Miracle-dz/UniFAR-FTUs huggingface dataset:
Association between serum Klotho levels and the prevalence of diabetes among adults in the United States

Background Diabetes is a critical contributor to the pathogenesis of cardiovascular diseases. Klotho is an anti−aging protein with cardiovascular-renal protective effects. However, the relationship between serum Klotho levels and diabetes remains poorly understood. Objectives This study aimed to investigate the relationship between serum Klotho levels and diabetes in US adults. Methods We analyzed the cross-sectional data obtained from 13751 subjects aged 40-79 years in the National Health and Nutrition Examination Survey (NHANES) (2007–2016). Serum Klotho concentration was measured using an enzyme-linked immunosorbent assay (ELISA) and categorized into four quartiles (Q1-Q4). Multivariate logistic regression and restricted cubic spline (RCS) regression were conducted to explore the association between serum Klotho levels and the prevalence of diabetes. Results As compared with quartile 1, serum Klotho levels in quartiles 2-4 yielded odds ratios (OR) (95% CI) of diabetes of 0.96 (0.80–1.15), 0.98 (0.82–1.18), and 1.25 (1.04–1.50), respectively, after covariate adjustment (P for trend = 0.018). The results implied an increased risk of diabetes. The RCS plot showed a U-shaped relationship linking serum Klotho levels with diabetes (P for nonlinearity = 0.003). Conclusions In summary, a nonlinear and positive association was found between serum Klotho levels and the prevalence of diabetes. Further study is needed to verify the causality of this association and elucidate the underlying mechanisms.
Analysis of the correlation between non-alcoholic fatty liver disease and the risk of colorectal neoplasms

This study aims at assessing the potential association between non-alcoholic fatty liver disease (NAFLD) and colorectal neoplasms (CRN). PubMed, Cochrane Library, and Embase were searched for cohort studies. 14 cohort studies with a total population of 38,761,773 were included for meta-analysis after selection. The results showed that NAFLD is related to an increased risk of CRN (OR = 1.23; 95% CI: 1.14–1.32; I2 = 70.7%, p < 0.001). In the subgroup analysis, NAFLD were found to be the independent risk factor of colorectal adenoma (CRA) (OR = 1.29; 95% CI = 1.15–1.45; I2 = 66.4%) and colorectal cancer (CRC) (OR = 1.13; 95% CI = 1.12–1.15; I2 = 69.4%). There is no close correlation between smoking status of NAFLD patients and CRN. Interestingly, bioinformatics analysis revealed that there were overlap of dysregulated gene sets among NAFLD, CRC, and two recently identified regulated cell death types, ferroptosis and cuproptosis, respectively. Our meta- and bioinformatics analysis shows that NAFLD increases the risk of CRN. Ferroptosis and cuproptosis may be the critical links between NAFLD and CRN, respectively. These findings here support that NAFLD is necessary to be considered as an emerging risk factor for CRN.
COVID-19 vaccines reduce the risk of SARS-CoV-2 reinfection and hospitalization: Meta-analysis

The addictive protection against SARS-CoV-2 reinfection conferred by vaccination, as compared to natural immunity alone, remains to be quantified. We thus carried out a meta-analysis to summarize the existing evidence on the association between SARS-CoV-2 vaccination and the risk of reinfection and disease. We searched MedLine, Scopus and preprint repositories up to July 31, 2022, to retrieve cohort or case-control studies comparing the risk of SARS-CoV-2 reinfection or severe/critical COVID-19 among vaccinated vs. unvaccinated subjects, recovered from a primary episode. Data were combined using a generic inverse-variance approach. Eighteen studies, enrolling 18,132,192 individuals, were included. As compared to the unvaccinated, vaccinated subjects showed a significantly lower likelihood of reinfection (summary Odds Ratio—OR: 0.47; 95% CI: 0.42–0.54). Notably, the results did not change up to 12 months of follow-up, by number of vaccine doses, in studies that adjusted for potential confounders, adopting different reinfection definitions, and with different predominant strains. Once reinfected, vaccinated subjects were also significantly less likely to develop a severe disease (OR: 0.45; 95% CI: 0.38–0.54). Although further studies on the long-term persistence of protection, under the challenge of the new circulating variants, are clearly needed, the present meta-analysis provides solid evidence of a stronger protection of hybrid vs. natural immunity, which may persist during Omicron waves and up to 12 months.
Phase transitions in AdS soliton spacetime through marginally stable modes

