Miracle-dz/UniFAR-FTUs huggingface dataset:
beta-bcc and amorphous Ti-based biocompatible alloys for human body implants

The Ti-based biocompatible human body implants of low Young's modulus and without toxic elements are developed in two regime of materials, crystalline Ti-Nb(-Sn) based alloys and amorphous Ti-Fe-Si based alloys. A series of Ti-Nb(-Sn) alloys were synthesized by copper mould suction casting and subjected to different heat treatments (furnace cooling or water quenching). The microstructure, thermal and mechanical properties of the as-cast and heat treated samples were investigated. It is shown that the addition of Sn increases the stability of the β phase. The Young's moduli of these alloys were also measured by ultrasonic measurements. Water-quenched Ti74Nb26 alloy was found to exhibits the lowest Young's modulus. Sn addition has little impact on the Young's moduli of the TiNb alloys. The Ti-Fe-Si based amorphous alloys were synthesized by melt spinning. The glass forming ability, thermal properties and corrosion properties of Ti-Fe-Si based alloys were investigated. The glassy compositions were designed according to the deep eutectic rule. It was found that the region near ternary eutectic point (Ti65Fe30Si5) is an icosahedral quasicrystal forming region, whereas the steeper side (Si rich side) of this ternary eutectic point is the glass forming region. Effect of minor elemental addition (Ge, Pd, Zr) on glass forming ability of the Ti-Fe-Si based alloys was also studied. The in situ observation of amorphization of Ti40Zr10Cu34Pd14Sn2 glassy alloy in synchrotron beam was conducted. The alloy was successfully vitrified in an aerodynamic levitation apparatus.
Functional single nucleotide polymorphisms within the cyclin-dependent kinase inhibitor 2A/2B region affect pancreatic cancer risk

The CDKN2A (p16) gene plays a key role in pancreatic cancer etiology. It is one of the most commonly somatically mutated genes in pancreatic cancer, rare germline mutations have been found to be associated with increased risk of developing familiar pancreatic cancer and CDKN2A promoter hyper-methylation has been suggested to play a critical role both in pancreatic cancer onset and prognosis. In addition several unrelated SNPs in the 9p21.3 region, that includes the CDNK2A, CDNK2B and the CDNK2B-AS1 genes, are associated with the development of cancer in various organs. However, association between the common genetic variability in this region and pancreatic cancer risk is not clearly understood. We sought to fill this gap in a case-control study genotyping 13 single nucleotide polymorphisms (SNPs) in 2,857 pancreatic ductal adenocarcinoma (PDAC) patients and 6,111 controls in the context of the Pancreatic Disease Research (PANDoRA) consortium. We found that the A allele of the rs3217992 SNP was associated with an increased pancreatic cancer risk (ORhet=1.14, 95% CI 1.01-1.27, p=0.026, ORhom=1.30, 95% CI 1.12-1.51, p=0.00049). This pleiotropic variant is reported to be a mir-SNP that, by changing the binding site of one or more miRNAs, could influence the normal cell cycle progression and in turn increase PDAC risk. In conclusion, we observed a novel association in a pleiotropic region that has been found to be of key relevance in the susceptibility to various types of cancer and diabetes suggesting that the CDKN2A/B locus could represent a genetic link between diabetes and pancreatic cancer risk.
On Effectiveness of Anomaly Detection Approaches against Unseen Presentation Attacks in Face Anti-spoofing

