Miracle-dz/UniFAR-FTUs huggingface dataset:
The edentulous ridge expansion (ERE) technique an experimental study in the dog.

OBJECTIVE To compare the healing and bony crest resorption at implants installed conventionally or applying an edentulous ridge expansion (ERE) technique in the maxilla. MATERIAL AND METHODS In six Labrador dogs, the first and second maxillary incisors were extracted bilaterally. In the left side of the maxilla (Test), the flaps were elevated and the buccal plate of the alveoli and septa was removed. After 3 months of healing, partial-thickness (split) flaps were dissected and the residual alveolar bone was exposed. In the right side of the maxilla, an implant was installed conventionally (Type IV; Control) while, in the left side, the ERE technique was adopted. Hence, an expansion of the buccal bony crest was obtained, and the implant was subsequently installed (Test). After 3 months of healing, biopsies were obtained and ground sections were prepared for histological analyses. RESULTS A buccal vertical resorption of the bony crest of 2.2 ± 1.2 mm and 1.6 ± 0.7 mm was found at the test and control sites, respectively. The difference, however, did not reach statistical significance. The coronal level of osseointegration at the buccal aspect was located at 3.1 ± 1.0 mm and 2.2 ± 0.7 mm from the implant shoulder at the test and control sites, respectively, the difference being statistically significant. The mean values of the mineralized bone-to-implant contact (MBIC%) ranged from 43% to 48% at the buccal and lingual sites. No differences reached statistical significance. CONCLUSIONS Implants installed by applying an ERE technique may osseointegrate similarly to conventional implant installation. However, vertical and horizontal resorption of the displaced buccal bony wall occurred as well.
Trainers of technical professional higher education: Perceptions of their teaching

This study explored and analyzed the perceptions of technical training professionals. We centered on teachers of technical professional higher education in Chile who work for the industry and who teach in a part-time schedule. We described how their personal history, education, training, professional experience and resources affect their professional performance as teachers, as well as, the functions of planning, development and assessment of their teaching. The results showed that their tasks reflect models created from relationships with peers or from models that they bring from their preconceptions. A high level of technical expertise, which results in the training, is an element of motivation when teaching. We discuss the idea that while a good part-time teacher is somewhat of a personal achievement; it is also a result of operating model thanks provided by working groups, values, teaching methods, and constant learning.
Effect of Topical Antiglaucoma Drugs on Tear Film in Human Eyes

Objective(s): Evaluate the effect of topical antiglaucoma drugs on tear film and determine the time taken to develop symptoms and or signs of dry eye in diagnosed open angle glaucoma patients by Schirmer's test I, Schirmer's test II, Tear film break up time. Method(s): This prospective study was carried out in 60 patients attending Ophthalmology outdoor with newly diagnosed patients of primary open angle glaucoma by using Schirmer's test I, Schirmer's test II, Tear film break up time.These 60 cases were divided into 2 groups:- Group I: 30 cases were given 0.5% timolol drops twice a day and Group II: 30 cases were given 0.005% latanoprost drops once a day. Result(s): The tear film changes were greater in patients treated with timolol than with latanoprost. There were 11(36.7%) patients in timolol group and 3(10%) patients in latanoprost group which had developed dry eye at the end of the study period. Conclusion(s): Thus it is concluded that tear film changes are seen in significant number of patients of primary open angle glaucoma at the end of 90 th days follow up with both topical antiglaucoma drugs timolol and latanoprost therapy more so with timolol. These changes in the tear film were directly related to the duration of treatment.
Do perceived parental rearing patterns influence social behaviour dimensions and disease severity in schizophrenia?

