Miracle-dz/UniFAR-FTUs huggingface dataset:
Unraveling the Complexity of Network Management

Operator interviews and anecdotal evidence suggest that an operator's ability to manage a network decreases as the network becomes more complex. However, there is currently no way to systematically quantify how complex a network's design is nor how complexity may impact network management activities. In this paper, we develop a suite of complexity models that describe the routing design and configuration of a network in a succinct fashion, abstracting away details of the underlying configuration languages. Our models, and the complexity metrics arising from them, capture the difficulty of configuring control and data plane behaviors on routers. They also measure the inherent complexity of the reachability constraints that a network implements via its routing design. Our models simplify network design and management by facilitating comparison between alternative designs for a network. We tested our models on seven networks, including four university networks and three enterprise networks. We validated the results through interviews with the operators of five of the networks, and we show that the metrics are predictive of the issues operators face when reconfiguring their networks.
Document Content Inventory & Retrieval

We give an analysis of relationships between expected retrieval performance and classification recognition accuracy in the context of document image content extraction and inventory. By content extraction we mean location and measurement of regions containing handwriting, machineprinted text, photographs, blank space, etc, in documents represented as bilevel, grey-level, or color images. Recent experiments have shown that even modest per-pixel content classification accuracies can support usefully high recall and precision rates (of, e.g., 80–90%) for retrieval queries within document collections seeking pages that contain a given minimum fraction of a certain type of content. In an effort to elucidate this interesting empirical result, we have analyzed the interdependency of classification and retrieval under a variety of assumptions about the distribution of content types in document image collections. We show that under general conditions we cannot derive precision and recall measures from per-pixel classification measures alone, but we can estimate the expected values of these measures. If however the distribution of content and error rates are uniform across the entire collection, our results suggest, it is possible to predict precision and recall measures from classification accuracy and vice versa.
Inhibition of Influenza M2-Induced Cell Death Alleviates Its Negative Contribution to Vaccination Efficiency

The effectiveness of recombinant vaccines encoding full-length M2 protein of influenza virus or its ectodomain (M2e) have previously been tested in a number of models with varying degrees of success. Recently, we reported a strong cytotoxic effect exhibited by M2 on mammalian cells in vitro. Here we demonstrated a decrease in protection when M2 was added to a DNA vaccination regimen that included influenza NP. Furthermore, we have constructed several fusion proteins of conserved genes of influenza virus and tested their expression in vitro and protective potential in vivo. The four-partite NP-M1-M2-NS1 fusion antigen that has M2 sequence engineered in the middle part of the composite protein was shown to not be cytotoxic in vitro. A three-partite fusion protein (consisting of NP, M1 and NS1) was expressed much more efficiently than the four-partite protein. Both of these constructs provided statistically significant protection upon DNA vaccination, with construct NP-M1-M2-NS1 being the most effective. We conclude that incorporation of M2 into a vaccination regimen may be beneficial only when its apparent cytotoxicity-linked negative effects are neutralized. The possible significance of this data for influenza vaccination regimens and preparations is discussed.
Study on the effect of corrosion on the tensile behavior of an AZ91 alloy

The effect of corrosion on the tensile behavior of an as‐cast AZ91 alloy was investigated via systematical experiments. The corrosion residual strength of the AZ91 magnesium alloy is approximately negative linear dependent on the extreme depth of corrosion pit, which was quantitatively obtained by the corrosion morphology analysis and the statistic analysis. Experimental results reveal that the corrosion residual strength of the AZ91 magnesium alloy dropped quickly in the first 40 h due to the initiation and development of the corrosion pit and subsequently decreased slowly as a result of the development of the corrosion pit encountered the β phase. The β phase at the grain boundary of the primary α phase acts as an effective barrier to prevent the development of the corrosion pit into the alloy matrix and thus remarkably prevents the drop of the corrosion residual strength. In general, the variation of the corrosion residual strength exhibits an exponential decay regulation within the testing time. Consequently, the empirical prediction of the corrosion residual strength was given with regard to the variation of the corrosion residual strength varied with the immersion time.
An Unexpected Presentation of Haemoperitoneum in a Pregnant Woman

In the majority of tertiary centres the Emergency Room or Assessment Unit is the gateway to the rest of the hospital. It is the location where critical decisions are formulated depending on whether a patient's condition is serious enough to warrant admission and, at times, emergency surgery. On occasion this decision can be straightforward based solely on the patient's presentation, observations, and basic investigations. This case highlights that although the decision and initial management may be apparent, often the diagnosis can be unexpected and that the diagnostic challenge is often outside the scope of a brief Emergency Room assessment. Corpus luteal cyst rupture is a common phenomenon but often not the cause of significant morbidity as it was in this case, especially in the absence of any associated risk factors.
The Reponse of Duck Erythrocytes to Norepinephrine and an Elevated Extracellular Potassium

