Miracle-dz/UniFAR-FTUs huggingface dataset:
Selection for drinking in the dark alters brain gene coexpression networks.

BACKGROUND Heterogeneous stock (HS/NPT) mice have been used to create lines selectively bred in replicate for elevated drinking in the dark (DID). Both selected lines routinely reach a blood ethanol (EtOH) concentration (BEC) of 1.00 mg/ml or greater at the end of the 4-hour period of access in Day 2. The mechanisms through which genetic differences influence DID are currently unclear. Therefore, the current study examines the transcriptome, the first stage at which genetic variability affects neurobiology. Rather than focusing solely on differential expression (DE), we also examine changes in the ways that gene transcripts collectively interact with each other, as revealed by changes in coexpression patterns. METHODS Naïve mice (N = 48/group) were genotyped using the Mouse Universal Genotyping Array, which provided 3,683 informative markers. Quantitative trait locus (QTL) analysis used a marker-by-marker strategy with the threshold for a significant logarithm of odds (LOD) set at 10.6. Gene expression in the ventral striatum was measured using the Illumina Mouse 8.2 array. Differential gene expression and the weighted gene coexpression network analysis (WGCNA) were implemented largely as described elsewhere. RESULTS Significant QTLs for elevated BECs after DID were detected on chromosomes 4, 14, and 16; the latter 2 were associated with gene-poor regions. None of the QTLs overlapped with known QTLs for EtOH preference drinking. Ninety-four transcripts were detected as being differentially expressed in both selected lines versus HS controls; there was no overlap with known preference genes. The WGCNA revealed 2 modules as showing significant effects of both selections on intramodular connectivity. A number of genes known to be associated with EtOH phenotypes (e.g., Gabrg1, Glra2, Grik1, Npy2r, and Nts) showed significant changes in connectivity. CONCLUSIONS We found marked and consistent effects of selection on coexpression patterns; DE changes were more modest and less concordant. The QTLs and differentially expressed genes detected here are distinct from the preference phenotype. This is consistent with behavioral data and suggests that the DID and preference phenotypes are markedly different genetically.
Optimized Control of DFIG-Based Wind Generation Using Sensitivity Analysis and Particle Swarm Optimization

Optimal control of large-scale wind farm has become a critical issue for the development of renewable energy systems and their integration into the power grid to provide reliable, secure, and efficient electricity. Among many enabling technologies, the latest research results from both the power and energy community and computational intelligence (CI) community have demonstrated that CI research could provide key technical innovations into this challenging problem. In this paper, we propose a sensitivity analysis approach based on both trajectory and frequency domain information integrated with evolutionary algorithm to achieve the optimal control of doubly-fed induction generators (DFIG) based wind generation. Instead of optimizing all the control parameters, our key idea is to use the sensitivity analysis to first identify the critical parameters, the unified dominate control parameters (UDCP), to reduce the optimization complexity. Based on such selected parameters, we then use particle swarm optimization (PSO) to find the optimal values to achieve the control objective. Simulation analysis and comparative studies demonstrate the effectiveness of our approach.
Exploitation of 3D images for face authentication under pose and illumination variations

An appearance-based face authentication system integrating 2D color or intensity images and 3D data is presented. The proposed system is based on a low-cost 3D and color sensor, capable of synchronous real-time acquisition of 3D images and associated color images. Novel algorithms are proposed that exploit depth information and prior knowledge of face geometry and symmetry to achieve robust face detection, localization and authentication under conditions of background clutter, occlusion, face pose alteration and harsh illumination. A method for the enrichment of face databases with synthetically generated views depicting variations in pose and illumination is proposed to cope with head rotations and illumination variations, avoiding a cumbersome enrolment process. The performance of the proposed authentication scheme is tested thoroughly on a face database of 1500 images, recorded with the 3D acquisition system. Experimental results demonstrate significant gains resulting from the combined use of depth and color or intensity information, in comparison to the use of 2D images alone.
Material Selection of Thermoplastic Matrix for Hybrid Natural Fiber/Glass Fiber Polymer Composites Using Analytic Hierarchy Process Method

