Miracle-dz/UniFAR-FTUs huggingface dataset:
Measuring the relevance of different-typed objects in weighted signed heterogeneous information networks

Relevance measure in both homogeneous and heterogeneous networks has been extensively studied. However, how to measure the relevance among different-typed objects in weighted signed heterogeneous information networks remains an open problem. It is challenging to incorporate both positive and negative multi-typed relationships simultaneously in signed heterogeneous networks due to the opposite opinions implied by them. To this end, this paper proposes a random walk based approach for relevance measure by utilizing and modeling the rich semantic information in weighted signed heterogeneous networks. Particularly, we first transform a signed network into a non-signed network according to the different semantic meanings represented by positive and negative relationships. This paves the way to properly utilize negative relationships. Next, we conduct random walk from the source object to the target object based on a bunch of single meta-paths separately. Finally, we combine multiple meta-paths together to obtain a more comprehensive relatedness between the source object and the target object. Extensive experiments on real datasets demonstrate the superior performance of the proposed approach.
Visualized Data Processing Technology under Cloud Computing

This paper puts forward visualized data arrangement strategy of self-adaptation cloud computing, dynamically arranges virtual machine to physical host with less resources, so that it closes idle host, perceives optimal regression algorithm by combining with maximum relevant strategy and energy, so that it realizes dynamic balance of host load and increases efficiency as well as realizes service hand-over with higher reliability by load prediction of host resources, which avoids excessive SLA violation between user and resources suppliers. The test result indicates that reducing energy consumption and times of SLA violation can effectively enhance the overall resources utilization rate of cloud computing center.
Seropositivity for HIV and the development of AIDS or AIDS related condition: three year follow up of the San Francisco General Hospital cohort

The three year actuarial progression rate to the acquired immune deficiency syndrome (AIDS) in a cohort of men in San Francisco who were seropositive for the human immuno-deficiency virus (HIV) was 22%. An additional 26 (19%) developed AIDS related conditions. β2 Microglobulin concentration, packed cell volume, HIV p24 antigenaemia, and the proportion and number of T4 lymphocytes each independently predicted progression to AIDS. β2 Microglobulin was the most powerful predictor. The 111 subjects tested who were normal by all predictors (40%) had a three year progression rate of 7%, and the 68 subjects who were abnormal by two or more predictors (24%) had a progression rate of 57%. Two thirds of all men who progressed to AIDS were in the last group. The median T4 lymphocyte count in subjects who did not progress to AIDS fell from 626 × 106 to 327 × 106/1. HIV p24 antigenaemia developed in 7% of the subjects per year. The proportion who were abnormal by two or more predictive variables rose to 41%. At three years an estimated two thirds of the seropositive subjects showed clinical AIDS, an AIDS related condition, or laboratory results that were highly predictive of AIDS. It is concluded from the observed rates and the distribution of predictive variables at three years that half of the men who were seropositive for HIV will develop AIDS by six years after the start of the study, and three quarters will develop AIDS or an AIDS related condition.
Circadian misalignment, reward-related brain function, and adolescent alcohol involvement.

