Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical predictors of suicidal acts after major depression in bipolar disorder: a prospective study.

OBJECTIVE This study determined the clinical predictors of suicidal behavior during a 2-year follow-up of patients with bipolar disorder presenting with a major depressive episode (MDE). METHOD Sixty four patients with DSM-III-R bipolar disorder were assessed at presentation for treatment of an MDE. Correlates of past suicidal behavior were determined by comparing patients with and without a history of suicide attempts using a t-test, Wilcoxon test or chi-squared test of independence on individual explanatory variables. Putative predictors of attempts during the follow-up period were tested separately using Cox proportional hazards regression analysis. RESULTS Twelve of 64 patients had at least one suicide attempt in the follow-up period, five of them attempted in the first 2 months and seven around or shortly after the 1-year follow-up visit. All attempters had a history of past suicide attempts. Most predictors of future suicidal behavior were correlates of past suicidal behavior. Family history of suicide acts and comorbid borderline personality disorder predicted early attempts, while younger age, high hostility scores, number of past attempts, subjective pessimism as reflected in depression and suicidal ideation, and few reported reasons for living predicted suicidal acts during the whole period. CONCLUSION In this data set of bipolar patients we noted an intriguing picture of two clusters of suicide attempts. Hostility was the strongest risk factor. These findings may have implications in both the identification of at-risk patients and the timing of clinical interventions including aggressive pharmacotherapeutic prophylaxis to prevent relapse or recurrence of depressive symptomatology.
Semantic effects on sensory-motor modality switching

ABSTRACT Language processing always involves a combination of sensory (auditory or visual) and motor modalities (vocal or manual). In line with embodied cognition theories, we additionally assume a semantically implied modality (SIM) due to modality references of the underlying concept. Understanding ear-related words (e.g. “noise”), for example, should activate the auditory SIM. In the present study, we investigated the influence of the SIM on sensory-motor modality switching (e.g. switching between the auditory-vocal and visual-manual combination). During modality switching, participants categorised words with regard to their SIM (e.g. ear- versus eye-related words). Overall performance was improved and switch costs were reduced whenever there was concordance between SIMs and sensory-motor modalities (e.g. an auditory presentation of ear-related words). Thus, the present study provides first evidence for semantic effects during sensory-motor modality switching in terms of facilitation effects whenever the SIM was in concordance with sensory-motor modalities.
[Cloning of prepronociceptin has led to the discovery of other biologically active peptides].

Among the opioid receptors family, the cloning of the mu, kappa and delta receptors was followed by that of another member, named ORL1 (Opiate Receptor Like 1). In spite of obvious homologies with the mu, kappa and delta receptors, ORL1 does not display a relevant affinity for the endogenous ligands of these former receptors (beta endorphin, enkephalins, dynorphin A.). This observation has prompted to search for an endogenous ligand of ORL1. A heptadecapeptide which fulfils this function, with a nanomolar affinity, has been found. It was named either nociceptin or orphanin FQ. It demonstrates, according either to the dose or to the route of administration, hyperalgesic, allodynic, antiopioidergic or even analgesic effects. It displays also many behavioural effects, modifying especially locomotion, exploratory behaviour, motivation, anxiety, memory, food intake. Nociceptin results from the cleavage of a large precursor protein, prepronociceptin (PPNOC). In this latter, nociceptin is flanked on its C-terminal region by another peptide which may be regarded either as a heptadecapeptide (NocII), or a bidecapeptide (NocIII) according to the inclusion or not of a fragment constituted by 3 arginine residues. Investigating the functions modulated by NocII, we observed that it stimulates locomotor activity of mice and shortens the forepaws licking latency in the hot plate test (55 degrees C); these effects are not shared by NocIII. The simultaneous administration of NocII and nociceptin resulted in animals put on the hot plate to the appearance of their respective effects, not modified by the presence of the other. A 41 amino acid peptide flanks nociceptin on its N-terminal region in PPNOC. It may be cleaved to generate a heptadecapeptide, named nocistatin on account of its antagonist effect on the hyperalgesia/allodynia induced by nociceptin. Thus, the discovery of ORL1 has led to that of nociceptin, that of its precursor PPNOC, and thereby to that of NocII/NocIII and nocistatin. The functions modulated by these peptides are being investigated whereas their receptors are yet unknown. These multiple targets allow to expect new strategies to modulate their functions.
Microtubules in the fungal pathogen Ustilago maydis are highly dynamic and determine cell polarity.

