Miracle-dz/UniFAR-FTUs huggingface dataset:
When Overexpressed, a Novel Centrosomal Protein, RanBPM, Causes Ectopic Microtubule Nucleation Similar to γ-Tubulin

A novel human protein with a molecular mass of 55 kD, designated RanBPM, was isolated with the two-hybrid method using Ran as a bait. Mouse and hamster RanBPM possessed a polypeptide identical to the human one. Furthermore, Saccharomyces cerevisiae was found to have a gene, YGL227w, the COOH-terminal half of which is 30% identical to RanBPM. Anti-RanBPM antibodies revealed that RanBPM was localized within the centrosome throughout the cell cycle. Overexpression of RanBPM produced multiple spots which were colocalized with γ-tubulin and acted as ectopic microtubule nucleation sites, resulting in a reorganization of microtubule network. RanBPM cosedimented with the centrosomal fractions by sucrose- density gradient centrifugation. The formation of microtubule asters was inhibited not only by anti- RanBPM antibodies, but also by nonhydrolyzable GTP-Ran. Indeed, RanBPM specifically interacted with GTP-Ran in two-hybrid assay. The central part of asters stained by anti-RanBPM antibodies or by the mAb to γ-tubulin was faded by the addition of GTPγS-Ran, but not by the addition of anti-RanBPM anti- bodies. These results provide evidence that the Ran-binding protein, RanBPM, is involved in microtubule nucleation, thereby suggesting that Ran regulates the centrosome through RanBPM.
From the Editors-Elect: Meaningful Consumer Research

We are honored, humbled, and excited to have been entrusted with the editorship of the Journal of Consumer Research ( JCR ) as it enters its fifth decade of publication. Ushered into existence 40 years ago in June 1974, this journal was born in a time of intellectual ferment that has been likened to the “Mississippi River in flood stage” by founding editor Ronald Frank (1995, 486). Motivated by dissatisfaction with what were perceived as restrictive visions in other publication outlets and a shared conviction that there was a need to foster research that provided a deeper understanding of a fuller gamut of consumer behavior, the founders expressed bold ambitions. They sought to create a journal in which scholars interested in a spectrum of consumer behavior, construed in the broadest of terms, could be published. They intended that JCR should be “the first journal in which professionals sharing an interest in consumer behavior across disciplines send their material” (Frank 1974, i). And they believed that interdisciplinary research should be promoted. While the notion that the journal should publish impactful papers was largely implicit at the time of the founding, fostering high-impact research has become an explicit, complementary goal in the intervening years. Thus, the mandate we inherit is tripartite: publish work on the broad spectrum of consumer behavior, publish work that contributes to conversations across a range …
Improving Deterministic and Randomized Exponential-Time Algorithms for the Satisfiability, the Colorability, and the Domatic Number Problem

NP-complete problems cannot have efficient algorithms unless P = NP. Due to their importance in practice, however, it is useful to improve the known expo- nential-time algorithms for NP-complete problems. We survey some of the recent results on such improved exponential-time algorithms for the NP-complete problems satisfi- ability, graph colorability, and the domatic number problem. The deterministic time bounds are compared with the corresponding time bounds of randomized algorithms, which often run faster but only at the cost of having a certain error probability.
INDUCTION OF PARTIAL IMMUNOLOGIC TOLERANCE IN RATS AND PROGRESSIVE LOSS OF CELLULAR ANTIGENICITY IN GROSS VIRUS LYMPHOMA

Gross virus-induced lymphoma cells express strong virus-associated (Gross murine leukemia virus [G-MuLV]) antigens and are consistently rejected when grafted in normal adult syngeneic rats. By contrast, similar grafts are tolerated and allowed to grow progressively by rats that have been injected at birth with deaggregated G-MuLV antigens. However, the tolerance induced by this procedure is only partial as the grafted lymphoma cells lose their G-MuLV membrane antigens. These cells showing an antigenic disjunction, with negative membrane and positive cytoplasmic G-MuLV antigenic expression, become transplantable in normal-nonconditioned adult recipients. By further grafting, the expression of cytoplasmic G-MuLV antigens is similarly lost while the lymphoma cells substantially increase their transplantability, rate of growth, and capacity for metastasis.
Meta-analysis: Effect of Interactive Communication Between Collaborating Primary Care Physicians and Specialists

