Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Multispecies Probiotic Supplements on Metabolic Profiles, hs-CRP, and Oxidative Stress in Patients with Type 2 Diabetes

Background: We are aware of no study that has indicated the effects of daily consumption of multispecies probiotic supplements on metabolic profiles, high-sensitivity C-reactive protein (hs-CRP), and oxidative stress in diabetic patients. Objective: This study was designed to determine the effects of multispecies probiotic supplements on metabolic profiles, hs-CRP, and oxidative stress in diabetic patients. Methods: This randomized double-blind placebo-controlled clinical trial was performed on 54 diabetic patients aged 35-70 years. Subjects were randomly assigned to take either a multispecies probiotic supplement (n = 27) or placebo (n = 27) for 8 weeks. The multispecies probiotic supplement consisted of 7 viable and freeze-dried strains: Lactobacillus acidophilus (2 × 109 CFU), L. casei (7 × 109 CFU), L. rhamnosus (1.5 × 109 CFU), L. bulgaricus (2 × 108 CFU), Bifidobacterium breve (2 × 1010 CFU), B. longum (7 × 109 CFU), Streptococcus thermophilus (1.5 × 109 CFU), and 100 mg fructo-oligosaccharide. Fasting blood samples were taken at baseline and after intervention to measure metabolic profiles, hs-CRP, and biomarkers of oxidative stress including plasma total antioxidant capacity and total glutathione (GSH). Results: Between-group comparisons of fasting plasma glucose (FPG) revealed that consumption of probiotic supplements prevented a rise in FPG (+28.8 ± 8.5 for placebo vs. +1.6 ± 6 mg/dl for probiotic group, p = 0.01). Although a significant within-group increase in serum insulin and low-density lipoprotein cholesterol levels was found in both the probiotic group and the placebo group, the changes were similar between the two groups. We observed a significant increase in HOMA-IR (homeostasis model of assessment-insulin resistance) in both the probiotic group (p = 0.02) and the placebo group (p = 0.001); however, the increase in the placebo group was significantly higher than that in the probiotic group (+2.38 vs. +0.78, p = 0.03). Mean changes in serum hs-CRP were significantly different between the two groups (-777.57 for the probiotic group vs. +878.72 ng/ml for the placebo group, p = 0.02). Probiotic supplementation led to a significant increase in plasma GSH levels compared to placebo (240.63 vs. -33.46 µmol/l, p = 0.03). Conclusion: In conclusion, multispecies probiotic supplementation, compared with placebo, for 8 weeks in diabetic patients prevented a rise in FPG and resulted in a decrease in serum hs-CRP and an increase in plasma total GSH.
SuGAR: A Framework to Support Mammogram Diagnosis

In this paper we present a framework based on association-rules to help diagnosis of mammogram abnormalities. Our framework - SuGAR - combines low-level features automatically extracted from images with high-level knowledge gotten from specialists to mine association rules, suggesting possible diagnoses. Our framework is optimized, in the sense that it combines, in a single step, feature selection and discretization, reducing the mining complexity. The framework was applied to real datasets and the results show high sensitivity (up to 95%) and accuracy (up to 92%), allowing us to claim that association rules can effectively aid in the diagnosing task.
Deoxycoformycin induces long-lasting remissions in hairy cell leukemia: clinical and biological results of two different regimens.

The use of alpha interferon (alpha IFN) and, more recently, of the purine analogues deoxycoformycin (dCF) and 2-chlorodeoxyadenosine (2-CdA) has dramatically improved the prognosis of patients affected by hairy cell leukemia (HCL). DCF has been shown to induce an higher and more durable response rate than IFN, with only moderate myelosuppression and relatively few side effects. In this paper, we report our experience with dCF in a series of 38 HCL patients who had progression of their disease after IFN therapy. Serum interleukin-1 beta (IL-1 beta), soluble interleukin-2 receptors (sIl-2R) and Tumor Necrosis Factor alpha (TNF alpha) levels were also evaluated before, both during and after treatment in order to monitor clinical response. Two schedules of treatment were employed: 23 patients were treated with the EORTC protocol and the following 15 with the NCI regimen. The overall response rate was 94.7%; no significant differences in response rates were observed between the two schedules. In respect to toxicity, we recorded nausea and in two cases a cutaneous rash. Four patients experienced localized herpes zoster and one had a fungal pneumonia. Median overall survival after therapy is 38.5 months, 55 percent of patients enrolled in the EORTC schedule and 77% of those who received the NCI program are currently in CCR at 3 years. Serum IL-1 beta and sIL-2R levels significantly decreased after treatment, while no significant changes in serum TNF alpha levels were observed. In our study, dCF was confirmed as an effective agent in HCL, inducing an high response rate with only moderate side effects. (ABSTRACT TRUNCATED AT 250 WORDS)
Effect of resveratrol and pterostilbene on aging and longevity

