Miracle-dz/UniFAR-FTUs huggingface dataset:
Galanin and 5‐HT1A Receptor Interactions as an Integrative Mechanism in 5‐HT Neurotransmission in the Brain a

During recent years we have obtained evidence for the existence of galanid5 hydroxytryptamine (5-HT) interactions in the rat central nervous system. The main basis of these interactions appears to be bidirectional intramembrane interactions between galanin and 5-HTIA receptors, constituting an intramembrane feedback loop. '-2 This may represent a way to increase plasticity of 5-HT neurotransmission, inasmuch as the ~ H T , A receptor appears to be selectively modulated by galanin. ' Furthermore, we have evidence for the existence of galanin receptor subtypes, where galanin by the formation of active fragments can regulate its own actions.3A Interactions with 5-HTIA receptors play a key role in this regulati0n.4. ~ In the present paper we will review the evidence for galanid5-HT receptor interactions, consisting of both biochemical data from radioligand studies and physiological data from cardiovascular studies. In addition, results from signal transduction studies will be reviewed.
Can Social Media Predict Election Results? Evidence From New Zealand

The importance of social media for election campaigning has received a lot of attention recently. Using data from the 2011 New Zealand general election and the size of candidates’ social media networks on Facebook and Twitter, we investigate whether social media is associated with election votes and probability of election success. Overall, our results suggest that there is a statistically significant relationship between the size of online social networks and election voting and election results. However, the size of the effect is small and it appears that social media presence is therefore only predictive in closely contested elections.
Trajectories of Multiculturalism in Germany, the Netherlands and Canada: In Search of Common Patterns 1

Abstract In the mid-1990s, Canadian scholarship introduced an important distinction between historically incorporated national minorities and ethnic groups emerging from recent immigration. While the former may be accommodated through federal or multinational arrangements, multiculturalism has come to describe a normative framework of immigrant integration. The distinction between these analytically different types of movements is crucial for Taylor's and Kymlicka's influential theories, but the relations between different types of national and ethnic struggles for rights and recognition have remained unexplored in much of the subsequent scholarly literature. This article starts from a theoretical position where different types of diversity are viewed as highly interdependent in practice. Tracing the trajectories of multiculturalism in three different countries, the article aims to identify common patterns of how changing relations between traditionally incorporated groups affect public perceptions of and state responses to more recent immigration-induced diversity. More specifically, it asks the following question: to what extent does the absence (in Germany), discontinuation (in the Netherlands) and exacerbation (in Canada) of claims on ethnocultural grounds by traditionally incorporated groups influence the willingness of the national majority/ies to grant multicultural rights to immigrants?
Gendered themes in family reminiscing

Previous research conducted in laboratory settings has shown reliable gender differences in autobiographical memory. However, these studies have primarily focused on structural or emotional aspects of memory narratives told to an unfamiliar experimenter. The present study extends this literature by investigating gender differences in social references and interpersonal themes in parent-child narratives about the past. Participants were 17 white, middle-class children and their mothers and fathers, who were interviewed when children were 40 and 70 months of age. Parent-child narratives about shared activities in the past, as well as narratives about parents' own childhood, were examined. Results indicated that when discussing shared events, both parents talked in similar ways across children, although fathers referred to self more than mothers. However both parents referred to their girls more than their boys. Regarding event themes, parents discussed more social events with girls than with boys. Children themselves showed different gendered patterns; girls mentioned self and others, and relationships more than boys did, and children mentioned self and others more often when talking with fathers than with mothers. With respect to narratives about parents' childhood experiences, however, no gender differences were observed, save that parents referred to others more often in retrospective narratives told to girls than to boys. These findings suggest that gendered behaviours are best understood within the specific contexts and purposes of relational interactions.
Contraceptive self‐efficacy: A perspective on teenage girls' contraceptive behavior

