Miracle-dz/UniFAR-FTUs huggingface dataset:
University Ofhawaìi at Mānoa Department of Economics Working Paper Series Why Does Real-time Information Reduce Energy Consumption? Why Does Real-time Information Reduce Energy Consumption?

A number of studies have estimated how much energy conservation is achieved by providing households with real-time information on energy use via in-home displays. However, none of these studies tell us why real-time information changes energy-use behavior. We explore the causal mechanisms through which real-time information affects energy consumption by conducting a randomized-control trial with residential households. The experiment disentangles two competing mechanisms: (i) learning about the energy consumption of various activities, the " learning effect " , versus (ii) having a constant reminder of energy use, the " saliency effect ". We have two main results. First, we find a statistically significant treatment effect from receiving real-time information. Second, we find that learning plays a more prominent role than saliency in driving energy conservation. This finding supports the use of energy conservation programs that target consumer knowledge regarding energy use.
[The Italian Survey on Cardiac Rehabilitation - 2013 (ISYDE.13-Directory): national availability and organization of cardiac rehabilitation facilities].

BACKGROUND The Italian Association for Cardiovascular Prevention, Rehabilitation and Epidemiology (GICR-IACPR) and the Italian Society of Cardiologists of Accredited Hospitals (SICOA) developed the ISYDE.13 survey with the purpose to take a detailed snapshot of number, distribution, facilities, staffing levels, organization, and program details of cardiac rehabilitation (CR) units in Italy. METHODS The study was carried out using a web-based questionnaire running on the GICR-IACPR website for 4 weeks from September 2 to 29, 2013. RESULTS Out of 221 CR centers existing in Italy (+14% vs 2008), 191 (86%) participated in the survey. On a national basis, there is a CR unit every 268 852 inhabitants. The majority of CR units are located in public hospitals (57.1%), the remaining 42.9% in private hospitals; 130 CR centers (68%) provide inpatients care and account for 3527 beds (5.9 per 100 000 inhabitants): of these 374 are day-hospital beds and 408 are sub-intensive beds. Forty-one of the Italian in-hospital CR centers offer also outpatient programs and 61 centers (32%) offer only outpatient CR programs; 131 of the CR units (68.6%) are linked to dedicated cardiology divisions and in 77% of cases the head is a cardiologist. Home-based programs are offered by 9 centers (4.7%) and CR programs with telecare supervision by 16 (8.4%). Long-term secondary prevention follow-up programs are provided by 94 of CR services (49.2%). During one week of activity, the 191 centers completed 1335 inpatient CR programs and 971 outpatient CR programs. According to these data, it may be assumed that in Italy approximately 100 000 patients are referred annually to CR programs. CONCLUSIONS ISYDE.13 showed an incremental trend of CR provision in Italy, particularly in outpatient programs. However, at present, the national network of CR units covers only one third of the potential requirements defined by current secondary prevention recommendations.
Bee Inspired Novel Optimization Algorithm and Mathematical Model for Effective and Efficient Route Planning in Railway System

Railway and metro transport systems (RS) are becoming one of the popular choices of transportation among people, especially those who live in urban cities. Urbanization and increasing population due to rapid development of economy in many cities are leading to a bigger demand for urban rail transit. Despite being a popular variant of Traveling Salesman Problem (TSP), it appears that the universal formula or techniques to solve the problem are yet to be found. This paper aims to develop an optimization algorithm for optimum route selection to multiple destinations in RS before returning to the starting point. Bee foraging behaviour is examined to generate a reliable algorithm in railway TSP. The algorithm is then verified by comparing the results with the exact solutions in 10 test cases, and a numerical case study is designed to demonstrate the application with large size sample. It is tested to be efficient and effective in railway route planning as the tour can be completed within a certain period of time by using minimal resources. The findings further support the reliability of the algorithm and capability to solve the problems with different complexity. This algorithm can be used as a method to assist business practitioners making better decision in route planning.
Computer Simulation of the Pattern Formation of a Spatial Ecosystem

