Miracle-dz/UniFAR-FTUs huggingface dataset:
Does rotation increase the acoustic field of view? Comparative models based on CT data of a live dolphin versus a dead dolphin

Rotational behaviour has been observed when dolphins track or detect targets, however, its role in echolocation is unknown. We used computed tomography data of one live and one recently deceased bottlenose dolphin, together with measurements of the acoustic properties of head tissues, to perform acoustic property reconstruction. The anatomical configuration and acoustic properties of the main forehead structures between the live and deceased dolphins were compared. Finite element analysis (FEA) was applied to simulate the generation and propagation of echolocation clicks, to compute their waveforms and spectra in both near- and far-fields, and to derive echolocation beam patterns. Modelling results from both the live and deceased dolphins were in good agreement with click recordings from other, live, echolocating individuals. FEA was also used to estimate the acoustic scene experienced by a dolphin rotating 180° about its longitudinal axis to detect fish in the far-field at elevation angles of −20° to 20°. The results suggest that the rotational behaviour provides a wider insonification area and a wider receiving area. Thus, it may provide compensation for the dolphin’s relatively narrow biosonar beam, asymmetries in sound reception, and constraints on the pointing direction that are limited by head movement. The results also have implications for examining the accuracy of FEA in acoustic simulations using recently deceased specimens.
How Could a Student Discover Something He/She Does Not Know It Before?: What Professional Development Those Mathematic Teachers Do Need?

Thirty teachers were observed, interviewed and provided with strategic training program based and derived from the understanding of the learning theory of constructivism. The program consists partially of topics related to learning, instruction, thinking, cognition, metacognition, teachers role, which was designed to fit their needs as an in service-teacher of mathematics. data were collected through observations, interviews and survey to help them reveal as much as possible of their believes and attitudes about different concepts related to learning of mathematics. Data were analyzed quantitatively and qualitatively. The impact of training showed positive significant impact on teachers; believes and attitudes and practices.
Associations between Adult Primary Brain Tumor Survivors' Behavioral Executive Functions, Health Related Quality of Life and their Caregivers' Health Related Quality : A cross-sectional study.

The present study focused on adult primary brain tumor (PBT) survivors' caregivers. The main objective was to study associations between PBT survivors' health-related quality of life (HRQOL), their behavioral executive functions (EF) and their caregivers' HRQOL. Forty PBT survivors of PBT and 37 caregivers (mostly patient's spouses 81.08%; n = 30) participated in the study. PBT survivors completed a cancer related Quality of Life (QOL) questionnaire. Caregivers completed informant rated HRQOL and behavioral EF reports relating to PBT survivors and a self-rated HRQOL questionnaire relating to themselves. Correlational and multiple regression analyses were conducted. No associations were found between caregivers' physical HRQOL and PBT survivors' HRQOL nor behavioral EF. Analyses yielded several significant correlations between caregivers' mental HRQOL and variables pertaining to PBT survivors' HRQOL and behavioral EF. Multiple regression analyses showed that caregivers' mental HRQOL is predicted by PBT survivors' mental HRQOL, global cancer-related QOL scores and global behavioral EF scores. This study provides evidence suggesting that during the survivorship phase, at an average of 3.67 (SD = 2.31) years following treatment for a PBT, caregivers mental HRQOL is linked to PBT survivors' long-term effects. These findings shed some light regarding post-cancer care for both PBT survivors and their caregivers.
Radio emission altitudes in pulsar magnetospheres

A geometrical analysis of the pulse-profile widths at 0.43 and 1.42 GHz (Arecibo) as well as at 1.41 GHz (Effelsberg) is presented. We have measured the profile pulse widths at the lowest possible intensity level. An empirical relationship for the pulsar radio emission altitudes is proposed. We argue that for the millisecond pulsars the emission region lies close to the polar cap, as opposed to the long-period pulsars where the radiation originates few hundred km away from the surface of the neutron star.
Disc structure around strongly magnetic accretors: a full disc solution with buoyancy diffusivity

