Miracle-dz/UniFAR-FTUs huggingface dataset:
Treatment of Resectable Gastric Cancer : An Update on the Role of Radiation and Chemotherapy

The operative and perioperative management of gastric cancer has been an area of controversy and ongoing study in both Eastern and Western patient populations. The extent of lymphadenectomy varies across regions. Various combinations of chemotherapy and radiation in the neoadjuvant and adjuvant setting have been studied in large randomized controlled trials. In the West, two major trials, the Medical Research Council Adjuvant Gastric Infusional Chemotherapy (MAGIC) trial and the SWOG/INT 0116 trial by Macdonald et al. have influenced perioperative therapy, but the efficacy of one versus the other has not yet been determined. Newer studies, such as the CRITICS trial, are investigating the potential benefits of neoadjuvant therapy in combination with adjuvant chemoradiation. This review describes the ongoing controversies in gastric cancer multimodal management and encompasses the evidence to date supporting current practices in the West. Sarwat Ahmad* and Nader Hanna Department of Surgery, University of Maryland School of Medicine, USA
First Case of Foot Drop Associated with Capecitabine in a Patient with Thymidylate Synthase Polymorphism

Capecitabine, an oral prodrug of 5-FU, has been approved by the FDA for use in patients with breast and colon cancers. In addition, capecitabine is commonly used in patients with other malignancies such as pancreatic, gastroesophageal, and hepatobiliary tract cancers. Though cerebellar toxicity is a rare but well-known side effect of intravenous 5-FU therapy, peripheral neuropathy with capecitabine has only been described in rare cases. In this case report, we describe a 79-year-old patient with locally advanced adenocarcinoma of the pancreas undergoing chemoradiation therapy with capecitabine who developed peripheral sensorimotor neuropathy. To the best of our knowledge, this is the first patient in the literature who was found to have two mutations (2R) of a 28 base-pair tandem repeat in the 5’ promoter enhancer region (5’-TSER) on both alleles (2R/2R) of thymidylate synthetase (TYMS) gene, possibly responsible for the neurotoxicity.
Detecting abnormal regions in colonoscopic images by patch-based classifier ensemble

In this paper, a new method is proposed to detect abnormal regions in colonoscopic images by patch-based classifier ensemble. Through supervised learning from image patches of various sizes, a set of basic SVM classifiers is trained for each size. A diagnostic model can then be constructed based on the ensemble of basic classifiers which is then used to detect abnormal regions in colonoscopic images. The multiple sizes of patches provide multiple level representation of the image content, which can help improve detection results. Several fusion criteria are explored to determine the final output of the ensemble. Experimental results show promising performance of our proposed method.
Secure hierarchy-aware cache replacement policy (SHARP): Defending against cache-based side channel attacks

In cache-based side channel attacks, a spy that shares a cache with a victim probes cache locations to extract information on the victim's access patterns. For example, in evict+reload, the spy repeatedly evicts and then reloads a probe address, checking if the victim has accessed the address in between the two operations. While there are many proposals to combat these cache attacks, they all have limitations: they either hurt performance, require programmer intervention, or can only defend against some types of attacks. This paper makes the following observation for an environment with an inclusive cache hierarchy: when the spy evicts the probe address from the shared cache, the address will also be evicted from the private cache of the victim process, creating an inclusion victim. Consequently, to disable cache attacks, this paper proposes to alter the line replacement algorithm of the shared cache, to prevent a process from creating inclusion victims in the caches of cores running other processes. By enforcing this rule, the spy cannot evict the probe address from the shared cache and, hence, cannot glimpse any information on the victim's access patterns. We call our proposal SHARP (Secure Hierarchy-Aware cache Replacement Policy). SHARP efficiently defends against all existing cross-core shared-cache attacks, needs only minimal hardware modifications, and requires no code modifications. We implement SHARP in a cycle-level full-system simulator. We show that it protects against real-world attacks, and that it introduces negligible average performance degradation.
Porcine UL16-Binding Protein 1 Expressed on the Surface of Endothelial Cells Triggers Human NK Cytotoxicity through NKG2D1

