Miracle-dz/UniFAR-FTUs huggingface dataset:
Girls' Participation in Basic Education in Southern Malawi

Apres avoir presente une vue d'ensemble sur l'education au Malawi, les AA. examinent les problemes que pose l'education de base des femmes, en deux etudes de cas; puis ils etudient les facteurs socio-culturels et economiques qui entravent la participation des femmes a l'education, et les attitudes des parents, des etudiants et des enseignants vis-a-vis de cette participation
Anti-single-stranded DNA antibody and muscle involvement in localized scleroderma.

To the Editor. — Localized scleroderma differs from systemic sclerosis because of the difference in the distribution of skin sclerosis and the lack of Raynaud's phenomenon, acrosclerosis, and internal involvement. In localized scleroderma, the lesions are usually limited to the skin and to the subcutaneous tissue beneath the cutaneous lesions. However, it has been suggested that the disease has an immunologic basis because the serum samples of patients frequently contain antinuclear antibody (ANA). Recent reports on ANAs by indirect immunofluorescence methods using monolayer cultured cells showed greater frequencies than those by previous standard tests using frozen tissue sections. We first reported that 72% of the patients with localized scleroderma have positive ANAs when HeLa cells served as the test substrate. 1 Recently, Falanga et al 2-4 have reported elevated levels of anti-single-stranded DNA (anti-ss-DNA) antibody in localized scleroderma. They have also shown a positive correlation between anti-ss-DNA antibody and joint contracture
DOES LEARNING ACCELERATE EVOLUTION

This paper reviews the recent progress in the investigation into how learning can effect evolutionary dynamics after a century of sharply con¤icting views. The results are signi£cant both for theoretical biologists of various stripes and for computer scientists working on computational intelligence and other subdisciplines which often rely on the transfer of biological principles to digital systems. This review will focus on interactions which accelerate (Baldwin Effect) or decelerate (Hiding Effect) evolutionary (ge netic) change. Figure 1:A schematic representation of all Baldwin Effects. 1 The Rise and Fall and Rise of the
Beyond the commodity metaphor: Examining emotional and symbolic attachment to place

Abstract In contrast to the dominant multiattribute commodity view of outdoor recreation settings, wilderness users are described as having emotional and symbolic ties to the setting that are manifested as attachment to the site and the wilderness concept. Data from four wilderness areas show stronger place and wilderness attachment to be associated with previous visits, rural residence, a setting (as opposed to activity or group) focus, visiting alone and on weekdays, hunting in the area, and sensitivity to site impacts and horse encounters. Place attachment is also associated with a lack of nonwilderness substitutes and lower income and education. Wilderness attachment is associated with membership in wilderness and conservation organizations, visits to more wilderness areas, a preference for longer visits, participation in nature study, and sensitivity to sight and sound intrusions and hiker encounters. The importance of understanding emotional and symbolic values of natural resources is discussed in r.
Can long-term treatment with antidepressant drugs worsen the course of depression?

BACKGROUND The possibility that antidepressant drugs, while effectively treating depression, may worsen its course has received inadequate attention. METHOD A review of the literature suggesting potential depressogenic effects of long-term treatment with antidepressant drugs was performed. A MEDLINE search was conducted using the keywords tolerance, sensitization, antidepressive agents, and switching. This was supplemented by a manual search of Index Medicus under the heading "antidepressant agents" and a manual search of the literature for articles pointing to paradoxical effects of antidepressants. RESULTS A number of reported clinical findings point to the following possibilities: very unfavorable long-term outcome of major depression treated by pharmacologic means, paradoxical (depression-inducing) effects of antidepressant drugs in some patients with mood and anxiety disturbances, antidepressant-induced switching and cycle acceleration in bipolar disorder, occurrence of tolerance to the effects of antidepressants during long-term treatment, onset of resistance upon rechallenge with the same antidepressant drug in a few patients, and withdrawal syndromes following discontinuation of mood-elevating drugs. These phenomena in susceptible individuals may be explained on the basis of the oppositional model of tolerance. Continued drug treatment may recruit processes that oppose the initial acute effects of a drug and may result in loss of clinical effect. When drug treatment ends, these processes may operate unopposed, at least for some time, and increase vulnerability to relapse. CONCLUSION The possibility that antidepressant drugs may worsen the course of depression needs to be tested, even though its scientific exploration is likely to encounter considerable methodological and ideological difficulties. The clinical implications of this hypothesis in depression are considerable. Antidepressant drugs are crucial in the treatment of major depressive episodes. However, appraisal of paradoxical effects that may occur in susceptible patients during long-term treatment may lead to more effective use of the drugs.
Cardiac autonomic function reveals adaptation to military training

