Miracle-dz/UniFAR-FTUs huggingface dataset:
Exposure to continuous political violence: rational and experiential thinking styles, coping styles and post traumatic stress symptoms

Cognitive style is considered an important determinant of individual behavior. The aim of the present study was to examine the relations between rational and experiential thinking styles, coping styles and Post Traumatic Stress (PTS) symptoms among civilians exposed to continuous and ongoing exposure to political violence. Three-hundred and thirty-two Israeli adult citizens living in the south region of Israel reported on their experiences of exposure to political violence as well as level of PTS, coping styles, and preference toward rational and experiential processing style. Results showed that low rational thinking was related with elevated PTS, both directly and indirectly through the mediation of high emotion-focused coping. The findings suggest that rational thinking may serve as a protective factor against stress related to chronic exposure to political violence; conversely, a preference for low rationality may be a risk factor.
Expression profile of HERVs and inflammatory mediators detected in nasal mucosa as a predictive biomarker of COVID-19 severity

Introduction Our research group and others demonstrated the implication of the human endogenous retroviruses (HERVs) in SARS-CoV-2 infection and their association with disease progression, suggesting HERVs as contributing factors in COVID-19 immunopathology. To identify early predictive biomarkers of the COVID-19 severity, we analyzed the expression of HERVs and inflammatory mediators in SARS-CoV-2-positive and -negative nasopharyngeal/oropharyngeal swabs with respect to biochemical parameters and clinical outcome. Methods Residuals of swab samples (20 SARS-CoV-2-negative and 43 SARS-CoV-2-positive) were collected during the first wave of the pandemic and expression levels of HERVs and inflammatory mediators were analyzed by qRT-Real time PCR. Results The results obtained show that infection with SARS-CoV-2 resulted in a general increase in the expression of HERVs and mediators of the immune response. In particular, SARS-CoV-2 infection is associated with increased expression of HERV-K and HERV-W, IL-1β, IL-6, IL-17, TNF-α, MCP-1, INF-γ, TLR-3, and TLR-7, while lower levels of IL-10, IFN-α, IFN-β, and TLR-4 were found in individuals who underwent hospitalization. Moreover, higher expression of HERV-W, IL-1β, IL-6, IFN-α, and IFN-β reflected the respiratory outcome of patients during hospitalization. Interestingly, a machine learning model was able to classify hospitalized vs not hospitalized patients with good accuracy based on the expression levels of HERV-K, HERV-W, IL-6, TNF-a, TLR-3, TLR-7, and the N gene of SARS-CoV-2. These latest biomarkers also correlated with parameters of coagulation and inflammation. Discussion Overall, the present results suggest HERVs as contributing elements in COVID-19 and early genomic biomarkers to predict COVID-19 severity and disease outcome.
Use of the superficial inferior epigastric vein in breast reconstruction with a deep inferior epigastric artery perforator flap

Background Autologous breast reconstruction is highly regarded in reconstructive surgery after mastectomy. DIEP flap reconstruction represents the gold standard for autologous breast reconstruction. The major advantages of DIEP flap reconstruction are its adequate volume, large vascular caliber and pedicle length. Despite reliable anatomy, there are procedures where the plastic surgeon's creativity is required, not only to shape the new breast, but also to overcome microsurgical challenges. An important tool in these cases is the superficial epigastric vein (SIEV). Methods 150 DIEP flap procedures performed between 2018 and 2021 were retrospectively evaluated for SIEV use. Intraoperative and postoperative data were analyzed. Rate of anastomosis revision, total and partial flap loss, fat necrosis and donor site complications were evaluated. Results In a total of 150 breast reconstructions with a DIEP flap performed in our clinic, the SIEV was used in 5 cases. The indication for using the SIEV was to improve the venous drainage of the flap or as a graft to reconstruct the main artery perforator. Among the 5 cases, no flap loss occurred. Conclusions Use of the SIEV is an excellent method to expand the microsurgical options in breast reconstruction with DIEP flap surgery. It provides a safe and reliable procedure to improve venous outflow in cases of inadequate outflow from the deep venous system. The SIEV could also provide a very good option for fast and reliable application as an interposition device in case of arterial complications.
Personalization strategies in digital mental health interventions: a systematic review and conceptual framework for depressive symptoms

