Miracle-dz/UniFAR-FTUs huggingface dataset:
An extended Reynolds analogy for excited wavy instabilities of developing streamwise vortices with applications to scalar mixing intensification

Studies are presented to elucidate the role of steady streamwise vortex structures, initiated upstream from weak Görtler vortices in the absence of explicit vortex generators, and their excited nonlinear wavy instabilities in the intensification of scalar mixing in a spatially developing mixing region. While steady streamwise vortex flow gives rise to significant mixing enhancement, the excited nonlinear wavy instabilities, which in turn modify the basic three-dimensional streamwise vortices, give rise to further mixing intensification which is quantitatively assessed by a mixedness parameter. Possibility of similarity between the dimensionless streamwise momentum and scalar transport problems leading to an extended Reynolds analogy is sought. This similarity is shown earlier to hold for the steady streamwise vortex flow in the absence of nonlinear wavy instabilities (Liu & Sabry 1991 Proc. R. Soc. A 432, 1–12). In this paper, the momentum conservation equations for the nonlinear wavy or secondary instabilities together with the advected fluctuation scalar problems are examined in detail. The presence of the streamwise fluctuation pressure gradient, which prevents the similarity, is estimated in terms of the fluctuation dynamical pressure and its relative importance to advective transport. It is found from scaling that the fluctuating streamwise pressure gradient, though not completely negligible, is sufficiently unimportant so as to render similarity between fluctuation streamwise velocity and fluctuation temperature and concentration a distinct possibility. The scalar fluctuations are then inferable from the fluctuation streamwise velocity and that the Reynolds stresses of the nonlinear fluctuations and the scalar fluxes are also similar. The nonlinear instability-modified mean streamwise momentum and the modified mean heat and mass transport problems are also similar, thus providing a complete ‘Reynolds analogy’, rendering possible the interpretation of the scalar mixedness for a gaseous medium for which the Prandtl and Schmidt numbers are near unity. It is found that the nonlinearity of the wavy instability, which induces scalar fluxes modifying the mean scalar transport, further intensifies scalar mixedness over a significant streamwise region which is well above that achieved by the steady, unmodified streamwise vortices alone for the numerical example corresponding to the most amplified wavy-sinuous mode.
BATCH PROCESSING IN A GLASS FURNACE

In a glass furnace solid batches of material are fed into a chamber and radiation heating applied. An individual batch is melted over the course of several minutes to form molten glass. A travelling front within the batch designates the progress of the melting, a process characterized by multiple radiation reflections. This results in an effective conductivity within the melting zone that is significantly larger than that in the unmelted batch. Approximations based on these disparate conductivities enable accurate explicit expressions for the almost constant melting front speed and the associated temperature profile to be derived. Our results compare favourably with existing numerical simulations of the process, with the advantage of being both analytic and relatively simple. These predictions may be useful in suggesting how a furnace might be most effectively controlled under varying batch conditions, as well as ensuring the quality of the glass sheets produced.
Gait and falls in cerebral small vessel disease: a systematic review and meta-analysis

Abstract Background Gait impairment contributes to falls and frailty. Some studies suggest that cerebral small vessel disease (CSVD) is associated with gait impairment in the general population. We systematically reviewed and meta-analysed the literature on associations of CSVD with gait impairment and falls. Methods The protocol was published in PROSPERO (CRD42021246009). Searches of Medline, Cochrane and Embase databases were conducted on 30 March 2022. Cross-sectional and longitudinal studies of community-dwelling adults were included, reporting relationships between diagnosis or neuroimaging markers of CSVD and outcomes related to gait or falls. Partial correlation coefficients were calculated and pooled using a random-effects model for meta-analysis. Results The search retrieved 73 studies (53 cross-sectional; 20 longitudinal). Most studies reported an association between CSVD and gait impairments or falls risk: 7/7 studies on CSVD score or diagnosis, 53/67 studies on white matter hyperintensities (WMHs), 11/21 studies on lacunar infarcts, 6/15 studies on cerebral microbleeds and 1/5 studies on perivascular spaces. Meta-analysis of 13 studies found that higher WMH volume was mildly correlated with lower gait speed, in all studies (r = −0.23, 95% confidence interval: −0.33 to −0.14, P < 0.0001). However, there was significant heterogeneity between studies (I2 = 82.95%; tau2 = 0.02; Q = 79.37, P < 0.0001), which was unexplained by variation in age, sex, study quality or if the study adjusted for age. Conclusions Findings suggest that CSVD severity is associated with gait impairment, history of falls and risk of future falls. Prevention of CSVD should be part of a comprehensive public health strategy to improve mobility and reduce risk of falls in later life.
Measurement of Cerebral Perfusion Indices from the Early Phase of [18F]MK6240 Dynamic Tau PET Imaging

