Miracle-dz/UniFAR-FTUs huggingface dataset:
A fractured journey of growth: making meaning of a ‘Broken’ childhood and parental mental ill-health

ABSTRACT The psychopathological impact of parental mental ill-health on children is well known. However, little research explores positive and negative interpretations of such exposure in childhood, from the adult child's perspective. Using interpretative phenomenological Analysis this study sought subjective interpretations of the ‘lived’ experiences of growing up in a family with parental mental ill-health. A purposive sample of seven adult children provided data for analysis through semi-structured interviews. One superordinate theme: A fractured journey of growth to adulthood, overarched six subordinate themes. Four themes captured stigma, shame, social isolation and betrayal. Juxtaposed with this, two themes captured purposeful redefinition of self and psychological growth. This study captures the chronicity of traumatic distress and sense of betrayal experienced by these participants in childhood through unrelenting exposure to parental mental ill-health. However, despite unpredictability, fear, and neglect in childhood, they identified the emergence of inner strengths in adult life: unexpected growth in empathy and compassion, high resourcefulness, and personal authenticity through higher education. Findings highlight that positively redefining ‘self’ in adult life is possible in the aftermath of childhood trauma associated with parental mental ill-health. Implications for therapy include: (a) moving forward from childhood trauma and (b) managing ongoing family dynamics in adult-life.
Bootstrapping a neural net dependency parser for German using CLARIN resources

Statistical dependency parsers have quickly gained popularity in the last decade by providing a good trade-off between parsing accuracy and parsing speed. Such parsers usually rely on handcrafted symbolic features and linear discriminative classifiers to make attachment choices. Recent work replaces these with dense word embeddings and neural nets with great success for parsing English and Chinese. In the present work, we report on our experiences with neural net dependency parsing for German using CLARIN data.
Advances Multi-Channel Adaptive Directional Systems

1 Modern hearing aid technology allows the response pattern of a multi-microphone directional array to be varied in response to the acoustic environment. For example, some systems attempt to identify noise sources and respond by steering an acoustic null or nulls formed by the directional microphones toward the noise source. While this technology holds the promise of improved speech intelligibility and comfort in noise, previous implementations have not consistently translated to real-world benefits (Bentler et al., 2004). This lack of real-world benefit stems in part from microphone “drift” and subsequent microphone mismatch, which negatively affect directional microphone performance. With the introduction of Starkey Hearing Technologies’ newest products, microphone drift is minimized, resulting in a multi-microphone directional system that has stable and predictable performance over time. This article provides a tutorial on adaptive directional microphones and their performance characteristics while introducing Starkey Hearing Technologies’ solution to the problem of microphone drift. In addition, evidence-based data will demonstrate the benefit of Starkey Hearing Technologies’ new multichannel, adaptive, directional, beam-forming system.
Socialization of Soviet Youth during the "Thaw" Period: Examples of Alternative Identities in the Arkhangelsk Region

This paper considers the socialization of Soviet youth as a process of reevaluation of individual social identity in accordance with the ofﬁcially prescribed one. During the “Thaw” period, the actions and statements of many young people were marked as political protests; however, these actions are better understood as ideological discussions about Komsomol autonomy. Activities of young people who never doubted their Sovietness and of those who constructed alternative identities are analyzed in the article. The rigidity of the prescribed Sovietness made even loyal youngsters question ofﬁcial interpretations of the Soviet Union and, therefore, correct or altogether deny the Soviet core of their own identities. Thus, in the “Thaw” period we can see the beginning of the disintegration of Soviet society into numerous deideologized communities. In Russian, extended summary in English.
SELDI‐TOF as a method for biomarker discovery in the urine of aristolochic‐acid‐treated mice

Aristolochic acids (AAs) present in Aristolochia plants are substances responsible for Chinese herbs nephropathy. Recently, strong indications have also been presented, which dietary poisoning with AA is responsible for endemic (Balkan) nephropathy (EN), an enigmatic renal disease that affects rural population living in some countries in Southeastern Europe. A mouse model was applied to follow the effects of two forms of AA, AAI and AAII. SDS‐PAGE and SELDI‐TOF mass spectrometry with normal phase chips were used to evaluate changes in the urine of treated animals. These two methods are demonstrated to be comparable. The use of SELDI‐TOF MS for rapid analysis of a large number of samples and the combination of this method with nano‐LC‐ESI MS/MS for protein identification were demonstrated. Biomarker discovery after analysis of large cohort of EN patients will be the final aim of these investigations.
Building Penetration Measurements and Feasibility Study for Indoor Coverage of Ku-Band Satellite Signals

