Miracle-dz/UniFAR-FTUs huggingface dataset:
BubR1 is an effector of multiple mitotic kinases that specifies kinetochore: Microtubule attachments and checkpoint

BubR1 is a critical component of the mitotic checkpoint but has also been shown to play an essential role in establishing kinetochore:microtubule attachments. BubR1 is hyperphosphorylated in mitosis and recent studies in human and Xenopus have identified 9 phosphorylation sites. Plk1-dependent phosphorylations (T792, T1008 and S676) were reported to stimulate BubR1 kinase activity, promote kinetochore microtubule attachments, monitor kinetochore tension, as well as the recruitment of Mad2 checkpoint protein to kinetochores. Plk1-independent sites (S435, S543, S670 and S1043) were also identified and some of these were found to be sensitive to the loss of microtubule attachment but not tension. Functional studies showed that phosphorylation of S670 is critical for correcting aberrant attachments. Once end-on attachments are established, dephosphorylation of S670 appeared to be important for generating tension to signal anaphase onset. The collective data when combined with early EM studies that showed BubR1 is present at both the inner and outer kinetochore plates suggest that BubR1 maybe an effector of multiple kinases that specifies its roles in microtubule attachments and checkpoint functions.
Business Citizenship: From Domestic to Global Level of Analysis

Abstract: In this article we first review the development of the concept of global business citizenship and show how the libertarian political philosophy of free-market capitalism must give way to a communitarian view in order for the voluntaristic, local notion of “corporate citizenship” to take root. We then distinguish the concept of global business citizenship from “corporate citizenship” by showing how the former concept requires a transition from communitarian thinking to a position of universal human rights. In addition, we link global business citizenship to global business strategy and to three analytical levels of ethical norms. Finally, we trace a process whereby global businesses can implement fundamental norms and learn to accommodate to legitimate cultural differences.
Newer developments in the treatment of Gram-positive infections

Gram-positive organisms are continually a major cause of infection. These organisms are ever-evolving and exhibit resistance to nearly all available agents. Historically, vancomycin was crowned the drug of choice for many of these organisms including methicillin-resistant Staphylococcus aureus, penicillin-resistant Streptococcus pneumoniae, and penicillin-resistant Enterococcus spp. Many of these organisms have exhibited reduced susceptibility or frank resistance to vancomycin which has resulted in treatment failure. For this reason, new strategies in treating Gram-positive infections are a hot topic. There are two general approaches to waging this war: i) development of new antimicrobial agents; and ii) reinvigorating old antibiotics that still retain appreciable activity against Gram-positives. We review both antibiotic groupings with a focus on S. aureus, S. pneumoniae and Enterococcus spp.
Efficient vector perturbation in multi-antenna multi-user systems based on approximate integer relations

Approximate vector perturbation techniques assisted by LLL lattice reduction (LR) can exploit all the diversity that is available in multi-user multi-antenna broadcast systems. However, the required computational complexity of LLL-LR can be quite large. In this paper, we propose a much simpler and much more efficient LR algorithm than LLL. This LR technique is based on Brun's algorithm for finding approximate integer relations (IRs). The link between LR and IRs is established by considering poorly conditioned channels with a single small singular value. Simulation results show that our scheme can achieve large (but bot full) diversity at a fraction of the complexity required for LLL-assisted vector perturbation.
Differences between Danish and Swedish management

To most non‐Scandinavians Danes and Swedes are very much alike. The same language, the same social and democratic political system, and more or less the same history and culture. But there are differences which may be not observable to outsiders, but certainly are to the people involved. It is not the same managing an organisation in Sweden and Denmark. Based on personality tests data, this article confirm the perceived difference between the two groups. Swedish managers appear more organised, structured, and systematic, as they seek consensus through social processes. The individual strives for power and authority is on the group’s terms. The Danes are seen as more undisciplined and impulsive, with a tendency towards the anarchistic, because the individuals strive for power, authority and control more based on the individuals’ own terms.
Sampling-based tracking of time-varying channels for millimeter wave-band communications

In this paper, we propose a new recursive sparse channel recovery algorithm which can track time-varying support of angular domain channel response vector in mobility scenario for millimeter wave-band communications. We model the angle of departure (AoD) and the angle of arrival (AoA) using discrete state Markov random process and derive joint estimation of the time-varying support and amplitude of the angular domain channel vector. Using sequential Monte Carlo (SMC) method, the proposed channel estimation scheme tracks the support by drawing the samples from a posteriori distribution of the support indices while capturing the dynamics of time-varying amplitude using Kalman filter. Our simulation results show that the proposed algorithm yields significantly better tracking performance than the existing compressed sensing schemes.
Integrating Preference Assessment Within the Transition Process to Create Meaningful School-to-Life Outcomes

