Miracle-dz/UniFAR-FTUs huggingface dataset:
Multiple ion channel block by the cation channel inhibitor SKF‐96365 in myocytes from the rabbit atrioventricular node

The atrioventricular node (AVN) of the cardiac conduction system coordinates atrial–ventricular excitation and can act as a subsidiary pacemaker. Recent evidence suggests that an inward background sodium current, IB,Na, carried by nonselective cation channels (NSCCs), contributes to AVN cell pacemaking. The study of the physiological contribution of IB,Na has been hampered, however, by a lack of selective pharmacological antagonists. This study investigated effects of the NSCC inhibitor SKF‐96365 on spontaneous activity, IB,Na, and other ionic currents in AVN cells isolated from the rabbit. Whole‐cell patch‐clamp recordings of action potentials (APs) and ionic currents were made at 35–37°C. A concentration of 10 μmol/L SKF‐96365 slowed spontaneous action potential rate by 13.9 ± 5.3% (n = 8) and slope of the diastolic depolarization from 158.1 ± 30.5 to 86.8 ± 30.5 mV sec−1 (P < 0.01; n = 8). Action potential upstroke velocity and maximum diastolic potential were also reduced. Under IB,Na‐selective conditions, 10 μmol/L SKF‐96365 inhibited IB,Na at −50 mV by 36.1 ± 6.8% (n = 8); however, effects on additional channel currents were also observed. Thus, the peak L‐type calcium current (ICa,L) at +10 mV was inhibited by 38.6 ± 8.1% (n = 8), while the rapid delayed rectifier current, IKr, tails at −40 mV following depolarization to +20 mV were inhibited by 55.6 ± 4.6% (n = 8). The hyperpolarization‐activated current, If, was unaffected by SKF‐96365. Collectively, these results indicate that SKF‐96365 exerts a moderate inhibitory effect on IB,Na and slows AVN cell pacemaking. However, additional effects of the compound on ICa,L and IKr confound the use of SKF‐96365 to dissect out selectively the physiological role of IB,Na in the AVN.
Normalization, Social Bonding, and Emotional Support— A Dog’s Effect within a Prison Workshop for Women

ABSTRACT A fundamental tenet of the Danish Prison System is the principle of normalization, meaning that prisons are organized in such a way that the conditions within the walls more or less resemble the conditions outside them. When prison conditions differ as little as possible from normal daily life on the outside, it underpins rehabilitation efforts. To have contact with animals during incarceration can be seen as a part of normalization and thus contributing to rehabilitation. However, in Danish prisons, animal-based programs are not usually offered, nor are prisoners allowed to keep a pet. In an open prison, a women’s prison workshop was established in 2014. In response to prisoners’ requests for contact with animals, an employee brought her own dog during the hours of the workshop, from Monday to Friday. In Denmark and the other Scandinavian countries, not much attention has been given to the effect of the human–animal bond within prisons. To document how well it might work, qualitative methods for data collection were used, including interviews with incarcerated women (n = 12) and staff (n = 3) and participant observation (67 hours) within the women’s workshop. The dog contributed to normalize the prison setting, and participants revealed that the dog improved social relations between inmates and between staff and inmates. Finally, the dog provided comfort to the incarcerated women when they had to deal with difficult personal feelings. A recommendation for policy makers and prison officials arising from this study is that animals should be a normal part of the prison setting.
Indoor positioning using magnetic compass and accelerometer of smartphones

Traditionally location positioning was confided to outdoor environments, mostly using GPS. GPS signals require direct-line-of-sight for accurate positioning. Due to complexity of electromagnetic wave propagation in indoor environments, the GPS based approaches used for outdoor positioning become less effective for indoor location estimation. A novel approach for Wi-Fi based indoor tracking system is presented in this paper which uses the knowledge of magnetic compass and accelerometer in smartphones to locate users. The proposed system is purely software based with no additional hardware and costs. Experimental measurement results indicate that the proposed technique supports sub-meter positioning accuracy.
Static and dynamic power management in 14nm FDSOI technology

