Miracle-dz/UniFAR-FTUs huggingface dataset:
New Exams for New Professional Styles

Recruiting professionals for schools’ media resources centres needs to take into account the new dimensions of the information society. This article describes the radical reform of the very high‐stakes and competitive national selection of those professionals in France. The new exam is now driven by a problem‐solving approach and based on an extensive use of electronic resources. This has raised very serious issues in terms of fairness, reliability and security. This article describes how those issues have been addressed. De nouveaux examens pour de nouveaux styles professionels. Recruter les personnels en charge des centres de documentation des établissements scolaires exige de prendre en compte les nouvelles dimensions de la Société de l’Information. Cet article décrit la transformation radicale de ce difficile concours de recrutement en France. Les nouvelles épreuves sont désormais conçues selon une approche de résolution de problèmes et fondées sur l’utilisation systématique des ressources électroniques. Ce qui a soulevé de délicats problèmes d’équité, de fiabilité et de sécurité. Cet article explique comment ils ont été résolus. Neue Prüfungen für neue Berufsanforderungen. Mitarbeiter für die Medien Ressource Zentren der Schulen einzustellen, erfordert, die neuen Dimensionen der Informationsgesellschaft mit in Betracht zu ziehen. Dieser Artikel beschreibt die radikale Reform der mit hohem Einsatz und konkurrenzbetont ablaufenden nationalen Auswahl dieser Berufstätigen in Frankreich. Die neue Prüfung basiert jetzt auf einem Problemlöse‐ Ansatz und wird von umfassender Verwendung elektronischer Ressourcen bestimmt. Damit ergaben sich sehr ernste Fragen in Bezug auf Gerechtigkeit, Zuverlässigkeit und Sicherheit. Dieser Beitrag beschreibt, wie diese Problemstellungen angesprochen worden sind.
Metabolite concentrations in the developing brain estimated with proton MR spectroscopy

The purpose of the present study was to estimate absolute concentrations and relaxation time constants of metabolites that were detectable with proton magnetic resonance (MR) spectroscopy in the healthy preterm, term, and infant brain. Five MR spectra were recorded for each infant by using STEAM (stimulated‐echo acquisition mode) sequences with different TEs and TRs. Water was used as an internal standard. The T1 of choline‐containing compounds (Cho) and the T1 of phosphocreatine plus creatine (PCr+Cr) decreased. The T2 of the N‐acetyl‐L‐aspartate (NAA) resonance increased, probably because of a relatively larger signal overlap with glutamate in the most immature brains. The concentration of NAA almost doubled, whereas the Cho concentration showed only a nonsignificant tendency to decrease; therefore, the well‐known increase in the ratio of NAA to Cho appears to be due mostly to an increase in NAA concentration. The concentration of PCr+Cr increased rapidly and reached adolescent values at approximately 4 months of age.
Effects of general anaesthetics on cultured Lymnaea neurones.

In order to elucidate the mode of action of general anaesthetics we are using neurones of Lymnaea stagnalis as a model system. Neurones exhibit mainly two types of responses to anaesthetics delivered at clinical concentrations, i.e., either gradually going into quiescence or exhibiting paroxysmal depolarizing shifts (PDS). In order to determine whether these differences are due to intrinsic membrane properties or because of synaptic effects, cultured neurones are being used so that cells can be studied in isolation from any synaptic effects. Cells in culture retain their basic electrophysiological characteristics and behave in a similar manner to the applied anaesthetics as do whole brain preparations. Demonstration of PDS and quiescence in cultured neurones shows that these phenomena are due to membrane effects and not due to synaptic inputs. The effects of anaesthetics observed seem to be consistent with the suggestion that anaesthetics may influence the inward calcium current or other calcium-dependent currents.
Alveolar bone graft evaluation agreement using cone beam computed tomography in cleft lip and palate patients: a pilot study.

