Miracle-dz/UniFAR-FTUs huggingface dataset:
Results of a multicenter randomized clinical trial of exercise and long-term survival in myocardial infarction patients: the National Exercise and Heart Disease Project (NEHDP).

BACKGROUND This study examined whether a supervised exercise program improved 19-year survival in 30- to 64-year-old male myocardial infarction patients. METHODS AND RESULTS The men (n=651) were participants in the National Exercise and Heart Disease Project, a 3-year multicenter randomized clinical trial conducted in the United States (1976-1979). The treatment group (n=315) exercised for 8 weeks in a laboratory. Thereafter, they jogged, cycled, or swam in a gymnasium/pool setting guided by an individualized target heart rate. Participants in the control group (n=319) were to maintain normal routines but not participate in any regular exercise program. Participants were followed up until their death or December 31, 1995. Cox proportional hazards analysis revealed the all-cause mortality risk estimates (95% CIs) in the exercise group compared with controls to be 0.69 (0.39 to 1.25) after an average follow-up of 3 years, 0.84 (0.55 to 1.28) after 5 years, 0.95 (0.71 to 1.29) after 10 years, 1.02 (0.79 to 1.32) after 15 years, and 1.09 (0.87 to 1. 36) after 19 years. Cardiovascular disease (CVD) mortality risk estimates (95% CI) for the same follow-up periods were 0.73 (0.37 to 1.43), 0.98 (0.60 to 1.61), 1.21 (0.79 to 1.60), 1.14 (0.84 to 1.54), and 1.16 (0.88 to 1.52). However, each 1-MET increase in work capacity from baseline to the end of the original trial resulted in consistent reductions in all-cause and CVD mortality risk at each follow-up period, regardless of initial work-capacity level. CONCLUSIONS These findings indicate exercise-program participation resulted in nonsignificantly reduced mortality risks early in the follow-up period. Benefits diminished as time since participation increased, which suggests that the protective mechanisms associated with the program may be short term. Contamination between groups over time could also explain the diminished effects, because increased work capacity provided survival benefits up to 19 years.
A Database of Full Body Virtual Interactions Annotated with Expressivity Scores

Recent technologies enable the exploitation of full body expressions in applications such as interactive arts but are still limited in terms of dyadic subtle interaction patterns. Our project aims at full body expressive interactions between a user and an autonomous virtual agent. The currently available databases do not contain full body expressivity and interaction patterns via avatars. In this paper, we describe a protocol defined to collect a database to study expressive full-body dyadic interactions. We detail the coding scheme for manually annotating the collected videos. Reliability measures for global annotations of expressivity and interaction are also provided.
Patologias do vazio: um desafio à prática clínica contemporânea

Este trabalho procura apresentar as patologias do vazio, que incluem diagnosticos como os transtornos borderline e narcisista de personalidade, o conceito de falso self e o autismo. O presente texto baseou-se em pesquisa bibliografica sobre a teoria da tecnica psicanalitica. A teoria do desenvolvimento (principalmente a obra de Donald Winnicott) foi usada para compreender essas patologias regressivas. Uma analise de fragmento literario e um caso clinico estabelecem a ligacao entre teoria e pratica.
Genetic Basis of Drought Resistance at Reproductive Stage in Rice: Separation of Drought Tolerance From Drought Avoidance

Drought tolerance (DT) and drought avoidance (DA) are two major mechanisms in drought resistance of higher plants. In this study, the genetic bases of DT and DA at reproductive stage in rice were analyzed using a recombinant inbred line population from a cross between an indica lowland and a tropical japonica upland cultivar. The plants were grown individually in PVC pipes and two cycles of drought stress were applied to individual plants with unstressed plants as the control. A total of 21 traits measuring fitness, yield, and the root system were investigated. Little correlation of relative yield traits with potential yield, plant size, and root traits was detected, suggesting that DT and DA were well separated in the experiment. A genetic linkage map consisting of 245 SSR markers was constructed for mapping QTL for these traits. A total of 27 QTL were resolved for 7 traits of relative performance of fitness and yield, 36 QTL for 5 root traits under control, and 38 for 7 root traits under drought stress conditions, suggesting the complexity of the genetic bases of both DT and DA. Only a small portion of QTL for fitness- and yield-related traits overlapped with QTL for root traits, indicating that DT and DA had distinct genetic bases.
Are Planning, Working Memory, and Inhibition Associated With Individual Differences in Preschool ADHD Symptoms?

