Miracle-dz/UniFAR-FTUs huggingface dataset:
Breastfeeding Is Associated with Decreased Hospitalization for Neonatal Fever.

BACKGROUND Breastfeeding is the recommended method for feeding newborns and infants. It confers significant health benefits upon both infant and mother and provides developmental, social, and economic advantages. OBJECTIVE This study explored possible correlations between breastfeeding and neonatal fever (NF). MATERIALS AND METHODS One hundred and forty infants hospitalized for fever during the first month of life (NF) were identified by retrospective chart review. These were matched with healthy infants born on the same day in the study hospital and who were not hospitalized in the first month of life. A structured telephone interview to determine breastfeeding practice was conducted with the parents of all study participants. RESULTS The prevalence of children who were formula fed or only partially breastfed was significantly higher among hospitalized children compared to healthy controls (66% versus 34%, respectively, p < 0.001). This association remained after adjusting for exposure to smoke, gender, and household crowding. Exposure to household smoke was also independently associated with hospitalization for NF. CONCLUSION Increased rates of breastfeeding should result in fewer hospitalizations for NF, fewer laboratory investigations, less intravenous antibiotic therapy and its complications, and lower indirect expenses. This study demonstrates that exclusive or predominant breastfeeding, as opposed to formula or partial breastfeeding, of infants less than 1 month of age reduces the risk of NF-related hospitalization by over two-fold. Our data provide new evidence of the health benefits of breastfeeding. The retrospective nature of the study and possible recall bias are limitations of the study.
A new generation of drug-eluting stents: Indications and outcomes of bioresorbable vascular scaffolds

Drug-eluting stents (DES) are increasingly being used as a less invasive alternative to coronary artery bypass grafting. Early generation DES had durable polymers that provided acceptable efficacy outcomes but had high rates of stent thrombosis leading to myocardial infarction and death. Second-generation DES have improved outcomes by reducing stent thrombosis and recurrent stenosis. Newer DES with biodegradable polymers have similar efficacy as second-generation DES, but have higher rates of stent thrombosis. This review compares outcomes of bioresorbable scaffolds and looks at stent technology developments that may improve outcomes.
Real-time monitoring of hepatocyte differentiation and impedimetric activity using impedance sensing

Stem cell derived hepatocytes are desirable to develop renewable in vitro liver models that could accelerate drug discovery. To achieve success, these models require further optimization. To improve the process, we employed real time and label-free monitoring of the differentiation process using impedance sensing. Finally, we developed and introduced novel algorithms to better interrogate impedimetric cell activity.
The Effects of Aging on the Regulation of T-Tubular ICa by Caveolin in Mouse Ventricular Myocytes

Abstract Aging is associated with diminished cardiac function in males. Cardiac excitation-contraction coupling in ventricular myocytes involves Ca influx via the Ca current (ICa) and Ca release from the sarcoplasmic reticulum, which occur predominantly at t-tubules. Caveolin-3 regulates t-tubular ICa, partly through protein kinase A (PKA), and both ICa and caveolin-3 decrease with age. We therefore investigated ICa and t-tubule structure and function in cardiomyocytes from male wild-type (WT) and caveolin-3-overexpressing (Cav-3OE) mice at 3 and 24 months of age. In WT cardiomyocytes, t-tubular ICa-density was reduced by ~50% with age while surface ICa density was unchanged. Although regulation by PKA was unaffected by age, inhibition of caveolin-3-binding reduced t-tubular ICa at 3 months, but not at 24 months. While Cav-3OE increased cardiac caveolin-3 protein expression ~2.5-fold at both ages, the age-dependent reduction in caveolin-3 (WT ~35%) was preserved in transgenic mice. Overexpression of caveolin-3 reduced t-tubular ICa density at 3 months but prevented further ICa loss with age. Measurement of Ca release at the t-tubules revealed that the triggering of local Ca release by t-tubular ICa was unaffected by age. In conclusion, the data suggest that the reduction in ICa density with age is associated with the loss of a caveolin-3-dependent mechanism that augments t-tubular ICa density.
Iron Sulfur and Molybdenum Cofactor Enzymes Regulate the Drosophila Life Cycle by Controlling Cell Metabolism

