Miracle-dz/UniFAR-FTUs huggingface dataset:
Automated analysis of performance and energy consumption for cloud applications

In cloud environments, IT solutions are delivered to users via shared infrastructure. One consequence of this model is that large cloud data centres consume large amounts of energy and produce significant carbon footprints. A key objective of cloud providers is thus to develop resource provisioning and management solutions at minimum energy consumption while still guaranteeing Service Level Agreements (SLAs). However, a thorough understanding of both system performance and energy consumption patterns in complex cloud systems is imperative to achieve a balance of energy efficiency and acceptable performance. In this paper, we present StressCloud, a performance and energy consumption analysis tool for cloud systems. StressCloud can automatically generate load tests and profile system performance and energy consumption data. Using StressCloud, we have conducted extensive experiments to profile and analyse system performance and energy consumption with different types and mixes of runtime tasks. We collected fine-grained energy consumption and performance data with different resource allocation strategies, system configurations and workloads. The experimental results show the correlation coefficients of energy consumption, system resource allocation strategies and workload, as well as the performance of the cloud applications. Our results can be used to guide the design and deployment of cloud applications to balance energy and performance requirements.
Differences Between Children and Adults: Implications for Risk Assessment at California EPA

The California legislature enacted a law requiring the California Environmental Protection Agency (Cal/EPA) Office of Environmental Health Hazard Assessment (OEHHA) to evaluate whether our risk assessment methodologies are adequately protective of infants and children. In addition both OEHHA and the California Air Resources Board must examine whether the Ambient Air Quality Standards set for criteria air pollutants and the health values developed for air toxics are adequately protective of infants and children. We have initiated a program to look at potential differences in response to toxicants between children and adults. We are evaluating this issue from the perspective of exposure differences as well as toxicokinetic and toxicodynamic differences between children and adults. Data on specific chemicals are rather limited. As a result, we will be pooling information to determine whether there are generic differences between children and adults that may be applicable to risk assessment in general or to risk assessment of specific classes of compounds. This paper discusses the rationale for approaching the issue of determining whether our risk assessment methods are adequate for infants and children and includes a discussion of some of the available information on both qualitative and quantitative differences in response to toxicants between children and adults or immature and mature laboratory animals. We provide examples of differences between children and adults in absorption, metabolism, and excretion of toxicants as well as qualitative differences in toxic response.
Allometric scaling of metabolic rate from molecules and mitochondria to cells and mammals

The fact that metabolic rate scales as the three-quarter power of body mass (M) in unicellular, as well as multicellular, organisms suggests that the same principles of biological design operate at multiple levels of organization. We use the framework of a general model of fractal-like distribution networks together with data on energy transformation in mammals to analyze and predict allometric scaling of aerobic metabolism over a remarkable 27 orders of magnitude in mass encompassing four levels of organization: individual organisms, single cells, intact mitochondria, and enzyme molecules. We show that, whereas rates of cellular metabolism in vivo scale as M−1/4, rates for cells in culture converge to a single predicted value for all mammals regardless of size. Furthermore, a single three-quarter power allometric scaling law characterizes the basal metabolic rates of isolated mammalian cells, mitochondria, and molecules of the respiratory complex; this overlaps with and is indistinguishable from the scaling relationship for unicellular organisms. This observation suggests that aerobic energy transformation at all levels of biological organization is limited by the transport of materials through hierarchical fractal-like networks with the properties specified by the model. We show how the mass of the smallest mammal can be calculated (≈1 g), and the observed numbers and densities of mitochondria and respiratory complexes in mammalian cells can be understood. Extending theoretical and empirical analyses of scaling to suborganismal levels potentially has important implications for cellular structure and function as well as for the metabolic basis of aging.
The Calcium Channel C-Terminal and Synaptic Vesicle Tethering: Analysis by Immuno-Nanogold Localization

