Miracle-dz/UniFAR-FTUs huggingface dataset:
The Role of Injectables in the Treatment and Prevention of Cancer-Associated Thrombosis

Simple Summary People with cancer are at an increased risk of developing blood clots. Both cancer and anti-cancer treatment are responsible for this risk. In some types of cancer, such risk is higher than in others. There are different types of blood thinners also known as anticoagulants. Blood thinners prevent the recurrence of deep venous thrombosis (a blood clot in the limbs) or pulmonary embolism (a blood clot in the lungs) in people with cancer. In some clinical situations and, specifically, in patients with active cancer, injectable blood thinners are safer than tablets to be taken orally and work just as well. Abstract Cancer-associated thrombosis (CAT) is a leading cause of death among patients with cancer. CAT can manifest itself as venous thromboembolism (VTE), in the form of deep vein thrombosis or pulmonary embolism, or arterial thromboembolism. The pathophysiology of CAT is complex and depends on cancer-, patient-, treatment- and biomarkers-related factors. Treatment of VTE in patients with cancer is complex and includes three major classes of anticoagulant agents: heparin and its derivatives, e.g., low molecular weight heparins, direct oral anticoagulants (DOACs), and vitamin K inhibitors. Given the tremendous heterogeneity of clinical situations in patients with cancer and the challenges of CAT, there is no single universal treatment option for patients suffering from or at risk of CAT. Initial studies suggested that patients seemed to prefer an anticoagulant that would not interfere with their cancer treatment, suggesting the primacy of cancer over VTE, and favoring efficacy and safety over convenience of route of administration. Recent studies show that when the efficacy and safety aspects are similar, patients prefer the oral route of administration. Despite this, injectables are a valid option for many patients with cancer.
Doctors Fact-Check, Journalists Get Fact-Checked: Comparing Public Trust in Journalism and Healthcare

Public trust in journalism has fallen disconcertingly low. This study sets out to understand the news industry’s credibility crisis by comparing public perceptions of journalism with public perceptions of another institution facing similar trust challenges: healthcare. Drawing on in-depth interviews with 31 US adults, we find that although both healthcare and journalism face public distrust, members of the public generally tend to feel more trusting of individual doctors than they do of individual journalists. This is because people (a) perceive doctors to be experts in their field and (b) engage more frequently with doctors than they do with journalists. Consequently, our interviewees described treating their doctors as “fact-checkers” when it comes to health information they find online, demonstrating trust in their physicians despite their lack of trust in healthcare more broadly. Meanwhile, the opposite unfolds in journalism: Instead of using legitimate news sources to fact-check potential misinformation, people feel compelled to “fact-check” legitimate news by seeking alternative sources of corroboration. We conclude that, to improve their credibility among the public, journalists must strike the right balance between persuading the public to perceive them as experts while also pursuing opportunities to engage with the public as peers.
PHYTOMORPHOLOGY OF WHEAT AND ITS GRAIN QUALITY RESPONSE TO DIVERSE APPROACHES OF IRON APPLICATION

Agriculture soils of Pakistan are already deficient of macronutrients, and now inadequacy for micronutrients has also been reported causing adverse effects on crop productivity. The study was carried out to investigate the effect of soil and foliar applied iron (Fe) on wheat. The treatments included: T1=Control (without Fe), T2=Soil applied Fe 3 kg ha‑1, T3=Soil applied Fe 6 kg ha‑1, T4=Foliar applied Fe 0.2%, T5=Foliar applied Fe 0.4%, T6=Soil applied Fe 1.5 kg ha-1+foliar applied Fe 0.1%, T7=Soil applied Fe 1.5 kg ha-1+foliar applied Fe 0.2%, T8=Soil applied Fe 3 kg ha-1+foliar applied Fe 0.1% and T9=Soil applied Fe 3 kg ha-1+foliar applied Fe 0.2%. All the treatments as alone or in combination, affected growth, yield and quality of wheat significantly (P<0.05). The results showed that T9 and T3 were most promising for almost all studied traits. Under T9 and T3, variety “TD-1” produced plants of 59.44 and 59.09 cm, while “Sindhu” showed 92.9 and 75.98 cm height, respectively. Higher grain yield (4799.7 and 4760.5 kg ha-1), grain protein (17.22 and 17.13%) were also recorded in T9 and T3, respectively; while T1 remained the least. In varieties, “TD-1” produced higher grain yield (4788.9 kg) than “Sindhu” (4341.8 kg ha-1). Inversely, grain protein was higher in variety “Sindhu” (17.10%) than “ TD-1” (16.72%). It was concluded that soil applied Fe 3 kg ha-1+foliar Fe 0.2% concentration or in absence of foliar application, soil applied Fe at 6 kg ha-1 remained most appropriate dose for wheat growers in addition to recommended NPK
Comparison of quality results between semi-autoanalyzer and autoanalyzer: A retrospective study conducted in a tertiary care center (Rural India)

