Miracle-dz/UniFAR-FTUs huggingface dataset:
Strengthening the Academic Pipeline Leading to Careers in Math, Science, and Technology for Latino Students

Because Latino students begin school far behind their non-Hispanic peers, moving more of them into the math and science pipeline will require a broad strategy that begins with preliteracy skills. This article reviews existing data on the costs of effective intervention and suggests that we would have to invest from 1.5 to 2 times what we now invest per pupil to provide a seamless web of support to begin to even the playing field for Latino students.
Federal Reserve Bank of New York Staff Reports Commitment and Equilibrium Bank Runs Commitment and Equilibrium Bank Runs

This paper presents preliminary findings and is being distributed to economists and other interested readers solely to stimulate discussion and elicit comments. The views expressed in the paper are those of the authors and are not necessarily reflective of views at the Federal Reserve Bank of New York or the Federal Reserve System. Any errors or omissions are the responsibility of the authors. Abstract We study the role of commitment in a version of the Diamond and Dybvig (JPE, 1983) model with no aggregate uncertainty. As is well known, the banking authority can eliminate the possibility of a bank run by committing to suspend payments to depositors if a run were to start. We show, however, that in an environment without commitment, the banking authority will choose to only partially suspend payments during a run. In some cases, the reduction in early payouts under this partial suspension is insufficient to dissuade depositors from participating in the run. Bank runs can then occur with positive probability in equilibrium. The fraction of depositors participating in such a run is stochastic and can be arbitrarily close to one. Meetings of the Econometric Society, and especially Ed Green for useful comments. The views expressed in this paper are those of the authors and do not necessarily reflect the position of the Federal Reserve Bank of New York, the Federal Reserve Bank of Richmond, or the Federal Reserve System.
Economic Development, Change of Age Distribution, and Stream Analogy of Homicide and Suicide: A Cross-National Assessment

The current study tests the stream analogy of lethal violence, proposed by Unnithan et al. on a large sample of 124 nations. Spatial econometric regression models confirm that economic development decreases homicide rate and increases suicide–homicide ratio (SHR). The SHR developed by Unnithan et al. accounts for the impact of economic development better than original measure of suicide rate. The most important finding of the current investigation is that the increase in the population size of the elderly, consequent to economic development, is partially responsible for elevated suicide rates and SHRs.
Gene expression of behaviorally relevant genes in the cerebral hemisphere changes after selection for tameness in Red Junglefowl

The process of domestication in animals has led to alterations in behavior, physiology and phenotypic traits, changes that may be driven by correlations with reduced fear of humans. We used Red Junglefowl, ancestors of all domesticated chickens selected for either high or low fear of humans for five generations to study the effects of selection on gene transcription in the cerebral hemisphere, which is heavily involved in behaviour control. A total of 24 individuals from the parental generation as well as from the fifth selected generation were used. Twenty-two genes were significantly differentially expressed at p < 0.05 after false discovery rate (FDR) correction. Those genes that were upregulated in the low fearful animals were found to be involved in neural functions. Gene ontology and pathway analysis revealed enrichment for terms associated with behavioural processes. We conclude that five generations of divergent selection for high or low tameness has significantly changed gene expression patterns in the cerebral hemisphere in the Red Junglefowl population used here, which could underlie a range of changes in the domestic phenotype.
Production of Transgenic Pigs Mediated by Pseudotyped Lentivirus and Sperm

Sperm-mediated gene transfer can be a very efficient method to produce transgenic pigs, however, the results from different laboratories had not been widely repeated. Genomic integration of transgene by injection of pseudotyped lentivirus to the perivitelline space has been proved to be a reliable route to generate transgenic animals. To test whether transgene in the lentivirus can be delivered by sperm, we studied incubation of pseudotyped lentiviruses and sperm before insemination. After incubation with pig spermatozoa, 62±3 lentiviral particles were detected per 100 sperm cells using quantitative real-time RT-PCR. The association of lentivirus with sperm was further confirmed by electron microscopy. The sperm incubated with lentiviral particles were artificially inseminated into pigs. Of the 59 piglets born from inseminated 5 sows, 6 piglets (10.17%) carried the transgene based on the PCR identification. Foreign gene and EGFP was successfully detected in ear tissue biopsies from two PCR-positive pigs, revealed via in situ hybridization and immunohistochemistry. Offspring of one PCR-positive boar with normal sows showed PCR-positive. Two PCR-positive founders and offsprings of PCR-positive boar were further identified by Southern-blot analysis, out of which the two founders and two offsprings were positive in Southern blotting, strongly indicating integration of foreign gene into genome. The results indicate that incubation of sperm with pseudotyped lentiviruses can incorporated with sperm-mediated gene transfer to produce transgenic pigs with improved efficiency.
Soluble recombinant coxsackievirus and adenovirus receptor abrogates coxsackievirus b3-mediated pancreatitis and myocarditis in mice.

