Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychological impact of diagnosis and risk reduction among cancer survivors

Life‐threatening health events prompt psychological distress that may motivate individuals to reduce health risks. If so, interventions timed to take advantage of these ‘teachable moments’ could be particularly effective. To explore this association, early stage prostate and breast cancer patients were identified from a hospital‐based tumor registry within 6 years of diagnosis. These patients (n=920) completed a mailed survey assessing the Horowitz impact of events scale, risk behaviors and readiness to change the behaviors. Breast cancer patients, younger patients and those reporting poor health status reported the greatest impact of the cancer diagnosis. Impact was inversely associated with time from diagnosis for prostate, but not breast cancer patients. Prostate patients who reported exercising regularly had lower impact scores than those who were not exercising (medians: 0.13 vs 0.56, respectively; p=0.02). Breast patients who were eating five or more fruits and vegetables reported lower impact scores than those who were not eating the recommended servings (0.75 vs 1.06, respectively; p=0.03). Breast patients who were non‐smokers reported lower impact scores than smokers (0.88 vs 1.31, respectively; p=0.02). Prospective studies are needed to understand the psychological impact of cancer diagnosis and how it might facilitate or impede the adoption of health promoting behaviors. Copyright © 2000 John Wiley & Sons, Ltd.
Polarization-Orthogonal Co-frequency Dual Antenna Pair Suitable for 5G MIMO Smartphone With Metallic Bezels

This paper proposes a polarization-orthogonal co-frequency dual antenna pair suitable for fifth-generation (5G) multiple-input multiple-output (MIMO) smartphone with metallic bezels. The proposed spatial-reuse dual antenna pair consists of a split on the metallic bezel and a slot on the mainboard ground, where the slot is centered on the split. Two orthogonal degenerate characteristic modes operating at half wavelength including in-phase current and slot modes can be excited on the same antenna structure. An end-shorted microstrip line that crosses the split is used to excite the in-phase current mode, producing <inline-formula> <tex-math notation="LaTeX">$y$ </tex-math></inline-formula>-polarized radiation, while a symmetrical slot-centered Y-shaped feeding network with its shorted ends crossing the slot is adopted to excite the slot mode, producing <inline-formula> <tex-math notation="LaTeX">$x$ </tex-math></inline-formula>-polarized radiation. To the best of authors’ knowledge, this is the first time that a co-frequency dual antenna pair suitable for smartphone with metallic bezels is proposed. A sub-6 GHz dual antenna pair operating at 3.5 GHz that occupies a footprint of <inline-formula> <tex-math notation="LaTeX">$25 \times 7 \times 1.5$ </tex-math></inline-formula> mm<sup>3</sup> shows a simulated isolation better than −24.1 dB without any external decoupling measures and an envelope correlation coefficient (ECC) lower than 0.008. A four-antenna MIMO array is fabricated and measured to verify the feasibility. Across the operation band, the measured isolation of the antenna pair is better than −20.1 dB and other isolation levels are all better than −12.7 dB, the ECCs of any two antennas are lower than 0.13, and the total efficiency range of the four antennas is 35.2%~64.7%. The proposed dual antenna pair exhibits a great potential to be applied in future 5G MIMO smartphone.
Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer.

PURPOSE We conducted a phase II study of combination of the anti-insulin-like growth factor 1 receptor antibody CP-751,871 with paclitaxel and carboplatin (PCI) in advanced treatment-naïve non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS Patients were randomly assigned (2:1) to paclitaxel 200 mg/m(2), carboplatin (area under the plasma concentration-time curve of 6), and CP-751,871 10 to 20 mg/kg (PCI(10), PCI(20)) or paclitaxel and carboplatin alone (PC) every 3 weeks for up to six cycles. PCI(10-20) patients could continue CP-751,871 (figitumumab) treatment after chemotherapy discontinuation. Patients treated with PC experiencing disease progression were eligible to receive CP-751,871 at investigator's discretion. An additional nonrandomized single-arm cohort of 30 patients with nonadenocarcinoma tumor histology receiving PCI(20) was enrolled on completion of the randomized study. RESULTS A total of 156 patients were enrolled onto the randomized portion of the study. Safety and efficacy information are available for 151 patients (98 patients treated with PCI and 53 patients treated with PC). Forty-eight patients treated with PCI received PCI(10) and 50 patients received PCI(20) in two sequential stages. Twenty of 53 patients treated with PC received CP-751,871 after disease progression. PCI was well tolerated. Fifty-four percent of patients treated with PCI and 42% of patients treated with PC had objective responses. Sixteen of 23 patients assessable for efficacy in the nonrandomized single-arm extension cohort also responded to treatment. Of note, 14 of 18 randomly assigned and 11 of 14 nonrandomly assigned patients treated with PCI with squamous cell carcinoma histology had response to treatment, including nine objective responses in bulky disease. Responses were also observed in two patients with squamous histology receiving CP-751,871 on PC discontinuation. PCI(20)/PC hazard ratio for progression-free survival was 0.8 to 0.56, according to censorship. CONCLUSION These data suggest that PCI(20) is safe and effective in patients with NSCLC.
Histochemical evaluation of the lipid droplet content of bovine oviductal and endometrial epithelial cells.

