Miracle-dz/UniFAR-FTUs huggingface dataset:
Design and Implementation of Low Power LUT Based on Nonvolatile RRAM

Emerging nonvolatile memories (NVMs), such as MRAM, prom, and RRAM, as well as a wide array of field-programmable gate for greater security and immediate energy arrays (FPGAs) have been investigated in place of SRAM configuration bits. However, NVMs and variations inherent in the process of modern logic, FPGAs bring to a matter of credibility. This is neither a matter of credibility, tolerating diversity to overcome a low-power nonvolatile lookup table (nvLUT) circuit contact. Because of the large ROFF / RON, 1T1R RRAM cell configuration bit and a reference resistor provides a sufficient margin of sense. The clamp voltage without impairing the reliability of a single-stage sense amplifier is employed to reduce power and area. Matched the forecast path for reliable sensing the parasitic RC proposed to reduce the imbalance. A reduction of 22% to 38% reduction in the delay in the evaluation of the power, and reliability of the 2.5 × typical RON or ROFF tolerance
Effective Basic Skills Instruction: The Case for Contextualized Developmental Math. Policy Brief 11-1.

Dr. W. Charles Wiseley has worked in the California Community College system since 1982. His research and accountability work examines student outcomes and factors involved in student success. He has authored and coauthored numerous reports and articles on the impact of community college education on students such as Post College Earnings of Former Students of California Community Colleges, Credentials Count: How California’s Community Colleges Help Parents Move from Welfare to Self-sufficiency, and From Jobs to Careers. Entering the second decade of the 21st century, California faces unprecedented demographic, economic, political, and social changes. As the state emerges from another recession, jobs that remain and those opening require workers with higher-order skills most often acquired in postsecondary education. Increasing numbers of adults look to community colleges to learn those skills and to find a way out of a cycle of low paying, unstable jobs. Even workers with years of experience see community colleges as a mechanism to keep their jobs by increasing their skill levels and their appeal to employers.
Dietary Selenium Levels Affect Selenoprotein Expression and Support the Interferon-γ and IL-6 Immune Response Pathways in Mice

Selenium is an essential element that is required to support a number of cellular functions and biochemical pathways. The objective of this study was to examine the effects of reduced dietary selenium levels on gene expression to assess changes in expression of non-selenoprotein genes that may contribute to the physiological consequences of selenium deficiency. Mice were fed diets that were either deficient in selenium or supplemented with selenium in the form of sodium selenite for six weeks. Differences in liver mRNA expression and translation were measured using a combination of ribosome profiling, RNA-Seq, microarrays, and qPCR. Expression levels and translation of mRNAs encoding stress-related selenoproteins were shown to be up-regulated by increased selenium status, as were genes involved in inflammation and response to interferon-γ. Changes in serum cytokine levels were measured which confirmed that interferon-γ, as well as IL-6, were increased in selenium adequate mice. Finally, microarray and qPCR analysis of lung tissue demonstrated that the selenium effects on immune function are not limited to liver. These data are consistent with previous reports indicating that adequate selenium levels can support beneficial immune responses, and further identify the IL-6 and interferon-γ pathways as being responsive to dietary selenium intake.
The impact of diagnostic testing on therapeutic interventions.

OBJECTIVE To gain insight into the usefulness of managing the earlier phase of decision making, we examined the relationship between selected diagnostic tests and the therapeutic interventions they might trigger. DESIGN Medicare's National Claims History and Part B files were used to obtain summary information on 100% of all physician claims submitted from 1987 through 1993. We regressed the annual rates of selected therapeutic interventions on selected diagnostic tests, which had been previously paired based on the clinical expectation that the test might drive subsequent intervention. POPULATION AND SETTING These data represent the physician services received by approximately 30 million elderly Americans in each of 7 years. MAIN OUTCOME MEASURE Coefficient of determination (R2). RESULTS The annual rate for the diagnostic tests increased rapidly during the period (range, 1.4- to 3.0-fold increase) and accounted for the bulk of the variance in therapeutic intervention rates (R2>0.80, P<.01) for five diagnostic-therapeutic pairs: cardiac catheterization with cardiac revascularization procedures, imaging of the spine with back surgery, swallowing studies with percutaneous gastrostomy, mammography with breast biopsy and excision, and prostate biopsy with prostatectomy. Although the rate of abdominal ultrasound increased during the period, it was not related with either cholecystectomy or abdominal aortic aneurysm repair. CONCLUSION There has been a substantial increase in diagnostic testing in the United States that closely tracked the increase of clinically relevant downstream procedures. Managing diagnostic testing could be an important strategy for controlling the increase of therapeutic interventions.
Steady-state and dynamic properties of cardiac sodium-calcium exchange. Sodium-dependent inactivation

