Miracle-dz/UniFAR-FTUs huggingface dataset:
Measuring Affectiveness and Effectiveness in Software Systems

The summary presented in this paper highlights the results obtained in a four-years project aiming at analyzing the development process of software artifacts from two points of view: Effectiveness and Affectiveness. The first attribute is meant to analyze the productivity of the Open Source Communities by measuring the time required to resolve an issue, while the latter provides a novel approach for studying the development process by analyzing the affectiveness ex-pressed by developers in their comments posted during the issue resolution phase. Affectivenes is obtained by measuring Sentiment, Politeness and Emotions. All the study presented in this summary are based on Jira, one of the most used software repositories.
The Fluoroquinolone Finafloxacin Protects BALB/c Mice Against an Intranasal Infection With Francisella tularensis Strain SchuS4

The efficacy of the novel fluoroquinolone finafloxacin was evaluated as a potential therapeutic in vitro and in vivo, following an intranasal infection of Francisella tularensis strain SchuS4 in BALB/c mice. We demonstrated that short treatment courses of finafloxacin provide high levels of protection, with a single dose resulting in a significant increase in time to death when compared to ciprofloxacin. In addition, following investigation into the window of opportunity for treatment, we have shown that finafloxacin can provided protection when administered up to 96 h post-challenge. This is particularly encouraging since mice displayed severe signs of disease at this time point. In summary, finafloxacin may be a promising therapy for use in the event of exposure to F. tularensis, perhaps enabling the treatment regimen to be shortened or if therapy is delayed. The efficacy of finafloxacin against other biological threat agents also warrants investigation.
Cosmological Density Perturbations from a Quantum Gravitational Model of Inflation

We derive the implications for anisotropies in the cosmic microwave background following from a model of inflation in which a bare cosmological constant is gradually screened by an infrared process in quantum gravity. The model predicts that the amplitude of scalar perturbations is $A_S = (2.0 \pm .2) \times 10^{-5}$, that the tensor-to-scalar ratio is $r \approx 1.7 \times 10^{-3}$, and that the scalar and tensor spectral indices are $n \approx . 97$ and $n_T \approx -2.8 \times 10^{-4}$, respectively. By comparing the model's power spectrum with the COBE 4-year RMS quadrupole, the mass scale of inflation is determined to be $M = (.72 \pm .03) \times 10^{16}~{\rm GeV}$. At this scale the model produces about $10^8$ e-foldings of inflation, so another prediction is $\Omega = 1$.
Reasoning with Contextual Data in Telehealth Applications

The notion of context-awareness is making its way in the area of mobile-health application designed to assist patients outside a hospital and medical professionals within a hospital. Such ubiquitous computing applications go beyond simple biomedical data-collection so the management of the context becomes more challenging, and the complexity of the context-based decision-algorithms warrants the use of full-blown inference engines. The context is a very volatile notion, so building a context-aware system means more than just creating a context ontology and defining inference rules for that model. This paper proposes mechanisms to dynamically manage the contextual decisions and actions. It devises a model and its properties for the process of taking each individual context-based decision. An architecture centered around this model is defined, integrating an off-the-shelf inference engine that reasons on context-data expressed in the OWL language. The architecture was refined and validated through the implementation of a prototype remote biomonitoring system. The prototype combines context-adaptation and awareness with the ubiquity of 3G network-coverage to allow for more personalized monitoring and better streamlining of information between the various health care players. It can be easily adapted and extended with extra inference-rules, additional actions, and more context items.
Clinical Outcomes of Patients with Delayed Diagnosis of Spinal Dural Arteriovenous Fistulas

