Miracle-dz/UniFAR-FTUs huggingface dataset:
An Energy-efficient Multi-candidate Greedy Routing Scheme in Wireless Sensor Networks

Sleep and wake-up scheduling of sensor nodes is an efficient solution to prolong the network lifetime. However, existing scheduling algorithms may significantly decrease the number of active nodes so that the network may be intermittently-connected. In such networks, traditional geographic routing protocols are inappropriate to obtain low latency routes due to route discovery and data forwarding latency. In this paper, we propose a novel \emph{multi-candidate greedy routing} (MGR) scheme that makes the best effort to find minimum latency routes in the sensor networks. In MGR, each source node sends an RREQ to a set of first wake-up forwarder candidates and selects a route with minimum estimated delivery latency based on their replies. Moreover, to cope with the unreliability of wireless links, we introduce an add-on algorithm for MGR, called \emph{multilevel of link quality requirement-based packet forwarding} (MLRPF), which helps to increase the energy efficiency of MGR while still guaranteeing a low delivery latency. Simulation results demonstrate that MLRPF increases the routing performance of MGR significantly compared with PRRxDistance \cite{7}, DGF \cite{3}, and ODML \cite{2} in terms of packet delivery latency and energy efficiency.
Role of scapular stabilizers in etiology and treatment of impingement syndrome.

Shoulder pain and dysfunction with overhead activities resulting from subacromial impingement syndrome is common. A thorough history and physical examination are essential to identifying the etiology of the subacromial impingement syndrome and to direct treatment. Here, the lack of scapular stability is thought to contribute to secondary subacromial impingement syndrome. J Orthop Sports Phys Ther 1999;29(1):31–38. doi:10.2519/jospt.1999. 29.1. 31
Effects of sizes and shapes of props in tangible augmented reality

In this paper, we investigated the effect of relative difference between the virtual object and tangible prop in its size and shape in terms of usability. We have found the obvious fact that in general that manipulation is more efficient with equally sized/shaped prop and virtual objects. In addition, when decoupled, the size difference factor did not matter. While an additional experiment (in progress) is needed to confirm the true effect of shape difference, we posit that prop design should concentrate on representing the critical shape features for a given class of objects the prop is to represent. Humans are adept at recognizing and identifying objects even if there are shown at different scales and in different angles. This ability, called “constancy” is weaker in the dimension of shapes, e.g. compared to sizes, which is another reason to suspect shape to be a more critical factor for effective prop design. Another significant factor, in the design of props (not treated in this paper) is the prop to virtual object alignment (which can affect the task performance in terms of finding and feeling for a stable grasp). For instance, possible choices for spatially registering a prop to a virtual object (or vice versa) can be about their respective center of gravity, about the chosen surface, etc. Future experiments and prop design method will have to take this into account as well.
Identification of Quantitative Trait Loci Controlling Gene Expression during the Innate Immunity Response of Soybean1[W][OA]

Microbe-associated molecular pattern-triggered immunity (MTI) is an important component of the plant innate immunity response to invading pathogens. However, most of our knowledge of MTI comes from studies of model systems with relatively little work done with crop plants. In this work, we report on variation in both the microbe-associated molecular pattern-triggered oxidative burst and gene expression across four soybean (Glycine max) genotypes. Variation in MTI correlated with the level of pathogen resistance for each genotype. A quantitative trait locus analysis on these traits identified four loci that appeared to regulate gene expression during MTI in soybean. Likewise, we observed that both MTI variation and pathogen resistance were quantitatively inherited. The approach utilized in this study may have utility for identifying key resistance loci useful for developing improved soybean cultivars.
Improving Productivity in Citizen Science through Controlled Intervention

The majority of volunteers participating in citizen science projects perform only a few tasks each before leaving the system. We designed an intervention strategy to reduce disengagement in 16 different citizen science projects. Targeted users who had left the system received emails that directly addressed motivational factors that affect their engagement. Results show that participants receiving the emails were significantly more likely to return to productive activity when compared to a control group.
Épargne salariale : des pratiques différenciées selon les entreprises et les salariés

