Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevention of Carotid Artery Thrombosis After Oral Administration of the Glycoprotein IIb/IIIa Antagonist CRL42796

&NA; This study investigates the effect of the glycoprotein IIb/IIIa receptor antagonist CRL42796 in a canine model of carotid artery thrombosis. Both carotid arteries developed occlusive thrombosis in each of the five control animals (time to occlusion: right carotid artery, 92.6 minutes; left carotid artery, 89.0 minutes). A single oral dose of CRL42796 (3 mg/kg) prevented occlusive thrombosis in 4 of 6 vessels and increased time to thrombosis, albeit not significantly (right carotid artery, 134.1 minutes; left carotid artery, 145.0 minutes). When the initial dose of CRL42796 was followed by a second oral dose (3 mg/kg) 2 hours later, 10 of 10 carotid arteries remained patent throughout the period of electrolytic injury. CRL42796 reduced thrombus weight in both treatment protocols. Ex vivo platelet aggregation with arachidonic acid (AA) or adenosine diphosphate (ADP) was reduced at 120, 240, and 360 minutes after two doses of CRL42796. A single oral dose reduced ADP‐induced responses at 240 and 360 minutes, but significant effects were not observed with AA. Bleeding time increased 360 minutes after two oral doses of CRL42796, but not at 120 minutes. Bleeding time was unchanged with the single dose of CRL42796. The results demonstrate that oral administration of CRL42796 prevents carotid artery thrombosis in response to deep vessel wall injury and may have potential value to be characterized in extended preclinical and clinical study.
Rod Phototransduction Determines the Trade-Off of Temporal Integration and Speed of Vision in Dark-Adapted Toads

Human vision is ∼10 times less sensitive than toad vision on a cool night. Here, we investigate (1) how far differences in the capacity for temporal integration underlie such differences in sensitivity and (2) whether the response kinetics of the rod photoreceptors can explain temporal integration at the behavioral level. The toad was studied as a model that allows experimentation at different body temperatures. Sensitivity, integration time, and temporal accuracy of vision were measured psychophysically by recording snapping at worm dummies moving at different velocities. Rod photoresponses were studied by ERG recording across the isolated retina. In both types of experiments, the general timescale of vision was varied by using two temperatures, 15 and 25°C. Behavioral integration times were 4.3 s at 15°C and 0.9 s at 25°C, and rod integration times were 4.2–4.3 s at 15°C and 1.0–1.3 s at 25°C. Maximal behavioral sensitivity was fivefold lower at 25°C than at 15°C, which can be accounted for by inability of the “warm” toads to integrate light over longer times than the rods. However, the long integration time at 15°C, allowing high sensitivity, degraded the accuracy of snapping toward quickly moving worms. We conclude that temporal integration explains a considerable part of all variation in absolute visual sensitivity. The strong correlation between rods and behavior suggests that the integration time of dark-adapted vision is set by rod phototransduction at the input to the visual system. This implies that there is an inexorable trade-off between temporal integration and resolution.
Corporate Citizenship and Managerial Motivation: Implications for Business Legitimacy

In 2000, Business and Society Review published a Special Issue of the journal to explore scholars’ ideas about how the practice of corporate citizenship would evolve in the 21st century. Contributors to the volume predicted a change in business motives for engaging in social initiatives, suggesting that managers would begin to see corporate citizenship as a strategic necessity to preserve organizational legitimacy in the face of changing social values. This article uses data from a study of corporate citizenship practices in over 500 Norwegian companies to explore the validity of the Special Issue predictions. We begin by reviewing the foundations of organizational legitimacy theory and examine recent research documenting the growing importance of corporate citizenship for assessments of business legitimacy. We describe our study methods, present our results, and discuss the implications of our findings in this context.
An intergroup approach to second language acquisition