Cellular rejection mechanisms, including NK cells, remain a hurdle for successful pig-to-human xenotransplantation. Human anti-pig NK cytotoxicity depends on the activating receptor NKG2D. Porcine UL16-binding protein 1 (pULBP1) and porcine MHC class I chain-related protein 2 (pMIC2) are homologues of the human NKG2D ligands ULBP 1–4 and MICA and B, respectively. Although transcribed in porcine endothelial cells (pEC), it is not known whether pULBP1 and pMIC2 act as functional ligands for human NKG2D. In this study, surface protein expression of pULBP1 was demonstrated by flow cytometry using a novel pULBP1-specific polyclonal Ab and by cellular ELISA using NKG2D-Fc fusion protein. Reciprocally, pULBP1-Fc bound to primary human NK cells, whereas pMIC2-Fc did not. Transient and stable down-regulation of pULBP1 mRNA in pEC using short-interfering RNA oligonucleotide duplexes and short hairpin RNA, respectively, resulted in a partial inhibition of xenogeneic NK cytotoxicity through NKG2D in 51Cr release assays. In contrast, down-regulation of pMIC2 mRNA did not inhibit NK cytotoxicity. Human NK cytotoxicity against pEC mediated by freshly isolated or IL-2-activated NK cells through NKG2D was completely blocked using anti-pULBP1 polyclonal Ab. In conclusion, this study suggests that pULBP1 is the predominant, if not only, functional porcine ligand for human NKG2D. Thus, the elimination of pULBP1 on porcine tissues represents an attractive target to protect porcine xenografts from human NK cytotoxicity.
BACE1 RNA interference improves spatial memory and attenuates Aβ burden in a streptozotocin‐induced tau hyperphosphorylated rat model

Both senile plaques and intracellular neurofibrillary tangles are important pathological characteristics in Alzheimer's disease. However, the relationship between Aβ deposition and tau hyperphosphorylation is unknown. In this study, the increased levels of full‐length amyloid precursor protein (APP), APP C‐terminal fragment (β‐CTF) and BACE1 were found in streptozotocin‐induced tau hyperphosphorylation models by quantitative polymerase chain reaction, Western blotting and immunohistochemistry methods. In the previous studies, few strategies focusing on inhibiting β‐secretase (BACE1) in a tau hyperphosphorylation model were utilized. Here, BACE1 RNAi was used to treat the streptozotocin‐induced tau hyperphosphorylation animal models. BACE1 RNAi treatment improved the behavioural ability of animal models and reduced the amount of Aβ1‐40 and Aβ1‐42, accompanied by decreasing the levels of BACE1 and β‐CTF. Our results demonstrated that neurological defects and neurotoxic fragments, including Aβ and β‐CTF, were eliminated by BACE1 RNAi in the tau hyperphosphorylated model, implying the efficiency and safety of BACE1RNAi treatment against Alzheimer's disease. Copyright © 2014 John Wiley & Sons, Ltd.
Prevalence and extent of long oval canals in the apical third.

OBJECTIVE The aim of this study was to investigate the canal diameters in the apical roots of human teeth to determine prevalence and extent of long oval canals. STUDY DESIGN This investigation was carried out on 180 extracted human teeth, 20 for each tooth group. Each root was horizontally sectioned at 1, 2, 3, 4, and 5 mm from the apex. Canal diameters were measured with a measuring microscope. RESULTS In 293 (25%) of the 1181 cross sections investigated, a long oval canal (the long canal diameter was at least 2 times the short canal diameter) was identified. In some tooth groups, the percentage of long oval canals exceeded 50%. In most cases, the long diameter decreased apically; that is, the canal tended toward a rounder cross section. A wide range of diameters existed in all canals. CONCLUSION Long oval canal is common in the apical 5 mm in human teeth. Many long and narrow oval canals would be impossible to instrument completely without perforating or significantly weakening the roots. Care should be taken in cleaning, shaping, and obturating these oval canals.
Sex Differences in Urinary Levels of Several Biological Indicators of Exposure: A Simulation Study Using a Compartmental-Based Toxicokinetic Model

