Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation and prognostic significance of ACAT1 as a marker of prostate cancer progression

Prostate cancer is the second leading cause of cancer‐related death among men in North America. While a majority of prostate cancer cases remain indolent, subsets of patients develop aggressive cancers, which may lead to death. The current methods of detection include digital rectal examination and the serum PSA test. However, due to lack of specificity, neither of these approaches is able to accurately discriminate between indolent and aggressive cancer, which is why there is a need for additional prognostic factors. Previously, we identified enzymes of the ketogenic pathway, particularly ACAT1, to be elevated in aggressive prostate cancer.
Power reduction of chip multi-processors using shared resource control cooperating with DVFS

This paper presents a novel power reduction method for chip multi-processors (CMPs) under real-time constraints. While the power consumption of processing units (PUs) on CMPs can be reduced without violating real-time constraints by dynamic voltage and frequency scaling (DVFS), the clock frequency of each PU cannot be determined independently because of the performance impact caused by the conflict for the shared resources. To minimize power consumption in this situation, we first derive an analytical model which provides the optimal priority and clock frequency setting, and then propose a method of controlling the priority of shared resource accesses in cooperation with DVFS. From the analytical model, in dual-core CMPs, we reveal that the total power consumption is minimized when the clock frequency of two PUs becomes the same. An experiment with a synthetic benchmark supports the validity of the analytical model and the evaluation results with real applications show that the proposed method reduces the power consumption by up to 15% and 6.7% on average compared with a conventional DVFS technique.
Current-Voltage Characteristics of Ungated AlGaN/GaN Heterostructures

Results of a systematic study of the current vs. voltage characteristics of ungated AlGaN/GaN heterostructures grown on sapphire substrates are presented. It is experimentally observed that the saturation current nearly doubles as the source-to-drain channel lengths decrease from 11.8 to 1.7 {micro}m. The average electric field at which current saturation occurs is 10 to 30 kV/cm, i.e. much less than the electron velocity saturation field. The experimental data is interpreted in the framework of a new model that takes into account the non-uniformity of the electron density in the channel, electron velocity saturation, and thermal effects. The temperature dependent electron transport characteristics of the model are based on Monte Carlo simulations of electron transport in GaN. It is shown that appreciable contact resistance, which leads to partial channel depletion near the source, and significant self-heating of the devices under high drain-to-source bias are the main reasons for the observed current saturation. The effective ambient temperature in the channel of the devices is calculated from a two-dimensional thermal model of heat dissipation through the sapphire substrate. Equilibrium channel carrier concentrations and low-field mobilities are determined from Hall effect data. The ungated structures are demonstrated to provide much useful materials and processmore » characterization data for the development of AlGaN/GaN heterostructure field effect transistors. « less
Strategies to prevent progression of high-risk bladder cancer at initial diagnosis

Purpose of reviewAs high-risk nonmuscle invasive bladder cancer (NMIBC) has a high propensity to recur and progress, the primary therapeutic goal in patients with high-risk NMIBC is the prevention or delay of disease recurrence and progression. Recent findingsFor improving transurethral resection quality, new optical enhancement technology such as optical coherence tomography, photodynamic diagnosis and narrow band imaging might be considered because these emerging optical techniques may contribute to resection completeness and reduce the recurrence risk. Recent studies have confirmed that a second resection is associated with a lower risk of progression and cancer-related death. Although maintenance bacillus Calmette-Guérin (BCG) for at least 1 year has been recommended, some studies have shown no significant advantage to maintenance BCG. Although other options may be considered in early BCG failure, there are no large trials that have shown a long-term benefit in BCG-failure patients. SummaryCurrent literature suggests that the best treatment for patients with high-risk NMIBC involves complete transurethral resection with intravesical BCG therapy. New approaches or therapeutic agents for preventing recurrence and progression are needed in this field.
The effect of scene context on episodic object recognition: Parahippocampal cortex mediates memory encoding and retrieval success