Iron sulfur (Fe-S) clusters and the molybdenum cofactor (Moco) are present at enzyme sites, where the active metal facilitates electron transfer. Such enzyme systems are soluble in the mitochondrial matrix, cytosol and nucleus, or embedded in the inner mitochondrial membrane, but virtually absent from the cell secretory pathway. They are of ancient evolutionary origin supporting respiration, DNA replication, transcription, translation, the biosynthesis of steroids, heme, catabolism of purines, hydroxylation of xenobiotics, and cellular sulfur metabolism. Here, Fe-S cluster and Moco biosynthesis in Drosophila melanogaster is reviewed and the multiple biochemical and physiological functions of known Fe-S and Moco enzymes are described. We show that RNA interference of Mocs3 disrupts Moco biosynthesis and the circadian clock. Fe-S-dependent mitochondrial respiration is discussed in the context of germ line and somatic development, stem cell differentiation and aging. The subcellular compartmentalization of the Fe-S and Moco assembly machinery components and their connections to iron sensing mechanisms and intermediary metabolism are emphasized. A biochemically active Fe-S core complex of heterologously expressed fly Nfs1, Isd11, IscU, and human frataxin is presented. Based on the recent demonstration that copper displaces the Fe-S cluster of yeast and human ferredoxin, an explanation for why high dietary copper leads to cytoplasmic iron deficiency in flies is proposed. Another proposal that exosomes contribute to the transport of xanthine dehydrogenase from peripheral tissues to the eye pigment cells is put forward, where the Vps16a subunit of the HOPS complex may have a specialized role in concentrating this enzyme within pigment granules. Finally, we formulate a hypothesis that (i) mitochondrial superoxide mobilizes iron from the Fe-S clusters in aconitase and succinate dehydrogenase; (ii) increased iron transiently displaces manganese on superoxide dismutase, which may function as a mitochondrial iron sensor since it is inactivated by iron; (iii) with the Krebs cycle thus disrupted, citrate is exported to the cytosol for fatty acid synthesis, while succinyl-CoA and the iron are used for heme biosynthesis; (iv) as iron is used for heme biosynthesis its concentration in the matrix drops allowing for manganese to reactivate superoxide dismutase and Fe-S cluster biosynthesis to reestablish the Krebs cycle.
Blunted cardiovascular responses to daytime activities as related to reduced nocturnal blood pressure decline

Background: Individuals showing less than a 10% decline in blood pressure at night (“nondippers ”) are known to be at increased risk for hypertension and other cardiovascular conditions.Purpose: This research tested the assertion by Räikkönen et al. (1) that nondippers show blunted cardiovascular responses to activities during daytime hours.Methods: Ambulatory blood pressure and impedance monitoring was performed with 149 young adults in Singapore. At each daytime blood pressure reading, participants completed a computerized questionnaire indicating location, posture, physical activities, feelings, and social interactions.Results: Significant interactions between dipper status and feeling tired, location, posture, and physical activity provided qualified support for the blunting hypothesis. However, blunting of BP responses was not attributable to blunting of either cardiac output or total peripheral resistance responses.Conclusion: Nondippers appear to show blunted daytime responses to certain types of daytime activities. However, these effects are limited and appear to be the result of different mechanisms than those responsible for reduced nighttime blood pressure decline.
Improving Statistical Word Alignment with a Rule-Based Machine Translation System

The main problems of statistical word alignment lie in the facts that source words can only be aligned to one target word, and that the inappropriate target word is selected because of data sparseness problem. This paper proposes an approach to improve statistical word alignment with a rule-based translation system. This approach first uses IBM statistical translation model to perform alignment in both directions (source to target and target to source), and then uses the translation information in the rule-based machine translation system to improve the statistical word alignment. The improved alignments allow the word(s) in the source language to be aligned to one or more words in the target language. Experimental results show a significant improvement in precision and recall of word alignment.
Camera‐augmented mobile C‐arm (CamC): A feasibility study of augmented reality imaging in the operating room

In orthopaedic trauma surgery, image‐guided procedures are mostly based on fluoroscopy. The reduction of radiation exposure is an important goal. The purpose of this work was to investigate the impact of a camera‐augmented mobile C‐arm (CamC) on radiation exposure and the surgical workflow during a first clinical trial.
Genetic Loci Controlling Carotenoid Biosynthesis in Diverse Tropical Maize Lines

The discovery and use of genetic markers associated with carotenoid levels can help to exploit the genetic potential of maize for provitamin A accumulation more effectively. Provitamin A carotenoids are classes of carotenoids that are precursors of vitamin A, an essential micronutrient in humans. Vitamin A deficiency is a global public health problem affecting millions of people, especially in developing countries. Maize is one of the most important staple crops targeted for provitamin A biofortification to help alleviate vitamin A deficiency in developing countries. A genome-wide association study (GWAS) of maize endosperm carotenoids was conducted using a panel of 130 diverse yellow maize tropical inbred lines genotyped with Genotyping by Sequencing (GBS) SNP markers. Numerous significant association signals co-localizing with the known carotenoid biosynthesis genes crtRB1, lcyE and ZEP1 were identified. The GWAS confirmed previously reported large effects of the two major carotenoid biosynthesis genes lcyE and crtRB1. In addition, significant novel associations were detected for several transcription factors (e.g., RING zinc finger domain and HLH DNA-binding domain super family proteins) that may be involved in regulation of carotenoid biosynthesis in maize. When the GWAS was re-conducted by including the major effects of lcyE and crtRB1 genes as covariates, a SNP in a gene coding for an auxin response factor 20 transcription factor was identified which displayed an association with β-carotene and provitamin A levels. Our study provides a foundation for design and implementation of genomics-assisted selection strategies for provitamin A maize breeding in tropical regions, and advances efforts toward identification of additional genes (and allelic variants) involved in the regulation of carotenoid biosynthesis in plants.
Autophagy: A brief overview in perspective of dermatology

