Miracle-dz/UniFAR-FTUs huggingface dataset:
Lambert Review of Business-University Collaboration: Final Report

This review of business-university collaborationin the United Kingdom has three objectives: (1) to illustrate opportunitiesarising from changes in ways that business undertakes RD (2) to recognizebusinesses already collaborating with university departments, which are rolemodels for those without university links; and (3) to offer ideas andrecommendations to shape policy. Points out two new trends shaping business world-wide: Firms are doing lessresearch and development (RD and business RD (2) that government mustbetter support business-university collaboration; and (3) that business mustlearn to exploit innovations being developed by universities. Comparatively, UK businesses have low research intensity. Analyzesthedemand for research from business, identifying the need to raisebusiness demand for research from all sources. Some proposals for buildingnetworks among research-intensive businesses and supporting business-universitycollaboration are offered. Also offers recommendations for encouragingcommunication between business people and academics, to support knowledgetransfer. Universities have the potential to transfer knowledge from their strongscience base to business in the form of intellectual property (IP). However, anumber of barriers to commercializing IP are discussed. First is lack ofclarity of IP ownership in collaborations; second is variable quality ofuniversity technology transfer offices; third, more emphasis should be put onlicensing technology and less on developing university spinouts. Because universities play increasing roles in regional economic development,this analysisrecommends English Regional Development Agencies shouldchange their targets to creating relationships between business anduniversities across regions and nations. The current dual support system of university funding had strengths andweaknesses. The analysissuggests that this system offersdisincentives to business-university cooperation. A number of principles toencourage business research are presented, and the UK government is urged toconsider the balance and fill the research funding gap. A voluntary code of governance for university management is suggested, asare strategies for improving professional and entrepreneurial skills forstudents. Overall, the report concludes that despite much good collaborativework, more remains to be done. Four appendixes identify the goals of thereport, give the draft code of governance, summarize its recommendations, andlist contributors to the report. (TNM)
Stabilization of the Z' form of poly(dGdC):poly(dGdC) in solution by multivalent ions relates to the ZII form in crystals.

Both multivalent ions and 85% ethanol are required to produce the original Z' form of poly(dGdC):poly(dGdC) in solution. When multivalent impurities are removed by dialysis against 0.5 M NaCl and 1 mM EDTA, the circular dichroism retains features of the standard Z form. Addition of Ca+2 nearly reverses this effect. Analysis by singular value decomposition of near-ultraviolet circular dichroism spectra collected during titrations of polynucleotide in 60% ethanol with multivalent ions reveal that, at concentrations below . 5 per nucleotide, they stabilize Z'-like forms in a two-state equilibrium with the Z form. Differences among the Z' spectra produced by the different ions suggest that at least three families of Z' structures exist. Furthermore, comparison with crystal data indicates that the Z' form in solution is related to the ZII form in crystals.
Bilateral and Unilateral Hippocampal Inactivation Did not Differ in their Effect on Consolidation Processes in the Morris Water Maze

Consolidation processes were studied in the rat by using functional inactivation techniques. Previous results showed that unilateral hippocampal inactivation alters consolidation. It is not clear if bilateral treatments increase the impairment. Wistar rats were trained in the Morris water maze during 4 consecutive days. Subjects received saline or tetrodotoxin in the dorsal hippocampus 1 min after training. Results showed that bilateral as well as unilateral treatments impair consolidation to the same degree, as shown by the mean latency to reach the platform. In both cases, the impairment is only visible in the first trial of the session following the blockade.
Theoretical evaluation of magnetoreception of power‐frequency fields

