Miracle-dz/UniFAR-FTUs huggingface dataset:
Level of processing and reaction time in young and middle-aged adults and the effect of education

The first aim was to examine whether differences in reaction time (RT) between younger (25–35 years) and middle-aged (50–60 years) individuals increase with depth of processing. The second aim was to examine whether this increase is less pronounced in higher educated individuals. Processing of words at the perceptual, phonological, and semantic level was induced by a case decision, an “e” detection, and a living/nonliving discrimination task, respectively. RTs increased with age and level of processing. However, there were no interactions between age, task, and education, suggesting that different processing levels are equally sensitive to slowing in midlife and that education was not a moderating factor. Although no overall age by level of processing interaction was found, there were age by stimulus type interactions in the deeper processing tasks. First, age-related differences in RT for words containing the letter “e” were smaller than for words without the letter “e”, suggesting that middle-aged adults were slower than younger adults in performing a terminating search strategy. Second, age-related differences in RT for words referring to living items were smaller than for words referring to nonliving items. This suggests that middle-aged adults compared to younger adults have reduced access to specific semantic categories. Taken together, the results show that vulnerability to age-related cognitive decline already exists in middle age.
A methodology to build run-time monitors for security-aware workflows

Run-time monitors are crucial to the development of workflow management systems, which are at the heart of several modern E-services. In this paper, we propose a new methodology to build run-time monitors capable of ensuring the successful termination of workflows subject to authorization constraints. The methodology is based on state-of-the-art Satisfiability Modulo Theories techniques.
InSAR permanent scatterers selection using SAR SVA filtering

Permanent scatterers (PS) approach allows the identification of radar targets not affected by decorrelation noise then suitable for reliable SAR interferometric measurements. This paper introduces a new technique allowing the selection of stable scatterers based on adaptative SVA (Spatially Variant Apodization) filtering. Indeed, SVA filters identify SAR pixels with strong reflectivity (maximum of the mainlobe) over a long temporal series of interferometric SAR images which is the main feature of Permanent Scatterers pixels. A comparison between PS candidates pixels and selected SVA pixels is discussed in this study.
Variabilities and Dualities in Distributed Leadership

This article examines the concept of distributed leadership, drawing from a systematic review of relevant literature commissioned by the National College for School Leadership (NCSL) and jointly funded by NCSL and the Open University’s Centre for Educational Policy, Leadership and Lifelong Learning (CEPoLL). The concept attracts a range of meanings and is associated with a variety of practices, with varying implications for organizational processes and values. The article highlights key variables that emerged from the literature review. It then elaborates one of the emergent themes—the distinction between structure and agency—and seeks to utilize this further as a means of illuminating the concept and practice of distributed leadership. In conclusion, areas for future research are identified.
Performance Analysis of Soft Information Cooperation in Bi-Directional Networks

In this paper, we propose the soft information cooperation scheme in the bi-directional wireless relay networks.We ﬁrst compute the Log-Likelihood ratio (LLR), referred to as the soft information of relay received signal in Rayleigh fading channel, and then propose an efﬁcient LLR-based network coding scheme. Moreover, for computational simplicity, we optimize the soft information cooperation by the deﬁned self soft information at terminals. In addition, we analyze the system performance in terms of generalized signal-to-noise ratio (GSNR), which is shown to be an efﬁcient metric to reveal the BER performance, for one-relay and multi-relay cases. The simulation results show that the soft information cooperation scheme outperforms the traditional amplify-and-forward (AF), decode-and-forward (DF) and compress-and- forward (CF) protocols in terms of GSNR and bit- error rate (BER) in the low-SNR regime.
A Neural Network based power quality signal classification system using wavelet energy distribution

This paper presents a method for the classification of common Power Quality(PQ) events. The described system for the characterization of disturbances is based on wavelet based feature extraction. The amount of data to be analyzed and how the data can be interpreted are of crucial importance in power quality analysis. Wavelet Transform(WT) has been widely used in power quality signal analysis. The advantage of wavelet transform is it can provide precise time information of power quality events and has many advantages over traditional signal analysis approaches. In this paper Discrete Wavelet Transform(DWT) is used for obtaining the energy distribution from simulated signals. The system is developed with Neural Network which is an effective tool in classification of signals in power systems.
Regression of duodenal follicular lymphoma: susceptible to H. pylori eradication?

