Miracle-dz/UniFAR-FTUs huggingface dataset:
Dietary Intakes of Long-Chain Polyunsaturated Fatty Acids and Impulsivity: Comparing Non-Restricted, Vegetarian, and Vegan Diets

Background: Research suggests a link between deficiencies in omega-3 long-chain polyunsaturated fatty acids (LCPUFAs) and impulsivity among psychiatric populations. However, this association is less evident in non-clinical populations. As omega-3 LCPUFAs are predominantly sourced through fish consumption, non-fish dieters may be more vulnerable to higher impulsivity. Methods: This cross-sectional observational study explored the association between lower intakes of omega-3 LCPUFA food sources and higher self-reported measures of impulsivity among healthy adults consuming non-restricted, vegetarian, and vegan diets. Results: The results from the validated Food Frequency Questionnaire showed significantly lower estimated omega-3 LCPUFA intakes among vegans and vegetarians when compared with people consuming non-restricted diets. Furthermore, although all groups scored within the normal range of impulsivity measures, vegans scored comparatively higher. Vegans also scored significantly higher in impulsivity control relating to attention than those consuming non-restricted diets. Conclusions: The significantly lower omega-3 LCPUFA dietary intakes in the vegan diets were associated with higher scores in the second-order attentional aspect of self-reported impulsiveness.
3-D Lookup : Fast Protpin Structure Database Searches at 90 % ReHabi ! iW

There are far fewer classes of threedimensional protein folds than sequence families but dieproblem of detecting threedimensional similarities is NP-complete. We present a novel heuristic for identifying 3-D similarities between a query structure and the database of known protein structures. Many methods for structure alignment use a bottom-up approach, identifying first local matches andthen solving a combinatorial problem in building up larger clusters of matchingsubstructures. Here, the top-down approach is to start with the global comparison and select a rough superimposition using a fast 3-D lookup of secondary.structure motifs. The superimposmon Is then extended to an ahgnment of Coc atoms by an iterative dynamic programming step. An all-againstall compaaSson f 385 representative proteins (150,000 pair comparisons) took 1 day computer time on a single R8000 processor. In other words, one query structure is scanned against the database in a matter of minutes. The method is rated at 90 % reliability at capturing statistically significant similarities. It is useful as a rapid preprocessor to a comprehensive protein structure database search system.
Detecting Shape Similarities in 3D Pottery Repositories

Shape matching is one of the main research procedures performed by archaeologists. Real time 3D computer graphics, 3D digitisation and content based retrieval are technologies that can facilitate the automation of the shape matching process. As pottery plays a significant role in understanding ancient societies, we focus on the development of compact shape descriptors that can be used for content based retrieval of complete or nearly complete 3D pottery replicas. In this work, we present shape descriptors that exploit the axial symmetry feature and attempt to enhance the archaeological study of pottery by using 3D graphics technologies. We evaluated the performance of the descriptors using a 3D pottery ground truth repository as a test bed. We created an experimental 3D pottery search engine and attempted to integrate a content based retrieval mechanism in a 3D virtual reality environment.
Myocardial Dysfunction in Sepsis: A Large, Unsolved Puzzle

Sepsis has high incidence and mortality rates around the world. The role of cardiac depression in myocardial dysfunction during sepsis remains to be elucidated. This review attempts to summarize our understanding of the anatomical, histopathological, and pathophysiological mechanisms behind cardiac dysfunction. Biomarkers to detect cardiac depression have been used to recognize developing problems, but the actual impact of these tools remains unclear.
Abstracting of legal cases: the SALOMON experience

ing of Legal Cases: The SALOMON Experience Marie-Francine Moens, Caroline Uyttendaele, Jos Dumortier Interdisciplinary Centre for Law and IT (ICRI) K.U. Leuven Tiensestraat 41 B-3000 Leuven Belgium {marie-france.moens, caroline.uyttendaele, jos.dumortier}@law.kuleuven. ac.be
Non-cooperative available bandwidth estimation towards ADSL links

Existing tools for the estimation of the end- to-end available bandwidth require control of both end hosts of the path and this significantly limits their usability. In this paper we present ABwProbe, a single-ended tool for available bandwidth estimation against non-cooperative hosts. Although ABwProbe is general enough to be used on any Internet path, we focus our attention on ADSL links exploring the possibility of measuring the downlink available bandwidth of a non-cooperative ADSL host. We study the effect of cross-traffic on the uplink, finding that only large packets may deteriorate ABwProbe's measurements and we present two techniques to detect and filter the effect of uplink cross-traffic.
Kin recognition by self-referent phenotype matching in plants.

