Miracle-dz/UniFAR-FTUs huggingface dataset:
Staging of Hepatic Fibrosis: Comparison of Magnetic Resonance Elastography and Shear Wave Elastography in the Same Individuals

Objective To cross-validate liver stiffness (LS) measured on shear wave elastography (SWE) and on magnetic resonance elastography (MRE) in the same individuals. Materials and Methods We included 94 liver transplantation (LT) recipients and 114 liver donors who underwent either MRE or SWE before surgery or biopsy. We determined the technical success rates and the incidence of unreliable LS measurements (LSM) of SWE and MRE. Among the 69 patients who underwent both MRE and SWE, the median and coefficient of variation (CV) of the LSM from each examination were compared and correlated. Areas under the receiver operating characteristic curve in both examinations were calculated in order to exclude the presence of hepatic fibrosis (HF). Results The technical success rates of MRE and SWE were 96.4% and 92.2%, respectively (p = 0.17), and all of the technical failures occurred in LT recipients. SWE showed 13.1% unreliable LSM, whereas MRE showed no such case (p < 0.05). There was moderate correlation in the LSM in both examinations (r = 0.67). SWE showed a significantly larger median LSM and CV than MRE. Both examinations showed similar diagnostic performance for excluding HF (Az; 0.989, 1.000, respectively). Conclusion MRE and SWE show moderate correlation in their LSMs, although SWE shows higher incidence of unreliable LSMs in cirrhotic liver.
Vapor-liquid equilibria of the two-dimensional Lennard-Jones fluid(s)

Monte Carlo simulations in the Gibbs ensemble are presented for the two‐dimensional Lennard‐Jones fluids. We have considered the full Lennard‐Jones potential and the truncated (at 2.5σ) and shifted potential. It is shown that the critical temperature depends largely on the details of the truncation of the potential. These differences are by no means small.
Reopening the debate on radiation exposure in the PICU.

REFERENCES 1. Domico MB, Ridout DA, Bronicki R, et al: The impact of mechanical ventilation time before initiation of extracorporeal life support on survival in pediatric respiratory failure: A review of the Extracorporeal Life Support Registry. Pediatr Crit Care Med 2012; 13:16–21 2. Peek GJ, Mugford M, Tiruvoipati R, et al; CESAR trial collaboration: Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): A multicentre randomised controlled trial. Lancet 2009; 374:1351–1363 DOI: 10.1097/PCC.0b013e31826e83a3
A Rapid Prototyping Technique for Microfluidics with High Robustness and Flexibility

In microfluidic device prototyping, master fabrication by traditional photolithography is expensive and time-consuming, especially when the design requires being repeatedly modified to achieve a satisfactory performance. By introducing a high-performance/cost-ratio laser to the traditional soft lithography, this paper describes a flexible and rapid prototyping technique for microfluidics. An ultraviolet (UV) laser directly writes on the photoresist without a photomask, which is suitable for master fabrication. By eliminating the constraints of fixed patterns in the traditional photomask when the masters are made, this prototyping technique gives designers/researchers the convenience to revise or modify their designs iteratively. A device fabricated by this method is tested for particle separation and demonstrates good properties. This technique provides a flexible and rapid solution to fabricating microfluidic devices for non-professionals at relatively low cost.
Hamiltonian Formulation of Heat Conduction : Integral Transform Method Approach

The mathematical description of physical systems makes often use of the Hamiltonian formalism, which from its original application to derive the so-called Hamilton’s equations of motion in classical mechanics quickly spread on many other physical phenomena, ranging from statistical physics to quantum mechanics [1]. Although the Hamiltonian formulation of a problem of mathematical physics in general does not simplify the search for a solution, very often it provides a better insight of physical phenomena and reveals analogies which may remain hidden when using other formulations.
Spitzer 24 Micron Observations of Optical/Near-Infrared-Selected Extremely Red Galaxies: Evidence for Assembly of Massive Galaxies at z ∼ 1-2?

