Miracle-dz/UniFAR-FTUs huggingface dataset:
Lung transplantation

Lung transplantation may be the only intervention that can prolong survival and improve quality of life for those individuals with advanced lung disease who are acceptable candidates for the procedure. However, these candidates may be extremely ill and require ventilator and/or circulatory support as a bridge to transplantation, and lung transplantation recipients are at risk of numerous post-transplant complications that include surgical complications, primary graft dysfunction, acute rejection, opportunistic infection, and chronic lung allograft dysfunction (CLAD), which may be caused by chronic rejection. Many advances in pre- and post-transplant management have led to improved outcomes over the past decade. These include the creation of sound guidelines for candidate selection, improved surgical techniques, advances in donor lung preservation, an improving ability to suppress and treat allograft rejection, the development of prophylaxis protocols to decrease the incidence of opportunistic infection, more effective therapies for treating infectious complications, and the development of novel therapies to treat and manage CLAD. A major obstacle to prolonged survival beyond the early post-operative time period is the development of bronchiolitis obliterans syndrome (BOS), which is the most common form of CLAD. This manuscript discusses recent and evolving advances in the field of lung transplantation.
LIFE EVENTS AND DEPRESSION

SUMMARY The life events occurring in a 6 month period preceding onset of illness in 50 OPD primary depressives were inquired into by a Life Events Inventory and compared with those in a corresponding time period of 50 matched controls. The relation between life events and the depth of depression at initial interview was also studied. The results are analysed and the probable pitfalls discussed.
Vaniprevir with pegylated interferon alpha‐2a and ribavirin in treatment‐naïve patients with chronic hepatitis C: A randomized phase II study

Vaniprevir (MK‐7009) is a macrocyclic hepatitis C virus (HCV) nonstructural protein 3/4A protease inhibitor. The aim of the present phase II study was to examine virologic response rates with vaniprevir in combination with pegylated interferon alpha‐2a (Peg‐IFN‐α‐2a) plus ribavirin (RBV). In this double‐blind, placebo‐controlled, dose‐ranging study, treatment‐naïve patients with HCV genotype 1 infection (n = 94) were randomized to receive open‐label Peg‐IFN‐α‐2a (180 μg/week) and RBV (1,000‐1,200 mg/day) in combination with blinded placebo or vaniprevir (300 mg twice‐daily [BID], 600 mg BID, 600 mg once‐daily [QD], or 800 mg QD) for 28 days, then open‐label Peg‐IFN‐α‐2a and RBV for an additional 44 weeks. The primary efficacy endpoint was rapid viral response (RVR), defined as undetectable plasma HCV RNA at week 4. Across all doses, vaniprevir was associated with a rapid two‐phase decline in viral load, with HCV RNA levels approximately 3log10 IU/mL lower in vaniprevir‐treated patients, compared to placebo recipients. Rates of RVR were significantly higher in each of the vaniprevir dose groups, compared to the control regimen (68.8%‐83.3% versus 5.6%; P < 0.001 for all comparisons). There were numerically higher, but not statistically significant, early and sustained virologic response rates with vaniprevir, as compared to placebo. Resistance profile was predictable, with variants at R155 and D168 detected in a small number of patients. No relationship between interleukin‐28B genotype and treatment outcomes was demonstrated in this study. The incidence of adverse events was generally comparable between vaniprevir and placebo recipients; however, vomiting appeared to be more common at higher vaniprevir doses. Conclusion: Vaniprevir is a potent HCV protease inhibitor with a predictable resistance profile and favorable safety profile that is suitable for QD or BID administration. (HEPATOLOGY 2012;56:884–893)
Palliative care for people with heart failure: Summary of current evidence and future direction

Background: Heart failure is a common condition with a significant physical and psychological burden for patients and their families. The need for supportive and palliative care: It is well recognised that palliative care is important in patients with advanced heart failure. What is known: Heart failure patients have limited access to palliative care services. Barriers to palliative care include difficult prognostication due to the unpredictable disease trajectory and inadequate initiation of conversations about end-of-life care. What is not known: There are gaps in the evidence for symptom control, especially for symptoms other than pain or dyspnoea, but recommendations are becoming increasingly evidence based. Implications for research, policy and practice: There are challenges to research in this area although progress is being made with increasing numbers of trials and use of novel research methods. Integrated models of care based on symptom triggers rather than prognosis are recommended. At the centre is excellent communication both with the patient and between services to ensure the best possible care.
Approximate Range Selection Queries in Peer-to-Peer Systems

