Miracle-dz/UniFAR-FTUs huggingface dataset:
Liraglutide Improves the Angiogenic Capability of EPC and Promotes Ischemic Angiogenesis in Mice under Diabetic Conditions through an Nrf2-Dependent Mechanism

The impairment in endothelial progenitor cell (EPC) functions results in dysregulation of vascular homeostasis and dysfunction of the endothelium under diabetic conditions. Improving EPC function has been considered as a promising strategy for ameliorating diabetic vascular complications. Liraglutide has been widely used as a therapeutic agent for diabetes. However, the effects and mechanisms of liraglutide on EPC dysfunction remain unclear. The capability of liraglutide in promoting blood perfusion and angiogenesis under diabetic conditions was evaluated in the hind limb ischemia model of diabetic mice. The effect of liraglutide on the angiogenic function of EPC was evaluated by cell scratch recovery assay, tube formation assay, and nitric oxide production. RNA sequencing was performed to assess the underlying mechanisms. Liraglutide enhanced blood perfusion and angiogenesis in the ischemic hindlimb of db/db mice and streptozotocin-induced type 1 diabetic mice. Additionally, liraglutide improved tube formation, cell migration, and nitric oxide production of high glucose (HG)-treated EPC. Assessment of liraglutide target pathways revealed a network of genes involved in antioxidant activity. Further mechanism study showed that liraglutide decreased the production of reactive oxygen species and increased the activity of nuclear factor erythroid 2-related factor 2 (Nrf2). Nrf2 deficiency attenuated the beneficial effects of liraglutide on improving EPC function and promoting ischemic angiogenesis under diabetic conditions. Moreover, liraglutide activates Nrf2 through an AKT/GSK3β/Fyn pathway, and inhibiting this pathway abolished liraglutide-induced Nrf2 activation and EPC function improvement. Overall, these results suggest that Liraglutide represents therapeutic potential in promoting EPC function and ameliorating ischemic angiogenesis under diabetic conditions, and these beneficial effects relied on Nrf2 activation.
Models of Care for Inflammatory Bowel Disease: A National Cross-sectional Survey to Characterize the Landscape of Inflammatory Bowel Disease Care in Canada

Abstract Background Collaborative care models improve inflammatory bowel disease (IBD) patient outcomes, yet little is known about the capacity or available resources to deliver such model of care in Canada. We aimed to describe the structure and process characteristics of clinical care delivery models for IBD across Canada, including the number of collaborative care centers. Methods A cross-sectional study was conducted between November 2017 and October 2018 through an online survey. This survey was distributed to gastroenterologists at community and academic centers across Canada who provide care for IBD patients. Comparisons between collaborative and non-collaborative centers were analyzed using chi-squares or t-tests. Descriptive statistics of respondent demographics were also generated. Results Seventy-two gastroenterologists from 62 unique IBD centers completed the survey. A total of 7 unique collaborative centers and 55 unique non-collaborative centers were identified. There were significant differences between collaborative and non-collaborative centers in some aspects of access to IBD care, patient assessment and referral process, and patent education and empowerment. Notably, very few centers had processes for implementing and evaluating evidence-based clinical pathways, and auditing quality indicators. Conclusions Our findings identify areas for improving the quality of IBD care in Canada. Expanding the number of and access to collaborative care centers in Canada is needed, in addition to increased focus on patient education, communication, and implementation of evidence-based care pathways.
EXPERIMENTAL STUDIES ON AIR-ASSISTED ATOMIZATION OF JATROPHA PURE PLANT OIL

The present study focuses on exploring air-assisted atomization strategies for effective atomization of high-viscosity biofuels, such as pure plant oils (PPOs). The first part of the study concerns application of a novel air-assisted impinging jet atomization for continuous spray applications, and the second part concerns transient spray applications. The particle/droplet imaging analysis (PDIA) technique along with direct imaging methods are used for the purpose of spray characterization. In the first part, effective atomization of Jatropha PPO is demonstrated at gas-to-liquid ratios (GLRs) on the order 0.1. The effect of liquid and gas flow rates on the spray characteristics is evaluated, and results indicate a Sauter mean diameter (SMD) of 50 mu m is achieved with GLRs as low as 0.05. In the second part of the study, a commercially available air-assisted transient atomizer is evaluated using Jatropha PPO. The effect of the pressure difference across the air injector and ambient gas pressure on liquid spray characteristics is studied. The results indicate that it is possible to achieve the same level of atomization of Jatropha as diesel fuel by operating the atomizer at a higher pressure difference. Specifically, a SMD of 44 mu m is obtained for the Jatropha oil using injection pressures of <1 MPa. A further interesting observation associated with this injector is the near constancy of a nondimensional spray penetration rate for the Jatropha oil spray.
Conditional Heteroskedasticity in Nonlinear Simultaneous Equations

