Miracle-dz/UniFAR-FTUs huggingface dataset:
Graphs of Edge-Intersecting Non-Splitting Paths in a Tree: Representations of Holes-Part II

Given a tree and a set P of non-trivial simple paths on it, VPT(P) is the VPT graph (i.e. the vertex intersection graph) of the paths P, and EPT(P) is the EPT graph (i.e. the edge intersection graph) of P. These graphs have been extensively studied in the literature. Given two (edge) intersecting paths in a graph, their split vertices is the set of vertices having degree at least 3 in their union. A pair of (edge) intersecting paths is termed non-splitting if they do not have split vertices (namely if their union is a path). We define the graph ENPT(P) of edge intersecting non-splitting paths of a tree, termed the ENPT graph, as the graph having a vertex for each path in P, and an edge between every pair of vertices representing two paths that are both edge-intersecting and non-splitting. A graph G is an ENPT graph if there is a tree T and a set of paths P of T such that G=ENPT(P), and we say that is a representation of G. Our goal is to characterize the representation of chordless ENPT cycles (holes). To achieve this goal, we first assume that the EPT graph induced by the vertices of an ENPT hole is given. In [2] we introduce three assumptions (P1), (P2), (P3) defined on EPT, ENPT pairs of graphs. In the same study, we define two problems HamiltonianPairRec, P3-HamiltonianPairRec and characterize the representations of ENPT holes that satisfy (P1), (P2), (P3). In this work, we continue our work by relaxing these three assumptions one by one. We characterize the representations of ENPT holes satisfying (P3) by providing a polynomial-time algorithm to solve P3-HamiltonianPairRec. We also show that there does not exist a polynomial-time algorithm to solve HamiltonianPairRec, unless P=NP.
Mothers' Reactions to Children's Negative Emotions: Relations to Children's Temperament and Anger Behavior.

The relation was studied between mothers'reactions to children's negative emotion and children's temperament and anger behaviors. Mothers reported their reactions to their 4- and 6-year-old children's negative emotions in a variety of contexts; mothers and school personnel rated children's dispositional emotional intensity, negative affectivity, and attentional regulation; and children's behaviors when angered were observed at school
Transformative Theatre: The Final Act of Living Well

“Vesta” is a one-act play about death and dying that was used as an educational tool and vehicle for engaging university students and creating public dialogue about end-of-life issues. This article discusses the pedagogical approaches (i.e., service learning, theatre of the oppressed) for the project, the creative process as a “rehearsal for reality” through experiential learning, and the transformative impact of the arts in changing perceptions of end-of-life choices. “Vesta” is about the struggles of an older woman to maintain dignity while surrendering personal autonomy, dealing with the medical establishment, and coping with a family finding it hard to let go. “Vesta” provides a unique context for intergenerational learning and public dialogue on the difficult topic of death and dying.
Depurative capacity of molecular adsorbent recycling system (MARS): A focus on bilirubin removal

The molecular adsorbent recycling system (MARS) is now widely used in the treatment of patients with hepatic failure (HF). A great deal of interest has been directed toward its effect on clinical outcome, whereas its depurative capacity also needs attention. Bilirubin, a tightly albumin-bound toxin accumulating in patients with HF, is regarded as a surrogate to evaluate the depurative capacity of albumin-bound toxins by blood purification modalities. The removal of bilirubin by MARS is difficult to predict, because both the clearance of bilirubin and the reduction ratio of bilirubin after a single session differ between patients and sessions. A reduction of depurative capacity over the course of a treatment is observed. Furthermore, the later sessions are likely less efficient than previous ones. It cannot be taken for granted that the reduction of depurative capacity is due to the saturation and reduced efficiency of the adsorbent columns used in MARS. The answer lies in the property of bilirubin/albumin binding. The removal of bilirubin by MARS is a diffusion process, dependent on the free bilirubin concentration. Bilirubin binds to albumin in 3 ways with different affinity. High-affinity binding bilirubin is difficult to dissociate from albumin and is accompanied by a smaller free fraction, which means it is also difficult for MARS to remove. The factors affecting the free fraction of bilirubin will impact on bilirubin removal by MARS. Among them, the molar ratio of bilirubin to albumin is the most important one. Other factors include the interaction of other agents with bilirubin/albumin binding, the albumin concentration, plasma ion strength, and pH.
Role of Tomato Lipoxygenase D in Wound-Induced Jasmonate Biosynthesis and Plant Immunity to Insect Herbivores

