Miracle-dz/UniFAR-FTUs huggingface dataset:
A Framework for Mobile User Activity Logging

The goal of this work is a unified approach for collecting data about user actions on mobile devices in an appropriate granularity for user modeling. To fulfill this goal, we have designed and implemented a framework for mobile user activity logging on Windows Mobile PDAs based on the MyExperience project. We have extended this system with hardware and software sensors to monitor phone calls, messaging, peripheral devices, media players, GPS sensors, networking, personal information management, web browsing, system behavior and applications usage. It is possible to detect when, at which location and how a user employs an application or accesses certain information, for example. To evaluate our framework, we applied it in several usage scenarios. We were able to validate that our framework is able to collect meaningful information about the user.
Are Base-Stock Policies Optimal in Inventory Problems with Multiple Delivery Modes?

We present a periodic review inventory model with multiple delivery modes. While base-stock policies are optimal for one or two consecutive delivery modes, they are not so otherwise. For multiple consecutive delivery modes, we show that only the fastest two modes have optimal base stocks, and provide a simple counterexample to show that the remaining ones do not. We investigate why the base-stock policy is or is not optimal in different situations. This note is an abridged version of Feng et al. (2006).
An Energy-Efficient Dynamic Key Management in Wireless Sensor Networks

Wireless sensor networks (WSNs) consist of small sensor nodes with constrained energy, memory and computation capabilities. They are often deployed in the unattended and hostile environment. Therefore sensor nodes are vulnerable to attacks such as node capture and collusion attack by adversaries. To protect the whole network, cryptographic techniques are necessary that pairwise key establishment is the essential procedure. It enables that sensor nodes can communicate to each other securely. However, it is impractical to use traditional key management techniques such as public key cryptography and key distribution center (KDC) because of the resource constraints of sensor nodes. This paper proposes a key distribution scheme, based on exclusion-based systems (EBSs) and t-degree bivariate polynomials. It is an energy-efficient dynamic key management scheme which performs localized rekeying to minimize overhead.
Retrieval and Reuse of Pituitary Secretory Granule Proteins*

The pituitary contains professional secretory cells, devoting a large fraction of their energy to the synthesis of hormones that are stored for secretion in response to a complex mixture of inputs. Ba2+, a substitute for Ca2+, and phorbol ester, a mimic for diacylglycerol, have a synergistic effect on exocytosis. By using these secretagogues, we developed a paradigm in which phorbol ester potentiation of Ba2+-evoked exocytosis produces a robust secretory response in multiple pituitary cell types. Because cells subjected to this stimulatory paradigm remain healthy despite their greatly reduced hormone content, we used this paradigm to study the fate of granule membrane proteins. We examined the turnover of peptidylglycine α-amidating monooxygenase (PAM), a membrane enzyme involved in the final maturation of many peptides, and VAMP2, a vesicle soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE). The stability of recently synthesized PAM was increased by sustained exocytosis. Biotinylation studies established that the appearance of integral membrane PAM at the plasma membrane was stimulated along with hormone secretion. PAM biotinylated on the cell surface undergoes cleavage to yield soluble peptidylglycine-α-hydroxylating monooxygenase that can then be secreted in a regulated fashion. Consistent with a kiss-and-run or cavicapture mode of secretion (Taraska, J. W., Perrais, D., Ohara-Imaizumi, M., Nagamatsu, S., and Almers, W. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 2070–2075), biotinylated prolactin was also retained by the cells and later released in response to secretagogues. Thus, pituitary cells can retrieve and reuse components of the machinery involved in the final stages of exocytosis (the SNAREs) as well as soluble and membrane granule proteins.
Decreased glomerular filtration rate in solderers exposed to cadmium.

