Miracle-dz/UniFAR-FTUs huggingface dataset:
The University of Santo Tomas Hospital (USTH) 2022 Institutional Chest Pain Pathway: Approach to Diagnosis, Risk Stratification, and Management

This clinical pathway for the diagnosis and risk stratification of patients presenting with acute chest pain, including acute coronary syndromes, provides recommendations and algorithms for clinicians to diagnose, risk stratify, and manage acute chest pain in adult patients. The writing committee reviewed existing international and local guidelines. Modifications to the algorithm following face-to-face and virtual meetings resulted in expert decisions written as recommendations and presented in a flow diagram format. The USTH Chest Pain Pathway provides guidance based on current guidelines and recommendations on assessing and evaluating acute chest pain, tailored to local needs and institution-specific facilities. We recommend its use to ensure quality patient care in the hospital. Key Words: angina pectoris, acute chest pain, acute coronary syndrome, clinical decision pathway, diagnostic pathway, risk stratification, emergency care
Autonomous Shuttle Operating on Highways and Gravel Roads in Rural America: A Demonstration Study

The safe integration of Automated Driving Systems (ADS) into the nation’s on-road transportation system, particularly in rural areas, could vastly improve overall quality of life for a rapidly growing segment of the US population. This paper describes findings from the first half (i.e., three of six phases) of a demonstration project called “ADS for Rural America”. The goal of this project is to conduct a series of demonstrations that utilizes an autonomous shuttle to show how older adults (≥65 years old) could be transported from their rural homes to other locations in rural areas, as well as an urban center. This paper examines older adults’ perceptions of automation before and after riding in an autonomous shuttle and their ratings of anxiety throughout the ride as they experience particular road types and maneuvers. After riding in the shuttle, older adults expressed decreased suspicion, increased trust, and increased reliability of ADS compared to baseline. Older adults reported low levels of anxiety during the 90 min ride in the shuttle. To promote the adoption and acceptance of ADS, older adults should be exposed to this technology.
Existence of broad acoustic bandgaps in three-component composite

Experimental and theoretical studies of acoustic transmission through a two-dimensional three-component composite composed of a square array of coated cylinders embedded in an epoxy resin are presented in this paper. The coated cylinders consist of steel inner core and rubber coating, which has much smaller wave velocity and mass density than the matrix and inner material. We observed a broad bandgap in the measured power spectrum along the $\ensuremath{\Gamma}X$ propagation direction where only the noise level is measured. The two-component counterparts composed of a square array of steel cylinders embedded in an epoxy resin without rubber coating are also studied to investigate the influence of the soft coating on the properties of bandgaps. The transmission spectrum along the $\ensuremath{\Gamma}M$ direction is also presented in the paper. The finite-element method has been employed to calculate the transmitted power spectrum, which is in good agreement with the experimental results. The calculated displacement configurations at the frequency inside and out of the bandgaps illustrate the generation mechanism of the gaps.
Tumor Colonization and Therapy by Escherichia coli Nissle 1917 Strain in Syngeneic Tumor-Bearing Mice Is Strongly Affected by the Gut Microbiome

