Miracle-dz/UniFAR-FTUs huggingface dataset:
Preexisting Cognitive Impairment Is Associated with Postoperative Cognitive Dysfunction after Hip Joint Replacement Surgery

Background:This study investigated the prevalence of cognitive impairment in elderly noncardiac surgery patients and any association between preoperative cognitive impairment and postoperative cognitive dysfunction (POCD). Additionally, the incidence of cognitive decline at 12 months after surgery was identified. Methods:Three hundred patients for hip joint replacement and 51 nonsurgical controls aged 60 yr or older were studied in a prospective observational clinical trial. All study participants and controls completed a battery of eight neuropsychological tests before surgery and at 7 days, 3 months, and 12 months afterwards. Preoperative cognitive status was assessed using preexisting cognitive impairment (PreCI) defined as a decline of at least 2 SD on two or more of seven neuropsychological tests compared to population norms. POCD and cognitive decline were assessed using the reliable change index utilizing the results of the control group. Results:PreCI was classified in 96 of 300 (32%) patients (95% CI, 23 to 43%). After surgery, 49 of 286 (17%) patients (95% CI, 13 to 22%) and 27 of 284 (10%) patients (95% CI, 6 to 13%) demonstrated POCD at 7 days and 3 months, respectively, while 7 of 271 (3%) patients (95% CI, 1 to 4%) demonstrated cognitive decline at 12 months. Patients with PreCI had a significantly increased incidence of POCD at 7 days and 3 months and cognitive decline at 12 months. Conclusions:Patients with PreCI have an increased incidence of POCD and cognitive decline. PreCI is a good predictor of subsequent POCD and cognitive decline. The incidence of cognitive decline after 12 months in this group of patients is low.
Research on Parallel Visualization in Large-Scale Scientific Computing

In order to solve the visual problems of large-scale scientific computing, the project imports the middleware for communication, and extends the classic client-server structure into client-commware-server structure. The paper proposes a visual system model for large-scale scientific computing based on client-commware-server structure, PC-cluster and large-scale display technology. The visual system model has the virtues of generality and excellently interactive capacity, and has successfully been applied to PRIS (parallel reservoir integrated simulator), a visual system of large-scale oil simulation. Applied results prove that it has a widely applicable prospective
Cysteine String Protein Limits Expression of the Large Conductance, Calcium-Activated K+ (BK) Channel

Large-conductance, calcium-activated K+ (BK) channels are widely distributed throughout the nervous system and play an essential role in regulation of action potential duration and firing frequency, along with neurotransmitter release at the presynaptic terminal. We have previously demonstrated that select mutations in cysteine string protein (CSPα), a presynaptic J-protein and co-chaperone, increase BK channel expression. This observation raised the possibility that wild-type CSPα normally functions to limit neuronal BK channel expression. Here we show by Western blot analysis of transfected neuroblastoma cells that when BK channels are present at elevated levels, CSPα acts to reduce expression. Moreover, we demonstrate that the accessory subunits, BKβ4 and BKβ1 do not alter CSPα-mediated reduction of expressed BKα subunits. Structure-function analysis reveals that the N-terminal J-domain of CSPα is critical for the observed regulation of BK channels levels. Finally, we demonstrate that CSPα limits BK current amplitude, while the loss-of-function homologue CSPαHPD-AAA increases BK current. Our observations indicate that CSPα has a role in regulating synaptic excitability and neurotransmission by limiting expression of BK channels.
Characteristics of Magnetically Coupled Resonance based Wireless Energy Transfer Proposed

This paper reviews the magnetic coupling resonance wireless energy transmission from the principle, models and theories based on the development and classification of wireless energy transmission technologies. Firstly, it introduces MIT coupled mode theory and the main circuit theory models and experiments, summarizes and illustrates the characteristics of the two theories. Secondly, it introduces the worldwide research progress in this area, including the circuit theories, three-coil energy transfer systems, multi-receptor, four-coil energy transfer systems, frequency tunable resonance body, adaptive tuning and frequency division, the loss distribution, new materials, mutual inductance coupling and frequency tracking. Finally combined with the main research content of magnetically coupled resonant wireless energy transmission, it points out the existing problems and the direction for the studies of the theory and application next step.
Image registration: a key element for information processing

