Miracle-dz/UniFAR-FTUs huggingface dataset:
WeiboEvents: A Crowd Sourcing Weibo Visual Analytic System

In this work, we propose a visual analytic system for analyzing events of Weibo, a Chinese-version microblog service. We build a system which consists of two interfaces: a web-based online visualization interface for public users and an offline expert visual analytic system which wraps the online one and provides additional analysis functions. The online interface provides an intuitive and powerful retweet tree visualization which inspires users' creativity. The expert system adopts public users' analysis results collected from the web interface, and can visualize and analyze Weibo events to a deeper extent.
Frame rules from answer types for code pointers

We define a type system, which may also be considered as a simple Hoare logic, for a fragment of an assembly language that deals with code pointers and jumps. The typing is aimed at local reasoning in the sense that only the type of a code pointer is needed, and there is no need to know the whole code itself. The main features of the type system are separation logic connectives for describing the heap, and polymorphic answer types of continuations for keeping track of jumps. Specifically, we address an interaction between separation and answer types: frame rules for local reasoning in the presence of jumps are recovered by instantiating the answer type. However, the instantiation of answer types is not sound for all types. To guarantee soundness, we restrict instantiation to closed types, where the notion of closedness arises from biorthogonality (in a sense inspired by Krivine and Pitts). A machine state is orthogonal to a disjoint heap if their combination does not lead to a fault. Closed types are sets of machine states that are orthogonal to a set of heaps. We use closed types as well-behaved answer types.
Intrathymic deletion of MHC class I‐restricted cytotoxic T cell precursors by constitutive cross‐presentation of exogenous antigen

Cross‐priming of cytotoxic T lymphocytes by professional antigen‐presenting cells (APC) is a potential hazard to self tolerance because it exposes naive T cells to tissue‐specific self antigens in the context of co‐stimulatory signals. Here we show that cross‐presentation of exogenous material occurs constitutively within the thymus. Although efficient cross‐presentation is a property of relatively few APC it results in thymocyte deletion both in vitro and in vivo, suggesting that intrathymic cross‐presentation can operate as an effective component of tolerance to circulating self antigens. The capacity of minor cell populations to mediate thymocyte deletion but not positive selection reflects an underlying difference in the biology of these two processes.
Proteo: A New Approach t o Network-on-Chip

The purpose of this paper is to present the basic ideas behind the development of our Network-on-Chip (NoC) architecture, called “Proteo”. In an Intellectual Property (IP) based design methodology the interconnection structures may be treated as IPs. The Proteo project is aimed at creating a library of pre-designed communication blocks that can be selected from a component library and configured by automated tools. The network implements packet switching in a hierarchical topology. A NoC needs a considerable amount of resources that can be shared with other system level tasks, like powersaving and fault-tolerance mechanisms.
Ral-regulated interaction between Sec5 and paxillin targets Exocyst to focal complexes during cell migration

Changes in cellular behavior that cause epithelial cells to lose adhesiveness, acquire a motile invasive phenotype and metastasize to secondary sites are complex and poorly understood. Molecules that normally function to integrate adhesive spatial information with cytoskeleton dynamics and membrane trafficking probably serve important functions in cellular transformation. One such complex is the Exocyst, which is essential for targeted delivery of membrane and secretory proteins to specific plasma membrane sites to maintain epithelial cell polarity. Upon loss of cadherin-mediated adhesion in Dunning R3327-5′A prostate tumor cells, Exocyst localization shifts from lateral membranes to tips of protrusive membrane extensions. Here, it colocalizes and co-purifies with focal complex proteins that regulate membrane trafficking and cytoskeleton dynamics. These sites are the preferred destination of post-Golgi transport vesicles ferrying biosynthetic cargo, such as α5-integrin, which mediates adhesion of cells to the substratum, a process essential to cell motility. Interference with Exocyst activity impairs integrin delivery to plasma membrane and inhibits tumor cell motility and matrix invasiveness. Localization of Exocyst and, by extension, targeting of Exocyst-dependent cargo, is dependent on Ral GTPases, which control association between Sec5 and paxillin. Overexpression of Ral-uncoupled Sec5 mutants inhibited Exocyst interaction with paxillin in 5′A cells, as did RNAi-mediated reduction of either RalA or RalB. Reduction of neither GTPase significantly altered steady-state levels of assembled Exocyst in these cells, but did change the observed localization of Exocyst proteins.
Time-Delay Switch Attack on Load Frequency Control in Smart Grid

