Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of intraruminal propionate supplementation on nitrogen utilisation by the portal-drained viscera, the liver and the hindlimb in lambs fed frozen rye grass

The influence of propionate supplementation on the splanchnic metabolism of amino acids (AA) and other N compounds (urea-N and NH3-N) and the supply of AA and NH3-N to the hindlimb was investigated in growing lambs. Six rumen-cannulated and multicatheterised lambs (32·2kg) were fed frozen rye grass at 690kJ metabolisable energy intake/d per kg average metabolic body weight. They were infused intraruminally with a salt solution (control) or with propionate solutions at 0·23mol/l (P1) or 0·41mol/l (P2) infused at a maximal rate of 1·68 (sd 0·057) ml/min according to a repeated Latin square design. The propionate infusion did not increase the net portal appearance of total AA (TAA)-N but increased that of some branched-chain AA (valine and to a lesser extent isoleucine). Simultaneously, the propionate treatment (especially P2) induced an increased TAA utilisation by the liver. This was due mainly to an increased (+79%; P<0·07) utilisation of the essential AA and particularly the branched-chain AA. A stimulation of protein synthesis in the liver is hypothesised since (1) propionate stimulated insulin secretion and (2) utilisation of non-essential AA were less influenced by the propionate treatment in the liver (except for alanine), suggesting that the AA utilised by the liver were directed towards protein synthesis rather than towards oxidation or urea synthesis. At the splanchnic level, the propionate treatment did not have any effect on the TAA, non-essential AA and essential AA, except for a net splanchnic release that was decreased for leucine (P<0·02) and methionine (P<0·01) and increased for threonine (P<0·05). The propionate treatment did not have any effect on the hindlimb uptake of AA (essential and non-essential). As a consequence, even though the propionate treatment induced some major alterations in the splanchnic metabolism of AA, there were no changes in the net AA balance in the hindlimb (and hence probably on muscle growth). The role of the splanchnic tissues in the regulation of the AA supply to the peripheral tissues (such as muscle) therefore appears to be prominent in the regulation of muscle growth. Whether the peripheral tissues regulate their own supply by interacting with the splanchnic tissues (and especially the liver) or the liver is the only regulator of the AA supply to the muscle remains in doubt.
Musical imagery : hearing and imagining music

Musical imagery is defined as the conscious 'inner hearing' of a mental representation of music. In spite of the apparent importance of imagery for musical activity, there is a dearth of empirical knowledge on the subject, due in part to its essentially private and internal nature. Psychological methods of examining the phenomenon are necessarily restricted to indirect research techniques. This thesis explores the intuition that musical imagery is central to musical thought, through an exploration of its occurrence and its character in a variety of musical activities. Three categories of musical imagery are described. First, musical imagery can occur unintentionally - the phenomenon often called 'tune on the brain'. Second, musical imagery may be an involuntary consequence of musical activity. Finally, imagery may be intentional, as in the ‘silent' analysis of musical score. The studies reported progress from unintentional to intentional imagery, combining a variety of methods in increasingly specialised musical contexts to investigate the relationship between imagery and perception. The subject is approached through theoretical discussion, a sampling study, experiments, fieldwork, and interviews with expert musicians. It is argued that musical imagery and perception are separable but mutually dependent cognitive phenomena. The results highlight a shifting relationship between perception and imagery depending upon the contextual factors of image intentionality and musical task. Evidence is provided for the prevalence of 'tune on the brain' episodes in everyday life. The veridicality of imagery for different musical dimensions is also explored, with the experiment finding that tirnbre is a less stable component of musical imagery than timing and pitch. Musical imagery is described as situated between the subconscious influence of mental representations during the pure perception of music, and the rare occurrence of eidetic imagery.
Performance analysis of Fuzzy logic based speed control of DC motor.

