Miracle-dz/UniFAR-FTUs huggingface dataset:
Book Review The Loss of Sadness: How Psychiatry Transformed Normal Sorrow into Depressive Disorder By Allan V. Horwitz and Jerome C. Wakefield. 287 pp. New York, Oxford University Press, 2007. $29.95. 978-0-19-531304-8

1. The concept of depression 2. The anatomy of normal sadness 3. Sadness with and without cause: depression from ancient times through the nineteenth century 4. Depression in the twentieth century 5. Depression in the DSM-IV 6. Importing pathology into the community 7. The surveillance of sadness 8. The DSM and biological research about depression 9. The rise of antidepressant drug treatments 10. The failure of the social sciences to distinguish sadness from depressive disorder 11. Conclusion
La influencia del efecto "Uncanny Valley" en el diseño de un robot social

In this present work we propose which features and functionalities we should consider in the design of social robots according to the “Uncanny Valley” effect. This effect, described in the 70s, argues that when robots have a human appearance and a performance very close to reality, they cause a rejection response between individuals. This effect is reflected in a minimum in the valley of the graphic between social acceptability and the degree of human appearance. If in the social robot design is not taken into account this effect, it may cause displeasure in people who must deal with it, as consecuence the rejection will be immediate. To avoid falling into the valley, the robot should either not to look so much like a human, although their communication skills and work were "very human" or, conversely, completely resemble to him. In the second case, it must be guard all the aspects involved in its design to make humans think that it is "one more of them". The article will conduct a review of this new vision of design: “the uncanny valley effect”, explaining where the robots are placed in the graphic, and mention which features make stronger the acceptance of the design.
Smart posterboard: Multi-modal sensing and analysis of poster conversations

Conversations in poster sessions in academic events, referred to as poster conversations, pose interesting and challenging topics on multi-modal signal and information processing. This paper gives an overview of our project on the smart posterboard for multi-modal conversation analysis. The smart posterboard has multiple sensing devices to record poster conversations, so we can review who came to the poster and what kind of questions or comments he/she made. The conversation analysis combines speech and image processing such as head tracking, speech enhancement and speaker diarization. Moreover, we are also investigating high-level indexing of interest and comprehension level of the audience, based on their multi-modal behaviors during the conversation.
Programmeringen intentionala objekt : Nio elevers uppfattningar av programmering

When it comes to the way we work in the postmodern society of today, essential parts of our tasks are connected to computers in one way or another. The Robots in the industry are one example where traditional human work, concretely and physically, has been replaced by programming and supervising processes in the production. These stages of development make new demands on education and recruiting of labors. The recruiting of qualified labors has turned out to be problematic, and even though extensive efforts has been made in order to increase the interest of technological education, the interest is still weak in Sweden.This study presents the research question: What do pupils focus their attention on when describing programming? The study belongs to a survey conducted on how pupils conceptualise when working with programmable construction material during technology lessons. Working with programmable construction material in schools is one example of computer based learning by means of technological components. The aim is to teach students to visualise technology as a phenomenon in society, as well as introducing them to work with computers.The scientific foundation of the study is grounded in the field of life-world phenomenology with methodology prompting in phenomenography. A fundamental concept in phenomenology, as well as in this study, is intentionality. Another central concept is experience as it is used in phenomenography. The purpose is to describe what pupils, year 8 and 9, focus their attentions on when they are programming – what does the students’ intentional object look like when describing a program? The results of the analyses, one can conclude that four qualitatively separate categories of pupils’ intentional object have appeared. The programming is described with focus on: systematic grouping of the program, to remember another solution of program, the movement of the robot or the solution of the task.
Differential rhythmicity: detecting altered rhythmicity in biological data