OBJECTIVES--to evaluate the degree of cadmium induced glomerular impairment and to assess the dose-response relation between cadmium dose and the prevalence of glomerular dysfunction. METHODS--A comparison of glomerular filtration rates (GFR) assessed by Cr-EDTA clearance was made in 42 solderers previously exposed to cadmium for at least five years. Blood and urine data were collected at health examinations in 1984, 1989, and 1993. Individual doses of cadmium were estimated by analysing cadmium in blood. RESULTS--Glomerular lesions induced by cadmium are irreversible and the GFR decreases with the degree of tubular damage. The GFR also decreases with cadmium dose and there is a dose-response relation between blood cadmium and prevalence of glomerular damage with 3.4% prevalence at blood cadmium concentrations below 50 nmol/l, 33% at blood cadmium concentrations between 50 and 75 nmol/l and 100% prevalence of glomerular damage when cadmium in blood exceeds 75 nmol/l. CONCLUSIONS--The kidney lesions induced by cadmium are irreversible and the prevalence of those lesions are dose dependent. There is also evidence of a dose related decrease in GFR even a long time after the end of exposure. Exposure to cadmium should therefore be minimised and workers exposed to cadmium should be examined regularly for many years after the end of exposure.
Study of MRSP - A Comparison Study ofDiversity, Relevance, Importance in Ranking

Information retrieval is an everyday task for different domain area users for specific task related to their area of interest for knowledge discovery (KDD), Decision makings etc. Data mining techniques plays a vital role for extracting information related to user search. Search Engines involves in retrieving of Users’ queries by searching in multiple databases. As the users of the technology growing rapidly, the enormous collection of data in sort of data links & maintaining of that data by storing in databases became a big problem for companies to retrieve the Information Relevance to the given query, users are totally depending on the retrieval data. Here comes the actual problem in estimating the Relevance, Importance and divergence of the result obtained. Ranking is the primary concept in displaying any result on Web based Systems (WS), Automated Systems (AS), Information Retrieval Systems (IRS) by fulfilling the common properties. In this paper we discussed in ranking properties, divergence problems and studied an approach -Manifold ranking with sink points (MRSP) to address diversity as well as relevance and importance in ranking.
A multi-chip module implementation of a neural network

The requirement for dense interconnect in artificial neural network systems has led researchers to seek high-density interconnect technologies. This paper reports an implementation using multi-chip modules (MCMs) as the interconnect medium. The specific system described is a self-organizing, parallel, and dynamic learning model which requires a dense interconnect technology for effective implementation; this requirement is fulfilled by exploiting MCM technology. The ideas presented in this paper regarding an MCM implementation of artificial neural networks are versatile and can be adapted to apply to other neural network and connectionist models. <<ETX>>
Inference of S-system models of genetic networks by solving linear programming problems and sets of linear algebraic equations

For the inference of S-system models of genetic networks, this study proposes a new method, i.e., a two-phase estimation method. The two-phase estimation method is an extension of the decoupling approach proposed by Voit and Almeida. The decoupling approach defines the estimation of S-system parameters as a problem of solving sets of non-linear algebraic equations. Our method first transforms each set of non-linear algebraic equations, that is defined by the decoupling approach, into a set of linear ones. The transformation of the equations is easily accomplished by solving a linear programming problem. The proposed method then estimates S-system parameters by solving the transformed linear equations. As the proposed two-phase estimation method infers an S-system model only by solving linear programming problems and sets of linear algebraic equations, it always provides us with a unique solution. Moreover, its computational cost is very low. Finally, we confirm the effectiveness of the proposed method through numerical experiments.
Enumeration of snakes and cycle-alternating permutations

Springer numbers are an analog of Euler numbers for the group of signed permutations. Arnol'd showed that they count some objects called snakes, that generalize alternating permutations. Hoffman established a link between Springer numbers, snakes, and some polynomials related with the successive derivatives of trigonometric functions. The goal of this article is to give further combinatorial properties of derivative polynomials, in terms of snakes and other objects: cycle-alternating permutations, weighted Dyck or Motzkin paths, increasing trees and forests. We obtain the generating functions, in terms of trigonometric functions for exponential ones and in terms of J-fractions for ordinary ones. We also define natural q-analogs, make a link with normal ordering problems and combinatorial theory of differential equations.
Single Cell Analysis of Lymph Node Tissue from HIV-1 Infected Patients Reveals that the Majority of CD4+ T-cells Contain One HIV-1 DNA Molecule

