Miracle-dz/UniFAR-FTUs huggingface dataset:
P2X7 Receptors Mediate ATP Release and Amplification of Astrocytic Intercellular Ca2+ Signaling

Modulation of synaptic transmission and brain microcirculation are new roles ascribed to astrocytes in CNS function. A mechanism by which astrocytes modify neuronal activity in the healthy brain depends on fluctuations of cytosolic Ca2+ levels, which regulate the release of “gliotransmitters” via an exocytic pathway. Under pathological conditions, however, the participation of other pathways, including connexin hemichannels and the pore-forming P2X7R, have been proposed but remain controversial. Through the use of genetically modified 1321N1 human astrocytoma cells and of spinal cord astrocytes derived from neonatal Cx43- and P2X7R-null mice, we provide strong evidence that P2X7Rs, but not Cx43 hemichannels, are sites of ATP release that promote the amplification of Ca2+ signal transmission within the astrocytic network after exposure to low divalent cation solution. Moreover, our results showing that gap junction channel blockers (heptanol, octanol, carbenoxolone, flufenamic acid, and mefloquine) are antagonists of the P2X7R indicate the inadequacy of using these compounds as evidence for the participation of connexin hemichannels as sites of gliotransmitter release.
Research on Listed Firms' Financial Distress Pre-Warning Based on a Longitudinal Data Envelopment Analysis

As listed firms' financial distress is not always occasional, it is necessary to consider dynamic change of the firms' financial condition when the firms' financial distress is pre-warned. In this paper, a longitudinal data envelopment analysis is employed to consider dynamically the listed firms' financial condition, and every listed firm in various periods is viewed as various decision making unit. Firstly, make certain a window which means one period. Secondly, evaluate the decision making units in every window with data envelopment analysis and make an estimate of dynamic change of every decision making unit's financial condition to pre-warn decision making units' financial distress. And then an empirical case shows the feasibility and validity of the method that is put forward in this paper.
Interaction of macrophages with apoptotic cells inhibits transdifferentiation and invasion of lung fibroblasts

The invasion of activated fibroblasts is a key mechanism of tissue fibrosis pathology. The recognition and uptake of apoptotic cells can induce the anti-fibrogenic programming of macrophages. We demonstrate that after interacting with apoptotic cells, macrophages secrete bioactive molecules that antagonize TGF-β1-induced increases in myofibroblast (fibroproliferative) phenotypic markers and reduce the enhanced invasive capacity of TGF-β1- or EGF-treated mouse lung fibroblasts (MLg). Furthermore, numerous treatment strategies prevented the anti-fibrotic effects of conditioned media, including transfection of macrophages with COX-2 or RhoA siRNAs or treatment of MLg cells with receptor antagonists for prostaglandin E2 (PGE2), PGD2, or hepatocyte growth factor (HGF). Additionally, administration of apoptotic cells in vivo inhibited the bleomycin-mediated invasive capacity of primary fibroblasts, as well as adhesion and extracellular matrix protein mRNA expression. These data suggest that the anti-fibrogenic programming of macrophages by apoptotic cells can be used as a novel tool to control the progressive fibrotic reaction.
Mining Maximal Frequent Itemsets with Frequent Pattern List

Mining frequent itemsets is a major aspect of association rule research. However, the mining of the complete of frequent itemsets will lead to a huge number of itemsets. Fortunately, this problem can be reduced to the mining of maximal frequent itemsets. In this paper, we adopt frequent pattern list (FPL) and bit string technique, propose a novel algorithm for mining maximal frequent itemsets based on frequent pattern list (FPLMFI-Mining). It conducts various operations on FPL according to the frequency of frequent items. Moreover, it utilizes bit string and-operation to test maximal frequent itemsets. This algorithm can be scaled up to very large databases by parallel projection and compress technique.
and Parental Representations

