Miracle-dz/UniFAR-FTUs huggingface dataset:
Implantation of Bone Marrow Mononuclear Cells Into Ischemic Myocardium Enhances Collateral Perfusion and Regional Function via Side Supply of Angioblasts, Angiogenic Ligands, and Cytokines

Background—Bone marrow implantation (BMI) was shown to enhance angiogenesis in a rat ischemic heart model. This preclinical study using a swine model was designed to test the safety and therapeutic effectiveness of BMI. Methods and Results—BM-derived mononuclear cells (BM-MNCs) were injected into a zone made ischemic by coronary artery ligation. Three weeks after BMI, regional blood flow and capillary densities were significantly higher (4.6- and 2.8-fold, respectively), and cardiac function was improved. Angiography revealed that there was a marked increase (5.7-fold) in number of visible collateral vessels. Implantation of porcine coronary microvascular endothelial cells (CMECs) did not cause any significant increase in capillary densities. Labeled BM-MNCs were incorporated into ≈31% of neocapillaries and corresponded to ≈8.7% of macrophages but did not actively survive as myoblasts or fibroblasts. There was no bone formation by osteoblasts or malignant ventricular arrhythmia. Time-dependent changes in plasma levels for cardiac enzymes (troponin I and creatine kinase-MB) did not differ between the BMI, CMEC, and medium-alone implantation groups. BM-MNCs contained 16% of endothelial-lineage cells and expressed basic fibroblast growth factor≫vascular endothelial growth factor>angiopoietin 1 mRNAs, and their cardiac levels were significantly upregulated by BMI. Cardiac interleukin-1&bgr; and tumor necrosis factor-&agr; mRNA expression were also induced by BMI but not by CMEC implantation. BM-MNCs were actively differentiated to endothelial cells in vitro and formed network structure with human umbilical vein endothelial cells. Conclusions—BMI may constitute a novel safety strategy for achieving optimal therapeutic angiogenesis by the natural ability of the BM cells to secrete potent angiogenic ligands and cytokines as well as to be incorporated into foci of neovascularization.
Effect of morning bright light treatment for rest–activity disruption in institutionalized patients with severe Alzheimer's disease

Background: Disturbances in rest–activity rhythm are prominent and disabling symptoms in Alzheimer's disease (AD). Nighttime sleep is severely fragmented and daytime activity is disrupted by multiple napping episodes. In most institutional environments, light levels are very low and may not be sufficient to enable the circadian clock to entrain to the 24-hour day. The purpose of this randomized, placebo-controlled, clinical trial was to test the effectiveness of morning bright light therapy in reducing rest–activity (circadian) disruption in institutionalized patients with severe AD. Method: Subjects (n=46, mean age 84 years) meeting the NINCDS-ADRDA (National Institute of Neurological and Communicative Disorders and Stroke – the Alzheimer's Disease and Related Disorders Association) AD diagnostic criteria were recruited from two large, skilled nursing facilities in San Francisco, California. The experimental group received one hour (09:30–10:30) of bright light exposure (≥2500lux in gaze direction) Monday through Friday for 10weeks. The control group received usual indoor light (150–200lux). Nighttime sleep efficiency, sleep time, wake time and number of awakenings and daytime wake time were assessed using actigraphy. Circadian rhythm parameters were also determined from the actigraphic data using cosinor analysis and nonparametric techniques. Repeated measures analysis of variance (ANOVA) was used to test the primary study hypotheses. Results and conclusion: Although significant improvements were found in subjects with aberrant timing of their rest–activity rhythm, morning bright light exposure did not induce an overall improvement in measures of sleep or the rest–activity in all treated as compared to control subjects. The results indicate that only subjects with the most impaired rest–activity rhythm respond significantly and positively to a brief (one hour) light intervention.
Methodological practices in cognitive style research: Insights and recommendations from the field of business and psychology

