Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence of systemic diseases among patients requesting dental consultation in the public and private systems

Objectives: To determine the prevalence and aetiology of systemic disease among patients requesting dental treatment in public and private practice. Study Design: A retrospective analysis was performed of the medical histories of 2000 patients requesting dental treatment during the year 2009. One thousand patients came from the Fontiñas Primary Care Oral and Dental Health Unit of the Galician Health Service (SERGAS), Spain, and the other thousand from a private clinic; both clinics were situated in Santiago de Compostela, La Coruña, Spain. The data collected were the following: demographic data (age and sex), presence or absence of systemic diseases and the nosologic categories, and drug history (type and number of drugs). Results: The prevalence of systemic disease was significantly higher among patients seen in the public system (35.2% in the public system versus 28.1% in the private system; p= 0.003). The differences between the two systems were more marked when considering patients aged under 65 years, particularly with respect to rheumatic and endocrine-metabolic (diabetes) disorders. The prevalence of patients receiving polypharmacy (>4 drugs/day) was significantly higher among patients seen in the public system (5.7% in the public system versus 2.7% in the private system; p= 0.009). Conclusions: There is a high prevalence of medical disorders and of patients receiving polypharmacy among individuals requesting dental care, particularly in the public health system. Dentists must have adequate training in medical disease and must be fully integrated into primary care health teams in order to prevent or adequately resolve complications. Key words: Dentistry, medical history, systemic disease, polypharmacy.
Detection of left ventricular hypertrophy by multichannel magnetocardiography

Left ventricular hypertrophy (LVH) is a powerful independent risk factor for cardiac morbidity and mortality [1]. Although LVH itself may be symptomless, its detection is likely to contribute to the treatment of the patient. Thus, the detection of LVH is a clinical priority. The most widely used methods for detecting LVH are 12-lead electrocardiography (ECG) and echocardiography. The ECG criteria for LVH, however, have low sensitivity at clinically acceptable levels of specificity [2]. Echocardiography, on the other hand, suffers from interobserver and intraobserver variability [3]. Only a few studies have been published on detecting LVH by magnetocardiography (MCG) [4, 5, 6, 7]. The changes, on which the diagnosis of LVH by ECG is based, are an increase in duration and amplitude of the QRS complex due to an increase in LV mass [8], and abnormalities in ventricular repolarization [9]. Vectorcardiographic QRSand T-loops, which in normal hearts tend to be parallel, are typically more divergent in LVH. In ECG this change can be seen as so-called LV strain pattern, i.e., downsloping convex ST-segment, which evolves into an asymmetrical inverted T-wave, see Fig. 1. [8] In a normal heart, the main direction of ventricular activation is radial. In a hypertrophied heart, the contribution of tangential currents is increased. MCG is pri-
CGRP antagonist infused into the bed nucleus of the stria terminalis impairs the acquisition and expression of context but not discretely cued fear

Calcitonin gene-related peptide (CGRP) infusions into the bed nucleus of the stria terminalis (BNST) evoke increases in startle amplitude and increases in anxiety-like behavior in the plus maze. Conversely, intra-BNST infusions of the CGRP antagonist CGRP8–37 block unconditioned startle increases produced by fox odor. Here we evaluate the contribution of CGRP signaling in the BNST to the development and expression of learned fear. Rats received five pairings of a 3.7-sec light and footshock and were tested for fear-potentiated startle one or more days later. Neither pre-training (Experiment 1) nor pre-test (Experiment 2) infusions of the CGRP antagonist CGRP8–37 (800 ng/BNST) disrupted fear-potentiated startle to the 3.7-sec visual cue. However, in both experiments, CGRP8–37 infusions disrupted baseline startle increases that occurred when rats were tested in the same context as that in which they previously received footshock (Experiment 3). Intra-BNST CGRP8–37 infusions did not disrupt shock-evoked corticosterone release (Experiment 4). These data confirm previous findings implicating BNST CGRP receptors in fear and anxiety. They extend those results by showing an important contribution to learned fear and, specifically, to fear evoked by a shock-associated context rather than a discrete cue. This pattern is consistent with previous models of BNST function that have posited a preferential role in sustained anxiety as opposed to phasic fear responses. More generally, the results add to a growing body of evidence indicating behaviorally, possibly clinically, relevant modulation of BNST function by neuroactive peptides.
TEM: a therapeutic exercise machine for the lower extremities of spastic patients