In this paper we have designed a separately excited DC motor whose speed can be controlled using PID and fuzzy tuned PID controller first, the fuzzy logic controller is designed according to fuzzy rules so that the systems are fundamentally robust. There are 25 fuzzy rules for self-tuning of each parameter of PID controller. The FLC has two inputs. One is the motor speed error second is change in speed error and the output of the FLC i.e. the parameters of PID controller are used to control the speed of the separately excited DC Motor. The fuzzy self-tuning approach implemented on a conventional PID structure was able to improve the dynamic as well as the static response of the system. Comparison between the conventional output and the fuzzy self-tuning output was done on the basis of the simulation result obtained by MATLAB. The simulation results demonstrate that the designed self-tuned PID controller realize a good dynamic behavior of the DC motor, a perfect speed tracking with less rise and settling time, minimum overshoot, minimum steady state error and give better performance compared to conventional PID controller.
Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: Evidence for genomic instability

Secondary malignancies (SMs) in Hodgkin lymphoma (HL) are thought to be related to exposure to alkalating agents, topoisomerase II inhibitors and ionizing radiation, and tend to occur a decade after initial therapy. We report a 14 year old autistic male, who developed malignant fibrous histiocytoma (MFH) two years after autologous stem cell transplantation for advanced stage HL. The MFH and post‐surgical reactive tissues exhibited multiple clonal abnormalities. In addition, PHA‐stimulated peripheral blood lymphocytes showed increased frequency of non‐clonal chromosomal aberrations. The potential role of genomic instability in early onset of SM in our patient is discussed. Pediatr Blood Cancer 2011;56:1143–1145. © 2010 Wiley‐Liss, Inc.
Noise reduction in magneto-acousto-electrical NDT using analytic wavelet thresholding

The Noise reduction techniques with wavelet transform are widely used in non-destructive testing and evaluation (NDT&E). In this paper, a new non-destructive testing method referred to as magneto-acousto-electrical NDT was proposed. At the same time, based on fully taking into account the signal features we employ analytic wavelet thresholding method to improve the de-noising performance. The experimental results clearly demonstrate that the proposed de-noising method has good performance in terms of signal-to-noise ratio enhancement.
DG-RBF Feed Forward Neural Networks for Pattern Classification of Handwritten English Curve Scripts

The purpose of this study is to evaluate the performance analysis of multilayer feed forward neural networks trained with back propagation algorithm & descent gradient Radial basis function network for the pattern classification of hand written curve script. This analysis has been done for handwritten text of three letters and for the individual English vowels. This analysis in the performance has been evaluated for the five different samples of handwritten English vowels and handwritten text of the three letters. Evaluation process is executed upon raw data in binary form and data based on extracted features (tangent values & density value) for each word & vowels. These characters are presented to the neural network for the training. Adjusting the connection strength and network parameters perform the training process in the neural network. The results of 3600 experiments indicate that the feed forward MLP performs accurately and exhaustively with imposed DG-RBF method. Key wordsPattern Classification, Feed forward neural network, Back propagation algorithm, Radial Basis Function Neural Network.
An improved LMI condition for robust D-stability of uncertain polytopic systems

A sufficient condition for robust D-stability of linear systems with polytope type uncertainties is proposed. The result is based on a linear parameter dependent Lyapunov function obtained from the feasibility test of a set of linear matrix inequalities defined at the vertices of the polytope. This improved linear matrix inequality condition encompasses previous results based on additional inequalities as well as results based on extra variables, as illustrated by numerical examples.
Cardiac mitochondrial complex activity is enhanced by heat shock proteins

1. Prolonged ischaemia and reperfusion in heart transplantation results in mitochondrial dysfunction and loss of cardio‐energetics. Improved myocardial tolerance to ischaemia–reperfusion can be increased by de novo synthesis of heat shock protein (Hsp) groups, transiently expressed following mild hyperthermic or oxidative stress. Consideration of the roles of various Hsp in ischaemic–reperfused myocardium can provide new insights into potential therapeutic adjuncts to cardiac surgery.
International Journal of Nanomedicine Dovepress Novel Formulation and Evaluation of a Q10-loaded Solid Lipid Nanoparticle Cream: in Vitro and in Vivo Studies

