Miracle-dz/UniFAR-FTUs huggingface dataset:
The Role of Hyperbaric Oxygen in the Treatment of Diabetic Foot Ulcers

Diabetic foot ulcers are still extremely difficult to heal. Therefore, therapeutic options to improve healing rates are continuously being explored. Hyperbaric oxygen (HBO) has been used in addition to standard treatment of the diabetic foot for more than 20 years. Evidence suggests that HBO reduces amputation rates and increases the likelihood of healing in infected diabetic foot ulcers, in association with improved tissue oxygenation, resulting in better quality of life. Nonetheless, HBO represents an expensive modality, which is only available in few centers. Moreover, adverse events necessitate a closer investigation of its safety. Finally, it is not entirely clear which patients stand to benefit from HBO and how these should be selected. In conclusion, HBO appears promising, but more experience is needed before its broad implementation in the routine care of the diabetic foot.
The Readability of Path‐Preserving Clusterings of Graphs

Graph visualization systems often exploit opaque metanodes to reduce visual clutter and improve the readability of large graphs. This filtering can be done in a path‐preserving way based on attribute values associated with the nodes of the graph. Despite extensive use of these representations, as far as we know, no formal experimentation exists to evaluate if they improve the readability of graphs.
Society for Ambulatory Anesthesia Guidelines for the Management of Postoperative Nausea and Vomiting

The present guidelines were compiled by a multidisciplinary international panel of individuals with interest and expertise in postoperative nausea and vomiting (PONV) under the auspices of The Society of Ambulatory Anesthesia. The panel critically evaluated the current medical literature on PONV to provide an evidence-based reference tool for the management of adults and children who are undergoing surgery and are at increased risk for PONV. In brief, these guidelines identify risk factors for PONV in adults and children; recommend approaches for reducing baseline risks for PONV; identify the most effective antiemetic monotherapy and combination therapy regimens for PONV prophylaxis; recommend approaches for treatment of PONV when it occurs; and provide an algorithm for the management of individuals at increased risk for PONV.
Two activators of microtubule-based vesicle transport

Cytoplasmic dynein purified by nucleotide dependent microtubule affinity has significant minus end-directed vesicle motor activity that decreases with each further purification step. Highly purified dynein causes membrane vesicles to bind but not move on microtubules. We exploited these observations to develop an assay for factors that, in combination with dynein, would permit minus end-directed vesicle motility. At each step of the purification, non-dynein fractions were recombined with dynein and assayed for vesicle motility. Two activating fractions were identified by this method. One, called Activator I, copurified with 20S dynein by velocity sedimentation but could be separated from it by ion exchange chromatography. Activator I increased only the frequency of dynein-driven vesicle movements. Activator II, sedimenting at 9S, increased both the frequency and velocity of vesicle transport and also supported plus end movements. Our results suggest that dynein-based motility is controlled at multiple levels and provide a preliminary characterization of two regulatory factors.
Peer-Olaf Siebers and Paul Davidsson ( 2015 ) Engineering Agent-Based Social Simulations : An Introduction

This special section on "Engineering Agent-Based Social Simulations" aims to represent the current state of the art in using Software Engineering (SE) methods in ABSS. It includes a mixture of theoretically oriented papers that describe frameworks, notations and methods adapted from SE and practice-oriented papers that demonstrate the application of SE methods in real world ABSS projects.
Identification and Avoidance of Potential Artifacts and Misinterpretations in Nanomaterial Ecotoxicity Measurements