In this paper, we analyze the spatial pattern of a predator-prey system. We get the critical line of Hopf and Turing bifurcation in a spatial domain. Via computer simulation, we study how diffusion affects the stability of predator-prey coexistence equilibrium and give the spatial pattern formation, the evolution process of the system near the coexistence equilibrium point. Our results show that modeling by reaction-diffusion equations is an appropriate tool for investigating fundamental mechanisms of complex spatiotemporal dynamics.
Structures and Ribosomal Interaction of Ribosome-Inactivating Proteins

Ribosome-inactivating proteins (RIPs) including ricin, Shiga toxin, and trichosanthin, are RNA N-glycosidases that depurinate a specific adenine residue (A-4324 in rat 28S ribosomal RNA, rRNA) in the conserved α-sarcin/ricin loop (α-SRL) of rRNA. RIPs are grouped into three types according to the number of subunits and the organization of the precursor sequences. RIPs are two-domain proteins, with the active site located in the cleft between the N- and C-terminal domains. It has been found that the basic surface residues of the RIPs promote rapid and specific targeting to the ribosome and a number of RIPs have been shown to interact with the C-terminal regions of the P proteins of the ribosome. At present, the structural basis for the interaction of trichosanthin and ricin-A chain toward P2 peptide is known. This review surveys the structural features of the representative RIPs and discusses how they approach and interact with the ribosome.
Human NOD2 Recognizes Structurally Unique Muramyl Dipeptides from Mycobacterium leprae

ABSTRACT The innate immune system recognizes microbial pathogens via pattern recognition receptors. One such receptor, NOD2, via recognition of muramyl dipeptide (MDP), triggers a distinct network of innate immune responses, including the production of interleukin-32 (IL-32), which leads to the differentiation of monocytes into dendritic cells (DC). NOD2 has been implicated in the pathogenesis of human leprosy, yet it is not clear whether Mycobacterium leprae, which has a distinct MDP structure, can activate this pathway. We investigated the effect of MDP structure on the innate immune response, finding that infection of monocytes with M. leprae induces IL-32 and DC differentiation in a NOD2-dependent manner. The presence of the proximal l-Ala instead of Gly in the common configuration of the peptide side chain of M. leprae did not affect recognition by NOD2 or cytokine production. Furthermore, amidation of the d-Glu residue did not alter NOD2 activation. These data provide experimental evidence that NOD2 recognizes naturally occurring structural variants of MDP.
Electron-impact rotational excitation of CH+

New coupled-state R-matrix calculations are performed at energies up to 1 eV to give rotational excitation and de-excitation cross-sections for electron collisions with CH+. Rotational excitations with Delta j up to 7 are considered. Transitions with Delta j up to 6 are found to have appreciable cross-sections, those with Delta j = 2 being comparable to (indeed slightly larger than) those with Delta j = 1, the only ones considered previously. Rates for electron temperatures up to 15 000K and critical electron densities are given. A model of CH+ rotational populations shows them to be relatively insensitive to electron temperatures in the range 800-2000K, but to depend strongly upon electron density. The models predict a significant population in rotational states with j > 1 even at low electron densities; at higher densities the possibility exists that electron collisions alone might explain the recently observed populations in the planetary nebula NGC 7027.
Bio-inspired Underwater Robot with Reconfigurable and Detachable Swimming Modules

Maneuverability and propulsive efficiency are of much interest in autonomous underwater robots. In this paper, we present a novel underwater robot design with two reconfigurable and detachable swimming modules that would be capable of offering both maneuverability and propulsive efficiency. They are also capable of reconfiguring automatically to take two different orientations favoring reduced drag in the swimming direction. A key feature of this design is that the reconfigurability is achieved without additional actuators - helpful in the development of autonomous swarm robots with good maneuverability and efficiency.
Affine braid group actions on derived categories of Springer resolutions

