Miracle-dz/UniFAR-FTUs huggingface dataset:
Design, Response Rates, and Population Characteristics of a Cross-Sectional Study in Zanzibar, Tanzania

Background Data on nutritional status and correlates of noncommunicable diseases are scarce for resource-poor settings in sub-Saharan countries. With the scope of a project, “Access to Food and Nutrition Status of the Zanzibari Population,” data for investigating public health questions were collected using proven measurement and laboratory standards. Objective The present study aims at providing a descriptive overview of recruitment approaches, standardization, quality control measures, and data collection, with special attention to the design, responses, and participant characteristics of the overall project. Methods A cross-sectional study across 80 randomly selected Shehias (wards) was conducted in 2013 in Unguja Island, Zanzibar. Examinations included all members living in 1 household, face-to-face interviews and anthropometric measurements (weight, height, mid-upper arm circumference, waist and hip circumference, and body composition) were assessed for all household members, blood pressure was taken from participants older than 2 years, and biosamples (urine and blood) from eligible household members were collected. Data collected from the core sample included sociodemographic data, nutritional status, and medical history (hypertension). Physical activity data was collected from a subsample of children between 3 and 16 years of age. Results A total of 1314 participants (mean age 23.6 ± 18.9 years, 54.54% female) completed all anthropometric measurements and were included in the analysis. Out of which, 98.40% (1293/1314) completed the household member’s questionnaire, 93.32% (1229/1314) participants older than 2 years completed blood pressure measurements, and 64.31% (845/1314) blood samples were collected from participants older than 5 years. Underweight prevalence for the total study population was 36.53% (480/1314) with the highest prevalence in children under 14 years. Overweight and obesity was highest among females with the prevalence of 7.61% (100/1314) and 6.62% (87/1314), respectively; obesity was rare among male participants. Conclusions The study provides valuable data to investigate the interplay of socioeconomic, demographic, environmental, physiological, and behavioral factors in the development of diet-related disorders in a representative sample of the Zanzibari population.
Measurement of forces and moments around the maxillary arch for treatment of a simulated lingual incisor and high canine malocclusion using straight and mushroom archwires in fixed lingual appliances

Introduction An Orthodontic SIMulator (OSIM) was used to investigate the propagation of forces and moments around a simulated archform for a gingival displaced canine and lingual displaced lateral incisor using fixed lingual orthodontic appliances. Methods In-Ovation L self-ligating lingual brackets were bonded to anatomically shaped teeth on the OSIM, and the teeth were positioned such that a G4 NiTi 0.016" large maxillary mushroom archwire could be ligated in passive position. Each trial consisted of two movements: a 3mm lingual displacement of the 1-2 lateral incisor at 0.2 mm increments, and a 1.5 mm gingival displacement of the 2-3 canine at 0.15 mm increments (n = 50). Anterior brackets were repositioned to accommodate G4 NiTi 0.016" universal straight archwires (n = 50). Tests were completed at 37°C, and force and moment data in all directions was collected for each tooth around the arch at all increments. Results In general, the straight archwire produced significantly larger forces and moments at the centre of resistance for teeth of interest than did mushroom archwires. Specifically, the straight archwire produced 2.62 N and 3.81 N more force in the direction of tooth movement on the tooth being moved for a gingival displaced canine and lingual displaced lateral incisor, respectively, as compared to mushroom archwires. Conclusions Results from this study suggest that mushroom archwires may provide better mechanics for movement of teeth in the anterior segment when using a round archwire; however, only biomechanical data was considered in this study and there are many factors that need to be considered in treatment planning.
Modeling Microalgal Biosediment Formation Based on Attenuated Total Reflection Fourier Transform Infrared (ATR FT-IR) Monitoring

