Miracle-dz/UniFAR-FTUs huggingface dataset:
Phosphorylation potential of Drosophila E-Cadherin intracellular domain is essential for development and adherens junction biosynthetic dynamics regulation

Phosphorylation of a highly conserved serine cluster in the intracellular domain of E-Cadherin is essential for binding to β-Catenin in vitro. In cultured cells, phosphorylation of specific serine residues within the cluster is also required for regulation of adherens junction (AJ) stability and dynamics. However, much less is known about how such phosphorylation of E-Cadherin regulates AJ formation and dynamics in vivo. In this report, we generated an extensive array of Drosophila E-Cadherin (DE-Cad) endogenous knock-in alleles that carry mutations targeting this highly conserved serine cluster. Analyses of these mutations suggest that the overall phosphorylation potential, rather than the potential site-specific phosphorylation, of the serine cluster enhances the recruitment of β-Catenin by DE-Cad in vivo. Moreover, phosphorylation potential of the serine cluster only moderately increases the level of β-Catenin in AJs and is in fact dispensable for AJ formation in vivo. Nonetheless, phosphorylation-dependent recruitment of β-Catenin is essential for development, probably by enhancing the interactions between DE-Cad and α-Catenin. In addition, several phospho-mutations dramatically reduced the biosynthetic turnover rate of DE-Cad during apical-basal polarization, and such biosynthetically stable DE-Cad mutants specifically rescued the polarity defects in embryonic epithelia lacking the polarity proteins Stardust and Crumbs. Summary: Phosphorylations of the conserved serine cluster in the Drosophila E-Cadherin intracellular tail are quantitatively rather than site specifically required for its function in adherens junction formation.
Blind estimation of residual carrier offset in OFDM systems

In orthogonal frequency division multiplexing (OFDM) systems, the loss of orthogonality between the subcarriers due to carrier offset can degrade the performance of the system. In the literature, Liu and Tureli proposed a blind, music-like method to solve such a problem. The latter has a good performance as compared to the Cramer-Rao bound, but can have a very high computational complexity. In this letter, based on practical considerations, we present a new implementation of the previous method that reduces significantly the cost without sacrificing the performance.
Impact of Limited Feedback on Multiple Relay Zero-Forcing Precoding Systems

In recent literature, it has been shown that in a relaying network utilizing multiple relay precoding, the signal-to- noise ratio (SNR) at each destination node will scale linearly with the number of relays K, which is referred to as the distributed array gain (DAG) K. Different from the prior studies which assume perfect channel state information (CSI) at each of the relay nodes, this work considers the impact of limited feedback on the performance of multiple relay precoding. We show that the conventional limited feedback scheme fails to obtain the DAG K, which is due to the phase ambiguity introduced by the channel quantization function. Based on the analysis, a novel feedback and precoding procedure is proposed. It is proved that the proposed procedure can obtain the DAG K with only one additional feedback bit for quantizing each relay-destination channel compared with the conventional scheme. Simulation results are also provided to verify our analysis.
Analysis of the reference coordinate system used in the EKF-based SLAM

In this paper we analyze the differences in the EKF-SLAM frameworks that are constructed using different coordinate system. First, we derive the EKF equations in the world coordinate system through modification of the EKF equations in the robot coordinate system. When the reference coordinate system is changed, the equations change due to its nonlinear behavior. We identify four EKF-SLAM frameworks, and then we demonstrate that any framework can be used in EKF-SLAM by simulation and real-life experiments.
Multi-View Clustering with Web and Linguistic Features for Relation Extraction

Binary semantic relation extraction is particularly useful for various NLP and Web applications. Currently Web-based methods and Linguistic-based methods are two types of leading methods for semantic relation extraction task. With a novel view on integrating linguistic analysis on local text with Web frequent information, we propose a multi-view co-clustering approach for semantic relation extraction. One is feature clustering by automatically learning clustering functions for Web features, linguistic features simultaneously based on a subset of entity pairs. The other is relation clustering, using the feature clustering functions to define learning function for relation extraction. Our experiments demonstrate the superiority of our clustering approach comparing with several state-of-the-art clustering methods.
Experimental and thermodynamic evaluation of the Co–Cr–C system

