Miracle-dz/UniFAR-FTUs huggingface dataset:
Stretchable interconnects for smart integration of sensors in wearable and robotic applications

Stretchable electronic systems are needed in realising a wide range of applications, such as wearable healthcare monitoring where stretching movements are present. Current electronics and sensors are rigid and non-stretchable. However, after integrating with stretchable interconnects, the overall system is able to withstand a certain degree of bending, stretching and twisting. The presence of stretchable interconnects bridges rigid sensors to stretchable sensing networks. In this thesis, stretchable interconnects focusing on the conductive polymer Poly (3,4-ethylenedioxythiophene): poly (4-styrenesulfonate) (PEDOT:PSS) , the composite and the metallic-polyimide (PI) are presented. Three type of stretchable interconnects were developed including gold (Au) -PEDOT:PSS hybrid film interconnects, Graphite-PEDOT:PSS composite interconnects and Au-PI dual-layered interconnects. The Au-PEDOT:PSS hybrid interconnects’ stretchability can reach 72%. The composite exhibits a stretchability of 80% but with an extremely high variation in resistance (100000%). The Au-PI interconnects that have a serpentine shape with the arc degree of 260° reveal the highest stretchability, up to 101%, and its resistance variation remains within 0.2%. Further, the encapsulation effect, cyclic stretching, and contact pad’s influence, are also investigated. To demonstrate the application of developed stretchable interconnects, this thesis also presents the optimised interconnects integrated with the electrochemical pH sensor and CNT-based strain sensor. The integrated stretchable system with electrochemical pH sensor is able to wirelessly monitor the sweat pH. The whole system can withstand up to 53% strain and more than 500 cycles at 30% strain. For the CNT-based strain sensor, the sensor is integrated on the pneumatically actuated soft robotic finger to monitor the bending radius (23 mm) of the finger. In this way, the movement of the soft robotic finger can be controlled. These two examples of sensor’s integration with stretchable interconnects successfully demonstrate the concept of stretchable sensing network. Further work will focus on realising a higher density sensing and higher multifunctional sensing stretchable system seamlessly integrated with cloth fibres.
Genetic evidence linking lung cancer and COPD: a new perspective

Epidemiological studies indicate that tobacco smoke exposure accounts for nearly 90% of cases of chronic obstructive pulmonary disease (COPD) and lung cancer. However, genetic factors may explain why 10%–30% of smokers develop these complications. This perspective reviews the evidence suggesting that COPD is closely linked to susceptibility to lung cancer and outlines the potential relevance of this observation. Epidemiological studies show that COPD is the single most important risk factor for lung cancer among smokers and predates lung cancer in up to 80% of cases. Genome-wide association studies of lung cancer, lung function, and COPD have identified a number of overlapping “susceptibility” loci. With stringent phenotyping, it has recently been shown that several of these overlapping loci are independently associated with both COPD and lung cancer. These loci implicate genes underlying pulmonary inflammation and apoptotic processes mediated by the bronchial epithelium, and link COPD with lung cancer at a molecular genetic level. It is currently possible to derive risk models for lung cancer that incorporate lung cancer-specific genetic variants, recently identified “COPD-related” genetic variants, and clinical variables. Early studies suggest that single nucleotide polymorphism-based risk stratification of smokers might help better target novel prevention and early diagnostic strategies in lung cancer.
Non-linear Modelling of a Production Process by Hybrid Bayesian Networks

This paper shows how non-linear functions can be approximated by hybrid Bayesian networks. The basic idea is to make a piecewise linear approximation with several base points. This approach is applied to an engineering domain and the accuracy is compared to Gibbs sampling. Great accuracy is shown even at non-continuous functions. Due to the general underlying principle, it is possible to adapt this type of network to other domains.
The population genomic signature of environmental association and gene flow in an ecologically divergent tree species Metrosideros polymorpha (Myrtaceae)

