Miracle-dz/UniFAR-FTUs huggingface dataset:
Research on Continuous Auditing Based on Multi-agent and Web Services

Continuous auditing technology is an important evolving branch of computer-assisted auditing technology. It gains high attention both from literature and industry because of the outstanding improvements it brings regarding the audit timeliness. This research reviews the three major types of continuous auditing architecture: EAM, ADM and ABM. This paper proposes a continuous auditing architecture based on multi-agent and web services (CAMAWS). The CAMAWS makes the execution of complex audit procedures easy, which is hard to execute in traditionally continuous auditing architecture. The costs of executing audit procedure also minimize, with specially designed functional modules to help manage the audit evidence, knowledge and detected abnormal behaviors. The CAMAWS shows a promising future of using multi-agent in continuous auditing to simulate the collaborative work of manual audit team.
Central and Eastern European trade unions after the EU enlargement

This article presents recent responses on the part of Central and Eastern European (CEE) trade unions to economic and social challenges in the post-enlargement period. Shifting the focus away from structural union weakness, the article looks at trade union potential for action, organizational capacity, resource building and policy influence. Despite their structural weaknesses, CEE unions demonstrate capacities that might enable them actively to shape working conditions and their internal resources are not completely depleted. However, the character of these resources and the kinds of union action have been changing. Traditional resources based on membership and involvement in collective bargaining have lost prominence in favour of unions’ increased focus on mobilization, public protests and political support.
Responding to negative health events: A test of the Bad News Response Model

People can respond to bad news in a variety of ways. The Bad News Response Model suggests that three aspects of bad news (the controllability, likelihood, and severity of negative consequences) predict which response (Watchful Waiting, Active Change, or Acceptance) people are likely to choose. This article presents an initial test of the predictions of the Bad News Response Model. College students (N = 234) and older adults (N = 116) read a scenario about a person with a suspicious mole that varied in the controllability, likelihood, and severity of the outcomes. Consistent with our predictions, people prefer Watchful Waiting when controllability, likelihood, and severity are low, Active Change when controllability and likelihood are high, and Acceptance when controllability is low. These findings provide support for the Bad News Response Model and suggest that responses to bad news may be foreseeable based on the type of news people receive.
Farm size, risk aversion, and the adoption of new technology under uncertainty.

A model dealing with the role of risk aversion and credit constraints in the production decisions of farmers who grow both modern and traditional crops is described. The model can address such questions as: the effect of attitudes toward risk on factor use and output mix; differences between farms of different sizes; the implications of credit constraints on factor use and output mix; and effects on income distribution. Equations are provided that consider the optimal input of fertilizer, the optimal allocation of land, and the consequences of credit limitations. In the specific case of the modern crop versus traditional crop decision model, the analysis clarifies the effects of risk, risk aversion, farm size, and credit constraints on input use, output scale, and crop mix decisions. Results are shown to depend on various behavioral or technical rules that have already been established in empirical studies or on such generally accepted notions as the properties of utility functions. Overall, the analysis helps to explain conflicting evidence on patterns of production by farms of different sizes and, in some cases, refutes or qualifies common beliefs. Statistical data are provided. 20 references.
The Effects of Pension Funds on Markets Performance: A Review

The worldwide reforming process of pension systems triggered by the demographic transition and globalization has led several countries to implement multi‐pillar pension systems and enhance pension funds. For this reason the studies on the effects that pension funds exert on markets performance have been flourishing in the last decades. In this paper, we provide an updated review of the empirical advances in this field of study, with particular focus on the effects that pension funds produce on labour markets, financial markets and economic growth.
Management of acute myelogenous leukemia in the elderly.

