Miracle-dz/UniFAR-FTUs huggingface dataset:
Pneumonia following antipsychotic prescriptions in electronic health records: a patient safety concern?

BACKGROUND In screening the Intercontinental Medical Statistics (IMS) Health Disease Analyzer database of GP records from the UK, an increased registration of pneumonia subsequent to the prescription of some antipsychotic medicines was identified. AIM To investigate the temporal pattern between antipsychotic prescriptions and pneumonia with respect to age, type of pneumonia and other chest infections, and antipsychotic class. DESIGN OF STUDY Self-controlled cohort analysis. SETTING Electronic health records from the UK IMS Health Disease Analyzer database. METHOD Three groups of pneumonia-related International Classification of Diseases (ICD)-10 terms and prescriptions of atypical and conventional antipsychotic medicines were studied. Separate analyses were carried out for patients aged 65 years. The observed rate of pneumonia terms registered in different time periods in connection to antipsychotic prescriptions was contrasted to the overall rate of pneumonia terms relative to prescriptions of other drugs in the same dataset. RESULTS In patients aged ≥ 65 years, an increased registration of a group of terms defined as 'acute chest infections', after atypical antipsychotic prescriptions, was identified. The corresponding increase after conventional antipsychotic prescriptions was much smaller. Bronchopneumonia had a striking increase after both atypical and conventional antipsychotic prescriptions, and was commonly recorded with fatal outcome. Few registrations of hypostatic pneumonia were noted. Patients aged <65 years did not have a higher rate of acute chest infections after receiving antipsychotic prescriptions. CONCLUSION The consistent pattern of an increased rate of chest infections after atypical antipsychotic prescriptions in older people seen in this outpatient study, together with the higher risk shown in a previous study on hospitalised patients, suggests a causal relationship. This is of importance since bronchopneumonia seems highly linked to fatal outcome. In the absence of a mechanism, further investigation of the role of antipsychotics in older people is needed.
Relations of Parents' Beliefs to Children's Motivation in an Elementary Physical Education Running Program

Using achievement goal theory and the expectancy-value model of achievement choice as theoretical frameworks, this study examined relationships between parents’ beliefs and their children’s motivation in an elementary physical education running program. Participants included 102 parents and their children (49 boys; 53 girls) in the third and fourth grades. The parents completed questionnaires assessing their achievement goals, competence beliefs, task values, and gender stereotypic beliefs about running. Children’s persistence/effort was assessed by the number of laps run/walked over the year-long running program. Performance was measured by the timed mile run. Results indicated that only parents’ competence/value beliefs were predictive of their children’s persistence/effort and mile run performance. Gender stereotypic beliefs influenced achievement goals the parents adopted for their children. Findings provided empirical support for the importance of parental beliefs for children’s motivation in physica.
Inhibition of Caffeine Rigor and Radiocalcium Movements by Local Anesthetics in Frog Sartorius Muscle

Local anesthetics have been found to act as competitive inhibitors of caffeine in frog sartorius muscle. They block caffeine-induced rigor and the attendant increase in Ca45 influx and efflux. Increased net uptake of sodium, loss of potassium, and concurrent increase in oxygen consumption are all effectively blocked by procaine. Evidence is presented that the inhibitory effect of the local anesthetics cannot be explained by the formation of molecular complexes with caffeine. Increased efflux of Ca45 produced by changing from zero calcium Ringer's to 0.1 mM or 1 mM calcium Ringer's is inhibited by procaine and tetracaine. EDTA-stimulated calcium efflux is not affected by either local anesthetic. Caffeine rigor develops in frog muscle depolarized with KCl or rendered electrically inexcitable by sodium lack. Both the rigor and the increased calcium fluxes are inhibited by local anesthetics in depolarized muscle.
Feature fusion at the local region using localized maximum-margin learning for scene categorization