In an explorative study, a clinical sample of 53 schizophrenic patients was examined. The EMBU inventory was used for measuring perceived parental rearing practices, the AfS for rating the quality of relationship to key relatives and the U‐Scale for assessing social anxiety. The findings obtained were intercorrelated and compared with 3 selected parameters of disease severity: age at first hospitalization, number of treated episodes and length of hospital stay. The results suggest that the quality of contact with key relatives is determined to a larger extent by the schizophrenia than by parental rearing attitudes. Rearing behaviour more likely influences the age at first hospitalization and social anxiety, whereas considering the length of face‐to‐face contact, the quality of the relationships between patients and their key relatives can be assumed to be associated with the duration of hospital stays.
The Yin and Yang of Immunomodulatory Biologics: Assessing the Delicate Balance between Benefit and Risk

A number of therapeutic immunomodulatory biologics, including antibodies, fusion proteins, and recombinant proteins, have been causally linked with serious adverse effects in humans. In nearly all cases, these serious adverse effects have been directly associated with the immunomodulatory biologic’s intended pharmacologic activity or exaggerated pharmacology. Examples of immunomodulatory biologics known to cause serious adverse effects in the clinic ranging from immunostimulation and cytokine release syndrome (e.g., TGN1412) to immunosuppression with increased risk of opportunistic infections (e.g., TNF-α antagonists, anti-integrins) are presented. Specific examples of the nonclinical testing strategy used for the clinical risk assessment of these immunomodulatory biologics are discussed, with an emphasis on the clinical relevance and predictivity of the models. Infectious challenge animal models, in particular, were critically evaluated for their utility in evaluating clinical risk assessment versus understanding mechanism of action. The nonclinical safety testing strategy for an immunomodulatory biologic should be custom tailored to interrogate the biology of the immunologic target in order to best assess potential clinical risk. This nonclinical strategy should include mechanistic and efficacy models of pharmacologic activity and immunologic signaling pathways, in vitro immunologic assays such as cytokine release, and immunophenotypic assessment by flow cytometry, immunohistochemistry, and/or immunofluorescence, as appropriate.
Target identification by a passive bistatic monochromatic wave Radar

A forward model of bistatic scattering by PEC infinite elliptic cylinder based on the Physical Optics (PO) approximation is presented. The model is obtained by applying the stationary phase method to the PO integrals in both TE and TM wave cases. The aim is to obtain the shape and size of 2D targets illuminated by a monochromatic wave bistatic Radar. A parameter estimation procedure based on the forward model is presented. Synthetic data are used to show the efficiency of the proposed method and the noise effect is also investigated.
Mathematical Driving Model of Three Phase, Two Level Inverter by (Method of Interconnected Subsystem)

In this paper describe to mathematical analysis for a three-phase, two level inverter designs. As we know the power electronic devices (inverter) to convert the DC power to AC power (controller on output voltage and frequency level). In Industrial applications, the inverters are used for adjustable speed (AC Drives). In this paper, the mathematical analyses for inverter design are done by using Software packages C++ Builder and visual C++ Language. For non- linear distortions described by the load power factor in power system networks. The P.F is reverse proportional with the harmonics distortion. Small P.F means much more of harmonic distortion, and lower power quality for consumers. to improve the P.F, and power quality in this paper the small capacitor installed as part of the rectified the load current has power (30 KW with P.F load 0.8), the fluctuations of the rectified voltage must not greater than +/- 10%. The power factor proportion of the load power, with Modulation coefficient p.u approximately unity. The calculation is achieved with different integrations steps with load power 30KW, 0.8 P.F. all results done Based on model and experimental data.
Prosocial preferences do not explain human cooperation in public-goods games

It has become an accepted paradigm that humans have “prosocial preferences” that lead to higher levels of cooperation than those that would maximize their personal financial gain. However, the existence of prosocial preferences has been inferred post hoc from the results of economic games, rather than with direct experimental tests. Here, we test how behavior in a public-goods game is influenced by knowledge of the consequences of actions for other players. We found that (i) individuals cooperate at similar levels, even when they are not informed that their behavior benefits others; (ii) an increased awareness of how cooperation benefits others leads to a reduction, rather than an increase, in the level of cooperation; and (iii) cooperation can be either lower or higher than expected, depending on experimental design. Overall, these results contradict the suggested role of the prosocial preferences hypothesis and show how the complexity of human behavior can lead to misleading conclusions from controlled laboratory experiments.
Validating Phenomenological Aspects of the Mental Imagery Experience through Meta-Analysis: Beyond Global Assessment of Imagery Ability

