Miracle-dz/UniFAR-FTUs huggingface dataset:
Soundscape Evaluation of a Heritage Event in an Open Environment: The Water Tribunal of the Plain of Valencia (Spain)

The acoustic evaluation of indoor environments is common in the application of virtual acoustics. In addition, in the study of cultural heritage buildings, it is a useful tool, but it is not so common when describing the acoustic environment in intangible cultural heritage events and even in outdoor environments. In this paper, the acoustic environment of the Water Tribunal of the Plain of Valencia (Spain) is studied. It is analyzed from a soundscape perspective, characterizing the sound source and evaluating it within relation to the environment and evaluating its subjective response. With the research carried out, it has been obtained, on the one hand, a complete study of the acoustics of the environment of the Water Tribunal and, on the other, an enhancement of the Valencian tangible and intangible heritage.
Expiration Eﬀect of Leveraged and Inverse ETFs

This study aims to examine whether there is a maturity eﬀect in the leveraged and reverse ETFs on the maturity date of the underlying index futures or on the trading day before and after the maturity date and to investigate whether the maturity eﬀect of diﬀerent types of ETF commodities is more prominent issue. The sample is leverage and inverse ETFs tracking the Taiwan Stock Exchange Capitalization Weighted Stock Index from October 31, 2014 to January 15, 2018. Empirical model used bivariate GARCH model to captures the variations of maturity eﬀects. The study shows that all ETFs present signiﬁcant maturity eﬀects before expiration. In particular, the volatility and trading volume present abnormal phenomenon.
Changes in the Dominant Mode of Summer Precipitation Over the Central‐Eastern Tibetan Plateau Around the Mid‐1990s

The interdecadal changes in the dominant mode of the summer precipitation over the central‐eastern Tibetan Plateau (TP) are investigated around the mid‐1990s. It is found that the leading empirical orthogonal function mode of the interannual variations of summer precipitation over the central‐eastern TP is shown an out‐of‐phase pattern, with opposite variation between the southeastern and northeastern TP during 1961–1996, while the dominant mode become an in‐phase pattern during 1997–2019. During 1961–1996, the dipole pattern of TP precipitation is mainly related to the North Atlantic Oscillation (NAO) and associated circulation anomalies. However, the impact of NAO on the dipole pattern of TP precipitation has weakened since the mid‐1990s. In contrast, during 1997–2019, more pronounced positive height anomalies in the upper troposphere are observed over the whole TP regions. Meanwhile, the southerly moisture flux from the Bay of Bengal and the Philippine Sea is prevalent significantly with strong moisture convergence. Further analysis demonstrates that this interdecadal spatial change is mainly linked to the significant increasing of the sea surface temperature in the North Atlantic, South Atlantic, and Indo‐Pacific warm pool, via wave trains propagation. The wave train‐related positive height anomalies over the TP regions are in favor of the strengthening of the South Asian high (SAH). Moreover, the zonal and meridional mean temperature advections by SAH‐related circulation anomalies are primarily responsible for the intense vertical flow anomalies. Consequently, the summer precipitation anomalies over the entire TP regions are largely enhanced and formed the mono‐sign pattern during 1997–2019.
Molecular Mechanics Simulations and Experimental Investigation of the Effect of Tadalafil on Various Inflammatory Pain Mediators