Encouragees par les pouvoirs publics, les entreprises developpent depuis plusieurs annees la participation et l’interessement ; ces deux formes d’epargne salariale restent inegalement reparties entre les salaries. Ainsi en 2002, 60 % des salaries ne recevaient ni interessement ni participation. Parmi les beneficiaires, les 10 % les mieux lotis se partageaient 40 % des sommes versees au titre de ces dispositifs. Le niveau hierarchique du salarie, le secteur d’activite et l’anciennete dans l’entreprise sont les facteurs conditionnant le plus l’acces a ces dispositifs et les montants percus. La taille de l’entreprise influence plus l’acces que les montants verses.
Distortion and Cost Controlled Video Streaming in a Heterogeneous Wireless Network Environment

With advances in variant wireless technologies, many mobile devices equipped with multiple interfaces have emerged. In such a multiple wireless network environment, it is desirable to enjoy streaming video with good quality and low cost. The challenge of providing such services is to take advantage of heterogeneous wireless network characteristics, including their bandwidth, packet lost probability and transmission cost. In this paper, we first present a detailed video distortion model to estimate the distortion experienced by service users. Based on this model, we then propose a 3-stage greedy algorithm, which determines the transmission sequences over two heterogeneous wireless networks, so that distortion controlled streaming video services can be provided with near-optimal cost. Experiment results show that the detailed video distortion model can keep the expected distortion under better control. Besides, the proposed 3-stage greedy algorithm provides a solution which meets the distortion and deadline constraints with the near-optimal cost
The effect of dimensions of transformational, transactional, and non-leadership on the job satisfaction and organizational commitment of teachers in Iran

It has been found that transformational and transactional leadership is positively related to the effectiveness of the leader, the subordinate’s effort, job satisfaction, and the subordinate’s organizational commitment. The purpose of this study is to examine the effect of transformational, transactional, and non-leadership on job satisfaction and organizational commitment. The population was teachers of all three levels of schooling (elementary, intermediate, and high school) in the province of Kermanshah, Iran in 2012–2013. The sample consisted of 387 teachers who were randomly selected from among 42 schools. The results seem to indicate that teachers experienced more value commitment than commitment to stay and job satisfaction. The results of the study revealed that charismatic leadership was a strong predictor of job satisfaction and value commitment, and laissez-faire leadership was a strong (negative) predictor of intent to stay.
Endogenous ecotropic mouse type C viruses deficient in replication and production of XC plaques

Endogenous ecotropic type C viruses were induced by iodedeoxyuridine from nontransformed and chemically or spontaneously transformed clones of the C3H/10T1/2 cell line. Viruses produced by cells of certain transformed clones were N-tropic and formed large XC plaques. In contrast, viruses produced by nontransformed C3H/10T1/2 cells were not detectable in the XC plaque test. These XC- viruses infected mouse cells with high efficiency, as shown by the induction of murine leukemia virus group-specific antigens in infected cells, but virus production, as determined by DNA polymerase-containing particles, was extremely low. Upon growth in certain mouse cells these replication-deficient, XC(-) viruses converted to type C viruses that were similar in XC assays to N-tropic AKR virus (XC+).
γ-H2AX Foci Formation as a Pharmacodynamic Marker of DNA Damage Produced by DNA Cross-Linking Agents: Results from 2 Phase I Clinical Trials of SJG-136 (SG2000)

Purpose: To evaluate γ-H2AX foci as a pharmacodynamic marker for DNA damage induced by DNA interstrand cross-linking drugs. Experimental Design: γ-H2AX foci formation was validated preclinically in comparison with the Comet assay, and evaluated pharmacodynamically in two phase I studies of different dosing schedules of the novel cross-linking agent SJG-136 (SG2000). Results: The measurement of γ-H2AX foci in human fibroblasts and lymphocytes in vitro was more than 10-fold more sensitive than Comet assay measurement of cross-linking, with peak γ-H2AX response 24 hours after the peak of cross-linking. In lymphocytes from a phase I study (every three week schedule), γ-H2AX foci were detectable 1 hour following the end of administration, and in all patients, maximum response was observed at 24 hours. Significant levels of foci were still evident at days 8 and 15 consistent with the known persistence of the DNA damage produced by this agent. In two tumor biopsy samples, foci were detected 4 hours postinfusion with levels higher than in lymphocytes. Extensive foci formation was also observed before the third dose in cycle 1 in lymphocytes from a second phase I study (daily × 3 schedule). These foci also persisted with a significant level evident before the second cycle (day 21). An increased γ-H2AX response was observed during the second cycle consistent with a cumulative pharmacodynamic effect. No clear relationship between foci formation and administered drug dose was observed. Conclusion: This is the first use of γ-H2AX as a pharmacodynamic response to a DNA cross-linking agent in a clinical trial setting. Clin Cancer Res; 19(3); 721–30. ©2012 AACR.
Requirement of CHROMOMETHYLASE3 for Maintenance of CpXpG Methylation

