Miracle-dz/UniFAR-FTUs huggingface dataset:
Preparation and photodetection performance of high crystalline quality and large size β-Ga2O3 microwires

Ultrawide band gap semiconductors are promising solar-blind ultraviolet (UV) photodetector materials due to their suitable bandgap, strong absorption and high sensitivity. Here, β-Ga2O3 microwires with high crystal quality and large size were grown by the chemical vapor deposition (CVD) method. The microwires reach up to 1 cm in length and were single crystalline with low defect density. Owing to its high crystal quality, a metal–semiconductor–metal photodetector fabricated from a Ga2O3 microwire showed a responsivity of 1.2 A/W at 240 nm with an ultrahigh UV/visible rejection ratio (R peak/R 400 nm) of 5.8 × 105, indicating that the device has excellent spectral selectivity. In addition, no obvious persistent photoconductivity was observed in the test. The rise and decay time constants of the device were 0.13 and 0.14 s, respectively. This work not only provides a growth method for high-quality Ga2O3 microwires, but also demonstrates the excellent performance of Ga2O3 microwires in solar-blind ultraviolet detection.
The effects of various parameters in sensitivity analysis of plain concrete beam using rigid body spring model

The Rigid Body Spring Model (RBSM) is an alternative method to Finite Element Model (FEM) to solve continuum problems in civil engineering. The method has three main advantages, i.e., having a smaller local stiffness matrix, the ability to directly simulate cracks, and independent formulation of element types. Although the method has been extensively used in studying the behaviour of concrete structures, specific research on sensitivity analysis of this method has not been done nor published. In this research, sensitivity analysis of plain concrete beam using the model is performed. The parameters to be considered are boundary size, boundary element type, number of elements, crack mesh refinement, number of stages, and the effect of half modelling. Based on the sensitivity analysis, optimum parameters were selected to calibrate the model to three plain concrete samples. The result suggests that modulus elasticity of cylindrical concrete under compressive test is to be reduced around 0.2 times for simulating beam under third point loading.
Recent advances in NiO/Ga2O3 heterojunctions for power electronics

Beta gallium oxide (β-Ga2O3) has attracted significant attention for applications in power electronics due to its ultra-wide bandgap of ~ 4.8 eV and the large critical electric field of 8 MV/cm. These properties yield a high Baliga’s figures of merit (BFOM) of more than 3000. Though β-Ga2O3 possesses superior material properties, the lack of p-type doping is the main obstacle that hinders the development of β-Ga2O3-based power devices for commercial use. Constructing heterojunctions by employing other p-type materials has been proven to be a feasible solution to this issue. Nickel oxide (NiO) is the most promising candidate due to its wide band gap of 3.6–4.0 eV. So far, remarkable progress has been made in NiO/β-Ga2O3 heterojunction power devices. This review aims to summarize recent advances in the construction, characterization, and device performance of the NiO/β-Ga2O3 heterojunction power devices. The crystallinity, band structure, and carrier transport property of the sputtered NiO/β-Ga2O3 heterojunctions are discussed. Various device architectures, including the NiO/β-Ga2O3 heterojunction pn diodes (HJDs), junction barrier Schottky (JBS) diodes, and junction field effect transistors (JFET), as well as the edge terminations and super-junctions based on the NiO/β-Ga2O3 heterojunction, are described.
Partial resistance tempering of hot-stamped components made of 22MnB5 for subsequent bending

The manganese-boron alloy 22MnB5 is particularly used for structural and safety-relevant parts in the automotive industry. Parts made from this alloy are usually produced using the hot forming process. Here, the sheet is heated to over 950 °C using an industrial roller hearth furnace. The heated sheet is then simultaneously formed and quenched in a cooled tool with a temperature gradient of more than 27 K/s. This leads to the formation of a martensitic microstructure with a hardness value of over 450 HV10 and an elongation at break of less than 6%. The small strain potential of such components makes them difficult to form after hot-stamping. Due to the high temperature gradients of resistance heating, a sheet can be heat-treated locally without a large temperature transition zone. This can be used to locally soften already hot-stamped components for subsequent operations such as bending. Within the scope of this paper, resistance heating is used to soften a hot-stamped 22MnB5+AlSi sheet stripe of 3 mm width. The sheet could consequently be bent over an angle of 90° without cracking the substrate.
Collateral damage: has the COVID-19 pandemic more strongly impacted medical research than other scientific areas?