BACKGROUND Group B coxsackievirus infection can result in organ injury and inflammation. The coxsackievirus and adenovirus receptor (CAR) and decay-accelerating factor (DAF; CD55) have both been identified as receptors for coxsackievirus B3 (CVB3). We have shown elsewhere that early DAF-Fc treatment attenuates CVB3-induced myocarditis and virus replication. METHODS CAR was synthesized as a soluble IgG1-Fc fusion protein (CAR-Fc). In vitro, CAR-Fc blocked infection by 2 different strains of CVB3. A/J mice were infected in vivo with CVB3 and were administered CAR-Fc either 3 days before infection, during infection, or 3 days after infection and were compared with mice infected with virus alone and control animals. RESULTS All CAR-Fc treatment groups had reduced recoverable infectious virus in the heart. CAR-Fc treatment of mice, either preceding or concurrent with CVB3 infection, resulted in complete inhibition of myocardial lesion area, cell death and inflammation, and viral RNA. Early treatment also completely blocked inflammation and cell death in the pancreas, an organ that is normally very sensitive to infection. CONCLUSION To our knowledge, CAR-Fc is the only protein that has been shown to block coxsackievirus infection of the pancreas. However, regardless of the efficacy of the test protein, target tissue cannot be rescued after day 3 of infection in the A/J mouse model.
Risks and benefits of sports and fitness activities for people with haemophilia

Summary. Physical activity is a key component of a healthy lifestyle. Exercise and physical activity have been shown to help maintain a healthy body weight, reduce stress, increase self‐esteem and feelings of wellbeing, control blood pressure, and prevent heart disease and diabetes. Children with haemophilia may feel restricted from competing in sports through parental concern or pain and difficulty in moving, or they may rebel against such restrictions, thus leaving themselves open to serious injury. Several groups have attempted to classify sports activities with regard to the level of risk involved; however, these are not consistent. It is important to match the child's abilities with the sport in which they want to take part, and suggest alternatives if this is not possible. Prevention of injury should not depend solely on use of factor concentrates.
Renyi generalizations of the conditional quantum mutual information

The conditional quantum mutual information $I(A;B|C)$ of a tripartite state $\rho_{ABC}$ is an information quantity which lies at the center of many problems in quantum information theory. Three of its main properties are that it is non-negative for any tripartite state, that it decreases under local operations applied to systems $A$ and $B$, and that it obeys the duality relation $I(A;B|C)=I(A;B|D)$ for a four-party pure state on systems $ABCD$. The conditional mutual information also underlies the squashed entanglement, an entanglement measure that satisfies all of the axioms desired for an entanglement measure. As such, it has been an open question to find R\'enyi generalizations of the conditional mutual information, that would allow for a deeper understanding of the original quantity and find applications beyond the traditional memoryless setting of quantum information theory. The present paper addresses this question, by defining different $\alpha$-R\'enyi generalizations $I_{\alpha}(A;B|C)$ of the conditional mutual information, some of which we can prove converge to the conditional mutual information in the limit $\alpha\rightarrow1$. Furthermore, we prove that many of these generalizations satisfy non-negativity, duality, and monotonicity with respect to local operations on one of the systems $A$ or $B$ (with it being left as an open question to prove that monotoniticity holds with respect to local operations on both systems). The quantities defined here should find applications in quantum information theory and perhaps even in other areas of physics, but we leave this for future work. We also state a conjecture regarding the monotonicity of the R\'enyi conditional mutual informations defined here with respect to the R\'enyi parameter $\alpha$. We prove that this conjecture is true in some special cases and when $\alpha$ is in a neighborhood of one.
Complexity-effective multicore coherence

Much of the complexity and overhead (directory, state bits, invalidations) of a typical directory coherence implementation stems from the effort to make it “invisible” even to the strongest memory consistency model. In this paper, we show that a much simpler, directory-less/broadcast-less, multicore coherence can outperform a directory protocol but without its complexity and overhead. Motivated by recent efforts to simplify coherence, we propose a hardware approach that does not require any application guidance. The cornerstone of our approach is a dynamic, application-transparent, write-policy (write-back for private data, write-through for shared data), simplifying the protocol to just two stable states. Self-invalidation of the shared data at synchronization points allows us to remove the directory (and invalidations) completely, with just a data-race-free guarantee from software. This leads to our main result: a virtually costless coherence that outperforms a MESI directory protocol (by 4.8%) while at the same time reducing shared cache and network energy consumption (by 14.2%) for 15 parallel benchmarks, on 16 cores.
Dynamic analysis and control of dc/dc boost converters used in stand-alone PV systems