MOTIVATION Biological rhythms, such as rhythms in gene expression controlled by the cell cycle or the circadian clock, are important in cell physiology. A common type of experiment compares rhythmicity in tissues or cells either kept under different conditions or having different genotypes. Such investigations provide insights into underlying mechanisms as well as functions of rhythms. RESULTS We present and benchmark a set of statistical and computational methods for this type of analysis, here termed differential rhythmicity analysis. The methods detect alterations in rhythm amplitude, phase and signal to noise ratio in one set of measurements compared to another. Using these methods, we compared circadian rhythms in liver mRNA expression in mice held under two different lighting conditions: constant darkness and light-dark cycles, respectively. This analysis revealed widespread and reproducible amplitude increases in mice kept in light-dark cycles. Further analysis of the subset of differentially rhythmic transcripts implied the immune system in mediating ambient light-dark cycles to rhythmic transcriptional activities. The methods are suitable for genome- or proteome-wide studies, and provide rigorous P values against well-defined null hypotheses. AVAILABILITY AND IMPLEMENTATION The methods were implemented as the accompanying R software package DODR, available on CRAN. CONTACT pal-olof.westermark@charite.de SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
INTERACTIONS OF THE COMPLEMENT SYSTEM WITH THE SURFACE AND ENDOTOXIC LIPOPOLYSACCHARIDE OF VEILLONELLA ALCALESCENS

Electron microscopic studies demonstrated that lesions were produced on the endotoxic lipopolysaccharide (LPS) as well as on the cell surface of V. alcalescens after reaction with fresh guinea pig serum. These lesions were approximately 90 A in diameter, and were seen on two characteristic structural entities derived from LPS preparations after incubation with serum. The use of numerous inhibitors, inactivators, and reaction conditions affecting hemolytic C' activity revealed that these lesions were mediated by the C' system. Concomitant with lesion formation, C' was fixed; the effect on classical C'3 activity was pronounced. It is concluded that endotoxic LPS, as contained in the outer three-layered membrane of the bacterial cell, is a substrate for the C' enzymes. It is suggested that certain biological activities of endotoxin may derive from its effects on the C' system.
Adapting Minds: Evolutionary Psychology and the Persistent Quest for Human Nature

Was human nature designed by natural selection in the Pleistocene epoch? The dominant view in evolutionary psychology holds that it was--that our psychological adaptations were designed tens of thousands of years ago to solve problems faced by our hunter-gatherer ancestors. In this provocative and lively book, David Buller examines in detail the major claims of evolutionary psychology - the paradigm popularised by Steven Pinker in The Blank Slate and by David Buss in The Evolution of Desire - and rejects them all. This does not mean that we cannot apply evolutionary theory to human psychology, says Buller, but that the conventional wisdom in evolutionary psychology is misguided. Evolutionary psychology employs a kind of reverse engineering to explain the evolved design of the mind, figuring out the adaptive problems our ancestors faced and then inferring the psychological adaptations that evolved to solve them. Evolutionary psychologists claim many discoveries based on this approach, including the evolutionary rationale for human mate preferences (that males prefer nubile females and females prefer high-status males) and "discriminative parental solicitude" (the idea that stepparents abuse their stepchildren at a higher rate than genetic parents abuse their biological children). In the carefully argued central chapters of Adapting Minds, Buller scrutinises several of evolutionary psychology's most highly publicised "discoveries. " Drawing on a wide range of empirical research, including his own large-scale study of child abuse, he shows that none is actually supported by the evidence. Buller argues that our minds are not adapted to the Pleistocene, but, like the immune system, are continually adapting, over both evolutionary time and individual lifetimes. We must move beyond the reigning orthodoxy of evolutionary psychology to reach an accurate understanding of how human psychology is influenced by evolution. When we do, Buller claims, we will abandon not only the quest for human nature but the very idea of human nature itself.
Essential Lawyering Skills: Interviewing, Counseling, Negotiation, and Persuasive Fact Analysis

