Miracle-dz/UniFAR-FTUs huggingface dataset:
Personality Influences the Relationship Between Primary Emotions and Religious/Spiritual Well-Being

The study of human emotions and personality provides valuable insights into the parameters of mental health and well-being. Affective neuroscience proposes that several levels of emotions – ranging from primary ones such as LUST or FEAR up to higher emotions such as spirituality – interact on a neural level. The present study aimed to further explore this theory. Furthermore, we hypothesized that personality – formed by bottom-up primary emotions and cortical top-down regulation – might act as a link between primary emotions and religious/spiritual well-being. A total sample of 167 (78% female) student participants completed the Affective Neuroscience Personality Scale (primary emotions), the Big Five Personality Inventory and the Multidimensional Inventory of Religious/Spiritual Well-Being (higher emotions). Correlation analyses confirmed the link between primary and higher emotions as well as their relation to personality. Further regression analyses indicated that personality dimensions mediate the relationship between primary and higher emotions. A substantial interaction between primary emotions, personality dimensions, and religious/spiritual well-being could be confirmed. From a developmental perspective, cortical top-down regulation might influence religious/spiritual well-being by forming relevant personality dimensions. Hence, CARE as well as Agreeableness seem of special importance. Future studies might focus on implications for clinical groups.
Robustness in view-graph SLAM

This paper presents a new robustification procedure for nonlinear least-squares optimisation problems. In particular, we focus on the robustness of view-graph SLAM against outlier correspondences in the images and outlier geometries in the graph. Our method utilises revised measurements model linearisation and decision making to detect and remove outliers during data fusion. We utilise innovations and residuals gating to decide which observations were affected, given the most recent model linearisation point. By exploiting the inherited locality of measurements and states and the sparsity structure of nonlinear least-squares formulation we can check which measurement is affected before and after data fusion. This locality is the whole basis of robustification. To be efficient, we carry out the estimation using the information form. By doing so, we can include and remove information by individual measurements at each step using simple information addition and subtraction operations. Our results demonstrate the robustness of our method against outliers with respect to the use of kinematics alone and RANSAC with Levenberg-Marquardt algorithm.
A High-Speed Low-Complexity Modified  ${\rm Radix}-2^{5}$ FFT Processor for High Rate WPAN Applications

This paper presents a high-speed low-complexity modified radix-25 512-point fast Fourier transform (FFT) processor using an eight data-path pipelined approach for high rate wireless personal area network applications. A novel modified radix-25 FFT algorithm that reduces the hardware complexity is proposed. This method can reduce the number of complex multiplications and the size of the twiddle factor memory. It also uses a complex constant multiplier instead of a complex Booth multiplier. The proposed FFT processor achieves a signal-to-quantization noise ratio of 35 dB at 12 bit internal word length. The proposed processor has been designed and implemented using 90-nm CMOS technology with a supply voltage of 1.2 V. The results demonstrate that the total gate count of the proposed FFT processor is 290 K. Furthermore, the highest throughput rate is up to 2.5 GS/s at 310 MHz while requiring much less hardware complexity.
Revealing the Hyperdiverse Mite Fauna of Subarctic Canada through DNA Barcoding

Although mites are one of the most abundant and diverse groups of arthropods, they are rarely targeted for detailed biodiversity surveys due to taxonomic constraints. We address this gap through DNA barcoding, evaluating acarine diversity at Churchill, Manitoba, a site on the tundra-taiga transition. Barcode analysis of 6279 specimens revealed nearly 900 presumptive species of mites with high species turnover between substrates and between forested and non-forested sites. Accumulation curves have not reached an asymptote for any of the three mite orders investigated, and estimates suggest that more than 1200 species of Acari occur at this locality. The coupling of DNA barcode results with taxonomic assignments revealed that Trombidiformes compose 49% of the fauna, a larger fraction than expected based on prior studies. This investigation demonstrates the efficacy of DNA barcoding in facilitating biodiversity assessments of hyperdiverse taxa.
SentiCorr: Multilingual Sentiment Analysis of Personal Correspondence

