Miracle-dz/UniFAR-FTUs huggingface dataset:
LES of the LS89 cascade: influence of inflow turbulence on the flow predictions

Free-stream turbulence preceding high-pressure turbine blades has a crucial impact on blade fields including the heat transfer on the wall. Many parameters characterize this turbulence; its intensity, length scales and physical spectrum are addressed in the study of various operating points of the LS89 configuration. Usually, operating points where weak turbulence is injected are well predicted for all fields by Direct Numerical Simulations (DNS) and Large Eddy Simulations (LES). The MUR235 operating point however, with an experimentally injected turbulence level of 6%, remains incorrectly predicted when im-posing the experimental values in the simulations. Such difficulties raise many questions amongst which mesh size and turbulent kinetic energy spectrum are of specific importance for LES. Going away from synthetic turbulence injection by imposing a physical energy spectrum can help improving the prediction of heat transfer. From the present study, it seems that turbulent spots developing in a pre-transition region for higher levels of tur-bulence on the suction side are important features to capture for proper predictions. In parallel, typical structures of boundary layers such as streamwise oriented vortices have been observed and their existence conditions the heat transfer field on the blade wall. From this specific study, all of these physical processes are seen to be highly dependent on the turbulent specification and turbulent transition observed for the MUR235 case. De-pending on these inflow specifications, a transitional boundary layer may be encountered upstream of the shock thus modifying the heat transfer profile.
Effects of Lewis number on the statistics of the invariants of the velocity gradient tensor and local flow topologies in turbulent premixed flames

The behaviours of the three invariants of the velocity gradient tensor and the resultant local flow topologies in turbulent premixed flames have been analysed using three-dimensional direct numerical simulation data for different values of the characteristic Lewis number ranging from 0.34 to 1.2. The results have been analysed to reveal the statistical behaviours of the invariants and the flow topologies conditional upon the reaction progress variable. The behaviours of the invariants have been explained in terms of the relative strengths of the thermal and mass diffusions, embodied by the influence of the Lewis number on turbulent premixed combustion. Similarly, the behaviours of the flow topologies have been explained in terms not only of the Lewis number but also of the likelihood of the occurrence of individual flow topologies in the different flame regions. Furthermore, the sensitivity of the joint probability density function of the second and third invariants and the joint probability density functions of the mean and Gaussian curvatures to the variation in Lewis number have similarly been examined. Finally, the dependences of the scalar--turbulence interaction term on augmented heat release and of the vortex-stretching term on flame-induced turbulence have been explained in terms of the Lewis number, flow topology and reaction progress variable.
Train the brain! Immediate sensorimotor effects of mentally-performed flexor exercises in patients with neck pain. A pilot study.

BACKGROUND Sensorimotor tests, like cranio-cervical flexion and cervical joint position sense tests, share a strong cognitive component during their execution. However, cognitive training for those tests has not been investigated so far. AIM The aim of this study was to compare mental and physical exercises for improving the sensorimotor function of the cervical spine. DESIGN A within-subject design with 16 participants. SETTING Outpatient physiotherapy center. POPULATION Patients with chronic neck pain. METHODS Participants were instructed to perform specific active or mental exercises for the deep and superficial neck flexor muscles. The primary outcomes were cranio-cervical flexion test performance, postural sway, cervical joint position sense and pressure pain threshold. A mixed model analysis was used. RESULTS The interventions improved cranio-cervical flexion performance (P<0.001), with no difference between actively or mentally-performed exercises. Postural sway increased after actively (P<0.01) and mentally (P<0.05) performed deep cervical neck flexor exercises, but not after superficial neck flexor exercises. Mentally-performed superficial neck flexor exercises improved cervical joint position sense when compared to mentally-performed deep cervical flexor exercises (P<0.05), and actively performed superficial neck flexor exercises were effective in improving cervical joint position sense acuity compared to mentally-performed deep cervical flexor exercises (P<0.05) for relocation tasks in the transverse plane. The pressure pain threshold at the cervical spine increased after active deep cervical flexor exercises (P<0.05) and after mental superficial neck flexor exercise (P<0.05). CONCLUSIONS Mentally-performed deep cervical flexor exercises improved cranio-cervical flexion test performance and pressure pain threshold at the cervical spine, while postural sway increased. Mentally-performed superficial neck flexor exercises improved cervical joint position sense acuity more than mentally-performed deep cervical flexor exercises. CLINICAL REHABILITATION IMPACT Mentally-performed exercises are recommended in the early stages of rehabilitation to counteract extensive muscle impairment, and these can be incorporated into daily routine.
An RFID Indoor Positioning Algorithm Based on Support Vector Regression

