Miracle-dz/UniFAR-FTUs huggingface dataset:
Predictions of Channel and Boundary-Layer Flows with a Low-Reynolds-Number Turbulence Model

2~5 However, the effects of the kinematic viscosity on the turbulence structure were ignored in many of these treatments. Consequently, the exact boundary conditions at the wall cannot be used when the turbulence Reynolds number is not high as, e.g., in flows with rapid expansions or near the transition/turbulence interface. The general goal of the present investigation was to develop a single transport model from the Navier-Stokes equation for accurate predictions of skin friction, heat transfer, and fluctuating kinetic energy distributions in transitional and turbulent flow regimes. As a first step toward this general goal, a new turbulence model valid down to the solid wall is formulated in this paper. Turbulence model equations which provide predictions of the flow within the viscous layer adjacent to the wall have been proposed by several investigators.3'4'6'7 Although the general approach of the present model is the same as that of Jones and Launder,3 the detailed proposals are substantially different. In the present study, the Taylor series expansion technique was used to systematically investigate the proper behavior of the turbulent shear stress and the kinetic energy and its rate of dissipation near a solid wall. The results were used in developing a new turbulence model which retains the proper physical behavior of the balance between the dissipation and the molecular diffusion of the turbulent kinetic energy at the solid wall. The model was applied to the problems of a fully developed turbulent channel flow and of a turbulent boundary-layer flow over a flat plate. Results on skin friction, the distribution of mean velocity, turbulent shear stress, and turbulent kinetic energy will be presented and compared with available experimental data and with the theory of Jones and Launder.
The Methylene Spacer Matters: The Structural and Luminescent Effects of Positional Isomerism of n-Methylpyridyltriazole Carboxylate Semi-Rigid Ligands in the Structure of Zn(II) Based Coordination Polymers

Two Zn(II) coordination polymers (CPs) based on n-methylpyridyltriazole carboxylate semi-rigid organic ligands (n-MPTC), with n = 3 (L1) and 4 (L2), have been prepared at the water n-butanol interphase by reacting Zn(NO3)2·4H2O with NaL1 and NaL2. This allows us to systematically investigate the influence of the isomeric positional effect on their structures. The organic ligands were obtained by saponification from their respective ester precursors ethyl-5-methyl-1-(pyridin-3-ylmethyl)-1H-1,2,3-triazole-4-carboxylate (P1) and ethyl-5-methyl-1-(pyridin-4-ylmethyl)-1H-1,2,3-triazole-4-carboxylate (P2), resulting in their corresponding sodium salt forms, 3-MPTC, and 4-MPTC. The structure of the Zn(II) CPs determined by single-crystal X-ray diffraction reveals that both CPs have 2D supramolecular hydrogen bond networks. The 2D supramolecular network of [Zn(L1)]n (1) is built up by hydrogen bond interactions between oxygen and hydrogen atoms between neighboring n-methylpyridyltriazole molecules, whereas in [Zn(L2)·4H2O]n (2) the water molecules link 1D polymeric chains forming a 2D supramolecular aggregate. The structures of 1 and 2 clearly show that the isomeric effect in the semi-rigid ligands plays a vital role in constructing the Zn(II) coordination polymers, helped by the presence of the methylene spacer group, in the final structural conformation. The structures of 1 and 2 significantly affect their luminescent properties. Thus, while 2 shows strong emission at room temperature centered at 367 nm, the emission of 1 is quenched substantially.
Diversity of the Bacterial Community Associated with Hindgut, Malpighian Tubules, and Foam of Nymphs of Two Spittlebug Species (Hemiptera: Aphrophoridae)