In response to insect attack and mechanical wounding, plants activate the expression of genes involved in various defense-related processes. A fascinating feature of these inducible defenses is their occurrence both locally at the wounding site and systemically in undamaged leaves throughout the plant. Wound-inducible proteinase inhibitors (PIs) in tomato (Solanum lycopersicum) provide an attractive model to understand the signal transduction events leading from localized injury to the systemic expression of defense-related genes. Among the identified intercellular molecules in regulating systemic wound response of tomato are the peptide signal systemin and the oxylipin signal jasmonic acid (JA). The systemin/JA signaling pathway provides a unique opportunity to investigate, in a single experimental system, the mechanism by which peptide and oxylipin signals interact to coordinate plant systemic immunity. Here we describe the characterization of the tomato suppressor of prosystemin-mediated responses8 (spr8) mutant, which was isolated as a suppressor of (pro)systemin-mediated signaling. spr8 plants exhibit a series of JA-dependent immune deficiencies, including the inability to express wound-responsive genes, abnormal development of glandular trichomes, and severely compromised resistance to cotton bollworm (Helicoverpa armigera) and Botrytis cinerea. Map-based cloning studies demonstrate that the spr8 mutant phenotype results from a point mutation in the catalytic domain of TomLoxD, a chloroplast-localized lipoxygenase involved in JA biosynthesis. We present evidence that overexpression of TomLoxD leads to elevated wound-induced JA biosynthesis, increased expression of wound-responsive genes and, therefore, enhanced resistance to insect herbivory attack and necrotrophic pathogen infection. These results indicate that TomLoxD is involved in wound-induced JA biosynthesis and highlight the application potential of this gene for crop protection against insects and pathogens.
Patterns of proteins synthesized in the R15 neuron of Aplysia. Temporal studies and evidence for processing

The time-course of changes in the pattern of newly synthesized proteins in the R15 neuron of the parietovisceral ganglion of Aplysia californica has been studied at 14 degrees C. 5% polyacrylamide gels containing sodium dodecyl sulfate (SDS) have been used to separate newly synthesized (leucine-labeled) proteins from the neuron. We have demonstrated that the pattern of newly synthesized proteins from the R15 neuron does not change significantly if 5-h pulses of labeled leucine are given during the first 72 h of in vitro incubation of the excised ganglion. However, the level of leucine incorporation begins to decline somewhere between 17 and 43 h after the ganglion is isolated; at 43 and 69 h the levels of incorporation fell to 29 and 10% of the initial level, respectively. A number of conclusions have been drawn from the use of a sequential, double-label type of experiment in the same cell. There is processing of SDS-soluble, 12,000-dalton (12k) material to 6,000-9,000-dalton (6-9k) material. These materials are the two major peaks on gels after long labeling periods and together account for about 35% of all newly synthesized proteins. After synthesis of 12k material, there is a gradual disappearance of 12k (half-life about 8 h) and simultaneous appearance of 6-9k material on the gels, as the postsynthesis "chase" period of ganglia incubation is increased. The processing of 12k to 6-9k material occurs even in the presence of anisomycin, a protein syntehsis inhibitor, during the chase period. While the rate of 12k to 6-9k conversion can vary from cell to cell, it appears to remain consistent within, and is characteristic of, any individual R15. We detect no circadian rhythm in either the rate of 12k synthesis or the rate of 12k to 6-9k processing with 5-h label periods. These results are discussed in relation to the roles of 12k and 6-9k material in the R15 neuron.
Superrigidity for irreducible lattices and geometric splitting

