Miracle-dz/UniFAR-FTUs huggingface dataset:
Using principles of learning to inform language therapy design for children with specific language impairment.

BACKGROUND Language treatment for children with specific language impairment (SLI) often takes months to achieve moderate results. Interventions often do not incorporate the principles that are known to affect learning in unimpaired learners. AIMS To outline some key findings about learning in typical populations and to suggest a model of how they might be applied to language treatment design as a catalyst for further research and discussion. METHODS & PROCEDURES Three main principles of implicit learning are reviewed: variability, complexity and sleep-dependent consolidation. After explaining these principles, evidence is provided as to how they influence learning tasks in unimpaired learners. Information is reviewed on principles of learning as they apply to impaired populations, current treatment designs are also reviewed that conform to the principles, and ways in which principles of learning might be incorporated into language treatment design are demonstrated. MAIN CONTRIBUTION This paper provides an outline for how theoretical knowledge might be applied to clinical practice in an effort to promote discussion. CONCLUSIONS & IMPLICATIONS Although the authors look forward to more specific details on how the principles of learning relate to impaired populations, there is ample evidence to suggest that these principles should be considered during treatment design.
Application of Sperm Selection Using Hyaluronic Acid Binding in Intracytoplasmic Sperm Injection Cycles: A Sibling Oocyte Study

The purpose of this study was to investigate whether sperm selection by hyaluronic acid (HA) binding could improve fertilization rate and embryo quality in intracytoplasmic sperm injection (ICSI) cycles. Two hundred nineteen oocytes obtained from eighteen women were injected with either HA-bound (n = 107) or conventionally selected spermatozoa (n = 112) in a randomized way. All of the participants were infertile couples who had normal sperm parameters but low fertilization rate in previous in vitro fertilization (IVF) cycle (n = 5) or experienced multiple IVF failures (n = 13). Lower fertilization (75.7% vs 83.0%) and cleavage rate on day 2 (72.9% vs 83.0%) was observed in oocytes injected with HA-bound spermatozoa than the conventional group, but the difference was not significant. Significantly lower cleavage rate was observed on day 3 in HA group (56.0% vs 69.6%, P = 0.038). Blastocyst formation rate and the number of transferred embryos were similar in both groups. In multiple IVF failure patients, significantly reduced fertilization rate (71.8% vs 85.3%, P = 0.046) and cleavage rate on day 2 (70.4% vs 85.3%, P = 0.029) and day 3 (53.5% vs 77.3%, P = 0.002) were noticed in HA group. Five women achieved pregnancy continuing more than 12 weeks after transfer (27.8%). Success of ICSI was not related with the number of embryos fertilized by HA-bound spermatozoa. Application of ICSI by sperm selection using HA binding is not helpful in couples with repeated poor fertilization or implantation despite normal sperm parameters.
[The sentinel lymph node mapping in colon cancer].

