Miracle-dz/UniFAR-FTUs huggingface dataset:
Impacting Children's Physical and Mental Health Through Kinesiology Support in Clinical Care: A Randomized Controlled Trial Protocol

Objectives: To enhance the confidence of children and adolescents with medical conditions and disabilities to engage in healthy, active lifestyles. Children with medical conditions and disabilities often exhibit more sedentary lifestyles relative to peers and are at increased risk of poor health outcomes. Clinical experience suggests physical activity confidence is an important factor influencing physical activity participation.Methods: This randomized controlled trial evaluates an evidence-based intervention targeting physical activity confidence among children and adolescents with medical conditions and disabilities. Potential participants, 8 to 18 years of age diagnosed with a medical condition or disability, will be screened for adequate physical activity motivation but a lack confidence. Consenting participants (n=128) will be randomized 1:1 to a 12-week in-person or virtual physical activity intervention (24 hours/week total) led by a Registered Kinesiologist or control (assessments only). The intervention will combine physical activity participation with education about physical activity knowledge, goal setting, motivation and self-management. Primary outcomes are self-reported physical activity confidence and motivation at baseline, post-intervention and three months following intervention completion. A secondary outcome will be daily physical activity minutes assessed by accelerometry. A repeated measures mixed model will be used to compare outcomes between the in-person intervention, virtual intervention, and control groups (alpha=0.05). Conclusions: This trial aims to assess the impact of a novel application of behaviour change theory on physical activity confidence among children and adolescents living with medical conditions or disabilities. Increased physical activity confidence, knowledge and skills could enable these youth to lead a more active lifestyle.
How people perceive malicious comments differently: factors influencing the perception of maliciousness in online news comments

This study proposes a comprehensive model to investigate the factors that influence the perceived maliciousness of online news comments. The study specifically examines individual factors, including demographic characteristics (e.g., gender and age), personality traits (e.g., empathy and attitudes toward online news comments), and reading-related factors (e.g., the amount of news comment reading). Contextual factors such as issue involvement, perceived peer behavior, and the presence of malicious comments in news articles are also considered. The results suggest that most of the proposed variables have a significant impact on the perceived maliciousness of online news comments, except for morality and issue involvement. The findings have important theoretical implications for research on malicious online news comments and provide practical guidelines for online news platforms on how to reduce malicious comments by visualizing them alongside other news comments.
A Novel Two-Stage Induced Deep Learning System for Classifying Similar Drugs with Diverse Packaging

Dispensing errors play a crucial role in various medical errors, unfortunately emerging as the third leading cause of death in the United States. This alarming statistic has spurred the World Health Organization (WHO) into action, leading to the initiation of the Medication Without Harm Campaign. The primary objective of this campaign is to prevent dispensing errors from occurring and ensure patient safety. Due to the rapid development of deep learning technology, there has been a significant increase in the development of automatic dispensing systems based on deep learning classification to avoid dispensing errors. However, most previous studies have focused on developing deep learning classification systems for unpackaged pills or drugs with the same type of packaging. However, in the actual dispensing process, thousands of similar drugs with diverse packaging within a healthcare facility greatly increase the risk of dispensing errors. In this study, we proposed a novel two-stage induced deep learning (TSIDL)-based system to classify similar drugs with diverse packaging efficiently. The results demonstrate that the proposed TSIDL method outperforms state-of-the-art CNN models in all classification metrics. It achieved a state-of-the-art classification accuracy of 99.39%. Moreover, this study also demonstrated that the TSIDL method achieved an inference time of only 3.12 ms per image. These results highlight the potential of real-time classification for similar drugs with diverse packaging and their applications in future dispensing systems, which can prevent dispensing errors from occurring and ensure patient safety efficiently.
Digital economy and carbon emission reduction: evidence from China