Several effects of power‐frequency (50/60 Hz) magnetic fields (PF‐MF) of weak intensity have been hypothesized in animals and humans. No valid mechanism, however, has been proposed for an interaction between PF‐MF and biological tissues and living beings at intensities relevant to animal and human exposure. Here we proposed to consider PF‐MF as disrupters of the natural magnetic signal. Under exposure to these fields, an oscillating field exists that results from the vectorial summation of both the PF‐MF and the geomagnetic field. At a PF‐MF intensity (rms) of 0.5 µT, the peak‐to‐peak amplitude of the axis and/or intensity variations of this resulting field exceeds the related discrimination threshold of magnetoreception (MR) in migrating animals. From our evaluation of the 50/60 Hz responsiveness of the putative mechanisms of MR, single domain particles (Kirschvink's model) appear unable to transduce that oscillating signal. On the contrary, radical pair reactions are able to, as well as interacting multidomain iron–mineral platelets and clusters of superparamagnetic particles (Fleissner/Solov'yov's model). It is, however, not yet known whether the reception of 50/60 Hz oscillations of the natural magnetic signal might be of consequence or not. Bioelectromagnetics 31:371–379, 2010. © 2010 Wiley‐Liss, Inc.
Cyclicality of Wage Structure and Vintage-Capital-Skill Complementarity

This study examines profiles and cyclical patterns of schooling and experience prices over the 1961 2012 period. To account for different channels that drive cyclical fluctuations of skill prices we distinguish between two types of productivity shocks: technological change and neutral productivity shock. Following the wage structure literature, our empirical estimations control for potential channels that could shift the supply and demand for skills. We document that the experience premium is negatively correlated with both types of shocks. Schooling premium is positively correlated with the technological change but does not vary with the neutral productivity shock. To examine these findings, we extend the capital-skill complementarity framework to incorporate education, vintage human capital and vintage capital equipment. Human capital and match quality theories suggest that vintage human capital is more complementary with vintage capital equipment than with new capital equipment, whereas new human capital is more complementary with new technologies. We incorporate these complementarity assumptions and show that our extended model generates patterns of skill prices observed in the data. JEL Classification: E24, E32, J24, J31
ACCELERATED DEATH OF AEROBACTER AEROGENES STARVED IN THE PRESENCE OF GROWTH-LIMITING SUBSTRATES.

Summary: Substrate-accelerated death (Postgate & Hunter, 1963a) was observed with glycerol-, glucose-, ribose-, ammonium- or phosphate-limited populations of Aerobacter aerogenes grown in defined media and starved in non-nutrient buffer; sulphate- or magnesium-limited organisms did not show this. Glucose or pyruvate accelerated death of starved populations obtained from a complex medium. Lactate-accelerated death of Escherichia coli and glucose-accelerated death of Serratia marcescens were also observed with populations of appropriate nutritional status. Glycerol-accelerated death of glycerol-limited A. aerogenes occurred with organisms from batch or continuous cultures grown at various pH values; it showed a population effect and was particularly pronounced in 0.15 m-NaCl buffered with phosphate. Continued presence of glycerol was necessary and the glycerol was metabolized. Survivors showed prolonged division lags. Tricarboxylic acid cycle intermediates, but not glucose or ribose, also accelerated death. Glycerol-accelerated death was not delayed by malonate, fluoride or fluoracetate; iodo-acetate delayed its onset but did not affect its rate; uncoupling agents antagonized it though they were themselves toxic. Glycerol-accelerated death was not accompanied by accelerated break-down of the osmotic barrier, nor by leakage of materials associated with cold shock nor by acquiring sensitivity to cold shock. No catabolism of DNA or protein accompanied it; polysaccharide was synthesized; no change in the rate of degradation of RNA was observed. Coloured substances, pyridine nucleotides, white-fluorescent material and material which absorbed at 220-230 mμ were released during glycerol-accelerated death. Magnesium ions prevented glycerol-accelerated death.
Miniaturized Wireless Sensing System for Real-Time Breath Activity Recording

A portable, non-invasive and easy to operate wireless system has been developed for monitoring the breathing activity of patient. The system is composed of a capacitive microsensor (airflow-humidity sensor) integrated on a silicon chip and of a Negative Temperature Coefficient thermistor; both are connected to a wireless network to allow efficient healthcare at home as well as in hospitals. The capacitive sensitive part of the microsensor is an array of interdigitated metallic electrodes covered by 100-nm-thick dense anodized aluminum oxide layer. The breath water vapor is adsorbed over the interdigitated electrodes and changes the sensor characteristic capacitance by up to two orders of magnitude. This modulated signal is then digitized and either stored in a memory or directly transmitted to a monitor through a short distance radio frequency (RF) link. Results show that the wireless platform can be powered by two AAA batteries and deployed in a mesh or star configuration as wireless sensor network. Full size of the microsensor is less than 1 cm2 and is conveniently implemented in a classical adhesive bandage or in nasal prongs. This microsystem is proposed for monitoring sleep-disordered breathing as well as breathing rhythm of athletes during effort.
Role of Matrix Metalloproteinases in Migration and Neurotrophic Properties of Nasal Olfactory Stem and Ensheathing Cells