Abstract New experimental results on the liquid+graphite+M7C3 equilibrium are presented. The solubility of Co in the M7C3 carbide has been measured at 1523 and 1723K. These measurements together with recently published measurements on the fcc+graphite+M7C3 equilibrium show that the solubility of Co in the M7C3 is much higher than predicted from thermodynamic calculations. A new thermodynamic description of the Co–Cr–C system is presented which accurately describes the solubility of Co in the M7C3 carbide in the temperature range 1373–1723K.
A Monoclonal Antibody to Histoplasma capsulatum Alters the Intracellular Fate of the Fungus in Murine Macrophages

ABSTRACT Monoclonal antibodies (MAbs) to a cell surface histone on Histoplasma capsulatum modify murine infection and decrease the growth of H. capsulatum within macrophages. Without the MAbs, H. capsulatum survives within macrophages by modifying the intraphagosomal environment. In the present study, we aimed to analyze the affects of a MAb on macrophage phagosomes. Using transmission electron and fluorescence microscopy, we showed that phagosome activation and maturation are significantly greater when H. capsulatum yeast are opsonized with MAb. The MAb reduced the ability of the organism to regulate the phagosomal pH. Additionally, increased antigen processing and reduced negative costimulation occur in macrophages that phagocytose yeast cells opsonized with MAb, resulting in more-efficient T-cell activation. The MAb alters the intracellular fate of H. capsulatum by affecting the ability of the fungus to regulate the milieu of the phagosome.
Sound and Static Analysis of Session Fixation Vulnerabilities in PHP Web Applications

Web applications use authentication mechanisms to provide user-friendly content to users. However, some dangerous techniques like session fixation attacks target these mechanisms, by making the legitimate user use a session identifier that is controlled by the attacker. In this way, he can then impersonate the legitimate user without the need to know his credentials. In this paper, we present SAWFIX, a PHP static analyzer that checks web applications for session fixation vulnerabilities. To the best of our knowledge, SAWFIX is the first analyzer that checks exhaustively for this type of vulnerabilities, while the other methods only ensure partial correctness that is limited to a fraction of possible executions. SAWFIX is based on abstract interpretation, which is a theory for approximating the semantics of programs and allows designing static analyzers that are fully automatic and sound by construction. We implemented a prototype of our approach and tested it on several complex web applications. We obtained promising results in terms of detection accuracy and processing time, which reflects the efficiency of our system.
Quantifying the Relationship Between Peel and Rheology for Pressure Sensitive Adhesives

An attempt is made in this work to model quantitatively the peel force vs. rate behavior of a pressure sensitive adhesive (PSA) tape. The approach follows suggestions of previous authors in modeling the deformation of the PSA as uniaxial extension of individual strands. A debonding failure criterion based on stored elastic energy density is used. In this work, experimental measurements of dynamic mechanical master curves are used to provide the mechanical properties of the PSA in the model. The predictions are compared with experimental peel force vs. rate master curves on tapes made from those same adhesives. The only adjustable parameter for the fitting is the quantity related to the debonding criterion. In this set of natural-rubber-based PSAs, the general shape of the peel master curve and the changes in peel behavior associated with tackifier loading and rubber molecular weight are well explained by the model. The effect of changes in substrate chemistry are not well explained.
Bounds on the accuracy of estimating the parameters of discrete homogeneous random fields with mixed spectral distributions

