Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinicopathologic Characteristics and Outcomes of Histiocytic and Dendritic Cell Neoplasms: The Moffitt Cancer Center Experience Over the Last Twenty Five Years

Neoplasms of histiocytic and dendritic cells are rare disorders of the lymph node and soft tissues. Because of this rarity, the corresponding biology, prognosis and terminologies are still being better defined and hence historically, these disorders pose clinical and diagnostic challenges. These disorders include Langerhans cell histiocytosis (LCH), histiocytic sarcoma (HS), follicular dendritic cell sarcoma (FDCS), interdigtating cell sarcoma (IDCS), indeterminate cell sarcoma (INDCS), and fibroblastic reticular cell tumors (FRCT). In order to gain a better understanding of the biology, diagnosis, and treatment in these rare disorders we reviewed our cases of these neoplasms over the last twenty five years and the pertinent literature in each of these rare neoplasms. Cases of histiocytic and dendritic cell neoplasms diagnosed between 1989–2014 were identified using our institutional database. Thirty two cases were included in this analysis and were comprised of the following: Langerhans cell histiocytosis (20/32), histiocytic sarcoma (6/32), follicular dendritic cell sarcoma (2/32), interdigitating dendritic cell sarcoma (2/32), indeterminate dendritic cell sarcoma (1/32), and fibroblastic reticular cell tumor (1/32). Median overall survival was not reached in cases with LCH and showed 52 months in cases with HS, 12 months in cases with FDCS, 58 months in cases with IDCS, 13 months in the case of INDCS, and 51 months in the case of FRCT. The majority of patients had surgical resection as initial treatment (n = 18). Five patients had recurrent disease. We conclude that histiocytic and dendritic cell neoplasms are very rare and perplexing disorders that should be diagnosed with a combination of judicious morphology review and a battery of immunohistochemistry to rule out mimics such as carcinoma, lymphoma, neuroendocrine tumors and to better sub-classify these difficult to diagnose lesions. The mainstay of treatment for localized disease remains surgical resection and the role of adjuvant therapy is unclear. In patients with multiple areas of involvement, treatment at tertiary care centers with multimodality treatment is likely needed. Accurate subset diagnosis will contribute to better data as well as treatment outcomes analysis of these rare disorders of adult patients in the future.
[Immunol reconstitution after autologous purified CD34+ cells transplantation in patients with systemic lupus erythematosus].

OBJECTIVE To investigate the variation of immune index in patients with systemic lupus erythematosus (SLE) treated with autologous purified CD34+ cells transplantation and to clarify the relationship with pathogenesis and prognosis. METHODS Flow cytometry (FCM) and enzyme linked immunosorbent assay (ELISA) were used to test lymphocyte subsets, C3, C4, CH50, autoantibodies and immunoglobulin for 18 cases of SLE before and after transplantation. RESULTS The results showed that the ratio of all the T cell subsets reduced obviously in early post graft and recovered gradually in 1 to 3 months after transplantation except CD45RO(+)CD4(+) cells. The levels of serum C3, C4, CH50 increased significantly after transplantation. No case relapsed within one year after transplantation, but 2 patients relapsed one year after transplantation. The levels of the indexes in the patients with relapse were significantly lower than those in the patients with persistent remission, including C(4) in the entire course, CH(50) in the 3rd and 12th month after transplantation and CD(45)RA(+)CD(8)+ cells in the 6th month after transplantation. However, the ratio of CD45RO(+)CD(4)+ cells in the first month after transplantation in the patients with relapse was higher than that in the patients with persistent remission. CONCLUSION Autologous purified CD(34)+ cells transplantation is effective for treating SLE. Survey of immune indexes before and after transplantation is important to investigate the pathogenesis of SLE. Moreover, these immune indexes can be used to predict therapeutic efficacy of SLE.
Extracellular Antigens from Listeria monocytogenes I. Purification and Resolution of Hemolytic and Lipolytic Antigens from Culture Filtrates of Listeria monocytogenes

