Miracle-dz/UniFAR-FTUs huggingface dataset:
Small‐scale convection in the D″ layer

[1] Small-scale convection has been suggested as a possible explanation for seismic heterogeneities in the D″ layer of the Earth's mantle. Recently developed scaling laws for convection with realistic viscosities allow quantitative assessment of this hypothesis. Large temperature and viscosity contrasts across the thermal boundary layer at the core-mantle boundary suggest that small-scale convection starts at the bottom of the thermal boundary layer and propagates upward before the thermal boundary layer as a whole becomes unstable. The convection boundary is likely to become a chemical boundary as a result of mixing within the convective layer. This implies that the D″ discontinuity can represent both convective and chemical boundary and that the presence or absence of small-scale convection can be responsible for the observed intermittent nature of the D″ discontinuity. Most lateral heterogeneities in the D″ layer are concentrated near the convection boundary, consistent with seismic data. The length scale of lateral temperature variations, the topography of the core-mantle boundary, and the viscosity of the D″ layer are in agreement with observational constraints. The thickness of the secondary thermal boundary layer formed at the bottom of the convective layer is similar to the thickness of the ultralow-velocity zone. The magnitude of lateral variations in temperature can only marginally be responsible for lateral variations in seismic velocities. Variations in the topography of the convection boundary and chemical heterogeneities are likely to be more important factors. A large seismic velocity drop in the ultralow-velocity zone cannot be explained by thermal effects alone and must be caused by other factors such as partial melting.
Nuclear and mitochondrial DNAs microsatellite instability and mitochondrial DNA copy number in adenocarcinoma and squamous cell carcinoma of lung: a pilot study

Mitochondrial genetic changes are considered as a key molecular step of mutations in various cancers. To clarify the role of genetic instability in lung cancer, we analyzed clinicopathological characteristics and frequencies of nuclear and mitochondrial microsatellite instability (nMSI and mtMSI), and alteration of mitochondrial DNA copy number (mtCN) in adenocarcinoma (ADC) and squamous cell carcinoma (SCC) of lung. DNA was isolated from 48 patients with ADC and 42 with SCC. Markers for nMSI, BAT 25 and 26, and markers for mtMSI, (C)n and (CA)n in mitochondrial D‐loop region, were utilized. The mtCN were measured by real‐time polymerase chain reaction. The nMSI was found in two patients (4.2%) of ADC and 6 (14.3%) of SCC. The mtMSI was detected in 10 patients (20.8%) of ADC and 8 (19.0%) of SCC. Mean mtCN was 5.05 ± 8.17 and 3.34 ± 5.14 in ADC and SCC respectively. The mtCN was increased in 35 patients (72.9%) of ADC and 30 (71.4%) of SCC. The mtMSI more frequently appeared in more advanced pathologic T stage in ADC (p = 0.003). Alterations of mtCN and a high frequency of mtMSI in our patient samples indicate that mitochondrial DNA is a potential molecular marker in lung cancers (ADC and SCC) correlating with their histological classification.
Reproductive constraints, direct fitness and indirect fitness benefits explain helping behaviour in the primitively eusocial wasp, Polistes canadensis

A key step in the evolution of sociality is the abandonment of independent breeding in favour of helping. In cooperatively breeding vertebrates and primitively eusocial insects, helpers are capable of leaving the group and reproducing independently, and yet many do not. A fundamental question therefore is why do helpers help? Helping behaviour may be explained by constraints on independent reproduction and/or benefits to individuals from helping. Here, we examine simultaneously the reproductive constraints and fitness benefits underlying helping behaviour in a primitively eusocial paper wasp. We gave 31 helpers the opportunity to become egg-layers on their natal nests by removing nestmates. This allowed us to determine whether helpers are reproductively constrained in any way. We found that age strongly influenced whether an ex-helper could become an egg-layer, such that young ex-helpers could become egg-layers while old ex-helpers were less able. These differential reproductive constraints enabled us to make predictions about the behaviours of ex-helpers, depending on the relative importance of direct and indirect fitness benefits. We found little evidence that indirect fitness benefits explain helping behaviour, as 71 per cent of ex-helpers left their nests before the end of the experiment. In the absence of reproductive constraints, however, young helpers value direct fitness opportunities over indirect fitness. We conclude that a combination of reproductive constraints and potential for future direct reproduction explain helping behaviour in this species. Testing several competing explanations for helping behaviour simultaneously promises to advance our understanding of social behaviour in animal groups.
An assessment of vancomycin pharmacokinetic variability in pediatric cardiology patients.

