Miracle-dz/UniFAR-FTUs huggingface dataset:
Provision security in SDN/NFV

Software-defined networks (SDNs) are a new approach to building networks, which has given impetus to the development of many technologies used as the basis for many modern applications, such as access control that is based on policies, network virtualization and others. Introduction of the software allows you to increase flexibility and accelerate the return on investment in network structures. On the other hand, this increases the complexity of the system and causes the need for funds to ensure their security and correctness. SDN components can solve these problems. Network Functions Virtualization (NFV) creates new opportunities for networking professionals, but it also leads to problems related to security. The problem of development and description of common interfaces for security NFV and associated technologies is facing a number of Internet service providers and network equipment manufacturers. This paper provides a comprehensive overview of issues related to security in software-defined networks and network virtualization functions.
An RCS-like retinal dystrophy phenotype in mer knockout mice.

PURPOSE To determine whether mice that are homozygous for a targeted disruption of the Mer receptor tyrosine kinase gene (mer(kd)) manifest a retinal dystrophy phenotype similar to RCS rats, which carry a mutation in the orthologous gene MERTK: METHODS Eyes of mer(kd) and C57BL/6 wild-type (WT) mice were examined by light and electron microscopy, whole-eye rhodopsin measurement, and Ganzfeld electroretinography (ERG). RESULTS The mer(kd) mice showed rapid, progressive degeneration of the photoreceptors (PRs). Features of the phenotype common to mer(kd) mice and RCS rats included the absence or near absence of phagosomes in the retinal pigment epithelium (RPE) at the peak of outer segment (OS) disc shedding, accumulation of debris and whorls of membranes at the RPE-OS interface, transient supernormal rhodopsin content and OS lengths, the presence of OS vacuoles beginning at early ages, and a relatively slow removal of pyknotic PR nuclei. Most PRs were missing, and OS debris was removed by approximately postnatal day (P)45. Scotopic ERG responses were lower than age-matched WT responses and declined with PR loss. Photopic responses were preserved better than scotopic responses, corresponding with preferential cone preservation as judged histologically. ERG amplitudes were usually unmeasurable beyond P40, although a small-amplitude scotopic threshold response (STR) could still be elicited at P253 in some mice when only scattered PR nuclei remained. CONCLUSIONS Ablation of Mer function in mer(kd) mice results in a retinal phenotype almost identical with that of RCS rats. The similarity in phenotypes between the two rodent models suggests that an RPE phagocytic defect is a feature of all types of retinal degeneration caused by loss of function of Mer tyrosine kinase, perhaps including mutations in human MERTK.
Genetic Variability of the European Corn Borer, Ostrinia nubilalis, Suggests Gene Flow Between Populations in the Midwestern United States

Abstract The European corn borer, Ostrinia nubilalis (Hübner) (Lepidoptera: Crambidae), is a widely distributed and serious economic pest to corn production in the U.S. Genetic variability of O. nubilalis was studied in 18 sub-populations in the upper Midwestern United States using amplified fragment length polymorphism. The relatively low GST values indicate that more variation exists within populations than between populations. High gene flow (Nm) values were indicated across the entire O. nubilalis population; the lowest degree of gene flow was in the northern samples (Nm = 1.96) and the highest degree of gene flow was in the southern samples (Nm = 2.77). The differences observed in the respective regions (north vs. south) may be explained by the voltinism patterns (univoltine vs. multivoltine, respectively) of O. nubilalis: southern multivoltine populations have opportunities for multiple matings for the duration of the year, further mix alleles. AMOVA results also indicated that most of the genetic variation was within sub-populations (≈ 81% of total variation); less variation (≈ 13%) was detected among populations within each of the three regions as designated for this study. However, the most striking and unexpected result was the low percentage of variation between all groups (≈ 6%), further supporting implications of a high degree of gene flow. These results provide support for current requirements of refugia corn planting in Bt-corn management. These results also indicate that if resistance to Bt were to evolve in O. nubilalis, quick action would be necessary to deter the rapid spread of the gene for resistance.
One touch multi-banking transaction ATM system using biometric and GSM authentication

Every individuals has multiple bank accounts in different banks, people's need to carry multiple ATM cards for transaction, there may be different PINs for every account. In traditional system, ATM terminal customer recognition systems only rely on bank cards, security pin number, and such identity verification methods which measures are not perfect and functions are too single and at times there are incidents where we forget ours security PIN number, lose our cards, cards get stolen, stolen PIN numbers. To overcome the bugs in traditional ATM system, introducing a new ATM terminal customer recognition system, “One touch Multi-banking Transaction system using Biometric and GSM Authentication”. Biometric based fingerprint authentication technique is one of the most secure systems, unauthorized accesses are restricted, as this makes fingerprint a unique identification for everyone. This system also assures a secure GSM (OTP-One time Password) based transaction. Here the proposed system has no risk overhead in managing multiple account transactions and achieves high security as compare to the traditional ATM system.
Empathy and moral emotions in post-apartheid South Africa: an fMRI investigation

