Miracle-dz/UniFAR-FTUs huggingface dataset:
Lycorine Carbamate Derivatives for Reversing P-glycoprotein-Mediated Multidrug Resistance in Human Colon Adenocarcinoma Cells

Multidrug resistance (MDR) is a major challenge in cancer chemotherapy. Aiming at generating a small library of anticancer compounds for overcoming MDR, lycorine (1), a major Amaryllidaceae alkaloid isolated from Pancratium maritimum, was derivatized. Thirty-one new compounds (2–32) were obtained by chemical transformation of the hydroxyl groups of lycorine into mono- and di-carbamates. Compounds 1–32 were evaluated as MDR reversers, through the rhodamine-123 accumulation assay by flow cytometry and chemosensitivity assays, in resistant human colon adenocarcinoma cancer cells (Colo 320), overexpressing P-glycoprotein (P-gp, ABCB1). Significant inhibition of P-gp efflux activity was observed for the di-carbamate derivatives, mainly those containing aromatic substituents, at non-cytotoxic concentrations. Compound 5, bearing a benzyl substituent, and compounds 9 and 25, with phenethyl moieties, were among the most active, exhibiting strong inhibition at 2 µM, being more active than verapamil at 10-fold higher concentration. In drug combination assays, most compounds were able to synergize doxorubicin. Moreover, some derivatives showed a selective antiproliferative effect toward resistant cells, having a collateral sensitivity effect. In the ATPase assay, selected compounds (2, 5, 9, 19, 25, and 26) were shown to behave as inhibitors.
Measurement of initial conditions of a flying golf ball

We considered that the flying distance and curve of a golf ball are determined by the initial conditions of a golf ball (five parameters, that is, initial velocity, the elevation of delivery, the angle of left-right deviation, backspin and sidespin) immediately after being hit. The instrument for measuring these parameters simultaneously has been developed, and is characterized by carrying out the measurement of the spin with laser Doppler velocimeters. In this instrument, attention was paid to the fact that the surface velocity of a flying ball is determined by summing the flying velocity and the spin, and to measure the surface velocity of a ball immediately after being hit was aimed at. By using this instrument, the relation of these five parameters with carry was measured. <<ETX>>
Aperture-Coupled Reflectarrays with Enhanced Bandwidth Features

An extensive analysis is performed on the aperture-coupled reflectarray configuration to highlight and quantify the bandwidth enhancement due to the use of reduced inter-element spacings. Bandwidth extension is directly evaluated on the phase curves relative to the reflection coefficient against frequency for different lengths of the tuning line. The operating frequency range computed with the proposed approach is numerically validated on the gain patterns of synthesized reflectarrays and a strong broadband behavior is demonstrated for reflectarrays of moderate aperture dimensions and reduced unit cell size.
First-Year Implementation of the EXercise for Cancer to Enhance Living Well (EXCEL) Study: Building Networks to Support Rural and Remote Community Access to Exercise Oncology Resources

Barriers to exercise-oncology programs remain for those living with and beyond cancer in rural and remote communities, including geographic isolation and access to programs. The EXercise for Cancer to Enhance Living Well (EXCEL) study was designed to support exercise-oncology implementation in rural and remote communities across Canada. The purpose of this analysis was to evaluate the first-year reach, adoption, and implementation of the EXCEL study. Reach outcomes included participant characteristics, study enrolment, and referral type (self vs. healthcare-provider [HCP] referral). Adoption outcomes included the number of clinical contacts, trained qualified exercise professionals (QEPs), and QEPs delivering EXCEL exercise classes. Implementation outcomes included retention, adherence, assessment completion rates, and adverse-event reporting. A total of 290 individuals living with cancer enrolled in EXCEL in year one, with an 81.4% retention to the study intervention. Most participants self-referred to EXCEL (75.8%). EXCEL’s HCP network consisted of 163 clinical contacts, and the QEP network included 45 trained QEPs, 22 of whom delivered EXCEL classes. Adherence to the exercise intervention was 78.2%, and only one adverse event (mild) was reported. Fitness assessment and patient-reported outcome completion rates were above 85% pre- and post-intervention. EXCEL has developed HCP and QEP networks supporting exercise referral and online delivery, and the intervention is meeting feasibility markers. These implementation findings will inform the continued gathering of feedback across stakeholders to ensure that best evidence informs best practices.
Application of simulation software for NDT for civil engineering

