Miracle-dz/UniFAR-FTUs huggingface dataset:
A Meta-Analysis on the Interaction between HER-2 Expression and Response to Endocrine Treatment in Advanced Breast Cancer

Purpose: Experimental data suggest a complex cross-talk between HER-2 and estrogen receptor, and it has been hypothesized that HER-2-positive tumors may be less responsive to certain endocrine treatments. Clinical data, however, have been conflicting. We have conducted a meta-analysis on the interaction between the response to endocrine treatment and the overexpression of HER-2 in metastatic breast cancer. Experimental Design: Studies have been identified by searching the Medline, Embase, and American Society of Clinical Oncology abstract databases. Selection criteria were (a) metastatic breast cancer, (b) endocrine therapy (any line of treatment), and (c) evaluation of HER-2 expression (any method). For each study, the relative risk for treatment failure for HER-2-positive over HER-2-negative patients with 95% confidence interval was calculated as an estimate of the predictive effect of HER-2. Pooled estimates of the relative risk were computed by the Mantel-Haenszel method. Results: Twelve studies (n = 2,379 patients) were included in the meta-analysis. The overall relative risk was 1.42 (95% confidence interval, 1.32-1.52; P < 0.00001; test for heterogeneity = 0.380). For studies involving tamoxifen, the pooled relative risk was 1.33 (95% confidence interval, 1.20-1.48; P < 0.00001; test for heterogeneity = 0.97); for studies involving other hormonal drugs, a pooled relative risk of 1.49 (95% confidence interval, 1.36-1.64; P < 0.00001; test for heterogeneity = 0.08) was estimated. A second meta-analysis limited to tumors that were either estrogen receptor positive, estrogen receptor unknown, or estrogen receptor negative/progesterone receptor positive yielded comparable results. Conclusions: HER-2-positive metastatic breast cancer is less responsive to any type of endocrine treatment. This effect holds in the subgroup of patients with positive or unknown steroid receptors.
In Acute Ischemic Stroke, Are Asymptomatic Intracranial Hemorrhages Clinically Innocuous?

Background— In patients with acute ischemic stroke, intracranial hemorrhages are categorized as symptomatic or asymptomatic based on the presence or absence of a clinically detectable neurological deterioration. Asymptomatic intracranial hemorrhages are believed by many to be clinically innocuous. We examined whether the occurrence of an asymptomatic intracranial hemorrhage affects functional outcome in patients with acute ischemic stroke (AIS) treated or not treated with recombinant tissue plasminogen activator (rt-PA). Methods— We combined data from the NINDS rt-PA Stroke Trial and the ATLANTIS Trials, excluding patients with symptomatic intracranial hemorrhage (n=1193). We used generalized estimating equations to test whether asymptomatic intracranial hemorrhage altered the likelihood of a normal or near-normal outcome at 90 days, as measured across 4 commonly used functional outcome scales, controlling for other variables that affect outcome. To look at additional outcomes, including the likelihood of disability and death, we used logistic regression equations. Additionally, we systematically reviewed previous studies that assessed the effect of intracranial hemorrhage in AIS. Results— In the combined database, the rate of asymptomatic intracranial hemorrhage was higher in rt-PA treated than in nontreated patients (9.9% versus 4.2%, P<0.0001). Controlling for other prognostic factors, the odds of a normal or near-normal outcome was lower when a patient had an asymptomatic intracranial hemorrhage, but this effect did not reach statistical significance (OR=0.69, 95% CI: 0.43 to 1.12, P=0.13). Similarly, the odds of not being moderately to severely disabled (modified Rankin Score ≤2) was also lower for patients with asymptomatic intracranial hemorrhage (OR=0.60, 95% CI: 0.33 to 1.08, P=0.09). Despite using a larger sample than any previously published study, the power in our study to detect a 30% decrease in the odds of a good outcome was inadequate (≈32%). Conclusion— We could not confirm or exclude a clinically significant effect for asymptomatic intracranial hemorrhages based either on our analysis or on any previously published trial. Analysis of substantially larger databases are needed to assess the import of this common clinical event.
Effect of adding fat and(or) milk products to the weanling pig diet on performance in the nursery and subsequent grow-finish stages.

