Miracle-dz/UniFAR-FTUs huggingface dataset:
Tage4/Nectin-like Molecule-5 Heterophilically trans-Interacts with Cell Adhesion Molecule Nectin-3 and Enhances Cell Migration*

Malignant transformation of cells causes disruption of cell-cell adhesion, enhancement of cell motility, and invasion into surrounding tissues. Nectins have both homophilic and heterophilic cell-cell adhesion activities and organize adherens junctions in cooperation with cadherins. We examined here whether Tage4, which was originally identified to be a gene overexpressed in colon carcinoma and has a domain structure similar to those of nectins, is involved in cell adhesion and/or migration. Tage4 heterophilically trans-interacted with nectin-3, but not homophilically with Tage4. Expression of Tage4 was markedly elevated in NIH3T3 cells transformed by an oncogenic Ki-Ras (V12Ras-NIH3T3 cells) as compared with that of wild-type NIH3T3 cells. trans-Interaction of Tage4 with nectin-3 enhanced motility of V12Ras-NIH3T3 cells. Tage4 did not bind afadin, a nectin- and actin filament-binding protein that connects nectins to the actin cytoskeleton and cadherins through catenins. Thus, Tage4 heterophilically trans-interacts with nectin-3 and regulates cell migration. Tage4 is tentatively re-named here nectin-like molecule-5 (necl-5) on the basis of its function and domain structure similar to those of nectins.
A Compact Via-Hole-Free Hairpin-Comb Bandpass Filter With 50-dB Stopband Suppression Up to Quadruple Passband Frequency

A compact microstrip hairpin-comb bandpass filter with strong spurious-band suppression up to a quadruple of passband central frequency is presented. The open-circuited stepped-impedance resonators are folded in a U-shape and aligned in the same orientation such that the filter has advantages of smaller filter length and free of via-hole grounds. The input and output tapped-transformer feeding scheme is employed for impedance match and for higher stopband suppression. A demonstrated 2.45-GHz hairpin-comb bandpass filter achieves measurement results of 50-dB stopband rejection up to 10 GHz with a maximum of 80 dB suppression from 6.5 to 7.5 GHz.
Economic burden of rheumatoid arthritis: a systematic review.

OBJECTIVE To summarize the state of knowledge with regard to the economic impact of rheumatoid arthritis (RA) and to highlight any weaknesses in the work conducted to date, so as to inform future RA cost-of-illness studies. METHODS Four computerized literature databases were searched to identify all the literature relevant to this review. Seven elements indicating a quality cost-of-illness study were established and used to appraise the literature identified critically. Where possible, costs reported by the different studies were converted to 1996 US dollars using the consumer price index for medical care. RESULTS Total average medical costs were reported to range from US$5720 (UK pound3575) to US$5822 (UK pound3638). Medication constituted between 8 and 24% of total medical costs, physician visits between 8 and 21%, and in-patient stays between 17 and 88%. The average number of days absent from work due to a person's RA was reported to range from 2.7 to 30 days/year. CONCLUSION The economic impact of RA in terms of cost was reported to be substantial by all studies reviewed. However, methodological problems meant that discrepancies in the average (per person) annual cost of RA existed across studies.
Method Based on GSCPN for Network Vulnerability Analysis

With the development of network security research, network attack modeling and analysis techniques have been paid more and more attention. A generalized stochastic colored Petri Net (GSCPN) Model is proposed. To each attack, a GSCPN model is constructed to describe the relation of components graphically. Algorithm to construct a composite attack and method for network vulnerability analysis are delivered also. The exploitation cost of vulnerabilities is estimated. The method is relatively simple, which is different from traditional method. The network example further validates the proposed method for network vulnerability analysis.
Serotonin Agonist Quipazine Induces Photic-Like Phase Shifts of the Circadian Activity Rhythm and c-Fos Expression in the Rat Suprachiasmatic Nucleus

