Miracle-dz/UniFAR-FTUs huggingface dataset:
Tamaño empresarial e innovación tecnológica en la economía española

Este trabajo parte de los resultados de una encuesta sobre una muestra representativa de las empresas que han obtenido creditos del Centro para el Desarrollo Tecnologico Industrial entre 1984-1994. Se estudia las organizacion de las actividades de innovacion en funcion del tamano empresarial y se muestran las diferencias entre las pequenas, medianas y grandes empresas.
Adolescents With Asperger Syndrome and Perceptions of Friendship

This qualitative study investigated the perceptions of friendship faced by teenagers diagnosed With Asperger syndrome. This research aimed to provide teachers With an insight into the social World of Asperger syndrome from a student perspective. A multiple—case study approach Was used to collect data from 5 secondary school students in Australia. Data Were collected through the use of semistructured intervieWs. An inductive approach to data analysis resulted in a number of broad themes in the data: (a) understanding of concepts or language regarding friendships, (b) description of What is a friend, (c) description of What is not a friend, (d) description of an acquaintance, and (e) using masquerading to cope With social deficits. The insights provided by the participants in this study are valuable for teachers, parents, and anyone else involved in inclusive education.
High‐amplitude theta wave bursts characterizing narcoleptic mice and patients are also produced by histamine deficiency in mice

Histamine and orexins are wake promoters released by hypothalamic neurons. The activity of histamine neurons is increased by orexin neurons. Recently, it has been shown that orexin deficiency entails high‐amplitude theta wave bursts during rapid eye movement sleep and cataplexy in narcoleptic mice. The primary aim of this study was to assess whether histamine system is involved in high‐amplitude theta wave burst generation during rapid eye movement sleep. The secondary aim was to assess the effects of combined histamine and orexin deficiency on high‐amplitude theta wave bursts during rapid eye movement sleep in mice. Twelve histidine‐decarboxylase knockout mice with congenital histamine deficiency, seven double mutant mice with combined deficiency of orexin neurons and histamine, and 11 wild‐type control mice were studied with electrodes for sleep recordings and a telemetric blood pressure transducer. High‐amplitude theta wave bursts during rapid eye movement sleep were detected in each of the histidine‐decarboxylase knockout and double mutant mice, whereas only one burst was found in a wild‐type control mouse. High‐amplitude theta wave bursts occurred significantly more often and were significantly longer in double mutant than in histidine‐decarboxylase knockout mice. In conclusion, it was demonstrated that, similarly to orexin, the chronic impairment of histamine entailed high‐amplitude theta wave bursts during rapid eye movement sleep. The current data also suggested a synergistic role of orexin and histamine signalling on high‐amplitude theta wave bursts during rapid eye movement sleep in mice.
A soft exoskeleton suit to reduce muscle fatigue with pneumatic artificial muscles

A major issue at work sites corresponds to aging workers, and the associated back pain. In this research, we develop an assistive suit with light-weight and flexible pneumatic rubber artificial muscles to reduce muscle load. Two assist forces are designed to control the artificial muscles with PWM-control based on: 1) flexion angle, and 2) estimated torque of the hip joint. The experimental results show that the proposed suit can reduce muscle activity during bending and stretching motions.
Impulsivité et dépendances : une approche cognitive et motivationnelle à la lumière du modèle UPPS de Whiteside et Lynam

L’impulsivite apparait comme un concept central dans l’interpretation des conduites de dependance. Recemment, plusieurs auteurs ont mis en evidence que l’impulsivite etait un concept multidimensionnel. Dans cette perspective, le but de cet article est de montrer en quoi une conception multifactorielle de l’impulsivite et de ses mecanismes motivationnels et executifs sous-jacents peut contribuer a une meilleure comprehension des conduites de dependance, comportementales et en lien avec la consommation de substances.
The S-estimator in the change-point random model with long memory