BACKGROUND Developmental changes in sleep and circadian rhythms that occur during adolescence may contribute to reward-related brain dysfunction, and consequently increase the risk of alcohol use disorders (AUDs). METHODS This review (i) describes marked changes in circadian rhythms, reward-related behavior and brain function, and alcohol involvement that occur during adolescence, (ii) offers evidence that these parallel developmental changes are associated, and (iii) posits a conceptual model by which misalignment between sleep-wake timing and endogenous circadian timing may increase the risk of adolescent AUDs by altering reward-related brain function. RESULTS The timing of sleep shifts later throughout adolescence, in part due to developmental changes in endogenous circadian rhythms, which tend to become more delayed. This tendency for delayed sleep and circadian rhythms is at odds with early school start times during secondary education, leading to misalignment between many adolescents' sleep-wake schedules and their internal circadian timing. Circadian misalignment is associated with increased alcohol use and other risk-taking behaviors, as well as sleep loss and sleep disturbance. Growing evidence indicates that circadian rhythms modulate the reward system, suggesting that circadian misalignment may impact adolescent alcohol involvement by altering reward-related brain function. Neurocognitive function is also subject to sleep and circadian influence, and thus circadian misalignment may also impair inhibitory control and other cognitive processes relevant to alcohol use. Specifically, circadian misalignment may further exacerbate the cortical-subcortical imbalance within the reward circuit, an imbalance thought to explain increased risk-taking and sensation-seeking during adolescence. Adolescent alcohol use is highly contextualized, however, and thus studies testing this model will also need to consider factors that may influence both circadian misalignment and alcohol use. CONCLUSIONS This review highlights growing evidence supporting a path by which circadian misalignment may disrupt reward mechanisms, which may in turn accelerate the transition from alcohol use to AUDs in vulnerable adolescents.
Wolbachia-Mediated Cytoplasmic Incompatibility Is Associated with Impaired Histone Deposition in the Male Pronucleus

Wolbachia is a bacteria endosymbiont that rapidly infects insect populations through a mechanism known as cytoplasmic incompatibility (CI). In CI, crosses between Wolbachia-infected males and uninfected females produce severe cell cycle defects in the male pronucleus resulting in early embryonic lethality. In contrast, viable progeny are produced when both parents are infected (the Rescue cross). An important consequence of CI–Rescue is that infected females have a selective advantage over uninfected females facilitating the rapid spread of Wolbachia through insect populations. CI disrupts a number of prophase and metaphase events in the male pronucleus, including Cdk1 activation, chromosome condensation, and segregation. Here, we demonstrate that CI disrupts earlier interphase cell cycle events. Specifically, CI delays the H3.3 and H4 deposition that occurs immediately after protamine removal from the male pronucleus. In addition, we find prolonged retention of the replication factor PCNA in the male pronucleus into metaphase, indicating progression into mitosis with incompletely replicated DNA. We propose that these CI-induced interphase defects in de novo nucleosome assembly and replication are the cause of the observed mitotic condensation and segregation defects. In addition, these interphase chromosome defects likely activate S-phase checkpoints, accounting for the previously described delays in Cdk1 activation. These results have important implications for the mechanism of Rescue and other Wolbachia-induced phenotypes.
Pilot Clinical Trial of Type 1 Dendritic Cells Loaded with Autologous Tumor Lysates Combined with GM-CSF, Pegylated IFN, and Cyclophosphamide for Metastatic Cancer Patients

Twenty-four patients with metastatic cancer received two cycles of four daily immunizations with monocyte-derived dendritic cells (DC). DC were incubated with preheated autologous tumor lysate and subsequently with IFN-α, TNF-α, and polyinosinic:polycytidylic acid to attain type 1 maturation. One DC dose was delivered intranodally, under ultrasound control, and the rest intradermally in the opposite thigh. Cyclophosphamide (day −7), GM-CSF (days 1–4), and pegIFN alpha-2a (days 1 and 8) completed each treatment cycle. Pretreatment with cyclophosphamide decreased regulatory T cells to levels observed in healthy subjects both in terms of percentage and in absolute counts in peripheral blood. Treatment induced sustained elevations of IL-12 in serum that correlated with the output of IL-12p70 from cultured DC from each individual. NK activity in peripheral blood was increased and also correlated with the serum concentration of IL-12p70 in each patient. Circulating endothelial cells decreased in 17 of 18 patients, and circulating tumor cells markedly dropped in 6 of 19 cases. IFN-γ–ELISPOT responses to DC plus tumor lysate were observed in 4 of 11 evaluated cases. Tracing DC migration with [111In] scintigraphy showed that intranodal injections reached deeper lymphatic chains in 61% of patients, whereas with intradermal injections a small fraction of injected DC was almost constantly shown to reach draining inguinal lymph nodes. Five patients experienced disease stabilization, but no objective responses were documented. This combinatorial immunotherapy strategy is safe and feasible, and its immunobiological effects suggest potential activity in patients with minimal residual disease. A randomized trial exploring this hypothesis is currently ongoing.
Tako-tsubo cardiomyopathy

