Miracle-dz/UniFAR-FTUs huggingface dataset:
The miR-503 cluster is coordinately under-expressed in endometrial endometrioid adenocarcinoma and targets many oncogenes, cell cycle genes, DNA repair genes and chemotherapy response genes

Background The miR-503 miRNA cluster, located at Xq23.1, is composed of six miRNAs; miR-424, miR-503, miR-542, miR-450a-1, miR-450a-2 and miR-450b. Numerous studies have focused on the relationship of one or two members of the cluster and various human cancers. Here, we suggest that the entire cluster as a single coordinately expressed polycistron transcribed from a single promoter in endometrial endometrioid adenocarcinoma (EEA). Subjects and methods A tissue panel composed of twenty histologically confirmed endometrial endometrioid adenocarcinomas (EEA) and four benign endometrium was assembled under informed consent. Expression of each member of the miR-503 cluster was determined by quantitative PCR and differences in expression between EEA and benign tissues were assessed via the standard ΔΔCt method. In addition, the role of promoter methylation status in miRNA expression was examined in Ishikawa H cells following exposure to the cytidine analog Decitabine. Results Expression of each member of the miR-503 cluster is significantly downregulated in EEA in our tumor sample. Both in our tumor sample and in The Cancer Genome Atlas (TCGA) there is evidence of highly correlated expression further supporting the idea that the miR-503 cluster is a polycistron. Looking at each member of the miR-503 cluster we were able to identify 55 unique experimentally validated target genes which include a substantial number of genes involved in carcinogenesis, DNA damage response, cell cycle regulation and chemotherapeutic response. We also found preliminary evidence that regulation of the miR-503 cluster is governed by methylation of the promoter in EEA. Conclusion The totality of the data presented here strongly suggest that the miR-503 cluster as a whole merits further investigation as an important potential therapeutic target in EEA.
This paper is included in the

Randomized cache architectures have proven to signiﬁcantly increase the complexity of contention-based cache side-channel attacks and therefore present an important building block for side-channel secure microarchitectures. By random-izing the address-to-cache-index mapping, attackers can no longer trivially construct minimal eviction sets which are fundamental for contention-based cache attacks. At the same time, randomized caches maintain the ﬂexibility of traditional caches, making them broadly applicable across various CPU types. This is a major advantage over cache partitioning approaches. A large variety of randomized cache architectures has been proposed. However, the actual randomization function received little attention and is often neglected in these proposals. Since the randomization operates directly on the critical path of the cache lookup, the function needs to have extremely low latency. At the same time, attackers must not be able to bypass the randomization which would nullify the security beneﬁt of the randomized mapping. In this paper, we propose SCARF (Secure CAche Randomization Function), the ﬁrst dedicated cache randomization cipher which achieves low latency and is cryptographically secure in the cache attacker model. The design methodology for this dedicated cache cipher enters new territory in the ﬁeld of block ciphers with a small 10-bit block length and heavy key-dependency in few rounds.
Features, Behavioral Change Techniques, and Quality of the Most Popular Mobile Apps to Measure Physical Activity: Systematic Search in App Stores (Preprint)

