Miracle-dz/UniFAR-FTUs huggingface dataset:
Highly Sensitive Multi-Channel IDC Sensor Array for Low Concentration Taste Detection

In this study, we designed and developed an interdigitated capacitor (IDC)-based taste sensor array to detect different taste substances. The designed taste sensing array has four IDC sensing elements. The four IDC taste sensing elements of the array are fabricated by incorporating four different types of lipids into the polymer, dioctyl phenylphosphonate (DOPP) and tetrahydrofuran (THF) to make the respective dielectric materials that are individually placed onto an interdigitated electrode (IDE) via spin coating. When the dielectric material of an IDC sensing element comes into contact with a taste substance, its dielectric properties change with the capacitance of the IDC sensing element; this, in turn, changes the voltage across the IDC, as well as the output voltage of each channel of the system. In order to assess the effectiveness of the sensing system, four taste substances, namely sourness (HCl), saltiness (NaCl), sweetness (glucose) and bitterness (quinine-HCl), were tested. The IDC taste sensor array had rapid response and recovery times of about 12.9 s and 13.39 s, respectively, with highly stable response properties. The response property of the proposed IDC taste sensor array was linear, and its correlation coefficient R2 was about 0.9958 over the dynamic range of the taste sensor array as the taste substance concentration was varied from 1 μM to 1 M. The proposed IDC taste sensor array has several other advantages, such as real-time monitoring capabilities, high sensitivity 45.78 mV/decade, good reproducibility with a standard deviation of about 0.029 and compactness, and the circuitry is based on readily available and inexpensive electronic components. The proposed IDC taste sensor array was compared with the potentiometric taste sensor with respect to sensitivity, dynamic range width, linearity and response time. We found that the proposed IDC sensor array has better performance. Finally, principal component analysis (PCA) was applied to discriminate different types of taste of the mixed taste substances.
Modelling empathic behaviour in a robotic game companion for children: An ethnographic study in real-world settings

The idea of autonomous social robots capable of assisting us in our daily lives is becoming more real every day. However, there are still many open issues regarding the social capabilities that those robots should have in order to make daily interactions with humans more natural. For example, the role of affective interactions is still unclear. This paper presents an ethnographic study conducted in an elementary school where 40 children interacted with a social robot capable of recognising and responding empathically to some of the children's affective states. The findings suggest that the robot's empathic behaviour affected positively how children perceived the robot. However, the empathic behaviours should be selected carefully, under the risk of having the opposite effect. The target application scenario and the particular preferences of children seem to influence the “degree of empathy” that social robots should be endowed with.
Contralesional Thalamic Surface Atrophy and Functional Disconnection 3 Months after Ischemic Stroke

Background: Remote structural and functional changes have been previously described after stroke and may have an impact on clinical outcome. We aimed to use multimodal MRI to investigate contralesional subcortical structural and functional changes 3 months after anterior circulation ischemic stroke. Methods: Fifteen patients with acute ischemic stroke had multimodal MRI imaging (including high resolution structural T1-MPRAGE and resting state fMRI) within 1 week of onset and at 1 and 3 months. Seven healthy controls of similar age group were also imaged at a single time point. Contralesional subcortical structural volume was assessed using an automated segmentation algorithm in FMRIB's Integrated Registration and Segmentation Tool (FIRST). Functional connectivity changes were assessed using the intrinsic connectivity contrast (ICC), which was calculated using the functional connectivity toolbox for correlated and anticorrelated networks (Conn). Results: Contralesional thalamic volume in the stroke patients was significantly reduced at 3 months compared to baseline (median change -2.1%, interquartile range [IQR] -3.4-0.4, p = 0.047), with the predominant areas demonstrating atrophy geometrically appearing to be the superior and inferior surface. The difference in volume between the contralesional thalamus at baseline (mean 6.41 ml, standard deviation [SD] 0.6 ml) and the mean volume of the 2 thalami in controls (mean 7.22 ml, SD 1.1 ml) was not statistically significant. The degree of longitudinal thalamic atrophy in patients was correlated with baseline stroke severity with more severe strokes being associated with a greater degree of atrophy (Spearman's rho -0.54, p = 0.037). There was no significant difference between baseline contralesional thalamic ICC in patients and control thalamic ICC. However, in patients, there was a significant linear reduction in the mean ICC of the contralesional thalamus over the imaging time points (p = 0.041), indicating reduced connectivity to the remainder of the brain. Conclusions: These findings highlight the importance of remote brain areas, such as the contralesional thalamus, in stroke recovery. Similar methods have the potential to be used in the prediction of stroke outcome or as imaging biomarkers of stroke recovery.
Newcastle disease virus fusion and haemagglutinin-neuraminidase gene motifs as markers for viral lineage

