Miracle-dz/UniFAR-FTUs huggingface dataset:
Importance of Probiotics in Fish Aquaculture: Towards the Identification and Design of Novel Probiotics

Aquaculture is a growing industry worldwide, but it faces challenges related to animal health. These challenges include infections by parasites, bacteria, and viral pathogens. These harmful pathogens have devastating effects on the industry, despite efforts to control them through vaccination and antimicrobial treatments. Unfortunately, these measures have proven insufficient to address the sanitary problems, resulting in greater environmental impact due to the excessive use of antimicrobials. In recent years, probiotics have emerged as a promising solution to enhance the performance of the immune system against parasitic, bacterial, and viral pathogens in various species, including mammals, birds, and fish. Some probiotics have been genetically engineered to express and deliver immunomodulatory molecules. These promote selective therapeutic effects and specific immunization against specific pathogens. This review aims to summarize recent research on the use of probiotics in fish aquaculture, with a particular emphasis on genetically modified probiotics. In particular, we focus on the advantages of using these microorganisms and highlight the main barriers hindering their widespread application in the aquaculture industry.
Economic Threats, Political and National Identification Predict Affective Polarization: Longitudinal Evidence From Spain

Economic threats, along with political identities and ideologies, are associated with affective polarization. However, there is still a need to learn more about the consequences of different economic threats and identities fueling polarization. We take a longitudinal perspective in testing the influence of these phenomena on affective polarization. Specifically, we tested the effect of subjective personal and collective economic threats and political, national, regional, and European identities on affective polarization towards politicians and partisans in Spain. We use four waves of the E-DEM panel study from Spain (N = 2,501) collected between 2018 and 2019. We conducted longitudinal multilevel analyses to determine the growth in affective polarization and included predictors at the between- and within-person levels. Consistent with our hypotheses, we found that collective economic threats, such as perceiving more unfairness in the distribution of wealth and being dissatisfied with the Spanish economy, positively predict affective polarization. Contrary to our expectations, personal economic threats did not predict affective polarization. Furthermore, political and national identities positively predicted affective polarization towards politicians and partisans. Interestingly, exploratory analyses suggested that the associations between economic threats, identities, and affective polarization are moderated by political ideology. We discuss how economic threats and identities may exacerbate animosities toward political actors.
Arachidonic acid metabolism in human prostate cancer

The arachidonic acid pathway is important in the development and progression of numerous malignant diseases, including prostate cancer. To more fully evaluate the role of individual cyclooxygenases (COXs), lipoxygenases (LOXs) and their metabolites in prostate cancer, we measured mRNA and protein levels of COXs and LOXs and their arachidonate metabolites in androgen-dependent (LNCaP) and androgen-independent (PC-3 and DU145) prostate cancer cell lines, bone metastasis-derived MDA PCa 2a and MDA PCa 2b cell lines and their corresponding xenograft models, as well as core biopsy specimens of primary prostate cancer and nonneoplastic prostate tissue taken ex vivo after prostatectomy. Relatively high levels of COX-2 mRNA and its product PGE2 were observed only in PC-3 cells and their xenografts. By contrast, levels of the exogenous 12-LOX product 12-HETE were consistently higher in MDA PCa 2b and PC-3 cells and their corresponding xenograft tissues than were those in LNCaP cells. More strikingly, the mean endogenous level of 12-HETE was significantly higher in the primary prostate cancers than in the nonneoplastic prostate tissue (0.094 vs. 0.010 ng/mg protein, respectively; p=0.019). Our results suggest that LOX metabolites such as 12-HETE are critical in prostate cancer progression and that the LOX pathway may be a target for treating and preventing prostate cancer.
Time-domain thermal noise simulation of switched capacitor circuitsand delta-sigma modulators

This paper presents an accurate and efficient algorithm for simulating the effects of thermal noise in time-domain. The algorithm presented in this paper is based on Monte Carlo methods and is applicable to linear time invariant circuits. In addition to linear time invariant elements, the algorithm can easily be extended to include clock controlled switches and single or multibit quantizers. This expands the thermal noise analysis capability to switched capacitor circuits and oversampled delta-sigma modulators. Thermal noise generated by different elements is modeled, in the time-domain, by a random pulse waveform having a desired power spectral density. Typically the noise power level is much smaller than that of other desired signals in the circuit and accurate simulation is needed to obtain correct results. In addition, random noise waveforms require the computation of many time points in each transient analysis and efficient simulation methods are needed. In this paper, a new method for computing the transient response of linear time invariant circuits is used. This method accurately and efficiently computes the response to the random pulse waveforms. In addition to thermal noise, the method can also be used to simulate the effect of random dither signals in delta-sigma modulators. Examples of noise simulation are given and, when possible, comparison with measurements, previously published results, or analytical expressions is done.
Higher levels of central adiposity in healthy premenopausal women with family histories of premenopausal breast cancer

