Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of continuous loop diuretic versus bolus injection regimens in patients with heart failure: a comprehensive meta-analysis of the literature

INTRODUCTION Heart failure (HF) is a challenging clinical syndrome and the leading cause of morbidity and mortality worldwide1. In decompensated HF patients, diuretic administration is a crucial and first-line therapeutic option for reducing fluid overload by diuresis1. Optimizing the loop diuretic dose is essential to produce a high proportion of loop diuretic transport in the proximal renal tubule, enabling it to optimally function on a Na+-K+-2Cl cotransporter on the luminal surface of the thick ascending limb of the loop of Henle2. Theoretically, continuous infusion of a loop diuretic may be preferable to intermittent bolus injection treatment in terms of length of hospital stay, weight loss, and urine output3. Possible underlying reasons may include that continuous infusion of a loop diuretic may ensure better urine output and less neurohormonal stimulation due to the constant delivery rate of the loop diuretics to the tubule, resulting in less alteration in intravascular volume and fewer occurrences of adverse side effects3. Despite the fact that most randomized controlled trials (RCTs) supported a continuous infusion in regard to diuretic efficiency, there is no convincing evidence in the present literature to indicate that continuous infusion of a loop diuretic is preferable to bolus injection treatment or vice versa1,4. As a result, we intended to perform a meta-analysis of RCTs that evaluated these two treatment options in HF patients.
Disease Burden in Patients with von Willebrand Disease Potentially Eligible for Prophylaxis: Post Hoc Analysis of a European Cross-Sectional Study

Recent international guidelines conditionally recommend von Willebrand factor (VWF) prophylaxis for von Willebrand disease (VWD) patients with a history of severe/frequent bleeds. This post hoc analysis of the Cost of VWD Across Europe, a Socioeconomic Study (CVESS; conducted in 2018), assessed patient characteristics and disease burden in patients aged >1 year with congenital VWD not receiving but potentially eligible for prophylaxis based on severe/frequent bleeds, and those receiving prophylaxis in the previous 12 months. Data were collected using medical records and a patient questionnaire. Patients considered potentially prophylaxis-eligible (n = 102) experienced more bleeds than patients receiving prophylaxis (n = 229) and were more likely to be admitted to the hospital due to bleeding events in the prior 12 months. Quality of life and work productivity were similar between the two groups. Logistic regression analysis showed that the prophylaxis-eligible group was more likely to have poor joint function and moderate chronic pain than the prophylaxis group. This retrospective study suggests that 1/7 patients not receiving VWF prophylaxis had a higher disease burden than patients receiving prophylaxis and would potentially benefit from prophylaxis.
Robust tracking and regulation control for mobile robots

Presents the design of a differentiable, robust tracking controller for a mobile robot system. The controller provides robustness with regard to parametric uncertainty and additive bounded disturbances in the dynamic model. Through the use of a dynamic oscillator and a Lyapunov-based stability analysis, we demonstrate that the position/orientation tracking errors exponentially converge to a neighborhood about zero that can be made arbitrarily small, i.e. the controller ensures that the tracking error is globally uniformly ultimately bounded (GUUB). In addition, we illustrate how the robust tracking controller can be reconfigured as a variable structure controller that ensures global exponential regulation to an arbitrary desired setpoint.
Solution of finite element problems using hybrid parallelization with MPI and OpenMP

The Finite Element Method (FEM) is used to solve problems like solid deformation and heat diffusion in domains with complex geometries. This kind of geometries requires discretization with millions of elements; this is equivalent to solve systems of equations with sparse matrices and tens or hundreds of millions of variables. The aim is to use computer clusters to solve these systems. The solution method used is Schur substructuration. Using it is possible to divide a large system of equations into many small ones to solve them more efficiently. This method allows parallelization. MPI (Message Passing Interface) is used to distribute the systems of equations to solve each one in a computer of a cluster. Each system of equations is solved using a solver implemented to use OpenMP as a local parallelization method.
Configuration perceptual learning and its relationship with element perceptual learning

