Miracle-dz/UniFAR-FTUs huggingface dataset:
Heavy Physical Work: Cardiovascular Load in Male Construction Workers

This study aimed to elucidate cardiovascular loads (CVL) in construction workers during work and leisure by relative heart rate (RHR) over several days. Furthermore, we sought to evaluate the level of CVL in relation to individual factors, work ability, musculoskeletal pain and subjective general health. From a group of 255 construction workers responding to the baseline questionnaire, the CVL during work and leisure time was determined by recording RHR in 42 workers over 3–4 days. Almost 60% of the workday was spent below 20% RHR. The mean RHR during work for all participants was 16% RHR, with large differences between professions. On average, the 42 workers spent 14% of the workday at a RHR above 33%, and four subjects (10%) had a mean RHR above 33% during work. Eight (19%) of the participants had a mean length of their workday exceeding calculated maximal acceptable work time. Seven persons (17%) experienced on average one or more episode(s) of 5 min or more continuously above 33% RHR. The cardiovascular load at work was significantly associated with age and V˙O2max, but not with work ability, musculoskeletal pain or subjective general health.
Nonbehavioral selection for pawns, mutants of Paramecium aurelia with decreased excitability.

The reversal response in Paramecium aurelia is mediated by calcium which carries the inward current during excitation. Electrophysiological studies indicate that strontium and barium can also carry the inward current. Exposure to high concentrations of barium rapidly paralyzes and later kills wild-type paramecia. Following mutagenesis with nitrosoguanidine, seven mutants which continued to swim in the ;high-barium' solution were selected. All of the mutants show decreased reversal behavior, with phenotypes ranging from extremely non-reversing (;extreme' pawns) to nearly wild-type reversal behavior (;partial' pawns). The mutations fall into three complementation groups, identical to the pwA, pwB, and pwC genes of Kunget al. (1975). All of the pwA and pwB mutants withstand longer exposure to barium, the pwB mutants surviving longer than the pwA mutants. Among mutants of each gene, survival is correlated with loss of reversal behavior. Double mutants (A-B, A-C, B-C), identified in the exautogamous progeny of crosses between ;partial' mutants, exhibited a more extreme non-reversing phenotype than either of their single-mutant (;partial' pawn) parents. ---Inability to reverse could be expected from an alteration in the calcium-activated reversal mechanism or in excitation. A normal calcium-activated structure was demonstrated in all pawns by chlorpromazine treatment. In a separate report (Schein, Bennett and Katz 1976) the results of electrophysiological investigations directly demonstrate decreased excitability in all of the mutants, a decrease due to an altered calcium activation. The studies of the genetics, the survival in barium and the electro-physiology of the pawns demonstrate that the pwA and pwB genes have different effects on calcium activation.
Current Issues in Software Engineering for Natural Language Processing

In Natural Language Processing (NLP), research results from software engineering and software technology have often been neglected.This paper describes some factors that add complexity to the task of engineering reusable NLP systems (beyond conventional software systems). Current work in the area of design patterns and composition languages is described and claimed relevant for natural language processing. The benefits of NLP componentware and barriers to reuse are outlined, and the dichotomies "system versus experiment" and "toolkit versus framework" are discussed.It is argued that in order to live up to its name language engineering must not neglect component quality and architectural evaluation when reporting new NLP research.
Co-amoxiclav jaundice: clinical and histological features and HLA class II association

BACKGROUND AND AIMS Jaundice associated with co-amoxiclav has been increasingly recognised. We aimed to characterise its clinical and histological features and to investigate linkage with human leucocyte antigen class II haplotypes. METHODS We identified cases in the west of Scotland in the period 1991–1997 and performed polymerase chain reaction amplification and oligonucleotide probing on whole blood. RESULTS Twenty two cases were identified (10 male, mean age 59.1 years). Jaundice occurred a median of 17 days after drug commencement, with a median peak bilirubin level of 225 μmol/l (range 84–598) and median duration of jaundice 69 days (range 29–150). Two patients had primary biliary cirrhosis and two other patients had persistently abnormal liver biochemistry on follow up. One death occurred in a frail elderly woman despite resolving jaundice. The frequency of jaundice was 1 in 78 209 co-amoxiclav prescriptions. Liver biopsy, available in 12 patients, showed perivenular bilirubinostasis, accompanying reactive ceroid laden macrophages, and portal inflammation with focal injury to interlobular bile ducts. Fourteen of 20 patients had DRB1*1501 compared with 27 of 134 controls (p<2.5×10–6; odds ratio (OR) 9.25; relative risk (RR) 6.43). Of these, seven patients were homozygous for DRB1*1501(p< 10–8; OR 35.54; RR=8.68) compared with two of 134 controls. All patients with DRB1*1501 had the extended haplotype DRB1*1501-DRB5*0101-DQA1*0102-DQB1*0602. There were no clinical or histological differences between genotypes. CONCLUSIONS Co-amoxiclav associated hepatotoxicity may have a genetic basis and be delayed, severe, and prolonged, although complete recovery is usual.
Superposition of planar voronoi tessellations