Two antigens were purified from culture filtrates of Listeria monocytogenes 7973 by the following procedure: (i) acid precipitation with 4 n HCl at pH 3.7, (ii) Sephadex G-75 column fractionation, (iii) diethylaminoethyl-Sephadex A50 batchwise adsorption, and (iv) rechromatography on Sephadex G-75. This procedure resulted in the resolution of two distinct antigens. One antigen, designated a hemolytic antigen because of its ability to lyse erythrocytes from a variety of species, had a specific activity of 25,000 units/mg of protein and an estimated molecular weight of at least 171,000. The other antigen, designated a lipolytic antigen because of its ability to hydrolyze egg yolk saline substrate, had a specific activity of 400 units/mg of protein and an estimated molecular weight of 52,500.
Design Strategy of Serial Manipulators With Certified Constraint Satisfaction

This paper presents the design strategy of serial manipulators with constraint satisfaction. The algorithm provides certified solutions to the range of values of the manipulator design parameters that satisfy the given constraints for all points inside a desired workspace. Alternatively, it can also be used to obtain the achievable workspace of a particular manipulator topology within which a set of given constraints are satisfied. This strategy can therefore be applied to the general case of a serial manipulator design problem, robots of adjustable parameters, or even reconfigurable robot strategy to obtain a suitable topology. The interval-based algorithm was implemented on an example serial anthropomorphic manipulator with joint displacement constraints and obtains the possible variations to the manipulator topology that allow the required workspace to be achievable under the given joint displacement constraints. Results are presented and discussed.
Brain metastasis in lung cancer

Summary FDG-PET/CT is increasingly used in staging of lung cancer as single „one stop shop” method. Aim, patients, methods: We prospectively included 104 neurological asymptomatic patients (65 years, 26% women) with primary diagnosis of lung cancer. In all patients PET/CT including cerebral imaging and cerebral MRI were performed. Results: Diagnosis of brain metastases (BM) was made by PET/CT in 8 patients only (7.7%), by MRI in 22 (21.2%). In 80 patients both PET/CT and MRI showed no BM. In 6 patients (5.8%) BM were detectable on PET/CT as well as on MRI. Exclusive diagnosis of BM by MRI with negative finding on PET/CT was present in 16 patients (15.4%). 2 patients (1.9%) had findings typical for BM on PET/CT but were negative on MRI. With MRI overall 100 BM were detected, with PET/CT only 17 BM (p < 0.01). For the diagnosis of BM PET/CT showed a sensitivity of 27.3%, specificity of 97.6%, positive predictive value of 75% and negative predictive value of 83.3%. BM diameter on PET/CT and MRI were consistent in 43%, in 57% BM were measured larger on MRI. Discussion: Compared to the gold standard of MRI for cerebral staging a considerable number of patients are falsely diagnosed as free from BM by PET/CT. MRI is more accurate than PET/CT for detecting multiple and smaller BM. Conclusion: In patients with a curative option MRI should be performed additionally to PET/CT for definitive exclusion of brain metastases.
Lack of mitochondrial DNA variation in Australian Drosophila buzzatii.

