Miracle-dz/UniFAR-FTUs huggingface dataset:
Don't reinvent the wheel: the search for an identity for public administration

For many years, public administration has suffered from an identity crisis. This article argues that public administration's identity actually exists in the form of abandoned and often neglected fragments of well-established knowledge. We advocate reassembling these fragments and arranging them using a logic that will crystallize an identity for public administration. Our approach is based on viewing public administration as a social science of results, not a profession relying on a generic viewpoint. We maintain that there is a trialectic system of relationships among three pillars of public administration: the political, the legal and the managerial. The interrelationships between these pillars generate configurations, temporary arrangements geared toward certain issues. At any given time, one pillar may be emphasized over the other two. Such variations should not be viewed as a crisis of identity. Rather, this article suggests a research agenda for examining the identity of the field through longitudinal historical studies in which configurations may be identified in order to determine the conditions and circumstances that led to the variations in emphasis among the pillars. The more knowledge that is accumulated, the better we will be able to develop a reasonable approach for public administration and free it from oft-repeated cries of identity crisis. Points for practitioners Practitioners should be aware of the logic presented in this article. A logic that views the identity of public administration not in generic terms, but rather as a field of inquiry that is influential and consequential. It should be regarded as a social science of results that politicians use to solve citizens' problems. Hence, in democracies, the three pillars, the legal, the managerial and the political, interact constantly, constituting a range of public administration configurations. Configurative cyclicality should be regarded as public administration's normal, natural state of being. Normality means that a temporary configuration of the three basic pillars of the field does not testify to a crisis of identity, but constitutes an interim variation of interrelationships under special circumstances and conditions.
Cognitive Context and Arguments from Ontologies for Learning

The deployment of learning resources on the web by different experts has resulted in the accessibility of multiple viewpoints about the same topics. In this work we assume that learning resources are underpinned by ontologies. Different formalizations of domains may result from different contexts, different use of terminology, incomplete knowledge or conflicting knowledge. We define the notion of cognitive learning context which describes the cognitive context of an agent who refers to multiple and possibly inconsistent ontologies to determine the truth of a proposition. In particular we describe the cognitive states of ambiguity and inconsistency resulting from incomplete and conflicting ontologies respectively. Conflicts between ontologies can be identified through the derivation of conflicting arguments about a particular point of view. Arguments can be used to detect inconsistencies between ontologies. They can also be used in a dialogue between a human learner and a software tutor in order to enable the learner to justify her views and detect inconsistencies between her beliefs and the tutor's own. Two types of arguments are discussed, namely: arguments inferred directly from taxonomic relations between concepts, and arguments about the necessary and jointly sufficient features that define concepts.
Latency of inhibition from inside and outside the classical receptive field in macaque V1 neurons

The response of a neuron to an optimal stimulus in its classical receptive field (CRF) can be modulated by two well-known effects: surround suppression and cross-orientation inhibition. Some researchers have proposed that a common mechanism underlies these suppressive effects (Heeger, 1992) while others have suggested separate mechanisms (Sengpiel et al, 1998). We used a novel stimulus to probe the temporal dynamics of both phenomena and found that on average surround suppression occurs substantially later than the suppression caused by cross-orientation masking.
Benefits, challenges and strategies of implementing blended learning in tertiary institutes

This literature review examines first and foremost the benefits and challenges faced in implementing blended learning (BL) in tertiary institutes. It also reviews the strategies deployed by institutes in implementing blended learning. The reported key benefits were the increased passing rates of learners, decreased drop-out rates from blended learning classes and the mutual beneficiaries between the learners and the institutes. Two challenges reported that were pedagogically related were the increased complexity in the instructions and the lack of institutional support. Strategies used for implementation were varied, ranging from use of change management process to using framework or guidelines, pointing to a need for further research to successful implementation strategies and framework.
Digalactosyldiacylglycerol Is Required for Stabilization of the Oxygen-Evolving Complex in Photosystem II1[C][OA]

The galactolipid digalactosyldiacylglycerol (DGDG) is present in the thylakoid membranes of oxygenic photosynthetic organisms such as higher plants and cyanobacteria. Recent x-ray crystallographic analysis of protein-cofactor supercomplexes in thylakoid membranes revealed that DGDG molecules are present in the photosystem II (PSII) complex (four molecules per monomer), suggesting that DGDG molecules play important roles in folding and assembly of subunits in the PSII complex. However, the specific role of DGDG in PSII has not been fully clarified. In this study, we identified the dgdA gene (slr1508, a ycf82 homolog) of Synechocystis sp. PCC6803 that presumably encodes a DGDG synthase involved in the biosynthesis of DGDG by comparison of genomic sequence data. Disruption of the dgdA gene resulted in a mutant defective in DGDG synthesis. Despite the lack of DGDG, the mutant cells grew as rapidly as the wild-type cells, indicating that DGDG is not essential for growth in Synechocystis. However, we found that oxygen-evolving activity of PSII was significantly decreased in the mutant. Analyses of the PSII complex purified from the mutant cells indicated that the extrinsic proteins PsbU, PsbV, and PsbO, which stabilize the oxygen-evolving complex, were substantially dissociated from the PSII complex. In addition, we found that heat susceptibility but not dark-induced inactivation of oxygen-evolving activity was notably increased in the mutant cells in comparison to the wild-type cells, suggesting that the PsbU subunit is dissociated from the PSII complex even in vivo. These results demonstrate that DGDG plays important roles in PSII through the binding of extrinsic proteins required for stabilization of the oxygen-evolving complex.
An efficient authentication scheme based on the self-updating hash chain for campus network