Many fungal pathogens undergo a yeast-hyphal transition during their pathogenic development that requires rearrangement of the cytoskeleton, followed by directed membrane traffic towards the growth region. The role of microtubules and their dynamic behavior during this process is not well understood. Here we set out to elucidate the organization, cellular role and in vivo dynamics of microtubules in the dimorphic phytopathogen Ustilago maydis. Hyphae and unbudded yeast-like cells of U. maydis contain bundles of spindle pole body-independent microtubules. At the onset of bud formation two spherical tubulin structures focus microtubules towards the growth region, suggesting that they support polar growth in G(2), while spindle pole body-nucleated astral microtubules participate in nuclear migration in M and early G(1). Conditional mutants of an essential alpha-tubulin gene from U. maydis, tub1, confirmed a role for interphase microtubules in determination of cell polarity and growth. Observation of GFP-Tub1 fusion protein revealed that spindle pole body-independent and astral microtubules are dynamic, with elongation and shrinkage rates comparable to those found in vertebrate systems. In addition, very fast depolymerization was measured within microtubule bundles. Unexpectedly, interphase microtubules underwent bending and rapid translocations within the cell, suggesting that unknown motor activities participate in microtubule organization in U. maydis. Movies available on-line: http://www.biologists. com/JCS/movies/jcs1792.html
A meta-analysis of the association between adherence to drug therapy and mortality

Abstract Objective To evaluate the relation between adherence to drug therapy, including placebo, and mortality. Design Meta-analysis of observational studies. Data sources Electronic databases, contact with investigators, and textbooks and reviews on adherence. Review methods Predefined criteria were used to select studies reporting mortality among participants with good and poor adherence to drug therapy. Data were extracted for disease, drug therapy groups, methods for measurement of adherence rate, definition for good adherence, and mortality. Results Data were available from 21 studies (46 847 participants), including eight studies with placebo arms (19 633 participants). Compared with poor adherence, good adherence was associated with lower mortality (odds ratio 0.56, 95% confidence interval 0.50 to 0.63). Good adherence to placebo was associated with lower mortality (0.56, 0.43 to 0.74), as was good adherence to beneficial drug therapy (0.55, 0.49 to 0.62). Good adherence to harmful drug therapy was associated with increased mortality (2.90, 1.04 to 8.11). Conclusion Good adherence to drug therapy is associated with positive health outcomes. Moreover, the observed association between good adherence to placebo and mortality supports the existence of the “healthy adherer” effect, whereby adherence to drug therapy may be a surrogate marker for overall healthy behaviour.
INK4a/ARF limits the expansion of cells suffering from replication stress

Replication stress (RS) is a source of DNA damage that has been linked to cancer and aging, which is suppressed by the ATR kinase. In mice, reduced ATR levels in a model of the ATR-Seckel syndrome lead to RS and accelerated aging. Similarly, ATR-Seckel embryonic fibroblasts (MEF) accumulate RS and undergo cellular senescence. We previously showed that senescence of ATR-Seckel MEF cannot be rescued by p53-deletion. Here, we show that the genetic ablation of the INK4a/Arf locus fully rescues senescence on ATR mutant MEF, but also that induced by other conditions that generate RS such as low doses of hydroxyurea or ATR inhibitors. In addition, we show that a persistent exposure to RS leads to increased levels of INK4a/Arf products, revealing that INK4a/ARF behaves as a bona fide RS checkpoint. Our data reveal an unknown role for INK4a/ARF in limiting the expansion of cells suffering from persistent replication stress, linking this well-known tumor suppressor to the maintenance of genomic integrity.
What Works, Under What Circumstances, and in What Ways?