We show in this paper that the treatment of conditional heteroskedasticity inside nonlinear systems of simultaneous equations is a sufficiently manageable matter for some types of multivariate ARCH error structures. Reparameterization makes it possible to estimate the model by means of the (nearly) standard algorithms developed in the past and widely used for estimating nonlinear simultaneous equations where the error structure is of the i.i. d. type with unrestricted contemporaneous covariance matrix. The method is discussed in this paper and empirical applications exemplify the efficiency gains.
Compounds in Indonesian Ginger Rhizome Extracts and Their Potential for Anti-Skin Aging Based on Molecular Docking

Skin aging is a condition caused by reactive oxygen species (ROS) and advanced glycation end products (AGEs). Indonesian gingers (Zingiber officinale), which consists of Gajah (GG), Red (MM), and Emprit (EE) ginger, are thought to produce anti-skin aging compounds through enzyme inhibition. The enzymes used in the molecular docking study were collagenase, hyaluronidase, elastase, and tyrosinase. This study aimed to determine the compounds contained in Indonesian ginger rhizome ethanolic extracts using liquid chromatography–mass spectrometry/mass spectrometry to differentiate metabolites contained in the different Indonesian ginger rhizome extracts. A principal component analysis (PCA) and a heat map analysis were used in order to determine which compounds and extracts contained potential anti-skin aging properties based on a molecular docking study. Ascorbic acid was used as a control ligand in the molecular docking study. Ninety-eight compounds were identified in three different ginger rhizomes extracts and were grouped into three separate quadrants. The most potent compound for anti-skin aging in the Indonesian ginger rhizome extracts was octinoxate. Octinoxate showed a high abundance in the EE ginger rhizome extract. Therefore, the EE ginger extract was the Indonesian ginger rhizome extract with the greatest potential for anti-skin aging.
First Report of Acanthocheilonema reconditum Outbreak in Canines with Clinical Signs of Anemia from Southwestern Colombia

Different nematodes affect canines, however Acanthocheilonema reconditum was considered mostly a non-pathogenic parasite. Climate change, animal migration, and other factors transformed the dynamics of vector-borne diseases, including filariasis. Since 2016, a sudden increase in the number of dogs with microfilaremia was reported by different veterinary centers in Cali, southwest Colombia. The objective of this study was to molecularly identify the etiologic agent of this filariasis outbreak detected in this city, using PCR–RFLP and evaluating dogs’ clinical signs. From 2018–2019, canine filariasis cases were prospectively evaluated after a microscopic test, recruiting 82 cases and 43 healthy controls from 2971 samples. Acanthocheilonema reconditum (Nematoda, Onchocercidae) was identified in 61.3% of the cases (49/82) by PCR–RFLP. Sanger sequencing of the 5.8S ribosomal RNA gene and internal transcribed spacer-2 fragment was additionally performed on seven cases, confirming A. reconditum in all of them. The filariasis cases are statistically associated with male dogs who have clinical signs of anemia, low levels of hemoglobin and hematocrit (p < 0.0001), and high levels of plasma proteins (p < 0.001). This emerging canine disease constitutes an important public health concern among veterinarians and active surveillance is advised to explore its zoonotic potential.
A two step size NLMS adaptive filter algorithm

