Miracle-dz/UniFAR-FTUs huggingface dataset:
Predictive washout filter design for VR-based motion simulator

Modern simulators normally consist of hydraulic motion platform, computer visual systems, force feedback systems, and sound systems such that the operator is provided realistic motion cues given the state of the vehicle. Owing to the limited motion workspace of typical motion platform, filtering is required between the computer vehicle motion and the desired simulator motion trajectory. These filters are commonly referred to as washout filter. Unlike most of the washout algorithms, which focus on how to tune the filter parameters wisely or flexibly, this paper proposes a method, which can directly manages the simulator trajectory by moving it freely in the workspace without the sensation of operator. By this approach, simulation results show a smaller workspace required under the same filter parameters. In other words, more aggressive filter parameters can be chosen under the same constraint of limited workspace, which indirectly implies that a more realistic simulator performance can be attained.
DAnCER: Disease-Annotated Chromatin Epigenetics Resource

Chromatin modification (CM) is a set of epigenetic processes that govern many aspects of DNA replication, transcription and repair. CM is carried out by groups of physically interacting proteins, and their disruption has been linked to a number of complex human diseases. CM remains largely unexplored, however, especially in higher eukaryotes such as human. Here we present the DAnCER resource, which integrates information on genes with CM function from five model organisms, including human. Currently integrated are gene functional annotations, Pfam domain architecture, protein interaction networks and associated human diseases. Additional supporting evidence includes orthology relationships across organisms, membership in protein complexes, and information on protein 3D structure. These data are available for 962 experimentally confirmed and manually curated CM genes and for over 5000 genes with predicted CM function on the basis of orthology and domain composition. DAnCER allows visual explorations of the integrated data and flexible query capabilities using a variety of data filters. In particular, disease information and functional annotations are mapped onto the protein interaction networks, enabling the user to formulate new hypotheses on the function and disease associations of a given gene based on those of its interaction partners. DAnCER is freely available at http://wodaklab.org/dancer/.
Music Information Technology and Professional Stakeholder Audiences: Mind the Adoption Gap

The academic discipline focusing on the processing and organization of digital music information, commonly known as Music Information Retrieval (MIR), has multidisciplinary roots and interests. Thus, MIR technologies have the potential to have impact across disciplinary boundaries and to enhance the handling of music information in many different user communities. However, in practice, many MIR research agenda items appear to have a hard time leaving the lab in order to be widely adopted by their intended audiences. On one hand, this is because the MIR field still is relatively young, and technologies therefore need to mature. On the other hand, there may be deeper, more fundamental challenges with regard to the user audience. In this contribution, we discuss MIR technology adoption issues that were experienced with professional music stakeholders in audio mixing, performance, musicology and sales industry. Many of these stakeholders have mindsets and priorities that differ considerably from those of most MIR academics, influencing their reception of new MIR technology. We mention the major observed differences and their backgrounds, and argue that these are essential to be taken into account to allow for truly successful cross-disciplinary collaboration and technology adoption in MIR.
Comparison of Vibrio parahaemolyticus cultures isolated in the United States with those isolated in Japan.

Biologic, biochemical, and serologic characteristics of 79 halophilic vibrios isolated in the United States were studied and compared with 100 isolates of Vibrio parahaemolyticus obtained from patients with gastroenteritis. Sixty-three of the isolates were identified as V. parahaemolyticus. Eleven of these had combinations of O and K antigens that were previously unreported. They were 01:K5, 01:K33, 01:K37, 01:K44, 03:K25, 04:K37, 05:K3, and 07:K39. Whether or not this represents a true geographic variation in the sertotypes of this bacterium is unknown. The remaining 16 isolates studied were not V. parahaemolyticus. Six were Vibrio alginolyticus, and 10 were related marine vibrios. In Japan, Vibrio parahaemolyticus, an enteropathogenic, facultatively halophilic bacterium, is of major importance as an etiologic agent of gastroenteritis. Recently, documented cases of gastroenteritis caused by this microorganism have also been reported in the United States [1]. The majority of isolations of this bacterium, however, have been from marine products, sea water, and localized tissue infections of individuals in recreational contact with the marine environment [27]. Seventy-nine isolates, previously identified as V. parahaemolyticus or as V. parahaemolyticuslike, were obtained from investigators in the United States. These were compared with 100 cultures of V. parahaemolyticus isolated from patients in Japan. Data obtained from this comparative study are presented.
Bihamiltonian Equations on Polynomial Virasoro

