Miracle-dz/UniFAR-FTUs huggingface dataset:
Heat Transfer in a 90° T-junction

Electrical machines are used in an ever-increasing number of applications, such as transportation systems and energy production, because of their high efficiency. The improvement of their cooling is of interest in order to increase the energy produced per unit volume. To that end, radial channels can be placed inside the stator, allowing the internal fluid to pass through, from the air gap where the mean flow is longitudinal to an external channel. To investigate both the flow between the air gap and the radial channels, and the induced convective heat transfer, an experimental set-up is used. Two fans, whose power can be adjusted, are used to create flows in the two longitudinal channels, which represent the air gap, and the external channel of the real machine. A thin heat foil is used to heat one channel face, and the temperature profiles are measured using an infrared camera. Convective heat transfer coefficients are determined along the radial centerline of each channel face by a conductive 1D model coupled with an inverse method. The inlet Reynolds number is kept constant at approximately 25000, and the mass flow rate ratio between the perpendicular channel and the inlet varies from 0.13 to 0.88. In particular, we will pay special attention to the heat transfers at channel entrances, where PIV measurements are also made. Recirculation areas, whose size are linked to the dynamic conditions, occur and have a direct influence on the local Nusselt numbers.
Nuancing the Limitations of Axonal Plasticity in World Health Organization Grade II Gliomas: White Matter Tracts Compensation Is Driven by Cortical Remodeling

Diffuse World Health Organization grade II glioma (GIIG) is a slow-growing brain cancer that migrates along the white matter (WM) tracts. Neuroplastic changes were described in reaction to GIIG progression, opening the window to extensive cerebral surgical resection in patients able to resume an active life with no functional consequences. However, atlases of cortico-subcortical neural plasticity emphasized the limited potential of axonal reorganization. Yet, the removal of WM involved by GIIG can be possible, at least to some extent, without generating permanent neurological disturbances. Here, the aim was to discuss mechanisms underlying functional compensation which make feasible resection of the subcortical component of GIIG and to propose a new model of adaptative neural reconfiguration at the level of the axonal connectivity. In this model, 2 parts of the WM tracts are considered: (1) the stem of the bundle that represents the actual limitation of plastic potential, as supported by reproducible behavioral disorders elicited by intraoperative axonal electrostimulation mapping (ESM) and (2) the terminations/origins of the bundle that may no longer be critical in case of functional reallocation of the cortex to/from which these WM fibers run—thus inducing no behavioral troubles during direct ESM. Understanding that a certain degree of axonal compensation in specific portions of the tracts is driven by cortical remodeling may enable to rethink the concept of WM plasticity and to refine the preoperative estimation of extent of resection for GIIG. Identifying eloquent fibers by ESM, especially their convergence in the depth, is essential to achieve an individualized connectome-based resection.
REDRESS: Generating Compressed Models for Edge Inference Using Tsetlin Machines

Inference at-the-edge using embedded machine learning models is associated with challenging trade-offs between resource metrics, such as energy and memory footprint, and the performance metrics, such as computation time and accuracy. In this work, we go beyond the conventional Neural Network based approaches to explore Tsetlin Machine (TM), an emerging machine learning algorithm, that uses learning automata to create propositional logic for classification. We use algorithm-hardware co-design to propose a novel methodology for training and inference of TM. The methodology, called REDRESS, comprises independent TM training and inference techniques to reduce the memory footprint of the resulting automata to target low and ultra-low power applications. The array of Tsetlin Automata (TA) holds learned information in the binary form as bits: <inline-formula><tex-math notation="LaTeX">$\lbrace 0,1\rbrace$</tex-math><alternatives><mml:math><mml:mrow><mml:mo>{</mml:mo><mml:mn>0</mml:mn><mml:mo>,</mml:mo><mml:mn>1</mml:mn><mml:mo>}</mml:mo></mml:mrow></mml:math><inline-graphic xlink:href="maheshwari-ieq1-3268415.gif"/></alternatives></inline-formula>, called excludes and includes, respectively. REDRESS proposes a lossless TA compression method, called the include-encoding, that stores only the information associated with includes to achieve over 99% compression. This is enabled by a novel computationally minimal training procedure, called the Tsetlin Automata Re-profiling, to improve the accuracy and increase the sparsity of TA to reduce the number of includes, hence, the memory footprint. Finally, REDRESS includes an inherently bit-parallel inference algorithm that operates on the optimally trained TA in the compressed domain, that does not require decompression during runtime, to obtain high speedups when compared with the state-of-the-art Binary Neural Network (BNN) models. In this work, we demonstrate that using REDRESS approach, TM outperforms BNN models on all design metrics for five benchmark datasets viz. MNIST, CIFAR2, KWS6, Fashion-MNIST and Kuzushiji-MNIST. When implemented on an STM32F746G-DISCO microcontroller, REDRESS obtained speedups and energy savings ranging 5-5700× compared with different BNN models.
On the equations of motion of point particles

