Miracle-dz/UniFAR-FTUs huggingface dataset:
SSEDIC.2020 on mobile eid

Mobile electronic identity (eID) management solutions are on the rise worldwide and see a rapid take-up by stakeholders. In this paper experts from the SSEDIC.2020 network study and review the status of mobile eID deployment and use in e-government as well as industry with a focus on Europe. The findings demonstrate that mobile eID solutions have the potential to become a major means for digital identification but significant efforts still must be made to drive broad adoption across European member states, to guide secure integration of mobile solutions in the industry and to arrive at dedicated standards.
Nanoengineering of anisotropic materials for creating the active optical cells with increased energy efficiency

In this paper the state-of-the-art for exploiting the unique physical and chemical properties of crystalline materials and their possible applications for development of crystalline nanocomposites with the tailored anisotropy were discussed. Using a method of growing crystals from a solution the KDP and TGS nanocrystalites were grown in the mezopores of the AI2O3 matrix. To investigate the developed nanocrystalline samples the X-ray analysis was used. A form of the obtained diffractograms and our calculations show the predominant crystallization of the KDP and TGS in the direction [100], which coincides with the direction of the cylindrical pores. Thus, diffractograms contain only reflexes of crystallographic planes (200) and (400). The achieved result indicates the possibility of growing of nanocrystals in mesopores of such AI2O3 structures developed by us and provides the prospect of creating optical cells with increased energy efficiency.
Biosynthesis of novel 7,8‐dihydroxyflavone glycoside derivatives and in silico study of their effects on BACE1 inhibition

7,8‐Dihydroxyflavone (7,8‐DHF) has been conjugated with glucose moiety to produce glucoside derivatives. Three analogues of 7,8‐DHF (7‐O‐β‐d‐glucosyl‐8‐hydroxyflavone, 7‐hydroxy‐8‐O‐β‐d‐glucosyl flavone, and 7,8‐di‐O‐β‐d‐glucosylflavone) have been successfully produced from in vitro reaction using glycosyltransferase of Bacillus licheniformis. Production of these 7,8‐DHF derivatives were shifted to cheaper and easier approach in this study by using engineered Escherichia coli BL21 (DE3) ΔpgiΔzwfΔushA cells in which the flow of glucose‐6‐phospahte toward glycolysis and pentose phosphate pathway and hydrolysis of UDP‐α‐d‐glucose were blocked while directing the carbon flux toward UDP‐α‐d‐glucose by overexpressing UDP‐α‐d‐glucose pathway genes. Supplementation of 300 μM of 7,8‐DHF to the culture resulted in production of 171 μM of 7‐O‐β‐d‐glucosyl‐8‐hydroxyflavone, 68 μM of 7‐hydroxy‐8‐O‐β‐d‐glucoxyflavone, and 55 μM of 7,8‐di‐O‐β‐d‐glucoxyflavone in laboratory‐scale 3‐L fermentor, representing 98% bioconversion of initially fed substrate to respective glucoside derivatives within 48 H. These products were characterized by high‐performance liquid chromatography‐photodiode array (HPLC‐PDA), HPLC‐PDA‐quadruple time of flight‐electron spray ionization mass spectrometry, and nuclear magnetic resonance analyses. These newly synthesized derivatives were found to be able to interact with amino acids of active site of human β‐site amyloid precursor protein cleaving β‐site amyloid precursor protein cleaving enzyme 1 (BACE1) β‐secretase enzyme in in silico studies, thus displaying possible application in cure of Alzheimer's disease.
Features of the hardware implementation of real time Hough transform on FPGA

Hough transform is a widely used computer vision algorithm. It allows to recognize objects that can be deﬁned by the parametric function in digital images. In real-time machine vision systems that analyze video stream from digital cameras the time of processing of a single frame is extremely important. The hardware implementation of the algorithm on Field-Programmable Gate Array (FPGA) reduce the processing time by using parallel computing and quick access to embedded memory. However, the hardware implementation has a number of features. To achieve the results, the structure and principles of the FPGA operation have to well known as well as principles of FPGA interaction with the environment.
The role of skeletal muscle contractile duration throughout the whole day: reducing sedentary time and promoting universal physical activity in all people