A stand-alone photovoltaic (PV) system connected to a resistance load through a dc/dc boost converter is considered. Taking into account the PV source voltage-current nonlinear dependence as well as the dc/dc boost nonlinear dynamic model, an extensive system analysis is conducted. It is proven that as the load power becomes smaller than the maximum power input provided by the PV source, the system acquires the minimum phase property with respect to the output voltage, while the domain of attraction of the stable zero dynamics of the system becomes larger. Exploiting this property, a simple adaptive-based direct output voltage controller is implemented, which acts independently from the system parameters and the equilibrium guaranteeing stability and convergence to the desired operating point. Extensive simulations results verify the theoretical analysis and the system good performance.
Philosophical Issues in Psychiatry II: Nosology

Philosophical Issues in Psychiatry II: Nosology Edited by Kenneth S. Kendler, Josef Parnas. Oxford University Press. 2012. £39.99 (pb). 360pp. ISBN: 9780199642205 This book brings together well-known experts from different professional backgrounds to consider the many conceptual problems that
Targeted nanodiamonds for identification of subcellular protein assemblies in mammalian cells

Transmission electron microscopy (TEM) can be used to successfully determine the structures of proteins. However, such studies are typically done ex situ after extraction of the protein from the cellular environment. Here we describe an application for nanodiamonds as targeted intensity contrast labels in biological TEM, using the nuclear pore complex (NPC) as a model macroassembly. We demonstrate that delivery of antibody-conjugated nanodiamonds to live mammalian cells using maltotriose-conjugated polypropylenimine dendrimers results in efficient localization of nanodiamonds to the intended cellular target. We further identify signatures of nanodiamonds under TEM that allow for unambiguous identification of individual nanodiamonds from a resin-embedded, OsO4-stained environment. This is the first demonstration of nanodiamonds as labels for nanoscale TEM-based identification of subcellular protein assemblies. These results, combined with the unique fluorescence properties and biocompatibility of nanodiamonds, represent an important step toward the use of nanodiamonds as markers for correlated optical/electron bioimaging.
School Uniforms and Discourses on Childhood

This article reports an ethnographic study of the introduction of uniforms in the public schools of one US city. The issue of school uniforms intersects with wide-ranging issues surrounding childhood, including childhood as protected space, safety and violence, egalitarianism, social exclusion, family stress, individual vs community rights, high-powered marketing encouraging students in competitive dressing, and a power struggle over shaping the environment of childhood. Public/official discourse was found to mask problems addressed by the movement for school uniforms. Discussion of uniforms could be put to better use to unearth and explore the larger issues raised by students, parents and teachers themselves, which this article attempts to do.
APRENDIZAGEM ATIVA NO ENSINO SUPERIOR: O CASO DA DISCIPLINA DE SERVIÇO DE REFERÊNCIA E INFORMAÇÃO NA ESCOLA SUPERIOR DE JORNALISMO

A presente pesquisa visa analisar a importância da aprendizagem ativa no ensino superior para o desenvolvimento de competências profissionais dos alunos do curso de Biblioteconomia e Documentação (BD) na disciplina de Serviços de Referência e Informação (SRI) na Escola Superior de Jornalismo (ESJ). Esta pesquisa é de caráter descritivo com uma abordagem qualitativa, baseada em método do caso da disciplina de SRI, que tem como objetivo proporcionar aos alunos o desenvolvimento de competências de comunicação interpessoal, como base teórica e prática dos serviços de referências e informação. Os dados da pesquisa indicam que a importância da aprendizagem ativa no ensino superior é o de proporcionar aos alunos conhecimentos aprofundados da sua área de formação em diferentes perspectivas, desenvolver um espírito pesquisador e de aprendizagem contínua tornando-se assim um questionador com uma visão crítica na sociedade onde encontra-se inserido. Para tal, é necessário assumir uma postura criativa e inovadora face aos desafios de necessidades crescentes de informação impostos pela sociedade, com vista a atuar de forma eficaz no mercado de trabalho informacional.
Batswana female managers' career experiences and perspectives on corporate mobility and success : original research

