Miracle-dz/UniFAR-FTUs huggingface dataset:
The Extended Toda Hierarchy

We present the Lax pair formalism for certain extension of the continuous limit of the classical Toda lattice hierarchy, provide a well defined notion of tau function for its solutions, and give an explicit formulation of the relationship between the CP 1 topological sigma model and the extended Toda hierarchy. We also establish an equivalence of the latter with certain extension of the nonlinear
Conserved DNA methylation patterns in healthy blood cells and extensive changes in leukemia measured by a new quantitative technique

Genome wide analysis of DNA methylation provides important information in a variety of diseases, including cancer. Here, we describe a simple method, Digital Restriction Enzyme Analysis of Methylation (DREAM), based on next generation sequencing analysis of methylation-specific signatures created by sequential digestion of genomic DNA with SmaI and XmaI enzymes. DREAM provides information on 150,000 unique CpG sites, of which 39,000 are in CpG islands and 30,000 are at transcription start sites of 13,000 RefSeq genes. We analyzed DNA methylation in healthy white blood cells and found methylation patterns to be remarkably uniform. Inter individual differences > 30% were observed only at 227 of 28,331 (0.8%) of autosomal CpG sites. Similarly, > 30% differences were observed at only 59 sites when we comparing the cord and adult blood. These conserved methylation patterns contrasted with extensive changes affecting 18–40% of CpG sites in a patient with acute myeloid leukemia and in two leukemia cell lines. The method is cost effective, quantitative (r2 = 0.93 when compared with bisulfite pyrosequencing) and reproducible (r2 = 0.997). Using 100-fold coverage, DREAM can detect differences in methylation greater than 10% or 30% with a false positive rate below 0.05 or 0.001, respectively. DREAM can be useful in quantifying epigenetic effects of environment and nutrition, correlating developmental epigenetic variation with phenotypes, understanding epigenetics of cancer and chronic diseases, measuring the effects of drugs on DNA methylation or deriving new biological insights into mammalian genomes.
Omega-3 Long-Chain Polyunsaturated Fatty Acids and Preeclampsia: Trials Say “No,” but Is It the Final Word?

Preeclampsia is a dangerous disorder of pregnancy, defined as hypertension with proteinuria. Its nature remains elusive, and measures of prevention and treatment are limited. Observational studies have suggested that preeclampsia is associated with low intake of omega-3 long-chain polyunsaturated fatty acids (LCPUFA). In recent decades, researchers studied LCPUFA supplementation as a measure to prevent preeclampsia. Most of these trials and later systematic reviews yielded negative results. However, these trials had several important limitations associated with heterogeneity and other issues. Recent research suggests that preeclampsia trials should take into consideration the gender of the fetus (and thus sexual dimorphism of placenta), the positive effect of smoking on preeclampsia prevalence, and the possibility that high doses of LCPUFA mid-term or later may promote the disorder instead of keeping it at bay. In this review, we discuss these issues and future prospects for LCPUFA in preeclampsia research.
Cognitive maps as orienting schemata.

A "point-to-unseen-targets" task was used to test two theories about the nature of cognitive mapping. The hypothesis that a cognitive map is like a "picture in the head" predicts that (a) the cognitive map should have a preferred orientation and (b) all coded locations should be equally available. These predictions were confirmed in Experiments 1 and 3 when targets were cities in the northeastern United States and learning was from a map. The theory that a cognitive map is an orienting schema predicts that the cognitive map should have no preferred orientation and that targets in front of the body should be localized faster than targets behind the body. These predictions were confirmed in Experiments 1 and 2 when targets were local landmarks that had been learned via direct experience. In Experiment 3, when cities in the Northeast were targets and geographical knowledge had been acquired, in part, by traveling in the Northeast, the observed latency profiles were not as predicted by either theory of cognitive mapping. The results suggest that orienting schemata direct orientation with respect to local environments, but that orientation with respect to large geographical regions is supported by a different type of cognitive structure. Language: en
Patterns of phrenic motor output evoked by chemical stimulation of neurons located in the pre-Bötzinger complex in vivo.

