Miracle-dz/UniFAR-FTUs huggingface dataset:
Cell-Penetrating Dabcyl-Containing Tetraarginines with Backbone Aromatics as Uptake Enhancers

Cell-penetrating peptides represent an emerging class of carriers capable of effective cellular delivery. This work demonstrates the preparation and investigation of efficient CPPs. We have already shown that the presence of 4-((4-(dimethylamino)phenyl)azo)benzoic acid (Dabcyl) and Trp greatly increase the uptake of oligoarginines. This work is a further step in that direction. We have explored the possibility of employing unnatural, aromatic amino acids, to mimic Trp properties and effects. The added residues allow the introduction of aromaticity, not as a side-chain group, but rather as a part of the sequence. The constructs presented exceptional internalization on various cell lines, with an evident structure–activity relationship. The CPPs were investigated for their entry mechanisms, and our peptides exploit favorable pathways, yet one of the peptides relies highly on direct penetration. Confocal microscopy studies have shown selectivity towards the cell lines, by showing diffuse uptake in FADU cells, while vesicular uptake takes place in SCC-25 cell line. These highly active CPPs have proved their applicability in cargo delivery by successfully delivering antitumor drugs into MCF-7 and MDA-MB-231 cells. The modifications in the sequences allow the preparation of short yet highly effective constructs able to rival the penetration of well-known CPPs such as octaarginine (Arg8).
The Reddening law outside the local group galaxies: The case of NGC 7552 and NGC 5236

The dust reddening law from the UV to the near-IR for the extended regions of galaxies is here derived from the spectral distributions of the starburst spiral galaxies NGC 7552 and NGC 5236. The centers of these galaxies have similar absorption and emission line spectra, differing only if the strength of their interstellar lines and in the continuum distribution, with NGC 7552 appearing more reddened than NGC 5236. The disk of NGC 7552 is more inclined, and there is evidence that its center is observed through additional foreground dust and gas clouds, as compared to the center of NGC 5236. While the galaxies can be expected to have similar dust content, they are known to have different dust path lengths to our line of sight. Therefore, differences in the shape of the spectra can be attributed mainly to the effects of dust, allowing us to probe for the first time the properties of the reddening law outside the local group of galaxies. We derive the reddening law based on the optical depth of the emission line of H Alpha and H Beta and also based on the continuum distribtuion. We find that the optical depth from the emission line regions are about twice the optical depth of the continuum regions. Thus, dereddening a starburst galaxy by scaling the Milky Way reddening laws to optical depths obtained from the H Alpha/H Beta line ratio overcompensates for the effect of dust.
e-Shaped Slot Antenna for WLAN Applications

This paper present an e-shaped slot antenna for wireless communications. The antenna is designed for dual frequency band 2.4{2.52GHz and 4.82{6.32GHz, which support WLAN communications coverage IEEE 802.11b/g (2.4{2.4835GHz), IEEE 802.11j (4.90{5.091), IEEE 802.11a (5.15{5.35GHz), and IEEE 802.16d (5.7{5.9GHz). The bandwidth at low reso- nant frequency and high resonant frequency are about 0.12GHz and 1.5GHz, respectively. The simulation results of e-shaped slot antenna are analyzed by using Method of Moment (MoM) from IE3D Software. DOI: 10.2529/PIERS061007105447
Stress Engineering During Metalorganic Chemical Vapor Deposition of AlGaN/GaN Distributed Bragg Reflectors

In situ stress monitoring has been employed during metalorganic chemical vapor deposition of AlGaN/GaN distributed Bragg reflectors (DBRs). It was found that the insertion of multiple AlN interlayers is effective in converting the tensile growth stress typically observed in this system into compression, thus alleviating the problem of crack generation. Crack-free growth of a 60 pair Al0.20Ga0. 80N/GaN quarter-wavelength DBR was obtained over the entire 2 in. wafer; an accompanying reflectivity of at least 99% was observed near the peak wavelength around 380 nm.
Excited state coherent dynamics in light-harvesting complexes from photosynthetic marine algae

