Miracle-dz/UniFAR-FTUs huggingface dataset:
Adiponectin Action: A Combination of Endocrine and Autocrine/Paracrine Effects

The widespread physiological actions of adiponectin have now been well characterized as clinical studies and works in animal models have established strong correlations between circulating adiponectin level and various disease-related outcomes. Thus, conventional thinking attributes many of adiponectin’s beneficial effects to endocrine actions of adipose-derived adiponectin. However, it is now clear that several tissues can themselves produce adiponectin and there is growing evidence that locally produced adiponectin can mediate functionally important autocrine or paracrine effects. In this review article we discuss regulation of adiponectin production, its mechanism of action via receptor isoforms and signaling pathways, and its principal physiological effects (i.e., metabolic and cardiovascular). The role of endocrine actions of adiponectin and changes in local production of adiponectin or its receptors in whole body physiology is discussed.
Naturalistic Evaluation: Its Tenets and Application

This paper considers naturalistic evaluation as a form of qualitative inquiry and discusses its relationship to other qualitative pursuits. A description of the naturalistic evaluation process is followed by a discussion of the philosophical and methodological bonds that exist between such fields as ethnography, educational criticism, and naturalistic evaluation. The value and potential for using naturalistic evaluation in art education is then explored.
What H.M. Taught Us

Studies on H.M. generated five main findings: that memory is a distinct psychological function, that amnesia spares short-term and working memory, that amnesia is an impairment of declarative and episodic memory, that the hippocampus is a core brain structure supporting memory, and that the hippocampus supports the permanent consolidation of memories. Each of these basic findings has recently been challenged, but a consideration of these studies suggests the new observations serve to support the original findings on H.M. and improve our understanding of the memory functions of the hippocampal system.
Pressure independence of renin release by isolated kidneys of Lyon hypertensive rats.

In the present work the influence of perfusion pressure on renal functions and renin release was studied before and after the blockade of thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptors using isolated kidneys from 7-week-old genetically hypertensive (LH), normotensive (LN), and low blood pressure (LL) rats of the Lyon strain. Kidneys were single pass perfused with Krebs-Henseleit solution with a gelatine derivative (Polygeline) added as an oncotic agent. A servocontrolled system stabilized the renal perfusion pressure (RPP) at any chosen (+/- 1 mm Hg) level. In baseline conditions (RPP, 90 mm Hg), LH (n = 7) kidneys differed from LN (n = 6) and LL (n = 8) controls by increased vascular resistance, decreased glomerular filtration rate, and natriuresis. The LH kidney responses to stepwise changes in RPP (between 60 and 170 mm Hg) differed from those of LN and LL rats by a significantly lower perfusion flow, glomerular filtration rate, and natriuresis. Above all, the reduction in RPP, which induced a marked and highly reproducible renin release in LN and LL kidneys, was devoid of effects in LH kidneys. The blockade of TXA2/PGH2 receptors by AH23848 (4 x 10(-6) M) did not change the baseline (RPP, 90 mm Hg) functions of kidneys of the three strains. During changes in RPP, the responses of LN and LL kidneys were not modified, whereas LH kidneys exhibited significant increases in both glomerular filtration rate and natriuresis. Finally, AH23848 significantly decreased the renin release by kidneys of the three strains. (ABSTRACT TRUNCATED AT 250 WORDS)
Genetic and Linguistic Coevolution in Northern Island Melanesia

Recent studies have detailed a remarkable degree of genetic and linguistic diversity in Northern Island Melanesia. Here we utilize that diversity to examine two models of genetic and linguistic coevolution. The first model predicts that genetic and linguistic correspondences formed following population splits and isolation at the time of early range expansions into the region. The second is analogous to the genetic model of isolation by distance, and it predicts that genetic and linguistic correspondences formed through continuing genetic and linguistic exchange between neighboring populations. We tested the predictions of the two models by comparing observed and simulated patterns of genetic variation, genetic and linguistic trees, and matrices of genetic, linguistic, and geographic distances. The data consist of 751 autosomal microsatellites and 108 structural linguistic features collected from 33 Northern Island Melanesian populations. The results of the tests indicate that linguistic and genetic exchange have erased any evidence of a splitting and isolation process that might have occurred early in the settlement history of the region. The correlation patterns are also inconsistent with the predictions of the isolation by distance coevolutionary process in the larger Northern Island Melanesian region, but there is strong evidence for the process in the rugged interior of the largest island in the region (New Britain). There we found some of the strongest recorded correlations between genetic, linguistic, and geographic distances. We also found that, throughout the region, linguistic features have generally been less likely to diffuse across population boundaries than genes. The results from our study, based on exceptionally fine-grained data, show that local genetic and linguistic exchange are likely to obscure evidence of the early history of a region, and that language barriers do not particularly hinder genetic exchange. In contrast, global patterns may emphasize more ancient demographic events, including population splits associated with the early colonization of major world regions.
THE CATABOLISM OF HOMOLOGOUS AND HETEROLOGOUS 7S GAMMA GLOBULIN FRAGMENTS

