Miracle-dz/UniFAR-FTUs huggingface dataset:
Progressive Bidirectional Feature Extraction and Enhancement Network for Quality Evaluation of Night-Time Images

Blind image quality assessment (BIQA) has received increasing attention in the past decades. However, it still remains inadequately researched on BIQA for night-time images suffering from the diverse authentic degradations. Since the intrinsic content degradations of night-time images are highly related to the illumination, how to use the connection between content and illumination to enhance the feature representation ability is the key issue in designing BIQA methods for night-time images. In this article, we first construct an ultra-high-definition night-time image dataset (UHD-NID) with high image resolution and abundant parameter settings. UHD-NID contains 1600 images with a high resolution of 5616 × 3744, and each group of images contains ten exposure levels. Then, we conduct subjective assessment and analyze the subjective data to obtain a mean opinion score to each image in UHD-NID. To enhance the feature representation ability in content and illumination, we propose a Progressive Bidirectional Feature Extraction and Enhancement Network (PBFEE-Net). In addition, we use a decomposition network to decompose the input image into the reflectance and illumination, which can facilitate the ability of feature extraction to some extent. The experimental results show that our proposed method achieves superior performance in evaluating the quality of night-time images.
An Improved Edge Detection Algorithm of SAR Images

Ratio edge detector for SAR images can provide high overall edge\|detection probability. But it has defects on the accuracy of edge\|position determination. This paper works deeply on how to determinate the threshold of Ratio edge detector. Then we present a new detector aiming at detecting “weak” edges with threshold of it. A new combined algorithm including both of the two detectors is presented. Its processing results of actual SAR images show wonderful edge\|detection performance and high accuracy of edge\|position determination.
Expanded directly binds conserved regions of Fat to restrain growth via the Hippo pathway

The Hippo pathway is a conserved and critical regulator of tissue growth. The FERM protein Expanded is a key signalling hub that promotes activation of the pathway, stimulating inhibition of the transcriptional co-activator Yorkie. Previous work defined the transmembrane polarity determinant Crumbs as the primary regulator of Expanded. Here we show that the giant atypical cadherin Fat is essential in regulating Expanded function independently of Crumbs. We show that direct interaction between a highly conserved region of the Fat intracellular domain and Expanded recruits Expanded to the plasma membrane. In vivo deletion of Expanded binding regions in Fat causes loss of apical Expanded and promotes tissue overgrowth. In addition, we find that Dachsous binds Fat via interactions of their cytoplasmic domains, and that Expanded can be stabilised by Fat independently of Dachsous binding. These data provide new mechanistic insights into how Fat regulates Expanded, and how Hippo signalling is regulated during organ growth.
Hydrogen-Rich Saline—A Novel Neuroprotective Agent in a Mouse Model of Experimental Cerebral Ischemia via the ROS-NLRP3 Inflammasome Signaling Pathway In Vivo and In Vitro

Background: Our previous research revealed that inflammation plays an important role in the pathophysiology of cerebral ischemia. The function of the NOD-like receptor protein 3 (NLRP3) inflammasome is to activate the inflammatory process. Recent findings suggest that reactive oxygen species (ROS) are essential secondary messengers that activate the NLRP3 inflammasome. Hydrogen-rich saline (HS) has attracted attention for its anti-inflammatory properties. However, the protective effect and possible mechanism of HSin brain ischemia have not been well elucidated. Methods: To test the therapeutic effect of HS, we established a mouse model of distal middle cerebral artery occlusion (dMCAO) and an in vitro model of BV2 cells induced by lipopolysaccharide (LPS). The ROS scavenger N-acetylcysteine (NAC) was used to investigate the underlying mechanisms of HS. Results: HS significantly improved neurological function, reduced infarct volume, and increased cerebral blood flow in a dMCAO mouse model. ROS, NLRP3, Caspase-1, and IL-1β expression increased after cerebral ischemia, and this was reversed by HS treatment. In BV2 cells, the application of NAC further demonstrated that HS could effectively inhibit the expression of the ROS-activated NLRP3 inflammasome. Conclusions: HS, as a novel therapeutic option, could exert protect the brain by inhibiting the activation of the ROS-NLRP3 signaling pathway after cerebral ischemia.
Real-Time Search-Assisted Multiplexed Quantitative Proteomics Reveals System-Wide Translational Regulation of Non-Canonical Short Open Reading Frames