Visual Abstract 6-(fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F]MK6240) has high affinity and selectivity for hyperphosphorylated tau and readily crosses the blood–brain barrier. This study investigated whether the early phase of [18F]MK6240 can be used to provide a surrogate index of cerebral perfusion. Methods: Forty-nine subjects who were cognitively normal (CN), had mild cognitive impairment (MCI), or had Alzheimer’s disease (AD) underwent paired dynamic [18F]MK6240 and [11C]Pittsburgh compound B (PiB) PET, as well as structural MRI to obtain anatomic information. Arterial blood samples were collected in a subset of 24 subjects for [18F]MK6240 scans to derive metabolite-corrected arterial input functions. Regional time–activity curves were extracted using atlases available in the Montreal Neurologic Institute template space and using FreeSurfer. The early phase of brain time–activity curves was analyzed using a 1-tissue-compartment model to obtain a robust estimate of the rate of transfer from plasma to brain tissue, K1 (mL⋅cm−3⋅min−1), and the simplified reference tissue model 2 was investigated for noninvasive estimation of the relative delivery rate, R1 (unitless). A head-to-head comparison with R1 derived from [11C]PiB scans was performed. Grouped differences in R1 were evaluated among CN, MCI, and AD subjects. Results: Regional K1 values suggested a relatively high extraction fraction. R1 estimated noninvasively from simplified reference tissue model 2 agreed well with R1 calculated indirectly from the blood-based compartment modeling (r = 0.99; mean difference, 0.024 ± 0.027), suggesting that robust estimates were obtained. R1 measurements obtained with [18F]MK6240 correlated strongly and overall agreed well with those obtained from [11C]PiB (r = 0.93; mean difference, −0.001 ± 0.068). Statistically significant differences were observed in regional R1 measurements among CN, MCI, and AD subjects, notably in the temporal and parietal cortices. Conclusion: Our results provide evidence that the early phase of [18F]MK6240 images may be used to derive a useful index of cerebral perfusion. The early and late phases of a [18F]MK6240 dynamic acquisition may thus offer complementary information about the pathophysiologic mechanisms of the disease.
Visualization and characterization of slider-disk interactions in dynamic load/unload processes

A novel visualization technique proposed by the authors was used to study slider-disk interactions during loading and unloading operations. The outcomes of the study prove that the visualization technique is a convenient, effective, and promising method for the investigation of slider-disk interactions. The performance of designed loading/unloading system can be evaluated effectively in a very short period of time. Many details, such as contact mode, type of contact, and so on, which have been invisible before, are now observable and have been revealed in this study.
Consumer preferences for telehealth in Australia: A discrete choice experiment

This study aims to elicit consumer preferences regarding telehealth and face-to-face consultations in Australia. It used a discrete choice experiment, presenting participants with a series of hypothetical choices, and based on their responses, infer what is most important to them. Data were analysed using conditional logit regression and latent class analysis. A total of 1,025 participants completed the survey, considering four different clinical scenarios. Face-to-face contacts were, on average, preferred to either telephone or video services. However, telehealth was identified as an attractive option if it prevents significant travel and can be conducted with a familiar doctor. Participants were strongly driven by cost, particularly greater than $30. Telehealth was least preferred for situations involving a new and unknown physical symptom, and relatively more preferred for surgical follow-up. The latent class analysis demonstrates only 15.9% of participants appeared unwilling to consider telehealth. The findings of this study suggest that meeting the needs of the Australian population requires a blended approach to service delivery, with telehealth being valued in a range of clinical scenarios. Price sensitivity was evident, therefore if telehealth services can be delivered with lower patient cost, then they are likely to be attractive.
The Role of Shame in Schizophrenia Delusion