Drosophila buzzatii is native to Argentina and Brazil and was introduced to Australia, probably between 193 1 and 1936, during the biological control program for prickly pear cacti (Opuntia spp.) (Mann 1970; Barker 1982; Barker et al. 1985). It lives and breeds in rotting tissues of prickly pear and apparently is restricted to this niche (Barker and Mulley 1976 ) . Populations of D. buzzatii in Australia occur in islands corresponding to patches of Opuntia. Before the introduction of the moth Cactoblastis cactorum as a biological control agent, prickly pears formed a nearly continuous distribution throughout much of Queensland and northern New South Wales ( fig. 1) . Cactoblastis cactorum rapidly reduced the distribution of Opuntia to isolated patches (Dodd 1940; Mann 1970); consequently, the distribution of D. buzzatii is restricted to these same patches. The sizes of the populations, as well as their degree of isolation, vary widely. Barker and Mulley ( 1976) and Barker ( 198 1) found low levels of allozyme variation in Australian D. buzzatii. They compared their results with those for related species and concluded that low levels of allozyme variation may be typical of the mulleri subgroup and that their data did not necessarily indicate a founder effect at the time of introduction to Australia. In this report we present the results of a survey of mitochondrial DNA (mtDNA) restriction-site variation in Australian D. buzzatii and conclude that lack of variation is probably due to the founder effect. We studied 25 isofemale lines established from wild caught females. The 25 lines represented nine populations from throughout the Australian range of D. buzzatii (fig. 1). Flies were maintained in the laboratory on cactus-sucrose-yeast medium (Starmer and Barker 1986). mtDNA extraction followed the procedure of Tamura and Aotsuka ( 1988 ) , with minor modifications. mtDNA was digested with 12 restriction enzymes ( AvaII, BarnHI, BgZII, ClaI, EcoRI, EcoRV, HaeIII, HindIII, Hid, HpaII, PstI, and XhoI). Fragments were separated in 0.8% agarose gels, were transferred to charged nylon membranes by Southern blotting, and were probed with mtDNA isolated as above and labeled with digoxigenin-dUTP ( Boehringer Mannheim) . Bands were visualized by using the DNA Detection Kit (Boehringer Mannheim) . Sizes of bands were estimated either graphically or by using the computer program of Halliburton ( 199 1). Forty-two restriction sites were detected, representing 1.3% of the mtDNA molecule. The sum of fragment sizes was 15.8-16.5 kb for different enzymes. The smaller figures probably indicate undetected small ( ~300 bp) fragments. No size variation or restriction-site variation was detected. All lines showed the same pattern for a given enzyme. The most reasonable explanation for the lack of variation in Australian D. buzzatii is that it indicates a founder effect at the time when the species colonized Australia. Other evidence is consistent with this hypothesis. Allozyme studies (for the same set
Comparison of Serratus Anterior Plane Block by Anatomical Landmark-Guided Technique Versus Ultrasound-guided Technique for Gynaecomastia Surgery: A Randomized Controlled Trial

Background: Breast surgeries are common surgical procedures and postoperative pain after mastectomy is a major concern as inadequate pain relief can result in chronic pain and reduced quality of life. Serratus anterior plane (SAP) block is suitable for perioperative analgesia for gynaecomastia correction surgery. Objectives: To compare postoperative pain relief using the VAS and D-VAS scores between anatomical landmark-guided SAP block and ultrasound-guided SAP block in patients undergoing surgery for gynecomastia correction. Methods: Patients aged 16-40 years, belonging to American Society of Anaesthesiologists (ASA) physical status I or II who were scheduled for gynaecomastia correction surgery were randomized and allocated into two groups. Group I (n = 15) patients received 20 ml of 0.25 % bupivacaine solution with 20 μg of Fentanyl by anatomical landmark-guided SAP technique while Group II (n = 15) patients in the control group received same drug using ultrasound-guidance technique. VAS and D-VAS from arrival to post anaesthesia care unit (PACU), then after 30 minutes, and at 1 hour, 2 hours, 6 hours, 12 hours, 18 hours, and 24 hours. Results: Both groups had comparable results in terms of pain scores at different time intervals, duration of analgesia (615 mins vs 706 mins) and need for rescue analgesics. Conclusion: Anatomical landmark-based SAP block technique is comparable to the ultrasound-guided SAP block technique in terms of efficacy and duration of analgesia with lesser complications. The former can serve as an alternative to the latter technique in resource-limited countries.
Understanding block-level address usage in the visible internet

Although the Internet is widely used today, we have little information about the edge of the network. Decentralized management, firewalls, and sensitivity to probing prevent easy answers and make measurement difficult. Building on frequent ICMP probing of 1% of the Internet address space, we develop clustering and analysis methods to estimate how Internet addresses are used. We show that adjacent addresses often have similar characteristics and are used for similar purposes (61% of addresses we probe are consistent blocks of 64 neighbours or more). We then apply this block-level clustering to provide data to explore several open questions in how networks are managed. First, we provide information about how effectively network address blocks appear to be used, finding that a significant number of blocks are only lightly used (most addresses in about one-fifth of 24 blocks are in use less than 10% of the time), an important issue as the IPv4 address space nears full allocation. Second, we provide new measurements about dynamically managed address space, showing nearly 40% of 24 blocks appear to be dynamically allocated, and dynamic addressing is most widely used in countries more recent to the Internet (more than 80% in China, while less than 30% in the U.S.). Third, we distinguish blocks with low-bitrate last-hops and show that such blocks are often underutilized.
Camera Models and algorithms for 3D video content creation. (Modèles de caméras et algorithmes pour la création de contenu video 3D)

