Miracle-dz/UniFAR-FTUs huggingface dataset:
Materials and Process Optimization for Performance Enhancement and Cost Reduction for the Packaging of LED Emitters and Solar Cells

Author(s): Shih, Yu-Chou | Advisor(s): Shi, Frank G. | Abstract: Solar cells and light-emitting diodes (LEDs) are the two most beneficial optoelectronic devices to humanity with opposite functions: one converts photons into electrical power and the other one converts electrons into luminance. Remarkable advances in both applications have been made in both novel chip-level design and packaging technologies, and the continuous innovation and improvement of packaging materials and methods have played key roles in the past two decades. In this work, new packaging materials and technologies are introduced to both silicon solar cells and LEDs to enhance their performance. The first part of this work was to develop a new silver paste with different glass frits for front-side metallization in silicon solar cells. It is shown that the replacement of micro-sized glass frits by nano-sized ones can dramatically reduce the specific contact resistivity between the resultant silver electrodes and the n-type silicon layer due to the excellent etching ability of nanopartilces on removing the anti-reflection coating (ARC). Surface modification on nano-sized glass frits by electroless plating can further improve the electrical performance by offering extra conducting channel within the insulating layers. In the second part of this work, the influence of different die attach adhesives (DAAs) on optical and thermal performance of LED emitters was studied. The results show that with an optically clear DAA applied, the highest optical output can be achieved due to its high transparency. The optically reflective DAA also exhibit excellent optical performance, especially at low fillet coverage, which block the photons escaping from the side walls. For high power LED applications, the optically reflective DAA can achieve better thermal management than the conventional one when the bondline thickness is controlled at 7.6 micron. The last part of this work focuses on the interaction between the LED emitters and the backside reflector, which is used to reflect the downward photons. Our results show that with both optically clear and reflective DAAs, the light output of LED emitters can be very close to that of LED emitters with backside reflectors.
Effect of Lower and Upper Body High Intensity Training on Genes Associated with Cellular Stress Response

This study aimed to compare the effect of upper and lower body high intensity exercise (HIE) on select gene expression in athletes. Fourteen elite male artistic gymnasts (age 20.9 ± 2.6 years; weight 68.6 ± 7.2 kg; fat free mass 63.6 ± 6.7 kg; height 1.70 ± 0.04 m) performed lower and upper body 30 s Wingate Tests (WAnTs) before and after eight weeks of specific HIIT. Two milliliters of blood was collected before and after (5, 30 min, resp.) lower and upper body WAnTs, and select gene expression was determined by PCR. Eight weeks of HIIT caused a significant increase in maximal power (722 to 751 Wat), relative peak power in the lower body WAnTs (10.1 to 11 W/kg), mean power (444 to 464 W), and relative mean power (6.5 to 6.8 W/kg). No significant differences in lower versus upper body gene expression were detected after HIIT, and a significant decrease in the IL6/IL10 ratio was observed after lower (−2∧0.57 p = 0.0019) and upper (−2∧0.5 p = 0.03) WAnTs following eight weeks of HIIT. It is hypothesized that a similar adaptive response to exercise may be obtained by lower and upper body exercise.
Pulse wave imaging using coherent compounding in a phantom and in vivo

Pulse wave velocity (PWV) is a surrogate marker of arterial stiffness linked to cardiovascular morbidity. Pulse wave imaging (PWI) is a technique developed by our group for imaging the pulse wave propagation in vivo. PWI requires high temporal and spatial resolution, which conventional ultrasonic imaging is unable to simultaneously provide. Coherent compounding is known to address this tradeoff and provides full aperture images at high frame rates. This study aims to implement PWI using coherent compounding within a GPU-accelerated framework. The results of the implemented method were validated using a silicone phantom against static mechanical testing. Reproducibility of the measured PWVs was assessed in the right common carotid of six healthy subjects (n = 6) approximately 10–15 mm before the bifurcation during two cardiac cycles over the course of 1–3 d. Good agreement of the measured PWVs (3.97 ± 1.21 m s−1, 4.08 ± 1.15 m s−1, p = 0.74) was obtained. The effects of frame rate, transmission angle and number of compounded plane waves on PWI performance were investigated in the six healthy volunteers. Performance metrics such as the reproducibility of the PWVs, the coefficient of determination (r2), the SNR of the PWI axial wall velocities (SNRvPWI) and the percentage of lateral positions where the pulse wave appears to arrive at the same time-point, indicating inadequacy of the temporal resolution (i.e. temporal resolution misses) were used to evaluate the effect of each parameter. Compounding plane waves transmitted at 1° increments with a linear array yielded optimal performance, generating significantly higher r2 and SNRvPWI values (p ⩽ 0.05). Higher frame rates (⩾1667 Hz) produced improvements with significant gains in the r2 coefficient (p ⩽ 0.05) and significant increase in both r2 and SNRvPWI from single plane wave imaging to 3-plane wave compounding (p ⩽ 0.05). Optimal performance was established at 2778 Hz with 3 plane waves and at 1667 Hz with 5 plane waves.
Dimension-Based Statistical Learning Affects Both Speech Perception and Production.