With increasing amounts of anthropogenic pollutants being released into ecosystems, it becomes ever more important to understand their fate and interactions with living organisms. Microalgae play an important ecological role as they are ubiquitous in marine environments and sequester inorganic pollutants which they transform into organic biomass. Of particular interest in this study is their role as a sink for atmospheric CO2, a greenhouse gas, and nitrate, one cause of harmful algal blooms. Novel chemometric hard-modeling methodologies have been developed for interpreting phytoplankton’s chemical and physiological adaptations to changes in their growing environment. These methodologies will facilitate investigations of environmental impacts of anthropogenic pollutants on chemical and physiological properties of marine microalgae (here: Nannochloropsis oculata). It has been demonstrated that attenuated total reflection Fourier transform infrared (ATR FT-IR) spectroscopy can gain insights into both and this study only focuses on the latter. From time-series of spectra, the rate of microalgal biomass settling on top of a horizontal ATR element is derived which reflects several of phytoplankton’s physiological parameters such as growth rate, cell concentrations, cell size, and buoyancy. In order to assess environmental impacts on such parameters, microalgae cultures were grown under 25 different chemical scenarios covering 200–600 ppm atmospheric CO2 and 0.35–0.75 mM dissolved NO3−. After recording time-series of ATR FT-IR spectra, a multivariate curve resolution–alternating least squares (MCR-ALS) algorithm extracted spectroscopic and time profiles from each data set. From the time profiles, it was found that in the considered concentration ranges only NO3− has an impact on the cells’ physiological properties. In particular, the cultures’ growth rate has been influenced by the ambient chemical conditions. Thus, the presented spectroscopic + chemometric methodology enables investigating the link between chemical conditions in a marine ecosystem and their consequences for phytoplankton living in it.
Pack Cementation Coating For 304 & 316L Stainless Steel Alloys By Using Silicon Zing Process

In this study, we investigated the synthesis of pack cemented coating on two metallic materials (304 & 316L) in order to form silicon compounds on their surface at lower temperatures (800,900 &950˚C) to avoid sintering of the pack and adhesion of material to the samples surface. In our investigation silicon was used as a master alloy and alumina (Al2O3) as a filler material. Also ammonium chloride was used as an activator with different weight percentage (5,7 &10%) ,in order to increase the efficiency of the coating layer formation process. Silicon zing of two alloys which are 304 & 316L by pack cementation process according to light optical microscope examination (LOM), the coating layer formation is a temperature and activator weight percentage dependent process, which means that it is a diffusion controlled reaction. Thus the thickness of sample silicon zed with pack content 10% activator at 950˚C is higher than the sample silicon zed with pack content 7% and 5% activator and these samples have higher thickness than samples coated at 900˚C and 800˚C at same conditions. The average coating thickness obtained by silicon zing process at 4hr by using different activator weight percentage for two selective alloys are: 1- 8.520 - 129.390 am for 304 st.st alloy. 2- 75.929 - 192.592 μm for 316L st.st alloy.
Measurement Invariance and the Five-Factor Model of Personality

This study examined measurement invariance of the NEO Five-Factor Inventory (NEO-FFI), assessing the five-factor model (FFM) of personality among Euro American (N = 290) and Asian international (N = 301) students (47.8% women, Mage = 19.69 years). The full 60-item NEO-FFI data fit the expected five-factor structure for both groups using exploratory structural equation modeling, and achieved configural invariance. Only 37 items significantly loaded onto the FFM-theorized factors for both groups and demonstrated metric invariance. Threshold invariance was not supported with this reduced item set. Groups differed the most in the item–factor relationships for Extraversion and Agreeableness, as well as in response styles. Asian internationals were more likely to use midpoint responses than Euro Americans. While the FFM can characterize broad nomothetic patterns of personality traits, metric invariance with only the subset of NEO-FFI items identified limits direct group comparisons of correlation coefficients among personality domains and with other constructs, and of mean differences on personality domains.
Association of Primary Tumor Site With Mortality in Patients Receiving Bevacizumab and Cetuximab for Metastatic Colorectal Cancer