The catabolism of homologous and heterologous 7S gamma globulin fragments obtained by pepsin and papain digestion was studied in rabbits, guinea pigs, and mice. The elimination from the circulation of I* labeled gamma globulin fragments was followed and the urinary excretion of the total and protein-bound I* activity determined. Evidence is presented that the molecular structure responsible for the catabolism of 7S gamma globulin is located in papain fragment III. The elimination of papain fragment III was slow and closely related to the intact gamma globulin, whereas the pepsin fragment and papain fragments I and II were rapidly eliminated and catabolized in all species examined. Prolonged incubation with cysteine altered papain fragment III as shown by a rapid catabolism of a large portion of incubated fragment III within 24 hours after injection. Small amounts of intact RGG and RGG papain fragment III were excreted as protein-bound I* activity in the urine. On the other hand, large amounts of the pepsin fragment and papain fragments I and II of RGG were excreted as protein-bound I* activity in the urine. The possibility of a molecular structure present in papain fragment III, which may be responsible for tubular reabsorption in the kidney, is discussed. The rate of urinary excretion of fragments obtained from RGG was different from that of fragments obtained from gamma globulin of several other species. In general, small amounts of the pepsin fragment and papain fragment III obtained from gamma globulin other than RGG were excreted as protein-bound I* activity. The amounts of fragment I* excreted as protein-bound I* activity depended on the species in which it was injected, as well as the source of the gamma globulin. The rapid catabolism of the pepsin fragment and papain fragments I or II which bear antibody-combining sites suggest that their use for the prophylactic treatment of tetanus and diphtheria in man is limited.
Empirical Evaluation of “ Hard ” and “ Soft ” Label Propagation in Relational Classification

Most relational classifiers utilize some sort of label propagation for iterative inference. In this paper we differentiate between “hard” and “soft” label propagation. The latter method assigns probabilities or class-membership scores to data instances, then propagates these scores throughout the networked data, whereas the former works by explicitly propagating class labels at each iteration. We present a comparative empirical study of these methods applied to a relational binary classification task. We evaluate two approaches on both synthetic and real–world relational data. Our results indicate that while neither approach dominates the other over the entire range of input data parameters, there are some interesting and non–trivial tradeoffs between them.
DynamicMaps: Similarity-based Browsing through a Massive Set of Images

We present a novel system for browsing through a very large set of images according to similarity. The images are dynamically placed on a 2D canvas next to their nearest neighbors in a high-dimensional feature space. The layout and choice of images is generated on-the-fly during user interaction, reflecting the user's navigation tendencies and interests. This intuitive solution for image browsing provides a continuous experience of navigating through an infinite 2D grid arranged by similarity. In contrast to common multidimensional embedding methods, our solution does not entail an upfront creation of a full global map. Image map generation is dynamic, fast and scalable, independent of the number of images in the dataset, and seamlessly supports online updates to the dataset. Thus, the technique is a viable solution for massive and constantly varying datasets consisting of millions of images. Evaluation of our approach shows that when using DynamicMaps, users viewed many more images per minute compared to a standard relevance feedback interface, suggesting that it supports more fluid and natural interaction that enables easier and faster movement in the image space. Most users preferred DynamicMaps, indicating it is more exploratory, better supports serendipitous browsing and more fun to use
The Long-Term Effect of Coronary Stenting on Epicardial and Microvascular Endothelial Function

Background— Coronary stents, drug-eluting stents in particular, have been linked to coronary epicardial endothelial dysfunction after implantation. However, less is known about their impact on coronary microvascular function and their long-term effects on the vasculature. Methods and Results— We evaluated 71 patients (mean age, 53.0±10.1 years) with chest pain and angiographically nonsignificant coronary artery disease 17.1±17.1 months after left anterior descending coronary artery stenting. Seventy-one age- and sex-matched patients (mean age, 53.0±10.3 years) with chest pain but no prior coronary intervention served as controls. Coronary blood flow in response to the endothelium-dependent vasodilator acetylcholine as well as the microvascular (endothelium-independent) coronary flow reserve in response to intracoronary adenosine were evaluated. Quantitative coronary angiography was used to study epicardial diameter changes to acetylcholine. Microcirculatory function was not significantly different between the stenting and control groups (median [interquartile range] coronary flow reserve, 2.9 [2.5–3.4] versus 3.0 [2.4–3.4] mL/min, P=0.24; change of coronary blood flow, 34.9% [−34.4% to 90.0%] versus 54.7% [−5.6% to 104.6%], P=0.18). Both groups exhibited epicardial endothelial dysfunction (−23.0% [−47.4% to −7.6%] versus −20.0% [−40.0% to 0.0%], P=0.4). Results did not differ between patients with drug-eluting stents (n=46) and patients with bare-metal stents (n=24). Conclusions— This study demonstrates that in patients with coronary arteries in which a stent has been placed, coronary microcirculatory and epicardial vascular function are not significantly different from that of an age- and sex-matched population with similar symptoms but nonsignificant coronary artery disease.
Effects of Bandwidth Feedback and Questioning on the Performance of Competitive Swimmers