The equations of motion of a point particle, possessing a charge, dipole or higher multipole moments and having an interaction with a generalized wave field of an arbitrary integral spin, are obtained explicitly. These equations are independent of the particular choice of the energy-momentum tensor of the field from among the many alternatives given by Fierz. A convenient method for the calculation of the radiation field is given. The definition of the spin of the particle is given, and it is postulated that the magnitude of this spin is constant. It is shown that this assumption effects a great simplification in the equations of a charged dipole in a vector-meson field. The equations are determined completely in terms of two arbitrary constants which are to be interpreted as the mass and the spin. Further, it is shown that only those dipoles for which the ‘electric’ and the ‘magnetic’ moments are parallel in the rest system are consistent with this assumption. The equations of motion of a charged dipole in a scalar-meson field are derived. These equations also contain only two arbitrary constants which again are to be interpreted as the mass and the spin.
Paris Agreement could prevent regional mass extinctions of coral species

Coral reef ecosystems are expected to undergo significant declines over the coming decades as oceans become warmer and more acidic. We investigate the environmental tolerances of over 650 Scleractinian coral species based on the conditions found within their present‐day ranges and in areas where they are currently absent but could potentially reach via larval dispersal. These “environmental envelopes” and connectivity constraints are then used to develop global forecasts for potential coral species richness under two emission scenarios, representing the Paris Agreement target (“SSP1‐2.6”) and high levels of emissions (“SSP5‐8.5”). Although we do not directly predict coral mortality or adaptation, the projected changes to environmental suitability suggest considerable declines in coral species richness for the majority of the world's tropical coral reefs, with a net loss in average local richness of 73% (Paris Agreement) to 91% (High Emissions) by 2080–2090 and particularly large declines across sites in the Great Barrier Reef, Coral Sea, Western Indian Ocean, and Caribbean. However, at the regional scale, we find that environmental suitability for the majority of coral species can be largely maintained under the Paris Agreement target, with 0%–30% potential net species lost in most regions (increasing to 50% for the Great Barrier Reef) as opposed to 80%–90% losses under High Emissions. Projections for subtropical areas suggest that range expansion will give rise to coral reefs with low species richness (typically 10–20 coral species per region) and will not meaningfully offset declines in the tropics. This work represents the first global projection of coral species richness under oceanic warming and acidification. Our results highlight the critical importance of mitigating climate change to avoid potentially massive extinctions of coral species.
Identifying recurrent breast cancer patients in national health registries using machine learning

