Miracle-dz/UniFAR-FTUs huggingface dataset:
Rheumatoid Arthritis with Deficiency Pattern in Traditional Chinese Medicine Shows Correlation with Cold and Hot Patterns in Gene Expression Profiles

In our precious study, the correlation between cold and hot patterns in traditional Chinese medicine (TCM) and gene expression profiles in rheumatoid arthritis (RA) has been explored. Based on TCM theory, deficiency pattern is another key pattern diagnosis among RA patients, which leads to a specific treatment principle in clinical management. Therefore, a further analysis was performed aiming at exploring the characteristic gene expression profile of deficiency pattern and its correlation with cold and hot patterns in RA patients by bioinformatics analysis approach based on gene expression profiles data detected with microarray technology. The TCM deficiency pattern-related genes network comprises 7 significantly, highly connected regions which are mainly involved in protein transcription processes, protein ubiquitination, toll-like receptor activated NF-κB regulated gene transcription and apoptosis, RNA clipping, NF-κB signal, nucleotide metabolism-related apoptosis, and immune response processes. Toll-like receptor activated NF-κB regulated gene transcription and apoptosis pathways are potential specific pathways related to TCM deficiency patterns in RA patients; TCM deficiency pattern is probably related to immune response. Network analysis can be used as a powerful tool for detecting the characteristic mechanism related to specific TCM pattern and the correlations between different patterns.
The Retrospect and Prospect of Facial Attractiveness

Facial attractiveness is important in delivering social affective information.The judgment of facial attractiveness can be influenced by factors such as facial averageness,symmetry,sexual dimorphic feature.In recent years,research of facial attractiveness have been expanded to the dynamic faces.And by adopting functional MRI(fMRI) researchers have discovered that the amygdale,the orbit frontal cortex,the ventral occipital region and other brain regions were activated when subjects are asked to rate the attractive faces.Researchers have explained why attractive faces are preferred from evolutional and cognitive view.Several limitations existed in the previous research's content,material and subjects,which exactly the direction of future research.
The Origin of Cores and Density Profiles of Gaseous Baryonic Structures

We study the origin of cores and density profiles of gaseous baryonic structures in cosmology. By treating the baryons as a viscous gas, we find that both spheres and disks are possible solutions. We find analytically that the density profiles have inner and outer solutions, which in general are different. For disks, we identify a central core with a density profile ρd = constant and an outer profile ρd ~ r-3. For spherical structures, we find the profile ρs ~ r-6. In the presence of a dominating central black hole, we find an inner profile ρ ~ r-3/2. When the mass is dominated by a dark matter component, then the baryonic density profile will depend on the dark matter profile, and we point out how one can use this connection to infer the dark matter profile directly by observing the baryonic density profile.
Role of Electrochemically Activated Solution in Asepsis in Osteoblasts and Chondrocytes in vitro

ABSTRACT Purpose: Implant infections are severe complications in orthopedic surgery. Treatment using antibiotics is often unsuccessful without removing the implant due to biofilm formation. In this context, antiseptics may be a potential option. These solutions have a wide antimicrobial spectrum but often cause damage to the local cell populations. In these cases, electrochemically activated solutions (ECAS) may be an alternative. Methods: Staphylococcus aureus was cultured overnight on polyethylene platelets under different growing conditions (standard-/-different biofilm inducing conditions). The samples were treated with an ECAS (0%–30%) and analyzed with regard to their antimicrobial efficacy and their effect on biofilm structures by determining the living bacterial count and scanning electron microscopy. Osteoblast and chondrocyte cell lines (MG-63, and CAL-78, respectively) were cultured to confluence and treated with an ECAS. Total cell count, metabolic activity using FDA staining, and proliferation using Ki67 staining were analyzed. Results: ECAS showed antimicrobial activity in concentrations <1%. In cases of biofilm formation, bacterial toxicity could be detected at concentrations from 3.75 –7.5%. At these same concentrations, a visible change in biofilm structure was observed. Regarding biocompatibility rates, up to 7.5% (of osteoblasts) and 3.75% (of chondrocytes) had little influence on metabolic activity and proliferation. Conclusion: ECAS provide good antimicrobial efficacy while maintaining high biocompatibility. These results suggest that these solutions may provide promising alternatives in the treatment of implant-associated infections.
Coronary-artery stents.