This paper describes a technique which can be used for wideband satellite signal power measurements. This method consists in measuring signal's power within its spectral mask for a certain period of time. A series of measurements has been carried out not only for evaluating the derived results of the proposed method, but also for the computation of building penetration loss for indoor satellite coverage. The results of this measurement campaign showed site and frequency dependence and they were evaluated by comparing results obtained using this method for signals of both vertical and horizontal polarization as well. Penetration loss for satellite signals can be modeled using regression models for both polarizations.
Combining independent and joint learning: a negotiation based approach

This work presents a new class of multiagent reinforcement learning algorithms that takes advantage of negotiation in order to improve the process of action selection. In this class of algorithms, agents use communication to cooperate and negotiate over the joint actions, thus enhancing the process of action selection. In this paper a new algorithm in this class is proposed: the Negotiation-based Q-Learning (NQL), which uses negotiation in the context of the Q-Learning algorithm. Results show that allowing negotiation between agents significantly enhances the performance of the multi-agent learning process.
Cervical Spine Motion During Tracheal Intubation with Manual In-Line Stabilization: Direct Laryngoscopy versus GlideScope® Videolaryngoscopy

BACKGROUND: The optimal tracheal intubation technique for patients with potential cervical (C) spine injury remains controversial. Using continuous cinefluoroscopy, we conducted a prospective study comparing C-spine movement during intubation using direct laryngoscopy (DL) or GlideScope® videolaryngoscopy (GVL), with uninterrupted manual in-line stabilization of the head by an assistant. METHODS: Twenty patients without C-spine pathology were studied. After induction of general anesthesia with neuromuscular blockade, both DL and GVL were performed on every patient in random order. Cinefluoroscopic images of C-spine movement during GVL and DL were acquired and divided into four stages: a baseline image before airway manipulation, glottic visualization, insertion of the endotracheal tube into the glottis, and tracheal intubation. Peak segmental motion from the occiput to C5 was measured offline for each patient and each stage, averages were calculated, and movements induced by each instrument were compared using a two-way ANOVA. Also studied were the proportion of patients with occiput-C1 rotation exceeding 10, 15, or 20 degrees, and the quality of glottic visualization. RESULTS: No significant difference was found between DL and GVL regarding average segmental spine movement at any level (P values between 0.22 and 0.70). During both techniques, motion was mainly an extension concentrated in the rostral C-spine and occurred predominantly during glottic visualization. The proportion of patients with occiput-C1 extension of more than 10, 15, or 20 degrees was not significantly different. Glottic visualization was significantly better with GVL compared with DL. CONCLUSION: During intubation under general anesthesia with neuromuscular blockade and manual in-line stabilization, the use of GVL produced better glottic visualization, but did not significantly decrease movement of the nonpathologic C-spine when compared with DL.
A low-cost perspective in identifier-based services of supply chains

Several major challenges of todaypsilas industrial production, especially in supply chains and production networks with ongoing changes and critical customer demands, can be answered by introducing tracking and tracing services and extending them, over organizational borders, to the entire network in question. The pioneering track-and-trace solutions introduced by large companies can, due to their expenses as well as their lack of flexibility, hardly be the preferred choice for networks of smaller enterprises, and even the mainstream of todaypsilas new off-the-shelf business integration platforms is not targeting the small business sector. The paper highlights the key problems to be overcome for successful introduction of lean but extensible entry-level track-and-trace solutions and presents the concept and first pilot application results of the ongoing R & D project TraSer in this field.
Technical Standardization Status and the Advanced Strategies of the Next Generation Mobile Communications

4th generation mobile communication service is high quality seamless broadband multimedia service, which can be used by less cost and more convenience. This service should be possible with anything, anytime, anywhere, anydevice, anyone (AAAAA). Competition has already been begun. We have enough know-how about 2G and 3G mobile communication systems. With these strengths, if we keep producing and providing highly advanced services using 4 generation mobile communication technologies, our country can make a firm foundation to lead worldwide market in 4 generation mobile communication. In addition, our country will be still one of the most powerful countries in IT area
P-glycoprotein-Mediated Active Efflux of the Anti-HIV1 Nucleoside Abacavir Limits Cellular Accumulation and Brain Distribution

