Miracle-dz/UniFAR-FTUs huggingface dataset:
The initial inward current in spherical clusters of chick embryonic heart cells

The rapid inward sodium current in spherical clusters of 11-d-old embryonic chick heart cells, ranging in size between 65 and 90 micron diameter, was studied using the two-microelectrode voltage-clamp technique. Using these preparations, it was possible to resolve the activation phase of the rapid inward current for potentials negative to -25 mV at 37 degrees C. The rapid inward current exhibited a voltage and time dependence similar to that observed in other excitable tissues. It was initiated at potential steps more positive than -45 mV. The magnitude of the current reached its maximum value at a potential of approximately -20 mV. The measured reversal potential was that predicted by the Nernst equation for sodium ions. The falling phase of the current followed a single exponential time-course with a time constant of inactivation, tau h, ranging between 2.14 ms at -40 mV and 0.18 ms at -5 mV. The time constant of inactivation, tau h, determined by a single voltage-step protocol was compared to the constant, tau c, determined by a double voltage-step protocol and no significant different between the two constants of inactivation was found. Furthermore, the time constants of inactivation and reactivation at the same potential in the same preparation were similar. The results of this study demonstrate that the sodium current of heart cells recorded at 37 degrees C can be described by Hodgkin-Huxley kinetics with speeds approximately four times faster than the squid giant axon at 15 degrees C.
AWavetable Synthesis System with 3 D Lip Animation for Real-time Speech and Singing Applications on Mobile Platforms

Singing synthesis is a rising musical art form gaining popularity amongst composers and end-listeners alike. To date, this art form is largely confined to offline boundaries of the music studio, whereas a large part music is about live performances. This calls for a real-time synthesis system readily deployable for onstage applications. SERAPHIM is a wavetable synthesis system that is lightweight and deployable on mobile platforms. Apart from conventional offline studio applications, SERAPHIM also supports real-time synthesis applications, enabling live control inputs for on-stage performances. It also provides for easy lip animation control. SERAPHIM will be made available as a toolbox on Unity 3D for easy adoption into game development across multiple platforms. A readily compiled version will also be deployed as a VST studio plugin, directly addressing end users. It currently supports Japanese (singing only) and Mandarin (speech and singing) languages. This paper describes our work on SERAPHIM and discusses its capabilities and applications.
Identification and Validation of Protein Biomarkers of Response to Neoadjuvant Platinum Chemotherapy in Muscle Invasive Urothelial Carcinoma

Background The 5-year cancer specific survival (CSS) for patients with muscle invasive urothelial carcinoma of the bladder (MIBC) treated with cystectomy alone is approximately 50%. Platinum based neoadjuvant chemotherapy (NAC) plus cystectomy results in a marginal 5-10% increase in 5-year CSS in MIBC. Interestingly, responders to NAC (<ypT2) have a 5-year CSS of 90% which is in stark contrast to the 30-40% CSS for those whose MIBC is resistance to NAC. While the implementation of NAC for MIBC is increasing, it is still not widely utilized due to concerns related to delay of cystectomy, potential side-effects, and inability to predict effectiveness. Recently suggested molecular signatures of chemoresponsiveness, which could prove useful in this setting, would be of considerable utility but are yet to be translated into clinical practice. Methods mRNA expression data from a prior report on a NAC-treated MIBC cohort were re-analyzed in conjunction with the antibody database of the Human Protein Atlas (HPA) to identify candidate protein based biomarkers detectable by immunohistochemistry (IHC). These candidate biomarkers were subsequently tested in tissue microarrays derived from an independent cohort of NAC naive MIBC biopsy specimens from whom the patients were treated with neoadjuvant gemcitabine cisplatin NAC and subsequent cystectomy. The clinical parameters that have been previously associated with NAC response were also examined in our cohort. Results Our analyses of the available mRNA gene expression data in a discovery cohort (n = 33) and the HPA resulted in 8 candidate protein biomarkers. The combination of GDPD3 and SPRED1 resulted in a multivariate classification tree that was significantly associated with NAC response status (Goodman-Kruskal γ = 0.85 p<0.0001) in our independent NAC treated MIBC cohort. This model was independent of the clinical factors of age and clinical tumor stage, which have been previously associated with NAC response by our group. The combination of both these protein biomarkers detected by IHC in biopsy specimens along with the relevant clinical parameters resulted in a prediction model able to significantly stratify the likelihood of NAC resistance in our cohort (n = 37) into two well separated halves: low-26% n = 19 and high-89% n = 18, Fisher’s exact p = 0.0002). Conclusion We illustrate the feasibility of translating a gene expression signature of NAC response from a discovery cohort into immunohistochemical markers readily applicable to MIBC biopsy specimens in our independent cohort. The results from this study are being characterized in additional validation cohorts. Additionally, we anticipate that emerging somatic mutations in MIBC will also be important for NAC response prediction. The relationship of the findings in this study to the current understanding of variant histologic subtypes of MIBC along with the evolving molecular subtypes of MIBC as it relates to NAC response remains to be fully characterized.
Over-Selection: An attempt to boost EDA under small population size

