Miracle-dz/UniFAR-FTUs huggingface dataset:
Partnerships, Tourism, and Community Impacts

The issue of collaboration through partnerships is a major theme in the policy-making, planning, and governance of tourism. Although partnerships can enhance policy learning and exchange, promote business activities, and improve community cohesion, they also present certain downsides. This chapter examines tourism partnerships' practices and impacts, by framing partnerships in relation to their institutional and governance arrangements. The chapter starts by examining the rise of tourism partnerships. Then the state of the art in research on partnerships in tourism scholarship is presented. Next, the impacts associated with tourism partnerships' performance are critically discussed. The chapter concludes with an exploration of key questions that researchers could address in the future.
Welfare Effects of Price Discrimination by a Regulated Monopolist

Should a multiproduct monopolist whose "average price" is capped by regulation be allowed to engage in (third-degree) price discrimination? If the cap applies to a price index with weights proportional to demands at uniform prices, then price discrimination benefits consumers as well as the firm. But if -- perhaps more realistically -- it is the firm's average revenue that is capped, then consumers prefer uniform pricing. In this case total output is higher when discrimination is allowed, which increases welfare, but marginal utilities differ across markets, which is inefficient, and the overall effect is ambiguous. A small amount of discrimination is desirable, however. It is better not to allow price discrimination if the price cap is close to the level of marginal cost. The consequences of tightening the price cap when discrimination is allowed are also examined.
International Journal of Hospitality Management Consumers' Pro-environmental Behavior and the Underlying Motivations: a Comparison between Household and Hotel Settings

The present study made a comparison of pro-environmental behavior and the underlying motivations between household and hotel settings. Results of a survey research among 1185 participants showed a behavioral inconsistency between the two settings – participants reported a significantly higher level of pro-environmental behavior in a household setting. Furthermore, the study revealed that while nor-mative motives are the dominant determinant of pro-environmental behavior in a household setting, hedonic motives are the strongest predictor of such behavior in a hotel setting. Theoretical and managerial implications of the inconsistencies in pro-environmental behavior and underlying motivations between the two settings are discussed.
Frogs Jump Forward: Semantic Knowledge Influences the Perception of Element Motion in the Ternus Display

The Ternus effect is a robust illusion of motion that produces element motion at short interstimulus intervals (ISIs; <50 ms) and group motion at longer ISIs (>50 ms). Previous research has shown that the nature of the stimuli (e.g., similarity, grouping), not just ISI, can influence the likelihood of perceiving element or group motion. We examined if semantic knowledge can also influence what type of illusory motion is perceived. In Experiment 1, we used a modified Ternus display with pictures of frogs in a jump-ready pose facing forwards or backwards to the direction of illusory motion. Participants perceived more element motion with the forward-facing frogs and more group motion with the backward-facing frogs. Experiment 2 tested whether this effect would still occur with line drawings of frogs, or if a more life-like image was necessary. Experiment 3 tested whether this effect was due to visual asymmetries inherent in the jumping pose. Experiment 4 tested whether frogs in a “non-jumping,” sedentary pose would replicate the original effect. These experiments elucidate the role of semantic knowledge in the Ternus effect. Prior knowledge of the movement of certain animate objects, in this case, frogs can also bias the perception of element or group motion.
OPTIMAL HARVEST FEEDBACK RULE ACCOUNTING FOR THE FISHING‐UP EFFECT AND SIZE‐DEPENDENT PRICING

