Miracle-dz/UniFAR-FTUs huggingface dataset:
Cellular Immunotherapy: Using Alloreactivity to Induce Anti-Leukemic Responses without Prolonged Persistence of Donor Cells

A goal of cancer immunologists is to harness cellular immune responses to achieve anti-cancer responses. One of the strongest activating stimuli for the immune system is the encounter with cells expressing allogeneic HLA molecules. While alloreactive responses can negatively impact of the outcome of hematopoietic stem cell transplant because of graft-versus-host disease (GVHD), these same responses can have anti-leukemic effects. Donor lymphocyte infusions have been used in an attempt to harness alloreactive responses to achieve anti-leukemic responses. Because this protocol is usually carried out in the absence of recipient anti-donor responses, this protocol often induces GVHD as well as anti-leukemic responses. A recent study indicated the infusion of large number of haploidentical donor cells (1–2 × 108 CD3+ cells/kg) into patients with refractory hematological malignancies (100 cGy total body irradiation) resulted in 14 (7 major) responses/26 patients. A rapidly developing cytokine storm was observed, while no persisting donor cells could be detected at two weeks after infusion eliminating the possibility of GVHD. Characterization of the effector mechanisms responsible for the anti-leukemic responses in this protocol, should guide new approaches for achieving enhanced anti-leukemic responses using this protocol.
Mechanics and erosion of basement-cored uplift provinces

[1] Basement-cored uplift provinces are often characterized by high-angle reverse faulting along preexisting crustal heterogeneities, which may greatly affect the mechanics of deformation and the coupling between erosion and orogenic structure. Herein we construct a coupled deformation-erosion model to understand the mechanics and erosion of mountain belts in which the spatial distribution of deformation is largely influenced by the presence of preexisting high-angle faults. In this case, deformation is accommodated along, and topography is built above, these structures. This topographic loading leads to increasing lithostatic stresses beneath these regions. As a result, active deformation may migrate to frictionally stronger structures in adjacent regions where lithostatic loading is lower. The migration of deformation to such nearby structures depends on the Hubbert-Rubey pore fluid pressure ratio of the crust (λ), the orientations of the frictionally weaker and stronger preexisting faults (β1 and β2, respectively), the friction coefficients (μb1 and μb2) and Hubbert-Rubey fluid-pressure ratios (λb1 and λb2) of these faults, and the surface slope of the topography above the frictionally weaker structure (α), assuming zero surface slope above the frictionally stronger structure. In general, we found that for a given α and β1, as μb1 increases λ = λb1 = λb2 increases, and β2 decreases, the value of μb2 required to force deformation to migrate increases. However, as erosional processes lead to decreasing surface slopes, deformation will be inhibited from migrating to frictionally stronger structures in adjacent regions. Our model results may help to explain some aspects of the deformation observed and the possible correlation between precipitation and the migration of deformation within these tectonic provinces.
Optimal Linear Separation of the Safe and Unsafe Subspaces of Sequential Resource Allocation Systems as a Set-Covering Problem: Algorithmic Procedures and Geometric Insights

A recent line of work has posed the design of the maximally permissive deadlock avoidance policy for a particular class of sequential resource allocation systems as a linear classification problem. It has also identified a connection between the classifier design problem addressed by it and the classical set-covering problem that has been studied in operations research and computer science. This paper seeks to explore and formalize further this connection, in an effort to (i) develop novel insights regarding the geometric and combinatorial structure of the classifier design problem mentioned above; (ii) set an analytical base for the development of additional customized and computationally (more) efficient algorithms for its solution; and (iii) identify necessary and sufficient conditions, and the corresponding computational tests, for the effective application and the extension of the representational results in the aforementioned work to broader classes of resource allocation systems.
Anisotropic inverse conductivity and scattering problems

