Miracle-dz/UniFAR-FTUs huggingface dataset:
A Case of Cushing's Syndrome due to Ectopic Adrenocorticotropic Hormone Secretion from Esthesioneuroblastoma with Long Term Follow-Up after Resection

We present a case of a 52-year-old male who developed Cushing's Syndrome due to ectopic adrenocorticotrophic hormone (ACTH) secretion from a large esthesioneuroblastoma (ENB) of the nasal sinuses. The patient initially presented with polyuria, polydipsia, weakness, and confusion. Computed tomography scan of the head and magnetic resonance imaging showed a 7 cm skull base mass centered in the right cribriform plate without sella involvement. Work-up revealed ACTH-dependent hypercortisolemia, which did not suppress appropriately after high-dose dexamethasone. Subsequent imaging of the chest, abdomen, and pelvis did not reveal other possible ectopic sources of ACTH secretion besides the ENB. His hospital course was complicated by severe hypokalemia and hyperglycemia before successful surgical resection of the tumor, the biopsy of which showed ENB. Postoperatively, his ACTH level dropped below the limit of detection. In the ensuing 4 months, he underwent adjuvant chemoradiation with carboplatin and docetaxel with good response and resolution of hypokalemia and hyperglycemia, with no sign of recurrence as of 30 months postoperatively. His endogenous cortisol production is rising but has not completely recovered.
The Pharmacokinetics of Beraprost Sodium Following Single Oral Administration to Subjects With Impaired Kidney Function

The purpose of the present study was to evaluate the pharmacokinetics of beraprost sodium (BPS) and its active enantiomer, BPS‐314d, in Japanese subjects with impaired kidney function. The plasma and urine concentrations of BPS and BPS‐314d were measured following the single oral administration of 120 μg of BPS as the sustained‐release tablet, TRK‐100STP, under fasting conditions to 18 subjects with impaired kidney function (stage 2, 3, and 4 chronic kidney disease [CKD] as categorized by the estimated glomerular filtration rate) and to 6 age‐, body weight‐, and gender‐matched subjects with normal kidney function (stage 1 CKD). The Cmax values (mean ± SD) of BPS in stage 1, 2, 3, and 4 CKD, respectively, were 84.9 ± 22.9, 119.8 ± 36.4, 190.6 ± 137.3, and 240.2 ± 110.5 pg/mL; its AUC0‐48h were 978 ± 226, 1252 ± 427, 1862 ± 964, and 1766 ± 806 pg·h/mL, respectively, and its cumulative urinary excretion rates were 0.704 ± 0.351%, 0.638 ± 0.292%, 0.485 ± 0.294%, and 0.159 ± 0.136%. The Cmax values of BPS‐314d were 22.4 ± 6.4, 30.8 ± 8.5, 46.7 ± 30.6, and 54.4 ± 25.2 pg/mL, its AUC0‐48h were 155 ± 56, 226 ± 67, 341 ± 176, and 329 ± 143 pg·h/mL, and its cumulative urinary excretion rates were 0.428 ± 0.242%, 0.349 ± 0.179%, 0.356 ± 0.270%, and 0.096 ± 0.099%, respectively. Adverse events were reported in 2 subjects with stage 2 CKD and 1 subject with stage 4 CKD. The Cmax and AUC0‐48h of BPS and BPS‐314d were higher based on the severity of impaired kidney function. No relationship was observed between the incidence of adverse events and the severity, and tolerability was confirmed. We consider that dose adjustment is not necessary, but BPS is more carefully treated in patients with impaired kidney function.
Improvement of functionality after chitosan-modified zein biocomposites

Abstract A series of chitosan-modified zein composite films were fabricated from zein and chitosan by a process involving blending, solution casting and evaporation. Effects of chitosan content on the structure and physical properties of the composite films were investigated by Fourier transform infrared spectroscopy, differential scanning calorimetry, scanning electron microscopy, tensile testing, water absorption measurement and water contact angle measurement. The results showed that the zein/chitosan composite films were fabricated successfully due to the formation of hydrogen bonds between zein and chitosan, and the thermal stability, water absorption, hydrophilicity, tensile strength, flexibility of the composite films increased with an increase in chitosan content from 0 to 50%. The cytotoxicity and cytocompatibility of the composite films were evaluated by 3-[45-dimethyl-2-thiazoly1]-25-diphenyl-2H-tetrazolium bromide (MTT) assay and in vitro cell culture, which showed that the films have non- or low-cytotoxicity, and chitosan promoted the growth, adhesion and proliferation of the cells. These results indicated that chitosan-modified zein composite films might have potentials applications as biomaterials.
Environmental impacts of and material recovery from biodegradable waste

