Miracle-dz/UniFAR-FTUs huggingface dataset:
Little effect of insurance status or socioeconomic condition on disparities in minority appendicitis perforation rates.

OBJECTIVE To estimate how much of the gap in appendicitis perforation rates between minority and white children is explained by differences in socioeconomic and insurance factors. DESIGN Observational analysis of hospital discharge information. SETTING The Healthcare Cost and Utilization Project database. PARTICIPANTS Appendicitis perforation rates determined from the Healthcare Cost and Utilization Project database of hospital discharges from 2001 to 2008. MAIN OUTCOME MEASURES The proportion of the gap between perforation rates explained by various patient- and hospital-level variables. RESULTS There were no disparities observed in adult appendicitis perforation rates. The perforation rate for white children was 26.7%; black children, 35.5%; and Latino children, 36.5%. Gap analysis showed that only 12.0% of the difference in perforation rates between black and white children was explained by insurance status and only 12.7% of the difference between Latino and white children was explained. Income level only accounted for 7.2% of the gap for black children and 6.1% for Latino children. Age explained one-third of the gap for Latino children and one-third was not accounted for by measurable variables. Two-thirds of the difference between appendicitis perforation rates between black and white children was not explained by measurable factors. CONCLUSIONS A very small amount of the gap between minority and white children's appendicitis rates is explained by the proxy factors for health insurance and poverty status that might relate to health care access. Appendicitis perforation rates are not an appropriate indicator of health care access.
Microbial reductive dechlorination of trichloroethene to ethene with electrodes serving as electron donors without the external addition of redox mediators

In situ bioremediation of industrial chlorinated solvents, such as trichloroethene (TCE), is typically accomplished by providing an organic electron donor to naturally occurring dechlorinating populations. In the present study, we show that TCE dechlorinating bacteria can access the electrons required for TCE dechlorination directly from a negatively polarized (−450 mV vs. SHE) carbon paper electrode. In replicated batch experiments, a mixed dechlorinating culture, also containing Dehalococcoides spp. , dechlorinated TCE to cis‐dichloroethene (cis‐DCE) and lower amounts of vinyl chloride (VC) and ethene using the polarized electrode as the sole electron donor. Conversely, neither VC nor ethene formation occurred when a pure culture of the electro‐active microorganism Geobacter lovleyi was used, under identical experimental conditions. Cyclic voltammetry tests, carried out on the filter‐sterilized supernatant of the mixed culture revealed the presence of a self‐produced redox mediator, exhibiting a midpoint potential of around −400 mV (vs. SHE). This yet unidentified redox‐active molecule appeared to be involved in the extracellular electron transfer from the electrode to the dechlorinating bacteria. The ability of dechlorinating bacteria to use electrodes as electron donors opens new perspectives for the development of clean, versatile, and efficient bioremediation systems based on a controlled subsurface delivery of electrons in support of biodegradative metabolisms and provides further evidence on the possibility of using conductive materials to manipulate and control a range of microbial bioprocesses. Biotechnol. Bioeng. 2009;103: 85–91. © 2008 Wiley Periodicals, Inc.
Investigation of Localised Pressure Applied to Specific Sites on the Lateral Aspect of the Foot’s Dorsum by the Upper Parts of Footwear During Sports Specific Movements

Purpose: Localised peak pressure linked to overuse injuries has been documented extensively at the plantar surface during human locomotion. There is however a paucity of research investigating pressure applied to non-plantar regions of the foot during movement. This study investigates the magnitudes of peak pressures applied to the lateral side of the 5th metatarsal head (5MTH) and calcaneus (CC) by the uppers of footwear during sports movements. Method: A plantar pressure measuring system was adapted to fit into a sock covering the lateral aspect of the L5MTH and LCC. Six male participants (26.7 ± 2.4 years, 75.2 ± 5.5 kg) performed ten trials each of starting, stopping, sprinting, cutting and sidestepping at self-selected velocities, whilst wearing the pressure measuring device. Repeated measures ANOVAs were used to examine differences between peak pressures at different aspects of the lateral side of the dorsum of the foot Results: The results indicate significant differences (p 0.05) were reported at the LCC between different movements. Conclusions: The results identify a need for athletes pre-disposed to injuries in the uppers of the feet to consider the possible influence of footwear on the magnitudes of peak pressures applied to the lateral side of the dorsum of their feet.
Robust Predictive Control using a GOBF Model for MISO Systems