This work presents a 14nm technology designed for high speed and energy efficient applications using FDSOI transistors. -34% speed delay at same static power with -100mV Vdd supply voltage operation vs 28nm FDSOI is demonstrated. The specific FDSOI features for adjusting the threshold voltage and managing power are highlighted in this paper. It is shown that a light channel doping and reverse back bias are effective to reduce the static leakage and, on the other hand, forward back bias (FBB) can provide dynamic power saving at same speed. All this process & design techniques, in addition to the poly bias capability, makes FDSOI a highly flexible technology to maximize the speed/leakage/power compromise for each application product.
Identification and validation of novel small proteins in Pseudomonas putida Novel small proteins inP. putida

Recent quantitative electron paramagnetic resonance spectroscopy (EPR) data on different copper species present in copper exchanged in CHA zeolites are presented and put into context with the literature on other copper zeolites. The information were obtained using ex-situ and in-situ EPR on copper ion exchanged into a CHA zeolite with Si/Al = 14 ± 1 to obtain Cu/Al = 0.46 ± 0.02. The results shed light on the identity of different copper species present after activation in air. Since the EPR signal is quantifiable, the content of the different EPR active species has been elucidated and Cu 2+ in 2Al positions in the 6-membered rings (6mr) of the CHA structure has been characterized. Some copper species are found not to give an EPR signal at ambient or high temperatures. Fortunately treatments with different gasses under in-situ conditions are able to trigger an EPR signal and thus reveal information about the reactivity and the quantity of some of the otherwise EPR silent species. In this way the [Cu-OH] + species in copper substituted low-Al zeolites has been indirectly observed and quantified. EPR active Cu 2+ species have been followed under reduction and oxidation with gas mixtures relevant for the selective catalytic reduction of NO with NH 3 (NH 3 -SCR) revealing that all Cu 2+ in 6mr are easily reduced and oxidized at 200°C. Furthermore a stable [Cu-NO 3 ] + species is identified in Cu-CHA after exposure to NO and O 2 , but is not stable in 2Al 6mr sites of the CHA structure under the applied conditions.
The Effects of Reboxetine and Venlafaxine on ECG Variables in Depressed Patients

Antidepressants exert distinct effects on cardiac autonomic nervous system function depending on their receptor profile; thus, different groups of antidepressants are expected to insuence cardiac parameters in varying degrees. This study compares the effects of venlafaxine, a serotonin and noradrenaline reuptake inhibitor and reboxetine, a selective noradrenaline reuptake inhibitor, on ECG parameters and vital signs. Methods: The cardiac parameters and vital signs of 44 depressed patients were evaluated. The initial dose of venlafaxine XR was 75 mg/day and the dose was increased to 150 mg/day at the end of the 2nd week. Reboxetine was started at 4 mg/day and increased to 8 mg/day at the end of the 2nd week of the study. Electrocardiography (ECG) was performed and the PR, QRS, QT, and QTc intervals were measured both at the beginning and at the end of the trial, as were the vital signs. Results: The heart rate was significantly increased in the reboxetine group (Wilcoxon z=-3.510, p
Diagrams, jars, and matchsticks: A systemicist’s toolkit

Participants in cognitive psychology experiments on reasoning and problem solving are commonly sequestered: Efforts are made to impoverish the physical context in which the problem is presented, decoupling people from the richer and modifiable environment that naturally instantiates it outside the lab. Sense-making activities are constrained, but this conforms to the strong internalist and individualist commitments implicit to these research efforts: Cognition reflects internal computations and the scientists’ toils must focus on the individual and what she is thinking, decoupled from the world. We contrast this position with one that identifies cognition as the product of a cognitive system that is configured and enacted by, minimally, an agent and the world in which she is embedded. We review work on the psychology of hypothesis testing and problem solving and argue that refocusing research efforts on the dynamic agent-environment couplings that generate cognitive products — such as a problem representation, a hypothesis or a problem solution — offers a much richer set of methodological opportunities to unveil how people actually think outside the cognitive psychologist’s laboratory. We conclude by exploring the ontological implications of a systemic perspective on cognition.
Energy harvesting wireless networks with correlated energy sources