This paper considers the achievable accuracy in jointly estimating the parameters of a real-valued two-dimensional (2-D) homogeneous random field with mixed spectral distribution, from a single observed realization of it. On the basis of a 2-D Wold-like decomposition, the field is represented as a sum of mutually orthogonal components of three types: purely indeterministic, harmonic, and evanescent. An exact form of the Cramer-Rao lower bound on the error variance in jointly estimating the parameters of the different components is derived. It is shown that the estimation of the harmonic component is decoupled from that of the purely indeterministic and the evanescent components. Moreover, the bound on the parameters of the purely indeterministic and the evanescent components is independent of the harmonic component. Numerical evaluation of the bounds provides some insight into the effects of various parameters on the achievable estimation accuracy.
Community-based Collaborative Filtering Recommendation Algorithm

Collaborative filtering recommendation technology is by far the most widely used and successful personalized recommendation technology. However, the method currently faced with some problems such as sparse matrix, affecting the accuracy of the predicted results. This paper puts forward a new community detection algorithm based on topological potential theory, and combines it with collaborative filtering recommendation algorithm. The users with similar interests are put into the same community. When searching for the user’s nearest neighbor, it target to the users in a specific community or several communities instead of all users, which narrows the search and improves the prediction accuracy. Experimental results suggest that this approach effectively reduces the impact on the prediction accuracy of the sparse matrix, and significantly improves the prediction ability and recommendation quality.
Semantic clustering in verbal fluency: schizophrenic patients versus control participants

Background. Schizophrenic patients generate fewer words than healthy controls during verbal fluency tasks. The structure of output may explain why patients generate fewer exemplars. Methods. Twenty-four healthy controls and 24 patients with schizophrenia participated in six, 3 min semantic fluency tasks. In a subsequent session, participants were given cards, each printed with one of their own words generated from previous fluency tasks. Participants were to sort the cards into categories (e.g. subcategories of ‘animals’), thus defining their own semantic subcategories of words, and thereby eliminating experimenter assumptions about word relatedness. These clusters were matched with fluency output of each participant. The time spent searching through semantic networks within clusters and switching to other clusters when locating and producing associated words were measured. Results. Patients produced fewer words and spent more time switching to words within clusters and to different clusters than controls, but otherwise response profiles were similar. Although controls returned more frequently to clusters and consequently made more switches between these clusters than patients, this group difference disappeared when the total number of words produced was covaried. Conclusions. Consistent with previous literature, patients produced fewer words and made more errors than controls. The absence of a group difference in number of different clusters or mean number of items per cluster suggests that patients are similar to controls with respect to number of ideas in their semantic network. Patients' longer between-cluster switching times indicate a general slowness that may be attributed to difficulties finding new words within a semantic field.
Effect and Stability of Poly(Amido Amine)-Induced Biomineralization on Dentinal Tubule Occlusion

In recent years, scientists have developed various biomaterials to remineralize human teeth to treat dentine hypersensitivity. Poly(amido amine) (PAMAM) dendrimers have become a research focus in this field. It has been demonstrated that PAMAM is able to create precipitates both on the surface of and within the dentinal tubules, however, there is little information about its effect on reducing dentine permeability in vitro. This study aimed to evaluate the in vitro effectiveness and stability of the fourth generation amine-terminated PAMAM on dentinal tubule occlusion, especially on dentine permeability. Sodium fluoride (NaF), which has been widely used as a desensitizing agent, is regarded as positive control. Demineralized sensitive dentine samples were coated with PAMAM or sodium fluoride solutions and soaked in artificial saliva (AS) at 37 °C for different periods. Four weeks later, samples in each group were then equally split into two subgroups for testing using a brushing challenge and an acid challenge. Dentine permeability of each specimen was measured before and after each challenge using a fluid filtration system. Dentine morphology and surface deposits were characterized by scanning electron microscope (SEM) and analyzed with Image-Pro Plus software. Data were evaluated through multifactorial ANOVA with repeated measures and pair-wise comparisons at a level of 5%. The results showed that PAMAM and NaF significantly reduced dentine permeability to 25.1% and 20.7%. Both of them created precipitates on dentine surfaces after AS immersion for 28 days. PAMAM-induced biomineralization not only on dentine surfaces, but also deeper in dentinal tubules, significantly reduced dentine permeability. Moreover, PAMAM-induced biomineralization elicited excellent stable occlusion effects after acid challenge. In conclusion, PAMAM demonstrated a strong ability to resist acid and showed great potential to be used in the treatment of dentine hypersensitivity in future.
Implementation of a neural network tracking controller for a single flexible link: comparison with PD and PID controllers

