Miracle-dz/UniFAR-FTUs huggingface dataset:
Porcine Isolated Liver Perfusion for the Study of Ischemia Reperfusion Injury: A Systematic Review

Background Understanding ischemia reperfusion injury (IRI) is essential to further improve outcomes after liver transplantation (LT). Porcine isolated liver perfusion (ILP) is increasingly used to reproduce LT-associated IRI in a strictly controlled environment. However, whether ILP is a reliable substitute of LT was never validated. Methods We systematically reviewed the current experimental setups for ILP and parameters of interest reflecting IRI. Results Isolated liver perfusion was never compared with transplantation in animals. Considerable variability exists between setups, and comparative data are unavailable. Experience so far suggests that centrifugal pump(s) with continuous flow are preferred to reduce the risk of embolism. Hepatic outflow can be established by cannulation of the inferior vena cava or freely drained in an open bath. Whole blood at approximately 38°C, hematocrit of 20% or greater, and the presence of leukocytes to trigger inflammation is considered the optimal perfusate. A number of parameters related to the 4 liver compartments (hepatocyte, cholangiocyte, endothelium, immune cells) are available; however, their significance and relation to clinical outcomes is not well described. Conclusions Porcine ILP provides a reproducible model to study early IRI events. As all models, it has its limitations. A standardization of the setup would allow comparison of data and progress in the field.
Ultra-low-dose coronary artery calcium scoring using novel scoring thresholds for low tube voltage protocols—a pilot study

Aims To determine if tube-adapted thresholds for coronary artery calcium (CAC) scoring by computed tomography at 80 kilovolt-peak (kVp) tube voltage and 70-kVp yield comparable results to the standard 120-kVp protocol. Methods and results We prospectively included 103 patients who underwent standard scanning with 120-kVp tube voltage and additional scans with 80 kVp and 70 kVp. Mean body mass index (BMI) was 27.9 ± 5.1 kg/m2. For the lowered tube voltages, we applied novel kVp-adapted thresholds for calculation of CAC scores and compared them with standard 120-kVp scans using intraclass correlation and Bland-Altman (BA) analysis. Furthermore, risk-class (CAC score 0/1-10/11-100/101-400/>400) changes were assessed. Median CAC score from 120-kVp scans was 212 (interquartile range 25-901). Thirteen (12.6%) patients had zero CAC. Using the novel kVp-adapted thresholds, CAC scores derived from 80-kVp scans showed excellent correlation (r = 0.994, P < 0.001) with standard 120-kVp scans with BA limits of agreement of -235 (-39.5%) to 172 (28.9%). Similarly, for 70-kVp scans, correlation was excellent (r = 0.972, P < 0.001) but with broader limits of agreement of -476 (-85.0%) to 270 (48.2%). Only 2 (2.8%) reclassifications were observed for the 80-kVp scans in patients with a BMI <30 kg/m2 (n = 71), and 2 (6.1%) for the 70-kVp scans in patients with a BMI <25 kg/m2 (n = 33). Mean effective radiation dose was 0.60 ± 0.07 millisieverts (mSv), 0.19 ± 0.02 mSv, and 0.12 ± 0.01 mSv for the 120-kVp, 80-kVp, and 70-kVp scans, respectively. Conclusion The present study suggests that CAC scoring with reduced peak tube voltage is accurate if kVp-adapted thresholds for calculation of CAC scores are applied while offering a substantial further radiation dose reduction.
Short-distance matrix elements for D 0 -meson mixing from N f = 2 + 1 lattice QCD