At chemical synapses the incoming action potential triggers the influx of Ca2+ through voltage-sensitive calcium channels (CaVs, typically CaV2.1 and 2.2) and the ions binds to sensors associated with docked, transmitter filled synaptic vesicles (SVs), triggering their fusion and discharge. The CaVs and docked SVs are located within the active zone (AZ) region of the synapse which faces a corresponding neurotransmitter receptor-rich region on the post-synaptic cell. Evidence that the fusion of a SV can be gated by Ca2+ influx through a single CaV suggests that the channel and docked vesicle are linked by one or more molecular tethers (Stanley, 1993). Short and long fibrous SV-AZ linkers have been identified in presynaptic terminals by electron microscopy and we recently imaged these in cytosol-vacated synaptosome ‘ghosts. ’ Using CaV fusion proteins combined with blocking peptides we previously identified a SV binding site near the tip of the CaV2.2 C-terminal suggesting that this intracellular channel domain participates in SV tethering. In this study, we combined the synaptosome ghost imaging method with immunogold labeling to localize CaV intracellular domains. L45, raised against the C-terminal tip, tagged tethered SVs often as far as 100 nm from the AZ membrane whereas NmidC2, raised against a C-terminal mid-region peptide, and C2Nt, raised against a peptide nearer the C-terminal origin, resulted in gold particles that were proportionally closer to the AZ. Interestingly, the observation of gold-tagged SVs with NmidC2 suggests a novel SV binding site in the C-terminal mid region. Our results implicate the CaV C-terminal in SV tethering at the AZ with two possible functions: first, capturing SVs from the nearby cytoplasm and second, contributing to the localization of the SV close to the channel to permit single domain gating.
Image registration and multimodal imaging of reticular pseudodrusen.

PURPOSE To characterize reticular pseudodrusen (RPD) by using a point-to-point comparison of the reticular pattern on infrared reflectance (IR), autofluorescence (AF), and red-free (RF) images registered with en face sections of the choroid from spectral domain optical coherence tomography (SD-OCT) scans. METHODS A cross-sectional, retrospective study of all patients with the diagnosis of AMD who presented to the Doheny Retina Institute between December 2007 and November 2009 was conducted to identify patients with RPD. IR, AF, and RF images were obtained using confocal scanning laser ophthalmoscopy and were manually registered to OCT choroidal sections to study the location of RPD. The main outcome measured was point-to-point localization of RPD across multiple imaging modalities. RESULTS Of the 153 patients with AMD, 51 had RPD. In all 51 patients (97 eyes), RPD appeared as areas of hypoautofluorescence and hyporeflectance on AF and IR imaging, respectively, and as hyporeflective interlacing networks on RF. Reticular lesions on AF, IR, and RF images consistently colocalized with stromal regions between large choroidal vessels on registered en face choroidal sections. In contrast, outer retinal changes and subretinal deposits tended to localize immediately adjacent to the RPD. CONCLUSIONS Point-to-point correlation of registered IR, AF, and RF images consistently localizes the reticular pattern to the intervascular choroidal stroma on en face OCT sections. In contrast, subretinal deposits and disturbances of the inner outer segment on OCT did not colocalize with the RPD, and may represent secondary mechanical or biologic disturbances in the overlying RPE and outer retina.
Volunteered Geographic Information: the nature and motivation of produsers

Advances in positioning, Web mapping, cellular communications and wiki technologies have surpassed the original visions of GSDI programs around the world. By tapping the distributed knowledge, personal time and energy of volunteer contributors, GI voluntarism is beginning to relocate and redistribute selected GI productive activities from mapping agencies to networks of non-state volunteer actors. Participants in the production process are both users and producers, or ‘produsers’ to use a recent neologism. Indeed, GI voluntarism ultimately has the potential to redistribute the rights to define and judge the value of the produced geographic information and of the new production system in general. The concept and its implementation present a rich collection of both opportunities and risks now being considered by leaders of public and private mapping organizations world-wide. In this paper, the authors describe and classify both the types of people who volunteer geospatial information and the nature of their contributions. Combining empirical research dealing with the Open Source software and Wikipedia communities with input from selected national mapping agencies and private companies, the authors offer different taxonomies that can help researchers clarify what is at stake with respect to geospatial information contributors. They identify early lessons which may be drawn from this research, and suggest questions which may be posed by large mapping organizations when considering the potential opportunities and risks associated with encouraging and employing Volunteered Geographic Information in their programs.
Moderate Champagne consumption promotes an acute improvement in acute endothelial-independent vascular function in healthy human volunteers

