 0.5.
Mycorrhizas influence functional traits of two tallgrass prairie species

Abstract Over the past decade, functional traits that influence plant performance and thus, population, community, and ecosystem biology have garnered increasing attention. Generally lacking, however, has been consideration of how ubiquitous arbuscular mycorrhizas influence plant allometric and stoichiometric functional traits. We assessed how plant dependence on and responsiveness to mycorrhizas influence plant functional traits of a warm‐season, C4 grass, Andropogon gerardii Vitman, and the contrasting, cool‐season, C3 grass, Elymus canadensis L. We grew both host species with and without inoculation with mycorrhizal fungi, across a broad gradient of soil phosphorus availabilities. Both host species were facultatively mycotrophic, able to grow without mycorrhizas at high soil phosphorus availability. A. gerardii was most dependent upon mycorrhizas and E. canadensis was weakly dependent, but highly responsive to mycorrhizas. The high dependence of A. gerardii on mycorrhizas resulted in higher tissue P and N concentrations of inoculated than noninoculated plants. When not inoculated, E. canadensis was able to take up both P and N in similar amounts to inoculated plants because of its weak dependence on mycorrhizas for nutrient uptake and its pronounced ability to change root‐to‐shoot ratios. Unlike other highly dependent species, A. gerardii had a high root‐to‐shoot ratio and was able to suppress colonization by mycorrhizal fungi at high soil fertilities. E. canadensis, however, was unable to suppress colonization and had a lower root‐to shoot ratio than A. gerardii. The mycorrhiza‐related functional traits of both host species likely influence their performance in nature: both species attained the maximum responsiveness from mycorrhizas at soil phosphorus availabilities similar to those of tallgrass prairies. Dependence upon mycorrhizas affects performance in the absence of mycorrhizas. Responsiveness to mycorrhizal fungi is also a function of the environment and can be influenced by both mycorrhizal fungus species and soil fertility.
Predictive Significance of Kidney Myeloid-Related Protein 8 Expression in Patients with Obesity- or Type 2 Diabetes-Associated Kidney Diseases

Background and Objective We have reported that toll-like receptor 4 (TLR4) and one of its endogenous ligands, myeloid-related protein 8 (MRP8 or S100A8), play an important role in the progression of diabetic nephropathy in mice. The aim of this study was to evaluate significance of kidney MRP8 expression in patients with obesity- or type 2 diabetes-associated kidney diseases. Methods In diabetic, obese or control subjects, MRP8 mRNA and protein expression levels in renal biopsy samples were determined by real-time RT-PCR and immunohistochemistry (n = 28 and 65, respectively), and their associations with baseline and prognostic parameters were analyzed. Effects of MRP8 upon pro-inflammatory gene expressions were examined using macrophages. Results Kidney MRP8 gene and protein expression levels were elevated in obese or diabetic groups compared to control group. Among all subjects, by univariate linear regression analysis, glomerular MRP8-positive cell count and tubulointerstitial MRP8-positive area at baseline were both, respectively, correlated not only with various known risk factors for diabetic nephropathy (such as systolic blood pressure, proteinuria and serum creatinine) but also with extent of glomerulosclerosis and tubulointerstitial fibrosis. Independent factors predicting urinary protein levels a year later were examined by multivariate analysis, and they included glomerular MRP8-positive cell count (β = 0.59, P<0.001), proteinuria (β = 0.37, P = 0.002) and systolic blood pressure (β = 0.21, P = 0.04) at baseline, after adjustment for known risk factors. MRP8 protein expression was observed in CD68-positive macrophages and atrophic tubules. In cultured mouse macrophages, MRP8 protein induced proinflammatory cytokine expressions and also triggered auto-induction of MRP8 in a TLR4-dependent manner. Conclusions Glomerular MRP8 expression appears to be associated with progression of proteinuria in obese or type 2 diabetic patients, possibly by inducing inflammatory changes in macrophages through TLR4 signaling.
Towards rapidly developing database-supported machine learning applications

The development of a big data analytics application benefits from a conceptual model that jointly represents aspects about data management as well as machine learning. We demonstrate a recently proposed method to translate a Bayesian network into a usable entity relationship model using the real world example of the TopicExplorer system. TopicExplorer is an interactive web application for text mining that uses Bayesian topic models as a core component. Further, we sketch a vision of a conceptual framework that eases machine learning specific development tasks during building big data analytics applications.
Using Syntactic Satiation toInvestigate Subject Islands

repeated exposure, which can be induced experimentally (Snyder 2000). Although the effect of changing judgments has been replicated in several studies (Hiramatsu 2000, Goodall 2005, Francom acceptability, but the result of an unbalanced experiment design (Sprouse 2009). To the extent satiation has been replicated, the results for subject island violations has been most variable. While some experimental studies have found that participants satiate on subject islands (Hiramatsu 2000, Francom 2009), others have only found marginal to no effects (Snyder 2000, Sprouse 2009). One possible explanation for the variable results with subject islands is that the subject island items used in previous studies have not been carefully controlled for predicate type, an element which has been argued to affect overall acceptability and perhaps satiation (Merchant 2001, Erteschik-Shir 2007, Kravtchenko et al 2009). In this paper, I evaluate the replication of satiation effects for whether, adjunct and 3 types of subject islands. This study uses a new method of controlling for individual variability in scale rating tasks by standardizing responses to critical items by mean response to filler items. Replicating all studies except Sprouse (2009), I find satiation effects in a balanced design for whether islands. However, unlike Hiramatsu (2000) and Francom (2009), I do not find satiation effects for any of the subject island types tested. The results are discussed in relation to possible sources of the satiation effect. The organization of the paper is as follows: in Section 2, I will describe the satiation findings in previous studies, with special attention to the subject island results. In Section 3, I describe the present study and results. In Section 4, I discuss the results and future directions for the study of syntactic satiation.
A possible neurophysiological correlate of audiovisual binding and unbinding in speech perception