Tako-tsubo cardiomyopathy (transient left ventricular apical ballooning) is a reversible form of cardiomyopathy of unknown etiology. Tako-tsubo Cardiomyopathy (TTC) is typically precipitated by sudden emotional or physical stress, and is associated with excessive sympathetic stimulation and catecholamine release. Its clinical presentation is similar to that of acute coronary syndrome. The diagnosis of TTC must be considered in all patients who develop a transient left ventricular apical (or mid ventricular) ballooning in the absence of obstructive coronary artery disease. Although the prevalence of TTC remains unknown, approximately 2% of all patients presenting with a presumed diagnosis of acute myocardial infarction have been found to have this syndrome. An illustrative case report and literature review is provided.
Advertising and mutual fund asset flows

Purpose – The paper aims to examine the effect of advertising on mutual fund cash flows in the Finnish fund market.Design/methodology/approach – The paper's unique data set allows the observation of the effects of monetary advertising spending and the choice of advertising media.Findings – The paper finds that neither past year's performance nor advertising alone is sufficient to produce increased cash flows. However, advertising together with past performance is found to significantly affect cash flows. The positive effect of advertising is limited to the use of non‐perishable advertising media. Additionally, it is found that fund families spending proportionately more on advertising receive higher asset flows.Originality/value – The data are unique in that they can identify fund families that advertise, and also how much they spent on advertising in a given year and the dollar amount spent on five different media types. Obviously, having also fund level data available would enable more thorough analysis.
ScriptEase: generating scripting code for computer role-playing games

The state-of-the-art in game scripting is to manually script individual game objects that interact in the game. Thousands of non-player characters (NPCs) and props need to be scripted before they play a part in a game adventure. This situation introduces serious concerns about programming effort and reliability. We demonstrate ScriptEase, a tool to facilitate the game scripting process. It is based on generative design patterns for automatic code generation of scripts associated with game objects. ScriptEase is intended for a broad audience, from programmers to game designers and users without programming experience. Game designers can use commonly occurring patterns to generate scripting code without any programming knowledge. This demonstration illustrates the entire process of creating and scripting game props and NPCs.
S1000A12, Chitotriosidase, and Resolvin D1 as Potential Biomarkers of Familial Mediterranean Fever

Familial Mediterranean fever (FMF) is an auto-inflammatory disease characterised by periodic inflammatory attacks. We investigated changes in monocyte-granulocyte derived S10012A and chitotriosidase in both the attack and silent period of FMF for better estimation of inflammation. Endogenous resolvin was determined for utility to restrict inflammation. This study included 29 FMF patients (15 M/14 F) and 30 healthy controls (15 M/15 F). Serum levels of highly sensitive C-reactive protein, serum amiloid A (SAA), S100A12, chitotriosidase, and resolvin D1 were measured. Age, sex, body mass indexes, and lipids were similar between patients and controls. Biomarkers including hs-CRP, SAA, S100A12, chitotriosidase, and resolvin D1 were higher in the attack period of FMF patients compared to controls (P < 0.001). When FMF patients in the silent period were compared with their attack period, hs-CRP, SAA, and chitotriosidase were found elevated in the attack period (P < 0.001, P < 0.001, and P = 0.02 respectively). Serum levels of SAA, S100A12, chitotriosidase, and resolvin D1 in the silent period of FMF patients were still found elevated compared to healthy controls, indicating subclinical inflammation (P < 0.001, P < 0.001, P = 0.009, and P < 0.001 respectively ). In subgroup analysis, patients with M694V homozygote and heterozygote mutations had higher S10012A and hs-CRP compared to other mutation carriers. Our findings indicate that chitotriosidase and S10012A are useful in diagnosis and detection of subclinical inflammation and/or assessment of disease activity in FMF patients. They could be more informative for inflammation in various disease states compared to hsCRP and SAA. Resolvin D1 is elevated in both the attack and silent periods of FMF. It may be helpful to restrict inflammation. Graphical Abstract
Addressing the need for a simpler algorithm for the management of women with urinary incontinence.

