Miracle-dz/UniFAR-FTUs huggingface dataset:
City Branding in Cyprus: From Theory to Development

This paper is concerned with the extent of implementation of city marketing and branding in Cyprus. In the effort to investigate this, a research was conducted in three major cities in Cyprus: Nicosia, Limassol, and Pafos. The approach of the research was to construct an interview with questions posed to key players in city development and management. The questions were formed via extrapolation from five hypotheses which were based on a collection of elements derived from an integrated city branding framework. The literature review is investigated, as well as matters involving city marketing as a part of urban governance. The relevant data is analysed and an evaluation of city marketing and branding theory, implementation in Cyprus is presented. The final conclusions are concerned with matters such as the lack of understanding for the need of city marketing by local authorities, the competitive behaviour of municipalities, the lack of communications with local communities, the schism between the private and public sectors and lack of synergies, and the limitations posed to local authorities by the current legal framework in Cyprus.
Debates—Stochastic subsurface hydrology from theory to practice: Why stochastic modeling has not yet permeated into practitioners?

We address modern topics of stochastic hydrogeology from their potential relevance to real modeling efforts at the field scale. While the topics of stochastic hydrogeology and numerical modeling have become routine in hydrogeological studies, nondeterministic models have not yet permeated into practitioners. We point out a number of limitations of stochastic modeling when applied to real applications and comment on the reasons why stochastic models fail to become an attractive alternative for practitioners. We specifically separate issues corresponding to flow, conservative transport, and reactive transport. The different topics addressed are emphasis on process modeling, need for upscaling parameters and governing equations, relevance of properly accounting for detailed geological architecture in hydrogeological modeling, and specific challenges of reactive transport. We end up by concluding that the main responsible for nondeterministic models having not yet permeated in industry can be fully attributed to researchers in stochastic hydrogeology.
Incidence of histoplasmosis in patients receiving TNF-alpha inhibitors: A systematic review and meta-analysis

Background: Immunobiological drugs such as TNF-α inhibitors are valuable in rescue therapy for autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease (IBD), but they increase the risk of infectious complications. Histoplasmosis is a significant concern in patients living in endemic regions, however, few studies have assessed the incidence of Histoplasma infection during therapy, and classic estimates may underestimate the risk. This study aimed to produce an updated risk estimate of histoplasmosis in patients on TNF-α blocking therapy. Methods: This is a systematic review and meta-analysis of studies that contain parameters for calculating the risk of histoplasmosis in people who use TNF-α inhibitors, to produce a risk estimate. Results: We identified 11 studies with the necessary parameters for inclusion in the meta-analysis, most of which were from North America. The incidence rate of histoplasmosis found was 33.52 cases per 100,000 patients treated with TNF-ɑ inhibitors (95% CI 12.28–91.46). Considering only studies evaluating monoclonal antibodies, the calculated incidence was 54.88/100,000 patients treated (95%CI 23.45–128.34). In subgroup analysis, the incidence was much higher in patients with IBD compared to rheumatic diseases. There was significant heterogeneity among the studies. Conclusion: The risk of histoplasmosis during TNF-α inhibitory therapy may be considerably higher than that found in classical estimates, especially in patients with IBD. There is a lack of studies evaluating histoplasmosis in large endemic areas, such as Central and South America.
Eastern redcedar roots create legacy effects that suppresses growth of prairie species

Abstract The expansion of woody species from their historical ranges into grasslands is a global problem. Understanding the mechanisms that enable species to successfully establish and then re‐encroach following their removal is critical to effectively managing problem species. Legacy effects are a mechanism that could be critical to the reestablishment of woody encroachers following their removal. Legacy effects occur when a species alters the biotic and abiotic environment in a way that affects communities that establish subsequently. In this study, we assess whether the eastern redcedar (Juniperus virginiana), a North American woody encroacher, generates legacy effects that affect communities that establish following removal of this species from an experimental grass community. We conducted a series of experiments to evaluate the effects of J. virginiana, roots on the germination and growth of grasses and to determine if the effects of root‐addition treatments were derived from a microbial or allelopathic origin. Aqueous extracts of J. virginiana roots were found to inhibit the germination of grasses. We found escalating suppression of overall community biomass and the biomass of each individual species with increasing root treatments. Finally, we determined the origin of the observed suppressive effect is unlikely to be of microbial origin. Synthesis: Our results suggest that J. virginiana exudes an allelochemical into soils that inhibits the growth of certain grasses and thus has the potential to have legacy effects on future occupants. We suggest that the inhibition of the development of grasses in areas where J. virginiana has been removed is a mechanism that may favor the reestablishment of J. virginiana. Our results indicate the legacy effects of J. virginiana must be considered when conducting removal and restoration of J. virginiana infested lands.
Midazolam for Anesthetic Premedication in Children: Considerations and Alternatives