The Individuals With Disabilities Education Act mandates the provision of transition services to adolescent students with disabilities who are leaving school to enter the adult world. For students with severe disabilities who use limited symbolic or nonsymbolic communication, it may be difficult to accurately interpret desired school-to-life outcomes. The purpose of this article is to discuss the inclusion of systematic preference assessment within transition planning as a way to accurately interpret the preferences of students who use limited symbolic or nonsymbolic communication means. By using person-centered planning as a framework, this article illustrates how to embed preference assessment within transition planning so that the Individualized Education Program team can follow the leads and needs of the focus student. Special considerations are offered as they relate to preference assessment and transition planning.
Discovering second-order sub-structure associations in drug molecules for side-effect prediction

Possible drug side-effects (SEs) are usually verified by many years of repeated clinical trials. Despite the effort, some drugs are still expected to cause adverse reactions in some patients. To better predict drug SEs without having to go through the laborious processes of testing and re-testing, machine learning (ML) techniques are more and more used to uncovered patterns in drug data for such purpose. Most existing such techniques are black-box techniques. Since correlations between sub-structures involving multiple variables may exist, these techniques may not always work well. For ML techniques to be effective, they should be accurate, efficient and the patterns they discover should be interpretable. Towards these goals, we have developed a second-order association discovering (SOAD) algorithm for SE prediction. Given a set of drug data for training, the SOAD algorithm can discover SO associations between multiple drug sub-structures and multiple SEs in drug data for the purpose of predicting the SEs. SOAD performs its tasks by first making use of a residual measure to test the significance of occurrence of a chemical sub-structure within a drug and the SE of the drug. Once an association is established between a sub-structure and a SE, we test if two or more such sub-structures are significantly associated with a SE. Based on such second-order associations, we derive from them a set of “informative” SO patterns so that the SEs of new unseen drugs can be predicted based on the frequency of appearance of such patterns. To ensure interpretability of the SE discovery process, we make use of the Bayesian to predict if certain SO relationship in a drug may be related to a certain side-effect. Based on the experimental results, SOAD is found to be very promising.
Cortical representation of the horizon in V1 and peripheral scaling in mammals with lateral eyes

present investigation we mapped the primary visual area of the South American diurnal rodent, Dasyprocta aguti, by standardized electrophysiological mapping techniques. In particular, we performed a series of mapping experiments of the visual streak in the primary visual cortex. We found that the representation of the visual streak in V1 is greatly expanded, the nasal 10 degrees of the visual streak representation occupies ten times more cortical area than equivalent areas in the central or temporal representation. Comparison of these data with those on the density of ganglion cells in the retina at corresponding locations in the visual field reveal a significant mismatch between these two variables. The nasal representation is greatly expanded along the horizontal meridian in V1 as compared to the central and temporal regions whereas the density of ganglion cells decreases with progression along the visual streak from central region towards the nasal or temporal visual field. A review of the available data reveals that all lateral-eyed mammals exhibit a similar mismatch between the retinal and cortical representation of the visual field, and this mismatches is greater in those species with well defined visual streaks such as rabbit and agouti. KeyWords: horizontal meridian, V1 map, retinal ganglion cells, lateral-eyed mammals
Mandarin/English mixed-lingual name recognition for mobile phone

Speaker independent name speech recognition has become hot application in handheld devices such as mobile phones and personal digit assistants (PDAs). This paper presents a new mixed-lingual ASR system that will enable Chinese mobile phone users to conduct Mandarin and English name speech recognition simultaneously without switching language modes. We created an elaborately designed mixed acoustic model set which consists of two monolingual acoustic model sets, i.e. context-dependent Mandarin models and context-independent English models. Design of such mixed acoustic models for mobile phones is to balance the complexity and performance of the ASR system. We also described Mandarin and English mixed-lingual letter-to-sound converter in this paper. We demonstrated the effectiveness of the mixed-lingual name speech recognition system through off-line ASR experiments. Furthermore, the mixed-lingual name ASR system has also been integrated in Motorola new PDA phones and showed good performance in real world application .
Paradoxes of Modernity: Culture and Conduct in the Theory of Max Weber

Introduction Part I. Truth, Power, and Ethics: Max Weber's Political-Philosophical Profile: 1. Activity and renunciation: Max Weber on science and politics as vocations 2. Conviction and responsiblity: Max Weber on ethics Part II. Religion, Economy, and Politics: Max Weber's Historical-Sociological Profile 3. Hindrances to modernity: Max Weber on Islam 4. Hindrances to modernity: Max Weber on Western Christianity Epilogue: action, order and culture Notes Bibliography Index.
Performance study of IEEE 802.15.4 for industrial maintenance applications