An abundance of solid features makes this text a dependable choice for your classroom: - an experienced author team draws upon many years of teaching and writing about lawyering skills - complete coverage of the essential skills -- problem solving, interviewing, counseling, negotiation, and fact analysis -- ensures a comprehensive approach - exceptional coverage of fact analysis (not found in other texts) and the persuasive value of facts - charts illustrate how to organize facts and fact patterns - plenty of examples promote interest, and accessibility, and place topics in context - ethical concerns are discussed throughout the book, where appropriate The Third Edition has been thoroughly updated to provide students with the latest information: - introduces new topics to counseling and negotiation, including decision theory and financial analysis of proposed agreements - introduces new topics to negotiation, including creativity in generating options, drafting deals, and transactional bargaining - provides additional material on narrative theory and legal story-telling - includes a bound-in CD-ROM with a case file and planning exercises for counseling, fact analysis, and negotiation - offers a fully updated Teacher's Manual that includes new and revised exercises
A sensitivity analysis of the dynamics of a population of thermostatically-controlled loads

Load control of populations of thermostatically-controlled loads (TCLs) is considered a promising approach to match generation and consumption in electricity grids from the demand side. However, when these loads become synchronised they present a decaying oscillatory aggregate demand, which results in undesired power peaks. In this paper we describe the nature of these oscillations and develop a list of factors that determine its shape. We perform a sensitivity analysis which allows us to identify important relations between the physical parameters of the TCLs and their aggregate dynamics. Beyond describing fundamental behaviour, these relations can help develop and validate analytical expressions that facilitate control design, enabling the use of TCLs for demand response.
Timing is everything in intracerebral hemorrhage.

To the Editor: Hallevi and coworkers recently reported on the off-label use of rFVIIa in 46 patients with ICH.1 Twenty-four patients received rFVIIa within 3 hours, and 22 within 3 to 4 hours. Volume increase and outcome at discharge were compared with 148 historical controls. The authors did not find a difference in reduction of volume increase between the 0 to 3 and the 3 to 4 hour group. Nor did they find a difference in outcome between the factor VIIa treated and the control patients. They conclude that timing of hemostatic therapy may not have an influence on volume reduction or outcome in ICH patients. We are not as quick to agree with this conclusion, for the following reasons: First, mean volumes were remarkably smaller—only one-third—than volumes that were found in FAST.2 Size of …
Development of Oral Epithelial Cell Line ROE2 with Differentiation Potential from Transgenic Rats Harboring Temperature-Sensitive Simian Virus40 Large T-Antigen Gene

We have developed an immortalized oral epithelial cell line, ROE2, from fetal transgenic rats harboring temperature-sensitive simian virus 40 large T-antigen gene. The cells grew continuously at either a permissive temperature of 33°C or an intermediate temperature of 37°C. At the nonpermissive temperature of 39°C, on the other hand, growth decreased significantly, and the Sub-G1 phase of the cell cycle increased, indicating that the cells undergo apoptosis at a nonpermissive temperature. Histological and immunocytochemical analyses revealed that ROE2 cells at 37°C had a stratified epithelial-like morphology and expressed cytokeratins Krt4 and Krt13, marker proteins for oral nonkeratinized epithelial cells. Global-scale comprehensive microarray analysis, coupled with bioinformatics tools, demonstrated a significant gene network that was obtained from the upregulated genes. The gene network contained 16 genes, including Cdkn1a, Fos, Krt13, and Prdm1, and was associated mainly with the biological process of skin development in the category of biological functions, organ development. These four genes were validated by quantitative real-time polymerase chain reaction, and the results were nearly consistent with the microarray data. It is therefore anticipated that this cell line will be useful as an in vitro model for studies such as physiological functions, as well as for gene expression in oral epithelial cells.
Engineering of mCherry variants with long Stokes shift, red-shifted fluorescence, and low cytotoxicity

