Miracle-dz/UniFAR-FTUs huggingface dataset:
LA STRUCTURE DU POUVOIR COMMUNAL D'UNE MICRO-REGION RURALE EN CHANGEMENT.: LE CLOS-DU-DOUBS EN SUISSE

Summary THE STRUCTURE OF VILLAGE POWER IN A CHANGING RURAL MICRO-REGION LE CLOS-DU-DOUBS IN SWITZERLAND Three essential dimensions, which do not necessarily overlap, permit to differentiate the eight communes of the region under study; the rural-urban continuum, the conflict-consensus continuum, the power relations of three socio-political groups, for this purpose baptized radicals (the individuals desiring a radical change), reformists and integrationists. The numerous conflicts developing in this micro-region depend mainly of three factors: the intensity of change, the social and cultural heterogenity, and the ecological dispersion. The economic and social transformations of these communes and of their region have modified the local power structure (disappearance of certain social actors and strengthened the position of others). The weakening of village autonomy in favour of the central government is another consequence of these changes. RESUME LA STRUCTURE DU POUVOIR COMMUNAL D'UNE MICRO-REGION RURALE EN CHANGEMENT LE CLOS-DU-DOUBS EN SUISSE Trois dimensions essentielles, qui ne se coupent pas necessairement, permettent de differencier les huit communes de la region etudiee; le continuum rural-urbain, le continuum consensuel-conflictucl, les rapports de force de trois groupes soul politiques, baptises pour la circonstance radicaux (les individus desirant un hgement radical), riformistes et integristes. Les nombrew conflits, qui se developpent dans cette microregion, dependent principalement de trois factem: l'intensite du changement, l'heterogeneite sociale et culturelle et la dispersion ecologique. Les transformations economiques et sociales de ces communes et de la region dans laquelle elles s'inscrivent ont modifie tres sensiblement la structure du pouvoir local (disparition de certains acteurs sociaux et renforcement d'autres). L'affaiblissement de l'autonomie communale au profit de 1'Etat central est une autre consequence de ces changements. ZUSAMMENFASSUNG DIE KOMMUNALE MACHTSTRUKTUR EINER LATNDLICHEN KLEINREGION IM WANDEL DAS BEBIET DES CLOS-DU-DOUBS IN DER SCHWEIZ Drei wesentliche Dimensionen, die sich nicht notwendigerweise uberschneidcn, erlauben die 8 Gemeinden der untcrsuchten Region zu differenzieren; das landlich-stadtische Continuum, das Consensus-Konflikt-Continuum, die Starkeverhatnisse der drei sozio-politischen Gruppen, die fur diesen Zweck Radikale (diejenigen, die eine radikale Anderung wunschen), Reformisten und Integristen genannt werden. Die zahlreichen Konflikte, die sich in dieser Kleinrcgion entwickeln, hangen hauptsachlich von drei Faktoren ab: Intensiat des Wandels, soziale und kulturelle Integritat und okologische Unterschiedlichkeit. Die okonomischen und sozialen Veranderungen dieser Ganeinden und der Region, in der sie liegen, haben sehr wcsentlich die Struktur der lokalen Macht modifiziert (Verschwinden gewisser sozialer Akteure und Verstarkung anderer). Die Schwachung der kommunalen Autonomie zugunsten des zentralen Staates ist cine andere Konsequenz dieser Wandlungen.
Purification and characterization of acetoin:2,6-dichlorophenolindophenol oxidoreductase, dihydrolipoamide dehydrogenase, and dihydrolipoamide acetyltransferase of the Pelobacter carbinolicus acetoin dehydrogenase enzyme system