Over the past years, several studies have found that foods rich in polyphenols protect against age‐related disease, such as atherosclerosis, cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2 diabetes (T2D), hypertension and Alzheimer's disease. Resveratrol and pterostilbene, the polyphenol found in grape and blueberries, have beneficial effects as anti‐aging compounds through modulating the hallmarks of aging, including oxidative damage, inflammation, telomere attrition and cell senescence. In this review, we discuss the relationship between resveratrol and pterostilbene and possible aging biomarker, including oxidative stress, inflammation, and high‐calorie diets. Moreover, we also discuss the positive effect of resveratrol and pterostilbene on lifespan, aged‐related disease, and health maintenance. Furthermore, we summarize a variety of important mechanisms modulated by resveratrol and pterostilbene possibly involved in attenuating age‐associated disorders. Overall, we describe resveratrol and pterostilbene potential for prevention or treatment of several age‐related diseases by modulating age‐related mechanisms. © 2017 BioFactors, 44(1):69–82, 2018
New Strategies for Initialization and Training of Radial Basis Function Neural Networks

In this paper we proposed two new strategies for initialization and training of Radial Basis Function (RBF) Neural Network. The first approach takes into consideration the "error" between the input vector p of the network and the x-axis, which are the centers of radial functions. The second approach takes into account the "error" between the input vector p and the network output. In order to check the performances of these strategies, we used Brazilian financial market data for the RBF networks training, specifically the adjusted prices of the 10 greater weighted shares in the Bovespa index at the time of data collection ‑ from April 8th, 2009 to October 31th, 2014. The first approach presented a 52% of improvement in the mean squared error (MSE) compared to the standard RBF network, while the improvement for the second approach was 38%. The strategies proved to be consistent for the time series tested, in addition to having a low computational cost. It is proposed that these strategies be improved by testing them with the Levenberg-Marquardt algorithm.
Cloning of murine NKG2A, B and C: second family of C‐type lectin receptors on murine NK cells

Multiple NK cell receptors for MHC class I have been identified. They include killer inhibitory receptors and CD94/NKG2 heterodimers in humans and the Ly49 family in mice. Here we report the cloning of murine NKG2A, B and C. The deduced amino acid sequence of mouse NKG2A contains only one consensus cytoplasmic immunoreceptor tyrosine‐based inhibitory motif (ITIM). NKG2A from B6 and BALB/c mice differ by six amino acid residues in the extracellular domain. Murine NKG2B, like its human conterpart, appears to be a splice variant of NKG2A and lacks a large portion of the stalk region. Murine NKG2C lacks an ITIM in its cytoplasmic domain, a feature shared by human and rat NKG2C. However, unlike the human counterpart, the transmembrane domain of mouse NKG2C does not contain a charged amino acid residue. Mouse NKG2A mRNA was detected in IL‐2‐activated NK cells and spleen cells but not in other tissues. The NKG2A gene was localized on the distal portion of chromosome 6 where the NK complex has been located. These results further extend the repertoire of C‐type lectin receptors on murine NK cells.
The Level of Virus-Specific T-Cell and Macrophage Recruitment in Porcine Reproductive and Respiratory Syndrome Virus Infection in Pigs Is Independent of Virus Load