Geisser, Robinson, and Riley present a stimulating conceptual model of coping with chronic pain in which the authors argue that maladaptive beliefs and coping are primary determinants of adjustment and influence adaptive beliefs and coping through their influence on perceptions of control. We discuss some aspects of the model that require further refinement. First, the assessments of beliefs, appraisals, and coping need to be independent of outcome, obviating the use of "adaptive" and "maladaptive" in conceptual models. Unqualified statements about the universal adaptive­ ness, or maladaptiveness, of appraisal and coping strategies are likely to be unusual, since some strate­ gies may result in higher emotional adjustment but not physical adjustment or vice versa. Second, beliefs, appraisals, and coping are distinct conceptual dimen­ sions. Conceptual models that delineate relevant dimensions of these constructs rather than unify these partially independent constructs will likely have greater utility.Third, broadening the conceptualization of pain appraisal to include the individual's interpreta­ tion of the meaning of the pain is likely to provide expanded understanding of the pain coping process. Fourth, factors active in the individual's environment, particularly social relationships, need to be integrated into any comprehensive model of coping with chronic pain. And fifth, the bidirectional relationships between beliefs, appraisals, and coping need to be integrated into conceptual models. These processes are interre­ lated and feed back to one another as the individual struggles to cope with the challenges and threat posed by pain. The inherent complexity of coping with pain requires conceptualizationsthat address its trans­ actional nature and methodologies that capture this
Regulation and Maintenance of an Adoptive T-Cell Dependent Memory B Cell Pool

We investigated the ability of monoclonal B cells to restore primary and secondary T-cell dependent antibody responses in adoptive immune-deficient hosts. Priming induced B cell activation and expansion, AID expression, antibody production and the generation of IgM+IgG- and IgM-IgG+ antigen-experienced B-cell subsets that persisted in the lymphopenic environment by cell division. Upon secondary transfer and recall the IgM-IgG+ cells responded by the production of antigen-specific IgG while the IgM+ memory cells secreted mainly IgM and little IgG, but generated new B cells expressing germinal center markers. The recall responses were more efficient if the antigenic boost was delayed suggesting that a period of adaptation is necessary before the transferred cells are able to respond. Overall these findings indicate that reconstitution of a functional and complete memory pool requires transfer of all different antigen-experienced B cell subsets. We also found that the size of the memory B cell pool did not rely on the number of the responding naïve B cells, suggesting autonomous homeostatic controls for naïve and memory B cells. By reconstituting a stable memory B cell pool in immune-deficient hosts using a monoclonal high-affinity B cell population we demonstrate the potential value of B cell adoptive immunotherapy.
Curriculum Readiness and Program Evaluation In Implementing Indonesian National Qualifications Framework Curriculum (KKNI)

Abstract The purpose of this study is to determine the study program readiness in State Islamic University (UIN) Jakarta in implementing KKNI based curriculum. It can be seen from the availability of the documents course curriculum in UIN Jakarta which consist s of 71% of the vision, mission, graduate profile, achievement of learning, the curriculum structure and Semester Lesson Plan (RPS). It also can be evidenced by the quality of the documents that 1) 99% of study programs have developed a vision and mission for the implementation of the curriculum. 2) 77% of study programs have developed a graduate profile according to level 6 of the KKNI based curriculum which is the basis for the development of graduate-level profile. 3) development of learning achievements in environmental studies program UIN Jakarta, 59% of the study programs have been formulated learning achievements which is in accordance with the learning outcomes defined for an undergraduate level. 4) 35% of the curriculum structure of the study program have met KKNI implementation standards. 5) development of Semester Lesson Plan (RPS) program in environmental studies UIN Jakarta, 82% of the Semester Lesson Plan or RPS which is in line with the principles of RPS development expected in the KKNI implementation has been developed by several study programs at UIN Jakarta . Abstrak Penelitian ini bertujuan untuk mengetahui kesiapan program studi di Universitas Islam Negeri (UIN) Syarif Hidayatullah Jakarta dalam mengimplementasikan Kurikulum berbasis KKNI. Kesiapan tersebut dapat dilihat melalui ketersediaan dokumen kurikulum program studi di UIN Jakarta yang terdiri dari 71% visi, misi, profil lulusan, capaian pembelajaran, Struktur Kurikulum dan Rencana Pembelajaran Semester (RPS). Selain itu, kesiapan program studi dalam mengaplikasikan dapat dibuktikan dari kualitas dokumen, yakni 1) 99% program studi telah mengembangkan visi dan misi untuk pelaksanaan kurikulum. 2)77% program studi telah mengambangkan profil lulusan menurut level 6 Kurikulum berbasis KKNI yang merupakan dasar untuk pengembangan profil lulusan. 3) pengembangan capaian pembelajaran di lingkungan program studi UIN Jakarta, 59% program studi telah merumuskan capaian pembelajaran yang sesuai dengan hasil belajar yang ditetapkan untuk program sarjana. 4) 35% struktur kurikulum program studi telah memenuhi standar pelaksanaan KKNI. 5) pengembangan Rencana Pembelajaran Semester (RPS) program studi di lingkungan UIN Jakarta, 82% dari Rencana Pembelajaran Semester atau RPS yang sejalan dengan prinsip-prinsip pengembangan RPS yang diharapkan dalam pelaksanaan KKNI telah dikembangkan oleh beberapa program studi di UIN Jakarta. How to Cite : Fauzan. , Latip A. , E. (2015). Curriculum Readiness and Program Evaluation in Implementing Indonesian National Qualifications Framework Curriculum (KKNI). TARBIYA: Journal Of Education In Muslim Society, 2 (2), 190-203. doi:10.15408/tjems.v2i2. 3179. Permalink/DOI: http://dx.doi. org/10.15408/tjems.v2i2. 3179
Generating marker stars for 6D optical tracking

