Miracle-dz/UniFAR-FTUs huggingface dataset:
On unifying control barrier and Lyapunov functions using QP and Sontag's formula with an application to tumor dynamics

A common tool in system theory for formulating control laws that achieve local asymptotic stability are Control Lyapunov functions (CLFs), while Control Barrier functions (CBFs) are typically employed to enforce safety constraints. Combining these two types of functions is of interest, because it leads to stabilizing controllers with safety guarantees. A common approach to merge CLFs and CBFs is to solve an optimization problem where both CLF and CBF inequalities are imposed as constraints. In this paper, we show via an example from the literature that this approach can lead to undesirable behavior (i.e., slow convergence and oscillating inputs). Then, we propose a novel cost function that penalizes the deviation from Sontag's formula by using a state-dependent weighting matrix. We show that by minimizing the developed cost function subject to a CBF constraint, local asymptotic stability is obtained with an explicit domain of attraction, without using a CLF constraint. To deal with vanishing properties of the weight matrix as the state approaches the equilibrium, we introduce a hybrid continuous control law that recovers Sontag's formula locally. The effectiveness of the developed hybrid stabilizing control law based on CLFs and CBFs is illustrated in stabilization of a 3D tumor model, subject to physiological constraints (i.e., all states must be positive), which yields useful insights into optimal cancer treatment design.
Reranking Passages with Coarse-to-Fine Neural Retriever Enhanced by List-Context Information

Passage reranking is a critical task in various applications, particularly when dealing with large volumes of documents. Existing neural architectures have limitations in retrieving the most relevant passage for a given question because the semantics of the segmented passages are often incomplete, and they typically match the question to each passage individually, rarely considering contextual information from other passages that could provide comparative and reference information. This paper presents a list-context attention mechanism to augment the passage representation by incorporating the list-context information from other candidates. The proposed coarse-to-fine (C2F) neural retriever addresses the out-of-memory limitation of the passage attention mechanism by dividing the list-context modeling process into two sub-processes with a cache policy learning algorithm, enabling the efficient encoding of context information from a large number of candidate answers. This method can be generally used to encode context information from any number of candidate answers in one pass. Different from most multi-stage information retrieval architectures, this model integrates the coarse and fine rankers into the joint optimization process, allowing for feedback between the two layers to update the model simultaneously. Experiments demonstrate the effectiveness of the proposed approach.
Clinical, demographic and histopathological prognostic factors for urothelial carcinoma of the bladder

Introduction Our aim is to evaluate the influence of clinical and histopathological parameters, including age, gender, tumor stage, grade, tumor differentiation, necrosis, lymphovascular/perineural invasion (LVI/PNI) and concomitant carcinoma in situ (CIS), on outcomes of patients with urothelial carcinoma of the bladder (UCB). Material and methods A total of 84 patients who underwent radical cystectomy (RC) (n = 11) and radical cystoprostatectomy (n = 73) for muscle-invasive bladder cancer at our hospital between 2007-2013, were included in the study. Results The mean age of patients at diagnosis was 66.1, of whom 75 were males and 9 were females. Of the 84 patients, 38 were ≤65 years and 46 were >65 years. Mean tumor diameter was 3.66 cm. There were 38 cases which showed divergent differentiations. Concomitant CIS was observed in 30 tumors, 41 cases showed tumor necrosis, 44 PNI and 61 LVI. The rate of overall survival (OS) in patients aged ≤65 years was statistically significantly higher than in those aged >65 years. A negative statistical relationship was found between OS with lymph node metastasis (LNM) and tumor differentiation. On the other hand, necrosis did not remain significant on multivariate analysis. No statistically significant relationship was found between smoking, tumor stage, PNI, LVI and concomitant CIS and OS. Conclusions In this study, advanced age, LNM, tumor differentiation were found to be independent prognostic risk factors associated with OS after RC. These additional factors, which may explain the different clinical course in patients with similar tumor stage and lymph node status, should be taken into consideration in treatment planning.
Constructing hybrid software process simulation models

Software process simulation (SPS) has become an active research area for managing and improving software development processes since its introduction in the last two decades. Hybrid simulation, the combination of simulation paradigms to address a problem, is becoming more popular as the problems we are presented with become more complex. However, integrating multiple simulation paradigms faces the issues of compatibility, interoperatability and synchronization when executing simulation. The objective of this research is to present the state-of-the-art of this research area, the hybrid mechanism when integrating paradigms, and more importantly provide practical support for the effective adoption of hybrid simulation in SPS context. Based on an extended systematic literature review, this paper presents the preliminary results by answering the research questions. Depending upon the way these simulation paradigms represent different aspects and levels of software process and the context in which they can be modeled by SPS, two hybrid mechanisms: Hierarchical Mechanism and Interlinked Mechanism, have been frequently employed. The detailed discussions of integration strategies and recommendations when applying hybrid simulation may offer reference value to the SPS community.
Intravenous iron: From anathema to standard of care

