Miracle-dz/UniFAR-FTUs huggingface dataset:
Bioethical education on deliberation: the views of a novel

Ethics is the study of the moral basis of human behavior that aims to determine the best course of action. Bioethics, as a transdisciplinary area, based both on ethics and on life sciences, reflects upon the ethical problems raised by new technologies and scientific research. One of the main tools to tackle bioethical problems is deliberation, a procedure that attempts to analyse problems, weighing up the principles and values involved as well as the context of each case. Due to the complexity of deliberation, educational projects should be promoted, providing the practice necessary for correct deliberation and raising awareness of the current ethical issues. It is our purpose to present a framework for ethical deliberation throughout the use of literature. Literary texts are essential, since they show human beings acting in space and time and they give the readers an opportunity to deliberate on ethical issues. Based on a literary text, we will reflect upon a controversial ethical issue Preimplantion Genetic Diagnosis (PGD).
Strategic Framing Suggested Alternate Head : Framing , Strategic

Framing is a rhetorical tool used by communicators to delimit the scope of a situation or argument. Although media framing has received the extensive attention since late 1970s (→Framing Effects, Framing of News), the framing construct employed to understand communication in a wide range of disciplines—including speech, organizational behavioral, economics, political science, psychology and sociology. Strategic framing involves the purposeful use of this technique by rhetors, social advocates and communications professionals in fields such as public relations and advertisers. The goals of strategic framing are to telegraph meaning and to focus audience attention on particular portions of a message or aspects of a topic in order to gain favorable response. Framing is a critical element in constructing social reality because it helps shape the perceptions and provides context for processing information. Similar to how a surrounding picture frame delimits a landscape painting, strategic communicators use message frames to create salience for certain elements of a topic by including and focusing attention on them while excluding other aspects. Message framing provides contextual cues that bias cognitive processing and decisionmaking. These cues can operate at the conscious or subconscious level during the pre-attention and focal attention phases of processing by message recipients. Framing effects are mediated through the psychological process of priming whereby messages activate particular schemas (networks of associations and knowledge stored in memory). Strategic framing thus prompts people to think in particular, desired ways about a topic and to use only a portion of their extant knowledge stored in memory. In so doing, framing shapes inferences made about the definition, causes, and remedy of situations (Entman, 1993). Framing has been cited as a textual, psychological or socio-political construct in more than a 1,000 citations related to the strategic use of framing. These can be categorized into a typology of seven models of framing:
Re-ranking Google search returned web documents using document classification scores

Web document ranking is a very challenging issue for search engines because about 80% of the search engine users are usuallyinterested in the top three returned search results only. This paper proposes an effective method for re-ranking Google searchreturned web documents/pages based on document classification. This method downgrades some web documents/pages thathave lower classification scores or been classified into categories irrelevant to the query. The experimental results show thatthe re-ranking of Google search returned web documents using document classification scores can significantly improve theranking performance in terms of the integrated evaluation result using three criteria: MAP, nDCG, and P@20. It is evident thatthe proposed re-ranking method can meet the user’s information need better.
Assessment of Prognosis of Cirrhosis

Once patients with cirrhosis experience decompensation, early mortality risk increases sharply. Liver transplantation has transformed the prognosis of decompensated cirrhosis. Child-Pugh score has been the reference for many years for assessing the prognosis of cirrhosis. However, Child-Pugh score has important limitations among which is subjective interpretation of some of its variables, making it difficult to categorize patients according to their own disease severity. The model for end-stage liver disease (MELD) score, which was originally designed for assessing the prognosis of cirrhotic patients undergoing transjugular intrahepatic portosystemic shunt (TIPS), is a continuous score relying on three objective variables. Along with TIPS, MELD score proved to be a robust marker of early mortality across a wide spectrum of causes of cirrhosis, even though 10 to 20% of patients are still misclassified. MELD is especially useful for prioritizing candidates for transplantation according to a "sickest first" policy. However, MELD is not a universal prognostic marker of cirrhosis and several MELD exceptions require more specific approaches.
Antarctic sea ice extent variability and its global connectivity

Abstract This study statistically evaluates the relationship between Antarctic sea ice extent and global climate variability. Temporal cross correlations between detrended Antarctic sea ice edge (SIE) anomaly and various climate indices are calculated. For the sea surface temperature (SST) in the eastern equatorial Pacific and tropical Indian Ocean, as well as the tropical Pacific precipitation, a coherent propagating pattern is clearly evident in all correlations with the spatially averaged (over 12° longitude) detrended SIE anomalies (〈SIE*〉). Correlations with ENSO indices imply that up to 34% of the variance in 〈SIE*〉 is linearly related to ENSO. The 〈SIE*〉 has even higher correlations with the tropical Pacific precipitation and SST in the tropical Indian Ocean. In addition, correlation of 〈SIE*〉 with global surface temperature produces four characteristic correlation patterns: 1) an ENSO-like pattern in the Tropics with strong correlations in the Indian Ocean and North America (r > 0.6); 2) a telecon.
Mendelian randomization as an instrumental variable approach to causal inference