We explore coherence dynamics in light-harvesting complexes and their interactions with other electronic states and vibrational modes. This is achieved by utilizing a two-colour four-wave mixing spectroscopy to excite and analyse a specific coherence pathway in the phycocyanin-645 (PC645) light-harvesting complex. We observe the dephasing rate increase as a function of temperature and oscillations in the signal intensity as a function of waiting time which reveals coherent excitation of pathways not directly resonant with the laser pulses. This coherent excitation of non-resonant electronic states implies strong coupling to phonon modes, which is necessary if coherent energy transfer between non-resonant states is to play any role in photosynthetic energy transfer.
Triple and generalized triple derivations of the parabolic subalgebras of the general linear Lie algebra over a commutative ring

Let R be an arbitrary commutative ring with identity and be the general linear Lie algebra over R. Let P be a parabolic subalgebra of . The main aim of this article is to describe triple derivations and generalized triple derivations of P. We show that any triple derivation of P can be uniquely expressed as a sum of standard triple derivations and any generalized triple derivation of P can be expressed as a sum of a scalar map and a triple derivation.
Modelling of extremely high concentration erbium-doped silica waveguides

A comprehensive model is presented of erbium-doped integrated optical waveguide amplifiers that include high concentration dissipative ion-ion interactions. Calculations based on actual waveguide parameters closely reproduce measured gains for different pump powers and different erbium concentrations up to 60*10/sup 24/m/sup -3/. The quenching concentration for erbium-doped phosphate glass is found to be 20-30*10/sup 24/m/sup -3/.
Fluid Friction between Rotating Cylinders. II. Distribution of Velocity between Concentric Cylinders when Outer One Is Rotating and Inner One Is at Rest

Measurements of the distribution of velocity between two cylinders when the outer one is at rest have been made by means of small Pitot tubes. The Pitot was traversed in from the outer wall towards the inner cylinder and the difference in pressure P between the Pitot tube and a hole in the outer cylinder was measured. The connexion between the velocity U and P is 2/ρ∫p r2d P = U2 r , (1) where U is the velocity at radius r . A similar method can be used to determine the velocity between rotating cylinders when the inner cylinder is fixed and the outer one rotates. The small Pitot tube must now be fixed projecting from the inner cylinder. The formula (1) still applies for determining U. It may be conveniently expressed in the form 2/ρ∫p d P/N2 = U2 r 2/N2, (2) where N is the number of revolutions of the outer cylinder per second.
The roles of proteases in prostate cancer

Since the proposition of the pro‐invasive activity of proteolytic enzymes over 70 years ago, several roles for proteases in cancer progression have been established. About half of the 473 active human proteases are expressed in the prostate and many of the most well‐characterized members of this enzyme family are regulated by androgens, hormones essential for development of prostate cancer. Most notably, several kallikrein‐related peptidases, including KLK3 (prostate‐specific antigen, PSA), the most well‐known prostate cancer marker, and type II transmembrane serine proteases, such as TMPRSS2 and matriptase, have been extensively studied and found to promote prostate cancer progression. Recent findings also suggest a critical role for proteases in the development of advanced and aggressive castration‐resistant prostate cancer (CRPC). Perhaps the most intriguing evidence for this role comes from studies showing that the protease‐activated transmembrane proteins, Notch and CDCP1, are associated with the development of CRPC. Here, we review the roles of proteases in prostate cancer, with a special focus on their regulation by androgens.
BGCFI: Efficient Verification in Fine-Grained Control-Flow Integrity Based on Bipartite Graph

Control-flow integrity (CFI) is considered a principled mitigation against control-flow hijacking even under the most powerful attacker who can arbitrarily write and read memory. However, existing schemes still demonstrated limitations in either guaranteeing high security level or achieving low performance and memory overhead. These limitations have restricted the application of CFI in real software. To improve its applicability similar to mandatory protection schemes such as DEP and ASLR, it is essential to improve both high security guarantee and low overhead. In this paper, we propose “BGCFI”, which is a fine-grained CFI based on a Bipartite Graph. The relationship between an indirect branch and a valid target address at the branch is represented by an edge in the bipartite graph. The verification of the indirect branch is achieved by checking the existence of the corresponding edge in the bipartite graph. The verification method for fine-grained CFI results in more efficiency on both computational and memory overhead, while completely preserving high security guarantee. We demonstrate our results through the implementation of a proof-of-concept module and evaluation on the SPEC CPU 2017 suite and the Firefox browser.
Deciphering the Role of microRNA Mediated Regulation of Coronin 1C in Glioblastoma Development and Metastasis