Abnormal expression of histone deacetylases (HDACs) is reported to be associated with angiogenesis, metastasis and chemotherapy resistance regarding cancer in a wide range of previous studies. Suberoylanilide hydroxamic acid (SAHA) is well known to function as a pan-inhibitor for HDACs and recognized as one of the therapeutic drug candidates to epigenetically coordinate cancer cell fate regulation on a genomic scale. Here, we established a Real-Time Search (RTS)-assisted mass spectrometric platform for system-wide quantification of translated products encoded by non-canonical short open reading frames (ORFs) as well as already annotated protein coding sequences (CDSs) on the human transciptome and applied this methodology to quantitative proteomic analyses of suberoylanilide hydroxamic acid (SAHA)-treated human HeLa cells to evaluate proteome-wide regulation in response to drug perturbation. Very intriguingly, our RTS-based in-depth proteomic analysis enabled us to identify approximately 5000 novel peptides from the ribosome profiling-based short ORFs encoded in the diversified regions on presumed ‘non-coding’ nucleotide sequences of mRNAs as well as lncRNAs and nonsense mediated decay (NMD) transcripts. Furthermore, TMT-based multiplex large-scale quantification of the whole proteome changes upon differential SAHA treatment unveiled dose-dependent selective translational regulation of a limited fraction of the non-canonical short ORFs in addition to key cell cycle/proliferation-related molecules such as UBE2C, CENPF and PRC1. Our study provided the first system-wide landscape of drug-perturbed translational modulation on both canonical and non-canonical proteome dynamics in human cancer cells.
How Mass Media Brings about Changes of Social Behavior in Developing Countries: A Case Study of the Radio Program Bhanchhin Aama in Nepal

This article presents a case study that explores how mass media induces changes in social behavior in developing countries. The radio program, Bhanchhin Aama (“Mother Knows Best”) is a communication strategy applied within the the United States Agency for International Development-funded Suaahara (“Good Nutrition”) Project in Nepal. This project deploys an entertainment–education strategy and interpersonal communication to generate community-based discussions and foster society-wide changes in social behavior. The study data were compiled from relevant documents posted on official websites and from in-depth interviews conducted with program staff and audiences. The analysis revealed that the radio program’s communication strategy has significantly contributed to transforming the development communication paradigm from being top-down to becoming bottom-up, which is more effective for inducing social behavioral changes.
Contrasting structures between the decoupled and coupled states of the stable boundary layer

Different aspects of the stable boundary‐layer structure are contrasted between the very stable and the weakly stable regimes from a new point of view. This study finds a limit wind speed, referred to as the crossover threshold, when the average vertical gradient of the turbulent kinetic energy switches sign at all observational levels. When the wind speed exceeds this transition, the entire stable boundary layer becomes vertically fully coupled. Consequently the very stable boundary layer in this study is considered as a decoupled regime, while the weakly stable state is referred to as a coupled regime. It is shown that the vertical profiles of other quantities, such as friction velocity, heat flux and thermal gradients are strikingly different between the two coupling states.
Study of fluorine-doped tin oxide thin films deposited by pneumatic spray pyrolysis and ultrasonic spray pyrolysis: a direct comparison

A comparative analysis was performed of fluorine-doped tin oxide (FTO) thin films deposited through two different systems: pneumatic spray pyrolysis and ultrasonic spray pyrolysis. The films were deposited on glass substrates at 460 °C, with varying weight ratios of fluorine to tin (F/Sn = 0.35, F/Sn = 0.50, and F/Sn = 0.65). The investigation focuses on the evolution of the film’s crystallinity, structural, morphological, transmittance, optical, and electrical properties. Resonant nuclear reaction (RNR) and energy dispersive spectroscopy (EDS) techniques were used to confirm the presence of fluorine in the FTO samples. The results show that the sample with F/Sn = 0.50 deposited through pneumatic spray pyrolysis, with a figure of merit of 34.5 × 10−3 Ω−1, exhibits the best characteristics for use as electrodes in optoelectronic devices, particularly in the fabrication of solar cells.
Quantum theory from one global symmetry