Spittlebugs are xylem-sap feeding insects that can exploit a nutrient-poor diet, thanks to mutualistic endosymbionts residing in various organs of their body. Although obligate symbioses in some spittlebug species have been quite well studied, little is known about their facultative endosymbionts, especially those inhabiting the gut. Recently, the role played by spittlebugs as vectors of the phytopathogenetic bacterium Xylella fastidiosa aroused attention to this insect group, boosting investigations aimed at developing effective yet sustainable control strategies. Since spittlebug nymphs are currently the main target of applied control, the composition of gut bacterial community of the juveniles of Philaenus spumarius and Lepyronia coleoptrata was investigated using molecular techniques. Moreover, bacteria associated with their froth, sampled from different host plants, were studied. Results revealed that Sodalis and Rickettsia bacteria are the predominant taxa in the gut of P. spumarius and L. coleoptrata nymphs, respectively, while Rhodococcus was found in both species. Our investigations also highlighted the presence of recurring bacteria in the froth. Furthermore, the foam hosted several bacterial species depending on the host plant, the insect species, or on soil contaminant. Overall, first findings showed that nymphs harbor a large and diverse bacterial community in their gut and froth, providing new accounts to the knowledge on facultative symbionts of spittlebugs.
Multi-omics integration to identify the genetic expression and protein signature of dilated and ischemic cardiomyopathy

Introduction Heart failure (HF) is a complex clinical syndrome leading to high morbidity. In this study, we aimed to identify the gene expression and protein signature of HF main causes, namely dilated cardiomyopathy (DCM) and ischemic cardiomyopathy (ICM). Methods Omics data were accessed through GEO repository for transcriptomic and PRIDE repository for proteomic datasets. Sets of differentially expressed genes and proteins comprising DCM (DiSig) and ICM (IsSig) signatures were analyzed by a multilayered bioinformatics approach. Enrichment analysis via the Gene Ontology was performed through the Metascape platform to explore biological pathways. Protein-protein interaction networks were analyzed via STRING db and Network Analyst. Results Intersection of transcriptomic and proteomic analysis showed 10 differentially expressed genes/proteins in DiSig (AEBP1, CA3, HBA2, HBB, HSPA2, MYH6, SERPINA3, SOD3, THBS4, UCHL1) and 15 differentially expressed genes/proteins in IsSig (AEBP1, APOA1, BGN, CA3, CFH, COL14A1, HBA2, HBB, HSPA2, LTBP2, LUM, MFAP4, SOD3, THBS4, UCHL1). Common and distinct biological pathways between DiSig and IsSig were retrieved, allowing for their molecular characterization. Extracellular matrix organization, cellular response to stress and transforming growth factor-beta were common between two subphenotypes. Muscle tissue development was dysregulated solely in DiSig, while immune cells activation and migration in IsSig. Discussion Our bioinformatics approach sheds light on the molecular background of HF etiopathology showing molecular similarities as well as distinct expression differences between DCM and ICM. DiSig and IsSig encompass an array of “cross-validated” genes at both transcriptomic and proteomic level, which can serve as novel pharmacological targets and possible diagnostic biomarkers.
Environmental Regulation Effect on Green Total Factor Productivity: Mediating Role of Foreign Direct Investment Quantity and Quality

Green total factor productivity (GTFP) is an excellent index for green development. The objective of this study was to check whether environmental regulation (ER) can affect GTFP through the mediating role of foreign direct investment (FDI) quantity and quality. Using the super-efficiency Epsilon-based measure (EBM) model and a Malmquist–Luenberger (ML) index, China’s GTFP growth was measured during 1998–2018. On this basis, we adopted a Systematic Generalized Method of Moments (SYS-GMM) to analyze the effect of ER on GTFP. The findings show that China’s GTFP declined first and rose again during the sample period. GTFP in the coastland was greater than that in the inland region. ER positively affected China’s GTFP growth. FDI quantity and quality mediated the nexus between ER and GTFP growth in the whole nation. Specifically, this mediation role of FDI quantity and quality was only significant in coastal China. Additionally, financial development can also boost GTFP growth in China. Given the importance of developing a green economy, the government should improve the FDI quality and attract green FDI.
Emergence of Clonally-Related South Asian Clade I Clinical Isolates of Candida auris in a Greek COVID-19 Intensive Care Unit