The association between executive function (EF; planning, working memory, and inhibition) and individual differences in symptoms of attention deficit hyperactivity disorder (ADHD) was explored in a sample of preschool children. One hundred sixty children (between the ages of 3 years, 0 months and 5 years, 6 months), selected so as to oversample high ADHD scorers, performed 3 tasks previously shown to measure planning (Tower of London), working memory (Noisy Book) and inhibition ("Puppet Says."). EF measures were reliable (k > .77) and were correlated with IQ (rs > .38) and age (rs > .59). Once IQ and age were controlled, planning and working memory (r = .41) were correlated. Planning and working memory were not correlated with inhibition (rs < .20). There was no association between ADHD and working memory or planning (rs < .12). There was a significant negative association between ADHD and conduct problems and inhibition (r = -.30 and r = -.25, respectively). Only the link with ADHD persisted after the effects of other factors were controlled for in a multiple regression. Specific deficits in inhibitory control rather than general EF deficits are associated with ADHD in the preschool period. This association is linear in nature, supporting the idea that ADHD is better seen as a continuum rather than a discrete category. This association provides evidence for Barkley's (1997) view that ADHD is underpinned by inhibitory deficits in the preschool period.
THE DIFFERENCE IN CONTACT INHIBITION OF CELL REPLICATION BETWEEN NORMAL CELLS AND CELLS TRANSFORMED BY DIFFERENT CARCINOGENS*

The transformation of normal cells into tumor cells involves a change in the control mechanism for cell replication. An approach to determining this change in control mechanism is to analyze the difference in contact inhibition' of cell replication between normal cells and cells transformed by different carcinogens. It has previously been shown that cells transformed by polyoma virus (PV),2 simian virus 40 (SV40),3 carcinogenic hydrocarbons,4' I and X irradiation' have a pattern of cell growth in culture that is more random than that of normal cells. These transformed cells, when confronted with transformed cells from the same cell line, do not show the contact inhibition of cell replication that occurs when normal cells are confronted with the same normal cells. cells The present studies were undertaken to determine whether there is contact inhibition of cell replication (1) between independently isolated clones from the same and from different species transformed by the same viral carcinogen; (2) between cells transformed by different carcinogens; and (3) between cells doubly transformed by X irradiation and PV, and cells transformed only by X irradiation or by PV; (4) to what extent X irradiation with 4000 r of cells transformed by different carcinogens can induce contact inhibition between the irradiated and unirradiated transformed cells from the same cell line; and (5) since normal cells can inhibit cells transformed by PV or carcinogenic hydrocarbons, whether this also applies to cells transformed by SV40 or X irradiation, and whether transformed cells can inhibit normal cells.
Design and Implementation of Anycast Services in Ad Hoc Networks Connected to IPv6 Networks

The paper proposes a communication model of implementing an Anycast service in an Ad Hoc network which is connected to IPv6 networks where IPv6 nodes can obtain the Anycast service provided by the Ad hoc network. In this model when an Anycast mobile member in an Ad hoc network moves it can keep the existing communications with its corresponding nodes to continue providing the Anycast services with good quality of service to IPv6 nodes. This model creates a new kind of IPv6 address auto-configuration scheme which does not need the address duplication detection. This paper deeply discusses and analyzes the model and the experimental data prove its validity and efficiency.
Unveiling group characteristics in online social games: a socio-economic analysis

Understanding the group characteristics in MMORPGs is important in user behavior studies since people tend to gather together and form groups due to their inherent nature. In this paper, we analyze the group activities of users in Aion, one of the largest MMORPGs, based on the records of the activities of 94,497 users. In particular, we focus on (i) how social interactions within a group differ from the ones across groups, (ii) what makes a group rise, sustain, or fall, (iii) how group members join and leave a group, and (iv) what makes a group end. We first find that structural patterns of social interactions within a group are more likely to be close-knit and reciprocative than the ones across groups. We also observe that members in a rising group (i.e., the number of members increases) are more cohesive, and communicate with more evenly within the group than the ones in other groups. Our analysis further reveals that if a group is not cohesive, not actively communicating, or not evenly communicating among members, members of the group tend to leave.
INTRADERMAL TRIAMCINOLONE THERAPY OF KERATOACANTHOMAS.

Triamcinolone infiltration inhibits further progression and speeds involution of solitaryand multiple-type keratoacanthomas. Further evaluation of similar materials and procedures may eventually establish a new concept in the clinical diagnosis and therapy of these self-healing neoplasms. Mandatory close cooperation and observation must be considered an essential with this technique. Failure to obtain proper therapeutic response demands surgical intervention and biopsy study.
The Evolution of Cognitive Development: Ontogeny and Phylogeny