Reverse transcriptase polymerase chain reaction was used to generate sequence data for 91 Australian Newcastle disease viruses (NDV) isolated from 1932 to 2000 covering the cleavage site of the fusion (F) protein and the C-terminus of the haemagglutinin-neuraminidase (HN) protein. Comparison of sequences at these two sites indicates distinct evolutionary relationships between these viruses. Typically, HN gene relationships revealed by phylogenetic analyses were also maintained in comparisons between F gene cleavage sites; however, the former analyses appeared to give a clearer indication of the lineage of a virus isolate. This data supports and extends earlier observations in that there is no evidence for gene exchange by recombination but that different strains appear to have evolved through synonymous mutations. Inter-relationships, especially between Australian NDV isolates, appear to be associated with lineages having the same C-terminal HN extensions rather than associated with virulence of the virus. A proposed mechanism for this observation is discussed.
Virtual View Synthesis for Free Viewpoint Video and Multiview Video Compression using Gaussian Mixture Modelling

High quality virtual views need to be synthesized from adjacent available views for free viewpoint video and multiview video coding (MVC) to provide users with a more realistic 3D viewing experience of a scene. View synthesis techniques suffer from poor rendering quality due to holes created by occlusion and rounding integer error through warping. To remove the holes in the virtual view, the existing techniques use spatial and temporal correlation in intra/inter-view images and depth maps. However, they still suffer quality degradation in the boundary region of foreground and background areas due to the low spatial correlation in texture images and low correspondence in inter-view depth maps. To overcome the above-mentioned limitations, we use a number of models in the Gaussian mixture modeling (GMM) to separate background and foreground pixels in our proposed technique. Here, the missing pixels introduced from the warping process are recovered by the adaptive weighted average of the pixel intensities from the corresponding GMM model(s) and warped image. The weights vary with time to accommodate the changes due to a dynamic background and the motions of the moving objects for view synthesis. We also introduce an adaptive strategy to reset the GMM modeling if the contributions of the pixel intensities drop significantly. Our experimental results indicate that the proposed approach provides 5.40–6.60-dB PSNR improvement compared with the relevant methods. To verify the effectiveness of the proposed view synthesis technique, we use it as an extra reference frame in the motion estimation for MVC. The experimental results confirm that the proposed view synthesis is able to improve PSNR by 3.15–5.13 dB compared with the conventional three reference frames.
Ultrasound-Mediated Biophotonic Imaging: A Review of Acousto-Optical Tomography and Photo-Acoustic Tomography

This article reviews two types of ultrasound-mediated biophotonic imaging–acousto-optical tomography (AOT, also called ultrasound-modulated optical tomography) and photo-acoustic tomography (PAT, also called opto-acoustic or thermo-acoustic tomography)–both of which are based on non-ionizing optical and ultrasonic waves. The goal of these technologies is to combine the contrast advantage of the optical properties and the resolution advantage of ultrasound. In these two technologies, the imaging contrast is based primarily on the optical properties of biological tissues, and the imaging resolution is based primarily on the ultrasonic waves that either are provided externally or produced internally, within the biological tissues. In fact, ultrasonic mediation overcomes both the resolution disadvantage of pure optical imaging in thick tissues and the contrast and speckle disadvantages of pure ultrasonic imaging. In our discussion of AOT, the relationship between modulation depth and acoustic amplitude is clarified. Potential clinical applications of ultrasound-mediated biophotonic imaging include early cancer detection, functional imaging, and molecular imaging.
Zoom factor compensation for monocular SLAM

