Miracle-dz/UniFAR-FTUs huggingface dataset:
A complex containing LPP and &agr;-actinin mediates TGF&bgr;-induced migration and invasion of ErbB2-expressing breast cancer cells

Summary Transforming growth factor &bgr; (TGF&bgr;) is a potent modifier of the malignant phenotype in ErbB2-expressing breast cancers. We demonstrate that epithelial-derived breast cancer cells, which undergo a TGF&bgr;-induced epithelial-to-mesenchymal transition (EMT), engage signaling molecules that normally facilitate cellular migration and invasion of mesenchymal cells. We identify lipoma preferred partner (LPP) as an indispensable regulator of TGF&bgr;-induced migration and invasion of ErbB2-expressing breast cancer cells. We show that LPP re-localizes to focal adhesion complexes upon TGF&bgr; stimulation and is a critical determinant in TGF&bgr;-mediated focal adhesion turnover. Finally, we have determined that the interaction between LPP and &agr;-actinin, an actin cross-linking protein, is necessary for TGF&bgr;-induced migration and invasion of ErbB2-expressing breast cancer cells. Thus, our data reveal that LPP, which is normally operative in cells of mesenchymal origin, can be co-opted by breast cancer cells during an EMT to promote their migration and invasion.
Hepatitis E virus

Hepatitis E virus (HEV) is the aetiological agent of non‐HAV enterically transmitted hepatitis. It is the major cause of sporadic as well as epidemic hepatitis, which is no longer confined to Asia and developing countries but has also become a concern of the developed nations. In the Indian subcontinent, it accounts for 30–60% of sporadic hepatitis. It is generally accepted that hepatitis E is mostly self‐limited and never progresses to chronicity. It has a higher mortality in pregnant women where the disease condition is accentuated with the development of fulminant liver disease. Currently, no antiviral drug or vaccine is licensed for HEV, although a vaccine candidate is in clinical trials. HEV genome is 7.2kb in size with three open reading frames (ORFs) and 5′ and 3′ cis acting elements, which have important roles to play in HEV replication and transcription. ORF1 codes for methyl transferase, protease, helicase and replicase; ORF2 codes for the capsid protein and ORF3 for a protein of undefined function. HEV has recently been classified in the genus Hepevirus of the family Hepeviridae. There are four major recognised genotypes with a single known serotype. The absence of a reliable in vitro propagation system is an obstacle to deciphering HEV biology. The genome of HEV has been cloned, sequenced and the infectious nature of these replicons has been established. However, questions related to replication, transcription, virus‐host interactions and pathogenesis remain to be answered. This comprehensive review summarises the progress made so far in HEV research, and addresses some of the unanswered questions. Copyright © 2006 John Wiley & Sons, Ltd.
Appraisal Antecedents of Shame and Guilt: Support for a Theoretical Model

Four studies used experimental and correlational methods to test predictions about the antecedents of shame and guilt derived from an appraisal-based model of self-conscious emotions (Tracy & Robins, 2004). Results were consistent with the predicted relations between appraisals (i.e., causal attributions) and emotions. Specifically, (a) internal attributions were positively related to both shame and guilt; (b) the chronic tendency to make external attributions was positively related to the tendency to experience shame; and (c) internal, stable, uncontrollable attributions for failure were positively related to shame, whereas internal, unstable, controllable attributions for failure were positively related to guilt. Emotions and attributions were assessed using a variety of methods, so converging results across studies indicate the robustness of the findings and provide support for the theoretical model.
Social‐emotional adjustment of deaf students. Teachers' ratings of deaf children: An American‐Danish comparison

Teachers' ratings of their hearing-impaired students in Denmark and the United States were collected and compared. The instrument used was the Meadow/Kendall Social Emotional Assessment Inventory (SEAI), specifically constructed for use with this population. American students from day programs (N = 364) and from residential programs (N = 368) were compared with Danish students from day programs (N = 289). When age was controlled, scores on the three subscales (social adjustment, emotional adjustment, self-image) were almost identical. Differences on 29 of the 59 individual items likewise were not significant.Additional item analyses suggested that Danish teachers may value modesty, reserve, and introspective and individually focused attitudes and behaviors, whereas American teachers are more likely to value assertiveness, creativity, and extroverted and group-focused behaviors. Both groups of teachers gave their students generally low ratings on items reflecting motivation, independence, and initiative. The suggestion was made that parents and teachers need to reassess opportunities given to hearing-impaired children to develop independence and responsibility, qualities important for maturity.The conclusion is reached that the Danish and American children are evaluated by their teachers as having very similar levels of overall social and emotional functioning. The content of evaluations leading to that result was similar to some extent: Approximately half the individual inventory items showed no differences among the groups. The shift in high and low ratings on additional items led to the suggestion that cultural differences played a role in determining the content of definition of adjustment to some limited extent.
Model-based Overlapping Co-Clustering