2 DECLARATION . 3 ACKNOWLEDGEMENTS . 3 TABLE OF CONTENTS. 4 INDEX OF TABLES . 8 INDEX OF FIGURES. 10 CHAPTER 1: INTRODUCTION. 12 1.1 BACKGROUND . 13 1.2 THE NEED FOR FOOD WASTE TREATMENT. 15 1.3 THESIS OBJECTIVES . 16 1.4 SCOPE OF THE THESIS. 17 CHAPTER 2: LEGISLATION AND WASTE STRATEGY. 18 2.1 LEGISLATIVE FRAMEWORK. 19 2.1.1 Waste definition . 19 2.1.2 Legislation and waste . 21 2.1.3 Legislation and organic waste. 22 2.2 BACKGROUND TO WASTE AND WASTE STRATEGY . 30 2.2.2 Waste strategy . 30 2.2.3 Biodegradable and organic waste. 34 2.3 SUMMARY. 36 CHAPTER 3: FOOD WASTE CHARACTERISATION AND MANAGEMENT OPTIONS . 37 3.
Multistage multiphase switched‐capacitor DC–DC converter with variable‐phase and PWM control

A closed‐loop multistage multiphase switched‐capacitor converter (n‐stage p‐phase MPSC) is proposed with a variable‐phase control (VPC) and a pulse‐width‐modulation (PWM) technique for low‐power step‐up conversion and high‐efficiency regulation. In this n‐stage MPSC, n voltage doublers are connected in series for boosting the voltage gain up to 2n at most. Here, VPC is suggested to realize a variable multiphase operation by changing the phase number p and topological path for the more suitable level of voltage gain so as to improve the power efficiency, especially for the lower output voltage Besides, PWM is adopted not only to enhance output regulation for different desired outputs, but also to reinforce output robustness to source/loading variation. Further, some theoretical analyses and designs include: n‐stage p‐phase MPSC model, steady‐state analysis, conversion ratio, power efficiency, output ripple, stability, capacitance selection, and control design. Finally, the closed‐loop MPSC is simulated, and the hardware is implemented and tested. All the results are illustrated to show the efficacy of the proposed scheme. Copyright © 2011 John Wiley & Sons, Ltd.
Models of Driver Acceleration Behavior Prior to Real-World Intersection Crashes

Drivers involved in intersection collisions are at high risk of serious or fatal injury. Intersection advanced driver assistance systems (I-ADAS) are emerging active safety systems designed to help drivers safely traverse intersections. The effectiveness of I-ADAS is expected to be greatly dependent on pre-crash vehicle acceleration during intersection traversals. The objective of this paper was to develop pre-crash acceleration models for non-turning drivers involved in straight crossing path crashes and left-turning drivers in left turn across path opposite direction and lateral direction crashes. This paper used 348 event data recorder pre-crash records taken from crashes investigated as part of the National Automotive Sampling System/Crashworthiness Data System. The acceleration models generated from this pre-crash data were evaluated using a leave-one-out cross-validation procedure. Previously developed non-crash models from the literature were compared with the pre-crash models. Our hypothesis was that drivers involved in crashes would accelerate more aggressively than the “typical” driving population. This result suggests that drivers in pre-crash scenarios tend to accelerate more aggressively than drivers in normal scenarios (p<0.001). This has important implications for the design of I-ADAS. Specifically, higher acceleration results in less available time for I-ADAS to detect and respond to an imminent collision.
Real-time hand gesture recognition based on feature points extraction

Tracking moving objects is an area increasingly known in computer vision field. It plays a very important role in human-computer interaction. In this context we have developed a hand tracking and gesture recognition system that allows interaction with the machine in an intuitive and natural way. To ensure the tracking we apply the Kalman filter and detect the optimal points of the hand in order to determine the gesture expressed by user.
Neuroplastic changes in patients with schizophrenia undergoing cognitive remediation: triple-blind trial.

