Miracle-dz/UniFAR-FTUs huggingface dataset:
Y-Chromosome Analysis in Retuertas Horses

Several studies based on a variety of genetic markers have attempted to establish the origins of horse domestication. Thus far a discrepancy between the results of mitochondrial DNA analysis, which show high levels of diversity, and results from the Y-chromosome, with almost no genetic variability, has been identified. Most previous work on the horse Y-chromosome has focused on widespread, popular breeds or local Asian breeds. It is possible that these breeds represent a reduced set of the genetic variation present in the species. Additional genetic variation may be present in local breeds and ancient feral populations, such as the Retuertas horse in Spain. In this study we analyzed the Y-chromosome of the Retuertas horse, a feral horse population on the Iberian Peninsula that is at least several hundred years old, and whose genetic diversity and morphology suggests that it has been reproductively isolated for a long time. Data from the Retuertas horse was compared to another 11 breeds from the region (Portugal, Spain and France) or likely of Iberian origin, and then to data from 15 more breeds from around the globe. We sequenced 31 introns, Zinc finger Y-chromosomal protein (ZFY) and anonymous Y-linked fragments and genotyped 6 microsatellite loci found on the Y-chromosome. We found no sequence variation among all individuals and all breeds studied. However, fifteen differences were discovered between our data set and reference sequences in GenBank. We show that these likely represent errors within the deposited sequences, and suggest that they should not be used as comparative data for future projects.
Age-Related Changes in Temporal Allocation of Visual Attention: Evidence From the Rapid Serial Visual Presentation (RSVP) Paradigm

The present study explored the temporal allocation of attention in groups of 8-year-old children, 10-year-old children, and adults performing a rapid serial visual presentation task. In a dual-condition task, participants had to detect a briefly presented target (T2) after identifying an initial target (T1) embedded in a random series of distractors. A single-condition control task required participants to detect T2 without first identifying T1. The attentional blink (AB) reflects impairments in T2 detection due to the previous identification of T1. Although the amplitude of the AB (difference in T2 detection performance between the single task and the dual task) was found to be similar across age groups, its temporal expression (as a function of the T1–T2 lag) differed across age groups. Our results revealed age-related changes a) in the duration of the first lag(s) sparing effect (longer in the younger age groups), b) in the peak position of the AB (temporal displacement toward later lags in the younger age groups), and c) in the width of the AB (T2 impairments occurring for T1–T2 intervals of 400 ms and 500 ms in 8-year-old children, 300 ms in 10-year-old children, and 200 ms and 300 ms in adults). We discuss these differences in terms of changes in the efficiency of perceptual selection and inhibitory processes (attentional gating mechanisms) during development.
HSP70 binds to speciﬁc non-coding RNA and regulates human RNA polymerase III

Molecular chaperones are critical for protein homeostasis and are implicated in several human pathologies such as neurodegeneration and cancer. While the binding of chaperones to nascent and misfolded proteins has been studied in great detail, the direct interaction between chaperones and RNA has not been systematically investigated. Here, we provide the evidence for widespread interaction between chaperones and RNA in human cells. We show that the major chaperone heat shock protein 70 (HSP70) binds to non-coding RNA transcribed by RNA polymerase III (RNA Pol III) such as tRNA and 5S rRNA. Global chromatin proﬁling revealed that HSP70 binds genomic sites of transcription by RNA Pol III. Detailed biochemical analyses showed that HSP70
A hybrid HW-SW approach for intermittent error mitigation in streaming-based embedded systems