Premedication in anesthesia has long been used to reduce patient anxiety, increase patient compliance, and supplement the overall anesthetic. In pediatric populations, premedication also has the indirect benefits of reducing parental anxiety as well as both the incidence and severity of emergence delirium. Oral midazolam, selected for its ease of administration, short duration of action, and reliable anxiolytic and amnestic effects, has been a favorite choice in this role for decades. The side effect profile of midazolam is also relatively benign, heavily dose-dependent, and easily managed in the perioperative setting. While midazolam appears to be an ideal adjunct in the anesthetic care of pediatric patients, there is a growing body of evidence suggesting prolonged benzodiazepine exposure causes neurodevelopmental changes in infants. This evidence, along with the 2017 Food and Drug Administration (FDA) warning labels for the use of select anesthetic medications, including midazolam in children under the age of three, has led to some debate in the anesthetic community over the continued use of this anesthetic for premedication in pediatric populations. This article aims to educate the reader on the history of midazolam as a premedication agent in pediatric populations and examine the evidence supporting and against its continued use in this role.
Implementation of holistic nursing interventions based on fast track surgery concept in patients with lower extremity arterial occlusive disease

Lower Extremity Arterial Occlusive Disease (LEAOD) is a prevalent condition affecting many patients worldwide, which requires careful management and patient cooperation. This study aimed to evaluate the effectiveness of holistic nursing interventions based on the Fast Track Surgery (FTS) concept in patients with LEAOD. A retrospective analysis of 92 LEAOD patients, randomized into control and experimental groups, was performed. Conventional rehabilitation nursing interventions were applied to the control group, while the experimental group received holistic rehabilitation nursing interventions based on the FTS concept. Patient adherence was assessed before and after the intervention using a hospital survey, and sleep quality was evaluated using the Pittsburgh Sleep Quality Index on days 3, 7, and 15 post-interventions. Post-intervention, the experimental group exhibited significantly improved adherence to balanced diet, regular exercise, timely medication, and regular review visits compared to the control group (P < .05). Further, Pittsburgh Sleep Quality Index scores indicated significantly better sleep quality over time in the experimental group than in the control group (P < .05). The implementation of holistic nursing interventions based on the FTS concept significantly improved patient adherence and sleep quality in LEAOD patients. These findings highlight the potential benefits of integrating such interventions in the management of LEAOD patients, potentially enhancing postoperative recovery and overall health outcomes.
Extracellular vesicles and co‐isolated endogenous retroviruses from murine cancer cells differentially affect dendritic cells

Cells secrete extracellular vesicles (EVs) and non‐vesicular extracellular (nano)particles (NVEPs or ENPs) that may play a role in intercellular communication. Tumor‐derived EVs have been proposed to induce immune priming of antigen presenting cells or to be immuno‐suppressive agents. We suspect that such disparate functions are due to variable compositions in EV subtypes and ENPs. We aimed to characterize the array of secreted EVs and ENPs of murine tumor cell lines. Unexpectedly, we identified virus‐like particles (VLPs) from endogenous murine leukemia virus in preparations of EVs produced by many tumor cells. We established a protocol to separate small EVs from VLPs and ENPs. We compared their protein composition and analyzed their functional interaction with target dendritic cells. ENPs were poorly captured and did not affect dendritic cells. Small EVs specifically induced dendritic cell death. A mixed large/dense EV/VLP preparation was most efficient to induce dendritic cell maturation and antigen presentation. Our results call for systematic re‐evaluation of the respective proportions and functions of non‐viral EVs and VLPs produced by murine tumors and their contribution to tumor progression.
Assessing multiple factors affecting the gut microbiome structure of very preterm infants

The composition and diversity of the gut microbiota are essential for the health and development of the immune system of infants. However, there is limited information on factors that influence the gut microbiota of very preterm infants. In this study, we analyzed factors that affect the gut microbiota of very preterm infants. The stool samples from 64 very preterm infants with a gestational age less than 32 weeks were collected for 16S rRNA gene sequencing. The infants were divided according to the delivery mode, antibiotic use during pregnancy, and feeding methods. The abundance of Proteobacteria was high in both cesarean (92.7%) and spontaneous (55.5%) delivery groups and then shifted to Firmicutes after the first week of birth. In addition, Proteobacteria was also the dominant phylum of infant gut microbiome for mothers with antibiotic use, with more than 50% after the first week of birth. In comparison, the dominant phylum for mothers without antibiotic use was Firmicutes. Proteobacteria level was also high in breastfeeding and mixed-feeding groups, consisting of more than 90% of the community. By contrast, Proteobacteria was the dominant phylum at the first week of birth but then shifted to Firmicutes for the formula-fed group. The alterations of gut microbiota in infants can affect their health condition during growth. This study confirmed that the different feeding types, delivery modes, and use of antibiotics during pregnancy can significantly affect the composition of the gut microbiota of very preterm infants.
circRARS synergises with IGF2BP3 to regulate RNA methylation recognition to promote tumour progression in renal cell carcinoma

