Miracle-dz/UniFAR-FTUs huggingface dataset:
Human neural stem cells promote proliferation of endogenous neural stem cells and enhance angiogenesis in ischemic rat brain

Transplantation of human neural stem cells into the dentate gyrus or ventricle of rodents has been reportedly to enhance neurogenesis. In this study, we examined endogenous stem cell proliferation and angiogenesis in the ischemic rat brain after the transplantation of human neural stem cells. Focal cerebral ischemia in the rat brain was induced by middle cerebral artery occlusion. Human neural stem cells were transplanted into the subventricular zone. The behavioral performance of human neural stem cells-treated ischemic rats was significantly improved and cerebral infarct volumes were reduced compared to those in untreated animals. Numerous transplanted human neural stem cells were alive and preferentially localized to the ipsilateral ischemic hemisphere. Furthermore, 5-bromo-2′-deoxyuridine-labeled endogenous neural stem cells were observed in the subventricular zone and hippocampus, where they differentiated into cells immunoreactive for the neural markers doublecortin, neuronal nuclear antigen NeuN, and astrocyte marker glial fibrillary acidic protein in human neural stem cells-treated rats, but not in the untreated ischemic animals. The number of 5-bromo-2′-deoxyuridine-positive ⁄ anti-von Willebrand factor-positive proliferating endothelial cells was higher in the ischemic boundary zone of human neural stem cells-treated rats than in controls. Finally, transplantation of human neural stem cells in the brains of rats with focal cerebral ischemia promoted the proliferation of endogenous neural stem cells and their differentiation into mature neural-like cells, and enhanced angiogenesis. This study provides valuable insights into the effect of human neural stem cell transplantation on focal cerebral ischemia, which can be applied to the development of an effective therapy for stroke.
Multi-objective distributed run-time resource management for many-cores

Dynamic usage scenarios of many-core systems require sophisticated run-time resource management that can deal with multiple often conflicting application and system objectives. This paper proposes an approach based on nonlinear programming techniques that is able to trade off between objectives while respecting targets regarding their values. We propose a distributed application embedding for dealing with soft system-wide constraints as well as a centralized one for strict constraints. The experiments show that both approaches may significantly outperform related heuristics.
Efficient subgraph search over large uncertain graphs

Retrieving graphs containing a query graph from a large graph database is a key task in many graph-based applications, including chemical compounds discovery, protein complex prediction, and structural pattern recognition. However, graph data handled by these applications is often noisy, incomplete, and inaccurate because of the way the data is produced. In this paper, we study subgraph queries over uncertain graphs. Specifically, we consider the problem of answering threshold-based probabilistic queries over a large uncertain graph database with the possible world semantics. We prove that problem is #P-complete, therefore, we adopt a filtering-and-verification strategy to speed up the search. In the filtering phase, we use a probabilistic inverted index, PIndex, based on subgraph features obtained by an optimal feature selection process. During the verification phase, we develop exact and bound algorithms to validate the remaining candidates. Extensive experimental results demonstrate the effectiveness of the proposed algorithms.
Errors in clinical laboratories or errors in laboratory medicine?

Abstract Laboratory testing is a highly complex process and, although laboratory services are relatively safe, they are not as safe as they could or should be. Clinical laboratories have long focused their attention on quality control methods and quality assessment programs dealing with analytical aspects of testing. However, a growing body of evidence accumulated in recent decades demonstrates that quality in clinical laboratories cannot be assured by merely focusing on purely analytical aspects. The more recent surveys on errors in laboratory medicine conclude that in the delivery of laboratory testing, mistakes occur more frequently before (pre-analytical) and after (post-analytical) the test has been performed. Most errors are due to pre-analytical factors (46–68.2% of total errors), while a high error rate (18.5–47% of total errors) has also been found in the post-analytical phase. Errors due to analytical problems have been significantly reduced over time, but there is evidence that, particularly for immunoassays, interference may have a serious impact on patients. A description of the most frequent and risky pre-, intra- and post-analytical errors and advice on practical steps for measuring and reducing the risk of errors is therefore given in the present paper. Many mistakes in the Total Testing Process are called “laboratory errors”, although these may be due to poor communication, action taken by others involved in the testing process (e.g., physicians, nurses and phlebotomists), or poorly designed processes, all of which are beyond the laboratory's control. Likewise, there is evidence that laboratory information is only partially utilized. A recent document from the International Organization for Standardization (ISO) recommends a new, broader definition of the term “laboratory error” and a classification of errors according to different criteria. In a modern approach to total quality, centered on patients' needs and satisfaction, the risk of errors and mistakes in pre- and post-examination steps must be minimized to guarantee the total quality of laboratory services.
Motor competence and goal setting in rugby

