Miracle-dz/UniFAR-FTUs huggingface dataset:
Bovine Milk and Yogurt Affect Oral Microorganisms and Biofilms In-Vitro.

PURPOSE To evaluate the effect of bovine milk and yogurt on selected oral microorganisms and different oral biofilms. MATERIALS AND METHODS Milk was prepared from 0.5% fat (low-fat) and 16% fat (high fat) milk powder. For yogurt preparation, the strains Lactobacillus delbrueckii ssp. bulgarcius and Streptococcus thermophilus were added to the milk. Minimal inhibitory concentrations (MIC) and minimal microbiocidal concentrations (MMC) of the test compounds were measured against various microorganisms by the microbroth dilution technique. Cariogenic periodontal biofilms and one containing Candida were created on plastic surfaces coated with test substances. Further, preformed biofilms were exposed to the test substances at a concentration of 100% for 10 min and thereafter 10% for 50 min. Both colony forming units (cfu) and metabolic activity were quantified in the biofilms. RESULTS Neither high-fat milk, low-fat milk nor casein inhibited the growth of any species. Yogurt and L. delbrueckii ssp. bulgaricus at low MIC and MMC suppressed the growth of Porphyromonas gingivalis and other bacteria associated with periodontal disease. High-fat yogurt decreased cfu in the forming periodontal biofilm by 90%. Both low- and high-fat yogurts reduced metabolic activity in newly forming and preformed periodontal and Candida biofilms, but not in the cariogenic biofilm. CONCLUSIONS Yogurt and L. delbru eckii ssp. bulgaricus, but not milk, were bactericidal against periodontopathogenic bacteria. Yoghurt reduced the metabolic activity of a Candida biofilm and a periodontal biofilm. Yogurt and L. delbrueckii ssp. bulgaricus may have potential in prevention and therapy of periodontal diseases and Candida infections.
Electrostatic modification of novel materials

Application of the field-effect transistor principle to novel materials to achieve electrostatic doping is a relatively new research area. It may provide the opportunity to bring about modifications of the electronic and magnetic properties of materials through controlled and reversible changes of the carrier concentration without modifying the level of disorder, as occurs when chemical composition is altered. As well as providing a basis for new devices, electrostatic doping can in principle serve as a tool for studying quantum critical behavior, by permitting the ground state of a system to be tuned in a controlled fashion. In this paper progress in electrostatic doping of a number of materials systems is reviewed. These include structures containing complex oxides, such as cuprate superconductors and colossal magnetoresistive compounds, organic semiconductors, in the form of both single crystals and thin films, inorganic layered compounds, single molecules, and magnetic semiconductors. Recent progress in the field is discussed, including enabling experiments and technologies, open scientific issues and challenges, and future research opportunities. For many of the materials considered, some of the results can be anticipated by combining knowledge of macroscopic or bulk properties and the understanding of the field-effect configuration developed during the course of the evolution of conventional microelectronics. However, because electrostatic doping is an interfacial phenomenon, which is largely an unexplored field, real progress will depend on the development of a better understanding of lattice distortion and charge transfer at interfaces in these systems.
Visual recognition and prediction analysis of China’s real estate index and stock trend based on CNN-LSTM algorithm optimized by neural networks

Today, with the rapid growth of Internet technology, the changing trend of real estate finance has brought great an impact on the progress of the social economy. In order to explore the visual identification (VI) effect of Convolutional Neural Network and Long Short-Term Memory (CNN-LSTM) algorithm based on neural network optimization on China’s real estate index and stock trend, in this study, artificial neural network (ANN) algorithm is introduced to predict its trend. Firstly, LSTM algorithm can effectively solve the problem of vanishing gradient, which is suitable for dealing with the problems related to time series. Secondly, CNN, with its unique fine-grained convolution operation, has significant advantages in classification problems. Finally, combining the LSTM algorithm with the CNN algorithm, and using the Bayesian Network (BN) layer as the transition layer for further optimization, the CNN-LSTM algorithm based on neural network optimization has been constructed for the VI and prediction model of real estate index and stock trend. Through the performance verification of the model, the results reveal that the CNN-LSTM optimization algorithm has a more accurate prediction effect, the prediction accuracy is 90.55%, and the prediction time is only 52.05s. At the same time, the significance advantage of CNN-LSTM algorithm is verified by statistical method, which can provide experimental reference for intelligent VI and prediction of trend of China real estate index and property company stocks.
Sex differences in long-term survival after intensive care unit treatment for sepsis: A cohort study

