Miracle-dz/UniFAR-FTUs huggingface dataset:
Myofibroblasts Induce Ectopic Activity in Cardiac Tissue

Focal ectopic activity in cardiac tissue is a key factor in the initiation and perpetuation of tachyarrhythmias. Because myofibroblasts as present in fibrotic remodeled myocardia and infarct scars depolarize cardiomyocytes by heterocellular electrotonic interactions via gap junctions in vitro, we investigated using strands of cultured ventricular cardiomyocytes coated with myofibroblasts, whether this interaction might give rise to depolarization-induced abnormal automaticity. Whereas uncoated cardiomyocyte strands were invariably quiescent, myofibroblasts induced synchronized spontaneous activity in a density dependent manner. Activations appeared at spatial myofibroblast densities >15.7% and involved more than 80% of the preparations at myofibroblast densities of 50%. Spontaneous activity was based on depolarization-induced automaticity as evidenced by: (1) suppression of activity by the sarcolemmal KATP channel opener P-1075; (2) induction of activity in current-clamped single cardiomyocytes undergoing depolarization to potentials similar to those induced by myofibroblasts in cardiomyocyte strands; and (3) induction of spontaneous activity in cardiomyocyte strands coated with connexin 43 transfected Hela cells but not with communication deficient HeLa wild-type cells. Apart from unveiling the mechanism underlying the hallmark of monolayer cultures of cardiomyocytes, ie, spontaneous electromechanical activity, these findings open the perspective that myofibroblasts present in structurally remodeled myocardia following pressure overload and infarction might contribute to arrhythmogenesis by induction of ectopic activity.
Influence of dietary urea level on digestive function and growth performance of cattle fed steam-flaked barley-based finishing diets.

Four Holstein steers (282 kg) with cannulas in the rumen and proximal duodenum were used in a 4 x 4 Latin square experiment to evaluate the influence of dietary urea level (0, 0.4, 0.8, and 1.2%, DM basis) in a steam-flaked barley-based finishing diet on digestive function. There were no treatment effects (P > 0.20) on ruminal digestion of OM and ADF. Increasing dietary urea level increased (linear, P < 0.01) ruminal starch digestion. Ruminal degradability of protein in the basal diet (no supplemental urea) was 60%. Increasing dietary urea level did not increase (P > 0.20) ruminal microbial protein synthesis or nonammonia N flow to the small intestine. There were no treatment effects (P > 0.20) on total-tract ADF digestion. Total tract digestion of OM (quadratic, P < 0.01) and starch (linear, P < 0.05) increased slightly with increasing urea level. Urea supplementation increased (linear, P < 0.01) ruminal pH 1 h after feeding; however, by 3 h after feeding, ruminal pH was lower (cubic, P < 0.05) with urea-supplemented diets. Urea supplementation did not affect (P > 0.20) ruminal molar proportions of acetate and propionate. One hundred twenty crossbred steers (252 kg; approximately 25% Brahman breeding) were used in an 84-d feeding trial (five pens per treatment) to evaluate treatment effects on growth performance. Daily weight gain increased (linear, P = 0.01) with increasing urea level, tending to be maximal (1.53 kg/d; quadratic, P = 0.13) at the 0.8% level of urea supplementation. Improvements in ADG were due to treatment effects (linear, P < 0.01) on DMI. Urea supplementation did not affect (P > 0.20) the NE value of the diet for maintenance and gain. Observed dietary NE values, based on growth performance, were in close agreement with expected based on tabular values for individual feed ingredients, averaging 100.4%. We conclude that with steam-flaked barely-based finishing diets, ruminal and total-tract digestion of OM and ruminal microbial protein synthesis may not be increased by urea supplementation. In contrast, ADG was optimized by dietary inclusion of 0.8% urea. Urea supplementation may not enhance the net energy value of steam-flaked barely-based finishing diets when degradable intake protein is greater than 85% of microbial protein synthesis.
New feminist stories of child sexual abuse : sexual scripts and dangerous dialogues

