Miracle-dz/UniFAR-FTUs huggingface dataset:
Timing of recanalization after tissue plasminogen activator therapy determined by transcranial doppler correlates with clinical recovery from ischemic stroke.

BACKGROUND The duration of cerebral blood flow impairment correlates with irreversibility of brain damage in animal models of cerebral ischemia. Our aim was to correlate clinical recovery from stroke with the timing of arterial recanalization after therapy with intravenous tissue plasminogen activator (tPA). METHODS Patients with symptoms of cerebral ischemia were treated with 0.9 mg/kg tPA IV within 3 hours after stroke onset (standard protocol) or with 0.6 mg/kg at 3 to 6 hours (an experimental institutional review board-approved protocol). National Institutes of Health Stroke Scale (NIHSS) scores were obtained before treatment, at the end of tPA infusion, and at 24 hours; Rankin Scores were obtained at long-term follow-up. Transcranial Doppler (TCD) was used to locate arterial occlusion before tPA and to monitor recanalization (Marc head frame, Spencer Technologies; Multigon 500M, DWL MultiDop-T). Recanalization on TCD was determined according to previously developed criteria. RESULTS Forty patients were studied (age 70+/-16 years, baseline NIHSS score 18.6+/-6.2). A tPA bolus was administered at 132+/-54 minutes from symptom onset. Recanalization on TCD was found at the mean time of 251+/-171 minutes after stroke onset: complete recanalization occurred in 12 (30%) patients and partial recanalization occurred in 16 (40%) patients (maximum observation time 360 minutes). Recanalization occurred within 60 minutes of tPA bolus in 75% of patients who recanalized. The timing of recanalization inversely correlated with early improvement in the NIHSS scores within the next hour (polynomial curve, third order r(2)=0.429, P<0.01) as well as at 24 hours. Complete recanalization was common in patients who had follow-up Rankin Scores if 0 to 1 (P=0.006). No patients had early complete recovery if an occlusion persisted for >300 minutes. CONCLUSIONS The timing of arterial recanalization after tPA therapy as determined with TCD correlates with clinical recovery from stroke and demonstrates a 300-minute window to achieve early complete recovery. These data parallel findings in animal models of cerebral ischemia and confirm the relevance of these models in the prediction of response to reperfusion therapy.
Evidence of an epithelial stem/progenitor cell hierarchy in the adult mouse lung

The role of lung epithelial stem cells in maintenance and repair of the adult lung is ill-defined, and their identity remains contentious because of the lack of definitive markers for their prospective isolation and the absence of clonogenic assays able to measure their stem/progenitor cell potential. In this study, we show that replication of epithelial–mesenchymal interactions in a previously undescribed matrigel-based clonogenic assay enables the identification of lung epithelial stem/progenitor cells by their colony-forming potential in vitro. We describe a population of EpCAMhi CD49fpos CD104pos CD24low epithelial cfus that generate colonies comprising airway, alveolar, or mixed lung epithelial cell lineages when cocultured with EpCAMneg Sca-1pos lung mesenchymal cells. We show that soluble fibroblast growth factor-10 and hepatocyte growth factor partially replace the requirement for mesenchymal support of epithelial colony formation, allowing clonal passaging and demonstration of their capacity for self-renewal. These data support a model in which the adult mouse lung contains a minor population of multipotent epithelial stem/progenitor cells with the capacity for self-renewal and whose descendants give rise to airway and alveolar epithelial cell lineages in vitro.
Less than the sum? What is missing in UK mass HE?

Roger Brown, the Chair of the Editorial Advisory Board, and I are delighted that John Aubrey Douglass, Senior Research Fellow of the Center for Studies in Higher Education at the University of California Berkeley, has agreed to edit this special issue of perspectives. The papers arise out of contributions to a Symposium in September 2004 on UK and US Higher Education Funding and Access, organised by the Oxford Centre for Higher Education Policy Studies (OxCHEPS) and the Center for Studies in Higher Education at the University of California Berkeley campus. It was co‐chaired by John and David Palfreyman, the Director of OxCHEPS, and it is a pleasure and privilege to publish some of the main papers. We are indebted to the AUA, the Sutton Trust, the Higher Education Policy Institute, the Rothermere Institute, the Institute for Governmental Studies (UC Berkeley), the Center for British Studies (UC Berkeley), and the University of California Office of the President, all of whom provided support for the Symposium. John’s first paper sets the scene on the UK funding environment and student support, and provides a context for those that follow. Ed.
Maternal complications and procedures in pregnancy and at birth and wheezing phenotypes in children.

