Miracle-dz/UniFAR-FTUs huggingface dataset:
Prostate Carcinogenesis with Diabetes and Androgen-Deprivation-Therapy-Related Diabetes: An Update

Prostate cancer and the androgen deprivation therapy (ADT) thereof are involved in diabetes in terms of diabetes-associated carcinogenesis and ADT-related metabolic disorder, respectively. The aim of this study is to systematically review relevant literature. About 218,000 men are estimated to be newly diagnosed with prostate cancer every year in the United States. Approximately 10% of them are still found with metastasis, and in addition to them, about 30% of patients with nonmetastatic prostate cancer recently experience ADT. Population-based studies have shown that dissimilar to other malignancies, type 2 diabetes is associated with a lower incidence of prostate cancer, whereas recent large cohort studies have reported the association of diabetes with advanced high-grade prostate cancer. Although the reason for the lower prevalence of prostate cancer among diabetic men remains unknown, the lower serum testosterone and PSA levels in them can account for the increased risk of advanced disease at diagnosis. Meanwhile, insulin resistance already appears in 25–60% of the patients 3 months after the introduction of ADT, and long-term ADT leads to a higher incidence of diabetes (reported hazard ratio of 1.28–1.44). Although the possible relevance of cytokines such as Il-6 and TNF-α to ADT-related diabetes has been suggested, its mechanism is poorly understood.
Enhanced Adhesion of Continuous Nanoporous Au Layers by Thermochemical Oxidation of Glassy Carbon

The fabrication of a nanoporous gold (NPG)-based catalyst on a glassy carbon (GC) support results normally in large isolated and poorly adhering clusters that suffer considerable material loss upon durability testing. This work exploits thermochemical oxidation of GC, which, coupled with the utilization of some recent progress in fabricating continuous NPG layers using a Pd seed layer, aims to enhance the adhesion to the GC surface. Thermochemical oxidation causes interconnected pores within the GC structure to open and substantially improves the wettability of the GC surface, which are both beneficial toward the improvement of the overall quality of the NPG deposit. It is demonstrated that thermochemical oxidation neither affects the efficiency of the Au0.3Ag0. 7 alloy (NPG precursor) deposition nor hinders the achievement of continuity in the course of the NPG fabrication process. Furthermore, adhesion tests performed by a rotating disk electrode setup on deposits supported on thermochemically-oxidized and untreated GCs ascertain the enhanced adhesion on the thermochemically-oxidized samples. The best adhesion results are obtained on a continuous NPG layer fabricated on thermochemically-oxidized GC electrodes seeded with a dense network of Pd clusters.
The DEAD box RNA helicase VBH‐1 is required for germ cell function in C. elegans

Vasa and Belle are conserved DEAD box RNA helicases required for germ cell function. Homologs of this group of proteins in several species, including mammals, are able to complement a mutation in yeast (DED1) suggesting that their function is highly conserved. It has been proposed that these proteins are required for mRNA translation regulation, but their specific mechanism of action is still unknown. Here we describe functions of VBH‐1, a C. elegans protein closely related to Belle and Vasa. VBH‐1 is expressed specifically in the C. elegans germline, where it is associated with P granules, the C. elegans germ plasm counterpart. vbh‐1(RNAi) animals produce fewer offspring than wild type because of defects in oocyte and sperm production, and embryonic lethality. We also find that VBH‐1 participates in the sperm/oocyte switch in the hermaphrodite gonad. We conclude that VBH‐1 and its orthologs may perform conserved roles in fertility and development. genesis 45:533–546, 2007. © 2007 Wiley‐Liss, Inc.
Isolation and characterization of the Schizosaccharomyces pombe rhp9 gene: a gene required for the DNA damage checkpoint but not the replication checkpoint.

