Miracle-dz/UniFAR-FTUs huggingface dataset:
Restoration of Motor Function through Delayed Intraspinal Delivery of Human IL-10-Encoding Nucleoside-Modified mRNA after Spinal Cord Injury

Efficient in vivo delivery of anti-inflammatory proteins to modulate the microenvironment of an injured spinal cord and promote neuroprotection and functional recovery is a great challenge. Nucleoside-modified messenger RNA (mRNA) has become a promising new modality that can be utilized for the safe and efficient delivery of therapeutic proteins. Here, we used lipid nanoparticle (LNP)-encapsulated human interleukin-10 (hIL-10)-encoding nucleoside-modified mRNA to induce neuroprotection and functional recovery following rat spinal cord contusion injury. Intralesional administration of hIL-10 mRNA-LNP to rats led to a remarkable reduction of the microglia/macrophage reaction in the injured spinal segment and induced significant functional recovery compared to controls. Furthermore, hIL-10 mRNA treatment induced increased expression in tissue inhibitor of matrix metalloproteinase 1 and ciliary neurotrophic factor levels in the affected spinal segment indicating a time-delayed secondary effect of IL-10 5 d after injection. Our results suggest that treatment with nucleoside-modified mRNAs encoding neuroprotective factors is an effective strategy for spinal cord injury repair.
Bistatic scattering and identification of the resonances of elastic spheroids

Resonances appear in the backscattering cross section of elastic objects (interfering with the contribution of specular echoes) when observed as a function of frequency. Only the resonance frequencies and resonance widths can be determined from such an observation, but not the resonance order. For targets of separable geometry, it has been shown both experimentally [G. Maze and J. Ripoche, J. Acoust. Soc. Am. 73, 41 (1983)] and theoretically [M. F. Werby and H. Uberall, J. Acoust. Soc. Am. 82, 265 (1987)] that bistatic observations can determine the resonance order after subtraction of the specular background. The method is applied here to bistatic scattering from elastic spheroids, as analyzed by a T‐matrix formalism and computer code. Mode mixing takes place now, but it is shown that for moderate aspect ratios (up to 3:1) a dominant mode can still be used to characterize the resonances.
An automatic registration algorithm of infrared and visible images based on hybrid image features

In this paper, a new method is presented to match a pair of visible and infrared images of same scene based on hybrid visual features including line segments and interest points. First, improved Harris corner extraction method and line segment detector method is used to extract feature points and segments. Then, a novel descriptor integrating the information of line segments and interest points is proposed. Finally, the nearest neighbor algorithm is utilized to match the descriptors, and the RANSAC(Random Sample Consensus) algorithm is employed to rule out the wrong match pairs. The performances are evaluated by extensive experiments on real images. The results show that the proposed algorithm can take advantage of similar structures between the multimodal images to realize automatic matching efficiently.
Improvements in Quantitative Precipitation Forecasts with the Eta Regional Model at the National Centers for Environmental Prediction: The 48-km Upgrade

Since 9 June 1993, the eta coordinate regional model has been run twice daily at the National Centers for Environmental Prediction (NCEP, previously the National Meteorological Center) as the NCEP's “early” operational model. Its performance is regularly monitored in a variety of ways, with particular attention given to precipitation forecasts. Throughout this period, the eta model has demonstrated significantly increased accuracy in forecasting daily precipitation amounts compared to NCEP's Nested Grid Model (NGM). The model has shown a smaller but equally consistent advantage in skill against that of NCEP's global spectral model. Precipitation scores of these three operational models for the 6-month period March–August 1995 are presented. This interval is chosen because the 6-month-long periods September–February and March–August have been used in previous model comparisons and because an upgraded version of the eta model, run at 48-km resolution, was also regularly executed twice daily during the March.
Multichannel DC SQUID sensor array for biomagnetic applications

