Miracle-dz/UniFAR-FTUs huggingface dataset:
Data Flow Communication without Interference in Wireless Sensor Networks

Sensor Networks (WSNs) performs by collecting the sensed data from various sensor nodes and store them for future processing. The performance of sensor network application is based on energy efficiency which is maintained wholesome by processing the queries at MAC layer. In this paper it is decided to propose data flow without a little interference using Interference- less Data Flow (IDF), an eminent transmission scheduling technique for real time communication supporting network dynamics and variable workload in wireless sensor networks. The flow scheduling algorithm is used to achieve reduced interference in real time data flow communication. The performance is evaluated using network capacity, average latency , miss ration and drop ratio.
Mouse Models of SCN5A-Related Cardiac Arrhythmias

Mutations of SCN5A gene, which encodes the α-subunit of the voltage-gated Na+ channel NaV1.5, underlie hereditary cardiac arrhythmic syndromes such as the type 3 long QT syndrome, cardiac conduction diseases, the Brugada syndrome, the sick sinus syndrome, a trial standstill, and numerous overlap syndromes. Patch-clamp studies in heterologous expression systems have provided important information to understand the genotype-phenotype relationships of these diseases. However, they could not clarify how SCN5A mutations can be responsible for such a large spectrum of diseases, for the late age of onset or the progressiveness of some of these diseases and for the overlapping syndromes. Genetically modified mice rapidly appeared as promising tools for understanding the pathophysiological mechanisms of cardiac SCN5A-related arrhythmic syndromes and several mouse models have been established. This review presents the results obtained on these models that, for most of them, recapitulate the clinical phenotypes of the patients. This includes two models knocked out for Nav1.5 β1 and β3 auxiliary subunits that are also discussed. Despite their own limitations that we point out, the mouse models still appear as powerful tools to elucidate the pathophysiological mechanisms of SCN5A-related diseases and offer the opportunity to investigate the secondary cellular consequences of SCN5A mutations such as the expression remodeling of other genes. This points out the potential role of these genes in the overall human phenotype. Finally, they constitute useful tools for addressing the role of genetic and environmental modifiers on cardiac electrical activity.
From Intent Reducts for Attribute Implications to Approximate Intent Reducts for Association Rules

Automatic extraction of data dependencies or regularities from historical data is of great importance in practice. Concept lattice could serve as a common framework for such tasks. To deal with two typical kinds of data dependencies, attribute implications and association rules, this paper presents the definitions of intent reducts and approximate intent reducts, as the theoretical foundation for extracting these two kinds of knowledge. Algorithms for calculating them are developed. We also given out the methods for extracting attribute implications and association rules. The results provide a better understanding of attribute implications, association rules, and concept lattices
ThreeFormsof BindingandtheirNeuralSubstrates: Alternativesto TemporalSynchrony

Thispaperpresentsthreedifferentwaysof addressingthebindingproblemin differentbrainareas:genericneocortex, hippocampus, andprefrontalcortex. Noneof theseapproaches involvethepopularmechanismof temporalsynchrony. The first two involve conjuncti ve representationsthat bind by ensuringthat differentneuralunits areactivatedfor differentcombinationsof input features.Specifically, we think the cortex constructslow-orderconjunctionsusing coarse-coded istributed representationsto avoid the combinatorialexplosion usually associatedwith conjuncti ve solutionsto the binding problem. We presenta model that learnstheserepresentationsin a challengingrelational bindingtask,andfurthermoreis capableof considerablegeneralizationto novel inputs.Next, we review theideathat thehippocampusperformsconjuncti vebindingin longtermmemorythroughtheuseof higher-orderconjunctionsthat aremuchmorespecificto particulareventsthanthosein thecortex. Finally, wepresentamodelof averydifferentform of binding that involvesthe phonologicalloop — a mechanismfor maintainingarbitrarysequencesof phonemesin activememory. This phonologicalsystemcanbeusedto bind by continuouslyrepeatingtheto-be-boundinformation (e.g.,“pressleft key for greenX’s,. ”). In total, this work suggeststhat insteadof onesimpleandgenericsolution to the binding problem,the brain hasdevelopeda numberof specializedmechanismsthat build on the strengthsof existingneuralhardwarein differentbrainareas.
Selenium Geochemistry and Health