Genomewide markers enable us to study genetic differentiation within a species and the factors underlying it at a much higher resolution than before, which advances our understanding of adaptation in organisms. We investigated genomic divergence in Metrosideros polymorpha, a woody species that occupies a wide range of ecological habitats across the Hawaiian Islands and shows remarkable phenotypic variation. Using 1659 single nucleotide polymorphism (SNP) markers annotated with the genome assembly, we examined the population genetic structure and demographic history of nine populations across five elevations and two ages of substrates on Mauna Loa, the island of Hawaii. The nine populations were differentiated into two genetic clusters distributed on the lower and higher elevations and were largely admixed on the middle elevation. Demographic modelling revealed that the two genetic clusters have been maintained in the face of gene flow, and the effective population size of the high‐altitude cluster was much smaller. A FST‐based outlier search among the 1659 SNPs revealed that 34 SNPs (2.05%) were likely to be under divergent selection and the allele frequencies of 21 of them were associated with environmental changes along elevations, such as temperature and precipitation. This study shows a genomic mosaic of M. polymorpha, in which contrasting divergence patterns were found. While most genomic polymorphisms were shared among populations, a small fraction of the genome was significantly differentiated between populations in diverse environments and could be responsible for the dramatic adaptation to a wide range of environments.
Lipid-rich and Clear Cell Neuroendocrine Tumors (“Carcinoids”) of the Appendix: Potential Confusion With Goblet Cell Carcinoid

The so-called clear cell change has been described in neuroendocrine tumors at several locations. Those associated with von Hippel Lindau disease are pathognomonically “clear” and the cytoplasmic appearance has been ascribed to intracytoplasmic lipid. However, lipid has not been demonstrated in all cases of clear cell carcinoid tumors. Such variants have not been described in carcinoid tumors of the appendix and cases with a prominent proportion of clear or more correctly, lipid-rich cytoplasm may bear a superficial resemblance to goblet cell carcinoid and/or signet ring adenocarcinoma. Seven cases, in 5 females and 2 males ranging in age from 22 to 65 years, were noted to have a population of lipid-rich and vacuolated clear cells accounting for 25% or more of the tumor population. The carcinoid tumors were incidental in all cases with 4 of patients presenting with appendicitis, 2 with concomitant mucinous cystadenocarcinomas of the appendix and 1 with an adenocarcinoma of the ascending colon. Morphologically, the tumors had a nested and trabecular pattern and were composed of an admixture of microvesicular and clear lipid-rich cells. There were no mitoses, areas of necrosis of lymphovascular invasion and all cases extended to the mesoappendix. All cases were positive for synaptophysin, chromogranin, and serotonin but negative for inhibin. Three cases were examined ultrastructurally, and showed the presence of intracytoplasmic lipid and neurosecretory granules. None of the patients have shown evidence of recurrent disease. The importance of recognizing this variant of carcinoid tumor in the appendix is to avoid confusion with goblet cell carcinoid tumors with or without a signet ring adenocarcinoma. The presence of multi-vacuolated, foamy and clear cells, some resembling signet ring or goblet cells, in otherwise classic carcinoid tumors is rare but should be considered in this context in the appendix.
Code-aided turbo synchronisation using irregular low-density parity check codes

An efficient scheme for iterative carrier recovery by using irregular low-density parity check (LDPC) codes is proposed at low signal-to-noise ratio (SNR) conditions. Owing to the significant effect of decoding extrinsic information on the carrier estimation algorithms, deficiency of extrinsic information from decoding caused by large residual frequency or phase offsets in initial iterations will result in incorrect parameter estimation and compensation, which would fail to converge toward low BER in decoding process. Irregular LDPC codes have inherence unequal error protection (UEP) capabilities wherein the high-degree nodes tend to correct their value more quickly than low-degree nodes. The more reliable information, which is provided by the high-degree nodes of irregular LDPC code in initial iterations, can be used to offer more reliable soft information for carrier synchronisation even in poor channel conditions, which leads to improvement of the carrier parameter estimation performance. The simulation results indicate that the more reliable information from irregular LDPC codes can cope with large frequency, phase uncertainty region and speed up the convergence properties for iterative synchronisers when comparing with regular LDPC codes with same parameters.
Logical and Algebraic Views of a Knot Fold of a Regular Heptagon