BACKGROUND Whether collaborative care models that enable interactive communication (timely, 2-way exchange of pertinent clinical information directly between primary care and specialist physicians) improve patient outcomes is uncertain. PURPOSE To assess the effects of interactive communication between collaborating primary care physicians and key specialists on outcomes for patients receiving ambulatory care. DATA SOURCES PubMed, PsycInfo, EMBASE, CINAHL, Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, and Web of Science through June 2008 and secondary references, with no language restriction. STUDY SELECTION Studies that evaluated the effects of interactive communication between collaborating primary care physicians and specialists on outcomes for patients with diabetes, psychiatric conditions, or cancer. DATA EXTRACTION Contextual, intervention, and outcome data from 23 studies were extracted by one reviewer and checked by another. Study quality was assessed with a 13-item checklist. Disagreement was resolved by consensus. Main outcomes for analysis were selected by reviewers who were blinded to study results. DATA SYNTHESIS Meta-analysis indicated consistent effects across 11 randomized mental health studies (pooled effect size, -0.41 [95% CI, -0.73 to -0.10]), 7 nonrandomized mental health studies (pooled effect size, -0.47 [CI, -0.84 to -0.09]), and 5 nonrandomized diabetes studies (pooled effect size, -0.64 [CI, -0.93 to -0.34]). These findings remained robust to sensitivity analyses. Meta-regression indicated studies that included interventions to enhance the quality of information exchange had larger effects on patient outcomes than those that did not (-0.84 vs. -0.27; P = 0.002). LIMITATIONS Because collaborative interventions were inherently multifaceted, the efficacy of interactive communication by itself cannot be established. Inclusion of study designs with lower internal validity increased risk for bias. No studies involved oncologists. CONCLUSION Consistent and clinically important effects suggest a potential role of interactive communication for improving the effectiveness of primary care-specialist collaboration. PRIMARY FUNDING SOURCE RAND Health's Comprehensive Assessment of Reform Options Initiative, the Veterans Affairs Center for the Study of Provider Behavior, The Commonwealth Fund, and the Health Foundation.
Prime-Time Violence 1993-2001: Has the Picture Really Changed?

Violence remained stable in prime-time network programs broadcast between the spring of 1993 and the fall of2001 and similar to levels found in studies of the 1970s and 1980s. Violence appeared in 6 out of 10 programs, at a rate of 4.5 acts per program. Violence was context-free. There was little gratuitous or graphic violence, few characters were punished for their involvement in violence, and few overall consequences. The lack of context may teach that violence is "sanitary," not necessarily immoral, and that those who commit violence are not sorry for their actions, or punished for their transgressions.
Please Scroll down for Article International Journal of Electronics Building a Multi-fpga-based Emulation Framework to Support Networks- On-chip Design and Verification Qingdong(2010) 'building a Multi-fpga-based Emulation Framework to Support Networks-on-chip Design and Building a Multi-fpga-based 

This article may be used for research, teaching and private study purposes. Any substantial or systematic reproduction, redistribution , reselling , loan or sub-licensing, systematic supply or distribution in any form to anyone is expressly forbidden. The publisher does not give any warranty express or implied or make any representation that the contents will be complete or accurate or up to date. The accuracy of any instructions, formulae and drug doses should be independently verified with primary sources. The publisher shall not be liable for any loss, actions, claims, proceedings, demand or costs or damages whatsoever or howsoever caused arising directly or indirectly in connection with or arising out of the use of this material. In this article, we present a highly scalable, flexible hardware-based network-on-chip (NoC) emulation framework, through which NoCs built upon various types of network topologies, routing algorithms, switching protocols and flow control schemes can be explored, compared, and validated with injected or self-generated traffic from both real-life and synthetic applications. This high degree of scalability and flexibility is achieved due to the field programmable gate array (FPGA) design choices made at both functional and physical levels. At the functional level, a NoC system to be emulated can be partitioned into two parts: (i) the processing cores and (ii) the network. Each part is mapped onto a different FPGA so that when there is any change to be made to any one of these parts, only the corresponding FPGA needs to be reconfigured and the rest of the FPGAs will be left untouched. At the physical level, two levels of interconnects are adopted to mimic NoC on-chip communications: high bandwidth and low latency parallel on-board wires, and high-speed serial multigigabit transceivers available in FPGAs. The latter is particularly important as it helps the proposed NoC emulation platform scale well with the size increase of the NoCs. 1. Introduction In future many-core system on chip (SoC) designs, on-chip interconnect links between cores will have significant effects on the overall system performance and power consumption. In these SoCs with tens or even hundreds of cores integrated either onto a single integrated circuit die, or onto multiple dies in a single chip package, traditional interconnection techniques using a bus topology or dedicated wires are no longer feasible due to insufficient data bandwidth and poor scalability. As a viable alternative, the network-on-chip (NoC) paradigm has been proposed as an enabling replacement …
Referring Expressions and Communicative Success in Task-oriented Dialogues

