Miracle-dz/UniFAR-FTUs huggingface dataset:
The Dreyfus affair : the story of the most infamous miscarriage of justice in French history

Intelligent, ambitious and a rising star in the French artillery, Captain Alfred Dreyfus appeared to have everything: family, money, and the prospect of a post on the General Staff. But his rapid rise had also made him enemies - many of them aristocratic officers in the army's High Command who resented him because he was middle-class, meritocratic and a Jew. In October 1894, the torn fragments of an unsigned memo containing military secrets were retrieved by a cleaning lady from the waste paper basket of Colonel Maximilien von Schwartzkoppen of the German embassy in Paris. When French intelligence discovered they harboured a spy in their midst, Captain Dreyfus, on slender evidence, was charged with selling military secrets to the Germans, found guilty of treason by unanimous verdict and sentenced to life imprisonment on the notorious Devil's Island. The fight to free the wrongfully convicted Dreyfus - over twelve long years, through many trials - is a story rife with heroes and villains, courage and cowardice, dissimulation and deceit. One of the most infamous miscarriages of justice in history, the Dreyfus affair divided France, stunned the world and unleashed violent hatreds and anti-Semitic passions which offered a foretaste of what was to play out in the long, bloody twentieth century to come. Today, amid charged debates over national and religious identity across the globe, its lessons throw into sharp relief the conflicts of the present. In the hands of historian, biographer and prize-winning novelist Piers Paul Read, this masterful epic of the struggle between a minority seeking justice and a military establishment determined to save face comes dramatically alive for a new generation.
Smart Contact Lenses—A Step towards Non-Invasive Continuous Eye Health Monitoring

According to the age-old adage, while eyes are often considered the gateway to the soul, they might also provide insights into a more pragmatic aspect of our health: blood sugar levels. This potential breakthrough could be realized through the development of smart contact lenses (SCLs). Although contact lenses were first developed for eyesight correction, new uses have recently become available. In the near future, it might be possible to monitor a variety of ocular and systemic disorders using contact lens sensors. Within the realm of glaucoma, SCLs present a novel prospect, offering a potentially superior avenue compared to traditional management techniques. These lenses introduce the possibility of non-invasive and continuous monitoring of intraocular pressure (IOP) while also enabling the personalized administration of medication as and when needed. This convergence holds great promise for advancing glaucoma care. In this review, recent developments in SCLs, including their potential applications, such as IOP and glucose monitoring, are briefly discussed.
THE RELATIONSHIP BETWEEN MOTOR ACTIVITY AND EXECUTIVE FUNCTIONS IN THE TEACHING-LEARNING PROCESS: CASE OF 6 - 7 AGED TUNISIAN PUPILS

Considering that the cognitive and motor dimensions of human beings grow together and that primary school age is one of the most important stages of children’s cognitive and motor development, the aim of this study was to investigate the relationship between executive functions and motor activity in the teaching-learning process. Primary school students (N = 40; 6.3 years) participated in this study. They were divided into two groups: an experimental group (20 students) and a control group (20 students). The first group followed a 12-week motors activity program with 5 sessions of 40 minutes per week and the second a regular math sessions program. The results of the experimental group show a clear improvement in most of the study variables. Also, these results highlight the value of actively involving the student in the task and the importance of using active methods in the teaching-learning process. Article visualizations:
Empowering Chinese Language Learners from Low-Income Families to Improve Their Chinese Writing with ChatGPT’s Assistance Afterschool