While face recognition systems got a significant boost in terms of recognition performance in recent years, they are known to be vulnerable to presentation attacks. Up to date, most of the research in the field of face anti-spoofing or presentation attack detection was considered as a two-class classification task: features of bona-fide samples versus features coming from spoofing attempts. The main focus has been on boosting the anti-spoofing performance for databases with identical types of attacks across both training and evaluation subsets. However, in realistic applications the types of attacks are likely to be unknown, potentially occupying a broad space in the feature domain. Therefore, a failure to generalize on unseen types of attacks is one of the main potential challenges in existing anti-spoofing approaches. First, to demonstrate the generalization issues of two-class anti-spoofing systems we establish new evaluation protocols for existing publicly available databases. Second, to unite the data collection efforts of various institutions we introduce a challenging Aggregated database composed of 3 publicly available datasets: Replay-Attack, Replay-Mobile and MSU MFSD, reporting the performance on it. Third, considering existing limitations we propose a number of systems approaching a task of presentation attack detection as an anomaly detection, or a one-class classification problem, using only bona-fide features in the training stage. Using less training data, hence requiring less effort in the data collection, the introduced approach demonstrates a better generalization properties against previously unseen types of attacks on the proposed Aggregated database.
The habenula: an under-recognised area of importance in frontotemporal dementia?

Behavioural variant frontotemporal dementia (bvFTD) is a neurodegenerative disorder characterised by atrophy of the frontal and temporal lobes and progressive behavioural and cognitive impairment. Some behavioural symptoms such as craving for food, alcohol or drugs, and hypersexuality are suggestive of abnormal reward processing. The reward circuit is formed by a number of different structures including the orbitofrontal cortex, ventral striatum (in particular the nucleus accumbens), ventral pallidum, anterior cingulate cortex, thalamus, hypothalamus, midbrain and habenula.1 This complex network combines information about motivation, cognitive planning and motor control to develop an appropriate goal-directed response to external environmental stimuli. Many of the brain structures belonging to the reward circuit have been found to be atrophic in bvFTD,2 supporting the theory that impairment of the reward system is an important factor in this disease. Among these structures, the habenula, found medial to the posterior thalamus, is uniquely positioned to participate in reward processing, acting as a convergence point for the limbic system and basal ganglia circuits,3 ,4 and therefore playing a pivotal role in the integration of information required to generate goal-directed behaviours. Despite this key role, it has yet to be investigated in bvFTD. The aim of this study was to investigate the volume of the habenula in a cohort of patients with bvFTD, hypothesising that it would be smaller than in healthy controls as well as an age-matched group of patients with Alzheimer’s disease (AD) who typically do not show impairment of reward behaviour. We also hypothesised that the habenula would show comparable atrophy to other key areas in the reward network in bvFTD. Fifteen participants fulfilling criteria for the diagnosis of bvFTD (including eight with a MAPT mutation and four with a pathogenic expansion in the C9orf72 gene) were recruited consecutively from a tertiary referral cognitive …
Abundant sunshine and vitamin D deficiency

In this issue of the British Journal of Nutrition, Islam et al. (1) and Woo et al. (2) present data from Bangladesh and China showing a high prevalence of poor vitamin D status in women of childbearing age combined with a concurrent elevation in plasma parathyroid hormone (PTH) concentration. These reports add to the growing evidence of a high prevalence of vitamin D insufficiency in countries with abundant sunshine(3-5). Vitamin D can be acquired by cutaneous synthesis following exposure to sunlight and from the diet(3-5). Vitamin D supply varies considerably worldwide, across population groups and between individuals, mainly because of differences in skin exposure to UVB radiation, the efficiency of cutaneous synthesis (for example, due to ageing and skin pigmentation) and in food fortification practices and supplement use(3,4). Vitamin D is an important determinant of bone health at all ages; deficiency causes rickets in children and osteomalacia in children and adults. A low vitamin D status has also been associated with increased bone loss and osteoporotic fracture risk in older people(6,7).
COMMD1 Promotes pVHL and O2-Independent Proteolysis of HIF-1α via HSP90/70

