Miracle-dz/UniFAR-FTUs huggingface dataset:
The MONIC Framework for Cluster Transition Detection ∗

There is much recent work on detecting and tracking changes in clusters, often based on the study of their spatiotemporal properties. For the many applications where cluster change is relevant, among them customer relationship management, fraud detection and marketing, it is also necessary to provide insights about the nature of change: Is a cluster corresponding to a group of customers simply disappearing or are its members migrating to other clusters? Is a new emerging cluster reflecting a new target group of customers or does it rather consist of existing customers whose preferences shift? To answer such questions, we propose the MONIC framework for modelling and tracking of cluster transitions. Our cluster transition model encompasses changes that involve more than one cluster, thus allowing for insights on cluster change in the whole clustering. Our transition tracking mechanism is not based on the topological properties of clusters, which are only available for some types of clustering, but on the contents of the underlying data stream. We present our first results on monitoring cluster transitions over the ACM digital library.
Poissons ensemble of loops of one-dimensional diffusions

We study the analogue of Poisson ensembles of Markov loops ('loop soups') in the setting of one-dimensional diffusions. We give a detailed description of the corresponding intensity measure. The properties of this measure on loops lead us to an extension of Vervaat's bridge-to-excursion transformation that relates the bridges conditioned by their minimum and the excursions of all the diffusion we consider and not just the Brownian motion. Further we describe the Poisson point process of loops, their occupation fields and explain how to sample these Poisson ensembles of loops using two-dimensional Markov processes. Finally we introduce a couple of interwoven determinantal point processes on the line which is a dual through Wilson's algorithm of Poisson ensembles of loops and study the properties of these determinantal point processes.
A further study on an optical watermarking scheme

Recently, authentication of valuable documents has been widely studied and applied all over the world. One of the solutions for high-security authentication is optical watermark, which is different from traditional digital watermark in the way of watermark extraction. Optical watermark is detected by some optical and visual means. This paper discuss the optical watermark based on Moire phenomenon. We first elucidate the Moire phenomenon mathematically. Then we give an in-depth exploration of optical watermark based on phase modulation in a theoretical way. In addition, a security improvement with random noise is introduced to make the watermark harder to be cracked.
Personalized Web Service Recommendation via Normal Recovery Collaborative Filtering

With the increasing amount of web services on the Internet, personalized web service selection and recommendation are becoming more and more important. In this paper, we present a new similarity measure for web service similarity computation and propose a novel collaborative filtering approach, called normal recovery collaborative filtering, for personalized web service recommendation. To evaluate the web service recommendation performance of our approach, we conduct large-scale real-world experiments, involving 5,825 real-world web services in 73 countries and 339 service users in 30 countries. To the best of our knowledge, our experiment is the largest scale experiment in the field of service computing, improving over the previous record by a factor of 100. The experimental results show that our approach achieves better accuracy than other competing approaches.
Back to the Future with Keynes *

This article analyzes Keynes’s “Economic Possibilities for our Grandchildren”—an essay presenting Keynes’s views about economic growth into the 21st century—from the perspective of modern growth theory. I fi nd that the implicit theoretical framework used by Keynes to form his expectations about the 21st-century world economy is remarkably close to modern growth models, featuring a stable steady-state growth path driven by technological progress. On the other hand, Keynes’s forecast of employment in the 21st century is far off the mark, refl ecting a mistaken view that the income elasticity of leisure is much higher than that of consumption. The views expressed herein are those of the authors and not necessarily those of the Federal Reserve Bank of Minneapolis or the Federal Reserve System. FEDERAL RESERVE BANK OF MINNEAPOLIS
The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome.

WHIM syndrome is a rare congenital immunodeficiency disorder characterized by warts, hypogammaglobulinemia, infections, and myelokathexis (neutropenia because of impaired egress from the BM); most patients also have severe panleukopenia. Because WHIM syndrome is caused by mutations in the chemokine receptor CXCR4 that result in increased agonist-dependent signaling, we hypothesized that the CXCR4 antagonist plerixafor (Mozobil [Genyzme Corporation], AMD3100), might be an effective treatment. To test this, we enrolled 3 unrelated adult patients with the most common WHIM mutation, CXCR4(R334X), in a phase 1 dose-escalation study. Plerixafor increased absolute lymphocyte, monocyte, and neutrophil counts in blood to normal without significant side effects in all 3 patients. Peak responses occurred at 3-12 hours after injection and waned by 24 hours after injection which tracked the drug's pharmacokinetics. All 3 cell types increased in a dose-dependent manner with the rank order of responsiveness absolute lymphocyte > monocyte > neutrophil. These data provide the first pharmacologic evidence that panleukopenia in WHIM syndrome is caused by CXCL12-CXCR4 signaling-dependent leukocyte sequestration, and support continued study of plerixafor as mechanism-based therapy in this disease. This study is registered at http://www.clinicaltrials. gov as NCT00967785.
Qualitative Research and Information Systems Design - Critical reflections from an eHealth Case study

