Miracle-dz/UniFAR-FTUs huggingface dataset:
Endovascular Treatment of Intracranial Aneurysms With Flow Diverters: A Meta-Analysis

Background and Purpose— Flow diverters are important tools in the treatment of intracranial aneurysms. However, their impact on aneurysmal occlusion rates, morbidity, mortality, and complication rates is not fully examined. Methods— We conducted a systematic review of the literature searching multiple databases for reports on the treatment of intracranial aneurysms with flow-diverter devices. Random effects meta-analysis was used to pool outcomes of aneurysmal occlusion rates at 6 months, and procedure-related morbidity, mortality, and complications across studies. Results— A total of 29 studies were included in this analysis, including 1451 patients with 1654 aneurysms. Aneurysmal complete occlusion rate was 76% (95% confidence interval [CI], 70%–81%). Procedure-related morbidity and mortality were 5% (95% CI, 4%–7%) and 4% (95% CI, 3%–6%), respectively. The rate of postoperative subarachnoid hemorrhage was 3% (95% CI, 2%–4%). Intraparenchymal hemorrhage rate was 3% (95% CI, 2%–4%). Perforator infarction rate was 3% (95% CI, 1%–5%), with significantly lower odds of perforator infarction among patients with anterior circulation aneurysms compared with those with posterior circulation aneurysms (odds ratio, 0.01; 95% CI, 0.00–0.08; P<0.0001). Ischemic stroke rate was 6% (95% CI, 4%–9%), with significantly lower odds of perforator infarction among patients with anterior circulation aneurysms compared with those with posterior circulation aneurysms (odds ratio, 0.15; 95% CI, 0.08–0.27; P<0.0001). Conclusions— This meta-analysis suggests that treatment of intracranial aneurysms with flow-diverter devices is feasible and effective with high complete occlusion rates. However, the risk of procedure-related morbidity and mortality is not negligible. Patients with posterior circulation aneurysms are at higher risk of ischemic stroke, particularly perforator infarction. These findings should be considered when considering the best therapeutic option for intracranial aneurysms.
HtrA2, taming the oncogenic activities of WT1

Wilms' tumour is a paediatric malignancy of the kidneys and is one of the most common solid childhood cancers. The Wilms' tumour 1 protein (WT1) is a transcription factor that can either activate or repress genes involved in growth, apoptosis and differentiation. It is frequently mutated or aberrantly expressed in Wilms' tumour, where the wild type protein would normally act as a tumour suppressor. Several studies, however, have found that wild type WT1 acts as an oncogene in adult tumours, primarily through the inhibition of apoptosis. The expression of WT1 correlates with the aggressiveness of several adult cancers, and its continued expression following treatment is indicative of a poor outcome. We recently found that the treatment of tumour cell lines with cytotoxic drugs leads to the cleavage of WT1 by the serine protease HtrA2. HtrA2 binds to a specific region of WT1, the suppression domain, and then cleaves WT1 at multiple sites. The HtrA2-mediated proteolysis of WT1 leads to its removal from gene promoter regions and changes in gene expression. Cleavage of WT1 by HtrA2 enhances apoptosis. This event is advantageous to the treatment of adult tumours where WT1 acts as an oncogene. However, when WT1 is acting as a tumour suppressor in paediatric malignancies, proteolysis by HtrA2 would be antagonistic to therapy.
Face super-resolution via robust online dictionary learning

In order to solve the problems of face image superresolution, a robust online dictionary learning method based on sparse representation is proposed in this paper. The online dictionary learning algorithms which can be used to train big sample datasets is introduced in the dictionary learning phase to generate better overcomplete dictionaries. Additionally, the classic L2-regularization is replaced by the robust L1regularization in the spare coding procedure. The simulation comparisons and verifications in the experiments prove that the PSNR and SSIM of the proposed method are much higher than some state-of-the-art super-resolution algorithms. The PSNR is 0.72dB higher than [12] Mairal’s online dictionary learning application in super-resolution, while the SSIM is 0.0187 higher. The performance of the proposed algorithm is promising with few artifacts along the edges. Meanwhile, the denoising effect is much better than some classic algorithms while processing noisy face images. Keywordssuper-resolution reconstruction; face; robust; online dictionary learning
Reliable software for unreliable hardware: Embedded code generation aiming at reliability