BACKGROUND It is estimated that 23% of adults and 55% of older adults do not meet the recommended levels of physical activity. Thus, improving the levels of physical activity is of paramount importance, but it requires the use of low-cost resources that facilitate universal access without depleting the health system. The high number of apps available constitutes an opportunity, but it also makes it quite difficult for the layperson to select the most appropriate app. Furthermore, the information available in the app stores is often insufficient, lacks quality, and is not evidence based, and the systematic reviews fail to assess app quality using standardized and validated instruments. OBJECTIVE The objective of this study was to systematically assess the features, content, and quality of the most popular apps that can be used to measure and, potentially, promote physical activity. METHODS Systematic searches were conducted on Apple App Store, Google Play, and Windows Phone Store between December 2017 and January 2018. Apps were included if their primary objective was to assess the aspects of physical activity, if they had a user rating of at least 4, if their number of ratings was ≥100, and if they were free. Apps meeting these criteria were independently assessed by two reviewers regarding their general and technical information, aspects of physical activity, presence of behavioral change techniques, and quality. Data were analyzed using means and SDs or frequencies and percentages. RESULTS Of 51 apps included, none specified the age of the target group and only one mentioned the involvement of health professionals. Most apps offered the possibility to work in background (n=50) and allowed data sharing (n=40). Regarding physical activity, most apps measured steps and distance (n=11) or steps, distance, and time (n=17). Only 18 apps, all of which measured number of steps, followed the guidelines on recommendations for physical activity. On average, 5.5 (SD 1.8) behavioral change techniques were identified per app; the most frequently used techniques were “provide feedback on performance” (n=50) and “prompt self-monitoring of behavior” (n=50). The overall quality score was 3.88 (SD 0.34). CONCLUSIONS Although the overall quality of the apps was moderate, the quality of their content, particularly the use of international guidelines on physical activity, should be improved. Additionally, a more in-depth assessment of apps should be performed before releasing them for public use, particularly regarding their reliability and validity.
Intimate Partner Violence Perpetration by Court-Ordered Men

This study continues previous work documenting the structure of violence perpetrated by males against their female intimate partners. It assesses the construct validity of a measurement model depicting associations among eight subtypes of perpetration: moderate physical violence, severe physical violence, forced or coerced sexual violence, sexual violence where consent was not possible, emotional/verbal psychological abuse, dominance/isolation psychological abuse, interactional contacts/surveillance related stalking, and stalking involving mediated contacts. Data were obtained from a sample of 340 men arrested for physical assault of a female spouse or partner, and court ordered into batterer intervention programs. Men were surveyed before starting the intervention. Confirmatory factor analyses (CFA) supported the validity of model as evidenced by good model to data fit and satisfaction of requirements for fit statistics. In addition, the eight factor solution was characterized by a slightly better model to data fit than a four factor higher order solution described in the author’s previous work. Latent variable correlations across the broader categories of intimate partner violence (IPV) revealed that the violence subtypes were mostly moderately positively correlated and ranged from . 381 (emotional/verbal psychological abuse with interactional contacts/surveillance related stalking) to . 795 (dominance/isolation psychological with abuse with forced sex). Future studies should determine whether there are distinct risk factors and health outcomes associated with each of the eight IPV perpetration subtypes and identify possible patterns of co-occurrence.
Cognitive Rehabilitation in Multiple Sclerosis in the Period from 2013 and 2021: A Narrative Review

Background: In recent years, several blinded randomized controlled trials (RCT) have been conducted on cognitive rehabilitation (CR) in adults with multiple sclerosis (MS). Objective: To review all blinded RCTs on CR in MS published since 2013. Methods: The National Library of Medicine database (Medline) and PSYCINFO were searched using the keywords MS and CR or cognitive training or NP rehabilitation or memory rehabilitation or attention rehabilitation. Results: After the exclusion of some papers not specifically focused on CR, a final list of 26 studies was established. The papers belong to three main categories: individual specific rehabilitation (8studies), group rehabilitation (4 studies), and computerized training (CT) (14 studies), while one study combined group rehabilitation and CT. Among the individual rehabilitation studies, 5 were devoted to memory, and most of the 19 other selected studies were about several cognitive domains. Most of the studies mainly concerned RRMS patients, except for 2 studies that were carried out exclusively in progressive forms. Despite the methodological limitations of some studies and the great heterogeneity of the protocols, the results are generally in favor of the efficacy of CR in neuropsychological tests. Conclusion: Recent blinded RCTs about CR in MS show promising results.
Allosteric mechanism of the V. vulnificus adenine riboswitch resolved by four-dimensional chemical mapping