In this paper we construct and study an action of the affine braid group associated to a semi-simple algebraic group on derived categories of coherent sheaves on various varieties related to the Springer resolution of the nilpotent cone. In particular, we describe explicitly the action of the Artin braid group. This action is a "categorical version" of Kazhdan--Lusztig--Ginzburg's construction of the affine Hecke algebra, and is used in particular by the first author and Ivan Mirkovic in the course of the proof of Lusztig's conjectures on equivariant K-theory of Springer fibers.
Author's paper Similarity Prediction based on the Similarity of Textual References to Visual Features

In this paper we introduce a mechanism to find similar papers of an author, based on the author's previous1 publications. In other words, since the author(s) of a paper are more likely to publish similar work(s) to their paper, we use this intuition to seek related papers based on the visual similarity of those papers. The visuality here is the figures and or tables that are commonly used by authors to describe their method structure and/or the result of their experiments. Since similar works of authors are focused on solving similar problems as well as developing and improving similar techniques, we noticed that comparing these visual features among their publications would help to spot most similar papers of those authors. We call our method, Similarity of Textual References to Visual Features which means, we compare parts of content of any two arbitrary papers that have references to any figures and/or tables. In our experiment we show that how we can use this similarity together with other factors of a paper to form a Boolean function which helps to build an indexation for papers based on the number of their authors. In this way, we omit time consuming process of papers' content determined analysis, such as, textual content analysis, building coauthor network, citation network etc. In addition, our Boolean function has the ability of adjusting level of Sensitivity. If we want to achieve higher accuracy of similar papers, the Boolean function needs to be enabled for more2 conditions.
Nuclear Receptor Expression and Function in Human Lung Cancer Pathogenesis

Lung cancer is caused by combinations of diverse genetic mutations. Here, to understand the relevance of nuclear receptors (NRs) in the oncogene-associated lung cancer pathogenesis, we investigated the expression profile of the entire 48 NR members by using QPCR analysis in a panel of human bronchial epithelial cells (HBECs) that included precancerous and tumorigenic HBECs harboring oncogenic K-rasV12 and/or p53 alterations. The analysis of the profile revealed that oncogenic alterations accompanied transcriptional changes in the expression of 19 NRs in precancerous HBECs and 15 NRs according to the malignant progression of HBECs. Amongst these, peroxisome proliferator-activated receptor gamma (PPARγ), a NR chosen as a proof-of-principle study, showed increased expression in precancerous HBECs, which was surprisingly reversed when these HBECs acquired full in vivo tumorigenicity. Notably, PPARγ activation by thiazolidinedione (TZD) treatment reversed the increased expression of pro-inflammatory cyclooxygenase 2 (COX2) in precancerous HBECs. In fully tumorigenic HBECs with inducible expression of PPARγ, TZD treatments inhibited tumor cell growth, clonogenecity, and cell migration in a PPARγ-sumoylation dependent manner. Mechanistically, the sumoylation of liganded-PPARγ decreased COX2 expression and increased 15-hydroxyprostaglandin dehydrogenase expression. This suggests that ligand-mediated sumoylation of PPARγ plays an important role in lung cancer pathogenesis by modulating prostaglandin metabolism.
Risk of treatment related death and febrile neutropaenia with taxane-based adjuvant chemotherapy for breast cancer in a middle income country outside a clinical trial setting.

