Miracle-dz/UniFAR-FTUs huggingface dataset:
An intellectual-disability-associated mutation of the transcriptional regulator NACC1 impairs glutamatergic neurotransmission

Advances in genome sequencing technologies have favored the identification of rare de novo mutations linked to neurological disorders in humans. Recently, a de novo autosomal dominant mutation in NACC1 was identified (NM_052876.3: c.892C > T, NP_443108.1; p.Arg298Trp), associated with severe neurological symptoms including intellectual disability, microcephaly, and epilepsy. As NACC1 had never before been associated with neurological diseases, we investigated how this mutation might lead to altered brain function. We examined neurotransmission in autaptic glutamatergic mouse neurons expressing the murine homolog of the human mutant NACC1, i.e., Nacc1-R284W. We observed that expression of Nacc1-R284W impaired glutamatergic neurotransmission in a cell-autonomous manner, likely through a dominant negative mechanism. Furthermore, by screening for Nacc1 interaction targets in the brain, we identified SynGAP1, GluK2A, and several SUMO E3 ligases as novel Nacc1 interaction partners. At a biochemical level, Nacc1-R284W exhibited reduced binding to SynGAP1 and GluK2A, and also showed greatly increased SUMOylation. Ablating the SUMOylation of Nacc1-R284W partially restored its interaction with SynGAP1 but did not restore binding to GluK2A. Overall, these data indicate a role for Nacc1 in regulating glutamatergic neurotransmission, which is substantially impaired by the expression of a disease-associated Nacc1 mutant. This study provides the first functional insights into potential deficits in neuronal function in patients expressing the de novo mutant NACC1 protein.
A conditional random field model for name disambiguation in National Natural Science Foundation of China fund

The name ambiguity problem affects the accuracy of the web search, document retrieval, and information fusion. A lot of work has been done to solve the name disambiguation problem for publication or paper, but we propose a model to solve this problem for the National Natural Science Foundation of China fund. In this paper, we propose a probabilistic Markov random fields framework to solve the problem of the National Natural Science Foundation of China fund name disambiguation. We define an objective function and use parameters learning algorithm to get the suitable parameters. Experimental results indicate that our approach significantly outperforms other different traditional clustering methods.
“LOS NUEVOS, NUEVOS OBJETOS” Y LA MATERIALIDAD DE LA INVESTIGACIÓN DE LA CULTURA DIGITAL EN AMÉRICA LATINA. ENTREVISTA AL DR. CARLOS SCOLARI

Doctor en Lingüística Aplicada y Lenguajes de la Comunicación (Università Sacro Cuore di Milano) y Catedrático en Teoría y Análisis de la Comunicación Digital Interactiva del Departamento de Comunicación en la Universitat Pompeu Fabra - Barcelona. Sus investigaciones se han centrado en la nueva ecología/evolución de los medios, las interfaces y las narrativas transmedia. Entre otras obras ha publicado: Hacer Clic (2004), Hipermediaciones (2008), El fi n de los medios (con M. Carlón, 2009/12), Crossmedia Innovations (con I. Ibrus, 2012), Narrativas Transmedia (2013), Transmedia Archaeology (con P. Bertetti y M. Freeman, 2014), Ecología de los Medios (2015), Las Leyes de la Interfaz (2018) y Media Evolution (2019). Sus artículos han sido publicados en Communication Th eory, New Media & Society, International Journal of Communication, Semiotica, Information, Communication & Society, Convergence, Comunicación y Sociedad, Palabra Clave, entre otras revistas científi cas. Investigador Principal del proyecto H2020 TRANSLITERACY (2015-18), TRANSALFABETISMOS (2015-18) y PLATCOM (2020-23). Desde 2018 es coordinador del programa de Doctorado en Comunicación en la UPF.
Does Trust Beneficiary Protection Affect the Performance of Trust Companies? An Analysis Based on the Theory of Law and Finance