ABSTRACT China confronts a challenging dilemma between environmental protection and economic development as it endeavors to achieve dual carbon goals. To discern a feasible developmental path, this paper designs a comprehensive index of the digital economy encompassing four dimensions: input, production, output, and consumption, conducts an empirical analysis to explore the relationship between the digital economy and carbon emissions by using a two-way fixed effect model with China’s provincial data from 2013 to 2019, and suggests that the digital economy can significantly reduce carbon emissions and carbon intensity. Public low carbon awareness and green innovation are mechanisms that mediate the association between the digital economy and carbon emissions. The carbon reduction effect varies across dimensions of the digital economy, regions, and sources of carbon emissions. These empirical findings provide valuable insights and policy implications to effectively achieve China’s dual carbon goals.
Adaptive fault‐tolerant time‐varying formation tracking for multiagent systems with multiple leaders

In this paper, an adaptive fault‐tolerant time‐varying formation control problem for nonlinear multiagent systems with multiple leaders is studied against actuator faults and state‐dependent uncertainties. Simultaneously, the followers form a predefined formation while tracking reference signal determined by the convex combination of the multiple leaders. Based on the neighboring relative information, an adaptive fault‐tolerant formation time‐varying control protocol is constructed to compensate for the influences of actuator faults and model uncertainties. In addition, the updating laws can be adjusted online through the adaptive mechanism, and the proposed control protocol can guarantee that all the signals in the closed‐loop systems are bounded. Lyapunov‐like functions are addressed to prove the stability of multiagent systems. Finally, two examples are provided to demonstrate the effectiveness of the theoretical results.
The Effectiveness of a Smartphone Application for Tinnitus Relief

Background: There has been a growing interest in the provision of smartphone- or internet-based tinnitus management. Studies have shown a positive impact of the smartphone applications on tinnitus symptoms. However, research into a relatively long-term effect of these applications on tinnitus relief as well as sound preferences has been sparse. This study explored the potential benefit of a tinnitus application in tinnitus relief over a period of six months. Methods: Twenty-two participants with subjective tinnitus were enrolled in the study. Puretone audiometry, tinnitus pitch and loudness matching, stress assessment, and questionnaires were completed at the initial visit and three and six months after the first visit. The participants used the tinnitus application for six months. Results: A significant reduction in subjective tinnitus loudness and annoyance and subjective stress level was observed. The Tinnitus Handicap Inventory scores were also significantly decreased after six months. The participants also reported high satisfaction with the application. Music and environmental sounds were the most preferred sound stimuli. Conclusions: The findings of this study demonstrate the potential benefit of the tinnitus application for tinnitus improvement.
The Effect of Market Orientation, HR Competence, Knowledge Management on Competitive Advantage, Mediated by Company Performance

Purpose: The condition of competition between coal mining contractors causes the company leaders to manage the company and try as optimally as possible to get a competitive advantage compared to other similar companies. This study discusses the relationship of Competitive Advantage built from Market Orientation variables, HR Competence, and Knowledge Management to the performance of coal mining contractors in a comprehensive manner. It explains the transformation process of Company Performance to Competitive Advantage. Research implications: A research population is a number of 37 Coal mining contractors in Indonesia, including employees who are directly involved in strategic decision making in the company, namely the Project Head, Head Office Manager, and Director as respondents. Based on these data, Smart PLS 4 software processes structural parameter estimates according to the relational model described in the study's conceptual framework. Results and conclusion: The results showed that Market Orientation, Knowledge Management and Company Performance have a significant effect on Competitive Advantage, Quality of Human Resources, Market Orientation and Knowledge Management also has a direct effect on Company Performance, but Quality of Human Resources has no significant effect on Competitive Advantage. While the Company's Performance is a Full Mediation of the Quality of Human Resources on Competitive Advantage. Originality/value: This research contributes to the development of RBV theory, especially the study of company performance on competitive advantage in a resource-based view perspective through market orientation, HR competence, knowledge management, and the practice of applying SECI knowledge to this research object, which is proven to be able to increase competitive advantage. Theoretical reference: The originality of the theoretical model in this study contributes to the development of the RBV theory, the implementation of the concept of Competitive Advantage regarding the integration of internal key resources between intangible and capability aspects of coal mining contractors.
Exercise Capacity in Very Low Birth Weight Adults: A Systematic Review and Meta-Analysis

