Miracle-dz/UniFAR-FTUs huggingface dataset:
Gas exchange, metabolite status and excess post-exercise oxygen consumption after repetitive bouts of exhaustive exercise in juvenile rainbow trout.

Juvenile rainbow trout (approximately 6 g) were exercised to exhaustion in two 5 min bouts given 6 h apart. Resting levels of whole-body lactate and glycogen were restored prior to the second bout. The rate of O2 consumption increased about threefold 5 min after each bout of exercise, while recovery time decreased from 4 h after the first bout to 2-3 h after the second. The excess post-exercise oxygen consumption, i.e. 'oxygen debt', was significantly reduced by 40% after the second exercise bout, despite almost identical rates of lactate clearance and glycogen resynthesis. The rates of CO2 and ammonia excretion increased sixfold and threefold, and recovery times decreased from 4-6 h to 3 h and from 3 h to 1.5 h, respectively. After the first bout, whole-body lactate levels peaked at 5 min post-exercise at about 8.5 times pre-exercise levels. After the second bout, lactate levels peaked at 0 min post-exercise and fell more rapidly during recovery. Whole-body glycogen levels decreased by 70% and 80% and ATP levels decreased by 75% and 65% after the first and second bouts, respectively, while glucose levels increased about 1.5-fold immediately after both bouts. Creatine phosphate levels decreased by 70% and 80% after the first and second bouts, respectively. After 6 h of recovery, creatine phosphate levels were higher after the second bout than after the first. These findings suggest that exhaustive exercise may cause a 'non-specific' increase in metabolic rate not directly related to the processing of metabolites, which is reduced upon a subsequent exercise bout. This is in contrast with the classical 'oxygen debt hypothesis', which states that the oxygen debt and lactate clearance are linked. Furthermore, it appears that two sequential exercise bouts are sufficient to induce a 'training effect', i.e. improved rates of metabolic recovery.
A novel strategy for cartilage tissue engineering: Collagenase-loaded cryogel scaffolds in a sheep model

ABSTRACT In this study, we developed a novel strategy, through which cartilage tissue pieces were placed in a sheep cartilage defect model and covered with a collagenase incorporated cryogel scaffold (in vivo cartilage tissue engineering, IVCTE group). While applying this strategy, the chondrocytes could be isolated inside the body and the treatment could be accomplished in one session. To compare our strategy, to another group, in which we used cultured cells and Chondro-gide, standard matrix-induced autologous chondrocyte implantation (MACI) was applied. Although the MACI applied group demonstrated better healing than IVCTE, the type II collagen synthesis was better in the IVCTE group compared to MACI applied group. Collagenase did not have detrimental effect on surrounding cartilage in IVCTE group. The preliminary results of the novel strategy applied group (IVCTE) were promising. GRAPHICAL ABSTRACT
Fitting Characteristics of Eighteen N95 Filtering-Facepiece Respirators

Four performance measures were used to evaluate the fitting characteristics of 18 models of N95 filtering-facepiece respirators: (1) the 5th percentile simulated workplace protection factor (SWPF) value, (2) the shift average SWPF value, (3) the h-value, and (4) the assignment error. The effect of fit-testing on the level of protection provided by the respirators was also evaluated. The respirators were tested on a panel of 25 subjects with various face sizes. Simulated workplace protection factor values, determined from six total penetration (face-seal leakage plus filter penetration) tests with re-donning between each test, were used to indicate respirator performance. Five fit-tests were used: Bitrex™, saccharin, generated aerosol corrected for filter penetration, PortaCount® Plus corrected for filter penetration, and the PortaCount Plus with the N95-Companion™ accessory. Without fit-testing, the 5th percentile SWPF for all models combined was 2.9 with individual model values ranging from 1.3 to 48.0. Passing a fit-test generally resulted in an increase in protection. In addition, the h-value of each respirator was computed. The h-value has been determined to be the population fraction of individuals who will obtain an adequate level of protection (i.e., SWPF ≥ 10, which is the expected level of protection for half-facepiece respirators) when a respirator is selected and donned (including a user seal check) in accordance with the manufacturer's instructions without fit-testing. The h-value for all models combined was 0.74 (i.e., 74% of all donnings resulted in an adequate level of protection), with individual model h-values ranging from 0.31 to 0.99. Only three models had h-values above 0.95. Higher SWPF values were achieved by excluding SWPF values determined for test subject/respirator combinations that failed a fit-test. The improvement was greatest for respirator models with lower h-values. Using the concepts of shift average and assignment error to measure respirator performance yielded similar results. The highest level of protection was provided by passing a fit-test with a respirator having good fitting characteristics.
Drugs , hERG and sudden death