This paper considers two-phase random design linear regression models. Errors and regressors are stationary long-range-dependent Gaussian processes. The regression parameters, the scale parameter and the change-point are estimated using a method introduced by Rousseeuw and Yohai [Robust regression by means of S-estimators, in Robust and Nonlinear Time Series Analysis, J. Franke, W. Hrdle, and R.D. Martin, eds., Lecture Notes in Statistics, Vol. 26, Springer, New York, 1984, pp. 256–272], which is called the S-estimator and has the property be more robust than the classical estimators in the sense that the outliers do not bias the estimation results. Some asymptotic results, including the strong consistency and the convergence rate of the S-estimator are proved. Simulations and an application to the Nile River data are also presented. It is shown via Monte Carlo simulations that the S-estimator is better than two other estimators that are proposed in the literature.
Multilingualism, citizenship, and identity: Voices of youth and symbolic investments in an urban, globalized world, by Byrd Clark, J.

Māori people and other minority groups such as migrants and their descendants from the tropical islands to the north of Aotearoa, China, and Thailand. The business mind-set of the neoliberal reformists explains the debate of the book and, although I had planned to go through the book chapter by chapter, Doerr has provided a straightforward explanation of the structure of the book between pages 21 and 23. Besides, in every chapter she introduces the ideas to be discussed and concludes with a reflection. As well, several subtitles in a chapter are useful and informative. I am not an historian, economist, or anthropologist. I am an indigenous Māori research fellow and project manager in the Faculty of Medicine and Health in the academy and, in the past, a teacher of indigenous and migrant students in the secondary school. Therefore, I can tiptoe past quite a lot of the chapters wrapped in anthropology, history, and education as a market. Indeed I pat myself on the back on being free of the malevolence of specialisation (cf. Paulo Freire). And this brings me to the disappointment that I have with the book—the editing. There are several indefinite and definite articles omitted throughout the text, as early as page 1, line 12. In the References, the title of the famous academic text written by the Māori statesman and anthropologist, Emeritus Professor Ranginui Walker, is written incorrectly (page 223, line 7). Surprisingly, the word Te reo is written as Te Rao repeatedly on page 25. So, I finish this brief review by saying that what indigenous and other minority group educators and educationalists, researchers, and the researched can draw from Meaningful Inconsistencies is indeed the wealth of cultural and political critique, supported by fieldwork, throughout the book. Therefore, I recommend highly this text to indigenous and minority group intellectuals, politicians, civil servants, other professionals, and spin doctors to improve their understanding of education as a commodity and to improve their understanding of biculturalism, citizenship, and nationhood in Aotearoa/New Zealand.
A new DNN-based high quality pronunciation evaluation for computer-aided language learning (CALL)

In this paper, we propose to use Deep Neural Net (DNN), which has been recently shown to reduce speech recognition errors sig-niﬁcantly, in Computer-Aided Language Learning (CALL) to evaluate English learners’ pronunciations. Multi-layer, stacked Restricted Boltzman Machines (RBMs), are ﬁrst trained as non-linear basis functions to represent speech signals succinctly, and the output layer is discriminatively trained to optimize the posterior probabilities of correct, sub-phonemic “senone” states. Three Goodness of Pronunciation (GOP) scores, including: the likelihood-based posterior probability, averaged frame-level posteriors of the DNN output layer “senone” nodes, and log likelihood ratio of correct and competing models, are tested with recordings of both native and non-native speakers, along with manual grading of pronunciation quality. The experimental results show that the GOP estimated by averaged frame-level posteriors of “senones” correlate with human scores the best. Comparing with GOPs estimated with non-DNN, i.e. GMM-HMM, based models, the new approach can improve the correlations relatively by 22 . 0% or 15 . 6% , at word or sentence levels, respectively. In addition, the frame-level posteriors, which doesn’t need a decoding lattice and its corresponding forward-backward computations, is suitable for supporting fast, on-line, multi-channel applications.
Distress in long-term head and neck cancer carers: a qualitative study of carers' perspectives.

