Miracle-dz/UniFAR-FTUs huggingface dataset:
Improving Carbon Nanotube Composites Through Interface Control via Polymer Grafting

Nanocomposites are critically influenced by interfacial interactions between the reinforcement and matrix. Single-walled carbon nanotubes (SWCNTs) were grafted with polyvinyl alcohol (PVOH) of varying molecular weights, to improve the interfacial interaction with a homopolymer PVOH matrix. Nanocomposite fibers were coagulation spun across a broad range of loading fractions, controlled by the spinning dope composition. An intermediate grafted-PVOH molecular weight (10 kDa) maximized grafting ratio, and the final composite mechanical performance; the positive effects were attributed to the increased degree of dispersion of the SWCNTs in the dope, as well as the favorable interface. The PVOH grafting stabilized increased SWCNT loading fractions (up to 45 wt.%), offering increased strength (up to 1100 MPa) and stiffness (up to 38.5 GPa); at the same time, strain-to-failures remained high (up to 23.3%), resulting in high toughness (up to 125 J g). * Corresponding author. E-mail: m.shaffer@imperial.ac. uk (Milo S. P. Shaffer),
Sub-60mV-swing negative-capacitance FinFET without hysteresis

In this work, we report the first Negative-Capacitance FinFET. ALD Hf042Zr058O2 is added on top of the FinFET's gate stack. The test devices have a floating internal gate that can be electrically probed. Direct measurement found the small-signal voltage amplified by 1.6X maximum at the internal gate in agreement with the improvement of the subthreshold swing (from 87 to 55mV/decade). ION increased by >25% for the IOFF. For the first time, we demonstrate that raising HfZrO2 ferroelectricity, by annealing at higher temperature, reduces and eliminates IV hysteresis and increases the voltage gain. These discoveries will guide future theoretical and experimental work.
Innovation policy in the post-war period

This paper provides a structured outline of innovation and industrial policies in a small and highly industrialised economy during the post-war period. Analysing the changing priorities of these policies in an open economy like Norway provides a contrasting perspective to the literature on the structure and evolution of industrial innovation policies with its bias towards US and other large country developments. The analysis lead us to introduce, inspired by Foucault’s concept of mentalities, Kuhn’s paradigms, as well as Gadamer’s life worlds, policy mentalities as a concept to characterise main dimensions of industrial policies in various period. Policy mentalities are sets of implicit and explicit assumptions and views held by the policy system about the core task and objective of industrial policy. In a sense, these policy mentalities, reflecting current views or aspirations concerning the nature and dynamics of ongoing social change, can be seen as major determinants of policy objectives. As with Foucaultian mentalities, the policy mentalities tend to persist over time. The paper briefly outlines some major trends in industrial and innovation policies in Norway, at the European level and in the US during the post-war period.
Influence of comorbidity in cancer surgery on treatment decisions, postoperative course and oncological outcome

Comorbidity in cancer patients may influence treatment decisions, postoperative morbidity and ultimately, survival. The TNM staging system does not take comorbidity into account. This study investigates the burden of comorbidity in cancer patients, its effect on resection rate, postoperative morbidity, adjuvant therapy, recurrence and survival.
Requirement of Both the Second and Third BIR Domains for the Relief of X-linked Inhibitor of Apoptosis Protein (XIAP)-mediated Caspase Inhibition by Smac*

The inhibitor of apoptosis proteins (IAP) are endogenous caspase inhibitors in the metazoan and characterized by the presence of baculoviral IAP repeats (BIR). X-linked IAP (XIAP) contains three BIR domains and directly inhibits effector caspases such as caspase-7 via a linker_BIR2 fragment and initiator caspases such as caspase-9 via the BIR3 domain. A mitochondrial protein Smac/DIABLO, which is released during apoptosis, antagonizes XIAP-mediated caspase inhibition by interacting directly with XIAP. Here, using glutathione S-transferase pulldown and caspase activity assay, we show that Smac is ineffective in relieving either caspase-7 or caspase-9 inhibition by XIAP domain fragments. In addition, Smac forms a ternary complex with caspase-7 and linker_BIR2, suggesting that Smac/linker_BIR2 interaction does not sterically exclude linker_BIR2/caspase-7 interaction. However, Smac is effective in removing caspase-7 and caspase-9 inhibition by XIAP fragments containing both the BIR2 and BIR3 domains. Surface plasmon resonance measurements show that Smac interacts with the BIR2 or BIR3 domain in micromolar dissociation constants. On the other hand, Smac interacts with an XIAP construct containing both BIR2 and BIR3 domains in a subnanomolar dissociation constant by the simultaneous interaction of the Smac dimer with the BIR2 and BIR3 domains of a single XIAP molecule. This 2:1 Smac/XIAP interaction not only possesses enhanced affinity but also sterically excludes XIAP/caspase-7 interaction, demonstrating the requirement of both BIR2 and BIR3 domains for Smac to relieve XIAP-mediated caspase inhibition.
Practical Forward-Secure Range and Sort Queries with Update-Oblivious Linked Lists