It is shown that unitary quantum theory is not only consistent with but follows from decompositional equivalence: the principle that there is no preferred decomposition of the universe into systems, or alternatively, that there is no preferred quantum reference frame. Decompositional equivalence requires unitary quantum theory to be both observerand scale-independent, requires time, “systems” and all classical information to be strictly observer-relative, and imposes an unavoidable free-energy cost on the acquisition of observational outcomes. This free energy cost of observation is characterized from first principles and shown to accord with known costs of information acquisition and storage by human observers.
Migraine and risk of premature myocardial infarction and stroke among men and women: A Danish population-based cohort study

Background Migraine carries risk of myocardial infarction (MI) and stroke. The risk of premature MI (i.e., among young adults) and stroke differs between men and women; previous studies indicate that migraine is mainly associated with an increased risk of stroke among young women. The aim of this study was to examine impact of migraine on the risk of premature (age ≤60 years) MI and ischemic/hemorrhagic stroke among men and women. Methods and findings Using Danish medical registries, we conducted a nationwide population-based cohort study (1996 to 2018). Redeemed prescriptions for migraine-specific medication were used to identify women with migraine (n = 179,680) and men with migraine (n = 40,757). These individuals were matched on sex, index year, and birth year 1:5 with a random sample of the general population who did not use migraine-specific medication. All individuals were required to be between 18 and 60 years old. Median age was 41.5 years for women and 40.3 years for men. The main outcome measures to assess impact of migraine were absolute risk differences (RDs) and hazard ratios (HRs) with 95% confidence intervals (CIs) of premature MI, ischemic, and hemorrhagic stroke, comparing individuals with migraine to migraine-free individuals of the same sex. HRs were adjusted for age, index year, and comorbidities. The RD of premature MI for those with migraine versus no migraine was 0.3% (95% CI [0.2%, 0.4%]; p < 0.001) for women and 0.3% (95% CI [−0.1%, 0.6%]; p = 0.061) for men. The adjusted HR was 1.22 (95% CI [1.14, 1.31]; p < 0.001) for women and 1.07 (95% CI [0.97, 1.17]; p = 0.164) for men. The RD of premature ischemic stroke for migraine versus no migraine was 0.3% (95% CI [0.2%, 0.4%]; p < 0.001) for women and 0.5% (95% CI [0.1%, 0.8%]; p < 0.001) for men. The adjusted HR was 1.21 (95% CI [1.13, 1.30]; p < 0.001) for women and 1.23 (95% CI [1.10, 1.38]; p < 0.001) for men. The RD of premature hemorrhagic stroke for migraine versus no migraine was 0.1% (95% CI [0.0%, 0.2%]; p = 0.011) for women and −0.1% (95% CI [−0.3%, 0.0%]; p = 0.176) for men. The adjusted HR was 1.13 (95% CI [1.02, 1.24]; p = 0.014) for women and 0.85 (95% CI [0.69, 1.05]; p = 0.131) for men. The main limitation of this study was the risk of misclassification of migraine, which could lead to underestimation of the impact of migraine on each outcome. Conclusions In this study, we observed that migraine was associated with similarly increased risk of premature ischemic stroke among men and women. For premature MI and hemorrhagic stroke, there may be an increased risk associated with migraine only among women.
Late gestational nutrient restriction in primiparous beef females: nutrient partitioning among the dam, fetus, and colostrum during gestation