Two assessments of mental imagery vividness were compared through meta-analysis, the Vividness of Visual Imagery Questionnaire (VVIQ), and trial-by-trial ratings of vividness. Each vividness assessment was further divided into behavioural/cognitive or neuroscientific measures. It was found that the average effect size magnitude for trial-by-trial vividness exceeded that of the VVIQ for behavioural/cognitive, but not neuroscientific measures. However, the average effect sizes magnitude for neuroscientific measures was generally greater than behavioural/cognitive ones. Additionally, the average effect sizes magnitude for trial-by-trial vividness ratings was generally greater than the VVIQ. It is suggested that trial-by-trial ratings, in conjunction with neuroscientific measurement, may provide a more precise and reliable measure of mental imagery vividness. Despite face validity, unique observations correlating trial-by-trial vividness ratings with the VVIQ were weak to moderate on average. Theoretical considerations on the empirical validity of the construct of vividness are discussed.
A Phase Ib Study of Alpelisib (BYL719), a PI3Kα-Specific Inhibitor, with Letrozole in ER+/HER2− Metastatic Breast Cancer

Purpose: Alpelisib, a selective oral inhibitor of the class I PI3K catalytic subunit p110α, has shown synergistic antitumor activity with endocrine therapy against ER+/PIK3CA-mutated breast cancer cells. This phase Ib study evaluated alpelisib plus letrozole's safety, tolerability, and preliminary activity in patients with metastatic ER+ breast cancer refractory to endocrine therapy. Experimental Design: Twenty-six patients received letrozole and alpelisib daily. Outcomes were assessed by standard solid-tumor phase I methods. Tumor blocks were collected for DNA extraction and next-generation sequencing. Results: Alpelisib's maximum-tolerated dose (MTD) in combination with letrozole was 300 mg/d. Common drug-related adverse events included hyperglycemia, nausea, fatigue, diarrhea, and rash with dose-limiting toxicity occurring at 350 mg/d of alpelisib. The clinical benefit rate (lack of progression ≥6 months) was 35% (44% in patients with PIK3CA-mutated and 20% in PIK3CA wild-type tumors; 95% CI, 17%–56%), including five objective responses. Of eight patients remaining on treatment ≥12 months, six had tumors with a PIK3CA mutation. Among evaluable tumors, those with FGFR1/2 amplification and KRAS and TP53 mutations did not derive clinical benefit. Overexpression of FGFR1 in ER+/PIK3CA mutant breast cancer cells attenuated the response to alpelisib in vitro. Conclusions: The combination of letrozole and alpelisib was safe, with reversible toxicities. Clinical activity was observed independently of PIK3CA mutation status, although clinical benefit was seen in a higher proportion of patients with PIK3CA-mutated tumors. Phase II and III trials of alpelisib and endocrine therapy in patients with ER+ breast cancer are ongoing. Clin Cancer Res; 23(1); 26–34. ©2016 AACR.
Material Culture Across the Aleutian Archipelago

Abstract The material evidence from sites across the Aleutian Islands reflects colonization events, subsequent adaptations, and influxes of ideas and/or people from the east. The occurrence in the eastern Aleutians of bifacial technology around 7000 BP, of artifacts similar to the Arctic Small Tool tradition between 4000 and 3500 BP, and of slate and jet objects around 1000 BP reflects repeated surges of influence or movement of peoples from further east into the eastern end of the chain. In the central and western Aleutians, influence or perhaps colonization from east of the Aleutians is also marked by the occurrence of bifacial technology about 6500 BP and the appearance of slate artifacts after 1000 BP, suggesting the movement of ideas or people from further east. Basic trends across the archipelago include a decrease in formal chipped-stone tools, an increase in the use and the complexity of bone technology, and the increase in use and variety of ground-stone tools. In addition, increasing village site sizes and denser midden deposits are seen later in time throughout the archipelago. The similarity in sites and assemblages, albeit with regional variations, reflects trends that are seen across the chain and indicates that these island communities were not isolated from one another or from mainland Alaska.
CD38 Signaling Regulates B Lymphocyte Activation via a Phospholipase C (PLC)-γ2-Independent, Protein Kinase C, Phosphatidylcholine-PLC, and Phospholipase D-Dependent Signaling Cascade1

