Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of high-resolution LM for urban air pollution episodes

Introduction Conclusions References Tables Figures Back Close Abstract Introduction Conclusions References Tables Figures Back Close Abstract The operational numerical weather prediction model Lokalmodell LM with 7 km horizontal resolution was evaluated for simulations of the meteorological conditions during observed urban air pollution episodes. The resolution was increased to experimental 2.8 km and 1.1 km resolution by one-way interactive nesting without introducing urban-5 isation of physiographic parameters or parameterisations. The episodes examined are two severe winter inversion-induced episodes in Helsinki in December 1995 and Oslo in January 2003, three suspended dust episodes in spring and autumn in Helsinki and Oslo, and a late-summer photochemical episode in the Valencia area. The evaluation was basically performed against observations and radiosoundings and focused on the 10 LM skill at forecasting the key meteorological parameters characteristic for the specific episodes. These included temperature inversions, atmospheric stability and low wind speed for the Scandinavian episodes and the development of mesoscale recirculations in the Valencia area. LM forecasts often improved due to higher model resolution especially in mountainous areas like Oslo and Valencia where features depending on 15 topography like temperature, wind fields and mesoscale valley circulations were better described. At coastal stations especially in Helsinki, forecast gains were due to the improved physiographic parameters (land fraction, soil type, or roughness length). The Helsinki and Oslo winter inversions with extreme nocturnal inversion strengths of 18 • C were not sufficiently predicted with all LM resolutions. In Helsinki, overpredic-20 tion of surface temperatures and low-level wind speeds basically led to underpredicted inversion strength. In the Oslo episode, the situation was more complex involving erroneous temperature advection and mountain-induced effects for the higher resolutions. Possible explanations include the influence of the LM treatment of snow cover, sea ice and stability-dependence of transfer and diffusion coefficients. The LM simulations 25 distinctly improved for winter daytime and nocturnal spring and autumn inversions and showed good skill at forecasting further episode-relevant meteorological parameters. Abstract Introduction Conclusions References Tables Figures Back Close Full Screen / Esc Print Version Interactive Discussion EGU mesoscale circulation patterns and showed that the LM succeeds well in describing all the qualitative features observed in the region. LM performance in forecasting the examined episodes thus depends on the key episode characteristics and also the season of the year with a need to improve model performance in very stable inversion conditions not only for urban simulations.
MIRs are classic, tRNA-derived SINEs that amplified before the mammalian radiation

Short Interspersed Nucleotide Elements (SINEs) are highly abundant in mammalian genomes. The term SINE has come to be restricted to short retroposons with internal RNA polymerase III promoter sites in a region derived from a structural RNA (usually a tRNA). Here we describe a novel, 260 bp tRNA-derived SINE, some fragments of which have been noted before to be repetitive in mammalian DNA. Unlike previously reported SINEs, which are restricted to closely related species, copies of this element can be found in all mammalian genomes, including marsupials. It is therefore called MIR for mammalian-wide interspersed repeat. Their high divergence and their presence at orthologous sites in different mammals indicate that MIRs, at least in part, amplified before the mammalian radiation. Next to Alu, MIRs are the most common interspersed repeat in primates with an estimated 300,000 copies still discernible, which account for 1 to 2% of our DNA. Interestingly, a small, central region of MIR appears to be much better conserved in the genomic copies than the rest of the sequence.
What are principal typings and what are they good for?

We demonstrate the pragmatic value of the principal typing property, a property distinct from ML's principal type property, by studying a type system with principal typings. The type system is based on rank 2 intersection types and is closely related to ML. Its principal typing property provides elegant support for separate compilation, including "smartest recompilation" and incremental type inference. Moreover, it motivates a new rule for typing recursive definitions that can type some interesting examples of polymorphic recursion.
Polymorphonuclear leucocyte migration through human dermal fibroblast monolayers is dependent on both beta 2-integrin (CD11/CD18) and beta 1-integrin (CD29) mechanisms.