Candida auris has recently emerged as a multidrug-resistant yeast implicated in various healthcare-associated invasive infections and hospital outbreaks. In the current study, we report the first five intensive care unit (ICU) cases affected by C. auris isolates in Greece, during October 2020–January 2022. The ICU of the hospital was converted to a COVID-19 unit on 25 February 2021, during the third wave of COVID-19 in Greece. Identification of the isolates was confirmed by Matrix Assisted Laser Desorption Ionization Time of Flight mass spectroscopy (MALDI-TOF]. Antifungal susceptibility testing was performed by the EUCAST broth microdilution method. Based on the tentative CDC MIC breakpoints, all five C. auris isolates were resistant to fluconazole (≥32 μg/mL), while three of them exhibited resistance to amphotericin B (≥2 μg/mL). The environmental screening also revealed the dissemination of C. auris in the ICU. Molecular characterization of C. auris clinical and environmental isolates was performed by MultiLocus Sequence Typing (MLST) of a set of four genetic loci, namely ITS, D1/D2, RPB1 and RPB2, encoding for the internal transcribed spacer region (ITS) of the ribosomal subunit, the large ribosomal subunit region and the RNA polymerase II largest subunit, respectively. MLST analysis showed that all isolates possessed identical sequences in the four genetic loci and clustered with the South Asian clade I strains. Additionally, PCR amplification and sequencing of the CJJ09_001802 genetic locus, encoding for the “nucleolar protein 58” that contains clade-specific repeats was performed. Sanger sequence analysis of the TCCTTCTTC repeats within CJJ09_001802 locus also assigned the C. auris isolates to the South Asian clade I. Our study confirms that C. auris is an emerging yeast pathogen in our region, especially in the setting of the ongoing COVID-19 worldwide pandemic. Adherence to strict infection control is needed to restrain further spread of the pathogen.
The Humidity and Temperature Sensitivity of Clear-Air Radars in the Convective Boundary Layer

Abstract A top-down/bottom-up diffusion Model is used to evaluate the relative contributions of humidity temperature, and their cross correlation to the radar refractive index structure function paramer Cn2 in the cloud-free, convective planetary boundary layer (PBL). Profiles of Cn2 can be measured continuously in the clear air with Doppler radars. Extraction of information about PBL dynamical parameters is more straightforward if Cn2 is dominated by either moisture (Cq2) or temperature (CT2). In the lower part of the PBL the surface Bowen ratio β0 determines this dominance. In the upper part of the PBL the inversion Bowen ratio β1 is the primary determining factor. The model suggests that humidity accounts for at least 75% of Cn2 over tropical and midlatitude oceans. Polar oceans, where β0 often exceeds 0.5, may not be dominated by either temperature or moisture. Over land β0 can easily vary from 0.1 to 10. Geographical regions with β0 5 wil.
Adjoint Method and Predictive Control for 1-D Flow in NASA Ames 11-Foot Transonic Wind Tunnel

This paper describes a modeling method and a new optimal control approach to investigate a Mach number control problem for the NASA Ames 11-Foot Transonic Wind Tunnel. The flow in the wind tunnel is modeled by the 1-D unsteady Euler equations whose boundary conditions prescribe a controlling action by a compressor. The boundary control inputs to the compressor are in turn controlled by a drive motor system and an inlet guide vane system whose dynamics are modeled by ordinary differential equations. The resulting Euler equations are thus coupled to the ordinary differential equations via the boundary conditions. Optimality conditions are established by an adjoint method and are used to develop a model predictive linear-quadratic optimal con-trol for regulating the Mach number due to a test model disturbance during a continuous pitch.
Reflections on the Ethical Possibilities and Limitations of Abolitionist Praxis in Social Work