Multiple acoustic dimensions signal speech categories. However, dimensions vary in their informativeness; some are more diagnostic of category membership than others. Speech categorization reflects these dimensional regularities such that diagnostic dimensions carry more "perceptual weight" and more effectively signal category membership to native listeners. Yet perceptual weights are malleable. When short-term experience deviates from long-term language norms, such as in a foreign accent, the perceptual weight of acoustic dimensions in signaling speech category membership rapidly adjusts. The present study investigated whether rapid adjustments in listeners' perceptual weights in response to speech that deviates from the norms also affects listeners' own speech productions. In a word recognition task, the correlation between two acoustic dimensions signaling consonant categories, fundamental frequency (F0) and voice onset time (VOT), matched the correlation typical of English, and then shifted to an "artificial accent" that reversed the relationship, and then shifted back. Brief, incidental exposure to the artificial accent caused participants to down-weight perceptual reliance on F0, consistent with previous research. Throughout the task, participants were intermittently prompted with pictures to produce these same words. In the block in which listeners heard the artificial accent with a reversed F0 × VOT correlation, F0 was a less robust cue to voicing in listeners' own speech productions. The statistical regularities of short-term speech input affect both speech perception and production, as evidenced via shifts in how acoustic dimensions are weighted.
Pneumococcal Community-Acquired Pneumonia Detected by Serotype-Specific Urinary Antigen Detection Assays

Background Streptococcus pneumoniae is considered the leading bacterial cause of pneumonia in adults. Yet, it was not commonly detected by traditional culture-based and conventional urinary testing in a recent multicenter etiology study of adults hospitalized with community-acquired pneumonia (CAP). We used novel serotype-specific urinary antigen detection (SSUAD) assays to determine whether pneumococcal cases were missed by traditional testing. Methods We studied adult patients hospitalized with CAP at 5 hospitals in Chicago and Nashville (2010-2012) and enrolled in the Etiology of Pneumonia in the Community (EPIC) study. Traditional diagnostic testing included blood and sputum cultures and conventional urine antigen detection (ie, BinaxNOW). We applied SSUAD assays that target serotypes included in the 13-valent pneumococcal conjugate vaccine (PCV13) to stored residual urine specimens. Results Among 1736 patients with SSUAD and ≥1 traditional pneumococcal test performed, we identified 169 (9.7%) cases of pneumococcal CAP. Traditional tests identified 93 (5.4%) and SSUAD identified 76 (4.4%) additional cases. Among 14 PCV13-serotype cases identified by culture, SSUAD correctly identified the same serotype in all of them. Cases identified by SSUAD vs traditional tests were similar in most demographic and clinical characteristics, although disease severity and procalcitonin concentration were highest among those with positive blood cultures. The proportion of PCV13 serotype cases identified was not significantly different between the first and second July-June study periods (6.4% vs 4.0%). Conclusions Although restricted to the detection of only 13 serotypes, SSUAD testing substantially increased the detection of pneumococcal pneumonia among adults hospitalized with CAP.
On Algebraic Proofs of Stability for Homogeneous Vector Fields