The problem of the effect of a strongly magnetic star on a surrounding accretion disc is considered. For stellar rotation periods greater than a critical value, a numerical solution is found for a steady disc with turbulent magnetic diffusion, including electron scattering opacity and radiation pressure. Inside the corotation radius, the extraction of disc angular momentum by magnetic coupling to the star becomes strong and this leads to enhanced viscous stress and dissipation. The resulting elevated temperature causes electron scattering opacity and radiation pressure to become significant further from the star than in the absence of its magnetic field. The disc ends as its height increases rapidly due to the large central pressure, its density decreases and magnetically induced viscous instability occurs.
Phased array antenna analysis with the hybrid finite element method

A new analysis technique for infinite phased array antennas was developed and demonstrated. It consists of the finite element method (FEM) in combination with integral equation radiation conditions and a novel periodic boundary condition for 3-D FEM grids. Accurate modeling of rectangular, circular and circular-coaxial feeds is accomplished by enforcing continuity between the FEM solution and several waveguide modes across an aperture in the array's ground plane. The radiation condition above the array is enforced by a periodic integral equation in the form of a Floquet mode summation, thus reducing the solution to that of a single array unit cell. The periodic boundary condition at unit cell side walls is enforced through a matrix transformation. That mathematically "folds" opposing side walls onto each other with a phase shift appropriate to the array lattice and scan angle. The unit cell electric field is expanded in vector finite elements. Galerkin's method is used to cast the problem as a matrix equation, which is solved by the conjugate gradient method. A general-purpose computer code was developed and validated for cases of open-ended waveguides, microstrip patches, clad monopoles and printed flared notches, showing that the analysis method is accurate and versatile. >
Notre-Dame de Paris: The first iron lady? Archaeometallurgical study and dating of the Parisian cathedral iron reinforcements

The study of iron reinforcements used in the construction of Notre-Dame de Paris offers a glimpse into the innovation that took place on this building site in the mid-12th century, adapting metal to create a novel architecture. The restoration of the monument after the 2019 fire offered unique possibilities to investigate its iron armatures and to sample 12 iron staples from different locations (tribunes, nave aisles and upper walls). Six of them were dated thanks to the development of an innovative methodology based on radiocarbon dating. They reveal that Notre-Dame is the first known Gothic cathedral where iron was massively used as a proper construction material to bind stones throughout its entire construction, leading to a better understanding of the master masons’ thinking. Moreover, a metallographic study and slag inclusion chemical analyses of the staples provide the first study of iron supply for a great medieval Parisian building yard, renewing our understanding of iron circulation, trade and forging in the 12th and 13th century capital of the French kingdom. The highlighting of numerous welds in all iron staples and the multiple provenances sheds light on the activity of the iron market in this major medieval European city and the nature of the goods that circulated, and questions the possible importance of recycling.
Exploration of the Production of Three Thiodiketopiperazines by an Endophytic Fungal Strain of Cophinforma mamane

Endophytic fungi possess a versatile metabolism which is related to their ability to live in diverse ecological niches. While culturing under laboratory conditions, their metabolism is mainly influenced by the culture media, time of incubation and other physicochemical factors. In this study, we focused on the production of 3 thiodiketopiperazines (TDKPs) botryosulfuranols A−C produced by an endophytic strain of Cophinforma mamane isolated from the leaves of Bixa orellana L collected in the Peruvian Amazon. We studied the time‐course production of botryosulfuranols A−C during 28 days and evaluated the variations in the production of secondary metabolites, including the TDKPs, produced by C. mamane in response to different culture media, light versus dark conditions and different incubation times. We observed a short time‐frame production of botryosulfuranol C while its production was significantly affected by the light conditions and nutrients of the culture media. Botryosulfuranols A and B showed a similar production pattern and a similar response to culturing conditions. Molecular networking allowed us to detect three compounds related to TDKPs that will be the focus of future experiments.
A Matrix Invariance Problem

where the z, are i.i. d. and distributed independently of e,, and e, is the OLS residual from (1). (a) Show that the population R of equation (2) satisfies Rl<C/(K-C + K1), (3) where C is the coefficient of variation of OJ,and K is the kurtosis of «,-. (C = aj^, where na = £(OJ,) and a 2 = £(<o, f i j 2 ; K = E(ef) = E(uf)/ lE(u)]. ) (b) Suppose that co, = z,y, and that z,consists of the squares and cross-products of Xj or some subset of them. What is the effect of C and K on the "global power" (Geweke [1]) of White's [2] test in this case?
AKR1C3 suppresses ferroptosis in hepatocellular carcinoma through regulation of YAP/SLC7A11 signaling pathway

