Miracle-dz/UniFAR-FTUs huggingface dataset:
The QWERTY Effect: How stereo-typing shapes the mental lexicon

The QWERTY keyboard mediates communication for millions of language users. Here we investigated whether differences in the way words are typed correspond to differences in their meanings. Some words are spelled with more letters on the right side of the keyboard and others with more letters on the left. We tested whether asymmetries in the way people interact with keys on the right and left of the keyboard influence their evaluations of the emotional valence of the words. In Experiment 1, we found a relationship between emotional valence and QWERTY key position, across three languages (English, Spanish, and Dutch). Words with more right-hand letters were rated as more positive in meaning on average than words with more left-hand letters. In Experiment 2 we replicated this pattern in nonce words. Although these data are correlational, the fact that a similar pattern was found across languages suggests that the QWERTY keyboard is shaping the meanings of words, as people filter language through their fingers. Widespread typing introduces a new mechanism by which semantic changes in language can arise.
A novel VLSI layout fabric for deep sub-micron applications

Proposes a new VLSI layout methodology which addresses the main problems faced in deep sub-micron (DSM) integrated circuit design. Our layout "fabric" scheme eliminates the conventional notion of power and ground routing on the integrated circuit die. Instead, power and ground are essentially "pre-routed" all over the die. By a clever arrangement of power/ground and signal pins, we almost completely eliminate the capacitive effects between signal wires. Additionally. We get a power and ground distribution network with a very low resistance at any point on the die. Another advantage of our scheme is that the arrangement of conductors ensures that on-chip inductances are uniformly negligible. Finally, characterization of the circuit delays, capacitances and resistances becomes extremely simple in our scheme, and needs to be done only once for a design. We show how the uniform parasitics of our fabric give rise to a reliable and predictable design. We have implemented our scheme using public domain layout software. Preliminary results show that it holds much promise as the layout methodology of choice in DSM integrated circuit design.
Electroacupuncture Inhibits Spinal Interleukin-17 A to Alleviate Inflammatory Pain in a Rat Model

Although acupuncture analgesia has been reported in clinical trials, its mechanisms have been unclear. It was recently reported that spinal astrocytes-produced interleukin-17A (IL-17A) facilitates inflammatory pain. Hypothesizing that electroacupuncture (EA) would suppress inflammation-enhanced IL-17A synthesis to inhibit pain, we induced hyperalgesia, as measured by decreased paw withdrawal latency (PWL) to a noxious thermal stimulus, by subcutaneously injecting complete Freund’s adjuvant (CFA, 0.08 ml, 40 μg Mycobacterium tuberculosis) into the hind paws of rats, or intrathecal (i.t.) IL-17A (400 ng in 10 μl) into the lumbar spinal cord. We then gave EA at acupoint GB30 for two 20-min periods, once immediately after CFA or IL-17A administration and again 2 h post-injection. For sham control, EA needles were inserted into GB30 without stimulation. PWL was measured before and 2.5 and 24 h after injection. Spinal IL-17A, IL-17 receptor A (IL-17RA), and phosphorylated NR1, an essential subunit of the N-methyl D-aspartate receptor (NMDAR), were determined 24 h post-CFA or –IL-17A using immunohistochemistry and western blot. Compared to sham control, EA inhibited CFA-caused thermal hyperalgesia 2.5 and 24 h post-CFA and concurrently suppressed inflammation-enhanced IL-17A and IL-17RA synthesis and NR1 phosphorylation in the ipsilateral spinal cord. EA inhibited IL-17A-produced thermal hyperalgesia, IL-17RA synthesis and NR1 phosphorylation. Our data suggest that EA inhibits inflammatory pain by blocking spinal IL-17A synthesis. Since previous study shows that IL-17A is located in astrocytes and IL-17RA and NR1 are in neurons, the data suggest that EA alleviates pain by modulating glia-neuronal interactions that involve IL-17A, IL-17RA, and NR1 phosphorylation.
NOTCH1 activation clinically antagonizes the unfavorable effect of PTEN inactivation in BFM-treated children with precursor T-cell acute lymphoblastic leukemia