To the Editor We read the case report, “Regression of Follicular Lymphoma of the Duodenum Following Eradication of H. pylori Infection,” by Hayashi et al. (1) with interest. Based on the clinical outcome of the presented case, the authors suggested that Helicobacter pylori (H. pylori) eradication is effective for treating duodenal follicular lymphoma (FL). However, we noticed that several important articles relating this topic were not cited in this report. Schmatz et al. summarized the outcomes of 63 patients with stage I primary intestinal FL (2). Among these patients, 24 were followed up using a watchful wait-and-see attitude. Six patients received eradication therapy for H. pylori, after which complete regression was observed in only one patient; no responses were noted in the remaining five patients. However, five patients experienced spontaneous complete regression of FL without receiving eradication treatment for H. pylori. It is well known that, regarding FL of nodal origin, the natural course of the disease is characterized by spontaneous regression in up to 25% of cases (3). Yaguchi et al. reported a case of primary intestinal FL with duodenal, jejunal and ileal involvement (4). Although tests for H. pylori infection were negative, eradication therapy was administered in that patient. The duodenal lesions remained unchanged for 19 months prior to eradication treatment, while partial regression was observed three months after treatment. This case raises the possibility that an infectious organism other than H. pylori is responsible for the progression/regression of duodenal FL. Our latest work revealed a deviation of immunoglobulin heavy chain usage and memory B cell characteristics in patients with duodenal FL lesions (5). These pathological features strongly suggest the presence of antigen stimulation, which likely affects tumor spreading. Based on these results, we consider that the regression of duodenal FL can occur spontaneously under antigen stimulation, although the specific antigen and mechanisms have not been identified as yet. It is also unclear whether such antigen stimulation can be alleviated by H. pylori eradication treatment. At the present time, H. pylori eradication is a possible option for treating duodenal FL, as the therapy is relatively inexpensive and less harmful than other antitumor therapies. Although randomized controlled trials are unlikely to be conducted due to the infrequency of the disease, we believe that future retrospective case series and/or multi-center observational studies will reveal whether H. pylori eradication treatment is effective for inducing duodenal FL regression.
Theorizing gender and digital gameplay: Oversights, accidents and surprises

This paper attempts to tell a story of a different kind about gender and digital gameplay. Resisting the repetition of stereotypes about who plays, how and why, we show how, as researchers, our own assumptions and presumptions about gender keep surprise at bay, enforcing instead "findings" that solidify an inner "truth" about gender. Re-citing hegemonic gender ideologies that tell us nothing we don't already know, we argue here, is no accident. Rather than recurring encounters with the all-too-familiar, we are entitled to expect to be surprised by the research we do, and more serious interpretive work, in conjunction with alternative methodologies, promise very different findings than those hitherto attributed to women and girls playing games.
Temperature preconditioning is optimal at 26°C and confers additional protection to hypothermic cardioplegic ischemic arrest