Objective To determine the effect of sex on sepsis-related ICU admission and survival for up to 3-years. Methods Retrospective cohort study of adults admitted to Australian ICUs between 2018 and 2020. Men and women with a primary diagnosis of sepsis were included. The primary outcome of time to death for up to 3-years was examined using Kaplan Meier plots. Secondary outcomes included the duration of ICU and hospital stay. Results Of 523,576 admissions, there were 63,039 (12·0%) sepsis-related ICU admissions. Of these, there were 50,956 patients (43·4% women) with 3-year survival data. Men were older (mean age 66·5 vs 63·6 years), more commonly received mechanical ventilation (27·4% vs 24·7%) and renal replacement therapy (8·2% vs 6·8%) and had worse survival (Hazard Ratio [HR] 1·11; 95% Confidence Interval [CI] 1·07 to 1·14, P<0·001) compared to women. The duration of hospital and ICU stay was longer for men, compared to women (median hospital stay, 9.8 vs 9.4 days; p<0.001 and ICU stay, 2.7 vs 2.6 days; p<0.001). Conclusion Men are more likely to be admitted to ICU with sepsis and have worse survival for up to 3-years. Understanding causal mechanisms of sex differences may facilitate the development of targeted sepsis strategies.
A bar-joint model based on the corrected resistive force theory for artificial flagellated micro-swimmers propelled by acoustic waves

In this work, we proposed a bar-joint model based on the corrected resistive force theory (CRFT) for studying artificial flagellated micro-swimmers (AFMSs) propelled by acoustic waves in a two-dimensional (2D) flow field or with a rectangular cross-section. Note that the classical resistive-force theory for 3D cylindrical flagellum leads to over 90% deviation in terminal velocity from those of 2D fluid-structure interaction (FSI) simulations, while the proposed CRFT bar-joint model can reduce the deviation to below 5%; hence, it enables a reliable prediction of the 2D locomotion of an acoustically actuated AFMS with a rectangular cross-section, which is the case in some experiments. Introduced in the CRFT is a single correction factor K determined by comparing the linear terminal velocities under acoustic actuation obtained from the CRFT with those from simulations. After the determination of K, detailed comparisons of trajectories between the CRFT-based bar-joint AFMS model and the FSI simulation were presented, exhibiting an excellent consistency. Finally, a numerical demonstration of the purely acoustic or magneto-acoustic steering of an AFMS based on the CRFT was presented, which can be one of the choices for future AFMS-based precision therapy.
Dust in brown dwarfs - I. Dust formation under turbulent conditions on microscopic scales

Dust formation in turbulent media is studied adopting the example of brown dwarf atmospheres. By combining asymptotic techniques and time-dependent, multi-dimensional numerical simulations, we show that acoustic waves originating from convective motions provide a mechanism to initiate dust nucleation in otherwise dust-hostile environments. The subsequently growing particles cause a radiative cooling strong enough to re-initiate efficient dust formation resulting in a strongly inhomogeneous distribution of dust in such environments. Recent observations bear indications for such cloudy dust distributions in brown dwarf atmospheres.
Phylogenetic placement of the protosteloid amoeba Microglomus paxillus identifies another case of sporocarpic fruiting in Discosea (Amoebozoa)