Accumulation of leucocytes in inflammation involves their migration through vascular endothelium and then in the connective tissue. We investigated human polymorphonuclear leucocyte (PMNL) migration through a biological barrier of human dermal fibroblasts grown on microporous filters, as a model of PMNL migration in the connective tissue. PMNL did not migrate through a fibroblast monolayer unless a chemotactic factor, e.g. C5a, interleukin-8 (IL-8) or zymosan-activated plasma (ZAP; C5adesArg), was added. This migration was partially inhibited (35-70%, depending on the stimulus) by treatment of PMNL with monoclonal antibody (mAb) to CD18 (beta 2-integrins). Most of the CD18-independent migration was inhibited by mAb to beta 1-integrins (CD29). Inhibition by mAb to beta 1 was observed when the PMNL, but not the fibroblasts, were treated with mAb. The role of beta 1-integrins in PMNL transfibroblast migration was detectable only when the function of the CD11-CD18 complex was blocked, because mAb to beta 1-integrin alone had no significant effect on PMNL migration. Migration induced by C5a was more CD18-independent compared to IL-8 or C5adesArg. The CD18-independent migration was also inhibited by mAb to the beta 1-integrin subunits alpha 5 (of very late antigens-5; VLA-5) and alpha 6 (of VLA-6). Treatment of the fibroblasts (4 hr) with tumour necrosis factor-alpha (TNF-alpha) or IL-1 alpha enhanced C5a-induced PMNL transfibroblast migration and increased the proportion of migration utilizing the CD11-CD18 mechanism. However, TNF-alpha treatment had no effect on the degree of beta 1-integrin-dependent migration. These findings suggest that in response to the chemotactic factors C5a, IL-8 and C5adesArg, PMNL migration in the connective tissue is mediated by both CD11-CD18 (beta 2) and beta 1-integrins on the PMNL. The VLA-5 and VLA-6 members of beta 1-integrins are involved in this process. This is in contrast to PMNL migration across endothelium in this system, which is virtually all CD18 dependent with no significant role for beta 1-integrins.
Foaming of polypropylene with supercritical carbon dioxide: An experimental and theoretical study on a new process

A new process was used to foam polypropylene (PP) with batch foaming technique with supercritical carbon dioxide (scCO2) as the blowing agent. Comparing with the conventional process, the new one takes less time to foam and the foaming temperature range is much broader, which is about 2.5 h and 55°C, respectively. An activation model was established on the basis of mass equilibrium, this model was combined with classical nucleation theory and S-L EOS model to explain foaming behaviors of PP and simulate the cell nucleation and cell diameter. A satisfactory agreement between calculated and experimental values was obtained. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 2877–2885, 2013
Sulfur Dioxide Inhibits Extracellular Signal-regulated Kinase Signaling to Attenuate Vascular Smooth Muscle Cell Proliferation in Angiotensin II-induced Hypertensive Mice

