Miracle-dz/UniFAR-FTUs huggingface dataset:
[Effects of self-foot reflexology on stress, fatigue and blood circulation in premenopausal middle-aged women].

PURPOSE This study was to examine the effects of self-foot reflexology on stress, fatigue and blood circulation in premenopausal middle-aged women. METHODS A quasi-experimental nonequivalent control group, pretest-posttest design was used. Participants were 59 premenopausal, middle-aged women in their 40s and 60s living in G city: 30 in the experiment group and 29 in the control group. Data were collected from May to August 2008. Self-foot reflexology was performed three times a week for 6 weeks for 40 min at each session. RESULTS The results showed that self-foot reflexology was effective in reducing perceived stress and fatigue and helped blood circulation in premenopausal middle-aged women. CONCLUSION Self-foot reflexology may be an effective nursing intervention in reducing perceived stress and fatigue and in improving blood circulation.
Prediction for Common Disease using ID3 Algorithm in Mobile Phone and Television

The data mining has become a unique tool in analyzing data from different perspective and converting it into useful and meaningful information. Now we have a lot of known diseases and unknown diseases around the world. The healthcare has big challenge to predict the kind of disease and the solution for that disease. In India illiteracy rate is high, so that most of the people are scared about these diseases become of thesis ignorance. Hence they may take wrong decision regarding the disease that they have been affected problem. Considering this serious issue we have used data mining as a tool to overcome this issue. We have already created the prediction for common disease [17]. And we are in the process implementing of mobile phone and television because all category people can used easily find and predicted what kind of disease through television and mobile phones.
Interferon-Induced Transmembrane Protein 3 Inhibits Hantaan Virus Infection, and Its Single Nucleotide Polymorphism rs12252 Influences the Severity of Hemorrhagic Fever with Renal Syndrome

Hantaan virus (HTNV) causes hemorrhagic fever with renal syndrome (HFRS). Previous studies have identified interferon-induced transmembrane proteins (IFITMs) as an interferon-stimulated gene family. However, the role of IFITMs in HTNV infection is unclear. In this study, we observed that IFITM3 single nucleotide polymorphisms (SNP) rs12252 C allele and CC genotype associated with the disease severity and HTNV load in the plasma of HFRS patients. In vitro experiments showed that the truncated protein produced by the rs12252 C allele exhibited an impaired anti-HTNV activity. We also proved that IFITM3 was able to inhibit HTNV infection in both HUVEC and A549 cells by overexpression and RNAi assays, likely via a mechanism of inhibiting virus entry demonstrated by binding and entry assay. Localization of IFITM3 in late endosomes was also observed. In addition, we demonstrated that the transcription of IFITM3 is negatively regulated by an lncRNA negative regulator of interferon response (NRIR). Taken together, we conclude that IFITM3, negatively regulated by NRIR, inhibits HTNV infection, and its SNP rs12252 correlates with the plasma HTNV load and the disease severity of patients with HFRS.
Characterizing a neurodegenerative syndrome: primary progressive apraxia of speech

