Miracle-dz/UniFAR-FTUs huggingface dataset:
Deguelin inhibits epithelial‐to‐mesenchymal transition and metastasis of human non‐small cell lung cancer cells by regulating NIMA‐related kinase 2

Non‐small cell lung cancer is a lethal malignancy with a high mortality rate. Deguelin displays an anti‐tumor effect and inhibits metastasis in various cancers. The aberrant expression of NIMA‐related kinase 2 (NEK2) indicates poor prognosis and induces epithelial‐to‐mesenchymal transition (EMT) and metastasis processes. However, the underlying mechanism between deguelin and NEK2 has remained elusive.
A framework for investigating the performance of sum aggregations over encrypted data warehouses

Homomorphic encryption (HE) allows the execution of queries over encrypted data without requiring decryption. However, we found a lack of studies for investigating the use of HE in data warehouse (DW). In this article, we propose a framework that defines how a HE scheme can be used to encrypt numeric measures of a DW, and how sum aggregation functions of analytic queries are processed over encrypted DWs created according to our framework. Also, we propose a system architecture for safely processing encrypted DWs and describe performance tests that investigated the impact of HE schemes on the performance of analytic queries executed over encrypted DWs. Results indicated that HE generated performance gains of up to 47.46% w.r. t. an encryption scheme that was unable of computing aggregates over encrypted data. Also, results showed that the use of HE caused overheads of up to 16.55% on the computation of aggregates w.r. t. an unencrypted DW.
From ‘automation’ to ‘autonomy’: the importance of trust repair in human–machine interaction

Abstract Modern interactions with technology are increasingly moving away from simple human use of computers as tools to the establishment of human relationships with autonomous entities that carry out actions on our behalf. In a recent commentary, Peter Hancock issued a stark warning to the field of human factors that attention must be focused on the appropriate design of a new class of technology: highly autonomous systems. In this article, we heed the warning and propose a human-centred approach directly aimed at ensuring that future human–autonomy interactions remain focused on the user’s needs and preferences. By adapting literature from industrial psychology, we propose a framework to infuse a unique human-like ability, building and actively repairing trust, into autonomous systems. We conclude by proposing a model to guide the design of future autonomy and a research agenda to explore current challenges in repairing trust between humans and autonomous systems. Practitioner Summary: This paper is a call to practitioners to re-cast our connection to technology as akin to a relationship between two humans rather than between a human and their tools. To that end, designing autonomy with trust repair abilities will ensure future technology maintains and repairs relationships with their human partners.
Nebulization of Nanocolloidal Suspensions for the Growth of Nanocomposite Coatings in Dielectric Barrier Discharges

The nebulization of colloidal suspensions is analyzed by dynamic light scattering, scanning, and transmission electron microscopies. While primary agglomeration can be important for many nanoparticle-solvent couples, our results indicate that for TiO2 nanoparticles dispersed in water, secondary agglomeration also occurs during nebulization. When nebulization is realized immediately after sustaining a plane-to-plane dielectric barrier discharge at atmospheric pressure, the collection efficiency of TiO2 nanoparticles increases due to the presence of a remanent electric field between the two electrodes. Finally, these findings are used to deposit SiO2–TiO2 nanocomposite thin films by alternating the deposition of dense silica-like layers in a Townsend discharge and the collection of TiO2 nanoparticles through nebulization of the nanocolloidal suspension.
Development and Validation of A Stability Indicating Liquid Chromatographic Method for Simultaneous Estimation of Arterolane Maleate and Piperaquine Phosphate in Combined Dosage Form