This research investigated the relationship between the social‐psychological theory of self‐efficacy and teenage girls' contraceptive behavior. Data were obtained from 258 female clients, aged 20 or younger, of a family planning clinic. Four factors were extracted from the contraceptive self‐efficacy (CSE) scale developed for this investigation. Regression analyses were used to determine whether CSE scores distinguished patterns of contraceptive use when the effects of the influential demographic, sexual experience, and psychosocial variables were controlled. Two of the four CSE factors contributed significantly new information in accounting for the variance in the contraceptive use measure, semipartial R = . 26, semipartial R2 (4, 163) = . 07, p < . 01. The relationship between study variables and the four CSE factor scores were examined in a canonical correlation analysis to understand better the characteristics of the contraceptively self‐efficacious teenager. The results support the proposition that girl.
Generalized anxiety disorder, obsessive‐compulsive disorder and social phobia: sources of dissonance between ICD‐10 and DSM‐IV

The present study examined the diagnostic concordance between ICD‐10 and DSM‐IV in generalized anxiety disorder (GAD), obsessive‐compulsive disorder (OCD) and social phobia. The Composite International Diagnostic Interview was administered to 1504 people, in a sample derived from community and clinic cases, and discrepant diagnoses were identified for ICD‐10 and DSM‐IV GAD, OCD and social phobia. The initial analysis yielded 243 positive GAD, 41 positive OCD, and 190 positive social phobia diagnoses on one or the other classification, yet only 54%, 64%, and 39% of these respective diagnoses were concordant on both classifications. After removing potential errors with the ICD‐10‐DCR criteria for GAD and in the way the Composite International Diagnostic Interview (CIDI) and scorer operationalized the diagnostic criteria there were 426 diagnoses in the three disorders of which 298 (70%) were concordant. The residual discordance reflects the magnitude of the difference between the two diagnostic systems and researchers should be aware of this when they are making cross‐national comparisons of prevalence rates. Copyright © 1998 Whurr Publishers Ltd.
Gap Junctions between Interneuron Dendrites Can Enhance Synchrony of Gamma Oscillations in Distributed Networks

Gamma-frequency (30–70 Hz) oscillations in populations of interneurons may be of functional relevance in the brain by virtue of their ability to induce synchronous firing in principal neurons. Such a role would require that neurons, 1 mm or more apart, be able to synchronize their activity, despite the presence of axonal conduction delays and of the limited axonal spread of many interneurons. We showed previously that interneuron doublet firing can help to synchronize gamma oscillations, provided that sufficiently many pyramidal neurons are active; we also suggested that gap junctions, between the axons of principal neurons, could contribute to the long-range synchrony of gamma oscillations induced in the hippocampus by carbachol in vitro. Here we consider interneuron network gamma: that is, gamma oscillations in pharmacologically isolated networks of tonically excited interneurons, with frequency gated by mutual GABAAreceptor-mediated IPSPs. We provide simulation and electrophysiological evidence that interneuronal gap junctions (presumably dendritic) can enhance the synchrony of such gamma oscillations, in spatially extended interneuron networks. There appears to be a sharp threshold conductance, below which the interneuron dendritic gap junctions do not exert a synchronizing role.
Citizen attitudes toward advertising by public leisure service agencies

Abstract This study examines citizens’ attitudes toward advertising in general as well as toward public leisure service agencies. Data drawn from a five‐community survey of 497 Ontario households indicate that respondents hold mixed attitudes toward advertising in general and somewhat more positive attitudes toward advertising by public leisure service agencies. Respondents positively view public leisure service agencies’ use of advertising for information purposes, but have mixed attitudes toward the economic effects of advertising by those agencies. Using a K‐means cluster analysis, three citizen groups were identified on the basis of their involvement with public leisure services. Individuals involved at a high or functional level with public leisure services are more likely to hold positive attitudes toward advertising by these agencies as compared to those individuals who are not involved with public leisure service agencies (p < .05). The data suggest that citizens may be accepting of public leisure service agencies using a broader spectrum of promotional techniques.
Residual Complexes Containing SMARCA2 (BRM) Underlie the Oncogenic Drive of SMARCA4 (BRG1) Mutation

