Miracle-dz/UniFAR-FTUs huggingface dataset:
Risco e crise: pensando os pilares da urgência psiquiátrica

This article focuses on Psychiatric Urgency and its fundamental concepts, risk and crisis. In many places, the mental health network does not have enough support to attend patients during their crises, and urgency services become responsible for the task. As a result, the mental health network, which still considers Mental Health Hospitals the most important and complex source of care support, increases the flux of patients in asylums, disregarding all the principles of Psychiatric Reform. Thus, it is necessary to discuss urgency services and devise strategies able to create new contexts that emphasize not the crisis and its symptoms, but the person suffering. People in crisis normally need help, and, in some cases, that help must be immediate. It is important to deconstruct the concept of urgency in psychiatry and consider a form of care-ethics consisting of urgent care of the person in crisis
Pluripotent stem cells: A therapeutic source for age-related macular degeneration

Age-related macular degeneration (AMD) leads to progressive loss of central vision in the elderly. At a cellular level, there is aging of the retinal pigment epithelial (RPE) cells, and accumulation of lipofuscin that interferes with the proper functioning of RPE which eventually leads to apoptosis. Treatment depends on the stage of the disease. Wet AMD which has neovascularization is managed by local therapies such as laser photocoagulation and photodynamic therapy and is managed with injections of antivascular endothelial growth factor-based therapy. Unlike the wet AMD, an effective therapy does not exist for dry AMD and geographic atrophy. Cell replacement therapy has shown promise. This review discusses the opportunities in the various types of cell-based therapy, their limitations, and what is possible for India.
Characterizing Connectivity in Brain Networks Using Magnetic Resonance Imaging

The human brain is a system of neurons that provides great computational capacity via a complicated communication network. A complete description of this network, also known as the human connectome, is an active topic of research as it would provide invaluable knowledge to cognitive neuroscience. Historically, the study of brain connectivity has been marked by a dichotomy between structure and function. Recent advances in magnetic resonance imaging (MRI) provide a potential framework for bridging this divide and allowing for a more complete window onto brain connectivity. Here, a framework for examining structural connectivity and functional connectivity in a network is presented with a focus upon the study of well-known subnetworks. An examination of the thalamo-cortical system exhibits the ability to use multivariate MRI data to model a brain network and identify localized connectivity disruptions. A study of a language-based decision-making task shows how functional and structural connectivity may be used to examine the integration of multiple subnetworks and their influence upon cognitive performance. Finally, a study of lateralization in aging demonstrates that both age-related functional and structural are associated with maintaining a high level of cognitive performance. Degree Type Dissertation Degree Name Doctor of Philosophy (PhD) Graduate Group Bioengineering First Advisor James Gee
Catchment Classification and Hydrologic Similarity

Hydrology does not yet possess a generally agreed upon catchment classification system. Such a classification framework should provide a mapping of landscape form and hydro-climatic conditions on catchment function (including partition, storage, and release of water), while explicitly accounting for uncertainty and for variability at multiple temporal and spatial scales. This framework would provide an organizing principle, create a common language, guide modeling and measurement efforts, and provide constraints on predictions in ungauged basins, as well as on estimates of environmental change impacts. In this article, we (i) review existing approaches to define hydrologic similarity and to catchment classification; (ii) discuss outstanding components or characteristics that should be included in a classification scheme; and (iii) provide a basic framework for catchment classification as a starting point for further analysis. Possible metrics to describe form, hydro-climate, and function are suggested and discussed. We close the discussion with a list of requirements for the classification framework and open questions that require addressing in order to fully implement it. Open questions include: How can we best represent characteristics of form and hydro-climatic conditions? How does this representation change with spatial and temporal scale? What functions (partition, storage, and release) are relevant at what spatial and temporal scale? At what scale do internal structure and heterogeneity become important and need to be considered?
D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes

The D2 dopamine receptor (DRD2) has been one of the most extensively investigated gene in neuropsychiatric disorders. After the first association of the TaqI A DRD2 minor (A1) allele with severe alcoholism in 1990, a large number of international studies have followed. A meta‐analysis of these studies of Caucasians showed a significantly higher DRD2 A1 allelic frequency and prevalence in alcoholics when compared to controls. Variants of the DRD2 gene have also been associated with other addictive disorders including cocaine, nicotine and opioid dependence and obesity. It is hypothesized that the DRD2 is a reinforcement or reward gene. The DRD2 gene has also been implicated in schizophrenia, posttraumatic stress disorder, movement disorders and migraine. Phenotypic differences have been associated with DRD2 variants. These include reduced D2 dopamine receptor numbers and diminished glucose metabolism in brains of subjects who carry the DRD2 A1 allele. In addition, pleiotropic effects of DRD2 variants have been observed in neurophysiologic, neuropsychologic, stress response, personality and treatment outcome characteristics. The involvement of the DRD2 gene in certain neuropsychiatric disorders opens up the potential of a targeted pharmacogenomic approach to the treatment of these disorders. © 2003 Wiley‐Liss, Inc.
General practitioners' use of evidence databases

To the Editor: We know (from a range of studies in Australia and overseas) that general practitioner (GP) use of any electronically based information to support clinical decision-making is low. It is therefore not surprising that Young and Ward found a relatively low use of the Cochrane Library. I It is also important not to evaluate the efforts of groups such as the Cochrane Collaboration prematurely, or with inappropriate criteria. The Collaboration has rightly focused its initial efforts on establishing a reliable and credible resource for evidence-based healthcare, and has completed over 500 systematic reviews in a short space of time, many of which have had a significant effect on health services around the world. However, its coverage of healthcare interventions is still relatively patchy overall (and is likely to remain so for several years). For a time this will limit its potential usefulness to GPs, who require information across a broad range of healthcare topics. Furthermore, as acknowledged by Van Der Weyden,2 the issue of GP use of information is complex, and is influenced by time and financial constraints, availability of computer hardware and software, external support for information technology infrastructure, and GP attitudes. We suggest that intervention studies and programs targeting the behaviour and structural environment of GPs will be more useful than simple "uptake" questionnaires. It may also be helpful to use the knowledge of information needs generated from GP consultations as the starting point for strategies aimed at increasing the uptake of evidence-based medicine. In Australia, we are working with the Department of Social and Preventive Medicine at the University of Queensland on a pilot clinical information service for GPs. We ask a small number of GPs to send us questions that arise during their consultations. We then prepare an evidence-based answer for them which is short but structured in such a way that the source and validity of the answer can be appraised. We use a "cascade" of
Patterns of Intra- and Interhost Nonsynonymous Variation Reveal Strong Purifying Selection in Dengue Virus

ABSTRACT Considerable uncertainty surrounds the evolutionary rates of and selection pressures acting on arthropod-borne RNA viruses (arboviruses). In particular, it is unclear why arboviruses such as dengue virus show substantial genetic variation within individual humans and mosquitoes yet low long-term rates of amino acid substitution. To address this question, I compared patterns of nonsynonymous variation in populations of dengue virus sampled at different levels of evolutionary divergence. Although nonsynonymous variation was abundant in viral populations within individual humans, there was a marked reduction in the frequency of nonsynonymous mutations in interhost comparisons. Moreover, intrahost genetic variation corresponded to a random pattern of mutation, and most of the sites that exhibited nonsynonymous variation within hosts were invariant at deeper phylogenetic levels. This loss of long-term nonsynonymous variation is the signature of extensive purifying selection such that more than 90% of all nonsynonymous mutations are deleterious. Consequently, although arboviruses are able to successfully adapt to diverse cell types, they are characterized by a high rate of deleterious mutation.
Automated learning of generative models for subcellular location: Building blocks for systems biology

