Miracle-dz/UniFAR-FTUs huggingface dataset:
‘Running with the Fox and Hunting with the Hounds’: Social Work Tutors' Experiences of Managing Failing Social Work Students in Practice Learning Settings

The paper explores the issues raised by social work students failing in practice learning settings from the perspective of university tutors, by drawing on existing literature in this area from social work and nursing, as well as findings from a small‐scale empirical qualitative study. The qualitative study was influenced by practitioner‐researcher and practice‐near paradigms; and is based on interviews with twelve social work tutors in England. The findings reveal that tutors are able to articulate the important tasks and functions of their roles when issues of failing students in practice learning settings arise, although the process can be challenging. The challenges include: supporting practice educator and student, concerns about other tutors’ practices, the difficulties in promoting appropriate professional standards and values within higher education contexts and frustrations with practice educators and placements. Only a third of the respondents (four) however, articulated their gate keeping roles and responsibilities although this was not without its difficulties. Given the current reforms in social work education in England at this present time, with greater emphasis on threshold standards at entry level, and at key stages throughout the programme of study, the research is timely in terms of the critical consideration of the tutor role and challenges inherent in promoting appropriate standards.
Shorter term aerobic exercise improves brain, cognition, and cardiovascular fitness in aging

Physical exercise, particularly aerobic exercise, is documented as providing a low cost regimen to counter well-documented cognitive declines including memory, executive function, visuospatial skills, and processing speed in normally aging adults. Prior aging studies focused largely on the effects of medium to long term (>6 months) exercise training; however, the shorter term effects have not been studied. In the present study, we examined changes in brain blood flow, cognition, and fitness in 37 cognitively healthy sedentary adults (57–75 years of age) who were randomized into physical training or a wait-list control group. The physical training group received supervised aerobic exercise for 3 sessions per week 1 h each for 12 weeks. Participants' cognitive, cardiovascular fitness and resting cerebral blood flow (CBF) were assessed at baseline (T1), mid (T2), and post-training (T3). We found higher resting CBF in the anterior cingulate region in the physical training group as compared to the control group from T1 to T3. Cognitive gains were manifested in the exercise group's improved immediate and delayed memory performance from T1 to T3 which also showed a significant positive association with increases in both left and right hippocampal CBF identified earlier in the time course at T2. Additionally, the two cardiovascular parameters, VO2 max and rating of perceived exertion (RPE) showed gains, compared to the control group. These data suggest that even shorter term aerobic exercise can facilitate neuroplasticity to reduce both the biological and cognitive consequences of aging to benefit brain health in sedentary adults.
Stereo Vision Enhancements for Low-Cost Outdoor Autonomous Vehicles

The contemporary implementation of software systems for offroad navigation on conventional computing involves a continuous struggle to develop more computationally efficient algorithms. A basic trade-off exists between system performance and reliability for any given level of efficiency of the software. Hence, the only way to improve both performance and reliability is to improve the computational efficiency of the underlying algorithms. Dense stereo vision algorithms can easily exhaust almost all available computer cycles and are therefore prime candidates for the development of more efficient approaches. This paper presents some techniques that can be used to improve the efficiency and/or reliability of dense stereo for off road autonomous vehicles.
Characterization of Efflux Transporters Involved in Distribution and Disposition of Apixaban

The studies reported here were conducted to investigate the transport characteristics of apixaban (1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide) and to understand the impact of transporters on apixaban distribution and disposition. In human permeability glycoprotein (P-gp)- and breast cancer resistance protein (BCRP)-cDNA–transfected cell monolayers as well as Caco-2 cell monolayers, the apparent efflux ratio of basolateral-to-apical (PcB-A) versus apical-to-basolateral permeability (PcA-B) of apixaban was >10. The P-gp- and BCRP-facilitated transport of apixaban was concentration- and time-dependent and did not show saturation over a wide range of concentrations (1–100 μM). The efflux transport of apixaban was also demonstrated by the lower mucosal-to-serosal permeability than that of the serosal-to-mucosal direction in isolated rat jejunum segments. Apixaban did not inhibit digoxin transport in Caco-2 cells. Ketoconazole decreased the P-gp-mediated apixaban efflux in Caco-2 and the P-gp-cDNA–transfected cell monolayers, but did not affect the apixaban efflux to a meaningful extent in the BCRP-cDNA–transfected cell monolayers. Coincubation of a P-gp inhibitor (ketoconazole or cyclosporin A) and a BCRP inhibitor (Ko134) provided more complete inhibition of apixaban efflux in Caco-2 cells than separate inhibition by individual inhibitors. Naproxen inhibited apixaban efflux in Caco-2 cells but showed only a minimal effect on apixaban transport in the BCRP-transfected cells. Naproxen was the first nonsteroidal antiinflammatory drug that was demonstrated as a weak P-gp inhibitor. These results demonstrate that apixaban is a substrate for efflux transporters P-gp and BCRP, which can help explain its low brain penetration, and low fetal exposures and high milk excretion in rats.
Design recommendations for a reliable body-worn patient monitoring and alarming service

