Miracle-dz/UniFAR-FTUs huggingface dataset:
Die Prävalenz von Sarkopenie bei Patienten mit rheumatischen Erkrankungen

bei der jetzigen Studiengröße war dieser Unterschied aber nicht signi ﬁ kant. Auch die Heterogenität der untersuchten Gruppen könnte eine Rolle spielen. Größere Patientenkohorten sind nötig, um die genauen Häu ﬁ gkeiten von SP bei einzelnen ERE zu untersuchen. Ein Screening auf SP kann anhand des 2018 EWGSOP-Algorithmus mit einfachen Methoden wie dem SARC-F-Fragebogen oder der Short Physical Performance Battery für SP durchgeführt werden. Der Einsatz dieser Instrumente im klinischen Alltag erscheint sinnvoll – vor allem, wenn daraus entsprechende Konsequenzen gezogen werden.
Similarity Coloring of DTI Fiber Tracts

We present a coloring method that conveys spatial relations between DTI fiber tracts effectively; similar tracts are assigned to similar colors and different tracts are assigned to different colors in a smooth and continuous manner. To this end, we combine a standard spectral approach with a mass-spring heuristic to embed fiber tracts into a perceptually uniform color space, L*a*b*. We also introduce a new geometric bivariate coloring model, the flat torus, that allows finer adjustment of coloring arbitrarily. Results indicate that our method allows a quick evaluation of tract projections and facilitate demarcation of subtle anatomical divisions in fiber tracts.
Amazon River enhances diazotrophy and carbon sequestration in the tropical North Atlantic Ocean

The fresh water discharged by large rivers such as the Amazon is transported hundreds to thousands of kilometers away from the coast by surface plumes. The nutrients delivered by these river plumes contribute to enhanced primary production in the ocean, and the sinking flux of this new production results in carbon sequestration. Here, we report that the Amazon River plume supports N2 fixation far from the mouth and provides important pathways for sequestration of atmospheric CO2 in the western tropical North Atlantic (WTNA). We calculate that the sinking of carbon fixed by diazotrophs in the plume sequesters 1.7 Tmol of C annually, in addition to the sequestration of 0.6 Tmol of C yr−1 of the new production supported by NO3 delivered by the river. These processes revise our current understanding that the tropical North Atlantic is a source of 2.5 Tmol of C to the atmosphere [Mikaloff-Fletcher SE, et al. (2007) Inverse estimates of the oceanic sources and sinks of natural CO2 and the implied oceanic carbon transport. Global Biogeochem Cycles 21, doi:10.1029/2006GB002751]. The enhancement of N2 fixation and consequent C sequestration by tropical rivers appears to be a global phenomenon that is likely to be influenced by anthropogenic activity and climate change.
Modeling of Silicon Carbide ECR Etching by Feed-Forward Neural Network and Its Physical Interpretations

The behavior of electron cyclotron resonance etching of 4H-SiC based on SF6 + O2 plasma is studied using a three-layered feed-forward neural network model trained by the Broyden, Fletcher, Goldfarb, and Shanno optimization algorithm. The etch rate of 4H-SiC is modeled as a function of microwave power, dc bias, process pressure, and O2/(SF6 + O2) flow ratio referred to as the O2 fraction. The results clearly reveal the interaction of the various process parameters and their resultant effects on the etch rate. It is found that, by varying the O2 fraction and process pressure, optimized etch rate peaks can be achieved. Increasing dc bias and microwave power is found to result in the optimized etch rate peaks occurring at higher O2 fraction and process pressure, respectively. In addition, increasing dc bias or microwave power will increase the etch rate. However, there is saturation in the etch rate at higher dc bias, which does not occur with microwave power. Based on these modeling results, detailed physical interpretations of the etching process are given in terms of the chemical reaction of 4H-SiC with F, O, positive ion bombardment, etc.
Recombinant human megakaryocyte growth and development factor increases levels of circulating haemopoietic progenitor cells post chemotherapy in patients with acute myeloid leukaemia

