Miracle-dz/UniFAR-FTUs huggingface dataset:
Ets-1 Is a Critical Transcriptional Regulator of Reactive Oxygen Species and p47phox Gene Expression in Response to Angiotensin II

Angiotensin (Ang) II is a potent mediator of vascular inflammation. A central mechanism by which Ang II promotes inflammation is through the generation of reactive oxygen species (ROS). In the current study, we investigated the role of the transcription factor Ets-1 in regulating Ang II–induced ROS generation. ROS generation was measured in the thoracic aorta of Ets-1−/− mice compared with littermate controls after continuous infusion of Ang II. H2O2 and superoxide anion (O2−) production were significantly blunted in the Ets-1−/− mice. Inhibition of Ets-1 expression by small interfering RNA in primary human aortic smooth muscle cells also potently inhibited ROS production and the induction of the NAD(P)H oxidase subunit p47phox in response to Ang II. To evaluate the therapeutic potential of inhibiting Ets-1 in wild-type mice, dominant negative Ets-1 membrane-permeable peptides were administered systemically. Ang II–induced ROS production and medial hypertrophy in the thoracic aorta were markedly diminished as a result of blocking Ets-1. In summary, Ets-1 functions as a critical downstream transcriptional mediator of Ang II ROS generation by regulating the expression of NAD(P)H oxidase subunits such as p47phox.
An Adaptive Multiuser MIMO Receive Algorithm with Radial Space-Division Multiple Access in OFDM System

This paper presents a low-complexity multiuser MIMO detection algorithm. The MIMO receiver exploits Radial space-Division Multiple Access (RDMA) principle, by paring and scheduling the MIMO multiusers with distinguishable radial space-divisions to the receiver. By exploiting the Channel State Information (CSI) and eigenvalue analysis, the MIMO receiver can selectively deploy the Linear Minimum Mean Square Error (L-MMSE) detection or Successive Interference Cancelation (SIC) for the MIMO multiusers. This reduces the complexity for the multiuser detection, by possibly maintaining the performance. The investigation is provided for the Orthogonal Frequency Division Multiplex (OFDM) system. Throughout this paper, an IEEE 802.16e, Worldwide Interoperability Microwave Access (WiMAX), link level simulator is exploited for the uplink performance evaluation.
Lesion symptom mapping of manipulable object naming in nonfluent aphasia: Can a brain be both embodied and disembodied?

Embodied cognition offers an approach to word meaning firmly grounded in action and perception. A strong prediction of embodied cognition is that sensorimotor simulation is a necessary component of lexical–semantic representation. One semantic distinction where motor imagery is likely to play a key role involves the representation of manufactured artefacts. Many questions remain with respect to the scope of embodied cognition. One dominant unresolved issue is the extent to which motor enactment is necessary for representing and generating words with high motor salience. We investigated lesion correlates of manipulable relative to nonmanipulable name generation (e.g., name a school supply; name a mountain range) in patients with nonfluent aphasia (N = 14). Lesion volumes within motor (BA4, where BA = Brodmann area) and premotor (BA6) cortices were not predictive of category discrepancies. Lesion symptom mapping linked impairment for manipulable objects to polymodal convergence zones and to projections of the left, primary visual cortex specialized for motion perception (MT/V5+). Lesions to motor and premotor cortex were not predictive of manipulability impairment. This lesion correlation is incompatible with an embodied perspective premised on necessity of motor cortex for the enactment and subsequent production of motor-related words. These findings instead support a graded or “soft” approach to embodied cognition premised on an ancillary role of modality-specific cortical regions in enriching modality-neutral representations. We discuss a dynamic, hybrid approach to the neurobiology of semantic memory integrating both embodied and disembodied components.
The Role of Feedback on the Relationship Between Budgetary Participation and Performance

This study examines the moderating effect of feedback on the relationship between budgetary participation and performance. The responses of 79 managers, drawn from a cross‐section of Australian manufacturing companies, to a questionnaire survey were analysed using a multiple regression technique. The results show that independently, budgetary participation and feedback have no effect on performance. The results confirm that the higher the level of feedback, the more positive is the relationship between budgetary participation and performance.
The Auditing of Public Policy and the Politics of Auditing: The U.S. GAO and Israel's State Comptroller

