Miracle-dz/UniFAR-FTUs huggingface dataset:
Geology and mineralogical zonation of the Olympic Dam Iron Oxide Cu-U-Au-Ag deposit, South Australia

Olympic Dam is a supergiant Fe oxide Cu-U-Au-Ag deposit that is also strongly enriched in a wide range of elements, including F, S, C, As, Ba, Bi, Cd, Co, Cr, Fe, In, Mo, Nb, Ni, P, Pb, Sb, Se, Sn, Sr, Te, V, W, Y, Zn, and rare earth elements (REE). The deposit contains more than 90 minerals. Mineralization was associated with intense, texturally destructive hematite and sericite alteration and brecciation of the primary host rock units, including Roxby Downs Granite, bedded clastic facies rocks, and mafic-ultramafic dikes. Based on comprehensive geological, geochemical, and mineralogical data sets collected during a deposit-scale resource delineation and sterilization drilling program (2003–2008), compiled with historical geological data and interpretations, we quantify geochemical and mineralogical associations and distribution patterns. The granite-derived elements (Al, Be, Ca, Hf, K, Li, Mg, Mn, Na, Rb, Si, Th, Ti, and Zr) are negatively correlated with Fe, whereas the hydrothermal elements (Ag, As, Au, Ba, Bi, Cd, Co, CO2, Cr, Cu, F, Fe, In, Mo, Nb, Ni, P, Pb, S, Sb, Se, Sn, Sr, Te, U, V, W, Y, Zn, and REE) are positively correlated; the ore and gangue minerals are also correlated with Fe abundance. There is a strong spatial association of Cu, U3O8, Au, and Ag. From the periphery inward and upward from depth toward the deposit center, the most significant zones are as follows: (1) reduced Fe oxide alteration (magnetite-apatite-siderite-chlorite-quartz) → oxidized Fe oxide alteration (hematite-sericite-fluorite) → hematite-quartz-barite alteration, (2) siderite → fluorite → barite, (3) sphalerite → galena → pyrite → chalcopyrite → bornite → chalcocite → nonsulfide, and (4) distal or paragenetically early (? ) base metal-poor (Mo-W-Sn-As-Sb) → base metal-rich (Cu-Pb-Zn) minerals → sulfide-barren hematite-quartz-barite breccia in the deposit center. Spatially isolated remnants of advanced argillic alteration (sericite + quartz ± Al-OH) have been defined for the first time. Progressive Fe oxide addition to, and sericite replacement of the primary host rocks produced distinctive, albeit complex, hydrothermally altered and mineralized zones in the Olympic Dam deposit.
Sex differences in a murine model of asthma are time and tissue compartment dependent

Asthma is a sexually dimorphic disease with greater documented prevalence and severity in women compared to men. Immunological parameters in mouse models of asthma also exhibit sexual dimorphism, with female mice typically having higher Th2 inflammation than male mice. Despite the standard choice of ovalbumin (OVA) murine models of asthma to study sex differences, there is little consensus across different studies in model design, timelines of sample collection and measured endpoints. To seek agreement in previous reports, we sought to resolve the time course of unfolding sex differences in a standardized 6-challenge OVA murine model of asthma. Immune responses in both lung tissue and airway compartments were quantified by multi-color flow cytometry. OVA-specific immunoglobulin E (IgE) and IgG1 were assayed by ELISA. Several lung tissue markers showed sexual dimorphism as measured by quantitative PCR (qPCR), including cytokines IL-4, IL-5, IL-13 and IL-10 and repair markers nestin and tenascin C. Although females had greater responses in the late phase of the model, male-biased dimorphism was evident in early responses. While females had greater adaptive responses (T and B cells) and higher eosinophils, male data suggested a stronger innate immune response (monocytes, neutrophils). Females had significantly higher OVA-specific IgE prior to the elicitation phase of the model, indicating early sex differences during sensitization. The same parameters frequently had opposing patterns of dimorphism in lung tissue vs. airway. Conclusion Sexual dimorphism in lung inflammation is both time and tissue compartment dependent. Spatiotemporal variability in sex differences in a murine model of asthma must be accounted for when planning experiments to model the sex bias in allergic inflammation.
Hydraulic Property and Soil Textural Classification Measurements for Rainier Mesa, Nevada Test Site, Nevada