By participating in a randomized safety and efficacy study of pegylated‐recombinant human megakaryocyte growth and development factor (PEG‐rHuMGDF) post induction and consolidation chemotherapy for de novo acute myeloid leukaemia, serial determinations of circulating haemopoietic progenitor cells were performed during 18 chemotherapy courses in eight patients (three receiving placebo; one, 2.5; and four, 5.0 μg/kg/d MGDF, respectively). Whereas failure to achieve complete remission (CR) was generally associated with poor progenitor cell increments following chemotherapy, substantial progenitor cell mobilization consistently occurred during haemopoietic recovery in patients entering, or in CR, with significantly higher peak values in patients receiving 5 μg/kg/d of MGDF as compared to controls. The median increases of progenitor cell numbers by chemotherapy alone and chemotherapy plus 5.0 μg/kg/d MGDF over that in normal individuals with steady‐state haemopoiesis were 10‐ and 45‐fold for CFU‐GM, 3‐ and 17‐fold for BFU‐E, and 2‐ and 18‐fold for CFU‐mix. CFU‐Mk levels were not increased above normal by chemotherapy alone but were 15‐fold enhanced by chemotherapy plus MGDF. Recruitment of CD34+ cells post chemotherapy was also potentiated by MGDF. Our results suggest MGDF as a potent agent to augment progenitor cell mobilization after successful induction or consolidation chemotherapy in patients with AML.
Transcriptional dysregulation of the p73L / p63 / p51 / p40 / KET gene in human squamous cell carcinomas: expression of Δ Np73L, a novel dominant-negative isoform, and loss of expression of the potential tumour suppressor p51

We have recently identified a second p53 -related p73L gene, also referred to as p63/p51/p40/KET gene, which encodes the 2 major isoforms p73L and p51 resulting from different exon usage at their amino terminal regions. Although p73L and p51 are suspected to play oncogenic and tumour suppressive roles in mammalian cells, respectively, no evidence of linkage between the expression of these isoforms and human cancers has been reported so far. In this study, we first investigated the expression profile of p51 and p73L in various human tumour cell lines and found that a novel isoform, termed ΔNp73L, was predominantly expressed in squamous cell carcinomas. The expression profile of ΔNp73L/p73L/p51 in primary human skin cancer specimens showed that the expression of p51 was frequently lost (62%) but was detected in all normal skin samples. In p51-expressing skin cancers, ΔNp73L expression was associated at a high frequency (75%) though it was not detected in normal skin tissues. Transient co-transfection data indicate the possibility that ΔNp73L can inhibit p53-, and more preferentially, p51-mediated transactivation. These data suggest that the loss of expression of p51 and/or the expression of ΔNp73L might contribute to the pathogenesis of human squamous cell carcinomas. © 2001 Cancer Research Campaign http://www.bjcancer. com
Worse prognosis in breast cancer patients can be predicted by immunohistochemical analysis of positive MMP-2 and negative estrogen and progesterone receptors.

Introduction: Breast cancer is the most cause of death, and approximately 90% of these deaths are due to metastases. Matrix metalloproteinase-2 (MMP-2) gelatinase activity is able to degrade a major constituent of the tumor microenvironment, type IV collagen. Two well-established proteins used as markers in clinical practice for breast cancer are the receptors for estrogen (ER) and progesterone (PR). Although the presence of these receptors has been associated with a better prognosis, loss of these proteins can occur during tumor progression, with subsequent resistance to hormone therapy. Objective: To study the correlation among MMP-2, ER, and PR, as well as the establishment of the metastatic process in primary breast tumors. Method: Breast cancer samples (n=44) were analyzed by immunohistochemistry for MMP-2, ER, and PR. Results: We observed that 90% of patients who had metastases and died showed positive staining for MMP-2 (p=0.0082 for both). Using Kaplan-Meier analysis, we found that negative ER patients who were also positive for MMP-2 had even worse disease-free survival (DFS) and overall survival (OS) (p= 0.012 and p=0.005, respectively). Similar results were found in PR-negative patients for DFS (a trend p=0.077) and OS (p=0.038). Conclusion: Regardless of our small sample size (n=44), the data obtained strongly suggest that MMP-2 in combination with already well-established markers could help to predict the emergence of metastases and death in patients with breast cancer.
Feature Extraction for Image Super-resolution using Finite Rate of Innovation Principles