OBJECTIVES To establish the steady-state pharmacokinetic profile of vancomycin in pediatric cardiology patients; determine an empiric vancomycin dose; and evaluate the correlation between fluid balance and volume of distribution (Vd), serum creatinine and clearance (CL), and daily dose of furosemide and Vd. METHODS Retrospective pharmacokinetic evaluation in 36 pediatric cardiology, cardiac surgery, or cardiac transplant patients treated with vancomycin. The pharmacokinetic profile for vancomycin including elimination half-life (t1/2), elimination rate constant (ke), volume of distribution (Vd), and clearance (CL) was calculated for each patient. The relationship between fluid balance and Vd, serum creatinine and CL, and the total daily dose of furosemide and Vd was evaluated. RESULTS The patient population had an average half-life of 5.9±1.2 hr and a Vd of 0.4±0.12 L/kg. A statistically significant correlation was noted between serum creatinine and CL (r(2)=0.19, P<0.01). Additionally, a statistically significant correlation exists between the total daily furosemide dose and the Vd (r(2)=0.31, P<0.01). A dose of 10 mg/kg/dose every 12 hrs was predicted to result in the greatest number of serum vancomycin concentrations within the reference range. CONCLUSIONS Routine monitoring of serum vancomycin concentrations is prudent for this population, and special consideration should be given to those with elevated serum creatinine and to those receiving large doses of furosemide.
Epidemiological and Clinical Studies in Patients with Mumps in Pleven District, Bulgaria, 2000-2008

Introduction: The implemented during recent 2–3 decades specific immunoprophylactics against mumps led to serious changes on the intensity and dynamics of the disease all over the world. Objectives: To perform epidemiological analysis of the trend of the disease outbreak for the period 2000 till 2008; to investigate the clinical cases with hospitalized subjects for the same period in Pleven district, Bulgaria. Materials and Methods: There have been used data from the National Centere of Infectious and Parasite Diseases, data reports and analysis of Regional Authority for Protection and Control of Public Health-Pleven. One hundred sixty one patients, suffering mumps, hospitalized in Clinic of Infectious Diseases, were included in the survey. Results: For the period 2000–2008 in Pleven district 974 persons fell ill with mumps. The most inflicted were children and young adults: 10–14 and 15–19 years old — 517 (53.08%) in the first group; 282 (28.95%) in the second age group. There were defined the following clinical forms of mumps infection between the hospitalized persons. Conclusion: The conducted clinical-epidemiological survey of mumps shows that in the conditions of popular specific immunoprophylactics the next epidemiological characteristics undergo changes.
Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes: systematic review, meta-analysis, and estimation of population attributable fraction