Since 2020, blatant forms of state violence within the United States have reignited attention in the field of social work, where numerous calls have been made to realign and reconsider our standing ethical values and principles. Individually, social workers are beginning to reckon with the field's role within the carceral ecosystem and reimagining practice outside the confines of the carceral state. Institutionally, however, social work's professional organizations have reacted in contradictory ways. The National Association of Social Workers (NASW) in particular has been overtly inconsistent; touting support for racial justice while also broadcasting long-standing support for and partnerships with police. Furthermore, the NASW purportedly upholds a set of professional ethics and values that center social justice while also supporting tactics that surveil and criminalize marginalized communities. This disconnect between espoused ethics and actuality of practice undermines the professional legitimacy of social work. The profession must either acknowledge the current Code of Ethics as performative or take action to bring practice into alignment with professed ethics that affirm abolitionist practices. Using institutional social work statements, this article presents a conceptual exploration of the ethical potentials and limitations of abolitionist praxis in social work, culminating with a call to action.
A Comparison of Double-End Partial Discharge Localization Algorithms in Power Cables

The double-end partial discharge (PD) measurement method is the most common method for measuring and localizing PD sources in power cables. The sensitivity of the PD sensor, the processing speed of the data acquisition unit, and the method of the PD localization algorithm are the three main keys to ensuring the accuracy of the PD source localization on power cables. A new multi-end PD localization algorithm known as segmented correlation trimmed mean (SCTM) has recently demonstrated excellent accuracy in the localization of PD sources on power cables. The algorithm, however, is only applicable to multi-end PD measurement methods. In this paper, the mathematical equation of the SCTM algorithm is customized to match the double-end PD measurement method. A MATLAB simulation was conducted to assess the performance of the SCTM algorithm in the double-end PD measurement method. The maximum peak detection (MPD) algorithm, segmented correlation (SC), and SCTM algorithm were compared as PD localization algorithms. The SC algorithms have shown that identifying the correlation bond between two cues instead of the peak of the PD signal in the MPD algorithm significantly increases the PD localization accuracy. The results show that the SCTM algorithm outperforms the MPD and SC algorithms in terms of accuracy.
A boundary-element solution of the Leontovitch problem

A boundary-element method is introduced for solving electromagnetic scattering problems in the frequency domain relative to an impedance boundary condition (IBC) on an obstacle of arbitrary shape. The formulation is based on the field approach; namely, it is obtained by enforcing the total electromagnetic field, expressed by means of the incident field and the equivalent electric and magnetic currents and charges on the scatterer surface, to satisfy the boundary condition. As a result, this formulation is well-posed at any frequency for an absorbing scatterer. Both of the equivalent currents are discretized by a boundary-element method over a triangular mesh of the surface scatterer. The magnetic currents are then eliminated at the element level during the assembly process. The final linear system to be solved keeps all of the desirable properties provided by the application of this method to the usual perfectly conducting scatterer; that is, its unknowns are the fluxes of the electric currents across the edges of the mesh and its coefficient matrix is symmetric.
Fitting Smooth-in-Time Prognostic Risk Functions via Logistic Regression

When considering treatment options, a physician ideally has access to prognoses for various spans of prospective time, meaning known risks specific for these and also for both treatment and the profile of the patient. Accordingly, investigators ideally would report estimates of such risks from clinical trials and their non-experimental counterparts. To the extent that such risk estimates have been reported at all, they have mainly been based on the semi-parametric regression model of Cox. We focus on a family of fully-parametric hazard models of an attractive, versatile form that readily allows for non-proportionality, yet models that have not been easy to fit with standard statistical software. We elaborate an approach, recently proposed, to fitting such hazard functions via logistic regression. From the fitted hazard function, cumulative incidence and, thus, risk functions of time, treatment and profile can be derived. This approach accommodates any log-linear hazard function of prognostic time, treatment, and the prognostic indicators defining the patient's prognostic profile.
Temporal trend and subgroup disparities in the prevalence and treatment of those who screen positive for depression in China: A population-based study

