Miracle-dz/UniFAR-FTUs huggingface dataset:
Periodontal regeneration around natural teeth.

: 1. Evidence is conclusive (Table 2) that periodontal regeneration in humans is possible following the use of bone grafts, guided tissue regeneration procedures, both without and in combination with bone grafts, and root demineralization procedures. 2. Clinically guided tissue regeneration procedures have demonstrated significant positive clinical change beyond that achieved with debridement alone in treating mandibular and maxillary (buccal only) Class II furcations. Similar data exist for intraosseous defects. Evidence suggests that the use of bone grafts or GTR procedures produce equal clinical benefit in treating intraosseous defects. Further research is necessary to evaluate GTR procedures compared to, or combined with, bone grafts in treating intraosseous defects. 3. Although there are some data suggesting hopeful results in Class II furcations, the clinical advantage of procedures combining present regenerative techniques remains to be demonstrated. Additional randomized controlled trials with sufficient power are needed to demonstrate the potential usefulness of these techniques. 4. Outcomes following regenerative attempts remain somewhat variable with differences in results between studies and individual subjects. Some of this variability is likely patient related in terms of compliance with plaque control and maintenance procedures, as well as personal habits; e.g., smoking. Variations in the defects selected for study may also affect predictability of outcomes along with other factors. 5. There is evidence to suggest that present regenerative techniques lead to significant amounts of regeneration at localized sites on specific teeth. However, if complete regeneration is to become a reality, additional stimuli to enhance the regenerative process are likely needed. Perhaps this will be accomplished in the future, with combined procedures that include appropriate polypeptide growth factors or tissue factors to provide additional stimulus.
Traits that Define the Different Alcohol Intensive Consume Type during the Practice of “Botellon”

There is a phenomenon contributing to the current pattern of alcohol consumption among youngsters in Spain known as “botellon”. From research financed by the National Plan on Drugs (2004-2007), data of 6009 youngsters (14-25 years old) were collected from three Spanish cities. Only individuals who engage in intensive consumption of alcohol (n = 2807) have been included. The purpose of this work has been to identify the different types of consumers at risk through a cluster analysis and to establish a profile for each particular group. Four groups were differentiated by age, gender, alcohol consumption and years of consumption. It was observed that adolescent students and university students of the same sex consume similar quantities of alcohol, and justify their consumption alluding to personal factors, whereas university students refer to issues related to control of leisure. The consumption by males is the highest, and they are the most likely to seek drunkenness. They associate to a lesser degree their consumption with the possibility of developing an addictive process. In general, all youngsters consider that their consumption will have no negative consequences. These results indicate the need to come up with different alternatives, addressing the particularities of each group. Un fenómeno que en España favorece el actual patrón de consumo de alcohol juvenil es el conocido como botellón. A partir de una investigación financiada por el Plan Nacional sobre Drogas (2004-2007), se recogieron datos de 6009 jóvenes entre 14 y 25 años en tres ciudades españolas, considerando para este trabajo a quienes realizan episodios de consumo intensivo de alcohol (n = 2807). El objetivo ha sido identificar los distintos tipos de consumidores de riesgo intensivos mediante un análisis de conglomerados y establecer el perfil característico de cada uno. Se diferencian cuatro grupos en función de la edad, sexo, cantidad de alcohol y años de consumo. Los estudiantes de secundaria ingieren cantidades de alcohol similares a las de los universitarios de su mismo sexo y aluden a aspectos personales para justificar este consumo, mientras que los universitarios hacen referencia a cuestiones asociadas al control del ocio. Los varones son quienes más consumen y más buscan la borrachera, aunque asocian en menor grado su ingesta con la posibilidad de desarrollar un proceso adictivo. En general, todos los jóvenes consideran que su consumo no tendrá consecuencias negativas. Estos resultados indican la necesidad de proponer alternativas diferentes atendiendo a las peculiaridades de cada grupo.
icromachined rate gyroscope architecture with ultra-high quality factor and mproved mode ordering

