Miracle-dz/UniFAR-FTUs huggingface dataset:
Longitudinal Anti-Müllerian Hormone in Women with Polycystic Ovary Syndrome: An Acupuncture Randomized Clinical Trial

Others have studied acupuncture treatment for polycystic ovary syndrome (PCOS). Anti-müllerian hormone (AMH) is positively correlated with the ovarian follicle pool, thus making it a useful ovarian reserve measure. AMH is elevated in women with PCOS and has been suggested as a diagnostic tool. This study examined the impact of electroacupuncture on AMH concentration in women with PCOS. Seventy-one women with PCOS participated in a randomized, double-blind, sham-controlled clinical trial of acupuncture. Three longitudinal AMH samples over the 5-month protocol were compared with objective ovulation parameters primarily using nonparametric statistics. Results indicated that AMH levels in PCOS were higher than published norms in women without PCOS. There was no difference between the true and sham acupuncture arms in the change in AMH longitudinally. Baseline AMH, but not the change in AMH over time, was inversely correlated with ovulation and menstrual cycle frequencies in both arms combined (P < 0.001). In conclusion, AMH correlated with an increased likelihood of monthly ovulation, as expected from the literature on women without PCOS. The lack of difference by intervention in AMH was consistent with the underlying clinical trial. AMH may be clinically useful to predict which PCOS women are more likely to respond to an intervention.
PROPHYLACTIC PERIPHERAL LASER AND FLUORESCEIN ANGIOGRAPHY AFTER BEVACIZUMAB FOR RETINOPATHY OF PREMATURITY

Purpose: To report reactivation rate after bevacizumab treatment for retinopathy of prematurity (ROP) in eyes with classic ROP (CROP) versus aggressive posterior ROP (APROP) and to report peripheral fluorescein angiography findings in these eyes. Methods: Retrospective chart review was conducted on consecutive infants treated with bevacizumab for ROP, followed by fluorescein angiography and prophylactic laser to persistent avascular retina. Results: Sixty-four eyes of 33 patients were included. Mean gestational age was 25 weeks with mean birth weight of 674 g. Mean follow-up was 125 weeks post-menstrual age (PMA). Reactivation requiring treatment after initial bevacizumab was more common in eyes with APROP (8/16) than with CROP (2/48; P < 0.0001). At mean 73 weeks PMA, eyes with APROP had more avascular retina (mean 4.4 disk diameters vs. 2.6 disk diameters; P = 0.0004) and higher percentage of leakage (11/11 eyes vs. 22/38 eyes; P = 0.01) on fluorescein angiography than in eyes with CROP. Unfavorable outcome occurred in 1 of 16 eyes with APROP and in no eyes with CROP. No eye that underwent prophylactic laser after bevacizumab had a poor structural outcome. Conclusion: In our study, bevacizumab-treated eyes with APROP have a higher likelihood of recurrence and larger area of persistent nonperfusion than in eyes with CROP. Treatment of ROP with bevacizumab followed by prophylactic laser has a low rate of unfavorable structural outcome.
Physical-Layer Authentication Based on Extreme Learning Machine

Most physical-layer authentication techniques use hypothesis tests to compare the radio channel information with the channel record of Alice to detect spoofer Eve in wireless networks. However, the test threshold in the hypothesis test is not always available, especially in dynamic networks. In this letter, we propose a physical-layer authentication scheme based on extreme learning machine that exploit multi-dimensional characters of radio channels and use the training data generated from the spoofing model to improve the spoofing detection accuracy. Simulation results show that our proposed technique can significantly improve the authentication accuracy compared with the state-of-the-art method.
Stabilität des Formgedächtniseffektes in FeNiCoTi-Legierungen