In the ﬁeld of visual recognition such as scene categorization, representing an image based on the local feature (e.g. the bags of visual words (BOW) model and its variants) has become popular and one of the most successful method-s. In this paper, we propose a method that uses localized maximum-margin learning to fuse diﬀerent types of features during the BOW modeling process for eventual scene classiﬁcation. Unlike previous feature fusion methods for visual recognition, which combines the features after generating the entire set of representations based on diﬀerent types of features from local regions, the proposed method fuses diﬀerent features at the stage when the best visual word is selected to represent a local region (hard assignment) or the probabilities of the candidate visual words used to represent the unknown region are estimated (soft assignment). The merits of the proposed method are that (1) errors caused by the ambiguity of single feature when assigning local regions to the best representative visual words can be corrected or the probabilities of the candidate visual words used to represent the region can be estimated more accurately; and that (2) it oﬀers a more ﬂexible way in fusing these features through determining the similarity-metric locally by localized maximum-margin learning. The proposed method has been evaluated experimentally and the results indicate its eﬀectiveness.
The Reproducibility of a Kinematically-Derived Axis of the Knee versus Digitized Anatomical Landmarks using a Knee Navigation System

Component position is critical to longevity of knee arthroplasties. Femoral component rotation is typically referenced from the transepicondylar axis (TEA), the anterior-posterior (AP) axis or the posterior condylar axis. Other studies have shown high variability in locating the TEA while proposing digitization of other landmarks such as the AP axis as a less-variable reference. This study uses a navigation system to compare the reproducibility of computing a kinematically-derived, navigated knee axis (NKA) to digitizing the TEA and AP axis. Twelve knees from unembalmed cadavers were tested. Four arthroplasty surgeons digitized the femoral epicondyles and the AP axis direction as well as flexed and extended the knee repeatedly to allow for NKA determination. The variance of the NKA axis determined under neutral loading conditions was smaller than the variance of the TEA axis when the kinematics were measured in the closed surgical condition (P<0.001). However, varus, valgus, and internal loading of the leg increased the variability of the NKA. Distraction of the leg during knee flexion and extension preserved the low variability of the NKA. In conclusion, a kinematically-derived NKA under neutral or distraction loading is more reproducible than the TEA and AP axis determined by digitization.
Posterior Subtenon Triamcinolone Acetonide in Gas-filled Eyes as an Adjunctive Treatment for Complicated Proliferative Diabetic Retinopathy

Purpose To evaluate the effect of adjunctive subtenon injection of triamcinolone acetonide (TA) in gas-filled eyes after vitrectomy for complicated proliferative diabetic retinopathy (PDR). Methods This nonrandomized comparative study included 27 patients (27 eyes) who underwent pars plana vitrectomy and gas tamponade for treatment of PDR with tractional or combined tractional-rhegmatogenous retinal detachment and who received subtenon injection of TA (40 mg) at the end of surgery. The study group was compared with the control group (29 eyes), which was matched with the study group for preoperative and intraoperative parameters, but underwent pars plana vitrectomy and gas tamponade without a subtenon injection of TA. Results Retinal reattachments without reoperation were achieved in 25 eyes (92.6%) and 26 eyes (89.7%) at 6 months (p = 1.000) in the study and control groups, respectively. The study group and the control group did not differ significantly in the frequency of postoperative proliferative vitreoretinopathy, retinal redetachment rate, reoperation rate, macular pucker formation, postoperative vitreous hemorrhage, gain in visual acuity, intraocular pressure, and intraocular inflammation (p > 0.05). Conclusions The clinical results of pars plana vitrectomy for complicated PDR are not improved significantly by an adjunctive subtenon TA injection in gas-filled eyes.
Necesidades educativas específicas del alumnado con altas capacidades en relación con la creatividad