Novel physicochemistries of engineered nanomaterials (ENMs) offer considerable commercial potential for new products and processes, but also the possibility of unforeseen and negative consequences upon ENM release into the environment. Investigations of ENM ecotoxicity have revealed that the unique properties of ENMs and a lack of appropriate test methods can lead to results that are inaccurate or not reproducible. The occurrence of spurious results or misinterpretations of results from ENM toxicity tests that are unique to investigations of ENMs (as opposed to traditional toxicants) have been reported, but have not yet been systemically reviewed. Our objective in this manuscript is to highlight artifacts and misinterpretations that can occur at each step of ecotoxicity testing: procurement or synthesis of the ENMs and assessment of potential toxic impurities such as metals or endotoxins, ENM storage, dispersion of the ENMs in the test medium, direct interference with assay reagents and unacknowledged indirect effects such as nutrient depletion during the assay, and assessment of the ENM biodistribution in organisms. We recommend thorough characterization of initial ENMs including measurement of impurities, implementation of steps to minimize changes to the ENMs during storage, inclusion of a set of experimental controls (e.g., to assess impacts of nutrient depletion, ENM specific effects, impurities in ENM formulation, desorbed surface coatings, the dispersion process, and direct interference of ENM with toxicity assays), and use of orthogonal measurement methods when available to assess ENMs fate and distribution in organisms.
Non-invasive measurement of local pulse pressure by pulse wave-based ultrasound manometry (PWUM)

Central blood pressure (CBP) has been established as a relevant indicator of cardiovascular disease. Despite its significance, CBP remains particularly challenging to measure in standard clinical practice. The objective of this study is to introduce pulse wave-based ultrasound manometry (PWUM) as a simple-to-use, non-invasive ultrasound-based method for quantitative measurement of the central pulse pressure. Arterial wall displacements are estimated using radiofrequency ultrasound signals acquired at high frame rates and the pulse pressure waveform is estimated using both the distension waveform and the local pulse wave velocity. The method was tested on the abdominal aorta of 11 healthy subjects (age 35.7±16 y.o.). PWUM pulse pressure measurements were compared to those obtained by radial applanation tonometry using a commercial system. The average intra-subject variability of the pulse pressure amplitude was found to be equal to 4.2 mmHg, demonstrating good reproducibility of the method. Excellent correlation was found between the waveforms obtained by PWUM and those obtained by tonometry in all subjects (0.94 < r < 0.98). A significant bias of 4.7 mmHg was found between PWUM and tonometry. PWUM is a highly translational method that can be easily integrated in clinical ultrasound imaging systems. It provides an estimate of the pulse pressure waveform at the imaged location, and may offer therefore the possibility to estimate the pulse pressure at different arterial sites. Future developments include the validation of the method against invasive estimates on patients, as well as its application to other large arteries.
Gene Ontology Consortium: going forward

The Gene Ontology (GO; http://www.geneontology.org) is a community-based bioinformatics resource that supplies information about gene product function using ontologies to represent biological knowledge. Here we describe improvements and expansions to several branches of the ontology, as well as updates that have allowed us to more efficiently disseminate the GO and capture feedback from the research community. The Gene Ontology Consortium (GOC) has expanded areas of the ontology such as cilia-related terms, cell-cycle terms and multicellular organism processes. We have also implemented new tools for generating ontology terms based on a set of logical rules making use of templates, and we have made efforts to increase our use of logical definitions. The GOC has a new and improved web site summarizing new developments and documentation, serving as a portal to GO data. Users can perform GO enrichment analysis, and search the GO for terms, annotations to gene products, and associated metadata across multiple species using the all-new AmiGO 2 browser. We encourage and welcome the input of the research community in all biological areas in our continued effort to improve the Gene Ontology.
Tuning the surface microstructure of titanate coatings on titanium implants for enhancing bioactivity of implants

Biological performance of artificial implant materials is closely related to their surface characteristics, such as microtopography, and composition. Therefore, convenient fabrication of artificial implant materials with a cell-friendly surface structure and suitable composition was of great significance for current tissue engineering. In this work, titanate materials with a nanotubular structure were successfully fabricated through a simple chemical treatment. Immersion test in a simulated body fluid and in vitro cell culture were used to evaluate the biological performance of the treated samples. The results demonstrate that the titanate layer with a nanotubular structure on Ti substrates can promote the apatite-inducing ability remarkably and greatly enhance cellular responses. This highlights the potential of such titanate biomaterials with the special nanoscale structure and effective surface composition for biomedical applications such as bone implants.
Transcription yield of fully 2′-modified RNA can be increased by the addition of thermostabilizing mutations to T7 RNA polymerase mutants

On average, mutations are deleterious to proteins. Mutations conferring new function to a protein often come at the expense of protein folding or stability, reducing overall activity. Over the years, a panel of T7 RNA polymerases have been designed or evolved to accept nucleotides with modified ribose moieties. These modified RNAs have proven useful, especially in vivo, but the transcriptional yields tend to be quite low. Here we show that mutations previously shown to increase the thermal tolerance of T7 RNA polymerase can increase the activity of mutants with expanded substrate range. The resulting polymerase mutants can be used to generate 2′-O-methyl modified RNA with yields much higher than enzymes currently employed.
Bone microarchitecture in hemodialysis patients assessed by HR-pQCT.

