Miracle-dz/UniFAR-FTUs huggingface dataset:
Extracorporeal Membrane Oxygenation to Aid Cardiopulmonary Resuscitation in Infants and Children

Background— Extracorporeal membrane oxygenation (ECMO) has been used to support cardiorespiratory function during pediatric cardiopulmonary resuscitation (CPR). We report on outcomes and predictors of in-hospital mortality after ECMO used to support CPR (E-CPR). Methods and Results— Outcomes for patients aged <18 years using E-CPR were analyzed with data from the Extracorporeal Life Support Organization, and predictors of in-hospital mortality were determined. Of 26 242 ECMO uses reported, 695 (2.6%) were for E-CPR (n=682 patients). Survival to hospital discharge was 38%. In a multivariable model, pre-ECMO factors such as cardiac disease (odds ratio [OR] 0.51, 95% confidence interval [CI] 0.31 to 0.82) and neonatal respiratory disease (OR 0.28, 95% CI 0.12 to 0.66), white race (OR 0.65, 95% CI 0.45 to 0.94), and pre-ECMO arterial blood pH >7.17 (OR 0.50, 95% CI 0.30 to 0.84) were associated with decreased odds of mortality. During ECMO, renal dysfunction (OR 1.89, 95% CI 1.17 to 3.03), pulmonary hemorrhage (OR 2.23, 95% CI 1.11 to 4.50), neurological injury (OR 2.79, 95% CI 1.55 to 5.02), CPR during ECMO (OR 3.06, 95% CI 1.42 to 6.58), and arterial blood pH <7.2 (OR 2.23, 95% CI 1.23 to 4.06) were associated with increased odds of mortality. Conclusions— ECMO used to support CPR rescued one third of patients in whom death was otherwise certain. Patient diagnosis, absence of severe metabolic acidosis before ECMO support, and uncomplicated ECMO course were associated with improved survival.
Plasticity of HP1 proteins in mammalian cells

We have compared the distribution of endogenous heterochromatin protein 1 (HP1) proteins (α, β and γ) in different epithelial lines, pluripotent stem cells and embryonic fibroblasts. In parallel, we have interrogated assembly and dynamics of newly expressed HP1-GFP proteins in cells lacking both HP1α and HP1β alleles, blocked at the G1-S boundary, or cultured in the presence of HDAC and HAT inhibitors. The results reveal a range of cell type and differentiation state-specific patterns that do not correlate with `fast' or `slow' subunit exchange in heterochromatin. Furthermore, our observations show that targeting of HP1γ to heterochromatic sites depends on HP1α and H1β and that, on an architectural level, HP1α is the most polymorphic variant of the HP1 family. These data provide evidence for HP1 plasticity under shifting microenvironmental conditions and offer a new conceptual framework for understanding chromatin dynamics at the molecular level.
Development of a novel HAC-based “gain of signal” quantitative assay for measuring chromosome instability (CIN) in cancer cells

Accumulating data indicates that chromosome instability (CIN) common to cancer cells can be used as a target for cancer therapy. At present the rate of chromosome mis-segregation is quantified by laborious techniques such as coupling clonal cell analysis with karyotyping or fluorescence in situ hybridization (FISH). Recently, a novel assay was developed based on the loss of a non-essential human artificial chromosome (HAC) carrying a constitutively expressed EGFP transgene (“loss of signal” assay). Using this system, anticancer drugs can be easily ranked on by their effect on HAC loss. However, it is problematic to covert this “loss of signal” assay into a high-throughput screen to identify drugs and mutations that increase CIN levels. To address this point, we re-designed the HAC-based assay. In this new system, the HAC carries a constitutively expressed shRNA against the EGFP transgene integrated into human genome. Thus, cells that inherit the HAC display no green fluorescence, while cells lacking the HAC do. We verified the accuracy of this “gain of signal” assay by measuring the level of CIN induced by known antimitotic drugs and added to the list of previously ranked CIN inducing compounds, two newly characterized inhibitors of the centromere-associated protein CENP-E, PF-2771 and GSK923295 that exhibit the highest effect on chromosome instability measured to date. The “gain of signal” assay was also sensitive enough to detect increase of CIN after siRNA depletion of known genes controlling mitotic progression through distinct mechanisms. Hence this assay can be utilized in future experiments to uncover novel human CIN genes, which will provide novel insight into the pathogenesis of cancer. Also described is the possible conversion of this new assay into a high-throughput screen using a fluorescence microplate reader to characterize chemical libraries and identify new conditions that modulate CIN level.
Destabilization of DNA duplexes by oxidative damage at guanine: implications for lesion recognition and repair