In this paper we present a brief review and examples of image registration. When one wishes to fuse multiple images from disparate sources, the first step is image registration, finding the appropriate transform which maps pixels in image 1 to the corresponding pixels in image 2. Only after this step one may begin to correctly fuse and process information from both images simultaneously.
TODA: Truthful Online Double Auction for Spectrum Allocation in Wireless Networks

The spectrum usage by a secondary user often happens in a certain geographical region and in a certain time interval, and the requests often come in an online fashion. Considering the selfish behaviors of primary users and secondary users, it is imperative to design online double spectrum auction methods. The most significant challenge is how to make the online double auction economic-robust (truthful in particular). Unfortunately, existing designs either do not consider the online requests or become untruthful when applied to scenarios when both primary users and secondary users could be selfish. In this paper, we address this problem by proposing TODA, a general framework for truthful online double auction for spectrum allocation. We assume that there is a central auctioneer, and the arrivals of secondary users' requests follow Poisson distribution. Upon receiving online spectrum requests, the central auctioneer will decide immediately which secondary and primary users will win the auction, and match winning primary users and secondary users, as well as decide how much secondary users should pay and primary users should get. To preempt existing spectrum usage is not allowed. We study the case in which the conflict graph of secondary users is a complete graph, which occurs in the urban area where the distribution of the secondary users is very dense. In this case, we design strategyproof (truthful) mechanisms for both the primary users and secondary users. To the best of our knowledge, we are the first to design truthful online double auction mechanisms for spectrum allocation. Our simulation results show that the expected social efficiency ratio of our mechanism is always above 80% compared with the off-line VCG mechanism and the spectrum utilization ratio is around 70% when the system is highly loaded.
Rearrangement of the MLL Gene Confers a Poor Prognosis in Childhood Acute Lymphoblastic Leukemia , Regardless of Presenting Age

MLL gene rearrangements are associated with an extremely poor prognosis in infants with acute lymphoblastic leukemia (ALL), but little is known about their clinical significance in older children. Therefore, we studied 45 cases of childhood ALL with abnormalities of chromosome 11q23 for rearrangement of the MLL gene to determine if this feature confers a uniformly poor prognosis. MLL gene rearrangements were detected in all 18 cases with the common t(4; 11). t(9; l l ) or t(11;19) translocations, whereas only 5 of 12 patients with either unbalanced or uncommon balanced translocations demonstrated a rearrangement. Abnormalities of the MLL gene were not detected in any of the 15 cases with a deletion or inversion of the chromosome l lq23 region. The presence of an MLL rearrangement was significantly associated with age less than 1 year (P < .001), leukocyte count >50 x lo9/
The role of the sarcoplasmic reticulum in the response of ferret and rat heart muscle to acidosis.