We present an architecture for a data sharing peer-to-peer system where the data is shared in the form of database relations. In general, peer-to-peer systems try to locate exactmatch data objects to simple user queries. Since peer-to-peer users generally tend to submit broad queries in order to find data of their interest, we develop a P2P data sharing architecture for computing approximate answers for the complex queries by finding data ranges that are similar to the user query. Thus this paper represents the first step towards solving the general range lookup problem over P2P systems instead of exact lookup operations.
Bone level variation after vertical ridge augmentation: resorbable barriers versus titanium-reinforced barriers. A 6-year double-blind randomized clinical trial.

PURPOSE To compare the efficacy of two different techniques for vertical bone regeneration at implant placement with particulate autogenous bone at 6 years after loading by means of a double-blind, superiority, parallel-group randomized clinical trial. MATERIALS AND METHODS The study was conducted in a private center in Italy between April 2004 and December 2011. Patients in whom vertical bone augmentation was indicated in combination with the placement of single or multiple implants were eligible for inclusion in this trial. Patients were randomized to receive either resorbable collagen barriers supported by an osteosynthesis plate (test group) or nonresorbable titanium-reinforced expanded polytetrafluoroethylene barriers (control group). The outcome variables-radiographic bone variation at implant sites, implant failures, and complications- were evaluated 6 years after loading. Randomization was done by computer, with allocation concealed by opaque sequentially numbered sealed envelopes. The patients and the radiographic examiner were blinded to group assignment. RESULTS Twenty-two patients were randomized: 11 to the resorbable barrier group and 11 to the nonresorbable (control) group. One control group patient dropped out. The mean bone level 6 years after surgery was 1.33 mm for the resorbable group and 1.00 mm for the nonresorbable group. The adjusted difference in bone changes between groups was 0.15 mm (95% confidence interval, -0.39 to 0.69, P = .5713). No implant failures or complications occurred after loading. CONCLUSION No differences were observed in this comparison of resorbable and nonresorbable barriers with simultaneous implant placement for vertical ridge augmentation.
Identification of dystroglycan as a second laminin receptor in oligodendrocytes, with a role in myelination

Developmental abnormalities of myelination are observed in the brains of laminin-deficient humans and mice. The mechanisms by which these defects occur remain unknown. It has been proposed that, given their central role in mediating extracellular matrix (ECM) interactions, integrin receptors are likely to be involved. However, it is a non-integrin ECM receptor, dystroglycan, that provides the key linkage between the dystrophin-glycoprotein complex (DGC) and laminin in skeletal muscle basal lamina, such that disruption of this bridge results in muscular dystrophy. In addition, the loss of dystroglycan from Schwann cells causes myelin instability and disorganization of the nodes of Ranvier. To date, it is unknown whether dystroglycan plays a role during central nervous system (CNS) myelination. Here, we report that the myelinating glia of the CNS, oligodendrocytes, express and use dystroglycan receptors to regulate myelin formation. In the absence of normal dystroglycan expression, primary oligodendrocytes showed substantial deficits in their ability to differentiate and to produce normal levels of myelin-specific proteins. After blocking the function of dystroglycan receptors, oligodendrocytes failed both to produce complex myelin membrane sheets and to initiate myelinating segments when co-cultured with dorsal root ganglion neurons. By contrast, enhanced oligodendrocyte survival in response to the ECM, in conjunction with growth factors, was dependent on interactions with beta-1 integrins and did not require dystroglycan. Together, these results indicate that laminins are likely to regulate CNS myelination by interacting with both integrin receptors and dystroglycan receptors, and that oligodendrocyte dystroglycan receptors may have a specific role in regulating terminal stages of myelination, such as myelin membrane production, growth, or stability.
Cancer risk in patients with Peutz–Jeghers syndrome: A retrospective cohort study of 336 cases