Abstract Background More than 4500 women are diagnosed with breast cancer each year in Denmark, however, despite adequate treatment 10–30% of patients will experience a recurrence. The Danish Breast Cancer Group (DBCG) stores information on breast cancer recurrence but to improve data completeness automated identification of patients with recurrence is needed. Methods We included patient data from the DBCG, the National Pathology Database, and the National Patient Registry for patients with an invasive breast cancer diagnosis after 1999. In total, relevant features of 79,483 patients with a definitive surgery were extracted. A machine learning (ML) model was trained, using a simplistic encoding scheme of features, on a development sample covering 5333 patients with known recurrence and three times as many non-recurrent women. The model was validated in a validation sample consisting of 1006 patients with unknown recurrence status. Results The ML model identified patients with recurrence with AUC-ROC of 0.93 (95% CI: 0.93–0.94) in the development, and an AUC-ROC of 0.86 (95% CI: 0.83–0.88) in the validation sample. Conclusion An off-the-shelf ML model, trained using the simplistic encoding scheme, could identify recurrence patients across multiple national registries. This approach might potentially enable researchers and clinicians to better and faster identify patients with recurrence and reduce manual patient data interpretation.
Effect of melatonin on low and high dose radiotherapy induced thyroid injury

ABSTRACT We investigated the radioprotective effect of melatonin (MEL) against thyroid gland damage in rats caused by flattening filter (FF) and flattening filter free (FFF) single dose X-ray beams. We used 48 female rats divided into six groups of eight: group 1, untreated control group; group 2, MEL treated group; group 3, FF-low dose rate radiotherapy (FF-LDR) group; group 4, FF-LDR + MEL group; group 5, FFF-high dose rate radiotherapy (FFF-HDR) group; group 6, FFF-HDR + MEL group. Groups 2, 4 and 6 rats were injected intraperitoneally (i.p.) with 10 mg/kg MEL 15 min before exposure to radiation. The head and neck regions of each rat in groups 3 and 5 and groups 4 and 6 were irradiated with 16 Gy at 6 MV X-ray in FF and FFF beam modes. The histopathology of the thyroid gland and salient biochemical parameters were assessed in all rats 10 days after radiotherapy. We found increased inflammation, vacuolization, degradation, swelling and necrosis, and M30 apoptosis and M65 necrosis indicators in groups 3 and 5 compared to group 1; however, we found significant reductions in histopathological and biochemical parameters following application of MEL. MEL treatment before FF-LDR and FFF-HDR radiotherapy minimized thyroid gland injury due to irradiation.
The first recent case of Cimex hemipterus (Hemiptera: Cimicidae) with super-kdr mutations in the Republic of Korea

With the increase in international travel and trade, in conjunction with the development of insecticide resistance, infestations of Cimex lectularius (L.) and Cimex hemipterus (F.) (Hemiptera: Cimicidae) have resurged globally in the last 2 decades. Recently, it was reported that C. hemipterus was also found in temperate regions, indicating the possibility of its expansion outside tropical regions. Cimex hemipterus has not been officially recorded in Korea since its initial description in 1934. Here, we report the first recent case of C. hemipterus in Korea based on morphological and molecular identification. Partial sequencing of the voltage-sensitive sodium channel gene revealed super-kdr mutations (M918I and L1014F) that are associated with pyrethroid resistance. This case report serves as a warning to intensify the bed bug surveillance system in Korea regarding the presence of C. hemipterus and to prepare effective alternative insecticides for pyrethroids.
Role of RNA Domain Structure and Orientation in the Coxsackievirus B3 Virulence Phenotype