Audiovisual (AV) speech integration of auditory and visual streams generally ends up in a fusion into a single percept. One classical example is the McGurk effect in which incongruent auditory and visual speech signals may lead to a fused percept different from either visual or auditory inputs. In a previous set of experiments, we showed that if a McGurk stimulus is preceded by an incongruent AV context (composed of incongruent auditory and visual speech materials) the amount of McGurk fusion is largely decreased. We interpreted this result in the framework of a two-stage “binding and fusion” model of AV speech perception, with an early AV binding stage controlling the fusion/decision process and likely to produce “unbinding” with less fusion if the context is incoherent. In order to provide further electrophysiological evidence for this binding/unbinding stage, early auditory evoked N1/P2 responses were here compared during auditory, congruent and incongruent AV speech perception, according to either prior coherent or incoherent AV contexts. Following the coherent context, in line with previous electroencephalographic/magnetoencephalographic studies, visual information in the congruent AV condition was found to modify auditory evoked potentials, with a latency decrease of P2 responses compared to the auditory condition. Importantly, both P2 amplitude and latency in the congruent AV condition increased from the coherent to the incoherent context. Although potential contamination by visual responses from the visual cortex cannot be discarded, our results might provide a possible neurophysiological correlate of early binding/unbinding process applied on AV interactions.
QSAR Study of p56lck Protein Tyrosine Kinase Inhibitory Activity of Flavonoid Derivatives Using MLR and GA-PLS

Quantitative relationships between molecular structure and p56lck protein tyrosine kinase inhibitory activity of 50 flavonoid derivatives are discovered by MLR and GA-PLS methods. Different QSAR models revealed that substituent electronic descriptors (SED) parameters have significant impact on protein tyrosine kinase inhibitory activity of the compounds. Between the two statistical methods employed, GA-PLS gave superior results. The resultant GA-PLS model had a high statistical quality (R2 = 0.74 and Q2 = 0.61) for predicting the activity of the inhibitors. The models proposed in the present work are more useful in describing QSAR of flavonoid derivatives as p56lck protein tyrosine kinase inhibitors than those provided previously.
Lymphotoxin α/β and Tumor Necrosis Factor Are Required for Stromal Cell Expression of Homing Chemokines in B and T Cell Areas of the Spleen

Mice deficient in the cytokines tumor necrosis factor (TNF) or lymphotoxin (LT) α/β lack polarized B cell follicles in the spleen. Deficiency in CXC chemokine receptor 5 (CXCR5), a receptor for B lymphocyte chemoattractant (BLC), also causes loss of splenic follicles. Here we report that BLC expression by follicular stromal cells is defective in TNF-, TNF receptor 1 (TNFR1)-, LTα- and LTβ-deficient mice. Treatment of adult mice with antagonists of LTα1β2 also leads to decreased BLC expression. These findings indicate that LTα1β2 and TNF have a role upstream of BLC/CXCR5 in the process of follicle formation. In addition to disrupted follicles, LT-deficient animals have disorganized T zones. Expression of the T cell attractant, secondary lymphoid tissue chemokine (SLC), by T zone stromal cells is found to be markedly depressed in LTα-, and LTβ-deficient mice. Expression of the SLC-related chemokine, Epstein Barr virus–induced molecule 1 ligand chemokine (ELC), is also reduced. Exploring the basis for the reduced SLC expression led to identification of further disruptions in T zone stromal cells. Together these findings indicate that LTα1β2 and TNF are required for the development and function of B and T zone stromal cells that make chemokines necessary for lymphocyte compartmentalization in the spleen.
Practical Modeling Concepts for Connective Tissue Stem Cell and Progenitor Compartment Kinetics

Stem cell activation and development is central to skeletal development, maintenance, and repair, as it is for all tissues. However, an integrated model of stem cell proliferation, differentiation, and transit between functional compartments has yet to evolve. In this paper, the authors review current concepts in stem cell biology and progenitor cell growth and differentiation kinetics in the context of bone formation. A cell-based modeling strategy is developed and offered as a tool for conceptual and quantitative exploration of the key kinetic variables and possible organizational hierarchies in bone tissue development and remodeling, as well as in tissue engineering strategies for bone repair.
Torque ripple attenuation in permanent magnet synchronous motors

The authors study the torque ripple attenuation of permanent magnet synchronous motors caused by EMF harmonics and cogging torque. First, the magnet arc influence upon these variables is analyzed. Next, the impact on the harmonic contents caused by attenuation methods such as stator slot skewing, permanent magnet shifting and combinations of the two are presented. The last method makes it possible, using results of the simplest case (nonskewed slots and aligned magnets), to obtain the waveform of the EMF and cogging torque in more complex cases. The best combinations of the magnet arc and harmonic attenuation methods for minimizing electric torque harmonics and cogging torque are suggested. An analysis of cogging torque sensitivity to errors in the slot skewing angle is discussed. <<ETX>>