Miracle-dz/UniFAR-FTUs huggingface dataset:
Organizational overlap on social networks and its applications

Online social networks have become important for networking, communication, sharing, and discovery. A considerable challenge these networks face is the fact that an online social network is partially observed because two individuals might know each other, but may not have established a connection on the site. Therefore, link prediction and recommendations are important tasks for any online social network. In this paper, we address the problem of computing edge affinity between two users on a social network, based on the users belonging to organizations such as companies, schools, and online groups. We present experimental insights from social network data on organizational overlap, a novel mathematical model to compute the probability of connection between two people based on organizational overlap, and experimental validation of this model based on real social network data. We also present novel ways in which the organization overlap model can be applied to link prediction and community detection, which in itself could be useful for recommending entities to follow and generating personalized news feed.
Motor Dysfunctions and Neuropathology in Mouse Models of Spinocerebellar Ataxia Type 2: A Comprehensive Review

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant ataxia caused by an expansion of CAG repeats in the exon 1 of the gene ATXN2, conferring a gain of toxic function that triggers the appearance of the disease phenotype. SCA2 is characterized by several symptoms including progressive gait ataxia and dysarthria, slow saccadic eye movements, sleep disturbances, cognitive impairments, and psychological dysfunctions such as insomnia and depression, among others. The available treatments rely on palliative care, which mitigate some of the major symptoms but ultimately fail to block the disease progression. This persistent lack of effective therapies led to the development of several models in yeast, C. elegans, D. melanogaster, and mice to serve as platforms for testing new therapeutic strategies and to accelerate the research on the complex disease mechanisms. In this work, we review 4 transgenic and 1 knock-in mouse that exhibit a SCA2-related phenotype and discuss their usefulness in addressing different scientific problems. The knock-in mice are extremely faithful to the human disease, with late onset of symptoms and physiological levels of mutant ataxin-2, while the other transgenic possess robust and well-characterized motor impairments and neuropathological features. Furthermore, a new BAC model of SCA2 shows promise to study the recently explored role of non-coding RNAs as a major pathogenic mechanism in this devastating disorder. Focusing on specific aspects of the behavior and neuropathology, as well as technical aspects, we provide a highly practical description and comparison of all the models with the purpose of creating a useful resource for SCA2 researchers worldwide.
Smoking Cessation Research via the Internet: A Feasibility Study

ABSTRACT To reverse the present stagnation in progress toward reduced smoking rates, new widely accessible treatment methods for smoking cessation must be developed and evaluated with large groups of smokers. We tested the feasibility of conducting a smoking cessation study over the Internet using a brief, self-help educational intervention. Through a direct e-mail sent from a large health information web site (WebMD), and with our presence on the Internet, we recruited 538 adult smokers to the study. Most participants (90.5%) completed all baseline questionnaires. Questionnaires showed acceptable to good reliability and were comparable with studies using paper-and-pencil methods. Participants appeared to be highly dependent on nicotine. Forty-two percent indicated being ready to quit smoking at baseline. At 1-month follow-up, 42.8% of baseline participants returned a complete follow-up questionnaire, 40% of whom indicated having made a serious quit attempt, and 8.3% of whom indicated 7-day abstinence. Most follow-up participants rated the site as at least somewhat helpful to quitting (74.9%) and reported at least a slight increased intention to quit smoking over baseline (67.3%). While Internet-enabled self-help interventions for smoking cessation are able to reach large numbers of smokers interested in quitting smoking, additional procedures are needed to retain these users for treatment and follow-up assessments.
Collaborative Summarization: When Collaborative Filtering Meets Document Summarization