The pre-Bötzinger complex (pre-BötC) has been proposed to be essential for respiratory rhythm generation from work in vitro. Much less, however, is known about its role in the generation and modulation of respiratory rhythm in vivo. Therefore we examined whether chemical stimulation of the in vivo pre-BötC manifests respiratory modulation consistent with a respiratory rhythm generator. In chloralose- or chloralose/urethan-anesthetized, vagotomized cats, we recorded phrenic nerve discharge and arterial blood pressure in response to chemical stimulation of neurons located in the pre-BötC with DL-homocysteic acid (DLH; 10 mM; 21 nl). In 115 of the 122 sites examined in the pre-BötC, unilateral microinjection of DLH produced an increase in phrenic nerve discharge that was characterized by one of the following changes in cycle timing and pattern: 1) a rapid series of high-amplitude, rapid rate of rise, short-duration bursts, 2) tonic excitation (with or without respiratory oscillations), 3) an integration of the first two types of responses (i.e., tonic excitation with high-amplitude, short-duration bursts superimposed), or 4) augmented bursts in the phrenic neurogram (i.e., eupneic breath ending with a high-amplitude, short-duration burst). In 107 of these sites, the phrenic neurogram response was accompanied by an increase or decrease (>/=10 mmHg) in arterial blood pressure. Thus increases in respiratory burst frequency and production of tonic discharge of inspiratory output, both of which have been seen in vitro, as well as modulation of burst pattern can be produced by local perturbations of excitatory amino acid neurotransmission in the pre-BötC in vivo. These findings are consistent with the proposed role of this region as the locus for respiratory rhythm generation.
Locally-connected Hierarchical Neural Networks for GPU-accelerated Object Recognition

Convolutional neural networks have achieved good recognition results on image datasets while being computationally efficient, i.e., scaling well with the number of training patterns and the resolution of the patterns. Here we investigate a neural network model that has a similar hierarchical structure, but does not employ weight sharing. Instead, each neuron has a fixed receptive field with unique connection weights. To deal with the enormous number of weights resulting from this architecture, we implemented a parallel version of the model using Nvidia’s CUDA framework. This implementation is up to 82 times faster than a serial CPU implementation. Our model achieves state-of-the-art recognition performance on the NORB normalized-uniform dataset (2.87% error rate) and good results on the MNIST dataset (0.76% error rate). This suggests that large networks with local, non-shared connections might be an interesting architecture for object recognition tasks. To further evaluate the model, we created a large, publicly available training and testing set, which consists of objects extracted from the LabelMe natural image dataset.
La différence entre les genres dans le processus d'adoption d'un logiciel de dessin à partir du modèle de l'acceptabilité des nouvelles technologies (TAM)

Ce memoire porte sur les differences entre les genres sur l'adoption des nouvelles technologies en utilisant le modele TAM (technology acceptance model), nous analysons ces differentes variables et le genre. De plus, nous avons redefini le modele du TAM, en y integrant certaines variables supplementaires que nous avons trouve dans la litterature traitant du TAM et de ces variantes. Les variables testees sont l'auto-efﬁcacite, l'expertise informatique, l'anxiete informatique, la perception de facilite d'utilisation, la perception d'utilite et l'intention future d'utilisation. Nous avons utilise un questionnaire en ligne et avons fait passer un tutoriel sur un logiciel de dessin. En effectuant une serie de test statistique, nous pouvons observer que la difference entre les femmes et les hommes n'est pas significative sur toutes les variables, et que l'interaction entre les differentes variables peut fortement interagir sur les differences de genre.
The Decay of Accreting Triple Systems as Brown Dwarf Formation Scenario

