Miracle-dz/UniFAR-FTUs huggingface dataset:
Safety Improvement Approaches in Construction Industry : A Review and Future Directions

The construction industry ranks high in the rates of severe and fatal occupational injuries due to complexity and unpredictable nature of the tasks. Decades long efforts to combat occupational accidents by using various safety improvement approaches have reached a plateau. Figures published by Bureau of Labor Statistics show an improvement in the safety of the construction industry, yet a closer look reveals that it is lagging behind most other industries. In an attempt to identify the limitation of the prevailing safety approaches, this paper has reviewed the major approaches that have been implemented to improve occupational safety in construction industry. Evaluating nine major approaches in terms of techniques and effectiveness, it was found that all the approaches transfer the burden of responsibility on the contractors. While the role of contractors in ensuring the safety of workers is undeniable, researchers are of the opinion that ideal time to consider construction safety is during design phases. Considering the prolonged involvement from the phase of inception, architects and engineers can play important role in identifying and mitigating potential hazards to the construction workers. The new approach of preventing accidents and incidents through design has been recommended in this paper as the future direction of safety improvement in the construction industry.
Fast Generalized Fourier Interpolation of Nonstationary Seismic Records

We propose a fast and efficient method for the interpolation of nonstationary seismic data. The method uses the fast generalized Fourier transform FGFT to identify the space-wavenumber evolution of nonstationary spatial signals at each temporal frequency. The nonredundant nature of FGFT renders a big computational advantage to this interpolation method. A least-squares fitting scheme is used next to retrieve the optimal FGFT coefficients representative of the ideal interpolated data. For randomly sampled data on a regular grid, we seek a sparse representation of FGFT coefficients to retrieve the missing samples. A synthetic seismic data example was used to examine the performance of the method.
Orchestration by approximation: mapping stream programs onto multicore architectures

We present a novel 2-approximation algorithm for deploying stream graphs on multicore computers and a stream graph transformation that eliminates bottlenecks. The key technical insight is a data rate transfer model that enables the computation of a "closed form", i.e., the data rate transfer function of an actor depending on the arrival rate of the stream program. A combinatorial optimization problem uses the closed form to maximize the throughput of the stream program. Although the problem is inherently NP-hard, we present an efficient and effective 2-approximation algorithm that provides a lower bound on the quality of the solution. We introduce a transformation that uses the closed form to identify and eliminate bottlenecks. We show experimentally that state-of-the art integer linear programming approaches for orchestrating stream graphs are (1) intractable or at least impractical for larger stream graphs and larger number of processors and (2)our 2-approximation algorithm is highly efficient and its results are close to the optimal solution for a standard set of StreamIt benchmark programs.
Localization of emotional and volitional facial paresis

Emotional facial paresis is characterized by impaired activation of face muscles with emotion but normal voluntary activation. We report seven patients with this sign. Their lesions involved the frontal lobe white matter, the striatocapsular territory, the anterolateral thalamus and insula, the posterior thalamus and operculum, and the mesial temporal lobe and insula each in one patient, and the posterior thalamus in two patients. Volitional facial paresis affects facial movements with voluntary effort, sparing activation on emotion. We report four such patients, with lesions involving the motor cortex in one and the pyramidal tract in the cerebral hemisphere in three.
Some Observations on Mitral and Aortic Valve Disease

292 (29%) 256 (88%) 0 35 (12%) 0 1 (0.3%) 2. Mitral stenosis (MS) 189 (19%) 0 117 (62%) 40 (21%) 13 (7%) 19 (10%) 3. MS + AS 152 (15%) 0 0 120 (79%) 0 32 (21%) 4. Aortic regurgitation (AR) † 119 (12%) 107 (90%) 0 10 (8%) 0 2 (2%) 5. Mitral regurgitation (MR) 97 (10%) 0 85 (88%) 8 (8%) 1 (1%) 3 (3%) 6. MS + AR 65 (6%) 0 52 (80%) 0 0 13 (20%) 7. MR + AR 45 (4%) 0 0 39 (87%) 0 6 (13%) 8. AS + MR 23 (2%) 0 0 21 (91%) 0 2 (9%) 9. Tricuspid stenosis + MS ± AS 28 (3%) 0 0 0 4 (14%) 24 (86%) Totals 1010 (100%) ‡ 363 (36%) 254 (25%) 273 (27%) 18 (2%) 102 (10%)
Acne Vulgaris