We have used molecular dynamics simulations to study the structure and dynamics of a range of DNA duplexes containing the 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapydG) lesion that can result from oxidative damage at guanine. Compared to the corresponding undamaged DNA duplexes, FapydG-containing duplexes show little gross structural changes—the damaged base remains stacked in to the DNA double helix and retains hydrogen bonds to its cytosine partner. However, the experimentally observed reduction in DNA stability that accompanies lesion formation can be explained by a careful energetic analysis of the simulation data. Irrespective of the nature of the base pairs on either side of the lesion site, conversion of a guanine to a FapydG base results in increased dynamical flexibility in the base (but not in the DNA as a whole) that significantly weakens its hydrogen-bonding interactions. Surprisingly, the stacking interactions with its neighbours are not greatly altered. The formamido group adopts a non-planar conformation that can interact significantly and in a sequence-dependent manner with its 3′-neighbour. We conclude that the recognition of FapydG lesions by the repair protein formamidopyrimidine-DNA glycosylase probably does not involve the protein capturing an already-extrahelical FapydG base, but rather it relies on detecting alterations to the DNA structure and flexibility created by the lesion site.
Pseudorandom numbers generators quality assessment using graphic tests

In this paper we address testing methodologies of pseudorandom numbers generators (PRNGs) and propose improved approaches which increase testing efficiency. At present time, PRNG quality is usually assessed using two main groups of tests: evaluation tests and graphic tests. When executing an evaluation test on a pseudorandom sequence, the assessment is based on computing specific statistics and its comparison to predefined critical values. Graphical tests are less common, however, in some cases, executing graphic tests allows detecting flaws in the PRNG's design which could be overlooked by common evaluation tests. In this paper, authors review some graphic tests implementations for PRNG statistical properties evaluation.
Epistemic Collaborations in Contexts of Change: On Conceptual Fieldwork and the Timing of Anthropological Knowledge

In order to examine the methodological potential of a more experimental form of fieldwork, I present three examples of conceptual interventions in my fieldsite, Hoyerswerda, Germany’s fastest shrinking city. My deployment of weekly anthropological columns in the local newspaper, an anthropological research camp for local youth, and a communal art project in a soon to be demolished socialist apartment house as ethnographic tools might be criticized for changing the field. However, my informants are themselves continuously adjusting their concepts and narratives in order to make sense of current rapid alterations. By actively intervening in local debates concerning the city, I have aimed to transform ethnographic interference from a necessary vice to a methodological virtue. Since my conceptual fieldwork was particularly helpful in studying epistemic change, I propose a reconsideration of the timing of anthropological knowledge, arguing for a more timely strategy of its representation “in the making” and an expanded facilitation of epistemic collaborations during fieldwork . In English, extended summary in Russian.
Haloprogin and nystatin therapy for cutaneous candidiasis. Comparison of the efficacy of haloprogin and nystatin therapy.

