Miracle-dz/UniFAR-FTUs huggingface dataset:
Lentivirus-mediated RNA interference of tripartite motif 68 inhibits the proliferation of colorectal cancer cell lines SW1116 and HCT116 in vitro

Colorectal cancer is one of the most common types of cancer worldwide. Previous studies have revealed that certain members of tripartite motif (TRIM) proteins are involved in carcin ogenesis regulation, but little is known about the function of TRIM68 in human colorectal cancer. To investigate the role of TRIM68 in colorectal cancer SW1116 and HCT116 cell lines, the present study conducted lentivirus-mediated knockdown against TRIM68 and demonstrated that depletion of TRIM68 notably inhibits colorectal cancer cell proliferation and colony formation ability. Cell cycle arrest in the G0/G1 phase and cycle accumulation in sub-G1 phase provided evidence that TRIM68 may participate in the regulation of colorectal cancer tumorigenesis. The results revealed the significant role of TRIM68 in regulating colorectal cancer cell mitosis and indicated that TRIM68 may be a promising therapeutic target.
An analytic solution to the Busemann-Petty problem on sections of convex bodies

We derive a formula connecting the derivatives of parallel section functions of an origin-symmetric star body in R n with the Fourier transform of powers of the radial function of the body. A parallel section function (or (ni 1)dimensional X-ray) gives the ((ni 1)-dimensional) volumes of all hyperplane sections of the body orthogonal to a given direction. This formula provides a new characterization of intersection bodies in R n and leads to a unifled analytic solution to the Busemann-Petty problem: Suppose that K and L are two origin-symmetric convex bodies inR n such that the ((ni 1)-dimensional) volume of each central hyperplane section of K is smaller than the volume of the corresponding section of L; is the (n-dimensional) volume of K smaller than the volume of L? In conjunction with earlier established connections between the Busemann-Petty problem, intersection bodies, and positive deflnite distributions, our formula shows that the answer to the problem depends on the behavior of the (ni 2)-nd derivative of the parallel section functions. The a‐rmative answer to the Busemann-Petty problem for n• 4 and the negative answer for n‚ 5 now follow from the fact that convexity controls the second derivatives, but does not control the derivatives of higher orders.
Randomized Controlled Trial of Early Rehabilitation After Intracerebral Hemorrhage Stroke: Difference in Outcomes Within 6 Months of Stroke

Background and Purpose— Mechanisms, acute management, and outcomes for patients who experience intracerebral hemorrhage may differ from patients with ischemic stroke. Studies of very early rehabilitation have been mainly undertaken in patients with ischemic stroke, and it is unknown if benefits apply to those with intracerebral hemorrhage. We hypothesized that early rehabilitation, within 48 hours of stroke, would improve survival and functional outcomes in patients with intracerebral hemorrhage. Methods— This was a multicenter, randomized controlled study, with blinded assessment of outcome at 3 and 6 months. Eligible patients were randomized to receive standard care or standard care plus early rehabilitation. Primary outcome includes survival. Secondary outcomes includes health-related quality of life using the 36-item Short Form Questionnaire, function measured with the modified Barthel Index, and anxiety measured with the Zung Self-Rated Anxiety Scale. Results— Two hundred forty-three of 326 patients were randomized (mean age, 59 years; 56% men). At 6 months, patients receiving standard care were more likely to have died (adjusted hazard ratio, 4.44; 95% confidence interval [CI], 1.24–15.87); for morbidity outcomes, a 6-point difference in the Physical Component Summary score of the 36-item Short Form Questionnaire (95% CI, 4.2–8.7), a 7-point difference for the Mental Component Summary score (95% CI, 4.5–9.5), a 13-point difference in Modified Barthel Index scores (95% CI, 6.8–18.3), and a 6-point difference in Self-Rating Anxiety Scale scores (95% CI, 4.4–8.3) was reported in favor of the intervention groups. Conclusions— For the first time, we have shown that commencing rehabilitation within 48 hours of intracerebral hemorrhage improves survival and functional outcomes at 6 months after stroke in hospitalized patients in China. Clinical Trial Registration— URL: http://www.chictr. org/en. Unique identifier: ChiCTR-TRC-13004039.
UvA-DARE ( Digital Academic Repository ) Base J originally found in kinetoplastida is also a minor constituent of nuclear DNA of Euglena