Abstract Fishing leads to truncation of a population's age and size structure. However, large‐sized fish are usually more valuable per unit weight than small ones. Nevertheless, these size‐related factors have mostly been ignored in bioeconomic modeling. Here, we present a simple extension to the Gordon–Schaefer model that accounts for variations in mean individual catch weight, and derive the feedback rule for optimal harvest in this setting. As the Gordon–Schaefer model has no population structure, size effects have to be accounted for indirectly. Here we assume a simple negative relationship between fishing effort and mean individual weight, and a positive relationship between mean catch weight and price. The aim is to emulate alterations of size structure in fish populations due to fishing and the influence of size on price per weight unit and eventually, net revenues. This demonstrates, on a general level, how such size‐dependent effects change the patterns of optimal harvest paths and sustainable revenue in single fish stocks. The model shows clear shifts toward lower levels of optimal effort and yield compared to classical models without size effects. This suggests that ignoring body size could lead to misleading assumptions and policies, potentially causing rent dissipation and suboptimal utilization of renewable resources.
Tensor Tympani Motoneurons Receive Mostly Excitatory Synaptic Inputs

The tensor tympani is a middle ear muscle that contracts in two different situations: in response to sound or during voluntary movements. To gain insight into the inputs and neural regulation of the tensor tympani, we examined the ultrastructure of synaptic terminals on labeled tensor tympani motoneurons (TTMNs) using transmission electron microscopy. Our sample of six TTMNs received 79 synaptic terminals that formed 126 synpases. Two types of synapses are associated with round vesicles and form asymmetric junctions (excitatory morphology). One of these types has vesicles that are large and round (Lg Rnd) and the other has vesicles that are smaller and round (Sm Rnd) and also contains at least one dense core vesicle. A third synapse type has inhibitory morphology because it forms symmetric synapses with pleomorphic vesicles (Pleo). These synaptic terminals can be associated with TTMN spines. Two other types of synapse are found on TTMNs but they are uncommon. Synaptic terminals of all types form multiple synapses but those from a single terminal are always the same type. Terminals with Lg Rnd vesicles formed the most synpases per terminal (avg. 2.73). Together, the synaptic terminals with Lg Rnd and Sm Rnd vesicles account for 62% of the terminals on TTMNs, and they likely represent the pathways driving the contractions in response to sound or during voluntary movements. Having a high proportion of excitatory inputs, the TTMN innervation is like that of stapedius motoneurons but proportionately different from other types of motoneurons. Anat Rec, 2013. © 2012 Wiley Periodicals, Inc.
Market Risk of the Fixed Rates Contracts

In this paper we focus on the concept of a discount rate. In [1] one expressed some concerns regarding the models that present randomization of the discount rate. This paper proposed a new approach to the construction of variable deterministic and stochastic interest rates. This approach is based on the concept of forward rate. In [1, 2] we introduced a new analytical model of popular rate LIBOR. This rate is commonly used in the construction of price instruments that include the euro-dollar exchange rate components. LIBOR is by definition is the average deposit rates of the world's major banks. Valuations of the LIBOR is based on survey Alternative construction of the euro-dollar rate contract may use a synthetic approach. This approach follows the model of LIBOR proposed in [1]. The synthetic approach involves the price value, which consists of the price of its constituent components. This interpretation implies that the LIBOR rate to be charged for deposit of one dollar in the risk free Bank at the initial time which then immediately converts it to the British pounds. The resulting amount is invested then in risk-free British bonds for the period of the contract. At the end of this period, cumulated amount is converted back into dollars. Calculated interest rate represents an analytical representation of a dollar deposit to the risk free Bank while LIBOR rate is the average of the top panel of banks. In [2] we synthetically constructed price associated with LIBOR. Hence, the standard modeling of the LIBOR deals with empirical data rather than with its formal definition.
Stem cells and neurological diseases