Background The Copper Metabolism MURR1 Domain containing 1 protein COMMD1 has been associated with copper homeostasis, NF-κB signaling, and sodium transport. Recently, we identified COMMD1 as a novel protein in HIF-1 signaling. Mouse embryos deficient for Commd1 have increased expression of hypoxia/HIF-regulated genes i.e. VEGF, PGK and Bnip3. Hypoxia-inducible factors (HIFs) are master regulators of oxygen homeostasis, which control angiogenesis, erythropoiesis, glycolysis and cell survival/proliferation under normal and pathologic conditions. Although HIF activity is mainly controlled by ubiquitination and protein degradation by the von Hippel Lindau (pVHL) tumor suppressor gene other mechanisms have recently been identified that regulate HIF signaling independently of pVHL. Principal Findings Here we characterized the mechanism by which COMMD1 regulates HIF-1α protein degradation. We show that COMMD1 competes with the chaperone heat shock protein HSP90β for binding to the NH2-terminal DNA-binding and heterodimerization domain of HIF-1α to regulate HIF-1α stability together with HSP70. Inhibition of HSP90 activity with 17-Allylamino-17-demethoxygeldanamycin (17-AAG) increased COMMD1-mediated HIF-1α degradation independent of ubiquitin and pVHL. Conclusion/Significance These data reveal a novel role for COMMD1 in conjunction with HSP90β/HSP70 in the ubiquitin and O2-independent regulation of HIF-1α.
Corporate social responsibility and Latin American firm performance

Purpose – The purpose of this paper is to analyse the impact of Corporate Social Responsibility (CSR) on firm performance in six Latin American economies. Firm performance comprises the following five distinct dimensions: firm turnover, labour productivity, innovativeness, product differentiation and technological transfer. The countries under scrutiny are Argentina, Bolivia, Chile, Colombia, Ecuador and Mexico. Design/methodology/approach – Propensity Score Matching techniques are employed to identify the causal effect of CSR on firm performance. To this end, the World Bank Enterprise Survey (2006 wave) is employed. This dataset collects relevant firm-level data Findings – CSR has a positive impact on the outcome variables analysed, suggesting that corporate goals are compatible with conscious business operations. The results also vary across countries. Research limitations/implications – The pattern that emerges from the analysis seems to suggest that the positive effects of CSR depend on a country’s stage of industrialisation. In particular, the less developed the economy, the wider the scope of CSR. Nonetheless, the relationship among conscious business operations, firm performance and countries’ levels of development is not directly tested in the present work. Practical implications – The main practical implication of the study is that Latin American firms should adopt CSR. This is because corporate responsible practices either improve firm performance or are not shown to have a detrimental effect. Social implications – The major policy implication is that emerging countries' governments as well as international organisations should provide meaningful incentives for CSR adoption. Originality/value – The paper makes three major original contributions. First, it furnishes new descriptive evidence on CSR practices in Latin America. Second, it employs a broader and novel definition of firm performance intended to capture business dynamics in developing countries, as well as to overcome data limitations. Finally, it reassesses and extends the empirical evidence on the impact of CSR on firm performance. Keywords - Corporate Social Responsibility, Firm Performance, Propensity Score Matching, Latin America
Long time behavior of diffusions with Markov switching

Let $Y$ be an Ornstein-Uhlenbeck diffusion governed by an ergodic finite state Markov process $X$: $dY_t=-\lambda(X_t)Y_tdt+\sigma(X_t)dB_t$, $Y_0$ given. Under ergodicity condition, we get quantitative estimates for the long time behavior of $Y$. We also establish a trichotomy for the tail of the stationary distribution of $Y$: it can be heavy (only some moments are finite), exponential-like (only some exponential moments are finite) or Gaussian-like (its Laplace transform is bounded below and above by Gaussian ones). The critical moments are characterized by the parameters of the model.
A Stretchable Pressure-Sensitive Array Based on Polymer Matrix

Herein, a flexible 6 × 6 pressure-sensitive array (based on the PDMS (Polydimethylsiloxane) porous substrate) was designed. We have developed a facile method to fabricate the porous substrate, by a single-step operation using the sugar-template method. This strategy effectively diminishes the complexity of the preparation process, as well as the device structure. The electrical resistivity of the stretchable array demonstrates the negative piezo resistive coefficient (NPRC) under 0–100 kpa. Moreover, the pressure-sensitive array reveals a high sensitivity and low delay time (<0.5 s) to the applied forces. Therefore, the pressure distribution could be easily recognized by testing its conductivity changes. Besides, these signal data can be collected into the upper computer, with the purpose of tracking and analyzing the azimuth of the applied loading. This cost-effective micro array has a broad application prospect for fabricating the tactile sensor, artificial skin, and human-computer interfaces.
Autonomic Responses to Ultrasound-Guided Percutaneous Needle Electrolysis: Effect of Needle Puncture or Electrical Current?