Six experiments were conducted to evaluate the use of fat in diets containing a high level of milk products for weanling pigs. In Exp. 1, 192 pigs (6.6 kg and 23 d) were used to determine whether milk products (0 or 40%) in the diet influenced the utilization of fat (0 or 10%). No fat x milk product interactions were found. Adding milk products to the diet improved (P < .01) ADG, ADFI, and gain/feed (G/F). Adding fat to the diet did not influence performance. In Exp. 2, 3, and 4, 576 pigs (6.0 kg and 20 d) were used to determine the influence of fat level on performance. Adding soybean oil (0, 3, 6, or 9%) to the diet from d 0 to 14 after weaning had no influence on growth performance. Increasing soybean oil (0, 2, 4, or 6%) in the diet from d 14 to 35 had no influence on ADG; however, G/F improved linearly (P < .001). In Exp. 5, 196 pigs (7.5 kg and 26 d) were used to determine the influence of fat source (soybean oil, corn oil, or tallow) on performance. Pig performance was not different among fat sources. In Exp. 6, 240 pigs (5.4 kg and 21 d) were used to determine the influence of fat and(or) milk product inclusion in the nursery diet on subsequent grow-finish performance. Adding milk products, but not fat, to the nursery diet improved (P < .08) overall performance to market weight. These results indicate adding fat to the diet from d 0 to 14 after weaning had no influence on performance. Adding fat to the diet from d 14 to 35 improved G/F; however, it did not improve ADG or overall performance to market. Diet composition during the nursery period can affect subsequent performance.
Optimizing Power Consumption in Large Scale Storage Systems

Data centers are the backend for a large number of services that we take for granted today. A significant fraction of the total cost of ownership of these large-scale storage systems is the cost of keeping hundreds of thousands of disks spinning. We present a simple idea that allows the storage system to turn off a large fraction of its disks, without incurring unacceptable performance penalties. Of particular appeal is the fact that our solution is not application-specific, and offers power-savings for a very generic data center model. In this paper, we describe our solution, identify the parameters that determine its cost-benefit tradeoffs, and present a simulator that allows us to explore this parameter space. We also present some initial simulation results that add weight to our claim that our solution represents a new power-saving opportunity for large-scale storage systems.
A Formal Characterization of Concept Learning in Description Logics

Among the inferences studied in Description Logics (DLs), induction has been paid increasing attention over the last decade. Indeed, useful non-standard reasoning tasks can be based on the inductive inference. Among them, Concept Learning is about the automated induction of a description for a given concept starting from classified instances of the concept. In this paper we present a formal characterization of Concept Learning in DLs which relies on recent results in Knowledge Representation and Machine Learning.
BER performance analysis for HSDPA with MIMO — SBCE predictors

This paper gives an overview of recent advancements in multiple-input multiple-output (MIMO) systems under W-CDMA to increase the system performance and Spectral efficiency. We investigate the effects of predicting the CSI using linear fading envelope predictors under AWGN and Multipath Rayleigh fading by considering Semi- blind channel schemes in Spatial multiplexing and STBC to enhance the performance of an ACM system. The evaluation of the channel performance is done with BER.
Characteristics of Escherichia coli isolated from broiler chickens with colibacillosis in commercial farms from a common hatchery