Abstract We revisit the problem of privacy-preserving range search and sort queries on encrypted data in the face of an untrusted data store. Our new protocol RASP has several advantages over existing work. First, RASP strengthens privacy by ensuring forward security: after a query for range [a, b], any new record added to the data store is indistinguishable from random, even if the new record falls within range [a, b]. We are able to accomplish this using only traditional hash and block cipher operations, abstaining from expensive asymmetric cryptography and bilinear pairings. Consequently, RASP is highly practical, even for large database sizes. Additionally, we require only cloud storage and not a computational cloud like related works, which can reduce monetary costs significantly. At the heart of RASP, we develop a new update-oblivious bucket-based data structure. We allow for data to be added to buckets without leaking into which bucket it has been added. As long as a bucket is not explicitly queried, the data store does not learn anything about bucket contents. Furthermore, no information is leaked about data additions following a query. Besides formally proving RASP’s privacy, we also present a practical evaluation of RASP on Amazon Dynamo, demonstrating its efficiency and real world applicability.
Platelet Abnormalities in Diabetes Mellitus

Although platelets can contribute to atherosclerosis and its thromboembolic complications in the nondiabetic population, the role of platelets in enhanced vascular disease in the diabetic population remains unclear. Most studies indicate that platelet function in vitro is enhanced in platelets from people and animals with diabetes, and the mechanisms are being identified. There remains some controversy about whether platelet changes occur before, and therefore could contribute to, vascular complications or whether they are secondary to vascular disease. It is possible that only intervention trials to determine if inhibiting platelet function limits the progression of vascular disease in diabetic patients will definitively answer this question. The earlier premise that enhanced activity of the arachidonate pathway is responsible for the hypersensitivity of platelets from diabetic humans needs to be modified to recognize that additional mechanisms are involved in platelet activation and are modified in people with diabetes and also that altered activity of the arachidonate pathway may reflect changes in earlier pathways involved in platelet activation. Clearly, alterations in these nonarachidonate pathways need to be taken into account when considering the appropriate antiplatelet agents to use in intervention trials. Information about whether hypersensitivity of platelets from people with diabetes persists in vivo and, if so, how this influences platelet-vessel wall interactions and thrombotic tendencies needs to be pursued more intensely in suitable animal models so that the theories developed from studies in vitro can be tested in the more complex environment in vivo. These are important areas for research in the future.
Design of an information skimming space

This paper proposes the Information Skimming Space (ISS) which provides users with a window through which interesting news reports can be culled from the large number of reports created daily by the mass media, such as newspapers and TV stations, as well as serving as a powerful information retrieval system. Our idea is that information acquisition can be best performed by enhancing the efficiency with which the information is presented to and accessed by the user. To realize this concept, newspapers are analyzed as an information acquisition tool to make an effective presentation scheme suitable for rapid cognitive understanding. News Transmission Model is proposed to define navigation paths that allow the user to access other reports according to his or her interests.
Integrated Hardware Architecture for Efficient Computation of the $n$-Best Bio-Sequence Local Alignments in Embedded Platforms

A flexible hardware architecture that implements a set of new and efficient techniques to significantly reduce the computational requirements of the commonly used Smith-Waterman sequence alignment algorithm is presented. Such innovative techniques use information gathered by the hardware accelerator during the computation of the alignment scores to constrain the size of the subsequence that has to be post-processed in the traceback phase using a general purpose processor (GPP). Moreover, the proposed structure is also capable of computing the n-best local alignments according to the Waterman-Eggert algorithm, becoming the first hardware architecture that is able to simultaneously evaluate the n-best alignments of a given sequence pair, by incorporating a set of ordering units that work in parallel with the systolic array. A complete alignment system was developed and implemented in a Virtex-4 FPGA, by integrating the proposed accelerator architecture with a Leon3 GPP. The obtained experimental results demonstrate that the proposed system is flexible and allows the alignment of large sequences in memory constrained systems. As an example, a speedup of 17 was obtained with the conceived system when compared with a regular implementation of the LALIGN35 program running on an Intel Core2 Duo processor running at a 40 × higher frequency.
3D Models in Cultural Heritage: Approaches for Their Creation and Use

Metric surveys are a key component in Cultural Heritage. Metric surveys are in fact a basic input for a wide range of activities, from documentation to study, from restoration to valorization, that rely on the current condition of the monument. In recent years, laser scanning and, more recently, digital photogrammetry offered new perspectives, widening the perspectives of 3D Cultural Heritage recording. Digital technologies provide new ways to collaborate, record excavations, and restore artifacts, and in such a way they are transforming the way Cultural Heritage practitioners researchers, archaeologists, curators work. This paper attempts to review the methods for 3D digitization that are today available and discuss the possible use of 3D models beyond the pure extraction of reliable and accurate measures.
Increased Cardiovascular Reactivity to Acute Stress and Salt-Loading in Adult Male Offspring of Fat Fed Non-Obese Rats

