Miracle-dz/UniFAR-FTUs huggingface dataset:
Implementing Iterative Algorithms with SPARQL

The SPARQL declarative query language includes innovative capabilities to match subgraph patterns within a semantic graph database, providing a powerful base upon which to implement complex graph algorithms for very large data. Iterative algorithms are useful in a wide variety of domains, in particular in the data-mining and machine-learning domains relevant to graph analytics. In this paper we describe a general mechanism for implementing iterative algorithms via SPARQL queries, illustrate that mechanism with implementation of three algorithms (peer-pressure clustering, graph di↵usion, and label propagation) that are valuable for graph analytics, and observe the strengths and weaknesses of this approach. We find that writing iterative algorithms in this style is straightforward to implement, with scalability to very large data and good performance.
Glucagon and Related Peptides. Molecular Structure and Biological Specificity a

OThe work of the authors included in this review was supported by INSERM (CRL 79 5 449 7 and 82 7 009), CNRS, Swedish MRC (MFR K75 60F 4896 and B81 13F 60044 O l ) , European Economic Community (85 1OOOOOI BE02 PUJU l), and the Fonds pour la Recherche M6dicale. bThis peptide terminology uses the one-letter code4' of the first and last amino acids followed by the number of amino acids. In this terminology, glucagon would be HT-29, oxyntomodulin
Dermal Contributions to Human Interfollicular Epidermal Architecture and Self-Renewal

The human interfollicular epidermis is renewed throughout life by populations of proliferating basal keratinocytes. Though interfollicular keratinocyte stem cells have been identified, it is not known how self-renewal in this compartment is spatially organized. At the epidermal-dermal junction, keratinocytes sit atop a heterogeneous mix of dermal cells that may regulate keratinocyte self-renewal by influencing local tissue architecture and signalling microenvironments. Focusing on the rete ridges and complementary dermal papillae in human skin, we review the identity and organisation of abundant dermal cells types and present evidence for interactions between the dermal microenvironment and the interfollicular keratinocytes.
The theory of reasoned action and problem-focused research

(From the chapter) review some recent criticisms of TRA [theory of reasoned action] / suggest how they may best be dealt with by researchers interested in safer sex / this chapter is written from within the framework of psychological theories of decision-making and attitude-behaviour relations / examine the theoretical structure of TRA / examine the variables in TRA in the light of current literature on attitudes and social cognition / turn briefly to the metatheoretical underpinning of the TRA action / [examine] the explicit and implicit assumptions made by TRA and whether they are warranted / examine [the concepts of beliefs, attitudes, norms, intentions, and behaviour] in the context of research on safer sex and HIV-preventive behaviour.
Ambiguity Preserving Machine Translation using Packed Representations

In this paper we present an ambiguity preserving translation approach which transfers ambiguous LFG f-structure representatios. It is based on packed f-structure representations which are the result of potentially ambiguous utterances. If the ambiguities between source and target language can be preserved, no unpacking during transfer is necessary and the generator may produce utterances which maximally cover the underlying ambiguities. We convert the packed f-structure descriptions into a flat set of prolog terms which consist of predicates, their predicate argument structure and additional attribute-value information. Ambiguity is expressed via local disjunctions. The flat representations facilitate the application of a Shake-and-Bake like transfer approach extended to deal with packed ambiguites.
A Nutritional Approach to Managing Exercise-Induced Asthma

Exercise-induced asthma (EIA) is traditionally treated with the use of pharmacotherapy. However, there is now convincing evidence that a variety of dietary factors such as elevated omega-3 polyunsaturated fatty acids and antioxidant intake, and a sodium-restricted diet can reduce this condition. New therapies that are safe, effective, and likely to be used by individuals with EIA are needed.
Analysis of a Botnet Takeover

Botnets, networks of malware-infected machines (bots) that are controlled by an adversary, are the root cause of a large number of security problems on the Internet. A particularly sophisticated and insidious type of bot is Torpig, a malware program designed to harvest sensitive information (such as bank account and credit-card data) from its victims. In this article, the authors report on their efforts to take control of the Torpig botnet and study its operations for a period of 10 days. During this time, they observed more than 180,000 infections and recorded almost 70 Gbytes of data that the bots collected. They also report on what happened in the year that has passed since they lost control of the Torpig botnet.
Parallel FFT with CORDIC for ultra wide band

In this paper, the architecture of a complex 128-point FFT processor using parallel and rolling back structure is presented. The FFT VLSI implementation is suitable to ultra wide band (UWB) communication, because it is ensuring data speed greater than 538 Mbps. With the new VLSI technology, the fast speed and low power are also achieved. The FFT can be operated at an even high frequency up to 200 MHz with FPGA while the power consumption is very low (only for 109 mW at 132 MHz). With 4 radix-4 FFT processors, we employ 16 parallel channels to lower down the operation clock to 132 MHz with the input data of 538 MHz. The CORDIC twiddles processor is applied to combat the area and speed problem compared to a multiplier, so that FFT only has 53 K equivalent gates without sacrificing the data processing speed and throughput.
Staff Emolument Problems/Job Satisfaction And Depression Among Public Servants In Cross River State, Nigeria.

