Miracle-dz/UniFAR-FTUs huggingface dataset:
AutoModelGen: A Generic Data Level Implementation of ModelGen

The model management operator ModelGen translates a schema expressed in one modelling language into an equivalent schema expressed in another modelling language, and in addition produces a mapping between those two schemas. AutoModelGen is a generic data level implementation of ModelGen that meets these desiderata. Our approach is distinctive in that (i) it takes a generic approach that can be applied to any modelling language, and (ii) it does not rely on knowing the modelling language in which the source schema is expressed in.
InproTKs: A Toolkit for Incremental Situated Processing

In order to process incremental situated dialogue, it is necessary to accept information from various sensors, each tracking, in real-time, different aspects of the physical situation. We present extensions of the incremental processing toolkit INPROTK which make it possible to plug in such multimodal sensors and to achieve situated, real-time dialogue. We also describe a new module which enables the use in INPROTK of the Google Web Speech API, which offers speech recognition with a very large vocabulary and a wide choice of languages. We illustrate the use of these extensions with a description of two systems handling different situated settings.
Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle

ABSTRACT Little is known about the quantitative contributions of nonhomologous end joining (NHEJ) and homologous recombination (HR) to DNA double-strand break (DSB) repair in different cell cycle phases after physiologically relevant doses of ionizing radiation. Using immunofluorescence detection of γ-H2AX nuclear foci as a novel approach for monitoring the repair of DSBs, we show here that NHEJ-defective hamster cells (CHO mutant V3 cells) have strongly reduced repair in all cell cycle phases after 1 Gy of irradiation. In contrast, HR-defective CHO irs1SF cells have a minor repair defect in G1, greater impairment in S, and a substantial defect in late S/G2. Furthermore, the radiosensitivity of irs1SF cells is slight in G1 but dramatically higher in late S/G2, while V3 cells show high sensitivity throughout the cell cycle. These findings show that NHEJ is important in all cell cycle phases, while HR is particularly important in late S/G2, where both pathways contribute to repair and radioresistance. In contrast to DSBs produced by ionizing radiation, DSBs produced by the replication inhibitor aphidicolin are repaired entirely by HR. irs1SF, but not V3, cells show hypersensitivity to aphidicolin treatment. These data provide the first evaluation of the cell cycle-specific contributions of NHEJ and HR to the repair of radiation-induced versus replication-associated DSBs.
Short-term Resistance and Plyometric Training Improves Eccentric Phase Kinetics in Jumping

Abstract Kijowksi, KN, Capps, CR, Goodman, CL, Erickson, TM, Knorr, DP, Triplett, NT, Awelewa, OO, and McBride, JM. Short-term resistance and plyometric training improves eccentric phase kinetics in jumping. J Strength Cond Res 29(8): 2186–2196, 2015—The purpose of this investigation was to examine the effect of an abbreviated resistance and plyometric training program on force- and power-time curve variables during jumping. Nineteen male subjects were assigned to either a training (n = 9) or control group (n = 10). Training consisted of performing 3 sets of 3 repetition squats (90% of 1 repetition maximum [RM]) and 5 sets of 6 repetition drop jumps from 40 cm twice per week for 4 weeks. A 1RM in the squat and countermovement (CMJ) and static jump (SJ) performance was assessed before and after training. Several variables were analyzed for individual subject force- and power-time curves for the jumps. Average force- and power-time curves for all subjects combined were also analyzed. Absolute and relative squat strength significantly increased in training group (p ⩽ 0.05). Calculation of variables from individual subject force-time curves during the CMJ indicated a significant decrease in eccentric time, minimum force, and eccentric impulse and significant increase in eccentric rate of force development in training group. Analysis of individual power-time curves in the CMJ also revealed a significant decrease in minimum power and eccentric work and a significant increase in eccentric rate of power development. No significant changes occurred in the variables measured for the SJ. The results of this study indicate that short-term strength and plyometric training may preferentially influence eccentric performance variables during jumping in comparison with longer term training enhancements to the concentric phase performance.
“Motion-Resistant” Pulse Oximetry: A Comparison of New and Old Models

Several pulse oximeter manufacturers have recently developed instruments that are claimed to be resistant to the effects of patient motion. We performed a laboratory volunteer experiment to compare the performances of several of these instruments, as well as some older models, during combinations of motion and hypoxemia. Twenty oximeters were studied. A motorized table produced different hand motions, and each motion was studied during both room air breathing and hypoxemia. Pulse oximeters on the nonmoving hand were used to provide control measurements for comparison. The Masimo SET® pulse oximeter exhibited the best overall performance, with a performance index (percentage of time in which the Spo2 reading is within 7% of control value) of 94%. The Agilent Viridia 24C was next, with an 84% index, followed by the Agilent CMS (80%), the Datex-Ohmeda 3740 (80%), and the Nellcor N-395 (69%). For comparison with older oximeter technology, the Criticare 5040 had an index of 28%. Recent technology changes have significantly improved pulse oximeter performance during motion artifact, with the Masimo oximeter leading the way.
Multi-ultrasonic sensor fusion for autonomous mobile robots