SLAM algorithms are widely used in augmented reality applications for registering virtual objects. Most SLAM algorithms estimate camera poses and 3D positions of feature points using known intrinsic camera parameters that are calibrated and fixed in advance. This assumption means that the algorithm does not allow changing the intrinsic camera parameters during runtime. We propose a method for handling focal length changes in the SLAM algorithm. Our method is designed as a pre-processing step for the SLAM algorithm input. In our method, the change of the focal length is estimated before the tracking process of the SLAM algorithm. Camera zooming effects in the input camera images are compensated for by using the estimated focal length change. By using our method, camera zooming can be used in the existing SLAM algorithms such as PTAM [4] with minor modifications. In the experiment, the effectiveness of the proposed method was quantitatively evaluated. The results indicate that the method can successfully deal with abrupt changes of the camera focal length.
Interleukin‐1β and the interleukin‐1 receptor antagonist act in the striatum to modify excitotoxic brain damage in the rat

The cytokine interleukin‐1 (IL‐1) has been implicated in ischaemic, traumatic and excitotoxic brain damage. The results presented here reveal novel actions of IL‐1 in the striatum which markedly exacerbate cortical neuronal damage elicited by local excitotoxins in the striatum or cortex.
Detection of Viral Citrullinated Peptide Antibodies Directed Against EBV or VCP: In Early Rheumatoid Arthritis Patients of Indian Origin

Aim: Study was undertaken to analyze the frequency of anti-viral citrullinated peptide (anti-VCP) antibodies in sera from patients with early rheumatoid arthritis (ERA). Materials and Methods: Viral citrullinated peptide (VCP) and Epstein-Barr nuclear antigen (EBNA-1) peptide were commercially prepared and antibodies to these were determined in 25 patients of ERA, 40 disease control patients constituting 25 rheumatoid arthritis (RA), 7 systemic lupus erythematosus (SLE), 2 scleroderma, 1 spondyloarthritis (SpA), 1 juvenile rheumatoid arthritis (JRA), 1 osteoarthritis (OA), 1 psoriatic arthritis (PsA), 1 undifferentiated arthritis (UA), and 1 gout and 25 healthy controls (HCs) were taken for comparison. In-house ELISA was established for both the antibodies while cyclic citrullinated peptide (CCP) antibody was detected by commercial ELISA kit. Results: Significant increase in VCP antibody by ERA and disease controls than healthy normal was observed. VCP IgM antibody was significantly increased in RA patients than HC. The presence of VCP antibody signifies a good marker for ERA. We observed significant difference in the VCP IgG and IgM antibody when compared to EBNA-1. In-house ELISA established for EBNA-1 and VCP antibodies showed low sensitivity but 96% specificity. Conclusions: We observed that sera from early RA patients reacted to the deiminated protein encoded by Epstain Barr Virus (EBV). Thus a possible role of virus in inducing an anti-citrullinated peptide antibody (ACPA) response reveals viral etiology in this disease.
Building Damage Estimation by Integration of Seismic Intensity Information and Satellite L-band SAR Imagery

For a quick and stable estimation of earthquake damaged buildings worldwide, using Phased Array type L-band Synthetic Aperture Radar (PALSAR) loaded on the Advanced Land Observing Satellite (ALOS) satellite, a model combining the usage of satellite synthetic aperture radar (SAR) imagery and Japan Meteorological Agency (JMA)-scale seismic intensity is proposed. In order to expand the existing C-band SAR based damage estimation model into L-band SAR, this paper rebuilds a likelihood function for severe damage ratio, on the basis of dataset from Japanese Earth Resource Satellite-1 (JERS-1)/SAR (L-band SAR) images observed during the 1995 Kobe earthquake and its detailed ground truth data. The model which integrates the fragility functions of building damage in terms of seismic intensity and the proposed likelihood function is then applied to PALSAR images taken over the areas affected by the 2007 earthquake in Pisco, Peru. The accuracy of the proposed damage estimation model is examined by comparing the results of the analyses with field investigations and/or interpretation of high-resolution satellite images.
Chapter Ii. Splines with Uniform Knots

draft jul74, T E Xed 1997 Carl de Boor 1. Specialization to the knot sequence Z 2. Cardinal spline interpolation 3. The exponential splines 4. Cardinal spline interpolation as the degree goes to infinity 5. Approximation of cardinal type 6. Semicardinal
Lifelong exercise and stroke.