Simulation is a powerful means in the design of inspection methods. It minimizes the number of iterations when building probe prototypes, optimizing inspection techniques and defining the test procedures. It is known to be valuable in supporting performance and reliability demonstrations requiring a lot of data (e.g., POD studies and qualification campaigns), where simulation can reduce the number of necessary mock-ups and experimental trials. Largely used in different industrial sectors, there is still great potential for NDT modelling remaining in the civil engineering field. The aging infrastructures, and the increasing needs for reliable evaluations of structural integrity require deeper investigations and developments, in which modelling can be of great help. The CIVA platform is a well-established multi technique simulation and analysis software in NDT. Developed by CEA LIST, but also resulting from the contribution of numerous industrial and academic partners within Europe, it implements concepts of numerical efficiency, imaging, and reliability demonstration. The range of NDT methods in CIVA includes UT, GWT, ET, RT, CT, Thermography and is extended by Structural Health Monitoring applications based on guided ultrasonic waves. In addition to physical models dedicated to metallic inspections largely used in the industry, CIVA offers the capacity to simulate ultrasonic inspections in other media such as concrete. It has recently included the definition of probes polarized to generate shear waves at 0°, thus capturing the current state-of-the art for concrete inspections. This contributes significantly to the potential for studies and inspection planning in the field of concrete inspections, which helps tremendously in ensuring reliable inspections. While such studies would require enormous computational effort for most other simulation techniques, the semi-analytical approach of CIVA makes it highly efficient and application-oriented. This paper illustrates models available in the ultrasonic module of CIVA and best practices for application cases in civil engineering.
Formation Control of Networked Mobile Robots With Unknown Reference Orientation

In this article, the distributed leader-following formation control problem of networked mobile robots is investigated. The desired formation is specified by a reference trajectory generated by the leader and the followers' desired relative positions with respect to the leader. On the one hand, for any security-aware multirobot systems, the values of the leader's position and orientation are generally not allowed to be transmitted via the inter-robot communication in the case of the information leakage of formation caused by the possible eavesdropping. On the other hand, relative orientations, different from relative positions, are typically difficult for mobile robots to measure directly, which makes the reference orientation unknown to all followers. In order to track the reference trajectory and form a desired formation in the absence of the reference orientation, followers are divided into two groups according to whether they are able to directly measure the relative positions with respect to the leader. The topology of the sensing/communication network among multirobot systems is described by a directed graph containing a directed spanning tree. Then, two observer-based control laws are proposed for two groups of followers, respectively, in both of which the unknown tracking errors are properly estimated. It is rigorously proven that the resulting closed-loop multirobot system is globally uniformly asymptotically stable. Finally, the effectiveness of our approach is illustrated by an experiment conducted on networked TurtleBot3 Burger mobile robots.
An Extended CO Source around Comet 29P/Schwassmann-Wachmann 1