Uniqueness in inverse conductivity and scattering problems is considered. In the case when the medium consists of two discontinuous constant anisotropic conductive parts, the measurements of potential and induced currents on the boundary of the surrounding body are enough to guarantee uniqueness to determine conductivity and a region of embedded unknown material under a very weak condition. The analogous uniqueness result is also obtained for an inverse scattering problem in the case that the medium is composed of two anisotropic and homogeneous materials.
The histochemical localization of cytochrome oxidase in the retina and lateral geniculate nucleus of the ferret, cat, and monkey, with particular reference to retinal mosaics and ON/OFF-center visual channels

The histochemical localization of cytochrome oxidase within the normal retina and lateral geniculate nucleus (LGN) of cats, ferrets, and monkeys revealed that distinct layers, types of cells, and portions of neurons are more intensely stained than others. The dark staining of photoreceptor inner segments and cone pedicles and the light staining of photoreceptor outer segments, somata, and rod spherules demonstrates that different segments of the same cell may have disparate but distinct levels of oxidative enzyme activity. In tangential sections of retina, regular mosaic arrays were evident for each of several darkly reactive retinal components, such as cone inner segments, cone pedicles, and horizontal cells. In the cat and ferret, regular mosaic arrays were also formed by metabolically distinguishable populations of ganglion cells. Ia and IIa ganglion cells (OFF-; Nelson, R., E. V. Famiglietti, Jr., and H. Kolb (1978) J. Neurophysiol. 41: 472–483) were more darkly reactive than the other classes. The darker staining of sublamina a of the inner plexiform layer (OFF-; Famiglietti, E. V., Jr., and H. Kolb (1976) Science 194: 193–195) in the cat and ferret retina, as well as sublamina A′ and A1′ of the ferret LGN (OFF-; Stryker, M.P., and K.R. Zahs (1983a) J. Neurosci. 3: 1943–1951) suggest that, under typical rearing conditions, the OFF-channels may be metabolically more active than the ON-channels in these species. In Macaca and Saimiri, darker staining was observed in sublamina b of the inner plexiform layer (ON-; Famiglietti, E.V., Jr., and H. Kolb (1976) Science 194: 193–195) and laminae 1, 2, and 6 of the LGN, implying that, under similar rearing conditions, a different pattern is observed. The dark staining of many large retinal ganglion cells, as well as most of the larger LGN neurons (presumed Y/Y-like), in all species studied is evidence that the Y/Y-like pathway is also highly active.
Knowledge Acquisition for Knowledge Management

Knowledge is considered to be “the information needed to make business decisions”, and so knowledge management is the “essential ingredient of success” for 95 per cent of CEOs [Manchester 1999]. A company’s value depends increasingly on “intangible assets” which exist in the minds of employees, in databases, in files and in a myriad documents. Knowledge management technologies capture this intangible element in an organisation; and make it universally available. The most widely used method of mapping the knowledge of a domain is to use an ontology describing such a domain. Ontologies can act as an index to the memory of an organisation and facilitate semantic searches and the retrieval of knowledge from the corporate memory as it is embodied in documents and other archives. There are many real-world examples where the utility of ontologies as maps or models of specific domains has been repeatedly proven.
Exploiting edge capability for wireless sensor networking

As considerable progress is being made in wireless sensor networking, it is envisioned that sensor nodes will be on the cubic millimeter scale, posing stringent constraints on the processing, communication, and storage capabilities of sensor nodes. While it is important to continue pursuing novel algorithms and protocols to squeeze the most out of the existing design space (sensor nodes), it is equally important to explore a new design paradigm for future sensor networks to reduce the complexity burden on sensor nodes. We propose to exploit capabilities at the network edge (i.e., an edge-based approach). We overview existing approaches to this end and present a novel edge-based routing protocol, called BeamStar, as a case study. We show that exploiting edge capability provides a new dimension of freedom for wireless sensor networking, and is effective in relieving the processing, communication, and storage requirements of sensor nodes.
Question Answering Experiments at NTCIR-5: Acquisition of Answer Evaluation Patterns and Context Processing using Passage Retrieval