Abstract In this paper, we shall outline a recent social psychological approach to language and ethnicity which attends to the issue: who in an ethnic group uses what language variety, when and why? More specifically, it allows us to understand the processes underlying group members’ desires to attenuate and even create their own distinctive ethnolinguistic varieties (Giles, Bourhis & Taylor, 1977; Giles & Johnson, 1981). It is suggested that this framework is likely to advance our knowledge of factors influencing successful acquisition of a second language. Two current social psychological models of second language acquisition in inter‐ethnic contexts (Gardner, 1979; Clement, 1980a; 1980b) are then compared and evaluated critically. Whilst these models exhibit significant theoretical advances in the area, it is argued that they nonetheless possess certain deficiencies. Prime amongst these concerns is their failure to take into account explicitly processes (such as ethnic identification) which are accorde.
The assumption of anarchy in international relations theory: a critique

‘Anarchy is one of the most vague and ambiguous words in language. ’ George Coreewall Lewis, 1832. In much current theorizing, anarchy has once again been declared to be the fundamental assumption about international politics. Over the last decade, numerous scholars, especially those in the neo-realist tradition, have posited anarchy as the single most important characteristic underlying international relations. This article explores implications of such an assumption. In doing so, it reopens older debates about the nature of international politics. First, I examine various concepts of ‘anarchy’ employed in the international relations literature. Second, I probe the sharp dichotomy between domestic and international politics that is associated with this assumption. As others have, I question the validity and utility of such a dichotomy. Finally, this article suggests that a more fruitful way to understand the international system is one that combines anarchy and interdependence.
Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism

Autism is a behaviorally defined neurodevelopmental disorder usually diagnosed in early childhood that is characterized by impairment in reciprocal communication and speech, repetitive behaviors, and social withdrawal. Although both genetic and environmental factors are thought to be involved, none have been reproducibly identified. The metabolic phenotype of an individual reflects the influence of endogenous and exogenous factors on genotype. As such, it provides a window through which the interactive impact of genes and environment may be viewed and relevant susceptibility factors identified. Although abnormal methionine metabolism has been associated with other neurologic disorders, these pathways and related polymorphisms have not been evaluated in autistic children. Plasma levels of metabolites in methionine transmethylation and transsulfuration pathways were measured in 80 autistic and 73 control children. In addition, common polymorphic variants known to modulate these metabolic pathways were evaluated in 360 autistic children and 205 controls. The metabolic results indicated that plasma methionine and the ratio of S‐adenosylmethionine (SAM) to S‐adenosylhomocysteine (SAH), an indicator of methylation capacity, were significantly decreased in the autistic children relative to age‐matched controls. In addition, plasma levels of cysteine, glutathione, and the ratio of reduced to oxidized glutathione, an indication of antioxidant capacity and redox homeostasis, were significantly decreased. Differences in allele frequency and/or significant gene–gene interactions were found for relevant genes encoding the reduced folate carrier (RFC 80G > A), transcobalamin II (TCN2 776G > C), catechol‐O‐methyltransferase (COMT 472G > A), methylenetetrahydrofolate reductase (MTHFR 677C > T and 1298A > C), and glutathione‐S‐transferase (GST M1). We propose that an increased vulnerability to oxidative stress (endogenous or environmental) may contribute to the development and clinical manifestations of autism. © 2006 Wiley‐Liss, Inc.
Patent collaborative filtering recommendation approach based on patent similarity

In order to help enterprises deal with the situation of sharp increase in patent amount and improve enterprises' capabilities for patent utilization, the information filtering technology was introduced into patent management field. A patent collaborative filtering recommendation approach based on patents similarity and its corresponding algorithm was presented. This approach solves the problem of user rating data sparsity successfully: firstly, it calculates similarity between patents based on the concept of patent model tree, then predicts patent score with patents similarity, fills user rating matrix, and finally it calculates users' similarity to finish patent recommendation. Preliminary experimental results showed that the patent collaborative filtering recommendation approach based on patent similarity has a good performance in recommending patents and patent management system employing this approach can improve enterprises' capabilities in patent utilization.
Coordinated Concentration Changes of Transcripts and Metabolites in Saccharomyces cerevisiae

