Miracle-dz/UniFAR-FTUs huggingface dataset:
The flawed four‐level evaluation model

The lack of research to develop further a theory of evaluation is aglaring shortcoming for human resource development (HRD). In this paper, 1 argue that the four-level system of training evaluation is really a taxonomy of outcomes and is flawed as an evaluation model Research is needed to develop a fully specified and researchable evaluation model. Such a model needs to specify outcomes correctly, account for the effects of intervening variables that affect outcomes, and indicate causal relationships. I propose a new model based on existing research and accounts for the impact of the primary intervening variables such as motivation to learn, trainability, job attitudes, personal characteristics, and transfer of training conditions. A new role for participant reactions is specified. Key studies supporting the model are reviewed and a research agenda proposed.
The role of nutricline depth in regulating the ocean carbon cycle

Carbon uptake by marine phytoplankton, and its export as organic matter to the ocean interior (i.e., the “biological pump”), lowers the partial pressure of carbon dioxide (pCO2) in the upper ocean and facilitates the diffusive drawdown of atmospheric CO2. Conversely, precipitation of calcium carbonate by marine planktonic calcifiers such as coccolithophorids increases pCO2 and promotes its outgassing (i.e., the “alkalinity pump”). Over the past ≈100 million years, these two carbon fluxes have been modulated by the relative abundance of diatoms and coccolithophores, resulting in biological feedback on atmospheric CO2 and Earth's climate; yet, the processes determining the relative distribution of these two phytoplankton taxa remain poorly understood. We analyzed phytoplankton community composition in the Atlantic Ocean and show that the distribution of diatoms and coccolithophorids is correlated with the nutricline depth, a proxy of nutrient supply to the upper mixed layer of the ocean. Using this analysis in conjunction with a coupled atmosphere–ocean intermediate complexity model, we predict a dramatic reduction in the nutrient supply to the euphotic layer in the coming century as a result of increased thermal stratification. Our findings indicate that, by altering phytoplankton community composition, this causal relationship may lead to a decreased efficiency of the biological pump in sequestering atmospheric CO2, implying a positive feedback in the climate system. These results provide a mechanistic basis for understanding the connection between upper ocean dynamics, the calcium carbonate-to-organic C production ratio and atmospheric pCO2 variations on time scales ranging from seasonal cycles to geological transitions.
On Sampling Colorings of Bipartite Graphs

We study the problem of efficiently sampling k-colorings of bipartite graphs. We show that a class of markov chains cannot be used as efficient samplers. Precisely, we show that, for any k, 6 ≤ k ≤ n^\1/3-e \, e > 0 fixed, \emphalmost every bipartite graph on n+n vertices is such that the mixing time of any markov chain asymptotically uniform on its k-colorings is exponential in n/k^2 (if it is allowed to only change the colors of O(n/k) vertices in a single transition step). This kind of exponential time mixing is called \emphtorpid mixing. As a corollary, we show that there are (for every n) bipartite graphs on 2n vertices with Δ (G) = Ω (\ln n) such that for every k, 6 ≤ k ≤ Δ /(6 \ln Δ ), each member of a large class of chains mixes torpidly. While, for fixed k, such negative results are implied by the work of CDF, our results are more general in that they allow k to grow with n. We also show that these negative results hold true for H-colorings of bipartite graphs provided H contains a spanning complete bipartite subgraph. We also present explicit examples of colorings (k-colorings or H-colorings) which admit 1-cautious chains that are ergodic and are shown to have exponential mixing time. While, for fixed k or fixed H, such negative results are implied by the work of CDF, our results are more general in that they allow k or H to vary with n.
CLASS MOBILITY IN THE INDUSTRIAL WORLD