We have recently shown that brief episodes of hypothermic perfusion interspersed with periods of normothermic perfusion, referred to as temperature preconditioning (TP), are cardioprotective and can be mimicked by consecutive isoproterenol/adenosine treatment. Here we investigate the optimal temperature for TP and whether TP further enhances protection provided by hypothermic ischemia with or without polarized cardioplegic arrest. Three experimental groups of Langendorff-perfused rat hearts were used. In the first group, hearts were subjected to three episodes of hypothermic perfusion at 7, 17, 26 and 32°C during the TP protocol, followed by 30 min normothermic index ischemia and 60 min reperfusion (37°C). Protein kinase A (PKA) activity and cyclic AMP (cAMP) concentrations were measured prior to index ischemia. In the second group, TP (26°C) hearts were subjected to two hours hypothermic index ischemia at 26°C and two hours normothermic reperfusion. In the third group, TP (26°C) hearts or hearts treated with isoproterenol/adenosine (pharmacological simulation of TP) were subjected to four hours hypothermic index ischemia with procaine-induced polarized cardioplegia at 26°C followed by two hours normothermic reperfusion. Hemodynamic function recovery, lactate dehydrogenase release and infarct size were used to assess cardioprotection. TP at 26°C resulted in highest cardioprotection, increased cAMP concentration and PKA activity, while TP at 7°C exacerbated ischemia/reperfusion damage, and had no effect on cAMP concentration or PKA activity. TP at 26°C also protected hearts during hypothermic ischemia with or without polarized cardioplegia. Isoproterenol/adenosine treatment conferred additional protection similar to TP. In conclusion, the study shows that TP-induced cardioprotection is temperature dependent and is optimal at 26°C; TP confers additional protection to hypothermia and polarized cardioplegia; and that the pharmacological treatment based on the mechanism of TP (consecutive isoproterenol/adenosine treatment) is a potential cardioprotective strategy that can be used during heart surgery and transplantation.
Assessment of Teacher Attitudes Toward Inclusion of Students with Disabilities: A Confirmatory Factor Analysis

The Teacher Integration Attitudes Questionnaire (TIAQ) was developed in order to assess the attitudes and beliefs of teachers (n = 110) with regard to the inclusion of students with disabilities in regular education settings. Using Structural Equation Modeling, the final structural model of the TIAQ comprised four constructs, namely, “Skills,” “Benefits,” “Acceptance,” and “Support. ” The final model was fully supported by the derivation sample of music education teachers (n = 54) and produced a Comparative Fit Index (CFI = 1.00). The replication sample of physical education teachers (n = 56) partially supported the generality of the TIAQ, (CFI = .844). Further, the internal consistency properties of the TIAQ (Cronbach’s alpha was .77 for both samples) were satisfactory. We conclude that the psychometric properties of the TIAQ were adequate, and it can be used as a valid assessment in evaluating the status of inclusion for students with disabilities as perceived by music education and physical education te.
La regulació de la vida escolar: el dialeg a les assemblees

La intencio d'aquest escrit es la de presentar les linies generals d'una recerca en curs sobre la interaccio en la construccio del coneixement moral a traves del dialeg 1 que te Iloc durant la realitzacio de I'activitat escolar denominada assemblea o tutoria en diverses escoles d'EGB i en diversos nivells escolars. La recerca iniciada te per objectius definir i explicar com es construeix I'activitat conjunta coneguda com a assemblea escolar, quins processos d'ensenyamentaprenentatge es construeixen durant I'activitat i quin es el paper, presumiblement decisiu, que tenen en aquest proces els mecanismes de mediacio semiotica en la interaccio entre mestres alumnes entre iguals.
Fit to a T: Spray-On Clothing, Craft, Commodity Fetishism, and the Agency of Objects

This article considers how spray-on clothing made by Fabrican Ltd. might illuminate and complicate our understandings of craft, commodity fetishism, and object agency. Fabrican is a chemical substance that is sprayed onto the body to create a garment. I am interested in the ways this fabric appears seamless, self-made, and organic; it ostensibly removes the labor and skill associated with handcrafted and machineproduced textiles and, when worn, resembles a second skin, both concealing and revealing the body underneath. In so doing it brings into sharp focus the complex ways we relate to clothing as an object of production and consumption.
Model antenna of 76 GHz post-wall waveguide fed parallel plate slot arrays