Peutz–Jeghers syndrome is a rare autosomal dominant inherited disorder characterized by mucocutaneous pigmentation and hamartomatous gastrointestinal polyposis. A growing body of evidence has shown that Peutz–Jeghers syndrome could cause an increased risk of various cancers, yet the range of cancer risk estimates was wide among different studies. In this retrospective cohort study, 336 patients with Peutz–Jeghers syndrome in China were enrolled. The clinical characteristics, cancer spectrum, relative cancer risks, and cumulative cancer risks were analyzed. In total, 52 patients were diagnosed of cancer in the follow-up period, at a median age of 41 years (range: 21–67). The relative risk for cancer in Peutz–Jeghers syndrome patients was 63.858 (confidence interval: 47.514–85.823), and the cumulative cancer risk at the age of 60 years was 55%. Colorectal cancer was the most common cancer for Peutz–Jeghers syndrome patients (relative risk: 237.918, confidence interval: 154.417–366.572) and the cumulative cancer risk at the age of 60 years was 28%. There was a statistically significant difference in the cumulative cancer risk between patients with family history and those without family history, as well as between patients living in rural area and those living in urban areas (p < 0.05), while no significant effects of gender and intussusception history on the cumulative cancer risk was found (p > 0.05). Hopefully, our study may contribute to the management of this rare disorder and establishment of related surveillance projects, especially in China.
Understanding the New SQL: A Complete Guide

1 Introduction to SQL-92 2 Getting Started with SQL-92 3 Basic Table Creation and Data Manipulation 4 Basic Data Definition Language (DDL) 5 Values, Basic Functions, and Expressions 6 Advanced Value Expressions: CASE, CAST, and Row Value Expressions 7 Predicates 8 Working with Multiple Tables: The Relational Operators 9 Advanced SQL Query Expressions 10 Constraints, Assertions, and Referential Integrity 11 Accessing SQL from the Real World 12 Cursors 13 Privileges, Users, and Security 14 Transaction Management 15 Connections and Remote Database Access 16 DYNAMIC SQL 17 Diagnostics and Error Management 18 Internationalization Aspects of SQL-92 19 Information Schema 20 A Look to the Future A Designing SQL-92 Databases B A Complete SQL-92 Example C The SQL-92 Annexes: Differences, Implementation-Defined and Implementation-Dependent Features, Deprecated Features, and Leveling D Relevant Standards Bodies E Status Codes F The SQL Standardization Process G The Complete SQL-92 Language
Patient Perception, Preference and Participation Patients' understanding of prescription instructions in a semi-urban setting in Cameroon

A B S T R A C T Objective: This cross-sectional study investigates the factors associated with patient comprehension of frequently used prescription patterns and explores patients’ preferences for the various methods. Methods: We interviewed two hundred and four consenting patients selected consecutively from the waiting rooms of the St. Elizabeth Catholic Hospital-Shisong in the North West Region of Cameroon. We recorded socio-demographic data and their understanding and preference for four prescription modalities: pictograms, written out, symbols and Latin abbreviations. We studied the relationship between these variables in a logistic multivariate analysis. Results: Understanding was best with symbols (89.7%) and worst when Latin abbreviations (26.9%) were used. Higher levels of education were associated with better understanding of Latin abbreviations (OR 18.87; 95% CI 2.44–142.86), written out prescriptions (OR 58.82; 95% CI 23.25–333.33), symbols (OR 1.47; 95% CI 4.25–50.00) and pictograms (OR 52.63; 92% CI 1.85–142.86) after controlling for confounding. Participants mostly preferred pictograms (40.7%) and written-out prescriptions (30.9%). Conclusion: Latin abbreviations were the most difficult to understand and should no longer be used. Symbols are more easily understood. Practice implications: Latin abbreviations should be discouraged. Symbols are better, especially for patients with low levels of education. Prescribing using pictograms and plain text may facilitate understanding in this setting.
Clinicopathologic characteristics of familial versus sporadic papillary thyroid carcinoma

