Miracle-dz/UniFAR-FTUs huggingface dataset:
Production of the RANTES chemokine in delayed-type hypersensitivity reactions: involvement of macrophages and endothelial cells [published erratum appears in J Exp Med 1994 Aug 1;180(2):775]

To understand the selective accumulation of memory T helper lymphocytes and of macrophages in delayed-type hypersensitivity (DTH) granulomas, we studied the in situ production of RANTES, a chemokine initially characterized on the basis of its in vitro chemotactic properties for each of these cell populations. RANTES gene expression was studied by in situ hybridization in 15 human lymph nodes presenting typical DTH lesions related to either sarcoidosis or tuberculosis. A positive signal was detected in all cases. Labeling was specific for the DTH lesions, as very few if any positive cells were detected in the normal residual lymphoid tissue surrounding them or in reactive lymph nodes involved in a B lymphocyte response. RANTES gene expression was associated with the production of the protein, which was detected by immunochemistry in DTH lymph nodes. The morphological characteristics and distribution of positive cells in in situ hybridization and immunochemical experiments indicated that macrophages and endothelial cells, two cell populations not previously reported to produce RANTES, contributed to its production in DTH reactions. The ability of macrophages and endothelial cells to produce RANTES was confirmed by in vitro studies with alveolar macrophages and umbilical vein endothelial cells. In view of the chemotactic properties of RANTES for a limited range of cell populations, these results suggest that RANTES production in DTH granulomas may play a role in the selective accumulation of macrophages and memory T helper lymphocytes characterizing this type of cell-mediated immune reaction, and that macrophages and endothelial cells are involved in this production.
Antioxidant and Cytotoxic Activities of Centella asiatica (L) Urb.

In the present study, the phenolic (Folin-Dennis) and flavonoid (colorimetric assay) constituents, antioxidant [2,2-diphenyl-2-picrylhydrazyl hydrate (DPPH) assay] and cytotoxic activities of an aqueous extract (AE) of Centella asiatica leaves were investigated. The aqueous extract (50 g/L) was obtained by infusion followed by cold maceration for 24 h. The levels of phenolic and flavonoid compounds were 2.86 g/100 g and 0.361 g/100 g, respectively. The AE showed elevated DPPH scavenging activity, with an IC50 value of 31.25 μg/mL. The AE had a promising activity against mouse melanoma (B16F1), human breast cancer (MDA MB-231) and rat glioma (C6) cell lines, with IC50 values of 698.0, 648.0 and 1000.0 μg/mL, respectively. A positive correlation was established between the level of flavonoids, antioxidant and antitumor activities.
Search for gravitational waves from binary black hole inspirals in LIGO data

We report on a search for gravitational waves from binary black hole inspirals in the data from the second science run of the LIGO interferometers. The search focused on binary systems with component masses between 3 and 20 solar masses. Optimally oriented binaries with distances up to 1 Mpc could be detected with efficiency of at least 90%. We found no events that could be identified as gravitational waves in the 385.6 hours of data that we searched.
Leaving an Unknown Maze Using an Error-Prone Compass

Imagine you are trapped in a maze of caves. All you have is an old rusty compass and barely enough light to read it. How much inaccuracy can you allow to ensure that you can leave the maze? Or you are walking in a maze of hedgerows that are on the whole orthogonal. Can you find the exit by counting left and right turns? We consider the problem of escaping from an unknown polygonal maze under limited resources and errors in inputs and motion. It is well known that the Pledge algorithm always finds a path out of an unknown maze without any means of orientation—provided that such a path exists—but it relies on fact that inputs and motions are correct.
Temporal difference learning of N-tuple networks for the game 2048

