Miracle-dz/UniFAR-FTUs huggingface dataset:
Pyrethroid resistance discovered in a major agricultural pest in southern Australia: the redlegged earth mite Halotydeus destructor (Acari: Penthaleidae).

BACKGROUND The redlegged earth mite (Halotydeus destructor Tucker) is an important pest of field crops and pastures. Control of this pest relies heavily on chemicals, with few genuine alternatives presently available. Pesticide responses of H. destructor from the field with reported chemical control failures were compared with mites from susceptible 'control' populations. Toxicology bioassays were conducted on adult mites across multiple generations. RESULTS Very high levels of resistance to two synthetic pyrethroids, bifenthrin and alpha-cypermethrin, were detected in this species for the first time. For bifenthrin, LC(50) estimates showed a difference in resistance of greater than 240 000-fold. Resistance to alpha-cypermethrin was almost 60 000-fold. This resistance was shown to be heritable, persisting after several generations of culturing. There was no evidence that resistance to organophosphorus chemicals had evolved, which is likely to be a direct consequence of the history of chemical applications these mites have experienced. CONCLUSION These results highlight the need for more judicious management decisions in order to control pest species in a sustainable manner. The implications of these findings in regard to the management and future research of the redlegged earth mite are discussed.
A Novel Symmetric Key Cryptography using Multiple Random Secret Keys

Cryptography is an essential practice required for secure communication between two parties. It preserves the confidentiality, integrity, availability, and authenticity of information thereby enhances the security of the data processing system and the information flow within an organization. Symmetric and asymmetric key cryptography are used for encryption and decryption of a message. Symmetric key cryptography is the most commonly used cryptography as it is fast and feasible for use in decrypting bulk messages and requires less computer resources. Chosenplaintext attacks have been proposed for symmetric key cryptography as it uses single secret key to encrypt different messages. This paper introduces a novel symmetric key cryptography, where multiple random secret keys can be used to encrypt different messages, which is insecure under cipher text-only attacks, a weaker form of attack than chosenplaintext attacks. General Terms Information Security, Cryptographic Algorithm.
Early knee osteoarthritis

Concepts regarding osteoarthritis, the most common joint disease, have dramatically changed in the past decade thanks to the development of new imaging techniques and the widespread use of arthroscopy that permits direct visualisation of intra-articular tissues and structure. MRI and ultrasound allow the early detection of pre-radiographic structural changes not only in the peri-articular bone but also in the cartilage, menisci, synovial membrane, ligaments and fat pad. The significance of MRI findings such as cartilage defects, bone marrow lesions, synovial inflammation/effusions and meniscal tears in patients without radiographic signs of osteoarthritis is not fully understood. Nevertheless, early joint tissue changes are associated with symptoms and, in some cases, with progression of disease. In this short review, we discuss the emerging concept of early osteoarthritis localised to the knee based on recently updated knowledge. We highlight the need for a new definition of early osteoarthritis that will permit the identification of patients at high risk of osteoarthritis progression and to initiate early treatment interventions.
Classical Kolmogorov scaling is inconsistent with local coupling

We consider cascade models of turbulence which are obtained by restricting the Navier-Stokes equation to local interactions. By combining the results of the method of extended self-similarity and a novel subgrid model, we investigate the inertial range fluctuations of the cascade. Significant corrections to the classical scaling exponents are found. The dynamics of our local Navier-Stokes models is described accurately by a simple set of Langevin equations proposed earlier as a model of turbulence [Phys. Rev. E {\bf 50}, 285 (1994)]. This allows for a prediction of the intermittency exponents without adjustable parameters. Excellent agreement with numerical simulations is found.
Federalismo fiscal en México

