Miracle-dz/UniFAR-FTUs huggingface dataset:
Trajectory Optimization of a Pendulum-Driven Underactuated Cart

The control problem of the pendulum-driven cart has been well studied in several literatures. The challenge issue of control of such underactuated system is to control the motions of the pendulum and the cart by applying only one control torque. However, these literatures mostly focused on addressing the dynamic modeling and the tracking control design. Few papers have considered the trajectory planning of the system which is still an open issue. This paper studies the optimization for the trajectory planning of the system by considering three questions: 1) the furthest cart displacement; 2) the fastest average cart speed; 3) the most efficient power consumption. The paper systematically studies the system dynamics, the system constraints, the tracking control method, some initializations for the optimization problems, and the solutions for the three optimal questions. Extensive simulation studies are given to identify the optimum trajectories of the system.
5-hydroxytryptamine receptor (5-HT1DR) promotes colorectal cancer metastasis by regulating Axin1/β-catenin/MMP-7 signaling pathway

Overexpression of 5-hydroxytryptamine (5-HT) in human cancer contributes to tumor metastasis, but the role of 5-HT receptor family in cancer has not been thoroughly explored. Here, we report overexpression of 5-HT1D receptor (5-HT1DR) was associated with Wnt signaling pathway and advanced tumor stage. The underlying mechanism of 5-HT1DR-promoted tumor invasion was through its activation on the Axin1/β-catenin/MMP-7 pathway. In an orthotopic colorectal cancer mouse model, we demonstrated that a 5-HT1DR antagonist (GR127935) effectively inhibited tumor metastasis through targeting Axin1. Furthermore, in intestinal epithelium cells, we observed that 5-HT1DR played an important role in cell invasion via Axin1/β-catenin/MMP-7 pathway. Together, our findings reveal an essential role of the physiologic level of 5-HT1DR in pulmonary metastasis of colorectal cancer.
Prosodic cues for perceptual task-oriented Human-H

This paper addresses the question of perceptual detection and prosodic cues analysis of emotional behavior in a spontaneous speech corpus of real Human-Human dialogs. Detecting real emotions should be a clear focus for research on modeling human dialog, as it could help with analyzing the evolution of the dialog. Our aims are to define appropriate emotions for call center services, to validate the presence of emotions via perceptual tests and to find robust cues for emotion detection. Most research has focused mainly on artificial data in which predefined-emotions were simulated by actors. For real-life corpora a set of appropriate emotion labels must be determined. To this purpose, we conducted a perceptual test exploring 2 experimental conditions: with and without the capacity of listening the audio-signal. Perceived emotions reflect the presence of shaded and mixed emotions/attitudes. We report correlations between objective values and both perceived prosodic parameters and emotion labels.
Identity, Distribution Rules and Productivity in Heterogeneous Teams: An Experiment

This paper examines experimentally the effects of social identity and communication on teams’ distributional rules and wealth creation. The context studied is team production with multiple resource owners of different skills. In these organizational settings, heterogeneity of skills might create a conflict between equity, equality and social welfare. The results of a two-stage experiment, where participants vote in the distributional rule in stage I and make their effort decisions in stage II, indicate that induced group identity prompts preferences for equality even at the expense of wealth creation. We find that compared to a setting where social interaction is absent, identity does not increase team productivity, but equalizes individual payoffs. These findings suggest that group identity triggers the wide spread use of equal sharing rules by heterogeneous teams, as it increases the team’s level of egalitarianism. This paper provides recommendations for organizational decision-making.
Disparate Impact of Butyroyloxymethyl Diethylphosphate (AN-7), a Histone Deacetylase Inhibitor, and Doxorubicin in Mice Bearing a Mammary Tumor

The histone deacetylase inhibitor (HDACI) butyroyloxymethyl diethylphosphate (AN-7) synergizes the cytotoxic effect of doxorubicin (Dox) and anti-HER2 on mammary carcinoma cells while protecting normal cells against their insults. This study investigated the concomitant changes occurring in heart tissue and tumors of mice bearing a subcutaneous 4T1 mammary tumor following treatment with AN-7, Dox, or their combination. Dox or AN-7 alone led to inhibition of both tumor growth and lung metastases, whereas their combination significantly increased their anticancer efficacy and attenuated Dox- toxicity. Molecular analysis revealed that treatment with Dox, AN-7, and to a greater degree, AN-7 together with Dox increased tumor levels of γH2AX, the marker for DNA double-strand breaks and decreased the expression of Rad51, a protein needed for DNA repair. These events culminated in increased apoptosis, manifested by the appearance of cytochrome-c in the cytosol. In the myocardium, Dox-induced cardiomyopathy was associated with an increase in γH2AX expression and a reduction in Rad51 and MRE11 expression and increased apoptosis. The addition of AN-7 to the Dox treatment protected the heart from Dox insults as was manifested by a decrease in γH2AX levels, an increase in Rad51 and MRE11 expression, and a diminution of cytochrome-c release. Tumor fibrosis was high in untreated mice but diminished in Dox- and AN-7-treated mice and was almost abrogated in AN-7+Dox-treated mice. By contrast, in the myocardium, Dox alone induced a dramatic increase in fibrosis, and AN7+Dox attenuated it. The high expression levels of c-Kit, Ki-67, c-Myc, lo-FGF, and VEGF in 4T1 tumors were significantly reduced by Dox or AN-7 and further attenuated by AN-7+Dox. In the myocardium, Dox suppressed these markers, whereas AN-7+Dox restored their expression. In conclusion, the combination of AN-7 and Dox results in two beneficial effects, improved anticancer efficacy and cardioprotection.
A Multi-Grid Graphical Password Scheme

