Miracle-dz/UniFAR-FTUs huggingface dataset:
The molecular feature miner MolFea

Inductive databases are a new generation of databases, that are capable of dealing with data but also with patterns or regularities within the data. A user can generate, manipulate and search for patterns of interest using an inductive query language. Data mining then becomes an interactive querying process. The inductive database framework is especially interesting for bioand chemoinformatics, because of the large and complex databases that exist in these domains, and the lack of methods to gain scientific knowledge from them. In this article we present an example for inductive databases: Molfea is the Molecular Feature Miner that mines for linear fragments in the 2D-structure of chemical compounds. In the methodological part we will explain the inner working of the Molfea algorithm, using a simple example. In the second part we will present applications to the NCI DTP AIDS Antiviral Screen database and several benchmark Structure-Activity Relationship problems in toxicology.
All you need is love: feminist pedagogy for empowerment and emotional labour in the academy

This paper critically examines the concept of empowerment and considers the contradictory role of feminist teachers and authority in dominant institutions of knowledge production. Questions are raised about the emotional labour required to sustain feminist pedagogy for empowerment in the academy. Issues of student resistance, group dynamics, difference and diversity in women‐only groups are interrogated using the theoretical frameworks of critical and feminist pedagogy and postmodernism. The paper draws illustratively on interviews with feminist academics who were asked how they applied feminism to their pedagogy/ teaching methodologies, and students who identified as feminists were asked for their views on styles of classroom interaction.
Optimization of limiting reactors design for DC fault protection of multi-terminal HVDC networks

In multi-terminal dc networks (MTdc) reactors are required to limit the rate of rise and the peak values of the fast developing currents in case of a dc fault. In this way, dc breakers have more time to isolate a fault and the system can restore its post-fault operation. This paper proposes a methodology to optimize the design of limiting reactors used for the protection of voltage-source converter (VSC) based MTdc networks. The limiting reactors were optimized using the covariance matrix adaptation evolution strategy (CMA-ES) optimization algorithm with two design objectives: first, the minimization of the reactor inductance value at the output of each VSC station to achieve N-1 security and second, the minimization of the reactors cost and mass and the peak dc fault current. Following the methodology steps, the effect of the dc fault location and the pre-fault power level of the converters on the dc fault network response are investigated in a four-terminal radially-connected grid. It resulted that the VSC stations controlling the dc voltage of the MTdc network are the first to respond to a dc fault and thus, limiting reactors higher than 97 mH are required in their dc output, in combination with dc breakers faster than 5 ms, to successfully protect the grid of the present case study.
Use and effects of cannabinoids in military veterans with posttraumatic stress disorder.

PURPOSE Published evidence regarding the use of cannabis and cannabis derivatives by military veterans with posttraumatic stress disorder (PTSD) is reviewed. SUMMARY When inhaled or delivered orally or transdermally, cannabinoids (the psychoactive components of unrefined marijuana and various derivative products) activate endogenous cannabinoid receptors, modulating neurotransmitter release and producing a wide range of central nervous system effects, including increased pleasure and alteration of memory processes. Those effects provide a pharmacologic rationale for the use of cannabinoids to manage the three core PTSD symptom clusters: reexperiencing, avoidance and numbing, and hyperarousal. A literature search identified 11 articles pertaining to cannabis use by military veterans who met standard diagnostic criteria for PTSD. Cross-sectional studies have found a direct correlation between more severe PTSD symptomatology and increased motivation to use cannabis for coping purposes, especially among patients with difficulties in emotional regulation or stress tolerance. Data from 4 small studies suggested that cannabinoid use was associated with global improvements in PTSD symptoms or amelioration of specific PTSD symptoms such as insomnia and nightmares. Large well-designed controlled trials are needed in order to better delineate the potential role of cannabinoids as an adjunct or alternative to conventional approaches to PTSD management. CONCLUSION While further research into cannabinoid treatment effects on PTSD symptoms is required, the evaluated evidence indicates that substantial numbers of military veterans with PTSD use cannabis or derivative products to control PTSD symptoms, with some patients reporting benefits in terms of reduced anxiety and insomnia and improved coping ability.
An Integrative Review of Computer-based Simulation in the Education Process

The purpose of this study was to review quantitative studies related to computer-based simulation and healthcare education and determine the effect of simulation on education and learning. A total of 513 references were retrieved, but only 9 quantitative studies met the inclusion criteria. To synthesize the data, the mean scores and standard deviations of the studies were used to determine the effect size, the d index, and the direction of the effect. This review indicates that 75% of the studies showed positive effects of simulation on skill and/or knowledge acquisition. The potential of computer-based simulation as an education augmentation is enormous, but research is needed to determine effective and successful uses of high-fidelity simulations for nursing education.
Examining the Impact of Peer Group Selection on Self-Reported Delinquency