In this paper, Analytic Hierarchy Process (AHP) met hod was applied in the selection of the most suitab le thermoplastic polymer matrix for hybrid natural fib er/ glass fiber polymer composites application. The hybrid polymer composites will later be applied for the construction of automotive parking brake lever component. The material selection process was condu cte based on product design specifications of the parking brake lever to meet the operational require ments as well as sustainability advantages. Based o n literature review, six (6) typical thermoplastic ma trices used in natural fiber polymer composites fabrication were identified as the alternatives to satisfy the objectives. A 4-level AHP structure was applied in this project which consists of four (4) main criteria and seven (7) sub-criteria. Final sel ection results revealed that low density polyethylene (LDP E) thermoplastic matrix is the most suitable candidate material for the intended application compared to o ther identified thermoplastic matrices based on the highest priority ranking score. Consistency analysi s was also performed where the overall consistency ratio throughout the analysis obtained was within t e acceptable value of less than 0.10. Furthermore, t further validate the obtained results, sensitivity analysis was also conducted by varying the weight o f the main criteria. Results from the sensitivity analysi s also showed that LDPE matrix emerged with the highest score in all simulated scenarios which corr ectly respond to the results suggested from the AHP method.
A clinical comparison of etomidate-lipuro, propofol and admixture at induction

Objective: The purpose of this study was to compare etomidate-lipuro and propofol and 50%, (1:1) admixture of these agents at induction with special reference to injection pain, hemodynamic changes, and myoclonus. Methods: Ninety patients were assigned at random to three groups in which induction was performed with either etomidate-lipuro, propofol or etomidate-lipuro–propofol admixture. After monitorization with bispectral index (BIS) all agents were given with infusion with a perfuser at a constant rate of 200 ml/min till the BIS values decreased to 40. Blood pressure and heart rate were measured every 30 s at this period. Patients were asked for pain at the injection site and observed visually for myoclonus. The time BIS values decreased to 40 (BIS 40 time) and total amounts of induction doses were measured. Results: BIS 40 time measurements were P > E > PE (199.4 ± 40.9, 176.9 ± 31.6, 163.5 ± 20.6 s). The hemodynamic (systolic, diastolic and mean blood pressures, heart rate) changes were minimal in group PE than other two groups (P = 0.017). The intensity of myoclonus was graded as mild in 9, moderate in 12, and severe in 5 patients in the group E (76.3%). Myoclonus was not observed in group PE and group P. There were no injection pain in group PE as the incidence were (83.8%) in group P and in (63.2%) group E. Conclusion: Incidence of hemodynamic changes, myoclonus, and injection pain is significantly lower in group PE. BIS 40 times is least in group PE. We concluded that 1:1 admixture of etomidate-lipuro and propofol is a valuable agent for induction.
Search for endophytic diazotrophs in barley seeds

Eight endophytic isolates assigned to Pseudomonas, Azospirillum, and Bacillus genera according to pheno-genotypic features were retrieved from barley seeds under selective pressure for nitrogen-fixers. Genetic relationships among related isolates were investigated through RAPD. Six isolates displayed nitrogen-fixing ability, while all could biosynthesize indolacetic acid in vitro and showed no antibiosis effects against Azospirillum brasilense Az39, a recognized PGPR.
Morphology of root canals in lower human premolars

Background The knowledge of the root canal morphology and the possible anatomical variations of mandibular premolars are important for the successful endodontic treatment of such cases. The aim of this study was to investigate the presence of two or three root canals in extracted first and second mandibular premolars which were collected from health centers in Syria. Materials and Methods: One hundred and ten human mandibular premolars (70 first premolars and 40 second premolars) with fully developed roots were investigated. After access the cavity of the teeth, the root canals were explored and radiographs were taken. Results: Premolars with one canal were found in 87% of cases (53% first premolar and 34% second premolar) and premolars with two canals were found in 12% of cases (10% first premolar and 2% second premolar). There was just one case (1%) where a first premolar had three canals. These differences were statistically significant with P<0.05. Conclusion: Clinicians should be aware of the anatomical variation in the mandibular premolars and be able to apply this knowledge in radiographical and clinical interpretation.
Capacity analysis in M-WiMAX uplink considering the effect of adjacent channel interference from WCDMA downlink

