Miracle-dz/UniFAR-FTUs huggingface dataset:
Techniques d'interaction avec un espace de données temporelles. (Interaction techniques for temporal data)

Les donnees temporelles sont frequemment manipulees dans plusieurs domaines d'application (bancaire, clinique, geographique, etc.). Malgre la diversite des techniques proposees pour visualiser ce type de donnees, nous constatons un manque d'approches et de methodes de conception. Dans cette these, nous proposons une approche de conception de techniques de visualisation et plus generalement d'interaction avec des espaces de donnees temporelles. Pour garantir l'utilisabilite de ces techniques, nous proposons de prendre en compte les caracteristiques des donnees manipulees et les tâches utilisateur, nous situant ainsi a la jonction de deux domaines de l'informatique : les Bases de Donnees et les Interfaces Homme-Machine. Ce travail contribue donc a la conception de systemes interactifs pour l'analyse visuelle de donnees temporelles. Dans ce contexte, nous proposons une taxonomie qui organise les travaux existants de visualisation de donnees temporelles selon leur processus de visualisation. Cette taxonomie est construite a partir du processus de visualisation propose par Chi. En collaboration avec des utilisateurs geographes, nous avons identifie une liste de tâches utilisateur pertinentes pour la manipulation de donnees temporelles. A partir de cette liste, nous avons concu et implemente cinq techniques d'interaction adaptees aux tâches identifiees. Nous avons integre ces techniques pour developper INVEST (Interactive Visualization and Explorative System of Temporal data) qui est une plate-forme multi-techniques pour l'analyse visuelle de donnees temporelles. Chaque technique de visualisation est une vue du meme espace de donnees. INVEST inclut un moteur de selection de techniques de visualisation en fonction des tâches utilisateur specifiees.
Dynamic simulation of HVDC interconnection in large power system

This paper develops a controller for a line commutated converter HVDC in order to improve the transient stability of the power system. This controller is based on the integration of a frequency modulation to the HVDC control scheme. The HVDC model based on CIGRE benchmark model is used for dynamic simulation to investigate the system's operation when subjected by faults and large disturbances. Simulations are implemented on the simplified Southern Eastern (SE) Australian power system using the Power Factory software package.
Virtual reality, robot, and object touch: Blended reality sensorimotor training experience

Loss of body sensations often accompanies injuries to the central or peripheral nervous system and can lead to disintegration of body schema resulting in altered sensory dependent motor skills. Localizing external objects within peripersonal space plays an important role in the strategies of accurate human movement, towards targets and for obstacle avoidance. In our system, practicing viewing and finger-tip contact with real objects is enabled using Blended Reality: Virtual Reality, Robot Assistance, and Real Object Touch. Arm Location exercises accompany multi-sensory experience in the blended reality. Adding vision and touch, salient properties of three dimensional real objects, to the technology assisted training environment increases the number and realistic qualities of sensory modalities for integration to bolster performance of the trainee. A number of exercises have been developed and are being investigated to understand contributions of the multi-sensory experiences upon performance, and to identify appropriate protocols for therapy.
Comparing Hatha yoga with dynamic group psychotherapy for enhancing methadone maintenance treatment: a randomized clinical trial.

BACKGROUND As more methadone treatment programs are funded in an attempt to curb substance abuse and HIV infection among i.v. drug users, more cost effective treatment approaches are being sought. OBJECTIVES To investigate whether clients in outpatient methadone maintenance treatment who practice weekly Hatha yoga in a group setting experience more favorable treatment outcomes than those who receive conventional group psychodynamic therapy. METHODS After a 5-day assessment period, 61 patients were randomly assigned to methadone maintenance enhanced by traditional group psychotherapy (ie, conventional methadone treatment) or an alternative Hatha yoga therapy (ie, alternative methadone treatment). Patients were followed for 6 months and evaluated on a variety of psychological, sociological, and biological measures. The revised Symptom Check List provided the primary psychological measures; the Addiction Severity Index provided various indices of addictive behaviors. RESULTS The evidence revealed that there were no meaningful differences between traditional psychodynamic group therapy and Hatha yoga presented in a group setting. Both treatments contributed to a treatment regimen that significantly reduced drug use and criminal activities. Psychopathology at admission was significantly related to program participation regardless of treatment group. DISCUSSION In addition to examining the characteristics of patients who present for treatment, this study identifies unexpected staff issues that complicate the integration of alternative and traditional treatment strategies. CONCLUSION Alternative methadone treatment is not more effective than conventional methadone treatment, as originally hypothesized. However, some patients may benefit more from alternative methadone treatment than conventional methadone treatment. Additional research is necessary to determine characteristics that identify patients who might benefit from alternative methadone treatment.
Development of a brain computer interface for delivery of non-invasive brain stimulation during visuomotor task performance - a method study