A shared goal of many researchers has been to discover how to improve health and prevent disease, through safely replacing a large amount of daily sedentary time with physical activity in everyone, regardless of age and current health status. This involves contrasting how different muscle contractile activity patterns regulate the underlying molecular and physiological responses impacting health‐related processes. It also requires an equal attention to behavioural feasibility studies in extremely unfit and sedentary people. A sound scientific principle is that the body is constantly sensing and responding to changes in skeletal muscle metabolism induced by contractile activity. Because of that, the rapid time course of health‐related responses to physical inactivity/activity patterns are caused in large part directly because of the variable amounts of muscle inactivity/activity throughout the day. However, traditional modes and doses of exercise fall far short of replacing most of the sedentary time in the modern lifestyle, because both the weekly frequency and the weekly duration of exercise time are an order of magnitude less than those for people sitting inactive. This can explain why high amounts of sedentary time produce distinct metabolic and cardiovascular responses through inactivity physiology that are not sufficiently prevented by low doses of exercise. For these reasons, we hypothesize that maintaining a high metabolic rate over the majority of the day, through safe and sustainable types of muscular activity, will be the optimal way to create a healthy active lifestyle over the whole lifespan.
N ov 2 01 0 Hidden Conformal Symmetry of Extremal Kerr-Bolt

We show that extremal Kerr-Bolt spacetimes have a hidden conformal symmetry. In this regard, we consider the wave equation of a massless scalar field propagating in extremal Kerr-Bolt spacetimes and find in the ”near region”, the wave equation in extremal limit can be written in terms of the SL(2, R) quadratic Casimir. Moreover, we obtain the microscopic entropy of the extremal KerrBolt spacetimes also we calculate the correlation function of a nearregion scalar field and find perfect agreement with the dual 2D CFT. rezakord@ipm.ir vkamali1362@gmail.com
A Dividerless PLL With Low Power and Low Reference Spur by Aperture-Phase Detector and Phase-to-Analog Converter

A 2.1-GHz dividerless PLL with low power, low reference spur and low in-band phase noise is introduced in this paper. A new phase detection mechanism using aperture-phase detector (APD) and phase-to-analog converter (PAC) generates an analog voltage in proportion to the phase error between reference and VCO, and then controls the current amplitude of the following charge pump (CP). The charging and discharging currents in the proposed CP have equal pulse width and equal small amplitude in locked state, which reduces the reference spur and power consumption of the CP effectively. Moreover, compared to the conventional CP with the same bias current in locked state, the proposed CP can contribute a much lower noise to the PLL output. In addition, a method of tunable loop gain with theoretical analysis is introduced to reduce the PLL output jitter. The proposed PLL is fabricated in a standard 0.13-μm CMOS process. It consumes 2.5 mA from a 1.2-V supply voltage and occupies a core area of 0.48 mm × 0.86 mm. The reference spur of the proposed PLL is measured to be -80 dBc/-74 dBc and an in-band phase noise of -103 dBc/Hz at 100 kHz offset is achieved.
CATHODIC PROTECTION OF A BRIDGE DECK

An electrically conductive asphalt concrete was made by substituting coke breeze for the natural aggregate. Paving a bridge deck with the electrically conductive asphalt concrete indicated that cathodic protection could be applied to the reinforcing steeL The cathodic protection was measured to be effective when the corrosion of steel strips embedded in concrete containing 10 percent calcium chloride by weight of the cement was stopped. It is estimated that, for the approximately 3,300 ft (307.6 m ) of bridge deck under cathodic protection, the top mat of reinforcing steel has an applied current density of 0.7 mA/ft2 (7.5 mA/m ) of steel surface. The total current used is about 1.0 A with a driving voltage of 1.65 V for a total power requirement of 1.65 W. As an experimental method of repair, 2 polymers and an epoxy were injected to bond the undersurface fractures. The epoxy could be injected in all cases where the concrete emitted a hollow sound when struck with a hammer. However, the epoxy could not be injected when the concrete emitted a hollow sound from only the use of the chain drag but not from the use of the hammer. The cost of the cathodic protection installation is estimated to be about $3/ft2 of deck ($33/m).
Effectiveness of interventions for the development of leadership skills among nurses: a systematic review protocol.