ABSTRACT Collectively, genes encoding subunits of the SWI/SNF (BAF) chromatin remodeling complex are mutated in 20% of all human cancers, with the SMARCA4 (BRG1) subunit being one of the most frequently mutated. The SWI/SNF complex modulates chromatin remodeling through the activity of two mutually exclusive catalytic subunits, SMARCA4 and SMARCA2 (BRM). Here, we show that a SMARCA2-containing residual SWI/SNF complex underlies the oncogenic activity of SMARCA4 mutant cancers. We demonstrate that a residual SWI/SNF complex exists in SMARCA4 mutant cell lines and plays essential roles in cellular proliferation. Further, using data from loss-of-function screening of 165 cancer cell lines, we identify SMARCA2 as an essential gene in SMARCA4 mutant cancer cell lines. Mechanistically, we reveal that Smarca4 inactivation leads to greater incorporation of the nonessential SMARCA2 subunit into the SWI/SNF complex. Collectively, these results reveal a role for SMARCA2 in oncogenesis caused by SMARCA4 loss and identify the ATPase and bromodomain-containing SMARCA2 as a potential therapeutic target in these cancers.
Study on the interconnection architecture and access technology for Internet of Things

Internet of Things (IOT) is a novel paradigm developed on the basis of existing technologies and closely related to RFID, WSN, CPS, Pervasive Computing and M2M (Machine to Machine). IOT has broad prospects in transportation, logistics, healthcare, smart environment, personal living and social domain. This paper researches on the concept, characteristics and supporting technology of IOT, proposes an interconnection architecture of IOT from the view of business process and data flow. Then agent-based and 6LoWPAN-based access models towards sensors or sensor embedded things in IOT are presented and discussed. Eventually, supporting technologies of IOT are summarized.
Deconstructing Cosmetic Virtual Goods Experiences in Dota 2

Cosmetic items do not provide functional advantages in games, but, nevertheless, they play an important role in the overall player experience. Possessing predominantly socially-constructed dimensions of value, cosmetic items are chosen, discussed, assessed, and valuated in an ongoing iterative collaborative process by communities of players. In our study, we explore the case of Dota 2 and apply Topic Modeling to community-discussions data gathered from Reddit.com. We describe social experiences related to the valuation of cosmetic items in interaction and collision of various logics, including artificial scarcity, decomposition of visual effects, and connectedness to the game lore. Our findings connect the collective experience of players in the game and on online community platforms, suggesting that non-utility-based social value construction becomes an important part of game experience.
Functional shoulder ratios with high velocities of shoulder internal rotation are most sensitive to determine shoulder rotation torque imbalance: a cross-sectional study with elite handball players and controls

Abstract The aim of the present study was to determine which approach to calculating shoulder ratios is the most sensitive for determining shoulder torque imbalance in handball players. Twenty-six participants (handball athletes, n = 13; healthy controls, n = 13) performed isokinetic concentric and eccentric shoulder internal rotation (IR) and external rotation (ER) assessment at 60, 180 and 300°/s. We used eight approaches to calculating shoulder ratios: four concentric (i.e. concentric ER torque divided by concentric IR torque), and four functional (i.e. eccentric ER torque divided by concentric IR torque) at the velocities of 60, 180 and 300°/s for both IR and ER, and combining 60°/s of ER and 300°/s of IR. A three factorial ANOVA (factors: shoulder ratios, upper limb sides, and groups) along with Tukey’s post-hoc analysis, and effect sizes were calculated. The findings suggested the functional shoulder ratio combining 60°/s of ER and 300°/s of IR is the most sensitive to detect differences between upper limbs for handball players, and between players and controls for the dominant side. The functional shoulder ratio combining 60°/s of ER with 300°/s of IR seems to present advantages over the other approaches for identifying upper limb asymmetries and differences in shoulder torque balance related to throwing.
Tracking Human Faces in Real-Time,

