Miracle-dz/UniFAR-FTUs huggingface dataset:
The Influence of Gun Availability on Violent Crime Patterns

The spectacular increases in violent crime that began in the mid-1960s continue, and Americans are currently being murdered, robbed, and raped at historically unprecedented rates. Firearms are used in a minority of violent crimes but are of special concern because more than 60 percent of the most serious crimes-criminal homicides-are committed with firearms. This essay presents a variety of evidence to the effect that the widespread availability of firearms contributes to the criminal homicide rate and influences violent crime patterns in several other respects as well. A gun is usually superior to other weapons readily available for use in violent crime; even in the hands of a weak and unskilled assailant, a gun poses a credible threat and can be used to kill quickly, from a distance, and in a relatively "impersonal" fashion. Guns are particularly valuable against relatively invulnerable targets. Hence, gun availability facilitates robbery of commercial places and lethal assaults on people who would ordinarily be able to defend themselves against other weapons. Some of the patterns of gun use in violent crime can be readily interpreted in terms of relative vulnerability of different types of victims. Guns are also more dangerous than other weapons, in the sense that victims of robbery and assault are more likely to be killed if the assailant uses a gun. On the other hand, the victim is less likely to be injured in a gun robbery than in other robberies, since the gun robber usually does not feel the need to employ physical force. This analysis suggests a number of predictions concerning the effects of gun availability on the number, distribution, and seriousness of violent crimes. In principle, these predictions could be tested directly by observing the effects of changes in gun availability on statistical characterizations of violent crime patterns. Not much research of this sort has been done, in part because it is difficult to find a suitable measure for gun availability. Future research should be directed toward remedying this problem. In the meantime, it seems fair to conclude from the available evidence that the type of weapon is not an incidental aspect of violent crime, but rather has a substantial influence on the nature of the encounter and its likely consequences.
Dynamic benefit-weighted scheduling scheme in multi service networks

This paper proposes a new dynamic packet scheduling scheme which guarantees the delay and jitter properties of differentiated services (DiffServ) network for both real time and non-real time traffics. The proposed dynamic packet scheduling algorithm uses a new weighted computation scheme known as dynamic benefit weighted scheduling (DB-WS) which is loosely based on weighted round robin (WRR) or fair queuing policy. The novelty of this scheduler is that it predicts the weight required by expedited forwarding (EF) service for current time slot (t) based on two factors: (i) previous weight allocated to it at time slot (t-1), and (ii) average increase in weights of EF traffic in consecutive time slots. This prediction provides smoother and balanced bandwidth allocation to EF, assured forwarding (AF) and best effort (BE) packets by not allocating all the resources to EF and also ensuring minimal packet losses for EF service. Adopting such a dynamic resource allocation effectively achieves reduction in packet loss, end to end delay and delay jitter. The algorithm is tested with different data rates and found to outperform other existing methods in terms of packet loss and end to end delay.
DipA, a Pore-Forming Protein in the Outer Membrane of Lyme Disease Spirochetes Exhibits Specificity for the Permeation of Dicarboxylates

Lyme disease Borreliae are highly dependent on the uptake of nutrients provided by their hosts. Our study describes the identification of a 36 kDa protein that functions as putative dicarboxylate-specific porin in the outer membrane of Lyme disease Borrelia. The protein was purified by hydroxyapatite chromatography from Borrelia burgdorferi B31 and designated as DipA, for dicarboxylate-specific porin A. DipA was partially sequenced, and corresponding genes were identified in the genomes of B. burgdorferi B31, Borrelia garinii PBi and Borrelia afzelii PKo. DipA exhibits high homology to the Oms38 porins of relapsing fever Borreliae. B. burgdorferi DipA was characterized using the black lipid bilayer assay. The protein has a single-channel conductance of 50 pS in 1 M KCl, is slightly selective for anions with a permeability ratio for cations over anions of 0.57 in KCl and is not voltage-dependent. The channel could be partly blocked by different di- and tricarboxylic anions. Particular high stability constants up to about 28,000 l/mol (in 0.1 M KCl) were obtained among the 11 tested anions for oxaloacetate, 2-oxoglutarate and citrate. The results imply that DipA forms a porin specific for dicarboxylates which may play an important role for the uptake of specific nutrients in different Borrelia species.
Anticancer and Immunogenic Properties of Cardiac Glycosides

Cardiac glycosides (CGs) are natural compounds widely used in the treatment of several cardiac conditions and more recently have been recognized as potential antitumor compounds. They are known to be ligands for Na/K-ATPase, which is a promising drug target in cancer. More recently, in addition to their antitumor effects, it has been suggested that CGs activate tumor-specific immune responses. This review summarizes the anticancer aspects of CGs as new strategies for immunotherapy and drug repositioning (new horizons for old players), and the possible new targets for CGs in cancer cells.
Rates of morphological evolution are heterogeneous in Early Cretaceous birds

