Miracle-dz/UniFAR-FTUs huggingface dataset:
Termites in the trading system : how preferential agreements undermine free trade

Jagdish Bhagwati, an internationally renowned economist known for his insightful analyses and elegant writing, here shines a critical light on Preferential Trade Agreements, revealing how the rapid spread of PTAs endangers the world trading system. Preferential Trade Agreements, many taking the form of Free Trade Agreements, now number over 300 and are rapidly increasing. Bhagwati reveals how these agreements have recreated the unhappy situation of the protectionist 1930s, when world trade was undermined by discriminatory practices (today, ironically, as a result of a misdirected pursuit of free trade). The world trading system is definitely at risk again, the author argues, and the danger is palpable. Indeed, PTAs have created a chaotic system of preferences that has destroyed the principle of non-discrimination in trade. The trading system today is characterized by a blizzard of discriminatory barriers, each designed to favor some specific trading partner, so that we have what Bhagwati has called the "spaghetti bowl" problem. And while the big firms in the big countries can cope with the chaos, though at a cost, the author shows that small countries and small exporters are seriously handicapped. He also examines how FTAs are typically tied to extraneous issues such as openness to capital flows and inappropriate labor standards, so that the weaker nations, negotiating one-on-one with stronger nations, are forced to accept harmful demands unrelated to trade. Finally, the book warns that getting to multilateral free trade from the morass of PTAs will be almost an impossible task--like building a mansion from different-sized bricks. Preferential trade agreements, Bhagwati concludes, are not building blocks but stumbling blocks on the road of free trade. In Termites in the Trading System, he illuminates this growing threat to the world trading system. Acclaim for In Defense of Globalization: "If Mr. Bhagwati doesn't get a much deserved Nobel Prize for economics, he should get one for literature. His writing sparkles with anecdotes and delightful verbal pictures. " --New York Sun "One of the world's leading international trade theorists. Accessible and clearly argued. There is, one might say, a wealth of material on every page. " --The Wall Street Journal "An outstandingly effective book. Until further notice In Defense of Globalization becomes the standard general-interest reference, the intelligent layman's handbook, on global economic integration. " --The Economist Available in OSO: http://www.oxfordscholarship. com/oso/public/content/economicsfinance/9780195331653/toc.html
Bounds on the cover time

Consider a particle that moves on a connected, undirected graphG withn vertices. At each step the particle goes from the current vertex to one of its neighbors, chosen uniformly at random. Tocover time is the first time when the particle has visited all the vertices in the graph starting from a given vertex. In this paper, we present upper and lower bounds that relate the expected cover time for a graph to the eigenvalues of the Markov chain that describes the random walk above. An interesting consequence is that regular expander graphs have expected cover time Θ(n logn).
Formal Security Analysis and Improvement of a hash-based NFC M-coupon Protocol

Near field communication (NFC) is a Radio Frequency (RF) technology that allows data to be exchanged between devices that are in close proximity. We formally analyse a hash based NFC mobile coupon protocol using formal methods (Casper/FDR2 ). We discover a few possible attacks which break the requirements of the protocol. We propose solutions to address these attacks based on two different threat models. In addition, this paper is a facilitating case study for a black-box user to become a more powerful analyser.
Charge detection mass spectrometry of bacteriophage P22 procapsid distributions above 20 MDa.

RATIONALE Charge state resolution is required to determine the masses of ions in electrospray mass spectrometry, a feat which becomes increasingly difficult as the mass increases. Charge detection mass spectrometry (CDMS) circumvents this limitation by simultaneously measuring the charge and the m/z of individual ions. In this work, we have used electrospray CDMS to determine the number of scaffolding proteins associated with bacteriophage P22 procapsids. METHODS P22 procapsids containing a native cargo of scaffolding protein were assembled in E. coli and purified via differential centrifugation. Electrospray CDMS was used to measure their mass distribution. RESULTS The procapsid peak was centered at 23.60 MDa, which indicates that they contain an average of ~112 scaffolding proteins. The distribution is relatively narrow, less than 31 scaffolding proteins wide. In addition, a peak at 19.84 MDa with a relative abundance of ~15% is attributed to empty capsids. Despite having the same sizes in solution, the empty capsid and the procapsid have significantly different average charges. CONCLUSIONS The detection of empty capsids is unexpected and the process that leads to them is unknown. The average charge on the empty capsids is significantly lower than expected from the charge residue model, which probably indicates that the empty capsids have contracted in the gas phase. The scaffolding protein presumably limits the contraction of the procapsids. This work shows that electrospray CDMS can provide valuable information for masses greater than 20 MDa.
Concatenated permutation block codes based on set partitioning for substitution and deletion error-control