We calculate in three-flavor lattice QCD the short-distance hadronic matrix elements of all five ΔC=2 four-fermion operators that contribute to neutral D-meson mixing both in and beyond the Standard Model. We use the MILC Collaboration’s Nf=2+1 lattice gauge-field configurations generated with asqtad-improved staggered sea quarks. We also employ the asqtad action for the valence light quarks and use the clover action with the Fermilab interpretation for the charm quark. We analyze a large set of ensembles with pions as light as lattice gauge-field configurations generated with asqtad-improved staggered sea quarks. We also employ the asqtad action for the valence light quarks and use the clover action with the Fermilab interpretation for the charm quark. We analyze a large set of ensembles with pions as light as Mπ ≈ 180 MeV and lattice spacings as fine as a ≈ 0.045 fm, thereby enabling good control over the extrapolation to the physical pion mass and continuum limit. We obtain for the matrix elements in the MS−NDR scheme using the choice of evanescent operators proposed by Beneke et al., evaluated at 3 GeV, ⟨D0|Oi|¯D0⟩ = {0.0805(55)16),−0.1561(70)(31), 0.0464(31)(9), 0.2747(129)(55), 0.1035(71)(21)} GeV4 (i=1–5). The errors shown are from statistics and lattice systematics, and the omission of charmed sea quarks, respectively. To illustrate the utility of our matrix-element results, we place bounds on the scale of CP-violating new physics in D0 mixing, finding lower limits of about 10–50×103 TeV for couplings of O(1). To enable our results to be employed in more sophisticated or model-specific phenomenological studies, we provide the correlations among our matrix-element results. For convenience, we also present numerical results in the other commonly used scheme of Buras, Misiak, and Urban.
Damping Optimization of Viscoelastic Laminated Sandwich Structures using the Direct Multisearch Method

A multiobjective approach for optimization of passive damping for vibration reduction in sandwich structures is presented in this paper. A layerwise finite element model for sandwich plates with viscoelastic core and anisotropic laminated face layers is used along with the complex modulus approach and the dynamic problem is solved in the frequency domain. Constrained optimization is conducted for maximisation of modal loss factors and minimisation of weight of sandwich beams and plates with elastic laminated constraining layers and a viscoelastic core, with layer thickness and laminate layer ply orientation angles as design variables. The problem is solved using the Direct MultiSearch (DMS) solver for derivative-free multiobjective optimization and solutions are compared with alternative ones obtained using genetic algorithms. DMS is a solver for multiobjective optimization problems whichdoes not use any derivatives of the objective functions. It is based on a novel technique called direct multisearch, developed by extending direct search from single to multiobjective optimisation.
Quality and Usability of Arthritic Pain Self-Management Apps for Older Adults: A Systematic Review

Objective To appraise the quality and usability of currently available pain applications that could be used by community-dwelling older adults to self-manage their arthritic pain. Methods A systematic review. Searches were conducted in App Store and Google Play to identify pain self-management apps relevant to arthritic pain management. English language pain management apps providing pain assessment and documentation function and pain management education were considered for inclusion. A quality evaluation audit tool based on the Stanford Arthritis Self-Management Program was developed a priori to evaluate app content quality. The usability of included apps was assessed using an established usability evaluation tool. Results Out of the 373 apps that were identified, four met the inclusion criteria. The included apps all included a pain assessment and documentation function and instructions on medication use, communication with health professionals, cognitive behavioral therapy-based pain management, and physical exercise. Management of mood, depression, anxiety, and sleep were featured in most apps (N = 3). Three-quarters (N = 3) of the apps fell below the acceptable moderate usability score (≥3), while one app obtained a moderate score (3.2). Conclusions Few of the currently available pain apps offer a comprehensive pain self-management approach incorporating evidence-based strategies in accordance with the Stanford Arthritis Self-Management Program. The moderate-level usability across the included apps indicates a need to consider the usability needs of the older population in future pain self-management app development endeavors.
Large contribution of clonal reproduction to the distribution of deciduous liana species (Wisteria floribunda) in an old-growth cool temperate forest: evidence from genetic analysis

