Miracle-dz/UniFAR-FTUs huggingface dataset:
Ecopsychology's Niche: Why the Transpersonal Matters to Ecopsychology

I appreciate the Editor’s broad invitation to ecopsychologists to comment on the current state of this field and to suggest future directions. While there are a number of valid responses in this discussion, I feel the field’s greatest need is to continue to clarify and articulate its core principles and then hold close to them. Ecopsychology shares a close affinity, some concepts and narratives, research findings, and a deep concern for the fate of the world with several other fields. However, if we do not continue to articulate and embody ecopsychology’s particular view, this field will be sidelined. One of ecopsychology’s most important tasks is to find and fill its particular niche. Environmental psychology, conservation psychology, deep ecology, and many other related fields already do a good job of filling certain niches. We as ecopsychologists do not need to duplicate their contributions, important as they are. At the same time, there are certain tasks, questions, and understandings that ecopsychology is uniquely able to address. I believe greater clarity about ecopsychology’s foundations will reveal this niche. I have a particular interest in one of these foundations.
Ca2+ sparks triggered by patch depolarization in rat heart cells.

The goal of this study was to examine the relationship between Ca2+ entry through L-type Ca2+ channels and local [Ca2+]i transients (Ca2+ sparks) in single rat cardiac ventricular cells. L-type Ca2+ channels were activated by depolarization of cell-attached membrane patches, and [Ca2+]i was measured simultaneously as fluo 3 fluorescence using laser scanning confocal microscopy. Patch depolarization with Ca2+ as the charge carrier (10 or 110 mmol.L(-1)) significantly increased the probability of the occurrence of Ca2+ sparks (Ca2+ spark rate) only in the volume of cytoplasm located immediately beneath the membrane patch (basal Ca2+ spark rate, 119 Ca2+ sparks.cell(-1). s(-1); patch depolarization Ca2+ spark rate, 610 Ca2+ sparks.cell(-1). s(-1); P<. 005). With Ba2+ in the pipette solution (10 mmol.L(-1)), patch depolarization was not associated with an increased Ca2+ spark rate at the position of the pipette or at any other sites distant from the pipette. Therefore, Ca2+ entry and not voltage per se was a necessary event for the occurrence of Ca2+ sparks. Under identical experimental conditions, patch depolarization experiments opened single L-type Ca2+ channels with a single-channel conductance of 19 pS with Ba2+ as the charge carrier. Although single-channel openings could not be resolved when Ca2+ was the charge carrier, ensemble averages yielded an inward current of up to 0.75 pA. The results suggest that voltage-activated Ca2+ entry through one or a small number of L type Ca2+ channels triggers the release of Ca2+ only from the sarcoplasmic reticulum in direct proximity to those L-type Ca2+ channels. The relatively low probability of triggering Ca2+ sparks may have resulted from some alteration of excitation-contraction coupling associated with the technique of the cell-attached patch clamp.
Mating and Memory

The literature on sexual selection and the social brain hypothesis suggest that human cognition and communication evolved, in part, for the purpose of displaying desirable cognitive abilities to potential mates. An evolutionary approach to social cognition implies that proximate mating motives may lead people to display desirable mental traits. In signaling such traits, one can increase the likelihood of attracting a potential mate. Two experiments demonstrated that exposure to mating cues—highly attractive opposite-sex faces—led people to display enhancements in declarative memory—a process underlying a variety of abilities such as resource acquisition, intelligence, and creativity. Experiment 1 showed that men (but not women) displayed enhanced memory for details of a story that was presented during exposure to highly attractive opposite-sex faces. Experiment 2 demonstrated that heightened displays of declarative memory reflect an enhancement in retrieval rather than in encoding. Findings contribute to the literatures on human mating and cognitive performance and provide novel insight into links between social processes and basic cognition.
Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus

Toll-like receptors (TLRs) are a large family of pattern recognition receptors. TLR signals are involved in the pathogenesis of systemic lupus erythematosus. Mouse and human B cells constitutively express most TLRs. Many B cell subpopulations are highly responsive to certain TLR ligation, including B-1 B cells, transitional B cells, marginal zone B cells, germinal center B cell and memory B cells. The B cell-intrinsic TLR signals play critical roles during lupus process. In this review, roles of B cell-intrinsic TLR2, 4, 7, 8 and 9 signals are discussed during lupus pathogenesis in both mouse model and patients. Moreover, mechanisms underlying TLR ligation-triggered B cell activation and signaling pathways are highlighted.
Stress ocupacional em profissionais de saúde: um estudo com médicos e enfermeiros portugueses

Occupational stress in health professionals: a study with portuguese doctor’s and nurse practitioners. This work analyzes occupational stress in 155 health professionals (example: doctors and nurses) from hospitals and health care centres in the north of Portugal. We evaluated the following variables: stress, burnout, proactive coping, organizational commitment and satisfaction/professional fulfilment. Results revealed significant stress experiences in 15% of the professionals and emotional exhaustion problems in 6%. Comparative analysis (MANOVA and t-test for independent samples) suggested a higher tendency to experience occupational stress in the following groups: a) females (although males showed more depersonalization problems); b) younger and less experienced professionals; c) single persons; d) nurses practitioners; e) professionals that worked in health care centres; f) those professionals with short-term working contracts; and g) the professionals working on a shift-basis system. At the end, we discuss some of the implications for future research of the present study.
Does a Uniform Retirement Age Make Sense

In the face of rising life expectancies, many policy experts argue that today’s workers can retire later and still spend the same fraction of their lives in retire­ment as past generations. But such an argument assumes that all workers, regardless of socioeconomic status (SES), have experienced the same increase in life expectancy. In fact, evidence suggests that life expectancies for low-SES individuals have been improving more slowly than for high-SES individuals in recent decades, causing the life expectancy gap to grow. This brief, based on a recent study, builds on prior research by estimating trends in mortality (the flip side of life expectancy) from 1979-2011 by education, a common measure of SES. These estimates are then used to see how much longer each educational group can work today if the goal is to maintain the same ratio of retirement years to working years as existed in 1979. The discussion is organized as follows. The first section describes the data and methodology used in the analysis. The second section presents the results. The final section concludes that, due to growing mor­tality inequality, policies aimed at extending worklives uniformly may not be fair to low-SES individuals.
Headache and neck pain in spontaneous internal carotid and vertebral artery dissections

We studied the characteristics of headaches in 161 consecutive symptomatic patients with spontaneous dissections of the internal carotid artery (n equals 135) or the vertebral artery (n equals 26). For patients with internal carotid artery dissection (ICAD), the mean age was 47 years and for those with vertebral artery dissection (VAD), 40.7 years. A history of migraine was present in 18% of the ICAD group and in 23% of the VAD group. Headache was reported by 68% of the patients with ICAD and by 69% of those with VAD, and, when present, it was the initial manifestation in 47% of those with ICAD and in 33% of those with VAD. Ten percent of patients with ICAD had eye, facial, or ear pain without headache. The median interval from onset of headache to development of other neurologic manifestations was 4 days for the ICAD group and 14.5 hours for the VAD group. For all dissections, headaches typically were ipsilateral to the side of dissection. In the ICAD group, headaches were limited to the anterior head in 60% of patients and were steady in 73% and pulsating in 25%. In the VAD group, headaches were distributed posteriorly in 83% of patients and were steady in 56% and pulsating in 44%. Neck pain was present in 26% of patients with ICAD (anterolateral) and in 46% of those with VAD (posterior). The median duration of the headache in patients with VAD and ICAD was 72 hours, but headaches became prolonged, persisting for months to years, in four patients with ICAD. NEUROLOGY 1995;45: 1517-1522
Worries and values.