Introduction Personalization is a much-discussed approach to improve adherence and outcomes for Digital Mental Health interventions (DMHIs). Yet, major questions remain open, such as (1) what personalization is, (2) how prevalent it is in practice, and (3) what benefits it truly has. Methods We address this gap by performing a systematic literature review identifying all empirical studies on DMHIs targeting depressive symptoms in adults from 2015 to September 2022. The search in Pubmed, SCOPUS and Psycinfo led to the inclusion of 138 articles, describing 94 distinct DMHIs provided to an overall sample of approximately 24,300 individuals. Results Our investigation results in the conceptualization of personalization as purposefully designed variation between individuals in an intervention's therapeutic elements or its structure. We propose to further differentiate personalization by what is personalized (i.e., intervention content, content order, level of guidance or communication) and the underlying mechanism [i.e., user choice, provider choice, decision rules, and machine-learning (ML) based approaches]. Applying this concept, we identified personalization in 66% of the interventions for depressive symptoms, with personalized intervention content (32% of interventions) and communication with the user (30%) being particularly popular. Personalization via decision rules (48%) and user choice (36%) were the most used mechanisms, while the utilization of ML was rare (3%). Two-thirds of personalized interventions only tailored one dimension of the intervention. Discussion We conclude that future interventions could provide even more personalized experiences and especially benefit from using ML models. Finally, empirical evidence for personalization was scarce and inconclusive, making further evidence for the benefits of personalization highly needed. Systematic Review Registration Identifier: CRD42022357408.
[18F]AlF-NOTA-ADH-1: A new PET molecular radiotracer for imaging of N-cadherin-positive tumors

Background The cell adhesion molecule (CAM) N-cadherin has become an important target for tumor therapy. The N-cadherin antagonist, ADH-1, exerts significant antitumor activity against N-cadherin-expressing cancers. Methods In this study, [18F]AlF-NOTA-ADH-1 was radiosynthesized. An in vitro cell binding test was performed, and the biodistribution and micro-PET imaging of the probe targeting N-cadherin were also studied in vivo. Results Radiolabeling of ADH-1 with [18F]AlF achieved a yield of up to 30% (not decay-corrected) with a radiochemical purity of >97%. The cell uptake study showed that Cy3-ADH-1 binds to SW480 cells but weakly binds to BXPC3 cells in the same concentration range. The biodistribution results demonstrated that [18F]AlF-NOTA-ADH-1 had a good tumor/muscle ratio (8.70±2.68) in patient-derived xenograft (PDX) tumor xenografts but a lower tumor/muscle ratio (1.91±0.69) in SW480 tumor xenografts and lowest tumor/muscle ratio (0.96±0.32) in BXPC3 tumor xenografts at 1 h post-injection (p.i.) These findings were in accordance with the immunohistochemistry results. The micro PET imaging results revealed good [18F]AlF-NOTA-ADH-1 tumor uptake in pancreatic cancer PDX xenografts with strong positive N-calcium expression, while lower tumor uptake in SW480 xenografts with positive expression of N-cadherin, and significantly lower tumor uptake in BXPC3 xenografts with low expression of N-cadherin, which was consistent with the biodistribution and immunohistochemistry results. The N-cadherin-specific binding of [18F]AlF-NOTA-ADH-1 was further verified by a blocking experiment involving coinjection of a non radiolabeled ADH-1 peptide, resulting in a significant reduction in tumor uptake in PDX xenografts and SW480 tumor. Conclusion [18F]AlF-NOTA-ADH-1 was successfully radiosynthesized, and Cy3-ADH-1 showed favorable N-cadherin-specific targeting ability by in vitro data. The biodistribution and microPET imaging of the probe further showed that [18F]AlF-NOTA-ADH-1 could discern different expressions of N-cadherin in tumors. Collectively, the findings demonstrated the potential of [18F]AlF-NOTA-ADH-1 as a PET imaging probe for non-invasive evaluation of the N-cadherin expression in tumors.
Advances in omics research on peanut response to biotic stresses