In our participation in QAC3, our Question Answering system developed for QAC2 is extended in two ways, separately. The first system is constructed to improve the performance of answer evaluation. The automatic lexico-syntactic pattern acquisition from large corpora and the method to incorporate the patterns into QA system are developed and evaluated. The second system is constructed to implement the ability of context processing for information access dialogue (IAD), which is a main target ofQAC3 evaluation. The system exploits passage retrieval for selecting an appropriate context from the history of the series questions, in order to compose a complete question.
Back to the subseismic approximation for core undertones

The problem of the long-period gravity modes of the Earth outer fluid core is investigated using either the subseismic or the anelastic approximation These two approximations aim at filtering out the uninteresting short-period seismic or acoustic oscillations while taking into account the density variations across the core However, they differ on the form of the equation of mass conservation since the density perturbations do not contribute to the mass balance in the anelastic case Here we show that these two approximations lead to the almost same results because of the weakness of the core stratification due to the convective mixing The anelastic approximation should be however preferred because it is simpler, mathematically self-consistent and is the only one which can be applied to problems with a stronger stratification such as the ones encountered in radiative zones of stars
A SiGe V-band x8 frequency multiplier with high spectral purity

A compact frequency octupler designed for upper and lower E-band transceivers is implemented in IBM 0. 13μm SiGe technology. Three frequency doubler stages are used with harmonic rejection conducted at the first two doublers for wide band spectral purity. With a 0 dBm input power, the frequency octupler reaches above 7.5 dBm output power between 56 GHz to 84 GHz with a peak output power of 13.5 dBm. All even harmonics: 2nd, 4th, 6th, 10th, are suppressed by more than 40 dBc across the frequency band. Moreover, the 6th and 10th harmonics are suppressed by over 40 dBc at temperatures between -40°C to 85°C. The circuit enables an extra input option of a frequency quadrupler and occupies 1.23×1.1 mm2 and consumes 152 mA from a 2.7 V supply.
RE-SPaM: Using Regular Expressions for Sequential Pattern Mining in Trajectory Databases

In sequential pattern mining, languages based on regular expressions (RE) were proposed to restrict frequent sequences to the ones that satisfy user-specified constraints. In these languages, REs are applied over items. We propose a much powerful language, based on regular expressions, denoted RE-SPaM, where the basic elements are constraints over the attributes of the items. Expressions in this language may include attributes, functions over attributes, and variables. We present the data model, sketch the syntax and semantics of RE-SPaM, a set of examples, and suggest how it can be used in the mining process.
The use of doubly fed reluctance machines for large pumps and wind turbines

Brushless doubly-fed induction machines (BDFIMs) have been extensively researched over the last 15 years because of the possibility of using a partially rated inverter in many applications with limited speed variations. However, the special cage rotor construction and substantial rotor losses is one of the key deficiencies of these machines. A similar and extremely interesting machine, the brushless doubly-fed reluctance machine (BDFRM), has been largely ignored in comparison. This was mainly due to the fact that reluctance rotor designs were not capable of generating saliency ratios large enough to make the BDFRM competitive with other machines. However recent developments in reluctance rotors, spurred on by research into synchronous reluctance machines, have resulted in high saliency ratio cageless rotors that are economic to build. This, together with the promise of higher efficiency and simpler control compared to the BDFIM, means that further investigation of the BDFRM is warranted. This paper presents a comparative theoretical analysis of the important control properties and related machine performance/inverter size trade-offs for the BDFRM in the light of its most likely applications-large pump type adjustable speed drives and variable speed constant frequency wind power generation systems.
A full integration of electromagnetic resonance sensor and capacitive touch sensor into LCD