Limited histochemical information is available concerning the lipid content of the bovine oviduct (Weeth & Herman, 1952; Bjorkman & Fredricsson, 1961) and endometrium (Weeth & Herman, 1952; Skjerven, 1956; Marinov & Lovell, 1968), and the proximity ofthe corpus luteum or developing follicle has not been examined as a possible local influence on such content. The object of this study was to examine the influence of the stage of the oestrous cycle as well as the proximity of the corpus luteum or developing follicle on the histochemically demonstrable lipid of the bovine oviduct and endometrium. Twenty Hereford and Angus heifers, 18-22 months of age, were observed twice daily for oestrus and only heifers exhibiting oestrous cycles of 18-22 days were used. The animals were killed at different stages of the oestrous cycle: oestrus = Day 1 ; metoestrus = Days 2-4; dioestrus = Days 5-18 ; pro-oestrus = Days 19-21. Tissue samples were obtained within 15 to 30 min of death and in¬ cluded the right and left ampullae (2 cm from the infundibulum), isthmi (1 cm from the uterotubal junction), and uterine horns (5 cm caudally from the uterotubal junction). The samples were placed on specimen holders and frozen in liquid nitrogen followed by cryostat sectioning at —15°C. Frozen sections, 10-15 µ thick, were attached to coverslips, stained with Oil Red O (Lillie, 1965), counter-stained with Harris's haematoxylin, mounted on slides and observed with bright-field microscopy. results demonstrate that distinct regional differences exist within the bovine oviduct with respect to cytoplasmic lipid content. There was no indication in this study that the lipid observed in the ampulla or isthmus was secreted into the lumen. The constant amount of lipid contained in the epithelial cells suggests that rather than being secreted for use by the embryo it may be utilized within the epithelial cells for metabolic needs. There is also the possibility that this material represents substances absorbed from the lumen.
Designed Ankyrin Repeat Proteins ( DARPins ) : Binding Proteins for Research , Diagnostics , and Therapy

Designed ankyrin repeat proteins (DARPins) can recognize targets with specificities and affinities that equal or surpass those of antibodies, but because of their robustness and extreme stability, they allow a multitude of more advanced formats and applications. This review highlights recent advances in DARPin design, illustrates their properties, and gives some examples of their use. In research, they have been established as intracellular, real-time sensors of protein conformations and as crystallization chaperones. For future therapies, DARPins have been developed by advanced, structure-based protein engineering to selectively induce apoptosis in tumors by uncoupling surface receptors from their signaling cascades. They have also been used successfully for retargeting viruses. In ongoing clinical trials, DARPins have shown good safety and efficacy in macular degeneration diseases. These developments all ultimately exploit the high stability, solubility, and aggregation resistance of these molecules, permitting a wide range of conjugates and fusions to be produced and purified. 489 A nn u. R ev . P ha rm ac ol . T ox ic ol . 2 01 5. 55 :4 89 -5 11 . D ow nl oa de d fr om w w w . a nn ua lr ev ie w s. or g A cc es s pr ov id ed b y U ni ve rs ity o f Z ur ic h H au pt bi bl io th ek o n 01 /0 8/ 15 . F or p er so na l u se o nl y. PA55CH26-Plueckthun ARI 1 December 2014 12:26
Dissipative stochastic sandpile model on small-world networks: Properties of nondissipative and dissipative avalanches.

A dissipative stochastic sandpile model is constructed and studied on small-world networks in one and two dimensions with different shortcut densities ϕ, where ϕ=0 represents regular lattice and ϕ=1 represents random network. The effect of dimension, network topology, and specific dissipation mode (bulk or boundary) on the the steady-state critical properties of nondissipative and dissipative avalanches along with all avalanches are analyzed. Though the distributions of all avalanches and nondissipative avalanches display stochastic scaling at ϕ=0 and mean-field scaling at ϕ=1, the dissipative avalanches display nontrivial critical properties at ϕ=0 and 1 in both one and two dimensions. In the small-world regime (2^{-12}≤ϕ≤0.1), the size distributions of different types of avalanches are found to exhibit more than one power-law scaling with different scaling exponents around a crossover toppling size s_{c}. Stochastic scaling is found to occur for ss_{c}. As different scaling forms are found to coexist in a single probability distribution, a coexistence scaling theory on small world network is developed and numerically verified.
Analysis of the performance of controlled semi-active knee joint with magnetorheological (MR) damper