ABSTRACT Porcine reproductive and respiratory syndrome virus (PRRSV) is the most important infectious disease agent of pigs worldwide, causing reproductive failure in pregnant sows and respiratory problems in nursing and growing pigs. PRRSV infection is characterized by a prolonged viremia of 30 or more days and an extended persistent infection of lymphoid tissues. To better understand the immunological basis for prolonged acute and persistent PRRSV infection, we have examined the cell-mediated immune (CMI) response throughout the course of infection and compared the results to the local distribution and abundance of PRRSV in infected tissues. PRRSV-specific T cells, enumerated by gamma interferon enzyme-linked immunospot assay, did not appear until 2 weeks after PRRSV inoculation, and their abundance exhibited substantial variation over time and among animals. In all cases the T-cell response was transient. High levels of viral RNA were present in lymphoid tissues of all animals in the acute phase of infection. Viral loads were decreased 1,000-fold or more in persistent infections, with the primary sites of persistence being tonsil, sternal lymph node, and inguinal lymph node. The abundance of virus-specific T cells in either acutely or persistently infected animals was highly variable and showed no correlation to the level of virus in lymphoid tissues. No significant difference in antigen-specific T-cell abundance was observed in secondary lymphoid tissues in either acute or persistent infection except for tonsil, in which the number of responding cells was extremely low. CD4+- and CD8+-T-cell frequencies did not change after PRRSV infection, though a decrease in γδ T cells was observed. Macrophages, the permissive cell type for PRRSV, were present in various levels in all tissue preparations and were not in proportion to local virus load. These findings indicate that a weak CMI response contributes to prolonged PRRSV infection and suggests that PRRSV suppresses T-cell recognition of infected macrophages. Thus, the slow but eventual resolution of PRRSV infection may be dependent on limiting permissive macrophages and on innate immune factors.
Low-density lipoprotein postsecretory modification, monocyte function, and circulating adhesion molecules in type 2 diabetic patients with and without macrovascular complications: the effect of alpha-tocopherol supplementation.

BACKGROUND Although diabetes confers an increased propensity toward accelerated atherogenesis, data are lacking on monocyte activity in type 2 diabetic patients with (DM2-MV) and without (DM2) macrovascular disease compared with control subjects. Thus, we tested whether (1) postsecretory modifications of LDL (glycation and oxidation), monocyte proatherogenic activity, and circulating levels of soluble cell adhesion molecules (sCAMs) are more pronounced in DM2-MV than in DM2 and control subjects and (2) RRR-alpha-tocopherol (AT) therapy, 1200 IU/d for 3 months, has a similar effect in the 3 groups (n=25 per group). METHODS AND RESULTS Although LDL glycation was increased in both diabetic groups compared with control subjects, AT therapy had no significant effect on glycation. AT therapy significantly decreased LDL oxidizability in all 3 groups. Diabetic monocytes released significantly more superoxide anion (O(2)(-)) and interleukin-1beta (IL-1beta) and exhibited greater adhesion to endothelium than control subjects. AT therapy significantly decreased the release of O(2)(-), IL-1beta, tumor necrosis factor-alpha, and monocyte-endothelium adhesion in all 3 groups. There was no significant difference between the 2 diabetic groups for any of the above parameters. sICAM levels were significantly elevated in both diabetic groups compared with controls. AT therapy resulted in a significant decrease in sCAMs. CONCLUSIONS This is the first demonstration of increased IL-1beta secretion and increased adhesion of monocytes to endothelium from normotriglyceridemic diabetic subjects and of decreased monocyte activity and sCAMs with AT therapy in diabetic subjects with and without macrovasculopathy.
Fiscal Reforms in Low-Income Countries

The reform of fiscal policies and institutions lies at the heart of structural adjustment in developing countries. Although the immediate aim of such reform is to reduce fiscal imbalances to achieve macroeconomic stability, the long-term goal is to secure more durable improvements in fiscal performance. This study reviews the fiscal reform experience of 36 low-income developing countries that undertook macroeconomic and structural adjustment in the context of the IMF's Structural Adjustment Facility and Enhanced Structural Adjustment Facility during the period of 1985-95.
The Dnmt1 DNA-(cytosine-C5)-methyltransferase Methylates DNA Processively with High Preference for Hemimethylated Target Sites*

