Miracle-dz/UniFAR-FTUs huggingface dataset:
Adult‐acquired Flatfoot Deformity

Abstract Originally known as posterior tibial tendon dysfunction or insufficiency, adult‐acquired flatfoot deformity encompasses a wide range of deformities. These deformities vary in location, severity, and rate of progression. Establishing a diagnosis as early as possible is one of the most important factors in treatment. Prompt early, aggressive nonsurgical management is important. A patient in whom such treatment fails should strongly consider surgical correction to avoid worsening of the deformity. In all four stages of deformity, the goal of surgery is to achieve proper alignment and maintain as much flexibility as possible in the foot and ankle complex. However, controversy remains as to how to manage flexible deformities, especially those that are severe.
Behavioral methods for measuring effects of drugs on learning and memory in animals

This review describes methods for measuring effects of drugs on learning and memory in animals, proceeding from relatively simple nonassociative learning (habituation) to classical and instrumental conditioning, and concluding with complex measures for measuring learning and memory repeatedly in the individual animal. Procedures for separating drug effects specific to learning and memory from non-specific effects on activity, motivation, sensory and motor capacity, etc., were emphasized. For each method, selected experimental examples were presented which described the action of drugs on learning and memory, elucidated the behavioral processes involved in the drug effects, or illustrated methodological points. The various procedures used to measure drug effects on learning and memory in animals have yielded a bewildering array of often-contradictory results. Quantitative differences in effectiveness of drugs in the different procedures are common. Drugs (for example, the nootropics) that alter learning or memory in a few procedures may be totally without activity in many others. How are these discrepancies to be interpreted? The apparent inconsistencies in the data can, for the most part, be understood in terms of the nature of learning and memory. "Learning" and "memory" are hypothetical processes presumed to underlie enduring changes in behavior resulting from the organism's interaction with environmental stimuli. Given such a broad definition, the prevalence of inconsistencies in the data is hardly surprising. It is unlikely that the same mechanisms should underlie all of the wide variety of behavioral changes included under the rubrics "learning" or "memory. " (For a contrary view, based on consistencies among results obtained in the diverse procedures, see Zornetzer). How, then, should drug effects on learning and memory be identified or measured? The first step, of course, is to rule out those drug effects that do not conform to the definition of learning or memory. This review has described strategies and procedures by which this can be accomplished. However, even when this is done there is no single procedure that can detect drug effects on learning and memory in general, nor, in view of the heterogeneous behaviors involved, is it likely that such a universal procedure will ever be found. Thus, a multi-faceted strategy will be required. Some of the simpler procedures described in this review may be adequate for the initial identification of interesting effects. (ABSTRACT TRUNCATED AT 400 WORDS)
A Trellis Based Fast Lattice Generating Algorithm

Lattice is widely used as a kind of the search results in Large Vocabulary Continuous Speech Recognition (LVCSR). A new lattice-generation algorithm is presented in this paper. The algorithm is based on a classical forward-backward decoding method, which is proved to be highly efficient. Moreover, some improvements have been done to satisfy the requirements in the lattice decoding. Two Chinese mandarin large-scale speech recognition tasks are used to evaluate the proposed algorithm and the experimental results show that our algorithm can both improve decoding speed and save decoding space significantly without sacrificing the recognition accuracy, compared with the widely used Lattice decoding method as.
Fitting subdivision surfaces to unorganized point data using SDM

We study the reconstruction of smooth surfaces from point clouds. We use a new squared distance error term in optimization to fit a subdivision surface to a set of unorganized points, which defines a closed target surface of arbitrary topology. The resulting method is based on the framework of squared distance minimization (SDM) proposed by Pottmann et al. Specifically, with an initial subdivision surface having a coarse control mesh as input, we adjust the control points by optimizing an objective function through iterative minimization of a quadratic approximant of the squared distance function of the target shape. Our experiments show that the new method (SDM) converges much faster than the commonly used optimization method using the point distance error function, which is known to have only linear convergence. This observation is further supported by our recent result that SDM can be derived from the Newton method with necessary modifications to make the Hessian positive definite and the fact that the Newton method has quadratic convergence.
Quantitative Analysis of Cardiac Tissue Including Fibroblasts Using Three-Dimensional Confocal Microscopy and Image Reconstruction: Towards a Basis for Electrophysiological Modeling