Abstract Moral emotions elicited in response to others’ suffering are mediated by empathy and affect how we respond to their pain. South Africa provides a unique opportunity to study group processes given its racially divided past. The present study seeks insights into aspects of the moral brain by investigating behavioral and functional MRI responses of White and Black South Africans who lived through apartheid to in- and out-group physical and social pain. Whereas the physical pain task featured faces expressing dynamic suffering, the social pain task featured victims of apartheid violence from the South African Truth and Reconciliation Commission to elicit heartfelt emotion. Black participants’ behavioral responses were suggestive of in-group favoritism, whereas White participants’ responses were apparently egalitarian. However, all participants showed significant in-group biases in activation in the amygdala (physical pain), as well as areas involved in mental state representation, including the precuneus, temporoparietal junction (TPJ) and frontal pole (physical and social pain). Additionally, Black participants reacted with heightened moral indignation to own-race suffering, whereas White participants reacted with heightened shame to Black suffering, which was associated with blunted neural empathic responding. These findings provide ecologically valid insights into some behavioral and brain processes involved in complex moral situations.
MC2ESVM: Multiclass Classification Based on Cooperative Evolution of Support Vector Machines

Support vector machines (SVMs) are one of the most powerful learning algorithms for solving classification problems. However, in their original formulation, they only deal with binary classification. Traditional extensions of the binary SVMs for multiclass problems are based either on decomposing the problem into a number of binary classification problems, which are then independently solved, or on reformulating the objective function by solving larger optimization problems. In this paper, we propose MC<sup>2</sup>ESVM, an approach for multiclass classification based on the cooperative evolution of SVMs. Cooperative evolution allows us to decompose an M-class problem into M subproblems, which are simultaneously optimized in a cooperative fashion. We have reformulated the optimization problem such that it focuses on learning the support vectors for each class at the time that it takes into account the information from other classes. A comprehensive experimental study using common benchmark datasets is carried out to validate MC<sup>2</sup>ESVM. The experimental results, supported by statistical tests, show the effectiveness of MC<sup>2</sup>ESVM for solving multiclass classification problems, while keeping a reasonable number of support vectors.
Psychometric characteristics of the Muslim Religiosity Scale in Iranian patients with cancer

Abstract Objective: Cancer is a leading cause of death worldwide. Religiosity is a factor that may help cancer patients to cope with their disease. The aim of the current study was to validate a Persian translation of the Muslim Religiosity Scale (MRS) in a population of Iranian patients with cancer. Method: Two thousand patients were invited to participate in this multisite study, of whom 1,879 participated. Patients completed a demographic questionnaire, the MRS, and several scales, including the Patient Health Questionnaire–9, the Hospital Anxiety and Depression Scale, the Perceived Social Support Scale, and the SF–12 quality of life measure. Backward–forward translation was employed to develop a Persian-language version of the MRS. Cronbach's alpha and two-week test–retest reliability were also assessed. Convergent and discriminative validity as well as the factor structure of the scale were also examined. Results: The internal reliability (α) of the religious practices and beliefs subscales was 0.88 and 0.92, respectively. The intraclass correlation coefficient (ICC) was 0.92 (range = 0.75–1.0). The scale demonstrated solid convergent and discriminative validity. Factor analysis indicated two main factors, as predicted, with an appropriate goodness of fit (χ2 = 76.23, RMSEA = 0.065). Such factors as marital status, quality of life, social support, and self-efficacy were positively associated with MRS total score, while anxiety, depression, and suicide ideation had negative associations. Significance of results: The MRS is a useful tool for assessing religiosity in Iranian patients with cancer and is associated with a number of important health outcomes.
Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

The promise of drug repurposing is that existing drugs may be used for new disease indications in order to curb the high costs and time for approval. The goal of computational methods for drug repurposing is to enable solutions for safer, cheaper and faster drug discovery. Towards this end, we developed a novel method that integrates genetic and clinical phenotype data from large-scale GWAS and PheWAS studies with detailed drug information on the concept of transitive Drug-Gene-Disease triads. We created "RE:fine Drugs," a freely available, interactive dashboard that automates gene, disease and drug-based searches to identify drug repurposing candidates. This web-based tool supports a user-friendly interface that includes an array of advanced search and export options. Results can be prioritized in a variety of ways, including but not limited to, biomedical literature support, strength and statistical significance of GWAS and/or PheWAS associations, disease indications and molecular drug targets. Here we provide a protocol that illustrates the functionalities available in the "RE:fine Drugs" system and explores the different advanced options through a case study.
Mastering the Dungeon: Grounded Language Learning by Mechanical Turker Descent