A novel authentication scheme with self-updating hash chain is proposed for campus network, which realizes efficient identities authentication using the cryptographic features of hash chain. The self-updating hash chain solves the length limitation of traditional hash chain. Analysis are given to illustrate the proposed protocol is secure and efficient. Practical implementation show the given scheme is available and feasible. At last, the achievement of authentication server is stated.
Aristotle, autonomy and the explanation of behaviour

This paper examines Aristotle’s notion of autonomy and its implication for the mechanicism/autonomy debate. We introduce the basic principles of Aristotle’s scientific framework, including his theory of four causes for the explanation of nature. We draw parallels between these notions of autonomy and causation and autopoietic theory, dynamical systems and robotics, suggesting that they may be compatible with Aristotle’s framework. We argue that understanding the problem of design of autonomous robots may benefit from the consideration of integration of Aristotle’s causes, while robotics, in turn, may contribute to the debate providing a common ground for epistemological and ontological notions of autonomy.
800-168 Approximate Matching : Definition and Terminology

iii Authority This publication has been developed by NIST to further its statutory responsibilities under the Federal Information Security Management Act (FISMA), Public Law (P.L.) 107-347. NIST is responsible for developing information security standards and guidelines, including minimum requirements for Federal information systems, but such standards and guidelines shall not apply to national security systems without the express approval of appropriate Federal officials exercising policy authority over such systems. This guideline is consistent with the requirements Nothing in this publication should be taken to contradict the standards and guidelines made mandatory and binding on Federal agencies by the Secretary of Commerce under statutory authority. Nor should these guidelines be interpreted as altering or superseding the existing authorities of the Secretary of Commerce, Director of the OMB, or any other Federal official. This publication may be used by nongovernmental organizations on a voluntary basis and is not subject to copyright in the United States. Attribution would, however, be appreciated by NIST. Certain commercial entities, equipment, or materials may be identified in this document in order to describe an experimental procedure or concept adequately. Such identification is not intended to imply recommendation or endorsement by NIST, nor is it intended to imply that the entities, materials, or equipment are necessarily the best available for the purpose. There may be references in this publication to other publications currently under development by NIST in accordance with its assigned statutory responsibilities. The information in this publication, including concepts and methodologies, may be used by Federal agencies even before the completion of such companion publications. Thus, until each publication is completed, current requirements, guidelines, and procedures, where they exist, remain operative. For planning and transition purposes, Federal agencies may wish to closely follow the development of these new publications by NIST. Organizations are encouraged to review all draft publications during public comment periods and provide feedback to NIST. All NIST Computer Security Division publications, other than the ones noted above, are available at The Information Technology Laboratory (ITL) at the National Institute of Standards and Technology (NIST) promotes the U.S. economy and public welfare by providing technical leadership for the Nation's measurement and standards infrastructure. ITL develops tests, test methods, reference data, proof of concept implementations, and technical analyses to advance the development and productive use of information technology. ITL's responsibilities include the development of management, administrative, technical, and physical standards and guidelines for the cost-effective …
RGS2-mediated intracellular Ca2+ level plays a key role in the intracellular replication of Brucella abortus within phagocytes.

BACKGROUND Brucella abortus can proliferate within professional and nonprofessional phagocytic host cells and thereby successfully bypass the bacteriocidal effects of phagocytes. However, the intracellular survival mechanism and factors of virulence are not fully understood. METHODS We have investigated the role of the regulator of G protein signaling 2 (RGS2), an intracellular calcium ([Ca(2+)](i)) regulator of the host cell, in the intracellular survival of B. abortus within phagocytes. RESULTS B. abortus infection markedly induced RGS2 messenger RNA expression in early phase and increased the [Ca(2+)](i) level up to 24 hours postinfection within macrophages from wild-type mice. The [Ca(2+)](i) level, however, was not influenced by B. abortus infection within macrophages from RGS2-deficient mice. Furthermore, B. abortus survival was reduced within RGS2-deficient macrophages, and hence bacterial proliferation was inhibited in RGS2-deficient mice. Moreover, treatment with the Ca(2+) chelator ethylenediaminetetraacetic acid (EDTA) or 1,2-bis-(2-amino-phenoxy)ethane-N,N,N',N'-tetraacetic acid acetoxymethyl ester (BAPTA-AM) and the L-type Ca(2+) channel-blocking agent nifedipine or genistein also showed a reduced intracellular replication of B. abortus within macrophages. CONCLUSION These results indicate that B. abortus infection induces host RGS2 expression and that up-regulation of [Ca(2+)](i) levels is an essential factor for the intracellular survival of B. abortus within phagocytes.
Implementation of a Meningitis Care Bundle in the Emergency Room Reduces Mortality Associated With Acute Bacterial Meningitis