Recent advances in process technology augment the systems-on-chip (SoCs) functionality per unit area with the substantial decrease of device features. However, features abatement triggers new reliability issues such as the single-event multi-bit upset (SMU) failure rates augmentation. To mitigate these failure rates, we propose a novel error mitigation mechanism that relies on a hybrid HW-SW technique. In our proposal, we enforce SoC SRAMs by implementing a fault-tolerant memory buffer with minimal capacity to ensure error-free operation. We utilize this buffer to temporarily store a portion of the stored data, named a data chunk, that is used to restore another data chunk in a fully demand-driven way, in case the latter is faulty. We formulate the buffer and data chunk size selection as an optimization problem that targets energy overhead minimization, given that timing and area overheads are restricted with hard constraints decided beforehand by the system designers. We show that our proposed mitigation scheme achieves full error mitigation in a real SoC platform with an average of 10.1% energy overhead with respect to a base-line system operation, while guaranteeing all the design-time constraints.
Exploratory Examination of Relationships Between Creativity Styles and Creative Products

This study explored the relationship between individuals' styles of creativity and perceptions of the characteristics of their products at work. Kirton's (1976) adaptor-innovator (A—I) theory was used to examine style. Specifically, individuals' perceptions of the A—I style required by their jobs, the style they currently exhibited at work, and their ideal style at work were compared to self-descriptions of their products. Creative product criteria were used to evaluate creative productivity in the workplace. Employees from two British companies were surveyed (ns=59 and 81). Results showed clear and consistent relationships between creativity style and aspects associated with work-related products. The adaptive orientation was linked to products that were described as logical, adequate, well-crafted, and useful. In contrast, the innovative style was highly related to product characteristics such as original, attractive, transformational, and expressive. The practical implications of these findings for ind.
Introduction: Is there a Nordic model in education?

Theoretical journals enjoy a precarious existence at the best of times, never being certain what next year will bring. But the best security they can have for their relevance and their longevity is that they manage to carve out a niche in the theoretical world that they serve. As Åsmund Strømnes, the editor, says in his editorial, it is the intention of this journal to serve educationalists in the Nordic countries by providing a platform in English for their research and to present to the rest of the world theoretical work dealing with the Nordic countries. The international world of learning can turn to this journal for the latest research on education in the Nordic countries expressed in the lingua franca of the present times, the English language. It has a broad sweep and attempts to let the quality of the research guide decisions about publication. The idea behind this jubilee celebration issue is simple. We asked a number of leading researchers in Scandinavia to approach the Nordic systems of education from a number of viewpoints. The intention was to see which characteristics of the Nordic systems are common and which ones are different. It was up to the experts themselves how they conducted their work but each one was asked to concentrate on one area. The five selected areas were: (1) the ideology and structure of the Nordic school system; (2) education as a part of the welfare system past and present; (3) education as a part of the political system; (4) traditions in teaching and future challenges; and (5) problems of assessment and learning outcome. In addition to these themes we asked one contributor to assess Grundtvig’s influence on the school systems and on the Danish system in particular. The results of the work of these authors are to be found in this Jubilee Issue.
Social Networking Effect at "HiWEL" Kiosks amongst Children

Purpose – The purpose of this paper is to study the values of children using Minimally Invasive Education (MIE) kiosks and identify any changes in these values as a result of using the kiosks.Design/methodology/approach – The sample consists of 85 children residing at the Vivekananda Camp. There are 44 boys with an average age of 11.62 years and 41 girls with an average of 11.75 years. Average education level of these children is up to the 8th class. Girls generally stop going to school after the 8th class as they are expected to prepare for marriage. The evaluation is based on the 12 key universal values specified (for children between 8 and 14 years) by the Living Values Educational Program, which are: peace, respect, cooperation, freedom, happiness, honesty, humility, love, responsibility, simplicity, tolerance, and unity. A questionnaire based on the above values is developed. Originally, the questionnaire consisted of 30 situational‐based questions with multiple choices. In the present paper, values .
Optimal Execution of Co-analysis for Large-Scale Molecular Dynamics Simulations