This paper studies lexical and structural properties of coreference chains in task-oriented dialogue and investigates their relationship with perceived and factual com-municative success. In line with previous literature, our quantitative analysis shows that lexical entrainment is the most reliable predictor of task success, among the ones we compute. But also that there is a complex relationship between these factors – for example, neither high nor low, but rather intermediate levels of lexical alignment predict high perceived and factual success.
RSSI-Based Multi-Target Tracking by Cooperative Agents Using Fusion of Cross-Target Information

In this paper we present a new approach to Received-Signal-Strength-Indicator (RSSI)-based multi-target tracking. In order to effectively deal with this inherently high-dimensional problem, the approach leverages space decomposition through cooperative distributed processing. The core system is composed of multiple agents where each agent is assigned to track a particular target. The agents exchange information, and based on it they treat the RSSI from the targets they do not track as measurement interference. We present computer simulations that compare the new method with conventional approaches in settings with two and 20 targets, respectively. They demonstrate the improvements of the proposed method in tracking a relatively large number of targets.
Writing your first successful grant application to conduct communication research

Advice is offered to help scholars write successful communication grant applications, including practical issues such as learning about opportunities, finding the time to write, planning personnel, budgeting, negotiating internal resources, institutional review boards, and deliverables. Additional tips are offered on theoretically rich research with socially meaningful applied outcomes, counterintuitive mechanisms and outcomes, simplicity, detail orientation, demonstrating expertise in the content area, and demonstrating expertise with the population under investigation. Finally, we mention some important traits for getting through the review process-persistence and low ego-involvement.
Establishing Dedicated Functions on FPGA Devices for High-Performance Cryptography

This work presents a unique design approach to implement standardized symmetric and asymmetric cryptosy stems on modern FPGA devices. While most other FPGA implementations optimize cryptosystems on an algorithmic level for being optimally placed in the generic logic, our primary goal is to shift as many cryptographic operations as possible into specific hard cores that have become available on modern reconfigurable devices. Such dedicated functions provide, for example, large blocks of memory or accelerated arithmetic functions for digital signal processing applic ations. Using these dedicated function, we present specific design approaches that enable a performance for the symmetric AES block cipher (FIPS 197) of up to 55 GBit/s and a throughput of more than 30.000 scalar multiplications per second for asymmetric Elliptic Curve Cryptography over NIST’s P-224
Der Einfluß der Umweltpolitik auf das Innovationsverhalten eine ökonometrische Untersuchung

Im Beitrag werden, basierend auf den Daten des Mannheimer Innovationspanels 1993, die Einflusfaktoren umweltorientierter Innovationen in Deutschland in einem multivariaten Kontext okonometrisch untersucht. Ziel ist es, sowohl allgemeine Strukturen der Einflusfaktoren von Umweltinnovationen zu analysieren, als auch den spezifischen Einflus umweltpolitischer Instrumente innerhalb dieses Faktorensystems abzuschatzen. Der Handlungsdruck umweltpolitischer Instrumente auf das Innovationsverhalten von Unternehmen wird durch Regulierungsindikatoren abgebildet, die in einer schriftlichen Erhebung bei den deutschen Industrie und Handelskammern ermittelt wurden. Aufgrund der Komplexitat der Einflusfaktoren und der Schwierigkeiten, die Wirkung umweltpolitischer Instrumente zu isolieren, ist die vorliegende Untersuchung in methodischer und empirischer Hinsicht eine explorative Arbeit. ; This paper examines the determinants, that influence the environmental innovation behaviour of companies in Germany in a multivariate context, by using data from the Mannheimer Innovationspanel 1993. The objective is to analyse the general structures of the determinants of environmental innovation, as well as the specific impact of environmental policy instruments as an integral part of this framework. The pressure of environmental policy instruments on the innovation behaviour of companies is reproduced by indicators, which are investigated in a written survey at the level of the German Chambers of Commerce. Because of the complexity of the system of determinants and the difficulties in isolating the effects of environmental policy instruments, the study in hand is an explorative work in a methodological and empirical matter.
Challenges Faced by Minority Children in Obtaining Dental Care

Deaths of children due to neglected dental diseases have put the issue of access to care by minorities at the forefront of dental public health discussions. We evaluated the trends in dental service utilization in relation to racial disparities and other factors using Medicaid enrollment and claims data from 1990 to 1997 for Alabama children 19 years of age and younger (N=512,049). Alabama Medicaid children visited the dentist at a low and declining rate. The number of participating providers gradually declined over time and the racial disparities in service utilization were related to the availability of a local provider. Lower service utilization, however, was not a simple function of race, but a complex interaction of race with age and gender. Identification of these complex interactions and removal of barriers to service utilization in race, age, and gender sub-groups will help the U.S. meet the year 2010 oral health objectives.
Additive subordination and its applications in finance