We carried out direct measurement of the fraction of dusty sources in a sample of extremely red galaxies with (R - Ks) ≥ 5.3 mag and Ks < 20.2 mag, using 24 μm data from the Spitzer Space Telescope. Combining deep 24 μm Ks- and R-band data over an area of ∼64 arcmin2 in ELAIS N1 of the Spitzer First Look Survey (FLS), we find that 50% ± 6% of our extremely red object (ERO) sample have measurable 24 μm flux above the 3 σ flux limit of 40 μJy. This flux limit corresponds to a star formation rate (SFR) of 12 M⊙ yr-1 at z ∼ 1, much more sensitive than any previous long-wavelength measurement. The 24 μm-detected EROs have 24 μm/2.2 μm and 24 μm/0.7 μm flux ratios consistent with infrared luminous, dusty sources at z ≥ 1, and are an order of magnitude too red to be explained by an infrared quiescent spiral or a pure old stellar population at any redshift. Some of these 24 μm-detected EROs could be active galactic nuclei; however, the fraction among the whole ERO sample is probably small, 10%-20%, as suggested by deep X-ray observations as well as optical spectroscopy. Keck optical spectroscopy of a sample of similarly selected EROs in the FLS field suggests that most of the EROs in ELAIS N1 are probably at z ∼ 1. The mean 24 μm flux (167 μJy) of the 24 μm-detected ERO sample roughly corresponds to the rest-frame 12 μm luminosity, νLν(12 μm), of 3 × 1010 L⊙ at z ∼ 1. Using the correlation between IRAS νLν(12 μm) and infrared luminosity LIR(8-1000 μm), we infer that the of the 24 μm-detected EROs is 3 × 1011 and 1 × 1012 L⊙ at z = 1.0 and 1.5, respectively, similar to that of local luminous infrared galaxies (LIRGs) and ultraluminous infrared galaxies (ULIRGs). The corresponding SFR would be roughly 50-170 M⊙ yr-1. If the timescale of this starbursting phase is on the order of 108 yr as inferred for the local LIRGs and ULIRGs, the lower limit on the masses of these 24 μm-detected EROs is 5 × 109 to 2 × 1010 M⊙. It is plausible that some of the starburst EROs are in the midst of a violent transformation to become massive early type galaxies at the epoch of z ∼ 1-2.
Podocyte Foot Process Effacement in Postreperfusion Allograft Biopsies Correlates With Early Recurrence of Proteinuria in Focal Segmental Glomerulosclerosis

Background Focal segmental glomerulosclerosis (FSGS) is a relatively prevalent glomerular disorder that often progresses to end-stage renal disease. Thirty to 80% of kidney transplant (KT) recipients with FSGS will experience recurrence characterized by proteinuria and podocyte damage. We hypothesized that the degree of podocyte foot process (FP) effacement in postreperfusion transplant biopsies can be used to predict the development of clinical recurrence of FSGS. Method Nineteen pairs of pre- and postreperfusion biopsy specimens were studied. We evaluated the degree of FP effacement in postreperfusion KT biopsies by counting the number of widened FP per capillary loop. Early recurrence of FSGS was defined as development of nephrotic range proteinuria between days 3 and 30 posttransplant. Results Early recurrence occurred in 7 of 19 grafts (36.8%) at a mean of 4.29±1.89 days. The mean score of FP effacement in postreperfusion allograft biopsies was 0.72±0.31 and 1.35±0.63 in the nonrecurrent and recurrent group, respectively (P=0.039). There was an association between FP effacement and proteinuria (P = 0.04). The FP effacement score predicts early recurrence with a sensitivity of 71.4% and specificity of 91.7%. Conclusion FP effacement can be observed within minutes after reperfusion in renal transplantation of recipients with FSGS that will ultimately develop recurrent FSGS. This suggests a key role for the podocyte injury in the pathogenesis of recurrent FSGS and further supports the presence of circulating factors causing FP effacement. The FP effacement score in the postreperfusion KT biopsy may become a useful predictive test if validated in larger studies.
Temporal artifacts in flat dynamic x-ray detectors

