Miracle-dz/UniFAR-FTUs huggingface dataset:
Diverse expression patterns of the EMT suppressor grainyhead‐like 2 (GRHL2) in normal and tumour tissues

The transcription factor grainyhead‐like 2 (GRHL2) plays a crucial role in various developmental processes. Although GRHL2 recently has attracted considerable interest in that it could be identified as a novel suppressor of the epithelial‐to‐mesenchymal transition, evidence is emerging that GRHL2 also exhibits tumour‐promoting activities. Aim of the present study therefore was to help defining the relevance of GRHL2 for human cancers by performing a comprehensive immunohistochemical analysis of GRHL2 expression in normal (n = 608) and (n = 3,143) tumour tissues using tissue microarrays. Consistent with its accepted role in epithelial morphogenesis, GRHL2 expression preferentially but not exclusively was observed in epithelial cells. Regenerative and proliferating epithelial cells with stem cell features showed a strong GRHL2 expression. Highly complex GRHL2 expression patterns indicative of both reduced and elevated GRHL2 expression in tumours, possibly reflecting potential tumour‐suppressing as well as oncogenic functions of GRHL2 in distinct human tumours, were observed. A dysregulation of GRHL2 expression for the first time was found in tumours of non‐epithelial origin (e.g., astrocytomas, melanomas). We also report GRHL2 copy number gains which, however, did not necessarily translate into increased GRHL2 expression levels in cancer cells. Results obtained by meta‐analysis of gene expression microarray data in conjunction with functional assays demonstrating a direct regulation of HER3 expression further point to a potential therapeutic relevance of GRHL2 in ovarian cancer. Hopefully, the results presented in this study may pave the way for a better understanding of the yet largely unknown function of GRHL2 in the initiation, progression and also therapy of cancers.
Non-fragile L2–L∞ control for Markov jump systems with general transition probabilities against multiple disturbances

This paper is concerned with the non-fragile L2–L∞ control problem of Markovian jump nonlinear systems. The considered transition probabilities are more general, which covers known case, uncertain case and unknown case. A disturbance generated by an exogenous system is estimated based on a disturbance observer to construct non-fragile state feedback controller with additive gain variations. Simultaneously, another kind of disturbance in L2[0, ∞) space is also been dealt with. The induced nonlinearity by uncertain transition probabilities has been solved based on a separated technique. Some sufficient conditions to guarantee the closed-loop system stochastically stable are obtained by using Lyapunov method and linear matrix inequalities technique. Finally, a single link robot arm model is used to illustrate the effectiveness of the proposed method.
Assessment of the Tomographic Values in Keratoconic Eyes After Collagen Crosslinking Procedure

Goal: This study aimed to investigate the differences in values of K1 and K2 readings, the central corneal thickness (PAH) before the collagen crosslinking procedure (CXL) and 3, 6, 12 months later. Methods: 64 eyes were evaluated in retrospective cross sectional study. The corneal biomechanical parameters were taken with WaveLight Allegro Oculyzer produced by Alcon before the CXL, 3,6, 12 months after the procedure. The curvature of K1 reading and K2 reading were taken and the central corneal thickness were considered due to the time after CXL. Results: The value of K1 reading before the treatment was 48.8 diopters (D) (46.65-50.50) and was statistically significant lower comparing to the value of K1 3 months after the collagen CXL procedure 46.30 D (43.57-49.45) (p=0.0006), K1 reading one year post collagen CXL procedure was 47.20 D (44.35-50.07) (p=0.002). The value of K2 reading before the collagen CXL procedure was 52.65 D (47.55-54.72), 3 months after the procedure was 51.4 (45.05-54.0), 6 months later 48.55 D (47.20-50.62), 12 months later 51.30 D (47.22-54.77). There is statistically significant lower value of K2 reading 6 months after the treatment comparing to the values 3 months postoperatively (p=0.014). However there is significantly lower values of K2 reading 12 months postoperatively comparing to preoperative period (p=0.006). The value of central corneal thickness preoperative was 431.0 microns (398.0-446.25), 3 months after collagen CXL procedure was 373.50 microns (363.25-430.75), 6 months later 435.0 microns (360.0-464.75), 12 months after the CXL procedure was 429.50 microns (357.75-496.25). There is statistically significant lower values of central corneal thickness 3 months after collagen CXL treatment comparing to the central corneal thickness preoperative (p<0.005). There is statistically significant lower values of pachymetry 12 months after the CXL procedure comparing to the values 6 months later (p=0.036) and those preoperativelly (p=0.032). There is no statistically significant difference in the values of central corneal thickness in the period from 3 and 6 months postoperatively. Conclusion: After riboflavin-UVA CXL in eyes with keratokonus there was significant decrease in central corneal thickness 3 and 6 months after the procedure and the thickness is almost the same 12 months. However, K2 (Kmax) reading is significantly changed 3 and 6 months later and is followed by changing of K1 reading.
The Antioxidative Effect of Chamomile, Anthocyanoside and their Combination on Bleomycin-induced Pulmonary Fibrosis in Rat