BACKGROUND malignant tumors of the colon can metastases along the lymphatic system in a sequential way, which means that there will be a first node to be involved and then from this disease will pass to another node and so gradually. The sentinel lymph node is the first lymph node or group of nodes reached by metastasizing cancer cells from a tumor. OBJECTIVES the present work aims to determine the predictive value of the sentinel lymph node procedure in the staging of non-metastatic colon cancer. PATIENTS AND METHODS in this prospective study joined up only 26 patients with adenocarcinoma of the colon T2-T3, without systemic metastases, and with these criteria for inclusion: a) minimum age: 18 years old; b) staging by total colonoscopy, chest X-ray and CT scan; c) patients classified as ASA 1-3; d) informed consent. Within 20 minutes from the colic resection, the bowel was cut completely along the antimesenteric margin and is performed submucosal injection of vital dye within 5 mm from the lesion at the level of the four cardinal points; then the lymph nodes are placed in formalin and sent to the pathologist. The lymph nodes were subjected to histological examination with haematoxylin-eosin and with the immunohistochemistry technique. RESULTS from January to December 2008 only 26 patients joined up in this prospective study. From the study were excluded the 4 patients with T4 and M1 tumour. Also 7 patients with stenotic lesions were excluded. Patients considered eligible for our study were only 14. The histopathological examination of haematoxylin-eosin revealed: a) in 4 cases were detected mesocolic lymph node metastases; b) in 10 cases were not detected mesocolic lymph node metastases. In cases there were no metastases, the mesocolic sentinel lymph nodes lymph nodes were examined with immunohistochemical technique; in 2 cases were revealed the presence of micrometastases. In one case was identified aberrant lymphatic drainage patterns (skip metastasis); the sentinel lymph node (negative examination wit eaematoxylin-eosin) was studied with immunohistochemical technique that has not revealed the presence of micrometastases. CONCLUSIONS the examination of the sentinel node is feasible with the ex vivo method. Using the immunohistochemical technique we detect micrometastasis in 20% of the cases, not revealed with the classical haematoxylin-eosin examination. The study of sentinel lymph node with multilevel microsections and immunohistochemical techniques allow a better histopathological staging.
Theano-based Large-Scale Visual Recognition with Multiple GPUs

In this report, we describe a Theano-based AlexNet (Krizhevsky et al., 2012) implementation and its naive data parallelism on multiple GPUs. Our performance on 2 GPUs is comparable with the state-of-art Caffe library (Jia et al., 2014) run on 1 GPU. To the best of our knowledge, this is the first open-source Python-based AlexNet implementation to-date.
High-value Recombinant Protein Production in Microalgae

Increasing interest in recombinant protein technologies for human and animal health applications has spotlighted microalgae as a platform with the potential to meet a large impending demand. Here we describe an algae protein expression system and compare the advantages and disadvantages to other platforms currently operating on a commercial level. High-value recombinant proteins that have been produced in microalgae are presented, and strategies for developing production strains with improved commercial properties are discussed.
Scattering of guided waves from complex defects in plates in pipes

Guided ultrasonic waves are successfully employed for rapid screening of plate-like structures and pipelines. Imaging techniques allow to identify and localize areas of the structure with possible defects. However, inverse problem of defect characterization and sizing still represents a considerable challenge. In this paper the efficient FE model is used to simulate the scattering response from various corrosion defects with complex realistic depth and surface profiles. The data is then analyzed in order to determine the defect geometrical parameters (lateral size, depth, etc). The results of analysis are presented and its implications to practical remote defect characterization are discussed.
The pozzolanic reactivities of some New South Wales flyashes and their application to soil stabilization

The reactivities of a number of flyash samples from various electric power stations in New South Wales and their potential value as pozzolanic materials have been investigated. The hydrated calcium aluminates and silicates crystallizing as products of the lime flyash interaction were identified in pastes cured at 35 degrees to 40 degrees centigrade and in compacted mixtures aged under ordinary conditions. The effects of pretreating the flyash with acid or alkali washes, as well as the influence of unburnt carbonaceous material on the formation of the crystalline reaction products have also been determined. The nature of the reaction products formed in lime flyash clay mixtures was investigated in pastes as well as in compacted samples. The conclusions reached were used as a basis for the interpretation of the changes induced in clays by lime flyash additions. Recommendations have been made on the soil types and materials most suitable for lime flyash stabilization (A).
Transcripts from the frameshifted MURF3 gene from Crithidia fasciculata are edited by U insertion at multiple sites.