Abstract Comet 29P/Schwassmann–Wachmann 1 has been studied during seven days in August 1998 with the SEST submillimeter telescope at ESO, La Silla, Chile. The CO ( J =2−1) emission at 230 GHz was mapped by directing the telescope beam at the nucleus and six off-nucleus positions. The CO line profiles exhibit the blue- and redshifted components previously observed by various observers. The strength of the observed lines does not decrease with projected distance to the nucleus as expected if CO molecules were coming from the nucleus only. Instead, the line area is nearly constant throughout the map. This can be explained if CO molecules are being released from both the sunlit side of the nucleus and CO-bearing particles distributed in a shell-like cloud. The extended source must consist of icy grains globally moving toward the Sun at ∼50 m s −1 released ∼30 days before the observations were made. The nuclear and extended sources produce (7±1)×10 27 and 2.4×10 28 molecules s −1 , respectively. Our 1996 observations of the comet (Festou, M., M. Gunnarsson, A. Winnberg, H. Rickman, and G. Tancredi 2001. Icarus 150 , 140–150) were reexamined using this new two-source model. In this case, the nuclear and extended CO sources produced 10±1×10 27 and 2.9×10 28 CO molecules s −1 , respectively. It is not necessary to postulate night side outgassing, but a large quantity of solid grains has to be expelled into the coma.
English First Additional Language: Teachers’ written feedback practices in multi-grade classrooms in rural South African primary schools

Multi-grade teaching is a widely accepted phenomenon in both developing and developed countries. In this article I report on a phenomenological inquiry into written feedback practices of teachers in multi-grade classrooms and how they described and interpreted their feedback practices pertaining to learners’ writing activities in English First Additional Language. Written feedback is widely believed to be central to learners’ learning and achievement. Feedback is assumed to change learners’ thinking or behaviour towards their work and is regarded as a tool to focus their attention on improving their learning. Despite the benefits of written feedback, however, there is a widespread belief that many learners are disengaged from the feedback they receive. The population in this study comprised 4 English First Additional Language teachers from 4 multi-grade primary schools. Content analysis was used to analyse the data collected from the participants through semi-structured interviews. The findings indicate that participants differed in their understanding of what was involved in feedback, and that there was a shared view that feedback was a product and not viewed as a process that could be used towards developing learners’ learning. It was also shown that feedback practices used by the teachers of multi-grade classes included providing correct answers and providing delayed feedback to learners. This study adds to the ongoing debates on multi-grade teaching and attempts to shed some light on the nature and the type of feedback that could motivate and enhance learners’ learning in multi-grade classrooms.
Not robots; Cyborgs — Furthering anti-ableist research in human-computer interaction

This theoretical essay builds on existing literature to draw out the consequences of dehumanizing and disseminating autism discourses within the field of human-computer interaction (HCI). Focusing mainly on narratives in HCI that frame autistic people as or like machines, we explore how dominant constructions of autism in HCI work to normalize the field’s complicity in violent autism intervention paradigms, despite HCI researchers’ well-meaning intentions. We work towards developing crip-cyborgs as an alternative framework for understanding autistic people (as opposed to computers or robots) and suggest crip technoscience as a framework for research based on this alternative understanding. In doing so, we hope to enroll misguided but well-intentioned researchers in dismantling anti-autistic ableism, both in and beyond HCI.
Estimation of Nonparametric Autoregressive Time Series Models Under Dynamical Constraints

Abstract. A method is introduced to estimate nonparametric autoregressive models under the additional constraint that its regression function has a stable cycle. It is based on a penalty approach that chooses a series expansion approximation taking into account both goodness‐of‐fit and fulfillment of the constraint. Consistency of the proposed estimator is obtained under general hypothesis. Feasibility and effective performance of the introduced method are studied through simulated examples and electro‐encephalographic data collected from a subject suffering from epilepsy.
Subgrid-Scale Models for Large-Eddy Simulations of Shock-Boundary-Layer Interactions

Direct numerical simulation and large-eddy simulation of a flat-plate supersonic turbulent boundary layer interacting with an oblique incident shock wave are conducted for a priori and a posteriori assessments of subgrid-scale models. The incident shock is strong enough to generate a marginal separation in the boundary layer near the interaction region providing the subgrid-scale models with a nontrivial challenge. The governing equations for direct numerical simulation and large-eddy simulation are solved by a new seventh-order monotonicity-preserving scheme for inviscid fluxes and a sixth-order compact finite-difference scheme for the viscous terms. The effect of subgrid-scale stress term on the resolved velocity field is shown to be significant and shock-dependent. The subgrid-scale models tested include the mixed-time-scale model, the dynamic Smagorinsky model, the dynamic mixed model and a new dynamic model termed the compressible serial-decomposition model. A priori analysis indicate that the new dy.
A Single-Actuator Four-Finger Adaptive Gripper for Robotic Assembly