A new FIR adaptive filter algorithm is proposed. In the proposed algorithm the step size adjustment is controlled by using the square of the output error. A large output error will cause the step size /spl alpha//sub 2/ to provide faster tracking, while a small-output error will result in a step size /spl alpha//sub 1/ yielding a smaller misadjustment. If when the mean square error is larger than some boundary, the, step size is set equal to /spl alpha//sub 2/ and when the mean square error becomes smaller than the boundary the step size is set equal to /spl alpha//sub 1/. There are two ways to select the umbral decision; by a fixed umbral and by a correlation criterion. Computer simulations show that the proposed algorithm achieves a better mean square error than a normalized LMS algorithm. the authors also compared the proposed algorithm with another variable step algorithm, achieving a better convergence time with the same mean square error. <<ETX>>
Parametrically driven variable‐reluctance generator

In the parametrically driven variable‐reluctance generator, the inductance of an iron‐core inductor is varied at an acoustic frequency by an external force. Nonlinear effects thereby absorb mechanical power from the external force and deliver electrical power to a load connected to the inductor, with the electrical phenomena occurring at half the frequency of the mechanical phenomena. Both a theoretical description of this device and measurements in agreement with the theory are presented. Several interesting nonlinear dynamical phenomena can be observed with this simple system; it is also capable of highly efficient power transduction.
Expression of Cytokine Profiles in Human THP-1 Cells during Phase Transition of Talaromyces marneffei

Talaromyces marneffei, a dimorphic fungus, exhibits temperature-dependent growth, existing in a filamentous form at 25 °C and as a yeast at 37 °C. Several studies have highlighted the important roles of macrophages in defense against T. marneffei infection. However, the immune responses to the interaction of macrophages with T. marneffei cells during phase transition require further investigation. This study reports the expression of cytokine profiles in human THP-1 cells during infection by T. marneffei. THP-1 cells were infected with T. marneffei conidia at different multiplicity of infections (MOIs). Surviving conidia transformed into yeasts after phagocytosis by macrophages, and the number of yeasts gradually increased over 36 h. The transcription and secretion levels of pro- and anti-inflammatory cytokines were examined at different times by qRT-PCR and ELISA. Transcription levels of IL-8, IL-12, IL-1β, and TNF-α increased significantly at 12 or 24 h and then slightly decreased at 36 h. In contrast, the transcription levels of IL-6, IL-10, and TGF-β gradually increased at all MOIs. The levels of IL-6 and IL-10 secretion corresponded to their levels of transcription. These results indicated that as the number of intracellular yeasts increased, the infected macrophages first underwent slight M1 polarization before shifting to M2 polarization. This polarization transition was confirmed by the fungicidal ability and the expression of macrophage surface markers. By inducing the M2-type polarization of macrophages, the intracellular T. marneffei cells can successfully evade the immune response. Our study provides a novel insight into the immune characterization during the transition of T. marneffei infection and could further contribute to possible diagnostic and therapeutic interventions for this infection.
Mechanical and electrostatic properties of carbon nanotubes under tensile loading and electric field

Coupled mechanical and electronic behaviours of single walled open carbon nanotubes (CNTs) under applied electric field and tensile loading are investigated by the use of quantum mechanics as well as quantum-molecular dynamics techniques based on the Roothaan–Hall equations and the Newton motion laws. Different failure mechanisms and mechanical properties are found for CNTs subjected to electric fields and that subjected to tensile load. The electric field induced breaking in CNT begins from the outmost carbon atomic layers while the tensile load breaks the nanotube near its middle at 300 K. Electronic polarization and mechanical deformation induced by an electric field can significantly change the electronic properties of a CNT. Under electric field, the CNT can be stretched but the toughness is much lower than that under mechanical loading. Applied tensile loading causes no electronic polarization even in a metallic tube but it indeed changes the energy gap of the tube, thus exhibits influence on field-emission properties of CNTs. When a tube is tensioned in an electric field, the critical tensile strength of the tube may decrease significantly with increasing intensity of electric field. The coupling of mechanical and electrical behaviours is an important characteristic of CNTs.
Fault‐tolerant adaptive control allocation schemes for overactuated systems