Metabolite concentrations can regulate gene expression, which can in turn regulate metabolic activity. The extent to which functionally related transcripts and metabolites show similar patterns of concentration changes, however, remains unestablished. We measure and analyze the metabolomic and transcriptional responses of Saccharomyces cerevisiae to carbon and nitrogen starvation. Our analysis demonstrates that transcripts and metabolites show coordinated response dynamics. Furthermore, metabolites and gene products whose concentration profiles are alike tend to participate in related biological processes. To identify specific, functionally related genes and metabolites, we develop an approach based on Bayesian integration of the joint metabolomic and transcriptomic data. This algorithm finds interactions by evaluating transcript–metabolite correlations in light of the experimental context in which they occur and the class of metabolite involved. It effectively predicts known enzymatic and regulatory relationships, including a gene–metabolite interaction central to the glycolytic–gluconeogenetic switch. This work provides quantitative evidence that functionally related metabolites and transcripts show coherent patterns of behavior on the genome scale and lays the groundwork for building gene–metabolite interaction networks directly from systems-level data.
SCIENTIFIC COMMUNICATION, INNOVATION NETWORKS AND ORGANIZATION STRUCTURES*

This article examines changes in the relation between the organization of social power, the production of advanced scientific knowledge, and the position of scientific and technical personnel, from an institutionalist perspective. This is undertaken largely, but not exclusively, by mapping an exemplar of such inter-institutional and intra-disciplinary changes, i.e. the transformation in high-energy physics associated with the development of the atomic bomb. the contrast between the social imperatives of dominant sponsoring institutions and the organizational preconditions for cognitive efficacy is seen as regulated through the emergence of innovation networks. the article concludes with a brief consideration of the relation between the strategies of knowledge workers and the structure of such networks.
Modeling signals of small tumors inside the breast in ultra-wide frequency band

Investigation of signals scattered off small tumors inside breast was provided analytically in Rayleigh and Mie approaches. In additional, we estimated the spatial resolution of microwave images in the diffraction limit approach. All results were obtained for four main breast classes in ultra wide frequency band - from 0.5 to 10 GHz. Such an investigation is important for analysis and design of advanced tomography systems for the early breast cancer detection.
Cognitive styles: enhancing the developmental component in National Vocational Qualifications

Outlines the findings of a study designed to inform current practice in developing UK National Vocational Qualifications (NVQ) and Scottish Vocational Qualifications (SVQ). Explores the link between an individual’s cognitive style and their successful management and completion of such a structured award. Adopts the Kirton Adaptation‐Innovation (KAI) instrument, as this represents an inventory designed to explore problem‐solving and information management styles. Provides insights to illuminate particular coping strategies and methods using candidates’ profiles and reports from interviews. The KAI results indicate that both adapters and innovators showing a low efficiency score managed more effectively with the storyboard and whole NVQ process. Points to the likely benefits for both candidates and organisations of appropriate supportive mechanisms to enhance the developmental aspects of gaining an NVQ.
The Consequences of International Comparisons for Public Support of K–12 Education

Candidates for public office in the United States frequently justify their positions on education policy priorities by stating the need to strengthen the nation’s economic competitiveness against new global challengers. In this article, the authors investigate the consequences of this form of policy motivation for attitudes toward and support of public schooling in the United States. Using a national survey experiment where a two-question prime on international competitiveness is randomized across respondents, the authors test for differential responses to attitude items that have been included regularly since the 1970s in the Phi Delta Kappa/Gallup Poll and the General Social Survey. The results suggest that framing educational policy with the goal of enhancing international competitiveness lowers subjective assessments of the quality of local schooling without increasing interest in additional spending to improve the nation’s education system.
Ten steps to cognitive behavioural supervision

