Miracle-dz/UniFAR-FTUs huggingface dataset:
An audit of head trauma care and mortality.

OBJECTIVE To analyze the factors contributing to deaths from head trauma by using standardized assessment parameters and to provide a peer-review of head injury deaths with focus on identifying deficiencies and analyzing contributory factors. DESIGN Descriptive study. PLACE AND DURATION OF STUDY The study was carried out at the Emergency, Aga Khan University Hospital during January 1998 to December 1999. SUBJECTS AND METHOD One hundred and three patients above the age of 15 years presenting alive to the Aga Khan University Hospital (AKUH) emergency with head injury were included in this study. Identified deaths data was reviewed by the Hospital Trauma Peer Review Committee and consensus arrived at for categorization of deaths. The potential deficiencies in care were identified and final recommendations made. The data was computed on CDC Trauma Registry (V 3.0) and SPSS (V 8.0). RESULTS Mean age was 31.9 years (n=103) with predominant male population (4:1). Severe head injury (GCS<8) accounted for 21.3 % (n=22) of all cases with a total number of deaths being 12.6 % (n=13). Deaths were categorized preventable in 3 cases with non-preventable and potentially preventable in 4 and 6 cases respectively. Road traffic accidents were the predominant mechanism (n=8) in all deaths (n=13). The time interval in relation to mortality was biphasic, most deaths occurring either within 24 hours or between 3-7 days of injury. Inappropriate pre-hospital treatment, pre-hospital delays and inappropriate mode of transportation without inter-hospital communication were the process-related defects in pre-hospital care with major determinant of deaths outside AKUH (n=5). Prolonged emergency stay, delayed intensive care availability were the process-related deficiencies whereas inappropriate initial resuscitation, inappropriate initial head injury management were provider-related deficiencies in in-hospital care. CONCLUSION Transfer of inappropriately managed patients, lapses in inter-hospital communications, delayed transfers were identified as the major pre-hospital factors whereas lack of ICU beds, portable ventilators in emergency room, delays in CT scan facilities were the deficiencies in the hospital services. Opportunities for improvement in head trauma care are needed to focus on initial resuscitation and appropriate surgical management.
Non-suicidal self-injury v. attempted suicide: new diagnosis or false dichotomy?

Summary Non-suicidal self-injury (NSSI) is a term that is becoming popular especially in North America and it has been proposed as a new diagnosis in DSM-5. In this paper we consider what self-harm research can tell us about the concept of NSSI and examine the potential pitfalls of introducing NSSI into clinical practice.
Database Systems - Concepts, Languages and Architectures

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A Novel Algorithm of Blind Detection of Frequency Hopping Signal Based on Second-Order Cyclostationarity

An algorithm to blindly detect frequency hopping (FH) signals corrupted by white Gaussian noise (WGN) is presented. Any parameters of FH are assumed to be unknown, and the noise power can be either known or unknown. The algorithm is based on the difference in cyclostationarity (CS) between FH signal and WGN. The module of estimation of cyclic autocorrelation is picked up with available received signal as the test statistic. A WGN of which power equals to the average power of received signal is constructed at the received end, and then the maximum module of estimation of cyclic autocorrelation is computed with this WGN as the detection threshold. Simulation results have proved that the proposed algorithm is adequate to the environments in which signal-to-noise ratio (SNR) is higher than -3dB.
High-efficiency X-band MMIC GaN power amplifiers with supply modulation

This paper presents measurement results on supply-modulated X-band 0. 15μm gate width GaN HEMT MMIC power amplifiers for OFDM signals. Two PAs at 10GHz with 4 and 10W output powers show peak CW efficiencies of 69% and 55%, with gains of 8.5 and 20.4 dB respectively. Supply modulation trajectories are designed by static characterization of each MMIC PA, and the drain modulation is performed though both a linear broadband modulator and a high-efficiency 5-MHz switching modulator. The PAs are tested in four modes: (1) with a constant 20-V supply and the 18-MHz OFDM signal input through the drive; (2) pure envelope tracking; (3) signal-split supply modulation; and (4) envelope elimination and restoration (EER) with a 5-MHz switching modulator. Average PAE and composite power added efficiencies are compared, reaching 65.4% and 35%, respectively, with the 4-W PA and a linear modulator.
Neutralization technique model using artificial neural networks