AKR1C3 is frequently overexpressed and it is a validated therapeutic target in various tumors including hepatocellular carcinoma (HCC). Our previous study showed that AKR1C3 facilitated HCC proliferation and metastasis by forming a positive feedback loop of AKR1C3‐NF‐κB‐STAT3. Ferroptosis is a form of iron‐dependent cell death driven by iron‐dependent accumulation of lipid reactive oxygen species and plays an important role in tumor suppression. However, little is known about the role of AKR1C3 in ferroptosis susceptibility. In this study, we found that knockdown of AKR1C3 potently enhanced the sensitivity of HCC cells to ferroptosis inducers both in vitro and in vivo. Overexpression of AKR1C3 protected against ferroptosis in HCC cells. Mechanistically, AKR1C3 regulated ferroptosis through YAP/SLC7A11 signaling in HCC. AKR1C3 knockdown led to a decrease in YAP nuclear translocation, resulted in the inhibition of cystine transporter SLC7A11, and a subsequent increase in the intracellular levels of ferrous iron and ultimately ferroptosis. Moreover, we found that the combination of AKR1C3 and SLC7A11 was a strong predictor of poor prognosis in HCC. Collectively, these findings identify a novel role of AKR1C3 in ferroptosis, and highlighting a candidate therapeutic target to potentially improve the effect of ferroptosis‐based antitumor therapy.
Minimum entropy collaborative groupings: A tool for an automatic heterogeneous learning group formation

For some decades now, theories on learning methodologies have advocated collaborative learning due to its good results in terms of effectiveness and learning types and its promotion of educational and social values. This means that teachers need to be able to apply different criteria when forming heterogeneous groups of students and to use automated techniques to assist them. In this study, we have created an approach based on complex network theory to design an algorithm called Minimum Entropy Collaborative Groupings (MECG) in order to form these heterogeneous groups more effectively. The algorithm was tested firstly under a synthetic framework and secondly in a real situation. In the first case, we generated 30 synthetic classrooms of different sizes and compared our approach with a genetic algorithm and a random grouping. In the latter case, the approach was tested on a group of 200 students on two subjects of a master’s degree in teacher training. For each subject there were 4 large groups of 50 students each, in which collaborative groups of 4 students were created. Two of these large groups were used as random groups, another group used the CHAEA test and the fourth group used the LML test. The results showed that the groups created with MECG were more effective, had less uncertainty and were more interrelated and mature. It was observed that the randomized groups did not obtain significantly better LML results and that this cannot be related to any emotional or motivational effect because the students performed the test as a placebo measure. In terms of learning styles, the results were significantly better with LML than with CHAEA, whereas no significant difference was observed in the randomized groups.
The Association of Retinal age gap with metabolic syndrome and inflammation

Metabolic syndrome (MetS) is a clustering of cardiometabolic components, posing tremendous burdens in the aging society. Retinal age gap has been proposed as a robust biomarker associated with mortality and Parkinson's disease. Although MetS and chronic inflammation could accelerate the aging process and increase the risk of mortality, the association of the retinal age gap with MetS and inflammation has not been examined yet.
Long-acting antipsychotics in the treatment of schizophrenia: opportunities and challenges

