Miracle-dz/UniFAR-FTUs huggingface dataset:
Cultural expressions of depression and the development of the Indonesian Depression Checklist

Depression may manifest differently across cultural settings, suggesting the value of an assessment tool that is sensitive enough to capture these variations. The study reported in this article aimed to develop a depression screening tool for Indonesians derived from ethnographic interviews with 20 people who had been diagnosed as having depression by clinical psychologists at primary health centers. The tool, which we have termed the Indonesian Depression Checklist (IDC), consists of 40 items. The tool was administered to 125 people assessed to have depression by 40 clinical psychologists in primary health centers. The data were analyzed with Confirmatory Factor Analysis (CFA) (IBM SPSS AMOS Software). CFA identified a five-factor hierarchical model (χ 2 = 168.157, p = .091; CFI = .963; TLI = .957; RMSEA = .036). A 19-item inventory of the IDC, with five factors – Physical Symptoms, Affect, Cognition, Social Engagement and Religiosity – was identified. There was a strong correlation between the total score of the IDC and total score of the Center for Epidemiological Studies-Depression scale (revised version CES-D), a standard tool for assessing symptoms of depression. The IDC accommodates culturally distinctive aspects of depression among Indonesians that are not included in the CES-D.
Dielectric and thermodynamic response of a generalized reaction field model for liquid state simulations

A generalized reaction field (GRF) model for simulations of liquid water is presented. The method is based on the solution of the Poisson equation for the reaction field acting on a collection of charges in a spherical cavity which is immersed in a continuum dielectric medium. In this model, the reaction field potential arising from the charges in the spherical cavity can be expressed as an infinite series, each term of which is the reaction field arising from a corresponding multipole in the expansion of the charge distribution. The GRF model is used here in simulations of liquid water and of solutions containing one or two ions in water. The dielectric constant computed for liquid water with the generalized reaction field agrees with previous results obtained using the conventional dipolar reaction field. The water orientational correlation functions converge to within 5% of the correct value when the first three terms are included in the multipolar expansion of the reaction field. Thermodynamic results.
Protocol and Tools for Conducting Agile Software Engineering Research in an Industrial-Academic Setting: A Preliminary Study

Conducting empirical research in software engineering industry is a process, and as such, it should be generalizable. The aim of this paper is to discuss how academic researchers may address some of the challenges they encounter during conducting empirical research in the software industry by means of a systematic and structured approach. The protocol developed in this paper should serve as a practical guide for researchers and help them with conducting empirical research in this complex environment.
Improved oxygen systems in district hospitals in Lao PDR: a prospective field trial of the impact on outcomes for childhood pneumonia and equipment sustainability

Background Hypoxaemia is a common and potentially fatal complication of many childhood, newborn and maternal conditions but often not well recognised or managed in settings where resources are limited. Oxygen itself is often inaccessible due to cost or logistics. This paper describes implementation of oxygen systems in Lao district hospitals, clinical outcomes after 24 months and equipment outcomes after 40 months postimplementation. Methods A prospective field trial was conducted in 20 district hospitals, including 10 intervention hospitals that received oxygen concentrators and 10 control hospitals. Equipment outcomes were evaluated at baseline, 12, 24 and 40 months. Clinical outcomes of children under 5 years of age with pneumonia were evaluated using a before-and-after controlled study design with information retrospectively collected from medical records. Results Fourteen (37%), 7 (18%) and 12 (34%) of 38 concentrators required repair at 12, 24 and 40 months, respectively. The proportion of children discharged well increased in intervention (90% (641/712) to 95.2% (658/691)) and control hospitals (87.1% (621/713) to 92.1% (588/606)). In intervention hospitals, case fatality rates for childhood pneumonia fell from 2.7% (19/712) preintervention to 0.80% (6/691) postintervention with no change in control hospitals (1.7% (12/713) preintervention and 2.3% (14/606) postintervention). Conclusion Medium-term sustainability of oxygen concentrators in hospitals accompanied by reduced case fatality for childhood pneumonia has been demonstrated in Lao PDR. Significant local engineering capacity to address multiple causes of equipment malfunction was critical. The ongoing requirements and fragile structures within the health system remain major risks to long-term sustainability.
Foaming in anaerobic digesters ― a survey and laboratory investigation

Anaerobic digestion for sludge stabilization is widely used in the wastewater treatment industry. One of the most common operating problems is foaming that can result in unsightly foam penetration between floating digester covers and the digester wall? exposed foam also can be a potential odor problem; en trapment in and fouling of gas collection pipework, gas com pressors, and gas recirculation pipework; inversion of solids pro files in the digester with thick solids at the top and dilute solids at the bottom; and gas binding of sludge recirculation pumps. Despite its widespread occurrence, foaming in anaerobic digesters has not been the subject of intense investigation and the literature on the subject is scant and contradictory.
On the complexity of parallel coordinate descent