Autophagy, literally meaning “self-eating,” is an intracellular catabolic process of delivering cytosol and/or its specific content to the lysosomes for degradation.The resulting macromolecular constituents are recycled and utilized again by the cells. Basal level autophagy plays an important role in cellular homeostasis through the elimination of the old or damaged organelles, as well as aggregated intracellular proteins. Autophagy refers to sequestration of intact organelles along with a portion of cytosol, into a double-or multi-membrane structure known as phagophore, which elongates, and after closure, forms a vesicular structure known as the autophagosome. Subsequently, the mature autophagosome fuses with a lysosome, thereby forming a single membrane structure, an autolysosome. Autophagy plays a critical role in inflammation, autoimmunity and cellular differentiation. Skin serves as the first line of defense against a variety of environmental insults and autophagy is thought to be a form of an endogenous defense mechanism against such environmental derangements. Autophagy has been linked with keratinocyte differentiation and melanocyte survival, as well as with the pathogenesis of diverse skin disorders including systemic lupus erythematosus, systemic sclerosis, psoriasis, vitiligo, infectious skin diseases and cancer. Autophagy has been one of the most studied phenomena in cell biology and pathophysiology, and given its broad clinical implications, has become a major target for drug discovery. The last decade has seen a substantial upsurge in autophagy-related research and publications; still, the dermatology literature appears to be less initiated. Autophagy will probably change our understanding of dermatological disorders/medicines. Hence, a basic knowledge of autophagy is a prerequisite to understand the developments in the field of autophagy-related research.
Study on the Slicing of Sapphire Using a Wire Tool

This work examined improvements in cutting efficiency obtained during the slicing of sapphire workpieces when adding CeO2 to the cutting fluid. Various machining parameters, including the cutting temperature, machining surface tolerance, surface quality and tool wear, were assessed. It was confirmed that both the cutting temperature and the machining surface tolerance are reduced by the presence of CeO2 in the cutting fluid. Observations of the machined surfaces and the cutting tool also demonstrated that both brittle fracturing of the surface and loss of abrasive grains were suppressed following the addition of CeO2. These results suggest that the cutting temperature likely affects the accuracy of the cutting process and that CeO2 appears to improve cutting efficiency by reducing the workpiece temperature and by stabilizing the cutting process.
Multiplex PCR Pathogen Detection in Two Severely Burned Patients With Suspected Septicemia

The case studies reported in this article strive to illustrate the clinical value of multiplex polymerase chain reaction (PCR)-based pathogen detection in patients with burn sepsis. Adult (age ≥18 years) burn patients (≥20% TBSA) presenting with signs and symptoms of burn sepsis were enrolled into a prospective, observational trial. Patients received PCR testing in parallel to routine blood cultures. The authors report two cases in which PCR was used to rapidly detect pathogens in whole blood from burn patients with suspected septicemia. PCR identified Escherichia coli in 5.8 hours in case 1. Blood and sputum cultures required 17 hours for Gram stain results. Empiric ceftriaxone therapy was initiated. Blood cultures required an additional 18 hours to identify the same pathogen detected by PCR. Ceftriaxone was replaced with ciprofloxacin for improved coverage. Follow-up antimicrobial susceptibility results revealed intermediate ciprofloxacin resistance. Meropenam therapy was initiated. In case 2, PCR detected Pseudomonas aeruginosa in 5.45 hours while blood cultures remained negative. Respiratory cultures became positive for P. aeruginosa 2 days later. Serial PCR samples continued detecting P. aeruginosa despite negative blood cultures and appropriate antimicrobial therapy. The patient later became hypotensive and coagulopathic and expired. For both patient cases, PCR identified high-risk pathogens faster than culture methods. In the second patient case, PCR identified the presence of pathogen DNA despite negative cultures before the onset of septic shock and presumptive disseminated intravascular coagulation. These results warrant further investigation to determine the clinical significance of pathogen DNA in burn sepsis.
Relationship between physical performance and quality of life in Charcot‐Marie‐Tooth disease: a pilot study