This study was carried out to establish the relationship between emolument and job satisfaction as potent factor in explaining the incident of depression among public servants in Cross River State, Nigeria. The study adopted the ex-post facto design. The sample consisted of 500 (429 males and 71 females) public servants who were randomly selected from state ministries, schools, board and parastatals in the state. A Public Servant Opinion Questionnaire (PSOQ) constructed by the researcher was used for data collection. Two null hypotheses were tested in the study using the Pearson Product Moment Correlation Coefficient. The major findings indicated that staff emolument problem and job satisfaction significantly led to some degree of depression. Based on this result it was concluded that emolument and job satisfaction were significant factors in explaining the incidence of depression. The major recommendations are that depressed people should be referred to seek the services of social psychologist, clinical psychologists in psychiatric hospitals, and also that government/sectors should help in providing good conditions for her staff. Keywords: staff emolument, job satisfaction, depression
Temperature-sensitive polymer-gold nanocomposites as intelligent therapeutic systems

Research in the field of biomaterials and drug delivery is moving toward individually tailored intelligent therapeutic systems which are capable of responding to and correcting undesirable conditions, on a molecular level, within the body (1, 2). These systems will mimic natural biosystems in their size, structure, and function, and will therefore need to be synthesized using advanced nanofabrication techniques. The development of these and other nanoscale polymer systems is of interest in modern research as well, due to the possibility of combining the advantages of traditional macroscale polymer properties, such as swelling, with nanoscale properties, such as faster drug release rates due to shorter characteristic lengths and spatially localized heating effects. Also, due to the size limitations imposed by the body’s natural defense mechanisms, such as the reticuloendothelial system, polymer systems 0.3 μm in diameter and smaller will be required for the development of effective in vivo intelligent therapeutic systems (3-5).
Improving Structural Superpositions for Complex Protein Structures by Limiting Query to Single Domains

Introduction One limitation in deriving biologically significant information from structural superpositions is the large number of false positives resulting from alignments of small portions of the overall structures of functionally unrelated proteins. This weakness could be addresses by requiring that a reported hit and the query be superimposable over most points within each structure. For example, two proteins of high sequence identity (>80%) would be virtually superimposable. However, such a stringent algorithm would fail to report structural homology in the case where two protein structures share a common domain, but differ at other domains in their respective structures. For example, imagine there are two hypothetical transcription factors, TFA and TFB. Both transcription factors bear the same DNA-binding domain (e.g. a helix-turn-helix motif). Yet, their activation domains differ, TFA having a domain that binds another protein and TFB having a domain that binds a steroid. The structural superposition algorithm should be able to identify these two structures as similar. Current algorithms, such as DALI (distance alignment tool) (Holm and Sander, 1993), are capable of doing this. Unfortunately, algorithms that can recognize alignment of single domains will necessarily also report alignments of smaller superpositions, e.g. the alignment of a few helices that bear no more than a structural role. Thus, the number of reported hits can reach into the hundreds. Sorting through all these for true positives is extremely time consuming, especially considering the search may not provide any new information (i.e. all true positives from the search had previously been recognized as structural homologs of the query). What is needed to resolve this difficulty is a method to enrich for hits to a particular portion of the query structure. One approach would be to parse the query structural file into separate files for each domain of the protein of interest, and use these individual files as queries for structural homolog searches. In this paper, I report the results from application of this method to four, 2 domain structures and the poliovirus RNA-dependent RNA polymerase.
Microscopic structure and thermodynamics of a core-softened model fluid from the second-order integral equations theory

We have studied the structure and thermodynamic properties of isotropic three-dimensional core-softened fluid by using the second-order Ornstein-Zernike integral equations completed by the hypernetted chain and Percus-Yevick closures. The radial distribution functions are compared with those from singlet integral equations and with computer simulation data. The limits of the region of density anomaly resulting from different approximate theories are established. The obtained results show that the second-order hypernetted chain approximation can be used to describe both the structure and the density anomaly of this model fluid. Moreover, we present the results of calculations of the bridge functions.
Characterization of the imprinting signature of mouse embryo fibroblasts by RNA deep sequencing