BACKGROUND AND OBJECTIVES Dialysis patients are at high risk for low-trauma bone fracture. Bone density measurements using dual-energy x-ray absorptiometry (DXA) do not reliably differentiate between patients with and without fractures. The aim of this study was to identify differences in bone microarchitecture between patients with and without a history of fracture using high-resolution peripheral quantitative computed tomography (HR-pQCT). DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Seventy-four prevalent hemodialysis patients were recruited for measurements of areal bone mineral density (aBMD) by DXA and bone microarchitecture by HR-pQCT. Patients with a history of trauma-related fracture were excluded. Forty healthy volunteers served as controls. Blood levels of parathyroid hormone, vitamin D, and markers of bone turnover were determined. RESULTS Dialysis patients, particularly women, had markedly impaired bone microarchitecture. Patients with fractures had significantly reduced cortical and trabecular microarchitecture compared with patients without fractures. aBMD tended to be lower in patients with fractures, but differences were statistically not significant. The strongest determinant of fracture was the HR-pQCT-measured trabecular density of the tibia, which also had the highest discriminatory power to differentiate patients according to fracture status. Radial DXA had a lower discriminatory power than trabecular density. CONCLUSIONS Bone microarchitecture is severely impaired in dialysis patients and even more so in patients with a history of fracture. HR-pQCT can identify dialysis patients with a history of low-trauma fracture.
A fusion control of master steering input and automatic assisted control for teleoperated electric vehicle

The driving of unmanned vehicle has been realized step by step by the automatic vehicle in recent years. On the other hand, it is difficult to drive the unmanned vehicle full automatically in the environment in which the information is insufficient. Therefore, people have to drive the vehicle proactively in such an environment, and the teleoperated vehicle is one solution. The defect of teleoperated vehicle is its poor operability, so assist control should be added to drive the teleoperated vehicle safely. However, there is a problem that the effectiveness of assisted control depends on the sensor accuracy. In this paper, a driver assistance system that does not depend on the sensor accuracy heavily is proposed by fusing the human input and the automatic assisted control based on potential method and virtual impedance control. Steer-by-wire is introduced into the steering wheel of the vehicle so as to realize vehicle teleoperation and assisted control. The validity of proposed method is verified by simulations.
Cytoscape and its plugins

A lathe has two diametrically opposed and simultaneously operating tool slides which are powered so as to be displaceable toward and away from each other and the workpiece being machined. A timing mechanism, independent of the drive to each slide, interconnects the two slides to assure accurate equal displacement of the two slides toward and away from each other.
CD-TDS: Change detection in transactional data streams for frequent pattern mining

Online mining is a difficult task especially when such data streams evolve over time. Evolving data stream occurs when concepts drift or change completely, is becoming one of the core issues. A large portion of change detection research are carried out in the area of supervised learning, very little has been carried out for unlabeled data specifically in the area of transactional data streams. Overall when we monitor changes in transactional data we can consider two different types of changes: local and global change. Local changes are changes in distribution of the data, whereas global changes are data composition changes within the data stream. To detect changes in transactional data streams containing unlabeled data, we introduce a new technique called CD-TDS, that detects both these changes. Our change detector can identifies changes in relationships between items as data evolves with the progression of a stream. Crucially, detection of global drift enables us to better understand the dynamics in relationships that takes place over time. Experimental results using both real world and synthetic data show that the proposed approach is robust to noise and identifies structural changes with a high true positive rate while preserving a low false alarm rate.
Inhibition of bacteriophage replication by extrachromosomal genetic elements.