A new class of permutation codes is presented where, instead of considering one permutation as a codeword, codewords consist of a sequence of permutations. The advantage of using permutations, i.e. their favourable symbol diversity properties, is preserved. Additionally, using sequences of permutations as codewords, code rates close to the optimum rate can be achieved. Firstly, the complete set of permutations is divided into subsets by using set partitioning. Binary data is then mapped to permutations from these subsets. These permutations, together with a parity permutation, will form the codeword. Two constructions will be presented: one capable of detecting and correcting substitution errors and the other capable of detecting and correcting either substitution or deletion errors.
Keys to Cosmology - Clusters of Galaxies

We review several aspects of clusters of galaxies and their application to cosmology. We present first results of numerical simulations of the dynamics of the intra-cluster gas and of different interaction processes between cluster galaxies and the intra-cluster gas. In particular metallicity maps are very useful to determine the importance of the different interaction processes. Also mass determination methods and possible sources for uncertainties in the measurements are shown.
Noncoding RNAs of Trithorax Response Elements Recruit Drosophila Ash1 to Ultrabithorax

Homeotic genes contain cis-regulatory trithorax response elements (TREs) that are targeted by epigenetic activators and transcribed in a tissue-specific manner. We show that the transcripts of three TREs located in the Drosophila homeotic gene Ultrabithorax (Ubx) mediate transcription activation by recruiting the epigenetic regulator Ash1 to the template TREs. TRE transcription coincides with Ubx transcription and recruitment of Ash1 to TREs in Drosophila. The SET domain of Ash1 binds all three TRE transcripts, with each TRE transcript hybridizing with and recruiting Ash1 only to the corresponding TRE in chromatin. Transgenic transcription of TRE transcripts restores recruitment of Ash1 to Ubx TREs and restores Ubx expression in Drosophila cells and tissues that lack endogenous TRE transcripts. Small interfering RNA–induced degradation of TRE transcripts attenuates Ash1 recruitment to TREs and Ubx expression, which suggests that noncoding TRE transcripts play an important role in epigenetic activation of gene expression.
A Stochastic Temporal Model of Polyphonic MIDI Performance with Ornaments

We study indeterminacies in realization of ornaments and how they can be incorporated in a stochastic performance model applicable for music information processing such as score-performance matching. We point out the importance of temporal information, and propose a hidden Markov model which describes it explicitly and represents ornaments with several state types. Following a review of the indeterminacies, they are carefully incorporated into the model through its topology and parameters, and the state construction for quite general polyphonic scores is explained in detail. By analysing piano performance data, we find significant overlaps in inter-onset-interval distributions of chordal notes, ornaments, and inter-chord events, and the data is used to determine details of the model. The model is applied for score following and offline score-performance matching, yielding highly accurate matching for performances with many ornaments and relatively frequent errors, repeats, and skips.
Evaluation of detailed aromatic mechanisms (MCMv3 and MCMv3.1) against environmental chamber data

Abstract. A high quality dataset on the photo-oxidation of benzene, toluene, p-xylene and 1,3,5-trimethylbenzene has been obtained from experiments in the European Photoreactor (EUPHORE), a large outdoor environmental reaction chamber. The experiments were designed to test sensitive features of detailed aromatic mechanisms, and the dataset has been used to evaluate the performance of the Master Chemical Mechanism Version 3 (MCMv3). An updated version (MCMv3.1) was constructed based on recent experimental data, and details of its development are described in a companion paper. The MCMv3.1 aromatic mechanisms have also been evaluated using the EUPHORE dataset. Significant deficiencies have been identified in the mechanisms, in particular: 1) an over-estimation of the ozone concentration, 2) an under-estimation of the NO oxidation rate, 3) an under-estimation of OH. The use of MCMv3.1 improves the model-measurement agreement in some areas but significant discrepancies remain.
Pectinolytic and Cellulolytic Enzymes Enhance Fusarium compactum Virulence on Tubercles Infection of Egyptian Broomrape

The use of enzyme could facilitate pathogen penetration into plant host. Here the combination of cellulase and pectinase was ascertained on the pathogenicity of F. compactum (1.4 × 106 propagules ml−1) on broomrape tubercles. F. compactum alone infected all the inoculated tubercles but did not kill any significant number. Infested tomato roots that were inoculated with mycelia plus pectinase (20 U ml−1) had over 50% tubercles dead one week after treatment. Those inoculated with mycelia plus cellulase (20 U ml−1) had above 60% mortality. Mixtures of mycelial plus the two enzymes (10 U ml−1 of each enzyme) showed synergy. The activity catalyzed by an enzyme is a measure of the amount of enzyme present. It was shown that, in a 1 mg (10 U mg−1) cellulase used, 0.055 mg pectinase (1.1 U mg−1) is present. This explains why mycelial plus cellulase mix contends with mycelial plus the two enzymes.
Animal Models of Colitis-Associated Carcinogenesis

Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders that affect individuals throughout life. Although the etiology and pathogenesis of IBD are largely unknown, studies with animal models of colitis indicate that dysregulation of host/microbial interactions are requisite for the development of IBD. Patients with long-standing IBD have an increased risk for developing colitis-associated cancer (CAC), especially 10 years after the initial diagnosis of colitis, although the absolute number of CAC cases is relatively small. The cancer risk seems to be not directly related to disease activity, but is related to disease duration/extent, complication of primary sclerosing cholangitis, and family history of colon cancer. In particular, high levels and continuous production of inflammatory mediators, including cytokines and chemokines, by colonic epithelial cells (CECs) and immune cells in lamina propria may be strongly associated with the pathogenesis of CAC. In this article, we have summarized animal models of CAC and have reviewed the cellular and molecular mechanisms underlining the development of carcinogenic changes in CECs secondary to the chronic inflammatory conditions in the intestine. It may provide us some clues in developing a new class of therapeutic agents for the treatment of IBD and CAC in the near future.
Social Situation Observatory Demography Monitor 2008: demographic trends, socioeconomic impacts and policy implications in the European Union: final report

The Demography Monitor 2008 gives a concise overview of current demographic trends and related developments in education, the labour market and retirement for the European Union and some other countries. Changes in fertility, family formation, migration and mortality are documented as well as trends in population growth and population ageing. Also the links of demographic developments with education, labour and retirement are described. The Demography Monitor 2008 was produced by the Demography Network of the Social Situation Observatory of the European Commission which is led by the Netherlands Interdisciplinary Demographic Institute (NIDI).
Effects of Cortisol on the Intestinal Mucosal Immune Response during Cohabitant Challenge with IPNV in Atlantic Salmon (Salmo salar)

Infectious pancreatic necrosis virus (IPNV) causes high incidence of disease in salmonids during the first period after SW transfer. During this period as well as during periods of stress, cortisol levels increase and indications of a relationship between IPNV susceptibility and cortisol have been suggested. The intestine is an entry route and a target tissue for IPNV displaying severe enteritis and sloughing of the mucosa in infected fish. The mechanisms behind effects of the virus on the intestinal tissue and the impact of cortisol on the effect remain unclear. In the present study, Atlantic salmon post smolts treated with or without slow release cortisol implants were subjected to a cohabitant IPNV challenge. Analysis of genes and proteins related to the innate and acquired immune responses against virus was performed 6 days post-challenge using qPCR and immunohistochemistry. An increased mRNA expression of anti-viral cytokine interferon type I was observed in the proximal intestine and head kidney as a response to the viral challenge and this effect was suppressed by cortisol. No effect was seen in the distal intestine. T-cell marker CD3 as well as MHC-I in both intestinal regions and in the head kidney was down regulated at the mRNA level. Number of CD8α lymphocytes decreased in the proximal intestine in response to cortisol. On the other hand, mRNA expression of Mx and IL-1β increased in the proximal intestine and head kidney in IPNV challenged fish in the presence of cortisol suggesting that the immune activation shifts in timing and response pathway during simulated stress. The present study clearly demonstrates that IPNV infection results in a differentiated epithelial immune response in the different intestinal regions of the Atlantic salmon. It also reveals that the epithelial immune response differs from the systemic, but that both are modulated by the stress hormone cortisol.
Human airway smooth muscle cells secrete vascular endothelial growth factor: up‐regulation by bradykinin via a protein kinase C and prostanoid‐dependent mechanism

Bronchial vascular remodeling is an important feature of the pathology of chronic asthma, but the responsible mechanisms and main sources of an‐giogenic factors are unclear. Here we report that human airway smooth muscle cells express vascular endo‐thelial growth factor (VEGF)121,165,189,206 splice variants and secrete VEGF protein constitutively. VEGF protein secretion was increased by the proinflammatory asthma mediator bradykinin through post‐transcrip‐tional mechanisms. Bradykinin‐induced VEGF secretion was dependent on the B2 bradykinin receptor activation of protein kinase C and generation of endogenous prostanoids. This is the first report that bradykinin can increase VEGF secretion in any biological system and the first to show that airway smooth muscle cells produce VEGF. Our results suggest a novel role for human airway smooth muscle in contributing to bronchial mucosal angiogenesis in chronic asthma by secretion of VEGF and suggest a wider role for mesen‐chymal cell products in mediating angiogenesis in inflammatory and allergic diseases. —Knox, A. J., Corbett, L. , Stocks, J., Holland, E. , Zhu, Y. M. , Pang, L. Human airway smooth muscle cells secrete vascular endothelial growth factor: up‐regulation by bradykinin via a protein kinase C and prostanoid‐dependent mechanism. FASEB J. 15, 2480–2488 (2001)
The role of estrogen in turtle sex determination and the effect of PCBs.