We prove general superrigidity results for actions of irreducible lattices on CAT(0) spaces; first, in terms of the ideal boundary, and then for the intrinsic geometry (including for infinite-dimensional spaces). In particular, one obtains a new and self-contained proof of Margulis' superrigidity theorem for uniform irreducible lattices in non-simple groups. The proofs rely on simple geometric arguments, including a splitting theorem which can be viewed as an infinite-dimensional (and singular) generalization of the Lawson–Yau/Gromoll–Wolf theorem. Appendix A gives a very elementary proof of commensurator superrigidity; Appendix B proves that all our results also hold for certain non-uniform lattices.
La identificación del talento en la formación profesional. Diseño y resultado de una estrategia

Taking as a point of starting the critical analysis of the used ways to identify the talent at Central University of Las Villas (UCLV), this research is oriented toward the design and implementation of a strategy to surpass the found deficiencies in this process. The Cultural-Historic approach is taken as the theoretical reference. The methodological implications derived of this position assess the novelty of the scientific proposition since the identification of talent is conceived as an analysis of learners´ educational needs centered on professional education. Asurvey of multiple cases is carried out to prove the effectiveness of this strategy. This allows from qualitative perspective to analysis the regularities and the particularities of talented performance opening the possibilities for the establishment of educational contexts focused on the development of talent.
The paraventricular nucleus: an important component of the central neurocircuitry regulating sympathetic nerve outflow.

AIM The sympathetic nervous system plays an important role in the regulation of physiological homeostasis under basal conditions and in response to acute and chronic stressors. It is known that multiple levels of the neuroaxis, including the paraventricular nucleus (PVN) of the hypothalamus, are involved in regulation of efferent sympathetic nerve discharge (SND). This review focuses on the role of the PVN in regulation of functional characteristics of efferent SND. RESULTS The available experimental evidence indicates that the level of efferent sympathetic nerve activity is altered after microinjection of numerous substances into the PVN, including excitatory amino acids, gamma-aminobutyric acid (GABAA) receptor agonists and antagonists, and PVN nitric oxide synthase inhibitors. In addition, antagonism of PVN GABAA receptors changes the pattern of synchronized discharge bursts in efferent sympathetic nerves and enhances the frequency-domain coupling between low-frequency bursts in sympathetic nerve pairs. Finally, PVN microinjections of excitatory amino acids (L-glutamate, D,L-homocysteic acid) have been shown to produce non-uniform changes in the level of efferent sympathetic nerve activity. CONCLUSION These findings support the concept that the PVN is an important component of the central neurocircuitry regulating functional characteristics (basal level of activity, bursting pattern, and relationships between discharges in nerves innervating different targets) of efferent sympathetic nerve outflow.
Structure and Physical Properties of NiO / Co 3 O 4 Nanoparticles

The thermal treatment method was employed to prepare nickel-cobalt oxide (NiO/Co3O4) nanoparticles. This method was attempted to achieve the higher homogeneity of the final product. Specimens of nickel-cobalt oxide were characterized by various experimental techniques, including X-ray diffraction (XRD), transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FTIR). X-ray diffraction results showed that there was no crystallinity in the predecessor, and it still had the amorphous phase. The formations of the crystalline phases of the nickel-cobalt oxide nanoparticles started from 350–500 ̋C, and the final products had different crystallite sizes ranging from 11–35 nm. Furthermore, the variation of DC conductivity (σdc), impedance, tangent loss (tgδ) and dielectric constant (ε1) of the calcined specimens with frequency in the range of 102–106 Hz was investigated. σdc showed a value of 1.9 ˆ 10 ́6 S/m, 1.3 ˆ 10 ́6 S/m and 1.6 ˆ 10 ́6 S/m for the specimens calcined at 350, 400 and 450 ̋C, respectively. Additionally, a decrease in tgδ values with an increase in temperature was observed. Finally, the formed nanoparticles exhibited ferromagnetic behaviors, which were confirmed by using a vibrating sample magnetometer (VSM).
A cross-cultural study of expressive and instrumental role complementarity in the family

