Miracle-dz/UniFAR-FTUs huggingface dataset:
Ribosomes and secretory granules in human mast cells: close associations demonstrated by staining with a chelating agent

Summary: The distribution of ribosomes was investigated in mature human mast cells with a chelation‐based staining protocol known to bleach DNA‐rich structures, leaving RNA‐rich structures unbleached. With this method, electron‐dense ribosomes were adjacent to, attached to, and within secretory granules, which were also bleached with the chelation method that we used. The finding of these ribosome–secretory granule relationships suggests that secretory granules in mature human mast cells may participate in RNA metabolism.
Gentrification in central moscow ‐ a market process or a deliberate policy? money, power and people in housing regeneration in ostozhenka

ABSTRACT. The recent process of housing redevelopment in central Moscow is examined in the light of the theory of gentrification. The study is based on the case of Ostozhenka as an emblematic example of a large–scale transformation of a central residential neighbourhood into the most expensive quarter of central Moscow. Using data collected through interviews, archive enquiries and field surveys, the paper addresses the preconditions, dynamics and mechanisms of this socio–political process. It is argued that gentrification in Ostozhenka shares many features observed in the other large cities of the world but, as predicted by theory, is locally embedded. It has been a product of a complex interplay of the market pressure aiming to meet demands from Moscow's successful post–Soviet economy and Moscow government's entrepreneurial and pro–development strategy for the city centre regeneration. The government privileges market forces: it empowers them vis‐à‐vis the original population and allows them to circumvent conservation institutions, while the achieved profit is shared between the private and public sides. Whereas the physical improvement of the city centre signifies departing from the Soviet legacies of under–investments in the housing built environment, the growing socio–spatial polarization undermines the social achievements of the Soviet system and denotes the triumph of the neoliberal urban regime in Moscow.
Using MaxBMC for Pareto-optimal circuit initialization

In this paper we present MaxBMC, a novel formalism for solving optimization problems in sequential systems. Our approach combines techniques from symbolic SAT-based Bounded Model Checking (BMC) and incremental MaxSAT, leading to the first MaxBMC solver. In traditional BMC safety and liveness properties are validated. We extend this formalism: in case the required property is satisfied, an optimization problem is defined to maximize the quality of the reached witnesses. Further, we compare its qualities in different depths of the system, leading to Pareto-optimal solutions. We state a sound and complete algorithm that not only tackles the optimization problem but moreover verifies whether a global optimum has been identified by using a complete BMC solver as back-end. As a first reference application we present the problem of circuit initialization. Additionally, we give pointers to other tasks which can be covered by our formalism quite naturally and further demonstrate the efficiency and effectiveness of our approach.
El autoconcepto físico y el bienestar-malestar psicológico en la adolescencia