Trust beneficiary protection constitutes an important legal system in the trust industry. This paper, based upon the study approach of the “Theory of Law and Finance”, establishes the trust beneficiary protection index of China. We also test the influence of trust beneficiary protection on the performance of trust companies. As indicated by our study’s results, an “inverted U-shaped” relationship exists between the degree of trust beneficiary protection and the performance of trust companies. In a period when the trust law system has not yet been well established, strengthening trust beneficiary protection could help facilitate the growth of trust company performance. However, this facilitation effect gradually diminishes as the trust law system becomes more perfect. This in turn means that, after reaching a certain peak, conferring the beneficiary with more rights of supervision and participation would cause the performance of trust companies to decline. Improving regional legal environments could also help facilitate the growth of trust company performance. In addition, this facilitation effect is subject to the influence of the nature of trust company controllers. In trust companies controlled by local state-owned capitals, we find that the facilitation effect of the improvement of regional legal environments on trust company performance is inhibited. In trust companies controlled by non-state-owned capitals, however, the facilitation effect of the improvement of regional legal environments on trust company performance is enhanced.
Simple Model and PI Controller to Improve the Performance Characteristics of PMSM under Field Oriented Control with Using SVPWM

— Voltage source inverter is widely used in many industrial applications such as robot, electric vehicle and machine tool. The performance of the drive system depends upon the method of control for converter and motor control method. From the most performance method is a space vector pulse width modulation technique. Here the field oriented control of permanent magnet synchronous motor with using space vector modulation is used to controlling the inverter and improving the performance characteristics of the motor such as speed, currents and the electric torque by reducing their ripples. This occurs through adding PI controller for flux and simple model to track the torque and speed when varying load is applied. In the PI controller, the d-axis flux is compared to rotor permanent magnet flux to solve the problem arises from non-sinusoidal of the magnetic flux. The output of the PI controller is added to the reference d-axis current. The new d-axis current will reach the best value of THD. The simple model is used to generate new q axis torque current controller comes from lookup table and adding to reference q axis current controller to control the motor speed. The effect of improvement can be seen through the torque ripples, THD and motor speed. This work is simulated by matlab simulink.
Effects of dietary polyphenol curcumin supplementation on metabolic, inflammatory, and oxidative stress indices in patients with metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials

Objective The aim was to conduct a systematic review and meta-analysis for assessing the effectiveness and safety of dietary polyphenol curcumin supplement on metabolic, inflammatory, and oxidative stress indices in patients with metabolic syndrome (MetS). Methods A comprehensive search for clinical trials was conducted in the following scientific databases: PubMed, SCOPUS, Cochrane Library, EMBASE, Web of Science, and China Biological Medicine. Randomized controlled trials (RCTs) evaluating the efficacy and safety of curcumin supplement for MetS were identified. A random-effects meta-analysis was performed using inverse variance, and efficacy was expressed as mean difference (MD) with 95% confidence interval (CI). The metabolic syndrome markers that were evaluated in the present study included waist circumference (WC), fasting blood sugar (FBS), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), tumor necrosis factor-a (TNF-a), interleukin 6 (IL-6), C-reactive protein (CRP), ultrasensitive c-reactive protein (hsCRP), and malondialdehyde (MDA). By employing the Cochrane tool, RCTs were assessed for bias risk. Results A total of 785 participants from 13 RCTs were included, with intervention durations ranging from 4 to 12 weeks. Compared with the control group, the curcumin group had positive effects on WC (MD = -2.16, 95% CI: -3.78 to -0.54, p = 0.009, seven studies), FBS (MD = -8.6, 95% CI: -15.45 to -1.75, p = 0.01, nine studies), DBP (MD = -2.8, 95% CI: -4.53 to - 1.06, p = 0.002, five studies), HDL-C (MD = 4.98, 95% CI: 2.58 to 7.38, p < 0.0001, eight studies), TNF-a (MD = -12.97, 95% CI: -18.37 to -7.57, p < 0.00001, two studies), CRP (MD = - 1.24, 95% CI: -1.71 to -0.77, p < 0.00001, two studies), and MDA (MD = -2.35, 95% CI: -4.47 to -0.24, p = 0.03, three studies). These improvements were statistically significant. Meanwhile, there was no significant improvement in SBP (MD = -4.82, 95% CI: -9.98 to 0.35, p = 0.07, six studies), TG (MD = 1.28, 95% CI: -3.75 to 6.30, p = 0.62, eight studies), IL-6 (MD = -1.5, 95% CI: -3.97 to 0.97, p = 0.23, two studies), or hsCRP (MD = -1.10, 95% CI: -4.35 to 2.16, p < 0.51, two studies). FBS, SBP, HDL-C, IL-6, CRP, hsCRP, and MDA had a relatively high heterogeneity. Conclusion Curcumin exhibited promising potential in enhancing markers associated with metabolic syndrome, including inflammation. However, additional studies are required to confirm such findings since the included evidence is limited and has a relatively high heterogeneity. Systematic review registration https://www.crd. york.ac. uk/prospero, identifier CRD42022362553.
Synchronization of heterogeneous harmonic oscillators for generalized uniformly jointly connected networks