This report presents particle size analysis, field-saturated hydraulic conductivity measurements, and qualitative descriptions of surficial materials at selected locations at Rainier Mesa, Nevada. Measurements and sample collection were conducted in the Rainier Mesa area, including unconsolidated sediments on top of the mesa, an ephemeral wash channel near the mesa edge, and dry U12n tunnel pond sediments below the mesa. Particle size analysis used a combination of sieving and optical diffraction techniques. Field-saturated hydraulic conductivity measurements employed a single-ring infiltrometer with analytical formulas that correct for falling head and spreading outside the ring domain. These measurements may prove useful to current and future efforts at Rainier Mesa aimed at understanding infiltration and its effect on water fluxes and radionuclide transport in the unsaturated zone.
Clinical evidence for a detrimental effect on uterine receptivity of high serum oestradiol concentrations in high and normal responder patients.

This study was undertaken to investigate an empirical observation that 'high responder patients have poorer in-vitro fertilization (IVF) outcome than normal responder patients'. The aim of our study was to analyse the effect of high serum oestradiol and progesterone concentrations at the day of human chorionic gonadotrophin (HCG) administration on endometrial receptivity and oocyte-embryo quality in high and normal responder patients. The IVF patients were divided into two groups: 59 high responder patients who voluntarily donated some of their oocytes, and a control group consisting of 105 normal responder patients. Both groups were compared in terms of the number and quality of oocytes retrieved, embryos transferred, fertilization, implantation and gestation rates, serum oestradiol and progesterone concentrations and the oestradiol:progesterone ratio on the day of HCG injection. To ascertain oocyte-embryo quality, a second control group of 96 women undergoing oocyte donation (receiving oocytes from high responder patients) was considered. To assess the impact of steroid concentrations on endometrial receptivity, high responder patients were divided into two subgroups according to oestradiol concentration, above or below the minimal oestradiol and progesterone concentrations (mean--SD) in this group. The normal responder patients were divided into two subgroups according to oestradiol concentration, above or below the maximal oestradiol and progesterone concentrations (mean+SD) in this group. To assess further the relevance of oestradiol concentration on endometrial receptivity, patients were divided into different subgroups according to increasing oestradiol concentration, regardless of whether they were high or normal responders. High responder patients had significantly decreased implantation and pregnancy rates per cycle compared with normal responder patients (33.3 versus 16.3 and 11.1 versus 5.4% respectively; P < 0.05). The results of 108 embryo transfers in 91 recipients who received oocytes from the high responder group showed normal embryo quality. Implantation rates and pregnancies per cycle were significantly lower in high responder patients with serum oestradiol concentrations > 1700 pg/ml compared with those having oestradiol concentrations < or = 1700 pg/ml, as well as in normal responder patients with serum oestradiol concentrations > 2200 pg/ml compared with those having oestradiol concentrations < or = 2200 pg/ml. Considering all the patients together, significant decreases in pregnancy and implantation rates were observed when oestradiol concentrations were > 2500 pg/ml compared with patients having lower oestradiol concentrations. Our clinical results demonstrate that high serum oestradiol concentrations on the day of HCG injection in high and normal responder patients, regardless of the number of oocytes retrieved and the serum progesterone concentration, are detrimental to uterine receptivity without affecting embryo quality.
Neutral wind–driven gradient drift instability in the low‐latitude daytime E region