OBJECTIVE To develop and test assessor agreement using a new cone beam computed tomography (CBCT) examination method for evaluating the outcome of alveolar bone grafts in cleft lip and palate patients. MATERIAL AND METHOD Twenty patients with complete cleft lip and cleft palate who had undergone alveolar bone grafting with CBCT follow-up 3-6 months postoperative at the Faculty of Dentistry, Khon Kaen University were recruited into the study. Four trained clinical assessors (two orthodontists, an oral surgeon and an oral radiologist) had made a judgment of three outcome measurements: 1) cemento-enamel junction (CEJ) to marginal bone level of the teeth adjacent to the cleft site, 2) marginal bone level to root apex of the teeth adjacent to the cleft site, 3) labio-lingual alveolar bone grafted thickness. Repeat measurements were made by the same assessors. RESULTS The Kappa values of intra-assessor agreements of each assessor were 0.82, 0.91, 0.91 and 1, respectively, while the inter-assessor agreements for the first and second time of determinations were 0.81 and 0.74. CONCLUSION This CBCT method for scoring alveolar bone graft outcomes produced good agreement among four assessors, which suggests its potential use to evaluate the success of alveolar bone grafting. In the future, this new method of alveolar bone graft evaluation should be compared with the standard method for testing validity.
Reduced Susceptibility of Staphylococcus aureus to Vancomycin and Platelet Microbicidal Protein Correlates with Defective Autolysis and Loss of Accessory Gene Regulator (agr) Function

ABSTRACT Loss of agr function, vancomycin exposure, and abnormal autolysis have been linked with both development of the GISA phenotype and low-level resistance in vitro to thrombin-induced platelet microbicidal proteins (tPMPs). We examined the potential in vitro interrelationships among these parameters in well-characterized, isogenic laboratory-derived and clinical Staphylococcus aureus isolates. The laboratory-derived S. aureus strains included RN6607 (agrII-positive parent) and RN6607V (vancomycin-passaged variant; hetero-GISA), RN9120 (RN6607 agr::tetM; agr II knockout parent), RN9120V (vancomycin-passaged variant), and RN9120-GISA (vancomycin passaged, GISA). Two serial isolates from a vancomycin-treated patient with recalcitrant, methicillin-resistant S. aureus (MRSA) endocarditis were also studied: A5937 (agrII-positive initial isolate) and A5940 (agrII-defective/hetero-GISA isolate obtained after prolonged vancomycin administration). In vitro tPMP susceptibility phenotypes were assessed after exposure of strains to either 1 or 2 μg/ml. Triton X-100- and vancomycin-induced lysis profiles were determined spectrophotometrically. For agrII-intact strain RN6607, vancomycin exposure in vitro was associated with modest increases in vancomycin MICs and reduced killing by tPMP, but no change in lysis profiles. In contrast, vancomycin exposure of agrII-negative RN9120 yielded a hetero-GISA phenotype and was associated with defects in lysis and reduced in vitro killing by tPMP. In the clinical isolates, loss of agrII function during prolonged vancomycin therapy was accompanied by emergence of the hetero-GISA phenotype and reduced tPMP killing, with no significant change in lysis profiles. An association was identified between loss of agrII function and the emergence of hetero-GISA phenotype during either in vitro or in vivo vancomycin exposure. In vitro, these events were associated with defective lysis and reduced susceptibility to tPMP. The precise mechanism(s) underlying these findings is the subject of current investigations.
Salmonella Hepatitis: An Uncommon Complication of a Common Disease

Typhoid fever is a very common infectious disease of tropics, associated with high morbidity and mortality. Typhoid fever is often associated with hepatomegaly and mildly deranged liver functions; a clinical picture of acute hepatitis is a rare complication. We report a young patient who presented with fever and jaundice and was found to have acute hepatitis secondary to typhoid fever. Recognition of Salmonella hepatitis is of clinical importance as it can mimic acute viral hepatitis. Early institution of specific therapy can improve the prognosis in these patients. Typhoid fever is a very common infectious disease of tropics, associated with high morbidity and mortality. Typhoid fever is often associated with hepatomegaly and mildly deranged liver functions; a clinical picture of acute hepatitis is a rare complication. We report a young patient who presented with fever and jaundice and was found to have acute hepatitis secondary to typhoid fever. Recognition of Salmonella hepatitis is of clinical importance as it can mimic acute viral hepatitis. Early institution of specific therapy can improve the prognosis in these patients.
Different Effects of Mibefradil and Amlodipine on Coronary Vessels and During &bgr;-Adrenergic Stimulation in Conscious Dogs