This work considers a system with two energy harvesting (EH) nodes transmitting to a common destination over a random access channel. The amount of harvested energy is assumed to be random and independent over time, but correlated among the nodes possibly with respect to their relative position. A threshold-based transmission policy is developed for the maximization of the expected aggregate network throughput. Assuming that there is no a priori channel state or EH information available to the nodes, the aggregate network throughput is obtained. The optimal thresholds are determined for two practically important special cases: i) at any time only one of the sensors harvests energy due to, for example, physical separation of the nodes; ii) the nodes are spatially close, and at any time, either both nodes or none of them harvests energy.
An overview of opportunistic ad hoc communication in urban scenarios

In the era of the Internet of Everything, users with handheld or wearable devices equipped with sensing capability have become producers as well as consumers of information and services. The more powerful these devices get, the more likely it is that they will generate and share content locally, through ad hoc opportunistic connectivity, leading to the presence of distributed information sources and forwarders and the diminishing role of centralized, infrastructure-based servers. Despite this interesting portrait, the mobile and volatile nature of this network presents severe challenges demanding new networking techniques able to cope with the unpredictable and resource-constrained nature of mobile entities comprising it. In this context, we discuss novel data gathering and dissemination strategies in urban scenarios which do not rely on strict infrastructure mediation. While preserving the general aspects of our study and without loss of generality, we focus our attention toward practical applicative case studies which help us capture the characteristics of ad hoc opportunistic communication networks, and devise efficient solutions for use in real applicative contexts.
Astrocytes take the stage in a tale of signaling-metabolism coupling

Astrocytes are crucial cells in the brain that are intimately coupled with neuronal metabolism. A new paper from San Martín et al. provides evidence that physiological levels of the gaseous signal molecule NO can rapidly and reversibly increase astrocyte metabolism of glucose and production of lactate. A proposed neurological coupling—from the potential source of NO, endothelial cells, to the potential beneficiary from the lactate, neurons—prompts new questions regarding the controversial role of lactate in the brain.
How Jury Service Makes Us into Better Citizens

Studies on juries have often relied entirely on self-reported data (surveys) or a handful of in-depth interviews. In either case, the skeptic can doubt the truth claims about the jury based on this evidence. After all, many addicted smokers assert that they can “quit tomorrow. ” Are they any less reliable than others who self-report? To be fair, surveys and interviews have their place as legitimate research tools, but we did not feel they were definitive enough to decide our real money wager. The test we proposed to resolve our wager about the civic impact of jury deliberation avoids common measurement problems by linking official jury records with the actual democratic act of voting as recorded by the county’s registrar of voters. This is not the best way to understand the robust and varied nature of civic engagement, but it can demonstrate whether an effect exists under the most rigorous of testing conditions. Although subject to human error, the public records we gather do not depend on fragile human memory or anyone’s desire to impress an interviewer. Given that the researchers and recording clerks only meet long after the court and voting documents have been produced, bias in the recording of the data is implausible. In addition, this approach can yield as close to a perfect response rate as the archives will allow, with little chance that jurors’ experience at the courtroom could influence the odds of their appearing in our final dataset. Because jury service is mandatory, it also brings into our study many people who embark on their public service journey at the county courthouse only reluctantly. Finally, our approach allows us to collect data spanning a period of years, such that we can measure the impact of jury service on voting in elections held months or even years after the study participants completed their service.
Serum iron concentration and total iron binding capacity in patients of oral squamous cell carcinoma