Early recognition of potential QT/TdP liability is now an essential component of the drug discovery/drug development program. The hERG assay is an indispensable step and a high-quality assay must accompany any investigational new drug (IND) application. While it is the gold standard at present, the hERG assay is too labor-intensive and too low throughput to be used as a screen early in the discovery/development process. A variety of indirect high throughput screens have been used. © 2004 Elsevier Ltd. All rights reserved.
Electromagnetic production of kaons.

Employing diagrammatic techniques, a model for the reactions /sup 1/H(.gamma.,K/sup +/). lambda. and /sup 1/H(e,e'K/sup +/). lambda. is derived with the coupling constants being determined phenomenologically by a least-squares fit to the available data. We find a strong sensitivity of the photoproduction process to t-channel exchange terms. The inclusion of the kaon resonance Q1(1280 MeV) brings the dominant K.lambda. N coupling constant in agreement with predictions from the analysis of Kp scattering data. An excellent fit to the electroproduction data confirms former measurements of the kaon radius.
A Tractable Model of Precautionary Reserves, Net Foreign Assets, or Sovereign Wealth Funds

We model the motives for residents of a country to hold foreign assets, including the precautionary motive that has been omitted from much previous literature as intractable. Our model captures many of the principal insights from the existing specialized literature on the precautionary motive, deriving a convenient formula for the economy's target value of assets. The target is the level of assets that balances impatience, prudence, risk, intertemporal substitution, and the rate of return. We use the model to shed light on two topical questions: The 'upstream' flows of capital from developing countries to advanced countries, and the long-run impact of resorbing global financial imbalances.
De novo t(X;21) (q28;ql 1) in a girl with phenotypic features of Williams-Beuren syndrome

We describe a female infant with mental retardation and some of the phenotypic features of Williams-Beuren syndrome. Chromosome analysis showed t(X;21) (q28;qll). Diagnosis, inactivation of the X chromosome, and possible involvement of the translocation breakpoints in the pathogenesis of this syndrome are discussed. (J Med Genet 1992;29:747-9) Williams-Beuren syndrome (WBS) is characterised by peculiar facial features, mental retardation, hypercalcaemia, and supravalvular aortic stenosis (SVAS) or peripheral pulmon-ary artery stenosis. '2 However, cardiovascular features and hypercalcaemia are not always present.35 To our knowledge, four chromosomal abnormalities have been described in WBS:
Quantifying the Effect of Guard Rings and Guard Drains in Mitigating Charge Collection and Charge Spread

3D-TCAD simulations in a 130-nm process are used to show the effect of guard rings and guard drains in mitigating charge collection and charge sharing between nodes. Experimental results quantifying the reduction in SET pulse width and the error cross section were obtained with the use of SET pulse width and SET error rate measurement test circuits fabricated in 130-nm and 180-nm processes. Results indicate that guard drains results in 30% lower error cross section compared to guard ring circuits.
Cloning and nucleotide sequences of the genes encoding triose phosphate isomerase, phosphoglycerate mutase, and enolase from Bacillus subtilis

