Miracle-dz/UniFAR-FTUs huggingface dataset:
SeCloak: ARM Trustzone-based Mobile Peripheral Control

Reliable on-off control of peripherals on smart devices is a key to security and privacy in many scenarios. Journalists want to reliably turn off radios to protect their sources during investigative reporting. Users wish to ensure cameras and microphones are reliably off during private meetings. In this paper, we present SeCloak, an ARM TrustZone-based solution that ensures reliable on-off control of peripherals even when the platform software is compromised. We design a secure kernel that co-exists with software running on mobile devices (e.g., Android and Linux) without requiring any code modifications. An Android prototype demonstrates that mobile peripherals like radios, cameras, and microphones can be controlled reliably with a very small trusted computing base and with minimal performance overhead.
Out of balance: how a binaural coincidence detection circuit responds to unilateral deafferentation

Coincidence detection is a fundamental computation used by neurons to determine when two or more sources of input are active within a brief time window. Optimal coincidence detection generally requires a delicate balance of synaptic strengths, so that no single source of input dominates the computation. This article is protected by copyright. All rights reserved.
Commercially Suitable Hybrid Multi-Visual, Inertial and Satellite Navigation Unit for Small Unmanned Aerial Vehicles

D espite extensive research background and availability of components, navigation systems for small Unmanned Aerial Vehicles (UAVs) that incorporate all the three methods (vision, inertia, and satellite-based) in a single module are not available in the market. To solve this problem we develop a commercially suitable hybrid navigation module, incorporating two state-of-the-art visual navigation algorithms, namely: Fast Semi-Direct Monocular Visual Odometry and Large-Scale Direct Monocular SLAM, while a framework called Multi-Sensor-Fusion Extended Kalman Filter is used for fusing readings from the visual sensor with the other ones. The software is implemented on top of the Robot Operating System. After prototyping the system, we test it for robustness to different motion and environment types to ensure that it is viable for commercial applications
Underreporting of food intake by dietary recall is not universal: a comparison of data from egyptian and american women.

Underreporting of dietary intake has been observed consistently in food consumption surveys in affluent societies and in clinical studies in a variety of settings. Almost one third of quantitative 24-h recalls provided by adults in U.S. surveys appear to result in estimates that are biologically implausible. Underreporting has been linked to obesity in both the U.S. and Europe, with heavier individuals underreporting to a greater degree than lean persons. A relative dearth of data exists from developing countries and those in transition to address the question whether such underreporting is universal. We present the first data from a large survey of women in a rapidly urbanizing developing country to address this question. More than 4500 adult women in Egypt provided quantitative 24-h recalls of food intake on the previous day in 1993-1994, and weights and heights were measured. We compared the data, in terms of the ratio of reported energy intake to estimated basal metabolic rate, to data from 3010 women in the 1994-1996 U.S. Continuing Survey of Food Intake by Individuals, on whom quantitative 24-h recalls were also conducted. The Egyptian women reported food intakes consistent with FAO/WHO recommendations for energy intakes for women of comparable activity levels, whereas the data for U.S. women showed underreporting consistent with other U.S. surveys. Only 10% of Egyptian women reported energy intakes below accepted criteria for plausibility, compared with one third of American women. We discuss possible reasons for this difference, including cultural and food supply differences, and methodological differences between the two surveys.
Effects of dietary β-mannanase supplementation on the additivity of true metabolizable energy values for broiler diets

Objective This experiment was conducted to determine the effects of dietary β-mannanase on the additivity of true metabolizable energy (TME) and nitrogen-corrected true metabolizable energy (TMEn) for broiler diets. Methods A total of 144 21-day-old broilers were randomly allotted to 12 dietary treatments with 6 replicates. Five treatments consisted of 5 ingredients of corn, wheat, soybean meal, corn distillers dried grains with solubles, or corn gluten meal. One mixed diet containing 200 g/kg of those 5 ingredients also was prepared. Additional 6 treatments were prepared by mixing 0.5 g/kg dietary β-mannanase with those 5 ingredients and the mixed diet. Based on a precision-fed chicken assay, TME and TMEn values for 5 ingredients and the mixed diet as affected by dietary β-mannanase were determined. Results Results indicated that when β-mannanase was not added to the diet, measured TME and TMEn values for the diet did not differ from the predicted values for the diet, which validated the additivity. However, for the diet containing β-mannanase, measured TMEn value was greater (p<0.05) than predicted TMEn value, indicating that the additivity was not validated. Conclusion In conclusion, the additivity of energy values for the mixed diet may not be guaranteed if the diet contains β-mannanase.
Spacerace – A Location Based game for mobile phones using Assisted GPS

