Miracle-dz/UniFAR-FTUs huggingface dataset:
CD30 (Ki‐1) expression in adult T‐cell leukaemia/lymphoma is associated with distinctive immunohistological and clinical characteristics

Twenty‐one patients with CD30 (Ki‐1) positive lymphoma were studied from a group of 91 patients with adult T‐cell leukaemia/lymphoma. The patients were grouped into three types: diffuse CD30 positive anaplastic large cell lymphoma in 11 patients (group 1); pleomorphic type lymphoma with diffuse CD30 expression in five patients (group 2); and pleomorphic type lymphoma with positive CD30 expression in large cells but negative in medium‐sized and small cells in five patients (group 3). The patients with diffuse CD30 positive lymphomas (groups 1, 2) frequently presented with extranodal tumours (68.8%) and lymph node enlargement greater than 2 cm in diameter (50%), and rarely with leukaemic changes, bone marrow involvement and hypercalcaemia (one case of each). Patients in group 3 rarely had extranodal tumours, but had frequent leukaemic changes. Expression of intercellular adhesion molecule (ICAM‐1; CD54) by the lymphoma cells in 13 patients (81.3%) with diffuse CD30 positive lymphomas, was significantly higher than that in 33 patients (9.1%) with CD30 negative adult T‐cell leukaemia/lymphomas. No positive reaction for epithelial membrane antigen (EMA) was found in the lymphoma cells of CD30 positive cases. The overall survival in patients with diffuse CD30 positive lymphomas was better than that of CD30 negative adult T‐cell leukaemia/lymphoma patients, but showed no significant difference. These findings suggest that diffuse CD30 positive adult T‐cell leukaemia/lymphoma has unusual clinical and immunohistological findings. It is also speculated that local tumour formation and leukaemic changes in such diffuse CD30 positive cases are influenced by CD54 (ICAM‐1) expression by the lymphoma cells.
AN EMPIRICAL COMPARISON OF FLAT � SPOT ELIMINATION TECHNIQUES IN BACK � PROPAGATION NETWORKS

Back Propagation BP Rumelhart et al is a popular algorithm employed for training multi layer connectionist learning systems with non linear activation function sigmoid However BP is plagued by excruciatingly slow convergence for many applications and this drawback has been partly attributed to the Flat Spots problem Lit erature de nes at spots as regions where the derivative of the sigmoid activation function ap proaches zero and in these regions the weight changes become negligible despite the presence of considerable classi cation error Thus learn ing slows down dramatically Several researchers have addressed this problem posed by at spots Fahlman Balakrishnan Honavar In this paper we present a new way of dealing with the at spots in the output layer This new method uses a Perceptron like weight modi cation strategy to complement BP in the output layer We also report an empirical evaluation of the com parative performances of these techniques on some data sets that have been used extensively in bench marking inductive learning algorithms
Coresets forWeighted Facilities and Their Applications

We develop efficient (1 + epsiv)-approximation algorithms for generalized facility location problems. Such facilities are not restricted to being points in Ropf, and can represent more complex structures such as linear facilities (lines in Ropfd, j-dimensional flats), etc. We introduce coresets for weighted (point) facilities. These prove to be useful for such generalized facility location problems, and provide efficient algorithms for their construction. Applications include: k-mean and k-median generalizations, i.e., find k lines that minimize the sum (or sum of squares) of the distances from each input point to its nearest line. Other applications are generalizations of linear regression problems to multiple regression lines, new SVD/PCA generalizations, and many more. The results significantly improve on previous work, which deals efficiently only with special cases. Open source code for the algorithms in this paper is also available
Effectiveness of lamivudine in treatment of acute recurrent hepatitis B after liver transplantation.

