Miracle-dz/UniFAR-FTUs huggingface dataset:
Ibogaine Signals Addiction Genes and Methamphetamine Alteration of Long‐Term Potentiation

Abstract: The mapping of the human genetic code will enable us to identify potential gene products involved in human addictions and diseases that have hereditary components. Thus, large‐scale, parallel gene‐expression studies, made possible by advances in microarray technologies, have shown insights into the connection between specific genes, or sets of genes, and human diseases. The compulsive use of addictive substances despite adverse consequences continues to affect society, and the science underlying these addictions in general is intensively studied. Pharmacological treatment of drug and alcohol addiction has largely been disappointing, and new therapeutic targets and hypotheses are needed. As the usefulness of the pharmacotherapy of addiction has been limited, an emerging potential, yet controversial, therapeutic agent is the natural alkaloid ibogaine. We have continued to investigate programs of gene expression and the putative signaling molecules used by psychostimulants such as amphetamine in in vivo and in vitro models. Our work and that of others reveal that complex but defined signal transduction pathways are associated with psychostimulant administration and that there is broad‐spectrum regulation of these signals by ibogaine. We report that the actions of methamphetamine were similar to those of cocaine, including the propensity to alter long‐term potentiation (LTP) in the hippocampus of the rat brain. This action suggests that there may be a “threshold” beyond which the excessive brain stimulation that probably occurs with compulsive psychostimulant use results in the occlusion of LTP. The influence of ibogaine on immediate early genes (IEGs) and other candidate genes possibly regulated by psychostimulants and other abused substances requires further evaluation in compulsive use, reward, relapse, tolerance, craving and withdrawal reactions. It is therefore tempting to suggest that ibogaine signals addiction gene products.
MULTI-USER MIMO DOWNLINK PRECODING FOR TIME-VARIANT CORRELATED CHANNELS

Multi-user multiple-input multiple-output (MU-MIMO) systems provide a significantly increased capacity and spectra l efficiency by exploiting the benefits of space division multi ple access (SDMA). The channel state information (CSI) at the base station (BS) is used to precode the transmit signals and to simplify the processing at the users’ terminals. If perfe ct CSI is available at the transmitter, the multi-user interfe rence (MUI) can be effectively eliminated at the BS. If the channel varies too fast to obtain short-term CSI, long-term CSI can be used alternatively to improve the system performance. In this paper we propose a new approach to multi-user precoding based on long-term CSI, which can be applied to previously defined precoding techniques originally requiring perfect CSI at the BS. It is shown that a significant performance improvement is achieved by the new approach as compared to a state of the art approach [1] to multi-user precoding with long-term CSI, especially for the case when a user has a line of sight (LOS) channel.
Cervical metastasis on level IV in laryngeal cancer

SUMMARY The presence of cervical metastasis has substantial negative impact on survival of patients with laryngeal cancer. Bilateral elective selective neck dissection of levels II, III and IV is usually the chosen approach in these patients. However, there is significant morbidity associated with level IV dissection, such as phrenic nerve injury and lymphatic fistula. The objective of the present study was to evaluate the frequency of metastatic nodes in level IV in clinically T3/T4N0 patients with laryngeal cancer. The pathological reports of 77 patients with clinically T3/T4N0 laryngeal squamous cell carcinoma were reviewed. Patients underwent bilateral lateral neck dissection from January 2007 to November 2012. The surgical specimens were subdivided in levels before evaluation. There were 12 patients with neck metastasis (15.58%). In 3 cases (3.89%), there were metastatic lymph nodes in level IV, all T4 and with ipsilateral metastasis. In conclusion, the incidence of level IV metastasis was 3.89%, an in all patients was staged as T4.
Design of Aperture-Coupled Microstrip Antenna for HIPERLAN/2 using Differential Algorithm

In this paper, design of an aperture-coupled microstrip antenna (ACMSA) using differential evolution algorithm (DE) is described. The classical transmission line model for microstrip antenna is used to determine fitness function for DE and computed results are compared with the results obtained using particle swarm optimization (PSO) and binary coded genetic algorithm (GA). The aperture-coupled microstrip antenna is fabricated and measured results are compared with the results obtained using differential evolution algorithm.
Apraxia of speech: how reliable are speech and language therapists' diagnoses?

