Miracle-dz/UniFAR-FTUs huggingface dataset:
Artifact-based software process improvement and management: a method proposal

When it comes to software process improvement (SPI), process engineers look for SPI methods to support process analysis, design, realization, deployment, and management. Although a number of different SPI methods and models exist, process engineers tend to view these as too generic, too large, or a poor fit for the organization in which SPI is conducted. A strategy to overcome these shortcomings is to concentrate on the artifacts, which precisely define the desired outcomes, rather than on specific methods. In this paper, we present the Artifact-based Software Process Improvement & Management (ArSPI) model that provides a unified perspective on SPI and company-wide software process management (SPM), the required key artifacts, and the life cycle models. ArSPI is shown to be of practical support to industry who called for a practical way to define the interfaces between SPI projects. This paper concludes with an example of how ArSPI paved the way for several organizations through applying the model in real-world SPI-projects.
Absorption of colostral immunoglobulins in newborn calves.

Abstract Passive immunity to some infectious agents is transferred from the cow to calf via colostrum. Transfer is by an apical tubular system in the intestinal absorptive cells for a limited time after birth. Uptake of macromolecules into the cells appears to be nonselective; however, some substances are not transferred to the blood. Cessation of transfer of material from the epithelial cells to blood occurs spontaneously at a progressively increased rate after 12h of age with mean closure time at approximately 24h. Proportions of the different classes of immunoglobulins in serum of calves after ingestion of colostrum reflect the proportions in colostrum when absorption is completed. Variation among calves in serum concentration of immune is wide. Amount of total γ -globulin or IgG ingested per unit of body weight soon after birth is the most important factor determining concentration of these in serum. In contrast, efficiency of absorption of IgM decreases as intake increases, so that ingestion of a larger amount of IgM does not increase the absolute amount absorbed. Absorption efficiency is decreased when ingestion of first colostrum is delayed, indicating the importance of colostrum intake soon after birth. Even more important is that transmigration of pathogenic bacteria can be prevented by colostrum in the intestinal lumen.
DNA and personality

The purpose of this paper is to describe new genetic approaches that are beginning to identify genes for personality and to consider how these findings will affect personality research in the future. Genetic approaches to complex traits such as personality have moved from single‐gene models and methods to approaches that can identify genes of small effect size in multiple‐gene systems called quantitative trait loci (QTLs). We review results for the association between dopamine D4 receptor (DRD4) and novelty seeking, which was the first QTL association reported for personality. The identification of QTLs will revolutionize genetic research on personality by providing measured genotypes for tracking the developmental course of genetic effects, for investigating genetic links between traits and between personality and biological mechanisms, and for identifying interactions and correlations between genes and environment. © 1998 John Wiley & Sons, Ltd.
Identification to proximal targets and affective organizational commitment: The mediating role of organizational identification

The present study aims to investigate the contribution of identification to proximal targets in the prediction of affective organizational commitment. Using three sets of cross-sectional data, we found that organizational identification mediates the impact of both occupational and workgroup identification on affective organizational commitment. We also examined the relationship between organizational identification and affective organizational commitment and their effects on two of their common outcomes, that is, job satisfaction and turnover intentions. Our results showed that affective organizational commitment mediates the effect of organizational identification on job satisfaction and turnover intentions.
The oval sphere vs. the flat canvas

3D cinema is heading towards self-sufficient maturity both technically and aesthetically. In this paper, I will undertake a comparative analysis of the distinctions between 3D and 2D cinema based on a correlation between techniques of production and perceptual physiologies. Moreover, with reference to Siegfried Kracauer's classic remark about cinematic ontology that “the nature of film is the redemption of physical reality” (1961), I will argue for 3D's greater ability to retrieve “physical reality” than 2D cinema through ontological comparisons between the two media. I will further elicit aesthetic values for 3D cinema based on the above argument and illustrate the grounds of artistic differentiation between 3D and 2D visuality and viscerality by comparing the extreme slow motion aesthetics utilised in brutally violent scenes in Dredd 3D (2012) with those in the 2D film Killing Them Softly (2012).
Case Report and Mini Literature Review: Anesthetic Management for Severe Peripartum Cardiomyopathy Complicated with Preeclampsia Using Sufetanil in Combined Spinal Epidural Anesthesia

