Miracle-dz/UniFAR-FTUs huggingface dataset:
Use of antipsychotics in the treatment of depressive disorders

Summary There is a long history of using antipsychotic medications in the treatment of depressive disorders. Atypical antipsychotics, which have fewer side effects than traditional antipsychotics, have been used as monotherapy or adjunctively with antidepressants to treat depressive disorders with or without psychotic symptoms. The antidepressant effect of atypical antipsychotics involves regulation of monoamine, glutamate, gamma-aminobutyric acid (GABA), cortisol, and neurotrophic factors. To date, the United States Food and Drug Administration (USFDA) has approved aripiprazole and quetiapine slow-release tablets as adjunctive treatment for depressive disorders, and the combination of olanzapine and fluoxetine for the treatment of treatment-resistant depression. When using atypical antipsychotics in the treatment of depressed patients, clinicians need to monitor patients for the emergence of adverse effects including extrapyramidal symptoms (EPS), weight gain, and hyperglycemia.
Fertility and Weed Stress Effects on Performance of Maize/Soybean Intercrop

Intercropped corn (Zea mays L.) and soybean [Glycine max (L.) Merr. ] may produce more total yield per hectare than either grown separately, ie. , land equivalent ratio (LER)>1. Low N fertility, limited moisture, and weed competition have each been reported to result in high land equivalent ratios. Thus it was hypothesized that intercropping advantages were greater under stress conditions. The objectives were to study the effects to soil fertility stress (F 1 =low N-P-K, F 2 =high N-P-K), weed competition stress (W 1 =unweeded, W 2 weeded), and four cropping systems (M 2 S, M 1 S, M 2 , S ; where M 2 =high density maize, M 1 =low density maize, and S=soybean at normal density) on the performance of maize and soybean, and on the growth of weeds (.)
Cell-Mediated Immune Response to Human Papillomavirus Infection

Acquisition of human papillomavirus (HPV) results in an infection of variable duration which may or may not be associated with clinically apparent lesions. Lesions caused by skintropic HPV types generally manifest as cutaneous warts and most often resolve over a period of months to years. On the other hand, anogenital infections are more likely to remain clinically inapparent. The development of DNA amplificationbased tests has demonstrated that anogenital infections are quite common and generally self-limited. For example, we and others have shown by PCR testing of multiple samples collected at different points in time-that 70 to 90% of sexually active adolescents and young women who develop an incident cervical HPV infection will show clearance of infection within 12 to 30 months (47, 61, 94). The factors influencing the natural history of these infections are not well understood. Given that persistent anogenital infection with oncogenic HPV types is associated with increased risk of neoplasia and invasive cancers (22, 59, 70, 71, 94, 124) and that cervical carcinoma remains a leading cause of death among women in developing countries (129), understanding these factors is of considerable importance. Substantial effort has been directed recently at understanding the role of the host’s immune response in the natural history of HPV, and in particular, anti-viral, cell-mediated immunity. Empirical evidence for the importance of cell-mediated immunity in control of HPV infection comes from an extensive body of literature documenting the increased prevalence of HPV infection and associated disease among immunosuppressed populations, including those with iatrogenic immunosuppression such as renal transplant recipients and individuals with human immunodeficiency virus (HIV) infection. Sillman and coauthors (128) reported in 1984 on 20 immunosuppressed women with various causes of immunosuppression who had lower genital neoplasia, describing evidence of associated HPV infection in all 20. Penn, in 1986, reported a 100-fold increase in cancer of the vulva and anus in renal transplant recipients (111). In the 1990s, as molecular testing for HPV infection came into its own, several reports confirmed increased incidence of HPV infection (50) and associated morbidities, including warts (77) and cervical squamous intraepithelial lesions (SIL) (104), among immunosuppressed renal
A data dictionary/directory system within the context of an integrated corporate data base