In epidemiological research, the causal effect of a modifiable phenotype or exposure on a disease is often of public health interest. Randomized controlled trials to investigate this effect are not always possible and inferences based on observational data can be confounded. However, if we know of a gene closely linked to the phenotype without direct effect on the disease, it can often be reasonably assumed that the gene is not itself associated with any confounding factors — a phenomenon called Mendelian randomization. These properties define an instrumental variable and allow estimation of the causal effect, despite the confounding, under certain model restrictions. In this paper, we present a formal framework for causal inference based on Mendelian randomization and suggest using directed acyclic graphs to check model assumptions by visual inspection. This framework allows us to address limitations of the Mendelian randomization technique that have often been overlooked in the medical literature.
Distinct Distal Gut Microbiome Diversity and Composition in Healthy Children from Bangladesh and the United States

Background Our current understanding of the composition and stability of the human distal gut microbiota is based largely on studies of infants and adults living in developed countries. In contrast, little is known about the gut microbiota and its variation over time in older children and adolescents, especially in developing countries. Methodology/Principal Findings We compared the diversity, composition, and temporal stability of the fecal microbiota of healthy children, ages 9 to 14 years, living in an urban slum in Bangladesh with that of children of the same age range in an upper-middle class suburban community in the United States. We analyzed >8,000 near full-length 16S rRNA gene sequences and over 845,000 pyrosequencing reads of the 16S rRNA V1–V3 region. The distal gut of Bangladeshi children harbored significantly greater bacterial diversity than that of U.S. children, including novel lineages from several bacterial phyla. Bangladeshi and U.S. children had distinct fecal bacterial community membership and structure; the microbiota of Bangladeshi children was enriched in Prevotella, Butyrivibrio, and Oscillospira and depleted in Bacteroides relative to U.S. children (although similar to Bangladeshi adults). Furthermore, community membership and structure in Bangladeshi children was significantly less stable month-to-month than U.S. children. Conclusions/Significance Together, these results suggest that differing environmental or genetic factors may shape the microbiota of healthy children in the two countries. Further investigation is necessary to understand the mechanisms and factors that underlie these differences, and to incorporate these findings into new strategies for the prevention and treatment of childhood and adolescent diseases.
Characterization of atomic defects on the photoluminescence in two‐dimensional materials using transmission electron microscope

Two‐dimensional material (2D) that possesses atomic thin geometry and remarkable properties is a star material for the fundamental researches and advanced applications. Defects in 2D materials are critical and fundamental to understand the chemical, physical, and optical properties. Photoluminescence arises in 2D materials owing to various physical phenomena including activator/dopant‐induced luminescence and defect‐related emissions, and so forth. With the advanced transmission electron microscopy (TEM) technologies, such as aberration correction and low voltage technologies, the morphology, chemical compositions and electronic structures of defects in 2D material could be directly characterized at the atomic scale. In this review, we introduce the applications of state‐of‐the‐art TEM technologies on the studies of the role of atomic defects in the photoluminescence characteristics in 2D material. The challenges in spatial and time resolution are also discussed. It is proved that TEM is a powerful tool to pinpoint the relationship between the defects and the photoluminescence characteristics.
Long-term antiplatelet therapy following myocardial infarction: implications of PEGASUS-TIMI 54

Dual antiplatelet therapy (DAPT) is standard treatment for patients with acute coronary syndromes (ACS), typically comprising the use of aspirin with either an irreversible thienopyridine P2Y12 inhibitor, clopidogrel or prasugrel, or reversibly binding ticagrelor. Pivotal studies led to guidelines recommending DAPT for up to 12 months post-ACS. Despite this, there remains a significant burden of coronary artery disease (CAD)-related events up to and after this period. Recent meta-analyses, including both patients with ACS and patients with stable CAD treated with DAPT following percutaneous coronary intervention, have suggested that long-term thienopyridine-based DAPT reduces the risks of myocardial infarction (MI) and stent thrombosis but may paradoxically increase all-cause mortality risk. The PEGASUS-TIMI 54 (Prevention of Cardiovascular Events in Patients with Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin - Thrombolysis in Myocardial Infarction 54) study examined the effects of long-term DAPT with aspirin and ticagrelor, compared with aspirin alone, on major adverse cardiovascular events (MACE) and complications, including bleeding in patients with prior history of MI. It showed that, over a 3-year period, ticagrelor reduced the risk of MACE but increased non-fatal bleeding risk. Overall, the PEGASUS-TIMI 54 results demonstrate that patients with a history of ACS deemed to be at high risk of further ischaemic events, particularly those in whom the risks of ischaemic events and cardiovascular death outweigh the risk of life-threatening bleeding, may benefit from prolonged ticagrelor-based DAPT. Guidelines are emerging which reflect this. The relationship between aspirin and ticagrelor, particularly with regard to aspirin dosing, remains to be fully elucidated and attention has recently been turned to the option of ticagrelor monotherapy. Future studies will explore optimal individualised strategies for long-term antiplatelet therapy.
Olfactory relationships of the telencephalon and diencephalon in the rabbit. II. An autoradiographic and horseradish peroxidase study of the efferent connections of the anterior olfactory nucleus