Introduction: Bleomycin is a small peptide with 1500Daltun of molecular weight which has two junction areas in two molecule’s opposite sides, one of them to relate to the DNA and the other to relate to the iron. Iron is a crucially important factor in free radical production and cytotoxic activity of bleomycin. Material and methods: The study attempts to study, and compare, the effect of using Chamomile, Anthocyanoside and their combination, as anti-inflammatory agent to ameliorates, to prevent or control the development of fibrosis due to Bleomycin (BLM). to prepare pulmonary fibrosis model, male Wistar rats weighting 180-220g were assigned to specific groups Rats of each group received intratracheally 1U/100 g of BLM. 20 rats were divided to five comparable groups, as(1) BLM group, (2) saline group, (3) Chamomile group, (4) Anthocyanoside group, (5) combination of Anthocyanoside and Chamomile group. Antioxidative combinations were given as pretreatment and treatment after the rats received Bleomycine. Results: After 3 week, Malondialdehyde (MDA)was measured for each rat’s lung. After three weeks, MDA was reduced, compared to BLM group, to 44.27%, 37.80% and 46.07% in Anthocyanoside, Chamomiland combination group, respectively. It was concluded from the present study that administration of combination of Chamomile and Anthocyanoside lead to a significant reduction in Bleomycin-induced MDA. Conclusion: The mechanism of the effect of these combinations is possibly the result of phenolic combinations as antioxidant and oxy free radical scavenger and inhibitor of lipid peroxidation.
Shape recognition by bag of contour fragments with a learned pooling function

Bag of Contour Fragments (BoCF), derived from the well-known Bag-of-Features (BoF), is an effective framework for shape representation. The feature pooling in this framework is a critical step, while either max pooling or average pooling is not a learnable process. In this paper, we aim at learning a pooling function which is adaptive to the input contour fragment features instead. Towards this end, we formulate our pooling function as a weighted sum of max pooling and average pooling, where the weight is expressed by an activation function of the input contour fragment features. To automatically learn this weight, the output of the pooling function is fed into a SVM classifier and they are trained jointly to minimize a shape classification loss. Experimental results on several standard shape datasets demonstrate the effectiveness of the proposed learned pooling function, which can achieve considerable improvements compared with BoCF.
Inhibition of miR-155 attenuates abdominal aortic aneurysm in mice by regulating macrophage-mediated inflammation

The aim of the present study was to identify abdominal aortic aneurysms (AAA)-associated miR-155 contributing to AAA pathology by regulating macrophage-mediated inflammation. Angiotensin II (AngII)–infused apolipoprotein E-deficient (ApoE-/-) mice and THP-1 cells model of miR-155 overexpression and deficiency were used in the experiments. The expression of miR-155 was detected by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Cytokines were evaluated using enzyme-linked immunoabsorbent assay (ELISA). Western blotting was used to measure the levels of MMP-2, MMP-9, iNOS, and monocyte chemoattractant protein (MCP)-1 proteins. Immunostaining and transwell were used to determine CD68, elastic collagen, proliferation, and migration of vascular smooth muscle cells (VSMCs). The results showed that miR-155 and cytokines were up-regulated in AAA patients or ApoE-/- mice. Overexpression of miR-155 enhanced MMP-2, MMP-9, iNOS, and MCP-1 levels, and stimulated the proliferation and migration of VSMCs. Meanwhile, inhibition of miR-155 had the opposite effect. In addition, histology demonstrated accumulation of CD68 and elastic collagen-positive areas significantly decreased in miR-155 antagomir injection group. In conclusion, the results of the present study suggest that inhibiting miR-155 is crucial to prevent the development of AAA by regulating macrophage inflammation.
Prevalence of Occult Bacteremia in Infants With Very High Fever Without a Source