ChatGPT is a state-of-the-art generative artificial intelligence (AI) chatbot released by OpenAI in 2022. It simulates human conversation and has the capability to generate different texts at various levels of sophistication in near real time depending upon the user’s skill in creating prompts. While concerns have been raised about academic dishonesty and cheating among students, ChatGPT has significant academic potential for education, particularly in the field of language learning. This research explores the potential of ChatGPT in supporting and empowering Chinese language learners (CLLs) whose first language is English to enhance their writing skills, mainly focusing on the research question: Is there a functional relation between Chinese language learners from low‐income families using ChatGPT after school twice a week and improvements in their Chinese writing? Four participants with varying language proficiency levels were recruited, and their data were analyzed using an ABA design. Over three weeks, they utilized ChatGPT twice a week for approximately 20 min each after school. The students’ writing scores, writing samples, and learning reflections were used to triangulate the data and enhance the data’s trustworthiness. The findings indicate that (1) each participant made a noticeable improvement in their Chinese writing scores during the intervention and reversal phases; (2) ChatGPT played a crucial role in correcting errors and facilitating the development of complete sentence structures; and (3) the students expressed a sense of empowerment through their interactions with ChatGPT. These findings highlight that ChatGPT shows promise as a supportive tool for CLLs from low-income families, reducing educational inequality and promoting equitable access to language learning opportunities.
Monitoring the Atlantic Meridional Overturning Circulation at 26.5°N: RAPID-WATCH

The Atlantic Meridional Overturning Circulation (AMOC) at 26.5°N carries a northward heat flux of 1.3 PW. Northward of 26.5°N over the Gulf Stream and its extension much of this heat is transferred to the atmosphere and subsequently is responsible for maintaining UK climate about 5°C warmer than the zonal average at this latitude. However, previous sparse observations did not resolve the temporal variability of the AMOC and so it is unknown whether it is slowing in response to global warming as suggested by recent model results. In 2004 NERC, NSF and NOAA funded a system of observations in the Atlantic at 26.5°N to observe on a daily basis the strength and structure of the AMOC. Two papers ([Cunningham, et al., 2007] & [Kanzow, et al., 2007]) demonstrated that not only does the system of observations achieve a mass balance for the AMOC, it reveals dramatic and unexpected richness of variability. In the first year the AMOC mean strength and variability is 18.7±5.6 Sv. From estimates of the degrees-of-freedom the year-long mean AMOC is defined with a resolution of around 1.5 Sv so abrupt changes would be readily identified and long-term changes will be measured relative to the 2004-2005 average. The NERC contribution to the first four years of continuous AMOC observations was funded under the directed programme RAPID Climate Change. Following an international review of the system NERC will continue funding to 2014 under the programme RAPID-WATCH. The NSF and NOAA have also continued funding and commitments so that the system can continue operating at the same level of activity as during the period 2004-2008. The objectives of RAPID-WATCH are: To deliver a decade-long time series of calibrated and quality-controlled measurements of the Atlantic MOC from the RAPID-WATCH arrays and; To exploit the data from the RAPID-WATCH arrays and elsewhere to determine and interpret recent changes in the Atlantic MOC, assess the risk of rapid climate change, and investigate the potential for predictions of the MOC and its impacts on climate.
Impact of the 2008 Sichuan Earthquake on China's stock market: As an example to the "Chenyu Plate" of China

The stock market ont only meet with the macro-economic impact, but also with a number of unexpected events' influences. May 12 Wenchuan earthquake had a short-term impact on the stock market. Some companies' stocks suspended and significantly increased. It caused 66 listed companies' stocks with effect from the suspension, 45 listed companies suspended. Medicine, agriculture and cement stocks rose overall, more than 40 pharmaceutical stocks raised limit. For long-term impact, we use GARCH model and analysis the long-term impact on stock mark. The result shows that the earthquake has not changed the basic level of China's stock market, the time of continuity and fluctuations are short and the long-term impact on China's stock market is limited. (Xie Yong-gang, Guo Xin-li, Dang Peng, Xie Bo-wen, Impact of the 2008 Sichuan Earthquake on China's stock market: As an example to the "Chenyu Plate" of China, World Rural Observations 2011;3(1):97-108). ISSN: 1944-6543 (print); ISSN: 1944-6551 (online). http://www.sciencepub. net/rural.
PTEN-induced kinase 1 exerts protective effects in diabetic kidney disease by attenuating mitochondrial dysfunction and necroptosis