BackgroundPatients with schizophrenia have shown cognitive improvements following cognitive remediation, but the neuroplastic changes that support these processes are not fully understood.AimsTo use a triple-blind, placebo-controlled trial to examine neural activation before and after cognitive remediation or a computer skills training (CST) placebo (trial registration: NCT00995553)). MethodTwenty-seven participants underwent functional magnetic resonance imaging before and after being randomised to either cognitive remediation intervention or CST. Participants completed two variants of the N-back task during scanning and were assessed on measures of cognition, functional capacity, community functioning and symptoms.ResultsWe observed a group × time interaction in the left prefrontal cortex, wherein the cognitive remediation group showed increased activation. These changes correlated with improved task accuracy within the cognitive remediation group, whereas there was no relationship between changes in activation in untrained cognitive measures. Significant changes were not observed in other hypothesised areas for the cognitive remediation group.ConclusionsWe replicated the finding that cognitive remediation increases left lateral prefrontal activation during a working memory task in patients with schizophrenia, suggesting this may be an important neural target for these types of interventions.
On the Capacity of Wireless Powered Cognitive Relay Network with Interference Alignment

In this paper, a two-hop decode-and-forward cognitive radio system with deployed interference alignment is considered. The relay node is energy- constrained and scavenges the energy from the interference signals. In the literature, there are two main energy harvesting protocols, namely, time-switching relaying and power-splitting relaying. We first demonstrate how to design the beamforming matrices for the considered primary and secondary networks. Then, the system capacity under perfect and imperfect channel state information scenarios, considering different portions of time-switching and power-splitting protocols, is estimated.
Role of Human-Mediated Dispersal in the Spread of the Pinewood Nematode in China

Background Intensification of world trade is responsible for an increase in the number of alien species introductions. Human-mediated dispersal promotes not only introductions but also expansion of the species distribution via long-distance dispersal. Thus, understanding the role of anthropogenic pathways in the spread of invading species has become one of the most important challenges nowadays. Methodology/Principal Findings We analysed the invasion pattern of the pinewood nematode in China based on invasion data from 1982 to 2005 and monitoring data on 7 locations over 15 years. Short distance spread mediated by long-horned beetles was estimated at 7.5 km per year. Infested sites located further away represented more than 90% of observations and the mean long distance spread was estimated at 111–339 km. Railways, river ports, and lakes had significant effects on the spread pattern. Human population density levels explained 87% of the variation in the invasion probability (P<0.05). Since 2001, the number of new records of the nematode was multiplied by a factor of 5 and the spread distance by a factor of 2. We combined a diffusion model to describe the short distance spread with a stochastic, individual based model to describe the long distance jumps. This combined model generated an error of only 13% when used to predict the presence of the nematode. Under two climate scenarios (stable climate or moderate warming), projections of the invasion probability suggest that this pest could expand its distribution 40–55% by 2025. Conclusions/Significance This study provides evidence that human-induced dispersal plays a fundamental role in the spread of the pinewood nematode, and appropriate control measures should be taken to stop or slow its expansion. This model can be applied to Europe, where the nematode had been introduced later, and is currently expanding its distribution. Similar models could also be derived for other species that could be accidentally transported by humans.
Virtual Reality for Management of Pain in Hospitalized Patients: Results of a Controlled Trial

Background Improvements in software and design and reduction in cost have made virtual reality (VR) a practical tool for immersive, three-dimensional (3D), multisensory experiences that distract patients from painful stimuli. Objective The objective of the study was to measure the impact of a onetime 3D VR intervention versus a two-dimensional (2D) distraction video for pain in hospitalized patients. Methods We conducted a comparative cohort study in a large, urban teaching hospital in medical inpatients with an average pain score of ≥3/10 from any cause. Patients with nausea, vomiting, dementia, motion sickness, stroke, seizure, and epilepsy and those placed in isolation were excluded. Patients in the intervention cohort viewed a 3D VR experience designed to reduce pain using the Samsung Gear Oculus VR headset; control patients viewed a high-definition, 2D nature video on a 14-inch bedside screen. Pre- and postintervention pain scores were recorded. Difference-in-difference scores and the proportion achieving a half standard deviation pain response were compared between groups. Results There were 50 subjects per cohort (N=100). The mean pain reduction in the VR cohort was greater than in controls (−1.3 vs −0.6 points, respectively; P=.008). A total of 35 (65%) patients in the VR cohort achieved a pain response versus 40% of controls (P=.01; number needed to treat=4). No adverse events were reported from VR. Conclusions Use of VR in hospitalized patients significantly reduces pain versus a control distraction condition. These results indicate that VR is an effective and safe adjunctive therapy for pain management in the acute inpatient setting; future randomized trials should confirm benefit with different visualizations and exposure periods. Trial Registration Clinicaltrials.gov NCT02456987; https://clinicaltrials.gov/ct2/show/NCT02456987 (Archived by WebCite at http://www.webcitation.org/6pJ1P644S)
Variations on a nucleosome theme: The structural basis of centromere function