MCherry, the Discosoma sp. mushroom coral-derived monomeric red fluorescent protein (RFP), is a commonly used genetically encoded fluorophore for live cell fluorescence imaging. We have used a combination of protein design and directed evolution to develop mCherry variants with low cytotoxicity to Escherichia coli and altered excitation and emission profiles. These efforts ultimately led to a long Stokes shift (LSS)-mCherry variant (λex = 460 nm and λem = 610 nm) and a red-shifted (RDS)-mCherry variant (λex = 600 nm and λem = 630 nm). These new RFPs provide insight into the influence of the chromophore environment on mCherry’s fluorescence properties, and may serve as templates for the future development of fluorescent probes for live cell imaging.
Performance of low density parity check coded continuous phase frequency shift keying (LDPCC‐CPFSK) over fading channels

In this paper, in order to improve bit error performance, bandwidth efficiency and reduction of complexity compared to related schemes such as turbo codes, we combine low density parity check (LDPC) codes and continuous phase frequency shift keying (CPFSK) modulation and introduce a new scheme, called ‘low density parity check coded‐continuous phase frequency shift keying (LDPCC‐CPFSK)’. Since LDPC codes have very large Euclidean distance and use iterative decoding algorithms, they have high error correcting capacity and have very close performances to Shannon limit. In all communication systems, phase discontinuities of modulated signals result extra bandwidth requirements. Continuous phase modulation (CPM) is a powerful solution for this problem. Beside CPM provides good bandwidth efficiency; it also improves bit error performance with its memory unit. In our proposed scheme, LDPC and CPFSK, which is a special type of CPM, are considered together to improve both error performance and bandwidth efficiencies. We also obtain error performance curves of LDPCC‐CPFSK via computer simulations for both regular and irregular LDPC code. Simulation results are drawn for 4‐ary CPFSK, 8‐ary CPFSK and 16‐ary CPFSK over AWGN, Rician and Rayleigh fading channels for maximum 100 iterations, while the frame size is chosen as 504. Copyright © 2006 John Wiley & Sons, Ltd.
Method to Enhance Degraded Image in Dust Environment

Basically, the sharpness and contrast of the video images captured in dusty weather will be significantly degraded and diminished. This paper proposes a novel image enhancement method. First convert the degraded image into fuzzy domain to global PAL fuzzy enhancement; then band-limited histogram equalization is adopted for enhancing the local component in the spatial domain; finally POSHE algorithm is introduced to enhance the details. The experiment results show that this method not only can effectively improve the contrast of dust image, but also enhance the details of edge information and get a good visual effect of the image.
PR65A Phosphorylation Regulates PP2A Complex Signaling

Serine-threonine Protein phosphatase 2 A (PP2A), a member of the PPP family of phosphatases, regulates a variety of essential cellular processes, including cell-cycling, DNA replication, transcription, translation, and secondary signaling pathways. In the heart, increased PP2A activity/signaling has been linked to cardiac remodeling, contractile dysfunction and, in failure, arrythmogenicity. The core PP2A complex is a hetero-trimeric holoenzyme consisting of a 36 kDa catalytic subunit (PP2Ac); a regulatory scaffold subunit of 65 kDa (PR65A or PP2Aa); and one of at least 18 associated variable regulatory proteins (B subunits) classified into 3 families. In the present study, three in vivo sites of phosphorylation in cardiac PR65A are identified (S303, T268, S314). Using HEK cells transfected with recombinant forms of PR65A with phosphomimetic (P-PR65A) and non-phosphorylated (N-PR65A) amino acid substitutions at these sites, these phosphorylations were shown to inhibit the interaction of PR65A with PP2Ac and PP2A holoenzyme signaling. Forty-seven phospho-proteins were increased in abundance in HEK cells transfected with P-PR65A versus N-PR65A by phospho-protein profiling using 2D-DIGE analysis on phospho-enriched whole cell protein extracts. Among these proteins were elongation factor 1α (EF1A), elongation factor 2, heat shock protein 60 (HSP60), NADPH-dehydrogenase 1 alpha sub complex, annexin A, and PR65A. Compared to controls, failing hearts from the Dahl rat had less phosphorylated PR65A protein abundance and increased PP2A activity. Thus, PR65A phosphorylation is an in vivo mechanism for regulation of the PP2A signaling complex and increased PP2A activity in heart failure.
Ensino-Pesquisa-Extensão: notas para pensar a indissociabilidade

