Miracle-dz/UniFAR-FTUs huggingface dataset:
TITLE : INVESTIGATING THE INFLUENCE OF SYNOPTIC-SCALE 1 METEOROLOGY ON AIR QUALITY USING SELF-ORGANIZING MAPS AND 2 GENERALIZED ADDITIVE MODELLING

29 The influence of synoptic-scale circulations on air quality is an area of increasing interest to 30 air quality management in regards to future climate change. This study presents an analysis 31 where the dominant synoptic " types " over the region of Melbourne, Australia are determined 32 and linked to regional air quality. First, a self-organising map (SOM) is used to generate a 33 time series of synoptic charts that classify the annual daily circulation affecting Melbourne 34 into 20 different synoptic types. SOM results are then employed within the framework of a 35 generalized additive model (GAM) to identify links between synoptic-scale circulations and 36 observed changes air pollutant concentrations. The GAMs estimate shifts in pollutant 37 concentrations under each synoptic type after controlling for long-term trends, seasonality, 38 weekly emissions, spatial variation, and temporal persistence. Results showed the aggregate 39 impact of synoptic circulations in the models to be quite modest as only 5.1% of the daily 40 variance in O 3 , 4.7% in PM 10 , and 7.1% in NO 2 were explained by shifts in synoptic 41 circulations. Further analysis of the partial residual plots identified that despite a modest 42 response at the aggregate level, individual synoptic categories had differential effects on air 43 pollutants. In particular, increases of up to 40% in NO 2 and PM 10 and 30% in O 3 occur when 44 a synoptic conditions result in a north-easterly gradient wind over the Melbourne area. 45 Additionally, NO 2 and PM 10 levels also showed increases of up to 40% when a strong high 46 pressure system was centered directly over the Melbourne area. In sum, the unified approach 47 of SOM and GAM proved to be a complementary suite of tools capable of identifying the 48 entire range synoptic circulation patterns over a particular region and quantifying how they 49 influence local air quality.
HAMP Domain Rotation and Tilting Movements Associated with Signal Transduction in the PhoQ Sensor Kinase

ABSTRACT HAMP domains are α-helical coiled coils that often transduce signals from extracytoplasmic sensing domains to cytoplasmic domains. Limited structural information has resulted in hypotheses that specific HAMP helix movement changes downstream enzymatic activity. These hypotheses were tested by mutagenesis and cysteine cross-linking analysis of the PhoQ histidine kinase, essential for resistance to antimicrobial peptides in a variety of enteric pathogens. These results support a mechanistic model in which periplasmic signals which induce an activation state generate a rotational movement accompanied by a tilt in α-helix 1 which activates kinase activity. Biochemical data and a high-confidence model of the PhoQ cytoplasmic domain indicate a possible physical interaction of the HAMP domain with the catalytic domain as necessary for kinase repression. These results support a model of PhoQ activation in which changes in the periplasmic domain lead to conformational movements in the HAMP domain helices which disrupt interaction between the HAMP and the catalytic domains, thus promoting increased kinase activity. IMPORTANCE Most studies on the HAMP domain signaling states have been performed with chemoreceptors or the HAMP domain of Af1503. Full-length structures of the HAMP-containing histidine kinases VicK and CpxA or a hybrid between the HAMP domain of Af1503 and the EnvZ histidine kinase agree with the parallel four-helix bundle structure identified in Af1503 and provide snapshots of structural conformations experienced by HAMP domains. We took advantage of the fact that we can easily regulate the activation state of PhoQ histidine kinase to study its HAMP domain in the context of the full-length protein in living cells and provide biochemical evidence for different conformational states experienced by Salmonella enterica serovar Typhimurium PhoQ HAMP domain upon signaling. Most studies on the HAMP domain signaling states have been performed with chemoreceptors or the HAMP domain of Af1503. Full-length structures of the HAMP-containing histidine kinases VicK and CpxA or a hybrid between the HAMP domain of Af1503 and the EnvZ histidine kinase agree with the parallel four-helix bundle structure identified in Af1503 and provide snapshots of structural conformations experienced by HAMP domains. We took advantage of the fact that we can easily regulate the activation state of PhoQ histidine kinase to study its HAMP domain in the context of the full-length protein in living cells and provide biochemical evidence for different conformational states experienced by Salmonella enterica serovar Typhimurium PhoQ HAMP domain upon signaling.
Successful Product Line Engineering: A Case Study1