Background: Prompt administration of antibiotics, adjunctive steroid therapy, and optimization of antibiotic delivery to cerebrospinal fluid (CSF) are factors associated with improved outcome of patients hospitalized for acute bacterial meningitis (ABM). However, the impact of a bundle of these procedures has not been reported. Objective: To assess mortality and neurological sequelae at hospital discharge in a cohort of patients with ABM managed according to a predefined bundle. Methods: Prospective study of all the patients hospitalized for ABM in two provinces of Northern Italy, over two consecutive periods (2005-2009, 2010-2013). The bundle included: i) supportive care if needed; ii) immediate administration of dexamethasone and 3rd generation cephalosporin; and iii) addition of levofloxacin if turbid CSF. Patients managed according to the bundle were compared with a historical group of patients cared for ABM before the bundle was implemented. Results: Overall, 85 patients with ABM were managed according to the bundle and were compared with 92 historical controls. In-hospital mortality rates for bundle and control group were 4.7% and 14.1% (p=0.04). Among survivors, 13.5% and 18.9% (p=0.4) of bundle and control-group patients presented neurological sequelae. The only variable associated with mortality at multivariate analysis was ICU admission (HR 3.65). After adjusting for ICU admission, patients managed according with the ABM bundle had significantly lower mortality rate compared to historical controls. Conclusions: Use of a bundled protocol and antibiotics with excellent CSF penetration for the initial management of ABM in emergency department is feasible and associated with significant reduction in mortality.
Mechanisms for communicating within primary health care teams.

OBJECTIVE To explore the types of communication used within primary health care teams (PHCTs), with a particular focus on the mechanisms teams use to promote optimal clinical and administrative information sharing. DESIGN A descriptive qualitative study. SETTING Primary health care teams in Ontario between August 2004 and October 2005. PARTICIPANTS Purposive sampling was used to recruit 121 members from 16 PHCTs reflecting a range of health care professionals, including family physicians, nurse practitioners, nurses, pharmacists, dietitians, social workers, office managers, health promoters, and receptionists. METHODS Individual in-depth interviews were conducted. An iterative analysis process was used to examine the verbatim transcripts created from the interviews. Techniques of immersion and crystallization were used in the analysis. MAIN FINDINGS Analysis of the data revealed that communication occurs through formal and informal means. Formal communication included regular team meetings with agendas and meeting minutes, memorandums, computer-assisted communication, and communication logs. Informal communication methods were open and opportunistic, reflecting the traditional hallway consultation. For patient care issues, face-to-face communication was preferred. Team member attributes facilitating communication included approachability, availability, and proximity. Finally, funding issues could be an impediment to optimal communication. CONCLUSION Primary health care is experiencing demands for enhanced and efficient communication that optimizes team functioning and patient care. This study describes formal and informal mechanisms of communication currently used by PHCTs. Attributes that facilitate team communication, such as approachability, availability, and proximity of team members, were highlighted. New funding arrangements might alleviate concerns about remuneration for attendance at meetings.
A Note on Performance Limitations in Bandit Problems With Side Information

We consider a sequential adaptive allocation problem which is formulated as a traditional two armed bandit problem but with one important modification: at each time step t, before selecting which arm to pull, the decision maker has access to a random variable Xt which provides information on the reward in each arm. Performance is measured as the fraction of time an inferior arm (generating lower mean reward) is pulled. We derive a minimax lower bound that proves that in the absence of sufficient statistical "diversity" in the distribution of the covariate X, a property that we shall refer to as lack of persistent excitation, no policy can improve on the best achievable performance in the traditional bandit problem without side information.
Touch-less interaction with medical images using hand & foot gestures

Sterility restrictions in surgical settings make touch-less interaction an interesting solution for surgeons to interact directly with digital images. The HCI community has already explored several methods for touch-less interaction including those based on camera-based gesture tracking and voice control. In this paper, we present a system for gesture-based interaction with medical images based on a single wristband sensor and capacitive floor sensors, allowing for hand and foot gesture input. The first limited evaluation of the system showed an acceptable level of accuracy for 12 different hand & foot gestures; also users found that our combined hand and foot based gestures are intuitive for providing input.
Guideline on aspects of cancer‐related venous thrombosis