To understand a real-world scene from several multiview pictures, it is necessary to find the disparities existing between each pair of images so that they are correctly related to one another. , This process. called image registration, reguires the extraction of some specific information about the scene. This is achieved by taking features out of the acquired imaqes. Thus, the quality of the, registration depends largely on the accuracy of the extracted features. Feature extraction can be formulated as a sampling problem for which perfect reconstruction of the, desired features is wanted. The recent sampling theory for signals with finite rate of innovation (FR/), and the B-spline theory offer an appropriate new framework for the extraction of features in real, images. This thesis first focuses on extending the sampling theory for FRI signals to a multichannel, case and then presents exact sampling results for two different types of image features used for, registration: moments and edges. In the first part, it is shown that the geometric moments of an observed scene can be retrieved exactly from sampled images and used as global features for registration. The second part describes how edges can also be retrieved perfectly from sampled images for registration purposes. The proposed feature extraction schemes therefore allow in theory the exact registration of images. Indeed, various simulations show that the proposed extraction/registration methods overcome traditional ones, especially at low-resolution. These characteristics make such feature extraction techniques very appropriate for applications like image super-resolution for which a very precise registration is needed. The quality of the superresolved images obtained using the proposed feature extraction methods is improved by comparison with other approaches. Finally, the notion of polyphase components is used to adapt the imaqe acquisition model to the characteristics of real digital cameras in order to run super-resolution experiments on real images.
Compact torque sensor for a robot hand

For a robot to grasp and manipulate an object with a multi-fingered hand, not only the fingertips but also the whole-finger links should be utilized. Sensing of joint torque is necessary for the robot hand to work correctly, and many sensors for measuring joint torque have been proposed. In this paper, a novel torque sensor that can measure strain of the elastic body is proposed for a robot hand. The torque sensor system requires the miniaturization of both the sensor and its amplifier circuit and can be built into the mechanism of the robot hand. The system has a built-in amplifier circuit on the torque sensor frame. We perform experiments designed to show the sensor system's linearity, hysteresis, and frequency response. The motor can be controlled using a feedback signal of the torque sensor.
The Bacillus subtilis iron-sparing response is mediated by a Fur-regulated small RNA and three small, basic proteins

Regulation of bacterial iron homeostasis is often controlled by the iron-sensing ferric uptake repressor (Fur). The Bacillus subtilis Fur protein acts as an iron-dependent repressor for siderophore biosynthesis and iron transport proteins. Here, we demonstrate that Fur also coordinates an iron-sparing response that acts to repress the expression of iron-rich proteins when iron is limiting. When Fur is inactive, numerous iron-containing proteins are down-regulated, including succinate dehydrogenase, aconitase, cytochromes, and biosynthetic enzymes for heme, cysteine, and branched chain amino acids. As a result, a fur mutant grows slowly in a variety of nutrient conditions. Depending on the growth medium, rapid growth can be restored by mutations in one or more of the molecular effectors of the iron-sparing response. These effectors include the products of three Fur-regulated operons that encode a small RNA (FsrA) and three small, basic proteins (FbpA, FbpB, and FbpC). Extensive complementarity between FsrA and the leader region of the succinate dehydrogenase operon is consistent with an RNA-mediated translational repression mechanism for this target. Thus, iron deprivation in B. subtilis activates pathways to remodel the proteome to preserve iron for the most critical cellular functions.
Attitude strength : antecedents and consequences