Diet-induced obesity in rat pregnancy has been shown previously to be associated with consistently raised blood pressure in the offspring, attributed to sympathetic over-activation, but the relative contributions to this phenotype of maternal obesity versus raised dietary fat is unknown. Sprague-Dawley female rats were fed either a control (4.3% fat, n = 11) or lard-enriched (23.6% fat, n = 16) chow 10 days prior to mating, throughout pregnancy and lactation. In conscious adult (9-month-old) offspring cardiovascular parameters were measured (radiotelemetry). The short period of fat-feeding did not increase maternal weight versus controls and the baseline blood pressure was similar in offspring of fat fed dams (OF) and controls (OC). However, adult male OF showed heightened cardiovascular reactivity to acute restraint stress (p<0.01; Δ systolic blood pressure (SBP) and Δheart rate (HR)) with a prolonged recovery time compared to male OC. α1/β-adrenergic receptor blockade normalised the response. Also, after dietary salt-loading (8%-NaCl ad libitum for 1 week) male OF demonstrated higher SBP (p<0.05) in the awake phase (night-time) and increased low/high frequency ratio of power spectral density of HR variability versus OC. Baroreflex gain and basal power spectral density components of the heart rate or blood pressure were similar in male OF and OC. Minor abnormalities were evident in female OF. Fat feeding in the absence of maternal obesity in pregnant rats leads to altered sympathetic control of cardiovascular function in adult male offspring, and hypertension in response to stressor stimuli.
Charting the audience perceptions of projected 3D media installations

In this paper we present our work on exploring the possibilities of using 3D projection, instead of 2D displays, for a media installation set-up, which we aim to use for exhibition and teaching purposes. We compare two visual media installations presenting a rotating Earth, one presented on a 2D display and the other projected on a physical 3D object, and present the feedback collected by using the product evaluation cards method.
Differential charge pump circuit for high speed PLL application

A high performance fully differential charge pump with reference voltage circuit was proposed to overcome the inevitable disadvantages in the traditional charge pump circuit, including leakage current, charged/discharge current mismatch and the output ripple. The phase errors and the spurious jump were reduced greatly, and the stability of the output was improved. The characteristics of wide swing range of output and low mismatch rate of currents of the charge pump met the high performance of high speed phase locked loop application requirement.
Margin-based active learning and background knowledge in text mining

Text mining, also known as intelligent text analysis, text data mining or knowledge-discovery in text, refers generally to the process of extracting interesting and nontrivial information and knowledge from text. One of the main problems with text mining and classification systems is the lack of labeled data, as well as the cost of labeling unlabeled data (Kiritchenko and Matwin 2001). Thus, there is a growing interest in exploring the use of unlabeled data as a way to improve classification performance in text classification. The ready availability of this kind of data in most applications makes it an appealing source of information. In this work we evaluate the benefits of introducing unlabeled data in a support vector machine automatic text classifier. We further evaluate the possibility of learning actively and propose a method for choosing the samples to be learned.
Gate and Common Pathway Detection in Crowd Scenes Using Motion Units and Meta-Tracking

This paper proposes a new approach for analysing crowded video scenes. The proposed approach decomposes the scene motion dynamics into a graph of interconnected atomic elements of coherent motions named Motion Units (MUs). Different MUs cover scene's local regions with different size and shape, which can even overlap. MUs relationships are analysed to discover the scene entrances and exits. Dominant motion pathways are then discovered by meta-tracking of particles injected at the scene entrances and driven through MUs using their linear dynamical systems until reaching scene exits. A prototype is developed such that; MUs are constructed by tracklet clustering, MU's motion pattern is represented by a linear model, and the MUs relationships are defined by the continuation likelihood among their mean tracklets. The prototype was evaluated on the challenging New York Grand Central Station scene, as well as other crowded scenes, and it managed to outperform the state of the art approaches.
Recognition of Human Activities Using Continuous Autoencoders with Wearable Sensors