The centromere is a specialized chromosomal structure that dictates kinetochore assembly and, thus, is essential for accurate chromosome segregation. Centromere identity is determined epigenetically by the presence of a centromere-specific histone H3 variant, CENP-A, that replaces canonical H3 in centromeric chromatin. Here, we discuss recent work by Roulland et al. that identifies structural elements of the nucleosome as essential determinants of centromere function. In particular, CENP-A nucleosomes have flexible DNA ends due to the short αN helix of CENP-A. The higher flexibility of the DNA ends of centromeric nucleosomes impairs binding of linker histones H1, while it facilitates binding of other essential centromeric proteins, such as CENP-C, and is required for mitotic fidelity. This work extends previous observations indicating that the differential structural properties of CENP-A nucleosomes are on the basis of its contribution to centromere identity and function. Here, we discuss the implications of this work and the questions arising from it.
Effects of Antiepileptic Drugs on the Carotid Artery Intima-Media Thickness in Epileptic Patients

Background and Purpose It has been reported that taking antiepileptic drugs (AEDs) may increase the risk of atherosclerosis. We performed a meta-analysis to evaluate the carotid artery intima-media thickness (CA-IMT) as a surrogate factor for atherosclerosis in epileptic patients. Methods We searched NCBI (PubMed), ISI Web of Knowledge, EMBASE, and the Cochrane Library databases for studies of the association between AEDs and CA-IMT in epileptic patients. A random-effects meta-analysis was used to pool results across studies. Results Fifteen studies involving 1,775 epileptic patients were included in the analysis. The overall CA-IMT was significantly larger among users of AEDs [mean difference (MD)=0.09 mm, 95% confidence interval (CI)=0.06–0.12 mm). When stratified by age, the MD was similar in adult patients (MD=0.09 mm, 95% CI=0.06–0.13 mm), but no significant difference was observed in children (MD=0.03 mm, 95% CI=0.00–0.07 mm). Regarding specific AEDs, monotherapy with carbamazepine (CBZ) or valproic acid (VPA) was associated with a larger CA-IMT, while phenytoin monotherapy was not and the result for lamotrigine was inconclusive. Conclusions This study suggests that using AEDs is associated with the CA-IMT in patients with epilepsy, particularly for adult patients. In particular, CBZ and VPA may be related to a significant increase in CA-IMT.
Effects of Paper Mill Sludge on Potassium, Sodium, Calcium, and Magnesium Concentrations in Different Soybean Cultivars

A field experiment was conducted on a sandy loam soil at an Experimental Farm in Taejon, South Korea, to determine the effects of paper mill sludge compost application rates on K, Na, Ca and Mg concentrations of soybean (Glycine max (L.) Merr. ) aboveground tissues and the genotypic effects on the concentrations of these elements. Sludge compost treatments of 0, 75, and 150 t ha-1 were applied to 30 diverse soybean cultivars. Concentrations of K, Na, Ca, and Mg in aboveground tissues harvested 69 days after planting (DAP) varied with the genotype and the application rate of paper-mill sludge compost, with the sludge compost application rate exerting stronger influence on these concentrations than the genotype. The magnitude of variation caused by both genotype and sludge compost application was in the order of Mg K Ca Na. Significantly positive correlations were observed between K and Na (P 0.01), Na and Ca (P 0.05), and Ca and Mg (P 0.01). Also, the lower the sludge compost application rate, the larger the variation in the concentrations of K, Na, and Ca. From this several cultivars were identified for use as an accumulator for one or more of these elements.
Sleep hygiene education as a treatment of insomnia: a systematic review and meta-analysis

