Miracle-dz/UniFAR-FTUs huggingface dataset:
Precursor B-Cell Acute Lymphoblastic Leukemia/Lymphoma with L3 Morphology, Philadelphia Chromosome, MYC Gene Translocation, and Coexpression of TdT and Surface Light Chains: A Case Report

Acute lymphoblastic leukemia is predominantly found in children. It is a neoplasm of precursor cells or lymphoblasts committed to either a B- or T-cell lineage. The immature cells in B-acute lymphoblastic leukemia/lymphoma can be small or medium sized with scant or moderate cytoplasm and typically express B-cell markers such as CD19, cytoplasmic CD79a, and TdT without surface light chains. These markers, along with cytogenetic studies, are vital to the diagnosis, classification, and treatment of these neoplasms. We present an unusual case of a precursor B-cell ALL, in an 82-year-old woman, who presented with pancytopenia and widespread lymphadenopathy. The cells show L3 morphology (Burkitt-like lymphoma) with coexpression of TdT and surface light chains in addition to an MYC gene translocation and Philadelphia chromosome.
Via Minimization for Gridless Layouts

This paper describes a graph theoretic algorithm which, given a particular layout, finds a layer assignment that requires the minimum number of vias. The time complexity of the algorithm is O(n /sup 3/) where n is the number of routing segments in the given layout. Unlike previous algorithms, this algorithm does not require the layout to be grid based and places no constraints on the location of vias or the number of wires that may be joined at a single junction. The algorithm yields globally optimum results when the maximum junction degree is limited to three and has been fully implemented.
Molecular diagnostic methods for Mycobacterium avium subsp. paratuberculosis

Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of the chronic enteric disease paratuberculosis in ruminants that causes considerable economic losses worldwide. Due to rigorous control measures, paratuberculosis is rare or absent in Sweden. However, import-related outbreaks have occurred. Diagnostic surveillance and outbreak investigations are mainly carried out by very slow culture methods. Faster and equally reliable molecular methods are needed for detection of MAP in several clinical matrixes. MAP is primarily shed in faeces, the most important testing material. The abundance of PCR inhibitory substances in faeces constitutes a diagnostic challenge. Semen, imported for breeding purposes, may contain MAP if the donor bulls are asymptomatic carriers. MAP has been suggested as the causative agent of Crohn's disease and its presence in consumers' milk might be of concern. In this thesis, the development and sensitivity assessment of protocols for detection of MAP in ruminant faeces, semen and milk by real-time PCR are described. The analytical sensitivities were assessed to 104 MAP/g faeces, 10 MAP/100 µl semen and 100 MAP/ml milk. The faeces direct PCR was validated on 202 proficiency test samples. MAP was detected in 97% of previously frozen positive samples - better than culture. Pellet and cream fractions of milk were pooled before cell lysis and DNA extraction by automated magnetic bead separation. In a study of 56 dairy herds, tank milk PCR was compared to culture of environmental faecal samples for herd prevalence testing. By the latter, 68% of the herds were positive, while 30% were positive by PCR. Due to the concluded low abundance of MAP in milk tanks, milk PCR would be more useful for testing of MAP in consumers’ milk, than for herd prevalence testing. Three real-time PCR systems were designed for confirmation of PCR positives and validated on 267 strains and 58 positive faecal and tissue samples. The system based on the gene F57 was the most specific. A faecal culture screening of 501 wild guanacos in Chile yielded MAP colonies from 21 guanacos (4.2%), representing the first isolation of MAP from wild animals in the Chilean Patagonia. Confirmation was done by PCR and typing was performed by PCR-REA. All strains proved to be of C type.
Through a Gender Lens: A View of Gender and Leadership Positions in a Department of Medicine.