Objective : To discover how reliably speech and language therapists could diagnose apraxia of speech using their clinical judgement, by measuring whether they were consistent (intra-rater reliability), and whether their diagnoses agreed (inter-rater reliability). Design : Video clips of people with communication difficulties following stroke were rated by four speech and language therapists who were given no definition of apraxia of speech, no training, and no opportunity for conferring. Settings : Videos were made of people following stroke in their homes. Ratings of the videos were carried out in the university lab under controlled conditions. Subjects : Forty-two people with communication difficulties such as aphasia, apraxia of speech and dysarthria took part, and four specialist speech and language therapists acted as raters. Main measure : Speech and language therapists' ratings of the presence and severity of apraxia of speech using videos. Results : Intra-rater reliability was high for diagnosing (1) the presence of apraxia of speech (Cohen's kappas ranging from 0.90 to 1.00; 0.93 overall), and (2) the severity of apraxia of speech (kappa 0.84 to 0.92; 0.90 overall). The inter-rater reliability was also high for both the presence of apraxia of speech (kappa 0.86) and severity of apraxia of speech (0.74). Conclusion : Despite controversy over its nature and existence, specialist speech and language therapists show high levels of agreement on the diagnosis of apraxia of speech using their clinical judgement.
Single-image splicing localization through autoencoder-based anomaly detection

We propose a new method for single-image splicing localization. Lacking any side information, such as training data or prior knowledge on the source camera and the image history, we cast the problem as an anomaly detection task. Expressive local features, extracted from the noise residual of the image, feed an autoencoder which generates an implicit model of the data. By iterating discriminative feature labeling and autoencoding, the implicit model fits eventually the pristine data, while the spliced region is recognized as anomalous. Experiments on a suitable test set of spliced images show that the proposed method outperforms the previous state-of-the-art. In addition, it exhibits a good robustness against typical social net post-processing, showing promises for real-world applications.
Candidate selection in local politics in French-speaking Belgium

Candidate selection in local politics in French-speaking Belgium Jean-Benoit Pilet, Nicolas De Decker, Régis Dandoy and Pascal Delwit Cevipol, Université Libre de Bruxelles (U.L.B.), Belgium jpilet@ulb.ac. be ndedecke@ulb.ac. be Jean-Benoit Pilet is post-doctoral researcher FNRS in political science and lecturer at the Université Libre de Bruxelles Nicolas De Decker is research and teaching assistant at the Université Libre de Bruxelles. Régis Dandoy is research and teaching assistant at the Université Libre de Bruxelles. Pascal Delwit is Professor in political science at the Université Libre de Bruxelles.
Sex differences in obstructive sleep apnoea in an elderly French population

Obstructive sleep apnoea (OSA) affects females and males differently, and increases in prevalence with age. The aim of the present study was to characterise clinical, anthropometric and polygraphic sex differences in a large elderly OSA population. A total of 641 subjects aged 68 yrs were examined. Measurements of fat mass, using dual-energy X-ray absorptiometry (DEXA) and polygraphy, were obtained in all subjects. An apnoea/hypopnoea index (AHI) of >15 events·h−1 identified the presence of OSA. OSA was diagnosed in 57% of the sample, 34% having a mild form and 23% having an AHI of >30 events·h−1. Females with OSA exhibited a lower AHI, less severe hypoxaemia and greater peripheral fat mass, and frequently reported anxiety and depression. Comparison of females with and without OSA did not reveal significant differences in clinical, anthropometric and DEXA data. After adjustment for body mass index, hypertension, diabetes, smoking, anxiety and depression, logistic regression analysis revealed that the presence of hypertension was significantly associated with OSA risk in females (OR 1.52, p = 0.04). In a general community healthy population, the prevalence of undiagnosed OSA in females increases with age, with a risk similar to that in males. In females, the clinical spectrum, anthropometric data and fat distribution appear to be more sex-related than OSA-dependent. The occurrence of OSA contributes to hypertensive risk in elderly females.
The Genus Spilanthes Ethnopharmacology, Phytochemistry, and Pharmacological Properties: A Review

