Miracle-dz/UniFAR-FTUs huggingface dataset:
Teacher Credentials and Student Achievement in High School: A Cross-Subject Analysis with Student Fixed Effects

We use data on statewide end-of-course tests in North Carolina to examine the relationship between teacher credentials and student achievement at the high school level. We find compelling evidence that teacher credentials, particularly licensure and certification, affects student achievement in systematic ways and that the magnitudes are large enough to be policy relevant. Our findings imply that the uneven distribution of teacher credentials by race and socioeconomic status of high school students—a pattern we also document—contributes to achievement gaps in high school. In addition, some troubling findings emerge related to the gender and race of the teachers.
Stathmin decreases cholangiocarcinoma cell line sensitivity to staurosporine-triggered apoptosis via the induction of ERK and Akt signaling

Cholangiocarcinoma is a rare, but highly fatal malignancy. However, the intrinsic mechanism involved in its tumorigenesis remains obscure. An urgent need remains for a promising target for cholangiocarcinoma biological therapies. Based on comparative proteomical technologies, we found 253 and 231 different spots in gallbladder tumor cell lines and cholangiocarcinoma cell lines, respectively, relative to non-malignant cells. Using Mass Spectrometry (MS) and database searching, we chose seven differentially expressed proteins. High Stathmin expression was found in both cholangiocarcinoma and gallbladder carcinoma cells. Stathmin expression was validated using immunohistochemistry and western blot in cholangiocarcinoma tissue samples and peritumoral tissue. It was further revealed that high Stathmin expression was associated with the repression of staurosporine-induced apoptosis in the cholangiocarcinoma cell. Moreover, we found that Stathmin promoted cancer cell proliferation and inhibited its apoptosis through protein kinase B (Akt) and extracellular signal-regulated kinase (ERK) signaling. Integrin, β1 appears to serve as a partner of Stathmin induction of ERK and Akt signaling by inhibiting apoptosis in the cholangiocarcinoma cell. Understanding the regulation of anti-apoptosis effect by Stathmin might provide new insight into how to overcome therapeutic resistance in cholangiocarcinoma.
On supervisory control of sequential behaviors

The authors address the supervisory synthesis problem of controlling the sequential behaviors of discrete-event dynamical systems (DEDSs) under complete and partial information through the use of synchronous composition of the plants and the supervisors. The authors present the notion of complete languages, discuss some of its algebraic properties, and show its close relation to omega -languages. The authors prove that the supremal (closed) complete and controllable sublanguage of a given language exists, and present an algorithm to compute it. They present a closed-form expression for the supremal omega -controllable sublanguage of a given omega -language in terms of the supremal (closed) complete and controllable sublanguage. This closed-form expression suggests that certain operations on a given omega -language can alternatively be achieved by performing certain other similar operations on its prefix (which is a finite language) and then taking the limit (to obtain the desired omega -language). A necessary and sufficient condition for the existence of a supervisor in case of partial observation is presented in terms of omega -observability. Notion of omega -normality is also introduced, and a closed-form expression for the supremal omega -normal sublanguage, in terms of the supremal closed, complete, and normal sublanguage, is presented. >
Characterization of the Gallate Dioxygenase Gene: Three Distinct Ring Cleavage Dioxygenases Are Involved in Syringate Degradation by Sphingomonas paucimobilis SYK-6

ABSTRACT Sphingomonas paucimobilis SYK-6 converts vanillate and syringate to protocatechuate (PCA) and 3-O-methylgallate (3MGA) in reactions with the tetrahydrofolate-dependent O-demethylases LigM and DesA, respectively. PCA is further degraded via the PCA 4,5-cleavage pathway, whereas 3MGA is metabolized via three distinct pathways in which PCA 4,5-dioxygenase (LigAB), 3MGA 3,4-dioxygenase (DesZ), and 3MGA O-demethylase (LigM) are involved. In the 3MGA O-demethylation pathway, LigM converts 3MGA to gallate, and the resulting gallate appears to be degraded by a dioxygenase other than LigAB or DesZ. Here, we isolated the gallate dioxygenase gene, desB, which encodes a 418-amino-acid protein with a molecular mass of 46,843 Da. The amino acid sequences of the N-terminal region (residues 1 to 285) and the C-terminal region (residues 286 to 418) of DesB exhibited ca. 40% and 27% identity with the sequences of the PCA 4,5-dioxygenase β and α subunits, respectively. DesB produced in Escherichia coli was purified and was estimated to be a homodimer (86 kDa). DesB specifically attacked gallate to generate 4-oxalomesaconate as the reaction product. The Km for gallate and the Vmax were determined to be 66.9 ± 9.3 μM and 42.7 ± 2.4 U/mg, respectively. On the basis of the analysis of various SYK-6 mutants lacking the genes involved in syringate degradation, we concluded that (i) all of the three-ring cleavage dioxygenases are involved in syringate catabolism, (ii) the pathway involving LigM and DesB plays an especially important role in the growth of SYK-6 on syringate, and (iii) DesB and LigAB are involved in gallate degradation.
CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex

CLIP-associating protein (CLASP) 1 and CLASP2 are mammalian microtubule (MT) plus-end binding proteins, which associate with CLIP-170 and CLIP-115. Using RNA interference in HeLa cells, we show that the two CLASPs play redundant roles in regulating the density, length distribution and stability of interphase MTs. In HeLa cells, both CLASPs concentrate on the distal MT ends in a narrow region at the cell margin. CLASPs stabilize MTs by promoting pauses and restricting MT growth and shortening episodes to this peripheral cell region. We demonstrate that the middle part of CLASPs binds directly to EB1 and to MTs. Furthermore, we show that the association of CLASP2 with the cell cortex is MT independent and relies on its COOH-terminal domain. Both EB1- and cortex-binding domains of CLASP are required to promote MT stability. We propose that CLASPs can mediate interactions between MT plus ends and the cell cortex and act as local rescue factors, possibly through forming a complex with EB1 at MT tips.
Overexpression of Functionally Coupled Cyclooxygenase-2 and Prostaglandin E Synthase in Symptomatic Atherosclerotic Plaques as a Basis of Prostaglandin E2-Dependent Plaque Instability

Background—Studies have implicated a role for prostaglandin (PG) E2-dependent matrix metalloproteinase (MMP) biosynthesis in the rupture of atherosclerotic plaque. Cyclooxygenase-2 (COX-2) and PGE synthase (PGES) are coregulated in nucleated cells by inflammatory stimuli. The aim of this study was to characterize the expression of COX-2 and PGES in carotid plaques and to correlate it with the extent of inflammatory infiltration and MMP activity and with clinical features of patients’ presentation. Methods and Results—Plaques were obtained from 50 patients undergoing carotid endarterectomy and divided into 2 groups (symptomatic and asymptomatic) according to clinical evidence of recent transient ischemic attack or stroke. Plaques were analyzed for COX-2, PGES, MMP-2, and MMP-9 by immunocytochemistry and Western blot, whereas zymography was used to detect MMP activity. Immunocytochemistry was used to identify CD68+ macrophages, CD3+ T lymphocytes, and HLA-DR+ cells. The percentage of macrophage-rich areas was larger (P <0.0001) in symptomatic plaques. COX-2, PGES, and MMPs were detected in all specimens; enzyme concentration, however, was significantly higher in symptomatic plaques. COX-2, PGES, and MMPs were especially noted in shoulders of symptomatic plaques, colocalizing with HLA-DR+ macrophages. All symptomatic plaques contained activated forms of MMPs. Finally, inhibition of COX-2 by NS-398 was accompanied by decreased production of MMPs that was reversed by PGE2. Conclusions—This study demonstrates the colocalization of COX-2 and PGES in symptomatic lesions and provides evidence that synthesis of COX-2 and PGES by activated macrophages is associated with acute ischemic syndromes, possibly through metalloproteinase-induced plaque rupture.
Engagement of Health Plans and Employers in Addressing Racial and Ethnic Disparities in Health Care

Disparities in access to and quality of health care along racial and ethnic lines are an important national problem. Health care purchasers and payers have a potentially important role to play in alleviating this problem. Using national surveys of 609 employers and 252 health plans with HMO products in 41 U.S. markets, we examined awareness of racial and ethnic disparities in health care access and quality, perceptions of employer and health plan role in addressing disparities, and reported efforts to measure and reduce disparities. Our findings suggest that most health plans and many employers are aware of the existence of substantial disparities and that health plans, but not employers, have taken steps to examine and influence patterns of care by race and ethnicity among their members.
Maximizing diversity in biology and beyond

Entropy, under a variety of names, has long been used as a measure of diversity in ecology, as well as in genetics, economics and other fields. There is a spectrum of viewpoints on diversity, indexed by a real parameter q giving greater or lesser importance to rare species. Leinster and Cobbold proposed a one-parameter family of diversity measures taking into account both this variation and the varying similarities between species. Because of this latter feature, diversity is not maximized by the uniform distribution on species. So it is natural to ask: which distributions maximize diversity, and what is its maximum value? In principle, both answers depend on q, but our main theorem is that neither does. Thus, there is a single distribution that maximizes diversity from all viewpoints simultaneously, and any list of species has an unambiguous maximum diversity value. Furthermore, the maximizing distribution(s) can be computed in finite time, and any distribution maximizing diversity from some particular viewpoint q > 0 actually maximizes diversity for all q. Although we phrase our results in ecological terms, they apply very widely, with applications in graph theory and metric geometry.
An 826 MOPS, 210uW/MHz Unum ALU in 65 nm