A purist conception of audit independence appears to be obsolete. A survey of audit activities of the U.S. General Accounting Office (GAO) and Israel's State Comptroller describes pressures on audit bodies to examine sensitive policy issues and to enter partisan and personal squabbles between elected officials. The critique of the GAO by the National Academy of Public Administration recommends that legislators refrain from asking the audit body to deal with politically sensitive issues. In order to salvage something from the principle of audit independence, it appears more realistic to urge diligence on the part of the supreme auditor.
Modulation of Fas-Dependent Apoptosis: A Dynamic Process Controlling Both the Persistence and Death of CD4 Regulatory T Cells and Effector T Cells1

We have previously shown that regulatory CD25+CD4+ T cells are resistant to clonal deletion induced by viral superantigen in vivo. In this work we report that isolated CD25+CD4+ T cells activated in vitro by anti-CD3 Ab are resistant to Fas-induced apoptosis, in contrast to their CD25−CD4+ counterparts. Resistance of CD25+CD4+ T cells to Fas-dependent activation-induced cell death is not linked to their inability to produce IL-2 or to their ability to produce IL-10. The sensitivity of both populations to Fas-induced apoptosis can be modulated in vitro by changing the CD25+CD4+:CD25−CD4+ T cell ratio. The sensitivity of CD25−CD4+ T cells to apoptosis can be reduced, while the sensitivity of CD25+CD4+ T cells can be enhanced. Modulation of Fas-dependent apoptosis is associated with changes in cytokine production. However, while CD25−CD4+ T cell apoptosis is highly dependent on IL-2 (production of which is inhibited by CD25+CD4+ T cells in coculture), modulation of CD25+CD4+ T cell apoptosis is IL-2 independent. Taken together, these results suggest that CD25+CD4+ and CD25−CD4+ T cell sensitivity to Fas-dependent apoptosis is dynamically modulated during immune responses; this modulation appears to help maintain a permanent population of regulatory T cells required to control effector T cells.
E-Government as an Instrument of Fiscal Accountability and Responsiveness

Fiscal transparency and citizen participation in budgeting processes are widely promoted as means toward the ends of democratic accountability and responsiveness in the allocation and use of public funds. In the past decade, academics and practitioners enthusiastic about e-government have emphasized the potential for using information technology to enhance democratic governance. Putting these two streams of public administration theory and practice together, the authors developed criteria for assessing e-budgeting efforts and applied them to a sample of Web sites operated by state and local governments. Although practitioners are ahead of academics in exploring the potential of e-government for improving fiscal accountability and responsiveness, practice lags behind the relevant basic recommendations of the Government Finance Officers Association. This finding leads to research and practice agendas aimed at enhancing the use of e-government to enhance fiscal transparency and participation.
Participation in the EU Eco-management and audit scheme: an analysis of small -and medium- sized enterprises in Italy

The EU Eco-Management and Audit Scheme (EMAS) reflects the increasing emphasis that is being given to voluntary environmental regulation. Although this approach is generally welcomed as a complement to command and control regulation, concerns remain about the level of voluntary participation. The findings are presented of a pilot study in Italy which sought to examine the prospects for EMAS in small- and medium-sized enterprises in the chemical industry.
War, markets, and the reconfiguration of West Africa's weak states

In a recent book, I. William Zartman declares that Africa's "collapsed states" suffer "a long-term degenerative disease" and offers that "cure and remission are possible. "' This and other analyses of conflict and declining bureaucratic capacity in African countries take the prevailing system of sovereign states as inevitable. Related "govemance" approaches to African political economies often prescribe social and territorial boundaries of sovereign states. That is, they focus on the development of linkages between states and societies to increase taxing capabilities, identify a distinct public interest, and build competent bureaucracies accountable to popular needs.2 Alternatively, readers are warned that "societal disengagement would, if carried out to its logical conclusion, result in the dissolution of the political community, as it has done in contemporary Somalia and Liberia. "3 But this conclusion is not true.
Outcome of conditioning intensity in acute myeloid leukemia with monosomal karyotype in patients over 45 year‐old: A study from the acute leukemia working party (ALWP) of the European group of blood and marrow transplantation (EBMT)

