Miracle-dz/UniFAR-FTUs huggingface dataset:
Episomal and Nonepisomal Herpesvirus DNA in Lymphoid Tumor Cell

Herpesviruses are able to persist for years or for life in certain cells of the host organism, for example, in neural tissue and cells of the lymphatic series. Little is known at the molecular level about the mode of herpesvirus persistence and the factors determining reactivation to secondary diseases, oncogenic transformation of appropriate target cells, elimination of virus-transformed cells by the immune system, and eventual outgrowth as a malignant tumor. The DNA of Epstein-Barr virus (EBV) is able to form circular molecules and to persist in human tumor tissues and lymphoblastoid tumor cell lines in the form of episomal viral genomes (Kaschka-Dierieh et al. 1976; Lindahl et al. 1976). Some viral DNA, however, was found consistently to band with host cell DNA upon consecutive density centrifugations in CsCI gradients (Adams et al. 1973; Adams 1979). This has led to the conclusi on that some EBV DNA is integrated into chromosomal DNA in transformed cells. There are, however, at least two problems with this interpretation. First, it is diffieult to rule out all artifactual explanations, and secondly, methylation of viral DNA could cause a density shift toward the density of cellular DNA. In an attempt to learn more about mechanisms of herpesvirus persistence and oncogenie transformation, we have concentrated our efforts on the highly oncogenie herpesviruses of New World primates, Herpesvirus saimiri (H. saimiri) and Herpesvirus ateles (H. ateles). A lytic system for growth and the peculiar genome structure of these virus es offer advantages in the biochemieal analyses of persisting viral DNA. B. Structure of Episomal DNA
Treatment Strategy for Different Risk Groups in Childhood Acute Lymphoblastic Leukemia : AReport From the BFM Study Group

Development of effective treatment programs for childhood acute lymphoblastie leukemia (ALL) has led to marked improvement of prognosis. The proportion of patients remaining in first remission for at least 5 years is generally estimated to be in the range of 50% once remission is achieved (Frei and Sallan 1978; Riehm etal.1980;Robisonetal.1980). Since remission rates have been shown to be 90%-95 % with currently used induction therapy, successful induction of remission is no longer an essential problem. Nevertheless, the quality of remission is apparently unsatisfactory in about one-half of the patients, eventually resulting in recurrence of the disease. Predictors of outcome have been defined and include white blood count (WBC), sex, thymic involvement, central nervous system disease at diagnosis, immunologie markers, unfavorable age, and blast cell morphology (Dow et al. 1977; Henze et al. 1979; Mathe et al. 1971; Sallan et al. 1978; Simone et al. 1975; Wagner and Baehner 1979; Working Party on leukemia in Childhood 1978); but attempts to adapt the therapeutic strategy to the presence of factors associated with a poor prognosis have not been able to enhance significantly therapeutie results. The approach of the BFM study group with the concept of intensive multidrug remission induction gives hope for an overall 75 % relapse-free survival in childhood ALL.
Kriging Interpolation Method for Estimation of Continuous Spatial Distribution of Precipitation in Cyprus

Aims: Development of a precipitation prediction model for Cyprus. Study Design: Precipitation data collected at 78 stations were used: data from 66 stations for model development and data from 12 stations for additional tests. Four topographic factors – altitude, slope, longitude, and latitude – were taken into account for model development. Place and Duration of Study: All variables were obtained from the observation archives of the Water Development Department of the Ministry of Agriculture, Natural Resources and Environment of Cyprus, between 1961 and 1990. Methodology: Multiple regression analysis, combined with residuals correction, was carried out to develop a precipitation prediction model. Results: The multiple regression model can explain 61.3% of the spatial variability of precipitation over the whole year, 57.5% of variability in the wet season (October–April), and 99.6% of variability in the dry season (May–September). Interpolation-based Research Article British Journal of Applied Science & Technology, 3(4): 1286-1300, 2013 1287 residuals correction improved the accuracy of our model (Adj_ R=65.1%, 62.6% and 99.7%, respectively). Conclusion: This approach, as presented in this paper, could potentially be applied to Cyprus’ climate research.
NAVIGATION ON A GREAT ELLIPSE