We propose a new way of generating personalized single document summary by combining two complementary methods: collaborative filtering for tag recommendation and graph-based affinity propagation. The proposed method, named by Collaborative Summarization, consists of two steps iteratively repeated until convergence. In the first step, the possible tags of one user on a new document are predicted using collaborative filtering which bases on tagging histories of all users. The predicted tags of the new document are supposed to represent both the key idea of the document itself and the special content of interest to that specific user. In the second step, the predicted tags are used to guide graph-based affinity propagation algorithm to generate personalized summarization. The generated summary is in turn used to fine tune the prediction of tags in the first step. The most intriguing advantage of collaborative summarization is that it harvests human intelligence which is in the form of existing tag annotations of webpages, such as delicious.com bookmark tags, to tackle a complex NLP task which is very difficult for artificial intelligence alone. Experiment on summarization of wikipedia documents based on delicious.com bookmark tags shows the potential of this method.
Eccentric and Isometric Hip Adduction Strength in Male Soccer Players With and Without Adductor-Related Groin Pain

Background: Adductor-related pain is the most common clinical finding in soccer players with groin pain and can be a long-standing problem affecting physical function and performance. Hip adductor weakness has been suggested to be associated with this clinical entity, although it has never been investigated. Purpose: To investigate whether isometric and eccentric hip strength are decreased in soccer players with adductor-related groin pain compared with asymptomatic soccer controls. The hypothesis was that players with adductor-related groin pain would have lower isometric and eccentric hip adduction strength than players without adductor-related groin pain. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Male elite and subelite players from 40 teams were contacted. In total, 28 soccer players with adductor-related groin pain and 16 soccer players without adductor-related groin pain (asymptomatic controls) were included in the study. In primary analysis, the dominant legs of 21 soccer players with adductor-related groin pain (≥4 weeks duration) were compared with the dominant legs of 16 asymptomatic controls using a cross-sectional design. The mean age of the symptomatic players was 24.5 ± 2.5 years, and the mean age of the asymptomatic controls was 22.9 ± 2.4 years. Isometric hip strength (adduction, abduction, and flexion) and eccentric hip strength (adduction) were assessed with a handheld dynamometer using reliable test procedures and a blinded assessor. Results: Eccentric hip adduction strength was lower in soccer players with adductor-related groin pain in the dominant leg (n = 21) compared with asymptomatic controls (n = 16), namely 2.47 ± 0.49 versus 3.12 ± 0.43 N·m/kg, respectively (P < .001). No other hip strength differences were observed between symptomatic players and asymptomatic controls for the dominant leg (P = .35-.84). Conclusion: Large eccentric hip adduction strength deficits were found in soccer players with adductor-related groin pain compared with asymptomatic soccer players, while no isometric strength differences were observed between the groups.
Papers in Laboratory Phonology: Tiers in articulatory phonology, with some implications for casual speech

A fluid fitting for attaching fluid conduits to a housing which makes possible a simplified assembly procedure that requires only the insertion of a tube assembly into a preassembled nut located in a threaded opening in the housing. The assembly includes an expandable clip located on the tube between retainer beads formed on the tube. The clip contains locking fingers that engage a shoulder on the nut.
Jumping mechanisms in lacewings (Neuroptera, Chrysopidae and Hemerobiidae)

Lacewings launch themselves into the air by simultaneous propulsive movements of the middle and hind legs as revealed in video images captured at a rate of 1000 s−1. These movements were powered largely by thoracic trochanteral depressor muscles but did not start from a particular preset position of these legs. Ridges on the lateral sides of the meso- and metathorax fluoresced bright blue when illuminated with ultraviolet light, suggesting the presence of the elastic protein resilin. The middle and hind legs were longer than the front legs but their femora and tibiae were narrow tubes of similar diameter. Jumps were of two types. First, those in which the body was oriented almost parallel to the ground (−7±8 deg in green lacewings, 13.7±7 deg in brown lacewings) at take-off and remained stable once animals were airborne. The wings did not move until 5 ms after take-off when flapping flight ensued. Second, were jumps in which the head pointed downwards at take-off (green lacewings, −37±3 deg; brown lacewings, −35±4 deg) and the body rotated in the pitch plane once airborne without the wings opening. The larger green lacewings (mass 9 mg, body length 10.3 mm) took 15 ms and the smaller brown lacewings (3.6 mg and 5.3 mm) 9 ms to accelerate the body to mean take-off velocities of 0.6 and 0.5 m s−1. During their fastest jumps green and brown lacewings experienced accelerations of 5.5 or 6.3g, respectively. They required an energy expenditure of 5.6 or 0.7 μJ, a power output of 0.3 or 0.1 mW and exerted a force of 0.6 or 0.2 mN. The required power was well within the maximum active contractile limit of normal muscle, so that jumping could be produced by direct muscle contractions without a power amplification mechanism or an energy store.
Effects of Hospitalization in a Psychiatric Ward on the Body Weight of Japanese Patients with Schizophrenia