Nowadays, location-based services, which include services to identify the location of a person or an object, have many uses in social life. Though traditional GPS positioning can provide high quality positioning services in outdoor environments, due to the shielding of buildings and the interference of indoor environments, researchers and enterprises have paid more attention to how to perform high precision indoor positioning. There are many indoor positioning technologies, such as WiFi, Bluetooth, UWB and RFID. RFID positioning technology is favored by researchers because of its lower cost and higher accuracy. One of the methods that is applied to indoor positioning is the LANDMARC algorithm, which uses RFID tags and readers to implement an Indoor Positioning System (IPS). However, the accuracy of the LANDMARC positioning algorithm relies on the density of reference tags and the performance of RFID readers. In this paper, we introduce the weighted path length and support vector regression algorithm to improve the positioning precision of LANDMARC. The results show that the proposed algorithm is effective.
Individuality, Relatedness, Or None of the Above? How Thinking Concretely Can Impair the Activation of Self-Relevant Goals

This research shows the importance of mindsets as cognitive processes that can interact with people’s self-representations and impact their interpretations of consumer situations. In four experiments, we show that individuals are more likely to bring to mind goals linked to a primed self-concept when they are in an abstract mindset (compared to a concrete mindset). Participants in an abstract mindset who are primed with independence bring to mind more independence goals whereas those primed with interdependence bring to mind more relatedness goals. In contrast, participants in a concrete mindset focus on concrete experiences from the situation regardless of self-concept priming.
On Contrast Sensitivity in an Image Difference Model

The importance of the human contrast sensitivity function (CSF) in a color image difference metric is examined. The contrast sensitivity function is used to extend traditional color difference equations for use with complex image stimulus. Three CSF models of various complexities are evaluated using psychophysical image difference data. Additionally, two models of spatial frequency adaptation are evaluated. These models adjust the peak sensitivity and general shape of the contrast sensitivity functions to better correlate with complex stimuli.
Disruption management for commercial airlines: methods and results for the ROADEF 2009 Challenge

A disruption management problem for commercial airlines has been presented by Amadeus for the ROADEF 2009 Challenge, an international competition organised by the French Operational Research and Decision Support Society (ROADEF). This paper presents this industrial large scale optimisation problem and underlines its difficulties compared to previously tackled problems in the area. We review the most prominent methods proposed by the candidates and provide the official results and participant ranking. Last, as lessons learned from this experience, we draw guidelines for further research. [Received 11 November 2009; Revised 4 June 2010; Accepted 29 November 2010]
Nonparametric covariate-adjusted response-adaptive design based on a functional urn model

In this paper we propose a general class of covariate-adjusted response-adaptive (CARA) designs based on a new functional urn model. We prove strong consistency concerning the functional urn proportion and the proportion of subjects assigned to the treatment groups, in the whole study and for each covariate profile, allowing the distribution of the responses conditioned on covariates to be estimated nonparametrically. In addition, we establish joint central limit theorems for the above quantities and the sufficient statistics of features of interest, which allow to construct procedures to make inference on the conditional response distributions. These results are then applied to typical situations concerning Gaussian and binary responses.
The Comparative Effects of Genetically Modified Maize and Conventional Maize on Rats

1 Hasan Kiliçgün1, Cebrail Gürsul2, Mukadder Sunar3, Gülden Gökşen4 1Department of Nutrition and Dietetic, School of Health, 2Faculty of Medicine, Department of Physiology, 3Faculty of Medicine, Department of Anatomy, 4Department of Nutrition and Dietetic, School of Health, University of Erzincan, Erzincan, Turkey Genetiği Değiştirilmiş Mısır / Genetically Modified Maize The Comparative Effects of Genetically Modified Maize and Conventional Maize on Rats
Early estimates of epidemic final sizes