The functionality of FeNiCoTi-shape memory alloys depends on the loading conditions, the microstructure and the quality of the surface. An alternative to the expensive NiTi-materials is offered by using the one- way effect of FeNiCoTi-alloys at stresses from 300 to 400 MPo. The application of iron-base-alloys for actuators with a cyclic loading is restricted to cycle numbers below 100 and will possibly get only a small practical meaning.
Industrial Robustness: Understanding the Mechanism of Tolerance for the Populus Hydrolysate-Tolerant Mutant Strain of Clostridium thermocellum

Background An industrially robust microorganism that can efficiently degrade and convert lignocellulosic biomass into ethanol and next-generation fuels is required to economically produce future sustainable liquid transportation fuels. The anaerobic, thermophilic, cellulolytic bacterium Clostridium thermocellum is a candidate microorganism for such conversions but it, like many bacteria, is sensitive to potential toxic inhibitors developed in the liquid hydrolysate produced during biomass processing. Microbial processes leading to tolerance of these inhibitory compounds found in the pretreated biomass hydrolysate are likely complex and involve multiple genes. Methodology/Principal Findings In this study, we developed a 17.5% v/v Populus hydrolysate tolerant mutant strain of C. thermocellum by directed evolution. The genome of the wild type strain, six intermediate population samples and seven single colony isolates were sequenced to elucidate the mechanism of tolerance. Analysis of the 224 putative mutations revealed 73 high confidence mutations. A longitudinal analysis of the intermediate population samples, a pan-genomic analysis of the isolates, and a hotspot analysis revealed 24 core genes common to all seven isolates and 8 hotspots. Genetic mutations were matched with the observed phenotype through comparison of RNA expression levels during fermentation by the wild type strain and mutant isolate 6 in various concentrations of Populus hydrolysate (0%, 10%, and 17.5% v/v). Conclusion/Significance The findings suggest that there are multiple mutations responsible for the Populus hydrolysate tolerant phenotype resulting in several simultaneous mechanisms of action, including increases in cellular repair, and altered energy metabolism. To date, this study provides the most comprehensive elucidation of the mechanism of tolerance to a pretreated biomass hydrolysate by C. thermocellum. These findings make important contributions to the development of industrially robust strains of consolidated bioprocessing microorganisms.
NOMA assisted joint broadcast and multicast transmission in 5G networks

In this paper, we employ the non-orthogonal multiple access (NOMA) technique to convey joint broadcast and multicast streams to a set of users. Thanks to the spatial beamforming, different groups of users is able to receive different streams in addition to the common broadcast information. With the proposed scheme, the same time-frequency resources can be shared between different streams, without requiring additional bandwidth. The transmitter implementation is presented and two receiver classes are considered based on Successive Interference Cancellation (SIC) and Joint Decoding (JD) approaches. In addition to the performance assessment via simulation, a real hardware proof of concept implementation of the proposed technique is performed in order to show the practical viability of the proposed scheme.
JavaScript: The (Un)Covered Parts

Testing JavaScript code is important. JavaScript has grown to be among the most popular programming languages and it is extensively used to create web applications both on the client and server. We present the first empirical study of JavaScript tests to characterize their prevalence, quality metrics (e.g. code coverage), and shortcomings. We perform our study across a representative corpus of 373 JavaScript projects, with over 5.4 million lines of JavaScript code. Our results show that 22% of the studied subjects do not have test code. About 40% of projects with JavaScript at client-side do not have a test, while this is only about 3% for the purely server-side JavaScript projects. Also tests for server-side code have high quality (in terms of code coverage, test code ratio, test commit ratio, and average number of assertions per test), while tests for client-side code have moderate to low quality. In general, tests written in Mocha, Tape, Tap, and Nodeunit frameworks have high quality and those written without using any framework have low quality. We scrutinize the (un)covered parts of the code under test to find out root causes for the uncovered code. Our results show that JavaScript tests lack proper coverage for event-dependent callbacks (36%), asynchronous callbacks (53%), and DOM-related code (63%). We believe that it is worthwhile for the developer and research community to focus on testing techniques and tools to achieve better coverage for difficult to cover JavaScript code.
The Elements of Botany