SUMMARY It is unclear whether familial non-medullary thyroid carcinoma (FNMTC) is more aggressive than sporadic carcinoma, and its prevalence is still under debate. In this study, we investigated the clinicopathologic features of familial papillary thyroid carcinoma (PTC) compared with its sporadic counterpart. We used data from our hospital between 2008 and 2014 to compare the features of 24 familial PTC with 80 sporadic PTC. The prevalence of familial PTC was 1.5%; 25% of familial PTC exhibited a parent-offspring relationship, and 75% exhibited a sibling relationship. There were significant differences in terms of Hashimoto's thyroiditis, nodular goiter, multicentricity, bilaterality, histologic variant, T stage and N stage between the familial and sporadic PTC groups (all p < 0.05). When we compared sporadic PTC with parent-offspring or sibling familial PTC separately, parent-offspring familial PTC was more Hashimoto's thyroiditis and central LNM, while sibling familial PTC was more prevalent in multifocality and bilaterality than sporadic PTC. The recurrence rate was not significantly higher than that of sporadic PTC in familial PTC. The second generation in parent-offspring familial PTC patients exhibited an earlier age at diagnosis, greater multifocality and a higher metastasis rate than the first generation. Based on our results, we conclude that familial PTC is a clinically distinct entity with an aggressive nature. Because of the frequent presence of benign nodules, multifocality, bilaterality and high rate of recurrence, total or near-total thyroidectomy with neck dissection in these patients might be recommended. To date, the optimal clinical treatment is yet to be established, but improved awareness and screening will permit earlier detection, more timely intervention and improved outcomes for patients and their families.
ANXIETY , DEPRESSION IN PATIENTS RECEIVING CHEMOTHERAPY FOR SOLID TUMORS

Objective: To determine the frequency of anxiety and depression in patients undergoing chemotherapy for solid tumors using Hospital Anxiety Depression Scale (HADS). Study Design: Cross sectional descriptive study. Place and Duration of Study: Out-patient department of Armed Forces Institute of Mental Health, Rawalpindi from June 2011 to December 2011. Methodology: Consecutive non probability sampling technique was used to select patients of age (25-70 years), male or female, who had received atleast 03 cycles of chemotherapy for solid tumors. Those with history of prior psychiatric illness, current use of psychotropic medication or psychoactive substance use, and any major bereavement in past one year were excluded from the study. After taking informed consent, relevant sociodemographic data was collected and HADS was administered. HADS-A cut off score of 7 was taken as significant anxiety while a HADS-D cut off score of 7 was taken as significant depression. Results: The total number of participants was 209. The mean age of patients was 42.9 years, with 55.5% males and 44.5% females. Overall 33/209 (15.8%) patients had anxiety while 56/209 (26.8%) were found to have depression. There was a higher frequency of anxiety and depression in younger patients (less than age 40 years), females, patients who were single or divorced, and patients receiving chemotherapy for pancreatic carcinoma. Conclusion: Patients undergoing chemotherapy suffer from considerable levels of anxiety and depression, thus highlighting the need for specialized interventions.
Reducing register ports for higher speed and lower energy

The key issues for register file design in high-performance processors are access time and energy. While previous work has focused on reducing the number of registers, we propose to reduce the number of register ports through two proposals, one for reads and the other for writes. For reads, we propose bypass hint to reduce register port requirements by avoiding unnecessary register file reads for cases where values are bypassed. Current processors are unable to avoid these unnecessary reads due to timing constraints. For writes, we use register file banking. Current banking schemes assign different banks to instructions that are renamed together, which does not necessarily avoid conflicts among instructions that writeback together We use decoupled rename, a technique which separates dependence and physical tagging of register operands. Decoupled rename allows us to perform physical register allocation just before writeback, avoiding bank conflicts. Our results show that combining bypass hint and write banking, our 1-cycle register file with 6 read ports, and two 4-write-ported banks achieves a 9% processor energy-delay savings over a system using a perfectly-pipelined, 2-cycle register file with 16 read ports and 8 write ports.
Gonadal function and parenthood 20 years after treatment for childhood lymphoma: A cross‐sectional study

Gonadal function decades after treatment for childhood lymphoma (CL) is not well described. This cross‐sectional study had two aims: (1) describe long‐term gonadal function and fertility in childhood lymphoma survivors (CLSs), and (2) explore anti‐Mullerian hormone (AMH) as a measure of ovarian function in CLSs.
Experimental and mathematical evaluation of thermal and tensile properties of friction stir welded joint