Epidemiological studies have suggested an inverse correlation between red wine consumption and the incidence of CVD. However, Champagne wine has not been fully investigated for its cardioprotective potential. In order to assess whether acute and moderate Champagne wine consumption is capable of modulating vascular function, we performed a randomised, placebo-controlled, cross-over intervention trial. We show that consumption of Champagne wine, but not a control matched for alcohol, carbohydrate and fruit-derived acid content, induced an acute change in endothelium-independent vasodilatation at 4 and 8 h post-consumption. Although both Champagne wine and the control also induced an increase in endothelium-dependent vascular reactivity at 4 h, there was no significant difference between the vascular effects induced by Champagne or the control at any time point. These effects were accompanied by an acute decrease in the concentration of matrix metalloproteinase (MMP-9), a significant decrease in plasma levels of oxidising species and an increase in urinary excretion of a number of phenolic metabolites. In particular, the mean total excretion of hippuric acid, protocatechuic acid and isoferulic acid were all significantly greater following the Champagne wine intervention compared with the control intervention. Our data suggest that a daily moderate consumption of Champagne wine may improve vascular performance via the delivery of phenolic constituents capable of improving NO bioavailability and reducing matrix metalloproteinase activity.
Target Selection: Choice or Response?

The posterior parietal cortex (PPC) encodes information related to action ([Desmurget et al., 1999][1]). A subregion of the PPC, the parietal reach region (PRR), is involved in encoding the direction of volitional reaching movements to seen ([Snyder et al., 1997][2]) and unseen ([Gail and Andersen,
Cell-Surface Association between Progelatinases and beta² Integrins: Role of the Complexes in Leukocyte Migration

REVIEW OF THE LITERATURE LEUKOCYTE ADHESION AND MIGRATION THE LEUKOCYTE MIGRATION CASCADE NEUTROPHIL FUNCTION AND ADHESION DURING INFLAMMATION Granulopoiesis and subsets of neutrophil granules INTEGRINS AND THEIR LIGANDS Structure and function of leukocyte β2 integrins Activation of leukocyte β2 integrins MATRIX METALLOPROTEINASES CLASSIFICATION OF MMPs STRUCTURAL FEATURES OF MMPs REGULATION OF MMPS Transcriptional regulation Zymogen activation Inhibition of enzymatic activity ROLE OF INTEGRINS AND MMPs IN LEUKOCYTE MIGRATION REGULATION OF LEUKOCYTE ADHESION AND MIGRATION CELL-SURFACE ASSOCIATION OF MMPs AND OTHER PROTEASES ROLE OF INTEGRINS AND GELATINASES IN CANCER AND INFLAMMATION INTEGRINS AND GELATINASES in tumor angiogenesis and growth INTEGRINS AND GELATINASES in invasion and metastasis INTEGRINS AND GELATINASES in cancer associated-inflammation ROLE OF INTEGRINS AND GELATINASES IN ACUTE LEUKEMIAS THERAPEUTIC INTERVENTION WITH MMP AND INTEGRIN INHIBITORS AIMS OF THE PRESENT STUDY MATERIALS AND METHODS
Is Perfect Price Discrimination Really Efficient? An Analysis of Free Entry