The CD38 cell surface receptor is a potent activator for splenic, B lymphocytes. The molecular mechanisms regulating this response, however, remain incompletely characterized. Activation of the nonreceptor tyrosine kinase, Btk, is essential for CD38 downstream signaling function. The major Btk-dependent substrate in B cells, phospholipase C-γ2 (PLC-γ2), functions to generate the key secondary messengers, inositol-1,4,5 trisphosphate and diacylglycerol. Surprisingly, CD38 ligation results in no detectable increase in phosphoinositide metabolism and only a minimal increase in cytosolic calcium. We hypothesized that Btk functioned independently of PLC-γ2 in the CD38 signaling pathway. Accordingly, we demonstrate that CD38 cross-linking does not result in the functional phosphorylation of PLC-γ2 nor an increase in inositol-1,4,5 trisphosphate production. Furthermore, splenic B cells exhibit a normal CD38-mediated, proliferative response in the presence of the phosphoinositide-PLC inhibitor, U73122. Conversely, protein kinase C (PKC) β-deficient mice, or PKC inhibitors, indicated the requirement for diacylglycerol-dependent PKC isoforms in this pathway. Loss of PKC activity blocked CD38-dependent, B cell proliferation, NF-κB activation, and subsequent expression of cyclin-D2. These results suggested that an alternate diacylglycerol-producing phospholipase must participate in CD38 signaling. Consistent with this idea, CD38 increased the enzymatic activity of the phosphatidylcholine (PC)-metabolizing enzymes, PC-PLC and phospholipase D. The PC-PLC inhibitor, D609, completely blocked CD38-dependent B cell proliferation, IκB-α degradation, and cyclin-D2 expression. Analysis of Btk mutant B cells demonstrated a partial requirement for Btk in the activation of both enzymes. Taken together, these data demonstrate that CD38 initiates a novel signaling cascade leading to Btk-, PC-PLC-, and phospholipase D-dependent, PLC-γ2-independent, B lymphocyte activation.
On the calculation of matrix exponential of a large order

Three approaches to calculating exponential of a matrix A = ||a<inf>gh</inf>|| of order n are considered: the approximation of the Taylor expansion, the method of polynomials of principal minors (PPM), and approximation by means of PPM. This methods are used in combination with scaling and squaring, if max|a<inf>gh</inf>| < 2/(n + 4). A comparison of above methods with Padé approximation is done. A new method for estimating the accuracy of calculations of the elements of a matrix exponential is proposed. It is based on the relative errors of the calculation of the maximum modulo element of the matrix expA.
Effect of clonidine and/or fentanyl in combination with intrathecal bupivacaine for lower limb surgery

Background and Aims: Various adjuncts to local anesthetics have been used with the purpose of improving the quality of subarachnoid block. This randomized double-blind study was conducted to evaluate the efficacy of adding clonidine to bupivacaine and bupivacaine-fentanyl combination. Material and Methods: A total of 100 patients scheduled for surgery under spinal anesthesia were randomly allocated into four groups (n = 25 each) to receive intrathecal bupivacaine 7.5 mg plus normal saline 0.5 ml (group BS), intrathecal bupivacaine 7.5 mg, and fentanyl 25 μg (group BF), intrathecal bupivacaine 7.5 mg and clonidine 75 μg (group BC), intrathecal bupivacaine 7.5 mg, clonidine 37.5 μg, and fentanyl 12.5 μg (group BCF). The time of onset and duration of sensory block, highest dermatome level of sensory block, time of onset of motor block, time to complete motor block recovery and duration of spinal anesthesia, intraoperative and postoperative hemodynamics and side effects if any were recorded. VAS, total number of patients who were administered supplemental analgesic in each group and the total amount of supplemental analgesic administered in the next 24 h was quantified and documented in all the groups. Results: The time of onset of sensory block (min) in groups BS, BC, BCF, and BF was 10.80 ± 2.26, 10.20 ± 1.00, 10.00 ± 0.00, and 13.80 ± 2.61 respectively, thus onset of sensory block was significantly earlier in groups BC and BCF. Similarly, onset of motor block was also quicker in groups BC and BCF. Time of requirement of supplemental analgesia was 135.20 ± 12.70 min, 199.2 ± 21.92 min, 209.80 ± 26.32 min, and 208.00 ± 26.58 min in groups BS, BF, BC, and BCF respectively. Intraoperative and postoperative changes in heart rate, mean arterial blood pressure, oxygen saturation, and respiratory rate were comparable. Sedation scores were significantly higher in group BC. Pruritus was only observed in groups BF and BCF. Mean nausea vomiting scores were comparable in all groups. Conclusion: We conclude that the addition of clonidine in doses of 75 μg and 37.5 μg to low-dose bupivacaine and bupivacaine-fentanyl prolongs the sensory and motor block while increasing the duration of postoperative analgesia without significant side-effects.
Syngeneic fibroblasts transfected with a plasmid encoding interleukin‐4 as non‐viral vectors for anti‐inflammatory gene therapy in collagen‐induced arthritis