At present, 90 to 95 percent of percutaneous coronary interventions involve the implantation of a stent, often a drug-eluting stent, though most published data originated in the era of bare-metal stents. This article reviews the indications for and biology of coronary-artery stents, focusing on recent advances in drug-eluting stents.
Scalable FPGA implementation for mixed-norm LMS-LMF adaptive filters

This work proposes a scalable architecture for implementing a mixed-norm LMS-LMF adaptive algorithm using a 16-bit fixed-point arithmetic representation. The hardware scalability allows flexibility in the choice of selecting the order of the filter without redesigning the hardware. The filter also allows flexibility in using application specific sampling frequencies. The hardware architecture was implemented using a Virtex-4 FPGA ML402 board. A 2nd order prototype was tested through both hardware and software simulations. According to the synthesis and the simulation results obtained, the adaptive filter coefficients would converge in less than 17μs with accuracy greater than 95%.
Analyses of skin surface lipid in patients with microbially associated skin disease

The composition of the total skin surface lipid, free fatty acids and fatty acid of triglyceride was used in discriminant analyses to classify patients with severe acne vulgaris (AY), pityriasis versicolor (PV), seborrhoeic dermatitis (SD) and atopic dermatitis (AD). It was not possible to discriminate between the PV and SD patients but alt the lipid groups gave a satisfactory separation between AV, PV + SD and AD patients. A similar separation was obtained when the sex of the patient was studied but not when both sex and disease were taken into account. The results suggest that there are fundamental differences in the composition of skin lipid between patients with microbially associated diseases, but the precise role of the organisms has not been ascertained.
Intelligent joystick for controlling power wheelchair navigation

The aim of this work is to develop a new method for driving assistance for the disabled persons for which a standard joystick is unable to provide their security. Indeed; a new intelligent control algorithm to drive a wheelchair joystick is proposed. This allows the system able to avoid the unforeseen obstacles when a prescribed trajectory of the wheelchair has to be followed by the system driven by a disabled person and consequently ensures his or her safety. The idea is based on the combination of a fuzzy controller with a Vector Field Histogram (VHF) algorithm providing smooth control of the wheelchair that takes into account wheelchair environment submitted to obstacles and random situations. The superiority of the proposed supervised system with respect to standard existing systems is its ability to automatically react in presence of encountered obstacles.
Soy food and isoflavone intake in relation to semen quality parameters among men from an infertility clinic.

BACKGROUND High isoflavone intake has been related to decreased fertility in animal studies, but data in humans are scarce. Thus, we examined the association of soy foods and isoflavones intake with semen quality parameters. METHODS The intake of 15 soy-based foods in the previous 3 months was assessed for 99 male partners of subfertile couples who presented for semen analyses to the Massachusetts General Hospital Fertility Center. Linear and quantile regression were used to determine the association of soy foods and isoflavones intake with semen quality parameters while adjusting for personal characteristics. RESULTS There was an inverse association between soy food intake and sperm concentration that remained significant after accounting for age, abstinence time, body mass index, caffeine and alcohol intake and smoking. In the multivariate-adjusted analyses, men in the highest category of soy food intake had 41 million sperm/ml less than men who did not consume soy foods (95% confidence interval = -74, -8; P, trend = 0.02). Results for individual soy isoflavones were similar to the results for soy foods and were strongest for glycitein, but did not reach statistical significance. The inverse relation between soy food intake and sperm concentration was more pronounced in the high end of the distribution (90th and 75th percentile) and among overweight or obese men. Soy food and soy isoflavone intake were unrelated to sperm motility, sperm morphology or ejaculate volume. CONCLUSIONS These data suggest that higher intake of soy foods and soy isoflavones is associated with lower sperm concentration.
cGMP Signals Modulate cAMP Levels in a Compartment-Specific Manner to Regulate Catecholamine-Dependent Signaling in Cardiac Myocytes

