Miracle-dz/UniFAR-FTUs huggingface dataset:
Ethnic composition of the school class and interethnic attitudes: a multi-group perspective

ABSTRACT This study investigates the relationship between the ethnic classroom composition and interethnic attitudes of adolescents of the native majority and several ethnic minorities in the Netherlands, Germany, England and Sweden. It contributes to prior research by examining the underlying theoretical features of contact opportunities and levels of threat across multiple ethnic groups more accurately, using group-specific measures. Based on Intergroup Contact Theory and Ethnic Group Conflict Theory, contrasting hypotheses on how the ethnic classroom composition affects out-group and in-group attitudes of adolescents are tested with multilevel regression analyses. Across ethnic groups and countries, we consistently find a moderate to substantial relation between ethnic classroom composition and interethnic attitudes in line with Intergroup Contact Theory: a relatively larger out-group size, compared to the in-group, relates positively to out-group attitudes. At the same time, in several cases, a relatively larger in-group size relates to more positive in-group attitudes. The findings point to the significance of balanced ethnic classroom compositions for promoting favourable attitudes between multiple ethnic groups – benefitting especially those who face high levels of prejudice from others and those who are prejudiced towards others – without compromising positive in-group attitudes.
Impaired integration of disambiguating evidence in delusional schizophrenia patients

Background It has been previously demonstrated that a cognitive bias against disconfirmatory evidence (BADE) is associated with delusions. However, small samples of delusional patients, reliance on difference scores and choice of comparison groups may have hampered the reliability of these results. In the present study we aimed to improve on this methodology with a recent version of the BADE task, and compare larger groups of schizophrenia patients with/without delusions to obsessive–compulsive disorder (OCD) patients, a population with persistent and possibly bizarre beliefs without psychosis. Method A component analysis was used to identify cognitive operations underlying the BADE task, and how they differ across four groups of participants: (1) high-delusional schizophrenia, (2) low-delusional schizophrenia, (3) OCD patients and (4) non-psychiatric controls. Results As in past studies, two components emerged and were labelled ‘evidence integration’ (the degree to which disambiguating information has been integrated) and ‘conservatism’ (reduced willingness to provide high plausibility ratings when justified), and only evidence integration differed between severely delusional patients and the other groups, reflecting delusional subjects giving higher ratings for disconfirmed interpretations and lower ratings for confirmed interpretations. Conclusions These data support the finding that a reduced willingness to adjust beliefs when confronted with disconfirming evidence may be a cognitive underpinning of delusions specifically, rather than obsessive beliefs or other aspects of psychosis such as hallucinations, and illustrates a cognitive process that may underlie maintenance of delusions in the face of counter-evidence. This supports the possibility of the BADE operation being a useful target in cognitive-based therapies for delusions.
SNP Association Mapping across the Extended Major Histocompatibility Complex and Risk of B-Cell Precursor Acute Lymphoblastic Leukemia in Children

The extended major histocompatibility complex (xMHC) is the most gene-dense region of the genome and harbors a disproportionately large number of genes involved in immune function. The postulated role of infection in the causation of childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) suggests that the xMHC may make an important contribution to the risk of this disease. We conducted association mapping across an approximately 4 megabase region of the xMHC using a validated panel of single nucleotide polymorphisms (SNPs) in childhood BCP-ALL cases (n=567) enrolled in the Northern California Childhood Leukemia Study (NCCLS) compared with population controls (n=892). Logistic regression analyses of 1,145 SNPs, adjusted for age, sex, and Hispanic ethnicity indicated potential associations between several SNPs and childhood BCP-ALL. After accounting for multiple comparisons, one of these included a statistically significant increased risk associated with rs9296068 (OR=1.40, 95% CI=1.19-1.66, corrected p=0.036), located in proximity to HLA-DOA. Sliding window haplotype analysis identified an additional locus located in the extended class I region in proximity to TRIM27 tagged by a haplotype comprising rs1237485, rs3118361, and rs2032502 (corrected global p=0.046). Our findings suggest that susceptibility to childhood BCP-ALL is influenced by genetic variation within the xMHC and indicate at least two important regions for future evaluation.
Lung epithelial tip progenitors integrate glucocorticoid- and STAT3-mediated signals to control progeny fate