Background:Clarifying the mechanisms underlying vascular smooth muscle cell (VSMC) proliferation is important for the prevention and treatment of vascular remodeling and the reverse of hyperplastic lesions. Previous research has shown that the gaseous signaling molecule sulfur dioxide (SO2) inhibits VSMC proliferation, but the mechanism for the inhibition of the angiotensin II (AngII)-induced VSMC proliferation by SO2 has not been fully elucidated. This study was designed to investigate if SO2 inhibited VSMC proliferation in mice with hypertension induced by AngII. Methods:Thirty-six male C57 mice were randomly divided into control, AngII, and AngII + SO2 groups. Mice in AngII group and AngII + SO2 group received a capsule-type AngII pump implanted under the skin of the back at a slow-release dose of 1000 ng·kg−1·min−1. In addition, mice in AngII + SO2 received intraperitoneal injections of SO2 donor. Arterial blood pressure of tail artery was determined. The thickness of the aorta was measured by elastic fiber staining, and proliferating cell nuclear antigen (PCNA) and phosphorylated-extracellular signal-regulated kinase (P-ERK) were detected in aortic tissues. The concentration of SO2 in serum and aortic tissue homogenate supernatant was measured using high-performance liquid chromatography with fluorescence determination. In the in vitro study, VSMC of A7R5 cell lines was divided into six groups: control, AngII, AngII + SO2, PD98059 (an inhibitor of ERK phosphorylation), AngII + PD98059, and AngII + SO2 + PD98059. Expression of PCNA, ERK, and P-ERK was determined by Western blotting. Results:In animal experiment, compared with the control group, AngII markedly increased blood pressure (P < 0.01) and thickened the aortic wall in mice (P < 0.05) with an increase in the expression of PCNA (P < 0.05). SO2, however, reduced the systemic hypertension and the wall thickness induced by AngII (P < 0.05). It inhibited the increased expression of PCNA and P-ERK induced by AngII (P < 0.05). In cell experiment, PD98059, an ERK phosphorylation inhibitor, blocked the inhibitory effect of SO2 on VSMC proliferation (P < 0.05). Conclusions:ERK signaling is involved in the mechanisms by which SO2 inhibits VSMC proliferation in AngII-induced hypertensive mice via ERK signaling.
Current research on surface finishing and coatings for aerospace bodies and structures – a review

Abstract This review reports recent developments of new coatings and surface treatments for aerospace bodies and structures. Advances in the field have been driven by the need for materials with improved performance characteristics and also by environmental legislative pressures. The traditional areas of corrosion and wear resistance are still receiving the greatest focus, although interest in other properties and the increasing use of composites continue to emerge.
Genetic Variation in the Nucleotide Excision Repair Pathway and Colorectal Cancer Risk

Nucleotide excision repair (NER) enzymes are critical for the removal of bulky DNA adducts caused by environmental carcinogens, such as heterocyclic amines and polycyclic aromatic hydrocarbons, which are found in two putative risk factors for colorectal cancer, tobacco smoke and meat cooked at high temperature. To examine the association between common genetic variants in NER genes and the risk of colorectal cancer, we conducted a case-cohort study within the CLUE II cohort. Twenty-two single nucleotide polymorphisms in 11 NER genes were genotyped in 250 colorectal cancer cases and a subcohort of 2,224 participants. Incidence rate ratios (RR) and 95% confidence intervals (95% CI) were estimated using a modified Cox regression model and robust variance estimate. The ERCC6 1213G variant, which is thought to reduce NER capacity, was associated with an increased risk of colorectal cancer compared with the homozygous wild type (RR, 1.36; 95% CI, 1.00-1.86 and RR, 2.64; 95% CI, 1.53-4.58 for the RG and GG genotypes respectively with Ptrend = 0.0006). Having at least one XPC 492H allele was also associated with an increased risk of colorectal cancer (RR, 1.75; 95% CI, 1.20-2.57). When the combined effects of ERCC6 R1213G and XPC R492H were examined, the risk of colorectal cancer significantly increased with increasing number of variant alleles (Ptrend = 0.00003). Our study suggests that genetic polymorphisms in the NER genes, ERCC6 and XPC, may be associated with an increased risk of colorectal cancer. (Cancer Epidemiol Biomarkers Prev 2006;15(11):2263–9)
Preservation of specific RNA distribution within the chromatin-depleted nuclear substructure demonstrated by in situ hybridization coupled with biochemical fractionation