Research strongly suggests that lower overall adiposity and higher central adiposity are independent risk factors for premenopausal breast cancer in the general population. We aimed to test the possibility that these factors may contribute to familial risk of premenopausal breast cancer. A convenience sample of healthy women, ages 25–49, was recruited to yield three study groups: (1) Women with first‐degree family histories of premenopausal breast cancer, operationally defined as being diagnosed prior to age 50 (Group FH < 50, n = 39); (2) Women with first‐degree family histories of postmenopausal breast cancer, operationally defined as being diagnosed at age 50 or after (Group FH ≥ 50, n = 33); and (3) Women without a history of breast cancer in first‐degree relatives (Group FH−, n = 132). Multinomial logistic regression analyses, including possible confounders, waist circumference, and BMI, revealed a lower BMI among FH < 50 compared to either FH− (OR = 0.72; 95% CI = 0.59–0.87), or FH ≥ 50 women (OR = 0.75; 95% CI = 0.60–0.95), and higher waist circumferences in FH < 50 compared to either FH− (OR = 1.15; 95% CI = 1.06–1.25), or FH ≥ 50 women (OR = 1.16; 95% CI = 1.05–1.28). No group differences were seen for waist skinfold measures. These results support the possibility that differences in patterns of adiposity may contribute to familial risk of premenopausal breast cancer, and suggest the importance of conducting large scale, population‐based studies of the link between body size characteristics and familial breast cancer risk. Am. J. Hum. Biol., 2008. © 2007 Wiley‐Liss, Inc.
Loop series expansion with propagation diagrams

The Bethe approximation is a successful method for approximating partition functions of probabilistic models associated with a graph. Recently, Chertkov and Chernyak derived an interesting formula called ‘loop series expansion’, which is an expansion of the partition function. The main term of the series is the Bethe approximation while other terms are labelled by subgraphs called generalized loops. In this paper, we derive a loop series expansion of binary pairwise Markov random fields with ‘propagation diagrams’, which describes rules as to how ‘first messages’ and ‘secondary messages’ propagate. Our approach allows us to express the loop series in the form of a polynomial with coefficients positive integers. Using the propagation diagrams, we establish a new formula that shows a relation between the exact marginal probabilities and their Bethe approximations.
Optimal Control of Nonlinear Continuous-Time Systems in Strict-Feedback Form

This paper proposes a novel optimal tracking control scheme for nonlinear continuous-time systems in strict-feedback form with uncertain dynamics. The optimal tracking problem is transformed into an equivalent optimal regulation problem through a feedforward adaptive control input that is generated by modifying the standard backstepping technique. Subsequently, a neural network-based optimal control scheme is introduced to estimate the cost, or value function, over an infinite horizon for the resulting nonlinear continuous-time systems in affine form when the internal dynamics are unknown. The estimated cost function is then used to obtain the optimal feedback control input; therefore, the overall optimal control input for the nonlinear continuous-time system in strict-feedback form includes the feedforward plus the optimal feedback terms. It is shown that the estimated cost function minimizes the Hamilton-Jacobi-Bellman estimation error in a forward-in-time manner without using any value or policy iterations. Finally, optimal output feedback control is introduced through the design of a suitable observer. Lyapunov theory is utilized to show the overall stability of the proposed schemes without requiring an initial admissible controller. Simulation examples are provided to validate the theoretical results.
Low delay moving-horizon multiple-description audio coding forwireless hearing aids

In this work, we construct a novel scheme for efficient perceptual coding of audio for robust communication between encoders and wireless hearing aids. To limit the physical size of the hearing aids and to reduce power consumption and thereby increase the lifetime expectancy of the batteries, the hearing aids are constrained to be of low complexity. We therefore provide an asymmetric strategy where most of the computational load is placed at the encoding side. We make use of multiple-description coding. This combats possible erasures on the wireless link between the encoder and the hearing aids without introducing significant delay. Furthermore, we employ psychoacoustically optimized noise-shaping quantizers based on the moving-horizon principle, which exploits a finite prediction horizon.
The monoclonality of human B-cell lymphomas

Human tissues involved with lymphoma have been examined in frozen sections for immunoglobulin-bearing cells by a technique involving double-label immunofluorescence with mixed anti-kappa and anti-lambda antibodies. F (ab')2 fragments of purified antibodies were employed to avoid any binding via Fc receptors. B cell lymphomas were shown to be composed of monoclonal populations of Ig bearing cells, whereas normal or reactive lymphoid follicles contained a mosaic of Ig-bearing cells derived from multiple clones. Nodules of lymphoma were often surrounded by normal polyclonal B cell populations. We anticipates that the approach described here will be useful in the diagnosis of lymphoma, differentiating it from reactive lymphoid hyperplasia by the demostration of monoclonality. In addition, it should provide a sensitive and reliable tool for investigating the immunobiology of human lymphoma.
Working Paper No . 615 , 2004 Equilibrium Search Unemployment with Explicit Spatial Frictions

