Miracle-dz/UniFAR-FTUs huggingface dataset:
Genome analysis of the staphylococcal temperate phage DW2 and functional studies on the endolysin and tail hydrolase

This study describes the genome of temperate Siphoviridae phage DW2, which is routinely propagated on Staphylococcus aureus DPC5246. The 41941 bp genome revealed an open reading frame (ORF1) which has a high level of homology with members of the resolvase subfamily of site-specific serine recombinase, involved in chromosomal integration and excision. In contrast, the majority of staphylococcal phages reported to date encode tyrosine recombinases. Two putative genes encoded by phage DW2 (ORF15 and ORF24) were highly homologous to the NWMN0273 and NWMN0280 genes encoding virulence factors carried on the genome of ϕNM4, a prophage in the genome of S. aureus Newman. Phage DW2 also encodes proteins highly homologous to two well-characterized Staphylococcus aureus pathogenicity island derepressors encoded by the staphylococcal helper phage 80α indicating that it may similarly act as a helper phage for mobility of pathogenicity islands in S. aureus. This study also focused on the enzybiotic potential of phage DW2. The structure of the putative endolysin and tail hydrolase were investigated and used as the basis for a cloning strategy to create recombinant peptidoglycan hydrolyzing proteins. After overexpression in E. coli, four of these proteins (LysDW2, THDW2, CHAPE1-153, and CHAPE1-163) were demonstrated to have hydrolytic activity against peptidoglycan of S. aureus and thus represent novel candidates for exploitation as enzybiotics.
Detection System Using Flexible Differential Eddy Current Sensor for Non-destructive Testing

High pressure hydrogen cylinder is an important equipment for hydrogen storage and transportation. Regular nondestructive testing of aluminum liner microcracks of hydrogen cylinder is necessary to ensure the safe use of high-pressure hydrogen cylinder. Due to the small volume and narrow mouth of the hydrogen storage bottle, the traditional detection methods are difficult to implement, so a detection system suitable for the detection of the inner surface of hydrogen cylinders is urgently needed. In this paper, a flexible differential eddy current sensor is designed based on the principle of eddy current testing. The feasibility of the sensor is verified by establishing a finite element model, and the influence of various parameters on the sensor response is analyzed. A scanning system suitable for the detection of the aluminum liner of hydrogen gas cylinders is designed. The scanning system can enter the interior of the aluminum liner of the hydrogen cylinder, and is equipped with an eddy current sensor to fit the inner surface of the aluminum liner for detection. The experimental results show that the sensor can suppress the common mode component in the signal, and has a high signal to noise ratio. What is more, the scanning system can complete the rapid scanning of the hydrogen cylinder liner, which verifies the feasibility of the detection system.
Differences by Race in the Health Status of Rural Cognitively Impaired Arkansans

Abstract Differences by Race in the Health Status of Rural Cognitively Impaired Arkansans Methods: Data collection involved telephone interviews with a random sample of 348 individuals who were 70 and older, had been screened for mild cognitive impairment and lived in one of the 64 Arkansas counties designated as nonmetropolitan Results: Multivariate analyses found that African American respondents had greater IADL disability, poorer self-rated health status, greater number of errors on the cognitive screener, and more chronic health conditions. Further multivariate analyses found that African American men and African Americans with less than a ninth grade education had poorer health status outcomes, except for ADL disability. Discussion: Clinicians and policy makers should consider racial discrepancies in functional health status in determining medical and social service needs for seniors who are cognitively impaired and reside in rural settings.
Preparation and Properties of Alkali Activated Metakaolin-Based Geopolymer