Genetic recombination contributes to the diversity of human immunodeficiency virus (HIV-1). Productive HIV-1 recombination is, however, dependent on both the number of HIV-1 genomes per infected cell and the genetic relationship between these viral genomes. A detailed analysis of the number of proviruses and their genetic relationship in infected cells isolated from peripheral blood and tissue compartments is therefore important for understanding HIV-1 recombination, genetic diversity and the dynamics of HIV-1 infection. To address these issues, we used a previously developed single-cell sequencing technique to quantify and genetically characterize individual HIV-1 DNA molecules from single cells in lymph node tissue and peripheral blood. Analysis of memory and naïve CD4+ T cells from paired lymph node and peripheral blood samples from five untreated chronically infected patients revealed that the majority of these HIV-1-infected cells (>90%) contain only one copy of HIV-1 DNA, implying a limited potential for productive recombination in virus produced by these cells in these two compartments. Phylogenetic analysis revealed genetic similarity of HIV-1 DNA in memory and naïve CD4+ T-cells from lymph node, peripheral blood and HIV-1 RNA from plasma, implying exchange of virus and/or infected cells between these compartments in untreated chronic infection.
Management issues with exogenous steroid therapy

Glucocorticoids (GCs) are extensively used for various inflammatory and autoimmune disorders, but long term use of these agents is not without complications. Almost every GC formulations (e.g. oral, topical, inhaled, etc.) can cause systemic side effects. It can range from minor side effects (e.g. weight gain) to life-threatening effects (e.g. adrenal suppression, sepsis, etc.), which may require immediate intervention. Therefore, the decision to institute steroid therapy always requires careful consideration of the relative risk and benefit in each patient. The objectives of this study are to discuss monitoring of patients on GCs and management of the complications of GCs.
Flow similarity, stochastic branching, and quarter-power scaling in plants

Abstract The origin of allometric scaling patterns that are multiples of one-fourth has long fascinated biologists. While not universal, quarter-power scaling relationships are common and have been described in all major clades. Several models have been advanced to explain the origin of such patterns, but questions regarding the discordance between model predictions and empirical data have limited their widespread acceptance. Notable among these is a fractal branching model that predicts power-law scaling of both metabolism and physical dimensions. While a power law is a useful first approximation to some data sets, nonlinear data compilations suggest the possibility of alternative mechanisms. Here, we show that quarter-power scaling can be derived using only the preservation of volume flow rate and velocity as model constraints. Applying our model to land plants, we show that incorporating biomechanical principles and allowing different parts of plant branching networks to be optimized to serve different functions predicts nonlinearity in allometric relationships and helps explain why interspecific scaling exponents covary along a fractal continuum. We also demonstrate that while branching may be a stochastic process, due to the conservation of volume, data may still be consistent with the expectations for a fractal network when one examines sub-trees within a tree. Data from numerous sources at the level of plant shoots, stems, and petioles show strong agreement with our model predictions. This theoretical framework provides an easily testable alternative to current general models of plant metabolic allometry.
Comparing tactical and commercial MANETs design strategies and performance evaluations

Mobile tactical networks (MTNs) in military communications extend the capabilities of mobile ad-hoc networks (MANETs). The MTNs are dynamic, infrastructureless, self-forming and self-healing systems designed for non-line-of-sight (NLOS) operations using multi-hop relaying. Unlike their commercial counterparts, MTNs have to offer much higher levels of security, jamming resistance, and service robustness in the adverse propagation environments without sacrificing or limiting data rate, latency, and node mobility while also controlling the network capital and operational costs. Comprehensive comparison of the performance and design characteristics of the commercial MANETs and their military counterparts is carried out using NS2 simulations. It is found that, for scenarios requiring long-range connectivity, a reference point group mobility (RPGM) model and a two-way ground radio propagation model give the most accurate performance predictions for MTNs. Finally, it is argued that many commercial off-the-shelf (COTS) technologies can be adopted for their use in MTNs, even though it requires a lot of additional efforts to overcome challenges not considered by the commercial solutions.
Unit cell with flexible transmission phase slope for ultra‐wideband transmitarray antennas