Peanut growth, development, and eventual production are constrained by biotic and abiotic stresses resulting in serious economic losses. To understand the response and tolerance mechanism of peanut to biotic and abiotic stresses, high-throughput Omics approaches have been applied in peanut research. Integrated Omics approaches are essential for elucidating the temporal and spatial changes that occur in peanut facing different stresses. The integration of functional genomics with other Omics highlights the relationships between peanut genomes and phenotypes under specific stress conditions. In this review, we focus on research on peanut biotic stresses. Here we review the primary types of biotic stresses that threaten sustainable peanut production, the multi-Omics technologies for peanut research and breeding, and the recent advances in various peanut Omics under biotic stresses, including genomics, transcriptomics, proteomics, metabolomics, miRNAomics, epigenomics and phenomics, for identification of biotic stress-related genes, proteins, metabolites and their networks as well as the development of potential traits. We also discuss the challenges, opportunities, and future directions for peanut Omics under biotic stresses, aiming sustainable food production. The Omics knowledge is instrumental for improving peanut tolerance to cope with various biotic stresses and for meeting the food demands of the exponentially growing global population.
Analysis of convergence of linkage and association studies in autism spectrum disorders

Autism spectrum disorder (ASD) is a clinically and genetically heterogeneous group of pervasive neurodevelopmental disorders with a strong hereditary component. Although genome-wide linkage studies (GWLS) and [genome-wide association studies (GWAS)] have previously identified hundreds of ASD risk gene loci, the results remain inconclusive. In this study, a genomic convergence approach of GWAS and GWLS for ASD was implemented for the first time in order to identify genomic loci supported by both methods. A database with 32 GWLS and five GWAS for ASD was created. Convergence was quantified as the proportion of significant GWAS markers located within linked regions. Convergence was not found to be significantly higher than expected by chance (z-test = 1,177, P = 0,239). Although convergence is supportive of genuine effects, the lack of agreement between GWLS and GWAS is also indicative that these studies are designed to answer different questions and are not equally well suited for deciphering the genetics of complex traits.
Cultured Skin Autograft in Subtotal Pediatric Scalp Avulsion

ABSTRACT Pediatric scalp avulsions represent a reconstructive challenge because of the unique features of scalp tissue. When microsurgical reimplantation is not feasible, alternative approaches such as skin grafting, free flap transfer with latissimus flap, or tissue expansion are considered. Generally, there is no consensus regarding management of this trauma, and, oftentimes, multiple reconstructive techniques may be needed for definitive coverage. This case study describes the reconstruction of a pediatric subtotal scalp avulsion using a dermal regeneration template and novel autologous homologous skin construct. This case was complicated by the absence of original tissue for reimplantation, excessive size of the defect relative to body habitus, and family concerns for future hair-bearing function. The reconstruction successfully provided definitive coverage and significantly reduced the size of the donor site and associated compilations. However, the hair-bearing potential of the tissue has yet to be determined.
Internal and External Bremsstrahlung in Connection with the Beta Decay of S 35

The internal bremsstrahlung, emitted in the $\ensuremath{\beta}$ decay of ${\mathrm{S}}^{35}$, was investigated with a NaI scintillation spectrometer. Neither the shape of the spectral distribution nor the absolute yield was found to agree with theory. At 50 kev the experimental photon yield was 65 percent greater than the theoretical. At 100 kev it was even 180 percent greater. The total photon energy yield per $\ensuremath{\beta}$ decay, 2.23\ifmmode\times\else\texttimes\fi{}${10}^{\ensuremath{-}5}$ ${\mathit{mc}}^{2}$, was 35 percent greater than the calculated value.The external bremsstrahlung, emitted when the $\ensuremath{\beta}$ particles from ${\mathrm{S}}^{35}$ were stopped in matter, was also investigated with the same apparatus. With elements of low atomic number the experimental values agreed with those calculated. In experiments using elements of higher atomic numbers, however, the experimental values differed widely from those calculated, the difference increasing with the atomic number. Thus, for lead at 50 kev the experimental value was 60 percent greater than the theoretical, and at 100 kev it was 170 percent greater.
Comparing the Incomparable? Issues of Lacking Common Support, Functional-Form Misspecification, and Insufficient Sample Size in Decompositions