The study explored the potential of rugby as a developmental experience, not only in terms of the motor skills that lead to competence in rugby, but also in terms of learning more about the life-skill of goal setting. A 10 session pre-season programme entitled “More than Rugby” was designed and implemented in order to determine whether combining skill instruction with activities specifically designed to increase an understanding of goal setting had an impact on either the development of rugby competence or understanding about goal setting and perceptions of its use. A repeated measures experimental design was followed, with two groups of high school rugby players from similar sporting backgrounds involved: An experimental group who received pre-season rugby training as well as an intervention programme dealing with goal setting, and a control group who received only the pre-season rugby training, but no special goal setting activities. Both groups were pre tested and post tested on their rugby competence (through an individual rugby skill test circuit) and their understanding of goal setting The self reported use of goal setting perceptions, the relationship between goals and performance and the effects of goals on players was measured by means of a questionnaire (adapted GSI). The results revealed a significant improvement in the quality of rugby skills of the experimental group, but no significant improvement was found in the quality of the rugby skills of the control group. Both groups showed improvement in the speed at which rugby skills were performed, but in neither case was the improvement significant. The understanding of goal setting and the knowledge of setting goals did not improve significantly for either group. It can be concluded that the inclusion of life skills content and activities, such as goal setting in rugby development programmes will not detract from skill development outcomes. Although it can be noted that the greater improvement in skill levels was achieved by the group who received goal setting, more research is recommended to explain the positive link between life skills development and sport skills development.
Chemically Resolved Particle Fluxes Over Tropical and Temperate Forests

Chemically resolved submicron (PM1) particle mass fluxes were measured by eddy covariance with a high resolution time-of-flight aerosol mass spectrometer over temperate and tropical forests during the BEARPEX-07 and AMAZE-08 campaigns. Fluxes during AMAZE-08 were small and close to the detection limit (<1 ng m−2 s−1) due to low particle mass concentrations (<1 μg m−3). During BEARPEX-07, concentrations were five times larger, with mean mid-day deposition fluxes of −4.8 ng m−2 s−1 for total nonrefractory PM1 (Vex,PM1 = −1 mm s−1) and emission fluxes of +2.6 ng m−2 s−1 for organic PM1 (Vex,org = +1 mm s−1). Biosphere–atmosphere fluxes of different chemical components are affected by in-canopy chemistry, vertical gradients in gas-particle partitioning due to canopy temperature gradients, emission of primary biological aerosol particles, and wet and dry deposition. As a result of these competing processes, individual chemical components had fluxes of varying magnitude and direction during both campaigns. Oxygenated organic components representing regionally aged aerosol deposited, while components of fresh secondary organic aerosol (SOA) emitted. During BEARPEX-07, rapid in-canopy oxidation caused rapid SOA growth on the timescale of biosphere-atmosphere exchange. In-canopy SOA mass yields were 0.5–4%. During AMAZE-08, the net organic aerosol flux was influenced by deposition, in-canopy SOA formation, and thermal shifts in gas-particle partitioning. Wet deposition was estimated to be an order of magnitude larger than dry deposition during AMAZE-08. Small shifts in organic aerosol concentrations from anthropogenic sources such as urban pollution or biomass burning alters the balance between flux terms. The semivolatile nature of the Amazonian organic aerosol suggests a feedback in which warmer temperatures will partition SOA to the gas-phase, reducing their light scattering and thus potential to cool the region. Copyright 2013 American Association for Aerosol Research
Cooperative Role of Mineralocorticoid Receptor and Caveolin-1 in Regulating the Vascular Response to Low Nitric Oxide–High Angiotensin II–Induced Cardiovascular Injury