RATIONALE There is increasing interest in the potential influence of fetal and early life conditions on childhood wheezing. OBJECTIVES To investigate the associations between maternal complications and procedures in pregnancy and at birth and the risk of various wheezing phenotypes in young children. METHODS We studied 15,609 children, aged 6-7 yr, enrolled in a population-based study. Standardized questionnaires were completed by the children's mothers. RESULTS Of the children, 9.5% (1,478) had transient early wheezing, 5.4% (884) had persistent wheezing, and 6.1% (948) had late-onset wheezing. Maternal hypertension or preeclampsia was associated with an increased risk of all three wheezing phenotypes (for transient early wheezing: odds ratio [OR], 1.40; 95% confidence interval [95% CI], 1.08-1.82; for persistent wheezing: OR, 1.59; 95% CI, 1.15-2.19; and for late-onset wheezing: OR, 1.47; 95% CI, 1.06-2.01). Use of antibiotics for urinary tract infections was associated with transient early wheezing (OR, 1.52; 95% CI, 1.16-2.00), whereas antibiotic administration at delivery was associated with both transient early wheezing (OR, 1.21; 95% CI, 1.01-1.46) and persistent wheezing (OR, 1.39; 95% CI, 1.10-1.75). Children who had a mother with diabetes were also more likely to have persistent wheezing (OR, 1.72; 95% CI, 0.99-3.00). Neither amniocentesis/chorionic villus sampling, nor weight gain in pregnancy, nor cesarean section was associated with the subsequent development of wheezing. Maternal asthma or atopy was not an effect modifier of the associations found. CONCLUSIONS Some maternal complications during pregnancy and at delivery may increase the risk of developing different phenotypes of wheezing in childhood.
Myristate, a 14-Carbon Fatty Acid, Effectively Reverses Anesthesia

THE pressure reversal of anesthesia was discovered in the light intensity of bacterial luciferase. 1 This in vitro study implies that the partial molar volume of the luciferase is greater during anesthesia than during the awake state. 1 This observation was confirmed in vivo in tadpoles, 2 newts, 3 and rats. 4 We found that the light intensity of firefly luciferase (FFL) also responds to high pressure. 5 We also measured the effects of anesthetics and myristate (a 14-carbon fatty acid, neutralized by NaOH) on the volume of FFL. 6 Halothane 0.5 mM increased the FFL volume by 3.93 cm 3 mol -1 whereas myristate 2.5 μM decreased it by 7.66 cm 3 mol -1 . We hypothesized that if the molar volume of FFL determines depth of anesthesia, myristate may antagonize anesthesia. As expected, our preliminary study showed that myristate antagonized anesthesia in goldfish. 7 Contrary to the general belief that fatty acids are toxic to mammals, the intravenous hyperalimentation fluids, Intralipid (Baxter, Deerfield, IL), and others are composed of a variety of long-chain fatty acids: linoleic, oleic, palmitic, linolenic, stearic acids, and so on. These fatty acids are neutralized by triglycerides. They are called essential fatty acids (EFA), and are well tolerated by debilitated patients. The generally held idea among anesthesiologists that fatty acids do not cross the blood-brain barrier is contradicted by oleamide (18-carbon fatty acid, oleic acid, neutralized by NH 4 OH) which crosses the blood-brain barrier and induces sleep. 8,9 .
Misanthropy and attitudes toward international affairs

is to be asserted in general of men," he stated, "that they are ungrateful, fickle, false, cowardly, covetous. Love is preserved by the link of obligation which, owing to the baseness of man, is broken at every opportunity for their advantage . " (7, pp. 130-31). It is not surprising to learn that he considered "no effective government . possible except absolute monarchy" (10, p. 343). On the other hand, Kropotkin's belief in an anarchistic society was based essentially upon his assumption that most men were co-operative, helpful, and unselfish. "There is the gist of human psychology," he said. "Unless men are maddened in the battle-
Newspaper Reporters’ Priorities and Beliefs About Environmental Journalism: An Application of Q-Methodology

