Miracle-dz/UniFAR-FTUs huggingface dataset:
Work-related Stressors of Female Teachers During Covid-19 School Closure

In Slovakia, the Covid-19 pandemic lockdown in the educational sector lasted for three months and caused unexpected changes with demands on pupils and their parents, students and teachers. The global school closure at all educational levels occurred suddenly and caught the school system and its actors unprepared. Teachers were forced to quickly adapt to the “new” work approach with minimal and/or confusing directions. Female teachers who predominate at primary schools in Slovakia, around 90%, faced even greater challenge and experienced stress, as many of them simultaneously took care of their own children and households. The aim of the presented paper is an examination of stress level that primary school female teachers experienced during the schools´ lockdown period. Two measures of stress were used: Teacher stressor questionnaire (Clipa, Boghean, 2015) and the Perceived stress scale (Cohen, Kamarck & Mermelstein, 1983). Additionally, an open question was added to learn about the teachers´ subjective perception of work pressure caused by the lockdown. The research sample consisted of 103 female primary school teachers (47 at the first primary education stage, 56 at the second primary education stage). Data were collected online in April 2020, with teachers being invited to participate via teachers´ online forums.
IOT BASED SMART HOME AUTOMATION SYSTEM

: The Internet of Things (IoT) is the network of devices such as vehicles, and home devices that contain electronics, software, actuators, connectivity which allows these things to connect, interact and exchange data. Automation is the technology by which a process is performed with minimum human efforts. Automation or automatic control is the use of discrete control systems for operating equipment. This paper is focused on five different techniques such as home automation system by using symmetric encryption scheme, Eet-based Smart Home intelligent system, by using set of sensors, low-cost Wi-Fi based automation system for Smart Home, monitoring and controlling the home appliances via World Wide Web. Even though, some issues arises in every method which are analyzed in analysis and discussion section. To improve these issues, this paper has proposed a new home automation technique with the use of IOT, so as to reduce the existing problems and make home automation more smart and secure.
A qualitative study of avian influenza A H5N1 at the human-animal interface : examining constructions of risk and associated behaviours of people who work with poultry in three live bird markets in Indonesia

This thesis draws on the notion of disease narratives to examine the manner in which people who work with poultry (PWP) in live bird markets (LBMs) construct risks associated with avian influenza A H5N1, as well as how these constructions of risk inform behaviours at the human-animal interface. Focusing on PWP in three live bird markets in Indonesia, this qualitative study employs a constructivist perspective to look at what informs PWP’s constructions of risk about avian influenza in relation to themselves, their animals, their livelihoods, and the political authorities within their communities, and offers insight into the extent to which these constructions of risk underpin their behaviours. Although not strictly designed as a comparative study, this research draws out similarities and differences across the three fieldsites. Findings suggest that PWP assess risk by drawing on experiential knowledge and observations. Respondents across the three sites suggest a theory of species-specific infection in relation to H5N1, which broadly posits that there are certain diseases that infect different types of poultry and certain diseases that infect humans. For most PWP, diseases in birds are not considered contagious, even between different species, and the possibility of zoonosis implausible. The majority of respondents conclude that humans are not susceptible to poultry diseases because their observations and experiences do not support such a conclusion. PWP do, however, indicate that other forms of risk, such as the risk that a disease outbreak or an intervention can threaten their livelihood are plausible and salient. Behaviours of PWP at the human-animal interface reflect their constructions of risk, in that they prioritize economic considerations over any concern for mitigating the risk of disease in poultry or in people. This thesis concludes by outlining policy implications and researchable hypotheses, and in highlighting the benefits as well as the challenges of integrating qualitative, social science research into the interdisciplinary, collaborative study of emerging infectious diseases.
A 12-week lifestyle intervention: effects on fatigue, fear, and nutritional status in children with a Fontan circulation