Objectives To examine the prospective associations between consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice with type 2 diabetes before and after adjustment for adiposity, and to estimate the population attributable fraction for type 2 diabetes from consumption of sugar sweetened beverages in the United States and United Kingdom. Design Systematic review and meta-analysis. Data sources and eligibility PubMed, Embase, Ovid, and Web of Knowledge for prospective studies of adults without diabetes, published until February 2014. The population attributable fraction was estimated in national surveys in the USA, 2009-10 (n=4729 representing 189.1 million adults without diabetes) and the UK, 2008-12 (n=1932 representing 44.7 million). Synthesis methods Random effects meta-analysis and survey analysis for population attributable fraction associated with consumption of sugar sweetened beverages. Results Prespecified information was extracted from 17 cohorts (38 253 cases/10 126 754 person years). Higher consumption of sugar sweetened beverages was associated with a greater incidence of type 2 diabetes, by 18% per one serving/day (95% confidence interval 9% to 28%, I2 for heterogeneity=89%) and 13% (6% to 21%, I2=79%) before and after adjustment for adiposity; for artificially sweetened beverages, 25% (18% to 33%, I2=70%) and 8% (2% to 15%, I2=64%); and for fruit juice, 5% (−1% to 11%, I2=58%) and 7% (1% to 14%, I2=51%). Potential sources of heterogeneity or bias were not evident for sugar sweetened beverages. For artificially sweetened beverages, publication bias and residual confounding were indicated. For fruit juice the finding was non-significant in studies ascertaining type 2 diabetes objectively (P for heterogeneity=0.008). Under specified assumptions for population attributable fraction, of 20.9 million events of type 2 diabetes predicted to occur over 10 years in the USA (absolute event rate 11.0%), 1.8 million would be attributable to consumption of sugar sweetened beverages (population attributable fraction 8.7%, 95% confidence interval 3.9% to 12.9%); and of 2.6 million events in the UK (absolute event rate 5.8%), 79 000 would be attributable to consumption of sugar sweetened beverages (population attributable fraction 3.6%, 1.7% to 5.6%). Conclusions Habitual consumption of sugar sweetened beverages was associated with a greater incidence of type 2 diabetes, independently of adiposity. Although artificially sweetened beverages and fruit juice also showd positive associations with incidence of type 2 diabetes, the findings were likely to involve bias. None the less, both artificially sweetened beverages and fruit juice were unlikely to be healthy alternatives to sugar sweetened beverages for the prevention of type 2 diabetes. Under assumption of causality, consumption of sugar sweetened beverages over years may be related to a substantial number of cases of new onset diabetes.
Impact of Parameter Estimation on the Performance of the FSU Global Spectral Model Using Its Full-Physics Adjoint

Abstract The full-physics adjoint of the Florida State University Global Spectral Model at resolution T42L12 is applied to carry out parameter estimation using an initialized analysis dataset. The three parameters, that is, the biharmonic horizontal diffusion coefficient, the ratio of the transfer coefficient of moisture to the transfer coefficient of sensible heat, and the Asselin filter coefficient, as well as the initial condition, are optimally recovered from the dataset using adjoint parameter estimation. The fields at the end of the assimilation window starting from the retrieved optimal initial conditions and the optimally identified parameter values successfully capture the main features of the analysis fields. A number of experiments are conducted to assess the effect of carrying out 4D Var assimilation on both the initial conditions and parameters, versus the effect of optimally estimating only the parameters. A positive impact on the ensuing forecasts due to each optimally identified parameter .
Application of Immunohistochemistry in Stereology for Quantitative Assessment of Neural Cell Populations Illustrated in the Göttingen Minipig

Background Stereology is the study of estimating geometric quantities. When successfully applied, the combination of immunohistochemistry (IHC) and stereology eliminates intra- and interobserver variability for cell type identification. Methodology/Principal Findings We propose a method to validate existing antibody based cell type markers for stereological application. Comparison was made on the 100-days-old Göttingen minipig (G-mini) neocortex between estimates of total neuron number derived from Giemsa staining using morphological criteria and immunohistochemistry-based cell counting with NeuN. The mean total neuron numbers estimated by the two staining methods were not significantly different. Estimated quantities, including glial cell number, neocortical volume, cell densities and glial-to-neuron ratio were also presented. Additionally, we assessed other commonly used glial markers and discussed how to evaluate the advantages and disadvantages of these markers for stereological estimation of cell number. Conclusion/Significance The concordance in quantitative estimates of total neuron number derived from NeuN- and Giemsa-stained sections provides evidence for the sensitivity and specificity of NeuN as a neuronal marker in the G-mini. Although time-consuming, quantitative validation of IHC should always be considered in stereological studies if there is doubt of the sensitivity, specificity, or reproducibility of cell type markers. Inaccurate staining may cause both over- and underestimation of the total cell number and inflict considerable limitation when analyzing the results.
Segmentation of recordings based on partial transcriptions