INTRODUCTION . 52 INHIBITION OF PHAGE REPLICATION BY LAMBDA LYSOGENS . 53 Inhibition of T-Even rI Mutants . 63 Inhibition of Ti and T5 . 6. 5 INHIBMON BY OTHER LYSOGENIZED PHAGE 65 P2and P2-Like-Induced Abortive Infections.66 P22-Induced Abortive Infections 67 ABORTIVE INFECTION MEDIATED BY THE F FACTOR 67 R-FACTOR-INDUCED INHIBMON OF PHAGE GROWTH. 60 COLICINOGENIC PLASMID-INDUCED ABORTIVE INFECTION. 60 ColIb Factor-Induced Abortive-Infection of T6 and BF23 60 Inhibition ofT7 and Related Phages. 63 Inhibition of Phage W31 by ColB2 63 OTHER INHIBITED INFECTIONS 64 CONCLUSIONS. 64 LITERATURE CITED 66
Effects of Demographic Characteristics, Health-Related Behaviors and Lifestyle Factors on the Prevalence of Hypertension for the Middle-Aged and Elderly in the Guangxi Hei Yi Zhuang and Han Populations

Background/Aims: Hei Yi (meaning black worship and black dress) Zhuang is the most conservative group among the 43 ethnic subgroups of Zhuang in China due to its unique culture and customs. The prevalence of hypertension in this population has not been well defined. Therefore, the present study was undertaken to compare the effects of the demographic characteristics, health-related behaviors and lifestyle factors on the prevalence of hypertension in the middle-aged and elderly of the Guangxi Hei Yi Zhuang and Han populations. Methods:A total of 657 people of Hei Yi Zhuang aged 40 and over were randomly selected from 7 villages in Napo County of China. Information on the demographic characteristics, health-related behaviors and lifestyle factors was collected by questionnaire. Blood pressure, height, weight, waist circumference, serum lipid and apolipoprotein levels were measured, and body mass index (BMI) was calculated as a measure of weight relative to height. The results were compared with those of 520 Han who live in the same district. Results: The prevalence of hypertension and isolated systolic hypertension in Hei Yi Zhuang was significantly higher than in Han (32.9 vs. 24.6%, p < 0.01, and 16.7 vs. 5.2%, p < 0.001, respectively). The systolic blood pressure levels and pulse pressure in Hei Yi Zhuang were also significantly higher than in Han (129 ± 20.1 vs. 125.8 ± 17.4 mm Hg, p < 0.01, and 51.5 ± 16.1 vs. 47.1 ± 12.0 mm Hg, p < 0.01, respectively). The prevalence of hypertension was positively correlated with triglycerides, male, age, and alcohol consumption in Hei Yi Zhuang, whereas it was positively correlated with total cholesterol, male, age, alcohol consumption and BMI in Han. The rates of awareness, treatment and control in Hei Yi Zhuang and Han are 7.9 vs. 19.5%, 4.2 vs. 13.3% and 1.4 vs. 9.4% (p < 0.01 for all), respectively. Conclusion: The current study reveals a significant difference in the prevalence of hypertension, blood pressure levels, and the relative factors between the Hei Yi Zhuang and Han ethnic groups, which may have been due to differences in geographical characteristics, lifestyle, sodium intake, education levels, and even genetic factors.
Soft Constraints at Interfaces

Assuming that grammar is best modeled as a set of modules each representing a constraint system, like other human cognitive faculties, these constraint systems are bound to disagree and soft constraints are needed for conflict resolution among modules. This paper outlines an approach to incorporate soft constraints among grammar modules. The paper first goes over the issue of modularity and conflicting requirements. It then summarizes a generalized theory of soft constraint satisfaction (SCSP). It then outlines a linguistic constraint system based on SCSP theory. Finally, it shows how the type antecedent constraints of HPSG can be extended in an SCSP-based framework to allow for constraint violations and gradient constraints.
Biomarkers of Dairy Fatty Acids and Risk of Cardiovascular Disease in the Multi‐Ethnic Study of Atherosclerosis

