Miracle-dz/UniFAR-FTUs huggingface dataset:
Design and Implementation of Taizhou Integrated Prostate Screening

A community-based prostate cancer screening program was conducted to assess the morbidity and associated factors for prostate cancer among the subpopulation of men aged ≥50 years in Taizhou, China. Taizhou Integrated Prostate Screening (TIPS) is a large, observational, population-based study of prostate cancer screening data based on serum prostate-specific antigen (PSA) concentrations. A pilot census of all male residents aged 50 years or older was conducted in Luqiao District, one of the field sites of the TIPS cohort in the city of Taizhou, Zhejiang. The interviewer-administered questionnaire evaluated demographic characteristics and environmental exposure factors. A total of 1,806 out of 3,516 participants completed the questionnaire. The overall prevalence of PSA ≥4 ng/mL was 11.5%, and included participants at low risk (9.2%), moderate risk (1.7%), and high risk (0.6%). Participants aged 60–69, 70–79, and ≥80 years had a 2.7-fold, 4.2-fold, and 6.5-fold higher risk of elevated PSA, respectively, in comparison with those aged 50 to 59 years (p < .001). Eighteen patients were diagnosed with prostate cancer, of whom 11 (61.1%) underwent radical surgery. This community-based PSA screening program indicated the results for early detection of prostate cancer among men aged ≥50 years. Early screening and appropriate clinical therapy for the management of prostate cancer are essential in this subpopulation.
Super-Acceleration from Massless, Minimally Coupled $\phi^4$

We derive a simple form for the propagator of a massless, minimally coupled scalar in a locally de Sitter geometry of arbitrary spacetime dimension. We then employ it to compute the fully renormalized stress tensor at one- and two-loop orders for a massless, minimally coupled 4 theory which is released in Bunch? Davies vacuum at t = 0 in co-moving coordinates. In this system, the uncertainty principle elevates the scalar above the minimum of its potential, resulting in a phase of super-acceleration. With the non-derivative self-interaction the scalar's breaking of de Sitter invariance becomes observable. It is also worth noting that the weak-energy condition is violated on cosmological scales. An interesting subsidiary result is that cancelling overlapping divergences in the stress tensor requires a conformal counterterm which has no effect on purely scalar diagrams.
Interaction of heavy metals in Drosophila melanogaster larvae: Fourier transform infrared spectroscopy and single-cell electrophoresis study

Abstract The present study evaluates the Murraya Koenigii (CuLE) and Tinospora Crispa (TiSE) antimutagenic effect and the impact of industrial soil and solid waste leachate on Drosophila larvae. Larvae were exposed to leachate prepared at different pH (7, 4.93, 2.88) and treated with TiSE and CuLE at different concentration (4 g/L and 6 g/L) mixed with standard Drosophila medium. Emphasis was given to the binding interaction of heavy metals with proteins in Drosophila. The change in structure and molecular composition in Drosophila by leachate containing heavy metals induced toxicity has been studied by using Fourier transform infrared (FTIR) spectroscopy. Results from the study demonstrated that CuLE/TiSE administration restored the level of oxidative stress as evidenced by an enhanced antioxidant system and a decrease in lipid peroxidation and protein oxidation. The amide I and amide II bands spectral shifting revealed the binding interaction. The shift in the peak of PO2− asymmetric stretching might be due to compositional changes in nucleic acids. Single-cell electrophoresis was performed to detect the DNA damage which also proved to be ameliorated by administration of CuLE/TiSE. The result concludes that CuLE/TiSE may have great potential in the protection of Drosophila larvae from leachate induced oxidative stress through antioxidant and antimutagenic mechanisms this might help to cope with environmental toxicants. Communicated by Ramaswamy H. Sarma
Illness perception and quality of life in patients with migraine and tension-type headache