Purpose: Tadalafil’s exact analgesic mechanism is still unclear. The current study aimed to elucidate this mechanism in an inflammatory pain model. Methods: Computer-assisted simulation docking experiments were carried out to assess the binding of tadalafil to different ligands. The anti-inflammatory and analgesic effects of tadalafil were evaluated using formalin-induced paw edema and a von Frey filament test, respectively. The plantar paw of the mice was then dissected to quantify iNOS, nNOS, COX-2, TNFα, IL1, and IL10 gene expression levels using a real-time polymerase chain reaction. iNOS, TNFα, and COX-2 inhibition was reassessed in vitro using the ELISA technique. One-way analysis of variance followed by post hoc Tukey test or t-test was used to compare the means. Results: Docking analysis showed a superior binding score of tadalafil to COX-2, iNOS, IL-1, and TNF-α compared to that of indomethacin and morphine and a similar binding score to nNOS and IL-10 relative to that of indomethacin. In the in vivo study, tadalafil, after an hour of formalin administration, inhibited significantly paw edema, similar to indomethacin. Furthermore, it significantly increased the withdrawal force in the von Frey filament test as compared to the negative control, which was similar to the effect observed with indomethacin and morphine. The RT-PCR revealed that tadalafil reduced significantly the iNOS, COX-2, and TNF-α gene expressions but had no effect on nNOS, IL 1, and IL10. In vitro ELISA tests confirmed the inhibition of iNOS, COX-2, and TNF-α. Conclusion: Tadalafil probably exerts its analgesic effect through the simultaneous inhibition of iNOS, COX-2, and TNF-α, which is not the case with other nonsteroidal anti-inflammatory drugs. Nevertheless, further studies are required to confirm its mechanism.
Análise dos Estudos de Gerenciamento de Projetos de Jogos Digitais: Uma Revisão Sistemática da Literatura

A indústria de jogos digitais atualmente gera interesse e muitos investimentos. Nesse sentido, torna-se fundamental adotar boas práticas para garantir um ciclo de desenvolvimento de software confiável para alcançar o sucesso do projeto. Fornecemos através desta revisão sistemática de literatura (RSL) referencial empírico para profissionais e pesquisadores que buscam gerenciar projetos de jogos, identificando estudos científicos que apresentem métodos, processos e metodologias para tal finalidade. Iniciamos com 6.658 estudos e na condução dos processos de seleção extraímos dados de 65. Classificamos sete tipos de estudos voltados ao gerenciamento de projetos (GP), dentre estes 64,6% abordam a etapa de levantamento de requisitos, 55,4% definição do jogo e desenvolvimento. A maioria dos pesquisadores são brasileiros e indonésios.
The Relationship of Temperament and Character, Parental Stress, and Mental Health Problems with Attachment Disorders among Children

According to Cloninger’s model, personality is conceptualized in temperament and character traits contributing to a child’s psychosocial development. Additionally, parent–child interaction is important for the child’s socio-emotional development. To date, the relationship between attachment and temperament and character for child mental health development and its effects on parents remains mostly unclear. The aim of the present study was thus to examine the relationship of attachment, temperament and character, parental stress, and mental health problems among 125 children (mean age = 7.14 years) in Switzerland. Temperament and character, attachment disorder (symptoms), parental stress, and mental health problems were assessed with psychometric questionnaires; attachment was assessed with an additional observational measure. Descriptive characters of the sample were presented, and group differences and correlations were computed. For temperament traits, results revealed significant group differences for novelty seeking and persistence and attachment disorder types. For character traits, the findings showed significant group differences for self-directedness and cooperativeness and attachment disorder types. Moderate effect sizes for groups differences were found. Further, the mixed-type (inhibited and disinhibited) and inhibited attachment disorder type were the most burdened groups. The present findings suggest that temperament and character traits, as well as parental stress and mental health problems are associated with the occurrence of attachment disorders among children. Future longitudinal studies with larger samples are needed to examine the causal relationships of temperament and character with attachment, including person-related and environmental factors among children.
Effect of surface structuring onto the efficiency of the in- and out-coupling of light from a chip in Lab-on-a-chip approaches with optical detection