Optics with long focal length have been extensively used for shooting 2D cinema and television, either to virtually get closer to the scene or to produce an aesthetical effect through the deformation of the perspective. However, in 3D cinema or television, the use of long focal length either creates a “cardboard effect” or causes visual divergence. To overcome this problem, state-of-the-art methods use disparity mapping techniques, which is a generalization of view interpolation, and generate new stereoscopic pairs from the two image sequences. We propose to use more than two cameras to solve for the remaining issues in disparity mapping methods.In the first part of the thesis, we review the causes of visual fatigue and visual discomfort when viewing a stereoscopic film. We then model the depth perception from stereopsis of a 3D scene shot with two cameras, and projected in a movie theater or on a 3DTV. We mathematically characterize this 3D distortion, and derive the mathematical constraints associated with the causes of visual fatigue and discomfort. We illustrate these 3D distortions with a new interactive software, “The Virtual Projection Room”. In order to generate the desired stereoscopic images, we propose to use image-based rendering. Those techniques usually proceed in two stages. First, the input images are warped into the target view, and then the warped images are blended together. The warps are usually computed with the help of a geometric proxy (either implicit or explicit). Image blending has been extensively addressed in the literature and a few heuristics have proven to achieve very good performance. Yet the combination of the heuristics is not straightforward, and requires manual adjustment of many parameters.In this thesis, we propose a new Bayesian approach to the problem of novel view synthesis, based on a generative model taking into account the uncertainty of the image warps in the image formation model. The Bayesian formalism allows us to deduce the energy of the generative model and to compute the desired images as the Maximum a Posteriori estimate. The method outperforms state-of-the-art image-based rendering techniques on challenging datasets. Moreover, the energy equations provide a formalization of the heuristics widely used in image-based rendering techniques. Besides, the proposed generative model also addresses the problem of super-resolution, allowing to render images at a higher resolution than the initial ones.In the last part of this thesis, we apply the new rendering technique to the case of the stereoscopic zoom and show its performance.
Image segmentation and pattern matching based FPGA/ASIC implementation architecture of real-time object tracking

A novel algorithm for object tracking of video pictures, based on image segmentation and pattern matching as well as its FPGA/ASIC implementation architecture are presented. With image segmentation, we can detect all objects in the images no matter whether they are moving or not. Using image segmentation results of successive frames, we exploit pattern matching in a simple object feature space for tracking of objects. The proposed algorithm can be applied to multiple moving and still objects even in the case of a moving camera. The FPGA/ASIC implementation architecture is verified to enable real-time tracking of up to 220 objects, when realized with modern FPGA hardware.
Beyond Sentential Semantic Parsing: Tackling the Math SAT with a Cascade of Tree Transducers

We present an approach for answering questions that span multiple sentences and exhibit sophisticated cross-sentence anaphoric phenomena, evaluating on a rich source of such questions – the math portion of the Scholastic Aptitude Test (SAT). By using a tree transducer cascade as its basic architecture, our system propagates uncertainty from multiple sources (e.g. coreference resolution or verb interpretation) until it can be confidently resolved. Experiments show the first-ever results 43% recall and 91% precision) on SAT algebra word problems. We also apply our system to the public Dolphin algebra question set, and improve the state-of-the-art F1-score from 73.9% to 77.0%.
Probing hybridization parameters from microarray experiments: nearest-neighbor model and beyond