Background Evidence regarding the role of dairy fat intake in cardiovascular disease (CVD) has been mixed and inconclusive. Most earlier studies have used self‐reported measures of dietary intake and focused on relatively racially homogeneous populations. Circulating biomarkers of dairy fat in a multiethnic cohort provide objective measures of dairy fat intake and facilitate conclusions relevant to populations with different diets and susceptibility to CVD. Methods and Results In a multiethnic cohort of 2837 US adults aged 45 to 84 years at baseline (2000–2002), phospholipid fatty acids including 15:0, 14:0, and trans‐16:1n7 were measured using standardized methods, and the incidence of CVD prospectively adjudicated. Self‐reported whole‐fat dairy and butter intakes had strongest associations with 15:0, rather than 14:0 or trans‐16:1n7. In multivariate models including demographics and lifestyle and dietary habits, each SD‐unit of 15:0 was associated with 19% lower CVD risk (hazard ratio [95% CI] 0.81 [0.68 to 0.98]) and 26% lower coronary heart disease (CHD) risk (0.74 [0.60 to 0.92]). Associations were strengthened after mutual adjustment for 14:0 and trans‐16:1n‐7 and were similar after adjustment for potential mediators. Plasma phospholipid 14:0 and trans‐16:1n‐7 were not significantly associated with incident CVD or CHD. All findings were similar in white, black, Hispanic, and Chinese American participants. Conclusion Plasma phospholipid 15:0, a biomarker of dairy fat, was inversely associated with incident CVD and CHD, while no association was found with phospholipid 14:0 and trans‐16:1n‐7. These findings support the need for further investigation of CVD effects of dairy fat, dairy‐specific fatty acids, and dairy products in general.
Empirical Estimation of Leaf Chlorophyll Density in Winter Wheat Canopies Using Sentinel-2 Spectral Resolution

A comparison between the sensitivities to leaf chlorophyll density at the canopy scale of several vegetation indices (VIs) obtained at different spectral resolutions was carried out using spectral reflectance collected in winter wheat field trials with different nitrogen fertilization levels. A total of 350 spectra were collected from experimental plots at Feekes growth stages 5, 6, and 9 using a portable spectroradiometer (ASD FieldSpec HH), along with Minolta SPAD measurements of leaf optical thickness as a proxy for leaf chlorophyll density. Indices based on visible and near-infrared (NIR) bands were obtained from average reflectance in spectral ranges corresponding to SPOT HRG and Sentinel-2 (S2) bands. Indices requiring a red-edge band were obtained from reflectance at the originally proposed VI wavelengths using the 1.6-nm nominal spectral resolution bandwidth of the spectroradiometer and from average reflectance in the S2 red-edge bands with the closest spectral position to VI originally proposed wavelengths. Among VIs obtained from Sentinel-2 bands MERIS terrestrial chlorophyll index, red-edge position and triangular chlorophyll index/optimized soil adjusted VI ratio (TCI/OSAVI) indices, obtainable at 20-m spatial resolution from future S2 red-edge bands, and chlorophyll VI (CVI), obtainable at 10 m from visible and NIR bands, were the best estimators of winter wheat leaf chlorophyll density. The sensitivity of the best-performing indices obtained from S2 bands to winter wheat with other conditions was addressed by the analysis of a large synthetic data set obtained using the PROSPECT-SAILH model in the direct mode. Analysis of the synthetic data set using Sentinel-2 spectral resolution indicates that the two leaf area index normalized (TCI/OSAVI and CVI) indices are better leaf chlorophyll estimators.
Fabrication of radial ZnO nanowire clusters and radial ZnO/PVDF composites with enhanced dielectric properties

Using an improved microemulsion process novel ZnO nanostructures can be prepared on a large scale. These radial ZnO nanowires grow on hexagonal prism tips and form nanowire clusters. A detailed study of variations in dielectric properties dependent on frequency and temperature shows that composites of radial ZnO and PVDF have significantly higher dielectric constants and exhibit better thermal stability than bulk ZnO/PVDF composites as well as showing a low percolation threshold. Already a low content of radial ZnO increases the dielectric constant of the polymer matrix significantly to a value above 100.