Abstract Through a strictly dimensional approach, the present study aimed at evaluating the interplay between cognitive-perceptual disturbances and emotional dispositions, particularly shame proneness, in schizophrenia delusion. One hundred one outpatients with schizophrenia were administered the Peters et al. Delusions Inventory, the Referential Thinking Scale (REF), the Magical Ideation Scale (MIS), the Perceptual Aberration Scale (PAS), the Positive and Negative Affect Schedule and the Experiences of Shame Scale (ESS). The severity of delusional ideation was positively related to all the cognitive-perceptual scales (REF, MIS, and PAS) and to shame proneness (ESS). Referential thinking (REF) emerged as the strongest predictor of delusion severity. The experience of shame played a mediation role in the relationship between cognitive-perceptual traits and delusional severity. These data suggest that severity delusion in schizophrenia depends, at least in part, on a complex interplay between cognitive-perceptual disturbances and experiences of shame.
Episodic memory and personal semantics as triggers of nostalgia: its relationships between abstraction of memory content and temporal distance

ABSTRACT Nostalgia, an autobiographically relevant positive emotion, is a sentimental longing or wistful affection for the past. Autobiographical memory, which is one of the cognitive bases of nostalgia, includes both abstract semantic and detailed episodic memories. Recent studies have defined and classified memories that are located between semantic and episodic memory as personal semantics. Although autobiographical memory and personal semantics range over a continuum, past nostalgia research has not focused on or controlled them. In two experiments, undergraduate students retrieved episodic memory and personal semantics and rated cognitive and affective items. The intensity of nostalgia differed according to the types of memory content and temporal distance of the memory from the present. These results revealed that not only unique events but also repeated events and autobiographical facts induced nostalgia; furthermore, repeated events from both the distant and recent past (primary and high school, respectively) consistently induced relatively greater nostalgia, but in some cases, they were not significantly different from other types of memory (i.e., unique events and autobiographical facts). These findings suggest that both episodic memory and personal semantics are involved in the occurrence of nostalgia.
Multiple intrinsic and extrinsic drivers influence the quantity and quality components of seed dispersal effectiveness in the rare shrub Lindera subcoriacea

Information about seed dispersal effectiveness (SDE) for plant species of conservation concern is rarely available to inform management strategies and actions. For Lindera subcoriacea (bog spicebush, Lauraceae), a rare endemic dioecious shrub of the southeastern United States, we examined the influence of two intrinsic and five extrinsic drivers on the number and proportion of seeds either dispersed, or predated pre- and post-dispersal. The number of seeds dispersed characterizes the quantitative component of SDE, while pre- and post-dispersal seed predation can affect the qualitative component of SDE. Using fruit counts, seed traps, and seed removal depots over multiple years, we estimated that approximately 28% of L. subcoriacea seeds are lost to pre-dispersal predation, 69% of seeds are dispersed, 3% of seeds fail to disperse, and 65% of dispersed seeds are predated post-dispersal. We observed substantial variation in these three processes among individuals. We also found that both intrinsic (plant height, crop size) and extrinsic (understory cover, time since last fire, conspecific fruiting neighborhood, substrate) drivers differentially influenced the three processes. We identified four generalist, seasonally frugivorous, avian visitors at fruiting individuals that likely act as variably effective dispersers, while the Northern Cardinal (Cardinalis cardinalis L.) is a seed predator. Rodent granivores were important pre- and post-dispersal seed predators. The magnitude of our pre-dispersal and post-dispersal seed predation estimates suggest that, given the low fecundity of L. subcoriacea, conservation strategies should emphasize facilitating dispersal and reducing the effects of seed predation.
The future scalability of pH-based genome sequencers: A theoretical perspective