We study the tessellation obtained in the intersection of two independent planar Poisson-Voronoi tessellations and derive the means of its main geometrical characteristics. We distinguish six types of cell depending on the position of nuclei of the original tessellations. The intensity and the mean area of each type of cell are computed either in closed form or via asymptotic expansions. The model can be used to represent different types of local zones of two competing telecommunication operators where the interconnection of two subscribers induces a specific cost within each type of zone
GeoTxt: a web API to leverage place references in text

Associating place name mentions in unstructured text with their actual references in geographic space is vital to enable spatial queries and analysis. In this paper, we introduce GeoTxt, a web API plus human-usable web tool designed and implemented to tackle three components of place-reference processing from text, namely: extraction, disambiguation, and geolocation of place names mentioned in unstructured text. Current GeoTxt development is focused particularly on support for processing short microblog posts.
Low-SNR, Speaker-Dependent Speech Enhancement using GMMs and MFCCs

In this paper, we propose a two-stage speech enhancement technique. In the training stage, a Gaussian Mixture Model (GMM) of the mel-frequency cepstral coefficients (MFCCs) of a user’s clean speech is computed wherein the component densities of the GMM serve to model the user’s “acoustic classes. ” In the enhancement stage, MFCCs from a noisy speech signal are computed and the underlying clean acoustic class is identified via a maximum a posteriori (MAP) decision and a novel mapping matrix. The associated GMM parameters are then used to estimate the MFCCs of the clean speech from the MFCCs of the noisy speech. Finally, the estimated MFCCs are transformed back to a time-domain waveform. Our results show that we can improve PESQ in environments as low as−10 dB SNR.
Frequency and genome load of Epstein-Barr virus in 509 breast cancers from different geographical areas

Since the few data exploring a possible association between Epstein–Barr virus (EBV) and breast cancer are conflicting, we investigated this association together with the influences of geographical areas. 509 breast cancers were sampled from areas with varying risks of nasopharynx carcinoma (NPC) such as North Africa (Algeria and Tunisia, high-risk area); southern France (Marseille, intermediate-risk area); and northern Europe (northern France, the Netherlands and Denmark; low-risk areas). Polymerase chain reaction (PCR) of a subregion of EBV BamHIC encoding the EBERs demonstrated that 31.8% of the tumours contained the viral genome. No significant differences were observed among the geographical areas. However, positive samples showed higher loads of the EBV genome in the NPC high- and intermediate-risk areas than in the low-risk areas. EBV type 1 was the dominant strain. In situ hybridization studies using a35S-labelled riboprobe for EBER1 and a laser capture microdissection, combined with quantitative PCR, showed that EBV localization was restricted to some tumour epithelial cell clusters. EBV could not be detected in the stroma. Considering the whole population covered, the presence of the EBV genome was not correlated with age, menopausal status, tumour, size, nodal status or histological grade. © 2001 Cancer Research Campaign
The effect of mood states on variety-seeking behavior: The moderating role of price promotion

In this study we aimed to explore the effect of price promotion on the relationship between mood states and variety-seeking (VS) behavior. Participants were 133 university students, who were induced to feel either a sad or happy mood to test our hypothesis. Results indicated that price promotion mitigates the effect of affective states on VS. That is, people who are sad demonstrate more VS than those who are happy in the absence of price promotion. However, people in both mood states demonstrate similar level of VS in the presence of price promotion.
Quasi-Cyclic Low-Density Parity-Check (QC-LDPC) codes for deep space and high data rate applications

In this paper we investigate and compare the performance of a selected class of Low-Density Parity-Check (LDPC) codes, i.e. Quasi-Cyclic (QC) LDPC codes, against the currently used turbo codes for deep space and high data rate applications. This is useful in future updates of the channel code option used for such applications by the Consultative Committee for Space Data Systems (CCSDS). A wide range of different code rates is examined and the obtained Bit Error Rate (BER) performance versus the Bit Energy to Noise Spectral Density ratio (Eb/N0) is reported. Both low and high code rates are being studied, and specifically the 1/2, 1/3, 1/4 and 1/5 as well as the 2/3, 3/4 and 4/5 code rates are taken under consideration. The role of the iteration rounds in the decoding procedure of LDPC codes is also examined showing that QC-LDPC codes outperform the currently used CCSDS turbo codes. Another advantage of QC-LDPC codes is their simple encoding procedure, which reduces the encoding complexity. Since deep space applications are considered, the signals are transmitted over the Additive White Gaussian Noise (AWGN) channel, with the specific block size of 7136 bits.
Effect of treatment of isolated systolic hypertension on left ventricular mass.