Fil: Crepy, Maria Andrea. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Parque Centenario. Instituto de Investigaciones Fisiologicas y Ecologicas Vinculadas a la Agricultura. Universidad de Buenos Aires. Facultad de Agronomia. Instituto de Investigaciones Fisiologicas y Ecologicas Vinculadas a la Agricultura; Argentina. Instituto Nacional de Tecnologia Agropecuaria; Argentina
Increased local dopamine secretion has growth‐promoting effects in cholangiocarcinoma

Cholangiocarcinoma is a devastating cancer of biliary origin with limited treatment options. Symptoms are usually evident after blockage of the bile duct by the tumor, and at this late stage, they are relatively resistant to chemotherapy and radiation therapy. Therefore, it is imperative that alternative treatment options are explored. We have previously shown that serotonin metabolism is dysregulated in cholangiocarcinoma leading to an increased secretion of serotonin, which has growth‐promoting effects. Because serotonin and dopamine share the degradation machinery, we evaluated the secretion of dopamine from cholangiocarcinoma and its effects on cell proliferation. Using 4 cholangiocarcinoma cell lines and human biopsy samples, we demonstrated that there was an increase in mRNA and protein expression of the dopamine synthesis enzymes tyrosine hydroxylase and dopa decarboxylase in cholangiocarcinoma. There was increased dopamine secretion from cholangiocarcinoma cell lines compared to H69 and HIBEC cholangiocytes and increased dopamine immunoreactivity in human biopsy samples. Furthermore, administration of dopamine to all cholangiocarcinoma cell lines studied increased proliferation by up to 30%, which could be blocked by the pretreatment of the D2 and D4 dopamine receptor antagonists, whereas blocking dopamine production by α‐methyldopa administration suppressed growth by up to 25%. Administration of α‐methyldopa to nude mice also suppressed cholangiocarcinoma tumor growth. The data presented here represent the first evidence that dopamine metabolism is dysregulated in cholangiocarcinoma and that modulation of dopamine synthesis may represent an alternative target for the development of therapeutic strategies.
Process Development for Preparation of Toffee from Figs

Fig is emerging as an important functional food because of its high nutritional and medicinal values. Fig is considered to be an important source of dietary fiber, vitamins and various useful minerals like Iron, Calcium, Magnesium, Copper, etc. Confectionery products due to their sweet taste and flavour are enjoyed worldwide and by all age groups. Fruit toffees contain nutrients like vitamins and minerals present in the original fruit and are nutritionally superior to milk based toffees. The present study was carried out to develop and standardize technology for preparation of fig toffees. Six types of toffee blends were prepared with the replacement of fig in the amount of 0%, 10%, 20%, 30%, 40% and 50%. It was found that toffee containing 30% fig pulp was most desirable and was kept for storage studies. Product was analyzed at an interval of 30 days to assess physico-chemical and organoleptic changes undergoing in the product. It was found that product contained crude fiber content of 2.890 per cent, protein 3.973 per cent, fat 9.877 per cent, phenolic compounds 153.253 GAE mg per 100 g, antioxidants 2460.620 per cent inhibition activity per 100g and flavonoids 15.110 mg per 100 g. Fig toffee was also found to be a good source of minerals like Calcium (235.4 mg per g), Iron (2.945 mg per g), Potassium (356.5 mg per g), Magnesium (41.93 mg per g), Sodium (157.1 mg per g) and Phosphorus (171.3 mg per g). Storage studies revealed that product was stable during three months storage study period.
Sentence Ordering in Multidocument Summarization

