Miracle-dz/UniFAR-FTUs huggingface dataset:
Transient modeling/analysis of hyperbolic heat conduction problems employing mixed implicit-explicit alpha method

This paper describes the evaluation of mixed implicit-explicit finite element formulations for hyperbolic heat conduction problems in volving non-Fourier effects. In particular, mixed implicit-explicit formulations employing the α method proposed by Hughes et at, [1, 2] are described for Ike numerical simulation of hyperbolic heat conduction models, which involves time-dependent relaxation effects. Existing analytical approaches for modeling! analysis of such models involve complex mathematical formulations for obtaining closed-form solutions, while in certain numerical formulations the difficulties include severe oscillatory solution behavior (which often disguises the true response) in the vicinity of the thermal disturbances, which propagate with finite velocities. In view of these factors, the a method is evaluated to assess the control of the amount of numerical dissipation for predicting the transient propagating thermal disturbances. Numerical test models are presented, and pertinent conclusions ar.
APPROXIMATION PROPERTIES OF TP MODEL FORMS AND ITS CONSEQUENCES TO TPDC DESIGN FRAMEWORK

Tensor Product Distributed Compensation (TPDC) is a recently established controller design framework, that links TP model transformation and Parallel Distributed Compensation (PDC) framework. TP model transformation converts different models to a common representational form: the TP model form. The primary aim of this paper is to investigate the approximation capabilities of TP model forms, because the universal applicability of TPDC framework strongly relies on it. We point out that the set of functions that can be approximated arbitrarily well by TP forms with bounded number of components lies no‐where dense in the set of continuous functions. Consequently, in a class of control problems this property necessitates the usage of tradeoff techniques between the accuracy and the complexity of the TP form, which is easily feasible within the TPDC framework unlike in analytic models.
Dissipation in helical turbulence

In helical turbulence a linear cascade of helicity accompanying the energy cascade has been suggested. Since energy and helicity have different dimensionality we suggest the existence of a characteristic inner scale, ξ=kH−1, for helicity dissipation in a regime of hydrodynamic fully developed turbulence and estimate it on dimensional grounds. This scale is always larger than the Kolmogorov scale, η=kE−1, and their ratio η/ξ vanishes in the high Reynolds number limit, so the flow will always be helicity free in the small scales.
Etendue efficient coupling of light using dual paraboloid reflectors for projection displays

With the introduction of Digital Micromirror Device (DMD) and Liquid Crystal on Silicon (LCOS) technologies, imagers for projection displays become increasingly smaller, thus requiring more intense, focused light with lower etendue values. To illuminate these smaller imagers, a patented dual paraboloid reflector system has been developed to collect and focus light from an arc lamp onto the imager without loss of brightness. This powerful optical platform provides the control and etendue efficiency that has been missing in standard illumination sy stems. The dual paraboloid reflector system consists of two parabolic reflectors placed symmetrically facing each other. The first parabolic reflector collects and collimates it into a parallel beam. The second parabolic reflector intercepts the parallel beam and focuses the light with unity magnification, i.e. 1:1 imaging, into a tapered light pipe (TLP) with conserved brightness. The TLP transforms the focused light into an output with the needed area, shape, and numerical aperture (NA). It also acts as a homogenizer so that the intensity profile at the output surface is uniform and eventually provides a uniform intensity profile at the screen. The reflection of light twice in the dual paraboloid reflector system provides a high IR and UV rejection ratios, resulting in less degradation of the optical components. Polarization and color recycling systems are also designed taking advantage of this reflector configuration.
Origanum vulgare Essential Oil Modulates the AFB1-Induced Oxidative Damages, Nephropathy, and Altered Inflammatory Responses in Growing Rabbits

The current study was performed to investigate the toxic effects of aflatoxin B1 (AFB1) through the evaluation of kidney function tests and histopathological examination of renal tissues, targeting the therapeutic role of Marjoram (Origanum vulgare essential oil-OEO) in improving health status. Forty-eight New Zealand Whites growing rabbits (four weeks old) weighing on average 660.5 ± 2.33 g were randomly and equally distributed into four groups, each of which had four replicas of three animals as the following: Control group (only basal diet), AFB1 group (0.3 mg AFB1/kg diet), OEO group (1 g OEO/kg diet) and co-exposed group (1 g OEO/kg + 0.3 mg AF/kg diet). Our study lasted eight weeks and was completed at 12 weeks of age. The results revealed that OEO decreased the toxic effects of AFB1 in rabbit kidneys by substantially reducing the cystatin C levels in the AFB1 group. Additionally, OEO decreased oxidative stress and lipid peroxidation levels in the co-exposed group. Moreover, OEO reduced DNA damage and inflammatory response in addition to the down-regulation of stress and inflammatory cytokines-encoding genes. Besides, OEO preserved the cytoarchitecture of rabbits’ kidneys treated with AFB1. In conclusion, O. vulgare essential oil supplementation ameliorated the deleterious effects of AFB1 on the rabbits’ kidneys by raising antioxidant levels, decreasing inflammation, and reversing oxidative DNA damage.
Endo-Lysosomal and Autophagy Pathway and Ubiquitin-Proteasome System in Mood Disorders: A Review Article