Peripartum cardiomyopathy (PPCM) is a rare entity, and anesthetic management for cesarean section of a patient with this condition can be challenging. We hereby present the anesthetic management of a patient with PPCM complicated with preeclampsia scheduled for cesarean section, along with a mini review of literature. A 24 year-old primigravida with twin gestation was admitted to our hospital with severe PPCM and preeclampsia for peripartum care, which finally required a cesarean section. Preoperative optimization was done according to the goal of managing left ventricular failure. Combined spinal epidural (CSE) anaesthesia with bupivacaine and sufentanil was used for cesarean section under optimal monitoring. The surgery was completed without event or complication. Postoperative pain relief was adequate and patient required only one epidural top up with sufentanil 6 hours after operation. To the best of our knowledge there is no report in literature of the use of sufentanil as a neuraxial opioid in the anesthetic management of cesarean section in a patient with PPCM. CSE with sufentanil may be a safer and more effective alternative in such cases.
Reasons to believe: Participants' explanations of trust in an outsourcing relationship

The nature of trust in an information systems outsourcing relationship is examined by considering the explanations for trust or distrust offered by individuals working at the boundary between the two organisations. Previous studies of trust in outsourcing situations have focused either on evidential bases of trust or the process of the development of trusting relationships. This study takes an institutional perspective and examines how trust may be shaped by the institutional norms of the trustors and the trustees. Interviews with ‘boundary spanners’ suggest that trusting decisions can be explained by reference to an implicit set of rules that govern ‘normal’ behaviour in outsourcing relationships. However, competing sets of rules and contested meanings of these rules arising from different interpretations of the institutional context were implicated in conflict and trust erosion. This case study contributes an alternative viewpoint to the body of research on trust in outsourcing relationships and adds to our understanding of how institutional contexts may influence trust in these business-to-business relationships. Further research on the nature and elicitation of rules and potential organisational interventions is suggested.
Management and investigation of neonatal encephalopathy: 2017 update

This review discusses an approach to determining the cause of neonatal encephalopathy, as well as current evidence on resuscitation and subsequent management of hypoxic-ischaemic encephalopathy (HIE). Encephalopathy in neonates can be due to varied aetiologies in addition to hypoxic-ischaemia. A combination of careful history, examination and the judicious use of investigations can help determine the cause. Over the last 7 years, infants with moderate to severe HIE have benefited from the introduction of routine therapeutic hypothermia; the number needed to treat for an additional beneficial outcome is 7 (95% CI 5 to 10). More recent research has focused on optimal resuscitation practices for babies with cardiorespiratory depression, such as delayed cord clamping after establishment of ventilation and resuscitation in air. Around a quarter of infants with asystole at 10 min after birth who are subsequently cooled have normal outcomes, suggesting that individualised decision making on stopping resuscitation is needed, based on access to intensive treatment unit and early cooling. The full benefit of cooling appears to have been exploited in our current treatment protocols of 72 hours at 33.5°C; deeper and longer cooling showed adverse outcome. The challenge over the next 5–10 years will be to assess which adjunct therapies are safe and optimise hypothermic brain protection in phase I and phase II trials. Optimal care may require tailoring treatments according to gender, genetic risk, injury severity and inflammatory status.
The association between COPD and heart failure risk: a review

Chronic obstructive pulmonary disease (COPD) is commonly associated with heart failure (HF) in clinical practice since they share the same pathogenic mechanism. Both conditions incur significant morbidity and mortality. Therefore, the prognosis of COPD and HF combined is poorer than for either disease alone. Nevertheless, usually only one of them is diagnosed. An active search for each condition using clinical examination and additional tests including plasma natriuretic peptides, lung function testing, and echocardiography should be obtained. The combination of COPD and HF presents many therapeutic challenges. The beneficial effects of selective β1-blockers should not be denied in stable patients who have HF and coexisting COPD. Additionally, statins, angiotensin-converting enzyme inhibitors, and angiotensin-receptor blockers may reduce the morbidity and mortality of COPD patients. Moreover, caution is advised with use of inhaled β2-agonists for the treatment of COPD in patients with HF. Finally, noninvasive ventilation, added to conventional therapy, improves the outcome of patients with acute respiratory failure due to hypercapnic exacerbation of COPD or HF in situations of acute pulmonary edema. The establishment of a combined and integrated approach to managing these comorbidities would seem an appropriate strategy. Additional studies providing new data on the pathogenesis and management of patients with COPD and HF are needed, with the purpose of trying to improve quality of life as well as survival of these patients.
In Vitro and In Silico Risk Assessment in Acquired Long QT Syndrome: The Devil Is in the Details