Specular reflections from environments cause uncertainties to ultrasonic sensor range data. In this paper, we examine the application of evidential method for data integration using the specially designed sensor model to overcome the problem. Dempster's rule of combination is used to fuse the sensor data to obtain the map defined on a 2D evidence grid. The sensor model tries to reduce the uncertainties caused by specular reflections with a filtering factor. Experimental results have shown the usefulness of this method.
Removal of Polysialic Acid Triggers Dispersion of Subventricularly Derived Neuroblasts into SurroundingCNS Tissues

Cells generated in the subventricular zone give rise to neuroblasts that migrate to the olfactory bulb (OB) along the rostral migratory stream (RMS). The polysialylated form of neural cell adhesion molecule (PSA-NCAM) is expressed by these cells, and has been shown to both promote their migration and suppress differentiation induced by NCAM. In the present study, enzymatic removal of PSA from these neuroblasts using PSA-specific endoneuraminidase has been found not only to disrupt the tangential migration and cellular organization of the RMS, but also to cause a massive dispersion of BrdU (5-bromo-2′-deoxyuridine)-labeled neuroblasts into surrounding brain regions, including cortex and striatum. These dispersed cells are capable of differentiation, some into mature neurons, and could potentially be of value in the repair of CNS injury. Although the removal of PSA by genetic deletion of NCAM also results in a smaller OB and a swollen RMS, the cells do not escape the RMS in large numbers. These findings suggest that the presence of NCAM without PSA plays a role in the dispersion process, possibly by inducing a new pattern of migration associated with NCAM-dependent differentiation.
Patterns of grandparental child care across Europe: the role of the policy context and working mothers' need

ABSTRACT Across Europe grandparents play very different roles. This paper studies to what extent grandparents' role as providers of child care relates to the country policy context, focusing on public child-care services and parental leave regulation, and to the availability of part-time jobs for women. We also explore whether mothers' needs to combine family and work differently influence the frequency of grandparental child care across countries. The analysis combines micro-data from the Survey of Health, Ageing and Retirement in Europe and macro-indicators from the Multilinks database and Eurostat. We find a clear association between policy context and frequency of grandparental child care. Three models emerge. In countries close to the familialism by default model (i.e. characterised by scarce public child-care services and parental leave), when grandparents provide child care they often do it daily. In countries characterised by defamilialisation and supported familialism policies (with generous public services and parental leave) grandparents take on a marginal role. An intermediate model emerges in countries characterised by a limited offer of child care or parental leave, where grandparental child care complements state support and tends to be offered on a weekly basis. Our analysis corroborates the idea that the highly intensive involvement of grandparents in countries with low availability of part-time jobs for women is influenced by the need (unmet by the welfare) of mothers to combine work and family.
Limited axial structures in nodeless chick blastoderms.

The author has been using post-nodal segments of early chick blastoderms as an experimental system to study early morphogenesis and differentiation. The segment is produced by a transverse cut at about 0·4 mm from the primitive pit and is known for its very limited potencies in chorio-allantoic transplantation or in culture, in contrast to anterior parts containing Hensen9s node (Hunt, 1931; Willier & Rawles, 1931; Rudnick, 1938; Waddington, 1933; Spratt, 1952; Butros, 1962). One of its characteristic features is the appearance of a concavity in the middle of the anterior border in the shape of a “V” (Waddington, 1935; Rudnick, 1938), but it is not established whether this is due to regression movements of the primitive streak or to retraction of lateral parts (Jacobson, 1938). Experiments attempting to clarify this point are reported in this paper. Another feature noted upon explanting the post-nodal segment is the accumulation of mesoderm in the midline, forming columns that seem to supplement the primitive streak gradually.
Affective Disorders and Organic Mental Disorders

Depression in old patients can be isolated or associated with dementia. In the first instance signs and symptoms sometimes mimic a demented state: disinterest, lack of initiative, mnesic complaints, slowing of thinking, learning difficulties. The EEG and the CT scan are useful in differential diagnosis, the value of the neuropsychological evaluation being compromised by lack of cooperation. In the second case the consequences of depression vary according to degree of severity of the dementia. In mild cases it can transitorily increase memory disturbances. In moderate and severe levels we see more regressive behavior. Sometimes we must wait for the therapeutic effects of antidepressant medication before we can establish the diagnosis with finality. The diagnosis of “pseudo-dementia” is only a provisional concept.
Topical negative pressure wound therapy: a review of its role and guidelines for its use in the management of acute wounds

