Miracle-dz/UniFAR-FTUs huggingface dataset:
Study on establishment of product life cycle model of cultural creative product industrialization

The study aimed to probe into the establishment of the product life cycle model of cultural creative product industrialization. It proposed related opinions for the theory based on the analysis of and discussions on documents and data. Moreover, based on the results of case study and in-depth interviews, the study integrated the product life cycle with the industrial and industrialization theory to construct the life cycle model of cultural creative product industrialization. The characteristics of cultural creative product industrialization in each management stage and meanings behind it could be comprehended through the model, and it can serve as references for enterprises in designing and developing cultural creative products and in planning management strategies. The findings of the study are as follows: (1) The concept of integrating cultural creative product industrialization with the product life cycle was feasible as each industrialization stage of products could be probed into in depth to adjust strategies to adapt to the change of environment, (2) The product life cycle process of cultural creative product industrialization chiefly includes introduction stage, growth stage, maturity stage and decline stage; (3) The strategies of each stage of the product life cycle: “introduction stage—innovation and creativity-oriented,” “growth stage—quality maintenance and product diversity-oriented,” “maturity stage—product renewal and new product development-oriented;” “decline stage—product function improvement-oriented. ”
Autonomous Memory Block for reconfigurable computing

Current FPGAs include large blocks of memory that require separate address generation circuits. This not only uses logic resources surrounding the memory blocks, but also results in unnecessary routing congestions. This paper proposes the integration of the address generation circuit into the block memory to form an Autonomous Memory Block (AMB). Quantitative comparison between using AMB and conventional FPGA block memory architectures demonstrates that this approach is promising.
TS-Hadoop: Handling access skew in MapReduce by using tiered storage infrastructure

Over the last few years, MapReduce systems has become popular for processing large-scale data sets and are increasingly being used in web indexing, data mining, and machine learning. Unlike simple application scenarios such as word count, many applications of MapReduce exhibit strong skewed access patterns in real production environment, the data access is non-uniform, often only a small portion of data are accessed far more frequently than others. Clearly, handling these hot data efficiently is quite critical to the overall performance of the MapReduce computation. In this paper, we present TS-Hadoop, a MapReduce system based on Apache Hadoop. The most significant feature of TS-Hadoop is that it utilizes tiered storage infrastructure, besides HDFS, TS-Hadoop also has a shared-disk cluster called HCache, it can be guaranteed that the data in HCache could be processed in highly parallel way. TS-Hadoop automatically distinguish hot and cold data based on current workload, and move them into HCache and HDFS respectively, the hot data in HCache could would be processed efficiently. Experiments show that the average execution time of MapReduce jobs in TS-Hadoop is much faster than traditional Hadoop platform when facing access skew workloads.
An analysis of ring oscillator PUF behavior on FPGAs

Many studies have been directed to probe ring oscillator PUF's feasibility in the security field, but most of them suffer from the lack of global approach as they analyze the system isolated, giving an uncompleted theory about their behavior. This paper presents how adjacent hardware elements may affect PUF response, modifying their statistical characteristics and even masking the randomness of manufacturing process. This is a factor that should be taken into account when modeling the behavior of the ring oscillators in the PUF. Experimental results from Xilinx Spartan 3 FPGAs illustrate these issues.
Boosting universal speech attributes classification with deep neural network for foreign accent characterization

We have recently proposed a universal acoustic characterisation to foreign accent recognition, in which any spoken foreign accent was described in terms of a common set of fundamental speech attributes. Although experimental evidence demonstrated the feasibility of our approach, we belive that speech attributes, namely manner and place of articulation, can be better modelled by a deep neural network. In this work, we propose the use of deep neural network trained on telephone bandwidth material from different languages to improve the proposed universal acoustic characterisation. We demonstrate that deeper neural architectures enhance the attribute classification accuracy. Furthermore, we show that improvements in attribute classification carry over to foreign accent recognition by producing a 21% relative improvement over previous baseline on spoken Finnish, and a 5.8% relative improvement on spoken English. Index Terms: Deep neural networks, data-driven speech attributes, manner of articulation, place of articulation, i-Vector, foreign accent recognition
The meaning of HE in developing professional identities: some reflections on workbased foundation degrees and skill utilisation