Making a knot on a rectangular origami or more generally on a tape of a finite length gives rise to a regular polygon. We present an automated algebraic proof that making two knots leads to a regular heptagon. Knot fold is regarded as a double fold operation coupled with Huzita’s fold operations. We specify the construction by describing the geometrical constraints on the fold lines to be used for the construction of a knot. The algebraic interpretation of the logical formulas allows us to solve the problem of how to find the fold operations, i.e. to find concrete fold lines. The logical and algebraic framework incorporated in a system called Eos (e-origami system) is used to simulate the knot construction as well as to prove the correctness of the construction based on algebraic proof methods.
Temperature increasing in titanium implants using a high-intensity diode laser for peri-implantitis decontamination

Peri-implantitis is a destructive inflammatory process that affects the tissues that provide support to the dental implant, the bone and gingiva, and can lead to the loss of the implant. Among the treatments of this disease, the irradiation of the contaminated surface with high intensity lasers is considered a promising alternative; Thus, irradiation parameters must be correctly adjusted in order to promote an efficient and safe treatment. This study investigated the temperature changes at the implant-bone interface during simulated implant surface decontamination using an 808nm diode laser. Dental implants were inserted in bovine bone, in which an artificial periimplant bone defect was made. Access holes of 0.5mm diameter were drilled to allow the positioning of four Ktype thermocouples in different regions: T0 Implant-bone interface, T1 inside the implant, T2 In the bone defect, T3 In the apex of the implant. For laser irradiation, an optical fiber was used at a distance of 0.5mm from the implant surface, and the mean output power varied between 0.5 to 3.0W on both pulsed (PW) and continuous (CW) wave modes. Irradiations were performed by 60s, and the temperature rises were registered for a period of 180s. It was observed that the critical threshold of 47ºC was exceeded at T0, T1 e T2 thermocouples when irradiations were performed at 1.0W; for T3 thermocouple, the threshold was exceeded at 3.0W CW mode. For PW mode, the thermocouples T0, T1, T2 had the threshold exceeded at the power of 1,0W and for T3 the threshold was exceeded at 3.0W. Decontamination of implant surfaces using the diode laser did not excessively heat the implant-bone interface within the mean output power ranging from 0.5 to 1.0W; however, the temperature rise is critical when using the mean power of 0.5W CW and 1.0W PW. Thus, using the PW mode up to the power of 1W seems to be a promising parameter for a safe clinical application.
Effects of zinc-L-carnosine and vitamin E on aspirin-induced gastroduodenal injury in dogs.

BACKGROUND Nonsteroidal anti-inflammatory drugs frequently cause gastrointestinal (GI) injury. Zinc-L-carnosine has antioxidant, anti-inflammatory, mucosal protective, and healing properties in rodent models and in some human studies of GI injury. HYPOTHESIS The combination of zinc-L-carnosine and vitamin E attenuates aspirin-induced gastroduodenal mucosal injury. ANIMALS Eighteen healthy random-source Foxhound dogs. METHODS In this randomized, double-blinded, placebo-controlled study dogs were treated with placebo (n = 6; 0X group), 30 mg/30 IU (n = 6; 1X group), or 60 mg/60 IU (n = 6; 2X group) zinc-L-carnosine/vitamin E orally every 12 hours for 35 days. Between Day 7 and 35, GI mucosal lesions were induced with aspirin (25 mg/kg p.o. q8h). Mucosal injury lesions (hemorrhage, erosion, and ulcer) were assessed by gastroduodenoscopy on Days 14, 21, and 35 with a 12-point scoring scale. RESULTS At baseline (Day -1) gastroscopy scores were not significantly different between groups (mean ± SD: 0X, 4.4 ± 0.8; group 1X, 4.4 ± 0.6; group 2X, 4.2 ± 0.3; P= .55). Gastroscopy scores increased significantly in all groups between Day -1 and Days 14, 21, and 35 (P < .0001). On Day 35, gastroscopy scores were 29.2 ± 5.2 (0X), 27.3 ± 3.7 (1X), and 28.6 ± 3.3 (2X). Mean gastroscopy scores were not significantly different among treatment groups on any of the days (P = .61). CONCLUSIONS AND CLINICAL IMPORTANCE Administration of the combination of zinc-L-carnosine and vitamin E at 1X or 2X dosing did not attenuate aspirin-induced gastroduodenal mucosal injury.
Amortizing Software Queue Overhead for Pipelined Inter-Thread Communication