1. Introduction Part One: Theory 2. The 'Harm' Story in Childhood Sexual Abuse: Examining 'Help' for the Survivor of Child Sexual Abuse 3. Theorising Distress and Reproducing Disorder: Women, Child Sexual Abuse and Borderline Personality Disorder 4. Motivated Forgetting as Institutional Practice: False / Recovered as a Case Study 5. Child Sexual Abuse: Current Legal Issues 6. Representing Difference and Diversity: Traumatic Effects of Child Sexual Abuse Among 'Coloured' South African Women 7. Feminism's Restless Undead: The Radical / Lesbian / Victim Theorists Part Two: Practice 8. Appropriating Childhood: Child Sexual Abuse, Clinical Intervention, Child Protection and the Regulation of Experience and Identity 9. The Gender if News Production: Silenced Voices and False Memories 10. Child Sexual Abuse and the Practice of Cultural Imperialism 11. Psychology's Governance of the impact of Child Sexual Abuse 12. Identity, Gender and Participation in Self-Help Groups 13. Professional Discourses on Sexual Survival and the (re)production of Femininity 14. Clinical Story telling and Contemporary Dilemmas 15. Visible Therapy: Tactics for Addressing Child Abuse
Regulating Emotions: Culture, Social Necessity, and Biological Inheritance

Notes on Contributors. Foreword: Hans J. Markowitsch & Birgitt Rottger-Rossler. Acknowledgements. Introduction: Regulating Emotions: Culture, Social Necessity, and Biological Inheritance:. Marie Vandekerckhove (University of Brussels), Christian von Scheve (University of Vienna), Sven Ismer (University of Hamburg), Stefanie Kronast (Independent Consultant), and Susanne Jung (Independent Consultant). Part I: Emotion and Regulation: Between Culture and Biology:. 1. Psssst! Dr. Jekyll and Mr. Hyde are Actually the Same Person! A Tale of Regulation and Emotion: Arvid Kappas (Jacobs University Bremen). 2. Culture and Automatic Emotion Regulation: Iris B. Mauss (University of Denver), Silvia A. Bunge (University of California, Davis), and James J. Gross (Stanford University). 3. Emotion-Related Regulation: Biological and Cultural Bases: Claire Hofer and Nancy Eisenberg (both Arizona State University). Part II: Culture and Social Interaction: Markers in the Development of Emotion Regulation:. 4. Development of Emotion Regulation in Cultural Context: Gislea Trommsdorff (Konstanz University) and Fred Rothbaum (Tufts University). 5. Adult Attachment Theory, Emotion Regulation, and Prosocial Behavior: Phillip R. Shaver (University of California, Davis), Mario Mikulincer (Bar-Ilan University), and David Chun (University of California, Davis). 6. Themes in the Development of Emotion Regulation in Childhood and Adolescence and a Transactional Model: Maria von Salisch (University of Luneburg). Part III: What Is and What Ought To Be: Psychopathology and Emotion Regulation:. 7. Emotion Regulation and the Early Development of Psychopathology: Pamela M. Cole (Pennsylvania State University), Tracy A. Dennis (Hunter College, City University of New York), Sarah E. Martin (E.P. Bradley Hospital, Brown Medical School), and Sarah E. Hall (Pennsylvania State University). 8. Emotion Information Processing and Affect Regulation: Specificity Matters! : Pierre Philippot, Aurore Neumann, and Stephanie Delroisse (all Catholic University of Louvain at Louvain-la-Neuve). 9. Socio-Emotional Processing Competences: Assessment and Clinical Application: Martin Peper (University of Bern, University of Freiburg) and Roland Vauth (University of Basel). 10. Emotional Experience, Expression and Regulation in the Psychotherapeutic Processes: Leslie Greenberg (York University) and Marie Vandekerckhove (University of Brussels). Part IV: Setting the Stage: Culture and Society as Emotionally Regulated and Regulating Arenas:. 11. Passions as Cognitive and Moral Mistakes: The Case of Honor Killings in Europe: Unni Wikan (University of Oslo). 12. The Organizational Regulation of Anger: Poul Poder (University of Copenhagen). 13. Mood and Emotional Culture: A Study of Flow and Stress in Everyday Life: Charlotte Bloch (University of Copenhagen). Index.
TKLBLIIR: Detecting Twitter Paraphrases with TweetingJay

When tweeting on a topic, Twitter users often post messages that convey the same or similar meaning. We describe TweetingJay, a system for detecting paraphrases and semantic similarity of tweets, with which we participated in Task 1 of SemEval 2015. TweetingJay uses a supervised model that combines semantic overlap and word alignment features, previously shown to be effective for detecting semantic textual similarity. TweetingJay reaches 65.9% F1-score and ranked fourth among the 18 participating systems. We additionally provide an analysis of the dataset and point to some peculiarities of the evaluation setup.
Towards self-control of service rate for battery management in energy harvesting devices