The analysis of scientific simulation data enables scientists to derive insights from their simulations. This analysis of the simulation output can be performed at the same execution site as the simulation using the same resources or can be done at a different site. The optimal output frequency is challenging to decide and is often chosen empirically. We propose a mathematical formulation for choosing the optimal frequency of data transfer for analysis and the feasibility of performing the analysis, under the given resource constraints such as network bandwidth, disk space, available memory, and computation time. We propose formulations for two cases of co-analysis — local and remote. We consider various analyses features such as computation time, input data and memory requirement, importance of the analysis and minimum frequency required for performing the analysis. We demonstrate the effectiveness of our approach using molecular dynamics applications on the Mira and Edison supercomputers.
Minimisation of required charge for desired neuronal spike rate

Retinal implants restore limited visual perception to blind implantees by electrical stimulation of surviving neurons. We consider the efficacy of two electrical stimulation parameters, frequency of stimulation and interphase gap between cathodic and anodic phases, on the required charge to reach a desired neuronal spike rate. Using a Hodgkin-Huxley model of a neuron, we find the most efficient means of achieving a desired spike rate for neurons by electrical stimulation is to use a stimulation frequency identical to the desired spike rate, as well as a long interphase gap.
Angiotensin-Converting Enzyme Inhibition and Endothelin Antagonism for Endothelial Dysfunction in Heart Failure: Mono-or Combination Therapy

The effect of angiotensin-converting enzyme (ACE) inhibition and endothelin A (ETA) receptor antagonism alone and in combination on endothelial vasomotor dysfunction in chronic heart failure (CHF) was compared. Vasoreactivity and superoxide anion formation were determined in aortic rings from Wistar rats with experimental CHF 12 weeks after extensive myocardial infarction compared with sham-operated animals. Rats were treated with placebo, with the ETA receptor antagonist LU 135252 (30 mg/kg/d), with the ACE inhibitor trandolapril (0.3 mg/kg/d), or with a combination of LU 135252 and trandolapril. Infarct size was similar among the groups. In the placebo group, the concentration-response curve of the endothelium-dependent, acetylcholine-induced relaxation was significantly shifted to the right and the maximum relaxation was attenuated (Rmax 53 ± 3%) compared with the sham placebo group (Rmax 72 ± 3%). Treatment with LU 135252 as well as trandolapril significantly improved acetylcholine-induced maximum relaxation (LU 135252 66 ± 4%, trandolapril 67 ± 4%, p < 0.05 versus CHF placebo). In addition to Rmax (LU 135252/trandolapril 70 ± 4%), combination therapy also improved the pathologic rightward shift (p < 0.05). Increased O2− production in CHF was significantly reduced in all treatment groups. The increased relaxation elicited by exogenous superoxide dismutase in CHF was reduced to normal values by monotherapy and further attenuated by combination treatment. Although monotherapy with the ACE inhibitor trandolapril and the ETA receptor antagonist LU 135252 improved endothelial dysfunction in experimental CHF, combination therapy was more effective.
1 STRIVING FOR CONTINUOUS PROCESS IMPROVEMENT IN CONSTRUCTION – A CASE STUDY

Organisations must constantly monitor, measure, evaluate and improve their processes in order to remain competitive. Construction organisations are no different in this aspect and are increasingly realising the need for process improvement due to external and internal pressures. The construction industry is working towards improving its efficiency by implementing process improvement techniques such as Lean Construction along with information and communication systems. Business processes and information technology are closely associated and better results can be achieved by addressing them in an integrated manner. This paper provides details of a case study where an extensive business process improvement exercise was carried out over a period of five years alongside a major Enterprise Information System implementation. All major organisational units were assessed and its processes were modelled and evaluated with a view to improvement within the lean framework. Finally a continuous process improvement framework was put in place to avoid the risk of stagnation. The lean continuous improvement framework resulted in each organisational unit taking responsibility for their own processes ultimately leading to higher profitability and smoother supply chain processes. The case study also demonstrated that even smaller business units and its processes affected the overall value chain in a major way and the importance to analyse the process interdependencies between organisational units.
Telemedicine for rural cancer care in North Queensland: bringing cancer care home.