Current smart power grids have communication infrastructure to improve efficiency, reliability and sustainability of supply. However, their open communication architecture makes them vulnerable to cyber-attacks with potentially catastrophic consequences. In this paper, we propose a new model of time-delay switch (TDS) attack by introducing different time delays to each state in the dynamics of a power system. This means, we delay the telemetered sensed state of a plant by a specific amount of time delay for some specified attack time. Such an attack will have devastating consequences or introduce hidden inefficiency on smart grids if no prevention measures are considered in the design of these power systems. Here we will consider examples of the effects of the TDS attack on the dynamic performance of a power system. To do this, we first formulated a state space model of a smart power grid system under TDS attack using a hybrid systems approach. Then we prove by analysis and demonstrate by simulations how a TDS attack can be used to sabotage and destabilize a smart grid.
MAGE-C2–Specific TCRs Combined with Epigenetic Drug-Enhanced Antigenicity Yield Robust and Tumor-Selective T Cell Responses

Adoptive T cell therapy has shown significant clinical success for patients with advanced melanoma and other tumors. Further development of T cell therapy requires improved strategies to select effective, yet nonself-reactive, TCRs. In this study, we isolated 10 TCR sequences against four MAGE-C2 (MC2) epitopes from melanoma patients who showed clinical responses following vaccination that were accompanied by significant frequencies of anti-MC2 CD8 T cells in blood and tumor without apparent side effects. We introduced these TCRs into T cells, pretreated tumor cells of different histological origins with the epigenetic drugs azacytidine and valproate, and tested tumor and self-reactivities of these TCRs. Pretreatment of tumor cells upregulated MC2 gene expression and enhanced recognition by T cells. In contrast, a panel of normal cell types did not express MC2 mRNA, and similar pretreatment did not result in recognition by MC2-directed T cells. Interestingly, the expression levels of MC2, but not those of CD80, CD86, or programmed death-ligand 1 or 2, correlated with T cell responsiveness. One of the tested TCRs consistently recognized pretreated MC2+ cell lines from melanoma, head and neck, bladder, and triple-negative breast cancers but showed no response to MHC-eluted peptides or peptides highly similar to MC2. We conclude that targeting MC2 Ag, combined with epigenetic drug-enhanced antigenicity, allows for significant and tumor-selective T cell responses.
The Encoplot Similarity Measure for Automatic Detection of Plagiarism - Notebook for PAN at CLEF 2011

This paper describes the evolution of our method Encoplot for automatic plagiarism detection and the results of the participation to the PAN’11 competition. The main novelties are the introduction of a new similarity measure and of a new ranking method, which cooperate to rank much better the source– suspicious document pairs when selecting the candidates for the detailed analysis phase. We have obtained excellent results in the competition, ranking 1 on the manually paraphrased cases, 2 overall in the external plagiarism detection task, and getting the best recall on the non-translated corpus.
Isolated Upper Extremity Posttransplant Lymphoproliferative Disorder in a Child

Posttransplant lymphoproliferative disorder (PTLD) is a well-described complication of solid organ and bone marrow transplants. The most common presentation is intra-abdominal lymphadenopathy or single or multiple intraparenchymal masses involving the liver, spleen, or kidneys. Here we describe the imaging and pathology findings of an unusual case of PTLD appearing as an intramuscular forearm lesion in a pediatric male. The manifestation of PTLD as an isolated upper extremity mass in a pediatric patient has to our knowledge not been described.
Differential Expression of Hyperhydricity Responsive Peach miRNAs