Apraxia of speech is a disorder of speech motor planning and/or programming that is distinguishable from aphasia and dysarthria. It most commonly results from vascular insults but can occur in degenerative diseases where it has typically been subsumed under aphasia, or it occurs in the context of more widespread neurodegeneration. The aim of this study was to determine whether apraxia of speech can present as an isolated sign of neurodegenerative disease. Between July 2010 and July 2011, 37 subjects with a neurodegenerative speech and language disorder were prospectively recruited and underwent detailed speech and language, neurological, neuropsychological and neuroimaging testing. The neuroimaging battery included 3.0 tesla volumetric head magnetic resonance imaging, [18F]-fluorodeoxyglucose and [11C] Pittsburg compound B positron emission tomography scanning. Twelve subjects were identified as having apraxia of speech without any signs of aphasia based on a comprehensive battery of language tests; hence, none met criteria for primary progressive aphasia. These subjects with primary progressive apraxia of speech included eight females and four males, with a mean age of onset of 73 years (range: 49–82). There were no specific additional shared patterns of neurological or neuropsychological impairment in the subjects with primary progressive apraxia of speech, but there was individual variability. Some subjects, for example, had mild features of behavioural change, executive dysfunction, limb apraxia or Parkinsonism. Voxel-based morphometry of grey matter revealed focal atrophy of superior lateral premotor cortex and supplementary motor area. Voxel-based morphometry of white matter showed volume loss in these same regions but with extension of loss involving the inferior premotor cortex and body of the corpus callosum. These same areas of white matter loss were observed with diffusion tensor imaging analysis, which also demonstrated reduced fractional anisotropy and increased mean diffusivity of the superior longitudinal fasciculus, particularly the premotor components. Statistical parametric mapping of the [18F]-fluorodeoxyglucose positron emission tomography scans revealed focal hypometabolism of superior lateral premotor cortex and supplementary motor area, although there was some variability across subjects noted with CortexID analysis. [11C]-Pittsburg compound B positron emission tomography binding was increased in only one of the 12 subjects, although it was unclear whether the increase was actually related to the primary progressive apraxia of speech. A syndrome characterized by progressive pure apraxia of speech clearly exists, with a neuroanatomic correlate of superior lateral premotor and supplementary motor atrophy, making this syndrome distinct from primary progressive aphasia.
A collagen/gelatin-binding decapeptide derived from bovine propolypeptide of von Willebrand factor.

Propolypeptide of von Willebrand factor (pp-vWF) binds to type I collagen, and we have reported that a binding domain exists in a 21.5/21-kDa fragment originated from the C-terminal portion [Takagi, J., Fujisawa, T. , Sekiya, F. , & Saito, Y. (1991) J. Biol. Chem. 266, 5575-5579]. The collagen-binding property of the 21.5/21-kDa fragment was compared with that of the intact pp-vWF. Although pp-v WF preferentially binds to native type I collagen fibrils, the isolated fragment no longer has this specificity and binds well to collagen of other types in the native and heat-denatured states. In order to determine the critical site that mediates this collagen/gelatin binding, several peptides were synthesized based on the primary structure of the 21.5/21-kDa fragment. Among these, a 25-residue peptide strongly inhibited the binding of the 125I-labeled 21.5/21-kDa fragment to collagen. Using this inhibitory effect as an index, the binding site was defined to the sequence as follows: WREPSFCALS. Furthermore, a decapeptide of this sequence bound to collagen and gelatin, indicating that this sequence is responsible for the binding of the 21.5/21-kDa fragment to collagen/gelatin.
Signature Files and Signature File Construction

DTD Graph from an XML Document: A Reverse Engineering Approach Joseph Fong and Herbert Shiu (2010). Principle Advancements in Database Management Technologies: New Applications and Frameworks (pp. 204-224). www.igi-global.com/chapter/abstract-dtd-graph-xml-document/39357? camid=4v1a A Measurement Ontology Generalizable for Emerging Domain Applications on the Semantic
A phase 2, single agent study of CI-1033 administered at two doses in ovarian cancer patients who failed platinum therapy.

5054 Background: Ovarian cancer that is refractory to platinum-based therapies is a therapeutic challenge, particularly in the setting of erbB-1 and -2 receptor over- expression. CI-1033 is an irreversible, 4-anilinoquinazoline pan-erbB tyrosine kinase inhibitor with activity in a wide variety of human tumor xenografts, particularly erbB+ tumors including ovarian SK-OV-3. METHODS This study evaluated 50- and 200mg doses of CI-1033, given daily for 21 days repeated every 28 until disease progression in pts with platinum-refractory ovarian cancer. Primary eligibility criteria included disease progression following platinum therapy, measurable disease, and Karnofsky Performance Status (KPS) of 60-100. Baseline tumor erbB receptor profiles were determined by IHC staining retrospectively in 56 of the 105 pts. Endpoints included 1-yr progression-free survival (PFS) and overall survival (OS). RESULTS Between January and May of 2002, 105 patients were enrolled. Baseline characteristics were balanced between both groups: overall median number of prior chemotherapy regimens was 4 (1-12); median KPS was 90. Fifty-three pts received 146 cycles in the 50-mg arm; 52 pts received 138 cycles in the 200-mg arm. Dose reductions were necessary in 59% of pts in the 200-mg arm predominantly due to gastrointestinal adverse effects (AEs); no pts required dose reductions in the 50-mg arm. The most common treatment-related AEs in the 50-mg arm were Grade 1-2 diarrhea (57%), asthenia (43%), and nausea (41%); AEs in the 200-mg arm were Grade 2-3 diarrhea (85%), stomatitis (69%), and rash (58%). There were no objective responders in either arm; stable disease (≥8 weeks) was achieved in 28% and 34% of pts in the 50- and 200-mg arms, respectively. One-yr PFS rates were 0% and 9%, and 1-year OS were 37% and 38% for 50- and 200-mg dose group, respectively. No associations were apparent between baseline tumor erbB expression profiles and PFS or OS. CONCLUSIONS CI-1033 has minimal activity in this heavily pretreated, platinum-refractory population. The 50-mg dosing regimen was better tolerated than the 200-mg arm, with gastrointestinal AEs being most common toxicities. [Table: see text].
Activation of benzylic alcohols to mutagens by human hepatic sulphotransferases.