Estimation of distribution algorithm (EDA) is a new class of evolutionary algorithms with a wide range of real-world applications. However, it has been well known that the performance of EDA is not satisfactory enough if its population size is small. But to simply increase its population size may result in slow convergence. To the best knowledge of the authors', very few work has been done on improving the performance of EDA under small population size. This paper illustrates why EDA does not work well under small population size and proposes a novel approach termed as Over-Selection to boost EDA under small population size. Experimental results on several benchmark problems demonstrate that Over-Selection based EDA is often able to achieve a better solution without significantly increasing its time consumption when compared with the original version of EDA.
Vein Graft Closure Of Eardrum Perforations

A central or marginal perforation of the eardrum can be closed by placing a small piece of vein graft beneath the perforation in the middle ear and encouraging the epithelium of the drum to proliferate over it. I discovered this technique while doing a fenestration of the oval window operation in which the drum was accidently torn at the margin while elevating it from its sulcus. A triangular marginal defect resulted with its base on the annulus, about one-tenth the area of the drum. This was in the postero-inferior quadrant of the drum where such perforations are prone to occur during the elevation of the flap. After completing the operation I reapproximated the edges of the defect as completely as possible. I then put a small piece of vein graft just beneath the perforation, the intima toward the middle ear and the adventitia in contact with the undersurface of the
The role of repulsive guidance molecules in the embryonic and adult vertebrate central nervous system

During the development of the nervous system, outgrowing axons often have to travel long distances to reach their target neurons. In this process, outgrowing neurites tipped with motile growth cones rely on guidance cues present in their local environment. These cues are detected by specific receptors expressed on growth cones and neurites and influence the trajectory of the growing fibres. Neurite growth, guidance, target innervation and synapse formation and maturation are the processes that occur predominantly but not exclusively during embryonic or early post-natal development in vertebrates. As a result, a functional neural network is established, which is usually remarkably stable. However, the stability of the neural network in higher vertebrates comes at an expensive price, i.e. the loss of any significant ability to regenerate injured or damaged neuronal connections in their central nervous system (CNS). Most importantly, neurite growth inhibitors prevent any regenerative growth of injured nerve fibres. Some of these inhibitors are associated with CNS myelin, others are found at the lesion site and in the scar tissue. Traumatic injuries in brain and spinal cord of mammals induce upregulation of embryonic inhibitory or repulsive guidance cues and their receptors on the neurites. An example for embryonic repulsive directional cues re-expressed at lesion sites in both the rat and human CNS is provided with repulsive guidance molecules, a new family of directional guidance cues.
Correlating Agricultural Use of Organophosphates with Outdoor Air Concentrations: A Particular Concern for Children