Mobile devices and wireless data connectivity are getting more and more common nowadays. In this networked world there are going to be dozens of new applications. Location Based Services will play a major role in this area. Especially, with the current and upcoming UMTS enabled mobile phones these applications are going to be available to a larger number of customers. The most promising approach to get accurate position data on a phone is to use GPS or the enhanced Assisted GPS which is part of the UMTS standard. We developed a mobile game especially designed to demonstrate the possibilities of an Assisted GPS empowered mobile phone.
Optimal Estimation of Sea Surface Temperature from AMSR-E

The Optimal Estimation (OE) technique is developed within the European Space Agency Climate Change Initiative (ESA-CCI) to retrieve subskin Sea Surface Temperature (SST) from AQUA’s Advanced Microwave Scanning Radiometer—Earth Observing System (AMSR-E). A comprehensive matchup database with drifting buoy observations is used to develop and test the OE setup. It is shown that it is essential to update the first guess atmospheric and oceanic state variables and to perform several iterations to reach an optimal retrieval. The optimal number of iterations is typically three to four in the current setup. In addition, updating the forward model, using a multivariate regression model is shown to improve the capability of the forward model to reproduce the observations. The average sensitivity of the OE retrieval is 0.5 and shows a latitudinal dependency with smaller sensitivity for cold waters and larger sensitivity for warmer waters. The OE SSTs are evaluated against drifting buoy measurements during 2010. The results show an average difference of 0.02 K with a standard deviation of 0.47 K when considering the 64% matchups, where the simulated and observed brightness temperatures are most consistent. The corresponding mean uncertainty is estimated to 0.48 K including the in situ and sampling uncertainties. An independent validation against Argo observations from 2009 to 2011 shows an average difference of 0.01 K, a standard deviation of 0.50 K and a mean uncertainty of 0.47 K, when considering the best 62% of retrievals. The satellite versus in situ discrepancies are highest in the dynamic oceanic regions due to the large satellite footprint size and the associated sampling effects. Uncertainty estimates are available for all retrievals and have been validated to be accurate. They can thus be used to obtain very good retrieval results. In general, the results from the OE retrieval are very encouraging and demonstrate that passive microwave observations provide a valuable alternative to infrared satellite observations for retrieving SST.
Current management of oesophageal cancer

Background: Oesophageal cancer is the eighth most common cancer and it’s the sixth leading cause of death in the world. The five years overall survival is reported to be between 15-20%. The aim of this review is to highlight the current trends of management of oesophageal cancer. Methods: A literature search of PubMed/MEDLINE, EMBASE and Cochrane Library and Central Register of Controlled Trials (CENTRAL) databases up to November 2014 was conducted. Results: Oesophageal cancer accounts for almost 3% of all cancers and is the ninth most common malignancy in the UK. Diagnosis is usually made by oesophago-gastro-duodenoscopy where multiple biopsy samples must be taken from any mucosal abnormality to exclude early tumours. The management of oesophageal cancers requires a multi-disciplinary team approach involving surgeons, oncologists, radiologists, pathologists, specialist nurses, dietitians and specialists from other specialties if required. Conclusions: Treatment of oesophageal cancer is still a challenge however recent advances in surgery, endoscopic treatments and new therapeutic agents will hopefully improve prognosis.
Sodium Iodide Symporter for Nuclear Molecular Imaging and Gene Therapy: From Bedside to Bench and Back

Molecular imaging, defined as the visual representation, characterization and quantification of biological processes at the cellular and subcellular levels within intact living organisms, can be obtained by various imaging technologies, including nuclear imaging methods. Imaging of normal thyroid tissue and differentiated thyroid cancer, and treatment of thyroid cancer with radioiodine rely on the expression of the sodium iodide symporter (NIS) in these cells. NIS is an intrinsic membrane protein with 13 transmembrane domains and it takes up iodide into the cytosol from the extracellular fluid. By transferring NIS function to various cells via gene transfer, the cells can be visualized with gamma or positron emitting radioisotopes such as Tc-99m, I-123, I-131, I-124 and F-18 tetrafluoroborate, which are accumulated by NIS. They can also be treated with beta- or alpha-emitting radionuclides, such as I-131, Re-186, Re-188 and At-211, which are also accumulated by NIS. This article demonstrates the diagnostic and therapeutic applications of NIS as a radionuclide-based reporter gene for trafficking cells and a therapeutic gene for treating cancers.
On Particle Methods for Parameter Estimation in State-Space Models

Nonlinear non-Gaussian state-space models are ubiquitous in statistics, econometrics, information engineering and signal processing. Particle methods, also known as Sequential Monte Carlo (SMC) methods, provide reliable numerical approximations to the associated state inference problems. However, in most applications, the state-space model of interest also depends on unknown static parameters that need to be estimated from the data. In this context, standard particle methods fail and it is necessary to rely on more sophisticated algorithms. The aim of this paper is to present a comprehensive review of particle methods that have been proposed to perform static parameter estimation in state-space models. We discuss the advantages and limitations of these methods and illustrate their performance on simple models.
Biting off more than you can chew: sexual selection on the free amino acid composition of the spermatophylax in decorated crickets