Abstract : Many applications in human computer interaction (HCI) require tracking a human face. In this report, we address two important issues for tracking human faces in real-time: what to track and how to track. We present a stochastic model to characterize skin-colors of human faces. The information provided by the model is sufficient for tracking a human face in a various poses and views. The model can be adapted in real time for different people and different lighting conditions while a person is moving. We then present a model-based approach to implement a real-time face tracker. The system has achieved a rate of up to 30+ frames/second using an HP-9000 workstation with a framegrabber and a Canon VC-Cl camera. It can track a person's face while the person moves freely (e.g., walks, jumps, sits down and stands up) in a room. Three types of models have been employed to track human faces. In addition to the skin-color model used to register the face, a motion model is used to estimate image motion and to predict search window; and a camera model is used to predict and to compensate for camera motion (panning, tilting, and zooming). The system can be applied to tele-conferencing and many human-computer interactive applications such as lip-reading and gaze tracking. The principle in developing this system can be extended to other tracking problems such as tracking the human hand for gesture recognition.
Analysis, Isolation, and Activation of Antigen-Specific CD4+ and CD8+ T Cells by Soluble MHC-Peptide Complexes

T cells constitute the core of adaptive cellular immunity and protect higher organisms against pathogen infections and cancer. Monitoring of disease progression as well as prophylactic or therapeutic vaccines and immunotherapies call for conclusive detection, analysis, and sorting of antigen-specific T cells. This is possible by means of soluble recombinant ligands for T cells, i.e., MHC class I-peptide (pMHC I) complexes for CD8+ T cells and MHC class II-peptide (pMHC II) complexes for CD4+ T cells and flow cytometry. Here we review major developments in the development of pMHC staining reagents and their diverse applications and discuss perspectives of their use for basic and clinical investigations.
Postgraduate research success: communities of practice involving cohorts, guardian supervisors and online communities

Traditionally, supervisors work with students on an individual basis and postgraduate development programmes are run on site. However, with increasing numbers of part‐time and international students, supervisory relationships are likely to be conducted at a distance as students study alongside other commitments. Isolation can often be a key feature for many postgraduates, whether based in the same institution as the supervisor and more particularly for international students or those studying at a distance. It can also be an issue for their supervisors. However, in this age of electronic communication, interactions at a distance should be able to be at least as robust as many of those conducted face to face. More broadly, the international research community is something generally cited as the context for research work, supervision, study and publication more generally. Entry firstly into the university academic community, and then into the larger global research community can be enabled, we would argue, by the support of communities of practice from the outset of postgraduate students’ and supervisors’ interactions. In this context, considerable numbers of international postgraduates at Anglia Ruskin University (UK) and their supervisors are being effectively supported through three innovations which build institutionally related communities of practice: (1) Guardian supervisors work with the students on research development programmes, with accompanying meetings organised during and round programme workshops, which focus throughout on strategies of meta‐learning. Subsequently they support students’ work at a distance with emails, and webcam correspondence. (2) PhD students are empowered to develop mutual, critically focused support for each other’s work through the enhanced use of the cohort in the compulsory research development workshops and through ongoing discussion lists, self‐help groups and symposia. (3) Supervisors of international postgraduates are supported as a community of practice through the revision of online supervisory discussion and development. This paper is based on action research carried out with current and graduate students, guardian supervisors and supervisors as collaborators to explore the rationale, problems, practices and the richness of the experience of working with a system which fosters communities of practice, involving guardian supervisors, distance supervisors and postgraduate cohorts.
Relationship among Nurses' Attitude on Job Rotation, Job Stress and Organizational Commitment

