Miracle-dz/UniFAR-FTUs huggingface dataset:
Processing information related to centrally initiated locomotor and voluntary movements by feline spinocerebellar neurones

Non‐technical summary For the correct execution of centrally initiated movements, it is vital that the cerebellum receives continuous feedback from the spinal cord. We recently demonstrated that a population of spinocerebellar neurones provides the cerebellum with feedback on the likely outcome of descending commands relayed via reticulospinal neurones. We now demonstrate that the same spinocerebellar neurones provide information on the likely outcome of commands from the corticospinal tract (pyramidal tract) neurones as well as from the mesencephalic locomotor region. The results indicate that both voluntary motor actions and those related to locomotion are relayed by reticulospinal neurones and are monitored by the same population of spinocerebellar neurons, which may thereby provide the brain with information necessary for avoiding errors in issuing movements.
PROFILES OF ANTIOXIDANT ISOENZYMES IN THE PATHOSYSTEM SCENEDESMUS – PHLYCTIDIUM AFTER TREATMENT WITH PLANT GROWTH REGULATORS

The present study was undertaken to investigate the possibilities of some plant growth regulators – abscisic acid, fluridone, methyl jasmonate, salicylic acid and the cytokinin 4-PU-30 to participate in the disease tolerance induction in the unicellular green alga Scenedesmus incrassatulus invaded with the unicellular fungal parasite Phlyctidium scenedesmi. We established that protein profiles in host cells changed drastically after the parasite invasion. Pretreatment of algal cells with PGR (4-PU-30 and MeJA) depressed the depletion of soluble proteins in Scenedesmus cells caused by Phlyctidium invasion. The presence of SA and MeJA in the cultivation medium caused a significant enhancement of the amount of the fastest moving thermostable protein band. In ABA-, fluridoneand 4-PU-30-pretreated invaded algal cells significant activation of peroxidase which plays an important role in resistance induction was observed. SA stopped catalase enhancement in the invaded cells. Parasite invasion was connected with both qualitative and quantitative changes in the spectrum of SOD. The data obtained support the suggestion that ABA, MeJA, 4-PU-30 and SA are involved in plant-pathogen interactions and acquisition of pathogen tolerance.
Evaluating the Chinese Version of the Teacher Sense of Efficacy Scale (C-TSE): Translation Adequacy and Factor Structure

This study subjected the Chinese version of the Teacher Sense of Efficacy Scale (C-TSE) to further empirical study in two ways. First, it assessed its translation adequacy and produced a new, reliable, and valid Chinese version. This was done by drawing on the original version and by employing more rigorous translation methods to identify and resolve translation problems. An expert panel was also employed to adjudicate on final translation and item selection issues. The new Chinese version is referred to in this article as the C-TSE(R). The C-TSE(R) was subjected to further analysis in order to assess its psychometric properties among a sample of Chinese teacher leaders. The results of an exploratory analysis showed a basic factor structure that differed from the one identified in the original English version of the instrument but quite consistent with that identified in the original C-TSE. A cultural explanation is advanced for this variation. The factor structure was also evaluated against those reported by related studies using the original C-TSE. The results of the study reported here suggest that C-TSE(R) is a valid and reliable instrument that, with further validation studies, could prove to be a very useful tool for assessing teacher sense of efficacy in Chinese societies.
Correlated Bursts of Activity in the Neonatal Hippocampus in Vivo

The behavior of immature cortical networks in vivo remains largely unknown. Using multisite extracellular and patch-clamp recordings, we observed recurrent bursts of synchronized neuronal activity lasting 0.5 to 3 seconds that occurred spontaneously in the hippocampus of freely moving and anesthetized rat pups. The influence of slow rhythms (0.33 and 0.1 hertz) and the contribution of both γ-aminobutyric acid A–mediated and glutamate receptor–mediated synaptic signals in the generation of hippocampal bursts was reminiscent of giant depolarizing potentials observed in vitro. This earliest pattern, which diversifies during the second postnatal week, could provide correlated activity for immature neurons and may underlie activity-dependent maturation of the hippocampal network.
A Novel Method to Generate and Expand Clinical-Grade, Genetically Modified, Tumor-Infiltrating Lymphocytes

Following the clinical success achieved with the first generation of adoptive cell therapy (ACT) utilizing in vitro expanded tumor-infiltrating lymphocytes (TILs), the second and third generations of TIL ACT are evolving toward the use of genetically modified TIL. TIL therapy generally involves the transfer of a high number of TIL, ranging from 109 to 1011 cells. One of the technical difficulties in genetically modifying TIL, using a retroviral vector, is the ability to achieve large expansion of transduced TIL, while keeping the technique suitable to a Good Manufacturing Practices (GMP) environment. Consequently, we developed and optimized a novel method for the efficient production of large numbers of GMP-grade, gene-modified TIL for the treatment of patients with ACT. The chemokine receptor CXCR2 was used as the gene of interest for methodology development. The optimized procedure is currently used in the production of gene-modified TIL for two clinical trials for the treatment of metastatic melanoma at MD Anderson Cancer Center.
A cell cycle-controlled redox switch regulates the topoisomerase IV activity