Human enteroviruses, which include five different species and over 100 serotypes, are responsible for diseases ranging from mild respiratory infections to serious infections of pancreas, heart, and neural tissue. All enteroviral RNA genomes have a long and highly structured 5′ untranslated region (5′ UTR) containing an internal ribosome entry site (IRES). ABSTRACT Coxsackievirus B3 (CVB3) is an enterovirus that causes diseases such as pancreatitis and myocarditis in humans. Approximately 10% of the CVB3 RNA genome consists of a highly structured 5′ untranslated region (5′ UTR) that is organized into six domains and contains a type I internal ribosome entry site (IRES). These features are common to all enteroviruses. Each RNA domain plays a vital role in translation and replication during the viral multiplication cycle. We used SHAPE-MaP chemistry to generate secondary structures of the 5′ UTR from the avirulent strain CVB3/GA and the virulent strain CVB3/28. Our comparative models show how key nucleotide substitutions cause major restructuring of domains II and III of the 5′ UTR in CVB3/GA. Despite these structural shifts, the molecule maintains several well-characterized RNA elements, which allows persistence of the unique avirulent strain. The results shed light on the 5′ UTR regions serving as virulence determinants and those required for fundamental viral mechanisms. We used the SHAPE-MaP data to produce theoretical tertiary models using 3dRNA v2.0. These models suggest a compact conformation of the 5′ UTR from the virulent strain CVB3/28 that brings critical domains into close contact. In contrast, the model of the 5′ UTR from the avirulent strain CVB3/GA suggests a more extended conformation where the same critical domains are more separated. Our results suggest that the structure and orientation of RNA domains in the 5′ UTR are responsible for low-efficiency translation, low viral titers, and absence of virulence observed during infection by CVB3/GA. IMPORTANCE Human enteroviruses, which include five different species and over 100 serotypes, are responsible for diseases ranging from mild respiratory infections to serious infections of pancreas, heart, and neural tissue. All enteroviral RNA genomes have a long and highly structured 5′ untranslated region (5′ UTR) containing an internal ribosome entry site (IRES). Major virulence determinants are located in the 5′ UTR. We present RNA structure models that directly compare the 5′ UTR derived from virulent and avirulent strains of the enterovirus coxsackievirus B3 (CVB3). The secondary-structure models show rearrangement of RNA domains known to be virulence determinants and conservation of structure in RNA elements known to be vital for translation and replication in the avirulent strain CVB3/GA. The tertiary-structure models reveal reorientation of RNA domains in CVB3/GA. Identifying the details of structure in these critical RNA domains will help direct antiviral approaches to this major human pathogen.
Association between serum uric acid levels and clinical outcomes in patients with acute kidney injury

Abstract Background The effects of serum uric acid (SUA) on clinical outcomes in patients with acute kidney injury (AKI) are unclear. The aim of this study was to investigate the association of SUA levels with clinical outcomes of AKI patients. Methods The data of AKI patients hospitalized in the Affiliated Hospital of Qingdao University were retrospectively reviewed. Multivariable logistic regression was utilized to assess the association between SUA levels and the clinical outcomes of AKI patients. Receiver operating characteristic (ROC) analysis was applied to assess the predictive ability of SUA levels for in-hospital mortality in patients with AKI. Results A total of 4,646 AKI patients were eligible for study inclusion. In multivariable analysis, after adjustment for various confounding factors in the fully adjusted model, a higher SUA level was found to be associated with increased in-hospital mortality of AKI patients with an odds ratio (OR) of 1.72 (95% CI, 1.21–2.33, p = 0.005) for the SUA level >5.1–6.9 mg/dl group and 2.75 (95% CI, 1.78–4.26, p < 0.001) for the SUA level >6.9 mg/dl group compared with the reference group (SUA ≤3.6 mg/dl). In the ROC analysis, the area under the curve (AUC) of SUA was 0.65 with a sensitivity of 51% and a specificity of 73%. Conclusions An elevated SUA level is associated with an increased risk of in-hospital mortality in patients with AKI, and it appears to be an independent prognostic marker for these patients.
Improved Event-Triggered Dynamic Output Feedback Control for Networked T–S Fuzzy Systems With Actuator Failure and Deception Attacks

This article addresses the problem of event-triggered dynamic output feedback controller design for networked Takagi-Sugeno (T–S) fuzzy systems subject to actuator failure and deception attacks. In order to save network resources effectively, two event-triggered schemes (ETSs) are introduced to test whether the measurement output and control input are transmitted under network communication. While the ETS brings advantages, it also leads to a mismatch between the premise variables of the system and the controller. To solve this problem, an asynchronous premise reconstruct method is considered, which relaxes the condition of the previous results that the premises of the plant and the controller are synchronous. Furthermore, two crucial factors, including actuator failure and deception attacks, are taken into consideration simultaneously. Then, the mean square asymptotic stability conditions of the resultant augmented system are derived by utilizing the Lyapunov stability theory. Besides, controller gains and event-triggered parameters are co-designed with the help of linear matrix inequality techniques. Finally, a cart-damper-spring system and a nonlinear mass-spring-damper mechanical system are presented to verify the theoretical analysis.
A multiplexed barcode approach to simultaneously evaluate gene delivery by adeno-associated virus capsid variants in nonhuman primates

