Miracle-dz/UniFAR-FTUs huggingface dataset:
Helmholtz-Zentrum Dresden-Rossendorf (HZDR) Chromatopanning for the identification of gallium binding peptides

This study is concerned with a chromatography-based approach (Immobilized Metal Ion Affinity Chromatography) for the recovery of gallium binding peptide sequences from a recombinant phage display library. The here described methods apply the fundamental knowledge and methods of separation science and meet thereby the key requirement of the phage display technique of precise separation of target-binding bacteriophage clones from non-interacting bacteriophage during the biopanning. During the chromatopanning called process, a total of 101 bacteriophage clones were identified of which in subsequent binding experiments, phage clones expressing the peptide sequences TMHHAAIAHPPH, SQALSTSRQDLR and HTQHIQSDDHLA were characterized to bind >10 fold better to a target that presents immobilized gallium ions than control phage, displaying no peptide sequence. The performance of biopanning experiments in chromatographic systems is particularly suitable for demanding targets such as trivalent metal ions. We found, that the selection AC CE PT ED M AN US CR IP T
Helmholtz-Zentrum Dresden-Rossendorf (HZDR) Scalable critical-path analysis and optimization guidance for hybrid MPI- CUDA applications

Utilizing accelerators in heterogeneous systems is an established approach for designing peta-scale applications. Today, CUDA offers a rich programming interface for GPU accelerators but requires developers to incorporate several layers of parallelism on both CPU and GPU. From this increasing program complexity emerges the need for sophisticated performance tools. This work contributes by analyzing hybrid MPI-CUDA programs for properties that are based on wait states such as the critical path, a metric proven to effectively identify application bottlenecks. We developed a tool which constructs a dependency graph based on an execution trace and the inherent dependencies of the programming models CUDA and MPI. Thereafter, it detects wait states and attributes blame to responsible activities. Together with the property of being on the critical path we can identify activities that are most viable for optimization. To evaluate the global impact of optimizations to critical activities we predict the program execution using a graph-based performance projection. The developed approach has been demonstrated with suitable examples to be both scalable and correct. Furthermore, we establish a new categorization of CUDA inefficiency patterns ensuing from the dependencies between CUDA activities.
Multisensor comparison of ice concentration estimates in the marginal ice zone

Aircraft remote sensing data collected during the 1984 summer Marginal Ice Zone Experiment in the Fram Strait are used to compare ice concentration estimates derived from synthetic aperture radar (SAR) imagery, passive microwave imagery at several frequencies, aerial photography, and spectral photometer data. The comparison is carried out not only to evaluate SAR performance against more established techniques but also to investigate how ice surface conditions, imaging geometry, and choice of algorithm parameters affect estimates made by each sensor. Active and passive microwave sensor estimates of ice concentration derived using similar algorithms show an rms difference of 13%. Agreement between each microwave sensor and near-simultaneous aerial photography is approximately the same (14%). The availability of high-resolution microwave imagery makes it possible to ascribe the discrepancies in the concentration estimates to variations in ice surface signatures in the scene.
Environmental Toxicology and Chemistry

The evaluation of adverse effects of pesticides, pesticide adjuvants, and their combination on honeybees is hampered by a lack of colony‐level bioassays reflecting productivity and survival over longer term exposure. In the present study, the joint toxicity of acetamiprid and co‐applied pesticide adjuvants (N‐methyl pyrrolidone [NMP], Silwet L‐77, and Triton X‐100) to honeybees was determined both in the laboratory and under semifield conditions. The 3 pesticide adjuvants caused no significant acute toxicity to honeybees by themselves; however, in the laboratory tests, they significantly increased the acute contact toxicity of acetamiprid to honeybees. For the semifield tests, in the T2 group (treatment with 5% acetamiprid soluble concentrate [SL] containing 10% Silwet L‐77), the mortality of honeybees was significantly higher (p< 0.05) than that of the blank control on the fourth day after application (DAA+ 4), that of the T1 group (5% acetamiprid SL containing 10% NMP) on DAA+ 4 and DAA+ 7 (seventh day after application), and that of the T3 group (5% acetamiprid SL containing 10% Triton X‐ 100) on DAA+ 4. Furthermore, the flight intensity in the T2 group on DAA+ 7, the colony intensity on DAA+ 28 (28th day after application), and the mean areas covered by pupae on DAA+ 15 (15th day after application) were significantly lower (p< 0.05) than those of the blank control. Therefore, pesticide adjuvants may be important factors in increasing the toxicity of neonicotinoids to honeybees. Measures should be taken to manage the environmental risk of pesticide adjuvants during the process of formulation development and registration. Environ Toxicol Chem 2019;38:1940–1946. © 2019 SETAC
Environmental Toxicology and Chemistry