ABSTRACT Introduction Migraine and tension-type headache (TTH) are important health problems because cause loss of workforce, affect quality of life and are frequently associated with anxiety and depression. Illness perception is defined as a cognitive aspect of illness. The aim of this study is to determinethe relationship of migraine and TTH with quality of life, illness perception, anxiety and depression. Materials and Methods Demographic information and headache characteristics of 160 patients (80 migraine, 80 TTH) who has applied to our hospital’s neurology outpatient clinics were recorded. Hospital anxiety depression scale, illness perception questionnaire and quality of life short form-36 (SF-36) were applied to these patients. Results Headache severity and duration were higher in migraine patients. Migraine sufferers believed that their illness would last longer and the results would be worse. Negative emotional representations were more common in TTH patients. Understanding of the disease was higher in younger and those with higher levels of education. Social functionality and bodily pain scores were worse than those of TTH patients. Headache severity and duration were higher in women. Anxiety and depression were associated with headache frequency, duration, and severity. It was determined that the severity, duration and frequency of headache also affected the quality of life. Conclusion Informing patients in detail about their diseases and increasing their education level can contribute to the improvement of headache representations. In addition, screening and treatment of anxiety and depression may be other interventions that can improve patients’ adherence to treatment and quality of life.
A Fresh View of Henize 2-10 with VLT NAOS-CONICA

We present high-resolution observations of Henize 2-10 in Ks (2.2 μm), L' (3.8 μm), and M' (4.8 μm) bands. These allow us, for the first time, to track accurately the structures at the heart of the galaxy from the optical to the radio. All radio knots previously observed can now be associated with L'- and Ks-emitting regions. This implies a revision of their physical nature. Instead of highly extinguished ultradense H II regions, we propose that two of the five radio knots are either supernova remnants or normal H II regions, while the remaining three are bona fide ultradense H II regions, although less obscured than previously thought.
g factor of the bound electron and muon

Quantum electrodynamics (QED) corrections to the g factor of the bound electron and muon in the hydrogenlike atom are discussed. An approach that allows one to express the relativistic g factor of spin-1/2 particle in terms of the binding energy is applied to the calculation of the corrections to the g factor due to the finite nuclear size, including the vacuum polarization radiative correction. The contribution of the light-by-light diagram to the g factor of the bound electron and muon is calculated. For light one-electron ions, which are important for the experiment, this contribution has, so far, not been known.PACS Nos.: 31.15. Pf, 31.30. Jv, 32.10. Hq
PlagueKD: a knowledge graph–based plague knowledge database

Abstract Plague has been confirmed as an extremely horrific international quarantine infectious disease attributed to Yersinia pestis. It has an extraordinarily high lethal rate that poses a serious hazard to human and animal lives. With the deepening of research, there has been a considerable amount of literature related to the plague that has never been systematically integrated. Indeed, it makes researchers time-consuming and laborious when they conduct some investigation. Accordingly, integrating and excavating plague-related knowledge from considerable literature takes on a critical significance. Moreover, a comprehensive plague knowledge base should be urgently built. To solve the above issues, the plague knowledge base is built for the first time. A database is built from the literature mining based on knowledge graph, which is capable of storing, retrieving, managing and accessing data. First, 5388 plague-related abstracts that were obtained automatically from PubMed are integrated, and plague entity dictionary and ontology knowledge base are constructed by using text mining technology. Second, the scattered plague-related knowledge is correlated through knowledge graph technology. A multifactor correlation knowledge graph centered on plague is formed, which contains 9633 nodes of 33 types (e.g. disease, gene, protein, species, symptom, treatment and geographic location), as well as 9466 association relations (e.g. disease–gene, gene–protein and disease–species). The Neo4j graph database is adopted to store and manage the relational data in the form of triple. Lastly, a plague knowledge base is built, which can successfully manage and visualize a large amount of structured plague-related data. This knowledge base almost provides an integrated and comprehensive plague-related knowledge. It should not only help researchers to better understand the complex pathogenesis and potential therapeutic approaches of plague but also take on a key significance to reference for exploring potential action mechanisms of corresponding drug candidates and the development of vaccine in the future. Furthermore, it is of great significance to promote the field of plague research. Researchers are enabled to acquire data more easily for more effective research. Database URL: http://39.104. 28.169:18095/
Optical properties of p-type Al and N co-doped ZnO films