In the current model of vertebrate sex determination and sexual differentiation, gonadal sex is fixed at fertilization by specific chromosomes, a process known as genotypic sex determination (GSD). Only after the gonad is formed do hormones begin to exert an influence that modifies specific structures that eventually will differ the sexes. Many egg-laying reptiles do not exhibit GSD but rather depend on the temperature of the incubating egg to determine the gonadal sex of the offspring, a process termed temperature-dependent sex determination (TSD). Research on TSD indicates that sex determination in these species is fundamentally different in at least one way. Gonadal sex is not irrevocably set by the genetic composition inherited at fertilization but depends ultimately on which genes encoding for steroidogenic enzymes and hormone receptors are activated during the midtrimester of embryonic development by temperature. Incubation temperature modifies the activity as well as the temporal and spatial sequence of enzymes and hormone receptors such that sex-specific hormone milieus, created in the urogenital system of the developing embryo, determine gonad type. Estrogen is the physiologic equivalent of incubation temperature and the proximate cue that initiates female sex determination. There is increasing evidence that some polychlorinated biphenyl (PCB) compounds are capable of disrupting reproductive and endocrine function in fish, birds, and mammals, including humans. Reproductive disorders resulting from exposure to these xenobiotic compounds may include reductions in fertility, hatch rate in fish and birds, and viability of offspring, as well as alterations in hormone levels or adult sexual behaviors, all of which have further implications, particularly in wildlife population dynamics. Research on the mechanism through which these compounds may be acting to alter reproductive function indicates estrogenic activity, by which the compounds may be altering sexual differentiation. In TSD turtles, the estrogenic effect of some PCBs reverses gonadal sex in individuals incubating at an otherwise male-producing temperature. Furthermore, certain PCBs are synergistic in their effect at very low concentrations. ImagesFigure 4. AFigure 4. BFigure 4. CFigure 4. D
Deflationary Shocks and De-Anchoring of Inflation Expectations

A prolonged period of low inflation, particularly in a situation of monetary policy rates near the zero lower bound, can heighten the risk of inflation expectations de-anchoring from the central bank objective. The purpose of this paper is to assess the effects of a sequence of deflationary shocks, such as those that hit the euro area in 2013-14, on expected/realized inflation and output. To do so we consider a simple New Keynesian model where agents, rather than being endowed with rational expectations, have incomplete information about the working of the economy and form expectations through an adaptive learning process (in the sense that they behave like econometricians, using regressions to anticipate the future value of the variables of interest). The model is simulated with euro area data over the period 2014-16 under the assumption both of rational expectations and of learning. The main findings are the followings: (i) under learning, price dynamics in 2015-16 is on average 0.6 percentage points lower than in the case of fully rational agents, as inflation expectations are strongly affected by the repeated deflationary shocks; (ii) the learning process implies a (data-driven) de-anchoring of inflation expectations from the central bank target, which would be perceived by economic agents to fall to 0.8% at the end of 2016; (iii) output expectations would also be lower in the case of learning, resulting in a slower recovery of economic activity.
Agile Collaborative Research: Action Principles for Industry-Academia Collaboration

Both the software industry and academia promote collaboration to solve challenges together that neither can solve alone. Collaboration brings opportunities to understand and improve in ways not possible when working apart, but it succeeds only if both parties are contributing. A collaboration model developed from eight years' experience setting up and managing a research center explicitly focused on industry needs is based on five success factors enabling research results (need orientation, industry goal alignment, deployment impact, industry benefit, and innovativeness), five success factors enabling research activities (management engagement, network access, collaborator match, communication ability, and continuity), and 10 action principles for industry-academia collaboration management.
Sharing responsibility for refugee protection in Europe: Dublin reconsidered

This report highlights the inherent limitations and injustices of the Dublin system, which transfers asylum seekers between EU Member States, and outlines alternative proposals for a fairer and more efficient system. ECRE strongly believes that the Dublin Regulation does not promote harmonisation of EU asylum systems, seriously impedes integration, and sows dissension among Member States. Instead of pretending it can be made to work, the Stockholm Programme should repeal the Dublin Regulation and devise an efficient responsibility-sharing regime that improves solidarity among Member States, and promotes the integration of people who seek, and deserve, international protection.
Assisted dynamics of multi--scalar field cosmologies

We examine the dynamics of an arbitrary number of scalar fields interacting via a series of exponential potentials. In many cases, redefining the fields reduces the system to a single field with a single exponential potential, independent of the background spacetime. We show that this solution is the late–time attractor for an arbitrary number of scalar fields interacting via two exponential potentials. We apply this analysis to a reduced action resulting from a generalized compactification of higher–dimensional massless fields. PACS numbers: 98.80. Cq Typeset using REVTEX 1