Simple Summary Cancer is a leading cause of disease-related death in humans and in domestic animals. Despite recent progress in the diagnosis and treatment of advanced cancer, the overall patient treatment outcome did not substantially improve. Bacterium-mediated cancer therapy is one promising method of cancer treatment. The most important challenges for the successful clinical use of bacteria are ensuring their preferential tumor colonization and initiating functional tumor-specific immunity. In the current work, we describe the influence of the gut microbiome on Escherichia coli Nissle 1917 (EcN) strain-mediated cancer therapy in a mouse tumor model. Here we demonstrate that gut microbiome modulation can be beneficial for colonization of EcN in tumor tissues and lead to improved survival of tumor-bearing mice treated with EcN. Abstract In the past, different bacterial species have been tested for cancer therapy in preclinical and clinical studies. The success of bacterial cancer therapy is mainly dependent on the ability of the utilized bacteria to overcome the host immune defense system to colonize the tumors and to initiate tumor-specific immunity. In recent years, several groups have demonstrated that the gut microbiome plays an important role of modulation of the host immune response and has an impact on therapeutic responses in murine models and in cohorts of human cancer patients. Here we analyzed the impact of the gut microbiome on tumor colonization and tumor therapy by the Escherichia coli Nissle 1917 (EcN) strain. This EcN strain is a promising cancer therapy candidate with probiotic properties. In our study, we observed significantly better tumor colonization by EcN after antibiotic-induced temporal depletion of the gut microbiome and after two intranasal applications of the EcN derivate (EcN/pMUT-gfp Knr) in 4T1 tumor-bearing syngeneic BALB/c mice. In addition, we demonstrated significant reduction in tumor growth and extended survival of the EcN-treated mice in contrast to phosphate-buffered saline (PBS)-treated tumor-bearing control animals. Multispectral imaging of immune cells revealed that depletion of the gut microbiome led to significantly lower infiltration of cytotoxic and helper T cells (CD4 and CD8 cells) in PBS tumors of mice pretreated with antibiotics in comparison with antibiotic untreated PBS—or EcN treated mice. These findings may help in the future advancement of cancer treatment strategies using E. coli Nissle 1917.
Analysis of geoelectric sections and surface impedance of the layered medium of Palestine and Tanzania

Geoelectric sections of some areas of Palestine and Tanzania were determined based on fund materials of vertical electrical soundings (VES). They are required to verify the predictive maps of the parameters of the geoelectric sections of the Earth's continents. Geoelectric sections obtained on the sea sandy beaches of Palestine washed by the waters of the Mediterranean Sea and on the rock complexes of Tanzania are presented. Using the VES parameters, the frequency dependences of the surface impedance of various types of rocks were calculated in the range from 10 kHz to 30 MHz. Layered geoelectric structures with strongly inductive surface impedance have been established.
Multiplicative Piecewise Gamma in Survival Data Analysis

The proportional hazard model is the most general of the regression models since it is not based on any assumptions concerning the nature or shape of the underlying survival distribution. The model assumes that the underlying hazard rate is a function of the covariates (independent variables) and there are no assumptions about the nature or shape of the hazard function. Proportional hazards model in survival analysis is used to estimate the effects of different covariates which was influenced by the survival data. This paper proposes the new multiplicative piecewise gamma in the hazard function using OpenBugs Statistical Packages. The proposed model is a flexible survival model for any types of non-informative censored data in estimating the parameters using Bayesian approach and also an alternative model to the existing model. We used the Markov Chain Monte Carlo method in computing the Bayesian estimator on leukemia data. The results obtained show that the proposed model can be an alternative to the existing multiplicative model since it can estimate the parameters using any types of survival data compared to the existing model that can only be used for leukemia data.
On the Delayed van der Pol Oscillator with Time-Varying Feedback Gain

This work studies the effect of time delayed feedback on stationary solutions in a van derPol type system. We consider the case where the feedback gain is harmonically modulated with a resonantfrequency. Perturbation analysis is conducted to obtain the modulation equations near primaryresonance, the stability analysis for stationary solutions is performed and bifurcation diagram is determined.It is shown that the modulated feedback gain position can influence significantly the steadystates behavior of the delayed van der Pol oscillator. In particular, for appropriate values of the modulateddelay parameters, the existence region of the limit cycle (LC) can be increased or quenched.Moreover, new regions of quasiperiodic vibration may emerge for certain values of the modulatedgain. Numerical simulation was conducted to validate the analytical predictions.
Modeling and Simulation of PGGP Electrode Configuration for Ion-Extraction Process Using 2.5D-PIC Code