Flat X-ray detectors based on CsI:Tl scintillators and amorphous silicon photodiodes are known to exhibit temporal artefacts (ghost images) which decay over time. Previously, these temporal artefacts have been attributed mainly to residual signals from the amorphous silicon photodiodes. More detailed experiments presented here show that a second class of effects, the so-called gain effects, also contributes significantly to the observed temporal artefacts. Both the residual signals and the photodiode gain effect have been characterized under various exposure conditions in the study presented here. The results of the experiments quantitatively show the decay of the temporal artefacts. Additionally, the influence of the detector's reset light on both effects in the photodiode has been studied in detail. The data from the measurements is interpreted based on a simple trapping model which suggests a strong link between the photodiode residual signals and the photodiode gain effect. For the residual signal effect a possible correction scheme is described. Furthermore, the relevance of the remaining temporal artefacts for the applications is briefly discussed for both the photodiode residual signals and the photodiode gain effect.
EATING DISORDERS AND SUICIDE RISK FACTORS IN ADOLESCENTS: AN IRTALIAN COMMUNITY-BASED STUDY

In a mixed male-female sample of 1000 adolescents age 15 to 19 years in a northeastern area of Italy, we investigated the links between eating disorders and suicidal tendencies by means of self-compiled measures, including the Eating Attitudes Test (EAT), the Bulimic Investigatory Test of Edinburgh (BITE), the Body Attitudes Test (BAT), and the SCL-90-R. More females than males reported abnormal eating patterns suggesting eating disorders: we found that 100 females (15.8%) and 8 males (2.8%) achieved scores above the suggested cutoff on EAT (cutoff = 30), 26 females (4.1%) and 1 male (.3%) achieved scores above the suggested cutoff on BITE (cutoff = 20), and 287 females (45.5%) and 24 males (8.6%) achieved scores above the suggested cutoff on BAT (cutoff = 36). More females than males also reported symptoms of hopelessness (44.3%vs. 30.5%) and suicidal ideation (30.8%vs. 25.3%). Both males and females reporting suicidal ideation achieved significantly higher scores on the eating disorders inventories, with no independent contribution by age, socioeconomic status, or body mass index. Although caution is required when drawing conclusions from self-reported measures, studies on mood disorders and suicidality in youth clearly need to include measures of eating disorders.
Development of SCRIS: A Knowledge Based System Tool for Assisting Organizations in Managing Supply Chain Risks

Today’s Supply Chain (SC) network is operating in ever more complex and dynamic environments due to globalization, rapid technology development, more demanding customers, more sophisticated products/services and tougher competition. Outsourcing, smaller supply base, zero inventory and other approaches have been seen as enablers for handling these business challenges. However, these approaches make SC turn into a more complex and interdependent network which increases SC vulnerability to any disruption (risk). Supply Chain Risk Management (SCRM) is aiming at reducing SC network susceptibility. Risk identification is one of important step in SCRM. Most of the potential SC risks and most importantly their interrelationships should be recognized to ensure that organizations develop an appropriate SC risk mitigation strategy. Due to the nature and complexity of SC network, identifying risk becomes a highly challenging task for organizations. This paper presents the development of Knowledge Based - Supply Chain Risk Identification System (SCRIS) which gives assistance to organizations to manage risks in their SC network by recommending on two important issues: (1) SC potential risks, and (2) Interrelations of these potential risks.
Screening of Oropharynx and Anorectum Increases Prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae Infection in Female STD Clinic Visitors

Background: The relevance of screening of oropharynx and anorectum in addition to endocervical tests for detection of Chlamydia trachomatis and Neisseria gonorrhoeae infection is unclear in women, while there is a documented benefit of this approach in men who have sex with men. Methods: Female visitors to the sexually transmitted disease (STD) clinic were asked about their sexual practice as a part of the routine electronic patient file. In addition to tests for endocervical infection, swabs were taken from the oropharynx and anorectum to test for C. trachomatis and N. gonorrhoeae based on the history of sexual contact. Routinely, all electronic patient files are anonymously included in a database for surveillance purposes. In this observational study, we analyzed all consultations in the database over an 18 months period. Results: A total of 4299 consultations were registered; 10% of women had endocervical chlamydia and 1.1% had gonorrhea. The detection rates for C. trachomatis and N. gonorrhoeae from oropharyngeal samples were 1.9% and 0.8%, and from anorectal samples 8.7% and 1.7%, respectively. Except for 2 cases of pharyngeal gonorrhea, all oropharyngeal and anorectal infections were asymptomatic. Inclusion of oropharyngeal and anorectal tests in the screening protocol was associated with a percentage increase in prevalence of chlamydia by 9.5% and gonorrhea by 31%, relative to tests for endocervical tests alone. The percentage increase in prevalence was higher than that for the symptom-based approach (3.7% and 10.4%, respectively). Conclusions: Inclusion of oropharyngeal and anorectal tests in the STD screening protocol increases the prevalence of chlamydia and gonorrhea in women. Screening of anatomical sites based on sexual history is preferred over a symptom-based protocol.
Effects of interior bezels of tiled-monitor large displays on visual search, tunnel steering, and target selection