The principle of resource allocation states that diversion of resources to attend a function may compromise others. The COVID-19 pandemic required a rapid response with a justifiable relocation of equipment, funds and human resources. Based on the ecological principle of allocation, we tested whether the relocation of resources to support COVID-19 research was more detrimental to medical research than to research in other scientific areas. We compared the yearly number of published articles from 2015 to 2021 using disease-related keywords and non-medical scientific keywords. Contrary to the expectation, we found an abrupt reduction in the publication rates in all research areas from 2019 to 2020 or 2021, compared to the pre-pandemic period (2015–2019). The allocation effect on medical research may be overshadowed by stronger effects of the pandemic, or it may become evident in the coming years. The drastic reduction in published papers could have negative consequences for scientific advancements, including understanding and curing diseases other than COVID-19 that strongly affect humanity.
Battery-free and AI-enabled multiplexed sensor patches for wound monitoring

Wound healing is a dynamic process with multiple phases. Rapid profiling and quantitative characterization of inflammation and infection remain challenging. We report a paper-like battery-free in situ AI-enabled multiplexed (PETAL) sensor for holistic wound assessment by leveraging deep learning algorithms. This sensor consists of a wax-printed paper panel with five colorimetric sensors for temperature, pH, trimethylamine, uric acid, and moisture. Sensor images captured by a mobile phone were analyzed by neural network–based machine learning algorithms to determine healing status. For ex situ detection via exudates collected from rat perturbed wounds and burn wounds, the PETAL sensor can classify healing versus nonhealing status with an accuracy as high as 97%. With the sensor patches attached on rat burn wound models, in situ monitoring of wound progression or severity is demonstrated. This PETAL sensor allows early warning of adverse events, which could trigger immediate clinical intervention to facilitate wound care management.
A Computational Investigation of Occlusive Arterial Thrombosis

The generation of occlusive thrombi in stenotic arteries involves the rapid deposition of millions of circulating platelets under high shear flow. The process is mediated by the formation of molecular bonds of several distinct types between platelets; the bonds capture the moving platelets and stabilize the growing thrombi under flow. We investigated the mechanisms behind occlusive thrombosis in arteries with a two-phase continuum model. The model explicitly tracks the formation and rupture of the two types of interplatelet bonds, the rates of which are coupled with the local flow conditions. The motion of platelets in the thrombi results from competition between the viscoelastic forces generated by the interplatelet bonds and the fluid drag. Our simulation results indicate that stable occlusive thrombi form only under specific combinations for the ranges of model parameters such as rates of bond formation and rupture, platelet activation time, and number of bonds required for platelet attachment.
Innovative protocol of an exploratory study evaluating the acceptability of a humanoid robot at home of deaf children with cochlear implants