Effect of Al-N codoping ratio on the conducting and optical properties of ZnO films deposited by helicon wave plasma assisted radio frequency magnetron sputtering under various N2 gas flow is investigated. Hall measurements show that p-type ZnO thin films have been achieved with proper N2 flow rate. X-ray diffraction patterns indicate that all the films are highly c-axis oriented. Room temperature photoluminescence spectra show a strong near-band-edge emission. With increasing N doping, the intensity of the emission behaves an increased and then decreased trend while the full width at half maximum is narrowed and then widened. In addition, photoluminescence spectrum at 77 K in the p-type ZnO film with the highest hole concentration show a much stronger peak near 3.32 eV (due to N related neutral acceptor bound excitons), than at 3.36 eV (neutral donor bound excitons), and the acceptor energy level is estimated to be 186 meV.
Characterization of a novel androgen receptor gene variant identified in an Iranian family with complete androgen insensitivity syndrome (CAIS): a molecular dynamics simulation study

Abstract Androgen insensitivity syndrome (AIS) is a common form of 46, XY disorder in sex development disease (DSD). It is due to the androgen receptor (AR) gene mutations and includes clinical subgroups of complete AIS (CAIS) and partial AIS (PAIS), along with a vast area of clinical heterogeneity of completely normal female external genitalia to male infertility. In this study, the Whole Exome Sequencing (WES) was utilized to detect the cause of DSD in a consanguineous Iranian family with two female patients with normal external genitalia and 46, XY karyotype. Sanger sequencing was applied to validate the candidate variant. Next, we predicted the structural alteration induced by the variant on AR protein using bioinformatics analysis such as molecular dynamic (MD) and molecular docking simulations. WES results identified a novel hemizygous p.L763V variant in the AR gene in the proband that was compatible with the X-linked recessive pattern of inheritance. Bioinformatics studies confirmed the loss of AR function. Based on the American College of Medical Genetics and Genomics (ACMG) guidelines, it was categorized as pathogenic. This study broadens the AR mutation spectrum and introduces the novel p.L763V missense pathogenic variant leading to AR failure to bind to its ligand, and the resulting CAIS clinical subgroup. This study presents a prosperous application of WES and bioinformatics analysis to recognize the underlying cause of DSD in Iran, necessary for its clinical/psychological management. Communicated by Ramaswamy H. Sarma
Photoluminescence properties and exciton dynamics in monolayer WSe2

In this work, comprehensive temperature and excitation power dependent photoluminescence and time-resolved photoluminescence studies are carried out on monolayer WSe2 to reveal its properties of exciton emissions and related excitonic dynamics. Competitions between the localized and delocalized exciton emissions, as well as the exciton and trion emissions are observed, respectively. These competitions are suggested to be responsible for the abnormal temperature and excitation intensity dependent photoluminescence properties. The radiative lifetimes of both excitons and trions exhibit linear dependence on temperature within the temperature regime below 260 K, providing further evidence for two-dimensional nature of monolayer material.
Low c-Kit expression identifies primitive, therapy-resistant CML stem cells

Despite the efficacy of tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML), malignant long-term hematopoietic stem cells (LT-HSCs) persist as a source of relapse. However, LT-HSCs are heterogenous and the most primitive, drug-resistant LT-HSC subpopulations are not well characterized. In normal hematopoiesis, self-renewal and long-term reconstitution capacity are enriched within LT-HSCs with low c-Kit expression (c-KITlo). Here, using a transgenic CML mouse model, we found that long-term engraftment and leukemogenic capacity were restricted to c-KITlo CML LT-HSCs. CML LT-HSCs demonstrated enhanced differentiation with expansion of mature progeny following exposure to the c-KIT ligand, stem cell factor (SCF). Conversely, SCF deletion led to depletion of normal LT-HSCs but increase in c-KITlo and total CML LT-HSCs with reduced generation of mature myeloid cells. CML c-KITlo LT-HSCs showed reduced cell cycling and expressed enhanced quiescence and inflammatory gene signatures. SCF administration led to enhanced depletion of CML primitive progenitors but not LT-HSCs after TKI treatment. Human CML LT-HSCs with low or absent c-KIT expression were markedly enriched after TKI treatment. We conclude that CML LT-HSCs expressing low c-KIT levels are enriched for primitive, quiescent, drug-resistant leukemia-initiating cells and represent a critical target for eliminating disease persistence.
Efficacy and safety of intensive downstaging polypectomy (IDP) for multiple duodenal adenomas in patients with familial adenomatous polyposis: a prospective cohort study