Sequencing of human genome is an essential prerequisite for personalized medicine and early prognosis of various genetic diseases. The state-of-art, high-throughput genome sequencing technologies provide improved sequencing; however, their reliance on relatively expensive optical detection schemes has prevented wide-spread adoption of the technology in routine care. In contrast, the recently announced pH-based electronic genome sequencers achieve fast sequencing at low cost because of the compatibility with the current microelectronics technology. While the progress in technology development has been rapid, the physics of the sequencing chips and the potential for future scaling (and therefore, cost reduction) remain unexplored. In this article, we develop a theoretical framework and a scaling theory to explain the principle of operation of the pH-based sequencing chips and use the framework to explore various perceived scaling limits of the technology related to signal to noise ratio, well-to-well crosst.
Normative values of hand grip strength in a large unselected Chinese population: Evidence from the China National Health Survey

Hand grip strength (HGS) is a powerful indicator of sarcopenia and other adverse health outcomes. Normative values for HGS for general Chinese people with a broad age spectrum are lacking. This study aims to establish normative values of HGS and explore the correlations between HGS and body composition among unselected people aged 8–80 in China.
Autoantibodies Recognizing Specificity Protein 4 Co‐occur With Anti–Transcription Intermediary Factor 1 and Are Associated With Distinct Clinical Features and Immunogenetic Risk Factors in Juvenile Myositis

Autoantibodies recognizing specificity protein 4 (Sp4) were recently discovered in adults with idiopathic inflammatory myopathies (IIM). Anti‐Sp4 autoantibodies co‐occurred in patients with anti–transcription intermediary factor 1 (anti‐TIF1) autoantibody‐positive dermatomyositis (DM) and were associated with a reduced risk of cancer. In the present study, the prevalence and clinical features associated with anti‐Sp4 autoantibodies in juvenile‐onset IIM were investigated.
A general approach to representing multifaceted personality constructs: Application to state self‐esteem

This article proposes a framework for representing personality constructs at four levels of abstraction. The total aggregation model is the composite formed by the sum of scores on all items in a scale. The partial aggregation model treats separate dimensions of a personality construct as indicators of a single latent variable, with each dimension being an aggregation of items. The partial disaggregation model represents each dimension as a separate latent variable, either freely correlated with the other dimensions or loading on one or more than one higher order factor; the measures of the dimensions are multiple indicators formed as aggregates of subsets of items. The total disaggregation model also represents each dimension as a separate latent variable but, unlike the partial disaggregation model, uses each item in the scale as an indicator of its respective factor. Illustrations of the models are provided on the State Self‐Esteem Scale—including tests of psychometric properties, invariance, and gener.
The pre-pregnancy fasting blood glucose, glycated hemoglobin and lipid profiles as blood biomarkers for gestational diabetes mellitus: evidence from a multigenerational cohort study

Abstract Background Early prevention of gestational diabetes mellitus (GDM) is important to reduce the risk of adverse pregnancy outcomes and post-pregnancy cardiometabolic risk in women and offspring over the life course. This study aimed to investigate some blood biomarkers before pregnancy as GDM predictors. Methods We investigated the prospective association of blood biomarkers before pregnancy and GDM risk among women from the Mater-University of Queensland Study of Pregnancy (MUSP) cohort. A multiple logistic regression model was applied to estimate the odds of experiencing GDM by blood biomarkers. Results Out of 525 women included in this study, the prevalence of GDM was 7.43%. There was an increased risk of experiencing GDM among women who experienced obesity (Odds ratio = OR 2.4; 95% confidence interval = CI 1.6–3.7), had high fasting blood glucose (OR = 2.2; 95% CI = 1.3–3.8), high insulin (OR = 1.1; 95% CI = 1.0–1.2), high insulin resistance (OR = 1.2; 95% CI = 1.0–1.3) and low high-density lipoprotein (OR = 0.2; 95% CI = 0.1–0.7) before pregnancy. Adjustment for potential confounders, such as age, marital status, and BMI did not attenuate these associations substantially. Conclusion The pre-pregnancy fasting blood glucose, insulin, and insulin resistance were independent predictors of GDM. They may be used as early markers for predicting the incidence of GDM.
Direct anterior approach versus posterolateral approach for total hip arthroplasty in the treatment of femoral neck fractures in elderly patients: a meta-analysis and systematic review

