Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimizing the terrestrial ecosystem gross primary productivity using carbonyl sulfide (COS) within a “two-leaf” modeling framework

Accurately modeling gross primary productivity (GPP) is of great importance in diagnosing terrestrial carbon-10 climate feedbacks. Process-based terrestrial ecosystem models are often subject to substantial uncertainties, primarily attributed to inadequately calibrated parameters. Recent attention has identified carbonyl sulfide (COS) as a promising proxy of GPP, due to the close linkage between leaf exchange of COS and carbon dioxide (CO 2 ) through their shared pathway of stomatal diffusion. However, most of the current modeling approaches for COS and CO 2 did not explicitly consider the vegetation structural impacts, i.e. the differences between the sun-shade and sunlit leaves in COS uptake. This study used 15 ecosystem COS fluxes data from 7 sites to optimize GPP estimation across various ecosystems with the Boreal Ecosystem Productivity Simulator (BEPS), which was further developed for simulating the leaf COS uptake under its state-of-the-art ‘two-leaf’ framework. Our results demonstrated the substantial improvement in GPP simulation across various ecosystems through the fusion of COS data into the ‘two-leaf’ model, with the ensemble mean of root mean square error (RMSE) for simulated GPP reduced by 18.99 % to 66.64 %. Notably, we also shed light on the remarkable identifiability of key parameters 20 within the BEPS model, including the maximum carboxylation rate of Rubisco at 25 ℃ ( 𝑉𝑉 𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑐25 ), minimum stomatal conductance ( 𝑏𝑏 𝐻𝐻 2 𝑜𝑜 ), and leaf nitrogen content ( 𝑁𝑁 𝑙𝑙𝑙𝑙𝑐𝑐𝑙𝑙 ), despite intricate interactions among COS-related parameters.
Integrated geophysical and mechanical study on the wooden structures of the ceiling of the Church of Beata Vergine Maria Assunta in Cielo

Non-destructive testing by mean of ground penetrating radar were performed on the wooden elements constituting the roofing of the Cathedral of Foggia. These measurements were related to the restoration work of the roof. Measurements campaign aimed at the assessment of the conservation status of the wooden elements of the all major and secondary elements of the truss of the nave, as well as on those main of the dome and the apse. Results show various abnormalities which correspond to nodes and/or slots. The presence of the nodes allow a rapid and accurate analysis of the electromagnetic waves velocity and the volumetric water content.
Mutating alfalfa COUMARATE 3-HYDROXYLASE using multiplex CRISPR/Cas9 leads to reduced lignin deposition and improved forage quality

Alfalfa (Medicago sativa L.) forage quality is adversely affected by lignin deposition in cell walls at advanced maturity stages. Reducing lignin content through RNA interference or antisense approaches has been shown to improve alfalfa forage quality and digestibility. We employed a multiplex CRISPR/Cas9-mediated gene-editing system to reduce lignin content and alter lignin composition in alfalfa by targeting the COUMARATE 3-HYDROXYLASE (MsC3H) gene, which encodes a key enzyme in lignin biosynthesis. Four guide RNAs (gRNAs) targeting the first exon of MsC3H were designed and clustered into a tRNA-gRNA polycistronic system and introduced into tetraploid alfalfa via Agrobacterium-mediated transformation. Out of 130 transgenic lines, at least 73 lines were confirmed to contain gene-editing events in one or more alleles of MsC3H. Fifty-five lines were selected for lignin content/composition analysis. Amongst these lines, three independent tetra-allelic homozygous lines (Msc3h-013, Msc3h-121, and Msc3h-158) with different mutation events in MsC3H were characterized in detail. Homozygous mutation of MsC3H in these three lines significantly reduced the lignin content and altered lignin composition in stems. Moreover, these lines had significantly lower levels of acid detergent fiber and neutral detergent fiber as well as higher levels of total digestible nutrients, relative feed values, and in vitro true dry matter digestibility. Taken together, these results showed that CRISPR/Cas9-mediated editing of MsC3H successfully reduced shoot lignin content, improved digestibility, and nutritional values without sacrificing plant growth and biomass yield. These lines could be used in alfalfa breeding programs to generate elite transgene-free alfalfa cultivars with reduced lignin and improved forage quality.
The Chronometric Dating and Subsistence of Late Neanderthals and Early Anatomically Modern Humans in the Central Balkans: Insights from Šalitrena Pećina (Mionica, Serbia)

