Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical Application of Radiolabeled RGD Peptides for PET Imaging of Integrin αvβ3

Molecular imaging for non-invasive assessment of angiogenesisis is of great interest for clinicians because of the wide-spread application of anti-angiogenic cancer therapeutics. Besides, many other interventions that involve the change of blood vessel/tumor microenvironment would also benefit from such imaging strategies. Of the imaging techniques that target angiogenesis, radiolabeled Arg-Gly-Asp (RGD) peptides have been a major focus because of their high affinity and selectivity for integrin αvβ3--one of the most extensively examined target of angiogenesis. Since the level of integrin αvβ3 expression has been established as a surrogate marker of angiogenic activity, imaging αvβ3 expression can potentially be used as an early indicator of effectiveness of antiangiogenic therapy at the molecular level. In this review, we summarize RGD-based PET tracers that have already been used in clinical trials and intercompared them in terms of radiosynthesis, dosimetry, pharmacokinetics and clinical applications. A perspective of their future use in the clinic is also provided.
Parallel Thalamic Pathways for Whisking and Touch Signals in the Rat

In active sensation, sensory information is acquired via movements of sensory organs; rats move their whiskers repetitively to scan the environment, thus detecting, localizing, and identifying objects. Sensory information, in turn, affects future motor movements. How this motor-sensory-motor functional loop is implemented across anatomical loops of the whisker system is not yet known. While inducing artificial whisking in anesthetized rats, we recorded the activity of individual neurons from three thalamic nuclei of the whisker system, each belonging to a different major afferent pathway: paralemniscal, extralemniscal (a recently discovered pathway), or lemniscal. We found that different sensory signals related to active touch are conveyed separately via the thalamus by these three parallel afferent pathways. The paralemniscal pathway conveys sensor motion (whisking) signals, the extralemniscal conveys contact (touch) signals, and the lemniscal pathway conveys combined whisking–touch signals. This functional segregation of anatomical pathways raises the possibility that different sensory-motor processes, such as those related to motion control, object localization, and object identification, are implemented along different motor-sensory-motor loops.
Differentially-Private Mining of Moderately-Frequent High-Confidence Association Rules

Association rule mining allows discovering of patterns in large data repositories, and benefits diverse application domains such as healthcare, marketing, social studies, etc. However, mining datasets that contain data about individuals may cause significant privacy breaches, and disclose sensitive information about one's health status, political orientation or alternative lifestyle. Recent research addressed the privacy threats that arise when mining sensitive data, and several techniques allow data mining with differential privacy guarantees. However, existing methods only discover rules that have very large support, i.e., occur in a large fraction of the dataset transactions (typically, more than 50%). This is a serious limitation, as numerous high-quality rules do not reach such high frequencies (e.g., rules about rare diseases, or luxury merchandise). In this paper, we propose a method that focuses on mining high-quality association rules with moderate and low frequencies. We employ a novel technique for rule extraction that combines the exponential mechanism of differential privacy with reservoir sampling. The proposed algorithm allows us to directly mine association rules, without the need to compute noisy supports for large numbers of itemsets. We provide a privacy analysis of the proposed method, and we perform an extensive experimental evaluation which shows that our technique is able to sample low- and moderate-support rules with high precision.
Plant snRNP Biogenesis: A Perspective from the Nucleolus and Cajal Bodies

Small nuclear ribonucleoproteins (snRNPs) are protein-RNA complexes composed of specific snRNP-associated proteins along with small nuclear RNAs (snRNAs), which are non-coding RNA molecules abundant in the nucleus. snRNPs mainly function as core components of the spliceosome, the molecular machinery for pre-mRNA splicing. Thus, snRNP biogenesis is a critical issue for plants, essential for the determination of a cell's activity through the regulation of gene expression. The complex process of snRNP biogenesis is initiated by transcription of the snRNA in the nucleus, continues in the cytoplasm, and terminates back in the nucleus. Critical steps of snRNP biogenesis, such as chemical modification of the snRNA and snRNP maturation, occur in the nucleolus and its related sub-nuclear structures, Cajal bodies. In this review, I discuss roles for the nucleolus and Cajal bodies in snRNP biogenesis, and a possible linkage between the regulation of snRNP biogenesis and plant development and environmental responses.
Understanding the Literacy Difficulties of Students with Asperger's Syndrome in Middle Years' Classrooms

Among the students in Australian classrooms who are experiencing learning difficulties are increasing numbers of children who have been diagnosed with Asperger's syndrome. Although the general cognitive and language abilities of these students are comparable with most of their peers, they experience significant difficulties with social communication, social interactions and social-emotional/behavioural functioning. Despite indications that there are features inherent in Asperger's syndrome that are likely to have a negative effect on the development of advanced literacy skills, studies to date have primarily focused on social-emotional/behavioural challenges. Without effective literacy skills, however, students' access to educational and career opportunities may be curtailed. This article reviews features of Asperger's syndrome that appear to have a negative impact upon the development of advanced literacy skills and suggests ways in which inclusive classroom teachers could support the development of their learners.
Scalable face image retrieval with identity-based quantization and multi-reference re-ranking