The evolution of commercial business applications has gone from simple repetitive accounting to extremely complex information systems, and has been characterized by decentralized control of data. Most corporations began their automation efforts by computerizing the repetitive operations of the clerk and bookkeeper. These may be referred to as Accounting or Operational Level Systems. With the advent of second and third generation hardware and software, it became feasible to collect relevant Accounting Level Systems under a functional umbrella and to relate these applications in some manner or means with the objective of providing management with a slightly broader scope of information about the business operation. Systems supporting this level of information can be termed Functional Level Systems. In the banking environment this has manifested itself in information systems (sometimes labeled MIS) dedicated, for example, to Deposits or Loans. These systems contain within them subsystems which are in essence Accounting Level Systems, such as Demand Deposit Accounting or Installment Loans.
A hierarchical indexing strategy for optimizing Apache Spark with HDFS to efficiently query big geospatial raster data

ABSTRACT Earth observations and model simulations are generating big multidimensional array-based raster data. However, it is difficult to efficiently query these big raster data due to the inconsistency among the geospatial raster data model, distributed physical data storage model, and the data pipeline in distributed computing frameworks. To efficiently process big geospatial data, this paper proposes a three-layer hierarchical indexing strategy to optimize Apache Spark with Hadoop Distributed File System (HDFS) from the following aspects: (1) improve I/O efficiency by adopting the chunking data structure; (2) keep the workload balance and high data locality by building the global index (k-d tree); (3) enable Spark and HDFS to natively support geospatial raster data formats (e.g., HDF4, NetCDF4, GeoTiff) by building the local index (hash table); (4) index the in-memory data to further improve geospatial data queries; (5) develop a data repartition strategy to tune the query parallelism while keeping high data locality. The above strategies are implemented by developing the customized RDDs, and evaluated by comparing the performance with that of Spark SQL and SciSpark. The proposed indexing strategy can be applied to other distributed frameworks or cloud-based computing systems to natively support big geospatial data query with high efficiency.
Competitive Auctions

We study a class of single-round, sealed-bid auctions for an item in unlimited supply, such as a digital good. We introduce the notion of competitive auctions. A competitive auction is truthful (i.e. encourages bidders to bid their true valuations) and on all inputs yields profit that is within a constant factor of the profit of the optimal single sale price. We justify the use of optimal single price profit as a benchmark for evaluating a competitive auctions profit. We exhibit several randomized competitive auctions and show that there is no symmetric deterministic competitive auction. Our results extend to bounded supply markets, for which we also give competitive auctions. and digital goods. The new paper contains new results and refines some of the results and concepts introduced in the preliminary version.
Interactive Visualization and Navigation of Complex Terminology Systems, Exemplified by SNOMED CT

Free-text queries are natural entries into the exploration of complex terminology systems. The way search results are presented has impact on the user's ability to grasp the overall structure of the system. Complex hierarchies like the one used in SNOMED CT, where nodes have multiple parents (IS-A) and several other relationship types, makes visualization challenging. This paper presents a prototype, TermViz, applying well known methods like "focus+context" and self-organizing layouts from the fields of Information Visualization and Graph Drawing to terminologies like SNOMED CT and ICD-10. The user can simultaneously focus on several nodes in the terminologies and then use interactive animated graph navigation and semantic zooming to further explore the terminology systems without loosing context. The prototype, based on Open Source Java components, demonstrates how a number of Information Visualisation methods can aid the exploration of medical terminologies with millions of elements and can serve as a base for further development.
The Joint Task Force on Computing Curricula IEEE Computer Society Association for Computing Machinery

The number, size, and application domains of computer programs have grown dramatically; as a result, hundreds of billions are being spent on software development, and the livelihood and lives of most people depend on the effectiveness of this development. Software products have helped us to be more efficient and productive. They make us more effective problem solvers, and they provide us with an environment for work and play that is often safer, more flexible, and less confining. Despite these successes, there are serious problems in the cost, timeliness, and quality of many software products. The reasons for these problems are many and include the following:
Translating effective web-based self-help for problem drinking into the real world.