For the organophosphate pesticide chlorpyrifos, median inhalation noncancer, acute children’s exposures in agricultural communities are elevated above reference doses; for diazinon, similar exposures are nearly elevated. We used multivariate linear regression analysis to examine the temporal and spatial associations between agricultural use and measured air concentrations of chlorpyrifos, chlorpyrifos oxon, diazinon, and malathion. Agricultural use within a 3-mile radius on the monitoring day and use on the 2–4 prior days were significantly associated with air concentrations (p < 0.01) for all analytes except malathion; chlorpyrifos oxon showed the strongest association (p < 0.0001). In the final models, which included weather parameters, the proportion of variance (r 2, adjusted for the number of model variables) for all analytes ranged from 0.28 (p < 0.01) for malathion to 0.65 (p < 0.0001) for diazinon. Recent cellular, animal, and human evidence of toxicity, particularly in newborns, supports the public health concern indicated by initial risk estimates. Agricultural applications of organophosphates and their oxon products may have substantial volatization and off-field movement and are a probable source of exposures of public health concern.
Speaker-Sex Discrimination for Voiced and Whispered Vowels at Short Durations

Whispered vowels, produced with no vocal fold vibration, lack the periodic temporal fine structure which in voiced vowels underlies the perceptual attribute of pitch (a salient auditory cue to speaker sex). Voiced vowels possess no temporal fine structure at very short durations (below two glottal cycles). The prediction was that speaker-sex discrimination performance for whispered and voiced vowels would be similar for very short durations but, as stimulus duration increases, voiced vowel performance would improve relative to whispered vowel performance as pitch information becomes available. This pattern of results was shown for women’s but not for men’s voices. A whispered vowel needs to have a duration three times longer than a voiced vowel before listeners can reliably tell whether it’s spoken by a man or woman (∼30 ms vs. ∼10 ms). Listeners were half as sensitive to information about speaker-sex when it is carried by whispered compared with voiced vowels.
Opposing Effects of Neuronal Activity on Structural Plasticity

The connectivity of the brain is continuously adjusted to new environmental influences by several activity-dependent adaptive processes. The most investigated adaptive mechanism is activity-dependent functional or synaptic plasticity regulating the transmission efficacy of existing synapses. Another important but less prominently discussed adaptive process is structural plasticity, which changes the connectivity by the formation and deletion of synapses. In this review, we show, based on experimental evidence, that structural plasticity can be classified similar to synaptic plasticity into two categories: (i) Hebbian structural plasticity, which leads to an increase (decrease) of the number of synapses during phases of high (low) neuronal activity and (ii) homeostatic structural plasticity, which balances these changes by removing and adding synapses. Furthermore, based on experimental and theoretical insights, we argue that each type of structural plasticity fulfills a different function. While Hebbian structural changes enhance memory lifetime, storage capacity, and memory robustness, homeostatic structural plasticity self-organizes the connectivity of the neural network to assure stability. However, the link between functional synaptic and structural plasticity as well as the detailed interactions between Hebbian and homeostatic structural plasticity are more complex. This implies even richer dynamics requiring further experimental and theoretical investigations.
Sensorimotor returning in complex regional pain syndrome parallels pain reduction

Patients with complex regional pain syndrome (CRPS) and intractable pain showed a shrinkage of cortical maps on primary (SI) and secondary somatosensory cortex (SII) contralateral to the affected limb. This was paralleled by an impairment of the two‐point discrimination thresholds. Behavioral treatment over 1 to 6 months consisting of graded sensorimotor retuning led to a persistent decrease in pain intensity, which was accompanied by a restoration of the impaired tactile discrimination and regaining of cortical map size in contralateral SI and SII. This suggests that the reversal of tactile impairment and cortical reorganization in CRPS is associated with a decrease in pain. Ann Neurol 2005;57:425–429
The Computational Complexity of the Restricted Isometry Property, the Nullspace Property, and Related Concepts in Compressed Sensing