The economics of software motivates approaches to reduce the cost of development and life-cycle maintenance of software systems. One approach to reducing cost is to create a product line, a group of similar products structured to take advantage of each other’s assets. Product lines epitomize reuse. Experience is showing that a technical approach alone is not sufficient to produce a successful product line production capability. Factors such as economic, organizational, managerial, and process, play a crucial role in establishing and maintaining a product line. This presentation reports on the experience of CelsiusTech Systems, a Swedish naval defense contractor, that has succeeded in adopting a product line approach. 1. What is a Product Line? During the early days of computer programming, computers were expensive and software was, by comparison, cheap. That situation is no longer the case. Software is usually the most expensive component of an operational computer system. Even if the computer is part of a larger system, such as an aircraft or a nuclear power plant, the cost of the software is a significant, if not overwhelming, factor. The economics of software motivates approaches to reduce the cost of development, deployment, and life-cycle maintenance of software systems. One approach to reducing cost is to amortize the investment across more than one system. Kolter [1] defines a product line from a marketing view point as a group of similar products within a market segment (or mission domain). Meyers [2] defines a product family as a set of products that share a common design and standards (or assets). A product line built from product family assets maximizes reuse yielding economies of production. Our references to product lines through the remainder of this report subscribes to this combined definition. Product lines can maximize the reuse of a wide variety of assets, such as requirements, the analysis of the system and software requirements, the overall system and 1. This work is sponsored by the U.S. Department of Defense. Presented at the Software Technology Conference, Salt Lake City, April 1996.
Testosterone and Context-Specific Risk: Digit Ratios As Predictors of Recreational, Financial, and Social Risk-Taking Proclivity

• Dependent variables: • Domain-specific risk-taking behavior scale [12]. • Each domain contained 10 five-point Likerttype items (1 to 5) assessing one‟s likelihood of engaging in a given risky activity (all alphas above .67): • Recreational • “periodically engaging in a dangerous sports (e.g., mountain climbing or sky diving)” • Financial • “investing 10% of your annual income in a very speculative stock”) • Social • “speaking your mind about an unpopular issue at a social occasion”) • Ethical • “shoplifting a small item (e.g., a lipstick or pen)” • Health • “eating „expired‟ food products that still „look okay‟ ” 1) Research Question
A high-efficiency back-bias generator with cross-coupled hybrid pumping circuit for sub-1.5 V DRAM applications

Based on the study about the previously developed back-bias generators, a new high-efficiency back-bias generator with the Cross-coupled Hybrid Pumping Circuit 2 (CHPC2) is presented in this paper. CHPC2 takes only the advantages from the previous ones, throwing away the disadvantages. CHPC2 shows |VBB|/VCCas large as 98% even at low VCC=0.9 V, strongly addressing that it will be suitable at low voltage DRAM applications. Moreover, CHPC2 exhibits much better pumping efficiency and larger pumping current over the previous ones with wide RLrange at VCC=1.2 V.
Prevalence of Ventricular Premature Complexes in Healthy and Untreated Hypertensive Elderly People

Twenty-four-hour ambulatory electrocardiographic examination was per formed in 130 elderly patients (49 healthy, active subjects; 40 hypertensive with out left ventricular hypertrophy; and 41 hypertensive with left ventricular hypertrophy). In the study group, mean age was 72.4±7.1 (sixty-five to eighty- eight) years. A significantly high prevalence of ventricular ectopic complexes was found both in hypertensive and in normotensive groups. According to the Lown grades, in grade 1, VPCs had very high prevalence in healthy subjects, in grade 2, VPCs had a high prevalence in hypertensives with left ventricular hy pertrophy (73.5% and 48.8%, respectively). The results of this study demon strate that ventricular premature complexes were common in hypertensive patients and healthy elderly but did not cause high complexity in either group. Ventricular premature complexes detected by ambulatory ECG monitoring in healthy, active subjects and in untreated hypertensive patients are not an inde pendent risk factor in elderly patients.
ARF Function Does Not Require p53 Stabilization or Mdm2 Relocalization