In this paper we develop a new method for robust predictive control for MISO systems represented on the generalized orthonormal basis functions. Unknown but bounded error approaches are used to update the uncertainty domain of the resultant model coefficients. This method uses a worst case strategy solved by a min-max optimisation problem taking into account the constraints relative to parameter uncertainties and to measurement signals.
Youth political involvement update: measuring the role of cause-oriented political interest in young people's activism

In recent decades, a series of transformations have occurred that have changed young people's relationships with politics. In most Western countries, young people vote less and protest more. Survey research has detected this two-fold process in participation behaviour, but has failed to detect this same process in the field of political attitudes. In particular, the emergence of a specific dimension of psychological political involvement with a special impact on youth has gone unnoticed in survey-based research. Based on some recent qualitative studies, this research tries to identify and measure a specific dimension of interest in politics using a new question in a survey carried out in Catalonia in 2011. An interest directly oriented to political issues and causes – particularly those relevant in young people's everyday lives – is identified. The article also evaluates how traditional survey indicators of political involvement do capture, or not, this particular dimension of interest in politics. Finally, the new cause-oriented interest indicator is tested to analyse its impact on different types of participation in order to better understand patterns of activism in young people.
Clinical significance of circulating immune complexes in ‘lone’ cryptogenic fibrosing alveolitis and those with associated connective tissue disorders

The clinical, radiographic and physiological features, and progression rates of forty unselected patients with cryptogenic fibrosing alveolitis (CFA) have been studied in relation to serum immune complexes measured by a C1q binding technique. Twenty (50%) had levels greater than normal. Those with associated connective tissue disorders (twenty‐four) had a higher frequency of raised C1q binding than those with ‘lone’ CFA (sixteen) (63% compared to 31%). As observed previously in this group, those with associated disorders also had higher titres of immune complexes. Twelve of thirteen with polyarthritis had immune complexes and a considerably shorter duration of disease compared with those without joint symptoms (P<0.0l).
Human Papillomavirus and Tobacco Use in Tongue Base Cancers

Human papillomavirus 16 (HPV-16) infection and tobacco use are associated with human oropharyngeal cancers. We conducted a study of the role of HPV and tobacco use in base of the tongue (BOT) cancers. DNA from 34 such cancers was subjected to HPV-16 and HPV-18-specific polymerase chain reaction analysis. Demographic and clinicopathologic data were obtained from each patient's medical record. HPV-16 was detected in 68% of tumors. Tobacco use was the only factor found to be significantly associated with HPV status. Tumors from 100% of patients who had never use d tobacco tested positive for HPV, compared with only 56% of those who had ever used tobacco (Fisher exact test, p = 0.024). All tumors were associated with either tobacco use or HPV infection. These findings are consistent with the hypothesis that either tobacco use or HPV infection is necessary to the etiology of BOT tumors, and they suggest that tongue base carcinoma may be prevented by combining HPV vaccination with tobacco avoidance.
Therapeutic Trial of Vigabatrin in Refractory Infantile Spasms

