Miracle-dz/UniFAR-FTUs huggingface dataset:
A Phase 1b Randomized, Controlled, Double-Blinded Dosage-Escalation Trial to Evaluate the Safety, Reactogenicity and Immunogenicity of an Adenovirus Type 35 Based Circumsporozoite Malaria Vaccine in Burkinabe Healthy Adults 18 to 45 Years of Age

Background Ad35.CS. 01 is a pre-erythrocytic malaria candidate vaccine. It is a codon optimized nucleotide sequence representing the P. falciparum circumsporozoite (CS) surface antigen inserted in a replication deficient Adenovirus 35 backbone. A Phase 1a trial has been conducted in the USA in naïve adults and showed that the vaccine was safe. The aim of this study is to assess the safety and immunogenicity of ascending dosages in sub Saharan Africa. Methods A double blind, randomized, controlled, dose escalation, phase Ib trial was conducted in a rural area of Balonghin, the Saponé health district (Burkina Faso). Forty-eight healthy adults aged 18-45 years were randomized into 4 cohorts of 12 to receive three vaccine doses (day 0, 28 and 84) of 109, 1010, 5X1010, 1011 vp of Ad35.CS. 01 or normal saline by intra muscular injection. Subjects were monitored carefully during the 14 days following each vaccination for non serious adverse events. Severe and serious adverse events were collected throughout the participant study duration (12 months from the first vaccination). Humoral and cellular immune responses were measured on study days 0, 28, 56, 84, 112 and 140. Results Of the forty-eight subjects enrolled, forty-four (91.7%) received all three scheduled vaccine doses. Local reactions, all of mild severity, occurred in thirteen (27.1%) subjects. Severe (grade 3) laboratory abnormalities occurred in five (10.4%) subjects. One serious adverse event was reported and attributed to infection judged unrelated to vaccine. The vaccine induced both antibody titers and CD8 T cells producing IFNγ and TNFα with specificity to CS while eliciting modest neutralizing antibody responses against Ad35. Conclusion Study vaccine Ad35.CS. 01 at four different dose levels was well-tolerated and modestly immunogenic in this population. These results suggest that Ad35.CS. 01 should be further investigated for preliminary efficacy in human challenge models and as part of heterologous prime-boost vaccination strategies. Trial Registration ClinicalTrials.gov NCT01018459 http://clinicaltrials.gov/ct2/show/NCT01018459
Decoupling capacitor design strategy for minimizing supply noise of ultra low voltage circuits

Supply noise is a critical problem for the robust operation of integrated circuits at ultra low voltage regimes. Although decoupling capacitance is a traditional solution, the reduction of gate capacitance at subthreshold voltage can cause area overhead. In this paper, we propose a decoupling capacitor design strategy to reduce area overhead. The strategy consists of two parts: 1) enhancing gate capacitance through circuit optimizations and 2) using remote decoupling capacitors. Remote decoupling capacitors, which can be placed far from the block to compensate, can minimize the area overhead of the capacitance-enhancing optimizations. They also exploit less utilizable silicon area. The proposed strategy improves the capacitance density by 6.1× without extra process steps, compared to the conventional approach. The gained robustness may be traded off for higher energy efficiency.
An Investigation of the Effects of Music on Thematic Apperception Test (TAT) Interpretations

This study investigated the effects of musical stimuli on Thematic Apperception Test (TAT) interpretations. Sixty participants created written interpretations of 8 TAT pictures. Twenty participants listened to music rated as having a positive emotional valence in a pilot study. 20 listened to music as having a negative emotional valence in a pilot study and a further 20 participants created TAT interpretations without musical stimulation. Results highlight that the emotional valence of background musical stimuli influenced the participants' interpretations of pictorial information. Specifically, the affective direction of participants' interpretations was found to be significantly related to the type of musical stimuli. Findings are discussed with reference to music and emotions literature highlighting the multifaceted way in which music impacts aspects of daily life.
Non-Malleable Codes Against Affine Errors