Nuptial food gifts function to enhance male fertilization success, but their consumption is not always beneficial to females. In decorated crickets, the spermatophore transferred at mating includes a gelatinous mass, the spermatophylax, which is consumed by females after mating. However, females often discard spermatophylaxes shortly after mating, whereupon they terminate sperm transfer. We hypothesized that females discard gifts based on their assessment of the gift itself, and specifically the composition of free amino acids. We tested this hypothesis by comparing spermatophylaxes discarded by females after mating with those that were destined to be fully consumed, and employed multivariate selection analysis to quantify the strength and form of multivariate sexual selection operating on the free amino acid composition of gifts. The analysis yielded a saddle-shaped fitness surface with two local peaks. Different amino acid profiles appear to elicit continued feeding on the spermatophylax either because they offer the same level of gustatory appeal, or because they differentially affect both the gustatory appeal and texture of the spermatophylax. We conclude that the gustatory response of females to males' nuptial food gifts represents an important avenue of post-copulatory mate choice, imposing significant sexual selection on the free amino acid composition of the spermatophylax.
Heritability of life‐history tactics and genetic correlation with body size in a natural population of brook charr (Salvelinus fontinalis)

A common dimorphism in life‐history tactic in salmonids is the presence of an anadromous pathway involving a migration to sea followed by a freshwater reproduction, along with an entirely freshwater resident tactic. Although common, the genetic and environmental influence on the adoption of a particular life‐history tactic has rarely been studied under natural conditions. Here, we used sibship‐reconstruction based on microsatellite data and an ‘animal model’ approach to estimate the additive genetic basis of the life‐history tactic adopted (anadromy vs. residency) in a natural population of brook charr, Salvelinus fontinalis. We also assess its genetic correlation with phenotypic correlated traits, body size and body shape. Significant heritability was observed for life‐history tactic (varying from 0.52 to 0.56 depending on the pedigree scenario adopted) as well as for body size (from 0.44 to 0.50). There was also a significant genetic correlation between these two traits, whereby anadromous fish were genetically associated with bigger size at age 1 (rG = −0.52 and −0.61). Our findings thus indicate that life‐history tactics in this population have the potential to evolve in response to selection acting on the tactic itself or indirectly via selection on body size. This study is one of the very few to have successfully used sibship‐reconstruction to estimate quantitative genetic parameters under wild conditions.
Identification of amino acids in the Dr adhesin required for binding to decay‐accelerating factor

Members of the Dr family of adhesins of Escherichia coli recognize as a receptor the Dra blood‐group antigen present on the complement regulatory and signalling molecule, decay‐accelerating factor (DAF). One member of this family, the Dr haemagglutinin, also binds to a second receptor, type IV collagen. Structure/function information regarding these adhesins has been limited and domains directly involved in the interaction with DAF have not been determined. We devised a strategy to identify amino acids in the Dr haemagglutinin that are specifically involved in the interaction with DAF. The gene encoding the adhesive subunit, draE, was subjected to random mutagenesis and used to complement a strain defective for its expression. The resulting mutants were enriched and screened to obtain those that do not bind to DAF, but retain binding to type IV collagen. Individual amino acid changes at positions 10, 63, 65, 75, 77, 79 and 131 of the mature DraE sequence significantly reduced the ability of the DraE adhesin to bind DAF, but not collagen. Over half of the mutants obtained had substitutions within amino acids 63–81. Analysis of predicted structures of DraE suggest that these proximal residues may cluster to form a binding domain for DAF.
Leisure Activities as a Predictor of Cognitive Decline and Dementia in Old Age

Dementia is a growing medical and social problem with a devastating impact on the people affected and their respective families/care-takers. Therefore, having knowledge of the relationship between leisure activities with the dementia framework may be of extreme importance in early preventative diagnosis. In this project, by means of a transversal design, an empirical study was carried out to evaluate the principal effects of leisure in dementia development. The project included the participation of 61 elderly persons, 23 clinically diagnosed with dementia and 38 without a clinical diagnosis of dementia. This research takes into consideration one moment of the evaluation; the information having been gathered using evaluation instruments selected to this effect: Sociodemographic Questionnaire, Mini Mental State Exam, Portuguese Version, and Clinical Dementia Rating, Portuguese Version. From the results, it is highlighted that 1) leisure activities seem to be a protection factor in the development of dementia; and 2) leisure emerges as a predictor variable. The interpretation of the results, as well as their possible implications with regard to prevention and treatment, are discussed in light of the relevant literature.
Trps1 is associated with the multidrug resistance of lung cancer cell by regulating MGMT gene expression