ABSTRACT Introduction Maintenance antipsychotic treatment improves multiple outcomes in people with schizophrenia. These benefits are challenged by medication nonadherence, which is a common occurrence. Long-acting injectable antipsychotic (LAI) formulations were developed to reduce nonadherence and thereby improve outcomes. This narrative review is based on a PubMed search (January 2000 – August 2022) for studies on LAI antipsychotics. Areas covered Opportunities and challenges associated with LAIs are reviewed. Advantages, compared to oral antipsychotics (OAs), include improved adherence, reduced relapse and hospitalization risk, delayed and lower relapse risk after stopping treatment, and the ability to differentiate true treatment resistance from ‘pseudo’-resistance. Additionally, LAIs are associated with lower all-cause mortality than OAs. LAIs are under-used in many services, partly reflecting negative attitudes, misconceptions, and lack of knowledge among clinicians, patients, and carers. Practical barriers to LAI use include acquisition costs and inadequate service structures to administer/monitor LAI treatment. Expert opinion The education and engagement of clinicians, patients and caregivers can assist more informed decision-making regarding LAIs. Future research regarding LAIs should encompass multiple complementary designs, focus on functionality and recovery outcomes, and include groups at high risk of relapse, including those with comorbid substance use disorders and early in the course of schizophrenia.
Abatacept for Delay of Type 1 Diabetes Progression in Stage 1 Relatives at Risk: A Randomized, Double-Masked, Controlled Trial

OBJECTIVE Previous studies showed that inhibiting lymphocyte costimulation reduces declining β-cell function in individuals newly diagnosed with type 1 diabetes. We tested whether abatacept would delay or prevent progression of type 1 diabetes from normal glucose tolerance (NGT) to abnormal glucose tolerance (AGT) or to diabetes and the effects of treatment on immune and metabolic responses. RESEARCH DESIGN AND METHODS We conducted a phase 2, randomized, placebo-controlled, double-masked trial of abatacept in antibody-positive participants with NGT who received monthly abatacept/placebo infusions for 12 months. The end point was AGT or diabetes, assessed by oral glucose tolerance tests. RESULTS A total of 101 participants received abatacept and 111 placebo. Of these, 81 (35 abatacept and 46 placebo) met the end point of AGT or type 1 diabetes diagnosis (hazard ratio 0.702; 95% CI 0.452, 1.09; P = 0.11) The C-peptide responses to oral glucose tolerance tests were higher in the abatacept arm (P < 0.03). Abatacept reduced the frequency of inducible T-cell costimulatory (ICOS)+ PD1+ T-follicular helper (Tfh) cells during treatment (P < 0.0001), increased naive CD4+ T cells, and also reduced the frequency of CD4+ regulatory T cells (Tregs) from the baseline (P = 0.0067). Twelve months after treatment, the frequency of ICOS+ Tfh, naive CD4+ T cells, and Tregs returned to baseline. CONCLUSIONS Although abatacept treatment for 1 year did not significantly delay progression to glucose intolerance in at-risk individuals, it impacted immune cell subsets and preserved insulin secretion, suggesting that costimulation blockade may modify progression of type 1 diabetes.
Updates on the study of lysosomal protein dynamics: possibilities for the clinic

ABSTRACT Introduction The lysosome is the main degradative organelle of almost all mammalian cells, fulfilling important functions in macromolecule recycling, metabolism, and signaling. Lysosomal dysfunction is connected to a continuously growing number of pathologic conditions, and lysosomal proteins present potential biomarkers for a variety of diseases. Therefore, there is an increasing interest in their analysis in patient samples. Areas covered We provide an overview of OMICs studies which identified lysosomal proteins as potential biomarkers for pathological conditions, covering proteomics, genomics, and transcriptomics approaches, identified through PubMed searches. With respect to discovery proteomics analyses, mainly lysosomal luminal and associated proteins were detected, while membrane proteins were found less frequently. Comprehensive coverage of the lysosomal proteome was only achieved by ultra-deep-coverage studies, but targeted approaches allowed for the reproducible quantification of lysosomal proteins in diverse sample types. Expert opinion The low abundance of lysosomal proteins complicates their reproducible analysis in patient samples. Whole proteome shotgun analyses fail in many instances to cover the lysosomal proteome, which is due to under-sampling and/or a lack of sensitivity. With the current state of the art, targeted proteomics assays provide the best performance for the characterization of lysosomal proteins in patient samples.
AC-Bipolar Electropolymerization of 3,4-Ethylenedioxythiophene in Ionic Liquids