Insufficient alveolar gas exchange capacity is a major contributor to lung disease. During lung development, a population of distal epithelial progenitors first produce bronchiolar-fated and subsequently alveolar-fated progeny. The mechanisms controlling this bronchiolar-to-alveolar developmental transition remain largely unknown. We developed a novel grafting assay to test if lung epithelial progenitors are intrinsically programmed or if alveolar cell identity is determined by environmental factors. These experiments revealed that embryonic lung epithelial identity is extrinsically determined. We show that both glucocorticoid and STAT3 signalling can control the timing of alveolar initiation, but that neither pathway is absolutely required for alveolar fate specification; rather, glucocorticoid receptor and STAT3 work in parallel to promote alveolar differentiation. Thus, developmental acquisition of lung alveolar fate is a robust process controlled by at least two independent extrinsic signalling inputs. Further elucidation of these pathways might provide therapeutic opportunities for restoring alveolar capacity. Highlighted Article: Glucocorticoid receptor and STAT3 signalling act in parallel, but cross-regulated, pathways to control epithelial differentiation during lung alveolar development in mice.
Association Study to Evaluate FoxO1 and FoxO3 Gene in CHD in Han Chinese

Background Coronary heart disease (CHD) is one of the leading causes of mortality and morbidity in China. Genetic factors that predispose individuals to CHD are unclear. In the present study, we aimed to determine whether the variation of FoxOs, a novel genetic factor associated with longevity, was associated with CHD in Han Chinese populations. Methods 1271 CHD patients and 1287 age-and sex-matched controls from Beijing and Harbin were included. We selected four tagging single nucleotide polymorphisms (SNPs) of FoxO1 (rs2755209, rs2721072, rs4325427 and rs17592371) and two tagging SNPs of FoxO3 (rs768023 and rs1268165). And the genotypes of these SNPs were determined in both CHD patients and non-CHD controls. Results For population from Beijing, four SNPs of FoxO1 and two SNPs of FoxO3 were found not to be associated with CHD (p>0.05). And this was validated in the other population from Harbin (p>0.05). After combining the two geographically isolated case-control populations, the results showed that the six SNPs did not necessarily predispose to CHD in Han Chinese(p>0.05). In stratified analysis according to gender, the history of smoking, hypertension, diabetes mellitus, hyperlipidemia and the metabolic syndrome, we further explored that neither the variants of FoxO1 nor the variants of FoxO3 might be associated with CHD (p>0.05). Conclusion The variants of FoxO1 and FoxO3 may not increase the prevalence of CHD in Han Chinese population.
A Novel Dynamic System in the Space of SPD Matrices with Applications to Appearance Tracking

In this paper, we address the problem of video tracking using covariance descriptors constructed from simple features extracted from the given image sequence. Theoretically, this can be posed as a tracking problem in the space of ($n \times n$) symmetric positive definite (SPD) matrices denoted by $P_n$. A novel probabilistic dynamic model in $P_n$ based on Riemannian geometry and probability theory is presented in conjunction with a geometric (intrinsic) recursive filter for tracking a time sequence of SPD matrix measurements in a Bayesian framework. This newly developed filtering method can be used for the covariance descriptor updating problem in covariance tracking, leading to new and efficient video tracking algorithms. To show the accuracy and efficiency of our tracker in comparison to the state-of-the-art, we present synthetic experiments on $P_n$ and several real data experiments for tracking in video sequences.
Distinctive Left Ventricular Activations Associated With ECG Pattern in Heart Failure Patients

Background— In contrast to patients with left bundle branch block (LBBB), heart failure patients with narrow QRS and nonspecific intraventricular conduction delay (NICD) display a relatively limited response to cardiac resynchronization therapy. We sought to compare left ventricular (LV) activation patterns in heart failure patients with narrow QRS and NICD to patients with LBBB using high-density electroanatomic activation maps. Methods and Results— Fifty-two heart failure patients (narrow QRS [n=18], LBBB [n=11], NICD [n=23]) underwent 3-dimensional electroanatomic mapping with a high density of mapping points (387±349 LV). Adjunctive scar imaging was available in 37 (71%) patients and was analyzed in relation to activation maps. LBBB patients typically demonstrated (1) a single LV breakthrough at the septum (38±15 ms post-QRS onset); (2) prolonged right-to-left transseptal activation with absence of direct LV Purkinje activity; (3) homogeneous propagation within the LV cavity; and (4) latest activation at the basal lateral LV. In comparison, both NICD and narrow QRS patients demonstrated (1) multiple LV breakthroughs along the posterior or anterior fascicles: narrow QRS versus LBBB, 5±2 versus 1±1; P=0.0004; NICD versus LBBB, 4±2 versus 1±1; P=0.001); (2) evidence of early/pre-QRS LV electrograms with Purkinje potentials; (3) rapid propagation in narrow QRS patients and more heterogeneous propagation in NICD patients; and (4) presence of limited areas of late activation associated with LV scar with high interindividual heterogeneity. Conclusions— In contrast to LBBB patients, narrow QRS and NICD patients are characterized by distinct mechanisms of LV activation, which may predict poor response to cardiac resynchronization therapy.
Convolutional Network Cleaned labels Legend Predicted labelsImage Classifier concatenate low dimensional embeddings Label Cleaning Network

