Miracle-dz/UniFAR-FTUs huggingface dataset:
Idiopathic noncirrhotic portal hypertension in dogs: 33 cases (1982-1998).

OBJECTIVE To describe clinical signs, diagnostic findings, and outcome in dogs with idiopathic intrahepatic portal hypertension. DESIGN Retrospective study. ANIMALS 33 dogs. PROCEDURE Medical records of dogs with portal hypertension of intra-abdominal origin were reviewed. Dogs with intra-abdominal portal hypertension of vascular causes or with hepatic histopathologic changes consistent with severe diffuse hepatobiliary disease were excluded. History and results of physical examination, clinicopathologic tests, diagnostic imaging studies, histologic examination, and treatment were summarized. Outcome was determined in 26 dogs. RESULTS Dogs were referred most often because of ascites, intermittent vomiting or diarrhea, and polydipsia of several months' duration. Microcytosis, high serum alkaline phosphatase and alanine transaminase activities, hepatic dysfunction, urine specific gravity < or = 1.021, and abdominal transudate were the predominant clinicopathologic features. Microhepatia, abdominal effusion, and multiple anomalous venous anastomoses were the major findings of diagnostic imaging. Hepatic histopathologic changes were consistent with idiopathic noncirrhotic portal hypertension and were indistinguishable from those of dogs with surgically created portocaval anastomosis. Outcome was determined for 19 dogs released from hospital; 13 dogs remained healthy with mostly palliative treatment for periods of 5 months to 9 years. CONCLUSIONS AND CLINICAL RELEVANCE The clinical signs, clinicopathologic test results, portal pressure, and gross appearance of the liver of dogs with idiopathic noncirrhotic portal hypertension may be identical to those of dogs with cirrhosis; therefore liver biopsy is crucial. Because the prognosis for idiopathic noncirrhotic portal hypertension is generally favorable, owners of affected dogs should be discouraged from choosing euthanasia.
A Typology of Socio-Economic Advantage and Disadvantage in Australia's Large Non-Metropolitan Cities, Towns and Regions

Abstract Australia's large regional cities and towns display a wide variation in their adjustment to the socio-economic transitions that have occurred over the past decade. In terms of socio-economic advantage and disadvantage, these changes, often associated with globalisation, wider economic and technological restructuring, the changing demographics of the population and shifts in public policy, are not evenly dispersed across non-metropolitan regions. Such outcomes have been discussed across a variety of academic disciplines using a variety of data and methods, and the research undertaken has provided a useful grounding for contemporary studies both theoretically and methodologically. Analysis of new data provides an opportunity to extend and update our understanding. This paper presents an analysis of secondary data aimed at analysing non-metropolitan cities, towns and regions based on differential levels of socio-economic performance. Using an alternative clustering method, this paper groups non-metropolitan cities, towns and regions according to the degree to which they share similar socio-economic and demographic outcomes. These clusters form the basis of a typology representing the range of socio-economic and demographic outcomes at the non-metropolitan level.
The Health Care Cost of Dying: A Population-Based Retrospective Cohort Study of the Last Year of Life in Ontario, Canada

Background Coordinated and appropriate health care across sectors is an ongoing challenge, especially at the end-of-life. Population-level data on end-of-life health care use and cost, however, are seldom reported across a comprehensive array of sectors. Such data will identify the level of care being provided and areas where care can be optimized. Methods This retrospective cohort study identified all deaths in Ontario from April 1, 2010 to March 31, 2013. Using population-based health administrative databases, we examined health care use and cost in the last year of life. Results Among 264,755 decedents, the average health care cost in the last year of life was $53,661 (Quartile 1-Quartile 3: $19,568-$66,875). The total captured annual cost of $4.7 billion represents approximately 10% of all government-funded health care. Inpatient care, incurred by 75% of decedents, contributed 42.9% of total costs ($30,872 per user). Physician services, medications/devices, laboratories, and emergency rooms combined to less than 20% of total cost. About one-quarter used long-term-care and 60% used home care ($34,381 and $7,347 per user, respectively). Total cost did not vary by sex or neighborhood income quintile, but were less among rural residents. Costs rose sharply in the last 120 days prior to death, predominantly for inpatient care. Interpretation This analysis adds new information about the breadth of end-of-life health care, which consumes a large proportion of Ontario’s health care budget. The cost of inpatient care and long-term care are substantial. Introducing interventions that reduce or delay institutional care will likely reduce costs incurred at the end of life.
PCR-Independent Detection of Bacterial Species-Specific 16S rRNA at 10 fM by a Pore-Blockage Sensor

