Miracle-dz/UniFAR-FTUs huggingface dataset:
Diagnostic boundaries between regulatory and multisystem developmental disorders: A clinical study

L'objectif de cette etude etait de definir des limites de diagnostic entre les Troubles de la Regulation (Regulatory Disorders, en anglais, ici abrege RD) et les Troubles Multi-systeme du Comportement (en anglais, Multisystem Developmental Disorders, ici abrege MSDD). Deux groupes de 15 sujets, âges de 20 a 30 mois, diagnostiques avec RD ou MSDD, selon le critere DC: 0-3 (1994), ont ete compares sur les profils relationnels, linguistiques et comportementaux en utilisant des instruments specifiques. Les resultats ont montre que les enfants RD et MSDD etaient affectes sur toutes les mesures linguistiques avec un degre d'affectation MSDD plus eleve pour les gestes de communication, la parole spontanee et la comprehension verbale. La Checklist de Comportement de l'Enfant d'Achenbach (Child Behavior Checklist, en anglais) a fait etat de differences importantes pour les problemes isoles et somatiques. Seul le groupe MSDD a atteint le score clinique limite dans les problemes globaux, les comportements d'internalisation et d'isolations. Une analyse de discrimination a montre que le nombre de gestes communicatifs et les scores sur les problemes isoles et somatiques predisait correctement 86% des cas. La conclusion est que les enfants RD et MSDD font preuves de differents quantitatives et qualitatives sur bien des dimensions linguistiques, comportementales et relationnelles qui ont ete explorees. Ces dimensions peuvent faciliter le diagnostic differentiel de ces troubles.
A Simple Channel Model for Investigation of Multiuser Scheduling in MIMO Broadcast Channels

In this paper, a simple multiple input multiple output (MIMO) broadcast channel model is proposed and compared with measured MIMO channels. The proposed model uses a sum-of-sinusoids model for temporal correlation and the Kronecker model for spatial correlation. MIMO channel measurements were performed in the city of Bristol, UK as a part of the Mobile VCE programme. These were conducted in the 2 GHz frequency band with two pairs of dual polarized transmit antennas (4 transmit antennas) at the base station and with two pairs of crossed dipoles (4 receive antennas) at the receiver for different locations in a dense urban cellular environment. For validation of the proposed MIMO model, the standard deviation of cross correlations and eigenvalues are compared between the measured data and the simulated data. Numerical results demonstrate that the temporal correlation is more meaningful than the spatial correlation in view of multiuser scheduling in MIMO broadcast channels. Indeed, the proposed model has similar characteristics to the measured MIMO channels taking into account temporal correlation properties.
Regulation of contraction-induced FA uptake and oxidation by AMPK and ERK1/2 is intensity dependent in rodent muscle.

Muscle contraction activates AMP-activated protein kinase (AMPK) and extracellular signal-regulated kinase (ERK1/2), two signaling molecules involved in the regulation of muscle metabolism. The purpose of this study was to determine whether activation of AMPK and/or ERK1/2 contributes to the regulation of muscle fatty acid (FA) uptake and oxidation in contracting muscle. Rat hindquarters were perfused during rest (R) or electrical stimulation (E) of increasing intensity by manipulating train duration (E1 = 25 ms, E2 = 50 ms, E3 = 100 ms, E4 = 200 ms). For matched FA delivery, FA uptake was significantly greater than R during E1, E2, and E3 (7.8 +/- 0.7 vs. 14.4 +/- 0.3, 16.9 +/- 0.8, 15.2 +/- 0.5 nmol.min(-1). g(-1), respectively, P < 0.05), but not during E4 (8.3 +/- 0.3 nmol.min(-1). g(-1), P > 0.05). FA oxidation was significantly greater than R during E1 and E2 (1.5 +/- 0.1 vs. 2.3 +/- 0.2, 2.5 +/- 0.2 nmol.min(-1). g(-1), P < 0.05) before returning to resting levels for E3 and E4 (1.8 +/- 0.1 and 1.5 +/- 0.2 nmol.min(-1). g(-1), P > 0.05). A positive correlation was found between FA uptake and ERK1/2 phosphorylation from R to E3 (R(2) = 0.55, P < 0.05) and between FA oxidation and ERK1/2 phosphorylation from R to E2 (R(2) = 0.76, P < 0.05), correlations that were not maintained when the data for E4 and E3 and E4, respectively, were included in the analysis (R(2) = 0.04 and R(2) = 0.03, P > 0.05). A positive correlation was also found between FA uptake and FA oxidation and AMPK activity for all exercise intensities (R(2) = 0.57, R(2) = 0.65 respectively, P < 0.05). These results, in combination with previous data from our laboratory, suggest that ERK1/2 and AMPK are the predominant signaling molecules regulating FA uptake and oxidation during low- to moderate-intensity muscle contraction and during moderate- to high-intensity muscle contraction, respectively.
Are we afraid of our selves? Self-narrative research in leisure studies