Non-malleable code is a relaxed version of error-correction codes and the decoding of modified codewords results in the original message or a completely unrelated value. Thus, if an adversary corrupts a codeword then he cannot get any information from the codeword. This means that non-malleable codes are useful to provide a security guarantee in such situations that the adversary can overwrite the encoded message. In 2010, Dziembowski et al. showed a construction for non-malleable codes against the adversary who can falsify codewords bitwise independently. In this paper, we consider an extended adversarial model (affine error model) where the adversary can falsify codewords bitwise independently or replace some bit with the value obtained by applying an affine map over a limited number of bits. We prove that the non-malleable codes (for the bitwise error model) provided by Dziembowski et al. are still non-malleable against the adversary in the affine error model.
Status of Image Management Research in Public Relations: A Cross-Discipline Content Analysis of Studies Published Between 1991 and 2011

This study reviews the status of image management research published in public relations-specific journals, as well as broader management, business, strategic communication, and communication journals, to extrapolate important trends for future research and practice. A content analysis of relevant research (n = 261) was conducted based on several criteria (area focus, application group, country of study, methodology, application of theory or conceptual framework, type of focus on image, communication type and medium). Findings suggest two considerations for the strategic communication of organizational image: 1) image as outcome, and 2) image as social influence in online communication.
Modeling pinchoff and reconnection in a Hele-Shaw cell. II. Analysis and simulation in the nonlinear regime

This is the second paper in a two part series in which we analyze two diffuse interface models to study pinchoff and reconnection in binary fluid flow in a Hele-Shaw cell with arbitrary density and viscosity contrast between the components. Diffusion between the components is limited if the components are macroscopically immiscible. In one of the systems (HSCH), the binary fluid may be compressible due to diffusion. In the other system (BHSCH), a Boussinesq approximation is used and the fluid is incompressible. In this paper, we focus on buoyancy driven flow and the Rayleigh–Taylor instability. In the fully nonlinear regime before pinchoff, results from the HSCH and BHSCH models are compared to highly accurate boundary-integral simulations of the classical sharp interface system. In this case, we find that the diffuse interface models yield nearly identical results and we demonstrate convergence to the boundary-integral solutions as the interface thickness vanishes. We find that the break-up of an unstabl.
Preparation of next-generation DNA sequencing libraries from ultra-low amounts of input DNA: Application to single-molecule, real-time (SMRT) sequencing on the Pacific Biosciences RS II

We have developed and validated an amplification-free method for generating DNA sequencing libraries from very low amounts of input DNA (500 picograms – 20 nanograms) for singlemolecule sequencing on the Pacific Biosciences (PacBio) RS II sequencer. The common challenge of high input requirements for single-molecule sequencing is overcome by using a carrier DNA in conjunction with optimized sequencing preparation conditions and re-use of the MagBead-bound complex. Here we describe how this method can be used to produce sequencing yields comparable to those generated from standard input amounts, but by using 1000-fold less starting material.
Partnering With a Higher Power

Engagement in and transitions between academic institutions may be enhanced for African American urban youth if we consider the role of religiosity, spirituality, and places of worship. This article presents the manner by which African American university students, who attended public high schools, conveyed the influence of their religious and spiritual beliefs on their academic aspirations, engagement, and achievement. Further, these students described how their connections to and support from places of worship assisted them in their educational endeavors. The data from this study, in conjunction with previous research, demonstrate the importance of knowing students’ social and contextual support for academic endeavors beyond the family and school. This type of information has the potential to assist school personnel in knowing, advising, and supporting students.
Effective Conductivity of an Isotropic Heterogeneous Medium of Lognormal Conductivity Distribution