The main interest of this review is in the developments in social mobility research during the last ten years. These can be characterized as the revitalization of the class perspective, intensive comparative (cross-national and cross-temporal) research efforts, and the large-scale application of the log-linear modeling approach. After discussing the basic ideas of mobility studies conducted in an explicit class framework and the developments regarding class concepts, the review summarizes the major results of empirical research as to intergenerational mobility of men and women. These results are yielded within different conceptual frameworks for several industrialized countries. It continues by examining the constituent worklife processes, stressing the effects of different institutional arrangements and of labor market conditions for intragenerational mobility. Finally, a brief summary of the research desiderata still existing in social mobility research closes the review.
Crystal Structure of the RNA Polymerase Domain of the West Nile Virus Non-structural Protein 5*

Viruses of the family Flaviviridae are important human and animal pathogens. Among them, the Flaviviruses dengue (DENV) and West Nile (WNV) cause regular outbreaks with fatal outcomes. The RNA-dependent RNA polymerase (RdRp) activity of the non-structural protein 5 (NS5) is a key activity for viral RNA replication. In this study, crystal structures of enzymatically active and inactive WNV RdRp domains were determined at 3.0- and 2.35-Å resolution, respectively. The determined structures were shown to be mostly similar to the RdRps of the Flaviviridae members hepatitis C and bovine viral diarrhea virus, although with unique elements characteristic for the WNV RdRp. Using a reverse genetic system, residues involved in putative interactions between the RNA-cap methyltransferase (MTase) and the RdRp domain of Flavivirus NS5 were identified. This allowed us to propose a model for the structure of the full-length WNV NS5 by in silico docking of the WNV MTase domain (modeled from our previously determined structure of the DENV MTase domain) onto the RdRp domain. The Flavivirus RdRp domain structure determined here should facilitate both the design of anti-Flavivirus drugs and structure-function studies of the Flavivirus replication complex in which the multifunctional NS5 protein plays a central role.
An assessment of community suicide risk.

The contributions of several core variables to the white suicide rates in 24 Florida counties were examined, and a prediction equation, using multiple linear regression, was developed. Age was found to be about 50% more important than divorce. With both age and divorce controlled, loneliness and insanity were found to be significant core variables (p less than .05). A prediction equation including age, crime rate, insanity, and alcoholism was found that accounted for 79% of the variation in the suicide rates across counties. The observed rates were divided by predicted rates to yield standardized mortality ratios. It is proposed that these ratios may serve to assess both the need for and the impact of community suicide prevention services by placing suicide rates in the context of relevant social conditions.
Modelling Perception Updating of Travel Times in the Context of Departure Time Choice Under ITS

Traffic information is increasingly regarded as a tool to achieve a more efficient use of the road network. As traffic information is often applied in the context of routine trips, the question arises how travellers integrate traffic information with the knowledge of travel conditions gained through daily experience. To describe this process, the paper proposes a model of perception updating of travel times in the context of departure time decisions. The model applies a CHAID-based classification algorithm to describe how travellers classify trips made under various conditions (departure time and presence of traffic information) into mental classes with comparable expectations in terms of travel time. Thus, it is assumed that the learning process depends on a set of conditions, one of which is the available travel time information. The model is tested through a series of numerical experiments. The results suggest that the model describes learning and adaptation behaviour in a plausible way. Through increased experience, perception of travel times is improved, and more departure time classes are distinguished. However, this does not seem to lead to shorter travel times or higher trip utilities. Also the presence of travel time information may be, depending on the history of trip outcomes, distinguished as a significant indicator of the expected travel time. We conclude that the model provides a good starting point for the further development of learning and adaptation models in the context of ITS.
Participation, consultation, confusion: professionals' understandings of children's participation in physical planning

This article discusses how professionals understand the theory and practice of children's participation in physical planning processes. Drawing on group discussions between Swedish professionals we analyse how children's participation is understood and negotiated, and why it is problematic to implement. The participants had difficulties in understanding the difference between participation and consultation, as well as recognising children as social actors with competences. We argue that while Swedish children have a strong position in society, they are excluded from planning processes due to the rigidity of the planning process, neoliberal influences and planners' lack of competence.
Investigation of the values found in primary education science and technology textbooks in Turkey