We carried out a prospective registry-based cohort study at the emergency department of 363 previously healthy well-appearing infants 3–24 months of age with fever without a source ≥40.5°C based on local protocol. Four were diagnosed with occult bacteremia (1.1%; 95% confidence interval: 0–2.2). Recommendations for nontesting for occult bacteremia screening in these children may have to be reconsidered when fever ≥40.5°C. Larger studies are needed to confirm these results.
EHBDroid: Beyond GUI testing for Android applications

With the prevalence of Android-based mobile devices, automated testing for Android apps has received increasing attention. However, owing to the large variety of events that Android supports, test input generation is a challenging task. In this paper, we present a novel approach and an open source tool called EHBDroid for testing Android apps. In contrast to conventional GUI testing approaches, a key novelty of EHBDroid is that it does not generate events from the GUI, but directly invokes callbacks of event handlers. By doing so, EHBDroid can efficiently simulate a large number of events that are difficult to generate by traditional UI-based approaches. We have evaluated EHBDroid on a collection of 35 real-world large-scale Android apps and compared its performance with two state-of-the-art UI-based approaches, Monkey and Dynodroid. Our experimental results show that EHBDroid is significantly more effective and efficient than Monkey and Dynodroid: in a much shorter time, EHBDroid achieves as much as 22.3% higher statement coverage (11.1% on average) than the other two approaches, and found 12 bugs in these benchmarks, including 5 new bugs that the other two failed to find.
MU-MIMO-OFDM with spreading codes for user separation

This paper presents a multiuser (MU)-multiple-input multiple-output (MIMO)-orthogonal frequency division multiplexing (OFDM) scheme that realizes signal separation among mobile terminals by spreading codes. In conventional multi-user MIMO systems, the most significant problem is co-channel interference among mobile terminals. The calculation of weight coefficients requires the channel state information (CSI) of all the terminals. Owing to a Doppler shift, the accurate CSI is difficult to obtain for mobile terminals. Signals to the other stationary terminals cause severe interference and beam nulling can not be realized appropriately. Thus, this paper proposes an MU-MIMO-OFDM scheme with orthogonal spreading codes that separates signals for mobile terminals. Numerical results obtained through computer simulation show that the proposed scheme improves bit error rate (BER) performance by 2.5dB at a BER of 10−3 in comparison with the conventional MU-MIMO on a Rayleigh fading channel.
Urban-rural disparity of overweight/obesity distribution and its potential trend with breast cancer among Chinese women

Objective To evaluate the urban-rural disparity of overweight/obesity and explore its potential trend with breast cancer among Chinese women. Results The prevalence of overweight/obesity for Chinese rural women (35.2%, 29.2% for overweight and 6.0% for obesity) was significantly higher than that for Chinese urban women (33.4%, 27.7% for overweight and 5.7% for obesity) (P < 0.001). For either rural or urban women, the prevalence of overweight/obesity was highest in north region, followed by east region for rural women and north-east region for urban women. For rural women, higher prevalence of overweight/obesity was significantly positively associated with elder age, Han nationality, low level of education, no occupation, high family income, less number of family residents, insurance, and elder age at marriage. Similar positive associations were also found for urban women, except negative associations for high family income, less number of family residents, and elder age at marriage. A non-significant positive trend between overweight/obesity and breast cancer was found for rural women [odds ratio (OR): 1.06; 95% confidence interval (CI): 0.87–1.29], but a significant positive trend for urban women (OR: 1.55; 95% CI: 1.19–2.02). Materials and Methods A total of 1 210 762 participants were recruited from the Chinese National Breast Cancer Screening Program. Overweight and obesity were defined as body mass index (BMI) ranged 24.0–27.9 kg/m2 and BMI ≥ 28.0kg/m2, respectively. Conclusions There was an obvious urban-rural disparity of overweight/obesity distribution among Chinese women, which could also lead to an obvious disparity of breast cancer distribution.
Active Control of Magnetic Field Using eDMP Model for Biomedical Applications