Dihydrolipoamide dehydrogenase (DHLDH), dihydrolipoamide acetyltransferase (DHLTA), and acetoin: 2,6-dichlorophenolindophenol oxidoreductase (Ao:DCPIP OR) were purified from acetoin-grown cells of Pelobacter carbinolicus. DHLDH had a native Mr of 110,000, consisted of two identical subunits of Mr 54,000, and reacted only with NAD(H) as a coenzyme. The N-terminal amino acid sequence included the flavin adenine dinucleotide-binding site and exhibited a high degree of homology to other DHLDHs. DHLTA had a native Mr of greater than 500,000 and consisted of subunits identical in size (Mr 60,000). The enzyme was highly sensitive to proteolytic attack. During limited tryptic digestion, two major fragments of Mr 32,500 and 25,500 were formed. Ao:DCPIP OR consisted of two different subunits of Mr 37,500 and 38,500 and had a native Mr in the range of 143,000 to 177,000. In vitro in the presence of DCPIP, it catalyzed a thiamine pyrophosphate-dependent oxidative-hydrolytic cleavage of acetoin, methylacetoin, and diacetyl. The combination of purified Ao:DCPIP OR, DHLTA, and DHLDH in the presence of thiamine pyrophosphate and the substrate acetoin or methylacetoin resulted in a coenzyme A-dependent reduction of NAD. In the strictly anaerobic acetoin-utilizing bacteria P. carbinolicus, Pelobacter venetianus, Pelobacter acetylenicus, Pelobacter propionicus, Acetobacterium carbinolicum, and Clostridium magnum, the enzymes Ao:DCPIP OR, DHLTA, and DHLDH were induced during growth on acetoin, whereas they were absent or scarcely present in cells grown on a nonacetoinogenic substrate.
A Dynein-dependent shortcut rapidly delivers axis determination transcripts into the Drosophila oocyte

The primary axes of Drosophila are set up by the localization of transcripts within the oocyte. These mRNAs originate in the nurse cells, but how they move into the oocyte remains poorly understood. Here, we study the path and mechanism of movement of gurken RNA within the nurse cells and towards and through ring canals connecting them to the oocyte. gurken transcripts, but not control transcripts, recruit the cytoplasmic Dynein-associated co-factors Bicaudal D (BicD) and Egalitarian in the nurse cells. gurken RNA requires BicD and Dynein for its transport towards the ring canals, where it accumulates before moving into the oocyte. Our results suggest that bicoid and oskar transcripts are also delivered to the oocyte by the same mechanism, which is distinct from cytoplasmic flow. We propose that Dynein-mediated transport of specific RNAs along specialized networks of microtubules increases the efficiency of their delivery, over the flow of general cytoplasmic components, into the oocyte.
Multiple Sklerose: Fatigue

Zusammenfassung Fatigue, eine vermehrte Ermüdbarkeit und subjektiver Mangel an Energie, ist eines der häufigsten und beeinträchtigendsten Symptome bei der Multiplen Sklerose. Sie beeinflusst wesentlich die Alltagsaktivitäten. Fatigue zeigt nur eine schwache Korrelation mit dem Grad der physischen Behinderung, ist aber häufig mit einer Depression vergesellschaftet. Die zu Grunde liegende genaue Pathophysiologie ist bislang unbekannt. Ursächlich werden das Ausmaß des axonalen Verlustes bzw. der Hirnatrophie, neuroendokrine Veränderungen durch proinflammatorische Prozesse sowie ein erhöhter Energiebedarf diskutiert. Die Therapie sollte multimodal und schrittweise gestaltet werden. Dazu stehen Verhaltensmodifikationen (z.B. Vermeidung von Überwärmung, Energieökonomie, Pausen, Schafregulation), moderates körperliches Training (aerobe Fitness), die Behandlung begleitender depressiver Symptome (Psychotherapie, Antidepressiva) sowie der Einsatz symptomatischer Medikamente, vor allem Amantadin oder Modafinil, zur Verfügung.
L-band ice-sheet brightness temperatures at Dome C, Antarctica: spectral emission modelling, temporal stability and impact of the ionosphere

Abstract The temporal thermal stability, size, structure and spatial uniformity of Antarctic Plateau regions such as Dome C make them ideal candidates for external calibration and validation, or radiometric performance monitoring of planned space-borne L-band radiometers such as the Soil Moisture and Ocean Salinity (SMOS) radiometer. As experimental observations do not exist at this frequency, a combination of historical Ka-, X- and C-band data are used together with electromagnetic and ionospheric models to extrapolate to this longer wavelength. Dome C is demonstrated to exhibit negligible seasonal variability (<0.1 K) and may prove to be a suitable candidate, provided the effects of atmospheric and ionospheric perturbations can be mitigated.
EVOLUTIONARY INFERENCES FROM THE ANALYSIS OF EXCHANGEABILITY