We investigate the dynamical decay of nonhierarchical accreting triple systems and its implications on the ejection model as a brown dwarf formation scenario. A modified chain-regularization scheme is used to integrate the equations of motion that also allows for mass changes over time as well as for momentum transfer from the accreted gas mass onto the bodies. We integrate an ensemble of triple systems within a certain volume with different accretion rates, assuming several prescriptions of how momentum is transferred onto the bodies. We follow their evolution until the systems have decayed. We analyze the end states and decay times of these systems and determine the fraction of brown dwarfs formed and their escape speeds, as well as the semimajor axis distribution of the formed brown dwarf binaries. We find that the formation probability of brown dwarfs depends strongly on the assumed momentum transfer, which is related to the motion of the gas. Because of ongoing accretion and consequent shrinkage of the systems, the median escape velocity is increased by a factor of 2, and the binary separations are decreased by a factor of 5 compared with nonaccreting systems. Furthermore, the obtained semimajor axis distribution drops off sharply to either side of the median, which is also supported by observations. We conclude that accretion and momentum transfer of accreted gas during the dynamical decay of triple systems is able to produce the observed distribution of close binary brown dwarfs, making the ejection model a viable option as brown dwarf formation scenario.
An uncoded BER comparison between DFE-SCCP and OFDM using a convex analysis framework

This article aims to establish a theoretical performance comparison between the Single Carrier with Cyclic Prefix (SCCP) equalized with a Decision Feedback Equalizer (DFE) and the Orthogonal Frequency Division Multiplexing (OFDM) systems. We consider an uncoded scenario and we derive analytical relations between these systems's bit error rate (BER). The comparison is accomplished for different modulation schemes.
The retrospective impact of relational victimization and attachment quality on the psychological and social functioning of college students

DISSERTATION: THE RETROSPECTIVE IMPACT OF RELATIONAL VICTIMIZATION AND ATTACHMENT QUALITY ON THE PSYCHOLOGICAL AND SOCIAL FUNCTIONING OF COLLEGE STUDENTS STUDENT: Jamie L. Goodwin DEGREE: Doctor of Philosophy COLLEGE: Teachers College PAGES: 174 Although growing evidence suggests that relational victimization is harmful to children as it occurs and shortly after, less is known about the potential long-term effects. The present study develops and validates a retrospective measure of childhood relational victimization experiences. A model is tested of the relations between childhood relational victimization experiences and early parental attachment quality on early adult psychological and social adjustment factors such as peer attachment quality, loneliness, and social anxiety, as mediated by rejection sensitivity. It has been proposed that early parental attachment quality, mediated by rejection sensitivity, may largely impact adult functioning (Downey, Khouri, & Feldman, 1997), but childhood relational victimization may also affect this psychosocial functioning. The Retrospective Relational Victimization Questionnaire (RRVQ) was developed and validated for this study to measure past relational victimization experiences. The primary study used structural equation modeling to assess a primary model of how both childhood parental attachment quality and relational victimization contribute to the experience of rejection sensitivity and in turn affects early adult functioning. A comparison is made with an alternative model which included only early parental attachment as a predictor of early adult adjustment. The RRVQ was found to be a reliable and valid measure of college students’ retrospectively recalled childhood relational victimization experiences. Neither the primary nor the alternative model was found to be well-fitting; however, additional exploratory results suggest that both early parental attachment and relational victimization experiences are significantly associated with current rejection sensitivity, while early relational victimization is somewhat more associated with current adult peer attachment, loneliness, and social anxiety than is early parental attachment. Educational, clinical, and research implications are
Altered Spontaneous Activity in Anisometropic Amblyopia Subjects: Revealed by Resting-State fMRI

Amblyopia, also known as lazy eye, usually occurs during early childhood and results in poor or blurred vision. Recent neuroimaging studies have found cortical structural/functional abnormalities in amblyopia. However, until now, it was still not known whether the spontaneous activity of the brain changes in amblyopia subjects. In the present study, regional homogeneity (ReHo), a measure of the homogeneity of functional magnetic resonance imaging signals, was used for the first time to investigate changes in resting-state local spontaneous brain activity in individuals with anisometropic amblyopia. Compared with age- and gender-matched subjects with normal vision, the anisometropic amblyopia subjects showed decreased ReHo of spontaneous brain activity in the right precuneus, the left medial prefrontal cortex, the left inferior frontal gyrus, and the left cerebellum, and increased ReHo of spontaneous brain activity was found in the bilateral conjunction area of the postcentral and precentral gyri, the left paracentral lobule, the left superior temporal gyrus, the left fusiform gyrus, the conjunction area of the right insula, putamen and the right middle occipital gyrus. The observed decreases in ReHo may reflect decreased visuo-motor processing ability, and the increases in ReHo in the somatosensory cortices, the motor areas and the auditory area may indicate compensatory plasticity in amblyopia.
Diagnosing Dementia in the Clinical Setting: Can Amyloid PET Provide Additional Value Over Cerebrospinal Fluid?