Abstract During the past decade, leisure scholars have started becoming more comfortable with applying to their work newer approaches to knowledge and research methodologies, many of which are being utilized in other social sciences. Self-narrative research, or autoethnography, is a form of inquiry that raises questions regarding separations and interactions of personal and professional identities. While personal narrative research has been in use since the 1980s, we argue that it remains unfamiliar and/or personally and professionally threatening to many leisure scholars. This article builds from leisure scholars' recent discussions on the influence of poststructuralism, narrative inquiry, and the need for reflexive methodologies within leisure research. We extend this discussion one step further, highlighting the need for self-narrative research in leisure. We then outline the ensuing benefits and ethical ramifications of such research, which we believe is capable of making unique contributions to leisure studies.
Rfc5, a replication factor C component, is required for regulation of Rad53 protein kinase in the yeast checkpoint pathway

The RFC5 gene encodes a small subunit of replication factor C (RFC) complex in Saccharomyces cerevisiae. We have previously shown that a temperature-sensitive (ts) rfc5-1 mutation is impaired in the S-phase checkpoint. In this report, we show that the rfc5-1 mutation is sensitive to DNA-damaging agents. RFC5 is necessary for slowing the S-phase progression in response to DNA damage. The phosphorylation of the essential central transducer, Rad53 protein kinase, is reduced in response to DNA damage in rfc5-1 mutants during the S phase. Furthermore, the inducibility of RNR3 transcription in response to DNA damage is dependent on RFC5. It has been shown that phosphorylation of Rad53 is controlled by Mec1 and Tel1, members of the subfamily of ataxia-telangiectasia mutated (ATM) kinases. We also demonstrate that overexpression of TEL1 suppresses the ts growth defect and DNA damage sensitivity of rfc5-1 mutants and restores phosphorylation of Rad53 and RNR3 induction in response to DNA damage in rfc5-1. Our results, together with the observation that overexpression of RAD53 suppresses the defects of the rfc5-1 mutation, suggest that Rfc5 is part of a mechanism transducing the DNA damage signal to the activation of the central transducer Rad53.
Effectiveness of community outreach and engagement in recruitment success for a prebirth cohort

Introduction We describe the effectiveness of community outreach and engagement in supporting recruitment for the US National Children’s Vanguard Study between 2009 and 2012. Methods Thirty-seven study locations used 1 of 4 strategies to recruit 18–49-year-old pregnant or trying to conceive women: (1) Initial Vanguard Study used household-based recruitment; (2) Direct Outreach emphasized self-referral; (3) Enhanced Household-Based Recruitment enhanced Initial Vanguard Study strategies; and (4) Provider-Based Recruitment recruited through healthcare providers. Outreach and engagement included advance letters, interactions with healthcare providers, participation in community events, contacts with community organizations, and media outreach. Results After 1–2 years, 41%–74% of 9844 study-eligible women had heard about the National Children’s Vanguard Study when first approached. Women who heard were 1.5–3 times more likely to consent. Hearing via word-of-mouth or the media most frequently predicted consent. The more sources women heard from the higher the odds of consent. Conclusions We conclude that tailored outreach and engagement facilitate recruitment in cohort studies.
Beginning Special Educators: Problems of Practice and the Influence of School Context