Optical detection methods have been implemented on micro-fluidic chips containing channels or cavities of different geometries e.g. for colorimetry or fluorescence measurements with excitation within the chip plane [1-2]. The most prominent problem of the read-out from a micro-fluidic chip is the limitation of the optical yield. Without e.g. an immersion liquid for compensation of the total reflection on the boundary, only about 11-13% of rays cross over the boundary from a polymer chip to air. One efficient method to increase the optical yield from a chip is a ray reorientation inside of the chip using an additional surface structure creating new incident refraction conditions on the boundary before rays are leaving the chip. The use of 45°-tilted mirror arrangements for in- and out-coupling of the fluorescence signal from a micro-fluidic chip and the realization of this principle for low-cost fluorescence detection systems have been published [3]. This paper includes the investigation of the effect of different tilt angles of total reflection and metallized-surface mirrors for an analyte volume emitter, using the ray-tracing simulation tool OptiCAD10. Furthermore, an estimation of the influence of a surface-emitted signal for different geometries of metallized detection cells with or without a combination with external lenses on the out-coupling efficiency will be presented. The best result of an out-coupling efficiency increase of 10 times was achieved for a combination of a structured and metallized detection cell with an external cylindrical lens.
A short-term planning model for high-speed train assignment and maintenance scheduling

This paper considers the simultaneous high-speed train assignment and maintenance scheduling problem. For the maintenance scheduling module, our focus is the second-level maintenance, which is carried out once a month on average. We propose a binary non-linear programming model to mathematically describe the problem. The objective aims to minimize the mileage losses for all high-speed trains and the constraints cover various operational requirements and capacity restrictions. To model the difficult operational requirements, a novel cumulative mileage update function is developed; meanwhile, to describe the depot maintenance capacity restriction, we employ a state function that is able to identify whether a train is in the maintenance state or in the operation state.
Single‐Crystal Elasticity of Phase E at High Pressure and Temperature: Implications for the Low‐Velocity Layer Atop the 410‐km Depth

Dense hydrous magnesium silicate (DHMS) phase E is a potential water carrier in subducting slabs that can transport water to the Earth's deep mantle between the bottom of the upper mantle and the uppermost transition zone. Therefore, knowledge on the high pressure‒temperature (P‒T) full elastic moduli of phase E at relevant mantle conditions is important in deciphering the existence of DHMS phases and their influences on seismic profiles in the region; however, the high P‒T elasticity data of phase E still remains lacking. In this work, we determined the combined effect of P‒T on the single‐crystal elasticity of phase E up to 24 GPa and 900 K by in situ X‐ray diffraction and Brillouin scattering measurements in externally‐heated diamond anvil cells. The aggregate elastic moduli and compressional‐wave (VP) and shear‐wave (VS) velocities of phase E are then derived by analyzing the single‐crystal elasticity and density data using the third‐order finite‐strain equations. We found that phase E exhibits much lower bulk and shear moduli and acoustic velocities than the most abundant constituent minerals in the upper mantle and transition zone, such as olivine, clinopyroxene, garnet, and wadsleyite. The modeled results using the obtained elasticity results show that the existence of phase E in a hydrated pyrolite model can result in relatively lower Vp and Vs profiles and negative velocity anomalies in seismic observations. The existence of phase E with relatively lower velocity profiles could be a possible origin of the low‐velocity layers atop the 410‐km discontinuity in some cold and highly‐hydrated regions.
A multiscale approach for spatially inhomogeneous disease dynamics

In this paper we introduce an agent-based epidemiological model that generalizes the classical SIR model by Kermack and McKendrick. We further provide a multiscale approach to the derivation of a macroscopic counterpart via the mean-field limit. The chain of equations acquired via the multiscale approach are investigated, analytically as well as numerically. The outcome of these results provide strong evidence of the models' robustness and justifies their applicability in describing disease dynamics, in particularly when mobility is involved.
Radiative Gas Dynamic Model of Hydrogen Laser-Supported Plasma Generator

Radiative gas dynamics of a hydrogen laser-supported plasma generator and radiative heating of the internal surface of the plasma generator are studied numerically. For this purpose, a radiative gas dynamic model of the laser-supported wave in the cylindrical channel of the laser-supported plasma generator is created. The model is based on the Navier-Stokes equations, energy conservation equation for heat conducting gas in chemical equilibrium, and the radiation heat transfer equation using the multigroup spectral approximation. The numerical study is performed for the typical parameters of the laser-supported plasma generator: input velocities u 0 = 10-200 m/s, pressure p = 1 atm, and CW CO 2 laser radiation power P L = 100-200 kW.
Minima distribution for global optimization