Biochemical fractionation procedures previously shown to remove 95% of cellular protein, DNA, and phospholipid, were combined with fluorescence in situ hybridization to provide a critical evaluation of the retention and spatial preservation of specific primary transcripts within the chromatin-depleted nuclear substructure, operationally defined as the nuclear "matrix. " This unique approach made it possible to directly address whether nuclear extraction procedures preserve, create, or destroy ribonucleoprotein filament structures. Comparison of nuclei before and after fractionation demonstrated that localized foci or "tracks" of specific nRNA are unambiguously retained in the nuclear matrix preparation. Two well-characterized nuclear fractionation procedures were used and three Epstein-Barr virus-infected cell types investigated, including latently and permissively infected cells carrying integrated or episomal genomes. The EBV primary transcripts as well as nucleolar RNA were preserved within the remaining nuclear substructure with unambiguous spatial and quantitative fidelity. Image processing and quantitative microfluorimetry, together with [3H]thymidine labeling of DNA, show that essentially 100% of the RNA signal intensity remained after removal of 85% of the DNA. That the native RNA distribution was unchanged was shown in other experiments in which the same individual nRNA tracks were examined before and after fractionation. Results conclusively demonstrate that the tight restriction of RNA to highly localized sites is independent of bulk DNA removal and of extensive extraction of proteins and phospholipids. Hence, this work provides direct visual evidence that the primary transcripts studied are localized via their binding to, or comprising part of, non-chromatin nuclear substructure.
Boys' and young men's perspectives on violence in Northern Tanzania

The challenge of violence for youth in low-income countries includes a range of experiences from witnessing, to experiencing, to participating in violence. Although boys and young men are often the perpetrators of such violence, they may also be its victims. Yet little evidence exists from the voiced experiences of boys themselves on perceptions and interpretations of the violence around them. Given the numerous negative health implications of violence for boys, for the girls and other boys with whom they interact, and for the health of their future partners and families, we conducted an in-depth study in rural and urban Tanzania with adolescent boys on the masculinity norms shaping their transitions through puberty that might be contributing to high-risk behaviours, including engagement in violence. The findings identified underlying societal gendered norms influencing the enactment of violence, and recommendations from the boys on how to diminish the violence around them. Additional research is needed with boys on the social norms and structural factors influencing their engagement in violence.
Exponential stability of stochastic neural networks with time-variant mixed time-delays and uncertainty

In this paper, the global exponential stability analysis is considered for time-variant stochastic neural networks with mixed time-variant time-delays and parameter uncertainties. The delays are time-variant, and the uncertainties are norm-bounded for all of the network parameters. The purpose of this paper is to establish easily and verifiable conditions which the delays neural network is globally, robustly, exponentially stable in the mean square for all admissible parameter uncertainties. By resorting to the Lyapunov-Krasovskii stability theory and the stochastic analysis method, a linear matrix inequality (LMI) approach is developed to derive the stability required. An example is provided to demonstrate the effectiveness and applicability of the proposed criteria.
Using Problem Frames and projections to analyze requirements for distributed systems

Subproblems in a problem frames decomposition frequently make use of projections of the complete problem context. One specific use of projec-tions occurs when an eventual implementation will be distributed, in which case a subproblem must interact with (use) the machine in a projection that represents another subproblem. We refer to subproblems used in this way as services, and propose an extension to projections to represent services as a spe-cial connection domain between subproblems. The extension provides signifi-cant benefits: verification of the symmetry of the interfaces, exposure of the machine-to-machine interactions, and prevention of accidental introduction of shared state. The extension’s usefulness is validated using a case study.
Integrating SELinux with Security-typed Languages

Traditionally, operating systems have enforced MAC and information flow policies with minimal dependence on application programs. However, there are many cases where systems depend on user-level programs to enforce information flows. Previous approaches to handling this problem, such as privilege-separation of application components or assuming trust in application information flow enforcement, are prone to error and cumbersome to manage. On the other hand, recent advances in the area of security-typed languages have enabled the development of realistic applications with formally and automatically verified information flow controls. In this paper, we examine what it takes to integrate information flow enforcement of applications written in a security-typed extension of Java (called Jif) with SELinux. To this end, we have extended the Jif infrastructure to support interaction with SELinux security contexts, and we describe the SELinux policy and system calls which are necessary for a successful integration. We have also identified the need for further services, such as a means of formally verifying compliance between information flow policies. We have demonstrated the utility, flexibility and security of our approach by constructing a prototype multi-level secure email client.
Seedling survival and growth of three ectomycorrhizal caesalpiniaceous tree species in a Central African rain forest