Protosteloid amoebae are a paraphyletic assemblage of amoeboid protists found exclusively in the eukaryotic assemblage Amoebozoa. These amoebae can facultatively form a dispersal structure known as a fruiting body, or more specifically, a sporocarp, from a single amoeboid cell. Sporocarps consist of one to a few spores atop a noncellular stalk. Protosteloid amoebae are known in two out of three well‐established major assemblages of Amoebozoa. Amoebae with a protosteloid life cycle are known in the major Amoebozoa lineages Discosea and Evosea but not in Tubulinea. To date, only one genus, which is monotypic, lacks sequence data and, therefore, remains phylogenetically homeless. To further clarify the evolutionary milieu of sporocarpic fruiting we used single‐cell transcriptomics to obtain data from individual sporocarps of isolates of the protosteloid amoeba Microglomus paxillus. Our phylogenomic analyses using 229 protein coding markers suggest that M. paxillus is a member of the Discosea lineage of Amoebozoa most closely related to Mycamoeba gemmipara. Due to the hypervariable nature of the SSU rRNA sequence we were unable to further resolve the phylogenetic position of M. paxillus in taxon rich datasets using only this marker. Regardless, our results widen the known distribution of sporocarpy in Discosea and stimulate the debate between a single or multiple origins of sporocarpic fruiting in Amoebozoa.
Cemented vs Uncemented hemiarthroplasties for femoral neck fractures: An overlapping systematic review and evidence appraisal

Background The purpose of our study is to assess the methodology of overlapping systematic reviews related to cemented vs uncemented hip hemiarthroplasties for the treatment of femoral neck fractures to find the study with the best evidence. Also, we assess the gaps in methodology and information to help with direction of future studies. Methods A systematic search was conducted in September 2022 using Pubmed, Embase, and Cochrane Library. Clinical outcome data and characteristics of each study were extracted to see which treatment had better favorability. The outcomes and characteristics extracted from each study includes, first author, search date, publication journal and date, number of studies included, databases, level of evidence, software used, subgroup analyses that were conducted, and heterogeneity with the use of I2 statistics Methodological quality information was extracted from each study using four different methodologic scores (Oxford Levels of Evidence; Assessment of Multiple Systematic Reviews (AMSTAR); Quality of reporting of meta-analyses (QUROM); Oxman and Guyatt. After that, the Jadad decision algorithm was used to identify which studies in our sample contained the best available evidence. Finally, overlap of each systematic review was assessed using Corrected Covered Area (CCA) to look at redundancy and research waste among the systematic reviews published on the topic. Results After screening, 12 studies were included in our sample. For the Oxford Levels of Evidence, we found that all the studies were Level I evidence. For the QUORUM assessment, we had 1 study with the highest score of 18. Additionally, we did the Oxman and Guyatt assessment, where we found 4 studies with a maximum score of 6. Finally, we did an AMSTAR assessment and found 2 studies with a score of 9. After conducting the methodological scores; the authors determined that Li. L et al 2021 had the highest quality. In addition, it was found that the CCA found among the primary studies in each systematic review calculated to . 22. Any CCA above . 15 is considered “very high overlap”. Conclusions The best available evidence suggests that Cemented HAs are better at preventing Prosthesis-related complications. Conversely, the best evidence also suggests that Cemented HA also results in longer operative time and increased intraoperative blood loss. When conducting future systematic reviews related to the topic, we ask that authors restrict conducting another systematic review until new evidence emerges so as not to confuse the clinical decision-making of physicians.
The Burden of having to Wonder: Hospice Caregiving Experiences of LGBTQ+ Cancer Family Caregivers