In this paper, we present the approach we used to produce a training database from a set of recorded newscasts for which we had inaccurate transcriptions. These transcribed segments correspond to a set of prepared anchor texts and journalist stories, not necessarily in chronological order of their actual presentation. No segmental time boundary information is provided. Our main concern is thus to establish time marks that delimit the audio segments of the corresponding texts. To resolve this problem, we have developped a time marking procedure using our speech recognition engine. We obtain a segmentation accuracy of 80%.
A video stream processor for real-time detection and correction of specular reflections in endoscopic images

This paper presents the architecture and FPGA implementation of a video processor for detection and correction of specular reflections in endoscopic images by using an inpainting algorithm. Stream processing and parallelism are used to exceed real-time performance on NTSC format video without the need for an external memory. The system was implemented in a XC2VP30 FPGA and uses 91% of available slices. Image quality is significantly enhanced.
Driving in Parkinson's disease

Altered motor or mental skills in Parkinson's disease (PD) could adversely affect driving ability. We interviewed 150 patients regarding their driving habits and compared them with 100 controls. Thirty patients had stopped driving because of PD. PD patients had no more lifetime accidents than controls. With increased disability, however, there was a smaller percentage of patients still driving with fewer miles traveled and with proportionately more accidents occurring. Though disability scores did not correlate well with driving ability, there were significantly more accidents in subjects with more severe PD. The presence of cognitive impairment was associated with an increased accident rate. We conclude that driving in PD may be a public health problem and that some PD patients should not drive.
Prevailing papillomavirus types in non‐melanoma carcinomas of the skin in renal allograft recipients

The role of human papillomavirus (HPV) in the aetiology of in situ and invasive carcinoma of the genital tract is well established. In the rare disorder epidermodysplasia verruciformis (EV), in which patients develop extensive warts of unusual types and multiple cutaneous squamous cancers on light‐exposed skin, current evidence suggests a probable role for a specific group of EV HPVs in the carcinogenic process. Determination of the possible role of HPV in the aetiology of non‐melanoma skin cancers (NMSCs), which occur frequently in immunosuppressed organ allograft recipients, has been limited, until recently, by the lack of availability of a sensitive detection system for a wide range of cutaneous HPV types. We have used a combination of 2 sets of PCR primers to examine 68 benign and malignant tumours collected over a 12‐year period from 25 renal allograft recipients. Cloning and sequencing of the PCR products were carried out to distinguish HPV DNA from cellular sequences. A combination of these techniques revealed HPV DNA in all viral warts, 65% of keratoses, 91% of intra‐epidermal cancers and 91% of invasive squamous cancers. Both cutaneous and EV HPV types were detected, including 18 novel types. In 4 patients with multiple cancers, the most prevalent types were in the EV group: HPV 20, 23, 38 and 2 novel types, DL40 and DL267 (related to HPV 10 and 38, respectively). These 5 HPV types were present in a total of 73% of all malignant lesions tested. The technique described represents a reliable method of HPV DNA detection in NMSC. The EV group of HPVs predominate in the cancers, but the multiplicity of HPV types detected with double infection in some lesions suggests virus/virus in addition to virus/host interaction in the carcinogenic process. Int. J. Cancer 73:356–361, 1997. © 1997 Wiley‐Liss, Inc.
Transcription of vocal melodies using voice characteristics and algorithm fusion

This paper deals with the transcription of vocal melodies in music recordings. The proposed system relies on two distinct pitch estimators which exploit characteristics of the human singing voice. A Hidden Markov Model (HMM) is used to fuse the pitch estimates and make voicing decisions. The resulting performance is evaluated on the MIREX 2006 Audio Melody Extraction data.
Adiponectin and Metabolic Syndrome

Abstract—In this review article, the crucial roles of adipocytes in the development of so-called metabolic syndrome and vascular disease are reviewed, focusing on adipocyte-derived bioactive substances, adipocytokines. Recent progress in adipocyte biology shows that adipocytes are not merely energy-storing cells but that they secrete a variety of hormones cytokines, growth factors, and other bioactive substances. To search for novel adipocytokines by the large-scale random sequence analysis of expressed genes in adipocytes, we identified an adipose-specific collagen-like molecule, adiponectin. This novel adipocytokine has plural biofunctions, such as antidiabetic, antiatherosclerotic, and antiinflammatory functions. Adiponectin plasma levels decrease with the accumulation of visceral adipose tissue. In this review, we discuss the link of adiponectin to visceral adiposity, insulin resistance, and vascular diseases.
Molecular Epidemiologic Analysis of Methicillin-Resistant Staphylococcus aureus Isolates from Bacteremia and Nasal Colonization at 10 Intensive Care Units: Multicenter Prospective Study in Korea