Previous research has investigated intentional retrieval of contextual information and contextual influences on object identification and word recognition, yet few studies have investigated context effects in episodic memory for objects. To address this issue, unique objects embedded in a visually rich scene or on a white background were presented to participants. At test, objects were presented either in the original scene or on a white background. A series of behavioral studies with young adults demonstrated a context shift decrement (CSD)—decreased recognition performance when context is changed between encoding and retrieval. The CSD was not attenuated by encoding or retrieval manipulations, suggesting that binding of object and context may be automatic. A final experiment explored the neural correlates of the CSD, using functional Magnetic Resonance Imaging. Parahippocampal cortex (PHC) activation (right greater than left) during incidental encoding was associated with subsequent memory of objects in the context shift condition. Greater activity in right PHC was also observed during successful recognition of objects previously presented in a scene. Finally, a subset of regions activated during scene encoding, such as bilateral PHC, was reactivated when the object was presented on a white background at retrieval. Although participants were not required to intentionally retrieve contextual information, the results suggest that PHC may reinstate visual context to mediate successful episodic memory retrieval. The CSD is attributed to automatic and obligatory binding of object and context. The results suggest that PHC is important not only for processing of scene information, but also plays a role in successful episodic memory encoding and retrieval. These findings are consistent with the view that spatial information is stored in the hippocampal complex, one of the central tenets of Multiple Trace Theory. © 2007 Wiley‐Liss, Inc.
Do Summaries Help? A Task-Based Evaluation of Multi-Document Summarization

We describe a task-based evaluation to determine whether multi-document summaries measurably improve user performance when using online news browsing systems for directed research. We evaluated the multi-document summaries generated by Newsblaster, a robust news browsing system that clusters online news articles and summarizes multiple articles on each event. Four groups of subjects were asked to perform the same time-restricted fact-gathering tasks, reading news under different conditions: no summaries at all, single sentence summaries drawn from one of the articles, Newsblaster multi-document summaries, and human summaries. Our results show that, in comparison to source documents only, the quality of reports assembled using Newsblaster summaries was significantly better and user satisfaction was higher with both Newsblaster and human summaries.
Discovery and Characterization of Vicriviroc (SCH 417690), a CCR5 Antagonist with Potent Activity against Human Immunodeficiency Virus Type 1

ABSTRACT Inhibiting human immunodeficiency virus type 1 (HIV-1) infection by blocking the host cell coreceptors CCR5 and CXCR4 is an emerging strategy for antiretroviral therapy. Currently, several novel coreceptor inhibitors are being developed in the clinic, and early results have proven promising. In this report, we describe a novel CCR5 antagonist, vicriviroc (formerly SCH-D or SCH 417690), with improved antiviral activity and pharmacokinetic properties compared to those of SCH-C, a previously described CCR5 antagonist. Like SCH-C, vicriviroc binds specifically to the CCR5 receptor and prevents infection of target cells by CCR5-tropic HIV-1 isolates. In antiviral assays, vicriviroc showed potent, broad-spectrum activity against genetically diverse and drug-resistant HIV-1 isolates and was consistently more active than SCH-C in inhibiting viral replication. This compound demonstrated synergistic anti-HIV activity in combination with drugs from all other classes of approved antiretrovirals. Competition binding assays revealed that vicriviroc binds with higher affinity to CCR5 than SCH-C. Functional assays, including inhibition of calcium flux, guanosine 5′-[35S]triphosphate exchange, and chemotaxis, confirmed that vicriviroc acts as a receptor antagonist by inhibiting signaling of CCR5 by chemokines. Finally, vicriviroc demonstrated diminished affinity for the human ether a-go-go related gene transcript ion channel compared to SCH-C, suggesting a reduced potential for cardiac effects. Vicriviroc represents a promising new candidate for the treatment of HIV-1 infection.
On the critical density associated with the matrix type knapsack cryptosystem