Abstract. Cells of the central nervous system were once thought to be incapable of regeneration. This dogma has been challenged in the last decade with studies showing new, migrating stem cells in the brain in many rodent injury models and findings of new neurones in the human hippocampus in adults. Moreover, there are reports of bone marrow‐derived cells developing neuronal and vascular phenotypes and aiding in repair of injured brain. These findings have fuelled excitement and interest in regenerative medicine for neurological diseases, arguably the most difficult diseases to treat. There are numerous proposed regenerative approaches to neurological diseases. These include cell therapy approaches in which cells are delivered intracerebrally or are infused by an intravenous or intra‐arterial route; stem cell mobilization approaches in which endogenous stem and progenitor cells are mobilized by cytokines such as granulocyte colony stimulatory factor (GCSF) or chemokines such as SDF‐1; trophic and growth factor support, such as delivering brain‐derived neurotrophic factor (BDNF) or glial‐derived neurotrophic factor (GDNF) into the brain to support injured neurones; these approaches may be used together to maximize recovery. While initially, it was thought that cell therapy might work by a ‘cell replacement’ mechanism, a large body of evidence is emerging that cell therapy works by providing trophic or ‘chaperone’ support to the injured tissue and brain. Angiogenesis and neurogenesis are coupled in the brain. Increasing angiogenesis with adult stem cell approaches in rodent models of stroke leads to preservation of neurones and improved functional outcome. A number of stem and progenitor cell types has been proposed as therapy for neurological disease ranging from neural stem cells to bone marrow derived stem cells to embryonic stem cells. Any cell therapy approach to neurological disease will have to be scalable and easily commercialized if it will have the necessary impact on public health. Currently, bone marrow‐derived cell populations such as the marrow stromal cell, multipotential progenitor cells, umbilical cord stem cells and neural stem cells meet these criteria the best. Of great clinical significance, initial evidence suggests these cell types may be delivered by an allogeneic approach, so strict tissue matching may not be necessary. The most immediate impact on patients will be achieved by making use of the trophic support capability of cell therapy and not by a cell replacement mechanism.
Adaptive feedback rate control for massive MIMO system in LTE

The increased number of antennas for massive MIMO system implies that the quantization codebook size needs to be significantly larger, which increases precoder search complexity accordingly. This paper compares the vertical/horizontal channel characteristics and finds that the vertical channel has a much longer coherence time than the horizontal channel. Based on these results, a two-dimension CSI quantization mechanism is proposed to allow decoupled vertical/horizontal domain quantization. The mechanism allows the vertical domain precoder search to be implemented at a slower rate than the horizontal domain, thereby enabling the network to separately control the feedback rate/granularity in different spatial dimensions. The proposed mechanism achieves significant UE complexity reduction and power consumption without compromising the system performance, demonstrated by realistic system simulation.
The HIV protease inhibitor indinavir impairs sterol regulatory element-binding protein-1 intranuclear localization, inhibits preadipocyte differentiation, and induces insulin resistance.

Protease inhibitors used in the treatment of HIV infection have been causally associated with lipodystrophy and insulin resistance and were shown to alter adipocyte differentiation in cultured cells. We aimed to delineate the mechanism by which indinavir impaired adipocyte function. We report that indinavir altered neither the growth nor insulin sensitivity of 3T3-F442A preadipocytes, nor did it alter the initial step of their differentiation, i.e., clonal proliferation. However, adipose conversion was inhibited by indinavir (by 50-60%), as shown by 1) the decrease in the number of newly formed adipocytes; 2) the lower level of the adipogenic protein markers, sterol regulatory element-binding protein-1 (SREBP-1), peroxisome proliferator-activated receptor-gamma (PPAR-gamma), and the insulin receptor (IR); and 3) the lack of SREBP-1 and PPAR-gamma immunoreactivity in the nucleus of most indinavir-treated cells. Partial adipose conversion also correlated with an accumulation of SREBP-1 at the nuclear periphery and an alteration in its electrophoretic mobility. Defective expression and nuclear localization of PPAR-gamma probably resulted from the decreased level of nuclear SREBP-1. Indinavir also rendered 3T3-F442A adipocytes resistant to insulin for mitogen-activated protein kinase activation at a step distal to IR substrate-1 tyrosine phosphorylation. Hence, indinavir impairs differentiation at an early step of adipose conversion probably involving the process controlling SREBP-1 intranuclear localization.
Open-Circuit Fault Diagnosis in PMSG Drives for Wind Turbine Applications