Assuming that job search efficiency decreases with distance to jobs, workers’ location in a city depends on spatial elements such as commuting costs and land prices and on labour elements such as wages and the matching technology. In the absence of moving costs, we show that there exists a unique equilibrium in which employed and unemployed workers are perfectly segregated but move at each employment transition. We investigate the interactions between the land and the labour market equilibrium and show under which condition they are interdependent. When relocation costs become positive, a new zone appears in which both the employed and the unemployed co-exist and are not mobile. We demonstrate that the size of this area goes continuously to zero when moving costs vanish. Finally, we endogeneize search effort, show that it negatively depends on distance to jobs and that long and short-term unemployed workers coexist and locate in different areas of the city. J.E. L. Classification: E24, J41, R14
Extremes of weight gain and weight loss with detailed assessments of energy balance: Illustrative case studies and clinical recommendations

Abstract Extreme weight changes, or changes in weight greater than 10 kg within a 2-year period, can be caused by numerous factors that are much different than typical weight fluctuations. This paper uses two interesting cases of extreme weight change (a female who experienced extreme weight gain and a male who experienced extreme weight loss) from participants in the Energy Balance Study to illustrate the physiological and psychosocial variables associated with the weight change over a 15-month period, including rigorous assessments of energy intake, physical activity (PA) and energy expenditure, and body composition. In addition, we provide a brief review of the literature regarding the relationship between energy balance (EB) and weight change, as well as insight into proper weight management strategies. The case studies presented here are then placed in the context of the literature regarding EB and weight change. This report further supports previous research on the importance of regular doses of PA for weight maintenance, and that even higher volumes of PA are necessary for weight loss. Practitioners should emphasize the importance of PA to their patients and take steps to monitor their patients’ involvement in PA.
Voltage and Current Spectra for Matrix Power Converters

Matrix power converters are used for transforming one alternating-current power supply to another, with different peak voltage and frequency. There are three input lines, with sinusoidally varying voltages which are $120^\circ$ out of phase one from another, and the output is to be delivered as a similar three-phase supply. The matrix converter switches rapidly, to connect each output line in sequence to each of the input lines in an attempt to synthesize the prescribed output voltages. The switching is carried out at high frequency and it is of practical importance to know the frequency spectra of the output voltages and of the input and output currents. We determine in this paper these spectra using a new method, which has significant advantages over the prior default method (a multiple Fourier series technique), leading to a considerably more direct calculation. In particular, the determination of the input current spectrum is feasible here, whereas it would be a significantly more daunting procedure u.
Simple mechanisms organise orientation of escape swimming in embryos and hatchling tadpoles of Xenopus laevis.

Many amphibian tadpoles hatch and swim before their inner ears and sense of spatial orientation differentiate. We describe upward and downward swimming responses in hatchling Xenopus laevis tadpoles from stages 32 to 37/38 in which the body rotates about its longitudinal axis. Tadpoles are heavier than water and, if touched while lying on the substratum, they reliably swim upwards, often in a tight spiral. This response has been observed using stroboscopic photography and high-speed video recordings. The sense of the spiral is not fixed for individual tadpoles. In 'more horizontal swimming' (i.e. in directions within +/-30 degrees of the horizontal), the tadpoles usually swim belly-down, but this position is not a prerequisite for subsequent upward spiral swimming. Newly hatched tadpoles spend 99 % of their time hanging tail-down from mucus secreted by a cement gland on the head. When suspended in mid-water by a mucus strand, tadpoles from stage 31 to 37/38 tend to swim spirally down when touched on the head and up when touched on the tail. The three-dimensional swimming paths of stage 33/34 tadpoles were plotted using simultaneous video images recorded from the side and from above. Tadpoles spiralled for 70 % of the swimming time, and the probability of spiralling increased to 1 as swim path angles became more vertical. Tadpoles were neutrally buoyant in Percoll/water mixtures at 1.05 g cm(-)(3), in which anaesthetised tadpoles floated belly-down and head-up at 30 degrees. In water, their centre of mass was ventral to the muscles in the yolk mass. A simple mathematical model suggests that the orientation of tadpoles during swimming is governed by the action of two torques, one of which raises the head (i.e. increases the pitch) and the other rotates (rolls) the body. Consequently, tadpoles (i) swim belly-down when the body is approximately horizontal because the body is ballasted by dense yolk, and (ii) swim spirally at more vertical orientations when the ballasting no longer stabilises orientation. Measurements in tethered tadpoles show that dorsal body flexion, which could produce a dorsal pitch torque, is present during swimming and increases with tailbeat frequency. We discuss how much of the tadpole's behaviour can be explained by our mathematical model and suggest that, at this stage of development, oriented swimming responses may depend on simple touch reflexes, the organisation of the muscles and physical features of the body, rather than on vestibular reflexes.
The Impact of Dynamic Voltage and Frequency Scaling on Multicore DSP Algorithm Design [Exploratory DSP]

