Miracle-dz/UniFAR-FTUs huggingface dataset:
Sequential preoperative or postoperative docetaxel added to preoperative doxorubicin plus cyclophosphamide for operable breast cancer:National Surgical Adjuvant Breast and Bowel Project Protocol B-27.

PURPOSE This study was designed to determine the effect of adding docetaxel (T) to preoperative doxorubicin and cyclophosphamide (AC) on breast cancer response rates and disease-free survival (DFS) and overall survival (OS). PATIENTS AND METHODS Women with operable breast cancer (N = 2,411) were randomly assigned to receive preoperative AC followed by surgery, AC followed by T and surgery, or AC followed by surgery and then T. Tamoxifen was initiated concurrently with chemotherapy. Median time on study for 2,404 patients with follow-up was 77.9 months. RESULTS Addition of T to AC did not significantly impact DFS or OS. There were trends toward improved DFS with addition of T. The addition of T reduced the incidence of local recurrences as first events (P = .0034). Preoperative T, but not postoperative T, significantly improved DFS in patients who had a clinical partial response after AC (hazard ratio [HR] = 0.71; 95% CI, 0.55 to 0.91; P = .007). Pathologic complete response, which was doubled by addition of preoperative T, was a significant predictor of OS regardless of treatment (HR = 0.33; 95% CI, 0.23 to 0.47; P < .0001). Pathologic nodal status after chemotherapy was a significant predictor of OS (P < .0001). CONCLUSION The addition of preoperative or postoperative T after preoperative AC did not significantly affect OS, slightly improved DFS, and decreased the incidence of local recurrences. The sample size of this study was not sufficient to yield significance for the moderate DFS improvement. Concurrent use of tamoxifen may have limited the impact of adding T.
The relative involvement of Th1 and Th2 associated immune responses in the expulsion of a primary infection of Heligmosomoides polygyrus in mice of differing response phenotype

Abstract T helper cell (Th1 and Th2) associated responses were examined following a primary infection with the gastrointestinal nematode Heligmosomoides polygyrus in five inbred strains of mice with different resistance phenotypes. Levels of (i) mast cell protease, (ii) specific IgE, (iii) nitric oxide and (iv) specific IgG2a, as markers of Th2 and Th1 associated responses, respectively, were determined in sera and intestinal fluids and correlated with worm burdens. The ‘fast’ responder (resistant) strains SWR and SJL produced strong Th2 and Th1 associated responses respectively in a mutually exclusive fashion. The F1 hybrid (SWR×SJL) F1, showed rapid expulsion of the parasite and expressed both intense Th1 and Th2 responses, suggesting synergism between Th1 and Th2 activity in these mice. The results indicate that both Th2 and Th1 responses operate in mice following a primary infection with H. polygyrus and that each Th response may be involved to a greater or lesser degree within certain strains. Resistance to H. polygyrus was found to correlate only to the intensity of either the gut-associated mastocytosis or nitric oxide production in these strains but not to either specific IgE or IgG2a titres. Chronic infections in the ‘slow’ response phenotype mouse strains CBA and C57BL/10, were associated with both poor Th2 and poor Th1-associated responses attributed to a general parasite-mediated immunosuppression of the host immune response to infection.
Personalized Fuzzy Text Search Using Interest Prediction and Word Vectorization

In this paper we study the personalized text search problem. The keyword based search method in conventional algorithms has a low efficiency in understanding users' intention since the semantic meaning, user profile, user interests are not always considered. Firstly, we propose a novel text search algorithm using a inverse filtering mechanism that is very efficient for label based item search. Secondly, we adopt the Bayesian network to implement the user interest prediction for an improved personalized search. According to user input, it searches the related items using keyword information, predicted user interest. Thirdly, the word vectorization is used to discover potential targets according to the semantic meaning. Experimental results show that the proposed search engine has an improved efficiency and accuracy and it can operate on embedded devices with very limited computational resources.
Accumulative Roll Bonding of AA8006, AA8011 and AA5754 Sheets

Accumulative Roll Bonding (ARB) is a technique of grain refinement by severe plastic deformation, which involves multiple repetitions of surface treatment, stacking, rolling, and cutting. The rolling with 50% reduction in thickness bonds the sheets. After several cycles, ultrafine-grained (UFG) materials are produced. Since ARB enables the production of large amounts of UFG materials, its adoption into industrial practice is favoured. ARB has been successfully used for preparation of UFG sheets from different ingot cast aluminium alloys. Twin-roll casting (TRC) is a cost and energy effective method for manufacturing aluminium sheets. Fine particles and small grain size are intrinsic for TRC sheets making them good starting materials for ARB. The paper presents the results of a research aimed at investigating the feasibility of ARB processing of three TRC alloys, AA8006, AA8011 and AA5754, at ambient temperature. The microstructure and properties of the ARB were investigated by means of light and transmission electron microscopy and hardness measurements. AA8006 specimens were ARB processed without any problems. Sound sheets of AA8011 alloy were also obtained even after 8 cycles of ARB. The AA5754 alloy suffered from severe edge and notch cracking since the first cycle. The work hardening of AA8006 alloy saturated after the 3rd cycle, whereas the hardness of AA5754 alloy increased steadily up to the 5th cycle. Monotonous increase in strength up to 280 MPa was observed in the ARB processed AA8011 alloy.
Bandwidth and Latency Requirements for Smart Transmission Grid Applications