Abstract Clinical supervision is recognized as essential for CBT therapists, both during training and in subsequent practice, and there has been a rapidly growing demand for accredited therapists to become supervisors. However, this can be a daunting prospect. Supervision is a highly complex activity with several overlapping purposes, in which the supervisor must enact multiple roles and use varied modes of activity. Research on the process has been limited, but a consensus on good practice and evidence-based procedures is beginning to emerge. Against this backdrop, a sequence of steps to be taken within any CBT supervision session is presented here. The structure is applicable across all levels of expertise. The purpose is to give clear and accessible guidance to supervisors to ensure they adhere to best practice and manage sessions in an efficient, helpful and well-focused style.
Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans

Background Existing rodent models of vascular cognitive impairment (VCI) show abrupt changes in cerebral blood flow (CBF) and do not reliably replicate the clinical pathogenesis of VCI. We therefore aimed to develop a mouse model of VCI where CBF is gradually reduced, followed by subsequent progressive motor and cognitive impairment, after surgical intervention. Methods and Results Adult C57BL/6J male mice were subjected to gradual common carotid artery stenosis (GCAS) surgery by using an ameroid constrictor vessel‐constricting device with an inner diameter of 0.75 mm. The common carotid arteries narrowed gradually after gradual constriction of ameroid constrictors over 28 days after GCAS, with subsequent 79.3% area stenosis as a result of smooth muscle cell proliferation and macrophage infiltration in the tunica intima. The 28‐day survival rate was 91%. Arterial spin labeling demonstrated gradual and continuous reduction of cortical and subcortical CBF (ratio to the preoperative value) to 54.6% and 51.5%, respectively, over 28 days. However, magnetic resonance angiography showed increment of collateral flow signals in the leptomeningeal artery. Rarefaction and proliferation of astrocytes and microglia, with loss of oligodendrocytes, were found in the white matter at 32 days. Hippocampal neuronal loss was observed in only 25% of GCAS mice, consistent with lack of abnormalities in the Morris water maze test. The rotarod test showed motor impairment, and the Y‐maze test showed working memory deficits. Conclusions The GCAS model successfully generated gradual and continuous CBF reduction over 28 days, with replication of key histological, radiological, and behavioral features associated with cerebral hypoperfusion leading to VCI.
A real-time robust facial expression recognition system using HOG features

This paper presents a facial expression recognition framework which infers the emotional states in real-time, thereby enabling the computers to interact more intelligently with people. The proposed method determines the face as well as the facial landmark points, extracts discriminating features from suitable facial regions, and classifies the expressions in real-time from live webcam feed. The speed of the system is improved by the appropriate combination of the detection and tracking algorithms. Further, instead of the whole face, histogram of oriented gradients (HOG) features are extracted from the active facial patches which makes the system robust against the scale and pose variations. The feature vectors are further fed to a support vector machine (SVM) classifier to classify into neutral or six universal expressions. Experimental results show an accuracy of 95% with 5 folds cross-validation in extended Cohn-Kanade (CK+) dataset.
THE EFFECT OF VIEWING SLANT AND DISTANCE ON SOME VISUAL ILLUSIONS

Abstract This study is concerned with the effect of (a) viewing slant and (b) viewing distance on the perception of 9 illusions which involve straight parallel lines or squares embedded in geometrical patterns. 32 Ss, all of them University students, took part in the experiment. The results show (a) that at a reduced viewing slant the illusory effect disappears with all 9 stimulus figures, the required viewing slant being greater for squares than for parallel lines, (b) that the illusory effects disappear as a function of distance of observation with all 9 stimulus figures, the distance varying from one figure to another. The disappearance of such effects is considered to be a function of fixations on the illusory patterns.
Single particle tracking of surface receptor movement during cell division