We prove that if a homogeneous, continuously differentiable vector field is asymptotically stable, then it admits a Lyapunov function, which is the ratio of two polynomials (i.e., a rational function). We further show that when the vector field is polynomial, the Lyapunov inequalities on both the rational function and its derivative have sum of squares certificates and, hence, such a Lyapunov function can always be found by semidefinite programming. This generalizes the classical fact that an asymptotically stable linear system admits a quadratic Lyapunov function, which satisfies a certain linear matrix inequality. In addition to homogeneous vector fields, the result can be useful for showing local asymptotic stability of nonhomogeneous systems by proving asymptotic stability of their lowest order homogeneous component. This paper also includes some negative results: We show that in absence of homogeneity, globally asymptotically stable polynomial vector fields may fail to admit a global rational Lyapunov function, and in presence of homogeneity, the degree of the numerator of a rational Lyapunov function may need to be arbitrarily high (even for vector fields of fixed degree and dimension). On the other hand, we also give a family of homogeneous polynomial vector fields that admit a low-degree rational Lyapunov function but necessitate polynomial Lyapunov functions of arbitrarily high degree. This shows the potential benefits of working with rational Lyapunov functions, particularly as the ones whose existence we guarantee have structured denominators and are not more expensive to search for than polynomial ones.
Therapeutic Effectiveness and Safety of Mesotherapy in Patients with Osteoarthritis of the Knee

Objective To evaluate the therapeutic effectiveness and safety of mesotherapy by comparing it with the classic systematic therapy in patients with osteoarthritis (OA). Methods Sixty patients were included and classified into two groups based on the existence of contraindications for nonsteroidal anti-inflammatory drugs (NSAIDs). These patients were treated with oral NSAIDs (Group A) or mesotherapy (Group B). After completing the treatment, the patients were followed up for 6 months. Their clinical features, laboratory results, and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores were evaluated. Results A total of 50 patients completed treatment and follow-up. The patients in Group B had significantly fewer gastric acid-related complaints and requested less supplementary treatment for recurrent pain (p < 0.05). The patients in both groups exhibited decreased blood viscosity after treatment (p < 0.05). WOMAC scores, specifically those for pain and stiffness, were found to be significantly improved after either type of treatment (p < 0.05). Mesotherapy also ameliorated physical function (p < 0.05). Furthermore, Group B presented with better outcomes than Group A (p < 0.05 or p < 0.01). Conclusion Our results suggest that mesotherapy is an effective and safe treatment for patients with OA. Clinicians should consider mesotherapy as an alternative therapy for patients with contraindications for NSAID use.
Lack of ACTPK1, an STY kinase, enhances ammonium uptake and use, and promotes growth of rice seedlings under sufficient external ammonium

Ammonium influx into plant roots via the high-affinity transport system (HATS) is down-modulated under elevated external ammonium, preventing ammonium toxicity. In ammonium-fed Arabidopsis, ammonium transporter 1 (AMT1) trimers responsible for HATS activity are allosterically inactivated in a dose-dependent manner via phosphorylation of the conserved threonine at the carboxyl-tail by the calcineurin B-like protein 1-calcineurin B-like protein-interacting protein kinase 23 complex and other yet unidentified protein kinases. Using transcriptome and reverse genetics in ammonium-preferring rice, we revealed the role of the serine/threonine/tyrosine protein kinase gene OsACTPK1 in down-modulation of HATS under sufficient ammonium. In wild-type roots, ACTPK1 mRNA and protein accumulated dose-dependently under sufficient ammonium. To determine the function of ACTPK1, two independent mutants lacking ACTPK1 were produced by retrotransposon Tos17 insertion. Compared with segregants lacking insertions, the two mutants showed decreased root growth and increased shoot growth under 1 mm ammonium due to enhanced ammonium acquisition, via aberrantly high HATS activity, and use. Furthermore, introduction of OsACTPK1 cDNA fused to the synthetic green fluorescence protein under its own promoter complemented growth and the HATS influx, and suggested plasma membrane localization. Root cellular expression of OsACTPK1 also overlapped with that of ammonium-induced OsAMT1;1 and OsAMT1;2. Meanwhile, threonine-phosphorylated AMT1 levels were substantially decreased in roots of ACTPK1-deficient mutants grown under sufficient ammonium. Bimolecular fluorescence complementation assay further confirmed interaction between ACTPK1 and AMT1;2 at the cell plasma membrane. Overall, these findings suggest that ACTPK1 directly phosphorylates and inactivates AMT1;2 in rice seedling roots under sufficient ammonium.
Two Splicing Variants of OsNPF7.7 Regulate Shoot Branching and Nitrogen Utilization Efficiency in Rice