Objective: In Japan, the prevalence of overweight/obesity in the general population is considerably lower and the mean duration of hospitalization of patients with schizophrenia is much longer than those in Europe and North America. The aim of this study was to investigate whether these differences in ethnics or healthcare systems influence the nutritional status of patients with schizophrenia. Methods: Body mass index (BMI) and blood biochemistry tests were determined at hospitalization and at discharge for 171 Japanese patients who were hospitalized for the treatment of acute phase schizophrenia. Results: For 56 patients who were overweight/obese at hospitalization, BMI (p < 0.001), fasting plasma glucose (p = 0.039), and low-density lipoprotein (p = 0.027) were significantly lower at discharge than at hospitalization. BMI at hospitalization, duration of hospitalization, and age were associated with a decrease in BMI during hospitalization. Among the 115 patients who were not overweight/obese at hospitalization, there were no changes in BMI and blood biochemistry tests between hospitalization and discharge. Conclusions: Compared with inpatients, outpatients with schizophrenia may be more likely to be overweight/obese in Japan.
The Relative Importance of T Cell Subsets in Immunity and Immunopathology of Airborne Mycobacterium tuberculosis Infection in Mice

Wild-type (WT) and targeted-mutant mice incapable of making αβ T cells, γδ T cells, class I major histocompatibility complex (MHC), class II MHC, interferon (IFN)-γ, or inducible nitric oxide synthase (NOS2), were infected with Mycobacterium tuberculosis (Mtb) by aerosol, and monitored over time for their ability to (a) control infection, (b) develop histopathology at sites of infection, and (c) survive. WT mice acquired the ability to control and to hold infection at a stationary level from day 20 on. This was associated with the development of a macrophage-dominated alveolitis at sites of infection, with increased synthesis of IFN-γ and NOS2 mRNA, and with an median survival time (MST) of 258.5 d. In the absence of αβ T cells, Mtb grew progressively and rapidly to induce a necrotic, neutrophil-dominated lung pathology that killed mice with an MST of 48 d. In the absence of CD4-mediated immunity (class II−/− mice), progressive bacterial growth continued in the lungs and in other organs beyond day 20, resulting in an MST of 77 d. By contrast, in the absence of CD8 T cell–mediated immunity, lung infection was controlled at a 1 log higher stationary level that induced a similar histopathologic response to that of WT mice, and resulted in an MST of 232 d.
Low Diversity Cryptococcus neoformans Variety grubii Multilocus Sequence Types from Thailand Are Consistent with an Ancestral African Origin