Orientation: Corporate mobility remains elusive for female managers. Research purpose: To investigate Batswana female managers’ strategies for entering and succeeding in managerial positions, the challenges they face and the consequences of success. Motivation for the study: There is a lack of research into the way Batswana female managers obtain management positions, as well as their experiences as female managers. Research approach, design and method: An interpretive approach using a case study strategy was employed. Semi-structured interviews were conducted which were shaped by the objectives of the study. A sample of female employees ( n = 10), representing different organisations and professions, was obtained from various organisations in Botswana. Main findings: Findings revealed that female managers do experience a number of challenges. Various factors were identified that accounted for their career advancement as well as the consequences of success. The consequences of success were identified as being both positive and negative. Practical/managerial implications: The current study is important as the strategies for success that were identified can be used to assist interested women to obtain management-level positions. Furthermore, the challenges identified may assist both researchers and practitioners to design interventions that help to mitigate the challenges, in turn enabling the inclusion and advancement of women in leadership or managerial positions. Contributions: The current study may contribute new knowledge as past research conducted in Botswana seems to have focused mainly on the impact of regulatory and legislative challenges on women’s advancement. Such a focus ignores the other aspects of female managers’ experiences, which are addressed by the current study.
Medical hypothesis: xenoestrogens as preventable causes of breast cancer.

Changes in documented risk factors for breast cancer and rates of screening cannot completely explain recent increases in incidence or mortality. Established risk factors for breast cancer, including genetics, account for at best 30% of cases. Most of these risk factors can be linked to total lifetime exposure to bioavailable estrogens. Experimental evidence reveals that compounds such as some chlorinated organics, polycyclic aromatic hydrocarbons (PAHs), triazine herbicides, and pharmaceuticals affect estrogen production and metabolism and thus function as xenoestrogens. Many of these xenoestrogenic compounds also experimentally induce mammary carcinogenesis. Recent epidemiologic studies have found that breast fat and serum lipids of women with breast cancer contain significantly elevated levels of some chlorinated organics compared with noncancer controls. As the proportion of inherited breast cancer in the population is small, most breast cancers are due to acquired mutations. Thus, the induction of breast cancer in the majority of cases stems from interactions between host factors, including genetics and environmental carcinogens. We hypothesize that substances such as xenoestrogens increase the risk of breast cancer by mechanisms which include interaction with breast-cancer susceptibility genes. A series of major epidemiologic studies need to be developed to evaluate this hypothesis, including studies of estrogen metabolism, the role of specific xenoestrogenic substances in breast cancer, and relevant genetic-environmental interactions. In addition, experimental studies are needed to evaluate biologic markers of suspect xenoestrogens and biologic markers of host susceptibility and identify pathways of estrogenicity that affect the development of breast cancer. If xenoestrogens do play a role in breast cancer, reductions in exposure will provide an opportunity for primary prevention of this growing disease. (ABSTRACT TRUNCATED AT 250 WORDS) Imagesp372-aFigure 1.
WCST and NEUPSILIN: relationships among executive functions, attention, memory and language

This study investigated the relationship between measures of the Wisconsin Card Sorting Test (WCST) and a brief battery of cognitive functions (NEUPSILIN) with the goal of providing a better understanding of the association between executive processes and other functions. The sample included 39 people, from 14 to 61 years old, with an average education of 12.38 (SD = 3.65) years of study. The hypothesis that correlations would be moderate to strong between the measures of executive function, working memory, attention and prospective memory from NEUPSILIN and WCST scores was partially corroborated because the intensity of the correlations was below than the expected. Other correlations were also found between the WCST scores and tasks that assess semantic-episodic memory, oral language (inference processing) and writing (reading) components.
Effects of Alzheimer Disease on Fronto-parietal Brain N-acetyl Aspartate and Myo-Inositol Using Magnetic Resonance Spectroscopic Imaging

Previous magnetic resonance (MR) spectroscopy studies of Alzheimer disease (AD) reporting reduced N-acetyl aspartate (NAA) and increased myo-Inositol (mI) used single voxel techniques, which have limited ability to assess the regional distribution of the metabolite abnormalities. The objective of this study was to determine the regional distribution of NAA and mI alterations in AD by using MR spectroscopic imaging. Fourteen patients with AD and 22 cognitively normal elderly were studied using structural MR imaging and MR spectroscopic imaging. Changes of NAA, mI, and various metabolite ratios were measured in frontal and parietal lobe gray matter (GM) and white matter. This study found: (1) when compared with cognitively normal subjects, AD patients had increased mI and mI/creatine (Cr) ratios primarily in parietal lobe GM, whereas frontal lobe GM and white matter were spared; (2) in the same region where mI was increased, AD patients had also decreased NAA and NAA/Cr ratios, replicating previous findings; (3) however, increased mI or mI/Cr ratios did not correlate with decreased NAA or NAA/Cr ratios; and (4) using mI/Cr and NAA/Cr together improved sensitivity and specificity to AD from control as compared with NAA/Cr alone. In conclusion, decreased NAA and increased mI in AD are primarily localized in parietal lobe GM regions. However, the NAA and mI changes are not correlated with each other, suggesting that they represent different processes that might help staging of AD.