The Early Cretaceous is a critical interval in the early history of birds. Exceptional fossils indicate that important evolutionary novelties such as a pygostyle and a keeled sternum had already arisen in Early Cretaceous taxa, bridging much of the morphological gap between Archaeopteryx and crown birds. However, detailed features of basal bird evolution remain obscure because of both the small sample of fossil taxa previously considered and a lack of quantitative studies assessing rates of morphological evolution. Here we apply a recently available phylogenetic method and associated sensitivity tests to a large data matrix of morphological characters to quantify rates of morphological evolution in Early Cretaceous birds. Our results reveal that although rates were highly heterogeneous between different Early Cretaceous avian lineages, consistent patterns of significantly high or low rates were harder to pinpoint. Nevertheless, evidence for accelerated evolutionary rates is strongest at the point when Ornithuromorpha (the clade comprises all extant birds and descendants from their most recent common ancestors) split from Enantiornithes (a diverse clade that went extinct at the end-Cretaceous), consistent with the hypothesis that this key split opened up new niches and ultimately led to greater diversity for these two dominant clades of Mesozoic birds.
Bifidobacterium and Lactobacillus DNA in the human placenta

Aims: Bifidobacteria and lactobacilli are part of the human normal intestinal microbiota and may possibly be transferred to the placenta. It was hypothesized that intestinal bacteria or their components are present in the placenta and that the foetus may be exposed to them. We investigated the presence of bifidobacteria and lactobacilli and their DNA in the human placenta.
Performance analysis of NoC structure based on Star-Mesh Topology

The fabrication technology development of the semiconductor leads the evolutional design methodology to reconsider the efficiency, such as reusability and scalability. NoC (Network On Chip) is the remarkable alternative to support this trend that provides the interface between IPs. In this paper, the general performance analysis through considering the characteristic of the NoC was done with the proposed NoC topology. Besides, the performance at the topology which is the specification application, 4-channel H.264 decoder, was predicted in advance. We could build the environment facilitating the adjustment of the buffer size and mapping of IP with this scheme.
Serodiagnostic Potential of Culture Filtrate Antigens of Mycobacterium tuberculosis

ABSTRACT Our studies of the humoral responses of tuberculosis (TB) patients have defined the repertoire of culture filtrate antigens ofMycobacterium tuberculosis that are recognized by antibodies from cavitary and noncavitary TB patients and demonstrated that the profile of antigens recognized changes with disease progression (K. Samanich et al., J. Infect. Dis. 178:1534–1538, 1998). We have identified several antigens with strong serodiagnostic potential. In the present study we have evaluated the reactivity of cohorts of human immunodeficiency virus (HIV)-negative, smear-positive; HIV-negative, smear-negative; and HIV-infected TB patients, with three of the candidate antigens, an 88-kDa protein, antigen (Ag) 85C, and MPT32, and compared the reactivity of the same patient cohort with the 38-kDa antigen and Ag 85A. We have also compared the reactivity of native Ag 85C and MPT32 with their recombinant counterparts. The evaluation of the reactivity was done by a modified enzyme-linked immunosorbent assay described earlier (S. Laal et al., Clin. Diag. Lab. Immunol. 4:49–56, 1997), in which all sera are preadsorbed againstEscherichia coli lysates to reduce the levels of cross-reactive antibodies. Our results demonstrate that (i) antigens identified on the basis of their reactivity with TB patients' sera provide high sensitivities for serodiagnosis, (ii) recombinant Ag 85C and MPT32, expressed in E. coli, show reduced reactivity with human TB sera, and (iii) of the panel of antigens tested, the 88-kDa protein is the most promising candidate for serodiagnosis of TB in HIV-infected individuals. Moreover, these results reaffirm that both the extent of the disease and the bacterial load may play a role in determining the antigen profile recognized by antibodies.
KfW and the Promotion of Entrepreneurship Training in Germany.

