Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of 30 per cent maternal nutrient restriction from 0.16 to 0.5 gestation on fetal baboon kidney gene expression

Previous studies in rodents and sheep show that maternal nutrient restriction during pregnancy alters fetal renal development. To date, no studies using fetal baboon RNA with human Affymetrix gene chips have been published. In the present study we have (1) evaluated the specificity of the Affymetrix human gene array ‘Laboratory on a Chip’ system for use with fetal baboon mRNA and (2) investigated the effects of moderate maternal global nutrient restriction (NR; 70% of ad libitum animals) from early (30 days gestation (dG)) to mid‐gestation (90 dG; term = 184 dG) on the fetal baboon kidney. Morphometric and blood measurements were made on 12 non‐pregnant baboons before they were bred. All baboons were fed ad libitum until 30 days pregnant, at which time six control baboons continued to feed ad libitum (control – C) while six received 70% of the C diet on a weight adjusted basis. Fetal kidneys were collected following caesarean section at 90 dG, with samples flash frozen and fixed for histological assessment. Fetal hip circumference was decreased in the NR group (68 ± 2 versus 75 ± 2 mm), while fetal body weight and all other measurements of fetal size were not different between C and NR at 90 dG. Maternal body weight was decreased in the NR group (12.16 ± 0.34 versus 13.73 ± 0.55 kg). Having established the specificity of the Affymetrix system for fetal baboon mRNA, gene expression profiling of fetal kidneys in the context of our maternal nutrient restriction protocol shows that NR resulted in a down‐regulation of genes in pathways related to RNA, DNA and protein biosynthesis, metabolism and catabolism. In contrast, genes in cell signal transduction, communication and transport pathways were up‐regulated in the NR group. These changes indicate that even a moderate level of maternal global NR impacts fetal renal gene pathways. Our histological assessment of renal structure indicates decreased tubule density within the cortex of NR kidneys compared with controls. The number of glomerular cross‐sections per unit area were unaffected by NR, suggesting that tubule tortuosity and/or tubule length was decreased in the NR kidney. Taken together the changes indicate that NR results in accelerated fetal renal differentiation. The negative impact of poor maternal nutrition on the fetal kidney may therefore be in part due to shortening of critical phases of renal growth resulting in decreased functional capacity in later life. These findings may have important implications for postnatal renal function, thereby contributing to the observed increased predisposition to hypertension and renal disease in the offspring of nutrient restricted mothers.
ArtistRank: an Analysis for the Brazilian Phonographic Scenario

The phonographic scenario has changed the way of measuring the artist's popularity. The measurement of an artist's popularity by selling discs or plays on radios was replaced by the artist's dissemination in digital media. Magazines such as Billboard and Rolling Stone build artists rankings, and we may observe that, despite producing many different results, they are accepted in the phonographic scenario. However, they do not have a totally open methodology. In this context, this work aims to apply a methodology for the construction of rankings of artists considering data coming from digital media and TV in the national phonographic scenario. We concluded that the methodology presents satisfactory results and important insights, consistent with the reality of the Brazilian phonographic scenario.
Short-term impact of cancer prevention and screening activities on quality of life.

PURPOSE There are few data on the short-term effects of participating in cancer prevention activities, undergoing genetic risk assessment, or having routine screening. The objective of this article is to systematically review existing research on short-term effects of prevention, genetic counseling and testing, and screening activities on quality of life. METHODS We conducted a MEDLINE search for original research studies that were published between January 1, 1985, and December 31, 2002, and conducted in North America or Western Europe. Data were abstracted and summarized using a standardized format. RESULTS We reviewed 210 publications. Most studies focused on psychological states (anxiety, depression), symptoms, or general health status. One hundred thirty-one studies used 51 previously validated noncancer instruments. Many researchers (12.6%) also added cancer-specific measures, such as perceived cancer risk or symptom indices. Only one study measured satisfaction or quality of provider-client communication. While one report examined lost workdays, no other economic consequences of short-term outcomes were evaluated. Among seven studies that assessed short-term outcomes preferences, only four specifically used time trade-off or linear rating scale methods. No study used standard gamble or willingness-to-pay methods. The overwhelming majority of research indicated that short-term effects were transient. Only two studies linked short-term effects to long-term cancer-related health behaviors such as repeat screening. CONCLUSION There is considerable heterogeneity in short-term outcome measurement. Clinicians need to be aware of potential for short-term, transient adverse effects. The impact of short-term experiences should to be linked to long-term health status and use of services.
A Generic Model for Assessing Multilevel Security-Critical Object-Oriented Programs