Este articulo describe la evolucion de las relaciones fiscales intergubernamentales de las ultimas dos decadas en Mexico. En el contexto de la literatura economica sobre federalismo fiscal, se sugiere que la evolucion reciente esta dando origen a un sistema distorsionado, donde las entidades federativas han estado recuperando capacidades de gasto, pero al mismo tiempo disponen de una muy reducida capacidad para obtener ingresos propios a traves de tributacion. Se sugiere, entonces, que los estados dispongan de mayores atribuciones impositivas, y a este respecto, es importante que una reforma fiscal haga planteamientos en esta direccion. Por ultimo, no esta claro cuanto se puede avanzar en el proceso de descentralizacion impositiva, sin poner en ‘peligro’ el gasto social del gobierno federal, que sin duda es importante en un pais tan heterogeneo como Mexico
Application of Minimal Perfect Hashing in Main Memory Indexing

With the rapid decrease in the cost of random access memory (RAM), it will soon become economically feasible to place full-text indexes of a library in main memory. One essential component of the indexing system is a hashing algorithm, which maps a keyword into the memory address of the index information corresponding to that keyword. This thesis studies the application of the minimal perfect hashing algorithm in main memory indexing. This algorithm is integrated into the index search engine of the Library 2000 system, a digital on-line library system. The performance of this algorithm is compared with that of the open-addressing hashing scheme. We find that although the minimal perfect hashing algorithm needs fewer keyword comparisons per keyword search on average, its hashing performance is slower than the open-addressing scheme. Thesis Supervisor: Jerome H. Saltzer Title: Professor, Department of Electrical Engineering and Computer Science
Small Solute Clearances and Clinical Outcomes in Capd

The strong correlation of weekly clearances of urea and creatinine with PCR suggests that minimum targets of 50 L/week/l. 73 m2 body surface area of creatinine clearance and a weekly kt/v urea of 1.7 are reasonable if protein intakes in excess of 0.8 g/kg normalized body weight are to be achieved in most CAPD patients. It would seem reasonable that this increases the chances for better nutrition. It would also seem reasonable that this should eventually improve long-term outcomes and survival in large population studies where the impact of dialysis dose could emerge as significant, even with the presence of all the other variables that are known to affect commonly monitored outcome parameters. These recommended targets are well below those achieved by hemodialysis; higher targets could possibly achieve even better long-term results, but this is unknown.
Glomerular cell crosstalk

Purpose of reviewGlomerular filtration occurs in specialized, microscopic organelles. Each glomerulus contains unique cells and these cooperate to maintain normal filtration. Phenomenal adaptation is required for the glomerulus to respond to variable mechanical loads and this adaptation requires efficient communication between the resident cells. This review will focus on the latest discoveries related to signalling events that mediate the crosstalk between glomerular cells, and detail how disease processes can influence normal regulation. Recent findingsNew data indicate that the crosstalk between glomerular cells involves an increasing number of secreted signalling ligands that act in an autocrine or paracrine fashion. Furthermore, extended roles for some of the classical signalling molecules have been described and there is emerging evidence of therapeutic strategies to manipulate cellular crosstalk. The glomerular extracellular matrix harbours many of these signalling ligands, acting as a reservoir and presenting ligands to cell surface receptors. Signals can also be transferred between cells by extracellular vesicles and this is an emerging concept in cellular crosstalk. SummaryRecent discoveries are building our understanding about glomerular cell crosstalk, and this review focuses on growth factors and signalling peptides, methods of delivery to target cells, and the potential for developing new therapies for glomerular disease.
Understanding Motor Development : Infants, Children, Adolescents, Adults

Unit 1 Background 1 Understanding Motor Development: An Overview 2 Models of Human Development 3 Motor Development: A Theoretical Model 4 Selected Factors Affecting Motor Development Unit 2 Infancy 5 Prenatal Factors Affecting Development 6 Prenatal and Infant Growth 7 Infant Reflexes and Rhythmical Stereotypies 8 Rudimentary Movement Abilities 9 Infant Perception Unit 3 Childhood 10 Childhood Growth and Development 11 Fundamental Movement Abilities 12 Physical Development of Children 13 Childhood Perception and Perceptual-Motor Development 14 Childhood Self-Concept Development Unit 4 Adolescence 15 Adolescent Growth, Puberty, and Reproductive Maturity 16 Specialized Movement Abilities 17 Fitness Changes During Adolescence 18 Adolescent Socialization Unit 5 Adulthood 19 Physiological Changes in Adults 20 Motor Performance in Adults 21 Psychosocial Development in Adults Unit 6 Programming 22 Assessing Motor Behavior 23 Programming for Developmental Physical Activity
Don't lose your bearings