BACKGROUND Acute myelogenous leukemia (AML) is a hematopoietic neoplasm that primarily affects older adults. Despite scientific advances into the epidemiologic, genetic, and biological features of AML, this disease remains fatal to the majority of patients, particularly older individuals. METHODS We review the biologic and clinical characteristics of AML in the elderly and the treatment options that have emerged for them during the past several years. RESULTS Several biologic features of AML differ between older and younger individuals. Older patients often have disease that expresses multidrug resistance phenotype and cytogenetic abnormalities, which may be responsible in large part for the poor outcomes observed in older-aged subgroups. Traditional cytotoxic chemotherapy is associated with a low complete response rate and a high treatment-related mortality in older patients, which explains in part the poorer outcomes in cohorts over 60 years of age. Research into the pathophysiology of AML has revealed an abundance of intracellular signaling events that govern proliferation and survival of the malignant cell. Such discoveries have promoted recognition of new molecular and antigenic targets (eg, Flt-3 kinase, Ras, CD33 antigen) to which therapeutic development may be aimed. CONCLUSIONS New therapies directed against these unique targets may add to the current arsenal of antileukemic regimens and improve response rates and survival in older patients.
Ecto-nucleoside Triphosphate Diphosphohydrolase 1 (E-NTPDase1/CD39) Regulates Neutrophil Chemotaxis by Hydrolyzing Released ATP to Adenosine*

Polymorphonuclear neutrophils release ATP in response to stimulation by chemoattractants, such as the peptide N-formyl-methionyl-leucyl-phenylalanine. Released ATP and the hydrolytic product adenosine regulate chemotaxis of neutrophils by sequentially activating purinergic nucleotide and adenosine receptors, respectively. Here we show that that ecto-nucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1, CD39) is a critical enzyme for hydrolysis of released ATP by neutrophils and for cell migration in response to multiple agonists (N-formyl-methionyl-leucyl-phenylalanine, interleukin-8, and C5a). Upon stimulation of human neutrophils or differentiated HL-60 cells in a chemotactic gradient, E-NTPDase1 tightly associates with the leading edge of polarized cells during chemotaxis. Inhibition of E-NTPDase1 reduces the migration speed of neutrophils but not their ability to detect the orientation of the gradient field. Studies of neutrophils from E-NTPDase1 knock-out mice reveal similar impairments of chemotaxis in vitro and in vivo. Thus, E-NTPDase1 plays an important role in regulating neutrophil chemotaxis by facilitating the hydrolysis of extracellular ATP.
HEI engagement with SMEs: developing social capital

Purpose – The need to develop a greater understanding about the creation of social capital and how this might impact on entrepreneurship and the development of the small‐ to medium‐sized enterprise (SME) sector requires further research. This paper aims to consider to what extent engagement with higher education institutions (HEIs) by SMEs creates social capital and network benefits.Design/methodology/approach – This paper follows the experiences of five SME owners who participated in the Lancaster University LEAD programme (a leadership programme for owner/managers who want to develop their leadership capabilities and grow their business) between 2004 and 2006. Qualitative techniques are used to consider networking activities, use and development of social capital and experiences. A framework for data collection and analysis was developed from the literature review.Findings – Results show that the experience of engaging with the HEI sector was beneficial. Networks provided the opportunity to create socia.
Software Performance Analytics in the Cloud

The emergence of large-scale software deployments in the cloud has led to several challenges: (1) measuring software performance in the data center, and (2) optimizing software for resource management. This tutorial addresses the two challenges by bringing the knowledge of software performance monitoring in the data center to the world of applying performance analytics. It introduces data transformations for software performance metrics. The transformations enable effective applications of analytics. This tutorial starts with software performance in the small and ends with applying analytics to software performance in the large. In software performance in the small, it summarizes performance tools, data collection and manual analysis. Then it describes monitoring tools that are helpful in performance analysis in the large. The tutorial will guide the audience in applying analytics to performance data obtained by common tools. This tutorial describes how to select analytical methods and what precautions should be taken to get effective results.
Hyperemesis Gravidarum: A Review

Epidemiology of Hyperemesis The condition was described as early as 2000 BC. In an Epidemiological study 70% of all pregnancy were associated with nausea, in 91% of the case the onset was during first three months. This has a tendency to recur. It has been found that there was no difference of intensity, peak nausea or time of onset in successive pregnancy, however the duration decrease. There is a strong correlation between nausea and tolerance of oral contraceptives.
The new product process: an empirically‐based classification scheme