The ion extraction from laser-induced photoplasma in an electrostatic field is investigated by a 2.5-D-electrostatic particle-in-cell (PIC) code. The external electrostatic field is applied by a plate–grid–grid–plate (PGGP) electrode configuration. In this configuration, two additional grids are introduced in a parallel plate electrode configuration. Basically, these grids are kept at more negative potential than the cathode, and therefore, the grid extracts the ion, whereas plates collect the ions. Through such biasing, the sputtering of the already collected ions on the collecting plate can be avoided. The present investigation emphasizes on spatiotemporal evolution of photoplasma in the PGGP electrode configuration. Subsequently, investigate the performance of this electrode configuration with different biasing of electric potential. Finally, it compares the performance of PGGP with parallel plate and M-type electrode configurations. Based on this comparative analysis, an improved design of the PGGP electrode configuration is suggested. In addition, it also explains modeling aspects of different electrode geometries using 2.5-D-PIC, which includes the boundary conditions for Poisson’s equation, particle boundary conditions, and grid designing.
Physical and numerical model of electrocoagulation process with aluminum electrodes for phosphate removal

The efficiency of the electrocoagulation process for the removal of phosphate ions 34 (PO -P) − has been analyzed using a batch full-scale reactor with aluminum electrodes. The effects of the flow rate through the reactor applied current density, and reactor volume were the focus of the study. The initial 34 (PO -P) − concentration was reduced by 90% after 90 min of reactor operation time. Additionally, a three-dimensional numerical model for 34 PO -P − removal via the electrocoagulation process is devel-oped that includes the processes of phosphate adsorption and desorption on coagulated/flocculated particles, along with particles settling. Numerical model parametrization relies on the results from the experiments.
ROBUST ADAPTIVE CONTROL OF PIEZOELECTRIC ACTUATORS WITH AN APPLICATION TO INTRACYTOPLASMIC SPERM INJECTION

This paper describes a robust adaptive control method for positioning piezoelectric actuators (ultrasonic motor) to achieve highly precise motion. The model employed to describe the motor is a second‐order linear model plus a nonlinear part comprising predominantly of a dynamical hysteresis. Based on the model, the overall control algorithm uses a PID component and an adaptive robust component for estimating the parameters of the piezo motor model. The adaptive component is continuously refined based on just prevailing input and output signals. Real‐time experimental results are provided to verify the effectiveness of the proposed scheme when applied to high precision motion trajectory tracking such as Intracytoplasmic Sperm Injection (ICSI).
Identification of C. elegans ASNA-1 domains and tissue requirements that differentially influence platinum sensitivity and growth control

ASNA1 plays an essential role in cisplatin chemotherapy response, type 2 diabetes, and heart disease. It is also an important biomarker in the treatment response of many diseases. Biochemically, ASNA1 has two mutually exclusive redox-modulated roles: a tail-anchored protein (TAP) targeting function in the reduced state and a holdase/chaperone function in the oxidized state. Assigning biochemical roles of mammalian ASNA1 to biomedical functions is crucial for successful therapy development. Our previous work showed the relevance of the C. elegans ASNA-1 homolog in modeling cisplatin response and insulin secretion. Here we analyzed two-point mutants in highly conserved residues in C. elegans ASNA-1 and determined their importance in separating the cisplatin response function from its roles in insulin secretion. asna-1(ΔHis164) and asna-1(A63V) point mutants, which both preferentially exist in the oxidized state, displayed cisplatin sensitivity phenotype as well as TAP insertion defect but not an insulin secretion defect. Further, using targeted depletion we analyzed the tissue requirements of asna-1 for C. elegans growth and development. Somatic depletion of ASNA-1 as well as simultaneous depletion of ASNA-1 in neurons and intestines resulted in an L1 arrest. We concluded that, targeting single residues in ASNA-1 affecting Switch I/Switch II domain function, in comparison to complete knockdown counteracted cisplatin resistance without jeopardizing other important biological functions. Taken together, our study shows that effects on health caused by ASNA1 mutations can have different biochemical bases.
Modelling the motion of particles around choanoflagellates

