Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessment of Toxoplasma Seropositivity in Children Suffering from Anxiety Disorders

Objective This study aimed to assess the seroprevalence of Toxoplasma gondii in children with anxiety disorders. Materials & Methods This cross-sectional study was conducted between Sep 2012 and May 2013 in Pediatrics Clinic of Baqiyatallah Hospital, Tehran, Iran. Children were assessed clinically. Diagnosis of patients with anxiety disorders was based on DSM-4 system, performed by child psychiatrist. Then their anti-Toxoplasma antibodies were measured. A questionnaire was verbally administered to all individuals’ parents including demographic information and questions about life style, family history, medical history, economic situation, residence, nutritional patterns and contact with animals. Results Ninety-six male and female cases with a mean age of 8.56±2.5 and 8.42±1.9 yr underwent analysis. Anti- T. gondii IgG antibody was found in one case of each group. There was no significant difference between case and control groups for serum Toxoplasma IgG antibody (P=0.14). No case individuals had Anti- T. gondii IgM antibody, while it was found in one control individual. No significant difference was seen between case and control groups for Toxoplasma IgM antibody (P=0.27). Conclusion Toxoplasmosis has no direct effect on the incidence of anxiety disorders. More studies are needed with a larger volume of individuals in future.
Continuity and change: an evaluation of the democracy-foreign policy nexus in post-apartheid South Africa

If foreign policy is viewed as an "intermestic" arena where the external meets the internal, then it becomes possible to see how internal domestic factors drive foreign policy making. In this context the democracy-foreign policy nexus and the role of governmental and non-governmental foreign policy actors help to reconcile ideals and interests and put foreign policy contradictions into perspective. The desirability of democratic participation in foreign policy is taken as a given, but agency has to go beyond representation to include issues of participation and political dialogue. The focus of this article is the democratic deficit of the Mbeki foreign policy (1999-2008), with some reference to the Zuma administration. The way in which foreign policy was personalised under the presidency of Mbeki was instrumental in closing the space for meaningful participation in the foreign policy processes. The article concludes that democratic foreign policy making is impeded by an overall deterioration in the quality of democracy in post-apartheid South Africa. It further contends that there is more continuity than change across the Mbeki and Zuma administrations' policy orientations (both domestic and foreign) and warns that the challenges which Mbeki faced in terms of democratic consolidation may be exacerbated in the Zuma period if certain demons are not tackled head on.
Face tracking: State of the art

Face detection and tracking is challenging problem in image processing and computer vision. In the last few years, it has received a great attention because of its many applications based on various methods in different fields such as law enforcement, security and so on. Face detection and tracking are the two processes done by using various approaches. It is applied mainly in surveillance. The main purpose of these processes are detect and track the face even in poor viewing conditions in surveillance application. This paper describes various techniques used for face tracking, their advantages and their disadvantages, and we discuss the comparison between these techniques.
Innovative Concept for sustainable treatment of municipal wastewater

Current systems for centralised treatment of municipal wastewater are technically highly efficient and cost effective. However, from an environmental point of view these systems are not very sustainable. An innovative concept for a more sustainable treatment of municipals wastewater is proposed. The system is primarily based on the application of UF/MF and RO membranes and anaerobic digestion. A preliminary study towards the feasibility of this innovative concept leads to the conclusion that it has the potential to recover nutrients and effluent for reuse, to produce substantially higher amounts of biogas than conventional systems, and requires a very small footprint. The costs are higher but probably acceptable. Further research is necessary to elaborate and develop this system for practical application. Involvement of stakeholders is expected to be necessary for the further development of this system.
Okadaic Acid: More than a Diarrheic Toxin