Abstract Objective The purpose of this meta-analysis was to evaluate the postoperative clinical outcomes of elderly patients who underwent the direct anterior approach (DAA) versus those who received posterolateral approach (PLA) for total hip arthroplasty (THA) in the treatment of femoral neck fractures. Methods An electronic search was conducted in databases including PubMed, Embase, Web of Science, the Cochrane Library, and CNKI from their inception to January 2022. We calculated the odds ratio (OR) and mean difference (MD) with 95% confidence intervals (CIs) to assess the effect of DAA compared to PLA for the management of total hip arthroplasty (THA) in elderly patients using the dichotomous or continuous method with a random or fixed-effect model. Results 15 studies involving 1284 patients were included; 640 patients receiving DAA and 644 patients receiving PLA. DAA had a longer surgery duration than PLA [WMD = 9.41, 95% CI (4.64, 14.19), I2=95.5%]; The amount of postoperative drainage [WMD= −3.88, 95% CI (−5.59, −2.17), I2=98.3%], length of incision [WMD= −3.88, 95% CI (−5.59, −2.17), I2=98.3%], blood loss [WMD= −3.88, 95% CI (−5.59, −2.17), I2=98.3%], hospitalization time [WMD= −3.88, 95% CI (−5.59, −2.17), I2=98.3%], and postoperative bedtime [WMD = −5.56,95% CI (−7.11, −4.01), I2=99.0%], were similar between the two groups (p < 0.05). The HHS at 1 month, 12 months postoperatively [WMD = 7.58, 95%CI (5.70,9.46), I2=89.5%; WMD= 2.56, 95%CI 0.11,5.00, I2=93.2%] and the incidence of LFCN in patients were higher in the DAA group (OR = 2.91, 95% CI 1.26 to 6.71, I2=0.0%), while fewer patients in the DAA group suffered from postoperative dislocation than in the PLA group (OR = 0.26, 95% CI 0.11 to 0.60, I2=0.0%). No significant difference was observed in HHS at 1 week, 3 months, and 6 months postoperatively, VAS postoperatively at each time point, acetabular anteversion angle, acetabular abduction angle, wound infection, deep vein thrombosis, and intraoperative fracture (p > 0.05). Conclusions DAA offers a quicker functional recovery and is less invasive with an earlier return to daily activities in older THA patients than PLA. However, DAA was found to be associated with a high incidence of lateral femoral cutaneous nerve injury and a low incidence of postoperative dislocation. Key messages The present study aims to evaluate the clinical outcomes in elderly patients receiving DAA versus PLA for THA in the treatment of femoral neck fractures by mate-analysis. DAA offers a quicker functional recovery and is less invasive with an earlier return to daily activities in older THA patients. No significant difference was observed between the colchicine and comparators in terms of the need for HHS at 1 week, 3 months, and 6 months postoperatively, VAS postoperatively, acetabular anteversion angle, acetabular abduction angle, and complications (wound infection, deep vein thrombosis, and intraoperative fracture).
Psychological Grit Moderates the Relation between Lifetime Stressor Exposure and Functional Outcomes among HIV-seropositive and HIV-seronegative Adults.

The ability to maintain functional independence throughout the lifespan may be diminished among medically compromised and chronically stressed populations. People living with HIV (PLWH) are more likely to demonstrate functional impairment and report greater exposure to lifetime and chronic stressors than their seronegative counterparts. It is well-known that exposure to stressors and adversity is associated with functional impairment outcomes. However, to our knowledge, no studies have examined how protective factors such as psychological grit mitigate the negative effects of lifetime and chronic stressor exposure on functional impairment, and how this association differs by HIV-status. To address this issue, we studied associations between lifetime and chronic stressor exposure, grit, and functional impairment in 176 African American and non-Hispanic White HIV-seropositive (n = 100) and HIV-seronegative (n = 76) adults, aged 24-85 (M = 57.28, SD = 9.02). As hypothesized, HIV-seropositive status and lower grit, but not lifetime stressor exposure, were independently associated with more functional impairment. Moreover, there was a significant three-way interaction between HIV-status, grit, and lifetime stressor exposure, b = 0.07, p = . 025, 95% CI [0.009, 0.135]. Specifically, lifetime stressor exposure was related to more functional impairment for HIV-seronegative-but not HIV-seropositive-adults who reported low levels of grit. These findings suggest that the protective effects of grit may differ across populations at risk for functional impairment. This article is protected by copyright. All rights reserved.