Selenium (Se) is a naturally occurring metalloid element, which is essential to human and other animal health in trace amounts but is harmful in excess. Of all the elements, Se has one of the narrowest ranges between dietary deficiency ( 400 µg day-1) (1) making it necessary to carefully control intakes by humans and other animals hence the importance of understanding the relationships between environmental exposure and health. Geology exerts a fundamental control on the concentrations of Se in the soils on which we grow the crops and animals that form the human food chain. The Se status of populations, animals and crops vary markedly around the world as a result of different geological conditions. Since diet is the most important source of Se in humans, understanding the biogeochemical controls on the distribution and mobility of environmental Se is key to the assessment of Se-related health risks.
Metrics for Evaluating Coupling and Service Granularity in Service Oriented Architecture

Service Oriented Architecture (SOA) is becoming an increasingly popular architectural style for many organizations due to the promised agility, flexibility benefits. It represents an abstract model of software systems that employ services, which are composed and orchestrated to fulfil a specific domain or business requirement. But, service-oriented systems are often developed in an ad-hoc fashion with little consideration given to good software engineering techniques and practices. Lack of systematic guidelines and processes for the development of service-oriented systems can potentially result in decreased quality of produced software
Key findings towards optimising adalimumab treatment: the concentration-effect curve.

OBJECTIVE To determine a concentration-effect curve of adalimumab in rheumatoid arthritis (RA) patients taking into account the effect of methotrexate (MTX) on concentration and effect and to identify a therapeutic range for adalimumab concentrations. METHODS In a prospective observational cohort study, 221 consecutive patients with RA were treated with 40 mg adalimumab subcutaneously every other week. The relationship between adalimumab trough level and clinical efficacy after 28 weeks of follow-up was determined in a concentration-effect curve. A receiver-operator characteristics (ROC) curve established a therapeutic cut-off concentration. The effect of MTX on adalimumab trough levels was shown by dividing patients that are and are not concomitantly using MTX in the concentration-effect curve and a concentration table. RESULTS Clinical efficacy improved with increasing adalimumab concentration and reached a maximum (mean disease activity score in 28 joints improvement of 2) with levels between 5-8 μg/mL. Levels exceeding 8 μg/mL were illustrated to have no additional beneficial effect on disease activity. The ROC curve showed an area under the curve of 0.695 (95% CI 0.626 to 0.764) for European League Against Rheumatism response and adalimumab levels: good responders versus non-responders and moderate responders. A cut-off of 5 μg/mL had a sensitivity of 91% and a specificity of 43%. Adalimumab levels are influenced by concomitant MTX use: patients on adalimumab monotherapy had a median adalimumab level of 4.1 μg/mL (IQR 1.3-7.7), whereas patients concomitantly taking MTX had a median level of 7.4 μg/mL (IQR 5.3-10.6, p<0.001). CONCLUSIONS Adalimumab trough levels in a range of 5-8 μg/mL are sufficient to reach adequate clinical response. These levels are influenced substantially by concomitant MTX use.
Release Characteristics of Quetiapine Fumarate Extended Release Tablets Under Biorelevant Stress Test Conditions

The aim of the present work was the investigation of robustness and reliability of drug release from 50 to 400 mg quetiapine extended release HPMC matrix tablets towards mechanical stresses of biorelevant intensity. The tests were performed under standard conditions (USP apparatus II) as well as under simulated gastrointestinal stress conditions. Mechanical stresses including pressure and agitation were applied by using the biorelevant dissolution stress test apparatus as it has been introduced recently. Test algorithms already established in previous studies were applied to simulate fasting gastrointestinal conditions. The dissolution experiments demonstrated striking differences in the product performance among standard and stress test conditions as well as dose strengths. In USP apparatus II, dissolution profiles were affected mainly by media pH. The dissolution experiments performed in biorelevant dissolution stress test device demonstrated that stress events of biorelevant intensity provoked accelerated drug release from the tablets.
Learning deep representation of multityped objects and tasks