We present the system for automated sentiment analysis on multilingual user generated content from various social media and e-mails. One of the main goals of the system is to make people aware how much positive and negative content they read and write. The output is summarized into a database allowing for basic OLAP style exploration of the data across basic dimensions including for example time and correspondents dimensions. The sentiment analysis is based on a four-step approach including language identification for short texts, part-of-speech tagging, subjectivity detection and polarity detection techniques. We extensively tested our system on data from Twitter, Face book and Hyves. We also developed an MS Outlook sentiment analysis plug-in allowing people to see how positive or negative the content of the e-mails is and provide confirmatory or correcting feedback on the correctness of the sentiment classification at the sentence or e-mail level.
Restraint stress differentially regulates inflammation and glutamate receptor gene expression in the hippocampus of C57BL/6 and BALB/c mice

Abstract The inbred mouse strains, C57BL/6 and BALB/c have been used widely in preclinical psychiatric research. The differences in stress susceptibility of available strains has provided a useful platform to test pharmacological agents and behavioral responses. Previous brain gene profiling efforts have indicated that the inflammation and immune response gene pathway is the predominant gene network in the differential stress response of BALB/c and C57BL/6 mice. The implication is that a composite stress paradigm that includes a sequence of extended, varied and unpredictable stressors induces inflammation-related genes in the hippocampus. We hypothesized that the regulation of inflammation genes in the brain could constitute a primary stress response and tested this by employing a simple stress protocol, repeated exposure to the same stressor for 10 days, 2 h of restraint per day. We examined stress-induced regulation of 13 proinflammatory cytokine genes in male BALB/c and C57BL/6 mice using quantitative PCR. Elevated cytokine genes included tumor necrosis factor alpha (TNFα), interleukin 6 (IL6), interleukin 10 (IL10), tumor necrosis factor (TNF) super family members and interleukin 1 receptor 1 (IL1R1). In addition, we examined restraint stress-induced regulation of 12 glutamate receptor genes in both strains. Our results show that restraint stress is sufficient to elevate the expression of inflammation-related genes in the hippocampus of both BABLB/c and C57BL/6 mice, but they differ in the genes that are induced and the magnitude of change. Cell types that are involved in this response include endothelial cells and astrocytes. Lay summary Repeated exposure to a simple restraint stress altered the activities of genes involved in inflammation and the functions of the excitatory neurotransmitter, glutamate. These changes in the hippocampus of the mouse brain showed differences that were dependent on the strain of mice and the length of the stress exposure. The effects of stress on activity of these genes may lead to alterations in behavior.
Incidence rates of malignant diseases in childhood and adolescence in children to Swedish fishermen

In this register-based study the risks of childhood malignant diseases in the offspring of Swedish fishermen were analysed. Having a fisherman as a parent was used as surrogate for exposure, both pre- and postnatal, to Persistent Organic Pollutants (POPs) due to high fish consumption. A cohort of fishermen was identified by Statistics Sweden by using the national census registration carried out from 1960 to 1990. For each fisherman, 4 matched – population-based referents were drawn. The children of fishermen and referents were identified and matched against the Swedish cancer registry 1960-1998, the causes of death registry 1960-1997 and notifications of deaths 1998-1999. Children diagnosed with cancer before the parent appeared in the census were excluded. Mantel- Haenszel analysis, adjusted for age and gender, was performed. Incidence rate ratios (IRR) and 95% Confidence Intervals (CI) for the different malignant diagnoses in children 0 to 19 years old were calculated. Fishermen children had an overall increased incidence rate ratio of cancer, IRR=1.38, 95% CI=0.96-2.00. An increased incidence rate ratio was observed for acute lymphatic leukaemia (ALL), IRR=2.65, 95% CI=1.005-6.97, and in west coast children for non-Hodgkin’s lymphoma, IRR=3.19, 95% CI=0.98-10.4. The importance of exposure to POPs to these findings needs further investigation.
Abstract P381: Impact Of Switching From Different Treatment Regimens To A Fixed-dose Combination Pill (Polypill) In Patients With Cardiovascular Disease Or Similarly High Risk