We have analyzed DNA of Euglena gracilis for the presence of the unusual minor base β-D-glucosylhydroxymethyluracil or J, thus far only found in kinetoplastid flagellates and in Diplonema. Using antibodies specific for J and post-labeling of DNA digests followed by two-dimensional thin-layer chromatography of labeled nucleotides, we show that ~0.2 mole percent of Euglena DNA consists of J, an amount similar to that found in DNA of Trypanosoma brucei. By staining permeabilized Euglena cells with anti-J antibodies, we show that J is rather uniformly distributed in the Euglena nucleus, and does not co-localize to a substantial extent with (GGGTTA)n repeats, the putative telomeric repeats of Euglena. Hence, most of J in Euglena appears to be non-telomeric. Our results add to the existing evidence for a close phylogenetic relation between kinetoplastids and euglenids.
Formant Vowel Structure Tracking by Goertzel Algorithm

Formant frequencies structure gives a good view to determine linguistic as well as non-linguistic speech meaning and it represents a significant parameter within the synthesis and speech recognition procedure. In fact formants are groups of harmonics enhanced by the vocal tract resonance. There is a resonance i.e. the enhancement of spectral energy in speech signal spectrum at formant frequencies. Formant vowel /a/ structure tracking by Goertzel algorithm is presented in this paper.
Self-Expression Through Brand and Consumption Choices: Examining Cross-Cultural Differences

Author(s): Takashima, Mirei | Advisor(s): Sood, Sanjay | Abstract: In this dissertation, I investigated how the brand and consumption choices across cultures vary in meaning. In particular, I examined how self-expression through choice varies between the Western and East Asian cultural contexts due to the difference in how the self is viewed. Specifically, Westerners express self-consistency because they view themselves as independent and consistent regardless of the context. In contrast, East Asians express through self-improvement efforts because they view themselves as interdependent and thus have an obligation to invest effort into becoming a model social being through self-improvement. The topic of self-expression is particularly relevant and intriguing in the East Asian cultural context, as the most common portrayal of East Asian individuals emphasizes the conformist, socially obligated nature of their being. Hence, in this current research, I explored the meaning of East Asian individuality and selfhood in the context of brand and consumption choices. In Experiments 1 through 3, the results provided converging evidence that Western individuals have a higher self-brand connection when compared to East Asian individuals, and therefore are more loyal to the brands that they favor. In contrast, East Asians are less loyal to brands because of their higher interest in non-brand attributes. In Experiments 4 and 5, I focused on the luxury brands category to further explore the cross-cultural difference in brand and consumption choices. The results confirmed that East Asians, when compared to Westerners, have a higher appreciation for distinctive but relatively intangible features involving craftsmanship and heritage. In Experiment 5, I explored the topic of East Asian self-expression more directly. The results confirmed my hypothesis that East Asians self-express through their consumption choices by selecting the more unique, less popular option over the standard, more popular option—but only when it is socially appropriate to do so. The findings from this research provide new insight into the cross-cultural differences in how people self-express through their brand and consumption choices as a result of their varying self-concepts. Furthermore, the findings also shed additional light on the concept of East Asian self-expression, and confirm that one does not have to subscribe to the principles of individualism to be an individual.
Sense Generation: A "Quasi-Classical" Approach to Concepts and Concept Combination

This article presents a detailed formal approach to concepts and concept combination. Sense generation is a competence-level theory that attempts to respect constraints from the various cognitive sciences, and postulates “quasi-classical” conceptual structures where attributes receive only one value (but are defeasible and so do not represent necessary and sufficient conditions on category membership) and where classification is binary (but explicitly context-sensitive). It is also argued that any general theory of concepts must account for “privative” combinations (e.g., stone lion, fake gun, apparent friend) as extreme test-cases of representational and classificatory flexibility. The approach presented therefore provides a treatment of these combinations. The approach differentiates between the “lexical concept” (the stable information represented in a mental lexicon) which acts as a base from which the various “senses” (flexible contents associated with words and phrases in context, and used in classification) are “generated. ” Generation allows nonmonotonicity, so that in different circumstances, different attributes may be defeated or modified. Classification is treated as relative to the perspective adopted, so that a classification acceptable from one perspective may be unacceptable from another, without contradiction. The result is a view that assumes bottom-up priority in concept combination, where the range of senses generated by bottom-up rules of combination is tempered by pragmatic-communicative constraints on classification. An account of the representational and classification behavior of privative combinations is outlined, and the article concludes with a discussion of some of the implications of the approach.
Learning soft task priorities for control of redundant robots

One of the key problems in planning and control of redundant robots is the fast generation of controls when multiple tasks and constraints need to be satisfied. In the literature, this problem is classically solved by multi-task prioritized approaches, where the priority of each task is determined by a weight function, describing the task strict/soft priority. In this paper, we propose to leverage machine learning techniques to learn the temporal profiles of the task priorities, represented as parametrized weight functions: we automatically determine their parameters through a stochastic optimization procedure. We show the effectiveness of the proposed method on a simulated 7 DOF Kuka LWR and both a simulated and a real Kinova Jaco arm. We compare the performance of our approach to a state-of-the-art method based on soft task prioritization, where the task weights are typically hand-tuned.
Evolutionary Robotics at Sussex

