Miracle-dz/UniFAR-FTUs huggingface dataset:
Aspekte der Relativsatzextraposition im Deutschen

Looking at relative clause extraposition in German as a concrete example, the paper demonstrates how linguistic model building, corpus study and psycholinguistic experiments combine into an integrational research programme that aims at an improved understanding and linguistically as well as cognitively adequate modelling of human language performance. Starting from the word order theory articulated by (Hawkins, 1994), we formulate hypotheses on the positional distribution of relative clauses and evaluate them on the basis of data drawn from corpus analyses and acceptability experiments. Our empirical studies confirm the expectation that grammatical weight has a significant effect on relative clause distribution; at the same time, there is an interesting asymmetry between language production and perception data.
Evaluation of biochemical, physiological traits and percentage of essential oil of sickleweed (Falcaria vulgaris) population in different geographical and climatic regions

Sickleweed (Falcaria vulgaris) is the name of a species of annual, and perennial herbaceous plants of the genus Falcaria. Climate change could negatively influnces the performance of various plant species in plant kingdom. In this study, 15 different sickleweed populations from seven provinces of the country were collected based on an unbalanced nest design with 10 replications and the percentage of essential oil, types of chlorophyll, phenol, proline, protein, and carotenoids were measured on them. The results showed that there was a significant difference between populations at the level of one percent for the studied traits. The results of the mean comparison showed that populations Ard-Shaban and Qaz-Ilan in terms of the evaluated traits and especially the percentage of essential oil were at the upper of the studied samples and selected as suitable populations. In addition, populations Gilan-Deylaman and Kur-Gerger-e Sofla were also identified as superior populations in terms of studied traits by cluster analysis and principle component analysis (PCA). Since the high level of proline and biochemical and physiological traits in plants can play a role in plants’ tolerance to stresses, therefore, populations with high values of these traits can be used in stress tolerance breeding programs. Therefore, in this study, populations Gilan-Deylaman and Kur-Gerger-e Sofla can be suitable populations for this purpose. In addition, the essential oil of this plant is used in the treatment of diseases, and therefore populations Ard-Shaban and Qaz-Ilan, which showed a high percentage of essential oil, can be used in breeding programs to increase the performance of this trait.
The Development and Validation of a Psychometric Tool to Assess Behavioral Factors Impacting Personal Dosimeter Use among Medical Radiation Workers

Abstract Personal dosimeters are used by medical radiation workers (MRWs) to monitor their radiation dose from external sources and comply with radiation safety guidelines. Nevertheless, there is evidence of inconsistent use of the devices among MRWs. Behavioral factors influencing the use of personal dosimeters have never been explored. Using established behavioral models, we aimed to develop a psychometric tool to measure the behavioral factors influencing dosimeter use and establish its feasibility, reliability, and validity. A 37-item tool was developed based on a qualitative study and review of the literature. The content relevancy was assessed by six field experts before it was piloted and re-tested on MRWs. The construct validity of the tool was analyzed using exploratory factor analysis to confirm its psychometric properties. Face validation was performed by academicians, field experts, and MRWs to enhance the tool’s readability. The 37 items in the tool belonged to five constructs in the early phase. However, the validation study revealed a reliable 27 item tool with seven constructs, namely: “Attitude,” “Social factors,” “Ability to perform if facilitated,” “Ability to overcome shortcomings,” “Self-efficacy,” “Complexity,” and “Perceived usefulness. ” The item-construct validity index of accepted items was >0.83, and Cronbach’s alpha for each construct ranged between 0.70 to 0.96, while factor loading for each item was between 0.723 to 0.963. All results were considered “good” and “excellent. ” The new tool appears to be valid, reliable, and feasible to measure behavioral factors influencing personal dosimeter use among MRWs, which is helpful to facilitate the planning of interventions to improve behaviors in occupational radiation monitoring.
Structure of an elite co-occurrence network