In trypanosome mitochondria an RNA editing process is operative, which co‐ or post‐transcriptionally alters the nucleotide sequence of transcripts by insertion and/or deletion of U residues at specific sites. To increase our understanding of the mechanism of this process we have compared the nucleotide sequence of the frameshifted mitochondrial MURF3 gene from Crithidia fasciculata to that of a large number of MURF3 cDNAs. We found cDNAs derived from transcripts edited at two different sites in the protein coding sequence: (i) at the frameshift position five extra U residues connect the two reading frames and (ii) at the 5′ terminus 22 inserted Us shift a putative initiator codon out of phase. The collection also contained cDNAs that were derived from non‐edited transcripts. Partially edited sequences were not found, except in one cDNA, which contained an edited frameshift site in combination with a non‐edited 5′ terminus. The analysis further showed that MURF3 transcripts have a 3′‐terminal poly(AU) extension, which varies in sequence. The implications of these results are discussed.
Influence of lithium additions on precipitation and age hardening of 7075 alloy

Abstract The effects of increasing lithium contents on precipitation and hardening mechanisms of 7075 Al–Zn–Mg–Cu alloy have been investigated. It is shown that low (0·7 wt-%) and high (2 wt-%) lithium additions change the precipitation sequence and the age hardening behaviour of the base alloy. In addition, the phases precipitated on aging of the base alloy, i.e. solute rich Guinier–Preston (GP) zone, η′, and η (MgZn2), are completely suppressed. Instead, 7075–0·7Li aged at 120°C reveals the precipitation sequence: vacancy rich GP zone→T′→T ((AI,Zn)49Mg32), and 7075–2Li aged at both 120 and 160°C produces dominant δ′ (Al3Li) and the limited and delayed formation of course T phase precipitates. Correspondingly, the age hardening response which is significant in 7075 alloy is decreased, especially for the 2%Li containing alloy for which a remarkably low age hardening efficiency in both natural aging and artificial aging was obtained. These results are interpreted in terms of the effect of preferential clus.
Intraoperative Red Blood Cell Transfusion During Coronary Artery Bypass Graft Surgery Increases the Risk of Postoperative Low-Output Heart Failure

Background— Hemodilutional anemia during cardiopulmonary bypass (CPB) is associated with increased mortality during coronary artery bypass graft (CABG) surgery. The impact of intraoperative red blood cell (RBC) transfusion to treat anemia during surgery is less understood. We examined the relationship between anemia during CPB, RBC transfusion, and risk of low-output heart failure (LOF). Methods and Results— Data were collected on 8004 isolated CABG patients in northern New England between 1996 and 2004. Patients were excluded if they experienced postoperative bleeding or received ≥3 units of transfused RBCs. LOF was defined as need for intraoperative or postoperative intra-aortic balloon pump, return to CPB, or ≥2 inotropes at 48 hours. Having a lower nadir HCT was also associated with an increased risk of developing LOF (adjusted odds ratio, 0.90; 95% CI, 0.82 to 0.92; P=0.016), and that risk was further increased when patients received RBC transfusion. When adjusted for nadir hematocrit, exposure to RBC transfusion was a significant, independent predictor of LOF (adjusted odds ratio, 1.27; 95% CI, 1.00 to 1.61; P=0.047). Conclusions— In this study, we observed that exposure to both hemodilutional anemia and RBC transfusion during surgery are associated with increased risk of LOF, defined as placement of an intraoperative or postoperative intra-aortic balloon pump, return to CPB after initial separation, or treatment with ≥2 inotropes at 48 hours postoperatively, after CABG. The risk of LOF is greater among patients exposed to intraoperative RBCs versus anemia alone.
Antimicrobial effect of ozonated water, sodium hypochlorite and chlorhexidine gluconate in primary molar root canals