The objective of this paper is to show the results of the practical implementation of a neural network (NN) tracking controller on a single flexible link and compare its performance to that of proportional derivative (PD) and proportional integral derivative (PID) standard controllers. The NN controller is composed of an outer PD tracking loop, a singular perturbation inner loop for stabilization of the fast flexible-mode dynamics, and an NN inner loop used to feedback linearize the slow pointing dynamics. No off-line training or learning is needed for the NN. It is shown that the tracking performance of the NN controller is far better than that of the PD or PID standard controllers. An extra friction term was added in the tests to demonstrate the ability of the NN to learn unmodeled nonlinear dynamics.
Prevalence of obstructive lung disease in a general population: relation to occupational title and exposure to some airborne agents.

BACKGROUND: The importance of occupational exposure to airborne agents in the development of obstructive disease is uncertain. Studying the relation in a community population has the benefit of reducing the healthy worker effect seen in studies of working populations. METHODS: The prevalence of obstructive lung disease was examined in a Norwegian general population aged 18-73 in a two phased cross sectional survey. In the second phase a stratified sample (n = 1512) of those responding in the first phase was invited for clinical and spirometric examination (attendance rate 84%). Attenders were asked to state all jobs lasting greater than 6 months since leaving school and to say whether they had been exposed to any of seven specific agents and work processes potentially harmful to the lungs. RESULTS: The prevalence of asthma and chronic obstructive lung disease was 2.4% and 5.4%, respectively; spirometric airflow limitation (FEV1/FVC less than 0.7 and FEV1 less than 80% of predicted values) was observed in 4.5% of the population. All jobs were categorised into three groups according to the degree of potential airborne exposure. Having a job with a high degree of airborne exposure increased the sex, age, and smoking adjusted odds ratio for obstructive lung disease (asthma and chronic obstructive lung disease) by 3.6 (95% confidence interval 1.3 to 9.9) compared with having a job without airborne exposure; the association with spirometric airflow limitation was 1.4 (0.3 to 5.2). Occupational exposures to quartz, metal gases, aluminium production and processing, and welding were significantly associated with obstructive lung disease after adjusting for sex, age, and smoking habit, the adjusted odds ratios varying between 2.3 and 2.7. Occupational exposure to quartz and asbestos was significantly related to spirometric airflow limitation in people older than 50. CONCLUSION: Occupational title and exposure to specific agents and work processes may be independent markers of obstructive lung disease in the general population.
Prospective evaluation of 2,549 Morse taper connection implants: 1- to 6-year data.

BACKGROUND The aim of this study is to evaluate the implant survival, the implant-crown success, and the prosthetic complications of 2,549 Morse taper interference-fit connection implants. METHODS A total of 2,549 Morse taper connection implants were inserted in 893 patients from January 2003 until December 2008. At each annual recall, clinical, radiographic, and prosthetic parameters were assessed. The implant-crown success criteria included the absence of pain, suppuration, and clinical mobility; an average distance between the implant shoulder and the first visible bone contact <2 mm from initial surgery; and the absence of prosthetic complications at the implant-abutment interface. Prosthetic restorations were fixed partial prostheses (462 units); fixed full-arch prostheses (60 units); single crowns (531 units); and overdentures (93 units). RESULTS The cumulative implant survival rate was 98.23% (97.25% maxilla, 99.05% mandible). The implant-crown success was 92.49%. A few prosthetic complications at implant-abutment interface were reported (0.37%). After 6 years, distance between the implant shoulder and the first visible bone contact was 1.10 mm (± 0.30 mm). CONCLUSION The use of Morse taper connection implants represents a successful procedure for the rehabilitation of partially and completely edentulous arches.
Kinetic Energy Decay Rates of Supersonic and Super-Alfvénic Turbulence in Star-Forming Clouds