The goal of location proteomics is the systematic and comprehensive study of protein subcellular location. We have previously developed automated, quantitative methods to identify protein subcellular location families, but there have been no effective means of communicating their patterns to integrate them with other information for building cell models. We built generative models of subcellular location that are learned from a collection of images so that they not only represent the pattern, but also capture its variation from cell to cell. Our models contain three components: a nuclear model, a cell shape model and a protein‐containing object model. We built models for six patterns that consist primarily of discrete structures. To validate the generated images, we showed that they are recognized with reasonable accuracy by a classifier trained on real images. We also showed that the model parameters themselves can be used as features to discriminate the classes. The models allow the synthesis of images with the expectation that they are drawn from the same underlying statistical distribution as the images used to train them. They can potentially be combined for many proteins to yield a high resolution location map in support of systems biology. © 2007 International Society for Analytical Cytology
Revascularization strategies of coronary multiple vessel disease in the Drug Eluting Stent Era: one year follow-up results of the ERACI III Trial.

OBJECTIVE To compare the incidence of major adverse cardiac and cerebrovascular events (MACCE) in patients with multiple vessel coronary artery disease treated with drug eluted stents (DES), bare metal stents, percutaneous coronary interventions (PCI) or bypass surgery (CABG). METHODS In the Argentine Randomized Study Coronary Angioplasty versus Coronary Bypass Surgery in Multiple Vessel Disease (ERACI) III trial, 225 patients with multivessel disease who received DES met clinical and angiographic inclusion criteria for the ERACI II trial. This cohort (ERACI III-DES) was compared to both ERACI II treatment arms (ERACII-PCI and ERACI II-CABG). The primary end point was freedom from MACCE at one year. RESULTS Comparison of baseline demographic and angiographic data, revealed that ERACI III-DES patients were older, smoked more, had more diabetes, hyperlipidaemia, hypertension, type C lesions and received more stents. At one year freedom from MACCE was significantly greater in ERACI III-DES cohort (88%) than ERACI II CABG (80.5% p=0.038) and ERACI II PCI (78% p=0.006) patients. The ERACI III-DES cohort had similar freedom from death and acute myocardial infarction (AMI) to ERACI II PCI patients but greater than ERACI II-CABG arm. Freedom from repeat revascularization was similar between ERACI III-DES to ERACI II-CABG (95.1% p=ns) patients, but both were significantly better than those in the ERACI II-PCI arm ( 91.2% and 83%p=0.002 and 0.02 respectively). CONCLUSION Patients with multiple vessel disease treated with DES in ERACI III had better one year outcomes than those treated with PCI or CABG in ERACI II.
The Effect of Nursing Professional Pay Structures and Pay Levels on Hospitals' Heart Attack Outcomes

Abstract: The effect of nursing professionals (i.e., nurse aid/orderly, licensed practical nurse, registered nurse) pay structures and pay levels on hospitals risk-adjusted heart attack outcomes was determined. Operationalizing hospitals' heart attack outcomes as their thirty-day risk-adjusted mortality rates, a positive curvilinear relation is hypothesized between pay dispersion and hospitals' heart attack outcomes, whereas a direct relation is hypothesized between pay level and hospitals' heart attack outcomes. Pay level is also hypothesized as a moderator of the relation between pay dispersion and hospitals' heart attack outcomes. Using a sample of 138 California hospitals, support is not found for either the curvilinear relation between hospitals' nursing professionals pay dispersion and hospitals' heart attack outcomes, or the direct relation between nursing professionals' pay level and hospitals' heart attack outcomes. Support is found for the moderation hypothesis in which nursing professionals' pay level moderates the relation between hospitals' nursing professionals pay dispersion and hospitals' heart attack outcomes. Implications for practice are discussed in light of the study's results.
Exploring FSTprinciples in Community Development: The ‘Carrot on a Stick’ Early Health Intervention Programme