Abstract Fall-calving primiparous crossbred beef females [body weight (BW): 451 ± 28 (SD) kg; body condition score (BCS): 5.4 ± 0.7] were allocated by fetal sex and expected calving date to receive either 100% (control; CON; n = 13) or 70% (nutrient restricted; NR; n = 13) of metabolizable energy and metabolizable protein requirements for maintenance, pregnancy, and growth from day 160 of gestation to calving. Heifers were individually-fed chopped poor quality hay and supplemented to meet targeted nutritional planes based on estimated hay intakes. Dam BW, BCS, backfat, and metabolic status were determined pre-treatment, every 21 d (BW and metabolic status) or 42 d (BCS and backfat) during gestation, and post-calving. At birth, calf BW and size were measured, and total colostrum from the most full rear quarter was collected pre-suckling. Data were analyzed with nutritional plane, treatment initiation date, and calf sex (when P < 0.25) as fixed effects. Gestational metabolites included day and nutritional plane × day as repeated measures. During late gestation, CON dams gained (P < 0.01) maternal (non-gravid) BW and maintained (P ≥ 0.17) BCS and backfat, while NR dams lost (P < 0.01) maternal BW, BCS, and backfat. Circulating glucose, urea N, and triglycerides were less (P ≤ 0.05) in NR dams than CON at most late gestational timepoints after treatment initiation. Circulating non-esterified fatty acids were greater (P < 0.01) in NR dams than CON. Post-calving, NR dams weighed 63.6 kg less (P < 0.01) and were 2.0 BCS less (P < 0.01) than CON. At 1 h post-calving, NR dams had less (P = 0.01) plasma glucose and tended to have less (P = 0.08) plasma triglycerides than CON. Nutrient restriction did not affect (P ≥ 0.27) gestation length, calf birth weight, or calf size at birth. Colostrum yield was 40% less (P = 0.04) in NR dams than CON. Protein and immunoglobulin concentrations were greater (P ≤ 0.04), but free glucose and urea N concentrations were less (P ≤ 0.03), in colostrum of NR dams than CON. Colostrum total lactose, free glucose, and urea N were less (P ≤ 0.03) in NR dams than CON, but total protein, triglycerides, and immunoglobulins were not affected (P ≥ 0.55). In summary, beef heifers experiencing late gestational nutrient restriction prioritized partitioning nutrients to fetal growth and colostrum production over maternal growth. During undernutrition, fetal and colostral nutrient demands were largely compensated for by catabolism of maternal tissue stores.
The viability of a proposed psychoeducational neurodiversity approach in children services: The PANDA (the Portsmouth alliance’s neuro-diversity approach)

People with Neurodevelopmental (ND) conditions are often unfairly stereotyped by society, without fully appreciating their strengths. As a result, their advantageous behaviours may be overlooked or ignored. Despite wide psychoeducation on ND in society there is a push from the scientific and ND community to move from a binary diagnostic system to an approach that encompasses the spectrum experienced by individuals. In view of this, we have developed the Portsmouth Alliance Neuro-Diversity Approach (PANDA), a coproduced method which helps facilitate understanding, communication and early support for individuals who may be Neuro-Diverse. 51 young people, their parents and attached professionals participated in the approach’s feasibility to improve wellbeing and symptom management measured by quantitative and qualitative means. Results showed a significant improvement in the child’s wellbeing, but not symptom management. Overall, this indicates the PANDA could facilitate a more holistic approach for referrals, information gathering, psychoeducation and cross-system relationship building to be used in conjunction with a traditional pathway. Though, this study is limited in scope, its main purpose is to inform future development of the approach. Additionally, more research investigating the specific narrative, and separate structure of the PANDA would be required to highlight the strengths and limitations of implementation.
Cannulation Skill Assessment Using Functional Data Analysis

Objective: A clinician's operative skill—the ability to safely and effectively perform a procedure—directly impacts patient outcomes and well-being. Therefore, it is necessary to accurately assess skill progression during medical training as well as develop methods to most efficiently train healthcare professionals. Methods: In this study, we explore whether time-series needle angle data recorded during cannulation on a simulator can be analyzed using functional data analysis methods to (1) identify skilled versus unskilled performance and (2) relate angle profiles to degree of success of the procedure. Results: Our methods successfully differentiated between types of needle angle profiles. In addition, the identified profile types were associated with degrees of skilled and unskilled behavior of subjects. Furthermore, the types of variability in the dataset were analyzed, providing particular insight into the overall range of needle angles used as well as the rate of change of angle as cannulation progressed in time. Finally, cannulation angle profiles also demonstrated an observable correlation with degree of cannulation success, a metric that is closely related to clinical outcome. Conclusion: In summary, the methods presented here enable rich assessment of clinical skill since the functional (i.e., dynamic) nature of the data is duly considered.
Alterations in Achilles tendon stress and strain across a range of running velocities