Nonphotic stimuli can reset and entrain circadian activity rhythms in hamsters and mice, and serotonin is thought to be involved in the phase-resetting effects of these stimuli. In the present study, the authors examined the effect of the serotonin agonist quipazine on circadian activity rhythms in three inbred strains of rats (ACI, BH, and LEW). Furthermore, they investigated the effect of quipazine on the expression of c-Fos in the mammalian circadian pacemaker, the suprachiasmatic nucleus (SCN). Quipazine reduced the amount of running wheel activity for 3 h after treatment, however, no long-term changes in τ and in the activity level were observed. More important, quipazine induced significant phase advances of the activity rhythm and c-Fos production in the SCN at the end of the subjective night (Circadian Time [CT] 22), whereas neither phase shifts nor c-Fos induction were observed during the subjective day. Quipazine injections also resulted in moderate phase delays at the beginning of the subjective night (CT 14). A similar phase-response characteristic typically can be observed for photic stimuli. By contrast, nonphotic stimuli normally produce phase advances during the subjective day. The present results suggest species differences between the hamster and the rat with respect to the serotonergic action on circadian timekeeping and indicate that serotonergic pathways play a role in the transmission of photic information to the SCN of rats.
The Burden of Human African Trypanosomiasis

Human African trypanosomiasis (HAT, or sleeping sickness) is a protozoan parasitic infection caused by Trypanosoma brucei rhodesiense or Trypanosoma brucei gambiense. These are neglected tropical diseases, and T.b. rhodesiense HAT is a zoonosis. We review current knowledge on the burden of HAT in sub-Saharan Africa, with an emphasis on the disability-adjusted life year (DALY), data sources, and methodological issues relating to the use of this metric for assessing the burden of this disease. We highlight areas where data are lacking to properly quantify the impact of these diseases, mainly relating to quantifying under-reporting and disability associated with infection, and challenge the HAT research community to tackle the neglect in data gathering to enable better evidence-based assessments of burden using DALYs or other appropriate measures.
Nurses and stress: recognizing causes and seeking solutions.

AIMS To identify, from the perspectives of nurses, occupational stressors and ways in which they may be reduced. BACKGROUND Nurses commonly experience high levels of occupational stress, with negative consequences for their physical and psychological health, health-care organisations and community. There is minimal research on reducing occupational stress. METHOD Six focus groups were conducted with 38 registered nurses using a qualitative exploratory approach. Participants were asked to identify sources of occupational stress and possible workplace initiatives to reduce stress. FINDINGS Sources of occupational stress were: high workloads, unavailability of doctors, unsupportive management, human resource issues, interpersonal issues, patients' relatives, shift work, car parking, handover procedures, no common area for nurses, not progressing at work and patient mental health. Suggestions for reduction included: workload modification, non-ward-based initiatives, changing shift hours, forwarding suggestions for change, music, special events, organisational development, ensuring nurses get breaks, massage therapists, acknowledgement from management and leadership within wards. CONCLUSION The findings highlight the need to understand local perspectives and the importance of involving nurses in identifying initiatives to reduce occupational stress. IMPLICATIONS FOR NURSING MANAGEMENT Health-care environments can be enhanced through local understanding of the occupational stressors and productively engaging nurses in developing stress reduction initiatives. Nurse managers must facilitate such processes.
Disruption of the C-terminal helix by single amino acid deletion is directly responsible for impaired cholesterol efflux ability of apolipoprotein A-I Nichinan

Apolipoprotein A-I (apoA-I) Nichinan, a naturally occurring variant with ΔE235 in the C terminus, is associated with low plasma HDL levels. Here, we investigated the tertiary structure, lipid-binding properties, and ability to induce cellular cholesterol efflux of apoA-I Nichinan and its C-terminal peptide. Thermal and chemical denaturation experiments demonstrated that the ΔE235 mutation decreased the protein stability compared with wild type (WT). ApoA-I Nichinan exhibited capabilities to bind to or solubilize lipid vesicles that are intermediate to that of WT and a L230P/L233P/Y236P variant in which the C-terminal α-helix folding is completely disrupted and forms relatively larger and unstable discoidal complexes, indicating that perturbation of the C-terminal α-helical structure by the ΔE235 mutation leads to reduced lipid binding. Supporting this, apoA-I 209-241/ΔE235 peptide showed significantly decreased ability to form α-helix both in the lipid-free and lipid-bound states, and reduced efficiency to solubilize vesicles. In addition, both apoA-I Nichinan and its C-terminal peptide exhibited reduced activity in ABCA1-mediated cellular cholesterol efflux. Thus, the disruption of the ability of the C-terminal region to form α-helix caused by the E235 deletion appears to be the important determinant of impaired lipid binding and cholesterol efflux ability and, consequently, the low plasma HDL levels of apoA-I Nichinan probands.
Expression of receptors for human angiogenin in vascular smooth muscle cells.