A PCR-free, optics-free device is used for the detection of Escherichia coli (E. coli) 16S rRNA at 10 fM, which corresponds to ~100–1000 colony forming units/mL (CFU/mL) depending on cellular rRNA levels. The development of a rapid, sensitive, and cost-effective nucleic acid detection platform is sought for the detection of pathogenic microbes in food, water and body fluids. Since 16S rRNA sequences are species specific and are present at high copy number in viable cells, these nucleic acids offer an attractive target for microbial pathogen detection schemes. Here, target 16S rRNA of E. coli at 10 fM concentration was detected against a total RNA background using a conceptually simple approach based on electromechanical signal transduction, whereby a step change reduction in ionic current through a pore indicates blockage by an electrophoretically mobilized bead-peptide nucleic acid probe conjugate hybridized to target nucleic acid. We investigated the concentration detection limit for bacterial species-specific 16S rRNA at 1 pM to 1 fM and found a limit of detection of 10 fM for our device, which is consistent with our previous finding with single-stranded DNA of similar length. In addition, no false positive responses were obtained with control RNA and no false negatives with target 16S rRNA present down to the limit of detection (LOD) of 10 fM. Thus, this detection scheme shows promise for integration into portable, low-cost systems for rapid detection of pathogenic microbes in food, water and body fluids.
Private information retrieval for coded storage

Private information retrieval scheme for coded data storage is considered in this paper. We focus on the case where the size of each data record is large and hence only the download cost (but not the upload cost for transmitting retrieval queries) is of interest. We prove that the tradeoff between storage cost and retrieval/download cost depends on the number of data records in the system. We propose a class of linear storage codes and retrieval schemes, and derive conditions under which our schemes are error-free and private. Tradeoffs between the storage cost and retrieval costs are also obtained.
Influence of Continuous Positive Airway Pressure on Outcomes of Rehabilitation in Stroke Patients With Obstructive Sleep Apnea

Background and Purpose— In stroke patients, obstructive sleep apnea (OSA) is associated with poorer functional outcomes than in those without OSA. We hypothesized that treatment of OSA by continuous positive airway pressure (CPAP) in stroke patients would enhance motor, functional, and neurocognitive recovery. Methods— This was a randomized, open label, parallel group trial with blind assessment of outcomes performed in stroke patients with OSA in a stroke rehabilitation unit. Patients were assigned to standard rehabilitation alone (control group) or to CPAP (CPAP group). The primary outcomes were the Canadian Neurological scale, the 6-minute walk test distance, sustained attention response test, and the digit or spatial span-backward. Secondary outcomes included Epworth Sleepiness scale, Stanford Sleepiness scale, Functional Independence measure, Chedoke McMaster Stroke assessment, neurocognitive function, and Beck depression inventory. Tests were performed at baseline and 1 month later. Results— Patients assigned to CPAP (n=22) experienced no adverse events. Regarding primary outcomes, compared to the control group (n=22), the CPAP group experienced improvement in stroke-related impairment (Canadian Neurological scale score, P<0.001) but not in 6-minute walk test distance, sustained attention response test, or digit or spatial span-backward. Regarding secondary outcomes, the CPAP group experienced improvements in the Epworth Sleepiness scale (P<0.001), motor component of the Functional Independence measure (P=0.05), Chedoke-McMaster Stroke assessment of upper and lower limb motor recovery test of the leg (P=0.001), and the affective component of depression (P=0.006), but not neurocognitive function. Conclusions— Treatment of OSA by CPAP in stroke patients undergoing rehabilitation improved functional and motor, but not neurocognitive outcomes. Clinical Trial Registration Information— URL: http://www.clinicaltrials. gov. Unique identifier: NCT00221065.
Value Elimination: Bayesian Interence via Backtracking Search