Evolutionary inferences are usually based on statistical models that compare mean genotypes or phenotypes (or their frequencies) among populations. An alternative is to use the full distribution of genotypes and phenotypes to infer the “exchangeability” of individuals among populations. We illustrate this approach by using discriminant functions on principal components to classify individuals among paired lake and stream populations of threespine stickleback in each of six independent watersheds. Classification based on neutral and nonneutral microsatellite markers was highest to the population of origin and next highest to populations in the same watershed. These patterns are consistent with the influence of historical contingency (separate colonization of each watershed) and subsequent gene flow (within but not between watersheds). In comparison to this low genetic exchangeability, ecological (diet) and morphological (trophic and armor traits) exchangeability was relatively high—particularly among populations from similar habitats. These patterns reflect the role of natural selection in driving parallel adaptive changes when independent populations colonize similar habitats. Importantly, however, substantial nonparallelism was also evident. Our results show that analyses based on exchangeability can confirm inferences based on statistical analyses of means or frequencies, while also refining insights into the drivers of—and constraints on—evolutionary diversification.
Effect of C7 Modifications on Benzothiadiazine‐1,1‐dioxide Derivatives on Their Inhibitory Activity and Selectivity toward Aldose Reductase

The development and progression of chronic complications in diabetic patients, such as retinopathy, nephropathy, neuropathy, cataracts, and stroke, are related to the activation and/or overexpression of aldose reductase (ALR2), which is a member of the aldo–keto reductase superfamily. A structure–activity relationship study focused on the C7 position of 1,2,4‐benzothiadiazine‐1,1‐dioxide derivatives was pursued in an attempt to discover ALR2 inhibitors with enhanced potency and selectivity. These studies led to a series of new C7‐substituted compounds, which were evaluated for their inhibitory activity against ALR2; they exhibited IC50 values in the range of 2.80–45.13 nM. Two compounds with a C7‐dimethylcarbamoyl and a C7‐diethylcarbamoyl substituent, respectively, were found to be the most active and presented excellent selectivity for ALR2 over aldehyde reductase (ALR1). The structure–activity relationship analyses and molecular modeling studies presented herein highlight the importance of hydrophobic and bulky groups at the C7 position for inhibitory activity and selectivity toward ALR2.
A Comparative Study of Energy Management Schemes for a Fuel-Cell Hybrid Emergency Power System of More-Electric Aircraft

This paper presents a comparative analysis of different energy management schemes for a fuel-cell-based emergency power system of a more-electric aircraft. The fuel-cell hybrid system considered in this paper consists of fuel cells, lithium-ion batteries, and supercapacitors, along with associated dc/dc and dc/ac converters. The energy management schemes addressed are state of the art and are most commonly used energy management techniques in fuel-cell vehicle applications, and they include the following: the state machine control strategy, the rule-based fuzzy logic strategy, the classical proportional-integral control strategy, the frequency decoupling/fuzzy logic control strategy, and the equivalent consumption minimization strategy. The main criteria for performance comparison are the hydrogen consumption, the state of charges of the batteries/supercapacitors, and the overall system efficiency. Moreover, the stresses on each energy source, which impact their life cycle, are measured using a new approach based on the wavelet transform of their instantaneous power. A simulation model and an experimental test bench are developed to validate all analysis and performances.
Program Committee

1 The talk will start and go around this claim: “Could a business think? ” and mainly explore what cognitive computing is starting to provide an added value as diverse industries. Main focus will be how cognitive computing is impacting financial services and hot it could contribute to reshape that industry 1 IBM. email: pietro_leo@it.ibm. com
Travel Agency: A Critique of Anti-Trafficking Campaigns

This paper offers a critical evaluation of anti-trafficking campaigns spearheaded by some in the feminist movement in an attempt to deal with the issues of unsafe migrations and labour exploitation. I discuss how calls to “end trafficking, especially in women and children” are influenced by – and go on to legitimate – governmental practices to criminalize the self-willed migration of people moving without official permission. I discuss how the ideological frame of anti-trafficking works to reinforce restrictive immigration practices, shore up a nationalized consciousness of space and home, and criminalize those rendered illegal within national territories. Anti-trafficking campaigns also fail to take into account migrants’ limited agency in the migration process. I provide alternative routes to anti-trafficking campaigns by arguing for an analytical framework in which the related worldwide crises of displacement and migration are foregrounded. I argue that by centering the standpoint of undocumented migrants a more transformative politics emerges, one that demands that people be able to “stay” and to “move” in a self-determined manner.
Contention resolution with constant expected delay