Adult olfactory ectomesenchymal stem cells (OE-MSCs) and olfactory ensheathing cells (OECs), both from the nasal olfactory lamina propria, display robust regenerative properties when transplanted into the nervous system, but the mechanisms supporting such therapeutic effects remain unknown. Matrix metalloproteinases (MMPs) are an important family of proteinases contributing to cell motility and axonal outgrowth across the extracellular matrix (ECM) in physiological and pathological conditions. In this study, we have characterized for the first time in nasal human OE-MSCs the expression profile of some MMPs currently associated with cell migration and invasiveness. We demonstrate different patterns of expression for MMP-1, MMP-2, MMP-9, and MT1-MMP upon cell migration when compared with nonmigrating cells. Our results establish a correspondence between the localization of these proteinases in the migration front with the ability of cells to migrate. Using various modulators of MMP activity, we also show that at least MMP-2, MMP-9, and MT1-MMP contribute to OE-MSC migration in an in vitro 3D test. Furthermore, we demonstrate under the same conditions of culture used for in vivo transplantation that OE-MSCs and OECs secrete neurotrophic factors that promote neurite outgrowth of cortical and dorsal root ganglia (DRG) neurons, as well as axo-dendritic differentiation of cortical neurons. These effects were abolished by the depletion of MMP-2 and MMP-9 from the culture conditioned media. Altogether, our results provide the first evidence that MMPs may contribute to the therapeutic features of OE-MSCs and OECs through the control of their motility and/or their neurotrophic properties. Our data provide new insight into the mechanisms of neuroregeneration and will contribute to optimization of cell therapy strategies.
Radiation-Stimulated ERK1/2 and JNK1/2 Signaling can Promote Cell Cycle Progression in Human Colon Cancer Cells

The abilities of mutated active K-RAS and H-RAS proteins, in an isogenic human carcinoma cell system, to modulate the activity of signaling pathways and cell cycle progression following exposure to ionizing radiation is largely unknown. Loss of K-RAS D13 expression in parental HCT116 colorectal carcinoma cells blunted basal ERK1/2, AKT and JNK1/2 activity by ~70%. P38 activity was not detected. Deletion of the allele to express activated K-RAS nearly abolished radiation-induced activation of all signaling pathways. Expression of H-RAS V12 in HCT116 cells lacking an activated RAS molecule (H-RAS V12 cells) restored basal ERK1/2 and AKT activity to that observed in parental cells, but did not restore or alter basal JNK1/2 and p38 activity. In parental cells radiation (1 Gy) caused stronger ERK1/2 pathway activation compared to that of the PI3K/AKT pathway. In H-RAS V12 cells radiation caused stronger PI3K/AKT pathway activation compared to that of the ERK1/2 pathway. Radiation (1 Gy) promoted S phase entry in parental HCT116 cells within 24h, but not in either HCT116 cells lacking K-RAS D13 expression or in H-RAS V12 cells. In parental cells radiation-stimulated S phase entry correlated with ERK1/2-, JNK1/2- and PI3K-dependent increased expression of cyclin D1 and cyclin A, and to a lesser extent cyclin E, 6–24 h after exposure. Cyclin A and cyclin D1 expression were not increased by radiation in cells lacking K-RAS D13 expression or in H-RAS V12 cells. Radiation (1 Gy) modestly enhanced expression of p53, hMDM2 and p21 in parental cells 2-6h after exposure, which was abolished in cells lacking K-RAS D13 expression. Introduction of H-RAS V12 into cells lacking mutant active RAS partially restored radiation-induced expression of p21 and p53, and enhanced the induction of hMDM2 beyond that observed in parental cells. Collectively, our findings argue that the coordinated activation of multiple signaling pathways, in particular ERK1/2 and JNK1/2, by radiation is required to elevate the expression of G1 and S phase cyclin proteins and to promote S phase entry in human colon carcinoma cells expressing wild type p53. In HCT116 cells H-RAS V12 promotes hMDM2 expression after radiation exposure which correlates with reduced p53 expression and increased cell survival.
Cryptanalysis on two user authentication protocols using smart card for wireless sensor networks