Charcot‐Marie‐Tooth (CMT) is a rare inherited peripheral neuropathy in which quality of life (QoL) is reduced compared with the general population. This paper investigates the relationship between QoL and physical performance in people with CMT with the aim of identifying avenues for future research into rehabilitation strategies. Cross‐sectional data was obtained from 10 participants (5 men, 5 women, age 46 ± 13 years, height 1.7 ± 0.1 m, body mass 77 ± 17 kg) with CMT (CMT1A n = 5; CMT‐X n = 3; unknown genetic origin n = 2). Participants were evaluated for QoL, falls efficacy (FES), balance, mobility, muscle strength, and power. Physical component score (PCS) of the Short Form‐36 (SF‐36) was significantly and directly related to higher leg press power (r = 0.75, p = 0.02). Better FES scores were significantly related to faster habitual gait speed (r = −0.70, p = 0.02), left hip abduction, and seated row strength (r = −0.68, p = 0.03; r = −0.73, p = 0.03, respectively). Future research should aim to substantiate these preliminary findings in a larger cohort and investigate whether interventions targeting muscle strength and power can improve QoL and mobility outcomes in people with CMT.
Investigation on the strength distribution of unidirectional ceramic matrix mini-composites with porous matrix phase

Abstract In the present work, mechanical tests on unidirectional oxi de/oxide ceramic matrix mini-composites with porous matrix phase were carried out. The mini-composi tes were manufactured by slurry infiltration and glued on mounting tabs in order to facilitat e handling, alignment and clamping during mechanical testing. The specimens were thorough ly investigated by microscopy to determine their microstructural characteristics and pote ntial surface defects.
Optimising the overall power usage on the SpiNNaker neuromimetic platform

Simulations of biological tissue have been extensively used to replicate phenomena observed by in-vivo and in-vitro experiments as an alternative methodology for explaining how computations could take place in a brain region. Additional benefits of simulated neural networks over in-vivo experiments include greater observability, experimental control and reproducibility. General-purpose supercomputers provide the computational power and parallelism required to implement highly complex neural models, but this comes at the expense of high power requirements and communication overheads. Moreover, there are certain cases where real-time simulation performance is a desirable feature, for example in the field of cognitive robotics where embodied agents need to interact with their environment through biologically inspired asynchronous sensors. The SpiNNaker neuromimetic platform is a scalable architecture that has been designed to enable energy-efficient, large-scale simulations of spiking neurons in biological realtime. This work is based on a recent study which revealed that while they are generally energy efficient, SpiNNaker chips dissipate significant amount of power whilst in the idle state. In this paper we perform a systematic investigation into the overall energy consumption of a SpiNNaker system and propose a number of optimised suspend modes in order to reduce this. The proposed implementation is 60% more energy efficient in the idle state, 50% in the uploading and 52% in the downloading phases, while the power dissipation of the whole simulation is reduced by 52%. For demonstration purposes, we run a neural network simulation comprising thousands of neurons and millions of complex synapses on a 48-chip SpiNNaker board, generating millions of synaptic events per second.
THE BI-SUBSTITUTED HYDROXYAPATITE AS RADIO-OPAQUE MATERIAL

This study relates to a new apatite material which is biocompatible and exhibits radio-opacity, enhancing its utility in the dental and medical fields. The bismuth-substituted hydroxyapatite was obtained by means of wet chemical method, that is, by co-precipitation reactions. The effects of the bismuth substitution for calcium on the morphology and optical proprieties of the resulting powder were investigated by scanning electron microscopy (SEM) coupled with X-ray analysis (EDX), X-ray powder diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). Bi-substituted hydroxyapatite is radio-opaque, and it can be detected by X-rays and computed tomography.
Eosinophilic Bronchitis without Asthma

Background: Eosinophilic bronchitis without asthma causes chronic coughs without the physiologic features of asthma. The aim of this study was to review the clinical features, pathogenesis, diagnosis, treatment and prognosis of this condition. Methods: The current literature was reviewed using Pubmed for all studies published in the English language using the search term ‘eosinophilic bronchitis’. Results: Eosinophilic bronchitis presents as normal spirometry, without evidence of airway hyperresponsiveness, and normal peak expiratory flow variability. When compared with asthma, mast cell recruitment to the superficial airways and mast cell activation appear to be a feature of eosinophilic bronchitis. In contrast, mast cell infiltration in the smooth muscle is significantly higher in asthma patients than in either eosinophilic bronchitis patients or healthy control subjects. In this condition, the absence of high IL-13 expression can contribute to the normal airway reactivity. The cough usually responds well to inhaled corticosteroids but dose and duration of treatment remain unclear. The condition can be transient, episodic or persistent unless treated, and occasionally, patients may require long-term treatment with oral corticosteroids. Conclusions: The condition is an important cause of chronic coughs which are corticosteroid responsive. The study of eosinophilic bronchitis suggests that eosinophil-dependent mechanisms are generally not important in the pathogenesis of asthma.