Introduction and Aim: In India, the primary health centres, urban health centres and privatized small-scale laboratories use basic laboratory services like point of care testing (POCT) and quantitative results obtained from semi-auto analysers for diagnosis and treatment. Our objectives were to analyse biochemical parameters in the autoanalyzer and the semi-autoanalyzer and to compare the test performance of analysed biochemical parameters in the semi-autoanalyzer and autoanalyzer. Materials and Methods: One hundred samples (10 patient samples and 90 internal quality control values), tested for 15 biochemical parameters were retrospectively studied. They were processed with the same reagent, methodology and environmental conditions in autoanalyzer Mindray BS 390 and semi-autoanalyzer KLS BA 200. Statistical analysis was carried out using independent student t test, Pearson correlation, Bias percent and Bland-Altman plot analysis Results: Our study showed strong positive correlation for the 15 biochemical parameters between semi-autoanalyzer and autoanalyzer except for calcium, which showed moderate positive correlation (r=0.879). Bias % were all in acceptable limits except for SGOT and Albumin. Bland Altman analysis for ALP and Triglycerides also showed high variability between the two measurements with a mean difference of -6.23 and 4.48 respectively. Conclusion: The test performance of biochemical parameters measured in the semi-auto analyser and fully automatic analyser were highly related and comparable, with a significant positive correlation. Semi-auto analysers could be an efficient alternative in peripheral setups to provide quality laboratory services. During the breakdown of any autoanalyzer, the semi-autoanalyzer acts as backup for analysing routine chemistry tests in some laboratories.
Unilateral cleft lip repair treatment outcomes using triangular flap and rotation-advancement techniques: A systematic review

Introduction: Cleft lip and palate is a common congenital facial malformation that significantly impacts deve­ lopmental, physical, and psychological aspects of patients and their families. It is essential to measure treatment outcomes in cleft surgery to evaluate cleft management in the era of evidence­based medicine. Objectives: This review aimed to analyze and compare outcomes of two primary unilateral cleft lip repair tech­ niques, such as triangular flap and rotation­advancement. Material and methods: Articles were retrieved from PubMed, Medline, Cochrane Library, and ScienceDirect based on PRISMA guidelines, to find relevant articles published between 1990­2021. Two reviewers independent­ ly appraised articles in separate rounds. A total of 1,241 articles were retrieved. However, only eight studies were selected based on inclusion criteria. Results: The rotation­advancement technique group showed better results in the shape of nostril and the length of Cupid’s bow, but with a higher finding of notching and nasal deformities. Meanwhile, the triangular flap tech­ nique group showed better results in philtral height, Cupid’s bow shape, vermilion height, lip height, and nasal width, despite having a more significant number of nasal defect formations compared with the rotation group. Conclusions: The triangular flap and rotation­advancement techniques have their respective advantages and dis­ advantages. Nevertheless, post­operative deformities can be found in some cases, including asymmetry of Cupid’s bow, flattened philtrum, elongated white lip, tilted columella, and flattened ala nasi. Further systematic review studies should be conducted to analyze treatment outcomes of primary cleft lip surgery in other techniques, ac­ cording to various measurement methods.
Review of Non-Eosinophilic Esophagitis-Eosinophilic Gastrointestinal Disease (Non-EoE-EGID) and a Case Series of Twenty-Eight Affected Patients