El autoconcepto fisico, en cuanto dominio independiente del autoconcepto general, empieza a ser objeto de estudio a partir de los anos noventa del pasado siglo, conociendose su asociacion con la practica deportiva y con imagen corporal o sus cambios en funcion del sexo y de la edad. En cambio, nada se habia indagado sobre las relaciones que guarda el autoconcepto fisico con el bienestar y con el malestar psicologicos; de ahi la novedad y originalidad de la tematica de esta tesis. Se trata de un estudio, de caracter basicamente correlacional, con tres objetivos fundamentales: estudiar la relacion entre el autoconcepto fisico y el bienestar psicologico, identificar la relacion entre el autoconcepto fisico y la ansiedad y depresion, y analizar las relaciones entre el autoconcepto fisico y los trastornos alimentarios. Participaron en el estudio 1959 sujetos adolescentes de entre 12 y 23 anos, de los cuales 48 son pacientes diagnosticadas de algun tipo de trastorno de la conducta alimentaria. Se relacionan las respuestas dadas al Cuestionario de Autoconcepto Fisico (CAF), de Goni, Ruiz de Azuz y Rodriguez (2006) con: a) las respuestas a los cuestionarios EBP, PNA, SWLS y SLSW para la evaluacion del bienestar y sus dimensiones; b) las respuestas a las escalas STAI, BDI y CDI para la medicion de la ansiedad y la depresion; y c) las respuestas al EDI-2 para el examen del riesgo de trastornos de la conducta alimentaria. Los datos obtenidos indican que el autoconcepto fisico guarda una relacion de signo positivo con el bienestar psicologico y una relacion negativa con el malestar psicologico, de tal forma que cuanto mas elevado sea el yo-fisico percibido, mayor bienestar experimenta la persona, menores niveles de ansiedad y depresion o menor riesgo posee de padecer un trastorno de la conducta alimentaria presenta. Tambien se han analizado esas relaciones en funcion de variables como la edad, el genero o la actividad fisico-deportiva, encontrandose, como norma general, que los adolescentes varones frente a las mujeres, los adolescentes de 12-14 anos frente a los de 15-17 anos o a los mayores de 18 anos, y los que hacen actividad fisica frente a quienes no la hacen, ofrecen unas puntuaciones mas elevadas en bienestar psicologico asociado al autoconcepto fisico, y unas puntuaciones menores en malestar psicologico relacionado con el yo-fisico percibido. Estas relaciones permiten identificar la capacidad predictiva del autoconcepto fisico sobre el malestar asi como su incidencia sobre el bienestar psicologico, y sus relaciones con los trastornos de la conducta alimentaria en pacientes diagnosticadas de anorexia o bulimia nerviosa.
Reactive Hyperemia Occurs Via Activation of Inwardly Rectifying Potassium Channels and Na+/K+-ATPase in Humans

Rationale: Reactive hyperemia (RH) in the forearm circulation is an important marker of cardiovascular health, yet the underlying vasodilator signaling pathways are controversial and thus remain unclear. Objective: We hypothesized that RH occurs via activation of inwardly rectifying potassium (KIR) channels and Na+/K+-ATPase and is largely independent of the combined production of the endothelial autocoids nitric oxide (NO) and prostaglandins in young healthy humans. Methods and Results: In 24 (23±1 years) subjects, we performed RH trials by measuring forearm blood flow (FBF; venous occlusion plethysmography) after 5 minutes of arterial occlusion. In protocol 1, we studied 2 groups of 8 subjects and assessed RH in the following conditions. For group 1, we studied control (saline), KIR channel inhibition (BaCl2), combined inhibition of KIR channels and Na+/K+-ATPase (BaCl2 and ouabain, respectively), and combined inhibition of KIR channels, Na+/K+-ATPase, NO, and prostaglandins (BaCl2, ouabain, L-NMMA [NG-monomethyl-L-arginine] and ketorolac, respectively). Group 2 received ouabain rather than BaCl2 in the second trial. In protocol 2 (n=8), the following 3 RH trials were performed: control; L-NMMA plus ketorolac; and L-NMMA plus ketorolac plus BaCl2 plus ouabain. All infusions were intra-arterial (brachial). Compared with control, BaCl2 significantly reduced peak FBF (−50±6%; P<0.05), whereas ouabain and L-NMMA plus ketorolac did not. Total FBF (area under the curve) was attenuated by BaCl2 (−61±3%) and ouabain (−44±12%) alone, and this effect was enhanced when combined (−87±4%), nearly abolishing RH. L-NMMA plus ketorolac did not impact total RH FBF before or after administration of BaCl2 plus ouabain. Conclusions: Activation of KIR channels is the primary determinant of peak RH, whereas activation of both KIR channels and Na+/K+-ATPase explains nearly all of the total (AUC) RH in humans.
Improving mixed-single SOC testing: a power-aware reuse-based approach with analog BIST