Mouse embryo fibroblasts (MEFs) are convenient sources for biochemical studies when cell number in mouse embryos is limiting. To derive the imprinting signature of MEFs and potentially detect novel imprinted genes we performed strand- and allele-specific RNA deep sequencing. We used sequenom allelotyping in embryo and adult organs to verify parental allele-specific expression. Thirty-two known ubiquitously imprinted genes displayed correct parental allele-specific transcripts in MEFs. Our analysis did not reveal any novel imprinted genes, but detected extended parental allele-specific transcripts in several known imprinted domains: maternal allele-specific transcripts downstream of Grb10 and downstream of Meg3, Rtl1as and Rian in the Dlk1-Dio3 cluster, an imprinted domain implicated in development and pluripotency. We detected paternal allele-specific transcripts downstream of Nespas, Peg3, Peg12 and Snurf/Snrpn. These imprinted transcript extensions were not unique to MEFs, but were also present in other somatic cells. The 5′ end points of the imprinted transcript extensions did not carry opposing chromatin marks or parental allele-specific DNA methylation, suggesting that their parental allele-specific transcription is under the control of the extended imprinted genes. Based on the imprinting signature of MEFs, these cells provide valid models for understanding the biochemical aspects of genomic imprinting.
Confessions of an Aspergic Professor

"Computers were made by and for people with Asperger's Syndrome," goes the joke - but one with a grain of truth. "Academic life suits Aspies" goes another - but is it still true? I was diagnosed with Asperger's Syndrome in 2003, though I had it most of his life, unknown. On discovering this, my wife, Ruth, and I began to understand many of the difficulties I had had. Especially in the academic life of today. The purpose of this post, is to help us understand when academics exhibit Asperger's Syndrome. We usually see A.S. as a disability, but can also view it as a gift. It can be especially helpful when innovation is needed in academic or business life, but is often misunderstood. The post begins with a poem. I am Professor of Human Factors and Philosophy in Information Systems - a rather long title that perhaps speaks of my aspergic attention to wide-ranging detail, of which more below. I teach on a number of programmes including Business Information Technology and supervise a number of MSc and PhD students. Asperger syndrome is a form of autism, which is a lifelong disability that affects how a person makes sense of the world, processes information and relates to other people, this short animation from the National Autism Society outlines some of the generic points:
Epigenetics and Chromatin Remodeling Play a Role in Lung Disease

Epigenetics is defined as heritable changes that affect gene expression without altering the DNA sequence. Epigenetic regulation of gene expression is facilitated through different mechanisms such as DNA methylation, histone modifications and RNA-associated silencing by small non-coding RNAs. All these mechanisms are crucial for normal development, differentiation and tissue-specific gene expression. These three systems interact and stabilize one another and can initiate and sustain epigenetic silencing, thus determining heritable changes in gene expression. Histone acetylation regulates diverse cellular functions including inflammatory gene expression, DNA repair and cell proliferation. Transcriptional coactivators possess intrinsic histone acetyltransferase activity and this activity drives inflammatory gene expression. Eleven classical histone deacetylases (HDACs) act to regulate the expression of distinct subsets of inflammatory/immune genes. Thus, loss of HDAC activity or the presence of HDAC inhibitors can further enhance inflammatory gene expression by producing a gene-specific change in HAT activity. For example, HDAC2 expression and activity are reduced in lung macrophages, biopsy specimens, and blood cells from patients with severe asthma and smoking asthmatics, as well as in patients with chronic obstructive pulmonary disease (COPD). This may account, at least in part, for the enhanced inflammation and reduced steroid responsiveness seen in these patients. Other proteins, particularly transcription factors, are also acetylated and are targets for deacetylation by HDACs and sirtuins, a related family of 7 predominantly protein deacetylases. Thus the acetylation/deacetylation status of NF-κB and the glucocorticoid receptor can also affect the overall expression pattern of inflammatory genes and regulate the inflammatory response. Understanding and targeting specific enzymes involved in this process might lead to new therapeutic agents, particularly in situations in which current anti-inflammatory therapies are suboptimal.
Socio-Economic Inequalities in the Use of Postnatal Care in India