22 HE EFFECTS OF PARASITIC BEARING currents in variable-speed drive systems caused by fast-switching insulated gate bipolar transistor (IGBT) inverters have been reported during the past several years [1]–[24]. In the past, research has focused on physical explanations of the bearing currents for a given drive system at a particular power level. The results presented are based on specific investigations with either small or large motors with respective power ratings of Pr = 1 . 15 kW and Pr ≥ 150 kW. One research lab reported on investigations done on motors with power ratings of Pr = 30 . 70 kW and Pr = 355 kW [20]–[22]. Different mitigation techniques to eliminate inverterinduced bearing currents have also been proposed. The studies reported were done using varied measurement techniques and test setups, rendering forthright comparison of the qualitative and quantitative results difficult. Thus, quantification of the relative weights of the different parameters on the phenomena still requires additional clarification. Such clarification is the goal of this article. A systematic analysis of the qualitative and quantitative influence of different parameters on a variable-speed drive system was carried out. The investigations were conducted under identical conditions on motors rated from 11 to 500 kW T © PHOTODISC
TURNUS: A design exploration framework for dataflow system design

While research on the design of heterogeneous concurrent systems has a long and rich history, a unified design methodology and tool support has not emerged so far, and thus the creation of such systems remains a difficult, time-consuming and error-prone process. The absence of principled support for system evaluation and optimization at high abstraction levels makes the quality of the resulting implementation highly dependent on the experience or prejudices of the designer. This is particularly critical when the combinatorial explosion of design parameters overwhelms available optimization tools. In this work we address these matters by presenting a unified design exploration framework suitable for a wide range of different target platforms. The design is unified and implemented at high level by using a standard dataflow language, while the target platform is described using the IP-XACT standard. This facilitates different design space heuristics that guide the designer during validation and optimization stages without requiring low-level implementations of parts of the application. Our framework currently yields exploration and optimization results in terms of application throughput and buffer size dimensioning, although other co-exploration and optimization heuristics are available.
Suicide risk in relation to psychiatric hospitalization: evidence based on longitudinal registers.

BACKGROUND Persons with a history of admission to a psychiatric hospital are at high risk for suicide, but little is known about how this is influenced by factors related to psychiatric hospitalization. OBJECTIVE To explore suicide risk according to time since admission, diagnosis, length of hospital treatment, and number of prior hospitalizations. DESIGN Nested case-control design. SETTING Individual data are drawn from various Danish longitudinal registers. PARTICIPANTS All 13 681 male and 7488 female suicides committed in Denmark from January 1, 1981, to December 31, 1997, and 423 128 population control subjects matched for sex, age, and calendar time of suicide. Main Outcome Measure Risk of suicide is estimated by conditional logistic regression. Data are adjusted for socioeconomic factors. RESULTS This study demonstrates that there are 2 sharp peaks of risk for suicide around psychiatric hospitalization, one in the first week after admission and another in the first week after discharge; suicide risk is significantly higher in patients who received less than the median duration of hospital treatment; affective disorders have the strongest impact on suicide risk in terms of its effect size and population attributable risk; and suicide risk associated with affective and schizophrenia spectrum disorders declines quickly after treatment and recovery, while the risk associated with substance abuse disorders declines relatively slower. This study also indicates that an admission history increases suicide risk relatively more in women than in men; and suicide risk is substantial for substance disorders and for multiple admissions in women but not in men. CONCLUSIONS Suicide risk peaks in periods immediately after admission and discharge. The risk is particularly high in persons with affective disorders and in persons with short hospital treatment. These findings should lead to systematic evaluation of suicide risk among inpatients before discharge and corresponding outpatient treatment, and family support should be initiated immediately after the discharge.
Carbon monoxide modulates endotoxin-induced microvascular leukocyte adhesion through platelet-dependent mechanisms.