We investigate the marginally stable modes of the scalar (vector) perturbations in the AdS soliton background coupled to electric field. In the probe limit, we find that the marginally stable modes can reveal the onset of the phase transitions of this model. The critical chemical potentials obtained from this approach are in good agreement with the previous numerical or analytical results.
Searching for a Z′ gauge boson in an anomaly-free U(1)′ gauge family model

We study a simple ultraviolet complete and anomaly-free Z' model based on a U(1)' gauge family symmetry without introducing extra fermions beyond the standard model. The U(1)' group is diagonal in the three-family space in which the U(1)' charges of the first and second families are the same but different from those of the third family. After spontaneous symmetry breaking and rotating to the mass eigenstates of quarks and leptons, there exist, in general, both flavor-conserving and flavor-changing couplings. In the flavor-conserving case, we use the latest dijet and dilepton search at the LHC to constrain the mass and gauge couplings of Z'. Also we show that in the flavor-changing and left–right asymmetry case, the t-channel Z' process can only contribute to part of the forward–backward asymmetry in the top quark pair production observed at the Tevatron by taking into account the constraint from the same sign top production at the LHC.
Contouring lumbosacral plexus nerves with MR neurography and MR/CT deformable registration technique

Purpose It is difficult to contour nerve structures with the naked eye due to poor differentiation between the nerve structures with other soft tissues on CT images. Magnetic resonance neurography (MRN) has the advantage in nerve visualization. The purpose of this study is to identify one MRN sequence to better assist the delineation of the lumbosacral plexus (LSP) nerves to assess the radiation dose to the LSP using the magnetic resonance (MR)/CT deformable coregistration technique. Methods A total of 18 cases of patients with prostate cancer and one volunteer with radiation-induced lumbosacral plexopathy (RILSP) were enrolled. The data of simulation CT images and original treatment plans were collected. Two MRN sequences (Lr_NerveVIEW sequence and Cs_NerveVIEW sequence) were optimized from a published MRN sequence (3D NerveVIEW sequence). The nerve visualization ability of the Lr_NerveVIEW sequence and the Cs_NerveVIEW sequence was evaluated via a four-point nerve visualization score (NVS) scale in the first 10 patients enrolled to determine the better MRN sequence for assisting nerve contouring. Deformable registration was applied to the selected MRN sequence and simulation CT images to get fused MR/CT images, on which the LSP was delineated. The contouring of the LSP did not alter treatment planning. The dosimetric data of the LSP nerve were collected from the dose–volume histogram in the original treatment plans. The data of the maximal dose (Dmax) and the location of the maximal radiation point received by the LSP structures were collected. Results The Cs_NerveVIEW sequence gained lower NVS scores than the Lr_NerveVIEW sequence (Z=-2.887, p=0.004). The LSP structures were successfully created in 18 patients and one volunteer with MRN (Lr_NerveVIEW)/CT deformable registration techniques, and the LSP structures conformed with the anatomic distribution. In the patient cohort, the percentage of the LSP receiving doses exceeding 50, 55, and 60 Gy was 68% (12/18), 33% (6/18), and 17% (3/18), respectively. For the volunteer with RILSP, the maximum irradiation dose to his LSP nerves was 69 Gy. Conclusion The Lr_NerveVIEW MRN sequence performed better than the Cs_NerveVIEW sequence in nerve visualization. The dose in the LSP needs to be measured to understand the potential impact on treatment-induced neuropathy.
Dynamic universality class of large-N gauge theories

In dynamic critical phenomena, singular behaviors appear not only in the order parameter but also in the other transport coefficients (due to the mode-mode coupling). However, this effect has not been observed in the AdS/CFT duality. We point out that this mode-mode coupling is suppressed by 1/N{sup 2} in the large-N gauge theories which correspond to model H in the classification of Hohenberg and Halperin. Thus, the effect cannot be seen in the classical supergravity approximation. We illustrate this point using the example of the N=4 super-Yang-Mills theory at a finite chemical potential. We also discuss the implications of this result to heavy-ion collisions.
HELIOSEISMIC DETECTION OF DEEP MERIDIONAL FLOW