This study provides insights and recommendations concerning methodological practices of cognitive style research applied to the field of business and psychology. Based on a carefully designed selection process, 139 style-related articles published between 1986 and 2010 were content-analysed. In terms of research design, we found the field to be dominated by quantitative, cross-sectional, and single-source designs that relied heavily on self-reports, sample surveys, and student samples. While this might indicate a potential vulnerability in terms of internal and external validity, a strong emphasis on construct validity was also found, exemplified by high attention to reliability, and exploratory and confirmatory factor analyses. With regard to construct measurement, although more than 30 different instruments were used, the field was dominated by three of these. Regarding data analysis, traditional approaches have been mainly used and more advanced and novel approaches have not yet permeated through the cognitive style field. Implications and suggestions for future research are offered. This is the first review of methodological practices in cognitive style research and represents an important step in the advancement of the field.
Self Efficacy, Relapse and the Possibility of Posttreatment Denial as a Stage in Alcoholism

This article reports the results of a study examining self-efficacy and relapse in patients treated in a substance abuse facility for alcoholism. Relapse was measured as a two-stage process of "Lapse" and "Relapse. " The results did not support the previous findings that self-efficacy ratings measured post treatment were valid predictors of treatment outcome status. In examining the results, it is proposed that a condition of "post treatment denial" is operating among patients.
Part I: High-Voltage MOS Device Design for Improved Static and RF Performance

In this paper, for the first time, the key design parameters of a shallow trench isolation-based drain-extended MOS transistor are discussed for RF power applications in advanced CMOS technologies. The tradeoff between various dc and RF figures of merit (FoMs) is carefully studied using well-calibrated TCAD simulations. This detailed physical insight is used to optimize the dc and RF behavior, and our work also provides a design window for the improvement of dc as well as RF FoMs, without affecting the breakdown voltage. An improvement of 50% in RON and 45% in RF gain is achieved at 1 GHz. Large-signal time-domain analysis is done to explore the output power capability of the device.
A Survey of Semantic Segmentation

This survey gives an overview over different techniques used for pixel-level semantic segmentation. Metrics and datasets for the evaluation of segmentation algorithms and traditional approaches for segmentation such as unsupervised methods, Decision Forests and SVMs are described and pointers to the relevant papers are given. Recently published approaches with convolutional neural networks are mentioned and typical problematic situations for segmentation algorithms are examined. A taxonomy of segmentation algorithms is given.
African American Males Educational Success Factors

Due to the recent call for educators to increase African American educational achievement (Butler, 2012; Toldson, Sutton, & Brown, 2012; Harris & Taylor, 2012), the authors sought to identify personal characteristics associated with African American male educational success. There appears to be little discussion about this groupi¯s success in todayi¯s academic literature (Harper, 2009b). Thirty high-achieving African American male undergraduate students between the ages of 18 and 22 at an urban southeastern American university were surveyed. Participants completed Likert scale and open-response items regarding their success in college. The results suggest high achieving African-American males deem sources of inspiration, people, and financial incentives as important for educational success. Also, a significant difference was discovered between STEM (science, technology, engineering, or math) majors and non-STEM majors with regards to age, paternal relationship, and incentives (internal, external) to achieve goals. Implications for administrators and higher education were discussed.
A Thin-plate CAD Mesh Model Splitting Approach Based on Fitting Primitives

Extracting structural information from mesh models is crucial for Simulation Driven Design (SDD) in industrial applications. Focusing on thin-plate CAD mesh models (the most commonly used parts in electronic products such as PCs, mobile phones and so on), we present an algorithm based on primitive fitting for segmenting thin-plate CAD mesh models into parts of three different types, two of which are extruding surfaces and the other is a lateral surface. This method can be used for solid model reconstruction in the SDD process. Our approach involves two steps. First, a completely automatic method for accurate primitive fitting on CAD meshes is proposed based on the hierarchical primitive fitting framework. In the second step, a novel procedure is proposed for splitting thin-plate CAD mesh models by detecting parallel extruding surfaces and lateral surfaces. The method presented here has been proved to work smoothly in applications of real product design.
HR23b expression is a potential predictive biomarker for HDAC inhibitor treatment in mesenchymal tumours and is associated with response to vorinostat