BACKGROUND Drinking Less (DL) is a 24/7 free-access anonymous interactive web-based self-help intervention without therapeutic guidance for adult problem drinkers in the community. In a randomized controlled trial (referred to here as DL-RCT), DL has been shown effective in reducing risky alcohol consumption. OBJECTIVE To assess whether the findings of DL-RCT are generalizable to a naturalistic setting (DL-RW) in terms of ability to reach the target group and alcohol treatment response. METHODS Pretest-posttest study with 6-month follow-up. An online survey was conducted of 378 of the 1,625 people who used DL-RW from May to November 2007. Primary outcome measures were (1) problem drinking, defined as alcohol consumption in the previous 4 weeks averaging >21 or >14 standard units (male/female) per week or >or=6 or >or=4 units (m/f) on 1 or more days per week; and (2) mean weekly alcohol consumption. DL-RW and DL-RCT data were compared and pooled. Intention-to-treat (ITT) analysis was performed to analyze and compare changes in drinking from baseline to follow-up. RESULTS In the DL-RW group, 18.8% (n = 71) were drinking successfully within the limits of the Dutch guideline for low-risk drinking (p < 0.001) 6 months after baseline (ITT). The DL-RW group also decreased its mean weekly alcohol intake by 7.4 units, t(377) = 6.67, p < 0.001, d = 0.29. Drinking reduction in DL-RW was of a similar magnitude to that in the DL-RCT condition in terms of drinking within the guideline [chi(2)(1) = 1.83, CI: 0.82-3.00, p = 0.18, RD = 0.05, OR = 1.55] and mean weekly consumption (a negligible difference of d = 0.03 in favor of DL-RW group). CONCLUSION The results from DL-RCT and DL-RW were similar, and they demonstrate that web-based self-help without therapeutic guidance is feasible, well accepted, and effective for curbing adult problem drinking in the community.
Recovery of Missing Samples from Oversampled Bandpass Signals and Its Stability

We present a multi-channel sampling expansion for signals with selectively tiled band-region. From this we derive an oversampling expansion for any bandpass signal, and show that any finitely many missing samples from two-channel oversampling expansion can always be uniquely recovered. In addition, we find a sufficient condition under which some infinitely many missing samples can be recovered. Numerical stability of the recovery process is also discussed in terms of the oversampling rate and distribution of the missing samples.
Prenatal Vitamin D Supplementation and Child Respiratory Health: A Randomised Controlled Trial

Background Observational studies suggest high prenatal vitamin D intake may be associated with reduced childhood wheezing. We examined the effect of prenatal vitamin D on childhood wheezing in an interventional study. Methods We randomised 180 pregnant women at 27 weeks gestation to either no vitamin D, 800 IU ergocalciferol daily until delivery or single oral bolus of 200,000 IU cholecalciferol, in an ethnically stratified, randomised controlled trial. Supplementation improved but did not optimise vitamin D status. Researchers blind to allocation assessed offspring at 3 years. Primary outcome was any history of wheeze assessed by validated questionnaire. Secondary outcomes included atopy, respiratory infection, impulse oscillometry and exhaled nitric oxide. Primary analyses used logistic and linear regression. Results We evaluated 158 of 180 (88%) offspring at age 3 years for the primary outcome. Atopy was assessed by skin test for 95 children (53%), serum IgE for 86 (48%), exhaled nitric oxide for 62 (34%) and impulse oscillometry of acceptable quality for 51 (28%). We found no difference between supplemented and control groups in risk of wheeze [no vitamin D: 14/50 (28%); any vitamin D: 26/108 (24%) (risk ratio 0.86; 95% confidence interval 0.49, 1.50; P = 0.69)]. There was no significant difference in atopy, eczema risk, lung function or exhaled nitric oxide between supplemented groups and controls. Conclusion Prenatal vitamin D supplementation in late pregnancy that had a modest effect on cord blood vitamin D level, was not associated with decreased wheezing in offspring at age three years. Trial Registration Controlled-Trials.com ISRCTN68645785
Mining search behavior and user-generated content: presentation at the industrial session - EDBT/ICDT 2012