State-of-the-art image retrieval systems achieve scalability by using bag-of-words representation and textual retrieval methods, but their performance degrades quickly in the face image domain, mainly because they 1) produce visual words with low discriminative power for face images, and 2) ignore the special properties of the faces. The leading features for face recognition can achieve good retrieval performance, but these features are not suitable for inverted indexing as they are high-dimensional and global, thus not scalable in either computational or storage cost. In this paper we aim to build a scalable face image retrieval system. For this purpose, we develop a new scalable face representation using both local and global features. In the indexing stage, we exploit special properties of faces to design new component-based local features, which are subsequently quantized into visual words using a novel identity-based quantization scheme. We also use a very small hamming signature (40 bytes) to encode the discriminative global feature for each face. In the retrieval stage, candidate images are firstly retrieved from the inverted index of visual words. We then use a new multi-reference distance to re-rank the candidate images using the hamming signature. On a one-millon face database, we show that our local features and global hamming signatures are complementary — the inverted index based on local features provides candidate images with good recall, while the multi-reference re-ranking with global hamming signature leads to good precision. As a result, our system is not only scalable but also outperforms the linear scan retrieval system using the state-of-the-art face recognition feature in term of the quality.
Stress-induced tRNA-derived RNAs: a novel class of small RNAs in the primitive eukaryote Giardia lamblia

Giardia lamblia is an early diverging and evolutionarily successful protozoan as it can enter into a dormant cyst stage from a vegetative trophozoite. During dormant stage, its metabolic rate decreases dramatically. However, to date, the regulatory molecules participating in the initiation and maintenance of this process have not been fully investigated. In this study, we have identified a class of abundant small RNAs named sitRNAs, which are ∼46 nucleotides in length and accumulate in G. lamblia encysting cultures. Remarkably, they are derived from the 3′ portion of fully matured tRNAs by cleavage of the anticodon left arm, with the 3′ terminal CCA triplex still connected. During differentiation, only a limited portion of mature tRNAs is cleaved, but this cleavage occurs almost in the entire tRNA family. sitRNAs begin to accumulate as early as 3 h after initiation of encystation and are maintained at a relatively stable level during the whole process, exhibiting an expression peak at around 24 hr. Our studies further show that sitRNAs can be induced by several other stress factors, and in the case of serum deprivation, both tRNAs and sitRNAs degrade rapidly, with the accumulation of tRNA being halved. Our results may provide new insight into a novel mechanism for stressed G. lamblia to regulate gene expression globally.
Trust, conflict and cooperative behaviour: considering reciprocity within organizations

Purpose – In this introduction of the special issue “Trust, conflict and cooperative behaviour” the focus of the special issue is introduced: because al lot of attitudinal and behavioural employees' outcomes are based on reciprocity, they should be examined as a characteristic of relationships instead of a characteristic of employees.Design/methodology approach – On a theoretical level reciprocity within organizations is considered by means of the social embeddedness approach and by means of leader member exchange.Findings – Although reciprocity in relationships is well recognised in the academic literature seemingly little empirical work has been conducted on reciprocity in manager‐subordinate and subordinate‐subordinate relationships.Originality/value – In this special issue, we try to fill in this gap and focus on the reciprocity within relationships to explain trust, conflict and cooperative behaviour within organisations.
Analysis of the Native Quaternary Structure of Vanilloid Receptor 1* 210

Vanilloid receptor subtype 1 (VR1) is a ligand-gated channel that can be activated by capsaicin and other vanilloids as well as by protons and heat. In the present study, we have analyzed the oligomeric state of VR1. Co-immunoprecipitation of differently tagged VR1 molecules indicated that VR1 can form oligomers. Using two different heterologous VR1 expression systems as well as endogenous VR1 expressed in dorsal root ganglion cells, we analyzed oligomer formation using perfluoro-octanoic acid polyacrylamide gel electrophoresis. Results were confirmed both with chemical cross-linking agents as well as through endogenous cross-linking mediated by transglutaminase. Our results clearly show that VR1 forms multimers in each of the expression systems with a homotetramer as a predominant form. The oligomeric structure of VR1 may contribute to the complexity of VR1 pharmacology. Finally, differences in glycosylation between the systems were observed, indicating the need for caution in the use of the heterologous expression systems for analysis of VR1 properties.
Retinal function loss after monocarboxylate transport inhibition.