A biomagnetic multichannel system for medical diagnosis of the brain and heart has been developed. 37 axial first order gradiometers (manufactured as flexible superconducting printed circuits) are arranged in a circular flat array of 19 cm in diameter. Additionally, three orthogonal magnetometers are provided. The DC SQUIDs are fabricated in all-Nb technology, ten on a chip. The sensor system is operated in a shielded room with two layers of soft magnetic material and one layer of Al. The everyday noise level is 10 fT/Hz/sup 1/2/ at frequencies above 10 Hz. Within two years of operation in a normal urban surrounding, useful clinical applications have been demonstrated (e.g., for epilepsy and heart arrhythmias). For the first time current sources of sporadic events causing epilepsy or ventricular extrasystoles have been localized from coherent recordings of complete biomagnetic field distributions with spatial resolution of millimeters and temporal resolution of 1 ms.
Comparison of static and light-induced thermal hystereses of a spin-crossover solid, in a mean-field approach†

We investigate the relationship between the two mean-field models which have been proposed independently for characterizing the static and the light-induced thermal hystereses of spin-transition solids, respectively involving an interaction parameter J and a relaxation self-acceleration parameter α. We unify these two models into a unique - static and dynamic - mean-field description based on Arrhenius thermal activation processes. The model is used to analyse the experimental hysteresis loops, the relaxation curves in the dark, and the light-induced instability in the spin-crossover system [FexCo1-x(btr)2(NCS)2]H2O. A linear relationship between J and αT is obtained, which is in qualitative agreement with the available theories.
Accurate geometrical restraints for Watson–Crick base pairs

Revised geometrical parameters are proposed for the Watson–Crick pairs of nucleobases, for use as restraints in modeling and refinement of the structures of nucleic acids. Accurate values of these parameters were derived (and compared) from small-molecule Cambridge Structural Database structures, from super accurate ultrahigh-resolution nucleic acid structures in the Protein Data Bank, and from quantum mechanical calculations. The effect of base pairing on the molecular geometry of the nucleobases is also investigated.
System for tracking transplanted limbal epithelial stem cells in the treatment of corneal stem cell deficiency

The prevailing hypothesis for the existence and healing of the avascular corneal epithelium is that this layer of cells is continually produced by stem cells in the limbus and transported onto the cornea to mature into corneal epithelium. Limbal Stem Cell Deficiency (LSCD), in which the stem cell population is depleted, can lead to blindness. LSCD can be caused by chemical and thermal burns to the eye. A popular treatment, especially in emerging economies such as India, is the transplantation of limbal stem cells onto damaged limbus with hope of repopulating the region. Hence regenerating the corneal epithelium. In order to gain insights into the success rates of this treatment, new imaging technologies are needed in order to track the transplanted cells. Optical Coherence Tomography (OCT) is well known for its high resolution in vivo images of the retina. A custom OCT system has been built to image the corneal surface, to investigate the fate of transplanted limbal stem cells. We evaluate two methods to label and track transplanted cells: melanin labelling and magneto-labelling. To evaluate melanin labelling, stem cells are loaded with melanin and then transplanted onto a rabbit cornea denuded of its epithelium. The melanin displays strongly enhanced backscatter relative to normal cells. To evaluate magneto-labelling the stem cells are loaded with magnetic nanoparticles (20-30nm in size) and then imaged with a custom-built, magneto-motive OCT system.
Partition Placement and Resource Allocation for Multiple DNN-Based Applications in Heterogeneous IoT Environments

The evolution of the Internet of Things (IoT) has been driving the explosive growth of deep neural network (DNN)-based applications and processing demands. Hence, edge computing has emerged as a potential solution to meet these processing requirements. However, emerging IoT applications have increasingly demanded to run multiple DNNs to extract multifaceted knowledge, requiring more computational resources and increasing response time. Consequently, edge nodes cannot act as a complete substitute for the previous cloud paradigm, owing to their relatively limited resources. To address this problem, we propose to incorporate nearby IoT devices when allocating resources to multiple DNN models. Furthermore, the optimization of resource allocation can be hindered by the heterogeneity of IoT devices, which affects the delay performance of DNN-based computing. In this context, we propose a DNN partition placement and resource allocation strategy that considers different processing powers, memory, and battery levels for heterogeneous IoT devices. We evaluate the performance of the proposed strategy through extensive simulations. Simulation results reveal that the proposed strategy outperforms other existing solutions in terms of end-to-end delay, service probability, and energy consumption. The proposed solution was further simulated in a Kubernetes testbed consisting of actual devices to assess its feasibility.
cw three-wave mixing in single-mode optical fibers