The study aims at deriving the effective conductivity Kef of a three-dimensional heterogeneous medium whose local conductivity K(x) is a stationary and isotropic random space function of lognormal distribution and finite integral scale IY. We adopt a model of spherical inclusions of different K, of lognormal pdf, that we coin as a multi-indicator structure. The inclusions are inserted at random in an unbounded matrix of conductivity K 0 within a sphere $\Omega $, of radius R 0, and they occupy a volume fraction n. Uniform flow of flux $% U_{\infty }$ prevails at infinity. The effective conductivity is defined as the equivalent one of the sphere $\Omega ,$ under the limits $n\rightarrow 1$ and $R_{0}/I_{Y}\rightarrow \infty . $ Following a qualitative argument, we derive an exact expression of Kef by computing it at the dilute limit $% n\rightarrow 0. $ It turns out that Kef is given by the well-known self-consistent or effective medium argument. The above result is validated by accurate numerical simulation.
A Historical Analysis of Evidence-Based Practice in Social Work: The Unfinished Journey toward an Empirically Grounded Profession

We provide a novel historical account of social work practice that situates the evidence-based practice (EBP) movement as an attempt to fulfill a long-standing ambition to develop a practice grounded in empirical research. Based on Thomas Kuhn’s conceptualization of scientific paradigm shifts, we argue that social work praxis has been organized by three successive practice paradigms: moral, authority, and empirical. A systematic attempt to shift from an authority-based to an empirically based paradigm began in the 1970s with the advent of the empirical clinical practice (ECP) movement. In the wake of ECP’s downfall, EBP represents a second attempt to complete the transition, but it is currently at a crossroads. Following a historical review of the evolution of practice paradigms in social work, we compare the ECP and EBP movements both to understand ECP’s demise and to propose implications for the future of EBP.
The Risk-Utility Tradeoff for Data Privacy Models

Nowadays with growth of information technologies, organizations are constantly collecting information about individuals. Public availability of these datasets can considerably benefit the society. To ensure data privacy of a released dataset, various privacy models have been introduced. While many privacy models and techniques have been proposed for data sanitization, the area of sanitized data evaluation has received less attention. This paper investigates the four most well-known data privacy models: k-anonymity, l-diversity, t-closeness, and , ϵ-differential privacy. We evaluate the data utility (usefulness of sanitized data) and the disclosure risk (re-identification risk of an individual) of the sanitized data for each model. We use a combination of several data utility and risk metrics to measure the impact of a privacy parameter (e.g., k, ϵ) on a particular privacy model. This enables us to compare the risk-utility tradeoff of semantic privacy models such as , ϵ-differential privacy to the early syntactic models such as k-anonymity on the same scale. We used the Adult dataset from the UCI machine learning repository to conduct our experiments. Experimental results show that , ϵ-differential privacy outperforms other privacy models in terms of both data utility and disclosure risk.
Tenascin-R as a Repellent Guidance Molecule for Developing Optic Axons in Zebrafish

To investigate the role of tenascin-R in nervous system development, we studied axon pathfinding in the developing optic system of zebrafish. Zebrafish tenascin-R has the same domain structure as tenascin-R in amniotes. Amino acid sequence identity with human tenascin-R is 60%. In 3-d-old larvae, tenascin-R mRNA is expressed in scattered cells throughout the periventricular cell layer of the diencephalon and tectum. Tenascin-R immunoreactivity is not detectable in the optic nerve, optic tract, or tectal optic neuropil but immediately borders the optic tract caudally. Reducing expression of tenascin-R in 3-d-old larvae in vivo by injecting morpholinos into fertilized eggs led to excessive branching of the optic tract in 86% of all injected larvae compared with 20–37% in controls. Branches were almost exclusively caudal, where tenascin-R immunoreactivity normally borders the optic tract, suggesting a role for tenascin-R in guiding optic axons in the ventral diencephalon by a contact-repellent mechanism.
Differential Regulation by Heat Stress of Novel Cytochrome P450 Genes from the Dinoflagellate Symbionts of Reef-Building Corals

