Miracle-dz/UniFAR-FTUs huggingface dataset:
Nephrogenic adenoma identified on urine cytology using PAX‐2 immunostaining

Urine cytology is a sensitive and specific method in detecting urothelial carcinoma of the urinary bladder, particularly the high‐grade ones. However, the cytologic features of nonneoplastic lesions of the lower urinary tract, including nephrogenic adenoma, are nonspecific and may cause false positive diagnosis. Recent evidence has demonstrated that nephrogenic adenoma is a true “nephrogenic” lesion derived from the exfoliated and implanted renal tubular cells in the urinary tract. This has promoted the use of immunostaining of renal transcription factor PAX2 in tissue biopsies to differentiate nephrogenic adenoma from the common malignant tumors of the lower urinary tract. We report here that PAX2 immunostaining can also be used in urine cytology specimen to identify nephrogenic adenoma. Combination of PAX2 immunostaining and cytologic analysis may increase the accuracy in identifying this benign lesion in urine cytology specimen and therefore reduce unnecessary repeat cystoscopy and biopsy procedures. This may be a cost effective follow‐ up method for patients with an established diagnosis of nephrogenic adenoma. Diagn. Cytopathol. 2008;36:47–49. © 2007 Wiley‐Liss, Inc.
Systematic Review of Mindfulness Practice for Reducing Job Burnout.

OBJECTIVE A systematic search and critical appraisal of interdisciplinary literature was conducted to evaluate the evidence for practicing mindfulness to treat job burnout and to explore implications for occupational therapy practitioners. METHOD Eight articles met inclusion criteria. Each study was assessed for quality using the Physiotherapy Evidence Database scale. We used the U.S. Agency for Health Care Policy and Research guidelines to determine strength of evidence. RESULTS Of the studies reviewed, participants included health care professionals and teachers; no studies included occupational therapy practitioners. Six of the 8 studies demonstrated statistically significant decreases in job burnout after mindfulness training. Seven of the studies were of fair to good quality. CONCLUSION There is strong evidence for the use of mindfulness practice to reduce job burnout among health care professionals and teachers. Research is needed to fill the gap on whether mindfulness is effective for treating burnout in occupational therapy practitioners.
Precios internacionales, tipo de cambio y restricción externa: un análisis de equilibrio general computable

This paper analyzes the effect of a reduction in international commodity prices on the Argentinian economy. Using the CGE methodology two models were constructed. It was evaluated the role of the exchange rate and the external constraint using different assumptions. The first model has the standard features for developing countries, and the second uses the main structuralist assumptions. In both models, the exogenous shock had contractionary effects. In the standard model the adjustment of the real exchange rate reduces the negative impact on GDP, while in the structuralist model the absence of automatic adjustments deepens the fall in output. The latter specification allows to quantify the need for external financing and the evaluation of policies to manage the external constraint. Clasificacion JEL: C68, E27 Palabras clave: Equilibrio General Computable, Estructura Economica, Tipo de Cambio, Restriccion Externa. Este trabajo constituye la tesis de Maestŕia en Economia de la Universidad Nacional de La Plata (UNLP), realizada bajo la direccion de Martin Cicowiez. El autor agradece su valioso apoyo y dedicacion. Los errores u omisiones son de exclusiva responsabilidad del autor. Universidad Nacional de La Plata, mail: dnquaglia@hotmail.com.
Chemoprophylaxis in the prevention of tberculosis