Rationale: cAMP and cGMP are intracellular second messengers involved in heart pathophysiology. cGMP can potentially affect cAMP signals via cGMP-regulated phosphodiesterases (PDEs). Objective: To study the effect of cGMP signals on the local cAMP response to catecholamines in specific subcellular compartments. Methods and Results: We used real-time FRET imaging of living rat ventriculocytes expressing targeted cAMP and cGMP biosensors to detect cyclic nucleotides levels in specific locales. We found that the compartmentalized, but not the global, cAMP response to isoproterenol is profoundly affected by cGMP signals. The effect of cGMP is to increase cAMP levels in the compartment where the protein kinase (PK)A-RI isoforms reside but to decrease cAMP in the compartment where the PKA-RII isoforms reside. These opposing effects are determined by the cGMP-regulated PDEs, namely PDE2 and PDE3, with the local activity of these PDEs being critically important. The cGMP-mediated modulation of cAMP also affects the phosphorylation of PKA targets and myocyte contractility. Conclusions: cGMP signals exert opposing effects on local cAMP levels via different PDEs the activity of which is exerted in spatially distinct subcellular domains. Inhibition of PDE2 selectively abolishes the negative effects of cGMP on cAMP and may have therapeutic potential.
Reliability and Validity of the Korean Version of the Scale to Assessment Unawareness of Mental Disorder (SUMD-K)

Objectives：This study was conducted to evaluate the reliability and the validity of the Korean version of the Scale to Assessment Unawareness of Mental Disorder (SUMD-K). Methods：The subjects were 55 schizophrenic patients between ages of 26 and 58 who were recruited from the psychiatric unit of the university hospital and the out-patient clinic. The SUMD-K and insight scale of PANSS were applied to the patients. Results：The range of inter-rater (Spearman’s rho) of the general items of SUMD-K were . 97-. 98 on the current illness and . 58-. 98 on the past illness. The correlation coefficient between the sum and the general items of the SUMD-K showed high scores. The concurrent validity between SUMD-K and insight item of PANSS was high (scores between .59-.96). However, the reliability and the validity of the attribution items of symptoms showed low scores compared to the current symptoms. Conclusion：The SUMD-K was confirmed in its reliability and validity. It can be a useful clinician-rating scale for evaluating insight in schizophrenic patients as well as patients with other neuropsychiatric conditions. (J Korean Neuropsychiatr Assoc 2006;45(4):307-315)
Overview of Turn Data Management Platform for Digital Advertising

This paper gives an overview of Turn Data Management Platform (DMP). We explain the purpose of this type of platforms, and show how it is positioned in the current digital advertising ecosystem. We also provide a detailed description of the key components in Turn DMP. These components cover the functions of (1) data ingestion and integration, (2) data warehousing and analytics, and (3) real-time data activation. For all components, we discuss the main technical and research challenges, as well as the alternative design choices. One of the main goals of this paper is to highlight the central role that data management is playing in shaping this fast growing multi-billion dollars industry.
Une approche multidimensionnelle de la prédiction de la réussite scolaire

Les variables et les questionnaires qui mesurent la motivation aux etudes (l'autodetermination), les perceptions de soi actuelles (satisfaction de l'etablissement scolaire, estime de soi, interet alloue aux matieres scolaires) et les attitudes a l'egard de l'avenir (valeurs de travail, importance/probabilite, decision scolaire et professionnelle, obstacles relatifs a l'atteinte d'un metier) sont identifiees respectivement et ensemble, dans le but d'evaluer leurs liens avec la reussite scolaire de l'eleve. La saisie de donnees a ete realisee, sous la forme transversale, aupres d'un echantillon d'eleves francais (N=1 681) de differents niveaux du secondaire. On note que l'interet relatif aux matieres scolaires est le meilleur predicteur du succes scolaire des eleves en general. En ce qui concerne les perceptions de soi actuelles, la satisfaction quant a l'etablissement scolaire joue egalement un role dans la reussite scolaire des adolescents de Seconde. Finalement, les attitudes a l'egard de l'avenir (les obstacles et/ou la valeur de travail Liberte-Probabilite) contribuent au modele de la prediction de la reussite scolaire des eleves de B.E. P. et de Terminale, plus proches d'une periode transitionnelle
Constructing Schedules for Time-Critical Data Delivery in Wireless Sensor Networks