The highly addictive stochastic puzzle game 2048 has recently invaded the Internet and mobile devices, stealing countless hours of players' lives. In this study we investigate the possibility of creating a game-playing agent capable of winning this game without incorporating human expertise or performing game tree search. For this purpose, we employ three variants of temporal difference learning to acquire i) action value, ii) state value, and iii) afterstate value functions for evaluating player moves at 1-ply. To represent these functions we adopt n-tuple networks, which have recently been successfully applied to Othello and Connect 4. The conducted experiments demonstrate that the learning algorithm using afterstate value functions is able to consistently produce players winning over 97% of games. These results show that n-tuple networks combined with an appropriate learning algorithm have large potential, which could be exploited in other board games.
Lost of Pixel Recovery in Colored Images Using Neural Network

-As we know pixels are lost in colored images due to misfocus of devices, damaged devices, environmental condition and noise. So it is better to have good algorithm to get good quality of image even after de noising that using some algorithm. Many researchers are doing work in this field to recover pixel lost in given RGB image. We are going to present a noble approach for pixel recovery using neural networks to get better result as we know mean and median filter sometimes did not work well with images. Neural networks works on hidden number of layers in that so we use better number of hidden layers to find pixel to its most matching intensity.
The analysis of the chemical components of karst spring Kács and Sály with multivariant statistical methods

Karstic aquifers are very vulnerable sources of groundwater on the Earth. The karst springs of Kács and Sály are important reservoirs, as they provide drinking water for more than 10 settlements in the north-eastern part of Hungary. I monitored these and six other springs for two years. The aim was to know their function and conditions furthermore their relationships with other karst spring in their neighbourhood. In order to explore the relationship with the different karst springs I used cluster analysis.
Sources, Sinks, and Transport of Energetic Electrons Near Saturn's Main Rings

The inner boundary of Saturn's electron radiation belts, near the planet's A ring (∼2.27 Rs), is studied using Cassini's proximal orbit measurements. We find that variable convective flows transport energetic electrons to the A ring, which absorbs them instantaneously, forming the inner belt boundary. These flows are also responsible for a variable and longitudinally asymmetric boundary configuration. Prenoon, the boundary oscillates toward and away from the A ring with a 2‐week period. Postnoon, it maps persistently near the F ring (∼2.32 Rs) and coexists with localized MeV electron intensity enhancements (microbelts). We propose that the microbelts contain electrons in drift resonance with corotation, trapped in local time‐confined trajectories, which result from the aforementioned convective flows. The microbelts' collocation with the F ring implies either a local, secondary electron production due to galactic cosmic ray collisions with F ring dust or an enhanced resonant electron trapping due to an electrodynamic interaction between the F ring and Saturn's magnetosphere.
Propuesta metodológica para el cálculo del riesgo sistémico financiero en estudios de Historia Económica: Aplicación para el caso de la banca libre en Antioquia, 1888

This paper proposes a methodology to calculate the systemic risk in historical research, understanding that the characteristics of non modern financial systems and the availability of information do not enable the use of recent techniques of measuring financial risk. I propose a method of simple application and scarce information requirements, using the degree of leverage as an approximation of the individual risk, and the network theory to determine the allocation of individual risks throughout the system. The methodology is especially useful for studying the banking systems in early corporatizing periods. After been exposed the methodology, which takes as its central axis the shareholders, and the property as base linkages between institutions, it is mentioned its strengths and weaknesses; being, finally, tested in an application for the free banking experience in Antioquia.
Empirical Distribution of the U.S. Housing Market during the Great Recession: Nonlinear Scaling Behavior after a Major Crash

This study focuses on the real estate bubble burst in the US housing market during 2007–2008. We analyze the dynamics of the housing market crash and the after-crash sequence during the Great Recession. When a complex system deviates away from its typical path by the occurrence of an extreme event, its behavior is strongly characterized as nonstationary with higher volatility. With the utilization of a robust method, we present the characteristics of the aftershock period and provide useful information about the spatial distribution and the decay process of the aftershock sequence in terms of time. The returns of the housing price indices are well approximated by the empirics of a power law. Although we deal with low-frequency data, a time power-law relaxation pattern is identified. Our findings align with those in geophysics, indicating that the value of the relaxation parameter typically hovers around one and varies across different thresholds.
Investigative safety science as a competitive advantage for Pharma