Human angiogenin is a plasma protein with angiogenic and ribonucleolytic activities. Angiogenin inhibited both DNA replication and proliferation of aortic smooth muscle cells. Binding of 125I-angiogenin to bovine aortic smooth muscle cells at 4 degrees C was specific, saturable, reversible and involved two families of interactions. High-affinity binding sites with an apparent dissociation constant of 0.2 nm bound 1 x 104 molecules per cell grown at a density of 3 x 104.cm-2. Low-affinity binding sites with an apparent dissociation constant of 0.1 micrometer bound 4 x 106 molecules.cell-1. High-affinity binding sites decreased as cell density increased and were not detected at confluence. 125I-angiogenin bound specifically to cells routinely grown in serum-free conditions, indicating that the angiogenin-binding components were cell-derived. Affinity labelling of sparse bovine smooth muscle cells yielded seven major specific complexes of 45, 52, 70, 87, 98, 210 and 250-260 kDa. The same pattern was obtained with human cells. Potential modulators of angiogenesis such as protamine, heparin and the placental ribonuclease inhibitor competed for angiogenin binding to the cells. Together these data suggest that cultured bovine and human aortic smooth muscle cells express specific receptors for human angiogenin.
Optimal Energy-Efficient Relay Deployment for Two-Way Relay System with Non-Ideal Power Amplifier

Realistic power amplifier (PA) model plays a very important role in the energy efficiency analysis for relay system, since it takes up to 70% of the total power consumption. In this paper, we aim to investigate the impact of non-ideal PA on the optimal relay deployment for two-way relay system using amplify forward or decode forward protocol in comparison with that of ideal PA. In the two-way relay system, physical-layer network coding (PNC) is used to assist the relay communication. Taking both the realistic non-ideal PA and ideal PA into consideration, the closed-form expressions for the optimal energy-efficient relay deployment are derived. Relative numerical simulation results show that the impact of non-ideal PA on the optimal relay deployment is that it requires the relay node to be deployed nearer to base station (BS) than that with the ideal PA. Furthermore, the energy efficiency of the two-way relay system with non-ideal PA could be largely improved by applying the optimal relay deployment.
Is there any alternative to traditional food frequency questionnaire for evaluating habitual dietary intake?

INTRODUCTION Dietary assessment methods are an important instrument for nutrition research. Food frequency questionnaires (FFQs) have been the most frequently used dietary assessment tool in epidemiological and intervention studies. There is a great necessity for new methods of determination of habitual dietary intake that overcome the limitations of these traditional methods. OBJECTIVES The objectives of the present study were to develop a new method, based on an application for mobile phones called e-EPIDEMIOLOGY, designed to record individual consumption data about a short series of foods/drinks, and to compare data collected using this tool with those obtained from a previously validated short paper FFQ. METHODS University students over 18 years recorded the consumption of certain foods/drinks using e-EPIDEMIOLOGY during 28 consecutive days and then filled out a short paper FFQ at the end of the study period. To evaluate the agreement between both methods, Spearman's correlation coefficient, cross-classification analysis and a weighted kappa statistic were used. RESULTS One hundred and nineteen participants completed the study (71.4% female and 28.6% male). The mean Spearman's correlation coefficients for food/drink group intake between the two methods was 0.73. The mean percentage of participants cross-classified into categories of "exact agreement + adjacent" was 91.6%. The average weighted kappa statistic was 0.60. CONCLUSIONS The results indicate that e-EPIDEMIOLOGY has good agreement with the previously validated FFQ short paper. However, it was noted that further testing of e-EPIDEMIOLOGY is required to establish its wider utility.
Equality-Based Comparison: How to Justify Democratic Institutions in the Real World