New product successd is largely determined by the way a firm conceives, develops and commercializes a new product—the new product process. Traditionally, the new product process is portrayed as proceeding in an orderly, stepwise fashion from product idea to launch. This article reports the results of a research study whose purpose was to uncover what actually occurs during the new product process. Fifty-eight case histories were obtained from industrial product firms, and their process flow charts analyzed using a novel comparison method. No two projects were found to follow the identical process, and seven distinct types of processes were identified. Several of the processes were found to yield generally inferior results. The “best’ process, in terms of success versus failure and overall program performance, featured a balance between marketing oriented and technically oriented activities, and was characterized by a large number of varied steps in the process.
MYH9‐Related Disease: A Novel Prognostic Model to Predict the Clinical Evolution of the Disease Based on Genotype–Phenotype Correlations

MYH9‐related disease (MYH9‐RD) is a rare autosomal‐dominant disorder caused by mutations in the gene for nonmuscle myosin heavy chain IIA (NMMHC‐IIA). MYH9‐RD is characterized by a considerable variability in clinical evolution: patients present at birth with only thrombocytopenia, but some of them subsequently develop sensorineural deafness, cataract, and/or nephropathy often leading to end‐stage renal disease (ESRD). We searched for genotype–phenotype correlations in the largest series of consecutive MYH9‐RD patients collected so far (255 cases from 121 families). Association of genotypes with noncongenital features was assessed by a generalized linear regression model. The analysis defined disease evolution associated to seven different MYH9 genotypes that are responsible for 85% of MYH9‐RD cases. Mutations hitting residue R702 demonstrated a complete penetrance for early‐onset ESRD and deafness. The p.D1424H substitution associated with high risk of developing all the noncongenital manifestations of disease. Mutations hitting a distinct hydrophobic seam in the NMMHC‐IIA head domain or substitutions at R1165 associated with high risk of deafness but low risk of nephropathy or cataract. Patients with p.E1841K, p.D1424N, and C‐terminal deletions had low risk of noncongenital defects. These findings are essential to patients' clinical management and genetic counseling and are discussed in view of molecular pathogenesis of MYH9‐RD.
Postretrenchment Politics: Policy Feedback in Chile's Health and Pension Reforms

Abstract Through a comparison of three periods of health and pension reform in Chile, this article develops an explanation for the incremental form of social policy change that some Latin American nations have witnessed in recent years, despite the dramatic rise of left governments. It describes “postretrenchment politics,” which constitutes a realignment in the way politics plays out in countries that have undergone social policy retrenchment. In postretrenchment politics, the strengthened position of private business interests, combined with political learning legacies and lock-in effects generated by reforms, results in incremental political change, despite renewed efforts by left parties to address inequality. Global capital also plays an important contextual role, and may influence postretrenchment politics. In postretrenchment politics, newly reformed systems may achieve greater equity, but they do so in fragmented form.
Schizosaccharomyces pombe Ddb1 Is functionally Linked to the Replication Checkpoint Pathway*

Schizosaccharomyces pombe Ddb1 is homologous to the mammalian DDB1 protein, which has been implicated in damaged-DNA recognition and global genomic repair. However, a recent study suggested that the S. pombe Ddb1 is involved in cell division and chromosomal segregation. Here, we provide evidence that the S. pombe Ddb1 is functionally linked to the replication checkpoint control gene cds1. We show that the S. pombe strain lacking ddb1 has slow growth due to delayed replication progression. Flow cytometric analysis shows an extensive heterogeneity in DNA content. Furthermore, the Δddb1 strain is hypersensitive to UV irradiation in S phase and is unable to tolerate a prolonged replication block imposed by hydroxyurea. Interestingly, the Δddb1 strain exhibits a high level of the Cds1 kinase activity during passage through S phase. Moreover, mutation of the cds1 gene relieves the defects observed in Δddb1 strain. The results suggest that many of the defects observed in Δddb1 cells are linked to an aberrant activation of Cds1, and that Ddb1 is functionally linked to Cds1.
Darwinism in disguise? A comparison between Bohr's view on quantum mechanics and QBism