O texto pretende, de forma concisa, analisar as tentativas de juncao entre o ensino, a pesquisa e a extensao em instituicoes de superior. Propoe o entendimento dos conceitos de indissociabilidade, extensao, pesquisa e ensino, a partir de uma perspectiva critica, que rompe com a cultura dissociativa entre esses componentes curriculares. No sentido de contribuir com a superacao da indissociabilidade criticada,chega,ao final, a proposicao de diretrizes pedagogicas que resultam em uma dinâmica curricular para os cursos de graduacao. Conclui que a problematica da indissociabilidade e, antes de tudo, uma problematica da cultura pedagogica universitaria. Palavras-chave : Indissociabilidade; ensino; pesquisa; extensao; ensino superior.
Energy Management in Plug-in Hybrid Electric Vehicles: Recent Progress and a Connected Vehicles Perspective

Plug-in hybrid electric vehicles (PHEVs) offer an immediate solution for emissions reduction and fuel displacement within the current infrastructure. Targeting PHEV powertrain optimization, a plethora of energy management strategies (EMSs) have been proposed. Although these algorithms present various levels of complexity and accuracy, they find a limitation in terms of availability of future trip information, which generally prevents exploitation of the full PHEV potential in real-life cycles. This paper presents a comprehensive analysis of EMS evolution toward blended mode (BM) and optimal control, providing a thorough survey of the latest progress in optimization-based algorithms. This is performed in the context of connected vehicles and highlights certain contributions that intelligent transportation systems (ITSs), traffic information, and cloud computing can provide to enhance PHEV energy management. The study is culminated with an analysis of future trends in terms of optimization algorithm development, optimization criteria, PHEV integration in the smart grid, and vehicles as part of the fleet.
Dynamic hyperinflation during bronchoconstriction in asthma: implications for symptom perception.

OBJECTIVE The objective of this study was to examine the relationship between respiratory symptom intensity and quality and dynamic lung hyperinflation (DH) during induced bronchoconstriction in asthma. PATIENTS AND METHODS Subjects with asthma (n = 116) underwent baseline spirometry and lung volume measurement followed by high-dose methacholine challenge testing (MCT) [maximum decrease in FEV(1) of 50% from baseline]. Dyspnea intensity (Borg scale) was measured after each dose of methacholine. Qualitative descriptors of breathlessness and functional residual capacity (FRC) were measured at the doses nearest to the provocative concentration of methacholine causing a 20% fall in FEV (PC(20)) and at the highest dose of methacholine (maximum response). RESULTS FEV(1) decreased by 24.7 +/- 0.7% (mean +/- SEM) at the dose nearest to PC(20) and by 46.1 +/- 1.1% at maximum response. Inspiratory capacity decreased by 0.62 +/- 0.04 L at the dose nearest to PC(20) and 1.06 +/- 0.06 L at maximum response. The descriptor clusters "inspiratory difficulty," "chest tightness," "unsatisfied inspiration," and "work" were selected at the dose nearest to PC(20) but were more frequently selected at maximum response (p < 0.0001). Individuals who reported chest tightness at maximum response had greater airflow obstruction and higher FRC (percentage of predicted) than those who did not report chest tightness. CONCLUSIONS Four dominant qualities of dyspnea in asthma (inspiratory difficulty, chest tightness, unsatisfied inspiration, and work) were reported early in the course of MCT and evolved in parallel, becoming more prevalent at maximum response. Significant DH accompanied even mild bronchoconstriction during MCT in asthma, making it difficult to separate mechanisms of chest tightness from other dominant respiratory sensations.