Academic and business environments increasingly accept the utility of diverse qualitative research approaches for informing the design, implementation and evaluation of information systems. However, there are concerns that inherent techno-centrism within the IS discipline distorts criteria for choosing and adapting approaches and, significantly, works to marginalise the opportunities qualitative insights provide to open up human-centered dialogue on new ways of thinking and designing (Gasson 2003). This paper presents a qualitative research approach designed to facilitate critical reflection and sensitise researchers’ to implicit assumptions that technology will be the end-point of their activities and when judgments about criteria for successful designs are technologically and/or economically over-determined. The method endpoint is a conceptual framework constructed for the research domain which is the basis for translating sociological insights into implications for information systems and work practice in a public health service organisation.
Short-circuit-path and floating-node verification of analog circuits in power-down mode

In this work, a method for aging-aware verification of analog circuits in power-down mode is presented. The core of the method is a voltage propagation algorithm that estimates node voltages based on circuit structure only. No numerical simulation is needed. This is crucial as simulation models are often unreliable in power-down mode. A precise graph-based formulation of the voltage propagation algorithm is given. Complexity analysis shows that the propagation algorithm has quadratic complexity. Experimental results show the efficacy and efficiency of the method.
Rhythm Extraction from Polyphony Symbolic Music

We focus on the rhythmic component of symbolic music similarity, proposing several ways to extract a monophonic rhythmic signature from a symbolic poly- phonic score. To go beyond the simple extraction of all time intervals between onsets (noteson extraction), we select notes according to their length (short and long extractions) or their intensities (intensity+/− extractions). Once the rhythm is extracted, we use dynamic programming to compare several sequences. We report results of analysis on the size of rhythm patterns that are specific to a unique piece, as well as experiments on similarity queries (ragtime music and Bach chorale variations). These results show that long and intensity+ extractions are often good choices for rhythm extraction. Our conclusions are that, even from polyphonic symbolic music, rhythm alone can be enough to identify a piece or to perform pertinent music similarity queries, especially when using wise rhythm extractions.
Breastfeeding and Postpartum Depression: An Overview and Methodological Recommendations for Future Research

Emerging research suggests that a relationship exists between breastfeeding and postpartum depression; however, the direction and precise nature of this relationship are not yet clear. The purpose of this paper is to provide an overview of the relationship between breastfeeding and postpartum depression as it has been examined in the empirical literature. Also, the potential mechanisms of action that have been implicated in this relationship are also explored. PubMed and PsycINFO were searched using the keywords: breastfeeding with postpartum depression, perinatal depression, postnatal depression. Results of this search showed that researchers have examined this relationship in diverse ways using diverse methodology. In particular, researchers have examined the relationships between postpartum depression and breastfeeding intention, initiation, duration, and dose. Due to a number of methodological differences among past studies we make some recommendations for future research that will better facilitate an integration of findings. Future research should (1) use standardized assessment protocols; (2) confirm diagnosis through established clinical interview when possible; (3) provide a clear operationalized definition for breastfeeding variables; (4) clearly define the postpartum period interval assessed and time frame for onset of symptoms; (5) be prospective or longitudinal in nature; and (6) take into consideration other potential risk factors identified in the empirical literature.
Teaching Entrepreneurship through E-learning: The Implementation in Schools of Social Sciences and Humanities in Greece

In a constantly changing environment young people in Greece face the dilemma to search for career opportunities abroad, or to work in Greek private or public sector. Since unemployment is growing and the labor market gets more pretentious, people obtain more diplomas to become more competitive and appropriate for market’s needs. Additionally, job providers claim that they cannot find workforce with real knowledge on organization needs (“skills gap” phenomenon). This knowledge is a privilege of business or economic schools. On the other hand Social and Humanities Schools do not provide such courses so it becomes more difficult for their graduates to be absorbed by the labor market. In order to maintain university’s curriculum and provide students with further practical skills, e-learning as a supplementary tool could be an aid for those who want to start their own business or for those who aim to be the future, competitive workforce.
The Chaperone TRAP1 As a Modulator of the Mitochondrial Adaptations in Cancer Cells