Purpose: The purpose of study was to identify the relationships among attitude on job rotation, job stress and organizational commitment of hospital nurses. Methods: The data were collected from the self-reported questionnaire responses of 430 nurses from Sep. 1 to Sep. 30, 2010 at a university hospital in D city and analyzed by descriptive statistics, t-test, ANOVA, Scheff test and Pearson correlation coefficients. Results: Nurses who experienced job rotation showed negative attitude on job rotation (t
Movement of Bax from the Cytosol to Mitochondria during Apoptosis

Bax, a member of the Bcl-2 protein family, accelerates apoptosis by an unknown mechanism. Bax has been recently reported to be an integral membrane protein associated with organelles or bound to organelles by Bcl-2 or a soluble protein found in the cytosol. To explore Bcl-2 family member localization in living cells, the green fluorescent protein (GFP) was fused to the NH2 termini of Bax, Bcl-2, and Bcl-XL. Confocal microscopy performed on living Cos-7 kidney epithelial cells and L929 fibroblasts revealed that GFP–Bcl-2 and GFP–Bcl-XL had a punctate distribution and colocalized with a mitochondrial marker, whereas GFP–Bax was found diffusely throughout the cytosol. Photobleaching analysis confirmed that GFP–Bax is a soluble protein, in contrast to organelle-bound GFP–Bcl-2. The diffuse localization of GFP–Bax did not change with coexpression of high levels of Bcl-2 or Bcl-XL. However, upon induction of apoptosis, GFP–Bax moved intracellularly to a punctate distribution that partially colocalized with mitochondria. Once initiated, this Bax movement was complete within 30 min, before cellular shrinkage or nuclear condensation. Removal of a COOH-terminal hydrophobic domain from GFP–Bax inhibited redistribution during apoptosis and inhibited the death-promoting activity of both Bax and GFP– Bax. These results demonstrate that in cells undergoing apoptosis, an early, dramatic change occurs in the intracellular localization of Bax, and this redistribution of soluble Bax to organelles appears important for Bax to promote cell death.
Models, methods, and applications of econometrics : essays in honor of A.R. Bergstrom

The contributions of A.R. Bergstrom to econometrics, P.C. B Phillips and A.R. Bergstrom continuous time models, Marcus J. Chambers et al finite sample theory contributions, Roger J. Bowden et al dynamic econometric modelling, Roger Bowden et al empirical applications, Terence Agbeyegbe et al.
Emergency Management of Hypertension in Children

Systemic arterial hypertension in children has traditionally been thought to be secondary in origin. Increased incidence of risk factors like obesity, sedentary life-styles, and faulty dietary habits has led to increased prevalence of the primary arterial hypertension (PAH), particularly in adolescent age children. PAH has become a global epidemic worldwide imposing huge economic constraint on health care. Sudden acute increase in systolic and diastolic blood pressure can lead to hypertensive crisis. While it generally pertains to secondary hypertension, occurrence of hypertensive crisis in PAH is however rare in children. Hypertensive crisis has been further subclassified depending on presence or absence of end-organ damage into hypertensive emergency or urgency. Both hypertensive emergencies and urgencies are known to cause significant morbidity and mortality. Increasing awareness among the physicians, targeted at investigation of the pathophysiology of hypertension and its complications, better screening methods, generation, and implementation of novel treatment modalities will impact overall outcomes. In this paper, we discuss the etiology, pathogenesis, and management of hypertensive crisis in children. An extensive database search using keywords was done to obtain the information.
¿Donde Estan los Estudiantes Puertorriquenos/os Exitosos? [Where Are the Academically Successful Puerto Rican Students?]: Success Factors of High-Achieving Puerto Rican High School Students

This article describes the 4 success factors that 10 working class Puerto Rican urban high school students attributed to their high academic achievement. These success factors were (a) the acquisition of social capital through religiosity and participation in school and community-based extracurricular activities, (b) having a strong Puerto Rican identity, (c) the influence of these students' mothers on their academic achievement, and (d) the potential for caring teachers and other school staff to influence high academic achievement. These findings have implications for Latino/a education and recommendations are provided.