Periphyton biofilms produce a substantial fraction of the overall monomethylmercury (MMHg) flux in East Fork Poplar Creek, an industrially contaminated, freshwater creek in Oak Ridge, Tennessee. We examined periphyton MMHg production across seasons, locations, and light conditions using mercury stable isotopes. Methylation and demethylation rate potentials (km, trans av and kd, trans av, respectively) were calculated using a transient availability kinetic model. Light exposure and season were significant predictors of km, trans av, with greater values in full light exposure and in the summer. Season, light exposure, and location were significant predictors of kd, trans av, which was highest in dark conditions, in the spring, and at the upstream location. Light exposure was the controlling factor for net MMHg production, with positive production for periphyton grown under full light exposure and net demethylation for periphyton grown in the dark. Ambient MMHg and km, trans av were significantly correlated. Transient availability rate potentials were 15 times higher for km and 9 times higher for kd compared to full availability rate potentials (km, full av and kd, full av) calculated at 1 d. No significant model for the prediction of km, full av or kd, full av could be constructed using light, season, and location. In addition, there were no significant differences among treatments for the full availability km, full av, kd, full av, or net MMHg calculated using the full availability rate potentials. km, full av was not correlated with ambient MMHg concentrations. The present results underscore the importance of applying transient availability kinetics to MMHg production data when estimating MMHg production potential and flux. Environ Toxicol Chem 2019;38:2426–2435. © 2019 SETAC
Development of a Failure Theory for Concrete

The failure behavior of concrete materials is not completely understood because conventional test methods fail to assess the material response independent of the sample size and shape. To study the influence of strength affecting test conditions, four typical concrete sample types were experimentally evaluated in uniaxial compression and analyzed for strength, crack initiation/propagation, and fracture patterns under varying boundary conditions. Both low friction and conventional compression interfaces were assessed. High-speed video technology was used to monitor macrocracking. Inferential data analysis proved reliably lower strength results for reduced surface friction at the compression interfaces, regardless of sample shape. Reciprocal comparisons revealed statistically significant strength differences between most sample shapes. Crack initiation and propagation was found to differ for dissimilar compression interfaces. The principal stress and strain distributions were analyzed, and the strain domain was found to resemble the experimental results, whereas the stress analysis failed to explain failure for reduced end confinement. Neither stresses nor strains indicated strength reductions due to reduced friction, and therefore, buckling was considered. The high-speed video analysis revealed buckling phenomena, regardless of end confinement. Slender elements were the result of low friction, and stocky fragments developed under conventional confinement. The critical buckling load increased accordingly. The research showed that current test methods do not reflect the ``true'' compressive strength and that concrete failure is strain driven. Ultimate collapse results from buckling preceded by unstable cracking.
Efektivní metody pro modelování a kvantifikaci medicínských rizik