Background Sleep hygiene education (SHE) is commonly used as a treatment of insomnia in general practice. Whether SHE or cognitive-behavioural therapy for insomnia (CBT-I), a treatment with stronger evidence base, should be provided first remains unclear. Objective To review the efficacy of SHE for poor sleep or insomnia. Methods We systematically searched six key electronic databases up until May 2017. Two researchers independently selected relevant publications, extracted data and evaluated methodological quality according to the Cochrane criteria. Results Twelve of 15 studies compared SHE with CBT-I, three with mindfulness-based therapy, but none with sham or no treatment. General knowledge about sleep, substance use, regular exercise and bedroom arrangement were commonly covered; sleep-wake regularity and avoidance of daytime naps in seven programs, but stress management in only five programs. Major findings include (i) there were significant pre- to post-treatment improvements following SHE, with small to medium effect size; (ii) SHE was significantly less efficacious than CBT-I, with difference in effect size ranging from medium to large; (iii) pre- to post-treatment improvement and SHE-CBT-I difference averaged at 5% and 8% in sleep-diary-derived sleep efficiency, respectively, and two points in Pittsburgh Sleep Quality Index; (iv) only subjective measures were significant and (v) no data on acceptability, adherence, understanding and cost-effectiveness. Conclusions Although SHE is less effective than CBT-I, unanswered methodological and implementation issues prevent a firm conclusion to be made on whether SHE has a role in a stepped-care model for insomnia in primary care.
Involvement of let-7 microRNA for the therapeutic effects of Rhenium-188-embedded liposomal nanoparticles on orthotopic human head and neck cancer model

Human head and neck squamous cell carcinoma (HNSCC) is usually treated by surgical resection with adjuvant radio-chemotherapy. In this study, we examined whether the radiopharmaceutical 188Re-liposome could suppress the growth of HNSCC followed by an investigation of molecular mechanisms. The orthotopic HNSCC tumor model was established by human hypopharyngeal FaDu carcinoma cells harboring multiple reporter genes. The drug targeting and therapeutic efficacy of 188Re-liposome were examined using in vivo imaging, bio-distribution, pharmacokinetics, and dosimetry. The results showed that 188Re-liposome significantly accumulated in the tumor lesion compared to free 188Re. The circulation time and tumor targeting of 188Re-liposome were also longer than that of free 188Re in tumor-bearing mice. The tumor growth was suppressed by 188Re-liposome up to three weeks using a single dose treatment. Subsequently, microarray analysis followed by Ingenuity Pathway Analysis (IPA) showed that tumor suppressor let-7 microRNA could be an upstream regulator induced by 188Re-liposome to regulate downstream genes. Additionally, inhibition of let-7i could reduce the effects of 188Re-liposome on suppression of tumor growth, suggesting that let-7 family was involved in 188Re-liposome mediated suppression of tumor growth in vivo. Our data suggest that 188Re-liposome could be a novel strategy for targeting HNSCC partially via induction of let-7 microRNA.
Antiinflammatory and ROS Suppressive Effects of the Addition of Fiber to a High-Fat High-Calorie Meal

Background Fiber intake is associated with a reduction in the occurrence of cardiovascular events and diabetes. Objective To investigate whether the addition of fiber to a high-fat, high-calorie (HFHC) meal prevents proinflammatory changes induced by the HFHC meal. Design Ten normal fasting subjects consumed an HFHC meal with or without an additional 30 g of insoluble dietary fiber on 2 separate visits. Blood samples were collected over 5 hours, and mononuclear cells (MNCs) were isolated. Results Fiber addition to the HFHC meal significantly lowered glucose excursion in the first 90 minutes and increased insulin and C-peptide secretion throughout the 5-hour follow-up period compared with the meal alone. The HFHC meal induced increases in lipopolysaccharide (LPS) concentrations, MNC reactive oxygen species generation, and the expression of interleukin (IL)-1β, tumor necrosis factor α (TNF-α), Toll-like receptor (TLR)-4, and CD14. The addition of fiber prevented an increase in LPS and significantly reduced the increases in ROS generation and the expression of IL-1β, TNF-α, TLR-4, and CD14. In addition, the meal increased Suppressor of cytokine signaling (SOCS)-3 and protein tyrosine phosphatase 1B (PTP-1B) messenger RNA and protein levels, which were inhibited when fiber was added. Conclusions The addition of fiber to a proinflammatory HFHC meal had beneficial anti-inflammatory and metabolic effects. Thus, the fiber content of the American Heart Association meal may contribute to its noninflammatory nature. If these actions of dietary fiber are sustained following long-term intake, they may contribute to fiber's known benefits in the prevention of insulin resistance, type 2 diabetes, and atherosclerosis.