Analog BIST and SoC testing are two topics that have been extensively, but independently, studied in the last few years. However, current mixed-signals systems require the combination of these subjects to generate a cost-effective test solution for the whole SoC. This paper discusses the impact on the global system testing time of an analog BIST method based on digital reuse. Experimental results show that the reuse of digital blocks to test analog signals is indeed a very efficient strategy, even under power constraints, as long as the BIST technique reduces the analog testing time.
Successful use of etanercept in a case of toxic epidermal necrolysis induced by rituximab

and triglycerides in asteatotic eczema. Pemetrexed predominantly inhibits thymidylate synthetase and other folate enzymes, which are involved in the synthesis of purines and pyrimidines. To the best of our knowledge, these enzymes were not implicated in the epidermal lipids nor in sebum production. Xerosis and eczema craquel e were not associated with folate deficiency and other antifolate drugs (e.g. methotrexate, trimethoprim). Therefore, we postulate that this rare skin toxicity is not directly related to the antifolate mechanism. In conclusion, our case demonstrated that generalized eczema craquel e can be induced by pemetrexed. Further investigation (e.g. patch test) is needed to elucidate the underlying pathomechanism.
Relation between Delayed Superfluous Insulin Secretion during An Oral Glucose Tolerance Test and Metabolic Disorders in Obese Japanese Children

The aim of this study was to clarify the relation between postprandial hyperinsulinemia and metabolic disorders in obese children. Twenty-eight obese Japanese children (8.8–16.2 yr) were divided into four groups: without impaired liver function and dyslipidemia (Group A), with impaired liver function (Group B), with dyslipidemia (Group C), and with impaired liver function and dyslipidemia (Group D). The levels of PG, serum immunoreactive insulin (IRI) and serum C-peptide (CPR) were measured during an oral glucose tolerance test (OGTT). The subjects had delayed superfluous insulin and CPR secretion during the OGTT compared with healthy references. In regard to the insulin secretion pattern, Group A’s response peaked at 60 min and then decreased gradually until 120 min, Group B’s response peaked at 60 min, remained at the peak until 120 min and then decreased gradually until 180 min, Group C’s response peaked at 120 min and then decreased gradually until 180 min, and Group D’s response peaked at 120 min and remained at the peak until 180 min. These results suggest that delayed superfluous insulin secretion during an OGTT is related to metabolic disorders in obese Japanese children and that these patients will experience a vicious cycle of postprandial hyperinsulinemia and metabolic disorders. It is important to prevent healthy children from becoming obese and to improve management of childhood obesity.
Cloning and functional expression of rat ether‐à‐go‐go‐like K+ channel genes

1 Screening of rat cortex cDNA resulted in cloning of two complete and one partial orthologue of the Drosophilaether‐à‐go‐go‐like K+ channel (elk). 2 Northern blot and reverse transcriptase‐polymerase chain reaction (RT‐PCR) analysis revealed predominant expression of rat elk mRNAs in brain. Each rat elk mRNA showed a distinct, but overlapping expression pattern in different rat brain areas. 3 Transient transfection of Chinese hamster ovary (CHO) cells with rat elk1 or rat elk2 cDNA gave rise to voltage‐activated K+ channels with novel properties. 4 RELK1 channels mediated slowly activating sustained potassium currents. The threshold for activation was at −90 mV. Currents were insensitive to tetraethylammonium (TEA) and 4‐aminopyridine (4‐AP), but were blocked by micromolar concentrations of Ba2+. RELK1 activation kinetics were not dependent on prepulse potential like REAG‐mediated currents. 5 RELK2 channels produced currents with a fast inactivation component and HERG‐like tail currents. RELK2 currents were not sensitive to the HERG channel blocker E4031.
Noise source separation based on the blind source separation

The identification of acoustic source accurately is a fundamental problem in noise control. In the practical project, if the contribution of multi-source-noise to the whole was identified, and then the noise level can be reduced accordingly. To get the accurate noise signal, measurements should be possible while the machines are constantly in action. It is easier to get the mixed signals rather than individual ones. The way to separate the individual signals from the mixed ones is needed in this situation. In our paper Blind Source Separation (BSS) based on temporal predictability (James V. Stone 2001) was used to get the independent individual noise source signals. The results of simulation signals confirmed the feasibility and validity of BSS method in noise source separation and it will play an important role in noise identification, signal source identification and other fields.
A Computational Model of Narrative Generation for Suspense