Tuberculosis chemoprophylaxis is a therapeutic measure for the prevention of infection by Mycobacterium tuberculosis or to avoid development of the disease in individuals already infected with it. Isoniazid is the most commonly used therapy; however, the use of rifampicin and pyrazinamide has recently been introduced. The objectives of this study were to review the results of the principal studies evaluating the indications for chemoprophylaxis with isoniazid alone and in association with other drugs, its efficacy in the prevention of tuberculosis with respect to the different risk groups and the alternative regimens available. A systematic revision of the medical literature was carried out with particular emphasis on clinical trials and metaanalyses. Official records were also consulted. Those studies involving randomized clinical trials on the use of isoniazid, rifampicin or pyrazinamide in HIV-positive or negative patients were selected. Isoniazid continues to be effective for the prevention of tuberculosis in populations of both HIV-negative and HIV-positive individuals. The standard dose of 5-15 mg/kg/day has shown similar protection over treatment periods ranging from six to twelve months. The risk of developing hepatitis was less than 1%; however monitoring during treatment is recommended in patients over 35 years of age and in users of alcohol. Studies involving treatment regimens with other forms of medication were inconclusive and new studies would have to be performed to evaluate the efficacy of these regimens in populations at high risk of developing tuberculosis.
“Empowered patient” or “doctor knows best”? Political economy analysis and ownership

ABSTRACT Efforts to incorporate “political thinking” into policy-making and practice in OECD-DAC development agencies have increasingly focused on the use of “political economy analysis” (PEA) frameworks and tools. While recognising the fundamental value of promoting politically informed programming, this article nevertheless highlights how contemporary efforts to this end have largely ignored another central development agenda: the ownership paradigm. Emphasising the highly donor-centric nature of PEA design and methodology, we explore critiques and justifications of this state of affairs, ultimately arguing that donors would benefit from embracing a more flexible and context-specific understanding of ownership.
Androgen receptor binding to nuclear matrix in vitro and its inhibition by 8S androgen receptor promoting factor.

The partially purified 4.5S [3H]dihydrotestosterone receptor binds to nuclear matrix isolated from rat Dunning prostate tumor with properties similar to those reported for androgen receptor binding in intact nuclei [Colvard, D.S. , & Wilson, E.M. (1984) Biochemistry (preceding paper in this issue)] in that it requires Zn2+ and mercaptoethanol, is saturable, and is temperature dependent and of high affinity (Ka approximately 10(13) M-1). On a milligrams of DNA equivalent basis, the extent of matrix binding of androgen receptor (700 fmol of receptor bound/mg of matrix protein) is similar to that of intact nuclei, corresponding to approximately 1400 sites/nucleus. Association rate constants (ka) for 4.5S androgen receptor binding to matrix at 0, 15, and 25 degrees C are 2.7 X 10(5), 1.2 X 10(6), and 2.4 X 10(6) M-1 min-1, respectively, indicating an energy of activation of 15 kcal/mol. Up to 50% of matrix-bound receptor is extractable in buffer containing 3 mM ethylenediaminetetraacetic acid plus either 0.4 M KCl or 5 mM pyridoxal 5'-phosphate. A protein fraction designated 8S androgen receptor promoting factor that promotes conversion of the 4.5S androgen receptor to 8 S [Colvard, D. S. , & Wilson, E. M. (1981) Endocrinology (Baltimore) 109, 496-504] has been further purified and found to inhibit the binding of the 4.5S androgen receptor to isolated nuclei and nuclear matrix in a concentration-dependent manner. The results support the hypothesis that the 8S steroid receptor is a complex of the activated 4.5S androgen receptor with a non-steroid binding protein that renders the receptor incapable of binding in nuclei.
Subcloning, expression, purification, and characterization of Haemophilus influenzae glycerol kinase.