We present Value Elimination, a new algorithm for Bayesian Inference. Given the same variable ordering information, Value Elimination can achieve performance that is within a constant factor of variable elimination or recursive conditioning, and on some problems it can perform exponentially better, irrespective of the variable ordering used by these algorithms. Value Elimination's other features include: (1) it can achieve the same space-time tradeoff guarantees as recursive conditioning; (2) it can utilize all of the logical reasoning techniques used in state of the art SAT solvers; these techniques allow it to obtain considerable extra mileage out of zero entries in the CPTs; (3) it can be naturally and easily extended to take advantage of context specific structure; and (4) it supports dynamic variable orderings which might be particularly advantageous in the presence of context specific structure. We have implemented a version of Value Elimination that demonstrates very promising performance, often being one or two orders of magnitude faster than a commercial Bayes inference engine, despite the fact that it does not as yet take advantage of context specific structure.
Lactoylglutathione lyase, a critical enzyme in methylglyoxal detoxification, contributes to survival of Salmonella in the nutrient rich environment

Glyoxalase I which is synonymously known as lactoylglutathione lyase is a critical enzyme in methylglyoxal (MG) detoxification. We assessed the STM3117 encoded lactoylglutathione lyase (Lgl) of Salmonella Typhimurium, which is known to function as a virulence factor, due in part to its ability to detoxify methylglyoxal. We found that STM3117 encoded Lgl isomerises the hemithioacetal adduct of MG and glutathione (GSH) into S-lactoylglutathione. Lgl was observed to be an outer membrane bound protein with maximum expression at the exponential growth phase. The deletion mutant of S. Typhimurium (Δlgl) exhibited a notable growth inhibition coupled with oxidative DNA damage and membrane disruptions, in accordance with the growth arrest phenomenon associated with typical glyoxalase I deletion. However, growth in glucose minimal medium did not result in any inhibition. Endogenous expression of recombinant Lgl in serovar Typhi led to an increased resistance and growth in presence of external MG. Being a metalloprotein, Lgl was found to get activated maximally by Co2+ ion followed by Ni2+, while Zn2+ did not activate the enzyme and this could be attributed to the geometry of the particular protein-metal complex attained in the catalytically active state. Our results offer an insight on the pivotal role of the virulence associated and horizontally acquired STM3117 gene in non-typhoidal serovars with direct correlation of its activity in lending survival advantage to Salmonella spp.
On Uncertain Graphs Modeling and Queries

Large-scale, highly-interconnected networks pervade both our society and the natural world around us. Uncertainty, on the other hand, is inherent in the underlying data due to a variety of reasons, such as noisy measurements, lack of precise information needs, inference and prediction models, or explicit manipulation, e.g., for privacy purposes. Therefore, uncertain, or probabilistic, graphs are increasingly used to represent noisy linked data in many emerging application scenarios, and they have recently become a hot topic in the database research community. While many classical graph algorithms such as reachability and shortest path queries become #P-complete, and hence, more expensive in uncertain graphs; various complex queries are also emerging over uncertain networks, such as pattern matching, information diffusion, and influence maximization queries. In this tutorial, we discuss the sources of uncertain graphs and their applications, uncertainty modeling, as well as the complexities and algorithmic advances on uncertain graphs processing in the context of both classical and emerging graph queries. We emphasize the current challenges and highlight some future research directions.
Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