case study is presented to examine the durability of the five principles of feminist systems theory devised to improve community development projects and produce better outcomes for marginalised people and the environment. The development of these principles can be traced to work comparing two emancipatory epistemologies, Critical Systems Thinking and Cultural Ecofeminism (Stephens, Jacobson, King, 2009) and were then exposed to broader literature (Stephens, Jacobson, King, 2010). The principles guide social science and management research. This paper presents a case study of a community based healthy lifestyle intervention programme based in Cairns, Far North Queensland, Australia. The Carrot on a Stick programme was retrospectively analysed from the perspective of each of the five principles. The principles did not inform the original design of the programme, yet the study reveals that four of the principles are present and inform the implementation of Carrot on a Stick. The study holds implications for the design and evaluation of community intervention programmes, especially when they involve people from culturally and linguistically diverse backgrounds.
Backgate Modulation Technique for Higher Efficiency Envelope Tracking

A novel backgate modulation technique alleviating limitations associated with supply-regulated polar transmitters is proposed. The backgate of a partially depleted silicon-on-insulator metal-semiconductor field-effect transistor with a breakdown voltage of 15 V is used to modulate the gain and output power of an RF power amplifier (PA). The high-impedance backgate provides high-efficiency and wide-dynamic-range modulation of PA gain. Measured results at 1.8 GHz demonstrate 16% power-added efficiency improvement at 6-dB backed-off output power, compared with the same RF PA without backgate modulation.
Role of ROBO4 Signalling in Developmental and Pathological Angiogenesis

Transmembrane roundabout receptor family members (ROBO1–ROBO4) principally orchestrate the neuronal guidance mechanism of the nervous system. Secreted glycoprotein SLITs are the most appreciated ligands for ROBOs. Recently identified ROBO4 is the key mediator of SLIT-ROBO mediated developmental and pathological angiogenesis. Although SLIT2 has been shown to interact with ROBO4 as ligand, it remains an open question whether this protein is the physiologic partner of ROBO4. The purpose of this review is to summarise how reliable SLIT2 as ligand for ROBO4 is, if not what the other possible mechanisms demonstrated till date for ROBO4 mediated developmental and pathological angiogenesis are. We conclude that ROBO4 is expressed specially in vascular endothelial cells and maintains the vascular integrity via either SLIT2 dependent or SLIT2 independent manner. On the contrary, it promotes the pathological angiogenesis by involving different signalling arm(s)/unknown ligand(s). This review explores the interactions SLIT2/ROBO1, SLIT2/ROBO1–ROBO4, ROBO1/ROBO4, and ROBO4/UNC5B which can be promising and potential therapeutic targets for developmental angiogenesis defects and pathological angiogenesis. Finally we have reviewed the ROBO4 signalling pathways and made an effort to elaborate the insight of this signalling as therapeutic target of pathological angiogenesis.
Fuzzy Image Segmentation Using Membership Connectedness

Fuzzy connectedness and fuzzy clustering are two well-known techniques for fuzzy image segmentation. The former considers the relation of pixels in the spatial space but does not inherently utilize their feature information. On the other hand, the latter does not consider the spatial relations among pixels. In this paper, a new segmentation algorithm is proposed in which these methods are combined via a notion called membership connectedness. In this algorithm, two kinds of local spatial attractions are considered in the functional form of membership connectedness and the required seeds can be selected automatically. The performance of the proposed method is evaluated using a developed synthetic image dataset and both simulated and real brain magnetic resonance image (MRI) datasets. The evaluation demonstrates the strength of the proposed algorithm in segmentation of noisy images which plays an important role especially in medical image applications.
Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats.

