Miracle-dz/UniFAR-FTUs huggingface dataset:
Vowel alternation with final i offers an easy-to-learn morphological option for a sex-blind grammatical gender in French

Like all modern Romance languages, French has a sex-based grammatical gender with two genders, feminine and masculine, and a lexicon that is highly sex-differentiated. These characteristics give rise to a number of issues, including the problematic generic use of the masculine grammatical gender, coupled with the challenge of sex categorization itself, and the epistemological difficulty of an adequate sociological description and analysis of what gender commonsense categories really are about. To remedy these concerns, several authors have proposed the creation of an additional, epicene grammatical gender. We have identified three such systematic proposals, or solutions, which specify various morphological options for new epicene nouns and gender markers on their satellite elements. These options include the use of non-standard or rarely used characters, the merging of feminine and masculine gender markers, as well as consonantal and vowel changes. In the simplest proposal, referred to as “solution I,” new epicene forms are mostly derived from feminine forms by systematically replacing with an i the final e that generally differentiates feminines from their masculine counterparts in written French. Although these solutions are used in some communities, their learnability has not been addressed so far, even though it could be a determining factor in their popularity and their eventual integration into standard French. In the present study, we provide a first assessment of this aspect by means of an online translation test. For each solution, French-speaking participants were instructed that they would be trained to learn an “alien” language that does not mark sex/gender categories (these alien languages correspond to standard French where only gendered words referring to people are replaced by the new epicene forms recommended by each solution). After a short learning-by-example phase, participants were required to translate into the alien language a set of 16 standard French sentences. The translations were analyzed as a function of several variables including the participants’ self-reported age and sex, the word categories and the solutions themselves. While all solutions proved quickly learnable, participants’ responses with solution I achieved the highest accuracy score, in particular with regard to the production of non-standard epicene forms.
Association of Childhood Oral Infections With Cardiovascular Risk Factors and Subclinical Atherosclerosis in Adulthood

Key Points Question Are childhood oral infections or inflammatory conditions associated with the risk of adulthood subclinical atherosclerosis? Findings In this cohort study of 755 participants followed up for 27 years into adulthood, a number of clinical signs of oral infections in childhood were associated with both cumulative exposure to cardiovascular risk factors during the follow-up and subclinical atherosclerosis in adulthood. Meaning Childhood oral infections may be a modifiable risk factor for adult cardiovascular disease.
Microsecond sub-domain motions and the folding and misfolding of the mouse prion protein

Protein aggregation appears to originate from partially unfolded conformations that are sampled through stochastic fluctuations of the native protein. It has been a challenge to characterize these fluctuations, under native like conditions. Here, the conformational dynamics of the full-length (23-231) mouse prion protein were studied under native conditions, using photoinduced electron transfer coupled to fluorescence correlation spectroscopy (PET-FCS). The slowest fluctuations could be associated with the folding of the unfolded state to an intermediate state, by the use of microsecond mixing experiments. The two faster fluctuations observed by PET-FCS, could be attributed to fluctuations within the native state ensemble. The addition of salt, which is known to initiate the aggregation of the protein, resulted in an enhancement in the time scale of fluctuations in the core of the protein. The results indicate the importance of native state dynamics in initiating the aggregation of proteins.
Shrub persistence and increased grass mortality in response to drought in dryland systems

Droughts in the southwest United States have led to major forest and grassland die‐off events in recent decades, suggesting plant community and ecosystem shifts are imminent as native perennial grass populations are replaced by shrub‐ and invasive plant‐dominated systems. These patterns are similar to those observed in arid and semiarid systems around the globe, but our ability to predict which species will experience increased drought‐induced mortality in response to climate change remains limited. We investigated meteorological drought‐induced mortality of nine dominant plant species in the Colorado Plateau Desert by experimentally imposing a year‐round 35% precipitation reduction for eight continuous years. We distributed experimental plots across numerous plant, soil, and parent material types, resulting in 40 distinct sites across a 4,500 km2 region of the Colorado Plateau Desert. For all 8 years, we tracked c. 400 individual plants and evaluated mortality responses to treatments within and across species, and through time. We also examined the influence of abiotic and biotic site factors in driving mortality responses. Overall, high mortality trends were driven by dominant grass species, including Achnatherum hymenoides, Pleuraphis jamesii, and Sporobolus cryptandrus. Responses varied widely from year to year and dominant shrub species were generally resistant to meteorological drought, likely due to their ability to access deeper soil water. Importantly, mortality increased in the presence of invasive species regardless of treatment, and native plant die‐off occurred even under ambient conditions, suggesting that recent climate changes are already negatively impacting dominant species in these systems. Results from this long‐term drought experiment suggest major shifts in community composition and, as a result, ecosystem function. Patterns also show that, across multiple soil and plant community types, native perennial grass species may be replaced by shrubs and invasive annuals in the Colorado Plateau Desert.
Cost-effectiveness of using an extensively hydrolyzed casein formula supplemented with Lactobacillus rhamnosus GG in managing IgE-mediated cow’s milk protein allergy in the UK