Coronary effects of Ca2+-channel blockers mibefradil and amlodipine were compared in conscious dogs. Ten dogs were instrumented for measurement of aortic and left ventricular pressures, circumflex coronary blood flow velocity (CBFv), and coronary diameter (CD). A permanent catheter was implanted in the circumflex coronary artery. At doses having no systemic effects (7.5–150 &mgr;g/kg), mibefradil and amlodipine increased CBFv and CD dose dependently. At the same dose, mibefradil increased less CBFv than amlodipine. However, for a similar increase in CBFv induced by amlodipine, mibefradil increased CD more. BAY K8644, an L-type Ca2+-channel agonist, prevented the CBFv and CD responses to amlodipine, but minimally affected the coronary responses to mibefradil. Intracoronary isoproterenol (6 ng/kg) increased LV dP/dt max, CBFv, and CD. Amlodipine markedly altered these responses, while mibefradil did not affect LV inotropic response and slightly altered CBFv response to isoproterenol. Thus, in conscious dogs, both mibefradil and amlodipine exert coronary vasodilation, with different patterns on coronary conductance and resistance vessels and during &bgr;-adrenergic stimulation. These differences could be related to their actions on different Ca2+ channels.
Searching for modified growth patterns with tomographic surveys

In alternative theories of gravity, designed to produce cosmic acceleration at the current epoch, the growth of large scale structure can be modified. We study the potential of upcoming and future tomographic surveys such as Dark Energy Survey (DES) and Large Synoptic Survey Telescope (LSST), with the aid of cosmic microwave background (CMB) and supernovae data, to detect departures from the growth of cosmic structure expected within general relativity. We employ parametric forms to quantify the potential time- and scale-dependent variation of the effective gravitational constant and the differences between the two Newtonian potentials. We then apply the Fisher matrix technique to forecast the errors on the modified growth parameters from galaxy clustering, weak lensing, CMB, and their cross correlations across multiple photometric redshift bins. We find that even with conservative assumptions about the data, DES will produce nontrivial constraints on modified growth and that LSST will do significantly better.
Stabilized finite element method for Navier-Stokes equations with physical boundary conditions

This paper deals with the numerical approximation of the 2D and 3D Navier-Stokes equations, satisfying nonstandard boundary conditions. This lays on the finite element discretisation of the corresponding Stokes problem, which is achieved through a three-fields stabilized mixed formulation. A priori and a posteriori error bounds are established for the nonlinear problem, ascertaining the convergence of the method. Finally, numerical tests are presented, including mesh refinement via error indicators.
Recovery from rhinocerebral mucormycosis in a ketoacidotic diabetic patient: a case report

An 18-year-old woman with insulin-dependent diabetes mellitus developed an infection of the paranasal sinuses with Rhizopus oryzae resulting in facial swelling, hemiplegia and blindness of the right eye. The therapy of this rhinocerebral mucormycosis consisted of extensive surgical debridement, administration of high-dose amphotericin B, hyperbaric oxygen and control of the underlying predisposing diabetes mellitus. The patient eventually recovered with however, the loss of one eye.
The Effects of Schooling on Gender Differences

The study on which this article is based examined the gender differences in educational achievements based on a longitudinal sample of more than 45,000 secondary school students in Hong Kong who took a public examination in 1997. The results coincided with the findings from recent British studies that boys did less well than girls in all areas of the school curriculum. The multilevel analyses of the effects of schooling, after controlling for initial ability, indicated that schooling did have an effect on gender differences. Girls achieved better results studying in single-sex schools whereas boys achieved better in co-educational schools. Compared with other students, it was those boys studying in the arts stream that did the least well in the public examination. The results are discussed in the context of the methodology of investigating gender differences and of the substantive questions of school effectiveness.
PERFORMANCE IN COLLEGE-LEVEL COURSES AMONG STUDENTS CONCURRENTLY ENROLLED IN REMEDIAL COURSES: POLICY IMPLICATIONS