In the first part of this presentation, we will overview two systems that gather and display intelligence from search behavior: "Yahoo! Search Clues" and "Yahoo! Political Insights". In the second part, we will discuss two real-world problems encountered when mining user-generated content: determining which pieces of content are credible, and modeling how users influence each other.
Klebsiella pneumoniae ST258 Producing KPC-3 Identified in Italy Carries Novel Plasmids and OmpK36/OmpK35 Porin Variants

ABSTRACT A carbapenemase-resistant Klebsiella pneumoniae strain, clone ST258 producing KPC-3, was fully characterized. The entire plasmid content was investigated, thereby identifying plasmids of the IncFIIk (two of them similar to pKPQIL and pKPN3, respectively), IncX, and ColE types, carrying a formidable set of resistance genes against toxic compounds, metals, and antimicrobial drugs and a novel iron(III) uptake system.
Drosophila at the intersection of infection, inflammation, and cancer

Recent studies show that both cellular and humoral aspects of innate immunity play important roles during tumor progression. These interactions have traditionally been explored in vertebrate model systems. In recent years, Drosophila has emerged as a genetically tractable model system for studying key aspects of tumorigenesis including proliferation, invasion, and metastasis. The absence of adaptive immunity in Drosophila provides a unique opportunity to study the interactions between innate immune system and cancer in different genetic contexts. In this review, I discuss recent advances made by using Drosophila models of cancer to study the role of innate immune pathways Toll/Imd, JNK, and JAK-STAT, microbial infection and inflammation during tumor progression.
Clinical Significance, Prevalence, and Natural History of Thrombocytopenia in Pregnancy-Induced Hypertension

The purpose of this study was to establish the prevalence and clinical significance of thrombocytopenia in pregnancy-induced hypertension (PIH). Thrombocytopenia, defined as a platelet count less than 100,000/mm3 was found in 11.6% of all patients with PIH. Logistic regression analysis was used to assess the relative contribution of thrombocytopenia, proteinuria, and the degree of hypertension to maternal and perinatal outcome. Thrombocytopenia was the principal contributor to the occurrence of abdominal pain, liver dysfunction, the presence of schistocytes in the peripheral smear, proteinuria, fetal distress, and the requirement for blood transfusions. Thrombocytopenia was also associated with a higher incidence of preterm delivery and intrauterine growth retardation. The nadir platelet count occurred within 48 hours of delivery in 56.7% (21 of 37) of cases. The median number of days for recovery of the thrombocytopenia was 2.0 days (range, 0 to 8 days). In five patients thrombocytopenia preceded the clinical manifestations of PIH. We conclude that thrombocytopenia is an independent and important risk factor for the occurrence of maternal and perinatal complications in PIH.
Berberine induces apoptosis and DNA damage in MG-63 human osteosarcoma cells

Berberine, an isoquinoline alkaloid extracted from the dry root of Coptidis Rhizoma, has been found to exhibit marked anticancer effects on a panel of established cancer cells. Among the human osteosarcoma lines treated, MG-63 cells were found to be the most sensitive. The present study investigated the potential genotoxic effect of berberine on MG-63 human osteosarcoma cells. The effect of berberine on cell viability was determined using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and cell apoptosis was analyzed by flow cytometry and a DNA ladder assay. γH2AX focus formation was used to detect DNA damage in MG-63 cells. Berberine induced a significant increase in apoptosis in MG-63 cells in a concentration- and time-dependent manner, as determined by DNA fragmentation analysis and flow cytometry. Furthermore, berberine induced significant concentration- and time-dependent increases in DNA damage compared with that in the negative control. In conclusion, these observations indicated that berberine induced apoptosis and DNA damage in MG-63 cells.
Quality Assessment of Large Scale Knowledge Resources

This paper presents an empirical evaluation of the quality of publicly available large-scale knowledge resources. The study includes a wide range of manually and automatically derived large-scale knowledge resources. In order to establish a fair and neutral comparison, the quality of each knowledge resource is indirectly evaluated using the same method on a Word Sense Disambiguation task. The evaluation framework selected has been the Senseval-3 English Lexical Sample Task. The study empirically demonstrates that automatically acquired knowledge resources surpass both in terms of precision and recall the knowledge resources derived manually, and that the combination of the knowledge contained in these resources is very close to the most frequent sense classifier. As far as we know, this is the first time that such a quality assessment has been performed showing a clear picture of the current state-of-the-art of publicly available wide coverage semantic resources.
Modeling Sensor Reliability in Fault Diagnosis Based on Evidence Theory