Contents: P.E. Converse, Foreword. Preface. J.A. Krosnick, R.E. Petty, Attitude Strength: An Overview. R.P. Abelson, Attitude Extremity. C.M. Judd, M. Brauer, Repetition and Evaluative Extremity. A. Tesser, L. Martin, M. Mendolia, The Impact of Thought on Attitude Extremity and Attitude-Behavior Consistency. R.E. Petty, C.P. Haugtvedt, S.M. Smith, Elaboration as a Determinant of Attitude Strength: Creating Attitudes That Are Persistent, Resistant, and Predictive of Behavior. W.D. Crano, Attitude Strength and Vested Interest. D.S. Boninger, J.A. Krosnick, M.K. Berent, L.R. Fabrigar, The Causes and Consequences of Attitude Importance. C.J. Thomsen, E. Borgida, H. Lavine, The Causes and Consequences of Personal Involvement. S.R. Gross, R. Holtz, N. Miller, Attitude Certainty. R.H. Fazio, Attitudes as Object-Evaluation Associations: Determinants, Consequences, and Correlates of Attitude Accessibility. W. Wood, N. Rhodes, M. Biek, Working Knowledge and Attitude Strength: An Information-Processing Analysis. A.R. Davidson, From Attitudes to Actions to Attitude Change: The Effects of Amount and Accuracy of Information. J. Jaccard, C. Radecki, T. Wilson, P. Dittus, Methods for Identifying Consequential Beliefs: Implications for Understanding Attitude Strength. M.M. Thompson, M.P. Zanna, D.W. Griffin, Let's Not Be S. Chaiken, E.M. Pomerantz, R. Giner-Sorolla, Structural Consistency and Attitude Strength. A.H. Eagly, S. Chaiken, Attitude Strength, Attitude Structure, and Resistance to Change. M.W. Erber, S.D. Hodges, T.D. Wilson, Attitude Strength, Attitude Stability, and the Effects of Analyzing Reasons. D.T. Wegener, J. Downing, J.A. Krosnick, R.E. Petty, Measures and Manipulations of Strength-Related Properties of Attitudes: Current Practice and Future Directions.
Bioresorbable everolimus-eluting vascular scaffold in patients with ST-segment elevation myocardial infarction: Optical coherence tomography evaluation and clinical outcomes.

BACKGROUND Bioresorbable vascular scaffold (BVS) implantation is a new, promising treatment method of coronary artery disease. Preliminary data in patients with stable angina are encouraging. However, the utility of BVS was not sufficiently evaluated in the setting of acute thrombotic lesions. The aim of this study was an optical coherence tomography (OCT) assessment of acute procedural result of the everolimus-eluting BVS implantation in patients with ST segment elevation myocardial infarction (STEMI) and evaluation of mid-term clinical outcomes. METHODS OCT examination was conducted in 23 STEMI patients who underwent primary angioplasty with BVS implantation. Off-line qualitative and quantitative coronary angiography and OCT analyses were performed by an independent core laboratory. RESULTS Successful procedural and clinical results were achieved in 95.7% of patients, and device success was observed in all patients. In OCT evaluation, most of the struts (95.4 ± 7.96%) were well apposed, 4.6 ± 5.71% were classified as malapposed. The final minimum lumen diameter was 2.6 ± 0.35 mm, minimum scaffold area was 6.9 ± 1.54 mm² and final residual stenosis was 8.8 ± 24.37%. Edge dissections were found in 3 (7.7%) lesions. Median follow-up period was 229 (interquartile range 199-248) days. One myocardial infarction, due to sub-acute stent thrombosis, occurred in a patient who discontinued pharmacotherapy. CONCLUSIONS The study shows that everolimus-eluting BVS implantation in STEMI is safe and feasible. The OCT evaluation confirmed excellent acute performance with appropriate scaffold expansion and low rate of malapposition.
Correlates of physical beauty in men and women

Front-view drawings of male and female figures were rated for attractiveness by partici-pants of both sexes. Participant sex did not affect the physique parameters judged relatively attractive. For female stimuli, attractiveness correlated negatively with waist width and hip width, and directly with figure slenderness. For male stimuli, attractive-ness correlated positively with shoulder width and upper body taper.
The Role of ICT Actors and Networks in Development: The Case Study of a Wireless Project in Nepal