BACKGROUND AND PURPOSE: Spinal dural arteriovenous fistulas are commonly missed on imaging or misdiagnosed as inflammatory or neoplastic processes. We reviewed a consecutive series of spinal dural arteriovenous fistulas referred to our institution that were missed or misdiagnosed on initial imaging and studied the clinical consequences of missing or misdiagnosing the lesion. MATERIALS AND METHODS: We reviewed spinal dural arteriovenous fistulas diagnosed at our institution between January 1, 2000, and November 1, 2014. A lesion was defined as “misdiagnosed” if initial MR imaging or CT myelography demonstrated characteristic imaging features of spinal dural arteriovenous fistula but the patient was clinically or radiologically misdiagnosed. Outcomes included length of delay of diagnosis, increased disability (increase in mRS or Aminoff motor disability of ≥1 point) between initial imaging evaluation and diagnosis date, and posttreatment disability. RESULTS: Fifty-three consecutive spinal dural arteriovenous fistulas that were initially misdiagnosed despite having characteristic imaging findings on MR imaging or CT myelography were included in our study. Eight patients (18.9%) underwent spinal angiography before referral, which was interpreted as having negative findings but was either incomplete (6 cases) or retrospectively demonstrated the spinal dural arteriovenous fistulas (2 cases). The median time of delayed diagnosis was 6 months (interquartile range, 2–14 months). Fifty-one patients (96.2%) had increased disability between the initial study, which demonstrated features of a spinal dural arteriovenous fistula, and diagnosis. Thirty-two patients (60.4%) developed a new requirement for a walker or wheelchair. Following treatment, 21 patients (41.2%) had an improvement of 1 point on the mRS or Aminoff motor disability scale. CONCLUSIONS: Delayed diagnosis of spinal dural arteriovenous fistula with characteristic imaging features results in high rates of additional disability that are often irreversible despite surgical or endovascular treatment of the fistula.
Adaptación del Método de Etiquetado No Supervisado TBL

espanolSe presenta una mejora al metodo de etiquetado de Brill basado en reglas y transformaciones. Se disminuye considerablemente los tiempos de entrenamiento sin sacrificar de ninguna manera la eficicacia del metodo. EnglishThis paper proposes an improvement of the Brill's "Transformation-Rule Based" POS-Tagger Algorithm. Our improvement decreases training times considerably without affecting the accuracy of the algorithm.
Physiological Measurements in Phobic and Obsessional Disorders

The various physiological measurements which can be made in obsessional and phobic disorders are described. Useful information can be obtained about the effects of acute stress and the changes that medication can produce in anxious patients and the clinical progress of behaviour therapy can be monitored. When physiological measurements are made it is important to record the emotional state of the patient simultaneously so that the level of physiological arousal is related to the subjective experience of the patient.
Mortalité des hommes et des femmes dans le passé

According to Ashley Montagu, females have a more sturdy constitution than males. Edward Shorter defends another argument : prior to the medical progress of this century, woman's health, from the end of infancy to around age 45, was precarious ; added to the risks related to pregnancy and childbirth, this made her prone to early death. To throw light on the true pattem of female mortality in the past, this paper examines statistics for girls and adolescents on one hand and women of childbearing age on the other. For the latter, maternal mortality was apparently the only cause of excess female mortality. For girls and adolescents, the oldest observations suggest that excess female mortality did not always exist for these age-groups, but the fact that the medical and other progress made was initially of less benefit to girls than boys still requires explanation.
Anti-thyroidal peroxidase antibodies are associated with thyrotropin levels in hypothyroid patients and in euthyroid individuals.