Sodium-calcium exchange current was isolated in inside-out patches excised from guinea pig ventricular cells using the giant patch method. The outward exchange current decayed exponentially upon activation by cytoplasmic sodium (sodium-dependent inactivation). The kinetics and mechanism of the inactivation were studied. (a) The rate of inactivation and the peak current amplitude were both strongly temperature dependent (Q10 = 2.2). (b) An increase in cytoplasmic pH from 6.8 to 7.8 attenuated the current decay and shifted the apparent dissociation constant (Kd) of cytoplasmic calcium for secondary activation of the exchange current from 9.6 microM to < 0.3 microM. (c) The amplitude of exchange current decreased synchronously over the membrane potential range from -120 to 60 mV during the inactivation, indicating that voltage dependence of the exchanger did not change during the inactivation process. The voltage dependence of exchange current also did not change during secondary modulation by cytoplasmic calcium and activation by chymotrypsin. (d) In the presence of 150 mM extracellular sodium and 2 mM extracellular calcium, outward exchange current decayed similarly upon application of cytoplasmic sodium. Upon removal of cytoplasmic sodium in the presence of 2-5 microM cytoplasmic free calcium, the inward exchange current developed in two phases, a fast phase within the time course of solution changes, and a slow phase (tau approximately 4 s) indicative of recovery from sodium-dependent inactivation. (e) Under zero-trans conditions, the inward current was fully activated within solution switch times upon application of cytoplasmic calcium and did not decay. (f) The slow recovery phase of inward current upon removal of cytoplasmic sodium was also present under the zero-trans condition. (g) Sodium-dependent inactivation shows little or no dependence on membrane potential in guinea pig myocyte sarcolemma. (h) Sodium-dependent inactivation of outward current is attenuated in rate and extent as extracellular calcium is decreased. (i) Kinetics of the sodium-dependent inactivation and its dependence on major experimental variables are well described by a simple two-state inactivation model assuming one fully active and one fully inactive exchanger state, whereby the transition to the inactive state takes place from a fully sodium-loaded exchanger conformation with cytoplasmic orientation of binding sites (E1.3Ni).
Pilus hijacking by a bacterial coaggregation factor critical for oral biofilm development

Significance The development of dental plaque biofilm requires specific and sequential molecular interactions between oral bacteria-colonizing host surfaces. Coaggregation between early colonizers is crucial to establish an environment suitable for late colonizers. Here, we describe that a surface protein in a Gram-positive bacterium that is not genetically linked to the fimbrial gene clusters hijacks a specific fimbrial polymerization apparatus to be displayed on the fimbrial tip. This tip-localized protein not only functions as the bona fide cell-to-cell adhesion factor for mediating coaggregation between the early colonizers Actinomyces oris and Streptococcus oralis but also serves as an initiator of fimbrial assembly. The formation of dental plaque, a highly complex biofilm that causes gingivitis and periodontitis, requires specific adherence among many oral microbes, including the coaggregation of Actinomyces oris with Streptococcus oralis that helps to seed biofilm development. Here, we report the discovery of a key coaggregation factor for this process. This protein, which we named coaggregation factor A (CafA), is one of 14 cell surface proteins with the LPXTG motif predicted in A. oris MG1, whose function was hitherto unknown. By systematic mutagenesis of each of these genes and phenotypic characterization, we found that the Actinomyces/Streptococcus coaggregation is only abolished by deletion of cafA. Subsequent biochemical and cytological experiments revealed that CafA constitutes the tip of a unique form of the type 2 fimbria long known for its role in coaggregation. The direct and predominant role of CafA in adherence is evident from the fact that CafA or an antibody against CafA inhibits coaggregation, whereas the shaft protein FimA or a polyclonal antibody against FimA has no effect. Remarkably, FimA polymerization was blocked by deletion of genes for both CafA and FimB, the previously described tip protein of the type 2 fimbria. Together, these results indicate that some surface proteins not linked to a pilus gene cluster in Gram-positive bacteria may hijack the pilus. These unique tip proteins displayed on a common pilus shaft may serve distinct physiological functions. Furthermore, the pilus shaft assembly in Gram-positive bacteria may require a tip, as is true for certain Gram-negative bacterial pili.
Skeletal muscle response to exercise training in congestive heart failure.