The effects of a coaching intervention involving Bandwidth Feedback and Questioning (BF-Q) on competitive swim times (cTIME), practice swim times (pTIME), and technique (TECH) were determined for competitive youth swimmers. The pre-post-transfer design spanned one short-course (25m) swim season. It was concluded that coaching in which feedback was delayed and replaced with questions directed to the athletes contributed to improved technique and subsequent faster race times. Compared to the Control group, the BF-Q group displayed greater gains in TECH during the intervention period and greater improvement in cTIME during the transfer period. Results are presented in a context of cognitive psychology, motor learning, and questioning. Applications to coaching practice and coach training are also discussed.
Exploiting co-location history for efficient service selection in ubiquitous computing systems

As the ubiquitous computing vision materializes, the number and diversity of digital elements in our environment increases. Computing capability comes in various forms and is embedded in different physical objects, ranging from miniature devices such as human implants and tiny sensor particles, to large constructions such as vehicles and entire buildings. The number of possible interactions among such elements, some of which may be invisible or offer similar functionality, is growing fast so that it becomes increasingly hard to combine or select between them. Mechanisms are thus required for intelligent matchmaking that will achieve controlled system behavior, yet without requiring the user to continuously input desirable options in an explicit manner. In this paper we argue that information about the co-location relationship of computing elements is quite valuable in this respect and can be exploited to guide automated service selection with minimal or no user involvement. We also discuss the implementation of such mechanism that is part of our runtime system for smart objects.
Backtracking Procedures for Hypertree, HyperSpread and Connected Hypertree Decomposition of CSPs

Hypertree decomposition has been shown to be the most general CSP decomposition method. However, so far the exact methods are not able to find optimal hypertree decompositions of realistic instances. We present a backtracking procedure which, along with isomorphic component detection, results in optimal hypertree decompositions. We also make the procedure generic; variations of which results in two new tractable decompositions: hyperspread and connected hypertree. We show that the hyperspread width is bounded by both the hypertree width and the spread cut width, which solves a recently stated open problem. In our experiments on several realistic instances, our methods find many optimal decompositions, while the previous methods can find at most one.
Comparing the imitative skills of children and nonhuman apes

We propose a framework which breaks down the mechanisms of social learning into their four constituent elements: actions, results, goals, and context. We review what is known about the use of each of these elements in children’s and apes’ social learning, with special attention to possible differences among apes with different rearing histories. We conclude that, by 12 months of age, human infants use each of the four elements when interpreting and selectively copying others’ behavior. Apes, on the other hand, appear to focus solely on the results of demonstrations (although there is some suggestive evidence that enculturated apes may copy actions and goals more than other apes). Finally, we show how these (and other related) findings can be explained by uniquely human skills and motivations for shared intentionality.
Capacity efficiency of sub-wavelength traffic grooming in IP over Quasi-CWDM optical networks (invited)

We proposed a new Quasi-CWDM optical network architecture which is spectrum efficient and cost effective [1]. Similar to the traditional DWDM network, the new network architecture does not require expensive flex-grid wavelength selective switches (WSSs), but can support optical super-channels using fixed quasi-coarse WDM grids, of which each spans at least 200 GHz. For each optical super-channel in the Quasi-CWDM network, different modulation formats can be adaptively used based on their bit-rate requirements and channel physical conditions. In [1], we have evaluated the performance of the Quasi-CWDM network architecture from the cost perspective. In this study, we will evaluate the performance for the Quasi-CWDM optical network in terms of capacity efficiency. We consider sub-wavelength traffic grooming in an IP over Quasi-CWDM network. A mixed integer linear programming (MILP) optimization model is developed to maximize the total served IP traffic demand. In addition, the capacity efficiency is evaluated through discrete event simulations to find bandwidth blocking probability when using the Quasi-CWDM network to provision dynamic sub-wavelength traffic demand. The results show that the Quasi-CWDM network is more capacity-efficient than the DWDM optical network to accommodate more sub-wavelength traffic demand and shows the lowest bandwidth blocking probability under different minimum elastic channel bandwidths while having a lower hardware cost than the elastic optical network (EON).
A short review and primer on multimodal psychophysiological applications in work-related human computer interaction