ABSTRACT Early in a disease outbreak, it is important to be able to estimate the final size of the epidemic in order to assess needs for treatment and to be able to compare the effects of different treatment approaches. However, it is common for epidemics, especially of diseases considered dangerous, to grow much more slowly than expected. We suggest that by assuming behavioural changes in the face of an epidemic and heterogeneity of mixing in the population it is possible to obtain reasonable early estimates.
Explorative analyses of protein biomarkers in patients with early rheumatoid arthritis achieving sustained drug-free remission after treatment with tocilizumab- or methotrexate-based strategies: from transcriptomics to proteomics.

OBJECTIVES Previously, we identified networks of co-expressed genes related to achieving sustained drug-free remission (sDFR). The aim of the present exploratory analysis was to identify inflammatory proteins associated with achieving sDFR and their enriched biological pathways, and compare these pathways with those found in the previous transcriptomic analyses. METHODS Serum samples were used from 60 patients who participated in the U-Act-Early trial and were treated-to-target with tocilizumab plus methotrexate, or tocilizumab or methotrexate; 37 achieved sDFR (≥3 months drug-free) and 23 did not (controls). Luminex® multi-analyte profiling (xMAP)® was used to measure 85 proteins. Partial least square discriminant analyses (PLSDA) identified proteins associated with achieving sDFR within each strategy arm, which were thereafter used for pathway analyses. RESULTS PLSDA identified 9, 14 and 13 relevant proteins in the tocilizumab plus methotrexate, tocilizumab and methotrexate arm, respectively and pathway analyses thereafter identified respectively 49, 88 and 117 significantly enriched gene ontology (GO) terms. When comparing these terms with those previously found in the transcriptomic analyses, corresponding pathways were related in the tocilizumab arm to activity of leukocytes; in the methotrexate arm to response of stimuli and regulation of the Janus kinase signal transducer and activator of transcription (JAK-STAT) pathway. In the tocilizumab plus methotrexate arm, no corresponding enriched pathways were found. CONCLUSIONS Multiple proteins were associated with achieving sDFR and several biological pathways corresponded, mainly in the methotrexate arm, with our previous transcriptomic findings potentially providing further insights into gene expression and protein translation in newly diagnosed RA patients.
Classification of Alzheimer's and MCI Patients from Semantically Parcelled PET Images: A Comparison between AV45 and FDG-PET

Early identification of dementia in the early or late stages of mild cognitive impairment (MCI) is crucial for a timely diagnosis and slowing down the progression of Alzheimer's disease (AD). Positron emission tomography (PET) is considered a highly powerful diagnostic biomarker, but few approaches investigated the efficacy of focusing on localized PET-active areas for classification purposes. In this work, we propose a pipeline using learned features from semantically labelled PET images to perform group classification. A deformable multimodal PET-MRI registration method is employed to fuse an annotated MNI template to each patient-specific PET scan, generating a fully labelled volume from which 10 common regions of interest used for AD diagnosis are extracted. The method was evaluated on 660 subjects from the ADNI database, yielding a classification accuracy of 91.2% for AD versus NC when using random forests combining features from cross-sectional and follow-up exams. A considerable improvement in the early versus late MCI classification accuracy was achieved using FDG-PET compared to the AV-45 compound, yielding a 72.5% rate. The pipeline demonstrates the potential of exploiting longitudinal multiregion PET features to improve cognitive assessment.
Visualizing Leukocyte Rolling and Adhesion in Angiotensin II-Infused Mice: Techniques and Pitfalls