[1] We present strong evidence for the wind-driving, daytime E region field-aligned irregularities (FAIs) on the basis of Sanya VHF radar observations on 29 June 2009. The observed sporadic E (Es) and echoing layers show a clear diurnal tidal descending trend and a gravity-wave-scale oscillation with a period of 40–50 min, which are consistent with the diurnal tidal height evolution seen from the meteor wind observations. The most important finding is that the daytime continuous FAIs are closely related to the negative vertical zonal wind shear, which also forms the dense ion layer. Associated observations suggest that the FAIs are generated on both sides of the Es layer. The echoes form two layers with 10 km vertical distance, about half the vertical wavelength of the diurnal tide. Our results, for the first time, demonstrate that the daytime E region continuous FAIs can be formed by the wind-driven gradient drift instabilities. We suggest that the latitudinal variation of the daytime E region FAI morphologies is caused by the dip angle dependence of the instability growth rate. Continuous echoes observed elsewhere at low latitudes and midlatitudes may also be attributed to the wind effects.
A live-cell platform to isolate phenotypically defined subpopulations for spatial multi-omic profiling

Numerous techniques have been employed to deconstruct the heterogeneity observed in normal and diseased cellular populations, including single cell RNA sequencing, in situ hybridization, and flow cytometry. While these approaches have revolutionized our understanding of heterogeneity, in isolation they cannot correlate phenotypic information within a physiologically relevant live-cell state with molecular profiles. This inability to integrate a live-cell phenotype—such as invasiveness, cell:cell interactions, and changes in spatial positioning—with multi-omic data creates a gap in understanding cellular heterogeneity. We sought to address this gap by employing lab technologies to design a detailed protocol, termed Spatiotemporal Genomic and Cellular Analysis (SaGA), for the precise imaging-based selection, isolation, and expansion of phenotypically distinct live cells. This protocol requires cells expressing a photoconvertible fluorescent protein and employs live cell confocal microscopy to photoconvert a user-defined single cell or set of cells displaying a phenotype of interest. The total population is then extracted from its microenvironment, and the optically highlighted cells are isolated using fluorescence activated cell sorting. SaGA-isolated cells can then be subjected to multi-omics analysis or cellular propagation for in vitro or in vivo studies. This protocol can be applied to a variety of conditions, creating protocol flexibility for user-specific research interests. The SaGA technique can be accomplished in one workday by non-specialists and results in a phenotypically defined cellular subpopulations for integration with multi-omics techniques. We envision this approach providing multi-dimensional datasets exploring the relationship between live cell phenotypes and multi-omic heterogeneity within normal and diseased cellular populations.
Remote Photoplethysmography (rPPG): A State-of-the-Art Review

Peripheral oxygen saturation (SpO2) and heart rate (HR) are critical physiological measures that clinicians need to observe to decide on an emergency intervention. These measures are typically determined using a contact-based pulse oximeter. This approach may pose difficulties in many cases, such as with young children, patients with burnt or sensitive skin, cognitive impairments, and those undergoing certain medical procedures or severe illnesses. Remote Photoplethysmography (rPPG) allows for unobtrusive sensing of these vital signs in a variety of settings for health monitoring systems. Several research studies have been conducted to use rPPG for this purpose; however, there is still not a commercially available, clinically validated system that overcomes the concerns highlighted in this paper. We present a state-of-the-art review of rPPG-related research conducted including related processes and techniques, such as regions of interest (ROI) selection, extracting the raw signal, pre-processing data, applying noise reduction algorithms, Fast Fourier transforms (FFT), filtering and extracting these vital signs. Further, we present a detailed, critical evaluation of available rPPG systems. Limitations and future directions have also been identified to aid rPPG researchers in further advancing this field.
Reliability, validity, and change thresholds of the NCCN/FACT Bladder Symptom Index (NFBlSI‐18) in patients with advanced urothelial cancer

The NCCN/FACT Bladder Symptom Index‐18 (NFBlSI‐18) is a bladder cancer–specific instrument. We aimed to psychometrically evaluate the reliability and validity of NFBlSI‐18 and estimate change thresholds for total, disease‐related symptoms‐physical (DRS‐P), DRS‐emotional (DRS‐E), and function/well‐being (F/WB) scales in patients with locally advanced/metastatic urothelial cancer (la/mUC).
Amphibian Hymenochirus boettgeri as an experimental model for infection studies with the chytrid fungus Batrachochytrium dendrobatidis