The purpose of this paper is to discuss the results of a study we conducted with our former special education student teachers during their first and second years of teaching. We investigated these beginning special educators' problems of practice and the influence of the school context on teachers' abilities to solve their problems. The results indicated that novice special educators were troubled by issues related to instruction and curriculum, understanding the system, mainstreaming and inclusion, and exhaustion. The results also indicated that these teachers received little support from their general education colleagues or administrators; most of their support came from other special educators. Implications for teacher education are discussed.
We Are the Tea Party!: The Use of Facebook as an Online Political Forum for the Construction and Maintenance of in-Group Identification during the “GOTV” Weekend

Researchers have found Facebook to be a viable tool for major party candidates; however, few scholars have sought to investigate how Facebook messages influence an emerging political group's online identity. This study examined how Tea Party supporters used Facebook to construct and maintain an identity during the “Get Out The Vote” weekend. Applying a grounded theory approach, we found that Tea Party supporters engaged in two types of polarization language strategies to construct and preserve their online identity. The implications of these findings are discussed in terms of the “echo chamber” effect.
Executive information system failure: a New Zealand case study

It is well known that executive information systems (EIS) are high risk systems to implement and maintain. Factor research is the most commonly used framework for studying the causes of EIS failure yet there is no conclusive evidence that the factors suggested in the information systems (IS) research literature ensure system success. This paper reports on a case study of a failed EIS in a large New Zealand organization and compares this case with the success factors found in the research literature. One of the findings is that the broader issues surrounding the failure were more significant than the more narrowly focused factors suggested by the factor research approach. These broader issues include the social, cultural, political and economic context of the system as a whole. Another finding was that many of these broader contextual issues were not directly controllable by the EIS project team. This paper will have implications for all those who have to develop or are involved with the development of EIS.
The engineering of concurrent simulations of complex systems

Concurrent process-oriented programming is a natural medium for simulating complex systems, particularly systems where many simple components interact in an environment (which may itself be complex). There is little guidance for engineering complex systems simulation. In the context of simulation work to support immunological research, we explore relevant approaches to modelling, and draw on concepts from dependable and high-integrity systems engineering, including the emphasis on the need to validate all aspects of the simulation.
Clustering and visualization of multivariate time series

The exploratory investigation of multivariate time series (MTS) may become extremely difficult, if not impossible, for high dimensional datasets. Paradoxically, to date, little research has been conducted on the exploration of MTS trough unsupervised clustering and visualization. In this chapter, the authors describe generative topographic mapping through time (GTM-TT), a model with foundations in probability theory that performs such tasks. The standard version of this model has several limitations that limit its applicablility. Here, the authors reformulate it within a Bayesian approach using variational techniques. The resulting variational Bayesian GTM-TT, described in some details, is shown to behave very robustly in the presence of noise in the MTS, helping to avert the poblem of data overfitting.
Statistical Machine Translation of Texts with Misspelled Words

This paper investigates the impact of misspelled words in statistical machine translation and proposes an extension of the translation engine for handling misspellings. The enhanced system decodes a word-based confusion network representing spelling variations of the input text. We present extensive experimental results on two translation tasks of increasing complexity which show how misspellings of different types do affect performance of a statistical machine translation decoder and to what extent our enhanced system is able to recover from such errors.
The role of the Atlantic corridor project as a form of strategic community of practice in facilitating business transformations in Latin America

Purpose – This paper aims to summarise the scope, methodology and main findings of a doctoral thesis about business transformation in Latin America taken from a project management (PM) and communities of practice (CoP) perspective.Design/methodology/approach – The project adopted a case study approach in which the candidate was a consultant, embedded as a member of the business transformation entity. Data were gathered using public and private documentation, unstructured interview data, and observation and were validated through review of evidence with participants.Findings – The concept of the strategic CoP is supported as a useful means to help facilitate trust and commitment as well as knowledge sharing and how this facilitated greater understanding trust and commitment building mechanisms through effective leadership. The trigger to allow willingness of former rivals to cooperate through this entity is acknowledged as being a set of external pressures in the Latin American region coupled with deregula.
Moving from Textual Relations to Ontologized Relations