Political scientists regularly justify particular democratic institutions. This article explores two desiderata for such justifications. The first is a formal equality baseline which puts the burden of justification on those who favour more unequal institutions. This baseline is seen as an implication of the rule of law. The second desideratum, the comparison requirement, builds on the first: adequate justifications of particular institutions must compare them to the best alternative, and this comparison must consider the costs for political equality. The two desiderata are applied to political science debates about the proportionality of the electoral system and bicameral systems of legislative decision-making.
The role of SRC‐CAS interactions in cellular transformation: Ectopic expression of the carboxy terminus of CAS inhibits SRC‐CAS interaction but has no effect on cellular transformation

Several lines of evidence indicate that the adapter molecule p130CAS (crk‐associated substrate (CAS)) is required for src‐mediated cellular transformation. CAS has been shown to be heavily tyrosine‐phosphorylated in src‐transformed cells, and genetic variants of src that are deficient in CAS binding are also unable to mediate cellular transformation. In this report, we investigated whether CAS phosphorylation and/or its association with src are required elements of the transformation process. Expression of the carboxy‐terminal src binding domain of CAS in Rat 1 fibroblasts expressing a temperature‐sensitive allele of v‐src inhibited the formation of src‐CAS complexes and also inhibited tyrosine phosphorylation of CAS. However, expression of this protein had no effect on morphological transformation, src‐mediated actin rearrangements, or anchorage‐independent growth of these cells when grown at the src‐permissive temperature. Thus, the ability of activated src to mediate cellular transformation is either largely independent of endogenous CAS phosphorylation and/or its association with CAS or, alternatively, the carboxy‐terminus of CAS may substitute for endogenous CAS in the process of src‐mediated transformation. Mol. Carcinog. 26:20–31, 1999. © 1999 Wiley‐Liss, Inc.
Semantic Frames in Romanian Natural Language Processing Systems

A method for producing a plastic material from a water-in-oil emulsion of an unsaturated polyester resin dissolved in a hardenable compound containing an ethylenically unsaturated group. The emulsion has an adjusted viscosity of 1600-5000 cp. The plastic material is suitable as a replacement for plaster in the shaping of ceramics. The emulsion may contain an alkali-reactive water-binding material to increase the ceramic forming capability of the plastic material.
Techniques and applications of skeletal muscle diffusion tensor imaging: A review

Diffusion tensor imaging (DTI) is increasingly applied to study skeletal muscle physiology, anatomy, and pathology. The reason for this growing interest is that DTI offers unique, noninvasive, and potentially diagnostically relevant imaging readouts of skeletal muscle structure that are difficult or impossible to obtain otherwise. DTI has been shown to be feasible within most skeletal muscles. DTI parameters are highly sensitive to patient‐specific properties such as age, body mass index (BMI), and gender, but also to more transient factors such as exercise, rest, pressure, temperature, and relative joint position. However, when designing a DTI study one should not only be aware of sensitivity to the above‐mentioned factors but also the fact that the DTI parameters are dependent on several acquisition parameters such as echo time, b‐value, and diffusion mixing time. The purpose of this review is to provide an overview of DTI studies covering the technical, demographic, and clinical aspects of DTI in skeletal muscles. First we will focus on the critical aspects of the acquisition protocol. Second, we will cover the reported normal variance in skeletal muscle diffusion parameters, and finally we provide an overview of clinical studies and reported parameter changes due to several (patho‐)physiological conditions. J. Magn. Reson. Imaging 2016;43:773–788
Classical approximation to quantum cosmological correlations

