Miracle-dz/UniFAR-FTUs huggingface dataset:
Mammalian SUN Protein Interaction Networks at the Inner Nuclear Membrane and Their Role in Laminopathy Disease Processes*

The nuclear envelope (NE) LINC complex, in mammals comprised of SUN domain and nesprin proteins, provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity. SUN1 and SUN2 interact with lamin A, but lamin A is only required for NE localization of SUN2, and it remains unclear how SUN1 is anchored. Here, we identify emerin and short nesprin-2 isoforms as novel nucleoplasmic binding partners of SUN1/2. These have overlapping binding sites distinct from the lamin A binding site. However, we demonstrate that tight association of SUN1 with the nuclear lamina depends upon a short motif within residues 209–228, a region that does not interact significantly with known SUN1 binding partners. Moreover, SUN1 localizes correctly in cells lacking emerin. Importantly then, the major determinant of SUN1 NE localization has yet to be identified. We further find that a subset of lamin A mutations, associated with laminopathies Emery-Dreifuss muscular dystrophy (EDMD) and Hutchinson-Gilford progeria syndrome (HGPS), disrupt lamin A interaction with SUN1 and SUN2. Despite this, NE localization of SUN1 and SUN2 is not impaired in cell lines from either class of patients. Intriguingly, SUN1 expression at the NE is instead enhanced in a significant proportion of HGPS but not EDMD cells and strongly correlates with pre-lamin A accumulation due to preferential interaction of SUN1 with pre-lamin A. We propose that these different perturbations in lamin A-SUN protein interactions may underlie the opposing effects of EDMD and HGPS mutations on nuclear and cellular mechanics.
Multi output Active Clamped FlybackConverter

This paper presents the design of multioutput active clamp fly back converter topology which is operated at 100 KHz in CCM mode respectively. This provides output voltages (positive and negative), lower and higher voltages than input voltage. With the help of active clamp circuit, the transformer leakage energy is recycled, and zero-voltage-switching (ZVS) for primary main switch is achieved
Substance Use and Mental Health Treatment Retention among Young Adults

In Western and European cultures where marriage and parenthood are increasingly delayed to the late twenties and early thirties, a distinct developmental stage between adolescence and adulthood has been described as “emerging” or “young” adults. Development theory suggests that these “younger” adults have less social control and exercise higher levels of impulsivity and risky behavior than their older counterparts. This study examined the effect of age on treatment retention among adults with co-occurring substance use and mental health disorders enrolled in private, residential treatment. Study participants included 929 adults (198 young adults, 18-25 years, and 761 older adults, ≥ 26 years) receiving private residential treatment in the U.S. Bivariate analyses, life tables, and Cox regression (survival analyses) were used to examine the effects of age on treatment retention.
CULTURE IN THE COUNTRYSIDE: A STUDY OF ECONOMIC DEVELOPMENT AND SOCIAL CHANGE IN PRINCE EDWARD COUNTY, ONTARIO

In 1951, over 38 percent of Canada’s population was classified as ‘rural. ’ During the next 50 years, however, that figure had fallen to 16 percent (Bryant and Joseph, 2001, 132), so Rural Canada has moved from a position of national centrality to one of marginality. Today, many rural communities are experiencing economic and social hardships caused by restructuring, the decline of rural industries and the flight of capital. The rural development problem is a byproduct of these hardships and involves aging populations, the outflow of young people and agricultural restructuring with adjustments including a decline in the number of farms and farmers, but not, however, the overall productiveness of the agricultural sector. These problems have led to the loss in many rural communities of critical services like schools, churches and medical clinics, along with a shrinking tax base. To mitigate these negative effects municipalities are turning to a variety of community economic development (CED) initiatives including culturally driven strategies to attract capital and create a new economic base.
Preface : Language and Communication in International Management

In international management, a substantial body of research is concerned with various aspects of communication across cultural and linguistic boundaries. For example, control and coordination of headquarters–subsidiary and intersubsidiary relationships, management of diverse teams, and knowledge transfer within internationally operating firms, all touch upon the notion of communication. While there has been a “linguistic turn” in some of the recent organization behavior and management literature (see, e.g., Tietze, Cohen, and Musson 2003; Academy of Management Review 2004), the role of language in international business has been deemed “the most neglected field in management” (Reeves and Wright 1996), and “the forgotten factor” (Marschan-Piekkari, Welch, and Welch 1997: 591). In retrospect, language was identified as a factor in some of the early international business research (e.g., Johansson and Wiedersheim-Paul 1975), but it has only recently been rediscovered. International business communication is a rich field of study, and the current knowledge of cross-cultural or multilingual communication in international management has been influenced by linguists’ and organizational researchers’ work (see, e.g., Bargiela-Chappini and Nickerson 2001 for a review). Research on language in international management has predominantly focused on the types of solutions that companies opt for when moving from monolingual to multilingual business contexts. For example, scholars studied how small and medium-sized companies respond to increasing language requirements when serving overseas customers (e.g., Crick 1999). Some internationalizing companies reacted to these requirements by
The association of second trimester biomarkers in amniotic fluid and fetal outcome