Infantile spasms usually start during the first year of life and constitute one of the most difficult types of epilepsy to treat. They carry a very poor prognosis for both epilepsy and mental development. Seventy children, including 47 infants, with intractable infantile spasms were entered into an open study with vigabatrin as add-on therapy to the usual anticonvulsant treatment. All were resistant to previous treatments, including corticosteroids (43 patients), carbamazepine, benzodiazepines, and sodium valproate. Two children withdrew from the study because of intolerance to vigabatrin (hypotonia or hypertonia) before evaluation of efficacy could be made. Of the remaining 68 children, 29 (43%) showed complete suppression of spasms. Forty-six children had a greater than 50% reduction in spasms. The best response was observed in those with tuberous sclerosis (12/14 compared with 12/18 with symptomatic infantile spasms of other origin and 22/36 with cryptogenic infantile spasms). Following the initial response to treatment of these patients (n = 68), a long-term response was confirmed in 75% of children with symptomatic infantile spasms and 36% of children with cryptogenic infantile spasms. In eight children, all other anticonvulsant medication could be definitively withdrawn. Tolerability appeared excellent, with 52 of 70 patients reporting no side effects. Somnolence, hypotonia, weight gain, excitation, and insomnia were the most common problems at the beginning of the study and were usually transient. Given the poor prognosis of this type of childhood epilepsy, vigabatrin appears to be a very interesting advance in the management of drug-resistant infantile spasms. (J Child Neurol 1991;6(Suppl):2S52-2S59).
Remote sensing and conservation of isolated indigenous villages in Amazonia

The vast forests on the border between Brazil and Peru harbour a number of indigenous groups that have limited contact with the outside world. Accurate estimates of population sizes and village areas are essential to begin assessing the immediate conservation needs of such isolated groups. In contrast to overflights and encounters on the ground, remote sensing with satellite imagery offers a safe, inexpensive, non-invasive and systematic approach to provide demographic and land-use information for isolated peoples. Satellite imagery can also be used to understand the growth of isolated villages over time. There are five isolated villages in the headwaters of the Envira River confirmed by overflights that are visible with recent satellite imagery further confirming their locations and allowing measurement of their cleared gardens, village areas and thatch roofed houses. These isolated villages appear to have population densities that are an order of magnitude higher than averages for other Brazilian indigenous villages. Here, we report on initial results of a remote surveillance programme designed to monitor movements and assess the demographic health of isolated peoples as a means to better mitigate against external threats to their long-term survival.
Acoustic Droplet Vaporization in Biology and Medicine

This paper reviews the literature regarding the use of acoustic droplet vaporization (ADV) in clinical applications of imaging, embolic therapy, and therapeutic delivery. ADV is a physical process in which the pressure waves of ultrasound induce a phase transition that causes superheated liquid nanodroplets to form gas bubbles. The bubbles provide ultrasonic imaging contrast and other functions. ADV of perfluoropentane was used extensively in imaging for preclinical trials in the 1990s, but its use declined rapidly with the advent of other imaging agents. In the last decade, ADV was proposed and explored for embolic occlusion therapy, drug delivery, aberration correction, and high intensity focused ultrasound (HIFU) sensitization. Vessel occlusion via ADV has been explored in rodents and dogs and may be approaching clinical use. ADV for drug delivery is still in preclinical stages with initial applications to treat tumors in mice. Other techniques are still in preclinical studies but have potential for clinical use in specialty applications. Overall, ADV has a bright future in clinical application because the small size of nanodroplets greatly reduces the rate of clearance compared to larger contrast agent bubbles and yet provides the advantages of ultrasonographic contrast, acoustic cavitation, and nontoxicity of conventional perfluorocarbon contrast agent bubbles.
Organizing Babylon ‐ On the Different Conceptions of Policy Networks

A ‘Babylonian’ variety of policy network concepts and applications can be found in the literature. Neither is there a common understanding of what policy networks actually are, nor has it been agreed whether policy networks constitute a mere metaphor, a method, an analytical tool or a proper theory. The aim of this article is to review the state of the art in the field of policy networks. Special attention is given to the German conception of policy networks which is different from the one predominant in the Anglo-Saxon literature. While British and American scholars usually conceive policy networks as a model of state/society relations in a given issue area, German works tend to treat policy networks as an alternative form of governance to hierarchy and market. It is argued that this conception of policy networks goes beyond serving as a mere analytical tool box for studying public policy-making. Yet, both the German and the Anglo-Saxon conception of policy networks face a common challenge: first, it still remains to be systematically shown that policy networks do not only exist but are really relevant to policy-making, and second, the problem of the ambiguity of policy networks has to be tackled, as policy networks can both enhance and reduce the efficiency and legitimacy of policy-making.
Dextran or Polyethylene Glycol Added to Curosurf for Treatment of Meconium Lung Injury in Rats