In 2009, M. L. Das has proposed a two-factor user authentication scheme for wireless sensor networks, where each user proves his/her legitimacy using password and smart card. Later, in 2010, He et al.'s demonstrated that M. L. Das protocol suffers from insider attack, impersonation attack and users cannot change their password. Then they proposed enhanced two-factor protocol that copes to the Das's protocol weaknesses. In the same year, Khan-Alghathbar pointed out that Das's protocol is suffered from gateway-bypass attack, and no mutual authentication between the sensor node and the gateway. Then Khan-Alghathbar proposed security improvement on Das's scheme. In this paper, we show that: (1) He et al.'s scheme is susceptible to information leakage attack, and cannot preserve user anonymity, no mutual authentication between the sensor and the user, and does not establish the session key between the user and the sensor node; (2) Khan-Alghathbar scheme does not provide mutual authentication between the sensor and the user, and does not establish the session key between the user and the sensor node, and no confidentiality to their air messages.
A 0.98 to 6.6 Hz Tunable Wideband VCO in a 180nm CMOS Technology for Reconfigurable Radio Transceiver

This paper proposes a novel wideband voltage-controlled oscillator (VCO) for multi-band transceivers. The proposed VCO has a core VCO and a tuning-range extension circuit, which consists of switches, a mixer, dividers, and variable gain combiners with a spurious rejection technique. The experimental results exhibit 0.98-to-6.6 GHz continuous frequency tuning with -206dBc/Hz of FoMT, which is fabricated by using a 0.18 mum CMOS process. The frequency tuning range (FTR) is 149 %, and the chip area is 800 mum x 540 mum.
Role of Group A Streptococcal Virulence Factors in Adherence to Keratinocytes

ABSTRACT To evaluate the role of putative group A streptococcal virulence factors in the initiation of skin infections, we compared the adherence of a wild-type M49-protein skin-associated strain to that of a series of 16 isogenic mutants created by insertional inactivation of virulence genes. None of the mutants, including the M-protein-deficient (emm mutant) strain, displayed reduced adherence to early-passage cultured human keratinocytes, but adherence of the mutant lacking hyaluronic acid capsule expression (has mutant) was increased 13-fold. In contrast, elimination of capsule expression in M2-, M3-, and M18-protein has mutants increased adherence only slightly (1.3- to 2.3-fold) compared to their respective wild-type strains. A mutant with inactivation of both emm andhas displayed high-level adherence (34.9 ± 4.1%) equal to that of the has mutant strain (40.7 + 8.0%), confirming the lack of involvement of M49 protein in attachment. Moreover, adherence of the M49-protein-deficient (emmmutant) and wild-type strains was increased to the same level (57 and 55%, respectively) following enzymatic digestion of their hyaluronic acid capsule. Adherence of mutants lacking oligopeptide permease (Opp) expression was increased 3.8- to 5.5-fold, in association with decreased cell-associated hyaluronic acid capsule. Finally, soluble CD46 failed to inhibit adherence of M49- and M52-serotype skin strains. We conclude that (i) bacterial M protein and keratinocyte CD46 do not mediate adherence of M49 skin-associated Streptococcus pyogenes to epidermal keratinocytes, (ii) hyaluronic acid capsule impedes the interaction of bacterial adhesins with keratinocyte receptors, (iii) modulation of capsule expression may be important in the pathogenesis of skin infections, and (iv) the molecular interactions in attachment of skin strains of S. pyogenesto keratinocytes are unique and remain unidentified.
Teaching stimulus–stimulus relations to minimally verbal individuals: reflections on technology and future directions

