Miracle-dz/UniFAR-FTUs huggingface dataset:
Microplane constitutive model for porous isotropic rocks

The paper deals with constitutive modelling of contiguous rock located between rock joints. A fully explicit kinematically constrained microplane‐type constitutive model for hardening and softening non‐linear triaxial behaviour of isotropic porous rock is developed. The microplane framework, in which the constitutive relation is expressed in terms of stress and strain vectors rather than tensors, makes it possible to model various microstructural physical mechanisms associated with oriented internal surfaces, such as cracking, slip, friction and splitting of a particular orientation. Formulation of the constitutive relation is facilitated by the fact that it is decoupled from the tensorial invariance restrictions, which are satisfied automatically. In its basic features, the present model is similar to the recently developed microplane model M4 for concrete, but there are significant improvements and modifications. They include a realistic simulation of (1) the effects of pore collapse on the volume changes during triaxial loading and on the reduction of frictional strength, (2) recovery of frictional strength during shearing, and (3) the shear‐enhanced compaction in triaxial tests, manifested by a deviation from the hydrostatic stress–strain curve. The model is calibrated by optimal fitting of extensive triaxial test data for Salem limestone, and good fits are demonstrated. Although these data do not cover the entire range of behaviour, credence in broad capabilities of the model is lend by its similarity to model M4 for concrete—an artificial rock. The model is intended for large explicit finite‐element programs. Copyright © 2002 John Wiley & Sons, Ltd.
Mixtures Composed of Liquid Crystals and Nanoparticles

The past decade has witnessed an increased interest in the study of mixtures [1–3] of various soft materials and nanoparticles. A characteristic feature of a nanoparticle is that at least one of its dimensions is limited to between 1 and 100 nm. It is of interest to find combinations where each component introduces a qualitatively different behavior into the system. Such systems are expected to play an important role in the emerging field of nanotechnology and also in composites with extraordinary material properties.
On the Pagenumber of k-Trees

A $p$-page embedding of a graph $G$ is a vertex-ordering $\pi$ of $V(G)$ (along the “spine” of a book) and an assignment of edges to $p$ half-planes (called “pages”) such that no page contains crossing edges (alternating endpoints) relative to $\pi$. The pagenumber of $G$ is the least $p$ such that $G$ has a $p$-page embedding. We disprove a conjecture of Ganley and Heath by showing that when $k\geq3$, there are $k$-trees that do not embed in $k$ pages. We also present an algorithm that produces $k$-page embeddings for $k$-trees in a special class.
Alteration of Visual Input Results in a Coordinated Reorganization of Multiple Visual Cortex Maps

In the adult visual cortex, multiple feature maps exist and have characteristic spatial relationships with one another. The relationships can be reproduced by “dimension-reduction” computational models, suggesting that the principles of continuity and coverage may underlie cortical map organization. However, the mechanisms responsible for establishing these relationships are unknown. We explored whether removing one feature map during development causes a coordinated reorganization of the remaining maps or whether the remaining maps are unaffected. We removed the ocular dominance map by monocular enucleation in newborn ferrets, so that single eye stimulation drove the cortex in a more spatially uniform manner in adult monocular animals compared with normal animals. Maps of orientation, spatial frequency, and retinotopy formed in monocular ferrets, but their structures and spatial relationships differed from those in normal ferrets. The wavelength of the orientation map increased, so that the average orientation gradient across the cortex decreased. The decrease in the orientation gradient in monocular animals was most prominent in the high gradient regions of the spatial frequency map, indicating a coordinated reorganization between these two maps. In monocular animals, the orthogonal relationship between the orientation and spatial frequency maps was preserved, and the orthogonal relationship between the orientation and retinotopic maps became more pronounced. These results were consistent with detailed predictions of a dimension-reduction model of cortical organization. Thus, the number of feature maps in a cortical area influences the relationships between them, and inputs to the cortex have a significant role in generating these relationships.
A Low-Cost Framework for Individualized Interactive Telerehabilitation