Research has yet to discount all sources of confounding in the relationship between an individual’s delinquent behavior and that of his or her peers. One approach is to control for an active gene–environment correlation (rGE). Active rGE occurs when one selects into an environment based on genetic propensities. The current study utilizes twin data from the National Longitudinal Study of Adolescent Health to examine the impact of a direct measure of peer delinquency on self-reported delinquency while controlling for active rGE. The final analytic sample ranged between 456 and 524 dizygotic and 286 and 350 monozygotic twins, depending on the measures being analyzed. Using an augmented version of the DeFries–Fulker model, results revealed the peer effect was no longer statistically significant once genetic confounding (active rGE) was controlled. These findings support selection arguments and run counter to learning theory explanations.
Reading mechanisms and the organisation of the lexicon: Evidence from acquired dyslexia

The study of patients with acquired reading disorders has contributed significantly to the formulation and development of models of the normal reading process (e.g., Coltheart, 1981; Patterson, 1981; Saffran, in press; Shallice, 1981; Martin & Caramazza, in press). Various forms of acquired dyslexia have been described providing a rich source of constraints on the structure and organisation of the lexicon and of the cognitive mechanisms implicated in the reading process. The explanation within a single, coherent framework of such diverse symptoms as the production of semantic (e.g., reading “table” as “chair”) or morphological (e.g., reading “walked” as “walking”) paralexias or the ability to read some types of words (e.g., nouns or regularly spelled words) but not other types (e.g., function words or irregularly spelled words), and so forth, severely reduces our options in formulating a model of normal reading which when appropriately lesioned produces the various symptoms and symptom complexes observed.
Fetal exposure to nonsteroidal anti-inflammatory drugs and spontaneous abortions

Background: Spontaneous abortion is the most common complication of pregnancy. Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used during pregnancy. Published data are inconsistent regarding the risk of spontaneous abortion following exposure to NSAIDs. Methods: We performed a historical cohort study involving all women who conceived between January 2003 and December 2009 and who were admitted for delivery or spontaneous abortion at Soroka Medical Center, Clalit Health Services, Israel. A computerized database of medication dispensation was linked with 2 computerized databases containing information on births and spontaneous abortions. We constructed time-varying Cox regression models and adjusted for maternal age, diabetes mellitus, hypothyroidism, obesity, hypercoagulation or inflammatory conditions, recurrent miscarriage, in vitro fertilization of the current pregnancy, intrauterine contraceptive device, ethnic background, tobacco use and year of admission. Results: The cohort included 65 457 women who conceived during the study period; of these, 58 949 (90.1%) were admitted for a birth and 6508 (9.9%) for spontaneous abortion. A total of 4495 (6.9%) pregnant women were exposed to NSAIDs during the study period. Exposure to NSAIDs was not an independent risk factor for spontaneous abortion (nonselective cyclooxygenase [COX] inhibitors: adjusted hazard ratio [HR] 1.10, 95% confidence interval [CI] 0.99–1.22; selective COX-2 inhibitors: adjusted HR 1.43, 95% CI 0.79–2.59). There was no increased risk for specific NSAID drugs, except for a significantly increased risk with exposure to indomethacin (adjusted HR 2.8, 95% CI 1.70–4.69). We found no dose–response effect. Interpretation: We found no increased risk of spontaneous abortion following exposure to NSAIDs. Further research is needed to assess the risk following exposure to selective COX-2 inhibitors.
Critical role of endothelial P-selectin glycoprotein ligand 1 in chronic murine ileitis

L-selectin ligands might be relevant for inflammatory cell trafficking into the small intestine in a spontaneous model of chronic ileitis (i.e., SAMP1/YitFc mice). Immunoblockade of peripheral node addressin or mucosal addressin cell adhesion molecule 1 failed to ameliorate ileitis, whereas P-selectin glycoprotein ligand 1 (PSGL-1) neutralization attenuated both the adoptively transferred and spontaneous disease. PSGL-1 was detected in venules of mesenteric lymph node and small intestine by immunohistochemistry and confirmed by real-time reverse transcription polymerase chain reaction and flow cytometry. In addition, reconstitution of wild-type mice with PSGL-1−/− bone marrow demonstrated that PSGL-1 messenger RNA and PSGL-1 protein expression remained on endothelium, localized within mesenteric lymph node and small intestine. Endothelial PSGL-1 bound P-selectin–IgG and its blockade or genetic deletion altered the recruitment of lymphocytes to the small intestine, as revealed by intravital microscopy and homing studies. Endothelial expression of PSGL-1 adds a new dimension to the various cellular interactions involved in small intestinal recruitment. Thus, the multiple roles of PSGL-1 may explain why targeting this single adhesion molecule results in attenuation of chronic murine ileitis, a disease previously resistant to antiadhesion molecule strategies.
The social semantic desktop: A new paradigm towards deploying the semantic Web on the desktop