Acne vulgaris is the most common skin condition in the United States, affecting up to 50 million people every year, particularly adolescents and younger adults. Acne vulgaris is classified as a chronic inflammatory dermatosis that includes open or closed comedones and inflammatory lesions, including papules, pustules, or nodules. Skin follicles become clogged initially with oil, dirt, or skin. Subsequently, skin-colonizing bacteria such as Propionibacterium acnes (P. acnes) can permeate inside the pore, causing infection. Appropriate therapy for acne is patientspecific and dictated by hormonal fluctuations, skin characteristics (e.g., sebum production), and disease severity. Although morbidity and mortality with acne is low, acne can cause anxiety, depression, and low self-esteem in patients, specifically teenagers. Associated costs can exceed $3 billion per year (Bhate 2013). This chapter will focus on the treatment options for all severities of acne to assist pharmacists in making safe and effective clinical decisions.
OSA severity assessment based on sleep breathing analysis using ambient microphone

In this paper, an audio-based system for severity estimation of obstructive sleep apnea (OSA) is proposed. The system estimates the apnea-hypopnea index (AHI), which is the average number of apneic events per hour of sleep. This system is based on a Gaussian mixture regression algorithm that was trained and validated on full-night audio recordings. Feature selection process using a genetic algorithm was applied to select the best features extracted from time and spectra domains. A total of 155 subjects, referred to in-laboratory polysomnography (PSG) study, were recruited. Using the PSG's AHI score as a gold-standard, the performances of the proposed system were evaluated using a Pearson correlation, AHI error, and diagnostic agreement methods. Correlation of R=0.89, AHI error of 7.35 events/hr, and diagnostic agreement of 77.3% were achieved, showing encouraging performances and a reliable non-contact alternative method for OSA severity estimation.
Visões do mundo do terapeuta e do cliente: Impactes na aliança terapêutica

Uma das questoes que permanece polemica no tocante ao contributo de diferentes variaveis de pacientes e terapeutas para a qualidade da alianca terapeutica e, consequentemente, para a eficacia da terapia, e exactamente a do valor relativo de semelhancas e diferencas entre pacientes e terapeutas. Um destes grupos de variaveis e o das de personalidade, particularmente as relativas a “visoes do mundo”. O presente estudo foi desenhado com o objectivo central de testar se as semelhancas entre “visoes espistemicas do mundo” de terapeutas e pacientes se reflectem positivamente na qualidade da alianca terapeutica. Para o efeito foram estudadas 34 diades de terapeuta/cliente. Alguns dos resultados parecem confirmas a hipotese. Apontam-se limitacoes e sugerem-se novas investigacoes. DOI: http://dx.doi. org/10.17575/rpsicol.v15i2. 501
Serum laminin and collagen IV in inflammatory bowel disease

Background/Aims: Laminin and collagen IV have been proposed as extracellular matrix serum markers. Because fibrosis is a major complication of inflammatory bowel disease, serum concentrations of laminin and collagen IV were measured in patients with ulcerative colitis (UC) and Crohn’s disease (CD) and compared with inflammatory and healthy controls. Methods: Laminin and collagen IV serum concentrations were measured in 170 patients with inflammatory bowel disease (86 UC and 84 CD), in 23 patients with other causes of intestinal inflammation, and in 80 matched healthy controls using commercially available enzyme linked immunosorbent assays. Laminin and collagen IV concentrations were correlated with disease activity, type, localisation, and treatment. Results: Mean (SD) serum laminin concentrations were 281.0 (110.1) ng/ml in patients with UC, 275.6 (106.7) ng/ml in patients with CD, 192.0 (17.8) ng/ml in healthy controls, and 198.5 (32.5) ng/ml in inflammatory controls. Mean (SD) serum collagen IV concentrations were 72.8 (22.9) ng/ml in patients with UC, 71.0 (18.2) in patients with CD, 79.8 (12.2) ng/ml in healthy controls, and 88.9 (24.6) ng/ml in inflammatory controls. There was a significant difference among the four groups (p < 0.0001) for both markers. There was a strong correlation between serum laminin, but not collagen IV, and disease activity in both diseases. No significant association was found between these markers and disease localisation or disease type. Conclusions: Serum concentrations of laminin are increased, whereas serum concentrations of collagen IV are decreased, in patients with inflammatory bowel disease. They may be useful surrogate markers for sustained inflammation and tissue remodelling.
measles epidemics Decreasing stochasticity through enhanced seasonality in