This paper presents contact formulae for the computation of the position, the distance, and the azimuth along a great ellipse. The proposed alternative formulae are to be primarily used for accurate sailing calculations on the ellipsoid in a GIS environment as in ECDIS and other ECS. Among the ECDIS Requirements is the need for a continuous system with a degree of accuracy consistent with the requirements of safe navigation. At present, this requirement is best fulfilled by the Global Positioning System (GPS). The GPS system is referenced to World Geodetic System 1984 (WGS 84) Datum. Using the ellipsoid model for the spherical model attains more accurate calculation of sailing on the Earth. Therefore, we construct a computational procedure for solving the length of the arc of a great ellipse, the waypoints and azimuths along a great ellipse. In this paper, we provide the straightforward formulae involving the great elliptic sailing based on two scenarios. The first scenario is that the departure point and the destination point are known. The second scenario is that the departure point and the initial azimuth are given.
Abstract: Geological setting, geochronological constraints and the nature of mineralization at the Mosquito Hill (Huxter Lane) gold deposit, central Newfoundland

The Mosquito Hill gold deposit in NTS map area 2D/5 of central Newfoundland was discovered in 1998, through prospecting and sampling of arsenopyrite-bearing quartz-feldspar porphyry float, in extensive till cover, immediately south of the Northwest Gander River. This geologically complex area contains from northwest–southeast: Precambrian to Cambrian rocks of the Spruce Brook Formation of the Ganderian Mount Cormack Subzone; the Cambrian ophiolitic Coy Pond Complex and, the Cambrian to Ordovician marine sedimentary and volcanic rocks of the Baie D’Espoir Group. Exploration work and ongoing geoscientific investigations indicate that Mosquito Hill mineralization is mainly hosted in non-foliated, quartzveined and sericite–arsenopyrite–pyrite-altered quartz-feldspar ± biotite ± hornblende-bearing, subvolcanic andesite–dacite porphyry (Mosquito Hill porphyry: MHP). The MHP ranges from fine to coarse grained and exhibits transitional contacts with compositionally similar crystal-lithic lapilli tuffs. The MHP is interleaved with affiliated volcaniclastic tuffs, epiclastic sandstones and grey and black graphitic shales and mudstones of the North Steady Pond Formation of the Baie d’Espoir Group, as well as a number of discrete mélange intervals. Mineralization consists of ≤15% disseminated euhedral arsenopyrite spatially associated with pyrite and abundant subhedral sericite grains and variable Fe-carbonate. Quartz veining appears to be slightly younger than alteration and highly anomalous gold is associated with abundant arsenopyrite rather than veining. Free gold has not been observed. The LAM-ICP-MS U–Pb zircon geochronology for two samples indicates that the MHP crystallized during the interval 508–469 Ma (494 ± 14 and 477 ± 8 Ma); the younger date overlapping, within error, the only other dated felsic volcanogenic rock (Twillick Brook Member, 468 ± 2 Ma), exposed in the easternmost Exploits Subzone. An intermediate dyke that crosscuts a portion of the mélange below mylonitized MHP yielded an age of 464 ± 7 Ma, placing a lower limit on the age of the volcanic rocks of the North Steady Pond Formation and demonstrating that some of the mélange must have formed in the Ordovician. Randomly oriented sericite, forming part of the alteration assemblage in the MHP yielded two identical Devonian Ar–Ar plateau ages of 406 ± 2 Ma. As these rocks preserve sub-greenschist-facies metamorphic mineral assemblages, the hydrothermal fluids generating the mineralization at Mosquito Hill must have immediately postdated regional widespread Silurian emplacement of bimodal granitoid intrusions and metamorphism and deformation in the Hermitage Flexure to the southwest.
A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Current guidelines recommend a period of moderate therapeutic hypothermia (TH) for comatose patients after cardiac arrest to improve clinical outcomes. However, in-vitro studies have reported platelet dysfunction, thrombocytopenia, and coagulopathy, results that might discourage clinicians from applying TH in clinical practice. We aimed to quantify the risks of hemorrhage observed in clinical studies. Medline and Embase were searched from inception to October 2015. Randomized controlled trials (RCTs) comparing patients undergoing TH with controls were selected, irrespective of the indications for TH. There were no restrictions for language, population, or publication year. Data on study characteristics, which included patients, details of intervention, and outcome measures, were extracted. Forty-three trials that included 7528 patients were identified from 2692 potentially relevant references. Any hemorrhage was designated as the primary outcome and was reported in 28 studies. The pooled results showed no significant increase in hemorrhage risk associated with TH (risk difference [RD] 0.005; 95% confidence interval [CI] 0.001– 0.011; I, 0%). Among secondary outcomes, patients undergoing TH were found to have increased risk of thrombocytopenia (RD 0.109; 95% CI 0.038–0.179; I 57.3%) and transfusion requirements (RD 0.021; 95% CI 0.003–0.040; I 0%). The meta-regression analysis indicated that prolonged duration of cooling may be associated with increased risk of D, Wei-Tien Chan d Wen-Jone Chen, MD, PhD Clinicians should cautiously assess each patient’s risk-benefit profile before applying TH. (Medicine 94(47):e2152) Abbreviations: CI = confidence interval, RCT = randomized controlled trial, RD = risk difference, TH = therapeutic
A systematic review and meta-analysis of randomized controlled trials