Background In China, improving mental health has been far behind its accomplishments for other diseases. With depression as one of the most prevalent mental disorders, the aim of this study was to evaluate temporal trends in the prevalence and treatment of those who screen positive for depression in China, by age, gender, and province. Methods We used data from three nationally representative sample surveys: the China Health and Retirement Longitudinal Study (CHARLS), the China Family Panel Studies (CFPS), and the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Depression was judged by the Centre for Epidemiologic Studies Depression Scale. Access to treatment was judged by two items: if respondents received any treatment like anti-depressants, or if respondents received counselling from a mental health professional. Survey-specific weighted regressions were fitted to estimate the temporal trend and subgroup disparities, and then pooled by meta-analysis. Results In total 168,887 respondents were investigated. The overall prevalence of China populations who screen positive for depression was 25.7% (95% CI 25.2–26.2) during 2016–2018, decreased from 32.2% (95% CI 31.6–32.8) during 2011–2012. The gender gap increased with age and had no significant improvement from 2011–2012 to 2016–2018. The prevalence of depression in developed areas is more likely to show a lower value and decreasing trend, while the prevalence in underdeveloped areas is more likely to show a higher value and increasing trend, from 2011–2012 to 2016–2018. The overall proportion of those who received any needed treatment or counselling from a mental health professional slightly increased from 2011 (0.5%, 95% CI 0.4–0.7) to 2018 (0.9%, 95% CI 0.7–1.2), and mainly occurred for older adults aged 75 and above. Conclusion The prevalence of those who screen positive for depression decreased by about 6.5% from 2011–2012 to 2016–2018 in China, but only tiny improvements were made in accessibility to mental health care. Corresponding disparities were identified in age, gender, and province.
A Highly Effective Bacteriophage-1252 to Control Multiple Serovars of Salmonella enterica

Salmonella enterica (S. enterica) is the most common foodborne pathogen worldwide, leading to massive economic loss and a significant burden on the healthcare system. The primary source of S. enterica remains contaminated or undercooked poultry products. Considering the number of foodborne illnesses with multiple antibiotic resistant S. enterica, new controlling approaches are necessary. Bacteriophage (phage) therapies have emerged as a promising alternative to controlling bacterial pathogens. However, the limitation on the lysis ability of most phages is their species-specificity to the bacterium. S. enterica has various serovars, and several major serovars are involved in gastrointestinal diseases in the USA. In this study, Salmonella bacteriophage-1252 (phage-1252) was isolated and found to have the highest lytic activity against multiple serovars of S. enterica, including Typhimurium, Enteritidis, Newport, Heidelberg, Kentucky, and Gallinarum. Whole-genome sequencing analysis revealed phage-1252 is a novel phage strain that belongs to the genus Duplodnaviria in the Myoviridae family, and consists of a 244,421 bp dsDNA, with a G + C content of 48.51%. Its plaque diameters are approximately 2.5 mm to 0.5 mm on the agar plate. It inhibited Salmonella Enteritidis growth after 6 h. The growth curve showed that the latent and rise periods were approximately 40 min and 30 min, respectively. The burst size was estimated to be 56 PFU/cell. It can stabilize and maintain original activity between 4 °C and 55 °C for 1 h. These results indicate that phage-1252 is a promising candidate for controlling multiple S. enterica serovars in food production.
Evaluation of the Antiplasmodial Properties of Andrographis paniculata (Burm.f.) and Peperomia pellucida (L.) Kunth

Plasmodium species are the infectious agents that are responsible for malaria, a disease that claims the lives of approximately 400,000 people annually. The fact that drug resistance against malaria is on the rise suggests that new antimalarial compounds need to be discovered. It is well known that medicinal plants present the best opportunity for the identification of novel antimalaria chemicals. Both the Andrographis paniculata (Burm.f.) and Peperomia pellucida (L. Kunth) species have been tested for their antiplasmodial ability against the Plasmodium falciparum strain. The P. pellucida (L. Kunth) species has also been subjected to in vitro and in vivo biological research. P. pellucida was used to isolate the steroid known as 3-hydroxy-24-ethyl-5,22-cholestadiene (1) and the triterpenoid known as 3-hydroxy-9-lanosta-7,24E-dien-26-oic acid (2). Both compounds were then tested for their activity in vitro. In the mice model, triterpenoid 2 had a substantial chemo-suppressive impact.