In this paper, a neuronal model based on artificial neural network (ANN) is developed to model the so called neutralization line isolation technique. This approach allows a faster analysis and design of multi-antenna systems based on two PIFAs mounted on a mobile phone type printed circuit board (PCB) with very significant time gain and accurate results compared to other electromagnetic simulation tools whether in analysis or design sense.
Evolutionary developmental genetics of fruit morphological variation within the Solanaceae

Morphological variations of fruits such as shape and size, and color are a result of adaptive evolution. The evolution of morphological novelties is particularly intriguing. An understanding of these evolutionary processes calls for the elucidation of the developmental and genetic mechanisms that result in particular fruit morphological characteristics, which determine seed dispersal. The genetic and developmental basis for fruit morphological variation was established at a microevolutionary time scale. Here, we summarize the progress on the evolutionary developmental genetics of fruit size, shape and color in the Solanaceae. Studies suggest that the recruitment of a pre-existing gene and subsequent modification of its interaction and regulatory networks are frequently involved in the evolution of morphological diversity. The basic mechanisms underlying changes in plant morphology are alterations in gene expression and/or gene function. We also deliberate on the future direction in evolutionary developmental genetics of fruit morphological variation such as fruit type. These studies will provide insights into plant developmental processes and will help to improve the productivity and fruit quality of crops.
A method for a categorized and probabilistic analysis of the surface electromyogram in dynamic contractions

The human motor system permits a wide variety of complex movements. Thereby, the inter-individual variability as well as the biomechanical aspects of the performed movement itself contribute to the challenge of the interpretation of sEMG signals in dynamic contractions. A procedure for the systematic analysis of sEMG recordings during dynamic contraction was introduced, which includes categorization of the data in combination with the analysis of frequency distributions of the sEMG with a probabilistic approach. Using the example of elbow flexion and extension the procedure was evaluated with 10 healthy subjects. The recorded sEMG signals of brachioradialis were categorized into a combination of constant and variable movement factors, which originate from the performed movement. Subsequently, for each combination of movement factors cumulative frequency distributions were computed for each subject separately. Finally, the probability of the difference of muscular activation in varying movement conditions was assessed. The probabilistic approach was compared to a deterministic analysis of the same data. Both approaches observed a significant change of muscular activation of brachioradialis during concentric and eccentric contractions exclusively for flexion and extension angles exceeding 30°. However, with the probabilistic approach additional information on the likelihood that the tested effect occurs can be provided. Especially for movements under uncontrollable boundary conditions, this information to assess the confidence of the detected results is of high relevance. Thus, the procedure provides new insights into the quantification and interpretation of muscular activity.
Learning CPG Sensory Feedback with Policy Gradient for Biped Locomotion for a Full-Body Humanoid

This paper describes a learning framework for a central pattern generator based biped locomotion controller using a policy gradient method. Our goals in this study are to achieve biped walking with a 3D hardware humanoid, and to develop an efficient learning algorithm with CPG by reducing the dimensionality of the state space used for learning. We demonstrate that an appropriate feed-back controller can be acquired within a thousand trials by numerical simulations and the obtained controller in numerical simulation achieves stable walking with a physical robot in the real world. Numerical simulations and hardware experiments evaluated walking velocity and stability. Furthermore, we present the possibility of an additional online learning using a hardware robot to improve the controller within 200 iterations.
“It Takes All Kinds”: A Simulation Modeling Perspective on Motivation and Coordination in Libre Software Development Projects

