Miracle-dz/UniFAR-FTUs huggingface dataset:
High Degree of Variability in Reporting of Clinical and Patient-Reported Outcomes After Hip Arthroscopy

Background: Hip arthroscopy for the treatment of intra-articular pathology is a rapidly expanding field. Outcome measures should be reported to document the efficacy of arthroscopic procedures; however, the most effective outcome measures are not established. Purpose: To evaluate the variability in outcomes reported after hip arthroscopy and to compare the responsiveness of patient-reported outcome (PRO) instruments. Study Design: Systematic review. Methods: We reviewed primary hip arthroscopy literature between January 2011 and September 2016 using the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Patient and study characteristics were recorded. Pre- and postoperative means and SDs of PROs were recorded from articles that used 2 or more PROs with a 1-year minimum follow-up. From this subset of articles, we compared the responsiveness between PRO instruments using the effect size, standard response mean, and relative efficiency. Results: We identified 130 studies that met our inclusion/exclusion criteria, which totaled 16,970 patients (17,511 hips, mean age = 37.0 years, mean body mass index = 25.9 kg/m2). Radiographic measures were reported in 100 studies. The alpha angle and center-edge angle were the most common measures. Range of motion was reported in 81 of 130 articles. PROs were reported in 129 of 130 articles, and 21 different PRO instruments were identified. The mean number of PROs per article was 3.2, and 78% used 2 or more PROs. The most commonly used PRO was the modified Harris Hip Score, followed by the Hip Outcome Score (HOS)–Activities of Daily Living, HOS-Sport, visual analog scale, and Nonarthritic Hip Score (NAHS). The 2 most responsive PRO tools were the International Hip Outcome Tool (iHOT)–12 and the NAHS. Conclusion: Outcomes reporting is highly variable in the hip arthroscopy literature. More than 20 different PRO instruments have been used, which makes comparison across studies difficult. A uniform set of outcome measures would allow for clearer interpretation of the hip arthroscopy literature and offer potential conclusions from pooled data. On the basis of our comparative responsiveness results and previously reported psychometric properties of the different PRO instruments, we recommend more widespread adoption of the iHOT PROs instruments to assess hip arthroscopy outcomes.
Women in ICT: Barriers to career advancement and strategies for improvement

Women are generally under-represented in the technology, or ICT, industry. Their numbers dwindle as they advance to senior management, with only 19% of senior posts assumed by women [1]. This paper looked at barriers to career advancement of women in ICT, strategies to bridge them and the strategies seen as the most effective by study participants. Data was collected through online questionnaire from 50 women occupying ICT posts in Gauteng Province, South Africa. We analysed the data using a combination of descriptive statistics and coding. The most prevalent career advancement barriers identified were the male-dominated nature of the sector, lack of empowerment and work-life imbalance. Participants believe that the use of quota systems for gender diversity, transparent performance reviews and opportunities for women, will be effective to bridge these barriers. Our findings mirror typical trends in the male-dominated ICT industries across the globe.
Telomerase Reverse Transcriptase Gene from Greasyback Shrimp Metapenaeus ensis: Isolation, Genomic Organization and Expression Pattern Analysis

Telomerase reverse transcriptase (TERT), a catalytic subunit of telomerase, plays a key role in the activity and biological functions of telomerase. In the present study we isolated and characterized the full-length cDNA and DNA sequences of the TERT gene (MeTERT) from Metapenaeus ensis. MeTERT cDNA was 4239 bp in length, which consisted of a 369 bp 5′UTR, a 3231 bp open reading frame encoding 1076 amino acids, and a 639 bp 3′UTR. The genomic DNA of MeTERT had only two introns, similar to beetle (two introns) and silkworm (intronless). The MeTERT protein showed only 5.2–7.9% identity with other known TERTs but contained all the four primary TERT domains of the N-terminal TEN, RNA binding domain (TRBD), reverse transcriptase (RT) and C-terminus CTE. Expression pattern analysis by RT-qPCR showed that, the MeTERT mRNA transcripts could be detected in all the tested samples, with relatively higher expression level in the gill, mysis, Oka organ and egg, but lower level in muscle, ovary, in vitro cultured 3-d Oka organ cells and heart. The significant decrease of MeTERT expression in the in vitro cultured 3-d Oka organ primary cells compared with their source tissue of Oka organ may have contributed to the cellular mitosisarrest. Thus trans-activation of TERT gene may be a candidate in attempts to immortalize in vitro cultured shrimp cells. This work will lay a solid foundation for future studies of the biological functions of telomerase in crustaceans.
The ICS-FORTH SWIM: A Powerful Semantic Web Integration Middleware