Histone deacetylases (HDAC) are key players in epigenetic regulation of gene expression and HDAC inhibitor (HDACi) treatment seems to be a promising anticancer therapy in many human tumours, including soft tissue sarcomas. HR23b has been shown to be a potential biomarker for sensitivity to HDACi therapy in cutaneous T‐cell lymphoma and hepatocellular carcinoma. We aimed to evaluate HR23b as a candidate biomarker for HDACi response in sarcomas and gastrointestinal stromal tumours (GIST). Therefore, HR23b expression was analysed comprehensively by western blot in sarcoma and GIST cell lines covering all major clinically relevant subtypes. MTT assay and ApoTox‐GloTM Triplex assay were performed after treatment with vorinostat, belinostat, mocetinostat and entinostat. HR23b protein expression was measured under HDACi treatment. Furthermore, HR23b expression levels were immunohistochemically determined in a large set of 523 clinical samples from sarcoma and GIST patients. Western blot analyses showed that sarcomas differ significantly in their expression of HR23b protein. All HDACi were able to regulate proliferation and apoptosis in vitro. Sensitivity to vorinostat correlated significantly with HR23b protein expression. Immunohistochemical prevalence screening in clinical samples of relevant adult‐type tumours revealed that 12.5% of sarcomas (among them malignant peripheral nerve sheath tumours, pleomorphic liposarcomas, leiomyosarcomas, dedifferentiated liposarcomas, synovial sarcomas and angiosarcomas) and 23.2% of GIST show high HR23b expression. Therefore, HDACi have antiproliferative and proapoptotic effects in sarcomas depending on the expression level of HR23b. These findings suggest that HR23b represents a candidate biomarker for HDACi sensitivity in certain sarcoma types and in GIST.
SALZA: Soft algorithmic complexity estimates for clustering and causality inference

A complete set of practical estimators for the conditional, simple and joint algorihmic complexities is presented, from which a semi-metric is derived. Also, new directed information estimators are proposed that are applied to causality inference on Directed Acyclic Graphs. The performances of these estimators are investigated and shown to compare well with respect to the state-of-the-art Normalized Compression Distance (NCD).
DIFFUSE GLOMERULONEPHRITIS PRODUCED IN RABBITS BY MASSIVE INJECTIONS OF BOVINE SERUM GAMMA GLOBULIN

A high incidence of acute diffuse glomerulitis was produced in unilaterally nephrectomized rabbits by injection with two successive doses of purified bovine serum gamma globulin (fraction II). This experimental nephritis is morphologically analogous to human acute and subacute diffuse glomerulonephritis. The technique described is advanced as a valuable experimental method in the study of the pathogenesis of glomerulonephritis. Qualitative immunological investigations produced no evidence that the pathogenesis of experimental globulin nephritis is mediated by kidney autoantibodies. The rôle of hypersensitivity in the pathogenesis of nephritis is discussed. During the 1st week of the development of experimental globulin nephritis there is a significant increase in blood coagulability, as shown by a lowering of the mean coagulation time in globulin-treated animals during this period. This observation has not been reported previously. The possible relation of this increased blood coagulability to the formation of coagula in the glomerular capillaries is discussed. The injection of a single purified antigen (bovine serum gamma globulin) produced three distinct types of lesion, diffuse glomerulitis, focal granulomata of the heart valves and valve rings, and coronary arteritis.
Associations between breaks in sedentary time and body size in Pacific mothers and their children: findings from the Pacific Islands Families study.