Decompositions make it possible to investigate whether gaps between groups in certain outcomes would remain if groups had comparable characteristics. In practice, however, such a counterfactual comparability is difficult to establish in the presence of lacking common support, functional-form misspecification, and insufficient sample size. In this article, the authors show how decompositions can be undermined by these three interrelated issues by comparing the results of a regression-based Kitagawa-Blinder-Oaxaca decomposition and matching decompositions applied to simulated and real-world data. The results show that matching decompositions are robust to issues of common support and functional-form misspecification but demand a large number of observations. Kitagawa-Blinder-Oaxaca decompositions provide consistent estimates also for smaller samples but require assumptions for model specification and, when common support is lacking, for model-based extrapolation. The authors recommend that any decomposition benefits from using a matching approach first to assess potential problems of common support and misspecification.
Artificial Neural Network and Latent Semantic Analysis for Adverse Drug Reaction Detection

Adverse drug reactions (ADR) are important information for verifying the view of the patient on a particular drug. Regular user comments and reviews have been considered during the data collection process to extract ADR mentions, when the user reported a side effect after taking a specific medication. In the literature, most researchers focused on machine learning techniques to detect ADR. These methods train the classification model using annotated medical review data. Yet, there are still many challenging issues that face ADR extraction, especially the accuracy of detection. The main aim of this study is to propose LSA with ANN classifiers for ADR detection. The findings show the effectiveness of utilizing LSA with ANN in extracting ADR.
Physics and Kinematics of the Extended Narrow Line Region of Three AGN

ln this work I will study the physicaland kinematic properties of the Extended Narrow Line Region (ENLR) of three Active Galactic Nuclei (AGNs). The ENLR is a structure which can be observed in nearby Seyfert galaxies and it consists of gas ionized by the central AGN. lt is characterized by a complex kinematics. ln this study I will use high resolution spectra, acquired with MagE echelle spectrograph
Miniaturized High Gain Broadband 16‐Element MIMO Array Using Planar Artificial Magnetic Conductor With Enhanced Isolation for WLAN/WiMAX Applications

A low‐profile 16‐element printed dipole antenna (PDA) array backed by a planar artificial magnetic conductor (AMC) is introduced for multiple‐input multiple‐output (MIMO) wireless communications. The proposed 16‐element MIMO array loaded by a 13 × 13 AMC reflector with various polarized directions exhibits a low‐profile wideband structure, which includes the broad measured bandwidths from 4.25 to 7.25 GHz with increased gains (>8 dBi) and high efficiency. The high isolation between the 16 elements with diverse polarizations is larger than 27 dB and reaches 67 dB over the operating band for MIMO systems. The suggested PDA with a microstrip V‐shaped dipole excited by a V‐shaped microstrip feedline is used to expand the broad simulated band spanning 5.34–6.70 GHz (S11 ≤ −10 dB). Moreover, the suggested 13 × 13 planar fractal AMC reflector is loaded into the PDA array to exhibit a reflection coefficient, S11, of less than −10 dB across the band of 4.26–6.90 GHz for wireless local area network and worldwide interoperability for microwave access applications. The proposed design with AMC compared to the design without AMC exhibits a size reduction of 50.3%, increased gain up to 8.2 dBi, and excellent impedance matching with unidirectional radiation patterns. The novel AMC unit cell is realized based on the planar patch with inserted slots to operate at 6.10 GHz with an AMC band spanning 5.15–7.10 GHz (32%).
The combination of DNA methylation and positive regulation of anthocyanin biosynthesis by MYB and bHLH transcription factors contributes to the petal blotch formation in Xibei tree peony