Relationships between attachment styles and the content and structure of mental representations of parents were investigated. Undergraduates completed 3- and 4-category measures of attachment style and wrote descriptions of their parents. Securely attached participants' parental representations were characterized by differentiation, elaboration, benevolence, and nonpunitiveness. Representations by dismissing participants were characterized by less differentiation and more punitiveness and malevolence. Fearful participants also described their parents as relatively punitive and malevolent, but their representations were well differentiated and conceptually complex. Anxious-ambivalent participants described their parents ambivalently as both punitive and benevolent. A basic postulate of both attachment theory (e.g., Ainsworth, 1969; Bowlby, 1969/1982, 1973, 1980; Bretherton, 1985) and object relations theory (e.g., Blatt, 1974, 1995; Fairbairn, 1952; Kernberg, 1975; Winnicott, 1960) is that mental representations of self and others emerge from early relationships with caregivers and then act as heuristic guides for subsequent close relationships. Attachment theory and object relations theory both posit that the structure (e.g., coherence or integration) and the content (e.g., the belief that relationship partners are generally benevolent) of these cognitive-affective schemas influence expectations and feelings as well as the general patterns of behavior that characterize people's interpersonal relationships (Diamond & Blatt, 1994; Slade & Aber, 1992). To date, however, researchers who study adult attachment have not generally explored the ideas and measures created by object relations theorists. The purpose of the present research is to explore the content and structure of representations of parents associated with different adult attachment styles.
Epipodophyllotoxins, alkylating agents, and radiation and risk of secondary leukaemia after childhood cancer.

OBJECTIVE--To investigate the incidence and aetiology of secondary leukaemia after childhood cancer in Britain. DESIGN--Cohort study and a case-control study. SETTING--Britain and population based National Register of Childhood Tumours. SUBJECTS--Cohort of 16,422 one year survivors of childhood cancer diagnosed in Britain between 1962 and 1983, among whom 22 secondary leukaemias were observed. A case-control study of 26 secondary leukaemias observed among survivors of childhood cancer diagnosed in Britain between 1940 and 1983; 96 controls were selected matched for sex, type of first cancer, age at first cancer, and interval to diagnosis of secondary leukaemia. MAIN OUTCOME MEASURES--Dose of radiation averaged over patients' active bone marrow and total accumulated dose of epipodophyllotoxins, alkylating agents, vinca alkaloids, antimetabolites, and antibiotics (mg/m2) given for the original cancer. RESULTS--Cumulative risk of secondary leukaemia within the cohort did not exceed 0.5% over the initial five years beyond one year survival, except that after non-Hodgkin's lymphomas 1.4% of patients developed secondary leukaemia. Corresponding figure for patients treated for non-Hodgkin's lymphomas in the early 1980s was 4%. The relative risk of secondary leukaemia increased significantly with exposure to epipodophyllotoxins and dose of radiation averaged over patients' active bone marrow. Ten patients developed leukaemia after having an epipodophyllotoxin-teniposide in nine cases, etoposide in one. Chromosomal translocations involving 11q23 were observed relating to two secondary leukaemias from a total of six for which there were successful cytogenetic studies after administration of an epipodophyllotoxin. CONCLUSIONS--Epipodophyllotoxins acting alone or together with alkylating agents or radiation seem to be involved in secondary leukaemia after childhood cancer.
Patterns of reactivity with anti‐glycolipid antibodies in human primary brain tumors

Antibodies against carbohydrates of three glycolipids were used to determine patterns of immunohistochemical reactivity of histologically identifiable cell subpopulations in 101 human primary brain tumors. For all tumor types fibrillary cells, polar cells, and gemistocytes (commonly seen in astrocytomas and ependymomas) stained more frequently for galactosylcerebroside with mAbO1 than small tumor cells and macrophages. Frequency of staining for sulfatide with mAbO4 was fibrillary > polar > small cells = macrophages. Gemistocytes stained more frequently with mAbO4 than polar cells in all tumors except low grade astrocytomas. These data indicate that tumors classified on histological grounds as astrocytic are often stained with antibodies that recognize oligodendrocytes and their progenitors. Thus, anti‐glycolipid antibodies used in the study of developmental lineage may offer useful tools for classification of human brain tumors. Staining of fibrillary cells, polar cells, and gemistocytes for paragloboside directly with mAb F1H11 was much less common than with mAbO1, but this increased by pretreatment of the tissues with neuraminidase (F1H11 + N). Of particular note was the finding that small tumor cells frequently stained with F1H11 + N. Evidence that these were not macrophages was obtained using double immunostaining with F1H11 + N and anti‐macrophage antibodies. In astrocytomas the frequency of small tumor cells immunostained with F1H11 + N was high grade > anaplastic > low grade, demonstrating a correlation of this tumor cell population with more F1H11 + N may be of value in identifying small, ana‐plastic tumor cells, especially in small biopsies or tissue taken adjacent to the main tumor mass. Copyright © 1994 Wiley‐Liss, Inc.
Energy efficiency of small cell backhaul networks based on Gauss-Markov mobile models