PURPOSE To test the proposal that inhibiting monocarboxylate transport in the rat retina results in altered retinal function measured using the electroretinogram (ERG) and to evaluate the efficacy of exogenous metabolic substrates to restore any functional deficit. METHODS Full-field white-flash ERGs were measured after monocarboxylate transport inhibition with intravitreal injection of alpha-cyano-4-hydroxycinnamic acid (4-CIN, 10 mM), and functional recovery was assessed after the introduction of various exogenous metabolic substrates (10 mM): lactate, pyruvate, alpha-ketoglutarate, alanine, succinate, and glutamine. The efficacy of glutamine as a metabolic substrate was also considered in the presence of phosphate-activated glutaminase inhibition (6-diazo-5-oxo-norleucin, 10 mM) or aminotransferase inhibition (aminooxyacetic acid, 10 mM). Pyruvate and alanine recovery was also assessed after aminooxyacetic acid application. RESULTS 4-CIN application resulted in an increased phototransduction amplitude but a mild reduction of gain. A greater reduction of postreceptoral b-wave and oscillatory potential amplitudes (80%) was observed, along with delayed implicit times (35 ms). Partial recovery of b-wave amplitudes was achieved with exogenous lactate (24%), pyruvate (27%), alpha-ketoglutarate (27%), alanine (25%), and succinate (26%), whereas glutamine provided 62% recovery. However, none of the substrates improved phototransduction gain. Both 6-diazo-5-oxo-norleucin and aminooxyacetic acid completely suppressed the glutamine-induced b-wave recovery. Aminooxyacetic acid also abolished the b-wave recovery from 4-CIN afforded by pyruvate and alanine. CONCLUSIONS The greater loss of the b-wave and oscillatory potentials may reflect preferential routing of amino acid carbon skeletons to oxidative metabolic pathways, which in turn reduces glutamate availability for neurotransmission between photoreceptors and ON-bipolar cells. The reduction in log S provides evidence that inhibition of monocarboxylate transport produced some metabolic dysfunction in the rat.
Role of T-Type Calcium Current in Identified D-Hair Mechanoreceptor Neurons Studied In Vitro

Different subsets of dorsal root ganglion (DRG) mechanoreceptors transduce low- and high-intensity mechanical stimuli. It was shown recently that, in vivo, neurotrophin-4 (NT-4)-dependent D-hair mechanoreceptors specifically express a voltage-activated T-type calcium channel (Cav3.2) that may be required for their mechanoreceptive function. Here we show that D-hair mechanoreceptors can be identified in vitro by a rosette-like morphology in the presence of NT-4 and that these rosette neurons are almost all absent in DRG cultures taken from NT-4 knock-out mice. In vitro identification of the D-hair mechanoreceptor allowed us to explore the electrophysiological properties of these cells. We demonstrate that the T-type Cav3.2 channel induced slow membrane depolarization that contributes to lower the voltage threshold for action potential generation and controls spike latency after stimulation of D-hair mechanoreceptors. Indeed, the properties of the T-type amplifier are particularly well suited to explain the high sensitivity of D-hair mechanoreceptors to slowly moving stimuli.
Performance effects of architectural complexity in the Intel 432

The Intel 432 is noteworthy as an architecture incorporating a large amount of functionality that most other systems perform by software. It has, in effect, “migrated” this functionality from the software into the microcode and hardware. The benefits of functional migration have recently been a subject of intense controversy, with critics claiming that a complex architecture is inherently less efficient than a simple architecture with good software support. This paper examines the performance impact of the incorporation of several kinds of functionality into the Intel 432. Among these are the addressing structure, the caches, instruction alignment, the buses, and the way that garbage collection is handled. A set of several benchmarks is used to quantify the performance effect of each of these decisions. The results indicate that the 432 could have been speeded up very significantly if a small number of implementation decisions had been made differently, and if incrementally better technology had been used in its construction. Even with these modifications, however, the 432 would still have only one-fourth to one times the speed of its contemporaries. These figures may represent the real cost of the 432's style of object-based programming environment.
A Three-Phase ACDC High Step-up Converter for Microscale Windpower Generation Systems

In this paper, a three-phase AC-DC high step-up converter is developed for application to microscale wind-power generation systems. Such an AC-DC boost converter prossessess the property of the single-switch high step-up DC-DC structure. For power factor correction, the advanced half-stage converter is operated under the discontinuous conduction mode (DCM). Simulatanously, to achieve a high step-up voltage gain, the back half-stage functions in the continuous conduction mode (CCM). A high voltage gain can be obtained by use of an output-capacitor mass and a coupled inductor. Compared to the output voltage, the voltage stress is decreased on the switch. To lessen the conducting losses, a low rated voltage and small conductive resistance MOSFETs are adopted. In addition, the coupled inductor retrieves the leakage-inductor energy. The operation principle and steady-state behavior are analyzed, and a prototype hardware circuit is realized to verify the performance of the proposed converter.
Use of Antiplatelet Agents Is Associated With Intraplaque Hemorrhage on Carotid Magnetic Resonance Imaging: The Plaque at Risk Study