We analyze models of product differentiation with perfect price discrimination and free entry. With a fixed number of firms, and in the absence of coordination failures, perfect price discrimination provides incentives for firms to choose product characteristics in a socially optimal way. However, with free entry, the number of firms is always excessive. Our results apply to a large class of models of product differentiation. They also apply to models of common agency or lobbying with free entry and imply that one has excessive entry into the ranks of the principals.
Factors that may impede the weight loss response to exercise‐based interventions

The results of exercise programmes designed to reduce body fat are disappointing. However, the reporting of weight loss as mean values disguises those individuals who do lose significant amounts of fat. Why some participants produce significant exercise‐induced fat loss whereas others lose little or increase fat stores is likely to be an outcome of a range of behavioural (e.g. sleep deprivation, caloric intake), inherited (e.g. muscle fibre type, gender) and physiological (e.g. hyperinsulinaemia, hypothyroidism) factors. The following review highlights possible factors involved in weight loss and discusses how individual differences may determine the extent of weight loss after an exercise intervention. Finally, implications for the treatment and prevention of obesity are discussed.
Risk of Cancer in Diabetes: The Effect of Metformin

Cancer is the second cause of death. Association of diabetes as a growing and costly disease with cancer is a major health concern. Meanwhile, preexisting diabetes is associated with an increased risk of all-cause and cancer-specific mortalities. Presence of diabetes related comorbidities, poorer response to cancer treatment, and excess mortality related to diabetes are among the most important explanations. Although diabetes appear to be a risk factor for cancer and is associated with the mortality risk in cancer patients, several factors such as diabetes duration, multiple drug therapy, and the presence of diabetes comorbidities make the assessment of the effect of diabetes treatment on cancer risk and mortality difficult. Metformin is the drug of choice for the treatment of type 2 diabetes. The available evidence from basic science, clinical, and population-based research supports the anticancer effect of metformin. However, randomized controlled clinical trials do not provide enough evidence for a strong protective effect of metformin on cancer incidence or mortality. One of the most important limitations of these trials is the short duration of the followup. Further long-term randomized controlled clinical trials specifically designed to determine metformin effect on cancer risk are needed to provide the best answer to this challenge.
Selective Inference for Sparse High-Order Interaction Models

Finding statistically significant high-order interactions in predictive modeling is important but challenging task because the possible number of high-order interactions is extremely large (e.g., > 1017). In this paper we study feature selection and statistical inference for sparse high-order interaction models. Our main contribution is to extend recently developed selective inference framework for linear models to high-order interaction models by developing a novel algorithm for efficiently characterizing the selection event for the selective inference of high-order interactions. We demonstrate the effectiveness of the proposed algorithm by applying it to an HIV drug response prediction problem.
The development of the field of HRD: a Delphi study

Purpose – The study explored the views of leading human resource development (HRD) academics regarding five main issues: the disciplinary bases of HRD, the historical milestones in HRD, the constituent components of HRD, the leading contributions in terms of journal articles and books to the development of HRD and the future of HRD.Design/methodology/approach – A Delphi methodology was adopted. The views of editorial board members of the four main HRD journals (Human Resource Development Quarterly, Human Resource Development International, Advances in Developing Human Resources, Human Resource Development Review) and of the Board of Directors of the Academy of Human Resource Development were sought.Findings – Adult learning, systems theory and psychology were identified as the disciplinary bases of HRD. Works by Knowles, Nadler and McLagan were viewed as the leading contributions to the field. Adjusting to changes in work patterns and how work is organized was identified as a key trend influencing the fie.
Approximate Structural Context Matching: An Approach to Recommend Relevant Examples

When coding to an application programming interface (API), developers often encounter difficulties, unsure of which class to subclass, which objects to instantiate, and which methods to call. Example source code that demonstrates the use of the API can help developers make progress on their task. This paper describes an approach to provide such examples in which the structure of the source code that the developer is writing is matched heuristically to a repository of source code that uses the API. The structural context needed to query the repository is extracted automatically from the code, freeing the developer from learning a query language or from writing their code in a particular style. The repository is generated automatically from existing applications, avoiding the need for handcrafted examples. We demonstrate that the approach is effective, efficient, and more reliable than traditional alternatives through four empirical studies
Circular Jacobi Ensembles and Deformed Verblunsky Coefficients