Future chip multiprocessors are expected to contain multiple ondie processing cores. Increased memory system contention and wire delays will result in high inter-core latencies in these processors. Thus, parallelizing applications to efficiently execute on multiple contexts is key to achieving continued performance improvements. Recently proposed pipelined multithreading (PMT) techniques have shown significant promise for both manual and automatic parallelization. They tolerate increasing inter-thread communication delays by enforcing acyclic dependences amongst communicating threads and pipelining communication. However, lack of efficient communication support for such programs hinders related language and compiler research. While researchers have proposed dedicated interconnects and storage for inter-core communication, such mechanisms are not cost-effective, consume extra power, demand chip redesign effort, and necessitate complex operating system modifications. Software impelementations of shared memory queues avoid these problems. But, they tend to have heavy overhead per communication operation, causing them to negate parallelization benefits and worse still, to perform slower than the original single-threaded codes. In this paper, we present a simple compiler analysis to coalesce synchronization and queue pointer updates for select communication operations, to minimize the intra-thread overhead of software queue implementations. A preliminary comparison of static schedule heights shows a considerable performance improvement over existing software queue implementations.
The global prevalence of common mental disorders: a systematic review and meta-analysis 1980-2013.

BACKGROUND Since the introduction of specified diagnostic criteria for mental disorders in the 1970s, there has been a rapid expansion in the number of large-scale mental health surveys providing population estimates of the combined prevalence of common mental disorders (most commonly involving mood, anxiety and substance use disorders). In this study we undertake a systematic review and meta-analysis of this literature. METHODS We applied an optimized search strategy across the Medline, PsycINFO, EMBASE and PubMed databases, supplemented by hand searching to identify relevant surveys. We identified 174 surveys across 63 countries providing period prevalence estimates (155 surveys) and lifetime prevalence estimates (85 surveys). Random effects meta-analysis was undertaken on logit-transformed prevalence rates to calculate pooled prevalence estimates, stratified according to methodological and substantive groupings. RESULTS Pooling across all studies, approximately 1 in 5 respondents (17.6%, 95% confidence interval:16.3-18.9%) were identified as meeting criteria for a common mental disorder during the 12-months preceding assessment; 29.2% (25.9-32.6%) of respondents were identified as having experienced a common mental disorder at some time during their lifetimes. A consistent gender effect in the prevalence of common mental disorder was evident; women having higher rates of mood (7.3%:4.0%) and anxiety (8.7%:4.3%) disorders during the previous 12 months and men having higher rates of substance use disorders (2.0%:7.5%), with a similar pattern for lifetime prevalence. There was also evidence of consistent regional variation in the prevalence of common mental disorder. Countries within North and South East Asia in particular displayed consistently lower one-year and lifetime prevalence estimates than other regions. One-year prevalence rates were also low among Sub-Saharan-Africa, whereas English speaking counties returned the highest lifetime prevalence estimates. CONCLUSIONS Despite a substantial degree of inter-survey heterogeneity in the meta-analysis, the findings confirm that common mental disorders are highly prevalent globally, affecting people across all regions of the world. This research provides an important resource for modelling population needs based on global regional estimates of mental disorder. The reasons for regional variation in mental disorder require further investigation.
Image Splicing Detection Using Inherent Lens Radial Distortion

