Miracle-dz/UniFAR-FTUs huggingface dataset:
Linear and Non-Linear Optical Imaging of Cancer Cells with Silicon Nanoparticles

New approaches for visualisation of silicon nanoparticles (SiNPs) in cancer cells are realised by means of the linear and nonlinear optics in vitro. Aqueous colloidal solutions of SiNPs with sizes of about 10–40 nm obtained by ultrasound grinding of silicon nanowires were introduced into breast cancer cells (MCF-7 cell line). Further, the time-varying nanoparticles enclosed in cell structures were visualised by high-resolution structured illumination microscopy (HR-SIM) and micro-Raman spectroscopy. Additionally, the nonlinear optical methods of two-photon excited fluorescence (TPEF) and coherent anti-Stokes Raman scattering (CARS) with infrared laser excitation were applied to study the localisation of SiNPs in cells. Advantages of the nonlinear methods, such as rapid imaging, which prevents cells from overheating and larger penetration depth compared to the single-photon excited HR-SIM, are discussed. The obtained results reveal new perspectives of the multimodal visualisation and precise detection of the uptake of biodegradable non-toxic SiNPs by cancer cells and they are discussed in view of future applications for the optical diagnostics of cancer tumours.
Cognitive Training in Children and Adolescents with Attention Deficit/Hyperactivity Disorder (ADHD)

Background: To examine the feasibility and efficacy of computerized cognitive exercises from Scientific Brain Training (SBT), compared to the computer game Tetris as an active placebo, in a pilot study of adolescents with Attentiondeficit/hyperactivity disorder (ADHD). Method: Eighteen adolescents with ADHD were randomized to treatment or control intervention for seven weeks. Outcome measures were cognitive test, symptom and motivation questionnaires. Results: SBT and Tetris were feasible as home-based interventions and participants’ compliance was high, but participants perceived both interventions as not very interesting or helpful. There were no significant group differences on cognitive and ADHD-symptom measures after intervention. Pre-post intra-group measurement showed that the SBT had a significant beneficial effect on sustained attention, while the active placebo had significant beneficial effects on working memory, both with
PRECISION SOUTHERN HEMISPHERE PULSAR VLBI ASTROMETRY: TECHNIQUES AND RESULTS FOR PSR J1559–4438

We describe a data reduction pipeline for very long baseline interferometry astrometric observations of pulsars, implemented using the ParselTongue AIPS interface. The pipeline performs calibration (including ionosphere modeling), phase referencing with proper accounting for the reference source structure, amplitude corrections for pulsar scintillation, and position fitting to yield the position, proper motion, and parallax. The optimal data weighting scheme to minimize the total error budget of a parallax fit, and how this scheme varies with pulsar parameters such as flux density, is also investigated. The robustness of the techniques employed is demonstrated with the presentation of the first results from a two-year astrometry program using the Australian Long Baseline Array. The parallax of PSR J1559–4438 is determined to be 1π = 0.384 ± 0.081 mas (1σ), resulting in a distance estimate of 2600 pc that is consistent with earlier dispersion measure and HI absorption stimates.
A CPW-Fed Triangular Monopole Antenna with Staircase Ground for UWB Applications

In this paper, a monopole antenna with triangular shaped patch based on coplanar waveguide (CPW)-feed is presented. The proposed antenna comprises a planar triangular patch element with a staircase ground which offers ultra wide bandwidth. The impedance bandwidth can be tuned by changing staircase shaped ground parameters (number of steps, step length, and/or its width). The overall size of the antenna is 28mm×26mm×1.6mm including finite ground CPW feeding mechanism. The antenna operates in the frequency range from 3.2-12GHz covering FCC defined UWB band with more than 100% impedance bandwidth. Stable omni-directional radiation patterns in the desired frequency band have been obtained. Measured data fairly agree with the simulated results.
Simulation of 30kV high-frequency high-voltage power supply with phase shifted control

As the development of control theory in power electronics, kinds of control methods are used in high-voltage power supply's design. Simulation is one of the keys to verify the control method accuracy when designing a supply system. In this paper, a phase shifted control method is utilized in parallel resonant circuit, and the condition of the power electronic switch devices during the process of phase shifting and phase angle changing is analyzed. A system of 30kV high-frequency high-voltage AC power supply with phase shifted control is designed and simulated on the PSIM software. The simulation results prove the effectiveness of the control method, and the reliable design parameters of this system are presented.
Trabajo Social y VIH-SIDA: análisis de prácticas de intervención