Electrophysiological modeling of cardiac tissue is commonly based on functional and structural properties measured in experiments. Our knowledge of these properties is incomplete, in particular their remodeling in disease. Here, we introduce a methodology for quantitative tissue characterization based on fluorescent labeling, 3-D scanning confocal microscopy, image processing and reconstruction of tissue micro-structure at sub-micrometer resolution. We applied this methodology to normal rabbit ventricular tissue and tissue from hearts with myocardial infarction. Our analysis revealed that the volume fraction of fibroblasts increased from 4.83±0.42% (mean ± standard deviation) in normal tissue up to 6.51±0.38% in myocardium from infarcted hearts. The myocyte volume fraction decreased from 76.20±9.89% in normal to 73.48±8.02% adjacent to the infarct. Numerical field calculations on 3-D reconstructions of the extracellular space yielded an extracellular longitudinal conductivity of 0.264±0.082 S/m with an anisotropy ratio of 2.095±1.11 in normal tissue. Adjacent to the infarct, the longitudinal conductivity increased up to 0.400±0.051 S/m, but the anisotropy ratio decreased to 1.295±0.09. Our study indicates an increased density of gap junctions proximal to both fibroblasts and myocytes in infarcted versus normal tissue, supporting previous hypotheses of electrical coupling of fibroblasts and myocytes in infarcted hearts. We suggest that the presented methodology provides an important contribution to modeling normal and diseased tissue. Applications of the methodology include the clinical characterization of disease-associated remodeling.
Direct Evidence of the Anterior Cruciate Ligament-Hamstring Reflex Arc in Humans *

It has been emphasized that the anterior cruciate ligament plays an important role in the proprioceptive feedback system. The anterior cruciate ligament-hamstring reflex has been revealed in animal experiments, but it has not been established in humans. The purpose of this study was to demonstrate direct evidence of the anterior cruciate ligament-hamstring reflex arc. Nine knees in nine healthy subjects were investigated. The anterior cruciate ligament was stimulated by the use of wire electrodes inserted using an arthroscopic technique. Electromyographic signals from the biceps femoris and the semitendinosus muscles were recorded with surface electrodes. The change in electromyographic activity was analyzed after electrical stimulation in the normal knee condition, and again after intraarticular sensation had been interrupted with a local anesthetic. After electrical stimulation, subjects demonstrated increased electromyographic activity of the hamstring muscles in the normal knee condition. This response indicates the existence of an anterior cruciate ligament-hamstring reflex arc. Conversely, there was no change in activity for the hamstring muscle in the anesthetized knee because the afferent impulse from the neural elements of the anterior cruciate ligament had been removed.
Geology and Genesis of the Giant Pulang Porphyry Cu-Au District, Yunnan, Southwest China

This study was jointly funded by the National Key Research and Development Project of China (2016YFC0600305), the Major State Basic Research Program of the People’s Republic of China (2015CB452602), the National Natural Science Foundation of China (41825005, 41473041, 41273051), and the Ministry of Land and Resources of China (201011011)
Assessment of Response to Clinical Hypnosis: Development of the Hypnotic State Assessment Questionnaire

Abstract This study describes the development and preliminary psychometric properties of a scale for measuring hypnotic response in clinical hypnosis sessions. The Hypnotic State Assessment Questionnaire (HSAQ), a brief, multidimensional measure of hypnotic response during clinical sessions of hypnosis, is intended to facilitate supervision of hypnosis trainees and to document subjects' response in clinical hypnosis sessions. Results indicate that most HSAQ subscales have good interrater and internal consistency reliability. Furthermore, HSAQ observations correlated with post-hypnotic behaviors and subjective experiences of hypnosis. Use of the HSAQ in hypnosis training settings allows supervisors to obtain standardized data describing hypnosis sessions conducted by trainees. This data may also be used to document clinical response for record keeping or research.
Turbulence, representations, and trace‐preserving actions