This paper presents a stochastic simulation model to study implications of the mechanisms by which individual software developers’ efforts are allocated within large and complex open source software projects. It illuminates the role of different forms of “motivations-at-the-margin” in the micro-level resource allocation process of distributed and decentralized multi-agent engineering undertakings of this kind. We parameterize the model by isolating the parameter ranges in which it generates structures of code that share certain empirical regularities found to characterize actual projects. We find that, in this range, a variety of different motivations are represented within the community of developers. There is a correspondence between the indicated mixture of motivations and the distribution of avowed motivations for engaging in FLOSS development, found in the survey responses of developers who were participants in large projects.
A computational model of intracellular oxygen sensing by hypoxia-inducible factor HIF1α

Hypoxia-inducible factor-1, HIF1, transcriptionally activates over 200 genes vital for cell homeostasis and angiogenesis. We developed a computational model to gain a detailed quantitative understanding of how HIF1 acts to sense oxygen and respond to hypoxia. The model consists of kinetic equations describing the intracellular variation of 17 compounds, including HIF1, iron, prolyl hydroxylase, oxygen, ascorbate, 2-oxoglutarate, von Hippel Lindau protein and associated complexes. We tested an existing hypothesis of a switch-like change in HIF1 expression in response to a gradual decrease in O2 concentration. Our model predicts that depending on the molecular environment, such as intracellular iron levels, the hypoxic response varies considerably. We show HIF1-activated cellular responses can be divided into two categories: a steep, switch-like response to O2 and a gradual one. Discovery of this dual response prompted comparison of two therapeutic strategies, ascorbate and iron supplementation, and prolyl hydroxylase targeting, to predict under what microenvironments either effectively increases HIF1α hydroxylation. Results provide crucial insight into the effects of iron and prolyl hydroxylase on oxygen sensing. The model advances quantitative molecular level understanding of HIF1 pathways - an endeavor that will help elucidate the diverse responses to hypoxia found in cancer, ischemia and exercise.
Bactericidal Activity in Whole Blood as a Potential Surrogate Marker of Immunity after Vaccination against Tuberculosis

ABSTRACT The development of new tuberculosis (TB) vaccines will require the identification of correlates of human protection. This study examined the balance between immunity and virulence in a whole blood infection model in which intracellular mycobacterial survival was measured using BACTEC. In the blood of tuberculin-negative donors, counts of Mycobacterium tuberculosis H37Ra organisms fell by 0.14 log10 CFU during 96 h of whole blood culture, whereas counts of Mycobacterium bovis BCG, M. tuberculosis H37Rv, and a clinical TB isolate's organisms increased by 0.13, 0.43, and 1.04 log10 CFU, respectively (P < 0.001), consistent with their relative virulence. Inhibition of tumor necrosis factor alpha by the addition of methylprednisolone or pentoxifylline or removal of CD4+ or CD8+ T cells by magnetic beads had deleterious effects on immune control of intracellular growth only in the blood of tuberculin-positive donors. Repeated vaccination of eight tuberculin-negative volunteers with M. bovis BCG resulted in a 0.3 log (50%) reduction in BCG CFU counts in the model compared to baseline values (P < 0.05). Three of the volunteers responded only after the second vaccination. These experiments indicate that whole blood culture may be used to measure immunity to M. tuberculosis and that further studies of repeated BCG vaccination are warranted.
Passively Q-switched diode-pumped Yb:YAG laser using Cr4+-doped garnets

We investigated the operation of a diode-pumped Yb:YAG laser passively Q-switched, by Cr4+:YAG, Cr4+:LuAG, and Cr4+:GSGG saturable absorbers. The results presented here are focused towards the design of a passively Q-switched Yb:YAG microlaser. The free-running performance of both rod and a disk Yb:YAG is characterized, and experimental parameters such as gain and loss are evaluated. These values, together with the value of the stimulated emission cross section, e.g. (sigma) emequals3.3x10-20 cm2 were found to fit between our experimental results and an existing numerical model which relates the experimental and physical parameters to the minimal threshold pumping power. Q-switched pulses with maximum peak power of approximately equals 10.4-kW, and energy of approximately equals 0.5 mJ/pulse were extracted with 30% extraction efficiency.
Orientation as an additional User Interface in Mixed-Reality Environments