Solid lipid nanoparticles (SLNs) of coenzyme Q10 (CoQ10) were formulated by a high-pressure homogenization method. The best formulation of SLN dispersion consisted of 13% lipid (cetyl palmitate or stearic acid), 8% surfactant (Tween 80 or Tego Care 450), and water. Stability tests, particle size analysis, differential scanning calorimetry, transmission electron microscopy, and release study were conducted to find the best formulation. A simple cream of CoQ10 and a cream containing CoQ10-loaded SLNs were prepared and compared on volunteers aged 20–30 years. SLNs with particle size between 50 nm and100 nm exhibited the most suitable stability. In vitro release profiles of CoQ10 from simple cream, SLN alone, and CoQ10-loaded SLN cream showed prolonged release for SLNs compared with the simple cream, whereas there was no significant difference between SLN alone and SLN in cream. In vitro release studies also demonstrated that CoQ10-loaded SLN and SLN cream possessed a biphasic release pattern in comparison with simple cream. In vivo skin hydration and elasticity studies on 25 volunteers suggested good dermal penetration and useful activity of Q10 on skin as a hydratant and antiwrinkle cream.
Cardiopulmonary phenotype associated with human PHD2 mutation

Oxygen‐dependent regulation of the erythropoietin gene is mediated by the hypoxia‐inducible factor (HIF) family of transcription factors. When oxygen is plentiful, HIF undergoes hydroxylation by a family of oxygen‐dependent prolyl hydroxylase domain (PHD) proteins, promoting its association with the von Hippel‐Lindau (VHL) ubiquitin E3 ligase and subsequent proteosomal degradation. When oxygen is scarce, the PHD enzymes are inactivated, leading to HIF accumulation and upregulation not only of erythropoietin expression, but also the expression of hundreds of other genes, including those coordinating cardiovascular and ventilatory adaptation to hypoxia. Nevertheless, despite the identification of over 50 mutations in the PHD‐HIF‐VHL pathway in patients with previously unexplained congenital erythrocytosis, there are very few reports of associated cardiopulmonary abnormalities. We now report exaggerated pulmonary vascular and ventilatory responses to acute hypoxia in a 35‐year‐old man with erythrocytosis secondary to heterozygous mutation in PHD2, the most abundant of the PHD isoforms. We compare this phenotype with that reported in patients with the archetypal disorder of cellular oxygen sensing, Chuvash polycythemia, and discuss the possible clinical implications of our findings, particularly in the light of the emerging role for small molecule PHD inhibitors in clinical practice.
Politeness Strategies Used in the Exclusive Interview between Putra Nababan and Barack Obama, March 10, 2010 on RCTI

The title of this research is Politeness Strategies Used in the Exclusive Interview between Putra Nababan and Barack Obama, March 10, 2010 on RCTI. It is aimed at describing the politeness strategies used by Putra Nababan and Barack Obama, and describing the factors influencing the use of those strategies. The data were taken from the utterances by Putra Nababan and Barack Obama in the interview. It were classified based on politeness strategies by Brown and Levinson (1987). From the analysis, it can be concluded that in the interview between Putra Nababan and Barack Obama, there are four Politeness Strategies used. There are 86 utterances which consist of 39 utterances used by Putra Nababan and 47 utterances used by Barack Obama. There were 29 Bald on record strategies, 25 Positive politeness strategies, 31 Negative politeness strategies and 1 Off record strategy. From the analysis researcher found out that Putra Nababan used negative politeness more than other strategies, because Barack Obamas status and occupation is higher than him. And then, the factors influencing the use of strategies by Putra Nababan and Barack Obama, are occupation, social status and formality. Key Words: formality, interview, occupation, politeness strategies, social status.
The T4 Phage UvsW Protein Contains Both DNA Unwinding and Strand Annealing Activities*