Strong continuous three‐wave mixing of 514.5‐nm argon laser light in a single‐mode fiber is reported. The effect, due to the third‐order nonlinearity of silica, has been observed for light whose frequency spectrum consists of either a few discrete monochromatic frequency components separated by ∼1 GHz or a quasicontinuous distribution of frequencies having a spectral envelope ∼4 GHz wide. We show that the effect provides a simple and effective method for measuring the nonlinearity of silica. In the first manifestation of the effect, the nonlinearity mixes the frequency components to produce new frequencies. In the second, multiple mixing occurs that broadens the quasicontinuous spectrum. This manifestation of the effect is large; broadening by a factor of 4 has been observed with lower intensity levels than are required to produce stimulated Brillouin scattering in the same fiber. A theoretical model is presented to describe spectral broadening by three‐wave mixing for the case of small broadening. The ef.
Age Influences on Lifestyle and Stress Perception in the Working Population

Workplace health promotion programs and services offered by insurers may play a fundamental role to foster health/well-being and to prevent chronic diseases. To this end, they should be tailored to companies/employees’ requirements and characteristics. In particular, age needs to be taken into account, considering both that young age workers are generally healthy, and that young age is the best period in lifespan to address prevention and instilling healthy behaviors. We employed an anonymous, simple web-based questionnaire (filled out by 1305 employees) which furnishes data regarding lifestyle (nutrition, exercise, smoking, stress, sleep, etc.), some of which were used to build a unique descriptor (Lifestyle Index; 0–100 higher scores being healthier). We considered three subgroups accordingly to age: ≤30; between 30 and 50; >50 years. This study showed age influences lifestyle and stress perception in the working population: the youngest employees (both men and women) presented the worst lifestyle index, particularly in its stress component. This observation may potentially be useful to tailor workplace health promotion programs and to personalize insurance protocols and services offered to employees. The practical message of our study is that in healthy young people focusing only on medical parameters (frequently within normal ranges in this cohort), albeit important, may be not sufficient to foster proactive actions to prevent chronic non-communicable diseases in adult life. Vice versa, driving their attention on current behaviors might elicit their proactive role to improve lifestyle, getting immediate advantages such as well-being improvement and the possibility to best manage stress.
Synthesis of Multifunctional Eu(III) Complex Doped Fe3O4/Au Nanocomposite for Dual Photo-Magnetic Hyperthermia and Fluorescence Bioimaging

In this paper, the luminescent complex Eu(3-thenoyltrifluoroacetonate)3 was integrated with Fe3O4 and gold (Au) nanoparticles to form a multifunctional nanocomposite, Fe3O4/Au/Eu(TTA)3 (FOASET NC), for dual magnetic-photothermal therapy and biomedical imaging. Upon functionalization with amine-NH2, the FOASET NC exhibits a small size of 60–70 nm and strong, sharp emission at λmax = 614 nm, enhanced by surface plasmon resonance (SPR) of Au nanoparticles that provided an effective label for HT29 colorectal cancer cells by fluorescence microscopy imaging. In addition, a hyperthermia temperature (42–46 °C) was completely achieved by using these FOASET NCs in an aqueous solution with three heating modes for (i) Magnetic therapy (MT), (ii) Photothermal therapy (PT), and (iii) Dual magnetic-photothermal therapy (MPT). The heating efficiency was improved in the dual magnetic-photothermal heating mode.
Total energy from the many-body perturbation approach with a model spectral function: An application to simple metals