Using the spectral theory of unitary operators and the theory of orthogonal polynomials on the unit circle, we propose a simple matrix model for the following circular analogue of the Jacobi ensemble: $$c_{\delta,\beta}^{(n)} \prod_{1\leq k -1/2$. If $e$ is a cyclic vector for a unitary $n\times n$ matrix $U$, the spectral measure of the pair $(U,e)$ is well parameterized by its Verblunsky coefficients $(\alpha_0, ., \alpha_{n-1})$. We introduce here a deformation $(\gamma_0, >., \gamma_{n-1})$ of these coefficients so that the associated Hessenberg matrix (called GGT) can be decomposed into a product $r(\gamma_0). r(\gamma_{n-1})$ of elementary reflections parameterized by these coefficients. If $\gamma_0, . , \gamma_{n-1}$ are independent random variables with some remarkable distributions, then the eigenvalues of the GGT matrix follow the circular Jacobi distribution above. These deformed Verblunsky coefficients also allow to prove that, in the regime $\delta = \delta(n)$ with $\delta(n)/n \to \dd$, the spectral measure and the empirical spectral distribution weakly converge to an explicit nontrivial probability measure supported by an arc of the unit circle. We also prove the large deviations for the empirical spectral distribution. Formula with Formula . If e is a cyclic vector for a unitary n x n matrix U, the spectral measure of the pair (U, e) is well parameterized by its Verblunsky coefficients ({alpha}0, ., {alpha}n–1). We introduce here a deformation ({gamma}0, ., {gamma}n–1) of these coefficients so that the associated Hessenberg matrix (called GGT) can be decomposed into a product r({gamma}0)··· r({gamma}n–1) of elementary reflections parameterized by these coefficients. If {gamma}0, . , {gamma}n–1 are independent random variables with some remarkable distributions, then the eigenvalues of the GGT matrix follow the circular Jacobi distribution above. These deformed Verblunsky coefficients also allow us to prove that, in the regime {delta} = {delta} (n) with {delta} (n)/ n -> β d/2, the spectral measure and the empirical spectral distribution weakly converge to an explicit nontrivial probability measure supported by an arc of the unit circle. We also prove the large deviations for the empirical spectral distribution.
Frequent In Vitro Recombination in Internal Transcribed Spacers 1 and 2 during Genotyping of Pneumocystis jirovecii

ABSTRACT Pneumocystis jirovecii is the causative agent of Pneumocystis pneumonia (PCP) in immunocompromised persons. Knowledge of the transmission and epidemiology of PCP is still incipient, and investigations on these subjects are based exclusively on applications of molecular typing techniques. The polymorphic internal transcribed spacers ITS1 and ITS2 in the ribosomal DNA operon, which in the P. jirovecii genome exist as single-copy DNA, are commonly used as target loci for isolate typing. In the course of genotyping P. jirovecii in respiratory specimens from PCP patients by amplification and cloning of a large number of ITS sequences, we found mixed infections (two or more types) in 50% of the samples. In a majority of the specimens with mixed infections, we detected many ITS haplotypes (combinations of ITS1 and ITS2 types) that appeared to be products of recombination between globally common ITS haplotypes present in the same sample. Here we present results of a series of experiments showing that essentially all ITS recombinants are chimeras formed during the genotyping process. Under standard conditions, as many as 37% of the amplified sequences could be hybrid DNA artifacts. We show that by modifying PCR amplification conditions, ITS chimera formation could be largely abolished and the erroneous establishment of artifactual haplotypes avoided. The accurate assessment of genetic diversity is fundamental for a better understanding of the epidemiology and biology of P. jirovecii infections.