This paper presents a novel method to actively control magnetic field in a region-of-interest using multiple electromagnets (EMs), referred to here as extended distributed multipole (eDMP). Numerous sensor and actuator applications require controlling magnetic fields such as medical device and automation. However, it is difficult to achieve owing to the nonlinearity of the field and its interaction with various materials. In this paper, the eDMP model is used to compute the magnetic field of the EMs. The method achieves fast and accurate field analysis and it can be utilized to control the desired magnetic field using a set of EMs. The magnetic field generated from various designs of EMs and control of the field is numerically simulated and compared with experiments. Finally, two practical applications are presented to show the effectiveness and accuracy of the method. The first is a transcranial magnetic stimulation (TMS) paradigm used by a medical instrument for diagnosis and treatment of brain disease using magnetic pulses. The effect of the TMS coils on performance is investigated with the eDMP method. The second refers to the locomotion control of a capsule endoscope. Magnetic locomotion can be controlled to attain a desired position and orientation. Simulations and experimental results justify the usefulness of the method that is expected to be extensively applicable.
Semi-Preparative Separation of 10 Caffeoylquinic Acid Derivatives Using High Speed Counter-Current Chromatogaphy Combined with Semi-Preparative HPLC from the Roots of Burdock (Arctium lappa L.)

Burdock roots are healthy dietary supplements and a kind of famous traditional Chinese medicine, which contains large amounts of caffeoylquinic acid derivatives. However, little research has been reported on the preparative separation of these compounds from burdock roots. In the present study, a combinative method of HSCCC and semi-preparative HPLC was developed for the semi-preparative separation of caffeoylquinic acid derivatives from the burdock roots. The ethyl acetate extract of burdock roots was first fractionated by MCI macroporous resin chromatography and give three fractions (Fr. 1–3) from the elution of 40% methanol. Then, these three fractions (120 mg) were separately subjected to HSCCC for purification with the solvent system composed of petroleum ether-ethyl acetate-methanol-water at different volume ratios, and the mixtures were further purified by semi-preparative HPLC. As a result, a total of eight known caffeoylquinic acid derivatives including 3-O-caffeoylquinic acid (32.7 mg, 95.7%), 1,5-O- dicaffeoylquinic acid (4.3 mg, 97.2%), 3-O-caffeoylquinic acid methyl ester (12.1 mg, 93.2%), 1,3-O-dicaffeoylquinic acid (42.9 mg, 91.1%), 1,5-O-dicaffeoyl-3-O-(4-maloyl)-quinic acid (4.3 mg, 84.5%), 4,5-O-dicaffeoylquinic acid (5.3 mg, 95.5%), 1,5-O-dicaffeoyl-3-O-succinylquinic acid (8.7 mg, 93.4%), and 1,5-O-dicaffeoyl-4-O-succinylquinic acid (1.7 mg, 91.8%), and two new compounds were obtained. The new compounds were 1,4-O-dicaffeoyl-3-succinyl methyl ester quinic acid (14.6 mg, 96.1%) and 1,5-O-dicaffeoyl-3-O-succinyl methyl ester quinic acid (3.1 mg, 92.6%), respectively. The research indicated that the combination of HSCCC and semi-preparative HPLC is a highly efficient approach for preparative separation of the instability and bioactive caffeoylquinic acid derivatives from natural products.
Unemployment in the AI age

"Work saves us from three great evils: boredom, vice, and need" Voltaire said (Johnson & Indvik, 2004). Work is essential to the meaning of human life. To many people today, work means having a job. However, artificial intelligence (AI) will soon be able to take over many human jobs. A significant amount of social unrest will be caused by unemployment before the ethical issues of AI can be addressed. Thus, unemployment will be the most pressing social issue with respect to AI technologies.
A Novel NAC-Type Transcription Factor, NAC87, from Oilseed Rape Modulates Reactive Oxygen Species Accumulation and Cell Death