We give an overview of evolutionary robotics research at Sussex. We explain and justify our distinctive approaches to (artiicial) evolution, and to the nature of robot control systems that are evolved. We illustrate by presenting results from research with evolved controllers for autonomous mobile robots; simulated robots, coevolved animats, real robots with software controllers or with a controller directly evolved in hardware. WHY EVOLUTIONARY ROBOTICS? When designing a control system for a robot, there are at least three major problems: It is not clear how a robot control system should be decomposed. Interactions between separate subsystems are not limited to directly visible connecting links, but also include interactions mediated via the environment. As system complexity grows, the number of potential interactions between sub-parts of the system grows exponentially. Classical approaches to robotics have often assumed a primary decomposition into Perception, Planning and Action modules. Many people now see this as a basic error 2]. Brooks acknowledges the latter two problems above in his subsumption architecture approach. This advocates slow and careful building up of a robot control system layer by layer, in an approach that is explicitly claimed to be inspired by natural evolution | though each new layer of behaviour is wired in by hand design. An obvious alternative approach is to abandon hand design and explicitly use evolutionary techniques to incrementally evolve increasingly complex robot control systems. Unanticipated interactions between subsystems need not directly bother an evolutionary process where the only benchmark is the behaviour of the whole system. Other individuals and groups have taken a similar evolutionary approach, such as 1]]5]]12]; here we concentrate on an overview of work at Sussex. We start with theoretical questions of what artiicial evolutionary techniques and classes of control system are appropriate for evolutionary design. We discuss the relationship between robot simulations and reality, and the problem of evaluation within a noisy and uncertain environment. Sussex projects in this area are described, with both simulations and real robots, including hardware evolution.
Measuring the user's anonymity when disclosing personal properties

Anonymous credentials allow to selectively disclose personal properties included in the credential, while hiding the other information. For instance, a user could only disclose that he is an adult using a credential in which zip code and date of birth are included, which remain hidden for the verifier. This is a considerable improvement w.r. t. the user's anonymity. However, by disclosing too much personal properties, the user can drastically decrease his anonymity and can even become identifiable. Credentials can be shown multiple times under the same pseudonym, making usages of the same credential linkable which introduces new anonymity threats. These threats are discussed in this paper and a method is proposed whereby a user agent retrieves data in order to inform the user about his minimum level of anonymity w.r. t. a particular service provider.
Phosphorylation of the carboxy-terminal domain of histone H1: effects on secondary structure and DNA condensation

Linker histone H1 plays an important role in chromatin folding. Phosphorylation by cyclin-dependent kinases is the main post-translational modification of histone H1. We studied the effects of phosphorylation on the secondary structure of the DNA-bound H1 carboxy-terminal domain (CTD), which contains most of the phosphorylation sites of the molecule. The effects of phosphorylation on the secondary structure of the DNA-bound CTD were site-specific and depended on the number of phosphate groups. Full phosphorylation significantly increased the proportion of β-structure and decreased that of α-helix. Partial phosphorylation increased the amount of undefined structure and decreased that of α-helix without a significant increase in β-structure. Phosphorylation had a moderate effect on the affinity of the CTD for the DNA, which was proportional to the number of phosphate groups. Partial phosphorylation drastically reduced the aggregation of DNA fragments by the CTD, but full phosphorylation restored to a large extent the aggregation capacity of the unphosphorylated domain. These results support the involvement of H1 hyperphosphorylation in metaphase chromatin condensation and of H1 partial phosphorylation in interphase chromatin relaxation. More generally, our results suggest that the effects of phosphorylation are mediated by specific structural changes and are not simply a consequence of the net charge.
Depletion of T Cells by Type I Interferon: Differences between Young and Aged Mice1

Type I IFN (IFN-I or IFN-αβ) plays an important role in the innate immune response against viral infection. Here we report that a potent inducer of IFN-αβ, polyinosinic-polycytidylic acid [poly(I:C)], led to the depletion of T cells in young, but not aged mice, and that this depletion was limited to central memory, but not effector memory, T cells. Although early activation of T cells in vivo by poly(I:C), as demonstrated by CD69, was not impaired with aging, the expression of active caspase-3 was higher in young compared with aged mice. This depletion of T cells and induction of active caspase-3 in young mice and of CD69 in both young and aged mice by poly(I:C) were blocked by anti-IFN-αβ Ab. Although poly(I:C) stimulated lower circulating levels of IFN-αβ in aged mice, administration of IFN-αβ after poly(I:C) did not induce depletion of T cells in aged mice. These results indicate that IFN-αβ plays a critical role in the depletion of T cells of young mice, and further suggest that the lower level of functional IFN-αβ and decreased induction of active caspase-3 in T cells of aged mice after poly(I:C) may be responsible for the increased resistance of T cells of aged mice to depletion.
GRGEC: computer algebra system for applications to gravity theory