The structural interconversions that mediate the gene regulatory functions of RNA molecules may be different from classic models of allostery, but the relevant structural correlations have remained elusive in even intensively studied systems. Here, we present a four-dimensional expansion of chemical mapping called lock-mutate-map-rescue (LM2R), which integrates multiple layers of mutation with nucleotide-resolution chemical mapping. This technique resolves the core mechanism of the adenine-responsive V. vulnificus add riboswitch, a paradigmatic system for which both Monod-Wyman-Changeux (MWC) conformational selection models and non-MWC alternatives have been proposed. To discriminate amongst these models, we locked each functionally important helix through designed mutations and assessed formation or depletion of other helices via compensatory rescue evaluated by chemical mapping. These LM2R measurements give strong support to the pre-existing correlations predicted by MWC models, disfavor alternative models, and suggest additional structural heterogeneities that may be general across ligand-free riboswitches.
Water requirements and irrigation.

Vegetable crops are normally grown intensively and need high managerial and other inputs. They are comparatively high-risk crops, with a proportionally higher cost and higher return than many others. It is usually false economy to skimp on inputs which can detrimentally affect yields and/or product quality, both of which play such a large role in determining good financial returns from the enterprise.
Geomagnetic Data Interpretation Using 2D Modeling of Subsurface Rock Layer Structures in the Palu Valley Province, Central Sulawesi

Interpretationofthesubsurfacerocklayerstructuremodelhasbeencar-ried out using geomagnetic data in the Palu Valley. Geomagnetic data is obtained through ﬁeld measurements using the Proton Precision Magnetometer. Modeling is done using total magnetic ﬁeld intensity data. The research objective is to determine the geological structure and subsurface rock layers. The modeling results show that at the study site, there are four rock layers and several faults mapped in the western, central, and eastern parts of the study location. Based on the susceptibility value, the rock structure at the study site consists of granite and sedimentary rocks, but the types of sedimentary rocks are different. The layer on the surface consists of alluvium according to what is exposed in the ﬁeld. The second layer is thought to be sandstone which extends in harmony with the rock above it from west to east. The third layer is in the form of sandy clay which extends from the central part to the east and is not aligned with the layer above it while the lowest layer consists of granite rocks that are faulted in the western and eastern parts of the study area.
Symptomatic BK Virus Infection Is Associated With Kidney Function Decline and Poor Overall Survival in Allogeneic Hematopoietic Stem Cell Recipients

Nephropathy due to BK virus (BKV) infection is an evolving challenge in patients undergoing hematopoietic stem cell transplantation (HSCT). We hypothesized that BKV infection was a marker of kidney function decline and a poor prognostic factor in HSCT recipients who experience this complication. In this retrospective study, we analyzed all patients who underwent their first allogeneic HSCT at our institution between 2004 and 2012. We evaluated the incidence of persistent kidney function decline, which was defined as a confirmed reduction in estimated glomerular filtration rate of at least 25% from baseline using the Chronic Kidney Disease Epidemiology equation. Cox proportional hazard regression was used to model the cause‐specific hazard of kidney function decline, and the Fine–Gray method was used to account for the competing risks of death. Among 2477 recipients of a first allogeneic HSCT, BK viruria was detected in 25% (n = 629) and kidney function decline in 944 (38.1%). On multivariate analysis, after adjusting for age, sex, acute graft‐versus‐host disease (GVHD), chronic GVHD, preparative conditioning regimen, and graft source, BK viruria remained a significant risk factor for kidney function decline (p < 0.001). In addition, patients with BKV infection and kidney function decline experienced worse overall survival. After allogeneic HSCT, BKV infection was strongly and independently associated with subsequent kidney function decline and worse patient survival after HSCT.
Genetic Approach for Improved Prediction of Adaptive Learning Activities in Intelligent Tutoring System

