Miracle-dz/UniFAR-FTUs huggingface dataset:
Prepregnancy body mass index, gestational weight gain, and the likelihood of major depressive disorder during pregnancy.

OBJECTIVE We assessed the relation between prepregnancy body mass index (BMI) and the likelihood of major depressive disorder (MDD) during pregnancy and tested whether this association was modified by gestational weight gain. METHOD Women (N = 242) were enrolled at < 20 weeks gestation into a prospective cohort study. Diagnosis of MDD was made with the Structured Clinical Interview for DSM-IV at 20, 30, and 36 weeks gestation. Gestational weight gain was compared with the 1990 Institute of Medicine weight gain recommendations. To assess the independent association between prepregnancy BMI and the odds of MDD, MDD at each time point was used as the dependent measure in a multivariable longitudinal logistic regression model employing generalized estimating equations. The data were collected from 2003-2007. RESULTS There was a strong, positive dose-response association between prepregnancy BMI and the likelihood of MDD (P = .002). Compared with a BMI of 18, the adjusted odds ratios (95% confidence interval) for BMIs of 23, 28, and 33 were 1.4 (1.1 to 1.7), 1.9 (1.3 to 2.9), and 2.6 (1.4 to 4.3), respectively. Gestational weight gain significantly modified this effect. Among women with weight gains within and above the 1990 Institute of Medicine recommendations, pregravid overweight was associated with a greater likelihood of MDD. In contrast, all women with weight gains below recommended levels had an elevated odds of depression regardless of their pregravid BMI (P < .05). CONCLUSIONS Because pregravid overweight, poor gestational weight gain, and MDD all pose substantial risks for fetal development and birth outcomes, health care providers should monitor depression levels in these women to facilitate appropriate depression intervention.
Physical mobile interaction with dynamic physical object

The proposed demonstration offers the possibility to access and interact with (web) services through Physical Mobile Interaction (PMI) with tag-based dynamic physical objects such as papers. Our demonstration supports several direct manipulation gestures in the real world and deals with physical objects able to provide system feedback to the user during the course of the interaction.
Optimal NBTI degradation and PVT variation resistant device sizing in a full adder cell

Aging phenomena, on top of process variations along with temperature and supply voltage variations, translate into complex degradation effects on the required performance and yield of nanoscale circuits. The proposed paper focuses on the development of mathematically optimal circuit sizing for yield maximization on the case study of a CMOS full adder circuit. The final cell design is robust against NBTI aging effects, impact of statistical (global and mismatch) and operating variation of temperature and supply voltage. Monte Carlo analysis has been carried out to verify the estimated yields. The demonstrated technique can be extended to a library of optimally designed digital cells.
Defining the Complexity of the Junctional Membrane Complex.

Each heart beat in every cardiac myocyte begins with the surface membrane depolarization during an action potential that opens L-type Ca2+ channels and allows the influx of a small amount of extracellular Ca2+ that triggers a larger release of Ca2+ from the intracellular store, the sarcoplasmic reticulum (SR), through ryanodine receptors (RyR2). 1,2 This process, known as Ca2+-induced Ca2+-release, is the primary mechanism underlying excitation–contraction coupling in the heart. Cardiac myocytes are relatively large cells, and efficient cardiac function requires not only the rapid sequential activation of contraction between cells but also the simultaneous activation of the contractile apparatus within each cell. To accomplish this, adult cardiac myocytes localize L-type Ca2+ channels in deep membrane invaginations known as transverse tubules (T-tubules), located along the Z-lines adjacent to the SR Ca2+ release channels in highly ordered structures known as dyads. The potential importance of these organized junctional membrane complexes has been defined during the last decade using in situ imaging techniques that show their loss in pathological conditions, including myocardial infarction and heart failure.3 Article, see p 110 …
A Basic Cluster Determines Topology of the Cytoplasmic M3-M4 Loop of the Glycine Receptor α1 Subunit*

The inhibitory glycine receptor is a member of the ligand-gated ion channel superfamily of neurotransmitter receptors, which are composed of homologous subunits with four transmembrane segments (M1-M4), each. Here, we demonstrate that the correct topology of the glycine receptor α1 subunit depends critically on six positively charged residues within a basic cluster, RFRRKRR, located in the large cytoplasmic loop (designated M3-M4 loop) following the C-terminal end of M3. Neutralization of one or more charges of this cluster, but not of other charged residues in the M3-M4 loop, led to an aberrant translocation into the endoplasmic reticulum lumen of the M3-M4 loop. However, when two of the three basic charges located in the ectodomain linking M2 and M3 were neutralized, in addition to two charges of the basic cluster, endoplasmic reticulum disposition of the M3-M4 loop was prevented. We conclude that a high density of basic residues C-terminal to M3 is required to compensate for the presence of positively charged residues in the M2-M3 ectodomain, which otherwise impair correct membrane integration of the M3 segment.
Wheelchair control based on a polynomial function approximating a user's gaze curve