Sixty-eight patients with a clinical diagnosis of cutaneous candidiasis confirmed by a potassium hydroxide (KOH) examination and culture studies were treated with haloprogin cream or nystatin ointment in a double-blind study. Each of the drugs was applied for 13 consecutive days. The results of clinical observations, KOH examination, and culture studies showed that there was no significant difference in the efficacy of these two drugs in the treatment of cutaneous candidal infections. The cure rate for both products exceeded 80%. The efficacy of haloprogin in the treatment of dermatophytoses and candidiasis shows that it has a broad spectrum of antimicrobial activity, with no known toxicity or reported important adverse reactions when used in the approved dosages.
Reduced entropy parameterization of MIMO channel matrices for finite-rate feedback

By using perfect Channel State Information (CSI) at the transmitter significant gains in terms of sum rate can be obtained in the Multiple-Input Multiple-Output (MIMO) broadcast channel. In practice the links from the users to the transmitters allow only a limited amount of feedback for the CSI, which requires efficient compression schemes at the receivers. In this paper we consider the representation of Gaussian channel matrices by scalar parameters, which are quantized and fed back to the transmitter. This way also the numerically complex vector quantization can be avoided. A novel parameterization is presented which reduces the differential entropy of the parameters and improves the performance of the data transmission in the downlink compared to a state-of-the-art approach.
The Relationship Among Teaching Methods, Student Characteristics, and Student Involvement in Learning

Various classroom teaching methods have been termed &dquo;lesson formats&dquo; (Dunkin & Biddle, 1974) or, more simply, &dquo;teaching methods&dquo; (Berliner & Gage, 1976). The latter define teaching methods as &dquo;recurrent instructional processes, applicable to various subject matters, and usable by more than one teacher&dquo; (p. 5). Three commonly used teaching methods are lecture, discussion, and seatwork. Although teachers use a variety of these methods in their classes, they have received little help from theorists or researchers as to which method, or methods, best facilitates learning. Early research, mostly conducted at the postsecondary level, compared the effectiveness of any two teaching methods. Dubin and Taveggia (1968)’ reviewed 36 experimental studies on the most popular comparison between lecture and discussion methods. They found that 51 percent of the comparisons favored the lecture method, and 49 percent favored the discussion method. Virtually no overall difference in the effectiveness of the two methods was indicated.
In the Rhythm of the Global Market: Female Expatriates and Mobile Careers: A Case Study of Indian ICT Professionals on the Move

Drawing upon research regarding the complexities of family reunification migration and the migration of highly skilled individuals, this article outlines the experiences in mobility of highly skilled female professionals in the information and communication technology (ICT) sector. In turn, the focus lies on the impact of mobility on family life and how the family influences decision-making processes regarding transnational career trajectories. In migration studies, little attention has been given to family-linked migration among the highly skilled. This anthropological research contributes to filling this gap as the experiences and coping strategies of Indian ICT professionals and their accompanying spouses will be studied from their point of view. This article presents narrative biographical data on Indian ICT professionals, their dependants, and dual-career households, with or without children, who embarked on mobile career paths that led to Belgium. The data have been gathered through participant observation and in-depth, semistructured interviews, and were analysed in terms of exclusion and inclusion in a globalized knowledge economy. By looking at the intersection of female biographies and expatriation, this case study demonstrates the family dynamics in mobility decisions and the multidirectional characteristics of careers offered by the global ICT sector.
Automatic Detection of Research Interest Using Topic Modeling

We demonstrated the possibility of inferring the research interest of an MIT faculty member given the title of only a few research papers written by him or her, using a topic model learned from a corpus of research paper text not necessarily related to any faculty members of MIT, and a list of topic keywords such as that of the Library of Congress. The topic model was generated using a variant of Latent Dirichlet Allocation coupled with a pointwise mutual information analysis between topic keywords and latent topics. Thesis Supervisor: Regina Barzilay Title: Associate Professor
Evaluation of the Vitek 2 ANC Card for Identification of Clinical Isolates of Anaerobic Bacteria