Checkpoint controls exist in eukaryotic cells to ensure that cells do not enter mitosis in the presence of DNA damage or unreplicated chromosomes. In Schizosaccharomyces pombe many of the checkpoint genes analysed to date are required for both the DNA damage and the replication checkpoints, an exception being chk1 . We report here on the characterization of nine new methylmethane sulphonate (MMS)-sensitive S.pombe mutants, one of which is defective in the DNA damage checkpoint but not the replication checkpoint. We have cloned and sequenced the corresponding gene. The predicted protein is most similar to the Saccharomyces cerevisiae Rad9 protein, having 46% similarity and 26% identity. The S.pombe protein, which we have named Rhp9 (Rad9 homologue in S. pombe) on the basis of structural and phenotypic similarity, also contains motifs present in BRCA1 and 53BP1. Deletion of the gene is not lethal and results in a DNA damage checkpoint defect. Epistasis analysis with other S.pombe checkpoint mutants indicates that rhp9 acts in a process involving the checkpoint rad genes and that the rhp9 mutant is phenotypically very similar to chk1.
DBpedia Mobile : A Location-Aware Semantic Web Client

DBpedia Mobile is a location-aware client for the Semantic Web that can be used on an iPhone and other mobile devices. Based on the current GPS position of a mobile device, DBpedia Mobile renders a map indicating nearby locations from the DBpedia dataset. Starting from this map, the user can explore background information about his surroundings by navigating along data links into other Web data sources. DBpedia Mobile has been designed for the use case of a tourist exploring a city. As the application is not restricted to a fixed set of data sources but can retrieve and display data from arbitrary Web data sources, DBpedia Mobile can also be employed within other use cases, including ones unforeseen by its developers. Besides accessing Web data, DBpedia Mobile also enables users to publish their current location, pictures and reviews to the Semantic Web so that they can be used by other Semantic Web applications. Instead of simply being tagged with geographical coordinates, published content is interlinked with a nearby DBpedia resource and thus contributes to the overall richness of the Geospatial Semantic Web.
Elements for prioritizing between conflict resolutions in air traffic control

The new Air Traffic Management concepts rely on high-precision 4-D trajectories, the predictability of which will greatly improve and result in an increase of the efficiency of decision aid tools. This will result in a reduction of air traffic controllerspsila workload through fewer interventions. However, a residual number of conflicts will remain to be managed by controllers. It would be interesting to select, each time it is possible, the conflicts to be handled by the controller rather than by the automated system. On the basis of previous studies, different traffic configurations and resolution types were identified. These were validated using a traffic sample. This validation should be considered preliminary one, due to the traffic data used (27 hours), insufficient compared to the possible sources of variation in relation to the resolution process and workload. However, the results already show some interesting information on how to allocate conflict solving in a future context, when both human and machine will share the task of solving conflicts. This may already contribute to better prioritize in conflict solving, but is mainly a plea for a comprehensive work on this question.
A Coarse-Grained Reconfigurable Processor for Sequencing and Phylogenetic Algorithms in Bioinformatics

A coarse-grained reconfigurable processor tailored for accelerating multiple bioinformatics algorithms is proposed. In this paper, a programmable and scalable architectural platform instantiates an array of coarse grained light weight processing elements, which allows arbitrary partitioning, scheduling schemes and capable of solving complete four popular bioinformatics algorithms: the Needleman-Wunsch, Smith-Waterman, and HMMER on sequencing, and Maximum Likelihood on phylogenetic. The key difference of the proposed CGRA based solution compared to FPGA and GPU based solutions is a much better match on architecture and algorithms for the core computational needs, as well as the system level architectural needs. For the same degree of parallelism, we provide a 5X to 14X speed-up improvements compared to FPGA solutions and 15X to 78X compared to GPU acceleration on 3 sequencing algorithms. We also provide 2.8X speed-up compared to FPGA with the same amount of core logic and 70X compared to GPU with the same silicon area for Maximum Likelihood.
Spatial clustering method for satellite image segmentation