The problem of organizing information for multidocument summarization so that the generated summary is coherent has received relatively little attention. In this paper, we describe two naive ordering techniques and show that they do not perform well. We present an integrated strategy for ordering information, combining constraints from chronological order of events and cohesion. This strategy was derived from empirical observations based on experiments asking humans to order information. Evaluation of our augmented algorithm shows a significant improvement of the ordering over the two naive techniques we used as baseline.
A Set of Annotation Interfaces for Alignment of Parallel Corpora

Abstract Annotation interfaces for parallel corpora which fit in well with other tools can be very useful. We describe a set of annotation interfaces which fulfill this criterion. This set includes a sentence alignment interface, two different word or word group alignment interfaces and an initial version of a parallel syntactic annotation alignment interface. These tools can be used for manual alignment, or they can be used to correct automatic alignments. Manual alignment can be performed in combination with certain kinds of linguistic annotation. Most of these interfaces use a representation called the Shakti Standard Format that has been found to be very robust and has been used for large and successful projects. It ties together the different interfaces, so that the data created by them is portable across all tools which support this representation. The existence of a query language for data stored in this representation makes it possible to build tools that allow easy search and modification of annotated parallel data.
Mast cells enhance contraction of three‐dimensional collagen lattices by fibroblasts by cell–cell interaction: role of stem cell factor/c‐kit

Reorganization of the extracellular matrix is important in many biological and pathophysiological processes, including tissue remodelling, wound healing, or cancer metastasis. The ability of cultured fibroblasts to reorganize and contract three‐dimensional type I collagen gels is regarded as an in vitro model for this process. In tissue fibrosis, complex interactions among fibroblasts, inflammatory cells and the extracellular matrix are taking place. Mast cells have often been discussed to play a role in several fibrotic conditions including scleroderma, scar formation, or wound healing. In this study, we examined the effects of mast cells on contraction of collagen lattices. The results demonstrate that co‐culture of dermal fibroblasts with a human mast cell line (HMC‐1) significantly enhanced contraction of the three‐dimensional collagen lattices, whereas mast cells alone failed to contract the gel. Addition of culture supernatants of mast cells did not enhance the speed of gel contraction, indicating the importance of cell–cell contact. Morphological analysis showed that mast cells were incorporated into the lattices. Histological examination also demonstrated that within the lattices, mast cells were localized in close contact to, or attached to, fibroblasts. As fibroblasts and mast cells are known to attach via stem cell factor (SCF)/c‐kit interaction when co‐cultured in monolayers, we also examined the effect of antibodies against SCF and c‐kit in this system. Addition of both antibodies inhibited gel contraction up to 70%. In contrast, antibodies against interleukin‐4 (IL‐4) and IL‐4 receptor did not affect gel contraction. These results indicate that mast cells enhance fibroblast‐mediated contraction of collagen lattices via direct cell–cell contact, mediated in part by SCF/c‐kit interactions.
Heat Shock Protein–Peptide Complexes, Reconstituted In Vitro, Elicit Peptide-specific Cytotoxic T Lymphocyte Response and Tumor Immunity

Heat shock protein (HSP) preparations derived from cancer cells and virus-infected cells have been shown previously to elicit cancer-specific or virus-specific immunity. The immunogenicity of HSP preparations has been attributed to peptides associated with the HSPs. The studies reported here demonstrate that immunogenic HSP–peptide complexes can also be reconstituted in vitro. The studies show that (a) complexes of hsp70 or gp96 HSP molecules with a variety of synthetic peptides can be generated in vitro; (b) the binding of HSPs with peptides is specific in that a number of other proteins tested do not bind synthetic peptides under the conditions in which gp96 molecules do; (c) HSP–peptide complexes reconstituted in vitro are immunologically active, as tested by their ability to elicit antitumor immunity and specific CD8+ cytolytic T lymphocyte response; and (d) synthetic peptides reconstituted in vitro with gp96 are capable of being taken up and re-presented by macrophage in the same manner as gp96– peptides complexes generated in vivo. These observations demonstrate that HSPs are CD8+ T cell response–eliciting adjuvants.
Formulation and Evaluation of Mucoadhesive Oral Care Gel Containing Kaempferia galanga Extract