Eastern Europe, particularly the Balkans, played a major role as a likely cul-de-sac for late Neanderthal survival and as a gateway to Europe for Anatomically Modern Humans (AMH) during the Middle to Upper Paleolithic transition. Despite the importance of the region, the known archaeological record during this period is still very limited, with little available site information. The recently excavated site of Šalitrena Pećina (Mionica, Serbia), south of the Danube River, contains archaeological evidence of late Mousterian, Aurignacian, and Gravettian occupations and presents an opportunity for understanding the behavior of both human populations in this eastern European region. Here we present the first radiocarbon dates for Neanderthal and AMH occupations in Serbia, as well as preliminary evidence on subsistence strategies obtained from the Mousterian and Aurignacian macrofaunal assemblages in Šalitrena Pećina. Radiocarbon dates indicate that Neanderthal and AMH groups may not have coexisted and interacted in this site. Nevertheless, zooarchaeological and taphonomic results show that both human populations were the main depositional agents of macrofaunal accumulation at the cave. The general compositions of the faunal assemblages reflect subtle differences between both human types and point to the necessity of further multidisciplinary research in southeastern Europe to increase our knowledge about human behavior and the causes of the demise of the Neanderthals in the Balkans.
Lower Arginine Bioavailability, Increased FeNO Levels, and Airway Resistance on Impulse Oscillometry Are Characteristics of Asthma in Children and Young Adults with Sickle Cell Disease

Background and Objectives: Data on characteristics of asthma in children with sickle cell disease (SCD) is conflicting. Recently, the L-arginine pathway has gained attention in the pathogenesis of asthma and SCD. This study aimed to determine the distinctive clinical and laboratory features and the role of arginine metabolism in asthmatic children with SCD. Materials and Methods: A total of 52 children and adolescents with SCD, including 24 with asthma (SCD-A) and 28 without asthma (SCD-NA), and 40 healthy controls were included. A questionnaire, atopy tests, fractional exhaled nitric oxide (FeNO), and lung function tests were employed. Serum metabolites of the arginine pathway were measured. The results of the three groups were compared. Results: The demographic characteristics and atopy markers of the three groups were similar. FEV1%, FEV1/FVC, MMEF%, and total lung capacity (TLC%) values of SCD-A patients were not significantly different from the SCD-NA group, but they were significantly lower than the values measured in the controls. FeNO values greater than 35 ppb were present only in the SCD-A group. In impulse oscillometry, median resistance values at 5 Hz (R5)% were higher in both SCD subgroups than in healthy controls (p = 0.001). The (R5-20/R5)% values were higher in the SCD-A group (p = 0.028). Serum arginine levels and arginine bioavailability indices were significantly lower in the SCD-A group than in the SCD-NA group and healthy controls (p = 0.003 and p < 0.001). Conclusions: Asthma in children with SCD was not associated with atopy or low FEV1/FVC levels. However, lower arginine bioavailability and higher FeNO levels differentiated asthma in patients with SCD. High R5% and (R5-20/R5)% values indicated increased airway resistance in SCD, with a predominance of small airway disease in asthmatics.
The effect of task-irrelevant objects in spatial contextual cueing