Introduction Children and adolescents with a Fontan circulation are less physically active compared to healthy peers. In the current study, effects of a 12-week lifestyle intervention on fatigue, fears regarding exercise, caloric intake, rest energy expenditure (REE), and body composition were measured in children with a Fontan circulation. Methods This study was a semi-cross-over randomized controlled trial. The lifestyle intervention consisted of a 12-week high-weight resistance training (three supervised training sessions a week) supported by high-protein diet (>2 g/kg) and tailored recommended caloric intake. Fatigue (measured by the validated PedsQol Multidimensional Fatigue Scale), fears regarding exercise (measured on a fear thermometer), REE (measured using indirect calorimetry), caloric intake and body composition using air displacement plethysmography, and four-skinfold method were measured before and after the intervention and control period. Results Twenty-seven pediatric Fontan patients, median age 12.9 years (IQR: 10.5–16.2), of the included 28 patients successfully completed the program. Before training, both child- and parent-reported levels of fatigue were significantly worse on all domains (general, sleep/rest, and cognitive fatigue) compared to healthy peers. After training, parent-reported fatigue significantly improved on the general and cognitive fatigue domains [effect size +16 points (7–25), p < 0.001, and +10 points (2–17), p = 0.015, compared to the control period]. Before training, fear regarding exercise scored on the fear thermometer was low for both children and parents (median score 1 and 2, respectively, on a scale of 0–8). After training, child-reported fear decreased further compared to the control period [effect size −1.4 points (−2.3 to −0.6), p = 0.001]. At baseline, children had increased REE +12% compared to reference values, which did not change after exercise. Children ate an average of 637 calories below recommended intake based on REE, caloric deficit became smaller after the intervention, and protein intake increased compared to the control period [−388 calories (−674 to −102), p = 0.008, and +15 g (0.4–30), p = 0.044]. Body fat percentage did not change significantly. Conclusion A 12-week lifestyle intervention improved parent-reported fatigue symptoms in the children, further decreased child-reported fears, and increased caloric and protein intake.
FELODIPINE-REVIEW OF ANALYTICAL METHODS DEVELOPED FOR PHARMACEUTICAL DOSAGE FORMS AND BIOLOGICAL FLUIDS

Felodipine (FDP) is a vascular selective L-type calcium channel blocker, in hypertension patients FDP significantly lowers systolic and diastolic blood pressure (BP). It is a lipophilic drug molecule that contains a dihydropyridine ring responsible to show pharmacological activity, it is mainly used to control and prevent essential hypertension. This review article provides a summary of various analytical techniques for determining felodipine in pure form, pharmaceutical formulations, and biological fluids. Various analytical techniques are developed and validated, such as ultraviolet/visible spectrophotometry, high-performance liquid chromatography (HPLC), high-performance thin layer chromatography (HPTLC), and bioanalytical techniques. Estimated validation parameters such as linearity, LOD (Limit of Detection), and LOQ (Limit of Quantification) are discussed for each method. The wavelength of detection (λmax), mobile phase, columns, flow rate, retention time (Rt) and sample preparation techniques are all important quality elements for calculating Felodipine via analytical procedures.
Identification of immune-related genes in diagnosing retinopathy of prematurity with sepsis through bioinformatics analysis and machine learning