The three-dimensional particle paths due to a helical beat pattern of the flagellum of a sessile choanoflagellate, Salpingoeca Amphoridium (SA), are modelled and compared to the experimental observations of Pettitt (2001). The organism’s main components are a flagellum and a cell body which are situated above a substrate such that the interaction between these entities is crucial in determining the fluid flow around the choanoflagellate. This flow of fluid can be characterized as Stokes flow and a flow field analogous to one created by the flagellum is generated by a distribution of stokeslets and dipoles along a helical curve. The model describing the flow considers interactions between a slender flagellum, an infinite flat plane (modelling the substrate) and a sphere (modelling the cell body). The use of image systems appropriate to Green’s functions for a sphere and plane boundary are described following the method of Higdon (1979a). The computations predict particle paths representing passive tracers from experiments and their motion illustrates overall flow patterns. Figures are presented comparing recorded experimental data with numerically generated results for a number of particle paths. The principal results show good qualitative agreement with the main characteristics of flows observed in the experimental study of Pettitt (2001).
The Influence of Acitretin on Brain Lipidomics in Adolescent Mice—Implications for Pediatric and Adolescent Dermatological Therapy

Administration of systemic retinoids such as acitretin has not been approved yet for pediatric patients. An adverse event of retinoid-therapy that occurs with lower prevalence in children than in adults is hyperlipidemia. This might be based on the lack of comorbidities in young patients, but must not be neglected. Especially for the development of the human brain up to young adulthood, dysbalance of lipids might be deleterious. Here, we provide for the first time an in-depth analysis of the influence of subchronic acitretin-administration on lipid composition of brain parenchyma of young wild type mice. For comparison and to evaluate the systemic effect of the treatment, liver lipids were analogously investigated. As expected, triglycerides increased in liver as well as in brain and a non-significant increase in cholesterol was observed. However, specifically brain showed an increase in lyso-phosphatidylcholine and carnitine as well as in sphingomyelin. Group analysis of lipid classes revealed no statistical effects, while single species were tissue-dependently changed: effects in brain were in general more subtly as compared to those in liver regarding the mere number of changed lipid species. Thus, while the overall impact of acitretin seems comparably small regarding brain, the change in individual species and their role in brain development and maturation has to be considered.
CEEMDAN-IPSO-LSTM: A Novel Model for Short-Term Passenger Flow Prediction in Urban Rail Transit Systems

Urban rail transit (URT) is a key mode of public transport, which serves for greatest user demand. Short-term passenger flow prediction aims to improve management validity and avoid extravagance of public transport resources. In order to anticipate passenger flow for URT, managing nonlinearity, correlation, and periodicity of data series in a single model is difficult. This paper offers a short-term passenger flow prediction combination model based on complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN) and long-short term memory neural network (LSTM) in order to more accurately anticipate the short-period passenger flow of URT. In the meantime, the hyperparameters of LSTM were calculated using the improved particle swarm optimization (IPSO). First, CEEMDAN-IPSO-LSTM model performed the CEEMDAN decomposition of passenger flow data and obtained uncoupled intrinsic mode functions and a residual sequence after removing noisy data. Second, we built a CEEMDAN-IPSO-LSTM passenger flow prediction model for each decomposed component and extracted prediction values. Third, the experimental results showed that compared with the single LSTM model, CEEMDAN-IPSO-LSTM model reduced by 40 persons/35 persons, 44 persons/35 persons, 37 persons/31 persons, and 46.89%/35.1% in SD, RMSE, MAE, and MAPE, and increase by 2.32%/3.63% and 2.19%/1.67% in R and R2, respectively. This model can reduce the risks of public health security due to excessive crowding of passengers (especially in the period of COVID-19), as well as reduce the negative impact on the environment through the optimization of traffic flows, and develop low-carbon transportation.
Occurrence and clinical outcome of lateral wall fractures in proximal femoral fractures whose fracture line runs from femoral basal neck to subtrochanteric area