Telehealth has been widely used in recent years to provide healthcare services at a distance. It supports eliminating space barriers and improves access to healthcare services. One important feature of telehealth is that it can be used to save lives in critical and emergency situations by means of alarming service. As health monitoring and alarming services rely quite heavily on body-worn devices/sensors for health-related patient data gathering, communications reliability between those devices and back-end monitoring and alarming server is of high importance to be taken into consideration during the design phase of such services. A slight miscalculation may cost precious human lives. This paper aims to provide design recommendations for a reliable patient monitoring and alarming service that gathers patient data mainly through body-worn sensors.
Causality in acute encephalitis: defining aetiologies

SUMMARY Defining the causal relationship between a microbe and encephalitis is complex. Over 100 different infectious agents may cause encephalitis, often as one of the rarer manifestations of infection. The gold-standard techniques to detect causative infectious agents in encephalitis in life depend on the study of brain biopsy material; however, in most cases this is not possible. We present the UK perspective on aetiological case definitions for acute encephalitis and extend them to include immune-mediated causes. Expert opinion was primarily used and was supplemented by literature-based methods. Wide usage of these definitions will facilitate comparison between studies and result in a better understanding of the causes of this devastating condition. They provide a framework for regular review and updating as the knowledge base increases both clinically and through improvements in diagnostic methods. The importance of new and emerging pathogens as causes of encephalitis can be assessed against the principles laid out here.
Reinnervation of Late Postnatal Purkinje Cells by Climbing Fibers: Neosynaptogenesis without Transient Multi-Innervation

Synaptic partner selection and refinement of projections are important in the development of precise and functional neuronal connections. We investigated the formation of new synaptic connections in a relatively mature system to test whether developmental events can be recapitulated at later stages (i.e., after the mature synaptic organization has been established), using a model of postlesional reinnervation in the olivo-cerebellar pathway. During the development of this pathway, synaptic connections between climbing fibers (CFs) and Purkinje cells (PCs) are diffuse and redundant before synapse elimination refines the pattern. The regression of CFs during the first 2 postnatal weeks in the rat leads to mono-innervation of each PC. After unilateral transection of the rat olivo-cerebellar pathway and intracerebellar injection of BDNF 24 h after lesion, axons from the remaining inferior olive can sprout into the deafferented hemicerebellum and establish new contacts with denervated PCs at later developmental stages. We found that these contacts are first established on somatic thorns before the CFs translocate to the PC dendrites, recapitulating the morphological steps of normal CF–PC synaptogenesis, but on a relatively mature PC. However, electrophysiology of PC reinnervation by transcommissural CFs in these animals showed that each PC is reinnervated by only one CF. This mono-innervation contrasts with the reinnervation of grafted immature PCs in the same cerebellum. Our results provide evidence that relatively mature PCs do not receive several olivary afferents during late reinnervation, suggesting a critical role of the target cell state in the control of CF–PC synaptogenesis. Thus, synapse exuberance and subsequent elimination are not a prerequisite to reach a mature relationship between synaptic partners.
Gene Discovery through Genomic Sequencing of Brucella abortus

ABSTRACT Brucella abortus is the etiological agent of brucellosis, a disease that affects bovines and human. We generated DNA random sequences from the genome of B. abortus strain 2308 in order to characterize molecular targets that might be useful for developing immunological or chemotherapeutic strategies against this pathogen. The partial sequencing of 1,899 clones allowed the identification of 1,199 genomic sequence surveys (GSSs) with high homology (BLAST expect value < 10−5) to sequences deposited in the GenBank databases. Among them, 925 represent putative novel genes for the Brucella genus. Out of 925 nonredundant GSSs, 470 were classified in 15 categories based on cellular function. Seven hundred GSSs showed no significant database matches and remain available for further studies in order to identify their function. A high number of GSSs with homology toAgrobacterium tumefaciens and Rhizobium meliloti proteins were observed, thus confirming their close phylogenetic relationship. Among them, several GSSs showed high similarity with genes related to nodule nitrogen fixation, synthesis of nod factors, nodulation protein symbiotic plasmid, and nodule bacteroid differentiation. We have also identified severalB. abortus homologs of virulence and pathogenesis genes from other pathogens, including a homolog to both the Shda gene fromSalmonella enterica serovar Typhimurium and the AidA-1 gene from Escherichia coli. Other GSSs displayed significant homologies to genes encoding components of the type III and type IV secretion machineries, suggesting that Brucella might also have an active type III secretion machinery.
A Van Benthem Theorem for Modal Team Semantics