Glioblastoma multiforme (GBM) is a highly heterogenic and malignant brain tumour with a median survival of 15 months. The initial identification of primary glioblastomas is often challenging. Coronin 1C (CORO1C) is a key player in actin rearrangement and cofilin dynamics, as well as enhancing the processes of neurite overgrowth and migration of brain tumour cells. Different bioinformatic databases were accessed to measure CORO1C expression at the mRNA and protein level in normal and malignant brains. CORO1C expression was observed in brain regions which have retained high synaptic plasticity and myelination properties. CORO1C was also expressed mainly within the hippocampus formation, including the Cornu Ammonis (CA) fields: CA1–CA4. Higher expression was also noticed in paediatric GBM in comparison to their adult counterparts. Pediatric cell populations were observed to have an increased log2 expression of CORO1C. Furthermore, 62 miRNAs were found to target the CORO1C gene. Of these, hsa-miR-34a-5p, hsa-miR-512-3p, hsa-miR-136-5p, hsa-miR-206, hsa-miR-128-3p, and hsa-miR-21-5p have shown to act as tumour suppressors or oncomiRs in different neoplasms, including GBM. The elevated expression of CORO1C in high grade metastatic brain malignancies, including GBM, suggests that this protein could have a clinical utility as a biomarker linked to an unfavorable outcome.
Hybrid Refractive-Diffractive Lens with Reduced Chromatic and Geometric Aberrations and Learned Image Reconstruction

In this paper, we present a hybrid refractive-diffractive lens that, when paired with a deep neural network-based image reconstruction, produces high-quality, real-world images with minimal artifacts, reaching a PSNR of 28 dB on the test set. Our diffractive element compensates for the off-axis aberrations of a single refractive element and has reduced chromatic aberrations across the visible light spectrum. We also describe our training set augmentation and novel quality criteria called “false edge level” (FEL), which validates that the neural network produces visually appealing images without artifacts under a wide range of ISO and exposure settings. Our quality criteria (FEL) enabled us to include real scene images without a corresponding ground truth in the training process.
Enhanced sensitivity near-field scanning optical microscopy at high spatial resolution

An apertureless near-field optical-imaging method is presented that achieves high spatial resolution as well as a ∼4000-fold increase in detection sensitivity, by exploiting the highly localized enhanced near-field interactions between the sample (e.g., Au nanospheres) and a sharp atomic force microscope tip under evanescent laser field illumination. This represents a general method for optical imaging at ⩽2 nm spatial resolution, and is applicable to both resonant (i.e., scattering) as well as nonresonant (i.e., fluorescence, Raman, etc.) spectroscopic methods.
Nonlocal Correlations in Macroscopic Systems: Living Objects, Mental Influence and Physical Processes

The paper presents the result of studies carried out with the help of device developed by us where the measured parameter is the intensity of scattered light inside closed casing. The device allows to non-invasively and remotely detecting signals from biological objects (plants, animals and human), as well as physical processes. From other side, the inanimate substances in environment temperature do not affect device’s signals, except water. Also it is established that some persons with high extrasensory abilities (i.e. healers) can influence the signals form. It is shown that the variation of the device’s readings depends on various factors, characterizing the experimental conditions, i.e. influence of observer and studied object. Particularly, it is shown that signals’ changes characterize the physiological state of biological systems and the device can serve as a novel biomedical instrument. The analysis of the registered signals carried out by the software packages OriginPro and LabView has proved that observed effects are statistically reliable and always reproducible. It is found out that the nature of observed phenomena is not associated with known classical interaction channels. A concept that explains these effects, based on the quantum mechanical approach is proposed.
A new control strategy for induction motor based on non-linear predictive control and feedback linearization