The serum iron concentration and Total Iron Binding Capacity (TIBC) status of 24 patients of oral squamous cell carcinoma (OSCC) were compared with the findings of 13 healthy subjects. OSCC was found to have association with low serum iron level. More patients were found to be with significantly lower iron content in serum (p&lt0.05). But no association between serum TIBC and increased risk of cancer was found (p&gt0.05). Irrespective of age, sex, smoking and betel nut chewing habit of subjects, low serum iron level significantly increase the risk of oral malignancy.
Enabling the Hardware for Computational Photography: Mark Horowitz Turned Ideas into Working Hardware Systems

Prof. Mark Horowitz's work in solid-state circuits and very-large-scale integration is well known to most in the industry. However, many readers may be unaware of his fundamental contributions to the field of computational photography. He has repeatedly found opportunities to advance the state of the art by turning theoretical ideas into working hardware systems. Along the way, he mentored and guided several students toward successful research careers. In this article, written through a series of conversations with his students, two closely related projects in the computational imaging of light fields are reviewed.
Consuming the Home. Walking the Thin Line between Welfare and catastrophe

The financialisation of the world economy has enabled households to build welfare and accumulate assets with borrowed money. But it has also led to a more unstable economy and recurrent financial crises. Norway is one of the few European countries being only lightly affected by the current one. Instead, the country is marked by more than two decades of economic upturn. However, during times when “everybody” is getting rich, people are also moving into risk positions that may prove difficult to tackle over time. Based on recent survey data, this paper explores how severe potentials for crisis are building up among Norwegian households through extensive ‘equity borrowing’ whereby homeowners spend their housing wealth by rolling back the costs of consumption into an existing mortgage. The practice means that households, encouraged by a favourable system with low interest rates and sales-oriented lenders, speculate with their future incomes against expectations for rising property prices. As a result, both mortgage volumes and home prices have risen to unprecedented levels. Economists generally expect the “market” to “fix” any imbalances through so-called “corrections” where “unnatural” housing prices are brought down to reasonable proportions. This may be unproblematic as long as such corrections are done at a point in time when the system is still “sound”. The paper argues that this is no longer the case for Norway as the level of borrowing is too high.
Iron chelators for the treatment of iron overload disease: Relationship between structure, redox activity, and toxicity

The success of the iron (Fe) chelator desferrioxamine (DFO) in the treatment of β‐thalassemia is limited by its lack of bioavailability. The design and characterization of synthetic alternatives to DFO has attracted much scientific interest and has led to the discovery of orally active chelators that can remove pathological Fe deposits. However, chelators that access intracellular Fe pools can be toxic by either inhibiting Fe‐containing enzymes or promoting Fe‐mediated free radical damage. Interestingly, toxicity does not necessarily correlate with Fe‐binding affinity or with chelation efficacy, suggesting that other factors may promote the cytopathic effects of chelators. In this review, we discuss the interactions of chelators and their Fe complexes with biomolecules that can lead to toxicity and tissue damage. Am. J. Hematol. 73:200–210, 2003. © 2003 Wiley‐Liss, Inc.
Metoclopramide-associated tardive dyskinesia. An analysis of 67 cases.

OBJECTIVE To summarize information regarding the frequency, risk factors, clinical characteristics, treatment, and course of metoclopramide hydrochloride-associated tardive dyskinesia obtained from an analysis of 67 case reports. DATA SOURCES All the case reports of metoclopramide-associated tardive dyskinesia involving human patients in the literature in English obtained by using Index Medicus and Med-Search. The indexing terms used were as follows: metoclopramide, tardive dyskinesia, dyskinesia, parkinsonism, and extrapyramidal side effects. STUDY SELECTION For a patient to be included, the main published research criteria had to be met based on the information provided. These criteria included exposure to metoclopramide for at least 30 days before the onset of dyskinesia. Fifty-two patients met these criteria. DATA EXTRACTION One author independently extracted the data. DATA SYNTHESIS The incidence and prevalence of tardive dyskinesia associated with metoclopramide have not been well studied. The mean (+/- SD) length of treatment with metoclopramide before the onset of symptoms was 20 +/- 15 months. The most common location of the dyskinetic movements was the face (28 [60%] of 47) followed by the tongue (21 [45%] of 47). In 15 (71%) of 21 patients on whom long-term follow-up was provided, the symptoms were still present 6 months or more after discontinuation of metoclopramide. CONCLUSION Persistent tardive dyskinesia is a serious potential side effect associated with metoclopramide treatment.
Perceptual Organisation of Configural and Visual Patterns in Schizophrenia: Effects of Repeated Exposure