In this paper we examine the issues pertaining to development of a low-cost telerehabilitation framework for upper-limb dysfunction, that is suitable for deployment in patients' homes. We use the example of a Virtual Driving Environment (VDE) to present the overall architecture and discuss issues of: (i) quantitative data-acquisition using commercial-off-the-shelf gaming devices; (ii) model-based parametric data transmission/playback; and (iii) parametric biomechanical identification and data reduction; to support individualization within the telerehabilitation regimen.
VEGFA-dependent and -independent pathways synergise to drive Scl expression and initiate programming of the blood stem cell lineage in Xenopus

The first haematopoietic stem cells share a common origin with the dorsal aorta and derive from putative adult haemangioblasts in the dorsal lateral plate (DLP) mesoderm. Here we show that the transcription factor (TF) stem cell leukaemia (Scl/Tal1) is crucial for development of these adult haemangioblasts in Xenopus and establish the regulatory cascade controlling its expression. We show that VEGFA produced in the somites is required to initiate adult haemangioblast programming in the adjacent DLP by establishing endogenous VEGFA signalling. This response depends on expression of the VEGF receptor Flk1, driven by Fli1 and Gata2. Scl activation requires synergy between this VEGFA-controlled pathway and a VEGFA-independent pathway controlled by Fli1, Gata2 and Etv2/Etsrp/ER71, which also drives expression of the Scl partner Lmo2. Thus, the two ETS factors Fli1 and Etv6, which drives the VEGFA expression in both somites and the DLP, sit at the top of the adult haemangioblast gene regulatory network (GRN). Furthermore, Gata2 is initially activated by Fli1 but later maintained by another ETS factor, Etv2. We also establish that Flk1 and Etv2 act independently in the two pathways to Scl activation. Thus, detailed temporal, epistatic measurements of key TFs and VEGFA plus its receptor have enabled us to build a Xenopus adult haemangioblast GRN.
A simplifying method of vision attention simulating human vision in machine vision system

In recent years, research of human vision attention opens a new field for machine vision. A novel and simplified model including saccade and gaze is presented in this paper, which simulates human vision attention. An efficient algorithm is proposed for extracting simple features in global scene and extracting candidate features in local saliency region so as to reduce computational cost. This simplified method is very reliable in some cases of machine vision system and is nearly equivalent to that obtained from human vision attention.
Radiographic Assessment of Adult Flatfoot

Background: The accurate measurement of flatfoot on standing radiographs allows correct diagnosis of the condition and evaluation of reconstructive procedures. Method: The standing radiographic measurements of patients with symptomatic, adult flatfoot were compared to controls using blinded observers.Results: On the lateral radiograph, the talar-to-first metatarsal angle, the calcaneal pitch angle, and the medial cuneiform-fifth metatarsal height differed significantly between the patient group and the controls. The difference in the talar-to-first metatarsal angles on lateral radiographs was the most statistically significant (patient group 21.1 ±10.8 degrees and control 7.1 ± 10.7 degrees, p < 0.0001) with good correlation between readings (intraobserver 0.75, interobserver 0.83). On the anteroposterior (AP) radiograph, the talar head uncoverage distance was the most significantly different measurement between these groups. Conclusions: These findings support the hypothesis that the talar-first metatarsal angle is an accurate radiographic identifier of patients with symptomatic, adult flatfoot.
Does virus–bacteria coinfection increase the clinical severity of acute respiratory infection?

This retrospective cohort study investigated the presence of bacteria in respiratory secretions of patients hospitalized with acute respiratory infections and analyzed the impact of viral and bacterial coinfection on severity and the mortality rate. A total of 169 patients with acute respiratory infections were included, viruses and bacteria in respiratory samples were detected using molecular methods. Among all samples, 73.3% and 59.7% were positive for viruses and bacteria, respectively; 45% contained both virus and bacteria. Bacterial coinfection was more frequent in patients infected by community respiratory viruses than influenza A H1N1pdm (83.3% vs. 40.6%). The most frequently bacteria detected were Streptococcus pneumoniae and Haemophilus influenzae. Both species were co‐detected in 54 patients and identified alone in 22 and 21 patients, respectively. Overall, there were no significant differences in the period of hospitalization, severity, or mortality rate between patients infected with respiratory viruses alone and those coinfected by viruses and bacteria. The detection of mixed respiratory pathogens is frequent in hospitalized patients with acute respiratory infections, but its impact on the clinical outcome does not appear substantial. However, it should be noted that most of the patients received broad‐spectrum antibiotic therapy, which may have contributed to this favorable outcome. J. Med. Virol. 87:1456–1461, 2015. © 2015 Wiley Periodicals, Inc.
Artificial Skin Tactile Sensor For Prosthetic and Robotic Applications