Narayanan et al. show in C. crescentus that NstA acts by binding to the ParC DNA-binding subunit of topoisomerase IV and inhibits its decatenation activity. They also uncover a dynamic oscillation of the intracellular redox state during the cell cycle, which correlates with and controls NstA activity.
Bidirectional organelle transport can occur in cell processes that contain single microtubules

Intracellular organelle transport was studied in a new model system, the giant freshwater ameba Reticulomyxa. The ameba extends a large reticulate network of cytoplasmic strands in which various phase-dense organelles can be seen to move at a rate of up to 25 microns/s. This combined light and high voltage electron microscopic study shows that organelles move bidirectionally in even the finest network strands that contain only a single microtubule. In terms of microtubule-associated intracellular transport, this observation defines a minimum set of conditions necessary for such movement. The implications of this finding for possible models of force generation are discussed.
On the Integration of Spectrum-Based Fault Localization Tools into IDEs

Spectrum-Based Fault Localization (SBFL) is a technique to be used during debugging, the premise of which is that, based on the test case outcomes and code coverage, faulty code elements can be automatically detected. SBFL is popular among researchers because it is lightweight and easy to implement, and there is a lot of potential in it when it comes to research that aims to improve its effectiveness. Despite this, the technique cannot be found in contemporary development and debugging tools, only a handful of research prototypes are available. Reasons for this can be multiple, including the algortihms' sub-optimal effectiveness and other technical weaknesses. But, also the lack of clear functional and non-functional requirements for such a tool, either standalone or integrated into IDEs. In this paper, we attempt to provide such a list in form of recommendations, based on surveying the most popular SBFL tools and on our own researchers' and tool builders' experience.
Where do Analysts Come from? The Case of Financial Chartism

probabilistic models of price movements were developed preponderantly in France, which – and this is a significant element – did not have a price recording technology comparable to the ticker. (In fact, it had none at least until the 1930s.) In France, abstract models of price variations emerged partly as a sign of distrust in the accuracy of price recordings, and partly as a more general distrust in statistics, which was seen as inferior to modeling (Desrosières, 1998, p. 282; Ménard, 1980, p. 534). Attempts to combine theoretical and statistical analysis of price movements, like that of Marcel Lenoir in 1913, were completely ignored in France (Desrosières, 1998, p. 283). Non-standardized, parallel price data, combined with a distrust of statistical data and a professional division between formal economic analysis (done in France mainly by engineers and actuaries, prone to modeling) and informal political economy (the domain of legally-trained French economists – see Breton, 1992, p. 32) contributed to the predominant position of formal modeling in France. In New York, however, technical analysis did not encounter initial serious competition from an incompatible explanatory model like Regnault’s and Bachelier’s probabilistic explanations. Chartists, too, distrusted statistics provided by companies and saw ticker price data as more reliable. In addition to this, however, they relied not on analytical principles borrowed from physics and/ or biology (although they paid lip service to the natural sciences), but rather on a tradition of ‘prophecy’, which mixed up practical experience with some statistical observations (see the place given to Benner’s ‘prophecies’). It could be conjectured here that this peculiar combination between technology and ‘prophecy’ (absent in France, where engineers and actuaries tried to compensate inaccurate data by abstract analysis) played a role in the emergence of chartism in a specific context. As stated above, the aim of technical analysis is to forecast price movements on the grounds of detailed price charts, starting from the principles that (1) patterns of price variations are repeatable and (2) these patterns occur in repeatable situations: A lot of people say that charts are of no value in determining the future; that they simply represent past history. That is correct; they are records of the past, but the future is nothing but a repetition of the past. Every business man goes on the past
Instabilities in the dissolution of a porous matrix

A reactive fluid dissolving the surrounding rock matrix can trigger an instability in the dissolution front, leading to spontaneous formation of pronounced channels or wormholes. Theoretical investigations of this instability have typically focused on a steadily propagating dissolution front that separates regions of high and low porosity. In this paper we show that this is not the only possible dissolutional instability in porous rocks; there is another instability that operates instantaneously on any initial porosity field, including an entirely uniform one. The relative importance of the two mechanisms depends on the ratio of the porosity increase to the initial porosity. We show that the “inlet” instability is likely to be important in limestone formations where the initial porosity is small and there is the possibility of a large increase in permeability. In quartz‐rich sandstones, where the proportion of easily soluble material (e.g., carbonate cements) is small, the instability in the steady‐state equations is dominant.
The Magnificent Seven: Close-by Cooling Neutron Stars?