The Therapeutic Exercise Machine (TEM) is a newly developed exercise machine which aims to help stroke patients to recover their walking function using kinetic therapy on the lower extremities. The TEM functions by moving the lower extremities using two mechanical arms. These arms are driven by electric motors and controlled by a computer using load sensor information. TEM attempts to copy and re-enact therapists' techniques in moving legs and also employs a measurement function to monitor the patient's condition. TEM has a function to perform compliant motion as is normally performed by a therapist by hand. Therefore, TEM can accomplish the evaluation of a therapist's technique that is not available for conventional machines. In this paper, the effects of compliant motion against an impulsive load are shown, and the short-term effects of a continuous, passive, range-of-motion exercise (CPROM-E) in spastic patients and normal subjects are observed. In the normal subjects, the peak torque of the hip decreased steadily and significantly by about 5% after CPROM-E, although the peak amplitude of the surface integrated-electromyogram (I-EMG) was not always reduced. In the spastic patients, the peak torque of the hip decreased significantly, by about 35%, and the peak amplitudes of I-EMG also decreased significantly. These results suggest the TEM could make relax spasticity and reduce the level of I-EMG.
Polymorphic microsatellite loci from the western corn rootworm (Insecta: Coleoptera: Chrysomelidae) and cross-amplification with other Diabrotica spp

The northern corn rootworm (Diabrotica barberi) and Mexican corn rootworm (Diabrotica virgifera zeae) are significant agricultural pests. For the northern corn rootworm, and to a lesser extent, the Mexican corn rootworm, high resolution molecular markers are needed. Here we present 14 polymorphic microsatellite loci isolated from libraries constructed using pooled northern and Mexican corn rootworm genomic DNA. Polymorphism in other Diabrotica, including the banded cucumber beetle, southern corn rootworm and western corn rootworm, is described.
Loss and Grief Issues in Addiction and Recovery

ABSTRACT This article examines loss and grief issues involved in addiction and recovery. Tracing first the role that unresolved grief can play as a precursor to substance abuse and addiction, the author then explores aspects of grief that are a part of the disease and recovery process for both the addict and the family system of the addict. Although little has been written about grief as it relates to addiction, it is a major factor for all who are affected by the disease. Treatment programs and twelve step groups need to be aware of this, and be sensitive to the need for the “grief work,” of both the addicted and their families.
The p38–PGC-1α–irisin–betatrophin axis

The discovery of irisin as a novel and promising peptidic hormone has raised hopes regarding the hypothesis that irisin may provide additional benefits, not only for obesity and diabetes, but also for a wide range of pathological conditions since this hormone may prove to be therapeutically and clinically beneficial. In addition, a new hormone, betatrophin, has recently been identified by Yi and coworkers. Both hormones are connected by a new pathway clearly involved in insulin resistance. We hypothesize here how these hormones may be linked and their possible implications in both aged-reduced restricted regenerative capacity and dedifferentiated β cells of diabetic patients.
Biomechanical comparison of 3 ankle braces with and without free rotation in the sagittal plane.