A compilation technique for reliability-aware software transformations is presented. An instruction-level reliability estimation technique quantifies the effects of hardware-level faults at the instruction-level while considering spatial and temporal vulnerabilities. It bridges the gap between hardware - where faults occur according to our fault model - and software (the abstraction level where we aim to increase reliability). For a given tolerable performance overhead, an optimization algorithm compiles an application software with respect to a tradeoff between performance and reliability. Compared to performance-optimized compilation, our method incurs 60%-80% lower application failures, averaged over various fault injection scenarios and fault rates.
La position initiale dans l'organisation du discours : une exploration en corpus

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. La position initiale dans l’organisation du discours : une exploration en corpus Lydia-Mai Ho-Dac
Large- and very-large-scale motions in channel and boundary-layer flows

Large-scale motions (LSMs; having wavelengths up to 2–3 pipe radii) and very-LSMs (having wavelengths more than 3 pipe radii) have been shown to carry more than half of the kinetic energy and Reynolds shear stress in a fully developed pipe flow. Studies using essentially the same methods of measurement and analysis have been extended to channel and zero-pressure-gradient boundary-layer flows to determine whether large structures appear in these canonical wall flows and how their properties compare with that of the pipe flow. The very large scales, especially those of the boundary layer, are shorter than the corresponding scales in the pipe flow, but otherwise share a common behaviour, suggesting that they arise from similar mechanism(s) aside from the modifying influences of the outer geometries. Spectra of the net force due to the Reynolds shear stress in the channel and boundary layer flows are similar to those in the pipe flow. They show that the very-large-scale and main turbulent motions act to decelerate the flow in the region above the maximum of the Reynolds shear stress.
A study about expectations of the athletes from their coaches resting in Olympics preparation camping Gaziantep

This is a descriptive study, aims to specify the expectations of the athletes from their coaches resting in Olympic Preparation Camp. A total of 120 athletes resting in Olympic Preparation Camp in Gaziantep participated the research including 94 men and 26 women. The expectation scale (ASABO, 2008) was used for collecting the data of this research which was used in scientific study done by Guzel before (7). The scale consist of three sub-dimensions; behavior, coaching model and personality. SPSS 16.0 package was used for statistical analysis of the study and p<0.05 level is accepted as meaningful. Subsidiary statistical methods used in analyzing data (Frequency, percentage, average, Standard deviation). In analyzing of hypothesis, unbiased sample independent sample t-test and One way Anova test were used. Study results revealed that the athletes are mostly 16-18 age range; prefer wrestle and weight lifting as branches and they are graduate from secondary school or high-school. Besides having confidence in athletes, being honest with them and respect to them, not discriminate among them and knowing their personality traits and relationships between each other and also acting consistently and to be open to criticism are highly expected behaviors from the coaches.
Treatment Response of Cystic Echinococcosis to Benzimidazoles: A Systematic Review

Over the past 30 years, benzimidazoles have increasingly been used to treat cystic echinococcosis (CE). The efficacy of benzimidazoles, however, remains unclear. We systematically searched MEDLINE, EMBASE, SIGLE, and CCTR to identify studies on benzimidazole treatment outcome. A large heterogeneity of methods in 23 reports precluded a meta-analysis of published results. Specialist centres were contacted to provide individual patient data. We conducted survival analyses for cyst response defined as inactive (CE4 or CE5 by the ultrasound-based World Health Organisation [WHO] classification scheme) or as disappeared. We collected data from 711 treated patients with 1,308 cysts from six centres (five countries). Analysis was restricted to 1,159 liver and peritoneal cysts. Overall, 1–2 y after initiation of benzimidazole treatment 50%–75% of active C1 cysts were classified as inactive/disappeared compared to 30%–55% of CE2 and CE3 cysts. Further in analyzing the rate of inactivation/disappearance with regard to cyst size, 50%–60% of cysts <6 cm responded to treatment after 1–2 y compared to 25%–50% of cysts >6 cm. However, 25% of cysts reverted to active status within 1.5 to 2 y after having initially responded and multiple relapses were observed; after the second and third treatment 60% of cysts relapsed within 2 y. We estimated that 2 y after treatment initiation 40% of cysts are still active or become active again. The overall efficacy of benzimidazoles has been overstated in the past. There is an urgent need for a pragmatic randomised controlled trial that compares standardized benzimidazole therapy on responsive cyst stages with the other treatment modalities.
An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133