Glycerol kinase (EC 2.7.1.30) is a bacterial sugar kinase and a member of the sugar kinase/actin/hsc-70 superfamily of enzymes. The enzyme from Escherichia coli is an allosteric regulatory enzyme whose activity is inhibited by fructose 1,6-bisphosphate (FBP) and the glucose-specific phosphocarrier of the phosphoenolpyruvate:glycose phosphotransferase system, IIA(Glc) (previously termed III(Glc)). Comparison of its primary structure with that of the highly similar Haemophilus influenzae glycerol kinase reveals that the amino acid sequence for the binding site for FBP is conserved while the amino acid sequence for the binding site for IIA(Glc) contains differences that are predicted to prevent its inhibition. To test this hypothesis, the H. influenzae glpK gene was assembled from DNA library fragments and subcloned into pUC18. The enzyme is expressed at high levels in E. coli. It was purified to greater than 90% homogeneity by taking advantage of its solubility behavior in a procedure that requires no column chromatography. The initial-velocity kinetic parameters of the purified enzyme are similar to those of the E. coli glycerol kinase. The H. influenzae glycerol kinase is inhibited by FBP but not by IIA(Glc), in agreement with the prediction based on sequence comparison. Sedimentation velocity experiments reveal that inhibition of HiGK by FBP is associated with oligomerization, behavior which is similar to EcGK. The possibility of utilizing mutagenesis studies to exploit the high degree of similarity of these two enzymes to elucidate the mechanism of allosteric regulation by IIA(Glc) is discussed.
Physical activity and body mass: changes in younger versus older postmenopausal women.

PURPOSE The study's purpose was to investigate the relationship of sedentary (≤ 100 MET · min · wk(-1)), low (>100-500 MET · min · wk(-1)), moderate (>500-1200 MET · min · wk(-1)), and high (>1200 MET · min · wk(-1)) habitual physical activity with body weight, body mass index, and measures of fat distribution (waist-to-hip ratio) in postmenopausal women by age decades. METHODS A prospective cohort study of 58,610 postmenopausal women age 50-79 yr weighed annually during 8 yr at one of 40 US clinical centers was analyzed to determine the relationship of high versus low habitual physical activity with changes in body weight and fat distribution by age group. RESULTS Among women age 50-59 yr, there was significant weight loss in those expending >500-1200 MET · min · wk(-1) (coefficient = -0.30, 95% confidence interval = -0.53 to -0.07) compared with the group expending ≤ 100 MET · min · wk(-1). Among women age 70-79 yr, higher physical activity was associated with less weight loss (coefficient = 0.34, 95% confidence interval = 0.04-0.63). Age at baseline significantly modified the association between physical activity and total weight change, whereas baseline body mass index did not. CONCLUSIONS High habitual physical activity is associated with less weight gain in younger postmenopausal women and less weight loss in older postmenopausal women. These findings suggest that promoting physical activity among postmenopausal women may be important for managing body weight changes that accompany aging.
Editors Can Lead Researchers to Confidence Intervals, but Can't Make Them Think

Since the mid-1980s, confidence intervals (CIs) have been standard in medical journals. We sought lessons for psychology from medicine's experience with statistical reform by investigating two attempts by Kenneth Rothman to change statistical practices. We examined 594 American Journal of Public Health (AJPH) articles published between 1982 and 2000 and 110 Epidemiology articles published in 1990 and 2000. Rothman's editorial instruction to report CIs and not p values was largely effective: In AJPH, sole reliance on p values dropped from 63% to 5%, and CI reporting rose from 10% to 54%; Epidemiology showed even stronger compliance. However, compliance was superficial: Very few authors referred to CIs when discussing results. The results of our survey support what other research has indicated: Editorial policy alone is not a sufficient mechanism for statistical reform. Achieving substantial, desirable change will require further guidance regarding use and interpretation of CIs and appropriate effect size measures. Necessary steps will include studying researchers' understanding of CIs, improving education, and developing empirically justified recommendations for improved statistical practice.
Chemical signals in the marine environment: dispersal, detection, and temporal signal analysis.