Background and Purpose— Intraplaque hemorrhage (IPH), visualized by magnetic resonance imaging, has shown to be associated with the risk of stroke in patients with carotid artery stenosis. The mechanisms of IPH development are poorly understood. In this study, we investigated the association between clinical patient characteristics and carotid IPH on high-resolution magnetic resonance imaging. Methods— Patients participate in the Plaque at Risk (PARISK) study. This prospective, multicenter cohort study included patients with recent amaurosis fugax, hemispheric transient ischemic attack, or nondisabling stroke in the internal carotid artery territory and an ipsilateral carotid stenosis of <70%, who were not scheduled for carotid revascularization procedure. One hundred patients, recruited between 2010 and 2012, underwent a 3-T high-resolution carotid magnetic resonance imaging. We documented clinical patient characteristics and performed multivariable logistic regression analysis to investigate their association with IPH. Results— IPH was observed in 45 patients (45%) in 1 or both carotid arteries. Male sex and the use of antiplatelet agents before the index event were associated with IPH in univariable analysis. In a multivariable analysis, only previous use of antiplatelet agents was significantly associated with IPH (odds ratio, 2.71; 95% confidence interval, 1.12–6.61). Risk factors of atherosclerotic arterial disease, including a history of symptomatic arterial diseases, were not associated with IPH. Conclusions— In this cohort of 100 patients with recently symptomatic carotid stenosis, the previous use of antiplatelet agents is associated with carotid IPH on magnetic resonance imaging. Antiplatelet therapy may increase the risk of IPH, but our findings need to be confirmed in larger patient cohorts. The implications for risk stratification remain to be determined.
Carry-over effects of the social environment on future divorce probability in a wild bird population

Initial mate choice and re-mating strategies (infidelity and divorce) influence individual fitness. Both of these should be influenced by the social environment, which determines the number and availability of potential partners. While most studies looking at this relationship take a population-level approach, individual-level responses to variation in the social environment remain largely unstudied. Here, we explore carry-over effects on future mating decisions of the social environment in which the initial mating decision occurred. Using detailed data on the winter social networks of great tits, we tested whether the probability of subsequent divorce, a year later, could be predicted by measures of the social environment at the time of pairing. We found that males that had a lower proportion of female associates, and whose partner ranked lower among these, as well as inexperienced breeders, were more likely to divorce after breeding. We found no evidence that a female's social environment influenced the probability of divorce. Our findings highlight the importance of the social environment that individuals experience during initial pair formation on later pairing outcomes, and demonstrate that such effects can be delayed. Exploring these extended effects of the social environment can yield valuable insights into processes and selective pressures acting upon the mating strategies that individuals adopt.
Exploring the reasons for delay in treatment of oral cancer.

BACKGROUND Oral cancer continues to be diagnosed and treated at a late stage, which has a negative effect on outcomes. This study identified and quantified delays in diagnosis and treatment. METHODS The authors conducted a study that included all new patients seen in the Department of Oral and Maxillofacial Surgery, University of California, San Francisco, between 2003 and 2007 who had a diagnosis of squamous cell carcinoma of the oral cavity. They identified the time intervals for six stages, beginning with the time at which patients first became aware of symptoms and ending with the time at which definitive treatment began. RESULTS The total time from patients' first sign or symptoms to commencement of treatment was a mean of 205.9 days (range, 52-786 days). The longest delay was from the time symptoms first appeared to the initial visit to a health care professional (mean time, 104.7 days; range, 0-730 days). CONCLUSIONS Health care professionals need to place greater emphasis on patient education to encourage early self-referrals. CLINICAL IMPLICATIONS Patients should be encouraged to visit a health care professional when signs or symptoms of oral cancer first develop.
Newborn Neurons Search for Meaning

Some brain regions are replenished with new cells throughout life, but researchers aren9t sure what the newcomers contribute to the behaviors those brain regions control, which include singing, smelling, and learning. A number of experiments, including one on page 117 that identifies prolactin, a hormone that increases during pregnancy, as a neurogenesis trigger, have suggested that the new neurons might boost learning. The evidence has been correlational, however, and it doesn9t all agree.
Analyzing Frequent Sequential Patterns of Learning Behaviors in Concept Mapping

Computer-based concept mapping learning environments can produce large amounts of data on student interactions. The ability to automatically extract common interaction patterns and distinguish between effective and ineffective interactions creates opportunities for researchers to calibrate feedback and assistance to better support student learning. In this paper, we present an exploratory workflow that assesses and compares student learning behaviors with concept maps. This workflow employs a sequential pattern mining technique to classify interaction patterns among students and determine specific behavior patterns that lead to better learning outcomes.