A novel stability indicating isocratic, reversed phase-liquid-chromatographic method has been developed for the simultaneous quantitative determination of Arterolane maleate And Piperaquine phosphate in combined-dosage form. A thermo hypersil BDS C18 (250*4.6*5µ) column with mobile phase containing water pH 2.8 adjusted with ortho phosphoric acid: methanol in the ratio of (60: 40, v/v) was used. The flow rate was 1.0 mL/min, column temperature was 30°C and effluents were monitored at 241 nm. The retention times of Arterolane Maleate and Piperaquine Phosphate were 1.864min and 3.047min, respectively. Correlation co-efficient for Arterolane Maleate and Piperaquine Phosphate was found to be 0.99 and 0.99, respectively. The proposed method was validated with respect to linearity, accuracy, precision, specificity, and robustness. Recovery of Arterolane Maleate and Piperaquine Phosphate in formulations was found to be in the range of 97-103% and 97103% respectively confirms the non-interferences of the excipients in the formulation. Arterolane Maleate and Piperaquine Phosphate were exposed to stress conditions like acidic hydrolysis, basic hydrolysis, oxidative, photolytic, humidity and thermal conditions. Due to its simplicity, rapidness and high precision, the method was successfully applied to the estimation of Arterolane Maleate and Piperaquine Phosphate in combined dosage form.
Glucagon-like peptide-1: a potent regulator of food intake in humans

Background/Aims Studies in animals suggest a physiological role for glucagon-like peptide-1-(7–36)-amide (GLP-1) in regulating satiety. The role of GLP-1 in regulating food intake in man has, however, not been investigated. Subjects—Sixteen healthy male subjects were examined in a double blind placebo controlled fashion. Methods The effect of graded intravenous doses (0, 0.375, 0.75, and 1.5 pmol/kg/min) of synthetic human GLP-1 on food intake and feelings of hunger and satiety was tested in healthy volunteers. Results Graded GLP-1 infusions resulted in a dose dependent reduction in food intake (maximal inhibition 35%, p<0.001 vcontrol) and a similar reduction in calorie intake (32%; p<0.001). Fluid ingestion was also reduced by GLP-1 (18% reduction, p<0.01). No overt side effects were produced by GLP-1, but subjects experienced less hunger and early fullness in the period before a meal during GLP-1 infusion at the highest dose (p<0.05). Conclusions Intravenous infusions of GLP-1 decrease spontaneous food intake even at physiological plasma concentrations, implying an important role for GLP-1 in the regulation of the early satiety response in humans.
How Habitat Edges Change Species Interactions

Traditionally, ecologists interested in habitat edges have focused on edge‐related gradients in patterns of species richness or abiotic variables. Here, however, we take a different perspective, attempting to synthesize recent empirical results concerning the effects of habitat edges on population dynamics with contemporary theoretical developments to outline the ways in which species interactions, and the dynamics of the communities in which they are embedded, can be changed by habitat edges. We find a striking convergence between empirical notions of a patch's core area and analytical results from partial differential equation models. A review of both empirical and theoretical studies suggests four general classes of mechanisms through which habitat edges can have similar impacts on dissimilar types of species interactions. Specifically, we focus on edges' roles as dispersal barriers or filters, edges' influences on mortality, edges' involvement in spatial subsidies (in which dispersers' intrapatch impacts are maintained by their activities in other habitats), and edges' roles as generators of novel interactions. For each class of edge‐mediated effects, we provide examples of how one can use spatial modeling to address the relevant questions on these topics, which together form a key link between community dynamics and landscape structure.
Enhanced optoelectronic property of ZnO under negative pressure condition: a first-principles study