There is an association between very low birth weight (VLBW) and cardiovascular morbidity and mortality in adulthood. Aerobic fitness, measured as the maximal oxygen consumption (VO2 max), is a good indicator of cardiopulmonary health and predictor of cardiovascular mortality. Our aim was to determine the effect of birth weight on aerobic exercise capacity and physical activity. We systematically identified studies reporting exercise capacity (VO2 max and VO2 peak) and physical activity levels in participants born at VLBW aged eighteen years or older compared to term-born controls from six databases (MEDLINE, OVID, EMBASE, CI NAHL, CENTRAL, and Google Scholar). Meta-analysis of eligible studies was conducted using a random effect model. We screened 6202 articles and identified 15 relevant studies, 10 of which were eligible for meta-analysis. VLBW participants had a lower VO2 max compared to their term counterparts (−3.35, 95% CI: −5.23 to −1.47, p = 0.0005), as did VLBW adults who had developed bronchopulmonary dysplasia (−6.08, 95% CI −11.26 to −0.90, p = 0.02). Five of nine studies reported significantly reduced self-reported physical activity levels. Our systematic review and meta-analysis demonstrated reduced maximal aerobic exercise capacity in adults born at VLBW compared to term-born controls.
PERBANDINGAN KARAKTERISTIK SERAT KARBON ANTARA METODE MANUAL LAY-UP DAN VACUUM INFUSION DENGAN PENGGUNAAN FRAKSI BERAT SERAT 60%

Penelitian ini dilakukan untuk menentukan perbedaan karakteristik material komposit serat karbon dengan dua metode laminasi antara manual lay-up dan vacuum infusion. Penelitian terbagi dalam beberapa tahapan. Tahap pertama pembuatan specimen komposit dengan fraksi berat serat 60% dengan lapisan serat sebanyak 10 layer untuk uji tarik dan 40 layer untuk uji impak. Matriks yang digunakan yaitu resin epoksi. Tahap kedua adalah pengujian bajan komposit. Pengujian yang dilakukan yaitu uji tarik dan uji impak. Uji tarik dilakukan dengan menggunakan standar ASTM D3039 dan uji impak menggunakan standar ASTM 6110. Tahap terakhir yaitu hasil Analisa data dan pembahasan. Hasil pengujian kekuatan tarik komposit dengan metode vacuum infusion memiliki kekuatan tarik dan harga impak paling baik dengan kekuatan tarik sebesar 595.63 MPa dan modulus elastisitas sebesar 6976 MPa sedangkan energi yang diserap 2433.65 J dengan harga impaknya 33.25 J/cm2. Pengujian pada specimen metode manual lay-up memiliki kekuatan tarik sebesar 581.93 MPa dan modulus elastisitas sebesar 10.241 MPa sedangkan energi yang diserap 2212.59 J dengan harga impak 29.41 J/cm2. Berdasarkan hasil tersebut dapat dikatakan metode vacuum infusion memiliki karakteristik yang lebih baik dibandingkan metode manual lay-up.
Endgame in the Balkans: Regime Change, European Style

Can Europe tame the Balkans? That's the question veteran journalist Elizabeth Pond addresses in this timely and absorbing book. Starting with the wars of the Yugoslav succession, Endgame in the Balkans guides readers through the region's tumultuous recent history and explores both how the lure of European Union (EU) membership has affected the Balkans and how Balkan developments have shaped the EU. Drawing on hundreds of interviews, as well as decades of experience as a foreign correspondent, Pond moves deftly across the region, from Bulgaria to Romania, Kosovo, Croatia, Bosnia, Macedonia, Albania, and Serbia and Montenegro. She examines the many hurdles standing between these countries and EU membership --including poverty, corruption, and rabid chauvinism --as well as the hopes and problems that have led Balkan leaders to look to the West. In the process, she paints a vivid picture of the challenges facing the region as it seeks to vault from the nineteenth to the twenty-first century. Already in its brief history, the European Union has forged a historic reconciliation between France and Germany and helped consolidate democracy in Portugal, Spain, and Greece. But in southeastern Europe, it faces one of its most difficult tasks yet. En dgame in the Balkans r eveals the full extent of this challenge, as well as the grounds for hope. Rich in detail and penetrating analysis, this book will be essential reading for anyone interested in the future both of the region and of Europe as a whole.
A Systemically Administered Unconjugated Antisense Oligonucleotide Targeting DUX4 Improves Muscular Injury and Motor Function in FSHD Model Mice