Background and Objectives LGBTQ+ people are more likely to be caregivers for family and friends with life-limiting illnesses than non-LGBTQ+ people. LGBTQ+ caregivers may also experience stigma, bias, and discrimination, in addition to caregiving stress. Yet few studies have elicited LGBTQ+ family caregivers’ perspectives on their end-of-life (EOL) experiences of home hospice. Research Design and Methods We conducted semi-structured interviews with LGBTQ+ family caregivers of home hospice patients (N = 20). Following an interpretive descriptive approach, interview data were audio recorded, transcribed, and iteratively coded, and themes were developed and synthesized. Results The burden of having to wonder expressed caregivers’ uncertainty and concern about whether their negative experiences were common to all EOL caregivers or stemmed from cultural stigma and provider bias. Participants described how invisibility vs. risks of disclosure, anticipatory anxiety, perceived microaggressions, and protective vigilance increased stress and complicated caregiver-provider communication. Navigating EOL universalities vs. minority realities depicted underlying tensions between commonly assumed universalities of EOL caregiving and LGBTQ+-specific experiences. Providers’ discomfort, awkward communication, lack of access to culturally competent EOL support resources, and broader structural and cultural discrimination eroded their sense of connectedness and safety. Together, these themes characterized the impact of minority stress at EOL. Discussion and Implications Our findings suggest that LGBTQ+ hospice caregivers are at risk for minority stress in addition to more common sources of EOL caregiving pressures and thus have specific support and communication needs. Providers must understand this to deliver effective EOL care for all families.
Considerations in the Selection of Global Climate Models for Regional Climate Projections: The Arctic as a Case Study*

Abstract Climate projections at regional scales are in increased demand from management agencies and other stakeholders. While global atmosphere–ocean climate models provide credible quantitative estimates of future climate at continental scales and above, individual model performance varies for different regions, variables, and evaluation metrics—a less than satisfying situation. Using the high-latitude Northern Hemisphere as a focus, the authors assess strategies for providing regional projections based on global climate models. Starting with a set of model results obtained from an “ensemble of opportunity,” the core of this procedure is to retain a subset of models through comparisons of model simulations with observations at both continental and regional scales. The exercise is more one of model culling than model selection. The continental-scale evaluation is a check on the large-scale climate physics of the models, and the regional-scale evaluation emphasizes variables of ecological or societal rele.
Terahertz pulse imaging of in-vitro basal cell carcinoma samples

Summary form only given. The use of Terahertz Pulse Imaging (TPI) for the analysis of skin cancer has been investigated. Our initial experiments have focused on the analysis of basal cell carcinoma (BCC), the most common form of skin cancer. BCC seldom metastasize but can be locally very invasive. The current diagnosis of carcinomas is by visual examination, where suspicious lesions require biopsy and subsequent histological diagnosis, which is painful, time consuming and may require additional tissue removal. The use of TPI as a diagnostic tool for skin cancer is of particular interest as its long wavelengths lead to a reduction in Rayleigh scattering and a resultant axial resolution of approximately 80 /spl mu/m. The spectroscopic information of TPI may prove to be advantageous in the discrimination between tumor types, which is unattainable using other methods such as ultrasound. Through the use of TPI, unnecessary biopsies could be avoided, by providing in-vivo measurements before surgery to identify the type and depth of tumor present.
Health status and quality of life in comorbid physical multimorbidity and depression among adults aged ⩾50 years from low- and middle-income countries

Background: Data on the clinical and functional significance of comorbid depression in physical multimorbidity in middle-aged and older adults and from low- and middle-income countries (LMICs) are lacking. Aims: This study aims to determine the association of comorbid depression in physical multimorbidity with health outcomes and quality of life among adults aged ⩾50 years from six LMICs. Methods: Cross-sectional, nationally representative data from the Study on Global Ageing and Adult Health were analyzed. DSM-IV Depression was based on past 12-month symptoms. Eleven chronic physical conditions were assessed. Health status was based on scales ranging from 0 (best) to 100 (worse). The quality of life (8-item WHO Quality of Life) scale ranged from 0 (worse) to 100 (best). Multivariable linear regression analyses were conducted. Results: Data on 34,129 individuals aged ⩾50 years [mean (SD) age 62.4 (16.0) years; 52.1% females] were analyzed. Among people with physical multimorbidity, having comorbid depression was associated with significantly worse health status in terms of sleep/energy (β = 14.71: 95% CI [12.23, 17.20]), self-care (13.23: [8.66, 17.82]), pain/discomfort (13.03: [9.59, 16.47]), mobility (11.06: [6.91, 15.21]), cognition (10.41: [7.31, 13.50]), perceived stress (8.35: [4.71, 11.99]), interpersonal activities (7.81: [3.71, 11.91]), and lower quality of life (−8.81: [−10.74, −6.88]). Conclusions: Comorbid depression in physical multimorbidity was associated with lower quality of life and poorer scores in multiple domains of health status. Treatment of depression in people with physical multimorbidity may potentially lead to better clinical outcomes, but future studies are needed to determine the most effective intervention to address this comorbidity in LMICs.
Effect of relative humidity on friction behavior of the head/disk interface