In contrary to high pressure phases of ZnO, recent experimental evidence suggests that β-BeO type lattice modification of ZnO may be realised under negative pressure condition generated by lattice mismatch or by applying strain. The first-principles calculation based on density functional theory (DFT) is employed to investigate the negative pressure phase β-BeO, and the outcomes of the structural, electronic, and optical properties of this phase are compared with the ambient condition wurtzite B4 phase of ZnO. Our phase transition study shows that the B4 phase transforms into the β-BeO phase around negative pressure of −4 GPa and this new phase retains its structural stability even under more negative pressure. Further, the volume of the β-BeO phase increases resulting in a low-density phase with more anisotropic nature and distorted tetrahedral around Zn (or O) atoms along with (2 + 2) coordination as compared to B4 phase. The electronic structure of low-density β-BeO phase changes significantly, however, the band gaps of both the phases are almost same. The change in electronic structure of β-BeO phase turns into a significant blue shift in lower energy region of optical spectra. Moreover, the smaller effective mass values of charge carriers in β-BeO phase compared to B4 phase indicate high mobilities of charge carriers to attain enhanced conductivity. Further, the analysis of optical properties of β-BeO phase indicate the smaller values of reflectivity and absorption coefficients and consequently an enhanced transmittance value of 90% in visible region of optical spectra. The lower effective masses of charge carriers and enhancement in transmittance makes the low density negative pressure β-BeO phase suitable for achieving enhanced optoelectronic property of ZnO.
Plants under Stress: Involvement of Auxin and Cytokinin

Plant growth and development are critically influenced by unpredictable abiotic factors. To survive fluctuating changes in their environments, plants have had to develop robust adaptive mechanisms. The dynamic and complementary actions of the auxin and cytokinin pathways regulate a plethora of developmental processes, and their ability to crosstalk makes them ideal candidates for mediating stress-adaptation responses. Other crucial signaling molecules responsible for the tremendous plasticity observed in plant morphology and in response to abiotic stress are reactive oxygen species (ROS). Proper temporal and spatial distribution of ROS and hormone gradients is crucial for plant survival in response to unfavorable environments. In this regard, the convergence of ROS with phytohormone pathways acts as an integrator of external and developmental signals into systemic responses organized to adapt plants to their environments. Auxin and cytokinin signaling pathways have been studied extensively. Nevertheless, we do not yet understand the impact on plant stress tolerance of the sophisticated crosstalk between the two hormones. Here, we review current knowledge on the function of auxin and cytokinin in redirecting growth induced by abiotic stress in order to deduce their potential points of crosstalk.
The universal, collaborative and dynamic model of specialist and advanced nursing and midwifery practice: A way forward?

AIMS AND OBJECTIVES To inform and guide the development of a future model of specialist and advanced nursing and midwifery practice. BACKGROUND There is a sizable body of empirical literature supporting the unique contributions of specialist and advanced practice roles to health care. However, there is very little international evidence to inform the integration of a future model for advanced or specialist practice in the Irish healthcare system. DESIGN A qualitative study was conducted to initiate this important area of inquiry. METHODS Purposive sampling was used to generate a sample of informants (n = 15) for the interviews. Nurses and midwives working in specialist and advanced practice and participants from other areas such as legislative, regulatory, policy, medicine and education were included in the sampling frame. RESULTS Arguments for a new model of specialist and advanced practice were voiced. A number of participants proposed that flexibility within specialist and advanced practitioner career pathways was essential. Otherwise, there existed the possibility of being directed into specialised "silos," precluding movement to another area of integrated practice. Future specialist and advanced practice education programmes need to include topics such as the development of emotional and political intelligence. CONCLUSION The contribution of specialist and advanced practice roles to the health service includes providing rapid access to care, seamless patient flow across services, early discharge and lead coordinator of the patient's care trajectory. There was a recommendation of moving towards a universal model to cultivate specialist and advanced nurse and midwife practitioners. RELEVANCE TO CLINICAL PRACTICE The model design has Universal application in a range of contexts "U. " It is Collaborative in its inclusivity of all key stakeholders "C. " The model is Dynamic pertinent to accommodating movement of nurses and midwives across health continua rather than plateauing in very specialised "silos" "D. "
Engagement in Steps of Advance Health Care Planning by Homeless Veterans