In this paper, we analyze the M-WiMAX UL capacity limits under 2-tier cell layout, considering the effects of random user position, path loss models, fading channel and adjacent channel interference from WCDMA downlink. To account for the requirement of the system packet error rate and the supported MCS (modulation and coding scheme) levels, we propose a MCS-based capacity analysis method, which is verified through system-level Monte-Carlo simulation. Furthermore, a comparison between the conventional Shannon method and the proposed MCS-based method is presented.
Association of angiotensin I converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms with breast cancer prognostic factors in iranian population

It has been indicated that renin‐angiotensin system (RAS) has role in various steps of cancer progression. The presence of RAS components has been shown in normal and breast cancer tissue. Insertion/Deletion (I/D) is one of angiotensin I converting enzyme (ACE) polymorphisms and A1166C is one of Angiotensin II type‐1 receptor (AT1R) polymorphisms which have been associated with various diseases such as cardiovascular diseases. In the present study, we aimed to substantiate the putative significance of ACE and AT1R on breast cancer biology by investigating the influence of their gene polymorphisms on breast cancer progression. The I/D and A1166C polymorphisms were evaluated by using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP), respectively in 70 breast cancer patients diagnosed with invasive breast cancer and 70 healthy women. Breast cancer prognostic factors were obtained from medical and pathology reports of patients. There was no significant difference between cases and controls for ACE (I/D) (P = 0.15) and AT1R (A1166C) genotypes (P = 0.86). In breast cancer patients, when DD genotype was used as reference group, the combination of II and ID genotypes was associated with increased HER‐2 expression (P = 0.020; OR, 4.58; 95% CI, 1.26–16.60). Also, when AA genotype was used as reference group, the AC genotype was associated with higher tumor TNM stage (P = 0.024; OR, 4.66; 95% CI, 1.18–18.35). This is the first study indicating that ACE (I/D) polymorphism is associated with HER‐2 expression and AT1R (A1166C) polymorphism is associated with tumor TNM stage in breast cancer patients. © 2010 Wiley‐Liss, Inc.
Germ granules and the control of mRNA translation

Germ granules are an evolutionarily conserved feature of germ cell cytoplasm and are critical for gametogenesis and embryonic development. Germ granules are highly enriched for RNA and RNA‐binding proteins and are key centers for post‐transcriptional gene regulation in germ cells. Over the last 20 years, the molecular events in germ granule function and formation in several organisms have begun to be revealed. This review seeks to give an overview of some conserved features of germ granules and highlights a conserved strategy for regulating translation of maternal mRNAs. © 2012 IUBMB IUBMB Life, 64(7): 586–594, 2012
Consistency Measures for Hesitant Fuzzy Linguistic Preference Relations

Hesitant fuzzy linguistic term sets (HFLTSs) are used to deal with situations in which the decision makers (DMs) think of several possible linguistic values or richer expressions than a single term for an indicator, alternative, variable, etc. Compared with fuzzy linguistic approaches, they are more convenient and flexible to reflect the DMs' preferences in decision making. For further applications of HFLTSs to decision making, we develop a concept of hesitant fuzzy linguistic preference relations (HFLPRs) as a tool to collect and present the DMs' preferences. Due to the importance of the consistency measures using preference relations in decision making, we develop some consistency measures for HFLPRs to ensure that the DMs are being neither random nor illogical. A consistency index is defined to establish the consistency thresholds of HFLPRs to measure whether an HFLPR is of acceptable consistency. For HFLPRs with unacceptable consistency, we develop two optimization methods to improve the consistency until they are acceptable. Several illustrative examples are given to validate the consistency measures and the optimization methods.
the DARPA IT-MANET