The most promising approach for developing secure systems is the one which allows software developers to assess and compare the relative security of their programs based on their designs. Thereby, software metrics provide an easy approach for evaluating the security of certain object-oriented designs. They can also measure the impact on security that caused by modifications to existing programs. However, most studies in this area focus on a binary classification of data, either is classified or unclassified. In fact, there are other models with other classifications of data, for instance, the common model used by Defense departments that classifies data into four security levels. However, these various classifications have received little attention in terms of measuring their effect. This paper introduces a model for measuring information flow of security-critical data within a certain object-oriented program with multilevel classification of its security-critical data. It defines a set of object-oriented security metrics which are capable of assessing the security of a given program’s design from the point of view of potential information flow. These metrics can be used to compare the security of programs or assess the effect of program modifications on security. Specifically, this paper proposes a generic model that consists of several security metrics to measure the relative security of object-oriented designs with respect to design quality properties of accessibility, cohesion, coupling, and design size.
A Broad Profile of Co-Dominant Epitopes Shapes the Peripheral Mycobacterium tuberculosis Specific CD8+ T-Cell Immune Response in South African Patients with Active Tuberculosis

We studied major histocompatibility complex (MHC) class I peptide-presentation and nature of the antigen-specific CD8+ T-cell response from South African tuberculosis (TB) patients with active TB. 361 MHC class I binding epitopes were identified from three immunogenic TB proteins (ESAT-6 [Rv3875], Ag85B [Rv1886c], and TB10.4 [Rv0288], including amino acid variations for Rv0288, i.e., A10T, G13D, S27N, and A71S for MHC allotypes common in a South African population (e.g., human leukocyte antigen [HLA]-A*30, B*58, and C*07). Inter-allelic differences were identified regarding the broadness of the peptide-binding capacity. Mapping of frequencies of Mycobacterium tuberculosis (M. tb) antigen-specific CD8+ T-cells using 48 different multimers, including the newly constructed recombinant MHC class I alleles HLA-B*58:01 and C*0701, revealed a low frequency of CD8+ T-cell responses directed against a broad panel of co-dominant M. tb epitopes in the peripheral circulation of most patients. The antigen-specific responses were dominated by CD8+ T-cells with a precursor-like phenotype (CD45RA+CCR7+). The data show that the CD8+ T-cell response from patients with pulmonary TB (prior to treatment) is directed against subdominant epitopes derived from secreted and non-secreted M. tb antigens and that variant, natural occurring M. tb Rv0288 ligands, have a profound impact on T-cell recognition.
Self-stabilising Overlay Network for Efficient Processes Numbering in Large Scale Systems

We introduce a self-stabilising algorithm that builds an overlay network in any large scale system, such as a peer to peer system. This allows several applications, such as efficient routing and consecutive processes numbering. We assume that every process can communicate with any other process provided it knows its identifier, which is usually the case in e.g. a peer to peer system, and that nodes may arrive or leave at any time. The algorithm uses a neighbourless model for the sake of scalability and relies on the composition of several subalgorithms.
Spatial organization of astrocytes in ferret visual cortex