Mitochondria can receive, integrate, and transmit a variety of signals to shape many biochemical activities of the cell. In the process of tumor onset and growth, mitochondria contribute to the capability of cells of escaping death insults, handling changes in ROS levels, rewiring metabolism, and reprograming gene expression. Therefore, mitochondria can tune the bioenergetic and anabolic needs of neoplastic cells in a rapid and flexible way, and these adaptations are required for cell survival and proliferation in the fluctuating environment of a rapidly growing tumor mass. The molecular bases of pro-neoplastic mitochondrial adaptations are complex and only partially understood. Recently, the mitochondrial molecular chaperone TRAP1 (tumor necrosis factor receptor associated protein 1) was identified as a key regulator of mitochondrial bioenergetics in tumor cells, with a profound impact on neoplastic growth. In this review, we analyze these findings and discuss the possibility that targeting TRAP1 constitutes a new antitumor approach.
PEER-TO-PEER SYSTEMS

In this paper, a new approach for data fusion in the context of schema-based Peer-To-Peer (P2P) systems is proposed. Schema-based systems manage and provide query capabilities for (semi-)structured information: queries have to be formulated in terms of schema. Schema-based P2P are called Peer Data Management system (PDMS). A challenging problem in a schema-based peerto-peer (P2P) system is how to locate peers who have data relevant to a given query. Our proposal lies in application of the multi-data source fusion approach in the context of PDMS. Multi-data source schemas, distributed, shared and maintained by peers, are the basis of a semantic overlay network. The semantic overlay network and the power of Multi-data source Fusion Language (MFL) are exploited for efficient query routing towards the relevant peers. We show the design of the Peer Multi-Data source Management System (PMDMS) and we focus on the Matchmaker and routing components. We give a performance evaluation of the semantic query routing with respect to important criteria such as precision, recall, response time and number of messages. We give a performance evaluation of the semantic reconciliation between peers. We compare this result with other systems developed according to peer/super-peer approach. Finally, we show a prototype developed according to PMDMS. We build an application that shares, data between peers, in the domain of leisure such as, bank, cinema, restaurant, etc.
Paeoniflorin and Albiflorin Attenuate Neuropathic Pain via MAPK Pathway in Chronic Constriction Injury Rats

Neuropathic pain remains as the most frequent cause of suffering and disability around the world. The isomers paeoniflorin (PF) and albiflorin (AF) are major constituents extracted from the roots of Paeonia (P.) lactiflora Pall. Neuroprotective effect of PF has been demonstrated in animal models of neuropathologies. However, only a few studies are related to the biological activities of AF and no report has been published on analgesic properties of AF about neuropathic pain to date. The aim of this study was to compare the effects of AF and PF against CCI-induced neuropathic pain in rat and explore the underlying mechanism. We had found that both PF and AF could inhibit the activation of p38 mitogen-activated protein kinase (p38 MAPK) pathway in spinal microglia and subsequent upregulated proinflammatory cytokines (interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α)). AF further displayed remarkable effects on inhibiting the activation of astrocytes, suppressing the overelevated expression of phosphorylation of c-Jun N-terminal kinases (p-JNK) in astrocytes, and decreasing the content of chemokine CXCL1 in the spinal cord. These results suggest that both PF and AF are potential therapeutic agents for neuropathic pain, which merit further investigation.
The prevalence and persistence of sigma virus, a biparentally transmitted parasite of Drosophila melanogaster.

QUESTION How do vertically transmitted parasites persist? ORGANISMS Drosophila melanogaster (host) and sigma virus (parasite). FIELD SITE Peach stands in northern Georgia, USA, on a transect between Macon and Athens. EMPIRICAL METHODS We estimated prevalence in the field. We also estimated male and female transmission in the laboratory, using field-collected animals as parents. We further quantified patrilineal (father to son) transmission in the laboratory, and estimated cost of infection (virulence) by quantifying decreased egg production of infected flies. MATHEMATICAL METHODS Discrete-time, deterministic models for prevalence; analysis of stability of disease-free and endemic equilibria; numerical computation of equilibria based on empirical estimates. KEY ASSUMPTIONS Random mating, discrete generations, cost of infection to females only. PREDICTIONS AND CONCLUSIONS The model allows persistence under parameter estimates obtained for this population. Uncertainty in parameters leads to wide confidence intervals on the predicted prevalence, which may be systematically underestimated due to Jensen's inequality. Male transmission is required for persistence, and multiple generations of strictly patrilineal transmission are possible in the laboratory, albeit with decreasing transmission efficiency.
HILLARY CLINTON AND THE WOMEN WHO SUPPORTED HER

Abstract Using data from the 2008 American National Election Studies (ANES) time series, and the 2008 ANES panel wave, this study examines whether the intragroup emotions Hillary Clinton elicits—gender affinity and pride—are predictive of political engagement for the group she represents: women voters. We focus on voters who report having participated in the primaries and the range of potential voters who proselytize during the primary season and express an intention to vote in the general election. Contrary to the conclusion one might reasonably draw—that is, women rather than men would be more likely to support Clinton—the real question is: which women?
Odor-Evoked Oxygen Consumption by Action Potential and Synaptic Transmission in the Olfactory Bulb

