Miracle-dz/UniFAR-FTUs huggingface dataset:
Heterologous Immunological Effects of Early BCG Vaccination in Low-Birth-Weight Infants in Guinea-Bissau: A Randomized-controlled Trial

Background. Bacillus Calmette–Guérin (BCG) seems to have beneficial nonspecific effects; early BCG vaccination of low-birth-weight (LBW) newborns reduces neonatal mortality by >40% due to prevention of primarily septicemia and pneumonia. Methods. Within a randomized trial in LBW infants in Guinea-Bissau of early BCG vs the usual postponed BCG, a subgroup was bled 4 weeks after randomization. Levels of interleukin (IL)-1β, IL-5, IL-6, IL-10, IL-17, interferon (IFN)-γ and tumor necrosis factor (TNF)-α were measured from whole-blood assays stimulated with innate agonists to Toll-like receptor (TLR)-2, -4 or -7/8, or purified protein derivative (PPD). Results. Among 467 infants, BCG significantly increased the in vitro cytokine responses to purified protein derivative of Mycobacterium tuberculosis (PPD), as expected. BCG was also associated with increased responses to heterologous innate stimulation, particularly of the cytokines IL-1β, IL-6, TNF-α, and IFN-γ. Conclusion. Four weeks after immunization, BCG-vaccinated infants have a significantly increased production of cytokines upon heterologous challenge, particularly T helper cell type 1 polarizing and typically monocyte-derived pro-inflammatory cytokines. BCG may accelerate the development of the neonatal immune system, mediating comprehensive protection against infections and mortality.
Determinants and prognostic implications of persistent ST-segment elevation after primary angioplasty for acute myocardial infarction: importance of microvascular reperfusion injury on clinical outcome.

BACKGROUND Despite early recanalization of an occluded infarct artery, reperfusion at the level of the microcirculation may remain impaired owing to a process of microvascular reperfusion injury. METHODS AND RESULTS Microvascular reperfusion injury was studied in 91 patients with acute myocardial infarction (AMI) by evaluation of the resolution of ST-segment elevation after successful PTCA. Impaired microvascular reperfusion, defined as the presence of persistent (>/=50% of initial value) ST-segment elevation (ST >/=50%) at the end of coronary intervention, was observed in 33 patients (36%) and was independently correlated with low systolic pressure on admission and high age. Patients >/=55 years of age with systolic pressures </=120 mm Hg were at high risk for development of impaired reperfusion compared with patients not meeting these criteria (72% versus 14%, P<0.001). Impaired microvascular reperfusion was associated with a more extensive infarction and worse clinical outcome at the 1-year follow-up: cardiac death rate, 15% versus 2% (ST >/=50% versus ST <50%, P=0.01); nonfatal MI rate, 9% versus 2% (P=0.1); and total major adverse cardiac event (MACE) rate, 45% versus 15% (P<0.005). ST >/=50% was the most important independent determinant of MACE with an adjusted risk ratio of 3.4. CONCLUSIONS Impaired microvascular reperfusion, as evidenced by ST >/=50% after successful recanalization, occurs in more than one third of our AMI patients, especially in older patients with low systolic pressure. Its detrimental implications on clinical outcome reinforce the need to develop adjunctive agents that attenuate the process of reperfusion injury.
Ju n 20 05 Possible Optical Detection of the Anomalous X-ray Pulsar CXOU J 010043 . 1 − 721134

Archival Hubble Space Telescope Wide Field/Planetary Camera 2 observations of the Small Magellanic Cloud serendipitously reveal a possible counterpart to the Anomalous X-ray Pulsar CXOU J010043.1−721134. The candidate is faint, but its location and strange colours make it an interesting object. We estimate , that the probability of such a detection being due to a non-physical source is less than 1.5%. We have tried to confirm the identification with Gemini-South and Magellan, but the conditions were insufficiently favourable. If confirmed, the object will allow the first detailed studies of the optical and ultraviolet emission of magnetars.
Collision-Free Workspace Design of the 5-Axis Gantry-Tau Parallel Kinematic Machine