Steady meridional flow does not make any first-order perturbations to the frequencies of helioseismic normal modes. It does, however, Doppler shift the local wavenumber, thereby distorting the eigenfunctions. For high-degree modes, whose peaks in a power spectrum are blended into continuous ridges, the effect of the distortion is to shift the locations of those ridges. From this blended superposition of modes, one can isolate oppositely directed wave components with the same local horizontal wavenumber and measure a frequency difference which can be safely used to infer the subsurface background flow. But such a procedure fails for the components of the more deeply penetrating low-degree modes that are not blended into ridges. Instead, one must analyze the spatial distortions explicitly. With a simple toy model, we illustrate a method by which that might be accomplished by measuring the spatial variation of the oscillation phase. We estimate that by using this procedure, it might be possible to infer meridional flow deep in the solar convection zone.
Calculation of thermal noise in grating reflectors

Grating reflectors have been repeatedly discussed to improve the noise performance of metrological applications due to the reduction or absence of any coating material. So far, however, no quantitative estimate on the thermal noise of these reflective structures exists. In this work we present a theoretical calculation of a grating reflector’s noise. We further apply it to a proposed third generation gravitational wave detector. Depending on the grating geometry, the grating material, and the temperature, we obtain a thermal noise decrease by up to a factor of 10 compared to conventional dielectric mirrors. Thus the use of grating reflectors can substantially improve the noise performance in metrological applications.
The influence of positive affect on sensitivity to important omissions

It is surprisingly difficult to notice when important information is missing (omission neglect) and yet, social media, advertisements, and other forms of communication typically only include one-sided information or positive attributes and omit opposing views or negative attributes. Even though it is surprisingly difficult to overcome this natural tendency, there are circumstances when decision makers are more sensitive to omissions. Understanding how and when decision makers can overcome this omission neglect tendency can be helpful to improve decision making in many situations. This paper investigates positive affect as a potential factor that can elicit sensitivity to omissions and alert decision makers to the need for additional information when important information is, in fact, missing. Four experiments use a consumer product choice situation to show that when decision makers are making an important decision, positive affect increases the likelihood that they will report a greater desire for additional product information (experiments 3 and 4) and temper their purchase interest in the target product. These results are shown using inference (experiments 1, 2, and 3) and by explicitly comparing a product choice with full and partial information (experiment 4). The results are discussed in terms of omission neglect literature as well as implications of the results for understanding the role of positive affect in information processing, judgment, and decision-making. These findings have implications for policy makers, marketers and others who are interested in message processing.
Genetic variations and microbiome of the poultry red mite Dermanyssus gallinae

The poultry red mite Dermanyssus gallinae poses a significant threat to the health of hens and poultry production. A comprehensive understanding of D. gallinae is necessary to develop sustainable and efficacious control methods. Here we examined 144 D. gallinae collected from 18 poultry farms throughout the Japanese Archipelago for their genetic variations based on mitochondrial cytochrome c oxidase subunit I (COI) sequences, and microbiome variations based on amplicon sequencing of the 16S ribosomal RNA gene. According to COI sequencing, the Japanese samples were categorized into three haplogroups, which did not reflect the geographical distribution. Microbiome analyses found that the major bacteria associated with D. gallinae were Bartonella, Cardinium, Wolbachia, and Tsukamurella, with Bartonella being most predominant. Among 144 individual mites, all possessed one of the two major types of Bartonella (Bartonella sp. A), while 140 mites possessed the other type (Bartonella sp. B). The presence of the two strains of Bartonella was also confirmed by a single copy gene, rpoB. The presence of Bartonella in laid eggs suggested transovarial vertical transmission. Given that obligate blood-feeding arthropods generally require a supply of B vitamins from symbiotic bacteria, Bartonella may play an important role in mite survival. Rickettsiella, a major symbiont in European D. gallinae populations, and suggested to be an important symbiont by genomic data, was rarely found in Japanese populations. Cardinium detected from D. gallinae fell into a major clade found widely in arthropods, whereas Wolbachia detected in Japanese D. gallinae appear to be a new lineage, located at the base of Wolbachia phylogeny. Of the mitochondrial phylogeny, infection patterns of Cardinium and Wolbachia were strongly correlated, possibly suggesting one or both of the symbionts induce reproductive manipulations and increase spread in the host populations.
Deep secrets of intermediate-mass giants and supergiants