BACKGROUND Breaks in sedentary behavior are associated with reduced body size in general populations. This study is the first to consider the relationship between objectively assessed sedentary breaks and body size in Pacific children and their mothers. METHODS Pacific children aged 6 years (n = 393) and their mothers (n = 386) residing in New Zealand were invited to participate in 2006. Sedentary time was assessed via accelerometry. Average frequency, duration, and intensity of breaks in sedentary time per hour were calculated. Waist circumference was assessed and demographic factors collected via questionnaire. Relationships between waist circumference and potential associated factors for participants were assessed using linear regression analyses. RESULTS Accelerometer data were obtained from 126 children (52 boys) and 108 mothers. Mean (standard deviation) waist circumference values for mothers and children were 114 cm (20.1 cm) and 59.4 cm (7.8 cm), respectively. For mothers, time spent sedentary and being an ex/nonsmoker were positively related to waist circumference. For children, watching television every day and having a mother with a high waist circumference was associated with a greater waist circumference. CONCLUSION Strategies that focus on reducing sedentary time in Pacific mothers and on encouraging television free days in young Pacific children are recommended.
Utility-maximization framework for dynamic adaptive streaming over HTTP in multi-user MIMO LTE networks

Recent years have witnessed the emergence and ongoing proliferation of dynamic adaptive streaming over HTTP (DASH1), which reuses web servers with HTTP communication instead of relying on RTP-based media server and promises to be capable of automatically tuning to bandwidth dynamics. The third generation partnership project (3GPP) long term evolution (LTE) has adopted DASH for use in order to realize ubiquitous multimedia delivery. In a multi-user multiple-input-multiple-output (MU-MIMO) LTE system, spatial multiplexing gain can be achieved by making the transmitter deliver distinct data streams to multiple receivers simultaneously, which provides choices to schedule preferred receivers for a common resource. In such a system, one of the major challenges to enhance adaptive HTTP streaming performance is to design an effective scheduler that can fully enjoy the benefit of spatial reuse as well as guaranteeing satisfactory video services for all users. To this end, we propose a utility maximization framework (UMF) for DASH application over MU-MIMO LTE downlinks. In particular, we characterize DASH performance by a combined utility function in terms of average video rate, playback buffer status, and battery energy state. Correspondingly, we develop a utility-based scheduler that selects multiple user equipments (UEs) to share each common network resource under the consideration of precoding-based MU-MIMO in order to maximize system-wide DASH performance. Specifically, we propose a priority search algorithm to provide time-efficient solution to the scheduling problem. We further incorporate novel rate adaptation on the application layer for scheduled UEs to dynamically set the requested video encoding bitrates. Extensive system-level simulations validate the effectiveness of UMF in terms of rate adaptability, playback buffer depletion percentage and battery energy consumption.
Conflict Detection Scheme Based on Formal Rule Model for Smart Building Systems

Smart building systems can provide flexible and configurational sensing and controlling operations according to users' requirements. As the number and the complexity of service rules customized by users have significantly increased, there is an increasing danger of conflict during the interaction process between users and the system. To address this issue, we propose a new rule conflict detection scheme tailored for the smart building system. First, we present a formal rule model UTEA based on User, Triggers, Environment entities, and Actuators. This model can handle not only controlled devices with discrete status but also real-valued environmental data such as temperature and humidity. In addition, this model takes multiple users with different authorities into account. Second, we define 11 rule relations and further classify conflicts into five categories. Third, we implement a rule storage system for detecting conflicts and design a conflict detection algorithm, which can detect the conflict between two rules as well as cycle conflict/multicross contradiction among multiple rules. We evaluated our scheme in a real smart building system with more than 30 000 service rules. The experiment results show that our scheme improves the performance in terms of error/missed-detection rates and running time.
Minimisation of video downstream bit rate for large scale immersive video conferencing by utilising the perceptual variations of quality

This paper aims at minimising the video downstream bit rate of immersive video conferencing (IVC) applications by judiciously modifying the video quality based on the relative virtual positions of participants in the virtual environment. The paper reports on the results of a user study to assess the influence of participants' perspectives on the perceptual impact of relevant video parameters, such as resolution and frame rate. A mathematical model for video rate is proposed that expresses the total rate as the product of spatial resolution and frame rate. Results from the user study are combined with the proposed model to predict the rate parameters which will result in perceptually acceptable quality for a given user perspective. The simulation results show that by exploiting the proposed method, the downstream network load for the client can be significantly reduced with little or no impact on the perceived quality.
METHODS Virus Preparation and Inoculation of Mice The M variant of EMCV ( American Type Culture