We investigate up to which order quantum effects can be neglected in calculating cosmological correlation functions after horizon exit. We study, as a toy model, ϕ3 theory on a de Sitter background for a massless minimally coupled scalar field ϕ. We find that for tree level and one loop contributions in the quantum theory, a good classical approximation can be constructed, but for higher loop corrections this is in general not expected to be possible. The reason is that loop corrections get non-negligible contributions from loop momenta with magnitude up to the Hubble scale H, at which scale classical physics is not expected to be a good approximation to the quantum theory. An explicit calculation of the one loop correction to the two point function supports the argument that contributions from loop momenta of scale H are not negligible. Generalization of the arguments for the toy model to derivative interactions and the curvature perturbation leads to the conclusion that the leading orders of non-Gaussian effects generated after horizon exit can be approximated quite well by classical methods. Furthermore we compare with a theorem of Weinberg. We find that growing loop corrections after horizon exit are not excluded, even in single field inflation.
Leucine Zipper Down-regulated in Cancer-1 (LDOC1) interacts with Guanine nucleotide binding protein-like 3-like (GNL3L) to modulate Nuclear Factor-kappa B (NF-κB) signaling during cell proliferation

ABSTRACT Guanine nucleotide binding protein-like 3-like (GNL3L) is an evolutionarily conserved putative nucleolar GTPase belonging to the HSR1-MMR1 family. In the present study, using protein-protein interaction assays, we show that Leucine Zipper Down-regulated in Cancer-1 (LDOC1) is a novel interacting partner of GNL3L. Furthermore, our results reveal that ectopic expression of LDOC1 destabilizes endogenous GNL3L levels and down modulates GNL3L-induced cell proliferation, in contrast, the knockdown of LDOC1 potentiates cell proliferation upon GNL3L expression. Interestingly, GNL3L upregulates NF-κB dependent transcriptional activity by modulating the expression of NF-κB subunit p65, which is reversed upon co-expression of LDOC1 with GNL3L. GNL3L also potentiates TNF-α mediated NF-κB activity. In addition, anti-apoptotic function of GNL3L is impaired upon p65 knockdown, suggesting its critical role in GNL3L mediated cell proliferation/survival. An inverse correlation of GNL3L and LDOC1 expression profiles in various tumor tissues from BioXpress database indicate their critical role in cancer. Collectively, our data provides evidence that GNL3L-LDOC1 interplay regulates cell proliferation through the modulation of NF-κB pathway during tumorigenesis.
Power optimization of delay constrained circuits

We present a framework for combining Voltage Scaling (VS) and Gate Sizing (GS) techniques for power optimizations. We introduce a fast algorithm for choosing gates for sizing and voltage scaling such that the total power is minimized under delay constraints. We also use a more accurate estimate for determining the power dissipation of the circuit by taking into account the short circuit power along with the dynamic power. A better model of the short circuit power is used which takes into account the loading capacitance of the gates. Our results show that the combination of VS and GS perform better than the techniques applied in isolation. An average power reduction of 73% is obtained when decisions are taken assuming dynamic power only. In contrast, average power reduction is 77% when decisions include the short circuit power dissipation.
Approximation of transmission line parameters of single-core and three-core XLPE cables

A transmission line model of a power cable is required for the analysis of the behavior of high-frequency phenomena, such as partial discharges, lightning impulses and switching transients, in cables. A transmission line is characterized by its characteristic impedance, attenuation coefficient and propagation velocity. The semiconducting layers in an XLPE cable have a significant influence on these parameters. Unfortunately, the dielectric properties of these layers are usually unknown and can differ between similar types of cables. In this paper it is shown that nevertheless the characteristic impedance and propagation velocity of single-core and three-core XLPE cables can be estimated using available information from the cable specifications. The estimated values are validated using pulse response measurements on cable samples.
Beginning Teachers’ Motivations and Aspirations through Teacher Education

ABSTRACT: Much research has focused on what motivates people to take on a teaching career. An open question remains – how do their motivations and aspirations change through their professional education? We sampled secondary teacher education candidates near the end of their qualification (N=72) in Melbourne Australia (age: M=21.44, SD 2.77). Participants rated their responses for “then” (recalling their entry to teacher education) and “now” for a range of items. They answered open-ended questions regarding future plans and aspirations, and their teaching related abilities. Responses revealed significant changes in most perceived motivations and aspirations, with all changes in an upward direction. Findings are interpreted in light of the current climate of teacher shortages.