In this article, it is shown how optimized and dedicated microarray experiments can be used to study the thermodynamics of DNA hybridization for a large number of different conformations in a highly parallel fashion. In particular, free energy penalties for mismatches are obtained in two independent ways and are shown to be correlated with values from melting experiments in solution reported in the literature. The additivity principle, which is at the basis of the nearest-neighbor model, and according to which the penalty for two isolated mismatches is equal to the sum of the independent penalties, is thoroughly tested. Additivity is shown to break down for a mismatch distance below 5 nt. The behavior of mismatches in the vicinity of the helix edges, and the behavior of tandem mismatches are also investigated. Finally, some thermodynamic outlying sequences are observed and highlighted. These sequences contain combinations of GA mismatches. The analysis of the microarray data reported in this article provides new insights on the DNA hybridization parameters and can help to increase the accuracy of hybridization-based technologies.
Through-Wall Imaging Radar

Abstract : The ability to locate moving targets inside abuilding with a sensor situated at a standoffrange outside the building would greatly improvesituational awareness on the urban battlefield. Aradar imaging system was developed to imagethrough walls, providing a down-range versuscross-range image of all moving targets at avideo frame rate. This system uses an S-band,frequency-modulated, continuous-wave radarwith a spatial frequency range gate coupledto a time-division multiplexed, multiple-input,multiple-output antenna array to rapidly acquire,process, and display radar imagery at a framerate of 10.8 Hz. Maximum expected rangethrough a 20 cm thick, solid concrete wall is20 m. Measurements show that this system canlocate humans (moving or standing still) behind10 and 20 cm thick, solid concrete walls andthrough cinder-block walls.
Mobile Ad Intrusiveness - The Effects of Message Type and Situation

This study addresses the effects of message type and situation on the perceived intrusiveness of mobile advertisements. Ad intrusiveness, as conceptualized by Li et al., is introduced to the field of mobile advertising and used as dependent variable in a 2x2 within-subjects factorial study design. Two message types (informative vs. entertaining) are combined with two different situations (low vs. high level of activity). Attitude towards advertising in general and ad relevance (here: product class involvement) are further variables assessed in order to test for a hypothesized impact on mobile ad intrusiveness. A survey approach was used for data collection (n=325). Main effects were analyzed with analysis of variance. Analysis of covariance and regression analysis were applied subsequently for analyzing further effects. While message type was not found to contribute significantly to the explanation of mobile ad intrusiveness, the situation type showed a highly significant effect. Three of the four assumed relationships were found in the data. The study contributes to the body of knowledge on mobile advertising effectiveness. Empirical evidence for the effects of the situational context on mobile advertising effectiveness has been found and discussed with possible implications for marketing practice.
Optical Analysis of Perovskite III-V Nanowires Interpenetrated Tandem Solar Cells

Multi-junction photovoltaics approaches are being explored to mitigate thermalization losses that occur in the absorption of high-energy photons. However, the design of tandem cells faces challenges such as light reflection and parasitic absorption. Nanostructures have emerged as promising solutions due to their anti-reflection properties, which enhances light absorption. III-V nanowires (NWs) solar cells can achieve strong power conversion efficiencies, offering the advantage of potentially integrating tunnel diodes within the same fabrication process. Metal halide perovskites (MHPs) have gained attention for their optoelectronic attributes and cost-effectiveness. Notably, both material classes allow for tunable bandgaps. This study explores the integration of MHPs with III-V NWs solar cells in both two-terminal and three-terminal configurations. Our primary focus lies in the optical analysis of a tandem design using III-V semiconductor nanowire arrays in combination with perovskites, highlighting their potential for tandem applications. The space offered by the compact footprint of NW arrays is used in an interpenetrated tandem structure. We systematically optimize the bottom cell, addressing reflectivity and parasitic absorption, and extend to a full tandem structure, considering experimentally feasible thicknesses. Simulation of a three-terminal structure highlights a potential increase in efficiency, decoupling the operating points of the subcells. The two-terminal analysis underscores the benefits of nanowires in reducing reflection and achieving a higher matched current between the top and the bottom cells. This research provides significant insights into NW tandem solar cell optics, enhancing our understanding of their potential to improve photovoltaic performance.