Astrocytes form an intricate partnership with neural circuits to influence numerous cellular and synaptic processes. One prominent organizational feature of astrocytes is the “tiling” of the brain with non‐overlapping territories. There are some documented species and brain region–specific astrocyte specializations, but the extent of astrocyte diversity and circuit specificity are still unknown. We quantitatively defined the rules that govern the spatial arrangement of astrocyte somata and territory overlap in ferret visual cortex using a combination of in vivo two‐photon imaging, morphological reconstruction, immunostaining, and model simulations. We found that ferret astrocytes share, on average, half of their territory with other astrocytes. However, a specific class of astrocytes, abundant in thalamo‐recipient cortical layers (“kissing” astrocytes), overlap markedly less. Together, these results demonstrate novel features of astrocyte organization indicating that different classes of astrocytes are arranged in a circuit‐specific manner and that tiling does not apply universally across brain regions and species. J. Comp. Neurol. 524:3561–3576, 2016. © 2016 The Authors The Journal of Comparative Neurology Published by Wiley Periodicals, Inc.
Toward Cloud-Based Key Management for Outsourced Databases

A major drawback of implementing Database-as-a-Service (DaaS) on untrusted servers is the complexity of key management required for handling revocation. In this paper we put forward the idea of using the cloud for decoupling the management of local, user-specific encryption keys from the one of role-specific protection keys, obtaining simple key management and revocation schemes.
Genome-Wide Linkage Mapping of QTL for Yield Components, Plant Height and Yield-Related Physiological Traits in the Chinese Wheat Cross Zhou 8425B/Chinese Spring

Identification of genes for yield components, plant height (PH), and yield-related physiological traits and tightly linked molecular markers is of great importance in marker-assisted selection (MAS) in wheat breeding. In the present study, 246 F8 RILs derived from the cross of Zhou 8425B/Chinese Spring were genotyped using the high-density Illumina iSelect 90K single nucleotide polymorphism (SNP) assay. Field trials were conducted at Zhengzhou and Zhoukou of Henan Province, during the 2012–2013 and 2013–2014 cropping season under irrigated conditions, providing data for four environments. Analysis of variance (ANOVA) of agronomic and physiological traits revealed significant differences (P < 0.01) among RILs, environments, and RILs × environments interactions. Broad-sense heritabilities of all traits including thousand kernel weight (TKW), PH, spike length (SL), kernel number per spike (KNS), spike number/m2 (SN), normalized difference in vegetation index at anthesis (NDVI-A) and at 10 days post-anthesis (NDVI-10), SPAD value of chlorophyll content at anthesis (Chl-A) and at 10 days post-anthesis (Chl-10) ranged between 0.65 and 0.94. A linkage map spanning 3609.4 cM was constructed using 5636 polymorphic SNP markers, with an average chromosome length of 171.9 cM and marker density of 0.64 cM/marker. A total of 866 SNP markers were newly mapped to the hexaploid wheat linkage map. Eighty-six QTL for yield components, PH, and yield-related physiological traits were detected on 18 chromosomes except 1D, 5D, and 6D, explaining 2.3–33.2% of the phenotypic variance. Ten stable QTL were identified across four environments, viz. QTKW.caas-6A.1, QTKW.caas-7AL, QKNS.caas-4AL, QSN.caas-1AL.1, QPH.caas-4BS.2, QPH.caas-4DS.1, QSL.caas-4AS, QSL.caas-4AL.1, QChl-A.caas-5AL, and QChl-10.caas-5BL. Meanwhile, 10 QTL-rich regions were found on chromosome 1BS, 2AL (2), 3AL, 4AL (2), 4BS, 4DS, 5BL, and 7AL exhibiting pleiotropic effects. These QTL or QTL clusters are tightly linked to SNP markers, with genetic distances to the closest SNPs ranging from 0 to 1.5 cM, and could serve as target regions for fine mapping, candidate gene discovery, and MAS in wheat breeding.
Influence of diet and exercise on skeletal muscle and visceral adipose tissue in men.