ABSTRACT It is generally accepted that the ARF tumor suppressor induces p53-dependent growth arrest by sequestering the p53 antagonist Mdm2 in the nucleolus. Previous mutagenic studies of murine ARF suggested that residues 1 through 14 and 26 through 37 were critical for Mdm2 binding, while the latter domain also governed ARF nucleolar localization. We show that mouse ARF residues 6 to 10 and 21 to 25 are required for ARF-induced growth arrest whereas residues 1 to 5 and 29 to 34 are dispensable. Deletion of the putative nucleolar localization signal 31RRPR34 did not prevent nucleolar localization. Surprisingly, unlike wild-type ARF, growth-inhibitory mutants D1-5 and D29-34 failed to stabilize p53 yet induced its transcriptional activation in reporter assays. This suggests that p53 stabilization is not essential for ARF-mediated activation of p53. Like wild-type ARF, both mutants also exhibited p53-independent function since they were able to arrest p53/Mdm2-null cells. Notably, other mutants lacking conserved residues 6 to 10 or 21 to 25 were unable to suppress growth in p53-positive cells despite nucleolar localization and the ability to import Mdm2. Those observations stood in apparent contrast to the ability of wild-type ARF to block growth in some cells without relocalizing endogenous Mdm2 to nucleoli. Together, these data show a lack of correlation between ARF activity and Mdm2 relocalization, suggesting that additional events other than Mdm2 import are required for ARF function.
Arrhythmogenic right ventricular cardiomyopathy.

Arrhythmogenic disorders of genetic origin include structural cardiomyopathies and inherited arrhythmic syndromes.1 Arrhythmogenic right ventricular cardiomyopathy (ARVC) is listed among the former, because it is characterized by structural and functional abnormalities of the right ventricle (RV), ranging from regional wall motion abnormalities and aneurysms to global dilation and dysfunction, with or without left ventricular involvement.2–4 The clinical picture is usually dominated by ventricular arrhythmias, even at risk of sudden cardiac death in young people during effort,5–7 thus justifying the adjective arrhythmogenic. However, it recently has been emphasized that in the early stages (concealed phase) the disease can resemble ion channel diseases, such as long QT and Brugada syndromes, because it can carry the risk of ventricular arrhythmias before the onset of overt structural abnormalities. Thus, early diagnosis and risk stratification pose major clinical challenges with the natural history of ARVC. ARVC is a relatively recent nosologic entity when compared with other inherited arrhythmogenic disorders, such as hypertrophic cardiomyopathy or long QT syndrome. However, after the identification of the first disease-causing gene,8 many steps forward have been made in the knowledge of its molecular background, which led to the current belief of a genetically determined cardiomyopathy.9 In the 1990s, the difficulty in determining affected members in ARVC family trees, mostly because of the variable penetrance and the low sensitivity of diagnostic criteria, represented the major obstacle for linkage analysis and candidate gene studies. The first ARVC-causing gene (ie, JUP-encoding plakoglobin) was identified only in 2000 in a fully penetrant, autosomal-recessive syndrome, previously mapped on chromosome 17, and characterized by an easily recognizable cardiocutaneous phenotype, ie, the Naxos syndrome.8,10 In the same year, a recessive mutation of the gene DSP-encoding desmoplakin was found to cause a similar cardiocutaneous phenotype, ie, …
Psychosocial Predictors of Treatment Outcome, Dropout, and Change Processes in a Pharmacological Clinical Trial for Alcohol Dependence