We consider the operation of an energy harvesting wireless device (sensor node) powered by a rechargeable battery, taking non-idealities into account. In particular, we consider sudden decrease and increase of the battery level (leakage and charge recovery consequently) due to the inner diffusion processes in the battery. These processes are affecting the stability of the device operation. In particular, leakage accelerates the depletion of the battery, which results in inactive periods of the device and, thus, potential data loss. In this paper, we propose a simplified self-control management of a battery expressed by restrictions, which could be used for an efficient operational strategy of the device. To achieve this, we rely on the double-queue model which includes the imperfections of the battery operation and bi-dimensional battery value. This includes both apparent, i.e., available at the electrodes and true energy levels of a battery. These levels can be significantly different because of deep discharge events and can equalize thanks to charge recovery effect. We performed some simulation and observed that we can diminish the models variable number to predict possible unwanted events such as apparent discharge events (when the areas near electrodes are depleted while other areas of the battery still contain some energy) and data losses. This observation helps to achieve sufficiently effective self-control management by knowing and managing just few parameters, and therefore offers valuable directions for the development of autonomic and self-sustainable operation.
Evaluation of physico-chemical and functional properties of composite flour from cassava, rice, potato, soybean and xanthan gum as alternative of wheat flour.

This work aims at examining the physical, chemical and functional properties of composite flour produced with cassava, rice, soybean flours, and potato starch and added with 0.5% xanthan gum. Nine blends of composite flours were prepared by homogenously mixing rice flour, cassava flour, soybean flour, and potato starch (RF:CF:SF:PS) in the proportions of 30:50:15:4.5, 30:45:20:4.5, 30:40:25:4.5, 30:45:15:9.5, 30:40:20:9.5, 30:35:25:9.5, 30:40:15:14.5, 30:35:20:14.5, 30:30:25:14.5. Composite flour produces were subjected to proximate, paste and functional properties analyses. The moisture content, fat, protein, ash and crude fiber of the composites were as follows: 9.37-12.07% db, 1.33-4.91%, 4.50-6.22%, 0.74-1.12% and 1.13-1.94% compared with wheat flour 13.32% db, 6.30%, 2.12%, 1.31% and 7.52%, respectively. There was no significant difference (P > 0.05) recorded for water absorption index and gelatinization temperature between nine blends of composite flours and wheat flour. Peak, set back, cooling capacity and breakdown viscocisity were: 2311.67-4423.00 cP, 1199.33-1556.33 cP, 2618.67-3415.00 cP and 992.00-2437.67 cP. The value of composite flour viscosities were higher than paste characteristics of wheat flour. The colour of composite flour showed by the L * value of chromameter were 95.71-97.10 compared with wheat flour 95.02. Hence, it was concluded that the composite flours from rice, cassava, and soybean flour, potato starch using xanthan gum had the physicochemical and functional properties which can be considered similar to wheat flour for making wheatless products. The composite flour with the proportion of rice flour 30%, cassava flour 40%, potato starch 15%, soybean flour 14.5% and xanthan gum 0.5% had the physicochemical, functional and pasting properties that comparable to those of wheat flour.
A generalized signal reconstruction method for designing interpolation filters

A generalized signal reconstruction method is presented for the development of digital FIR interpolation filters, applicable to an analog reconstruction filter impulse response with finite duration that extends to an integer number of the input sampling periods. The technique produces efficient interpolation filter structures for both polynomial and non-polynomial based impulse responses, and could minimize implementation requirements (area, power) for filter designs involving sampling rate conversion
An Incremental Learning Algorithm of Ensemble Classifier Systems