The global burden of HIV-associated cryptococcal meningitis is estimated at nearly one million cases per year, causing up to a third of all AIDS-related deaths. Molecular epidemiology constitutes the main methodology for understanding the factors underpinning the emergence of this understudied, yet increasingly important, group of pathogenic fungi. Cryptococcus species are notable in the degree that virulence differs amongst lineages, and highly-virulent emerging lineages are changing patterns of human disease both temporally and spatially. Cryptococcus neoformans variety grubii (Cng, serotype A) constitutes the most ubiquitous cause of cryptococcal meningitis worldwide, however patterns of molecular diversity are understudied across some regions experiencing significant burdens of disease. We compared 183 clinical and environmental isolates of Cng from one such region, Thailand, Southeast Asia, against a global MLST database of 77 Cng isolates. Population genetic analyses showed that Thailand isolates from 11 provinces were highly homogenous, consisting of the same genetic background (globally known as VNI) and exhibiting only ten nearly identical sequence types (STs), with three (STs 44, 45 and 46) dominating our sample. This population contains significantly less diversity when compared against the global population of Cng, specifically Africa. Genetic diversity in Cng was significantly subdivided at the continental level with nearly half (47%) of the global STs unique to a genetically diverse and recombining population in Botswana. These patterns of diversity, when combined with evidence from haplotypic networks and coalescent analyses of global populations, are highly suggestive of an expansion of the Cng VNI clade out of Africa, leading to a limited number of genotypes founding the Asian populations. Divergence time testing estimates the time to the most common ancestor between the African and Asian populations to be 6,920 years ago (95% HPD 122.96 - 27,177.76). Further high-density sampling of global Cng STs is now necessary to resolve the temporal sequence underlying the global emergence of this human pathogen.
Modulation of hepatic CYP2A1, CYP2C11, and CYP3A9 expression in adult rats by neonatal administration of tamoxifen.

To examine the effect of neonatal administration of tamoxifen on adult expression of hepatic cytochrome P-450 (CYP) enzymes and steroid 5alpha-reductase, male and female Sprague-Dawley rats were injected s.c. with tamoxifen (20 microg) or peanut oil (control) once daily at days 1 to 5 of age and sacrificed at 3 months of age. Neonatal tamoxifen treatment did not affect b.wt. or liver weight of adult male and female rats, but decreased testicular weight by approximately 40% in adult male rats. Neonatal administration of tamoxifen decreased hepatic microsomal testosterone 6beta- and 7alpha-hydroxylase activities in adult female rats whereas it did not alter steroid 5alpha-reductase activity. The same treatment increased testosterone 7alpha-hydroxylase activity, but did not affect testosterone 6beta-hydroxylase or steroid 5alpha-reductase activity in adult male rats. Immunoblot analysis indicated that neonatal tamoxifen treatment decreased CYP2C11 protein level by 26% and increased CYP2A1 protein content by 2.6-fold in adult male rats, whereas it had no effect on CYP3A or CYP2B protein expression. The reduction in the CYP3A-mediated testosterone 6beta-hydroxylase activity in adult female rats was accompanied by a decrease in CYP3A9 mRNA expression. Analysis of serum hormone levels indicated that neonatal exposure to tamoxifen resulted in a decrease in serum 17beta-estradiol concentration in adult female rats, whereas it did not alter serum testosterone concentration in adult male rats. In summary, treatment of neonatal rats with tamoxifen produced a long-lasting effect on hepatic CYP2A1, CYP2C11, and CYP3A9 expression in addition to testicular weight and serum 17beta-estradiol concentration.
Cyber-Physical Security: A Game Theory Model of Humans Interacting Over Control Systems

Recent years have seen increased interest in the design and deployment of smart grid devices and control algorithms. Each of these smart communicating devices represents a potential access point for an intruder spurring research into intruder prevention and detection. However, no security measures are complete, and intruding attackers will compromise smart grid devices leading to the attacker and the system operator interacting via the grid and its control systems. The outcome of these machine-mediated human-human interactions will depend on the design of the physical and control systems mediating the interactions. If these outcomes can be predicted via simulation, they can be used as a tool for designing attack-resilient grids and control systems. However, accurate predictions require good models of not just the physical and control systems, but also of the human decision making. In this manuscript, we present an approach to develop such tools, i.e., models of the decisions of the cyber-physical intruder who is attacking the systems and the system operator who is defending it, and demonstrate its usefulness for design.
Gene-Expression Profiles and Breast-Cancer Prognosis