Based on a representative cross-cultural sample of 186 societies, this research sought to extend an earlier investigation of specialization of the instrumental role, by sex, to a similar study of the expressive role in the family. A further aim of this research was the inspection of the Parsons and Bales proposition of complementarity of expressive and instrumental specialization. The results indicated that while women were strongly committed to expressive activities during the infancy of their children, the intensity of this commitment decreased substantially in early childhood. Males, while relatively less involved in expressive activities, still assumed a substantial portion of the expressive functions of the family, and maintained the level of this commitment throughout the infancy and early childhood of their offspring. A moderate level of male-female expressive complementarity was found in the infant caregiving activities; beyond infancy, however, the complementary relationship disappeared completely. Finally, no evidence was found to support a principle of complementary expressive-instrumental specialization in the family.
[Follow-up of adult women with Turner's syndrome in a cohort study in Utrecht].

OBJECTIVE To evaluate the follow-up of adult women with Turner's syndrome. DESIGN Cross-sectional study using questionnaires. METHOD In August 2005 questionnaires were sent to 5 adult women with Turner's syndrome who were known to the Wilhelmina Children's Hospital in Utrecht, The Netherlands. The questions concerned morbidity, follow-up and levels of satisfaction with care and the provision of information about Turner's syndrome. Case notes were also examined. RESULTS 38 questionnaires were returned, 19 from women aged 17-25 and 19 from women aged 26-42. 7 women had been without medical care for some time and 4 women were not receiving any medical care at the time of the study. The remaining women were being monitored by a general practitioner or one or more medical specialists. 6 of the 38 women were under the care of a cardiologist. 5 women had hypertension. 8 women had a renal malformation and, 5 of them were not having any renal follow-up. 8 women had undergone bone mineral density measurements in the preceding 5 years. The women between 17-25 years of age were more satisfied with the transfer of medical care from childhood to adulthood than those between 26-42 years of age. Most women felt they were well informed about Turner's syndrome. CONCLUSION Medical care for adult women with Turner's syndrome in our study group was less than optimal. Cardiovascular risks in particular needed more attention. We advocate a multidisciplinary approach for the follow-up of women with Turner's syndrome.
Angiographic computed tomography and computed tomographic angiography techniques: actual interventional and diagnostic possibilities of their use in patients with cerebral aneurysms

Since the introduction of radiological examination techniques, such as an angiographic computed tomography (ACT) and a computed tomographic angiography (CTA), the diagnosis and treatment planning for cerebral aneurysms became quicker and safer. Unfortunately, the state of development of these techniques, and their possible indications and benefits are still today restricted to specialized centers. The objective of this update was to analyze the current scientific evidence about their actual interventional and diagnostic use and identify the individual advantages of each through a literature review and personal experience-based data.
A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice

Toward drugging the undruggable in cancer Many human cancers are characterized by inappropriate activity of transcription factors. These proteins are attractive drug targets in principle, but normalizing their function requires drugs that modulate specific protein-protein interactions, a goal that has been challenging. In acute myeloid leukemia, a chromosomal translocation creates an aberrant form of the transcription factor CBF-beta, which outcompetes “normal” CBF-beta for binding to another transcription factor called RUNX1, thereby deregulating its activity. Illendula et al. identified and chemically optimized a small molecule that selectively disrupts the interaction between the aberrant CBF-beta and RUNX1 (see the Perspective by Koehler and Chen). This molecule restored normal gene expression patterns and delayed leukemia progression in mice. Thus, transcription factors may not be as undruggable as once thought. Science, this issue p. 779; see also p. 713 A small molecule inhibits leukemia in mice by targeting a transcription factor, a class of proteins thought to be undruggable. [Also see Perspective by Koehler and Chen] Acute myeloid leukemia (AML) is the most common form of adult leukemia. The transcription factor fusion CBFβ-SMMHC (core binding factor β and the smooth-muscle myosin heavy chain), expressed in AML with the chromosome inversion inv(16)(p13q22), outcompetes wild-type CBFβ for binding to the transcription factor RUNX1, deregulates RUNX1 activity in hematopoiesis, and induces AML. Current inv(16) AML treatment with nonselective cytotoxic chemotherapy results in a good initial response but limited long-term survival. Here, we report the development of a protein-protein interaction inhibitor, AI-10-49, that selectively binds to CBFβ-SMMHC and disrupts its binding to RUNX1. AI-10-49 restores RUNX1 transcriptional activity, displays favorable pharmacokinetics, and delays leukemia progression in mice. Treatment of primary inv(16) AML patient blasts with AI-10-49 triggers selective cell death. These data suggest that direct inhibition of the oncogenic CBFβ-SMMHC fusion protein may be an effective therapeutic approach for inv(16) AML, and they provide support for transcription factor targeted therapy in other cancers.
Inferring Multiple Activities of Mobile Users with Activity Algebra