Rice includes 93 nitrate and peptide transporters family (NPF) members that facilitate the soil uptake and internal reallocation of nitrogen for growth and development. This study demonstrated that OsNPF7.7 had two splicing variants, and altered expression of each variant could regulate shoot branching and nitrogen utilization efficiency (NUtE) in rice. The expression of both variants was down-regulated in the buds by increased nitrogen level in the Japonica rice variety ZH11. The expression level of long-variant OsNPF7.7-1 was higher in panicles at reproductive stage, however, the expression level of short-variant OsNPF7.7-2 was higher in buds and leaves at vegetative stage compared to each other in ZH11. OsNPF7.7-1 was localized in the plasma membrane, whereas OsNPF7.7-2 was localized in the vacuole membrane. Furthermore, the results indicated that the expression level of each variant for OsNPF7.7 determined axillary bud outgrowth, and then influenced the rice tiller number. Overexpression of OsNPF7.7-1 could promote nitrate influx and concentration in root, whereas overexpression of OsNPF7.7-2 could improve ammonium influx and concentration in root. RNAi and osnpf7.7 lines of OsNPF7.7 showed an increased amount of amino acids in leaf sheaths, but a decreased amount in leaf blades, which affected nitrogen allocation and plant growth. The elevated expression of each variant for OsNPF7.7 in ZH11 enhanced NUtE using certain fertilization regimes under paddy field conditions. Moreover, overexpression of each variant for OsNPF7.7 in KY131 increased significantly the filled grain number per plant. Thus, increased each variant of OsNPF7.7 has the potential to improve grain yield and NUtE in rice.
Senior services in US hospitals and readmission risk in the Medicare population

Background There is a little understanding of the association between hospital organizational characteristics and hospital readmissions. We previously developed a Senior Care Services Scale (SCSS) that describes hospital availability of services relevant to the care of older adults. Objective Determine whether hospitals' SCSS scores were associated with risk of readmission among Medicare beneficiaries. Design Retrospective cohort analysis. Setting and Participants Medicare beneficiaries ≥65 years of age (n = 3 553 367), admitted to 5568 US acute-care hospitals in 2006, discharged alive. Medicare data were linked to the American Hospital Association database of hospital characteristics. Measurements All-cause non-elective hospital readmission, or death without readmission, within 30 days of hospital discharge. Results We examined the association between high and low scores of each of two hospital SCSS service groups: inpatient specialty care (IP) and post-acute (PA) community care. There was no association between high IP scores and readmission (RR 1.00, 95% CI 0.98-1.02). Older adults admitted to hospitals with high PA scores had lower risk of experiencing hospital readmission when compared to older adults admitted to hospitals with low PA scores (RR 0.97, 95% CI 0.95-0.98). High PA scores were associated with increased mortality (RR 1.09, 95% CI 1.06-1.13). In sensitivity analyses exploring relationships at 90 days, both the IP and PA subcomponents were associated with older adults' reduced risk of hospital readmission (IP: RR 0.97, 95% CI 0.95-0.99; PA: RR 0.97, 95% CI 0.95-0.99). Conclusion Senior services at the hospital-level represents a modifiable risk factor with important impact. Employing organization-level characteristics in readmission risk prediction tools should be expanded.
The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C)