The effect of relative humidity on friction behavior of the head-disk interface was investigated experimentally. The thickness of adsorbed water on both head and disk surfaces was measured at various relative humidities using an ellipsometer. Lubricated disks adsorbed less water than unlubricated disks, and an optimal thickness of lubricant was found for the least water adsorption. It was found that total liquid thickness (lubricant and adsorbed water) on both contacting surfaces was better correlated with static friction coefficient compared with total liquid thickness on the disk surfaces only or total water thickness only at the head-disk interface. >
ON THE PRINCIPLE OF CONTROLLED L∞ CONVERGENCE IMPLIES ALMOST EVERYWHERE CONVERGENCE FOR GRADIENTS

Let Ω ⊂ ℝn be a bounded open set. If a sequence fk : Ω → ℝN converges to f in L∞ in a certain "controlled" manner while bounded in W1,p (1 < p < + ∞) or BV, we show that f ∈ W1,p (respectively, f ∈ BV) and ∇fk → ∇f almost everywhere, where ∇fk and ∇f are the usual gradients if fk ∈ W1,p (respectively, the absolutely continuous part of the gradient measures if fk ∈ BV). Our main theorem generalizes results for Lipschitz mappings. We show by an example that when p = 1, the limit of a sequence of increasing functions may fail to be in W1,1 and can even be nowhere C1.
Validity of the International Physical Activity Questionnaire (short form) in adults with asthma

Background The short form of the International Physical Activity Questionnaire (IPAQ) is widely used to assess PA and has already been used in adults with asthma; however, its validity has not been yet studied in this population. Therefore, the aim of this study was to verify the convergent and discriminative validity of the IPAQ short form in adults with asthma. Methods Fifty-three adults with asthma (36 females; 48±15 years; 29±6 kg/m²) wore the triaxial activity monitor Actigraph for eight days to objectively measure steps/day, time in light physical activity (PA), moderate-to-vigorous PA (MVPA), and sedentary behaviour. Participants filled out the IPAQ matching with the same week they wore the Actigraph, with measures of: time of MVPA and total PA/week; categorization of low, moderate or high PA level; time in seated position. Results IPAQ self-reported total time of PA/week was weakly correlated with steps/day. The IPAQ categorization correlated moderately with time in light, MVPA and steps/day. Self-reported time in seated position on weekdays was moderately correlated with objective percentage/day of time in sedentary behaviour in the same period. IPAQ categorization in PA levels was able to differentiate between low to moderate and low to high PA levels. Conclusions These results cannot confidently infer the convergent validity of the IPAQ to quantify number of steps/day and time spent in PA of adults with asthma. However, this instrument may be useful to categorize patients into three levels of PA.
Heterogeneous Behavior after Yielding of Solid Suspensions

A method of visualizing the temporal changes in the deformation of suspensions simultaneously with rheological measurements was developed. The observed heterogeneity can only be identified by visual means. The diverse results which can normally be obtained only by stress measurements can be explained with the aid of visualization results, thus remarkably contributing to the understandings of the difficult rheological mechanism involved. The following major findings were obtained. It was reconfirmed that suspensions are statistically solid bodies. An initial yielding is difficult to detect unless by visual means. The characteristic properties of the solid body are either a limiting strain within which the suspension behaves as an elastic body (for Na‐bentonite, for example) or a static yield (for kaolin in water, etc.). The former could be recognized to have some binding force between particle and liquid. After yielding, the stress continues to increase, but at slow rotation velocity, deformation begins to.