To satisfy the recent growth of mobile data usage, small cells are recommended to deploy into conventional cellular networks. However, the massive backhaul traffic is a troublesome problem for small cell networks, especial in wireless backhaul transmission links. In this study, backhaul traffic models are first presented considering the Gauss–Markov mobile models of mobile stations in small cell networks. Furthermore, an energy efficiency model of small cell backhaul networks with Gauss–Markov mobile models has been proposed. Numerical results indicate that the energy efficiency of small cell backhaul networks can be optimised by trade-off the number and radius of small cells in cellular networks.
Nigella sativa L. as an alternative antibiotic feed supplement and effect on growth performance in weanling pigs.

BACKGROUND Nigella sativa L. (NS) is a plant containing bioactive constituents such as thymoquinone. Extracts of NS improve performance and reduce enteropathogen colonization in poultry and small ruminants, but studies with swine are lacking. In two different studies oral administration of NS extracts at doses equivalent to 0, 1.5 and 4.5 g kg-1 diet was assessed on piglet performance and intestinal carriage of wildtype Escherichia coli and Campylobacter, and Salmonella Typhimurium. RESULTS Wildtype E. coli populations in the jejunal and rectal content collected 9 days after treatment began were decreased (P ≤ 0.05). Populations recovered from pigs treated with extract at 1.5 and 4.5 g kg-1 diet were 0.72-1.31 log10 units lower than the controls (ranging from 6.05 to 6.61 log10 CFU g-1 ). Wildtype Campylobacter and Salmonella Typhimurium were unaffected by NS treatment. Feed efficiency over the 9 days improved linearly (P < 0.05) from 3.88 with 0 NS-treated pigs to 1.47 and 1.41 with pigs treated with NS at 1.5 and 4.5 g kg-1 diet, respectively, possibly due to high glutamine/glutamic acid content of the NS extract. CONCLUSION NS supplementation of weanling pigs improved feed efficiency and helped control intestinal E. coli during this vulnerable production phase. © 2017 Society of Chemical Industry.
On the Discourse of Advertising Slogans: A Study of Advertising Language

Art is an integral part of human existence and t he question about art which has always perplexed human minds is what can be included under the gamut of art? As times progressed, this question became all the more persuasive followed by the birth of certain activities, such as advertisements, often deemed creative but not always considered artistic. This debate over the artistic or the non-artistic nature of advertisements is based on the debate of banality of art and the conflict between high and low art. Certainly this debate regarding the artistic or non-artistic status of advertisements is divided between two schools, each taking a side either in favor of the artistic status of advertisement or the opposite. There have been many theories and techniques devised to determine the status of advertisements. One of the techniques or devices that can be used particularly for ads abundant with texts is language and its usages as it is a determining factor from various perspectives. This element of language hence can be used to assess the debate regarding the status of ads as art or non-art. Thus, the objective of this paper is to look into those elements of language which may render ‘art’ or ‘non-art’ status to advertisements, with the advertising slogans being the subject of interest here. nt-size: 10.0pt;font-weight:normal;mso-bidi-font-weight:bold'>In this paper we analyze news internet web page for marketing corporations so that we can discover responsiveness of consumer uses these on-line news gateway. Due to the fact online media is growing daily the data is regularly and dynamically generated so we need some sort of mechanism to analyze terra bytes (TB) of data. This study will accomplish using big facts analysis.
The complete chloroplast genome sequence of Euonymus japonicus (Celastraceae)