Eosinophilic gastrointestinal disease (EGID) is divided into eosinophilic esophagitis (EoE) and non-eosinophilic esophagitis eosinophilic gastrointestinal disease (non-EoE-EGID) based on the involved gastrointestinal segments. Reports regarding non-EoE-EGID are limited, in part because of its rarity. The present study was performed to review non-EoE-EGID, including its pathogenesis, diagnosis, treatment, and prognosis. Additionally, details regarding 28 cases of non-EoE-EGID recently diagnosed at our Japanese tertial medical center are presented and compared with 20 EoE cases diagnosed during the same period at the same medical center. Comparisons of the two groups clarified differences regarding age- and gender-dependent prevalence between the two conditions, and also showed that systemic involvement and disease severity were greater in the non-EoE-EGID patients. Notably, diagnosis of non-EoE-EGID is difficult because of its lack of specific or characteristic symptoms and endoscopic findings. The clinical characteristics of EoE and non-EoE-EGID differ in many ways, while they also share several genetic, clinical, laboratory, and histopathological features.
Chirality Matters: Fine-Tuning of Novel Monoamine Reuptake Inhibitors Selectivity through Manipulation of Stereochemistry

The high structural similarity, especially in transmembrane regions, of dopamine, norepinephrine, and serotonin transporters, as well as the lack of all crystal structures of human isoforms, make the specific targeting of individual transporters rather challenging. Ligand design itself is also rather limited, as many chemists, fully aware of the synthetic and analytical challenges, tend to modify lead compounds in a way that reduces the number of chiral centers and hence limits the potential chemical space of synthetic ligands. We have previously shown that increasing molecular complexity by introducing additional chiral centers ultimately leads to more selective and potent dopamine reuptake inhibitors. Herein, we significantly extend our structure-activity relationship of dopamine transporter-selective ligands and further demonstrate how stereoisomers of defined absolute configuration may fine-tune and direct the activity towards distinct targets. From the pool of active compounds, using the examples of stereoisomers 7h and 8h, we further showcase how in vitro activity significantly differs in in vivo drug efficacy experiments, calling for proper validation of individual stereoisomers in animal studies. Furthermore, by generating a large library of compounds with defined absolute configurations, we lay the groundwork for computational chemists to further optimize and rationally design specific monoamine transporter reuptake inhibitors.
Life on the edge: The effects of building facade three dimensionality on public social behaviour

Links between the built environment and human behaviour have long been of interest to those involved in the fields of urban planning and architecture, but direct assessments of the links between the three-dimensional building facade form and human behaviour are rare. Much work has been completed on subjects’ responses to the aesthetic of architectural frontages but this has generally been conducted using two-dimensional images of structures and in no way assesses human responses when in the presence of these structures. This research has set about observing the behaviour of individuals and groups in the public realm and recording their reactions to architecture which has a distinct three-dimensional character, with particular reference to the street level facade. The behaviour was recorded and quantified and indicated that there is significant differences in human behaviour around these various types of architecture.
Comparative Clinical Study of Suprathel® and Jelonet® Wound Dressings in Burn Wound Healing after Enzymatic Debridement

Following the enzymatic debridement of deep dermal burns, the choice of wound dressing is crucial for providing an adequate environment and suitable conditions for rapid wound healing. As Suprathel® and fatty gauze (Jelonet®) are the most commonly used dressings in burn centers, the aim of this study is to compare Suprathel® and Jelonet® in the treatment of deep dermal burns after enzymatic debridement with respect to wound healing, patient comfort, and pain. A total of 23 patients with deep dermal burns of the hand or foot (mean total body surface area of 4.31%) were included in this prospective, unicentric, open, comparative, and intra-individual clinical study. After enzymatic debridement, wounds were divided into two areas: one was treated with Suprathel® and the other with Jelonet®. Suprathel® remained on the wounds without dressing changes while Jelonet® was regularly changed. Wound healing, infection, bleeding, exudation, time for dressing changes, and pain were documented (from days 2 to 48) after injury. Satisfactory results were obtained in 22 cases; only one patient had to undergo a second debridement followed by skin grafting. No significant difference in time to final wound healing could be observed (18–19 d). Patients reported significantly less pain during the dressing changes for Suprathel® compared to Jelonet®. Furthermore, the wound areas treated with Suprathel® showed significantly less exudation and bleeding. Wound infections rarely occurred in both groups. In conclusion, the authors found that both wound dressings could be used to achieve safe and rapid wound healing after the enzymatic debridement of deep dermal burns of the hands and feet. However, compared to Jelonet®, Suprathel® showed superior results in terms of patient comfort and pain reduction.
Improving Surface Properties of PEEK for Dental Applications by Using Piranha Solution