A growing body of literature supports the use of intravenous iron as a compliment to erythropoiesis stimulatory therapy and in a significant number of disease states where iron is necessary and oral iron is ineffective or not tolerated. The differences in efficacy, safety, and clinical nature of serious adverse events that occur with the various iron preparations are poorly understood. Misinterpretation of adverse events leads to underutilization of this important treatment modality. Understanding the history of the development and use of intravenous iron is crucial to appreciate its importance in the management of anemias of dialysis, cancer, and cancer chemotherapy and properly assess side effects and toxicity. The benefits seen with intravenous iron therapy are independent of the pretreatment levels of serum ferritin, iron, total iron binding capacity, and percent transferrin saturation. Intravenous iron has been shown to overcome hepcidin induced iron restricted erythropoiesis in iron‐replete patients. Available clinical and experimental data suggest that increased utilization of intravenous iron should be considered. Am. J. Hematol. , 2008. © 2008 Wiley‐Liss, Inc.
Development a Model for Analyzing the Walking Dynamic Simulation of Wearable Walking Assistant Robot

In this study, basic research to obtain biomechanical parameters for optimized design of wearable walking assistant robot was presented and discussed in the condition of its application to the dynamic analysis of gait. Numerous studies are being conducted in order to develop intelligent walking assist devices. However, the reliability, effectiveness and durability of such intelligent walking assist devices are difficult to measure, and many obstacles including the cost for developing the system and limited clinical trials hinder in the development of an effective system through optimal design. This study attempted to overcome such difficulties by employing 3 dimensional motion analysis system and computer simulation in analyzing joint load characteristics applied to joints when walking up the stairs wearing PGO. In this research, a human body model was developed by utilizing a normal adult’s joint load characteristics of different positional changes, which is believed to be applicable to a study on joint load characteristics with PGO according to various positional changes. The tested human body model parameter, which was obtained by wearing PGO and walking up the stairs, was as follows. The maximum torques of knee joint and hip joint on the sagittal plane while walking up the stairs were 1.7m/kg and 0.7Nm/kg respectively, which were turned out to be greater than the lower limb joint load a normal adult walked up the stairs wearing PGO.
Efficient Regular Perovskite Solar Cells Based on Pristine [70]Fullerene as Electron-Selective Contact.

[70]Fullerene is presented as an efficient alternative electron-selective contact (ESC) for regular-architecture perovskite solar cells (PSCs). A smart and simple, well-described solution processing protocol for the preparation of [70]- and [60]fullerene-based solar cells, namely the fullerene saturation approach (FSA), allowed us to obtain similar power conversion efficiencies for both fullerene materials (i.e., 10.4 and 11.4 % for [70]- and [60]fullerene-based devices, respectively). Importantly, despite the low electron mobility and significant visible-light absorption of [70]fullerene, the presented protocol allows the employment of [70]fullerene as an efficient ESC. The [70]fullerene film thickness and its solubility in the perovskite processing solutions are crucial parameters, which can be controlled by the use of this simple solution processing protocol. The damage to the [70]fullerene film through dissolution during the perovskite deposition is avoided through the saturation of the perovskite processing solution with [70]fullerene. Additionally, this fullerene-saturation strategy improves the performance of the perovskite film significantly and enhances the power conversion efficiency of solar cells based on different ESCs (i.e., [60]fullerene, [70]fullerene, and TiO2 ). Therefore, this universal solution processing protocol widens the opportunities for the further development of PSCs.
Intra-aortic balloon occlusion to salvage patients with life-threatening hemorrhagic shocks from pelvic fractures.

OBJECTIVE The purpose of this study was to describe a blinded intra-aortic balloon occlusion (IABO) procedure in pelvic fractures (PF) for patients with critically uncontrollable hemorrhagic shock (CUHS). METHODS Of 2,064 patients treated for PF, 13 underwent IABO during initial resuscitation to control massive pelvic bleeding leading to CUHS. Our IABO procedure consists of internal aortic occlusion without fluoroscopy, using a latex balloon inflated in the infrarenal aorta. Retrospectively collected data included demographics, fracture classification, additional injuries, blood transfusions, surgical interventions, angiographic procedure, physiologic parameters, and survival. RESULTS All balloons were successfully placed, and a significant increase in systolic blood pressure (70 mm Hg, p = 0.001) was observed immediately after IABO. Twelve of 13 patients became transferrable. Angiography performed after IABO was positive for arterial injury in 92% of patients, and 9 patients benefitted from arterial embolization. Survival rate was 46% (6 of 13) and was inversely related to the length of inflation (p = 0.026) and the mean Injury Severity Score (p = 0.011). CONCLUSION This IABO procedure can be life saving in the management of patients with CUHS from PF, permitting transport to angiography. However, the decision for such treatment must be as quickly as possible after trauma to reduce the time of occlusion.
Sub-Perfect Game: Profitable Biases of NBA Referees