Facioscapulohumeral muscular dystrophy (FSHD), one of the most common muscular dystrophies, is caused by an abnormal expression of the DUX4 gene in skeletal muscles, resulting in muscle weakness. In this study, we investigated MT-DUX4-ASO, a novel gapmer antisense oligonucleotide (ASO). MT-DUX4-ASO decreased the expression of DUX4 and its target genes in FSHD patient-derived myoblasts. For the first time, we demonstrated that a systemically administered ASO, even without a ligand for drug delivery, could significantly improve muscle injury and motor function in the ACTA1-MCM/FLExDUX4 (DUX4-TG) mouse model of FSHD. Tamoxifen (TMX) injection transiently induces skeletal-muscle-specific DUX4 expression in DUX4-TG mice, while the skeletal muscles of TMX-untreated DUX4-TG mice have leaky DUX4 expression in a small subset of myofibers similar to those of FSHD patients. Subcutaneous 10 mg/kg of MT-DUX4-ASO at two-week intervals significantly suppressed muscular DUX4 target gene expression, histological muscle injury, and blood muscle injury marker elevation in TMX-untreated DUX4-TG mice. Notably, MT-DUX4-ASO at 10 mg/kg every other week significantly prevented the TMX-induced declines in treadmill test running speed and muscle force in DUX4-TG mice. Thus, the systemically administered unconjugated MT-DUX4-ASO suppressed disease progression in DUX4-TG mice, extending the potential of unconjugated ASOs as a promising FSHD treatment strategy.
In vitro and in vivo Efficacies of Novel Harmine Derivatives in the Treatment of Cystic Echinococcosis

Introduction Cystic echinococcosis (CE) is a chronic zoonotic parasitic disease caused by the larvae of the Echinococcus granulosus sensu lato (s.l.) cluster. The current existing drugs have limited therapeutic efficacy against cystic echinococcosis, and thus, there is an urgent need to develop new drugs. Methods In this study, 7 harmine (HM) derivatives were screened and the effects of HM derivatives on E. granulosus sensu stricto (s.s.) were evaluated by in vitro and mouse experiments. The safety of the HM derivatives was assessed by cytotoxicity assays, acute toxicity study in animals and subacute toxicity study. Results These results show that the HM derivatives H-2-168 and DH-004 exhibited more significant antiparasitic effects at an initial concentration of 40 μM. The results of further studies showed that H-2-168 and DH-004 had dose-dependent effects against protoscoleces and had satisfactory therapeutic outcomes in vivo. Electron microscopy observations demonstrated that H-2-168 and DH-004 caused severe disruption of the parasite ultrastructure. Notably, the results of the acute toxicity and subchronic toxicity studies showed that H-2-168 and DH-004 had significantly improved safety. In addition, we found that H-2-168 and DH-004 induced DNA damage in E. granulosus s.s. , which may be the mechanism by which these drugs produce their therapeutic effects. Discussion Overall, the data from this work demonstrate that H-2-168 and DH-004 are highly effective candidate compounds with low toxicity for the treatment of CE and will provide a new therapeutic strategy for CE pharmacological treatment.
A Case-Control Study of the Relationship Between Genetic Polymorphism and Cretinism in Xinjiang

Background Cretinism is a subtype of congenital hypothyroidism, an endocrine disorder resulting from inadequate thyroid hormone production or receptor deficiency. Genetic abnormalities play a major role in the development of thyroid dysfunction. Methods We recruited 183 participants with cretinism and 119 healthy participants from the Xinjiang Uyghur Autonomous Region and randomly selected 29 tag single nucleotide polymorphisms (tSNPs) in TSHB, PAX8, TPO, NKX2-5, and TSHR in all participants. We compared genotype and allele frequencies between cases and controls utilizing the chi-squared test, logistic regression analysis, and haplotype analysis. Results Using the chi-squared test, a single SNP was found to be associated with cretinism (recessive model: rs3754363, OR = 0.46, 95% CI = 0.27–0.80, P = 0.00519; genotype model: P = 0.01677). We stratified neurological, myxedematous, and mixed type and determined that another SNP was associated with a higher risk when comparing myxedematous type to the neurological type (rs2277923). Conclusion rs3754363 has a statistically significant protective effect on people with cretinism, while rs2277923 may play a greater role in promoting the development of neurocretinism.
An Efficient Resource Block Allocation Method in Distributed MIMO