BACKGROUND AND STUDY AIMS Patients with familial adenomatous polyposis (FAP) risk developing multiple duodenal adenomas (MDAs), leading to duodenal cancer and death. We investigated the safety and efficacy of intensive endoscopic intervention for MDAs integrated with new-generation procedures. PATIENT AND METHODS This prospective phase II study, conducted at a tertiary cancer center, enrolled FAP patients with MDAs. We performed intensive endoscopic interventions, including cold snare/forceps polypectomy (CSP/CFP) and underwater endoscopic mucosal resection (UEMR). The primary endpoint was the downstaging of Spigelman stage at 1-year follow-up. RESULTS Totally, 2424 duodenal polyps in 58 patients with FAP underwent interventions, including 2413 CSPs in 57, seven CFPs in one, and four UEMRs in four patients. The major adverse event observed was one grade 3 hyperamylasemia without clinical manifestations. We performed additional UEMR, CSP, and CFP for one, eight, and 21 patients, respectively, during follow-up. Fifty-five patients completed protocol examination; the Spigelman stage was significantly reduced at the 1-year follow-up endoscopy (p<0.001), with downstaging observed in 39 patients (71%). Among the 26 patients with Spigelman stage IV at the initial examination, 23 (88%) showed downstaging. There was no major change in Spigelman stages with a median (range) of 37 (3-56) months' observation after 1-year follow-up esophagogastroduodenoscopy. CONCLUSIONS Intensive endoscopic intervention, including new-generation procedures, showed significant downstaging with acceptable adverse events for MDA in FAP patients, even those with advanced-stage disease. Lesion selection for different resection techniques may be important for suitable and sustainable management of MDA in FAP patients (Trial Reg Num: UMIN000022525).
Olfactory testing as COVID-19 screening in school children; A prospective cross-sectional study

Background Little is known about olfactory changes in pediatric COVID-19. It is possible that children under-report chemosensory changes on questionnaires, similar to reports in adults. Here, we aim to describe COVID-19-related olfactory dysfunction in outpatient children. We hypothesized that children with COVID-19 will demonstrate abnormal olfaction on smell-identification testing at a higher rate than children with negative COVID-19 testing. Methods A prospective cross-sectional study was undertaken from June 2020—June 2021 at a tertiary care pediatric hospital. A consecutive sample of 205 outpatients aged 5–21 years undergoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) PCR testing were approached for this study. Patients with prior olfactory dysfunction were excluded. Participants were given a standard COVID-19 symptom questionnaire, a Smell Identification Test (SIT) and home-odorant-based testing within 2 weeks of COVID-19 testing. Prior to study enrollment, power calculation estimated 42 patients to determine difference in rates of SIT results between groups. Data were summarized with descriptive statistics. Results Fifty-one patients underwent smell identification testing (23 positive (45%) and 28 negative (55%) for COVID-19; mean age 12.7 years; 60% female). 92% of all patients denied subjective change in their sense of smell or taste but only 58.8% were normosmic on testing. There was no difference in screening questionnaires or SIT scores between COVID-19 positive and negative groups. Conclusions Unlike adults, there was no statistical difference in olfactory function between outpatient COVID-19 positive and negative children. Our findings suggest a discrepancy between objective and patient-reported olfactory function in pediatric patients, and poor performance of current screening protocols at detecting pediatric COVID-19.
Bitcoin and S&P500: Co-movements of high-order moments in the time-frequency domain