Recently, alternating current (AC)-bipolar electropolymerization of 3,4-ethylenedioxythiophene (EDOT) has been reported to produce poly(3,4-ethylenedioxythiophene) (PEDOT) fibers from the terminals of bipolar electrodes in acetonitrile solution (MeCN) containing low concentrations of supporting salts in a template-free manner. Here, we extend such methodology in ionic liquid (IL) media. Three kinds of ILs, diethylmethyl(2-methoxyethyl)ammonium tetrafluoroborate ([DEME][BF4]), 1-ethyl-3-methylimidazolium tetrafluoroborate ([EMIM][BF4]), and diethylmethyl(2-methoxyethyl)ammonium bis(trifluoromethylsulfonyl)imide ([DEME][TFSI]), with different electric field transmission efficiencies and diffusion coefficients were employed as solvents for the AC-bipolar electropolymerization of EDOT. A variety of PEDOT morphologies were obtained in these three ILs, showing a relationship with the physicochemical properties of the ILs. We successfully confirmed the growth of PEDOT fibers in ILs and systematically discussed the factors that influenced their growth.
Uptake and Effects of Nanoplastics on the Dinoflagellate Gymnodinium corollarium

Plastic nanoparticles (NPs) are the final state of plastic degradation in the environment before they disintegrate into low‐molecular‐weight organic compounds. Unicellular organisms are highly sensitive to the toxic effects of nanoplastics, because they are often capable of phagotrophy but are unable to consume a foreign material such as synthetic plastic. We studied the effect of polystyrene, poly(vinyl chloride), poly(methyl acrylate), and poly(methyl methacrylate) NPs on the photosynthetic dinoflagellate Gymnodinium corollarium Sundström, Kremp et Daugbjerg. Fluorescent tagged particles were used to visualize plastic capture by dinoflagellate cells. We found that these dinoflagellates are capable of phagotrophic nutrition and thus should be regarded as mixotrophic species. This causes their susceptibility to the toxic effects of plastic NPs. Living cells ingest plastic NPs and accumulate in the cytoplasm as micrometer‐level aggregates, probably in food vacuoles. The action of nanoplastics leads to a dose‐dependent increase in the level of reactive oxygen species in dinoflagellate cells, indicating plastic degradation in the cells. The introduction of a methyl group into the main chain in the α‐position in the case of poly(methyl methacrylate) causes a drastic reduction in toxicity. We expect that such NPs can be a tool for testing unicellular organisms in terms of heterotrophic feeding ability. We suggest a dual role of dinoflagellates in the ecological fate of plastic waste: the involvement of nanoplastics in the food chain and its biochemical destruction. Environ Toxicol Chem 2023;42:1124–1133. © 2023 SETAC
Pharmacological and Behavioral Interventions for Fatigue in Parkinson's Disease: A Meta-Analysis of Randomized Controlled Trials

Objective This study aims to evaluate pharmacological and behavioral interventions for the treatment of fatigue in Parkinson's disease (PD) patients. Methods We systematically searched PubMed, PsycINFO, Web of Science, EMBASE, CNKI, Wan fang, and VIP up to July 31, 2022. We used Revman 5.3 software for the meta-analysis. The outcomes included Fatigue Severity Scale (FSS) and Parkinson's Fatigue Scale (PFS). The mean difference (MD) and 95% confidence intervals (CI) were collected or calculated. Results Thirteen randomized controlled trials (RCTs) with a total of 1758 patients were included. The meta-analysis showed that current clinical treatments reduced FSS (MD: −1.60, 95% CI: −3.14 to −0.05) and PFS (MD: −0.61, 95% CI: −1.17 to −0.05) in patients with PD. Subgroup meta-analysis showed that: (1) neither pharmacological interventions nor behavioral interventions reduced FSS in PD patients; (2) dopaminergic drugs dose-dependently significantly reduced the PFS in patients with PD; (3) behavioral interventions have an almost significant effect (MD: −6.69, 95% CI: −13.71 to 0.33, P = 0.06, I2 = 74%) on alleviating PFS in PD patients; (4) vestibular rehabilitation training significantly reduced the PFS in patients with PD. Conclusions Current clinical treatments alleviate fatigue in PD patients. Dopaminergic drugs may act a stronger effect than amphetamines. Behavioral interventions, especially vestibular rehabilitation training, may be a promising way for the treatment of fatigue in patients with PD though further evidence is still needed.