AIMS Urinary incontinence (UI) is a prevalent and bothersome condition for many women. However, few women convey the problem to primary care physicians (PCPs), and few PCPs proactively ask about it. One reason may be that available UI recommendations are too complex and difficult to implement. Simplification may encourage greater adaptation as long as a simplified algorithm does not compromise patient safety. I review the opportunity to develop a simpler UI algorithm based on the 3rd edition 2005 International Consultation of Incontinence (ICI) guidelines for the initial management of UI in women. METHODS A literature search for scientific evidence supporting simplification was performed using PubMed, the Cochrane Database, the Agency for Health Care Policy and Research's (AHCPR) 1996 recommendations, and the ICI's 2005 Incontinence Book / CD-ROM. Each level in the ICI algorithm for initial assessment and treatment was evaluated to develop an updated and less complex management strategy. RESULTS A simpler UI algorithm for PCPs should focus on considering reversible risk factors and identifying those who need specialized management. A short questionnaire may be sufficient to assess type and severity of UI, whereas a standard neurologic or comprehensive abdominal and pelvic examination seems unnecessary. Treatment should be restricted to a few evidence-based options. CONCLUSIONS In conclusion, a simpler UI algorithm allows the initiation of evidence-based treatment after a simplified assessment in primary care.
Ameliorative Effects of Soya Bean Oil and Vitamin C on Liver Enzymes in Ethanol-Induced Oxidative Stress in Wistar Rats

The protective potential of soya bean oil and vitamin C on Ethanol-induced oxidative stress in Wistar rats was evaluated. Thirty five Wistar rats of both sexes weighing 120-200g were grouped into five groups of seven rats each. Oxidative stress was induced by administration of 20% ethanol (w/v) for 28 days, at the end of the period of administration, the rats were fasted over night and their blood was collected directly from the heart via cardiac puncture in EDTA sample bottles and the blood was centrifuged and the serum was used to determine the levels of of AST, ALT and ALP in all the groups . The result revealed that Ethanol significantly (p<0.05) increased plasma AST, ALT and ALP levels. Vitamin C significantly (p<0.05) decreased serum AST while soya bean oil produced no significant (p<0.05) effect on plasma AST. The serum levels of ALT and ALP were significantly reduced following vitamin C and Soya bean oil administration. The elevation of serum AST, ALT and ALP after alcohol administration is an indication oxidative stress. The decrease in plasma concentration of the liver enzymes after treatment with vitamin C and Soya bean oil reveals the ameliorative potential of vitamin C and soya bean oil against ethanol-induced oxidative stress in Wistar rats.
Chemical composition, antibacterial and antifungal activities of essential oil from Cordia verbenacea DC leaves

Background: Cordia verbenacea is a Brazilian coastal shrub popularly known as “erva baleeira”. The essential oil from fresh leaves was obtained by hydrodistillation and analyzed by CG/MS. The main components were identified as β-caryophyllene (25.4%), bicyclogermacrene (11.3%), δ-cadinene (9.%) and α-pinene (9.5%). In this study, the antimicrobial activity of Cordia verbenacea was evaluated. Materials and Methods: The minimal inhibitory concentration (MIC) of the essential oil was obtained using the broth microdilution assay (from 512 to 8 μg/ml). Results: The results showed that the essential oil presented fungistatic activity against Candida albicans and Candida krusei and antibacterial activity against Gram-positive strains (Staphylococcus aureus and Bacillus cereus) and against multiresistant Gram-negative (Escherichia coli 27), in all tests the MIC was 64 μg/ml. When the essential oil was associated to aminoglycosides (subinhibitory concentrations, MIC/8), a synergic and antagonic activity was verified. The synergic effect was observed to the amikacin association (MIC reduction from 256 mlto 64 μg/ml) in all strains tested. Conclusion: The essential oil of Cordia verbenacea influences the activity of antibiotics and may be used as an adjuvant in antibiotic therapy against respiratory tract bacterial pathogens.
In vitro anti‐myeloma activity of the Aurora kinase inhibitor VE‐465