Abstract Objective: The aim of this study was to establish if the changes in sympathetic and parasympathetic activity (analyzed through heart-rate variability [HRV]) during ultrasound (US)-guided percutaneous needle electrolysis (PNE) is due to the effect of needle puncture only or of the PNE technique per se where the puncture and galvanic current are combined. Methods: This was an experimental, case-control study that took place at the University of Seville. Subjects were 36 male footballers who were randomly allocated to three groups: a control group (CG; 12 players), for whom HRV was recorded for 10 min, both at rest and during an exhaustive US examination of the patellar tendon and adjacent structures; a first experimental group (PNE group; 12 players), for whom HRV was recorded for 10 min, both at rest and during application of US-guided PNE in the patellar tendon; and a second experimental group (needle group; 12 players), for whom HRV was recorded for 10 min, both at rest and during application of.
CDK-dependent phosphorylation of PHD1 on serine 130 alters its substrate preference in cells

ABSTRACT PHD1 (also known as EGLN2) belongs to a family of prolyl hydroxylases (PHDs) that are involved in the control of the cellular response to hypoxia. PHD1 is also able to regulate mitotic progression through the regulation of the crucial centrosomal protein Cep192, establishing a link between the oxygen-sensing and the cell cycle machinery. Here, we demonstrate that PHD1 is phosphorylated by CDK2, CDK4 and CDK6 at S130. This phosphorylation fluctuates with the cell cycle and can be induced through oncogenic activation. Functionally, PHD1 phosphorylation leads to increased induction of hypoxia-inducible factor (HIF) protein levels and activity during hypoxia. PHD1 phosphorylation does not alter its intrinsic enzymatic activity, but instead decreases the interaction between PHD1 and HIF1α. Interestingly, although phosphorylation of PHD1 at S130 lowers its activity towards HIF1α, this modification increases the activity of PHD1 towards Cep192. These results establish a mechanism by which cell cycle mediators, such as CDKs, temporally control the activity of PHD1, directly altering the regulation of HIF1α and Cep192. Summary: CDK-mediated phosphorylation of PHD1 at serine 130 controls target specificity and confers cell cycle regulation of PHD1.
New developments in optical coherence tomography imaging for glaucoma

Purpose of review Since its introduction in ophthalmology, optical coherence tomography (OCT) has undergone significant advances in imaging protocols, algorithms, and addition of new parameters which have maximized its potential for diagnosing, evaluating the response to treatment, and assessing the progression of various ocular diseases, including glaucoma. This review provides an update on recent developments in OCT with respect to the management of glaucoma. Recent findings Most recent notable developments include the introduction of the minimum distance band, which is a three-dimensional optic nerve head parameter, and Swept-Source OCT with its single wide-field scanning capability. The introduction of OCT angiography provides additional structural and functional measures for glaucoma management. Adaptive optics helps visualize individual RNFL bundles and measure their widths. Summary Continued improvements in OCT technology is both enhancing our understanding of glaucoma and improving our ability to manage the disease.
Observation-based expectation generation and response for believable reactive agents

In this paper we describe how to improve the believability and robustness of reactive agents by enabling them generate short-term, observation-based expectations about the world and react appropriately to violations of those expectations. We motivate our work by discussing how expectations are essential for building agents with robust and believable behavior, and then propose a model for generating expectations and responding to their violation. Finally, we outline our results from incorporating such a model into our behavior architecture. Areas: lifelike characters, common-sense reasoning, belief revision, software agents
Physiological mechanisms constraining ectotherm fright-dive performance at elevated temperatures