ABSTRACT An evaluation of the Vitek 2 ANC card (bioMérieux, Marcy l'Etoile, France) was performed with 301 anaerobic isolates. Each strain was identified by 16S rRNA gene sequencing, which is considered to be the reference method. The Vitek 2 ANC card correctly identified 239 (79.4%) of the 301 clinical isolates to the genus level, including 100 species that were not represented in the database. Correct species identification was obtained for 60.1% (181/301) of the clinical isolates. For the isolates not identified to the species level, a correct genus identification was obtained for 47.0% of them (47/100), and 16 were accurately designated not identified. Although the Vitek 2 ANC card allows the rapid and acceptable identification of the most common clinically important anaerobic bacteria within 6 h, improvement is required for the identification of members of the genera Fusobacterium, Prevotella, and Actinomyces and certain Gram-positive anaerobic cocci (GPAC).
CONTENT‐ORIENTED PERSONNEL SELECTION IN A SMALL BUSINESS SETTING

This paper illustrates a content-oriented procedure for personnel selection in a small business setting. The procedure focuses directly on criterion performance, inasmuch as it generates lists of tasks relevant to specific job objectives. Rank order correlations provide quantitative indices of agreement between members of the job analysis panel as to the relative importance of the job objectives. The importance of appropriate representation on the job analysis panel is emphasized.
Intelligent Java Analyzer

This paper presents a software metric working prototype to evaluate Java programmer's profiles. In order to automatically detect source code patterns, a Multi Layer Perceptron neural network is applied. Features determined from such patterns constitute the basis for systempsilas programmer profiling. Results presented here show that the proposed prototype is a confident approach for support in the software quality assurance process.
Open Trial and Pilot Randomized Controlled Trial of a Novel Program to Reduce Perceived Burdensomeness

We have read this dissertation and recommend that it be approved. iv ACKNOWLEDGMENTS To the mentors who have provided guidance and support, the instructors who have opened doors and showed me new possibilities, and to the friends and colleagues who have encouraged, put up with, and artfully distracted me: You each have my profound thanks. This work would not have been possible, first and foremost, without the support of my faculty advisor, Dr. Jeremy Pettit, my dissertation committee members, and the faculty who have provided support, both formal and informal, along the way. Nor would this work have been completed without the assistance of my fellow graduate students and a dedicated team of research assistants. To date, suicide prevention programs for adolescents have not demonstrated sustained reductions in suicide-related behaviors and further program development is called for, particularly for the prevention of non-clinical suicide risk. This research utilizes the Interpersonal-Psychological Theory of Suicide in the development of the LEAP Program, a novel, web-based suicide prevention program targeting reductions in cognitions of perceived burdensomeness. An open trial of the program was conducted to examine the feasibility of the study protocol, generate feedback regarding the LEAP program modules, and refine the program modules. A pilot randomized controlled trial of the program was also conducted to examine participant satisfaction with the intervention and adherence to the intervention protocol, to test the research protocol, and to provide initial evidence for its efficacy. The open trial consisted of eight adolescents who completed a baseline assessment, received the LEAP intervention, and completed a post-intervention assessment. Results indicated sufficient feasibility of the study protocol and acceptability of the LEAP intervention. The pilot randomized controlled trial consisted of 80 adolescents who were randomly assigned to either the LEAP intervention or a treatment-vi as-usual control condition. Results indicated that those who completed the LEAP intervention showed significantly reduced perceived burdensomeness scores at post-intervention, as compared to those in the control condition. In addition, those who completed the intervention reported significantly reduced perceived burdensomeness, thwarted belongingness, and depressive symptom scores at follow-up, as compared to those in the control condition. No significant reductions in suicidal ideation were noted for those who completed the intervention, as compared to those in the control condition. Strengths and weaknesses of the present studies are discussed, and considerations for future research directions are noted.
In-band cellular IoT for smart home applications

Smart home and its applications are one of the main interests of IoT (internet of things). Recently, 3GPP has introduced cellular IoT systems including LTE-M and NB-IoT (narrowband IoT). In this letter, we propose a unified frame structure for providing the applications of cellular IoTs to smart home scenario and implement using the USRP-RIO. The experimental results verify the performances of cellular IoTs in smart home environments.
Atrial tachyarrhythmias and cardiac resynchronisation therapy: clinical and therapeutic implications