We have used fluorescent latex beads to label membrane receptors on cultured NRK cells. Movement of individual beads during cell division was recorded with digital imaging techniques. Surface-bound beads showed no organized movement during metaphase but started to migrate toward the equator approximately 1 min after anaphase onset, when chromosomes moved out of the equatorial region to create the interzone. The movement was most active in the central region of the cell near separating chromosomes, while beads located near the poles of the cell underwent primarily random motion. Most beads showed a surge in speed upon the passage of chromosomes, suggesting a possible link between chromosome separation and cortical reorganization. Furthermore, treatment of anaphase cells with cytochalasin D induced a rapid, simultaneous collapse of beads and cortical actin filaments into aggregates, indicating that the movement of beads was closely related to the reorganization of the actin cortex. In contrast to normal directional movement, cytochalasin-induced movement occurred in random directions and caused some beads in the equatorial region to move toward poles. Our results indicate that cytokinesis involves contractile activities, not only along the equator, but over a wide area of the actin-containing cortex. In addition, organized cortical activities appear to be temporally activated at anaphase onset, and spatially modulated by the spindle interzone or separating chromosomes.
Analyzing Semantic Segmentation Using Hybrid Human-Machine CRFs

Recent trends in semantic image segmentation have pushed for holistic scene understanding models that jointly reason about various tasks such as object detection, scene recognition, shape analysis, contextual reasoning. In this work, we are interested in understanding the roles of these different tasks in aiding semantic segmentation. Towards this goal, we "plug-in" human subjects for each of the various components in a state-of-the-art conditional random field model (CRF) on the MSRC dataset. Comparisons among various hybrid human-machine CRFs give us indications of how much "head room" there is to improve segmentation by focusing research efforts on each of the tasks. One of the interesting findings from our slew of studies was that human classification of isolated super-pixels, while being worse than current machine classifiers, provides a significant boost in performance when plugged into the CRF! Fascinated by this finding, we conducted in depth analysis of the human generated potentials. This inspired a new machine potential which significantly improves state-of-the-art performance on the MRSC dataset.
Biodegradable Polymeric Capsules Obtained via Room Temperature Spray Drying: Preparation and Characterization

The aim of this contribution is to determine the relationship existent between the chemistry and/or viscosity of some biodegradable polymer solutions and the morphology of micro- and nanospheres resulted after spray drying the solutions at room conditions either in the presence or in the absence of an encapsulated aqueous material. Using dichloromethane as solvent, the following polyesters were used to prepare 2 wt% solutions: polyhydroxybutyrate (PHB), polylactic acid (PLA), poly(lactic-co-glycolic acid) (PLGA) and Eastar Bio GP (GP). A comprehensive thermal characterization was also performed on all polymers to verify the relationships existent between the structure of polyesters and certain important parameters, such as Tg, T m, Td . It was observed that a decrease in the solution viscosity triggers the formation of smoother microspheres. When the viscosity becomes low enough the sprayed solution can lead to the development of well defined nanospheres instead of microspheres. Additionally, it was found that in the presence of an aqueous core the micro- and/or nanocapsules coalesce into larger micrometric aggregates, due to the plasticizing effects of water on the polyester.
Entrepreneuriat familial et stratégies de pérennité : contribution au concept d’innovation prudentielle

L’objectif de cette recherche est d’analyser les comportements en matiere d’innovation d’entreprises familiales perennes. Une analyse de donnees secondaires constituees detemoignages relatifs a l’innovation dans des firmes familiales perennes met en evidence la recherche constante d’arbitrage entre stabilite et renouvellement, et le poids des traditionsagissant comme garde-fou des strategies d’innovation. Puis, des choix strategiques d’innovation realises par une entreprise familiale perenne sont analyses en profondeur et permettentde specifier le concept d’innovation prudentielle. Cette notion est ensuite precisee a l’aide de sept caracteristiques puisant toutes leur origine dans les traits communement acceptesdes firmes familiales perennes.