Miracle-dz/UniFAR-FTUs huggingface dataset:
A CAPACITY-BUILDING FRAMEWORK: A SEARCH FOR CONCEPT AND PURPOSE

A growing number of persons (capacity builders) purport to be doing something they call "capacity building. " They go about this activity in a variety of ways-demonstrations, grants, consulting, training and development, and circuit riding, to name a few. Capacity building tends to address specialized management issues-financial management, organization development, grantsmanship, and service integration, for instance-usually depending upon the purview and interests of the capacity builders. These characteristics of capacity building are not necessarily bad. Attempts to address the broad gamut of management issues may be overly ambitious and do the client a disservice. Bolstering management practices in specific areas can build support for extending administrative improvements to others. Further, by making changes incrementally, useful knowledge is gained for application to future innovations. Hence, it may be wise to focus attention on selected management problems. In too many cases, however, capacity building is conceived of as the application of a particular approach to every management problem in any context. Or it is considered as the improvement of a facet of management which is equated with organizational capacity. An urgent need exists for a concept and purpose in capacity building. This need is underscored by the recent budget-cutting climate, which means that governments will have to operate more efficiently and effectively with fewer resources. Further, with the Reagan administration's proposals to consolidate several categorical grant programs into block grants administered by the states, many of those affected-particularly mayors and interest groups that benefited from categoricals-have raised questions concerning the capacities of various states to take on new responsibilities. Since the administration's long-range plans also call for "revenue turnbacks," the states' fiscal and management capacities are both timely issues.
High‐throughput automated refolding screening of inclusion bodies

One of the main stumbling blocks encountered when attempting to express foreign proteins in Escherichia coli is the occurrence of amorphous aggregates of misfolded proteins, called inclusion bodies (IB). Developing efficient protein native structure recovery procedures based on IB refolding is therefore an important challenge. Unfortunately, there is no “universal” refolding buffer: Experience shows that refolding buffer composition varies from one protein to another. In addition, the methods developed so far for finding a suitable refolding buffer suffer from a number of weaknesses. These include the small number of refolding formulations, which often leads to negative results, solubility assays incompatible with high‐throughput, and experiment formatting not suitable for automation. To overcome these problems, it was proposed in the present study to address some of these limitations. This resulted in the first completely automated IB refolding screening procedure to be developed using a 96‐well format. The 96 refolding buffers were obtained using a fractional factorial approach. The screening procedure is potentially applicable to any nonmembrane protein, and was validated with 24 proteins in the framework of two Structural Genomics projects. The tests used for this purpose included the use of quality control methods such as circular dichroism, dynamic light scattering, and crystallogenesis. Out of the 24 proteins, 17 remained soluble in at least one of the 96 refolding buffers, 15 passed large‐scale purification tests, and five gave crystals.
RELATIONSHIP BETWEEN SELECTED ANTHROPOMETRIC MEANSURES OF LOWER LIMBS AND ANAEROBIC POWER IN UNIVERSITY STUDENTS

Anaerobic power is an important element in many sports but it is difficult to find out with simple apparatus. This study aimed to investigate the relationship between the selected anthropometric measures of limb lower and anaerobic power in university students. Thirty-one female subjects (n=31) from the Hong Kong Baptist University who aged between 18 and 26 participated in the study. (Age: 21.45±1.95 years; Height: 160.39±5.51 (cm); Weight: 54.42±6.12 (kg); %body fat: 25.02%±3.57%)The study included a anthropometric measurement of five sites in the lower limbs (Thigh length; Calf length; Mid-thigh circumference; Calf circumference; Ankle circumference ) and the Wingate Anaerobic Test. No significant relationships were found between all the selected anthropometric measures and anaerobic power using Pearson correlation analysis (P>0.05). The result suggested that there were only small correlation between the selected anthropometric measures and the anaerobic power.
Methicillin-Resistant Staphylococcus aureus: A 5-Year Review of Surveillance Data in a Tertiary Care Hospital in Saudi Arabia