Epigenetic silenced alleles of the Arabidopsis SUPERMANlocus (the clark kent alleles) are associated with dense hypermethylation at noncanonical cytosines (CpXpG and asymmetric sites, where X = A, T, C, or G). A genetic screen for suppressors of a hypermethylated clark kent mutant identified nine loss-of-function alleles of CHROMOMETHYLASE3(CMT3), a novel cytosine methyltransferase homolog. These cmt3 mutants display a wild-type morphology but exhibit decreased CpXpG methylation of the SUP gene and of other sequences throughout the genome. They also show reactivated expression of endogenous retrotransposon sequences. These results show that a non-CpG DNA methyltransferase is responsible for maintaining epigenetic gene silencing.
Approximate inversion of the Preisach hysteresis operator with application to control of smart actuators

Hysteresis poses a challenge for control of smart actuators. A fundamental approach to hysteresis control is inverse compensation. For practical implementation, it is desirable for the input function generated via inversion to have regularity properties stronger than continuity. In this paper, we consider the problem of constructing right inverses for the Preisach model for hysteresis. Under mild conditions on the density function, we show the existence and weak-star continuity of the right-inverse, when the Preisach operator is considered to act on Holder continuous functions. Next, we introduce the concept of regularization to study the properties of approximate inverse schemes for the Preisach operator. Then, we present the fixed point and closest-match algorithms for approximately inverting the Preisach operator. The convergence and continuity properties of these two numerical schemes are studied. Finally, we present the results of an open-loop trajectory tracking experiment for a magnetostrictive actuator.
The Two ATP Binding Sites of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Play Distinct Roles in Gating Kinetics and Energetics

Cystic fibrosis transmembrane conductance regulator (CFTR), a member of the ABC (ATP binding cassette) transporter family, is a chloride channel whose activity is controlled by protein kinase–dependent phosphorylation. Opening and closing (gating) of the phosphorylated CFTR is coupled to ATP binding and hydrolysis at CFTR's two nucleotide binding domains (NBD1 and NBD2). Recent studies present evidence that the open channel conformation reflects a head-to-tail dimerization of CFTR's two NBDs as seen in the NBDs of other ABC transporters (Vergani et al., 2005). Whether these two ATP binding sites play an equivalent role in the dynamics of NBD dimerization, and thus in gating CFTR channels, remains unsettled. Based on the crystal structures of NBDs, sequence alignment, and homology modeling, we have identified two critical aromatic amino acids (W401 in NBD1 and Y1219 in NBD2) that coordinate the adenine ring of the bound ATP. Conversion of the W401 residue to glycine (W401G) has little effect on the sensitivity of the opening rate to [ATP], but the same mutation at the Y1219 residue dramatically lowers the apparent affinity for ATP by >50-fold, suggesting distinct roles of these two ATP binding sites in channel opening. The W401G mutation, however, shortens the open time constant. Energetic analysis of our data suggests that the free energy of ATP binding at NBD1, but not at NBD2, contributes significantly to the energetics of the open state. This kinetic and energetic asymmetry of CFTR's two NBDs suggests an asymmetric motion of the NBDs during channel gating. Opening of the channel is initiated by ATP binding at the NBD2 site, whereas separation of the NBD dimer at the NBD1 site constitutes the rate-limiting step in channel closing.
Beyond conventional wisdom: community cultural wealth and the college knowledge of African American youth in the United States