Background: In experimental lung injuries, improvement of lung function after treatment with surfactant/polymer mixtures may depend on both type of polymer and the specific surfactant. In vitro studies suggest that dextran is more effective when mixed with Curosurf, and polyethylene glycol (PEG) is more effective when mixed with Survanta. We therefore wanted to find out whether these results held true in an animal model of acute lung injury. Objective:To compare the response to therapy of PEG vs. dextran when added to Curosurf after meconium lung injury. Methods:Lung injury was produced by intratracheal instillation of meconium (30 and 4 ml/kg). One hour after injury, Curosurf (35 mg/ml) with or without 5% dextran (68 kDa) or 5% PEG (10 kDa) was given. Arterial blood gases and peak inspiratory pressures were measured for 3 h after treatment while animals were supported by volume-regulated ventilation. Then animals were sacrificed and pressure volume relationships, lung wet/dry weights, and histology were assessed. Results:Initially, improved PaO2 and inspiratory pressure occurred for both Curosurf/PEG and Curosurf/dextran groups compared with Curosurf, but at three hours, peak inspiratory pressure and PaO2 remained significantly improved for the Curosurf/dextran but not for Curosurf/PEG groups when compared with Curosurf alone. Total lung capacity at the end of the experiment was also significantly increased in the Curosurf/dextran group, but not the Curosurf/PEG group when compared with Curosurf. Conclusion:Under these experimental conditions, Curosurf/dextran mixtures provided a better therapeutic response than Curosurf/PEG or Curosurf.
The meaning of work and employment: Psychological research and psychologists' values

Structural change and its implications for unemployment raise questions about the meaning of work to individuals in our society. This paper examines the status of psychological research on this topic by reviewing four areas of research job satisfaction, effects of unemployment, adult development and the cultural significance of work and employment. The conclusions which can be drawn are limited by conceptual and methodological problems, but it seems that finding substitutes for opportunities for mastery in the work role is a central issue to be addressed in a transition to a low-employment society. Some cautions about the values brought to bear on research in this area are sounded.
Effect of alcohol on dystonia

An intravenous infusion of a 250-ml, 10% ethanol solution decreased dystonic scores in five of seven patients with spasmodic torticollis, but had no effect in patients with Meige syndrome, tardive dystonia, or generalized torsion dystonia. Alcohol may temporarily decrease some forms of dystonia.
A retrospective database analysis of insulin use patterns in insulin-naïve patients with type 2 diabetes initiating basal insulin or mixtures

Objective: To describe insulin persistence among patients with type 2 diabetes initiating insulin therapy with basal insulin or insulin mixtures and determine factors associated with nonpersistence. Research design and methods: The Thomson Reuters MarketScan® databases were used to retrospectively analyze insulin-naïve patients with type 2 diabetes by initiating insulin therapy. Insulin use was described using a variety of measures. The persistence to insulin was described using both a gap-based measure and the number of claims measure. Results: Patients in the basal insulin cohort (N = 15,255) primarily used insulin analogs (88.1%) and vial and syringe (97%). Patients in the mixture cohort (N = 2,732) were more likely to initiate on human insulin mixtures (62.5%) and vial and syringe (68.1%). Average time between insulin refills was 80 and 71 days for basal and mixture initiators, respectively. Nearly, 75% of basal insulin initiators and 65% of insulin mixture initiators had a 90-day gap in insulin prescriptions. More than half of all the patients had at least one insulin prescription per quarter. Patients initiating with insulin analogs were more likely to be persistent compared with those initiating with human insulin across both cohorts and measures of persistence (P < 0.001). Conclusion: Persistence to insulin therapy is poorer than one would anticipate, but appears to be higher in users of insulin analogs and insulin mixtures.
Xe-CT and transcranial doppler in symptomatic vasospasm subarachnoid hemorrhage patients under euvolemic treatment without sedation.