Spilanthes spp. are popular, over-the-counter remedies; they are sold over the internet under various names and are widely used in traditional medicine in various cultures. This review will summarize the important reports on the ethnopharmacology, botany, phytochemistry, and pharmacological properties as described in the literature from recent years (1920 to 2013). Spilanthes spp. are used for more than 60 types of disorders. They are reported to contain a number of biologically active phytochemicals, although a large number of ethnopharmacological uses have been documented; only a few of these species have been investigated for their chemical and biological activities. The studies are carried out mainly on Spilanthes extracts and a few metabolites substantiate the uses of these plants in traditional medicine. Well-conducted pharmacological studies are still needed for several traditional indications, and the mechanisms of action by which the plant extracts and the active compounds exert their pharmacological effects remain to be studied. They are predominantly used as extracts in personal care products, traditional medicines, and the pharmaceutical and culinary areas. Suggestions are made regarding some of the possible mechanisms of action as to how the known compounds may exert their biological activity.
SAGA functions probed by genome-wide synthetic genetic array ( SGA ) analysis using a Saccharomyces cerevisiae taf 9-ts allele

# These authors contributed equally to this work. ABSTRACT TAF9 is a TATA binding protein associated factor (TAF) conserved from yeast to humans, and shared by two transcription coactivator complexes, TFIID and SAGA. The essentiality of the TAFs has made it difficult to ascertain their roles in TFIID and SAGA function. Here, we performed a genomic synthetic genetic array analysis using a temperature sensitive allele of TAF9 as a query. Results from this experiment showed that TAF9 interacts genetically with: 1) genes for multiple transcription factor complexes involving predominantly Mediator, chromatin modification/remodeling complexes, and regulators of transcription elongation; 2) virtually all non-essential genes encoding subunits of the SWR-C chromatin-remodeling complex, and both TAF9 and SWR-C are required for expressing the essential housekeeping gene RPS5; 3) key genes for cell cycle control at the G1/S transition, as well as genes involved in cell polarity, cell integrity, and protein synthesis, suggesting a link between TAF9 function and cell growth control. We also showed that disruption of SAGA by deletion of SPT20 alters histone-DNA contacts and phosphorylated forms of RNA polymerase II at coding sequences. Our results raise the possibility of an unappreciated role for TAF9 in transcription elongation, perhaps in the context of SAGA, and provide further support for TAF9 involvement in cell cycle progression and growth control.
A Complete Axiom System for Propositional Interval Temporal Logic with Infinite Time

Interval Temporal Logic (ITL) is an established temporal formalism for reasoning about time periods. For over 25 years, it has been applied in a number of ways and several ITL variants, axiom systems and tools have been investigated. We solve the longstanding open problem of finding a complete axiom system for basic quantifier-free propositional ITL (PITL) with infinite time for analysing nonterminating computational systems. Our completeness proof uses a reduction to completeness for PITL with finite time and conventional propositional linear-time temporal logic. Unlike completeness proofs of equally expressive logics with nonelementary computational complexity, our semantic approach does not use tableaux, subformula closures or explicit deductions involving encodings of omega automata and nontrivial techniques for complementing them. We believe that our result also provides evidence of the naturalness of interval-based reasoning.
Towards a geometric interpretation of double-cross matrix-based similarity of polylines