We establish criteria for turbulence in certain spaces of C*‐algebra representations and apply this to the problem of nonclassifiability by countable structures for group actions on a standard atomless probability space (X, μ) and on the hyperfinite II1 factor R. We also prove that the conjugacy action on the space of free actions of a countably infinite amenable group on R is turbulent, and that the conjugacy action on the space of ergodic measure‐preserving flows on (X, μ) is generically turbulent.
An appraisal of ultramicrotomy, FIBSEM and cryogenic FIBSEM techniques for the sectioning of biological cells on titanium substrates for TEM investigation

Ultramicrotomy, focused ion beam scanning electron microscopy (FIBSEM) and cryogenic FIBSEM (cryo‐FIBSEM) techniques, as developed for the controlled cross‐sectioning of mesenchymal stem cells (MSCs) and human osteoblasts (HObs) on titanium (Ti) substrates for transmission electron microscopy (TEM) investigation, are compared. Conventional ultramicrotomy has been used to section cells on Ti‐foil substrates embedded in resin, but significant problems with cell detachment using this technique restricted its general applicability. Conventional FIBSEM ‘lift‐out’ procedures were found to be effective for the preparation of uniform sections of fixed and dehydrated cell/Ti specimens, but the control of cell staining remains an issue. Cryo‐FIBSEM procedures used with an ‘H‐bar’ sample geometry enabled the sectioning of fixed and hydrated cell/Ti specimens, but issues remain over ion beam‐induced artefacts and control of frost on the sample foils.
An optimal quantum algorithm for the oracle identification problem

In the oracle identification problem, we are given oracle access to an unknown N-bit string x promised to belong to a known set C of size M and our task is to identify x. We present a quantum algorithm for the problem that is optimal in its dependence on N and M. Our algorithm considerably simplifies and improves the previous best algorithm due to Ambainis et al. Our algorithm also has applications in quantum learning theory, where it improves the complexity of exact learning with membership queries, resolving a conjecture of Hunziker et al. The algorithm is based on ideas from classical learning theory and a new composition theorem for solutions of the filtered gamma_2-norm semidefinite program, which characterizes quantum query complexity. Our composition theorem is quite general and allows us to compose quantum algorithms with input-dependent query complexities without incurring a logarithmic overhead for error reduction. As an application of the composition theorem, we remove all log factors from the best known quantum algorithm for Boolean matrix multiplication.
Confocal Laser Endomicroscopy in Gastrointestinal and Pancreatobiliary Diseases: A Systematic Review and Meta-Analysis

Confocal laser endomicroscopy (CLE) is an endoscopic-assisted technique developed to obtain histopathological diagnoses of gastrointestinal and pancreatobiliary diseases in real time. The objective of this systematic review is to analyze the current literature on CLE and to evaluate the applicability and diagnostic yield of CLE in patients with gastrointestinal and pancreatobiliary diseases. A literature search was performed on MEDLINE, EMBASE, Scopus, and Cochrane Oral Health Group Specialized Register, using pertinent keywords without time limitations. Both prospective and retrospective clinical studies that evaluated the sensitivity, specificity, or accuracy of CLE were eligible for inclusion. Of 662 articles identified, 102 studies were included in the systematic review. The studies were conducted between 2004 and 2015 in 16 different countries. CLE demonstrated high sensitivity and specificity in the detection of dysplasia in Barrett's esophagus, gastric neoplasms and polyps, colorectal cancers in inflammatory bowel disease, malignant pancreatobiliary strictures, and pancreatic cysts. Although CLE has several promising applications, its use has been limited by its low availability, high cost, and need of specific operator training. Further clinical trials with a particular focus on cost-effectiveness and medicoeconomic analyses, as well as standardized institutional training, are advocated to implement CLE in routine clinical practice.
Survival and human papillomavirus in oropharynx cancer in TAX 324: a subset analysis from an international phase III trial.