ABSTRACT Running has a high incidence of overuse injuries. Achilles tendon (AT) injuries may occur due to high forces and repetitive loading during running. Foot strike pattern and cadence have been linked to the magnitude of AT loading. The effect of running speed on AT stress and strain, muscle forces, gait parameters and running kinematics is not well addressed in recreational runners with lower pace of running. Twenty-two female participants ran on an instrumented treadmill between 2.0 and 5.0 m/s. Kinetic and kinematic data were obtained. AT cross-sectional area data were collected using ultrasound imaging. Inverse dynamics with static optimization was used to calculate muscle forces and AT loading. AT stress, strain and cadence increased with greater running speed. Foot inclination angle indicated a rearfoot strike pattern among all participants, which increased as running speed increased but the latter plateaued after 4.0 m/s. The soleus contributed more force in running compared to the gastrocnemius throughout all speeds. Highest running speeds had the most stress on the AT, with changes to foot inclination angle and cadence. Understanding the relation of AT loading variables with running speed may aid in understanding how applied load may influence injury.
In Vitro and In Vivo Biological Activities of Dipicolinate Oxovanadium(IV) Complexes

The work is focused on anticancer properties of dipicolinate (dipic)-based vanadium(IV) complexes [VO(dipic)(N∩N)] bearing different diimines (2-(1H-imidazol-2-yl)pyridine, 2-(2-pyridyl)benzimidazole, 1,10-phenanthroline-5,6-dione, 1,10-phenanthroline, and 2,2′-bipyridine), as well as differently 4,7-substituted 1,10-phenanthrolines. The antiproliferative effect of V(IV) systems was analyzed in different tumors (A2780, HCT116, and HCT116-DoxR) and normal (primary human dermal fibroblasts) cell lines, revealing a high cytotoxic effect of [VO(dipic)(N∩N)] with 4,7-dimethoxy-phen (5), 4,7-diphenyl-phen (6), and 1,10-phenanthroline (8) against HCT116-DoxR cells. The cytotoxicity differences between these complexes can be correlated with their different internalization by HCT116-DoxR cells. Worthy of note, these three complexes were found to (i) induce cell death through apoptosis and autophagy pathways, namely, through ROS production; (ii) not to be cytostatic; (iii) to interact with the BSA protein; (iv) do not promote tumor cell migration or a pro-angiogenic capability; (v) show a slight in vivo anti-angiogenic capability, and (vi) do not show in vivo toxicity in a chicken embryo.
Bradykinin release following trauma and hemorrhagic shock causes pulmonary alveolar leak in a rodent model

Severe injury activates the coagulation cascade which releases bradykinin (BK). BK causes vascular leak into the tissues. In an animal model of trauma lung leak occurred which was inhibited by a specific BK receptor antagonist. BK inhibition may decrease postinjury ARDS. BACKGROUND Hemorrhage accounts for 40% of the preventable death following severe injury. Activation of systemic coagulation produces bradykinin (BK), which may cause leak from the plasma to the extravascular space and to the tissues, which is part of the complex pathophysiology of trauma-induced end-organ injury. We hypothesize that BK, released during activation of coagulation in severe injury, induces pulmonary alveolar leak. METHODS Isolated neutrophils (PMNs) were pretreated with a specific BK receptor B2 antagonist HOE-140/icatibant and BK priming of the PMN oxidase was completed. Rats underwent tissue injury/hemorrhagic shock (TI/HS), TI/icatibant/HS, and controls (no injury). Evans blue dye was instilled, and the percentage leak from the plasma to the lung was calculated from the bronchoalveolar lavage fluid (BALF). CINC-1 and total protein were measured in the BALF, and myeloperoxidase was quantified in lung tissue. RESULTS The BK receptor B2 antagonist HOE140/icatibant inhibited (85.0 ± 5.3%) BK priming of the PMN oxidase (p < 0.05). The TI/HS model caused activation of coagulation by increasing plasma thrombin-antithrombin complexes (p < 0.05). Versus controls, the TI/HS rats had significant pulmonary alveolar leak: 1.46 ± 0.21% versus 0.36 ± 0.10% (p = 0.001) and increased total protein and CINC-1 in the BALF (p < 0.05). Icatibant given after the TI significantly inhibited lung leak and the increase in CINC-1 in the BALF from TI/icatibant/HS rats versus TI/HS (p < 0.002 and p < 0.05) but not the total protein. There was no PMN sequestration in the lungs. Conclusions: This mixed injury model caused systemic activation of hemostasis and pulmonary alveolar leak likely due to BK release. CONCLUSION This mixed injury model caused systemic activation of hemostasis and pulmonary alveolar leak likely due to BK release. LEVEL OF EVIDENCE Original Article, Basic Science