Abstract Objective: To identify the level of amniotic fluid lactate (AFL), placental growth factor (PLGF), and vascular endothelial growth factor (VEGF) at second trimester amniocentesis, and to compare levels in normal pregnancies with pregnancies ending in a miscarriage, an intrauterine growth restricted fetus (IUGR) or decreased fetal movements. Study design: A prospective cohort study. Amniotic fluid was consecutively collected at amniocentesis in 106 pregnancies. Fetal wellbeing at delivery was evaluated from medical files and compared with the levels of AFL, VEGF, and PLGF at the time of amniocentesis. Results: The median level of AFL was 6.9 mmol/l, VEGF 0.088 pg/ml, and PLGF 0.208 pg/ml. The median levels of AFL in pregnancies ended in miscarriage were significantly higher (10.7 mmol/l) compared to those with a live new-born (6.9 mmol/L, p = .02). The levels of VEGF (p = .2) and PLGF (p = .7) were not affected. In pregnancies with an IUGR, the median level of AFL was higher compared to those with normal fetal growth (p = .003). No differences VEGF (p = .5), but significant lower PLGF were found in IUGR pregnancies (p = .03). Conclusions: Pregnancies ending in a miscarriage or with IUGR had significantly higher median values of AFL but lower values of PLGF in the amniotic fluid at the time of second trimester amniocentesis compared to normal pregnancies.
ASIE Model: An Innovative Instructional Design Model for Teachers in Enhancing and Sustaining the Quality of the 21st Century Learning

An effective and systematic design of instruction will determine the quality of learning and teaching practices. Hence, instructional design models are required, to move from just adopting a standard approach to developing models that have an impact on learners’ profiles, creating a much better learning experience, skills, and knowledge both in the classroom and online. The 21st Century Learning Framework requires learners to develop their thinking skills, communication skills, collaborating skills and enhancing their creativity, (4Cs) towards establishing “globally competitive learners. ” An Integral ASIE Instructional Design Model is an innovative 21st Century teachers’ designing tool that provides a solution to the above challenges. The Model assist teachers in Planning, Utilizing and Sharing (PLUS) instructions with others across nations. It promotes the Professional Learning Community practices where educationist, stakeholders, parents, and corporates work collaboratively ensuring its quality and sustainability in addressing the future employability issues of the learners. Results from 5 Likert Scales Questionnaires given to teachers in workshops and pilot project conducted, shows positive views on the model.
Design automation of a fully differential switched capacitor amplifier using a telescopic cascode OTA

In this paper, we propose a design procedure and an automated design flow for a fully differential switched capacitor amplifier. The proposed procedure uses the gm/ID design methodology, which relies on searching lookup tables pre-generated from accurate simulation models. A set of specifications including power consumption, noise, bandwidth, gain, static error, and output swing is used to constrain the design process. The operational transconductance amplifier (OTA) is implemented using a telescopic cascode architecture. The automation program is written in MATLAB and is capable of generating sizing parameters, writing circuit netlists, running simulations, and displaying and analyzing simulation results. A design example is used to verify the proposed program, where Cadence Spectre is used to verify the achievement of the required circuit specifications.
Stepping toward standard methods of small-signal parameter extraction for HBTs

An improved HBT small-signal parameter extraction procedure is presented in which all the equivalent circuit elements are extracted analytically without reference to numerical optimization. Approximations required for simplified formulae used in the extraction routine are revised, and it is shown that the present method has a wide range of applicability, which makes it appropriate for GaAs and InP-based single and double HBTs. Additionally, a new method is developed to extract the total delay time of HBTs at low frequencies, without the need to measure h/sub 21/ at very high frequencies and/or extrapolate it with -20 dB/dec roll-off. The existing methods of finding the forward transit time are also modified to improve the accuracy of this parameter and its components. The present technique of parameter extraction and delay time analysis is applied to an InGaP/GaAs DHBT and it is shown that: (1) variations of all the extracted parameters are physically justifiable; (2) the agreement between the measured and simulated S- and Z-parameters in the entire range of frequency is excellent; and (3) an optimization step following the analytical extraction procedure is not necessary. Therefore, we believe that the present technique can be used as a standard extraction routine applicable to various types of HBTs.
Analytical solutions to slender-ribbon theory