Acquired long QT syndrome, mostly as a result of drug block of the Kv11. 1 potassium channel in the heart, is characterized by delayed cardiac myocyte repolarization, prolongation of the T interval on the ECG, syncope and sudden cardiac death due to the polymorphic ventricular arrhythmia Torsade de Pointes (TdP). In recent years, efforts are underway through the Comprehensive in vitro proarrhythmic assay (CiPA) initiative, to develop better tests for this drug induced arrhythmia based in part on in silico simulations of pharmacological disruption of repolarization. However, drug binding to Kv11.1 is more complex than a simple binary molecular reaction, meaning simple steady state measures of potency are poor surrogates for risk. As a result, there is a plethora of mechanistic detail describing the drug/Kv11.1 interaction—such as drug binding kinetics, state preference, temperature dependence and trapping—that needs to be considered when developing in silico models for risk prediction. In addition to this, other factors, such as multichannel pharmacological profile and the nature of the ventricular cell models used in simulations also need to be considered in the search for the optimum in silico approach. Here we consider how much of mechanistic detail needs to be included for in silico models to accurately predict risk and further, how much of this detail can be retrieved from protocols that are practical to implement in high throughout screens as part of next generation of preclinical in silico drug screening approaches?
Confirming Allusions: Toward an Empirical Account of Action

As part of a larger effort to develop an empirically grounded theory of action, this article describes a previously undescribed action that occurs in talk-in-interaction. The practice of agreeing with another by repeating what they have said is shown to constitute the action of confirming an allusion-that is, confirming both its "content" and its prior inexplicit conveyance. The author reviews the past treatment of "action" in sociology and the key constraints on undertaking an empirically grounded account. The account of "confirming allusions" is offered to exemplify what this undertaking will involve: several instances of an unremarkable usage in conversation are displayed and used to formulate a puzzle, a database is developed for the exploration of the target usage, and a candidate solution to the puzzle is formulated, exemplified, and defended through a range of analytic techniques. The linkage between the practice and the action that it implements is analytically sketched by examining other uses of repetition in talk-in-interaction. In conclusion, the significance of both the theme and the analysis for studies of interaction and culture and for sociological theory is discussed.
Treatment of fabella syndrome with manual therapy: a case report.

STUDY DESIGN Clinical case report. OBJECTIVES To educate clinicians about fabella syndrome as a possible cause for posterolateral knee pain and dysfunction. Also to describe a physical therapy intervention strategy for posterolateral knee pain secondary to hypomobility or malposition of a fabella. BACKGROUND A 44-year-old, physically fit, Caucasian male with a 10-year history of left posterolateral knee pain and functional limitations during athletic activities, walking, and activities of daily living presented for evaluation and treatment. He had previously experienced relief of symptoms after experimenting with a mechanical maneuver administered by his wife. METHODS AND MEASURES A thorough examination for strength, range of motion, and accessory motions was performed. A fabella was palpable in the lateral head of the gastrocnemius muscle and a provisional diagnosis of fabella syndrome was made. While in a prone position, the patient received soft tissue mobilization of the lateral gastrocnemius, followed by medial, lateral, and inferior glides of the fabella. RESULTS The patient reported an immediate reduction in posterolateral knee pain and demonstrated a 30 degrees increase in active knee flexion. CONCLUSIONS Physical therapists may be unaware that fabella syndrome is a possible source of posterolateral knee pain and dysfunction. This simple manual therapy intervention was effective in reducing symptoms of pain and increasing tolerance for activities involving knee flexion, extension, and rotation. Physical therapists may wish to add this diagnosis and the corresponding examination and intervention techniques to their management strategy for patients with fabella syndrome.
Research Statement Scheduling Supercomputers: the Case for Load Unbalancing How Favoring Short Web Requests Can Improve Performance of All Improving System Performance under Transient Overload Conditions

In my research, I solve hard problems in computer systems by applying two key principles. First, I believe that major advances in systems research require a methodological approach, using analytical modeling, performance evaluation and statistical analysis of system behavior and workload. The derived knowledge not only provides the basis for a realistic performance evaluation of new system designs, but often provides insights that directly lead to new design ideas. Second, I believe that advances beyond simple incremental improvements of existing technology require an interdisciplinary approach, drawing on techniques from other disciplines, such as scheduling and queueing theory, control theory, statistics, and machine learning. In my research, I have applied these two principles to several areas in systems research, including high-performance computing systems [19, 21], Web servers [9, 7, 22, 23], computer networks [15], database systems [12, 13, 24, 25] and storage systems [20]. I give a brief overview of some of this work below.
Mechanisms of Amphetamine Action Revealed in Mice Lacking the Dopamine Transporter