In a climate of financial constraint there is increasing pressure on HE to justify its draw on the public purse. Viewing HE as investment in raising the skill level of the workforce raises the question of the effectiveness of that investment and understanding effective skill utilisation is therefore critical. In this paper, the authors argue that the relationship between experience, education and skill utilisation is more complex than notions of skill acquisition suggest and skill utilisation depends not on the ‘possession’ of skills but on the dynamic interaction through social practices between individual factors and the social context. Drawing on empirical work in the context of part‐time Foundation Degrees the authors report on how HE can be instrumental in shaping and transforming identities at work and argue for the need to research the role of HE in mediating social practices in the workplace to support skill utilisation.
Analysis of untyped SNPs: maximum likelihood and imputation methods

Analysis of untyped single nucleotide polymorphisms (SNPs) can facilitate the localization of disease‐causing variants and permit meta‐analysis of association studies with different genotyping platforms. We present two approaches for using the linkage disequilibrium structure of an external reference panel to infer the unknown value of an untyped SNP from the observed genotypes of typed SNPs. The maximum‐likelihood approach integrates the prediction of untyped genotypes and estimation of association parameters into a single framework and yields consistent and efficient estimators of genetic effects and gene‐environment interactions with proper variance estimators. The imputation approach is a two‐stage strategy, which first imputes the untyped genotypes by either the most likely genotypes or the expected genotype counts and then uses the imputed values in a downstream association analysis. The latter approach has proper control of type I error in single‐SNP tests with possible covariate adjustments even when the reference panel is misspecified; however, type I error may not be properly controlled in testing multiple‐SNP effects or gene‐environment interactions. In general, imputation yields biased estimators of genetic effects and gene‐environment interactions, and the variances are underestimated. We conduct extensive simulation studies to compare the bias, type I error, power, and confidence interval coverage between the maximum likelihood and imputation approaches in the analysis of single‐SNP effects, multiple‐SNP effects, and gene‐environment interactions under cross‐sectional and case‐control designs. In addition, we provide an illustration with genome‐wide data from the Wellcome Trust Case‐Control Consortium (WTCCC) [ 2007 ]. Genet. Epidemiol. 34:803–815, 2010. © 2010 Wiley‐Liss, Inc.
Mechanical Properties of Lead-Free Solders

Mechanical testing of solder joint arrays was used to characterize lead-free solder alloys under both shear and tensile loading. The alloys studied included Sn4.0Ag0. 5Cu, Sn3.5Ag, Sn0.7Cu, Sn3.0Ag0. 5Cu, and Sn1.2Ag0. 5Cu0.05Ni. All of the lead-free alloys exhibited time and temperature dependent creep behavior over the entire temperature range from -55 C to 125 C. A SINH creep law was effective in describing the steady state creep behavior over the entire range of conditions. Lead-free alloy strength increases with increasing Ag content. The relative strength of tin-lead versus lead-free alloys depends on the strain rate and temperature regime. At high strain rates and low temperatures, eutectic tin-lead is the strongest alloy. At low strain rates and high temperatures, eutectic tin-lead is the lowest strength alloy. Simulated stress-strain hysteresis loops for both accelerated test and field use conditions showed dramatic differences between the various alloys. Higher Ag content results in a larger stress range but a smaller strain range during temperature cycling.
Improving Event Extraction via Multimodal Integration

In this paper, we focus on improving Event Extraction (EE) by incorporating visual knowledge with words and phrases from text documents. We first discover visual patterns from large-scale text-image pairs in a weakly-supervised manner and then propose a multimodal event extraction algorithm where the event extractor is jointly trained with textual features and visual patterns. Extensive experimental results on benchmark data sets demonstrate that the proposed multimodal EE method can achieve significantly better performance on event extraction: absolute 7.1% F-score gain on event trigger labeling and 8.5% F-score gain on event argument labeling.
Factors of prognostic importance in childhood non‐hodgkin's lymphoma treated with two modified lsa2‐l2 protocols. A multivariate analysis approach