Condition monitoring and fault diagnosis are currently considered crucial means to increase the reliability and availability of wind turbines and, consequently, to reduce the wind energy cost. With similar goals, direct-drive wind turbines based on permanent magnet synchronous generators (PMSGs) with full-scale power converters are an emerging and promising technology. Numerous studies show that power converters are a significant contributor to the overall failure rate of modern wind turbines. In this context, open-circuit fault diagnosis in the two power converters of a PMSG drive for wind turbine applications is addressed in this paper. A diagnostic method is proposed for each power converter, allowing real-time detection and localization of multiple open-circuit faults. The proposed methods are suitable for integration into the drive controller and triggering remedial actions. In order to prove the reliability and effectiveness of the proposed fault diagnostic methods, several simulation and experimental results are presented.
Estimating the Cost of Switching Rights on Natural Gas Pipelines*

This paper is about the. pricing of contingent services. The immediate problem is this: What is the cost of the right to choose among pipeline and spot market purchases of natural gas? Changes in the regulation of natural gas pipelines created these rights for customers without providing a mechanism for compensating pipelines. Recently the Federal Energy Regulatory Commission recognized this oversight and called for the rights and obligations of pipelines and customers to be stated explicitly in pipeline service agreements. In the future, service agreements that provide switching rights will be sold at a premium to those that do not. This paper shows how techniques of option pricing can be used to estimate the cost of switching rights. The cost depends on the spot and forward prices of gas, the volatility of gas prices, the rate of interest, and any fees or other restrictions on switching. The option pricing framework should prove useful for pricing contingent services in other sectors of the energy industry as well.
Perceived Readiness to Change

Experience tells us that organizational change is chaotic, related to something new and unknown causing lesser sense of security and stability. Thus, the process can be dramatic for both the individual and the organization. When a change is triggered from external events like change of regulations and industry norms another burden of the top management adjustment occurs, which creates additional obstacle in the natural acceptance process which is believed to be vital for any change. These regulations require that organizations respond accordingly by taking measures to ensure that the behavior of employees change so that the desired outcomes are achieved. The goal of our study was to catalogue as many organizational actions as possible associated with perceived organizational readiness or lack of readiness for change and analyze which factors are decision in the process of implementation of the change itself.
Can the Senate Examine the Constitutional Philosophies of Supreme Court Nominees?

In the last 40 years, universal recognition of the Supreme Court's important policy-making role, the prevalence of divided government, and heightened conflict over value-laden issues such as abortion and school prayer have led to ever more elaborate Senate review of Supreme Court nominations (Freund 1988; Ross 1987, 116-23). Senate hearings into nominees' views on constitutional issues comprise the most visible element in the expanded confirmation process. Yet most recent nominees have won Senate approval while revealing little of their legal or political philosophies. As Powe (1976, 893) has concluded, “Senate questioning [of nominees] has proved astonishingly ineffective in eliciting the desired information. ” The ability of nominees to hide their beliefs on vital constitutional questions raises serious doubts about the Senate's ability to give informed consent to presidents' Supreme Court nominations. This article examines confirmation hearings on recent, pre-Clinton Supreme Court nominees to answer two questions. First, given the recognized importance of Supreme Court appointments and the correspondingly systematic scrutiny of nominees, how do nominees get away with revealing so little of their views on vital constitutional issues? Second, given the answers to the first question, can the hearings be reformed so that senators may air a nominee's views more thoroughly and give—or withhold—truly informed consent to these nominations?
Emission regulations in the electricity market : an analysis from consumers, producers and central planner perspectives