The muscle-specific microRNAs, miR-1 and miR-133, play important roles in muscle growth and differentiation. Here, we show that the MEF2 transcription factor, an essential regulator of muscle development, directly activates transcription of a bicistronic primary transcript encoding miR-1-2 and 133a-1 via an intragenic muscle-specific enhancer located between the miR-1-2 and 133a-1 coding regions. This MEF2-dependent enhancer is activated in the linear heart tube during mouse embryogenesis and thereafter controls transcription throughout the atrial and ventricular chambers of the heart. MEF2 together with MyoD also regulates the miR-1-2/-133a-1 intragenic enhancer in the somite myotomes and in all skeletal muscle fibers during embryogenesis and adulthood. A similar muscle-specific intragenic enhancer controls transcription of the miR-1-1/-133a-2 locus. These findings reveal a common architecture of regulatory elements associated with the miR-1/-133 genes and underscore the central role of MEF2 as a regulator of the transcriptional and posttranscriptional pathways that control cardiac and skeletal muscle development.
AMPNet: Asynchronous Model-Parallel Training for Dynamic Neural Networks

New types of compute hardware in development and entering the market hold the promise of revolutionizing deep learning in a manner as profound as GPUs. However, existing software frameworks and training algorithms for deep learning have yet to evolve to fully leverage the capability of the new wave of silicon. In particular, models that exploit structured input via complex and instance-dependent control flow are difficult to accelerate using existing algorithms and hardware that typically rely on minibatching. We present an asynchronous model-parallel (AMP) training algorithm that is specifically motivated by training on networks of interconnected devices. Through an implementation on multi-core CPUs, we show that AMP training converges to the same accuracy as conventional synchronous training algorithms in a similar number of epochs, but utilizes the available hardware more efficiently, even for small minibatch sizes, resulting in shorter overall training times. Our framework opens the door for scaling up a new class of deep learning models that cannot be efficiently trained today.
Recent Progress in High-Speed Silicon-Based Optical Modulators

The evolution of silicon optical modulators is recalled, from the first effect demonstrations to the characterization of high-performance devices integrated in optical waveguides. Among possibilities to achieve optical modulation in silicon-based materials, the carrier depletion effect has demonstrated good capacities. Carrier depletion in Si and SiGe/Si structures has been theoretically and experimentally investigated. Large phase modulation efficiency, low optical loss, and large cutoff frequency are obtained by considering simultaneously optical and electrical structure performances. Integrated Mach-Zehnder interferometers and resonators are compared to convert phase modulation into intensity modulation. Finally, recent results on high-speed and low-loss silicon optical modulator using an asymmetric Mach-Zehnder interferometer are presented. It is based on a p-doped slit embedded in the intrinsic region of a lateral pin diode integrated in a silicon-on-insulator waveguide. This design allows a good overlap between the optical mode and carrier density variations. An insertion loss of 5 dB has been measured with a -3 dB bandwidth of 15 GHz.
Long‐term depression activates transcription of immediate early transcription factor genes: involvement of serum response factor/Elk‐1