Aldosterone interacts with mineralocorticoid receptor (MR) to stimulate sodium reabsorption in renal tubules and may also affect the vasculature. Caveolin-1 (cav-1), an anchoring protein in plasmalemmal caveolae, binds steroid receptors and also endothelial nitric oxide synthase, thus limiting its translocation and activation. To test for potential MR/cav-1 interaction in the vasculature, we investigated if MR blockade in cav-1–replete or –deficient states would alter vascular function in a mouse model of low nitric oxide (NO)–high angiotensin II (AngII)–induced cardiovascular injury. Wild-type (WT) and cav-1 knockout mice (cav-1−/−) consuming a high salt diet (4% NaCl) received Nω-nitro-l-arginine methyl ester (L-NAME) (0.1–0.2 mg/ml in drinking water at days 1–11) plus AngII (0.7–2.8 mg/kg per day via an osmotic minipump at days 8–11) ± MR antagonist eplerenone (EPL) 100 mg/kg per day in food. In both genotypes, blood pressure increased with L-NAME + AngII. EPL minimally changed blood pressure, although its dose was sufficient to block MR and reverse cardiac expression of the injury markers cluster of differentiation 68 and plasminogen activator inhibitor-1 in L-NAME+AngII treated mice. In aortic rings, phenylephrine and KCl contraction was enhanced with EPL in L-NAME+AngII treated WT mice, but not cav-1−/− mice. AngII-induced contraction was not different, and angiotensin type 1 receptor expression was reduced in L-NAME + AngII treated WT and cav-1−/− mice. In WT mice, acetylcholine-induced relaxation was enhanced with L-NAME + AngII treatment and reversed with EPL. Acetylcholine relaxation in cav-1−/− mice was greater than in WT mice, not modified by L-NAME + AngII or EPL, and blocked by ex vivo L-NAME, 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one (ODQ), or endothelium removal, suggesting the role of NO-cGMP. Cardiac endothelial NO synthase was increased in cav-1−/− versus WT mice, further increased with L-NAME + AngII, and not affected by EPL. Vascular relaxation to the NO donor sodium nitroprusside was increased with L-NAME + AngII in WT mice but not in cav-1−/− mice. Plasma aldosterone levels increased and cardiac MR expression decreased in L-NAME + AngII treated WT and cav-1−/− mice and did not change with EPL. Thus, during L-NAME + AngII induced hypertension, MR blockade increases contraction and alters vascular relaxation via NO-cGMP, and these changes are absent in cav-1 deficiency states. The data suggest a cooperative role of MR and cav-1 in regulating vascular contraction and NO-cGMP–mediated relaxation during low NO–high AngII–dependent cardiovascular injury.
Enhancing Software Dependability and Security with Hardware Supported Instruction Address Space Randomization

We present a micro-architecture based lightweight framework to enhance dependability and security of software against code reuse attack. Different from the prior hardware based approaches for mitigating code reuse attacks, our solution is based on software diversity and instruction level control flow randomization. Generally, software based instruction location randomization (ILR) using binary emulator as a mediation layer has been shown to be effective for thwarting code reuse attacks like return oriented programming (ROP). However, our in-depth studies show that straightforward and naive implementation of ILR at the micro-architecture level will incur major performance deficiencies in terms of instruction fetch and cache utilization. For example, straightforward implementation of ILR increases the first level instruction cache miss rates on average by more than 9 times for a set of SPEC CPU2006 benchmarks. To address these issues, we present a novel micro-architecture design that can support native execution of control flow randomized software binary while at the same time preserve the performance of instruction fetch and efficient use of on-chip caches. The proposed design is evaluated by extending cycle based x86 architecture simulator, XIOSim with validated power simulation. Performance evaluation on SPEC CPU2006 benchmarks shows an average speedup of 1.63 times compared to the hardware implementation of ILR. Using the proposed approach, direct execution of ILR software incurs only 2.1% IPC performance slowdown with a very small hardware overhead.
Should yield be a design objective?