REVIEW QUESTION/OBJECTIVE What interventions are the most effective for the development of leadership skills for nurses? The review objective is to systematically review the evidence to identify the effectiveness of interventions for the development of leadership skills among nurses. CENTER CONDUCTING THE REVIEW Centre for Evidence-based Initiatives in Health Care - University of Wollongong: an Affiliate Center of the Joanna Briggs Institute.
Frequency-Domain Prediction for Audio Coding

Minimization of temporal redundancy in perceptual and lossless audio transform coding using backwardor forwardadaptive linear prediction has been a subject of intensive scientific investigation. The computational complexity of most conventional approaches, however, is considerable. In this paper we present a forward-adaptive predictor which is guided by a single eight-bit periodicity parameter per frame and channel and which, owing to its direct integration into the modified discrete cosine transform (MDCT) domain of the codec, operates with very low complexity. It is shown that our frequency-domain prediction (FDP) method may also be used to improve the performance of state-of-the-art joint-channel coding schemes. The results of a blind listening test indicate that, in the context of the MPEG-H 3D Audio codec, the FDP technique leads to small but significant coding quality gains.
An Experimental Investigation of Variation Operators in Reference-Point Based Many-Objective Optimization

Reference-point based multi-objective evolutionary algorithms (MOEAs) have shown promising performance in many-objective optimization. However, most of existing research within this area focused on improving the environmental selection procedure, and little work has been done on the effect of variation operators. In this paper, we conduct an experimental investigation of variation operators in a typical reference-point based MOEA, i.e., NSGA-III. First, we provide a new NSGA-III variant, i.e., NSGA-III-DE, which introduces differential evolution (DE) operator into NSGA-III, and we further examine the effect of two main control parameters in NSGA-III-DE. Second, we have an experimental analysis of the search behavior of NSGA-III-DE and NSGA-III. We observe that NSGA-III-DE is generally better at exploration whereas NSGA-III normally has advantages in exploitation. Third, based on this observation, we present two other NSGA-III variants, where DE operator and genetic operators are simply combined to reproduce solutions. Experimental results on several benchmark problems show that very encouraging performance can be achieved by three suggested new NSGA-III variants. Our work also indicates that the performance of NSGA-III is significantly bottlenecked by its variation operators, providing opportunities for the study of the other alternative ones.
An approach based on resampling and feature selection to improve the classification of microarray data

DNA microarray technology has emerged as a potential tool for diagnosis and classification of the cancer. Hence, it has encountered challenges like high volume of features and low number of samples. This paper presents a method which uses advantages of feature selection techniques and resampling in order to improve the classification accuracy. First, by using information gain feature selection, dimensions of dataset decreases. Then, synthetic minority oversampling technique was used in order to increase minority class samples. In the next step, using correlation-based feature selection, the most reliable features selected and entered into Naive Bayesian classifier for classification. Results of the experiments indicate the improvement of classification accuracy.
A review of the growing risk of vitamin D toxicity from inappropriate practice

Vitamin D is a particularly important sterol hormone, with evidence emerging of its beneficial effects well beyond bone. In consequence of this and increased global recognition of vitamin D deficiency in the general population, there has been a resurgence in treatment with vitamin D preparations. However, the increasing use of vitamin D treatments has also seen a substantial increase in the number of reports of vitamin D intoxication, with the majority (75%) of reports published since 2010. Many of these cases are a consequence of inappropriate prescribing, and the use of high‐dose over‐the‐counter preparations or unlicensed preparations. This review highlights that the majority of cases were preventable and discusses the inappropriate use of poorly formulated, and unlicensed vitamin D preparations.
Lipopolysaccharide-induced inflammation in monocytes/macrophages is blocked by liposomal delivery of Gi-protein inhibitor