This paper reports a new dual mass vibratory MEMS z-axis rate gyroscope architecture that prioritizes the sense-mode quality factor and provides improved ordering of the mechanical vibrational modes. The proposed linearly coupled, dynamically balanced anti-phase sense-mode design minimizes substrate energy dissipation to maximize the quality factor. The levered drive-mode mechanism structurally forces the
Ovarian Surface Epithelial Neoplasms in the Pediatric Population: Incidence, Histologic Subtype, and Natural History

Surface epithelial neoplasms account for a small but significant proportion of pediatric ovarian tumors. The overall incidence, prevalence of histologic subtypes, and natural history of these neoplasms has not been thoroughly evaluated. A retrospective review of the pathology archives of Stanford University School of Medicine yielded 69 surface epithelial ovarian tumors in 64 pediatric patients 18 years of age or younger from 1974 to 2010. Tumors comprised benign (57.8%), borderline/low malignant potential (LMP) (37.5%), and malignant (4.7%) subgroups and exhibited serous, mucinous, and mixed histology; there were no clear cell, pure endometrioid, or transitional (Brenner) tumors. In addition, no high-grade carcinomas were identified. Clinical follow-up data were available in a subset of patients (maximum follow-up, 22 y). Similar numbers of recurrences were found in each of the 3 subgroups. However, overall survival was 100% for benign and borderline/LMP tumors and 50% for carcinomas. The type of surgical management and the use of chemotherapy varied; 2 patients with borderline/LMP tumors were treated by sterilizing procedures and/or chemotherapy. These data suggest that surface epithelial neoplasms comprise a small but significant proportion of ovarian tumors in the pediatric population, and they exhibit a marked preponderance for benign, borderline, and low-grade malignant subgroups. In contrast to their adult counterpart, high-grade serous carcinoma in children is extraordinarily rare and not seen in this series. Given this difference, uniform treatment modalities with consideration for ovarian conservation and fertility preservation should be rigorously adopted in any pediatric patient with a suspected ovarian surface epithelial neoplasm.
Deforestation and the Rule of Law in a Cross-Section of Countries

Relationships between deforestation and population pressure, income growth, and insecure property rights are examined with data from 120 countries. Insecure property rights are hypothesized to arise from two sources: government instability or inability to enforce ownership and an absence of government accountability. The former source is captured by measures of general lawlessness such as guerrilla warfare, revolution, and frequent constitutional change. The latter is proxied by variables indicating the type of government executive, frequency of political purges, and the existence of an elected legislature. General support is indicated for the property rights hypothesis and for the effects of population growth.
CaPaMan (Cassino Parallel Manipulator) as sensored earthquake simulator

We report results of successful experiences using CaPaMan (Cassino Parallel Manipulator) as an earthquake simulator. The paper describes the experimental set up for a sensored mobile plate for verifying the numerical simulations with practical experiments. Reproducing accelerometer diagrams of actual earthquakes has proved a practical feasibility. Some numerical and experimental results are reported in the paper to show the interest for this application of CaPaMan.
Implementation of an IOT framework for smart healthcare

It is indeed a fast pace world today. People and technology are both growing at a speed that you can never think of. With work soon becoming priority to many individuals; we tend to neglect the most important factor that helps us survive and conquer the world, our own health. It has always said that Health is Wealth. However, in the recent years people have been spending most of their hard-earned money in Hospitals and medicines. Thus, it proves our negligence towards our health. Not only that, but also many people are moving abroad leaving their old parents in their hometowns and not being able to keep a track of the health of each other. With this thought in our minds, we decided to do something that will make it easier for people to keep a track of their loved one's health as well as their own. With the evolution of internet everything is possible on it, from finding information to tracking locations nearby. Internet has become a savior for the world today. Internet of Things is taking a step ahead in helping the world be even more connected. Therefore, we decided on making an IoT based Health Monitoring System. The whole concept of it is to help people keep a track of their health and allow doctors to reduce the use of paper and maintain a database of their patients on the internet.
The impact of e-business technologies on supply chain operations: a macroeconomic perspective