Background “Polyetheretherketone (PEEK)” is a biocompatible, high-strength polymer that is well-suited for use in dental applications due to its unique properties. However, achieving good adhesion between PEEK and hydrophilic materials such as dental adhesives or cement can be challenging. Also, this hydrophobicity may affect the use of PEEK as an implant material. Surface treatment or conditioning is often necessary to improve surface properties. The piranha solution is the treatment of choice to be explored for this purpose. Methods PEEK disks of 10 mm diameter and 2 mm thickness were used in this study. Those samples were divided into five groups (each group has five samples). The first is the control group, in which no acid treatment was used; the second group undergoes sulfuric acid treatment. The remaining three groups were treated with Piranha solution; each group used a different concentration (1 : 3, 1 : 5, and 1 : 7 hydrogen peroxide to sulfuric acid, respectively). The period of treatment was 60 s for all groups. Wettability and surface roughness tests were done for the five groups. In statistical analysis, Shapiro–Wilk test was used to check the assumption of normality and to determine the statistical significance among groups; a one-way analysis of variance was employed. Subsequently, for multiple comparisons, Tukey's honestly significant difference post hoc test was performed. Results The Piranha solution treatment groups showed a higher wettability compared to the control group and the group treated with sulfuric acid. Additionally, the Piranha solution treatment with a higher concentration of hydrogen peroxide (1 : 3) resulted in greater improvement in surface roughness compared to the control group and the lower concentration groups (1 : 5 and 1 : 7), while the sulfuric acid treated group showed the highest surface roughness. Conclusion The results of this study suggest that the piranha solution can be an effective method for improving the surface characteristics of PEEK to be used in different dental applications, especially as a dental implant material, due to the increase in wettability and surface roughness.
Developing and Planning a Protocol for Implementing Health Promoting Animal Assisted Interventions (AAI) in a Tertiary Health Setting

The Ottawa Charter identifies that multiple levels of government, non-government, community, and other organizations should work together to facilitate health promotion, including in acute settings such as hospitals. We outline a method and protocol to achieve this, namely an Action Research (AR) framework for an Animal Assisted Intervention (AAI) in a tertiary health setting. Dogs Offering Support after Stroke (DOgSS) is an AR study at a major tertiary referral hospital. AAI has been reported to improve mood and quality of life for patients in hospitals. Our project objectives included applying for funding, developing a hospital dog visiting Action Research project, and, subsequent to ethics and governance approvals and finance, undertaking and reporting on the Action Research findings. The Action Research project aimed to investigate whether AAI (dog-visiting) makes a difference to the expressed mood of stroke patients and their informal supports (visiting carers/family/friends), and also the impact these visits have on hospital staff and volunteers, as well as the dog handler and dog involved. We provide our protocol for project management and operations, setting out how the project is conducted from conception to assess human and animal wellbeing and assist subsequent decision-making about introducing dog-visiting to the Stroke Unit. The protocol can be used or adapted by other organizations to try to avoid pitfalls and support health promotion in one of the five important action areas of the Ottawa Charter, namely that of reorienting health services.
U–Pb age constraints on the Carboniferous-Permian transition in continental basins of eastern equatorial Pangaea (France): implications for the depositional history and correlations across the late Variscan Belt

