Miracle-dz/UniFAR-FTUs huggingface dataset:
Continuous quantitative measurement of the main bronchial dimensions and lung density in the lateral position by four-dimensional dynamic-ventilation CT in smokers and COPD patients

Purpose: The purpose of this study was to measure changes in lung density and airway dimension in smokers in the lateral position using four-dimensional dynamic-ventilation computed tomography (CT) during free breathing and to evaluate their correlations with spirometric values. Materials and methods: Preoperative pleural adhesion assessments included dynamic-ventilation CT of 42 smokers (including 22 patients with COPD) in the lateral position, with the unoperated lung beneath (dependent lung). The scanned lungs’ mean lung density (MLD) and the bilateral main bronchi’s luminal areas (Ai) were measured automatically (13–18 continuous image frames, 0.35 seconds/frame). Calculations included cross-correlation coefficients (CCCs) between the MLD and Ai time curves, and correlations between the quantitative measurements and spirometric values were evaluated by using Spearman’s rank coefficient. Results: The Δ MLD 1.05 (from the peak inspiration frame to the third expiratory frame, 1.05 seconds later) in the nondependent lung negatively correlated with FEV 1 /FVC ( r =- 0.417, P , 0.01), suggesting that large expiratory movement of the nondependent lung would compensate limited expiratory movement of the dependent lung due to COPD. The Δ Ai 1.05 negatively correlated with the FEV 1 /FVC predicted in both the lungs ( r =- 0.465 and - 0.311, P , 0.05), suggesting that early expiratory collapses of the main bronchi indicate severe airflow limitation. The CCC correlated with FEV 1 /FVC in the dependent lung ( r =- 0.474, P , 0.01), suggesting that reduced synchrony between the proximal airway and lung occurs in patients with severe airflow limitation. Conclusion: In COPD patients, in the lateral position, the following abnormal dynamic-ventilation CT findings are associated with airflow limitation: enhanced complementary ventilation in the nondependent lung, early expiratory airway collapses, and reduced synchrony between airway and lung movements in the dependent lung. ( MlD Ai in the left nondependent (cross-correlation 0.14) ( ). in the main bronchial ai in the left nondependent lung ( than in the right dependent lung ( A ). The nondependent/dependent ratio in the Δ MlD 1.05 value was 0.264.
Genetic ablation of Cav1 differentially affects melanoma tumor growth and metastasis in mice: role of Cav1 in Shh heterotypic signaling and transendothelial migration

Recommended Citation Capozza, Franco; Trimmer, Casey; Castello-Cros, Remedios; Katiyar, Sanjay; Whitaker-Menezes, Diana; Follenzi, Antonia; Crosariol, Marco; Llaverias, Gemma; Sotgia, Federica; Pestell, Richard G; and Lisanti, Michael P, "Genetic ablation of Cav1 differentially affects melanoma tumor growth and metastasis in mice: role of Cav1 in Shh heterotypic signaling and transendothelial migration. " (2012). Department of Cancer Biology Faculty Papers. Paper 29. https://jdc.jefferson. edu/cbfp/29
Comparative analysis of active and passive portfolio management: A theoretical approach Analyse comparative de la gestion active et passive des portefeuilles : Une approche théorique

: The crises that the world has experienced in the last few years are deeply changing the structure of the world economy and therefore of finance. Human being is probably at the end of 40 years of big deflation and may be at the beginning of a great reflation. This evolution will strongly impact the winning investment strategies, and will push investors to experiment with other methods in order to preserve their income and minimize risks. To achieve this, they must implement effective portfolio management by deploying tools and rigorous processes to manage priorities. Portfolio management can be achieved through either active or passive management. Active management aims to outperform the reference market of the managed portfolio. The manager, using various analytical tools, will select in a discretionary way the products, securities or sectors most likely to grow faster than the market. Conversely, passive or index management aims to faithfully replicate the performance of a benchmark market. There are several reasons why investors may choose between the two methods. Using a traditional literature review, this paper aims to outline the characteristics of each form of portfolio management by highlighting the key differences between active and passive management. This paper also emphasizes that personal preferences, investment objectives and risk tolerance play a crucial role in this decision. The main lessons of this article are that active management has the ability to provide higher returns, but is also accompanied by high fees and greater uncertainties regarding future performance. Passive management, by contrast, offers a more cost-effective approach, but can limit the opportunities for outperformance.
A causal modelling framework for reference-based imputation and tipping point analysis