Objective: To evaluate the effectiveness of acupuncture in reproductive-age females with polycystic ovary syndrome (PCOS). Methods: We searched the Pubmed, Web of Science, Embase, Cochrane, China National Knowledge Infrastructure (CNKI), Wanfang Data, and Chongqing VIP databases for the relevant literature. The meta-analysis was performed with a random-effects model with RevMan 5.3. The primary outcomes of interest included the rate of live birth, pregnancy and ovulation, and the secondary outcomes included the recovery of menstrual period and hormone levels. Results were expressed as the relative risk (RR) for the discrete data and the mean difference (MD) for the continuous outcomes with a 95% confidence interval (CI). Results: Twenty two studies with 2315 participants were included in this systematic review and meta-analysis. A pooled analysis showed a recovery of the menstrual period (5 trials; 364 participants; SMD, 0.52; 95% CI [ 0.89, 0.14]; I=67%; P= .0007; low certainty) in the acupuncture group. Furthermore, there were significant decreases in the luteinizing hormone (LH) (13 trials; 917 participants; MD, 0.92; 95%CI [ 1.43, 0.41]; I=60%; P= .0004; very low certainty) and testosterone (13 trials; 923 participants; SMD, 0.46; 95% CI [ 0.73, 0.20]; I=75%; P= .0006; very low certainty) in the acupuncture group. No significant differences were observed in the rates of live birth, pregnancy, and ovulation, and no significant differences were observed in the LH/folliclestimulating hormone (FSH) ratio. Conclusions: There was insufficient evidence to support that acupuncture could promote live birth, pregnancy, and ovulation. However, acupuncture could promote the recovery of menstrual cycles as well as downregulate the levels of LH and testosterone in patients with PCOS. Study registration: PROSPERO CRD42019128574. Abbreviations: CC = clomiphene citrate, CI = confidence interval, CNKI = China National Knowledge Infrastructure, FSH = follicle-stimulating hormone, GnRH = gonadotropin-releasing hormone, GRADE = Grading of Recommendations Assessment, Development, and Evaluation, HCG = human chorionic gonadotropin, ICSI = intracytoplasmic sperm injection, IVF = in-vitro fertilization, LE= letrozole, LH= luteinizing hormone, LUFS= luteinized unruptured follicle syndrome, MD=mean difference, OCPs= oral contraceptive pills, PCOS = polycystic ovary syndrome, Revman = Review Manager software, RR = relative risk, SMD = standardized mean difference.
A systematic review and meta-analysis of randomized controlled trials