Disertacni prace na tema Efektivni metody pro modelovani a kvantifikaci medicinských rizik ukazuje a v konkretnich připadech řesi metody a postupy k ziskani výsledků o zařazeni pacienta do jedne z několika kategorii Phadiatop testu, a to jen na zakladě detailniho studia osobni a rodinne anamnezy. Mimo jine poukazuje i na pochybeni, k nimž dochazi při sběru medicinských dat. Dale se zaměřuje na geneticke predispozice ke vzniku atopie a ukazuje ta onemocněni, ktera výsledek ovlivňuji. Vlastni prace obsahuje 8 kapitol. Uvodni cast (kapitola 2) je věnovana zakladnim teoretickým poznatkům o vzniku atopie, alergiich a Phadiatop testu. Z teto teorie je pak vychazeno při navrzich matematických postupů a modelovani výsledků zařazeni pacienta do konkretni skupiny Phadiatop testu. Těmi se zabývaji nasledujici dvě kapitoly. Kapitola 3 popisuje diskriminaci pomoci logisticke regrese a kapitola 4 je zaměřena na predikci do vice skupin pomoci multinomicke vysvětlovane proměnne. Tato je jestě rozdělena na možnosti predikce do neuspořadaných kategorii a uspořadaných kategorii. Kapitola 5 je věnovana obdrženým databazim, poznatkům o zaznamech a předzpracovani dat do použitelne statisticke podoby. Metodika popsana v kapitolach 3 a 4 je aplikovana na konkretni data v kapitolach 7 a 8. Představuje metody logisticke regrese pro zařazeni pacienta do skupiny „negativniho“ nebo „pozitivniho“ Phadiatop testu. Narocnějsim zpracovanim dane problematiky se zabýva kapitola 8, ktera pojednava o ordinalni regresi, tedy zařazeni pacienta do jedne z pěti konkretnich skupin Phadiatop testu podle zavažnosti. Kapitola 9 dava ucelený navod jak postupovat při využiti ordinalni regrese a ukazuje, jak tato predikce probiha na konkretnim přikladu. V kapitole 10 jsou uvedeny zavěry a doporuceni pro predikci pacientů do jednotlivých skupin Phadiatop testu. Pro zařazeni pacienta do konkretni skupiny Phadiatop testu byl vytvořen applet, který je připraven k využiti přimo na odborných pracovistich, tento je na přiloženem CD spolu s testovanou databazi pacientů. Strucným vyhodnocenim genetických predispozic ke vzniku atopie se zabýva kapitola 11.
Acoustic Detection of Greenhouse-induced Climate Changes in the Presence of Slow Fluctuations of the Thermohaline Circulation

Abstract Munk and Forbes have proposed to detect greenhouse gas-induced climate changes in the World Ocean with an array of long-range acoustic transmissions from Heard Island in the southern Indian Ocean. We estimated–assuming a continuously monitorable simplified axial ray propagation–the signal-to-noise ratio for such an experiment in an environment of slow fluctuations of the thermohaline circulation on a decadal time scale. The signal and noise are obtained from two coarse-resolution ocean general circulation model simulations. In the first, prescribed greenhouse atmospheric anomalies forced the ocean and yielded rough estimates of ocean response to greenhouse warming. In the second, some aspects of low-frequency internal variability of the ocean were obtained by stochastic forcing of the same ocean model. By this technique, no oscillations of the coupled ocean-atmosphere system Eke, for instance, El Nino-Southern Oscillation (ENSO) could be stimulated. Both signal and internal variability proved to .
Combining Novel Hormonal Therapies with a Poly (ADP-Ribose) Polymerase Inhibitor for Metastatic Castration-Resistant Prostate Cancer: Emerging Evidence

Preclinical and clinical studies have suggested potential synergies of combining poly (ADP-ribose) polymerase (PARP) inhibitors and novel hormonal therapies (NHT) for patients with metastatic castration-resistant prostate cancer (mCRPC). We systematically searched PubMed, ClinicalTrials.gov and ASCO-GU annual meeting abstracts up to March 2023 to identify potential phase III trials reporting the use of combining PARP inhibitors with NHT in the first-line setting for mCRPC. A total of four phase III trials met the criteria for subsequent review. Emerging data suggested that the radiographic progression-free survival (rPFS) was significantly longer in the PARP inhibitor combined with NHT group versus the placebo plus NHT group for the first-line setting of biomarker-unselected mCRPC patients, especially for patients with homologous recombination repair (HRR) mutation (HRR m), and with the greatest benefit for BRCA1/2 mutation (BRCA1/2 m) populations. Final overall survival (OS) data of the PROpel trial indicated a significant improvement in median OS for mCRPC patients with HRR m and BRCA1/2 m receiving olaparib + abiraterone. Prior taxane-based chemotherapy might not influence the efficacy of the combination. Compared with the current standard-of-care therapies, combining NHT with PARP inhibitors could achieve a significant survival benefit in the first-line setting for mCRPC patients with HRR and BRCA1/2 mutations.
Semantic Web: Revolutionizing Knowledge Discovery in the Life Sciences