There has been recent research in open-ended information extraction from text that finds relational triples of the form (arg1, relation phrase, arg2), where the relation phrase is a text string that expresses a relation between two arbitrary noun phrases. While such a relational triple is a good first step, much further work is required to turn such a textual relation into a logical form that supports inferencing. The strings from arg1 and arg2 must be normalized, disambiguated, and mapped to a formal taxonomy. The relation phrase must likewise be normalized and mapped to a clearly defined logical relation. Some relation phrases can be mapped to a set of pre-defined relations such as Part-0f and Causes. We focus instead on arbitrary relation phrases that are discovered from text. For this, we need to automatically merge synonymous relations and discover meta-properties such as entailment. Ultimately, we want the coverage of a bottom-up approach together with the rich set of axioms associated with a
Can social network sites enable political action

Social network sites (SNS) like MySpace and Facebook have re-organised the web, but to what ends? Fantasies about political action dance in the air while activists dream that this structure will allow people to speak truth to power. Yet, these daydreams are shattered through even a cursory look at what practices are actually taking place. Typical SNS users are more invested in adding glitter to pages and SuperPoking their ‘friends’ than engaging in any form of civically driven collective action. How did this happen? Technology’s majestical lustre makes it easy to fool people into believing that technology’s structure determines practice. It seems like such a simple conclusion – video games will make us violent, the Internet will make us more informed, and social network sites will make us politically activated, right? Wrong. Unfortunately, this techno-determinist doctrine does not actually hold up to interrogation. As science and technology scholars have argued, technology can best be understood through its social construction. Technologies are shaped by society and reflect society’s values back at us, albeit a bit refracted. If we accept that technologies mirror and magnify everyday culture, what do social network sites say about society? While we may wish that they shine a positive light, the most insidious practices on SNS highlight how status-obsessed and narcissistic we as a society are. We may wish to blame the technology for creating self-absorbed people, but it is probably more likely that egoists love social network sites because these services support their desire to exhibit oneself for the purposes of mass validation. By demonising the technology, we fail to fully grok the not-so-subtle message that society values beauty, exhibitionism, and self-aggrandisement and that social network sites provide opportunities for anyone to showcase themselves as pseudo-celebrities. Although these performances may not be ‘real’ because anyone can self-construct to put their best foot forward, they are certainly less scripted than reality TV. It may not be possible to get as much mindshare as Britney Spears, but social network sites certainly provide a platform for attention-seeking populations to do their thing. While such a critique surely evokes profiles of women revealing skin in provocative poses, the most active egoists on social network sites are musicians, politicians, marketers, and other populations who desperately want the attention of the masses. By and large, when politicians and activists
Genotypes and phenotypes in children with short stature: clinical indicators of SHOX haploinsufficiency

Background: Short stature affects approximately 2% of children, representing one of the more frequent disorders for which clinical attention is sought during childhood. Despite assumed genetic heterogeneity, mutations or deletions of the short stature homeobox-containing gene (SHOX) are found quite frequently in subjects with short stature. Haploinsufficiency of the SHOX gene causes short stature with highly variable clinical severity, ranging from isolated short stature without dysmorphic features to Léri-Weill syndrome, and with no functional copy of the SHOX gene, Langer syndrome. Methods: To characterise the clinical and molecular spectrum of SHOX deficiency in childhood we assessed the association between genotype and phenotype in a large cohort of children of short stature from 14 countries. Results: Screening of 1608 unrelated individuals with sporadic or familial short stature revealed SHOX mutations or deletions in 68 individuals (4.2%): complete deletions in 48 (70.6%), partial deletions in 4 (5.9%) and point mutations in 16 individuals (23.5%). Although mean height standard deviation score (SDS) was not different between participants of short stature with or without identified SHOX gene defects (–2.6 vs –2.6), detailed examination revealed that certain bone deformities and dysmorphic signs, such as short forearm and lower leg, cubitus valgus, Madelung deformity, high-arched palate and muscular hypertrophy, differed markedly between participants with or without SHOX gene defects (p<0.001). Phenotypic data were also compared for 33 children with Turner syndrome in whom haploinsufficiency of SHOX is thought to be responsible for the height deficit. Conclusion: A phenotype scoring system was developed that could assist in identifying the most appropriate subjects for SHOX testing. This study offers a detailed genotype-phenotype analysis in a large cohort of children of short stature, and provides quantitative clinical guidelines for testing of the SHOX gene.
Research on BA scale-free random graph models