The objectives of good chip design have traditionally included issues like performance, power and reliability. Yield is rarely considered during the design process, except in the design of memory ICs, where specific defect-tolerance techniques are incorporated into the architecture for yield enhancement. In order to make the case for establishing yield as another design objective we must first prove that a chip's yield cannot only be affected, but consistently improved, by decisions made during the design process.
Logo recognition and localization in real-world images by using visual patterns

By describing spatial relationships between feature points, we present promising logo recognition and localization, which are verified based on two state-of-the-art datasets. Given features points on the query logo, similar features on test images are efficiently found by locality sensitive hashing. After filtering out outliers, candidate regions are found by the mean-sift algorithm, and each region is compared with the logo by jointly considering visual word histogram and visual patterns. Evaluation results show that visual patterns more appropriately describe logos and provide better performance than previous approaches.
Total Artificial Heart and Chronic Haemodialysis: A Possible Bridge to Transplantation?

Background: Total artificial heart (TAH) device is sometimes necessary to treat end stage heart failure (HF). After surgery, renal impairment can occur with the need of renal replacement therapy. Method: We report the case of a 51-year-old man who was treated with conventional hemodialysis (HD) while on support with TAH. Results: The patient underwent HD while on TAH support during 14 months. He benefited from conventional HD, 6 sessions per week. HD sessions were well tolerated, and patient's condition and quality of life improved significantly. The main difficulty was to maintain red blood cell level because of chronic hemolysis due to TAH, which required repetitive blood transfusions, resulting in a high rate of human leukocyte antigen sensitization. Unfortunately, the patient died of mesenteric ischemia due to anticoagulation under dosing. Conclusion: We conclude that HD treatment is possible despite TAH and should be considered in patients with both end stage renal and HF.
Soziales Kapital und Arbeitslosigkeit

Zusammenfassung Der vorliegende Beitrag präsentiert eine empirisch vergleichende Analyse zur Wirkung des sozialen Kapitals auf den Schweizer Arbeitsmärkten und fragt, inwiefern die unterschiedlich hohen Arbeitslosenquoten in den Kantonen zwischen 1992 und 1997 auf die ungleiche Verteilung des Sozialkapitals zurückgeführt werden können. Der Grundgedanke dieses Konzeptes ist, dass sich Individuen oder Gruppen eine Reihe von Handlungsressourcen und -verpflichtungen aus eng vernetzten sozialen Verbindungen eröffnen. Mit Blick auf den Arbeitsmarkt wird die Hypothese verfolgt, dass ein hoher Grad an sozialem Kapital zur effizienten Nutzung des Informationspotentials verhilft, mithin anstehende Such- und Transaktionskosten reduziert, die Qualität von Stellenbewerbern sichert, die Problematik der Nichtkooperation zwischen In- und Outsidern mindert, die Suchaktivitäten der Erwerbslosen steigert und damit in der Summe die Zahl der Arbeitslosen begrenzt. Das zentrale Ergebnis der Arbeit ist, dass ungleiche Verteilungen von sozialem Kapital in den Kantonen - neben anderen ökonomischen und politischen Größen - zu einem erheblichen Teil die unterschiedliche Verwundbarkeit kantonaler Arbeitsmärkte in Bezug auf rezessionsbedingte Auswirkungen erklären.
Magic in the Air: Mobile Communication and the Transformation of Social Life