Interactions between stock and cryptocurrency markets have experienced shifts and changes in their dynamics. In this paper, we study the connection between S&P500 and Bitcoin in higher-order moments, specifically up to the fourth conditional moment, utilizing the time-scale perspective of the wavelet coherence analysis. Using data from 19 August 2011 to 14 January 2022, the results show that the co-movement between Bitcoin and S&P500 is moment-dependent and varies across time and frequency. There is very weak or even non-existent connection between the two markets before 2018. Starting 2018, but mostly 2019 onwards, the interconnections emerge. The co-movements between the volatility of Bitcoin and S&P500 intensified around the COVID-19 outbreak, especially at mid-term scales. For skewness and kurtosis, the co-movement is stronger and more significant at mid- and long-term scales. A partial-wavelet coherence analysis underlines the intermediating role of economic policy uncertainty (EPU) in provoking the Bitcoin-S&P500 nexus. These results reflect the co-movement between US stock and Bitcoin markets beyond the second moment of return distribution and across time scales, suggesting the relevance and importance of considering fat tails and return asymmetry when jointly considering US equity-Bitcoin trading or investments and the policy formulation for the sake of US market stability.
The Formation of a Realistic Disk Galaxy in Λ-dominated Cosmologies

We simulate the formation of a realistic disk galaxy within the hierarchical scenario of structure formation and study its internal properties to the present epoch. We use a set of smoothed particle hydrodynamic (SPH) simulations, with a high dynamical range and force resolution, that include cooling, star formation, supernovae (SNe) feedback and a redshift-dependent UV background. We compare results from a Λ cold dark matter (ΛCDM) simulation to a Λ warm dark matter (ΛWDM) (2 keV) simulation that forms significantly less small-scale structure. We show how high mass and force resolution in both the gas and dark-matter components play an important role in solving the angular momentum catastrophe claimed from previous simulations of galaxy formation within the hierarchical framework. Hence, a large disk forms without the need of strong energy injection, the z = 0 galaxies lie close to the I band Tully-Fisher relation, and the stellar material in the disk component has a final specific angular momentum equal to 40% and 90% of the dark halo in the ΛCDM and ΛWDM models, respectively. If rescaled to the Milky Way, the ΛCDM galaxy has an overabundance of satellites, with a total mass in the stellar halo 40% of that in the bulge+disk system. The ΛWDM galaxy has a drastically reduced satellite population and a negligible stellar spheroidal component. Encounters with satellites play only a minor role in disturbing the disk. Satellites possess a variety of star formation histories linked to mergers and pericentric passages along their orbit around the primary galaxy. In both cosmologies, the galactic halo retains most of the baryons accreted and builds up a hot gas phase with a substantial X-ray emission. Therefore, while we have been successful in creating a realistic stellar disk in a massive galaxy within the ΛCDM scenario, energy injection emerges as necessary ingredient to reduce the baryon fraction in galactic halos, independent of the cosmology adopted.
Trajectories of Preventive Health Care Utilization Among Older Koreans: The Role of Social Relationships

Background Receiving timely health screening is associated with important public health benefits among older adults. By focusing on the role of social relationships, the present study was aimed at examining longitudinal trajectories of health screening use among older adults in Korea, whose universal health care system provides free-of-charge health screening. Methods A nationally representative sample of 3,575 individuals aged 65 or older from wave one of the Korean Longitudinal Study of Aging (2006) was followed for 10 years (up to Wave 6, 2016). Mixed-effect logit models were used to investigate how an older adult’s social relationship characteristics (i.e., household composition, financial support from family, social group participation, and the frequency of contact with friends or relatives) were associated with their trajectories of participation in the national health screening program. Results Despite the low financial burden, only 49.7% of older adults in Korea reported receiving the recommended health screening at the baseline. Although the probability of receiving recommended health screening increased over the 10-year study period, the trajectories were significantly different by an older adult’s social relationship characteristics. All four social relationship characteristics were significantly associated with receiving health screening. However, those with more frequent social contacts and those who participated in social groups showed steeper increases in the probability of receiving health screening (i.e., significant interaction with time). Conclusions This study highlights the importance of social relationships and intervention approaches that accommodate socially isolated older adults to facilitate their timely receipt of recommended preventive care.