Aims: Cardiovascular fixed-dose combination (FDC) pills, or polypills, may help address the large treatment gaps that exist among patients with cardiovascular disease or similarly high risk. Initiation of polypill-based care in this group typically entails switching from current separately taken medications. Given the heterogeneity in usual care, there is interest in the impact of polypill treatment across different prior medication regimens. Methods: This abstract describes effects of a polypill-based treatment strategy, according to baseline anti platelet, statin and blood pressure (BP)-lowering therapy, in a randomized clinical trial among 2004 participants from India and Europe. The main eligibility criteria were established cardiovascular disease or estimated five year cardiovascular risk of ≥15%. Participants were randomly assigned to a polypill-based treatment strategy or usual care. In the polypill group, physicians could use a polypill that contained aspirin 75 mg, simvastatin 40 mg, lisinopril 10 mg and either atenolol 50 mg or hydrochlorothiazide 12.5 mg. Baseline medication was reviewed and coded into categories. Statin therapy was defined as less potent than the polypill if estimated LDL-cholesterol reduction was 40%. Estimated cardiovascular risk reduction was calculated by combining risk factor changes with results seen in meta-analyses of previous randomized trials. Results: The effect of the polypill at twelve months was relatable to baseline statin usage, with LDL differences of -0.37, -0.22, -0.14 and -0.07 mmol/L compared to continuing usual care among patients taking no statin, less potent, equipotent and more potent statin at baseline, respectively. Similarly there were differences in systolic BP of -5.4, -6.2, -3.3 and -1.8 mmHg among patients taking 0, 1, 2 or ≥3 BP-lowering agents. Among patients taking more potent statins at baseline, there was no significant difference in LDL-cholesterol but there were benefits for BP and aspirin adherence. Similarly, among patients taking ≥3 BP-lowering agents, there were no differences in BP, but benefits for LDL-cholesterol and aspirin adherence. As a result, there were estimated cardiovascular relative risk reductions across all subgroups defined by baseline medication usage. Conclusion: Adherence benefits from switching to a polypill resulted in risk factor changes that were at least as good as usual care, even when usual care involved more potent regimens. More importantly, switching to a polypill-based strategy resulted in estimated cardiovascular relative risk reductions across a wide range of usual care patterns of antiplatelet, statin and BP-lowering therapy prescribing.
Survivin protects fused cancer cells from cell death

Tetraploidy, a potential precursor of cancer-associated aneuploidy, is produced either by cell fusion or failure of cytokinesis. In this study, low p53-expressing HeLa cells were used to address the fate of cancer cells after fusion. We found that massive cell death or growth arrest occurred a few days after fusion. Interestingly, cells with larger nuclei preferentially died after fusion, suggesting that a larger deviation of DNA content is a strong inducer of apoptosis. Notably, a fraction of cells escaped cell death. Also, the stability of survivin increased, and its localization changed preferentially to the cytosol in fused cells. Knockdown of survivin decreased the survival of fused cells, more than observed in unfused cells, showing increased dependency of fused cells on survivin. Collectively, after cancer cell fusion, some fused cells avoid the apoptotic crisis partly owing to survivin, and continue to proliferate, a process that contributes to human cancer progression.
Parameter and contact force estimation of planar rigid-bodies undergoing frictional contact