Co-clustering or simultaneous clustering of rows and colum ns of two-dimensional data matrices, is a data mining technique w ith various applications such as text clustering and microarra y an lysis. Most proposed co-clustering algorithms work on the data mat rices with special assumptions and they also assume the existence of a number of mutually exclusive row and column clusters, but it is believed that such an ideal structure rarely exists in real d ata. In this paper, we propose an overlapping co-clustering model w hich is able to work with any regular exponential family distributi on, and corresponding Bregman divergences, thereby making the mod el applicable to a wide variety of clustering distance functio ns. The algorithm using a generative model is able to discover overl apping co-clusters in the input data matrix. The necessary algorit hms are provided for this model, and the effectiveness of the met hod is demonstrated through experiments on subsets of Reuters a nd MovieLens datasets compared to several other clustering me thods.
Congruency among experience dimensions, condition indicators, and coping behaviors in wilderness

Abstract Understanding the way that policy translates into experiences, perceptions, and behaviors is important to managing recreation in wilderness. The limits of acceptable change (LAC) planning system was used to structure a relationship between three constructs: experience dimensions (goals), conditions of concern (condition indicators), and coping behaviors (actions) in wilderness recreation. The Wilderness Act of 1964 served as a conceptual basis, providing five descriptors: natural, solitude, primitive, unconfined, and remote; these were used to develop experience, condition, and behavior measures. Recreationists from two wildernesses in the southeastern United States were sampled and asked to participate in a mail survey. Results indicated that wilderness experience dimensions existed that reflected the five descriptors, and that these dimensions were congruent with the constructs representing perceived conditions and coping behaviors. Natural and solitude aspects of the recreational experience we.
Family Structure and Mental Health: The Mediating Effects of Socioeconomic Status, Family Process, and Social Stress∗

Although numerous studies reveal differences in mental health by the structure of one's family of origin, there remains debate regarding the processes generating these patterns. Using a sample of young adults (19–21 years) in Miami-Dade County in Florida, this study examines the explanatory significance of three presumed correlates of family type: socioeconomic status, family processes, and level of social stress. Consistent with prior research, our results reveal higher levels of depressive symptoms among those from stepfamilies, single parent families, and single parent families with other relatives present, compared with mother-father families. All three presumed correlates make significant independent contributions to the prediction of depressive symptomatology. Substantial mediating effects also are observed for all three explanatory dimensions. Collectively, they completely or largely explain observed family type variations in mental health risk.
Correlation between veterinary antimicrobial use and antimicrobial resistance in food-producing animals: a report on seven countries.

OBJECTIVES To evaluate correlations between antimicrobial use and the prevalence of resistance in commensal Escherichia coli isolates from pigs, poultry and cattle, using data from publicly available national or international reports from seven European countries. METHODS The link between the quantities of different classes of antimicrobials administered to food-producing animals per country (expressed in mg/population correction unit) and the prevalence of resistance to the different antimicrobial classes (interpreted by EUCAST epidemiological cut-off values) in E. coli isolates (4831 isolates in total) was assessed by means of polynomial regression analysis and determination of Spearman's rank correlation coefficient. RESULTS A quadratic regression best fitted the antimicrobial use and antimicrobial resistance data. The coefficient of determination was, in decreasing order, 0.99 for fluoroquinolones and amphenicols, 0.94 for third-generation cephalosporins and sulphonamides, 0.93 for aminopenicillins, 0.86 for fluoroquinolones, 0.81 for streptomycin and 0.80 for gentamicin and tetracycline. Spearman's rank correlation coefficient was 1 for amphenicols, 0.96 for sulphonamides, 0.93 for streptomycin and tetracycline, 0.89 for aminopenicillins, 0.71 for gentamicin and 0.70 for third-generation cephalosporins. CONCLUSIONS These remarkably high coefficients indicate that, at a national level, the level of use of specific antimicrobials strongly correlates to the level of resistance towards these agents in commensal E. coli isolates in pigs, poultry and cattle. However, data restraints reveal the need for further detail in collection and harmonization of antimicrobial resistance and use data in Europe.
Multicast feedback suppression using representatives

For a reliable, feedback dependent multicast transport protocol to scale, it must avoid the feedback implosion problem, particularly if the protocol targets arbitrarily large multicast groups communicating over lossy networks. Most existing suppression based feedback control mechanisms address the implosion problem using timers based on round-trip time (RTT) estimates between each receiver and the source. The algorithm presented has three major benefits: it does not need to compute the RTT from all receivers to the source, does not require knowledge of group membership, and provides prompt feedback. A small set of representative receivers and probabilistic suppression are used to limit feedback. We believe that this approach will perform well in real networks. Simulations show that for various multicast group sizes, a few representatives can keep the amount of feedback low while not degrading feedback timeliness.
Children's Mental Health Policy: Challenging the Future