Efficiently grasping and releasing objects using robotic grippers is an essential step in robotic assembly. This article presents a low-cost four-finger adaptive gripper capable of performing stable and reliable grasping operations on irregular-shaped flat objects. Unlike other grasping systems in the fixture-to-fixture robotic assembly, the assembly process using the proposed gripper does not rely on any vision systems or six-axis force/torque sensors. Specifically, assuming that the relative position $\bm {\Lambda }$ between the two fixtures is known, such assembly tasks can be accomplished simply by performing a predefined motion of a robot arm only related to $\bm {\Lambda }$. This is mainly because the developed gripper not only adapts to the shape and size of the grasped object, but also keeps its position and posture relative to the gripper unchanged throughout the grasping process. A novel underactuated grasping mechanism consisting of an X-shaped differential mechanism and two seesaw ones is proposed to perform adaptive and stable fingertip grasps with more contact points. The kinematics and statics of the gripper-object system are derived for the analysis and design of the gripper. The proposed gripper is fabricated, and a grasping system is built using a commercial robot arm (UR5) to verify its capability for adaptive grasps and assembly of difficult-to-handle flat objects. Experimental results show that it is effective to grasp objects with uncertain shape/size and position, control the grasping force, accomplish the fixture-to-fixture assembly, etc.
Structure and Evolution of the 22 February 1993 TOGA COARE Squall Line: Aircraft Observations of Precipitation, Circulation, and Surface Energy Fluxes

Abstract This study documents the precipitation and kinematic structure of a mature, eastward propagating, oceanic squall line system observed by instrumented aircraft during the Tropical Ocean Global Atmosphere Coupled Ocean–Atmosphere Response Experiment (TOGA COARE). Doppler radar and low-level in situ observations are used to show the evolution of the convection from an initially linear NNW–SSE-oriented convective line to a highly bow-shaped structure with an embedded low- to midlevel counterclockwise rotating vortex on its northern flank. In addition to previously documented features of squall lines such as highly upshear-tilted convection on its leading edge, a channel of strong front-to-rear flow that ascended with height over a “rear-inflow” that descended toward the convective line, and a pronounced low-level cold pool apparently fed from convective and mesoscale downdrafts from the convective line; rearward, the observations of this system showed distinct multiple maxima in updraft strength with.
Pulsed thulium doped fiber laser at 1.94 μm based on a seed diode

A fiber laser operating at 1. 94μm in pulsed regime has been developed in a MOPA configuration. The seed consists of a custom-developed board hosting a laser diode, whose current is modulated to achieve the desired pulse shape, duration and repetition rate. The pulses are amplified through a thulium-doped fiber amplifier pumped at 793 nm. The design of the amplifier stage has been performed by dynamic simulation of a rate-equations model and compared to the experimental measurements. Simulations and experimental measurements have exhibited comparable results, devising the realization of an effective pulsed laser system whose parameters can be easily tuned through the seed.
Irreversibility Marangoni Tri-Hybrid Nanoflow Analysis for Thermal Enhancement Applications

Increasing heat transfer is an important part of industrial, mechanical, electrical, thermal, and biological sciences. The aim of this study is to increase the thermal competency of a conventional fluid by using a ternary hybrid nanofluid. A magnetic field and thermal radiation are used to further improve the thermal conductivity of the base fluid. Irreversibility is analyzed under the influence of the embedded parameters. The basic equations for the ternary hybrid nanofluids are transformed from Partial Differential Equations (PDEs) to Ordinary Differential Equations (ODEs) using the similarity concept. The Marangoni convection idea is used in the mathematical model for the temperature difference between the two media: the surface and fluid. The achieved results are provided and discussed. The results show that ternary hybrid nanofluids are more suitable as heat-transmitted conductors than conventional fluids.
Highly Efficient Miniaturized Magnetorheological Valves Using Electropermanent Magnets