The key point in this unified description is that one of the two Poisson structures is the same for all the three equations and it is provided by the linear canonical Lie–Poisson bracket. While the other Poisson structure is constant and obtained by “freezing” the Lie–Poisson structure in a different point for each equation. Moreover all three equations are Euler equations with respect to three different Hamiltonians.
Arbitration (or How to Merge Knowledge Bases)

Knowledge-based systems must be able to "intelligently" manage a large amount of information coming from different sources and at different moments in time. Intelligent systems must be able to cope with a changing world by adopting a "principled" strategy. Many formalisms have been put forward in the artificial intelligence (AI) and database (DB) literature to address this problem. Among them, belief revision is one of the most successful frameworks to deal with dynamically changing worlds. Formal properties of belief revision have been investigated by Alchourron, Gardenfors, and Makinson, who put forward a set of postulates stating the properties that a belief revision operator should satisfy. Among these properties, a basic assumption of revision is that the new piece of information is totally reliable and, therefore, must be in the revised knowledge base. Different principles must be applied when there are two different sources of information and each one has a different view of the situation-the two views contradicting each other. If we do not have any reason to consider any of the sources completely unreliable, the best we can do is to "merge" the two views in a new and consistent one, trying to preserve as much information as possible. We call this merging process arbitration. In this paper, we investigate the properties that any arbitration operator should satisfy. In the style of Alchourron, Gardenfors, and Makinson we propose a set of postulates, analyze their properties, and propose actual operators for arbitration.
Cell Tracking using Coupled Active Surfaces for Nuclei and Membranes

An Insight Toolkit (ITK) processing framework for segmenting and tracking nuclei in time-lapse microscopy images using coupled active contours is presented in this paper. We implement the method of Dufour et al.[2] to segment and track cells in fluorescence microscopy images. The basic idea is to model the image as a constant intensity background with constant intensity foreground components. We utilizes our earlier submissions on the Chan and Vese algorithm [1] and its multiphase extension [5] to build our new tracking filter. The tracking filter itk::MultiphaseLevelSetTracking inputs a segmentation result (or a coarse estimate) from the previous time-point along with the feature image and generates a new segmentation output. By iteratively repeating this process across all time-points, real-time tracking is made possible. We include 2D/3D example code, parameter settings and show the results generated on a 2D zebrafish embryo image series.
The Silica Balance in the World Ocean: A Reestimate

The net inputs of silicic acid (dissolved silica) to the world ocean have been revised to 6.1 � 2.0 teramoles of silicon per year (1 teramole = 1012 moles). The major contribution (about 80 percent) comes from rivers, whose world average silicic acid concentration is 150 micromolar. These inputs are reasonably balanced by the net ouputs of biogenic silica of 7.1 � 1.8 teramoles of silicon per year in modern marine sediments. The gross production of biogenic silica (the transformation of dissolved silicate to particulate skeletal material) in surface waters was estimated to be 240 � 40 teramoles of silicon per year, and the preservation ratio (opal accumulation in sediment/gross production in surface waters) averages 3 percent. In the world ocean the residence time of silicon, relative to total biological uptake in surface waters, is about 400 years.
Cellular Signals Adhesion-Dependent and -Independent Neutrophils via Mediating Both Pathogen-Killing Capability and Life Span of Focal Adhesion Kinase Regulates