This book introduces advanced semantic web technologies, illustrating their utility and highlighting their implementation in biological, medical, and clinical scenarios. It covers topics ranging from database, ontology, and visualization to semantic web services and workflows. The volume also details the factors impacting on the establishment of the semantic web in life science and the legal challenges that will impact on its proliferation.
Injection‐induced seismicity on basement faults including poroelastic stressing

Most significant induced earthquakes occur on faults within the basement beneath sedimentary cover. In this two‐dimensional plane strain numerical study, we examine the full poroelastic response of basement faults to fluid injection into overlying strata, considering both (1) the permeability of the fault zone and (2) the hydraulic connectivity of the faults to the target horizon. Given hydraulic and mechanical properties, we compute the spatiotemporal change in Coulomb stress, which we separate into (1) the change in poroelastic stresses Δτs+fΔσn, where Δτs and Δσn are changes in shear and normal stress (Δτs>0 and Δσn>0 both favor slip), and (2) the change in pore pressure fΔp. Pore pressure diffusion into hydraulically connected, permeable faults dominates their mechanical stability. For hydraulically isolated or low‐permeability faults, however, poroelastic stresses transmitted to deeper basement levels can trigger slip, even without elevated pore pressure. The seismicity rate on basement fault zones is predicted using the model of Dieterich (1994). High seismicity rates can occur on permeable, hydraulically connected faults due to direct pore pressure diffusion. Lower rates are predicted on isolated steeply dipping normal faults, caused solely by poroelastic stressing. In contrast, seismicity on similarly oriented reverse faults is inhibited.
LIS EDUCATION IN INDIA: A CHOROLOGICAL AND CHRONOLOGICAL STUDY

Though some reports suggest that in-service training of library personnel started first time in India in the beginning of 20th century, yet the LIS education as university course started quite late as compared to other disciplines in undivided India. Geographically distribution of LIS education centres in India presents an interesting feature. Calcutta, Baroda and Lahore (in undivided India) set the motion and then Andhra and others followed. 1940s and 1950s have been the turning point so far the progress of LIS education is concerned. Spread of LIS education has been so that during last one century more than 100 universities have been imparting LIS education with quite a few colleges offering LIS education too. The preset study makes an Endeavour to trace the chronology of development of and chorology of distribution of LIS education in India.
Carina Data Synthesis Project

The CARINA (CARbon dioxide IN the Atlantic Ocean) data synthesis project is an international collaborative effort of the EU IP CARBOOCEAN, and US partners. It has produced a merged internally consistent data set of open ocean subsurface measurements for biogeochemical investigations, in particular, studies involving the carbon system. The original focus area was the North Atlantic Ocean, but over time the geographic extent expanded and CARINA now includes data from the entire Atlantic, the Arctic Ocean, and the Southern Ocean. Carbon data from the Pacific Ocean are being synthesized in the PICES effort. The CARINA database includes data from 188 cruises. The salinity, oxygen, nutrient, inorganic carbon system and CFC data have been subjected to extensive quality control (QC) and adjustments have been made when necessary. The internally consistent data are available as three data products, one each for the Arctic Mediterranean Seas, the Atlantic and the Southern Oceans (CARINA Data Products). In addition, all of the individual cruise data files have been made available in WOCE exchange format in a single location (Cruise Summary Table) along with metadata and references. We strongly recommend users to employ the data products instead of the individual cruise files as the data in the latter have not been corrected for biases identified during the secondary QC. The CARINA effort is further described in the following as well as in the CARINA special issue of Earth System Science Data (ESSD) Journal. The CARINA database is available free of charge as a numeric data package (NDP) from the Carbon Dioxide Information Analysis Center (CDIAC). The NDP consists of the original oceanographic data files from 188 cruises, three data products and this documentation, which describes the CARINA project.
Erosion and Sediment Control