This paper presents an augmented reality system that makes use of a consumer-level mobile device equipped with an inertial orientation sensor. The device maps orientational information to user interactions. Furthermore, we utilize orientation to determine portions of the operator’s context. The system makes use of the locationand context-aware platform Nexus [HKL99] to further refine the user’s context information. To evaluate the acceptance of the presented system a user study was performed.
Hypotensive Effect of Captopril Role of Bradykinin and Prostaglandinlike Substances

Captopril (0.15–10 mg/kg) administration in the anesthetized dog causes immediate hypotension concomitant with an increase in tonus of the assay tissue (cat terminal ileum) superfused with circulating blood (Vane's cascade method). The increase in cat terminal ileum tonus was antagonized by a bradykinin receptor antagonist, L-349b. Treatment of the animals with indomethacin blocked or reversed the hypotensive effect of captopril without affecting the increase in tonus of the cat terminal ileum. Captopril potentiated the hypotension induced by bradykinin injected intra-arterially, and indomethadn reduced the hypotensive effect of intra-arterially injected bradykinin. Addition of captopril or enalapril to the superfusing blood maintained at 37° C in an extracorporeal circuit caused a long-lasting increase in the tonus of the cat terminal ileum. The present results support the hypothesis that immediate hypotension induced by captopril involves a prostaglandin-dependent component possibly resulting from increased bradykinin levels generated in the vicinity of captopril action.
On linear deterministic interference channels with partial feedback

We consider the linear deterministic interference channel with partial feedback, in which a given number of the top most-significant-bits of the channel outputs of the receivers are fed back to the respective transmitters. The motivation for studying this channel is that it can approximate the Gaussian interference channel with noisy feedback, i.e., additive white Gaussian noise corrupted output feedback. We show that even when the feedback link is noisy, feedback still can help the system to have a larger sum-capacity by allowing users to cooperate and to manage interference better than the case without feedback. We also compare the partial feedback model to other models, including noiseless rate-limited feedback.
Hubs with Network Motifs Organize Modularity Dynamically in the Protein-Protein Interaction Network of Yeast

Background It has been recognized that modular organization pervades biological complexity. Based on network analysis, ‘party hubs’ and ‘date hubs’ were proposed to understand the basic principle of module organization of biomolecular networks. However, recent study on hubs has suggested that there is no clear evidence for coexistence of ‘party hubs’ and ‘date hubs’. Thus, an open question has been raised as to whether or not ‘party hubs’ and ‘date hubs’ truly exist in yeast interactome. Methodology In contrast to previous studies focusing on the partners of a hub or the individual proteins around the hub, our work aims to study the network motifs of a hub or interactions among individual proteins including the hub and its neighbors. Depending on the relationship between a hub's network motifs and protein complexes, we define two new types of hubs, ‘motif party hubs’ and ‘motif date hubs’, which have the same characteristics as the original ‘party hubs’ and ‘date hubs’ respectively. The network motifs of these two types of hubs display significantly different features in spatial distribution (or cellular localizations), co-expression in microarray data, controlling topological structure of network, and organizing modularity. Conclusion By virtue of network motifs, we basically solved the open question about ‘party hubs’ and ‘date hubs’ which was raised by previous studies. Specifically, at the level of network motifs instead of individual proteins, we found two types of hubs, motif party hubs (mPHs) and motif date hubs (mDHs), whose network motifs display distinct characteristics on biological functions. In addition, in this paper we studied network motifs from a different viewpoint. That is, we show that a network motif should not be merely considered as an interaction pattern but be considered as an essential function unit in organizing modules of networks.
The Fifth Metaheuristics International Conference mic 03-067-1 A hybrid network flow tabu search heuristic for the minimum shift design problem