The generation of stories by computers, with applications ranging from computer games to education and training, has been the focus of research by computational linguists and AI researchers since the early 1970s. Although several approaches have shown promise in their ability to generate narrative, there has been little research on the generation of stories that evoke specific cognitive and affective responses in their readers. The goal of this research is to develop a system that produces a narrative designed specifically to evoke a targeted degree of suspense, a significant contributor to the level of engagement experienced by users of interactive narrative systems. The system that I present takes as input a plan data structure representing the goals of a storyworld's characters and the actions they perform in pursuit of them. Adapting theories developed by cognitive psychologists, my system uses a plan-based model of narrative comprehension to determine the final content of the story in order to manipulate a reader's level of suspense in specific ways. In this thesis, I outline the various components of the system and describe an empirical evaluation that I used to determine the efficacy of my techniques. The evaluation provides strong support for the claim that the system is effective in generating suspenseful stories.
What is it like to take care of the land? Toward an understanding of private land conservation

Abstract Land conversion for agriculture, residential developments and infrastructure expansion is one of the main problems in environmental conservation. Government policies for public lands alone are unlikely to stem these dynamics. It is increasingly recognized that private land conservation is an essential part of environmental protection and especially properties of non-farm, private landowners are interesting for conservation purposes. However, non-farm, private landowners are less likely to respond to traditional motivators for environmental conservation and little is known about the conservation attitudes and values of this group. To gain a better understanding of private land conservation, the current study explored the relationships of 13 non-farm, private landowners with their land and its natural environment. Interpretive Phenomenological Analysis was used as the approach because of its practical ability to reveal how personal contexts and experiences shape these relationships and how personal meaning is created. The results indicate that private landowners can have strong, affective relationships with their land that are associated with childhood histories of rural living and the enjoyment of natural spaces. These relationships increase quality of life, give a sense of belonging, and motivate a desire to protect the land against environmental degradation. The present private landowners expressed a well-developed conservation ethic. However, future conservation approaches for these properties are less clear, but might be achieved through conservation easement programs.
Tikkun Olam : how a Jewish ethos drives innovation

Purpose – The purpose of this paper is to argue that the Jewish religious concept “Tikkun Olam” is a source of practical management wisdom. “Tikkun Olam” combines with the diaspora and the state of Israel's specific political and economic contexts to provide Jewish people with an important driver and legitimization tool to change the world for the better. Since science and technology innovation has become a powerful tool to impact on today's world, “Tikkun Olam” builds on this profane channel for its present expression and supports the involvement of Jewish people in this matter.Design/methodology/approach – To substantiate this view, the author analyzes the historical trajectories of the state of Israel and the Jewish diaspora. Some evidence is provided to highlight their specific dynamics and assets for knowledge creation, accumulation and transfer. Drawing on the academic literature, the author discusses what could be Jewish specificities on that matter compared with other nations and diasporas.Finding.
Shugoshin and PP2A, shared duties at the centromere.

Sister chromatid cohesion mediated by the ring-shaped cohesin complex is essential for faithful chromosome segregation. A tight spatial and temporal control of cohesin release is observed in mitosis and meiosis, and a family of proteins known as shugoshins play a major role in this process. Shugoshin (Sgo) protects centromeric cohesin from dissociation in early mitosis and from cleavage by separase in meiosis I. Three exciting new reports indicate that this is accomplished by recruiting the serine/threonine protein phosphatase 2A (PP2A) to centromeres. ((1-3)) The proposed targets of PP2A activity include cohesin and Sgo, both of which would otherwise dissociate from chromosomes upon phosphorylation by Polo kinase. Thus, a balance of kinase and phosphatase activities seems to be the key to the conserved mechanism that regulates the stepwise release of cohesin from mitotic and meiotic chromosomes. Additional evidence, however, suggests that this is only part of the story, and that Sgo has also a role independent of PP2A.
Systematic identification of tRNAome and its dynamics in Lactococcus lactis