Multidrug resistance (MDR) often leads to chemotherapy failure of lung cancer and has been linking to the cellular expression of several DNA transcription‐ and repair‐related genes such as Trps1 and MGMT. However, their roles in the formation of MDR are largely unknown. In this study, overexpression/knockdown, luciferase assay and ChIP assay were performed to study the relationship between Trps1 and MGMT, as well as their roles in MDR formation. Our results demonstrated that Trps1 and MGMT expression both increased in drug‐resistant lung cancer cell line (H446/CDDP). Silencing of Trps1 resulted in downregulation of MGMT expression and decrease in the multidrug sensitivity of H446/CDDP cells, while Trps1 overexpression exhibited the opposite effects in H446 cells. Ectopic expression of MGMT had no effect on Trps1 expression, but enhanced the IC50 values of H446 cells or rescued the IC50 values of Trps1‐silenced H446/CDDP cells in treatment of multidrug. Our data further showed that, mechanistically, Trps1 acted as a transcription activator that directly induced MGMT transcription by binding to the MGMT promoter. Taken together, we consider that upregulation of Trps1 induces MGMT transcription contributing to the formation of MDR in lung cancer cells. Our findings proved potential targets for reversing MDR in clinical chemotherapy of lung cancer.
application note genome editing Applications of Cas 9 nickases for genome engineering

Two amino acid mutations (D10A and H840A) in S. pyogenes Cas9 catalytic domains can be independently introduced into wild-type (WT) Cas9 protein to produce proteins capable of inducing single-stranded nicks rather than double-stranded breaks (DSBs). To create DSBs with Cas9 nickases, specific binding of two guide RNAs (gRNAs), located on opposite strands and in close proximity, is required. In this study, we tested multiple guide pairs with distinct orientations and spacing to identify guide designs that result in optimal genome editing with Cas9 nickases. In addition, by testing and comparing a variety of donor template designs, we investigated the ability of Cas9 nickases to mediate homology-directed repair (HDR) events in human cells.
Alloy thermodynamics in nanostructures

The importance of the interactions between alloy atoms and topological defects for the thermodynamic properties of nanostructured alloys is pointed out. The McLean model for grain boundary segregation is extended to yield an expression for the total Gibbs free energy of an alloy polycrystal. This provides a simple conceptual basis for a qualitative discussion of the thermodynamic properties of nanocrystalline alloys. It is demonstrated that certain alloy poly- or nanocrystals may reach a metastable state, where the alloy is stable with respect to variation of its total grain boundary area.
Cervical Sagittal Imbalance is a Predictor of Kyphotic Deformity After Laminoplasty in Cervical Spondylotic Myelopathy Patients Without Preoperative Kyphotic Alignment

Study Design. A retrospective cohort study. Objective. The aim of this study is to investigate the preoperative factors for postlaminoplasty kyphotic deformity in cervical spondylotic myelopathy (CSM) patients without preoperative kyphotic alignment focused on the cervical sagittal balance. Summary of Background Data. After laminoplasty (LAMP), appropriate decompression may be obtained when cervical lordosis is maintained to allow the posterior shift of the spinal cord. Therefore, LAMP is not suitable for patients with preoperative cervical kyphosis. However, we sometimes encounter patients who developed postoperative kyphosis despite normal preoperative alignment. The risk factors of postlaminoplasty kyphotic deformity for the patients without preoperative kyphotic alignment are not well known. Methods. A total of 174 consecutive patients who received a double-door LAMP for CSM without preoperative kyphotic alignment and completed a 1-year follow-up were enrolled. Cervical lateral X-ray images obtained in the standing position were measured at the preoperative stage and during a 1-year follow-up visit. The radiographic measurements included the following: (1) C2-7 lordotic angle (C2-7 angle), (2) C2-7 range of motion (C2-7 ROM), (3) CGH (center of gravity of the head)-C7 SVA, and (4) C7 slope. The clinical results were evaluated using the Japanese Orthopedic Association score system for cervical myelopathy (C-JOA score). Results. Postoperative kyphotic deformity was observed in 9 patients (5.2%). The recovery rates of the C-JOA scores at the 1-year follow-up period in the kyphotic deformity (+) group were inferior to those of the kyphotic deformity (−) group. The CGH-C7 SVA and advanced age were detected as preoperative risk factors using multivariate analysis. Cutoff values for predicting postlaminoplasty kyphotic deformity were a CGH-C7 SVA = 42 mm and an age of 75 years. Conclusion. Cervical sagittal imbalance and advanced age were the preoperative risk factors for kyphotic deformity after LAMP for CSM in patients without preoperative cervical kyphotic alignment. Level of Evidence: 4