We present an application of the ab initio many-body perturbation approach for structural properties of solids. The total energy is calculated from the Galitskii-Migdal formula with a model spectral function whose parameters are determined from the GW method. The scheme is applied to calculate the equilibrium lattice constant and bulk modulus of sodium and aluminum, with good agreement with experiments.
Exchange Monte Carlo Dynamics in the SK Model

The equilibration process of the Sherrington–Kirkpatrick spin-glass model is investigated using the exchange Monte Carlo (MC) method. It is found that a MC time scale for equilibration, τ eq , is nearly proportional to the system size and weakly depends on temperature, in contrast to the thermal activation behavior observed in a conventional MC simulation. Fluctuation of the overlap distribution over samples is confirmed to follow the non trivial probability law predicted by the replica-symmetry-breaking theory.
Calculation of proximity losses in multistranded conductor bunches

Proximity losses appear in multistranded conductors carrying time-varying currents, because each strand is affected by the collective transverse magnetic field of all the other strands. The total proximity loss increases as the square of the number of strands, and, even for small numbers, exceeds that due to skin effect. Total proximity loss is greatest in bunches having circular envelope sections. In bunches having other sections, the losses are reduced, relative to a circular bunch with the same number of strands, by a margin that increases as the bunch shape departs from the circle. < >
A unified jackknife theory for empirical best prediction with M-estimation

The paper presents a unified jackknife theory for a fairly general class of mixed models which includes some of the widely used mixed linear models and generalized linear mixed models as special cases. The paper develops jackknife theory for the important, but so far neglected, prediction problem for the general mixed model. For estimation of fixed parameters, a jackknife method is considered for a general class of M-estimators which includes the maximum likelihood, residual maximum likelihood and ANOVA estimators for mixed linear models and the recently developed method of simulated moments estimators for generalized linear mixed models. For both the prediction and estimation problems, a jackknife method is used to obtain estimators of the mean squared errors (MSE). Asymptotic unbiasedness of the MSE estimators is shown to hold essentially under certain moment conditions. Simulation studies undertaken support our theoretical results. 1. Introduction. Due to the advent of high-speed computers and powerful software, computer-oriented statistical methods, including various resampling methods, have received considerable attention in recent years as statisticians are constantly facing complex problems. The jackknife method is one such simple resampling method which is very popular among survey samplers, primarily due
Physical and Recreational Activities, Sedentary Screen Time, Time Spent with Parents and Drug Use in Adolescents

In a context in which sedentary screen time is on the rise and adolescents are less eager to engage in free-time activities, physical and recreational activities, although too often ignored, have proven to be an antidote for a large array of psychological and behavioral problems in adolescents, including drug use. The present study is a cross-sectional investigation of the association between physical and recreational activities, sedentary screen time, and time spent with parents and the intensity of drug use in adolescents. The participants were part of a representative sample of 2677 adolescents from Bucharest, Romania. The results indicate that vigorous physical and recreational activities, as well as time spent with parents, were negatively associated with an index of drug use (13 drugs), while screen time positively predicted the intensity of drug use. These findings raise the question of the involvement of parents and educational authorities in promoting healthy behaviors and good practices for the prevention of drug use and improving public adolescents’ health.
Impurity-induced resistivity of ferroelastic domain walls in doped lead phosphate

The topology and the trace of ferroelastic domains, namely W walls, of Ca-doped lead orthophosphate (Pb1−x, Cax)3 (PO4)2 with a Ca content of 2.7% mol were studied on the monoclinic cleavage plane (100) using contact mode atomic force microscopy. Furthermore, conducting atomic force microscopy was applied using a bias voltage across the cantilever and the sample inducing a tunnelling current. As a reference a pure lead phosphate crystal was used. Only the Ca-doped lead phosphate crystals showed a considerable difference in conductivity between walls and the bulk. The conductivity in the bulk was found to be approximately 7% higher than in the domain walls. The experimental results show that ferroelastic domain walls of atomistic width can work as barriers to dielectric transport.
Nutritional quality and in vitro digestibility of fermented rice bran based on different types and doses of inoculants

