Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis and Identification of Genes Associated with the Desiccation Sensitivity of Panax notoginseng Seeds

Panax notoginseng (Burk.) F. H. Chen, a species of the genus Panax, radix has been traditionally used to deal with various hematological diseases and cardiovascular diseases since ancient times in East Asia. P. notoginseng produces recalcitrant seeds which are sensitive to desiccation and difficult to store for a long time. However, few data are available on the mechanism of the desiccation sensitivity of P. notoginseng seeds. To gain a comprehensive perspective of the genes associated with desiccation sensitivity, cDNA libraries from seeds under control and desiccation processes were prepared independently for Illumina sequencing. The data generated a total of 70,189,896 reads that were integrated and assembled into 55,097 unigenes with a mean length of 783 bp. In total, 12,025 differentially expressed genes (DEGs) were identified during the desiccation process. Among these DEGs, a number of central metabolism, hormonal network-, fatty acid-, and ascorbate-glutathione-related genes were included. Our data provide a comprehensive resource for identifying the genes associated with the desiccation sensitivity of P. notoginseng seeds.
Psychometric evaluation and reference values for the German Postconcussion Symptom Inventory (PCSI-SR8) in children aged 8–12 years

Background Post-concussion symptoms (PCS) are a common consequence of pediatric traumatic brain injury (pTBI). They include cognitive, emotional, and physical disturbances. To address the lack of age-adapted instruments assessing PCS after pTBI, this study examines the psychometric properties of the German 17-item post-TBI version of the Postconcussion Symptom Inventory (PCSI-SR8) in children aged 8–12 years. The study also aims to establish reference values based on data from a pediatric general population sample to better estimate the prevalence and clinical relevance of PCS after pTBI in clinical and research settings. Methods A total of 132 children aged 8–12 years from a post-acute TBI sample and 1,047 from a general population sample were included in the analyses. The questionnaire was translated from English into German and linguistically validated using forward and backward translation and cognitive debriefing to ensure comprehensibility of the developed version. Reliability and validity were examined; descriptive comparisons were made with the results of the English study. Measurement invariance (MI) analyses between TBI and general population samples were conducted prior to establishing reference values. Factors contributing to the total and scale scores of the PCSI-SR8 were identified using regression analyses. Reference values were calculated using percentiles. Results Most children (TBI: 83%; general population: 79%) rated at least one symptom as “a little” bothersome. The German PCSI-SR8 met the psychometric assumptions in both samples and was comparable to the English version. The four-factor structure comprising physical, emotional, cognitive, and fatigue symptoms could be replicated. The MI assumption was retained. Therefore, reference values could be provided to determine the symptom burden of patients in relation to a comparable general population. Clinical relevance of reported symptoms is indicated by a score of 8, which is one standard deviation above the mean of the general population sample. Conclusion The German version of the PCSI-SR8 is suitable for assessment of PCS after pTBI. The reference values allow for a more comprehensive evaluation of PCS following pTBI. Future research should focus on validation of the PCSI-SR8 in more acute phases of TBI, psychometric examination of the pre-post version, and child-proxy comparisons.
Financial literacy and its impact on the credit card debt puzzle

The credit card debt puzzle is not well understood. Households exhibit inefficient behavior when they have sufficient liquid assets to pay off their credit card balance, but do not. Based multinomial regression analyses of the 2016 Survey of Consumer Finances, the study discovered that households that display this behavior are more likely to have lower financial literacy than convenience users. The findings suggest financially literate households are less likely to display irrational behavior regarding the credit card debt puzzle.
Gas Chromatography–Mass Spectrometry Detection of Thymoquinone in Oil and Serum for Clinical Pharmacokinetic Studies