espanolEn la literatura especializada se subraya la importancia de la creatividad en el alumnado de altas capacidades y con frecuencia se determina como un criterio basico para el diagnostico de la superdotacion. Sin, embargo, a pesar de esta aparente unanimidad a la hora de considerar la creatividad como un elemento clave dentro de la educacion de este tipo de estudiantes, existen numerosas limitaciones que rodean el trabajo en este campo: desde una incompleta comprension del termino “creatividad”; pasando por las frecuentes dificultades para poder evaluarla de forma fiable; hasta la que se esta convirtiendo en la mayor dificultad saber cual es la manera correcta de intervenir para cubrir y desarrollar esta capacidad dentro de la escuela. La creatividad puede y debe ser desarrollada a traves del proceso educativo para poder favorecer las potencialidades individuales de las personas con altas capacidades. Educar en la creatividad es una prioridad de la ensenanza dirigida a los estudiantes superdotados que les permitira prepararse mejor para el cambio, ser mas flexibles, con mayor iniciativa y autoconfianza, mas capaces de afrontar los obstaculos y, sobretodo, mas habiles en el uso de su capacidad de innovacion. EnglishIn the literature emphasizes the importance of creativity in students of high ability and is often determined as a basic criterion for the diagnosis of giftedness. Sin, however, despite this apparent unanimity in considering creativity as a key element in the education of such students, there are many constraints surrounding the work in this field: since an incomplete understanding of the term “creativity “going through the frequent difficulties to reliably assess, until the which is becoming the greatest difficulty, to know the right way to intervene to meet and develop this capacity within the school. Creativity can and should be developed through the educational process to encourage individual potential of people with high ability. Educating for creativity is a priority of education aimed at gifted students allowing them to better prepare for change, be more flexible, have more initiative and self-confidence, more capable of addressing the barriers and, above all, more skillful in using their innovative capacity
Restoration of Degraded Images for Text Detection and Recognition

The task of text detection natural scene images is very challenging due to the complex background and unpredictable text appearances in the image. Apart from the background and the structure of the text, unpredictability also lies in the image capturing quality. These issues include noise, orientation, low exposure, blurring, and other kinds of degradations. It is therefore necessary to first restore the target text in the image in order to ensure robust text detection and recognition. This research focuses on removing a maximum number of degradation factors from a natural scene image containing text such that the detection and recognition of the text present in that image becomes very easy. Text Specific Dictionaries will be used in order to restore the text in the images. The sparse representation method is selected with an aim to apply techniques such as denoising, deblurring, sharpening and implementing other forms of enhancement in a single text image restoration system. General Terms Image restoration, Image enhancement, Text Detection, Text recognition, Sparse representations, Dictionaries.
A Century of Debt Crises in Latin America: From Independence to the Great Depression@@@Debt and Democracy in Latin America@@@Lost Promises: Debt, Austerity, and Development in Latin America

A Century of Debt Crises in Latin America: From Independence to the Great Depression. By Carlos Marichal. Princeton: Princeton University Press, 1989. 283p. $45.00 cloth, $16.50 paper. Debt and Democracy in Latin America. Edited by Barbara Stallings and Robert Kaufman. Boulder: Westview, 1989. 232p. $29.00 cloth, $14.95 paper. Lost Promises: Debt, Austerity, and Development in Latin America. Edited by William L. Canak. Boulder: Westview, 1989. 244p. $37.00 cloth, $16.00 paper.
Isolation and characterization of a proteinaceous subnuclear fraction composed of nuclear matrix, peripheral lamina, and nuclear pore complexes from embryos of Drosophila melanogaster

Morphologically intact nuclei have been prepared from embryos of Drosophila melanogaster by a simple and rapid procedure. These nuclei have been further treated with high concentrations of DNase I and RNase A followed by sequential extraction with 2% Triton X-100 and 1 M NaCl to produce a structurally and biochemically distinct preparation designated Drosophila subnuclear fraction I (DSNF-I). As seen by phase- contrast microscopy, DSNF-I is composed of material which closely resembles unfractionated nuclei; residual internal nuclear structures including nucleolar remnants are clearly visible. By transmission electron microscopy, nuclear lamina, pore complexes, and a nuclear matrix are similarly identified. Biochemically, DSNF-I is composed almost entirely of protein (greater than 93%). SDS PAGE analysis reveals several major polypeptides; species at 174,000, 74,000, and 42,000 predominate. A polypeptide coincident with the Coomassie Blue- stainable 174-kdalton band has been shown by a novel technique of lectin affinity labeling to be a glycoprotein; a glycoprotein of similar or identical molecular weight has been found to be a component of nuclear envelope fractions isolated from the livers of rats, guinea pigs, opossums, and chickens. Antisera against several of the polypeptides in DSNF-I have been obtained from rabbits, and all of them show only little or no cross-reactivity with Drosophila cytoplasmic fractions. Initial results of immunocytochemical studies, while failing to positively localize either the 174- or 16-kdalton polypeptides, demonstrate a nuclear localization of the 74-kdalton antigen in all of several interphase cell types obtained from both Drosophila embryos and third-instar larvae.
Recombinant human thyrotropin-stimulated radioiodine therapy of nodular goiter allows major reduction of the radiation burden with retained efficacy.