The purpose of this paper is to introduce a research methodology for the assessment of the acceptability of a humanoid robot at home for children with cochlear implants (CI). The quality of audiology rehabilitation for cochlear implanted child administrated at the hospital with pluri-weekly sessions is a major prognostic factor in the outcome on communications abilities, but represents also a constraint for families related to the access to care that are more difficult. Further, home training with tools would balance the equitable distribution of care in the territory and promote the child’s progress. The humanoid robot should allow an ecological approach to this complementary training. Before developing this approach, it is necessary to study the acceptability of the humanoid robot at home, both by cochlear implanted child and their families. Ten families were chosen to have a humanoid robot at home, to explore their acceptability of the humanoid robot Pepper. The study lasts for 1 month per participants (i.e. cochlear implemented children and parent). Participants were invited to use the robot at home as much as they want. The humanoid robot Pepper was able to communicate and proposed activities not related to rehabilitation. Once a week during the study, data were collected from participants (questionnaires and robot’s logs) and the smooth running of the study was checked. Questionnaires are used to evaluate the acceptability of the robot by children and parents. User data from the robot’s logs are used to quantify the time and the actual use of the robot over the period of the study. Results of the experimentation will be reported, once all 10 participants have completed their passation. The robot is anticipated to be used and accepted by children with cochlear implants and their families. Clinical trial registration: Clinical Trials ID: NCT04832373; https://clinicaltrials.gov/.
Cell competition for neuron-derived trophic factor controls the turnover and lifespan of microglia

Microglia are brain-resident macrophages capable of long-term maintenance through self-renewal. Yet the mechanism governing the turnover and lifespan of microglia remains unknown. In zebrafish, microglia arise from two sources, rostral blood island (RBI) and aorta-gonad-mesonephros (AGM). The RBI-derived microglia are born early but have a short lifespan and diminish in adulthood, while the AGM-derived microglia emerge later and are capable of long-term maintenance in adulthood. Here, we show that the attenuation of RBI microglia is due to their less competitiveness for neuron-derived interleukin-34 (Il34) caused by age-dependent decline of colony-stimulating factor-1 receptor a (csf1ra). Alterations of Il34/Csf1ra levels and removal of AGM microglia revamp the proportion and lifespan of RBI microglia. The csf1ra/CSF1R expression in zebrafish AGM-derived microglia and murine adult microglia also undergo age-dependent decline, leading to the elimination of aged microglia. Our study reveals cell competition as a general mechanism controlling the turnover and lifespan of microglia.
Spectral analysis of multiple scattering factors of turbid media for glucose measurement using near-infrared spectroscopy

Abstract. Significance Near-infrared (NIR) diffuse reflectance spectroscopy has been widely used for non-invasive glucose measurement in humans, as glucose can induce a significant and detectable optical signal change in tissue. However, the scattering-dominated glucose spectrum in the range of 1000 to 1700 nm is easily confused with many other scattering factors, such as particle density, particle size, and tissue refractive index. Aim Our aim is to identify the subtle distinctions between glucose and these factors through theoretical analysis and experimental verification, in order to employ suitable methods for eliminating these interferences, thus increasing the accuracy of non-invasive glucose measurement. Approach We present a theoretical analysis of the spectra of 1000 to 1700 nm for glucose and some scattering factors, which is then verified by an experiment on a 3% Intralipid solution. Results We found that both the theoretical and experimental results show that the effective attenuation coefficient of glucose has distinct spectral characteristics, which are distinct from the spectra caused by particle density and refractive index, particularly in the range of 1400 to 1700 nm. Conclusions Our findings can offer a theoretical foundation for eliminating these interferences in non-invasive glucose measurement, aiding mathematical methods to model appropriately and enhance the accuracy of glucose prediction.
A prognostic signature associated with cell senescence predicts survival outcomes and strongly associates with immunotherapy and chemotherapy response in breast cancer

The objective of this study is to assess the predictive potency of cell senescence-related genes (CSRGs) in breast cancer (BC) and establish a risk signature. Trascriptome data of CSRGs were obtained from the TCGA and GEO databases. Consensus clustering was used to generate CSRGs-based molecular clusters for BC patients. A CSRGs-derived risk signature was built using multiple Cox regression analyses of differentially expressed genes (DEGs) between clusters. The prognosis, immune infiltration, chemotherapy and immunotherapy response between different risk groups were analyzed and compared. Two molecular clusters of BC patients were generated on the basis of 79 differentially expressed CSRGs, which showed distinct prognosis and immune infiltration. A total of 1403 DEGs between the CSRGs-derived clusters were found, and 10 of them were independent prognostic genes that used to construct a risk signature. The results demonstrated that patients with older age and advanced stage presented with a higher risk scores. In addition, the risk signature was found to be associated with outcomes, immune infiltration, chemotherapy and immunotherapy response. Patients in the low-risk group showed a favorable prognosis and higher immunotherapy response than those in the high-risk group. Finally, we developed a highly stable nomogram that incorporates risk signature, chemotherapy, radiotherapy, and stage variables, enabling accurate prediction of the overall survival (OS) of individual patients. To conclude, the signature derived from CSRGs holds great promise as a biomarker for prognostic assessment of BC and may serve as a valuable tool in guiding immunotherapy.
Three-Dimensional Automated Contour Detection for Global Systolic Dyssynchrony Index Measurements