&NA; To investigate the epidemiologic aspects of colibacillosis in broiler chickens, 83 Escherichia coli isolates obtained from the pericarditis and perihepatitis lesions in broiler chickens from 4 commercial farms, 5 isolates recovered from 5 samples of yolk sac contents that were pooled from 25 emaciated chicks, and 4 fecal isolates obtained from a hatchery that supplied chicks to the 4 commercial farms mentioned above were genetically and bacteriologically characterized. Using pulsed‐field gel electrophoresis (PFGE), a total of 92 isolates were classified into 33 pulsotypes. Identical pulsotypes were observed in isolates obtained from hatchery samples and the affected broiler chickens on multiple farms at various sampling times. Seventeen representative isolates with no common origin belonging to 6 pulsotypes and an additional 27 isolates with the other pulsotypes were used for further experiments. Isolates with identical pulsotypes exhibited common traits for virulence‐associated genes, lipopolysaccharide core types, and phylogenetic groups. Nine of the isolates were serologically typed as O125 with various types of H antigens and 3 were typed as O25:H4. In the 27 isolates resistant to ceftiofur (CTF), which is a third generation cephalosporin, the blaCTX‐M‐2, blaCMY‐2, blaCTX‐M‐14, blaCTX‐M‐65 genes were found in 15, 8, 3, and 1 isolate(s), respectively, and another isolate resistant to CTF had both the blaCTX‐M‐2 and the blaCMY‐2 genes. In the 16 isolates with the blaCTX‐M‐2 gene, the chromosomal location of the gene was identified in 12 isolates. The plasmid‐mediated quinolone resistance genes, oqxAB and aac(6')‐Ib‐cr, were found in 2 and 3 isolates, respectively. Conjugation experiments revealed that the blaCTX‐M‐2 (4 isolates), blaCTX‐M‐14 (3 isolates), blaSHV‐12 (1 isolate), and oqxAB (2 isolates) genes were transferred. Our data suggest that E. coli strains with identical pulsotypes had been caused the incidences of colibacillosis and that the antimicrobial resistance genes on conjugative plasmids and those integrated into the chromosome may be spread among avian pathogenic E. coli strains in multiple farms.
Apolipoprotein E gene polymorphism, total plasma cholesterol level, and Parkinson disease dementia.

BACKGROUND Apolipoprotein E gene (APOE) polymorphism is an important determinant for the development of various cardiovascular and neurodegenerative disorders. There have been conflicting reports of association of APOE polymorphism with dementia in Parkinson disease (PD). OBJECTIVE To determine the relationship between APOE polymorphisms and plasma cholesterol concentration, and PD with dementia (PDD). DESIGN Four-year (1999-2002) case-control study. SETTING Academic medical center with inpatient and outpatient movement disorders services. Patients Consecutive white patients of the same ethnic background with PD. INTERVENTIONS Strict clinical, neuropsychological, and neuroimaging criteria were used to exclude dementia with Lewy bodies, Alzheimer disease, and vascular dementia. Findings were compared in 2 clinical groups, including 98 patients (47 men and 51 women; mean age, 71 years) with PDD and 100 patients (52 men and 48 women; mean age, 62 years) with PD without dementia. MAIN OUTCOME MEASURES Analysis of APOE genotypes and allelic frequency (polymerase chain reaction) and plasma cholesterol concentration (enzymatic assay) were evaluated by a clinician blinded to the clinical diagnosis, and findings were compared between the groups with PDD or PD without dementia. Multiple stepwise regression analysis and the Spearman rank correlation coefficient were used to evaluate relationships between dementia and both APOE polymorphism and cholesterol concentration. Statistical significance was set at P<. 05. RESULTS Epsilon4 allele frequencies were similar in PDD and PD without dementia (16.8% vs 19%, respectively). Cholesterol concentration, APOE genotypes, and allelic frequencies did not relate to PDD. CONCLUSIONS In contrast to Alzheimer disease, when PDD is carefully defined, it is clearly not associated with APOE polymorphisms or with a distinctive plasma cholesterol profile. Ongoing longitudinal follow-up with emphasis on autopsy recruitment will enable further analyses of biochemical alterations underlying PDD.
A Synchronous Model for Multi-Party Computation and the Incompleteness of Oblivious Transfer

This work develops a composable notion of security in a synchronous communication network to analyze cryptographic primitives and protocols in a reliable network with guaranteed delivery. In such a synchronous model the abort of protocols must be handled explicitly. It is shown that a version of global bit commitment which allows to identify parties that did not give proper input cannot be securely realized with the primitives oblivious transfer and broadcast. This proves that the primitives oblivious transfer and broadcast are not complete in our synchronous model of security. In the synchronous model presented ideal functionalities as well as parties can be equipped with a “shell” which can delay communication until the adversary allows delivery or the number of rounds since the shell received the message exceeds a specified threshold. This additionally allows asynchronous specification of ideal functionalities and allows to model a network where messages are not necessarily delivered in the right order. If these latency times are chosen to be infinite the network is no more reliable and becomes completely asynchronous. It is shown that secure protocols in the setting of [Can01] or [CLOS02] can be transformed to secure realizations in the new model if latency times are chosen to
Reconfigurable signal processor for channel coding and decoding in low SNR wireless communications