Community colleges utilize open-door admission policies to provide educational opportunities for all students, including those who are academically under-prepared in one or more areas. Current approaches to assisting under-prepared students include the targeted delivery of remedial courses in math, English, and reading. This approach typically relies on the use of standardized placement tests to determine whether students have remedial needs. Based on those placement test scores, students may have a remedial need in only one of the core academic areas (e.g., math, English, or reading). In such cases, students may concurrently enroll in required remedial courses and college-level courses unrelated to the area in which they are considered to be academically under-prepared. The research reported in this article evaluated the assumption that a student's under-preparedness is limited to a specific area by assessing the college-level performance of students concurrently enrolled in remedial and college-level courses. The results show that college-level pass rates are much lower among students concurrently enrolled in remedial courses who do not successfully complete one or more of these remedial courses. These students under-perform irrespective of the type of college-level course. In contrast, students who pass their remedial courses are generally successful in their college-level courses. Policy implications in regard to developmental education are discussed.
Clinical impact of increasing left ventricular pacing output in cardiac resynchronization therapy – the new optimization strategy

We report a patient who did not improve after standard optimization of atrioventricular and intraventricular pacing timing, but showed response to cardiac resynchronization therapy (CRT) after increasing left ventricular (LV) pacing output. Increasing LV pacing output is one of the useful optimization methods for CRT nonresponder.
Graphene Frequency Multipliers

In this letter, the ambipolar transport properties of graphene flakes have been used to fabricate full-wave signal rectifiers and frequency-doubling devices. By correctly biasing an ambipolar graphene field-effect transistor in common-source configuration, a sinusoidal voltage applied to the transistor gate is rectified at the drain electrode. Using this concept, frequency multiplication of a 10-kHz input signal has been experimentally demonstrated. The spectral purity of the 20-kHz output signal is excellent, with more than 90% of the radio-frequency power in the 20-kHz frequency. This high efficiency, combined with the high electron mobility of graphene, makes graphene-based frequency multipliers a very promising option for signal generation at ultrahigh frequencies.
Towards the cross-domain interoperability of IoT platforms

The Internet of Things is evolving around a plethora of vertical platforms, each specifically suited to a given scenario and often adopting proprietary communications, device and resource control protocols. The emerging need for cross-domain IoT applications and services highlights the necessity of interoperability across IoT platforms for a unified and secure sharing of and access to sensing/actuating resources. This position paper describes the current state of the IoT landscape, the opportunities that appear towards its sustainable evolution as well as the challenges that need to be addressed. In this context, the vision and objectives of the H2020 symbIoTe project are also presented; symbIoTe aims at the interoperability of IoT platforms by offering a flexible interoperability framework that will allow i) vertical IoT platforms to cooperate, ii) collaborative IoT platforms to form IoT-platform federations for exchange of resources and iii) independent developers to create innovative and cross-domain applications.
Field Research in Management Accounting and Control: A Review and Evaluation

Surveys the field research literature in management accounting and control (MAC) published in the period 1984‐1992. Proposes a definition of field research and compares the 82 published works that meet this definition with respect to their motivations, research designs and presentation formats. The comparison reveals the tremendous diversity among the field research publications. Evaluates the methods and contributions of this research ‐ field researchers usually choose interesting, relevant topics but many of the works have weaknesses in research design, data presentation and interpretation of findings. Concludes with some observations on the costs, risks, and potential payoffs of field research.
Mesangial sclerotic change with persistent proteinuria in rats after two consecutive injections of monoclonal antibody 1–22–3