Importance Biologic therapy (BT) (eg, bevacizumab or cetuximab) is increasingly used to treat metastatic colorectal cancer (mCRC). Recent investigations have suggested that right- or left-sided primary tumor origin affects survival and response to BT. Objective To evaluate the association of tumor origin with mortality in a diverse population-based data set of patients receiving systemic chemotherapy (SC) and bevacizumab or cetuximab for mCRC. Design, Setting, and Participants This population-based nonconcurrent cohort study of statewide California Cancer Registry data included all patients aged 40 to 85 years diagnosed with mCRC and treated with SC only or SC plus bevacizumab or cetuximab from January 1, 2004, through December 31, 2014. Patients were stratified by tumor origin in the left vs right sides. Interventions Treatment with SC or SC plus bevacizumab or cetuximab. Main Outcomes and Measures Mortality hazards by tumor origin (right vs left sides) were assessed for patients receiving SC alone or SC plus bevacizumab or cetuximab. Subgroup analysis for patients with wild-type KRAS tumors was also performed. Results A total of 11 905 patients with mCRC (6713 men [56.4%] and 5192 women [43.6%]; mean [SD] age, 60.0 [10.9] years) were eligible for the study. Among these, 4632 patients received SC and BT. Compared with SC alone, SC plus bevacizumab reduced mortality among patients with right- and left-sided mCRC, whereas SC plus cetuximab reduced mortality only among patients with left-sided tumors and was associated with significantly higher mortality for right-sided tumors (hazard ratio [HR], 1.31; 95% CI, 1.14-1.51; P < .001). Among patients treated with SC plus BT, right-sided tumor origin was associated with higher mortality among patients receiving bevacizumab (HR, 1.31; 95% CI, 1.25-1.36; P < .001) and cetuximab (HR, 1.88; 95% CI, 1.68-2.12; P < .001) BT, compared with left-sided tumor origin. In patients with wild-type KRAS tumors (n = 668), cetuximab was associated with reduced mortality among only patients with left-sided mCRC compared with bevacizumab (HR, 0.75; 95% CI, 0.63-0.90; P = .002), whereas patients with right-sided mCRC had more than double the mortality compared with those with left-sided mCRC (HR, 2.44; 95% CI, 1.83-3.25, P < .001). Conclusions and Relevance Primary tumor site is associated with response to BT in mCRC. Right-sided primary tumor location is associated with higher mortality regardless of BT type. In patients with wild-type KRAS tumors, treatment with cetuximab benefited only those with left-sided mCRC and was associated with significantly poorer survival among those with right-sided mCRC. Our results underscore the importance of stratification by tumor site for current treatment guidelines and future clinical trials.
Investigating longitudinal changes in the mechanical properties of MCF-7 cells exposed to paclitaxol using particle tracking microrheology

Evidence suggests that compression and shear wave elastography are sensitive to the mechanical property changes occuring in dying cells following chemotherapy, and can hence be used to monitor cancer treatment response. A qualitative and quantitative understanding of the mechanical changes at the cellular level would allow to better infer how these changes affect macroscopic tissue mechanical properties and therefore allow the optimization of elastographic techniques (such as shear wave elastography) for the monitoring of cancer therapy. We used intracellular particle tracking microrheology (PTM) to investigate the mechanical property changes of cells exposed to paclitaxol, a mitotic inhibitor used in cancer chemotherapy. The average elastic and viscous moduli of the cytoplasm of treated MCF-7 breast cancer cells were calculated for frequency ranges between 0.2 and 100 rad s–1 (corresponding to 0.03 and 15.92 Hz, respectively). A significant increase in the complex shear modulus of the cell cytoplasm was detected at 12 h post treatment. At 24 h after drug exposure, the elastic and viscous moduli increased by a total of 191.3 Pa (>8000×) and 9 Pa (∼9×), respectively for low frequency shear modulus measurements (at 1 rad s–1). At higher frequencies (10 rad s–1), the elastic and viscous moduli increased by 188.5 Pa (∼60×) and 1.7 Pa (∼1.1×), respectively. Our work demonstrates that PTM can be used to measure changes in the mechanical properties of treated cells and that cell elasticity significantly increases by 24 h after chemotherapy exposure.
Atmospheric correction of hyperspectral images using qualitative information about registered scene