Having studied the transmitarray antennas, it is found that the cells depending on their location on the antenna aperture should have a specific slope in the transmission phase diagram in terms of frequency. The central cell has the most negative slope, and as long as the centre is farther away, the negative slope of the transmission phase diagram in terms of frequency is reduced. Therefore, the ability to change the slope of the transmission phase diagram in terms of frequency in the unit cell is essential. To validate the proposed approach, by providing a suitable unit cell, a typical X-band antenna with an aperture size of 20. 55λ 0 2 at 10 GHz has been designed, fabricated, and tested. In order to evaluate the effect of the transmit array aperture, the gain enhancement value of the antenna is calculated and maximum gain of 5.9 dBi at 10.5 GHz and a 29.71% 1 dB gain bandwidth is achieved.
Odynophagia in Esophageal Cancer Patients Treated with High Dose Brachytherapy (HDRBT) - Results from A Prospective Study of Fungal Infections

In esophageal cancer patient’s fungal infections and esophagitis can be the cause of odynophagia. Seventy nine consecutive patients with biopsy proven locally advanced esophageal cancer receiving HDRBT were evaluated. All patients received a dose of 18 Gy in 3 fractions on alternate days. All patients had endoscopy performed before, during and after brachytherapy treatment. The endoscopic presence of white or yellow mucosal patches in the esophagus surrounded by erythema was considered to be consistent with underlying fungal infection (FI). Twenty nine patients (36.7%) complained of odynophagia between fractions or after brachytherapy treatments. Clinically proven fungal infection on esophagoscopy was observed in 13/29 (44.8%) patients. The mean time to odynophagia was 12 days (range: 1- 26) after the first brachytherapy fraction. Odynophagia improved in 11/13 (84.6%) of patients after oral Nystatin therapy. Only 2/13 (15.4%) patients required additional oral Fluconazole before odynophagia was relieved. In patients with esophageal cancer who have received brachytherapy and are complaining of odynophagia, Nystatin should be routinely used for treatment and prophylaxis.
Electromagnetic Energy Harvesting for Wireless Body Area Networks with Cognitive Radio Capabilities

Cognitive radio (CR) is a promising technology for future body area networks (BodyNets). It enables unlicensed (secondary) users to exploit the spectrum allocated to licensed (primary) users in an opportunistic manner. Innovative, energy efficient medium access control (MAC) and routing protocols must be implemented to improve the coexistence between different users, as well as managing the scarce resources in an efficient way. Besides this verification of spectrum opportunities and sensing methods, this work addresses physical (PHY), MAC and network layer design aspects for BodyNets. Furthermore, based on field trials made in real indoor and outdoor environments, we address existing CR opportunities to be applied to potential applications in body area and sensor networks. Our research includes a scenario where a BodyNet is being sustained by radio frequency (RF) energy harvesting devices, that convert low energy RF to direct current (DC), providing an alternative source to power supply the wireless sensor network (WSN) devices.
Evaluation of CA 125 Levels in Differentiating Malignant From Benign Tumors in Patients With Pelvic Masses

Serum CA 125 levels were assayed from 44 normal healthy women, 153 patients with benign pelvic masses, and 58 patients with malignant pelvic masses. CA 125 levels were less than 35 U/mL in 42 of the 44 normal women and were greater than 35 but less than 65 U/mL in the other two women. Among 153 patients with benign pelvic masses, CA 125 levels greater than 35, 65, or 194 U/mL were detected in 61 (39.9%), 31 (20.3%), and eight (5.2%) patients, respectively. Of 58 patients with malignant pelvic masses, CA 125 results were greater than 35, 65, or 194 U/mL in 48 (82.8%), 45 (77.6%), and 38 (65.5%), respectively. Among the latter group, the positivity rates of 30 patients with epithelial ovarian cancers were 100, 93, and 80%, respectively. This study suggests that defining positive serum CA 125 levels as those greater than 35 U/mL is of limited clinical value because there is a 39.9% false-positive rate in patients with benign disease. However, serum CA 125 values greater than 65 U/mL may be considered positive in clinically normal women. Serum CA 125 greater than 194 U/mL, representing the units at the 95th percentile for 153 patients with benign pelvic masses, is defined as a new positivity criterion, and could be used to differentiate malignant tumors from benign pelvic masses.
On the invertibility of invisible watermarking techniques