Mitochondrial dysfunction plays a pivotal role in diabetic kidney disease initiation and progression. PTEN-induced serine/threonine kinase 1 (PINK1) is a core organizer of mitochondrial quality control; however, its function in diabetic kidney disease remains controversial. Here, we aimed to investigate the pathophysiological roles of PINK1 in diabetic tubulopathy, focusing on its effects on mitochondrial homeostasis and tubular cell necroptosis, which is a specialized form of regulated cell death. PINK1-knockout mice showed more severe diabetes-induced tubular injury, interstitial fibrosis, and albuminuria. The expression of profibrotic cytokines significantly increased in the kidneys of diabetic Pink1-/- mice, which eventually culminated in aggravated interstitial fibrosis. Additionally, the knockdown of PINK1 in HKC-8 cells upregulated the fibrosis-associated proteins, and these effects were rescued by PINK1 overexpression. PINK1 deficiency was also associated with exaggerated hyperglycemia-induced mitochondrial dysfunction and defective mitophagic activity, whereas PINK1 overexpression ameliorated these negative effects and restored mitochondrial homeostasis. Mitochondrial reactive oxygen species triggered tubular cell necroptosis under hyperglycemic conditions, which was aggravated by PINK1 deficiency and improved by its overexpression. In conclusion, PINK1 plays a pivotal role in suppressing mitochondrial dysfunction and tubular cell necroptosis under high glucose conditions and exerts protective effects in diabetic kidney disease.
Using the Anna Karenina Principle to explain why cause favors negative-sentiment complements

This paper sets out to explain why the verb cause tends to occur with negative-sentiment complements ( cause damage, cause problems ), as observed by Stubbs (1995). Formalized using causal models (Pearl 2000, Halpern & Pearl 2005, Schulz 2011), the analysis hinges on the asymmetric inference patterns licensed by necessary versus sufﬁcient causes in the common scenario where some variables in a causal model remain uncertain. States of certainty/uncertainty are captured by subdividing the traditional deﬁnitions of necessity and sufﬁciency into a local version (all other variables ﬁxed at particular values) and a global version (all other variables unsettled). C causes E is argued to entail that C is locally sufﬁcient for E , and to implicate that C is at least possibly locally necessary for E . With this deﬁnition, it is shown that C causes E can be truthfully applied to more uncertain contexts when C is a globally sufﬁcient cause of E rather than a globally necessary one. Cause thus tends to occur with outcomes depending on a single globally sufﬁcient cause — outcomes which are moreover shown to be negative in sentiment, reﬂecting the independently motivated “Anna Karenina Principle” that bad outcomes tend to require single sufﬁcient causes, thus indirectly explaining why cause prefers negative-sentiment complements. The meaning and collocational sentiment of cause are used to illuminate one another.
mt-tRNAs in the polymerase gamma mutant heart

Introduction: Mice harboring a D257A mutation in the proofreading domain of the mitochondrial DNA polymerase, Polymerase Gamma (POLG), experience severe metabolic dysfunction and display hallmarks of accelerated aging. We previously reported a mitochondrial unfolded protein response (UPTmt) - like (UPRmt-like) gene and protein expression pattern in the right ventricular tissue of POLG mutant mice. Aim: We sought to determine if POLG mutation altered the expression of genes encoded by the mitochondria in a way that might also reduce proteotoxic stress. Methods and Results: The expression of genes encoded by the mitochondrial DNA was interrogated via RNA-seq and northern blot analysis. A striking, location-dependent effect was seen in the expression of mitochondrial-encoded tRNAs in the POLG mutant as assayed by RNA-seq. These expression changes were negatively correlated with the tRNA partner amino acid’s amyloidogenic potential. Direct measurement by northern blot was conducted on candidate mt-tRNAs identified from the RNA-seq. This analysis confirmed reduced expression of MT-TY in the POLG mutant but failed to show increased expression of MT-TP, which was dramatically increased in the RNA-seq data. Conclusion: We conclude that reduced expression of amyloid-associated mt-tRNAs is another indication of adaptive response to severe mitochondrial dysfunction in the POLG mutant. Incongruence between RNA-seq and northern blot measurement of MT-TP expression points towards the existence of mt-tRNA post-transcriptional modification regulation in the POLG mutant that alters either polyA capture or cDNA synthesis in RNA-seq library generation. Together, these data suggest that 1) evolution has distributed mt-tRNAs across the circular mitochondrial genome to allow chromosomal location-dependent mt-tRNA regulation (either by expression or PTM) and 2) this regulation is cognizant of the tRNA partner amino acid′s amyloidogenic properties.
Ionizing Radiation Synthesis of Hydrogel Nanoparticles of Gelatin and Polyethylene Glycol at High Temperature