Wireless sensor networks for industrial process monitoring and control require highly reliable and timely data delivery. To match performance requirements, specialised schedule based medium access control (MAC) protocols are employed. In order to construct an efficient system, it is necessary to find a schedule that can support the given application requirements in terms of data delivery latency and reliability. Furthermore, additional requirements such as transmission power may have to be taken into account when constructing the schedule. In this article, we show how such schedule can be constructed. We describe methods and tools to collect the data necessary as input for schedule calculation. Moreover, due to the high complexity of schedule calculation, we also introduce a heuristic. We evaluate the proposed methods in a real-world process automation and control application deployed in an oil refinery and further present a long-term experiment in an office environment. Additionally, we discuss a framework for schedule life-cycle management.
Image segmentation through energy minimization based subspace fusion

We present an image segmentation technique that fuses contributions from multiple feature subspaces using an energy minimization approach. For each subspace, we compute a per-pixel quality measure and perform a partitioning through the standard normalized cut algorithm. To fuse the subspaces into a final segmentation, we compute a subspace label for every pixel. The labeling is computed through the graph-cut energy minimization framework proposed by Boycov, Y. , et al. (2001). Finally, we combine the initial subspace segmentation with the subspace labels obtained from the energy minimization to yield the final segmentation. We have implemented the algorithm and provide results for both synthetic and real images.
Entrepreneurship education within the enterprise culture

The enterprise culture is founded on the premise that entrepreneurship is the engine that drives the economy. One aspect of this cultural pervasion is the increase in the numbers of educational institutions teaching entrepreneurship courses. Yet this hegemony of the encouragement of new business start‐up, almost for its own sake, needs to be critically reviewed. One aspect is the enigmatic nature of entrepreneurship itself; what is it, and can it be taught? Another aspect is the very different expectations of those stakeholders promoting entrepreneurship education. Argues that the process of entrepreneurship involves both art and science; consequently our students need more than SME management skills. Graduating enterprise students must be innovative and creative to satisfy the need for entrepreneurial novelty ‐ the art. Yet, paradoxically they also need to be competent and multifunctional managers ‐ the science. Explores both these areas to argue that theory can bridge the art and science. The final section explains briefly how the recent research and practice at Aberdeen University attempts this synthesis. The intended outcome of our educational process are reflective practitioners, fit for an entrepreneurial career.
Primary characterization of a herpesvirus agent associated with Kaposi's sarcomae

Detection of novel DNA sequences in Kaposi's sarcoma (KS) and AIDS-related body cavity-based, non-Hodgkin's lymphomas suggests that these neoplasms are caused by a previously unidentified human herpesvirus. We have characterized this agent using a continuously infected B-lymphocyte cell line derived from an AIDS-related lymphoma and a genomic library made from a KS lesion. In this cell line, the agent has a large episomal genome with an electrophoretic mobility similar to that of 270-kb linear DNA markers during clamped homogeneous electric field gel electrophoresis. A 20.7-kb region of the genome has been completely sequenced, and within this region, 17 partial and complete open reading frames are present; all except one have sequence and positional homology to known gammaherpesvirus genes, including the major capsid protein and thymidine kinase genes. Phylogenetic analyses using both single genes and combined gene sets demonstrated that the agent is a gamma-2 herpesvirus (genus Rhadinovirus) and is the first member of this genus known to infect humans. Evidence for transient viral transmission from infected to uninfected cells is presented, but replication-competent virions have not been identified in infected cell lines. Sera from patients with KS have specific antibodies directed against antigens of infected cell lines, and these antibodies are generally absent in sera from patients with AIDS without KS. These studies define the agent as a new human herpesvirus provisionally assigned the descriptive name KS-associated herpesvirus; its formal designation is likely to be human herpesvirus 8.
Diurnal patterns of urinary steroid excretion in wild chimpanzees