Semantic Web (SW) technology aims to facilitate the integration of legacy data sources spread worldwide. Despite the plethora of SW languages (e.g., RDF/S, DAML+OIL, OWL) recently proposed for supporting large scale information interoperation, the vast majority of legacy sources still rely on relational databases (RDB) published on the Web or corporate intranets as virtual XML. In this paper, we advocate a Datalog framework for mediating high-level queries to relational and/or XML sources using community ontologies expressed in a SW language such as RDF/S. We describe the architecture and the reasoning services of our SW integration middleware, called SWIM, and we present the main design choices and techniques for supporting powerful mappings between different data models, as well as, reformulation and optimization of queries expressed against mediation schemas and views.
Neuroplasticidad: aspectos bioquímicos y neurofisiológicos

Neuroplasticity is the potentiality of the nervous system to change itself and to form neural connections in response to a new information, sensorial stimulation, development, dysfunction or damage. In general, neuroplasticity is often associated with learning during the childhood, but their definitions its going further, and it has an historical follow-up. There are many biochemical and physiological components behind neuroplasticity process, and this leads to biomolecular, chemical, genomics and proteomics processes, that requiring intra and extra-neuronal actions to generate a neural response
Clinical and Immunologic Features of an Atypical Intracranial Mycobacterium avium Complex (MAC) Infection Compared with Those of Pulmonary MAC Infections

ABSTRACT Members of the Mycobacterium avium complex (MAC) may cause chronic pulmonary infections in otherwise healthy elderly persons but rarely invade parts of the body outside of the lungs in immunocompetent hosts. We present a case of an isolated intracranial MAC infection in an apparently immunocompetent individual and review previous reports. We studied the T-cell and monocyte responses in healthy volunteers, individuals with a pulmonary MAC infection, and one individual with an isolated intracranial MAC infection. Genomic DNA from the individual with the brain MAC infection was studied for gamma interferon (IFN-γ) receptor mutations. Individuals with localized pulmonary MAC infections showed increased activation of monocytes and enhanced monocyte and T-cell tumor necrosis factor alpha (TNF-α) production in response to lipopolysaccharide and MAC antigens but defects in T-cell IFN-γ secretion. The individual with an intracranial MAC infection showed a lack of monocyte activation and deficiencies in both monocyte and T-cell TNF-α production and monocyte interleukin-12 (IL-12) production but had preserved T-cell IFN-γ production. Mutations or deletions in the IFN-γ receptor were not detected in the individual with the intracranial MAC infection. Our data suggest that distinct immune defects characterize two different manifestations of MAC infection. A relative defect in IFN-γ production in response to MAC may predispose an individual to localized but partially controlled lung disease, whereas defects leading to reduced IL-12 and TNF-α production may allow the dissemination of MAC. Further studies delineating the potential role of TNF-α in limiting the spread of MAC outside the lung are warranted.
Learning in Real-Time Strategy Games

One of the main drawbacks in Real-time strategy (RTS) games is that the built-in artificial intelligence (or gamebots) tend to lag behind human players. To make gamebots perform like human players, gamebots should try to find best action from the Knowledge (training data) for each time-stamp and should be able to play game against every opponent. To achieve this end in this paper we propose a learning approach called Individual Action Plan Learning where each plan has exactly just one action during training. While executing, i.e., playing, we make use of the sensor information from the current game-state (map) to select the best action. There are two main advantages of having such an approach as compared to other works in RTS: (1) we can do away with the concept of a simulator which are often game specific and is usually hard coded in any type of RTS games (2) our system can learn from merely observing humans playing games and do not need any authoring effort. Usually RTS requires demonstrations to be annotated. Two AI games called Battle City and S3 were used to evaluate our approach.
Open Source In-Memory Data Grid Systems: Benchmarking Hazelcast and Infinispan