Introduction: Following a US National Academy of Sciences report in 2007 entitled “Toxicity Testing of the 21st Century: a Vision and a Strategy,” significant advances within translational drug safety sciences promise to revolutionize drug discovery and development. The purpose of this review is to outline why investigative safety science is a competitive advantage for the pharmaceutical industry. Areas covered: The article discusses the essential goals for modern investigative toxicologists including: cross-species target biology; molecular pathways of toxicity; and development of predictive tools, models and biomarkers that allow discovery researchers and clinicians to anticipate safety problems and plan ways to address them, earlier than ever before. Furthermore, the article emphasizes the importance of investigating unanticipated clinical safety signals through a combination of mechanistic preclinical studies and/or molecular characterization of clinical samples from affected organs. Expert opinion: The traditional boundaries between pharma industry teams focusing on safety/efficacy and preclinical/clinical development are rapidly disappearing in favor of translational safety science-centric organizations with a vision of bringing more effective medicines forward safely and quickly. Comparative biology and mechanistic toxicology approaches facilitate: i) identifying translational safety biomarkers; ii) identifying new drug targets/indications; and iii) mitigating off-target toxicities. These value-adding safety science contributions will change traditional toxicologists from side-effect identifiers to drug development enablers.
Full body human motion estimation on lie groups using 3D marker position measurements

This paper proposes a new algorithm for full body human motion estimation using 3D marker position measurements. The joints are represented with Lie group members, including special orthogonal groups SO(2) and SO(3), and a special euclidean group SE(3). We employ the Lie Group Extended Kalman Filter (LG-EKF) for stochastic inference on groups, thus explicitly accounting for the non-euclidean geometry of the state space, and provide the derivation of the LG-EKF recursion for articulated motion estimation. We evaluate the performance of the proposed algorithm in both simulation and on real-world motion capture data, comparing it with the Euler angles based EKF. The results show that the proposed filter significantly outperforms the Euler angles based EKF, since it estimates human motion more accurately and is not affected by gimbal lock.
Apoptotic marginal zone deletion of anti-Sm/ribonucleoprotein B cells

CD40L is excessively produced in both human and murine lupus and plays a role in lupus pathogenesis. To address how excess CD40L induces autoantibody production, we crossed CD40L-transgenic mice with the anti-DNA H-chain transgenic mouse lines 3H9 and 56R, well-characterized models for studying B-cell tolerance to nuclear antigens. Excess CD40L did not induce autoantibody production in 3H9 mice in which anergy maintains self-tolerance, nor did it perturb central tolerance, including deletion and receptor editing, of anti-DNA B cells in 56R mice. In contrast, CD40L/56R mice restored a large number of marginal zone (MZ) B cells reactive to Sm/ribonucleoprotein (RNP) and produced autoantibody, whereas these B cells were deleted by apoptosis in MZ of 56R mice. Thus, excess CD40L efficiently blocked tolerance of Sm/RNP-reactive MZ B cells, leading to production of anti-Sm/RNP antibody implicated in the pathogenesis of lupus. These results suggest that self-reactive B cells such as anti-Sm/RNP B cells, which somehow escape tolerance in the bone marrow and migrate to MZ, are tolerized by apoptotic deletion in MZ and that a break in this tolerance may play a role in the pathogenesis of lupus.
Emergence of viruses resistant to neutralization by V3-specific antibodies in experimental human immunodeficiency virus type 1 IIIB infection of chimpanzees