CONTEXT Various designs of braces including hinged and nonhinged models are used to provide external support of the ankle. Hinged ankle braces supposedly allow almost free dorsiflexion and plantar flexion of the foot in the sagittal plane. It is unclear, however, whether this additional degree of freedom affects the stabilizing effect of the brace in the other planes of motion. OBJECTIVE To investigate the dynamic and passive stabilizing effects of 3 ankle braces, 2 hinged models that provide free plantar flexion-dorsiflexion in the sagittal plane and 1 ankle brace without a hinge. DESIGN Crossover study. SETTING University Movement Analysis Laboratory. PATIENTS OR OTHER PARTICIPANTS Seventeen healthy volunteers (5 women, 12 men; age = 25.4 ± 4.8 years; height = 180.3 ± 6.5 cm; body mass = 75.5 ± 10.4 kg). INTERVENTION(S) We dynamically induced foot inversion on a tilting platform and passively induced foot movements in 6 directions via a custom-built apparatus in 3 brace conditions and a control condition (no brace). MAIN OUTCOME MEASURE(S) Maximum inversion was determined dynamically using an in-shoe electrogoniometer. Passively induced maximal joint angles were measured using a torque and angle sensor. We analyzed differences among the 4 ankle-brace conditions (3 braces, 1 control) for each of the dependent variables with Friedman and post hoc tests (P < .05). RESULTS Each ankle brace restricted dynamic foot-inversion movements on the tilting platform as compared with the control condition, whereas only the 2 hinged ankle braces differed from each other, with greater movement restriction caused by the Ankle X model. Passive foot inversion was reduced with all ankle braces. Passive plantar flexion was greater in the hinged models as compared with the nonhinged brace. CONCLUSIONS All ankle braces showed stabilizing effects against dynamic and passive foot inversion. Differences between the hinged braces and the nonhinged brace did not appear to be clinically relevant.
STRUCTURAL, NON- STRUCTURAL AND INFORMAL COORDINATION MECHANISMS. PROPOSAL AND VALIDATION OF MEASUREMENT SCALES

The objective of this study is to design and validate scales for measuring several structural, non-structural and informal coordination mechanisms. The first group is primarily linked to managerial posts or specific bodies. This study focuses on the design of networks, project and development teams, and work teams. Non-structural coordination mechanisms do not characteristically create bodies or jobs, but complement them. For this group we design and validate other scales for measuring the regulation of work processes, skills and outcomes. Lastly, scales for mechanisms of an informal nature are provided for aspects such as the strive for socialization and mutual adaptation. After creating a group of 43 items, the reliability and validity (convergent and discriminant validity) of the items were verified. A sample of 167 large Spanish firms was used for the analysis. KEYWORDS: Measurement scales, Reliability, Validity, Coordination mechanisms.
Urban Development and the Politics of a Creative Class: Evidence from a Study of Artists

In this paper I critique the notion of ‘the creative class' and the fuzzy causal logic about its relationship to urban growth. I argue that in the creative class, occupations that exhibit distinctive spatial and political proclivities are bunched together, purely on the basis of educational attainment, and with little demonstrable relationship to creativity. I use a case study of artists, one element of the purported creative class, to probe this phenomenon, demonstrating that the formation, location, urban impact, and politics of this occupation are much more complex and distinctive than has been suggested previously. The spatial distribution of artists is a function of semiautonomous personal migration decisions, local nurturing of artists in dedicated spaces and organizations, and the locus of artist-employing firms. Artists have very high rates of self-employment, boosting regional growth by providing import-substituting consumption activities for residents and through direct export of their work. Their contribution to attracting high-tech activity is ambiguous—causality may work in the opposite direction. Artists play multiple roles in an urban economy—some progressive, some problematic. I argue that artists as a group make important, positive contributions to the diversity and vitality of cities, and their agendas cannot be conflated with neoliberal urban political regimes. I show the potential for artists as a political force to lead in social and urban transformation and the implausibility of their common cause with other members of Florida's ‘creative class’, such as scientists, engineers, managers, and lawyers.
Competitive Inhibition of the Capsaicin Receptor-Mediated Current by Dehydroepiandrosterone in Rat Dorsal Root Ganglion Neurons

The effects of dehydroepiandrosterone (5-androsten-3β-ol-17-one; DHEA) and related steroids on the capsaicin receptor-mediated current were studied in acutely dissociated rat dorsal root ganglion neurons using the whole-cell voltage-clamp technique. DHEA rapidly and reversibly inhibited the capsaicin-induced current in a concentration-dependent manner, with an EC50 of 6.7 μM and a maximal inhibition of 100%. DHEA increased the capsaicin EC50 with little effect on the capsaicin maximal response, suggesting that the blocking action of DHEA is competitive. Neither the capsaicin response nor inhibition of the capsaicin response by extracellularly applied DHEA was significantly affected by inclusion of a saturating concentration of DHEA in the electrode buffer, arguing that DHEA acted at the extracellular surface of the membrane. Moreover, DHEA did not act through protein phosphatases to inhibit the capsaicin-induced current. Furthermore, the stereoisomer of DHEA, 5-androsten-3α-ol-17-one, failed to inhibit the capsaicin-induced current, producing instead a potentiating effect on the capsaicin response, demonstrating that the interaction of steroids with the capsaicin receptor is stereospecific. The inhibitory action of DHEA on the capsaicin-induced current may provide a basis for reducing capsaicin receptor-mediated nociception.
Occurrence of Ochratoxin A in the Wild Boar (Sus scrofa): Chemical and Histological Analysis