CONTEXT Left ventricular (LV) hypertrophy is a common problem among elderly patients with isolated systolic hypertension (ISH), but the effect of treatment of ISH on LV mass is not known. OBJECTIVE To assess the ability of antihypertensive drug treatment to reduce LV mass in ISH. DESIGN Echocardiographic Substudy of the Systolic Hypertension in the Elderly Program (SHEP). PATIENTS A total of 104 participants at the St Louis SHEP site who had interpretable baseline echocardiograms, 94 of whom had 3-year follow-up echocardiograms. INTERVENTION The SHEP participants were randomized to placebo or active treatment with chlorthalidone (12.5-25 mg/d), with atenolol (25-50 mg/d) added if necessary to maintain goal blood pressure. MAIN OUTCOME MEASURE Change in LV mass assessed by echocardiography. RESULTS Minimum follow-up was 3 years. In the active treatment group, 91% and 80% of subjects were receiving treatment with chlorthalidone alone by the end of years 1 and 3, respectively. The LV mass index was 93 g/m2 in the active treatment group and 100 g/m2 in the placebo group (P<.001). The LV mass index declined by 13% (95% confidence interval, - 3% to - 23%) in the active treatment group compared with a 6% increase (95% confidence interval, - 3% to + 16%) in the placebo group over 3 years (P=.01). CONCLUSION Treatment of ISH with a diuretic-based regimen reduces LV mass.
Understanding the neuroinflammatory response following concussion to develop treatment strategies

Mild traumatic brain injuries (mTBI) have been associated with long-term cognitive deficits relating to trauma-induced neurodegeneration. These long-term deficits include impaired memory and attention, changes in executive function, emotional instability, and sensorimotor deficits. Furthermore, individuals with concussions show a high co-morbidity with a host of psychiatric illnesses (e.g., depression, anxiety, addiction) and dementia. The neurological damage seen in mTBI patients is the result of the impact forces and mechanical injury, followed by a delayed neuroimmune response that can last hours, days, and even months after the injury. As part of the neuroimmune response, a cascade of pro- and anti-inflammatory cytokines are released and can be detected at the site of injury as well as subcortical, and often contralateral, regions. It has been suggested that the delayed neuroinflammatory response to concussions is more damaging then the initial impact itself. However, evidence exists for favorable consequences of cytokine production following traumatic brain injuries as well. In some cases, treatments that reduce the inflammatory response will also hinder the brain's intrinsic repair mechanisms. At present, there is no evidence-based pharmacological treatment for concussions in humans. The ability to treat concussions with drug therapy requires an in-depth understanding of the pathophysiological and neuroinflammatory changes that accompany concussive injuries. The use of neurotrophic factors [e.g., nerve growth factor (NGF)] and anti-inflammatory agents as an adjunct for the management of post-concussion symptomology will be explored in this review.
Exploiting visual constraints in the synthesis of uncertainty-tolerant motion plans. II. The nondirectional backprojection

For Pt.I see ibid., p.305-10, (1993). It is shown how the introduction of visual constraints into the backprojection formalism affects the computation and structure of the nondirectional backprojection. Specifically, by examining the behavior of the visual constraints as a function of the direction of the commanded velocity, it is possible to determine the new criteria for critical velocity orientations (i.e., velocity orientations at which the topology of the directional backprojection, including visual constraint rays, might change). <<ETX>>
A novel “green” fully-integrated ultrasensitive RFID-enabled gas sensor utilizing inkjet-printed antennas and carbon nanotubes

In this paper, the integration of a flexible RFID tag with an inkjet-printed Single Walled Carbon Nanotube (SWCNT) film in a chipless sensor node for toxic gas detection was introduced for the first time. The whole module is realized on a “green” low-cost paper substrate. Carbon nanotube composites change their electric properties (e.g. resistance, dielectric properties) in the presence of very small quantities of toxic gases like ammonia and nitrogen oxide. The RFID tag is designed for the 868 MHz UHF band. When NOx gas is present, the resistance of the SWCNT film will drop, resulting in the decrease of the backscattered power which will be detected by the RFID reader to realize the reliable toxic gas detection in a non-invasive way.
Interactive mesh dragging with adaptive remeshing technique

We propose a 3D mesh dragging method useful for intuitive, efficient geometric modeling of free form polygonal models. With our method, the user can drag a part of a triangular mesh and change its position and orientation. This method is based on an adaptive remeshing procedure which evaluates the deformation of faces by dragging and properly modifies them by deleting or splitting with local topological operations. Therefore the mesh is automatically adjusted for dragging, and irregularity caused by dragging onto the mesh is no longer a concern. In addition, this method is local to the dragged portion, so its computation is efficient. We describe our adaptive remeshing method and demonstrate some dragging examples.
Towards Integrated Data Center Design

