Miracle-dz/UniFAR-FTUs huggingface dataset:
Information for mental health systems: an instrument for policy-making and system service quality

Aims. Information is crucial in mental healthcare, yet it remains undervalued by stakeholders. Its absence undermines rationality in planning, makes it difficult to monitor service quality improvement, impedes accountability and human rights monitoring. For international organizations (e.g., WHO, OECD), information is indispensable for achieving better outcomes in mental health policies, services and programs. This article reviews the importance of developing system level information with reference to inputs, processes and outputs, analyzes available tools for collecting and summarizing information, highlights the various goals of information gathering, discusses implementation issues and charts the way forward. Methods. Relevant publications and research were consulted, including WHO studies that purport to promote the use of information systems to upgrade mental health care in high- and low-middle income countries. Results. Studies have shown that once information has been collected by relevant systems and analyzed through indicator schemes, it can be put to many uses. Monitoring mental health services, represents a first step in using information. In addition, studies have noted that information is a prime resource in many other areas such as evaluation of quality of care against evidence based standards of care. Services data may support health services research where it is possible to link mental health data with other health and non-health databases. Information systems are required to carefully monitor involuntary admissions, restrain and seclusion, to reduce human rights violations in care facilities. Information has been also found useful for policy makers, to monitor the implementation of policies, to evaluate their impact, to rationally allocate funding and to create new financing models. Conclusions. Despite its manifold applications, Information systems currently face many problems such as incomplete recording, poor data quality, lack of timely reporting and feedback, and limited application of information. Corrective action is needed to upgrade data collection in outpatient facilities, to improve data quality, to establish clear rules and norms, to access adequate information technology equipment and to train health care personnel in data collection. Moreover, it is necessary to shift from mere administrative data collection to analysis, dissemination and use by relevant stakeholders and to develop a “culture of information” to dismantle the culture of intuition and mere tradition. Clinical directors, mental health managers, patient and family representatives, as well as politicians should be educated to operate with information and not just intuition.
Thinning Mesh Animations

Three-dimensional animation sequences are often represented by a discrete set of compatible triangle meshes. In order to create the illusion of a smooth motion, a sequence usually consists of a large number of frames. We propose a pre-processing algorithm that considerably reduces the number of frames required to describe the whole animation. Our method is based on Batch Neural Gas [11], a new clustering and classification approach that can be used to automatically find the most relevant frames from the sequence. The meshes from the original sequence can then be expressed as linear combinations of these few key-frames with small approximation error. The key-frames can finally be compressed with any state-of-the-art compression scheme. Overall, this leads to improved compression rates as the number of key-frames is significantly smaller than the number of original frames and the storage overhead for the reconstruction weights is marginal.
Peanut allergens are rapidly transferred in human breast milk and can prevent sensitization in mice.

BACKGROUND Food allergens have been evidenced in breast milk under physiological conditions, but the kinetic and the role of this passage in food allergies are still unclear. We then aimed to analyze the passage of peanut allergens in human breast milk and their allergenicity/immunomodulatory properties. METHODS Human breast milk was collected from two non-atopic peanut-tolerant mothers before and at different time points after ingestion of 30 g of commercial roasted peanut. Ara h 6, Ara h 6 immune complexes, and the IgE binding capacity of breast milk samples were measured using specific immunoassays. Their allergenic functionality was then assessed using cell-based assay. Finally, human breast milk obtained before or after peanut ingestion was administered intragastrically to BALB/c mice at different ages, and mice were further experimentally sensitized to peanut using cholera toxin. RESULTS Ara h 6 is detected as soon as 10 min after peanut ingestion, with peak values observed within the first hour after ingestion. The transfer is long-lasting, small quantities of peanut allergens being detected over a 24-h period. IgG-Ara h 6 and IgA-Ara h 6 immune complexes are evidenced, following a different kinetic of excretion than free allergens. Peanut allergens transferred in milk are IgE reactive and can induce an allergic reaction in vitro. However, administration of human breast milk to young mice, notably before weaning, does not lead to sensitization, but instead to partial oral tolerance. CONCLUSION The low quantities of immunologically active allergens transferred through breast milk may prevent instead of priming allergic sensitization to peanut.
Identification of Unrecognized Diabetes and Pre-diabetes in a Dental Setting