Abstract Xibei tree peony is a distinctive cultivar group that features red–purple blotches in petals. Interestingly, the pigmentations of blotches and non-blotches are largely independent of one another. The underlying molecular mechanism had attracted lots of attention from investigators, but was still uncertain. Our present work demonstrates the factors that are closely related to blotch formation in Paeonia rockii ‘Shu Sheng Peng Mo’. Non-blotch pigmentation is prevented by the silencing of anthocyanin structural genes, among which PrF3H, PrDFR, and PrANS are the three major genes. We characterized two R2R3-MYBs as the key transcription factors that control the early and late anthocyanin biosynthetic pathways. PrMYBa1, which belongs to MYB subgroup 7 (SG7) was found to activate the early biosynthetic gene (EBG) PrF3H by interacting with SG5 member PrMYBa2 to form an ‘MM’ complex. The SG6 member PrMYBa3 interacts with two SG5 (IIIf) bHLHs to synergistically activate the late biosynthetic genes (LBGs) PrDFR and PrANS, which is essential for anthocyanin accumulation in petal blotches. The comparison of methylation levels of the PrANS and PrF3H promoters between blotch and non-blotch indicated a correlation between hypermethylation and gene silencing. The methylation dynamics of PrANS promoter during flower development revealed a potential early demethylating reaction, which may have contributed to the particular expression of PrANS solely in the blotch area. We suggest that the formation of petal blotch may be highly associated with the cooperation of transcriptional activation and DNA methylation of structural gene promoters.
Elements of X-ray diffraction

Intended to acquaint the reader with the theory of x-ray diffraction, the experimental methods involved, and the main applications. The book is a collection of principles and methods stressing X-ray diffraction rather than metallurgy. The book is written entirely in terms of the Bragg law and can be read without any knowledge of the reciprocal lattice. It is divided into three main parts— Fundamentals; experimental methods; and applications. Designed for beginners, not as a reference tool for the advanced reader.
Magneto-induced Fano-like cavity interference in three-dimensional metamaterials

Fano-like cavity interference due to magneto-inductive coupling in metamaterial structure is demonstrated via a double Fabry–Perot cavity (DFPC) that consists of stacked multi-layered resonators. The induced magnetic field based destructive interference is observed in the transmission response of the DFPC system, which exhibits the Fano line shaped resonance. The retrieved real and imaginary parts of effective permeability and permittivity indicate strong magneto-induced dispersion with a group delay leading to the slow light effect. This finding provides an interesting mechanism to excite Fano resonances in metamaterial systems via magnetic interaction between resonators, which may enable new devices for slow light and sensing applications.
On the Choice of Nugget in Kriging Modeling for Deterministic Computer Experiments

Kriging is commonly used for developing emulators as surrogates for computationally intensive simulations. One difficulty with kriging is the potential numerical instability in the computation of the inverse of the covariance matrix, which can lead to large variability and poor performance of the kriging predictor. First, we study some causes of ill-conditioning in kriging. We then study the use of nugget in kriging to overcome the numerical instability. Some asymptotic results on its interpolation bias and mean squared prediction errors are presented. Finally, we study the choice of the nugget parameter based on some algebraic lower bounds and use of a regularizing trace. A simulation study is performed to show the differences between kriging with and without nugget and to demonstrate the advantages of the former. This article has supplementary materials online.
Omics analyses in citrus reveal a possible role of RNA translation pathways and Unfolded Protein Response regulators in the tolerance to combined drought, high irradiance, and heat stress

Abstract Environmental changes derived from global warming and human activities increase the intensity and frequency of stressful conditions for plants. Multiple abiotic factors acting simultaneously enhance stress pressure and drastically reduce plant growth, yield, and survival. Stress combination causes a specific stress situation that induces a particular plant response different to the sum of responses to the individual stresses. Here, by comparing transcriptomic and proteomic profiles to different abiotic stress combinations in two citrus genotypes, Carrizo citrange (Citrus sinensis × Poncirus trifoliata) and Cleopatra mandarin (Citrus reshni), with contrasting tolerance to different abiotic stresses, we revealed key responses to the triple combination of heat stress, high irradiance and drought. The specific transcriptomic response to this stress combination in Carrizo was directed to regulate RNA metabolic pathways and translation processes, potentially conferring an advantage with respect to Cleopatra. In addition, we found endoplasmic reticulum stress response as common to all individual and combined stress conditions in both genotypes and identified the accumulation of specific groups of heat shock proteins (HSPs), such as small HSPs and HSP70s, and regulators of the unfolded protein response, BiP2 and PDIL2-2, as possible factors involved in citrus tolerance to triple stress combination. Taken together, our findings provide new insights into the acclimation process of citrus plants to multiple stress combination, necessary for increasing crop tolerance to the changing climatic conditions.