The rhizome of Kaempferia galanga (Zingiberaceae) is extensively used in traditional medicine by utilizing its various biological activities. It has been proven that ethyl-para-methoxycinnamate (EPMC) and other polyphenolic compounds are present in considerable amounts in the ethanolic extract of K. galanga rhizome (EKG). Our previous study confirmed that a dose of 0.5–1% of EKG demonstrated anti-inflammatory activity and a wound-healing effect in chemical-induced oral mucosal ulcers of Wistar rats. Currently, there are no reports on the formulation of oral gel containing EKG, thus revealing the potential of EKG to be developed as a herbal oral gel for mucosal ulcers. This study aims to formulate the best mucoadhesive oral care gel containing EKG in terms of physical stability. The presence of EPMC and the total phenols in the best EKG gel were also determined. The results revealed that Carbopol 934 is the best gelling agent for EKG gel preparations as proven by its stability during 14 days of storage. The statistical analysis resulted in a significant difference between the physical stability of the Carbopol 934-based EKG gel preparation compared to three commercial oral care gel products (p < 0.05). RP-HPLC chromatograms indicated that EPMC was identified in Carbopol 934-based gels containing 5% and 10% EKG at 6.056 and 6.146 min, respectively, with polyphenol levels of 1201.2557 mg/kg and 1849.1506 mg/kg, respectively. The hedonic test performed on 30 respondents to measure the degree of consumer acceptance and satisfaction confirmed that 5% EKG gel is the most sensorially accepted by the respondents. Data were analyzed using paired t-tests, one-way ANOVA, and a Kruskal–Wallis test. Taken together, the Carbopol 934-based gel containing 5% EKG could potentially be further developed as a topical anti-oral mucosal ulcer drug for clinical purposes.
Characteristics of Myofascial Pain Syndrome of the Infraspinatus Muscle

Objective To report the characteristics of myofascial trigger points (MTrPs) in the infraspinatus muscle and evaluate the therapeutic effect of trigger-point injections. Methods Medical records of 297 patients (221 women; age, 53.9±11.3 years) with MTrPs in the infraspinatus muscle were reviewed retrospectively. Because there were 83 patients with MTrPs in both infraspinatus muscles, the characteristics of total 380 infraspinatus muscles with MTrPs (214 one side, 83 both sides) were investigated. Specific characteristics collected included chief complaint area, referred pain pattern, the number of local twitch responses, and distribution of MTrPs in the muscle. For statistical analysis, the paired t-test was used to compare a visual analogue scale (VAS) before and 2 weeks after the first injection. Results The most common chief complaint area of MTrPs in the infraspinatus muscle was the scapular area. The most common pattern of referred pain was the anterolateral aspect of the arm (above the elbow). Active MTrPs were multiple rather than single in the infraspinatus muscle. MTrPs were frequently in the center of the muscle. Trigger-point injection of the infraspinatus muscle significantly decreased the pain intensity. Mean VAS score decreased significantly after the first injection compared to the baseline (7.11 vs. 3.74; p<0.001). Conclusion Characteristics of MTrPs and the therapeutic effects of trigger-point injections of the infraspinatus muscle were assessed. These findings could provide clinicians with useful information in diagnosing and treating myofascial pain syndrome of the infraspinatus muscle.
Digital integrated circuit testing using transient signal analysis

A novel approach to testing CMOS digital circuits is presented that is based on an analysis of I/sub DD/ switching transients on the supply rails and voltage transients at selected test points. We present simulation and hardware experiments which show distinguishable characteristics between the transient waveforms of defective and non-defective devices. These variations are shown to exist for CMOS open drain and bridging defects, located both on and off of a sensitized path.
Deep Learning Powered Identification of Differentiated Early Mesoderm Cells from Pluripotent Stem Cells

