Miracle-dz/UniFAR-FTUs huggingface dataset:
Accelerometer derived load according to playing position in competitive youth soccer

The integration of accelerometers and Global Positioning Systems (GPS) provides the opportunity to objectively measure a players work output Although these systems have been widely adopted at the elite level, a positional profile of the external demands of soccer is currently missing from the literature. This study aimed to investigate the acceleration, deceleration and triaxial player load during competitive youth football. Eight 11v11 games were monitored during the competitive phase of the 2012-2013 season, using Catapult Minimax 5Hz GPS and 100Hz accelerometers. Analysis showed that wide midfielders completed significantly more maximal acceleration and deceleration actions. There were no reductions between playing halves in maximal acceleration or deceleration actions, across all playing positions. Central midfielders had a significantly higher total load, and a higher Y axis load compared to central defenders.
Modelling of Conflict Controlled Networks

Abstract : Game theoretical techniques have recently become prevalent in many engineering applications, notably in communications. While developing an information network management system often encountered a situation where one should deal with malicious intrusion attempts aimed at obstructing the routing policy work. In this case, methods of networks management based on fluid models and a discrete controlled random walk model requires certain changes. In this work we propose an approach based on conflict control point of view that could be useful for modeling of attacking actions and response behaviour of the system.
Extended MPEG Video Format for Efficient Dynamic Voltage Scaling

We present an extended MPEG video format for efficient Dynamic Voltage Scaling (DVS). DVS technique has been widely researched, but the execution time variation of a periodic task (i.e. MPEG decoding) is still a challenge to be tackled. Unlike previous works, we focus on the data (video stream) rather than the execution code to overcome such limitation. The proposed video format provides the decoding costs of frames to help the precise prediction of their execution times at client machines. The experimental results show that the extended format only increases the data size less than 1% by adding about 10 bits representing the decoding cost of each frame. Also, a DVS technique adjusted for the proposed format achieves 90% of efficiency compared to the oracle case, while keeping the run time overhead of the technique negligible.
Fault tolerant control on robotic manipulator using sliding mode observers

Fault tolerance is increasingly important in industrial robots. The ability to detect and tolerate failures allows robots to effectively cope with internal failures and continue performing designated tasks without the need for immediate human intervention. This paper presents new fault detection algorithms which detect failures in robot components using sliding-mode observers. An intelligent fault tolerance framework is proposed in which the detection algorithms work to detect and tolerate sensor or motor failures in a robot system. The nonlinear observer is designed to provide the estimation of unmeasurable state and modelling uncertainty, which are used to construct fault estimation algorithm. The effectiveness of the control and the fault tolerance strategy is analyzed in simulation.
Analyzing the impact of data vectorization on distance relations

Some popular algorithms used in Music Information Retrieval (MIR) such as Self-Organizing Maps (SOMs) require the objects they process to be represented as vectors, i.e. elements of a vector space. This is a rather severe restriction and if the data does not adhere to it, some means of vectorization is required. As a common practice, the full distance matrix is computed and each row of the matrix interpreted as an artificial feature vector. This paper empirically investigates the impact of this transformation. Further, an alternative approach for vectorization based on Multidimensional Scaling is proposed that is able to better preserve the actual distance relations of the objects which is essential for obtaining a good retrieval performance.
Using Differencing to Increase Distinctiveness for Phishing Website Clustering

Phishing webpages present a previously underused resource for information on determining provenance of phishing attacks.Phishing webpages aim to impersonate a legitimate website in order to trick their potential victims into revealing their confidential data, such as usernames and passwords.However different phishing webpages often contain small differences and these differences can provide a great deal of evidence on the provenance of phishing attacks.When impersonating a webpage, there is often a large amount of `redundant' information, as much of the original, impersonated website is found in phishing websites, making phishing websites across different attacks very similar.In order to attempt to overcome this issue, a diff can be used which takes the phishing and original websites as input and returns the differences between the two.These differences present a new view on the data that is previously unused and presents a novel way to increase the ability of clustering algorithms to find good, distinct and separated clusters within the data.The research presented here outlines this diff process and shows that for the data used, comparable results were obtained while the dimensionality of the dataset was reduced.This reduction in size allows for clustering algorithms to complete faster, due to the reduced dimensionality of the dataset.
SharkDB: An In-Memory Column-Oriented Trajectory Storage