The efferent connections of the anterior olfactory nucleus in the female albino rabbit have been studied using the autoradiographic and horseradish peroxidase methods for tracing axonal pathways. Following a unilateral injection of 3H‐leucine into the olfactory peduncle, radioactively labeled efferent projections from the anterior olfactory nucleus were traced into all layers of the ipsilateral main olfactory bulb beneath the olfactory nerve layer and through the ipsilateral anterior limb of the anterior commissure and plexiform layer of the medial side of the cerebral hemisphere to the deep half of the plexiform (IB) and pyramidal cell (II) layers of the prepyriform cortex, the tenia tecta, and the entire surface of the olfactory tubercle. Labeled projections crossing the midline within the anterior commissure were followed to layers IB and II of the contralateral anterior prepyriform cortex and pars externa, pars lateralis, and pars dorsalis of the anterior olfactory nucleus, and through the periventricular layer of the olfactory peduncle to all layers of the main olfactory bulb beneath the olfactory nerve layer. No well‐defined labeled projection was traced to the contralateral accessory olfactory bulb. Evidence for possible anterior olfactory nucleus and/or prepyriform cortical projections to the ipsilateral paleocortical half of the claustrum, horizontal limb of the nucleus of the diagonal band, the posterior lateral hypothalamus at the level of the mammillary complex, and to the bed nucleus of the stria terminalis is discussed. Intra‐axonal retrograde transport of horseradish peroxidase from axon terminals to parent cell bodies after unilateral injection of the protein into the main olfactory bulb or anterior olfactory nucleus revealed that anterior olfactory nucleus projections to the olfactory bulbs and the contralateral anterior olfactory nucleus arise predominately from the pars externa.
Systemic Exposure to and Disposition of Catechols Derived from Salvia miltiorrhiza Roots (Danshen) after Intravenous Dosing DanHong Injection in Human Subjects, Rats, and Dogs

DanHong injection is a Danshen (Salvia miltiorrhiza roots)-based injectable solution for treatment of coronary artery disease and ischemic stroke. Danshen catechols are believed to be responsible for the injection’s therapeutic effects. This study aimed to characterize systemic exposure to and elimination of Danshen catechols in human subjects, rats, and dogs receiving intravenous DanHong injection. A total of 28 catechols were detected, with content levels of 0.002–7.066 mM in the injection, and the major compounds included tanshinol, protocatechuic aldehyde, salvianolic acid B, rosmarinic acid, salvianolic acids A and D, and lithospermic acid with their daily doses ≥10 μmol/subject. After dosing, tanshinol, salvianolic acid D, and lithospermic acid exhibited considerable exposure in human subjects and rats. However, only tanshinol had considerable exposure in dogs. The considerable exposure to tanshinol was due to its having the highest dose, whereas that to salvianolic acid D and lithospermic acid was due to their relatively long elimination half-lives in the human subjects and rats. Protocatechuic aldehyde and rosmarinic acid circulated in the bloodstream predominantly as metabolites; salvianolic acids A and B exhibited low plasma levels with their human plasma metabolites little or not detected. Tanshinol and salvianolic acid D were eliminated mainly via renal excretion. Elimination of other catechols involved hepatobiliary and/or renal excretion of their metabolites. Methylation was found to be the primary metabolism for most Danshen catechols and showed intercompound and interspecies differences in rate and degree in vitro. The information gained here is relevant to pharmacological and toxicological research on DanHong injection.
Drug-related side effects of long-term intrathecal morphine therapy.