This paper describes the workspace of the 5-axis variant of the Gantry-Tau parallel manipulator. The 5-axis movements are achieved by extending the 3-axis Gantry-Tau with two linear telescope link actuators. A new analytic inverse kinematic solution for the 5-axis machine and an analysis of the collision-free zones of the machine are presented. The results show that by careful design of the manipulated platform, a collision-free 5-axis workspace can be achieved. The achievable re-orientation of 30 degrees in the entire workspace is large for a parallel kinematic machine
Mycobacterium tuberculosis Infection in Complement Receptor 3-Deficient Mice1

Complement receptor type 3 (CR3) present on macrophages is used by Mycobacterium tuberculosis as one of its major phagocytic receptors. In this study, we examined the in vivo significance of CR3-mediated phagocytosis on the pathogenesis of disease caused by M. tuberculosis. The outcome of tuberculous infection in mice deficient in the CD11b subunit of CR3 (CR3−/−) on a mixed 129SV and C57BL background and control wild-type counterparts was comparable with respect to survival, bacterial burden, granulomatous lesion development, and cytokine expression in the spleen and lungs. M. tuberculosis infection was also examined in CR3−/− mice on C57BL/6 and BALB/c backgrounds and was found to be similar. In conclusion, our results suggest that in the absence of CR3, M. tuberculosis is able to gain entry into host cells via alternative phagocytic receptors and establish infection. The data also indicate that absence of CR3 does not alter disease course in either the relatively resistant C57BL/6 or the relatively susceptible BALB/c strains of mice.
Information seeking behavior of crime scene investigators in the Turkish National Police.

This exploratory research is the first one among occupational information seeking behavior studies that focuses on information seeking behaviors of the crime scene investigators. The data used in this dissertation were gathered via a self-administrated survey instrument from 29 cities in Turkey. Findings obtained from the data analyses show that there is a strongly positive relationship between the experience of the crime scene investigators and the use of personal knowledge and experience as a primary information source (experience is operationalized with age, service years in policing, and service years in crime scene investigation units). The findings also suggest that increasing of the level of education is negatively related to relying on immediate colleagues as an information source among the crime scene investigators. These findings are consistent with related literature and theory. The data analysis shows that crime scene investigators work in cities with higher population rates have more complaint scores than those who work in cities with lower population rates across Turkey. The findings from the data analysis may suggest valuable implications to defeat the barriers between crime scene investigators and information sources. The researcher drew a proposed theoretical framework of an information behavior concept in the context of crime scene investigation that may help those who are interested in the phenomenon and its applications to other contexts.
Hyaluronic Acid Filler in HIV-Associated Facial Lipoatrophy: Evaluation of Tissue Distribution and Morphology with MRI

Objective: This prospective observational study evaluated magnetic resonance imaging (MRI) findings of hyaluronic acid (HA) injections used for the correction of HIV-associated facial lipoatrophy. Methods: Ten consecutive males underwent subdermal HA injection (mean 1.3 ± 0.6 ml per side) and MRI examinations prior to and then 1, 6 and 12 months after injection. Two radiologists blinded to the clinical data assessed morphologic and quantitative changes. Results: MRI revealed HA deposition in the subdermal and deep fat compartments. A significant HA volume increase was observed 1 month after injection (mean increase 331%, p < 0.0001) as compared to the injected amount. No volume reduction occurred at 12 months (p = 0.9961). The measured bound water content did not change (p > 0.9991), whereas skin thickness and tissue vascularization increased during the first 6 months (p = 0.01). Conclusion: Our data show that the cosmetic results of HA injections are caused by water binding in the deep facial fat and by a transient increase in vascularization and skin thickness.
The effects of 8 weeks of regular aerobic exercise on the symptoms of premenstrual syndrome in non-athlete girls