In this paper, we propose an incremental learning model for ensemble classifier systems. In the proposed model, the number of classifiers is predetermined and fixed during the learning, and all classifiers are updated at every learning stage based on an extended algorithm of AdaBoost.Ml. A neural network model called resource allocating network with long-term memory (RAN-LTM), which has been developed to realize stable incremental learning, is adopted as a classifier. We also propose a new method to update the classifier weights in the weighted majority voting under the one-pass incremental learning situations. In the experiments, first we verify that the proposed model can learn incrementally without serious forgetting and that the performance is not influenced seriously by the size of a training subset given at every learning stage. Then, through a comparison with resource allocating network (RAN), RAN-LTM, and AdaBoostMl, we demonstrate that the proposed incremental ensemble classifier system has comparable performance with a batch-learning ensemble classifier system, and that it outperforms both batch-learning and incremental-learning single-classifier systems.
Web-Mediated Communication: in Search of Togetherness

This paper introduces a community-based video sharing environment to support asynchronous communication among heterogeneous participants within a restricted social community. Unlike other community sharing efforts, our work is predicated on the desire to strengthen existing strong ties among group members, in which existing relationships can be nurtured. Using the applications model of a high school concert as a starting point, this paper discusses a sharing framework in which highly personalized music videos are constructed from a collection of independent parent-made recordings. The environment addresses a series of parent needs for producing tailored presentations with custom features, based on ‘safe sharing’ of common assets. We report on the user needs determined by a number of focus groups and on a web-based environment that can be used to manage the complex inter-personal relationships and time-variant social contexts with a community of diverse (but related) users.
NatServer: A Client-Server Architecture for building Parallel Corpora applications

espanolLos corpora paralelos son importantes para la mayoria de las tareas de procesamiento de Lenguaje Natural. Gran parte de los investigadores utilizan los corpora paralelos empleandolos en aplicaciones comunes, como la traduccion maquina, y en tareas monolinguisticas, como sean la deteccion de parafrasis y la resolucion de problemas de ambiguedad semantica. Este trabajo ha sido orientado por estas cuestiones y propone una arquitectura cliente-servidor de interrogacion eficiente de corpora paralelos y diccionarios de traduccion probabilistica. EnglishParallel corpora are important resources for most Natural Language processing tasks. From the common applications, like machine translation, to the usually mono-lingual tasks as paraphrase detection and word sense disambiguation, most researchers are using massive parallel corpora. Thus, the availability of an efficient way to manage them is very important. This paper presents a Client- Server architecture to query efficiently parallel corpora and probabilistic translation dictionaries.
Preparative Scale Resolution of Enantiomers Enables Accelerated Drug Discovery and Development

The provision of pure enantiomers is of increasing importance not only for the pharmaceutical industry but also for agro-chemistry and biotechnology. In drug discovery and development, the enantiomers of a chiral drug depict unique chemical and pharmacological behaviors in a chiral environment, such as the human body, in which the stereochemistry of the chiral drugs determines their pharmacokinetic, pharmacodynamic and toxicological properties. We present a number of challenging case studies of up-to-kilogram separations of racemic or enriched isomer mixtures using preparative liquid chromatography and super critical fluid chromatography to generate individual enantiomers that have enabled the development of new candidate drugs within AstraZeneca. The combination of chromatography and racemization as well as strategies on when to apply preparative chiral chromatography of enantiomers in a multi-step synthesis of a drug compound can further facilitate accelerated drug discovery and the early clinical evaluation of the drug candidates.
Concurrent sequential patterns mining and frequent partial orders modelling

Structural relation patterns have been introduced to extend the search for complex patterns often hidden behind large sequences of data, with applications (e.g.) in the analysis of customer behaviour, bioinformatics and web mining. In the overall context of frequent itemset mining, the focus of attention in the structural relation patterns family has been on the mining of concurrent sequential patterns, where a companion approach to graph-based modelling can be illuminating. The crux of this paper sets out to establish the connection between concurrent sequential patterns and frequent partial orders, which are well known for discovering ordering information from sequence databases. It is shown that frequent partial orders can be derived from concurrent sequential patterns, under certain conditions, and worked examples highlight the relationship. Experiments with real and synthetic datasets contrast the results of the data mining and modelling involved.
Modeling and simulation of critical infrastructures

While the knowledge of human operators and stakeholders is becoming more and more sector specifi c, infrastructures are becoming more and more interoperable and interdependent. Hence representing the behavior and the characteristics of such a scenario is a mandatory task, in order to assess the risk of multiple disruptions and domino effects, and in order to provide adequate policies and countermeasures to react to structural vulnerabilities, failures, or even intentional attacks. In the literature many approaches have been proposed; holistic methods consider infrastructures with an high level of abstraction, while topological frameworks consider the interaction of multiple homogeneous subsystems. Nevertheless, simulative approaches are focused on a detailed representation of isolated subsystems or agents, evaluating their interaction by means of simulation platforms. Finally multilayer methodologies consider interconnected agents according to multiple levels of abstraction or perspectives.
Intralesional therapy with anti-CD20 monoclonal antibody rituximab in primary cutaneous B-cell lymphoma.