AIMS AND OBJECTIVES To identify and describe the triggers of emotional distress among long-term caregivers (more than 1 year postdiagnosis) of people with head and neck cancer. BACKGROUND Limited research has been conducted on the factors that cause head and neck cancer caregivers to become distressed. DESIGN Qualitative cross-sectional. METHODS In-depth semi-structured interviews. Interviews were conducted via telephone. The study setting was the Republic of Ireland. RESULTS Interviews were conducted with 31 long-term caregivers (mean time since diagnosis 5·7 years, SD 2·9 years). Head and neck cancer caregivers experienced significant distress. Six key triggers of emotional distress were identified: understandings and fears of illness, lifestyle restrictions and competing demands, facial disfigurement, financial problems, comorbid health problems and witnessing suffering. Cutting across all of these individual causes of distress was a strong feeling of loss caused by head and neck cancer. CONCLUSIONS Some head and neck cancer caregivers became considerably distressed by their caring role. Although distress appears to decline with time for many caregivers, some continue to be distressed for years following the patient's diagnosis. It would be useful for future research to explicitly investigate caregivers' experiences of loss. RELEVANCE TO CLINICAL PRACTICE Health professionals may be able to reduce distress in this group if they can help caregivers to access resources that can be used to buffer financial problems. Health professionals may also be able to reduce distress if they can work with caregivers to help them to obtain something of personal value or significance from their experience of loss and suffering.
The manager’s role in coaching Overcoming barriers to success

Traditional approaches to managing people simply do not work. Being directive, i.e. “I tell you what to do and when to do it” inhibits development of the individual over time. Staff continually instructed by overly directive managers do not blossom, they wither. When we tell staff how to do everything, we are actually teaching them to do less for themselves.
ON THE ECOLOGICAL BASIS OF INTERSPECIFIC HOMOPLASY IN CAROTENOID-BEARING SIGNALS

Abstract Evidence that similar color patterns occur in unrelated animals with different habits undermines the traditional view that homoplasy evolves through shared ecological selection pressures. Carotenoid pigments responsible for many yellow to red signals exhibit two related properties that could link ecology with appearance by nontraditional means. Ecologic homoplasy could arise through ecophenotypy because all animals must obtain carotenoids through their diet. Such homoplasy also could be hidden from view because increased carotenoid levels are more strongly encoded by decreased reflectance over ultraviolet (UV) wavelengths invisible to humans. To explore these possibilities, I examined apparent matches or mismatches between color and ecology among insectivorous (low carotenoid diet) and frugivorous (high carotenoid diet) bird species in relation to the typical yellow and black plumage pattern of insectivorous, UV-sensitive titmice (Paridae). Diagnostic features of reflectance spectra indicated that all yellow plumages resulted from carotenoids, black plumages from melanins, and olive green plumages from codeposition of both pigments. However, reflectance by carotenoid-bearing plumages correlated with diet independent of plumage pattern; compared to the insectivores, frugivores had reduced amounts of UV reflectance, and to a lesser extent, “red shifts” in longer-wavelength reflectance. Furthermore, an asymptotic decrease in amount of UV with increased redness implied that plumage reflectance of insectivorous species differed more over UV wavelengths, whereas that of frugivorous species differed more over longer wavelengths. I verified that dietary links to plumage reflectance resulted from greater amounts of plumage carotenoids in frugivores, presumably due to their carotenoid-rich diets. All of these ecological associations transcended post-mortem or post-breeding color change, and phylogeny. Thus, predictable associations between avian-visible plumage reflectance, pigmentation, and diet across evolutionary scales may arise directly (diet per se) or indirectly (honest signaling of diet) by ecophenotypy, although various genetic factors also may play a role.
Porphyromonas gingivalis Uses Specific Domain Rearrangements and Allelic Exchange to Generate Diversity in Surface Virulence Factors