In this work we study the parallel coordinate descent method (PCDM) proposed by Richtárik and Takáč [Parallel coordinate descent methods for big data optimization, Math. Program. Ser. A (2015), pp. 1–52] for minimizing a regularized convex function. We adopt elements from the work of Lu and Xiao [On the complexity analysis of randomized block-coordinate descent methods, Math. Program. Ser. A 152(1–2) (2015), pp. 615–642], and combine them with several new insights, to obtain sharper iteration complexity results for PCDM than those presented in [Richtárik and Takáč, Parallel coordinate descent methods for big data optimization, Math. Program. Ser. A (2015), pp. 1–52]. Moreover, we show that PCDM is monotonic in expectation, which was not confirmed in [Richtárik and Takáč, Parallel coordinate descent methods for big data optimization, Math. Program. Ser. A (2015), pp. 1–52], and we also derive the first high probability iteration complexity result where the initial levelset is unbounded.
Groundwater Modeling with Nonlinear Uncertainty Analyses to Enhance Remediation Design Confidence

Soil and groundwater contamination are often managed by establishing on‐site cleanup targets within the context of risk assessment or risk management measures. Decision‐makers rely on modeling tools to provide insight; however, it is recognized that all models are subject to uncertainty. This case study compares suggested remediation requirements using a site‐specific numerical model and a standardized analytical tool to evaluate risk to a downgradient wetland receptor posed by on‐site chloride impacts. The base case model, calibrated to observed non‐pumping and pumping conditions, predicts a peak concentration well above regulatory criteria. Remediation scenarios are iteratively evaluated to determine a remediation design that adheres to practical site constraints, while minimizing the potential for risk to the downgradient receptor. A nonlinear uncertainty analysis is applied to each remediation scenario to stochastically evaluate the risk and find a solution that meets the site‐owner risk tolerance, which in this case required a risk‐averse solution. This approach, which couples nonlinear uncertainty analysis with a site‐specific numerical model provides an enhanced level of knowledge to foster informed decision‐making (i.e., risk‐of‐success) and also increases stakeholder confidence in the remediation design.
FBXW7 deletion contributes to lung tumor development and confers resistance to gefitinib therapy

Gefitinib, an epidermal growth factor receptor–tyrosine kinase inhibitor (EGFR‐TKI), is an effective treatment for non‐small‐cell lung cancer (NSCLC) with EGFR activating mutations, but inevitably, the clinical efficacy is impeded by the emergence of acquired resistance. The tumor suppressor gene FBXW7 modulates chemosensitivity in various human cancers. However, its role in EGFR‐TKI therapy in NSCLC has not been well studied. Here, we demonstrate that the mice with deficient Fbxw7 have greater susceptibility to urethane‐induced lung tumor development. Through analysis of The Cancer Genome Atlas data, we show that deletion of FBXW7 occurs in 30.9% of lung adenocarcinomas and 63.5% of lung squamous cell carcinomas, which significantly leads to decrease in FBXW7 mRNA expression. The reduction in FBXW7 mRNA level is associated with poor overall survival in lung cancer patients. FBXW7 knockdown dramatically promotes epithelial–mesenchymal transition, migration, and invasion in NSCLC cells. Moreover, with silenced FBXW7, EGFR‐TKI‐sensitive cells become resistant to gefitinib, which is reversed by the mammalian target of rapamycin inhibitor, rapamycin. Furthermore, xenograft mouse model studies show that FBXW7 knockdown enhances tumorigenesis and resistance to gefitinib. Combination of gefitinib with rapamycin treatment suppresses tumor formation of gefitinib‐resistant (GR) FBXW7‐knockdown cells. In conclusion, our findings suggest that loss of FBXW7 promotes NSCLC progression as well as gefitinib resistance and combination of gefitinib and rapamycin may provide an effective therapy for GR NSCLC.
Scaling up cancer care in the WHO Eastern Mediterranean Region.

PDF version Commentary Gemma Lyons1, Rengaswamy Sankaranarayanan2, Anthony B Millar3 and Slim Slama1 1WHO Regional Office for the Eastern Mediterranean, Cairo, Egypt (Correspondence to: Slim Slama: slamas@who.int) 2WHO International Agency for Research on Cancer, Lyon, France 3University of Toronto, Toronto, Canada.
CHARACTERIZATION OF PERFORMANCE OF PAPER-OIL INSULATION SYSTEM IN THE PRESENCE OF DBDS