Objective: The study was conducted to determine the effect of inoculants of different types and doses on the nutrient quality and in vitro digestibility of fermented rice bran. Materials and Methods: The study was designed using a completely randomized design with a 3 × 3-factorial pattern. The first factor was the type of inoculum, consisting of Saccharomyces cerevisiae (SC), Effective Microorganism-4, and Saus Burger Pakan (SBP). The second factor is inoculum doses, which are as follows: levels 2%, 4%, and 6%. The variables measured included chemical composition, fiber fraction content, dry matter digestibility and organic matter digestibility. Results: The results showed that the type of inoculation treatment and the doses of inoculation did not affect the dry matter (DM) content of fermented bran, and the organic matter content of fermented bran was only affected by the inoculation dose factor (p < 0.05). The highest crude protein and Extract Ether (EE) were obtained in the SBP inoculants, which increased linearly with increasing inoculation doses (p < 0.05). While a significant decrease (p < 0.05) occurred in crude fiber content. The cellulose, hemicellulose, lignin, acid detergent fiber (ADF), and neutral detergent fiber (NDF) fractions were significantly lower in the SBP treatment as the dose increased. The SBP inoculant type produced the highest DMD (p < 0.05) but showed a response that was not different from the SC inoculant treatment for OMD. Increasing inoculation doses of 2%, 4%, and 6% linearly increased the DMD and OMD of fermented bran (p < 0.05). Overall, inoculant application on fermented bran showed an interaction effect except for the components of DM, EE, ADF, NDF, and DMD of fermented bran. Conclusions: It was concluded that the SBP at 6% and their combination resulted in the best chemical quality and digestibility of rice bran.
Phase-Field Simulation of Temperature-Dependent Thermal Shock Fracture of Al2O3/ZrO2 Multilayer Ceramics with Phase Transition Residual Stress

Compared with single-phase ceramics, the thermal shock crack propagation mechanism of multiphase layered ceramics is more complex. There is no experimental method and theoretical framework that can fully reveal the thermal shock damage mechanism of ceramic materials. Therefore, a multiphase phase-field fracture model including the temperature dependence of material for thermal shock-induced fracture of multilayer ceramics is established. In this study, the effects of residual stress on the crack propagation of ATZ (Al2O3-5%tZrO2)/AMZ (Al2O3-30%mZrO2) layered ceramics with different layer thickness ratios, layers, and initial temperatures under bending and thermal shock were investigated. Simulation results of the fracture phase field under four-point bending are in good agreement with the experimental results, and the crack propagation shows a step shape, which verifies the effectiveness of the proposed method. With constant thickness, high-strength compressive stress positively changes with the layer thickness ratio, which contributes to crack deflection. The cracks of the ceramic material under thermal shock have hierarchy and regularity. When the layer thickness ratio is constant, the compressive residual stress decreases with the increase in the layer number, and the degree of thermal shock crack deflection decreases.
Study of Round Bodies: Conceptions and Praxis of a Didactic Sequence in Light of Guy Brousseau’s Theory

Background: Guy Brousseau’s theory of didactic situations has been considered an apparatus for the methodological structuring of didactic sequences configured in didactic and adidactic situations. Objectives: To investigate the contributions of the theory of didactic situations to the study of round bodies, focused on a praxis that meaningfully consolidates knowledge for the students. Design: We propose solving problem situations concerning the calculus of surface areas and volumes of round bodies using Cavalieri’s principle and Pappus’s theorems. Setting and participants: The research was conducted with two high school third-grade classes of a state institute of education located in the municipality of Júlio de Castilhos, RS, Brazil, with the participation of 25 students. Data collection and analysis: It was carried out through activities developed in the classroom and feedback given through Google Classroom. It was subsidised by the documental transcription of students’ records. Results: The research indicated that the didactic sequence development favoured intellectual autonomy and meaningful learning about the object of knowledge. Conclusions: The theory of didactic situations provided important subsidies for didactic organisation and analysis of the knowledge consolidation process involving the study of round bodies, indicating its application in the study of other mathematical objects in high school and higher education.