Abstract As the most prominent RNA modification, N6‐methyladenosine (m6A) participates in the regulation of tumour initiation and progression. Circular RNAs (circRNAs) also play crucial roles in ubiquitous life processes. Whether circRNAs are required for m6A regulation in renal cell carcinoma (RCC) remains unclear. Meta‐analysis and bioinformatics identified that IGF2BP3 was upregulated in RCC and indicated a worse prognosis. IGF2BP3 significantly promoted RCC progression in vitro and in vivo. Mechanistically, circRARS bound to KH1–KH2 domains of IGF2BP3 to enhance m6A modification recognition. A 12‐nt sequence (GUCUUCCAGCAA) was proven to be the IGF2BP3‐binding site of circRARS. Additionally, CAPN15, CD44, HMGA2, TNRC6A and ZMIZ2 were screened to be the target genes regulated by the IGF2BP3/circRARS complex in an m6A‐dependent manner. Stabiliser proteins, including HuR, Matrin3 and pAbPC1, were recruited by circRARS, thereby increasing the mRNA stability of the forementioned five target genes. Consequently, the IGF2BP3/circRARS complex facilitated the lipid accumulation of RCC cells and promoted sunitinib resistance via target genes. circRARS synergised with IGF2BP3 to facilitate m6A recognition, thereby promoting RCC progression. Thus, IGF2BP3 could be a potential biomarker for RCC diagnosis and prognosis and a therapeutic target.
The “heterogeneous” effect of government grants on bank lending

This study aims to test whether banks can recognize different signals from different types of government grants received by their clients and respond differently. Using a novel panel data set from China, we construct a three-way fixed-effect regression model and empirically explore the effect of government grants received by banks’ clients on banks’ lending decisions. We find that banks have heterogeneous attitudes towards their clients when the clients receive different types of government grants. In particular, we discover that banks behave positively toward clients who receive "development supportive" grants but negatively toward clients who receive "helping hand" grants. The main results hold after a series of robustness tests. Our study offers fresh perceptions on how banks see government grants of their clients while making lending choices. Our finds will offer certain inspirations for government grant policies and bank lending decisions.
Approaches to continental intraplate earthquake issues

The papers in this volume illustrate a number of approaches that are becoming increasingly common and offer the prospect of making signifi cant advances in the broad related topics of the science, hazard, and policy issues of large continental intraplate earthquakes. Plate tectonics offers little direct insight into the earthquakes beyond the fact that they are consequences of slow deformation within plates and, hence, relatively rare. To alleviate these problems, we use space geodesy to defi ne the slowly deforming interiors of plates away from their boundaries, quantify the associated deformation, and assess its possible causes. For eastern North America, by far the strongest signal is vertical motion due to ice-mass unloading following the last glaciation. Surprisingly, the expected intraplate deformation due to regional stresses from plate driving forces or local stresses are not obvious in the data. Several approaches address diffi culties arising from the short history of instrumental seismology compared to the time between major earthquakes, which can bias our views of seismic hazard and earthquake recurrence by focusing attention on presently active features. Comparisons of earthquakes from different areas illustrate cases where earthquakes occur in similar tectonic environments, increasing the data available. Integration of geodetic, seismological, historical, paleoseismic, and other geologic data provides insight into earthquake recurrence and the diffi cult question of why the earthquakes are where they are. Although most earthquakes can be related to structural features, this explanation alone has little predictive value because continents contain many such features, of which a few are the most active. It appears that continental intraplate earthquakes are episodic, clustered, and migrate. Thus on short time scales seismicity continues on structures that are active at present, perhaps in part because many events are aftershocks of larger past events. However after periods of activity these structures may become inactive for a long time, so the locus of at least some of the seismicity migrates to other structures. Analysis of the thermo-mechanical structure of the seismic zones gives insight into their mechanics: whether there is something special about them that results in long-lived weak zones on which intraplate strain release concentrates, or as seems more likely, that they are not that unusual, so seismicity migrates. Accepting our lack of understanding of the underlying causes of E-mail: seth@earth.northwestern. edu. 2 Stein spe425-01 page 2
Sanji Peiyuan decoction combined with dydrogesterone in the treatment of massive subchorionic hematoma: A case report