Okadaic acid (OA) is one of the most frequent and worldwide distributed marine toxins. It is easily accumulated by shellfish, mainly bivalve mollusks and fish, and, subsequently, can be consumed by humans causing alimentary intoxications. OA is the main representative diarrheic shellfish poisoning (DSP) toxin and its ingestion induces gastrointestinal symptoms, although it is not considered lethal. At the molecular level, OA is a specific inhibitor of several types of serine/threonine protein phosphatases and a tumor promoter in animal carcinogenesis experiments. In the last few decades, the potential toxic effects of OA, beyond its role as a DSP toxin, have been investigated in a number of studies. Alterations in DNA and cellular components, as well as effects on immune and nervous system, and even on embryonic development, have been increasingly reported. In this manuscript, results from all these studies are compiled and reviewed to clarify the role of this toxin not only as a DSP inductor but also as cause of alterations at the cellular and molecular levels, and to highlight the relevance of biomonitoring its effects on human health. Despite further investigations are required to elucidate OA mechanisms of action, toxicokinetics, and harmful effects, there are enough evidences illustrating its toxicity, not related to DSP induction, and, consequently, supporting a revision of the current regulation on OA levels in food.
Chronic Respiratory Symptoms with Normal Spirometry. A Reliable Clinical Entity?

Chronic Respiratory Symptoms with Normal Spirometry A Reliable Clinical Entity? Roberto Rodriguez-Roisin, MeiLan K. Han, Jørgen Vestbo, Jadwiga A. Wedzicha, Prescott G. Woodruff, and Fernando J. Martinez Universitat de Barcelona, Institut Clinic Respiratori, Hospital Clı́nic–Institut d’Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Division of Pulmonary & Critical Care Medicine, University of Michigan, Ann Arbor, Michigan; Centre for Respiratory Medicine and Allergy, University of Manchester, Manchester, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom; Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine and Cardiovascular Research Institute, University of California San Francisco, San Francisco, California; and Weill Cornell Medical College, New York, New York
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

Autotaxin (ATX) is a tumor cell motility–stimulating factor, originally isolated from melanoma cell supernatants. ATX had been proposed to mediate its effects through 5′-nucleotide pyrophosphatase and phosphodiesterase activities. However, the ATX substrate mediating the increase in cellular motility remains to be identified. Here, we demonstrated that lysophospholipase D (lysoPLD) purified from fetal bovine serum, which catalyzes the production of the bioactive phospholipid mediator, lysophosphatidic acid (LPA), from lysophosphatidylcholine (LPC), is identical to ATX. The Km value of ATX for LPC was 25-fold lower than that for the synthetic nucleoside substrate, p-nitrophenyl-tri-monophosphate. LPA mediates multiple biological functions including cytoskeletal reorganization, chemotaxis, and cell growth through activation of specific G protein–coupled receptors. Recombinant ATX, particularly in the presence of LPC, dramatically increased chemotaxis and proliferation of multiple different cell lines. Moreover, we demonstrate that several cancer cell lines release significant amounts of LPC, a substrate for ATX, into the culture medium. The demonstration that ATX and lysoPLD are identical suggests that autocrine or paracrine production of LPA contributes to tumor cell motility, survival, and proliferation. It also provides potential novel targets for therapy of pathophysiological states including cancer.
High-level connectionist models

A workshop on high-level connectionist models was held in Las Cruces, New Mexico, on 9-11 April 1988 with support from the Association for the Advancement of Artificial Intelligence and the Office of Naval Research. John Barnden and Jordan Pollack organized and hosted the workshop and will edit a book containing the proceedings and commentary. The book will be published by Ablex as the first volume in a series entitled Advances in Connectionist and Neural Computation Theory.
Information in the brain : a molecular perspective