The vast majority of computer and communication systems use passwords in order to identify users. Unfortunately, in ubiquitous alpha-numeric password schemes, users tend to choose passwords with predictable characteristics, related to how easy they are to remember. To overcome the vulnerabilities of textual passwords, a lot of alternative techniques have been proposed such as visual or graphical login, biometric systems and fingerprint verification. In this paper we focus on graphical password techniques and more specifically we make an extension to the Draw-a-Secret scheme (DAS) proposed by Jermyn et al. (1999). On the simple DAS scheme the user draws a design on a display grid, which is used as the password. Motivating by the fact that users tend to draw lines and shapes on specific areas in the grid, we propose a different multi-grid construction of the DAS technique. By making a survey on a sample of people with different age and technical knowledge, we concluded that this approach increases the password strength, while remaining user-friendly.
Controllable monodisperse multiple emulsions.

Multiple emulsions, in which dispersed drops contain smaller drops inside, are useful in a large number of commercial applications, including chemical synthesis and drug delivery. For many of these applications, it is critical to have control over the size and structure of multiple emulsion systems. The structure of multiple emulsion systems is in this case defined as the number of bubbles contained in each size "level" of larger bubbles.
Device Interconnectivity

In this paper I present an overview of the Universal Plug and Play (UPnP) technology. I start with a technical part describing the main functionality of the UPnP architecture and its protocols. I also outline the current situation on how this technology is utilised by the Digital Living Network Alliance (DLNA) in their guidelines for home consumer electronics. The technical part is followed by a few use cases on how this technology could be used in home network environment. I make the use cases more illustrative by linking them to such electronic equipment that already is available on the market. Finally I give a brief presentation of complementing as well as competing technologies for managing home networks. I also describe why content protection and service personalisation should be regarded as important further work in this area.
Mechanical vocal-tract models for speech dynamics

Arai has developed several physical models of the human vocal tract for education and has reported that they are intuitive and helpful for students of acoustics and speech science. We first reviewed dynamic models, including the sliding three-tube (S3T) model and the flexible-tongue model. We then developed a head-shaped model with a sliding tongue, which has the advantages of both the S3T and flexible-tongue models. We also developed a computer-controlled version of the Umeda & Teranishi model, as the original model was hard to manipulate precisely by hand. These models are useful when teaching the dynamic aspects of speech. Index Terms: vocal-tract model, speech dynamics, speech production, education in acoustics, speech science
Controlling Your Career Destiny: Making Things Happen for You

Organization members need to take the initiative to systematically control their career development to position themselves for advancement in the organization and profession. Striving to reach their full professional potential and being their best should be targets for organization members in pursuit of career development. The concepts of positive psychology, action learning (including elastic thinking and being a “thought leader”), reputation, and impression management will serve organization members well in their career development endeavors and help them to advance within their organization and profession.
Role for granulocyte colony stimulating factor in angiotensin II-induced neutrophil recruitment and cardiac fibrosis in mice.

BACKGROUND Granulocyte colony stimulating factor (G-CSF) is a key mediator of neutrophil infiltration and is profibrotic in the liver, lung, and infarcted heart, but its roles in angiotensin II (Ang II)-induced hypertension and cardiac remodeling have not been fully determined. Thus, we sought to investigate the causal relation of G-CSF to neutrophil recruitment and cardiac fibrosis in C57BL/6J mice. METHODS Hypertension and cardiac fibrosis were induced in wild-type (WT) mice receiving continuous infusion of Ang II (1,500ng/kg/min). After 7 days, heart sections were stained with hematoxylin and eosin, Masson's trichrome, and immunohistochemistry. The mRNA expression of cytokines was detected by real-time polymerase chain reaction analysis. The protein levels were measured by Western blot analysis. RESULTS After Ang II infusion, myocardial G-CSF expression was significantly elevated in the hearts. Moreover, WT mice exhibited increased blood pressure, marked neutrophil accumulation, proinflammatory cytokine expression, reactive oxygen species production, and cardiac fibrosis after 7 days of Ang II infusion. However, administration of anti-G-CSF neutralizing antibody, but not with control immunoglobulin G, significantly attenuated these effects. In addition, neutralizing G-CSF antibody reversed Ang II-induced activation of ERK1/2, STAT3, and AKT signaling pathways in the hearts. CONCLUSIONS This study demonstrates that G-CSF plays a critical role in hypertension and cardiac fibrosis and targeting this cytokine may be a novel therapeutic strategy to ameliorate hypertensive heart disease.
Selection of Sporting Goods with Vague Set