In spite of long-te rm prophylaxis with hepatitis B immune globulin (HBIG), recurrence of hepatitis B virus (HBV) infection in the graft constitute s the leading cause of morbidity and mortality among patients unde rgoing liver transplantation (LT) due to HBV-induced live r cirrhosis (1). In many of these patients acce lerated HBV replication overcomes the protective effect of HBIG (2). Inte rferon therapy, which is partially effective against HBV in immunocompetent patients (3), is of limited value in post-LT HBV graft infection (4). Lamivudine , a nucleoside analog that inhibits the reverse transcriptase activity of HBV, has shown promising results in HBV infection in both immunocompetent (5) and HIV-immunosuppre ssed patients (6). Signi® cant improve ments in live r histology have been demonstrated after one year treatment with lamivudine in immunocompetent patients (7). Indeed, administration of lamivudine before and after LT has also been effective in preventing hepatitis B recurrence after LT (8), and this drug lacks the serious side effects found with other nucleoside analogues (9). We report on a LT patient in whom lamivudine was an effective therapy for acute recurrent HBV hepatitis. CASE REPORT
High-efficient slot-coupled superstrate antenna for 60GHz WLAN applications

A high-efficient and high-gain aperture coupled patch antenna with superstrate at 60 GHz is studied and presented. It is noted that adding a superstrate with a specific size will induce a significant effect on antenna gain and radiation patterns. The maximum measured gain of a single antenna with superstrate is 14.6 dBi, which is higher than that of a classical 2×2 array. It is found that the measured gain of a single antenna with superstrate increases nearly 9 dB at 60 GHz over its basic patch antenna. This superstrate antenna gives a very high estimated efficiency of 76%. The 2:1 measured VSWR bandwidth with superstrate is 6.8%. The radiation patterns are found to be broadside all over the frequency band. A 2 × 2 aperture coupled patch antenna arrays with superstrate is also studied. The corresponding maximum measured gain is 16 dBi with an efficiency of 63%, which is 4 dB higher than that of a classical 2 × 2 array at 60 GHz. The 2:1 measured VSWR bandwidth is 6.7%. The radiation patterns are found to be broadside all over the frequency band with a very low back radiation level. Hence aperture coupled superstrate antenna technology is a good candidate for high efficient high gain application at 60 GHz.
Endotracheal tube narrowing after closed-system suctioning: prevalence and risk factors.

BACKGROUND Few data exist about buildup of secretions within endotracheal tubes of patients treated with closed-system suctioning in the intensive care unit. OBJECTIVES To describe the extent, prevalence, and distribution of narrowing of endotracheal tubes related to buildup of secretions and to determine contributing factors. METHODS Forty endotracheal tubes were examined within 4 hours of extubation, after at least 72 hours of use. Data on patients' daily weight and fluid balance, ventilator humidification temperatures, and nurses' descriptions of secretions during the 3 days preceding extubation were recorded. Any secretion debris in the endotracheal tubes was weighed. At 1-cm intervals along the tube, the debris was described and the depth of the debris was measured to the nearest 0.5 mm. RESULTS Mean duration of intubation was 6.6 days. Two tubes had no debris. Mean overall depth of debris was 0.64 mm, mean greatest depth was 2.0 mm (range, 0-5 mm), and mean weight was 1.16 g. The entire tube was affected, with the greatest depth of debris at the 6- to 9-cm and 13- to 14-cm markings. Duration of intubation correlated with mean greatest depth of debris (r = 0.37, P = .02), mean overall depth of debris (r = 0.48, P = .002), and mean weight of debris (r = 0.38, P = .02). CONCLUSIONS Endotracheal tubes are markedly narrowed by the buildup of secretions after closed-system suctioning. Duration of intubation, but not endotracheal tube size or amount of secretions, was associated with the degree of narrowing.
Cheap labor can be expensive