In this timely volume, James E. Katz, a leading authority on social consequences of communication technology, analyzes the way new mobile telecommunications affect daily life both in the United States and around the world. "Magic in the Air" is the most wide-ranging analysis of mobile communication to date. Katz investigates the spectrum of social aspects of the cell phone's impact on society and the way social forces affect the use, display and reconfiguration of the cell phone. Surveying the mobile phone's current and emerging role in daily life, Katz finds that it provides many benefits for the user, and that some of these benefits are subtle and even counter-intuitive. He also identifies ways the mobile phone has not been entirely positive. After reviewing these, he outlines some steps to ameliorate the mobile phone's negative effects. Katz also discusses use and abuse of mobile phones in educational settings, where he finds that mobile phone use is eroding students' participation in class even as it is helping them to cheat on exams and cut class. Parents no longer object to their children having mobile phones in class in a post-Columbine and 9/11 era; instead they are pressing schools to change their rules to allow students to have their phones available during class. And mobile phone misbehaviour is, by no means, limited to students: Katz finds that teachers are increasingly taking calls in the middle of class, even interrupting their own lectures to answer what they claim are important calls. In keeping with the book's title, Katz explores the often overlooked psychic and religious uses of the mobile phone, an area that has only recently begun to command scholarly interest. "Magic in the Air" will be essential reading for communications specialists, sociologists, and social psychologists.
Selective Stimulation of the Spinal Cord Surface Using a Stretchable Microelectrode Array

By electrically stimulating the spinal cord, it is possible to activate functional populations of neurons that modulate motor and sensory function. One method for accessing these neurons is via their associated axons, which project as functionally segregated longitudinal columns of white-matter funiculi (i.e., spinal tracts). To stimulate spinal tracts without penetrating the cord, we have recently developed technology that enables close-proximity, multi-electrode contact with the spinal cord surface. Our stretchable microelectrode arrays (sMEAs) are fabricated using an elastomer polydimethylsiloxane substrate and can be wrapped circumferentially around the spinal cord to optimize electrode contact. Here, sMEAs were used to stimulate the surfaces of rat spinal cords maintained in vitro, and their ability to selectively activate axonal surface tracts was compared to rigid bipolar tungsten microelectrodes pressed firmly onto the cord surface. Along dorsal column tracts, the axonal response to sMEA stimulation was compared to that evoked by rigid microelectrodes through measurement of their evoked axonal compound action potentials (CAPs). Paired t-tests failed to reveal significant differences between the sMEA’s and the rigid microelectrode’s stimulus resolution, or in their ranges of evoked CAP conduction velocities. Additionally, dual-site stimulation using sMEA electrodes recruited spatially distinct populations of spinal axons. Site-specific stimulation of the ventrolateral funiculus – a tract capable of evoking locomotor-like activity – recruited ventral root efferent activity that spanned several spinal segments. These findings indicate that the sMEA stimulates the spinal cord surface with selectivity similar to that of rigid microelectrodes, while possessing potential advantages concerning circumferential contact and mechanical compatibility with the cord surface.
Semidominant suppressors of Srs2 helicase mutations of Saccharomyces cerevisiae map in the RAD51 gene, whose sequence predicts a protein with similarities to procaryotic RecA proteins

Eleven suppressors of the radiation sensitivity of Saccharomyces cerevisiae diploids lacking the Srs2 helicase were analyzed and found to contain codominant mutations in the RAD51 gene known to be involved in recombinational repair and in genetic recombination. These mutant alleles confer an almost complete block in recombinational repair, as does deletion of RAD51, but heterozygous mutant alleles suppress the defects of srs2::LEU2 cells and are semidominant in Srs2+ cells. The results of this study are interpreted to mean that wild-type Rad51 protein binds to single-stranded DNA and that the semidominant mutations do not prevent this binding. The cloning and sequencing of RAD51 indicated that the gene encodes a predicted 400-amino-acid protein with a molecular mass of 43 kDa. Sequence comparisons revealed homologies to domains of Escherichia coli RecA protein predicted to be involved in DNA binding, ATP binding, and ATP hydrolysis. The expression of RAD51, measured with a RAD51-lacZ gene fusion, was found to be UV- and gamma-ray-inducible, with dose-dependent responses.