Background: The aim of this study was to determine the efficacy and safety of acupuncture treatment (AT) or acupuncture plus conventional medicine (CM) versus CM alone using a meta-analysis of all published randomized controlled trials (RCTs) for nonalcoholic fatty liver disease (NAFLD). Methods: Eight databases were searched independently from inception to April 30, 2020. RCTs were included if they contained reports on the use acupuncture or the use of acupuncture combined with CM and compared with the use of CM. Summary odds ratio (OR) and 95% confidence intervals (CIs) were used to calculate the overall clinical efficacy. Secondary outcomes, namely aspartate aminotransferase, alanine aminotransferase, total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and body mass index, were calculated by mean difference with 95% CIs. Results:After the final screening, 8 RCTs with 939 patients were included. This meta-analysis showed that AT was superior to CM in improving overall clinical efficacy (OR=3.19, 95% CI: 2.06–4.92, P< .00001). In addition, AT plus CM could significantly improve overall clinical efficacy compared to treatment with CM alone (OR=5.11, 95% CI: 2.43–10.75, P< .0001). Moreover, the benefits were also demonstrated in other outcomes, including alanine aminotransferase, aspartate aminotransferase, total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol indexes. However, AT plus CM could not decrease body mass index levels in comparison with CM. The safety profile of Acupuncture therapy was satisfactory. Taichong, Zusanli, Fenglong, and Sanyinjiao were major acupoints on NAFLD treatment. Conclusion: Acupuncture may be effective and safe for treatment of NAFLD. However, due to insufficient methodological quality and sample size, further high-quality studies are needed. Abbreviations: ALT = alanine aminotransferase, AST = aspartate aminotransferase, AT = acupuncture treatment, BMI = body mass index, CI = confidence interval, CM = conventional medicine, DGEC = diammonium glycyrrhizinate enteric capsule, EA = electroacupuncture, HDL-C = high-density lipoprotein cholesterol, LDL-C = low-density lipoprotein cholesterol, LR3 = Taichong acupoint, MA = manual acupuncture, MD = mean difference, NAFLD = nonalcoholic fatty liver disease, OR = odds ratio, PPC = polyene phosphatidylcholine capsule, RCTs = randomized controlled trials, SIL = silybin capsules, SP6 = Sanyinjiao acupoint, ST36 = Zusanli acupoint, ST40 = Fenglong acupoint, TC = total cholesterol, TET = thread embedding therapy, TG = triglyceride.
Distribution and sources of organic matter in surface sediments of the eastern continental margin of India

The sources and distribution of organic matter (OM) in surface sediments of the eastern continental margin of India, including the region influenced by river discharge, were investigated using content, molar C:N ratios and stable isotopes of carbon and nitrogen. Despite relatively high water column integrated chlorophyll‐a concentrations were found in the continental shelf than the slope; however, the lower sediment organic carbon (SOC) was found in the former than the latter region suggesting that in situ production did not play significant role on preservation of SOC in the coastal Bay of Bengal. The broad range of δ13C of SOC (−23.2 to −16.7‰) suggests that OM is a broad mixture of terrestrial and marine OM. Relative contributions from terrestrial C3 and C4 plants and marine sources are quantified as 34%, 23%, and 43%, respectively, indicating that dominant source of allochthonous OM (~57%) in the coastal Bay of Bengal. Relatively higher contribution of OM from C4 plants was found in the sediments at off river Krishna indicating that this region received detritus of agricultural crops such as jowar, bajra, and sugar cane, which are dominant in its drainage basin, during SW monsoon. This study revealed that relatively high OM preserved in the slope than shelf region along the coastal Bay of Bengal and the composition of OM is primarily controlled by the type of agricultural crops and vegetation in the drainage basin of the river.
INTERIM GEOLOGIC MAP OF UNCONSOLIDATED DEPOSITS IN THE SANTAQUIN QUADRANGLE, UTAH AND JUAB COUNTIES, UTAH

This open-file release makes information available to the public that may not conform to UGS technical, editorial, or policy standards; this should be considered by an individual or group planning to take action based on the contents of this report. Although this product represents the work of professional scientists, the Utah Department of Natural Resources, Utah Geological Survey, makes no warranty, expressed or implied, regarding its suitability for a particular use. The Utah Department of Natural Resources, Utah Geological Survey, shall not be liable under any circumstances for any direct, indirect, special, incidental, or consequential damages with respect to claims by users of this product.
IMPLEMETASI OFFLINE PENGENALAN SISTEM ISYARAT BAHASA INDONESIA MENGGUNAKAN METODE DYNAMIC TIME WARPING PADA PERANGKAT ANDROID

Algorithm Dynamic Time Warping (DTW) is used widely to various studies, one in the field of sign language. DTW is template matching algorithm to measure the similarity of the two data sequential (time series) with different time and speed. In this study are presented DTW algorithm implementation for the offline recognition of Indonesia sign language (Sistem Isyarat Bahasa Indonesia – SIBI). The dataset used in this study were 900 data for the number of grade 50 cue words, with details for each class is 3 the data as a data template and 15 of data as a data testing. The results show that the recognition rate or accuracy value is 89.73%. The average time needed is 654.59 milliseconds for the introduction of the testing of data using a data template as much as 3 per class or template total of 150 data.
The Label-Free Detection and Identification of SARS-CoV-2 Using Surface-Enhanced Raman Spectroscopy and Principal Component Analysis

