Miracle-dz/UniFAR-FTUs huggingface dataset:
Monitoring seasonal and long-term changes in test performance in elite swimmers

Abstract The purpose of this study was to characterize changes and variability in test performance of swimmers within and between seasons over their elite competitive career. Forty elite swimmers (24 male, 16 female) performed a 7×200-m incremental swimming step test several times each 6-month season (10±5 tests, spanning 0.5–6.0 y). Mixed linear modeling provided estimates of percent change in the mean and individual responses (within-athlete variation as a coefficient of variation) for measures based on submaximal performance (fixed 4-mM lactate), maximal performance (the seventh step) and lean mass (from skinfolds and body mass). Submaximal and maximal swim speed increased within each season from pre to taper phase by ∼2.2% for females and ∼1.5% for males (95% confidence limits ±1.0%), with variable contributions from stroke rate and stroke length. Most of the gains in speed were lost in the off-season, leaving a net average annual improvement of ∼1.0% for females and ∼0.6% for males (±1.0%). For submaximal and maximal speed, individual variation between phases was ±2.2% and the typical measurement error was ±0.80%. Step test and anthropometric measures can be used to confidently monitor progressions in swimmers in an elite training program within and between seasons.
Time Course of Comparison

Similarity as interactive activation and mapping (SIAM), a model of the dynamic course of similarity comparisons, is presented. According to SIAM, when structured scenes are compared, the parts of one scene must be aligned, or placed in correspondence, with the parts from the other scene. Emerging correspondences influence each other in a manner such that, with sufficient time, the strongest correspondences are those that are globally consistent with other correspondences. Relative to globally inconsistent feature matches, globally consistent feature matches influence similarity more when greater amounts of time are given for a comparison. A common underlying process model of scene alignment accounts for commonalities between different task conditions. Differences between task conditions are accounted for by principled parametric variation within the model. The similarity of some situations is immediately apparent. The basis for the similarity of the The Odyssey and The Iliad is clear at once (both are Greek epic poems). Recognizing the commonalities between The Odyssey and The Wizard of Oz, however, is a relatively slow process. The time course of similarity assessments provides a useful tool for investigating the process by which entities are compared. These time course data inform questions concerning how entities are mentally represented and have important implications for theories of similarity. In this article, we present a model of similarity comparison that makes specific time course predictions, which were tested in three experiments. Before turning to that model, we first outline the need for a consideration of similarity processes.
Symptom Dimensions of Attention Deficit Hyperactivity Disorder and Nicotine Withdrawal Symptoms

Research suggests that Attention Deficit Hyperactivity Disorder (ADHD) and nicotine withdrawal symptoms are related; however, it is unknown how this relationship extends across ADHD symptom gradations, differs between inattention and hyperactivity-impulsivity symptom types, and generalizes to a national sample. This study examined cross-sectional associations between childhood ADHD symptom indexes (total, inattention, and hyperactivity-impulsivity) and lifetime DSM-IV nicotine withdrawal symptoms. Results showed that each ADHD symptom index associated with almost every withdrawal symptom (Ps < .01). After controlling for hyperactivity-impulsivity and inattention symptom overlap, inattention (but not hyperactivity-impulsivity) retained incremental associations with most withdrawal symptoms. These findings are relevant for understanding mechanisms of ADHD and smoking comorbidity.
NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2

As a genome guardian, p53 maintains genome stability by arresting cells for damage repair or inducing cell apoptosis to eliminate the damaged cells in stress response. Several nucleolar proteins stabilize p53 by interfering Mdm2–p53 interaction upon cellular stress, while other mechanisms by which nucleolar proteins activate p53 remain to be determined. Here, we identify NAT10 as a novel regulator for p53 activation. NAT10 acetylates p53 at K120 and stabilizes p53 by counteracting Mdm2 action. In addition, NAT10 promotes Mdm2 degradation with its intrinsic E3 ligase activity. After DNA damage, NAT10 translocates to nucleoplasm and activates p53‐mediated cell cycle control and apoptosis. Finally, NAT10 inhibits cell proliferation and expression of NAT10 decreases in human colorectal carcinomas. Thus, our data demonstrate that NAT10 plays a critical role in p53 activation via acetylating p53 and counteracting Mdm2 action, providing a novel pathway by which nucleolar protein activates p53 as a cellular stress sensor.
Clinical trials of behavioural interventions with heterogeneous teaching subgroup effects