Epifluorescence intravital video microscopy (IVM) of blood vessels is an established method to evaluate the activation of immune cells and their ability to role and adhere to the endothelial layer. Visualization of circulating cells by injection of fluorescent dyes or fluorophore-coupled antibodies is commonly used. Alternatively, fluorescent reporter mice can be used. Interactions of leukocytes, in particular lysozyme M+ (LysM+) monocytes, with the vessel wall play pivotal roles in promoting vascular dysfunction and arterial hypertension. We here present the technique to visualize and quantify leukocyte rolling and adhesion in carotid arteries in angiotensin II (AngII)-induced hypertension in mice by IVM. The implantation of a catheter damages the vascular wall and leads to altered blood cell responses. We compared different injection techniques and administration routes to visualize leukocytes in a LysMCre+IRG+ mouse with widespread expression of red fluorescent protein and conditional expression of green fluorescent protein in LysM+ cells. To study LysM+ cell activation, we used AngII infused mice in which rolling and adhesion of leukocytes to the endothelium is increased. We either injected acridine orange using a jugular catheter or directly though the tail vein and compared the amount of rolling and adhering cells. We found that jugular catheter implantation per se increased the number of rolling and adhering LysM+ cells in sham-infused LysMCre+IRG+ mice compared to controls. This activation was augmented in AngII-infused mice. Interestingly, injecting acridine orange directly through the tail vein did not increase LysM+ cell adhesion or rolling in sham-infused mice. We thereby demonstrated the importance of transgenic reporter mice expressing fluorescent proteins to not interfere with in vivo processes during experimentation. Furthermore, tail vein injection of fluorescent tracers might be a possible alternative to jugular catheter injections.
The SecA2 pathway of Mycobacterium tuberculosis exports effectors that work in concert to arrest phagosome and autophagosome maturation

To subvert host defenses, Mycobacterium tuberculosis (Mtb) avoids being delivered to degradative phagolysosomes in macrophages by arresting the normal host process of phagosome maturation. Phagosome maturation arrest by Mtb involves multiple effectors and much remains unknown about this important aspect of Mtb pathogenesis. The SecA2 dependent protein export system is required for phagosome maturation arrest and consequently growth of Mtb in macrophages. To better understand the role of the SecA2 pathway in phagosome maturation arrest, we identified two effectors exported by SecA2 that contribute to this process: the phosphatase SapM and the kinase PknG. Then, utilizing the secA2 mutant of Mtb as a platform to study effector functions, we identified specific steps in phagosome maturation inhibited by SapM and/or PknG. By identifying a histidine residue that is essential for SapM phosphatase activity, we confirmed for the first time that the phosphatase activity of SapM is required for its effects on phagosome maturation in macrophages. We further demonstrated that SecA2 export of SapM and PknG contributes to the ability of Mtb to replicate in macrophages. Finally, we extended our understanding of the SecA2 pathway, SapM, and PknG by revealing that their contribution goes beyond preventing Mtb delivery to mature phagolysosomes and includes inhibiting Mtb delivery to autophagolysosomes. Together, our results revealed SapM and PknG to be two effectors exported by the SecA2 pathway of Mtb with distinct as well as cumulative effects on phagosome and autophagosome maturation. Our results further reveal that Mtb must have additional mechanisms of limiting acidification of the phagosome, beyond inhibiting recruitment of the V-ATPase proton pump to the phagosome, and they indicate differences between effects of Mtb on phagosome and autophagosome maturation.
Normal serum protein electrophoresis and mutated IGHV genes detect very slowly evolving chronic lymphocytic leukemia patients