Abstract Mood disorders are disabling conditions that cause significant functional impairment. Due to the clinical heterogeneity and complex nature of these disorders, diagnostic and treatment strategies face challenges. The etiology of mood disorders is multifactorial, involving genetic and environmental aspects that are associated with specific biological pathways including inflammation, oxidative stress, and neuroprotection. Alterations in these pathways may reduce the cell’s ability to recover from stress conditions occurring during mood episodes. The endo-lysosomal and autophagy pathway (ELAP) and the ubiquitin-proteasome system (UPS) play critical roles in protein homeostasis, impacting neuroplasticity and neurodevelopment. Thus, emerging evidence has suggested a role for these pathways in mental disorders. In the case of neurodegenerative diseases (NDDs), a deeper understanding in the role of ELAP and UPS has been critical to discover new treatment targets. Since it is suggested that NDDs and mood disorders share clinical symptomatology and risk factors, it has been hypothesized that there might be common underlying molecular pathways. Here, we review the importance of the ELAP and UPS for the central nervous system and for mood disorders. Finally, we discuss potential translational strategies for the diagnosis and treatment of major depressive disorder and bipolar disorder associated with these pathways.
Quantitative CT Metrics for the Prediction of Therapeutic Effect in Asthma

Background: Few studies have explored the correlation between asthma medication and features on HRCT images. We aim to analyse the differences and temporal changes of lung function and airway resistance in asthma with diverse HRCT phenotypes in a short period after inhalation of budesonide/formoterol. Method: This observational study recruited 55 adult patients with varying severities of asthma. We performed detailed airway metrics measurements of chest CT scans, such as airway wall thickness (WT), wall area percentage (WA%), wall thickness percentage (T/OR), and airways with an inner perimeter of 10 mm (Pi10). The effect of lung structural features on asthma medication response was explored according to the WA% and T/OR twelve hours post-drug administration. Using multivariable regression models, we then assessed the influence of WA% on lung function. Results: WA% (p < 0.001) and T/OR (p < 0.001) significantly increased in asthma than in healthy control subjects. Compared to mild asthma, airway walls were further thickened (WA%, p = 0.023; T/OR: p = 0.029) and associated with lumen narrowing (Pi10, p = 0.055) in moderate to severe asthma. WA% and T/OR correlated well with lung function (FEV1, FVC, MMEF, and PEF) and airway resistance (R5, R20, Rp, and Fres). Regression analysis showed that MEF25 decreased with increasing age and WA% (R2 = 0.58, p < 0.001). Patients with thickened airway walls experienced a maximal increase in FVC, FEV1, and PEF at 2 h (p < 0.001) and a maximal decrease of R5, Z5, and Rp at 2 h (p < 0.001) in those with a thickened airway pattern. Conclusions: Asthma patients with different bronchial wall thicknesses exhibited variable lung function changes. Specifically, patients with thick airway wall patterns were more sensitive to inhaled budesonide in the short term.
A novel approach for simultaneous detection of the most common food-borne pathogens by multiplex qPCR

Food contaminated with bacterial pathogens is a great threat to human health and food spoilage, having an impact on public health and the food industry. Research in food safety seeks to develop a practical, rapid, and sensitive detection technique for food-borne pathogens. In the past few decades, real-time quantitative polymerase chain reaction (qPCR) has been developed, and multiplex qPCR is a preferred feature. Multiplex qPCR enables the simultaneous amplification of many targets of interest in one reaction by using more than one pair of primers. In this study, we have developed and evaluated a hydrolysis (TaqMan) probe-based system for simultaneous detection of eight of the most common food-borne pathogens in a single-step procedure by multiplex qPCR. A multicolor combinational probe coding (MCPC) strategy was utilized that allows multiple fluorophores to label different probes in combinatorial manner. This strategy enabled simultaneous detection, identification, and quantification of targeted genes. The efficiency of the individual qPCR reactions for each target gene had values comparable to those established for multiplex qPCR, with detection limits of approximately < 10 copies of DNA per reaction. Pathogen load helps to predict bacteriological quality status in food products and serves to validate the efficiency of procedures to minimize or eliminate their presence, so newly developed multiplex qPCR was quantitative for each pathogen. During sample preparation, a step to concentrate the target organism from a relatively large sample size, remove all potential PCR inhibitors, and yield samples in a volume suitable for qPCR was incorporated.
Particle motion in resonance tubes