Background: Left ventricular dyssynchrony (LVD) has become a therapeutic target using biventricular pacing in selected heart failure patients. Recent advances in 3-dimensional echocardiography (3DE) and automated border detection (ABD) techniques have simplified quantification of global LVD. However, the accuracy and reproducibility of 3DE with ABD for measuring LVD have not been evaluated before. Methods: The 3DE data for 50 patients were analyzed offline by 2 independent observers. Systolic dyssynchrony index (SDI) was determined by 3-dimensional ABD (3ABD) and 2-dimensional ABD (2ABD) with different imaging planes(2, 4, 6, 8, 12, 16 and 32). Data for 2-, 4-, 6-, 8-, 12-, 16- and 32-plane assessmentswere compared to those for 3ABD approach and repeat measurements. Results: Biplane, 4-plane, and 6-plane assessment tended to overestimate SDI. As measured by 8-, 12-, 16- and 32-plane methods, SDI exhibited no significant difference and excellent correlation. The 3DE with 3ABD produced lower intra-observer and inter-observer variability (intra-observer: 7.9 and 14.8; inter-observer: 9.8 and 16.4 for 3ABD and 8-plane, respectively). Total time for 3ABD approach (3.1 0.6 min) was shorter than conventional 8-plane (14.4 1.2 min, P < 0.001) approach. Conclusion: Accurate quantification of SDI can be obtained from 3DE using 3ABD or 2ABD with as few as 8 planes. To assess SDI, 3DE using 3ABD exhibited better reproducibility than 3DE using 2ABD. Therefore, 3DE assessment using 3ABD is the preferred approach when evaluating global LVD is necessary. Further prospective study is necessory to demonstrate whether this SDI by 3ABD is a predictor of cardiac resynchronization therapy outcome or not.
A first-generation genome-wide map of correlated DNA methylation demonstrates highly coordinated and tissue-independent clustering across regulatory regions

Genome-wide DNA methylation studies have typically focused on quantitative assessments of CpG methylation at individual loci. Although methylation states at nearby CpG sites are known to be highly correlated, suggestive of an underlying coordinated regulatory network, the extent and consistency of inter-CpG methylation correlation across the genome, including variation between individuals, disease states, and tissues, remains unknown. Here, we leverage image conversion of correlation matrices to identify correlated methylation units (CMUs) across the genome, describe their variation across tissues, and annotate their regulatory potential using 35 public Illumina BeadChip datasets spanning more than 12,000 individuals and 26 different tissues. We identified a median of 18,125 CMUs genome-wide, occurring on all chromosomes and spanning a median of ~1 kb. Notably, 50% of CMUs had evidence of long-range correlation with other proximal CMUs. Although the size and number of CMUs varied across datasets, we observed strong intra-tissue consistency among CMUs, with those in testis encompassing those seen in most other tissues. Approximately 20% of CMUs were highly conserved across normal tissues (i.e. tissue independent), with 73 loci demonstrating strong correlation with non-adjacent CMUs on the same chromosome. These loci were enriched for CTCF and transcription factor binding sites, always found within putative TADs, and associated with the B compartment of chromosome folding. Finally, we observed significantly different, but highly consistent, patterns of CMU correlation between diseased and non-diseased states. Our first-generation, genome-wide, DNA methylation map suggests a highly coordinated CMU regulatory network that is sensitive to disruptions in its architecture.
An Image Automatic Matching Method Based on FAST Corner and LBP Descriptor