Relations of individuals' value priorities to their worries are investigated in seven samples from four cultural groups (N = 1,441). A social-cognitive analysis suggests that value priorities influence worries by increasing attention to and perception of threats to valued goals. On this basis, we generate hypotheses relating two types of worries, micro (about self and its extensions) and macro (about society and world), to 10 types of values. As predicted, giving priority to self-transcendence values (universalism and benevolence) is associated with low micro and high macro worry, whereas giving priority to self-enhancement values (power, hedonism, and--to a lesser degree--achievement) is associated with high micro and low macro worry. Meaningful associations are also found for other values. Values account for substantially more variance in macro than in micro worries.
Enhancing Entrepreneurship Education Through Memletic Learning Theory

This paper describes the role of Memletic learning style theory in the curriculum design of an undergraduate entrepreneurship course. The seven Memletic categories classify learning propensities based upon the theory of multiple intelligences whereby substructures to individual’s intelligences may be identified, providing insight into behavior and learning preferences. Activities, assignments and teaching strategies in this highly experiential course were designed to address each learning style preference. This paper illustrates a curriculum design strategy that encourages the development of entrepreneurial orientation and behaviors by applying Memletic learning style theory. Detailed class exercises, term projects, and imagination development tools are highlighted.
A novel mice model of metabolic syndrome: the high-fat-high-fructose diet-fed ICR mice

Currently, the metabolic syndrome (MS) is occurring at growing rates worldwide, raising extensive concerns on the mechanisms and therapeutic interventions for this disorder. Herein, we described a novel method of establishing MS model in rodents. Male Institute of Cancer Research (ICR) mice were fed with high-fat-high-fructose (HFHF) diet or normal chow (NC) respectively for 12 weeks. Metabolic phenotypes were assessed by glucose tolerance test, insulin tolerance test and hyperinsulinemic-euglycemic clamp. Blood pressure was measured by a tail-cuff system. At the end of the experiment, mice were sacrificed, and blood and tissues were harvested for subsequent analysis. Serum insulin levels were measured by ELISA, and lipid profiles were determined biochemically. The HFHF diet-fed ICR mice exhibited obvious characteristics of the components of MS, including obvious obesity, severe insulin resistance, hyperinsulinemia, dislipidemia, significant hypertension and hyperuricemia. Our data suggest that HFHF diet-fed ICR mice may be a robust and efficient animal model that could well mimic the basic pathogenesis of human MS.
Paraspeckle Protein 1 (PSPC1) Is Involved in the Cisplatin Induced DNA Damage Response—Role in G1/S Checkpoint

Paraspeckle protein 1 (PSPC1) was first identified as a structural protein of the subnuclear structure termed paraspeckle. However, the exact physiological functions of PSPC1 are still largely unknown. Previously, using a proteomic approach, we have shown that exposure to cisplatin can induce PSPC1 expression in HeLa cells, indicating the possible involvement for PSPC1 in the DNA damage response (DDR). In the current study, the role of PSPC1 in DDR was examined. First, it was found that cisplatin treatment could indeed induce the expression of PSPC1 protein. Abolishing PSPC1 expression by siRNA significantly inhibited cell growth, caused spontaneous cell death, and increased DNA damage. However, PSPC1 did not co-localize with γH2AX, 53BP1, or Rad51, indicating no direct involvement in DNA repair pathways mediated by these molecules. Interestingly, knockdown of PSPC1 disrupted the normal cell cycle distribution, with more cells entering the G2/M phase. Furthermore, while cisplatin induced G1/S arrest in HeLa cells, knockdown of PSPC1 caused cells to escape the G1/S checkpoint and enter mitosis, and resulted in more cell death. Taken together, these observations indicate a new role for PSPC1 in maintaining genome integrity during the DDR, particularly in the G1/S checkpoint.
Cancer and Dna Instability in Fra16d Chromosomal Fragile Site Updated Version Cited Articles Citing Articles E-mail Alerts Chromosomal Fragile Site Fra16d and Dna Instability in Cancer 1