The effective activation and utilization of metakaolin as an alkali activated geopolymer precursor and its use in concrete surface protection is of great interest. In this paper, the formula of alkali activated metakaolin-based geopolymers was studied using an orthogonal experimental design. It was found that the optimal geopolymer was prepared with metakaolin, sodium hydroxide, sodium silicate and water, with the molar ratio of SiO2:Al2O3:Na2O:NaOH:H2O being 3.4:1.1:0.5:1.0:11.8. X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR) were adopted to investigate the influence of curing conditions on the mechanical properties and microstructures of the geopolymers. The best curing condition was 60 °C for 168 h, and this alkali activated metakaolin-based geopolymer showed the highest compression strength at 52.26 MPa. In addition, hollow micro-sphere glass beads were mixed with metakaolin particles to improve the thermal insulation properties of the alkali activated metakaolin-based geopolymer. These results suggest that a suitable volume ratio of metakaolin to hollow micro-sphere glass beads in alkali activated metakaolin-based geopolymers was 6:1, which achieved a thermal conductivity of 0.37 W/mK and compressive strength of 50 MPa. By adjusting to a milder curing condition, as-prepared alkali activated metakaolin-based geopolymers could find widespread applications in concrete thermal protection.
Prothrombin complex concentrate safely reverses warfarin-related bleeding

Commentary on: Hickey M, Gatien M, Taljaard M, et al. Outcomes of urgent warfarin reversal with frozen plasma versus prothrombin complex concentrate in the emergency department. Circulation 2013;128:360–4. [OpenUrl][1][Abstract/FREE Full Text][2] The incidence of major bleeding among patients receiving warfarin ranges from 1.35% to 3.4%, and intracranial haemorrhage (ICH) occurs in up to 0.7% of cases/annum.1 Therefore, effective strategies for warfarin reversal in patients with major bleeding are important. Historically, only fresh frozen plasma (FFP) and intravenous vitamin K1 have been available for emergency reversal, neither of which immediately restores vitamin K-dependent coagulation factors.2 FFP administration is often associated with lengthy delays and well-described potential risks. Prothrombin complex concentrates (PCC) are plasma derived, virally inactivated clotting factors that can be used for reversing warfarin coagulopathy. They can broadly … [1]: {openurl}? query=rft.jtitle%253DCirculation%26rft_id%253Dinfo%253Adoi%252F10.1161%252FCIRCULATIONAHA.113. 001875%26rft_id%253Dinfo%253Apmid%252F23770745%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink? linkType=ABST&journalCode=circulationaha&resid=128/4/360&atom=%2Febmed%2F19%2F2%2F75.atom
Oxygen distribution and consumption in the macaque retina.

The oxygen distribution in the retina of six anesthetized macaques was investigated as a model for retinal oxygenation in the human retina in and adjacent to the fovea. P(O2) was measured as a function of retinal depth under normal physiological conditions in light and dark adaptation with O(2) microelectrodes. Oxygen consumption (Q(O2)) of the photoreceptors was extracted by fitting a steady-state diffusion model to P(O2) measurements. In the perifovea, the P(O2) was 48 +/- 13 mmHg (mean and SD) at the choroid and fell to a minimum of 3.8 +/- 1.9 mmHg around the photoreceptor inner segments in dark adaptation, rising again toward the inner retina. The P(O2) in the inner half of the retina in darkness was 17.9 +/- 7.8 mmHg. When averaged over the outer retina, photoreceptor Q(O2) (called Q(av)) was 4.6 +/- 2.3 ml O(2). 100 g(-1). min(-1) under dark-adapted conditions. Illumination sufficient to saturate the rods reduced Q(av) to 72 +/- 11% of the dark-adapted value. Both perifoveal and foveal photoreceptors received most of their O(2) from the choroidal circulation. While foveal photoreceptors have more mitochondria, the Q(O2) of photoreceptors in the fovea was 68% of that in the perifovea. Oxygenation in macaque retina was similar to that previously found in cats and other mammals, reinforcing the relevance of nonprimate animal models for the study of retinal oxygenation, but there was a smaller reduction in Q(O2) with light than observed in cats, which may have implications for understanding the influence of light under some clinical conditions.
Albuminated dacron protheses as improved blood vessel substitutes.