This paper presents evidence that duck erythrocytes regulate their size in isotonic media by utilizing a previously reported "volume-controlling mechanism. " Two different experimental situations are examined. In the first, cells enlarge in a solution containing norepinephrine and an elevated [K]o; and in the second, enlarged cells shrink to their original size if the norepinephrine and excess potassium are removed. As the erythrocytes enlarge, K, Cl, and H2O accumulate. Shrinkage, in contrast, is accompanied by the controlled loss of K, Cl, and H2O. These changes and the associated changes in membrane permeability resemble those reported previously when duck erythrocytes incubate in anisotonic media. There cells, after first shrinking or swelling, utilize a "volume-controlling mechanism" to reestablish their original size. The mechanism regulates cell size by adjusting the total number of osmotically active intracellular particles. The present studies indicate duck red cells use this mechanism to readjust their total monovalent cation content and thus their solute content in isotonic media as well. In addition, evidence is presented which indicates that the "volume-controlling mechanism" and ouabain-inhibitable cation pump differ functionally.
Physical Activity Participation among Adult Nevadans with Self-Reported Asthma

Objective. This study looked at physical activity patterns among adults (≥ 18 years old) with self-reported asthma living in Nevada and investigated how physical inactivity is associated with asthma prevalence. Methods. We examined data from the 2009 Nevada Behavioral Risk Factor Surveillance System. Different physical activity measures among individuals were compared by asthma status. Results. Among 3840 respondents, 13.9% and 9.0% of them self-reported lifetime and current asthma, respectively. Significantly higher proportions of people with lifetime (12.9%) and current (17.7%) asthma did not engage in regular physical activity or exercise than those without lifetime (7.0%) and current (6.8%) asthma (p < .01). Over 30% of the respondents with asthma had no leisure-time physical activity compared with about 23% of those without asthma (p < .05). Moreover, these findings were statistically significant after adjusting for body mass index as well as other common sociodemographic variables. It was also found that asthmatic people spent significantly less time on moderate and vigorous physical activity than their nonasthmatic counterparts (223 minutes/week vs. 283 minutes/week for moderate physical activity; 214 minutes/week vs. 281 minutes/week for vigorous physical activity; p < .001). More than half of the respondents with asthma and close to half of those without asthma did not meet the current physical activity recommendation. Conclusion. A majority of adults with self-reported asthma living in Nevada are physically inactive. It appears that physical inactivity is associated with an increased prevalence of asthma.
Design Methodology for Domain Specific Parameterizable Particle Filter Realizations

This paper presents a reconfigurable particle filter design methodology for a real-time bearings-only tracking application. The methodology provides the capability of selecting a single particle filter from multiple particle filter realizations with maximum resource sharing. The autonomous buffer controller mechanism for the architecture ensures correct operation of the particle filters. Parameter adaptation and algorithm reconfiguration can be accomplished with negligible reconfiguration overhead through buffer controllers and a set of switches for transforming dataflow structures such that any desired particle filter can be implemented. Two target particle filters, sample importance resample filter (SIRF) and Gaussian particle filter (GPF), are realized using field programmable gate array (FPGA) based on the proposed methodology. However, the architecture can be extended for a wide range of particle filters with different sets of dynamics. This paper successfully demonstrates that implementation of a domain specific processor for particle filters is feasible with performance that is much higher than that of commercially available digital signal processors (DSPs).
Adherence and chemoprevention in major cardiovascular disease: a simulation study of the benefits of additional use of statins

Background In everyday practice, adherence to preventive medication for cardiovascular disease (CVD) is lower than in clinical trials and appears to decline to ∼50% by about 5 years. The UK body for the evaluation of health technologies, NICE, currently recommends that persons with a >20% 10-year risk of incident cardiovascular disease receive statins. Methods Publications on adherence to statin medication in clinical trials and in normal practice were systematically reviewed. Data on CVD-free members of a large southern hemisphere cohort study were used to simulate the expected benefits of contrasting strategies to increase the use of statins. Risks of incident CVD and death from CVD were estimated. Results A strategy to enhance statin adherence among cohort members meeting NICE statin-prescribing guidelines resulted in about twice as large a reduction in the aggregate risk of CVD death as did a strategy to lower treatment thresholds. Conclusions The benefits from increased spending on statin medication will be much greater if they result from enhanced adherence rather than from lowering the medication threshold.
Nesting Depth of Operators in Graph Database Queries: Expressiveness Vs. Evaluation Complexity