The knapsack cryptosystem invented by Merkle and Hellman and most of its variants have already been broken. The method by Lagarias and Odlyzko, known as the low density attack, is a powerful tool for attacking knapsack cryptosystems. No successful attack, however, has been reported against the matrix type knapsack system. We derive the critical density associated with this system and show some results of computer experiments of attack.
Laermometer: a mobile noise mapping application

Creating noise maps is a complex task. They can be created using modeling approaches that take into account different data such as traffic conditions and the like. Another approach is to use stationary recording stations which provide better results but are costly to maintain. Nevertheless, the benefits of noise maps are worth the effort. Laermometer has been developed to solve the problems of creating noise maps by utilizing mobile phones and their built-in microphones. The main functionality is to provide noise information for any place in the world. Users can add further information like a noise description or comments about the location and its sound level. Every user can view the noise maps and comments, anywhere using their mobile devices. In addition Laermometer brings along a small web interface. With this web interface users can view/edit their profiles, comments and noise descriptions.
Broken Symmetries and the Masses of Gauge Bosons

In a recent note' it was shown that the Goldstone theorem, ' that Lorentz-covaria. nt field theories in which spontaneous breakdown of symmetry under an internal Lie group occurs contain zero-mass particles, fails if and only if the conserved currents associated with the internal group are coupled to gauge fields. The purpose of the present note is to report that, as a consequence of this coupling, the spin-one quanta of some of the gauge fields acquire mass; the longitudinal degrees of freedom of these particles (which would be absent if their mass were zero) go over into the Goldstone bosons when the coupling tends to zero. This phenomenon is just the relativistic analog of the plasmon phenomenon to which Anderson' has drawn attention: that the scalar zero-mass excitations of a superconducting neutral Fermi gas become longitudinal plasmon modes of finite mass when the gas is charged. The simplest theory which exhibits this behavior is a gauge-invariant version of a model used by Goldstone' himself: Two real' scalar fields y„y, and a real vector field A interact through the Lagrangian density
"Baby" red cells to the rescue.

The lack of availability of a reliable assay system for culturing of Plasmodium vivax parasites ex vivo has been a major impediment to furthering our understanding of an important human parasitic disease. In this issue of Blood, Russell and colleagues outline an ex vivo invasion assay of human reticulocytes by P vivax.1
5533 - A COUPLED ELASTO-PLASTIC MICROPORE DAMAGE MODEL FOR LOW CYCLE FATIGUE ANALYSES OF DUCTILE METALS AT FINITE STRAINS

The present paper is concerned with the modeling of low-cycle fatigue of ductile metals at high stress levels. Two models, characterized by a combination of micropore damage models with an elasto-plastic material model incorporating isotropic and kinematic hardening at finite strains are investigated. Phenomena associated with cyclic plasticity such as the Bauschinger-effect, ratcheting or mean stress relaxation, cyclic hardening or softening as well as the accumulation of microdamage are considered in the coupled model. For the modeling of cyclic plasticity, a superposition of several kinematic hardening laws according to Armstrong-Frederick is employed. The modeling of damage accumulation under cyclic loading is based on the classical micropore models by Gurson and Rousselier. Both micropore damage models are extended to cyclic loading and to combined isotropic and kinematic hardening using concepts proposed by Leblond et al. Both micropore damage models differ fundamentally in the functional relationship associated with the hydrostatic stress term in the yield conditions. In the paper, the performance of both coupled models in cyclic uniaxial loading is investigated by means of a numerical benchmark example.
Workshop Characteristics Related to Chronic Disease Self-Management Education Program Attendance