Abstract African American youth are generally as likely as their peers from other racial and ethnic groups to aspire to earn a college degree; yet, in spite of their aspirations these students remain under-represented in college enrollment and graduation. Part of the disparity between these students’ aspirations and the realization of their goals may lie in their minimal college knowledge and nominal participation in postsecondary preparatory activities that have frequently been caused by the historic, and ongoing, systematic disenfranchisement of African Americans. During interviews, college students reflected on how similarly-aged family members, peers, co-workers, and parishioners assisted with various aspects of college preparation and enrollment. The community cultural wealth framework helps us understand the reason for, and importance of, this ‘lateral mentorship’ in the fulfillment of these students’ college aspirations. Consequently, educators and educational systems are challenged to be more responsive to the college preparatory needs of traditionally under-represented college-going populations.
"VRA-GlcNAc": novel substrate for N-acetyl-beta-D-glucosaminidase applied to assay of this enzyme in urine.

We describe a new chromogenic substrate and assay for determining N-acetyl-beta-D-glucosaminidase (EC 3.2.1.30; NAG) activity in normal and pathological human urine. The novel substrate, ammonium 5-[4-(2-acetamido-2-deoxy-beta-D-glucopyranosyloxy)-3- methoxyphenylmethylene]-2-thioxothiazolidin-4-one-3-ethan oate (VRA-GlcNAc), is prepared by condensation of vanillyl N-acetyl-beta-D-glucosaminide and rhodanine-3-ethanoic acid. The phenol released by enzyme action has an intense absorption peak at 492 nm (epsilon = 37,000 L.mol-1.cm-1). The Km for NAG in urine was 0.5 mmol/L at pH 4.5. The substrate solution may be stored at 4-7 degrees C for one week without any increase in the substrate blank. For optimal assay conditions, we used a substrate concentration of 3 mmol/L and a 15-fold sample dilution at pH 4.5-5.0, with measurement at 505 nm, not significantly different from that at 492 nm. The sensitivity of the assay with VRA-GlcNAc as substrate is twice that of the MNP-GlcNAc [2-methoxy-4-(2'-nitrovinyl)-phenyl GlcNAc] procedure (Clin Chim Acta 1982;124:195-204) and can detect low amounts of minor NAG isoenzymes. This assay is an improvement on previously available colorimetric methods and could be easily incorporated into kits based on either an enzyme calibrant or the molar absorptivity of the phenol.
Preservation of donor hearts using hypothermic oxygenated perfusion.

BACKGROUND Hypothermic machine perfusion of donor hearts enables continuous aerobic metabolism and washout of toxic metabolic byproducts. We evaluated the effect of machine perfusion on cardiac myocyte integrity in hearts preserved for 4 h in a novel device that provides pulsatile oxygenated hypothermic perfusion (Paragonix Sherpa Perfusion™ Cardiac Transport System). MATERIAL AND METHODS Pig hearts were harvested and stored in Celsior® solution for 4 h using either conventional cold storage on ice (4-h CS, n=6) or the Sherpa device (4-h pulsatile perfusion (PP), n=6). After cold preservation, hearts were evaluated using a non-working heart Langendorff system. Controls (n=3) were reperfused immediately after organ harvest. Biopsies were taken from the apex of the left ventricle before storage, after storage, and after reperfusion to measure ATP content and endothelin-1 in the tissue. Ultrastructural analysis using electron microscopy was performed. RESULTS Four-hour CS, 4-h PP, and control group did not show any significant differences in systolic or diastolic function (+dP/dt, -dP/dt, EDP). Four-hour PP hearts showed significantly more weight gain than 4-h CS after preservation, which shows that machine perfusion led to myocardial edema. Four-hour CS led to higher endothelin-1 levels after preservation, suggesting more endothelial dysfunction compared to 4-h PP. Electron microscopy revealed endothelial cell rupture and damaged muscle fibers in the 4-h CS group after reperfusion, but the cell structures were preserved in the 4-h PP group. CONCLUSIONS Hypothermic pulsatile perfusion of donor hearts leads to a better-preserved cell structure compared to the conventional cold storage method. This may lead to less risk of primary graft failure after orthotopic heart transplantation.
Some remarks on multiplicity codes