The Bacillus subtilis genes tpi, pgm, and eno, encoding triose phosphate isomerase, phosphoglycerate mutase (PGM), and enolase, respectively, have been cloned and sequenced. These genes are the last three in a large putative operon coding for glycolytic enzymes; the operon includes pgk (coding for phosphoglycerate kinase) followed by tpi, pgm, and eno. The triose phosphate isomerase and enolase from B. subtilis are extremely similar to those from all other species, both eukaryotic and prokaryotic. However, B. subtilis PGM bears no resemblance to mammalian, fungal, or gram-negative bacterial PGMs, which are dependent on 2,3-diphosphoglycerate (DPG) for activity. Instead, B. subtilis PGM, which is DPG independent, is very similar to a DPG-independent PGM from a plant species but differs from the latter in the absolute requirement of B. subtilis PGM for Mn2+. The cloned pgm gene has been used to direct up to 25-fold overexpression of PGM in Escherichia coli; this should facilitate purification of large amounts of this novel Mn(2+)-dependent enzyme. Inactivation of pgm plus eno in B. subtilis resulted in extremely slow growth either on plates or in liquid, but growth of these mutants was enhanced by supplementation of media with malate. However, these mutants were asporogenous with or without malate supplementation.
Cognitive function and social abilities in patients with schizophrenia: Relationship with atypical antipsychotics

Abstract Although atypical antipsychotics have been associated with improvements in cognitive function in schizophrenia, the neurochemical basis for such effects is not well understood. Candidate neurotransmitter systems primarily involve dopamine and serotonin. The current study explored this issue by examining the cognitive abilities, social function and quality of life in patients with schizophrenia who were medicated with atypical antipsychotics. Comparisons were done for matched schizophrenia patients who were on antipsychotics with (i) an affinity for multiple receptors (olanzapine, clozapine, quetiapine) versus those that have preferential affinity for dopamine receptors (risperidone, amisulpride); and patients on medication with (ii) a high affinity for serotonin (5HT‐2A) receptors (risperidone, olanzapine, clozapine) versus those with a low (or no) affinity for 5HT‐2A receptors (quetiapine, amisulpride). No differences emerged between groups on any cognitive or social variable when the groups were compared for the dopaminergic properties of antipsychotic medication. By contrast, differences did emerge when patients were compared on the 5HT‐2A affinity of their antipsychotic medications. Patients on low 5HT‐2A‐affinity antipsychotics exhibited a better performance on a measure of selective attention and adjustment to living. These findings accord with the notion that serotonergic mechanisms are important determinants of both the cognitive and the social effects of the atypical antipsychotics.
The acid adaptive tolerance response in Campylobacter jejuni induces a global response, as suggested by proteomics and microarrays

Campylobacter jejuni CI 120 is a natural isolate obtained during poultry processing and has the ability to induce an acid tolerance response (ATR) to acid + aerobic conditions in early stationary phase. Other strains tested they did not induce an ATR or they induced it in exponential phase. Campylobacter spp. do not contain the genes that encode the global stationary phase stress response mechanism. Therefore, the aim of this study was to identify genes that are involved in the C. jejuni CI 120 early stationary phase ATR, as it seems to be expressing a novel mechanism of stress tolerance. Two‐dimensional gel electrophoresis was used to examine the expression profile of cytosolic proteins during the C. jejuni CI 120 adaptation to acid + aerobic stress and microarrays to determine the genes that participate in the ATR. The results indicate induction of a global response that activated a number of stress responses, including several genes encoding surface components and genes involved with iron uptake. The findings of this study provide new insights into stress tolerance of C. jejuni, contribute to a better knowledge of the physiology of this bacterium and highlight the diversity among different strains.
Fuzzy Model-Based Control : A Practical Approach

This paper addresses the main steps in model-based control: the identification of the model and the design of the controller. A series of recent research results is aggregated to present a complete approach. A fuzzy model of the system is identified from sampled data using supervised fuzzy clustering for rule extraction. This model is applied in model predictive control (MPC) of the process. The non-convex optimization problem introduced by a nonlinear plant model is solved by discretizing the control space and apply discrete search techniques. The trade-off between computational time and performance that follows from the discretization is addressed by using fuzzy rule-based optimization to adapt the discrete control actions. The global fuzzy model-based control approach is applied to pressure control of a fermentation tank. Key-Words:fuzzy model-based control, fuzzy modeling, discrete model predictive control, discrete optimization.
Synthesis of application-specific highly-efficient multi-mode systems for low-power applications