Tiled-monitor large displays are widely used in various application domains. However, how their interior bezels affect user performance and behavior has not been fully understood. We conducted three controlled experiments to investigate effects of tiled-monitor interior bezels on visual search, straight-tunnel steering, and target selection tasks. The conclusions of our paper are: 1) interior bezels do not affect visual search time nor error rate; however, splitting objects across bezels is detrimental to search accuracy, 2) interior bezels are detrimental to straight-tunnel steering, but not to target selection. In addition, we discuss how inte-rior bezels affect user behaviors, and suggest guidelines for effectively using tiled-monitor large displays and designing user interfaces suited to them.
Detecting Flaws Analysis of Q345qD Hot Rolled Steel Plate

Three different flaws were detected in a Q345qD hot rolled steel plate by ultrasonic test. The morphologies, chemical compositions and formation causes of these flaws were studied by using metallographic examination, Electron Probe Micros-analyzer (EPMA) and Energy Dispersive X-ray Spectrometer (EDS) analysis. Besides, some corrective measures were proposed to reduce the incidence rate of these detecting flaws.
Protocole expérimental pour la caractérisation de Modèles de Zones Cohésives thermomécaniques dédiés à la rupture dynamique des résines époxy

The field of this study is the dynamic fracture of epoxy resins which can exhibit very localised heating surrounding an high speed propagating crack tip. Although both crack speed and temperature are known to be parameters influencing the dynamic toughness of such glassy polymers, there are few cohesive models including this double dependency. Difficulties in collecting reliable experimental results are definitely involved. Therefore this article describes an experimental procedure dedicated to the characterisation of thermomechanical cohesive models based on the fracture energy value. Then the determination of the mode I dynamic energy release rate GIdyn by a strain gage method is described. In addition a thermocouple technique is coupled with a thermal analysis to evaluate the temperature at the crack tip Tf . Finally an experimental set-up is proposed to simultaneously and simply implement these measurements on the same epoxy specimen in association with high speed imaging for crack tracking. Mots clefs : Modeles de Zones Cohesives ; Rupture Dynamique ; Polymeres Renforces
Continuous top-k queries over real-time web streams. (Evaluation de requêtes top-k continues à large-échelle)

The Web has become a large-scale real-time information system forcing us to revise both how to effectively assess relevance of information for a user and how to efficiently implement information retrieval and dissemination functionality. To increase information relevance, Real-time Web applications such as Twitter and Facebook, extend content and social-graph relevance scores with " real-time " user generated events (e.g. re-tweets, replies, likes). To accommodate high arrival rates of information items and user events we explore a pub-lish/subscribe paradigm in which we index queries and update on the fly their results each time a new item and relevant events arrive. In this setting, we need to process continuous top-k text queries combining both static and dynamic scores. To the best of our knowledge, this is the first work addressing how non-predictable, dynamic scores can be handled in a continuous top-k query setting.
Lack of Dopaminergic Inputs Elongates the Primary Cilia of Striatal Neurons