Various neutrophil functions such as phagocytosis, superoxide production, and survival are regulated by integrin signaling. Despite the essential role of focal adhesion kinase (FAK) in mediating this signaling pathway, its exact function in neutrophils is ill deﬁned. In this study, we investigated the role of FAK in neutrophils using a myeloid-speciﬁc conditional FAK knockout mouse. As reported in many other cell types, FAK is required for regulation of focal adhesion dynamics when neutrophils adhere to ﬁbronectin or ICAM-1. Adhesion on VCAM-1-coated surfaces and chemotaxis after adhesion were not altered in FAK null neutrophils. In addition, we observed signiﬁcant reduction in NADPH oxidase-mediated superoxide production and complement-mediated phagocytosis in FAK null neutrophils. As a result, these neutrophils displayed decreased pathogen killing capability both in vitro and in vivo in a mouse peritonitis model. In adherent cells, the defects associated with FAK deﬁciency are likely due to suppression of phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3) signaling and chemoattractant-elicited calcium signaling. Disruption of FAK also reduced chemoattractant-elicited superoxide production in suspended neutrophils in the absence of cell adhesion. This may be solely caused by suppression of PtdIns(3,4,5)P3 signaling in these cells, because the fMLP-elicited calcium signal was not altered. Consistent with decreased PtdIns(3,4,5)P3/Akt signaling in FAK null neutrophils, we also observed accelerated spontaneous death in these cells. Taken together, our results revealed previously unrecognized roles of FAK in neutrophil function and provided a potential therapeutic target for treatment of a variety of infectious and inﬂammatory diseases. Journal Immunology, 2009, 183: vascular
A Novel Ultrasonic Assisted Synthesis of Few Layered Graphene/SnO2Nanocomposite and Its Electrochemical Properties

In this study, Few Layered Graphene (FLG)/Tin oxide (SnO2) nanocomposite synthesized by ultrasonic assisted synthesis (UAS) method. The uniformly distributed SnO2 NanoParticles (NPs) on FLG observed by various characterization techniques like electron microscopy techniques (HR-TEM and FE-SEM) for structure and lattice, phase analysis studied by X-ray diffraction (XRD) and functional groups identified by FTIR. Moreover the electrochemical properties of the FLG/SnO2 nanocomposite was investigated by cyclic voltammerty. The specific capacitance of the prepared FLG/SnO2 nanocomposite exhibited superior capacitive performance with high capacitance (365 F/g), excellent cyclic performance as compared with Pure SnO2 NanoParticles. Therefore, the FLG/SnO2 nanocomposite conceivably a sustainable electrode material for super capacitor and many more energy repository devices for sustainable technological development.
Tunable Active Biquad Filter in ±0.9V 32 Nm CNFET

In this work, design and simulation of an active biquad filter based on carbon nanotube field effect transistor is presented. The filter uses current conveyor as an active element that can work up to tens of GHz range of frequencies and could be used for high frequency applications. Moreover, filtering operations in the entire Bluetooth range (2.40 - 2.48 GHz) are demonstrated via tuning of a resistor. HSPICE simulation with 32 nm CNFET model, have been carried out to test the integrity of the design.
Bivalirudin Is a Dual Inhibitor of Thrombin and Collagen-Dependent Platelet Activation in Patients Undergoing Percutaneous Coronary Intervention

Background— Bivalirudin, a direct thrombin inhibitor, is a widely used adjunctive therapy in patients undergoing percutaneous intervention (PCI). Thrombin is a highly potent agonist of platelets and activates the protease-activated receptors, PAR1 and PAR4, but it is not known whether bivalirudin exerts antiplatelet effects in PCI patients. We tested the hypothesis that bivalirudin acts as an antiplatelet agent in PCI patients by preventing activation of PARs on the platelet surface. Methods and Results— The effect of bivalirudin on platelet function and systemic thrombin levels was assessed in patients undergoing elective PCI. Mean plasma levels of bivalirudin were 2.7±0.5 &mgr;mol/L during PCI, which correlated with marked inhibition of thrombin-induced platelet aggregation and significantly inhibited cleavage of PAR1. Unexpectedly, bivalirudin also significantly inhibited collagen-platelet aggregation during PCI. Collagen induced a conversion of the platelet surface to a procoagulant state in a thrombin-dependent manner that was blocked by bivalirudin. Consistent with this result, bivalirudin reduced systemic thrombin levels by >50% during PCI. Termination of the bivalirudin infusion resulted in rapid clearance of the drug with a half-life of 29.3 minutes. Conclusions— Bivalirudin effectively suppresses thrombin-dependent platelet activation via inhibition of PAR1 cleavage and inhibits collagen-induced platelet procoagulant activity as well as systemic thrombin levels in patients undergoing PCI.
The radical of a vertex operator algebra