To solve the problem of limited tactile sensing in humanoid robotics as well as provide for future planned mechanical prostheses, an innovative tactile sensor system was created and embedded into two realistic-looking artificial skin gloves. These artificial skin tactile sensors used small piezoelectric ceramic disks to measure applied force at multiple points on each glove. The gloves were created using silicone rubber to simulate both the texture and look of human skin, while maintaining both flexibility and durability. The sensor outputs were buffered by high-impedance voltage-following operational amplifiers, and then read sequentially using a multiplexing scheme by a microcontroller. Sensor data were sent via USB to a computer, where a graphical user display was created to show the tactile information in real time. These prototypes successfully demonstrated the viability of small piezoelectric elements embedded in silicone rubber for use in creating flexible and elastic tactile sensors. members of my thesis committee, whose knowledge and aid helped in overcoming several technical hurdles QL+ and its members, for funding this project and freely lending their knowledge of the application of realistic-looking silicone rubber, which gave this project its visual elegance
A Circuit Compatible Analytical Device Model for Nanowire FET Considering Ballistic and Drift-Diffusion Transport

In this paper, we propose a quasi-analytical device model of nanowire FET (NWFET) for both ballistic and drift-diffusion current transport, which can be used in any conventional circuit simulator like SPICE. The closed form expressions for I-V and C-V characteristics are obtained by analytically solving device equations with appropriate approximations. The developed model was further verified with the measured I-V characteristics of a NWFET device. Results show a close match of the model with measured data.
CluE: An Algorithm for Expanding Clustered Graphs

In this paper, we present an algorithm, called CluE (The Cluster Expander of Compound Graphs), that expands cluster nodes in compound graphs. CluE was designed to work with multiple layout algorithms (e.g., orthogonal layout algorithm, Sugyima layout algorithm, etc.). It keeps the unexpanded nodes in their relative layers with slight changes in their original coordination. This helps the users in maintaining their mental map of the underlying graph. We applied the proposed algorithm for navigating through compound graphs representing the failure mechanisms in embedded systems. We also performed a brief user evaluation study in order to measure the users' acceptance level with regard to the application of CluE for compound graphs. Results show a high acceptance ratio from users having different backgrounds, which indicates the intuitiveness and feasibility of our approach.
Actor-recipient role affects neural responses to self in emotional situations

People often take either the role of an actor or that of recipient in positive and negative interpersonal events when they interact with others. The present study investigated how the actor-recipient role affected the neural responses to self in emotional situations. Twenty-five participants were scanned while they were presented with positive and negative interpersonal events and were asked to rate the degree to which the actor/the recipient was that kind of person who caused the interpersonal event. Half of the trials were self-relevant events and the other half were other-relevant events. Results showed that people were more likely to isolate self from negative events when they played the role of actor relative to recipient. Pregenual anterior cingulate cortex (pgACC) and posterior dorsal anterior cingulate cortex (pdACC) were more active for self than other only in negative events. More importantly, also in negative interpersonal events, dorsal medial prefrontal cortex (dmPFC) showed greater self-related activations (self-other) when participants played the role of recipient relative to actor, while activities in orbitofrontal cortex (OFC) were greater for self than other only when the evaluation target played the role of recipient. These results showed that the actor-recipient role affected neural responses to self in emotional situations, especially when a recipient role was played in negative situations.
Gender-Dependent Association of FTO Polymorphisms with Body Mass Index in Mexicans