During visual search, the spatial configuration of the stimuli can be learned when the same displays are presented repeatedly, thereby guiding attention more efficiently to the target location (contextual cueing effect). This study investigated how the presence of a task-irrelevant object influences the contextual cueing effect. Experiment 1 used a standard T/L search task with “old” display configurations presented repeatedly among “new” displays. A green-filled square appeared at unoccupied locations within the search display. The results showed that the typical contextual cueing effect was strongly reduced when a square was added to the display. In Experiment 2, the contextual cueing effect was reinstated by simply including trials where the square could appear at an occupied location (i.e., underneath the search stimuli). Experiment 3 replicated the previous experiment, showing that the restored contextual cueing effect did not depend on whether the square was actually overlapping with a stimulus or not. The final two experiments introduced a display change in the last epoch. The results showed that the square does not only hinder the acquisition of contextual information but also its manifestation. These findings are discussed in terms of an account where effective contextual learning depends on whether the square is perceived as part of the search display or as part of the display background.
A Logistic Regression and Markov Chain Model for the Prediction of Nation-state Violent Conflicts and Transitions

Abstract : Using open source data, this research formulates and constructs a suite of statistical models that predict future transitions into and out of violent conflict and forecasts the regional and global incidences of violent conflict over a ten-year time horizon. A total of thirty predictor variables are tested and evaluated for inclusion in twelve conditional logistic regression models, which calculate the probability that a nation will transition from its current conflict state, either In Conflict or Not in Conflict, to a new state in the following year. These probabilities are then used to construct a series of nation-specific Markov chain models that forecast violent conflict, as well as yield insights into regional conflict trends out to year 2024 and beyond. The logistic regression models proposed in this study achieve training dataset accuracies of 88.76%, and validation dataset accuracies of 84.67%. Additionally, the Markov models achieve three year forecast accuracies of 85.16% during model validation. This study predicts that global violent conflict rates remain constant through year 2024, but are projected to increase beyond that timeframe with 95 of the 182 considered nations projected to be in a state of violent conflict from the current 84 nations in conflict.
Genetically Engineered Microorganisms and Their Impact on Human Health

The emergence of antibiotic-resistant strains, the decreased effectiveness of conventional therapies, and the side effects have led researchers to seek a safer, more cost-effective, patient-friendly, and effective method that does not develop antibiotic resistance. With progress in synthetic biology and genetic engineering, genetically engineered microorganisms effective in treatment, prophylaxis, drug delivery, and diagnosis have been developed. The present study reviews the types of genetically engineered bacteria and phages, their impacts on diseases, cancer, and metabolic and inflammatory disorders, the biosynthesis of these modified strains, the route of administration, and their effects on the environment. We conclude that genetically engineered microorganisms can be considered promising candidates for adjunctive treatment of diseases and cancers.
LIFETIME EXTENSION OF AGEING OFFSHORE STRUCTURES BY GLOBAL ULTIMATE STRENGTH ASSESSMENT (GUSA)

Malaysia is the second largest oil and gas producer in Southeast Asia. Majority of jacket platforms in Malaysia have exceeded their design life with various types of underwater structure irregularities. Therefore, it is essential to address the reliability of the jacket platforms in Malaysia due to ageing, increasing environmental loading and demand to prolong the production for a further 25 years. The main purpose of this analyses is to determine the structure’s risk level over its remaining service life which is a vital information in managing ageing facilities to cater for the demand of continuous production. Global Ultimate Strength Assessment (GUSA) methodology was used to support detailed reassessment applied in managing safety, integrity analyses and reliability by evaluating the existing platform’s loading. It is a tool for high-end analysis of structures for Risk-based Assessment (RBA). In this paper, the reassessment of an ageing platform over 30-year-old, still in production is presented to demonstrate GUSA capability to perform the platform’s life extension evaluation. The outcome from these analyses can effectively assist in understanding the structure platform’s failure mechanism and correctly identify mitigation actions required. As part of the analyses, non-linear analysis and probabilistic model as practiced in the industry were used in order to get Reserve Strength Ratio (RSR) and Annual Probability of Failure (POF) results. The accuracy and comprehensiveness of this method will assist the industry, especially oil and gas fields’ operators, in decision-making, specifically in identifying problem-oriented-solutions as part of their business risk management in managing ageing facilities.
A fluid‐rich layer along the Nankai trough megathrust fault off the Kii Peninsula inferred from receiver function inversion