High throughput measurements of gene expression make it possible to simultaneously survey tens of thousands of markers to obtain a “snapshot” of a cancer genome at a given point in time. This study by van de Vijver et al describes a 70-gene “prognosis classifier set” that stratified a 295-patient cohort with regionally localized breast cancer into good and poor prognostic groups. This commentary discusses how the classifier array was created, what its most promising use may be, limitations of the data presented and how prognostic factor study design principles must be adapted to this new and important technology.
Some first-order observations on magma transfer from mantle wedge to upper crust at volcanic arcs

Abstract The viscosity of lavas erupted at volcanic arcs varies over orders of magnitude. A comparison of the relative abundance of viscous lava dome eruptions indicates that the average viscosity of arc lavas also varies considerably between arcs. It is shown that, for continental or transitional arcs with little within-arc crustal deformation and without underlying slab windows or tears, average lava viscosity is anticorrelated with average surface heat flux. The latter may be influenced by crustal thickness and crustal magma throughput. To constrain the relative contributions of these parameters, variations of average lava viscosity with average crustal thickness and plate convergence rate are assessed. While crustal thickness appears to have little effect on average lava viscosity, a good anticorrelation exists between average lava viscosity and plate convergence rate, with the exception of two arcs that show significant intra-arc crustal deformation. If plate convergence rate is a good proxy of the rate of melt generation within the mantle wedge, these first-order observations indicate that, where the rate of mantle melting is high, crustal magma throughput is rapid and efficient, resulting in low-viscosity melts migrating through a hot overriding crust; in contrast, where the rate of mantle melting is low, crustal magma transfer is slow and inefficient, resulting in high-viscosity melts that may frequently stall within a cool overriding crust prior to eruption. Uranium series geochemical evidence from dome lavas is presented and lends support to this interpretation. Finally, some explanations are offered for the observed average viscosity variations of arcs with underlying slab windows or tears and/or significant intra-arc crustal deformation.
Task-constrained continuum manipulation in cluttered space

Continuum manipulators do not contain rigid links and can deform continuously to perform a whole arm manipulation. Hence, they are much more flexible than articulated manipulators to perform tasks in cluttered space. However, autonomous manipulation constrained by tasks other than grasping has not been studied for continuum manipulators. In this paper, we introduce a general and efficient approach for autonomous continuum manipulation under task constraints. We consider a spatial continuum manipulator with multiple uniform-curvature sections if not deformed. We further apply the approach to an example of inspection task in a cluttered environment to verify its effectiveness. The high-efficiency of our approach makes it suitable to run on-line for guiding task-constrained manipulation in real-time.
Internet Engineering Task Force (ietf) Name Attributes for the Gss-api Extensible Authentication Protocol (eap) Mechanism

The naming extensions to the Generic Security Service Application Programming Interface (GSS-API) provide a mechanism for applications to discover authorization and personalization information associated with GSS-API names. The Extensible Authentication Protocol GSS-API mechanism allows an Authentication, Authorization, and Accounting (AAA) peer to provide authorization attributes alongside an authentication response. It also supplies mechanisms to process Security Assertion Markup Language (SAML) messages provided in the AAA response. This document describes how to use the Naming Extensions API to access that information.
Connectivity preserving distributed swarm aggregation for multiple kinematic agents

A distributed swarm aggregation algorithm is developed for a team of multiple kinematic agents. Each agent is assigned with a control law which is the sum of two elements: a repulsive potential field, which is responsible for the collision avoidance objective, and an attractive potential field, that drives the agents to a configuration where they are close to each other and forces the agents that are initially located within the sensing radius of an agent to remain within this area for all time. In this way, the connectivity properties of the initially formed communication graph are rendered invariant for the trajectories of the closed loop system. It is shown that agents converge to a configuration where each agent is located at a bounded distance from each of its neighbors. The results are also extended to the case of nonholonomic kinematic agents and to the dynamic edge addition case, for which we derive a better bound in the swarm size than in the static case.