To evaluate the associations between six single-nucleotide polymorphisms (SNPs) in intron 1 of FTO and body mass index (BMI), a case-control association study of 2314 unrelated Mexican-Mestizo adult subjects was performed. The association between each SNP and BMI was tested using logistic and linear regression adjusted for age, gender, and ancestry and assuming additive, recessive, and dominant effects of the minor allele. Association analysis after BMI stratification showed that all five FTO SNPs (rs1121980, rs17817449, rs3751812, rs9930506, and rs17817449), were significantly associated with obesity class II/III under an additive model (P<0.05). Interestingly, we also documented a genetic model-dependent influence of gender on the effect of FTO variants on increased BMI. Two SNPs were specifically associated in males under a dominant model, while the remainder were associated with females under additive and recessive models (P<0.05). The SNP rs9930506 showed the highest increased in obesity risk in females (odds ratio = 4.4). Linear regression using BMI as a continuous trait also revealed differential FTO SNP contributions. Homozygous individuals for the risk alleles of rs17817449, rs3751812, and rs9930506 were on average 2.18 kg/m2 heavier than homozygous for the wild-type alleles; rs1121980 and rs8044769 showed significant but less-strong effects on BMI (1.54 kg/m2 and 0.9 kg/m2, respectively). Remarkably, rs9930506 also exhibited positive interactions with age and BMI in a gender-dependent manner. Women carrying the minor allele of this variant have a significant increase in BMI by year (0.42 kg/m2, P = 1.17 x 10−10). Linear regression haplotype analysis under an additive model, confirmed that the TGTGC haplotype harboring all five minor alleles, increased the BMI of carriers by 2.36 kg/m2 (P = 1.15 x 10−5). Our data suggest that FTO SNPs make differential contributions to obesity risk and support the hypothesis that gender differences in the mechanisms involving these variants may contribute to disease development.
The emotional attentional blink: what we know so far

The emotional attentional blink (EAB), also known as emotion-induced blindness, refers to a phenomenon in which the brief appearance of a task-irrelevant, emotionally arousing image captures attention to such an extent that individuals cannot detect target stimuli for several hundred ms after the emotional stimulus. The EAB allows for mental chronometry of stimulus-driven attention and the time needed to disengage and refocus goal-directed attention. In this review, we discuss current evidence for the mechanisms through which the EAB occurs. Although the EAB shares some similarities to both surprise-induced blindness (SiB) and other paradigms for assessing emotion-attention interactions, it possesses features that are distinct from these paradigms, and thus appears to provide a unique measure of the influence of emotion on stimulus-driven attention. The neural substrates of the EAB are not completely understood, but neuroimaging and neuropsychological data suggest some possible neural mechanisms underlying the phenomenon. The importance of understanding the EAB is highlighted by recent evidence indicating that EAB tasks can detect altered sensitivity to disorder relevant stimuli in psychiatric conditions such as post-traumatic stress disorder (PTSD).
The Photostabilizing Effect of Grape Seed Extract on Three Common Sunscreen Absorbers

The photostabilizing ability of grape seed extract on three common sunscreen absorbers, 2‐ethylhexyl‐p‐methoxycinnamate (EHMC), benzophenone‐3 (BP3) and tert‐butylmethoxy dibenzoylmethane (BMDBM), was investigated. Samples were exposed to simulated solar radiation and monitored by spectrophotometric and chromatographic methods. The chemical composition of the grape seed extract was determined by GC‐MS and HPLC‐MS, and the major secondary metabolites were found to be epicatechin and catechin. Exposure of the extract to UV radiation increased the UV absorption capacity of the extract. All sunscreens showed an improved photostability in the extract. The inherent photo‐instability of BMDBM when exposed to UV radiation was almost eliminated in the presence of grape seed extract. A mixture of all three sunscreens in the extract showed very high photostability and a red shift covering the entire UVB and UVA regions, thereby improving the broad‐spectrum protection. The incorporation of grape seed extract in sunscreen and other cosmetic formulations for topical application boosts photoprotection by stabilizing the UV filters and enhancing broad‐spectrum coverage. This in turn helps in reducing the amounts of absorbers and other additives incorporated in a sunscreen product and consequently lowers the risk of an unprecedented buildup of photoproducts whose toxicities are currently unknown.
Activation of Exchange Protein Directly Activated by Cyclic Adenosine Monophosphate and Protein Kinase A Regulate Common and Distinct Steps in Promoting Plasma Membrane Exocytic and Granule-to-Granule Fusions in Rat Islet &bgr; Cells