Designing query languages for graph structured data is an active field of research, where expressiveness and efficient algorithms for query evaluation are conflicting goals. To better handle dynamically changing data, recent work has been done on designing query languages that can compare values stored in the graph database, without hard coding the values in the query. The main idea is to allow variables in the query and bind the variables to values when evaluating the query. For query languages that bind variables only once, query evaluation is usually NP-complete. There are query languages that allow binding inside the scope of Kleene star operators, which can themselves be in the scope of bindings and so on. Uncontrolled nesting of binding and iteration within one another results in query evaluation being PSPACE-complete. We define a way to syntactically control the nesting depth of iterated bindings, and study how this affects expressiveness and efficiency of query evaluation. The result is an infinite, syntactically defined hierarchy of expressions. We prove that the corresponding language hierarchy is strict. Given an expression in the hierarchy, we prove that it is undecidable to check if there is a language equivalent expression at lower levels. We prove that evaluating a query based on an expression at level i can be done in $\Sigma_i$ in the polynomial time hierarchy. Satisfiability of quantified Boolean formulas can be reduced to query evaluation; we study the relationship between alternations in Boolean quantifiers and the depth of nesting of iterated bindings.
Medication non-adherence and asthma treatment cost

Purpose of reviewThe purpose of this review is to describe the impact of asthma treatment non-adherence on patients and the healthcare system, and to outline areas of responsibility towards improved adherence. Recent findingsThe average cost of healthcare expenses for each person in the United States in 2002 was US$5440. In that year, there were 800 million medical encounters. However, adherence research suggests that a significant portion of the healthcare advice and prescriptions dispensed in these encounters was wasted. The annual cost to the healthcare system caused by non-adherence has been estimated at US$300 billion dollars. The responsibility for improving adherence has usually been placed on the patient and healthcare provider. However, if non-adherence is to be more effectively addressed, other components of the healthcare and pharmaceutical industries must also take responsibility. SummaryTreatment non-adherence compromises treatment effectiveness and drives up the healthcare costs related to asthma and other chronic conditions. Collaborative efforts to improve adherence to treatments for chronic illness, recently promoted by the World Health Organization, must include multiple components of the healthcare system, must recognize that the costs of adherence promotion are outweighed by cost savings after improved adherence, and must support research to develop new and better strategies for improving adherence.
ENGINEERING PROPERTY REQUIREMENTS FOR STRUCTURAL ADHESIVES.

The subject of structural adhesive bonding is introduced by defining the main requirements for a successful joint, and by highlighting the important considerations for joint durability. The distinction is made between structural and semi-structural joints, and examples are given of structural steel-to-concrete bonding as used for the strengthening of buildings and bridge components in the UK. The body of the paper presents a proposed compliance spectrum for a two-part cold cure adhesive for the structural bonding of steel to concrete. The compliance spectrum outlines the chemical and physical form required of the adhesive and the necessary working characteristics while in the freshly mixed state. Mechanical properties of the hardened bulk adhesive and of steel-to-steel joints are specified, and appropriate test techniques described. In addition, requirements of the manufacturer in terms of providing quality control data, instruction sheets and packaging are proposed. The paper concludes by emphasizing the interdisciplinary understanding necessary for successful adhesive joint design, defining areas where further research is required and providing guidance as to where further information on the subject may be sought. (a)
Spontaneous Generalized Herpesvirus Hominis Infection of a Lowland Gorilla (Gorilla gorilla gorilla)

A 13‐day‐old lowland gorilla died from a generalized herpesvirus infection shortly after the onset of clinical signs. The pathologic‐anatomical findings were compatible with those described for generalized herpes simplex infection in the human neonate. Electron microscopic examination of lung tissue revealded the presence of herpesvirus which was identified with the fluorescent antibody technique as Herpes simplex virus type 1. Tests with related sera of the herpes group (varicella, herpesvirus‐B) revealed no specific immunofluorescence.
Implementing the ADVISE security modeling formalism in Möbius

The ADversary VIew Security Evaluation (ADVISE) model formalism provides a system security model from the perspective of an adversary. An ADVISE atomic model consists of an attack execution graph (AEG) composed of attack steps, system state variables, and attack goals, as well as an adversary profile that defines the abilities and interests of a particular adversary. The ADVISE formalism has been implemented as a Möbius atomic model formalism in order to leverage the existing set of mature modeling formalisms and solution techniques offered by Möbius. This tool paper explains the ADVISE implementation in Möbius and provides technical details for Möbius users who want to use ADVISE either alone or in combination with other modeling formalisms provided by Möbius.
Pharmacokinetics of sparfloxacin in broiler chicken