The results of therapy given to 74 children with advanced disease, abdominal non‐Hodgkin's lymphoma were retrospectively evaluated with respect to the major prognostic factors related to disease outcome. The first 36 patients admitted in the study were treated with a modified LSA2‐L2 protocol, and the remaining patients received the same regimen with the addition of intermediate‐dose methotrexate (MTX) intravenously during the induction phase (LSA2‐L2‐MTX). The last ten patients admitted were given a leucovorin rescue along with the administration of MTX. The relative efficacy of the LSA2‐L2‐MTX over the baseline LSA2‐L2 regimen was analyzed by multivariate statistical methods taking into consideration several candidate coprognostic factors. The risk of treatment failure was substantially reduced (55%) with the use of the LSA2‐L2‐MTX regimen. Rescue with leucovorin did not contribute a further significant gain in treatment efficacy, although fewer toxicity‐related problems were observed as compared to the no‐rescue period. Five prognostic factors emerged as significantly explanatory of the risk of treatment failure in addition to protocol type: lymphocyte count, disease stage, surgical debulking, sex, and nutritional status. Based on these variables, a logistic regression equation could be derived to identify groups that were at risk for treatment failure.
Clusterin: a key player in cancer chemoresistance and its inhibition

Clusterin is a heterodimeric disulfide-linked glycoprotein (449 amino acids) isolated in the rat prostate after castration. It is widely distributed in different tissues and highly conserved in species. There are two isoforms (1 and 2) with antagonistic actions regarding apoptosis. Clusterin is implicated in a number of biological processes, including lipid transport, membrane recycling, cell adhesion, programmed cell death, and complement cascade, representing a truly multifunctional protein. Isoform 2 is overexpressed under cellular stress conditions and protects cells from apoptosis by impeding Bax actions on the mitochondrial membrane and exerts other protumor activities, like phosphatidylinositol 3-kinase/protein kinase B pathway activation, modulation of extracellular signal-regulated kinase 1/2 signaling and matrix metallopeptidase-9 expression, increased angiogenesis, modulation of the nuclear factor kappa B pathway, among others. Its overexpression should be considered as a nonspecific cellular response to a wide variety of tissue insults like cytotoxic chemotherapy, radiation, excess of free oxygen radicals, androgen or estrogen deprivation, etc. A review of the recent literature strongly suggests potential roles for custirsen in particular, and proapoptosis treatments in general, as novel modalities in cancer management. Inhibition of clusterin is known to increase the cytotoxic effects of chemotherapeutic agents, and custirsen, a second-generation antisense oligonucleotide that blocks clusterin, is being tested in a Phase III clinical trial after successful results were achieved in Phase II studies. A major issue in cancer evolution that remains unanswered is whether clusterin represents a driving force of tumorigenesis or a late phenomenon after chemotherapy. This review presents preclinical data that encourages trials in various types of cancer other than advanced castration-resistance prostate cancer and discusses briefly the appropriate timing for clusterin inhibition in the clinical context.
A randomised multicentre trial of integrated versus standard treatment for patients with a first episode of psychotic illness

