Miracle-dz/UniFAR-FTUs huggingface dataset:
Neural correlates of aggression outcome expectation and their association with aggression: A voxel-based morphometry study

Background. The aggression outcome expectation is believed to be an important cognitively influencing factor of aggression. Discovering the neural mechanism of aggression outcome expectation is conductive to develop aggression research. However, the neural correlates underlying aggression outcome expectation and its deleterious effect remain elusive. Methods. In this study, we utilized voxel-based morphometry (VBM) to unravel the neural architecture of aggression outcome expectation measured by the Social Emotional Information Processing Assessment for Adults and and its relationship with aggression measured by the Buss Perry Aggression Questionnaire in a sample of 185 university students (114 female; mean age = 19.94 plus/minus 1.62 years; age range: 17-32 years). Results. The results showed a significantly positive correlation between aggression outcome expectation and the regional gray matter volume (GMV) in the right middle temporal gyrus (MTG) (x = 55.5, y = -58.5, z = 1.5; t =3.35; cluster sizes =352, p < 0.05, GRF corrected). Moreover, aggression outcome expectation acted as a mediator underlying the association between the right MTG volume and aggression. Conclusions. These results found the neural correlates of aggression outcome expectation and its effect on aggression for the first time, which may contribute to our understanding of the cognitive neural mechanism of aggression and tentatively provide an effective method to identify potential neurobiological markers for aggression.
Contribution à l'étude des interactions végétation-atmosphère en milieu tropical humide : importance du rôle du système forestier dans le recyclage des eaux de pluie

La zone forestiere de la region tropicale humide de l'Afrique de l'Ouest participe activement au maintien d'un equilibre climatique dont le moteur est la Circulation Atmospherique Generale. Toutefois, en raison de la pression demographique, l'evolution actuelle de cette region forestiere necessite de promouvoir un developpement agricole conforme a la vocation hydro climatique. Le travail presente contribue a mieux evaluer l'Impact de la modification physionomique du couvert forestier dans cette zone. Il constitue une participation a ce vaste programme. Dans le present travail, te premier objectif, a caractere agronomique, est d'etudier le comportement d'un couvert forestier amenage d’Hevea brasiliensis (produit recolte: caoutchouc) introduit recemment dans la zone forestiere en Cote d'Ivoire dans le cadre d'une politique de mise en valeur regionale. L'etude passe par l'analyse des echanges energetiques au niveau de l'interface foret-atmosphere a l'aide de la methode du bilan d'energie (rapport de Bowen) associee au bilan hydrique. La quantification des differents processus, en fonction des conditions edapho-climatiques, a permis de modeliser les mecanismes du fonctionnement du couvert forestier d’Hevea et de determiner les facteurs climatiques limitant son rendement: distribution des pluies et rayonnement solaire. Le second objectif, a caractere climatique, est de determiner le bilan hydrologique regional a l'aide d'un modele realiste permettant l'evaluation des transferts, en particulier celui de la vapeur d'eau. Les resultats de la modelisation realisee a l'aide des donnees obtenues sur un bassin versant de la region sud-ouest de la zone forestiere montrent que: la foret, de par sa structure verticale aerienne et souterraine, injecte l'equivalent de 55 a 70% des precipitations annuelles dans l'atmosphere, ce qui permet aux parametres physiques de la masse d'air (humidite et temperature) en provenance de l'ocean de ne pas trop changer; toute modification de la surface forestiere perturbe non seulement les echanges de chaleur e-t de vapeur d'eau au cours de l'annee mais affecte egalement la repartition des eaux de pluies, en particulier le ruissellement et l'ecoulement en profondeur. L'introduction a grande echelle, de couverts annuels dans la zone forestiere modifierait les equilibres energetique et hydrique dont l'impact se repercuterait sur les regions situees en aval de l'avancee de l'Equateur Meteorologique, repondant partiellement a la question de la desertisation des regions saheliennes.
chFr promotes the migration of human gastric cancer cells by inducing epithelial-to-mesenchymal transition in a hDac1-dependent manner