OBJECTIVE The study was designed to evaluate the relationship between thyroid antibodies and gland dysfunction, with the aim of finding a clinically useful threshold value of thyreoperoxidase antibodies, which could prove to be predictive for thyroid failure. MATERIAL AND METHODS The study was conducted on 99 women, ages ranging from 18-91 years (mean age: 45.5 ±17.0), were treated as outpatients in the Department of Endocrinology, Metabolism and Internal Medicine. Analysis of serum samples for TSH concentration and anti-TPO titers was conducted. RESULTS The most common disorder was hypothyroidism. Anti-TPO titers above reference range values were observed in 35 patients (35.4%): 21 (60%) were hypothyroid and 11 (31.4 %) were euthyroid. The anti-TPO and TSH serum levels correlated both in patients with high thyroid antibody titers, and in the anti-TPO negative groups. To find the threshold value of anti- TPO that would help predict hypothyroidism, receiver operating curves were used. With this approach, TPO antibody titers over 17 IU/ml indicated hypothyroidism with a 90% sensitivity and 75% sensibility. CONCLUSIONS It can be postulated that the cutoff values of anti-TPO in the general population should be decreased in order to improve autoimmune thyroid disorder screening. Obviously, using that margin may lead initially to the detection of some false positive subjects. However, with lower cut-off values, more patients can be enrolled into thyroid follow-up groups. In this way, many people could avoid complications of undiagnosed, insidious thyroid failure.
Thrombospondin-1 as a Paradigm for the Development of Antiangiogenic Agents Endowed with Multiple Mechanisms of Action

Uncontrolled neovascularization occurs in several angiogenesis-dependent diseases, including cancer. Neovascularization is tightly controlled by the balance between angiogenic growth factors and antiangiogenic agents. The various natural angiogenesis inhibitors identified so far affect neovascularization by different mechanisms of action. Thrombospondin-1 (TSP-1) is a matricellular modular glycoprotein that acts as a powerful endogenous inhibitor of angiogenesis. It acts both indirectly, by sequestering angiogenic growth factors and effectors in the extracellular environment, and directly, by inducing an antiangiogenic program in endothelial cells following engagement of specific receptors including CD36, CD47, integrins and proteoglycans (all involved in angiogenesis ). In view of its central, multifaceted role in angiogenesis, TSP-1 has served as a source of antiangiogenic tools, including TSP-1 fragments, synthetic peptides and peptidomimetics, gene therapy strategies, and agents that up-regulate TSP-1 expression. This review discusses TSP-1-based inhibitors of angiogenesis, their mechanisms of action and therapeutic potential, drawing our experience with angiogenic growth factor-interacting TSP-1 peptides, and the possibility of exploiting them to design novel antiangiogenic agents.
Window Watcher: a visualisation tool for understanding windowing activities

Almost all actions on a computer are mediated by windows, yet we know surprisingly little about how people coordinate their activities using these windows. Studies of window use are difficult for two reasons: gathering longitudinal data is problematic and it is unclear how to extract meaningful characterisations from the data. In this paper, we present a visualisation tool called Window Watcher that helps researchers understand and interpret low level event logs of window switching activities generated by our tool PyLogger. We describe its design objectives and demonstrate ways that it summarises and elucidates window use.
Playing Blind: Revealing the World of Gamers with Visual Impairment

Previous research on games for people with visual impairment (PVI) has focused on co-designing or evaluating specific games - mostly under controlled conditions. In this research, we follow a game-agnostic, "in-the-wild" approach, investigating the habits, opinions and concerns of PVI regarding digital games. To explore these issues, we conducted an online survey and follow-up interviews with gamers with VI (GVI). Dominant themes from our analysis include the particular appeal of digital games to GVI, the importance of social trajectories and histories of gameplay, the need to balance complexity and accessibility in both games targeted to PVI and mainstream games, opinions about the state of the gaming industry, and accessibility concerns around new and emerging technologies such as VR and AR. Our study gives voice to an underrepresented group in the gaming community. Understanding the practices, experiences and motivations of GVI provides a valuable foundation for informing development of more inclusive games.
A Distributed Architecture for Certificate-Based Delegation of Business Process Accessibility in Virtual Organizations