Rationale: Subchorionic Hematoma, often referred to as Bruce hematoma, can lead to serious obstetric complications such as intrauterine growth restriction and fetal death, as well as early and late pregnancy miscarriage, placental abruption, and premature rupture of membranes, posing great harm to both mother and fetus. Patient concerns: At present, Western medical treatments have not shown satisfactory results, necessitating the discovery of more effective clinical treatment methods. Diagnoses: Threatened miscarriage, Subchorionic hematoma, Iron deficiency anemia (mild). Interventions: Sanji Peiyuan decoction combined with dydrogesterone. Outcomes: Following 17 days of treatment with Sanji Peiyuan decoction and oral dydrogesterone tablets, the hematoma was no longer detectable by ultrasound. The patient experienced no symptoms such as abdominal pain, bloating, or vaginal bleeding. She successfully gave birth around her due date, with both the mother and child in good health. Lessons: The combination of Sanji Peiyuan decoction and oral dydrogesterone tablets shows promising clinical efficacy in treating Massive Subchorionic Hematomas. This method merits further clinical research.
Inhaled Medication Errors During Hospitalization or on Hospital Discharge in Patients Living With Chronic Obstructive Pulmonary Disease: A Literature Review

Inhaled medications, including beta-agonists, muscarinic antagonists, and corticosteroids, are the backbone of chronic obstructive pulmonary disease (COPD) treatment, and pharmacotherapy plans are frequently optimized during and following hospitalization. Clinical practice guidelines acknowledge that patients living with COPD may experience medication errors from inadequate inhaler technique or device faults, but inhaled medication errors within COPD pharmacotherapy plans remain unreported. This literature review aimed to collect and present studies describing medication errors occurring with inhaled medications in patients living with COPD during and following hospitalization. The databases searched included Ovid MEDLINE, Embase, and International Pharmaceutical Abstracts. One hundred forty-five unique studies were collected, and 10 studies were included. The rate of inhaled medication errors reported across the 10 studies ranged between 2.5% and 66% of patients living with COPD and who were hospitalized or discharged. The incidence and types of medication errors reported across the studies varied significantly. Standardization in categorizing and reporting inhaled medication errors is necessary for future studies to determine the true incidence of inhaled medication errors occurring in patients living with COPD who are hospitalized or discharged.
as a barrier to Pacific-Atlantic through flow Cenozoic tectonic history of the South Georgia microcontinent and potential

Cenozoic opening of the central Scotia Sea involved the tectonic translation of crustal blocks to form the North Scotia Ridge, which today is a major topographic constriction to the fl ow of the deep Antarctic Circumpolar Current that keeps Antarctica thermally isolated from warmer ocean waters. How this ridge developed and whether it was a topographic barrier in the past are unknown. To address this we investigated the Cenozoic history of the South Georgia microcontinental block, the exposed part of the ridge. Detrital zircon U-Pb geochronology data confi rm that the Cretaceous succession of turbidites exposed on South Georgia was stratigraphically connected to the Rocas Verdes backarc basin, part of the South America plate. Apatite thermochronometry results show that South Georgia had remained connected to South America until ca. 45–40 Ma; both record a distinct rapid cooling event at that time. Subsequent separation from South America was accompanied by kilometer-scale reburial until inversion ca. 10 Ma, coeval with the cessation of spreading at the West Scotia Ridge and collision between the South Georgia block and the Northeast Georgia Rise. Our results show that the South Georgia microcontinental block could not have been an emergent feature from ca. 40 Ma until 10 Ma. GEOLOGY, April 2014; v. 42; no. 4; p. 299–302; Data Repository item 2014112 | doi:10.1130/G35091.1 | Published online 10 February 2014 © 2014 eological Society of America. Gold Open Access: This paper is published under the terms of the CC-BY license. 75°W 65°W 55°W 45°W 35°W 25°W
Association between physical activity levels and anxiety or depression among college students in China during the COVID-19 pandemic: A meta-analysis

Background: This meta-analysis aimed to investigate the links between the level of physical activity and the risk of anxiety or depression among college students in China during the Coronavirus Disease 2019 pandemic. Methods: Eligible studies were searched from the PubMed, Embase, and Web of Science databases. The associations between them were assessed with odd ratio (OR) and 95% confidence interval (CI). The heterogeneity of the included studies was evaluated and subgroup analysis was performed. Sensitivity analysis was executed using leave-one-out method. Publication bias of included studies was evaluated. Ten studies with moderate quality were included. Results: Physical activity levels of college students were associated with reduced risk of depression (OR [95%CI] = 0.69 [0.58, 0.82], P < .001) and anxiety (OR [95%CI] = 0.71 [0.62, 0.80], P < .001). The measurement scale of depression or anxiety and whether multi-factor correction was performed or not did not influence the pooled results. The pooled results of depression and anxiety were stable and were not significantly influenced by a single study. No publication bias was observed in the included studies reporting depression and anxiety. Conclusion: The physical activity level of college students is negatively correlated with anxiety and depression in China during the pandemic. During the Coronavirus Disease 2019 pandemic, it is necessary to strengthen the construction of university physical education courses. As an organized form of physical activity, physical education classes are a necessary and effective way to increase physical activity among college students.