Background: Previous studies have illustrated that checkpoint with forkhead-associated and ring finger domains (CHFR) was frequently silenced in several cancer types due to promoter hypermethylation and functions as a tumor suppressor gene. However, the data from the public dataset reveal that CHFR is highly expressed in human gastric cancer specimens, and the biological function of CHFR in gastric cancer is still not well understood. The clinical association between CHFR expression and the overall survival of gastric cancer patients as well as cancer metastasis was analyzed according to public datasets. The CHFR expression in clinical specimens and human gastric cancer cell lines was detected by immunohistochemistry and Western blotting, respectively. Gain (overexpres-sion) and loss (silencing) of function experiments were used to elucidate the role of CHFR in gastric cancer. The migration ability of gastric cancer cells was determined by wound healing and transwell assays. Cell cycle distribution was analyzed using fluorescence-activated cell sorting experiment. The expression of the proteins in cancer cells was measured using Western blot analysis. Results: According to the analysis from Kaplan–Meier plotter dataset, CHFR expression was negatively associated with overall survival of gastric cancer patients. Our data revealed that exogenous expression of CHFR not only arrested cell cycle but also led to dramatically enhanced cell migration, while silencing of CHFR significantly inhibited cell migration in gastric cancer cells. This result is consistent with the data from the Human Cancer Metastasis Dataset, in which CHFR level is found to significantly increase in metastatic gastric cancer. The overexpression of CHFR promoted epithelial–mesenchymal transition (EMT) in both SGC-7901 and AGS cells, while HDAC1 was inhibited. Interestingly, suberoylanilide hydroxamic acid, a HDAC1 antagonist, could effectively increase cell migration in both cell lines via enhancement of EMT. Conclusion: Our data indicated that CHFR exerted positive effects on cell migration of human gastric cancer by promoting EMT via downregulating HDAC1.
Prevalence and Determinants of Depression, Anxiety, and Stress Among Secondary School Students

Background: Adolescence represents a critical period characterized by extensive changes across various domains. While some of the changes and behaviors that emerge during this period can have detrimental effects on adolescents' present and future health, mental health disorders continue to constitute a leading cause of morbidity among young individuals. Objective: Assess the prevalence and determinants of depression, anxiety, and stress among secondary school students in Saudi Arabia. Methods: This analytical cross-sectional study utilized an online questionnaire to collect responses from secondary school students in Saudi Arabia. The Arabic version of the Depression, Anxiety, and Stress Scale - 21 Items (DASS-21) was used to measure depression, anxiety, and stress levels. Data were analyzed using IBM Statistical Package for the Social Sciences software (SPSS, version 29.0, IBM Corp., Armonk, NY, USA). The study included 702 participants. Results: The prevalence of anxiety was 35.2%, followed by depression (30.8%) and stress (14.7%). Females had significantly higher anxiety and stress scores than males (P=0.004, and P=0.011, respectively). Students who were bullied in the last 30 days had significantly higher depression, anxiety, and stress scores than those who were not bullied (P<0.001 for all). Participants who experienced physical assault in the last 12 months had significantly higher depression, anxiety, and stress scores than those who did not (P<0.001 for all). Participants who had had fights in the last 12 months had significantly higher depression (P=0.004) and anxiety (P<0.001) scores than those who did not. Participants who felt unsafe on the way to school had significantly higher depression, anxiety, and stress scores than those who did not (P<0.001 for all). Conclusion: The study revealed prevalence rates of depression (30.8%), anxiety (35.2%), and stress (14.7%) among secondary school students in Saudi Arabia. The study highlights the importance of addressing social stressors such as bullying and physical assault and promoting a safe and supportive school environment to prevent mental health disorders in this population.
Metagranites from SW Bulgaria as a part of the Neoproterozoic to early Paleozoic system in Europe: new insight from zircon typology, U-Pb isotope data and Hf-tracing

Two varieties of metagranitoids are distinguished: equigranular and porphyritic. They are deformed, metamorphosed (amphibolite facies overprinted – 650 ◦ C and 7–8 kbar) and uneven migmatized with augen, augenlayered or layered structure. Less deformed parts reveal magmatic peculiarities: micro-granular enclaves, zonal-arranged plagioclase inclusions in potassium feldspar porphyroclasts and foliated aplitic and pegmatitic dikes. Petrochemical and geochemical features point to predominantly crustal origin (ASI 1.02–1.48). Discriminant diagrams are controversial and argue for VAG and post-collisional geodynamic environment.
Prognostic significance of EIF4G1 in patients with pancreatic ductal adenocarcinoma