Objectives: Using FM1-43 epifluorescence imaging and electron microscopy, we recently reported that glucagon-like peptide (GLP-1)-mediated cyclic adenosine monophosphate (cAMP) potentiation of insulin secretion markedly promotes the number of plasma membrane (PM) exocytic sites and insulin secretory granule (SG)-to-granule fusions underlying compound and sequential exocytosis. Methods: Here, we used FM1-43 imaging to dissect the distinct contributions of putative GLP-1/cAMP activated substrates-exchange protein directly activated by cAMP (EPAC) and protein kinase A (PKA)-in mediating these exocytic events. Results: Like GLP-1, cAMP activation by forskolin increased the number of PM exocytic sites (2.3-fold), which were mainly of the robust-sustained (55.8%) and stepwise-multiphasic (37.7%) patterns corresponding to compound and sequential SG-SG exocytosis, respectively, with few monophasic hotspots (6.5%) corresponding to single-granule exocytosis. Direct activation of EPAC by 8-(4-chloro-phenylthio)-2′-O-methyladenosine-3′,5′-cAMP also increased the number of exocytic sites, but which were mainly multiphasic (60%) and monophasic (40%) hotspots. Protein kinase A inhibition by H89 blocked forskolin-evoked robust-sustained hotspots, while retaining multiphasic (47%) and monophasic (53%) hotspots. Consistently, PKA activation (N6-benzoyladenosine-3′,5′-cAMP) evoked only multiphasic (60%) and monophasic (40%) hotspots. These results suggested that PKA activation is required but alone is insufficient to promote compound SG-SG fusions. 8-(4-Chloro-phenylthio)-2′-O-methyladenosine-3′,5′-cAMP plus N6- benzoyladenosine-3′,5′-cAMP stimulation completely reconstituted the effects of forskolin, including increasing the number of exocytic sites, with a similar pattern of robust-sustained (42.6%) and stepwise (39.6%) hotspots and few monophasic (17.8%) hotspots. Conclusions: The EPAC and PKA modulate both distinct and common exocytic steps to potentiate insulin exocytosis where (a) EPAC activation mobilizes SGs to fuse at the PM, thereby increasing number of PM exocytic sites; and (b) PKA and EPAC activation synergistically modulate SG-SG fusions underlying compound and sequential exocytoses.Abbreviations: CICR - calcium-induced calcium release, 8-CPT-2′-O-Me-cAMP - 8-(4-chloro-phenylthio)-2′-O-methyladenosine-3′,5′-cyclic monophosphate, EPAC - exchange protein directly activated by cAMP, IBMX - 3-isobutyl-1-methylxanthine, GLP-1 - glucagon-like peptide 1, N6-Bnz-cAMP - N6-benzoyladenosine-3′,5′-cyclic monophosphate, PKA - protein kinase A, PM - plasma membrane, RRP - readily releasable pool, SG - secretory granule, SUR-1 - sulfonylurea receptor 1
Transgenerational epigenetic imprints on mate preference

Environmental contamination by endocrine-disrupting chemicals (EDC) can have epigenetic effects (by DNA methylation) on the germ line and promote disease across subsequent generations. In natural populations, both sexes may encounter affected as well as unaffected individuals during the breeding season, and any diminution in attractiveness could compromise reproductive success. Here we examine mate preference in male and female rats whose progenitors had been treated with the antiandrogenic fungicide vinclozolin. This effect is sex-specific, and we demonstrate that females three generations removed from the exposure discriminate and prefer males who do not have a history of exposure, whereas similarly epigenetically imprinted males do not exhibit such a preference. The observations suggest that the consequences of EDCs are not just transgenerational but can be “transpopulational”, because in many mammalian species, males are the dispersing sex. This result indicates that epigenetic transgenerational inheritance of EDC action represents an unappreciated force in sexual selection. Our observations provide direct experimental evidence for a role of epigenetics as a determinant factor in evolution.