An area and computational-time efficient turbo decoder implementation on a reconfigurable processor is presented. The turbo decoder takes advantage of the latest sliding window algorithms to produce a design with minimal storage requirements as well as offering the ability to configure key system parameters via software. The parameter programmability allows the decoder to be used in a research environment to study less understood aspects of turbo codes.
Analgesic and Antiinflammatory Activities of the Aqueous Extract from Plectranthus amboinicus (Lour.) Spreng. Both In Vitro and In Vivo

Plectranthus amboinicus (Lour.) Spreng. is a native Labiatae plant of Taiwan. The plants are commonly used in Chinese folk medicine for the treatment of cough, fever, sore throats, mumps, and mosquito bite. The aim of this study was to investigate the analgesic and antiinflammatory properties of the aqueous extract from Plectranthus amboinicus (PA) in vivo and in vitro. PA inhibited pain induced by acetic acid and formalin, and inflammation induced by carrageenan. The anti-inflammatory effect of PA was related to modulating antioxidant enzymes' activities in the liver and decreasing the Malondialdehyde (MDA) level and the production of tumor necrosis factor alpha (TNF-α), and cyclooxygenase2 (COX-2) in edema-paw tissue in mice. In vitro studies show that PA inhibited the proinflammatory mediators in RAW 264.7 cells stimulated with lipopolysaccharide (LPS). PA blocked the degradation of IκB-α and nuclear translocation of NF-κB p65 subunit. Finally, the amount of carvacrol in the aqueous extract of PA was 1.88 mg/g extract. Our findings suggest that PA has analgesic and anti-inflammatory activities. These effects were mediated by inhibiting the proinflammatory mediators through blocking NF-κB activation. Meanwhile, the effects observed in this study provide evidence for folkloric uses of Plectranthus amboinicus (Lour.) Spreng. in relieving pain and inflammation.
Fast GPU Implementation of Sparse Signal Recovery from Random Projections

We consider the problem of sparse signal recovery from a small number of random projections (measurements). This is a well known NP-hard to solve combinatorial optimization problem. A frequently used approach is based on greedy iterative procedures, such as the Matching Pursuit (MP) algorithm. Here, we discuss a fast GPU implementation of the MP algorithm, based on the recently released NVIDIA CUDA API and CUBLAS library. The results show that the GPU version is substantially faster (up to 31 times) than the highly optimized CPU version based on CBLAS (GNU Scientific Library).
The co-evolution of socio-technical structures in sustainable software development: Lessons from the open source software communities

Software development depends on many factors, including technical, human and social aspects. Due to the complexity of this dependence, a unifying framework must be defined and for this purpose we adopt the complex networks methodology. We use a data-driven approach based on a large collection of open source software projects extracted from online project development platforms. The preliminary results presented in this article reveal that the network perspective yields key insights into the sustainability of software development.
Dietary Factors Relate to Cardiovascular Risk Factor in Early LIfe: Bogalusa Heart Study