The World Health Organization (WHO) declared in a May 2023 announcement that the COVID-19 illness is no longer categorized as a Public Health Emergency of International Concern (PHEIC); nevertheless, it is still considered an actual threat to world health, social welfare and economic stability. Consequently, the development of a convenient, reliable and affordable approach for detecting and identifying SARS-CoV-2 and its emerging new variants is crucial. The fingerprint and signal amplification characteristics of surface-enhanced Raman spectroscopy (SERS) could serve as an assay scheme for SARS-CoV-2. Here, we report a machine learning-based label-free SERS technique for the rapid and accurate detection and identification of SARS-CoV-2. The SERS spectra collected from samples of four types of coronaviruses on gold nanoparticles film, fabricated using a Langmuir–Blodgett self-assembly, can provide more spectroscopic signatures of the viruses and exhibit low limits of detection (<100 TCID50/mL or even <10 TCID50/mL). Furthermore, the key Raman bands of the SERS spectra were systematically captured by principal component analysis (PCA), which effectively distinguished SARS-CoV-2 and its variant from other coronaviruses. These results demonstrate that the combined use of SERS technology and PCA analysis has great potential for the rapid analysis and discrimination of multiple viruses and even newly emerging viruses without the need for a virus-specific probe.
Image Matching and Surface Registration for 3D Reconstruction of a Scoliotic Torso

The focus of this research is a hierarchical image matching strategy and a multiple surface registration technique for 3D reconstruction of a scoliotic torso. Scoliosis is a deformity of the human spine most commonly occurring in children. After being detected, periodic examinations via x-rays are traditionally used to measure its progression. However, due to the increased risk of cancer, non-invasive and radiation-free scoliosis detection and progression monitoring methodologies are being researched. For example, quantifying the scoliotic deformity through the torso surface is a valid alternative because of its high correlation with the internal spine curvature. This work proposes a low-cost, multi-camera photogrammetric system for semi-automated 3D reconstruction of a torso surface with a sub-millimetre level accuracy. The paper first describes the system design and calibration for optimal accuracy. It then covers the reconstruction and registration procedures giving insights into the hierarchical image.
Temporal and spatial variation in habitat quality : breeding ecology of the chestnut-backed chickadee in uncut and partial cut forests in British Columbia

I examined how partial cutting influenced the use and selection of habitat by chestnut-backed chickadees (Poecile rufescens). My objectives were: (1) to examine the variability of nest survival and identify the contributions of year, harvest treatment and habitat characteristics, and predator activity at 3 spatial scales, (2) to compare use and selection of nesting habitat in uncut, partial cut-mature, and partial cut-old sites at 3 spatial scales, and (3) to identify the influence of habitat structure or annual differences in food abundance and predation pressure on reproductive output. I found that nest predation rates fluctuated between years: 56% in 2000, 64% in 2001, 10% in 2002, and 12% in 2003. Survival models revealed that only the covariate year reliably predicted nest survival time at the stand and nest patch scales, while year and nest height predicted survival time at the nest tree scale. I found no effect of harvest treatment in the stand, nest patch, and nest tree models. Squirrel population density, space use, and activity near nest areas did not differ between years. Indirect effects on nest survival may have occurred due to temporal changes in habitat quality for squirrels. Chestnut-backed chickadees exhibited flexibility in resource selection when selecting nest sites. I found no correlation between the density of breeding chickadees and structural characteristics at the stand scale, but found selection of similar resources at the nest patch and nest tree scales. When selecting nest trees, chickadees in my system used a variety of tree species, conditions, sizes, nest site locations, and cavity types. Reproductive output showed no consistent pattern across sites, and was highly variable among years. Chickadee foraging patterns differed between years suggesting annual changes in prey abundance and type, although reproductive output did not decrease with a decline in primary prey. Predators had the greatest impact on the daily mortality rate of nesting chickadees. Indices of predator density did not differ among years; a functional response by predators due to changes in their food supply may have strongly influenced annual reproductive output of chickadees in this population. TABLE OF CONTENTS Abstract : i i Table of