We have designed and fabricated a 76 GHz post-wall waveguide fed parallel plate slot array. We have realized uniform field distribution over most of the aperture with 4 dB amplitude and 20-degree phase ripples. The model antenna has achieved 29.7 dBi gain with 45% efficiency at 76.75 GHz even though it has a large reflection of -6.33 dB (23.2 %) at the input aperture. This result indicates that this antenna itself has a potential of high efficiency of about 55% after improvement of the input aperture by reduction of the reflection.
Potential of antibody–drug conjugates and novel therapeutics in breast cancer management

Progress in the treatment of cancer over the past decade has been slow. Targeting a mutated gene of an individual patient tumor, tumor-guided agents, and the first draft of the human genome sequence have created an overenthusiasm to achieve personalized medicine. However, we now know that this effort is misleading. Extreme interpatient and intratumor heterogeneity, scarce knowledge in how genome-wide mutational landscape and epigenetic changes affect transcriptional processes, gene expression, signaling transduction networks and cell regulation, and clinical assessment of temporary efficacy of targeted drugs explain the limitations of these currently available agents. Trastuzumab and a few other monoclonal antibodies or small-molecule tyrosine kinase inhibitors (TKIs) represent an exception to this rule. By blocking ligand-binding receptor in patients with human epidermal growth factor receptor 2 (HER2) amplification and overexpression, trastuzumab added to chemotherapy in HER2-positive patients has been proven to provide significant overall survival benefit in both metastatic and adjuvant settings. Lapatinib, a small-molecule dual inhibitor (TKI) of both HER2 and EGFR (epidermal growth factor receptor) pathways, has an antitumor activity translated into progression-free survival benefit in HER2-positive metastatic patients previously treated with a taxane, an anthracycline, and trastuzumab. Despite these advances, ~25% of patients with HER2-positive breast cancer experience recurrence in the adjuvant setting, while in the metastatic setting, median survival time is 25 months. In this review, we discuss the safety, efficacy, and limitations of the trastuzumab emtansine (T-DM1) conjugate in the treatment of HER2-positive metastatic breast cancer. We also highlight Phase III randomized trials, currently underway, using either the T-DM1 conjugate or various combinations of monoclonal antibodies and TKIs. Moreover, in contrast with all these agents developed on the basis of “central dogma” of simplified reductionist transcription and single gene–phenotype linear relationship, we summarize the emerging, amazing era of next-generation, transcriptional circuitry and intracellular signaling network-based drugs guided by the latest advances in genome science and dynamics of network biology.
Inability of medroxyprogesterone acetate to down regulate estrogen receptor level in human breast cancer

The influence of medroxyprogesterone acetate (MPA) on estrogen receptor (ER) and progesterone receptor (PR) levels was studied in 20 postmenopausal patients with ER‐positive and PR‐positive primary breast cancers. Each patient underwent drill biopsy and subsequently mastectomy. The drill biopsy and surgical specimens were assayed for the total ER and PR levels (cytosolic plus nuclear fraction) by enzyme immunoassay. Between the drill biopsy and mastectomy, ten patients received no treatment (control group) and the other ten patients were given MPA (1200 mg/day) for 7 days. In the control group, the total ER and PR levels of the surgical specimens decreased by 68.2 ± 7.3% and 60.7 ± 8.4%, respectively, taking the receptor values of the drill biopsy specimens as 100%, although no treatment was given preoperatively. This decrease seems to be attributable to the receptor degradation due to damages occurring during mastectomy. In the MPA group, the total ER and PR levels of the surgical specimens decreased by 64.2 ± 8.0% and 23.3 ± 7.6%, respectively. The decrease in PR, but not ER, was statistically significant between the control and MPA groups (P < 0.01). These results demonstrate that MPA down regulates PR but not ER in human breast cancer and challenge the conventional idea, extrapolated from the results on the endometrium and endometrial cancer, that MPA antagonizes endogenous estrogens by down regulating ER.
Dynamic Search Mechanism with Threat Prediction in a GNSS Receiver