In paper a method of atmospheric correction of hyperspectral images is proposed. On the first stage, observed image is used to obtain parameters of atmospheric distortions using common radiative transfer model. In contrast to other existing approaches we use full nonlinear form of the radiative transfer model and linear spectral model, which is applied to describe undistorted hyperspectral pixels. The combination of both models allows us to evaluate parameters of atmospheric distortions using only hyperspectral image and qualitative information about the scene. The latter is a list of spectral signatories (undistorted), which can appear in different linear combinations in the registered scene. The proposed method does not require any precedential information (sets of pixels containing predefined information) or pure hyperspectral pixels. Thus, it can be applied for blind identification of the atmospheric distortion model and for further atmospheric correction. Experimental results presented in this paper demonstrate performance of the method.
Long-term flecainide therapy in type 3 long QT syndrome

Aims Type 3 long QT syndrome (LQT3) is caused by gain-of-function mutations in the cardiac sodium channel gene (SCN5A). Previous reports on the long-term use of sodium channel blockers in LQT3 are sparse. The objective of the current study was to evaluate the long-term safety and efficacy of flecainide therapy in patients with LQT3 who carry the D1790G SCN5A mutation. Methods and results The study population comprised 30 D1790G carriers who were treated with flecainide and followed for 1-215 months (mean 145 ± 54 months, median 140 months). The mean baseline (off-drug) QTc was 522 ± 45 ms, and shortened to 469 ± 36 ms with flecainide therapy, a mean decrease of 53 ms [10.1%] (P < 0.01). A QTc longer than 500 ms was evident in 53% of carriers at baseline, and only in 13% on flecainide. All carriers while being compliant with flecainide therapy had no cardiac events during an average follow up of 83 ± 73 months. Twenty carriers stopped flecainide after an average follow up of 40 ± 42 months without symptoms. Six of them (30%) had cardiac events 1-11 months after stopping flecainide. Flecainide induced the appearance of Brugada pattern in six carriers (20%, 5 males), was stopped in three and was not associated with arrhythmia. Sinus-node dysfunction was evident in six carriers (20%) and was fully corrected by flecainide in three. Conclusions These data suggest that long-term flecainide therapy is relatively safe and effective among LQT3 patients who carry the D1790G SCN5A mutation.
Role of lymphadenectomy in intermediate-risk endometrial cancer: a matched-pair study

Objective To assess the impact of lymph node dissection (LND) on morbidity, survival, and cost for intermediate-risk endometrial cancers (IREC). Methods A multicenter retrospective cohort of 720 women with IREC (endometrioid histology with myometrial invasion <50% and grade 3; or myometrial invasion ≥50% and grades 1–2; or cervical involvement and grades 1–2) was carried out. All patients underwent hysterectomy and bilateral salpingo-oophorectomy. A matched pair analysis identified 178 pairs (178 with LND and 178 without it) equal in age, body mass index, co-morbidities, American Society of Anesthesiologist score, myometrial invasion, and surgical approach. Demographic data, pathology results, perioperative morbidity, and survival were abstracted from medical records. Disease-free survival (DFS) and overall survival (OS) was analyzed using Kaplan-Meier curves and multivariate Cox regression analysis. Cost analysis was carried out between both groups. Results Both study groups were homogeneous in demographic data and pathologic results. The mean follow-up in patients free of disease was 61.7 months (range, 12.0–275.5). DFS (hazard ratio [HR]=1.34; 95% confidence interval [CI]=0.79–2.28) and OS (HR=0.72; 95% CI=0.42–1.23) were similar in both groups, independently of nodes count. In LND group, positive nodes were found in 10 cases (5.6%). Operating time and late postoperative complications were higher in LND group (p<0.05). Infection rate was significantly higher in no-LND group (p=0.035). There were no statistical differences between both groups regarding operative morbidity and hospital stay. The global cost was similar for both groups. Conclusion Systematic LND in IREC has no benefit on survival, although it does not show an increase in perioperative morbidity or global cost.
Factors Associated with Post-traumatic Stress Symptoms in Students Who Survived 20 Months after the Sewol Ferry Disaster in Korea