Many diabetic patients remain undiagnosed, and oral findings may offer an unrealized opportunity for the identification of affected individuals unaware of their condition. We recruited 601 individuals who presented for care at a dental clinic, were ≥ 40 years old, if non-Hispanic white, and ≥ 30 years old, if Hispanic or non-white, and had never been told they have pre-diabetes or diabetes. Those with at least one self-reported diabetes risk factor (N = 535) received a periodontal examination and a point-of-care hemoglobin A1c (HbA1c) test. A fasting plasma glucose (FPG) test was used as the study outcome, signifying potential diabetes or pre-diabetes. Performance characteristics of simple models of dysglycemia (FPG ≥ 100 mg/dL) identification were evaluated and optimal cut-offs identified. A model including only two dental variables had an estimated area under the receiver operating characteristic curve (AUC) of 0.65. The addition of a point-of-care HbA1c test improved the AUC to 0.79 (p < 0.001). The presence of ≥ 26% deep pockets or ≥ 4 missing teeth correctly identified 73% of true cases; the addition of an HbA1c ≥ 5.7% increased correct identification to 92%. Analysis of our data suggests that oral healthcare professionals have the opportunity to identify unrecognized diabetes and pre-diabetes in dental patients and refer them to a physician for further evaluation and care.
Comparison of Acceptance-Based Versus Standard Behavioral Treatment for Obesity in Adults

Setting and participants. Participants were recruited from advertisements in local newspapers and radio stations and by flyers mailed to local health care providers. Eligible participants had a body mass index (BMI) of 27–40 kg/m2, were between 21 and 65 years of age, and able to participate in physical activity. Exclusion factors included medical or psychiatric conditions that could interfere with program fulfillment or pose a risk to the participant, pregnancy, recent commencement or change to the dosage of prescription medications that cause weight gain, or participation in another weight loss program.
Dissociated Time Course of Muscle Damage Recovery Between Single- and Multi-Joint Exercises in Highly Resistance-Trained Men

Abstract Soares, S, Ferreira-Junior, JB, Pereira, MC, Cleto, VA, Castanheira, RP, Cadore, EL, Brown, LE, Gentil, P, Bemben, MG, and Bottaro, M. Dissociated time course of muscle damage recovery between single- and multi-joint exercises in highly resistance-trained men. J Strength Cond Res 29(9): 2594–2599, 2015—This study compared the time course of elbow flexor muscle recovery after multi- and single-joint exercises in highly resistance-trained men. Sixteen men (24.5 ± 5.5 years) performed, in a counterbalanced order, 8 sets of 10 repetition maximum (RM) unilateral seated row exercise and 8 sets of 10RM unilateral biceps preacher curl exercise using the contralateral arm. Maximum isometric peak torque (PT) and delayed onset muscle soreness (DOMS) were recorded at baseline (pre), 10 minutes, 24, 48, 72, and 96 hours after each exercise protocol. There was a significant decrease (p ⩽ 0.05) in elbow flexor PT 10 minutes after both the multi- and single-joint exercise sessions. However, PT decrease was greater after single-joint (26.8%) when compared with multi-joint (15.1%) exercise (p ⩽ 0.05). In addition, elbow flexor PT was lower (8.4%) than baseline 24 hours after the single-joint exercise (p < 0.01), whereas PT returned to baseline 24 hours after the multi-joint exercise. Compared with baseline, DOMS increased at 24, 48, and 72 hours after single-joint exercise (p ⩽ 0.05). However, DOMS returned to baseline levels after 72 hours after multi-joint exercise. In addition, DOMS after single-joint exercise was greater (p ⩽ 0.05) than after multi-joint exercise at 24, 48, and 72 hours after exercise. Our data suggest that after a resistance training session, highly resistance-trained men experience dissimilar elbow flexor strength recovery between single-joint and multi-joint exercises. Likewise, elbow flexor DOMS is greater and takes longer to recover after single-joint exercise.
Quality of Life with Diabetes-associated Foot Complications: Comparison Between Lower-limb Amputation and Chronic Foot Ulceration