The synchronization problem for heterogeneous harmonic oscillators is investigated. In practice, the communication network among oscillators might suffer from equipment failures or malicious attacks. The connection may switch extremely frequently without dwell time, and can thus be described by generalized uniformly jointly connected networks. We show that the presented typical control law is strongly robust against various unreliable communications. Combined with the virtual output approach and generalized Krasovskii-LaSalle theorem, the stability is proved with the help of its cascaded structure. Numerical examples are presented to show the correctness of the control law.
Theory and Methodology Network distance characteristics that aÄect computational eÄort in p-median location problems

In solving location models, the eAort expended and the quality of the solutions obtained often varies significantly from one problem instance to another. Our conjecture is that this is not a random occurrence but, instead can be correlated with characteristics of the network upon which the model is constructed. In this paper, we examine a variety of approaches for generating networks for the p-median model. The types of networks studied include those based on Euclidean inter-point distances, shortest paths developed from a predefined network, and randomly generated distance matrices. In addition to the process by which the network is constructed, we consider the distribution of distances, symmetry and the satisfaction of the triangle inequality. All of these characteristics influence the eAort required to solve the p-median model. We have found, however, that the triangle inequality has the most significant impact. ” 2000 Elsevier Science B.V. All rights reserved.
Histopathological differences between vitiligo and lichen sclerosus et atrophicus using quantitative immunohistochemical analysis

Introduction Lichen sclerosus et atrophicus (LS) is rare skin condition characterized by the presence of whitish patches primarily affecting the genital and perianal areas, though it can occur other parts of the body. LS may result in skin depigmentation without textural changes and should be differentiated from vitiligo. However, the histopathological features of hypopigmentation during vitiligo and LS have rarely been compared and have not been precisely described using quantitative immunohistochemical analysis. This study, therefore, aimed to investigate and compare the pigmentary characteristics of LS and vitiligo lesions using histochemical and immunohistochemical staining. Methods We included 31 and 46 patients diagnosed with LS and vitiligo, respectively, at Ajou University Hospital between March 2009 and March 2020 in this study. Their medical charts and skin biopsy specimens were retrospectively reviewed. Additionally, Fontana–Masson staining for melanin and immunohistochemical staining for Melan-A, NKI/beteb, tyrosinase, and microphthalmia-associated transcription factor was performed. Results The melanin content, as well as the number of melanocytes was, in general, significantly higher in the epidermis of patients in the LS group compared with that in the vitiligo group. However, 22.6% of LS tissues showed less melanin pigmentation, 25.8% of LS specimens exhibited a lower number of melanocytes, and 29.0% of LS specimens demonstrated less melanocyte activity when compared with the average of vitiligo specimens. Conclusion As lower melanin pigmentation and the near absence number of melanocytes were also observed in several LS specimens, both the clinical and histological findings must be comprehensively reviewed to differentiate vitiligo from LS.
Numerical simulation of motions of ship with moonpool in head waves