Background. Staphylococcus aureus is an important pathogen that leads to serious infections in the community and in hospitals. Evidence has shown that the prevalence of infection and colonization with drug-resistant S. aureus, such as methicillin-resistant S. aureus (MRSA) and glycopeptide intermediately susceptible S. aureus, is increasing. Authorities must be aware of the prevalence of MRSA infection and colonization in their country in order to implement and monitor infection control policies that help curtail further emergence of this pathogen. Objectives. To examine the trend of hospital-acquired MRSA infection and colonization in a tertiary care institution in Saudi Arabia during a 5-year period in order to identify specific areas at high risk for MRSA transmission, and to review our MRSA decolonization procedure and outcomes. Methods. Surveillance data prospectively collected from January 1, 2000, through December 31, 2004, on hospital-acquired (HA) MRSA were analyzed, with an emphasis on the trend of HA-MRSA infection and colonization, areas of high transmission, risk factors, and effectiveness of the implemented decolonization policy. Results. During the study period, 442 cases of HA-MRSA infection and colonization were identified. Of these, 51.2% were infections, and 48.8% were colonizations. An increasing trend in the incidence rates of infection and colonization was noticed during the study period, and most cases were identified on the surgical ward (33.3%) and medical ward (32.1%). Of the 34 infected patients who underwent systematic decolonization, 35.3% were successfully decolonized, and of the 11 who underwent topical decolonization, 63.6% were successfully decolonized. Conclusion. The increasing trend of HA-MRSA infections has been a noticeable global problem. We identified a gradual increase in the rates of MRSA colonization and infection in a tertiary care center Saudi Arabia and recognize the importance of abiding by strict infection control policies, including hand hygiene and proper isolation practices. Continued surveillance for MRSA and other emerging multidrug-resistant pathogens is also needed.
Bisphosphonates for treatment of osteoporosis: expected benefits, potential harms, and drug holidays.

OBJECTIVE To outline the efficacy and risks of bisphosphonate therapy for the management of osteoporosis and describe which patients might be eligible for bisphosphonate "drug holiday. " QUALITY OF EVIDENCE MEDLINE (PubMed, through December 31, 2012) was used to identify relevant publications for inclusion. Most of the evidence cited is level II evidence (non-randomized, cohort, and other comparisons trials). MAIN MESSAGE The antifracture efficacy of approved first-line bisphosphonates has been proven in randomized controlled clinical trials. However, with more extensive and prolonged clinical use of bisphosphonates, associations have been reported between their administration and the occurrence of rare, but serious, adverse events. Osteonecrosis of the jaw and atypical subtrochanteric and diaphyseal femur fractures might be related to the use of bisphosphonates in osteoporosis, but they are exceedingly rare and they often occur with other comorbidities or concomitant medication use. Drug holidays should only be considered in low-risk patients and in select patients at moderate risk of fracture after 3 to 5 years of therapy. CONCLUSION When bisphosphonates are prescribed to patients at high risk of fracture, their antifracture benefits considerably outweigh their potential for harm. For patients taking bisphosphonates for 3 to 5 years, reassess the need for ongoing therapy.
Do Family Responsibilities and a Clinical Versus Research Faculty Position Affect Satisfaction with Career and Work-Life Balance for Medical School Faculty?