Behaviour modification is often delivered to teaching subgroups. For example, experimental and control smoking cessation programmes may be given to 15 classes (subgroups) with 10 (otherwise independent) individuals. We present general statistical tests and power estimates to compare continuous outcomes from two interventions in settings where the magnitude of teaching subgroup heterogeneity, number of subgroups and subgroup size can differ between intervention arms. An application is made to data from a trial to reduce disease‐transmitting sexual behaviour. The statistical impact of teaching subgroup heterogeneity effect increases as the (a) number of participants in a subgroup increases, and (b) ratio of ‘averaged experimental and control subgroup effect variance’ to study subject variance increases. If plausible levels of subgroup teaching effect heterogeneity are ignored, the true sizes of tests with nominal 0.05 two‐sided type I errors range from 0.055 to 0.47, while when planning studies, estimated sample sizes are only 11.1–95.2 per cent of the true requirements. Copyright © 2002 John Wiley & Sons, Ltd.
Ceph : A Scalable Object-Based Storage System Technical Report UCSC-SSRC-06-01 March 2006

The data storage needs of large high-performance and general-purpose computing environments are generally best served by distributed storage systems. Traditional so lutions, exemplified by NFS, provide a simple distributed storage system model, but cannot meet the demands of high-performance computing environments where a single server may become a bottleneck, nor do they scale well due to the need to manually partition (or repartition) the data among the servers. Object-based storage promises to address these needs through a simple networked data storage unit, the Object Storage Device (OSD) that manages all local storage issues and exports a simple read/write data interface. Despite this simple concept, many challenges remain, including efficient object storage, centralized metadata management, data and metadata replication, and data and metadata reliability. We describe Ceph, a distributed object-based storage system that meets these challenges, providing highperformance file storage that scales directly with the number of OSDs and Metadata servers.
Late homograft valve insertion after transannular patch repair of tetralogy of Fallot.

BACKGROUND AND AIMS OF THE STUDY Transannular patch repair of tetralogy of Fallot leads to pulmonary insufficiency and progressive right ventricular dilatation responsible for a decreased exercise capacity. We studied the impact of late homograft insertion on the regression of the right ventricular volumes in symptomatic patients. METHODS Between July 1992 and August 1996, 15 consecutive patients (age range: 4 to 24 years) were operated on at a median of 13 years (range: 3 to 20 years) after transannular patch repair of tetralogy of Fallot. All patients complained of exertional dyspnea and fatigue. Syncopes were reported in six patients and four patients had sustained episodes of ventricular tachycardia. Fourteen had pulmonary regurgitation grade 3 or 4 and one had an associated stenosis and insufficiency. All patients had a dilated right ventricle. At reoperation, no patients presented with major aneurysm. The patch was resected and the right ventricular outflow tract reconstructed with a cryopreserved pulmonary homograft. Right ventricular volumes were studied before the procedures and at the last follow up consultation. RESULTS There was no operative death. One patient who had a concomitant patch repair of a hypoplastic left pulmonary artery needed extracorporeal circulatory support for eight days. After a median follow up of 25 months (range: 3 to 54 months) all patients but one are in NYHA class I. There were no late deaths. The mean end-diastolic diameter of the right ventricle decreased from 36 +/- 9 mm before surgery to 31 +/- 6 mm (not significant). The mean ratio between the end-diastolic diameter of the right and left ventricles decreased from 0.94 +/- 0.3 to 0.74 +/- 0.2 (p < 0.01). CONCLUSION An increasing number of patients who had transannular patch repair for tetralogy of Fallot will require reoperation for symptomatic long-term pulmonary regurgitation. Homograft reconstruction of the right ventricular outflow tract of these patients induces regression of their right ventricular dilatation and leads to their functional recovery.
A non-linear theory of the parallel firehose and gyrothermal instabilities in a weakly collisional plasma