Background: Advances in genomics have greatly improved the survival rate in cancer patients. However, due to genetic heterogeneity, pancreatic ductal adenocarcinoma (PDAC) is still difficult to diagnose early, and its survival rate is extremely low. Therefore, we identified biomarkers that predict the prognosis of PDAC patients using independent cohort data. Materials and methods: To develop a novel prognostic biomarker, we used the gene expression and clinical data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). Kaplan–Meier survival curve using median values of genes as cutoff showed that EIF4G1 was the only statistically significant gene in the 3 cohorts. We analyzed the prognostic significance of EIF4G1 using the time-dependent area under the curve (AUC) of Uno’s C-index, the AUC value of the receiver operating characteristics (ROC) at 3 years, and multivariate Cox analysis. We also compared EIF4G1 levels between tumors and matched non-tumor tissues. Results: EIF4G1 is the only prognostic gene in patients with PDAC, which was selected by Kaplan–Meier survival analysis. The survival curve showed that high expression of EIF4G1 was associated with poor prognosis of PDAC with a good discriminative ability in 3 independent cohorts. The risk stratifying ability of EIF4G1 was demonstrated by analyzing C-indices and AUC values. Multivariate Cox regression confirmed its prognostic significance. EIF4G1 expression was significantly higher in PDAC tissues than in the matched normal tissues. Conclusion: EIF4G1 could be used as a novel prognostic marker for PDAC and to determine suitable treatment options.
In vivo super-resolution photoacoustic computed tomography by localization of single dyed droplets

The spatial resolution of photoacoustic (PA) computed tomography (PACT) is limited by acoustic diffraction. Here, we report in vivo superresolution PACT, which breaks the acoustic diffraction limit by localizing the centers of single dyed droplets. The dyed droplets generate much stronger PA signals than blood and can flow smoothly in blood vessels; thus, they are excellent tracers for localization-based superresolution imaging. The flowing droplets were first localized, and then their center positions were used to construct a superresolution image that exhibits sharper features and more finely resolved vascular details. A 6-fold improvement in spatial resolution has been realized in vivo.
GSCT uses X-rays and expresses the absorption of the energy spectrum based on tissue composition and lesions, providing quantitative analysis. Transforming CT from single parameter imaging to multi-parameter imaging enables the quantitative measurement of material properties and composition analysis

A variety of imaging methods can be used in the diagnosis of atherosclerotic plaques. In the present study, we investigated the morphology and composition of atherosclerotic plaque associated with ischemic cerebral infarction by comparing gemstone spectral computed tomography (GSCT) and traditional multi-slice CT (MSCT). In total, 200 patients were enrolled and divided into the experimental group (n=100), which underwent GSCT, and the control group (n=100), which underwent MSCT. All the cases were followed up to observe disease outcomes in patients with different atherosclerotic plaque types, and adverse events in carotid artery stenosis or cerebral infarction were recorded. Compared with traditional MSCT, sensitivity (93.2%), specificity (84.5%), and accuracy (91.0%) of GSCT were significantly higher. We found a correlation between vulnerable plaque of carotid atherosclerotic plaque and the occurrence of cerebral infarction. These results suggest the advantages of GSCT in analyzing atherosclerotic plaque and predicting the risk of ischemic cerebral infarction.
Extracellular Biosynthesis of Silver Nanoparticles by Endophytic Fungus Aspergillus terreus and its Anti-dermatophytic Activity

The emerging of nanoparticles into the living system especially for medical purposes has opened up a new challenge of synthesizing them in a benign fashion. In the present study, 5 endophytic fungi were isolated from the mangrove leaves of Rhizophora annamalayanna and among that A. terreus was produced the AgNPs extracellularly and the presence of AgNPs was confirmed by XRD, SEM with EDX, TEM and FTIR. Crystalline nature of AgNPs observed in XRD. SEM with EDX and TEM confirmed the presence of AgNPs, reveals that are predominantly spherical in the size of 100nm. FT-IR analysis confirmed the presence of proteins over the AgNPs which acts as a capping agent involved in the reduction of Ag to Ag
The Impact of Psychological Empowerment on Lecturers’ Innovative Behaviour in Malaysian Private Higher Education Institutions