This paper empirically investigates three hypotheses regarding biases of National Basketball Association referees. Identification of basketball referee bias is typically difficult as changes in observed statistics may be caused by either changes in referee bias or player behavior. We identify bias by exploiting the fact that referees have varying degrees of discretion over different types of a particular statistic-turnovers. This allows us to conduct a treatment and control-style analysis, using the less discretionary turnovers as the player behavior control. The results provide evidence that referees favor home teams, teams losing during games, and teams losing in playoff series. All three biases are likely to increase consumer demand.
Wanda: a database of duplicated fish genes

Comparative genomics has shown that ray-finned fish (Actinopterygii) contain more copies of many genes than other vertebrates. A large number of these additional genes appear to have been produced during a genome duplication event that occurred early during the evolution of Actinopterygii (i.e. before the teleost radiation). In addition to this ancient genome duplication event, many lineages within Actinopterygii have experienced more recent genome duplications. Here we introduce a curated database named Wanda that lists groups of orthologous genes with one copy from man, mouse and chicken, one or two from tetraploid Xenopus and two or more ancient copies (i.e. paralogs) from ray-finned fish. The database also contains the sequence alignments and phylogenetic trees that were necessary for determining the correct orthologous and paralogous relationships among genes. Where available, map positions and functional data are also reported. The Wanda database should be of particular use to evolutionary and developmental biologists who are interested in the evolutionary and functional divergence of genes after duplication. Wanda is available at http://www.evolutionsbiologie. uni-konstanz.de/Wanda/.
Optimal user power manipulation aided cooperative sensing schemes for cognitive radios

In recent years, cooperative spectrum sensing (CSS) for cognitive radio networks (CRN) have been widely investigated in various research aspects. With an aim to develop easy-to-implement CSS schemes, this paper proposes two optimal strategies to manipulate the transmit powers of the cooperative secondary users (SU) in the CSS intervals. When the joint channel statistics (CS) of the sensing and reporting channels are perfectly known at the fusion center (FC), we first derive a CS aided optimal user power manipulation (CSA-OUPM) scheme in closed-form; when the CS are entirely unknown, a blind user power control method is developed, namely the principal eigenvector aided OUPM (PEV-OUPM). Theoretical analysis and computer simulations verify that the proposed OUPM schemes are capable of potentially allocating more power to the cooperative SUs with better channel condition and hence achieve significantly ameliorated performance.
Hiding in Plain Sight: Interplay between Staphylococcal Biofilms and Host Immunity

Staphylococcus aureus and Staphylococcus epidermidis are notable for their propensity to form biofilms on implanted medical devices. Staphylococcal biofilm infections are typified by their recalcitrance to antibiotics and ability to circumvent host immune-mediated clearance, resulting in the establishment of chronic infections that are often recurrent in nature. Indeed, the immunomodulatory lifestyle of biofilms seemingly shapes the host immune response to ensure biofilm engraftment and persistence in an immune competent host. Here, we provide a brief review of the mechanisms whereby S. aureus and S. epidermidis biofilms manipulate host–pathogen interactions and discuss the concept of microenvironment maintenance in infectious outcomes, as well as speculate how these findings pertain to the challenges of staphylococcal vaccine development.
Protestant and Online: The Case of Aiyan*

Abstract This article presents Aiyan, an electronic house church publication, as a case study of a resistance community using up-to-date technology in the dual context of China's modernization and government repression. Based on detailed content analysis supported by results from fieldwork, the article introduces Aiyan's background as an underground publication, its online existence, its visual character, its content and its aims. It then analyses Aiyan's attempts at identity formation within the complex realities of religious activity in China, and finally identifies five main areas of political engagement within Aiyan: freedom of religious belief and legalization of status; rights awareness and rights education; defiance against the regime; rural–urban co-operation; and engagement of liberal intellectuals. The article concludes with an evaluation of the possible influence this sector of the house church community may have on China's political transformation.
Serotonin transporter gene, childhood emotional abuse and cognitive vulnerability to depression