Ochratoxins are fungal secondary metabolites that may contaminate a broad variety of foodstuffs, such as grains, vegetables, coffee, dried fruits, beer, wine and meats. Ochratoxins are nephrotoxins, carcinogens, teratogens and immunotoxins in rats and are also likely to be in humans. In 2009/2010, a survey of the presence of Ochratoxin A (OTA) in regularly hunted wild boars in the Calabria region of southern Italy detected OTA in 23 animals in the kidney, urinary bladder, liver and muscles: 1.1 ± 1.15, 0.6 ± 0.58, 0.5 ± 0.54 and 0.3 ± 0.26 μg/kg, respectively. Twelve tissue samples showed levels of OTA higher than the guideline level (1 μg/kg) established by the Italian Ministry of Health. In five wild boars, gross-microscopic lesions were described for the organs displaying the highest concentrations of OTA determined by HPLC-FLD analysis, i.e., the kidney, liver and urinary bladder.
Apocynin Attenuates Lipopolysaccharide-Induced Lung Injury in an Isolated and Perfused Rat Lung Model

ABSTRACT Apocynin (Apo) suppresses the generation of reactive oxygen species that are implicated in lipopolysaccharide (LPS)–induced lung injury (LPSLI). We thus hypothesized that Apo may attenuate LPSLI. In addition, we explored the cellular and molecular mechanisms of Apo treatment in LPSLI. Lipopolysaccharide-induced lung injury was induced by intratracheal instillation of 10 mg/kg LPS in isolated and perfused rat lung model. Apocynin was administered in the perfusate at 15 min before LPS was administered. Hemodynamics, lung injury indices, inflammatory responses, and activation of apoptotic pathways were assessed. There was an increase in lung vascular permeability associated with lung weight gain after LPS exposure. The levels of interleukin 1&bgr; (IL-1&bgr;), tumor necrosis factor &agr; (TNF-&agr;), macrophage inflammatory protein 2, H2O2, and albumin increased in the bronchoalveolar lavage fluid. Adhesion molecule of neutrophil (CD31) was upregulated. The expression of TNF-&agr;, IL-1&bgr;, glutathione, myeloperoxidase, JNK, P38, caspase 3, p-AKT, and plasminogen activator inhibitor 1 in lung tissue was greater in the LPS groups when compared with the control group. Upregulation and activation of nuclear factor &kgr;B occurred along with increased histopathologic lung injury score in LPSLI. The Apo attenuated these inflammatory responses including the levels of CD31, H2O2, TNF-&agr;, IL-1&bgr;, myeloperoxidase, P38, and nuclear factor &kgr;B along with downregulation of apoptosis as reflected by caspase 3 and p-AKT. In addition, Apo attenuated the increase in lung weight, bronchoalveolar lavage fluid albumin content, and the histopathologic lung injury score. In conclusion, LPSLI is associated with increased inflammatory responses, apoptosis, and coagulation. The administration of Apo attenuates LPSLI through downregulation of the inflammatory responses and apoptosis.
PRISENIT -- A Probabilistic Search Recommendation Algorithm to Improve Search Efficiency for Network Intelligence and Troubleshooting