How did the development of human intelligence evolve? To reconstruct the phylogeny of human cognitive ontogeny, Parker and McKinney systematically marshal the rapidly expanding body of empirical findings on its comparative origins and development in primates (chapters 16). Powerfully undergirding their behavioral synthesis of the evolution of primate cognitive development, Parker and McKinney provide a parallel biological synthesis of the evolution of primate physiological maturation that takes into account the range from the cellular to sexual dimorphism to life history strategy (chapters 713). Central to their biological synthesis is the comparative evolutionary origins and development of the brain in primates. Much, perhaps most, contemporary comparative research on primate cognitive development takes off from Piagets [1950a, b] genetic epistemology. Its central focus was the comparative evolution and development of sequential stages of cognition in human ontogeny and history of ideas. This led to the search for genetic parallels [Werner, 1948]. Genetic parallels, Werner argued, entail formal similarities and material differences between series of intellectual development. Just as important, I have suggested [e.g., Langer, 2000], genetic parallels also entail formal differences between series of intellectual development. Parker and McKinneys comparative thesis is that cognitive ontogeny recapitulates cognitive phylogeny subject to two crucial changes as cognitive development evolved in primates. First, the rate of cognitive development changes, its velocity is significantly different in monkeys, apes and humans. Second, the extent of cognitive development changes, with terminal elaboration of additional intellectual stages from monkeys to apes to humans. A classical discovery and analysis of the genetic parallels between the ontogenetic and historical series of ideas about space illustrate both the formal similarities and differences between them [Piaget & Inhelder, 1967]. The ontogenetic stage
Region-of-Interest 3D Video Coding Based on Depth Images

Three dimensional (3D) TV is becoming a mature technology due to the progress within areas such as display and network technology among others. However, 3D video demands a higher bandwidth in order to transmit the information needed to render or directly display several different views at the receiver. The 2D plus depth representation requires less bit rate than most 3D video representations, although the necessary views have to be rendered at the receiver. In this paper we propose to combine the 2D plus depth representation with region-of-interest (ROI) video coding to ensure a higher quality at parts of the sequence that are of interest to the viewer. These include objects close to the viewer as well as faces. This allows either the bit rate to be reduced by 12-28 % or the quality within the ROI to be increased by 0.57 - 1.5 dB, when a fixed bit rate is applied.
Parallel Space Decomposition of the Mesh Adaptive Direct Search Algorithm

This paper describes a parallel space decomposition PSD technique for the mesh adaptive direct search MADS algorithm. MADS extends a generalized pattern search for constrained nonsmooth optimization problems. The objective of the present work is to obtain good solutions to larger problems than the ones typically solved by MADS. The new method PSD-MADS is an asynchronous parallel algorithm in which the processes solve problems over subsets of variables. The convergence analysis based on the Clarke calculus is essentially the same as for the MADS algorithm. A practical implementation is described, and some numerical results on problems with up to 500 variables illustrate the advantages and limitations of PSD-MADS.
Some Feminisms and Their Implications for Accounting Practice

Uses Harding′s 1986 book. The Science Question in Feminism, as a framework for examining the implications of some feminisms for accounting. First explores feminist empiricism which challenges the exclusion of women from prominent professions. Second, addresses feminist postmodernism, which explores the differences among women and contends that no over‐arching feminist theory can be found. Third, analyses the feminist standpoint. Advocates that the current masculine system be replaced by one that is infused with a feminist perspective. Discusses and critiques each of the three theories, and explores the implications for accounting.
How to situate cognition: Letting nature take its course

1. The Situation in Cognition The situated cognition movement in the cognitive sciences, like those sciences themselves, is a loose-knit family of approaches to understanding the mind and cognition. While it has both philosophical and psychological antecedents in thought stretching back over the last century (see Gallagher, this volume, Clancey, this volume,), it has developed primarily since the late 1970s as an alternative to, or a modification of, the then predominant paradigms for exploring the mind within the cognitive sciences. For this reason it has been common to characterize situated cognition in terms of what it is not, a cluster of "anti-isms". Situated cognition has thus been described as opposed to Platonism, Cartesianism, individualism, representationalism, and even
Pitch Accent Prediction Using Ensemble Machine Learning

In this study, we applied ensemble machine learning to predict pitch accent. With decision tree as the baseline algorithm, we use popular ensemble method—boosting, at different experiment conditions, such as using acoustic features only, use text-based only, using both acoustic and text-based features to evaluate the performance of ensemble machine learning method. Pitch and Energy related acoustic features are derived from statistic methods, and we consider context influences to pitch and energy related features. Models of pitch accent (accent and unaccented) are built at the syllable level. At the same time, we compare support vector machine (SVM) to predict pitch accent at same experiment conditions. Results showed that in all experiments ensemble machine learning achieved improved performance. The best result obtained using ensemble machine learning is 82.60% accuracy to mandarin read speech.
Assessment of information efficiency of error-correcting codes in Plotkin bound

Article justifies a term of “assessment of infrmation efficiency of error-correcting codes”. It describes a model of descrete communication channel with parameters, which are nessesary for assessment of information efficiency. Authors provide a methodology of comprehensive assessment of information efficiency based on Varshamov-Gilbert, Plotkin and Shannon bounds. Made an assessment of information efficiency of error-correcting codes, which are used in DVB-T and DVB-T2 standarts. Following error-correcting codes were considered: Reed-Solomon, BCH, LDPC, convolutional codes.
Stem cell-related "self-renewal" signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma.