We have developed a transmissive and reflective LCD that integrates electromagnetic resonance (EMR) and capacitive touch sensors using existing in‐cell process. This development has been achieved by utilizing our hybrid‐in‐cell technology with low resistance material for the RX, which is an improvement of over 80% compared with conventional indium thin oxide (ITO) material. For EMR detection, we have slightly modified the TX layer used for capacitive touch sensing, by making a coil loop that generates a magnetic field on the panel. The direction of current on the coil can be modulated by the low‐temperature polycrystalline silicon (LTPS) circuit. Our in‐cell touch sensing has separately assigned timings for display and touch units. This time‐sharing method provides immunity from display noise and consequently better signal‐to‐noise ratio (SNR) than other out‐cell types. In parallel, we have developed a new controller that can support both EMR and capacitive sensing as a one‐chip solution, with the capability of maximizing signal levels lowering noise and detecting the frequency precisely when there is pressure on the pen tip. Our in‐cell technologies contribute not only a good SNR for EMR pen but also the added benefits for thin design, lightweight panel, compared with conventional LCD techniques.
Reparative therapy of male homosexuality: A new clinical approach.

Will reading habit influence your life? Many say yes. Reading reparative therapy of male homosexuality a new clinical approach is a good habit; you can develop this habit to be such interesting way. Yeah, reading habit will not only make you have any favourite activity. It will be one of guidance of your life. When reading has become a habit, you will not make it as disturbing activities or as boring activity. You can gain many benefits and importances of reading.
Multibase: integrating heterogeneous distributed database systems

Multibase is a software system for integrating access to preexisting, heterogeneous, distributed databases. The system suppresses differences of DBMS, language, and data models among the databases and provides users with a unified global schema and a single high-level query language. Autonomy for updating is retained with the local databases. The architecture of Multibase does not require any changes to local databases or DBMSs. There are three principal research goals of the project. The first goal is to develop appropriate language constructs for accessing and integrating heterogeneous databases. The second goal is to discover effective global and local optimization techniques. The final goal is to design methods for handling incompatible data representations and inconsistent data. Currently the project is in the first year of a planned three year effort. This paper describes the basic architecture of Multibase and identifies some of the avenues to be taken in subsequent research.
DISTRIBUTION, INHERITANCE, AND PROPERTIES OF AN ANTIGEN, MUB1, AND ITS RELATION TO HEMOLYTIC COMPLEMENT

An antigen, MuB1, present in the sera of some mice, can elicit a precipitating antibody in certain other strains of mice. An antibody to the antigen MuB1 can also be elicited in rabbits. 99 strains and substrains of inbred mice were tested for the presence of MuB1; the antigen was found in the sera of 44 strains (61 per cent) and 14 DBA substrains (52 per cent). Evidence is presented indicating that mice lacking MuB1 do not make a modified antigen, corresponding to MuB1, but are genetically deficient in synthetic ability at this site. By reaction with antibody to MuB1 an antigen corresponding to MuB1 was found in 13 of the 15 orders of mammals, and in 63 of 85 mammalian species tested, including man and guinea pig. The quantity of the antigen MuB1 is always greater in the serum of male than in the serum of female mice. The concentration of MuB1 increases with age; this increase is more marked in male than in female mice. By means of backcross experiments it was shown that the inheritance of MuB1 is unifactorial, is independent of the inheritance of the gamma globulin allotype MuA2, and is qualitatively independent of the sex of the parents. The antigen MuB1 is found in the euglobulin fraction of serum; it loses its ability to precipitate with antibody after heating at 56°C, but not after treatment with ammonia or hydrazine. By gel filtration, MuB1 is separated with a fraction containing molecules of molecular weight ≈ 150,000. An empirical correlation was observed between the presence or absence of MuB1 in the sera from inbred mice and the presence or absence of hemolytic complement (Hc), as measured by a test using a high concentration of rabbit hemolysin. In backcross experiments also, a correlation between hemolytic complement and the presence of MuB1 was demonstrated. As with MuB1, male mice had a higher hemolytic complement level than females. The particular component of complement which may be identical with MuB1 has not been identified.
A NUMBER OF APPROACHES TO SUBSPACE CLUSTERING HAVE BEEN PROPOSED IN THE PAST TWODECADES