Cerebrospinal fluid (CSF) measures of amyloid and tau are the first-line Alzheimer’s disease biomarkers in many clinical centers. We assessed if and when the addition of amyloid PET following CSF measurements provides added diagnostic value. Twenty patients from a cognitive clinic, who had undergone detailed assessment including CSF measures, went on to have amyloid PET. The treating neurologist’s working diagnosis, and degree of diagnostic certainty, was assessed both before and after the PET. Amyloid PET changed the diagnosis in 7/20 cases. Amyloid PET can provide added diagnostic value, particularly in young-onset, atypical dementias, where CSF results are borderline and diagnostic uncertainty remains.
New Developments in the Classification, Pathogenesis, Risk Factors, Natural History, and Treatment of Branch Retinal Vein Occlusion

For years, branch retinal vein occlusion is still a controversial disease in many aspects. An increasing amount of data is available regarding classification, pathogenesis, risk factors, natural history, and therapy of branch retinal vein occlusion. Some of the conclusions may even change our impression of branch retinal vein occlusion. It will be beneficial for our doctors to get a deeper understanding of this disease and improve the treatment skills. The aims of this review is to collect the information above and report new ideas especially from the past a few years.
Nonparametric Bayesian Dereverberation of Power Spectrograms Based on Infinite-Order Autoregressive Processes

This paper describes a monaural audio dereverberation method that operates in the power spectrogram domain. The method is robust to different kinds of source signals such as speech or music. Moreover, it requires little manual intervention, including the complexity of room acoustics. The method is based on a non-conjugate Bayesian model of the power spectrogram. It extends the idea of multi-channel linear prediction to the power spectrogram domain, and formulates a model of reverberation as a non-negative, infinite-order autoregressive process. To this end, the power spectrogram is interpreted as a histogram count data, which allows a nonparametric Bayesian model to be used as the prior for the autoregressive process, allowing the effective number of active components to grow, without bound, with the complexity of data. In order to determine the marginal posterior distribution, a convergent algorithm, inspired by the variational Bayes method, is formulated. It employs the minorization-maximization technique to arrive at an iterative, convergent algorithm that approximates the marginal posterior distribution. Both objective and subjective evaluations show advantage over other methods based on the power spectrum. We also apply the method to a music information retrieval task and demonstrate its effectiveness.
Subtherapeutic Posaconazole Exposure and Treatment Outcome in Patients With Invasive Fungal Disease

Background: Posaconazole exposure seems to be subtherapeutic in some patients with invasive fungal disease. Due to the pharmacokinetic variability of posaconazole, therapeutic drug monitoring may help to optimize the efficacy of this antifungal drug. Methods: A retrospective study of patients treated with posaconazole from January 2008 to April 2014 and for whom posaconazole serum concentrations were available was conducted. Risk factors for underexposure of posaconazole were detected, and the relationship between posaconazole exposure and treatment outcome according to the European Organization for Research and Treatment of Cancer (EORTC) criteria was assessed. Results: Seventy patients met the inclusion criteria, 45 patients received posaconazole as treatment, and 25 patients received posaconazole as a prophylactic. Posaconazole serum trough concentrations were <1.25 mg/L in 44.4% of patients receiving treatment and <0.7 mg/L in 40.0% of patients receiving prophylactic posaconazole. Multiple linear regression analysis showed a significant, independent, and negative association of the posaconazole serum trough concentration with a lack of enteral nutrition (P < 0.001), vomiting (P = 0.035), the use of a proton pump inhibitor or H2-receptor antagonist (P < 0.001), a liquid diet (P = 0.002), concomitant chemotherapy (P = 0.004), and a posaconazole dose frequency of 2 times daily (P = 0.015). A higher posaconazole concentration was associated with a better treatment outcome [odds ratio = 22.22 (95% confidence interval, 3.40–145.33); P = 0.001]. Conclusions: Posaconazole exposure is insufficient in more than 40% of patients at risk of or with invasive fungal disease, and posaconazole exposure is positively correlated with a successful treatment outcome. Therapeutic drug monitoring of posaconazole can detect underexposure and can be helpful in treatment optimization.
Impact of OCR Errors on the Use of Digital Libraries: Towards a Better Access to Information