ABSTRACT Survival of air-breathing, diving ectotherms is dependent on their capacity to optimise the time available for obligate underwater activities, such as predator avoidance. Submergence times are thermally sensitive, with dive durations significantly reduced by increases in water temperature, deeming these animals particularly vulnerable to the effects of climate change. The physiological mechanisms underlying this compromised performance are unclear but are hypothesised to be linked to increased oxygen demand and a reduced capacity for metabolic depression at elevated temperatures. Here, we investigated how water temperature (both acute and chronic exposures) affected the physiology of juvenile estuarine crocodiles (Crocodylus porosus) performing predator avoidance dives (i.e. fright-dives). Diving oxygen consumption, ‘fright’ bradycardia, haematocrit and haemoglobin (indicators of blood oxygen carrying capacity) were assessed at two test temperatures, reflective of different climate change scenarios (i.e. current summer water temperatures, 28°C, and ‘high’ climate warming, 34°C). Diving oxygen consumption rate increased threefold between 28 and 34°C (Q10=7.4). The capacity to depress oxygen demand was reduced at elevated temperatures, with animals lowering oxygen demand from surface levels by 52.9±27.8% and 27.8±16.5% (means±s.e.m.) at 28°C and 34°C, respectively. Resting and post-fright-dive haematocrit and haemoglobin were thermally insensitive. Together these findings suggest decrements in fright-dive performance at elevated temperatures stem from increased oxygen demand coupled with a reduced capacity for metabolic depression. Highlighted Article: Investigation of the physiological mechanisms underlying compromised fright-dive capacity at elevated temperatures in juvenile estuarine crocodiles indicates that reduced capacity for metabolic depression and increased metabolic demands underlie shortened dive durations.
Twin Networks: Matching the Future for Sequence Generation

We propose a simple technique for encouraging generative RNNs to plan ahead. We train a "backward" recurrent network to generate a given sequence in reverse order, and we encourage states of the forward model to predict cotemporal states of the backward model. The backward network is used only during training, and plays no role during sampling or inference. We hypothesize that our approach eases modeling of long-term dependencies by implicitly forcing the forward states to hold information about the longer-term future (as contained in the backward states). We show empirically that our approach achieves 9% relative improvement for a speech recognition task, and achieves significant improvement on a COCO caption generation task.
Paradoxical Impact of Two Folate Receptors, FRα and RFC, in Ovarian Cancer: Effect on Cell Proliferation, Invasion and Clinical Outcome

Despite being an essential vitamin, folate has been implicated to enhance tumor growth, as evidenced by reports on overexpression of folate receptor alpha (FRα) in carcinomas. The role of another folate transporter, reduced folate carrier (RFC), is largely unknown. This study investigated the roles of folate, FRα and RFC in ovarian cancers. We demonstrated FRα mRNA and protein overexpression and reduced RFC expression in association with FRα gene amplification and RFC promoter hypermethylation, respectively. FRα overexpression was associated with tumor progression while RFC expression incurred a favorable clinical outcome. Such reciprocal expression pattern was also observed in ovarian cancer cell lines. Folate was shown to promote cancer cell proliferation, migration and invasion in vitro, and down-regulate E-cadherin expression. This effect was blocked after either stable knockdown of FRα or ectopic overexpression of RFC. This hitherto unreported phenomenon suggests that, RFC can serve as a balancing partner of FRα and confer a protective effect in patients with high FRα-expressing ovarian carcinomas, as evidenced by their prolonged overall and disease-free survivals. In conclusion, we report on the paradoxical impact of FRα (putative oncogenic) and RFC (putative tumor suppressive) in human malignancies. FRα and RFC may potentially be explored as therapeutic target or prognostic marker respectively. We recommend caution and additional research on folate supplements in cancer patients.