Despite improvements in treatment results for pediatric T-cell acute lymphoblastic leukemia, approximately 20% of patients relapse with dismal prognosis. PTEN inactivation and NOTCH1 activation are known frequent leukemogenic events but their effect on outcome is still controversial. We analyzed the effect of PTEN inactivation and its interaction with NOTCH1 activation on treatment response and long-term outcome in 301 ALL-BFM treated children with T-cell acute lymphoblastic leukemia. We identified PTEN mutations in 52 of 301 (17.3%) of patients. In univariate analyses this was significantly associated with increased resistance to induction chemotherapy and a trend towards poor long-term outcome. By contrast, patients with inactivating PTEN and activating NOTCH1 mutations showed marked sensitivity to induction treatment and excellent long-term outcome, which was similar to patients with NOTCH1 mutations only, and more favorable than in patients with PTEN mutations only. Notably, in the subgroup of patients with a prednisone- and minimal residual disease (MRD)-response based medium risk profile, PTEN-mutations without co-existing NOTCH1-mutations represented an MRD-independent highly significant high-risk biomarker. Mutations of PTEN highly significantly indicate a poor prognosis in T-ALL patients who have been stratified to the medium risk group of the BFM-protocol. This effect is clinically neutralized by NOTCH1 mutations. Although these results have not yet been explained by an obvious molecular mechanism, they contribute to the development of new molecularly defined stratification algorithms. Furthermore, these data have unexpected potential implications for the development of NOTCH1 inhibitors in the treatment of T-cell acute lymphoblastic leukemia in general, and in those with a combination of PTEN and NOTCH1 mutations in particular.
Correlation of motor skill, mental rotation, and working memory in 3- to 6-year-old children

A relationship between motor processes and mental rotation has been suggested by current research; however, the influence of working memory on this relationship has not yet been determined. Therefore, a correlation between motor tests, paper–pencil and chronometric mental rotation tests, and working memory tests were conducted in 3- to 6-year-old children. A stepwise multiple-regression showed that 55.5% of the variance was explained by the working memory tests: digit span forward and Corsi forward. This indicates that working memory and executive functions may play an important role in mental rotation and motor processes.
Animal-assisted therapy for dementia: a review of the literature

Background: Animal-assisted therapy (AAT) is gaining popularity as part of therapy programs in residential aged care facilities. Humans and pet dogs respond to quiet interaction with a lowering of blood pressure and an increase in neuroche-micals associated with relaxation and bonding. These effects may be of benefit in ameliorating behavioral and psychological symptoms of dementia (BPSD). Methods: Medline, PsychInfo and CINAHL databases (1960–2005) were searched for papers on AAT or pets and dementia. Publications of controlled trials that measured the effect of AAT for dementia were reviewed. Results: Several small studies suggest that the presence of a dog reduces aggression and agitation, as well as promoting social behavior in people with dementia. One study has shown that aquaria in dining rooms of dementia care units stimulate residents to eat more of their meals and to gain weight but is limited by the small number of facilities studied. There is preliminary evidence that robotic pets may provide pleasure and interest to people with dementia. Conclusions: Current literature suggests that AAT may ameliorate BPSD, but the duration of the beneficial effect has not been explored. The relative benefits of “resident” versus “visiting” pet dogs are unclear and are confounded by the positive effect of pet interaction on staff or caregivers. Further research on the potential benefits of AAT is recommended.
Effect of frequent laser irradiation on orthodontic pain. A single-blind randomized clinical trial.

OBJECTIVE To analyze the effect of low-level laser therapy (LLLT) on perception of pain after separator placement and compare it with perceptions of control and placebo groups using a frequent irradiation protocol. MATERIALS AND METHODS Eighty-eight patients were randomly allocated to a laser group, a light-emitting diode (LED) placebo group, or a control group. Elastomeric separators were placed on the first molars. In the laser and LED groups, first molars were irradiated for 30 seconds every 12 hours for 1 week using a portable device. Pain was marked on a visual analog scale at predetermined intervals. Repeated measure analysis of variance was performed for statistical analysis. RESULTS The pain scores of the laser group were significantly lower than those of the control group up to 1 day. The pain scores in the LED group were not significantly different from those of the laser group during the first 6 hours. After that point, the pain scores of the LED group were not significantly different from those of the control. CONCLUSIONS Frequent LLLT decreased the perception of pain to a nonsignificant level throughout the week after separator placement, compared with pain perception in the placebo and control groups. Therefore, LLLT might be an effective method of reducing orthodontic pain.
Mobile Heart-rate Monitor and Arrhythmia Detection

Integration of mobile technologies and healthcare informatics sets the stage for the innovative emerging research discipline called Mobile Health. Mobile Health includes a wide variety of applications for preventive healthcare, fitness, disease diagnosis and monitoring. One application area is heart-rate monitoring using mobile camera. This application area is based on signal processing. In this study, mobile heart-rate monitor is examined. The Red-based Contactless Heart-rate Detection Algorithm is proposed and application results are presented. Arrhythmia detection capabilities are discussed.
The Acquisition of Sociolinguistic Competence in a Lingua Franca Context