Irreversible mesangial changes with persistenl proteinuria were induced in rats given two consecutive injections 2 weeks apart of a MoAb 1–22–3 to rat mesangial cell. The characteristics of the resulting lesions were investigated and compared with those of the reversible change induced by a single injection. At 24 h after the second injection, mesangiolytic changes similar to those after a single injection were evident. The accumulation of macrophagc‐like cells in glomeruli observed at I week after the first injection was not evident during the experimental period after the second injection. Hypercellularity with the characteristics of intrinsic mesangial cell and increased mesangial matrix were already present I week after the second injection. And mesangial sclerotic change progressed up to 6 months. Deposition of collagen type I and type III and accumulation of collagen fibril at the ullraslructural level were evident in rats 6 months after the second injection. Proteinuria started immediately and continued for more than 6 months after the second injection. The mesangial sclerotic change with persistent proteinuria described here is considered to be a better model for investigating the mechanism of chronic progression of human mesangial proliferative glomerulo‐nephritis.
Inhibition of glycogen synthase kinase 3 beta ameliorates liver ischemia reperfusion injury by way of an interleukin‐10‐mediated immune regulatory mechanism

The ubiquitous serine/threonine kinase glycogen synthase kinase 3 beta (Gsk3β) differentially regulates macrophage Toll‐like receptor (TLR)‐triggered pro‐ and anti‐inflammatory cytokine programs. This study was designed to determine the in vivo role and therapeutic potential of Gsk3β modulation in tissue inflammation and injury in a murine model of liver partial warm ischemia/reperfusion injury (IRI). As a constitutively activated liver kinase, Gsk3β became quickly inactivated (phosphorylated) following IR. The active Gsk3β, however, was essential for the development of IRI pathology, as administration of its specific inhibitor, SB216763, ameliorated the hepatocellular damage, evidenced by reduced serum alanine aminotransferase (sALT) levels and well‐preserved liver architecture compared with controls. The liver protective effect of Gsk3β inhibition was dependent on an immune regulatory mechanism, rather than direct cytoprotection via mitochondria permeability transition pores (MPTP). Indeed: (1) coadministration of SB216763 and atractyloside (MPTP opener) failed to abrogate a local cytoprotective Gsk3β inhibition effect; (2) SB216763 selectively inhibited IR‐triggered liver pro‐inflammatory, but spared interleukin (IL)‐10, gene induction programs; and (3) IL‐10 neutralization restored liver inflammation and IRI in SB216763‐treated mice. Gsk3β inactivation by IR was a self‐regulatory mechanism in liver homeostasis, critically dependent on phosphoinositide 3 (PI3)‐kinase activation, as administration of a PI3 kinase inhibitor, wortmannin, reduced Gsk3 phosphorylation and augmented liver damage. In vitro, IL‐10 was critical for the suppression of pro‐inflammatory gene programs by Gsk3 inhibition in bone marrow‐derived macrophages in response to TLR4 stimulation. Conclusion: Our novel findings document the key immune regulatory function of Gsk3β signaling in the pathophysiology of liver IRI, and provide a rationale to target Gsk3β as a refined therapeutic strategy to ameliorate liver IRI. (HEPATOLOGY 2011;)
Initial experience with endoscopic ultrasound-guided fine needle aspiration of renal masses: indications, applications and limitations.

CONTEXT Tissue sampling of renal masses is traditionally performed via the percutaneous approach or laparoscopicaly. The utility of endoscopic ultrasound to biopsy renal lesions it remains unclear and few cases have been reported. OBJECTIVES To evaluate the feasibility and outcome of endoscopic ultrasound fine needle aspiration of renal tumors. METHODS Consecutive subjects undergoing attempted endoscopic ultrasound fine needle aspiration of a kidney mass after evaluation with computerized tomography or magnetic resonance. RESULTS Ten procedures were performed in nine male patients (median age 54.7 years) on the right (n = 4) and left kidney (n = 4) and bilaterally (n = 1). Kidney masses (median diameter 55 mm ; range 13-160 mm) were located in the upper pole (n = 3), the lower pole (n = 2) and the mesorenal region (n = 3). In two cases, the mass involved more than one kidney region. Surgical resection confirmed renal cell carcinoma in six patients in whom pre-operative endoscopic ultrasound fine needle aspiration demonstrated renal cell carcinoma. No complications were reported. CONCLUSIONS Endoscopic ultrasound fine needle aspiration appears as a safe and feasible procedure with good results and minimal morbidity.