The ability to walk is important for independent performance of activities of daily living and therefore determines quality of life. Consequently impairment of walking has been mentioned most frequently as the most important disabling symptom in community-dwelling stroke survivors. Walking activity requires a complex pattern of neural commands. Parts of the central nervous system motor network are the primary motor cortex, premotor areas, parietal cortex, basal ganglia, thalamus, and cerebellum. Innovative methodologies leveraging brain computer interfaces (BCI) for stroke neurorehabilitation are urgently required to reduce long-term walking disability. Neuroplastic changes, which are strongly related to relearning of disabled functions in rehabilitation, may be facilitated during BCI therapy with non-invasive multi-level electrotherapy such as neuromuscular electrical stimulation (NMES) and noninvasive brain stimulation (NIBS). We propose a multi-level electrotherapy paradigm towards motor rehabilitation in virtual reality that postulates that while the brain acts as a controller in a closed-loop BCI to drive NMES, the state of brain can be can be altered towards improvement of visuomotor task performance with NIBS. Therefore, this paper presents the development of a BCI for delivery of NIBS during a lower-limb visuomotor task. Some preliminary results from healthy subjects are presented additionally.
Receptor‐mediated targeting of gene delivery vectors: Insights from molecular mechanisms for improved vehicle design

One way to deliver transgenes to cells in a selective manner is to target the delivery vehicles, or vectors, to specific cell‐surface receptors as a first step toward ulimate transport of the gene to the nucleus for expression. While selective delivery, although often to undesired cell types, occurs naturally for some viral vectors and can be achieved for nonviral vehicles, current understanding and control of the delivery mechanism is inadequate for many therapeutic applications. The complicated nature of receptor‐mediated transgene uptake and transport requires improved analysis to more effectively evaluate delivery vehicles. As receptor‐mediated pathways for gene delivery typically involve vector binding, internalization, subcellular trafficking, vesicular escape, nuclear translocation, and unpackaging for transcription, each of these processes offer mechanisms that can be exploited to enhance targeted gene delivery via properly designed vehicles.
Magnetocrystalline anisotropy of magnetite

The spin reorientation temperature TSR of stoichiometric Fe3O4, as well as of magnetite with a small number of vacancies and magnetite containing a low concentration of Ti, Zn, Al and Ga was measured on single-crystal samples using the ac susceptibility. In the same experiment the temperature TV of the Verwey transition was also found. The results show that a correlation between TSR and TV exists. The electronic structure of the compounds studied was determined using the density-functional-based GGA + U method. For stoichiometric magnetite the first and second cubic anisotropy constants were calculated, while for magnetite with defects the distribution of electron density using the ‘atoms in molecules’ approach was determined. Based on a combination of experimental results with the electronic structure calculations an explanation of the temperature dependence of the magnetocrystalline anisotropy of magnetite is suggested.
EAE Tolerance Induction with Hsp70-Peptide Complexes Depends on H60 and NKG2D Activity1