ABSTRACT Model organisms are crucial in research as they can provide key insights applicable to other species. This study proposes the use of the amphibian species Hymenochirus boettgeri, widely available through the aquarium trade, as a model organism for the study of chytridiomycosis, a disease caused by the fungus Batrachochytrium dendrobatidis (Bd) and linked to amphibian decline and extinction globally. Currently, no model organisms are used in the study of chytridiomycosis, particularly because of the lack of availability and nonstandardized methods. Thus, laboratories around the world use wild local species to conduct Bd infection experiments, which prevents comparisons between studies and reduces reproducibility. Here, we performed a series of Bd infection assays that showed that H. boettgeri has a dose- and genotype-dependent response, can generalize previous findings on virulence estimates in other species, and can generate reproducible results in replicated experimental conditions. We also provided valuable information regarding H. boettgeri husbandry, including care, housing, reproduction, and heat treatment to eliminate previous Bd infections. Together, our results indicate that H. boettgeri is a powerful and low-ecological-impact system for studying Bd pathogenicity and virulence.
Ultrasound versus computed tomography-guided transthoracic biopsy for pleural and peripheral lung lesions: a systematic review and meta-analysis

Background An accurate diagnosis of peripheral lung and pleural lesions using image-guided transthoracic biopsy procedure becomes a good diagnostic performance protocol. Purpose To examine the difference between ultrasonography (USG)-guided versus computed tomography (CT)-guided transthoracic biopsy for pleural and peripheral lung lesions by pooling data from published studies. Material and Methods PubMed, CENTRAL, Scopus, Web of Science, and Embase were searched for comparative studies up to 20 February 2023 irrespective of the language of publication. The outcomes were adequacy of the sample and complications (pneumothorax and hemothorax). Results Two randomized controlled trials (RCTs) and eight non-RCTs were eligible. The total sample size was 1618. Meta-analysis showed that there was no difference in the adequacy of the sample obtained by USG- or CT-guided biopsies; however, an analysis of only non-RCTs indicated better adequacy with USG. On pooled analysis of any pneumothorax, there was a lower risk associated with USG-guided biopsies, but the risk of pneumothorax requiring interventional treatment was not different in the two groups. Similarly, the pooled analysis also demonstrated a reduced risk of hemothorax with USG-guided biopsies. Conclusion While there seems to be no difference in the adequacy of the sample obtained with either imaging modality, retrospective data show that USG guidance offers better diagnostic yield compared to CT guidance for peripheral lung and pleural biopsies. The risk of pneumothorax and hemothorax is also significantly lower with USG-guided biopsies. Results should be interpreted with caution owing to selection bias among studies. There is a need for large-scale RCTs to enhance current evidence.
Association between fractional exhaled nitric oxide and therapeutic adherence to controller management in pediatric asthma patients

Guidelines for asthma management recommend, before establishing additional therapeutic behaviors, to confirm correct use and adequate therapeutic adherence to treatment. Evidence exists on the use of fractional exhaled nitric oxide (FeNO) values for monitoring therapeutic adherence in adults. It is important to establish whether there is a correlation between FeNO and therapeutic adherence in children. This study aims to provide new knowledge about the relationship between FeNO and therapeutic adherence in asthmatic children.
The hydrogeology of the Tully Valley, Onondaga County, New York: an overview of research, 1992-2012