Hyperhydricity is a syndrome that causes morpho-physiological malformations in tissue culture plantlets. Micro-RNAs (miRNA) are small non-coding RNAs that play important regulatory roles in plant development, stress response, and adaptation to environmental conditions. In this study, differential expression analysis indicated that miRNAs play an underlying role in the responses to the hyperhydricity syndrome in peach Prunus persica (L.) leaves. 24 known and three novel potential miRNAs were characterized in hyperhydric and non-hyperhydric transcriptome libraries. The miRNA-target transcript analyses indicated that transport, plant cuticle development, intracellular part, and stress response are regulated by miRNAs in hyperhydric leaves. It is also suggested that miR5021 and miRnovel2 might play critical regulatory roles in hyperhydricity regarding miRNA-based response to stress. This study went one step further to advance understanding of molecular miRNA-based regulatory mechanisms regarding responses to hyperhydricity in peach.
Vehicle localization and navigation on region with disappeared lane line marking

Vehicle lane-level localization is a fundamental and key technology in the autonomous driving on structuring road. Structuring road can be divided into two categories: marked road and non-marked road. Nowadays, most of the vehicle localization methods are based on lane line marking, but vehicle localization based on a non-marking road is the key to achieving autonomous driving. This paper proposes a novel method based on stereo cameras, which combines particle filter to locate the vehicle and make the vehicle navigation on the region with disappeared lane line marking. The experimental results have shown that the system can real-timely work well.
Strategic Human Resources Management and its Impact on Performance : T he Case from Saudi Arabia

The aim of this study is to explore the adoption of Strategic Human Resources Management (SHRM) approach in banking organizations that operates in Abha city Sauid Arabia. It aims also to examine the relationship between Human Resource Management (HRM) and organizational performance, in addition, it aims to explore the main problems and challenges that may face (HRM) in the targeted banks. A survey methodology was adopted in this study through using the self-administrated standardized questionnaire as the data collection method and that was distributed to (50) managers and collected from (29) managers. The results of the study were as follows: the targeted banks adopt (SHRM) approach when managing their (HR) as they also have long-term (HR) plans and written (HR) plans and policies; (HRM) managers participate in top management meetings. The most prominent challenges that hinder the effective implementation of (SHRM) were: limited budget dedicated to (HR) activities; lack of cooperation and coordination between executive managers and (HR) managers. Training, initial test, compensation and rewards are the main (HRM) practices and activities in the targeted banks. Importantly, (SHRM) positively affect the organizational performance which can be represented by increasing profits, increasing the sales ratios, increasing job satisfaction and increasing the loyalty of employees. The current study has made significant contributions to the body of knowledge at academic and practical levels and has come up with good recommendations to improve management of (HRM) and (SHRM) which will affect the effectiveness of whole organization; they are presented in the final chapter of the dissertation.
A Study in Early Speech Development: A Preliminary Approach for Systematic Observation. (RIEEC Research Bulletin 4).

ABSTRACT A normal Japanese boy (11-months-old) was observed while playing alone and while interacting with his mother to study the child's physical ane. vocal imitation and to determine the relationship between his use of physical (nonverbal) and vocal (verbal) communication. During 10 freeplay sessions, four observers' noted occurrences of such behavior as spontineous physical contact with the mother, lack of response to the mother, and vocalizatlog_by the child-while he played alone. It was found that the child 1
Economically Inspired Self-healing Model for Multi-Agent Systems

Self-healing in fault tolerant multi-agent systems is the system ability to automatically detect, diagnose, and repair the faults. However, most of the available solutions are fragile in incomplete, uncertain, and dynamic situations. This paper proposes a novel economically inspired self-healing model for fault tolerant Multi-Agent Systems where the agents are self-interested autonomic elements collaborate to achieve fault tolerance as a given high-level objective of the system. It is an effective solution for dynamic situations with a high possibility of uncertainty. The proposed model is in fact toward responding the challenge of negotiation theory for autonomic systems introduced by IBM. In particular, it is an inspiration of general explanation of Communism, Socialism, and Capitalism. Extensive experiments illustrate the effectiveness of the proposed social approach in comparison to the cases of no help situation, using purely redundant components, and helping without using a social value.
Designing and testing fault-tolerant techniques for SRAM-based FPGAs