Professionals have recently recognized the depth and complexity of emotional and behavioral disorders of America's children. Among those who grasped the scope of the problem early, some have taken strides toward creating more useful concepts and practices, including reconsiderations of issues involving the child's family, treating intensive problems, community locus for services, and multicultural considerations. Such innovations are not predestined to survive and prosper; however, proponents of the new approaches must take steps to raise the chances that gains will be solidified. We need to broaden the base of research and knowledge, establish mechanisms ensuring collaborative work across the disciplines, pass laws that will support the changes, offer help to children before they are identified with emotional and behavioral disorders, train professionals in the new service delivery concepts and practices, and reform mechanisms for financing services.
Preschoolers' physical activity behaviours: parents' perspectives.

OBJECTIVES To understand parents' perspectives of their preschoolers' physical activity behaviours. METHODS A maximum variation sample of 71 parents explored their preschoolers' physical activity behaviours through 10 semi-structured focus group discussions. RESULTS Parents perceived Canada's Physical Activity Guidelines for Children as inadequate; that their preschoolers get and need more than 30-90 minutes of activity daily; and that physical activity habits must be established during the preschool years. Nine barriers against and facilitators toward adequate physical activity were proposed: child's age, weather, daycare, siblings, finances, time, society and safety, parents' impact, and child's activity preferences. DISCUSSION The need for education and interventions that address current barriers are essential for establishing physical activity as a lifestyle behaviour during early childhood and, consequently, helping to prevent both childhood and adulthood obesity.
L1-Regularized Least Squares for Support Recovery of High Dimensional Single Index Models with Gaussian Designs

It is known that for a certain class of single index models (SIMs) [Formula: see text], support recovery is impossible when X ~ 𝒩(0, 𝕀 p×p ) and a model complexity adjusted sample size is below a critical threshold. Recently, optimal algorithms based on Sliced Inverse Regression (SIR) were suggested. These algorithms work provably under the assumption that the design X comes from an i.i. d. Gaussian distribution. In the present paper we analyze algorithms based on covariance screening and least squares with L1 penalization (i.e. LASSO) and demonstrate that they can also enjoy optimal (up to a scalar) rescaled sample size in terms of support recovery, albeit under slightly different assumptions on f and ε compared to the SIR based algorithms. Furthermore, we show more generally, that LASSO succeeds in recovering the signed support of β0 if X ~ 𝒩 (0, Σ), and the covariance Σ satisfies the irrepresentable condition. Our work extends existing results on the support recovery of LASSO for the linear model, to a more general class of SIMs.
An Efficient Mining of Sequential Rules Using Vertical Data Format

Data mining is the method of analyzing data from different perspectives and summarizing it into useful information. Among the various data mining tasks sequential pattern mining is one of the most important tasks. Sequential pattern mining consists of mining subsequences that appear frequently in a set of sequences. The vertical representation allows generating patterns using depth-first search to discover patterns and calculating their supports without performing costly database scans. CMAP can be used to prune candidates in vertical Algorithms like SPAM. Although there have been studies on the sequential patterns and CM-SPAM algorithm is not generating rules Keywordssequential pattern mining; sequential rule mining; vertical database format; candidate pruning; Apriori.
Can Resource Dependence and Coercive Isomorphism Explain Nonprofit Organizations’ Compliance With Reporting Standards?

Nonprofit organizations worldwide are confronted with an increasing demand for accountability and improved financial transparency. Financial reporting by nonprofit organizations is no longer an exception; it has become a rule.The usefulness of a financial report to an organization’s stakeholders depends on its quality. The latter is safeguarded by reporting standards as well as the commitment of the organization to fully implement these standards. Although resource dependence and coercive isomorphism have been used in earlier nonprofit organization research, no empirical research has linked these theories to compliance with financial reporting standards. Using a unique setting in which a large number of (very) large Belgian nonprofit organizations are confronted with far-reaching changes in financial reporting regulations, the effect of resource dependence and coercive isomorphism on accounting and financial reporting compliance is documented.
Mass Murder at School and Cumulative Strain

To explain the genesis of mass murder committed by students at their schools, the authors propose a five-stage sequential model in which several criminological theories (strain theory, control theory, and routine activities theory) are brought to bear collectively to demonstrate their cumulative effect. These stages are as follows: chronic strain, uncontrolled strain, acute strain, the planning stage, and the massacre. Long-term frustrations (chronic strains) experienced early in life or in adolescence lead to social isolation, and the resultant lack of prosocial support systems (uncontrolled strain) in turn allows a short-term negative event (acute strain), be it real or imagined, to be particularly devastating. As such, the acute strain initiates a planning stage, wherein a mass killing is fantasized about as a masculine solution to regain lost feelings of control, and actions are taken to ensure the fantasy can become reality. The planning process concludes in a massacre facilitated by weapons that enable mass destruction in schoolrooms and campuses, where students are closely packed together. Based on this analysis, prevention strategies are suggested.
Cardiovascular risk following widowhood: increasing clarity from new research models.