We model Galactic populations of accreting and cooling isolated neutron stars in the attempt to explore their link with a new class of dim soft X-ray sources revealed by ROSAT. For accretors we follow the magneto-rotational and dynamical evolution in the Galactic potential and a realistic large scale distribution of the interstellar medium is used. Under standard assumptions old neutron stars enter the accretor stage only if their magnetic field exceeds $\approx 10^{11}$--$10^{12}$ G. We predict about 1 source per square degree for fluxes $\approx 10^{-15}$--$10^{-16}$ erg cm$^{-2}$s$^{-1}$ in the energy range 0.5-2 keV. Cooling neutron stars are explored within a simpler model of local sources, including however interstellar absorption. They are found to be significantly less abundant at low fluxes, $<0.1$ sources per square degree, but dominate over accretors at higher flux levels ($\approx 10^{-12}$--$10^{-11}$ erg cm$^{-2}$s$^{-1}$). We suggest that the faint sources observed by ROSAT may be young cooling neutron stars with typical age $\la 10^6$ yrs, if the total number of young neutron stars in the Solar proximity is $\sim 10$ times higher than inferred from radiopulsars statistics.
VIEW-FINDER : EUROPEAN PROJECT AIMING CRISIS MANAGEMENT TOOLS AND THE ROBOTICS ASSISTANCE TO FIRE-FIGHTING SERVICES

In the event of an emergency due to a fire or other crisis, a necessary but time consuming pre-requisite, that could delay the real rescue operation, is to establish whether the ground or area can be entered safely by human emergency workers. The objective of the VIEW-FINDER project is to develop robots which have the primary task of gathering data. The robots are equipped with sensors that detect the presence of chemicals and, in parallel, image data is collected and forwarded to an advanced Control station (COC). The robots will be equipped with a wide array of chemical sensors, on-board cameras, Laser and other sensors to enhance scene understanding and reconstruction. At the control station the data is processed and combined with geographical information originating from a web of sources; thus providing the personnel leading the operation with in-situ processed data that can improve decision making. The information may also be forwarded to other forces involved in the operation (e.g. fire fighters, rescue workers, police, etc.). The robots connect wirelessly to the control station. The control station collects in-situ data and combines it with information retrieved from the large-scale GMES-information bases. It will be equipped with a sophisticated human interface to display the processed information to the human operators and operation command. We’ll essentially focus in this paper to the steps entrusted to the RMA and PIAP through the work-packages of the project.
Tree-based conditional copula estimation

This paper proposes a regression tree procedure to estimate conditional copulas. The associated algorithm determines classes of observations based on covariate values and fits a simple parametric copula model on each class. The association parameter changes from one class to another, allowing for non-linearity in the dependence structure modeling. It also allows the definition of classes of observations on which the so-called"simplifying assumption"[see Derumigny and Fermanian, 2017] holds reasonably well. When considering observations belonging to a given class separately, the association parameter no longer depends on the covariates according to our model. In this paper, we derive asymptotic consistency results for the regression tree procedure and show that the proposed pruning methodology, that is the model selection techniques selecting the appropriate number of classes, is optimal in some sense. Simulations provide finite sample results and an analysis of data of cases of human influenza presents the practical behavior of the procedure.
Die präsuizidale Entwicklung zu einem assistierten Suizid

Zusammenfassung Drei Patienten mit neurologischen Krankheitsbildern und ihre Angehörigen wurden über Wochen bis Monate in der Vorbereitung eines assistierten Suizids begleitet, zwei bis zur Ausführung in der Schweiz und einer bis zum Tod durch eine interkurrente Erkrankung. Zahlreiche Gespräche ermöglichten einen Einblick in Entstehungsbedingungen, Begründungen und Motive. Insgesamt sieben Coping-Phasen wurden unterschieden, die Therapie-Hoffnung, die Verunsicherung, die Depression, die Konkretisierung, die spirituelle Reorientierung, die Gelöstheit sowie eine Nachverarbeitungsphase der Nahestehenden. Sie weisen variable Dauern, Überlappungen, Vorgriffe und »Flashback« sowie interpersonale Asynchronien auf. Zu einem besseren Verständnis hilft die Beachtung der Komplementarität von Bilanzund AppellAspekten und der Ambitendenzen der Patienten wie ihrer Umgebung. Formal ist die Entwicklung zu einem assistierten Suizid durch eine »Schwellensituation« absehbarer Verschlechterungen und eine »PrognoseSchere« mit abnehmender Selbstständigkeit bei kaum begrenzter Lebenserwartung gekennzeichnet. Dieser entspricht eine »Bewertungs-Schere« mit intellektueller Souveränität und als entscheidend erlebten Einbußen von Selbstwert, Autonomie und Würde. Darin zeigt sich eine Komplementarität von Unfreiheit und Freiheit (15) der geplanten Suizidentscheidung. In einer Begleitung, die eine behutsame personale Begegnung verwirklicht (13), kann dem Gehenden Geborgenheit und Trost vermittelt und erkennendes Reifen ermöglicht werden.
A Demonstration of DBWipes: Clean as You Query