References http://rsif.royalsocietypublishing. org/content/7/46/727.full. html#ref-list-1 This article cites 61 articles, 18 of which can be accessed free Rapid response http://rsif.royalsocietypublishing. org/letters/submit/royinterface;7/46/727 Respond to this article Subject collections (498 articles) environmental science  (203 articles) biomathematics  Articles on similar topics can be found in the following collections
Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 With Susceptibility to Type 2 Diabetes in a Japanese Population

OBJECTIVE—Recently, several genes have been shown to be associated with an increased risk of type 2 diabetes by genome-wide association studies in white populations. To further investigate the involvement of these polymorphisms in conferring susceptibility to type 2 diabetes, we examined the association of 14 single nucleotide polymorphisms (SNPs) within 11 candidate loci with type 2 diabetes in a Japanese population. RESEARCH DESIGN AND METHODS—We analyzed 14 SNPs (rs4402960 in IGF2BP2, rs10811661 in CDKN2A/B, rs1111875 and rs7923837 in HHEX, rs13266634 in SLC30A8, rs1113132 and rs11037909 in EXT2, rs9939609 and rs8050136 in FTO, rs7756992 in CDKAL1, rs1801282 in PPARG Pro12Ara, rs5219 in KCNJ11 Glu23Lys, rs7480010 in LOC387761, and rs9300039 in Ch11) in 1,630 Japanese subjects with type 2 diabetes and in 1,064 control subjects by using an invader assay or a TaqMan assay. RESULTS—Among the 11 loci examined, 6 were significantly associated with type 2 diabetes in our population by a logistic regression analysis, similar to previously reported results (rs4402960, P = 0.00009; rs10811661, P = 0.0024; rs5219, P = 0.0034; rs1111875, P = 0.0064; rs13266634, P = 0.0073; rs7756992, P = 0.0363). In this population, the remaining five loci were not significantly associated with type 2 diabetes. In addition, we identified significant association of the SNPs in FTO gene with BMI in the control subjects. CONCLUSIONS—We have identified 6 of the 11 loci that were identified by genome-wide association studies in white populations, and these loci are considered strong candidates for type 2 diabetes susceptibility across different ethnicities.
FOXO3 Is a Glucocorticoid Receptor Target and Regulates LKB1 and Its Own Expression Based on Cellular AMP Levels via a Positive Autoregulatory Loop

FOXO3 is a transcription factor involved in the regulation of multiple physiological processes including cell cycle arrest, apoptosis, oxidative stress-response and energy metabolism. Although much is known about its post-translational modification, the transcriptional regulation of FOXO3, as well as the cross-talk between transcription and post-translational events, is still poorly understood. In the present study, we show that FOXO3 is an immediate early glucocorticoid receptor (GR) target, whose transcription is even further enhanced by conditions that mimic metabolic stress. Induction of FOXO3 transcription by GR-binding steroids was reversed by concomitant treatment with the GR antagonist RU-486, but further enhanced by stimuli that activate the AMP-activated protein kinase (AMPK). Analysis of genomic DNA and chromatin immunoprecipitation, as well as luciferase reporter assays, revealed two functional glucocorticoid responsive elements within the FOXO3 promoter. Furthermore, we provide functional evidence for a phosphorylation switch that explains how glucocorticoids induce transcriptional activation of the gene but subsequently inactivate the corresponding protein by site-specific phosphorylation. Only when AMPK is stimulated, pre-existing FOXO3 becomes reverted toward an active form. Energy deprived conditions thus activate FOXO3 on two different levels, namely transcriptional and post-translational. In that way, FOXO3 acts as a metabolic stress sensor that coordinates expression of LKB1, the master upstream kinase involved in metabolic sensing, depending on the energy status of the cell. Additionally, we show that FOXO3 binds and activates its own promoter via a positive autoregulatory feedback loop. In conclusion, our data explain how catabolic glucocorticoid hormones and high intracellular AMP levels cooperate in inducing FOXO3 transcription and in activating the corresponding protein.
Bioinformatics Discovery Note Structural Drift: a Possible Path to Protein Fold Change