BACKGROUND Despite increasing numbers in academic medicine, women remain underrepresented in top leadership positions. The objectives of this study were to characterize leadership positions held by department of medicine (DOM) faculty at all ranks at one Academic Health Center and to compare leadership positions held by male and female faculty. METHODS This was a cross-sectional survey to collect information on all leadership positions from 16 divisions in the DOM at the Johns Hopkins University School of Medicine in early 2012, including type of position, method used to fill the position, and financial compensation. Chi-square testing was used to compare leadership position characteristics by rank and gender. RESULTS The study included 474 DOM faculty at the rank of instructor or higher; 38% were women. Of the 258 leadership positions identified, 35% were held by women. More leadership positions among assistant professors were held by women compared with men (56% of positions vs. 44%), with women assistant professors more likely to hold a leadership position than men (p=0.03). Numbers of women faculty declined at higher ranks, with leadership positions remaining proportionate to faculty representation. Most division director positions (88%) were held by men, and most leadership positions were compensated (89%) and appointed by the DOM chair or a division director (80%). CONCLUSIONS Leadership positions held by women and men were proportionate to faculty representation, although the top leadership positions were held almost exclusively by men. While female assistant professors were more likely to hold leadership positions than male assistant professors, these positions appear to be low status positions and it is not clear that they contribute to professional advancement, as few women hold the rank of full professor. Effective interventions are needed to address the gender disparity in top leadership positions.
Rosmarinic acid content in basil plants grown in vitro and in hydroponics

The accumulation of selected caffeic acid derivatives (CADs), in particular rosmarinic acid (RA), was investigated in different tissues (leaves, roots and plantlet shoots) of sweet basil (Ocimum basilicum L.) plants grown either in vitro or in hydroponic culture (floating system) under greenhouse conditions. Two cultivars with green leaves (Genovese and Superbo) and one with purple leaves (Dark Opal) were tested. The content of CADs in HCl-methanol extracts was determined by HPLC. LC-MS and LC-MS-MS were used to confirm the identification of the metabolites of interest. Apart from rosmarinic acid (RA) and a methylated form of this substance, no other CADs were detected at significant level in any of the analyzed samples. The content of RA ranged approximately from 4 to 63 mg/g DW, depending on the growing system. The highest RA content was found during the in vitro multiplication, in the acclimatized plants and in the roots of hydroponically-grown seedlings at full bloom. In vitro, 6-benzyladenine reduced the accumulation of RA in purple-leaf Dark Opal cultivar, but an opposite effect of this growth regulator was observed in the green-leaf genotypes. Our findings suggest the possibility to scale-up RA production by means of in vitro or hydroponic culture of sweet basil.
Radio Resource Allocation Algorithms for the Downlink of Multiuser OFDM Communication Systems

This article surveys different resource allocation algorithms developed for the downlink of multiuser OFDM wireless communication systems. Dynamic resource allocation algorithms are categorized into two major classes: margin adaptive (MA) and rate adaptive (RA). The objective of the first class is to minimize the total transmit power with the constraint on users' data rates whereas in the second class, the objective is to maximize the total throughput with the constraints on the total transmit power as well as users' data rates. The overall performance of the algorithms are evaluated in terms of spectral efficiency and fairness. Considering the trade-off between these two features of the system, some algorithms attempt to reach the highest possible spectral efficiency while maintaining acceptable fairness in the system. Furthermore, a large number of RA algorithms considers rate proportionality among the users and hence, are categorized as RA with constrained-fairness. Following the problem formulation in each category, the discussed algorithms are described along with their simplifying assumptions that attempt to keep the performance close to optimum but significantly reduce the complexity of the problem. It is noted that no matter which optimization method is used, in both classes, the overall performance is improved with the increase in the number of users, due to multiuser diversity. Some on-going research areas are briefly discussed throughout the article.
The ITS2 Database III—sequences and structures for phylogeny