No effective long‐term treatment is available for rheumatoid arthritis. Recent advances in gene therapy and cell therapy have demonstrated efficiency in collagen‐induced arthritis (CIA). Interleukin‐4 (IL‐4) is already known to be efficient in CIA in systemic injection or administered by gene therapy. This study was designed to evaluate the effect of a non‐viral gene therapy of CIA, involving injection of syngeneic fibroblasts transfected with a plasmid encoding for IL‐4.
Optimal delineation of single C-tactile and C-nociceptive afferents in humans by latency slowing

Human skin encodes a plethora of touch interactions, and affective tactile information is primarily signaled by slowly conducting C-mechanoreceptive afferents. We show that electrical stimulation of low-threshold C-tactile afferents produces markedly different patterns of activity compared with high-threshold C-mechanoreceptive nociceptors, although the populations overlap in their responses to mechanical stimulation. This fundamental distinction demonstrates a divergence in affective touch signaling from the first stage of sensory processing, having implications for the processing of interpersonal touch.
Performance analysis of 3φ DC-AC PECs with different switching schemes

This paper reviews the performance analysis of 3φ, 6-pulse, voltage source (VS) DC-AC power electronic converter (PEC) with different switching schemes. Among the pulse width modulation (PWM) techniques used for 3φ DC-AC 6-pulse PECs, Sinusoidal PWM (SPWM) is the easiest and oldest technique. Space Vector pulse width modulation (SVPWM) method is an advanced, computation intensive PWM method which is based on the concept of space vector made from the switching states of the PEC. Random pulse width modulation (RPWM) has become a viable alternative to PWM. Hysteresis Band Current Control (HBCC) is based on calculating the error between a reference output and the actual output of a converter. This paper aims to reveal the concepts, design, and switching sequence of SVPWM, SPWM, RPWM and HBCC implemented on a 3φ, 6-pulse DC-AC PEC on MATLAB/SIMULINK platform. The performance evaluation and comparison of each of these switching techniques has been presented in this paper. Developing an LC filter for reducing voltage total harmonic distortion (THDV) on the output-side of the PEC is another aim of this paper.
Muscle power patterns in the mid-acceleration phase of sprinting

To assess the role of the lower limb joints in generating velocity in the mid-acceleration phase of sprinting, muscle power patterns of the hip, knee and ankle were determined. Six male sprinters with a mean 100 m time of 10.75 s performed repeated maximal sprints along a 35 m indoor track. A complete stride across a force platform, positioned at approximately 14 m into the sprint, was video-recorded for analysis. Smoothed coordinate data were obtained from manual digitization of (50 Hz) video images and were then interpolated to match the sampling rate of the recorded ground reaction force (1000 Hz). The moment at each joint was then calculated using inverse dynamics and multiplied by the angular velocity to determine the muscle power. The results showed a proximal-to-distal timing in the generation of peak extensor power during stance at the hip, the knee and then the ankle, with the plantar flexors producing the greatest peak power. Apart from a moderate power generation peak towards toe-off, knee power was negligible despite a large extensor moment throughout stance. The role of the knee thus appears to be one of maintaining the centre of mass height and enabling the power generated at the hip to be transferred to the ankle.