Porphyromonas gingivalis is a keystone pathogen of chronic periodontitis. The virulence of P. gingivalis is reported to be strain related and there are currently a number of strain typing schemes based on variation in capsular polysaccharide, the major and minor fimbriae and adhesin domains of Lys-gingipain (Kgp), amongst other surface proteins. P. gingivalis can exchange chromosomal DNA between strains by natural competence and conjugation. The aim of this study was to determine the genetic variability of P. gingivalis strains sourced from international locations over a 25-year period and to determine if variability in surface virulence factors has a phylogenetic basis. Whole genome sequencing was performed on 13 strains and comparison made to 10 previously sequenced strains. A single nucleotide polymorphism-based phylogenetic analysis demonstrated a shallow tri-lobed phylogeny. There was a high level of reticulation in the phylogenetic network, demonstrating extensive horizontal gene transfer between the strains. Two highly conserved variants of the catalytic domain of the major virulence factor the Kgp proteinase (KgpcatI and KgpcatII) were found. There were three variants of the fourth Kgp C-terminal cleaved adhesin domain. Specific variants of the cell surface proteins FimA, FimCDE, MfaI, RagAB, Tpr, and PrtT were also identified. The occurrence of all these variants in the P. gingivalis strains formed a mosaic that was not related to the SNP-based phylogeny. In conclusion P. gingivalis uses domain rearrangements and genetic exchange to generate diversity in specific surface virulence factors.
Similarities between texture grouping and motion perception: The role of color, luminance, and orientation

We present a series of experiments whose results show strong similarities between textural grouping and motion experiments. A family of stimuli consisting of elements of different colors, luminance‐polarity, and orientation are used in experiments in both eliciting textural grouping and detection of apparent motion. Among the similarities are that the orientation attribute is a weaker attribute than either color or luminance polarity in eliciting both textural grouping and in detection of apparent motion. However, if the orientation elements are collinear they become salient and contribute toward grouping and apparent motion. The results also indicate that chromatic mechanisms play a significant role in both texture and motion perception. The similarity suggests that perceptual rules governing spatial grouping are analogous to those governing spatiotemporal grouping. The results of these experiments could be used in the areas of image segmentation, pattern recognition, and scientific visualization. © 1996 John Wiley & Sons, Inc.
Nondisjunction Mutants of the Nematode CAENORHABDITIS ELEGANS.

The frequency of males (5AA; XO) among the self progeny of wild-type Caenorhabditis elegans hermaphrodites (5AA; XX) is about one in 500. Fifteen him (for "high incidence of males") mutations have been identified that increase this frequency by a factor of ten to 150, as a result of increased X-chromosome nondisjunction. The mutations define ten complementation groups, which have been mapped: nine are autosomal, and one sex linked. Most of the mutants are superficially wild type in anatomy and behavior; however, him-4 mutants display gonadal abnormalities, and unc-86 mutants, which have a Him phenotype, exhibit a variety of anatomical and behavioral abnormalities. All the mutants segregate fertile 3X hermaphrodite progeny as well as XO male progeny. Some produce large numbers of inviable zygotes. Mutants in all ten genes produce diplo-X and nullo-X exceptional ova, and in the four strains tested, diplo-X and nullo-X exceptional sperm are produced by 2X "transformed" males. It appears likely that most of the mutants have defects in both gamete lines of the hermaphrodite. XO males of him strains other than him-4 and unc-86 are similar to wild-type males in anatomy and behavior, and all produce equal or almost equal numbers of haplo-X and nullo-X sperm, and no diplo-X sperm. Male fertility is reduced to varying extents in all him mutants. In four of the strains, nondisjunction during oogenesis has been shown to occur at a reductional division, and in three of these strains, abnormalities in recombination have been demonstrated. One mutant also exhibits autosomal nondisjunction, but many of the others probably do not. Therefore, the X chromosome of C. elegans may differ from the autosomes in the mechanisms controlling its meiotic behavior. --3X hermaphrodites are shorter and less fertile than 2X hermaphrodites, and they produce many inviable zygotes among their self progeny: these are probably 4X zygotes. Haplo-X and diplo-X ova are produced in 2:1 ratio by 3X hermaphrodites. him mutations are expressed in these animals, increasing the frequency of self-progeny males and 2X hermaphrodites.
Conformal and fractional boundary states in the symmetric orbifold of the level one SU ( 2 ) WZW model