Amphetamine (AMPH) inhibits uptake and causes release of dopamine (DA) from presynaptic terminals. AMPH can act on both vesicular storage of DA and directly on the dopamine transporter (DAT). To assess the relative importance of these two processes, we have examined the releasing actions of AMPH in mice with a genetic deletion of the DAT. The sequence of actions of AMPH has been determined by following the real time changes of DA in the extracellular fluid of intact tissue with fast scan cyclic voltammetry. In striatal slices from wild-type mice, AMPH causes a gradual (∼30 min) increase in extracellular DA, with a concomitant disappearance of the pool of DA available for depolarization-evoked release. Conversely, in slices from mice lacking the DAT, although a similar disappearance of electrically stimulated DA release occurs, extracellular DA does not increase. Similarly, microdialysis measurements of DA after AMPH in freely moving animals show no change in mice lacking the DAT, whereas it increases 10-fold in wild-type mice. In contrast, redistribution of DA from vesicles to the cytoplasm by the use of a reserpine-like compound, Ro4–1284, does not increase extracellular DA in slices from wild-type animals; however, subsequent addition of AMPH induces rapid (<5 min) release of DA. Thus, the DAT is required for the releasing action, but not the vesicle-depleting action, of AMPH on DA neurons, and the latter represents the rate-limiting step in the effects of AMPH. Furthermore, these findings suggest that in the absence of pharmacological manipulation, such as the use of amphetamine, endogenous cytoplasmic DA normally does not reach sufficient concentrations to reverse the DAT.
A Software Framework for Rapid Application-Specific Hybrid Photonic Network-on-Chip Synthesis

Network on Chip (NoC) architectures have emerged in recent years as scalable communication fabrics to enable high bandwidth data transfers in chip multiprocessors (CMPs). These interconnection architectures still need to conquer many challenges, e.g., significant power consumption and high data transfer latencies. Hybrid electro-photonic NoCs have been recently proposed as a solution to mitigate some of these challenges. However, with increasing application complexity, hardware dependencies, and performance variability, optimization of hybrid photonic NoCs requires traversing a massive design space. To date, prior work on software tools for rapid automated NoC synthesis have mainly focused on electrical NoCs. In this article, we propose a novel suite of software tools for effectively synthesizing hybrid photonic NoCs. We formulate and solve the synthesis problem using four search-based optimization heuristics: (1) Ant Colony Optimization (ACO); (2) Particle Swarm Optimization (PSO); (3) Genetic Algorithm (GA); and (4) Simulated Annealing (SA). Our experimental results show significant promise for the ACO and PSO based heuristics. Our novel implementation of PSO achieves an average of 64% energy-delay product improvements over GA and 53% improvement over SA; while our novel ACO implementation achieves 107% energy-delay product improvements over GA and 62% improvement over SA.
An Extremely Peramorphic Newt (Urodela: Salamandridae: Pleurodelini) from the Latest Oligocene of Germany, and a New Phylogenetic Analysis of Extant and Extinct Salamandrids

We describe an Oligocene newt specimen from western Germany that has gone practically unnoticed in the literature despite having been housed in the Museum für Naturkunde (Berlin) for a century. It is referable to the coeval Chelotriton, but is unusually peramorphic; for many characters it is more peramorphic than all other caudates or even all other lissamphibians. Most noticeable are the position of the jaw joints far caudal to the occiput, the honeycombed sculpture on the maxilla, and the possible presence of a septomaxilla (which would be unique among salamandrids). Referral to a species would require a revision of the genus, but the specimen likely does not belong to the type species. A phylogenetic analysis of nonmolecular characters of Salamandridae, far larger than all predecessors, confirms the referral to Chelotriton. It further loosely associates the Oligocene Archaeotriton and the Miocene Carpathotriton with the extant Lissotriton, though the former may alternatively lie outside Pleurodelinae altogether. The Miocene? I. randeckensis may not belong to the extant Ichthyosaura. The Miocene “Triturus” roehrsi is found neither with the extant Ommatotriton nor with Lissotriton, but inside an Asian/aquatic clade or, when geographic distribution is included as a character, as the sister-group to all other European molgins. The main cause for discrepancies between the results and the molecular consensus is not heterochrony, but adaptations to a life in mountain streams; this is the most likely reason why the Paleocene Koalliella from western Europe forms the sister-group to some or all of the most aquatic extant newts in different analyses. We would like to urge neontologists working on salamandrids to pay renewed attention to the skeleton, not limited to the skull, as a source of diagnostic and phylogenetically informative characters.
The 4CED Program

4CED attempts to put "under one roof" most of the operations that might be desirable for a musician developing a piece of music in a studio environment using real-time equipment. It also attempts to present this real-time equipment quite abstractly to allow a musician to be insulated from the internal workings of the machine while retaining access to the machine's possibilities. This prevents the program from being a toy that is quickly outgrown. 4CED and the 4C synthesizer itself are not only practical tools for music-making, but also steps in the development of knowledge about how to realize the potential of digital synthesis. Therefore it is within the proper domain of this paper to discuss inadequacies and compromises of 4CED and the improvements these suggest.