Onondaga Creek begins approximately 15 miles south of Syracuse, New York, and flows north through the Onondaga Indian Nation, then through Syracuse, and finally into Onondaga Lake in central New York. Tully Valley is in the upper part of the Onondaga Creek watershed between U.S. Route 20 and the Valley Heads end moraine near Tully, N.Y. (fig. 1). Tully Valley has a history of several unusual hydrogeologic phenomena that affected past land use and the water quality of Onondaga Creek; the phenomena are still present and continue to affect the area today (2014). These phenomena include mud volcanoes or mudboils, landslides, and land-surface subsidence; all are considered to be naturally occurring but may also have been influenced by human activity. The U.S. Geological Survey (USGS), in cooperation with the U.S. Environmental Protection Agency and the Onondaga Lake Partnership, began a study of the Tully Valley mudboils beginning in October 1991 in hopes of understanding (1) what drives mudboil activity in order to remediate mudboil influence on the water quality of Onondaga Creek, and (2) land-surface subsidence issues that have caused a road bridge to collapse, a major pipeline to be rerouted, and threatened nearby homes. Two years into this study, the 1993 Tully Valley landslide occurred just over 1 mile northwest of the mudboils. This earth slump-mud flow was the largest landslide in New York in more than 70 years (Fickies, 1993); this event provided additional insight into the geology and hydrology of the valley. As the study of the Tully Valley mudboils progressed, other unusual hydrogeologic phenomena were found within the Tully Valley and provided the opportunity to perform short-term, smallscale studies, some of which became graduate student theses— Burgmeier (1998), Curran (1999), Morales-Muniz (2000), Baldauf (2003), Epp (2005), Hackett, (2007), Tamulonis (2010), and Sinclair (2013). The unusual geology and hydrology of the Tully Valley, having been investigated for more than two decades, provides the basis for this report. Purpose of Report
Seismological evidence of stress induced by dike injection during the 2001 Mt. Etna eruption

A selected dataset of 151 events, leading the July 17–August 9, 2001 lateral eruption at Mt. Etna volcano, has been analyzed for three‐dimensional hypocenter locations, focal mechanisms and stress tensor inversions. The seismic pattern provided indications for two main spatial clusters of foci located along and eastwards of the 2001 Mt. Etna eruptive fractures system. The 151 fault plane solutions (mostly strike slip) were inverted for stress tensor parameters, and space variations of seismogenic stress orientations have been identified. The stress inversion results and the axi‐symmetric orientation of P‐axes, in the region surrounding the modeled dike, well support the evidence of a unique stress source in agreement with the ground deformation results.
Atomistic structure of the SARS-CoV-2 pseudoknot in solution from SAXS-driven molecular dynamics

Abstract SARS-CoV-2 depends on −1 programmed ribosomal frameshifting (−1 PRF) to express proteins essential for its replication. The RNA pseudoknot stimulating −1 PRF is thus an attractive drug target. However, the structural models of this pseudoknot obtained from cryo-EM and crystallography differ in some important features, leaving the pseudoknot structure unclear. We measured the solution structure of the pseudoknot using small-angle X-ray scattering (SAXS). The measured profile did not agree with profiles computed from the previously solved structures. Beginning with each of these solved structures, we used the SAXS data to direct all atom molecular dynamics (MD) simulations to improve the agreement in profiles. In all cases, this refinement resulted in a bent conformation that more closely resembled the cryo-EM structures than the crystal structure. Applying the same approach to a point mutant abolishing −1 PRF revealed a notably more bent structure with reoriented helices. This work clarifies the dynamic structures of the SARS-CoV-2 pseudoknot in solution.
Synthesis of Ultra-Incompressible and Recoverable Carbon Nitrides Featuring CN4 Tetrahedra.

Carbon nitrides featuring 3D frameworks of CN4 tetrahedra were identified as one of the great aspirations of materials science, expected to have a hardness greater than or comparable to diamond. After more than three decades of efforts to synthesize them, no unambiguous evidence of their existence has been delivered. Here, we report the high-pressure high-temperature synthesis of three carbon-nitrogen compounds, tI14-C3 N4 , hP126-C3 N4 , and tI24-CN2 , in laser-heated diamond anvil cells. Their structures were solved and refined using synchrotron single-crystal X-ray diffraction. Physical properties investigations showed that these strongly covalently bonded materials, ultra-incompressible and superhard, also possess high energy density, piezoelectric, and photoluminescence properties. The novel carbon nitrides are unique among high-pressure materials, as being produced above 100 GPa they are recoverable in air at ambient conditions. This article is protected by copyright. All rights reserved.