This paper discusses fault-tolerant techniques for SRAM-based FPGAs. These techniques can be based on circuit level modifications, with obvious modifications in the programmable architecture, or they can be implemented at the high-level description, without modification in the FPGA architecture. The high-level method presented in this work is based on Triple Modular Redundancy (TMR) and a combination of Duplication Modular Redundancy (DMR) with Concurrent Error Detection (CED) techniques, which are able to cope with upsets in the combinational and in the sequential logic. The methodology was validated by fault injection experiments in an emulation board. Results have been analyzed in terms of reliability, input and output pin count, area and power dissipation.
Rate Scaling Laws in Multicell Networks Under Distributed Power Control and User Scheduling

We analyze the sum rate performance in multicell single-hop networks where access points are allowed to cooperate in terms of a joint resource allocation. The resource allocation policies considered here combine power control and user scheduling. Although promising from a conceptual point of view, the optimization of the sum of per-link rates hinges on tough issues such as computational complexity and the requirement for heavy receiver-to-transmitter and cell-to-cell channel information feedback. In this paper, however, we show that simple distributed algorithms can scale optimally in terms of rates, when the number of users per cell U is allowed to grow large. We use extreme value theory to provide scaling laws for upper and lower bounds for the network sum-rate (sum of single user rates over all cells), corresponding to zero-interference and worst-case interference scenarios. We show that the scaling is either dominated by path loss statistics or by small-scale fading, depending on the regime and user location scenario. A surprising result is that the well known log log U rate behavior exhibited in i.i. d. fading channels with maximum rate schedulers is transformed into a log U behavior when path loss is accounted for. Additionally, by showing that upper and lower rate bounds behave in fact identically, asymptotically, our results suggest, remarkably, that the impact of multicell interference on the rate (in terms of scaling) actually vanishes asymptotically, when appropriate resource allocation policies are used.
An error in the mixed adversary protocol by Fitzi, Hirt and Maurer

We point out an error in the protocol for mixed adversaries and zero error from the Crypto 98 paper by Fitzi, Hirt and Maurer. We show that the protocol only works under a stronger requirement on the adversary than the one claimed. Hence the bound on the adversary's corruption capability given there is not tight. Subsequent work has shown, however, a new bound which is indeed tight.
One-step DNA melting in the RNA polymerase cleft opens the initiation bubble to form an unstable open complex

Though opening of the start site (+1) region of promoter DNA is required for transcription by RNA polymerase (RNAP), surprisingly little is known about how and when this occurs in the mechanism. Early events at the λPR promoter load this region of duplex DNA into the active site cleft of Escherichia coli RNAP, forming the closed, permanganate-unreactive intermediate I1. Conversion to the subsequent intermediate I2 overcomes a large enthalpic barrier. Is I2 open? Here we create a burst of I2 by rapidly destabilizing open complexes (RPo) with 1.1 M NaCl. Fast footprinting reveals that thymines at positions from -11 to +2 in I2 are permanganate-reactive, demonstrating that RNAP opens the entire initiation bubble in the cleft in a single step. Rates of decay of all observed thymine reactivities are the same as the I2 to I1 conversion rate determined by filter binding. In I2, permanganate reactivity of the +1 thymine on the template (t) strand is the same as the RPo control, whereas nontemplate (nt) thymines are significantly less reactive than in RPo. We propose that: (i) the +1(t) thymine is in the active site in I2; (ii) conversion of I2 to RPo repositions the nt strand in the cleft; and (iii) movements of the nt strand are coupled to the assembly and DNA binding of the downstream clamp and jaw that occurs after DNA opening and stabilizes RPo. We hypothesize that unstable open intermediates at the λPR promoter resemble the unstable, transcriptionally competent open complexes formed at ribosomal promoters.
Localization of a Binding Site for Herpes Simplex Virus Glycoprotein D on Herpesvirus Entry Mediator C by Using Antireceptor Monoclonal Antibodies