It has been proposed that common aphidicolin-inducible fragile sites, in general, predispose to specific chromosomal breakage associated with deletion, amplification, and/or translocation in certain forms of cancer. Although this appears to be the case for the fragile site FRA3B and may be the case for FRA7G, it is not yet clear whether this association is a general property of this class of fragile site. The major aim of the present study was to determine whether the FRA16D chromosomal fragile site locus has a role to play in predisposing DNA sequences within and adjacent to the fragile site to DNA instability (such as deletion or trans-location), which could lead to or be associated with neoplasia. We report the localization of FRA16D within a contig of cloned DNA and demonstrate that this fragile site coincides with a region of homozygous deletion in a gastric adenocarcinoma cell line and is bracketed by translocation FRA3B and FRA7G fragile sites, it is likely that common aphidicolin-inducible fragile sites exhibit the general property of localized DNA instability in cancer cells.
OPEN ARCHITECTURE FOR EMBEDDING VR BASED MECHANICAL TOOLS IN CAD

By Hrishikesh S Joshi, M.S. Washington State University December 2006 Chair: Sankar Jayaram Virtual assembly technology is revolutionizing the way we design mechanical assemblies. This technology enables the users to interact with virtual models of mechanical assemblies in an immersive environment. The user interacts with the virtual environment via various hardware devices, which can track motion and other user inputs. These devices Haptic devices are also capable of providing touch and force feedback to the user. The existing virtual assembly systems however are not tightly integrated with the CAD systems that are primarily used for modeling the assemblies. This disconnect between the CAD systems and virtual reality (VR) environments is one of the most important limitation in the existing virtual assembly systems. In this thesis we propose an open architecture for embedding VR based virtual mechanical tools in the CAD systems. The goal of this research is to enhance the CAD experience by allowing the user to interact with the CAD assemblies inside a virtual environment in a more realistic manner. The open architecture is designed to leverage off of the inherent visualization capabilities provided by any commercial CAD system. The architecture consists of a CAD plugin module, which is primarily responsible for interacting with the CAD system and handling the visualization through the application programming interface (API) exposed by
Cognitive dysfunction in early-onset multiple sclerosis: a reappraisal after 10 years.

OBJECTIVE To reassess, in a cohort of patients with early-onset multiple sclerosis, the long-term evolution of cognitive deficits, their relationship to the disease's clinical progression, and their effects on daily life. DESIGN Ten years after our baseline assessment, we again compared the cognitive performance of patients and control subjects on a neuropsychological test battery. Clinical and demographic correlates of cognitive impairment and their effects on everyday functioning were determined by multiple linear regression analysis. SETTING The research clinic of a university department of neurology. PARTICIPANTS Forty-five inpatients and outpatients with multiple sclerosis and 65 demographically matched healthy controls from the original sample. MAIN OUTCOME MEASURES Mean scores of both groups on the neuropsychological test battery in initial and 2 follow-up evaluations (about 4 and 10 years, respectively); number of cognitively impaired subjects, defined by the number of subtests failed; regression coefficients measuring the relationship between clinical variables and cognitive outcome and between mental decline and everyday functioning assessed by the Environmental and the Incapacity Status Scales. RESULTS Previously detected cognitive defects in verbal memory, abstract reasoning, and linguistic processes were confirmed on the third testing, at which time deficits in attention/short-term spatial memory also emerged. Only 20 of 37 patients who were cognitively unimpaired on initial testing remained so by the end of the follow-up, when the proportion of subjects who were cognitively impaired reached 56%. Degree of physical disability, progressive disease course, and increasing age predicted the extent of cognitive decline. Disability level and degree of cognitive impairment were independent predictors of a patient's handicap in the workplace and in social settings. CONCLUSIONS In the course of a sufficiently long follow-up, cognitive dysfunction is likely to emerge and progress in a sizable proportion of patients. As multiple sclerosis advances, neurological and cognitive involvement tend to converge. Limitations in a patient's work and social activities are correlated with the extent of cognitive decline, independent of degree of physical disability.
TMR and Partial Dynamic Reconfiguration to mitigate SEU faults in FPGAs