Premature death of power and converter transformers as a result of formation of Corrosive elements on copper conductors due to sulpher in transformer oil is a serious phenomenon that is haunting power industry over the years. Addition of Dibenzyl disulphide (DBDS) by the manufacturers of transformer oil, so as to increase the performance characteristics of transformer oil is one of the reasons for formation of copper sulphide. Copper sulphide being conductive, affects the voltage distribution due to surface discharges. The insulation is damaged due to these discharges and leads to the breakdown of insulation. In the present work experimental analysis has been carried out to investigate the role of DBDS in increasing the discharge activity and thus reduction in breakdown strength of transformer insulation.
Tillage Effects on Soil in Southern Guatemala: A case study using remote analyses

Guatemala lacks soils information, yet soils knowledge is essential in order to reduce environmental impacts, improve food security, determine best farming practices, and increase crop yields(Karlen et al., 1994). Reasons for the lack of information include lack of personnel and difficulty accessing equipment. This study's objective is to remedy those shortcomings via (a) the creation and sending of a soil testing kit, (b) corresponding manual written for non-soil scientist use, and (c) mechanisms to send data to ISU for thorough analysis. The soil testing kit included basic laboratory materials used to test essential soil characteristics such as soil aggregate stability, aggregate size, pH, color, and structure. The field site is an experimental farm owned by the non-profit sustainable agriculture organization, Semilla Nueva. Semilla Nueva has overseen a tillage experiment from 2013 to the present but has not collected soil health data. The present study utilized established experimental plots already subjected to three different management treatments (no-till, tilled, and burned) in order to better understand how different tillage practices affect soil health characteristics in this region. Preliminary results suggest that soil aggregate stability, pH, exchange capacity, and soil structure grade were all negatively impacted by tillage and plant residue burning.
DeepMarks: A Digital Fingerprinting Framework for Deep Neural Networks

This paper proposes DeepMarks, a novel end-to-end framework for systematic fingerprinting in the context of Deep Learning (DL). Remarkable progress has been made in the area of deep learning. Sharing the trained DL models has become a trend that is ubiquitous in various fields ranging from biomedical diagnosis to stock prediction. As the availability and popularity of pre-trained models are increasing, it is critical to protect the Intellectual Property (IP) of the model owner. DeepMarks introduces the first fingerprinting methodology that enables the model owner to embed unique fingerprints within the parameters (weights) of her model and later identify undesired usages of her distributed models. The proposed framework embeds the fingerprints in the Probability Density Function (pdf) of trainable weights by leveraging the extra capacity available in contemporary DL models. DeepMarks is robust against fingerprints collusion as well as network transformation attacks, including model compression and model fine-tuning. Extensive proof-of-concept evaluations on MNIST and CIFAR10 datasets, as well as a wide variety of deep neural networks architectures such as Wide Residual Networks (WRNs) and Convolutional Neural Networks (CNNs), corroborate the effectiveness and robustness of DeepMarks framework.
Giant-Cell Tumour of Bone

benign or malignant, and if in some cases benign and in others malignant, how is the distinction to be made so that a clear guide to treatment may be laid down ? If on the other hand, as is widely believed, the condition is merely an Unusual reaction in bone to trauma or some ill-defined stimulus, Possibly in association with a generalised skeletal dystrophy, how should it be treated ? It is interesting and also disturbing to think that the difficulties which became evident to the surgeon and pathologist very soon after the so-called tumour was described are still puzzling both types of worker. The names which have been given to the condition illustrate concisely the varying views which have been held regarding its nature. Thus it has been called tumeur a myeloplaxes,
Drosophila Glypicans Regulate Follicle Stem Cell Maintenance and Niche Competition

Adult stem cells reside in specialized microenvironments called niches, which provide signals for stem cells to maintain their undifferentiated and self-renewing state. To maintain stem cell quality, several types of stem cells are known to be regularly replaced by progenitor cells through niche competition. However, the cellular and molecular bases for stem cell competition for niche occupancy are largely unknown. Here, we show that two Drosophila members of the glypican family of heparan sulfate proteoglycans (HSPGs), Dally and Dally-like (Dlp), differentially regulate follicle stem cell (FSC) maintenance and competitiveness for niche occupancy. Lineage analyses of glypican mutant FSC clones showed that dally is essential for normal FSC maintenance. In contrast, dlp is a hypercompetitive mutation: dlp mutant FSC progenitors often eventually occupy the entire epithelial sheet. RNA interference knockdown experiments showed that Dally and Dlp play both partially redundant and distinct roles in regulating Jak/Stat, Wg, and Hh signaling in FSCs. The Drosophila FSC system offers a powerful genetic model to study the mechanisms by which HSPGs exert specific functions in stem cell replacement and competition.
The Functions of the Brain