Tree recruitment is determined in part by the survivorship and growth of seedlings. Two seedling cohorts of the three most abundant caesalpiniaceous species forming groves at Korup, Cameroon, were followed from 1995/1997 to 2002, to investigate why Microberlinia bisulcata, the most abundant species, currently has very few recruits compared with Tetraberlinia korupensis and T. bifoliolata. Numbers of seedlings dying, and the heights and leaf numbers of survivors, were recorded on 30 occasions. Survivorship after 2.5 y was 30% for M. bisulcata and 59% for the similar Tetraberlinia spp. together. After 7 y the corresponding values were 4 and 21%. Growth of all species was slow for the first 4 y; but survivors of T. korupensis became 63% taller, as the other species stagnated, by 7 y. The poor recruitment of M. bisulcata was the result of its very low seedling survival. Within species, the tallest seedlings of M. bisulcata and T. bifoliolata, but medium-height ones of T. korupensis, survived longest. This was likely due to higher root allocation in T. korupensis. Seedling dynamics of M. bisulcata and T. korupensis over 7 y accorded well with relative abundances of adult trees; T. bifoliolata is predicted to recruit later.
Oasis or Mirage ?

This paper will review the design of statistical studies, and comment on the difficulty of drawing causal inferences from non-experimental data. The most basic design is a comparison of rates for two groups of subjects. Subjects in one group get the treatment of interest; subjects in the other group are the controls. The difficulty is ensuring that the groups are similar, apart from the treatment. Experiments versus observational studies In a randomized controlled experiment, the investigators assign the subjects to treatment or control, for instance, by tossing a coin. In an observational study, the subjects assign themselves. The difference is crucial, because of confounding. Confounding means a difference between the treatment group and the control group, other than the causal factor of primary interest. The con-founder may be responsible for some or all of the observed effect that is of interest. In a randomized controlled experiment, near enough, chance will balance the two groups. Thus, confounding is rarely a problem. In an observational study, however, there often are important differences between the treatment and control groups. That is why experiments provide a more secure basis for causal inference than observational studies. When there is a conflict, experiments usually trump observational studies. However, experiments are hard to do, and well-designed observational studies can be informative. In social science and medicine, a lot of what we know— or think we know—comes from observational studies. Most studies on smoking are observational. Taken together, they make a powerful case that smoking kills. A great many lives have been saved by tobacco control measures which were prompted by the observational studies. There are a few experiments; the treatments (like counseling) were aimed at getting smokers to quit. Paradoxically, results from the experiments are inconclusive. Even with studies on smoking, confounding can be a problem. Smokers die at higher rates from cirrhosis than non-smokers. Cigarettes cause heart disease and cancer, but they do not cause cirrhosis. What explains the association? The confounder is drinking. Smokers drink more, and alcohol causes cirrhosis. Here, confounding can be handled by sorting people into groups by the amount they drink and the amount they smoke. At each level of drinking, there will be little association between smoking and the death rate from cirrhosis. By contrast, at each level of smoking, there will be a strong association between drinking and cirrhosis. This sort of analysis can be done by cross-tabulation. The …
Does Fuel Hedging Make Economic Sense? The Case of the Us Airline Industry

This paper investigates the fuel hedging behavior of firms in the US airline industry during 1994-2000 to examine whether such hedging is a source of value for these companies. The investment climate in the airline industry conforms well to the theoretic framework of Froot, Scharfstein, and Stein (1993). Specifically, airline industry investment opportunities correlate positively with jet fuel costs, while higher fuel costs are consistent with lower cash flow. Given that jet fuel costs are hedgeable, airlines with a desire for expansion may find value in hedging future purchases of jet fuel. The results show that jet fuel hedging is positively related to airline firm value. The coefficients on hedging indicator variables in regression analysis suggest that the hedging premium constitutes approximately a 12-16% increase in firm value. We find that the positive relation between hedging and value increases in capital investment. This result is consistent with the assertion that the principal benefit of jet fuel hedging by airlines comes from reduction of underinvestment costs.