We study the space of the allowed boundary states in a particular c = 1 conformal field theory, the symmetric orbifold of the level one SU(2) WZW model, where the orbifolding group G is a generic binary finite subgroup of SU(2). We especially construct generic boundary states in the orbifold, which can be extended from the Cardy states decomposed into Virasoro Ishibashi states. Our result involves conformal boundary states parameterized by the quotient SU(2)/G, and the fractional boundary states sitting at every fixed-point in the quotient. We find also that a conformal boundary state at a fixed-point in the quotient becomes a linear combination of the fractional boundary states sitting at the fixed-point. To be complete, we check the mutual consistency among all the boundary states we construct.
Update on Ethylene Signal Transduction Mechanistic Insights in Ethylene Perception and Signal Transduction 1

The gaseous hormone ethylene profoundly affects plant growth, development, and stress responses. Ethylene perception occurs at the endoplasmic reticulum membrane, and signal transduction leads to a transcriptional cascade that initiates diverse responses, often in conjunction with other signals. Recent findings provide a more complete picture of the components and mechanisms in ethylene signaling, now rendering a more dynamic view of this conserved pathway. This includes newly identified protein-protein interactions at the endoplasmic reticulum membrane, as well as the major discoveries that the central regulator ETHYLENE INSENSITIVE2 (EIN2) is the long-sought phosphorylation substrate for the CONSTITUTIVE RESPONSE1 protein kinase, and that cleavage of EIN2 transmits the signal to the nucleus. In the nucleus, hundreds of potential gene targets of the EIN3 master transcription factor have been identified and found to be induced in transcriptional waves, and transcriptional coregulation has been shown to be a mechanism of ethylene cross talk.
Prognosis of metastatic renal cell carcinoma with first‐line interferon‐α therapy in the era of molecular‐targeted therapy

The RCC‐SELECT study showed the correlation between single nucleotide polymorphisms (SNP) in STAT3 gene and survival in metastatic renal cell carcinoma (mRCC) patients with first‐line interferon‐α (IFN‐α). In that study, even patients with STAT3 SNP linked to shorter overall survival (OS) exhibited remarkably improved prognosis. All 180 patients evaluated in the above study were further analyzed for correlation between OS and demographics/clinicopathological parameters. OS was estimated using the Kaplan–Meier method. Associations between OS and potential prognostic factors were assessed using the log‐rank test and the Cox proportional hazards model. The median OS was 42.8 months. Univariate analysis showed that worse Eastern Cooperative Oncology Group‐performance status (ECOG‐PS), high T stage, regional lymph node metastasis, distant metastasis, higher grade, infiltrative growth pattern, the presence of microscopic vascular invasion (MVI), hypercalcemia, anemia, thrombocytopenia and elevated C‐reactive protein were significantly associated with OS. Multivariate analysis revealed that ECOG‐PS (hazard ratio [HR] = 3.665, P = 0.0004), hypercalcemia (HR = 6.428, P = 0.0005) and the presence of MVI (HR = 2.668, P = 0.0109) were jointly significant poor prognostic factors. This is the first study analysing prognostic factors of mRCC patients with first‐line IFN‐α using large cohort of the prospective study. The present study suggests that first‐line IFN‐α is still a useful therapy for mRCC even in the era of molecular targeted therapy.
Comparative of Physical Complaints, Depression and OCD in People with Hearing Impaired and Normal People in Ahwaz “Iran”

Hearing is an important sense. Some parts of our communication with the outside world are based on this sense. Those who are deaf from birth cannot acquire language. Social reactions and the type of behaviors with that people who are faced and also showing sympathy to them or blaming them is some causes of mood disorders among these people. This study sought to compare the psychological disorders of people having normal hearing and those suffering from hearing loss in Ahwaz. Method: This study has a comparative nature. Participants of this study were 40 normal-hearing and 40 people who suffered from hearing loss. The data were collected on the basis of SCL-90-R1 questionnaire, which is one of the most-applied questionnaires in psychiatry, and a demographic questionnaire. Results: The findings of this study showed an observable difference between people having normal hearing and those who suffer from hearing loss in terms of psychological disorders for instance (physical problems, depression, obsessive-compulsive disorder). The results showed that such disorders are more common among people who suffer from hearing loss. Conclusion: There are meaningful differences between people who have normal hearing and those suffering from hearing impaired in terms of all main variables of the study.