The internal transcribed spacer 2 (ITS2) is a widely used phylogenetic marker. In the past, it has mainly been used for species level classifications. Nowadays, a wider applicability becomes apparent. Here, the conserved structure of the RNA molecule plays a vital role. We have developed the ITS2 Database (http://its2.bioapps.biozentrum.uni-wuerzburg.de) which holds information about sequence, structure and taxonomic classification of all ITS2 in GenBank. In the new version, we use Hidden Markov models (HMMs) for the identification and delineation of the ITS2 resulting in a major redesign of the annotation pipeline. This allowed the identification of more than 160 000 correct full length and more than 50 000 partial structures. In the web interface, these can now be searched with a modified BLAST considering both sequence and structure, enabling rapid taxon sampling. Novel sequences can be annotated using the HMM based approach and modelled according to multiple template structures. Sequences can be searched for known and newly identified motifs. Together, the database and the web server build an exhaustive resource for ITS2 based phylogenetic analyses.
Omniview-based concurrent map building and localization using adaptive appearance maps

This paper describes a novel omnivision-based concurrent map-building and localization (CML) approach which is able to robustly localize a mobile robot in a uniformly structured, maze-like environment with changing appearances. The presented approach extends and improves known appearance-based CML techniques in a few essential aspects. For example, an advanced learning scheme in combination with an active forgetting is introduced to allow a complexity restricting adaptation of the environment model to appearance variations of the operation area. Moreover, a generalized scheme for fusion of localization hypotheses from several state estimators with different meaning and certainty and a distributed coding of the current observation by a weighted set of reference observations is proposed. Finally, several real-world localization experiments investigating the stability and localization accuracy of this novel omnivision-based CML technique for a highly dynamic and populated operation area, a home store, are presented.
A national profile of health care utilization and expenditures for children with special health care needs.

OBJECTIVES To provide the first nationally representative data on total health care expenses, out-of-pocket health care expenses, and information on the extent to which out-of-pocket expenses are financially burdensome for families of children with special health care needs (CSHCN). To also compare utilization and expenditure patterns for children with and without special health care needs. DESIGN We used data from the 2000 Medical Expenditure Panel Survey (MEPS). We present univariate, bivariate, and multivariate statistics on utilization and expenditures adjusted for the complex sample design. PARTICIPANTS The 2000 MEPS data set contains 6965 children younger than 18 years. Using the CSHCN definition adopted by the federal Maternal and Child Health Bureau and operationalized using the CSHCN Screener, 949 children (15.6%) were identified as children with special health care needs. MAIN OUTCOME MEASURES Compared with other children, CSHCN had 3 times higher health care expenditures (2099 dollars vs 628 dollars; P<.01). The 15.6% of CSHCN accounted for 42.1% of total medical care costs (excluding dental costs) and 33.6% of total health care costs (including dental costs) attributed to children in 2000. Families of CSHCN were best protected against inpatient hospital care expenses and most exposed to dental care expenses. Families of CSHCN experiencing high out-of-pocket expenses (exceeding 5% of family income) were approximately 11 times more likely to be from households with incomes below 200% of the federal poverty level (odds ratio, 10.9; 95% confidence interval, 3.55-33.76) than to be from families with incomes at or above 400% of the federal poverty level. CONCLUSIONS Families with CSHCN experience much higher expenditures, including out-of-pocket expenditures, than other children. Insurance plays an important protective role for families of CSHCN, but it still provides incomplete protection. Health policy changes that would extend the breadth and depth of insurance coverage are needed to ensure that all families of CSHCN are protected against burdensome expenses.
Barbara A. Fox, The Human Tutorial Dialogue Project: Issues in the design of instructional systems . Hillsdale, NJ: Erlbaum, 1993. Pp. xiii, 130. Hb $32.50.