Inflammation leads to induction of tissue stress conditions that might contribute to the generation of mechanisms limiting ongoing immune responses. We have shown previously that peptides derived from brain tissue of mice with experimental autoimmune encephalomyelitis (EAE) complexed with the chaperone heat shock protein 70 (Hsp70-pc) induce an NK-cell-dependent tolerance for subsequent EAE sensitization. We now present data that showed that the MHC class I-related glycoprotein H60 determines Hsp70-pc-induced EAE inhibition. Hsp70-pc led to significant and selective up-regulation of H60 expression in SJL/J mice, and Ab-blocking of H60 expression led to loss of EAE tolerance. Similarly, blocking of the NK cell receptor for H60, NKG2D, also reversed the Hsp70-pc-induced EAE inhibition. In contrast, in C57BL/6 mice H60 was not expressed, and Hsp70-pc-induced tolerance was not detected. The NK cell mediated Hsp70-pc-induced tolerance to EAE was dependent on modulation of dendritic cells function leading to diminished T cell reactivity to PLP. As, no increase of H60 expression on T cells from EAE mice immunized with PLP was detected, and no enhanced loss of CD3+H60+over CD3+H60− cells in Hsp70-pc-induced EAE tolerance was found direct killing of H60+ PLP-reactive cells seems not to be involved in the Hsp70-pc-induced tolerance induction. We have provided evidence that Hsp70-pc-induced tolerance for EAE, mediated by NK cells, involves induction of H60 ligand and its interaction with NKG2D receptor. NK cells tolerization of EAE depends on altered dendritic cells activity leading to enhanced death of Ag reactive cells.
The right half of the Escherichia coli replication origin is not essential for viability, but facilitates multi‐forked replication

Replication initiation is a key event in the cell cycle of all organisms and oriC, the replication origin in Escherichia coli, serves as the prototypical model for this process. The minimal sequence required for oriC function was originally determined entirely from plasmid studies using cloned origin fragments, which have previously been shown to differ dramatically in sequence requirement from the chromosome. Using an in vivo recombineering strategy to exchange wt oriCs for mutated ones regardless of whether they are functional origins or not, we have determined the minimal origin sequence that will support chromosome replication. Nearly the entire right half of oriC could be deleted without loss of origin function, demanding a reassessment of existing models for initiation. Cells carrying the new DnaA box‐depleted 163 bp minimal oriC exhibited little or no loss of fitness under slow‐growth conditions, but were sensitive to rich medium, suggesting that the dense packing of initiator binding sites that is a hallmark of prokaryotic origins, has likely evolved to support the increased demands of multi‐forked replication.
ANALYSIS OF RELATIVE RETURN BEHAVIOUR OF BORSA ISTANBUL REIT AND BORSA ISTANBUL 100 INDEX

This study examines the return and volatility behaviour of Borsa Istanbul Real Estate Investment Trusts (REITs) Index and Borsa Istanbul 100 (BIST 100) Index. It focuses on three main points. First, we search whether there are variations in index returns and volatilities by days of the week, months of the year, and turn of the month patterns. Second, we ask whether REITs Index performance is closely related to stock market performance. Third, we test whether the abnormal returns in the process have significant effects on the index returns and volatilities. Results reveals that calendar anomalies still exist and the volatility pattern across days of the week and months of the year are statistically different. The return pattern observed between REITs and BIST 100 index is strong enough. REITs performance is closely related to stock market performance. BIST 100 abnormal returns have also significant effects on BIST 100 and REITs returns and volatilities. This study performs GARCH and EGARCH methodologies to and finds significant implications for local and international investors for designing trading strategies, drawing investment decisions, risk management, timing of security issuances by firms, asset pricing and performance evaluation.
Vehicles Assignment With Over-Emission Intensity Considerations: A Perspective on Integrating the Market Mechanism With Government Control

In this paper, we consider the effect of carbon emission regulations on the vehicles assignment optimization problem. We propose a mathematical model, in which the choice of vehicles (between the traditional and new environmental-friendly ones) and the proper assignments to customers are the decision variables. We introduce a new measure, called the over-emission intensity (OEI) factor, with which the government can control the amount of carbon emission of companies. Based on this proposal, we establish a new mechanism, known as the cap-and-trade program with OEI, and incorporate it into the optimization model. This novel model is then validated and used to study the impacts of OEI, carbon emission quota, emission price, and budget, on the operational performance and optimal decision of the company. We demonstrate the usefulness of the model by illustrating the effect of market regulation and government's macrocontrol on the reduction of carbon emission. We also show how the OEI affects the company's total cost, total amount of carbon emission, and the optimal vehicles assignment scheme. Finally, we argue that integrating the government macrocontrol scheme with the market mechanism is an effective measure.
Post-translational regulation of acid invertase activity by vacuolar invertase inhibitor affects resistance to cold-induced sweetening of potato tubers.