1. The photoprotein aequorin was micro‐injected into papillary muscles from the right ventricle of ferrets and rats. Tension and aequorin light (a function of intracellular [Ca2+]) were monitored. 2. In stimulated ferret papillary muscles, increasing the [CO2] of the bicarbonate‐buffered superfusate from 5% (pH 7.35) to 20% (pH 6.8) led to a rapid decrease of developed tension, with no significant change in the size of the intracellular Ca2+ transient which accompanies contraction. There was then a small brief recovery of tension which was accompanied by a large brief increase in the size of the Ca2+ transient. Tension then declined again before recovering more slowly, with no significant change in the size of the Ca2+ transient. 3. The time course of the Ca2+ transient was prolonged on exposure to the acid solution, but shortened on continued exposure to the acid solution. Relaxation of twitch tension became faster on exposure to the acid solution, but slowed again on continued exposure to the acid solution. 4. In the presence of 10 mM‐caffeine the size of the Ca2+ transient increased during the initial decline of developed tension, the short‐lived recovery of tension was abolished, and the Ca2+ transient became smaller during the slower recovery of developed tension. 2 microM‐ryanodine had similar effects on developed tension. 5. Addition of 10 mM‐lactic acid to the superfusate produced changes similar to those described in 2 and 3 above. 6. An intracellular acidosis, produced by the addition and subsequent withdrawal of 20 mM‐NH4Cl from the superfusate also caused changes similar to those described above. In the presence of caffeine, withdrawal of NH4Cl produced changes similar to those described in 4 above. 7. In unstimulated ferret papillary muscles, increasing superfusate [CO2] produced an increase of aequorin light when the bathing [Ca2+] was increased or in the presence of ouabain (10 microM). This increase was not inhibited by verapamil (5 microM), carbonyl cyanide p‐trifluoromethoxyphenylhydrazone (1 microM) and oligomycin (2.5 microM), but was reduced by ryanodine (2 microM). 8. Rat papillary muscles showed responses which were quantitatively different from those observed in ferret papillary muscles: the initial recovery of tension developed more slowly, and sarcoplasmic reticulum (s.r.) inhibitors had a greater inhibitory effect on the recovery of tension. 9. It is concluded that the early decline of developed tension observed during acidosis is due to a decrease in Ca2+ release by the s.r. and a decrease in Ca2+ binding by the myofilaments. (ABSTRACT TRUNCATED AT 400 WORDS)
Impact of smoke-free workplace legislation on exposures and health: possibilities for prevention

The aims of this study were to review experiences with national or statewide smoke-free workplace legislation and data on the occurrence of environmental tobacco smoke (ETS) exposure at work, to present the best estimates for health effects related to workplace ETS exposure, and to calculate corresponding population attributable fractions (PAFs) for respiratory and cardiovascular diseases for 14 European countries and the USA. Systematic searches of the Medline database were carried out, with a cut-off date of November 2005. PAFs for the main outcomes were calculated from the best disease-specific effect estimates and country-specific prevalences of work ETS exposure. Significant numbers of workers are exposed to ETS at work, i.e. ∼7.5 million workers in 15 European Union countries and 24.6 million in the USA. Workplace ETS exposure is causally linked to lung cancer and coronary heart disease, and is related to an increased risk of asthma in adults and reduced birthweight in newborns. Relatively strong evidence links ETS exposure to chronic obstructive pulmonary disease and stroke. PAFs in Europe and the USA showed that, at current workplace ETS exposure prevalences, the public health impact is substantial. Experience of national and statewide smoke-free workplace legislation from different countries shows that such legislation leads to significant reductions in employees' environmental tobacco smoke exposure at work, as well as improvements in respiratory and cardiac health.
RaPare: A Generic Strategy for Cold-Start Rating Prediction Problem

In recent years, recommender system is one of indispensable components in many e-commerce websites. One of the major challenges that largely remains open is the cold-start problem, which can be viewed as a barrier that keeps the cold-start users/items away from the existing ones. In this paper, we aim to break through this barrier for cold-start users/items by the assistance of existing ones. In particular, inspired by the classic Elo Rating System, which has been widely adopted in chess tournaments, we propose a novel rating comparison strategy (RaPare ) to learn the latent profiles of cold-start users/items. The centerpiece of our RaPare is to provide a fine-grained calibration on the latent profiles of cold-start users/items by exploring the differences between cold-start and existing users/items. As a generic strategy, our proposed strategy can be instantiated into existing methods in recommender systems. To reveal the capability of RaPare strategy, we instantiate our strategy on two prevalent methods in recommender systems, i.e., the matrix factorization based and neighborhood based collaborative filtering. Experimental evaluations on five real data sets validate the superiority of our approach over the existing methods in cold-start scenario.
The prosody of focus: a case-study with cross-linguistic implications

It is well-known that focus may have a prosodic reflection in various languages, affecting prosodic phrasing, prominence and/or intonation. However, the issue whether there is any relationship among the different kinds of prosodic marking remains unclear. This paper presents a detailed examination of the prosody of focus in European Portuguese. It is shown that there are no phrasing effects of focus; by contrast, phrasal stress and tonal events play a crucial role in the expression of focus. Implications of these findings for a cross-linguistic understanding of focus prosody are explored, namely it is argued that the prosodic reflexes are not universal, or arbitrary.
Sentiment Analysis Candidates of Indonesian Presiden 2014 with Five Class Attribute