(62). He describes it as highly syncretic and as reflecting a range of sources, from popular psychology to Eastern mysticism and spiritualism, which are clearly beyond a Christian tradition. For scholars interested in religious language, this is a fascinating observation which deserves much more attention (although clearly beyond the intended focus of the present book). By creatively integrating contemporary insights on the nature of language, psychological theory, and the methods of discourse analysis, this volume offers a detailed, thought-provoking and convincing account of the role of narratives and their performance in the process of personal transformation through religious conversion. In the final chapter the implications of the work are extended, most appropriately, to other fields of discourse such as psychotherapy and counseling, whose primary function is to affect a transformation of the self. Thus, while the book is essential reading for those interested in issues of language and religion, and in the processes of religious conversion and commitment, Stromberg's work makes a significant contribution to more general issues concerning the relation among language, culture, and the individual.
Lifetime prevalence and co-morbidity of externalizing disorders and depression in prospective assessment

Background Epidemiological research is believed to underestimate the lifetime prevalence of mental illness due to recall failure and a lack of rapport between researchers and participants. Method In this prospective study, we examined lifetime prevalence and co-morbidity rates of substance use disorders, antisocial personality disorder (ASPD) and major depressive disorder (MDD) in a representative, statewide Minnesota sample (n = 1252) assessed four times between the ages of 17 and 29 years with very low attrition. Results Lifetime prevalence rates of all disorders more than doubled between the ages of 17 and 29 years in both men and women, and our prospective rates at the age of 29 years were consistently higher than rates from leading epidemiological surveys. Although there was some variation, the general trend was for lifetime co-morbidity to increase between the ages of 17 and 29 years, and this trend was significant for MDD–alcohol dependence, MDD–nicotine dependence, and ASPD–nicotine dependence. Conclusions Overall, our results show that emerging adulthood is a high-risk period for the development of mental illness, with increases in the lifetime prevalence and co-morbidity of mental disorders during this time. More than a quarter of individuals had met criteria for MDD and over a fifth had experienced alcohol dependence by the age of 29 years, indicating that mental illness is more common than is estimated in cross-sectional mental health surveys. These findings have important implications for the measurement of economic burden, resource allocation toward mental health services and research, advocacy organizations for the mentally ill, and etiological theories of mental disorders.
Decline in HIV Prevalence among Young Men in the General Population of Cotonou, Benin, 1998–2008

Objective To assess changes in the prevalence of HIV and other sexually transmitted infections, as well as in different proximal and distal factors related to HIV infection, in the general population of Cotonou between 1998 and 2008, while an intensive preventive intervention targeting the sex work milieu was ongoing. Methods A two-stage cluster sampling procedure was used to select the participants in each study. Subjects aged 15–49 who agreed to participate were interviewed and tested for HIV, syphilis, HSV-2, gonorrhoea and chlamydia. We used the Roa-Scott Chi-square test (proportions) and the Student’s t test (means) for bivariate comparisons, and adjusted logistic regression models taking into account the cluster effect for multivariate analyses. Results HIV prevalence decreased significantly in men (3.4% in 1998 versus 2.0% in 2008, p = 0.048), especially in those aged 15–29 (3.0% to 0.5%, p = 0.002). Among men, the prevalence of gonorrhoea decreased significantly (1.1% to 0.3%, p = 0.046) while HSV-2 prevalence increased from 12.0% to 18.1% (p = 0.0003). The proportion of men who reported condom use at least once (29.3% to 61.0%, p<0.0001) and of those having attained a secondary educational level or more (17.1% to 61.3%, p<0.0001) also increased significantly. There was an overall decrease in the prevalence of syphilis (1.5% to 0.6%, p = 0.0003). Conclusion This is the first population-based study reporting a significant decline in HIV prevalence among young men in an African setting where overall prevalence has never reached 5%. The decline occurred while preventive interventions targeting the sex work milieu were ongoing and the educational level was increasing.
Fluoxetine monotherapy of bipolar type II and bipolar NOS major depression: a double-blind, placebo-substitution, continuation study