Thymoquinone (TQ) is the primary component of Nigella sativa L. (NS) oil, which is renowned for its potent hepatoprotective effects attributed to its antioxidant, anti-fibrotic, anti-inflammatory, anti-carcinogenic, and both anti- and pro-apoptotic properties. The aim of this work was to establish a method of measuring TQ in serum in order to investigate the pharmacokinetics of TQ prior to a targeted therapeutic application. In the first step, a gas chromatography–mass spectrometry method for the detection and quantification of TQ in an oily matrix was established and validated according to European Medicines Agency (EMA) criteria. For the assessment of the clinical application, TQ concentrations in 19 oil preparations were determined. Second, two serum samples were spiked with TQ to determine the TQ concentration after deproteinization using toluene. Third, one healthy volunteer ingested 1 g and another one 3 g of a highly concentrated NS oil 30 and 60 min prior to blood sampling for the determination of serum TQ level. After the successful establishment and validation of the measurement method, the highest concentration of TQ (36.56 g/L) was found for a bottled NS oil product (No. 1). Since a capsule is more suitable for oral administration, the product with the third highest TQ concentration (No. 3: 24.39 g/L) was used for all further tests. In the serum samples spiked with TQ, the TQ concentration was reliably detectable in a range between 5 and 10 µg/mL. After oral intake of NS oil (No. 3), however, TQ and/or its derivatives were not detectable in human serum. This discrepancy in detecting TQ after spiking serum or following oral ingestion may be attributed to the instability of TQ in biomatrices as well as its strong protein binding properties. A pharmacokinetics study was therefore not viable. Studies on isotopically labeled TQ in an animal model are necessary to study the pharmacokinetics of TQ using alternative modalities.
Hydrological modelling of an agricultural watershed in India using the Soil and Water Assessment Tool

ii RÉSUMÉ . iii ACKNOWLEDGEMENTS . iv TABLE OF CONTENTS . v LIST OF TABLES . viii LIST OF FIGURES . x ABBREVIATIONS . 2 CHAPTER 1: INTRODUCTION . 4 1.1 Objectives . 7 1.2 Scope . 7 1.3 Thesis outline . 8 CHAPTER 2: LITERATURE REVIEW . 9 2.1 Water resources in India . 9 2.2 Water stress and productivity . 11 2.3 Climate variability and change . 13 2.3.1 Climate variability in the semi-arid tropics . 13 2.3.2 Climate change in South Asia . 14 2.3.3 Climate change and crop productivity . 16 2.4 Rainwater harvesting to cope with water scarcity . 17 2.5 Hydrological modelling . 18 2.5. 1 APSIM . 18 2.5. 2 SWAP . 18 2.5. 3 EPIC and APEX . 19 2.5. 4 SWAT . 19 2.6 SWAT modelling . 21 2.6. 1 Model selection . 21 2.6. 2 General SWAT hydrology . 21 2.6. 3 Runoff . 23 vi 2.6. 4 Crop sub-model and predicted yields . 25 2.6. 5 Climate change and weather generation . 27 2.6. 6 Soil and water conservation practices . 27 2.6. 7 Reservoirs . 29 2.7 Summary . 30 CHAPTER 3: METHODOLOGY.31 3.1 General description of the Padmalaya watershed . 31 3.2 Socio-economics of the study area . 33 3.3 Topography and hydrology . 35 3.4 Climate . 39 3.5 Soils . 42 3.6 Land use . 45 3.7 Soil and water management . 49 3.7. 1 In situ water conservation . 49 3.7. 2 Ex situ water harvesting . 51 3.8 Setup of the SWAT model . 51 3.8. 1 Parameterization . 51 3.8. 2 Calibration . 53 CHAPTER 4: SCENARIO DEVELOPMENT . 58 4.
Physical Activity, Body Composition, Serum Myokines and the Risk of Death in Hemodialysis Patients