Acute myeloid leukemia with monosomal karyotype (MK AML) carries a very poor prognosis, even after allogeneic stem cell transplantation (SCT). However, SCT remains the only curative option in this high‐risk population. Because myeloablative conditioning regimen (MAC) is associated with less relapse, we hypothesized that more intensive conditioning regimen might be beneficial for MK AML patients. We reviewed 303 patients over age 45 diagnosed with either de novo or secondary MK AML. One hundred and five patients received a MAC and 198 a reduced‐intensity conditioning (RIC). The median age at SCT was 57‐year‐old, significantly lower in the MAC (53‐year‐old) than in the RIC group (59‐year‐old). The median follow‐up was 42 months (range, 3 − 156 months). The 3‐year overall survival (OS), leukemia‐free survival (LFS), and relapse rate (RR) were not significantly different between both groups with overall values of 34%, 29%, and 51%, respectively. On the contrary, the 3‐year nonrelapse mortality (NRM) was significantly higher in MAC recipients (28%) compared with RIC patients (16%, P = 0.004). The incidence of Grades II to IV acute graft‐versus‐host disease (GvHD) was significantly higher after a MAC (30.5%) than after a RIC (19.3%, P = 0.02). That of chronic GvHD was comparable between both groups (35%) and did not impact on LFS. Interestingly, within our MK AML cohort, hypodiploidy was significantly associated with worse outcomes. Due to reduced toxicity and comparable OS, LFS, and RR, RIC appears as a good transplant option in the very high‐risk population, including older patients, diagnosed with MK AML. Am. J. Hematol. 90:719–724, 2015. © 2015 Wiley Periodicals, Inc.
Prevalence and impact of musculoskeletal disorders of the upper limb in the general population.

OBJECTIVE To determine the prevalence, interrelation, and impact of musculoskeletal disorders of the upper limb in the general population. METHODS A total of 9,696 randomly selected adults of working age were surveyed in a 2-stage cross-sectional study involving a screening questionnaire and a standardized physical examination in symptomatic subjects. Age- and sex-specific prevalence rates were estimated for several musculoskeletal disorders and for nonspecific pain in the upper limbs. The overlap and impact on daily activities and healthcare utilization were explored. RESULTS Among 6,038 first-stage responders, 3,152 reported upper limb symptoms and 1,960 were subsequently examined. Of subjects with pain, 44.8% had 1 or more specific soft-tissue disorders. Site-specific prevalence rates were as follows: shoulder tendinitis 4.5% among men and 6.1% among women; adhesive capsulitis 8.2% among men and 10.1% among women; lateral epicondylitis 1.3% among men and 1.1% among women; de Quervain's disease 0.5% among men and 1.3% among women; other tenosynovitis of the hand or wrist, 1.1% among men and 2.2% among women. Specific disorders tended to cluster (P < 0.001) in individuals, with particular overlap at the shoulder. Compared with subjects with nonspecific pain, those with specific disorders more often reported inability to perform everyday tasks (P < 0.05), consultation with a doctor (P < 0.05), and use of prescribed medication (P < 0.05). CONCLUSION Upper limb pain is common in the general population and is often associated with physical signs suggestive of specific upper-limb disorders. These disorders have a substantial impact on physical function and use of health care.
A method for reducing the time required to match protein sequences with tandem mass spectra.