In a world where an increasing amount of communication takes place online, this study presents data from email exchanges to provide the first examination of sociolinguistic competence and the acquisition of native-like variability in an English as a Lingua Franca (ELF) context. The data provided by online interactions between Swiss speakers (with German, French and Italian mother tongues) and the analysis of the specific variables of futurity, relatives, complementizers and adverbials allow the reader to gain a greater understanding of which linguistic features are source language-related and which are learning-related. This book will be of interest to postgraduates and researchers interested in language variation and change, ELF and second language acquisition, as well as to undergraduates wanting guidance on different ways of examining sociolinguistic variables.
A process perspective on psychological contract change: Making sense of, and repairing, psychological contract breach and violation through employee coping actions

Summary Psychological contracts are dynamic, but few studies explore the processes driving change and how employees influence them. By adopting a process approach with a teleological change lens, and drawing upon the sensemaking and coping literatures, this study positions individuals as active and adaptive agents driving contract change. Employing a mixed methodology, with a four-wave longitudinal survey (n = 107 graduate newcomers) and qualitative interviews (n = 26 graduate newcomers), the study focuses on unfolding events and develops an “adaptive remediation” process model aimed at unraveling contract dynamics. The model demonstrates how breach or violation events trigger sensemaking, resulting in initially negative employee reactions and a “withdrawal” of perceived contributions, before individuals exercise their agency and enact coping strategies to make sense of, and adapt and respond to, these discrepancies. A process of contract “repair” could then occur if the coping actions (termed “remediation effects”) were effective, with individuals returning to positive exchange perceptions. These actions either directly addressed the breach and repaired both it and the psychological contract (termed “remedies”) or involved cognitive reappraisal of the broader work environment and repaired the contract but not the breach (termed “buffers”). The results highlight the unfolding, processual nature of psychological contracting. Copyright © 2015 John Wiley & Sons, Ltd.
Atorvastatin improves tubular status in non-diabetic patients with chronic kidney disease - placebo controlled, randomized, cross-over study.

BACKGROUND There is evidence that dyslipidemia is associated with chronic kidney disease (CKD) and it has been implicated in the progression of renal damage. Optimal management of dyslipidemia should therefore lead to renal benefits. A number of experimental models demonstrate a beneficial effect of statins in ameliorating renal damage. However, the exact mechanism by which statins protect against renal damage remains unclear. METHODS In a placebo-controlled, randomized, cross-over study we evaluated the influence of atorvastatin (ATO) 40 mg/day added to the renin-angiotensin-aldosterone systeme (RAAS) blockade on proteinuria and surrogate biomarkers of tubular damage or injury in 14 non-diabetic patients with proteinuria (0.4-1.8 g per 24 h) with normal or declined kidney function (eGFR 55-153 ml/min). In the eight-week run-in period, therapy using angiotensin converting enzyme inhibitors (ACEI) and/or angiotensin II subtype 1 receptor antagonists (ARB) was adjusted to achieve a blood pressure below 130/80 mm Hg. Next, patients were randomly assigned to one of two treatment sequences: ATO/washout/placebo or placebo/washout/ATO. Clinical evaluation and laboratory tests were performed at the randomization point and after each period of the study. The primary end point of this study was a change in proteinuria measured as 24-h urine protein excretion (DPE). Secondary end points included urine N-acetyl-β-D-glucosaminidase (NAG) and α1-microglobulin (α1m) excretion. RESULTS The ATO therapy significantly reduced urine excretion of α₁m (p=0.033) and NAG (p=0.038) as compared to placebo. There were no differences in proteinuria, blood pressure, eGFR and serum creatinine between the ATO and placebo groups. CONCLUSION Atorvastatin treatment is safe and improves biomarkers of tubular damage or injury in non-diabetic patients with CKD.
Visual Management Studies: Empirical and Theoretical Approaches

The field of visual research in management studies is developing rapidly and has reached a point of maturity where it is useful to bring together and evaluate existing work in this area and to critically assess its current impact and future prospects. Visual research is broadly defined to encompass a variety of forms, including pictures, graphs, film, web pages and architecture. It also incorporates work from several sub-disciplines (organization studies, marketing, accounting, human resources, tourism and IT), and includes research based on pre-existing visual material and studies that use researcher-generated visual data. The authors begin by considering the growing recognition of the visual turn in management research as a counterweight to the linguistic turn, while also discussing reasons for resistance to visual approaches. Next, they review research that uses visual methods to study management and organization and suggest that visual management studies may be categorized according to whether methods used are empirically driven or theory based. This categorization highlights the philosophical, theoretical and interdisciplinary underpinnings of visual management studies. It also enables the visual to be accorded a status equivalent to linguistic meaning, through dispelling the realist assumptions that have impeded analytical development of visual management studies to date.
PheKB: a catalog and workflow for creating electronic phenotype algorithms for transportability