P-glycoprotein (P-gp)-mediated efflux at the blood-brain barrier has been implicated in limiting the brain distribution of many anti-HIV1 drugs, primarily protease inhibitors, resulting in suboptimal concentrations in this important sanctuary site. The objective of this study was to characterize the interaction of abacavir with P-gp and determine whether P-gp is an important mechanism in limiting abacavir delivery to the central nervous system (CNS). In vitro and in vivo techniques were employed to characterize this interaction. Abacavir stimulated P-gp ATPase activity at high concentrations. The cellular accumulation of abacavir was significantly decreased by ∼70% in Madin-Darby canine kidney II (MDCKII)-MDR1 monolayers compared with wild-type cells and was completely restored by the P-gp inhibitors ((R)-4-((1aR,6R,10bS)-1,2-difluoro-1,1a,6,10b-tetrahydrodibenzo(a,e)cyclopropa(c)cycloheptan-6-yl)-α-((5-quinoloyloxy)methyl)-1-piperazineethanol, trihydrochloride) (LY335979) and N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide (GF120918). Directional flux experiments indicated that abacavir had greater permeability in the basolateral-to-apical direction (1.58E-05 cm/s) than in the apical-to-basolateral direction (3.44E-06 cm/s) in MDR1-transfected monolayers. The directionality in net flux was abolished by both LY335979 and GF120918. In vivo brain distribution studies showed that the AUCplasma in mdr1a(-/-) CF-1 mutant mice was ∼2-fold greater than the AUCplasma in the wild type, whereas the AUCbrain in the mutant was 20-fold higher than that in the wild type. Therefore, the CNS drug targeting index, defined as the ratio of AUC brain-to-plasma for mutant over wild type, was greater than 10. These data are the first in vitro and in vivo evidence that a nucleoside reverse transcriptase inhibitor is a P-gp substrate. The remarkable increase in abacavir brain distribution in P-gp-deficient mutant mice over wild-type mice suggests that P-gp may play a significant role in restricting the abacavir distribution to the CNS.
Network parameters and heuristics in practice: a case study using the target set selection problem

It is well known that many real-world networks (‘complex’ networks), such as social, biological and communication networks, have distinctive topological features. However, in general, it is an open question whether or not these features can provide any algorithmic benefits. In this paper, we introduce ideas from the area of parametrized complexity to try and provide a partial answer to this question. We investigate the values of some of the parameters commonly employed by the parametrized complexity community in a range of real social, biological and communication networks. In all cases, the parameter values are much too high to be of practical use. Because of this lack of tractability in practice, we investigate dynamic strategies for exploiting the distinctive topological features of real-world networks to improve the prospects for efficient computation of acceptable problem solutions, using both fixed-parameter and greedy approaches. Our strategies involve simple targeted operations: vertex deletion and edge addition, which could easily be applied in cases such as social networks. As a case study, we consider the target set selection problem, a ubiquitous problem that models many problems concerning the spread of information in networks.
Risk factors and outcome of transfusion-related acute lung injury in the critically ill: A nested case–control study*

Objectives:To determine the incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of critically ill patients. Design:In a retrospective cohort study, patients with transfusion-related acute lung injury were identified using the consensus criteria of acute lung injury within 6 hrs after transfusion. Inclusion criterion was a length of intensive care unit admission >48 hrs. Patients developing transfusion-related acute lung injury were matched (on age, sex, and admission diagnosis) to transfused control subjects and patients developing acute lung injury from another origin. Setting:Tertiary referral hospital. Patients:All first-admitted patients from November 1, 2004, until October 1, 2007, to the intensive care unit. Interventions:None. Measurements and Main Results:Of 5208 admitted patients, 2024 patients had a length of stay >48 hrs, of whom 109 were suspected transfusion-related acute lung injury cases. Compared with transfused control subjects, risk factors for transfusion-related acute lung injury were emergency cardiac surgery (odds ratio, 17.6 [1.8–168.5]), hematologic malignancy (odds ratio, 13.1 [2.7–63.8]), massive transfusion (odds ratio, 4.5 [2.1–9.8]), sepsis (odds ratio, 2.5 [1.2–5.2]), mechanical ventilation (odds ratio, 3.0 [1.3–7.1], and high Acute Physiology and Chronic Health Evaluation II score (odds ratio, 1.1 [1.0–1.1]; p < .03 for all). The volume of platelets and plasma transfused was associated with transfusion-related acute lung injury in the univariate analysis. However, this association disappeared in the multivariate analysis. Compared with acute lung injury control subjects, risk factors for transfusion-related acute lung injury were sepsis (odds ratio, 2.4 [1.1–5.3]) and high Acute Physiology and Chronic Health Evaluation II score (odds ratio, 1.1 [1.0–1.1]), whereas pneumonia (odds ratio, 0.4 [0.2–0.7]) was a negative predictive factor. Patients with transfusion-related acute lung injury had a longer duration of mechanical ventilation compared with transfused control subjects and acute lung injury control subjects (231 [138–472] vs. 71 [46–163] and 70 [42–121] hrs, p < .001). Also, 90-day survival of patients with transfusion-related acute lung injury was lower compared with transfused control subjects and acute lung injury control subjects (53% vs. 75% and 83%, p < .02). Conclusions:Transfusion-related acute lung injury is common in critically ill patients. Transfusion-related acute lung injury may contribute to an adverse outcome associated with transfusion. This study identifies transfusion-related acute lung injury risk factors, which may aid in assessing the risks and benefits of transfusion in critically ill patients.
Conditioning Injury-Induced Spinal Axon Regeneration Requires Signal Transducer and Activator of Transcription 3 Activation