The last decade has witnessed the prevalence of sensor and GPS technologies that produce a high volume of trajectory data representing the motion history of moving objects. However some characteristics of trajectories such as variable lengths and asynchronous sampling rates make it difficult to fit into traditional database systems that are disk-based and tuple-oriented. Motivated by the success of column store and recent development of in-memory databases, we try to explore the potential opportunities of boosting the performance of trajectory data processing by designing a novel trajectory storage within main memory. In contrast to most existing trajectory indexing methods that keep consecutive samples of the same trajectory in the same disk page, we partition the database into frames in which the positions of all moving objects at the same time instant are stored together and aligned in main memory. We found this column-wise storage to be surprisingly well suited for in-memory computing since most frames can be stored in highly compressed form, which is pivotal for increasing the memory throughput and reducing CPU-cache miss. The independence between frames also makes them natural working units when parallelizing data processing on a multi-core environment. Lastly we run a variety of common trajectory queries on both real and synthetic datasets in order to demonstrate advantages and study the limitations of our proposed storage.
On some delayed nonlinear parabolic equations modeling CO oxidation

It is known that several features of many react ion-diffusion systems can be studied through an associated Complex Ginzburg-Landau Equation (CGLE). In particular, the study of the catalytic CO oxidation leads to the Krischer-Eiswirth-Ertl model, a nonlinear parabolic system, which can be controlled by a delayed feedback term. For the control of its uniform oscillations, we had already studied the corresponding delayed CGLE, developing first a pseudolinearization principle, of a very broad applicability, which led us to a range of parameters for the stability of those oscillations. In this work we first present some simulations which confirm the mentioned range of parameters, and gives other ranges for different behavior. Out of the setting of the CGLE, the dynamics is richer, so we present another method for the study of the existence, (monotonicity methods) and stability (with the pseudolinearization principle), directly for the mentioned parabolic system.
Self-regulatory processes in early personality development: A multilevel approach to the study of childhood social withdrawal and aggression

Self-regulatory processes are believed to be critical to early personality and behavioral adjustment. Such processes can be observed on multiple levels, including the physiological, attentional, emotional, cognitive, and interpersonal domains of functioning. Data from several longitudinal studies suggest links between early temperamental tendencies such as behavioral inhibition and frustration tolerance, and regulatory developments at the levels of physiological, attentional, and emotional regulation. Deficits in these particular levels of self-regulation may underlie childhood social withdrawal and aggression. Significant gaps remain in our knowledge of the pathways to disordered behavior and the role that self-regulation plays in such pathways. Suggestions are made for the ways in which future longitudinal studies might address these gaps.
Dynamic service composition for wireless Web access

Describes a Web proxy architecture called WebPADS, short for "Web Proxy for actively deployable services. " The RebPADS was developed to enhance Web applications running on a wireless network. The RebPADS provides mechanisms to automatically locate and configure a flexible and adaptive wireless Web proxy. In addition, it provides a framework that facilitates the development of add-on services, where the services can be actively deployed and migrated across Web proxies, in order to adapt to the changing wireless environment.
Evaluation of the Effect of Nebulized N-Acetylcysteine on Respiratory Secretions in Mechanically Ventilated Patients: Randomized Clinical Trial

Background The purpose of our study was to evaluate an inexpensive and available method to reduce mucous impactions in mechanically ventilated patients. Methods This randomized clinical trial was conducted on 40 mechanically ventilated patients aged 15-90 years. The patients were randomly allocated into two arms; 20 cases and 20 controls. The cases received N-acetylcysteine via their nebulizers, and the control group received normal saline three times a day for one day. We measured the density of respiratory secretion, plateau and peak airway pressures, and O2 saturation at baseline, 12 and 24 hours later. Results Although the mean secretion density was significantly lower in the NAC group (F (1, 38)=8.61, P=0.006), but a repeated measures ANOVA with a Greenhouse-Geisser correction determined that the effect of NAC on mean secretion density did not differ significantly between time points (F (1, 38)=3.08, P=0.087). NAC increased O2 saturation significantly between time points (F (1.92, 73.1)=4.6, P=0.014). The plateau airway pressures were relatively stable throughout the study in the normal saline and NAC groups (F (1.95, 37.1)=0.67, P=0.513). The peak airway pressure did not change significantly during the study in the normal saline and NAC groups (F (1.52, 56.4)=0.91, P=0.384). Conclusion Considering the limitations of the study, nebulized NAC in mechanically ventilated patients was not effective more than normal saline nebulization in reducing the density of mucous plugs. The peak and plateau airway pressures were relatively stable throughout the study in both groups. Trial Registration Number: IRCT201104276312N1.
Facial Expression Recognition Takes Longer in the Posterior Superior Temporal Sulcus than in the Occipital Face Area