Long‐term depression (LTD) is one of the paradigms used in vivo or ex vivo for studying memory formation. In order to identify genes with potential relevance for memory formation we used mouse organotypic hippocampal slice cultures in which chemical LTD was induced by applications of 3,5‐dihydroxyphenylglycine (DHPG). The induction of chemical LTD was robust, as monitored electrophysiologically. Gene expression analysis after chemical LTD induction was performed using cDNA microarrays containing >7000 probes. The DHPG‐induced expression of immediate early genes (c‐fos, junB, egr1 and nr4a1) was subsequently verified by TaqMan polymerase chain reaction. Bioinformatic analysis suggested a common regulator element [serum response factor (SRF)/Elk‐1 binding sites] within the promoter region of these genes. Indeed, here we could show a DHPG‐dependent binding of SRF at the SRF response element (SRE) site within the promoter region of c‐fos and junB. However, SRF binding to egr1 promoter sites was constitutive. The phosphorylation of the ternary complex factor Elk‐1 and its localization in the nucleus of hippocampal neurones after DHPG treatment was shown by immunofluorescence using a phosphospecific antibody. We suggest that LTD leads to SRF/Elk‐1‐regulated gene expression of immediate early transcription factors, which could in turn promote a second broader wave of gene expression.
Why Work for Extension? An Examination of Job Satisfaction and Motivation in a Statewide Employee Retention Study

Understanding motivation and job satisfaction is important for increasing rates of employee retention within Extension. The purpose of the study reported here was to explore factors positively affecting the motivation of Extension professionals in their careers. An online survey of Extension professionals in Colorado was conducted. Factors such as the opportunity to make a difference in people's lives, variety in daily activities, leave policies, and flexible scheduling were identified as positive motivators, but perceptions of motivators were significantly different between satisfied and dissatisfied employees. Recommendations for improving retention based on what motivates Extension professionals are discussed.
Effects of edaravone on human neutrophil function

Background: Neutrophils play a crucial role in the antibacterial host defence system. Edaravone is used in critically ill patients who are often immuno‐compromised secondary to concomitant disease or immunosuppressive therapy. The aim of the current study was to assess the effect of edaravone, a novel free‐radical scavenger, on several aspects of human neutrophil function using an in vitro system.
Bacterial cyclomodulin Cif blocks the host cell cycle by stabilizing the cyclin‐dependent kinase inhibitors p21waf1 and p27kip1

The cycle inhibiting factor (Cif) is a cyclomodulin produced by enteropathogenic and enterohemorrhagic Escherichia coli. Upon injection into the host cell by the bacterial type III secretion system, Cif inhibits the G2/M transition via sustained inhibition of the mitosis inducer CDK1 independently of the DNA damage response. In this study, we show that Cif induces not only G2, but also G1 cell cycle arrest depending on the stage of cells in the cell cycle during the infection. In various cell lines including differentiated and untransformed enterocytes, the cell cycle arrests are correlated with the accumulation of the cyclin‐dependent kinase inhibitors p21waf1/cip1 and p27kip1. Cif‐induced cyclin‐dependent kinase inhibitor accumulation is independent of the p53 pathway but occurs through inhibition of their proteasome‐mediated degradation. Our results provide a direct link between the mode of action of Cif and the host cell cycle control.
The Use of Transdermal Buprenorphine in Complex Regional Pain Syndrome: A Report of Two Cases

ABSTRACT Management of complex regional pain syndrome (CRPS) can be challenging. Various pharmacological approaches have produced mixed results. Buprenorphine activates mu-opioid receptors and antagonizes kappa and delta receptors, acts at N-methyl-d-aspartate (NMDA) receptor, and is an orphan-related ligand-1 receptor agonist. It is available in transdermal patches that last for up to 7 days. This report describes two patients with refractory CRPS who were treated with transdermal buprenorphine. The patients experienced approximately 50% reduction in pain intensity scores. Application site rash that occurred was managed with topical steroid spray used before applying the patch.
Process variability considerations in the design of an eSRAM

Process variation constitutes a serious hindrance to the performance of SRAMs, since memories require bigger design margins for their proper operations. In this paper, we propose a new dummy bit line driver structure and its statistical sizing method to reduce the sensitivity of the memory with respect to process variations, while improving the read timing margin. The dummy bit line driver is an essential component in a self-timed memory during a read operation. It triggers the sense amplifier at the appropriate time when bit line is discharged. We considered a 256 kb SRAM in a 90 nm technology node.
Multiple-Locus Variable-Number Tandem-Repeat Analysis for Longitudinal Survey of Sources of Pseudomonas aeruginosa Infection in Cystic Fibrosis Patients