Over the past two decades, topical negative pressure (TNP) wound therapy has gained wide acceptance as a genuine strategy in the treatment algorithm for a wide variety of acute and chronic wounds. Although extensive experimental and clinical evidence exists to support its use and despite the recent emergence of randomised control trials, its role and indications have yet to be fully determined. This article provides a qualitative overview of the published literature appertaining to the use of TNP therapy in the management of acute wounds by an international panel of experts using standard methods of appraisal. Particular focus is applied to the use of TNP for the open abdomen, sternal wounds, lower limb trauma, burns and tissue coverage with grafts and dermal substitutes. We provide evidence‐based recommendations for indications and techniques in TNP wound therapy and, where studies are insufficient, consensus on best practice.
Characterization of the Ah receptor and aryl hydrocarbon hydroxylase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and benz(a)anthracene in the human A431 squamous cell carcinoma line.

Certain human cell lines previously have been shown to exhibit substantial induction of aryl hydrocarbon hydroxylase (AHH, cytochrome P450IA1) when treated in culture with aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or benz(a)anthracene. Yet the Ah receptor, which is known to mediate the AHH induction process in rodent cells and tissues, has not previously appeared to be present at a significant level in any human cell line. In the human A431 squamous cell carcinoma line we found that cytosolic Ah receptor was present in high concentration (approximately 200 fmol/mg cytosol protein at maximal saturation); this corresponds to approximately 10,000 Ah receptor sites per cell in the human A431 line compared with about 35,000 receptor sites per cell in the mouse Hepa-1 hepatoma cell line in which Ah receptor previously has been extensively characterized. Detection of Ah receptor in A431 cytosol required modification of assay techniques, especially reduction in the amount of charcoal used to adsorb nonspecifically bound radioligand. The specific binding peak from A431 cytosol sedimented approximately 9S on sucrose gradients, the same as the cytosolic receptor from the well-characterized mouse Hepa-1 hepatoma cell line. In addition to [3H]TCDD, specific binding to Ah receptor in A431 cytosol also was detected with [3H]3-methylcholanthrene and with [3H]benzo(a)pyrene as radioligands. A specific [3H]TCDD-Ah receptor complex was extracted from nuclei of A431 cells incubated in culture at 37 degrees C with [3H]TCDD. The nuclear form of Ah receptor sedimented approximately 5S, the same as the nuclear receptor from mouse Hepa-1 cells. AHH activity was induced in A431 cells treated in culture with TCDD or benz(a)anthracene. The maximum level of induced AHH activity that could be achieved in A431 cells was about 20% of the maximally induced level in the mouse Hepa-1 cell line. However, the dose-response curves for AHH induction by TCDD or benz(alpha)anthracene in A431 cells were shifted about one log unit to the right of the curves for Hepa-1 cells. The lower sensitivity of A431 cells to AHH inducers was in proportion to the lower affinity with which cytosolic Ah receptor in A431 cells bound [3H]TCDD. The saturation curve for binding of [3H]TCDD to cytosolic Ah receptor in A431 cells also was shifted about one log unit to the right of the curve for saturation of the cytosolic receptor from mouse Hepa-1 cells. (ABSTRACT TRUNCATED AT 400 WORDS)
Sample-Based Attribute Selective A$n$ DE for Large Data

More and more applications have come with large data sets in the past decade. However, existing algorithms cannot guarantee to scale well on large data. Averaged n-Dependence Estimators (AnDE) allows for flexible learning from out-of-core data, by varying the value of n (number of super parents). Hence, AnDE is especially appropriate for large data learning. In this paper, we propose a sample-based attribute selection technique for AnDE. It needs one more pass through the training data, in which a multitude of approximate AnDE models are built and efficiently assessed by leave-one-out cross validation. The use of a sample reduces the training time. Experiments on 15 large data sets demonstrate that the proposed technique significantly reduces AnDE's error at the cost of a modest increase in training time. This efficient and scalable out-of-core approach delivers superior or comparable performance to typical in-core Bayesian network classifiers.
Migration of a sphere in tube flow