Background and Objectives: The aim of this study was to assess the relationship between habitual physical activity, body composition, serum myokine concentration, and all-cause mortality in chronic hemodialysis patients. Materials and Methods: A prospective cohort study with a 7-year follow-up was conducted in a group of 38 patients (24 men, 14 women, mean age 65.6 ± 13.9 years, dialysis vintage 1.17 ± 1.25 years). Baseline serum concentrations of myokines—follistatin and myostatin—were assessed along with a measurement of physical activity with multidimensional accelerometery, body composition, and the force of forearm muscle contraction. Survival analysis was performed using the Kaplan–Meier method for tertiles of follistatin, serum myostatin, body composition, and physical activity expressed in metabolic equivalents (MET). Results: The mean physical activity among patients was 81 min/24 h (median 38.5 min), and the mean weekly 3MET activity was 493 min (median 218 min). The probability of survival of patients was significantly lower in the subgroup with 3MET/24 h less than 26 min/24 h and 3METt less than 148 min per week compared to the other subgroup (p = 0.006 and p = 0.006, respectively). During the 70-month follow-up, the subgroup with the lowest baseline follistatin concentration showed a significantly lower risk of death (p = 0.02). Baseline myostatin levels were not significant risk factors for mortality, nor were BMI or lean and fat tissue index categories. Conclusions: Physical activity and low plasma follistatin, but not body composition indexes or plasma myostatin, could serve as predictors of all-cause mortality in hemodialysis patients.
Recent Advances in Flexible Multifunctional Sensors

Wearable electronics have received extensive attention in human–machine interactions, robotics, and health monitoring. The use of multifunctional sensors that are capable of measuring a variety of mechanical or environmental stimuli can provide new functionalities for wearable electronics. Advancements in material science and system integration technologies have contributed to the development of high-performance flexible multifunctional sensors. This review presents the main approaches, based on functional materials and device structures, to improve sensing parameters, including linearity, detection range, and sensitivity to various stimuli. The details of electrical, biocompatible, and mechanical properties of self-powered sensors and wearable wireless systems are systematically elaborated. Finally, the current challenges and future developmental directions are discussed to offer a guide to fabricate advanced multifunctional sensors.
A Quantitative Framework to Derive Robust Characterization of Hydrological Gradients

If ecological management of river ecosystems is to keep pace with increasing pressure to abstract, divert and dam, we must develop general flow–ecology relationships to predict the impacts of these hydrologic alterations. Regional flow gradient analyses are a promising tool to quickly reveal these functional relationships, but there are considerable uncertainties in this method because of variability in the historical extent of flow data across different rivers, combined with multiple indices characterizing the ecological attributes of flow regimes. In response, we outline an objective framework for analysing spatial hydrologic gradients that addresses three major sources of uncertainty: robust estimation of flow indices, the potential for temporal trends to confound spatial variation in flow regimes and the statistical robustness to detect underlying hydrological gradients. The utility of our framework was examined in relation to flow regimes across multiple braided river catchments in Canterbury, New Zealand. We found that a subset of flow indices could be robustly estimated using only 10 years of flow data, although indices that captured flow ‘timing’ required longer time series. Temporal trends were unlikely to confound conclusions from a spatial hydrologic gradient analysis, and there were three statistically supported hydrologic gradients related to flow magnitude, flow variability and low flow events. The widespread application of robust spatial flow gradient analyses has the potential to further our understanding of how altered flow regimes affect the ecology of freshwater and riparian ecosystems, thereby providing the evidence base to inform river management. Copyright © 2016 John Wiley & Sons, Ltd.
One Step Closer to Enigmatic USCα Methanotrophs: Isolation of a Methylocapsa-like Bacterium from a Subarctic Soil

The scavenging of atmospheric trace gases has been recognized as one of the lifestyle-defining capabilities of microorganisms in terrestrial polar ecosystems. Several metagenome-assembled genomes of as-yet-uncultivated methanotrophic bacteria, which consume atmospheric CH4 in these ecosystems, have been retrieved in cultivation-independent studies. In this study, we isolated and characterized a representative of these methanotrophs, strain D3K7, from a subarctic soil of northern Russia. Strain D3K7 grows on methane and methanol in a wide range of temperatures, between 5 and 30 °C. Weak growth was also observed on acetate. The presence of acetate in the culture medium stimulated growth at low CH4 concentrations (~100 p.p.m.v.). The finished genome sequence of strain D3K7 is 4.15 Mb in size and contains about 3700 protein-encoding genes. According to the result of phylogenomic analysis, this bacterium forms a common clade with metagenome-assembled genomes obtained from the active layer of a permafrost thaw gradient in Stordalen Mire, Abisco, Sweden, and the mineral cryosol at Axel Heiberg Island in the Canadian High Arctic. This clade occupies a phylogenetic position in between characterized Methylocapsa methanotrophs and representatives of the as-yet-uncultivated upland soil cluster alpha (USCα). As shown by the global distribution analysis, D3K7-like methanotrophs are not restricted to polar habitats but inhabit peatlands and soils of various climatic zones.
Urinary extracellular vesicle dynamics in Parkinson's disease patients with urinary dysfunction