The author, a spokesperson for Kreditanstalt fur Wiederaufbau (KfW), a major German investment bank, describes the efforts that this institution has made to stimulate the development of Entrepreneurship studies in German universities. These efforts got underway in 1998, when KfW financed the setting up of a professorial chair in new company formation at the European Business School in Oestrich‐Winkel. Other chairs in other German universities followed. The author outlines the challenges to such university programmes in Germany and lists a number of recommendations to make instruction in the subject successful. KfW is promoting the generalization of entrepreneurial culture, without which Germany will be excluded from major economic developments.
Safety evaluation of laninamivir octanoate hydrate through analysis of adverse events reported during early post-marketing phase vigilance

Abstract Background: Abnormal behavior and delirium are common in children with influenza. While abnormal behavior and delirium are considered to be associated with influenza encephalopathy, an increased risk of such neuropsychiatric symptoms in patients receiving neuraminidase inhibitor treatment is suspected. Laninamivir octanoate hydrate, recently approved in Japan, is a long-acting neuraminidase inhibitor. It is important to establish a safety profile for laninamivir early, based on post-marketing experiences. Methods: Spontaneous safety reports collected in the early post-marketing phase vigilance were analyzed. Adverse events of interest such as abnormal behavior/delirium, dizziness/vertigo, respiratory disorders, shock/syncope, and any other serious events were intensively reviewed by the Safety Evaluation Committee. Results: Abnormal behavior/delirium was a frequently reported event. Almost all the reported cases were considered to be due to influenza and not laninamivir. There were 32 cases of abnormal behavior/delirium that could lead to dangerous accidents, and these were observed more frequently in males and teenagers. Syncope probably related to the act of inhalation per se of laninamivir was reported during this survey. Conclusions: This safety review revealed that the safety profile of laninamivir for abnormal behavior/delirium and syncope was similar to that of other neuraminidase inhibitors. As stated in the labeling, teenage patients inhaling laninamivir should remain under constant parental supervision for at least 2 days and should be closely monitored for behavioral changes to prevent serious accidents associated with abnormal behavior/delirium. Furthermore, to avoid syncope because of inhalation, patients should be instructed to inhale in a relaxed sitting position.
A fast quasi-dense matching algorithm with an adaptive window

This paper presents a fast quasi-dense matching algorithm using an adaptive window. The algorithm starts from a set of sparse seed matches, then propagates to the neighboring pixels, finally the most points in the images are matched. During matching, we apply the convolution to the normalized cross correlation (NCC). The confidence coefficient is introduced and the search window is varied in inverse proportion to it. The algorithm has been tested with stereo images and the results demonstrate its accuracy and efficiency. The algorithm also can be applied to a wide range of image pairs including those with large disparity or without rectification even if part of the images are less textured. In particular, with big images and a large disparity range our algorithm turns out to be significantly faster.
Obesity in the media: social science weighs in

Obesity has become a mainstay of media in all its forms and sociologists and others have increasingly sought to understand what reporting on obesity can tell us about the construction of social problems, health, and health policy. In this commentary, I review recent social science writing on the representation of obesity in the media. I explore three dominant themes in this research, the framing of obesity in the media, media reporting of obesity research, and media characterizations of and reporting on obesity policy. I highlight the strengths of these studies and conclude with suggestions for further avenues of research.
Contextual Ranking of Keywords Using Click Data

The problem of automatically extracting the most interesting and relevant keyword phrases in a document has been studied extensively as it is crucial for a number of applications. These applications include contextual advertising, automatic text summarization, and user-centric entity detection systems. All these applications can potentially benefit from a successful solution as it enables computational efficiency (by decreasing the input size), noise reduction, or overall improved user satisfaction.In this paper, we study this problem and focus on improving the overall quality of user-centric entity detection systems. First, we review our concept extraction technique, which relies on search engine query logs. We then define a new feature space to represent the interestingness of concepts, and describe a new approach to estimate their relevancy for a given context. We utilize click through data obtained from a large scale user-centric entity detection system - Contextual Shortcuts - to train a model to rank the extracted concepts, and evaluate the resulting model extensively again based on their click through data. Our results show that the learned model outperforms the baseline model, which employs similar features but whose weights are tuned carefully based on empirical observations, and reduces the error rate from 30.22% to 18.66%.
Pose Estimation Using Active Shape Models and Learned Entropy Field Approximations

This report describes the implementation of a framework for exploring full-body, generative 2D pose estimation approach in single, broadcast quality frames. A dataset for training is manually constructed from image frames taken from NBA footage. Poses can be generated using an active shape model consisting of a simple linear combination requiring only a small number of parameters. To guide the search for an optimal pose, an energy function is proposed that compares image entropy with a learned entropy field estimator, computed using the current pose estimate. Current results are presented and future work or exploration is discussed.
A dynamic and adaptive quiescence detection algorithmAmitabh

A large number of quiescence detection algorithms with good theoretical upper-bounds have been proposed before. However the metric used to measure the performance of these algorithms is not suitable. We propose a new metric for measuring the performance of a quiescence detection algorithm. We also present an algorithm to detect quiescence in an asynchronous and dynamic model of parallel computation. The algorithm has been implemented for a machine independent parallel programming system, Charm. Quiescence detection is provided as a feature in Charm to conduct a variety of operations like collecting statistics about user computation, initiating new phases of computation, or just terminating the user computation.
TFP , News , and Expectations : The International Transmission of Business Cycles