Small particle motions in standing or travelling acoustic waves are well known and extensively studied. Particle motion in weak shock waves has been studied much less, especially particle motion in periodic weak shock waves which as yet has not been dealt with. The present study considers small particle motions caused by weak periodic shock waves in resonance tubes filled with air. A simple mathematical model is developed for resonance gas oscillations under the influence of a vibrating piston with a finite amplitude at the first acoustic resonance frequency. It is shown that a symmetrical sinusoidal piston motion generates non-symmetric periodic shock waves. A model of particle motion in such a flow field is suggested. It is found that non-symmetric shock waves cause particle drift from the middle cross-section toward the ends of the resonance tube. The velocity of particle drift is found to be of the order of Dpρp/ Trρg, where Dp is the particle diameter, Tr the period of the resonance oscillation, ρp and ρg are the particle and gas density, respectively. At the same time, the velocity drift strongly depends on the ratio τ/Tr, where τ is the particle relaxation time. Particle drift is vigorous when τ/Tr∼1 and insignificant when τ/Tr 1. Theoretical predictions of particle drift in resonance tubes are verified numerically as well as experimentally. When the particle relaxation time is much smaller than period of the resonance oscillations particles perform oscillations around their equilibrium positions with amplitude of the order of Dpρp/ρg. It is shown that the difference in oscillation amplitude of particle of difference sizes explains coalescence of aerosol droplets observed in experiments of Temkin (1970). The importance of the phenomena for particle separation, coagulation and transport processes is discussed.
Semiparametric Estimation of a Duration Model

Within the framework of the proportional hazard model proposed in Cox (1972), Han and Hausman (1990) consider the logarithm of the integrated baseline hazard function as constant in each time period. We, however, proposed an alternative semiparametric estimator of the parameters of the covariate part. The estimator is considered as semiparametric since no prespecified functional form for the error terms (or certain convolution) is needed. This estimator, proposed in Lewbel (2000) in another context, shows at least four advantages. The distribution of the latent variable error is unknown and may be related to the regressors. It takes into account censored observations, it allows for heterogeneity of unknown form and it is quite easy to implement since the estimator does not require numerical searches. Using the Spanish Labour Force Survey, we compare empirically the results of estimating several alternative models, basically on the estimator proposed in Han and Hausman (1990) and our semiparametric estimator. Copyright 2001 by Blackwell Publishing Ltd
A Numerical Heat Transfer Analysis of Strip Rolling

The lack of a practical mathematical model to simulate thermal behavior of the metal rolling process has forced mill operators and designers to rely on plant experience and testing, which is time consuming and expensive. An effective finite difference model has been developed to study the temperature profiles of the work roll and the strip. Several finite difference techniques have been successfully employed to cope with the special characteristics of the rolling process, such as very high velocity, high temperature variation in a very thin layer, curved boundary, and bimaterial interface. Typical rolling conditions were analyzed to provide temperature information on the roll and strip. Both cold and hot rollings were considered, and the effect of changing velocities was also studied. Good correspondence is found when present results are compared with either analytical solutions under simplified rolling conditions or measured data.
Discretized skew‐t mixture model for deconvoluting liquid chromatograph mass spectrometry data

In this paper, new statistical algorithms for accurate peak detection in the metabolomic data are proposed. Specifically, liquid chromatograph‐mass spectrometry data are analyzed. The discretized skew‐t mixture model for peak detection is proposed. It shows great flexibility and capability in fitting skewed or heavy‐tailed peaks. The methodology is further extended to cross‐sample peak alignment for identifying the true peaks. A measure of peak credibility is provided through the assessment of misclassification probabilities between two cross‐sample peaks. The proposed algorithms are applied to spike‐in data with promising results.
Hopkins Ultraviolet Telescope Observations of U Geminorum Far from Outburst

The Hopkins Ultraviolet Telescope was used during the Astro-2 Space Shuttle mission to obtain a far-ultraviolet (820-1840 Å) spectrum of the dwarf nova U Geminorum in its low state. At the time of the observation, U Gem had been at optical minimum for 185 days. The HUT spectrum is dominated by the white dwarf star, and shows (among other things) very strong, broad hydrogen Lyman absorption lines. A comparison with solar abundance white dwarf models indicates a temperature near ~30,000 K. Comparison to a similar spectrum obtained during the Astro-1 mission in 1990, only 10 days after U Gem had returned to the low state following a normal outburst, confirms that the average temperature of the white dwarf in U Gem drops substantially between outbursts. Furthermore, differences between the models and the data at the shortest wavelengths in both spectra support the hypothesis that the surface temperature is nonuniform and that a decrease in the relative importance of a hot region, possibly a belt, on the surface of the white dwarf causes the observed 30% decline in flux at 1450 Å far from outburst.
Assessment of nutritive value, gas and methane production, fermentation of ensiled mixtures of sorghum–cluster bean