The rapid increase of phasor measurements on the high voltage power system has opened opportunities for new applications to enhance the operation of the grid. To take advantage of the high sampling rates of these measurement data, these applications will require a high-bandwidth, networked communication system. The specifications for this next generation communication system that will overlay the continental power grids are under intense discussion at this time by organizations like the North-American Synchro-Phasor Initiative (NASPI). In this paper we present a method to simulate, design and test the adequacy of a communication system for a particular transmission grid. The main difference from typical communication system studies is that we formulate the communication requirements from the power grid application requirements, that is, the communication design, simulation and testing is from the viewpoint of the anticipated power applications. The method is demonstrated on a WECC 225 bus and a Polish 2383 bus transmission system models.
Identification of androgen‐responsive genes that are alternatively regulated in androgen‐dependent and androgen‐independent rat prostate tumors

The vast majority of androgen‐dependent prostate tumors progress toward incurable, androgen‐independent tumors. The identification of androgen‐responsive genes, which are still actively transcribed in the tumors of patients who have undergone androgen ablation, may shed light on the molecular mechanisms underlying this phenomenon. To address this question, we chose the Dunning R3327 rat model system, in which the progression from androgen‐dependent to ‐independent tumors is represented by several transplantable prostate‐derived tumors. Gene expression profiles were analyzed in normal rat prostates and in the prostates of rats 14 days after castration by use of microarrays containing approximately 5,000 oligonucleotides, together representing more than 4,800 known rat genes. These expression profiles were compared with similarly obtained expression profiles of androgen‐dependent and androgen‐independent rat prostate tumors. By doing so, a series of known and novel prostate cancer–associated androgen‐responsive genes was identified. Within this series, we were able to identify several clusters of genes that are differentially regulated in the various prostate tumors. These genes may serve as (i) novel prognostic identifiers and (ii) novel therapeutic targets. © 2005 Wiley‐Liss, Inc.
An optimized β‐tricalcium phosphate and agarose scaffold fabrication technique

Biodegradable scaffolds composed of β-tricalcium phosphate, and a natural hydrogel, agarose, were prepared by a shaping method based on the thermal gelation of the polymeric component. This technique was modified to facilitate the inclusion, during the scaffold preparation stage, of therapeutic agents that could improve the graft performance. Vancomycin was included in materials containing different amounts of agarose and ceramic without affecting the scaffold consolidation process. These materials, easily injectable, behave like a reinforced hydrogel whose swelling behavior and drug release rate depend on their composition. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
Creamatocrit Analysis of Human Milk Overestimates Fat and Energy Content When Compared to a Human Milk Analyzer Using Mid-infrared Spectroscopy

Background and Objective: Human milk (HM) is the preferred feeding for human infants but may be inadequate to support the rapid growth of the very-low-birth-weight infant. The creamatocrit (CMCT) has been widely used to guide health care professionals as they analyze HM fortification; however, the CMCT method is based on an equation using assumptions for protein and carbohydrate with fat as the only measured variable. The aim of the present study was to test the hypothesis that a human milk analyzer (HMA) would provide more accurate data for fat and energy content than analysis by CMCT. Methods: Fifty-one well-mixed samples of previously frozen expressed HM were obtained after thawing. Previously assayed “control” milk samples were thawed and also run with unknowns. All milk samples were prewarmed at 40°C and then analyzed by both CMCT and HMA. CMCT fat results were substituted in the CMCT equation to reach a value for energy (kcal/oz). Fat results from HMA were entered into a computer model to reach a value for energy (kcal/oz). Fat and energy results were compared by paired t test with statistical significance set at P < 0.05. An additional 10 samples were analyzed locally by both methods and then sent to a certified laboratory for quantitative analysis. Results for fat and energy were analyzed by 1-way analysis of variance with statistical significance set at P < 0.05. Results: Mean fat content by CMCT (5.8 ± 1.9 g/dL) was significantly higher than by HMA (3.2 ± 1.1 g/dL, P < 0.001). Mean energy by CMCT (21.8 ± 3.4 kcal/oz) was also significantly higher than by HMA (17.1 ± 2.9, P < 0.001). Comparison of biochemical analysis with HMA of the subset of milk samples showed no statistical difference for fat and energy, whereas CMCT was significantly higher than for both fat (P < 0.001) and energy (P = 0.002). Conclusions: The CMCT method appears to overestimate fat and energy content of HM samples when compared with HMA and biochemical methods.
Dynamic Tree Cross Products Preprint