In this paper, a distributed architecture has been proposed in order to support an authorization service more precisely in dynamically created Virtual Organizations (VO). In comparison to other existing architectures such as Akenti, VOMS and TAS, our architecture uses certificates on top a of the distributed agent architecture for managing requested resources among the VOs. The most obscure issue in distributed agents is finding the proper node that keeps the particular requested certificates In this paper, Chord’s Finger Table has been improved to add extra search abilities on the ring architecture of Chord. The process of locating keys can be implemented on the top of the improved Chord by associating a key with each data item, and storing the key/data item pair at the node to which the key maps. In this article, a theatrical analysis is presented for simulations, which shows improvement in the number of passed hops to locate keys in the proposed method in comparison of standard chord, so it’s more cost efficient.
Molecular Anatomy of the Hair Cell's Ribbon Synapse

Hearing depends on reliable and temporally precise neurotransmission by cochlear hair cells. The wide dynamic range and high sensitivity with which these cells encode acoustic stimuli are associated with a presynaptic specialization termed the presynaptic dense body or synaptic ribbon. Apposed to the presynaptic density, this spherical or flattened structure tethers a layer of synaptic vesicles and is thought to facilitate their exocytotic fusion. Although defining the molecular constituents of the hair cell's synaptic ribbon should contribute to our understanding of neurotransmitter release at this synapse, accomplishing this task has been slowed by the difficulty of obtaining sufficient amounts of starting material for protein analysis from hair cells. We isolated synaptic material from chicken cochleas, purified synaptic ribbons with specific immunological reagents, and identified the associated proteins by tandem mass spectrometry. Purification of the ribbons revealed a predominant composition of C-terminal-binding proteins, especially ribeye, in association with the small GTPase Rab3, which is possibly involved in attaching vesicles to the ribbon. In comparison with the components of conventional synapses and of retinal ribbon synapses, we observed that certain regulatory proteins are excluded from the hair cell's synapse. Using antisera against several of the novel proteins and membrane-trafficking components that we had identified, we documented their localization in isolated hair cells. Our results indicate that the ribbon synapses of hair cells display modifications to the presynaptic machinery that are associated with the high-fidelity transmission of acoustic signals to the brain.
Detecting Thermal Emotional Profile

Human can react emotionally to specific situations provoking some physiological changes that can be detected using a variety of devices, facial expression, electrodermal activity, and EEG systems are among the efficient devices which can assess the emotional reactions. However, emotions can trigger some small changes in blood flow with an impact on skin temperature. In the present research we use EEG and a thermal camera to determine the emotional profile of a user submitted to a set of emotional pictures. Six experiments were performed to study the thermal reactions to emotions, and in each experiment, 80 selected standard stimuli pictures of 20 various emotional profiles from IAPS (a database of emotional images) were displayed to participants every three seconds. An infrared camera and EEG were used to capture both thermal pictures of participants and their electrical brain activities. We used several area of the face to train a classifier for emotion recognition using Machine Learning models. Results indicate that some specific areas are more significant than others to show a change in temperature. These changes are also slower than with the EEG signal. Two methods were used to train the HMM, one is training classifier per the participant self data (participantindependent), another is training classifier based on all participants` thermal data (participant-dependent). The result showed the later method brings more accuracy emotion recognition.
Identification of IgG subclasses and C-reactive protein in lupus nephritis: the relationship between the composition of immune deposits and FCgamma receptor type IIA alleles.

OBJECTIVE To characterize the subclass composition of IgG deposited in lupus glomeruli, to examine its relationship to allelic polymorphisms of IgG receptors (Fcgamma receptors [FcgammaR]), and to determine whether C-reactive protein (CRP), a ligand for FcgammaRIIa, is present in these immune deposits. METHODS Renal biopsy samples from 80 patients with lupus nephritis were examined by light microscopy and indirect immunofluorescence with IgG-subclass-specific monoclonal antibodies. FcgammaRIIA genotypes were determined using allele-specific polymerase chain reaction. Immunostaining for CRP was performed on lupus and nonlupus glomerulonephritis specimens. RESULTS IgG2 and IgG3 were the predominant subclasses in immune deposits in all World Health Organization classes of nephritis. The frequency of genotypes containing the low-binding IgG2 allele, FcgammaRIIa-R131, was significantly greater than expected in patients with class III or class IV nephritis and in patients with intense IgG2 deposition. CRP, a ligand with particular affinity for FcgammaRIIa-R131, was consistently present in the renal immune deposits of lupus nephritis specimens. CONCLUSION FcgammaRIIA genes are associated with proliferative renal disease and may contribute to disease pathogenesis. FcgammaRIIa-R131, the variant with low affinity for IgG2, has high affinity for CRP. Thus, FcgammaRIIa-R131 may contribute to impaired removal of circulating immune complexes, as well as efficiently triggering phagocyte activation and the release of inflammatory mediators within glomeruli.
The effect of the decline in institutionalized religion on suicide, 1954-1978.