In the rodent brain, certain G protein-coupled receptors and adenylyl cyclase type 3 are known to localize to the neuronal primary cilium, a primitive sensory organelle protruding singly from almost all neurons. A recent chemical screening study demonstrated that many compounds targeting dopamine receptors regulate the assembly of Chlamydomonas reinhardtii flagella, structures which are analogous to vertebrate cilia. Here we investigated the effects of dopaminergic inputs loss on the architecture of neuronal primary cilia in the rodent striatum, a brain region that receives major dopaminergic projections from the midbrain. We first analyzed the lengths of neuronal cilia in the dorsolateral striatum of hemi-parkinsonian rats with unilateral lesions of the nigrostriatal dopamine pathway. In these rats, the striatal neuronal cilia were significantly longer on the lesioned side than on the non-lesioned side. In mice, the repeated injection of reserpine, a dopamine-depleting agent, elongated neuronal cilia in the striatum. The combined administration of agonists for dopamine receptor type 2 (D2) with reserpine attenuated the elongation of striatal neuronal cilia. Repeated treatment with an antagonist of D2, but not of dopamine receptor type 1 (D1), elongated the striatal neuronal cilia. In addition, D2-null mice displayed longer neuronal cilia in the striatum compared to wild-type controls. Reserpine treatment elongated the striatal neuronal cilia in D1-null mice but not in D2-null mice. Repeated treatment with a D2 agonist suppressed the elongation of striatal neuronal cilia on the lesioned side of hemi-parkinsonian rats. These results suggest that the elongation of striatal neuronal cilia following the lack of dopaminergic inputs is attributable to the absence of dopaminergic transmission via D2 receptors. Our results provide the first evidence that the length of neuronal cilia can be modified by the lack of a neurotransmitter's input.
Enhancing Adherence to Cognitive Behavioral Therapy for Insomnia through Machine and Social Persuasion

Cognitive behavioral therapy for insomnia (CBT-I) is a treatment that focuses on psychological and behavioral factors. Although the CBT-I has proven efficacy, yet 32%-V89% of patients fail to consistently follow recommendations. The critical challenge of CBT-I is how to enhance the adherence of patients to therapy. In this study, we propose a persuasion method which integrates machine-generated persuasion and socially-generated persuasion for enhancing adherence, and we design a mobile application Win-Win ASleep (WWaS). We performed a 6-week study to evaluate the usability of WWaS on enhancing behavioral and recording adherence in comparison to a paper-based diary. Results show that machine-generated persuasion and socially-generated persuasion enhanced the adherence of patients in different manner, and WWaS assists users keeping a sleep diary accurate and complete. These higher quality records of sleep diary benefits the therapy. We also discuss strategies and provide recommendations for designing similar mobile applications to promote healthy behavior.
Differences in arm motion timing characteristics for basketball free throw and jump shooting via a body-worn sensorized sleeve

Arm motion timing is critical during basketball shooting. This study used a body-worn, sensorized basketball sleeve to identify arm motion timing characteristics during basketball free throw and jump shot shooting for trained and novice shooters. Current basketball shooting research has typically focused on arm kinematic angles, while shot timing has received comparatively less attention. An experiment was conducted to compare arm motion timing between trained and novice shooters while shooting free throws, and a second experiment compared arm motion timing between free throws and jump shots by trained shooters. Trained shooters shot free throws significantly faster than novice shooters, and trained shooters shot jump shots significantly faster than free throws at the same distance from the basket. Knowledge of arm motion timing characteristics from this study could enable future training for improved shooter accuracy.
Emerging role for complement in HIV infection.

PURPOSE OF REVIEW New evidence is provided that the complement system is not only an effective component of the innate immunity, but is also involved in bridging innate and adaptive immune response to control retroviral infections. RECENT FINDINGS The complement contributes to the control of retroviral replication by various strategies, such as complement-mediated lysis, triggering of B-cell responses by trapping the virus on follicular dendritic cells in the germinal center or enhancing of antigen presentation and thus the induction of virus-specific cytotoxic T lymphocytes. HIV has evolved mechanisms to escape from complement-meditated neutralization and counteracts these immune responses by escaping from lysis, using follicular dendritic cells as anchor to generate a latent viral reservoir and enhancing the infection of antigen-presenting cells. SUMMARY This review will discuss the complex interactions of complement and complement receptors with retroviruses and review the escape mechanisms, which protect this virus family from complement-mediated destruction.