Nowadays, a growing number of enterprises are adopting wireless technologies. However, field communications induce real-time constraints and those networks should at least fulfill those requirements. In this paper, we study IEEE 802.15. 4 performances in order to support industrial real-time traffic. This analysis brings out a comparative analysis of IEEE 802.15. 4 medium access methods. It provides also some limitations of that standard concerning cycle duration and amount of messages per cycle.
HDEER: A Distributed Routing Scheme for Energy-Efficient Networking

The proliferation of new online Internet services has substantially increased the energy consumption in wired networks, which has become a critical issue for Internet service providers. In this paper, we target the network-wide energy-saving problem by leveraging speed scaling as the energy-saving strategy. We propose a distributed routing scheme-HDEER-to improve network energy efficiency in a distributed manner without significantly compromising traffic delay. HDEER is a two-stage routing scheme where a simple distributed multipath finding algorithm is firstly performed to guarantee loop-free routing, and then a distributed routing algorithm is executed for energy-efficient routing in each node among the multiple loop-free paths. We conduct extensive experiments on the NS3 simulator and simulations with real network topologies in different scales under different traffic scenarios. Experiment results show that HDEER can reduce network energy consumption with a fair tradeoff between network energy consumption and traffic delay.
Factors associated with high cardiovascular risk in a primarily African American, urban HIV-infected population

Objective: To determine factors associated with increased risk of developing cardiovascular disease in a high-risk patient population. Design: Cross-sectional analysis of a retrospective cohort study. Methods: One-hundred patients at an inner city HIV clinic in 2008 were reviewed. The atherosclerotic vascular disease risk score was calculated using the Pooled Cohort Equation. Chi-square test was performed to identify associations of potential risk factors with elevated atherosclerotic vascular disease risk. Results: Eighty-one participants were included in the final analysis. In total, 95.1% were African American, and 38.3% were women. The median atherosclerotic vascular disease risk score was 8.8% and 8.1% in 2008 and 2012, respectively. The medical co-morbidities associated with increased atherosclerotic vascular disease risk were hepatitis C infection (X2 = 3.93; p value = 0.048), elevated triglycerides levels (X2 = 4.0; p value = 0.046), and low albumin (X2 = 4.65; p value = 0.031). There were a higher number of women with known atherosclerotic vascular disease despite lower median atherosclerotic vascular disease risk score compared to men. Conclusion: An elevated risk of developing cardiovascular disease persists in high-risk demographic groups of the HIV epidemic even in the current HIV era. There is an unexplained gender disparity and some non-traditional risk factors not accounted for in the Pooled Cohort Equation may be contributing to the excess cardiovascular disease risk observed among HIV-infected patients.
On the characterization of the Oracle for dynamic classifier selection

The Oracle model has been used not only for comparison between techniques but also in the design of different methods in Multiple Classifier Systems (MCS). Even though the model represents the ideal classifier selection scheme, Dynamic Classifier Selection (DCS) techniques present a large performance gap from the Oracle. This means that, for a significant number of instances, the DCS techniques are not able to select a competent classifier, despite the Oracles assurance of its presence in the pool. Given that issue, this work aims to investigate the reasons why the Oracle model may not be well suited for guiding the search for a promising pool of classifiers for DCS techniques. For this purpose, a pool generation method that guarantees an Oracle accuracy rate of 100% in the training set is proposed. This method is further used to analyse the behavior of DCS techniques when the presence of at least one competent classifier in the pool for each training sample is assured. Experiments show that integrating Oracle information in the generation phase of an MCS has little impact on the gap between the accuracy rates of DCS techniques and the Oracle. Moreover, it is also shown that, for a theoretical limit of 100%, the DCS techniques were only able to select a competent classifier for at most 85% of the instances, on average. Results suggest that the Oracle is not the best guide for generating a pool of classifiers for DCS, for the model is performed globally whilst DCS techniques work with local data only.
Efficacy of a Multicomponent Positive Psychology Self-Help Intervention: Study Protocol of a Randomized Controlled Trial

Background Positive psychology interventions have been found to enhance well-being and decrease clinical symptomatology. However, it is still unknown how flourishing can also be increased. Although multicomponent interventions seem to be necessary for this purpose, different formats can be used. A cost-effective approach could be a positive psychology-based self-help book with tailored email support to reach large target groups and to prevent dropout. Objective This study will evaluate the efficacy of a comprehensive multicomponent self-help intervention with or without email support on well-being and flourishing, and will seek to determine the working mechanisms underlying the intervention. Methods In this 3-armed, parallel, randomized controlled trial, 396 participants with low or moderate levels of well-being and without clinical symptomatology will be randomly assigned to (1) a self-help book condition with weekly email support, (2) a self-help book condition without email support but with a weekly information email, or (3) a waiting list control condition. Online measurements will be assessed at baseline, at post-test (3 months after baseline), and at 6 and 12 months after baseline. Results The primary outcomes are well-being and flourishing (ie, high levels of well-being). Secondary outcomes are the well-being components included in the intervention: positive emotion, use of strengths, optimism, self-compassion, resilience, and positive relations. Other measures include depressive and anxiety symptoms, personality traits, direct medical and non-medical costs, life-events, and client satisfaction. Conclusions This study will add knowledge to the efficacy and cost-effectiveness of a multicomponent positive psychology intervention. We will also explore who can benefit most from this intervention. If the intervention is found to be effective, our results will be especially relevant for public mental health services, governments, and primary care. Trial Registration The Netherlands Trial Register NTR4297; http://www.trialregister. nl/trialreg/admin/rctview.asp? TC=4297 (Archived by WebCite at http://webcitation.org/6Uwb5SUUM).
On the bilingual competence of Spanish heritage speakers: Syntax, lexical-semantics and processing