New information technologies and e-business solutions have transformed supply chain operations from mass production to mass customization. This paper assesses the impact of these innovations on economic productivity, focusing on the macroeconomic benefits as supply chain operations have evolved from simple production and planning systems to today's real-time performance-management information systems using advanced e-business technologies. While many factors can influence macroeconomic variables, the impact of IT-enabled supply chains should not be overlooked. We find evidence that the impact of e-business technologies on supply chain operations have resulted in a reduced "bullwhip effect," lower inventory, reduced logistics costs, and streamlined procurement processes. These improvements, in turn, have likely helped to lower inflation, reduce economic volatility, strengthen productivity growth, and improve standards of living.
Lipid Screening in Childhood and Adolescence for Detection of Multifactorial Dyslipidemia: Evidence Report and Systematic Review for the US Preventive Services Task Force.

IMPORTANCE Multifactorial dyslipidemia, characterized by elevated total cholesterol (TC) or low-density lipoprotein cholesterol (LDL-C), is associated with dyslipidemia and markers of atherosclerosis in young adulthood. Screening for dyslipidemia in childhood could delay or reduce cardiovascular events in adulthood. OBJECTIVE To systematically review the evidence on benefits and harms of screening adolescents and children for multifactorial dyslipidemia for the US Preventive Services Task Force (USPSTF). DATA SOURCES MEDLINE, Cochrane Central Register of Controlled Trials, and PubMed were searched for studies published between January 1, 2005, and June 2, 2015; studies included in a previous USPSTF evidence report and reference lists of relevant studies and ongoing trials were also searched. Surveillance was conducted through April 9, 2016. STUDY SELECTION Fair- and good-quality studies in English with participants 0 to 20 years of age. DATA EXTRACTION AND SYNTHESIS Two investigators independently reviewed abstracts and full-text articles and extracted data into evidence tables. Results were qualitatively summarized. MAIN OUTCOMES AND MEASURES Outcomes included dyslipidemia (TC≥200 mg/dL or LDL-C≥130 mg/dL) and atherosclerosis in childhood; myocardial infarction and ischemic stroke in adulthood; diagnostic yield (number of confirmed cases per children screened); and harms of screening or treatment. Simulated diagnostic yield was calculated as initial screening yield × positive predictive value from a study with confirmatory testing. RESULTS Screening of children for multifactorial dyslipidemia has not been evaluated in randomized clinical trials. Based on 1 observational study (n = 6500) and nationally representative prevalence estimates, the simulated diagnostic yield of screening for elevated TC varies between 4.8% and 12.3% (higher in obese children [12.3%] and at the ages when TC naturally peaks-7.2% at age 9-11 years and 7.2% at age 16-19 years). One good-quality randomized clinical trial (n = 663) found a modest effect of intensive dietary counseling for a low-fat, low-cholesterol diet on lipid levels at 1 year in children aged 8 to 10 years with mild to moderate dyslipidemia; mean between-group difference in TC change from baseline was -6.1 mg/dL (95% CI, -9.1 to -3.2 mg/dL; P < .001). Between-group differences dissipated by year 5. The intervention did not adversely affect nutritional status, growth, or development over the 18-year study period. One observational study (n = 9245) found that TC concentration at age 12 to 39 years was not associated with death before age 55 years. CONCLUSIONS AND RELEVANCE The diagnostic yield of lipid screening varies by age and body mass index. No direct evidence was identified for benefits or harms of childhood screening or treatment on outcomes in adulthood. Intensive dietary interventions may be safe, with modest short-term benefit of uncertain clinical significance.
Arsenic trioxide for management of acute promyelocytic leukemia: current evidence on its role in front-line therapy and recurrent disease