Intramountain late Carboniferous–Permian basins of western Europe developed during the latest orogenic stages of the Variscan Mountain Belt in eastern Pangaea, at equatorial palaeolatitudes. Their stratigraphic framework is mainly based on continental subdivisions (e.g. Stephanian and Autunian continental stages), which can be contentious due to biostratigraphic biases, resulting in long-distance diachronous subdivisions. To provide precise inter-basinal and global correlations to the internationally recognized chronostratigraphic marine stages, this study reports new U–Pb geochronology from the Aumance and Decize–La Machine basins, located in the northern French Massif Central. Zircon grains extracted from three volcanic ash-fall layers give weighted mean 206 Pb/ 238 U ages of 299.11 ± 0.35 Ma; 298.73 ± 0.36 Ma and 298.59 ± 0.35 Ma (2σ total propagated uncertainty) by the chemical abrasion–isotope dilution–thermal ionization mass spectrometry (CA-ID-TIMS) method, coinciding with the Carboniferous–Permian transition (Gzhelian and Asselian stages). These ages imply that the northern Massif Central basins developed synchronously in relatively short periods of time (<10 Myr), reflecting substantial sedimentation rates. Finally, the new chronology of infilling of these basins confirms that they were connected during the late Carboniferous and early Permian periods, improving the knowledge on the late-orogenic Variscan geodynamic setting in this area. Supplementary material: https://doi.org/10.6084/m9.figshare. c.6805228
Neighborhood-Enhanced Supervised Contrastive Learning for Collaborative Filtering

While effective in recommendation tasks, collaborative filtering (CF) techniques face the challenge of data sparsity. Researchers have begun leveraging contrastive learning to introduce additional self-supervised signals to address this. However, this approach often unintentionally distances the target user/item from their collaborative neighbors, limiting its efficacy. In response, we propose a solution that treats the collaborative neighbors of the anchor node as positive samples within the final objective loss function. This paper focuses on developing two unique supervised contrastive loss functions that effectively combine supervision signals with contrastive loss. We analyze our proposed loss functions through the gradient lens, demonstrating that different positive samples simultaneously influence updating the anchor node's embeddings. These samples' impact depends on their similarities to the anchor node and the negative samples. Using the graph-based collaborative filtering model as our backbone and following the same data augmentation methods as the existing contrastive learning model SGL, we effectively enhance the performance of the recommendation model. Our proposed Neighborhood-Enhanced Supervised Contrastive Loss (NESCL) model substitutes the contrastive loss function in SGL with our novel loss function, showing marked performance improvement. On three real-world datasets, Yelp2018, Gowalla, and Amazon-Book, our model surpasses the original SGL by 10.09%, 7.09%, and 35.36% on NDCG@20, respectively.
The Role of Leadership and Motivation on Employee Performance: PT. Multi Media Kabar Case Study

This research aims to determine the influence of leadership and motivation on employee performance at PT. Multi Media Kabar. This type of research is quantitative. The data sources used in this research are direct observation and filling out questionnaires by employee respondents of PT. Multi Media Kabar. This research uses multiple regression analysis. The research results show that leadership and motivation partially have a significant positive effect on employee performance at PT. Multi Media Kabar. The analysis results through calculating the correlation coefficient (R) show a solid positive relationship between leadership and motivation factors and employee performance variables (Y). The results of the analysis through calculating the coefficient of determination (R2) show that leadership and motivation factors have a reasonably significant contribution or contribution to the variation (up and down) of employee performance (Y), in addition to the variation explained by other factors.
The Terrestrial NPP Simulation in China since 6ka BP

A better understanding of the long-term global carbon cycle required estimate of the changes in terrestrial carbon storage after the last glacial period. The results of simulation at mid-Holocene (MH) from PMIP (Paleoclimate Modeling Intercomparison Project) and the modern data from CRU (Climate Research Unit,East Anglia University, UK) allow us to use the Atmosphere-Vegetation Interaction Model (AVIM) to simulate the Chinese terrestrial net primary productivity (NPP) at 6ka BP and present time. The change of NPP and total NPP in China from now to mid-Holocene are about 54 g-m? 2yr-1 and 0.63 Pg yr-1,respectively, mainly due to the build-up of temperate forest and tropical rainforest. Chinese terrestrial NPP variation from MH to now is closely related to the variation in intensity of Asian monsoon, which controlled the climate-vegetation pattern change.