This paper establishes a strict mathematical relationship between an arbitrary continuous function on a compact set and its global minima, like the well-known first order optimality condition for convex and differentiable functions. By introducing a class of nascent minima distribution functions that is only related to the target function and the given compact set, we construct a sequence that monotonically converges to the global minima on that given compact set. Then, we further consider some various sequences of sets where each sequence monotonically shrinks from the original compact set to the set of all global minimizers, and the shrink rate can be determined for continuously differentiable functions. Finally, we provide a different way of constructing the nascent minima distribution functions.
Minimal Connectivity

A k-connected graph such that deleting any edge / deleting any vertex / contracting any edge results in a graph which is not k-connected is called minimally / critically / contraction-critically k-connected. These three classes play a prominent role in graph connectivity theory, and we give a brief introduction with a light emphasis on reduction- and construction theorems for classes of k-connected graphs.
Scope and mortality of adult medical ICU patients in an Eastern Cape tertiary hospital

Background The characteristics and mortality outcomes of patients admitted to South African intensive care units (ICUs) owing to medical conditions are unknown. Available literature is derived from studies based on data from high-income countries. Objectives To determine ICU utilisation by medical patients and evaluate the scope of admissions and clinical associations with hospital mortality in ICU patients 12 years and older admitted to an Eastern Cape tertiary ICU, particularly in the subset with HIV disease. Methods A retrospective descriptive one-year cohort study. Data were obtained from the LivAKI study database and demographic data, comorbidities, diagnosis, and mortality outcomes and associations were determined. Results There were 261 (29.8%) medical ICU admissions. The mean age of the cohort was 40.2 years; 51.7% were female. When compared with the surgical emergencies, the medical subgroup had higher sequential organ failure assessment (SOFA) scores (median score 5 v. 4, respectively) and simplified acute physiology score III (SAPS 3) scores (median 52.7 v. 48.5), a higher incidence of acute respiratory distress syndrome (ARDS) (7.7% v. 2.9%) and required more frequent dialysis (20.3% v. 5.5%). Of the medical admissions, sepsis accounted for 32.4% of admission diagnoses. The HIV seroprevalence rate was 34.0%, of whom 57.4% were on antiretroviral therapy. ICU and hospital mortality rates were 11.1% and 21.5% respectively, while only acute kidney injury (AKI) and sepsis were independently associated with mortality. The HIV-positive subgroup had a higher burden of tuberculosis (TB), higher admission SOFA and SAPS 3 scores and required more organ support. Conclusion Among medical patients admitted to ICU, there was a high HIV seroprevalence with low uptake of antiretroviral therapy. Sepsis was the most frequently identified ICU admission diagnosis. Sepsis and AKI (not HIV) were independent predictors of mortality. Co-infection with HIV and TB was associated with increased mortality. Contributions of the study The epidemiology and outcomes of adults who are critically ill from medical conditions in South African intensive care units was previously unknown but has been described in this study. The association of sepsis, TB, HIV and acute kidney injury with mortality is discussed.
Analysis of a Recurrence Related to Critical Nonhomogeneous Branching Processes

Abstract Some classes of controlled branching processes (with nonhomo-geneous migration or with nonhomo-geneous state-dependent immigration) lead in the critical case to a recurrence for the extinction probabilities. Under some additional conditions it is known that this recurrence depends on some parameter β and converges for 0 < β < 1. Now we show that the recurrence does converge for all positive values of the parameter β, which leads to an extension of some limit theorems for the corresponding branching processes. We also give a generalization of the recurrence and an asymptotic analysis of its behavior.
Optimal design for thermodynamic system with OpenModelica and MATLAB/Simulink