We investigated molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) isolated at 10 intensive care units (ICUs) in Korea. MRSA isolates from bacteremia and nasal colonization were collected prospectively from October 2008 through May 2009 at 10 University-affiliated hospital ICUs. A total of 83 and 175 MRSA strains were isolated from bacteremia and nasal colonization, respectively. Acquired group accounted for 69.9% (n = 58) of bacteremia and 73.1% (n = 128) of nasal colonization. Pulsed-field gel electrophoresis (PFGE) type B (SCCmec type II/ST5) was dominant in the acquired group followed by PFGE type D (SCCmec type IVA/ST72; a community genotype). Seven of 58 (12.1%) acquired bacteremia and 15 of 128 (11.8%) acquired nasal colonizations had SCCmec type IVA/ST72 genotype, which indicated that the community genotype had already emerged as a cause of ICU acquired MRSA infection or colonization. Antibiotic resistance rates to ciprofloxacin, tetracycline, clindamycin and trimethoprim/ sulfamethoxazole were 84.4%, 67.1%, 78.1%, and 12.0%, respectively. Susceptibility to ciprofloxacin best predicted a community genotype (sensitivity 96.5%; specificity 96.9%; odds ratio 861; 95% confidence interval 169-4,390, P < 0.001) and the positive predictive value was 90.2%. Among 23 nasal re-colonized strains, 7 MRSA strains (30.4%) were different from the originally colonized strains on the basis of PFGE types.
Optimized low-power elementary function approximation for Chebyshev series approximations

This paper presents a method for computing elementary function using optimized number of most significant bits of coefficients along with truncated multipliers for designing interpolators. The proposed method optimizes the initial coefficient values, which leads to minimize the maximum absolute error of the interpolator output by using a Chebyshev series approximation. The resulting designs can be utilized for any approximation for functions up with smaller requirements for table lookup sizes. Designs for several interpolators that implement reciprocals are presented and analyzed. This paper demonstrates that optimal coefficient values with high precision and smaller lookup table sizes can be optimally compared to standard coefficients for interpolators. The paper presents also VLSI implementation results, targeting a 65nm CMOS technology from IBM.
The distribution of placental oxidoreductase isoforms provides different milieus of steroids influencing pregnancy in the maternal and fetal compartment

Abstract Using information based on the steroid metabolome in maternal and fetal body fluids, we attempted to ascertain whether there is a common mechanism, which is based on the placental distribution of various isoforms of 17β-hydroxysteroid dehydrogenases and aldo-keto reductases. This system simultaneously provides a higher proportion of active progestogens in fetal circulation and a higher proportion of active estrogens and GABAergic steroids in the maternal compartment. The data obtained using gas chromatography-mass spectrometry completely support the aforementioned hypothesis. We confirmed a common trend to higher ratios of steroids with hydroxy-groups in the 3α-, 17β-, and 20α-positions to the corresponding 3-oxo-, 17-oxo-, and 20-oxo-metabolites, respectively, in the maternal blood when compared with the fetal circulation, and the same tendency was obvious in the 3α-hydroxy/3β-hydroxy steroid ratios. A decreasing trend was observed in the ratios of active estrogens and neuro-inhibitory steroids to their inactive counterparts in fetal and maternal body fluids. This was probably associated with a limited capacity of placental oxidoreductases in the converting of estrone to estradiol during the transplacental passage. Although we observed a decreasing trend in pregnancy-sustaining steroids with increasing gestational age, we recorded rising levels of estradiol and particularly of estriol, regardless of the limited capacity of placental oxidoreductases. Besides the estradiol, which is generally known as an active estrogen, estriol may be of importance for the termination of pregnancy with respect to its excessive concentrations near term which allows its binding to estrogen receptors.