Introduction: Acute promyelocytic leukemia (APL), the most rapidly fatal leukemia only two decades ago, has been converted into the most frequently curable leukemia by the advent of all-trans retinoic acid (ATRA) and its combination with anthracycline-based chemotherapy. More recently, arsenic trioxide (ATO) has been shown to be the most effective single agent in this disease and has been approved for the treatment of relapsed patients both in the United States and Europe. Moreover, ATO has been included in the design of several front-line studies, with the aim to reduce therapy-related toxicity while maintaining the potential of cure. Areas covered: First, this review briefly discusses the mechanisms of action and the toxicity profile of ATO. Furthermore, the reported experience on the use of ATO as single agent or in combinatorial schemes both in relapsed and in newly diagnosed patients with APL is critically reviewed. Finally, the use of this agent in special subsets of patients unfit to receive conventional chemotherapy is discussed, along with its potential role in maintenance therapy. Expert opinion: While the role of ATO as single agent or in combination with ATRA is well established and recommended by the European LeukemiaNet guidelines as a first option for relapsed patients, the role of the drug in newly diagnosed patients is still uncertain and based only on evidence levels mostly originating from non-randomized trials. The results of ongoing randomized studies should better define the role of ATO in front-line therapy.
Risk of atrial fibrillation with high-dose corticosteroids

Atrial fibrillation (AF) is the most common sustained arrhythmia observed in clinical practice. Some drugs have been associated with the onset of AF, but knowledge about the role of drugs in the development of AF is scarce. High-dose corticosteroid therapy has been associated with the development of AF, but this is mainly based on case reports. Therefore, the authors review the available data in the international literature about the cause–effect relationship between corticosteroid therapy and the onset of AF.
Summer Meeting 2013: growth and physiology of bifidobacteria

Bifidobacteria are a minor fraction of the human colon microbiota with interesting properties for carbohydrate degradation. Monosaccharides such as glucose and fructose are degraded through the bifid shunt, a dedicated pathway involving phosphoketolase activity. Its stoechiometry learns that three moles of acetate and two moles of lactate are produced per two moles of glucose or fructose that are degraded. However, deviations from this 3 : 2 ratio occur, depending on the rate of substrate consumption. Slower growth rates favour the production of acetate and pyruvate catabolites (such as formate) at the cost of lactate. Interestingly, bifidobacteria are capable to degrade inulin‐type fructans (ITF) (oligofructose and inulin) and arabinoxylan‐oligosaccharides (AXOS). Beta‐fructofuranosidase activity enables bifidobacteria to degrade ITF. However, this property is strain‐dependent. Some strains consume both fructose and oligofructose, with different preferences and degradation rates. Small oligosaccharides (degree of polymerization or DP of 2–7) are taken up, in a sequential order, indicating intracellular degradation and as such giving these bacteria a competitive advantage towards other inulin‐type fructan degraders such as lactobacilli, bacteroides and roseburias. Other strains consume long fractions of oligofructose and inulin. Exceptionally, oligosaccharides with a DP of up to 20 (long‐chain inulin) are consumed by specific strains. Also, the degradation of AXOS by α‐arabinofuranosidase and β‐xylosidase is strain‐dependent. Particular strains consume the arabinose substituents, whether or not together with a consumption of the xylose backbones of AXOS, either up to xylotetraose or higher and either extra‐ or intracellularly. The production of high amounts of acetate that accompanies inulin‐type fructan degradation by bifidobacteria cross‐feeds other colon bacteria involved in the production of butyrate. However, bifidobacterial strain‐dependent differences in prebiotic degradation indicate the existence of niche‐specific adaptations and hence mechanisms to avoid competition among each other and to favour coexistence with other colon bacteria.
Differential Impact of Environmental Stresses on the Pea Mitochondrial Proteome*S