Twitter is not only used for social media to maintain friendship, but also Twitter is used to promote and campaign. Twitter usersare free to express their opinions, including opinions about candidates of Indonesian President 2014. This research accommodate the public opinions by classified it into five class attributes : very positive, positive, neutral, negative and very negative. The classification process using Naive Bayes Classifier (NBC) with data preprocessing using tokenization, cleansing and filtering. The data used in this research are in Indonesian tweets about candidates of Indonesian President 2014, with 900 tweets of dataset and distributed to five class attributes equally. As result, highest accuracy obtained when the experiment using combination of tokenization n-gram, stopword list WEKA and emoticons, which is the values consisting 71,88% accuration, 71,6% precision, 71,9% recall, 6,1% TP rate and 65% TN rate.
Diagnosis and Monitoring of Cystinosis Using Immunomagnetically Purified Granulocytes.

BACKGROUND Cystine determination is a critical biochemical test for the diagnosis and therapeutic monitoring of the lysosomal storage disease cystinosis. The classical mixed-leukocyte cystine assay requires prompt specialized recovery/isolation following blood drawing, providing cystine concentrations normalized to total protein from assorted types of white blood cells, each with varying cystine content. METHODS We present a new workflow for cystine determination using immunomagnetic granulocyte purification, and new reference ranges established from 47 patient and 27 obligate heterozygote samples assayed. Samples were collected in acid-citrate dextrose tubes and their stability was proven to allow for overnight shipping before analysis. Cystine was quantified by LC-MS/MS. RESULTS The new method was reproducible (<15% root mean square error) and specific, assaying purified granulocytes from blood samples that no longer required immediate preparation and therefore allowing for up to 30 h before processing. There was a nearly a 2-fold increase in the therapeutic target (1.9 nmol half-cystine/mg protein) range, established using distributions of patient, obligate heterozygote, and control samples. The 2.5-97.5 percentile ranges (-2 SD to +2 SD around mean) for these cohorts were 0.67-6.05 nmol/mg protein for patients, 0.33-1.35 nmol/mg protein for obligate heterozygotes, and 0.09-0.35 nmol/mg protein for controls. CONCLUSIONS The intracellular cystine determination method using immunopurified granulocytes followed by LC-MS/MS analysis improves the inherent variability of mixed leukocyte analysis and eliminates the need for immediate sample preparation following blood draw.
Topic and Stylistic Adaptation for Speech Summarisation

Contemporary approaches to automatic speech summarisation comprise several components, among them a linguistic model (LiM) component, which is unrelated to the language model used during the recognition process. This LiM component assigns a probability to word sequences from the source text according to their likelihood of appearing in the summarised text. In this paper we investigate LiM topic and stylistic adaptation using combinations of LiMs each trained on different adaptation data. Experiments are performed on 9 talks from the TED corpus of Eurospeech conference presentations, as well as 5 news stories from CNN broadcast news data, for all of which human (TRS) and speech recogniser (ASR) transcriptions along with human summaries were used. In all ASR cases, summarisation accuracy (SumACCY) of automatically generated summaries was significantly improved by automatic LiM adaptation, with relative improvements of at least 2.5% in all experiments
Aerobic expression of Vitreoscilla hemoglobin efficiently reduces overflow metabolism in Escherichia coli.