Current guidelines for the treatment of bipolar type II (BP II) major depressive episode (MDE) recommend using either mood stabilizer monotherapy or the combination of a mood stabilizer with a selective serotonin reuptake inhibitor (SSRI). These guidelines are the result of concern over SSRI-induced manic switch episodes. We previously showed that fluoxetine monotherapy may be effective as an initial treatment for BP II and BP NOS MDE with a low manic switch rate. We now present the results of a double-blind, placebo-substitution continuation study of fluoxetine monotherapy in BP II and BP NOS patients who have recovered from their MDE. This was a two-phase study. In study phase I, patients received open-label fluoxetine monotherapy 20 mg daily for up to 8 weeks. Responders with a final 17-item Hamilton Rating Scale for Depression (HAM-D) score≤9 were enrolled into study phase II which consisted of double-blind, placebo-substitution continuation therapy with fluoxetine 20 mg daily for up to 6 months. Outcome measures included the 17-item HAM-D and Young Mania Rating (YMR) scales. Changes in YMR scores were assessed using generalized estimating equation analysis. Relapse was assessed using Kaplan–Meier survival analysis and Fisher's exact test. In study phase II, 43% of fluoxetine-treated patients and 100% of placebo-treated patients relapsed during continuation therapy (P=0.08). The mean increase in YMR score in study phase II was slightly higher in the fluoxetine-treated patients (3.0±1.8) versus placebo-treated patients (0.2±0.4) (P=0.01). However, this difference was not clinically meaningful. No hypomanic switch episodes were observed during study phase II. Despite the limited sample size resulting in insufficient power to detect statistical significance in relapse rates or change in YMR scores between treatment conditions, these preliminary data appear to support previous observations demonstrating that initial and continuation fluoxetine monotherapy may be safe and effective for some patients with BP II or BP NOS MDE with a low manic switch rate. Larger-scale studies are needed to confirm these findings.
Guardians of the State’s Problem Children

Cottage staff members in a juvenile training school play a crucial role in the state’s attempts to rehabilitate or resocialize adolescent offenders. As the predominant adult influences in the lives of juvenile inmates during their incarceration, cottage staff members set the tone and help to define the institutional experience for the youth assigned to the living unit. In this ethnographic study of one cottage of violent offenders, the author examines and discusses the crucial role of cottage staff members who, in many ways, embody the spirit of parens patriae and serve as their adolescent inmates’ guardians, keepers, counselors, and role models.
Effects of training and instruction on analytic and belief-based reasoning processes

Two studies are reported which demonstrate that analytic responding on everyday reasoning problems can be increased and bias eliminated after training on the law of large numbers (Fong, Krantz, & Nisbett, 1986). Critical thinking problems involving belief-consistent, neutral, and inconsistent conclusions were presented. Belief bias was eliminated when a written justification of argument strength was elicited. However, belief-based responding was still evident when evaluations of the arguments were elicited using rating scales. This finding demonstrates a dissociation between analytic and belief-based responding as a function of response format. In Experiment 2 an instructional condition designed to foster decontextualised reasoning was included but was ineffective in reducing the degree to which judgements were biased by beliefs. It was concluded that training which makes available the analytic strategies necessary to evaluate a problem has the potential to facilitate performance only if the requested response triggers conscious deliberation of the evidence.
Rhythm and stress intervals in Greek and Russian

This paper presents the results of a pilot study of stress interval durations in Greek and Russian. Native speakers of each language were recorded producing utterances in which the number of syllables between stressed syllables varied. The results showed a noticeable tendency towards isochrony in Greek but not in Russian, according to which there is an inverse relation between the number of syllables and syllabic durations in produced utterances. Second, lexical stress has a lengthening effect in Greek but hardly in Russian, while focus has no effect in either language.
The Effects of Hot Spots Policing on Crime

In recent years, researchers have argued that police actions should be focused on high-risk crime places rather than spread thinly across the urban landscape. This review examines the available evaluation evidence on the effects of concentrating police enforcement efforts on crime hot spots. Five randomized experiments and four nonequivalent control group quasi-experiments were identified. The findings of these evaluations suggest that focused police actions can prevent crime and disorder in crime hot spots. These studies also suggest that focused police actions at specific locations do not necessarily result in crime displacement. Unintended crime prevention benefits were also associated with the hot spots policing programs. Although these evaluations reveal that these programs work in preventing crime, additional research is needed to unravel other important policy-relevant issues such as community reaction to focused police enforcement efforts.