Parkinson's disease (PD) presents with severe motor manifestations and a plethora of non-motor symptoms. Urinary dysfunctions are one of the most common non-motor symptoms of PD patients responsible for reduced quality of life. Urinary extracellular vesicles (EVs) are mostly considered to originate from the cells in the urogenital tract. In this study, we have performed urinary EV analysis in 29 PD cases with varied severity of urinary dysfunction and correlated it with the EV dynamics in 29 age-matched controls. In the studied cases, apart from urinary dysfunction, symptoms of depression, anxiety, cognitive dysfunction, sleep, and wakefulness were observed in >75% of the cases. No significant difference in urinary EV size, concentration and urinary EV protein concentration was observed between PD cases with urinary dysfunction and controls. However, a significant positive association was observed between urinary EV concentration and motor scores (p = 0.042), while no association was observed between urinary EV concentration and urinary dysfunction scores. Chronic stress induced by motor symptoms could be one of the reasons for excessive EV production in PD patients with urinary dysfunctions. Large-scale studies on the association of urinary EV dynamics with motor and non-motor symptoms may provide additional information on urinary dysfunction in PD.
The impact of competitive youth athlete injury on parents: a narrative review

Athletic injuries are common in youth sports, and much research has focused on the injury experience of athletes. However, less attention has been given to the impact of adolescent injury on relevant others within athletes’ recovery orbit, particularly parents. This narrative review examines the impact of adolescent injury on parents using the Multilevel Model of Sport Injury (MMSI). Results revealed that parents’ experience of their adolescent’s injury is influenced by intra-and inter-personal factors (e.g., thoughts, emotions, behaviors, and interactions with coaches, and sport medicine providers), as well as institutional, cultural, and policylevel factors (e.g., lack of organizational support, internalization of sport norms about playing with pain, and sport injury policies and guidelines). The review provides a more nuanced understanding of the factors and interactions that parents have following adolescent sport injury. Further research using the MMSI can extend current conceptualization and theorizing regarding parents’ experiences following adolescent injury.
The Relationship Between Stress Level and Sleep Paralysis During COVID-19 among Final-Year Nursing Students

World Health Organization warns that stress will increase due to the COVID-19 pandemic situation. Stress can disrupt sleep quality, and the potential for experiencing sleep paralysis is most common in students, which can reduce students' academic abilities. This study aimed to identify the correlation between stress levels and sleep paralysis in final-year nursing students during COVID-19. ; The research design describes the correlation with a Cross-Sectional approach with a total sampling technique of 238 final-year nursing students. Data were analyzed using a chi-square test; Results: with Asymp.Sig 0.012˂0.05, there is a correlation between stress levels and sleep paralysis. More than half of 152 students (63.9%) with moderate stress levels experienced sleep paralysis, a small portion of 41 (17.2%) students with severe stress levels experienced sleep paralysis and students with mild stress levels 15 (6.3%) experienced sleep paralysis; Conclusions: in this study indicate that the highest stress level experiences sleep paralysis at moderate stress levels. Students are expected to further optimize the counseling activities held by the institution, and the institution can provide interventions such as progressive muscle relaxation therapy to reduce stress levels and sleep disturbances.
Impermeability Evaluation Of Concrete With Fly Ash Aggregate And Prediction With Modelling