Objective: The aim was to determine the antimicrobial effect of ozonated water, ozonated water with ultrasonication, sodium hypochloride and chlorhexidine (CHX) in human primary root canals contaminated by Enterococcus faecalis (E. faecalis). Materials and Methods: Fifty-eight extracted human primary molar teeth were used. Crowns were cut off using a diamond saw under water-cooling. One hundred roots were obtained and mechanically prepared. The roots were then sterilized by autoclaving in water for 15 min at 121°C. All samples were contaminated with E. faecalis for 24 h and the root canals were randomly divided into five groups (n = 20). Group I: 25 mg/L of Ozonated water (O 3 aq), Group II: 25 mg/L of O 3 aq with ultrasonication, Group III: 2.5% Sodium hypochloride (NaOCl), Group IV: 2% CHX and Group V: Positive control. The canal of each specimen was irrigated for 4 min and positive control was untreated. All root canals were agitated with sterile saline solution. The saline solution was collected from canals with sterile paper points. For each specimen, the paper points were transposed to eppendorf vials containing 2 ml of brain heart infusion. According to bacterial proliferation, the mean values of optical density were achieved by ELέSA (Biotek EL ×800, Absorbance Microplate Reader, ABD) and the data were analyzed. Results: NaOCI, CHX and two types of O 3 aq were found statistically different than positive control group. NaOCI irrigation was found significantly most effective. Conclusions: NaOCl, CHX and O 3 aq applications provide antibacterial effect in vitro conditions in primary root canals.
Evolution of dislocation patterns in a tricrystal model subjected to cyclic loading

When a polycrystalline aggregate is deformed beyond the elastic range, dislocations pile up at grain boundaries and make some patterned structures within the grains. If the external load is reversed, most dislocations at grain boundaries and in the patterned structure are supposed to disappear or change their arrangements, but the details are not yet well known. In this study, we examined such changes in dislocation structures by a crystal plasticity analysis. Models for the polycrystalline aggregates consist of three grains and the generation and degeneration of the geometrically necessary dislocations during cyclic loading are examined in detail. The results show that there are some groups of dislocations that do not dissipate but evolve upon reverse loading.
Switching for functional localization of genetic network programming

Many methods of generating behavior sequences of agents by evolution have been reported. A new evolutionary computation method named genetic network programming (GNP) has also been developed recently along with these trends. The aim of this paper is to build an artificial model to realize functional localization based on GNP considering the fact that the functional localization of the brain is realized in such a way that a different part of the brain corresponds to a different function. GNP has a directed graph structure suitable for realizing functional localization. In this paper, it is especially stated that the evolution of the switching function can be realized for functional localization of GNP using the self-sufficient garbage collector problem.
Dynamic Driver Supply Voltage Scaling for Organic Light Emitting Diode Displays

Organic light emitting diode (OLED) display is a self-illuminating device that is supposed to be more power efficient than liquid crystal display (LCD). However, OLED display panels consume as much power as LCD panels due to total internal reflection. As the power consumption of the OLED panel depends on the pixel colors, most of the earlier power saving methods alter the pixel colors. In practice, such OLED power saving techniques can hardly accommodate photo viewers and movie players. This paper introduces the first OLED power saving technique that dynamically changes the supply voltage of the panel. Reduced supply voltage results in both power saving and decreased pixel luminance, but model-based color correction restores the decreased luminance with minimum color distortion. This technique is similar to dynamic backlight scaling of LCDs but is based on the unique characteristics of the OLED drivers. We provide an online color compensation algorithm using the luminance histogram. Luminance quantization in the histogram also achieves resource minimization. We develop a prototype and demonstrate the proposed OLED dynamic voltage scaling (DVS). Experimental result shows that the proposed OLED DVS saves up to 74.7% of the display power for the still images and up to 35.9% for movie clips.
Impact of plasma protein binding on antimicrobial activity using time-killing curves.