Background: There is increasing evidence indicating that immune system dysregulation plays a pivotal role in the pathogenesis of retinopathy of prematurity (ROP) and sepsis. This study aims to identify key diagnostic candidate genes in ROP with sepsis. Methods: We obtained publicly available data on ROP and sepsis from the gene expression omnibus database. Differential analysis and weighted gene correlation network analysis (WGCNA) were performed to identify differentially expressed genes (DEGs) and key module genes. Subsequently, we conducted functional enrichment analysis to gain insights into the biological functions and pathways. To identify immune-related pathogenic genes and potential mechanisms, we employed several machine learning algorithms, including Support Vector Machine Recursive Feature Elimination (SVM-RFE), Least Absolute Shrinkage and Selection Operator (LASSO), and Random Forest (RF). We evaluated the diagnostic performance using nomogram and Receiver Operating Characteristic (ROC) curves. Furthermore, we used CIBERSORT to investigate immune cell dysregulation in sepsis and performed cMAP analysis to identify potential therapeutic drugs. Results: The sepsis dataset comprised 352 DEGs, while the ROP dataset had 307 DEGs and 420 module genes. The intersection between DEGs for sepsis and module genes for ROP consisted of 34 genes, primarily enriched in immune-related pathways. After conducting PPI network analysis and employing machine learning algorithms, we pinpointed five candidate hub genes. Subsequent evaluation using nomograms and ROC curves underscored their robust diagnostic potential. Immune cell infiltration analysis revealed immune cell dysregulation. Finally, through cMAP analysis, we identified some small molecule compounds that have the potential for sepsis treatment. Conclusion: Five immune-associated candidate hub genes (CLEC5A, KLRB1, LCN2, MCEMP1, and MMP9) were recognized, and the nomogram for the diagnosis of ROP with sepsis was developed.
Série Scientifique Scientific Series Are the Effects of Monetary Policy Asymmetric? Are the Effects of Monetary Policy Asymmetric?

Ce document est publié dans l'intention de rendre accessible les résultats préliminaires de la recherche effectuée au CIRANO, afin de susciter des échanges et des suggestions. Les idées et les opinions émises sont sous l'unique responsabilité des auteurs, et ne représentent pas nécessairement les positions du CIRANO ou de ses partenaires. This paper presents preliminary research carried out at CIRANO and aims to encourage discussion and comment. The observations and viewpoints expressed are the sole responsibility of the authors. They do not necessarily represent positions of CIRANO or its partners. CIRANO Le CIRANO est une corporation privée à but non lucratif constituée en vertu de la Loi des compagnies du Québec. Le financement de son infrastructure et de ses activités de recherche provient des cotisations de ses organisations-membres, d'une subvention d'infrastructure du ministère de l'Industrie, du Commerce, de la Science et de la Technologie, de même que des subventions et mandats obtenus par ses équipes de recherche. La Série Scientifique est la réalisation d'une des missions que s'est données le CIRANO, soit de développer l'analyse scientifique des organisations et des comportements stratégiques. CIRANO is a private non-profit organization incorporated under the Québec Companies Act. Its infrastructure and research activities are funded through fees paid by member organizations, an infrastructure grant from the Ministère de l'Industrie, du Commerce, de la Science et de la Technologie, and grants and research mandates obtained by its research teams. The Scientific Series fulfils one of the missions of CIRANO: to develop the scientific analysis of organizations and strategic behaviour. Les organisations-partenaires / The Partner Organizations Ministère de l'Industrie, du Commerce, de la Science et de la Technologie. École des Hautes Études Commerciales. École Polytechnique. Université de Montréal. Université Laval. McGill University. Université du Québec à Montréal. Bell Québec. La Caisse de dépôt et de placement du Québec. Hydro-Québec. Banque Laurentienne du Canada. Fédération des caisses populaires de Montréal et de l'Ouest-du-Québec. Téléglobe Canada. and the Econometric Society for helpful comments and the SSHRC and FCAR for financial support. Abstract / Résumé This paper focuses on whether monetary policy has asymmetric effects. By building on the Markov switching model introduced by Hamilton (1989), we examine questions like: Does monetary policy have the same effect regardless of the current phase of economic fluctuations? Given that the economy is currently in a recession, does a fall in interest rates increase the probability of an expansion? Does monetary policy …
The Cognitive Connectome in Dementia with Lewy Bodies