spatial clustering method can be used for the analysis of satellite image to get the meaningful information with the help of fuzzy local information c-means algorithm using image segmentation technique. In previous clustering based image segmentation method may lose the important image details due to the noise present in the satellite image. The effects of noise are avoided by the spatial relationship among pixels, but it often generates boundary zones for the mix of pixel around the edges . To overcome these problem (FELICM) reduces the edge degradation by introducing the weights of pixel within the local neighboring windows. Canny edge detection used for the extraction of edges, during that detection multi-Otsu threshold can be used to obtain two adaptive thresholds. Local neighbors and window center are separated by edge with respect to different weights are set to the windows. Until the final clustering result may be obtained in a efficient manner the pixel of the different local neighbor window periodically iterated. Without any filter preprocessing steps FELICM method can directly applied to the satellite image to get the valuable information when compared to the remote sensing image of a experimental results and not only solves the problem of isolation of samples and random distribution of pixels inside the region but it also produce the high edge accuracies.
Recognition of CDMA signals with orthogonal codes using cyclostationarity

The concept of cyclostationarity can be used for recognition, extraction, and synchronization. A signal exhibits cyclostationarity if its cyclic autocorrelation function (CAF) is non-zero for a non-zero cyclic frequency. The CAF and cyclic frequencies differ from one signal to another depending on their characteristics such as carrier frequency and baud rate. Therefore, the property of cyclostationarity exhibited by modulated signals can be exploited for signal recognition, extraction, and synchronization. In this paper, we employ cyclostationarity for the recognition of CDMA signals that use orthogonal spreading codes. First, we derive an explicit formula for the CAF of such CDMA signals, and then demonstrate how the cyclostationarity in association with the chip rate decreases as the number of multiplexed codes increases. We also show that this cyclostationarity completely disappears if a scrambling code is used together with the spreading code. Furthermore, we consider two cases for enhancing the detection probability: i) the case of antenna diversity and ii) the case when multiple CDMA signals exist in different channels in the same frequency bands. Finally, computer simulations show that the detection probability of a CDMA signal can be improved in the above two cases.
Fault prediction by utilizing self-organizing Map and Threshold

Predicting parts of the programs that are more defects prone could ease up the software testing process, which leads to testing cost and testing time reduction. Fault prediction models use software metrics and defect data of earlier or similar versions of the project in order to improve software quality and exploit available resources. However, some issues such as cost, experience, and time, limit the availability of faulty data for modules or classes. In such cases, researchers focus on unsupervised techniques such as clustering and they use experts or thresholds for labeling modules as faulty or not faulty. In this paper, we propose a prediction model by utilizing self-organizing map (SOM) with threshold to build a better prediction model that could help testers in labeling process and does not need experts to label the modules any more. Data sets obtained from three Turkish white-goods controller software are used in our empirical investigation. The results based on the proposed technique is shown to aid the testers in making better estimation in most of the cases in terms of overall error rate, false positive rate (FPR), and false negative rate (FNR).
Behavioral and Anatomical Correlates of Chronic Episodic Hypoxia during Sleep in the Rat

The role played by chronic episodic hypoxia (EHYP) in the neurocognitive morbidity of obstructive sleep apnea (OSA) is unknown. Sleep recordings, Morris water maze experiments, and immunohistochemistry for NMDA NR1 glutamate receptor, c-fos protein, and apoptosis [nuclear immunoreactivity for single-stranded DNA and terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling assay] were conducted in EHYP-exposed Sprague Dawley male rats. Exposures consisted of up to14 d in an environmental chamber in which O2 concentrations were cycled between 10 and 21% every 90 sec or 30 min during 12 hr of daylight. For the remaining 12 hr, EHYP rats breathed room air, while controls spent 14 d in room air. Although EHYP induced significant disruption of sleep architecture during the initial day of exposure, sleep patterns normalized thereafter. Marked increases in apoptosis occurred in the CA1 hippocampal region (sevenfold) and cortex (Cx; eightfold) after 1–2 d of EHYP but not in CA3 and were followed by decreases toward normoxic levels by 14 d. Double labeling for NMDA NR1 and c-fos revealed marked architectural disorganization in CA1 and Cx with increases in c-fos over time. Rats exposed to EHYP displayed significantly longer escape latencies and swim path lengths to escape a hidden platform during 12 training trials given over 2 d. Differences in the performances of EHYP and control rats, although reduced, persisted after 14 d of recovery. We conclude that EHYP is associated with marked cellular changes over time within neural regions associated with cognitive functions. Furthermore, EHYP impaired performance during acquisition of a cognitive spatial task without affecting sensorimotor function. Such changes may underlie components of the learning and memory impairments found in OSA.
Efficiency analysis of a hydro-pump storage system for frequency support in microgrids