Relationships between diet and cardiovascular disease risk factors were studied in a cohort of infants in Bogaluse, Louisiana. The 24-hour dietary recalls and cardiovascular measurements were obtaind of each child at age 6 months, yearly through age 4, and again at age 7 (cardiovascular measurements only). At ages 4 and 7, children with persistently high intakes of dietary cholesterol (three or more measuements in the upper tertile) had levels of serum total cholesterol approximately 14 mg/dl higher than children whose intakes of cholesterol were nhot peristently high. Children in the upper tertile for dietary cholesterol had levels of low density lipoprotein cholesterol (15 mg/dl at age 4 and 18 mg/dl at age 7) higher than children in the lower tertile for dietary cholesterol. Children with high intakes of animal fat were 2 to 6 kg heavier (p < 0.05) than those with lower intakes. Changes in dietary cholesterol correlated significantly with changes in serum totalf cholesterol (r=0.42) and low density lipoprotein cholesterol (r=0.50) from 6 months to 4 years of age. Changes in subscapular skinfold measurements correlated significantly with changes in intake of total protein (r=0.31), total fat (r=0.25), starch (r=0.31), and energy (r=0.39) frp, ages 6 months to 4 years. Results indicate that tracking of dietary components and their relationships with cardfiovascular disease risk factors can be detected at an early age. These findings may well be the groundwork for later studied to obesity and the early onset of hyperlipoprotnemia.
Errorless learning and the cognitive rehabilitation of memory-impaired schizophrenic patients

Background. In recent years, evidence has accumulated that a significant proportion of schizophrenic patients have severe memory impairment, which cannot be attributed to the effects of medication, chronicity or institutionalization. Our group has demonstrated that memory impairment is associated with poor psychosocial outcome and treatment resistance. Work on the classical amnesic syndrome has suggested that memory training is facilitated by adopting an ‘errorless learning’ approach, where subjects do not experience failure during learning. This is based on the theory that the preserved implicit memory of amnesic patients results in implicitly remembered incorrect responses interfering with target items, in the absence of a functioning explicit memory system to allow differentiation. Method. We compared three groups of subjects, memory-impaired schizophrenic patients, memory unimpaired schizophrenic patients and healthy controls. Results. An errorless learning approach conferred a significant advantage on the memory-impaired schizophrenic group, bringing their performance up to the level of both control groups. In contrast, adopting a traditional trial and error, or errorful approach resulted in markedly impaired performance in the memory-impaired schizophrenic group only. Conclusions. We conclude that errorless learning approaches may be worthy of further evaluation in the cognitive rehabilitation of memory-impaired schizophrenic patients.
Reversal of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a AKT/FOXOA1 Dependent Regulation of H2S Generation and Endothelin-1

Background GPBAR1 is a bile acids activated receptor expressed in entero-hepatic tissues. In the liver expression of GPBAR1 is restricted to sinusoidal and Kuppfer cells. In the systemic circulation vasodilation caused by GPBAR1 agonists is abrogated by inhibition of cystathione-γ-liase (CSE), an enzyme essential to the generation of hydrogen sulfide (H2S), a vasodilatory agent. Portal BAR501 is a semisynthetic bile acid derivative endowed with a potent and selective agonistic activity toward GPBAR1. Methods Cirrhosis was induced in mice by carbon tetrachloride (CCL4) administration for 9 weeks. Liver endothelial dysfunction was induced by feeding wild type and Gpbar1-/- mice with methionine for 4 weeks. In both models, mice were administered BAR501, 15 mg/kg/day. Results By transactivation assay we demonstrate that BAR501 is a selective GPBAR1 agonist devoid of any FXR agonistic activity. In naïve rats, BAR501 effectively reduced hepatic perfusion pressure and counteracted the vasoconstriction activity of norepinephrine. In the CCl4 model, 9 weeks treatment with BAR501 effectively protected against development of endothelial dysfunction by increasing liver CSE expression and activity and by reducing endothelin (ET)-1 gene expression. In mice feed methionine, treatment with BAR501 attenuated endothelial dysfunction and caused a GPBAR1-dependent regulation of CSE. Using human liver sinusoidal cells, we found that modulation of CSE expression/activity is mediated by both genomic (recruitment of CREB to CRE in the CSE promoter) and non-genomic effects, involving a Akt-dependent phosporylation of CSE and endothelial nitric oxide (NO) synthase (eNOS). BAR501, phosphorylates FOXO1 and inhibits ET-1 transcription in liver sinusoidal cells. Conclusions BAR501, a UDCA-like GPBAR1 agonist, rescues from endothelial dysfunction in rodent models of portal hypertension by exerting genomic and non-genomic effects on CSE, eNOS and ET-1 in liver sinusoidal cells.