Objectives: Cognition plays a central role for diagnosing and characterizing dementia with Lewy bodies (DLB). However, the complex associations among cognitive functions are largely unknown in DLB. To fill this gap, we compared the cognitive connectome of DLB patients, healthy controls (HC) and patients with Alzheimer's disease (AD). Methods: We obtained data from the National Alzheimers Coordinating Center (NIA/NIH Grant U24-AG072122). We built separate cognitive connectomes for DLB (n=104), HC (n= 3703), and AD (n=1985) groups using pairwise correlations between 24 cognitive variables mapping multiple cognitive functions. The cognitive connectomes in DLB, HC, and AD groups were compared using standard global and nodal graph measures of centrality, integration, and segregation. Results: In global connectome measures, DLB patients showed a higher global efficiency (integration) and lower transitivity (segregation) than HCs and AD. Nodal connectome measures showed a higher global efficiency in most cognitive functions in DLB compared to HCs. Additionally, we found a lower local efficiency (segregation) and nodal strength (centrality) in memory variables and a higher participation coefficient in executive variables (centrality) in DLB compared with both HCs and AD. Conclusions: The cognitive connectome in DLB showed a signature dedifferentiation pattern of aberrant correlations. Executive, processing speed and attention functions played a central role in the cognitive connectome of DLB patients. Furthermore, the role of executive and memory functions in the cognitive connectome distinguished DLB and AD patients. These findings may help advance our understanding of the clinical phenotype in DLB, and continue to improve the challenging differential diagnosis between DLB and AD.
Scorpio and centipede ameliorate asthma by inhibiting the crosstalk between ferroptosis and inflammation in airway epithelial cells

Objective(s): We previously revealed that scorpio and centipede (SC) improve the inflammatory response in asthma, whereas it is unclear whether ferroptosis is involved in this process. Materials and Methods: The asthmatic mouse model was established and lung tissues were collected for histopathological examination. The levels of tumor necrosis factor-α (TNF-α), interleukin- (IL-)1β, Fe2+, malondialdehyde (MDA), glutathione peroxidase 4 (GPX4), ferritin heavy chain 1(FTH1), and reactive oxygen species (ROS) were assessed in asthmatic mice and mouse airway epithelial cells. Results: Our results showed that ferroptosis was induced in asthmatic mice, as evidenced by the reduction of FTH1 and GPX4 expression and the increase of MDA and Fe2+ levels (all P<0.05). Ferrostatin-1 repressed inflammation and ferroptosis of asthmatic mice. Additionally, SC significantly inhibited the levels of TNF-α, IL-1β, MDA, and Fe2+, while enhancing FTH1 and GPX4 expression. However, SC plus erastin showed the reverse results. Moreover, ferroptosis remarkably increased in asthmatic airway epithelial cells, while SC suppressed ferroptosis of the cells (all P<0.05). Conclusion: SC ameliorated asthma by inhibiting the crosstalk between ferroptosis and inflammation in airway epithelial cells.
A Brief History of the 1987 Stock Market Crash With a Discussion of the Federal Reserve Response

The 1987 stock market crash was a major systemic shock. Not only did the prices of many financial assets tumble, but market functioning was severely impaired. This paper reviews the events surrounding the crash and discusses the response of the Federal Reserve, which responded in a number of ways to support the operation of financial markets, including the provision of liquidity, in a highly visible fashion.
Insights into the radiotherapy-induced deferentially expressed RNAs in colorectal cancer management