OBJECTIVES--To examine the potential of lifelong patterns of increased physical activity to prevent stroke. DESIGN--Case-control study. SETTING--11 general practices in west Birmingham. SUBJECTS--125 men and women who had just had their first stroke and were aged 35-74 and 198 controls frequency matched for age and sex recruited over 24 months during 1988-90. Exclusion criteria were a previous history of stroke, mitral valvular heart disease combined with atrial fibrillation, primary or metastatic cerebral neoplasm, or coagulation disorder or myeloproliferative disease. MAIN OUTCOME MEASURES--Odds ratios for stroke related to lifetime history of exercise after 15 years of age. RESULTS--A history of vigorous exercise during the ages 15-25 appeared to protect from stroke: odds ratio adjusted for age and sex 0.33 (95% confidence interval 0.2 to 0.6). This effect was independent of other potential risk factors. Increasing years of participation in vigorous exercise between the ages of 15 and 55 produced an increasing protection from stroke (p < 0.001). In the 65 cases and 169 controls who were free of cardiac ischaemia, peripheral vascular disease, and poor health recent vigorous exercise and walking were protective against stroke: odds ratios of 0.41 (0.2 to 1.0) for recent vigorous exercise and 0.30 (0.1 to 0.7) for recent walking. CONCLUSIONS--Appreciable protection from stroke in later life is conferred by vigorous exercise in early adulthood. This increased level of physical activity should, if possible, be continued lifelong.
The R Enantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis

ABSTRACT The novel nitroimidazopyran agent (S)-PA-824 has potent antibacterial activity against Mycobacterium tuberculosis in vitro and in vivo and is currently in phase II clinical trials for tuberculosis (TB). In contrast to M. tuberculosis, where (R)-PA-824 is inactive, we report here that both enantiomers of PA-824 show potent parasiticidal activity against Leishmania donovani, the causative agent of visceral leishmaniasis (VL). In leishmania-infected macrophages, (R)-PA-824 is 6-fold more active than (S)-PA-824. Both des-nitro analogues are inactive, underlining the importance of the nitro group in the mechanism of action. Although the in vitro and in vivo pharmacological profiles of the two enantiomers are similar, (R)-PA-824 is more efficacious in the murine model of VL, with >99% suppression of parasite burden when administered orally at 100 mg kg of body weight−1, twice daily for 5 days. In M. tuberculosis, (S)-PA-824 is a prodrug that is activated by a deazaflavin-dependent nitroreductase (Ddn), an enzyme which is absent in Leishmania spp. Unlike the case with nifurtimox and fexinidazole, transgenic parasites overexpressing the leishmania nitroreductase are not hypersensitive to either (R)-PA-824 or (S)-PA-824, indicating that this enzyme is not the primary target of these compounds. Drug combination studies in vitro indicate that fexinidazole and (R)-PA-824 are additive whereas (S)-PA-824 and (R)-PA-824 show mild antagonistic behavior. Thus, (R)-PA-824 is a promising candidate for late lead optimization for VL and may have potential for future use in combination therapy with fexinidazole, currently in phase II clinical trials against VL.
Spatial-Temporal Analysis of Face Processing Using an ERP Study of the Thatcher Illusion

A face with the inversion of eyes and mouth relative to the rest parts of the face looks grotesque when viewed upright but not when viewed upside down, which is called "the Thatcher illusion". Brain studies indicate that this is caused by the disruption of facial information processing. However, the neural mechanism of the face processing is still ambiguous. In the current study, we investigated neural correlates of featural and configural processing in faces using a spatial-temporal analysis of event-related potentials (ERP). The results showed that the PI component was affected by face inversion but not by Thatcherization. For the N170 component, the inversion effect was salient while the Thatcherization effect interacted with orientation and hemisphere. A bilaterally distributed effect of Thatcherization was observed in inverted faces and a contrary difference was showed in upright faces. This indicated that the perceptual effect of Thatcher illusion does not parallel N170 component. Combining with the scalp topographies we come to a conclusion that the left occipito-temporal area of the brain is sensitive to featural information of visual face stimuli while the right area is sensitive to configural information.
The role of intraoperative interventions to minimise chronic postsurgical pain