Visual perceptual learning has been studied extensively and reported to enhance the perception of almost all types of training stimuli, from low- to high-level visual stimuli. Notably, high-level stimuli are often composed of multiple low-level features. Therefore, it is natural to ask whether training of high-level stimuli affects the perception of low-level stimuli and vice versa. In the present study, we trained subjects with either a high-level configuration stimulus or a low-level element stimulus. The high-level configuration stimulus consisted of two Gabors in the left and right visual fields, respectively, and the low-level element stimulus was the Gabor in the right visual field of the configuration stimulus. We measured the perceptual learning effects using the configuration stimulus and the element stimuli in both left and right visual fields. We found that the configuration perceptual learning equally improved the perception of the configuration stimulus and both element stimuli. In contrast, the element perceptual learning was confined to the trained element stimulus. These findings demonstrate an asymmetric relationship between perceptual learning of the configuration and the element stimuli and suggest a hybrid mechanism of the configuration perceptual learning. Our findings also offer a promising paradigm to promote the efficiency of perceptual learning—that is, gaining more learning effect with less training time.
An efficient non-rejective implementation of the πps sampling designs

Poisson sampling is a method for unequal probabilities sampling with random sample size. There exist several implementations of the Poisson sampling design, with fixed sample size, which almost all are rejective methods, that is, the sample is not always accepted. Thus, the existing methods can be time-consuming or even infeasible in some situations. In this paper, a fast and non-rejective method, which is efficient even for large populations, is proposed and studied. The method is a new design for selecting a sample of fixed size with unequal inclusion probabilities. For the population of large size, the proposed design is very close to the strict πps sampling which is similar to the conditional Poisson (CP) sampling design, but the implementation of the design is much more efficient than the CP sampling. And the inclusion probabilities can be calculated recursively.
The Spatial Features and Temporal Changes in the Gut Microbiota of a Healthy Chinese Population

China accounts for approximately 1/5th of the world’s total population. Differences in environment, ethnicity, and living habits could impart unique features to the structure of the gut microbiota of Chinese individuals. ABSTRACT In this study, we aimed to understand the characteristics of the gut microbial composition in a healthy Chinese population and to evaluate if they differed across different regions. In addition, we aimed to understand the changes in the gut microbial composition over time. We collected 239 fecal samples from healthy Chinese adults living in four regions and performed a 1-year time cohort study in a small population in Beijing. The Chinese gut microbiota share 34 core bacterial genera and 39 core bacterial species, which exist in all collected samples. Several disease-related microorganisms (DRMs), virulence factors, and antibiotic resistance genes were found in one or more healthy Chinese samples. Differences in gut microbiota were observed in samples from different regions, locations, individuals, and time points. Compared to other factors, time was associated with a lower degree of change in the gut microbiota. Our findings revealed spatial and temporal changes in the gut microbiota of healthy Chinese individuals. Compared to fecal microbiomes of 152 samples in the publicly released the Human Microbiome Project (HMP) project from the United States, samples in this study have higher variability in the fecal microbiome, with higher richness, Shannon diversity indices, and Pielou evenness indexes, at both the genus and species levels. The microbiota data obtained in this study will provide a detailed basis for further understanding the composition of the gut microbiota in the healthy Chinese population. IMPORTANCE China accounts for approximately 1/5th of the world’s total population. Differences in environment, ethnicity, and living habits could impart unique features to the structure of the gut microbiota of Chinese individuals. In 2016, we started to investigate healthy Chinese people and their gut microbiomes. Phase I results for 16S rRNA amplicons have been released. However, owing to the limitations of 16S rRNA amplicon sequencing, the gut microbiome of a healthy Chinese population could not be examined thoroughly at the species level, and the detailed changes in the gut microbiota over time need to be investigated. To address these knowledge gaps, we started a phase II study and investigated the basis for variations in the gut microbiome composition in a healthy Chinese population at the species level using shotgun metagenomics technology. In the phase II study, we also conducted a time scale analysis of fecal samples from healthy Chinese subjects, as a pioneered study, which quantitatively clarified the changes in the gut microbiota at both the spatial and temporal levels and elucidated the distribution pattern of DRMs in healthy Chinese individuals.
Heterogeneity and Evolutionary Tunability of Escherichia coli Resistance against Extreme Acid Stress