BACKGROUND The association between human papillomavirus (HPV) and overall survival (OS) in oropharynx cancer (OPC) was retrospectively examined in TAX 324, a phase III trial of sequential therapy for locally advanced head and neck cancer. METHODS Accrual for TAX 324 was completed in 2003 and data updated through 2008. Pretherapy tumor biopsies were studied by PCR for human papillomavirus type 16 and linked to OS, progression-free survival (PFS) and demographics. RESULTS Of 264 patients with OPC, 111 (42%) had evaluable biopsies; 56 (50%) were HPV+ and 55 (50%) were HPV-. HPV+ patients were significantly younger (54 versus 58 years, P = 0.02), had T1/T2 primary cancers (49% versus 20%, P = 0.001), and had a performance status of zero (77% versus 49%, P = 0.003). OS and PFS were better for HPV+ patients (OS, hazard ratio = 0.20, P < 0.0001). Local-regional failure was less in HPV+ patients (13% versus 42%, P = 0.0006); at 5 years, 82% of HPV+ patients were alive compared with 35% of HPV- patients (P < 0.0001). CONCLUSIONS HPV+ OPC has a different biology compared with HPV- OPC; 5-year OS, PFS, and local-regional control are unprecedented. These results support the possibility of selectively reducing therapy and long-term morbidity in HPV+ OPC while preserving survival and approaching HPV- disease with more aggressive treatment.
Evidence for Stabilizing Selection on Codon Usage in Chromosomal Rearrangements of Drosophila pseudoobscura

There has been a renewed interest in investigating the role of stabilizing selection acting on genome-wide traits such as codon usage bias. Codon bias, when synonymous codons are used at unequal frequencies, occurs in a wide variety of taxa. Standard evolutionary models explain the maintenance of codon bias through a balance of genetic drift, mutation and weak purifying selection. The efficacy of selection is expected to be reduced in regions of suppressed recombination. Contrary to observations in Drosophila melanogaster, some recent studies have failed to detect a relationship between the recombination rate, intensity of selection acting at synonymous sites, and the magnitude of codon bias as predicted under these standard models. Here, we examined codon bias in 2798 protein coding loci on the third chromosome of D. pseudoobscura using whole-genome sequences of 47 individuals, representing five common third chromosome gene arrangements. Fine-scale recombination maps were constructed using more than 1 million segregating sites. As expected, recombination was demonstrated to be significantly suppressed between chromosome arrangements, allowing for a direct examination of the relationship between recombination, selection, and codon bias. As with other Drosophila species, we observe a strong mutational bias away from the most frequently used codons. We find the rate of synonymous and nonsynonymous polymorphism is variable between different amino acids. However, we do not observe a reduction in codon bias or the strength of selection in regions of suppressed recombination as expected. Instead, we find that the interaction between weak stabilizing selection and mutational bias likely plays a role in shaping the composition of synonymous codons across the third chromosome in D. pseudoobscura.
Neurogenesis and growth factors expression after complete spinal cord transection in Pleurodeles waltlii

Following spinal lesion, connections between the supra-spinal centers and spinal neuronal networks can be disturbed, which causes the deterioration or even the complete absence of sublesional locomotor activity. In mammals, possibilities of locomotion restoration are much reduced since descending tracts either have very poor regenerative ability or do not regenerate at all. However, in lower vertebrates, there is spontaneous locomotion recuperation after complete spinal cord transection at the mid-trunk level. This phenomenon depends on a translesional descending axon re-growth originating from the brainstem. On the other hand, cellular and molecular mechanisms underlying spinal cord regeneration and in parallel, locomotion restoration of the animal, are not well known. Fibroblast growth factor 2 (FGF-2) plays an important role in different processes such as neural induction, neuronal progenitor proliferation and their differentiation. Studies had shown an over expression of this growth factor after tail amputation. Nestin, a protein specific for intermediate filaments, is considered an early marker for neuronal precursors. It has been recently shown that its expression increases after tail transection in urodeles. Using this marker and western blots, our results show that the number of FGF-2 and FGFR2 mRNAs increases and is correlated with an increase in neurogenesis especially in the central canal lining cells immediately after lesion. This study also confirms that spinal cord re-growth through the lesion site initially follows a rostrocaudal direction. In addition to its role known in neuronal differentiation, FGF-2 could be implicated in the differentiation of ependymal cells into neuronal progenitors.
Inferring Reasons for the Failure of Staphylococcus aureus Vaccines in Clinical Trials