The current paper proposes a comparative study in flux-weakening operation for a permanent magnet synchronous motor (PMSM). This paper considers the operation of a PMSM drive when the speed is changed. The flux-weakening operation which increases or decreases the stator current is obtained by field component. This method allows changing the active power and increasing the efficiency of PMSM, when the current component from q-axis is not changed. Experiments were performed with the help of a laboratory test-bench.
Distributed IMM-Unscented Kalman Filter for Speaker Tracking in Microphone Array Networks

In this paper, we first propose a distributed unscented Kalman filter (DUKF) to overcome the nonlinearity of measurement model in speaker tracking. Next, for the different motion dynamics of a speaker in the in-door environment, we introduce the interacting multiple model (IMM) algorithm and propose a distributed interacting multiple model-unscented Kalman filter (IMM-UKF) for estimating time-varying speaker's positions in a microphone array network. In the distributed IMM-UKF based speaker tracking method, the time difference of arrival (TDOA) of the speech signals received by a pair of microphones at each node is estimated by the generalized cross-correlation (GCC) method, then the distributed IMM-UKF is used to track a speaker whose position and speed significantly vary over time in a microphone array network. The proposed method can estimate speaker's positions globally in the network and obtain a smoothed trajectory of the speaker's movement robustly in noisy and reverberant environments, and it is scalable for speaker tracking. Simulation and real-world experiment results reveal the effectiveness of the proposed speaker tracking method.
Immune reconstitution after allogeneic stem cell transplantation: the impact of stem cell source and graft-versus-host disease.

BACKGROUND AND OBJECTIVES Bone marrow (BM) and blood stem cell (BSC) allografts differ considerably with respect to their content of progenitor cells and progenitor cell subsets as well as mature lymphocytes. The aim of this prospective, randomized study was to determine whether these differences have an impact on early post-transplant immune recovery. DESIGN AND METHODS In a prospective randomised study, we found enhanced immune recovery in recipients of BSC allografts compared to in recipients of BM allografts despite transplantation of a lower number of lymphoid progenitors, particularly B-cell progenitors. The large number of mature lymphocytes in BSC allografts is a plausible explanation for this observation. At the progenitor cell level, we found a comparable and very high proportion of progenitor cells involved in lymphopoiesis in both study groups. RESULTS Patients with extensive chronic GVHD, irrespective of the allograft received, had low immunoglobulin (Ig) levels in serum, low B-cell counts in blood and low numbers of B-cell progenitors in the bone marrow. They also showed high T-cell counts, particularly CD3+CD8+ T-cell counts, which was paralleled by a high number of T-cell progenitors in the bone marrow. In patients with extensive chronic GVHD we found low natural killer (NK)-cell counts which has not been reported previously. INTERPRETATION AND CONCLUSIONS Early immune recovery is enhanced following BSC allografting compared with BM allografting. This is plausibly explained by the large inoculum of mature lymphocytes in BSC allografts. Following allografting, a higher proportion of the BM progenitor cell compartment is involved in lymphopoiesis than it is in healthy adults. However, B-lymphopoiesis is inhibited in patients with extensive chronic GVHD resulting in impaired B-cell recovery. These patients also seem to show impaired NK-cell recovery.
ASSOCIATION OF EPSTEIN-BARR VIRUS (EBV) BUT NOT HUMAN PAPILLOMAVIRUS (HPV) WITH GINGIVITIS AND/OR PERIODONTITIS IN TRANSPLANTED INDIVIDUALS