We study markets in which consumers are trying to hire a team of agents to perform a complex task. Each agent in the market prices their labor, and based on these prices, consumers hire the cheapest available team capable of doing the job they need done. We define the cheap labor cost in such a market as the ratio of the best Nash equilibrium of the original market and the best possible Nash equilibrium of any of its submarkets, where "best" is defined with respect to consumers, i.e., we are looking at Nash equilibria in which the consumer pays the least. This definition is motivated by a "Braess-style" paradox: in certain kinds of marketplaces, competition, in the form of the availability of "cheap labor", can actually cause the prices paid by consumers to go up. We present tight bounds on the cheap labor cost for a variety of markets including s-t path markets, matroid markets and perfect bipartite matching markets. The differences in cheap labor cost across markets demonstrate the complex relationship between the combinatorial structure of the marketplace and the advantages or more precisely, disadvantages to consumers due to competition.
Temporal and noninvasive monitoring of inflammatory‐cell infiltration to myocardial infarction sites using micrometer‐sized iron oxide particles

Micrometer‐sized iron oxide particles (MPIO) are a more sensitive MRI contrast agent for tracking cell migration compared to ultrasmall iron oxide particles. This study investigated the temporal relationship between inflammation and tissue remodeling due to myocardial infarction (MI) using MPIO‐enhanced MRI. C57Bl/6 mice received an intravenous MPIO injection for cell labeling, followed by a surgically induced MI seven days later (n = 7). For controls, two groups underwent either sham‐operated surgery without inducing an MI post‐MPIO injection (n = 7) or MI surgery without MPIO injection (n = 6). The MRIs performed post‐MI showed significant signal attenuation around the MI site for the mice that received an intravenous MPIO injection for cell labeling, followed by a surgically induced MI seven days later, compared to the two control groups (P < 0.01). The findings suggested that the prelabeled inflammatory cells mobilized and infiltrated into the MI site. Furthermore, the linear regression of contrast‐to‐noise ratio at the MI site and left ventricular ejection function suggested a positive correlation between the labeled inflammatory cell infiltration and cardiac function attenuation during post‐MI remodeling (r2 = 0.98). In conclusion, this study demonstrated an MRI technique for noninvasively and temporally monitoring inflammatory cell migration into the myocardium while potentially providing additional insight concerning the pathologic progression of a myocardial infarction. Magn Reson Med, 2010. © 2009 Wiley‐Liss, Inc.
ON THE APPARENT LACK OF Be X-RAY BINARIES WITH BLACK HOLES

In our Galaxy there are 64 Be X-ray binaries known to date. Out of these, 42 host a neutron star (NS), and for the remainder the nature of the companion is unknown. None, so far, are known to host a black hole (BH). There seems to be no apparent mechanism that would prevent formation or detection of Be stars with BHs. This disparity is referred to as a missing Be–BH X-ray binary problem. We point out that current evolutionary scenarios that lead to the formation of Be X-ray binaries predict that the ratio of binaries with NSs to the ones with BHs is rather high, FNStoBH ∼ 10–50, with the more likely formation models providing the values at the high end. The ratio is a natural outcome of (1) the stellar initial mass function that produces more NSs than BHs and (2) common envelope evolution (i.e., a major mechanism involved in the formation of interacting binaries) that naturally selects progenitors of Be X-ray binaries with NSs (binaries with comparable mass components have more likely survival probabilities) over ones with BHs (which are much more likely to be common envelope mergers). A comparison of this ratio (i.e., FNStoBH ∼ 30) with the number of confirmed Be–NS X-ray binaries (42) indicates that the expected number of Be–BH X-ray binaries is of the order of only ∼0–2. This is entirely consistent with the observed Galactic sample.
Business Event Extraction System Based on SSVM

Information extraction from unstructured text data has been used essentially to provide new insights by collecting, storing, and analyzing text data in textual analysis. The research on event extraction has been recently getting more attention in information extraction area since lots of events happens and significantly affect our societies and countries. Related studies on event extraction use rules for identifying and extracting events from texts so far. However, rule based approaches have a limitation in terms of accuracy and rule construction. In this paper, we present an event extraction system which takes advantage of the machine learning method, especially SSVM. The system extracts event triggers and predefined event arguments, while existing rule based systems extract unknown event arguments. Ours provides 60.23 F1 score, which is higher than that of previous researches, in which rule based event extractions were performed. Even though rule-based and machine learning-based approaches cannot be compared against each other completely fairly, what is clear is that for the task in which event arguments are defined in advance, applying machine learning method can make better results.
StaDynA: Addressing the Problem of Dynamic Code Updates in the Security Analysis of Android Applications"