One of the formalisms to qualitatively describe polylines in the plane are double-cross matrices. In a double-cross matrix the relative position of any two line segments in a polyline is described with respect to a double cross based on their start points. Two polylines are called DC-similar if their double-cross matrices are identical. Although double-cross matrices have been widely applied, a geometric interpretation of the similarity they express is still lacking. In this paper, we provide a first step in the geometric interpretation of this qualitative definition of similarity. In particular, we give an effective characterization of what DC-similarity means for polylines that are drawn on a grid. We also provide algorithms that, given a DC-matrix, check whether it is realizable by a polyline on a grid and that construct, if possible, in quadratic time example polylines that satisfy this matrix. We also describe algorithms to reconstruct polylines, satisfying a given double-cross matrix, in the two-dimensional plane, that is, not necessarily on a grid.
Comparison of the Extended and Sigma-point Kalman Filters on Inertial Sensor Bias Estimation Through Tight Integration of GPS and INS

Yong Li is a Research Associate at the School of Surveying & Spatial Information Systems, the University of New South Wales (UNSW), Sydney, Australia. Yong obtained a Doctor of Philosophy in flight dynamics from the Northwestern Polytechnical University, China. He was working on GPS aerospace applications, first at the Beijing Institute of Control Engineering and then the Japanese Aerospace Exploration Agency (JAXA, formerly the National Aerospace Laboratory), and on a GPS sports application at the RMIT University, Australia. His current research interests include integration of GPS and INS, attitude determination, software GPS receivers, and optimal estimation/filtering theory and applications.
Improvement of Conversation Skills through Script Fading in a Child with Autism Spectrum Disorder

The script fading procedure aims to develop better communication skills of children and youngsters with Autism Spectrum Disorder in relationship with other people. The procedure seeks to incorporate cues in several contexts. Scripts may be organized in day-to-day situations of life, such as playful interactions among children and the scripts may consist in pictorial, textual or auditory stimuli. If a learner, for example, lacks conversation skills, but has good repertoire regarding textual behavior, scripts consisting of written phrases may be presented and the learner has to read them. The listener may interact with the speaker like he is emitting responses free from the control of scripts. With repetitive exposure to the contingency and the establishment of a more fluent repertoire of textual behavior, the script is gradually faded out by word removal one by one. This process continues until the learner’s responses become free from the control of the whole scripts. Previous research has demonstrated the establishment of independent performance, maintenance and generalization to different settings and listeners. The purpose of this study was to assess the efficacy of this procedure in establishing conversation skills in a child aged 9 with ASD. Textual scripts were applied to three sets of conversation. After a baseline condition, training started and the experimental control by the independent variable was established through a multiple baseline design across the three different conversation topics. Independent performance was successfully established through reinforcement of correct performance and error correction. Although the interventions were conducted in a university-based laboratory, the established repertoires generalized to the child’s school classroom and another listeners (another adult and a child). Implications to school inclusion regarding the establishment of conversation among children in school setting were discussed.
Measuring Semantic Similarity in Short Texts through Greedy Pairing and Word Semantics

We propose in this paper a greedy method to the problem of measuring semantic similarity between short texts. Our method is based on the principle of compositionality which states that the overall meaning of a sentence can be captured by summing up the meaning of its parts, i.e. the meanings of words in our case. Based on this principle, we extend word-to-word semantic similarity metrics to quantify the semantic similarity at sentence level. We report results using several word-to-word semantic similarity metrics, based on word knowledge or vectorial representations of meaning. Our approach performs better than similar approaches on the tasks of paraphrase identification and recognizing textual entailment, which are two illustrative semantic similarity tasks. We also report the role of word weighting and of function words on the performance of the proposed method.
Peristaltic Transport of a Herschel-Bulkley Fluid in a Non-Uniform Channel with Wall Effects

669 Abstract—The present study considers the peristaltic transport of a Herschel-Bulkley fluid in a two-dimensional channel of non-uniform cross section with wall properties. Using long wavelength approximation with low Reynolds number and dynamic boundary conditions, analytical expressions have been obtained stream function and time average velocity. The effects of pertinent parameters on these flow variables have been studied in both converging and diverging channel. It is observed that time average velocity increases with rigidity and stiffness in the wall.
Tn1546 is part of a larger plasmid-encoded genetic unit horizontally disseminated among clonal Enterococcus faecium lineages