Communicating health care preferences in advance, so that wishes can be honored if the person becomes unable to participate in decision-making, is especially important for vulnerable populations such as homeless veterans. Hospitals are required to inform patients of their rights to document their preferences, but completion rates for advance directives are low. Conceptualizing advance health care planning as a series of health behavior steps emphasizing communication is recommended for improving engagement in advance health care planning. The authors used program evaluation data from psychoeducational groups with 288 homeless veterans to learn about their previous experience with different steps of advance health care planning and their personal goals for future steps. Results revealed a significant discrepancy between what these veterans reported they have done and information available to health care providers in the medical record: Only 26% had an advance directive in the medical record, but 70% reported they had thought about the care they would want, and almost half reported they had talked with a trusted other or named someone to make decisions for them. The most frequent goal endorsed by veterans attending groups was discussing advance health care planning with family or trusted others and/or naming someone to be a decision maker. These findings indicate a need for improved communication and documentation of veteran preferences about emergency and end of life care. Results are also consistent with interventions tailored to varying readiness for different steps of advance health care planning.
Influence of the Plasma of Nanosecond Diffuse Discharge in Air at Atmospheric Pressure on the Electrophysical Properties of Epitaxial CdHgTe Films

In this paper the influence of the volume discharge of nanosecond duration formed in a non-uniform electric field at atmospheric pressure on samples of CdHgTe (MCT) epitaxial films of p-type conductivity is investigated. Measurements of electro-physical parameters of MCT samples after irradiation have shown that a layer exhibiting n-type conductivity is formed in the near-surface area of epitaxial films. After more than 600 pulses of influence parameters and thickness of the resulting n-layer is such that the measured field dependence of Hall coefficient corresponds to the material of n-type conductivity. The obtained results show that application of volume nanosecond discharge in air at atmospheric pressure is promising for the modification of the surface properties of epitaxial films of MCT.
Targeting Algorithm Based on ITSM

In this paper, the tactical significance map (TSM) is introduced at first, and then a novel prioritizing method based on improved TSM (ITSM) is proposed. a prioritizing model based on multi-attribute linear weighting is established; and then, through improving the tactical significance map (TSM), a novel targets prioritizing algorithm is proposed, which is extended to multi-asset attack scenario. The simulations executed in single-asset attack and multi-asset attack indicate that the proposed algorithm definitely reflects the relationship between the attributes and the priority. As a result, the proposed algorithm canadapt to the real battlefield more easily than the multi-attribute linear weighting and tactical significance map. The application scope is extended from two-dimension to three-dimension, and the assets needed to protect are extended from single asset to multi-asset. Simulation results indicate that the proposed method can adapt to the real battlefield situation.
Mechanisms of thermal adaptation and evolutionary potential of conspecific populations to changing environments

Heterogeneous and ever‐changing thermal environments drive the evolution of populations and species, especially when extreme conditions increase selection pressure for traits influencing fitness. However, projections of biological diversity under scenarios of climate change rarely consider evolutionary adaptive potential of natural species. In this study, we tested for mechanistic evidence of evolutionary thermal adaptation among ecologically divergent redband trout populations (Oncorhynchus mykiss gairdneri) in cardiorespiratory function, cellular response and genomic variation. In a common garden environment, fish from an extreme desert climate had significantly higher critical thermal maximum (p < .05) and broader optimum thermal window for aerobic scope (>3°C) than fish from cooler montane climate. In addition, the desert population had the highest maximum heart rate during warming (20% greater than montane populations), indicating improved capacity to deliver oxygen to internal tissues. In response to acute heat stress, distinct sets of cardiac genes were induced among ecotypes, which helps to explain the differences in cardiorespiratory function. Candidate genomic markers and genes underlying these physiological adaptations were also pinpointed, such as genes involved in stress response and metabolic activity (hsp40, ldh‐b and camkk2). These markers were developed into a multivariate model that not only accurately predicted critical thermal maxima, but also evolutionary limit of thermal adaptation in these specific redband trout populations relative to the expected limit for the species. This study demonstrates mechanisms and limitations of an aquatic species to evolve under changing environments that can be incorporated into advanced models to predict ecological consequences of climate change for natural organisms.
Long-lasting and bioactive hyaluronic acid-hydroxyapatite composite hydrogels for injectable dermal fillers: Physical properties and in vivo durability