Distributed cache systems are used to store and retrieve frequently used data for faster access by exploiting the memory of more than one machine, but they appear as one logical big cache. In this paper, we studied the performance of two popular open source distributed cache systems (Hazelcast and Infinispan) indifferently. The conducted performance analysis shows that Infinispan outperforms Hazelcast in the simple data retrieval scenarios as well as most of SQL-like queries scenarios, whereas Hazelcast outperforms Infinispan in SQL-like queries for small data sizes.
Kidney function in early diabetes: the tubular hypothesis of glomerular filtration.

At the onset of diabetes mellitus, the glomerular filtration rate becomes supranormal. Discovery science has identified many abnormalities in the early diabetic kidney that apparently contribute to this phenotype. A serviceable understanding of the early diabetic kidney requires this information to fit together. It is the purpose of this article to present an archetype that explains multiple nuances of kidney function in early diabetes. We refer to this archetype as the "tubular hypothesis of glomerular filtration. " Its basic tenet is that strange effects of diabetes on glomerular filtration stem from primary effects on the proximal tubule or loop of Henle that impact glomerular filtration by feedback through the macula densa. This theory can explain diabetic hyperfiltration, a paradoxical effect of dietary salt on glomerular filtration rate in diabetes, and the renal response to dietary protein and amino acid infusion in diabetes. The discussion centers on the kidney as an integrated system of parts rather than on the specific cellular mechanisms that comprise those parts.
Multi-channel collaborative spectrum sensing in cognitive radio networks

Collaborative spectrum sensing (CSS) consumes a significant amount of energy during sensing and reporting the sensing results. Such an issue becomes a challenge in the multi-channel systems. In this paper we propose two different energy-efficient CSS schemes, namely, Reduced-Energy Sensing Scheme (RESS) and Reduced-Energy Reporting Scheme (RERS). In RESS, the channels that have been identified as occupied will not be sensed for a number of next sensing rounds, while in RERS, only the sensing results of a subset of the sensed channels will be reported channels. In both schemes, the energy and time resources expended in CSS will be saved. Moreover, the saved time will be exploited in data transmission, improving the throughput. Simulation results show a significant improvement in the energy efficiency of multi-channel CSS.
Campbell's Psychiatric Dictionary

The eighth edition of this authoritative and highly acclaimed dictionary continues to pursue its goal of keeping readers abreast of new developments in psychiatry. Technological advances have enabled researchers to trace neurotransmission, to uncover the mechanisms of drug action, and to monitor brain activity in real time. Psychiatry has increasingly embraced the neurosciences in studies of learning and memory, sleep and dreaming, and behavioural genetics. There has been cross-fertilization with different fields - among them pharmacology, physiology, biochemistry, and experimental and developmental psychology - and many terms from those disciplines have been incorporated into the Dictionary. This thoroughly revised edition reflects achievements not only in the basic sciences but also in their practical application, as well as changes in the organization and delivery of health care. It covers the full range of treatments for mental illness including psychopharmacologic agents, psychoanalysis, behaviour therapy, cognitive therapy, interpersonal therapy, and other brief therapies. Studies of different forms and combinations of treatments continue to refine and individualize approaches to the particular patient. To make all of this meaningful to mental health professionals and to those outside that field who are interested in what psychiatry is doing to meet the needs of patients, the editor has retained the encyclopaedic approach to the definition of important terms. The eighth edition will be invaluable to psychiatrists and neurologists (and their students and trainees), to psychologists, nurses, social workers, counsellors, lawyers, claims reviewers, and to the lay reader.
Contribution à la sécurité des communications des réseaux de capteurs sans fil