Background and Aims Extensive clonal (vegetative) reproduction in lianas is a common and important life history strategy for regeneration and colonization success. However, few studies have evaluated the contribution of clonal reproduction to stand-level distribution of lianas in their natural habitat using genetic tools. The objectives of the present study were to investigate (1) the contribution of clonal reproduction to the distribution of Wisteria floribunda, (2) the size of clonal patches and (3) how the distribution patterns of W. floribunda clones are affected by micro-topography. Methods The contribution of clonal reproduction to the distribution of the deciduous liana species W. floribunda was evaluated using genetic analysis across a 6-ha plot of an old-growth temperate forest in Japan and preference in landform between clonal ramets and non-clonal ramets was assessed. Key Results Of the 391 ramets sampled, clonal reproduction contributed to 71 and 62 % of the total abundance and basal area, respectively, or 57 and 31 % when the largest ramet within a genet was excluded. The large contribution of clonal reproduction to the density and basal area of W. floribunda was consistent with previous observational studies. The largest genet included a patch size of 0.47 ha and ranged over 180 m. Preferred landforms of clonal and non-clonal ramets were significantly different when evaluated by both abundance and basal area. Non-clonal ramets distributed more on lower part of the slope than other landforms in comparison with clonal ramets and trees, possibly reflecting the limitation of clonal growth by stolons. Conclusions Using genetic analysis, the present study found evidence of a large contribution of clonal reproduction on the distribution of W. floribunda in its natural habitat. The results indicate that clonal reproduction plays an important role not only in the formation of populations but also in determining the distribution patterns of liana species.
Neuronal Subtype Generation During Postnatal Olfactory Bulb Neurogenesis

In the perinatal and adult forebrain, regionalized neural stem cells lining the ventricular walls produce different types of olfactory bulb interneurons. Although these postnatal stem cells are lineage related to their embryonic counterparts that produce, for example, cortical, septal, and striatal neurons, their output at the level of neuronal phenotype changes dramatically. Tiveron et al. investigated the molecular determinants underlying stem cell regionalization and the gene expression changes inducing the shift from embryonic to adult neuron production. High-resolution gene expression analyses of different lineages revealed that the zinc finger proteins, Zic1 and Zic2, are postnatally induced in the dorsal olfactory bulb neuron lineage. Functional studies demonstrated that these factors confer a GABAergic and calretinin-positive phenotype to neural stem cells while repressing dopaminergic fate. Based on these findings, we discuss the molecular mechanisms that allow acquisition of new traits during the transition from embryonic to adult neurogenesis. We focus on the involvement of epigenetic marks and emphasize why the identification of master transcription factors, that instruct the fate of postnatally generated neurons, can help in deciphering the mechanisms driving fate transition from embryonic to adult neuron production.
Hybrid Storage Management for Database Systems

The use of flash-based solid state drives (SSDs) in storage systems is growing. Adding SSDs to a storage system not only raises the question of how to manage the SSDs, but also raises the question of whether current buffer pool algorithms will still work effectively. We are interested in the use of hybrid storage systems, consisting of SSDs and hard disk drives (HDDs), for database management. We present cost-aware replacement algorithms, which are aware of the difference in performance between SSDs and HDDs, for both the DBMS buffer pool and the SSDs. In hybrid storage systems, the physical access pattern to the SSDs depends on the management of the DBMS buffer pool. We studied the impact of buffer pool caching policies on SSD access patterns. Based on these studies, we designed a cost-adjusted caching policy to effectively manage the SSD. We implemented these algorithms in MySQL's InnoDB storage engine and used the TPC-C workload to demonstrate that these cost-aware algorithms outperform previous algorithms.
ExpandNet: A Deep Convolutional Neural Network for High Dynamic Range Expansion from Low Dynamic Range Content

High dynamic range (HDR) imaging provides the capability of handling real world lighting as opposed to the traditional low dynamic range (LDR) which struggles to accurately represent images with higher dynamic range. However, most imaging content is still available only in LDR. This paper presents a method for generating HDR content from LDR content based on deep Convolutional Neural Networks (CNNs) termed ExpandNet. ExpandNet accepts LDR images as input and generates images with an expanded range in an end‐to‐end fashion. The model attempts to reconstruct missing information that was lost from the original signal due to quantization, clipping, tone mapping or gamma correction. The added information is reconstructed from learned features, as the network is trained in a supervised fashion using a dataset of HDR images. The approach is fully automatic and data driven; it does not require any heuristics or human expertise. ExpandNet uses a multiscale architecture which avoids the use of upsampling layers to improve image quality. The method performs well compared to expansion/inverse tone mapping operators quantitatively on multiple metrics, even for badly exposed inputs.
Measuring Interaction Proxemics with Wearable Light Tags