An improved vascular graft was achieved by treating knitted Dacron prostheses with cross-linked albumin. Eight segments, each six centimeters in length, were coated and implanted in the canine thoracic aorta for periods ranging from 24 hours to six months. The results were compared with the eight untreated grafts implanted for similar periods as control experiments. Albumin coating resulted in a faster healing : cells appeared earlier and collagen development was greater. The most beneficial effect of that treatment was the reduction in embolization, as shown by the considerable decrease in kidney damage.
Book Review: How and How Not to Write on a “Legendary” Philosopher

The author argues that Fuller’s book, with the single exception of its correct reinterpretation of Kuhn as no apostle of postmodernism—such that his “fans” and “foes” alike are boxing with (or cheering on) only a shadow Kuhn—is worse than worthless. For, in a disreputable and outright propagandistic fashion, it consists in a series of serious distortions of and outright falsehoods about Kuhn and recent philosophy of science, distortions and falsehoods which may well mislead the unwary reader. Nickles’ s collection by contrast is a competent, useful, and workmanlike performance, although the author argues that the editor’s focus on cognitive science uses of Kuhn (and of Wittgenstein) is unhelpful, in that these uses again distort the philosophy of Kuhn (as of Wittgenstein), who was on balance no apostle of cognitive science either.
Matching network absorption in ladder electroacoustic filters

This paper explores a synthesis approach to integrate the lumped elements of the input and output matching networks within the electroacoustic filter structure itself directly during the synthesis process. This integration allows for the removal of external matching components while preserving the necessary impedance matching conditions at both the input and output interfaces, thereby improving the efficiency and practicality of filter network designs.
Revision Total Knee Arthroplasty with a Cemented Posterior Stabilized, Condylar Constrained or Fully Constrained Prosthesis: A Minimum 2-year Follow-up Analysis

Background The clinical and radiological outcomes of revision total knee arthroplasty with a cemented posterior stabilized (PS), condylar constrained knee (CCK) or a fully constrained rotating hinge knee (RHK) prosthesis were evaluated. Methods This study reviewed the clinical and radiological results of 36 revision total knee arthroplasties with a cemented PS, CCK, and RHK prosthesis in 8, 25, and 13 cases, respectively, performed between 1998 and 2006. The mean follow-up period was 30 months (range, 24 to 100 months). The reason for the revision was aseptic loosening of one or both components in 15, an infected total knee in 18 and a periprosthetic fracture in 3 knees. The average age of the patients at the time of the revision was 65 years (range, 58 to 83 years). The original diagnosis for all primary total knee arthroplasties was osteoarthritis except for one case of a Charcot joint. All revision prostheses were fixed with cement. The bone deficiencies were grafted with a cancellous allograft in the contained defect and cortical allograft fixed with a plate and screws in the noncontained defect. A medial gastrocnemius flap was needed to cover the wound dehiscence in 6 of the 18 infected cases. Results The mean Knee Society knee score improved from 28 (range, 5 to 43) to 83 (range, 55 to 94), (p < 0.001) and the mean Knee Society function score improved from 42 (range, 10 to 66) to 82 (range, 60 to 95), (p < 0.001) at the final follow-up. Good or excellent outcomes were obtained in 82% of knees. There were 5 complications (an extensor mechanism rupture in 3 and recurrence of infection in 2 cases). Three cases of an extensor mechanism defect (two ruptures of ligamentum patellae and one patellectomy) were managed by the RHK prosthesis to provide locking stability in the heel strike and push off phases, and two cases of recurrent infection used an antibiotic impregnated cement spacer. The radiological tibiofemoral alignment improved from 1.7° varus to 3.0° valgus in average. Radiolucent lines were observed in 18% of the knees without progressive osteolysis. Conclusions Revision total knee requires a more constrained prosthesis than primary total knee arthroplasty because of the ligamentous instability and bony defect. This short to midterm follow-up analysis demonstrated that a well planned and precisely executed revision can reduce pain and improve the knee function significantly. Infected cases showed as good a result as those with aseptic loosening through the use of antibiotics-impregnated cement beads and proper soft tissue coverage with a medial gastrocnemius flap.
Secure Multi-Keyword Retrieval with Integrity Guarantee for Outsourced ADS-B Data in Clouds