BACKGROUND Balancing career and family obligations poses challenges to medical school faculty and contributes to dissatisfaction and attrition from academics. We examined the relationship between family setting and responsibilities, rank, and career and work-life satisfaction for faculty in a large U.S. medical school. METHODS Baseline faculty surveys were analyzed from the first year of a 4-year National Institutes of Health-funded study to evaluate awareness, knowledge, attitudes, and use of family friendly policies and career satisfaction. The study focus was on the impact of family responsibilities and characteristics of the faculty position (rank, clinical vs. nonclinical, and academic series) in multivariate comparisons between primary predictors and outcomes of interest. RESULTS Both clinical and family responsibilities for children under 18 play a major and interacting role in satisfaction with career and work-life balance. Clinical faculty respondents without children at home reported significantly greater career satisfaction and better work-life balance than their nonclinical counterparts. Nonclinical faculty respondents with children reported greater satisfaction and better balance than counterparts without family responsibilities. However, the advantage in career satisfaction and work-life balance for clinical faculty respondents disappeared for those with responsibility for young children. No gender-based differences were noted in the results or across faculty rank for respondents; however, for women, reaching associate professor resulted in greater career satisfaction. CONCLUSION This study suggests that both work-related factors and family responsibilities influence satisfaction with career and work-life balance, but the predictors appear to interact in complex and nuanced ways. Further research is needed to delineate more clearly these interactions and to explore other factors that may play important additional roles.
Ethical decision-making based on field assessment: The experiences of prehospital personnel

Introduction: Due to the stressful nature of prehospital emergency providers’ duties, as well as difficulties such as distance to information resources and insufficient time to analyze situations, ethical decision-making in prehospital services is a daily challenge. Objectives: This study aimed to describe the experiences of Iranian prehospital emergency personnel in the field of ethical decision-making. Methods: The data were collected by semi-structured interviews (n = 15) in Iran and analyzed using the content analysis approach. Ethical considerations: This study was conducted in accordance with the principles of research ethics and national rules and regulations relating to informed consent and confidentiality. Results: The results obtained were categorized into three main categories that included “assessment of the scene atmosphere, assessment of patients’ condition and their family, and predicting outcomes of decision-making. ” The central category was “field assessment,” which demonstrated the strategy of ethical decision-making by prehospital providers when facing ethical conflicts. Conclusion: Although findings showed that the majority of prehospital providers make ethical decisions based on the patients’ benefit, they also consider consequences of their decisions in dealing with personal and professional threats. This article identifies and describes a number of ethical values of prehospital providers and discusses how the values may be considered by paramedics when facing ethical conflicts.
High-Speed MEMS-Based Gas Chromatography

This paper reports microfabricated silicon-glass separation columns for high-speed micro gas chromatography (muGC) systems. The microfabricated columns are integrated with resistive heaters and temperatures sensors and capacitive pressure sensors to allow temperature and pressure programming and flow control and to achieve reproducible separations in a muGC system. These 25-cm-long, 150-mum-wide, and 250-mum-deep columns are fabricated on a 1.2-cm square die using a silicon-on-glass dissolved wafer process. Programmed with temperature ramps of 10 degC/s, the low-mass columns separate eleven-component gaseous mixtures in less than 10 s, including alkanes from C5 to C16 and simulants for C-4, TNT, sarin, and mustard gas. When used in arrayed architectures, these MEMS columns should allow high-speed analysis without sacrificing separation efficiency
N-benzylimidazole-mediated changes in hepatic drug-metabolizing enzyme activities in Ah-responsive and Ah-non-responsive mice.

1. The inductive effect of N-benzylimidazole (NBI) on hepatic microsomal and cytosolic drug-metabolizing enzyme activities in aryl hydrocarbon (Ah)-responsive C57BL/6N (B6) and Ah-non-responsive DBA/2N (D2) mouse strains was determined and compared with that caused by beta-naphthoflavone (BNF). 2. Relative Ah-responsiveness of the two strains was confirmed by measurement of BNF-induced ethoxyresorufin deethylase (EROD) activity and ELISA immunoquantification. BNF markedly induced EROD activity only in the Ah-responsive B6 mouse strain (65-fold increase). 3. NBI (150 mg/kg per day for 3 days) increased cytochrome P450 concentration similarly in both strains (40 and 60% in B6 and D2 strains, respectively). Compared with BNF treatment of the B6 strain, increases in EROD activity following NBI treatment were only minor. In addition, EROD activity increases were greater in the Ah-nonresponsive D2 strain (300%) than in the Ah-responsive B6 strain (100%) suggesting the possibility of an induction mechanism different from that of recognized Ah receptor agonists. 4. Induction of UDP-glucuronosyltransferase activity (p-nitrophenol acceptor) by BNF was greater in the Ah-responsive B6 strain than in the Ah-non-responsive D2 strain. NBI failed to induce this activity in either strain. 5. Induction of glutathione S-transferase activity towards 1-chloro-2,4-dinitrobenzene following NBI treatment occurred to the same extent (25% increase) as that seen following BNF treatment, in the Ah-responsive B6 strain. Neither xenobiotic affected this activity in the Ah-non-responsive D2 strain. 6. Although NBI is a major inducer, possessing Ah-like inducing properties in rat, it caused only minor changes in murine drug metabolizing enzymes. (ABSTRACT TRUNCATED AT 250 WORDS)
TITLE : Real-Time Tracking of Implanted Markers During Radiation Treatment by Use of Simultaneous kV and MV Imaging PRINCIPAL INVESTIGATOR :