Acidic environments constitute one of the most important stresses for enteric bacteria and can be encountered in both natural (e.g., host gastrointestinal tract) and manmade (e.g., food processing) environments. The enteric species Escherichia coli harbors many pathovars and is well known for its ability to cope with acid stress. ABSTRACT Since acidic environments often serve as an important line of defense against bacterial pathogens, it is important to fully understand how the latter manage to mount and evolve acid resistance mechanisms. Escherichia coli, a species harboring many pathovars, is typically equipped with the acid fitness island (AFI), a genomic region encoding the GadE master regulator together with several GadE-controlled functions to counter acid stress. This study reveals that gadE and consequently AFI functions are heterogeneously expressed even in the absence of any prior acid stress, thereby preemptively creating acid-resistant subpopulations within a clonal E. coli population. Directed evolution efforts selecting for modulated gadE expression confirm that a gain-of-function mutation in the EvgS sensor kinase can constitutively upregulate gadE expression and concomitant acid resistance. However, we reveal that such upregulation of EvgS also causes cross-resistance to heat stress because of SafA-mediated cross-activation of the PhoPQ regulon. Surprisingly, loss of function of the serC gene (encoding phosphoserine/phosphohydroxythreonine aminotransferase) can also significantly upregulate gadE expression, acid resistance, and heat cross-resistance, although via a currently cryptic mechanism. As such, our data reveal a noisy expression of gadE in E. coli that is functional for the survival of sudden acid stress and that can readily be genetically tuned. IMPORTANCE Acidic environments constitute one of the most important stresses for enteric bacteria and can be encountered in both natural (e.g., host gastrointestinal tract) and manmade (e.g., food processing) environments. The enteric species Escherichia coli harbors many pathovars and is well known for its ability to cope with acid stress. In this study, we uncover that E. coli’s acid fitness island (AFI), a genomic region that encodes important functions to deal with acid stress, is by default expressed in a heterogeneous manner. In fact, using microfluidics-based single-cell approaches, we further demonstrate that this heterogeneity preemptively creates a clonal subpopulation that is much better equipped to survive a sudden acid shock. In addition, we reveal that environments with recurring acid stress can readily select for mutants displaying a higher fraction of AFI-expressing cells. These new insights are important to properly understand and anticipate the survival characteristics of E. coli.
Anteromedialization Tibial Tubercle Osteotomy Improves Patellar Contact Forces: A Cadaveric Model of Patellofemoral Dysplasia