This chapter introduces the general vision of the Social Semantic Desktop (SSD) and details it in the context of the NEPOMUK project. It outlines the typical SSD requirements and functionalities that were identified from real world scenarios. In addition, it provides the design of the standard SSD architecture together with the ontology pyramid developed to support it. Finally, the chapter gives an overview of some of the technical challenges that arise from the actual development process of the SSD.
Does the GI Bill Support Educational Attainment for Veterans with Disabilities? Implications for Current Veterans in Resuming Civilian Life

A secondary data analysis of the 2001 National Survey of Veterans (NSV) for 2075 Gulf War-era veterans was conducted to investigate whether the GI Bill (the Servicemen’s Readjustment Act of 1944, most recent provisions of which have been entitled the Montgomery GI Bill and the Post 9/11 GI Bill), considered as a social welfare policy, demonstrated protective effects for veterans with disabilities in terms of successful re-entry and sustained enrollment in higher education. Regression analyses to test the mediation effects of use of the GI Bill, use of non-Veterans’ Administration (VA) financial aid, and use of VA health services sug gested mediation effects; however, post hoc testing did not yield significant results. Analysis of this and an alternative multiple mediator model using bootstrapping strategies for assessing indirect effects suggested that total and non-labor income and social support, not the GI Bill, mediate the effects of disability on educational attainment among this population. Implications for social welfare policies and programs to support this population’s access to and success in post-secondary institutions are highlighted.
Screening for Alzheimer’s Disease with the Short Cognitive Evaluation Battery

Because Alzheimer’s disease (AD) tends to be underdiagnosed, there is an increasing need for accurate neuropsychological screening tools that are easy to administer by general practitioners or specialists. The aim of the present study was to validate, in French, a sensitive and specific screening battery designed to improve the discrimination between patients with AD, patients with depression and healthy elderly subjects. The Short Cognitive Evaluation Battery (SCEB) consists of 4 brief tests: temporal orientation, 5-word test, clock-drawing test and a semantic verbal fluency task. The SCEB was administered to 123 ambulatory subjects (mean age 76.4±2.3 years): 49 patients with mild AD, 27 patients with depressive symptoms and 47 healthy elderly subjects. The mean time for administration of the test was 11.2 min in the AD group, 8.2 min in the depressive group and 7.2 min in the control group (p < 0.001). Multivariate analysis showed that, compared with controls, patients with mild AD were significantly impaired for all four tests. Response operating characteristics analysis of the SCEB showed: 93.8% sensitivity and 85% specificity for discriminating AD from control patients, and 63% sensitivity and 96% specificity for discriminating AD from depressive patients. In summary, the SCEB appears to be a highly sensitive and specific tool for discriminating between patients with mild AD and healthy elderly individuals. Furthermore, in combination with clinical evaluation, the SCEB could improve the specificity of the difficult discrimination between mild AD and depression.
Faith-based schools in Australia: a fertile setting for research endeavour

Political, market and historical forces within Australia have produced a supportive environment for creating a new marketplace for schools, including those that are affiliated with a range of different faiths. Indeed, this sector has now become a significant feature of the Australian educational landscape. This article argues that the increasing significance of faith-based schools in combination with their complexity, distinctiveness and controversy makes them a particularly fertile setting for research endeavour; an endeavour which seems to have become an imperative, given that current understandings of these schools are heavily influenced by the media.
Increasing Children's Interest through Performance-Contingent Reward

It was hypothesized that rewards made contingent on performance quality would enhance intrinsic motivation, since this type of contingency would provide information about task competence. Children received rewards for successfully (performance-contingent) or simply (task-contingent) completing a series of maze puzzles under conditions that made the reward contingency more or less salient. Subsequent to this manipulation, children were given the opportunity to play with additional maze puzzles or alternative activities during a 5-minute free-choice session, in which they were observed unobtrusively. In general, performance-contingent rewards enhanced children's interest relative to task-contingent rewards and a no-reward control, and these effects were more pronounced when the contingencies were made salient. Sex differences emerged, indicating that performance-contingent rewards were more effective in enhancing the intrinsic motivation of boys. The pattern of data obtained suggests ways in which reward ca.
Exploiting Power-Area Tradeoffs in Behavioural Synthesis through clock and operations throughput selection