The integration of onboard kV imaging together with a MV electronic portal imaging device (EPID) on linear accelerators (LINAC) can provide an easy to implement real-time 3D organ position monitoring solution for treatment delivery. Currently, real-time MV–kV tracking has only been demonstrated by simultaneous imagining by both MV and kV imaging devices. However, modalities such as step-and-shoot IMRT (SS-IMRT), which inherently contain MV beam interruptions, can lead to loss of target information necessary for 3D localization. Additionally, continuous kV imaging throughout the treatment delivery can lead to high levels of imaging dose to the patient. This work demonstrates for the first time how full 3D target tracking can be maintained even in the presence of such beam interruption, or MV/kV beam interleave, by use of a relatively simple correlation model together with MV–kV tracking. A moving correlation model was constructed using both present and prior positions of the marker in the available MV or kV image to compute the position of the marker on the interrupted imager. A commercially available radiotherapy system, equipped with both MV and kV imaging devices, was used to deliver typical SS-IMRT lung treatment plans to a 4D phantom containing internally embedded metallic markers. To simulate actual lung tumor motion, previous recorded 4D lung patient motion data were used. Lung tumor motion data of five separate patients were inputted into the 4D phantom, and typical SS-IMRT lung plans were delivered to simulate actual clinical deliveries. Application of the correlation model to SS-IMRT lung treatment deliveries was found to be an effective solution for maintaining continuous 3D tracking during ‘step’ beam interruptions. For deliveries involving five or more gantry angles with 50 or more fields per plan, the positional errors were found to have 1 mm root mean squared error (RMSE) in all three spatial directions. In addition to increasing the robustness of MV–kV tracking against beam interruption, it was also found that use of correlation can be an effective way of lowering kV dose 0031-9155/09/010089+15$30.00 © 2009 Institute of Physics and Engineering in Medicine Printed in the UK 89 90 R D Wiersma et al to the patient and for increasing kV image quality by reduction of MV scatter interference. (Some figures in this article are in colour only in the electronic version)
Difference limens for phase in normal and hearing-impaired subjects.

These experiments measure the ability to detect a change in the relative phase of a single component in a harmonic complex tone. Complex tones containing the first 20 harmonics of 50, 100, or 200 Hz, all at equal amplitude, were used. All of the harmonics except one started in cosine phase. The remaining harmonic started in cosine phase, but was shifted in phase half-way through either the first or the second of the two stimuli comprising a trial. The subject had to identify the stimulus containing the phase-shifted component. For normally hearing subjects tested at a level of 70 dB SPL per component, thresholds for detecting the phase shift [i.e., phase difference limens (DLs)] were smallest (2 degrees-4 degrees) for harmonics above the eighth and for the lowest fundamental frequency (F0). Changes in phase were not detectable for harmonic numbers below three or four at the lowest F0 and below 5-13 at the highest F0. The DLs increased slightly for the highest harmonics in the complexes. The DLs increased markedly with decreasing level, except for the highest harmonic, where only a small effect of level was found. Subjects reported that the phase-shifted harmonic appeared to "pop out" and was heard with a pure-tone quality. A pitch-matching experiment demonstrated that the pitch of this tone corresponded to the frequency of the phase-shifted component. For the highest harmonic, the phase shift was associated with a downward shift of the edge pitch heard in the reference (all cosine phase) stimulus. When the phases of the components in the reference stimulus were randomized, phase DLs were much higher (and often impossible to measure), the pop-out phenomenon was not observed, and no edge pitch was heard. Subjects with unilateral cochlear hearing impairment generally showed poorer phase sensitivity in their impaired than in their normal ears, when the two ears were compared at equal sound-pressure levels. However, at comparable sensation levels, the impaired ears sometimes showed lower phase DLs. The results are explained by considering the waveforms that would occur at the outputs of the auditory filters in response to these stimuli.
The Impact of Firm Risk on Property-Liability Insurance Prices