Les reseaux de capteurs sans fil (RCSF) sont devenus un theme porteur aussi bien pour la recherche academique que pour les activites des services de R&D en raison de leur simplicite de deploiement et de leur potentiel applicatif dans des domaines tres varies (militaire, environnemental, industriel). Un RCSF est compose d'un ensemble de noeuds devant etre operationnels et autonomes energetiquement pour de longues periodes. De ce fait ils sont limites en capacite memoire et de calcul, et contraint a exploiter une faible puissance de transmission, ce qui en limite leur portee et rend leur debit modeste. Le besoin de securiser les communications dans un RCSF depend de la criticite des donnees echangees pour l'application supportee. La solution doit reposer sur des echanges surs, confidentiels et fiables. Pour assurer la securisation des echanges, des techniques de cryptographie existent dans la litterature. Concues a l'origine pour des reseaux informatiques majoritairement câbles, elles se basent generalement sur des algorithmes complexes et gourmands en ressource. Dans le cadre de cette these, nous avons propose, implemente et evalue une architecture securisee et dynamique adaptee aux communications des RCSF. Elle permet de garantir et de maintenir la securite des communications durant toute la duree de vie d'un reseau multi-saut. Nous avons utilise et adapte des algorithmes standards de cryptographie, tels que AES-CTR et la suite d'algorithmes basee sur ECC, qui permettent a notre architecture de resister a la majorite d'attaques. Nous avons quantifie le surcout en temps de calcul et en occupation memoire de notre solution. Les resultats d’implementation de notre proposition sont issus de mesures reelles faites sur une maquette realisee a partir de cartes TelosB.
Effects of Plasma Glucose Concentration on Glucose Utilization and Glucose Clearance in Normal Man

Glucose clearance (glucose utilization ÷ plasma glucose) is commonly used to assess glucose utilization under conditions in which plasma glucose concentrations vary. The validity of this practice requires that glucose clearance itself be independent of plasma glucose concentration. The present studies were, therefore, undertaken to determine the relationship between glucose clearance and plasma glucose concentration in man. Using the glucose clamp technique, rates of glucose utilization (measured isotopically with 3-3H-glucose) and glucose clearance were determined in 5 normal volunteers at steady-state plasma glucose concentrations of approximately 60, 95,130, and 165 mg/dl, while plasma insulin concentrations were maintained constant (∼18 μU/ml) by infusion of insulin and somatostatin. Despite virtually identical 0.4 mg · kg−1 · min−1 increments in glucose utilization for each 35-mg/dl increment in plasma glucose, glucose clearance decreased as a function of plasma glucose concentration (r = − 0.85, P < 0.001). These results indicate that glucose clearance is not independent of changes in plasma glucose concentration and, thus, use of glucose clearance to evaluate glucose utilization at differing plasma glucose concentration is not valid. Whether this conclusion also applies to similar use of clearance for other substrates remains to be determined.
Elucidating determinants of the plateau in oxygen consumption at o2max

Background: A plateau in oxygen consumption (o2) is the primary means of confirming that maximal oxygen uptake (o2max) is attained during incremental exercise to fatigue. However, it is still unresolved what causes expression of a plateau in o2 at the end of incremental exercise. Objectives: To elucidate incidence and identify determinants of the o2 plateau in subjects of varying fitness. Methods: Thirty subjects (mean (SD) age and o2max 26.9 (9.8) years and 3.4 (0.8) litre/min respectively) were separated into three groups: endurance trained (ET; n = 9), recreationally active (Rec; n = 11), and strength/sprint trained (STR; n = 10). During three separate visits, subjects completed incremental treadmill exercise during which breath by breath gas exchange data were obtained. Body composition was measured using a three site skinfolds model. Force production of the knee extensors and flexors was assessed using isokinetic dynamometry. Results:o2max was significantly higher (p<0.05) in the ET group vs STR and Rec. The change in o2 (Δo2) at o2max was not different (p>0.05) in the ET group (33.0 (27.3) ml/min) compared with the Rec group (30.3 (24.1) ml/min) and the STR group (44.4 (23.8) ml/min). No correlations (p>0.05) were evident between Δo2 at o2max and o2max (r = 0.05), fat-free mass (r = 0.12), and muscular strength (r = −0.12). Conclusions: The incidence of a plateau in o2 at o2max (from correlation data) is not due to factors related to training status or physical fitness of subjects, but is altered by analysis and interpretation of gas exchange data.
Mental and Spiritual Relaxation by Recitation of the Holy Quran