We study contention resolution in a multiple-access channel such as the Ethernet channel. In the model that we consider, n users generate messages for the channel according to a probability distribution. Raghavan and Upfal have given a protocol in which the expected delay (time to get serviced) of every message is O(log n) when messages are generated according to a Bernoulli distribution with generation rate up to about 1/10. Our main results are the following protocols: (a) one in which the expected average message delay is O(1) when messages are generated according to a Bernoulli distribution with a generation rate smaller than 1/e, and (b) one in which the expected delay of any message is O(1) for an analogous model in which users are synchronized (i.e., they agree about the time), there are potentially an infinite number of users, and messages are generated according to a Poisson distribution with generation rate up to 1/e. (Each message constitutes a new user.) To achieve (a), we first show how to simulate (b) using n synchronized users, and then show how to build the synchronization into the protocol.
Defense Mechanisms versus Openness to Experience: Implications for Counselling

A comparison is made of theories that view defense mechanisms as adaptive processes that promote mental health and those that define absence of defense and openness as criteria of positive life adjustment. Adaptive functions of defense mechanisms are related to providing stability and continuity, protection against intolerable anxiety levels and maintenance of an adequate self-concept. The alternate viewpoint defines defensive processes as antithetical to growth and regards the optimally functioning person as defense-free and open to experience. The author examines the implications of these theoretical models for counselling in relation to the following issues: ( 1 ) the openness of the counsellor in the counselling relationship, (2) a view of openness as a form of defense, and (3) dealing with defenses as part of the therapeutic process.
Maximum delay variation temperature-aware standard cell design

Standard cell design suffers from temperature-induced delay uncertainty. In this paper we propose two methodologies to cope with this issue before the logic synthesis step without modifying the standard flow. Both methodologies are based on the study of the cell maximum delay sensitivity to temperature variations to select the cells of the library to be used for the synthesis. We provide icyflex2 CSEM processor synthesis to demonstrate the delay variability reduction obtained.
Age and Sex as Determinants of Mortality After Hip Fracture: 3,895 Patients Followed for 2.5–18.5 Years

Summary: Between 1970 and 1985, a total of 3,895 persons 5=40 years of age were treated for hip fracture in a Danish municipality. The female:male ratio was 2.7. The cumulative survival was estimated and compared with that of the age- and sex-matched general population. The analysis showed that (a) the mortality was increased compared with the expected mortality, especially during the first year (19% for women, 25% for men), but a statistically significant excess mortality could be demonstrated up to 10 years after a hip fracture; (b) the mortality increased with age, even after adjustment for the expected higher mortality of the elderly; and (c) the mortality was higher for men than for women, even after adjustment for the expected higher mortality of males. This difference was already present after the first 2 weeks among patients 3*70 years of age
Efficacy and safety of sitagliptin monotherapy compared with voglibose in Japanese patients with type 2 diabetes: a randomized, double‐blind trial

Objective: To compare the efficacy and safety of sitagliptin (a dipeptidyl peptidase‐4 inhibitor) and voglibose (an α‐glucosidase inhibitor) monotherapy in Japanese patients with type 2 diabetes who have inadequate glycaemic control (HbA1c ≥6.5% and <10.0%) on diet and exercise.
Use of hTERT and HPV E6/E7 mRNA RT-qPCR TaqMan assays in combination for diagnosing high-grade cervical lesions and malignant tumors.