We propose a new wheelchair control system based on a polynomial function approximating a user's gaze curve. Conventional studies utilizing gaze data recognized three wheelchair movements: "go straight," "turn right," and "turn left. " However, it was difficult for the system to assess when it should switch wheelchair motions because the user's gaze was always changing. To solve this problem, we divided "turn right" and "turn left" wheelchair movements into three groups each in order to control the wheelchair easily. Consequently, the system has to recognize seven wheelchair movements: straight, and three groups each for turning right and left. It is not sufficiency for a system to assess seven wheelchair movements by only the user's gaze. Thus, we developed a wheelchair system considering not only the user's gaze but also the angular velocity and acceleration to control wheelchair motions. We approximated the user's gaze using a polynomial function, and calculated the fine gaze angle, angular velocity and acceleration. The effectiveness of the proposed method was shown by experimental results.
Superior Pattern Detectors Efficiently Learn, Activate, Apply, and Update Social Stereotypes

Superior cognitive abilities are generally associated with positive outcomes such as academic achievement and social mobility. Here, we explore the darker side of cognitive ability, highlighting robust links between pattern detection and stereotyping. Across 6 studies, we find that superior pattern detectors efficiently learn and use stereotypes about social groups. This pattern holds across explicit (Studies 1 and 2), implicit (Studies 2 and 4), and behavioral measures of stereotyping (Study 3). We also find that superior pattern detectors readily update their stereotypes when confronted with new information (Study 5), making them particularly susceptible to counterstereotype training (Study 6). Pattern detection skills therefore equip people to act as naïve empiricists who calibrate their stereotypes to match incoming information. These findings highlight novel effects of individual aptitudes on social–cognitive processes.
Security Enhancement of the Telemedicine and Remote Health Monitoring Models

The telemedicine applications are the application utilized for the remote monitoring and health assessment of the people living in the remote areas. The networks of the doctors and the field executives utilizes the various kinds of the healthcare sensors for the health checkup of the people by collecting and transmitting over the internet for the treatment of the affected ones. The information being propagated through the internet between the healthcare sensors and the online server model is always prone to the several forms o the attacks. In this paper, the proposed model has been designed to improve the level of security over the telemedicine network. The proposed model will be improved by using the robust encryption with the highly scrambled authentication key. The performance of the proposed model will be assessed under the various performance parameters which define the network health as well as the security level.
Clustering of Psychosocial Symptoms in Overweight Children

Objective: The aims of the present study were to (i) examine the relationship between children's degree of adiposity and psychosocial functioning; and (ii) compare patterns of clustering of psychosocial measures between healthy weight and overweight/obese children. Method: Cross-sectional data from a population-based cohort of 158 healthy weight, 77 overweight, and 27 obese children aged 8–13 years were analysed. Height, weight depression, quality of life, self-esteem, body dissatisfaction, eating disorder symptoms, peer relationships and behavioural and emotional problems were measured. Results: Multi-level analysis showed significant linear associations between child body mass index z-scores and the psychosocial variables, with increasing adiposity associated with increasing levels of psychosocial distress. Principal components analyses indicated subtle differences between the healthy weight and overweight/obese groups with regards to the clustering of psychosocial measures. In particular, in overweight/obese, but not in healthy weight children, global self-worth clustered with body image and eating disorder symptoms. Conclusions: The psychosocial burden of excess weight is significant and broad reaching, with overweight/obese children showing multiple significant psychosocial problems.
Magnesium-sensitive guanylate cyclase and its endogenous activating factor in Tetrahymena pyriformis.

Guanylate cyclase [EC 4.6. 1.2] activity in Tetrahymena pyriformis cells was associated with particulate fractions, but not with soluble fractions. Mg2+ was much more effective than Mn2+ in activating the cyclase activity. Both specific and total cyclase activities with Mg2+ in the particulate fraction were very much lower than those in the original homogenate. The addition of the soluble fraction resulted in a marked enhancement of the particulate-bound cyclase activity, while the adenylate cyclase [EC 4.6. 1.1] activity was not enhanced. The enhancement was dependent on Ca2+, and the activating factor is suggested to be a protein.
Aberrations in the micro‐RNA biogenesis machinery and the emerging roles of micro‐RNAs in the pathogenesis of cutaneous malignant melanoma