Emergence in two chimpanzees of human immunodeficiency virus type 1 (HIV-1) IIIB variants resistant to neutralization by the preexisting antibody is described. Viruses isolated from the HIV-1 IIIB gp120-vaccinated and -challenged animal were more resistant to neutralization by the chimpanzee's own serum than viruses isolated from the naive infected animal, indicating immune pressure as the selective mechanism. However, all reisolated viruses were 16- to 256-fold more neutralization resistant than the inoculum virus to antibodies binding to the third variable domain (V3) of the HIV-1 external envelope. Early chimpanzee serum samples that neutralized the inoculum strain but not the reisolated viruses were found to bind an HIV-1 IIIB common nonapeptide (IQRGPGRAF) derived from the gp120 isolate-specific V3 domain shown to induce isolate-specific neutralization in other animals. Amplification of the V3 coding sequence by polymerase chain reaction and subsequent sequence analysis of the neutralization-resistant variants obtained from in vivo-infected animals indicated that early resistance to neutralization by an HIV-1 IIIB monoclonal antibody (0.5 beta) was conferred by changes outside the direct binding site for the selective neutralizing antibody. The reisolated neutralization-resistant isolates consisted of the lower-replication-competent virus subpopulations of the HIV-1 IIIB stock, as confirmed by biological and sequence analyses. In vitro passage of the HIV-1 IIIB stock through chimpanzee and human peripheral blood mononuclear cell cultures void of HIV-specific antibody resulted in homogenic amplification of the more-replication-competent subpopulation preexisting in the original viral stock, suggesting a role for the immune system in suppressing the more-replication-competent viruses.
Colorectal cancer mortality and factors related to the insulin resistance syndrome.

It has been proposed that hyperinsulinemia is involved in colon carcinogenesis. An association between post-load plasma glucose (PLG) levels and risk of colorectal cancer mortality would be consistent with this hypothesis. We used data from the Chicago Heart Association Detection Project in Industry to examine the associations of nonfasting PLG and other variables related to the insulin resistance syndrome (i.e., systolic blood pressure, body mass index, uric acid, and resting heart rate) with colorectal cancer mortality. After excluding participants reporting a history of diabetes, 191 and 126 colorectal cancer deaths occurred among 20,433 men and 15,149 women, respectively. In multivariate Cox regression analysis, there was a positive relationship between PLG levels and colorectal cancer mortality for women (P for trend = 0.08) but not for men. When men and women were combined, a trend (P = 0.05) for PLG remained. Examination of clustering of insulin resistance syndrome-related risk factors revealed that men with at least 3 of 4 risk factors (i.e., in the highest quartile of the sex-specific distribution for PLG, systolic blood pressure, body mass index, or resting heart rate) had a relative risk (RR) of 1.67 [95% confidence interval (CI), 1.04-2.70] as compared with men who were not in the upper quartile for any of these factors. For women, the RR was 1.29 (95% CI, 0.70-2.37). For men and women combined, the RR was 1.50 (95% CI, 1.03-2.19). These findings provide evidence for a modest association of PLG and insulin resistance syndrome with colorectal cancer mortality and support the insulin hypothesis.
Forgetting Actions in Domain Descriptions

Forgetting irrelevant/problematic actions in a domain description can be useful in solving reasoning problems, such as query answering, planning, conftict resolution, prediction, postdiction, etc. Motivated by such applications, we study what forgetting is, how forgetting can be done, and for which applications forgetting can be useful and how, in the context of reasoning about actions. We study these questions in the action language C (a formalism based on causal explanations), and relate it to forgetting in classical logic and logic programming.
REVIEW: The functional organization of the intraparietal sulcus in humans and monkeys

In macaque monkeys, the posterior parietal cortex (PPC) is concerned with the integration of multimodal information for constructing a spatial representation of the external world (in relation to the macaque's body or parts thereof), and planning and executing object‐centred movements. The areas within the intraparietal sulcus (IPS), in particular, serve as interfaces between the perceptive and motor systems for controlling arm and eye movements in space. We review here the latest evidence for the existence of the IPS areas AIP (anterior intraparietal area), VIP (ventral intraparietal area), MIP (medial intraparietal area), LIP (lateral intraparietal area) and CIP (caudal intraparietal area) in macaques, and discuss putative human equivalents as assessed with functional magnetic resonance imaging. The data suggest that anterior parts of the IPS comprising areas AIP and VIP are relatively well preserved across species. By contrast, posterior areas such as area LIP and CIP have been found more medially in humans, possibly reflecting differences in the evolution of the dorsal visual stream and the inferior parietal lobule. Despite interspecies differences in the precise functional anatomy of the IPS areas, the functional relevance of this sulcus for visuomotor tasks comprising target selections for arm and eye movements, object manipulation and visuospatial attention is similar in humans and macaques, as is also suggested by studies of neurological deficits (apraxia, neglect, Bálint's syndrome) resulting from lesions to this region.
Measuring Molecular, Neutral Atomic, and Warm Ionized Galactic Gas through X-Ray Absorption