Abstract The complete chloroplast (cp) genome sequence of the Euonymus japonicus, the first sequenced of the genus Euonymus, was reported in this study. The total length was 157 637 bp, containing a pair of 26 678 bp inverted repeat region (IR), which were separated by small single copy (SSC) region and large single copy (LSC) region of 18 340 bp and 85 941 bp, respectively. This genome contains 107 unique genes, including 74 coding genes, four rRNA genes, and 29 tRNA genes. Seventeen genes contain intron of E. japonicus, of which three genes (clpP, ycf3, and rps12) include two introns. The maximum likelihood (ML) phylogenetic analysis revealed that E. japonicus was closely related to Manihot and Populus.
p16INK4a, Cytokeratin 7, and Ki-67 as Potential Markers for Low-Grade Cervical Intraepithelial Neoplasia Progression

Objective The aim of this study was to evaluate p16INK4a, cytokeratin 7 (CK7), and Ki-67 immunoexpressions in low-grade squamous intraepithelial lesion (LSIL), looking for differences among cases that progress to high-grade squamous intraepithelial lesion, maintain LSIL, or regress. Materials and Methods Sixty-six LSIL biopsies were studied. In the follow-up, a second biopsy showed 28.7% regression, 37.9% LSIL, and 33.4% progressed to high-grade squamous intraepithelial lesion. Immunostaining for these markers were performed in the first biopsy. A qualitative evaluation method was used, as well as histomorphometry, using ImageJ software. Pearson &khgr;2, Mann-Whitney, Kruskal-Wallis, and Fisher tests were used to compare the groups (P ⩽ .05). A cutoff point was assessed through receiver operating characteristic curve positive cell ratio, for each marker, as progression predictors. Results The mean age of patients with and without progression was 33 and 27 years (P = .006), respectively. The qualitative evaluation indicated a tendency of progression, but without statistical significance. However, through histomorphometry, the receiver operating characteristic curve analysis showed cutoff points of 0.396, 0.345, and 0.026 for p16INK4a, CK7, and Ki-67 ratios, respectively, as predictors of progression (P = .003, .03, and .002, respectively). In a logistic regression analysis, p16INK4a, CK7, and Ki-67 positive cell ratio showed a significant correlation with progression (P = .036, .012, and .006, respectively). Conclusions p16INK4a, CK7, and Ki-67 may represent useful biomarkers that can identify LSIL lesions that need particular attention.
Can We Detect Chronic Pancreatitis With Low Serum Pancreatic Enzyme Levels?

Objectives The aims of this study were to evaluate whether serum pancreatic enzyme levels could be used to aid screening for chronic pancreatitis (CP). Methods 170 healthy volunteers were screened and prospectively enrolled in the control group. 150 patients who were diagnosed with calcific CP were enrolled in the patient group by retrospective review. Serum amylase and lipase levels were compared between the 2 groups. Results The mean values ± SD of the control group were compared with those of the patient group for serum amylase level (48.1 ± 13.2 vs 34.8 ± 17.2 U/L, P < 0.001) and serum lipase level (26.4 ± 11.3 vs 16.3 ± 11.2 U/L, P < 0.001). On the receiver operating characteristic curve analysis for amylase level, area under the curve was 0.740 (95% confidence interval), and sensitivity and specificity were 38.7% and 94.1%, respectively, with a cutoff value of 27.5 U/L. On the receiver operating characteristic curve analysis for lipase level, area under the curve was 0.748 (95% confidence interval), and sensitivity and specificity were 33.3% and 95.9%, respectively, with a cutoff value of 10.5 U/L. Conclusions Our results suggest that low serum pancreatic enzyme levels can be used to aid in detection of CP.
Cangrelor in Older Patients Undergoing Percutaneous Coronary Intervention: Findings From CHAMPION PHOENIX