We present a general outline of the specialized computer algebra system GRCEC intended for symbolic calculations in the field of the gravitation theory, the classical field theory on a curved background, and the adjacent methods belonging to the differential geometry. The distinctive features of the GRCEC input language are exhibited and the noteworthy elements of the system design are discussed.
Crossing disciplinary lines: reconciling social and genomic perspectives on the histories and legacies of the transatlantic trade in enslaved Africans

Over the past two decades, advances in the field of genomics have presented new opportunities to shed light upon the origins of enslaved Africans and their contemporary descendants. While this possibility has caused enthusiasm among members of the public, it has provoked contention within the academic sphere. This paper represents an attempt to reconcile these opposing disciplinary divisions, by examining, explaining, and discussing the processes involved in the production of genetic “ancestry” estimates, in order to moderate the aura of absolute “truth” that is often associated with such techniques. Our discussion focuses on two case studies – the academic use of ancient DNA analyses to estimate the geographic origins of historically enslaved individuals, and the commercialization of DNA “ancestry” testing techniques aimed at African-American roots-seekers – and draws upon recent ethnographic data relating to the experiences of test creators and test-takers, in order to contribute to this debate.
Relating to the Other in Psychosis: an Interpretative Phenomenological Analysis

2 Acknowledgements I would like to thank all the people involved in helping me to complete this project. In particular, I am hugely indebted to the seven participants who were brave and generous enough to share both their time and their stories. It was a privilege. A big thank you to my supervisors John, for all the inspiration and expertise, and Pieter, for his guidance and endless patience. I am hugely grateful to both of you for the great supervision and support over the last couple of years. I have been very lucky to have such great friends, especially Yvonne for all the care and for being such an inspiration to me and also Cohort 11 for the good times, especially Aisling for always being willing to listen, encourage and answer my constant questions. I am so grateful to my family for being a huge source of support for me, especially my Mam for all the love and unwavering belief in me and my Manolis, for his love, encouragement and being the constant throughout, when things were good and bad. Thank you.
Drift compensating effect during hot-carrier degradation of 130nm technology dual gate oxide P-channel transistors

We present hot-carrier measurement results on a 130nm dual gate oxide MOS transistor technology node which is used for automotive and analog applications with a nominal voltage of 3.3V. Transistors of several geometries have been stressed at various gate and drain voltage combinations at room and elevated (125°C) temperatures. The results show two main degradation effects with one drift type (DIsub, max) close to the traditional hot-carrier degradation worst-case condition and another (DΨ, max) for Vds = Vgs. Both effects compensate the drift after a specific stress time. The drifts and their compensation are clearly observable by analyzing the change of the substrate current characteristics over stress time. In the literature several mechanisms for hot-carrier degradation have been reported. The first effect is related to the bond dissociation caused by a single high energetic carrier while the second one is due to the multiple vibrational excitation of the bond by several “colder” carriers. The results underline the importance of that approach and provide a benchmark for device degradation simulations due to the good separability of the observed effects. Long term stress data show that even for low Vgs the drift type DIsub, max will be compensated by DΨ, max.
A dynamic adjustment algorithm research of sentiment word weight based on context

The emotion tendency of sentiment word is divided into two types: static emotion tendency and dynamic emotion tendency. Basic semantic lexicon is static emotion tendency, in the real context, but it is different between static emotion tendency and dynamic emotion tendency. The paper proposes a method based on degree lexicon, negative lexicon and dependence relationship of sentence elements. The experimental results show dynamic emotion tendency even more reflects text emotion tendency and get best performance in text sentiment classification.
Data management and preliminary data analysis in the pilot phase of the HUPO Plasma Proteome Project

The pilot phase of the HUPO Plasma Proteome Project (PPP) is an international collaboration to catalog the protein composition of human blood plasma and serum by analyzing standardized aliquots of reference serum and plasma specimens using a variety of experimental techniques. Data management for this project included collection, integration, analysis, and dissemination of findings from participating organizations world‐wide. Accomplishing this task required a communication and coordination infrastructure specific enough to support meaningful integration of results from all participants, but flexible enough to react to changing requirements and new insights gained during the course of the project and to allow participants with varying informatics capabilities to contribute. Challenges included integrating heterogeneous data, reducing redundant information to minimal identification sets, and data annotation. Our data integration workflow assembles a minimal and representative set of protein identifications, which account for the contributed data. It accommodates incomplete concordance of results from different laboratories, ambiguity and redundancy in contributed identifications, and redundancy in the protein sequence databases. Recommendations of the PPP for future large‐scale proteomics endeavors are described.