We present an approach to effectively use millions of images with noisy annotations in conjunction with a small subset of cleanly-annotated images to learn powerful image representations. One common approach to combine clean and noisy data is to first pre-train a network using the large noisy dataset and then fine-tune with the clean dataset. We show this approach does not fully leverage the information contained in the clean set. Thus, we demonstrate how to use the clean annotations to reduce the noise in the large dataset before fine-tuning the network using both the clean set and the full set with reduced noise. The approach comprises a multi-task network that jointly learns to clean noisy annotations and to accurately classify images. We evaluate our approach on the recently released Open Images dataset, containing∼9 million images, multiple annotations per image and over 6000 unique classes. For the small clean set of annotations we use a quarter of the validation set with ∼40k images. Our results demonstrate that the proposed approach clearly outperforms direct fine-tuning across all major categories of classes in the Open Image dataset. Further, our approach is particularly effective for a large number of classes with wide range of noise in annotations (2080% false positive annotations).
What, if anything, are hybrids: enduring truths and challenges associated with population structure and gene flow

Hybridization is a potent evolutionary process that can affect the origin, maintenance, and loss of biodiversity. Because of its ecological and evolutionary consequences, an understanding of hybridization is important for basic and applied sciences, including conservation biology and agriculture. Herein, we review and discuss ideas that are relevant to the recognition of hybrids and hybridization. We supplement this discussion with simulations. The ideas we present have a long history, particularly in botany, and clarifying them should have practical consequences for managing hybridization and gene flow in plants. One of our primary goals is to illustrate what we can and cannot infer about hybrids and hybridization from molecular data; in other words, we ask when genetic analyses commonly used to study hybridization might mislead us about the history or nature of gene flow and selection. We focus on patterns of variation when hybridization is recent and populations are polymorphic, which are particularly informative for applied issues, such as contemporary hybridization following recent ecological change. We show that hybridization is not a singular process, but instead a collection of related processes with variable outcomes and consequences. Thus, it will often be inappropriate to generalize about the threats or benefits of hybridization from individual studies, and at minimum, it will be important to avoid categorical thinking about what hybridization and hybrids are. We recommend potential sampling and analytical approaches that should help us confront these complexities of hybridization.
A perceptually-weighted deep neural network for monaural speech enhancement in various background noise conditions

Deep neural networks (DNN) have recently been shown to give state-of-the-art performance in monaural speech enhancement. However in the DNN training process, the perceptual difference between different components of the DNN output is not fully exploited, where equal importance is often assumed. To address this limitation, we have proposed a new perceptually-weighted objective function within a feedforward DNN framework, aiming to minimize the perceptual difference between the enhanced speech and the target speech. A perceptual weight is integrated into the proposed objective function, and has been tested on two types of output features: spectra and ideal ratio masks. Objective evaluations for both speech quality and speech intelligibility have been performed. Integration of our perceptual weight shows consistent improvement on several noise levels and a variety of different noise types.
Cognitively challenging physical activity benefits executive function in overweight children

Abstract This study tested the association between aerobic fitness and executive function and the impact of enhanced, cognitively challenging physical activity on executive function in overweight and lean children. Seventy children aged 9–10 years were assigned to either a 6-month enhanced physical education programme including cognitively demanding (open skill) activities or curricular physical education only. Pre- and post-intervention tests assessed aerobic capacity (Leger test) and two components of executive function: inhibition and working memory updating (random number generation task). Indices of inhibition and memory updating were compared in higher- and lower-fit children and intervention effects were evaluated as a function of physical activity programme (enhanced vs. curricular) and weight status (lean vs. overweight). Results showed better inhibition in higher- than lower-fit children, extending the existing evidence of the association between aerobic fitness and executive function to new aspects of children’s inhibitory ability. Overweight children had more pronounced pre- to post-intervention improvements in inhibition than lean children only if involved in enhanced physical education. Such intervention effects were not mediated by aerobic fitness gains. Therefore, the cognitive and social interaction challenges inherent in open skill tasks, even though embedded in a low-dose physical activity programme, may represent an effective means to promote cognitive efficiency, especially in overweight children.
Serum Transaminase Levels in Experimental Myocardial Infarction

Serum glutamic oxalacetic transaminase concentrations rise sharply after myocardial infarction produced by bead embolization of the coronary tree in the closed chest dog. The peak concentration is reached in 9 to 23 hours post injury. Rises 20 to 30 times greater than normal may be obtained and are directly correlated with the amount of infarction estimated at autopsy. Serial serum transaminase levels may provide a clinical tool to supplement the electrocardiogram in the diagnosis of acute myocardial infarction as well as provide a roughly quantitative estimate of the amount of myocardium involved.
Eccentric Exercise in Chronic Tendinitis

Chronic tendinitis, particularly of the Achilles tendon, frequently outwits traditional programs of therapy including surgery and/or prolonged immobilization. A hypothesis proposes that disruption of the tendon, micro or macro, occurs under specific conditions of eccentric loading. In order for the healing tendon to be adequately rehabilitated, the treatment program must include specific eccentric strength rebuilding exercises.
Examining the relationship between communities' 'age-friendliness' and life satisfaction and self-perceived health in rural Manitoba, Canada.