Abstract The last 4 weeks of basic military training are very stressful. We tested the hypothesis that changes in cardiac autonomic function during this period are associated with changes in maximal oxygen uptake and/or serum hormonal concentrations in male conscripts (n=22). Cardiac vagal autonomic function was assessed by measuring the high-frequency (0.15–0.4 Hz) spectral power of R–R intervals. Maximal oxygen uptake ([Vdot]O2max) and basal serum testosterone concentration were measured at the beginning and end of the period. Individual changes in vagally mediated high-frequency power (range −15% to +25%) correlated (r=0.73, P=0.001) with changes in [Vdot]O2max (range −9% to +6%) and changes in testosterone concentration (range −52% to +43%; r=0.43, P=0.047). The mean values of [Vdot]O2max and testosterone concentration did not change during the study period. Measurements of autonomic function could be a useful tool for indicating adaptation to the highly stressful conditions associated with basic military training.
Oxidative and Anti-Oxidative Stress Markers in Chronic Glaucoma: A Systematic Review and Meta-Analysis

Chronic glaucoma is a multifactorial disease among which oxidative stress may play a major pathophysiological role. We conducted a systematic review and meta-analysis to evaluate the levels of oxidative and antioxidative stress markers in chronic glaucoma compared with a control group. The PubMed, Cochrane Library, Embase and Science Direct databases were searched for studies reporting oxidative and antioxidative stress markers in chronic glaucoma and in healthy controls using the following keywords: “oxidative stress” or “oxidant stress” or “nitrative stress” or “oxidative damage” or “nitrative damage” or “antioxidative stress” or “antioxidant stress” or “antinitrative stress” and “glaucoma”. We stratified our meta-analysis on the type of biomarkers, the type of glaucoma, and the origin of the sample (serum or aqueous humor). We included 22 case-control studies with a total of 2913 patients: 1614 with glaucoma and 1319 healthy controls. We included 12 studies in the meta-analysis on oxidative stress markers and 19 on antioxidative stress markers. We demonstrated an overall increase in oxidative stress markers in glaucoma (effect size = 1.64; 95%CI 1.20–2.09), ranging from an effect size of 1.29 in serum (95%CI 0.84–1.74) to 2.62 in aqueous humor (95%CI 1.60–3.65). Despite a decrease in antioxidative stress marker in serum (effect size = –0.41; 95%CI –0.72 to –0.11), some increased in aqueous humor (superoxide dismutase, effect size = 3.53; 95%CI 1.20–5.85 and glutathione peroxidase, effect size = 6.60; 95%CI 3.88–9.31). The differences in the serum levels of oxidative stress markers between glaucoma patients and controls were significantly higher in primary open angle glaucoma vs primary angle closed glaucoma (effect size = 12.7; 95%CI 8.78–16.6, P < 0.001), and higher in pseudo-exfoliative glaucoma vs primary angle closed glaucoma (effect size = 12.2; 95%CI 8.96–15.5, P < 0.001). In conclusion, oxidative stress increased in glaucoma, both in serum and aqueous humor. Malonyldialdehyde seemed the best biomarkers of oxidative stress in serum. The increase of some antioxidant markers could be a protective response of the eye against oxidative stress.
Sequence Similarity Network Reveals Common Ancestry of Multidomain Proteins

We address the problem of homology identification in complex multidomain families with varied domain architectures. The challenge is to distinguish sequence pairs that share common ancestry from pairs that share an inserted domain but are otherwise unrelated. This distinction is essential for accuracy in gene annotation, function prediction, and comparative genomics. There are two major obstacles to multidomain homology identification: lack of a formal definition and lack of curated benchmarks for evaluating the performance of new methods. We offer preliminary solutions to both problems: 1) an extension of the traditional model of homology to include domain insertions; and 2) a manually curated benchmark of well-studied families in mouse and human. We further present Neighborhood Correlation, a novel method that exploits the local structure of the sequence similarity network to identify homologs with great accuracy based on the observation that gene duplication and domain shuffling leave distinct patterns in the sequence similarity network. In a rigorous, empirical comparison using our curated data, Neighborhood Correlation outperforms sequence similarity, alignment length, and domain architecture comparison. Neighborhood Correlation is well suited for automated, genome-scale analyses. It is easy to compute, does not require explicit knowledge of domain architecture, and classifies both single and multidomain homologs with high accuracy. Homolog predictions obtained with our method, as well as our manually curated benchmark and a web-based visualization tool for exploratory analysis of the network neighborhood structure, are available at http://www.neighborhoodcorrelation. org. Our work represents a departure from the prevailing view that the concept of homology cannot be applied to genes that have undergone domain shuffling. In contrast to current approaches that either focus on the homology of individual domains or consider only families with identical domain architectures, we show that homology can be rationally defined for multidomain families with diverse architectures by considering the genomic context of the genes that encode them. Our study demonstrates the utility of mining network structure for evolutionary information, suggesting this is a fertile approach for investigating evolutionary processes in the post-genomic era.
The estrogenic component of tibolone reduces adiposity in female aromatase knockout mice

