Miracle-dz/UniFAR-FTUs huggingface dataset:
Bioglass® Coatings on Biodegradable Poly(3‐hydroxybutyrate) (P3HB) Meshes for Tissue Engineering Scaffolds

Osteoconduction and non‐toxic bioresorbability can be achieved by combining Bioglass® particles and Poly (3‐hydroxybutyrate) (P3HB) fibre meshes in novel composites for tissue engineering scaffolds. Bioglass® coatings readily induce hydroxyapatite (HA) formation on fibre surfaces in vitro, while biodegradable P3HB yields non toxic degradation products. In the present investigation, P3HB meshes were used, which were generated by means of an embroidery technology on the basis of yarns with 12 and 24 filaments with diameters of ∼ 30 μm. Bioglass® particles of average particle size < 5 μm were used to produce coatings on P3HB meshes by slurry dipping. By varying the concentration of Bioglass® particles in aqueous slurry, coating thickness and homogeneity could be controlled. Optimally coated meshes were incubated in simulated body fluid (SBF) for 3, 7, 14, and 21 days to detect formation of HA, as a qualitative assessment of bioactivity. Scanning electron microscopy (SEM) observations coupled with X‐ray diffraction analyses revealed the presence of HA crystals on mesh surfaces following 3 days of incubation in SBF. The amount of HA crystals was shown to increase with incubation time in SBF. Minimal polymer degradation was seen after 21 days in SBF, suggesting a suitable time frame for tissue replacement. The novel Bioglass® /P3HB composite meshes developed here are potential materials for bone tissue engineering scaffold applications.
Empathic painting: interactive stylization through observed emotional state

We present the "empathic painting" --- an interactive painterly rendering whose appearance adapts in real time to reflect the perceived emotional state of the viewer. The empathic painting is an experiment into the feasibility of using high level control parameters (namely, emotional state) to replace the plethora of low-level constraints users must typically set to affect the output of artistic rendering algorithms. We describe a suite of Computer Vision algorithms capable of recognising users' facial expressions through the detection of facial action units derived from the FACS scheme. Action units are mapped to vectors within a continuous 2D space representing emotional state, from which we in turn derive a continuous mapping to the style parameters of a simple but fast segmentation-based painterly rendering algorithm. The result is a digital canvas capable of smoothly varying its painterly style at approximately 4 frames per second, providing a novel user interactive experience using only commodity hardware.
Security analysis of robust data-hiding with geometrically structured codebooks

In digital media transfer, geometrical transformations desynchronize the communications between the encoder and the decoder. Therefore, an attempt to decode the message based on the direct output of the channel with random geometrical state fails. The main goal of this paper is to analyze the conditions of reliable communications based on structured codebooks in channels with geometrical transformations. Structured codebooks include codewords that have some features or statistics designed for synchronization purposes. In the design of capacity approaching data-hiding codes, host interference problem should be resolved. The solution to this problem is to perform the message coding based on random binning dependent on host-state. On the other hand, to achieve robustness to geometrical transformations, the codewords should have host independent statistics and encoding should be performed using random coding. To satisfy these conflicting requirements we propose Multiple Access Channel (MAC) framework where the message is split between two encoders designed based on the random binning and random coding principles. The message encoded according to random coding additionally serves for synchronization purposes. Sequentially, all existing methods that are proposed for reliable communications in channels with geometrical transformations are analyzed within the proposed MAC set-up. Depending on the particular codebook design, we classify these methods into two main groups: template-based codebooks and redundant codebooks. Finally, we perform the analysis of security leaks of each codebook structure in terms of complexity of the worst case attack.
A Development Model Supporting Integrative Object Oriented Middlewares for Sensor and Actuator Networks

Today there are many proposals of middlewares for sensor and actuator networks (SAN). Each of them introduces programming paradigms for creating distributed applications. There are middlewares with different philosophies in terms of architecture and organization (database, clustering, etc.). From the standpoint of the programmer these considerations influence the development process and, in most cases, determine the programming paradigm. Although these middlewares are so different, there is a common issue: they assume the SAN is logically separated from the main network. Thus, it forces the programmers to think a lot on specific stuff for the SAN and provides a dissociated vision of the whole system. In this paper we propose a new development model for SAN based on standard object oriented middlewares. Moreover, we provide a language as a new programming paradigm so that it is possible to have a homogeneous view of the whole system (including main network and the SAN).
MECHANISM OF CHIP FORMATION IN HIGH-SPEED TURNING OF INCONEL 718

The mechanism of serrated chip formation during high-speed turning of Inconel 718 using PCBN cutting tools has been investigated with the aid of scanning electron microscopy and optical microscopy. A conceptual model of chip formation has been developed knowing the chip morphology. It is followed by the analysis of chip segmentation frequency and the chip forms. Further, the chip segment forms and geometry were quantitatively characterized as a function of machining parameters and the cutting edge geometry using statistical methods. The chip morphology has been correlated with the cutting forces, specific shearing energy and the resultant roughness of the machined surfaces.
Formal Specification and Evaluation of Components Interaction in Software Architectures