ABSTRACT The human herpesvirus entry mediator C (HveC), also known as the poliovirus receptor-related protein 1 (PRR1) and as nectin-1, allows the entry of herpes simplex virus type 1 (HSV-1) and HSV-2 into mammalian cells. The interaction of virus envelope glycoprotein D (gD) with such a receptor is an essential step in the process leading to membrane fusion. HveC is a member of the immunoglobulin (Ig) superfamily and contains three Ig-like domains in its extracellular portion. The gD binding site is located within the first Ig-like domain (V domain) of HveC. We generated a panel of monoclonal antibodies (MAbs) against the ectodomain of HveC. Eleven of these, which detect linear or conformational epitopes within the V domain, were used to map a gD binding site. They allowed the detection of HveC by enzyme-linked immunosorbent assay, Western blotting, and biosensor analysis or directly on the surface of HeLa cells and human neuroblastoma cell lines, as well as simian Vero cells. The anti-HveC V-domain MAbs CK6, CK8, and CK41, as well as the previously described MAb R1.302, blocked HSV entry. Their binding to soluble HveC was blocked by the association of gD with the receptor, indicating that their epitopes overlap a gD binding site. Competition assays on an optical biosensor showed that CK6 and CK8 (linear epitopes) inhibited the binding of CK41 and R1.302 (conformational epitopes) to HveC and vice versa. Epitope mapping showed that CK6 and CK8 bound between residues 80 and 104 of HveC, suggesting that part of the gD binding site colocalizes in the same region.
The Role of Comorbid Anxiety Symptoms in Children and Adolescents with Autism Spectrum Disorders (ASD) on an Emotional Perception Task

The focus of the present study is to investigate the relationship between anxiety symptoms and neural outcomes of emotion processing in children and adolescents with autism spectrum disorders (ASD) and neurotypical controls. Eighteen child and adolescent participants (9 ASD, 3 female) completed questionnaires, behavioral testing, and an fMRI scan. Participants with ASD demonstrated significantly higher scores on parent-reported anxiety measures than typically developing (TD) participants; however, observed amygdala activations were not related to parent-reported anxiety scores and OFC activation was not observed during emotional stimuli for either group. ASD and TD participants demonstrated significant bilateral responses in the superior temporal sulcus during emotional stimuli. The current study was unable to demonstrate potential functional neuropathology in the amygdala as a mechanism for apparent differential diagnostic patterns in ASDs. INDEX WORDS: Autism spectrum disorders, fMRI, Amygdala, Anxiety, Children, Emotion processing THE ROLE OF COMORBID ANXIETY SYMPTOMS IN CHILDREN AND ADOLESCENTS WITH AUTISM SPECTRUM DISORDERS (ASD) ON AN EMOTIONAL PERCEPTION TASK
Protein deprivation decreases male survival and the intensity of sexual antagonism in southern field crickets Gryllus bimaculatus

Recent theory predicts that the magnitude of sexual antagonism should depend on how well populations are adapted to their environment. We tested this idea experimentally by comparing intersexual genetic correlations for adult survival in pedigreed populations of southern field crickets (Gryllus bimaculatus) raised on naturally balanced (free‐choice) vs. imbalanced (protein‐deprived) diets. We tested for (1) sex differences in nutritional intake and preference, (2) sex‐specific effects of protein deprivation on survival and (3) diet dependence of the level of sexual antagonism. Adult males and females consumed a similar amount of protein, but protein deprivation decreased male survival but not female survival. Protein deprivation appeared to decrease the degree of sexual antagonism as intersexual genetic correlations were significantly lower than 1 only for the complementary free‐choice diet group but close to 1 for the protein‐deficient diet group. Our findings thereby implied that variation in nutritional environments can alter the magnitude of sexual antagonism. This research represents an important step towards understanding the relationship between sexual antagonism and adaptation in heterogeneous environments.