We introduce a deep multitask architecture to integrate multityped representations of multimodal objects. This multitype exposition is less abstract than the multimodal characterization, but more machine-friendly, and thus is more precise to model. For example, an image can be described by multiple visual views, which can be in the forms of bag-of-words (counts) or color/texture histograms (real-valued). At the same time, the image may have several social tags, which are best described using a sparse binary vector. Our deep model takes as input multiple type-specific features, narrows the cross-modality semantic gaps, learns cross-type correlation, and produces a high-level homogeneous representation. At the same time, the model supports heterogeneously typed tasks. We demonstrate the capacity of the model on two applications: social image retrieval and multiple concept prediction. The deep architecture produces more compact representation, naturally integrates multiviews and multimodalities, exploits better side information, and most importantly, performs competitively against baselines.
A contraction method with implementable proximal regularization for linearly constrained convex programming

The proximal point algorithm (PPA) is classical, and the resulting proximal subproblems may be as difficult as the original problem. In this paper, we show that with appropriate choices of proximal parameters, the application of PPA to the linearly constrained convex programming can result in easy proximal subproblems. In particular, under some practical assumptions on the objective function, these proximal subproblems become implementable in the sense that they all have closed-form solutions or can be efficiently solved up to a high precision. We thus present a contraction method with implementable proximal regularization for linearly constrained convex programming, and its global convergence is proved easily under the analytic framework of contraction type methods.
Histone acetylation and transcriptional regulation in the genome of Saccharomyces cerevisiae

MOTIVATION In eukaryotic genomes, histone acetylation and thereafter departure from the chromatin are essential for gene transcription initiation. Because gene transcription is tightly regulated by transcription factors, there are some speculations on the cooperation of histone acetylation and transcription factor binding. However, systematic statistical analyses of this relationship on a genomic scale have not been reported. RESULTS We apply several statistical methods to explore this relationship on two recent genomic datasets: acetylation levels on 11 histone lysines and binding activities of 203 transcription factors, both in promoter regions across the yeast genome. By canonical correlation analysis, we find that a histone acetylation pattern is correlated with a certain profile of transcription factor binding in the genome. Furthermore, after clustering the genes by their acetylation levels on the 11 histone lysines, the genes within clusters show distinct transcription factor binding profiles, as discovered by principle component analysis. Even after applying fairly stringent statistical measurement, most of these clusters have transcription factors with binding activities significantly deviated from the overall genome. We conclude that in the yeast genome, there is a strong correlation between histone acetylation and transcription factor binding in the promoter regions.
Dietary Supplementation of Female Rats with Elk Velvet Antler Improves Physical and Neurological Development of Offspring

Elk velvet antler (EVA) has a traditional use for promotion of general health. However, evidence of EVA effects at different lifestages is generally lacking. This paper investigated the effects of long-term maternal dietary EVA supplementation on physical, reflexological and neurological development of rat offspring. Female Wistar rats were fed standard chow or chow containing 10% EVA for 90 days prior to mating and throughout pregnancy and lactation. In each dietary group, 56 male and 56 female pups were assessed for physical, neuromotor, and reflexologic development postnatally. Among the examined physical developmental parameters, incisor eruption occurred one day earlier in pups nursing dams receiving EVA. Among neuromotor developmental parameters, duration of supported and unsupported standing was longer for pups nursing EVA supplemented dams. Acquisition of neurological reflex parameters (righting reflex, negative geotaxis, cliff avoidance acoustic startle) occurred earlier in pups nursing dams receiving EVA. Longterm maternal EVA supplementation prior to and during pregnancy and lactation accelerated certain physical, reflexologic, and neuromotor developmental milestones and caused no discernible adverse effects on developing offspring. The potential benefits of maternal EVA supplementation on postnatal development warrants further investigation to determine whether EVA can be endorsed for the promotion of maternal and child health.
On Interruptible Pure Exploration in Multi-Armed Bandits