As a sunrise industry, sporting goods industry is rapid growth in E-commerce. Information overload become an important issue in this situation. Recommendation system is a good way to solve this problem. In order to find a recommendation strategy for sporting goods in E-commerce, Vague Sets, Gaussian function and characteristics of uncertainty were used to represent sporting goods features with Vague value in this paper. On this basis, the general steps of recommendation strategy with Vague Sets were given, in order to get a new idea and method to decision-maker. Finally, recommender formula is given, which will be conducive to the work of the actual recommendation strategy.
Control of blood flow in the cat spinal cord.

Spinal cord blood flow (SCBF) and the effect of end-tidal CO2 concentration (ETCO2) on SCBF (CO2 reactivity) were studied in the lumbar spinal cord of cats by means of the hydrogen-clearance technique Hydrogen gas was administered by inhalation, and its level in spinal cord tissue was estimated amperometrically with small (75 micrometers) platinum electrodes. The average SCBF's at normocapnia (ETCO2 = 4%) of the ventral horn gray matter and of the white matter at several locations were 43.2 and 16.2 ml . 100 gm-1 . min-1, respectively. For gray and white matter, the values of CO2 reactivity, estimated by the coefficient of the regression of SCBF (ml . 100 gm-1 . min-1) on ETCO2 (ml . 100 ml-1) were 11.6 and 2.1, respectively. No differences in SCBF or CO2 reactivity were observed between intact animals kept under N2O-O2 ventilation and decerebrated animals with no anesthesia. After an acute spinal section, ventral horn SCBF and CO2 reactivity (measured eight segments below the cordotomy) were not altered, in spite of the profound neural depression present (that is, spinal shock). Orthodromic (dorsal root) stimulation of the ventral horn neurons induced an average increase in blood flow of 128% above control values. Antidromic (ventral root) motoneuron activation failed to produce any significant changes in ventral horn blood flow.
O envolvimento entre família-escola de pré-escolares com deficiência, dificuldades escolares e desenvolvimento típico

In aim to compare and discuss family-school involvement, this study had the participation of 87 family members, of wich 27 had children with disabilities, 30 with signs of school difficulties and 30 with typical development. Quantitative data were analyzed using descriptive methods – measures of central tendency and dispersion, along with the ANOVA test to comparison between the groups. The results suggested that the preschools these children attended were related differently to each of their families, assuming the best interactions were were those with typical development. The other two groups showed a superficial engage, especially those with of signs of school difficulties.
Multivariate Imaging Genetics Study of MRI Gray Matter Volume and SNPs Reveals Biological Pathways Correlated with Brain Structural Differences in Attention Deficit Hyperactivity Disorder

Background Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder affecting children, adolescents, and adults. Its etiology is not well understood, but it is increasingly believed to result from diverse pathophysiologies that affect the structure and function of specific brain circuits. Although one of the best-studied neurobiological abnormalities in ADHD is reduced fronto-striatal-cerebellar gray matter (GM) volume, its specific genetic correlates are largely unknown. Methods In this study, T1-weighted MR images of brain structure were collected from 198 adolescents (63 ADHD-diagnosed). A multivariate parallel independent component analysis (Para-ICA) technique-identified imaging genetic relationships between regional GM volume and single nucleotide polymorphism data. Results Para-ICA analyses extracted 14 components from genetic data and 9 from MR data. An iterative cross-validation using randomly chosen subsamples indicated acceptable stability of these ICA solutions. A series of partial correlation analyses controlling for age, sex, and ethnicity revealed two genotype–phenotype component pairs significantly differed between ADHD and non-ADHD groups, after a Bonferroni correction for multiple comparisons. The brain phenotype component not only included structures frequently found to have abnormally low volume in previous ADHD studies but was also significantly associated with ADHD differences in symptom severity and performance on cognitive tests frequently found to be impaired in patients diagnosed with the disorder. Pathway analysis of the genotype component identified several different biological pathways linked to these structural abnormalities in ADHD. Conclusion Some of these pathways implicate well-known dopaminergic neurotransmission and neurodevelopment hypothesized to be abnormal in ADHD. Other more recently implicated pathways included glutamatergic and GABA-eric physiological systems; others might reflect sources of shared liability to disturbances commonly found in ADHD, such as sleep abnormalities.
Modeling and Reasoning Upon Facebook Privacy Settings