Background Lipopolysaccharide (LPS) is widely recognized as a potent activator of monocytes/macrophages, and its effects include an altered production of key mediators, such as inflammatory cytokines and chemokines. The involvement of Gi protein in mediating LPS effects has been demonstrated in murine macrophages and various cell types of human origin. Purpose The aim of the present work was to evaluate the potential of a Gi-protein inhibitor encapsulated in liposomes in reducing the inflammatory effects induced by LPS in monocytes/macrophages. Materials and methods Guanosine 5′-O-(2-thiodiphosphate) (GOT), a guanosine diphosphate analog that completely inhibits G-protein activation by guanosine triphosphate and its analogs, was encapsulated into liposomes and tested for anti-inflammatory effects in LPS-activated THP1 monocytes or THP1-derived macrophages. The viability of monocytes/macrophages after incubation with different concentrations of free GOT or liposome-encapsulated GOT was assessed by MTT assay. MAPK activation and production of IL1β, TNFα, IL6, and MCP1 were assessed in LPS-activated monocytes/macrophages in the presence or absence of free or encapsulated GOT. In addition, the effect of free or liposome-encapsulated GOT on LPS-stimulated monocyte adhesion to activated endothelium and on monocyte chemotaxis was evaluated. Results We report here that GOT-loaded liposomes inhibited activation of MAPK and blocked the production of the cytokines IL1β, TNFα, IL6, and MCP1 induced by LPS in monocytes and macrophages. Moreover, GOT encapsulated in liposomes reduced monocyte adhesion and chemotaxis. All demonstrated events were in contrast with free GOT, which showed reduced or no effect on monocyte/macrophage activation with LPS. Conclusion This study demonstrates the potential of liposomal GOT in blocking LPS proinflammatory effects in monocytes/macrophages.
An Equilibrium Analysis of Search and Breach of Contract, I: Steady States

We study the steady-state equilibrium of models where individuals meet pairwise in a costly stochastic search process and negotiate contracts to product output. Different meetings yield different outputs, and so an individual in a contract may wish to continue search to find a better match. If he is successful, he will break his original contract. In anticipation of possible breaches, contracts may provide for compensation to be paid to the breached-against partner. We examine the effects that several alternative damage rules have on equilibrium search and breach behavior.
Empirical Study on National Equities Exchange and Quotations under Market-maker System with VaR method Based on GARCH Model

This paper conducts empirical research and regulations on the risk of National Equities Exchange and Quotations under the market-maker system in China, and outlines the VaR method based on GARCH model after summarizing the domestic and foreign literatures on the risk measurement and control of NEEQ market-maker system, then performs empirical study on risk measurement of the market maker index of NEEQ, and verifing VaR values of the sample data with failure frequency test method based on the calculation of VaR values. The results show that VaR method based on the GARCH model can be effectively applied to the risk management of NEEQ under the market-maker system in China.
Cranial Ontogeny in Stegoceras validum (Dinosauria: Pachycephalosauria): A Quantitative Model of Pachycephalosaur Dome Growth and Variation

Historically, studies of pachycephalosaurs have recognized plesiomorphically flat-headed taxa and apomorphically domed taxa. More recently, it has been suggested that the expression of the frontoparietal dome is ontogenetic and derived from a flat-headed juvenile morphology. However, strong evidence to support this hypothesis has been lacking. Here we test this hypothesis in a large, stratigraphically constrained sample of specimens assigned to Stegoceras validum, the best known pachycephalosaur, using multiple independent lines of evidence including conserved morphology of ornamentation, landmark-based allometric analyses of frontoparietal shape, and cranial bone histology. New specimens show that the diagnostic ornamentation of the parietosquamosal bar is conserved throughout the size range of the sample, which links flat-headed specimens to domed S. validum. High-resolution CT scans of three frontoparietals reveal that vascularity decreases with size and document a pattern that is consistent with previously proposed histological changes during growth. Furthermore, aspects of dome shape and size are strongly correlated and indicative of ontogenetic growth. These results are complementary and strongly support the hypothesis that the sample represents a growth series of a single taxon. Cranial dome growth is positively allometric, proceeds from a flat-headed to a domed state, and confirms the synonymy of Ornatotholus browni as a juvenile Stegoceras. This dataset serves as the first detailed model of growth and variation in a pachycephalosaur. Flat-headed juveniles possess three characters (externally open cranial sutures, tuberculate dorsal surface texture, and open supratemporal fenestrae) that are reduced or eliminated during ontogeny. These characters also occur in putative flat-headed taxa, suggesting that they may also represent juveniles of domed taxa. However, open cranial sutures and supratemporal fenestrae are plesiomorphic within Ornithischia, and thus should be expected in the adult stage of a primitive pachycephalosaur. Additional lines of evidence will be needed to resolve the taxonomic validity of flat-headed pachycephalosaur taxa.
Comparative Effectiveness of Levetiracetam vs Phenobarbital for Infantile Epilepsy