Abstract Objective: To estimate the cost-effectiveness of using an extensively hydrolyzed casein formula (eHCF) plus the probiotic Lactobacillus rhamnosus GG (eHCF plus LGG; Nutramigen* LGG®) compared to an eHCF alone as first-line dietary management for Immunoglobulin E (IgE)-mediated cow’s milk protein allergy (CMPA) in the UK. Methods: Decision modelling was undertaken to estimate the probability of IgE-mediated cow’s milk allergic infants being symptom free (i.e. not experiencing urticaria, eczema, asthma or rhinoconjunctivitis) and developing tolerance to cow’s milk by 5 years. The model also estimated the cost (at 2016/2017 prices) of healthcare resource use funded by the UK’s National Health Service (NHS) over 5 years after starting a formula, as well as the relative cost-effectiveness of the two dietary formulae. Results: At 5 years after the start of a formula the probability of being symptom free was estimated to be 0.97 and 0.76 among infants who were originally fed eHCF plus LGG and an eHCF alone, respectively. This encompassed the probability of children being asthma free at 5 years after the start of treatment, which was 0.99 and 0.91 in the eHCF plus LGG and eHCF alone groups, respectively. Additionally, the probability of acquiring tolerance to cow’s milk was estimated to be 0.94 and 0.66 among infants who were originally fed eHCF plus LGG and an eHCF alone, respectively. The estimated total healthcare cost over 5 years of initially feeding infants with eHCF plus LGG was less than that of feeding infants with an eHCF alone (£4229 versus £5136 per patient). Conclusions: First-line management of newly diagnosed infants with IgE-mediated CMPA with eHCF plus LGG instead of an eHCF alone improves outcome, releases healthcare resources for alternative use, reduces the NHS cost of patient management and thereby affords a cost-effective dietetic strategy to the NHS.
Facilitators and barriers to education for chiropractic students with visual impairment.

OBJECTIVE The purpose of this study was to document the academic experiences of students with visual impairment in a doctor of chiropractic program. METHODS Ten participants were recruited, including 3 students who are "legally blind," 2 student notetakers, 3 faculty members who taught students with visual impairment, and 2 staff members from the Disability Services Office. For this qualitative study, the students were recruited through the Disability Services Office. The participants were audiotaped during approximately 1-hour interviews conducted in a semistructured manner within a private setting (a quiet office) on the campus during office hours. Thematic analysis was conducted using a deductive method for codes and an inductive method for themes. RESULTS We identified facilitators and barriers to the education of students with visual impairment. Notable facilitators were planning for accessible educational materials, accessibility of workable space, and support systems, such as notetakers and close interaction with faculty. Notable barriers were attitudes of students with visual impairment toward their education, lack of personnel training, and lack of disability awareness in the campus community. CONCLUSION Meticulous planning of resources and communication are key to enriching academic experiences of students with visual impairment.
Genome-wide sexually antagonistic variants reveal long-standing constraints on sexual dimorphism in fruit flies

The evolution of sexual dimorphism is constrained by a shared genome, leading to ‘sexual antagonism’, in which different alleles at given loci are favoured by selection in males and females. Despite its wide taxonomic incidence, we know little about the identity, genomic location, and evolutionary dynamics of antagonistic genetic variants. To address these deficits, we use sex-specific fitness data from 202 fully sequenced hemiclonal Drosophila melanogaster fly lines to perform a genome-wide association study (GWAS) of sexual antagonism. We identify approximately 230 chromosomal clusters of candidate antagonistic single nucleotide polymorphisms (SNPs). In contradiction to classic theory, we find no clear evidence that the X chromosome is a hot spot for sexually antagonistic variation. Characterising antagonistic SNPs functionally, we find a large excess of missense variants but little enrichment in terms of gene function. We also assess the evolutionary persistence of antagonistic variants by examining extant polymorphism in wild D. melanogaster populations and closely related species. Remarkably, antagonistic variants are associated with multiple signatures of balancing selection across the D. melanogaster distribution range and in their sister species D. simulans, indicating widespread and evolutionarily persistent (about 1 million years) genomic constraints on the evolution of sexual dimorphism. Based on our results, we propose that antagonistic variation accumulates because of constraints on the resolution of sexual conflict over protein coding sequences, thus contributing to the long-term maintenance of heritable fitness variation.
Analysis of Phase-Specific Strain Pole Figures for Duplex Steels under Elasto-Plastic Uniaxial Tension—Experiment vs. EPSC Modelling