The famous van Benthem theorem states that modal logic corresponds exactly to the fragment of first-order logic that is invariant under bisimulation. In this article we prove an exact analogue of this theorem in the framework of modal dependence logic (MDL) and team semantics. We show that Modal Team Logic (MTL) extending MDL by classical negation captures exactly the FO-definable bisimulation invariant properties of Kripke structures and teams. We also compare the expressive power of MTL to most of the variants and extensions of MDL recently studied in the area.
The Identification of Primary Sites of Superoxide and Hydrogen Peroxide Formation in the Aerobic Respiratory Chain and Sulfite Reductase Complex of Escherichia coli *

The fitness of organisms depends upon the rate at which they generate superoxide (O·̄2) and hydrogen peroxide (H2O2) as toxic by-products of aerobic metabolism. In Escherichia coli these oxidants arise primarily from the autoxidation of components of its respiratory chain. Inverted vesicles that were incubated with NADH generated O·̄2and H2O2 at accelerated rates either when treated with cyanide or when devoid of quinones, implicating an NADH dehydrogenase as their source. Null mutations in the gene encoding NADH dehydrogenase II averted autoxidation of vesicles, and its overproduction accelerated it. Thus NADH dehydrogenase II but not NADH dehydrogenase I, respiratory quinones, or cytochrome oxidases formed substantial O·̄2 and H2O2. NADH dehydrogenase II that was purified from both wild-type and quinone-deficient cells generated ∼130 H2O2and 15 O·̄2 min−1 by autoxidation of its reduced FAD cofactor. Sulfite reductase is a second autoxidizable electron transport chain of E. coli, containing FAD, FMN, [4Fe-4S], and siroheme moieties. Purified flavoprotein that contained only the FAD and FMN cofactors had about the same oxidation turnover number as did the holoenzyme, 7 min−1 FAD−1. Oxidase activity was largely lost upon FMN removal. Thus the autoxidation of sulfite reductase, like that of the respiratory chain, occurs primarily by autoxidation of an exposed flavin cofactor. Great variability in the oxidation turnover numbers of these and other flavoproteins suggests that endogenous oxidants will be predominantly formed by only a few oxidizable enzymes. Thus the degree of oxidative stress in a cell may depend upon the titer of such enzymes and accordingly may vary with growth conditions and among different cell types. Furthermore, the chemical nature of these reactions was manifested by their acceleration at high temperatures and oxygen concentrations. Thus these environmental parameters may also directly affect the O·̄2 and H2O2 loads that organisms must bear.
Optical Bistability in a Silicon Waveguide Distributed Bragg Reflector Fabry–Pérot Resonator

We demonstrate optical bistability in a silicon waveguide Fabry-Pérot resonator formed by a pair of distributed Bragg reflectors. In the bistable regime, the output power of the resonator ceases to be uniquely determined by the input power because multiple powers within the cavity satisfy the resonance condition. Pulsating behavior is observed within the resonator output, and is attributed to noise within the experimental setup driving the resonator between the multiple allowed output powers.
Divergent susceptibilities of human herpesvirus 6 variants to type I interferons

Two distinct human herpesvirus 6 (HHV-6) variants infect humans. HHV-6B is the etiologic agent of roseola and is associated with life-threatening neurological diseases, such as encephalitis, as well as organ transplant failure. The epidemiology and disease association for HHV-6A remain ill-defined. Specific anti-HHV-6 drugs do not exist and classic antiherpes drugs have secondary effects that are often problematic for transplant patients. Clinical trials using IFN were also performed with inconclusive results. We investigated the efficacy of type I IFN (α/β) in controlling HHV-6 infection. We report that cells infected with laboratory strains and primary isolates of HHV-6B are resistant to IFN-α/β antiviral actions as a result of improper IFN-stimulated gene (ISGs) expression. In contrast, HHV-6A-infected cells were responsive to IFN-α/β with pronounced antiviral effects observed. Type II IFN (γ)-signaling was unaltered in cells infected by either variant. The HHV-6B immediate-early 1 (IE1) physically interacts with STAT2 and sequestrates it to the nucleus. As a consequence, IE1B prevents the binding of ISGF3 to IFN-responsive gene promoters, resulting in ISG silencing. In comparison, HHV-6A and its associated IE1 protein displayed marginal ISG inhibitory activity relative to HHV-6B. The ISG inhibitory domain of IE1B mapped to a 41 amino acid region absent from IE1A. Transfer of this IE1B region resulted in a gain of function that conferred ISG inhibitory activity to IE1A. Our work is unique in demonstrating type I IFN signaling defects in HHV-6B-infected cells and highlights a major biological difference between HHV-6 variants.
“We Are Drowning in Red Beet, Patching Up the Holes in the Iron Curtain”: The Punk Subculture in Ljubljana in the Late 1970s and Early 1980s