Micro‐RNAs (miRNAs) are small noncoding RNAs that play roles in the posttranscriptional regulation of gene expression. Since the seminal discovery that aberrant miRNA expression has a causative role in leukemogenesis, the involvement of miRNAs in cancer initiation, propagation, and metastasis has been widely studied. In this review, we provide a comprehensive summary of the literature on miRNAs in melanoma, specifically focusing on aberrations in cellular miRNA biogenesis and processing. These aberrations include genetic and epigenetic changes at the chromosomal level, alterations in the level of the miRNA‐processing enzyme DICER, and the existence of competitive endogenous RNAs that serve as decoys for miRNAs and thus modulate their effective intracellular concentrations. We also discuss miRNA profiling in melanoma, review several miRNAs implicated in invasion, metastasis, proliferation, and apoptosis, and briefly summarize the cross talk between miRNAs and microphthalmia‐associated transcription factor, the master transcriptional regulator of the melanocyte lineage. Finally, we summarize recent studies of miRNA expression as prognostic and predictive biomarkers, as well as initial experiments on the use of miRNAs and small interfering RNAs as therapeutic agents in melanoma.
Residential Exposure to Estrogen Disrupting Hazardous Air Pollutants and Breast Cancer Risk: The California Teachers Study

Background: Some studies show increased breast cancer risk from exposure to xenoestrogens, but few have explored exposures via ambient air, which could impact large populations. Objectives: This study explored the association between breast cancer risk and residential exposures to ambient estrogen disruptors among participants in a large cohort study, the California Teachers Study. Methods: Participants consisted of 112,379 women free of breast cancer and living at a California address in 1995/1996. Eleven hazardous air pollutants from the US Environmental Protection Agency 2002 list were identified as estrogen disruptors based on published endocrine disrupting chemical lists and literature review. Census-tract estrogen disruptor air concentrations modeled by the US Environmental Protection Agency in 2002 were assigned to participants’ baseline addresses. Cox proportional hazards models were used to estimate hazard ratios associated with exposure to each estrogen disruptor and a summary measure of nine estrogenic hazardous air pollutants among all participants and selected subgroups, adjusting for age, race/birthplace, socioeconomic status, and known breast cancer risk factors. Results: Five thousand three hundred sixty-one invasive breast cancer cases were identified between 1995 and 2010. No associations were found between residential exposure to ambient estrogen disruptors and overall breast cancer risk or hormone receptor-positive breast cancer risk, nor among targeted subgroups of participants (pre-/peri-menopausal women, post-menopausal women, never-smokers, non-movers, and never-smoking non-movers). However, elevated risks for hormone receptor-negative tumors were observed for higher exposure to cadmium compounds and possibly inorganic arsenic among never-smoking non-movers. Conclusion: Long-term, low-dose exposure to ambient cadmium compounds or possibly inorganic arsenic may be a risk factor for breast cancer.
Parallels in the epidemiology of selected anogenital carcinomas.

Characteristics of Los Angeles, Calif. , residents in whom carcinomas of the cervix, vulva, vagina, anus, and penis were diagnosed during the period 1972-81 were compared with those of all residents and with those in whom any cancer was diagnosed during the same period. At all five sites, risks for squamous and transitional cell carcinomas generally increased with decreasing social class, were low among Jews (not explained by social class), and were elevated among persons who were separated or divorced at diagnosis compared to married persons. Single men had a striking excess of anal but not penile carcinomas. The five sites represent contiguous and histologically similar tissues, and the clinical literature suggests common risk factors, e.g., sexually transmitted infections and other forms of chronic irritation. These observations are all consistent with the hypothesis that tumors at these sites have common or similar etiologic elements.
In vivo evidence that acyl coenzyme A regulates DNA binding by the Escherichia coli FadR global transcription factor

In vitro experiments point to fatty acyl coenzymes A (acyl-CoAs) rather than unesterified fatty acids as the small-molecule ligands regulating DNA binding by the FadR protein of Escherichia coli. To provide an in vivo test of this specificity, unesterified fatty acids were generated within the cellular cytosol. These fatty acids were found to be efficient modulators of FadR action only when the acids could be converted to acyl-CoAs.
Neurogenic locus notch homolog protein 4 and brain-derived neurotrophic factor variants combined effect on schizophrenia susceptibility