When searching for data in a telecommunications network management application, large search result sets are common. In order to refine the results to retrieve useful information existing systems normally require additional user intervention such as appending or removing a search keyword, adding a filter, grouping results, etc. This work proposes a Probabilistic Search Recommendation Algorithm to Improve Search Efficiency for Network Intelligence and Troubleshooting (PRISENIT). PRISENIT is a query-based recommendation algorithm intended to improve search efficiency and usability for telecommunication system management. PRISENIT is an extension of an item-based collaborative filtering algorithm. It uses correlation-based similarity and users' implicit feedback in order to improve search efficiency. It learns from previous experiences in order to optimize decision-making. Currently there exists no known query-based recommender adaptation mechanism for network management. Existing search engines use previous user searches to make a suggestion based on the keyword. PRISENIT not only considers search terms, it also considers the influence of filters and features in order to makes network searches more efficient as it removes the necessity for users to manually choose search features or search filters. Experimental results show that PRISENIT can improve user experience in a telecommunications management environment.
Location and Time Based Clone Detection in Wireless Sensor Networks

A Wireless Sensor Network (WSN) consists of several sensor nodes that are deployed in a aggressive environment to monitor and record the changes that take place in certain parameters of the environment. Sensor nodes that can communicate with each other over a wireless channel can be captured and compromised by an adversary. After such a compromise an adversary can replicate a few sensor nodes, and insert arbitrary number of replicas in the network field to undermine the operation of the network. Several clone detection protocols have been proposed in the literature as a framework to maximize the lifetime and security of the wireless sensor network. These are based on device types, deployment strategies, detection methodologies and detection ranges and try to mitigate the threat against wireless sensor networks. The Location Claim Approach is an effective clone detection protocol based on grid deployment. It can detect the clone nodes by sending each node's location claim (location and ID) to other nodes in a predetermined zone. However there are certain limitations in the current study. The unnecessary forwarding of location claim between the sensor nodes will increase the claim storage, communication and computation overhead. Hence in the proposed study the methodology is developed to overcome these problems by making the deployment location more accurate. This is achieved by assigning the time interval for all sensor nodes. Hence in this proposed work, an erroneously deployed node which is marked as untrusted node finishes the neighbor discovery before the time interval. Therefore it can be remarked as trusted node. Finally the total energy consumed by the proposed method consumes less energy.
Relationship of gestation protein and feed intake level over a five-parity period using a high-producing sow genotype.

High-producing Landrace-Large White crossbred gilts (n = 50) involving 198 farrowings were used to evaluate dietary gestation protein (13 vs 16% CP) and gestation feed intakes (Control vs High), and their interaction, over a five-parity period on sow reproductive performance. Gestation feed intake for Control was 1.81 kg/d during parity 1, increasing by . 09 kg for each successive parity. The daily feed intake for High was greater by . 13 kg or approximately 450 kcal ME at each respective parity. The experiment was a 2 x 2 in a randomized complete block design conducted in two replicates with parity nested within sow groups. Sow weights and backfat thickness were determined at various intervals. A lactation diet containing . 90% lysine in parity 1 and . 80% lysine during parities 2 to 5 was fed to all sows from farrowing to weaning (21 d). Sow and pig weights, feed intakes, and colostrum and 21-d milk samples were collected during each lactation. The High feed intake and the 13% protein diet resulted in greater (P < .01) backfat thicknesses, and the effects were additive. Backfat thickness declined quadratically (P < .01) by parity and from late gestation to the rebreeding period of the following parity. The High feed intake resulted in a larger litter size (P < .01), whereas dietary gestation protein concentration had no effect on parturition performance. Sows in each parity consumed more (P < .01) feed from 0 to 7 d postpartum and for the overall 21-d lactation period (P < .01) for parity 1 when the 16% gestation protein had been fed. Gestation feed intake regimens did not affect lactation feed intake. Neither gestation variable affected colostrum or 21-d milk fat, but concentrations declined (P < .01) in all groups after parity 2. Parity 1 litters were heavier at 14 and 21 d, with larger litter gains from 0 to 14 and 0 to 21 d when gestating sows had been fed the 16% protein and the High feed intake combination compared to the other sow treatment groups. From parity 2 to 5, litter weights and gains were similar for all treatment groups. This resulted in a three-way interaction response (P < .05) for these variables. These results suggest that primiparous sows required a greater gestation protein concentration and greater feed intake than generally recommended, but the 13% CP diet at the High feed intake was effective in older sows.