BACKGROUND The risk of treatment-related death (TRD) and febrile neutropaenia (FN) with adjuvant taxane- based chemotherapy for early breast cancer is unknown in Malaysia despite its widespread usage in recent years. This study aims to determine these rates in patients treated in University Malaya Medical Centre (UMMC). PATIENTS AND METHODS Patients who were treated with adjuvant taxane-based chemotherapy for early breast cancer stages I, II or III from 2007-2011 in UMMC were identified from our UMMC Breast Cancer Registry. The TRD and FN rates were then determined retrospectively from medical records. TRD was defined as death occurring during or within 30 days of completing chemotherapy as a consequence of the chemotherapy treatment. FN was defined as an oral temperature >38.5°C or two consecutive readings of >38.0°C for 2 hours and an absolute neutrophil count <0.5x109/L, or expected to fall below 0.5x109/L. RESULTS A total of 622 patients received adjuvant chemotherapy during this period. Of these patients 209 (33.6%) received taxane-based chemotherapy. 4 taxane-based regimens were used namely the FEC-D, TC, TAC and AC-PCX regimens. The commonest regimen employed was the FEC-D regimen accounting for 79.9% of the patients. The FN rate was 10% and there was no TRD. CONCLUSION Adjuvant taxane-based chemotherapy in UMMC for early breast cancer has a FN rate of 10%. Primary prophylactic G-CSF should be considered for patients with any additional risk factor for FN.
On the validity of peer grading and a cloud teaching assistant system

We introduce a new grading system, the Cloud Teaching Assistant System (CTAS), as an additional element to instructor grading, peer grading and automated validation in massive open online courses (MOOCs). The grading distributions of the different approaches are compared in an experiment consisting of 476 exam participants. 25 submissions were graded by all four methods. 451 submissions were graded only by peer grading and automated validation. The results of the experiment suggest that both CTAS and peer grading do not simulate instructor grading (Pearson's correlations: 0.36, 0.39). If the CTAS and not the instructor is assumed to deliver accurate grading, peer grading is concluded to be a valid grading method (Pearson's correlation: 0.76).
Test-point insertion efficiency analysis for LBIST applications

Test points are inserted into integrated circuits to increase fault coverage especially in logic built-in self-test (LBIST) schemes. Commercial tools have been developed over the past decade to insert test points in circuits under test, but they are often inefficient and incur unacceptably large area overhead. Our analysis shows that many test points have little or no impact on test coverage. Therefore, we propose a framework to evaluate test point's impact on a design and rank them based on their efficiency, and to obtain an optimal configuration of the most efficient test points accurately and rapidly. Within this framework, we have two metrics; namely the efficient test point insertion (ETPI) metric and the test point removal estimation (TPRE) metric. The ETPI metric is developed to remove the most inefficient test points inserted in the circuits by the commercial tools, thereby minimizing area penalty with very limited test coverage loss. The TPRE metric is introduced to quickly select the appropriate test point removal scheme. Since TPRE can estimate area overhead and test coverage for designs with different percentage of test points removed without the actual insertion of test points and without the need for lengthy circuit simulation, large amount of processing time is saved especially for large circuits. Experimental results indicate that ETPI can reduce area overhead reduction by up to 95.00% with test coverage reduction as low as 0.57%. In addition, results by applying the TPRE metric indicate that the difference between estimation and actual simulation/synthesis results for area overhead is less than 0.10% for most cases, and the difference between them for test coverage is less than 1.00% for most cases.
WHY DOES PROACTIVE PERSONALITY PREDICT EMPLOYEE LIFE SATISFACTION AND WORK BEHAVIORS? A FIELD INVESTIGATION OF THE MEDIATING ROLE OF THE SELF‐CONCORDANCE MODEL

We integrated the proactive personality and the self-concordance model literatures to hypothesize and test a model that explicates the processes through which proactive personality relates to employee life satisfaction, in-role performance, and organizational citizenship behaviors (OCBs). Across 3 time periods, data were collected from 165 employees and their supervisors. Results indicated that more proactive individuals were more likely to set self-concordant goals and attain their goals, which in turn predicted psychological need satisfaction. Psychological need satisfaction subsequently predicted employee life satisfaction, in-role performance, and OCBs. Further, goal attainment directly predicted employee life satisfaction. Our results also indicated that proactive personality's relations with employee life satisfaction, in-role performance, and OCBs were entirely indirect through goal self-concordance, goal attainment, and psychological need satisfaction.
The Good, the Bad, and the Borderline: Separating Teasing from Bullying