Using the national dissemination of Chronic Disease Self-Management Education (CDSME) programs, the purposes of this study were to (1) document intervention attendance rates as related to the number of participants enrolled in the workshop and (2) compare the relationship between workshop attendance and workshop size by delivery site rurality and type. Data were analyzed from the first 100,000 middle-aged and older adults who participated in CDSME workshops spanning 45 states, Puerto Rico, and the District of Columbia as part of the American Recovery and Reinvestment Act of 2009 Communities Putting Prevention to Work: Chronic Disease Self-Management Program initiative. Descriptive statistics are reported for all participants, then separately by each delivery site type. Ratios between the number of workshop participants and the number of workshop sessions attended were calculated and graphed based on the rurality of delivery and separately for the leading five delivery site types. Associations between the number of workshop participants and the number of sessions attended differed by delivery site rurality and type. Findings have implications for participant retention and workshop delivery costs, which can assist program deliverers to strategically plan implementation efforts in their areas.
Color Velocity Imaging: Introduction to a New Ultrasound Technology

Noninvasive ultrasound is the preferred methodology for the initial evaluation of carotid atherosclerosis. Since the early use of continuous‐wave Doppler to assess carotid artery flow velocity blindly, neurosonology has progressed through crude B‐mode imaging, spectral analysis of the Doppler signal, and gray‐scale duplex Doppler/B‐mode imaging, to color‐flow Doppler duplex imaging. The latter allows color coding of Doppler data based on the velocity of blood flow. The combination of color‐flow Doppler with gray‐scale B‐mode imaging allows simultaneous visual display of anatomical and hemodynamic information. Physical limitations of color‐flow duplex Doppler imaging may affect the clinical utility of these techniques. Problems with pulse repetition frequency, aliasing, resolution capability of the color data, and interpolation of data make some applications difficult. Color velocity imaging uses the data contained in the gray‐scale B‐mode image scan lines to determine velocity of blood flow, and it offers potential advantages over conventional color‐flow duplex Doppler for the assessment of carotid atherosclerosis and hemodynamics. Initial comparison of spectral Doppler and color velocity imaging data suggests that the latter is an accurate method to assess blood flow velocity. Understanding of the validity, utility, and prognostic advantages offered by color velocity imaging awaits careful prospective clinical studies.
Multiplexed measurements of immunomodulator levels in peripheral blood of healthy subjects: Effects of analytical variables based on anticoagulants, age, and gender

Multiplex microbead immunoassay (MMIA) is a powerful technology for a wide range of biomedical and clinical applications. It is important to study the normal concentration ranges of immunomodulators under different sample preparation conditions and age groups of subjects in order to more precisely determine their reference values for use in assessing alterations of their levels in disease. The aim of this study was to determine the plasma concentrations of immunomodulators (cytokines, chemokines, and growth factors) in the peripheral blood from healthy subjects by the use of a large multiplex panel, and to determine the effects of different anticoagulants, age, and gender on the immunomodulator levels. In addition, the assay precision for these biomarker analytes was determined. Plasma samples from 107 healthy subjects, aged 18 to 85 years, were collected in three different anticoagulants (sodium citrate, EDTA, Heparin); corresponding serum samples were also obtained. Multiplex microbead immunoassays were performed for measuring a total of 23 analytes including chemokines, cytokines, and growth factors (IL‐1β, IL‐1ra, IL‐2, IL‐6, IL‐7, IL‐8, IL‐12 p70, IL‐17, IFN‐γ, IP‐10, MCP‐1, PDGF‐BB, RANTES, TNF‐α, IL‐1a, IL‐16, HGF, MIG, TNF‐β, PDGF‐ABBB, EGF, Flt‐3 Ligand, VEGF). For these analytes, our results showed that the anticoagulant affected the concentration measurements and the coefficients of variation. However, the relative levels of the analytes (profiles) of samples collected in a particular anticoagulant are consistent. The analytes IL‐1β, IL‐7, Flt‐3 Ligand, and IL‐12p70 show the largest variation (up to fourfold) between the age groups. In addition, no statistically significant differences in the level of the analytes were found between the sexes. © 2013 International Clinical Cytometry Society
Current Debates in Antiphospholipid Syndrome: The Acquired Antibody-Mediated Thrombophilia