Neuroimaging studies have identified a face-selective region in the right posterior superior temporal sulcus (rpSTS) that responds more strongly during facial expression recognition tasks than during facial identity recognition tasks, but precisely when the rpSTS begins to causally contribute to expression recognition is unclear. The present study addressed this issue using transcranial magnetic stimulation (TMS). In Experiment 1, repetitive TMS delivered over the rpSTS of human participants, at a frequency of 10 Hz for 500 ms, selectively impaired a facial expression task but had no effect on a matched facial identity task. In Experiment 2, participants performed the expression task only while double-pulse TMS (dTMS) was delivered over the rpSTS or over the right occipital face area (rOFA), a face-selective region in lateral occipital cortex, at different latencies up to 210 ms after stimulus onset. Task performance was selectively impaired when dTMS was delivered over the rpSTS at 60–100 ms and 100–140 ms. dTMS delivered over the rOFA impaired task performance at 60–100 ms only. These results demonstrate that the rpSTS causally contributes to expression recognition and that it does so over a longer time-scale than the rOFA. This difference in the length of the TMS induced impairment between the rpSTS and the rOFA suggests that the neural computations that contribute to facial expression recognition in each region are functionally distinct.
Increasing the Dissolution Rate of a Low-Solubility Drug Through a Crystalline-Amorphous Transition: A Case Study with Indomethicin

The purpose of this research is to further the understanding of the crystalline to amorphous phase transition (amorphization) that occurs when some crystalline drugs are dry blended with porous adsorbents. Indomethacin (IMC) and three grades of silica gel (SGs) were used in the study. Amorphization of crystalline IMC occurs rapidly during dry mixing with SG and was independent of mixing intensity and time. Extent of amorphization increases with lower ratios of IMC:SG and with decreased IMC and SG particle size. Blocking H-bonding silanol groups on SG by chemical modification reduced the extent of amorphization. IMC-SG mixtures showed improved dissolution rates over crystalline IMC, the improvement being directly related to the extent of amorphization. To preserve the improved dissolution rate, mixtures should be protected from moisture and heat. This approach holds promise as a mean of improving the dissolution rate of sparingly soluble drugs such as IMC.
Inhibition of Endoplasmic Reticulum-associated Degradation Rescues Native Folding in Loss of Function Protein Misfolding Diseases

Background: Lysosomal storage disorders are caused by ER-associated degradation (ERAD) of mutated unstable lysosomal enzymes. Results: ERAD inhibition enhances folding and activity of unstable lysosomal protein by prolonging ER retention. Conclusion: ERAD is the rate-limiting step in the folding of mutated lysosomal proteins. Significance: ERAD inhibition ameliorates the progression of multiple lysosomal storage disorders caused by protein misfolding and degradation. Lysosomal storage disorders are often caused by mutations that destabilize native folding and impair trafficking of secretory proteins. We demonstrate that endoplasmic reticulum (ER)-associated degradation (ERAD) prevents native folding of mutated lysosomal enzymes in patient-derived fibroblasts from two clinically distinct lysosomal storage disorders, namely Gaucher and Tay-Sachs disease. Prolonging ER retention via ERAD inhibition enhanced folding, trafficking, and activity of these unstable enzyme variants. Furthermore, combining ERAD inhibition with enhancement of the cellular folding capacity via proteostasis modulation resulted in synergistic rescue of mutated enzymes. ERAD inhibition was achieved by cell treatment with small molecules that interfere with recognition (kifunensine) or retrotranslocation (eeyarestatin I) of misfolded substrates. These different mechanisms of ERAD inhibition were shown to enhance ER retention of mutated proteins but were associated with dramatically different levels of ER stress, unfolded protein response activation, and unfolded protein response-induced apoptosis.
Regulation and Welfare: Evidence from Paragraph IV Generic Entry in the Pharmaceutical Industry

With increasing frequency, generic drug manufacturers in the United States are able to challenge the monopoly status of patent-protected drugs even before their patents expire. The legal foundation for these challenges is found in Paragraph IV of the Hatch-Waxman Act. If successful, these Paragraph IV challenges generally lead to large market share losses for incumbents and sharp declines in average market prices. This paper estimates, for the first time, the welfare effects of accelerated generic entry via these challenges. Using aggregate brand level sales data between 1997 and 2008 for hypertension drugs in the U.S. we estimate demand using a nested logit model in order to back out cumulated consumer surplus, which we find to be approximately $270 billion. We then undertake a counterfactual analysis, removing the stream of Paragraph IV facilitated generic products, finding a corresponding cumulated consumer surplus of $177 billion. This implies that gains flowing to consumers as a result of this regulatory mechanism amount to around $92 billion or about $133 per consumer in this market. These gains come at the expense to producers who lose, approximately, $14 billion. This suggests that net short-term social gains stands at around $78 billion. We also demonstrate significant cross-molecular substitution within the market and discuss the possible appropriation of consumer rents by the insurance industry. Policy and innovation implications are also discussed.
Formal Checking of Multiple Firewalls