Irinotecan, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11), is a potent anticancer drug that is increasingly used in chemotherapy. A frequent limiting side effect involves gastrointestinal toxicity (diarrhea), which is thought to be related to the biliary excretion of CPT-11 and its metabolites. Accordingly, the biliary excretion mechanisms for both the lactone and carboxylate forms of CPT-11 and its metabolites, SN-38 and its glucuronide (SN38-Glu), were investigated using Sprague-Dawley (SD) rats and Eisai hyperbilirubinemic rats (EHBR), with the latter being mutant rats with a genetic deficiency of the canalicular multispecific organic anion transporter. After i.v. administration of CPT-11, the biliary excretion clearance, defined as the biliary excretion rate normalized to the hepatic concentration, of both the lactone and carboxylate forms of SN38-Glu was much lower in EHBR. The biliary excretion clearance for the carboxylate form of both CPT-11 and SN-38 was also substantially smaller in EHBR and showed marked saturation with increasing dose only in SD rats. On the other hand, the biliary excretion clearance for the lactone forms of CPT-11 and SN-38 showed only a minimal difference in EHBR, compared with SD rats. These results suggest that, for the carboxylate form of CPT-11 and SN-38 and the carboxylate and lactone forms of SN38-Glu, there exists a specific transport system at the bile canalicular membrane that is deficient in EHBR. To confirm this hypothesis, the uptake of these substrates by isolated hepatic canalicular membrane vesicles (CMV) was examined. ATP-dependence was clearly observed for the uptake of these four compounds by CMV prepared from SD rats but not by CMV from EHBR. In addition, the compounds inhibited the ATP-dependent uptake of S-(2,4-dinitrophenyl) glutathione by CMV from SD rats, in a concentration-dependent manner. These results suggest that the biliary excretion of the carboxylate forms of CPT-11 and SN-38 and the carboxylate and lactone forms of SN38-Glu is mediated by the multispecific organic anion transporter, which is deficient in EHBR.
Will the Circle Be Unbroken: A History of the U.S. National Ambient Air Quality Standards

Abstract In celebration of the 100th anniversary of the Air & Waste Management Association, this review examines the history of air quality management (AQM) in the United States over the last century, with an emphasis on the ambient standards programs established by the landmark 1970 Clean Air Act (CAA) Amendments. The current CAA system is a hybrid of several distinct air pollution control philosophies, including the recursive or circular system driven by ambient standards. Although this evolving system has resulted in tremendous improvements in air quality, it has been far from perfect in terms of timeliness and effectiveness. The paper looks at several periods in the history of the U.S. program, including: (1) 1900–1970, spanning the early smoke abatement and smog control programs, the first federal involvement, and the development of a hybrid AQM approach in the 1970 CAA; (2) 1971–1976, when the first National Ambient Air Quality Standards (NAAQS) were set and implemented; (3) 1977–1993, a period of the first revisions to the standards, new CAA Amendments, delays in implementation and decision–making, and key science/policy/legislative developments that would alter both the focus and scale of air pollution programs and how they are implemented; and (4) 1993–2006, the second and third wave of NAAQS revisions and their implementation in the context of the 1990 CAA. This discussion examines where NAAQS have helped drive implementation programs and how improvements in both effects and air quality/control sciences influenced policy and legislation to enhance the effectiveness of the system over time. The review concludes with a look toward the future of AQM, emphasizing challenges and ways to meet them. The most significant of these is the need to make more efficient progress toward air quality goals, while adjusting the system to address the growing intersections between air quality management and climate change.
Superior Strength of Austenitic Steel Produced by Combined Processing, including Equal-Channel Angular Pressing and Rolling

Enhancement in the strength of austenitic steels with a small content of carbon can be achieved by a limited number of methods, among which is ultrafine-grained (UFG) structure formation. This method is especially efficient with the use of severe plastic deformation (SPD) processing, which significantly increases the contribution of grain-boundary strengthening, and also involves a combination of the other strengthening factors (work hardening, twins, etc.). In this paper, we demonstrate that the use of SPD processing combined with conventional methods of deformation treatment of metals, such as rolling, may lead to additional strengthening of UFG steel. In the presented paper we analyze the microstructure and mechanical properties of the Cr–Ni stainless austenitic steel after a combined deformation. We report on substantial increases in the strength properties of this steel, resulting from a consecutive application of SPD processing via equal-channel angular pressing and rolling at a temperature of 400 °C. This combined loading yields a strength more than 1.5 times higher than those produced by either of these two techniques used separately.