This paper presents the adoption of the triple modular redundancy coupled with the partial dynamic reconfiguration of field programmable gate arrays to mitigate the effects of soft errors in such class of device platforms. We propose an exploration of the design space with respect to several parameters (e.g., area and recovery time) in order to select the most convenient way to apply this technique to the device under consideration. The application to a case study is presented and used to exemplify the proposed approach.
The use of talk-show video as a reflective practice to improve students’ vocabulary in english speaking skill (A Classroom Action Research at the Second Semester of English Education Department of IKIP PGRI Pontianak 2013/2014)

This thesis is written to 1) identity whether and to what extent talk show video improves students‟ vocabulary in speaking skill and 2) describe classroom climate when talk show video is applied in the speaking class. The method used in this research was classroom action research. The research was conducted in two cycles from Mei 30th until July 10th at the second semester of English Education Department of IKIP PGRI Pontianak 2013/2014. The research data were collected by using techniques of qualitative and quantitative data collection which includes; observation, questionnaire, journal or diaries, document analysis and test. The qualitative data were analyzed through constant comparative method and the statistic data were analyzed through T-test by calculated the students‟ score calculation, mean sore of pre-test and post-test. The research findings showed that talk show video in teaching and learning English could improve the students‟ vocabulary in speaking skill and the classroom climate. The improvement of students‟ vocabulary in speaking skill showed: (1) most of students pronounced the English words correctly; (2) most of students knew the meaning of English words, (3) most of students could use the words in sentence correctly according to the text. The improvement of classroom climate category showed dealing with a low of the students‟ speaking skill are: (1) the students were not noisy in the teaching learning process, they paid attention toward lesson and (2) the students encourage to use English in teaching learning speaking, by recording the talk show and let the students watch what they have done will reflect their by themselves, they will encourage themselves to get to know more about their vocabulary that related to the topic presented. Video will stimulate and motivate students‟ interesting in improving their vocabulary in speaking class. Beside the improvement of the students‟ score, the students did some activities who did not they do before using talk show video; (1) they did various activities during teaching learning using talk show video, (2) they could interact with their friends and collaborate with them during teaching learning speaking, and (3) they could be responsible to their jobs. As a result, talk show video is suitable for supporting and improving students‟ speaking skill, it has important role in teaching and learning process. Keywords: Talk show video, reflective practice, vocabulary, speaking skill, Class Action Research.
Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance.

Avia Herschkovitz, Yan-Fang Liu, Erez Ilan, Denise Ronen, Sigalit Boura-Halfon, and Yehiel Zick This article has been withdrawn by Erez Ilan, Sigalit Boura-Halfon, andYehiel Zick. Thewithdrawing authors have become aware of several errors in the way images were presented in thismanuscript. Because the original data are no longer available, the authors wish to withdraw the article in the interests of maintaining their publication standards and those of the journal. Lanes 3–6 of the IRS-1 immunoblot in Fig. 3A was reused in lanes 2–5 of the IRS-1 immunoblot in Fig. 3B. Fig. 7, A and B, was inappropriately manipulated. The withdrawing authors state that these presentational errors do not impact the underlying scientific findings of the article, which are also presented as quantitative line/bar graphs that essentially summarize data of a number of experiments. Therefore, the withdrawing authors stand by the original scientific results as described, which in the authors’ opinion has been confirmed in other laboratories (Zhang, J., Gao, Z., Yin, J., Quon, M. J., and Ye, J. (2008) S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-signaling through IKK2. J. Biol. Chem. 283, 35375–35382 and Hançer, N. J., Qiu,W. , Cherella, C. , Li, Y. , Copps, K. D. , andWhite, M. F. (2014) Insulin andmetabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation. J. Biol. Chem. 289, 12467–12484). WITHDRAWALS/RETRACTIONS