Visually tracking a large number of objects remains a trade-off between accuracy and amount of data. For applications where high accuracy in both position and orientation of points in space is required, optical tracking systems with passive marker systems are suitable. However, the placement of the marker dots remains problematic, as distin-guishability between the marker alignments considerably reduces data pre- or post processing, as objects can be identified by the marker geometry and the identity and pose of marked objects does not have to be reconstructed from prior frames. We propose a method which automatically generates a set of unique marker stars in a selectable quantity. The proposed method generates structures which can be built using standard rapid prototyping techniques and allow the measurement of the unconstrained and independent movement of a large number of objects with an optical tracking system. Resulting structures have proven to work well in our experiments.
An efficient weighted Lp algorithm for the design of non-uniform filter banks

In this paper, we propose a simple weighted Lp algorithm for the design of non-uniform integer decimated filter banks. By choosing proper Lp criteria at pass-band and stop-band of the prototype filter and minimizing the p power of error function with an iterative method, ripples characteristic of the prototype filter can be efficiently controlled and non-uniform filter banks with high stop-band attenuation can be designed. An example is given to demonstrate the effectiveness of the proposed method.
Recent Improvements to Neural Network based Acoustic Modeling in the EML Transcription Platform

In recent years, automatic speech recognition has enjoyed tremendous improvements from the use of (deep) neural networks (DNNs) for both acoustic modeling and stochastic language modeling [1, 2]. Powerful hardware, in particular graphics processing units (GPUs), and sophisticated training algorithms enable the use of deeper and deeper networks that reduce word error rates achieved with conventional Gaussian Mixture Models (GMM/HMM) by up to 30 percent [3]. However, comparisons of latency and real time factor for conventional and DNN based speech recognizers are only seldom published.
Small RNA Based Genetic Engineering for Plant Viral Resistance: Application in Crop Protection

Small RNAs regulate a large set of gene expression in all plants and constitute a natural immunity against viruses. Small RNA based genetic engineering (SRGE) technology had been explored for crop protection against viruses for nearly 30 years. Viral resistance has been developed in diverse crops with SRGE technology and a few viral resistant crops have been approved for commercial release. In this review we summarized the efforts generating viral resistance with SRGE in different crops, analyzed the evolution of the technology, its efficacy in different crops for different viruses and its application status in different crops. The challenge and potential solution for application of SRGE in crop protection are also discussed.
Topology alteration for virtual sculpting using spatial deformation