Atrial fibrillation (AF) represents one of the most important comorbidities in patients with heart failure (HF). This report highlights the available evidence for the relationship between AF and cardiac resynchronisation therapy (CRT). Studies on the use of CRT in patients with HF and AF have demonstrated its effectiveness. It seems to reduce the AF burden and determines left atrial reverse remodelling. No definite data are available on AF ablation in patients with CRT but it might represent a therapeutic option. Furthermore, modern implantable pacemakers and cardioverter-defibrillators are provided with diagnostic algorithms which allow a better understanding of the AF burden.
Recapitulating X-Linked Juvenile Retinoschisis in Mouse Model by Knock-In Patient-Specific Novel Mutation

X-linked juvenile retinoschisis (XLRS) is a retinal disease caused by mutations in the gene encoding retinoschisin (RS1), which leads to a significant proportion of visual impairment and blindness. To develop personalized genome editing based gene therapy, knock-in animal disease models that have the exact mutation identified in the patients is extremely crucial, and that the way which genome editing in knock-in animals could be easily transferred to the patients. Here we recruited a family diagnosed with XLRS and identified the causative mutation (RS1, p.Y65X), then a knock-in mouse model harboring this disease-causative mutation was generated via TALEN (transcription activator-like effector nucleases). We found that the b-wave amplitude of the ERG of the RS1-KI mice was significantly decreased. Moreover, we observed that the structure of retina in RS1-KI mice has become disordered, including the disarray of inner nuclear layer and outer nuclear layer, chaos of outer plexiform layer, decreased inner segments of photoreceptor and the loss of outer segments. The novel knock-in mice (RS1-KI) harboring patient-specific mutation will be valuable for development of treatment via genome editing mediated gene correction.
Intravascular lymphoma: magnetic resonance imaging correlates of disease dynamics within the central nervous system

Background: Intravascular lymphoma (IVL) is a rare non-Hodgkin’s lymphoma with relative predilection for the central nervous system. In the absence of extraneural manifestations, the disease is not recognised until autopsy in the majority of cases underlining the need for new clinical markers. Methods: This is a retrospective series of five patients with IVL seen at a single institution over three years. An advanced magnetic resonance imaging (MRI) protocol was performed at various time points prior to diagnosis and during treatment. Results: MRI revealed multiple lesions scattered throughout the cerebral hemispheres; the brainstem, cerebellum, and spinal cord were less frequently involved. On initial presentation, hyperintense lesions were seen on diffusion weighted images suggestive of ischaemia in three of four patients in whom the images were obtained at that time point. In four patients lesions were also identifiable as hyperintense areas on fluid attenuated inversion recovery (FLAIR) sequences. Initial contrast enhancement was encountered in three cases. Diffusion weighted imaging lesions either vanished or followed the typical pattern of an ischaemic small vessel stroke with evolution of abnormal FLAIR signal followed by enhancement with gadolinium in the subacute stage and tissue loss in the chronic stage. Diffusion weighted imaging and FLAIR abnormalities proved to be partially reversible, correlating with the response to chemotherapy. Conclusion: We provide the first detailed description of the dynamic pattern of diffusion weighted MRI in IVL. These patterns in combination with systemic findings may facilitate early diagnosis and serve as a new tool to monitor treatment response.
Theoretical investigation of back gate bias effect on the electrostatic integrity of Insulated Shallow Extension Silicon On Void (ISESOV) MOSFET

The present work discusses the electrostatic integrity of Insulated Shallow Extension Silicon On Void (ISESOV) MOSFET examine by calculating the 2D potential in the channel region using Poisson's equation. The complete drain current model incorporating velocity overshoot effect and the Channel Length Modulation effect (CLM) has also been developed for channel length down to 32nm. Furthermore, the impact of back gate bias voltage (forward and reverse both) on the sub-threshold performance, drain current and inverter performance has also been studied.