1. 1. The pharmacokinetics of sparfloxacin in broiler chicken was investigated following a single intravenous dose of 10 mg/kg and a single oral dose of 20 mg/kg. The pharmacokinetic parameters (AUC0−24 or C max) were integrated with the pharmacodynamic parameter (MIC90) to optimize sparfloxacin dosage in chicken. 2. 2. The apparent volume of distribution, total body clearance, mean residence time and elimination half-life following oral administration were 2·41 l/kg, 4·55 ml/min per kg, 10·54 and 5·94 h, respectively. Oral bioavailability was 61·7%. 3. Sparfloxacin was found to possess clinically useful pharmacokinetic properties. Based on pharmacokinetic/pharmacodynamic integration an oral dose of 20 mg/kg sparfloxacin for every 24 h might be recommended for a successful clinical effect in chickens.
Raman study of Epitaxial lateral Overgrowth of GaN on Patterned Sapphire Substrate

Structural and optical properties of gallium nitride (GaN) epilayers grown on lens shape patterned sapphire substrate (PSS) using metalorganic chemical vapor deposition (MOCVD) for various growth times were evaluated. From Raman spectra, a blue shift and reduction in the FWHM of Raman modes of GaN grown on PSS were observed when compared to GaN grown on unpatterend sapphire substrate (UPSS). From the DCXRD spectra, full width at half maximum (FWHM) value was decreased with increasing growth time. FWHM of the sample grown at 80 min was 473.5 arc sec. This indicates that there is an improvement in crystalline quality of the GaN grown on PSS as the growth time increases. From photoluminescence (PL) spectra, an increase in band edge emission intensity and a decrease in defect related yellow luminescence were observed for GaN on PSS as the growth time increased.
Differential loss and preservation of glutamate receptor function in bipolar cells in the rd10 mouse model of retinitis pigmentosa

Photoreceptor degenerations can trigger morphological alterations in second‐order neurons, however, the functional implications of such changes are not well known. We conducted a longitudinal study, using whole‐cell patch‐clamp, immunohistochemistry and electron microscopy to correlate physiological with anatomical changes in bipolar cells of the rd10 mouse – a model of autosomal recessive retinitis pigmentosa. Rod bipolar cells (RBCs) showed progressive changes in mGluR6‐induced currents with advancing rod photoreceptor degeneration. Significant changes in response amplitude and kinetics were observed as early as postnatal day (P)20, and by P45 the response amplitudes were reduced by 91%, and then remained relatively stable until 6 months. These functional changes correlated with the loss of rod photoreceptors and mGluR6 receptor expression. Moreover, we showed that RBCs make transient ectopic connections with cones during progression of the disease. At P45, ON‐cone bipolar cells (ON‐CBCs) retain mGluR6 responses for longer periods than the RBCs, but by about 6 months these cells also strongly downregulate mGluR6 expression. We propose that the relative longevity of mGluR6 responses in CBCs is due to the slower loss of the cones. In contrast, ionotropic glutamate receptor expression and function in OFF‐CBCs remains normal at 6 months despite the loss of synaptic input from cones. Thus, glutamate receptor expression is differentially regulated in bipolar cells, with the metabotropic receptors being absolutely dependent on synaptic input. These findings define the temporal window over which bipolar cells may be receptive to photoreceptor repair or replacement.
Subjective global assessment in patients with pulmonary tuberculosis.

BACKGROUND Malnutrition is observed frequently in patients with pulmonary tuberculosis (TB). Subjective global assessment (SGA) is a subjective method of measuring nutrition status. Few studies have investigated the prognostic role of SGA in patients with pulmonary TB. METHODS The authors evaluated 39 patients with pulmonary TB. The SGA classification technique was performed; patients were classified as well nourished (A), moderately malnourished (B), or severely malnourished (C). RESULTS The mean patient age was 67.7 ± 19.0 years, and the majority of patients were male (64.1% ). Twelve patients (30.1% ) were categorized as SGA class A, 14 patients (35.9% ) as class B, and 13 patients (33.3% ) as class C. The SGA-A group had a median survival of 438 days (95% confidence interval, 366-509), the median survival of the SGA-B group was 344 days (251-436), and the median survival of the SGA-C group was 118 days (37-198); these survival rates were significantly different (P < .001). CONCLUSION SGA appears to be a useful tool for nutrition assessment of patients with pulmonary TB. In addition, SGA may be a prognostic indicator of survival in patients with pulmonary TB.