Sensor data fusion plays an important role in fault diagnosis. Dempster–Shafer (D-R) evidence theory is widely used in fault diagnosis, since it is efficient to combine evidence from different sensors. However, under the situation where the evidence highly conflicts, it may obtain a counterintuitive result. To address the issue, a new method is proposed in this paper. Not only the statistic sensor reliability, but also the dynamic sensor reliability are taken into consideration. The evidence distance function and the belief entropy are combined to obtain the dynamic reliability of each sensor report. A weighted averaging method is adopted to modify the conflict evidence by assigning different weights to evidence according to sensor reliability. The proposed method has better performance in conflict management and fault diagnosis due to the fact that the information volume of each sensor report is taken into consideration. An application in fault diagnosis based on sensor fusion is illustrated to show the efficiency of the proposed method. The results show that the proposed method improves the accuracy of fault diagnosis from 81.19% to 89.48% compared to the existing methods.
Genetic and biochemical characterization of mutations in the ATPase and helicase regions of the Upf1 protein

mRNA degradation is an important control point in the regulation of gene expression and has been linked to the process of translation. One clear example of this linkage is the nonsense-mediated mRNA decay pathway, in which nonsense mutations in a gene can reduce the abundance of the mRNA transcribed from that gene. For the yeast Saccharomyces cerevisiae, the Upf1 protein (Upf1p), which contains a cysteine- and histidine-rich region and nucleoside triphosphate hydrolysis and helicase motifs, was shown to be a trans-acting factor in this decay pathway. Biochemical analysis of the wild-type Upf1p demonstrates that it has RNA-dependent ATPase, RNA helicase, and RNA binding activities. A UPF1 gene disruption results in stabilization of nonsense-containing mRNAs, leading to the production of enough functional product to overcome an auxotrophy resulting from a nonsense mutation. A genetic and biochemical study of the UPF1 gene was undertaken in order to understand the mechanism of Upf1p function in the nonsense-mediated mRNA decay pathway. Our analysis suggests that Upf1p is a multifunctional protein with separable activities that can affect mRNA turnover and nonsense suppression. Mutations in the conserved helicase motifs of Upf1p that inactivate its mRNA decay function while not allowing suppression of leu2-2 and tyr7-1 nonsense alleles have been identified. In particular, one mutation located in the ATP binding and hydrolysis motif of Upf1p that changed the aspartic and glutamic acid residues to alanine residues (DE572AA) lacked ATPase and helicase activities, and the mutant formed a Upf1p:RNA complex in the absence of ATP; surprisingly, however, the Upf1p:RNA complex dissociated as a consequence of ATP binding. This result suggests that ATP binding, independent of its hydrolysis, can modulate Upf1p:RNA complex formation for this mutant protein. The role of the RNA binding activity of Upf1p in modulating nonsense suppression is discussed.
Theoretical and Experimental Analysis of Waste Heat Recovery Effectiveness of a Diesel Engine

The study utilized the exhaust gas from a diesel engine to preheat water in the constructed shell and tube heat exchanger. The theoretical analysis of the heat exchanger was carried out using the Log Mean Temperature Difference (LMTD) method. The Volumetric flowrate of the water was manipulated using a valve and the resulting output temperature of water leaving the heat exchanger was recorded. Experimentation was carried out to determine the effects of volumetric flow rate on the output temperature and the effectiveness of the heat exchanger. After the test and data analysis, it was discovered that that at flow rate of 3.0 Liter per minute (LPM) the effectiveness of the heat exchanger was peak at 43.34%. The volumetric flow rate of water is inversely proportional to the output temperature of water and it was also established that the effectiveness of the heat exchanger depends on output temperature of and the mass flow rate of the water. Also it was proven that by preheating water before it enters the boiler of the Rankine cycle the efficiency of the cycle increases.