With the development of Automatic Dependent Surveillance-Broadcast (ADS-B) technology in the aviation industry, a large amount of data are generated in ADS-B systems everyday. Cloud storage can satisfy the requirement of storing a large amount of ADS-B data well, however, the data stored on cloud server also raises problems about the security and confidentiality. This paper proposes a secure ADS-B data outsourcing scheme with integrity guarantee and multi-keyword retrieval (MRDP) to address these issues. In our MRDP, an index is generated for each piece of ADS-B data through Bloom filters to enable multi-keyword retrieval from clouds. Also, a unique label is produced for each piece of ADS-B data for integrity verification of query results. Our MRDP solution enjoys completeness property in that all query results with regard to the multiple keywords would be returned by the cloud server, otherwise it could be detected by the user. Security analysis indicated that our scheme offers integrity, completeness and privacy protection on outsourced ADS-B data, under the computational Diffie-Hellman (CDH) assumption and the discrete logarithm (DL) assumption. Theoretical and experimental analyses demonstrate the practicality of our proposed MRDP construction compared to existing solutions.
Neglect dyslexia for numbers? a case report

Abstract We report the case study of a patient (YM) with a specific number reading deficit, but with fairly preserved number comprehension and calculation. YM exhibits a spatial error pattern akin to neglect dyslexia, making most of his reading errors and perseverations on the leftmost digit of any number. This and a strong effect of visual similarity on errors suggest a visual deficit. Yet number syntax is preserved: most productions are legal number names, and less errors are observed on digits 0 and 1 when they bear a silent or syntactic role. On the basis of a detailed account of the deficit, we propose a revision of McCloskey, Sokol, and Goodman's (1986) model of number reading. We further discuss the apparent contradiction between the symbolic and the spatial aspects of YM's reading deficit, and the adequacy of the concept of neglect dyslexia.
Comment on Fraser and Gordon's "A Genealogy of Dependency: Tracing a Keyword of the U.S. Welfare State"

iN ANCY FRASER AND Linda Gordon's article in a 1994 issue of Signs, "A Genealogy of Dependency: Tracing a Keyword of the U.S. Welfare State," is an important contribution to the burgeoning literature on gender and the welfare state. The authors achieve their goals of unpacking the dense network of meanings associated with the term dependency and defamiliarizing the reader with a word that is invoked in policy debates with increasing frequency. Their descriptions of the changing textures of the words dependency and independence are rich and nuanced-providing the basis for a fresh analysis of the politics of welfare in the United States. In particular, their comparison of the image of the welfare mother of the 1960s with that of this latest round of the welfare backlash illuminates a number of consequential-if subtle-shifts in the discourse of domination. The work is significant in both a scholarly and political sense. First, students of the American welfare state-though increasingly sensitive to "gender subtexts"-have only recently begun to recognize the salience of the discourses of (in)dependence that suffuse those subtexts. New research on German, Dutch, and Australian welfare states indicates that a close reading of the politics of (in)dependence can be a fruitful analytic strategy in revealing the gendered core of many instruments of state intervention.1 In their analysis of the American case, Fraser and Gordon's claim that the discourses of (in)dependence have not merely described but have helped construct the welfare state is convincing.
Modularization of Crowdfunding Services - Designing Disruptive Innovations in the Banking Industry

Crowdfunding represents a disruptive innovation in the banking industry by enabling the exploitation of market segments. Incumbents struggle to utilize this new phenomenon as crowdfunding is based on modules that have not been considered relevant for banking so far. Nevertheless, crowdfunding services are not entirely new compared to traditional banking. We argue that the modular design enables a bank to utilize crowdfunding. Thus, we started an action research project in order to investigate how modularization enables a bank to design crowdfunding services. Findings so far led to the identification of eleven preliminary crowdfunding services and their interconnection within an ecosystem. Our expected contribution will increase the understanding of crowdfunding services by bridging research on modularization, service ecosystems, and crowdfunding, and highlight the handling of disruptive innovations in an established industry. For practice, we provide a way of designing crowdfunding services in an efficient manner while building on already existing competencies.
Locus of Control as a Personality Correlate of Materialism: An Empirical Note