To overcome the limitations of conventional floating-point number formats, an interval arithmetic and variable-width storage format called universal number (unum) has been recently introduced [1]. This paper presents the first (to the best of our knowledge) silicon implementation measurements of an application-specific integrated circuit (ASIC) for unum floating-point arithmetic. The designed chip includes a 128-bit wide unum arithmetic unit to execute additions and subtractions, while also supporting lossless (for intermediate results) and lossy (for external data movements) compression units to exploit the memory usage reduction potential of the unum format. Our chip, fabricated in a 65 nm CMOS process, achieves a maximum clock frequency of 413 MHz at 1.2 V with an average measured power of 210uW/MHz.
Analysis of linear electrode array EMG for assessment of hemiparetic biceps brachii muscles

This study presents a frequency analysis of surface electromyogram (EMG) signals acquired by a linear electrode array from the biceps brachii muscles bilaterally in 14 hemiparetic stroke subjects. For different levels of isometric contraction ranging from 10 to 80% of the maximum voluntary contraction (MVC), the power spectra of 19 bipolar surface EMG channels arranged proximally to distally along the muscle fibers were examined in both paretic and contralateral muscles. It was found that across all stroke subjects, the median frequency (MF) and the mean power frequency (MPF), averaged from different surface EMG channels, were significantly smaller in the paretic muscle compared to the contralateral muscle at each of the matched percent MVC contractions. The muscle fiber conduction velocity (MFCV) was significantly slower in the paretic muscle than in the contralateral muscle. No significant correlation between the averaged MF, MPF, or MFCV vs. torque was found in both paretic and contralateral muscles. However, there was a significant positive correlation between the global MFCV and MF. Examination of individual EMG channels showed that electrodes closest to the estimated muscle innervation zones produced surface EMG signals with significantly higher MF and MPF than more proximal or distal locations in both paretic and contralateral sides. These findings suggest complex central and peripheral neuromuscular alterations (such as selective loss of large motor units, disordered control of motor units, increased motor unit synchronization, and atrophy of muscle fibers, etc.) which can collectively influence the surface EMG signals. The frequency difference with regard to the innervation zone also confirms the relevance of electrode position in surface EMG analysis.
Synthetic Ethology and the Evolution of Cooperative Communication

Synthetic ethology is proposed as a means of conducting controlled experiments investigating the mechanisms and evolution of communication. After a discussion of the goals and methods of synthetic ethology, two series of experiments are described based on at least 5000 breeding cycles. The first demonstrates the evolution of cooperative communication in a population of simple machines. The average fitness of the population and the organization of its use of signals are compared under three conditions: communication suppressed, communication permitted, and communication permitted in the presence of learning. Where communication is permitted, the fitness increases approximately 26 times faster than when communication is suppressed; with communication and learning, the rate of fitness increase is nearly 100-fold The second series of experiments illustrates the evolution of a syntactically simple language, in which a pair of signals is required for effective communication.
Contextual Information Provision on Augmented Reality with IoT-Based Semantic Communication

During the last decades, a number of researches have been focusing on contextual information provisioning in ubiquitous environment. Among many research works from them, AR and IoT are recently getting many attentions as promising technologies for next generation of contextual information provisioning and invested for their potentials. However, current ARUI for real world browsing has limitations that it doesn't take care of variability on meanings of things depending on contexts. AR as well as IoT field has many issues to address this problem, but one of the most fundamental challenges is how to synthesize exploding information in IoT environment and which information to view on ARUI out of them. To address this problem, we suggest IoT platform side communication scheme, semantic communication, as a core component and its architecture based on design considerations. To provide situation-appropriate contextual information over the whole system with ARUI, we're currently collaborating with other Vision and UI groups and expecting to expand the dimension of contextual information to be provided to users.
Freezing-and-Thawing Durability of Pervious Concrete under Simulated Field Conditions

This research investigates the durability of pervious concrete under simulated field conditions, including slow cyclic freezing and thawing, wet-dry environments, and salt applications. Specifically, this research examines the effects of materials and proportions and curing conditions on the freezing-and-thawing durability of pervious concrete. Generally, air curing causes a dramatic reduction in the freezing-and-thawing durability as compared with water curing. Silica fume additions are observed to improve the performance of water-cured pervious concrete during slow freezing and thawing while causing a significant drop in the performance of air-cured specimens. Polypropylene fibers are seen to enhance the resistance of pervious concrete to repeated freezing and thawing, whereas salt applications are noted to aggravate the deterioration. In addition, wet-dry cycles are found to slow down the freezing-and-thawing damage development when the duration of the wet cycle is less than 3 days.
A pr 1 99 9 Ambiguities in Quantizing a Classical System