UvsW protein belongs to the SF2 helicase family and is one of three helicases found in T4 phage. UvsW governs the transition from origin-dependent to origin-independent replication through the dissociation of R-loops located at the T4 origins of replication. Additionally, in vivo evidence indicates that UvsW plays a role in recombination-dependent replication and/or DNA repair. Here, the biochemical properties of UvsW helicase are described. UvsW is a 3′ to 5′ helicase that unwinds a wide variety of substrates, including those resembling stalled replication forks and recombination intermediates. UvsW also contains a potent single-strand DNA annealing activity that is enhanced by ATP hydrolysis but does not require it. The annealing activity is inhibited by the non-hydrolysable ATP analog (adenosine 5′-O-(thiotriphosphate)), T4 single-stranded DNA-binding protein (gp32), or a small 8.8-kDa polypeptide (UvsW.1). Fluorescence resonance energy transfer experiments indicate that UvsW and UvsW.1 form a complex, suggesting that the UvsW helicase may exist as a heterodimer in vivo. Fusion of UvsW and UvsW.1 results in a 68-kDa protein having nearly identical properties as the UvsW-UvsW.1 complex, indicating that the binding locus of UvsW.1 is close to the C terminus of UvsW. The biochemical properties of UvsW are similar to the RecQ protein family and suggest that the annealing activity of these helicases may also be modulated by protein-protein interactions. The dual activities of UvsW are well suited for the DNA repair pathways described for leading strand lesion bypass and synthesis-dependent strand annealing.
A Physically Meaningful Neural Network Behavioral Model for Wireless Transmitters Exhibiting PM–AM/PM–PM Distortions

Artificial neural networks (ANNs) have been widely used to model wireless transmitter low-pass equivalent behavior. However, previously proposed ANNs either do not account for PM-AM and PM-PM distortions or do not satisfy a fundamental constraint imposed by the bandpass nature of wireless transmitters. The purpose of this work is twofold. First, it is shown that PM-AM and PM-PM distortions observed in wireless transmitters excited by wideband signals can have a significant impact on the performance of their behavioral models. Second, a novel ANN topology for wireless transmitter behavioral modeling is proposed. Contrary to previously published ANNs, this one only generates physically meaningful contributions as well as retaining the ability of accounting for PM-AM and PM-PM distortions. The accuracy of the proposed ANN is then compared with two commonly used ANNs of the same computational complexity and for fitting experimental data measured on a GaN-based class-AB amplifier chain. Improvements of up to 7 dB in NMSE and ACEPR results are achieved if the proposed ANN is used instead of a commonly used ANN that neglects the PM-AM and PM-PM distortions. Furthermore, improvements as high as 16 dB in NMSE and ACEPR are achieved by the proposed ANN in comparison with a traditional ANN that also accounts for the PM-AM and PM-PM distortions but does not satisfy the fundamental odd-parity constraint imposed by the bandpass nature of wireless transmitters.
State-Based and Demographic Variation in Parent-Reported Medication Rates for Attention-Deficit/Hyperactivity Disorder, 2007–2008

Medication is the most effective treatment of attention-deficit/hyperactivity disorder (ADHD), a common neurobehavioral disorder of childhood. We used data from the 2007-2008 National Survey of Children’s Health to calculate weighted estimates of parent-reported ADHD and medication treatment among US children aged 4 to 17 years, by state and sex-stratified age. State-based rates of ADHD medication treatment ranged from 33% in Nevada to 79% in Mississippi; rates of medicated ADHD were higher among boys than girls at every age. State-based investigations of ADHD medication treatment factors are needed, and our findings may inform these public health efforts.
Semiquantitative bacterial observations with group B streptococcal vulvovaginitis.

OBJECTIVE: Group B streptococcal (GBS) vulvovaginitis is a poorly-delineated clinical entity. The purpose of this study is to report semiquantitative data from four cases of GBS vulvovaginitis and to comment on their significance in terms of the in vitro inhibitory capabilities of GBS. METHODOLOGY: Four patients whose clinical presentations were consistent with GBS vulvovaginitis, from whom GBS was isolated and for whom semi-quantitative as well as qualitative microbiologic data existed, were identified. RESULTS: To produce vulvovaginitis, GBS must be at a high multiplicity (10(8) CFU/g of vaginal fluid). Single coisolates were identified in three of the four cases (two cases of Escherichia coli and one case of Staphylococcus aureus). Group B streptococcus does not inhibit either of these bacteria in vitro. CONCLUSION: When the growth requirements for the demonstration of in vitro inhibition for GBS or lack thereof are met in vivo, the in vivo observations are consistent with those projected from the in vitro data.
Learning and Evaluation of the Approach Vector for Automatic Grasp Generation and Planning