IN this little book the elements of botany are presented in a more refreshing form than is too often the case. The author has chosen to emphasise certain principles and phenomena of morphological or of physiological importance, rather than to crowd his pages with vast numbers of facts. Various plants are requisitioned to serve as illustrations of the different subjects under treatment; and thus the student will certainly acquire a clearer and more general conception of what, for instance, a flowering plant is, and how it lives, than would have been possible had only one example been selected as a type, even though this had been far more exhaustively dealt with.The Elements of Botany.By Francis Darwin, Fellow of Christ's College, Cambridge, and Reader of Botany in the University. (Cambridge: University Press, 1895.)
Histone chaperone HIRA regulates neural progenitor cell proliferation and neurogenesis via β-catenin

Histone cell cycle regulator (HIRA) is a histone chaperone and has been identified as an epigenetic regulator. Subsequent studies have provided evidence that HIRA plays key roles in embryonic development, but its function during early neurogenesis remains unknown. Here, we demonstrate that HIRA is enriched in neural progenitor cells, and HIRA knockdown reduces neural progenitor cell proliferation, increases terminal mitosis and cell cycle exit, and ultimately results in premature neuronal differentiation. Additionally, we demonstrate that HIRA enhances &bgr;-catenin expression by recruiting H3K4 trimethyltransferase Setd1A, which increases H3K4me3 levels and heightens the promoter activity of &bgr;-catenin. Significantly, overexpression of HIRA, HIRA N-terminal domain, or &bgr;-catenin can override neurogenesis abnormities caused by HIRA defects. Collectively, these data implicate that HIRA, cooperating with Setd1A, modulates &bgr;-catenin expression and then regulates neurogenesis. This finding represents a novel epigenetic mechanism underlying the histone code and has profound and lasting implications for diseases and neurobiology.
A Framework for End-to-End Service Differentiation: Network Planes and Parallel Internets

This article presents a technology-agnostic and a multi-dimensional (i.e., routing, forwarding, and traffic management dimensions) approach for the management of IP network resources to ensure service differentiation with both intra- and inter-domain scope. This article introduces the network plane (NP) and parallel Internets (PI) concepts for achieving service differentiation. Based on these concepts, a functional architecture together with a business model is presented. In addition, this article describes how the proposed approach can become a promising platform for the IP multimedia subsystem (IMS), with the objective of providing end-to-end QoS-enabled multimedia delivery across multiple providers to replace the flow-based reservation mode known as the VoIP resource reservation framework.
Fiber laser welding of nickel-based superalloy Inconel 718

Inconel 718 (IN 718) is widely used in applications, such as aircraft and power turbine components. Recently, fiber laser welding has become an attractive joining technique in industry for fabrication and repair of service-damaged components. However, a major limitation in the laser welding of IN 718 is that liquation cracking occurs. In the present work, autogenous fiber laser welding of IN 718 was used to study the effects of welding parameters and different pre-weld heat treatments on liquation cracking. Contrary to previous studies, a dual effect of heat input on cracking is observed. A rarely reported effect of heat input is attributed to process instability. Liquation cracking increases with pre-weld heat treatment temperatures that increase grain size and/or, possibly, intregranular boron segregation. The study shows that pre-weld heat treatment at 950oC can be used for repair welding of IN 718 without significant loss in cracking resistance.
Artificial Skin in Robotics

Artificial Skin - A comprehensive interface for system-environment interaction - This thesis investigates a multifunctional artificial skin as touch sensitive whole-body cover for robotic systems. To further the evolution from tactile sensors to an implementable artificial skin a general concept for the design process is derived. A standard test procedure is proposed to evaluate the performance. The artificial skin contributes to a safe and intuitive physical human robot interaction.
Counting Is Easier while Experiencing a Congruent Motion