Background: Diabetic foot complications result in huge costs for both society and individual patients. Because our team performs numerous amputations each year for complicated diabetic foot ulcers, we conducted a study comparing the quality of life of diabetic amputees with a non-amputee group experiencing a diabetic foot ulcer. The aim of this study was to get better comprehension of the influence of amputation on physical and social aspects of our patients' quality of life. Materials and Methods: This study evaluated the influence of amputation for a diabetic foot ulcer on quality of life. We compared patients having experienced an amputation for a diabetic foot ulcer at least 1 year before the study, and outpatients experiencing regular visits for a current foot ulcer with no previous history of amputation. Quality of life was reported using the Medical Outcome Study Short Form 36 item health survey (MOS SF-36). Results: Most of the chronic ulcers were neuroischemic (8/9). Except for the bodily pain, which was significantly higher in the ulcer group, no difference was found between the amputee and the ulceration-group, when considering the different items of the MOS-SF 36 scales. The ulceration-group had significantly more physical limitations and pain than the toe-or-transmetatarsal-amputation-group, whereas physical limitations were identical between the transtibial-amputation-group and the ulceration-group. Median scores were quite low in both groups, reflecting strong social and psychological consequences of diabetic foot ulcers. Global prognosis was bad with 56% of the amputees having experienced another major cardiovascular event within 20 months after amputation. Conclusion: Better understanding of the consequences of diabetic foot complications is important for the general population and especially general practitioners. Psychological evaluation and support is important before and after amputation since it is a traumatic step for patients. Level of Evidence: III, Retrospective Case Control Study
Routing Protocol for Mobile Ad HOC Networks Using Mobility Prediction

Over the lasts years there has been a growing interest on mobile ad hoc networks (MANET), in this network nodes are carried by people and connected to each other by multi-hop wireless links. Since the nodes can move freely, then the nodes mobility pattern became an important characteristic of the MANET. In this work we proposed a geographical routing protocol which takes forwarding decisions based on the current node's position and the its future position. To estimate the future position of the node we used a prediction method who has been based on real trajectories data. The algorithm proposed is compared with other proposed algorithms by simulation
Sample and Fetch-Based Large Flow Detection Mechanism in Software Defined Networks

Detecting large flows in a software-defined network accurately is important for many applications. However, due to the constraints of measurement resources such as TCAMs, the existing solutions often suffer from feasibility and accuracy issues. In this letter, by combining the advantages of sampling and flow counting, we propose FlowMon, a sample and fetch-based two-stage large flow detection mechanism. FlowMon first captures the suspicious large flows through coarse-grained sampling method, and then notifies the SDN controller to determine the true large flows from these suspicious ones by installing measurement rules in the specific OpenFlow switches. To optimize the TCAM resource allocation, we also design a dynamic flow entry assignment model. Experiment results show that FlowMon can improve the large flow detection accuracy, decrease the TCAM resource consumption, and balance the measurement load among OpenFlow switches.
Combining BCR-ABL1 transcript levels at 3 and 6 months in chronic myeloid leukemia: implications for early intervention strategies.