Background: Patellofemoral (PF) dysplasia is common in patients with recurrent patellar instability. Tibial tubercle osteotomy (TTO) is performed with goals of correcting patellar maltracking and redistributing contact forces across the PF joint. The biomechanical effects of TTO in the setting of PF dysplasia have not been quantified. Purpose/Hypothesis: To quantify patellar contact mechanics and kinematics after TTO in the setting of PF dysplasia. We hypothesized that a simulated anteromedialization (AMZ) TTO would improve PF contact mechanics as compared with a pure medialization TTO. Study Design: Controlled laboratory study. Methods: PF dysplasia with Dejour type D classification was simulated in 7 cadaveric knees by replacing the native patellar and trochlear surfaces with synthetic polymeric patellar and trochlear implants. On each specimen, a flat TTO was fixed in 3 distinct positions simulating a pathologic lateralized tubercle (pathologic condition), a medialized tubercle (Elmslie Trillat), and an AMZ tubercle. The sum of forces acting on the medial and lateral patellar facet and patellar kinematics was computed for each knee for each condition from 0° to 70° of flexion at 10° increments. Results: Relative to the pathologic condition, AMZ TTO decreased contact forces across the lateral facet (20°-50° and 70° of flexion). Relative to the pathologic condition, Elmslie Trillat TTO had no effect on contact forces on either compartment. Relative to the Elmslie Trillat TTO, the AMZ TTO had significantly decreased contact forces across the medial facet (at 40°, 60°, and 70° of flexion). No significant differences in joint kinematics occurred across any groups. Conclusion: Of all groups studied, AMZ TTO resulted in significantly decreased patellar contact forces in simulated dysplastic PF joints. AMZ may be considered in certain patients with PF dysplasia to avoid medial compartment PF chondral overload. Clinical Relevance: PF dysplasia is common in patients with recurrent patellar instability who warrant surgical intervention to prevent subsequent recurrence. Numerous interventions to treat this condition, including various TTOs, have been proposed without a clear consensus. This cadaveric biomechanical study demonstrates that AMZ TTO resulted in more favorable PF contact mechanics than Elmslie Trillat TTO in a model representing PF dysplasia. AMZ TTO may be considered for patients in the setting of recurrent instability with PF dysplasia to avoid cartilage overload on the medial compartment of the PF joint.
SARS-CoV-2 Serology and Self-Reported Infection Among Adults — National Health and Nutrition Examination Survey, United States, August 2021–May 2022

CDC COVID-19 surveillance systems monitor SARS-CoV-2 antibody prevalence to collect information about asymptomatic, undiagnosed, and unreported disease using national convenience samples of blood donor data from commercial laboratories (1,2). However, nonrandom sampling of data from these systems could affect prevalence estimates (1-3). The National Health and Nutrition Examination Survey (NHANES) collects SARS-CoV-2 serology data among a sample of the general U.S. civilian population (4). In addition, NHANES collects self-reported COVID-19 vaccination and disease history, and its statistical sampling design is not based on health care access or blood donation. Therefore, NHANES data can be used to better quantify asymptomatic SARS-CoV-2 infection prevalence and seropositivity attained through infection without vaccination. Preliminary NHANES 2021-2022 results indicated that 41.6% of adults aged ≥18 years had serology indicative of past infection and that 43.7% of these adults, including 57.1% of non-Hispanic Black or African American (Black) adults, reported never having had COVID-19, possibly representing asymptomatic infection. In addition, 25.5% of adults whose serology indicated past infection reported never having received COVID-19 vaccination. Prevalences of seropositivity in the absence of vaccination were higher among younger adults and Black adults, reflecting the lower observed vaccination rates among these groups (5). These findings raise health equity concerns given the disparities observed in SARS-CoV-2 infection and COVID-19 vaccination. Results from NHANES 2021-2022 can guide ongoing efforts to achieve vaccine equity in COVID-19 primary vaccination series and booster dose coverage.
Involvement of brain‐derived neurotrophic factor methylation in the prefrontal cortex and hippocampus induced by chronic unpredictable mild stress in male mice

Early life stress alters brain‐derived neurotrophic factor (BDNF) promoter IV methylation and BDNF expression, which is closely related to the pathophysiological process of depression. However, the role of abnormal methylation of BDNF induced by stress during adolescence due to depression has not yet been clarified. In this study, adolescent mice were exposed to chronic unpredictable mild stress (CUMS). Depression‐like behaviors, BDNF promoter IV methylation, expression of DNA methyltransferases (DNMTs), demethylation machinery enzymes, BDNF protein levels, and neuronal development in the prefrontal cortex (PFC) and hippocampus (HIP) were assessed in adolescent and adult mice. The DNMT inhibitor, 5‐Aza‐2‐deoxycytidine (5‐AzaD), was used as an intervention. Stress in adolescence induces behavioral dysfunction, elevated methylation levels of BDNF promoter IV, changes in the expression of DNMT, and demethylation machinery enzymes in adolescent and adult mice. Additionally, the stress in adolescence induced lower levels of BDNF and abnormal hippocampal doublecortin (DCX) expression in adolescent and adult mice. However, DNMT inhibitor treatment in adolescent‐stressed mice relieved the abnormal behaviors, normalized the methylation level of BDNF promoter IV, BDNF protein expression, expression of DNMTs, and demethylation machinery enzymes, and improved the neuronal development of adult mice. These results suggest that stress in adolescence induces short‐ and long‐term hypermethylation of BDNF promoter IV, which is regulated by DNMTs, and leads to the development of depression.
Yield of Surveillance Imaging After Mastectomy With or Without Reconstruction for Patients With Prior Breast Cancer