This paper addresses the identification of the inertial parameters and the contact forces associated with objects making and breaking frictional contact with the environment. Our goal is to explore under what conditions, and to what degree, the observation of physical interaction, in the form of motions and/or applied external forces, is indicative of the underlying dynamics that governs it. In this study we consider the cases of passive interaction, where an object free-falls under gravity, and active interaction, where known external perturbations act on an object at contact. We assume that both object and environment are planar and rigid, and exploit the well-known complementarity formulation for contact resolution to establish a constrained optimization-based problem to estimate inertial parameters and contact forces. We also show that when contact modes are known, or guessed, the formulation provides a closed-form relationship between inertial parameters, contact forces, and observed motions, that turns into a least squares problem. Consistent with intuition, the analysis indicates that without the application of known external forces, the identifiable set of parameters remains coupled, i.e. the ratio of mass moment of inertia to mass and the ratio of contact forces to the mass. Interestingly the analysis also shows that known external forces can lead to decoupling and identifiability of mass, mass moment of inertia, and normal and tangential contact forces. We evaluate the proposed algorithms both in simulation and with real experiments for the cases of a free falling square, ellipse, and rimless wheel interacting with the ground, as well as a disk interacting with a manipulator.
Comprehensive and Quantitative Mapping of Energy Landscapes for Protein-Protein Interactions by Rapid Combinatorial Scanning*♦

A novel, quantitative saturation (QS) scanning strategy was developed to obtain a comprehensive data base of the structural and functional effects of all possible mutations across a large protein-protein interface. The QS scan approach was applied to the high affinity site of human growth hormone (hGH) for binding to its receptor (hGHR). Although the published structure-function data base describing this system is probably the most extensive for any large protein-protein interface, it is nonetheless too sparse to accurately describe the nature of the energetics governing the interaction. Our comprehensive data base affords a complete view of the binding site and provides important new insights into the general principles underlying protein-protein interactions. The hGH binding interface is highly adaptable to mutations, but the nature of the tolerated mutations challenges generally accepted views about the evolutionary and biophysical pressures governing protein-protein interactions. Many substitutions that would be considered chemically conservative are not tolerated, while conversely, many non-conservative substitutions can be accommodated. Furthermore, conservation across species is a poor predictor of the chemical character of tolerated substitutions across the interface. Numerous deviations from generally accepted expectations indicate that mutational tolerance is highly context dependent and, furthermore, cannot be predicted by our current knowledge base. The type of data produced by the comprehensive QS scan can fill the gaps in the structure-function matrix. The compilation of analogous data bases from studies of other protein-protein interactions should greatly aid the development of computational methods for explaining and designing molecular recognition.
MRI of the tumor microenvironment

The microenvironment within tumors is significantly different from that in normal tissues. A major difference is seen in the chaotic vasculature of tumors, which results in unbalanced blood supply and significant perfusion heterogeneities. As a consequence, many regions within tumors are transiently or chronically hypoxic. This exacerbates tumor cells' natural tendency to overproduce acids, resulting in very acidic pH values. The hypoxia and acidity of tumors have important consequences for antitumor therapy and can contribute to the progression of tumors to a more aggressive metastatic phenotype. Over the past decade, techniques have emerged that allow the interrogation of the tumor microenvironment with high resolution and molecularly specific probes. Techniques are available to interrogate perfusion, vascular distribution, pH, and pO2 nondestructively in living tissues with relatively high precision. Studies employing these methods have provided new insights into the causes and consequences of the hostile tumor microenvironment. Furthermore, it is quite exciting that there are emerging techniques that generate tumor image contrast via ill‐defined mechanisms. Elucidation of these mechanisms will yield further insights into the tumor microenvironment. This review attempts to identify techniques and their application to tumor biology, with an emphasis on nuclear magnetic resonance (NMR) approaches. Examples are also discussed using electron MR, optical, and radionuclear imaging techniques. J. Magn. Reson. Imaging 2002;16:430–450. © 2002 Wiley‐Liss, Inc.
Aging in the Craniofacial Complex Longitudinal Dental Arch Changes Through the Sixth Decade Marcus