Nowadays, Tension or Stress is a common and serious problem in our Global Village. Stress and stress related factors contribute to tension and reduced ability to handle life's everyday challenges. This paper proposes a new method to reduce the stress and tension of our life and also proves that mentally, spiritually and physically relaxation can be achieved by the recitation of the holy Quran. In this technique of listening, reading and watching the text of the Holy Quran subject (User) can involve the whole body. The entire process will be controlled by brain, as a result during this practice the whole body will receive relaxation/refreshment, and the exhaustion, boring and tiredness will be finished. This physiological biofeedback manner provides groceries for spirit. Hence this means can be used in hospitals for mentally disturb and depression effected patients, for relaxation of the soldiers, for refreshing the students, to cool down workers in industries and for the entertainment of passengers in buses and airplanes. This approach replaces negative thoughts with positive and truthful thoughts.
Analysis of the Surgical Outcome and Prognostic Factors for Hilar Cholangiocarcinoma: A Chinese Experience

Purposes: Hilar cholangiocarcinoma (HC) is the most common location for bile duct cancer. It represents a significant technical challenge for surgical operation due to the close proximity to major vascular structures and to the liver and arborization of the right and left biliary tree. The objective of this study was to assess the therapeutic strategies and prognostic factors that could influence the clinical outcome of HC. Methods: From January 1990 to December 2009, a total of 215 HC patients undergoing resection were included in this study. Survival and follow-up were calculated from the date of initial histologic diagnosis to the dates of first recurrence or death and last contact, respectively. Uni- and multivariate analyses were performed to examine factors affecting clinical outcome and recurrence. Results: 215 patients underwent resection: 141 (65.6%) had an R0 resection (negative histologic margins), 46 (21.4%) had an R1 resection (positive histologic margins), 28 (13.0%) had an R2 resection. The 1-, 3- and 5-year cumulative survival rates (%) of the patients were 60.3, 37.2 and 29.7%. The median survival time after R0 resection was 47.1 months, 17.2 months after R1 resection, and 12.1 months after R2 resection. The results from univariate analyses suggest that poor histopathological grade (p = 0.004), lymph node metastasis (p = 0.000), vascular invasion (p = 0.005), neuroinvasion (p = 0.044), R1 resection (p = 0.000) and T2 or T3 stage (p = 0.009) were significant predictors for poor survival rates. By multivariate analysis, only the lymph node metastasis (RR = 2.450, 95% CI 1.677–3.579) and R1 resection (RR = 0.283, 95% CI 0.183–0.437) were significantly associated with poor survival rates. Conclusions: Negative histologic margins were associated with improved outcome after all HC resections. Complete resection remains the only therapy that offers the possibility of long-term survival, and hepatic resection is a critical component of the surgical approach.
Evaluation of Knowledge and Attitude of Parents of Attention Deficit/Hyperactivity Disorder Children towards Attention Deficit/Hyperactivity Disorder in Clinical Samples

Objective: Knowledge and attitude of parents about attention deficit/hyperactivity disorder (ADHD) is an important factor in management of the disorder in children. This study investigates the parents’ knowledge and attitude towards ADHD, its symptoms, diagnosis, treatment and prognosis. Method: In this cross-sectional descriptive study, the subjects were 150 parents (120 mother and 30 father) of ADHD children who were referred to a child psychiatry clinic affiliated in university of social welfare and rehabilitation sciences in Tehran. The diagnosis was made by a child psychiatrist according to DSM-IV TR criteria. The parents completed a 40 items questionnaire that was prepared by the authors and assessed their knowledge and attitude towards ADHD and source of their information. Results: The most common source of parent’s information about ADHD was TV. The parent’s knowledge about the symptoms of the disorder was relatively good. But in regard to diagnosis, treatment and prognosis of the disorder, they have very low knowledge and even incorrect beliefs. The parent’s knowledge significantly correlated with their educational level (p=0.01). Conclusion: In general, knowledge of the parents was low and it can lead to misdiagnosis or mismanagement of this common and important disorder and need to further consideration in terms of educating parents about the disorder in media specially TV.