In the first part of this thesis, the objective is to identify optimal bidding strategies in the wholesale electricity market. We consider asymmetric producers submitting bids to a system operator. The system operator allocates demand via a single clearing price auction. The highest accepted bid sets the per unit market price payed by consumers. We find a pure Nash equilibrium to the bidding strategies of asymmetric producers unattainable in a symmetric model. Our results show that producers with relatively large capacities are able to exercise market power. However, the market may seem competitive due to the large number of producers serving demand. The objective of the second part of the thesis, is to compare two regulation policies: a fixed transfer price, such as tax regulation, and a permit system, such as cap-and-trade. For this purpose, we analyze an economy where risk neutral manufacturers satisfy price sensitive demand. The objective of the regulation established by the central planner is to achieve an external objective, e.g. reduce pollution or limit consumption of scarce resource. When demand is uncertain, designing these regulations to achieve the same expected level of the external objective results in the same expected consumer price but very different manufacturers’ expected profit and central planner revenue. For instance, our results show that when the firms are price takers, the manufacturers with the worst technology always prefer a tax policy. Interestingly, we identify conditions under which the manufacturers with the cleanest technology benefit from higher expected profit as tax rate increases. In the third part of the thesis, we investigate the impact labeling decisions have on the supply chain. We consider a two stage supply chain consisting of a supplier and a retailer. Demand is considered stochastic, decreasing in price and increasing in a quality parameter, e.g. carbon emissions. The unit production cost for the supplier is increasing in the quality level chosen. We identify two different contracts that maximize the efficiency of the supply chain while allowing the different parties to achieve their objectives individually. Thesis Supervisor: David Simchi-Levi Title: Professor, The Engineering Systems Division and Department of Civil and Environmental Engineering
Loss of the BBSome perturbs endocytic trafficking and disrupts virulence of Trypanosoma brucei

Significance We combine genetics, biochemistry, cell biology, and proteomics to define Bardet–Biedl Syndrome complex (BBSome) composition, location, and function in the deadly parasite Trypanosoma brucei. BBSome mutants have reduced infectivity in mice, and quantitative proteomics identified parasite surface proteome changes that may underlie reduced virulence. To our knowledge, this work presents the first comprehensive study of the BBSome in any microbial pathogen. T. brucei is also among the earliest organisms to have diverged from other eukaryotes, showing deep evolutionary origins of the BBSome. Localization to membranes and vesicles at the flagellar pocket, together with functional analyses and interaction with clathrin and ubiquitin, supports a model whereby the BBSome functions in postendocytic sorting of select surface proteins. Cilia (eukaryotic flagella) are present in diverse eukaryotic lineages and have essential motility and sensory functions. The cilium’s capacity to sense and transduce extracellular signals depends on dynamic trafficking of ciliary membrane proteins. This trafficking is often mediated by the Bardet–Biedl Syndrome complex (BBSome), a protein complex for which the precise subcellular distribution and mechanisms of action are unclear. In humans, BBSome defects perturb ciliary membrane protein distribution and manifest clinically as Bardet–Biedl Syndrome. Cilia are also important in several parasites that cause tremendous human suffering worldwide, yet biology of the parasite BBSome remains largely unexplored. We examined BBSome functions in Trypanosoma brucei, a flagellated protozoan parasite that causes African sleeping sickness in humans. We report that T. brucei BBS proteins assemble into a BBSome that interacts with clathrin and is localized to membranes of the flagellar pocket and adjacent cytoplasmic vesicles. Using BBS gene knockouts and a mouse infection model, we show the T. brucei BBSome is dispensable for flagellar assembly, motility, bulk endocytosis, and cell viability but required for parasite virulence. Quantitative proteomics reveal alterations in the parasite surface proteome of BBSome mutants, suggesting that virulence defects are caused by failure to maintain fidelity of the host–parasite interface. Interestingly, among proteins altered are those with ubiquitination-dependent localization, and we find that the BBSome interacts with ubiquitin. Collectively, our data indicate that the BBSome facilitates endocytic sorting of select membrane proteins at the base of the cilium, illuminating BBSome roles at a critical host–pathogen interface and offering insights into BBSome molecular mechanisms.