This article assesses the variety of discourses articulated by journalists reporting on environmental issues. In particular, it investigates how environmental journalists perceive their role and function as reporters of environmental issues as well as the problems they face while reporting. The authors interviewed 23 newspaper reporters covering environmental issues for the nine largest (in terms of daily circulation) daily Greek newspapers, by employing Q-methodology, a qualitative statistical approach specially adjusted for small samples. The subsequent analysis reveals three “factors,” or distinct discourses, labeled “scientifically objective, environmentally responsible journalist,” “environmental crusaders,” and “objective-pure journalists. ” By analyzing factors’ discourses, the authors concluded that these groups are highly similar to the “disseminator,” “interpreter/investigator,” and “populist mobilize” categories identified in previous research for journalists with different field orientations. However, the last category (“adversarial”) did not appear in our sample. The authors encourage the replication of this research study in other countries as an effective method of obtaining a broader understanding of the practices and impacts of environmental journalism at a global level.
Comparison of deconvolution techniques using a distribution mixture parameter estimation: Application in single photon emission computed tomography imagery

Thanks to its ability to yield functionally rather than anatomically-based information, the single photon emission computed tomography (SPECT) imagery technique has become a great help in the diagnostic of cerebrovascular diseases which are the third most common cause of death in the USA and Europe. Nevertheless, SPECT images are very blurred and consequently their interpretation is difficult. In order to improve the spatial resolution of these images and then to facilitate their interpretation by the clinician, we propose to implement and to compare the effectiveness of different existing ‘‘blind’’ or ‘‘supervised’’ deconvolution methods. To this end, we present an accurate distribution mixture parameter estimation procedure which takes into account the diversity of the laws in the distribution mixture of a SPECT image. In our application, parameters of this distribution mixture are efficiently exploited in order to prevent overfitting of the noisy data for the iterative deconvolution techniques without regularization term, or to determine the exact support of the object to be restored when this one is needed. Recent blind deconvolution techniques such as the NAS–RIF algorithm, [D. Kundur and D. Hatzinakos, ‘‘Blind image restoration via recursive filtering using deterministic constraints,’’ in Proc. International Conf. On Acoustics, Speech, and Signal Processing, Vol. 4, pp. 547–549 (1996). ] combined with this estimation procedure, can be efficiently applied in SPECT imagery and yield promising results.
Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor

Until recently, steroid hormones were believed to act only on cells containing intracellular receptors. However, recent evidence suggests that steroids have specific and rapid effects at the cellular membrane. Using whole-cell patch-clamp techniques, 17 beta-estradiol was found to reduce Ba2+ entry reversibly via Ca2+ channels in acutely dissociated and cultured neostriatal neurons. The effects were sex-specific, i.e., the reduction of Ba2+ currents was greater in neurons taken from female rats. 17 beta-Estradiol primarily targeted L-type currents, and their inhibition was detected reliably within seconds of administration. The maximum reduction by 17 beta-estradiol occurred at picomolar concentrations. 17 beta-Estradiol conjugated to bovine serum albumin also reduced Ba2+ currents, suggesting that the effect occurs at the membrane surface. Dialysis with GTP gamma S prevented reversal of the modulation, suggesting that 17 beta-estradiol acts via G-protein activation. 17 alpha-Estradiol also reduced Ba2+ currents but was significantly less effective than 17 beta-estradiol. Estriol and 4-hydroxyestradiol were found to reduce Ba2+ currents with similar efficacy to 17 beta-estradiol, whereas estrone and 2-methoxyestriol were less effective. Tamoxifen also reduced Ba2+ currents but did not occlude the effect of 17 beta-estradiol. These results suggest that at physiological concentrations, 17 beta-estradiol can have immediate actions on neostriatal neurons via nongenomic signaling pathways.
Investigations on the incidence of rinderpest virus infection in game animals of N. Tanganyika and S. Kenya 1960/63