Cold-induced sweetening (CIS) is a serious post-harvest problem for potato tubers, which need to be stored cold to prevent sprouting and pathogenesis in order to maintain supply throughout the year. During storage at cold temperatures (below 10 °C), many cultivars accumulate free reducing sugars derived from a breakdown of starch to sucrose that is ultimately cleaved by acid invertase to produce glucose and fructose. When affected tubers are processed by frying or roasting, these reducing sugars react with free asparagine by the Maillard reaction, resulting in unacceptably dark-coloured and bitter-tasting product and generating the probable carcinogen acrylamide as a by-product. We have previously identified a vacuolar invertase inhibitor (INH2) whose expression correlates both with low acid invertase activity and with resistance to CIS. Here we show that, during cold storage, overexpression of the INH2 vacuolar invertase inhibitor gene in CIS-susceptible potato tubers reduced acid invertase activity, the accumulation of reducing sugars and the generation of acrylamide in subsequent fry tests. Conversely, suppression of vacuolar invertase inhibitor expression in a CIS-resistant line increased susceptibility to CIS. The results show that post-translational regulation of acid invertase by the vacuolar invertase inhibitor is an important component of resistance to CIS.
Comparative gel electrophoresis measurement of the DNA bend angle induced by the catabolite activator protein

We describe a method to determine the magnitude of protein‐induced DNA bends relative to a set of standard A tract bends using comparative gel electrophoresis. The DNA bend of interest was that induced by the catabolite activator protein (CAP), the transcriptional activator protein of the lac operon. The set of comparison molecules contained both bends of known magnitude and a bound CAP. The electrophoretic influence of the bound protein was accounted for by placing its binding site at the end of the molecule where its induced bend has little influence. Standard bends at the DNA center were introduced by incorporating 3–9 A6 tracts at ∼ 10.5 base‐pair phasing. The mobility of these control molecules was compared to the mobility of a test molecule of comparable length containing a central CAP‐induced DNA bend. The CAP bend angle was found to be 5.6 ± 0.3 A tract equivalents, or ∼ 100°, independent of the concentration of the gel used within the range tested. The dependence of gel retardation on DNA end‐to‐end distance was found to break down for A tract bend angles above 120°, corresponding roughly to the angle beyond which the long axis of the molecule is no longer parallel to the end‐to‐end vector. We speculate that this may reflect a switch in the mode of migration of molecules through the gel.
Nomenclature for antiviral‐resistant human hepatitis B virus mutations in the polymerase region

There is currently no universally accepted numbering convention for the antiviral drug‐related resistance mutations in the reverse transcriptase (rt) domain of the human hepatitis B virus (HBV) polymerase. The published inconsistencies have resulted from different HBV genotypes. A standardized numbering system for HBV polymerase is proposed. The new system is based on functional observations of HBV surface gene proteins (preS1, preS2, and HBsAg) and on the current convention used for human immunodeficiency virus type 1 (HIV‐1) polymerase proteins (protease, rt, and integrase), in which the amino acid numbering restarts at the first codon position of each domain. The HBV polymerase protein can be divided into 4 domains (terminal protein, spacer, rt, ribonuclease H) and each of these can be numbered separately. In this proposal, the HBV rt domain starts with the highly conserved EDWGPCDEHG motif, contains 344 amino acids, and the lamivudine‐related resistance mutations are found at amino acid rtL180M (previously amino acid 528, 526, 515, or 525) and rtM204V/I (previously 552, 550, 539, or 549). The new consensus rt domain numbering system is genotype independent and allows investigators to number any previously and newly discovered antiviral‐related amino acid change in a standardized manner.
An analysis of C-H...O and C-H...pi interactions in three substituted 4-ketotetrahydroindoles.