Investigation of fluid distribution along megathrust faults is an important issue, since the fluid affects frictional properties and thus slip behavior on faults. Scattered teleseismic phases, or receiver functions (RFs), have made significant contributions to understanding the fluid content of subducting plates beneath the onshore regions but have been rarely applied in offshore settings. In this study, we conducted receiver function inversion analysis to investigate detailed seismic properties near the megathrust fault using ocean bottom seismometers deployed off the Kii Peninsula, southwest Japan. RFs were calculated at high frequencies (up to 4 Hz), removing the effect of water reverberations from vertical component records. Our inversion was performed in two steps: first, we modeled sediment layer by a simple stacking method and then solved for deeper structure by a waveform inversion. The results indicate the presence of a thin low‐velocity zone (LVZ) of a thickness of 0.2–1.2 km with a S wave velocity of 0.7–2.4 km/s along the plate interface. We interpret this LVZ as thin fluid‐rich sediment layer between the overriding and subducting plates that acts as a pathway of fluid migration.
Learning Multi-Granularity Task Primitives from Construction Videos for Human-Robot Collaboration

Human-robot collaboration (HRC) is an emerging solution for productivity and safety concerns in the construction sector. The seamless HRC requires robots with task awareness and explainable perception processes. However, the implicit, dynamic construction task flow and noisy visual data captured in the field pose non-trivial challenges. To address these challenges, a vision-based multi-granularity task primitive learning method is proposed. Specifically, this study seeks to enhance the mutual understanding between workers and robots by determining which granularity level is best for the tasks' understanding and whether the robot learns useful visual cues to solve the task. Results show that the intermediate level has the best compromise between classification performance and task knowledge and that the model learns both useful and useless cues to recognise task primitives. These results will increase our understanding of multi-granular worker behavior and robot perception processes. The outcomes will improve the smoothness of HRC teams.
Digital Watermarking—A Meta-Survey and Techniques for Fake News Detection

During the past few decades, research on digital media watermarking–initially designed for digital images with the envisioned applications of copyright protection or copy control– has significantly evolved with respect to other covers (i.e., video, audio, speech) and many more potential applications, including tamper detection, broadcast monitoring, and, more recently, fake news detection. As a result, various surveys have tried to summarize certain aspects of this research field as it has grown. This has led to more than 130 survey papers being written at different points in time, describing various parts of the scientific efforts focused on digital media watermarking. Considering the above, the aim of this paper is twofold. First, we conduct a meta-survey based on 64 selected research works, in order to summarize the most notable survey papers in this field, which allows us to “draw a map” of this research area. Second, we focus on providing the requirements for digital watermarking techniques when applied to their most recent application: detecting fake news in multimedia content. Finally, an outline of the approach taken within the DISSIMILAR (Detection of fake newS on SocIal MedIa pLAtfoRms) project for the detection of disinformation is presented.
Impact of melphalan day -1 vs day -2 on outcomes after autologous stem cell transplant for multiple myeloma

Background Melphalan is the most common conditioning regimen used prior to autologous stem cell transplant (ASCT); however, there are varying data on optimal melphalan timing prior to transplant for best safety and efficacy. Historically, ASCT conditioning consisted of melphalan 200 mg/m2 on day 2 (D-2) (48 h prior to ASCT), but many institutions have since adopted a melphalan protocol with administration on day 1 (D-1) (24 h prior to SCT) or split dosing over the 2 days. The optimal timing of melphalan has yet to be determined. Methods In this single-center retrospective study, we analyzed transplant outcomes for patients between March 2011 and September 2020 admitted for high-dose, single-agent melphalan 200 mg/m2 on D-1 vs. D-2. The primary outcomes were time to neutrophil and platelet engraftment. Secondary outcomes include incidence of hospital readmission within 30 days, 2-year progression-free survival, and 2-year overall survival. Results A total of 366 patients were studied (D-2 n = 269 and D-1 n = 97). The incidence of high-risk cytogenetics was similar between the two groups (37% vs. 40%). Median days to absolute neutrophil count engraftment was similar at 11 days in the D-2 and D-1 cohort (n = 269, range 0–14, IQR 11–11 vs. n = 97, range 0–14, IQR 11–12). Median days to platelet engraftment >20,000/mcL was 18 days for D-2 melphalan (range: 0–28, IQR 17–20) versus 19 days for D-1 melphalan (range: 0–32, IQR 17–21). Overall survival at 2 years post-transplant was similar in both cohorts (94%; p = 0.76), and PFS was 70% in D-2 compared with 78% in D-1 (p = 0.15). In a multivariable model including age and performance status, hospital readmission within 30 days of transplant was higher in the D-1 cohort (odds ratio 1.9; p = 0.01). Conclusion This study demonstrates similar neutrophil and platelet engraftment in D-1 and D-2 melphalan cohorts with similar 2-year PFS and OS. Either D-2 or D-1 melphalan dosing schedule is safe and effective.
Vortex localization and OAM selective conversion via cylindrical metagratings