ABSTRACT In order to identify the source of infection by Pseudomonas aeruginosa in patients with cystic fibrosis (CF), systematic genotyping of isolates is necessary. Multiple-locus variable-number tandem-repeat (VNTR) analysis (MLVA) was used to survey the sources of P. aeruginosa infections in a French (Paris, France) pediatric CF center. Between January 2004 and December 2006, 108 patients ages 2 to 21 years who were regularly monitored at the center provided sputum for culture. P. aeruginosa was detected in 46 children, 17 of whom had primary colonization. A total of 163 isolates were recovered. MLVA was improved from a previously published method by the addition of new, informative, and easily typeable markers. Upon genotyping with 15 VNTRs, a total of 39 lineages composed of indistinguishable or closely related isolates, were observed. One of them corresponds to “clone C,” which is widely distributed in Europe, and another corresponds to reference strain PA14. Six patients were colonized with two different strains, and the remaining 40 patients were colonized with a single strain. Strains from seven lineages were shared by at least two and up to four patients among a total of 20 patients. The study demonstrates that MLVA is an efficient, easy, and rapid molecular method for epidemiological surveillance for P. aeruginosa infection. The resulting data and strain genetic profiles can be queried on http://bacterial-genotyping.igmors. u-psud.fr .
Anxiety sensitivity, fear of pain and pain-related disability in children and adolescents with chronic pain.

BACKGROUND Converging lines of evidence suggest that anxiety sensitivity and fear of pain may be important vulnerability factors in the development of avoidance behaviours and disability in adults with chronic pain. However, these factors have not been evaluated in children with chronic pain. OBJECTIVES To examine the relationships among anxiety sensitivity, fear of pain and pain-related disability in children and adolescents with chronic pain. METHODS An interview and five questionnaires (Childhood Anxiety Sensitivity Index, Pain Anxiety Symptoms Scale, Functional Disability Inventory, Multidimensional Anxiety Scale for Children, and Reynolds Child or Adolescent Depression Scale) were administered to 21 children and adolescents eight to 17 years of age (mean +/- SD 14.24+/-2.21 years) who continued to experience pain an average of three years after discharge from a specialized pain clinic for children. RESULTS Anxiety sensitivity accounted for 38.6% of the variance in fear of pain (F[1,20]=11.30; P=0.003) and fear of pain accounted for 39.9% of the variance in pain-related disability (F[1,20]=11.95; P=0.003), but anxiety sensitivity was not significantly related to pain disability (R2=0.09; P>0.05). CONCLUSIONS These findings indicate that children with high levels of anxiety sensitivity had a higher fear of pain, which, in turn, was linked to increased pain disability. The results of this study suggest that anxiety sensitivity and fear of pain may play important and distinct roles in the processes that maintain chronic pain and pain-related disability in children.
The Role of Repetition in the Practice Sessions of Artist Teachers and Their Students

While it is known that repetition is a common strategy employed in the practice sessions of all musicians, very little is known about the extent to which musicians of high proficiency levels use repetition in their practice. The purpose of this study was to describe the role of repetition in the practice activities of musicians representing four levels of high musical proficiency. Specifically, this study examined in detail the process used to isolate, remediate, and recontextualize music in the subjects? practice sessions, and examined the number of consecutive performances of passages selected for repeated practice. Nineteen subjects were videotaped on two separate occasions practicing for a minimum of one hour. One extended segment during which each subject practiced a single work was selected for detailed analysis. Data were recorded graphically. The total number and mean durations of practice frames and performance trials per frame were then calculated. Based on 14 hours 54 minutes of practice time, 800 practice frames, and 8,527 performance trials, the results illustrate the extensive use of repetition in advanced performers? practice. The mean number of performance trials devoted to each target passage was 10.7, the mean duration of all performance trials was 6.3 seconds, and the mean duration of each practice frame was 1 minute 7 seconds.