The crystal and molecular structures of the three 4-ketotetrahydroindoles 2-(4-chlorophenyl)-1-(4-fluorophenyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indol-4-one (C22H19ClFNO), (I), 1-(4-fluorophenyl)-2-(4-methoxyphenyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indol-4-one (C23H22FNO2), (II), and 6,6-dimethyl-1,2-diphenyl-4,5,6,7-tetrahydro-1H-indol-4-one (C22H21NO), (III), have been determined via single-crystal X-ray diffraction in order to study the intermolecular interactions therein. All three structures are stabilized via intermolecular C-H.O and C-H.pi interactions, generating different molecular motifs.
The Animal Models for Dengue Virus Infection

Currently, the mechanisms involved in the pathogenesis of DHF/DSS remain poorly understood and there is no effective vaccine available to prevent infection with DEN virus. The lack of a reliable small animal model that mimics dengue disease is a major obstacle. In this paper, the development of small animal models such as mice for dengue virus infections is reviewed.
Decreased sleep quality in patients suffering from retinitis pigmentosa

The purpose of this study was to assess the prevalence of sleep disturbance in subjects diagnosed with retinitis pigmentosa (RP), as well as the influence of age and gender. Sleep quality was assessed, by means of the Pittsburgh Sleep Quality Index (PSQI), in people with RP (n=177) and gender‐and age‐matched normally sighted individuals (n=491). The population was divided, according to their age, in eight decade groups. People on shift‐work, with affective disorders or with visual impairment other than RP, were excluded. The influence of cataracts in sleep quality was also studied in non‐RP people (n=57), with cataracts significantly impairing visual acuity. Another group of healthy controls (n=190) was studied in different seasons of the year for a possible seasonality in sleep disturbance. Global sleep quality decreased in an age‐dependent manner in RP‐patients, especially from the second decade of life. Retinitis pigmentosa‐patients showed, in relation to age‐matched controls: lower subjective sleep quality and efficiency, longer sleep latency, shorter sleep duration, higher daytime dysfunction and a higher use of sleeping medication. No significant differences in sleep quality were found among RP‐patients or controls depending either on their gender or on the presence of cataracts. Normal sighted individuals did not show seasonality in their sleep quality. We conclude that the sleep quality of RP‐patients decreases in an age‐dependent manner and points to the probably degeneration of photoreceptors mediating the photic input to the suprachiasmatic nuclei of the hypothalamus in this disease.
Recent Progress in Sawtooth Control

1 École Polytechnique Fédérale de Lausanne (EPFL), Centre de Recherches en Physique des Plasmas, Association EURATOM-Confédération Suisse, 1015 Lausanne, Switzerland 2UKAEA/Euratom Fusion Association, Culham Science Centre, Abingdon, UK 3Association Euratom-VR, KTH, SE-100 44 Stockholm, Sweden 4EFDA-JET CSU, Culham Science Centre, Abingdon, OX14 3DB, UK ∗ See the Appendix of F. Romanelli et al., Fusion Energy Conference 2008 (Proc. 22nd Int. FEC Geneva, 2008) IAEA, (2008)
Embedded Memory Interface Logic and Interconnect Testing

The increased size of embedded memory for system-on-chip (SoC) and multicore processors has a positive impact on performance yet poses a big challenge for chip yield, power consumption, and overall cost. Big percentage (>60%) of today's processors and SoC area in both 2-D (planar) and 3-D technologies, such as through silicon via (TSV), are dedicated to memory. Most of today's embedded memories are not as simple as a storage area with single interface of data, address, and control, but rather they compromise complex logic on their interface due to timing constrains and interconnect technologies (NoC and TSV). Memory core testing strategy is well understood and has mature tools and methodologies to screen for defects such as built-in-self-test (BIST). In addition, core and logic-based testing using scan and automatic test pattern generation (ATPG) tools and methodologies are intended for flop-based design. However, interface logic and complex interconnect like the one in 3-D chips are not thoroughly tested using BIST or ATPG as they are not designed for such logic. This becomes even more important for 3-D chips where a stack memory could have different testing strategies other than the base layer core which is interfacing with it. This brief presents a design for test methodology to achieve good coverage on interface logic for embedded and stack memory. The proposed approach uses modified ATPG and scan methodology to test the memory logic interface with minimum impact to existing design.