[ Applications in motion segmentation and face clustering] T he past few years have witnessed an explosion in the availability of data from multiple sources and modalities. For example, millions of cameras have been installed in buildings, streets, airports, and cities around the world. This has generated extraordinary advances on how to acquire, compress, store, transmit, and process massive amounts of complex high-dimensional data. Many of these advances have relied on the observation that, even though these data sets are high dimensional, their intrinsic dimension is often much smaller than the dimension of the ambient space. In computer vision, for example, the number of pixels in an image can be rather large, yet most computer vision models use only a few parameters to describe the appearance, geometry, and dynamics of a scene. This has motivated the development of a number of techniques for finding a low-dimensional representation of a high-dimensional data set. Conventional techniques, such as principal component analysis (PCA), assume that the data are drawn from a single low-dimensional subspace of a high-dimensional space. Such approaches have found widespread applications in many fields, e.g., pattern recognition, data compression, image processing, and bioinformatics. In practice, however, the data points could be drawn from multiple subspaces, and the membership of the data points to the subspaces might be unknown. For instance, a video sequence could contain several moving objects, and different subspaces might be needed to describe the motion of different objects in the scene. Therefore, there is a need to simultaneously cluster the data into multiple subspaces and find a low-dimensional subspace fitting each group of points.
A History of Warfare.

He examines every branch of warfare in its history, psychology, metallurgy, genetics, logistics, archaeology, tactics and strategy.He is as much at home in the Empire of Babylon as he is on the Somme.On every subject he has something fresh to say. His learning is staggering and his gift for exposition unequalled' Nigel Nicolson, Daily Telegraph. 'Keegan's power as a writer derives from the fact that he does not see himself merely as a chronicler of battles, but as a student of the human condition. It is the breadth of his grasp of civilisation, as well as of the soldier's art, that makes this book so formidable. ' Max Hastings, Evening Standard. 'A masterpiece.One of those rare books which could still be required reading in its field a hundred years from now' New Yorker. 'Our finest military historian has produced a book of breathtaking scope.A tour de force' Niall Ferguson, Daily Mail. 'The best book I read in 1993 was A History of Warfare.A dazzling display of historical pyrotechnics' Paul Johnson, Books of the Year, Sunday Times. 'Magnificent' Sunday Telegraph.
Parallel Complexity of the Lexicographically First Maximal Subgraph Problems on Restricted Graphs

Longest directed path length (LDPL) is de ned by the length of the longest path of the directed acyclic graph of a given undirected graph. The LDPL of a graph measures the parallelization for the lexicographically rst maximal subgraph (LFMS) problems. That is, the parallel complexity of the problems gradually increases as the value measured on a graph grows; the LFMS problems are in NC on graphs of LDPL O(log k n), and P-complete on graphs of LDPL cn . It is worth remarking that the problem to compute the LDPL is in NC 2 . The LDPL on a random graph is also considered, and the threshold value for the LDPL l is l n for a random graph G(n; p).
Humanoid's dual arm object manipulation based on virtual dynamics model

In order to implement promising robot applications in our daily lives, robots need to perform manipulation tasks within the human environments. Especially for a humanoid robot, it is essential to manipulate a variety of objects with different shapes and sizes to assist humans in the human environments. This paper presents a method of manipulating objects with humanoid robot's dual arms. The robot is usually asked to control both the motion and force to manipulate the objects. We propose a novel concept of control method based on the virtual dynamics model (VDM), which enables the robot to perform both tasks of reaching to an object and grasping it under the uniform control system. Furthermore, the impedance model based on the VDM controller also enables the robot to safely grasp an object by reducing the impact at the contact point. The proposed algorithm is implemented on the humanoid robot, Mahru, with independent joint controller at each motor. Its performance is demonstrated by manipulating different types of objects.