Recent evidence suggests that although schizophrenia patients can process aspects of visual form to which the visual system is ''hard-wired'' to respond, they are deficient in consolidating novel, unstructured visual information into memory traces, thus limiting the assessment of meaning and the generation of top-down influences to guide further processing. This hypothesis was tested with 18 chronic schizophrenia patients and 18 controls using a familiarity judgement task. As predicted, schizophrenia patients' ability to recognise a highly structured visual pattern increased as a function of experience. In contrast, recognition performance for an unstructured pattern did not improve even after 120 exposures. These data suggest that schizophrenia is characterised by a reduced ability to initiate experience-based changes in the visual system, wherein a group of noncontiguous elements that recur together and that are behaviourally relevant begins to be processed as a single unit. These data, and significant .
On a matrix model of level structure

We generalize the dimensionally-reduced Yang–Mills matrix model by adding a d = 1 Chern–Simons term and terms for a bosonic vector. The coefficient, κ, of the Chern–Simons term must be an integer, and hence the level structure. We show at the bottom of the Yang–Mills potential, the low-energy limit, only the linear motion is allowed for D0 particles. Namely, all the particles align themselves on a single straight line subject to κ2/r2 repulsive potential from each other. We argue the relevant brane configuration to be D0-branes in a D4 after κ of D8s pass the system.
A probabilistic mixture model for mining and analyzing product search log

The booming of e-commerce in recent years has led to the generation of large amounts of product search log data. Product search log is a unique new data with much valuable information and knowledge about user preferences over product attributes that is often hard to obtain from other sources. While regular search logs (e.g., Web search logs) contain click-throughs for unstructured text documents (e.g., web pages), product search logs contain clickth-roughs for structured entities defined by a set of attributes and their values. For instance, a laptop can be defined by its size, color, cpu, ram, etc. Such structures in product entities offer us opportunities to mine and discover detailed useful knowledge about user preferences at the attribute level, but they also raise significant challenges for mining due to the lack of attribute-level observations. In this paper, we propose a novel probabilistic mixture model for attribute-level analysis of product search logs. The model is based on a generative process where queries are generated by a mixture of unigram language models defined by each attribute-value pair of a clicked entity. The model can be efficiently estimated using the Expectation-Maximization (EM) algorithm. The estimated parameters, including the attribute-value language models and attribute-value preference models, can be directly used to improve product search accuracy, or aggregated to reveal knowledge for understanding user intent and supporting business intelligence. Evaluation of the proposed model on a commercial product search log shows that the model is effective for mining and analyzing product search logs to discover various kinds of useful knowledge.
Analyze Login and Certification Time Based on SOA with EIP Architecture

Applications based on Service-Oriented Architecture (SOA) structure are highly active and accountable to change significance at runtime. This justifies the need for monitoring serene services during lifetime service execution. Especially, in a process industry environment distant type of domains can refer to, for example, process instrumentation and monitoring, execution of process control, data acquisition and computation, etc. However, SOA framework techniques are allowing new ways for users and developers to manage, control and benefit from the services, which are being made applicable. In this paper, we describe a novel framework between the Enterprise Information Portal (EIP) and information systems, which based on SOA. It endorses the Enterprise Service Bus (ESB) is a core scheme of SOA, and unified by EIP authentication and management, in which we investigate the performance of login and certification process between the users, and all kinds of information systems. The experiment shows the login and certificate response time and its significant for different number of users. This frame work is realizable for local and multi-disciplinary private industry systems.