Objective: To explore the effects of tibolone on adiposity in the absence of aromatase and determine which of the hormonal properties of tibolone are exerting these effects. Methods: In this study, vehicle; tibolone; estrogenic (ethinyl estradiol [EE]), progestogenic (ORG2058), or androgenic (dihydrotestosterone) compounds; or a combination of ORG2058 + EE was administered to 6-month-old ovariectomized aromatase knockout (ArKO) mice for a period of 6 weeks. Results: In response to tibolone or EE-alone treatments, omental adipose tissue and infrarenal adipose tissue weights were significantly reduced (P = 0.004 and P = 0.01; P = 0.009 and P = 0.014, respectively) compared with those in ovariectomized and vehicle-treated ArKO mice. In contrast, adipose tissue weight tended to increase after ORG2058-alone treatment. Furthermore, EE in the presence of ORG2058 (ORG2058 + EE group) results in little effect on adiposity when compared with that in ovariectomized and vehicle-treated ArKO mice, showing that ORG2058 can negate the effect of EE. Dihydrotestosterone treatment did not have an impact on adipose tissue mass. Adipocyte volume and numbers followed the same treatment trends. Conclusions: In summary, our study in the ArKO mouse has confirmed the efficacy of tibolone as a hormone therapy to reduce adipose tissue accumulation after menopause and also shows that aromatization of tibolone is not required to elicit these estrogenic effects.
Adamantane resistance among influenza A viruses isolated early during the 2005-2006 influenza season in the United States.

CONTEXT The adamantanes, amantadine and rimantadine, have been used as first-choice antiviral drugs against community outbreaks of influenza A viruses for many years. Rates of viruses resistant to these drugs have been increasing globally. Rapid surveillance for the emergence and spread of resistant viruses has become critical for appropriate treatment of patients. OBJECTIVE To investigate the frequency of adamantane-resistant influenza A viruses circulating in the United States during the initial months of the 2005-2006 influenza season. DESIGN AND SETTING Influenza isolates collected from 26 states from October 1 through December 31, 2005, and submitted to the US Centers for Disease Control and Prevention were tested for drug resistance as part of ongoing surveillance. Isolates were submitted from World Health Organization collaborating laboratories and National Respiratory and Enteric Virus Surveillance System laboratories. MAIN OUTCOME MEASURES Using pyrosequencing and confirmatory assays, we identified viruses containing mutations within the M2 gene that are known to confer resistance to both amantadine and rimantadine. RESULTS A total of 209 influenza A(H3N2) viruses isolated from patients in 26 states were screened, of which 193 (92.3%) contained a change at amino acid 31 (serine to asparagine [S31N]) in the M2 gene known to be correlated with adamantane resistance. Two of 8 influenza A(H1N1) viruses contained the same mutation. Drug-resistant viruses were distributed across the United States. CONCLUSIONS The high proportion of influenza A viruses currently circulating in the United States demonstrating adamantane resistance highlights the clinical importance of rapid surveillance for antiviral resistance. Our results indicate that these drugs should not be used for the treatment or prophylaxis of influenza in the United States until susceptibility to adamantanes has been reestablished among circulating influenza A isolates.
Expectations and effects of a single yoga session on pain perception

Background: Several studies show yoga may benefit chronic pain management. We investigated the effect of a single yoga session on the perception of pain, measured by a standardized pain provocation test in healthy yoga participants while also comparing pain perception to participants’ own expectations. Materials and Methods: Ninety yoga participants were recruited at hatha yoga schools in Switzerland. Pain perception was measured with a standardized algometric pain provocation test; i.e., a calibrated peg was applied for 10 seconds after which the participant rated pain intensity on a 0–10 numerical rating scale. The test was applied to the middle finger, ear lobe, and second toe before and after a 60-minute yoga session. Results: Sixty out of 90 (66.7%) yoga participants expected a reduced pain perception after the yoga session. However, 36 (40%) participants actually experienced less pain after compared to before the yoga session. But overall, pain perception statistically did not significantly change from before to after the yoga session at any of the three body locations assessed. The expectations and also the previous yoga experience did not significantly influence the participants’ pain perception. Conclusions: Regardless of the high positive expectations on the influence of yoga on pain, a single yoga session does not significantly influence pain perception induced by a pain provocation test. Hypoalgesic effects of yoga should be explained otherwise.
Skirting Amdahl ’ s Law : Using SPSD Execution with Optical Interconnects

Copyright 1996 IEEE. A version of this paper was published in the Proceedings of the 3rd International Conference on Massively Parallel Processing Using Optical Interconencts, October, 1996, Lahaina, Hawaii, USA. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works, must be obtained from the IEEE. Contact: Manager, Copyrights and Permissions, IEEE Service Center, 445 Hoes Lane, P.O. Box 1331, Piscataway, NJ 08855-1331, USA. Telephone: + Intl. 908-562-3966.
Evidence-based practice in occupational therapy services for children with autism spectrum disorders in Victoria, Australia.