Digital collections are increasingly used for a variety of purposes. In Europe only, we can conservatively estimate that tens of thousands of users consult digital libraries daily. The usages are often motivated by qualitative and quantitative research. However, caution must be advised as most digitized documents are indexed through their OCRed version, which is far from perfect, especially for ancient documents. In this paper, we aim to estimate the impact of OCR errors on the use of a major online platform: The Gallica digital library from the National Library of France. It accounts for more than 100M OCRed documents and receives 80M search queries every year. In this context, we introduce two main contributions. First, an original corpus of OCRed documents composed of 12M characters along with the corresponding gold standard is presented and provided, with an equal share of English- and French-written documents. Next, statistics on OCR errors have been computed thanks to a novel alignment method introduced in this paper. Making use of all the user queries submitted to the Gallica portal over 4 months, we take advantage of our error model to propose an indicator for predicting the relative risk that queried terms mismatch targeted resources due to OCR errors, underlining the critical extent to which OCR quality impacts on digital library access.
Design of low phase noise K-band Voltage-Controlled Oscillator using 180 nm CMOS and integrated passive device technologies

This paper presents a low power and low phase noise K-band VCO using 180 nm CMOS and integrated passive device (IPD) technologies. The cross-coupling circuit in this design is composed of P-type MOSs instead of N-type. Employing PMOS results in lower flicker noise but reduces the negative transconductance (-gm). Since the IPD inductor has low parasitic resistance, the -gm generated using PMOSs can fulfill the oscillation condition for the A>band VCO. Moreover, the high-Q IPD inductor is beneficial to phase noise. The flip-chip technique is applied to assemble the CMOS and IPD structures. The oscillation frequency is from 22.6 GHz to 24.5 GHz and the minimum phase noise is -111.4 dBc/Hz at 1 MHz offset. The DC power consumption is as low as 3.4 mW from a supply voltage of 1V.
Systemic lupus erythematosus: molecular cloning and analysis of 22 individual recombinant monoclonal kappa light chains specifically hydrolyzing human myelin basic protein

Antibodies hydrolyzing myelin basic protein (MBP) can play an important role in the pathogenesis of multiple sclerosis (MS) and systemic lupus erythematosus (SLE). An immunoglobulin light chain phagemid library derived from peripheral blood lymphocytes of patients with SLE was used. Small pools of phage particles displaying light chains with different affinities for MBP were isolated by affinity chromatography on MBP‐Sepharose, and the fraction eluted with 0.5 M NaCl was used for preparation of individual monoclonal light chains (MLChs, 26–27 kDa). Seventy‐two of 440 individual colonies were randomly chosen, expressed in Escherichia coli in a soluble form, and MLChs were purified by metal chelating chromatography. Twenty‐two of 72 MLChs have high affinity and efficiently hydrolyze only MBP (not other control proteins) demonstrating various pH optima in a 5.7–9.0 range and different substrate specificity in the hydrolysis of four different MBP oligopeptides. Four MLChs demonstrated serine protease‐like and three thiol protease‐like activities, while 11 MLChs were metalloproteases. The activity of three MLChs was inhibited by both phenylmethylsulfonyl fluoride (PMSF) and Ethylenediaminetetraacetic acid (EDTA), two other by EDTA and iodoacetamide, and one by PMSF, EDTA, and iodoacetamide. The ratio of relative activity in the presence of Ca2+, Mg2+, Mn2+, Ni2+, Zn2+, Cu2+, and Co2+ was individual for each of 22 MLCh preparations. It is the first examples of human MLChs, which probably can possess two or even three different proteolytic activities. These observations suggest an extreme diversity of anti‐MBP abzymes in SLE patients. The immune systems of individual SLE patients can generate a variety of anti‐MBP abzymes, which can attack MBP of myelin‐proteolipid sheath of axons and play an important role in MS and SLE pathogenesis. Copyright © 2015 John Wiley & Sons, Ltd.