El presente articulo da cuenta de la participacion del Trabajo Social con personas que viven con VIH-SIDA (PVVIH-SIDA). En el se muestran la aparicion y el desarrollo del Trabajo Social dentro del campo de la salud y al mismo tiempo la intervencion psicosocial frente a las personas viviendo con VIHSIDA. Los trabajadores sociales han desempenado un papel importante en materia de intervencion en VIH y su intervencion los ha enfrentado a sus propios prejuicios y valores. Hoy, la pandemia confronta al Trabajo Social a un cambio demografico importante: una poblacion que aumenta su esperanza de vida resultado de las terapias «antirretrovirales» (TARV), y a un crecimiento potencial de la proporcion de esta poblacion en condiciones de pobreza, lo que significara una pesada carga de trabajo para los trabajadores sociales. Las practicas de intervencion de los trabajadores sociales con enfasis en la interdisciplinariedad los distinguen como una profesion de apertura y adecuacion a los nuevos problemas sociales
Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses

Biological agents have dramatically improved treatment options for patients with severe psoriasis. Etanercept (tumor necrosis factor [TNF] receptor–immunoglobulin fusion protein) is an effective treatment for many psoriasis patients, and blockade of TNF is considered to be its primary action. However, in this clinical trial, we show that etanercept has early inhibitory effects on a newly appreciated type of T cells: T helper type 17 (Th17) cells. Etanercept reduced the inflammatory dendritic cell products that drive Th17 cell proliferation (interleukin [IL] 23), as well as Th17 cell products and downstream effector molecules (IL-17, IL-22, CC chemokine ligand 20, and β-defensin 4). In contrast, Th1 cellular products and effector molecules (interferon γ, lymphotoxin α, and myxovirus resistance 1) were reduced late in disease resolution. This study suggests a role for Th17 in addition to Th1 cells in the pathogenesis of psoriasis. Th17 cells may be particularly important in driving epidermal activation in psoriatic plaques, whereas Th1 cells must also be eliminated for final disease resolution.
A Multilevel Knowledge Representation of Strategies for Combining Modules 1 Problem Area and Goal

The research was motivated by the need to represent knowledge (when written in Prolog) in a way that would retain its inherent structure. Our approach attempts to ooer means of abstraction for structuring logic programs according to both generality levels and to knowledge content, i.e. meta-levels. Using the notion of a modular logic program, we deene a special reeection mechanism which establishes connections between modules at a given level and a level above. We describe various ways of combining of modules. We propose deening meta-knowledge in separate modules, with each module deening one particular strategy. Another option is dividing meta-knowledge that deenes one strategy into several modules at one level, and deening a way of combining them. Despite several widely recognized advantages of logic programming such as declarative semantics, or mechanisms of uniication and deduction, the extent of its suitability for development of large software systems is relatively limited. One of the crucial problems is the lack of concepts, and consequently of language constructs, for structuring programs, modularity, sharing and hiding, etc. All of them are important means to manage complexity of software. The need to structure logic programs is motivated also by another perspective. Logic programming is a paradigm which is suitable to writing programs that embody the relevant problem knowledge written in a form that is close to the one in which it is expressed by human experts. However, the knowledge pieces are frequently related to each other according to various properties: some of them can be more general than some others, some can deene ways how to evaluate, select, or manipulate other ones, etc. It would be very useful to keep such relations represented in the knowledge base. Less general knowledge pieces could inherit some of the properties of the more general ones without having to re-represent them. Knowledge pieces that manipulate other pieces could be grouped to form an explicit meta-level of knowledge representation. The desire to have in a logic programming language such as Prolog means a
Effective web video clustering using playlist information

The spread of video sharing services has made available an enormous number of videos. Even when searching video sharing services, too many videos are returned to view. Viewers want to classify videos to easily grasp results, because videos may include varied topics or differing viewpoints. Video clustering is one solution to addressing this problem with many related approaches to research. However, existing approaches have problems: text information in metadata tends to be of low quality, visual information is difficult to analyze, and some information on user viewing behavior includes noise. This paper focuses on playlist information, which is a type of user viewing behavior. A playlist is useful because it is based on the viewers' knowledge or intuitiveness; beyond that, it is not noisy. We propose the playlist-based video clustering method (PVClustering), a novel framework that can form new clusters independent of text or visual similarities. The proposed method is computationally inexpensive and language-independent. By our method, users can grasp the outline of search result videos in a new light. Our experiments show good result clusters generated by PVClustering and prove that it can capture relativity or proximity among videos, which is not coded in text information. They also present the characteristics of PVClustering.
Experiment Report on the Implementation of Agile Testing

The process of software testing in agile environments presents complexity due to the need to be performed at short time intervals. Currently, there is no consensus in literature of the best approach to deploy agile testing. The testing management is often one of the hardest steps to be adapted to these methods, due to the short time for deliveries, which reduces the time available for testing, as a result, it is usually relegated to the background. In order to assess the viability and possible benefits in the implementation of an agile testing process, an exploratory research was made on the deployment approaches of agile testing, successfully used in different contexts and some of these approaches have been implemented in a software development company, which uses principles of agile methods.
2016 Fifth International Conference on Recent Trends in Information Technology Contrast Enhancement of Satellite Images Using Advanced Block Based Dwt Technique