Concrete is the most synthesized material in construction sector which it has aggregate as one of its components. The use of natural aggregate in concrete preparation uses a significant amount of non-renewable resources and energy, having a significant environmental impact. Multiple research projects have been conducted to safeguard natural reserves, seeking a solution to the waste disposal issue, and reduce construction costs by utilizing waste materials. FA(Fly Ash) aggregate is one such material that can be a replacement for natural aggregate. Durability parameters of concrete with Fly Ash (FA) aggregate are studied in this work as an alternative for fine aggregate. In this study, 5 concrete mixes were prepared utilizing FA aggregate in percentage substitution of 0%, 10%, 20%, 30%, and 40% for each. The quantity of cement, compaction, curing rate, concrete cover, and porosity all influence the durability of the concrete. Concrete attributes such as strength in compression, retaliation to abrasion and half-cell potential were investigated. Durability parameters of the specimens were tested after 90-day curing. The results revealed that concrete with 30% FA aggregate had the highest compressive strength, improved resistance towards abrasion and least half cell potential values. Experimentation data were used to develop comprehensive prediction models by applying support vector machine (SVM) algorithm. The SVM model analyses R2 values with an accuracy of over 97%. As a result, we can use SVM to efficiently execute prediction modelling in construction area.
The CHANGED Score—A New Tool for the Prediction of Insulin Dependency in Gestational Diabetes

Gestational diabetes (GDM) is a frequent complication during pregnancy. We aimed to develop a score to predict future insulin dependency in gestational diabetes (GDM). Data from 1611 patients from Charité Berlins gestational diabetes clinic from 2015 to 2022 were utilized. A stepwise backwards regression, including patient characteristics obtained at the initial presentation, was performed. Predictors examined included age, fasting blood glucose level, blood glucose levels one and two hours after oral glucose tolerance test, pre-pregnancy BMI, number of previous pregnancies and births, and fetal sex. The ideal cutoff value between high and low risk for insulin dependency was assessed and the score was internally validated. There were 1249 (77.5%) women diagnosed with dietary GDM and 362 (22.5%) were diagnosed with insulin-dependent GDM. The CHarité AssessmeNt of GEstational Diabetes (CHANGED) Score achieved an area under the curve of 0.77 (95% confidence interval 0.75–0.80; 0.75 in internal validation). The optimal cutoff value was calculated at a score value of 9 (72% sensitivity, 69% specificity). We developed an easily applicable tool to accurately predict insulin dependency in gestational diabetes. The CHANGED Score is routinely available and can potentially improve maternal and fetal outcomes.
Spatial analysis of data frequency and severity of rural accidents

In this paper, to study the frequency and severity of traffic accidents, a combination of geographic information system and spatial analysis has been used. For this purpose, methods of planar and network statistics including kernel density estimation and nearest neighbor distance analysis were applied for three types of accidents including fatal, injury, and material property damages. In addition, drawbacks of the traditional planar point pattern and the benefits of network analysis are offered. The network statistics are executed through SANET version 4 and ArcMap on the Semnan–Garmsar road in Iran. The nearest neighbor output analysis is consist of four curves, and regarding the fact that the amounts for accidents resulting in fatalities, injuries, and damages, the observed value curve is above the 5% confidence interval; accidents in the study region are more clustered than would be expected by random chance.
The Influence of Financial Knowledge, Financial Socialization on Financial Satisfaction with Financial Risk Attitude as a Mediation Variable in Millennial Generation in Padang City

This research has a purpose to analyze the influence of financial knowledge, financial socialization on financial satisfaction with financial risk attitude as a mediating variable in the millennial generation in Padang City. The population in this research is the millennial generation who already have income in the city of Padang. The total of samples in this research were 210 respondents. Data collection through distributing questionnaires online and processed data using SmartPLS software. The results of this research point that (1) financial knowledge has a significant effect on financial risk attitude , (2) financial socialization has no significant effect on financial risk attitude , (3) financial risk attitude has a significant effect on financial satisfaction , (4) financial knowledge has a significant effect on financial satisfaction , (5) financial socialization has a significant effect on financial satisfaction , (6) financial knowledge has no significant effect on financial satisfaction with financial risk attitude as mediation, (7) financial socialization has no significant effect on financial satisfaction with financial risk attitude as mediation.