Meta‐analyses evaluating the association between the serotonin transporter polymorphism (5‐HTTLPR) with neuroticism and depression diagnosis as phenotypes have been inconclusive. We examined a gene–environment interaction on a cognitive vulnerability marker of depression, cognitive reactivity (CR) to sad mood. A total of 250 university students of European ancestry were genotyped for the 5‐HTTLPR, including SNP rs25531, a polymorphism of the long allele. Association analysis was performed for neuroticism, CR and depression diagnosis (using a self‐report measure). As an environmental pathogen, self‐reported history of childhood emotional abuse was measured because of its strong relationship with depression. Participants with the homozygous low expressing genotype had high CR if they had experienced childhood emotional maltreatment but low CR if they did not have such experience. This interaction was strongest on the Rumination subscale of the CR measure. The interaction was not significant with neuroticism or depression diagnosis as outcome measures. Our results show that 5‐HTTLPR is related to cognitive vulnerability to depression. Our findings provide evidence for a differential susceptibility genotype rather than a vulnerability genotype, possibly because of the relatively low levels of abuse in our sample. The selection of phenotype and environmental contributor is pivotal in investigating gene–environment interactions in psychiatric disorders.
Prevalence of subclinical infection and transmission of severe acute respiratory syndrome (SARS) in a residential care home for the elderly.

OBJECTIVE To ascertain the prevalence of subclinical severe acute respiratory syndrome-coronavirus (SARS-CoV) infection and study the transmission of SARS-CoV in a local outbreak at a residential care home for the elderly. DESIGN Cross-sectional study. SETTING A residential care home for the elderly in Hong Kong with a local outbreak of SARS. PARTICIPANTS Residents and staff in the residential care home who had contact with three patients with SARS (residents A and B, and staff C). MAIN OUTCOME MEASURES Blood samples were tested for total antibodies to SARS-CoV by immunofluorescence antibody test. The transmission of SARS was elucidated based on information from standardised questionnaires, and records of investigation and surveillance by the Department of Health. RESULTS Among the 90 eligible residents, three died, one moved out, and 19 refused to participate. Of the 32 eligible staff, six refused to participate. None of the remaining 93 participants tested positive for antibody to SARS-CoV. Based on the chronological order, resident A might have transmitted infection to resident B and staff C. Sitting close to the bathroom doorway while resident A took a shower was the only contact of resident B with resident A. The only opportunity for staff C to have contact with body fluids/excreta of resident A was in the handling of rubbish from the resident's room. CONCLUSION Subclinical SARS-CoV infection was rare in a residential care home for the elderly with an outbreak of SARS. Nonetheless the close working and living conditions for staff and residents in such a home may facilitate transmission of SARS despite vigilant precautionary measures.
Fibromyalgia Syndrome and Chronotype

Sleep has strong links to the symptomology of fibromyalgia syndrome (FMS), a diffuse musculoskeletal pain disorder. Information about the involvement of the circadian clock is, however, sparse. In this study, 1548 individuals with FMS completed an online survey containing questions on demographics, stimulant consumption, sleep quality, well-being and subjective pain, chronotype (assessed by the Munich ChronoType Questionnaire, MCTQ), and FMS impact. Chronotype (expressed as the mid-sleep-point on free days, corrected for sleep deficit on workdays, MSFsc) significantly correlated with stress-ratings, so-called “memory failures in everyday life,” fatigue, FMS impact, and depression but not with anxiety. When chronotypes were categorized into 3 groups (early, intermediate, late), significant group differences were found for sum scores of perceived stress, memory failures in everyday life, fatigue, FMS impact, and depression but not anxiety, with late chronotypes being more affected than early chronotypes. Sleepiness ratings were highest in early chronotypes. Challenges of sleep quality and subjective pain were significantly increased in both early and late chronotypes. The results show that according to their reports, late chronotypes are more affected by fibromyalgia.
Drug-associated dermatomyositis following ipilimumab therapy: a novel immune-mediated adverse event associated with cytotoxic T-lymphocyte antigen 4 blockade.

IMPORTANCE Ipilimumab, a human monoclonal antibody targeted against cytotoxic T-lymphocyte antigen 4, has shown promise in the treatment of metastatic melanoma. However, given its mechanism of action, immune-related adverse effects have been reported with this therapy. Despite increasing reports of immune-related adverse effects related to ipilimumab therapy, dermatomyositis associated with this agent has not previously been reported. OBSERVATIONS We describe a woman undergoing treatment with ipilimumab for metastatic melanoma who developed classic cutaneous findings of dermatomyositis along with proximal muscle weakness and elevated muscle enzymes. CONCLUSIONS AND RELEVANCE This case adds to the expanding literature regarding immune-related adverse events associated with ipilimumab. To our knowledge, drug-induced dermatomyositis from ipilimumab has not previously been reported. Physicians should be aware of these potential immune-related adverse events and consider drug-associated dermatomyositis in the differential diagnosis in patients receiving ipilimumab who present with a cutaneous eruption or muscle weakness.