The effects of diet only (DO) and diet combined with either aerobic (DA) or resistance (DR) exercise on subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), lean tissue (LT), and skeletal muscle (SM) tissue were evaluated in 33 obese men (DO, n = 11; DA, n = 11; DR, n = 11). All tissues were measured by using a whole body multislice magnetic resonance imaging (MRI) model. Within each group, significant reductions were observed for body weight, SAT, and VAT (P < 0.05). The reductions in body weight (approximately 10%) and SAT (approximately 25%) and VAT volume (approximately 35%) were not different between groups (P > 0.05). For all treatments, the relative reduction in VAT was greater than in SAT (P < 0.05). For the DA and DR groups only, the reduction in abdominal SAT (approximately 27%) was greater (P < 0.05) than that observed for the gluteal-femoral region (approximately 20%). Conversely, the reduction in VAT was uniform throughout the abdomen regardless of treatment (P > 0.05). MRI-LT and MRI-SM decreased both in the upper and lower body regions for the DO group alone (P < 0.05). Peak O2 uptake (liters) was significantly improved (approximately 14%) in the DA group as was muscular strength (approximately 20%) in the DR group (P < 0.01). These findings indicate that DA and DR result in a greater preservation of MRI-SM, mobilization of SAT from the abdominal region, by comparison with the gluteal-femoral region, and improved functional capacity when compared with DO in obese men.
Dental Caries Prevalence and Tooth Loss in Chilean Adult Population: First National Dental Examination Survey

The purpose of this study was to assess the prevalence of dental caries, tooth loss, and risk factors among adult population of Chile. Furthermore, age, gender, and behavioural specific differences in caries prevalence and tooth loss were examined. A national stratified multistage probabilistic sample design in two-age cohorts was applied to the Chilean population. A sample of 1553 adults, comprising 1088 individuals aged 35–44 and 465 senior individuals aged 65–74, were examined. The DMFT was evaluated following WHO recommendations using diagnostic criteria of caries lesions into dentin. The data were analyzed by univariate and multivariate models using logistic regression analyses. Results showed a mean DMFT of 15.06 in the 35–44-year-old group and of 21.57 in the 65–74 group. Factors related to tooth loss in the 35–44 group through univariate logistic regression were depression (OR 1.9 CI 95% 1.26–2.85), education level <12 years (OR 2.24 CI 95% 1.31–3.73), personal income (OR 1.51 CI 95% 1.04–2.19), and familiar income (OR 2.05 CI 95% 1.34–3.13), and through multivariate logistic regression in the same age group were depression (OR 1.93 CI 95% 1.24–3.0), education level <12 years (OR 1.94 CI 95% 1.2–3.14), and familiar income (OR 1.71 CI 95% 1.09–2.68). Factors related to tooth loss in the 65–74-year-old group through univariate logistic regression were education level <12 years (OR 2.54 CI 95% 1.3–4.96) and personal income (OR 1.66 CI 95% 1.05–2.63), and for multivariate logistic regression in the same age group, it was education level <12 years (OR 2.51 CI 95% 1.21–5.18). In conclusion, adult population in Chile showed a high prevalence of dental caries and tooth loss, as age, education level, personal and familiar incomes, and depression are being the main risk factors.
Repeating pattern discovery and structure analysis from acoustic music data

Music and songs usually have repeating patterns and prominent structure. The automatic extraction of such repeating patterns and structure is useful for further music summarization, indexing and retrieval. In this paper, an effective approach of repeating pattern discovery and structure analysis of acoustic music data is proposed. In order to represent the melody similarity more accurately, in our approach, Constant Q transform is utilized in feature extraction and a novel similarity measure between musical features is proposed. From the self-similarity matrix of the music, an adaptive method is then presented to extract all significant repeating patterns. Based on the obtained repetitions, musical structure is further analyzed using a few heuristic rules. Finally, an optimization-based approach is proposed to determine the accurate boundary of each musical section. Evaluations on various music pieces indicate our approach is promising.
Strategies Towards Meeting Future Particulate Matter Emission Requirements in Homogeneous Gasoline Direct Injection Engines