In this study, the value types of 6, 7 and 8 class text books which take place in the primary education science and technology education program, have been targeted for investigation for the present rate of these values ​​in different textbooks, and, whether they changed in accordance with class variables (class, subject content, and divisions of the unit). For this purpose, science and technology activities in textbooks, texts, and different values for each grade level were analyzed ​​"Values Form in the ​​Textbooks (DKDF)" and the data obtained were analyzed using the SPSS program 17.00 quantitatively. At the end of the study, it has been found that mostly the theoretical values​​ had been used in the science and technology textbooks and the value types had shown variations according to the class, subject content and the unit sections. Key words: Values, elementary science education, textbook.
[Comparative analysis of narcosis and local anesthesia in surgery of malignant melanoma of the skin].

A nonrandomized trial was performed to compare the survival rate attained in patients with malignant melanoma who underwent their operations under general anaesthesia (g.a.) and in those who underwent surgery with only local anaesthesia (l.a.). All stage I patients were treated and followed up in our hospital exclusively. Data recorded in 190 patients operated on under g.a. from 1972 to 1980 and 376 patients operated on with l.a. from 1981 to 1987 were evaluated by computer. The 5-year survival rates calculated by the Kaplan-Meier method were as follows: Breslow's thickness up to 1.50 mm (pT1 and pT2): g.a. 91.4% l.a. 94.5%; 1.51-3.00 mm (pT3a) g.a. 64.1%, l.a. 84.5% (P less than 0.01); over 3.00 mm (pT3b and pT4) g.a. 57.9%, l.a. 62.2% (P greater than 0.05). Women with pT3a melanoma had more benefit from the operation in l.a. (93.1% to 69.7%) than did men (71.6% to 55.2%). The l.a. does not prejudice the prognosis, whether the l.a. improves the prognosis has to be stated. The available evidence that anaesthetic agents influence host defence could be an explanation for the better results with l.a.
Comparison of Trihalomethanes in Tap Water and Blood

A M Y M . M I L E S , † P H I L I P C . S I N G E R , * , † D A V I D L . A S H L E Y , † M I C H E L E C . L Y N B E R G , ‡ P A U L I N E M E N D O L A , § P E T E R H . L A N G L O I S , | A N D J . R . N U C K O L S ⊥ Department of Environmental Sciences and Engineering, University of North Carolina, CB 7400, Chapel Hill, North Carolina 27599-7400, Centers for Disease Control and Prevention, Atlanta, Georgia, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, Texas Birth Defects Monitoring Division, Texas Department of Health, Austin, TX, and Department of Environmental Health, Colorado State University, Ft. Collins, Colorado
Fault localization for data-centric programs

In this paper we present an automated technique for localizing faults in data-centric programs. Data-centric programs primarily interact with databases to get collections of content, process each entry in the collection(s), and output another collection or write it back to the database. One or more entries in the output may be faulty. In our approach, we gather the execution trace of a faulty program. We use a novel, precise slicing algorithm to break the trace into multiple slices, such that each slice maps to an entry in the output collection. We then compute the semantic difference between the slices that correspond to correct entries and those that correspond to incorrect ones. The "diff" helps to identify potentially faulty statements. We have implemented our approach for ABAP programs. ABAP is the language used to write custom code in SAP systems. It interacts heavily with databases using embedded SQL-like commands that work on collections of data. On a suite of 13 faulty ABAP programs, our technique was able to identify the precise fault location in 12 cases.
Specific effect of interferon on the herpes simplex virus type 1 transactivation event