The following item is made available as a courtesy to scholars by the author(s) and Drexel University Library and may contain materials and content, including computer code and tags, artwork, text, graphics, images, and illustrations (Material) which may be protected by copyright law. Unless otherwise noted, the Material is made available for non profit and educational purposes, such as research, teaching and private study. For these limited purposes, you may reproduce (print, download or make copies) the Material without prior permission. All copies must include any copyright notice originally included with the Material. You must seek permission from the authors or copyright owners for all uses that are not allowed by fair use and other provisions of the U.S. Copyright Law. The responsibility for making an independent legal assessment and securing any necessary permission rests with persons desiring to reproduce or use the Material. This research was supported by NSF grant no. 0635003 (Weber), no. 0634979 (Andrews), and the DARPA IT-MANET program, grant no. W911NF-07-1-0028 (all authors).
Turning the Tides: Coping with Trauma and Addiction through Residential Adolescent Group Therapy.

TOPIC Evidence-based group therapy in an inpatient setting that provides an integrated treatment approach for both trauma and addiction in female adolescents. PURPOSE The purpose of this evidence-based practice (EBP) project was to implement and assess the impact of an integrated group therapy approach for both posttraumatic stress disorder (PTSD) and substance use disorder (SUD) in adolescent females as part of a residential treatment program. SOURCES The Iowa Model of EBP guided this EBP project. Judith Herman's three-stage model of trauma recovery and the Skills Training in Affective and Interpersonal Regulation (STAIR) model served as the theoretical framework for the group therapy curriculum. Two programs, Seeking Safety, by Lisa Najavits and VOICES, by Stephanie Covington, provided a guide for group topics and activities. CONCLUSIONS Patients that participated in Turning the Tides© group therapy curriculum reported a decrease in overall PTSD symptoms and decreased functional impairment scores, based on the Child PTSD Symptoms Scale. However, there was a statistically significant increase in the use of as needed medications following the completion of group therapy. Postgroup evaluations from patients indicated a genuine desire to engage in the group therapy as well as an increased sense of trust with facilitators. Implications for psychiatric nursing include the delivery of safe, quality patient care as evidenced by positive improvement in patient outcomes.
What people with PTSD symptoms do (and do not) know about PTSD: A national survey

If people do not recognize posttraumatic stress disorder (PTSD) symptoms, they may not realize they are suffering from the disorder. Likewise, if people do not know that effective treatments exist, they may be unlikely to seek care. This study examined what people with PTSD symptoms know about PTSD and its treatment. We hypothesized that military service and prior receipt of PTSD treatment would be associated with greater PTSD knowledge.
Night eating syndrome presenting as anorexia in an athlete: case report and review.

Night eating syndrome (NES) was first described by Stunkard in 1955 as ‘‘morning anorexia, evening or nocturnal hyperphagia in a fully conscious state, and insomnia’’ (21). Over time, the syndrome has been further characterized to distinguish it from other forms of nighttime eating. Although some debate still exists, NES encompasses a few key behaviors, including evening hyperphagia (or late night eating before initiating sleep) and eating after awakening from sleep (night eating) either in a fully or semi-conscious state (11). This is in contrast to binge eating disorder (BED), which describes episodes of consuming large quantities of food in discrete time periods without control (23), or sleep related eating disorder (SRED), which refers to involuntary nocturnal eating, often of bizarre foods or inedible items, that occurs after awakening (25). Late-night eating also can be found in other diagnoses, such as bulimia nervosa or dissociative disorders, but in these cases it is usually a part of a group of symptoms rather than the central problem. The hallmark of NES is a delay of caloric intake until the evening and night hours. Birketvedt revealed that night eaters consume 56% of their daily caloric intake between the hours of 8 p.m. and 6 a.m., compared with 15% by control subjects (5). The foods consumed during episodes of evening hyperphagia and night eating tend to be carbohydrate-rich (7), with a high carbohydrate to protein ratio of 7:1. Nighttime awakenings are common among night eaters, and 950% of these episodes were associated with food intake, compared with 0% in control subjects (5). CASE PRESENTATION
Rationale for adjuvant chemotherapy