Toxicokinetic modeling is a useful tool to describe or predict the behavior of a chemical agent in the human or animal organism. A general model based on four compartments was developed in a previous study to quantify the effect of human variability on a wide range of biological exposure indicators. The aim of this study was to adapt this existing general toxicokinetic model to three organic solvents—methyl ethyl ketone, 1-methoxy-2-propanol, and 1,1,1,-trichloroethane—and to take into account sex differences. In a previous human volunteer study we assessed the impact of sex on different biomarkers of exposure corresponding to the three organic solvents mentioned above. Results from that study suggested that not only physiological differences between men and women but also differences due to sex hormones levels could influence the toxicokinetics of the solvents. In fact the use of hormonal contraceptive had an effect on the urinary levels of several biomarkers, suggesting that exogenous sex hormones could influence CYP2E1 enzyme activity. These experimental data were used to calibrate the toxicokinetic models developed in this study. Our results showed that it was possible to use an existing general toxicokinetic model for other compounds. In fact, most of the simulation results showed good agreement with the experimental data obtained for the studied solvents, with a percentage of model predictions that lies within the 95% confidence interval varying from 44.4 to 90%. Results pointed out that for same exposure conditions, men and women can show important differences in urinary levels of biological indicators of exposure. Moreover, when running the models by simulating industrial working conditions, these differences could be even more pronounced. A general and simple toxicokinetic model, adapted for three well-known organic solvents, allowed us to show that metabolic parameters can have an important impact on the urinary levels of the corresponding biomarkers. These observations give evidence of an interindividual variability, an aspect that should have its place in the approaches for setting limits of occupational exposure.
A Class-based Language Model Approach to Chinese Named Entity Identification

This paper presents a method of Chinese named entity (NE) identification using a class-based language model (LM). Our NE identification concentrates on three types of NEs, namely, personal names (PERs), location names (LOCs) and organization names (ORGs). Each type of NE is defined as a class. Our language model consists of two sub-models: (1) a set of entity models, each of which estimates the generative probability of a Chinese character string given an NE class; and (2) a contextual model, which estimates the generative probability of a class sequence. The class-based LM thus provides a statistical framework for incorporating Chinese word segmentation and NE identification in a unified way. This paper also describes methods for identifying nested NEs and NE abbreviations. Evaluation based on a test data with broad coverage shows that the proposed model achieves the performance of state-of-the-art Chinese NE identification systems.
Associated Factors for Tuberculosis Recurrence in Taiwan: A Nationwide Nested Case-Control Study from 1998 to 2010

Background The contribution of human immunodeficiency virus (HIV) co-infection to tuberculosis (TB) recurrence is well established worldwide. We conducted this study to investigate associated factors for recurrent TB in Taiwan, which has a relatively low prevalence of HIV. Methods A case-control study nested within a nationwide population-based cohort was performed using the Taiwan National Health Insurance (NHI) database from 1998 to 2010. Patients with notified TB were identified according to diagnosis codes and prescriptions of anti-TB drugs for more than 60 days. Recurrent TB was defined as cases being retreated for more than 60 days and 6 months after the end of previous TB episode. Four controls were randomly selected from cohort and matched to each case by observational period within a calendar year. Socio-demographic variables and comorbidities were evaluated as factors associated with TB recurrence. Results There were totally 760 patients being investigated (608 controls and 152 cases). During an average 5.12 years of follow-up, 3.76% of all developed recurrent TB and the incidence of TB recurrence was 734 per 100,000 person-years. About half of recurrence (55%) was notified within three years of follow-up, and most (86%) recurrences were intrapulmonary. Independent associated factors for TB recurrence included: male (odds ratio, OR: 2.23, 95% confidence interval, CI: 1.40–3.53), diabetes mellitus (DM) (OR: 1.51, 95% CI: 1.02–2.13), chronic obstructive pulmonary disease (COPD) (OR: 1.59, 95% CI: 1.08–2.36) and lower socio-economic status (p=0.001 between groups). Conclusions Despite low prevalence of HIV in the Taiwanese population, the incidence of recurrent TB among Taiwanese was not less than that of other countries. Identification of subgroups such as male gender, low economic status, DM and COPD should be a high priority in TB control programs.
Learned communicative non-use is a reality in very early aphasia recovery: Preliminary results from an ongoing observational study.