Multiplicity codes are algebraic error-correcting codes generalizing classical polynomial evaluation codes, and are based on evaluating polynomials and their derivatives. This small augmentation confers upon them better local decoding, list-decoding and local list-decoding algorithms than their classical counterparts. We survey what is known about these codes, present some variations and improvements, and finally list some interesting open problems.
Nonparametric Imputation of Missing Values for Estimating Equation Based Inference

We consider an empirical likelihood inference for parameters defined by general estimating equations when some components of the random observations are subject to missingness. As the nature of the estimating equations is wide ranging, we propose a nonparametric imputation of the missing values from a kernel estimator of the conditional distribution of the missing variable given the always observable variable. The empirical likelihood is used to construct a profile likelihood for the parameter of interest. We demonstrate that the proposed nonparametric imputation can remove the selection bias in the missingness and the empirical likelihood leads to more efficient parameter estimation. The proposed method is further evaluated by simulation and an empirical study on a genetic dataset on recombinant inbred mice.
Marginal zone B-cell lymphoma: A clinical comparison of nodal and mucosa-associated lymphoid tissue types. Non-Hodgkin's Lymphoma Classification Project.

PURPOSE In the International Lymphoma Study Group classification of lymphoma, extranodal marginal zone B-cell lymphoma (MZL) of mucosa-associated lymphoid tissue (MALT) type is listed as a distinctive entity. However, nodal MZL is listed as a provisional entity because of questions as to whether it is truly a disease or just an advanced stage of MALT-type MZL. To resolve the issue of whether primary nodal MZL without involvement of mucosal sites exists and whether it is clinically different from extranodal MALT-type lymphoma, we compared the clinical features of these two lymphomas. PATIENTS AND METHODS Five expert hematopathologists reached a consensus diagnosis of MZL in 93 patients. Seventy-three were classified as having MALT-type MZL because of involvement of a mucosal site at the time of diagnosis, and 20 were classified as having nodal MZL because of involvement of lymph nodes without involvement of a mucosal site. RESULTS A comparison of the clinical features of nodal MZL and MALT-type MZL showed that more patients with nodal MZL presented with advanced-stage disease (71% v 34%; P =. 02), peripheral lymphadenopathy (100% v 8%; P <.001), and para-aortic lymphadenopathy (56% v 14%; P <.001) than those with MALT-type MZL. However, fewer patients with nodal MZL had a large mass (> or = 5 cm) than those with MALT-type MZL (31% v 68%; P =.03). The 5-year overall survival of patients with nodal MZL was lower than that for patients with MALT-type MZL (56% v 81%; P =.09), with a similar result for failure-free survival (28% v 65%; P =.01). Comparisons of patients with International Prognostic Index scores of 0 to 3 showed that those with nodal MZL had lower 5-year overall survival (52% v 88%; P =.025) and failure-free survival (30% v 75%; P =.007) rates than those with MALT-type MZL. CONCLUSION Nodal MZL seems to be a distinctive disease entity rather than an advanced stage of MALT-type MZL because the clinical presentations and survival outcomes are different in these two types of MZL. Clinically, nodal MZL is similar to other low-grade, node-based B-cell lymphomas, such as follicular and small lymphocytic lymphomas.
Form equals function? Bacterial shape and its consequences for pathogenesis

Bacteria exhibit a wide variety of morphologies. This could simply be a consequence of an elaboration of bacterial cellular architecture akin to the famous decorative but not structurally essential Spandrels in the Basilica di San Marco in Venice that are a side‐effect of an adaptation, rather than a direct product of natural selection. However, it is more likely that particular morphologies facilitate a specific function in cellular physiology. Two recent publications including one in this issue of Molecular Microbiology and another in Cell provide new insights into the molecular basis for the helical shape of the bacterium Helicobacter pylori and the role of this shape in pathogenesis. They identify a novel endopeptidase that is necessary to generate the helical shape by processing the peptidoglycan and report that catalytically inactive mutants lead to defects in colonization that appear to be independent of an effect on cellular motility. Here, we put these findings in the context of some of what is known about peptidoglycan and cell shape and suggest that the role of this endopeptidase in forming coccoid morphology may be critical for pathogenesis.