For the duplex stainless steel X2CrNiMoN22-5-3, phase-specific strain pole figures (strain PFs) for the phases ferrite (bcc) and austenite (fcc) were analysed under uniaxial tensile loading for various loading states in purely elastic and elasto-plastic regimes. Experimentally, strain PFs were determined by means of in situ neutron diffraction strain measurements under defined uniaxial loading. These experimental results were compared with strain PFs calculated using elasto-plastic self-consistent (EPSC) modelling. The comparison was performed for two different {hkl} planes per phase. While classic load stress and load partitioning analyses for multi-phase materials are often limited to the load direction and a selected direction transverse to it, the results illustrate the added value of determining a strain PF, especially when a phase-specific texture is present. The comparison with experimental data shows how well the load partitioning behaviour can be predicted using common EPSC models, using the example of a duplex stainless steel. The EPSC model used was validated with the software ISODEC in its elastic range. Based on the results of the EPSC model, and taking into account the local phase-specific crystallographic texture, a prediction can be made as to what extent intergranular stresses and phase-specific textures could affect the results of a (residual) stress analysis by means of the diffraction method. This makes it possible to assess whether, for technical applications, meaningful residual stress results can be expected in certain component directions.
Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues

ONC201 is a first-in-class imipridone molecule currently in clinical trials for the treatment of multiple cancers. Despite enormous clinical potential, the mechanism of action is controversial. To investigate the mechanism of ONC201 and identify compounds with improved potency, we tested a series of novel ONC201 analogues (TR compounds) for effects on cell viability and stress responses in breast and other cancer models. The TR compounds were found to be ∼50–100 times more potent at inhibiting cell proliferation and inducing the integrated stress response protein ATF4 than ONC201. Using immobilized TR compounds, we identified the human mitochondrial caseinolytic protease P (ClpP) as a specific binding protein by mass spectrometry. Affinity chromatography/drug competition assays showed that the TR compounds bound ClpP with ∼10-fold higher affinity compared to ONC201. Importantly, we found that the peptidase activity of recombinant ClpP was strongly activated by ONC201 and the TR compounds in a dose- and time-dependent manner with the TR compounds displaying a ∼10–100 fold increase in potency over ONC201. Finally, siRNA knockdown of ClpP in SUM159 cells reduced the response to ONC201 and the TR compounds, including induction of CHOP, loss of the mitochondrial proteins (TFAM, TUFM), and the cytostatic effects of these compounds. Thus, we report that ClpP directly binds ONC201 and the related TR compounds and is an important biological target for this class of molecules. Moreover, these studies provide, for the first time, a biochemical basis for the difference in efficacy between ONC201 and the TR compounds.
Cord blood fatty acid‐binding protein‐4 levels are upregulated at both ends of the birthweight spectrum

Fatty acid‐binding protein‐4 (FABP4) is an adipokine associated with obesity and signs of the metabolic syndrome. We aimed to investigate at birth in term neonates with normal and abnormal intrauterine growth concentrations of FABP4 and associate them with various perinatal parameters.
Development of a Simulation-Based Interprofessional Teamwork Assessment Tool.

Background The Accreditation Council for Graduate Medical Education (ACGME) Milestone projects required each specialty to identify essential skills and develop means of assessment with supporting validity evidence for trainees. Several specialties rate trainees on a milestone subcompetency related to working in interprofessional teams. A tool to assess trainee competence in any role on an interprofessional team in a variety of scenarios would be valuable and suitable for simulation-based assessment. Objective We developed a tool for simulation settings that assesses interprofessional teamwork in trainees. Methods In 2015, existing tools that assess teamwork or interprofessionalism using direct observation were systematically reviewed for appropriateness, generalizability, adaptability, ease of use, and resources required. Items from these tools were included in a Delphi method with multidisciplinary pediatrics experts using an iterative process from June 2016 to January 2017 to develop an assessment tool. Results Thirty-one unique tools were identified. A 2-stage review narrowed this list to 5 tools, and 81 items were extracted. Twenty-two pediatrics experts participated in 4 rounds of Delphi surveys, with response rates ranging from 82% to 100%. Sixteen items reached consensus for inclusion in the final tool. A global 4-point rating scale from novice to proficient was developed. Conclusions A novel tool to assess interprofessional teamwork for individual trainees in a simulated setting was developed using a systematic review and Delphi methodology. This is the first step to establish the validity evidence necessary to use this tool for competency-based assessment.
cis‐Regulatory analysis for later phase of anterior neuroectoderm‐specific foxQ2 expression in sea urchin embryos