Systems as diverse as genetic networks or the World Wide Web are best described as networks with complex topology. A common property of many large networks is that the vertex connectivities follow a scale-free power-law distribution. This feature was found to be a consequence of three generic mechanisms: (i) networks expand continuously by the addition of new vertices, (ii) new vertex with different number edges of randomly selected that connected to different vertices in the system, and (iii) new vertices attach preferentially to sites that are already well connected. A model based on these three ingredients reproduces the observed stationary scale-free distributions, which indicates that the development of large networks is governed by robust self-organizing phenomena that go beyond the particulars of the individual systems.
Phospholipase Cδ1 induces E-cadherin expression and suppresses malignancy in colorectal cancer cells

Significance We found that expression of phospholipase Cδ1 (PLCδ1) is down-regulated in colorectal cancer (CRC) cells compared with normal colon epithelium. Ectopic expression of PLCδ1 in CRC cells induced expression of E-cadherin, a tumor-suppressive cell–cell adhesion molecule, whereas knockdown of PLCδ1 repressed E-cadherin expression. Moreover, PLCδ1 overexpression reduced the malignant phenotypes of CRC. We also identified that PLCδ1 expression is repressed by the Kirsten rat sarcoma viral oncogene homolog (KRAS)/mitogen-activated protein kinase kinase (MEK) pathway, which is constitutively activated in many of CRC cells. Furthermore, PLCδ1 expression suppressed the phosphorylation of ERK1/2, which is an MEK target, by E-cadherin induction. These data suggest that PLCδ1 has tumor-suppressive functions in CRC through E-cadherin induction and KRAS/MEK/ERK signal attenuation. These findings could provide a valuable strategy for CRC treatment. Colorectal cancer (CRC) is one of the most common causes of cancer-related deaths worldwide, and Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations in CRC predict the ineffectiveness of EGF receptor-targeted therapy. Previous transcriptional microarray analysis suggests the association between phospholipase Cδ1 (PLCδ1) expression and KRAS mutation status in CRC. However, both the roles and the regulatory mechanisms of PLCδ1 in CRC are not known. Here, we found that the expression of PLCδ1, one of the most basal PLCs, is down-regulated in CRC specimens compared with normal colon epithelium by immunohistochemistry. Furthermore, we examined the roles of PLCδ1 in CRC cell lines that harbor an activating KRAS mutation. Ectopic expression of PLCδ1 in CRC cells induced the expression of E-cadherin, whereas knockdown of PLCδ1 repressed the expression of E-cadherin. Moreover, the overexpression of PLCδ1 suppressed the expression of several mesenchymal genes and reduced cell motility, invasiveness, and in vivo tumorigenicity of SW620 CRC cells. We also showed that PLCδ1 expression is repressed by the KRAS/mitogen-activated protein kinase kinase (MEK) pathway. Furthermore, PLCδ1 suppressed the phosphorylation of extracellular signal-regulated kinase (ERK)1/2 through E-cadherin induction in CRC cells, suggesting the presence of a negative regulatory loop between KRAS/MEK/ERK signaling and PLCδ1. These data indicate that PLCδ1 has tumor-suppressive functions in CRC through E-cadherin induction and KRAS/MEK/ERK signal attenuation.