Range searching over tree cross products is a variant of classic range searching, recently introduced by Buchsbaum et al. (Proc. 8th ESA, vol. 1879 of LNCS, pp. 120–131, 2000). A tree cross product consist of hyperedges connecting the nodes of trees T1, . , Td. In this context, range searching means to determine all hyperedges connecting a given set of tree nodes. Buchsbaum et al. describe a data structure which supports, besides queries, adding and removing of edges; the tree nodes remain fixed. In this paper we present a new data structure, which additionally provides insertion and deletion of leaves of T1, . , Td; it combines the former approach with a novel technique of using search trees superimposed over ordered list maintenance structures. The extra cost for this dynamization is roughly a factor of O(log n/log log n). The trees being dynamic is especially important for maintaining hierarchical graph views, a problem that can be modeled as tree cross product. Such views evolve from a large base graph by the contraction of subgraphs defined recursively by an associated hierarchy. The graph view maintenance problem is to provide methods for refining and coarsening a view. In previous solutions only the edges of the underlying graph were dynamic; with the application of our data structure, the node set becomes dynamic as well.
Model-Driven Plug-in Development for UML Based Modeling Systems. Information Technology and Control

UML is the main modeling language used in model-driven development (MDD). In many cases, UML-based modeling systems need to be extended by plug-ins to support different modeling approaches. This paper proposes a conceptual framework for model-driven development of plug-ins, which enables reuse of UML modeling capabilities for defining executable plug-in models. This approach suggests that UML-based modeling system should provide for their users a set of extension profiles that make up Application Modeling Interface (AMI), which is MDD alternative to Application Programming Interface (API). The paper describes three cases of AMI - model validation, methodology wizards, and model patterns - and sample plug-in models based on them. The presented samples are implemented in MagicDraw, which is one of the most popular UML-based modeling systems worldwide. The paper also discusses the benefits and drawbacks of the proposed approach and its further research directions. http://dx.doi. org/10.5755/j01.itc. 40.3. 627
Online View Maintenance for Continuous Query Evaluation

In Web stream processing, there are queries that integrate Web data of various velocity, categorized broadly as streaming (i.e., fast changing) and background (i.e., slow changing) data. The introduction of local views on the background data speeds up the query answering process, but requires maintenance processes to keep the replicated data up-to-date. In this work, we study the problem of maintaining local views in a Web setting, where background data are usually stored remotely, are exposed through services with constraints on the data access (e.g., invocation rate limits and data access patterns) and, contrary to the database setting, do not provide streams with changes over their content. Then, we propose an initial solution: WBM, a method to maintain the content of the view with regards to query and user-defined constraints on accuracy and responsiveness.
Preliminary Evidence of Validity of the Revised Criteria for Alzheimer Disease Diagnosis: Report of 2 Cases

ObjectiveRevised research criteria for the diagnosis of Alzheimer disease have been proposed to capture patients presenting with mild and not yet disabling symptoms, and currently classified as mild cognitive impairment (MCI). We describe 2 very mild cases of MCI and their clinical outcome. MethodsThe 2 cases were selected as they had unequivocal preservation of daily activities and normal global cognitive performance (Mini-Mental State Examination 29/30) and were positive to all 3 markers. Cognitive profile was assessed with an extensive neuropsychologic battery, medial temporal atrophy with hippocampal volumetry, hypometabolism on 18F-deoxyglucose positron emission tomography and voxel-based statistical parametric mapping analysis, and tau and amyloid beta-42 in the cerebrospinal fluid with enzyme-linked immunosorbent assay. ResultsBoth patients had a poor performance in 2 out of 11 neuropsychologic tests. Both had hippocampal volumes at or below the first percentile of the age-specific distribution, retrosplenial glucose hypometabolism, and inversion of tau/amyloid beta-42 cerebrospinal fluid ratio. Both showed progression of the cognitive deficit over the following 12 months. ConclusionsThese 2 patients with progressive MCI and positivity to all Alzheimer markers predicated by the new research criteria provide preliminary support to their validity. Future work will characterize the marker profile of the vast majority of patients with incomplete marker positivity.
Electroactive Polymers for Robotic Applications: Artificial Muscles and Sensors