Recent neurorehabilitation literature in animal motor models suggests very early (before day five post-stroke) intensive (over 300 repetitions) leads to histological damage (Krakauer et al, 2012) and late rehabilitation (commenced after day 30 post-stroke) is much less effective than intervention started earlier in recovery. The intricacies of directly applying animal models of stroke recovery and rehabilitation to human language have been well documented (Varley, 2011). In humans, the first 90 days post-stroke however, are believed to be the "window of opportunity” (Meyer et al., 2010) for neuronal changes to occur as part of neuroplasticity. Research investigating human stroke recovery models, indicates that the timing of commencement of therapy combined with therapy intensity are likely to be pivotal elements in overall stroke recovery (Kerr et al, 2011). Therapy intensity to facilitate stroke recovery in humans is noted to be far less than that in animal models (Krakauer at al., 2012). Research investigating overall activity levels in stroke survivors in the acute recovery demonstrated that patients spent only 13% of their time engaged in activity and spent 60% of the time alone (Berhardt et al, 2004). Further research showed that task specific movement practice occurred in only 51% of sessions during acute and sub-acute therapy sessions (Lang et al., 2009). Similarly, aphasia research in early stroke recovery demonstrated that on average stroke survivors received between 14 minutes (Godecke et al, 2011) and 1.3 hours (Bowen et al, 2012) of therapy per week during the first month post-stroke. To better understand the interactions that occur in early stroke recovery, this study focused on observed communicative activities that may underlie the neuroplasticity principles of “use it or lose it”, and “learned non-use” (Kleim 2011).
Attention – oscillations and neuropharmacology

Attention is a rich psychological and neurobiological construct that influences almost all aspects of cognitive behaviour. It enables enhanced processing of behaviourally relevant stimuli at the expense of irrelevant stimuli. At the cellular level, rhythmic synchronization at local and long‐range spatial scales complements the attention‐induced firing rate changes of neurons. The former is hypothesized to enable efficient communication between neuronal ensembles tuned to spatial and featural aspects of the attended stimulus. Recent modelling studies suggest that the rhythmic synchronization in the gamma range may be mediated by a fine balance between N‐methyl‐d‐aspartate and α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate postsynaptic currents, whereas other studies have highlighted the possible contribution of the neuromodulator acetylcholine. This review summarizes some recent modelling and experimental studies investigating mechanisms of attention in sensory areas and discusses possibilities of how glutamatergic and cholinergic systems could contribute to increased processing abilities at the cellular and network level during states of top‐down attention.
Do Left-Handed Competitors Have an Innate Superiority in Sports?

This study assessed handedness distributions among (a) sporting competitors (n = 1,112) and nonsporting university students (n = 1,112), (b) sporting competitors engaging in interactive (n = 576) and in noninteractive sports (n = 536), and (c) sporting competitors engaging in direct interactive (n = 219) and indirect interactive (n = 357) sports. Chi-squared showed that there were statistically significant differences in proportions of left-handed persons in (a) sporting competitors and nonsporting university students, (b) sporting competitors engaging in interactive and noninteractive sports, (c) sporting competitors engaging in interactive sports and nonsporting university students, and (d) sporting competitors engaging in direct interactive and indirect interactive sports. It appears that left-handers are more common among those who engage in competitive manual activities. This superiority of the left-handers may be fully explained by a consideration of tactical or strategic factors associated with handedness during sporting interactions. The results with important implications for the measurement and evaluation of handedness are discussed in the light of the current findings on laterality.
Problems paying out-of-pocket medication costs among older adults with diabetes.