In this paper, we address the problem of automatic grasp generation for robotic hands where experience and shape primitives are used in synergy so to provide a basis not only for grasp generation but also for a grasp evaluation process when the exact pose of the object is not available. One of the main challenges in automatic grasping is the choice of the object approach vector, which is dependent both on the object shape and pose as well as the grasp type. Using the proposed method, the approach vector is chosen not only based on the sensory input but also on experience that some approach vectors will provide useful tactile information that finally results in stable grasps. A methodology for developing and evaluating grasp controllers is presented where the focus lies on obtaining stable grasps under imperfect vision. The method is used in a teleoperation or a programming by demonstration setting where a human demonstrates to a robot how to grasp an object. The system first recognizes the object and grasp type which can then be used by the robot to perform the same action using a mapped version of the human grasping posture.
Évolution du gouvernement des entreprises:l'émergence de l'activisme actionnarial au milieu du XXe siècle

(VF)L'histoire de l'activisme actionnarial telle qu'on l'a racontee a donne aux premiers "contestataires" moins d'attention qu'ils ne le meritent. Non seulement ils etaient celebres a leur epoque, mais ils ont souleve des questions qui sont toujours d'actualite. Lorsque les questions de responsabilite et de gouvernement des entreprises ont refait surface dans les annees qui suivirent, les nouveaux activistes ont pu faire valoir les precedents etablis par ces pionniers. (gouvernement des entreprises - regulation publique - histoire economique - theorie actionnariale. (VA) Accounts of the history of shareholder activism have tended to give the early "gadflies" less attention than they deserve. Not only were they celebrated in their own time, they raised issues still relevant today. When issues of corporate governance and responsibility resurfaced in later years, the new activists would make use of the precedents set by these pioneers.
A Novel Differential Evolution with Uniform Design for Continuous Global Optimization

Differential Evolution (DE) is a simple and efficient optimizer, especially for continuous global optimization. Over the last few decades, DE has often been employed for solving various engineering problems. At the same time, the DE structure has some limitations in the complicated problems. This fact has inspired many researchers to improve on DE by proposing modifications to the original algorithm. Population initialization is very important to the performance of differential evolution. A good initialization method can help in finding better solutions and improving convergence rate. In this paper, a uniform-differential evolution algorithm (UDE) is proposed. It incorporates uniform design initialization method into differential evolution to accelerate its convergence speed and improve the stability. UDE is compared with other four algorithms of Standard Differential Evolution (SDE), Orthogonal Differential Evolution (ODE), Opposition Based Differential Evolution(OBDE) and Chaos Differential Evolution(CDE). Experiments have been conducted on 23 benchmark problems of diverse complexities. The results indicate that our approach has the stronger ability and higher calculation accuracy to find better solutions than other four algorithms.
Deciphering Protein–Protein Interactions. Part II. Computational Methods to Predict Protein and Domain Interaction Partners

Recent advances in high-throughput experimental methods for the identification of protein interactions have resulted in a large amount of diverse data that are somewhat incomplete and contradictory. As valuable as they are, such experimental approaches studying protein interactomes have certain limitations that can be complemented by the computational methods for predicting protein interactions. In this review we describe different approaches to predict protein interaction partners as well as highlight recent achievements in the prediction of specific domains mediating protein-protein interactions. We discuss the applicability of computational methods to different types of prediction problems and point out limitations common to all of them.
Architekturkonzepte für Rechnerkerne, Systeme und Kopplung

Einleitend wird der Begriff Rechnerarchitektur definiert. Eine Rechnerarchitektur wird verstanden als Vereinigung geeigneter Varianten der folgenden Grundkonzepte: Ablaufkontrolle, Speicherung und Darstellung von Information, Ein/Ausgabe und Struktur. Die verschiedenen Varianten dieser Grundkonzepte werden im Hauptteil des Beitrags beschrieben und diskutiert. Abschließend werden bekannte Architekturformen und ihre Repräsentanten unter Benutzung der vorgestellten Konzepte eingeordnet und charakterisiert.