The rise of social media allowed for rich analyses of their content and their network structure. As traditional media (i.e. newspapers and magazines) are being digitized, similar analyses can be undertaken. This provides a glimpse of the elite, as the news mostly revolves around the more influential members of society. We here focus on a network structure derived from co-occurrences of people in the media. This network has a strong core with peripheral clusters being connected to the core. Nonetheless, these characteristics seem to be mainly a result from the bipartite structure of the data. We employ a simple growing bipartite model that can qualitatively reproduce such a core-periphery structure. Two self-reinforcing processes are vital: (1) more frequently occurring persons are more likely to occur again; and (2) if two people co-occur frequently, they are more likely to co-occur again. This suggests that the core-periphery structure is not necessarily reflective of the elite network in society, but might be an artefact of how they are portrayed in the media.
Serotonin 5-HT7 receptor slows down the Gs protein: a single molecule perspective

The 5-hydroxytryptamine (serotonin) receptor type 7 (5-HT7R) is a G protein–coupled receptor present primarily in the nervous system and gastrointestinal tract, where it regulates mood, cognition, digestion, and vasoconstriction. 5-HT7R has previously been shown to bind to its cognate stimulatory Gs protein in the inactive state. This phenomenon, termed “inverse coupling,” is thought to counteract the atypically high intrinsic activity of 5-HT7R. However, it is not clear how active and inactive 5-HT7 receptors affect the mobility of the Gs protein in the plasma membrane. Here, we used single-molecule imaging of the Gs protein and 5-HT7R to evaluate Gs mobility in the membrane in the presence of 5-HT7R and its mutants. We show that expression of 5-HT7R dramatically reduces the diffusion rate of Gs. Expression of the constitutively active mutant 5-HT7R (L173A) is less effective at slowing Gs diffusion presumably due to the reduced ability to form long-lasting inactive complexes. An inactive 5-HT7R (N380K) mutant slows down Gs to the same extent as the wild-type receptor. We conclude that inactive 5-HT7R profoundly affects Gs mobility, which could lead to Gs redistribution in the plasma membrane and alter its availability to other G protein–coupled receptors and effectors.
Where does it hurt? Small area estimates and inequality in the prevalence of chronic pain

Chronic pain affects up to half of UK adults, impacting quality of life and demand on local health services. Whilst local health planning is currently based on subnational prevalence estimates, associations between pain and sociodemographic characteristics suggest that inequalities in the prevalence of chronic and high‐impact chronic pain between neighbourhoods within local authorities are likely. We aimed to derive lower super output area (LSOA) estimates of the prevalence of chronic and high‐impact chronic pain.
Canada’s Student Mental Health Network: Protocol for a Comprehensive Program Evaluation

Background Prevalence estimates for mental health–related problems, including above-average stress, psychological distress, and symptoms of mental illnesses have increased significantly among Canadian postsecondary students. As demand for downstream mental treatment has surpassed many institutions’ abilities to deliver timely care, there is a need for innovative upstream supports that foster mental health promotion and mental illness prevention among this population. Objective Supported by an extensive network of student volunteers, Canada's Student Mental Health Network is a virtual, one-stop shop for centralized mental health education and evidence-based resources tailored to postsecondary students. This article describes a protocol for the comprehensive evaluation of the Network. Methods Development of the Network was developed using a participatory action research framework. Network content is created and curated by students and reviewed by subject matter experts. The proposed program evaluation will include both a formative process evaluation and a summative impact assessment to determine the feasibility, acceptability, and utility of the Network in addition to assessing change in the 3 primary outcomes of interest: mental health literacy, perceived social support, and help-seeking behavior. Participants will be recruited directly from the Network website using a “rolling” recruitment approach to allow for continuous data collection and evaluation. A combination of qualitative (ie, interviews) and quantitative (ie, surveys) methods of data collection will be used. Results The process of evaluation of the Network will begin in September 2022, collecting data for 1 year. In September 2023, the impact evaluation will begin using the same follow-up schedule. Data collection will then remain ongoing to facilitate the continued evaluation of the Network. Reports detailing evaluation data will be released annually. Conclusions The Network is a novel and innovative method of delivering universal mental health promotion to Canadian postsecondary students by providing centralized and freely accessible mental health education and resources, created by students and validated by subject matter experts. The continued creation and curation of resources for the Network will be ongoing to meet the evolving needs of the target population. International Registered Report Identifier (IRRID) PRR1-10.2196/41521
ELF3 suppresses gallbladder cancer development through downregulation of the EREG/EGFR/mTOR complex 1 signalling pathway