This letter derives a resource block allocation method for maximal ratio transmission in distributed multiple-input multiple-output networks. We first show that the minimum signal-to-interference-and-noise ratio of users jointly served within a time-frequency resource block is upper bounded by a quantity depending on long-term channel statistics. Inspired from the bound expression, we develop an efficient partitioning technique to distribute the users into a given number of time-frequency resource blocks so that the minimum spectral efficiency is maximized. We show that the original problem is NP-hard, and the detailed simulations verify that the proposed method provides a high-performance and low-complexity solution.
Compact Photonics-Assisted Short-Time Fourier Transform for Real-Time Spectral Analysis

A compact photonics-assisted scheme for short-time Fourier transform (STFT) is proposed and experimentally demonstrated. In the proposed scheme, a periodic chirp signal and an electrical bandpass filter (BPF) are applied to achieve a sliding window function. At the same time, the BPF is utilized to realize frequency-to-time mapping and obtain the frequency-domain information in each time window. The STFT can be realized by splicing the frequency-domain information corresponding to different time windows into a two-dimensional time-frequency graph. Experimentally, STFTs of various time-varying microwave signals are demonstrated, where a frequency resolution of 100 MHz, a time resolution of 0.1 μs, and a real-time measurement range from 1 to 9.7 GHz are separately realized. In addition, the measurement range is only limited by the bandwidth of the applied periodic chirp signal and the center frequency of the BPF. Furthermore, the proposed scheme avoids additional processing latency compared to dispersion-based STFT schemes, which ensures great real-time performance.
Content of cannabinoids in clonally propagated industrial hemp

ABSTRACT Cannabis sativa L. is an extremely variable species. Even within the same cultivar plants can significantly differ in the content and profile of cannabinoids. Therefore, the best method for production of uniform plants and standardized raw material is vegetative propagation using clones. The aim of this study was to determine the content of cannabidiolic acid (CBDA), cannabidiol (CBD), Δ9-tetrahydrocannabinolic acid (Δ9-THCA), Δ9-tetrahydrocannabinol (Δ9-THC), cannabichromene (CBC), cannabigerol (CBG), and cannabinol (CBN) in clonally propagated plants of industrial hemp. One hundred and thirty-nine plants representing 17 different hemp genotypes were regenerated in vitro, hardened, and grown in a vegetation hall until harvest. Single plants of each accession were analyzed using high-performance liquid chromatography with UV/diode-array detection (HPLC-DAD/UV). The results revealed significant variability in the total cannabinoid content (0.55–5.18% in dry weight) among tested genotypes and within the Epsilon 68 cultivar. The highest content of total CBD (4.410%) was recorded for EPS/40 genotype, while the level of total Δ9-THC was below the allowed threshold (0.3%). Therefore, we can conclude that some clonally propagated plants provided reproducible hemp material as a potential source of cannabidiol. The results of this study will be useful for breeding and early selection of hemp genotypes.
Chiroscript: Transcription System for Studying Hand Gestures in Early Modern Painting

The main goal of this article is to introduce a new method for the analysis of depicted gestures in painting, namely a transcription system called chiroscript. Based on the model of transcription and annotation systems used in linguistics of co-speech gestures and sign languages, it is intended to provide a more systematic and objective study of pictorial gestures, revealing their modes of combination inside chirographic accords. The place of chirograms (depicted hand gestures) within pictorial semiotics will be briefly discussed in order to better explain why a transcription system is very much needed and how it could expand art historical perspectives. Pictorial gestures form an understudied language-like system which has the potential to increase the intelligibility of paintings. We argue that even though transcription is not a common practice in art history, it may contribute and even transform semiotic analyses of figurative paintings.