PURPOSE Glioblastomas are notorious for resistance to therapy, which has been attributed to DNA-repair proficiency, a multitude of deregulated molecular pathways, and, more recently, to the particular biologic behavior of tumor stem-like cells. Here, we aimed to identify molecular profiles specific for treatment resistance to the current standard of care of concomitant chemoradiotherapy with the alkylating agent temozolomide. PATIENTS AND METHODS Gene expression profiles of 80 glioblastomas were interrogated for associations with resistance to therapy. Patients were treated within clinical trials testing the addition of concomitant and adjuvant temozolomide to radiotherapy. RESULTS An expression signature dominated by HOX genes, which comprises Prominin-1 (CD133), emerged as a predictor for poor survival in patients treated with concomitant chemoradiotherapy (n = 42; hazard ratio = 2.69; 95% CI, 1.38 to 5.26; P = .004). This association could be validated in an independent data set. Provocatively, the HOX cluster was reminiscent of a "self-renewal" signature (P = .008; Gene Set Enrichment Analysis) recently characterized in a mouse leukemia model. The HOX signature and EGFR expression were independent prognostic factors in multivariate analysis, adjusted for the O-6-methylguanine-DNA methyltransferase (MGMT) methylation status, a known predictive factor for benefit from temozolomide, and age. Better outcome was associated with gene clusters characterizing features of tumor-host interaction including tumor vascularization and cell adhesion, and innate immune response. CONCLUSION This study provides first clinical evidence for the implication of a "glioma stem cell" or "self-renewal" phenotype in treatment resistance of glioblastoma. Biologic mechanisms identified here to be relevant for resistance will guide future targeted therapies and respective marker development for individualized treatment and patient selection.
Computer-aided lymph node segmentation in volumetric CT data.

PURPOSE The purpose of this work was to develop and validate a computer-aided method for the 3D segmentation of lymph nodes in CT images. The proposed method can be utilized to facilitate applications like biopsy planning, image guided radiation treatment, or assessment of response to therapy. METHODS An optimal surface finding based lymph node segmentation method was developed. Based on the approximate center point of a lymph node of interest, a graph is generated, which represents the local neighborhood around the lymph node at discrete locations (graph nodes). A cost function is calculated based on a weighted edge and region homogeneity term. By means of optimization, a surface-based segmentation of the lymph node is derived. In addition, an interactive segmentation refinement algorithm was developed, which allows the user to quickly correct segmentation errors, if needed. For assessment of segmentation accuracy, 111 lymph nodes of mediastinum, abdomen, head/neck, and axillary regions from 35 volumetric CT scans were utilized. For accuracy analysis, lymph nodes were divided into three test sets based on lymph node size and spatial resolution of the CT scan. The average lymph node size for test set I, II, and III was 1056, 1621, and 501 mm(3), respectively. Spatial resolution of test set II was lower than for test sets I and III. To generate an independent reference standard for comparison, all 111 lymph nodes were segmented by an expert with a live wire approach. RESULTS All test sets were segmented with the proposed approach. Out of the 111 lymph nodes, 40 cases (36%) required computer-aided refinement of initial segmentation results. The refinement typically required 10 s per lymph node. The mean and standard deviation of the Dice coefficient for final segmentations was 0.847 ± 0.061, 0.836 ± 0.058, and 0.809 ± 0.070 for test sets I, II, and II, respectively. The average signed surface distance error was 0.023 ± 0.171, 0.394 ± 0.189, and 0.001 ± 0.146 mm for test sets I, II, and II, respectively. The time required for locating the approximate center point of a target lymph node in a scan, generating an initial OSF segmentation, and refining the segmentation, if needed, is typically less than one minute. CONCLUSIONS Segmentation of lymph nodes in volumetric CT images is a challenging task due to partial volume effects, nearby strong edges, neighboring structures with similar intensity profiles and potentially inhomogeneous density of lymph nodes. The presented approach addresses many of these obstacles. In the majority of cases investigated, the initial segmentation method delivered results that did not require further processing. In addition, the computer-aided segmentation refinement framework was found to be effective in dealing with potentially occurring segmentation errors.
Optimización de enjambre de partículas para problemas de muchos objetivos

The difficulty to solve problems with many, possibly conflicting, objectives logically increases with the number of objectives, what makes them difficult to solve using multi-objective algorithms like the well known NSGA-II. Therefore, this work proposes the use of a particle swarm optimization (PSO) algorithm to solve many-objective problems. The main premise of this work is that MOPSO may be a good option for solving many-objective problems, presenting experimental evidence that supports this premise using the well known DTLZ benchmark with different performance metrics such as hypervolume, coverage and generational distance, among others.