SUMMARY The aim of this study was to investigate the association of EBV and HPV with gingivitis and/or periodontitis according to the immunologic status. To this end, 74 oral biopsies from transplanted and non-transplanted individuals with the abovementioned oral manifestations were submitted to a screening by PCR for both viruses. According to the results, EBV was strongly associated with gingivitis and/or periodontitis in transplanted individuals (p = 0.011) but not HPV (p = 0.766). EBV-HPV co-detections did not enhance the presence of tissue injury as well. Although a causal relationship was not investigated in this study, the higher frequency of these two oncoviruses in lesion tissues must be investigated in follow-up studies, especially among immunocompromised individuals.
Application of Renormalization Group Method to Kinetic Equations : roles of initial condition (Applications of Renormalization Group Methods in Mathematical Sciences)

The so-called renormalization group (RG) method is applied to derive Boltzmann equation in classical mechanics and Fokker-Planck equation from the respective microscopic equations. Utilizing the formulation of the RG method which elucidates the important role played by the choice of the initial conditions, the general structure and the underlying assumptions in the derivation of kinetic equations in the RG method is clarified.
A software pipelining based VLIW architecture and optimizing compiler

This paper introduces a VLIW architecture and its optimizing compiler which are now under development. Based on the URPR software pipelining approach, the architecture integrates nine PEs with the same structure on a single-chip. In addition, a pipeline register file is used to reduce the inter-body dependent distance to enhance the overlapping of the adjacent loop iterations, furthermore to shorten the length of the optimized loop body. The pipeline register file also increases the bandwidth between PEs. The optimizing compiler is also based on the URPR software pipelining approach. It uses a two-level software pipelining method to implement phase-coupled resource allocation and code optimization, and obtains good time and space optimal results. A compilation example of an FFT innermost loop is discussed. The simulation results indicate that the architecture could reach high performance with the aid of the optimizing compiler. <<ETX>>
Eye Gaze Studies Comparing Head-Up and Head-Down Displays in Vehicles

To minimize the mental workload for the driver and to keep the increasing amount of information easily accessible, sophisticated display and interaction techniques are essential. This contribution focuses on a user-centered analysis for an authoritative grading of head-up displays (HUDs) in cars. Two studies delivered the evaluation data. In a field test, the potential and the usability of the HUD were analyzed. For special driving situations the according display needs and requirements of the users have been identified and compared with in-car displays, so-called head-down displays (HDD). As major result, a high acceptance of the HUD by the driver and a good performance compared to other in-car displays had been reached.
Towards a Tactic-Based Evaluation of Self-Adaptive Software Architecture Availability

nowadays, several non-automatic or semi-automatic software architecture evaluation methods have been proposed to evaluate their quality attributes as availability. In spite of their applicability, they are not effective in self-adaptive software architectures due to their off-line properties; e.g., scenario-based methods. Since the architectural tactics provide a bridge between architectural designs and quality attributes, they have sufficient potential to resolve this problem. In this paper, we assume that the software architecture is completely composed of some architectural patterns. Then we propose an automated evaluation method which composes the architectural tactics and the patterns to measure the availability of software architectures. In this method, the composition of a few availability tactics and patterns are simulated with appropriate probability distribution functions. To predict the availability of patterns, a data mining approach is applied to these simulated models to generate training models for each combination of tactics and patterns. Furthermore, a utility function is defined to compute the availability of systems by these models in O(n) where n is the number of patterns of systems. This method improves the data gathering and analysis activities of the SASSY (Self-Architecting Software SYstems) framework. To validate our method, we have applied it to the Rapidminer case study. KeywordsAvailability, Self-Adaptive Architecture, Architectural Tactic, Architectural Pattern, Data Mining.