CONTEXT AND OBJECTIVE Stimulation with recombinant human TSH (rhTSH) before radioiodine (131I) therapy augments goiter volume reduction (GVR). Observations indicate that rhTSH has a preconditioning effect beyond increasing thyroid (131)I uptake. We test the hypothesis that an equivalent GVR might be obtained by an absorbed thyroid dose well below what has been used previously. PATIENTS AND DESIGN In a double-blinded setup, 90 patients (78 women; median age, 52 yr; range, 22-83) with a nontoxic nodular goiter (median size, 63 ml; range, 25-379 ml) were randomized to either 0.1 mg rhTSH (n=60) followed by a thyroid dose of 50 Gy or placebo followed by 100 Gy (n=30). RESULTS At 12 months, the mean relative GVR in the placebo and the rhTSH group was identical (35+/-3%; P=0.81). The median administered 131I-activity was 170 MBq (45-1269) in the rhTSH group and 559 MBq (245-3530) in the placebo group (70% reduction, P<0.0001). According to the official radiation regulation, hospitalization was required in 14 patients in the placebo group vs. one patient in the rhTSH group (P<0.0001). In both groups, goiter-related symptoms were effectively relieved in the majority of patients. The prevalence of myxedema (10%) did not differ among groups. CONCLUSIONS This is the first study to demonstrate that rhTSH not only increases the thyroid 131I uptake, but per se potentiates the effect of 131I-therapy, allowing a major reduction of the 131I-activity without compromising efficacy. This approach is attractive in terms of minimizing posttherapeutic restrictions and in reducing the potential risk of radiation-induced malignancy.
Security Model to Incorporate AddOn Security for Business Services

Nowadays, the services offered by the Service Providers are subjected to many risks in terms of privacy agreements and hence they are treated as untrustworthy. Security risk analysis is fundamental to the security of any business and it is considered to be very essential in ensuring that controls and expenditure are fully commensurate with the risks to which the business is exposed. Hence, the Customer requires a set of security services and the model driven security specifications in terms of security policies such as authentication, authorization, confidentiality, integrity and audit in order to overcome such situations. The Customer security requirements should match with the security specifications that are recommended or delivered by the Service Provider and these contracts can be done through Service Level Agreements. In our paper we propose an Add-on security model which provides interoperable security services for the business services according to the security requirements of the business. We also establish the model as schema driven security model which facilitate dynamic integration of security services with the associated business services and finally to provide security assessment and verification mechanism for the Add-on security services along with the business requirements. The security assessment and verification is done automatically using Add-on security service assessment model. This issue plays a main role in verifying where the security model matches with the business requirements and also whether the security agreements are well maintained by both consumer and the service provider. We convert source code to first order logic in reasoning engine to evaluate the policy rules that influence the subject, resource and environment to determine the Access point in the security services and also finally evaluating the QOS like cost, response time, execution time and uptime for business services along with Add-on security features.
Current V3 genotyping algorithms are inadequate for predicting X4 co-receptor usage in clinical isolates