Treatment methods for proximal femoral fractures, when the fractures run from the femoral basal neck to the subtrochanteric area, have not yet been fully reported. Thus, we aimed to clarify osteosynthesis methods based on the fracture frequency and clinical results. We classified the proximal femoral fractures using the Area classification method based on the location (area) of the fracture line. The proximal femur has 4 areas with 3 boundaries; the center of the femoral neck, the boundary between femoral neck and trochanter, and the plane connecting the lower ends of the greater trochanter and the lesser trochanter. Fractures occurring only in Area-1 (proximal from the center of the femoral neck) were classified as Type 1; those in both Areas 1 and 2 (base of the femoral neck) were classified as Type 1-2. Therefore, fractures running from femoral basal neck to the subtrochanteric area were classified as Type 2-3-4. We targeted 60 Type 2-3-4 cases (average age 81 years, 10 men, 50 women) out of 1042 proximal femoral fracture cases who visited 8 hospitals in 2 years. We investigated the presence or absence of lateral trochanteric wall fractures, the selection of internal fixator, and the proportion of poor results. The lateral trochanteric wall fracture was observed in 48% of subjects. Long nails were selected to treat 46% cases, and nails with 2 or 3 proximal lag screws were used in 58% cases. Long nails and those with 2 or 3 lag screws were also used in 59% and 69% of lateral trochanteric wall fractures. Poor results such as cutout or excessive telescoping of lag screw occurred in 11.7% of cases and 17.2% of lateral trochanteric wall fractures. Even in cases where long nails and multiple lag screws were used for femoral trochanteric fractures whose fracture line ran from the femoral basal neck to subtrochanteric area were used, the failure rate was high in the presence of a lateral wall fracture. Therefore, it is necessary to consider careful post-operative treatment for proximal femoral fractures with lateral wall fracture, whose fracture line runs from femoral basal neck to subtrochanteric area.
Modeling of Nonlinearly Loaded Microwave Devices by a Wavelet Convolution Operator-Based Formulation

Abstract This article describes a fast and accurate method for the transient analysis of interconnection of networks with frequency-dependent parameters and nonlinear terminations by the use of an innovative wavelet-based convolution operator. This approach is useful to overcome the intrinsic difficulty of these kind of problems since nonlinear elements are better described in the time domain, and circuit components are mostly characterized in the frequency domain. A wavelet balance approach is discussed to solve the nonlinear equations arising from the presence of nonlinear terminations. Because of their generality and ease of use, the scattering parameters are utilized. Computational aspects are discussed, and the results of application of this technique are compared with those obtained by other methods. A very good agreement and reduced computational times have been obtained.
A Comparison of Observed and Simulated Properties of Sudden Stratospheric Warmings

Abstract Significant advances have been made recently both in observational studies and in dynamical numerical simulations of stratosphere warmings. Observed characteristics of warmings are reviewed, with discussion of the trajectory of warm cells, the vertical and horizontal scale of the warm-air systems, the time-scale of warming, circulation effects, initial zonal flow conditions before a warming, and details of the energy budget before and after warming. Distinctions are drawn between the 1973 and 1963 types of warmings, which involved a poleward advance of warm air in wave 1 and wave 2, respectively. In contrast to the warming of 1963, a strong baroclinic conversion of eddy potential to eddy kinetic energy was not discerned in 1973, but both events were preceded by extraordinarily large fluxes from the troposphere. The results of dynamical warming simulations by several investigators reflect varying degrees of success in reproducing observed features of warmings. The results of Matsuno and Newson clo.
Effect of lateral confinement on valence-band mixing and polarization anisotropy in quantum wires

The optical properties of high-quality V-groove GaAs/AlxGa1-xAs quantum wires have been investigated using low-temperature photoluminescence (PL) and photoluminescence excitation (PLE) techniques. We systematically study the evolution of PL and PLE spectra as a function of the wire size. This comparison allows us to analyze the modification of one-dimensional subbands with decreasing win thickness. We clarify the influence of surface corrugation and localization effects on PL and PLE spectra and we observe large polarization anisotropy unambiguously related to the one-dimensional character of our quantum wires. The results of a polarization analysis of the excitonic transitions are combined with a calculation of the electronic band structure to identify the nature of the transitions and the impact of two-dimensional quantum confinement on valence-band mixing. The observed large polarization anisotropy is directly compared to the effects predicted by a four-band k . p model calculation of the valence-band structure. The set of experimental results combined with our model calculations is consistent with a strong suppression of band-edge absorption in these one-dimensional structures. [S0163-1829(98)08319-2].