An automatic image matching based on Features from Accelerated Segment Test (FAST) corner detector and Local Binary Patterns (LBP) Descriptor is proposed in this paper. Firstly, constructing gauss pyramid of the reference image and the image to match, then detecting and extracting the FAST corner points of both images, and calculating the LBP descriptors of the corner points, following by searching match point pairs by K-D tree. Thirdly, using random sample consensus algorithm to remove error point pairs and then calculate the geometry transform coefficients. Lastly, executing the geometry transform to get the matching image. Experimental result proves that this method has higher matching accuracy, higher matching efficiency, good scale invariance and illumination invariance.
Jackknife empirical likelihood test for mean residual life functions

ABSTRACT Mean residual life (MRL) function is an important function in survival analysis which describes the expected remaining life given survival to a certain age. In this article, we propose a non parametric method based on jackknife empirical likelihood through a U-statistic to test the equality of two mean residual functions. The asymptotic distribution of the test statistic has been derived. Simulations are conducted to illustrate the performance of the proposed test under different distributional assumptions and compare with some existing method. The proposed method is then applied to two real datasets.
The effect of curcumin-piperine on cardiometabolic, inflammatory and oxidative stress factors and macular vascular density in optical coherence tomography angiography (OCTA) in patients with non-proliferative diabetic retinopathy: Study protocol for a randomized, double-blind controlled trial

Objective: Curcumin is a safe phytochemical with antioxidant, anti-inflammatory, antidiabetic, and lipid-lowering effects. This study aims to investigate the efficacy of curcumin-piperine in non-proliferative diabetic retinopathy. Materials and Methods: In this double-blind randomized trial, 60 diabetic retinopathy patients after meeting the inclusion criteria will be randomly assigned to two groups of curcumin-piperine supplementation (1000 mg per day for 12 weeks) or receiving placebo. The density of small blood vessels in the retina by optical coherence tomography angiography (OCTA), fasting blood glucose, triglyceride, renal indices (blood urea nitrogen and creatinine), high-sensitivity C-reactive protein, total antioxidant capacity, total oxidant status, body mass index, waist circumference, and weight will be measured. Conclusion: If the beneficial effects of curcumin on diabetic retinopathy are observed, this safe, this natural and inexpensive herbal supplement can be considered a therapeutic solution in these patients.
Implementation of EPR-Youth, a Client-Accessible and Multidisciplinary Health Record; A Mixed-Methods Process Evaluation

Introduction: Client-accessible interdisciplinary health records potentially contribute to integrated care by facilitating collaboration and enhancing clients’ involvement in care. To achieve this, three Dutch organizations providing ‘care for youth’ developed a fully client-accessible electronic patient record (EPR-Youth). Objective: To evaluate the implementation of EPR-Youth and to determine barriers and facilitators. Methods: A mixed methods design combined system data, process observations, questionnaires and focus group interviews. Target groups were parents, adolescents, professionals using EPR-Youth, and implementation stakeholders. Findings: Client-portal acceptability was high among all clients. Client-portal adoption rate was high and differed between age groups and educational levels. Professionals’ doubts about acceptability, appropriateness and fidelity were partly due to lack of system knowledge. Implementation barriers were the complexity of co-creation, lack of clear leadership, and concerns about legal issues. Facilitators were clarifying vision and legal context, setting deadlines, and a pioneering spirit. Conclusion: The early implementation of EPR-Youth, the first Dutch client-accessible interdisciplinary electronic health record in ‘care for youth’ was successful. To enhance adoption among clients, group-specific barriers for portal-use should be determined. Professionals need additional training. Further research is needed to gain insight into client-portal access barriers. To benefit more from co-creation, an organizational change towards situational leadership is necessary.