ABSTRACT This paper discusses recent methodological approaches and investigations that are aimed at developing reliable behavioral technology for teaching stimulus–stimulus relations to individuals who are minimally verbal and show protracted difficulty in acquiring such relations. The paper has both empirical and theoretical contents. The empirical component presents recent data concerning the possibility of generating rapid relational learning in individuals who do not initially show it. The theoretical component (1) considers decades of methodological investigations with this population and (2) suggests a testable hypothesis concerning some individuals who exhibit unusual difficulties in learning. Given this background, we suggest a way forward to better understand and perhaps resolve these learning challenges.
Adhesion Prevention in Laparoscopic Surgery

Abstract Background: Adhesions have important consequences for patients, surgeons, and health services. Peritoneal-tissue injury can be prevented by using careful surgical techniques. A large number of antiadhesion products have been used experimentally and clinically to prevent postoperative adhesions. Methods: The current author reviewed the surgical literature published about epidemiology, pathogenesis, and various prevention strategies of adhesion formation. Results: Meticulous surgery is essential to reduce unnecessary morbidity and mortality rates from these untoward effects of surgery. Several preventive agents against postoperative peritoneal adhesions have been investigated. Bioresorbable membranes are site-specific antiadhesion products but may be more difficult to use laparoscopically. Liquids and gels have the advantage of more-widespread areas of action and increased ease of use, particularly during laparoscopic operations. Effective pharmacologic agents that can reduce release of proinflamma.
Impact of Chlamydia pneumoniae infection on survival rate after heart transplantation.

BACKGROUND As Chlamydia pneumoniae (Cp), a common cause of respiratory infection, is of vasotropic character, chronic infection may be associated with the development of coronary disease, although there have been few reports on the impact of Cp infection on the post-orthotopic heart transplantation (OHT) survival rate. MATERIAL/METHODS A total of 41 patients (4 females) were followed up for one year after OHT. Serology investigations for IgM, IgG and IgA antibodies against Cp were performed using the enzyme immunoassay (EIA) method. Univariate and multivariate analyses were carried out with respect to IgA, IgG, gender and type of cardiomyopathy. The IgA-IgG joint effect was also studied. RESULTS The one-year survival rate was reported for patients with IgA < 8 EIU to be 72.2%, whereas those with IgA >or= 8 EIU accounted for only 43.5% (Kaplan-Meier analysis, p = 0.0548). In multivariate analysis IgA /IgG status proved to be a highly significant factor in survival. IgA positive outcome combined with IgG negative outcome showed that the relative risk of death equaled 12.08 versus other combinations of IgA/IgG status. In the Cox multivariate model ischemic cardiomyopathy showed a relative risk of 2.79 (p=0.0594), although it was not significant in univariate CONCLUSIONS Chronic Cp infection, as expressed through a high IgA level, seems to have adverse impact on the survival rate in one-year follow-up after OHT. IgA titers against Cp in heart transplant recipients should therefore be assessed, as the high values might be a predictive risk factor within the first post-operative year.
Treatment of Inflammatory Facial Acne Vulgaris with Intense Pulsed Light and Short Contact of Topical 5‐Aminolevulinic Acid: A Pilot Study

BACKGROUND Photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) and red light (550–700 nm) has been introduced for effective treatment of facial acne. Untoward side effects are common, however. OBJECTIVE To evaluate the efficacy and safety of the short contact of topical ALA and intense pulsed light (IPL) in treatment of inflammatory facial acne. METHODS Fourteen patients with inflammatory facial acne were treated with IPL on the left side and combination of IPL and topical ALA on the right side at 3- to 4-week intervals for three sessions. Clinical photographs and lesion counts were obtained for evaluation. RESULTS All patients revealed a reduction in number of acne lesions on both sides. On the ALA-pretreated side, lesion counts decreased 87.7% at 12 weeks after the last treatment (p<.01). Meanwhile, lesion counts on the nonpretreated side decreased 66.8% (p<.01). In addition, a number of lesion counts on the ALA-pretreated side decreased. Mild edema and minimal crust developed on the combined-treatment side. CONCLUSION Short contact of topical ALA and IPL or IPL alone showed some beneficial effect in treatment of inflammatory facial acne; however, degree of improvement was better and remained longer with the combined regimen. Side effects were mild and reversible.