OBJECTIVES Human papillomavirus (HPV) is a major cause of cervical cancer, which is the second most common cancer in women. HPV E6 initiates degradation of cellular tumor suppressor protein p53, induces human telomerase reverse transcriptase (hTERT) activity, and then leads to progressive cervical carcinogenesis. METHODS In this study, the CervicGen HPV RT-qDX assay (Optipharm, Osong, Republic of Korea), which detects 16 HPV high-risk subtypes (HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, and 69), and the CervicGen hTERT RT-qDX assay (Optipharm) were evaluated using 545 ThinPrep (Hologic, Bedford, MA) Papanicolaou samples. RESULTS The positivity for the HPV E6/E7 messenger RNA (mRNA) assay was 94.4%, 95.2%, 82.4%, 46.5%, 25.0%, and 1.1% in squamous cell carcinomas, high-grade squamous intraepithelial lesions (HSILs), atypical squamous cells--cannot exclude HSIL, low-grade squamous intraepithelial lesions, atypical squamous cells of undetermined significance, and normal cytology samples, respectively. Five cervical intraepithelial neoplasia grade 2+ samples were not detected by the HPV E6/E7 mRNA assay, but they exhibited positive signals in the hTERT mRNA assay. Notably, the hTERT mRNA expression level was increased in high-grade cervical lesions but was very low in all 288 normal samples. CONCLUSIONS These data suggest that the combination of HPV E6/E7 and hTERT mRNA expression levels could be used in a complementary manner in diagnosing high-grade cervical lesions and malignant tumors and might be useful as a predictive marker in monitoring low-grade cervical lesions.
Differential Response of Retinoic Acid Pretreated Human Synovial Sarcoma Cell Line to Anticancer Drugs

The response of tumorigenic human synovial sarcoma (HSS) cell line to 10–5M optimum concentration of retinoic acid (RA) included changes in morphology, growth rate, suppression of anchorage-independent growth, induction of high alkaline phosphatase activity and excessive secretion of a 68 kDA glycoprotein of unknown function. HSS cells pretreated with 10–5M RA exhibited differential response to 3 potent anticancer drugs, namely cisplatin, vincristine and adriamycin. Sensitivity of the cells to cisplatin was found to be considerably enhanced after exposure to retinoic acid.
System design for autonomous table tennis ball collecting robot

This paper presents design methodologies and an implementation of autonomous table tennis ball collecting robot. The robot is designed with three major emphases to collect balls effectively in a real table tennis court: ball detection, navigation, and ball collection. For ball detection, a combination of blob detection and cascade classifier was utilized. The robot generates an optimal path toward detected balls using A∗ graph search algorithm and follows the path based on a mecanum-wheeled platform. The detected balls are collected using a suction motor and a 2-DOF active nozzle. The integrated system successfully demonstrates the given task in a real table tennis court.
Availability of diagnostic and treatment services for acute stroke in frontier counties in Montana and Northern Wyoming.

CONTEXT Rapid diagnosis and treatment of ischemic stroke can lead to improved patient outcomes. Hospitals in rural and frontier counties, however, face unique challenges in providing diagnostic and treatment services for acute stroke. PURPOSE The aim of this study was to assess the availability of key diagnostic technology and programs for acute stroke evaluation and treatment in Montana and northern Wyoming. METHODS In 2004, hospital medical directors or their designees were mailed a survey about the availability of diagnostic technology, programs, and personnel for acute stroke care. FINDINGS Fifty-eight of 67 (87%) hospitals responded to the survey. Seventy-nine percent (46/58) of responding hospitals were located in frontier counties, with an average bed size of 18 (11 SD). Of the hospitals in frontier counties, 44% reported emergency medical services prehospital stroke identification programs, 39% had 24-hour computed tomography capability, 44% had an emergency department stroke protocol, and 61% had a recombinant tissue plasminogen activator protocol. Thirty percent of hospitals in frontier counties reported that they met 6-10 of the criteria established by the Brain Attack Coalition to improve acute stroke care compared to 67% of hospitals in the nonfrontier counties. CONCLUSION A stroke network model could enhance care and improve outcomes for stroke victims in frontier counties.
What can entertainment theory say about perceptions of classic versus popular films

The purpose of this study is to examine individuals’ perceptions of classicness in film experiences. To this end, the paper begins by providing general anecdotal and professional definitions of classicness, and by pointing out the limited explication found in previous academic literature in entertainment. I discuss distinctions between enjoyment and appreciation from previous literature in media psychology. Following this, a study is presented by applying a measure of enjoyment and appreciation adapted from Oliver and Bartsch’s scale (2010) to an online questionnaire in order to understand individuals’ film experiences with both popular (high grossing) and classic (high rating) films. Results indicate that perceptions of classicness are highly associated with appreciation, but unrelated to enjoyment. Additionally, results also provide a negative relation between appreciation and the release-year as well as budget. Discussion focuses on the study’s empirical definition of classicness, as well as the study’s extension of previous research examining the relationship between film popularity, budget, and audience perceptions (Grizzard, Lewis, Lee, & Eden, 2011).