Chemotherapeutic nucleoside analogs, such as Ara-C, 5-Fluorouracil (5-FU) and Trifluridine (FTD), are frequently incorporated into DNA by the replicative DNA polymerases. However, it remains unclear how this incorporation kills cycling cells. There are two possibilities: Nucleoside analog triphosphates inhibit the replicative DNA polymerases, and/or nucleotide analogs mis-incorporated into genomic DNA interfere with the next round of DNA synthesis as replicative DNA polymerases recognize them as template DNA lesions, arresting synthesis. To address the first possibility, we selectively disrupted the proofreading exonuclease activity of DNA polymerase ε (Polε), the leading-strand replicative polymerase in avian DT40 and human TK6 cell lines. To address the second, we disrupted RAD18, a gene involved in translesion DNA synthesis, a mechanism that relieves stalled replication. Strikingly, POLE1exo−/− cells, but not RAD18−/− cells, were hypersensitive to Ara-C, while RAD18−/− cells were hypersensitive to FTD. gH2AX focus formation following a pulse of Ara-C was immediate and did not progress into the next round of replication, while gH2AX focus formation following a pulse of 5-FU and FTD was delayed to the next round of replication. Biochemical studies indicate that human proofreading-deficient Polε-exo− holoenzyme incorporates Ara-CTP, but subsequently extend from this base several times less efficiently than from intact nucleotides. Together our results suggest that Ara-C acts by blocking extension of the nascent DNA strand and is counteracted by the proofreading activity of Polε, while 5-FU and FTD are efficiently incorporated but act as replication fork blocks in the subsequent S phase, which is counteracted by translesion synthesis.
Joint burst LASSO for sparse channel estimation in multi-user massive MIMO

The knowledge of CSI at the BS (CSIT) is required to achieve the high spectrum efficiency promised by massive MIMO. In Frequency-Division Duplex (FDD) Massive MIMO systems, the CSIT is obtained via downlink channel estimation and uplink channel feedback, However, the acquisition of CSIT is a very challenging problem in practical FDD massive MIMO systems with a large number of antennas. Recently, compressive sensing has been applied to reduce pilot and CSIT feedback overheads in massive MIMO systems by exploiting the underlying channel sparsity. However, standard sparse recovery algorithms have stringent requirement on the channel sparsity level for robust channel recovery and this severely limits the operating regime of the solution. To overcome this issue, we propose a joint burst LASSO algorithm to exploit additional joint burst-sparse structure in multi-user (MU) massive MIMO channels. Simulations show that the joint burst LASSO algorithm can alleviate the stringent requirement on the sparsity level for robust channel recovery and substantially enhance the channel estimation performance over existing solutions.
Emerging In Situ and Operando Nanoscale X‐Ray Imaging Techniques for Energy Storage Materials

Electrical vehicles (EVs) are an attractive option for moving towards a CO2 neutral transportation sector, but in order for widespread commercial use of EVs, the cost of electrical energy storage (i.e., batteries) must be reduced and the energy storage capacity must be increased. New, higher performing but Earth abundant electrodes are needed to accomplish this goal. To aid the development of these materials, in situ characterization to understand battery operation and failure is essential. Since electrodes are inherently heterogeneous, with a range of relevant length scales, imaging is a necessary component of the suite of characterization methods. In this Feature Article, the rapidly growing and developing field of X‐ray based microscopy (XM) techniques is described and reviewed focusing on in situ and operando adaptations. Further, in situ transmission electron microscopy (TEM) is briefly discussed in this context and its complement to XM is emphasized. Finally, a perspective is given on some emerging X‐ray based imaging approaches for energy storage materials.
Multi-layer network utilizing rewarded spike time dependent plasticity to learn a foraging task

Neural networks with a single plastic layer employing reward modulated spike time dependent plasticity (STDP) are capable of learning simple foraging tasks. Here we demonstrate advanced pattern discrimination and continuous learning in a network of spiking neurons with multiple plastic layers. The network utilized both reward modulated and non-reward modulated STDP and implemented multiple mechanisms for homeostatic regulation of synaptic efficacy, including heterosynaptic plasticity, gain control, output balancing, activity normalization of rewarded STDP and hard limits on synaptic strength. We found that addition of a hidden layer of neurons employing non-rewarded STDP created neurons that responded to the specific combinations of inputs and thus performed basic classification of the input patterns. When combined with a following layer of neurons implementing rewarded STDP, the network was able to learn, despite the absence of labeled training data, discrimination between rewarding patterns and the patterns designated as punishing. Synaptic noise allowed for trial-and-error learning that helped to identify the goal-oriented strategies which were effective in task solving. The study predicts a critical set of properties of the spiking neuronal network with STDP that was sufficient to solve a complex foraging task involving pattern classification and decision making.