The radical $J(V)$ of a vertex operator algebra $V$ is defined to be the subspace of $V$ consisting of vectors $v$ such that the zero mode $o(v)=0$ on $V$ where $o(v)=v_{wt v-1}$ if $v$ is homogeneous. We establish various facts about $o(v),$ including the determination of $J(V)$ which is shown to be essentially equal to $(L(0)+L(-1))V. $
Prediction of Genes Related to Positive Selection Using Whole-Genome Resequencing in Three Commercial Pig Breeds

Selective sweep can cause genetic differentiation across populations, which allows for the identification of possible causative regions/genes underlying important traits. The pig has experienced a long history of allele frequency changes through artificial selection in the domestication process. We obtained an average of 329,482,871 sequence reads for 24 pigs from three pig breeds: Yorkshire (n = 5), Landrace (n = 13), and Duroc (n = 6). An average read depth of 11.7 was obtained using whole-genome resequencing on an Illumina HiSeq2000 platform. In this study, cross-population extended haplotype homozygosity and cross-population composite likelihood ratio tests were implemented to detect genes experiencing positive selection for the genome-wide resequencing data generated from three commercial pig breeds. In our results, 26, 7, and 14 genes from Yorkshire, Landrace, and Duroc, respectively were detected by two kinds of statistical tests. Significant evidence for positive selection was identified on genes ST6GALNAC2 and EPHX1 in Yorkshire, PARK2 in Landrace, and BMP6, SLA-DQA1, and PRKG1 in Duroc.These genes are reportedly relevant to lactation, reproduction, meat quality, and growth traits. To understand how these single nucleotide polymorphisms (SNPs) related positive selection affect protein function, we analyzed the effect of non-synonymous SNPs. Three SNPs (rs324509622, rs80931851, and rs80937718) in the SLA-DQA1 gene were significant in the enrichment tests, indicating strong evidence for positive selection in Duroc. Our analyses identified genes under positive selection for lactation, reproduction, and meat-quality and growth traits in Yorkshire, Landrace, and Duroc, respectively.
Supporting heart failure patients through personalized mobile health monitoring

Heart failure is a common chronic condition requiring frequent attention and ongoing provision of healthcare services. In this context we present a personalized mobile-based home monitoring system aiming to support heart failure patients in daily self-monitoring of their condition. An Internet-linked tablet computer and various portable and wearable sensing devices are employed in order to monitor the patient's physiological parameters and enable healthcare professionals to review patient's status remotely. The proposed system supports the activation/deactivation of system functional components by healthcare professionals during run-time operation, the unobtrusive remote upgrade of the mobile system through a private application distribution channel, and the automatic recording of user interactions, in order to meet the patient's ongoing individualized preferences and healthcare needs. Preliminary results from an observational cohort study indicate that heart failure patients find the proposed system acceptable and consider it useful for self-monitoring their condition.
JRRD at a Glance Posttraumatic stress disorder and health functioning in a non-treatment-seeking sample of Iraq war veterans : A prospective analysis

Past research indicates that war-zone veterans may experience psychological symptoms such as nightmares, difficulty experiencing happiness, and jumpiness. These and similar stress-related symptoms, if severe enough, are labeled posttraumatic stress disorder (PTSD). However, the impact of war can extend beyond psychological symptoms. This study examined 800 Army soldiers before and after they deployed to Iraq and found that higher levels of PTSD symptoms were associated with more health complaints and poorer daily functioning. These findings suggest that the impact of combat stress on health-related problems in daily life should be considered when devising optimal healthcare strategies for returning veterans.
Progressive non-fluent aphasia is not a progressive form of non-fluent (post-stroke) aphasia

Background: The speech of patients with progressive non-fluent aphasia (PNFA) has been described as similar to that in non-fluent aphasia (NFA) consequent on stroke. There are, however, few direct empirical comparisons of these two patient populations in the literature. Aims: To test the hypotheses that PNFA cases differ from NFA (a) in the extent to which their speech production deficit varies as a function of speaking task, and (b) in the nature of their phonological deficit. Methods & Procedures: Groups of PNFA and NFA patients (N = 10 each), matched on scores in a picture-naming test, were assessed on tasks of narrative picture description, reading aloud of text and single words, and phonological abilities such as rhyme judgement and rhyme production. Outcomes & Results: (a) The NFA cases showed equivalent speech rates in self-generated speech and reading text aloud, and equivalent error rates when reading text or isolated single words. In contrast, the PNFA cases spoke more rapidly when reading aloud than when producing narrative speech, and achieved higher accuracy when reading single words aloud than when reading words in text. (b) Variation in success rate for reading different types of words (e.g., content words, function words, and nonsense words), error types in reading, and performance on phonological tasks all indicated a different and better quality of phonological processing in PNFA than NFA. Conclusions: Despite some surface similarities, there are telling differences between the speech impairments in PNFA and NFA. The deficit in PNFA particularly compromises self-generated connected speech.
Chronic Ankle Instability and Neural Excitability of the Lower Extremity.