The aim of this experiment is to develop a mathematical model of friction stir welded joint of aluminium alloy 6061-T6 for correlating the process parameters (rotational speed, welding speed) with output responses (maximum process temperature, yield strength, ultimate tensile strength and % elongation). This developed model will establish an empirical relationship between the modelled values and experimental values. Experiments of AA 6061-T6 FSW butt joints were carried out by using a 'full factorial' design. Analysis of variance and scatter diagram were utilised to assess the significance of the factors and adequacy of the models developed for response variables. The optimum values of output responses, i.e., Tmax, YS, UTS and %E, were found as 417.98°C, 123.92 MPa, 134.42 MPa and 12.07, respectively, at optimum welding parameters (1,000 rpm and 40 mm/min). The influence of FSW process parameters on temperature distribution as well as tensile properties has been analysed in this study.
Hemorrhagic complications of anticoagulant treatment.

Bleeding is the major complication of anticoagulant therapy. The criteria for defining the severity of bleeding varied considerably between studies, accounting in part for the variation in the rates of bleeding reported. Since the last review, there have been several meta-analyses published on the rates of major bleeding in trials of anticoagulants for atrial fibrillation and ischemic heart disease. The major determinants of oral anticoagulant-induced bleeding are the intensity of the anticoagulant effect, underlying patient characteristics, and the length of therapy. There is good evidence that low-intensity oral anticoagulant therapy (targeted INR of 2.5; range, 2.0 to 3.0) is associated with a lower risk of bleeding than therapy targeted at a higher intensity. Lower-intensity regimens (INR 70 years). LMW heparin is not associated with increased major bleeding compared with standard heparin in acute venous thromboembolism. Standard heparin and LMW heparin are not associated with an increase in major bleeding in ischemic coronary syndromes, but are associated with an increase in major bleeding in ischemic stroke.
Human branch point consensus sequence is yUnAy

Yeast carries a strictly conserved branch point sequence (BPS) of UACUAAC, whereas the human BPS is degenerative and is less well characterized. The human consensus BPS has never been extensively explored in vitro to date. Here, we sequenced 367 clones of lariat RT-PCR products arising from 52 introns of 20 human housekeeping genes. Among the 367 clones, a misincorporated nucleotide at the branch point was observed in 181 clones, for which we can precisely pinpoint the branch point. The branch points were comprised of 92.3% A, 3.3% C, 1.7% G and 2.8% U. Our analysis revealed that the human consensus BPS is simply yUnAy, where the underlined is the branch point at position zero and the lowercase pyrimidines (‘y’) are not as well conserved as the uppercase U and A. We found that the branch points are located 21–34 nucleotides upstream of the 3′ end of an intron in 83% clones. We also found that the polypyrimidine tract spans 4–24 nucleotides downstream of the branch point. Our analysis demonstrates that the human BPSs are more degenerative than we have expected and that the human BPSs are likely to be recognized in combination with the polypyrimidine tract and/or the other splicing cis-elements.
THE NATURE OF GROWING BULGES WITHIN z < 1.3 GALAXY DISKS IN THE GOODS-N FIELD

We analyze central surface brightness μ0, nuclear and global colors of intermediate redshift disk galaxies. On an apparent-diameter-limited sample of 398 galaxies from ACS/HST (Advanced Camera for Surveys in the Hubble Space Telescope) The Great Observatories Origins Deep Survey North (GOODS-N), we find 131 galaxies with bulges and 214 without. Up to z ∼ 0.8, blue, star-forming nuclei are found in galaxies with low μ0 only; all high-μ0 nuclei show red, passive colors, so that nuclear and global (U − B) colors strongly correlate with central surface brightness, as found in the local universe. At 0.8 < z < 1.3, a fraction of ∼27% of the high surface brightness nuclei show blue colors, and positive nuclear color gradients. The associated nuclear star formation must lead to bulge growth inside disks. Population modeling suggests that such blue bulges evolve into local pseudobulges rather than classical bulges. We do not find evidence for rejuvenation of classical bulges at the sampled z. High luminosity active galactic nuclei (AGNs) become common at 0.8 < z < 1.3, perhaps pointing to a role of AGNs in the growth or star formation truncation of bulges.