Vortex waves with orbital angular momentum (OAM) are a highly active research topic in various fields. In this paper, we design and investigate cylindrical metagratings (CMs) with an even number of unit cells that can efficiently achieve vortex localization and specific OAM selective conversion. The multifunctional manipulation of vortex waves and the new OAM conservation law have further been confirmed through analytical calculations and numerical simulations. In addition, we qualitatively and quantitatively determine the OAM range for vortex localization and the OAM value of vortex selective conversion and also explore the stability for performance and potential applications of the designed structure. This work holds potential applications in particle manipulation and optical communication.
Environmental pharmacology: an emerging science

Every cloud has a silver lining and every rose has its thorn, drugs are no exception. Drugs have been a blessing for the mankind in curing the ailments although not completely but to a great length. Along with advantageous effects they also impart some adverse reactions sooner or later. In recent decades there is expeditious development of global pharmaceutical industry and with that an increase in consumption of pharmaceutical products. In past few years a great concern has been expressed over the occurrence and persistence of pharmaceutical products in the environment with their diverse biological effects. Human pharmaceuticals from various therapeutic classes have increasingly being detected in the environment typically at ng/L to low mcg/L in surface water. In 2009 Edward HL and others stated that there is presence of widely dispersed drugs and drug metabolites in the environment which possess a potential direct and indirect risk to humans. The pollution of water and soil bodies with pharmaceutical residues is an emerging environmental problem. Many of these substances, including human pharmaceuticals, may have little, if any, impact on human health or the environment; though for some substances there may be a significant risk.
Scale up of Microbial Fuel Cell Stack System for Residential Wastewater Treatment in Continuous Mode Operation

The most important operational expense during wastewater treatment is electricity for pumping and aeration. Therefore, this work evaluated operational parameters and contaminant removal efficiency of a microbial fuel cell stack system (MFCSS) that uses no electricity. This system consists of (i) septic tank primary treatment, (ii) chamber for secondary treatment containing 18 MFCs, coupled to an energy-harvesting circuit (EHC) that stores the electrons produced by anaerobic respiration, and (iii) gravity-driven disinfection (sodium hypochlorite 5%). The MFCSS operated during 60 days (after stabilization period) and it was gravity-fed with real domestic wastewater from a house (5 inhabitants). The flow rate was 600 ± 100 L∙d−1. The chemical oxygen demand, biological oxygen demand, total nitrogen and total phosphorous were measured in effluent, with values of 100 ± 10; 12 ± 2; 9.6 ± 0.5 and 4 ± 0.2 mg∙L−1, and removal values of 86%, 87%, 84% and 64%, respectively. Likewise, an EHC (ultra-low energy consumption) was built with 6.3 V UCC® 4700 µF capacitors that harvested and stored energy from MFCs in parallel. Energy management was programmed on a microcontroller Atmega 328PB®. The water quality of the treated effluent complied with the maximum levels set by the Mexican Official Standard NOM-001-SEMARNAT-1996-C. A cost analysis showed that MFCSS could be competitive as a sustainable and energy-efficient technology for real domestic wastewater treatment.