Nanohydrogel particles of polyethylene glycol (PEG), gelatin (GEL), and PEG–GEL mixtures (MIXs) were synthesized with a high electron beam and 60Co gamma-ray radiation. The relatively novel technique of Asymmetrical Flow Field Flow Fractionation (AF4 or AFFFF) coupled to a Multi-Angle Laser Light Scattering (MALLS) detector was mainly used to determine the hydrodynamic diameter (Dh) of the radiation-synthesized PEG, GEL, and PEG–GEL nanohydrogel particles. Our approach to achieving nanohydrogel particles is to enhance the intracrosslinking reactions and decrease the intercrosslinking reactions of the C-centered radicals of the PEG and GEL. The intracrosslinking reactions of these free radicals were enhanced via irradiation at temperatures of 77–80 °C and using a high dose rate and pulsed irradiation. The shorter average distance between the C-centered free radicals on the backbone of the thermally collapsed PEG and GEL chain, due to the destruction of hydrogen bonds, enhances the intracrosslinking reactions. It was observed that increasing the dose and dose rate decreased the Dh. DLS results lined up with AF4 measurements. This study provides researchers with a clean method to produce GEL–PEG hydrogels without the use of toxic reagents. Particle size can be tuned with dose, dose rate, and temperature as demonstrated in this work. This is ideal for medical applications as the use of ionizing radiation eliminates toxicity concerns and provides simultaneous sterilization of the material.
Identifying Soil Hydraulic Heterogeneity by Detection of Relative Change in Passive Microwave Remote Sensing Observations

The ability of passive microwave remote sensing (PMRS) to assess soil moisture has been amply demonstrated. Building on the expertise, this research is a first attempt at obtaining near-surface soil hydraulic characteristics from PMRS. We show that relative change in surface soil moisture can be determined accurately from PMRS measurements of brightness temperature, given the commonly observed linear relationship between the two variables. Relative, rather than absolute, change within a series of PMRS images, obtained during a period of drying, is also a very useful statistic for filtering out the drydown heterogeneity caused by spatial variability in initial wetness rather than soil heterogeneity. We develop a test of soil heterogeneity based on the detection of deviations of relative change from the average rate in a series of images by more than the instrument error. With the test, the existence of soil heterogeneity for a pair of images showing a drydown during the 1992 Hydrologic Atmospheric Pilot Experiment (HAPEX-Sahel) experiment can be proven. Areas of relatively fast or slow drying can be mapped. These areas coincide with geomorphological features and soil-type patterns that are expected to show the observed moisture dynamics. The variogram of relative change in the HAPEX images differs from those of brightness temperature, corroborating the rejection of the soil homogeneity hypothesis. Furthermore, the variogram indicates the existence of an effective correlation length much larger than that commonly observed in ground-based soil surveys. These findings encourage the use of PMRS for assessing soil hydraulic characteristics that are valid at a scale appropriate for hydrometeorological models.
Theranostics with photodynamic therapy for personalized medicine: to see and to treat

Photodynamic Therapy (PDT) is an approved treatment modality, which is presently receiving great attention due to its limited invasiveness, high selectivity and limited susceptibility to drug resistance. Another related research area currently expanding rapidly is the development of novel theranostic agents based on the combination of PDT with different imaging technologies, which allows for both therapy and diagnosis. This combination can help to address issues of suboptimal biodistribution and selectivity through regional imaging, while therapeutic agents enable an effective and personalized therapy. In this review, we describe compounds, whose structures combine PDT photosensitizers with different imaging probes - including examples for near-infrared optical imaging, magnetic resonance imaging (MRI) and nuclear imaging (PET or SPECT), generating novel theranostic drug candidates. We have intentionally focused our attention on novel compounds, which have already been investigated preclinically in vivo in order to demonstrate the potential of such theranostic agents for clinical applications.
Quercetin ameliorates ferroptosis of rat cardiomyocytes via activation of the SIRT1/p53/SLC7A11 signaling pathway to alleviate sepsis-induced cardiomyopathy