The proxemics of social interactions (e.g., body distance, relative orientation) influences many aspects of our everyday life: from patients' reactions to interaction with physicians, successes in job interviews, to effective teamwork. Traditionally, interaction proxemics has been studied via questionnaires and participant observations, imposing high burden on users, low scalability and precision, and often biases. In this paper we present Protractor, a novel wearable technology for measuring interaction proxemics as part of non-verbal behavior cues with fine granularity. Protractor employs near-infrared light to monitor both the distance and relative body orientation of interacting users. We leverage the characteristics of near-infrared light (i.e., line-of-sight propagation) to accurately and reliably identify interactions; a pair of collocated photodiodes aid the inference of relative interaction angle and distance. We achieve robustness against temporary blockage of the light channel (e.g., by the user's hand or clothes) by designing sensor fusion algorithms that exploit inertial sensors to obviate the absence of light tracking results. We fabricated Protractor tags and conducted real-world experiments. Results show its accuracy in tracking body distances and relative angles. The framework achieves less than 6° error 95% of the time for measuring relative body orientation and 2.3-cm - 4.9-cm mean error in estimating interaction distance. We deployed Protractor tags to track user's non-verbal behaviors when conducting collaborative group tasks. Results with 64 participants show that distance and angle data from Protractor tags can help assess individual's task role with 84.9% accuracy, and identify task timeline with 93.2% accuracy.
Viewpoint: Reversible nature of platelet binding causing transfusion-related acute lung injury (TRALI) syndrome may explain dyspnea after ticagrelor and elinogrel

Summary There may be a universal mechanism explaining dyspnea after ticagrelor and elinogrel, namely, transfusion-related acute lung injury (TRALI). Indeed, recent clinical trials with ticagrelor (DISPERSE, DISPERSE-II, and PLATO), and elinogrel (INNOVATE PCI) revealed double-digit rates of dyspnea after novel reversible antiplatelet agents. In contrast, dyspnea is not associated with conventional non-reversible agents such as aspirin, or thienopyridines (ticlopidine, clopidogrel, or prasugrel) suggesting distinct mechanism of shortness of breath after ticagrelor and elinogrel. The adenosine hypothesis has been offered to explain such adverse association. However, despite obvious similarity between ticagrelor and adenosine molecules, the chemical structure of elinogrel is entirely different. In fact, ticagrelor is a cyclopentyl-triazolo-pyrimidine, while elinogrel is a quinazolinedione. Since both agents cause dyspnea, the adenosine hypothesis is no longer valid. In contrast, the reversible nature of platelet inhibition attributable to both ticagrelor and elinogrel causing premature cell ageing, apoptosis, impaired turnover due to sequestration of overloaded, exhausted platelets in the pulmonary circulation are among potential autoimmune mechanism(s) resulting in the development of a TRALI-like reaction, and frequent dyspnea. Despite expected benefit for better bleeding control, further development of reversible antithrombins is severely limited due to the existence of a potentially universal serious adverse event, such as TRALI-syndrome with dyspnea as a predominant clinical manifestation. Since TRALI is an established number one contributor to mortality after blood transfusions, ticagrelor death “benefit”in PLATO is challenged further.
Encoding novel face‐name associations: A functional MRI study

The process of forming new associations between previously unrelated items of information, such as a name and a face, likely requires the integration of activity within multiple brain regions. The hippocampus and related structures in the medial temporal lobe are thought to be particularly critical in binding together items of information. We studied eight healthy young subjects with functional magnetic resonance imaging (fMRI) during the encoding of novel face‐name associations compared to viewing repeated face‐name pairs. A consistent pattern of activation was observed in the hippocampus, pulvinar nucleus of the thalamus, fusiform and dorsolateral prefrontal cortices across individual subjects. The location of the activation within the hippocampus was more anterior than previously reported in studies using similar novel vs. repeated paradigms with stimuli that did not specifically require relational processing among unrelated items. These data suggest that the process of forming new face‐name associations is supported by a distributed network of brain regions, and provide additional evidence for the essential role of the hippocampus in associative memory processes. Hum. Brain Mapping 14:129–139, 2001. © 2001 Wiley‐Liss, Inc.
Bone Mineral Density and Risk of Heart Failure in Older Adults: The Cardiovascular Health Study