: Static analysis of Android applications can be hindered by the presence of the popular dynamic code update techniques: dynamic class loading and reflection. Recent Android malware samples do actually use these mechanisms to conceal their malicious behavior from static analyzers. These techniques defuse even the most recent static analyzers that usually operate under the "closed world'' assumption (the targets of reflective calls can be resolved at analysis time; only classes reachable from the class path at analysis time are used at runtime). In this work we proposed the solution that allows existing static analyzers to remove this assumption. This is achieved by combining static and dynamic analysis of applications in order to reveal the hidden/updated behavior and extend static analysis results with this information. In this presentation we will describe design, implementation and preliminary evaluation results of our solution called StaDynA.
Estimating sparse models from multivariate discrete data via transformed Lasso

The type of ℓ1 norm regularization used in Lasso and related methods typically yields sparse parameter estimates where most of the estimates are equal to zero. We study a class of estimators obtained by applying a linear transformation on the parameter vector before evaluating the ℓ1 norm. The resulting “transformed Lasso” yields estimates that are “smooth” in a way that depends on the applied transformation. The optimization problem is convex and can be solved efficiently using existing tools. We present two examples: the Haar transform which corresponds to variable length Markov chain (context-tree) models, and the Walsh-Hadamard transform which corresponds to linear combinations of XOR (parity) functions of binary input features.
Bisphenol A and Bisphenol S Induce Distinct Transcriptional Profiles in Differentiating Human Primary Preadipocytes

Bisphenol S (BPS) is increasingly used as a replacement plasticizer for bisphenol A (BPA) but its effects on human health have not been thoroughly examined. Recent evidence indicates that both BPA and BPS induce adipogenesis, although the mechanisms leading to this effect are unclear. In an effort to identify common and distinct mechanisms of action in inducing adipogenesis, transcriptional profiles of differentiating human preadipocytes exposed to BPA or BPS were compared. Human subcutaneous primary preadipocytes were differentiated in the presence of either 25 μM BPA or BPS for 2 and 4 days. Poly-A RNA-sequencing was used to identify differentially expressed genes (DEGs). Functional analysis of DEGs was undertaken in Ingenuity Pathway Analysis. BPA-treatment resulted in 472 and 176 DEGs on days 2 and 4, respectively, affecting pathways such as liver X receptor (LXR)/retinoid X receptor (RXR) activation, hepatic fibrosis and cholestasis. BPS-treatment resulted in 195 and 51 DEGs on days 2 and 4, respectively, revealing enrichment of genes associated with adipogenesis and lipid metabolism including the adipogenesis pathway and cholesterol biosynthesis. Interestingly, the transcription repressor N-CoR was identified as a negative upstream regulator in both BPA- and BPS-treated cells. This study presents the first comparison of BPA- and BPS-induced transcriptional profiles in human differentiating preadipocytes. While we previously showed that BPA and BPS both induce adipogenesis, the results from this study show that BPS affects adipose specific transcriptional changes earlier than BPA, and alters the expression of genes specifically related to adipogenesis and lipid metabolism. The findings provide insight into potential BPS and BPA-mediated mechanisms of action in inducing adipogenesis in human primary preadipocytes.
Facilitating Access to Emotions: Neural Signature of EMDR Stimulation