The specification of anterior neuroectoderm is controlled by a highly conserved molecular mechanism in bilaterians. A forkhead family gene, foxQ2, is known to be one of the pivotal regulators, which is zygotically expressed in this region during embryogenesis of a broad range of bilaterians. However, what controls the expression of this essential factor has remained unclear to date. To reveal the regulatory mechanism of foxQ2, we performed cis‐regulatory analysis of two foxQ2 genes, foxQ2a and foxQ2b, in a sea urchin Hemicentrotus pulcherrimus. In sea urchin embryos, foxQ2 is initially expressed in the entire animal hemisphere and subsequently shows narrower expression restricted to the anterior pole region. In this study, as a first step to understand the foxQ2 regulation, we focused on the later restricted expression and analyzed the upstream cis‐regulatory sequences of foxQ2a and foxQ2b by using the constructs fused to short half‐life green fluorescent protein. Based on deletion and mutation analyses of both foxQ2, we identified each of the five regulatory sequences, which were 4–9 bp long. Neither of the regulatory sequences contains any motifs for ectopic activation or spatial repression, suggesting that later mRNA localization is regulated in situ. We also suggest that the three amino acid loop extension‐class homeobox gene Meis is involved in the maintenance of foxQ2b, the expression of which is dominant during embryogenesis.
Discussion of the W-Sn-REE Metallogenic Background in the Nanling Region of South China: Evidence from Satellite Gravity and Magnetic Data

The Nanling region is located at the intersection of the Yangtze Block and Cathaysia Block and is characterized by complex geological and tectonic processes, as well as distinct W-Sn-REE mineralization. Despite extensive research on the mineralization of W-Sn and REE deposits in the Nanling region, the factors impacting the distribution pattern of eastern tungsten and western tin deposits, as well as the mechanism of REE enrichment in the parent rocks, remain uncertain. Deep structural and tectonic variability plays a crucial role in the formation of mineral deposits in the upper crust. Information on deep structural and tectonic variability is contained in the Moho depth, Curie depth, effective elastic thickness, lithospheric density, and thermal structure derived from the processing and inversion of satellite gravity and magnetic data. In this paper, we comprehensively analyse satellite gravity and magnetic data from the Nanling region, integrating the processing and inversion results with the tectonic evolution of this region and relevant geological information. It is hypothesized that the Chenzhou–Linwu fault serves as a channel for mineral and thermal transfer in the Sn ore aggregation zone, facilitating the material transport from the deep mantle to the surface and ultimately leading to the formation of Sn-enriched granite. The collection area of tungsten ore is more weakly associated with the Chenzhou–Linwu fault, and through deep heat transfer, tungsten components are primarily concentrated in the Earth’s crust to produce W-enriched granite. The primary source of REE enrichment in the parent rocks associated with REE mineralization is predominantly derived from the felsic crust, and the rapid intrusion of deep magma resulting from the subduction and retraction of the Palaeo-Pacific Plate is a contributing factor to the contrasting enrichment of light and heavy rare-earth elements. Mineral crystalline differentiation is relatively high, leading to the formation of ore-forming parent rocks with high heavy rare-earth element contents.
Correlation Between Maternal Anxiety During Mid-Pregnancy and Subsequent Infant Sleep Issues: A Cross-Sectional Study from 2015 to 2016

Purpose To explore the correlation between maternal anxiety during mid-pregnancy and infant sleep issues based on the anxiety status of mothers in mid-pregnancy. Patients and Methods A cohort of 2122 primigravida women from Ma’anshan City, Anhui Province, was followed from pregnancy until 6 months postpartum. The study analyzed the impact of maternal anxiety on infant sleep patterns, including primary caregivers, encompassing insufficient sleep duration, frequent nocturnal awakenings, prolonged nocturnal awakening durations, and elongated sleep latency. Results A total of 1891 mother-infant pairs were included in this analysis. After adjusting for confounding factors, a positive correlation was found between maternal anxiety during mid-pregnancy and insufficient sleep duration (OR=1.69, 95% CI:1.13–2.52), and elongated sleep latency (OR=2.26, 95% CI:1.61–3.18). Conclusion Maternal anxiety during mid-pregnancy is associated with sleep issues in infants. Addressing maternal mental health during pregnancy may enhance sleep quality for mothers and infants, promoting overall maternal-infant health.
Effects of Slots On Resonant Frequencies of a Microstrip Patch Antenna

In this paper, a compact multiband rectangular microstrip patch antenna using slots to obtain multiple resonating frequencies, is discussed. Slots can be introduced for increasing the bandwidth, miniaturization and introducing multiband characteristics. Rectangular slots are introduced in the radiating patch, arranged in the shape of a “swastika”. Multiband characteristics is achieved due to spiral arrangement of the slots. The microstrip patch antenna is coaxial fed. FR4 epoxy resin is used for the substrate because of its rigid structure and lossy nature which enhances radiation effects. Slots of various dimensions and positions make up a swastika slot. Impact of each slot on the resonant frequencies of the RMSA is studied, their reflection coefficient analyzed and presented here.