Radiotherapy (RT) has been commonly applied to treat advanced local cancers. In radiation therapy, high doses of radiation are utilized to trigger cell death. Radiation often leads to DNA double-strand breakages (DSB), which causes the activation of downstream genes including those for non-coding RNAs (ncRNA) such as long non-coding and RNAsmicro RNAs. The consequence of RT significantly relies on the radiosensitivity of cancer cells, which is affected by multiple factors, including some proteins and cellular processes. Activation of these genes can cause cell cytotoxicity and indirectly damages the cells. Recent studies have shown that non-coding RNAs can play as radiosensitivity or radioinhibitory regulators in cancers by mechanisms such as cell cycle arrest or affecting the DNA damage repair systems. ncRNAs are also known to function as tumor suppressor genes or oncogenes in colorectal cancer and therefore are considered potential diagnostic biomarkers in disease detection. For example, the investigations have shown that miR-29a and miR-224 can be informative biomarkers for early detection or screening of CRC via a noninvasive method such as liquid biopsy. Here, we discuss ncRNAs involved in the radioresistance and radiosensitivity of CRC and highlight their predictive clinical value in response to RT. Accordingly, this review represents a principal guide in the context of three major types of ncRNAs with potential roles in the pathway of radiosensitivity and radioresistance, including miRNAs, lncRNAs, and circRNAs which can be considered a precious archivement in organizing additional studies and broadening views in this area. Our findings can also assist radiotherapists in predicting CRC patients’ response and, therefore, prognosis to radiation therapy, although, to achieve our goals in the clinic, we certainly need further studies.
Functional traits and drought strategy predict leaf thermal tolerance

ABSTRACT Heat stress imposes an important physiological constraint on native plant species—one that will only worsen with human-caused climate change. Indeed, rising temperatures have already contributed to large-scale plant mortality events across the globe. These impacts may be especially severe in cities, where the urban heat island effect amplifies climate warming. Understanding how plant species will respond physiologically to rising temperatures and how these responses differ among plant functional groups is critical for predicting future biodiversity scenarios and making informed land management decisions. In this study, we evaluated the effects of elevated temperatures on a functionally and taxonomically diverse group of woody native plant species in a restored urban nature preserve in southern California using measurements of chlorophyll fluorescence as an indicator of leaf thermotolerance. Our aim was to determine if species’ traits and drought strategies could serve as useful predictors of thermotolerance. We found that leaf thermotolerance differed among species with contrasting drought strategies, and several leaf-level functional traits were significant predictors of thermotolerance thresholds. Drought deciduous species with high specific leaf area, high rates of transpiration and low water use efficiency were the most susceptible to heat damage, while evergreen species with sclerophyllous leaves, high relative water content and high water use efficiency maintained photosynthetic function at higher temperatures. While these native shrubs and trees are physiologically equipped to withstand relatively high temperatures in this Mediterranean-type climate, hotter conditions imposed by climate change and urbanization may exceed the tolerance thresholds of many species. We show that leaf functional traits and plant drought strategies may serve as useful indicators of species’ vulnerabilities to climate change, and this information can be used to guide restoration and conservation in a warmer world.
Foreign-born women rated medical and emotional aspects of postnatal care higher than women born in Sweden: A quantitative comparative study

INTRODUCTION Although high-quality postnatal care provides information and recognizes women’s personal and cultural contexts, foreign-born women are more exposed to poor health and adverse birth outcomes. The aim of this study was to compare the length and model of postnatal care, along with the content of care, between foreign-born and native-born women living in Sweden. Another aim was to explore factors associated with being very satisfied with various aspects of postnatal care. METHODS This was a descriptive cross-sectional study of 483 postnatal women in two Swedish hospitals in 2017. Women completed a questionnaire comprising background data, pregnancy and birth related variables and the Early Postnatal Questionnaire. Data were analyzed using descriptive statistics, analysis of variance and multivariate logistic regression analyses. RESULTS Foreign-born women were more likely to have a shorter (<24 h) or longer (>48 h) length of postnatal stay than women born in Sweden. No differences in birth outcomes emerged between the two groups. Foreign-born women rated the medical (OR=1.77; 95% CI: 1.04–3.03) and emotional (OR=2.0; 95% CI: 1.17–3.40) aspects of postnatal care as being more important than Swedish-born women did. The most important aspect of overall satisfaction was the content of care, and the subscale Caring Relationship (AOR=8.15; 95% CI: 4.87–14.62) outscored all other aspects. CONCLUSIONS Important factors of satisfactory experiences with postnatal care in a Swedish context were receiving information, professional care, and a hospital environment that facilitates recovery after labor and birth. Culturally sensitive and individualized postnatal care with continuity should therefore be prioritized.