Ju-Feng Wang,* Achim Meissner,* Sohail Malek, Yu Chen, Qingen Ke, Jielin Zhang, Victor Chu, Thomas G. Hampton, Clyde S. Crumpacker, Walter H. Abelmann, Ivo Amende, and James P. Morgan Cardiovascular Division, Department of Medicine, and Harvard Thorndike Research Institute, and Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; and Cardiovascular Division, Department of Internal Medicine and Cardiology, Stadtkrankenhaus Soest, Soest, Germany
A kinematic, kinetic and electromyographic analysis of 1-repetition maximum deadlifts

A kinematic, kinetic and electromyographic analysis of 1-repetition maximum deadlifts Author (s): Jonathan Carbe, Arvid Lind Institute: Department of Food and Nutrition, and Sport Science University of Goteborg P.O Box 300 S-405 30 Goteborg SWEDEN Essay: 15 ECTS Programme/ course: Sports Coaching Level: Basic Semester/year: Vt 2014 Tutor: Jesper Augustsson Nr. in serie: 50 Date: 2014-06-09 Number of pages: 18 Summary : To date, no study has explored the deadlift in terms of studying both individual body joint angles and muscle recruitment strategy on well-trained powerlifters lifting at 1repetition maximum (1RM). The primary purpose of this study was to describe these two technical parameters and the relationship between them during 1RM deadlifts. The secondary purpose was to investigate the correlations between the relative strength parameter (1RM/BW) and lifting angle and muscle activation parameters. Ten male powerlifters with >1 year of training experience with the deadlift volunteered to participate in the study. Their mean (±SD) age, body mass, height, 1RM and 1RM normalized for body mass were 25±3 years, 86±4 kg, 183±7 cm, 220±26 kg and 2,6±0,2 1RM/body mass, respectively. The subjects were equipped with six EMG transmitters and 25 reflective markers and performed 1RM deadlifts, with each lift recorded by 16 motion analysis cameras. Main findings were considered as 1) hunching of the lower back occurred probably as a result of insufficient erector spinae (ES) activation, 2) a mean supramaximal (>100% of maximal voluntary isometric contraction (MVIC)) activation of the biceps femoris (BF) and the gluteus maximus (GM) at knee passage (KP), 3) a ”shift” in dominating knee muscle activity from the vastus medialis at lift-off (LO), to BF at KP. Furthermore, Pearson’s r correlation analyses revealed significant (p 1 ars traningserfarenhet av marklyftstraning deltog. Deras genomsnittliga (±SA) alder, kroppsvikt (BW), langd, 1RM och 1RM/BW var 25±3 ar, 86±4 kg, 183±7 cm, 220±26 kg och 2,6±0,2 1RM/BW. Forsokspersonerna utrustades med sex stycken EMG-transmittorer samt 25 stycken reflexmarkorer och utforde marklyft pa en intensitet motsvarande 1RM, dar varje lyft spelades in av 16 stycken rorelseanalyskameror. De huvudsakliga fynden i studien lod enligt foljande: 1) krummande av landryggen uppkom sannolikt som ett resultat av bristfallig aktivitet i erector spinae (ES), 2) en genomsnittlig supramaximal (>100% av maximal isometrisk kontraktion (MVIC)) aktivering av biceps femoris (BF) samt gluteus maximus (GM) vid knapassage (KP), 3) en "vaxling" i dominerande knamuskelaktivitet fran vastus medialis (VM) vid draglage (LO), till BF vid KP. Vidare visade Pearsons rkorrelationsanalyser signifikanta (p < .05) och starka korrelationsvarden mellan 1RM/BW och 1) BW(-r=.75), 2) GM-aktivitet vid LO (r=.63) och 3) hoftvinkel (HA) vid LO (r=.64). Dessa fynd kan betraktas som betydelsefulla fran ett prestationsperspektiv saval som fran ett skadeprofylaktiskt sadant.