The application of psychophysiology in human-computer interaction is a growing field with significant potential for future smart personalised systems. Working in this emerging field requires comprehension of an array of physiological signals and analysis techniques. This paper focuses on the aggregation of multiple physiological measurements, obtained from one or more sensors. This approach requires the classification of relatively large samples of multidimensional data, which must be associated to specific cognitive or affective states. Researchers generally attempt to solve this problem by utilising machine learning techniques. We present a short review to serve as a primer for the novice, enabling rapid familiarisation with the latest core concepts. We put special emphasis on work-related human-computer interface applications to distinguish from the more common clinical or sports uses of psychophysiology. This paper is an extract from a comprehensive review of the entire field of ambulatory psychophysiology, including 12 similar chapters, plus application guidelines and systematic review. Thus any citation should be made using the following reference: B. Cowley, M. Filetti, K. Lukander, J. Torniainen, A. Henelius, L. Ahonen, O. Barral, I. Kosunen, T. Valtonen, M. Huotilainen, N. Ravaja, G. Jacucci. The Psychophysiology Primer: a guide to methods and a broad review with a focus on human-computer interaction. Foundations and Trends in Human-Computer Interaction, vol. 9, no. 3-4, pp. 150--307, 2016.
NPM1 mutations are more stable than FLT3 mutations during the course of disease in patients with acute myeloid leukemia

NPM1 mutations have been reported to be the most frequent mutations in acute myeloid leukemia (AML). They are associated with a wide spectrum of morphologic subtypes of AML, normal karyotype and FLT3 mutations. The high frequency of NPM1 mutations might provide a suitable marker for monitoring residual disease of AML.
Multimodal and ubiquitous computing systems: supporting independent-living older users

We document the rationale and design of a multimodal interface to a pervasive/ubiquitous computing system that supports independent living by older people in their own homes. The Millennium Home system involves fitting a resident's home with sensors-these sensors can be used to trigger sequences of interaction with the resident to warn them about dangerous events, or to check if they need external help. We draw lessons from the design process and conclude the paper with implications for the design of multimodal interfaces to ubiquitous systems developed for the elderly and in healthcare, as well as for more general ubiquitous computing applications.
Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family

Cytokine-stimulated human osteosarcoma cells (MG-63) secrete several related chemotactic factors, including the neutrophil-activating protein interleukin 8 (IL-8) and the monocyte chemotactic protein (MCP)- 1. We describe the isolation and characterization of two novel monocyte chemotactic factors from this tumor cell line. Although these proteins copurified with MCP-1 and IL-8 on heparin-Sepharose, they could be separated by cation-exchange fast protein liquid chromatography and reverse-phase high-performance liquid chromatography. The corresponding 7.5- and 11-kD proteins were NH2-terminally blocked but were identified by sequencing peptide fragments. They showed a primary structure mostly related to that of MCP-1 and were therefore designated MCP-2 and MCP-3, respectively. These molecules can be classified in a subfamily of proinflammatory proteins characterized by the conservation of cysteine residues. MCP-2 and MCP-3 are also functionally related to MCP-1 because they specifically attract monocytes, but not neutrophils, in vitro. The chemotactic potency (specific activity) was comparable for all three MCPs. Intradermal injection of these proteins in rabbits resulted in selective monocyte recruitment in vivo. Since tumor cells are good producers of leukocyte chemotactic factors, it could be questioned whether these molecules can indirectly control tumor growth by attracting leukocytes or whether they rather promote invasion by the secretion of proteases from the attracted cells.
Qualitative versus quantitative blood cultures in the diagnosis of catheter‐related bloodstream infections in children with malignancy

Paired quantitative and qualitative blood cultures have been introduced for the diagnosis of catheter‐related bloodstream infections (CRBI) with the catheter in situ. The aim of the study was to compare the diagnostic performance and the prognostic value of the two methods in the evaluation of febrile episodes without an apparent source in children with cancer.
Multimodal Biometric System Using Face-Iris Fusion Feature

With the wide application, the performance of unimodal biometrics systems has to contend with a variety of problems such as background noise, signal noise and distortion, and environment or device variations. Therefore, multimodal biometric systems are proposed to solve the above mentioned problems. This paper proposed a novel multimodal biometric system using face-iris fusion feature. Face feature and iris feature are first extracted respectively and fused in feature-level. However, existing feature level schemes such as sum rule and weighted sum rule are inefficient in complicated condition. In this paper, we adopt an efficient feature-level fusion scheme for iris and face in series. The algorithm normalizes the original features of iris and face using z-score model to eliminate the unbalance in the order of magnitude and the distribution between two different kinds of feature vectors, and then connect the normalized feature vectors in serial rule. The proposed algorithm is tested using CASIA iris database and two face databases (ORL database and Yale database). Experimental results show the effectiveness of the proposed algorithm.