OBJECTIVE To describe the use of telemedicine in cancer care (teleoncology model of care) for rural patients in North Queensland. DESIGN This is a descriptive study. Data on demographical and clinical factors were retrieved from the teleoncology database of Townsville Hospital and review of medical records for the period between May 2007 and May 2011. SETTING AND PARTICIPANTS The medical oncologists at the Townsville Cancer Centre, a regional cancer centre in North Queensland, have been providing their services to rural hospitals in Townsville and Mt Isa districts via videoconferencing since 2007. INTERVENTION Cancer care delivery to rural sites via Townsville teleoncology model. MAIN OUTCOME MEASURES The ability of the teleoncology model to provide the following services to rural towns: (i) specialist consultations; (ii) urgent specialist medical care; (iii) care for Indigenous patients; and (iv) remote supervision of chemotherapy administration. RESULTS Between May 2007 and May 2011, 158 patients from 18 rural towns received a total of 745 consultations. Ten of these patients were consulted urgently and treatment plans initiated locally, avoiding interhospital transfers. Eighteen Indigenous patients received consultative services, being accompanied by more than four to six family members. Eighty-three patients received a range of intravenous and oral chemotherapy regimens in Mt Isa and oral agents in other towns through remote supervision by medical oncologists from Townsville. CONCLUSION Teleoncology model of care allows rural and Indigenous cancer patients to receive specialist consultations and chemotherapy treatments closer to home, thus minimising the access difficulties faced by the rural sector.
Annals of the New York Academy of Sciences the Neuroevolution of Empathy

There is strong evidence that empathy has deep evolutionary, biochemical, and neurological underpinnings. Even the most advanced forms of empathy in humans are built on more basic forms and remain connected to core mechanisms associated with affective communication, social attachment, and parental care. Social neuroscience has begun to examine the neurobiological mechanisms that instantiate empathy, especially in response to signals of distress and pain, and how certain dispositional and contextual moderators modulate its experience. Functional neuroimaging studies document a circuit that responds to the perception of others' distress. Activation of this circuit reflects an aversive response in the observer, and this information may act as a trigger to inhibit aggression or prompt motivation to help. Moreover, empathy in humans is assisted by other domain-general high-level cognitive abilities, such as executive functions, mentalizing, and language, which expand the range of behaviors that can be driven by empathy.
Current State of Knowledge: Psychosocial Development in Children with Hearing Impairment

The purpose of this review is to synthesize historical and recent evidence concerning psychosocial development in children with mild to severe hearing impairment. Included are studies of quality of life, social-emotional development, self-concept, and social access. Concerns are raised about sampling issues and limited consistency in measurement strategies used. Interdisciplinary perspectives on social-emotional learning and development are integrated in an effort to identify research gaps and suggest future research needs. The need for prospective studies involving a new generation of children with early access to amplification is stressed.
Characterization of bioactive compounds contained in vegetables of the Solanaceae family by capillary electrophoresis

Because of their antioxidative capability polyphenols and vitamins are the most important naturally occurring compounds. Several widely consumed vegetables are rich in various phenolic compounds and vitamins. In this study, such vegetables as tomato ( Solanum lyco- persicum), eggplant (Solanum melongena), chilli pepper ( Capsicum annuum), and potato (Solanum tuberosum) of the Solanaceae family were investigated. The phenolic com pounds and vitamins were separated and their composition was determined by capillary electrophoresis (CE). The total phenolic content was measured according to the Price and Butler met hod. In addition, the antioxidative capability of phenolic compounds was monitored and evaluated by CE using a coloured free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH).
A Formal Analysis of the Model Preliminaries