Drawing on his considerable experience as a neuroscientist and clinical neurologist, Ira Black systematically disentangles the labyrinth of brain and mind in a new concept of mind that relates environment, brain genes, molecular symbols, behavior and mentation. He describes the unity of brain, mind, and experience with singular clarity, showing how mental function, brain function, and biologic information are now comprehensible in molecular terms.Writing in a clear and often conversational style, Black defines the molecular biology and biochemistry of information processing in the nervous system and describes in detail the environmental regulation of brain genes that encode molecular symbols. His coherent vision of the vast biological information system provides insight into questions of how the mind is related to the brain, what constitutes the substance of thought or the physical bases of memory, how experience changes mind function or environmental information is converted into neural language, and what biochemical abnormalities lead to Alzheimer's disease, Parkinson's disease, and schizophrenia.Information in the Brain identifies common concepts and themes in widely diverse fields, revealing the extraordinary scope of modern neuroscience, and makes central issues in the brain sciences accessible to a variety of readers. Black's description of the critical role that gene structure plays in ongoing brain and mind function will appeal to molecular biologists. Protein chemists will understand how molecular structure is translated into behavior and mentation. Neuroscientists will gain an explicit understanding of the central questions in psychology. In turn, psychologists will find new ideas concerning cellular and molecular bases of brain function and clinical neurologists and psychiatrists will discover new formulations of the pathogenesis of disease at genomic, molecular, and systems levels.Ira B. Black is Professor and Chairman, Department of Neuroscience and Cell Biology, the Robert Wood Johnson Medical School/UMDNJ.
Non-steroidal anti-inflammatory drugs in sports medicine: guidelines for practical but sensible use

Introduction: Non-steroidal anti-inflammatory drugs (NSAID) are commonly used in sports medicine. NSAID have known anti-inflammatory, analgesic, antipyretic and antithrombotic effects, although their in-vivo effects in treating musculoskeletal injuries in humans remain largely unknown. NSAID analgesic action is not significantly greater than paracetamol for musculoskeletal injury but they have a higher risk profile, with side-effects including asthma exacerbation, gastrointestinal and renal side-effects, hypertension and other cardiovascular diseases. Discussion: The authors recommend an approach to NSAID use in sports medicine whereby simple analgesia is preferentially used when analgesia is the primary desired outcome. However, based both on the current pathophysiological understanding of most injury presentations and the frequency that inflammation may actually be a component of the injury complex, it is premature to suppose that NSAID are not useful to the physician managing sports injuries. The prescribing of NSAID should be cautious and both situation and pathology specific. Both dose and duration minimisation should be prioritised and combined with simple principles of protection, rest, ice, compression, elevation (PRICE), which should allow NSAID-sparing. NSAID use should always be coupled with appropriate physical rehabilitation. Conclusion: NSAID are probably most useful for treating nerve and soft-tissue impingements, inflammatory arthropathies and tenosynovitis. They are not generally indicated for isolated chronic tendinopathy, or for fractures. The use of NSAID in treating muscle injury is controversial. Conditions in which NSAID use requires more careful assessment include ligament injury, joint injury, osteoarthritis, haematoma and postoperatively.
Age‐related changes in the elastic properties and thickness of human facial skin

Using recently designed, commercially available, non‐invasive instruments, we measured the thickness and elasticity of the skin of the face and ventral forearm in 170 women, and evaluated the effects of age and exposure to sunlight. Skin thickness decreased with age in ventral forearm skin, which has limited exposure to sunlight, but increased significantly in the skin of the forehead, corners of the eyes, and cheeks, which are markedly exposed to sunlight. Skin elasticity (Ur/Uf) decreased with age on both the face and forearm. The ratio of viscosity element to elasticity element (Uv/Ue) increased with age at all sites. However, delayed distension (Uv), immediate retraction (Ur), final distension (Uf), and immediate distention (Ue), as individual elements, decreased on the face and increased on the forearm with age. This tendency was more marked after correction for skin thickness. These results suggested the specificity of skin thickness and elasticity in the facial skin. Analysis using a four‐element model showed no changes in the elasticity coefficient of Maxwell element on the forearm, but an increase on the face. This indicates quantitative or qualitative changes in elastic fibres in facial skin. Thus, sunlight appears to have a considerable effect on the thickness and physical properties of facial skin.
Biological Therapy in Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a prototypic inflammatory autoimmune disorder characterized by multisystem involvement and fluctuating disease activity. Symptoms range from rather mild manifestations such as rash or arthritis to life-threatening end-organ manifestations. Despite new and improved therapy having positively impacted the prognosis of SLE, a subgroup of patients do not respond to conventional therapy. Moreover, the risk of fatal outcomes and the damaging side effects of immunosuppressive therapies in SLE call for an improvement in the current therapeutic management. New therapeutic approaches are focused on B-cell targets, T-cell downregulation and costimulatory blockade, cytokine inhibition, and the modulation of complement. Several biological agents have been developed, but this encouraging news is associated with several disappointments in trials and provide a timely moment to reflect on biologic therapy in SLE.
Deep vein thrombosis and pulmonary embolism in the general population. 'The Study of Men Born in 1913'.