OBJECTIVES Plasma protein binding (PPB) is known to impair the antimicrobial activity of beta-lactams, but its impact on the activity of other classes of antimicrobials such as fluoroquinolones is controversial. This study was undertaken to investigate the effect of PPB on bacterial killing by selected antibiotics and moxifloxacin, which served as a model compound for the class of fluoroquinolones. METHODS Bacterial time-killing curves were employed in the absence and presence of physiological albumin concentrations (40 g/L). Moxifloxacin, ampicillin and oxacillin were investigated. Fosfomycin, a non-protein bound antibiotic was used for comparison. Simulations were carried out by employing concentrations of antibiotics of one-fourth of the minimal inhibitory concentration (MIC), equal to the MIC and four-fold the MIC of one select bacterial strain (Staphylococcus aureus ATCC 29213). To correlate bacterial killing to the extent of PPB, bacterial time-killing curves were plotted using the calculated free and the total drug concentration. RESULTS Bacterial killing by fosfomycin was not affected by the addition of albumin. The antimicrobial activity of oxacillin and ampicillin was reduced in the presence of albumin as expected by the calculation of the free fraction of these antibiotics. Adding albumin to moxifloxacin resulted in a significant decrease in bacterial killing of more than 1 log10 cfu/mL after a period of 8 h when the moxifloxacin concentration was equal to the respective MIC. CONCLUSIONS Our data confirm the view that albumin substantially impairs the antimicrobial activity of antibiotics including moxifloxacin, a member of the class of fluoroquinolones.
Constitutive Equation of Expansion Rock under Humidity Field

The weight and length, width and height of three directions of cuboids’ type calcareous mudstone after infiltrated with water in different period of time were measured by using electronic balance and vernier caliper. The results show that the calcareous mudstone expansion strain is proportional to volume and mass water content. Mchanical properties of calcareous mudstone were studied by uniaxial compression experiments of calcareous mudstone with different water content which carried out by using microcomputer controlled electro-hydraulic servo compression testing machine control system of YAW series. It is concluded from experiment result that calcareous mudstone is brittleness with low water content but when water content reaches saturation, calcareous mudstone presents plastic features. Based on the results above, the constitutive equation of rock considering humidity field is derived which provides important guiding significance to engineering practice.
Investigation of thermo-mechanically induced stress in a PQFP 160 using finite element techniques

The authors use finite element (FE) techniques to illustrate how thermomechanical stresses are built up within a plastic IC package, due to encapsulation. Plane strain is chosen as the most suitable 2D FE model for the thermomechanical stress analysis of plastic packages. The compressive stress on the die is separated into direct and bending components of stress. This is used to show that the molding compound induces over half of the encapsulation stress into the die. An explanation of the compressive stress distribution throughout the die is presented. The encapsulation stress on the die can be eliminated by isolating the die from the package with a side buffer of soft material. <<ETX>>
Delayed Decomposition Approach to Delay-Dependent Stability for Time-Varying Delay Descriptor Systems

This paper studies the problem of stability analysis for descriptor systems with time-varying delay. By developing a delayed decomposition approach, information of the delayed plant states can be taken into full consideration, and new delay-dependent sufficient stability criteria are obtained in terms of linear matrix inequalities (LMIs). Then, based on the Lyapunov method, delay- dependent stability criteria are devised by taking the relationship between terms in the Leibniz-Newton formula into account. Criteria are derived in terms of LMIs, which can be easily solved by using various convex optimization algorithms. It is proved that the newly proposed criteria may introduce less conservatism than some existing ones. Meanwhile, the computational complexity of the presented stability criteria is reduced greatly since fewer decision variables are involved. Numerical examples are included to show that the proposed method is effective and can provide less conservative results.
Design of an efficient miniaturized UHF planar antenna

In this paper the design aspects and the measured results of a novel miniaturized planar antenna are described. The topology of an efficient, miniaturized, resonant slot antenna is presented and its radiation, input impedance, and bandwidth characteristics are investigated. This class of antennas can exhibit simultaneous band selectivity and anti-jam characteristics in addition to possessing a planar structure and low profile, which is easily integrable with other RF and microwave circuits.
The Lifting Model for Reconfiguration

AbstractGiven a pair of start and target configurations, each consisting of n pairwise disjoint disks in the plane, what is the minimum number of moves that suffice for transforming the start configuration into the target configuration? In one move a disk is lifted from the plane and placed back in the plane at another location, without intersecting any other disk. We discuss efficient algorithms for this task and estimate their number of moves under different assumptions on disk radii. We then extend our results for arbitrary disks to systems of pseudodisks, in particular to sets of homothetic copies of a convex object.