The prognosis of gallbladder cancer (GBC) remains poor, and a better understanding of GBC molecular mechanisms is important. Genome sequencing of human GBC has demonstrated that loss‐of‐function mutations of E74‐like ETS transcription factor 3 (ELF3) are frequently observed, with ELF3 considered to be a tumour suppressor in GBC. To clarify the underlying molecular mechanisms by which ELF3 suppresses GBC development, we performed in vivo analysis using a combination of autochthonous and allograft mouse models. We first evaluated the clinical significance of ELF3 expression in human GBC tissues and found that low ELF3 expression was associated with advanced clinical stage and deep tumour invasion. For in vivo analysis, we generated Pdx1‐Cre; KrasG12D; Trp53R172H; Elf3f/f (KPCE) mice and Pdx1‐Cre; KrasG12D; Trp53R172H; Elf3wt/wt (KPC) mice as a control and analysed their gallbladders histologically. KPCE mice developed larger papillary lesions in the gallbladder than those developed by KPC mice. Organoids established from the gallbladders of KPCE and KPC mice were analysed in vitro. RNA sequencing showed upregulated expression of epiregulin (Ereg) in KPCE organoids, and western blotting revealed that EGFR/mechanical targets of rapamycin complex 1 (mTORC1) were upregulated in KPCE organoids. In addition, ChIP assays on Elf3‐overexpressing KPCE organoids showed that ELF3 directly regulated Ereg. Ereg deletion in KPCE organoids (using CRISPR/Cas9) induced EGFR/mTORC1 downregulation, indicating that ELF3 controlled EGFR/mTORC1 activity through regulation of Ereg expression. We also generated allograft mouse models using KPCE and KPC organoids and found that KPCE organoid allograft tumours exhibited poorly differentiated structures with mTORC1 upregulation and mesenchymal phenotype, which were suppressed by Ereg deletion. Furthermore, EGFR/mTORC1 inhibition suppressed cell proliferation and epithelial–mesenchymal transition in KPCE organoids. Our results suggest that ELF3 suppresses GBC development via downregulation of EREG/EGFR/mTORC1 signalling. EGFR/mTORC1 inhibition is a potential therapeutic option for GBC with ELF3 mutation. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Adding Safety Rules to Surgeon-Authored Virtual Reality Training

Introduction The Toolkit for Illustration of Procedures in Surgery (TIPS) is an open source virtual reality (VR) laparoscopic simulation-based training environment with force feedback. The TIPS-author is a content creation interface that allows a surgeon educator (SE) to assemble new laparoscopic training modules. New technology enables safety rules to be specified by the SE, automatically tracks specified safety errors, and summarizes and communicates achievements and errors to the surgical trainee. Methods The TIPS-author combines and initializes building blocks of anatomy with their physical properties, as selected by the SE from a database. The SE can add any safety rule that can be tested in terms of location, proximity, separation, clip count, and force. Errors are then automatically monitored during simulation and recorded as visual snapshots for feedback to the trainee. The TIPS was field tested at 2 surgical conferences, one before and one after adding the error snapshot feature. Results Sixty-four respondents at 2 surgical conferences assessed the utility of TIPS on a Likert scale. While other ratings remained unchanged for an overall score of 5.24 of 7 (7 = very useful), the rating of the statement “The TIPS interface helps learners understand the force necessary to explore the anatomy” improved from 5.04 to 5.35 of 7 after the snapshot mechanism was added. Conclusions The ratings indicate the viability of the TIPS open source SE-authored surgical training units with safety rules. Presenting SE-determined procedural missteps via the snapshot mechanism at the end of the training increases perceived utility.
Space-Based Photometry of Eclipsing Binaries