Permit / Renewal Fee Receipt No. Security Deposit Receipt No. Personal information on this form is collected under the authority of the Erosion & Sediment Control By-law 512-91, as amended by By-law 394-93. The personal information will be used for processing and administering your application. Questions about this collection should be directed to the Manager of Stormwater Projects & Approvals, 201 City Centre Drive, Suite 800, Mississauga, ON L5B 2T4 , Tel. 905-615-3200 ext. 5161.
Perception of Risk Posed by Extreme Events

Extreme events, by definition, cause much harm to people, property, and the natural world. Sometimes they result from the vagaries of nature, as in the case of flood, earthquake, or storm, and thus are truly the outcomes of "games against nature. " In other cases they follow technological failure or unintentional human error, as in the case of Chernobyl or Bhopal, putting them also into the category of risks that are predictable only probabilistically. More recently we have witnessed another form of extreme hazard, resulting from terrorism. One of us has termed this "a new species of trouble" (Slovic, in press), since it involves an intelligent and motivated opponent, putting the situations that give rise to these types of extreme events into the domain of economic game theory. The purpose of this brief review is to examine what existing research can tell us about the perception of risk associated with these extreme events. We will also point out issues that remain in need of exploration.
Rupture of the 4 February 1976 Guatemalan earthquake

Abstract An expanded body-wave data set for the 4 February 1976 Guatemalan earthquake is analyzed by iterative, multiple-station inversion to provide enhanced resolution of the rupture process of this important strike-slip event. The body-wave data set used in an earlier study of this event, in which a predominantly unilateral, westward-propagating rupture was proposed, actually does not have sufficient resolution to reliably map the spatial heterogeneity for the source process. The expanded azimuthal coverage of the new data set provides better spatial resolution of the primary rupture characteristics. The Guatemalan earthquake can be modeled as an asymmetric bilateral rupture extending eastward and westward along the Motagua fault, with the largest episode of moment release occurring ≈90 km west of the epicenter, near a change in strike in the surface faulting. The overall rupture velocity is about 3.5 km/sec, and the total moment is 3.7 × 10 27 dyne cm. Inversions with composite fault models having a second focal mechanism appropriate for the western end of the fault are consistent with the data, but are not clearly required. The characterization of the Guatemalan earthquake as an irregular bilateral rupture agrees with the variable co-seismic surface displacements measured along the fault outcrop as well as with an earlier surface-wave investigation, and is consistent, in a general sense, with previous characterizations of the irregular rupture processes of other large strike-slip earthquakes such as the 1972 Sitka, Alaska and the 1980 Eureka, California events.
Evaluation of Wayfinding Aids in Virtual Environment

It is difficult for a navigator to find directions to a given target in an unfamiliar environment, especially a virtual environment. The commonly used overview maps can show survey knowledge only on one particular scale but cannot provide spatial knowledge at other scales. In this study, three wayfinding aids (a view-in-view map, animation guide, and human system collaboration) were compared experimentally in terms of effectiveness, efficiency, and users' satisfaction. Results show that although these three aids all can effectively help participants find targets quicker and easier, their usefulness is different, with the view-in-view map being the best and human system collaboration the worst. Their usefulness also appears to be different for people with different spatial abilities. The results indicate that the design of wayfinding tools in virtual environments should consider the type and the presentation style of spatial information based on wayfinding tasks and users' spatial ability.
Seismic data interpolation using plane-wave shaping regularization

The problem with interpolating insufficient, irregularly sampled data is that there exist infinitely many solutions. When solving ill-posed inverse problems in geophysics, we apply regularization to constrain the model space in some way. We propose to use plane-wave shaping in iterative regularization schemes. By shaping locally planar events to the local slope, we effectively interpolate in the structure-oriented direction and preserve the most geologic dip information. In our experiments, this type of interpolation converges in fewer iterations than alternative techniques. The proposed plane-wave shaping mave have potential applications in seismic tomography and well-log interpolation.
Markov Chain Monte Carlo and Variational Inference: Bridging the Gap

Recent advances in stochastic gradient variational inference have made it possible to perform variational Bayesian inference with posterior approximations containing auxiliary random variables. This enables us to explore a new synthesis of variational inference and Monte Carlo methods where we incorporate one or more steps of MCMC into our variational approximation. We describe the theoretical foundations that make this possible and show some promising ﬁrst results