ABSTRACT This study was conducted to investigate the effects of different mixture ratios of sorghum (S) and cluster bean (CB) on fermentation parameters, nutritional composition, and gas-methane production of mixture silages. Five different mixture ratios (100%S, 75%S+25%CB, 50%S+50CB, 25%S+75%CB and 100%CB) were used in this study. Effects of mixture ratios on entire parameters were highly significant (p ≤ 0.01). Decreasing ADF and NDF ratios and increasing crude protein, ash and oil contents and condensed tannin levels were observed with increasing cluster bean ratios of the mixtures. However, cluster beans reduced WSC and lactic acid and increased pH, butyric acid and ethanol contents. The lowest Fleig score was obtained from cluster bean silage (100%CB). The lowest gas-methane production was obtained from cluster bean silage and the greatest ME and NEL values were obtained from sorghum silage (100%S). The best OMD values were obtained from sorghum silage and 75%S+25%CB mixture silage. The present findings revealed that a 50%S+50%CB mixture yielded high nutritional composition and good fermentation parameters.
Metal–Organic Frameworks and Their Biodegradable Composites for Controlled Delivery of Antimicrobial Drugs

Antimicrobial resistance (AMR) is a growing global crisis with an increasing number of untreatable or exceedingly difficult-to-treat bacterial infections, due to their growing resistance to existing drugs. It is predicted that AMR will be the leading cause of death by 2050. In addition to ongoing efforts on preventive strategies and infection control, there is ongoing research towards the development of novel vaccines, antimicrobial agents, and optimised diagnostic practices to address AMR. However, developing new therapeutic agents and medicines can be a lengthy process. Therefore, there is a parallel ongoing worldwide effort to develop materials for optimised drug delivery to improve efficacy and minimise AMR. Examples of such materials include functionalisation of surfaces so that they can become self-disinfecting or non-fouling, and the development of nanoparticles with promising antimicrobial properties attributed to their ability to damage numerous essential components of pathogens. A relatively new class of materials, metal–organic frameworks (MOFs), is also being investigated for their ability to act as carriers of antimicrobial agents, because of their ultrahigh porosity and modular structures, which can be engineered to control the delivery mechanism of loaded drugs. Biodegradable polymers have also been found to show promising applications as antimicrobial carriers; and, recently, several studies have been reported on delivery of antimicrobial drugs using composites of MOF and biodegradable polymers. This review article reflects on MOFs and polymer–MOF composites, as carriers and delivery agents of antimicrobial drugs, that have been studied recently, and provides an overview of the state of the art in this highly topical area of research.
Ultrasound-Guided Stellate Ganglion Radiofrequency in a Patient with Ventricular Tachycardia Sensitive to Implantable Cardioverter Defibrillator: A Case Report

Introduction Electrical storms and ventricular tachycardia are two life-threatening arrhythmias that are becoming more common. In developing ventricular arrhythmias, the sympathetic nervous system plays a vital role. Stellate ganglion (SG) block can be used in many situations as an important therapeutic target, like treating tachyarryhthmias and ventricular tachyarrhythmias. Case Presentation The patient was a 53 years old woman with a history of implantable cardioverter defibrillator (ICD) insertion due to ventricular tachycardia. The patient complained of an awkward and unpleasant sensation when the ICD sensed the tachyarrhythmia and shocked her. Regarding the positive response to the previous SG block, with the goal of a longer duration of this effect, stellate ganglion radiofrequency was performed. Conclusions Stellate ganglion radiofrequency shows a safe and long-term effect for patients with tachyarrhythmias and ICD who cannot tolerate episodes of ICD activation.
Monte Carlo simulation of hot-phonon and degeneracy effects in the AlGaN/GaN two-dimensional electron gas channel

Ensemble Monte Carlo simulation of two-dimensional electron transport is carried out for an AlGaN/GaN heterostructure channel subjected to an electric field applied in the plane of electron confinement. The envelope wavefunctions for the confined electrons are calculated using a self-consistent Poisson–Schrodinger solver. The effects of electron-gas degeneracy and hot phonons on electron energy relaxation and drift velocity are investigated. The best fit between Monte Carlo simulation and experimental results is received with optical-phonon relaxation time τph = 1 ps. The results of simulation show that the degeneracy reduces the electron drift velocity while the hot phonons reduce the electron drift velocity and increase the electron energy relaxation time. Electron energy relaxation time approaches 0.3 ps at 10 kV cm−1 at room temperature.