Software Architecture refers to a high-level specification of structures and behaviors of software components. This specification can be used for evaluating non-functional attributes, even before software implementation, and therefore it results in early detection and correction of defects. In this way, formal methods are more rigorous and systematic and make it possible to automatically verify different aspects of software architectures. In this paper we introduce a framework to formally specify and evaluation of Software Architectures. The frame work includes an algorithm for transforming Software Architecture described in UML to a powerful and formal model, called Team Automata. The framework also proposes a performance model over obtained formal descriptions. This model is used for specifying, evaluating and enhancing the architecture of a Web-Service software, under flash-crowd condition and the results of analysis and experiments are presented.
How action influences object perception

Although object perception is typically associated with the parvocellular (P) pathway, a form of fast “gist” object perception may be due to activity in the magnocellular (M) pathway (Kveraga et al., 2007). Because the M-pathway is typically associated with action, we hypothesized that manipulations of action would influence speeded object perception. In three experiments, participants indicated whether the objects shown in low and high spatial frequency (HSF) images were larger or smaller than a prototypical shoebox. In Experiment 1, participants used a proximal (hands on monitor) or distal (hands on keyboard) hand posture in separate blocks. In Experiment 2, only the proximal hand posture was used, but the hands were either action oriented with palms in (palms toward the stimuli) or non-action oriented with palms out (palms away from the stimuli). In Experiment 3, we used the palms-in proximal hand posture but manipulated the type of visual stimuli such that they were either action oriented (easily grasped) or non-action oriented (not easily grasped). In all three experiments, the advantage in identifying the low spatial frequency (LSF) images was greater when action was primed (proximal hands, palms-in, graspable). Together, these experiments show that the M-pathway is involved in rapid “gist” object perception, and this type of object perception is influenced by action.
Model for Forecasting Passenger of Airport Farzane Ahmadzade

This research forecasts the growth of air traffic in one of int’l airport. It actually estimates the growth of air traffic with the trend model, and then the growth is forecasted by monthly air traffic and time series data. To estimate the coefficient of the model in general econometric methods use the time series data, it is suggested that the data should be stationary, otherwise false regression would be probable. Then before using, the data (variables), the data should be tested so as to be stationary. However, there are different methods to make data stationary such as Drawing Diagram and Augmented DickeyFuller Test (ADF), which were used in this dissertation. Finally, the estimation is base on the fifth month, namely (Mordad).
Unfolding Convex Polyhedra via Radially Monotone Cut Trees

A notion of "radially monotone" cut paths is introduced as an effective choice for finding a non-overlapping edge-unfolding of a convex polyhedron. These paths have the property that the two sides of the cut avoid overlap locally as the cut is infinitesimally opened by the curvature at the vertices along the path. It is shown that a class of planar, triangulated convex domains always have a radially monotone spanning forest, a forest that can be found by an essentially greedy algorithm. This algorithm can be mimicked in 3D and applied to polyhedra inscribed in a sphere. Although the algorithm does not provably find a radially monotone cut tree, it in fact does find such a tree with high frequency, and after cutting unfolds without overlap. This performance of a greedy algorithm leads to the conjecture that spherical polyhedra always have a radially monotone cut tree and unfold without overlap.
CONSIDERATIONS OF ALLOWABLE STRESS OF CORROSION FATIGUE (FOCUSED ON THE INFLUENCE OF PITTING)

Abstract— Long life corrosion fatigue behaviour is discussed. The importance of (i) quantification of corrosion pit depth (or surface roughness caused by corrosion) as a function of service period and (ii) corrosion pit modelling is emphasized. Extreme value statistics is useful for corrosion pit depth quantification. It is demonstrated that a corrosion pit can be treated as an elliptical crack with the same depth and surface length as a pit. From these considerations, a method for determination of a reasonable allowable stress in corrosion fatigue is proposed. Finally, an example of an allowable stress is given, i.e. the allowable stresses of a real machine component under rotating bending stress are determined from estimation curves of pit depth together with corrosion fatigue crack growth data.
Induction of proinflammatory cytokines by a soluble factor of Propionibacterium acnes: implications for chronic inflammatory acne