BACKGROUND The current practice of occupational therapy services provided for children with autism spectrum disorders in Victoria, Australia was investigated - specifically, practice in terms of the theories, assessments and intervention strategies utilised. Identification of professional development needs was also explored. The purpose was to identify how occupational therapy practice may have changed over the last decade and to explore what additional developments are required in the field. METHOD A self-administered survey was mailed to 322 registered members of Occupational Therapy Australia Limited, Victoria Branch. RESULTS A valid response rate of 20.5% was obtained. The majority of the participants worked in private practice, and had between one and five years of work experience. Theories, assessments and interventions that are associated with or based on, sensory integration and/or processing approaches are highly utilised by the participants in their service delivery with children with autism spectrum disorders. Participants indicated that they felt they needed training and courses around sensory integration. CONCLUSIONS We concluded that there were few changes in occupational therapy practice related to the selection of theoretical models, assessments and interventions by the participants in this study over the last decade. It is essential for occupational therapists not to neglect the goals of providing occupation-based interventions to children with autism spectrum disorders by focusing only on sensory-based approaches. An urgent need for occupation-based approaches to working with children with autism spectrum disorders and their families is required.
U-KNOW - An Example of a Mobile Portal for Knowledge Management

This paper discusses the use of mobile applications in Knowledge Management (mobile KM). Today more and more people leave (or have to leave) their fixed working environment in order to conduct their work at changing locations or while they are on the move. At the same time mobile work is getting more and more knowledge-intensive. However the issue of mobile work and knowledge management is an aspect which has largely been overlooked so far. Based on requirements for mobile applications in KM an example for the implementation of a mobile KM portal at a German university is described. The presented solution offers various services for university staff (information access, colleague finder, campus navigator, collaboration support). The paper is concluded by outlining an important future issue in mobile KM: The consideration of location-based information in mobile KM portals.
Accounting Research from the Globalization Perspective

This paper explores the idea of globalisation and considers accounting's role in that process in order to develop new spaces for accounting research. That's why in this paper we are looking for questions not necessary for answers. Adopting an 'alternative' view of accounting it's related to the fact that we sees accounting as social and evolutionist process, that pays heed to those voices arguing for greater social and environmental justice, and that draws attention to the role of accounting researchers in the process of globalisation. The paper defines globalisation and expands the globalisation and accounting research agenda introducing in this context the harmonization process in accounting. There are the two main systems which are disputing the first stage of being the benchmark: GAAP and IFRS. Each of them has his pluses and minuses on being the selected one. Due to this fact a convergence of the two, joining the advantages and disadvantages of the two should be the solution for an unique international accounting solution. Is this idea realizable, what steps has been made until now, what should be done in the future. The paper is emphasising the role of the cultural differences in the process of imposing of an unique international accounting system by the global organizations.
Designing tangible video games: lessons learned from the sifteo cubes

In this paper, we present a collaborative game designed for Sifteo Cubes, a new tangible interface for multiplayer games. We discuss how this game exploits the platform's interface to transfer some of the game mechanics into the non-digital world, and how this approach affects both the player's experience and the design process. We present the technical limitations encountered during game development and analyze video recordings of play sessions with regard to the play strategies developed by the players. Then, we identify two properties that this game shares with many other games on tangible platforms and discuss how these properties influence both the game design process and the player experience. We advocate that these properties provide players with more freedom and relatedness, while helping to create an easy-to-learn and customizable gameplay, despite their own design limitations.
Characterization of a multi-user indoor positioning system based on low cost depth vision (Kinect) for monitoring human activity in a smart home

An increasing number of systems use indoor positioning for many scenarios such as asset tracking, health care, games, manufacturing, logistics, shopping, and security. Many technologies are available and the use of depth cameras is becoming more and more attractive as this kind of device becomes affordable and easy to handle. This paper contributes to the effort of creating an indoor positioning system based on low cost depth cameras (Kinect). A method is proposed to optimize the calibration of the depth cameras, to describe the multi-camera data fusion and to specify a global positioning projection to maintain the compatibility with outdoor positioning systems. The monitoring of the people trajectories at home is intended for the early detection of a shift in daily activities which highlights disabilities and loss of autonomy. This system is meant to improve homecare health management at home for a better end of life at a sustainable cost for the community.