This paper describes a new dynamic-power aware high level synthesis (HLS) data path approach that considers the close interrelation between clock choice and operations throughput selection whilst attempting to minimize area, power, or a combination thereof. It is shown that the proposed approach with its compound cost function and its novel clock and operations throughput selection algorithm, obtains solutions with lower power and area than using previous relevant work (Raghunathan, 1997), Moreover, different power-area tradeoffs can be explored due to the appropriate choice of clock period and operations throughput using our novel approach.
The Relationship between Self-efficacy, Autonomy and Learners' English Achievement: A Study of Iranian Students of Medicine

The present study aimed to extend our knowledge by exploring predictive role of self-efficacy and autonomy in Medical learners' (EMP) language performances. Gender was another variable of interest in the study. Set out to explore, self-efficacy and autonomy scales besides English achievement test were administrated and analyzed. Results of statistic alanalysis of Pearson correlation denote that there is a strong relationship between students' self-efficacy beliefs and their language performances (r = .893). In fact, it demonstrates the contributing effect of efficacy beliefs in taking responsibility in learning which lead to learners' significant attainments in learning tasks. Statistical analysis of the data also revealed that there is a significant correlation between learners' autonomous beliefs and their general English performance (r = .845). It is implied that faith in capabilities and directing and controlling learning are necessities to enhance EMP learners' achievements. Furthermore, the results show no significant differences between learners' autonomy with regard to their gender (t = .43). The study has some pedagogical implications which will be discussed in the paper.
Religion and obsessive-compulsive disorder (OCD) among young Muslim women in Saudi Arabia

Fifteen young women suffering from OCD in Saudi Arabia were interviewed about their experience of the illness and the roles played by religion. Religion was not perceived as a cause of the illness, but the illness can show itself in religious symptoms – notably with respect to prayer, and in a phase in which the young women were very strict and literal-minded with themselves and their families, with respect to religious observance. Religious symptoms were reported as more upsetting than other symptoms – being seen as damaging to the sufferer's piety. Other facets of the importance of religion in the experience of OCD were shown in help-seeking, in choosing to go first to religious healers for treatment, and only when these were unsuccessful were mental health professionals consulted. At this point, it was very important that the professional should be seen as trustworthy, and the criterion of trustworthiness was religiosity, specifically the use of pious, Qura’anic quotations, and a covered face (for a woman)/long beard (for a man). The accounts of the roles of religion in the experiences of the young women interviewed suggest that religion is an arena – but not the sole arena – for the expression of OCD symptoms. Religion plays an important role in determining the acceptability of treatments and treatment providers.
Motion-pointing: target selection using elliptical motions

We present a novel method called motion-pointing for selecting a set of visual items such as push-buttons without actually pointing to them. Instead, each potential target displays a rhythmically animated point we call the driver. To select a specific item, the user only has to imitate the motion of its driver using the input device. Once the motion has been recognized by the system, the user can confirm the selection to trigger the action. We consider cyclic motions on an elliptic trajectory with a specific period, and study the most effective methods for real-time matching such a trajectory, as well as the range of parameters a human can reliably reproduce. We then show how to implement motion-pointing in real applications using an interaction technique we call move-and-stroke. Finally, we measure the throughput and error rate of move-and-stroke in a controlled experiment. We show that the selection time is linearly proportional to the number of input bits conveyed up to 6 bits, confirming that motion-pointing is a practical input method.
An Assessment of Meyer and Allen's (1991) Three-Component Model of Organizational Commitment and Turnover Intentions

Abstract Propositions about the relationship between Meyer and Allen's (1991) model of organizational commitment and turnover intentions were tested via field research. Specifically, we assessed concurrent and longitudinal effects of affective, continuance, and normative commitment on turnover intentions. We tested main and interaction effects and also assessed the effects of two continuance commitment sub-dimensions—CC-hisac and CC-loalt—on turnover intentions. Two studies were conducted to test these relationships. Data were collected from a sample of engineering personnel working at an aerospace firm, and from university students employed full time in a variety of organizations. The results revealed that, (1) contrary to expectations, the three components of commitment differed in the significance of their effects on turnover intentions, and (2) the CC subdimensions differed in their effects on turnover intentions. The discussion of these results focuses on their implications for theoretical and practical issues in commitment research.