This paper studies additive subordination, which we show is a useful technique for constructing time-inhomogeneous Markov processes with analytical tractability. This technique is a natural generalization of Bochner’s subordination that has proved to be extremely useful in financial modeling. Probabilistically, Bochner’s subordination corresponds to a stochastic time change with respect to an independent Lévy subordinator, while in additive subordination, the Lévy subordinator is replaced by an additive one. We generalize the classical Phillips theorem for Bochner’s subordination to the additive subordination case, based on which we provide Markov and semimartingale characterizations for a rich class of jump-diffusions and pure jump processes obtained from diffusions through additive subordination, and obtain spectral decomposition for them. To illustrate the usefulness of additive subordination, we develop an analytically tractable cross-commodity model for spread option valuation that is able to calibrate the implied volatility surface of each commodity. Moreover, our model can generate implied correlation patterns that are consistent with market observations and economic intuitions.
Political Processes and Local Newspaper Coverage of Protest Events: From Selection Bias to Triadic Interactions1

Political processes affect both protest and news coverage of protest, but past research has failed to examine these interactions. Data from one city reveal the interaction of political process, news value, and news routine factors in news coverage of protest versus other message events. Protests about legislative issues received the most coverage. Controlling for issue type, protest forms were covered less when the legislature was in session, while other forms (largely ceremonies and speeches) were covered more. Yearly variations in coverage rates of nonlegislative protests distorted the apparent shape of the protest cycle. Other predictive factors include size, police involvement, conflict, counterdemonstrators, amplified sound, Monday event, religious sponsorship (negative), and annual or holiday event.
Formal Mentoring Programs: A Mentor-Centric and Longitudinal Analysis

Formal mentoring programs are becoming more popular as organizations attempt to reap the benefits that have long been associated with informal mentoring. The present study adds to the small number of mentor-centric studies and offers a unique longitudinal examination of formal mentoring programs. Findings suggest that as formal mentoring relationships develop over time, mentors begin to use their time more efficiently and the negative effects of cross-gender differences dissipate. Furthermore, whereas mentor reports of psychosocial support and role modeling appear to relate to mentor program satisfaction and protégé reports of mentor effectiveness, reports of vocational support appear to have no impact on these variables. Study limitations are discussed, and implications for future research and for practice are suggested.
Determinantes sociais do desmame: contribuições das diferentes abordagens metodológicas

O objetivo deste trabalho foi estudar as contribuicoes dos metodos quantitativos e qualitativos para a construcao do conhecimento acerca dos determinantes sociais do processo de desmame, atraves da comparacao entre os achados de pesquisas publicadas entre 2003 e 2009 na base de dados do sistema LILACS. Os determinantes sociais identificados nas investigacoes quantitativas foram expressos por variaveis de risco, enquanto os identificados nas investigacoes qualitativas deram visibilidade aos fatores intersubjetivos e objetivos que estruturam a acao social. O entendimento de que quantidade e qualidade sao caracteristicas que compoem os fenomenos complexos leva a propor a triangulacao de metodos como uma estrategia para ampliar o conhecimento ja existente acerca dos determinantes sociais do processo de desmame, e, assim, poder contribuir para a ampliacao do periodo de amamentacao.
Manipulation Planning Among Movable Obstacles

This paper presents the resolve spatial constraints (RSC) algorithm for manipulation planning in a domain with movable obstacles. Empirically we show that our algorithm quickly generates plans for simulated articulated robots in a highly nonlinear search space of exponential dimension. RSC is a reverse-time search that samples future robot actions and constrains the space of prior object displacements. To optimize the efficiency of RSC, we identify methods for sampling object surfaces and generating connecting paths between grasps and placements. In addition to experimental analysis of RSC, this paper looks into object placements and task-space motion constraints among other unique features of the three dimensional manipulation planning domain.
A Simplified Immunohistochemical Classification of Skeletal Muscle Fibres in Mouse

The classification of muscle fibres is of particular interest for the study of the skeletal muscle properties in a wide range of scientific fields, especially animal phenotyping. It is therefore important to define a reliable method for classifying fibre types. The aim of this study was to establish a simplified method for the immunohistochemical classification of fibres in mouse. To carry it out, we first tested a combination of several anti myosin heavy chain (MyHC) antibodies in order to choose a minimum number of antibodies to implement a semi-automatic classification. Then, we compared the classification of fibres to the MyHC electrophoretic pattern on the same samples. Only two anti MyHC antibodies on serial sections with the fluorescent labeling of the Laminin were necessary to classify properly fibre types in Tibialis Anterior and Soleus mouse muscles in normal physiological conditions. This classification was virtually identical to the classification realized by the electrophoretic separation of MyHC. This immuno-histochemical classification can be applied to the total area of Tibialis Anterior and Soleus mouse muscles. Thus, we provide here a useful, simple and time-efficient method for immunohistochemical classification of fibres, applicable for research in mouse.