[This article discusses the phenomenon of punk in Ljubljana, the capital of Slovenia, from its beginnings in the early 1970s to its heyday in early 1980s and its subsequent differentiation and dissolution in a wider alternative scene. The subject is thereby being treated primarily as a genre of protest music and as a youth subculture. A special focus is given to the harsh reactions on part of the communist regime, in particular the 1981 “Nazi punk affair,” and the strong political significance punk thus came to possess—albeit to a large extent unintentionally. Excerpts of lyrics from Ljubljana punk rock bands are also presented, pointing to the attitudes of the punk youth towards their social environment and political situation and revealing how they came to be seen as a threat to the socialist order. In the conclusion, the sociopolitical legacy of punk and certain controversies surrounding it are shortly touched upon. , This article discusses the phenomenon of punk in Ljubljana, the capital of Slovenia, from its beginnings in the early 1970s to its heyday in early 1980s and its subsequent differentiation and dissolution in a wider alternative scene. The subject is thereby being treated primarily as a genre of protest music and as a youth subculture. A special focus is given to the harsh reactions on part of the communist regime, in particular the 1981 “Nazi punk affair,” and the strong political significance punk thus came to possess—albeit to a large extent unintentionally. Excerpts of lyrics from Ljubljana punk rock bands are also presented, pointing to the attitudes of the punk youth towards their social environment and political situation and revealing how they came to be seen as a threat to the socialist order. In the conclusion, the sociopolitical legacy of punk and certain controversies surrounding it are shortly touched upon. ]
Metabolic stress, IAPP and islet amyloid

Amyloid forms within pancreatic islets in type 2 diabetes from aggregates of the β‐cell peptide islet amyloid polypeptide (IAPP). These aggregates are toxic to β‐cells, inducing β‐cell death and dysfunction, as well as inciting islet inflammation. The β‐cell is subject to a number of other stressors, including insulin resistance and hyperglycaemia, that may contribute to amyloid formation by increasing IAPP production by the β‐cell. β‐Cell dysfunction, evident as impaired glucose‐stimulated insulin secretion and defective prohormone processing and exacerbated by metabolic stress, is also a likely prerequisite for islet amyloid formation to occur in type 2 diabetes. Islet transplants in patients with type 1 diabetes face similar stressors, and are subject to rapid amyloid formation and impaired proinsulin processing associated with progressive loss of β‐cell function and mass. Declining β‐cell mass is predicted to increase metabolic demand on remaining β‐cells, promoting a feed‐forward cycle of β‐cell decline.
Research in School Library Media for the Next Decade: Polishing the Diamond

Over the next decade, research in school library media should focus explicitly on the relationship between library media programs and student learning. Attention to this topic has been a growing theme in the field's research for decades, and a number of factors argue for making it even more central in the coming years: the increasing emphasis on learning and achievement throughout education; the deepening appreciation for the library media specialist's various roles as they relate to this emphasis on learning; the emergence of electronic information resources that highlight the relationship between learning and information use as never before; and the publication of the Information Literacy Skills for Student Learning in Information Power: Building Partnerships for Learning (American Association of School Librarians and Association for Educational Communications and Technology [AASL and AECT], 1998). These statements of learning outcomes related to information use tie the school library media field directly to learning as nothing has done before. They provide both a rationale and a conceptual framework for studying students' interactions with information as the kind of authentic learning that is the goal of education in the twenty-first century.
The Development of Sport Expertise: Mapping the Tactical Domain

This article explores issues and research relevant to sport tactical knowledge development and expertise. A discussion of the controversies concerning methodological tools is accompanied by a presentation of the possible levels of analysis (continua) in sport research. Theories of knowledge development and a protocol structure model for sport tactical knowledge are included. Knowledge development trends based on expert-novice cross-sectional research are presented, followed by longitudinal research exploring issues of instruction and player development. A concluding discussion concerns the role of tactical knowledge in contemporary motor skill theory and limitations of learning and instruction theory.
Presence‐Only Data and the EM Algorithm

Summary In ecological modeling of the habitat of a species, it can be prohibitively expensive to determine species absence. Presence‐only data consist of a sample of locations with observed presences and a separate group of locations sampled from the full landscape, with unknown presences. We propose an expectation–maximization algorithm to estimate the underlying presence–absence logistic model for presence‐only data. This algorithm can be used with any off‐the‐shelf logistic model. For models with stepwise fitting procedures, such as boosted trees, the fitting process can be accelerated by interleaving expectation steps within the procedure. Preliminary analyses based on sampling from presence–absence records of fish in New Zealand rivers illustrate that this new procedure can reduce both deviance and the shrinkage of marginal effect estimates that occur in the naive model often used in practice. Finally, it is shown that the population prevalence of a species is only identifiable when there is some unrealistic constraint on the structure of the logistic model. In practice, it is strongly recommended that an estimate of population prevalence be provided.