Chronic postsurgical pain (CPSP) is the most common complication following surgery, with increasing evidence of both its prevalence and severity. While awareness of the various risk factors for this long-term condition is also increasing, effective prevention remains elusive. In this review, we describe the increasing evidence for preventive or ‘protective’ strategies. Controversies and conflicting human data are presented along with suggestions for improved future study.
Tuberculosis case fatality rates in high HIV prevalence populations in sub-Saharan Africa

BackgroundTuberculosis is a leading cause worldwide of morbidity and mortality among HIV-infected people. The HIV era has seen a dramatic increase of the tuberculosis case fatality rate (CFR) in high HIV prevalence populations. Providing care for HIV-infected people must include measures to tackle this high tuberculosis CFR. AimsTo analyse the extent of the increased tuberculosis CFR in high HIV prevalence populations in sub-Saharan Africa, the reasons for this increase and the causes of death, in order to identify possible ways of tackling this problem. MethodsReferences were obtained by searching the MEDLINE on ‘tuberculosis', ‘HIV infection', and ‘mortality’ (MesH or textword). In addition, available data from National Tuberculosis Programme reports were reviewed. FindingsTuberculosis CFR is closely linked to HIV prevalence. Limited autopsy data suggest that death from HIV-related diseases other than tuberculosis is probably the main reason for the increased CFR in HIV-infected tuberculosis patients. Among HIV-infected tuberculosis patients, the higher tuberculosis CFR in sputum smear-negative and extrapulmonary than in sputum smear-positive tuberculosis cases can also be attributed to misdiagnosis of HIV-related diseases as tuberculosis. The adverse effect of the HIV/AIDS epidemic on general health service performance probably accounts for the higher tuberculosis CFR among HIV-negative tuberculosis patients in high prevalence populations than that in low HIV-prevalence populations. ConclusionTackling the problem of the increased tuberculosis CFR in high HIV prevalence populations requires collaboration between tuberculosis control and HIV/AIDS programmes in implementing measures such as improved health services, tuberculosis and HIV control services, preventive treatment for HIV-related diseases and anti-HIV treatment.
Cross-cultural adaptation and validation of the Quebec User Evaluation of Satisfaction with Assistive Technology (QUEST 2.0): the development of the Taiwanese version

Objective: To develop and validate a cross-cultural version of the Quebec User Evaluation of Satisfaction with Assistive Technology (QUEST 2.0) for users of assistive technology devices in Taiwan. Design: A cross-sectional survey. Procedures: The standard cultural adaptation procedure was used for questionnaire translation and cultural item design. A field test was then conducted for item selection and psychometric properties testing. Subjects: One hundred and five volunteer assistive device users in community. Main outcome measures: A questionnaire comprising 12 items of the QUEST 2.0 and 16 culture-specific items. Results: One culture-specific item, ‘Cost’, was selected based on eight criteria and added to the QUEST 2.0 (12 items) to formulate the Taiwanese version of QUEST 2.0 (T-QUEST). The T-QUEST consisted of 13 items which were classified into two domains: device (8 items) and service (5 items). The internal consistencies of the device, service and total T-QUEST scores were 0.87, 0.84 and 0.90, respectively. The device, services and total T-QUEST scores achieved good test-retest stability (intraclass correlation coefficient (ICC) 0.90, 0.97, 0.95). Exploratory factor analysis revealed that T-QUEST had a two-factor structure for device and service in the construct of user satisfaction (53.42% of the variance explained). Conclusions: Users of assistive device in different culture may have different concerns regarding satisfaction. T-QUEST is the first published version of QUEST with culture-specific items added to the original translated items of QUEST 2.0. T-QUEST was a valid and reliable tool for measuring user satisfaction among Mandarin-speaking individuals using various kinds of assistive devices.