Objective: To describe the dental arch changes occurring after adolescence through the sixth decade of life. Materials and Methods: Longitudinal dental casts from 40 patients (20 male and 20 female) were digitized and analyzed. Measurements were recorded after the presumed cessation of circumpubertal growth (T1), at approximately 47 years of age (T2), and at least one decade later (T3) were compared. Results: The majority of the measurements were found to have a significant time effect, demonstrating at least some level of change throughout the aging process (T1–T3). Exceptions to this observation were the posterior maxillary arch width measurements, mandibular intermolar and interpremolar (as measured at the second premolars) widths, the maxillary incisor irregularity index, overjet, overbite, and curve of Spee. The T1–T3 changes reflected for the most part the T1– T2 changes, while the T2–T3 changes affected overall modifications only for the mandibular intercanine width and maxillary depth, as measured at the second premolars. All changes reflected a decrease in arch width, depth, and perimeter, with a significant increase in the mandibular incisor irregularity index. Conclusions: The dental arches continue to change and adapt throughout life and into the sixth decade, though the degree of change decreases with time.
Performance Analysis of Distributed MIMO With ZF Receivers Over Semi-Correlated $\mathcal {K}$ Fading Channels

Distributed multiple-input multiple-output (D-MIMO) systems have drawn considerable attention as they can combine the advantages of point-to-point MIMO with distributed antenna system (DAS). However, the performance analysis of D-MIMO system with zero-forcing (ZF) receivers over semi-correlated <inline-formula> <tex-math notation="LaTeX">$\mathcal {K}$ </tex-math></inline-formula> fading channels involves special functions, such as Bessel and Meijer-G functions, which do not enable us to further analysis. In this paper, by using moment matching method, we present a new method that use a Gamma distribution to approximate the <inline-formula> <tex-math notation="LaTeX">$\mathcal {K}$ </tex-math></inline-formula> distribution (Rayleigh/Gamma distribution). Using the approximate distribution as a starting point, we derive the approximate analytical expressions on the achievable sum rate (ASR), symbol error ratio (SER), and outage probability (OP) of D-MIMO systems operating in semi-correlated <inline-formula> <tex-math notation="LaTeX">$\mathcal {K}$ </tex-math></inline-formula> fading channels employing ZF receivers. To get useful insight into implications of system and fading parameters on the performance, the analytical asymptotic approximations on the ASR in high signal-to-noise ratio (SNR) and low-SNR regime are provided, respectively. Finally, we perform the approximate large-system analysis in the high-SNR and provide asymptotic sum rate expressions when the number of antennas at the base station (BS) grows large, and when the number of antennas at both ends grows large with a fixed and finite ratio. It is demonstrated that the proposed approximate expressions accurately match with the analytical expressions, especially for large-system limit.
Expression of E6/E7 HPV-DNA, HPV-mRNA and colposcopic features in management of CIN2/3 during pregnancy.

OBJECTIVE The incidence of abnormal cervical cytology in pregnancy is similar to that reported for non-pregnant women. Furthermore, 1% of pregnant women annually screened for cervical cancer will be diagnosed with cervical intraepithelial neoplasia (CIN) of various degrees. For this reason, Pap smear should be performed in the first trimester of pregnancy. The persistence of HR-HPV infection is related to the development of CIN. However, the relationship between CIN and HR-HPV infection during pregnancy and postpartum can hardly be found. The aim of this work was to assess the proper management of abnormal cytology during and after pregnancy evaluating regression rate, persistence rate and risk of progression and the predictive role of HPV molecular tests. PATIENTS AND METHODS Patients with abnormal cervical cytology were followed-up using colposcopy and colposcopy-directed biopsies every 12 weeks. Molecular tests were performed at the moment of the cytological diagnosis. Patients not treated in pregnancy were re-evaluated with cytology, colposcopy, biopsies, HPV-DNA test and HPV-mRNA test for a final diagnosis 8 weeks postpartum. Women with a persistent CIN 2-3 lesion at this follow-up check, underwent an excisional procedure by LEEP and then re-evaluated every 6 months for a year. RESULTS HPV-DNA test showed a sensitivity of 90.5% and a negative predictive value of 96.4%. Specificity and positive predictive values were 67.9% and 43.2%, respectively. For HPV-mRNA test, a sensitivity of 76.2% and a NPV of 93.9% were found; specificity and PPV were 98.7% and 94.1% respectively. CONCLUSIONS An observational management based on the use of molecular test and particularly HPV-mRNA test for its higher specificity, is a reasonable possibility in the follow-up of CIN2/3 lesions during pregnancy.