Interruptible pure exploration in multi-armed bandits (MABs) is a key component of Monte-Carlo tree search algorithms for sequential decision problems. We introduce Discriminative Bucketing (DB), a novel family of strategies for pure exploration in MABs, which allows for adapting recent advances in non-interruptible strategies to the interruptible setting, while guaranteeing exponential-rate performance improvement over time. Our experimental evaluation demonstrates that the corresponding instances of DB favorably compete both with the currently popular strategies UCB1 and Epsilon-Greedy, as well as with the conservative uniform sampling.
Targeted Cytotoxic Therapy Kills Persisting HIV Infected Cells During ART

Antiretroviral therapy (ART) can reduce HIV levels in plasma to undetectable levels, but rather little is known about the effects of ART outside of the peripheral blood regarding persistent virus production in tissue reservoirs. Understanding the dynamics of ART-induced reductions in viral RNA (vRNA) levels throughout the body is important for the development of strategies to eradicate infectious HIV from patients. Essential to a successful eradication therapy is a component capable of killing persisting HIV infected cells during ART. Therefore, we determined the in vivo efficacy of a targeted cytotoxic therapy to kill infected cells that persist despite long-term ART. For this purpose, we first characterized the impact of ART on HIV RNA levels in multiple organs of bone marrow-liver-thymus (BLT) humanized mice and found that antiretroviral drug penetration and activity was sufficient to reduce, but not eliminate, HIV production in each tissue tested. For targeted cytotoxic killing of these persistent vRNA+ cells, we treated BLT mice undergoing ART with an HIV-specific immunotoxin. We found that compared to ART alone, this agent profoundly depleted productively infected cells systemically. These results offer proof-of-concept that targeted cytotoxic therapies can be effective components of HIV eradication strategies.
Asset Substitution in Response to Liquidity Demand and Monetary Policy: Evidence from the Flow of Funds Data in Japan

We empirically investigate asset substitution of economic sectors in response to either liquidity demand or monetary policy shock, using the Japanese flow of funds data. Our interest is in responses of portfolio items of six sectors, financial institutions, central government, public corporations and local government, corporate business, personal, and overseas. It is reasonable to identify both shocks in liquidity demand and monetary policy, using recursive VAR models where the variable ordering is the real GDP, the GDP deflator, the commodity price index, the call rate, the monetary base and each balance-sheet variable. We interpret that structural innovations in the monetary base as liquidity demand shocks and those in the call rate as monetary policy shocks. The responses to either the monetary-policy or liquidity demand shocks are different among sectors, among the transaction items, and between the periods before and after the bubble. Among the sectors, the personal sector exhibits the delayed responses, which are consistent with the limited participation model. The transaction items of the corporate business sector show vivid responses to the shocks. Between the two sub-periods, the stocks held by the financial institutions show the clearly different responses.
Inhibition of the Binding between RGS2 and β-Tubulin Interferes with Spindle Formation and Chromosome Segregation during Mouse Oocyte Maturation In Vitro

RGS2 is a negative regulator of G protein signaling that contains a GTPase-activating domain and a β-tubulin binding region. This study aimed to determine the localization and function of RGS2 during mouse oocyte maturation in vitro. Immunofluorescent staining revealed that RGS2 was widely expressed in the cytoplasm with a greater abundance on both meiotic spindles and first/second polar bodies from the fully-grown germinal vesicle (GV) stage to the MII stages. Co-expression of RGS2 and β-tubulin could also be detected in the spindle and polar body of mouse oocytes at the MI, AI, and MII stages. Inhibition of the binding site between RGS2 and β-tubulin was accomplished by injecting anti-RGS2 antibody into GV-stage oocytes, which could result in oocytes arrest at the MI or AI stage during in vitro maturation, but it did not affect germinal vesicle breakdown. Moreover, injecting anti-RGS2 antibody into oocytes resulted in a significant reduction in the rate of first polar body extrusion and abnormal spindle formation. Additionally, levels of phosphorylated MEK1/2 were significantly reduced in anti-RGS2 antibody injected oocytes compared with control oocytes. These findings suggest that RGS2 might play a critical role in mouse oocyte meiotic maturation by affecting β-tubulin polymerization and chromosome segregation.
Are multiproxy climate reconstructions robust?