Volume 1. Introduction Nick Wade Containing the Nervous System [1803] Idea of a New Anatomy of the Brain [1811], both by Charles Bell Volume 2. Dr F.J. Gall's System of the Functions of the Brain, extracted from C.A. Blode's account of Dr Gall's lectures, held on the above [sic] subject at Dresden [1807] Carl August Blode Phrenology Examined [1846] Pierre Flourens Volumes 3. and 4. Elements of Physiology [1840, 1843] Johannes Mueller, translated by W. Baly Volume 5. Mind and Body. The Theories of their Relation [1873] Alexander Bain Volume 6. Lectures on the Localization of Cerebral and Spinal Diseases [1883] Jean Martin Charcot, translated by W.B. Hadden Volume 7. The Functions of the Brain [2nd ed. 1886] David Ferrier Volume 8. The Integrative Action of the Nervous System [1906] Charles S. Sherrington
Minimax rates for cost-sensitive learning on manifolds with approximate nearest neighbours

We study the approximate nearest neighbour method for cost-sensitive classification on low-dimensional manifolds embedded within a high-dimensional feature space. We determine the minimax learning rates for distributions on a smooth manifold, in a cost-sensitive setting. This generalises a classic result of Audibert and Tsybakov. Building upon recent work of Chaudhuri and Dasgupta we prove that these minimax rates are attained by the approximate nearest neighbour algorithm, where neighbours are computed in a randomly projected low-dimensional space. In addition, we give a bound on the number of dimensions required for the projection which depends solely upon the reach and dimension of the manifold, combined with the regularity of the marginal.
Sequence and Expression of Complement Factor H Gene Cluster Variants and Their Roles in Age-Related Macular Degeneration Risk

Purpose To investigate how potentially functional genetic variants are coinherited on each of four common complement factor H (CFH) and CFH-related gene haplotypes and to measure expression of these genes in eye and liver tissues. Methods We sequenced the CFH region in four individuals (one homozygote for each of four common CFH region haplotypes) to identify all genetic variants. We studied associations between the haplotypes and AMD phenotypes in 2157 cases and 1150 controls. We examined RNA-seq profiles in macular and peripheral retina and retinal pigment epithelium/choroid/sclera (RCS) from eight eye donors and three liver samples. Results The haplotypic coinheritance of potentially functional variants (including missense variants, novel splice sites, and the CFHR3–CFHR1 deletion) was described for the four common haplotypes. Expression of the short and long CFH transcripts differed markedly between the retina and liver. We found no expression of any of the five CFH-related genes in the retina or RCS, in contrast to the liver, which is the main source of the circulating proteins. Conclusions We identified all genetic variants on common CFH region haplotypes and described their coinheritance. Understanding their functional effects will be key to developing and stratifying AMD therapies. The small scale of our expression study prevented us from investigating the relationships between CFH region haplotypes and their expression, and it will take time and collaboration to develop epidemiologic-scale studies. However, the striking difference between systemic and ocular expression of complement regulators shown in this study suggests important implications for the development of intraocular and systemic treatments.
Pore-scale contact angle measurements of CO2–brine–glass beads system using micro-focused X-ray computed tomography

Conventional methods for measuring contact angle are usually applied on smooth surfaces. Methods concerning contact angle determinations performed directly on pore surfaces of porous media have rarely been reported. This work approaches the pore-scale measurement of local contact angle in a CO2–brine–glass beads system, using micro-focused X-ray computed tomography (micro-CT). Both drainage and imbibition experiments with 0.1 ml/min injection rate were conducted at 40°C and 8 MPa. The effectiveness of this pore-scale approach is confirmed by comparing the results with the results gathered from traditional sessile drop methodology. Observations indicate that the contact angle hysteresis phenomenon was not so obvious for intermediate-wet glass beads in the employed experimental setting. In real reservoir circumstances, the roughness and capillary variation caused significant deviations in contact angle distribution for both drainage and imbibition, even in rock cores consisting of a single-phase material.
Scrum2Kanban: Integrating Kanban and Scrum in a University Software Engineering Capstone Course

Using university capstone courses to teach agile software development methodologies has become commonplace, as agile methods have gained support in professional software development. This usually means students are introduced to and work with the currently most popular agile methodology: Scrum. However, as the agile methods employed in the industry change and are adapted to different contexts, university courses must follow suit. A prime example of this is the Kanban method, which has recently gathered attention in the industry. In this paper, we describe a capstone course design, which adds the hands-on learning of the lean principles advocated by Kanban into a capstone project run with Scrum. This both ensures that students are aware of recent process frameworks and ideas as well as gain a more thorough overview of how agile methods can be employed in practice. We describe the details of the course and analyze the participating students' perceptions as well as our observations. We analyze the development artifacts, created by students during the course in respect to the two different development methodologies. We further present a summary of the lessons learned as well as recommendations for future similar courses. The survey conducted at the end of the course revealed an overwhelmingly positive attitude of students towards the integration of Kanban into the course.