CONTEXT Neuromuscular dysfunction of the leg and thigh musculature, including decreased strength and postural control, is common in patients with chronic ankle instability (CAI). Understanding how CAI affects specific neural pathways may provide valuable information for targeted therapies. OBJECTIVE To investigate differences in spinal reflexive and corticospinal excitability of the fibularis longus and vastus medialis between limbs in patients with unilateral CAI and between CAI patients and participants serving as healthy controls. DESIGN Case-control study. SETTING Research laboratory. PATIENTS OR OTHER PARTICIPANTS A total of 56 participants volunteered, and complete data for 21 CAI patients (9 men, 12 women; age = 20.81 ± 1.63 years, height = 171.57 ± 11.44 cm, mass = 68.84 ± 11.93 kg) and 24 healthy participants serving as controls (7 men, 17 women; age = 22.54 ± 2.92 years, height = 172.35 ± 10.85 cm, mass = 69.15 ± 12.30 kg) were included in the final analyses. Control participants were matched to CAI patients on sex, age, and limb dominance. We assigned "involved" limbs, which corresponded with the involved limbs of the CAI patients, to control participants. MAIN OUTCOME MEASURE(S) Spinal reflexive excitability was assessed via the Hoffmann reflex and normalized to a maximal muscle response. Corticospinal excitability was assessed using transcranial magnetic stimulation. Active motor threshold (AMT) was defined as the lowest transcranial magnetic stimulation intensity required to elicit motor-evoked potentials equal to or greater than 100 μV in 5 of 10 consecutive stimuli. We obtained motor-evoked potentials (MEPs) at percentages ranging from 100% to 140% of AMT. RESULTS Fibularis longus MEP amplitudes were greater in control participants than in CAI patients bilaterally at 100% AMT (control involved limb: 0.023 ± 0.031; CAI involved limb: 0.014 ± 0.008; control uninvolved limb: 0.021 ± 0.022; CAI uninvolved limb: 0.015 ± 0.007; F1,41 = 4.551, P = .04) and 105% AMT (control involved limb: 0.029 ± 0.026; CAI involved limb: 0.021 ± 0.009; control uninvolved limb: 0.034 ± 0.037; CAI uninvolved limb: 0.023 ± 0.013; F1,35 = 4.782, P = .04). We observed no differences in fibularis longus MEP amplitudes greater than 110% AMT and no differences in vastus medialis corticospinal excitability (P > .05). We noted no differences in the Hoffmann reflex between groups for the vastus medialis (F1,37 = 0.103, P = .75) or the fibularis longus (F1,41 = 1.139, P = .29). CONCLUSIONS Fibularis longus corticospinal excitability was greater in control participants than in CAI patients.
Expansion and the cover time of parallel random walks

We study the cover time of parallel random walks which was recently introduced by Alon et al. [2]. We consider k parallel (independent) random walks starting from arbitrary vertices. The expected number of steps until these k walks have visited all n vertices is called cover time of G. In this paper we present a lower bound on the cover time of Ω( √n/k • √(1/Φ(G))}, where Φ(G) is the geometric expansion (a.k.a. as edge expansion or conductance). This bound is matched for any 1 ≤ k ≤ n by binary trees up to logarithmic factors. Our lower bound combined with previous results also implies a new characterization of expanders. Roughly speaking, the edge expansion Φ(G) satisfies 1/Φ(G) = O(polylog(n)) if and only if G has a cover time of O(n/k • polylog (n)) for all 1 ≤ k ≤ n. We also present new upper bounds on the cover time with sublinear dependence on the (algebraic) expansion.