Objectives First, our objective was to estimate socio-economic inequalities in the use of postnatal care (PNC) compared with those in the use of care at birth and antenatal care. Second, we wanted to compare inequalities in the use of PNC between facility births and home births and to determine inequalities in the use of PNC among mothers with high-risk births. Methods and Findings Rich–poor ratios and concentration indices for maternity care were estimated using the third round of the District Level Household Survey conducted in India in 2007–08. Binary logistic regression models were used to examine the socio-economic inequalities associated with use of PNC after adjusting for relevant socio-economic and demographic characteristics. PNC for both mothers and newborns was substantially lower than the care received during pregnancy and child birth. Only 44% of mothers in India at the time of survey received any care within 48 hours after birth. Likewise, only 45% of newborns received check-up within 24 hours of birth. Mothers who had home births were significantly less likely to have received PNC than those who had facility births, with significant differences across the socio-economic strata. Moreover, the rich-poor gap in PNC use was significantly wider for mothers with birth complications. Conclusions PNC use has been unacceptably low in India given the risks of mortality for mothers and babies shortly after birth. However, there is evidence to suggest that effective use of pregnancy and childbirth care in health facilities led to better PNC. There are also significant socio-economic inequalities in access to PNC even for those accessing facility-based care. The coverage of essential PNC is inadequate, especially for mothers from economically disadvantaged households. The findings suggest the need for strengthening PNC services to keep pace with advances in coverage for care at birth and prenatal services in India through targeted policy interventions.
66–87 GHz power amplifier with 20dBm 1-dB compression point and 35% peak PAE in a 55nm SiGe technology

This paper presents the design of a mm-Wave PA for a transmitter of an E-Band mobile backhaul network, implemented using a 55nm SiGe BiCMOS technology. It has a 4-stage balanced CE configuration and the outputs are converted to single-ended using an integrated balun, which provides insertion losses smaller than 1dB at E-Band frequencies. The PA presents a maximum S21 of 15.5 dB at 74GHz and its 3-dB bandwidth covers from 66 to 87 GHz. Its output 1-dB compression point has a maximum of 20dBm and is above 18.75dBm across the whole E-Band, with a peak PAE of 35%. The different stages are externally biased and the Vcc voltage is 1.5V. The total DC power consumption is 275 mW.
People Recognition for Entering & Leaving a Video Surveillance Area

We proposed a people recognition method for moving people of entering & leaving a video surveillance area employing the spatial-based of single-pedestrian image in conjunction with color vector. The spatial-based is used because it is difference location for variance parts of the body. A histogram-based framework is used to describe the color vector of variance parts of the moving people. The method is able to tracking and identification successfully the moving people in different outdoor environment based on variance of samples. The experimental results illustrate that the method can automatically tracking and identification based on the moving people for entering & leaving a video surveillance area.
The lignocaine metabolite (MEGX) liver function test and P-450 induction in humans.

AIMS The N-deethylation of lignocaine to monoethylglycinexylidide (MEGX) is partially catalysed by the rifampicin inducible P-450 isoenzyme CYP3A4. This has led to the use of the MEGX test (MEGX plasma concentrations after i.v. lignocaine) as a marker of CYP3A4 activity. To test this hypothesis, we studied lignocaine and MEGX plasma pharmacokinetics. METHODS Ten healthy volunteers received rifampicin (600 mg day(-1)) for 6 days, resulting in a four- to sixfold increase in urinary 6beta-hydroxycortisol output. On days 1 and 7 (pretreatment), day 11 (treatment), and day 14 (48 h after rifampicin), 50 mg lignocaine i.v. was administered. MEGX concentrations at 30 min [MEGX30min] were assessed and normalised to MEGX test results after 1 mg kg(-1) lignocaine. On days 7 and 14 the lignocaine and MEGX plasma concentrations were measured over a 300 min period. MEGX test results and lignocaine and MEGX plasma pharmacokinetics before and after induction with rifampicin were compared. RESULTS The lignocaine plasma clearance increased from 7.5+/-1.2 ml min(-1) kg(-1) before to 8.6+/-2ml min(-1) kg(-1) (P=0.026) after induction. The normalised MEGX30min concentrations increased from 61+/-14 (day 7) to 82+/-34 microg l(-1) (day 14) by a mean of 21 microg l(-1) (95% confidence interval: -3 to 44 microg l(-1)) (P=0.055). CONCLUSION An insignificant increase of MEGX plasma concentrations was found in 10 volunteers after induction of CYP3A4 activity by rifampicin. Therefore, the MEGX test is not a sensitive marker of P-450 induction in healthy human liver.
Joint MS-GSC combining and down-link multiuser diversity scheduling

Exploiting multi-user diversity is one solution to efficiently use the wireless medium. The basic principle is to assign the resources to the user experiencing the best channel conditions based on a feedback information provided by different users. In this paper, we propose three multiuser scheduling schemes which are combinations between the switch and examine transmission scheme in the network layer and the joint minimum-selection generalized selection combining and adaptive modulation in the physical layer. As a first step, fairness of access is not taken into account in the design of the proposed scheduling schemes. Then, in a second step, the proposed schemes are modified in order to enable them to achieve a certain short term fairness of access. In both cases, we study the performance of the proposed schemes in terms of spectral efficiency, feedback load and rate, and average number of combined and estimated paths. Using some selected numerical examples, the proposed schemes are compared among themselves and also to some recently published schemes.