To examine the ability of the skeletal muscle of congestive heart failure (CHF) patients to adapt to chronic exercise, five patients performed localized nondominant wrist flexor training for 28 d. Inorganic phosphate (Pi) and phosphocreatine (PCr) were monitored by magnetic resonance spectroscopy in both forearms at rest and during submaximal wrist flexion exercise at 6, 12, 24, and 36 J.min-1 before and after exercise training. Simultaneous measurements of limb blood flow were made by plethysmography at 12, 24, and 36 J.min-1. Forearm muscle mass and endurance were measured by magnetic resonance imaging and wrist flexion exercise before and after training. The Pi/PCr ratio and pH were calculated from the measured Pi and PCr. Exercise cardiac output, heart rate, plasma norepinephrine, and lactate measured during training were not elevated above resting values, confirming that training was localized to the forearm flexor muscles. After training, muscle bioenergetics, as assessed by the slope of the regression line relating Pi/PCr to submaximal workloads, were improved in the trained forearm of each patient, although muscle mass, limb blood flow, and pH were unchanged. Forearm endurance increased by greater than 260% after training. In the dominant untrained forearm, none of the measured indices were affected. We conclude that localized forearm exercise training in CHF patients improves muscle energetics at submaximal workloads in the trained muscle, an effect which is independent of muscle mass, limb blood flow, or a central cardiovascular response during training. These findings indicate that peripheral muscle metabolic and functional abnormalities in CHF can be improved without altering cardiac performance.
Effective and Environmentally Friendly Nickel Coating on the Magnesium Alloy

The low density and good mechanical properties make magnesium and its alloys attractive construction materials in the electronics, automotive, and aerospace industry, together with application in medicine due to their biocompatibility. Magnesium AZ91D alloy is an alloy with a high content of aluminum, whose mechanical properties overshadow the low corrosion resistance caused by the composition of the alloy and the existence of two phases: α magnesium matrix and β magnesium aluminum intermetallic compound. To improve the corrosion resistance, it is necessary to find an effective protection method for the alloy surface. Knowing and predicting electrochemical processes is an essential for the design and optimization of protective coatings on magnesium and its alloys. In this work, the formations of nickel protective coatings on the magnesium AZ91D alloy surface by electrodeposition and chemical deposition, are presented. For this purpose, environmentally friendly electrolytes were used. The corrosion resistance of the protected alloy was determined in chloride medium using appropriate electrochemical techniques. Characterization of the surface was performed with highly sophisticated surface-analytical methods.
Shrinking the Tube: A New Support Vector Regression Algorithm with Parametric Insensitive Model

A new algorithm for support vector regression is described. For a priori chosen v, it automatically adjusts a flexible tube of arbitrary shape and minimal radius to include the data such that at most a fraction v of the data points lie outside. Moreover, it is shown how to use parametric tube shapes with non-constant radius. The algorithm is analysed theoretically and experimentally.
Barriers to incident reporting in a healthcare system

Background: Learning from mistakes is key to maintaining and improving the quality of care in the NHS. This study investigates the willingness of healthcare professionals to report the mistakes of others. Methods: The questionnaire used in this research included nine short scenarios describing either a violation of a protocol, compliance with a protocol, or improvisation (where no protocol exists). By developing different versions of the questionnaire, each scenario was presented with a good, poor, or bad outcome for the patient. The participants (n=315) were doctors, nurses, and midwives from three English NHS trusts who volunteered to take part in the study and represented 53% of those originally contacted. Participants were asked to indicate how likely they were to report the incident described in each scenario to a senior member of staff. Results: The findings of this study suggest that healthcare professionals, particularly doctors, are reluctant to report adverse events to a superior. The results show that healthcare professionals, as might be expected, are most likely to report an incident to a colleague when things go wrong (F(2,520) = 82.01, p<0.001). The reporting of incidents to a senior member of staff is also more likely, irrespective of outcome for the patient, when the incident involves the violation of a protocol (F(2,520) = 198.77, p<0.001. It appears that, although the reporting of an incident to a senior member of staff is generally not very likely, particularly among doctors, it is most likely when the incident represents the violation of a protocol with a bad outcome. Conclusions: An alternative means of organisational learning that relies on the identification of system (latent) failures before, rather than after, an adverse event is proposed.
Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the management of schizophrenia and related disorders