Objectives To evaluate the effects of integrated treatment for patients with a first episode of psychotic illness. Design Randomised clinical trial. Copenhagen Hospital Corporation and Psychiatric Participants 547 patients with first episode of schizophrenia spectrum disorder. Interventions Integrated treatment and standard treatment. The integrated treatment lasted for two years and consisted of assertive community treatment with programmes for family involvement and social skills training. Standard treatment offered contact with a community mental health centre. Main outcome measures Psychotic and negative symptoms (each scored from 0 to a maximum of 5) at one and two years’ follow-up. Results At one year’s follow-up, psychotic symptoms changed favourably to a mean of 1.09 (standard deviation 1.27) with an estimated mean difference between groups of –0.31 (95% confidence interval –0.55 to –0.07, P = 0.02) in favour of integrated treatment. Negative symptoms changed favourably with an estimated difference between groups of –0.36 (–0.54 to –0.17, P < 0.001) in favour of integrated treatment. At two years’ follow-up the estimated mean difference between groups in psychotic symptoms was –0.32 ( − 0.58 to –0.06, P = 0.02) and in negative symptoms was –0.45 (–0.67 to –0.22, P < 0.001), both in favour of integrated treatment. Patients who received integrated treatment had significantly less comorbid substance misuse, better adherence to treatment, and more satisfaction with treatment. Conclusion Integrated treatment improved clinical outcome and adherence to treatment. The improvement in clinical outcome was consistent at one year and two year follow-ups.
Glucagon-like peptide-1, a gastrointestinal hormone with a pharmaceutical potential.

Glucagon-like peptide-1 (GLP-1) is an insulinotropic hormone secreted from endocrine cells in the gut mucosa in response to meal ingestion. It is an important incretin hormone; mice with a null mutation in the GLP-1 receptor gene develop glucose intolerance. In addition, it inhibits gastrointestinal secretion and motility and is thought to be part of the "ileal brake" mechanism. Perhaps because of the latter actions it inhibits food intake, but intracerebral injection of GLP-1 also inhibits food intake. The insulinotropic effect is preserved in patients with type 2 diabetes mellitus, in whom also glucagon secretion is inhibited. Thus upon i.v. GLP-1 infusion blood glucose may be completely normalised. Because its actions are glucose-dependent hypoglycaemia does not develop. However, GLP-1 is metabolised extremely rapidly in vivo, initially by a mechanism that involves the enzyme dipeptidyl peptidase-IV. It is currently being investigated how GLP-1 or analogues thereof can be employed in practical diabetes therapy. Promising solutions include the development of stable analogues and inhibitors of the degrading enzyme.
GP attitudes to early diagnosis of dementia: Evidence of improvement

This paper offers a comparative analysis of GPs attitudes towards early diagnosis of dementia in 1997 and 2001. It draws on data from two studies conducted in the same area using the same research instrument. Overall, findings reveal a significantly greater commitment to early diagnosis at Time 2 than at Time 1. More GPs hold positive attitudes and consider early diagnosis to facilitate a number of practical and therapeutic benefits for users and carers. Further, fewer GPs regard early diagnosis as having negative consequences. Findings also support existing evidence about attitudes being underpinned by drivers and barriers. Those GPs who are committed regard it as an opportunity to offer preventive treatment and plan for the future; barriers include limited treatment options. Primary reasons for the attitudinal shift are greater accessibility of psychiatric colleagues, additional investment in support services, and enhanced policy and clinical emphasis on the value of early diagnosis.
Good (youth) sports: Using benefits-based programming to increase sportsmanship

Sportsmanship problems in youth sport have recently become a more prominent issue for parks and recreation professionals. Benefits-based programming is one method these professionals could use to address the issues of sportsmanship in their youth leagues. Recent studies and programs have successfully employed prosocial behavior techniques in this process as a means of improving the sportsmanship atmosphere in youth leagues. Previous research, however, has yet to compare the efficacy of such programs in comparison to a control group. Data for this study were gathered through observations of positive and negative sportsmanship behaviors youth basketball games at two local community centers. Three specific groups were involved: A control group (in which no intervention took place); PHPFPF only (in which prosocial behavior techniques were employed); and PHPFPF + refs (in which prosocial behavior techniques were employed along with referees trained in prosocial behavior). All games involved third through sixth graders and observations included players, coaches, and spectators. In addition, measures of fun were collected from participants at each game using a “fun-o-meter. ” Results suggest that intentional programming can be successfully employed to increase sportsmanship in youth sports. The youth sport league that did not utilize the benefits-based programming model displayed lower levels of positive sportsmanship and higher levels of negative sportsmanship for both age groups. The parks and recreation professionals at the second site, however, were able to develop a plan that enabled them to accomplish their goals by intentionally determining that sportsmanship and fun were two benefits being promoted in the league. Several lessons resulting from this study can be utilized in order to improve youth sport programs. Administrators who are hoping to create a more positive sportsmanship atmosphere may want to employ the benefits-based programming model. Furthermore, several of the prosocial behavior techniques employed in this study can be used to help professionals improve the sportsmanship in their leagues. A basic program was successfully used that was both easy and inexpensive to incorporate. An additional feature of training referees to use prosocial behavior can then be added for even greater results. By intentionally focusing their efforts on improving sportsmanship, both through increasing positive behaviors and decreasing negative ones, youth sport programs can be more fun for participants, which should lead to better overall experiences and hopefully help these youth to maintain participation in the future. ﻿
A Guided Tour in the Topos of Graphs