In the cell, Dnmt1 is the major enzyme in maintenance of the pattern of DNA methylation after DNA replication. Evidence suggests that the protein is located at the replication fork, where it could directly modify nascent DNA immediately after replication. To elucidate the potential mechanism of this process, we investigate the processivity of DNA methylation and accuracy of copying an existing pattern of methylation in this study using purified Dnmt1 and hemimethylated substrate DNA. We demonstrate that Dnmt1 methylates a hemimethylated 958-mer substrate in a highly processive reaction. Fully methylated and unmethylated CG sites do not inhibit processive methylation of the DNA. Extending previous work, we show that unmethylated sites embedded in a hemimethylated context are modified at an approximately 24-fold reduced rate, which demonstrates that the enzyme accurately copies existing patterns of methylation. Completely unmodified DNA is methylated even more slowly due to an allosteric activation of Dnmt1 by methylcytosine-containing DNA. Interestingly, Dnmt1 is not able to methylate hemimethylated CG sites on different strands of the DNA in a processive manner, indicating that Dnmt1 keeps its orientation with respect to the DNA while methylating the CG sites on one strand of the DNA.
Relación flujos-desempeño en fondos de pensiones y fondos de inversión de España

The objective of this study is to analyze if investors of pension funds and investment funds consider the performance achieved by the fund in the same way as when they make decisions on investments. Specifically, throughout this paper, we compare different performance measures and analyze the relationship between flows and performance from a comparative view among spanish pension funds and investment funds of global equity, from January 1999 until December 2013. Additionally, we study whether the results change depending on the size of the funds and their position in the market, perceiving certain differences by size, especially in small funds. Results show that, although the performance of investment funds is a little superior, both types of investors consider the performance achieved by the fund for making an investment decision. Finally, this study concludes that pension investors penalize that the fund goes away from the index of reference, while investment funds members reward good marks, regardless of the result in relation to the market.
Chaos and Order in the Capital Markets: A New View of Cycles, Prices, and Market Volatility

THE NEW PARADIGM Introduction: Life Can Be So Complicated Random Walks and Efficient Markets The Failure of the Linear Paradigm Markets and Chaos: Chance and Necessity FRACTAL STRUCTURE IN THE CAPITAL MARKETS Introduction to Fractals The Fractal Dimension Fractal Time Series Biased Random Walks R/S Analysis of the Capital Markets Fractal Statistics Fractals and Chaos NONLINEAR DYNAMICS Introduction to Nonlinear Dynamic Systems Dynamic Analysis of Time Series Dynamic Analysis of the Capital Markets LIVING WITH COMPLEXITY The Coherent Market Hypothesis Fractional Truth: Fuzzy Logic and Behavioral Finance Applying Chaos and Nonlinear Methods What Lies Ahead: Toward a More General Approach About the Diskette Appendices Bibliography Glossary Index.
Terror in the Name of God: Why Religious Militants Kill

For four years, Jessica Stern interviewed extremist members of three religions around the world: Christians, Jews, and Muslims. Traveling extensively-to refugee camps in Lebanon, to religious schools in Pakistan, to prisons in Amman, Asqelon, and Pensacola-she discovered that the Islamic jihadi in the mountains of Pakistan and the Christian fundamentalist bomber in Oklahoma have much in common. Based on her vast research, Stern lucidly explains how terrorist organizations are formed by opportunistic leaders who-using religion as both motivation and justification-recruit the disenfranchised. She depicts how moral fervor is transformed into sophisticated organizations that strive for money, power, and attention. Jessica Stern's extensive interaction with the faces behind the terror provide unprecedented insight into acts of inexplicable horror, and enable her to suggest how terrorism can most effectively be countered. A crucial book on terrorism, Terror in the Name of God is a brilliant and thought-provoking work.
Investigation of interconnect parameters for high speed microelectronics devices applications

The present paper reports the optimization and analysis of the interconnect parameters such as ground and coupling capacitance which play very important roll in the design and development of future microelectronics devices. Here, we have optimized ground capacitance along with the variation in dielectric thickness and interwire spacing respectively. It has been observed that ground capacitance increases with increase in interwire spacing. It is also find out that the ground capacitance decreases with simultaneously increase in dielectric thickness.
Time for a change? Predictors of child care changes by low-income families