Background The Sewol ferry disaster caused national shock and grief in Korea. The present study examined the prevalence and associated factors of post-traumatic stress disorder (PTSD) symptoms among the surviving students 20 months after that disaster. Methods This study was conducted using a cross-sectional design and a sample of 57 students (29 boys and 28 girls) who survived the Sewol ferry disaster. Data were collected using a questionnaire, including instruments that assessed psychological status. A generalized linear model using a log link and Poisson distribution was performed to identify factors associated with PTSD symptoms. Results The results showed that 26.3% of participants were classified in the clinical group by the Child Report of Post-traumatic Symptoms score. Based on a generalized linear model, Poisson distribution, and log link analyses, PTSD symptoms were positively correlated with the number of exposed traumatic events, peers and social support, peri-traumatic dissociation and post-traumatic negative beliefs, and emotional difficulties. On the other hand, PTSD symptoms were negatively correlated with psychological well-being, family cohesion, post-traumatic social support, receiving care at a psychiatry clinic, and female gender. Conclusion This study uncovered risk and protective factors of PTSD in disaster-exposed adolescents. The implications of these findings are considered in relation to determining assessment and interventional strategies aimed at helping survivors following similar traumatic experiences.
Combined Path Following and Compliance Control for Fully Actuated Rigid Body Systems in 3-D Space

This paper presents path following control for fully actuated rigid body systems in 3-D space. Transverse feedback linearization and a parallel transport frame are used to design a path following controller that is suitable for paths that are parametrized as regular threefold continuously differentiable curves. The application of this frame enables the handling of paths with zero curvature and reduces the complexity of the control law. The path following controller is combined with a compliance control concept. The strategy is verified by a series of measurement results on a DELTA robot with linear drives.
Robust maximum likelihood estimation of sparse vector error correction model

In econometrics and finance, the vector error correction model (VECM) is an important time series model for cointegration analysis, which is used to estimate the long-run equilibrium variable relationships. The traditional analysis and estimation methodologies assume the underlying Gaussian distribution but, in practice, heavy-tailed data and outliers can lead to the inapplicability of these methods. In this paper, we propose a robust model estimation method based on the Cauchy distribution to tackle this issue. In addition, sparse cointegration relations are considered to realize feature selection and dimension reduction. An efficient algorithm based on the majorization-minimization (MM) method is applied to solve the proposed nonconvex problem. The performance of this algorithm is shown through numerical simulations.
Drosophila Cuticular Hydrocarbons Revisited: Mating Status Alters Cuticular Profiles

Most living organisms use pheromones for inter-individual communication. In Drosophila melanogaster flies, several pheromones perceived either by contact/at a short distance (cuticular hydrocarbons, CHs), or at a longer distance (cis-vaccenyl acetate, cVA), affect courtship and mating behaviours. However, it has not previously been possible to precisely identify all potential pheromonal compounds and simultaneously monitor their variation on a time scale. To overcome this limitation, we combined Solid Phase Micro-Extraction with gas-chromatography coupled with mass-spectrometry. This allowed us (i) to identify 59 cuticular compounds, including 17 new CHs; (ii) to precisely quantify the amount of each compound that could be detected by another fly, and (iii) to measure the variation of these substances as a function of aging and mating. Sex-specific variation appeared with age, while mating affected cuticular compounds in both sexes with three possible patterns: variation was (i) reciprocal in the two sexes, suggesting a passive mechanical transfer during mating, (ii) parallel in both sexes, such as for cVA which strikingly appeared during mating, or (iii) unilateral, presumably as a result of sexual interaction. We provide a complete reassessment of all Drosophila CHs and suggest that the chemical conversation between male and female flies is far more complex than is generally accepted. We conclude that focusing on individual compounds will not provide a satisfactory understanding of the evolution and function of chemical communication in Drosophila.