Contrary to most natural language processing research, which makes use of static datasets, humans learn language interactively, grounded in an environment. In this work we propose an interactive learning procedure called Mechanical Turker Descent (MTD) and use it to train agents to execute natural language commands grounded in a fantasy text adventure game. In MTD, Turkers compete to train better agents in the short term, and collaborate by sharing their agents' skills in the long term. This results in a gamified, engaging experience for the Turkers and a better quality teaching signal for the agents compared to static datasets, as the Turkers naturally adapt the training data to the agent's abilities.
Mitotic spindle assembly and γ-tubulin localisation depend on the integral nuclear membrane protein Samp1

ABSTRACT We have investigated a possible role for the inner nuclear membrane protein Samp1 (also known as TMEM201) in the mitotic machinery. Live-cell imaging showed that Samp1a–YFP (Samp1a is the short isoform of Samp1) distributed as filamentous structures in the mitotic spindle, partially colocalising with β-tubulin. Samp1 depletion resulted in an increased frequency of cells with signs of chromosomal mis-segregation and prolonged metaphase, indicating problems with spindle assembly and/or chromosomal alignment. Consistent with this, mitotic spindles in Samp1-depleted cells contained significantly lower levels of β-tubulin and γ-tubulin, phenotypes that were rescued by overexpression of Samp1a–YFP. We found that Samp1 can bind directly to γ-tubulin and that Samp1 co-precipitated with γ-tubulin and the HAUS6 subunit of the Augmin complex in live cells. The levels of HAUS6, in the mitotic spindle also decreased after Samp1 depletion. We show that Samp1 is involved in the recruitment of HAUS6 and γ-tubulin to the mitotic spindle. Samp1 is the first inner nuclear membrane protein shown to have a function in mitotic spindle assembly. Highlighted Article: The transmembrane inner nuclear membrane protein Samp1 has a functional role in recruitment of γ-tubulin to the mitotic spindle and correct spindle assembly.
The future is today: emerging drugs for the treatment of erectile dysfunction

Importance of the field: Erectile dysfunction (ED) is the most common male sexual dysfunction presented for treatment affecting between 10 and 20% of men. PDE type 5 inhibitors (PDE5I) now account for the largest segment of the ED market. While these drugs are highly efficacious for many men, a relatively large subset of ED patients who do not respond to PDE5I is increasingly recognized. Areas covered in this review: In this review, we discuss clinical and preclinical evidence supporting various emerging compounds that regulate penile erection both centrally (clavulanic acid, dopamine and melanocortin receptor agonists) and peripherally (novel PDE5I, soluble and particulate guanylil cyclase activators, rho-kinase inhibitors and maxi-K channel openers). What the reader will gain: The reader will gain a broad understanding of erectile (patho-)physiology and gain insights in the mechanisms of action, efficacy and adverse events of various compounds under development for the treatment of ED. Take home message: We expect emerging drugs to allow treatment protocols tailored to the specific needs of each individual patient, taking into consideration the efficacy of erectile performance enhancement and the potential for adverse events. This tailored approach may include combination of various emerging drugs to enhance efficacy in difficult-to-treat patients.
Development of synaptic networks in the mouse vagal pathway revealed by optical mapping with a voltage‐sensitive dye

The central issue in developmental neuroscience is when and how neural synaptic networks are established and become functional within the central nervous system (CNS). Investigations of the neural network organization have been hampered because conventional electrophysiological means have some technical limitations. In this study, the multiple‐site optical recording technique with a voltage‐sensitive dye was employed to survey the developmental organization of the vagal system in the mouse embryo. Stimulation of the vagus nerve in E11–E14 mouse embryos elicited optical responses in areas corresponding to the vagal sensory and motor nuclei. Postsynaptic responses in the first‐order sensory nucleus, the nucleus of the tractus solitarius (NTS), were identified from E11, suggesting that sensory information becomes transferred to the brain at this stage. In addition to the NTS, optical responses were identified in the rostral and contralateral brainstem regions, which corresponded to second/higher order nuclei of the vagus nerve including the parabrachial nucleus (PBN). Postsynaptic responses in the second/higher‐order nuclei were detected from E12, suggesting that polysynaptic networks were functional at this stage. We discuss the results of our optical mapping, comparing them with previous findings obtained in the chick and rat embryos, and suggest some fundamental principles in the functional organization of synaptic networks in the embryonic brain.
Asynchronous warming and δ18O evolution of deep Atlantic water masses during the last deglaciation