BACKGROUND We report the use of a new treatment modality in 2 patients with primary cutaneous B-cell lymphoma. In a 58-year-old woman with progressive nodular lesions on the scalp and face, several treatment attempts either failed or could not be used because of severe adverse effects and underlying epilepsy. The patient declined radiotherapy. A 30-year-old man presented with recurrence of tumor nodules occipitally, thoracically, on the arm, and on the right thigh after several excisions. OBSERVATIONS Intralesional injection of rituximab, a chimeric antibody directed against the CD20 transmembrane antigen present in malignant and normal B cells, resulted in partial regression of tumor nodules. No adverse effects occurred except pain during or shortly after injection and, in one patient, a slight rise in body temperature. Due to the treatment a prolonged complete disappearance of B cells from peripheral blood samples was observed. CONCLUSION Intralesional rituximab therapy is a nontoxic and effective treatment for cutaneous B-cell lymphoma that deserves further investigation in larger clinical trials.
MIMO radar demystified and where it makes sense to use

Contrary to claims made Multiple Input and Multiple Output (MIMO) radars do not provide an order of magnitude or better angle resolution, accuracy and identifiability (the ability to resolve and identify targets) over conventional radars. This claim is based on using a MIMO array radar system consisting of a full transmit array and thinned receive array (or vice versa; called here a full/thin array). This claim for MIMO results from making the wrong comparison to a full conventional array rather than to a conventional full/thin array. It is shown here that a conventional full/thin array radar can have the same angle accuracy, resolution and identifiability as a MIMO full/thin array. Where does the MIMO radar provide a better angle accuracy than a conventional radar? A monostatic MIMO array radar does provide a better angle accuracy than its conventional monostatic equivalent, but it is only about a factor of 1/√2 (29 percent) better and its resolution is the same.
Symbiosis in Subterranean Termites: A Review of Insights from Molecular Studies

ABSTRACT The symbiotic relationship of termites and their eukaryotic and prokaryotic gut microbiota is a focal point of research because of the important roles symbionts play in termite nutrition. The use of molecular methods has recently provided valuable insights into the species diversity and the roles of microorganisms in the guts of termites. This paper provides a review of the current knowledge of symbiont species inventories, genome analysis, and gene expression in the guts of subterranean termites. Particular emphasis is given to the termite genera Reticulitermes and Coptotermes (Isoptera: Rhinotermitidae), because they contain pest species of global impact in their native and invasive range.
MicroRNA‐106b modulates epithelial–mesenchymal transition by targeting TWIST1 in invasive endometrial cancer cell lines

Type II endometrial carcinoma is an aggressive subtype of endometrial cancer (EC). TWIST1, a helix‐loop‐helix transcription regulator, is known to induce epithelial–mesenchymal transition (EMT) and promote tumor metastasis. MicroRNAs (miRNAs) also serve as important regulators of EMT and metastasis by regulating EMT‐related genes. In this study, we sought to explore the role of TWIST1 in inducing EMT in representative type II EC cell lines, and to determine the miRNAs involved in regulating TWIST1 gene expression. Functional analysis suggested that TWIST1 contributes to the EMT phenotypes of EC cells, as evidenced by the acquisition of fibroblast‐like properties, enhanced invasiveness, and induction of an EN‐switch (downregulation of epithelial marker E‐cadherin and upregulation of mesenchymal marker N‐cadherin). Conversely, silencing of TWIST1 by siRNA inhibited cell invasion and the mesenchymal phenotype, which was accompanied by a reversion of the EN‐switch. We also observed a novel post‐transcriptional regulatory mechanism of TWIST1 expression mediated by miR‐106b via its direct interaction with TWIST1 mRNAs at the 3′‐untranslated region. Our data suggest that TWIST1 is a critical inducer of EMT in invasive EC cells and that miR‐106b could suppress EC cell invasion by downregulating TWIST1 expression. © 2013 Wiley Periodicals, Inc.