Background— Older patients treated with percutaneous coronary intervention are at increased risk of periprocedural events. Methods and Results— CHAMPION (cangrelor versus standard therapy to achieve optimal management of platelet inhibition) PHOENIX randomized 11 145 patients to cangrelor or clopidogrel. We sought to determine the outcomes in the prespecified subgroup of patients ≥75 years old (n=2010; 18%). Cangrelor resulted in directionally consistent effects on the primary end point (death, myocardial infarction, ischemia-driven revascularization, or stent thrombosis) in patients ≥75 years old (odds ratio [OR], 0.71; 95% confidence interval [CI], 0.50–1.02) and in those <75 years old (OR, 0.81; 95% CI, 0.67–0.98; P [interaction]=0.55). Age ≥75 years was an independent predictor of GUSTO (Global Use of Strategies to Open Occluded Coronary Arteries) moderate/severe bleeding (1.0% versus 0.3%; adjusted OR, 2.94; 95% CI, 1.28–6.77; P=0.01) when compared with patients <75 years old. There was no significant difference in GUSTO moderate/severe bleeding with cangrelor versus clopidogrel (1.1% versus 1.0%; OR, 1.07; 95% CI 0.45–2.53) in patients ≥75 years old or in those <75 years old (0.4% versus 0.2%; OR, 2.24; 95% CI, 1.02–4.93; P [interaction]=0.21). For the net composite end point of death, myocardial infarction, ischemia-driven revascularization, or stent thrombosis plus GUSTO moderate/severe bleeding, the OR for cangrelor in those ≥75 years old was 0.75 (6.4% versus 8.3%; 95% CI, 0.54–1.05; P=0.09). The effects were similar in those <75 years old (4.9% versus 5.8%; OR, 0.85; 95% CI, 0.70–1.02; P=0.08; P [interaction]=0.53). Conclusions— Patients ≥75 years old have an overall ≈3-fold increased odds of moderate/severe bleeding. Cangrelor, when compared with clopidogrel, provides similar efficacy and in patients ≥75 years old as in those <75 years old but does not increase the risk of major bleeding. Clinical Trial Registration— URL: https://www.clinicaltrials. gov. Unique identifier: NCT01156571.
Inflammatory biomarkers and radiologic measurements in never-smokers with COPD: A cross-sectional study from the CODA cohort

Various biomarkers have emerged as potential surrogates to represent various subgroups of chronic obstructive pulmonary disease (COPD), which manifest with different phenotypes. However, the biomarkers representing never-smokers with COPD have not yet been well elucidated. The aim of this study was to evaluate the associations of certain serum and radiological biomarkers with the presence of COPD in never-smokers. To explore the associations of serum and radiological biomarkers with the presence of COPD in never-smokers, we conducted a cross-sectional patient cohort study composed of never-smokers from the COPD in Dusty Areas (CODA) cohort, consisting of subjects living in dusty areas near cement plants in South Korea. Of the 131 never-smokers in the cohort, 77 (58.8%) had COPD. There were no significant differences in the number of subjects with high levels of inflammatory biomarkers (>90th percentile of never-smokers without COPD), including white blood cell count, total bilirubin, interleukin (IL)-6, IL-8, and C-reactive protein, or radiologic measurements (including emphysema index and mean wall area percentage) between never-smokers with COPD and those without COPD. However, the number of subjects with high uric acid was significantly higher in never-smokers with COPD than never-smokers without COPD (31.2% (24/77) vs. 11.1% (6/54); p = 0.013). In addition, multivariate analysis revealed that high uric acid was significantly associated with the presence of COPD in never-smokers (adjusted relative risk: 1.63; 95% confidence interval: 1.21, 2.18; p = 0.001). Our study suggests that high serum levels of uric acid might be a potential biomarker for assessing the presence of COPD in never-smokers.
Dorsal medial prefrontal cortex (MPFC) circuitry in rodent models of cocaine use: implications for drug addiction therapies

Although the importance of the medial prefrontal cortex (MPFC) in cocaine addiction is well established, its precise contribution to cocaine seeking, taking and relapse remains incompletely understood. In particular, across two different models of cocaine self‐administration, pharmacological or optogenetic activation of the dorsal MPFC has been reported to sometimes promote and sometimes inhibit cocaine seeking. We highlight important methodological differences between the two experimental paradigms and propose a framework to potentially reconcile the apparent discrepancy. We also draw parallels between these pre‐clinical models of cocaine self‐administration and human neuro‐imaging studies in cocaine users, and argue that both lines of evidence point to dynamic interactions between cue‐reactivity processes and control processes within the dorsal MPFC circuitry. From a translational perspective, these findings underscore the importance of interventions and therapeutics targeting not just a brain region, but a specific computational process within that brain region, and may have implications for the design and implementation of more effective treatments for human cocaine addiction.