Weakly collisional magnetized cosmic plasmas have a dynamical tendency to develop pressure anisotropies with respect to the local direction of the magnetic field. These anisotropies trigger plasma instabilities at scales just above the ion Larmor radius ρi and much below the mean free path λmfp. They have growth rates of a fraction of the ion cyclotron frequency, which is much faster than either the global dynamics or even local turbulence. Despite their microscopic nature, these instabilities dramatically modify the transport properties and, therefore, the macroscopic dynamics of the plasma. The non-linear evolution of these instabilities is expected to drive pressure anisotropies towards marginal stability values, controlled by the plasma beta βi. Here this non-linear evolution is worked out in an ab initio kinetic calculation for the simplest analytically tractable example – the parallel (k⊥= 0) firehose instability in a high-beta plasma. An asymptotic theory is constructed, based on a particular physical ordering and leading to a closed non-linear equation for the firehose turbulence. In the non-linear regime, both the analytical theory and the numerical solution predict secular (∝t) growth of magnetic fluctuations. The fluctuations develop a k−3∥ spectrum, extending from scales somewhat larger than ρi to the maximum scale that grows secularly with time (∝t1/2); the relative pressure anisotropy (p⊥−p∥)/p∥ tends to the marginal value −2/βi. The marginal state is achieved via changes in the magnetic field, not particle scattering. When a parallel ion heat flux is present, the parallel firehose mutates into the new gyrothermal instability (GTI), which continues to exist up to firehose-stable values of pressure anisotropy, which can be positive and are limited by the magnitude of the ion heat flux. The non-linear evolution of the GTI also features secular growth of magnetic fluctuations, but the fluctuation spectrum is eventually dominated by modes around a maximal scale ∼ρilT/λmfp, where lT is the scale of the parallel temperature variation. Implications for momentum and heat transport are speculated about. This study is motivated by our interest in the dynamics of galaxy cluster plasmas (which are used as the main astrophysical example), but its relevance to solar wind and accretion flow plasmas is also briefly discussed.
Analysing instrument mixes in quality assurance: the Czech and Slovak Accreditation Commissions in the era of mass higher education

Utilising insights from policy instrument theory, the article analyses the design, functioning and effects of the tools used by the Czech Accreditation Commission (CAC) and the Slovak Accreditation Commission (SAC) in the 2000s. Aside from programme accreditation, the other tools analysed are: institutional approval, institutional evaluations, evaluations of accredited activities and complex accreditations. Czech and Slovak programme accreditation is empirically evidenced to be very burdensome and have limited effectiveness. The commissions’ evaluative activities reveal some inconsistency of recommendations and missing follow-ups. Overall, the analysis suggests that the spillover effects of on-site evaluations on accreditation verdicts are likely to limit long-term improvement intra-institutionally, causing inconsistency of the instrument mix applied by the CAC and the SAC. Due to these design discrepancies, the change-over from programme accreditation to quality audit, resulting in an approval-audit mix, is argued for as a viable development trajectory of Czech and Slovak systemic quality assurance.
The Relationship between Dyslexia and Meares-Irlen Syndrome.