BACKGROUND Although precise mechanisms remain to be determined, recent studies show that heme oxygenase-1 (HO-1), providing endogenous carbon monoxide (CO) and bilirubin, serves as an antiinflammatory enzyme. This study aimed to clarify roles of CO in regulation of microvascular adhesion of platelets and leukocytes in endotoxemia. METHODS Rats pretreated with or without hemin were anesthetized with pentobarbital and received continuous infusion of endotoxin. Platelets labeled with carboxyfluorescein diacetate succinimidyl ester and leukocyte behavior in mesenteric venules were visualized using intravital ultra-high-speed intensified fluorescence videomicroscopy. To examine the mechanisms for the effects of HO-1 on platelet and leukocyte behavior during endotoxemia, these studies were repeated with superfusion of either CO, bilirubin, or zinc protoporphyrine-IX. RESULTS Endotoxin caused a marked depression of platelet velocity traversing along periendothelial regions, accompanied by augmented rolling and adhesion of leukocytes in venules. The endotoxin-elicited changes were attenuated by the HO-1 induction with hemin and restored by blockade of the enzyme activity with zinc protoporphyrine-IX, a potent inhibitor of HO-1. Such an inhibitory action of HO-1 on microvascular cell adhesion was reproduced by local superfusion of the buffer containing CO at micromolar concentrations. Such antiadhesive actions of CO on leukocytes disappeared under immunoneutralization of glycoprotein Ibalpha, an adhesion molecule against platelets, but not against leukocytes. Platelets isolated from hemin-treated rats increased their ability to generate CO and displayed lesser sensitivity of agonist-induced aggregation than those from controls. CONCLUSIONS These results suggest that CO desensitizes endotoxin-induced adhesive responses of leukocytes, mainly through its ability to ameliorate platelet activation.
The Subconscious Effect During Audio Monitoring

Abstract : The purpose of the study was to determine if a subconscious detection effect exists in audio monitoring. The vigilance task consisted of the detection of an audio signal masked by thermal noise. Thirty signals over a sixty minute watch were presented to eighteen military officers who were divided into three equally numbered groups. The control group monitored the tape and this was their primary task. The other two groups were engaged in other primary tasks and were asked to monitor the tape as a secondary task. A statistical examination of the results indicated, at a low probability level of p < . 25, an effect was present causing the groups engaged in monitoring as a secondary task to detect a greater percentage of the signals than the control group. The analysis also indicated that there was a significant decline in performance over time.
Impact analysis of transient stability due to cyber attack on FACTS devices

The innovations in information and communication technologies (ICT) and digital computer controllers are increasingly integrated into the smart grid. This introduces cyberse-curity vulnerabilities which may cause system stability problems. In this paper, the modification attack on SVC and STATCOM in IEEE 39 bus system is simulated with DSAToolsTM. Then the impact on the system transient stability is studied. The results show that some modification cyber attacks can make the system angle or voltage unstable under the proposed attack scenarios.
MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1.

BACKGROUND & AIMS Recent studies have emphasized causative links between microRNA (miRNA) deregulations and cancer development. In hepatocellular carcinoma (HCC), information on differentially expressed miRNA remained largely undefined. METHODS Array-based miRNA profiling was performed on HCC cells that were derived from chronic carriers of hepatitis B virus (HBV) and hepatitis C virus (HCV), and nonviral-associated patients. Specific microRNA (miR)-223 and miR-222 deregulations were verified in an independent series of tumors. The functional effect of miR-223 was examined further. An integrative analysis of messenger RNA (mRNA) array with in silico predictions defined potential downstream targets of miR-223. A luciferase reporter assay was conducted to confirm target association. RESULTS Distinct up-regulations of miR-222, miR-221, and miR-31, and down-regulations of miR-223, miR-126, and miR-122a were identified. Further investigations suggested the highly deregulated miR-223 and miR-222 could unequivocally distinguish HCC from adjacent nontumoral liver, irrespective of viral associations (P <or= .0002). Re-expression of miR-223 in HBV, HCV, and non-HBV non-HCV-related HCC cell lines revealed a consistent inhibitory effect on cell viability (P < .01). Integrative analysis further implicated Stathmin 1 (STMN1) as a downstream target of miR-223. A strong inverse relationship between STMN1 mRNA and miR-223 expressions was shown (P = .006). A substantial reduction in STMN1 protein was further demonstrated upon restoration of miR-223 expression in HCC cell lines. We further showed that miR-223 readily could suppress the luciferase activity in reporter construct containing the STMN1 3' untranslated region (P = .02). CONCLUSIONS Our study revealed specific miRNA differential expressions in HCC and underscores the potential importance of miR-223 down-regulations in the development of HCC.
La especialización hemisférica y la regulación de la conducta motora desde la perspectiva de la neurociencia cognitiva