ABSTRACT Exposure to heat stress has been recognized as one of the major factors leading to the breakdown of the coral-alga symbiosis and coral bleaching. Here, we describe the presence of three new cytochrome P450 (CYP) genes from the reef-building coral endosymbiont Symbiodinium (type C3) and changes in their expression during exposure to severe and moderate heat stress conditions. Sequence analysis of the CYP C-terminal region and two conserved domains, the “PERF” and “heme-binding” domains, confirmed the separate identities of the CYP genes analyzed. In order to explore the effects of different heat stress scenarios, samples of the scleractinian coral Acropora millepora were exposed to elevated temperatures incrementally over an 18-h period (rapid thermal stress) and over a 120-h period (gradual thermal stress). After 18 h of gradual heating and incubation at 26°C, the Symbiodinium CYP mRNA pool was approximately 30% larger, while a further 6°C increase to a temperature above the average sea temperature (29°C after 72 h) resulted in a 2- to 4-fold increase in CYP expression. Both rapid heat stress and gradual heat stress at 32°C resulted in 50% to 90% decreases in CYP gene transcript abundance. Consequently, the initial upregulation of expression of CYP genes at moderately elevated temperatures (26°C and 29°C) was followed by a decrease in expression under the greater thermal stress conditions at 32°C. These findings indicate that in the coral-alga symbiosis under heat stress conditions there is production of chemical stressors and/or transcriptional factors that regulate the expression of genes, such as the genes encoding cytochrome P450 monooxygenases, that are involved in the first line of an organism's chemical defense.
Physicians' transmission prevention assessment and counseling practices with their HIV positive patients.

Physicians can help prevent transmission of HIV by assessing HIV positive patients for risky sexual and needle-sharing behaviors, and by providing risk reduction counseling. From 1995 to 1997, we gathered data on the HIV transmission prevention assessment and counseling practices of 44 San Francisco Bay area physicians in face-to-face, semistructured interviews. A refined coding scheme and constant comparative analytic method were used. Although physicians varied in their responses to coded items, two styles of engagement, at the extremes, emerged from the data: "consultant" and "collaborator. " Consultants conducted transmission prevention assessment and counseling during initial visits or upon medical cues (e.g., presence of sexually transmitted diseases) and viewed themselves primarily as information sources, whereas collaborators regularly conducted transmission prevention counseling and viewed themselves as actively helping patients reduce transmission risk. Physicians who fell between the two styles generally did not conduct regular counseling themselves, but many used referrals to health educators. The findings suggest that consultant and collaborator styles may influence patients differently, and offer insight into the role that physicians can play in transmission prevention with HIV positive patients.
Progenitor Endothelial Cell Dysfunction in Heart Failure: Clinical Implication and Therapeutic Target?

Chronic heart failure (HF) is a leading clinical and public problem affected higher risk of morbidity and mortality in different population. There is emerging evidence regarding that the epigenetic regulation may have a clue in the pathogenesis of HF. Epigenetic modifications including DNA methylation, ATP-dependent chromatin remodeling, histone modifications, and microRNA-related mechanisms, may involve in the endothelium reparation and injury through mobbing and differentiation of endothelial progenitor cell (EPCs). Recent clinical studies have shown that cardiovascular risk may contribute to epigenetic regulation of structure and functionality of EPCs leading to EPCs’ dysfunction and worsening of endothelium repair. The short commentary is represented current available evidence regarding an implication of epigenetic modifications in development of EPC dysfunction and its importance for use as a target for HF treatment.
Flexible Specialization and Regional Industrial Agglomerations: The Case of the U.S. Motion Picture Industry

Abstract In the contemporary motion picture industry, production is vertically disintegrated, organized around transactions among a network of small firms. In this regard, motion picture production resembles other industries whose production organizations can be characterized as flexibly specialized. In this theoretically informed case study, we trace the transformation of the industry from vertically integrated to vertically disintegrated flexibly specialized production and elucidate how this transformation affects the spatial location of production activities and labor market dynamics.
A Proposal For Continual Learning In Robotics

One of the main goals of autonomous robotics is to have a robot learning and adapting to a dynamically changing environment over a long operating period. In this paper we present a proposal for such continual learning, by illustrating some of the key issues we think have to be addressed in order to have a robot learning in a constructive way. We describe an experiment where a mobile robot learns to follow a novel route, by bootstrapping from two innate behaviours. This experiment constitutes a first step towards continual learning.
In vivo biogenic amine efflux in medial prefiontal cortex with imipramine, fluoxetine, and fluvoxamine