While there has been much discussion of the decline in institutionalized religion in recent decades, there has been little work on the consequences of such a decline. This study adopts a social integration/regulation perspective that predicts a rise in suicide from the decline in institutionalized religion. Using Cochrane-Orcutt iterative regression procedures, the investigation links the decline of religion, measured in church attendance, with a rise in suicide. The religious factor tends to be more closely associated with suicide than the rate of unemployment, a control taken from one of the dominant paradigms on suicide. The decline in religion was most closely associated with the suicide rate of young adults, the group with the greatest decline in church attendance. To 1978, the analysis suggests that any alleged increase in "invisible religion" had not been adequate to offset the effect of the fall in institutionalized religion on suicide. While the fall in church attendance was the most important factor associated with rising suicide rates, the rate of unemployment and military participation were also significant.
Prevalence of vero toxic Escherichia coli in fecal samples of domestic as well as wild ruminants in Mathura districts and Kanpur zoo

Aim: The present study was planned to reveal the prevalence of verocytotoxigenic Escherichia coli (VTEC) in fecal samples of domestic and wild ruminants in Mathura district and Kanpur zoo. Materials and Methods: A total of 240 fecal samples comprising 60 each of cattle, buffalo, sheep and deer from Mathura districts and Kanpur zoo were screened for the presence of E. coli and VTEC genes positive by polymerase chain reaction (PCR). Result: Out of 240 fecal samples, 212 E. coli strains were obtained. All the E. coli isolates were screened by PCR to detect virulence genes stx1, stx2, eaeA and hlyA. Of these, 25 isolates were identified as VTEC. The prevalence of VTEC in cattle, buffalo, sheep and deer was found 13.4% (8/60), 13.4% (8/60), 6.67% (4/60) and 8.33% (5/60), respectively. Conclusion: stx1, stx2, eaeA and hlyA genes were prevalent in VTEC isolates from feces of cattle, buffalo, sheep and deer population of Mathura districts and Kanpur zoo. The presence of VTEC isolates in this region may pose a threat to public health.
The Challenges of Flight-Testing Unmanned Air Vehicles

Unmanned Air Vehicles (UAVs) remain a developing technology of keen interest to the military as well as certain commercial enterprises (such as mining exploration companies), with over 200 UAV types in use throughout the world. UAVs present a difficult challenge for the T&E community as well, with present military UAV interest focussed on total autonomy to reduce operator skill requirements and increase the reliability of tactical systems. This paper postulates that there is an optimum level of ‘man-in-the-loop’ air vehicle control, as opposed to totally autonomous operation to conduct particular missions. Although it may be desirable to operate autonomously, practical constraints may enforce a requirement to adopt a level of manual control to ensure navigation and altitude control functions, initiate in-flight emergency procedures and maintain traffic separation (particularly in civil airspace), all of which need to be tested as part of the system package. The authors argue the UAV mission and payload should determine the requirements for autonomy and these will directly affect the conduct of the T&E. The thrust of this paper is that a systems approach is necessary when developing the UAV system and planning its T&E programme. Discussion points in this paper draw on the authors’ experiences in a current project developing a UAV for an Australian mining exploration firm.