Key Points Question Is surveillance imaging necessary for patients with prior breast cancer who have undergone mastectomy? Findings In this systematic review and meta-analysis of 16 relevant studies, the pooled overall cancer detection rates were lower than the Breast Imaging Reporting and Data System benchmarks for all 3 imaging modalities (mammography, ultrasonography, and magnetic resonance imaging) both for patients with reconstruction after mastectomy and for patients without reconstruction. In all clinical scenarios and imaging modalities, lower rates of clinically occult (nonpalpable) cancer compared with cancer detection rates were observed. Meaning This systematic review and meta-analysis found that the lower detection rates of clinically occult—compared with overall—cancer across all 3 imaging modalities suggest not using imaging surveillance after mastectomy, with or without reconstruction.
Loss of 4E-BPs Prevents the Hindlimb Immobilization-Induced Decrease in Protein Synthesis in Skeletal Muscle.

The present study was designed to test the hypothesis that upregulating protein synthesis attenuates the loss of muscle mass in a model of disuse atrophy. The studies compared the effect of unilateral hindlimb immobilization in wild-type (WT) mice and double-knockout (DKO) mice lacking the translational regulators 4E-BP1 and 4E-BP2. Immobilization-induced downregulation of protein synthesis occurred in both groups of mice, but protein synthesis was higher in gastrocnemius muscle from the immobilized hindlimb of fasted DKO compared to WT mice. Surprisingly, although protein synthesis was partially elevated in DKO compared to WT mice, atrophy occurred to the same extent in both groups of animals. This may be partially due to impaired leucine-induced stimulation of protein synthesis in DKO compared to WT mice due to down-regulated eukaryotic initiation factor eIF4E expression in muscle of DKO compared to WT mice. Expression of the E3 ubiquitin ligases MAFbx and MuRF-1 mRNAs and total protein ubiquitylation were upregulated in the immobilized compared with the non-immobilized hindlimb of both WT and DKO mice, with little difference in the magnitude of the upregulation between genotypes. Analysis of newly synthesized proteins revealed a downregulation of several glycolytic enzymes in the gastrocnemius of DKO mice compared to WT mice, as well as in the immobilized compared to the non-immobilized hindlimb. Overall, the results suggest that the elevated rate of protein synthesis during hindlimb immobilization in fasted DKO mice is insufficient to prevent disuse-induced muscle atrophy, probably due to induction of compensatory mechanisms including downregulation of eIF4E expression.
Smokers’ Curiosity Facilitates Recall of Tobacco-Related Health Information

ABSTRACT Curiosity promotes learning. Two open questions concern the extent to which tobacco smokers exhibit curiosity about smoking-related health information and whether this curiosity can facilitate recall of this information. Participants (n = 324 smokers; n = 280 nonsmokers) performed a Trivia Guessing Task wherein participants guessed the answers to general trivia and smoking-related trivia questions and provided ratings of their curiosity prior to viewing the answers to the questions. A subset of participants (n = 121 smokers; n = 97 nonsmokers) completed a surprise Trivia Memory Task one-week later and answered the previously-viewed questions. Results indicate that smokers are no less curious about smoking-related trivia than they are about general trivia and that curiosity about the answer to smoking-related trivia is associated with more accurate recall of smoking-related trivia answers one week later. Findings suggest that engendering states of curiosity for smoking-related information may facilitate retention of that information in smokers.