Multidrug resistant Staphylococcus aureus strains are emerging and current antibiotics are not efficacious against such strains. Therefore, there is an urgent need to develop vaccines to target this pathogen. However, both active and passive immunization strategies have thus far failed to show efficacy in humans. There are several potential reasons behind the disappointing results of clinical trials, however, we believe that just a few of them, which are common to all the trials, determined their downfall. First of all, preclinical results obtained with antigens tested in clinical trials were likely overestimated by vaccine manufacturers. Furthermore, vaccines tested in humans to date, since they all targeted single antigens, were probably disproportionate to the complex pathogenic mechanisms of the bacterium. In addition, the lack of known correlates of protection in humans has severely limited the ability to interpret both preclinical and clinical data. Finally, the vaccines did not contain new generation adjuvants, which may be critical in augmenting antibody production and steering the T-cell response toward the proper profile of cytokine production.
PunFields at SemEval-2017 Task 7: Employing Roget’s Thesaurus in Automatic Pun Recognition and Interpretation

The article describes a model of automatic interpretation of English puns, based on Roget’s Thesaurus, and its implementation, PunFields. In a pun, the algorithm discovers two groups of words that belong to two main semantic fields. The fields become a semantic vector based on which an SVM classifier learns to recognize puns. A rule-based model is then applied for recognition of intentionally ambiguous (target) words and their definitions. In SemEval Task 7 PunFields shows a considerably good result in pun classification, but requires improvement in searching for the target word and its definition.
Can't You Hear Me Knocking: Identification of User Actions on Android Apps via Traffic Analysis

While smartphone usage become more and more pervasive, people start also asking to which extent such devices can be maliciously exploited as "tracking devices". The concern is not only related to an adversary taking physical or remote control of the device, but also to what a passive adversary without the above capabilities can observe from the device communications. Work in this latter direction aimed, for example, at inferring the apps a user has installed on his device, or identifying the presence of a specific user within a network. In this paper, we move a step forward: we investigate to which extent it is feasible to identify the specific actions that a user is doing on mobile apps, by eavesdropping their encrypted network traffic. We design a system that achieves this goal by using advanced machine learning techniques. We did a complete implementation of this system and run a thorough set of experiments, which show that it can achieve accuracy and precision higher than 95% for most of the considered actions.
The effects of prior calcium channel blocker therapy on creatine kinase-MB levels after percutaneous coronary interventions

Background: Use of intracoronary calcium channel blockers (CCBs) during percutaneous coronary intervention (PCI) has been shown to have favorable effects on coronary blood flow. We aimed to investigate the effects of CCBs administrated perorally on creatine kinase-MB (CK-MB) levels in patients undergoing elective PCI. Methods: A total of 570 patients who underwent PCI were evaluated for CK-MB elevation. Patients who were on CCB therapy when admitted to the hospital constituted the CCB group. No CCBs were given to the rest of the patients during the periprocedural period and these patients served as the control group. Blood samples for CK-MB were obtained before and at 6 h, 24 h, and 36 h after the procedure. Results: 217 patients were in the CCB group (mean age 60.2 ± 9.3 years, 162 males), and 353 were in the control group (mean age 60.0 ± 10.1 years, 262 males). CK-MB levels increased above the normal values in 41 patients (18.9%) of the CCBs group and in 97 patients (27.5%) of the control group (p = 0.02). Median CK-MB levels were significantly higher in the control group for all studied hours (for all p < 0.05). Conclusions: Prior oral CCB therapy may have favorable effects in preventing myocyte necrosis after elective PCI.