Significance The reorganizations of deep Atlantic water masses are widely thought to regulate glacial–interglacial climate changes. However, the pattern of reorganizations and their impact on ocean tracer transport remain poorly constrained by marine proxies. Our modeling study, which simulates the coevolution of water masses and oxygen isotopes during the last deglaciation, suggests that deglacial meltwater input causes both northern- and southern-sourced deep water transports to decrease. This reorganization pattern leads to asynchronous warming between the deep North and South Atlantic, which might have caused the observed deglacial phasing difference in deep water oxygen isotope records between these ocean basins. We further propose a mechanism to explain the early warming in the northern North Atlantic. The large-scale reorganization of deep ocean circulation in the Atlantic involving changes in North Atlantic Deep Water (NADW) and Antarctic Bottom Water (AABW) played a critical role in regulating hemispheric and global climate during the last deglaciation. However, changes in the relative contributions of NADW and AABW and their properties are poorly constrained by marine records, including δ18O of benthic foraminiferal calcite (δ18Oc). Here, we use an isotope-enabled ocean general circulation model with realistic geometry and forcing conditions to simulate the deglacial water mass and δ18O evolution. Model results suggest that, in response to North Atlantic freshwater forcing during the early phase of the last deglaciation, NADW nearly collapses, while AABW mildly weakens. Rather than reflecting changes in NADW or AABW properties caused by freshwater input as suggested previously, the observed phasing difference of deep δ18Oc likely reflects early warming of the deep northern North Atlantic by ∼1.4 °C, while deep Southern Ocean temperature remains largely unchanged. We propose a thermodynamic mechanism to explain the early warming in the North Atlantic, featuring a strong middepth warming and enhanced downward heat flux via vertical mixing. Our results emphasize that the way that ocean circulation affects heat, a dynamic tracer, is considerably different from how it affects passive tracers, like δ18O, and call for caution when inferring water mass changes from δ18Oc records while assuming uniform changes in deep temperatures.
Phase Angle of Entrainment in Morning‐ and Evening‐Types under Naturalistic Conditions

Differences in morningness‐eveningness among humans are commonly ascribed to circadian parameters, such as circadian period and responsivity to environmental time cues, as well as homeostatic sleep drive. Light is the primary synchronizer of the human biological clock, and if circadian differences exist between morning and evening types, they should have different phase angles of entrainment to the light/dark cycle; that is, morning and evening types should have different patterns of light exposure relative to endogenous circadian phase (ECP). When phase angle of entrainment is strictly defined as the relationship between a marker of ECP and the timing of light exposure, such differences have been demonstrated in the laboratory under controlled light/dark cycles and have recently been shown under conditions of spring and summer light exposure outside the laboratory, taking into account the variable intensity of light. Here, we report similar results from a large (n=66), diverse cohort of morning and evening types across the age span studied at all different times of the year. Differences between morning and evening types in light exposure relative to ECP, indicative of a difference in the phase angle of entrainment to the external light/dark cycle, were found. Specifically, evening types, compared to morning types, had a higher ratio of phase advancing to phase delaying by light. We interpret this as indicating a longer circadian period (τ) in evening types.
When less is more: validating a brief scale to rate interprofessional team competencies

ABSTRACT Background: There is a need for validated and easy-to-apply behavior-based tools for assessing interprofessional team competencies in clinical settings. The seven-item observer-based Modified McMaster-Ottawa scale was developed for the Team Objective Structured Clinical Encounter (TOSCE) to assess individual and team performance in interprofessional patient encounters. Objective: We aimed to improve scale usability for clinical settings by reducing item numbers while maintaining generalizability; and to explore the minimum number of observed cases required to achieve modest generalizability for giving feedback. Design: We administered a two-station TOSCE in April 2016 to 63 students split into 16 newly-formed teams, each consisting of four professions. The stations were of similar difficulty. We trained sixteen faculty to rate two teams each. We examined individual and team performance scores using generalizability (G) theory and principal component analysis (PCA). Results: The seven-item scale shows modest generalizability (.75) with individual scores. PCA revealed multicollinearity and singularity among scale items and we identified three potential items for removal. Reducing items for individual scores from seven to four (measuring Collaboration, Roles, Patient/Family-centeredness, and Conflict Management) changed scale generalizability from . 75 to . 73. Performance assessment with two cases is associated with reasonable generalizability (.73). Students in newly-formed interprofessional teams show a learning curve after one patient encounter. Team scores from a two-station TOSCE demonstrate low generalizability whether the scale consisted of four (.53) or seven items (.55). Conclusion: The four-item Modified McMaster-Ottawa scale for assessing individual performance in interprofessional teams retains the generalizability and validity of the seven-item scale. Observation of students in teams interacting with two different patients provides reasonably reliable ratings for giving feedback. The four-item scale has potential for assessing individual student skills and the impact of IPE curricula in clinical practice settings. Abbreviations: IPE: Interprofessional education; SP: Standardized patient; TOSCE: Team objective structured clinical encounter