Four primary and five secondary benzylic alcohols derived from polycyclic aromatic hydrocarbons were tested for mutagenicity in Salmonella typhimurium TA98 in the presence of 3'-phosphoadenosine-5'-phosphosulphate, the cofactor for sulphotransferases, and varying amounts of hepatic cytosol from three or four different human subjects, a 3-year-old child, an adult female, an adult male and one unknown. All compounds except one, 4H-cyclopenta[def]phenanthren-4-ol, were activated to mutagens. The interindividual variation in the activities was at most 3-fold and the individual activities towards the different substrates were correlated with each other. The same compounds had previously been tested in the presence of hepatic cytosol from rats and all compounds activated in one species were also activated in the other species. However, there were marked quantitative differences, which were further complicated by the observation of a substantial sex difference in the rat. Male and female rat liver cytosol showed higher sulphotransferase activities towards 1-hydroxymethylpyrene, 9-hydroxymethylanthracene, 7-hydroxymethyl-12-methylbenz[a]anthracene and 4H-cyclopenta[def]chrysen-4-ol than human liver cytosol. The largest difference in activity was seen with 7-hydroxymethyl-12-methylbenz[a]anthracene, reaching a factor of approximately 100 between human and female rat. However, with other benzylic alcohols, the activity in human liver cytosol was in the range of that found in the less active sex of rat (3-hydroxy-3,4-dihydrocyclopenta[cd]pyrene, 2-hydroxymethylpyrene) or the more active sex of rat [1-(1-pyrenyl)ethanol]. (ABSTRACT TRUNCATED AT 250 WORDS)
‘Cough‐triggered’ tuberculosis screening among adults with diabetes in Tanzania

Diabetes increases the risk of tuberculosis and the prevalence of diabetes is rising in tuberculosis‐endemic regions such as sub‐Saharan Africa. Resource‐appropriate strategies for tuberculosis case finding among African adults with diabetes are needed. The aims of this study were to determine prevalence of tuberculosis and evaluate one screening strategy among adult Tanzanians with diabetes.
Design of low-complexity wideband beamformers with temporal sparsity

In this paper, a method for the design of a wideband beamformer with temporal sparsity is proposed. The main advantage of the proposed design is its low implementation complexity as the number of non-zero valued coefficients is reduced significantly. It is formulated as an l1 minimisation problem with an added frequency invariant (FI) constraint if an FI response is desired. As a result, sparsity in the tapped delay-line (TDL) coefficients associated with each sensor is introduced and at the same time the designed response still gives an acceptable performance in terms of matching a desired response.
Effective Planning with More Expressive Languages