The minimum shift design problem (MSD) is a scheduling problem that commonly arises in workforce management activities. Given a collection of shifts and workforce requirements, the problem consists in finding a minimum cardinality set of work shifts, and the number of workers to assign to each shift, in order to meet (or minimize the deviation from) prespecified staff requirements. This problem reduces to a special case of the minimum edge-cost flow problem (MECF ) for which a logarithmic hardness of approximation lower bound can be shown. We propose a two-stage heuristic for MSD . The first stage, inspired by the relation between the MSD and MECF problems, is based on a greedy heuristic that relies on a mincost max-flow (MCMF ) subroutine. The second stage is a composite tabu search procedure based on the interleaving of different neighborhood definitions. We compare our heuristic with
A Review of Self‐Healing Concrete for Damage Management of Structures

The increasing concern for safety and sustainability of structures is calling for the development of smart self‐healing materials and preventive repair methods. The appearance of small cracks (<300 µm in width) in concrete is almost unavoidable, not necessarily causing a risk of collapse for the structure, but surely impairing its functionality, accelerating its degradation, and diminishing its service life and sustainability. This review provides the state‐of‐the‐art of recent developments of self‐healing concrete, covering autogenous or intrinsic healing of traditional concrete followed by stimulated autogenous healing via use of mineral additives, crystalline admixtures or (superabsorbent) polymers, and subsequently autonomous self‐healing mechanisms, i.e. via, application of micro‐, macro‐, or vascular encapsulated polymers, minerals, or bacteria. The (stimulated) autogenous mechanisms are generally limited to healing crack widths of about 100–150 µm. In contrast, most autonomous self‐healing mechanisms can heal cracks of 300 µm, even sometimes up to more than 1 mm, and usually act faster. After explaining the basic concept for each self‐healing technique, the most recent advances are collected, explaining the progress and current limitations, to provide insights toward the future developments. This review addresses the research needs required to remove hindrances that limit market penetration of self‐healing concrete technologies.
The molecular basis of skeletal muscle weakness in a mouse model of inflammatory myopathy.

OBJECTIVE It is generally believed that muscle weakness in patients with polymyositis and dermatomyositis is due to autoimmune and inflammatory processes. However, it has been observed that there is a poor correlation between the suppression of inflammation and a recovery of muscle function in these patients. This study was undertaken to examine whether nonimmune mechanisms also contribute to muscle weakness. In particular, it has been suggested that an acquired deficiency of AMP deaminase 1 (AMPD1) may be responsible for muscle weakness in myositis. METHODS We performed comprehensive functional, behavioral, histologic, molecular, enzymatic, and metabolic assessments before and after the onset of inflammation in a class I major histocompatibility complex (MHC)-transgenic mouse model of autoimmune inflammatory myositis. RESULTS Muscle weakness and metabolic disturbances were detectable in the mice prior to the appearance of infiltrating mononuclear cells. Force contraction analysis of muscle function revealed that weakness was correlated with AMPD1 expression and was myositis specific. Decreasing AMPD1 expression resulted in decreased muscle strength in healthy mice. Fiber typing suggested that fast-twitch muscles were converted to slow-twitch muscles as myositis progressed, and microarray results indicated that AMPD1 and other purine nucleotide pathway genes were suppressed, along with genes essential to glycolysis. CONCLUSION These data suggest that an AMPD1 deficiency is acquired prior to overt muscle inflammation and is responsible, at least in part, for the muscle weakness that occurs in the mouse model of myositis. AMPD1 is therefore a potential therapeutic target in myositis.
A v-SNARE implicated in intra-Golgi transport

We report the identification of a putative v-SNARE (GOS-28), localized primarily to transport vesicles at the terminal rims of Golgi stacks. In vitro, GOS-28, A Golgi SNARE of 28 kD, is efficiently packaged into Golgi-derived vesicles, which are most likely COPI coated. Antibodies directed against GOS-28 block its ability to bind alpha-SNAP, partially inhibit transport from the cis to the medial cisternae, and do not inhibit budding of COP-coated vesicles, but do accumulate docked uncoated vesicles.