Importance More than half of infants with new-onset epilepsy have electroencephalographic and clinical features that do not conform to known electroclinical syndromes (ie, nonsyndromic epilepsy). Levetiracetam and phenobarbital are the most commonly prescribed medications for epilepsy in infants, but their comparative effectiveness is unknown. Objective To compare the effectiveness of levetiracetam vs phenobarbital for nonsyndromic infantile epilepsy. Design, Setting, and Participants The Early Life Epilepsy Study—a prospective, multicenter, observational cohort study conducted from March 1, 2012, to April 30, 2015, in 17 US medical centers—enrolled infants with nonsyndromic epilepsy and a first afebrile seizure between 1 month and 1 year of age. Exposures Use of levetiracetam or phenobarbital as initial monotherapy within 1 year of the first seizure. Main Outcomes and Measures The binary outcome was freedom from monotherapy failure at 6 months, defined as no second prescribed antiepileptic medication and freedom from seizures beginning within 3 months of initiation of treatment. Outcomes were adjusted for demographics, epilepsy characteristics, and neurologic history, as well as for observable selection bias using propensity score weighting and for within-center correlation using generalized estimating equations. Results Of the 155 infants in the study (81 girls and 74 boys; median age, 4.7 months [interquartile range, 3.0-7.1 months]), those treated with levetiracetam (n = 117) were older at the time of the first seizure than those treated with phenobarbital (n = 38) (median age, 5.2 months [interquartile range, 3.5-8.2 months] vs 3.0 months [interquartile range, 2.0-4.4 months]; P < .001). There were no other significant bivariate differences. Infants treated with levetiracetam were free from monotherapy failure more often than those treated with phenobarbital (47 [40.2%] vs 6 [15.8%]; P = .01). The superiority of levetiracetam over phenobarbital persisted after adjusting for covariates, observable selection bias, and within-center correlation (odds ratio, 4.2; 95% CI, 1.1-16; number needed to treat, 3.5 [95% CI, 1.7-60]). Conclusions and Relevance Levetiracetam may have superior effectiveness compared with phenobarbital for initial monotherapy of nonsyndromic epilepsy in infants. If 100 infants who received phenobarbital were instead treated with levetiracetam, 44 would be free from monotherapy failure instead of 16 by the estimates in this study. Randomized clinical trials are necessary to confirm these findings.
Effects of a Combination of Thyme and Oregano Essential Oils on TNBS-Induced Colitis in Mice

We examined the anti-inflammatory effects of the combination of thyme and oregano essential oil dietary administered at three concentrations (0.4% thyme and 0.2% oregano oils; 0.2% thyme and 0.1% oregano oils; 0.1% thyme and 0.05% oregano oils) on mice with TNBS-induced colitis. Treatment of colitic animals with the essential oils decreased the mRNA levels of pro-inflammatory cytokines IL-1β, IL-6, GM-CSF, and TNFα, especially after application of the medium dose. The medium dose of the essential oils significantly lowered the amount of IL-1β and IL-6 proteins too. Moreover, administration of the medium dose decreased the mortality rate, accelerated the body weight gain recovery, and reduced the macroscopic damage of the colonic tissue. Our results indicate that combined treatment with appropriate concentrations of thyme and oregano essential oils can reduce the production of proinflammatory cytokines, and thereby attenuate TNBS-induced colitis in mice.