Most of the key computational ideas in classical planning assume a simple planning language where action preconditions and goals are conjunctions of propositional atoms. This is to facilitate the definition and computation of heuristics for guiding the search for plans. In this work, however, we show that this modeling choice hides important structural information, resulting in poorer heuristics and weaker planning performance. To address this, we show how relaxed plan heuristics can be lifted to a variable-free first-order planning language, Functional STRIPS, where atomic formulas can involve arbitrary terms. The key idea is to regard the set of atoms that are reachable in a propositional layer of the relaxed planning graph as encoding a set of logical first-order interpretations. A precondition or goal formula is then regarded as reachable in a propositional layer, potentially adding new atoms to the next layer, when the set of atoms in the layer makes the formula satisfiable according to the rules of first-order logic. While this satisfiability test and the resulting heuristics turn out to be intractable, we show how a meaningful polynomial approximation can be obtained by formulating the satisfiability problem as a CSP and applying constraint propagation techniques. Experiments illustrating the computational value of planning with more expressive languages are also reported.
Search Strategies for an Anytime Usage of the Branch and Prune Algorithm

When applied to numerical CSPs, the branch and prune algorithm (BPA) computes a sharp covering of the solution set. The BPA is therefore impractical when the solution set is large, typically when it has a dimension larger than four or five which is often met in underconstrained problems. The purpose of this paper is to present a new search tree exploration strategy for BPA that hybridizes depth-first and breadth-first searches. This search strategy allows the BPA discovering potential solutions in different areas of the search space in early stages of the exploration, hence allowing an anytime usage of the BPA. The merits of the proposed search strategy are experimentally evaluated.
The gut microbiome in health and in disease

Purpose of review Recent technological advancements and expanded efforts have led to a tremendous growth in the collective knowledge of the human microbiome. This review will highlight some of the important recent findings in this area of research. Recent findings Studies have described the structure and functional capacity of the bacterial microbiome in the healthy state and in a variety of disease states. Downstream analyses of the functional interactions between the host and its microbiome are starting to provide mechanistic insights into these interactions. These data are anticipated to lead to new opportunities for diagnosis, prognosis, and treatment of a variety of human diseases. Summary There is a fast growing collection of data describing the structure and functional capacity of the microbiome in a variety of conditions available to the research community for consideration and further exploration. Ongoing efforts to further characterize the functions of the microbiome and the mechanisms underlying host–microbe interactions will provide a better understanding of the role of the microbiome in health and disease.
An Approach to the Evaluation of Usefulness as a Social Construct Using Technological Frames

Abstract This article describes an investigation of the way usefulness of an information system is shaped by sociocultural factors in a work context. It presents technological frames as a conceptual tool that helps to understand usefulness from this point of view. It suggests that developers and users shape their experience of the usefulness of a system through these technological frames. This is illustrated with a qualitative study, in which developers' expectations of the usefulness of an enterprise resource planning system differed from those of users, who experienced the usefulness of the same system in diverse ways. Technological frames are proposed as an analysis framework for assessing how context and local culture shape the utility and usability of systems in situ, that is, once they are deployed to their actual contexts of use.
Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma.

BACKGROUND The shelterin complex protects chromosomal ends by regulating how the telomerase complex interacts with telomeres. Following the recent finding in familial melanoma of inactivating germline mutations in POT1, encoding a member of the shelterin complex, we searched for mutations in the other five components of the shelterin complex in melanoma families. METHODS Next-generation sequencing techniques were used to screen 510 melanoma families (with unknown genetic etiology) and control cohorts for mutations in shelterin complex encoding genes: ACD, TERF2IP, TERF1, TERF2, and TINF 2. Maximum likelihood and LOD [logarithm (base 10) of odds] analyses were used. Mutation clustering was assessed with χ(2) and Fisher's exact tests. P values under . 05 were considered statistically significant (one-tailed with Yates' correction). RESULTS Six families had mutations in ACD and four families carried TERF2IP variants, which included nonsense mutations in both genes (p.Q320X and p.R364X, respectively) and point mutations that cosegregated with melanoma. Of five distinct mutations in ACD, four clustered in the POT1 binding domain, including p.Q320X. This clustering of novel mutations in the POT1 binding domain of ACD was statistically higher (P = .005) in melanoma probands compared with population control individuals (n = 6785), as were all novel and rare variants in both ACD (P = .040) and TERF2IP (P = .022). Families carrying ACD and TERF2IP mutations were also enriched with other cancer types, suggesting that these variants also predispose to a broader spectrum of cancers than just melanoma. Novel mutations were also observed in TERF1, TERF2, and TINF2, but these were not convincingly associated with melanoma. CONCLUSIONS Our findings add to the growing support for telomere dysregulation as a key process associated with melanoma susceptibility.
Effects of roxithromycin and erythromycin on interleukin 8-induced neutrophil recruitment and goblet cell secretion in guinea pig tracheas