This appendix has three parts. §A contains formal analysis and proofs for the model. Additional results are also derived. §B describes our methodology for identifying eponymous firms, and shows our results are robust to alternative methods. §C contains additional empirical results and robustness checks. §A Formal Analysis of the Model Preliminaries We note three properties of the sender's expected payo↵ function, u ✓ : i) u ✓ is di↵erentiable in both of its arguments; ii) @u ✓ @µ > 0; iii) u H (s, µ) u L (s, µ) for any (s, µ), and the inequality is strict if and only if µ 2 (0, 1). Property (i) is immediate. To see (ii), let V 1 , V 2 be the sender's first-and second-period payo↵ functions, respectively. Note that u H (s, µ 1) = V 1 (µ 1) + pV 2 (s, µ 2 (µ 1 , h)) + (1 p)V (s, µ 2 (µ 1 , l)). Therefore, @u H @µ 1 = @V 1 @µ 1 + p @V 2 @µ 2 @µ 2 (µ 1 , h) @µ 1 + (1 p) @V 2 @µ 2 @µ 2 (µ 1 , l) @µ 1. Using the expressions for V 1 , V 2 , and Bayes rule for µ 2 , we get @V 1 @µ 1 = 2p 1 > 0, @µ 2 (µ 1 , h) @µ 1 = (1 p)p (1 p µ 1 + 2pµ 1) 2 > 0, @V 2 @µ 2 = s(1 +) > 0, @µ 2 (µ 1 , l) @µ 1 = (1 p)p (p + µ 1 2pµ 1) 2 > 0, which imply the result when ✓ = H. A symmetric argument holds for ✓ = L. For (iii), see that u H (s, µ 1) u L (s, µ 1) = (2p 1) V 2 (s, µ 2 (µ 1 , h)) V 2 (s, µ 2 (µ 1 , l)) = (1 +)(1 2p) 2 s(1 µ 1)µ 1 µ 1 µ 2 1 + (p p 2) (2µ 1 1) 2. It is clear that the numerator is positive for all µ 1 2 (0, 1) and zero when µ 1 = 0, 1. Because p 2 (1 2 , 1), the detonator is positive for all µ 1 2 [0, 1], giving the result.
A Coreference Service for Enterprise Application Integration using Linked Data

The use of semantic and Linked Data technologies for Enterprise Application Integration (EAI) is increasing in recent years. Linked Data and Semantic Web technologies such as the Resource Description Framework (RDF) data model provide several key advantages over the current de-facto Web Service and XML based integration approaches. The flexibility provided by representing the data in a more versatile RDF model using ontologies enables avoiding complex schema transformations and makes data more accessible using Web standards, preventing the formation of data silos. These three benefits represent an edge for Linked Data-based EAI. However, work still has to be performed so that these technologies can cope with the particularities of the EAI scenarios in different terms, such as data control, ownership, consistency, or accuracy. The first part of the paper provides an introduction to Enterprise Application Integration using Linked Data and the requirements imposed by EAI to Linked Data technologies focusing on one of the problems that arise in this scenario, the coreference problem, and presents a coreference service that supports the use of Linked Data in EAI systems. The proposed solution introduces the use of a context that aggregates a set of related identities and mappings from the identities to different resources that reside in distinct applications and provide different views or aspects of the same entity. A detailed architecture of the Coreference Service is presented explaining how it can be used to manage the contexts, identities, resources, and applications which they relate to. The paper shows how the proposed service can be utilized in an EAI scenario using an example involving a dashboard that integrates data from different systems and the proposed workflow for registering and resolving identities. As most enterprise applications are driven by business processes and involve legacy data, the proposed approach can be easily incorporated into enterprise applications.
Analog memristive and memcapacitive properties of Ti / AI2O3 / Nb2O5 / Ti resistive switches

Versatile resistance switching effects in niobium oxide based MIM structures have been reported. Besides the filamentary resistance and threshold switching effects, which occur after an initial electroforming process, a forming free resistance switching operation was found in a double layer structure of Nb2O5 and Al2O3. In our work we report on the co-existence of a capacitance change accompanying the analog resistance switching effect. This memcapacitive effect might enable new applications in analog circuits, which go beyond the pure data storage. Results of IV-and CV characterization as well as impedance spectroscopy are presented. Furthermore, a physical model is proposed which describes the underlying mechanisms as interfacial quantum mechanical effect based on charging and discharging of electron trap states.