Image splicing is a common form of image forgery. Such alterations may leave no visual clues of tampering. In recent works camera characteristics consistency across the image has been used to establish the authenticity and integrity of digital images. Such constant camera characteristic properties are inherent from camera manufacturing processes and are unique. The majority of digital cameras are equipped with spherical lens and this introduces radial distortions on images. This aberration is often disturbed and fails to be consistent across the image, when an image is spliced. This paper describes the detection of splicing operation on images by estimating radial distortion from different portions of the image using line-based calibration. For the first time, the detection of image splicing through the verification of consistency of lens radial distortion has been explored in this paper. The conducted experiments demonstrate the efficacy of our proposed approach for the detection of image splicing on both synthetic and real images.
Real-Time Isosurface Extraction Using the GPU Programmable Geometry Pipeline

Figure 1. We show the result of extracting a series of highly detailed isosurfaces at interactive rates. Our system implements a hybrid cubes-tetrahedra method, which leverages the strengths of each as applicable to the unique architecture of the GPU. The left pair of images (wireframe and shaded, using a base cube grid of 64) show only an extracted isosurface, while the right pair displays an alternate isosurface overlayed with a volume rendering.
Fabrication of micro/nano optical fiber by mechano-electrospinning

We study a novel fabrication method of micro/nano optical fiber by mechano-electrospinning (MES) direct-written technology. MES process is able to precisely manipulate the position and diameter of the electro-spun micro/nano fiber by adjusting the mechanical drawing force, which through changing the speed of motion stage (substrate). By adjusting the substrate speed, the nozzle-to-substrate distance and the applied voltage, the poly(methyl methacrylate) (PMMA) micro/nano optical fibers (MNOF) with controlled diameter are obtained and the tapered MNOF are fabricated by continuously changing the substrate speed. The transmission characteristics of PMMA micro/nano fiber is experimentally demonstrated, and a PMMA micro/nano fiber based refractive index sensor is designed. Our works shows the new fabrication method of MNOF by MES has the potential in the field of light mode conversion, optical waveguide coupling, refractive index detection and new micro/nano optical fiber components.
Aspects of awareness in patients with Alzheimer's disease

ABSTRACT Background: The purpose of the present study was to gain insight into Alzheimer's disease (AD) patients’ perception of the world through the study of a few aspects of awareness. The aspects in focus of the study were disease awareness, metacognition, managing of everyday life, and as a complement, the agreement (calibration) between patients and their spouses on the studied aspects was considered. Method: A mixed-method evaluation design was used involving 15 AD patients, their spouses, and 15 elderly healthy control subjects. The study comprised both a semistructured interview (AD patients and spouse) and a neuropsychological assessment (AD patients and control subjects). Results: The patients were aware of their disease and able to report on their illness. Despite this awareness, they were unable to realize and manage the practical and cognitive implications of their impairment. The results also indicate that patients and spouses were not well calibrated regarding thoughts about the disease and problems in handling the cognitive deterioration. Conclusions: The findings of our study have relevance to patients’ well being and how they manage everyday life. An open dialogue on these issues between spouses and in the care for AD patients would hopefully enhance quality of life for all parties involved.
Design of a narrow span nozzle: a round jet impacting a disk engraved with radial grooves

The present work investigates the impact of a turbulent round jet on a motionless disk that is engraved along its circumference by a number N of radial grooves. The grooves are used to split the liquid sheet into multiple jets. According to the incoming flow and to the geometry of the grooves, the number of the generated jets n correspond to: 2 N jets, N* jets (mixed zone), N jets and N/2 jets. The emitted droplets sizes are characterized.