The relationship between metabolism of neuronal activity, microvascular organization, and blood flow dynamics is critical for interpreting functional brain imaging. Here we used the rat dorsal olfactory bulb as a model to determine in vivo the correlation between action potential propagation, synaptic transmission, oxygen consumption, and capillary density during odor stimulation. We find that capillary lumen occupies ∼3% of the glomerular volume, where synaptic transmission occurs, and only 0.1% of the overlying nerve layer. In glomeruli, odor triggers a local early decrease in tissue oxygen partial pressure that results principally from dendritic activation rather than from firing of axon terminals, transmitter release or astrocyte activation. In the nerve layer, action potential propagation does not generate local changes in tissue oxygen partial pressure. We conclude that capillary density is tightly correlated with the oxidative metabolism of synaptic transmission, and suggest that action potential propagation operates mainly anaerobically.
Gamma-secretase Inhibitor Prevents Proliferation and Migration of Ductus Arteriosus Smooth Muscle Cells through the Notch3-HES1/2/5 Pathway

Patent ductus arteriosus (PDA) can cause morbidity and mortality in neonates. Vascular remodeling, characterized by proliferation and migration of smooth muscle cells (SMCs), is an essential process for postnatal DA closure. Notch signaling is an important mediator of vascular remodelling but its role in DA is unkonwn. We investigated the effects and underlying mechanisms of γ-secretase inhibitor DAPT, a Notch signaling inhibitor on angiotensin II (Ang II)-induced proliferation and migration of DASMCs. Proliferation and migration of DASMCs cultured from neonatal Wistar rats were induced by Ang II, with or without DAPT pre-treatment. In addition, potential underlying mechanisms including cell cycle progression, Ca2+ influx, reactive oxygen species (ROS) production, signal transduction of MAPK and Akt, and Notch receptor with its target gene pathway were examined. We found that DAPT inhibited Ang II-induced DASMCs proliferation and migration dose dependently. DAPT also arrested the cell cycle progression in the G0/G1-phase, and attenuated calcium overload and ROS production caused by Ang II. Moreover, DAPT inhibited nuclear translocation of Notch3 receptor intracellular domain, with decreased expression of its down-stream genes including HES1, HES2 and HES5. Finally, Ang II-activated ERK1/2, JNK and Akt were also counteracted by DAPT. In conclusion, DAPT inhibits Ang II-induced DASMCs proliferation and migration. These effects are potentially mediated by decreased calcium influx, reduced ROS production, and down-regulation of ERK1/2, JNK and Akt, through the Notch3-HES1/2/5 pathway. Therefore, Notch signaling has a role in DA remodeling and may provide a target pathway for therapeutic intervention of PDA.
Random correlations for small perturbations of expanding maps

We consider random compositions F n ! F ! of C k expanding maps F ! which are C k-close to a given C k expanding map (k > 1) and not necessarily i.i. d. We study the random correlation functions C ! (n) associated to the unique absolutely continuous stationary measures F ! = ! and smooth test functions. We show C k? 1 stability of the densities of the measures ! , and good uniform bounds on the exponential rate of decay of random correlations as the smooth error level goes to zero. To do this, we let the associated random transfer operators L F ! act on suitable cones of positive functions endowed with a Hilbert projective metric.
A Gale-Shapley algorithm for allocation of relayed parallel wiretap coding channels

Alice aims at transmitting Bob a message to be kept secret from Eve, with the assistance of relays operating in a decode-and-forward fashion. Each link between node couples comprises a set of parallel channels. Both Alice and relays knows all legitimate channel gains, while they only have a statistical knowledge of the channels to Eve. By fixing a secrecy outage probability per channel, we optimize power and rate of the messages sent by Alice to the relays (phase one) and from the relays to Bob (phase two), in order to maximize the achievable end-to-end outage secrecy rate. Since the phase-one rate cannot exceed the phase-two rate for each relay, the allocations in the two phases are tightly coupled, making the optimization quite challenging. Therefore we propose a solution based on the Gale-Shapley approach to the stable matching problem. The algorithm iterates between two stages, one in which each relay proposes Bob a secret rate on a specific channel, and another in which Bob discards the offer providing the lowest rate. The process is repeated until a single offer is available on each channel. Offers by the relays are based on (and in turns influence) the resource allocation by Alice with respect to her transmission to the relays. Numerical results are provided, showing the merit of the proposed solution with respect to existing approaches.