Background: Premenstrual syndrome (PMS) is a combination of physical, psychological, or behavioral changes in the late secretary phase of menstrual cycle and interferes with interpersonal relationships or activities. The purpose was to assess the effects of 8 weeks of regular aerobic exercise on PMS in non-athlete girls. Materials and Methods: This quasi-experimental study was conducted on 40 non-athlete girl students aged 18-25 years at Khorasgan Azad University, with a diagnosis of PMS. The instruments included personal information and a medical questionnaire, a form of premenstrual symptoms DSM-IV, the GHQ 28 questionnaire, and the Beck Depression and Anxiety questionnaire, and also, daily symptoms were recorded for 4 months (two courses before the training period and two during training). Individuals in the experimental group practiced aerobic exercise for 8 weeks, three sessions per week for 60 min. The subjects were evaluated during the first (the pre-test), second (the mid-test), and third menstrual period (the post-test). Statistical analysis used in this study is t-test and repeated measurement analysis of variance (ANOVA). Results: Results showed that the mean scores of PMS and symptoms declined after 8 weeks of training in the experimental group. The comparison of the two groups showed that the mean scores of PMS, for symptoms during and after exercise, were significantly different (P ≤ 0.001) and the percentages of scores PMS changes, physical, and psychological symptoms of experimental and control groups had a significant difference (P ≤ 0.001) after 8 weeks of training. Conclusions: Overall, the findings showed that 8 weeks of aerobic exercise is effective in reducing the symptoms of PMS and can be used as a treatment.
Peer-to-Peer Infrastructure for Multi-knowledge Workflows

The general aim of the Multi-Knowledge project is to develop a collaborative environment to allow networks of co-operating medical research centres to create, exchange and manipulate new knowledge from heterogeneous data sources. The Multi-Knowledge service-oriented architecture (MK-SOA) will enable workflow design and execution based on novel operating procedures to manage and combine heterogeneous data and make them easily available for the imputation of study algorithms. In this paper we focus on the peer-to-peer infrastructure we have developed to support the creation of a fully decentralized collaborative environment, in which each party remains autonomous and the interactions between services are seen from a global perspective.
Socio-economic factors and tuberculosis: a district-based ecological analysis in Hong Kong.

BACKGROUND Relatively little is known about the impact of socio-economic factors on tuberculosis in a metropolitan city with high disease incidence. METHOD District-specific tuberculosis notification rates for 1995--1997 and 2000--2002 were indirectly sex- and age-adjusted and compared with the socio-economic characteristics in the 1996 by-census and 2001 census. RESULTS The differences between the 18 districts persisted after 3-year averaging and indirect standardisation. Only the percentage of population born locally, the percentage of the population widowed or divorced and the percentage of households residing in rooms or bedsits were consistently associated with the standardised notification ratios (SNR) for both periods, the first being negatively so (all P < 0.05). In a combined analysis with a general linear model for both periods, birth in China, residence <7 years, speaking other Asian languages, being married and in a single household were also significantly associated with the SNR (all P < 0.05). Using a backward conditional approach, only local birth, being married, and residing in rooms or bedsits were independent predictors of SNR (all P < 0.05). There was no significant association between SNR and socio-economic indices on education, occupation, unemployment and income. CONCLUSION Socio-economic factors other than simple poverty are affecting the district-specific tuberculosis rates in Hong Kong.
Early detection of response to radiation therapy in patients with brain malignancies using conventional and high b-value diffusion-weighted magnetic resonance imaging.

PURPOSE To study the feasibility of using diffusion-weighted magnetic resonance imaging (DWMRI), which is sensitive to the diffusion of water molecules in tissues, for detection of early tumor response to radiation therapy; and to evaluate the additional information obtained from high DWMRI, which is more sensitive to low-mobility water molecules (such as intracellular or bound water), in increasing the sensitivity to response. PATIENTS AND METHODS Standard MRI and DWMRI were acquired before and at regular intervals after initiating radiation therapy for 10 malignant brain lesions in eight patients. RESULTS One week posttherapy, three of six responding lesions showed an increase in the conventional DWMRI parameters. Another three responding lesions showed no change. Four nonresponding lesions showed a decrease or no change. The early change in the diffusion parameters was enhanced by using high DWMRI. When high DWMRI was used, all responding lesions showed increase in the diffusion parameter and all nonresponding lesions showed no change or decrease. Response was determined by standard MRI 7 weeks posttherapy. The changes in the diffusion parameters measured 1 week after initiating treatment were correlated with later tumor response or no response (P <.006). This correlation was increased to P <. 0006 when high DWMRI was used. CONCLUSION The significant correlation between changes in diffusion parameters 1 week after initiating treatment and later tumor response or no response suggests the feasibility of using DWMRI for early, noninvasive prediction of tumor response. The ability to predict response may enable early termination of treatment in nonresponding patients, prevent additional toxicity, and allow for early changes in treatment.
A Population-Based Study on Alcohol and High-Risk Sexual Behaviors in Botswana