We consider estimating the "de facto" or effectiveness estimand in a randomised placebo-controlled or standard-of-care-controlled drug trial with quantitative outcome, where participants who discontinue an investigational treatment are not followed up thereafter. Carpenter et al (2013) proposed reference-based imputation methods which use a reference arm to inform the distribution of post-discontinuation outcomes and hence to inform an imputation model. However, the reference-based imputation methods were not formally justified. We present a causal model which makes an explicit assumption in a potential outcomes framework about the maintained causal effect of treatment after discontinuation. We show that the "jump to reference", "copy reference" and "copy increments in reference" reference-based imputation methods, with the control arm as the reference arm, are special cases of the causal model with specific assumptions about the causal treatment effect. Results from simulation studies are presented. We also show that the causal model provides a flexible and transparent framework for a tipping point sensitivity analysis in which we vary the assumptions made about the causal effect of discontinued treatment. We illustrate the approach with data from two longitudinal clinical trials.
Personal Assessments of Minimum Income and Expenses: What Do They Tell Us about 'Minimum Living' Thresholds and Equivalence Scales?

Subjective minimum income (MIQ) and minimum spending (MSQ) are the study focus. Basic Needs Module (1995) data from the U.S. Survey of Income and Program Participation are analyzed. A regression intersection approach is used to estimate household thresholds. MIQ thresholds are higher than MSQ thresholds. Both are higher than U.S. official poverty thresholds, and thresholds based on a National Academy of Sciences (NAS) methodology. Subjective threshold based equivalence scales imply greater economies of scale than those in the other two measures but are similar to behavioral scales. This finding suggests that families make trade-offs to meet their minimum needs.
University of Electroporation and microinjection successfully deliver single-stranded and duplex DNA into live cells as detected by FRET measurements

Fo¨rster resonance energy transfer (FRET) technology relies on the close proximity of two compatible fluorophores for energy transfer. Tagged (Cy3 and Cy5) complementary DNA strands forming a stable duplex and a doubly-tagged single strand were shown to demonstrate FRET outside of a cellular environment. FRET was also observed after transfecting these DNA strands into fixed and live cells using methods such as microinjection and electroporation, but not when using lipid based transfection reagents, unless in the presence of the endosomal acidification inhibitor bafilomycin. Avoiding the endocytosis pathway is essential for efficient delivery of intact DNA probes into cells. no role in study data and to
A note on p-elasticae and the generalized EMP equation

A correspondence is shown to exist between p-elastic curves (a generalization of the classical Euler elastica) of the Euclidean and Minkowski 3-spaces and a certain family of generalized Ermakov-Milne-Pinney (EMP) equations. Actually, combining the Euler-Lagrange equations of the p-elastica variational problem with the Frenet formulae for regular curves, a relation between the p-elastica curvature and some generalized EMP equations is obtained. As a consequence, since p-elasticae are totally determined by their curvature, they can be seen as geometric solutions of this class of generalized EMP equations and can be used as an alternative route for obtaining exact solutions of them, as illustrated by a couple of examples. As another consequence, ﬁrst integrals of these nonlinear equations are derived.
Groupware adoption the role of groupware potency and social influences

Disclaimer This document contains a student thesis (bachelor's or master's), as authored by a student at Eindhoven University of Technology. Student theses are made available in the TU/e repository upon obtaining the required degree. The grade received is not published on the document as presented in the repository. The required complexity or quality of research of student theses may vary by program, and the required minimum study period may vary in duration.
GLOBAL TUBERCULOSIS CONTROL: LESSONS LEARNED FROM NEW YORK AND OTHER PLACES

Tuberculosis (TB) maintains it grim historical notoriety as one of the leading infectious causes of death worldwide. Ironically, it is preventable and, in most cases, treatable. Infection-control precautions can help reduce the risk of TB transmission. Medical treatment of persons with latent TB infection can prevent the subsequent development of active TB disease. TB disease can usually be cured with anti-TB drugs taken exactly as prescribed. Even persons with drugresistant strains can often be cured by alternative regimens of medications.
DOES ESG PERFORMANCE INFLUENCE A FIRM ’S PROBABILITY OF DEFAULT?