Proposed in this paper is a new approach of design using a monovariable generalized predictive control law, with multiple reference model (GPC/MRM) to control, firstly, rotor speed and rotor flux amplitude of an induction machine. The control law will be extended and applied, secondly, to answer a second objective which is the control of the rotor position and rotor flux amplitude of the same machine. The non-linear dynamical model of the machine is described in the stator fixed reference frame. The GPC algorithm is combined with the non-linear input–output linearizing control properties; moreover, we establish a new formulation of the reference signals, which enables one to track flux and speed/position nominal profiles, satisfying motor constraints. The global controller synthesis is given under an RST form which introduces a novel definition of the prefiltering polynomial. Copyright © 2000 John Wiley & Sons, Ltd.
Wide-field subsecond temporal resolution optical monitoring systems for the detection and study of cosmic hazards

not correspond any more to a specific object’s trajectory but restricts the region of its possible trajectories. The stellar magnitude onthisintervalcorrespondstothelightfluxfromtheobjectper pixel (its surface brightness) and the detection limit of the instrument, which can reveal the object at a given distance. The break of the curve, determinedbytheexposuretime,inallcases(thehorizontaldashedlinesinFig.3)butthatshowninFig.4,ispositionedsignificantlybelowthedetectionlimitofthecorrespondinginstruments.
On confidence regions of semiparametric nonlinear reproductive dispersion models

This article investigates the confidence regions for semiparametric nonlinear reproductive dispersion models (SNRDMs), which is an extension of nonlinear regression models. Based on local linear estimate of nonparametric component and generalized profile likelihood estimate of parameter in SNRDMs, a modified geometric framework of Bates and Wattes is proposed. Within this geometric framework, we present three kinds of improved approximate confidence regions for the parameters and parameter subsets in terms of curvatures. The work extends the previous results of Hamilton et al. [in Accounting for intrinsic nonlinearity in nonlinear regression parameter inference regions, Ann. Statist. 10, pp. 386–393, 1982], Hamilton [in Confidence regions for parameter subset in nonlinear regression, Biometrika, 73, pp. 57–64, 1986], Wei [in On confidence regions of embedded models in regular parameter families (a geometric approch), Austral. J. Statist. 36, pp. 327–338, 1994], Tang et al. [in Confidence regions in quasi-likelihood nonlinear models: a geometric approach, J. Biomath. 15, pp. 55–64, 2000b] and Zhu et al. [in On confidence regions of semiparametric nonlinear regression models, Acta. Math. Scient. 20, pp. 68–75, 2000].
A Fully Passive Ten-Digit Numeric Keypad Sensor Using Chipless RFID Technology

A ten-digit chipless radio frequency identification (CRFID)-based numeric keypad that works on the principle of touch event sensing is presented. The tag is designed to operate using the passive frequency-domain (FD) technique. The proposed tag has ten circular resonator rings for each of the keypad’s corresponding decimal digits. Each circular ring resonates at a particular frequency within the 400-MHz band from 2.7 to 7.6 GHz to uniquely identify a digit. Identification is performed by decoding radar cross Section (RCS) response of the whole keypad tag. A customized human finger using standard tissue characteristics is modeled to verify the keypad’s working mechanism. When the finger is placed on any of the nine resonators, its corresponding resonance disappears from the allocated band. The proposed CRFID keypad sensor tag is built upon a Rogers substrate of $85\times 95\times0.8$ mm volume. The backside of the proposed tag is fully copper filled for an easy interface with a variety of backgrounds, including metallic walls. The design exactly mimics the shape of ordinary keypad. The finger model used in the simulations realizes the practical scenario. This CRFID keypad is deemed an intriguing solution for future automated cities and will help in the conceptualization of Internet of Things (IoT) systems.
Intranasal Administration of KYCCSRK Peptide Rescues Brain Insulin Signaling Activation and Reduces Alzheimer’s Disease-like Neuropathology in a Mouse Model for Down Syndrome