Psychological empowerment comprising four cognitive dimensions i.e meaning, competence, autonomy and impact in the context of private higher education institutions was validated. The behavioral outcome of psychological empowerment was operationalized as innovative behavior. This study examined on a sample of 312 lecturers from 25 private higher education institutions in three states (Penang, Kedah and Kelantan) in Malaysia. The study verified the validity of the psychological empowerment scale of comprising four dimensions whereas innovative behaviour scale was unidimensional. Survey data was analyzed using correlation and regression analyses to assess the relationship between psychological empowerment and innovative behaviour as well as the impact of psychological empowerment on the behavioral outcome. The results indicate that psychological empowerment has significant relationship with innovative behaviour. Psychological empowerment is also found to be a significant predictor of innovative behavior (adjusted R2 = .109). Key words: Academia; Psychological empowerment; innovative behaviour; Private Higher Education; Malaysia Resume: L’habilitation psychologique qui comprend quatre dimensions cognitives, c'est-a-dire le sens, la competence, l'autonomie et l'impact dans le contexte des etablissements de l'enseignement superieur prives a ete validee. Le resultat comportemental de l'habilitation psychologique a ete operationnalisee en tant qu’un comportement innovateur. Cette etude a examine un echantillon de 312 enseignants de 25 etablissements de l'enseignement superieur prives dans trois provinces (Penang, Kedah et Kelantan) en Malaisie. L'etude a verifie la validite de l'echelle de l’habilitation psychologique comportant quatre dimensions alors que l'echelle des comportements innovateurs est unidimensionnelle. Les donnindiquent qu’il y a une relation significative entre l'habilitation psychologique et les comportements innovateurs. L’habilitation est egalement un facteur predictif important de comportements innovateurs. Mots-Cles: academie; habilitation psychologique; comportements innovateurs; enseignement superieur prive ; Malaisie
Enhancing the removal of a diverse range of hazardous chemicals from wastewaters

Due to increasingly stringent legislation covering the discharge of hazardous chemicals into the environment, existing wastewater treatment processes need to be upgraded for their removal. This thesis explores the removal of a diverse range of hazardous chemicals during secondary wastewater treatment with the overall aim of enhancing their removal simultaneously by activated sludge. Previous research in this field has made the broad comparison of full-scale activated sludge plants (ASPs) which receive varying influent sewage compositions and flow. Consequently, assessing the direct impact of process operation to hazardous chemical removal has been difficult. In this study, the independent impact of the process variables solids retention time (SRT) and hydraulic retention time (HRT) were examined using a pilot-scale ASP. To measure ASP resilience for the removal of a wide range of hazardous chemicals of varied chemistry and preferred removal pathways steroid estrogens, nonylphenolic surfactants and metals were monitored. In pilot plant trials where SRT was varied and HRT fixed, the highest SRT studied (27 days) achieved the greatest removal of all hazardous chemicals collectively. Interestingly, significantly greater estrogen biodegradation per viable bacterial cell was observed as SRT increased. To demonstrate, estrogen biodegradations were 499, 1,361 and 1,750 ng 1 x 10 12 viable cells -1 d -1 for 3, 10 and 27 day SRTs respectively, suggesting a more responsive bacteria or an improved efficiency of the same bacteria at higher SRTs. Successful implementation of higher SRT at full-scale ASPs requires more control over process operation. The use of in-situ suspended solids probes and real-time flow measurements could achieve this. In trials investigating the impact of altering HRT (whilst at a fixed SRT of 27 days), lengthening HRT was beneficial to the biodegradation of the organic hazardous chemicals. To demonstrate, estrogen biodegradations were 90 ±2 %, 93 ±1 % and 96 ±2 % for 8, 16 and 24 hour HRTs, respectively. Most significantly, 17α-ethinylestradiol exhibited removals of 65 ±19 % at the 24 hour HRT condition, the highest observed in these studies. Furthermore, nonylphenol removals were greater (63-70 %) at longer HRTs. However, longer HRT resulted in increased solubilisation of particulate metals. This is of concern as only dissolved concentrations are considered for environmental compliance. Consequently, any operational change to lengthen HRT for organic hazardous chemicals removal requires suitable provisions to enhance the removal of particle bound metals during primary treatment. It has been demonstrated that ASP operation can be modified to specifically target the removal of a diverse range of hazardous chemicals. TABLE OF CONTENTS ACKNOWLEDGEMENTS . i LIST OF FIGURES . ii LIST OF TABLES . iv ABBREVIATIONS . vi NOTATIONS . viii
VAMPr : VAriant Mapping and Prediction of antibiotic resistance via 1 explainable features and machine learning 2