We study the column densities of neutral atomic, molecular, and warm ionized Galactic gas through their continuous absorption of extragalactic X-ray spectra at |b|>25°. For NH, 21 cm<5×1020 cm-2, there is an extremely tight relationship between NH, 21 cm and the X-ray absorption column, NH, x, with a mean ratio along 26 lines of sight of NH, x/NH, 21 cm=0.972±0.022. This is significantly less than the anticipated ratio of 1.23, which would occur if He were half He I and half He II in the warm ionized component. We suggest that the ionized component out of the plane is highly ionized, with He being mainly He II and He III. In the limiting case that H is entirely H I, we place an upper limit on the He abundance in the ISM of He/H≤0.103. At column densities NH, x>5×1020 cm-2, which occurs at our lower latitudes, the X-ray absorption column NH, x is nearly double NH, 21 cm. This excess column cannot be due to the warm ionized component even if He were entirely He I, so it must be due to a molecular component. This result implies that for lines of sight out of the plane with |b|~30°, molecular gas is common, with a column density comparable to NH, 21 cm. This work bears upon the far-infrared background, since a warm ionized component, anticorrelated with NH, 21 cm, might produce such a background. Not only is such an anticorrelation absent, but if the dust is destroyed in the warm ionized gas the far-infrared background may be slightly larger than that deduced by Puget and coworkers.
Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene

Embryonic stem cells and induced pluripotent stem cells have the ability to maintain their telomere length via expression of an enzymatic complex called telomerase. Similarly, more than 85%–90% of cancer cells are found to upregulate the expression of telomerase, conferring them with the potential to proliferate indefinitely. Telomerase Reverse Transcriptase (TERT), the catalytic subunit of telomerase holoenzyme, is the rate-limiting factor in reconstituting telomerase activity in vivo. To date, the expression and function of the human Telomerase Reverse Transcriptase (hTERT) gene are known to be regulated at various molecular levels (including genetic, mRNA, protein and subcellular localization) by a number of diverse factors. Among these means of regulation, transcription modulation is the most important, as evident in its tight regulation in cancer cell survival as well as pluripotent stem cell maintenance and differentiation. Here, we discuss how hTERT gene transcription is regulated, mainly focusing on the contribution of trans-acting factors such as transcription factors and epigenetic modifiers, as well as genetic alterations in hTERT proximal promoter.
Star cluster disruption

Abstract Star clusters are often used as tracers of major star-formation events in external galaxies as they can be studied out to much greater distances than individual stars. It is vital to understand their evolution if they are used to derive, for example, the star-formation history of their host galaxy. More specifically, we want to know how cluster lifetimes depend on their environment and on structural properties such as mass and radius. This review presents a theoretical overview of the early evolution of star clusters and the consequent long-term survival chances. It is suggested that clusters forming with initial densities of ≳104 M⊙ pc−3 survive the gas expulsion, or ‘infant mortality,’ phase. At ~10Myr, they are bound and have densities of ~103±1 M⊙ pc−3. After this time, they are stable against expansion through stellar evolution, encounters with giant molecular clouds and will most likely survive for another Hubble time if they are located in a moderate tidal field. Clusters with lower initial densities (≲100 M⊙ pc−3) will disperse into the field within a few 10s of Myrs. Some discussion is given on how extragalactic star cluster populations, and especially their age distributions, can be used to gain insight into disruption.