Background Eye Movement Desensitisation and Reprocessing (EMDR) is a method in psychotherapy effective in treating symptoms of posttraumatic stress disorder. The client attends to alternating bilateral visual, auditory or sensory stimulation while confronted with emotionally disturbing material. It is thought that the bilateral stimulation as a specific element of EMDR facilitates accessing and processing of negative material while presumably creating new associative links. We hypothesized that the putatively facilitated access should be reflected in increased activation of the amygdala upon bilateral EMDR stimulation even in healthy subjects. Methods We investigated 22 healthy female university students (mean 23.5 years) with fMRI. Subjects were scanned while confronted with blocks of disgusting and neutral picture stimuli. One third of the blocks was presented without any additional stimulation, one third with bilateral simultaneous auditory stimulation, and one third with bilateral alternating auditory stimulation as used in EMDR. Results Contrasting disgusting vs. neutral picture stimuli confirmed the expected robust effect of amygdala activation for all auditory stimulation conditions. The interaction analysis with the type of auditory stimulation revealed a specific increase in activation of the right amygdala for the bilateral alternating auditory stimulation. Activation of the left dorsolateral prefrontal cortex showed the opposite effect with decreased activation. Conclusions We demonstrate first time evidence for a putative neurobiological basis of the bilateral alternating stimulation as used in the EMDR method. The increase in limbic processing along with decreased frontal activation is in line with theoretical models of how bilateral alternating stimulation could help with therapeutic reintegration of information, and present findings may pave the way for future research on EMDR in the context of posttraumatic stress disorder.
Absorption measurements of cell monolayers relevant to mechanisms of laser phototherapy: reduction or oxidation of cytochrome c oxidase under laser radiation at 632.8 nm.

OBJECTIVE The objective of this work was a further investigation of redox mechanisms of laser phototherapy on the cellular level. BACKGROUND DATA Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, is believed to work as the photoacceptor to modulate cellular metabolism in laser phototherapy. MATERIALS AND METHODS The changes in the absorption spectra of HeLa-cell monolayers before and after irradiation at 632.8 nm using fast multi-channel recording were evaluated by the intensity ratio between the peaks at 770 and 670 nm (intensity ratio criterion). RESULTS By the intensity ratio criterion, the irradiation effects (reduction or oxidation of the photoacceptor) depended on the initial redox status of cytochrome c oxidase. The irradiation (three times at 632.8 nm, dose = 6.3 x 103 J/m(2), tau(irrad.) = 10 sec, tau(record.) = 600 msec) of cells initially characterized by relatively oxidized cytochrome c oxidase caused first a reduction of the photoacceptor, and then its oxidation (a bell-shaped curve). The irradiation by the same scheme of the cells with initially relatively reduced cytochrome c oxidase caused first oxidation and then a slight reduction of the enzyme (a curve opposite to the bell-shaped curve). CONCLUSION The experimental results of our work demonstrate that irradiation at 632.8 nm causes either a (transient) relative reduction of the photoacceptor, putatively cytochrome c oxidase, or its (transient) relative oxidation, depending on the initial redox status of the photoacceptor. The maximum in the bell-shaped dose-dependence curve or the minimum of the reverse curve is the turning point between the prevailing of oxidation or reduction processes. Our results are evidence that the bell-shaped dose dependences recorded for various cellular responses are characteristic also for redox changes in the photoacceptor, cytochrome c oxidase.
Finding, evaluating, and managing drug‐related risks: approaches taken by the US Food and Drug Administration (FDA)

Marketed pharmaceuticals are evaluated for safety by the US Food and Drug Administration (FDA) throughout the life cycle of the products. The FDA uses data from controlled clinical trials, from postmarketing case reports reported to the FDA's Adverse Event Reporting System, from epidemiological studies, and from registries to evaluate the safety of approved products. For some products, including some products used in dermatologic medicine, risks become apparent during the postmarketing period that require additional measures beyond product labeling and routine pharmacovigilance. The FDA continues to seek additional tools to assess risk, including pharmacogenomic biomarkers for adverse drug reactions and the use of large medical record and epidemiological databases for the systematic detection and characterization of drug‐associated safety outcomes.