Background In Botswana, an estimated 24% of adults ages 15–49 years are infected with HIV. While alcohol use is strongly associated with HIV infection in Africa, few population-based studies have characterized the association of alcohol use with specific high-risk sexual behaviors. Methods and Findings We conducted a cross-sectional, population-based study of 1,268 adults from five districts in Botswana using a stratified two-stage probability sample design. Multivariate logistic regression was used to assess correlates of heavy alcohol consumption (>14 drinks/week for women, and >21 drinks/week for men) as a dependent variable. We also assessed gender-specific associations between alcohol use as a primary independent variable (categorized as none, moderate, problem and heavy drinking) and several risky sex outcomes including: (a) having unprotected sex with a nonmonogamous partner; (b) having multiple sexual partners; and (c) paying for or selling sex in exchange for money or other resources. Criteria for heavy drinking were met by 31% of men and 17% of women. Adjusted correlates of heavy alcohol use included male gender, intergenerational relationships (age gap ≥10 y), higher education, and living with a sexual partner. Among men, heavy alcohol use was associated with higher odds of all risky sex outcomes examined, including unprotected sex (AOR = 3.48; 95% confidence interval [CI], 1.65 to 7.32), multiple partners (AOR = 3.08; 95% CI, 1.95 to 4.87), and paying for sex (AOR = 3.65; 95% CI, 2.58 to 12.37). Similarly, among women, heavy alcohol consumption was associated with higher odds of unprotected sex (AOR = 3.28; 95% CI, 1.71 to 6.28), multiple partners (AOR = 3.05; 95% CI, 1.83 to 5.07), and selling sex (AOR = 8.50; 95% CI, 3.41 to 21.18). A dose-response relationship was seen between alcohol use and risky sexual behaviors, with moderate drinkers at lower risk than both problem and heavy drinkers. Conclusions Alcohol use is associated with multiple risks for HIV transmission among both men and women. The findings of this study underscore the need to integrate alcohol abuse and HIV prevention efforts in Botswana and elsewhere.
Is lanreotide and/or interferon alfa an adequate therapy for neuroendocrine tumors?

TO THE EDITOR: Faiss et al [1] report on a prospective, randomized trial investigating the antiproliferative effect of lanreotide and interferon alfa in 80 patients with metastatic neuroendocrine tumors. This is one of the largest prospective series ever reported. The authors assumed a 300% increase in 1-year progression-free survival when combining lanreotide and interferon alfa compared to interferon alfa alone. However, the study was prematurely closed after 80 patients instead of the calculated 105 patients. Furthermore, the authors do not provide the basis for their assumptions of a 15% progression-free survival at 1 year for interferon and 25% for lanreotide, respectively. Interpretation of some of the data presented has to be considered inaccurate and uncommon. Subgroups of eight to 12 patients each comparing symptom control cannot be analyzed statistically, and we doubt the clinical accuracy and relevance of one versus two or two versus three episodes of flush and/or diarrhea per day. Eleven patients crossed over, achieving a “clear reduction in tumor growth”—response criteria should be well defined and applied. Finally, the authors’ point out their low disease stabilization (DS) rate compared with other reports, making four statements that are not supported by the literature. (1) The authors explain that the low DS rate is due to a large amount of foregut tumors. However, most other series do not specify the tumor localization and contain a high number of unknown primary sites [2,3]. Some series report on a comparable high number of foregut tumors, but obtain a higher DS-rate [4]. (2) Their study is not unique in having independent radiologic review [2-4]. (3) The authors claim that lanreotide is inferior to octreotide, although it has been demonstrated that both somatostatin analogs are equivalent [4,5]. (4) It is not clear why therapy-naive patients should show a lower stable disease rate than patients who already received treatments. Unfortunately, the study presented shows some inconsistent results. In addition, although it is a large series of patients with this rare disease, the accrual could not be completed and thus did not reach statistical significance.
Accuracy of respiratory rate monitoring using a non-invasive acoustic method after general anaesthesia.