Antiphospholipid (APL) syndrome is the most common form of acquired thrombophilia. It can cause significant morbidity and even mortality. The term “APL antibodies” represents a heterogeneous group of antibodies associated with this disorder. Currently no single assay can identify every APL antibody. Clinically relevant APL antibodies are mainly anticardiolipin antibodies (ACA) detected by solid phase enzyme-linked immunosorbent assay (ELISA) and lupus anticoagulants (LA) demonstrated by in vitro coagulation assay. However, there are some other antibodies associated with the APL syndrome (i.e., subgroup APL antibodies). ACAs, LAs, and subgroup APL antibodies represent intersecting, but non-identical, subsets of autoantibodies. Thus, those autoantibodies may coexist or may occur independently. Any organ system and any size of vessel can be affected during the clinical course of the disease. Therefore, the APL syndrome can manifest itself in a wide variety of clinical thrombotic features. Fetal loss and pregnancy morbidity represent a specific challenge. Despite tremendous advances in the understanding of the pathogenesis of APL syndrome during the past decade, the mainstay of management is still anticoagulation. However, there is no general agreement regarding the duration and intensity of anticoagulant therapy. In this review, we focused on the current dilemmas and their present clarifications in the wide clinicopathologic spectrum of APL syndrome and APL antibody-related distinct pathologic conditions.
Expression of Bcl-2, Bax, and p53 proteins in carcinogenesis of squamous cell lung cancer.

BACKGROUND Apoptosis is regulated by many genes, including bcl-2, p53, and bcl-2 family genes. The expression of Bcl-2, p53, and Bax in very early lung cancers or precancer lesions is not been fully understood. MATERIALS AND METHODS The expression of these proteins was examined immunohistochemically in 11 normal bronchial epithelia, 23 dysplasias, and 40 roentgenographically occult squamous cell lung cancers (ROCs). RESULTS The expression of the Bcl-2 and p53 protein increased along with the advance of the morphological atypia in bronchial epithelial cells, whereas no difference in the Bax expression. The patients with Bcl-2 positive ROCs had a better prognosis than those with Bcl-2 negative ROCs. CONCLUSIONS Bcl-2 and p53 proteins play important roles in early steps of carcinogenesis in squamous cell lung cancer of central type. The Bcl-2 protein could be a prognostic marker in ROCs.
Establishment of a first-line second-line treatment model for human pulmonary adenocarcinoma

Lung cancer is one of the most prevalent types of cancer in the world. Surgery, chemotherapy and radiotherapy are used clinically as treatments for numerous cancers. Due to the appearance of drug resistance, the remission rate is limited to 40–50%. Docetaxel and pemetrexed are two drugs commonly used, and their effects in single-phase cell culture are well known. From the pharmacological point of view, it appears rational to hypothesize that sequential therapy effects can show better outcomes compared with traditional single-phase experiments. Considering this, the present study aimed to establish a first-line second-line adenocarcinoma treatment model, using the combination of cisplatin with docetaxel or pemetrexed in vitro in different sequential therapy timings. To test this, the human lung cancer A549 cell line was used. The inhibitory effect was determined by adding docetaxel following treatment with cisplatin and pemetrexed (Pem-Doc group) and comparing this with a group in which pemetrexed was added subsequent to treatment with cisplatin and docetaxel (Doc-Pem group). Additionally, the differences in the gene and protein expression levels of excision repair cross-completion gene 1 (ERCC1), a gene that promotes drug resistance to cisplatin, were compared between the two groups. The present results showed that the inhibitory effect of cell proliferation in the Pem-Doc group was increased compared with that of Doc-Pem group, while the gene expression and protein levels of ERCC1 in the Pem-Doc group were decreased compared with those of Doc-Pem group. The Pem-Doc treatment plan is more effective in inhibiting cell proliferation and in lowering the expression of the ERCC1 gene. Therefore, Pem-Doc may be a more effective adenocarcinoma treatment.