The incidence of rinderpest infection in game animals in selected localities of South Kenya and North Tanganyika was studied during the period 1960 to 1963. Serum samples from 590 wildebeest (Connochaetes taurinus), 48 eland (Taurotragus oryx), 65 Thompson's gazelle (Gazella thompsoni) and 39 Grant's gazelle (Gazella granti) were tested for rinderpest neutralizing antibody. Rinderpest infection was shown to have been very frequent in yearling wilde-beest in the Mara area of Kenya in 1959/60, in the Serengeti National Park of Tanganyika in late 1960 and also in the Serengeti, and some adjacent areas, during the latter half of 1961. In the Ngorongoro Crater in 1961 infection was far less widespread, with only 11% of the yearlings acquiring antibody, compared to 67% in the Serengeti. The infections in 1959 and 1960 were clinical epizootics, accompanied by a considerable mortality, whereas no overt disease was reported in the course of 1961. Eland were affected in a similar manner to wildebeest up to 1960 but only a low rate of serological conversion was demonstrated in 1961. Adult Thompson's gazelle showed a low rate (ca. 12%) of infection but no anti-body was detected in Grant's gazelle. Only a small proportion of the wildebeest calves born in early 1962 acquired antibody by mid-1963 and this was due, at least in part, to infection late in 1962; it was not clear, unfortunately, whether the positive animals belonged entirely to resident, as opposed to migratory, groups. No clinical signs or mortality were reported in this year. A low incidence of rinderpest infection in wildebeest was also demonstrated both before and after 1960 in the Kajiado district of Kenya, where disease of game has not been reported in recent years. It is possible that the positive animals, as also the 1962 cases in Tanganyika, acquired the virus from low-grade infections of cattle. The transmission of rinderpest antibody from wildebeest dam to calf, presumably via the colostrum, was demonstrated regularly, except in six calves about 1–2 weeks old. No completely satisfactory explanation was obtained for their failure to acquire passive antibody but it may have been due to abnormal disturbance in the herds, associated with the shooting. The antibody titres in calves were initially higher than those in the serum of their dams but by the end of the 3rd month this position had been reversed. Individual calves became serologically negative from about the 10th week of life and all were devoid of antibody by the 6th to 7th month. The half-life of passively-acquired antibody was 4·4 weeks.
Naive physics

The project of a 'naive physics J has been the subject of attention in recentyears above all in the artificial intelligencefield, in connectionwith work on common-sense reasoning, perceptual representation and robotics. The idea of a theory of the common-sense world is however much older than this, having its roots not least in the work of phenomenologists and Gestalt psychologists such as Kohler, Husserl, Schapp and Gibson. Thispaper seeks to show how contemporary naive physicists can profit from a knowledge of these historical roots of their discipline, which are shown to imply above all a critique of the set-theory-based models of reality typically presupposed by contemporary work in common-sense ontology [I}.
Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003-06.