Several studies suggest that numerical and spatial representations are intrinsically linked. Recent findings demonstrate that also motor actions interact with number magnitude processing, showing a motor-to-semantic effect. The current study assesses whether calculation processes can be modulated by motions performed with the whole body. Participants were required to make additions or subtractions while performing (on-line condition) or after having experienced (off-line condition) an ascending or descending motion through a passive (i.e., taking the elevator) or an active (i.e., taking the stairs) mode. Results show a congruency effect between the type of calculation and the direction of the motion depending on: a) the off-line or on-line condition, b) the passive or active mode and c) the real or imagined task. Implications of the results for an embodied and grounded perspective view will be discussed.
Complex Epigenetic Regulation of Chemotherapy Resistance and Biology in Esophageal Squamous Cell Carcinoma via MicroRNAs

Background: Resistance towards chemotherapy is a major obstacle in the treatment of esophageal squamous cell carcinoma (ESCC). We investigated the role of specific microRNAs in chemotherapy resistance and tumor biology. Methods: We selected three microRNAs from characteristic microRNA signatures of resistant ESCC (hsa-miR-125a-5p, hsa-miR-130a-3p, hsa-miR-1226-3p), and hsa-miR-148a-3p. Effects on chemotherapy, adhesion, migration, apoptosis and cell cycle were assessed in six ESCC cell lines. Target analyses were performed using Western blotting and luciferase techniques. Results: MiR-130a-3p sensitized cells towards cisplatin in 100% of cell lines, miR-148a-3p in 83%, miR-125a-5p in 67%, miR-1226-3p in 50% (p ≤ 0.04). MiR-130a-3p sensitized 83% of cell lines towards 5-FU, miR-148a-3p/miR-125a-5p/miR-1226-3p only 33% (p ≤ 0.015). Several resistance-relevant pathways seem to be targeted on various levels. Bcl-2 was confirmed as a direct target of miR-130a-3p and miR-148a-3p, and p53 as a target of miR-125a-5p. All microRNAs decreased migration and adhesion, except miR-130a-3p, and increased apoptosis. Simultaneous manipulation of two microRNAs exhibited additive sensitizing effects towards cisplatin in 50% (miR-125a-5p/miR-148a-3p), and 75% (miR-148a-3p/miR-130a-3p) of cell lines (p ≤ 0.006). Conclusion: Our data present strong evidence that specific microRNA signatures are responsible for drug resistance and aggressiveness of ESCC. Final functional readout of these complex processes appears to be more important than single microRNA-target interactions.
Integrating a Parent-Implemented Blend of Developmental and Behavioral Intervention Strategies into Speech-Language Treatment for Toddlers at Risk for Autism Spectrum Disorder

Abstract Naturalistic developmental behavioral interventions include an explicit focus on coaching parents to use therapy techniques in daily routines and are considered best practice for young children with autism. Unfortunately, these approaches are not widely used in community settings, possibly due to the clinical expertise and training required. This article presents the work of the Bond, Regulate, Interact, Develop, Guide, Engage (BRIDGE Collaborative), a multidisciplinary group of service providers (including speech-language pathologists), parents, funding agency representatives, and researchers dedicated to improving the lives of young children with autism spectrum disorder and their families. The group selected and adapted a parent coaching naturalistic developmental behavioral intervention specifically for use with toddlers and their families for community implementation. Lessons learned from the implementation process include the importance of therapist background knowledge, the complexity of working with parents of young children, and needed supports for those working closely with parents, including specific engagement strategies and the incorporation of reflective practice.
Evaluation of an Electronic Module for Reconciling Medications in Home Health Plans of Care