Exposure to adverse environmental conditions causes oxidative stress in many organisms, leading either to disease and debilitation or to response and tolerance. Mitochondria are a key site of oxidative stress and of cellular response and play important roles in cell survival. We analyzed the response of mitochondria in pea (Pisum sativum) plants to the common stresses associated with drought, cold, and herbicides. These treatments all altered photosynthetic and respiratory rates of pea leaves to various extents, but only herbicides significantly increased lipid peroxidation product accumulation. Mitochondria isolated from the stressed pea plants maintained their electron transport chain activity, but changes were evident in the abundance of uncoupling proteins, non-phosphorylating respiratory pathways, and oxidative modification of lipoic acid moieties on mitochondrial proteins. These data suggest that herbicide treatment placed a severe oxidative stress on mitochondria, whereas chilling and particularly drought were milder stresses. Detailed analysis of the soluble proteome of mitochondria by gel electrophoresis and mass spectrometry revealed differential degradation of key matrix enzymes during treatments with chilling being significantly more damaging than drought. Differential induction of heat shock proteins and specific losses of other proteins illustrated the diversity of response to these stresses at the protein level. Cross-species matching was required for mass spectrometry identification of nine proteins because only a limited number of pea cDNAs have been sequenced, and the full pea genome is not available. Blue-native separation of intact respiratory chain complexes revealed little if any change in response to environmental stresses. Together these data suggest that although many of the molecular events identified by chemical stresses of mitochondria from a range of model eukaryotes are also apparent during environmental stress of plants, their extent and significance can vary substantially.
Market Crowd Trading Conditioning and Its Measurement

In this paper, we study market crowd psychological behaviors in learning by correlation analysis, using every trading high frequency data in China stock market. We introduce a notion of trading conditioning in terms of operant conditioning in psychology and measure its intensity by accumulative trading volume probability in a time interval in the transaction price-volume probability wave equation that can describe market crowd coherence in their interacted trading behavior. We find that there is, in general, significant positive correlation between the rate of price volatility mean return and the change in the intensity of market crowd trading conditioning. They behave significantly disposition effect in stock selling and herd behavior in stock buying with expectation on return simultaneously. Specifically, “the herd” have significant stronger expectation on price momentum than its reversal. Second, there is also a significant negative correlation between them in a subdivided term; market crowd show buy-and-hold behavior when price rises steadily, and panic selling when it drops abruptly in depth. We explain both the puzzle of more peaked, heavily tailed, and clustered characteristics in return distribution by coherence and that of market crowd behavioral “anomalies” by trading conditioning in a unified transaction price-volume probability wave framework.
Endogenous Basic Protein Phosphatases in the Brain Myelin

Abstract: Direct treatment of brain myelin with freezing/thawing in 0.2 M2‐mercaptoethanol stimulated the endogenous myelin phosphatase activity manyfold when 32P‐la‐beled phosphorylase a was used as a substrate, a result indicating that an endogenous myelin phosphatase is a latent protein phosphatase. When myelin was treated with Triton X‐100, this endogenous latent phosphatase activity was further stimulated 2.5‐fold. Diethylaminoethyl‐cellulose and Sephadex G‐200 chromatography of solubilized myelin revealed a pronounced peak of protein phosphatase activity stimulated by freezing/thawing in 0.2 M2‐mercaptoethanol and with a molecular weight of 350, 000, which is characteristic of latent phosphatase 2, as previously reported. Moreover, endogenous phosphorylation of myelin basic protein (MBP) in brain myelin was completely reversed by a homogeneous preparation of exogenous latent phosphatase 2. By contrast, under the same conditions, endogenous phosphorylation of brain myelin was entirely unaffected by ATP. Mg‐dependent phosphatase and latent phosphatase 1, although both enzymes are potent MBP phosphatases. Together, these findings clearly indicate that a high‐molecular‐weight latent phosphatase, termed latent phosphatase 2, is the most predominant phosphatase responsible for dephosphorylation of brain myelin.