We compute 3D models of supersonic, sub-Alfvenic, and super-Alfvenic decaying turbulence, with an isothermal equation of state appropriate for star-forming interstellar clouds of molecular gas. We find that in 3D the kinetic energy decays as t-? , with 0.85 < ? < 1.2. In ID magnetized turbulence actually decays faster than unmagnetized turbulence. We compared different algorithms, and performed resolution studies reaching 2563 zones or 703 particles. External driving must produce the observed long lifetimes and supersonic motions in molecular clouds, as undriven turbulence decays too fast.
Cohort profile Cohort Profile : The ONtario Population Health and Environment Cohort ( ONPHEC )

Cohort Profile: The ONtario Population Health and Environment Cohort (ONPHEC) Hong Chen*, Jeffrey C. Kwong, Ray Copes, Paul J. Villeneuve, Mark S. Goldberg, Scott Weichenthal, Aaron van Donkelaar, Michael Jerrett, Randall V. Martin, Jeffrey R. Brook, Alexander Kopp and Richard T. Burnett Public Health Ontario, Toronto, ON, Canada, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, Institute for Clinical Evaluative Sciences, Toronto, ON, Canada, Department of Family and Community Medicine, University of Toronto, Toronto, ON, Canada, CHAIM Research Centre, Carleton University, Ottawa, ON, Canada, Department of Medicine, McGill University, Montreal, QC, Canada, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada, Air Health Effects Science Division, Health Canada, Ottawa, ON, Canada, Department of Physics and Atmospheric Science, Dalhousie University, Halifax, NS, Canada, Department of Environmental Health Sciences, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, CA, USA, Harvard-Smithsonian Centre for Astrophysics, Cambridge, MA, USA, Air Quality Research Division, Environment Canada, Toronto, ON, Canada and Population Studies Division, Health Canada, Ottawa, ON, Canada
Alternative Splicing Controlled by Heterogeneous Nuclear Ribonucleoprotein L Regulates Development, Proliferation, and Migration of Thymic Pre-T Cells

The regulation of posttranscriptional modifications of pre-mRNA by alternative splicing is important for cellular function, development, and immunity. The receptor tyrosine phosphatase CD45, which is expressed on all hematopoietic cells, is known for its role in the development and activation of T cells. CD45 is known to be alternatively spliced, a process that is partially regulated by heterogeneous nuclear ribonucleoprotein (hnRNP) L. To investigate the role of hnRNP L further, we have generated conditional hnRNP L knockout mice and found that LckCre-mediated deletion of hnRNP L results in a decreased thymic cellularity caused by a partial block at the transition stage between double-negative 4 and double-positive cells. In addition, hnRNP L−/− thymocytes express aberrant levels of the CD45RA splice isoforms and show high levels of phosphorylated Lck at the activator tyrosine Y394, but lack phosphorylation of the inhibitory tyrosine Y505. This indicated an increased basal Lck activity and correlated with higher proliferation rates of double-negative 4 cells in hnRNP L−/− mice. Deletion of hnRNP L also blocked the migration and egress of single-positive thymocytes to peripheral lymphoid organs in response to sphingosine-1-phosphate and the chemokines CCL21 and CXCL12 very likely as a result of aberrant splicing of genes encoding GTPase regulators and proteins affecting cytoskeletal organization. Our results indicate that hnRNP L regulates T cell differentiation and migration by regulating pre-TCR and chemokine receptor signaling.