Instability in child care arrangements can negatively affect children's development, especially in low-income families. However, few studies have examined what predicts changes over time in child care arrangements. This paper presents findings from a unique multiyear study tracking child care use in low-income families. We estimate rich quantitative models to analyze the relationships among child, household, and care provider characteristics and four different types of changes. We find turnover in child care arrangements to be common in this low-income population. Over a period of six months, half of the children changed primary provider. Child care changes were frequently related to job loss, changes in family composition, or the changing availability of caregivers. While concerns have been raised that short spells of child care subsidy receipt cause child care instability, we found that subsidy use was not associated with higher rates of change. In addition, we found that the lower a parent's assessment of the child's experience in a particular arrangement in the prior time period, the higher the likelihood of changing providers by the next survey wave. These results indicate that low-income parents recognize quality factors and change arrangements to improve the quality of care.
Role of adult input in young children's category evolution: II an experimental study

ABSTRACT Young children's initial categories often are not identical to the adult category labelled by the same word. Eventually, children's categories must evolve to correspond to the adult standard. The purpose of this study was to consider the relative effectiveness of four input strategies in inducing the child to learn the adult-appropriate label and begin to form a new category. Fifty-six children aged 2;0 were taught new labels for objects that they included in categories labelled by different names. Comprehension and production post-tests were then administered. As expected, the most effective strategy involved labelling an object and providing both a physical demonstration and a verbal description of important attributes that made the object a member of the adult-appropriate category. The label plus physical demonstration strategy was next most effective. Neither the label plus verbal description strategy nor the label only strategy was effective for children of this age. Results also indicated that these 24 month olds did not yet honour the convention of mutual exclusivity of basic level categories.
Casual Employment in Australia: A Further Analysis

Casual employment is steadily increasing its share of total employment in Australia. This paper analyses some of the factors that have led to this situation by extending the work of Simpson, Dawkins and Madden (1997). The results, while confirming some of their research and clarifying the role of union membership in limiting the spread of casual employment, also show that the determinants of casual employment in Australia are sensitive to the period of estimation and the form of model used. Copyright 1999 by Blackwell Publishers Ltd/University of Adelaide and Flinders University of South Australia
Incidence of stroke and myocardial infarction in women of reproductive age.

BACKGROUND AND PURPOSE Information on the incidence of vascular disease in women of reproductive age has been limited. These disease are rare in this age group, and a large population base is required for reliable estimation of incidence. METHODS For a case-control study of vascular disease and low-dose oral contraceptive use, we used emergency department logs and hospital admission and discharge records to ascertain fatal and nonfatal cases of first-ever stroke and myocardial infarction (MI) in women 15 to 44 years of age who were-members of a large California HMO. Incidence rates of stroke and MI were calculated on the basis of these data. RESULTS The incidence of MI not associated with pregnancy was 5.0 per 100,000 women-years. The incidence of stroke not associated with pregnancy was 10.7 per 100,000 women-years. MI was very rare until age 35 years. At every age, about half of hemorrhagic strokes were due to subarachnoid hemorrhage. CONCLUSIONS The incidence rates of stroke and MI are low in women of reproductive age in the United States.
A NOTE ON BUBBLES, WORTHLESS ASSETS, AND THE CURIOUS CASE OF GENERAL MOTORS

Since the company declared bankruptcy in June 2009, shares of General Motors stock (now known as Motors Liquidation Company) have continued to trade at a high volume while maintaining a market capitalization near $300 million through most of 2010. Anecdotal evidence strongly suggests that both rational speculators and uninformed investors (often mistaking Motors Liquidation for the new, reorganized GM) have purchased the stock. We develop a theoretical asset-pricing model that includes both types of agents. We present two major results. First, the most frequent state is one where a small fraction of rational agents ensure that the share price behaves as if all agents are rational. A second state exists where all rational agents exit and the share price is inflated. Second, fitting the model to Motors Liquidation, we find evidence of irrational asset pricing for this firm. We find little evidence of similar behavior in the share prices of the thirty stocks that compose the Dow Jones Industrial Average.