Human recombinant gamma interferon and to a lesser extent alpha interferon were shown to inhibit herpes simplex virus type 1 replication in the human cell lines WISH and HEp-2. Dot blot analysis of viral DNA synthesis and viral RNA transcription indicated that the inhibition occurred at an early step in infection. A study of the early events after herpes simplex virus type 1 infection indicated that adsorption, penetration, uncoating, and transport of viral DNA were not affected by interferon. Northern (RNA) blot analysis revealed that both immediate-early and delayed-early gene transcription was inhibited by interferon. Transactivation of the immediate-early responsive element linked to a reporter gene (CAT or tk) was specifically inhibited by both classes of interferon. Our data would indicate that either the transactivating protein VP16 or the complex formed between VP16 and a host protein(s) is attenuated by interferon.
Stimulus-Locked and Response-Locked ERP Correlates of Spatial Inhibition of Return (IOR) in Old Age

Behavioral research has shown that Inhibition of Return (IOR) is preserved in old age although at longer time intervals between cue and target, which has been interpreted as reflecting a later disengagement from the cue. A recent event-related potential (ERP) study attributed this age-related pattern to an enhanced processing of the cue. Previous ERP research in young samples indicates that target and response processing are also affected by IOR, which makes interesting to study the ERP correlates of IOR from cue presentation to response execution. In this regard, in the present study stimulus-locked (cue-locked and target-locked) and response-locked ERPs were explored in healthy young and older participants. The behavioral results indicated preserved IOR in the older participants. The cue-locked ERPs could suggest that the older participants processed the cue as a warning signal to prepare for the upcoming target stimulus. Under IOR, target-locked ERPs of both age groups showed lower N1 amplitudes sugges.
Knowledge, Attitudes, and Informational Behaviors of College Students in Regard to the Human Papillomavirus

Abstract Objective: To assess students’ human papillomavirus (HPV) knowledge, attitudes, and behaviors. Participants/ Methods: Students (N = 1,282) at a large, public university in the Northeast United States completed a questionnaire during February 2008 assessing HPV knowledge, prevalence, transmission, cervical cancer risk and stigma; sexual behavior, vaccination status, as well as past and preferred sources of information about HPV and sexual health. Results: A majority of respondents know of HPV. However, understanding was insufficient in several important areas. Overwhelmingly, respondents heard about HPV via television commercials yet preferred to obtain sexual health information from physicians. Hearing about HPV on a TV commercial was associated with increased knowledge. More knowledge of HPV was associated with less stigma. Men exhibit a higher level of stigma and less knowledge than women. Conclusions: Publicly funded health campaigns aimed at increasing knowledge about HPV are overdue and necessary. This is especially true for efforts targeting young adults about this extremely common sexually transmitted infection (STI).
A Multiple-Group Confirmatory Factor Analysis of Self-Determination Between Groups of Adolescents With Intellectual Disability or Learning Disabilities

Promoting self-determination has been identified as an important practice for the successful transition of youth and young adults with disabilities, and numerous studies have examined the relationship between levels of self-determination and transition-related and postsecondary outcomes. Only a few such studies, however, have examined the global self-determination of students with disabilities. The majority of those studies measured self-determination using The Arc’s Self-Determination Scale (SDS) and involved students with intellectual disability (ID) or learning disabilities (LD), examining the impact of interventions, environment, disability category, intelligence level, and gender on self-determination. Although students with intellectual and LD are often studied as a single group, for students with cognitive disabilities, there have been no studies that examine whether assessments are measuring the same construct within these two populations. The purpose of this study is to test for measurement invariance to examine further whether a measure like the SDS is assessing the same concept in students with ID and in students with LD by conducting analysis with a series of multiple-group confirmatory factor analysis (CFA). Results showed that the SDS is measuring the same construct across both groups; however, significant differences in both groups were found in latent variances/covariances and latent means.
Robot soccer vision: An overview for new learner

Vision is a part of a robot soccer system. It completes the system by providing the ‘eye’ to see what occurs inside the pitch during the game. Similarly as in humans, the sight is then sent to the ‘brain’. The control system needs to be processed before making any decision to be sent back to robots on the field to react. The process will be repeated over and over again. This paper discusses the robot soccer vision system which deals with surface theory and some examples of applications used. Suggestions for future improvement are included at the end of this paper.
CARMA1 Controls an Early Checkpoint in the Thymic Development of FoxP3+ Regulatory T Cells1