—This paper sets forth enhancement of satellite portrait using advanced block based Discrete Wavelet Transform Technique. The contrast enhancement method uses the analysis of preeminent glaze levels and suitable flexible radiant transfiguration which performs DWT in reducing the rate of image which is given as input, into a group of band bounded constituents by a sampling factor, called High-High, High-Low, Low-High, and Low-Low sub bands. The brilliance propaganda is contained in the Low-Low sub-band where the input image with the preeminent glaze level is computed. According to the preeminent glaze level the Low-Low sub band is disintegrated into trilayer. The suitable flexible radiant transfiguration is processed in the disintegrated trilayer of the sub-band using knee shift function, dominant glaze level and gamma adjustment function. For preserving the texture of contrast suitable enhanced flexible radiant transfiguration is processed. The final enhanced image is acquired by means of the use of inverse DWT. In this method, the distant sensed image is bifurcated into petite blocks, and then each block is improvised using advanced block based discrete wavelet transform. The enhanced blocks are then fused together and by using inverse DWT, the emanated image is obtained. The glaze and radiance of the satellite image will be better when compared with the image used in the Existing systems. Haar Wavelet Transform (HWT) is used for disintegrating the pictures into sub-bands. Trilayer is formed using preeminent glaze level analysis. From the preeminent glaze, each disintegrated layer there is a generation of suitable radiance transfer function.
Adaptive synchronization of multi-agent systems with unknown nonlinear dynamics

In this paper, we consider the adaptive synchronization problem for multi-agents systems with unknown nonlinear dynamics. The topologies of the networks are switching. A novel adaptive synchronization algorithm is proposed by using linear parameterizations of unknown nonlinear dynamics of all agents. By stability analysis and parameter convergence analysis of the proposed algorithm, adaptive synchronization can be realized based on neighboring graphs. The stability analysis is based on algebraic graph theory and Lyapunov theory, the PE condition plays a key role in parameter convergence analysis. Example is given to validate the theoretical results.
Order-Optimal Rate of Caching and Coded Multicasting With Random Demands

We consider the canonical <italic>shared link caching network</italic> formed by a source node, hosting a library of <inline-formula> <tex-math notation="LaTeX">$m$ </tex-math></inline-formula> information messages (files), connected via a noiseless multicast link to <inline-formula> <tex-math notation="LaTeX">$n$ </tex-math></inline-formula> user nodes, each equipped with a cache of size <inline-formula> <tex-math notation="LaTeX">$M$ </tex-math></inline-formula> files. Users request files independently at random according to an a-priori known demand distribution q. A coding scheme for this network consists of two phases: cache placement and delivery. The cache placement is a mapping of the library files onto the user caches that can be optimized as a function of the demand statistics, but is agnostic of the actual demand realization. After the user demands are revealed, during the delivery phase the source sends a codeword (function of the library files, cache placement, and demands) to the users, such that each user retrieves its requested file with arbitrarily high probability. The goal is to minimize the average transmission length of the delivery phase, referred to as <italic>rate</italic> (expressed in channel symbols per file). In the case of deterministic demands, the optimal min-max rate has been characterized within a constant multiplicative factor, independent of the network parameters. The case of random demands was previously addressed by applying the order-optimal min-max scheme separately within groups of files requested with similar probability. However, no complete characterization of order-optimality was previously provided for random demands under the average rate performance criterion. In this paper, we consider the random demand setting and, for the special yet relevant case of a Zipf demand distribution, we provide a comprehensive characterization of the order-optimal rate for all regimes of the system parameters, as well as an explicit placement and delivery scheme achieving order-optimal rates. We present also numerical results that confirm the superiority of our scheme with respect to previously proposed schemes for the same setting.
Mutations of intermediate effect are responsible for adaptation in evolving Pseudomonas fluorescens populations

The fixation of a beneficial mutation represents the first step in adaptation, and the average effect of such mutations is therefore a fundamental property of evolving populations. It is nevertheless poorly characterized because the rarity of beneficial mutations makes it difficult to obtain reliable estimates of fitness. We obtained 68 genotypes each containing a single fixed beneficial mutation from experimental populations of Pseudomonas fluorescens, evolving in medium with serine as the sole carbon source and estimated the selective advantage of each by competition with the ancestor. The distribution of selection coefficients is modal and closely resembles the Weibull distribution. The average selection coefficient (2.1) and beneficial mutation rate (3.8×10−8) are high relative to previous studies, possibly because the ancestral population grows poorly in serine-limited medium. Our experiment suggests that the initial stages of adaptation to stressful environments will involve the substitution of mutations with large effect on fitness.
Achieving control of in-plane elastic waves