For a sample of 148 undergraduate students, scores on Belk's materialism scale correlated negatively with Rotter's locus-of-control scores. Stepwise regression further indicates that Rotter scores are responsive largely to the envy subscale of materialism, with the possessiveness and nongenerosity subscales contributing little to the explained variance. Inasmuch as composite materialism (the sum of three subscales) relates inversely with internal locus of control, this result is consistent with the other/external-directed nature of envy and the self/internal-directed focus of possessiveness and nongenerosity.
O of the Glacial Deep Ocean

We use pore fluid measurements of the chloride concentration and the oxygen isotopic composition from Ocean Drilling Program cores to reconstruct salinity and temperature of the deep ocean during the Last Glacial Maximum (LGM). Our data show that the temperatures of the deep Pacific, Southern, and Atlantic oceans during the LGM were relatively homogeneous and within error of the freezing point of seawater at the ocean's surface. Our chloride data show that the glacial stratification was dominated by salinity variations, in contrast with the modern ocean, for which temperature plays a primary role. During the LGM the Southern Ocean contained the saltiest water in the deep ocean. This reversal of the modern salinity contrast between the North and South Atlantic implies that the freshwater budget at the poles must have been quite different. A strict conversion of mean salinity at the LGM to equivalent sea-level change yields a value in excess of 140 meters. However, the storage of fresh water in ice shelves and/or groundwater reserves implies that glacial salinity is a poor predictor of mean sea level. The general circulation of the modern deep ocean is dominated by two distinct water masses: In the Atlantic, warm, salty North Atlantic Deep Water (NADW) is formed north of Iceland and in the Labrador Sea, whereas in the Southern Ocean, cold, fresh Antarctic Bottom Water (AABW) forms on continental shelves. Because of its greater density, AABW underlies NADW in the Atlantic at all latitudes south of ϳ40°N. No deep waters are formed in the North Indian or North Pacific Oceans today. The mean deep-ocean tracer properties are strongly weighted toward those of the Indo-Pacific abyss, where deep waters are roughly a 50/50 mixture of AABW and NADW (1) and the average overturning time is about 800 years (2). Measurements of passive tracer fields (3– 5) and the radiocarbon age difference between surface and deep waters (6 –9) suggest that during the LGM the Atlantic was flooded by waters of a Southern Ocean origin, the LGM analog to NADW shoaled but still exited the Atlantic, and the mean overturning rate was somewhat slower than today. These changing patterns of deep tracer distributions are consistent over many glacial cycles (10). Although these tracer distributions for the LGM have provided significant insight into the mechanisms of climate change, a better understanding of the deep circulation of the past requires constraints on the seawater density , …
Pragmatics of Sibling Speech to One Year Olds.

TOMASELLO, MICHAEL, and MANNLE, SARA. Pragmatics of Sibling Speech to One-Year-Olds. CHILD DEVELOPMENT, 1985, 56, 911-917. Very little research to date has been concerned with characterizing the nature or the effect of the linguistic interactions between beginning language learners and their older siblings. Although it has been suggested that 3-5-year-old preschoolers do adjust structural characteristics of their speech for infants, there are indications that they may not make adjustments in the pragmatic domain. The current study, therefore, was designed to explore sibling-infant linguistic interaction with a special emphasis on pragmatic factors. 10 infants were videotaped twice, once at 12-18 months and once at 18-24 months, in free play with their mothers and with their preschool-age siblings. Compared to mothers, siblings were highly directive in their linguistic interactions and showed little inclination to provide the infant with nonverbal information. They did not adjust the length and complexity of their utterances over time, as did the mothers. Conversations between siblings and infants were short or nonexistent and contained few of the conversationmaintaining devices that mothers used. The directiveness of siblings and their nonresponsiveness in conversations may contribute to the tendency of some later-borns to employ expressive styles of language acquisition.