The complicated thermodynamic system includes nonlinear characteristics and is expressed by high order differential algebraic equations. Therefore, it is difficult to carry out numerical analysis such as optimization. To deal with this problem, we verify an integrated design support environment incorporating OpenModelica for a centrifugal chiller as an example. In this paper, it is shown that the parameters of the model and the control logic can be adjusted by the coupled simulation of the chiller model written in the Modelica language and the control logic on MATLAB/Simulink. We also simplify the centrifugal chiller model by approximating the nonlinear characteristics with a smooth polynomial, and by reducing the order of the differential algebraic equation by the Pantelides method. Then, a case study of a startup profile optimization is shown.
Partial melting and reaction along deformation features in plagioclase

Geological processes involving deformation and/or reactions are highly influenced by the rock grain size, especially if diffusion‐controlled processes take place such as metamorphic reactions and diffusion creep. Although many processes, inducing grain‐size reduction, are documented and understood at relatively high stresses and low temperatures (e.g., cataclasis) as well as at lower stress and higher temperature conditions (e.g., bulging and subgrain rotation), deformation twinning, a plastic deformation mechanism active in various minerals at lower temperatures, has been neglected as nucleation site for melting and reaction and thus as a cause for grain‐size reduction so far. We conducted experiments on natural plagioclase‐bearing aggregates at 2.5 to 3 GPa confining pressure and temperatures of 700°C to 950°C using two different deformation apparatus, a deformation multianvil apparatus (DDIA) and a Griggs press, as well as a piston‐cylinder apparatus. Regardless of the apparatus type, we observe the breakdown of plagioclase into an eclogite‐facies paragenesis, which is associated with partial melting in the high temperature domain of the eclogite facies. Partial melting mostly takes place along the grain and interphase boundaries. However, several melt patches or plagioclase decomposition products coincide with the occurrence of deformation twins and grain‐scale microcracking in plagioclase indicating intracrystalline melting and reaction in addition to melting and reaction along grain and interphase boundaries. In the present study, we demonstrate how the interplay between brittle microcracking and plastic deformation twinning can cause intracrystalline melting and/or reaction, which has the potential to lower the effective grain size of plagioclase‐rich rocks and thus impacts their reactivity and deformation behaviour.
Effects of aqueous and ethanolic extracts of Lepidium meyenii Walp (red and black maca) on Caenorhabditis elegans

Lepidium meyenii (maca) is a Peruvian nutraceutical plant, whose hypocotyl has a variety of colors ranging from black to white. The black and red varieties of maca have been the most studied since their extracts are associated with effects such as increased sperm count, decreased glucose levels, reversal of prostatic hyperplasia, among others. However, the properties related to reduction of oxidative stress, metabolic diseases and anti-aging have not yet been confirmed. The aim was to evaluate the effects of aqueous and ethanolic extracts, obtained from spray-dried hydroalcoholic extract of hypocotyl of black and red maca (Lepidium meyenii), on mortality, growth, reproduction, lipid accumulation and the expression levels of genes related to oxidative stress and heat shock, in the in-vivo model, Caenorhabditis elegans (C. elegans), using different concentrations. The results showed that maca extracts were not toxic to the model at concentrations below 100 mg L-1. However, higher concentrations caused high mortality, growth disturbances, oxidative stress and lipid accumulation. Black maca extracts increased the reproduction of C. elegans by increasing the number of offspring in C. elegans, both in aqueous and ethanolic extracts. On the other hand, ethanolic extracts produced an increase in the expression of genes related to oxidative stress, indicating a mild stressor behavior of the same. C. elegans represents an established model for evaluating the biological properties of nutraceutical plants of biological interest and can be used in the search for antioxidant activity of L. meyenii (hypocotyl), as well as it can be used in future studies to identify some metabolites involved in each biological property and to understand the biochemical and molecular mechanisms involved in these properties.