Pluripotent stem cells can be differentiated into all three germ-layers including ecto-, endo-, and mesoderm in vitro. However, the early identification and rapid characterization of each germ-layer in response to chemical and physical induction of differentiation is limited. This is a long-standing issue for rapid and high-throughput screening to determine lineage specification efficiency. Here, we present deep learning (DL) methodologies for predicting and classifying early mesoderm cells differentiated from embryoid bodies (EBs) based on cellular and nuclear morphologies. Using a transgenic murine embryonic stem cell (mESC) line, namely OGTR1, we validated the upregulation of mesodermal genes (Brachyury (T): DsRed) in cells derived from EBs for the deep learning model training. Cells were classified into mesodermal and non-mesodermal (representing endo- and ectoderm) classes using a convolutional neural network (CNN) model called InceptionV3 which achieved a very high classification accuracy of 97% for phase images and 90% for nuclei images. In addition, we also performed image segmentation using an Attention U-Net CNN and obtained a mean intersection over union of 61% and 69% for phase-contrast and nuclear images, respectively. This work highlights the potential of integrating cell culture, imaging technologies, and deep learning methodologies in identifying lineage specification, thus contributing to the advancements in regenerative medicine. Collectively, our trained deep learning models can predict the mesoderm cells with high accuracy based on cellular and nuclear morphologies.
Securing the Internet of Things: A Worst-Case Analysis of Trade-Off between Query-Anonymity and Communication-Cost

Cloud services are widely used to virtualize themanagement and actuation of the real-world the Internet ofThings (IoT). Due to the increasing privacy concerns regardingquerying untrusted cloud servers, query anonymity has becomea critical issue to all the stakeholders which are related toassessment of the dependability and security of the IoT system. The paper presents our study on the problem of query receiver-anonymityin the cloud-based IoT system, where the trade-offbetween the offered query-anonymity and the incurred communicationis considered. The paper will investigate whether theaccepted worst-case communication cost is sufficient to achieve aspecific query anonymity or not. By way of extensive theoreticalanalysis, it shows that the bounds of worst-case communicationcost is quadratically increased as the offered level of anonymityis increased, and they are quadratic in the network diameter forthe opposite range. Extensive simulation is conducted to verifythe analytical assertions.
The Comparison of Serum Interleukin-8 Levels Based on Severity of Liver Cirrhosis

Background: The molecule known as Interleukin-8 (IL-8), a chemotactic leukocyte, has been found to have a crucial role in the perpetuation of the inflammatory environment that is associated with hepatitis B virus (HBV) infection, as well as in the development of liver cirrhosis and cancer. Objective: The aim of this study was to carefully examine the role of IL-8 in the inflammatory reaction and to compare the levels based on the severity of liver cirrhosis. Methods: The study was conducted from February 2018 to September 2018 at the Gastroenterohepatology Division, Internal medicine Department, Faculty of Medicine, Universitas Sumatera Utara. The study was designed as an analytic comparative, cross-sectional study. The liver cirrhosis patients who participated in this study met the inclusion criteria and provided informed consent. Results: A total of 70 patients were included in the study, from which we identified 1 individual with child-pugh A, 28 individuals with child-pugh B, and 41 individuals with child-pugh C. The serum level of IL-8 was found to be 98 (11-320) (pg/ml). The IL-8 levels between child-pugh B and C patients did not exhibit any noteworthy differences during our analysis (p = 0.109, p>0.05). Conclusion: There is no notable inequality in the levels of IL-8 across different stages of liver cirrhosis.
Evaluation of the total petroleum hydrocarbon (TPH) standard for JP‐4 jet fuel

Abstract The potential for use of alternatives to total petroleum hydrocarbons (TPH) for remediation purposes was examined specifically for JP‐4 fuel. The study objective was to determine the scientific basis for use of fuel constituents other than TPH in establishing soil cleanup standards at JP‐4‐contaminated sites. The general bases for TPH soil cleanup standards or goals were characterized. Problems with the use of TPH for cleanup included its lack of specificity (e.g., method‐, medium‐, and time‐from‐spill‐dependency) as well as the lack of toxicological relevance. JP‐4 fuel constituents (alkanes, BTEX [i.e., benzene, toluene, ethylbenzene, xylenes], polycyclic aromatic hydrocarbons [PAHs, i.e., chrysene], and naphthalenes) were identified as potential TPH alternatives. A series of criteria were applied to assess the viability of the use of specific JP‐4 constituents as TPH alternatives, and to select the most appropriate alternative. Criteria included chemical fate and transport, toxicity, and regul.