Sensory axons in the adult spinal cord do not regenerate after injury. This is essentially because of inhibitory components in the damaged CNS, such as myelin-associated inhibitors and the glial scar. However, if the sciatic nerve is axotomized before injury of the dorsal column, injured axons can regenerate a short distance in the spinal cord. Here, we show that sciatic nerve transection results in time-dependent phosphorylation and activation of the transcription factor, signal transducer and activator of transcription 3 (STAT3), in dorsal root ganglion (DRG) neurons. This effect is specific to peripheral injuries and does not occur when the dorsal column is crushed. Sustained perineural infusion of the Janus kinase 2 (JAK2) inhibitor AG490 to the proximal nerve stump can block STAT3 phosphorylation after sciatic nerve transection and results in reduced growth-associated protein 43 upregulation and compromised neurite outgrowth in vitro. Importantly, in vivo perineural infusion of AG490 also significantly attenuates dorsal column axonal regeneration in the adult spinal cord after a preconditioning sciatic nerve transection. We conclude that STAT3 activation is necessary for increased growth ability of DRG neurons and improved axonal regeneration in the spinal cord after a conditioning injury.
Effect of Heat Treatment on Mechanical and Setting Properties of TTCP-Based Calcium Phosphate Cement

The objective of this study was to investigate the effect of heat treatment on setting reaction and mechanical properties of tetracalcium phosphate (TTCP) and dicalcium phosphase (DCP)-based calcium phosphate cements. CPC pastes were prepared at room temperature and heated at different temperatures (from 37 to 60°C) for 10 min. Then, the preheated CPC pastes were rapidly cooled down to room temperature before further heated at 37°C until they set. Three different CPC formulations prepared from different particle sizes of TTCPs were used for the investigation. From the study, it was found that preheating could accelerate setting reaction for all CPCs according to increasing speed of hydroxyapatite (HA) conversion. The higher the preheating temperature, the faster the cements could set. However, at preheating temperature higher than 60°C longer cement setting times were observed. It may be that at high temperature some liquid content in the CPC paste evaporated, resulting in slow setting reaction rate. Compressive strengths of the cements after immersion in simulated body fluid (SBF) for 7 days increased as a result of an increase of HA conversion.
A ‘Demented Work Ethic’ and a ‘Lifestyle Firm’: Discourse, Identity, and Workplace Time Commitments

One key to understanding the contours of late modernity is to examine workers’ allocations of time to their organizations. In this article, I frame workplace time commitments as the outcome of two forces: individuals’ efforts to portray a positive and distinctive identity (identity work) and the organizational and social discourses shaping those identities (identity regulation). Analysis of interviews with 53 employees from two distinct organizations shows that identity work and identity regulation related to workplace time commitments are not the result of totalizing managerial discourses, but are influenced by the arrays of discursive resources proffered by both locales and organizational practices. Importantly, these arrays tend to ‘tilt’ toward agency or structure in the conceptions of the individual–organization relationship they afford. Based on this finding, I argue that studies of workplace control and resistance should examine the features of such arrays of discursive resources, that understanding these assemblies of discursive resources can provide insight on the institutionalization of workplace practices, and that claims about modernity's totalizing influences on identity must be tempered by considering locale-specific discourses.
Near fine grain parallel processing using static scheduling on single chip multiprocessors

With the increase of the number of transistors integrated on a chip, efficient use of transistors and scalable improvement of effective performance of a processor are getting important problems However, it has been thought that popular superscalar and VLIW world have difficult to obtain scalable improvement of effective performance in future because of the limitation of instruction level parallelism. To cope with this problem, a single chip multiprocessor (SCM) approach with multi grain parallel processing inside a chip, which hierarchically exploits loop parallelism and coarse grain parallelism among subroutines, loops and basic blocks in addition to instruction level parallelism, is thought one of the most promising approaches. This paper evaluates effectiveness of the single chip multiprocessor architectures with a shared cache, global registers, distributed shared memory and/or local memory for near fine grain parallel processing as the first step of research on SCM architecture to support multi grain parallel processing. The evaluation shows OSCAR (Optimally Scheduled Advanced Multiprocessor) architecture having distributed shared memory and local memory in addition to centralized shared memory and attachment of global register gives us significant speed rip such as 13.8% to 143.8% for four processors compared with shared cache architecture for applications which have been difficult to extract parallelism effectively.