ObjectivesThe purpose of this study was to examine psychosocial variables associated with treatment outcome, dropout, and the change process in a clinical trial that combines pharmacotherapy with a psychosocial intervention. MethodsParticipants (N=72) were men and women who enrolled in a 12-week clinical trial of olanzapine for alcohol dependence. All participants received 2 individual sessions of a motivation-based intervention. ResultsAnalysis revealed that higher motivation for change and higher problem severity were individually associated with lower rates of treatment dropout. The effects of problem severity on treatment dropout were found to be mediated by motivation for change. Regarding treatment outcome, baseline measures of craving for alcohol significantly predicted drinking outcomes during follow-up. Furthermore, changes in craving for alcohol before and after treatment were found to predict drinking outcomes at follow-up. ConclusionsResults are discussed in terms of their implications for the treatment of alcohol dependence, particularly regarding clinical trials that combine pharmacotherapy with a psychosocial intervention.
Visual tracking and control of Unmanned Aerial Vehicle

In this study, we perform target detection and tracking with Unmanned Aerial Vehicle (UAV) as well as the visual command of UAV. Our goal is to develop an autopilot system to reduce the human factor in UAV's. We create a system that follows different objects, stays locked to a graphical object which is glyph that has an encryption that only we describe, and executes the mission encoded on glyph in both indoor and outdoor tests. We obtain the targeting by the angle and the dimensions of the glyph. We've obtained successful results in applied presentations.
Examples of using technology in teaching Human—Computer Interaction according to the Bologna process

The abundance of information and communication technology and especially internet services demands changes in lecturerspsila head-on teaching methods towards new directives. This article presents some examples of human-centred use of information technology, applied in the subject of human-computer interaction. Examples include the open source learning management system moodle, video based lecturing, remote laboratory of intelligent house and an age simulator - AgeSim. This article presents the planning and execution of teaching processes with use of Moodle Web tools and exposes organizational structure as well as characteristics, which appeared during the learning process. Finally we show some benefits and weaknesses that arose during the use of the Moodle environment.
injurious ventilation in rats Pulmonary impedance and alveolar instability during

You might find this additional information useful. This article cites 48 articles, 33 of which you can access free at: http://jap.physiology. org/cgi/content/full/99/2/723#BIBL Updated information and services including high-resolution figures, can be found at: http://jap.physiology. org/cgi/content/full/99/2/723 Additional material and information about Journal of Applied Physiology can be found at: http://www.the-aps.org/publications/jappl This information is current as of July 26, 2005 . € ISSN: 8750-7587, ESSN: 1522-1601. Visit our website at http://www.the-aps.org/.
EPHA2 Is Associated with Age-Related Cortical Cataract in Mice and Humans

Age-related cataract is a major cause of blindness worldwide, and cortical cataract is the second most prevalent type of age-related cataract. Although a significant fraction of age-related cataract is heritable, the genetic basis remains to be elucidated. We report that homozygous deletion of Epha2 in two independent strains of mice developed progressive cortical cataract. Retroillumination revealed development of cortical vacuoles at one month of age; visible cataract appeared around three months, which progressed to mature cataract by six months. EPHA2 protein expression in the lens is spatially and temporally regulated. It is low in anterior epithelial cells, upregulated as the cells enter differentiation at the equator, strongly expressed in the cortical fiber cells, but absent in the nuclei. Deletion of Epha2 caused a significant increase in the expression of HSP25 (murine homologue of human HSP27) before the onset of cataract. The overexpressed HSP25 was in an underphosphorylated form, indicating excessive cellular stress and protein misfolding. The orthologous human EPHA2 gene on chromosome 1p36 was tested in three independent worldwide Caucasian populations for allelic association with cortical cataract. Common variants in EPHA2 were found that showed significant association with cortical cataract, and rs6678616 was the most significant in meta-analyses. In addition, we sequenced exons of EPHA2 in linked families and identified a new missense mutation, Arg721Gln, in the protein kinase domain that significantly alters EPHA2 functions in cellular and biochemical assays. Thus, converging evidence from humans and mice suggests that EPHA2 is important in maintaining lens clarity with age.
Critical Trauma Studies: Understanding Violence, Conflict, and Memory in Everyday Life