Summary Objectives Transitions in patient care pose an increased risk to patient safety. One way to reduce this risk is to ensure accurate medication reconciliation during the transition. Here we present an evaluation of an electronic medication reconciliation module we developed to reduce the transition risk in patients referred for home healthcare. Methods Nineteen physicians with experience in managing home health referrals were recruited to participate in this within-subjects experiment. Participants completed medication reconciliation for three clinical cases in each of two conditions. The first condition (paper-based) simulated current practice – reconciling medication discrepancies between a paper plan of care (CMS 485) and a simulated Electronic Health Record (EHR). For the second condition (electronic) participants used our medication reconciliation module, which we integrated into the simulated EHR. To evaluate the effectiveness of our medication reconciliation module, we employed repeated measures ANOVA to test the hypotheses that the module will: 1) Improve accuracy by reducing the number of unaddressed medication discrepancies, 2) Improve efficiency by reducing the reconciliation time, 3) have good perceived usability. Results The improved accuracy hypothesis is supported. Participants left more discrepancies unaddressed in the paper-based condition than the electronic condition, F (1,1) = 22.3, p < 0.0001 (Paper Mean = 1.55, SD = 1.20; Electronic Mean = 0.45, SD = 0.65). However, contrary to our efficiency hypothesis, participants took the same amount of time to complete cases in the two conditions, F (1, 1) =0.007, p = 0.93 (Paper Mean = 258.7 seconds, SD = 124.4; Electronic Mean = 260.4 seconds, SD = 158.9). The usability hypothesis is supported by a composite mean ability and confidence score of 6.41 on a 7-point scale, 17 of 19 participants preferring the electronic system and an SUS rating of 86.5. Conclusion We present the evaluation of an electronic medication reconciliation module that increases detection and resolution of medication discrepancies compared to a paper-based process. Further work to integrate medication reconciliation within an electronic medical record is warranted.
The Production of Ground Truths for Evaluating Highly Accurate Stereovision Algorithms

The conception and improvement of algorithms for subpixel stereovision requires very precise test databases. The state of the art on the sets of images used extensively by the scientiﬁc community shows that they are often incomplete and imprecise compared to the dataset goals. We will present a method based on image synthesis to produce stereoscopic pairs with ground truths such as disparity and occlusion maps reaching an accuracy of about 10 − 6 pixels. The a priori noise estimate is also taken into account. This process allows us to deliver a new image database consisting of 66 stereo pairs together with their ground truths.
Synthesis of fine and high purity Cr2AlC powders by novel method

Cr2AlC powders using Cr/Al/C and Cr/Al/Cr3C2 systems as raw materials were successfully synthesised by a microwave hybrid heating method for the first time. The mixtures of Cr, Al and graphite or Cr3C2 with different molar ratios were used to investigate the formation of Cr2AlC phase. For Cr/Al/C with the molar ratios of 2:(1.0–1.2):1 system, Cr2AlC with a small amount of Cr7C3 and Cr2Al was synthesised at 1000°C for 3 min, and the average particle size was ˜1 μm. For Cr/Al/Cr3C2 with the molar ratio of 1:2:1 system, high purity Cr2AlC powders was synthesised at 1000°C for 3 min, and the average particle size was ˜1 μm. The synthesis of high purity Cr2AlC powders for short time was attributed to the combination of the hybrid heating effect and the introduction of Cr3C2 as carbon source. Microwave hybrid heating is a promising method for the preparation of various other MAX phases.
Tyrant Dinosaur Evolution Tracks the Rise and Fall of Late Cretaceous Oceans

The Late Cretaceous (∼95–66 million years ago) western North American landmass of Laramidia displayed heightened non-marine vertebrate diversity and intracontinental regionalism relative to other latest Cretaceous Laurasian ecosystems. Processes generating these patterns during this interval remain poorly understood despite their presumed role in the diversification of many clades. Tyrannosauridae, a clade of large-bodied theropod dinosaurs restricted to the Late Cretaceous of Laramidia and Asia, represents an ideal group for investigating Laramidian patterns of evolution. We use new tyrannosaurid discoveries from Utah—including a new taxon which represents the geologically oldest member of the clade—to investigate the evolution and biogeography of Tyrannosauridae. These data suggest a Laramidian origin for Tyrannosauridae, and implicate sea-level related controls in the isolation, diversification, and dispersal of this and many other Late Cretaceous vertebrate clades.