We shall show that non-invertibility is a necessary but not sufficient condition in resolving ownership disputes. We then define quasi-invertible watermarking schemes, and, present analysis that links invertibility and quasi-invertibility to some classes of watermarking techniques with different properties (which may or may not require original versions in watermark decoding), as well as to the different classes of attacks we have developed.
HMDs, caves & chameleon: a human-centric analysis of interaction in virtual space

There are a various approaches to implementing virtual reality (VR) systems. The head mounted display (HMD) and Cave approaches are two of the best known. In this paper, we discuss such approaches from the perspective of the types of interaction that they afford. Our analysis looks at interaction from three perspectives: solo interaction, collaborative interaction in the same physical space and remote collaboration. From this analysis emerges a basic taxonomy that is intended to help systems designers make choices that better match their implementation with the needs of their application and users.
Hodgkin's disease and the risk of acute leukemia in successfully treated patients.

Intensive BFM chemotherapy for childhood ALL: interim analysis of the AIEOP-ALL 91 study Valentino Conter, Maurizio Aricò, Maria Grazia Valsecchi, Carmelo Rizzari, Annamaria Testi, Roberto Miniero, Maria Teresa Di Tullio, Luca Lo Nigro, Andrea Pession, Roberto Rondelli, Chiara Messina, Nicola Santoro, Pier Giorgio Mori, Giulio De Rossi, Paolo Tamaro, Daniela Silvestri, Andrea Biondi, Giuseppe Basso, Giuseppe Masera for the “Associazione Italiana Ematologia Oncologia Pediatrica” (AIEOP) . 791-799
Nonequivalent Gene Expression and Copy Number Alterations in High-Grade Serous Ovarian Cancers with BRCA1 and BRCA2 Mutations

Purpose: High-grade serous carcinoma (HGSC) accounts for the majority of epithelial ovarian cancer deaths. Genomic and functional data suggest that approximately half of unselected HGSC have disruption of the BRCA pathway and defects in homologous recombination repair (HRR). Pathway disruption is regarded as imparting a BRCAness phenotype. We explored the molecular changes in HGSC arising in association with specific BRCA1/BRCA2 somatic or germline mutations and in those with BRCA1 DNA promoter methylation. Experimental Design: We describe gene expression and copy number analysis of two large cohorts of HGSC in which both germline and somatic inactivation of HRR has been measured. Results: BRCA1 disruptions were associated with the C2 (immunoreactive) molecular subtype of HGSC, characterized by intense intratumoral T-cell infiltration. We derived and validated a predictor of BRCA1 mutation or methylation status, but could not distinguish BRCA2 from wild-type tumors. DNA copy number analysis showed that cases with BRCA1 mutation were significantly associated with amplification both at 8q24 (frequencies: BRCA1 tumors 50%, BRCA2 tumors 32%, and wild-type tumors 9%) and regions of the X-chromosome specifically dysregulated in basal-like breast cancer (BLBC; BRCA1 62%, BRCA2 34%, and wild-type 35%). Tumors associated with BRCA1/BRCA2 mutations shared a negative association with amplification at 19p13 (BRCA1 0%, BRCA2 3%, and wild-type 20%) and 19q12 (BRCA1 6%, BRCA2 3%, and wild-type 29%). Conclusion: The molecular differences between tumors associated with BRCA1 compared with BRCA2 mutations are in accord with emerging clinical and pathologic data and support a growing appreciation of the relationship between HGSC and BLBC. Clin Cancer Res; 19(13); 3474–84. ©2013 AACR.