—The intelligent tutoring system registers the reference data of the learners in a database. This data is stored for later use in the instructional module. Designing a student model is not an easy task. It is first necessary to identify the knowledge acquired by the learner, then identify the learner's level of understanding of the functionality and finally identify the pedagogical strategies used by the learner to solve a problem. These elements must be taken into account in the development of the learner model. Learner characteristics must be considered in several forms. To build an effective learner model, the system must take into consideration both static (Learner preferences) and dynamic (Compartmental action) student characteristics. The objective of the article is to work out the learner model of the intelligent tutoring system by suggesting a new learning path. This proposal is based on the constructivist approach and the activist style (based on experimentation). According to the KOLB model, the authors propose a list of pedagogical activities depending on the learners' profile. Based on the learners' actions, the system reduces the list of activities based on two criteria: the learner's preference and the presence of one or more activities based on the activist style using genetic algorithm as an evolutionary algorithm. The results obtained led us to improve the learning process through a new conception of the ITS learner model.
Shaped Power Pattern Synthesis With Minimization of Dynamic Range Ratio

The problem of synthesizing array patterns while reducing dynamic range ratio (DRR) of complex excitations is of great importance in practical applications since it enables active arrays to be more attractive by appropriately controlling the mutual coupling between the neighboring elements, as well as reducing the cost and complexity of the feeding network design. Unlike the commonly adopted DRR control technique, this paper focuses on minimizing the DRR of the excitations while synthesizing the anticipated array pattern, which results in a new nonconvex and nonlinear optimization problem because of its fractional objective function and nonconvex constraints. By introducing auxiliary variables, we derive an equivalent optimization problem that transforms the fractional objective function into a linear one, decompose the original optimization problem into several subproblems in each iteration, and simplify them as either single-variable quadratic unconstrained optimization or least-squares problems that are solved efficiently in each iteration. Numerical results with different radiation requirements are shown to demonstrate the effectiveness of the proposed scheme.
Transcatheter hepatic arterial infusion chemotherapy vs sorafenib in the treatment of patients with hepatocellular carcinoma of Barcelona clinic liver cancer stage c: a meta-analysis of asian population

Objective: To compare the clinical efficacy and safety of transcatheter hepatic arterial infusion chemotherapy (HAIC) with those of sorafenib in the treatment of patients with hepatocellular Methods: Potentially relevant studies comparing the clinical efficacy and safety of HAIC with those of sorafenib were searched using Medline, PubMed, Embase, Cochrane Library, and Chinese databases (Wanfang Data and China National Knowledge Infrastructure). Overall survival rate (OSR), tumor response rate, disease control rate (DCR), and serious adverse events (SAEs) were compared and analyzed. Pooled ORs with 95% CIs were calculated using either the fixed-effects model or the random-effects model. All statistical analyses were conducted using Review Manager (version 5.3) from the Cochrane Collaboration. Results: meta-analysis. The results of this study HAIC objective 0.11; OR 0.53, 95% CI SAE : [0.14–1.92], P SAE = 0.33). Conclusion: This study showed that HAIC was associated with better efficacy than sorafenib in terms of OSR and tumor response. Therefore, HAIC can be considered as an alternative treatment option for patients with HCCs of BCLC stage C.
Edinburgh Explorer 11-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis

11 (cid:1) -Hydroxysteroid dehydrogenase type-1 (11 (cid:1) -HSD1) converts inert cortisone into active cortisol, amplifying intracellular glucocorticoid action. 11 (cid:1) HSD1 deﬁciency improves cardiovascular risk factors in obesity but exacerbates acute inﬂammation. To determine the effects of 11 (cid:1) -HSD1 deﬁciency on atherosclerosis and its inﬂammation, atherosclerosis-prone apolipoprotein E-knockout (ApoE-KO) mice were treated with a selective 11 (cid:1) -HSD1 inhibitor or crossed with 11 (cid:1) -HSD1-KO mice to generate
Patients awaiting surgical repair for large abdominal aortic aneurysms are able to exercise at 1 moderate to hard intensities with a low risk of adverse events 2