Objectives: This guideline provides recommendations for the clinical management of schizophrenia and related disorders for health professionals working in Australia and New Zealand. It aims to encourage all clinicians to adopt best practice principles. The recommendations represent the consensus of a group of Australian and New Zealand experts in the management of schizophrenia and related disorders. This guideline includes the management of ultra-high risk syndromes, first-episode psychoses and prolonged psychoses, including psychoses associated with substance use. It takes a holistic approach, addressing all aspects of the care of people with schizophrenia and related disorders, not only correct diagnosis and symptom relief but also optimal recovery of social function. Methods: The writing group planned the scope and individual members drafted sections according to their area of interest and expertise, with reference to existing systematic reviews and informal literature reviews undertaken for this guideline. In addition, experts in specific areas contributed to the relevant sections. All members of the writing group reviewed the entire document. The writing group also considered relevant international clinical practice guidelines. Evidence-based recommendations were formulated when the writing group judged that there was sufficient evidence on a topic. Where evidence was weak or lacking, consensus-based recommendations were formulated. Consensus-based recommendations are based on the consensus of a group of experts in the field and are informed by their agreement as a group, according to their collective clinical and research knowledge and experience. Key considerations were selected and reviewed by the writing group. To encourage wide community participation, the Royal Australian and New Zealand College of Psychiatrists invited review by its committees and members, an expert advisory committee and key stakeholders including professional bodies and special interest groups. Results: The clinical practice guideline for the management of schizophrenia and related disorders reflects an increasing emphasis on early intervention, physical health, psychosocial treatments, cultural considerations and improving vocational outcomes. The guideline uses a clinical staging model as a framework for recommendations regarding assessment, treatment and ongoing care. This guideline also refers its readers to selected published guidelines or statements directly relevant to Australian and New Zealand practice. Conclusions: This clinical practice guideline for the management of schizophrenia and related disorders aims to improve care for people with these disorders living in Australia and New Zealand. It advocates a respectful, collaborative approach; optimal evidence-based treatment; and consideration of the specific needs of those in adverse circumstances or facing additional challenges.
The influence of teacher practice on calculus students' motivation

This quantitative study investigated two correlations among Calculus II students’ perceptions of their instructors’ teaching styles. The first was between student motivation and instructor immediacy behaviors and teaching styles. The second correlation was between student effort attributions and instructor immediacy behaviors and teaching styles. Instructor immediacy behaviors include nonverbal and verbal; teaching styles include instructor affect—how positive the teacher appears to be with the class and mathematics—assigned group work and application problems. Students in a large Southwestern research university were surveyed at the start and end of a semester. A significant positive correlation was found between student motivation and instructor behaviors and teaching styles. The three strongest correlations were between student motivation and teacher affect as well as verbal and nonverbal immediacy behaviors. In addition, there was not a significant correlation between student effort attributions and instructor behaviors and teaching styles. These results have implications for instructors teaching a Calculus II type class. Instructors may be advised to exhibit a more positive immediacy behavior as well as have a positive attitude towards the class and mathematics. Further studies may involve other subject levels of mathematics and within different types of institutions.
The surface of Syrtis Major - Composition of the volcanic substrate and mixing with altered dust and soil

Syrtis Major is an old, low relief volcanic plateau near the equatorial regions of Mars. It is a persistent low-albedo feature on the planet and is thought to contain a high abundance of exposed bedrock and/or locally derived surface material and debris. Spatially resolved variations in surface spectral properties, and therefore composition, are investigated with data from the Imaging Spectrometer for Mars (ISM) instrument. ISM obtained 128 wavelength channel spectra from 0.76 to 3.16 μm for contiguous pixels approximately 22 × 22 km in size across much of the plateau. The value and spatial distribution of four primary spectral variables (albedo, continuum slope, wavelength of the ferric-ferrous band minimum, area of the ferric-ferrous absorption) are mapped and coregistered to Viking digital photomosaics. Analysis of these maps shows that although there is a high degree of overall spectral variability on the plateau, the key indicators of mafic mineralogy are relatively homogeneous. Detailed examination of reflectance spectra from representative areas across the plateau indicate the volcanic surface is dominated by augite-bearing basalts and the pyroxene composition in the basalts is estimated to be 0.275± 0.075 Ca/(Ca+Fe+Mg) and 0.3± 0.1 Fe/(Fe+Ca+Mg). Additional mineral components may include olivine, feldspar, and glass. Most of the spectral variability on the plateau is interpreted to result from mixing of volcanic bedrock and/or locally derived surface material and debris with highly altered dust and soil. In western Syrtis Major the altered material is a transient component on the surface or occurs in large spatially coherent patches (e.g., crater rims). In eastern Syrtis Major it is apparent that the dust components are firmly fixed to the basaltic substrate as a stable oxide rind or coating.
SVM incrémental, parallèle et distribué pour le traitement de grandes quantités de données

Résumé. Nous présentons un nouvel algorithme de SVM (Support Vector Machine ou Séparateur à Vaste Marge) linéaire et non-linéaire, parallèle et distribué permettant le traitement de grands ensembles de données dans un temps restreint sur du matériel standard. A partir de l’algorithme de NewtonGSVM proposé par Mangasarian, nous avons construit un algorithme incrémental, parallèle et distribué permettant d’améliorer les performances en temps d’exécution et mémoire en s’exécutant sur un groupe d’ordinateurs. Ce nouvel algorithme a la capacité de classifier un million d’individus en 20 dimensions et deux classes en quelques secondes sur un ensemble de dix PC.