The AKT2 gene is one of the human homologues of v‐akt, the transduced oncogene of the AKT8 virus, which induces lymphomas in mice. In previous studies, AKT2, which codes for a serine‐threonine protein kinase, was shown to be amplified and overexpressed in some human ovarian carcinoma cell lines and amplified in primary tumors of the ovary. To confirm and extend these findings, we conducted a large‐scale, multicenter study of AKT2 alterations in ovarian and breast cancer. Southern‐blot analysis demonstrated AKT2 amplification in 16 of 132 (12.1%) ovarian carcinomas and in 3 of 106 (2.8%) breast carcinomas. No AKT2 alteration was detected in 24 benign or borderline tumors. Northern‐blot analysis revealed overexpression of AKT2 in 3 of 25 fresh ovarian carcinomas which were negative for AKT2 amplification. The difference in the incidence of AKT2 alterations in ovarian and breast cancer suggests a specific role for this gene in ovarian oncogenesis. No significant association was found between AKT2 amplification and amplification of the proto‐oncogenes MYC and ERBB2, suggesting that amplification of AKT2 defines an independent subset of breast and ovarian cancers. Ovarian cancer patients with AKT2 alterations appear to have a poor prognosis. Amplification of AKT2 was especially frequent in undifferentiated tumors (4 of 8, p = 0.019), suggesting that AKT2 alterations may be associated with tumor aggressiveness. © 1995 Wiley‐Liss, Inc.
Cytometrical Evidence That the Loss of Seed Weight in theminiature1 Seed Mutant of Maize Is Associated with Reduced Mitotic Activity in the Developing Endosperm1

“If you know a thing only qualitatively, you know it no more than vaguely. If you know it quantitatively—grasping some numerical measure that distinguishes it from an infinite number of other possibilities—you are beginning to know it deeply. ” (C. Sagan, Billions and Billions, 1997). Using
Culture and Empirically Supported Treatments: On the Road to a Collision?

The dual influence of culturally sensitive therapies (CSTs) and empirically supported treatments (ESTs) on clinical practitioners has grown quickly in the United States. While CST advocates have been driven by the need to provide culturally diverse populations with services that are consistent with their cultural characteristics, practitioners of ESTs have striven to empirically demonstrate the benefits of psychotherapy. However, as EST's influence grows, it may increasingly threaten CST's advances. Some assumptions underlying the development of ESTs are not culturally sensitive and can be detrimental to the well-being of culturally diverse patients. This article highlights these assumptions in four interrelated areas and provides suggestions to overcome these shortcomings. Cultural assumptions and methodological implications of ESTs are presented, as well as some suggestions on how to broaden their cultural understandings. To conclude, some general recommendations on how to start bridging the gap between ESTs and CSTs are proposed.
Strategies for therapy of retinal diseases using systemic drug delivery: relevance of transporters at the blood–retinal barrier

Introduction: There is an increasing need for managing rapidly progressing retinal diseases because of the potential loss of vision. Although systemic drug administration is one possible route for treating retinal diseases, retinal transfer of therapeutic drugs from the circulating blood is strictly regulated by the blood–retinal barrier (BRB). Areas covered: This review discusses the constraints and challenges of drug delivery to the retina. In addition, this article discusses the properties of drugs and the conditions of the BRB that affect drug permeability. The reader will gain insights into the strategies for developing therapeutic drugs that are able to cross the BRB for treating retinal diseases. Further, the reader will gain insights into the role of BRB physiology including barrier functions, and the effect of influx and efflux transporters on retinal drug delivery. Expert opinion: When designing and selecting optimal drug candidates, it's important to consider the fact that they should be recognized by influx transporters and that efflux transporters at the BRB should be avoided. Although lipophilic cationic drugs are known to be transported to the brain across the blood–brain barrier, verapamil transport to the retina is substantially higher than to the brain. Therefore, lipophilic cationic drugs do have a great ability to increase influx transport across the BRB.
The Social Context of Effective Schools

This article analyzes differences in the operation of school effectiveness factors in high- and low-SES effective schools. Observable differences are found on several effectiveness variables. The social context of the effective schools appears to influence the breadth of the curriculum, the allocation and use of instructional time, the instructional leadership role of the principal, the nature of the school reward system, and the type of expectations embedded in school policies and practices. These findings, though tentative, indicate that practitioners should not treat the well-publicized effectiveness factors as generalizable to all school settings. In addition, the results suggest that researchers concerned with understanding the process of effective schooling should focus on the manner in which these schools translate contextual expectations into school policies and classroom practices.
Team adaptation: A fifteen-year synthesis (1998–2013) and framework for how this literature needs to “adapt” going forward