Urinary testosterone and cortisol concentrations were quantified in a large number of samples (>500) collected from wild male chimpanzees (n=11) over the course of 1 year. For both steroids, urinary concentrations were higher and more variable in the morning than in the afternoon. Urinary creatinine levels showed no such diurnal pattern. These patterns are consistent with studies of steroid excretion in humans and gorillas. This study emphasizes the importance of considering time of day as a confounding variable in field studies of primate endocrine function. It also suggests that if a small number of samples are to be used to characterize an individual's basal steroid levels, afternoon samples may be preferable because they show less intra‐individual variability. Am. J. Primatol. 60:161–166, 2003 © 2003 Wiley‐Liss, Inc.
Cell-Link Model for state forecasting of urban road traffic network

Traffic control and guidance is a key issue in intelligent transportation system, and it is based on accurate real time traffic state forecasting. CTM (Cell Transmission Model) can describe traffic flow behavior such as wave and queue. However, original CTM theory has difficulties in describing urban road traffic networks. To address this problem, a novel Cell-Link Model (CLM) is developed in this paper. The CLM establishes road traffic network modeling procedure and puts forward a series of steps to implement network abstraction. The present method is applied to state forecasting of a sample network, and simulation results show that, our method can obtain accurate predict results with high computational efficiency. Therefore, the present method can meet the demand of urban road traffic network state forecasting.
Demo: Scalable and reliable software-defined multicast with BIER and P4

We present an architecture for software-defined multicast that provides scalable and reliable multicast services. We consider the Bit Indexed Explicit Replication (BIER) architecture and Traffic Engineering for BIER (BIER-TE) for packet transport to mitigate scalability concerns of traditional IP multicast. We briefly discuss the advantages of an SDN-based multicast architecture leveraging BIER and discuss implementation options: OpenFlow and the P4 language. We present our prototype based on P4. We implement traditional IP multicast and several BIER variants that may be deployed simultaneously with the prototype. We present various demo scenarios that show the feasibility and the advantages of this architecture.
A cluster analysis of coping among young table tennis players: relationship with stress, recovery, and burnout

this study aimed at examining the ways in which different young table tennis players may combine the use of several coping strategies and at testing whether stress, recovery, and burnout differ across distinctive profiles of coping. The sample consisted of 159 young French table tennis players in intensive training settings who completed self-report questionnaires designed to measure coping, burnout, stress and recovery between 2 to 5 times with delay of one month between each completion, resulting in 693 subjects. The results of hierarchical (Ward's method) and nonhierarchical (k means) cluster analyses indicated that athletes could be classified in four groups according to their use of coping strategies. Results of MANOVA revealed that stress, recovery and burnout significantly differed across the coping profiles. Overall, these findings suggested that research should move from coping strategies to coping profiles in order to provide a deeper understanding of how different athletes cope with stress.
A Search for Pulsars in Quiescent Soft X-Ray Transients. I.

We have carried out a deep search at 1.4 GHz for radio pulsed emission from six soft X-ray transient sources observed during their X-ray quiescent phase. The commonly accepted model for the formation of millisecond radio pulsars predicts the presence of a rapidly rotating, weakly magnetized neutron star in the core of these systems. The sudden drop in accretion rate associated with the end of an X-ray outburst causes the Alfvén surface to move outside the light cylinder, allowing the pulsar emission process to operate. No pulsed signal was detected from the sources in our sample. We discuss several mechanisms that could hamper the detection and suggest that free-free absorption from material ejected from the system by the pulsar radiation pressure could explain our null result.