More than 35 years after the Binet classification, there is still a need for simple prognostic markers in chronic lymphocytic leukemia (CLL). Here, we studied the treatment‐free survival (TFS) impact of normal serum protein electrophoresis (SPE) at diagnosis. One hundred twelve patients with CLL were analyzed. The main prognostic factors (Binet stage; lymphocytosis; IGHV mutation status; TP53, SF3B1, NOTCH1, and BIRC3 mutations; and cytogenetic abnormalities) were studied. The frequencies of IGHV mutation status, cytogenetic abnormalities, and TP53, SF3B1, NOTCH1, and BIRC3 mutations were not significantly different between normal and abnormal SPE. Normal SPE was associated with Binet stage A, nonprogressive disease for 6 months, lymphocytosis below 30 G/L, and the absence of the IGHV3‐21 gene rearrangement which is associated with poor prognosis. The TFS of patients with normal SPE was significantly longer than that of patients with abnormal SPE (log‐rank test: P = 0.0015, with 51% untreated patients at 5.6 years and a perfect plateau afterward vs. a median TFS at 2.64 years for abnormal SPE with no plateau). Multivariate analysis using two different Cox models and bootstrapping showed that normal SPE was an independent good prognostic marker for either Binet stage, lymphocytosis, or IGHV mutation status. TFS was further increased when both normal SPE and mutated IGHV were present (log‐rank test: P = 0.008, median not reached, plateau at 5.6 years and 66% untreated patients). A comparison with other prognostic markers suggested that normal SPE could reflect slowly advancing CLL disease. Altogether, our results show that a combination of normal SPE and mutated IGHV genes defines a subgroup of patients with CLL who evolve very slowly and who might never need treatment.
Recent Asian origin of chytrid fungi causing global amphibian declines

Panzootic chytrid fungus out of Asia Species in the fungal genus Batrachochytrium are responsible for severe declines in the populations of amphibians globally. The sources of these pathogens have been uncertain. O'Hanlon et al. used genomics on a panel of more than 200 isolates to trace the source of the frog pathogen B. dendrobatidis to a hyperdiverse hotspot in the Korean peninsula (see the Perspective by Lips). Over the past century, the trade in amphibian species has accelerated, and now all lineages of B. dendrobatidis occur in traded amphibians; the fungus has become ubiquitous and is diversifying rapidly. Science, this issue p. 621; see also p. 604 The chytrid fungus responsible for global amphibian declines originated in the Korean peninsula and spread during the past century by human trade. Globalized infectious diseases are causing species declines worldwide, but their source often remains elusive. We used whole-genome sequencing to solve the spatiotemporal origins of the most devastating panzootic to date, caused by the fungus Batrachochytrium dendrobatidis, a proximate driver of global amphibian declines. We traced the source of B. dendrobatidis to the Korean peninsula, where one lineage, BdASIA-1, exhibits the genetic hallmarks of an ancestral population that seeded the panzootic. We date the emergence of this pathogen to the early 20th century, coinciding with the global expansion of commercial trade in amphibians, and we show that intercontinental transmission is ongoing. Our findings point to East Asia as a geographic hotspot for B. dendrobatidis biodiversity and the original source of these lineages that now parasitize amphibians worldwide.
Finite element methods for the non‐linear mechanics of crystalline sheets and nanotubes

The formulation and finite element implementation of a finite deformation continuum theory for the mechanics of crystalline sheets is described. This theory generalizes standard crystal elasticity to curved monolayer lattices by means of the exponential Cauchy–Born rule. The constitutive model for a two‐dimensional continuum deforming in three dimensions (a surface) is written explicitly in terms of the underlying atomistic model. The resulting hyper‐elastic potential depends on the stretch and the curvature of the surface, as well as on internal elastic variables describing the rearrangements of the crystal within the unit cell. Coarse grained calculations of carbon nanotubes (CNTs) are performed by discretizing this continuum mechanics theory by finite elements. A smooth discrete representation of the surface is required, and subdivision finite elements, proposed for thin‐shell analysis, are used. A detailed set of numerical experiments, in which the continuum/finite element solutions are compared to the corresponding full atomistic calculations of CNTs, involving very large deformations and geometric instabilities, demonstrates the accuracy of the proposed approach. Simulations for large multi‐million systems illustrate the computational savings which can be achieved. Copyright © 2003 John Wiley & Sons, Ltd.
MARRIAGE AND DELINQUENCY: A POSTSCRIPT

Delinquency Status (at 24th birthday) against Age at Marriage (among the 297 males of the Cambridge Study in Delinquent Development sample, who were still alive and in the United Kingdom at the 22nd birthday). Total with a Percentage with conviction for a conviction offence for offence between 17th between 17 Total Total Percentage and 24th and 24th males delinquents delinquents birthdays birthdays Married before 21st birthday 77* 26f 33-8 19 24'7 Married at age 21 or 22 82 28f 34-i 23 28-0