AIMS Prolonged sedentary time is ubiquitous in developed economies and is associated with an adverse cardio-metabolic risk profile and premature mortality. This study examined the associations of objectively assessed sedentary time and breaks (interruptions) in sedentary time with continuous cardio-metabolic and inflammatory risk biomarkers, and whether these associations varied by sex, age, and/or race/ethnicity. METHODS AND RESULTS Cross-sectional analyses with 4757 participants (≥ 20 years) from the 2003/04 and 2005/06 US National Health and Nutrition Examination Survey (NHANES). An Actigraph accelerometer was used to derive sedentary time [< 100 counts per minute (cpm)] and breaks in sedentary time. Independent of potential confounders, including moderate-to-vigorous exercise, detrimental linear associations (P for trends < 0.05) of sedentary time with waist circumference, HDL-cholesterol, C-reactive protein, triglycerides, insulin, HOMA-%B, and HOMA-%S were observed. Independent of potential confounders and sedentary time, breaks were beneficially associated with waist circumference and C-reactive protein (P for trends <0.05). There was limited evidence of meaningful differences in associations with biomarkers by age, sex, or race/ethnicity. Notable exceptions were sex-differences in the associations of sedentary time and breaks with HDL-cholesterol, and race/ethnicity differences in the association of sedentary time with waist circumference with associations detrimental in non-Hispanic whites, null in Mexican Americans, and beneficial in non-Hispanic blacks. CONCLUSION These are the first population-representative findings on the deleterious associations of prolonged sedentary time with cardio-metabolic and inflammatory biomarkers. The findings suggest that clinical communications and preventive health messages on reducing and breaking up sedentary time may be beneficial for cardiovascular disease risk.
Beginning Teachers' Perceptions of Their Induction Program Experiences

Ensuring a qualified teacher in every classroom is a central part of the latest agenda to strengthen public education and maximize student achievement. Effective teaching and delivering quality instruction are lifelong and critical goals of professional development of teachers. High-quality induction programs support qualified teachers for every child. We evaluated perceptions of beginning teachers relative to the effectiveness of induction activities, assistance, and support provided within their school districts. Overall, this group indicated that induction programs were sufficient for them to succeed during the first years of teaching. Implications for improving practice and recommendations for continuing research are discussed in this article.
Research and Optimization of Prediction Structure of Multi-view Coding

This paper analysis the prediction structure based on layered B frame used by multi view video coding, introduces the common predictive structure and their evaluation index, proposes a kind of improved prediction structure, and makes comparative analysis on the performance of encoding time, PSNR and code rate by experiment which uses the typical test sequences Ball-room and Exit provided by MERL on the multi view video coding test platform. The experimental results show that: the improved prediction structure showed better coding efficiency; coding complexity reduction is up to 15%, the better to improve the real-time performance of code.
Model for a quantum Hall effect without Landau levels: Condensed-matter realization of the "parity anomaly"

A two-dimensional condensed-matter lattice model is presented which exhibits a nonzero quantization of the Hall conductance ${\ensuremath{\sigma}}^{\mathrm{xy}}$ in the absence of an external magnetic field. Massless fermions without spectral doubling occur at critical values of the model parameters, and exhibit the so-called "parity anomaly" of (2+1)-dimensional field theories.
Weakly Supervised One-Shot Detection with Attention Siamese Networks

We consider the task of weakly supervised one-shot detection. In this task, we attempt to perform a detection task over a set of unseen classes, when training only using weak binary labels that indicate the existence of a class instance in a given example. The model is conditioned on a single exemplar of an unseen class and a target example that may or may not contain an instance of the same class as the exemplar. A similarity map is computed by using a Siamese neural network to map the exemplar and regions of the target example to a latent representation space and then computing cosine similarity scores between representations. An attention mechanism weights different regions in the target example, and enables learning of the one-shot detection task using the weaker labels alone. The model can be applied to detection tasks from different domains, including computer vision object detection. We evaluate our attention Siamese networks on a one-shot detection task from the audio domain, where it detects audio keywords in spoken utterances. Our model considerably outperforms a baseline approach and yields a 42.6% average precision for detection across 10 unseen classes. Moreover, architectural developments from computer vision object detection models such as a region proposal network can be incorporated into the model architecture, and results show that performance is expected to improve by doing so.
Quasi-dependent variables in hybrid automata

The concept of hybrid automata provides a powerful framework to model and analyze real-world systems. Due to the structural complexity of hybrid systems it is important to ensure the scalability of analysis algorithms. We approach this problem by providing an effective generalisation of the recently introduced notion of quasi-equal clocks to hybrid systems. For this purpose, we introduce the concept of quasi-dependent variables. Our contribution is two-fold: we demonstrate how such variables can be automatically detected, and we present a transformation leading to an abstraction with a smaller state space which, however, still retains the same properties as the original system. We demonstrate the practical applicability of our methods on a range of industrial benchmarks.