Dr. Christopher Powell is the author of Barbaric Civilization: A Critical Sociol- ogy of Genocide , and is co-editor, with François Dépelteau, of Conceptualizing Relational Sociology: Ontological and Theoretical Issues and Applying Relational Sociology: Relations, Networks, and Society . His current research interests address the social circulation of shame, negotiations of deep epistemic differ-ence, and the nonintentional dynamics of cooperative decisionmaking.
A control method for timed distributed continuous Petri nets

A timed distributed continuous Petri net system (DcontPN) is composed of several subsystems which communicate through channels modeled by places. In this work, a reachability control problem for DcontPNs composed of two subsystems is considered. An algorithm is developed to calculate the control inputs for each subsystem. The application of the obtained control inputs drives the subsystems from the initial states to the target states in a finite amount of time. The algorithm allows the subsystems to reach their respective target markings at different time instants and keep them as long as required.
Estimation of the Intrinsic Dimension of Hyperspectral Images: Comparison of Current Methods

The intrinsic dimension (ID) of a hyperspectral image (HSI) is an important prior knowledge for unsupervised unmixing. Incorrect determination of this number may have adverse effects on the unmixing results. Several methods have been developed to determine the ID, including Harsanyi-Farrand-Chang (HFC), Hysime, and random matrix theory (RMT). Previous work has shown that real HSI images could contain a certain amount of spectrally correlated noise, and noise approximation as well as ID estimation would suffer from it. This paper compares the performance of ID estimation methods with respect to various noise approximation methods, types of data, and parameters such as noise levels and correlation, noise approximation methods, and number of endmembers. It shows that a significant improvement can be obtained with most ID estimation methods by adapting them to the case where spectral correlation in the noise is considered as well.
Women Have to Enter the Leadership Race to Win: Using Random Selection to Increase the Supply of Women into Senior Positions

Despite well-intentioned efforts, the supply of women into senior management roles has changed little. Radical ideas are apparently needed. This paper is an attempt to suggest one. It is to use a form of random selection of candidates – drawn from a pre-selected and properly qualified pool – to increase the supply of women into management positions. The background rationale is that while most gender studies have focused on the demand side (direct and indirect discrimination), we think about how to improve the supply side, and in particular how to find ways to reduce negative self-stereotypes and stereotype threats. Evidence suggests, for example, that women shy away from competition, and are especially averse to rejection. We argue that a random-draw method would offer women a type of ‘rejection insurance’, lessen the ‘chosen one’ factor associated with leadership, prevent the desire for a ‘safe pair of hands’ (i.e. a man), and foster genuine equality.
Allie: a database and a search service of abbreviations and long forms

Many abbreviations are used in the literature especially in the life sciences, and polysemous abbreviations appear frequently, making it difficult to read and understand scientific papers that are outside of a reader’s expertise. Thus, we have developed Allie, a database and a search service of abbreviations and their long forms (a.k.a. full forms or definitions). Allie searches for abbreviations and their corresponding long forms in a database that we have generated based on all titles and abstracts in MEDLINE. When a user query matches an abbreviation, Allie returns all potential long forms of the query along with their bibliographic data (i.e. title and publication year). In addition, for each candidate, co-occurring abbreviations and a research field in which it frequently appears in the MEDLINE data are displayed. This function helps users learn about the context in which an abbreviation appears. To deal with synonymous long forms, we use a dictionary called GENA that contains domain-specific terms such as gene, protein or disease names along with their synonymic information. Conceptually identical domain-specific terms are regarded as one term, and then conceptually identical abbreviation-long form pairs are grouped taking into account their appearance in MEDLINE. To keep up with new abbreviations that are continuously introduced, Allie has an automatic update system. In addition, the database of abbreviations and their long forms with their corresponding PubMed IDs is constructed and updated weekly. Database URL: The Allie service is available at http://allie.dbcls. jp/.