BACKGROUND Deep vein thrombosis (DVT) and pulmonary embolism (PE) are common public health problems. Still, little is known about the epidemiology and the natural history of venous thromboembolism. METHODS In the Study of Men Born in 1913, 855 men were followed up prospectively from the age of 50 years to the age of 80 years. Several cross-sectional samples, also of men born in 1913, were studied at the ages of 50, 54, 60, 67, 75, and 80 years. Objective methods were used to ascertain a diagnosis of DVT or PE, and all were confirmed by hospital records or autopsy reports. The follow-up rate in the longitudinal study was 98.2%. RESULTS In the longitudinal study, the incidence of DVT was 182 per 100,000 observation-years. Corresponding incidence rates were 98 for nonfatal PE, 107 for fatal PE, and 387 for all thromboembolic events. The cumulative probability for a venous thromboembolic event at different ages was estimated to be 0.5% by the age of 50 years and 10.7% by the age of 80 years. In the cross-sectional studies, a history of confirmed venous thromboembolism was found in 0.5% of the men at age 50 years, 0.9% at age 54 years, 1.3% at age 60 years, 2.0% at age 67 years, 4.5% at age 75 years, and 3.8% at age 80 years. CONCLUSIONS The results indicate a high incidence of DVT and PE in the general population. The incidence of thromboembolic events increases with age. The rate of fatal PE seems to be higher than estimated before, and PE constitutes almost 5% of all deaths during follow-up.
Biomechanical comparison of pin and nitinol bone staple fixation to pin and tension band wire fixation for the stabilization of canine olecranon osteotomies

Summary Objective: To compare the initial biomechanical properties of olecranon osteotomies stabilized with intramedullary pins and a Nitinol bone staple to osteotomies stabilized with pin and tension band wire fixation. Study design: Ex vivo mechanical evaluation on cadaveric bones. Material and methods: Ten pairs of cadaveric forelimbs from skeletally mature Greyhounds with an olecranon osteotomy stabilized with either a pin and Nitinol bone staple or a pin and tension band wire. A single load to failure was applied to each specimen through the triceps tendon. Biomechanical properties were compared based on stiffness, yield load, and maximum load to failure and load at 2 mm of axial displacement. Results: Specimens stabilized with the bone staple were biomechanically superior in all the variables tested. There was significantly greater stiffness (118.0 ± 25.9 N/mm versus 70.1 ± 40.4 N/mm; p = 0.005), yield load (319.0 ± 99.8 N versus 238.0 ± 42.5 N; p = 0.03), maximum load sustained (385.0 ± 99.2 N versus 287.0 ± 37.4 N; p = 0.009), and load at 2 mm of axial displacement (218.0 ± 51.5 N versus 138.0 ± 48.7 N; p = 0.002) in specimens stabilized with pins and a Nitinol bone staple than specimens stabilized with pin and tension band wire fixation. Clinical significance: The pin and Nitinol bone staple construct provides a biomechanically superior alternative to pin and tension band wire fixation for stabilization of olecranon osteotomies, and its use warrants further clinical investigation. Supplementary material for this article is available at https://doi.org/10.3415/VCOT-17-02-0025
Development of a German Implicit Measure of Religiosity

This study addressed the lack of implicit measures of religiosity in German research by developing a German Single Category Implicit Association Test (SC-IAT) for measuring the associative religious self-concept. The SC-IAT was applied to a sample consisting of 389 German students with different subjects of study and internally consistent (r = .72). To estimate the psychometric criteria of construct validity, SC-IAT scores were correlated to the Centrality of Religiosity Scale (CRS), whose construct psychological approach can be theoretically linked to the concept of associative representations in the research on IATs. Corresponding to the average relationship between implicit and explicit measures in literature, the correlation was moderately (r = .33). Group comparisons relating to religious affiliation and subject of study provided initial evidence for criterion validity. There were complications with the attribute category “non-religious,” especially by participants without a religious affiliation, however, the SC-IAT could also provide a method to investigate this issue.
Deadline-modification-SCAN with maximum-scannable-groups for multimedia real-time disk scheduling