This paper presents a fault‐tolerant adaptive control allocation scheme for overactuated systems subject to loss of effectiveness actuator faults. The main idea is to use an ‘ad hoc’ online parameters estimator, coupled with a control allocation algorithm, in order to perform online control reconfiguration whenever necessary. Time‐windowed and recursive versions of the algorithm are proposed for nonlinear discrete‐time systems and their properties analyzed. Two final examples have been considered to show the effectiveness of the proposed scheme. The first considers a simple linear system with redundant actuators and it is mainly used to exemplify the main properties and potentialities of the scheme. In the second, a realistic marine vessel scenario under propeller and thruster faults is treated in full details. Copyright © 2010 John Wiley & Sons, Ltd.
Fi-Vi: Large-Area Indoor Localization Scheme Combining ML/DL-Based Wireless Fingerprinting and Visual Positioning

Due to recent technological developments such as online navigation, augmented reality (AR), virtual reality (VR), and digital twins, and the high demand from users for various location-based services (LBS), research on location estimation techniques is being actively conducted. As a result, there is an increasing demand for effective localization technologies that can be used in places where the use of Global Positioning System (GPS) is limited, especially in indoor spaces with very large areas. In this paper, a new structure for an indoor localization system in which wireless fingerprinting and visual-based positioning are hierarchically combined—the so-called Fi-Vi system—is proposed. This scheme consists of two steps: fingerprint-based localization (FBL) followed by visual-based localization (VBL). In the first positioning step (i.e., the FBL stage), the entire area of a significantly broad range for localization is divided into multiple regions, the size and the number of which depend on the target accuracy of this step. Moreover, a machine-learning (ML) or deep-learning (DL) model trained on a Wi-Fi fingerprint radio map selects suitable candidate regions among these multiple regions. In the second positioning step (i.e., the VBL stage), the final location is precisely estimated through visual-based positioning based on the received information regarding the candidate regions. The FBL stage uses a sparse radio map (SRM) for fingerprinting, which can be constructed with relatively little effort and cost compared to radio maps used in conventional fingerprinting methods. As a result, it can be easily combined with existing visual-based positioning methods with almost negligible implementation complexity. Because of the hierarchical structure and SRM, the proposed scheme shows a significant performance improvement in terms of computational load and time required for indoor localization compared to the use of the existing visual-based indoor positioning method alone. In addition, it provides high accuracy and robustness even in a dynamically changing indoor wireless environment where conventional wireless fingerprinting methods show significant performance degradation. Finally, the performance analysis of the proposed scheme was performed using the UJIIndoorLoc dataset. Experiments and theoretical analysis have shown that when the estimation accuracy of the candidate region for the test dataset was achieved at about 99% through the FBL stage, the average computational amount of the VBL stage for the final position estimation was only about 16% of that in cases where the visual-based positioning method was used alone.
An extension of the equilibrium fluctuation relations

Recently, we have derived a generalization of the known canonical fluctuation relation between the heat capacity and the energy fluctuations $C=\beta^{2} $, which is able to describe the existence of macrostates with negative heat capacities $C $ and $K_{T}=\beta /V$, in order to consider the existence of macrostates with anomalous values in response functions such as the isothermal susceptibility in a paramagnetic system $\chi_{T}=\partial M/\partial H$ or the isothermal compressibility of a fluid system $K_{T}=-V^{-1}(\partial V/\partial p)_{T}$. Finally, we discuss some simple application examples and perform a numerical testing of some consequences of the present generalization by studying the anomalous diamagnetic states of the 2D Ising model through Monte Carlo simulations.
Dietary Intake and Physical Activity of Thai Children and Adolescents with Type 1 Diabetes Mellitus

Appropriate dietary intake and physical activity (PA) are essential for glycemic control and optimal growth in youth with type 1 diabetes (T1D). Thus, this study aimed to compare dietary intake and PA between youth with T1D and healthy controls. One hundred Thai youth with T1D and 100 age-matched healthy participants were recruited. A 3-day food record was completed and converted into nutrient intake data. PA data were collected via interview. Participants with T1D had a significantly higher mean ± SD carbohydrate (50.8 ± 6.8% vs. 46.2 ± 7.5%, p < 0.01), lower fat (32.4 ± 5.9% vs. 35.9 ± 6.4%, p < 0.01), and lower protein (16.8 ± 2.6% vs. 17.9 ± 3.5%, p = 0.01) intake compared to controls. Fifty percent of T1D participants and 41% of control participants consumed saturated fat more than recommendations (p = 0.20). Participants with T1D had a higher median (IQR) calcium intake compared to controls (474 (297–700) vs. 328 (167–447) mg/day, p < 0.01). Both groups consumed less fiber and more sodium compared to recommendations. Both groups had inadequate PA. Participants with T1D had significantly less PA compared to controls (25 (13–48) vs. 34 (14–77) minutes/day, p = 0.04). In addition to the need for counseling that promotes consumption of more dietary fiber and calcium and less saturated fat and sodium, the benefits of performing regular exercise need to be emphasized among youth with T1D.
Using Humor to Sell Product : The Case of Heineken