The paper shows the results of assessing the possibilities of computational fluid dynamics for predicting the motions of a ship with a moonpool and vertical water motions in a moonpool in regular head waves with a zero ship speed. A moonpool is a well which is used in different types of ships such as cable laying, drill and FPSO, survey, research and so on. This well is used for launching and lifting of different devices, divers, rescue bells, cables and risers, which are protected from outboard wind and waves. The results of the numerical simulation in the OpenFOAM software of heave and pitch motions of the DTMB 5415 model in regular head waves with and without ship speed show good agreement with the experimental data. The experiment was organized with a series 60 model, which was equipped with different moonpool shapes modules in regular head waves with a zero ship speed for determining heave and pitch RAOs and vertical water motions in the moonpool. The results do not show any influence of the moonpool for heave and pitch ship motions. These data are necessary for numerical simulation verification. The results of the numerical simulation of experimental research show good agreement, which means the good efficiency of computational fluid dynamics in heave and pitch motions and vertical water motions in moonpool calculation of a ship with a moonpool. Numerical simulation should be advised for calculations during the ship design process.
Using British Literature to Teach Empathy to the Chinese University Students Majoring in English Language

This paper aimed to strengthen Chinese University English Majors’ (CUEMs) capability in understanding, analyzing, and appreciating British Literature. This research focuses on the effective pedagogy applied to make CUEMs compassionate and empathetic. The participants were 65 students who are in their third year of study at the School of Foreign Languages, in Sichuan University of Science & Engineering, a Chinese University, therefore they can sympathize with feelings and emotions expressed by British authors, showing mastery of British literary writings. Facing exotic literature, CUEMs usually feel perplexed and stressed, then they give the cold shoulder to the course as well their teaching staff. The empathy empowerment program adopted a qualitative research design, acquiring textual data gained from the learners who were asked to hand in their essays particularly assigned by the researcher to perceive whether the learners become empathetic after learning some British literary writings. After the collected data were coded and analyzed, the program testified that learners become empathetic after taking British literature classes through thematic analysis. This research can be valuable for literature academics both in and outside of China who are frequently confused, helpless, and even frustrated in teaching literature and are eager to get more responses from their learners in class by learning to assign meaningful and thought-provoking, empathy-arousing essay questions highly associated with literary texts to their
Extremely stable temperature characteristics of 1550-nm band, p-doped, highly stacked quantum-dot laser diodes

We fabricated 1.55-µm band, broad-area, p-doped, 30-layer stacked quantum-dot (QD) laser diodes (LDs) grown on an InP(311)B substrate via a delta-doping method employing a strain compensation technique. We doped Be atoms to a depth of 5 nm from the bottom of each QD layer. The concentration of Be atoms doped in the InGaAlAs spacer layer was 1 × 1018 cm−3. We observed a strong photoluminescence emission and a relatively coherent surface of QDs using atomic force microscopy. In addition, we observed that the fabricated QD-LDs had extremely stable temperature characteristics, and a characteristic temperature T0 of more than 2156 K was obtained.
Adaptive state feedback controller design for a rotary series elastic actuator

The design of human assistive systems requires actuators that are capable of producing compliant motions. One key technological development for this compliant actuation is series elastic actuation, which is a challenging design problem, as the load side dynamics of the actuator changes during operation. In this paper, a novel series elastic actuator (SEA) structure using composite beams as series elastic elements and its torque control strategy are presented. We proposed a two-stage controller, a novel adaptive state feedback controller for transient dynamics and a PI controller for eliminating steady-state error. The effect of disturbance torque is studied, together with load dynamics, which is estimated online by a recursive least square method. The performance of the actuator was evaluated in case studies in which the actuator was controlled with various knee torque profiles. The experimental results showed that desired dynamic behaviour of the designed SEA can be obtained with the proposed control algorithm despite the unknown load dynamics.
A Principle Discussion of Edge Detection based on Gaussian Wavelet