Real-time disk scheduling is important to multimedia systems support for digital audio and video. In these years, various approaches are presented to use the seek-optimizing scheme to improve the disk throughput of a real-time guaranteed schedule. However, as these conventional approaches apply SCAN only to the requests with the same deadline or within the same constant-sized group, their improvements are limited. In this paper, we introduce the DM-SCAN (deadline-modification-SCAN) algorithm with an idea of MSG (maximum-scannable-group). The proposed DM-SCAN method can apply SCAN to MSG iteratively by modifying request deadlines. We have implemented the DM-SCAN algorithm on UnixWare 2.01. Experiments show that DM-SCAN is significantly better than that of the best-known SCAN-EDF method in both the obtained disk throughput and the number of supported disk requests.
An integrated navigation algorithm for AUV based on Pseudo-range measurements and error estimation

The Long Baseline (LBL) system is very important to precisely localize autonomous underwater vehicles (AUVs) close to the sea bottom in deep water. But the calibration error of the LBL beacons and the pseudo-range measurement caused by the motivation of the AUV, both them dilute the accuracy of LBL acoustic position. This paper proposes a quantitative description of the calibration error of beacons and pseudo-range how they reduce the LBL acoustic position precise. And then this paper proposes an integrated navigation algorithm for AUV, which integrates inertial navigation and LBL acoustic location to reduce the influence of the calibration errors of beacons and pseudo-range by online calibrating the beacon location errors and compensating the motivation of AUV to pseudo-range model. We name this algorithm as Pseudo-range and SLAM of beacons EKF (P-SLAM EKF). Through the sea trials of Qianlong-1, our algorithm proves very reliable and effective.
Pattern of 25-hydroxy vitamin D response at short (2 month) and long (1 year) interval after 8 weeks of oral supplementation with cholecalciferol in Asian Indians with chronic hypovitaminosis D

Hypovitaminosis D is common in Asian Indians. Physicians often prescribe 1500 μg (60 000 IU) cholecalciferol per week for 8 weeks for vitamin D deficiency in India. Its efficacy to increase serum 25-hydroxy vitamin D (25(OH)D) over short (2 months) and long (1 year) term is not known. We supplemented a group of twenty-eight apparently healthy Asian Indians detected to have low serum 25(OH)D (mean 13·5 (sd 3·0) nmol/l) on screening during January–March 2005. Serum parathyroid hormone (PTH) level was supranormal in 30 % of them. Oral supplementation included 1500 μg cholecalciferol per week and 1g elemental Ca daily for 8 weeks. Serum 25(OH)D, total Ca, inorganic P and intact (i) PTH were reassessed in twenty-three subjects (twelve females and eleven males) who had follow up at both 8 weeks and 1 year. At 8 weeks the mean 25(OH)D levels increased to 82·4 (sd 20·7) nmol/l and serum PTH normalized in all. Twenty-two of the twenty-three subjects had 25(OH)D levels>49·9 nmol/l. At 1 year, though the mean 25(OH)D level of 24·7 (sd 10·9) nmol/l was significantly higher than the baseline, all subjects were 25(OH)D deficient. Five subjects with supranormal iPTH at baseline showed recurrence of biochemical hyperparathyroidism. Thus, with 8 weeks of cholecalciferol supplementation in Asian Indians with chronic hypovitaminosis D, mean serum 25(OH)D levels would be normalized and serum PTH value would be reduced to half. However, such quick supplementation would not maintain their 25(OH)D levels in the sufficient range for 1 year. For sustained improvement in 25(OH)D levels vitamin D supplementation has to be ongoing after the initial cholecalciferol loading.