In vivo brain microdialysis was used to determine the effects of the standard tricyclic antidepressant imipramine and the two selective serotonin reuptake inhibitors (SSRIs) antidepressants, fluoxetine and fluvoxamine, on extracellular levels of norepinephrine (NE), dopamine (DA), and serotonin (5‐HT) in rat medial prefrontal cortex. When given intraperitoneally (IP), imipramine increased NE in the microdialysis perfusate, and elevated DA and 5‐HT to a lesser extent. Similar dose‐dependent increases in DA and 5‐HT were detected after IP fluoxetine, although NE was less affected. In contrast, IP fluvoxamine produced no change in basal NE nor DA, although a large increase in 5‐HT occurred at an intermediate dose. When administered directly into cortex, all three antidepressants increased 5‐HT by the same amount in a dose‐dependent fashion. Intracortical imipramine and fluoxetine increased NE, and fluoxetine and fluvoxamine both increased DA, with fluoxetine doing so at a lower concentration. These data suggest that the SSRIs are not entirely selective for serotonin in vivo. © 1994 Wiley‐Liss, Inc.
The Humorous Message Taxonomy: A Framework for the Study of Humorous Ads

Abstract This article suggests a new framework for the analysis of humor's communication effects, a model that accounts for differences in humor type, message type, and humor-message interaction. Specifically, it describes three humor processes and the five humor types that result from combining them. Next, by crossing humor types and message types, it develops a taxonomy of humorous message forms. This Humorous Message Taxonomy provides a conceptual, experimental, and managerial framework for analyzing humor's communication effects. The Humorous Message Taxonomy is used to compare a sample of humorous television commercials to those message types used in prior humor appeals research. Apparently the humorous message types that have been most frequently researched differ considerably from those that are normally aired on television. The two final sections recommend a program for the study of humor effects and offer guidelines for operationalizing and manipulating humor in subsequent research.
Revitalising the waterfront: International dimensions of dockland redevelopment

Part 1 Frameworks for analysis: development dynamics at the port-city interface, Brian Hoyle socio-economic change in the maritime quarter - the demise of "sailortown", David Hilling global imperatives, local forces and waterfront redevelopment, Ray Riley and Louis Shurmer-Smith change on the waterfront - a model-based approach, Yehuda Hayuth. Part 2 Policy and practice: policy convergence on the waterfront? - a comparative assessment of North American revitalization strategies, John Tunbridge redevelopment on the North American water-frontier - the case of Toronto, Gene Desfor et al public policy and planning of the Rotterdam waterfront - a tale of two cities, David Pinder and Kenneth Rosing public policy, physical restructuring and economic change - the Swansea experience, J.Arwel Edwards urban revitalization, public policy and the redevelopment of redundant port zones - lessons from Baltimore and Manchester, Christopher M.Law market forces ascendant - dynamics of change on the Hong Kong waterfront, Roger Bristow. Part 3 Strategic planning issues: waterfront development, economic restructuring and social impact, Iain Tweedale demand-led planning, the inner-city crisis and the labour market - London Docklands evaluated, Andrew Church the need for a more critical approach to dockland renewal, Michael Clark deindustrialization and forgotten fallow - lessons from Western European oil refining, David Pinder and Sohail Husain retreat, redundancy and revitalization - forces, trends and a research agenda, David Pinder et al.
Sexual Stratification and Sex-Role Socialization

Data on sex-role values of a sample of college women are examined to ascertain the effect of family structure, social class, and religion on sex-role values, and to support a structural theory of sex-role socialization. Patterns of dominance are found to be crucial within the family, and they act as an intervening variable between mother's education and work history, on the one hand, and sex-role values of the daughters, on the other. The relative occupational and educational resources of father and mother affect their power within the family. Sex-role values also are affected by social class, which defines options available to women and influences parental dominance. Religious background exerts an independent, but unexplained, effect.