Several groups have shown that that the BCR-ABL1 transcript level measured at 3 or 6 months after starting treatment with tyrosine kinase inhibitors strongly predicts clinical outcomes for patients with chronic myeloid leukemia. In this work, we asked whether the prognostic value of the 3-month transcript level could be improved by combining the 3- and 6-month results. We classified patients treated with imatinib and patients treated with dasatinib according to their transcript levels at 3 months and 6 months. The patients who met the 3-month landmark but failed the 6-month one had outcomes identical to those of patients who met both landmarks, whereas the patients who failed the first landmark but met the second one had prognoses similar to those who failed both landmarks. In summary, early intervention strategies can be based robustly just on the transcript level at 3 months. This trial was registered at www.clinicaltrials. gov as # NCT01460693.
Simulation Study of iSCSI-based Storage System

iSCSI is becoming an important protocol to enable remote storage access through the ubiquitous TCP/IP network. Due to the significant shift in its transport mechanism, iSCSI-based storage system may possess different performance characteristics from the traditional storage system. Simulation offers a flexible way to study the iSCSI-based storage system. In this paper, we present a simulation work of iSCSI-based storage system based on ns2. The storage system consists of an iSCSI gateway with multiple targets, a number of storage devices that are connected to the storage router through FC-AL and clients, which access the target through iSCSI protocol. We present the system model, the implementation of the components, the validation of the model and performance evaluation based on the model. Coupled with the rich TCP/IP support from ns2, the simulation components can be effortlessly used for the performance and alternatives study of iSCSI-based storage systems, applications in broad configurations.
The Epileptic Neuron Redux

Upregulation of a T-Type Ca2+ Channel Causes a Long-Lasting Modification of Neuronal Firing Mode after Status Epilepticus Su H, Sochivko D, Becker A, Chen J, Jiang Y, Yaari Y, Beck H J Neurosci 2002;22:3645–3655 A single episode of status epilepticus (SE) causes numerous structural and functional changes in the brain that can lead to the development of a chronic epileptic condition. Most studies of this plasticity have focused on changes in excitatory and inhibitory synaptic properties. However, the intrinsic firing properties that shape the output of the neuron to a given synaptic input also may be persistently affected by SE. Thus 54% of CA1 pyramidal cells, which normally fire in a regular mode, are persistently converted to a bursting mode after an episode of SE induced by the convulsant pilocarpine. In this model, intrinsic bursts evoked by threshold-straddling depolarizations, and their underlying spike after depolarizations (ADPs), were resistant to antagonists of N-, P/Q-, or L-type Ca2+ channels but were readily suppressed by low (30–100 μM) concentrations of Ni2+ known to block T- and R-type Ca2+ channels. The density of T-type Ca2+ currents, but not of other pharmacologically isolated Ca2+ current types, was upregulated in CA1 pyramidal neurons after SE. The augmented T-type currents were sensitive to Ni2+ in the same concentration range that blocked the novel intrinsic bursting in these neurons (IC50 = 27 (μM). These data suggest that SE may persistently convert regular-firing cells to intrinsic bursters by selectively increasing the density of a Ni2+-sensitive T-type Ca2+ current. This nonsynaptic plasticity considerably amplifies the output of CA1 pyramidal neurons to synaptic inputs and most probably contributes to the development and expression of an epileptic condition after SE.
Modeling and parameter retrieving in time domain spectroscopy of material and metamaterial

In this proceeding, we present a software Fit@TDS that enables to retrieve the refractive index of a sample from a timedomain spectroscopy experiment. The software include commonly used methods where the refractive index is extracted from frequency domain data. This method has limitations when the signal is too noisy or when the absorption peak saturates the absorption. Thus, the software includes as well a new method where the refractive index are directly fitted using a model (the Drude-Lorentz for example) in the time domain. This method uses an optimization algorithm that retrieves the parameters of the model corresponding to the studied material. In this proceeding, we explain the methods and test them on fictitious samples to probe the feasibility and reliability of the proposed model.
Surgery of low-grade gliomas: towards a ‘functional neurooncology’