Edge detection is an image processing technique for finding the boundaries of objects within images. It works by detecting discontinuities in brightness. In this paper, we develop the Canny edge detector, introduce wavelet basis functions of nth Gaussian derivative and utilize them to extract the edge. At first, the principle of the edge detection by the wavelet transform is given briefly and new basis of wavelet functions are introduced and admissibility conditions of them are discussed. Then, the theoretical edge detection analysis of three significant edge types (step, ramp and stage) via new wavelet basis functions is studied, and relevant formulas are derived. The theory of the step response in the x, y and arbitrary direction is given and the effect of smoothing filter is obtained. We show that all introduced wavelet functions can detect the breakpoint of the step function. A model of the ramp function is presented and an approximation of it is used to simplify the results
Associations of meditation with telomere dynamics: a case–control study in healthy adults

Introduction Telomeres are protective end caps of chromosomes which naturally shorten with each cell division and thus with age. Short telomeres have been associated with many age-related diseases. Meditation has come to the fore as a mind–body practice which could influence the telomere dynamics underlying these phenomena. We previously reported meditation to be associated with higher telomerase levels, mindfulness and quality of life. Here, reporting on the same study population, we describe associations between long-term meditation and telomere length (TL), expression of hTERT and hTR genes and methylation of the promoter region of hTERT gene. Methods Thirty healthy meditators and matched non-meditators were recruited. TL was measured using quantitative PCR, gene expression was assessed using reverse transcriptase PCR, and methylation level was quantified by bisulfite-specific PCR followed by Sanger sequencing. Comparisons between meditators and controls were carried out using t-tests, while Pearson correlation was used to identify correlations, and regression was used to identify predictors. Results Males comprised 63.4% of each group with an average age of 43 years. On average, they had meditated daily for 5.82 h (±3.45) for 6.8 years (±3.27). Meditators had longer relative TLs (p = 0.020), and TL decreased with age (p < 0.001) but was not associated with other socio-demographic variables. Regression analysis showed that age (p < 0.001) and duration of meditation (p = 0.003) significantly predicted TL. The meditators showed higher relative expression of hTERT (p = 0.020) and hTR (p = 0.029) genes while the methylation level of the promoter region of hTERT gene was significantly lower when compared to non-meditators (p < 0.001). Negative correlations were identified between the methylation level of the promoter region of hTERT gene and the expression of the hTERT gene (p = 0.001) and duration of meditation (p = 0.001). Conclusion The findings suggest that meditation as a lifestyle practice has multi-level beneficial effects on telomere dynamics with potential to promote healthy aging.
Dynamics of knowledge-intensive production: An agency-structure framework

ABSTRACT In the vast majority of modern technological and knowledge-intensive production systems, human agency and the structure of social interactions among the human individuals are implicated in each other. While the force of agency drives an individual’s urge to introduce innovation and novelty into production, the force of the structuring interactions demands shared expectations and mutual adaptation for co-creation. In an organizational context, when the objective is to manage production work that is governed by the concurrent interplay of both these forces, one might ask whether the cumulative output of each could be reconciled through the emergence of a stable balance between them over time. In this article, I introduce a framework to study the conditions under which this balance can be attained. Based on a real-life application, I show, in particular, that, while a direct realization of the condition is unlikely in practice, it is possible, nevertheless, to establish indirectly the condition through adjustments of certain parameters relevant to the dynamics of a networked system. The work contributes to the growing body of literature that explores the role of coordination between self-driven activities of individuals and their structure-mediated interactions in an underlying social context.