Context. Recent observational results have demonstrated an increase in the surface Na abundance that correlates with stellar mass for red giants between 2 and 3 M⊙. This trend supports evolutionary mixing processes as the explanation for Na overabundances seen in some red giants. In this same mass range, the surface Al abundance was shown to be constant. Aims. Our main aim was to extend the investigation of the Na and Al surface abundances to giants more massive than 3 M⊙. We sought to establish accurately whether the Na abundances keep increasing with stellar mass or a plateau is reached. In addition, we investigated whether mixing can affect the surface abundance of Al in giants more massive than 3 M⊙. Methods. We obtained new high-resolution spectra of 20 giants in the field of 10 open clusters; 17 of these stars were found to be members of 9 clusters. The giants have masses between 2.5 M⊙ and 5.6 M⊙. A model atmosphere analysis was performed and abundances of up to 22 elements were derived using equivalent widths. Additionally, abundances of C, N, and O were determined using spectrum synthesis. The abundances of Na and Al were corrected for non-local thermodynamic equilibrium (non-LTE) effects. Moreover, to extend the mass range of our sample, we collected from the literature high-quality C, N, O, and Na abundances of 32 Galactic Cepheids with accurate masses in the range between 3 M⊙ and 14 M⊙. Results. The surface abundances of C, N, O, Na, and Al were compared to predictions of stellar evolution models with and without the inclusion of rotation-induced mixing. The surface abundances of most giants and Cepheids of the sample can be explained by models without rotation. For giants above Ȉ2.5 M⊙, the Na abundances reach a plateau level of about [Na/Fe] ~ 0.20–0.25 dex (in non-LTE). This is true for both Cepheids and giants in open clusters. Regarding Al, the non-LTE [Al/Fe] ratios are mostly close to solar and suggest that Al is not affected by the first dredge-up up to ~5.0 M⊙. Our results support previous works that found models with rotation to overestimate the mixing effects in intermediate-mass stars.
Congenital absence of the vas deferens with hypospadias or without hypospadias: Phenotypic findings and genetic considerations

Congenital absence of the vas deferens (CAVD) is a major cause of obstructive azoospermia. Mutations of CFTR and ADGRG2 cause the majority of CAVD. Despite this, 10%–20% of CAVD patients remain without a clear genetic diagnosis. Herein, the CFTR and ADGRG2 genes were first sequenced using Sanger sequencing in 50 CAVD patients. Whole-exome sequencing (WES) was used to further identify potential novel genetic causes in CAVD with hypospadias. In total, 29 of 50 CAVD patients carried at least one CFTR mutation, but no ADGRG2 mutation was found. 5T was found to be the most frequent variant in our CAVD populations. Seven CAVD patients with hypospadias were further analyzed using WES. No homozygous or compound heterozygous mutations related to disorders of sex development (DSDs) or male infertility were identified by WES. CAVD with hypospadias presented lower testicular volume (9.71 ± 2.14 ml vs. 14.45 ± 2.93 ml, p < 0.001) and higher FSH level (FSH: 7.28 ± 3.91 IU/L vs. 4.24 ± 1.96 IU/L, p = 0.027) than CAVD without hypospadias. It is worth noting that neither CFTR or ADGRG2 mutation nor homozygous or compound heterozygous gene mutations were identified in seven CAVD cases with hypospadias. However, nine heterozygous or hemizygous mutations were selected as potential pathogenic genes in CAVD with hypospadias. In conclusion, CFTR variants, especially 5T, play a major role in the Chinese CAVD population. CAVD with hypospadias shows relatively lower testicular spermatogenesis, suggesting a different genetic basis or pathogenic factor from cystic fibrosis/CAVD or unilateral renal agenesis/CAVD.
Multimodal Functions as Flow Signatures in Complex Porous Media.

This study refutes the premise that the distribution of flow speeds in complex porous media can be described by a simple function such as a normal or exponential variation. In many complex porous media, including those relevant for subsurface storage and recovery applications, a separation of scales exists between larger inter-granular pores and micro-porosity inside the grains, leading to different flow signatures that need to be described by multimodal functions with distinct flow field characteristics. We demonstrate this finding by devising a novel methodology to simulate fluid flow in carbonate rock based on a representation of the pore space obtained by differential X-ray imaging. The permeability assignment in the micro-porous space is estimated from the pore size inferred from mercury injection porosimetry. Model predictions considering micro-porosity agree well with experimentally measured porosities and permeabilities. The micro-porosity can contribute significantly to the overall permeability, particularly in the more heterogeneous media.
Improved Speech Separation with Time-and-Frequency Cross-domain Joint Embedding and Clustering