Chemical signals connect most of life's processes, including interorganismal relationships. Detection of chemical signals involves not only recognition of a spectrum of unique compounds or mixtures of compounds but also their spatial and temporal distribution. Both spectral and temporal signal processing determine what is a signal and what is background noise. Each animal extracts its unique information from the chemical world and uniquely contributes to it. Lobsters have provided important information on temporal signal processing. Marine chemical signals can be measured with high spatio-temporal resolution giving us a novel view of the lobster's environment. Lobster chemoreceptor cells have flicker fusion frequencies of 4 Hz and can integrate stimuli over 200 ms, closely corresponding to odor sampling behavior with 4-Hz "sniffs. " Using this information, spatial odor gradients can be determined from temporal analysis of odor patches typical of turbulent dispersal. Lobsters appear to use this information to locate odor sources. Lobster social behavior depends greatly on chemical signals. Urine carries important information for courtship, dominance, and individual recognition. A novel gland in the nephropore is strategically located to release its products into the urine. Urine, in turn, is injected into the gill current, which jets water 1-2 m ahead of the animal. Lobsters control three different currents that carry chemical signals to and from them. The study of odor dynamics has only just begun. It will be exciting to see how signal dispersal, receptor temporal tuning, neural processing, and animal behavior interact to enhance signals for communication and detection and to reduce signals for chemical camouflage.
Glucose transporter-1 expression in squamous cell carcinoma of the tongue.

PURPOSE Tumor cells are known to express hypoxia-related proteins such as glucose transporter-1 (Glut-1). These hypoxia-induced changes may allow tumor cells to survive under sustained hypoxic microenvironments, and the surviving tumor cell under hypoxia may develop a more aggressive phenotype and so result in a poor prognosis. MATERIALS AND METHODS The Glut-1 expression was analyzed by immunohistochemistry, and its association with the prognosis was assessed in 60 patients with squamous cell carcinoma of the tongue. RESULTS The Glut-1 expression was diffuse with a membranous pattern, and the median percentage of Glut-1 positive tumor cells was 60% (range: 0.0 approximately 90.0%). A high Glut-1 expression (the percentage of positive tumor cells >or= the median value, 60%) was associated with the location of primary lesion, lymph node metastasis status and disease stage (p<0.05). The expression of Glut-1 was correlated with the Ki-67 expression (r=0.406, p=0.001). Microvessel density, as represented by CD31 staining, was also correlated with the Glut-1 expression although its significance is weak (r=0.267, p=0.039). On the univariate analysis, the group with a high Glut-1 expression showed poorer overall survival than the group with a low Glut-1 expression (p<0.05). However, the Glut-1 expression failed to show any independent prognostic significance on the multivariate analysis. CONCLUSION The expression of Glut-1 may be useful for predicting the prognosis and determining the treatment strategy for the management of squamous cell carcinoma of the tongue.
Sustaining Smallholder Farmers’ Livelihoods through Rainfall-Deficit-Index-Based Crop Insurance in Drought-Prone Areas: Lessons from Ethiopia

The main objective of this article is to assess the contributions in sustaining the livelihoods of smallholder farmers of rainfall-deficit-index-based crop insurance pilot project based on haricot beans implemented in Ethiopia in 2009. Based on cross-sectional data, assessment results revealed that crop insurance has a potential in sustaining the livelihoods of smallholder farmers, but that there was a problem of information flow, belated payout and inadequate consideration of farmers’ preferences. Scaling-up crop insurance scheme in the future increasingly depends upon building farmers’ knowledge on how the scheme works, through proper agricultural extension services and farmers’ active participation. Signifying crop insurance as an appropriate risk management strategy, the article underlines the importance of public extension services besides appreciating farmers’ motivations to take over the management and leadership of their own affairs when existing structures are not responsive in the context of practicing crop insurance.
Parental influence on clinical management during neonatal intensive care: a survey of US neonatologists