We present a novel design methodology for synthesizing multiple configurations (or modes) into a single programmable system. Many DSP and multimedia applications require reconfigurability of a system along with efficiency in terms of power performance and area. FPGAs provide a reconfigurable platform, however, they are slower in speed with significantly higher power consumption than achievable by a customized ASIC. In this work, we have developed techniques to realize an efficient reconfigurable system for a set of user-specified configurations. A data flow graph transformation method coupled with efficient scheduling and allocation are used to automatically synthesize the system from its behavioral level specifications. Experimental results on several applications demonstrate that we can achieve about 60/spl times/ power reduction on average with about 4/spl times/ improvement in performance over corresponding FPGA implementations.
Investigating effects of visual and tactile feedback on spatial coordination in collaborative handheld systems

Mobile and handheld devices have become platforms to support remote collaboration. But, their small form-factor may impact the effectiveness of the visual feedback channel often used to help users maintain an awareness of their partner's activities during synchronous collaborative tasks. We investigated how visual and tactile feedback affects collaboration on mobile devices, with emphasis on spatial coordination in a shared workspace. From two user studies, our results highlight different benefits of each feedback channel in collaborative handheld systems. Visual feedback can provide precise spatial information for collaborators, but degrades collaboration when the feedback is occluded, and sometimes can distract the user's attention. Spatial tactile feedback can reduce the overload of information in visual space and gently guides the user's attention to an area of interest. Our results also show that visual and tactile feedback can complement each other, and systems using both feedback channels can support better spatial coordination than systems using only one form of feedback.
Dissemination of a Highly Virulent Pathogen: Tracking The Early Events That Define Infection

The series of events that occurs immediately after pathogen entrance into the body is largely speculative. Key aspects of these events are pathogen dissemination and pathogen interactions with the immune response as the invader moves into deeper tissues. We sought to define major events that occur early during infection of a highly virulent pathogen. To this end, we tracked early dissemination of Yersinia pestis, a highly pathogenic bacterium that causes bubonic plague in mammals. Specifically, we addressed two fundamental questions: (1) do the bacteria encounter barriers in disseminating to draining lymph nodes (LN), and (2) what mechanism does this nonmotile bacterium use to reach the LN compartment, as the prevailing model predicts trafficking in association with host cells. Infection was followed through microscopy imaging in addition to assessing bacterial population dynamics during dissemination from the skin. We found and characterized an unexpected bottleneck that severely restricts bacterial dissemination to LNs. The bacteria that do not pass through this bottleneck are confined to the skin, where large numbers of neutrophils arrive and efficiently control bacterial proliferation. Notably, bottleneck formation is route dependent, as it is abrogated after subcutaneous inoculation. Using a combination of approaches, including microscopy imaging, we tested the prevailing model of bacterial dissemination from the skin into LNs and found no evidence of involvement of migrating phagocytes in dissemination. Thus, early stages of infection are defined by a bottleneck that restricts bacterial dissemination and by neutrophil-dependent control of bacterial proliferation in the skin. Furthermore, and as opposed to current models, our data indicate an intracellular stage is not required by Y. pestis to disseminate from the skin to draining LNs. Because our findings address events that occur during early encounters of pathogen with the immune response, this work can inform efforts to prevent or control infection.
OMEGA, a Randomized, Placebo-Controlled Trial to Test the Effect of Highly Purified Omega-3 Fatty Acids on Top of Modern Guideline-Adjusted Therapy After Myocardial Infarction