BACKGROUND The introduction of intrathecal opioid administration for intractable chronic non-malignant pain and cancer pain is considered as one of the most important breakthroughs in pain management. Morphine, the only opioid approved by FDA for intrathecal administration, has been increasingly utilized for this purpose. For over 3 decades, there have been numerous reports on the non-nociceptive side effects associated with ever increasing long-term intrathecal morphine usage. OBJECTIVES To review the literature on side effects due to long-term intrathecal morphine therapy with discussions of alternate treatment options. DESIGN English-language publications were identified through MEDLINE search and the bibliographies of identified articles were reviewed. RESULTS Most side effects of intrathecal morphine therapy are dose dependent and mediated by opioid receptors. Common ones include nausea, vomiting, pruritus, urinary retention, constipation, sexual dysfunction, and edema. Less common ones include respiratory depression, and hyperalgesia. Catheter tip inflammatory mass formation is a less common complication that may not be mediated by opioid receptors. CONCLUSION The utilization of intrathecal morphine administration for cancer and intractable non-malignant chronic pain represents an important leap forward in pain management. Yet, a wide variety of non-nociceptive side effects may also occur in susceptible patients. The side effects due to intrathecal morphine administration are mostly mediated by opioid receptors. Treatment usually involves the utilization of opioid receptor antagonist, such as naloxone. Patients considering intrathecal opioid pump therapy should be informed and advised about the possible side effects associated with long-term intrathecal morphine administration prior to placement of a permanent morphine infusion pump.
Greedy bi-criteria approximations for k-medians and k-means

This paper investigates the following natural greedy procedure for clustering in the bi-criterion setting: iteratively grow a set of centers, in each round adding the center from a candidate set that maximally decreases clustering cost. In the case of $k$-medians and $k$-means, the key results are as follows. $\bullet$ When the method considers all data points as candidate centers, then selecting $\mathcal{O}(k\log(1/\varepsilon))$ centers achieves cost at most $2+\varepsilon$ times the optimal cost with $k$ centers. $\bullet$ Alternatively, the same guarantees hold if each round samples $\mathcal{O}(k/\varepsilon^5)$ candidate centers proportionally to their cluster cost (as with $\texttt{kmeans++}$, but holding centers fixed). $\bullet$ In the case of $k$-means, considering an augmented set of $n^{\lceil1/\varepsilon\rceil}$ candidate centers gives $1+\varepsilon$ approximation with $\mathcal{O}(k\log(1/\varepsilon))$ centers, the entire algorithm taking $\mathcal{O}(dk\log(1/\varepsilon)n^{1+\lceil1/\varepsilon\rceil})$ time, where $n$ is the number of data points in $\mathbb{R}^d$. $\bullet$ In the case of Euclidean $k$-medians, generating a candidate set via $n^{\mathcal{O}(1/\varepsilon^2)}$ executions of stochastic gradient descent with adaptively determined constraint sets will once again give approximation $1+\varepsilon$ with $\mathcal{O}(k\log(1/\varepsilon))$ centers in $dk\log(1/\varepsilon)n^{\mathcal{O}(1/\varepsilon^2)}$ time. Ancillary results include: guarantees for cluster costs based on powers of metrics; a brief, favorable empirical evaluation against $\texttt{kmeans++}$; data-dependent bounds allowing $1+\varepsilon$ in the first two bullets above, for example with $k$-medians over finite metric spaces.
The multi-band non-thermal emission from the supernova remnant RX J1713.7−3946

Non-thermal X-rays and very high energy (VHE) y -rays have been detected from the supernova remnant (SNR) RX J1713.7-3946, and the recent observations with the Suzaku satellite clearly reveal a spectral cut-off in the X-ray spectrum, which directly relates to the cut-off of the energy spectrum of the parent electrons. However, whether the origin of the VHE γ-rays from the SNR is hadronic or leptonic is still in debate. We studied the multi-band non-thermal emission from RX J1713.7-3946 based on a semi-analytical approach towards the non-linear shock acceleration process by including the contribution of the accelerated electrons to the non-thermal radiation. The results show that the multi-band observations on RX J1713.7-3946 can be well explained in the model with appropriate parameters, and the TeV γ-rays have hadronic origin, i.e. they are produced via proton-proton interactions as the relativistic protons accelerated by the shock collide with the ambient matter.
Do Your School Policies Provide Equal Access to Computers? Are You Sure?.

Research indicates that inequities exist in computer access and learning Some of the inequities are well known: (1) students in wealthy schools have more access to computers than students in poor schools; the ratio of students to com puters is 54:1 in the wealthiest districts and ""31 in the poorest schools (Mar keting Data Retrieval 198S); (21 disadvantaged students spend most of their computer time on drill-and-practice
A PHA‐L analysis of ascending projections of the dorsal raphe nucleus in the rat

Ascending projections from the dorsal raphe nucleus (DR) were examined in the rat by using the anterograde anatomical tracer, Phaseolus vulgaris leucoagglutinin (PHA‐L). The majority of labeled fibers from the DR ascended through the forebrain within the medial forebrain bundle. DR fibers were found to terminate heavily in several subcortical as well as cortical sites.