One classical theory, as determined by an equation of motion or set of classical trajectories, can correspond to many unitarily inequivalent quantum theories upon canonical quantization. This arises from a remarkable ambiguity, not previously investigated, in the construction of the classical (and hence the quantized) Hamiltonian or Lagrangian. This ambiguity is illustrated for systems with one degree of freedom: An arbitrary function of the constants of motion can be introduced into this construction. For example, the nonrelativistic and relativistic free particles follow identical classical trajectories, but the Hamiltonians or Lagrangians, and the canonically quantized versions of these descriptions, are inequivalent. Inequivalent descriptions of
Impact of Physician Asthma Care Education on Patient Outcomes*

Objective. We evaluated the effectiveness of a continuing medical education program, Physician Asthma Care Education, in improving pediatricians’ asthma therapeutic and communication skills and patients’ health care utilization for asthma. Methods. We conducted a randomized trial in 10 regions in the United States. Primary care providers were recruited and randomly assigned by site to receive the program provided by local faculty. The program included 2 interactive seminar sessions (2.5 hours each) that reviewed national asthma guidelines, communication skills, and key educational messages. Format included short lectures, case discussions, and a video modeling communication techniques. We collected information on parent perceptions of physicians’ communication, the child’s asthma symptoms, and patients’ asthma health care utilization. We used multivariate regression models to determine differences between control and intervention groups. Results. A total of 101 primary care providers and a random sample of 870 of their asthma patients participated. After 1 year, we completed follow-up telephone interviews with the parents of 731 of the 870 patients. Compared to control subjects, parents reported that physicians in the intervention group were more likely to inquire about patients’ concerns about asthma, encourage patients to be physically active, and set goals for successful treatment. Patients of physicians that attended the program had a greater decrease in days limited by asthma symptoms (8.5 vs 15.6 days), as well as decreased emergency department asthma visits (0.30 vs 0.55 visits per year). Conclusions. The Physician Asthma Care Education program was used in a range of locations and was effective in improving parent-reported provider communication skills, the number of days affected by asthma symptoms, and asthma health care use. Patients with more frequent asthma symptoms and higher health care utilization at baseline were more likely to benefit from their physician’s participation in the program.
Postnatal Cytomegalovirus Exposure in Infants of Antiretroviral-Treated and Untreated HIV-Infected Mothers

HIV-1 and CMV are important pathogens transmitted via breastfeeding. Furthermore, perinatal CMV transmission may impact growth and disease progression in HIV-exposed infants. Although maternal antiretroviral therapy reduces milk HIV-1 RNA load and postnatal transmission, its impact on milk CMV load is unclear. We examined the relationship between milk CMV and HIV-1 load (4–6 weeks postpartum) and the impact of antiretroviral treatment in 69 HIV-infected, lactating Malawian women and assessed the relationship between milk CMV load and postnatal growth in HIV-exposed, breastfed infants through six months of age. Despite an association between milk HIV-1 RNA and CMV DNA load (0.39 log10 rise CMV load per log10 rise HIV-1 RNA load, 95% CI 0.13–0.66), milk CMV load was similar in antiretroviral-treated and untreated women. Higher milk CMV load was associated with lower length-for-age (−0.53, 95% CI: −0.96, −0.10) and weight-for-age (−0.40, 95% CI: −0.67, −0.13) Z-score at six months in exposed, uninfected infants. As the impact of maternal antiretroviral therapy on the magnitude of postnatal CMV exposure may be limited, our findings of an inverse relationship between infant growth and milk CMV load highlight the importance of defining the role of perinatal CMV exposure on growth faltering of HIV-exposed infants.
A new design of support for burst-prone rock mass in underground ore mining

The article presents the basic methods of strengthening room and roadway excavations in underground ore mining. In particular, it was pointed out that the mining support is very often exposed to additional dynamic loads resulting from the mining of the deposit by means of explosives (slight) as well as from the load arising from rock mass tremors. In the article a new design of arch yielding support adapted to dynamic loads, which can be used in long-term access excavations was proposed. For this case, an exemplary spring deflection, which is located in the support foot cylinder, based on the principle of work and energy was calculated. In the case of exploitation room excavations, laboratory tensile tests of the long expansion rock bolt support, which were carried out in the rock bolting laboratory at the Department of Underground Mining AGH were presented. Load-displacement characteristics for long expansion rock bolt support with a particular indication of the elastic and plastic range were presented. In the summary, it was concluded that with the increase in the depth of exploitation, safe and efficient mining will be possible only due to the use of a support with appropriate yielding.