BACKGROUND Delayed cerebral ischemia from cerebral arterial vasospasm following aneurysmal subarachnoid hemorrhage (aSAH) is associated with significant morbidity and mortality. Early recognition of the cerebral arterial vasospasm and institution of appropriate treatment can reduce the consequences. AIM We investigated the association of transcranial Doppler (TCD) and Xe-CT with the characteristics of symptomatic vasospasm secondary to aneurysmal subarachnoid hemorrhage (SAH) in patients who underwent euvolemic treatment without sedation. MATERIALS AND METHODS Data collected prospectively in patients with aSAH admitted to a neurocritical care unit in a regional hospital were retrospectively analyzed. Out of the 98 consecutive patients with aSAH, 30 patients underwent paired Xe-CT (not sedated) and TCD studies. Correlation between cortical cerebral blood flow (CBF) and mean blood flow velocity in middle cerebral artery (MCA) territories was analyzed. The lowest cortical regional CBF and MCA velocity were compared between patients with and without symptomatic vasospasm. RESULTS Symptomatic vasospasm occurred in 12 patients. No correlation was found between CBF and mean blood flow velocity of the MCA territory. The differences between MCA velocity and lowest cortical CBF in patients with symptomatic vasospasm were significantly different from patients without symptoms. CONCLUSION TCD does not help to predict regional CBF in the MCA territory in patients with aSAH on euvolemic treatment.
Increase in Grid-Connected PV System Power in Germany

This paper outlines the preliminary results of our study on the amount of newly-installed photovoltaic power capacity in Germany in 2004. Up to now, the figures published have been based purely on estimates - using sales figures from selected companies as a base. For our survey we have carried out an empirical study: As a result of the feed-in tariffs for solar electricity in effect in Germany, all PV systems are registered with one of the grid operators, and so for this study we have gotten in contact with all 910 grid operators to inquire as to the installed photovoltaic power in their respective service area. Currently, around 83 percent of the targeted group have responded to the survey. The data determined so far demonstrates that the increase in the amount of PV power in 2004 was not, as presumed up to now, 360 MW, but rather 650 MW. Furthermore, the study carried out also shows it is highly likely that the amount of installed PV power overall in Germany totaled more than 1 GW by the end of 2004 (as opposed to 794 MW - the figure stated in current IEA-statistics). At the very least, we can demonstrate that installed photovoltaic power has reached 952 MW - this being a conservative estimate based on the fact our survey is still underway. Were figures to be extrapolated linearly, the amount of installed PV power by the end of 2004 would be 1.15 GW
The validity and reliability of the Violence Risk Scale: A treatment-friendly violence risk assessment tool.

The development of risk assessment tools that use dynamic variables to predict recidivism and to inform and facilitate violence reduction interventions is the next major challenge in the field of risk assessment and management. This study is the first in a 2-step process to validate the Violence Risk Scale (VRS), a risk assessment tool that integrates violence assessment, prediction, and treatment. Ratings of the 6 static and 20 dynamic VRS variables assess the client's level of risk. Ratings of the dynamic variables identify treatment targets linked to violence, and ratings of the stages of change of the treatment targets assess the client's treatment readiness and change. The VRS scores of 918 male offenders showed good interrater reliability and internal consistency and could predict violent and nonviolent recidivism over both short- and longer term (4.4-year) follow-up. The probability of violent and nonviolent recidivism varied linearly with VRS scores. Dynamic and static variables performed equally well. The results support the contention that the VRS can be used to assess violent risk and to guide violence reduction treatment.