Fluidic systems enable actuation in various applications, such as automotive, medical, and industrial robotics. Miniaturized valves constitute a fundamental controlling element of modern fluidic systems, intriguing the interest of many researchers. This letter presents the design, implementation, and experimental validation of a miniaturized magnetorheological valve. The valve is highly efficient due to its capability of sustaining high loads with low energy consumption. This work includes the estimation strategy for the sustained load. Magnetorheological fluid is used both as an actuation fluid and as control medium. The inner iron core of the traditional magnetorheological valve is replaced with an AlNiCo-5 rod. The latter provides the possibility of magnetic energy storage, without continuous power supply. This changes the actuation mechanism from an electromagnet to an electropermanent magnet. The valve's capability to sustain pressure up to 1010 kPa, for a volume of 353 mm3, is demonstrated experimentally. The fluid flow rate when the valve is open is 459 mm3/s for a pressure difference of 993 kPa. The corresponding power consumption is negligible in steady-state condition, while consuming 15.3 mJ when activated and 6 mJ when deactivated. The experimental results also validate the possible tunability of the pressure sustaining capability of the valve.
Simultaneous Optimal Distribution of Lateral and Longitudinal Tire Forces for the Model Following Control

This paper presents a proposed optimum tire force distribution method in order to optimize tire usage and find out how the tires should share longitudinal and lateral forces to achieve a target vehicle response under the assumption that all four wheels can be independently steered, driven, and braked. The inputs to the optimization process are the driver's commands (steering wheel angle, accelerator pedal pressure, and foot brake pressure), while the outputs are lateral and longitudinal forces on all four wheels. Lateral and longitudinal tire forces cannot be chosen arbitrarily, they have to satisfy certain specified equality constraints. The equality constraints are related to the required total longitudinal force, total lateral force, and total yaw moment. The total lateral force and total moment required are introduced using the model responses of side-slip angle and yaw rate while the total longitudinal force is computed according to driver's command (traction or braking). A computer simulation of a closed-loop driver-vehicle system subjected to evasive lane change with braking is used to prove the significant effects of the proposed optimal tire force distribution method on improving the limit handling performance. The robustness of the vehicle motion with the proposed control against the coefficient of friction variation as well as the effect of steering wheel angle amplitude is discussed.
Set Reconciliation Using Ternary and Invertible Bloom Filters

Set reconciliation between different hosts to hold the same dataset is an important prerequisite in numerous distributed applications. Sending the entire dataset to achieve set reconciliation is inefficient if the majority of the data owned by each host is the same. Each host is required to send exclusive elements uniquely included in its set to the other to minimize communication complexity. This paper proposes an efficient algorithm for a host to identify its exclusive elements using the recursive comparison of ternary Bloom filters, each representing the signature of a subset of elements and used for filtering out subsets with identical elements. Hence, subsets with exclusive elements are identified, and elements included in the identified subsets are programmed to an invertible Bloom filter (IBF) to be sent to the other host. Thus, the number of elements programmed in the IBF is significantly reduced. Simulation results show that the proposed algorithm provides excellent performance compared with existing set reconciliation algorithms under the constraint of the same amount of data communication.
Magnetic Structure Work at the Nuclear Center of Grenoble

Three structures are briefly reported: FeRh is antiferromagnetic at low temperatures and ferromagnetic above 60°C. Fe has in both region a high moment of about 3μB ; Rh has a definite moment in the ferromagnetic region of about 0. 6μB . Cr3Se4, a nonstoichiometric compound with ordered holes, has a magnetic structure closely related to that of MnBr2. UCoO4 isomorphous of UMgO4 (space group Imma) is antiferromagnetic with Co-O-O-Co interactions and a Neel temperature of 12°K.