This thesis investigates the effects of engagement in ESG (environmental, social, governance) activities on the probability of default by using data from 423 non-financial public European firms between 2000 and 2019. The probability of default proxy is calculated by using the structural model of Merton’s distance -to-default and the measures for ESG Score and ESG Controversies score are obtained from the Refinitiv database. ESG Score is calculated by Refinitiv based on the data provided by each company and compared to peers, while ESG Controversies score is based on controversial ESG events ’ information collected by Refinitiv from public media. The statistically significant results support one of the hypotheses that firms with higher ESG scores experience a higher probability of default, while either unobserved firm-related or year-related variables are being fixed. There was no significant evidence found to support the opposite hypothesis that higher ESG scores are negatively related to the probability of default. Another hypothesis that firms with higher ESG Controversies scores have a lower probability of default is also supported by the results of this thesis.
Speech planning as an index of speech motor control maturity

This paper investigates speech motor control maturity in 4-year-old Canadian French children. Acoustic and ultrasound data recorded from four children, and for comparison, from four adults, are presented and analyzed. Maturity of speech motor control is assessed by measuring two characteristics: token-to-token variability of isolated vowels, as a measure of motor control accuracy, and extra-syllabic anticipatory coarticulation within V1-C-V2 sequences. In line with theories of optimal motor control, anticipatory coarticulation is assumed to be based on the use of internal models of the speech apparatus and its efficiency is considered to reflect the maturity of these representations. In agreement with former studies, token-to-token variability is larger in children than in adults. An anticipation of V2 in V1 was found in all adults but in none of the children studied so far. These results indicate that children's speech motor control is immature from two perspectives: insufficiently accurate motor control patterns for vowel production, and inability to anticipate forthcoming gestures. Both aspects are discussed and interpreted in the context of the immaturity of the internal representations of the speech motor apparatus in 4-year-old children.
FT-IR coupled secondary metabolites profiling and biological activities of Neolamarckia cadamba leaves

: Neolamarckia cadamba is a pharmacologically signiﬁcant tropical tree, exploited for various biological studies due to its rich secondary metabolites. In the present investigation, comparison of pharmacological and biological studies of ﬁve diﬀerent extracts of Neolamarckia cadamba leaves have been carried out. This is the ﬁrst report of phytochemical studies of ﬁve diﬀerent extracts, coupled with FT-IR spectroscopy. Methanol extract (NCLE-D) was found to be rich in secondary metabolites. This extract also showed higher phenolic (279.023 GAE/g extract) and ﬂavonoid (1067.48 QE/g extract) contents. Ethyl acetate extract (NCLE-C) and NCLE-D showed signiﬁcant free radical scavenging activity with IC 50 15.17 (cid:22) g/mL and 16.12 (cid:22) g/mL respectively compared to ascorbic acid (positive control) with IC 50 5.22 (cid:22) g/mL. NCLE-C
Controlling the work hardening of martensite to increase the strength/ductility balance in quenched and partitioned steels

The roleof retained austenite on tensilebehavior inquenched and partitioned (Q&P) steelshas beenstudiedex- tensively,butthedeformationbehaviorofmartensite,whichcomprisesthemajorityofQ&Pmicrostructures,has received less attention. In this investigation, martensite properties were varied through heat treatment in a low carbon Q&P steel consisting of retained austenite and martensite. Additional conditions were produced by reheating the Q&P steel to 450 °C for 30 min or to 700 °C followed immediately by quenching. The reheated mi- crostructures contained similar fractions of retained austenite as the non-reheated Q&P microstructures, but reheating tempered the martensite, thereby decreasing martensite dislocation density. The reheated conditions had a lower yield stress and initial work hardening rate than the non-reheated Q&P condition. However, the reheatedconditionshadagreaterworkhardeningrateatlargerstrainsandgreateruniformstrainduetolesssta- ble retained austenite. Furthermore, the tensile strength of the condition reheated to 450 °C was nearly equal to the non-reheated condition. In addition to retained austenite to martensite transformation, the early stage work hardeningrateofmartensiteiscriticaltoductilityandisdependentonmartensitedislocationdensity,whichcan be decreased through tempering. The (http://creativecommons.org/licenses/by-nc-nd/4.0/).
can eye-tracking technology improve situational awareness in paramedic clinical education?

: Human factors play a significant part in clinical error. Situational awareness (SA) means being aware of one’s surroundings, comprehending the present situation, and being able to predict outcomes. It is a key human skill that, when properly applied, is associated with reducing medical error: eye-tracking technology can be used to provide an objective and qualitative measure of the initial perception component of SA. Feedback from eye-tracking technology can be used to improve the understanding and teaching of SA in clinical contexts, and consequently, has potential for reducing clinician error and the concomitant adverse events.
Empirical Methods for Predicting Eutrophication in Impoundments. Report 1. Phase I. Data Base Development.