As data analytics becomes mainstream, and the complexity of the underlying data and computation grows, it will be increasingly important to provide tools that help analysts understand the underlying reasons when they encounter errors in the result. While data provenance has been a large step in providing tools to help debug complex workflows, its current form has limited utility when debugging aggregation operators that compute a single output from a large collection of inputs. Traditional provenance will return the entire input collection, which has very low precision. In contrast, users are seeking precise descriptions of the inputs that caused the errors. We propose a Ranked Provenance System, which identifies subsets of inputs that influenced the output error, describes each subset with human readable predicates and orders them by contribution to the error. In this demonstration, we will present DBWipes, a novel data cleaning system that allows users to execute aggregate queries, and interactively detect, understand, and clean errors in the query results. Conference attendees will explore anomalies in campaign donations from the current US presidential election and in readings from a 54-node sensor deployment.
Power management techniques for mobile communication

In mobile computing, power is a hmited r=ouce. Like other devices, communication devices need to be prop erly managed to conserve energy. In this paper, we prment the design and implementation of an innovative trartspori level protocol capable of significantly reducing the power usage of the communication device. The protocol achieves power savings by selectively choosing short periods of time to suspend communications and shut down the communication device. It manages the important task of queuing data for future dehvery during periods of communication suspension, and decides when to restart communication. We *O address the tradeoff between reducing power consumption and reducing delay for incoming data. We present resdts from experiments using our implementation of the protocol. Th=e experiments measure the energy consumption for three simrdated communication patterns and compare the effects of different suspension strategies. Our r-tits show up to an 83~0 savings in the energy consumed by the communication. This can translate to a 6-9% savings in the energy consumed by an entire high end laptop or a savings of up to 40% for current hand-held PCs. The resdting delay introduced is sm~ (0.4-3.1 seconds depending on the power management level).
Ambulatory assessment of affective instability in borderline personality disorder: The effect of the sampling frequency.

Abstract. Affective instability is an essential criterion for borderline personality disorder (BPD) but studies using diaries have rendered conflicting results. Discrepant findings may be caused by differences in the time-based design, especially in the diverse length of the time intervals between self-reports. Even though there is consensus that the time-based design should fit the temporal dynamics of the processes of interest, no general conventions exist. We used 24 h ambulatory monitoring to repeatedly assess subjective ratings of distress in 50 BPD-patients and in 50 healthy controls. We investigated if the chosen time-based design with a time interval of 15 min between self-reports (1) reveals within subject variability in BPD-patients and (2) taps the process of interest. Using graphical and statistical evaluation, we demonstrate that the time-based design (15 min/24 h) does catch within-person variability in the BPD-patients. Comparison of the original data with randomly distributed data (simulat.
cisExpress: motif detection in DNA sequences

MOTIVATION One of the major challenges for contemporary bioinformatics is the analysis and accurate annotation of genomic datasets to enable extraction of useful information about the functional role of DNA sequences. This article describes a novel genome-wide statistical approach to the detection of specific DNA sequence motifs based on similarities between the promoters of similarly expressed genes. This new tool, cisExpress, is especially designed for use with large datasets, such as those generated by publicly accessible whole genome and transcriptome projects. cisExpress uses a task farming algorithm to exploit all available computational cores within a shared memory node. We demonstrate the robust nature and validity of the proposed method. It is applicable for use with a wide range of genomic databases for any species of interest. AVAILABILITY cisExpress is available at www.cisexpress. org.
Prospects for Applying the Social Relations Model to Person Perception

One of the most frustrating aspects of being a scientist is the lack of feedback. So often we have worked long and hard on a paper, and, after the paper is published, we never receive a letter or any real comment about it. We consider ourselves lucky if the paper receives an occasional citation from someone besides ourselves. For most of us to enjoy our work, we must rely on the intrinsic rewards of doing it. So I am extremely gratified that my book, Interpersonal Perception: A Social Relations Analysis, has received four reviews from a group of serious scholars. Many criticisms concern limitations that I have already addressed in the book's final chapter. This response more complements than criticizes the four reviews. My response is organized around whether the approach developed in my book will be applied by the next generation of researchers in person perception. First, background concerning the book's orientation to person perception is presented. Next considered is the potential integration of the approach within social cognition and reasons why researchers are reluctant to adopt the approach. Likely future research will be an investigation of moderators, and a preliminary discussion of these variables is presented. Also, the approach requires designs like round-robins. Because the need for such designs has been questioned, a defense of roundrobin designs is presented. Finally, a series of miscellaneous issues is reviewed.