Abstract I briefly review the history and prospects for the study of eclipsing binary star systems from space-based observatories. The benefits of shifting to space satellites lie in the high precision and cadence achievable, as well as the ability to access wavelength regions which are unattainable from the ground. Whilst small amounts of data on eclipsing binaries were obtained by the Voyager, IUE, OAO-II, Hipparcos and MOST, the more recent CoRoT and Kepler missions were the first to provide extensive data on large numbers of systems. The future holds the prospect of the PLATO satellite, which will go bigger, better and brighter.
Acupuncture for gait disturbance of patients with subacute and chronic stroke: a systematic review and meta-analysis protocol

Introduction Hemiparetic gait is one of the most common sequelae of a stroke. Acupuncture has shown potential in correcting hemiplegic gait patterns and improving motor function recovery after stroke. However, controversial findings and a lack of supportive evidence on the effectiveness of acupuncture for post-stroke hemiplegia. The intelligent gait analysis system provides a new perspective for the study of hemiparetic gait. This systematic review aims to collect relevant studies and critically evaluate the efficacy and safety of acupuncture in alleviating gait disturbance of post-stroke hemiplegia based on quantified gait parameters. Methods and analysis A comprehensive search of PubMed, Embase, Cochrane stroke group trials register, Cochrane Central Register of Controlled Trials, CINAHL, AMED, three Chinese databases (Chinese Biomedical Literatures database (CBM), National Knowledge Infrastructure (CNKI), and Wan fang Digital Periodicals), four trails registries (The WHO International Clinical Trials Registry Platform, The Chinese Clinical Trial Registry, The US National Institutes of Health Ongoing Trials Register, and The Australian New Zealand Clinical Trials Registry) will be conducted to identify randomised controlled trials of acupuncture for gait disturbance in post-stroke patients. No restrictions on language or publication status. The primary outcomes are gait temporospatial parameters (eg, step length, stride length, step width, step frequency (cadence), walking speed, etc), and gait kinematic parameters (eg, hip peak flex/extend angle, knee peak flex/extend angle, ankle peak dorsi/plantar-flexion angle, etc). We will assess bias using the approach recommended by the Cochrane Handbook for Systematic Reviews of Interventions. A meta-analysis will be conducted to synthesise the evidence for each outcome measure. The χ2 test and I2 statistic will be used for assessing heterogeneity between studies. Ethics and dissemination No ethical approval is needed because no primary data is collected. Scientific conferences or peer-reviewed journals will publish the findings. PROSPERO registration number CRD42022384348.
Binary complexes and algebraic K-theory

FACULTY OF HUMAN AND SOCIAL SCIENCES SCHOOL OF MATHEMATICAL SCIENCES Doctor of Philosophy Binary complexes and algebraic K-theory by Thomas K. Harris Grayson has recently produced a purely algebraic description of the higher algebraic Kgroups of an exact category. We take Grayson’s presentation as the definition of the K-groups and examine the strength of the resulting theory. We provide the relevant background to state Grayson’s theorem, and make a comparison between Grayson’s presentation for K1 and that of Nenashev. We give new algebraic proofs of the additivity, resolution, and cofinality theorems of algebraic K-theory. Finally we construct exterior power operations on the higher K-groups of schemes using Dold–Puppe complexes. We prove that these operations are homomorphisms on Kn for n > 0, and that they satisfy the second axiom of a λ-ring.
Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static–Cidal Screening of Analogues

While treatment options for human African trypanosomiasis (HAT) have improved significantly, there is still a need for new drugs with eradication now a realistic possibility. Here, we report the development of 2,4-diaminothiazoles that demonstrate significant potency against Trypanosoma brucei, the causative agent of HAT. Using phenotypic screening to guide structure–activity relationships, potent drug-like inhibitors were developed. Proof of concept was established in an animal model of the hemolymphatic stage of HAT. To treat the meningoencephalitic stage of infection, compounds were optimized for pharmacokinetic properties, including blood–brain barrier penetration. However, in vivo efficacy was not achieved, in part due to compounds evolving from a cytocidal to a cytostatic mechanism of action. Subsequent studies identified a nonessential kinase involved in the inositol biosynthesis pathway as the molecular target of these cytostatic compounds. These studies highlight the need for cytocidal drugs for the treatment of HAT and the importance of static–cidal screening of analogues.
The Edinburgh–Durham Southern Galaxy Catalogue – III. w(θ) from the full survey