We connect to the two recent IEEE Signal Processing Magazine special issues on digital signal processing (DSP) on multicore processors (November 2009 and March 2010) and address an issue that was not addressed in the articles there, which we believe has important consequences for DSP algorithm design in the future. The basic observation that we start out with is that in DSP algorithm design, there is very often a tradeoff between the computational effort spent (in terms of the number of operations) and the quality/accuracy of the algorithm output. Herein we discuss the problems that emerge when optimizing algorithms for circuits that support the operation of several parallel cores that operate at different speeds. The understanding, formulation, and solution of these optimization problems require a cross-disciplinary approach that models the interplay between circuits, computer architecture, signal processing, and optimization. While allocation of computational and transmission resources for the purpose of saving energy is an established research topic in other fields (sensor network life time maximization being a notable example), there appears to be relatively little open literature on the type of problems that we discuss here. Taken together, we believe that the challenges we pose are important and that the signal processing algorithm design community is well positioned to tackle them.
Distinct Effects of Inorganic Phosphate on Cell Cycle and Apoptosis in Human Vascular Smooth Muscle Cells

Inorganic phosphate (Pi) is an essential nutrient to all living organisms. Nevertheless, hyperphosphatemia is now recognized as a risk factor for cardiovascular events and mortality in chronic kidney disease (CKD) patients. To our knowledge, the mechanisms by which elevated Pi alters smooth muscle cell proliferation have been poorly addressed. Therefore, in this study, we investigated the effects of Pi on cell cycle regulation and apoptosis in human aortic smooth muscle cells (HAoSMC). HAoSMC were treated with physiologic (1 mM) or high (2 and 3 mM) Pi concentrations. We showed that Pi not only decreased significantly cell viability (P < 0.001) but also induced apoptosis of HAoSMC. Moreover, Pi treatment blocked G1/S cell cycle progression by increasing cell number in G0/G1 phase up to 82.4 ± 3.4% for 3 mM vs 76.2 ± 3.1% for control (P < 0.01) while decreasing cell number in S phase. Accordingly, this was associated with a decrease protein expression of cyclin E and its associated CDK (CDK2), and phosphorylated retinoblastoma protein. Moreover, we observed an increase of protein expression of cell cycle inhibitors p15, p21, and p27. Interestingly, we also found that induction of cell cycle arrest was partially dependent on phosphate uptake. Our results demonstrated that Pi reduced HAoSMC proliferation by inducing apoptosis and cell cycle arrest. Indeed, we showed for the first time that Pi affected HAoSMC cell cycle by blocking G1/S progression. These findings would be useful for a better understanding of molecular mechanisms involved in vascular complications observed in CKD patients. J. Cell. Physiol. 230: 347–355, 2015. © 2014 Wiley Periodicals, Inc.
A review of the use of somatostatin analogs in oncology

Somatostatin is a neuropeptide produced by paracrine cells that are located throughout the gastrointestinal tract, lung, and pancreas, and is also found in various locations of the nervous system. It exerts neural control over many physiological functions including inhibition of gastrointestinal endocrine secretion through its receptors. Potent and biologically stable analogs of somatostatin have been developed. These somatostatin analogs show different efficacy on different receptors, and receptors are varyingly concentrated in specific tissues. Antitumor and antisecretory effects of somatostatin analogs in cancer have been shown in several in vivo and in vitro studies. However, these activities have not always yielded into clinically relevant patient outcome benefit. Somatostatin analogs are of clinical benefit in treating symptoms of ectopic hormone secretion (adrenocorticotropic hormone, growth hormone-releasing hormone) in lung cancer, without inducing a significant tumor response. They have also been shown to induce a statistically significant decrease in bone pain and increase in Karnofsky performance status in patients with metastatic prostate cancer. Somatostatin analogs alone or in combination with other agents have only limited antitumoral effect in breast cancer. In gastrointestinal cancers, studies have not shown an objective tumor response to somatostatin analogs except in endocrine tumors of the liver with symptomatic and biochemical improvement. In neuroendocrine tumors of the gastrointestinal system and pancreas, very high symptomatic and biochemical response rates have been achieved with somatostatin analogs. Antiproliferative activity has been clearly shown in metastatic midgut neuroendocrine tumors.