We derive the elastic properties of a cylindrical cloak for in-plane coupled shear and pressure waves. The cloak is characterized by a rank 4 elasticity tensor with spatially varying entries, which are deduced from a geometric transform. Remarkably, the Navier equations retain their form under this transform, which is generally untrue [G. W. Milton et al., N. J. Phys. 8, 248 (2006)]. The validity of our approach is confirmed by comparison of the analytic Green’s function in homogeneous isotropic elastic space against full-wave finite element computations in a heterogeneous anisotropic elastic region surrounded by perfectly matched layers.
DASCh: Dynamic Analysis of Supply Chains

Modern manufacturing is moving away from vertically integrated companies that control all aspects of production and distribution, toward networks of independent suppliers and distributors. These supply networks (more commonly called “supply chains”) address a number of business needs, including concentration on core competencies and the ability to respond rapidly to unanticipated change. However, they present significant operational challenges. Many of these challenges are driven by the dynamical behavior of the supply chain as its members interact with one another. Data analytic approaches are not effective in understanding these dynamics, because the commercial environment changes too rapidly to permit the collection of consistent data series long enough to support statistical requirements. DASCh takes the approach of constructing and experimenting with an agent-based emulation model of the system that can maintain a given set of conditions as long as desired.
Le discernement. Une approche casuistique des énoncés d’opinion publique

A partir de l’analyse d’un corpus de reponses a des questions ouvertes de sondage, cet article rend compte de ce qui apparait entre 2009 et 2013, comme un repli des enonces stigmatisant la consommation excessive d’energie dans le public. Nous nous interessons notamment a des enonces de discernement, enonces tirant de l’examen des conditions d’exercice concret de la norme des raisons legitimes de differer ou d’amenager son application.
3 Capital Allocation with CreditRisk +

Capital allocation for credit portfolios has two meanings. First, at portfolio level it means to determine capital as a buffer against an unexpected negative cash-flow resulting from credit losses. In this case, the allocation method can be specified by means of a risk measure. Its result is called economic capital of the portfolio. Second, at sub-portfolio or transaction level, capital allocation means breaking down the economic capital of the portfolio to its sub-units. The resulting capital assignments are called risk contributions. We discuss several current concepts for economic capital and risk contributions in a general setting. Then we derive formulas and algorithms for these concepts in the special case of the CreditRisk methodology with individual independent potential exposure distributions.
Enhancement of QoE in Audio-Video IP Transmission by Utilizing Tradeoff between Spatial and Temporal Quality for Video Packet Loss

This paper proposes a methodology of video-stream output at the receiver for enhancing QoE (quality of experience) in audio-video IP transmission. The methodology copes with video packet loss by error concealment and/or video frame skipping; it utilizes the tradeoff relation of QoE between spatial and temporal quality caused by the two techniques. As a simple example of the methodology, we adopt a scheme which switches between the two techniques according to the percentage of video slices error-concealed in a frame; the scheme is referred to as SCS (switching between error concealment and frame skipping). We conducted experiments on the SCS with six contents. Taking into consideration the cross-modal interaction between audio and video, we then assessed QoE in terms of the psychological scale, which is more accurate than MOS (mean opinion score). The experimental result shows that the SCS can improve QoE over the simple error concealment or frame skipping by selecting an appropriate threshold value of the error concealment ratio, which depends on the content type, video picture pattern and degree of video motion.
Bactericidal antibiotics induce programmed metabolic toxicity

The misuse of antibiotics has led to the development and spread of antibiotic resistance in clinically important pathogens. These resistant infections are having a significant impact on treatment outcomes and contribute to approximately 25,000 deaths in the U.S. annually. If additional therapeutic options are not identified, the number of annual deaths is predicted to rise to 317,000 in North America and 10,000,000 worldwide by 2050. Identifying therapeutic methodologies that utilize our antibiotic arsenal more effectively is one potential way to extend the useful lifespan of our current antibiotics. Recent studies have indicated that modulating metabolic activity is one possible strategy that can impact the efficacy of antibiotic therapy. In this review, we will address recent advances in our knowledge about the impacts of bacterial metabolism on antibiotic effectiveness and the impacts of antibiotics on bacterial metabolism. We will particularly focus on two studies, Lobritz, et al. (PNAS, 112(27): 8173-8180) and Belenky et al. (Cell Reports, 13(5): 968-980) that together demonstrate that bactericidal antibiotics induce metabolic perturbations that are linked to and required for bactericidal antibiotic toxicity.