Because of their short response time and ability to be controlled in real-time, use of MR dampers has been increased in the last decade in every area,. In prosthesis applications, it is important to maintain high levels of comfort and safety for the user. To achieve this objective stiffness of the damper utilized in prosthetics should be adjusted according to the gait phase and gait speed. In this study, to determine the necessary MR cylinder stiffness level, gait data of different users on different gait speeds were recorded. After determining the stiffness level of the prosthesis on different speeds, a Finite State Control algorithm was implemented for an above-knee proteshesis and the performance of this method was evaluated. Finally, performances of controlled and uncontrolled prostheses were compared to each other.
Full-Duplex Media-Based Modulation

Media-based modulation (MBM) is an attractive modulation scheme that offers MIMO benefits by placing digitally controlled parasitic elements as radio frequency (RF) mirrors near the transmit antenna. Different realizations of the ON/OFF status of these mirrors result in different channel fades which constitute the channel modulation alphabet. In this paper, we investigate full-duplex (FD) communication using MBM. First, we study full-duplex MBM (FD-MBM) scheme with full channel state information (CSI). Our numerical results show that,for the same spectral efficiency, FD-MBM outperforms FD with conventional modulation (FD-CM). Next, in order to relax the full CSI assumption, we investigate FD with differential MBM (FD-DMBM) with no CSI/partial CSI, where partial CSI refers to the availability of either self-interference CSI or desired-signal CSI. We propose detectors for the FD-DMBM with no CSI/partial CSI and illustrate their bit error performance.
Country Size and Country Momentum Effects in Emerging and Frontier Markets

We examine size and momentum effects based on country index returns for a universe of emerging and frontier market countries. We find that small countries outperform large countries by around 7% per year over the period 1990–2013. We find stronger evidence supporting country momentum when we use past-6-month as opposed to past- 12-month returns to define winner and loser countries. The momentum effects are also sensitive to the length of the holding period, with momentum effects stronger at shorter holding periods. We find that both size and momentum effects weaken over time.
Effect of iron deficiency on Trichuris suis and Ascaris suum infections in pigs

The objective of this experiment was to detect a possible interaction between iron deficiency and intestinal nematode infections. We report on a 2×2 study where thirty-one 10-week-old pigs fed a low or a normal iron diet were infected with both Trichuris suis (4500 eggs) and Ascaris suum (1200 eggs). No significant difference was detected between diet groups with respect to parasitological parameters for A. suum or the total number of adult T. suis recovered at necropsy 10 weeks p.i. However, in the low iron group T. suis were located more proximally and the worms were increased in length. A higher proportion of pigs with initial faecal egg excretion at 6 weeks p.i. was observed in the low iron group, indicating a shortened pre-patency period. Worm fecundity and total faecal egg excretion were also highest in the low iron group. A significant correlation was found between female worm length and fecundity. The peripheral eosinophil counts were diminished in the low iron host groups. The infected low iron group experienced more severe pathophysiological changes in terms of hypoalbuminaemia and decreases in erythrocyte volumes. A significant inverse correlation existed between iron content in the bone-marrow and liver (body) store. In conclusion, iron deficiency increased the severity of T. suis infection in pigs.
Effect of Hyaluronan Oligosaccharides on the Expression of Heat Shock Protein 72*

We have previously shown that intraarticular treatment with a hyaluronan (HA) preparation (840 kDa), HA84, up-regulates heat shock protein 72 (Hsp72) expression and suppresses degeneration of synovial cells in an arthritis model. In that study, the HA84 administered was degraded into HA oligosaccharides in the synovial tissue, suggesting that HA84 or degradation products of HA may up-regulate Hsp72 expression. Thus, in the present study, we examined the effects of HA of various molecular sizes on Hsp72 expression and cell death in stressed cells. Western blotting analysis showed that treatment of K562 cells with HA tetrasaccharides up-regulated Hsp72 expression after exposure to hyperthermia. On the other hand, treatment of the cells with HA of other sizes (di-, hexa-, deca-, dodecasaccharides), HA84, or tetrasaccharides of keratan sulfate did not elicit any change in expression of the Hsp72 protein. Treatment of the cells with tetrasaccharides of HA up-regulated not only expression of the Hsp72 protein but also Hsp72 mRNA expression and enhanced activation of HSF1, a transcription factor controlling Hsp72 expression, after exposure to hyperthermia. Because the level of Hsp72 protein was not affected by tetrasaccharides of HA when the K562 cells were kept at 37 °C without any stress, it is evident that tetrasaccharides of HA did not act as a stress factor. In addition, tetrasaccharides of HA suppressed cell death in the case of K562 cells exposed to hyperthermia and of PC12 cells under serum deprivation. These results suggest that a certain size of oligosaccharides,i.e. the tetrasaccharides of HA, up-regulates Hsp72 expression by enhancing the activation of HSF1 under stress conditions and suppresses cell death.
IS FRANCHISING THE ANSWER TO SMALL BUSINESS FAILURE RATE? AN EMPIRICAL STUDY