Surgery or radiation therapy fails to cure clinically evident human cancer, in the main, if the disease is systemic (has metastasized) when first recognized, because neither modality can effectively remove or kill distant and/or unrecognized metastases. Starting drug treatment of a tumor when it is first clinically recognized, or when it re‐presents following noncurative surgical or radiological treatment, fails to cure over 90% of cancer in man because the body burden of tumor cells exceeds the tumor cell kill potential of nearly all of the most effective drugs or drug combinations against most tumors. The indicated approach to improving cure rates under these circumstances is to use chemotherapy as an adjuvant to effective (life‐prolonging) but noncurative surgical and/or radiological treatment. Surgical adjuvant chemotherapy of carcinoma of the breast and osteogenic sarcoma has already been shown to increase the disease‐free interval over that obtained with surgery alone, and the probability of having achieved significant increases in long‐term cure rates is high. Laboratory studies with transplantable metastatic lung, breast, and colon carcinomas and melanotic melanoma, and with a spontaneous breast carcinoma of mice, all of which are uniformly fatal if untreated, have shown that: 1) the incidence of metastatic disease is directly related to tumor mass, 2) surgical cure rates drop as tumor mass at surgery increases, 3) grossly evident primary tumors are generally not curable by drug treatment, and 4) surgical adjuvant chemotherapy increases the long‐term cure rates with all of these tumors and significantly increases the life span of treatment failures. Effective surgical adjuvant chemotherapy is both dose‐responsive and related to the body burden of metastatic tumor at time of drug treatment. The effectiveness of surgical adjuvant chemotherapy decreases 1) as the tumor staging is advanced prior to surgery, 2) as the interval from surgery to start of effective chemotherapy is increased, and 3) as the drug doses are reduced. Additionally, and of critical importance to treatment planning, some drugs that are marginally effective or ineffective against the presurgical total body burden of tumor cells are curative in some to all mice with metastatic disease if given shortly after surgical removal of the primary tumor.
A Neural Approach for Compensation of Effects of PAPR Causing BER Degradations in Hiperlan2

Emergent telecommunication systems use spectral efficient multilevel modulation formats together with multicarrier schemes such as Orthogonal Frequency division multiplexing (OFDM). OFDM transmission is an efficient way to deal with multipath. However one of its major drawbacks is its sensitivity to nonlinear distortions due to its greatly variable envelope and high peak to average power ratio (PAPR). Nonlinear distortions are mainly introduced by high power amplifiers (HPA), cause in band distortions. Misalignments in IQ modulators and demodulators causes imbalance, which results in loss of orthogonality and create intercarrier interference and spectral regrowth in an OFDM system. Nonlinear distortions also cause intermodulation effect. This degrades Bit error rate (BER) performance of the system. This paper introduces the self organization map(SOM) and parameterless self organization map(PLSOM) based and Hiperlan/2 receiver structure used for the compensation of nonlinear distortions. Simulation results presented in this paper clearly indicate the improved performance of the proposed system. Simulations are run for AWGN channel model and for two HPA models namely Travelling wave tube amplifier (TWTA) and Solid state power amplifier (SSPA), with and without SOM and PLSOM neural network blocks.
A new supervised-predictive compensation scheme for noisy speech recognition

We present a new predictive compensation scheme which makes no assumption on how the noise sources alter the speech data and which do not rely on clean speech models. Rather, this new scheme makes the (realistic) assumption that speech databases recorded under different background noise conditions are available. The philosophy of this scheme is to process these databases in order to build a "tool" which will allow it to handle new noise conditions in a robust way. We evaluate the performances of this new compensation scheme on a connected digits recognition task and show that it can perform significantly better than multi-conditions training, which is the most widely used techniques in these kind of scenarios.