OBJECTIVE To identify problems faced by older adults with diabetes due to out-of-pocket medication costs. RESEARCH DESIGN AND METHODS In this cross-sectional national survey of 875 adults with diabetes treated with hypoglycemic medication, respondents reported whether they had underused prescription medications due to cost pressures or had experienced other financial problems associated with medication costs such as forgoing basic necessities. Respondents also described their interactions with clinicians about medication costs. RESULTS A total of 19% of respondents reported cutting back on medication use in the prior year due to cost, 11% reported cutting back on their diabetes medications, and 7% reported cutting back on their diabetes medications at least once per month. Moreover, 28% reported forgoing food or other essentials to pay medication costs, 14% increased their credit card debt, and 10% borrowed money from family or friends to pay for their prescriptions. Medication cost problems were especially common among respondents who were younger, had higher monthly out-of-pocket costs, and had no prescription drug coverage. In general, few respondents, including those reporting medication cost problems, reported that their health care providers had given them information or other assistance to address medication cost pressures. CONCLUSIONS Out-of-pocket medication costs pose a significant burden to many adults with diabetes and contribute to decreased treatment adherence. Clinicians should actively identify patients with diabetes who are facing medication cost pressures and assist them by modifying their medication regimens, helping them understand the importance of each prescribed medication, providing information on sources of low-cost drugs, and linking patients with coverage programs.
KIF14 and citron kinase act together to promote efficient cytokinesis

Multiple mitotic kinesins and microtubule-associated proteins (MAPs) act in concert to direct cytokinesis (Glotzer, M. 2005. Science. 307:1735–1739). In anaphase cells, many of these proteins associate with an antiparallel array of microtubules termed the central spindle. The MAP and microtubule-bundling protein PRC1 (protein-regulating cytokinesis 1) is one of the key molecules required for the integrity of this structure (Jiang, W., G. Jimenez, N.J. Wells, T.J. Hope, G.M. Wahl, T. Hunter, and R. Fukunaga. 1998. Mol. Cell. 2:877–885; Mollinari, C., J.P. Kleman, W. Jiang, G. Schoehn, T. Hunter, and R.L. Margolis. 2002. J. Cell Biol. 157:1175–1186). In this study, we identify an interaction between endogenous PRC1 and the previously uncharacterized kinesin KIF14 as well as other mitotic kinesins (MKlp1/CHO1, MKlp2, and KIF4) with known functions in cytokinesis (Hill, E., M. Clarke, and F.A. Barr. 2000. EMBO J. 19:5711–5719; Matuliene, J., and R. Kuriyama. 2002. Mol. Biol. Cell. 13:1832–1845; Kurasawa, Y., W.C. Earnshaw, Y. Mochizuki, N. Dohmae, and K. Todokoro. 2004. EMBO J. 23:3237–3248). We find that KIF14 targets to the central spindle via its interaction with PRC1 and has an essential function in cytokinesis. In KIF14-depleted cells, citron kinase but not other components of the central spindle and cleavage furrow fail to localize. Furthermore, the localization of KIF14 and citron kinase to the central spindle and midbody is codependent, and they form a complex depending on the activation state of citron kinase. Contrary to a previous study (Di Cunto, F., S. Imarisio, E. Hirsch, V. Broccoli, A. Bulfone, A. Migheli, C. Atzori, E. Turco, R. Triolo, G.P. Dotto, et al. 2000. Neuron. 28:115–127), we find a general requirement for citron kinase in human cell division. Together, these findings identify a novel pathway required for efficient cytokinesis.
Efficient Sparse Recovery Pursuits with Least Squares

We present a new greedy strategy, with an efficient implementation technique, that enjoys similar computational complexity and stopping criteria like OMP. Moreover, its recovery performance in the noise free and the Gaussian noise cases is comparable and in many cases better than other existing sparse recovery algorithms both with respect to the theoretical and empirical reconstruction ability. Our framework has other appealing properties. Convergence is always guaranteed by design also in the case that the recovery conditions are violated. In addition, our implementation method is useful for improving the computational costs of other greedy pursuits such as orthogonal least squares (OLS).