Overflow metabolism is a prevalent problem for aerobic cultivations of Escherichia coli. Although several process and molecular approaches have been applied to prevent overflow metabolism, these approaches often result in reductions in growth rate, biomass yield or accumulation of other byproducts. In this report, we present an alternative approach based on increasing the efficiency of aerobic metabolism by the expression of the Vitreoscilla stercoraria hemoglobin (VHb) to avoid overflow metabolism. VHb is expected to increase the consumption of NADH in the respiratory chain, leading to increased activity of the tricarboxylic acid (TCA) cycle. This would result in a faster consumption of acetyl Co-A and a decrease in acetate production. When this strategy was tested in E. coli strains, acetate production decreased by 50% in MG1655 and more than 90% in W3110, without affecting growth rates or biomass yields. VHb expression in mutant strains with higher TCA activity and reduced acetate formation resulted in a significant increase in growth and glucose consumption rates, whereas acetate production did not increase. The results presented here show that enhancing the efficiency of aerobic metabolism is a valuable approach to avoid overflow metabolism in E. coli and to attain high cell densities in batch mode.
Intersubjective Consensus and the Maintenance of Normative Shared Reality

Collective beliefs about the values that are widely shared among members of a group are important constituents of the normative shared reality in the group. In two studies, we examined how (a) the circulation of a narrative that resonates with intersubjectively important values and (b) communication that threatens the normative shared reality affect people's culturally motivated evaluative responses, and their implications for the maintenance of normative shared reality. Study 1 showed that an actor received the most positive evaluation when a narrative about him was widely circulated, when his behavior signaled the central value of American culture, and when he was perceived as a symbol of American culture. Study 2 showed that formulating a communicative message that denounces the normative shared reality of a culture can elicit more positive evaluation of the culture, leading to a “saying is disbelieving” effect. The results of this research extended shared reality research, and have implications for un.
Object Recognition Based on n-gram Expression of Human Actions

In this paper, we propose a novel method for recognizing objects by observing human actions based on bag-of-features. The key contribution of our method is that human actions are represented as n-grams of symbols and used to identify specific object categories. First, features of human actions taken on a object are extracted from video images and encoded to symbols. Then, n-grams are generated from the sequence of symbols and registered for corresponding object category. For recognition phase, actions taken on the object are converted into set of n-grams in the same way and compared with ones representing object categories. We performed experiments to recognize objects in an office environment and confirmed the effectiveness of our method.
A probabilistic approach to confidence estimation and evaluation

In this paper we propose a novel way of estimating confidences for words that are recognized by a speech recognition system, together with a natural methodology for evaluating the overall quality of those confidence estimates. Our approach is based on an interpretation of a confidence as the probability that the corresponding recognized word is correct, and makes use of generalized linear models as a means for combining various predictor scores so as to arrive at confidence estimates. Experimental results using these models are presented based on four different sources of speech data: switchboard, Spanish and Mandarin CallHome, and Wall Street Journal.
Involvement of spinal muscarinic and serotonergic receptors in the anti-allodynic effect of electroacupuncture in rats with oxaliplatin-induced neuropathic pain

This study was performed to investigate whether the spinal cholinergic and serotonergic analgesic systems mediate the relieving effect of electroacupuncture (EA) on oxaliplatin-induced neuropathic cold allodynia in rats. The cold allodynia induced by an oxaliplatin injection (6 mg/kg, i.p.) was evaluated by immersing the rat's tail into cold water (4℃) and measuring the withdrawal latency. EA stimulation (2 Hz, 0.3-ms pulse duration, 0.2~0.3 mA) at the acupoint ST36, GV3, or LI11 all showed a significant anti-allodynic effect, which was stronger at ST36. The analgesic effect of EA at ST36 was blocked by intraperitoneal injection of muscarinic acetylcholine receptor antagonist (atropine, 1 mg/kg), but not by nicotinic (mecamylamine, 2 mg/kg) receptor antagonist. Furthermore, intrathecal administration of M2 (methoctramine, 10 µg) and M3 (4-DAMP, 10 µg) receptor antagonist, but not M1 (pirenzepine, 10 µg) receptor antagonist, blocked the effect. Also, spinal administration of 5-HT3 (MDL-72222, 12 µg) receptor antagonist, but not 5-HT1A (NAN-190, 15 µg) or 5-HT2A (ketanserin, 30 µg) receptor antagonist, prevented the anti-allodynic effect of EA. These results suggest that EA may have a signifi cant analgesic action against oxaliplatin-induced neuropathic pain, which is mediated by spinal cholinergic (M2, M3) and serotonergic (5-HT3) receptors.