Although many cytokines have been implicated in the development and persistence of inflammatory immune responses, it is unknown if any of these are important in inflammatory acne. This study investigated the production of the proinflammatory cytokines interleukin-8 (IL-8), IL-1 beta, and tumor necrosis factor alpha (TNF-alpha) by human monocytic cell lines, ThP-1 and U937, and by freshly isolated peripheral blood mononuclear cells from acne patients. Both Propionibacterium acnes and supernatants obtained from 72-h P. acnes cultures could induce significant concentrations of IL-1 beta, TNF-alpha, and IL-8 by both cell lines and by peripheral blood mononuclear cells as determined by enzyme-linked immunosorbent assay. There was no significant difference between acne and non-acne subjects. Endotoxin quantification and addition of polymyxin B to assays indicated no lipopolysaccharide (LPS) contamination. P. acnes supernatant was fractionated into components with molecular weights of < 3,000, < 10,000, and < 30,000 and assayed for the ability to induce IL-8 and TNF production in ThP-1 cells. Nearly 90% of the original activity was found in the < 30,000-molecular-weight fraction, 50% was in the < 10,000-molecular-weight fraction, and only 15% remained in the < 3,000-molecular-weight fraction. The effluent from the < 3,000-molecular-weight fraction contained about 70% activity, indicating that the inducing factor was not retained in the membrane. Incubation of P. acnes supernatant with various concentrations of mutanolysin or lysozyme resulted in a loss of 60% of the original activity. The addition of jimson lectin, which binds peptidoglycan, resulted in a loss of 70% of the activity in a dose-response manner, whereas peanut lectin had little or no effect on the activity. Heating of the P. acnes supernatant to 65 degrees C also had no effect on the activity. Blocking of CD14, a receptor for both LPS and peptidoglycan, reduced cytokine production by > 50%, suggesting that the soluble stimulating factor may be a secreted form of peptidoglycan-polysaccharide.
From cytology to histology: diagnosis of a relapsed mediastinal lymphoma by endobronchial ultrasound transbronchial histological needle

Endobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA) is highly accurate in diagnosing mediastinal lymphadenopathies of lung cancer and benign disorders, with the advantage that it is a minimally invasive technique, unlike open surgery and mediastinoscopy. However, the diagnostic accuracy of EBUS‐TBNA for the diagnosis of lymphoma in patients with mediastinal lymphadenopathy is not well defined. The lack of tissue architecture obtained by cytological needles decreases the diagnostic accuracy for diagnosis and subtyping of de novo and relapsed mediastinal lymphomas. We present the first described case in the literature of an anaplastic large cell lymphoma relapsed, diagnosed on tissue fragments obtained by EBUS‐TBNA with the particularity of using a histological needle.
Porosity Assessment of β-Spodumene/Glass Matrix Composites by Small Angle Neutron Scattering

Small Angle Neutron Scattering (SANS) is used to study the microstructure of spodumene/glass matrix composites prepared by sintering of soda-lime glass powder and sol-gel prepared -spodumene (LiAlSi2O6) up to 25wt. %. The glass matrix reinforcement with spodumene results in fracture toughness, hardness and thermal shock resistance increasing. SANS allows distinguishing micro-pores inside -spodumene agglomerates and large sized pores in the glass matrix that result from incomplete densification during the sintering cycle. It is proved that composites with dispersed phase contents below 15 wt. % are homogeneous, whereas for larger contents, such -spodumene particle aggregates are observed inside the glass. Also, for high spodumene contents, e.g. 25wt. %, the crystallisation of anorthoclase in the glass matrix occurs in parallel with the sintering process. Comparison of porosity and total surface area results obtained by SANS proves that the dimensional changes related to such phase transformation result in surplus macro-porosity and cracking, while micro-porosity does not develop.
An improved high-throughput screening assay for tunicamycin sensitivity in Arabidopsis seedlings

Tunicamycin (Tm) sensitivity assays are a useful method for studies of endoplasmic reticulum stress and the unfolded protein response in eukaryotic cells. While Tm sensitivity and Tm recovery assays have been previously described, these existing methods are time-consuming, labor intensive, and subjected to mechanical wounding. This study shows an improved method of testing Tm sensitivity in Arabidopsis using liquid Murashige and Skoog medium versus the traditional solid agar plates. Liquid medium bypasses the physical manipulation of seedlings, thereby eliminating the risk of potential mechanical damage and additional unwanted stress to seedlings. Seedlings were subjected to comparative treatments with various concentrations of Tm on both solid and liquid media and allowed to recover. Determination of fresh weight, chlorophyll contents analysis and qRT-PCR results confirm the efficacy of using liquid medium to perform quantitative Tm stress assays.
Platform of Rich Internet Application for Wireless Sensor Network

As Web based software has developed recently, service via web has increased gradually. For this, many research organizations and reports call Web is the platform of software. While Web based technologies have developed, middleware of WSN and its application service has been developed from desktop based operation system. So WSN's technology reached uppermost limit of desktop application. There's difficulty in integrating, distributing and maintaining and repairing for WSN due to a tightly-coupled structure which is related closely to the hardware of sensor node. Unlike this, web has a loosely-coupled structure and an opened system, so Web service or rich Internet application (RIA) is helpful to solve the above limits. Especially, RIA is web application but can be the platform of WSN' application because it gives us various methods to communicate with user interface similar to desktop application. In this study, the author suggest RIA operation environment for WSN, expanding WSN's interconnectedness and accessibility to Internet.
Occupational factors and carpal tunnel syndrome.