Abstract Objective: Family-centered care (FCC), which includes involving parents in conversations about medical management, is increasingly employed in the neonatal intensive care unit (NICU). Our aim was to determine which care decisions are discussed by neonatologists with families most frequently and the percentage of clinicians influenced by such conversations. Methods: Anonymous web-based survey provided to 2137 neonatologists assessing information sharing and parental involvement. Results: Thousand and two neonatologists responded in which 893 fully completed the surveys. 88% practice FCC. Topics most frequently discussed with parents were blood transfusion, steroids for lung disease and patent ductus arteriosus (PDA) surgery, each being reported and discussed by more than 90% of respondents. Many therapies, including aminoglycoisdes, total parenteral nutrition, and phototherapy, were discussed with parents by far fewer clinicians. Additionally, parents had most influence on clinicians in two categories, blood transfusion and steroids, with more than 70% reporting that their practice was influenced by parental opinion if communicated. For some topics, such as PDA surgery and central line placement, conversations impacted few clinicians. Conclusions: FCC appears to have an impact on NICU clinical decision-making processes, some more than others. Further investigation in this area may provide information on how to best communicate with families and run effective, efficient FCC rounds.
PUTTING TRANSPORTATION AND ECONOMIC DEVELOPMENT INTO PERSPECTIVE

Economic development occurs when the income and product generated within an area increase. Government policies can promote economic development by helping an area increase the returns from using resources there. They do this by providing services that produce benefits in excess of their costs. Transportation services generate benefits by serving as an economic tool used in transporting goods and people. The benefits of transportation investments are strictly related to reductions in transportation costs. These investments foster economic development by increasing net local income through cost reductions that exceed the cost of such investments. A series of important issues should be taken into account when examining the extent to which a transportation investment contributes to economic development. The issues include the scale of the impact area to be considered because some activity will move from one location to another, because of uncertainties in future economic circumstances, and for social objectives. For example, policy trade-offs must be made between maximizing overall economic development within a state and assisting a less-promising but needy area. Six paradigms illustrate the types of trade-offs that decision makers face when using transportation investments to foster local economic development. Finally, a series of decision screens are presented to provide a practical basis for applying the principles discussed.
Crowdsourcing an OCR Gold Standard for a German and French Heritage Corpus

Crowdsourcing approaches for post-correction of OCR output (Optical Character Recognition) have been successfully applied to several historic text collections. We report on our crowd-correction platform Kokos, which we built to improve the OCR quality of the digitized yearbooks of the Swiss Alpine Club (SAC) from the 19th century. This multilingual heritage corpus consists of Alpine texts mainly written in German and French, all typeset in Antiqua font. Finding and engaging volunteers for correcting large amounts of pages into high quality text requires a carefully designed user interface, an easy-to-use workflow, and continuous efforts for keeping the participants motivated. More than 180,000 characters on about 21,000 pages were corrected by volunteers in about 7 month, achieving an OCR gold standard with a systematically evaluated accuracy of 99.7% on the word level. The crowdsourced OCR gold standard and the corresponding original OCR recognition results from Abby FineReader 7 for each page are available as a resource. Additionally, the scanned images (300dpi) of all pages are included in order to facilitate tests with other OCR software.
Cooperation in the Finitely Repeated Prisoner's Dilemma

More than half a century after the first experiment on the finitely repeated prisoner's dilemma, evidence on whether cooperation decreases with experience, as suggested by backward induction, remains inconclusive. This paper provides a meta-analysis of prior experimental research and reports the results of a new experiment to elucidate how cooperation varies with the environment in this canonical game. We describe forces that affect initial play (formation of cooperation) and unraveling (breakdown of cooperation). First, contrary to the backward induction prediction, the parameters of the repeated game have a signifcant effect on initial cooperation. We identify how these parameters impact the value of cooperation - as captured by the size of the basin of attraction of Always Defect- to account for an important part of this effect. Second, despite these initial differences, the evolution of behavior is consistent with the unraveling logic of backward induction for all parameter combinations. Importantly, despite the seemingly contradictory results across studies, the paper establishes a systematic pattern of behavior: Subjects converge to using threshold strategies that conditionally cooperate until a threshold round; and conditional on establishing cooperation, the first defection round moves earlier with experience. Simulation results generated from a learning model estimated at the subject level provide insights on the long-term dynamics and the forces slowing down the unravelling of cooperation.