4 Department of Statistical Science, Southern Methodist University, Dallas, TX 75275, USA 11 5 Harold C. Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, 12 75390, USA 13 6 Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, 14 USA 15 7 Department of Infectious Diseases and Genomic Medicine, University of Texas MD Anderson Cancer 16 Center, Houston, Texas, USA 17 8 Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA 18 9 Center for Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, Texas, 19 75390, USA 20 21 22
CLEP_A_237060 173..182

Sara Marie Nilsen* Johan Håkon Bjørngaard * Fredrik Carlsen Kjartan Sarheim Anthun Lars Gunnar Johnsen Lars Johan Vatten Andreas Asheim 1,8 1Center for Health Care Improvement, Trondheim University Hospital, Trondheim, Norway; 2Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway; 3Faculty of Nursing and Health Sciences, Nord University, Levanger, Norway; 4Department of Economics, Norwegian University of Science and Technology, Trondheim, Norway; 5Department of Health Research, SINTEF Digital, Trondheim, Norway; 6Department of Orthopaedic Surgery, Trondheim University Hospital, Trondheim, Norway; 7Department of Neuromedicine, Norwegian University of Science and Technology, Trondheim, Norway; 8Department of Mathematical Sciences, Norwegian University of Science and Technology, Trondheim, Norway
Ventilation Techniques and Risk for Transmission of Coronavirus Disease, Including COVID-19

Background: Mechanical ventilation is used to treat respiratory failure in coronavirus disease 2019 (COVID-19). Purpose: To review multiple streams of evidence regarding the benefits and harms of ventilation techniques for coronavirus infections, including that causing COVID-19. (PROSPERO registration: CRD42020178187) Data Sources: 21 standard, World Health Organization–specific and COVID-19–specific databases, without language restrictions, until 1 May 2020. Study Selection: Studies of any design and language comparing different oxygenation approaches in patients with coronavirus infections, including severe acute respiratory syndrome (SARS) or Middle East respiratory syndrome (MERS), or with hypoxemic respiratory failure. Animal, mechanistic, laboratory, and preclinical evidence was gathered regarding aerosol dispersion of coronavirus. Studies evaluating risk for virus transmission to health care workers from aerosol-generating procedures (AGPs) were included. Data Extraction: Independent and duplicate screening, data abstraction, and risk of bias assessment (GRADE for certainty of evidence and AMSTAR 2 for included systematic reviews). Data Synthesis: 123 studies were eligible (45 on COVID-19, 70 on SARS, 8 on MERS), but only 5 studies (1 on COVID-19, 3 on SARS, 1 on MERS) adjusted for important confounders. A study in hospitalized patients with COVID-19 reported slightly higher mortality with noninvasive ventilation (NIV) than with invasive mechanical ventilation (IMV), but 2 opposing studies, 1 in patients with MERS and 1 in patients with SARS, suggest a reduction in mortality with NIV (very low-certainty evidence). Two studies in patients with SARS report a reduction in mortality with NIV compared with no mechanical ventilation (low-certainty evidence). Two systematic reviews suggest a large reduction in mortality with NIV compared with conventional oxygen therapy. Other included studies suggest increased odds of transmission from AGPs. Limitation: Direct studies in COVID-19 are limited and poorly reported. Conclusion: Indirect and low-certainty evidence suggests that use of NIV, similar to IMV, probably reduces mortality but may increase the risk for transmission of COVID-19 to health care workers. Primary Funding Source: World Health Organization.