Since the introduction of the EURO 5 emission legislation particulate matter emissions are no longer only a concern in the development of Diesel engine powertrains. In addition to particulate mass (PM) requirements the new European legislation will also foresee the implementation of a particulate number (PN) requirement for all spark ignition (SI) vehicles with the introduction of EURO 6. Measurements with state of the art gasoline engine powered vehicles show that conventional MPFI engines are already below the future proposed limits while gasoline engines with direct injection are above these limits and will require additional development efforts. This paper discusses both fuel system component requirements as well as control strategies in support of reducing particulate emissions. On the component side, mixture formation in regard to evaporation rate and penetration is a key factor. On the control side, injection timing and injection splitting are important parameters, especially under cold catalyst heating conditions. Encouraging test results show that significant improvements in regard to particulate matter emissions can be made. For the particulate mass emission a value significantly lower than the proposed limit can be achieved, while the proposed particulate number limit is significantly more challenging. The demonstrated vehicle results detailed below show that the proposed EURO 6 targets can be met by gasoline engines with direct injection by careful further optimization of the involved hardware and calibration without adding an additional after-treatment system.
Supporting smart electric vehicle charging with information-centric networking

Inspired by the proliferation of content-centric applications in the Internet, Information-Centric Networking (ICN) has emerged as a promising networking paradigm. Focusing on the delivery of content instead of the pairwise communication between end-hosts, ICN inherently supports location-independent content/information distribution, through the means of in-network caching and multicast; as well as mobile computing. However, so far the vast majority of ICN research efforts have mostly focused on the design of sound and scalable architectures and protocols for the current Internet application landscape. In this paper, we revisit ICN in the context of a radically different application environment of smart grids and in particular, the case of smart charging of electric vehicles. Based on a thorough description of the currently forming application environment in the Netherlands, we highlight the inefficiencies resulting from a host-centric model. We then show how ICN can address these limitations and ultimately support quality and security in such application environment. Besides qualitative benefits, our preliminary analysis also demonstrates that ICN can substantially reduce communication and security complexity, thus fostering the development and widespread adoption of the smart charging application.
Type 0A matrix model of a black hole, integrability, and holography

We investigate a deformed matrix model of type 0A theory related to supersymmetric Witten's black hole in two-dimensions, a generalization of bosonic model suggested by Kazakov et al. We find a free field realization of the partition function of the matrix model, which includes Ramond-Ramond perturbations in the type 0A theory. In a simple case, the partition function is factorized into two determinants, which are given by {tau} function of an integrable system. We work out the genus expansion of the partition function. Holographic relation with the supersymmetric Witten's black hole is checked by Wilson line computation. The corresponding partition function of the matrix model exhibits a singular behavior, which is interpreted as the point of enhanced N=2 world sheet supersymmetry. An interesting relation between the deformed matrix model and topological string on a Z{sub 2} orbifold of conifold is found.
Characterization of the Biophysical and Motility Properties of Kinesin from the Fungus Neurospora crassa(*)

Neurospora kinesin (Nkin) is a distant relative of the family of conventional kinesins, members of which have been identified in various animal species. As in its animal counterparts, Nkin most likely is an organelle motor. Because it is a functional homologue of the kinesin heavy chain of higher eukaryotes, its biophysical and motility properties were compared with those of other conventional kinesins. Purified Nkin behaves as a homodimeric complex composed of two subunits of a 105-kDa polypeptide. Based on its hydrodynamic properties (Stokes radius and sedimentation coefficient), Nkin is an elongated molecule, although it is more compact than its animal counterparts. A detailed comparison of the motility properties of Nkin with those of animal conventional kinesins reveals similarities and some intriguing differences. Nkin is less effective than other kinesins in the use of natural nucleoside triphosphates but responds to a selection of ATP analogues in a similar fashion as mammalian kinesin. Even in the presence of saturating concentrations of ATP, Nkin is significantly more sensitive to ADP or tripolyphosphate than other kinesins. Both the ATP-driven microtubule gliding activity and the microtubule-stimulated ATPase activity of Nkin obey Michaelis-Menten kinetics. Surprisingly, however, the K values for both these activities are approximately an order of magnitude higher than those of other kinesins. Whether the low affinity for ATP suggested by these high K values is related to the high rate of motility remains to be determined.