Inhaled interleukin 8 caused an increase in goblet cell secretion in guinea pig tracheas, which was accompanied by mucosal infiltration of neutrophils. These responses were inhibited by pretreatment with roxithromycin or erythromycin in a dose-dependent fashion. Macrolides may thus be a value in protecting against neutrophil-associated airway hypersecretion.
The Na+ Channel Inactivation Gate Is a Molecular Complex

Electrical activity in nerve, skeletal muscle, and heart requires finely tuned activity of voltage-gated Na+ channels that open and then enter a nonconducting inactivated state upon depolarization. Inactivation occurs when the gate, the cytoplasmic loop linking domains III and IV of the α subunit, occludes the open pore. Subtle destabilization of inactivation by mutation is causally associated with diverse human disease. Here we show for the first time that the inactivation gate is a molecular complex consisting of the III-IV loop and the COOH terminus (C-T), which is necessary to stabilize the closed gate and minimize channel reopening. When this interaction is disrupted by mutation, inactivation is destabilized allowing a small, but important, fraction of channels to reopen, conduct inward current, and delay cellular repolarization. Thus, our results demonstrate for the first time that physiologically crucial stabilization of inactivation of the Na+ channel requires complex interactions of intracellular structures and indicate a novel structural role of the C-T domain in this process.
Etretinate augments interferon beta-1b effects on suppressor cells in multiple sclerosis.

BACKGROUND Interferon beta treatment is only partially effective in multiple sclerosis (MS) suggesting a potential role for adjunctive therapies. Retinoids can augment the clinical efficacy of type 1 interferons in patients with cancer. We reasoned that the same might hold in MS. Interferon beta-1b added to peripheral blood mononuclear cells in vitro partially reverses the CD8 suppressor cell defect of patients with MS. All-trans retinoic acid added to peripheral blood mononuclear cells from untreated patients with MS or from controls potentiates this ability of interferon beta-1b to augment CD8 suppressor cell function in vitro. OBJECTIVE To determine whether retinoid administration to patients with MS who are being treated with interferon beta-1b augments their CD8 suppressor cell function. SETTING A university hospital MS clinic. PARTICIPANTS Patients with MS who were being treated with interferon beta-1b, 14 patients with secondary progressive MS and 3 patients with relapsing remitting MS. RESULTS Seventeen patients with MS received etretinate treatment for up to 6 months. Planned dosing was 10 mg 3 times daily for the first month, 25 mg twice daily for the second and third months, and 10 mg twice daily thereafter. The 25-mg twice daily dose was not well tolerated and of the 14 patients who remained in the phase 1 clinical trial through month 3 dose reduction to 10 mg thrice daily was required in 1 patient and to 10 mg twice daily in 4 patients. Eleven patients completed the trial. Etretinate treatment significantly augmented suppressor function over baseline values at 1, 3, and 6 months. No meaningful change was noted in disability or quality of life over the course of the phase 1 clinical trial. Neuropsychological testing of completers suggested improvement on selected aspects of verbal memory at 6 months compared with baseline values. CONCLUSIONS Etretinate treatment at a dose of 10 mg twice or three times daily augments suppressor cell function in patients with MS receiving interferon beta-1b. Higher dose etretinate treatment (25 mg twice daily) is poorly tolerated by patients with MS. Even at 10 mg twice daily adverse experiences involving the mucous membranes and the skin become troublesome for some, but not all, patients. Whether pulse therapy or administration of retinoid restricted to the day of interferon beta dosing will also augment suppressor function, while being better tolerated, remains to be determined.
Efficient Modular Arithmetic for SIMD Devices

This paper describes several new improvements of modular arithmetic and how to exploit them in order to gain more efficient implementations of commonly used algorithms, especially in cryptographic applications. We further present a new record for modular multiplications per second on a single desktop computer as well as a new record for the ECM factoring algorithm. This new results allow building personal computers which can handle more than 3 billion modular multiplications per second for a 192 bit module at moderate costs using modern graphic cards.