The Copenhagen interpretation is first and foremost associated with Niels Bohr's philosophy of quantum mechanics. In this paper, I attempt to lay out what I see as Bohr's pragmatic approach to science in general and to quantum physics in particular. A part of this approach is his claim that the classical concepts are indispensable for our understanding of all physical phenomena, and it seems as if the claim is grounded in his reflection upon how the evolution of language is adapted to experience. Another, recent interpretation, QBism, has also found support in Darwin's theory. It may therefore not be surprising that sometimes QBism is said to be of the same breed as the Copenhagen interpretation. By comparing the two interpretations, I conclude, nevertheless, that there are important differences.
Discovery of Novel Inhibitors of HIV‐1 Reverse Transcriptase Through Virtual Screening of Experimental and Theoretical Ensembles

Non‐nucleoside reverse transcriptase inhibitors (NNRTIs) are potent anti‐HIV chemotherapeutics. Although there are FDA‐approved NNRTIs, challenges such as the development of resistance have limited their utility. Here, we describe the identification of novel NNRTIs through a combination of computational and experimental approaches. Based on the known plasticity of the NNRTI binding pocket (NNIBP), we adopted an ensemble‐based virtual screening strategy: coupling receptor conformations from 10 X‐ray crystal structures with 120 snapshots from a total of 480 ns of molecular dynamics (MD) trajectories. A screening library of 2864 National Cancer Institute (NCI) compounds was built and docked against the ensembles in a hierarchical fashion. Sixteen diverse compounds were tested for their ability to block HIV infection in human tissue cultures using a luciferase‐based reporter assay. Three promising compounds were further characterized, using a HIV‐1 RT‐based polymerase assay, to determine the specific mechanism of inhibition. We found that 2 of the three compounds inhibited the polymerase activity of RT (with potency similar to the positive control, the FDA‐approved drug nevirapine). Through a computational approach, we were able to discover two compounds which inhibit HIV replication and block the activity of RT, thus offering the potential for optimization into mature inhibitors.
Ontogeny of γ‐aminobutyric acid–immunoreactive neurons in the rhombencephalon and spinal cord of the sea lamprey

The development of neurons expressing γ‐aminobutyric acid (GABA) in the rhombencephalon and spinal cord of the sea lamprey (Petromyzon marinus) was studied for the first time with an anti‐GABA antibody. The earliest GABA‐immunoreactive (GABAir) neurons appear in late embryos in the basal plate of the isthmus, caudal rhombencephalon, and rostral spinal cord. In prolarvae, the GABAir neurons of the rhombencephalon appear to be distributed in spatially restricted cellular domains that, at the end of the prolarval period, form four longitudinal GABAir bands (alar dorsal, alar ventral, dorsal basal, and ventral basal). In the spinal cord, we observed only three GABAir longitudinal bands (dorsal, intermediate, and ventral). The larval pattern of GABAir neuronal populations was established by the 30‐mm stage, and the same populations were observed in premetamorphic and adult lampreys. The ontogeny of GABAergic populations in the lamprey rhombencephalon and spinal cord is, in general, similar to that previously described in mouse and Xenopus. J. Comp. Neurol. 464:17–35, 2003. © 2003 Wiley‐Liss, Inc.
Reverse Phase Compatible TLC-Bioautography for Detection of Tyrosinase Inhibitors.