This paper proposes a novel multiple activity recognition and reasoning approach where we use on-body sensor information along with other context information to infer mobile user activities which are both concurrent and interleaved. We develop and validate an activity algebra and a complex activity recognition algorithm for detecting these multiple activities. Activities are mapped onto situations using spatio-temporal analysis. We validate our approach by implementing a prototype and performing experiments in different scenarios using mobile devices.
Video-based face recognition using multiple face orientations

This work is focused on designing and implementing a real-time video-based face identification system with low memory and computational requirements and high recognition rates. Since pro le features are stronger and, therefore, better when characterising faces than frontal faces, the system will detect and identify not only pure frontal but also pro le faces. This property of pro le faces will help to improve face recognition rates depending on the strategy for fusion of results used. Also, dimensionality reduction techniques will be studied and tested in order to nd the fastest and most efective one. Modi cation in k Nearest Neighbor classi er will be carried out to add a penalisation factor in function of the distance, increasing classi cation results and strictness. In order to nd which are the best options for reducing computational requirements in a face identi cation system several simulations will be performed. Among many others, simulations will look for optimal values of the k parameter in k Nearest Neighbor, the number of transformed coe cients kept in a feature vector or the minimum size of face images and will test dimensionality reduction in images, variation of the number of models or fusion of results. Finally, this work will show how a real-time system can be implemented in an ordinary computer obtaining successful results whether it be in real-time, adverse or controlled conditions environments.
An NS5A single optimized method to determine genotype, subtype and resistance profiles of Hepatitis C strains

The objective was to develop a method of HCV genome sequencing that allowed simultaneous genotyping and NS5A inhibitor resistance profiling. In order to validate the use of a unique RT-PCR for genotypes 1–5, 142 plasma samples from patients infected with HCV were analysed. The NS4B-NS5A partial region was successfully amplified and sequenced in all samples. In parallel, partial NS3 sequences were analyzed obtained for genotyping. Phylogenetic analysis showed concordance of genotypes and subtypes with a bootstrap >95% for each type cluster. NS5A resistance mutations were analyzed using the Geno2pheno [hcv] v0.92 tool and compared to the list of known Resistant Associated Substitutions recently published. In conclusion, this tool allows determination of HCV genotypes, subtypes and identification of NS5A resistance mutations. This single method can be used to detect pre-existing resistance mutations in NS5A before treatment and to check the emergence of resistant viruses while undergoing treatment in major HCV genotypes (G1-5) in the EU and the US
A wireless power receiver with a 3-level reconfigurable resonant regulating rectifier for mobile-charging applications

A wireless power receiver using a 3-level reconfigurable resonant regulating (R3) rectifier is presented in this summary. The receiver improves power conversion efficiency and reduces die area and off-chip components by achieving power conversion and voltage regulation in one stage, using only 4 on-chip power switches and 1 off-chip capacitor. The receiver regulates the output voltage at 5 V and delivers a maximum power of 6 W. It was fabricated in a standard 0.35 μm CMOS process with a die area of 4.77 mm2, and the measured peak efficiency reaches 92.2%.