Today marketing is in the middle of a main paradigm alteration. Instead of fear or other distress, more and more marketers are shifting to humor (Stanley 2015). The influences of humor in advertisement have long been of great apprehension in academicals as well as practical. In Vietnam, humor in advertisement has been engaged by various brands, yet little understanding of its application has been presented. Furthermore, preceding researches had shown that humor also contributes to the advertising effectiveness, get customers attention as well as enhance the attitude of customers toward the ads. Methodically, this research employed quantitative approach, which applied Structural Equation Modeling, utilized by Partial Least Square method (PLS-SEM) analysis for a sample size of 120 respondents. The results have confirmed significant impacts of Humor on advertisement likability and Consumer attitude toward the brand as well as their beliefs toward the brand and Brand Purchase Intention. Significantly, there are considerate recommendations for advertisers in Vietnam.
MOF-Derived MnO/C Nanocomposites for High-Performance Supercapacitors

As ordered porous materials, metal–organic frameworks (MOFs) have attracted tremendous attention in the field of energy conversion and storage due to their high specific surface area, permanent porosity, and tunable pore sizes. Here, MOF-derived MnO/C nanocomposites with regular octahedral shape were synthesized using a Mn-based analogue of the MIL-100 framework (Mn-MIL-100, MIL: Matérial Institut Lavoisier) as the precursor. Using aberration-corrected environmental transmission electron microscopy (ETEM), MnO nanocages with a diameter of approximately 20 nm were recognized in the MnO/C nanocomposites fabricated, dispersed in a microporous carbon matrix homogeneously. The nanocages are composed of MnO nanoparticles with a diameter of approximately 2 nm and with a single crystal structure. The specific surface area of the as-prepared MnO/C octahedra decreases to 256 m2 g−1 from 507 m2 g−1 of the Mn-MIL-100 precursor, whereas the total pore volume increases to 0.245 cm3 g−1, which is approximately 29% higher than that of the precursor (0.190 cm3 g−1). Additionally, when utilized as an electrode for supercapacitors, the MOF-derived MnO/C nanocomposite demonstrates a towering specific capacitance of 421 F g−1 at 0.5 A g−1 and good cycle stability (94%) after 5000 cycles. Our work reveals that the MnO nanoparticles in MOF-derived MnO/C nanocomposites exhibit nanocage structure characteristics, which might be inherited from the Mn-MIL-100 precursor with analogous supertetrahedron units.
Maternal Inherited Thrombophilia in Monochorionic Twin Pregnancy with Twin-Twin Transfusion Syndrome

Background: To study the frequency of inherited thrombophilia in monochorionic twin pregnancies with twin-twin transfusion syndrome (TTTS). Methods: At the Department of Obstetrics of the Polytechnic University of Marche (Ancona, Italy) a population of monochorionic diamniotic pregnant women was selected retrospectively. After termination of the pregnancy, genotyping for Factor I, Factor V Leiden, Factor II and Methylenetetrahydrofolate Reductase (MTHFR), as well as activities of the plasma proteins C and S, was performed. Results: Regarding the 32 patients with TTTS, from a cohort of 104 monochorionic pregnancies recruited, at least one thrombophilic defect was more frequent (OR: 3.24), and the allele polymorphism frequency was higher for Factor I (OR: 4.4) and for Factor V Leiden (OR: 11.66). Conclusions: Maternal inherited thrombophilia, possibly also inherited from monochorial fetuses, may result in impaired development of the placental vascular architecture. This inheritance hypothesis may explain why only a fraction of monochorionic diamniotic twins develop TTTS.