With the development of GNSS and the application of multimode signals, efficient GNSS receiver research has become very important. However, threat signals in the received signal are inevitable, which will represent important threats to navigation applications and will lead to leakage and fault detection for the receiver. Therefore, the searches with threat prediction in GNSS signals have been regarded as the important problem for GNSS receivers. In view of the limitations and nonadaptability of the current search technologies as well as on the basis of the proportionality peak judgment mechanism, a dynamic search mechanism with threat prediction (DSM-TP) is proposed in this paper, in which we define a series of preset coefficients and a threat index to optimize the decision mechanism. The simulation results demonstrate that the DSM-TP method can predict the threat situation and can adapt to lower SNR environments compared to the traditional method. In addition, the DSM-TP method can avoid the impact of threats, and the detection capability of the new method is better than the detection capability of the traditional method.
Prospective derivation and validation of a clinical prediction rule for recurrent Clostridium difficile infection.

BACKGROUND & AIMS Prevention of recurrent Clostridium difficile infection (CDI) is a substantial therapeutic challenge. A previous prospective study of 63 patients with CDI identified risk factors associated with recurrence. This study aimed to develop a prediction rule for recurrent CDI using the above derivation cohort and prospectively evaluate the performance of this rule in an independent validation cohort. METHODS The clinical prediction rule was developed by multivariate logistic regression analysis and included the following variables: age>65 years, severe or fulminant illness (by the Horn index), and additional antibiotic use after CDI therapy. A second rule combined data on serum concentrations of immunoglobulin G (IgG) against toxin A with the clinical predictors. Both rules were then evaluated prospectively in an independent cohort of 89 patients with CDI. RESULTS The clinical prediction rule discriminated between patients with and without recurrent CDI, with an area under the curve of the receiver-operating-characteristic curve of 0.83 (95% confidence interval [CI]: 0.70-0.95) in the derivation cohort and 0.80 (95% CI: 0.67-0.92) in the validation cohort. The rule correctly classified 77.3% (95% CI: 62.2%-88.5%) and 71.9% (95% CI: 59.2%-82.4%) of patients in the derivation and validation cohorts, respectively. The combined rule performed well in the derivation cohort but not in the validation cohort (area under the curve of the receiver-operating-characteristic curve, 0.89 vs 0.62; diagnostic accuracy, 93.8% vs 69.2%, respectively). CONCLUSIONS We prospectively derived and validated a clinical prediction rule for recurrent CDI that is simple, reliable, and accurate and can be used to identify high-risk patients most likely to benefit from measures to prevent recurrence.
Every Breath You Take? Environmental Justice and Air Pollution in Christchurch, New Zealand

In a number of environmental-justice studies it has been noted that the exposure to an array of air pollutants varies between different social groups. This inequality in exposure is one possible explanation for the variations in pollution-related health outcomes such as lung cancer and other respiratory diseases. Previous environmental-justice studies that have focused upon air pollution have tended to be concerned with exposure to industrial and vehicle pollution and rely upon simple estimates of exposure, ignoring the complex interaction of emissions, topography, and meteorology that determine pollution levels in many urban areas. In this paper we use accurate and geographically detailed estimates of pollution calculated from an atmospheric dispersion model to examine issues of environmental justice related to air pollution sourced from domestic heating in Christchurch, New Zealand, a city with particularly high levels of particulate pollution during winter months. We consider whether there is a social gradient in exposure to air pollution in Christchurch by comparing estimates of particulate pollution for small areas across the city to a range of demographic and socioeconomic indicators including age, ethnicity, income, and deprivation. Furthermore, we examine whether there is a social gradient in exposure to extreme pollution episodes. We demonstrate that different social groups in the Christchurch population are exposed to different levels of both ambient air pollution and extreme air-pollution episodes. In particular, pollution is significantly higher among more disadvantaged communities. We also find evidence which suggests that the groups responsible for producing a large proportion of the pollution in Christchurch are not the same groups exposed to high levels of particulate air pollution.