An algorithm for reducing the time necessary to match a large set of peptide tandem mass spectra with a list of protein sequences is described. This algorithm breaks the process into multiple steps. A rapid survey step identifies all protein sequences that are reasonable candidates for a match with a set of tandem mass spectra. These candidates are then used as models, which are refined by detailed analysis of the set of tandem mass spectra for evidence of incomplete enzymatic hydrolysis, non-specific hydrolysis and chemical modifications of amino acid residues resulting from either post-translational modifications or sample handling. Compared with current one-step methods for matching proteins to mass spectra, this multiple-step method can decrease the time required for the calculation by several orders of magnitude.
Coxiella burnetii Isolates Cause Genogroup-Specific Virulence in Mouse and Guinea Pig Models of Acute Q Fever

ABSTRACT Q fever is a zoonotic disease of worldwide significance caused by the obligate intracellular bacterium Coxiella burnetii. Humans with Q fever may experience an acute flu-like illness and pneumonia and/or chronic hepatitis or endocarditis. Various markers demonstrate significant phylogenetic separation between and clustering among isolates from acute and chronic human disease. The clinical and pathological responses to infection with phase I C. burnetii isolates from the following four genomic groups were evaluated in immunocompetent and immunocompromised mice and in guinea pig infection models: group I (Nine Mile, African, and Ohio), group IV (Priscilla and P), group V (G and S), and group VI (Dugway). Isolates from all of the groups produced disease in the SCID mouse model, and genogroup-consistent trends were noted in cytokine production in response to infection in the immunocompetent-mouse model. Guinea pigs developed severe acute disease when aerosol challenged with group I isolates, mild to moderate acute disease in response to group V isolates, and no acute disease when infected with group IV and VI isolates. C. burnetii isolates have a range of disease potentials; isolates within the same genomic group cause similar pathological responses, and there is a clear distinction in strain virulence between these genomic groups.
Default Predictors in Retail Credit Scoring: Evidence from Czech Banking Data

Credit to the private sector has risen rapidly in European emerging markets, but its risk evaluation has been largely neglected. Using retail-loan banking data from the Czech Republic, we construct two credit risk models based on logistic regression and classification and regression trees. Both methods are comparably efficient and detect similar financial and socioeconomic variables as the key determinants of default behavior. We also construct a model without the most important financial variable (amount of resources), which performs very well. This way, we confirm significance of sociodemographic variables and link our results with specific issues characteristic to new EU members.
Earth observation-supported service platform for the development and provision of thematic information on the built environment — the TEP-Urban project

The Sentinel fleet will provide a so-far unique coverage with Earth observation (EO) data and therewith new opportunities for the implementation of methodologies to generate innovative geo-information products and services. It is here where the TEP Urban project is supposed to initiate a step change by providing an open and participatory platform based on modern Information and Communication Technologies (ICTs) that enable any interested user to easily exploit EO data pools, in particular those of the Sentinel missions, and derive thematic information on the status and development of the built environment from these data. Key component of TEP Urban project is the implementation of a web-based platform employing distributed high-level computing infrastructures and providing key functionalities for i) high-performance access to satellite imagery and derived thematic data, ii) modular and generic state-of-the-art pre-processing, analysis, and visualization techniques, iii) customized development and dissemination of algorithms, products and services, and iv) networking and communication. This contribution introduces the main facts about the TEP Urban project, including a description of the general objectives, the platform systems design and functionalities, and the preliminary portfolio products and services available at the TEP Urban platform.
Wildfires in northern Siberian larch dominated communities

The fire history of the northern larch forests within the permafrost zone in a portion of northern Siberia (∼66°N, 100°E) was studied. Since there is little to no human activity in this area, fires within the study area were mostly caused by lightning. Fire return intervals (FRI) were estimated on the basis of burn marks on tree stems and dates of tree natality. FRI values varied from 130 to 350 yr with a 200 ± 50 yr mean. For southerly larch dominated communities, FRI was found to be shorter (77 ± 20 yr at ∼ 61°N, and 82 ± 7 at 64°N), and it was longer at the northern boundary (∼71°) of larch stands (320 ± 50 yr). During the Little Ice Age period in the 16th–18th centuries, FRI was approximately twice as long those as recorded in this study. Fire caused changes in the soil including increases in soil drainage and permafrost thawing depth, and a radial growth increase to about twice the background value (with more than six times observed in extreme cases). This effect may simulate the predicted warming impact on the larch growth in the permafrost zone.
Leading Indicators for the Service Sector

Since the service sector currently accounts for a large and growing share of U.S. economic activity, we have undertaken to develop indicators that throw light on its current status and future prospects. A composite coincident index of aggregate economic activity in the service sector is constructed, and a growth-cycle chronology is identified based on growth rates in this index and in its components. Then several macroeconomic leading indicators of service are identified, and from them a composite leading index is constructed. The growth rate in this index is found to give advance warnings of major swings in the growth of the service sector.
Disruption of the Kluyveromyces lactis GGS1 gene causes inability to grow on glucose and fructose and is suppressed by mutations that reduce sugar uptake.