In this paper we survey the fundamental constructions of a presheaf topos in the case of the elementary topos of graphs. We prove that the transition graphs of nondeterministic automata (a.k.a. labelled transition systems) are the separated presheaves for the double negation topology, and obtain as an application that their category is a quasitopos.
Strong Normalizations of Substitutions

Acr-calculus is an extended A-calculus where substitutions are handled explicitly. It is similar to, and inspired by, Categorical Combinatory logic (CCL). The strong normalization of a, the subcalculus which computes substitutions, may be inferred from the strong normalization of the similar subsystem SUBST of CCL. We present here an independent proof of the termination of several substitution calculi, including a and SUBST.
ONTOGENY OF HEPATIC AND PLASMA METABOLISM OF DELTAMETHRIN IN VITRO: ROLE IN AGE-DEPENDENT ACUTE NEUROTOXICITY

Deltamethrin (DLM) is a relatively potent and widely used pyrethroid insecticide. Inefficient detoxification has been proposed to be the primary reason for the greater sensitivity of immature rats to the acute neurotoxicity of DLM. The objective of this study was to test this hypothesis by characterizing the age dependence of DLM metabolism in vitro, as well as toxic signs and blood levels of the neurotoxic parent compound following administration of 10 mg DLM/kg p.o. in glycerol formal. Metabolism was quantified in vitro by monitoring the disappearance of the parent compound from plasma [via carboxylesterases (CaEs)] and liver microsomes [via CaEs and cytochromes P450 (P450s)] obtained from 10-, 21-, and 40-day-old male Sprague-Dawley rats. Mean (±S.E.) intrinsic clearances (Vmax/Km) in these respective age groups by liver P450s (4.99 ± 0.32, 16.99 ± 1.85, and 38.45 ± 7.03) and by liver CaEs (0.34 ± 0.05, 1.77 ± 0.38, and 2.53 ± 0.19) and plasma CaEs (0.39 ± 0.06, 0.80 ± 0.09, and 2.28 ± 0.56) increased significantly (p ≤ 0.05) with age, because of progressive increases in Vmax. Intrinsic clearance of DLM by plasma CaEs and liver P450s reached adult levels by 40 days, but clearance by liver CaEs did not. Hepatic P450s played the predominant role in DLM biotransformation in young and adult rats. The incidence and severity of neurotoxic effects varied inversely with age. Correspondingly, blood DLM areas under the concentration versus time curve (AUCs) and Cmax values progressively decreased with increasing age. Internal exposure to DLM (blood AUCs) was closely correlated with toxic signs (salivation and tremors). The present study provides evidence that the limited metabolic capacity of immature rats contributes to elevated systemic exposure and ensuing neurotoxic effects of DLM.
Action machines - towards a framework for model composition, exploration and conformance testing based on symbolic computation

We report on a framework for model composition, exploration, and conformance testing based on symbolic execution. The foundations of this framework are given by so-called action machines, a variation of labeled transition systems which communicate over synchronously stepped actions and constraints attached to them. The implementation is based on XRT, an exploration engine for . NET CIL code which supports symbolic computation. The main application is in the area of model-based conformance testing, where our approach addresses practical problems users at Microsoft have in applying model-based testing technology.