INTRODUCTION Reverse phase chromatography and bioautographic assays are key tools for natural product bioguided isolation; however, their direct coupling has not been fully achieved. OBJECTIVES To develop a bioautographic assay to detect tyrosinase inhibitors present in complex matrices sorbed on reverse phase (RP) TLC-plates that can be used for bioguided isolation of bioactive compounds. METHODS Enzyme gel entrapment with an amphiphilic copolymer was used for assay development. The gel turns into a brown "skin like" colour due to tyrosinase catalysed oxidation of l-tyrosine. The inhibitors are visualised as clear spots against a brown coloured background. RESULTS The assay was able to localise cinnamaldehyde in Cinnamomum cassia essential oil, as its main constituent with known tyrosinase inhibition properties. The assay allowed the detection of 0.03% (w/w) of kojic acid co-spotted with a methanolic extract of Sphaeralcea bonariensis and chromatographed on RP-TLC. CONCLUSION The developed assay is able to detect, with high sensitivity, tyrosinase inhibitors present in complex matrices that were chromatographed in RP-TLC. Results can be easily read by colour change, inhibitors appear as clear spots in a darker background. Copyright © 2016 John Wiley & Sons, Ltd.
Neuroform in-stent stenosis: incidence, natural history, and treatment strategies.

OBJECTIVE Delayed in-stent stenosis is an important and well-characterized complication of angioplasty and stenting for the treatment of intra- and extracranial atheromatous disease. The current series describes the incidence and natural history of in-stent stenosis after the deployment of the Neuroform stent within the cerebrovasculature for the treatment of aneurysms. METHODS The collaborative Cleveland Clinic Foundation-Barrow Neurological Institute endovascular database was reviewed to identify cases of delayed moderate or severe in-stent stenosis observed during the follow-up of cerebral aneurysms treated with the Neuroform stent. The hospital charts, clinic records, and operative reports for these patients were reviewed. RESULTS Of a total of 156 patients with follow-up, nine (5.8%) cases of moderate or severe delayed (>2 mo) in-stent stenosis were identified, including two parent vessel occlusions. In two cases, patients presented 3 months after stent-supported aneurysm embolization with focal neurological symptoms. Both of these patients were treated with angioplasty. One eventually required surgical bypass. Of the seven asymptomatic patients, four demonstrated some degree of spontaneous resolution at follow-up, one progressed to complete occlusion, one is awaiting further follow-up, and one patient died of unrelated causes. Of the nine patients in the series, five were treated with "bioactive" coils (Matrix, Hydrocoil, Cerecyte), three were treated with bare platinum coils, and one was treated with stenting alone. The earliest time interval to diagnosis was 2.5 months and 3 months for asymptomatic and symptomatic patients, respectively. The earliest interval documented for spontaneous resolution was 9 months. CONCLUSION Delayed Neuroform in-stent stenosis, occurring in 5.8% of cases, is not a rare phenomenon. The stenosis can be symptomatic and may require endovascular treatment or surgical bypass. In asymptomatic patients, a strategy of "watchful waiting" may be effective because many patients demonstrate partial or complete resolution at follow-up. The spontaneous resolution of delayed in-stent stenosis has not been previously described. This may be a phenomenon unique to the application of low radial force, self-expanding stents within the nonatheromatous cerebrovasculature.
Estrogen-Related Fecundity Reduction of Lymnaea ollula Following Fasciola gigantica Infection

Abstract Infection by trematode parasites generally affects life history traits of their intermediate hosts. Reduction in life expectancy and reproductive capacity have previously been documented in Fasciola gigantica-infected Lymnaea ollula, but the influence of the endocrine system on this specific host–parasite interaction has not been previously examined. In the present study, we observed survival, growth pattern, and reproductive output of L. ollula following exposure to F. gigantica. Both the survival and the growth pattern of infected snails were similar to those of the non-infected control group. However, a significant difference was apparent in fecundity, as infected snails consistently showed lower levels of egg and embryo production throughout a 7-wk observation period. Semi-quantitative RT-PCR also revealed down-regulation of estrogen receptor expression in infected snails during the first 4 wk of infection. Nonetheless, the inhibition of estrogen signaling was transient, as they regained expression in the later phase of infection. It is, therefore, suggested that other hormones of the complex endocrine system may be involved in the reduced fecundity of L. ollula following F. gigantica infection.