Despite many independent estimates, there has been little consensus reached as to the form of the two-point angular correlation function of galaxies. The two-point angular correlation function for the recently completed Edinburgh-Durham Southern Galaxy Catalogue. This galaxy survey consists of digitized COSMOS scans for 60 UK Schmid fields centred at the South Galactic Pole. The w(θ) results from the catalogue are presented at four depths: b j = 17.5, 18.5, 19.5 and 20.3
A Study of Fitting the Generalized Lambda Distribution to Solar Radiation Data.

Abstract The increased interest in the climatology of solar radiation dictates a need for a distribution to fit daily solar radiation totals which tend to have negatively-skewed probability distributions. Even daily mean solar radiation for weekly periods tends to have non-normal distributions. The generalized lambda distribution, which includes a wide variety of curve shapes, is discussed for fitting these data. The underlying probability distribution is a generalization of the lambda distribution from three to four parameters. Using the weekly averages of daily solar radiation totals for each of 12 weeks during the growing season and daily totals for the week 5-11 July at West Lafayette, Indiana, it is shown that the generalized lambda distribution model fits the data well. Some results concerning percentiles and quantiles, parameter estimates, and goodness-of-fit tests are also discussed.
Eating disorder symptoms among transgender and gender diverse youth

Compared to cisgender peers, transgender and gender diverse (TGD) youth and adults report elevated eating disorder (ED) symptoms likely related to gender dysphoria and attempts to modify their bodies accordingly. Less is known about the impact on gender-affirming care and ED symptoms. This study aimed to expand on extant research and describe ED symptoms in TGD youth seeking gender-affirming care while exploring potential associations between gender-affirming hormone use and ED symptoms. A total of 251 TGD youth completed the Eating Disorders Examination-Questionnaire (EDE-Q) as part of routine clinical care. ANCOVAs and negative binomial regressions examined differences in ED symptoms among transgender females (identifying as female but assigned male at birth) and transgender males (identifying as male but assigned female at birth). ED severity was not significantly different among transgender females versus transgender males, (p = .09), or associated with gender-affirming hormone use (p = .07). Transgender females receiving gender-affirming hormones reported a greater proportion of objective binge eating episodes compared to those who were not (p = .03). Over a quarter of TGD youth reported engagement in ED behaviors suggesting assessment and intervention related to ED behaviors among TGD youth is imperative since adolescence is a particularly vulnerable period for adolescents and engagement in ED behaviors could lead to full ED development and medical risk.
A quantitative model to ensure capacity sufficient for timely access to care in a remote patient monitoring program

Algorithm‐enabled remote patient monitoring (RPM) programs pose novel operational challenges. For clinics developing and deploying such programs, no standardized model is available to ensure capacity sufficient for timely access to care. We developed a flexible model and interactive dashboard of capacity planning for whole‐population RPM‐based care for T1D.
The influence of different sub-bandage pressure values in the prevention of recurrence of venous ulceration—A ten year follow-up

Objective The aim of this study was to establish the efficacy of three different strengths of compression systems in the prevention of venous leg ulcer (VLU) recurrences during a 10-year follow up period. Methods An open, prospective, randomized, single-center study included 477 patients (240 men, 237 women; mean age 59 years). Patients were randomized into three groups: Group A) 149 patients (allocated to wear elastic stocking 18–25 mmHg). Group B) 167 patients (wearing compression device exerting 25–35 mmHg), and Group C) 161 patients (treated with multilayer compression system exerting 35–50 mmHg). Results Overall, 65% (234/360) of patients had recurrent VLU within 10 years. Recurrence occurred in 120 (96%) of 125 in group A, in 89 (66.9%) of 133 patients in group B and in 25 (24.5%) of 102 patients in group C (p < 0.05) Conclusion Compression systems with the higher compression class provide lower recurrence rate.