Along with their mutating sequences, protein structures change in time. Analyzing a formate dehydrogenase domain that is evolutionarily related to ferredoxin, but simultaneously contains all the structural elements of a β-Grasp fold, we illustrate here a mechanism termed as structural drift, by which changes to a protein fold can occur. It is commonly accepted that spatial structures of proteins are more conserved than their sequences. Many evolutionarily related proteins with pronounced structural resemblance and undetectable sequence similarity are known (Andreeva et al., 2004). Often, structural features remain preserved even after sequence signal is lost to mutations, insertions and deletions. With more protein structures being solved and compared with each other, we are beginning to see many exceptions to this general rule (Andreeva et al., 2004; Grishin, 2001). Moreover we are starting to catalogue possible evolutionary scenarios that lead to significant structural changes between homologues (Grishin, 2001). Here we discuss an example of how such changes can occur. The modular and repetitive nature of protein structures has been well characterized by Thornton and colleagues as the Russian doll effect, namely when smaller substructures are contained within larger structures (Swindells et al., 1998). In proteins that display the Russian doll effect, there are multiple levels of increased structural complexity. The protein at every new level is formed by the addition of secondary structural elements to the core of the previous level (Swindells et al., 1998). However, the common minimum core (smallest doll) always remains the same by definition, and thus the fold does not change. As an alternative to this description, one can imagine an evolutionary scenario in which addition of a few elements to a protein structure may partially or completely disrupt the old core and form a distinct subdomain that includes the newly added elements along with parts of the old core, while not the entire old core like in the Russian doll effect. This newly formed subdomain may share structural similarity to other evolutionarily unrelated proteins. We call such a phenomenon structural drift. A protein experiencing structural drift can be described as a hybrid of two overlapping subdomains, which also have overlapping elements from their respective cores. The first subdomain constitutes the old protein core and can share sequence, structural and functional similarities with its homologues. The second subdomain covers several newly added elements and * To whom correspondence should be addressed. a part of the old core, and …
Detection of specific types of human papillomavirus in cervical scrapes, anal scrapes, and anogenital biopsies by DNA hybridization

Specific varieties of human papillomavirus (HPV) infecting the anogenital region were detected in clinical samples by use of a filter hybridization technique suitable for rapid screening of cervical and anal scrapes. In this way possibly benign types (HPV6 and HPV11) could be differentiated from types thought to be capable of malignant transformation (HPV16 and HPV18). Cervical or anal canal cells were applied directly to nylon filters and fixed by u.v. irradiation before hybridization with mixed viral DNA probes under both low‐ and high‐stringency conditions. In addition, probe for the human Alu‐repeated DNA sequence was used to assess the relative amount of total nucleic acids in each sample applied to the filter. HPV DNA was detected in 3 of 19 cervical scrapes from patients with no past or present history of wart virus infection or cervical dysplasia. Within a positive study group totalling 71 patients, HPV (6/11 or 16/18) was detected in cervical scrapes from 24% of 41 patients who did not have visible genital dysplasia, 30% of 27 patients with visible genital dysplasia or cervical intraepithelial neoplasia (CIN) I, and in 1 of 3 patients with past CIN IUIII. In addition, HPV6/11 or 16/18 DNA was detected in anal scrapes from 3 of 6 male patients and in 85% of genital biopsies. A notably high proportion (4/6) of vaginal condylomata were positive with both the HPV6/11 and the HPV16/18 mixed viral DNA probes. Of the biopsies prepared for histopathology and positive for HPV DNA, the HPV group‐specific antigen could be detected in only 60%.
Pain, fatigue, and school functioning in children with cerebral palsy: a path-analytic model.