Meares-Irlen Syndrome (MIS) is characterised by symptoms of visual stress and visual perceptual distortions that are alleviated by using individually prescribed coloured filters. Coloured overlays (sheets of transparent plastic that are placed upon the page) are used to screen for the condition. MIS is diagnosed on the basis of either the sustained voluntary use of an overlay or an immediate improvement (typically of more than 5%) on the Wilkins Rate of Reading Test (WRRT). Various studies are reviewed suggesting a prevalence of 20–34% using these criteria. Stricter criteria give a lower prevalence: for example, 5% of the population read more than 25% faster with an overlay. It has been alleged that MIS is more common in dyslexia, but this has not been systematically investigated. We compared a group of 32 dyslexic with 32 control children aged 7–12 years, matched for age, gender and socio-economic background. Participants were tested with Intuitive Overlays, and those demonstrating a preference had their rate of reading tested using the WRRT with and without their preferred overlay. Both groups read faster with the overlay, and more so in the dyslexic group. ANOVA revealed no significant effect of group, but a significant improvement in WRRT with overlay (p=0.009) and a significant interaction between group and overlay (p=0.031). We found a similar prevalence of MIS in the general population to that in previous studies and a prevalence in the dyslexic group that was a little higher (odds ratio for >5% criterion: 2.6, 95% confidence limit 0.9–7.3). The difference in prevalence in the two groups did not reach statistical significance. We conclude that MIS is prevalent in the general population and possibly a little more common in dyslexia. Children with dyslexia seem to benefit more from coloured overlays than non-dyslexic children. MIS and dyslexia are separate entities and are detected and treated in different ways. If a child has both problems then they are likely to be markedly disadvantaged and they should receive prompt treatments appropriate to the two conditions. It is recommended that education professionals as well as eye-care professionals are alert to the symptoms of MIS and that children are screened for this condition, as well as for other visual anomalies.
Class dismissed? Youth resistance and the politics of race and class in South African education

Abstract Informed by the writings of the Frankfurt school and critical pedagogy, this article is a reflective piece on the engagement with the race and class debate in South African education. The article opens with the recent stampede to gain access to a university as a backdrop for an interrogation of the notions of race and class in both higher and basic education. Thereafter, the article highlights how universities and schools reproduce social and economic power systems to the detriment of the advancement of poor and working-class youth (the overwhelming majority of whom are black). The objective here is to encourage a deeper engagement with theoretical constructs of marginalisation, and racial and class inequalities. Over the past year there has been student unrest at 11 universities, and when one reflects on the youth resistance of the 1980s, it is evident that an academic engagement with discourses of power beyond polemic is needed to ensure that the youth take on the power brokers on equal terms.
Signaling Properties of Chemerin Receptors CMKLR1, GPR1 and CCRL2

Chemerin is a small chemotactic protein originally identified as the natural ligand of CMKLR1. More recently, two other receptors, GPR1 and CCRL2, have been reported to bind chemerin but their functional relevance remains poorly understood. In this study, we compared the binding and signaling properties of the three human chemerin receptors and showed differences in mode of chemerin binding and receptor signaling. Chemerin binds to all three receptors with low nanomolar affinities. However, the contribution of the chemerin C-terminus to binding efficiency varies greatly amongst receptors. By using BRET-based biosensors monitoring the activation of various G proteins, we showed that binding of chemerin and the chemerin 9 nonapeptide (149YFPGQFAFS157) to CMKLR1 activates the three Gαi subtypes (Gαi1, Gαi2 and Gαi3) and the two Gαo isoforms (Gαoa and Gαob) with potencies correlated to binding affinities. In contrast, no significant activation of G proteins was detected upon binding of chemerin to GPR1 or CCRL2. Binding of chemerin and the chemerin 9 peptide also induced the recruitment of β-arrestin1 and 2 to CMKLR1 and GPR1, though to various degree, but not to CCRL2. However, the propensity of chemerin 9 to activate β-arrestins relative to chemerin is higher when bound to GPR1. Finally, we showed that binding of chemerin to CMKLR1 and GPR1 promotes also the internalization of the two receptors and the phosphorylation of ERK1/2 MAP kinases, although with a different efficiency, and that phosphorylation of ERK1/2 requires both Gαi/o and β-arrestin2 activation but not β-arrestin1. Collectively, these data support a model in which each chemerin receptor displays selective signaling properties.
Fully-integrated DECT/Bluetooth multi-band LNA in 0.18 /spl mu/m CMOS