This paper provides an approach for recognizing human activities with wearable sensors. The continuous autoencoder (CAE) as a novel stochastic neural network model is proposed which improves the ability of model continuous data. CAE adds Gaussian random units into the improved sigmoid activation function to extract the features of nonlinear data. In order to shorten the training time, we propose a new fast stochastic gradient descent (FSGD) algorithm to update the gradients of CAE. The reconstruction of a swiss-roll dataset experiment demonstrates that the CAE can fit continuous data better than the basic autoencoder, and the training time can be reduced by an FSGD algorithm. In the experiment of human activities’ recognition, time and frequency domain feature extract (TFFE) method is raised to extract features from the original sensors’ data. Then, the principal component analysis (PCA) method is applied to feature reduction. It can be noticed that the dimension of each data segment is reduced from 5625 to 42. The feature vectors extracted from original signals are used for the input of deep belief network (DBN), which is composed of multiple CAEs. The training results show that the correct differentiation rate of 99.3% has been achieved. Some contrast experiments like different sensors combinations, sensor units at different positions, and training time with different epochs are designed to validate our approach.
Type I Interferon as a Powerful Adjuvant for Monocyte-Derived Dendritic Cell Development and Activity in Vitro and in Hu-Pbl-Scid Mice

Type I interferons (IFNs) are cytokines exhibiting antiviral and antitumor effects, including multiple activities on immune cells. However, the importance of these cytokines in the early events leading to the generation of an immune response is still unclear. Here, we have investigated the effects of type I IFNs on freshly isolated granulocyte/macrophage colony-stimulating factor (GM-CSF)–treated human monocytes in terms of dendritic cell (DC) differentiation and activity in vitro and in severe combined immunodeficiency mice reconstituted with human peripheral blood leukocytes (hu-PBL-SCID) mice. Type I IFNs induced a surprisingly rapid maturation of monocytes into short-lived tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)–expressing DCs endowed with potent functional activities, superior with respect to the interleukin (IL)-4/GM-CSF treatment, as shown by FACS® analyses, mixed leukocyte reaction assays with allogeneic PBLs, and lymphocyte proliferation responses to HIV-1–pulsed autologous DCs. Type I IFN induced IL-15 production and strongly promoted a T helper cell type 1 response. Notably, injection of IFN-treated HIV-1–pulsed DCs in SCID mice reconstituted with autologous PBLs resulted in the generation of a potent primary immune response, as evaluated by the detection of human antibodies to various HIV-1 antigens. These results provide a rationale for using type I IFNs as vaccine adjuvants and support the concept that a natural alliance between these cytokines and monocytes/DCs represents an important early mechanism for connecting innate and adaptive immunity.
Notes on the role of dynamic DNA methylation in mammalian development

It has been nearly 40 y since it was suggested that genomic methylation patterns could be transmitted via maintenance methylation during S phase and might play a role in the dynamic regulation of gene expression during development [Holliday R, Pugh JE (1975) Science 187(4173):226–232; Riggs AD (1975) Cytogenet Cell Genet 14(1):9–25]. This revolutionary proposal was justified by “. our almost complete ignorance of the mechanism for the unfolding of the genetic program during development” that prevailed at the time. Many correlations between transcriptional activation and demethylation have since been reported, but causation has not been demonstrated and to date there is no reasonable proof of the existence of a complex biochemical system that activates and represses genes via reversible DNA methylation. Such a system would supplement or replace the conserved web of transcription factors that regulate cellular differentiation in organisms that have unmethylated genomes (such as Caenorhaditis elegans and the Dipteran insects) and those that methylate their genomes. DNA methylation does have essential roles in irreversible promoter silencing, as in the monoallelic expression of imprinted genes, in the silencing of transposons, and in X chromosome inactivation in female mammals. Rather than reinforcing or replacing regulatory pathways that are conserved between organisms that have either methylated or unmethylated genomes, DNA methylation endows genomes with the ability to subject specific sequences to irreversible transcriptional silencing even in the presence of all of the factors required for their expression, an ability that is generally unavailable to organisms that have unmethylated genomes.
Long-term safety of aromatase inhibitors in the treatment of breast cancer

Following promising data for metastatic breast cancer in terms of efficacy and safety profile, third-generation aromatase inhibitors (AI), anastrozole, letrozole, and exemestane, underwent a full development in early setting. If recent results consistently show the superiority of these agents over tamoxifen, the therapeutic strategies of AIs in adjuvant setting are still debated. Beyond the choice of clinical strategy, the long duration of exposure to AI in adjuvant setting required a full determination of the long-term toxicity profile of these agents. While all three AIs have either favorable (decreased incidence of hot flashes, gynecologic and thromboembolic side-effects) or unfavorable (skeletal complications, arthralgia, musculoskeletal pain, sexual dysfunction) class adverse events, some variability between AIs has been reported in side-effects as well as gastrointestinal, urogenital, neurologic, and visual disturbances, confirming the lack of interchangeability between the three AIs. The overall therapeutic index of AIs appears today superior to that of tamoxifen with proven improved efficacy and better toxicity profile. This review will explore the results from the available adjuvant AIs trials with a particular emphasis on safety profiles, quality of life, and therapeutic index, helping to define the present role of AIs in the adjuvant management of postmenopausal patients with breast cancer.