Speech separation has been very successful with deep learning techniques. Substantial effort has been reported based on approaches over spectrogram, which is well known as the standard time-and-frequency cross-domain representation for speech signals. It is highly correlated to the phonetic structure of speech, or "how the speech sounds" when perceived by human, but primarily frequency domain features carrying temporal behaviour. Very impressive work achieving speech separation over time domain was reported recently, probably because waveforms in time domain may describe the different realizations of speech in a more precise way than spectrogram. In this paper, we propose a framework properly integrating the above two directions, hoping to achieve both purposes. We construct a time-and-frequency feature map by concatenating the 1-dim convolution encoded feature map (for time domain) and the spectrogram (for frequency domain), which was then processed by an embedding network and clustering approaches very similar to those used in time and frequency domain prior works. In this way, the information in the time and frequency domains, as well as the interactions between them, can be jointly considered during embedding and clustering. Very encouraging results (state-of-the-art to our knowledge) were obtained with WSJ0-2mix dataset in preliminary experiments.
HAT-P-20b–HAT-P-23b: FOUR MASSIVE TRANSITING EXTRASOLAR PLANETS

We report the discovery of four relatively massive (2–7 MJ) transiting extrasolar planets. HAT-P-20b orbits the moderately bright V = 11.339 K3 dwarf star GSC 1910-00239 on a circular orbit, with a period P = 2.875317 ± 0.000004 days, transit epoch Tc = 2455080.92661 ± 0.00021 (BJDUTC), and transit duration 0.0770 ± 0.0008 days. The host star has a mass of 0.76 ± 0.03 M☉, radius of 0.69 ± 0.02 R☉, effective temperature 4595 ± 80 K, and metallicity [Fe/H] = +0.35 ± 0.08. The planetary companion has a mass of 7.246 ± 0.187 MJ and a radius of 0.867 ± 0.033 RJ yielding a mean density of 13.78 ± 1.50 g cm−3. HAT-P-21b orbits the V = 11.685 G3 dwarf star GSC 3013-01229 on an eccentric (e = 0.228 ± 0.016) orbit, with a period P = 4.124481 ± 0.000007 days, transit epoch Tc = 2454996.41312 ± 0.00069, and transit duration 0.1530 ± 0.0027 days. The host star has a mass of 0.95 ± 0.04 M☉, radius of 1.10 ± 0.08 R☉, effective temperature 5588 ± 80 K, and metallicity [Fe/H] = +0.01 ± 0.08. The planetary companion has a mass of 4.063 ± 0.161 MJ and a radius of 1.024 ± 0.092 RJ yielding a mean density of 4.68+1.59− 0.99 g cm−3. HAT-P-21b is a borderline object between the pM and pL class planets, and the transits occur near apastron. HAT-P-22b orbits the bright V = 9.732 G5 dwarf star HD 233731 on a circular orbit, with a period P = 3.212220 ± 0.000009 days, transit epoch Tc = 2454930.22001 ± 0.00025, and transit duration 0.1196 ± 0.0014 days. The host star has a mass of 0.92 ± 0.03 M☉, radius of 1.04 ± 0.04 R☉, effective temperature 5302 ± 80 K, and metallicity [Fe/H] = +0.24 ± 0.08. The planet has a mass of 2.147 ± 0.061 MJ and a compact radius of 1.080 ± 0.058 RJ yielding a mean density of 2.11+0.40− 0.29 g cm−3. The host star also harbors an M-dwarf companion at a wide separation. Finally, HAT-P-23b orbits the V = 12.432 G0 dwarf star GSC 1632-01396 on a close to circular orbit, with a period P = 1.212884 ± 0.000002 days, transit epoch Tc = 2454852.26464 ± 0.00018, and transit duration 0.0908 ± 0.0007 days. The host star has a mass of 1.13 ± 0.04 M☉, radius of 1.20 ± 0.07 R☉, effective temperature 5905 ± 80 K, and metallicity [Fe/H] = +0.15 ± 0.04. The planetary companion has a mass of 2.090 ± 0.111 MJ and a radius of 1.368 ± 0.090 RJ yielding a mean density of 1.01 ± 0.18 g cm−3. HAT-P-23b is an inflated and massive hot Jupiter on a very short period orbit, and has one of the shortest characteristic infall times (7.5+2.9− 1.8 Myr) before it gets engulfed by the star.
Linear collisionless Landau damping in Hilbert space

The equivalence between the Laplace transform (Landau, J. Phys. USSR 10 (1946), 25) and Hermite transform (Zocco and Schekochihin, Phys. Plasmas 18, 102309 (2011)) solutions of the linear collisionless Landau damping problem is proven.