Virtual sculpting enables the creation of computer models by emulating traditional sculpting. It can be implemented using spatial deformation, an interactive versatile modelling technique. Unfortunately, spatial deformation is limited to topology preserving warping. This is overcome by space-time objects, a variant of spatial deformation, which alters topology by extruding an object into 4-D, deforming the 4-D object and extracting a topologically altered object. However, they are specifically targeted to animation. In this paper, we adapt space-time objects to interactive modelling by: employing a tetrahedral rather than parallelepiped representation; exploiting coherence during the constant projection into four dimensions; and limiting projection to the portions of an object undergoing topology changes and thereby producing simpler triangulations of undeformed regions. Each of these adaptations is discussed in the context of the space-time object stages: extrusion, deformation and extraction. We also present preliminary results demonstrating the efficiency of our improvements.
Patients' views of low back pain and its management in general practice.

BACKGROUND Low back pain is a common and persistent problem. Research studies seeking to improve the quality of management of this condition have tended to ignore the opinions of patients. There is a growing acceptance of the importance of taking patients' views into account in developing management and educational programmes for a variety of conditions. AIM This study set out to elicit the views of patients concerning low back pain and its management in general practice. METHOD Fifty-two in-depth interviews were conducted with patients selected from a broad range of 12 general practices. RESULTS Analysis of the interviews identified seven themes relating to: quality of life, prognosis, secondary prevention, help-seeking behaviour, explanation of underlying pathology, satisfaction with general practitioner management, and complementary therapy. Different patient viewpoints or perspectives were expressed within each of these themes. Patients adapted to the progress of their low back pain and were not seeking a 'magical cure' from either conventional or complementary therapies. CONCLUSION Patients' views on low back pain are heterogeneous. The dissatisfaction expressed with medical explanations for the pain may be related to superficial clinical management and the constraints of general practice. Good management of low back pain needs to take patients' complex views of the condition into account.
THE USE OF ALLOGRAFT OR AUTOGRAFT AND EXPANDABLE TITANIUM CAGES FOR THE TREATMENT OF VERTEBRAL OSTEOMYELITIS

OBJECTIVEThe results of the surgical treatment of osteomyelitis with expandable titanium cages and either allograft or autograft are presented. METHODSThirty-six patients with vertebral osteomyelitis are presented. There were 7 cervical, 17 thoracic, 4 thoracolumbar (involving T12–L1), 5 lumbar, and 3 lumbosacral (involving L5–S1) lesions. The most frequently identified organisms were Staphylococcus aureus, Mycobacterium tuberculosis, and Coccidioides immitis. Imaging studies included x-rays, computed tomographic scans, and magnetic resonance imaging scans. All patients were treated with corpectomies and expandable cage reconstruction. Fusion was performed with rib autograft, iliac crest autograft, or allograft. Most patients who had an anterior approach also underwent posterior instrumentation, whereas a few had anterior instrumentation only. Four patients underwent a posterior approach (transpedicular corpectomy) only. RESULTSThe median follow-up period was 21 months. There were no implant failures. Two recurrences of infection were noted: 1 case involved allograft, and the other involved autograft. At follow-up, neurological deficits improved in all patients, and 81% of patients were pain-free. CONCLUSIONThis study suggests that the treatment of vertebral column osteomyelitis can be performed with expandable titanium cages, and allograft does not appear to increase the rate of recurrence, as compared with autograft.
Outcome of Solution-Focused Therapy at a University Family Therapy Center

This article reports results from a study of solution-focused brief therapy (N=83) conducted at the Universidad Pontificia de Salamanca (Spain). Outcome at follow-up was similar to that already reported in the literature: 82% of the clients stated that their problems were solved during therapy. On average, client scores on the scaling question increased 3 points (4.2 in the first to 7.2 in the last session), with 3 out of every 4 clients finishing at 7 or more on the scale. Mean number of sessions was 4.7 for the total sample (5.6 excluding dropouts), with almost 70% of the cases taking five or less interviews. Positive outcome at termination (but not at follow-up) was more likely for cases with “personal” complaints than for those with “relational” problems. A trend of favoring expert over trainee therapists in dropout rates was observed but did not reach statistical significance. Outcome at termination proved long lasting, correlating highly with outcome as measured at follow-up. Shortcomings of the stu.