We propose a novel identification scheme for a non-technology business cycle shock, that we label “non-technology expectations” (NTE). This is a shock orthogonal to identified surprise and news TFP shocks that maximizes the short-run forecast error variance of an expectational variable, alternatively a GDP forecast or a consumer confidence index. We then estimate the international transmission of three identified shocks – surprise TFP, news of future TFP, and NTE – from the US to Canada. The US non-technology shock produces a business cycle in the US, with output, hours, and consumption rising following a positive shock, and accounts for the bulk of US short-run business cycle fluctuations. The non-technology shock also has a significant impact on Canadian macro aggregates. In the short run, it is more important than either the surprise or the news TFP shocks in generating business cycle comovement between the US and Canada, accounting for over 40% of the forecast error variance of Canadian GDP and over one-third of Canadian hours, imports, and exports. The news shock is responsible for some comovement at 5-10 years, and surprise TFP innovations do not generate synchronization. We provide a simple theoretical framework to illustrate how US non-technology expectations shocks can transmit to Canada.
Anti-Diabetic Efficacy and Impact on Amino Acid Metabolism of GRA1, a Novel Small-Molecule Glucagon Receptor Antagonist

Hyperglucagonemia is implicated in the pathophysiology of hyperglycemia. Antagonism of the glucagon receptor (GCGR) thus represents a potential approach to diabetes treatment. Herein we report the characterization of GRA1, a novel small-molecule GCGR antagonist that blocks glucagon binding to the human GCGR (hGCGR) and antagonizes glucagon-induced intracellular accumulation of cAMP with nanomolar potency. GRA1 inhibited glycogenolysis dose-dependently in primary human hepatocytes and in perfused liver from hGCGR mice, a transgenic line of mouse that expresses the hGCGR instead of the murine GCGR. When administered orally to hGCGR mice and rhesus monkeys, GRA1 blocked hyperglycemic responses to exogenous glucagon. In several murine models of diabetes, acute and chronic dosing with GRA1 significantly reduced blood glucose concentrations and moderately increased plasma glucagon and glucagon-like peptide-1. Combination of GRA1 with a dipeptidyl peptidase-4 inhibitor had an additive antihyperglycemic effect in diabetic mice. Hepatic gene-expression profiling in monkeys treated with GRA1 revealed down-regulation of numerous genes involved in amino acid catabolism, an effect that was paralleled by increased amino acid levels in the circulation. In summary, GRA1 is a potent glucagon receptor antagonist with strong antihyperglycemic efficacy in preclinical models and prominent effects on hepatic gene-expression related to amino acid metabolism.
Curcumin sensitizes human lung cancer cells to apoptosis and metastasis synergistically combined with carboplatin

Although carboplatin is one of the standard chemotherapeutic agents for non-small cell lung cancer (NSCLC), it has limited therapeutic efficacy due to activation of a survival signaling pathway and the induction of multidrug resistance. Curcumin, a natural compound isolated from the plant Curcuma longa, is known to sensitize tumors to different chemotherapeutic agents. The aim of this study is to evaluate whether curcumin can chemosensitize lung cancer cells to carboplatin and to analyze the signaling pathway underlying this synergism. We investigated the synergistic effect of both agents on cell proliferation, apoptosis, invasion, migration, and expression of related signaling proteins using the human NSCLC cell line, A549. A549 cell was treated with different concentrations of curcumin and carboplatin alone and in combination. Combined treatment with curcumin and carboplatin inhibited tumor cell growth, migration, and invasion compared with either drug alone. Matrix metalloproteinase (MMP)-2 and MMP-9 were more efficiently downregulated by co-treatment than by each treatment alone. mRNA and protein expression of caspase-3 and caspase-9 and proapoptotic genes was increased in cells treated with a combination of curcumin and carboplatin, whereas expression of the antiapoptotic Bcl-2 gene was suppressed. Co-treatment of both agents substantially suppressed NF-κB activation and increased expression of p53. Phosphorylation of Akt, a protein upstream of NF-κB, was reduced, resulting in inhibition of the degradation of inhibitor of κB(IκBα), whereas the activity of extracellular signal-regulated kinase (ERK1/2) was enhanced. Our study demonstrated that the synergistic antitumor activity of curcumin combined with carboplatin is mediated by multiple mechanisms involving suppression of NF-κB via inhibition of the Akt/IKKα pathway and enhanced ERK1/2 activity. Based on this mechanism, curcumin has potential as a chemosensitizer for carboplatin in the treatment of patients with NSCLC.