In the yeast Saccharomyces cerevisiae the GGS1 gene is essential for growth on glucose or other readily fermentable sugars. GGS1 is the same gene as TPS1 which was identified as encoding a subunit of the trehalose-6-phosphate synthase/phosphatase complex and it is allelic to the fdp1, byp1, glc6 and cif1 mutations. Its precise function in the regulation of sugar catabolism is unknown. We have cloned the GGS1 homologue from the distantly related yeast Kluyveromyces lactis. The KlGGS1 gene is 74% and 79% identical at the nucleotide and amino acid sequence level, respectively, to the S. cerevisiae counterpart. We also compared the sequence with the partly homologous products of the S. cerevisiae genes TPS2 and TSL1 which code for the larger subunits of the trehalose synthase complex and with a TSL1 homologue, TPS3, of unknown function. Multiple alignment of these sequences revealed several particularly well conserved elements. Disruption of GGS1 in K. lactis caused the same pleiotropic phenotype as in S. cerevisiae, i.e. inability to grow on glucose or fructose and strongly reduced trehalose content. We have also studied short-term glucose-induced regulatory effects related to cAMP and cAMP-dependent protein kinase, i.e. the cAMP signal, trehalase activation, trehalose mobilization and inactivation of fructose-1,6-bisphosphatase. These effects occur very rapidly in S. cerevisiae and are absent in the Scggs1 mutant. In K. lactis all these effects were much slower and largely unaffected by the Klggs1 mutation. On the other hand, glucose strongly induced pyruvate decarboxylase and activated the potassium transport system in K. lactis and both effects were absent in the Klggs1 mutant. Addition of glucose to galactose-grown cells of the Klggs1 mutant caused, as in S. cerevisiae, intracellular accumulation of free glucose and of sugar phosphates and a rapid drop of the ATP and inorganic phosphate levels. Glucose transport kinetics were the same for the wild type and the Klggs1 mutant in both derepressed cells and in cells incubated with glucose. We have isolated phenotypic revertants of the Klggs1 mutant for growth on fructose. The suppressors that we characterized had, to different extents, diminished glucose uptake in derepressed cells but cells incubated in glucose showed very different characteristics. The suppressor mutations prevented deregulation of glycolysis in the Klggs1 mutant but not the accumulation of free glucose. The mutants with higher residual uptake activity showed partially restored induction of pyruvate decarboxylase and activation of potassium transport. (ABSTRACT TRUNCATED AT 400 WORDS)
Randomization, Endogeneity and Laboratory Experiments

In conducting experiments with multiple trials, outcomes from previous trials can impact on current behavior. One of the most obvious cases in which this can happen, and the case considered in this paper, is in an auction market experiment, where earnings from previous auction trials alter cash balances which, in turn, can affect bidding behavior. (The most obvious mechanism for such a result, within standard theory, is if bidders are risk averse and do not have constant absolute risk aversion. One can imagine a number of non-standard reasons for such effects as well.) Use of OLS regressions with cash balances included as a right hand side variable are likely to lead to a biased estimate of the cash balance effect since the variation in cash balances is largely related to differences in bidding strategies across individuals. Fixed effect regressions can commonly control for these endogeniety problems at the potential cost of obtaining inefficient estimates, since this estimator does not exploit between-individual variation. This paper addresses this problem in two ways. First we consider an experimental design that reduces the potential bias of OLS estimates while increasing the precision of fixed effect estimates. Second, we consider instrumental variables estimation of the cash balance effect where the instruments are produced by the experimental design. To the best of our knowledge, neither of these approaches has been explored in the experimental literature.