Carpal tunnel syndrome (CTS) is the most commonly reported nerve entrapment syndrome. The prevalence of CTS among 652 active workers in jobs with specific hand force and repetitiveness characteristics was estimated. The prevalence of CTS ranged from 0.6% among workers in low force-low repetitive jobs to 5.6% among workers in high force-high repetitive jobs. When controlling for potential confounders, the odds ratio for the high force-high repetitive jobs was more than 15 (p less than .001) compared to the low force-low repetitive jobs. High repetitiveness appears to be a greater risk factor than high force (odds ratio of 5.5 p less than .05 versus 2.9 and not statistically significant).
An Approach to Outlier Detection of Software Measurement Data using the K-means Clustering Method

The quality of software measurement data affects the accuracy of project manager's decision making using estimation or prediction models and the understanding of real project status. During the software measurement implementation, the outlier which reduces the data quality is collected, however its detection is not easy. To cope with this problem, we propose an approach to outlier detection of software measurement data using the k-means clustering method in this work.
Integrated Modeling of Gene Regulatory and Metabolic Networks in Mycobacterium tuberculosis

Mycobacterium tuberculosis (MTB) is the causative bacterium of tuberculosis, a disease responsible for over a million deaths worldwide annually with a growing number of strains resistant to antibiotics. The development of better therapeutics would greatly benefit from improved understanding of the mechanisms associated with MTB responses to different genetic and environmental perturbations. Therefore, we expanded a genome-scale regulatory-metabolic model for MTB using the Probabilistic Regulation of Metabolism (PROM) framework. Our model, MTBPROM2.0, represents a substantial knowledge base update and extension of simulation capability. We incorporated a recent ChIP-seq based binding network of 2555 interactions linking to 104 transcription factors (TFs) (representing a 3.5-fold expansion of TF coverage). We integrated this expanded regulatory network with a refined genome-scale metabolic model that can correctly predict growth viability over 69 source metabolite conditions and predict metabolic gene essentiality more accurately than the original model. We used MTBPROM2.0 to simulate the metabolic consequences of knocking out and overexpressing each of the 104 TFs in the model. MTBPROM2.0 improves performance of knockout growth defect predictions compared to the original PROM MTB model, and it can successfully predict growth defects associated with TF overexpression. Moreover, condition-specific models of MTBPROM2.0 successfully predicted synergistic growth consequences of overexpressing the TF whiB4 in the presence of two standard anti-TB drugs. MTBPROM2.0 can screen in silico condition-specific transcription factor perturbations to generate putative targets of interest that can help prioritize future experiments for therapeutic development efforts.
Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: a children's oncology group study.

PURPOSE Imatinib mesylate is a targeted agent that may be used against Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL), one of the highest risk pediatric ALL groups. PATIENTS AND METHODS We evaluated whether imatinib (340 mg/m(2)/d) with an intensive chemotherapy regimen improved outcome in children ages 1 to 21 years with Ph+ ALL (N = 92) and compared toxicities to Ph- ALL patients (N = 65) given the same chemotherapy without imatinib. Exposure to imatinib was increased progressively in five patient cohorts that received imatinib from 42 (cohort 1; n = 7) to 280 continuous days (cohort 5; n = 50) before maintenance therapy. Patients with human leukocyte antigen (HLA) -identical sibling donors underwent blood and marrow transplantation (BMT) with imatinib given for 6 months following BMT. RESULTS Continuous imatinib exposure improved outcome in cohort 5 patients with a 3-year event-free survival (EFS) of 80% +/- 11% (95% CI, 64% to 90%), more than twice historical controls (35% +/- 4%; P < .0001). Three-year EFS was similar for patients in cohort 5 treated with chemotherapy plus imatinib (88% +/- 11%; 95% CI, 66% to 96%) or sibling donor BMT (57% +/- 22%; 95% CI, 30.4% to 76.1%). There were no significant toxicities associated with adding imatinib to intensive chemotherapy. The higher imatinib dosing in cohort 5 appears to improve survival by having an impact on the outcome of children with a higher burden of minimal residual disease after induction. CONCLUSION Imatinib plus intensive chemotherapy improved 3-year EFS in children and adolescents with Ph+ ALL, with no appreciable increase in toxicity. BMT plus imatinib offered no advantage over BMT alone. Additional follow-up is required to determine the impact of this treatment on long-term EFS and determine whether chemotherapy plus imatinib can replace BMT.