Data center design is a tedious and expensive process. Recently, this process has become even more challenging as users of cloud services expect to have guaranteed levels of availability, durability and performance. A new challenge for the service providers is to find the most cost-effective data center design and configuration that will accommodate the users’ expectations, on ever-changing workloads, and constantly evolving hardware and software components. In this paper, we argue that data center design should become a systematic process. First, it should be done using an integrated approach that takes into account both the hardware and the software interdependencies, and their impact on users’ expectations. Second, it should be performed in a “wind tunnel”, which uses large-scale simulation to systematically explore the impact of a data center configuration on both the users’ and the service providers’ requirements. We believe that this is the first step towards systematic data center design – an exciting area for future research.
06 08 51 7 v 1 24 A ug 2 00 6 Suppression of star formation in early-type galaxies by feedback from supermassive black holes

Department of Physics, University of Oxford, Oxford OX1 3RH, UK Center for Space Astrophysics, Yonsei University, Seoul 120-749, Korea Laboratoire d’Astrophysique de Marseille, 13376 Marseille Cedex 12, France California Institute of Technology, MC 405-47, Pasadena, CA 91125 Laboratory for Astronomy and Solar Physics, NASA Goddard Space Flight Center, Greenbelt, MD 20771 Department of Astronomy, Columbia University, MC 5246, New York, NY 10027 Department of Physics and Astronomy, Johns Hopkins University, Baltimore, MD 21218 Observatories of the Carnegie Institution of Washington, 813 Santa Barbara St., Pasadena, CA 91101 Department of Physics and Astronomy, UCLA, Los Angeles, CA 90095-1562
High-Throughput Screening of Metal−Organic Frameworks for CO2 Capture in the Presence of Water

Competitive coadsorption of water is a major problem in the deployment of adsorption-based CO2 capture. Water molecules may compete for adsorption sites, reducing the capacity of the material, and dehumidification prior to separating CO2 from N2 increases process complexity and cost. The development of adsorbent materials that can selectively adsorb CO2 in the presence of water would be a major step forward in the deployment of CO2 capture materials in practice. In this study, large-scale computational screening was carried out to search for metal−organic frameworks (MOFs) with high selectivity toward CO2 over H2O. Calculating framework charges for thousands of MOFs is a significant challenge, so initial screening used a fast, but approximate, charge calculation method. On the basis of the initial screening, 15 MOFs were selected, and Monte Carlo simulations were carried out to compute the adsorption isotherms for these MOFs using more accurate framework charges calculated by density functional theory. A detailed investigation was performed on the effect of using different methods for calculating partial charges, and it was found that electrostatic interactions contribute the majority of the adsorption energy of H2O in the selected MOFs.
Effect of Robot Performance on Human–Robot Trust in Time-Critical Situations

Robots have the potential to save lives in high-risk situations, such as emergency evacuations. To realize this potential, we must understand how factors such as the robot's performance, the riskiness of the situation, and the evacuee's motivation influence his or her decision to follow a robot. In this paper, we developed a set of experiments that tasked individuals with navigating a virtual maze using different methods to simulate an evacuation. Participants chose whether or not to use the robot for guidance in each of two separate navigation rounds. The robot performed poorly in two of the three conditions. The participant's decision to use the robot and self-reported trust in the robot served as dependent measures. A 53% drop in self-reported trust was found when the robot performs poorly. Self-reports of trust were strongly correlated with the decision to use the robot for guidance ( $\phi ({90}) = + 0.745$). We conclude that a mistake made by a robot will cause a person to have a significantly lower level of trust in it in later interactions.
Identification of Major Outer Surface Proteins of Streptococcus agalactiae

ABSTRACT To identify the major outer surface proteins of Streptococcus agalactiae (group B streptococcus), a proteomic analysis was undertaken. An extract of the outer surface proteins was separated by two-dimensional electrophoresis. The visualized spots were identified through a combination of peptide sequencing and reverse genetic methodologies. Of the 30 major spots identified as S. agalactiae specific, 27 have been identified. Six of these proteins, previously unidentified in S. agalactiae, were sequenced and cloned. These were ornithine carbamoyltransferase, phosphoglycerate kinase, nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase, purine nucleoside phosphorylase, enolase, and glucose-6-phosphate isomerase. Using a gram-positive expression system, we have overexpressed two of these proteins in an in vitro system. These recombinant, purified proteins were used to raise antisera. The identification of these proteins as residing on the outer surface was confirmed by the ability of the antisera to react against whole, live bacteria. Further, in a neonatal-animal model system, we demonstrate that some of these sera are protective against lethal doses of bacteria. These studies demonstrate the successful application of proteomics as a technique for identifying vaccine candidates.