In recent years, the research on teasing and bullying has grown dramatically and is coupled with a rise in the development of intervention programs targeted to teachers, principals, and parents. Ultimately the goal of these programs is to reduce or eliminate teasing and bullying within school settings. The aim of this project is to clarify how teasing and bullying are interrelated, but can be two very distinct acts with different motivations, goals, and outcomes, in order to provide researchers and educators with a better grasp of the differences between the two. To accomplish these goals, this paper examines the definitions and research on bullying. Next, teasing is described, analyzed and contrasted with bullying to provide educators a way to differentiate between the two different behaviors. Finally, this work seeks to provide educators with pragmatic considerations to assist them in identifying the differences between bullying and teasing behaviors so that any intervention program chosen for their educational setting can provide the desired result of reducing negative outcomes associated with bullying or antisocial teasing.
Aero-Marker: blimp-based augmented reality marker for objects with virtual and tangible features

In this study, we describe an augmented reality (AR) marker---Aero-Marker---that has both a virtual appearance and physical features. Our Aero-Marker integrates a blimp with an AR marker to overcome two problems found in conventional AR applications. The first problem is mobility. While a conventional AR marker is generally paper-based and static, Aero-Marker floats in the air and moves toward the user, thereby changing the relationship between the user and the marker. The second problem is physicality. Unlike a paper-based marker, Aero-Marker has physical volume because it uses a physical blimp. Similar to texture mapping in 3D computer graphics, virtual information is overlaid on the entire surface of the blimp, which makes the virtual information tangible. As a result, the interaction between the user and marker intensifies during actions like hugging, lifting, and throwing virtual information directly.
As quatro faces de RH: analisando a performance da gestão de Recursos Humanos em empresas no Brasil

This paper aims to analyze Brazilian companies' Human Resource Management [HRM] performance. We used the Four Faces of the HRM model developed by Tanure, Evans and Pucik (2007) as a framework. The four faces are: executor, constructor, change partner and navigator. To achieve our goal, we discussed the result of a survey with 172 presidents of the 500 biggest companies in Brazil. We also analyzed a case study of a finance company - Brasilprev. The data was collected during 14 interviews, from three focal groups with 15 collaborators from all the hierarchical levels and 68 questionnaires. The results of the presidents' survey showed that the HRM is mainly considered as an executor in Brazilian capital companies. The constructor and the change partner faces prevail in multinational capital companies. According to the case study results, the HRM of Brasilprev is moving to the change partner face. Nevertheless, even if a company's HR practices are modern and sophisticated, they do not present internal or external consistency. Therefore, we can conclude that the executor face still prevails in Brazilian companies, although modern HRM practices are utilized.
Transsynaptic channelosomes

Recent findings demonstrate that synaptic channels are directly involved in the formation and maintenance of synapses by interacting with synapse organizers. The synaptic channels on the pre- and postsynaptic membranes possess non-conducting roles in addition to their functional roles as ion-conducting channels required for synaptic transmission. For example, presynaptic voltage-dependent calcium channels link the target-derived synapse organizer laminin β2 to cytomatrix of the active zone and function as scaffolding proteins to organize the presynaptic active zones. Furthermore, postsynaptic δ2-type glutamate receptors organize the synapses by forming transsynaptic protein complexes with presynaptic neurexins through synapse organizer cerebellin 1 precursor proteins. Interestingly, the synaptic clustering of AMPA receptors is regulated by neuronal activity-regulated pentraxins, while postsynaptic differentiation is induced by the interaction of postsynaptic calcium channels and thrombospondins. This review will focus on the non-conducting functions of ion-channels that contribute to the synapse formation in concert with synapse organizers and active-zone-specific proteins.