Bereavement is a common life event that will affect all of us at some point in time and demands research attention. The death of a spouse or other close relative is generally considered to be one of the most stressful of human experiences. The association between bereavement and increased health risk has been the subject of widowhood studies over the past 60 years, with substantial evidence suggesting increased mortality among the surviving spouses. A landmark British study of 4486 widowers of 55 years or older revealed an excess death rate as high as 40% compared with that of a sample of married men in the first 6 months of bereavement, which reduced to the risk amongmarried men after 6 months [1]. A 9-year follow-up revealed that death with a diagnosis of coronary thrombosis accounted for 53% of the reported increased mortality [2]. However, major limitations in much of the spouse bereavement research include lack of homogeneity and sample sizes, lack of a priori theory, absence of established health outcomes, and retrospectivity in design [3], with data generated from large cross-sectional and longitudinal epidemiological studies and from health maintenance organizations in the USA [4], as well as explorations of healthcare utilization and costs [5]. Short-term morbidity in the early weeks and months of bereavement has also been researched at intervals since the 1950s [6]. These reports have generally included nonspecific complaints.
A Study on Posttraumatic Stress Disorder Among North Korean Defectors and their Social Adjustment in South Korea

The purposes of this study were (a) to evaluate the level of social adjustment of North Korean defectors, (b) to analyze the differences in social adjustment between post-traumatic stress disorder (PTSD) high-risk and low-risk groups among North Korean defectors, and (c) to determine factors, including PTSD and other related variables, that influence defectors' social adjustment in South Korea. North Korean defectors aged 18 and over were sampled using a snowball sampling method. A total of 133 cases were analyzed by hierarchical regression. Results revealed that the level of social adjustment among the defectors was rather poor, and social adjustment between the PTSD high- and low-risk groups was statistically different. The variables affecting social adjustment among the defectors included level of PTSD symptoms, self-rated economic status, job status, and gender, with PTSD symptom levels having a greater impact on social adjustment than other variables. A number of implications for the successful adjustment of North Korean defectors to South Korean society are presented.
Topological Interference Management for Hexagonal Cellular Networks

We consider the topological interference management problem for a downlink hexagonal cellular network, where the channel state information at the transmitters is limited to just the network topology. Recent work by Jafar showed that if interference is limited to only near the cell boundary, then, an aligned frequency reuse pattern achieves the optimal value of 6/7 degrees of freedom (DoF) per cell, as opposed to the conventional frequency reuse baseline of 1/3 DoF per cell. We generalize the setting to include interference from multiple layers of adjacent cells and characterize how the gains of the optimal solution over basic frequency reuse diminish with increasing number of interference layers. Next, we focus on single-layer interference and explore the sensitivity of the idealized assumptions behind the connectivity model of Jafar, which achieves higher DoF but only at the cost of a higher effective noise floor than the baseline, and under idealized placements of users. A modified connectivity model that operates at a comparable noise-floor to the baseline is then studied, and its DoF are shown to be bounded above by 6/11 and below by 1/2. Through numerical simulations, we compare the solutions that achieve 6/7, 1/2, and 1/3 DoF per cell and find that, while both the 6/7 and the 1/2 DoF solutions beat the baseline 1/3 figure, between them, the 1/2 DoF aligned frequency reuse pattern is more robust for small cell networks particularly for random users' distribution on the cell boundaries.
Central Blood Pressure and Chronic Kidney Disease Progression

Hypertension, diabetes, and proteinuria are well-recognized risk factors for progressive kidney function loss. However, despite excellent antihypertensive and antidiabetic drug therapies, which also often lower urinary protein excretion, there remains a significant reservoir of patients with chronic kidney disease who are at high risk for progression to end-stage kidney disease. This has led to the search for less traditional cardiovascular risk factors that will help stratify patients at risk for more rapid kidney disease progression. Among these are noninvasive estimates of vascular structure and function. Arterial stiffness, manifested by the pulse wave velocity in the aorta, has been established in a number of studies as a significant risk factor for kidney disease progression and cardiovascular endpoints. Much less well studied in chronic kidney disease are measures of central arterial pressures. In this paper we cover the physiology behind the generation of the central pulse wave contour and the studies available using these approaches and conclude with some speculations on the rationale for why measurements of central pressure may be informative for the study of chronic kidney disease progression.