This paper deals with the computational complexity of conditions which guarantee that the NP-hard problem of finding the sparsest solution to an underdetermined linear system can be solved by efficient algorithms. In the literature, several such conditions have been introduced. The most well-known ones are the mutual coherence, the restricted isometry property (RIP), and the nullspace property (NSP). While evaluating the mutual coherence of a given matrix is easy, it has been suspected for some time that evaluating RIP and NSP is computationally intractable in general. We confirm these conjectures by showing that for a given matrix A and positive integer k, computing the best constants for which the RIP or NSP hold is, in general, NP-hard. These results are based on the fact that determining the spark of a matrix is NP-hard, which is also established in this paper. Furthermore, we also give several complexity statements about problems related to the above concepts.
Ruptured Corpus Luteal Cyst: Prediction of Clinical Outcomes with CT

Objective To evaluate the determinant pretreatment CT findings that can predict surgical intervention for patients suffering from corpus luteal cyst rupture with hemoperitoneum. Materials and Methods From January 2009 to December 2014, a total of 106 female patients (mean age, 26.1 years; range, 17–44 years) who visited the emergency room of our institute for acute abdominal pain and were subsequently diagnosed with ruptured corpus luteal cyst with hemoperitoneum were included in the retrospective study. The analysis of CT findings included cyst size, cyst shape, sentinel clot sign, ring of fire sign, hemoperitoneum depth, active bleeding in portal phase and attenuation of hemoperitoneum. The comparison of CT findings between the surgery and conservative management groups was performed with the Mann-Whitney U test or chi-square test. Logistic regression analysis was used to determine significant CT findings in predicting surgical intervention for a ruptured cyst. Results Comparative analysis revealed that the presence of active bleeding and the hemoperitoneum depth were significantly different between the surgery and conservative management groups and were confirmed as significant CT findings for predicting surgery, with adjusted odds ratio (ORs) of 3.773 and 1.318, respectively (p < 0.01). On the receiver-operating characteristic curve analysis for hemoperitoneum depth, the optimal cut-off value was 5.8 cm with 73.7% sensitivity and 58.6% specificity (Az = 0.711, p = 0.004). In cases with a hemoperitoneum depth > 5.8 cm and concurrent active bleeding, the OR for surgery increased to 5.786. Conclusion The presence of active bleeding and the hemoperitoneum depth on a pretreatment CT scan can be predictive warning signs of surgery for a patient with a ruptured corpus luteal cyst with hemoperitoneum.
Structure of the tendon connective tissue

Tendons consist of collagen (mostly type I collagen) and elastin embedded in a proteoglycan‐water matrix with collagen accounting for 65–80% and elastin approximately 1–2% of the dry mass of the tendon. These elements are produced by tenoblasts and tenocytes, which are the elongated fibroblasts and fibrocytes that lie between the collagen fibers, and are organized in a complex hierarchical scheme to form the tendon proper. Soluble tropocollagen molecules form cross‐links to create insoluble collagen molecules which then aggregate progressively into microfibrils and then into electronmicroscopically clearly visible units, the collagen fibrils. A bunch of collagen fibrils forms a collagen fiber, which is the basic unit of a tendon. A fine sheath of connective tissue called endotenon invests each collagen fiber and binds fibers together. A bunch of collagen fibers forms a primary fiber bundle, and a group of primary fiber bundles forms a secondary fiber bundle. A group of secondary fiber bundles, in turn, forms a tertiary bundle, and the tertiary bundles make up the tendon. The entire tendon is surrounded by a fine connective tissue sheath called epitenon. The three‐dimensional ultrastructure of tendon fibers and fiber bundles is complex. Within one collagen fiber, the fibrils are oriented not only longitudinally but also transversely and horizontally. The longitudinal fibers do not run only parallel but also cross each other, forming spirals. Some of the individual fibrils and fibril groups form spiral‐type plaits. The basic function of the tendon is to transmit the force created by the muscle to the bone, and, in this way, make joint movement possible. The complex macro‐ and microstructure of tendons and tendon fibers make this possible. During various phases of movements, the tendons are exposed not only to longitudinal but also to transversal and rotational forces. In addition, they must be prepared to withstand direct contusions and pressures. The above‐described three‐dimensional internal structure of the fibers forms a buffer medium against forces of various directions, thus preventing damage and disconnection of the fibers.
Pre-release Prediction of Crowd Opinion on Movies by Label Distribution Learning