OBJECTIVE This study tests a model of how pain and fatigue, independently or in combination, relate to school functioning in pediatric cerebral palsy (CP). METHODS One hundred eighty-nine parents of children with CP completed the Pediatric Quality of Life Inventory (PedsQL) 4.0 Generic Core Scales and the PedsQL 3.0 Cerebral Palsy Module. Seventy-three children with CP completed the PedsQL. Path-analytic and mediational techniques were utilized to test the a priori model. RESULTS Data from both parent proxy-report and child self-report were found to have acceptable model fit. Results supported the existence of an indirect relationship between diagnostic subtypes and school functioning that was partially mediated by both pain and fatigue. CONCLUSIONS Pain and fatigue represent potentially modifiable targets for interventions designed to improve school functioning in children with CP.
Joint Time Synchronization and Localization of an Unknown Node in Wireless Sensor Networks

Time synchronization and localization are two important issues in wireless sensor networks. Although these two problems share many aspects in common, they are traditionally treated separately. In this paper, we present a unified framework to jointly solve time synchronization and localization problems at the same time. Furthermore, since the accuracy of synchronization and localization is very sensitive to the accuracy of anchor timings and locations, the joint time synchronization and localization problem with inaccurate anchors is also considered in this paper. For the case with accurate anchors, the joint maximum likelihood estimator and a more computationally efficient least squares (LS) estimator are proposed. When the anchor timings and locations are inaccurate, a generalized total least squares (GTLS) scheme is proposed. Crame¿r-Rao lower bounds (CRLBs) and the analytical mean square error (MSE) expressions of the LS based estimators are derived for both accurate and inaccurate anchor cases. Results show that the proposed joint estimators exhibit performances close to their respective CRLBs and outperform the separate time synchronization and localization approach. Furthermore, the derived analytical MSE expressions predict the performances of the proposed joint estimators very well.
Identification and Characterization of the Host Protein DNAJC14 as a Broadly Active Flavivirus Replication Modulator

Viruses in the Flavivirus genus of the Flaviviridae family are arthropod-transmitted and contribute to staggering numbers of human infections and significant deaths annually across the globe. To identify cellular factors with antiviral activity against flaviviruses, we screened a cDNA library using an iterative approach. We identified a mammalian Hsp40 chaperone protein (DNAJC14) that when overexpressed was able to mediate protection from yellow fever virus (YFV)-induced cell death. Further studies revealed that DNAJC14 inhibits YFV at the step of viral RNA replication. Since replication of bovine viral diarrhea virus (BVDV), a member of the related Pestivirus genus, is also known to be modulated by DNAJC14, we tested the effect of this host factor on diverse Flaviviridae family members. Flaviviruses, including the pathogenic Asibi strain of YFV, Kunjin, and tick-borne Langat virus, as well as a Hepacivirus, hepatitis C virus (HCV), all were inhibited by overexpression of DNAJC14. Mutagenesis showed that both the J-domain and the C-terminal domain, which mediates self-interaction, are required for anti-YFV activity. We found that DNAJC14 does not block YFV nor HCV NS2-3 cleavage, and using non-inhibitory mutants demonstrate that DNAJC14 is recruited to YFV replication complexes. Immunofluorescence analysis demonstrated that endogenous DNAJC14 rearranges during infection and is found in replication complexes identified by dsRNA staining. Interestingly, silencing of endogenous DNAJC14 results in impaired YFV replication suggesting a requirement for DNAJC14 in YFV replication complex assembly. Finally, the antiviral activity of overexpressed DNAJC14 occurs in a time- and dose-dependent manner. DNAJC14 overexpression may disrupt the proper stoichiometry resulting in inhibition, which can be overcome upon restoration of the optimal ratios due to the accumulation of viral nonstructural proteins. Our findings, together with previously published work, suggest that the members of the Flaviviridae family have evolved in unique and important ways to interact with this host Hsp40 chaperone molecule.
Geo-Social Clustering of Places from Check-in Data

In this paper, we develop an algorithm to cluster places not only based on their locations but also their semantics. Specifically, two places are considered similar if they are spatially close and visited by people of similar communities. With the explosion in the availability of location-tracking technologies, it has become easy to track locations and movements of users through user "check-ins". These check-ins provide insights into the community structure of people visiting a place, which is leveraged and integrated into the proposed geo-social clustering framework called GeoScop. While community detection is typically done on social networks, in our problem, we lack any network data. Rather, two people belong to the same community if they visit similar geo-social clusters. We tackle this chicken-and-egg problem through an iterative procedure of expectation maximization and DBSCAN. Extensive experiments on real check-in data demonstrate that GeoScop mines semantically meaningful clusters that cannot be found by using any of the existing clustering techniques. Furthermore, GeoScop is up to 6 times more pure in social quality than the state-of-the-art technique. The executables for the tool are available at http://www.cse. iitm.ac. in/ ~simsayan/software.html.