Natural regulatory T cells (nTregs) that develop in the thymus are essential to limit immune responses and prevent autoimmunity. However, the steps necessary for their thymic development are incompletely understood. The CARMA1/Bcl10/Malt1 (CBM) complex, comprised of adaptors that link the TCR to the transcription factor NF-κB, is required for development of regulatory T cells (Tregs) but not conventional T cells. Current models propose that TCR-NF-κB is needed in a Treg-extrinsic manner for IL-2 production by conventional T cells or in already precommitted Treg precursors for driving IL-2/STAT5 responsiveness and further maturation into Tregs and/or for promoting cell survival. Using CARMA1-knockout mice, our data show instead that the CBM complex is needed in a Treg-intrinsic rather than -extrinsic manner. Constitutive activity of STAT5 or protection from apoptosis by transgenic expression of Bcl2 in developing Tregs is not sufficient to rescue CARMA1-knockout Treg development. Instead, our results demonstrate that the CBM complex controls an early checkpoint in Treg development by enabling generation of thymic precursors of Tregs. These data suggest a modified model of nTreg development in which TCR-CBM-dependent signals are essential to commit immature thymocytes to the nTreg lineage.
The syndapin protein family: linking membrane trafficking with the cytoskeleton

Syndapins – also called PACSINs – are highly conserved Src-homology 3 (SH3)-domain-containing proteins that seem to exist in all multicellular eukaryotes. They interact with the large GTPase dynamin and several other proteins implicated in vesicle trafficking. Syndapin-dynamin complexes appear to play an important role in vesicle fission at different donor membranes, including the plasma membrane (endocytosis) and Golgi membranes. In addition, syndapins are implicated in later steps of vesicle cycling in neuronal and non-neuronal cells. Syndapins also interact with N-WASP, a potent activator of the Arp2/3 complex that forms a critical part of the actin polymerization machinery. Syndapin oligomers can thereby couple bursts of actin polymerization with the vesicle fission step involving dynamins. This allows newly formed vesicles to move away from the donor membrane driven by actin polymerization. Syndapins also engage in additional interactions with molecules involved in several signal transduction pathways, producing crosstalk at the interface between membrane trafficking and the cytoskeleton. Given the distinct expression patterns of the different syndapins and their splice forms, these proteins could have isoform-specific functions.
Lower limb activity and its determinants in COPD

Background: Patients with chronic obstructive pulmonary disease (COPD) walk less than healthy older people and their self-reported activity predicts exacerbation risk. The relationship between lower limb activity and total daily activity is not known, nor are there any data which relate objectively assessed daily activity to laboratory assessments made before and after rehabilitation. Methods: Lower limb activity was measured by leg actigraphy over 3 days in 45 patients with moderate to severe COPD and 18 controls of similar age. Thirty-three patients with COPD entered an 8-week rehabilitation programme in which the change in leg activity was measured and related to other outcomes. Results: In patients with COPD the mean level of activity measured by whole body and leg activity monitors was closely related (r = 0.92; p<0.001), but leg activity was consistently reduced compared with controls of similar age (p = 0.001). Mean leg activity, mean intensity of leg activity and the time that patients spent mobile at home were all related to forced expiratory volume in 1 s (FEV1) (r = 0.57, p = 0.001; r = 0.5, p = 0.003; and r = 0.51, p = 0.002, respectively), but intensity of activity and time spent mobile were not related. Subjects completing pulmonary rehabilitation showed significant improvements in mean activity (p = 0.001) and spent more time moving (p = 0.014). These changes were unrelated to improvement in muscle strength or walking distance but correlated with baseline FEV1 (r = 0.8, p<0.001). Conclusions: Total daily activity in patients with COPD is closely related to leg activity which is reduced compared with controls of similar age. Individuals differ in the time spent mobile during the day, but subjective and objectively assessed activity improves after rehabilitation and is predicted by FEV1. The change in activity is unrelated to improvements in corridor walking and health status.