This study characterized the preclinical anti‐myeloma activity of VE465, a low molecular weight pan‐Aurora kinase inhibitor. After 96‐h drug exposure, several multiple myeloma (MM) cell lines were more sensitive to VE465 compared to non‐malignant cells. The anti‐MM activity of VE465 was maintained in the presence of interleukin‐6 and, interestingly, enhanced by co‐culture with stromal cells. However, primary MM cells were less responsive than cell lines. Combinations with dexamethasone (Dex), doxorubicin (Doxo) and bortezomib showed no antagonism. Our study highlights the potential role of the tumour microenvironment in modulating the activity of this drug class.
Sport Specialization by Youth Athletes

Sport specialization and sampling are two ways youth athletes can play sports. Athletes playing in college, at the Division III level, sample sports throughout their childhood instead of specializing in one sport. There is not a lot of specific research done for each Division in the NCAA. This study is a cross-sectional survey of students and athletes at SJFC, which is a small Division III school in Western New York. Using surveys, data was found that supports the research question that Division III athletes and students sampled sports throughout their childhoods rather than specializing. This question can help parents determine what kind of athlete they want their children to be in order for them to play at a higher competition level. Document Type Undergraduate Project Professor's Name Dr. Dane-Staples
Cholesteryl ester storage disease: relationship between molecular defects and in situ activity of lysosomal acid lipase.

The molecular defects in the LIPA gene encoding the lysosomal acid lipase (LAL) were investigated in two unrelated patients affected with cholesteryl ester storage disease (CESD), an autosomal recessive disorder associated with LAL-deficient activity. In cell lysates from both patients there was a severely reduced LAL activity. In a female patient, nucleotide sequencing of amplified LAL genomic DNA or reverse-transcribed mRNA demonstrated that she was a compound heterozygote for two previously reported mutations, a G --> A transition at position -1 of the exon 8 splice donor site, resulting in skipping of the complete exon 8, and a C923 --> T substitution leading to the replacement of His274 to Tyr. The second, male CESD patient was heterozygous for the splice junction mutation and a yet undescribed C --> T substitution at position 233, which introduces a premature in-frame termination codon. The functional consequences of these genetic alterations were evaluated for the first time by studying the catabolic turnover of radiolabeled cholesteryl oleate in intact cells. A lower in situ residual LAL activity was found in cells carrying the stop codon mutation than in cells having the His274 --> Tyr substitution. Since the severely reduced LAL activity was seen in cells from an adult patient with a mild CESD, we conclude that there is no simple direct correlation between the LAL molecular lesions and the biochemical and clinical phenotypes.
Varieties of "disordered" thinking on the Rorschach: findings in schizophrenic and nonschizophrenic patients.

Seventy-one schizophrenic and nonschizophrenic hospitalized patients were assessed on three scales for aspects indicative of a thinking disorder on the Rorschach: disruption of logical thought, irrelevant or personalized associations, and elaboration in affective terms. Each scale could be reliably scored according to the criteria described. The scales correlated significantly with other Rorschach scores suggestive of thought disorder. All three scales were significantly higher in schizophrenic patients than in depressed patients (f < .05). In addition, two of the three scales were related (p < .01) to ratings of bizarre behavior. The results suggest that the scales can be used to investigate the nature of thinking disorder.