The cross-stream migration of a single neutrally buoyant rigid sphere in tube flow is simulated by two packages, one (ALE) based on a moving and adaptive grid and another (DLM) using distributed Lagrange multipliers on a fixed grid. The two packages give results in good agreement with each other and with experiments. A lift law $L \,{=}\, CU_s (\Omega_s-\Omega_{\hbox{\scriptsize{\it se}}})$ analogous to $L \,{=}\, \rho U\Gamma$ which was proposed and validated in two dimensions is validated in three dimensions here; $C$ is a constant depending on material and geometric parameters, $U_s$ is the slip velocity and it is positive, $\Omega_s$ is the slip angular velocity and $\Omega_{\hbox{\scriptsize{\it se}}}$ is the slip angular velocity when the sphere is in equilibrium at the Segré–Silberberg radius. The slip angular velocity discrepancy $\Omega_s-\Omega_{\hbox{\scriptsize{\it se}}acute;$ is the circulation for the free particle and it changes sign with the lift. A method of constrained simulation is used to generate data which is processed for correlation formulas for the lift force, slip velocity, and equilibrium position. Our formulae predict the change of sign of the lift force which is necessary in the Segré–Silberberg effect. Our correlation formula is compared with analytical lift formulae in the literature and with the results of two-dimensional simulations. Our work establishes a general procedure for obtaining correlation formulae from numerical experiments. This procedure forms a link between numerical simulation and engineering practice.
COLONY STRUCTURE OF A SLAVEMAKING ANT. II. FREQUENCY OF SLAVE RAIDS AND IMPACT ON THE HOST POPULATION

Abstract The parasite pressure exerted by the slavemaker ant Protomognathus americanus on its host species Leptothorax longispinosus was analyzed demographically and genetically. The origin of slaves found in colonies of the obligate slavemaker was examined with nuclear and mitochondrial DNA markers to make inferences about the frequency and severity of slave raids. Relatedness of enslaved L. longispinosus workers in the same nest was very low, and our data suggest that, on average, each slavemaker nest raids six host colonies per season. Therefore, the influence of slavemaker species on their hosts is much stronger than simple numerical ratios suggest. We also found that slave relatedness was higher in small than in large slavemaker nests; thus, larger nests wield a much stronger influence on the host. We estimated that in the study population, on average, a host nest has a 50% chance of being attacked by a slavemaker colony per year. Free-living Leptothorax colonies in the vicinity of slavemaker nests did not represent the source of slaves working in P. americanus colonies, which suggests that raided nests either do not survive or migrate after being raided. Colony composition and intranest relatedness of free-living L. longispinosus colonies differed markedly between areas with slavemakers and those that are parasite-free. In the presence of slavemakers, host colonies were less likely to be polygynous and had fewer workers and a higher relatedness among worker brood. Host nests with slavemaker neighbors allocated more resources into sexuals, possibly caused by these shifts in nest demography. Finally, enslaved Leptothorax workers in P. americanus nests appeared to be less efficient than their counterparts in free-living colonies. Thus, slavemakers exert a much stronger impact on their hosts than had previously been suspected and represent an unique system to study parasite-host coevolution.
From Linguistics to Ontologies - The Role of Named Entities in the Conceptualisation Process

Ontologies that have been built from texts can be associated with lexical information that is crucial for the semantic annotation of texts and all semantic search tasks. However, the entire pocess of building ontologies from texts cannot be fully automated and it is important to guide the knowledge engineer during the building process. This paper presents an enriched version of TERMINAE, which is a text-based methodology for ontology design. It combines a fact-based approach of modeling with the more traditional concept-centric one. We show that named entities can be used to enrich an existing ontology and to bootstrap the acquisition process. In other words, named entities are used for the conceptualisation of ontologies and not only for their population. This approach is illustrated on two use-cases based on policy documents and evaluated by measuring the Precision and Recall of the resulting ontologies with respect to pre-existing ontologies independently built by domain experts.
Reflection Invariance: an important consideration of image orientation

In this position paper, we consider the state of computer vision research with respect to invariance to the horizontal orientation of an image -- what we term reflection invariance. We describe why we consider reflection invariance to be an important property and provide evidence where the absence of this invariance produces surprising inconsistencies in state-of-the-art systems. We demonstrate inconsistencies in methods of object detection and scene classification when they are presented with images and the horizontal mirror of those images. Finally, we examine where some of the invariance is exhibited in feature detection and descriptors, and make a case for future consideration of reflection invariance as a measure of quality in computer vision algorithms.
Towards Constructing Linguistic Ontologies: Mapping Framework and Preliminary Experimental Analysis

Cross-language ontology matching methods leverage translation based approach in mapping ontological resources (e.g., concepts) lexicalized in different languages. Such methods are largely dependent on the structural information encoded in the matched ontologies. The paper presents an approach for large scale cross-language linguistic ontology matching. In particular, it shows how synsets belonging to two distinct language wordnets can be mapped, by means of machine translation and frequency analysis on word senses. A preliminary experimental analysis of the problem is presented, through which we conduct experiments on existing gold-standard datasets. The results are encouraging and show the feasibility of the approach and demonstrate that the sense-selection task is a crucial step towards high quality mappings. We conclude with our observations and draw our potential future directions.