Sepsis-induced cardiomyopathy (SIC) is a manifestation of multiple organ failure as a result of sepsis and is a serious threat to life. Here, the effect and mechanisms of quercetin (QUE) in SIC were assessed. It was found that patients with SIC expressed lower serum levels of glutathione peroxidase 4 (GPX4) and SIRT1 but higher levels of CK-MB, cTnI, TNF-α, and IL-6 compared with healthy individuals. A dose of 80 μM QUE increased the viability and reduced the ferroptosis of H9C2 cells treated with 1.0 μg/ml LPS in vitro. The administration of QUE decreased the levels of MDA, NADPH, lipid peroxidation and cytoplasmic cytochrome C and upregulated the levels of GSH and TOM 20, thus exerting an anti-oxidative effect via mediating SIRT1 expression. It also activated the SIRT1/p53/SLC7A11 signaling pathway to reduce cellular Fe2+ and PTGS2 levels, decreased cell apoptosis rate, and upregulated the levels of GPX4 and ferritin to inhibit ferroptosis of H9C2 cells in vitro. Injection of QUE into rats activated the SIRT1/p53/SLC7A11 signaling pathway, reduced the levels of CK-MB, cTnI, inflammatory cell infiltration, MDA, NADPH, cytoplasmic cytochrome C, cellular Fe2+, and PTGS2 but upregulated the levels of GSH, TOM 20, GPX4, and ferritin to alleviate SIC in a dose-dependent manner in vivo. To conclude, QUE exerted an anti-ferroptotic effect via activation of the SIRT1/p53/SLC7A11 signaling pathway to dampen SIC both in vivo and in vitro. These findings highlighted a potential therapeutic strategy for the management of SIC.
Investigating Antibody Reactivity to the Intestinal Microbiome in Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Feasibility Study

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystemic disease of unknown aetiology that is characterised by disabling chronic fatigue and involves both the immune and gastrointestinal (GI) systems. Patients display alterations in GI microbiome with a significant proportion experiencing GI discomfort and pain and elevated blood biomarkers for altered intestinal permeability compared with healthy individuals. To investigate a possible GI origin of ME/CFS we designed a feasibility study to test the hypothesis that ME/CFS pathogenesis is a consequence of increased intestinal permeability that results in microbial translocation and a breakdown in immune tolerance leading to generation of antibodies reactive to indigenous intestinal microbes. Secretory immunoglobulin (Ig) A and serum IgG levels and reactivity to intestinal microbes were assessed in five pairs of severe ME/CFS patients and matched same-household healthy controls. For profiling serum IgG, we developed IgG-Seq which combines flow-cytometry based bacterial cell sorting and metagenomics to detect mucosal IgG reactivity to the microbiome. We uncovered evidence for immune dysfunction in severe ME/CFS patients that was characterised by reduced capacity and reactivity of serum IgG to stool microbes, irrespective of their source. This study provides the rationale for additional studies in larger cohorts of ME/CFS patients to further explore immune–microbiome interactions.
Drastic Microbial Count Reduction in Soy Milk Using Continuous Short-Wave Ultraviolet Treatments in a Tubular Annular Thin Film UV-C Reactor

Vegetative cells of Listeria monocytogenes and Escherichia coli and spores of Bacillus subtilis and Aspergillus niger were inoculated in soy milk at an initial concentration of ≈5 log CFU/mL. Inoculated and control (non-inoculated) soy milk samples were submitted to three types of treatments using a tubular annular thin film short-wave ultraviolet (UV-C) reactor with 1 mm of layer thickness. Treatments applied depended on the flow rate and the number of entries to the reactor, with UV-C doses ranging from 20 to 160 J/mL. The number of entries into the reactor tube (NET) was established as the most determining parameter for the efficiency of the UV-C treatments. Conidiospores of A. niger were reported as the most resistant, followed by B. subtilis spores, while vegetative cells were the most sensible to UV-C, with Listeria monocytogenes being more sensible than Escherichia coli. Treatments of just 80 J/mL were needed to achieve a 5 log CFU/mL reduction of L. monocytogenes while 160 J/mL was necessary to achieve a similar reduction for A. niger spores.