Purpose of review For a long time, surgery of diffuse low-grade glioma was debated because of the poor knowledge of the natural history, the lack of objective evaluation of the extent of resection, a too short follow-up and the functional risk. Recently, new technical and conceptual advances in surgery have dramatically changed the management. Recent findings Despite the lack of class I evidence, there is currently growing evidence that a more extensive surgical resection of low-grade glioma is associated with a more favorable life expectancy. The use of cortical and subcortical functional mapping allows us to tailor the resection according to individual functional boundaries, thus optimizing the extent of resection while minimizing the risk of permanent deficit less than 2%. The quality of life may also be improved, thanks to seizures control and functional rehabilitation. Summary Early surgery is currently the first treatment in low-grade glioma. Re-operation can also be considered, possibly more extensive than the first one, thanks to a functional remapping and/or a tumor shrink induced by neoadjuvant treatment, especially chemotherapy. The next step is to better evaluate the quality of life and to continue to improve it in addition to the survival to evolve towards a ‘functional neurooncology’.
Connecting the dots from fatty acids to nonalcoholic steatohepatitis: Epigenetics in the spotlight

In 1964, Vincent Allfrey discovered histone acetylation and prophetically predicted its impact on gene transcription (1). It was not until 1990 that the phenotypic effects of histone deacetylase (HDAC) inhibitors were first demonstrated in cancer cells (2). Then, in late 2006, Vorinostat became the first HDAC inhibitor to be approved by the FDA for human use (cutaneous T-cell lymphoma) (3). Although most of the pre-clinical data and clinical trials to date with HDAC inhibitors are in cancer, emerging evidence suggests their potential therapeutic role in nonmalignant disease. For example, due to their effects on transcription, HDAC inhibitors were recently implicated in inflammatory conditions, such as rheumatoid arthritis (4, 5). In the field of non alcoholic steatohepatitis (NASH), however, in the 49 years since Allfrey’s observation, only nine manuscripts containing “NASH” and “histone” in their main text were published. The study by Tian et al. in this month’s edition of Hepatology is one of these 9 papers (6).
Community, family, and subjective socioeconomic status: Relative status and adolescent health.

OBJECTIVE Relative socioeconomic status (SES) may be an important social determinant of health. The current study aimed to examine how relative SES, as measured by subjective SES, income inequality, and individual SES relative to others in the community, is associated with a wide range of adolescent health outcomes, after controlling for objective family SES. METHOD Adolescents (13-16 years; N = 2,199) from the Quebec Child and Adolescent Health and Social Survey were included. Socioeconomic measures included adolescents' subjective SES; parental education and household income; community education/employment, income, and poverty rate; and community income inequality. Health outcomes included self-rated health, mental health problems, dietary and exercise health behaviors, substance-related health behaviors, reported physical health, and biomarkers of health. Best-fitting multilevel regression models (participants nested within schools) were used to test associations. RESULTS Findings indicated that lower subjective SES was associated with poorer health outcomes. After accounting for family SES, lower community education/employment had an additional negative effect on health, while lower community income had a protective effect for certain health outcomes. There was less evidence for an independent effect of income inequality. CONCLUSIONS Findings highlight the importance of measures of relative SES that span across a number of levels and contexts, and provide further understanding into the socioeconomic gradient in adolescence.
Polarized User and Topic Tracking in Twitter

Digital traces of conversations in micro-blogging platforms and OSNs provide information about user opinion with a high degree of resolution. These information sources can be exploited to understand and monitor collective behaviours. In this work, we focus on polarisation classes, i.e., those topics that require the user to side exclusively with one position. The proposed method provides an iterative classification of users and keywords: first, polarised users are identified, then polarised keywords are discovered by monitoring the activities of previously classified users. This method thus allows tracking users and topics over time. We report several experiments conducted on two Twitter datasets during political election time-frames. We measure the user classification accuracy on a golden set of users, and analyse the relevance of the extracted keywords for the ongoing political discussion.