Reactive oxygen species (ROS) are thought to play a dual role in plants by functioning as signaling molecules and toxic by-products of aerobic metabolism. The hypersensitive response (HR) is a typical feature of immune responses in plants and also a type of programmed cell death (PCD). How these two processes are regulated in oilseed rape (Brassica napus L.) at the transcriptional level remains largely unknown. In this study, we report that an oilseed rape (Brassica napus L.) NAM-ATAF-CUC (NAC)-type transcription factor NAC87 modulates ROS and cell death accompanied by typical changes at the morphological and cellular levels. The BnaNAC87 gene was induced by multiple stress and hormone treatments and was highly expressed in senescent leaves by quantitative reverse transcription-PCR (qRT-PCR). BnaNAC87 is located in nuclei and has transcriptional activation activity. Expression of BnaNAC87 promoted significant ROS production, cell death as well as death of protoplasts, as indicated by histological staining. In addition, putative downstream target genes of NAC87 were identified through both qRT-PCR and dual luciferase reporter assays. We found that genes implicated in ROS generation (RbohB), cell death (VPE1a, ZEN1), leaf senescence (WRKY6, ZAT12) and defense (PR2, PR5 and HIN1) were significantly induced. Through an electrophoretic mobility shift assay (EMSA), we confirmed that BnaNAC87 directly binds to the NACRS-containing promoter fragments of ZEN1, ZAT12, HIN1 and PR5 genes. From these results, we conclude that oilseed rape NAC87 is a novel NAC transcription factor that acts as a positive regulator of ROS metabolism and cell death.
Phenomenological Modelling of the Hysteresis Loop in Thermoelastic Martensitic Transformations

We present in this work a simple phenomenological model of the hysteresis loop in thermoelastic martensitic transformations. The model is based on the equilibrium condition arising from the minimization of the Gibbs free energy at every transformation step. For simplicity, the simplest form of the different terms of the balance equation has been taken.
Effects of Ginkgo biloba leaves (Ginkgo biloba) and Ginkgo biloba extract on nutrient and energy utilization of broilers

ABSTRACT An experiment using 112 21‐day‐old male Arbor Acres broilers that were randomly allocated to 7 treatments with 8 replicates in a completely randomized design was conducted to assess the effects of Ginkgo biloba leaves (Ginkgo biloba, GL) and Ginkgo biloba extract (EGB) on utilization of nutrients of broiler chickens. The dietary treatments were corn‐soybean meal based diets: 1) T1, control diet; 2) T2, T1 + 20 g/kg GL; 3) T3, T1 + 40 g/kg GL; 4) T4, T1 + 60 g/kg GL; 5) T5, T1 + 0.4 g/kg EGB; 6) T6, T1 + 0.8 g/kg EGB; and 7) T7, T1 + 1.2 g/kg EGB. Endogenous losses were obtained from another 16 broilers. Excreta samples were collected to analyze the dry matter (DM), organic matter (OM), ether extract (EE), crude protein (CP), gross energy (GE), and amino acids (AA), and GE was analyzed for computation of AME and TME. As compared with those of the control treatment, the apparent digestibility (AD) and true digestibility (TD) of EE, CP, Thr, Val, Ile, Leu, Phe, Lys, His, and Arg were quadratically (P < 0.05) increased; moreover, the AD and TD of Met was linearly (P < 0.05) increased as the concentration of the EGB in the diet increased. Increasing GL from 0 to 60 g/kg of diet linearly (P < 0.05) increased the AD and TD of EE, Thr, Val, Leu, His, and Met and tended (0.05 < P < 0.1) to increase the TME, TMEn, and Arg. Supplementation of EGB increased (P < 0.05) AD and TD of EE, Thr, Val, Ile, Leu, Phe, His, and Arg and tended (0.05 < P < 0.1) to increase Lys as compared with those in the GL‐supplemented groups. Dietary supplementation of GL and EGB improved the utilization of nutrients of broiler chickens in a dose‐dependent manner, and the optimum supplementation levels of GL or EGB in the diet of broilers was 60 or 0.8 g/kg of diet, respectively.
The impact of robotic surgery on quality of life, urinary and sexual function following total mesorectal excision for rectal cancer: a propensity score‐matched analysis with laparoscopic surgery

Quality of life (QoL) and functional outcomes are at risk of being impaired after rectal surgery, but there has been no large prospective study to thoroughly assess QoL according to surgical approach. We have investigated the impact of laparoscopic and robotic total mesorectal excision (TME) on QoL and functional outcomes.
A fuzzy logic control approach for smoothing of wind and photovoltaic generation output fluctuations

Increasing levels of the wind and photovoltaic systems require innovative ways to manage the fluctuations caused due to the intermittent generation profile. This paper proposes a fuzzy logic based control approach to smooth the power output of the collocated wind and photovoltaic generation system. A first order filter is modified with a fuzzy logic controller which regulates the battery power, the state of charge and pitch angle for smoothing of the output power. The controller adjusts the time constant of the filter based on the state of charge of battery and pitch angle of wind generation system by considering the battery power. The effectiveness of the proposed approach is analyzed by considering the different values of the state of charge.