INTRODUCTION Population aging is a worldwide phenomenon. As a response, the World Health Organization (WHO) introduced the concept of 'age-friendliness' in 2006. Age-friendliness is defined in terms of a range of domains, such as housing, opportunities for participation, and transportation. Communities that accommodate the needs of older adults in these domains will, it is thought, promote healthy, active aging. The purpose of the present study was to examine communities' age-friendliness and its relationship to health-related outcomes in a rural context. METHODS The study included 29 communities located in Manitoba, a mid-Western Canadian province, that are part of the Province of Manitoba's Age-Friendly Manitoba Initiative. As part of a needs assessment process in these communities, 593 individuals, including seniors and younger adults, completed an Age-Friendly Survey. The survey was designed to measure a variety of features in seven domains (the physical environment, housing options, the social environment, opportunities for participation, community supports and healthcare services, transportation options, and communication and information), as well as containing measures of life satisfaction and self-perceived health. Community characteristics were derived from census data. Moreover, communities were categorized on a rural-urban continuum. RESULTS Multi-level regressions indicated that an overall Age-Friendly Index was positively related to both life satisfaction (b=0.019, p<0.0001) and self-perceived health (b=0.013, p<0.01). When examining more specifically each of the seven age-friendly domains, all but housing was positively related to life satisfaction. Results were not as consistent for self-perceived health, with significant relationships emerging only for the physical environment, social environment, opportunities for participation, and transportation options. A subsequent analysis for seniors versus younger participants, respectively, indicated that significant relationships between age-friendly domains and life satisfaction and self-perceived health were restricted primarily to seniors. None of the community characteristics were related to life satisfaction and self-perceived health, nor was degree of rurality. CONCLUSIONS The concept of age-friendliness has been garnering considerable attention from policy-makers as a way to promote healthy aging. For example, in Canada, several provinces have launched age-friendly initiatives. Although causality cannot be inferred from the present, cross-sectional study, the findings are encouraging as they show that age-friendliness is associated with enhanced life satisfaction and self-perceived health in a rural context. The study further supports the notion that a wide range of domains within the community environment are important in older adults' lives and need to be considered. Public policy initiatives, such as the Province of Manitoba's Age-Friendly Initiative, may thus be one approach to enhancing healthy aging in rural settings.
Flexible and Stretchable Energy Storage: Recent Advances and Future Perspectives

Energy‐storage technologies such as lithium‐ion batteries and supercapacitors have become fundamental building blocks in modern society. Recently, the emerging direction toward the ever‐growing market of flexible and wearable electronics has nourished progress in building multifunctional energy‐storage systems that can be bent, folded, crumpled, and stretched while maintaining their electrochemical functions under deformation. Here, recent progress and well‐developed strategies in research designed to accomplish flexible and stretchable lithium‐ion batteries and supercapacitors are reviewed. The challenges of developing novel materials and configurations with tailored features, and in designing simple and large‐scaled manufacturing methods that can be widely utilized are considered. Furthermore, the perspectives and opportunities for this emerging field of materials science and engineering are also discussed.
GST gene variants in synchronous colorectal cancers and synchronous association of colorectal cancers with other cancers.

BACKGROUND the present study evaluates genetic polymorphisms of three glutathione S-transferases (GSTM1, GSTT1and GSTP1) in patients with synchronous malignant colorectal tumors and the association of synchronous colorectal cancers with other cancers. MATERIAL AND METHODS from 420 patients with a colorectal cancer admitted to our hospital between 2005-2012, we selected for genetic analysis 20 patients with multiple synchronous malignant colorectal tumors and 9 patients with asynchronous association of colorectal cancer with another cancer. We searched for GST genotypes, comparing the results with controls. RESULTS the genetic analysis was possible only in 19 patients with colorectal synchronous cancers and 9 patients with asynchronous association of colorectal cancer with another cancer; we found a statistically significant difference for null GSTM1 genotype frequency between these patients and the control group; we found no differences regarding the frequency of null GSTT1 genotype and Ile105Val polymorphism of GSTP1 in patients with synchronous cancers compared with the control group. CONCLUSION in our study we found the null GSTM1 genotype as a risk factor for multiple colorectal synchronous cancers and for an association of synchronous colorectal with other cancers