The low-Reynolds number hydrodynamics of slender ribbons is accurately captured by slender-ribbon theory, an asymptotic solution to the Stokes equation which assumes that the three length scales characterising the ribbons are well separated. We show in this paper that the force distribution across the width of an isolated ribbon located in a infinite fluid can be determined analytically, irrespective of the ribbon's shape. This, in turn, reduces the surface integrals in the slender-ribbon theory equations to a line integral analogous to the one arising in slender-body theory to determine the dynamics of filaments. This result is then used to derive analytical solutions to the motion of a rigid plate ellipsoid and a ribbon torus and to propose a ribbon resistive-force theory, thereby extending the resistive-force theory for slender filaments.
Improving Tanzanian childbirth service quality

Purpose The purpose of this paper is to describe a quality improvement (QI) intervention in primary health facilities providing childbirth care in rural Southern Tanzania. Design/methodology/approach A QI collaborative model involving district managers and health facility staff was piloted for 6 months in 4 health facilities in Mtwara Rural district and implemented for 18 months in 23 primary health facilities in Ruangwa district. The model brings together healthcare providers from different health facilities in interactive workshops by: applying QI methods to generate and test change ideas in their own facilities; using local data to monitor improvement and decision making; and health facility supervision visits by project and district mentors. The topics for improving childbirth were deliveries and partographs. Findings Median monthly deliveries increased in 4 months from 38 (IQR 37-40) to 65 (IQR 53-71) in Mtwara Rural district, and in 17 months in Ruangwa district from 110 (IQR 103-125) to 161 (IQR 148-174). In Ruangwa health facilities, the women for whom partographs were used to monitor labour progress increased from 10 to 57 per cent in 17 months. Research limitations/implications The time for QI innovation, testing and implementation phases was limited, and the study only looked at trends. The outcomes were limited to process rather than health outcome measures. Originality/value Healthcare providers became confident in the QI method through engagement, generating and testing their own change ideas, and observing improvements. The findings suggest that implementing a QI initiative is feasible in rural, low-income settings.
Institutional Herding and Information Cascades: Evidence from Daily Trades

Using daily trade and quote data, we test whether institutional trading patterns are consistent with Avery and Zemsky’s (1998) theoretical model of information cascades. Consistent with theory, we find variables proxying for information asymmetry to positively predict increased levels of institutional herding at high frequencies and that herding levels increase when estimated over shorter horizons. Days with high levels of herding are subsequently followed by price reversals but these are limited to those stocks where trading is believed to be informative. The paper also shows that the daily trade and quote data provides similar estimates of herding as previously estimated from quarterly holdings data.
Reframing Engagement Methods for Climate Change Adaptation

Climate change poses known and unknown risks for coastal communities and also challenges for university faculty and local government staff who communicate about cli- mate sciences. Conceived as a way to move beyond traditional models of science communication, this project involved public and private decision makers in specific at-risk communities in Oregon (U.S. Pacific coast) and Maine (Atlantic coast). Both state projects sought to move behavior toward decisive action that results in coastal communities that are more resilient to climate variability at all scales. To promote engagement between project staffs and publics, a dialogic model of communication was advanced, beginning with interviews and focus groups that in turn shaped further engagement through workshops and targeted video products. This means of communication led to a deeper understanding of participants’ knowledge, beliefs, perceptions, values, and barriers to action related to climate change and its effects. Coinciding with this, project participant evaluations in both Oregon and Maine indicate that the workshops and videos were successful at informing them on this complex issue; and in both states, project participation led to action outcomes. We believe that applied elsewhere our multifaceted and adaptive approach will garner similar results, provided sufficient dedicated staffing and attention to methods.
Choix des consommateurs et libéralisation des marchés de l'électricité

Pendant des decennies, les menages n’ont eu qu’un role passif a jouer dans l’organisation des systemes electriques et gaziers. Avec la liberalisation progressive des marches electriques et gaziers, la place et le role des consommateurs evoluent peu a peu. D’usagers, ils se muent en clients ayant un role plus actif a jouer dans l’evolution des systemes energetiques. Cette evolution ne va pas sans soulever un certain nombre de questions. Car si les clients sont amenes a jouer un role plus actif, ils seront egalement conduits a prendre de nouveaux risques, qui ne pesent pas de maniere egale sur tous les consommateurs. Se pose alors la question de l’intervention publique dans ce nouveau contexte : faut-il imaginer des mecanismes de sauvegarde pour certaines categories sociales qui ne beneficient plus du caractere protecteur du tarif reglemente ? Si oui, lesquels sont les plus efficaces et les mieux cibles ? Cet article tente de donner de premiers elements de reponse a ces interrogations qui renvoient, in fine, a l’equite des reformes en cours et a leur acceptation sociale.
Extreme sports in natural areas: looming disaster or a catalyst for a paradigm shift in land use planning?