1School of Social Sciences, Business and Law, Teesside University, United Kingdom, 2Health and Social Care Institute, Teesside University, United Kingdom, 3Department of Sport, Exercise and Rehabilitation, Northumbria University, United Kingdom, 4Department of Academic Anaesthesia, South Tees Hospitals NHS Foundation Trust, United Kingdom, 5Department of Anaesthesia, Northern General Hospital, Sheffield Teaching Hospitals Foundation Trust, United Kingdom, 6Department of Anaesthesia, York Hospital, United Kingdom, 7Sheffield Vascular Institute, Northern General Hospital, United Kingdom
Measurement of service quality of “Trotro” as public transportation in Ghana: A case study of the city of Kumasi

An efficient urban transportation system is essential for providing adequate mobility to satisfy various socio-economic needs. In developed countries, the majority of public transportation is usually provided by the state. Contrary, in developing countries, public transportation services . mostly provided by privately-owned operators resulting in greater diversity in service provision. These private transport operators often provide services on a large part of the transport system under highly competitive but poorly regulated conditions. The trend of relying on the private sector to provide public transport services has resulted in a large number of individual operators focuses more on maximize profit instead of safety and quality of service. Their operations are characterized by no time schedules, delays, longer turn-around time as well as unilateral decision. The number and frequency of service on any given route can change daily thereby undermining the quality of service provided to the public. This paper assesses customers’ satisfaction of the services provided by the minibuses (“trotro”) in the City of Kumasi, Ghana regarding the expected and perceived quality of service. The service quality (SERVQUAL) model was used to analyze results of the study. It was found from statistical analyses that there are gaps between passengers and operators perception in terms of quality of service provided by the ‘trotro’ as public transport. Based on this finding, it is recommended that the trotro industry should therefore implement programmes aimed at improving customer satisfaction. The improvement must target better security services at the terminals through lighting and provision of personnel for 24 hours and information through the use of public address system and maps. Additionally, cleanliness must be improved upon both at the stations and inside the buses and the grounds should be paved and sanitation taken up by efficient cleaning service operators.
effects of paliperidone extended release on hostility among Thai patients with schizophrenia

and aggressive behavior subscale ( P  0.001) (n = 148). Conclusion: Switching from previously unsuccessful antipsychotic treatments to paliperidone ER may be a useful option to reduce hostility and disturbing behavior in patients with schizophrenia. This study in Thai patients is in line with findings in other countries and cultures concerning the management of
POLIPLOÏDIA, FILOGÈNIA I BIOGEOGRAFIA EN CENTAUREA L. SECCIÓ ACROCENTRON (Cass.) DC.

El grup Acrocentron s'ha anat classificant i estructurant de diferents maneres al llarg dels anys, pero segons l'ultima definicio del grup estaria format per Centaurea sect. Acrocentron, a mes de dues seccions molt petites, Centaurea sect. Chamaecyanus i Centaurea sect. Stephanochilus. Aquest grup es caracteritza cariologicament per ser un grup amb un elevat numero d'especies poliploides.En aquest treball hem intentat establir l'origen de dues series poliploides dins d' Acrocentron , examinar els limits del grup i aclarir els centres de radiacio i dispersio d' Acrocentron a partir de l'origen geografic del grup.Hem comprovat que el fenomen de la poliploidia esta condicionat per l'intens flux genetic existent entre les especies iberiques i les nord-africanes.Els estudis filogenetics i biogeografics assenyalen que el grup Acrocentron queda reduit a dues seccions (Centaurea sect. Chamaecyanus adoptaria el rang de subseccio dins de la sect. Acrocentron), de tota manera no es possible fer una bona classificacio subseccional degut als alts nivells d'hibridacio i d'introgressio.Hem establert el lloc d'origen del grup Acrocentron i s'ha reconstruit la seva expansio des de l'Est de la mediterrania, en concret a la zona d'Anatolia, cap a la resta de centres d'especiacio. L'expansio mes antiga, que finalitza al plioce, va portar a la sect. Acrocentron cap al sud d'Italia, Sicilia, Africa del Nord i la Peninsula Iberica. L'altra radiacio, molt posterior (durant les glaciacions del neogen), va estendre Acrocentron des del nord dels Balcans cap al nord de la peninsula Iberica i fins a Asia Central, en una distribucio continua eurasiatica.