Down syndrome (DS) is the most frequent genetic cause of intellectual disability and is strongly associated with Alzheimer’s disease (AD). Brain insulin resistance greatly contributes to AD development in the general population and previous studies from our group showed an early accumulation of insulin resistance markers in DS brain, already in childhood, and even before AD onset. Here we tested the effects promoted in Ts2Cje mice by the intranasal administration of the KYCCSRK peptide known to foster insulin signaling activation by directly interacting and activating the insulin receptor (IR) and the AKT protein. Therefore, the KYCCSRK peptide might represent a promising molecule to overcome insulin resistance. Our results show that KYCCSRK rescued insulin signaling activation, increased mitochondrial complexes levels (OXPHOS) and reduced oxidative stress levels in the brain of Ts2Cje mice. Moreover, we uncovered novel characteristics of the KYCCSRK peptide, including its efficacy in reducing DYRK1A (triplicated in DS) and BACE1 protein levels, which resulted in reduced AD-like neuropathology in Ts2Cje mice. Finally, the peptide elicited neuroprotective effects by ameliorating synaptic plasticity mechanisms that are altered in DS due to the imbalance between inhibitory vs. excitatory currents. Overall, our results represent a step forward in searching for new molecules useful to reduce intellectual disability and counteract AD development in DS.
Significantly Suppressed Dielectric Loss and Enhanced Breakdown Strength in Core@Shell Structured Ni@TiO2/PVDF Composites

An insulating shell on the surface of conductive particles is vital for restraining the dielectric loss and leakage current of polymer composites. So as to inhibit the enormous loss and conductivity of pristine nickel (Ni)/poly(vinylidene fluoride)(PVDF) composites but still harvest a high dielectric permittivity (εr) when filler loading approaches or exceeds the percolation threshold (fc), pristine Ni particles were covered by a layer of titanium dioxide (TiO2) shell via a sol–gel approach, and then they were composited with PVDF. The impacts of the TiO2 coating on the dielectric performances of the Ni/PVDF composites were explored as a function of the filler concentration, the shell thickness and frequency. In addition, the dielectric performances were fitted using the Havriliak–Negami (H–N) equation in order to further understand the TiO2 shell’s effect on polarization mechanism in the composites. The Ni@TiO2/PVDF composites exhibit high εr and enhanced breakdown strength (Eb) but remarkably suppressed loss and conductivity when compared with pristine Ni/PVDF because the TiO2 shell can efficiently stop the direct contact between Ni particles thereby suppressing the long–range electron transportation. Further, the dielectric performances can be effectively tuned through finely adjusting the TiO2 shell’ thickness. The resulting Ni@TiO2/PVDF composites with high εr and Eb but low loss show appealing applications in microelectronics and electrical fields.
Effects of cane- and spur-retained node numbers on the pre-flowering vegetative growth of cane-pruned Sauvignon blanc

In established vineyards, node number retention at winter pruning is the first step to achieving and maintaining vine balance. Balanced vines exhibit timely and quasi-uniform 100 percent budburst. To understand how vine capacity and balance are expressed before flowering, mature Sauvignon blanc vines were pruned according to a 5 [total node numbers on canes: 10, 20, 30, 40, 50] x 3 [total node numbers on spurs: 1, 2, 3] factorial design in one site, and in two other sites according to a 5 [total node numbers on canes: 10, 20, 30, 40, 50] x 2 [total node numbers on spurs: 1, 2] factorial design. Two spurs of one, two or three nodes each were retained on either side of the vine. The number of canes laid down per vine was one, two, three and four canes each of 10 nodes for the 10-, 20-, 30- and 40-node treatments, and four canes averaging 12.5 nodes for the 50-node treatment. The budburst percentage was calculated on the whole vine, canes, and spurs. Blind nodes, count shoots, non-count shoots and double shoots were counted and mapped along canes and spurs. Many non-count shoots were measured on the vine head of 10-node vines (29.5 ± 3.0 shoots, p < 0.001), compared to 50-node vines (2.8 ± 1.9 shoots, p < 0.001). 50-node vines had an overall budburst of 100 %, despite having the highest number of blind nodes (7.6 ± 0.3 nodes, p < 0.001). These were mainly located at the canes’ proximal sections relative to the vine head and were likely caused by correlative inhibition and primary bud necrosis. Cane budburst provided a more accurate assessment of the vine response to node loading than vine budburst. The number of double shoots was not associated with the vine node load, as they appeared on both low-node and high-node vines. Three-node spurs developed more blind nodes than one-node and two-node spurs (p < 0.001). Based on the findings of this research, we recommend a composite metric (cane percent budburst, cane blind node count and head shoot count) to assess vine capacity and balance between budburst and flowering, and the practice of retaining one- or two-node spurs at cane pruning is also justified.