OBJECTIVE Health care generated data have become an important source for clinical and genomic research. Often, investigators create and iteratively refine phenotype algorithms to achieve high positive predictive values (PPVs) or sensitivity, thereby identifying valid cases and controls. These algorithms achieve the greatest utility when validated and shared by multiple health care systems.Materials and Methods We report the current status and impact of the Phenotype KnowledgeBase (PheKB, http://phekb.org), an online environment supporting the workflow of building, sharing, and validating electronic phenotype algorithms. We analyze the most frequent components used in algorithms and their performance at authoring institutions and secondary implementation sites. RESULTS As of June 2015, PheKB contained 30 finalized phenotype algorithms and 62 algorithms in development spanning a range of traits and diseases. Phenotypes have had over 3500 unique views in a 6-month period and have been reused by other institutions. International Classification of Disease codes were the most frequently used component, followed by medications and natural language processing. Among algorithms with published performance data, the median PPV was nearly identical when evaluated at the authoring institutions (n = 44; case 96.0%, control 100%) compared to implementation sites (n = 40; case 97.5%, control 100%). DISCUSSION These results demonstrate that a broad range of algorithms to mine electronic health record data from different health systems can be developed with high PPV, and algorithms developed at one site are generally transportable to others. CONCLUSION By providing a central repository, PheKB enables improved development, transportability, and validity of algorithms for research-grade phenotypes using health care generated data.
Advances in Medical Education and Practice Dovepress Medical Students-as-teachers: a Systematic Review of Peer-assisted Teaching during Medical School

Introduction: International interest in peer-teaching and peer-assisted learning (PAL) during undergraduate medical programs has grown in recent years, reflected both in literature and in practice. There, remains however, a distinct lack of objective clarity and consensus on the true effectiveness of peer-teaching and its short-and long-term impacts on learning outcomes and clinical practice. Objective: To summarize and critically appraise evidence presented on peer-teaching effectiveness and its impact on objective learning outcomes of medical students. Method: A literature search was conducted in four electronic databases. Titles and abstracts were screened and selection was based on strict eligibility criteria after examining full-texts. Two reviewers used a standard review and analysis framework to independently extract data from each study. Discrepancies in opinions were resolved by discussion in consultation with other reviewers. Adapted models of " Kirkpatrick's Levels of Learning " were used to grade the impact size of study outcomes. Results: From 127 potential titles, 41 were obtained as full-texts, and 19 selected after close examination and group deliberation. Fifteen studies focused on student-learner outcomes and four on student-teacher learning outcomes. Ten studies utilized randomized allocation and the majority of study participants were self-selected volunteers. Written examinations and observed clinical evaluations were common study outcome assessments. Eleven studies provided student-teachers with formal teacher training. Overall, results suggest that peer-teaching, in highly selective contexts, achieves short-term learner outcomes that are comparable with those produced by faculty-based teaching. Furthermore, peer-teaching has beneficial effects on student-teacher learning outcomes. Conclusions: Peer-teaching in undergraduate medical programs is comparable to conventional teaching when utilized in selected contexts. There is evidence to suggest that participating student-teachers benefit academically and professionally. Long-term effects of peer-teaching during medical school remain poorly understood and future research should aim to address this.
Utilization of hierarchical, stochastic relationship modeling for Hangul character recognition

In structural character recognition, a character is usually viewed as a set of strokes and the spatial relationships between them. Therefore, strokes and their relationships should be properly modeled for effective character representation. For this purpose, we propose a modeling scheme by which strokes as well as relationships are stochastically represented by utilizing the hierarchical characteristics of target characters. A character is defined by a multivariate random variable over the components and its probability distribution is learned from a training data set. To overcome difficulties of the learning due to the high order of the probability distribution (a problem of curse of dimensionality), the probability distribution is factorized and approximated by a set of lower-order probability distributions by applying the idea of relationship decomposition recursively to components and subcomponents. Based on the proposed method, a handwritten Hangul (Korean) character recognition system is developed. Recognition experiments conducted on a public database show the effectiveness of the proposed relationship modeling. The recognition accuracy increased by 5.5 percent in comparison to the most successful system ever reported.
Transformational Leadership Manifestation in a Group of Puertorrican Supervisors

This research was carried out to identify the leadership style which is largely self-attributed by a group of Puertorrican supervisors. Similarly, we would compare if these selfattributions were significantly different between women and men. A total of 200 supervisors participated in this study, 112 women and 88 men. The results support the applicability of the full-range theory of leadership in the Puertorrican leaders. We identified significant differences when comparing the self-attributions of supervisors, showing women higher levels of transformational and transactional leadership when compared with men. No significant differences were found when considering other relevant demographic variables, nor an interaction of these with the gender of the supervisor. These results are discussed according to findings in other studies outside of Puerto Rico and its implications in our country.