Understanding the way information is propagated and made visible on Facebook is a difficult task. The privacy settings and the rules that apply to individual items are reasonably straightforward. However, for the user to track all of the information that needs to be integrated and the inferences that can be made on their posts is complex, to the extent that it is almost impossible for any individual to achieve. In this demonstration, we investigate the use of knowledge modeling and reasoning techniques (including basic ontological representation, rules and epistemic logics) to make these inferences explicit to the user.
Design and Implementation of Child Activity Recognition , Drug Interaction Detection and Update of Drug Allergies

In this paper we describe the method of recognition of a child activity of both sexes up to the age of 16 to 29 months by using 3-axis accelerometer on a waist of the body to prevent child accidents such as unintentional injuries at home. Child activities are classified into 6 daily activities which are rolling, standing still, sitting down, walking, toddling, crawling. Medication errors are a leading cause of death worldwide hence hospitals are continuously trying to improve methods and strategies to prevent medication errors. NFC reader and an NFC application is used to detect and update drug allergies and drug interactions for people with multi-morbidity at the time of medication administration.
Comprehensive insights into Mycobacterium tuberculosis DevR (DosR) regulon activation switch

DevR regulon function is believed to be crucial for the survival of Mycobacterium tuberculosis during dormancy. In this study, we undertook a comprehensive analysis of the DevR regulon. All the regulon promoters were assigned to four classes based on the number of DevR binding sites (Dev boxes). A minimum of two boxes are essential for complete interaction and their tandem arrangement is an architectural hallmark at all promoters. Initial interaction of DevR with the conserved box is essential for its cooperative binding to adjacent sites bearing low to very poor sequence conservation and is the universal mechanism underlying DevR-mediated transcriptional induction. The functional importance of tandem arrangement was established by analyzing promoter variants harboring Dev boxes with altered spacing. Conserved sequence logos were generated from 47 binding sequences which included 24 newly discovered Dev boxes. In each half site of an 18-bp binding motif, G5 and C7 are essential for DevR binding. Finally, we show that DevR regulon induction occurs in a temporal manner and genes that are induced early are also usually powerfully induced. The information theory-based approach along with binding and temporal expression studies provide us with comprehensive insights into the complex pattern of DevR regulon activation.
A Survey of Multi-faceted Graph Visualization

Graph visualization is an important ﬁeld in information visualization that is centered on the graphical display of graph-structured data. Yet real world data is rarely just graph-structured, but instead exhibits multiple facets, such as multivariate attributes, or spatial and temporal frames of reference. In an effort to display different facets of a graph, such a wealth of visualization techniques has been developed in the past that current surveys focus on a single additional facet only in order to enumerate and classify them. This report builds on existing graph visualization surveys for the four common facets of partitions, attributes, time, and space. It contributes a generic high-level categorization of faceted graph visualization that subsumes the existing classiﬁcations, which can be understood as facet-speciﬁc reﬁnements of the resulting categories. Furthermore, it extends beyond existing surveys by applying the same categorization to graph visualizations with multiple facets. For each of the introduced categories and considered facets, this overview provides visualization examples to illustrate instances of their realization.
Solving Substitution Ciphers with Combined Language Models

We propose a novel approach to deciphering short monoalphabetic ciphers that combines both character-level and word-level language models. We formulate decipherment as tree search, and use Monte Carlo Tree Search (MCTS) as a fast alternative to beam search. Our experiments show a significant improvement over the state of the art on a benchmark suite of short ciphers. Our approach can also handle ciphers without spaces and ciphers with noise, which allows us to explore its applications to unsupervised transliteration and deniable encryption.
Lineage-restricted retention of a primitive immunoglobulin heavy chain isotype within the Dipnoi reveals an evolutionary paradox

The lineage leading to lungfishes is one of the few major jawed vertebrate groups in which Ig heavy chain isotype structure has not been investigated at the genetic level. In this study, we have characterized three different Ig heavy chain isotypes of the African lungfish, Protopterus aethiopicus, including an IgM-type heavy chain and short and long forms of non-IgM heavy chains. Northern blot analysis as well as patterns of VH utilization suggest that the IgM and non-IgM isotypes are likely encoded in separate loci. The two non-IgM isotypes identified in Protopterus share structural features with the short and long forms of IgX/W/NARC (referred to hereafter as IgW), which were previously considered to be restricted to the cartilaginous fish. It seems that the IgW isotype has a far broader phylogenetic distribution than considered originally and raises questions with regard to the origin and evolutionary divergence of IgM and IgW. Moreover, its absence in other gnathostome lineages implies paradoxically that the IgW-type genes were lost from teleost and tetrapod lineages.