Objectives To investigate the relationships between single-nucleotide polymorphisms (SNPs) in NOTCH4 and brain-derived neurotrophic factor (BDNF) with schizophrenia among Han Chinese in Southern China. Methods Two NOTCH4 SNPs (rs520688 and rs415929) and two BDNF SNPs (rs2030324 and rs12273539) were examined in 464 schizophrenics and 464 healthy controls from Hunan province in South China, using the Sequenom MassARRAY® iPLEX System. Results In the study population, rs520688 and rs2030324 were significantly associated with schizophrenia. A decreased risk of schizophrenia was associated with the rs520688 GA genotype (p = 0.035), whereas an increased risk of schizophrenia was associated with the rs2030324 CC/CT genotype (p = 0.044). The genotype distributions of rs415929 in NOTCH4 and rs12273539 in BDNF did not differ significantly between the case and control groups. Although no allele–allele interactions were detected between rs520688 and rs2030324, recombination analysis revealed a combined effect of the two on the susceptibility to schizophrenia, with GA-TT decreasing and CT/CC-GG/GA increasing the risk of schizophrenia. Conclusion In conclusion, rs520688 in NOTCH4 and rs2030324 in BDNF are significantly associated with schizophrenia among Han Chinese in Southern China. The two had a combined effect on the susceptibility to schizophrenia among Han Chinese in Southern China, but this may not be caused by an allele–allele interaction.
Hodgkin and reed-sternberg cells in bone marrow aspirations of a patient with advanced classical hodgkin lymphoma

INTRODUCTION Hodgkin Lymphoma (HL) is a group of lymphomas of mainly nodal origin with similar clinical and histological features (1). HL encompasses 95% of classical Hodgkin lymphomas (CHL) and the rest are of nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). These two entities differ in their aetiology, clinical features, histopathological features, immunophenotype and molecular genetic features. NLPHL is an uncommon monoclonal B cell neoplasm characterized by large neoplastic cells known as popcorn or lymphocyte predominant cells (LP cells) in an inflammatory background. NLPHL is considered to be of germinal centre B-cell origin. It is managed differently from classical HL. The prognosis is good; however, late relapses and transformation to high grade non-Hodgkin lymphoma can occur (1,2).
Relationship intention and satisfaction following service recovery : the mediating role of perceptions of service recovery in the cell phone industry

In an industry characterised by fierce competition, cell phone network providers find it increasingly difficult to retain their customers after service failure. It is therefore essential for cell phone network providers to offer effective service recovery when they attempt to restore customer satisfaction following service failure. As it has been argued that relationships between customers and service providers should be considered a key determinant of the service recovery required to restore post-recovery attitudes and behavioural intentions, the purpose of this study was to determine the relationships between South African cell phone customers’ relationship intentions, their perceptions of service recovery and their satisfaction following service recovery. Personal in-home interviews were conducted to collect data from 605 cell phone customers residing in the Johannesburg metropolitan area. In addition to the significant positive relationships found between cell phone users’ relationship intentions, perceived service recovery and satisfaction after service recovery, this study found that perceived service recovery played a mediating role in the relationship between relationship intention and satisfaction following service recovery. The study concludes that, although a direct relationship exists between relationship intention and satisfaction following service recovery, perceived service recovery plays an additional indirect complementary role in this relationship. It is recommended that, in addition to focusing their relationship efforts on customers with relationship intentions, cell phone network providers also offer positively perceived service recovery to these customers, as this would lead to greater satisfaction following service recovery.
Artificial neural networks for impact force reconstruction on composite plates

Impacts are one of the main causes of damage in composite panels. The determination of the impact location and the reconstruction of impact force are necessary to evaluate the health of the structure. These data may be measured indirectly from the measurements of responses of sensors located on the system subjected to the impact. In this study, a composite panel model developed in Abaqus/CAE is first validated and then numerical simulations based on the model are used to obtain data for several impacts, characterized by different impact locations, different impactor velocities and masses. Subsequently, these data are used to model the complex nonlinear behavior of the composite laminate by a nonlinear system identification approach. This is based on the use of artificial neural networks, which are employed to accurately reconstruct the impact forces and the impact locations.
Challenges Facing Employers in the Treatment of Depression

OBJECTIVE To review the challenges of treating depression in the workplace in the environment of increased health care costs. SUMMARY The cost of health care is on the rise, and employers and employees are at odds over who will share the burden of these costs. The focus of cost containment has been to minimize drug cost; however, employers need to be aware of indirect costs of medical illness. Due to its prevalence and rate of undertreatment, depression is one of the main disease states that employers should target in their disease management efforts. CONCLUSION In order to treat depression appropriately, we must consider the social stigma, treatment barriers, and health care structure that exist to treat depression. Additional outcomes data is needed to demonstrate to employers, the largest purchasers of health care, the benefit of managing depression in the workplace.