Hyaluronic acid (HAc)–hydroxyapatite (HAp) composite hydrogels were developed to improve the biostability and bioactivity of HAc for dermal filler applications. Two kinds of HAc-HAp composite fillers were generated: HAcmicroHAp and HAc-nanoHAp composites. HAc-microHAp was fabricated by mixing HAp microspheres with HAc hydrogels, and HAc-nanoHAp was made by in situ precipitation of nano-sized HAp particles in HAc hydrogels. Emphasis was placed on the effect of HAp on the durability and bioactivity of the fillers. Compared with the pure HAc filler, all of the HAc-HAp composite fillers exhibited significant improvements in volumetric maintenance based on in vivo tests owing to their reduced water content and higher degree of biointegration between the filler and surrounding tissues. HAc-HAp composite fillers also showed noticeable enhancement in dermis recovery, promoting collagen and elastic fiber formation. Based on their long-lasting durability and bioactivity, HAc-HAp composite fillers have great potential for soft tissue augmentation with multifunctionality.
Long‐term water quality data explain interpopulation variation in responsiveness to stress in sticklebacks at both wastewater effluent‐contaminated and uncontaminated sites

The magnitude of the corticosteroid response to a standardized stressor varied in proportion to the concentration of effluent in three‐spined sticklebacks (Gasterosteus aculeatus L.) captured downstream of 10 wastewater‐treatment plants (WWTPs). However, at 9 sites with no upstream WWTP input interpopulation variation in the reactivity of the stress axis occurred across a similar range to that seen for fish at impacted sites, suggesting that the factor(s) responsible for modulating stress responsiveness in sticklebacks is not unique to sites receiving WWTP effluent. Physicochemical data from a long‐term monitoring program were employed to investigate whether variation in water quality contributed to between‐site variation in stress axis reactivity. Between‐site variation in 14 water quality determinands explained between 30% and 60% of the variation in stress reactivity and fish size for sticklebacks at both WWTP–contaminated and uncontaminated sites. At uncontaminated sites the mean mass and length of sticklebacks increased with total oxidized nitrogen (N) concentration (as an indicator of anthropogenic input), whereas at WWTP–contaminated sites fish size decreased with increasing effluent concentration, suggesting that factors adversely affecting growth were present predominantly at WWTP–contaminated sites. In contrast, at both contaminated and uncontaminated sites the magnitude of the corticosteroid response to a standardized stressor increased with anthropogenic input (effluent concentration or total oxidized N, respectively), indicating that a factor or factors modulating the reactivity of the stress axis may be present at both WWTP–contaminated and uncontaminated sites. Environ Toxicol Chem 2016;35:3014–3022. © 2016 SETAC
Extraction of informative regions of a face for facial expression recognition

The aim of facial expression recognition (FER) algorithms is to extract discriminative features of a face. However, discriminative features for FER can only be obtained from the informative regions of a face. Also, each of the facial subregions have different impacts on different facial expressions. Local binary pattern (LBP) based FER techniques extract texture features from all the regions of a face, and subsequently the features are stacked sequentially. This process generates the correlated features among different expressions, and hence affects the accuracy. This research moves toward addressing these issues. The authors' approach entails extracting discriminative features from the informative regions of a face. In this view, they propose an informative region extraction model, which models the importance of facial regions based on the projection of the expressive face images onto the neural face images. However, in practical scenarios, neutral images may not be available, and therefore the authors propose to estimate a common reference image using Procrustes analysis. Subsequently, weighted-projection-based LBP feature is derived from the informative regions of the face and their associated weights. This feature extraction method reduces miss-classification among different classes of expressions. Experimental results on standard datasets show the efficacy of the proposed method.