The design of a multi-band low noise amplifier (LNA) is the first obstacle towards the design of a multi-standard receiver. In this paper, an approach for the design of a multi-band LNA for DECT and Bluetooth is presented. The formula for a minimal noise factor of a LNA, that takes into account the finite quality factor of the inductors is derived and the full design procedure that facilitates the design of a fully integrated LNA is given. The main advantages of the presented multi-band LNA are: high level of integration, reduced chip area by using only one integrated inductor, while the other is implemented as a bond-wire, input matching at two frequencies while having low noise figure, moderate voltage gain and good linearity. In DECT mode the simulated LNA performance is: NF = 2.2 dB, gain = 17 dB, IIP3 = 0.5 dBm, with a current of 8 mA, while in Bluetooth mode the LNA achieves: NF = 2.3 dB, gain = 15 dB, IIP3 = 3 dBm, with a current of only 4 mA.
Efficacy of Coherence Therapy in the Treatment of Procrastination and Perfectionism

This study tested the efficacy of Coherence Therapy, compared with a self-help, bibliotherapy intervention, for people with procrastination and perfectionism problems. A total of 37 adults (65% male, 46% White, European American) were randomized to a Coherence Therapy intervention (n = 18) or a bibliotherapy condition (n = 19). Procrastination and perfectionism were assessed at pretreatment, posttreatment, and 6 months posttreatment. Analyses revealed that the Coherence Therapy group outperformed the bibliotherapy group in reducing maladaptive perfectionism but there were no substantial treatment effects on procrastination. Findings are discussed relevant to developing literature on Coherence Therapy and the treatment of perfectionism and procrastination.
The HRAF Probability Sample: Retrospect and Prospect

This paper reviews the selection of the original HRAF "probability sample" of sixty cultural units and the status of their respective data re trieval files. It presents a detailed description of the sampling procedure now being used for selecting an additional sixty cultural units, and a report on the status of the respective files developed thus far. Supporting manuals and computer programs are noted briefly.
Relationship of menstrual cycle and vaginal infection in female rhesus macaques challenged with repeated, low doses of SIVmac251

Varying susceptibility during menstrual cycling could be a factor for S(H)IV infection risk in female rhesus macaques. We retrospectively determined vaginal SIV infection time points relative to the menstrual cycle in a group of rhesus macaques (n=11) enrolled in an HIV transmission trial. Eight of nine rhesus macaques became infected around menstruation time.
Production of spontaneous and posed facial expressions in patients with Huntington's disease: Impaired communication of disgust

Several studies have reported impairment in the recognition of facial expressions of disgust in patients with Huntington's disease (HD) and preclinical carriers of the HD gene. The aim of this study was to establish whether impairment for disgust in HD patients extended to include the ability to express the emotion on their own faces. Eleven patients with HD, and 11 age and education matched healthy controls participated in three tasks concerned with the expression of emotions. One task assessed the spontaneous production of disgust-like facial expressions during the smelling of offensive odorants. A second assessed the production of posed facial expressions during deliberate attempts to communicate emotion. The third task evaluated HD patients’ ability to imitate the specific facial configurations associated with each emotion. Foul odours induced fewer disgust-like facial reactions in HD patients than in controls, and patients’ posed facial expressions of disgust were less accurate than the posed disgust expressions of controls. The effect was selective to disgust; patients had no difficulty posing expressions of other emotions. These impairments were not explained by compromised muscle control: HD patients had no difficulty imitating the facial movements required to display disgust. Viewed together with evidence of difficulty in other aspects of disgust in HD, the findings suggest that a common substrate might participate in both the processing and the expression of this emotion.
Quantitative Radiographic Analysis of Fiber Reinforced Polymer Composites

X-ray radiographic examination of the bone fracture healing process is a widely used method in the treatment and management of patients. Medical devices made of metallic alloys reportedly produce considerable artifacts that make the interpretation of radiographs difficult. Fiber reinforced polymer composite materials have been proposed to replace metallic alloys in certain medical devices because of their radiolucency, light weight, and tailorable mechanical properties. The primary objective of this paper is to provide a comparable radiographic analysis of different fiber reinforced polymer composites that are considered suitable for biomedical applications. Composite materials investigated consist of glass, aramid (Kevlar-29), and carbon reinforcement fibers, and epoxy and polyether-ether-ketone (PEEK) matrices. The total mass attenuation coefficient of each material was measured using clinical X-rays (50 kev). The carbon fiber reinforced composites were found to be more radiolucent than the glass and kevlar fiber reinforced composites.