BACKGROUND Respiratory rate should be monitored continuously in the post-anaesthesia care unit (PACU) to avoid any delay in the detection of respiratory depression. Capnometry is the standard of care but in extubated patients requires a nasal cannula or a face mask that may be poorly tolerated or can be dislodged, leading to errors in data acquisition and false alarms. The value of a new non-invasive acoustic monitor in this setting has not been fully investigated. METHODS Adult patients admitted to the PACU after general anaesthesia were included. After tracheal extubation, an adhesive sensor with an integrated acoustic transducer (RRa™) was placed on the patient's throat and connected to its monitor while the patient breathed through a face mask with a carbon dioxide sampling port (Capnomask™) connected to a capnometer. Both the acoustic monitor and the capnometer were connected to a computer to record one pair of data per second for up to 60 min. RESULTS Fifty-two patients, mean (range) age 54 (22-84) yr and BMI 26 (19-39) kg m(-2), were studied. Compared with capnometry, the bias and limits of agreement of the acoustic method were 0 (-1.4-1.4) bpm. The acoustic sensor was well tolerated while the face mask was removed by eight patients, leading to study discontinuation in two patients. CONCLUSIONS In extubated patients, continuous assessment of respiration rate with an acoustic monitor correlated well with capnometry.
Cabling the Vassiliev Invariants

We characterise the cabling operations on the weight systems of finite type knot invariants. The eigenvectors and eigenvalues of this family of operations are described. The canonical deframing projection for these knot invariants is described over the cable eigenbasis. The action of immanent weight systems on general Feynman diagrams is considered, and the highest eigenvalue cabling eigenvectors are shown to be dual to the immanent weight systems. Using these results, we prove a recent conjecture of Bar-Natan and Garoufalidis on cablings of weight systems.
Methods for implantation of micro-wire bundles and optimization of single/multi-unit recordings from human mesial temporal lobe

Objective. The authors report methods developed for the implantation of micro-wire bundles into mesial temporal lobe structures and subsequent single neuron recording in epileptic patients undergoing in-patient diagnostic monitoring. This is done with the intention of lowering the perceived barriers to routine single neuron recording from deep brain structures in the clinical setting. Approach. Over a 15 month period, 11 patients were implanted with platinum micro-wire bundles into mesial temporal structures. Protocols were developed for (A) monitoring electrode integrity through impedance testing, (B) ensuring continuous 24-7 recording, (C) localizing micro-wire position and ‘splay’ pattern and (D) monitoring grounding and referencing to maintain the quality of recordings. Main results. Five common modes of failure were identified: (1) broken micro-wires from acute tensile force, (2) broken micro-wires from cyclic fatigue at stress points, (3) poor in vivo micro-electrode separation, (4) motion artifact and (5) deteriorating ground connection and subsequent drop in common mode noise rejection. Single neurons have been observed up to 14 days post-implantation and on 40% of micro-wires. Significance. Long-term success requires detailed review of each implant by both the clinical and research teams to identify failure modes, and appropriate refinement of techniques while moving forward. This approach leads to reliable unit recordings without prolonging operative times, which will help increase the availability and clinical viability of human single neuron data.
A fully cell-based design for timing measurement of memory

This work presents a scheme for measuring the timing parameters of a memory's I/O interface — including the setup/hold time and access time. For setup/hold time measurement, we incorporate a procedure that successively adjusts the timing relation between the clock signal and a controllable valid timing window to estimate the setup/hold time. For access time measurement, we propose a circuit that can capture the worst-case access time of an entire Built-In Self-Test (BIST) session as a pulse width, which is then further measured by traditional time-to-digital converter (TDC). Instead of just reporting a digital code, we also propose a calibration scheme so that we can report not just some digital codes, but also their corresponding absolute values. All the design can be constructed by standard cells. We have implemented it in TSMC 0.18nm CMOS process technology. Simulation results show that the setup time error is less than 3%, the hold time error is 7.5%, and the access time error is 4.4%, with about 6.2% area overhead when the memory size is 4096×64.