Background and Aims: Adeno-associated virus (AAV) vectors are widely used to deliver therapeutic transgenes to distinct tissues, including the liver. Vectors based on naturally occurring AAV serotypes as well as vectors using engineered capsids have shown variations in tissue tropism and level of transduction between different mouse models. Moreover, results obtained in rodents frequently lack translatability into large animal studies. In light of the increasing interest in AAV vectors for human gene therapy, an increasing number of studies are being performed in nonhuman primates. To keep animal numbers to a minimum and thus optimize the process of AAV capsid selection, we developed a multiplex barcoding approach to simultaneously evaluate the in vivo vector performance for a set of serotypes and capsid-engineered AAV vectors across multiple organs. Approach and Results: Vector biodistribution and transgene expression were assessed by quantitative PCR, quantitative reverse transcription PCR, vector DNA amplicon Illumina sequencing and vRNAseq in male and female rhesus macaques simultaneously dosed with a mixture of barcoded naturally occurring or engineered AAV vectors encoding the same transgene. As expected, our findings show animal-to-animal variation in both the biodistribution and tissue transduction pattern, which was partly influenced by each animal’s distinctive serological status. Conclusions: This method offers a robust approach to AAV vector optimization that can be used to identify and validate AAV vectors for gene delivery to potentially any anatomical site or cell type.
Normal saline: Past, present, and future

Normal saline (NS) is the most widely used agent in the medical field. However, from its origin to its widespread application, it remains a mystery. Moreover, there is an ongoing debate on whether its existence is reasonable, harmful to the human body, or will still exist in the future. The current review traces back to the origins of NS and provides a brief overview of the current situation of infusion. The purpose may shed some light on the possibility of the existence of NS in the future by elaborating on the origin of NS and the research status of the impact of NS on the human body.
Intraoperative Direct Sonication of Implants and Soft Tissue for the Diagnosis of Periprosthetic Joint Infection

Background: Sonication is very efficacious for the microbiological diagnosis of periprosthetic joint infection (PJI), but it involves many steps and multiple workplaces and personnel and therefore carries a potential contamination risk. We present an innovative version of the sonication culture method that involves direct sonication of the retrieved implant and soft tissue, without a sonication tube, intraoperatively and incubation using a BACT/ALERT 3D blood culture system to enhance the efficacy of microbiological diagnosis of PJI. Methods: We performed a prospective study of consecutive patients requiring implant removal and classified them as having PJI or aseptic failure according to standard criteria. The removed prosthetic components and adjacent soft tissue were directly sonicated in a small metal container, without a sonication tube, during the operation. The sonication fluid was immediately incubated in blood culture bottles in the operating room and cultured in the BACT/ALERT 3D blood culture system. The synovial fluid was also cultured in the BACT/ALERT 3D system to serve as a comparison. Results: Of the 64 included patients, 36 had PJI and 28 had aseptic failure. Fluid from direct sonication and conventional synovial fluid showed sensitivities of 91.7% and 55.6% (p < 0.001) and specificities of 82.1% and 92.9%, respectively. Fourteen cases of PJI were detected by culture of fluid from direct sonication but not by culture of synovial fluid. Higher sensitivity was obtained by direct sonication of only tissue than by direct sonication of only the implant (88.9% versus 75.0%). No significant difference in detection time was found between Staphylococcus aureus and coagulase-negative Staphylococcus. Conclusions: When combined with incubation in BACT/ALERT bottles, direct intraoperative sonication of implants and soft tissues without a sonication tube was more sensitive than conventional synovial fluid culture and could reliably and rapidly detect the bacteria commonly found in PJI. Level of Evidence: Diagnostic Level II. See Instructions for Authors for a complete description of levels of evidence.