Abstract : Simple formulations relating nutrient loadings and certain morphologic characteristics to trophic state have provided lake managers one means for describing lake problems and predicting the potential impact of management decisions. While the general utility of such models has been demonstrated for natural lakes, the applicability of models for reservoirs has not received adequate evaluation. This work unit is concerned with the evaluation and possible modification of existing models for predicting water quality and eutrophication potential. This report documents the establishment of a computerized data base containing water quality, hydrologic, and morphometric information for 299 reservoirs operated by the Army Corps of Engineers (CE). Sources of information included STORET (including the National Eutrophication Survey data), Department of Agriculture sedimentation survey data sheets, project design memoranda and CE District and Division data files. Supplemental sources included maps, project brochures, and reports. Programming for data manipulation and analysis is in the PL/I and FORTRAN IV languages. BMDP and SAS programs were employed during preliminary analysis. The data base presently contains over 2.5 million water quality observations taken at 4451 stations located in or around 271 CE reservoirs. Methods for estimating volume and ara variations with elevation, required for volume-averaging of water quality data and for calculating material loadings, were developed. Preliminary analyses have also been performed to assess the importance of spatial and temporal variability to the computation of representative water quality values.
Seismic Damage States and Response Parameters for Bridge Columns

Detailed data from 30 bridge column models, mostly tested on shake tables, were evaluated to determine the correlation between the apparent damage and internal and external seismic response parameters. The majority of the columns were of circular cross section. The columns were divided into five categories based on seismic design, shear demand, and ground motion type. Five distinct damage states were proposed based on the apparent damage. Six response parameters were also defined in terms of drift, frequency, strains, yielding, and ultimate displacements. The correlation between damage states and the response parameters were determined for each column category. The results demonstrate a general trend relating damage states to response parameters. Using the observed damage and the data presented in this article it was shown that an estimate of a non-dimensionalized push over curve may be made.
Journal of Biotechnology Research Center Vol.7 No.3

The aim of our study was to determine micronucleus MN frequency and nuclear division index in peripheral blood lymphocytes of patients diagnosed with Acute Lymphoblastic Leukemia ALL, who had undergone chemotherapy. Patients were treated with nine of drugs, which included Vincristine , Methotrexate , Cytosar-U, Lasparaginase , Etoposide, , dexamethasone (Decadron) , Indoxan , Steroids. The study was carried out on fifty Iraqi patients (34 Male, 16 Female), aged 2-70 years with Acute Lymphoblastic Leukemia ALL. These samples included 20 pretreatment aged 7-70 years, 15 under treatment aged 2-57years and 15 relapsed aged 9-40 years, compared with a sample consisted of 50 apparently healthy normal individuals collected randomly from population living in Baghdad aged 3-75 years. Results of the of MN in the human lymphocyte observed a significant increase p<0.05 in the males and females of human peripheral blood lymphocytes of patients with Acute Lymphoblastic Leukemia, before and after the chemotherapy as compared with the control. While, a significant decrease P> 0.05 in nucleic division index NDI was observed in the human peripheral blood lymphocytes of Acute Lymphoblastic Leukemia Patients (males and females), before and after the chemotherapy as compared with the control. In addition, the results of MN and NDI were compared in the genders of the groups studied. In conclusion, the results indicated that there is a possibility of using the changes in the mean of MN frequency and NDI as biomarkers for the assessment of DNA damage in the human peripheral blood lymphocytes of patients with Acute Lymphoblastic Leukemia ALL before and after the chemotherapy treatment and the increase frequencies of MN in ALL patients indicate the effect of antileukemic agents in inducing somatic genetic damage.
Quantifying informativeness of names in visual space

The human lexicon expresses a wide array of concepts with a limited set of words. Previous work has suggested that semantic categories are structured compactly to enable informative communication. Informativeness is typically quantiﬁed with respect to an entire semantic domain and not at the level of individual names. We develop a measure of name informativeness using an information-theoretic framework grounded in visual object representations derived from natural images. Our approach uses computer vision models to characterize in-formativeness of individual names with respect to large-scale data in a naturalistic setting. We show that our informativeness measure predicts degrees of speciﬁcity in lexical categories more precisely than alternative measures based on entropy and frequency. We also show that name informativeness jointly captures within-category similarity and distinctiveness across categories. Our analyses suggest how the variability of names from a broad part of the lexicon may be understood through the lens of information theory.
DDDT_A_207823 2997..3007

1Reproductive Medicine Centre, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, People’s Republic of China; 2Department of Orthopaedics and Traumatology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, People’s Republic of China; 3Central Laboratory, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, People’s Republic of China