The role of ICT actors in the formation and extension of ICT4D projects is important. The actors through their extended network and aligned interest can enhance the effectiveness of the project which in turn enables socioeconomic development opportunities. However, few studies have been conducted to understand the role of these central players. The objective of this paper, therefore, is to address this knowledge gap by conducting a qualitative case study in the Myagdi district in the mountain region of Nepal. In this study we explored the Nepal Wireless Networking Project (NWNP) and examined how an activist started it from one mountain village and gradually extended across more than 150 villages. The formation and extension of information and communication technology for development (ICT4D) projects goes through different phases of identification of relevant ICT actors, roles, negotiations, and their interest alignment. To understand the various phases, we employed Actor‐Network Theory (ANT) and explored how a social activist, in the midst of challenges, initiates the wireless project to facilitate educational and healthcare services to the mountain regions. In continuum, the study found how the activist identified relevant actors and enrolled them to form a network of aligned interest. The study also identified several challenges such as high illiteracy rate, over dependency on focal actor, and poor physical infrastructure that may impede the network building process. Furthermore, we identify some implications for research and practice based on insights from the case study.
Variable Effects of Physical Training of Heart Rate Variability, Heart Rate Recovery, and Heart Rate Turbulence in Chronic Heart Failure

Background: Heart rate variability (HRV), heart rate turbulence (HRT), and heart rate recovery (HRR), indices that reflect autonomic nervous system (ANS) activity, are outcome predictors in patients with chronic heart failure (CHF). It is not clear, however, whether they reflect the same components of ANS activity. No study has examined the effects of physical training (PT) training on HRV, HRT, and HRR in CHF.
Spontaneous resolution of macular edema after silicone oil removal.

AIM To investigate the macular changes in eyes filled with silicone oil (SO) and course of these changes after SO removal. METHODS A retrospective optical coherence tomography scan review was conducted for twenty-four patients who underwent uncomplicated pars plana vitrectomy with SO tamponade for complex retinal detachments were detected with optical coherence tomography before, and one week, one month and three months after SO removal. RESULTS Mean duration of SO tamponade was 3.6±1.0mo (range: 3-7mo). Cystoid macular edema (CME) was detected in 3 eyes before SO removal. Submacular fluid was represented in 1 eye before silicone SO removal. Resolution of CME and submacular fluid was achieved 1mo after SO removal in all eyes. Mean best corrected visual acuity (BCVA) was 1.15±0.65 (range, hand movement to 0.2) before SO removal in the eyes without macular changes. After SO removal, the mean BCVA values at 1wk and 1 and 3mo, and 0.82±0.23, 0.76±0.21, and 0.70±0.19, all of which were significantly better than baseline (P=0.030, 0.017, 0.006 respectively). In the eyes with macular CME and subretinal fluid the mean BCVA was significantly improved at 3mo after SO removal compared with baseline (P=0.037). CONCLUSION Decreased visual acuity in eyes filled with SO could be caused by macular complications due to SO. CME and subretinal fluid may resolve without any additional macular surgery after SO removal.
Sleep Phenotyping in a Mouse Model of Extreme Trait Anxiety

Background There is accumulating evidence that anxiety impairs sleep. However, due to high sleep variability in anxiety disorders, it has been difficult to state particular changes in sleep parameters caused by anxiety. Sleep profiling in an animal model with extremely high vs. low levels of trait anxiety might serve to further define sleep patterns associated with this psychopathology. Methodology/Principal Findings Sleep-wake behavior in mouse lines with high (HAB), low (LAB) and normal (NAB) anxiety-related behaviors was monitored for 24 h during baseline and recovery after 6 h sleep deprivation (SD). The amounts of each vigilance state, sleep architecture, and EEG spectral variations were compared between the mouse lines. In comparison to NAB mice, HAB mice slept more and exhibited consistently increased delta power during non-rapid eye movement (NREM) sleep. Their sleep patterns were characterized by heavy fragmentation, reduced maintenance of wakefulness, and frequent intrusions of rapid eye movement (REM) sleep. In contrast, LAB mice showed a robust sleep-wake rhythm with remarkably prolonged sleep latency and a long, persistent period of wakefulness. In addition, the accumulation of delta power after SD was impaired in the LAB line, as compared to HAB mice. Conclusions/Significance Sleep-wake patterns were significantly different between HAB and LAB mice, indicating that the genetic predisposition to extremes in trait anxiety leaves a biological scar on sleep quality. The enhanced sleep demand observed in HAB mice, with a strong drive toward REM sleep, may resemble a unique phenotype reflecting not only elevated anxiety but also a depression-like attribute.