Organizations increasingly operate within dynamic environments that require them to adapt. To respond quickly and effectively to acute or on-going change, many organizations use teams to help them remain competitive. Accordingly, the topic of team adaptation has become more prominent within the broader organizational team literature. Given the wealth of knowledge that has been accumulated, we consider what has been learned to date. However, even with the increased attention to team adaptation within the literature, not all teams are created equal in terms of their capacity for adaptability. Thus, we review factors that serve as antecedents of team adaptation, the process of adaptation, and the resulting adaptive outcomes. Finally, we suggest future directions for research and practice as we introduce a conceptual framework, whereby the focus of a team’s adaptation process is impacted by the type and severity of the disruption or trigger that gives rise to the need for adaptation.
Constitutive Expression of AID Leads to Tumorigenesis

Genome stability is regulated by the balance between efficiencies of the repair machinery and genetic alterations such as mutations and chromosomal rearrangements. It has been postulated that deregulation of class switch recombination (CSR) and somatic hypermutation (SHM), which modify the immunoglobulin (Ig) genes in activated B cells, may be responsible for aberrant chromosomal translocations and mutations of non-Ig genes that lead to lymphocyte malignancy. However, the molecular basis for these genetic instabilities is not clearly understood. Activation-induced cytidine deaminase (AID) is shown to be essential and sufficient to induce both CSR and SHM in artificial substrates in fibroblasts as well as B cells. Here we show that constitutive and ubiquitous expression of AID in transgenic mice caused both T cell lymphomas and dysgenetic lesions of epithelium of respiratory bronchioles (micro-adenomas) in all individual mice. Point mutations, but not translocations, were massively introduced in expressed T cell receptor (TCR) and c-myc genes in T lymphoma cells. The results indicate that AID can mutate non-Ig genes including oncogenes, implying that aberrant AID expression could be a cause of human malignancy.
EEG correlates of acute nicotinic and muscarinic cholinergic blockade: separate and combined administration of mecamylamine and scopolamine in normal human subjects

Anticholinergic drugs have been proposed as a possible acute model for human electroencephalographic (EEG) studies focused on dementia but the interactive effects of muscarinic and nicotinic cholinergic receptor system blockade on the regulation of electrocortical activity has yet to be examined. EEG recordings were carried out in 15 normal subjects before and after the double‐blind acute administration of a placebo, a centrally acting nicotinic blocker (20 mg of mecamylamine), a centrally acting muscarinic blocker (0·6 mg of scopolamine) and a combination dose of mecamylamine and scopolamine. Mecamylamine decreased absolute and relative beta power and increased relative theta power. Scopolamine increased relative power in both theta and beta frequency bands. Mecamylamine produced greater theta increments than scopolamine, while combined administration of the two central blockers induced changes similar to that observed with mecamylamine administered alone. Results are discussed in relation to electrocerebral activity in normal and pathological aging. © 1997 John Wiley & Sons, Ltd.
A Fast Method for Vanishing Point Estimation and Tracking and Its Application in Road Images

A fast method for vanishing point (VP) estimation and tracking in road images and its application for lane detection are investigated in this paper. After determine the region of interest of the road images, we use 'Sobel' operator to detect boundaries. Then the boundary image is transformed to the Hough space by Hough transform. We proposed a Gaussian predication model on the basis of the latest vanishing point to predicate the current VP, and we constructed an objective function including the linear segment intensity and the predicated VP, subsequently the optimal position of the VP is estimated through the least square method. The computational complexity of the estimation algorithm is O(n), which can operate in real time. We test our algorithm on many structured road and semi-structured road images, the results show that it can robustly determine the VP position regardless the disturbance of around pedestrian, crowd and vehicles. Moreover, experiments on PETS2001 dataset show its application to the road lane detection for the driver assistant system