Transfer RNAs (tRNAs) through their abundance and modification pattern significantly influence protein translation. Here, we present a systematic analysis of the tRNAome of Lactococcus lactis. Using the next‐generation sequencing approach, we identified 40 tRNAs which carry 16 different post‐transcriptional modifications as revealed by mass spectrometry analysis. While small modifications are located in the tRNA body, hypermodified nucleotides are mainly present in the anticodon loop, which through wobbling expand the decoding potential of the tRNAs. Using tRNA‐based microarrays, we also determined the dynamics in tRNA abundance upon changes in the growth rate and heterologous protein overexpression stress. With a fourfold increase in the growth rate, the relative abundance of tRNAs cognate to low abundance codons decrease, while the tRNAs cognate to major codons remain mostly unchanged. Significant changes in the tRNA abundances are observed upon protein overexpression stress, which does not correlate with the codon usage of the overexpressed gene but rather reflects the altered expression of housekeeping genes.
Isl1 and Ldb Co‐regulators of transcription are essential early determinants of mouse limb development

Background: The developing limb has served as an excellent model for studying pattern formation and signal transduction in mammalians. Many of the crucial genes that regulate growth and patterning of the limb following limb bud formation are now well known. However, details regarding the control of limb initiation and early stages of outgrowth remain to be defined. This report is focused on genetic events that pave the way for the establishment of a hindlimb bud. Results: Fgf10 and Tbx are crucial for early phases of limb bud initiation. Here we show that in the absence of Isl1 or of Ldb1/2, there is no hindlimb bud development. Fgf10 expression in the bud mesenchyme is dependent on Isl1 and its Ldb co‐regulators. Conclusions: Thus, Isl1 and the Ldb co‐regulators of transcription are essential early determinants of mouse limb development. Isl1/Ldb complexes regulate Fgf10 to orchestrate the earliest stages of hindlimb formation. Developmental Dynamics 241:787–791, 2012. Published 2012 Wiley Periodicals, Inc.
Inhibition of return

Immediately following an event at a peripheral location there is facilitation for the processing of other stimuli near that location. This is said to reflect a reflexive shift of attention towards the source of stimulation. After attention is removed from such a peripheral location, there is then delayed responding to stimuli subsequently displayed there. This inhibitory aftereffect, first described in 1984 and later labeled 'inhibition of return (IOR)', encourages orienting towards novel locations and hence might facilitate foraging and other search behaviors. Since its relatively recent discovery, IOR has been the subject of intensive investigation, from many angles and with a wide variety of approaches. After describing the seminal contribution of Posner and Cohen ('Who'), this review will discuss what causes IOR and, once initiated, what effects IOR has on subsequent processing ('What'). The time course ('When') and spatial distribution ('Where') of IOR, and what is known about IOR's neural implementation ('How') and functional significance ('Why') are also discussed.
Individual Differences, Auditory Imagery, and the Coordination of Body Movements and Sounds in Musical Ensembles

The Role of Anticipatory Auditory Imagery in musical ensemble performance was investigated by examining the relationship between individual differences in auditory imagery and temporal coordination in piano duos. Vividness of imagery for upcoming sounds was assessed in 14 pianists using a task that required the production of rhythmic sequences with or without auditory feedback. Ensemble coordination was assessed by examining temporal relations between body movements (recorded by a motion capture system) and sound onsets (triggered by key strokes on two MIDI pianos) in seven duos playing two contrasting pieces with or without visual contact. Sound synchrony was found to be related to anterior-posterior body sway coordination in a manner that depended upon leader/follower relations between pianists assigned to 9primo9 and 9secondo9 parts. Furthermore, the quality of coordination, which was not affected markedly by whether pianists were in visual contact, was correlated with individual differences in anticipatory auditory imagery. These findings suggest that auditory imagery facilitates interpersonal coordination by enhancing the operation of internal models that simulate one9s own and others9 actions during ensemble performance.
Predicting intercultural competence in educational settings: the validity, reliability and utility of two instruments

Abstract Determining individual potential for performance within multicultural environments is important in the increasingly globalised workplace. The Multicultural Personality Questionnaire (MPQ) and the Self-Efficacy Questionnaire (SEQ) aim to measure such professional effectiveness. In a study using student and faculty samples in an international educational context, the reliability and validity of both inventories were examined, as was the ability of the MPQ to discriminate between those with and without international work-based aspirations. The MPQ demonstrated some limited potential for identifying multicultural effectiveness. However, data gathered did not support previous claims for the predictive value of the MPQ or for the ability of either instrument to discriminate between disparate samples. The implications for the use of these and other instruments are discussed.