The guideline was drafted by a writing group identified by the Haemostasis and Thrombosis Task Force of the British Committee for Standards in Haematology (BCSH). All the authors are consultants in haematology in the UK. A search was performed of PubMed and Embase using the term ‘cancer’ combined with ‘thrombosis’, ‘treatment’, ‘prophylaxis’ and ‘clinical presentation’. The search covered articles published up until December 2014. Only human studies were included and articles not written in English were excluded. References in recent reviews were also examined. The writing group produced the draft guideline, which was subsequently revised by consensus by members of the Haemostasis and Thrombosis Task Force of the BCSH and the BCSH executive. The guideline was then reviewed by the sounding board of the British Society for Haematology (BSH). This comprises 50 or more members of the BSH who have reviewed the guidance and commented on the content and application to the UK setting. The ‘GRADE’ system was used to quote levels and grades of evidence, details of which can be found at: http://www.bcshguidelines. com/BCSH_PROCESS/EVIDENCE_LEVELS_AND_GRADES_OF_RECOMMENDATION/43_GRADE. html. The objective of this guideline is to provide healthcare professionals with clear guidance on the prevention and management of venous thromboembolism (VTE) in patients with cancer and to advise on an approach to screening for cancer in patients with unprovoked VTE in whom cancer was not initially suspected based on clinical grounds.
Structural and Functional Analysis of Domains Mediating Interaction Between the Bagpipe Homologue, Nkx3.1 and Serum Response Factor

Nkx3.1 is a member of the NK2 class of homeodomain proteins and is expressed in development, being an early marker of the sclerotome and prostate gland. It has been shown to be a critical factor for prostate differentiation and function. Previous studies suggested that Nkx3.1 interacts with Serum Response Factor (SRF) to transactivate the Smooth Muscle γ-Actin (SMGA) promoter. In studies presented here, we examined the molecular mechanisms underlying the functional synergy of these factors upon SMGA transcription. We demonstrate that full length Nkx3.1 physically interacts with SRF in the absence of DNA and that these factors are able to co-associate in cellular context using a mammalian two-hybrid system. The segment of SRF responsible for Nkx3.1 interaction was mapped to a ~30 amino acid region (AAs 142–171) at the N-terminal segment of the MADS box. Two separate regions of Nkx3.1 were found to mediate interactions with SRF. Interestingly, recognized domains of NK2 proteins, namely the TN, homeodomain DNA binding segment, and the NK2-SD do not participate in SRF interactions. One of the Nkx3.1 SRF binding domains was mapped to the N-terminal of the protein consistent with recent studies of these proteins using NMR spectroscopy by Gelmann and colleagues (1). A second SRF binding region was mapped to amino acids C-terminal to the homeodomain. Structural predictions indicate that both of the SRF interacting segments are largely hydrophobic in character and β-strand in structure. With co-transfection transcriptional analyses we found that interaction between SRF and Nkx3.1 as well as DNA binding by both factors was required for the observed transcriptional synergy. Thus our studies have identified novel protein-protein interacting domains within Nkx3.1 and SRF that operate in concert with their respective DNA binding domains to mediate functional transcriptional synergy of these factors to regulate SMGA gene activation.
Factors Associated with Citation of Internal Medicine Residency Programs for Lack of Scholarly Activity

Background: The Accreditation Council for Graduate Medical Education requires that residents demonstrate scholarly activity prior to completion of training. Purpose: To determine which factors are associated with program citation for failure to comply with the Residency Review Committee (RRC) scholarly activity requirement for internal medicine residencies. Methods: All 391 internal medicine residency program directors were surveyed in March 2002. Data were collected on program characteristics and factors (research curriculum, research director, faculty mentors, protected time for research, funding, and presence of a mandatory research requirement) that have been associated with successful resident research. Multiple logistic regression analysis identified factors associated with citation. Results: The response rate was 78%. Ten percent of respondents report having been cited for lack of demonstration of scholarly activity. Factors that reduced the odds of citation were being a university-based program, odds ratio (OR) 0.13, 95% confidence interval (CI) 0.03-0.54, p =. 005; having a greater number of residents, OR 0.95, 95% CI 0.93-0.98, p =. 001; and having funding to support resident scholarship, OR 0.39, 95% CI 0.17-0.91, p =. 03. Using multiple logistic regression analysis, having designated funding for resident scholarship was the only factor independently associated with a decreased odds of citation, OR 0.27, 95% CI 0.10-0.72, p =. 009. Conclusions: To improve compliance with the RRC requirement for scholarly activity and avoid citation, residency programs may wish to consider devoting more resources, particularly money, to support resident scholarly activity.