Electroactive polymers (EAPs) respond to electrical stimulation with large deformations. They are dynamic actuators which have attracted attention from an interdisciplinary audience of engineers and scientists. An enabling EAP technology is emerging which attempts to imitate the properties of natural muscle and which, as a result, can perform a unique function in a variety of biologically-inspired robotics applications. Electroactive Polymers for Robotics Applications covers the fundamental properties, modelling and demonstration of EAPs in robotic applications, focusing particularly on artificial muscles and sensors. Ionic PolymerMetal Composite Actuators and Dielectric Elastomers are discussed within the book with chapters on their properties and their uses in robotics applications. With its concentration on devices based on EAPs and their uses, Electroactive Polymers for Robotics Applications will be of interest to researchers working within this field as well as to postgraduate students studying robotics or smart materials and structures. Practitioners working in the mechanical, electrical and materials industries will also find this book of value.
On Finding Exciting Trajectories for Identification Experiments Involving Systems with Nonlinear Dynamics

When designing an identification experiment for a system described by nonlinear functions such as those of manipulator dynamics, it is necessary to consider whether the excitation is sufficient to provide an accurate estimate of the parameters in the presence of experimental noise. It is shown that the convergence rate and noise immunity of a parameter identifi cation experiment depend directly on the condition number of the input correlation matrix, a measure of excitation. The sensitivity of an identification experiment to unmodeled dynamics is also studied; a dimensionless measure of this sensitivity—bias susceptibility—is proposed and related to excitation. The issue of how exciting a trajectory may be is addressed, and a method is presented to maximize the exci tation. Two identification experiments reported in the litera ture are studied; analysis of these experiments shows that intuitively selected trajectories may provide poor excitation, and considerable improvement results from employing the optimization to maximize excitation. A typical improvement is the reduction of parameter convergence time from 15 min to 33 s. This work illustrates the difficulty of maintaining persistent excitation during the experimental identification of complex models.
Initial Status in Growth Curve Modeling for Randomized Trials

The growth curve modeling (GCM) technique has been widely adopted in longitudinal studies to investigate progression over time. The simplest growth profile involves two growth factors, initial status (intercept) and growth trajectory (slope). Conventionally, all repeated measures of outcome are included as components of the growth profile, and the first measure is used to reflect the initial status. Selection of the initial status, however, can greatly influence study findings, especially for randomized trials. In this article, we propose an alternative GCM approach involving only post-intervention measures in the growth profile and treating the first wave after intervention as the initial status. We discuss and empirically illustrate how choices of initial status may influence study conclusions in addressing research questions in randomized trials using two longitudinal studies. Data from two randomized trials are used to illustrate that the alternative GCM approach proposed in this article offers better model fitting and more meaningful results.
The origin of [Fe ii] emission in NGC 4151

The centre of NGC 4151 has been observed in the J band with the SMIRFS integral field unit (IFU) on the UK Infrared Telescope. A map of [Fe ii] emission is derived, and compared with the distributions of the optical narrow-line region and radio jet. We conclude that, because the [Fe ii] emission is associated more closely with the visible narrow-line region than with the radio jet, it arises mainly through photoionization of gas by collimated X-rays from the Seyfert nucleus. The velocity field and strength with respect to Paβ are found to be consistent with this argument. The performance of the IFU is considered briefly, and techniques for observation and data analysis are discussed.
AN EVALUATION OF THE NON-LINEAR VISCOELASTIC PROPERTIES OF THE HEALING MEDIAL COLLATERAL LIGAMENT

Injuries to knee ligaments are frequent, demanding an increased understanding of the healing process. Clinically, the injured medial collateral ligament (MCL) has been found to heal without surgical intervention. However, laboratory studies have shown that, even one year after injury, the biomechanical properties, biochemical composition, and histomorphological appearance of the healing MCL remains suboptimal. While research has focused on the changes in mechanical properties (i.e. stress-strain behavior) of the healed MCL, studies on its viscoelastic properties are limited. Yet, this knowledge is critical to determine the overall kinetic response of the knee joint.The quasi-linear viscoelastic (QLV) theory proposed by Professor Y.C. Fung has been frequently used to model the viscoelastic properties of the MCL. This theory was developed based on an idealized step-elongation during a stress relaxation test. As this is experimentally impossible, the constants of the theory may not be representative when they are determine based on experiments that utilize finite strain rates. Thus, the overall objectives of this dissertation were to 1) develop and validate a novel experimental and analytical approach that accounts for finite strain rates and provides an accurate determination of the viscoelastic properties of the normal MCL, 2) apply this new approach to describe the viscoelastic behavior of the healing MCL, and 3) to determine whether the new approach can describe the response of the MCL to harmonic oscillations.This work demonstrated that a newly developed approach could be utilized to determine the constants of the quasi-linear viscoelastic theory and successfully describe the viscoelastic behavior of both the normal and healing MCLs. Interestingly, the healing ligaments display a lower initial slope of the stress-strain curve and a greater propensity to dissipate energy, suggesting other structures within the knee would have to play a compensatory role in knee function. It was also found that the mechanisms governing the viscoelastic response of the MCL to harmonic oscillations may not be the same as that which governs stress relaxation behavior. Thus, a more general theory may be necessary to describe both phenomena.