When enterprises deploy multiple firewalls, a packet may be examined by different sets of firewalls. It has been observed that the resulting complex firewall network is highly error prone and causes serious security holes. Hence, automated solutions are needed in order to check its correctness. In this paper, we propose a formal and automatic method for checking whether multiple firewalls react correctly with respect to a security policy given in a high level declarative language. When errors are detected, some useful feedback is returned in order to correct the firewall configurations. Furthermore, we propose a priority-based approach to ensure that no incoherencies exist within the security policy. We show that our method is both correct and complete. Finally, it has been implemented in a prototype of verifier based on a satisfiability solver modulo theories. Experiment conducted on relevant case studies demonstrates the efficiency of our approach.
Internet of Vulnerable Things (IoVT): Detecting Vulnerable SOHO Routers

There has been a rampant surge in compromise of consumer grade small scale routers in the last couple of years. Attackers are able to manipulate the Domain Name Space (DNS) settings of these devices hence making them capable of initiating different man-in-the-middle attacks. By this study we aim to explore and comprehend the current state of these attacks. Focusing on the Indian Autonomous System Number (ASN) space, we performed scans over 3 months to successfully find vulnerable routers and extracted the DNS information from these vulnerable routers. In this paper we present the methodology followed for scanning, a detailed analysis report of the information we were able to collect and an insight into the current trends in the attack patterns. We conclude by proposing recommendations for mitigating these attacks.
A contingent model for the role of management support in IS implementation: a meta-analysis

Management support is considered critical for the successful implementation of IS innovations (Jarvenpaa and Ives 1991; Sauer 1993). Inconsistent with this, a number of studies report null findings for the effect of management support (Fuerst and Cheney 1982; Leonard-Barton and Deschamps 1988). This research proposes to resolve this inconsistency between theory and empirical findings. Drawing upon the context contingent model of implementation proposed by Yetton et al. (1997), it is hypothesized that management support is more important to successful implementation in high task interdependence contexts than in low task interdependence contexts.
Internet Engineering Task Force (ietf) Framework for Loop-free Convergence Using the Ordered Forwarding Information Base (ofib) Approach

This document describes an illustrative framework of a mechanism for use in conjunction with link-state routing protocols that prevents the transient loops that would otherwise occur during topology changes. It does this by correctly sequencing the forwarding information base (FIB) updates on the routers. This mechanism can be used in the case of non-urgent (management action) link or node shutdowns and restarts or link metric changes. It can also be used in conjunction with a fast reroute mechanism that converts a sudden link or node failure into a non-urgent topology change. This is possible where a complete repair path is provided for all affected destinations. After a non-urgent topology change, each router computes a rank that defines the time at which it can safely update its FIB. A method for accelerating this loop-free convergence process by the use of completion messages is also described. The technology described in this document has been subject to extensive simulation using pathological convergence behavior and real network topologies and costs. However, the mechanisms described in this document are purely illustrative of the general approach and do not constitute a protocol specification. This document represents a snapshot of the work of the Routing Area Working Group at the time of publication and is published as a document of record. Further work is needed before implementation or deployment. (IETF). It represents the consensus of the IETF community. It has received public review and has been approved for publication by the Internet Engineering Steering Group (IESG). Not all documents approved by the IESG are a candidate for any level of Internet Standard; see Section 2 of RFC 5741. Information about the current status of this document, any errata, and how to provide feedback on it may be obtained at in effect on the date of publication of this document. Please review these documents carefully, as they describe your rights and restrictions with respect to this document. Code Components extracted from this document must include Simplified BSD License text as described in Section 4.e of the Trust Legal Provisions and are provided without warranty as described in the Simplified BSD License.
Suppression of β3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis

ABSTRACT Anti-angiogenic treatments against αvβ3-integrin fail to block tumour growth in the long term, which suggests that the tumour vasculature escapes from angiogenesis inhibition through αvβ3-integrin-independent mechanisms. Here, we show that suppression of β3-integrin in mice leads to the activation of a neuropilin-1 (NRP1)-dependent cell migration pathway in endothelial cells via a mechanism that depends on NRP1's mobilisation away from mature focal adhesions following VEGF-stimulation. The simultaneous genetic targeting of both molecules significantly impairs paxillin-1 activation and focal adhesion remodelling in endothelial cells, and therefore inhibits tumour angiogenesis and the growth of already established tumours. These findings provide a firm foundation for testing drugs against these molecules in combination to treat patients with advanced cancers. Summary: Targeting both β3-integrin and neuropilin-1 prevents anti-angiogenic treatment escape.