Introduccion. Nuestra comprension de la organizacion funcional del cerebro se debe a los avances en las tecnicas de neuroimagen y a una intensa investigacion clinica. Recientemente, la ciencia cognitiva (neurociencia cognitiva) en combinacion con los avances tecnologicos han cambiado nuestra comprension sobre la relacion cerebro-conducta. Esta relacion simbiotica ha permitido una mejor caracterizacion del sitio de la lesion en pacientes con trastornos cerebrales y de los patrones de activacion en sujetos sanos. Objetivo. En el presente articulo se discute la contribucion del hemisferio izquierdo y la participacion del hemisferio derecho en la regulacion de la conducta motora; esto nos permitira comprender mejor la lateralizacion de las funciones motoras. Desarrollo. Los resultados apoyan la vision de un predominio del hemisferio izquierdo para el lenguaje y el control motor, y un predominio del hemisferio derecho para las funciones espaciales y la atencion. Las areas especializadas son probablemente predeterminadas y ciertas funciones estan lateralizadas a uno u otro hemisferio, esto debido a la eficiente organizacion y procesamiento de la informacion en el cerebro. Conclusion . En los estudios revisados, se observaron funciones especificas para cada hemisferio, lo que sugiere la existencia de una compleja organizacion que recluta a varias areas del Sistema Nervioso para el adecuado desempeno de una tarea.
Analysis Traceability and Provenance for HEP

This paper presents the use of the CRISTAL software in the N4U project. CRISTAL was used to create a set of provenance aware analysis tools for the Neuroscience domain. This paper advocates that the approach taken in N4U to build the analysis suite is sufficiently generic to be able to be applied to the HEP domain. A mapping to the PROV model for provenance interoperability is also presented and how this can be applied to the HEP domain for the interoperability of HEP analyses.
TDP-43 Is a Developmentally Regulated Protein Essential for Early Embryonic Development*

TDP-43 is a DNA/RNA-binding protein implicated in multiple steps of transcriptional and post-transcriptional regulation of gene expression. Alteration of this multifunctional protein is associated with a number of neurodegenerative diseases including amyotrophic lateral sclerosis and frontotemporal lobar degeneration with ubiquitin positive inclusions. Whereas a pathological link to neurodegenerative disorders has been established, the cellular and physiological functions of TDP-43 remain unknown. In this study, we show that TDP-43 is a nuclear protein with persistent high-level expression during embryonic development and with progressively decreased protein levels during postnatal development. In mice where the TDP-43 gene (Tardbp) was disrupted using a gene trap that carries a β-galactosidase marker gene, heterozygous (Tardbp+/−) mice are fertile and healthy, but intercrosses of Tardbp+/− mice yielded no viable homozygotic null (Tardbp−/−) mice. Indeed, Tardbp−/− embryos die between 3.5 and 8.5 days of development. Tardbp−/− blastocysts grown in cell culture display abnormal expansion of their inner cell mass. The pattern of β-galactosidase staining at E9.5 Tardbp+/− embryos is predominantly restricted to the neuroepithelium and remains prominent in neural progenitors at E10.5–12.5. TDP-43 is detected in spinal cord progenitors and in differentiated motor neurons as well as in the dorsal root ganglia at E12.5. β-Galactosidase staining of tissues from adult Tardbp+/− mice shows widespread expression of TDP-43, including prominent levels in various regions of the central nervous system afflicted in neurodegenerative disorders. These results indicate that TDP-43 is developmentally regulated and indispensible for early embryonic development.