This study investigates the bilingual competence of adult simultaneous Spanish-English bilinguals living in the U.S. whose perceived weaker language is Spanish, and who are typically considered cases of language loss or incomplete acquisition. Potential Spanish language loss was assessed with respect to the grammar of monolingual Spanish speakers and with respect to the bilinguals' own competence in English, their perceived stronger language. The bilinguals took proficiency tests in Spanish and English. Four experiments tested the bilinguals' lexicosemantic and syntactic competence in Spanish and English. Experiments 1 and 2 used a Grammaticality Judgment Task in English and in Spanish to test syntactic and semantic aspects of unaccusative and unergative verbs, while Experiments 3 and 4 used an on-line visual probe recognition task to test semantic and syntactic aspects of these verbs in English and Spanish during sentence processing. Results of the linguistic and psycholinguistic measures show that despite self-perceptions and performance in the proficiency tests, the Spanish-English bilinguals were quite balanced in the two languages, and displayed robust knowledge of the syntactic effects of unaccusativity in English and Spanish. Variation from monolingual speakers was noticeable with the semantic classification of some verbs along the unaccusativity continuum (Sorace, 2000) as revealed in the Spanish tasks.
A Receptor Kinase-Like Protein Encoded by the Rice Disease Resistance Gene, Xa21

The rice Xa21 gene, which confers resistance to Xanthomonas oryzae pv. oryzae race 6, was isolated by positional cloning. Fifty transgenic rice plants carrying the cloned Xa21 gene display high levels of resistance to the pathogen. The sequence of the predicted protein, which carries both a leucine-rich repeat motif and a serine-threonine kinase-like domain, suggests a role in cell surface recognition of a pathogen ligand and subsequent activation of an intracellular defense response. Characterization of Xa21 should facilitate understanding of plant disease resistance and lead to engineered resistance in rice.
PLCE1 mRNA and Protein Expression and Survival of Patients with Esophageal Squamous Cell Carcinoma and Gastric Adenocarcinoma

Background: Germline genetic variants in PLCE1 (10q23) have demonstrated consistent associations with risk of esophageal squamous cell carcinoma (ESCC) and gastric cancer among Chinese. We evaluated PLCE1 mRNA and protein expression in paired tumor-normal tissues, and their relationship with survival. Methods: PLCE1 mRNA was profiled using three probes in the Affymetrix GeneChip U133 for paired tumor-normal tissues of ESCC (n = 132), gastric cardia adenocarcinoma (GCA, n = 62), and gastric noncardia adenocarcinoma (GNCA, n = 72). We used immunohistochemistry to detect PLCE1 protein on slides from tissue microarrays in paired tumor-normal tissues of ESCC (n = 303), and tumors of GCA (n = 298) and GNCA (n = 124). Results: Compared with normal tissues, PLCE1 mRNA expression was significantly reduced in ESCC tumors (P = 0.03, probe_205112_at), as well as in GCA and GNCA tumors (P < 0.0001, each probe). Protein expression was nonsignificantly reduced in ESCC tumors (P = 0.51). Increased tumor-normal mRNA fold change (probe_205112_at) was associated with longer survival in ESCC (9.6 months for highest vs. lowest quartile; Ptrend = 0.02). Increased mRNA tumor-normal fold change (probe_205111_at) was associated with longer survival for GCA (10.7 months for highest quartile; Ptrend = 0.04), but not for GNCA cases (P = 0.72). Similar to mRNA, elevated tumor-normal fold change for protein in ESCC was also associated with improved survival (8.1 months for highest quartile; Ptrend = 0.04). Conclusions: Dysregulated PLCE1 mRNA expression was observed for both ESCC (one probe only) and GCA tumors, and the altered PLCE1 expression seems to be associated with cancer prognosis. Impact: A potential role for PLCE1 in the early detection and/or therapy of ESCC and GCA warrants further investigation. Cancer Epidemiol Biomarkers Prev; 23(8); 1579–88. ©2014 AACR.