Objectives To determine the genetic composition of the first VanA-type plasmid (pIP816) reported, which was isolated from a clinical Enterococcus faecium (BM4147) strain in France in 1986, and to reveal the genetic units responsible for the dissemination of the vanA gene cluster by comparisons with current, published and additionally generated vanA-spanning plasmid sequences obtained from a heterogeneous E. faecium strain collection (n = 28). Methods Plasmid sequences were produced by shotgun sequencing using ABI dye chemistry and primer walking, and were subsequently annotated. Comparative sequence analysis of the vanA region was done with published plasmids, with a partial vanA plasmid (pVEF4) reported here and to >140 kb of sequence obtained from a collection of vanA-harbouring plasmid fragments. Results Bioinformatic analyses revealed that pIP816 from 1986 and contemporary vanA plasmids shared a conserved genetic fragment of 25 kb, spanning the 10.85 kb vanA cluster encoded by Tn1546, and that the larger unit is present in both clinical and animal complexes of E. faecium. A new group II intron in pVEF4 was characterized. Conclusions Comparative DNA analyses suggest that Tn1546 disseminates in and between clonal complexes of E. faecium as part of a larger genetic unit, possibly as a composite transposon flanked by IS1216 elements.
Adenosine A2A Receptors in Psychopharmacology: Modulators of Behavior, Mood and Cognition

The adenosine A2A receptor (A2AR) is in the center of a neuromodulatory network affecting a wide range of neuropsychiatric functions by interacting with and integrating several neurotransmitter systems, especially dopaminergic and glutamatergic neurotransmission. These interactions and integrations occur at multiple levels, including (1) direct receptor- receptor cross-talk at the cell membrane, (2) intracellular second messenger systems, (3) trans-synaptic actions via striatal collaterals or interneurons in the striatum, (4) and interactions at the network level of the basal ganglia. Consequently, A2ARs constitute a novel target to modulate various psychiatric conditions. In the present review we will first summarize the molecular interaction of adenosine receptors with other neurotransmitter systems and then discuss the potential applications of A2AR agonists and antagonists in physiological and pathophysiological conditions, such as psychostimulant action, drug addiction, anxiety, depression, schizophrenia and learning and memory.
Recent Progress in Mathematical Analysis of Vortex Sheets

We consider the motion of the interface separating two domains of the same fluid that moves with different velocity along the tangential direction of the interface. We assume that the fluids occupying the two domains are of constant densities that are equal, are inviscid, incompressible and irrotational, and that the surface tension is zero. We discuss results on the existence and uniqueness of solutions for given data, the regularity of solutions, singularity formation and the nature of solutions after the singularity formation time. 2000 Mathematics Subject Classification: 76B03, 76B07, 76B47, 35Q35, 35J60.
On Broadcast Stability of Queue-Based Dynamic Network Coding Over Erasure Channels

The transmission of packets is considered from one source to multiple receivers over single-hop erasure channels. The objective is to evaluate the stability properties of different transmission schemes with and without network coding. First, the throughput limitation of retransmission schemes is discussed and the stability benefits are shown for randomly coded transmissions, which, however, need not optimize the stable throughput for finite coding field size and finite packet block size. Next, a dynamic scheme is introduced for distributing packets among virtual queues depending on the channel feedback and performing linear network coding based on the instantaneous queue contents. The difference of the maximum stable throughput from the min-cut rate is bounded as function of the order of erasure probabilities depending on the complexity allowed for network coding and queue management. This queue-based network coding scheme can asymptotically optimize the stable throughput to the max-flow min-cut bound, as the erasure probabilities go to zero. This is realized for a finite coding field size without accumulating packet blocks at the source to start network coding. The comparison of random and queue-based dynamic network coding with plain retransmissions opens up new questions regarding the tradeoffs of stable throughput, packet delay, overhead, and complexity.