Objective:Integrating CCR5 antagonists into clinical practice would benefit from accurate assays of co-receptor usage (CCR5 versus CXCR4) with fast turnaround and low cost. Design:Published HIV V3-loop based predictors of co-receptor usage were compared with actual phenotypic tropism results in a large cohort of antiretroviral naive individuals to determine accuracy on clinical samples and identify areas for improvement. Methods:Aligned HIV envelope V3 loop sequences (n = 977), derived by bulk sequencing were analyzed by six methods: the 11/25 rule; a neural network (NN), two support vector machines, and two subtype-B position specific scoring matrices (PSSM). Co-receptor phenotype results (Trofile Co-receptor Phenotype Assay; Monogram Biosciences) were stratified by CXCR4 relative light unit (RLU) readout and CD4 cell count. Results:Co-receptor phenotype was available for 920 clinical samples with V3 genotypes having fewer than seven amino acid mixtures (n = 769 R5; n = 151 X4-capable). Sensitivity and specificity for predicting X4 capacity were evaluated for the 11/25 rule (30% sensitivity/93% specificity), NN (44%/88%), PSSM(sinsi) (34%/96%), PSSM(x4r5) (24%/97%), SVMgenomiac (22%/90%) and SVMgeno2pheno (50%/89%). Quantitative increases in sensitivity could be obtained by optimizing the cut-off for methods with continuous output (PSSM methods), and/or integrating clinical data (CD4%). Sensitivity was directly proportional to strength of X4 signal in the phenotype assay (P < 0.05). Conclusions:Current default implementations of co-receptor prediction algorithms are inadequate for predicting HIV X4 co-receptor usage in clinical samples, particularly those X4 phenotypes with low CXCR4 RLU signals. Significant improvements can be made to genotypic predictors, including training on clinical samples, using additional data to improve predictions and optimizing cutoffs and increasing genotype sensitivity.
SmartMATE : Online Self-Serve Access to State-ofthe-Art SMT

Access to good quality Machine Translation (MT) has never been as easy as it is today. Portals such as Google Translate and Bing Translator facilitate huge amounts of translation requests on a daily basis, for an ever increasing spectrum of language pairs. People are finding many uses for the raw MT output provided by these, and other, freely available engines on the web, including gisting, assimilation, first drafts of translations for dissemination, etc. However, each of these systems is a ’one-size-fits-all’ solution, where no customization is available to the user. One alternative is to purchase a system, which may be overly expensive, or sub-optimal for the type of documentation required to be translated. Another alternative is to install a freely available system such as Moses, but this may prove unduly onerous for the naı̈ve user. In this paper, we present a portal which facilitates selfserve MT using state-of-the-art statistical MT (SMT). This is currently free for anyone to access and personalise their system by uploading their own Translation Memory(TM) and glossaries. By means of a simple key-press, optimal training, development and test data are created on-thefly, which are then used for an automatic system build, with the results published in very acceptable amounts of time, together with automatic evaluation scores. According to user trials, this – together with builtin TM and online editing functionality – is a very exciting development, with the potential to vastly expand the user-base for self-serve SMT on a global basis.
In Vivo Interaction between NPR1 and Transcription Factor TGA2 Leads to Salicylic Acid–Mediated Gene Activation in Arabidopsis Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.001628.

The Arabidopsis NPR1 protein is a key regulator of salicylic acid (SA)–mediated gene expression in systemic acquired resistance. Based on yeast two-hybrid analysis, NPR1 has been suggested to interact with members of the TGA family of transcription factors, including TGA2 (AHBP-1b). However, genetic evidence demonstrating that the NPR1–TGA interaction occurs in planta is still lacking, and the role of this interaction in SA-mediated gene activation has yet to be determined. In this study, we expressed a truncated form of TGA2 in Arabidopsis and found that the resulting transgenic lines displayed phenotypes similar to those of npr1 mutants. This dominant-negative effect of the TGA2 mutant shows that TGA2 and NPR1 interact in planta. We also present biochemical evidence indicating that this interaction is specific and enhanced by SA treatment. Moreover, using a chimera reporter system, we found that a chimeric TGA2GAL4 transcription factor activated a UASGAL::GUS reporter gene in response to SA and that this activation was abolished in the npr1 mutant. NPR1 is required for the DNA binding activity of the transcription factor. These genetic data clearly demonstrate that TGA2 is a SA-responsive and NPR1-dependent transcription activator.