Background Despite increasing evidence of a common link between bone and heart health, the relationship between bone mineral density (BMD) and heart failure (HF) risk remains insufficiently studied. Methods and Results We investigated whether BMD measured by dual‐energy x‐ray absorptiometry was associated with incident HF in an older cohort. Cox models were stratified by sex and interactions of BMD with race assessed. BMD was examined at the total hip and femoral neck separately, both continuously and by World Health Organization categories. Of 1250 participants, 442 (55% women) developed HF during the median follow‐up of 10.5 years. In both black and nonblack women, neither total hip nor femoral neck BMD was significantly associated with HF; there was no significant interaction by race. In black and nonblack men, total hip, but not femoral neck, BMD was significantly associated with HF, with evidence of an interaction by race. In nonblack men, lower total hip BMD was associated with higher HF risk (hazard ratio, 1.13 [95% CI, 1.01–1.26] per 0.1 g/cm2 decrement), whereas in black men, lower total hip BMD was associated with lower HF risk (hazard ratio, 0.74 [95% CI, 0.59–0.94]). There were no black men with total hip osteoporosis. Among nonblack men, total hip osteoporosis was associated with higher HF risk (hazard ratio, 2.83 [95% CI, 1.39–5.74]) compared with normal BMD. Conclusions Among older adults, lower total hip BMD was associated with higher HF risk in nonblack men but lower risk in black men, with no evidence of an association in women. Further research is needed to replicate these findings and to study potential underlying pathways.
The effect of Antithrombin-III on routine hematological and biochemical parameters in an experimental animal model of skeletal muscle ischemia-reperfusion injury.

BACKGROUND Antithrombin III (AT-III) has been shown to attenuate the local and systemic harmful effects of skeletal muscle ischemia-reperfusion (I-R) injury. The aim of the present study was to monitor the fluctuation of routine hematological and biochemical parameters in an experimental animal model of tourniquet-induced skeletal muscle I-R injury and to investigate how these are influenced by the protective administration of AT-III. METHODS Sixty male Wistar rats were submitted to a 6-hour, tourniquet-induced, complete ischemia of the right hind-limb. Animals were divided into those receiving AT-III (dose, 250 IU/kg) 30 minutes before the reperfusion (group A, n=30) and those receiving placebo (group B, n =30). Another 10 animals were sham-operated (group C). White blood cell (WBC) and platelet (PLT) count, aspartate and alanine aminotransferases (AST and ALT), alkaline phosphatase (ALP), and γ-glutamyl transferase (γ-GT) were estimated in blood samples taken from the inferior vena cava at 3 different time points post-reperfusion (at baseline, at 30 minutes and at 4 hours) and groups A and B were compared using the Mann-Whitney U test. RESULTS There were no statistically significant differences between the AT-III and the placebo groups at 0, 30 minutes and 4 hours with regard to the WBC, ALT and γ-GT levels, however, there was a significant decrease of AST levels 4 hours post-reperfusion in the AT-III group compared to the placebo group (p=0.002). An increased PLT count and ALP levels 30 minutes post-reperfusion were also noted in the AT-III group compared to placebo (p<0.001; and p=0.001, respectively). CONCLUSIONS Of the routine hematological and biochemical parameters tested, AST was found to be significantly suppressed at 4 hours in the AT-III-treated animals, suggesting a possible beneficial effect of AT-III in mouse skeletal muscle I-R injury. The effect of AT-III on PLTs and ALP levels merits further investigation. Hippokratia 2014; 18 (3): 234-239.