Background— There is no randomized, double-blind trial testing the prognostic effect of highly purified omega-3 fatty acids in addition to current guideline-adjusted treatment of acute myocardial infarction. Methods and Results— OMEGA is a randomized, placebo-controlled, double-blind, multicenter trial testing the effects of omega-3-acid ethyl esters-90 (1 g/d for 1 year) on the rate of sudden cardiac death in survivors of acute myocardial infarction, if given in addition to current guideline-adjusted treatment. Secondary end points were total mortality and nonfatal clinical events. Patients (n=3851; female, 25.6%; mean age, 64.0 years) were randomized in 104 German centers 3 to 14 days after acute myocardial infarction from October 2003 until June 2007. Acute coronary angiography was performed in 93.8% and acute percutaneous coronary intervention in 77.8% of all patients. During a follow-up of 365 days, the event rates were (omega and control groups) as follows: sudden cardiac death, 1.5% and 1.5% (P=0.84); total mortality, 4.6% and 3.7% (P=0.18); major adverse cerebrovascular and cardiovascular events, 10.4% and 8.8% (P=0.1); and revascularization in survivors, 27.6% and 29.1% (P=0.34). Conclusions— Guideline-adjusted treatment of acute myocardial infarction results in a low rate of sudden cardiac death and other clinical events within 1 year of follow-up, which could not be shown to be further reduced by the application of omega-3 fatty acids. Clinical Trial Registration— URL: http://www.clinicaltrials. gov. Unique identifier: NCT00251134.
Road Traffic Deaths and Injuries Are Under-Reported in Ethiopia: A Capture-Recapture Method

In low and middle income countries road traffic injuries are commonly under-reported. This problem is significantly higher among those less severely injured road users. The objective of this study was to determine the incidence and the level of ascertainment of road traffic injuries and deaths by traffic police and hospital registry. In this study two-sample capture-recapture method was applied using data from traffic police and hospital injury surveillance, through June 2012 to May 2013. The study was conducted on one of the busiest highways in Ethiopia, the Addis Ababa – Hawassa highway. Primary data were collected by accident investigators and hospital emergency nurses using a structured checklist. Four matching variables; name of the victim, sex, place and time of the accidents was used to get the matched cases. During the study period the police independently reported 224 deaths and 446 injuries/billion vehicle kilometer while hospitals reported 123 deaths and 1,046 injuries/billion vehicle kilometer. Both sources in common captured 73 deaths and 248 injuries/billion vehicle kilometer. Taking the two data sources into consideration, the capture-recapture model estimated the incidence of deaths and injuries ranged 368–390 and 1,869–1,895 per billion vehicle kilometer, respectively. The police source captured 57.4%–60.9% of deaths and 23.5%–23.9% of injuries while the hospital sources captured 31.5%–33.4% of deaths and 55.2%–56% of injuries. Deaths and injuries among females, younger age victims, cyclists/motorcyclists and pedestrians were under-reported by traffic police. In conclusion neither of the two sources independently provided accurate coverage of road traffic incident related deaths and injuries. Strengthening both systems is necessary to obtain accurate information on road accidents and human causalities.
Energy-Aware Scheduling on Multiprocessor Platforms with Devices

In this paper, we address the problem of energy-aware task scheduling on DVFS-enabled multiprocessors with DPM-enabled device(s). Given a set of frame-based tasks, we aim to derive a scheduling where the device occupation constraint is respected, all of the tasks meet the shared deadline, and the overall system energy consumption, including energy consumed on both processors and devices, is minimized. For the problem when preemption and migration are allowed, after solving the formulated optimization problem, we regard the tasks that require the same device as a single preemptive task. An Execution Time Filling (ETF) process can be applied to derive a scheduling which adopts the optimal frequency setting, then, we propose Algorithm ETFR, which achieves the optimal system energy consumption, and also Reduces the total number of preemptions and migrations. For the problem when tasks are non-preemptive, we regard the tasks that require the same device as a single non-preemptive task. To assign tasks to processors, we adopt the Worst Fit Decreasing (WFD) strategy using tasks' optimal execution times. After task assignment, we readjust the execution frequency of tasks on each processor, such that the system energy consumption of tasks on each processor is minimized. Various analysis, simulations, and experiments verify the strength of our proposed approaches for the two problems.
Special text processing based external descriptor rule

In this paper, a special text processing method is presented, which integrates external descriptor rule and model matching. The letter-to-sound rules for a given kind of special mark can be described by some describable features which can be extracted from this kind of special mark, and then a corresponding model can be built and then the model parameter can be stored into a external form. Since the features can be extracted and described conveniently, a new model can be built easily for improving the ability to analyze special text.