This paper studies an interesting problem: is it possible to predict the crowd opinion about a movie before the movie is actually released? The crowd opinion is here expressed by the distribution of ratings given by a sufficient amount of people. Consequently, the pre-release crowd opinion prediction can be regarded as a Label Distribution Learning (LDL) problem. In order to solve this problem, a Label Distribution Support Vector Regressor (LDSVR) is proposed in this paper. The basic idea of LDSVR is to fit a sigmoid function to each component of the label distribution simultaneously by a multi-output support vector machine. Experimental results show that LDSVR can accurately predict peoples's rating distribution about a movie just based on the pre-release metadata of the movie.
Tuning the functional interface of carbon nanotubes by electrochemistry: Toward nanoscale chemical sensors and biosensors

The ability to tune the functional interface of single-walled carbon nanotubes in a versatile manner is key to the success of deploying them as an active material in chemical and biological sensors. Here we present an overview of our device strategies demonstrating the use of controlled electrochemical functionalization to tune this interface by bringing in different functionalities ranging from metallic nanoparticles to biomolecules onto the nanotube surface. The extent of such a functionalization is tunable, providing us with a good control over sensitivity, selectivity, and detection limit of the realized sensors. Moreover, the sensor mechanisms have been analyzed. Taken together the methods and results outlined here constitute a general framework for the rational design of nanoscale field-effect-based chemical sensors and biosensors.
Spray-printed CNT/P3HT organic thermoelectric films and power generators

This study demonstrates the fabrication of high-performance thermoelectric carbon nanotube/poly(3-hexylthiophene) (CNT/P3HT) nanocomposite films and flexible CNT/P3HT organic thermoelectric generators (OTEGs) by spray-printing. The spray-printed few-walled CNT/P3HT nanocomposite films exhibited excellent thermoelectric properties. The Seebeck coefficient, electrical conductivity, and power factor of the nanocomposite films were 97 ± 11 μV K−1, 345 ± 88 S cm−1, and 325 ± 101 μW m−1 K−2, respectively, at room temperature. We fabricated flexible OTEGs solely from p-type CNT/P3HT nanocomposite patterns spray-printed on a polyimide substrate, and confirmed their electric power generation capabilities.
Experiments of FX for NTCIR-9 RITE Japanese BC Subtask

We report results and analyses of our experiments for NTCIR9 RITE Japanese BC subtask we have participated in. It is assumed that the RTE task can be analyzed at some level of accuracy with a simple string-based method using word coverage, although the task seems to require advanced natural language understanding. On the other hand, if you try to tackle the task in the manner to follow your intuition, you should consider at least syntactic features of the texts. However, it is difficult in general to obtain better results for textual inference (TI) with syntactic analysis rather than with word-level analysis. In this paper, we explain our TI method based on syntactic and semantic relations of words in the texts, and conduct experiments.
Analysis of the shielding performance of 2-D periodic screens against near sources

The objective of this paper is to investigate the use of periodic artificial materials for shielding high-frequency high-impedance near fields produced by electric dipoles. The problem is handled numerically by applying the Array Scanning Method that reduces the problem of an aperiodic source close to a periodic screen to a superposition of phased-dipole-array problems (where the array periods are the spatial periods of the shield). As a result, the Floquet theory can be applied and the scattering problem is solved in the unit cell by means of a periodic space-domain Method of Moment, which employs the Ewald transformation to compute the involved Green's functions with accelerated performance. The exact solutions are compared with those derived by a spectral-domain approach with the use of homogeneous models and by the classical transmission-line approximation.