Historically, visitors’ motives for visiting protected areas included ‘rest, relaxation and reinvigoration’. Ecological impacts were typically low. Recent trends have increased use of protected areas for extreme sports, with greater numbers undertaking more active recreation, such as extreme sports. The effect of this trend is considered, together with potential management options. We propose that the development of appropriately targeted and delivered educational programmes could minimise environmental degradation. However, to maximise ecological conservation in protected lands we consider that a major paradigm shift is required. This will require a more strategic, holistic approach to planning and managing outdoor recreation/sport destinations incorporating collaboration across stakeholders. Based on past experience, to continue with the current model will ultimately accelerate biodiversity loss, degradation of protected areas, and loss of recreational amenity.
The effect of a complex training and detraining programme on selected strength and power variables in early pubertal boys

Abstract Complex training, a combination of resistance training and plyometrics is growing in popularity, despite limited support for its efficacy. In pre- and early pubertal children, the study of complex training has been limited, and to our knowledge an examination of its effect on anaerobic performance characteristics of the upper and lower body has not been undertaken. Furthermore, the effect of detraining after complex training requires clarification. The physical characteristics (mean±s) of the 54 male participants in the present study were as follows: age 12.3 ± 0.3 years, height 1.57 ± 0.07 m, body mass 50.3 ± 11.0 kg. Participants were randomly assigned to an experimental (n = 33) or control group (n = 21). The training, which was performed three times a week for 12 weeks, included a combination of dynamic constant external resistance and plyometrics. After training, participants completed 12 weeks of detraining. At baseline, after training and after detraining, peak and mean anaerobic power, dynamic strength and athletic performance were assessed. Twenty-six participants completed the training and none reported any training-related injury. Complex training was associated with small increases (≤5.5%) in peak and mean power during training, followed by decreases of a similar magnitude (≤ −5.9%) during detraining (P < 0.05). No changes or minor, progressive increases (≤1.5%) were evident in the control group (P > 0.05). In the experimental group, dynamic strength was increased by 24.3 – 71.4% (dependent on muscle group; P < 0.01), whereas growth-related changes in the control group varied from 0 to 4.4% (P > 0.05). For 40-m sprint running, basketball chest pass and vertical jump test performance, the experimental group saw a small improvement (≤4.0%) after training followed by a decline (≤ −4.4%) towards baseline during detraining (P < 0.05), whereas the control group experienced no change (P > 0.05). In conclusion, in pre- and early pubertal boys, upper and lower body complex training is a time-effective and safe training modality that confers small improvements in anaerobic power and jumping, throwing and sprinting performance, and marked improvements in dynamic strength. However, after detraining, the benefits of complex training are lost at similar rates to other training modalities.
Population and Policy in Marshall's Economics

The Malthusian population doctrine formed an integral part of both theory and policy in classical economics: “[T]he Malthusian theory lent support to the subsistence theory of wages and prepared the way for the Ricardian preoccupation with the land-using bias of economic progress; by explaining poverty in terms of a simple race between population and the means of subsistence, it provided the touchstone for all classical thinking about economic policy” (Blaug 1997, p. 65). Among historians of economic thought there is probably little in this statement with which to disagree. A variety of interpretations, however, have been given to the subsequent career of the population doctrine, including its place in the economics of Alfred Marshall. Economists after John Stuart Mill, Joseph Schumpeter argued, found the population doctrine to be of little theoretical use to economics: many leading economists of the neoclassical school, including Alfred Marshall, “paid their respects to it, even though they no longer based upon it any part of their analytic structures” (1954, p. 890). Mark Blaug, by contrast, suggests that the analysis of population in Marshall's Principles of Economics indicates an “orthodox classical attitude to population problems” (1997, p. 385). Yet another perspective is offered by John Whitaker who remarks that early in his career Marshall resolved to transform the “old political economy into a new science of economics, open to the progressive intellectual and social movements of the day. ” His intent was to leave behind the sterile controversies and pessimistic pronouncements of the old political economy, including those associated with the population doctrine (1996, vol. 1, pp. xvii, xx).
The Missing Dimensions of Poverty Data: An Introduction

The aim of this paper is to draw attention to ‘missing dimensions’ of poverty data – dimensions that are of value to poor people, but for which we have scant or no data. Amartya Sen frames development as the process of expanding the freedoms that people value and have reason to value. Although the most widely-known measure of human development includes income, longevity, and education, many have argued that people’s values, and consequently multidimensional poverty, extends beyond these domains. In order to advance these multiple areas, it is at times necessary to conduct empirical studies using individual or household-level data on multiple dimensions of poverty. A critical barrier for international analyses of multidimensional poverty is that few or no high-quality indicators are available across countries and respondents in key domains that are deeply important to poor people and of potentially critical instrumental importance.