This article examines the impact of an insurer's level of insolvency risk on the prices the insurer obtains for its products in the property-liability insurance market. The measures of insolvency risk used are those implied by the option pricing model of insurance. The key finding is the existence of a negative relation between insolvency risk and insurance prices. This implies that property-liability insurers are penalized for default risk through lower prices, despite the existence of guaranty funds. Other firm-specific determinants of insurance prices are also identified. The results have significant implications for insurance researchers and regulators.
Phytoplankton, not allochthonous carbon, sustains herbivorous zooplankton production

Terrestrial organic matter inputs have long been thought to play an important role in aquatic food web dynamics. Results from recent whole lake 13C addition experiments suggest terrestrial particulate organic carbon (t-POC) inputs account for a disproportionate portion of zooplankton production. For example, several studies concluded that although t-POC only represented ≈20% of the flux of particulate carbon available to herbivorous zooplankton, this food source accounted for ≈50% of the C incorporated by zooplankton. We tested the direct dietary impact of t-POC (from the leaves of riparian vegetation) and various phytoplankton on Daphnia magna somatic growth, reproduction, growth efficiency, and lipid composition. By itself, t-POC was a very poor quality resource compared to cryptophytes, diatoms, and chlorophytes, but t-POC had similar food quality compared to cyanobacteria. Small additions of high quality Cryptomonas ozolinii to t-POC-dominated diets greatly increased Daphnia growth and reproduction. When offered alone, t-POC resulted in a Daphnia growth efficiency of 5 ± 1%, whereas 100% Cryptomonas and Scenedesmus obliquus diets resulted in growth efficiencies of 46 ± 8% (± SD) and 36 ± 3%, respectively. When offered in a 50:50 mixed diet with Cryptomonas or Scenedesmus, the t-POC fraction resulted in a partial growth efficiency of 22 ± 9% and 15 ± 6%, respectively. Daphnia that obtained 80% of their available food from t-POC assimilated 84% of their fatty acids from the phytoplankton component of their diet. Overall, our results suggest Daphnia selectively allocate phytoplankton-derived POC and lipids to enhance somatic growth and reproduction, while t-POC makes a minor contribution to zooplankton production.
Effects of Psychological Need Satisfaction on Proactive Work Behaviors

The present study examined the drivers of proactive behavior in a workplace. Amazon Mechanical Turk workers (N = 218), currently employed in the US for either a full-time or part-time position, completed a questionnaire measuring four different types of proactive work behaviors, three basic psychological needs, task interdependence, task significance, and employee engagement. The most important predictor in the study was the satisfaction of the basic psychological needs: autonomy, competence, and relatedness. Participants who scored high on psychological need satisfaction were more likely to perform proactive work behaviors than those who scored low. Also, psychological need satisfaction moderated the relationship between task significance and proactive work behaviors, such that those who scored low on psychological need satisfaction tended to perform proactive work behaviors only when they perceived their job to have meaningful impacts on their surroundings. Employee engagement partially mediated the relationship between psychological need satisfaction and proactive work behaviors. The limitations of the present study and future directions are discussed.