64 climate reconstructions, based on regression of temperature fields on multi‐proxies and mutually distinguished by at least one of six standard criteria, cover an entire spread of millennial histories. No single criterion is accountable for the spread, which appears to depend on a complicated interplay of the criteria. The uncertainty is traced back to the fact that regression is applied here in an extrapolative manner, with millennial proxy variations exceeding the standard calibration scale by a factor of 5 and more. Even if linearity still holds for that larger domain the model error propagates in a way that is proportional to both the estimation error and the proxy variations, and is thus extrapolated accordingly. This is particularly critical for the parameter‐loaded multiproxy methods. Without a model error estimate and without techniques to keep it small, it is not clear how these methods can be salvaged to become robust.
Psihonomy - Psychology Investors

Article highlights methods for classifying investors according to their typology, professionalism and courage in investment activity, methods that provide a useful financial tool. Evaluation of investment behaviour in Romania during the transition period ending with the investor profile psihonomic. Psychological profile and classification systems gain popularity there are a lot of sense that in some years, many firms will use it regularly, adjusting investment advisory services to the current needs of customers.
Efficacy of Mycobacterium indicus pranii Immunotherapy as an Adjunct to Chemotherapy for Tuberculosis and Underlying Immune Responses in the Lung

Background The 9-month-long chemotherapy of tuberculosis often results in poor compliance and emergence of drug-resistant strains. So, improved therapeutic strategy is urgently needed. Immunotherapy could be beneficial for the effective management of the disease. Previously we showed the protective efficacy of Mycobacterium indicus pranii (MIP) when given as prophylactic vaccine in animal models of tuberculosis. Methods We sought to investigate whether MIP can be used as an adjunct to the chemotherapy in guinea pig models of tuberculosis. Efficacy of MIP was evaluated when given subcutaneously or by aerosol. Results MIP-therapy as an adjunct to the chemotherapy was found to be effective in accelerating bacterial killing and improving organ pathology. MIP-immunotherapy resulted in higher numbers of activated antigen-presenting cells and lymphocytes in the infected lungs and also modulated the granulomatous response. Early increase in protective Th1 immune response was observed in the immunotherapy group. Following subsequent doses of MIP, decrease in the inflammatory response and increase in the immunosuppressive response was observed, which resulted in the improvement of lung pathology. Conclusion MIP immunotherapy is a valuable adjunct to chemotherapy for tuberculosis. Aerosol route of immunotherapy can play a crucial role for inducing immediate local immune response in the lung.
Mach-Zehnder Bragg interferometer for a Bose-Einstein condensate

We construct a Mach-Zehnder interferometer using Bose-Einstein condensed rubidium atoms and optical Bragg diffraction. In contrast to interferometers based on normal diffraction, where only a small percentage of the atoms contribute to the signal, our Bragg diffraction interferometer uses all the condensate atoms. The condensate coherence properties and high phase-space density result in an interference pattern of nearly 100% contrast. The two arms of the interferometer may be completely separated in space, making it an ideal tool that can be used to detect vortices or other topological condensate phases.
Children and Families in Communities - Theory, Research and Policy

In the past decade the relationship between communities, children and families has inspired a wealth of research and policy initiatives because of a growing belief that the breakdown of families and communities is a significant factor in social problems, including child abuse and juvenile crime. The latest policy initiatives to tackle social problems have therefore targeted communities as well as high risk families. This title amalgamates the latest research on the relationship between children, families and communities and explores policy and practice implications. Material for practitioners and community development workers is also be included. The book is divided in to three parts: 1) theory 2) the effect of community on children, parents and families 3) interventions and policy implications.