ABSTRACT This empirical research is an attempt to study differences in management practices and overall performance between franchised and non-franchised small firms. In all, 45 franchised firms and 50 non-franchised small firms operating in Montreal responded to a lengthy questionnaire. Results of the statistical analysis suggest that franchising may be the answer to small-business problems and failure rate. Franchise operators have better and wider management skills than non-franchised small-business owner/managers. This finding underscores the role of franchisor as a changing agent and training institution for budding entrepreneurs.
Arbeitsmarktspiegel: Entwicklungen nach Einführung des Mindestlohns (Ausgabe 1)

"On January 1, 2015 a statutory minimum wage was introduced in Germany. The Arbeitsmarktspiegel shows several important developments of the German labour market since its introduction. While overall employment in Germany continues to show a positive trend, the number of exclusively marginal part-time employees drops markedly at the turn of the year. This effect is strongest in industries and regions with a low average wage level. A little more than half of the decrease can be explained by persons changing directly into exclusively employment subject to social security. Yet, the data also show an increased amount of exits out of the labour market or at least out of the group of persons covered by the data. Transitions into unemployment play a rather secondary role in explaining the decline of marginal employment. The number of employees receiving additional benefits according to Social Code Book II slightly decreases after the introduction of the minimum wage. For this group, both the transitions into employment without benefit receipt as well as into exclusive benefit receipt are slightly increased. " (Author's abstract, IAB-Doku) ((en)) Additional Information Kurzfassung weitere Informationen: Datenanhang, Glossar, Bedienungsanleitung des Datentools
Delayed implantation in the spayed, progesterone treated adult mouse.

The influence of the time of spaying on the occurrence of delayed implantation has been intensively studied in the rat. Although it was originally reported that early spaying (Day 1 or 2 of pregnancy) followed by progesterone treatment did not lead to a delay in implantation, whereas spaying at a later stage (Day 4) did (Canivenc, Laffargue & Mayer, 1956; Cochrane & Meyer, 1957), further work on rats revealed that spaying before Day 4 generally resulted in delayed implantation (Psychoyos & Alloiteau, 1962; Nutting & Meyer, 1963; Mayer, 1963). Failure to observe delayed implantation more universally in the early experiments has been ascribed in part to incomplete ovariectomy. As the influence of the time of spaying on implantation has apparently not been examined in the adult mouse, the present work was undertaken. Endocrinolo-gical aspects of delayed implantation have been studied in the immature mouse (Smithberg & Runner, 1956, 1960) and in pregnant, lactating mice (Bloch, 1958). A total of fifty-seven adult female mice (TO strain) was used. After estab-lishing the pattern of the oestrous cycle over three cycles, the females were placed with fertile males on the day of pro-oestrus. The following morning they were examined for the presence of a copulation plug or of spermatozoa in the vaginal smear (Day 1 of pregnancy). Mated females were allocated at random to one of five groups and spayed on Day 1, 2, 3, 4 or 5 of pregnancy. Spaying took place between 10.00 and 13.00 hours. was given of determine whether implantation had occurred. When implantations were present the animals were killed; otherwise
Does a Dedicated Pediatric Team Within a Busy Mixed Emergency Department Make a Difference in Waiting Times, Satisfaction, and Care Transition?

Objectives: To evaluate the impact of a dedicated, free-floating, pediatric-targeted care delivery model on emergency department (ED) waiting times, parent satisfaction, and transition of care. Methods: A prospective, observational study was conducted between July 16 and August 12, 2007. It incorporated a before-and-after design with a 2-week preintervention and a 2-week intervention group. In the intervention period, the pediatric ED initiative (PEDI) team was introduced, which consisted of a free-floating doctor and nurse equipped to see pediatric patients. Consenting patients/parents were followed up by telephone 7 to 14 days after discharge regarding satisfaction and waiting times. Results: Four hundred fifty-three pediatric presentations (216 in the preintervention group and 237 in the intervention group) were analyzed, of which the PEDI team treated 81 pediatric patients during the intervention period. The intervention group had a significantly shorter length of stay in the ED (158 vs 194 minutes; P = 0.01). However, there was no difference in time to be seen by a doctor (80 vs 78 minutes; P = 0.54). Satisfaction of the total study group was significantly related to staff attitude and understanding of the wait. Conclusions: A dedicated pediatric team that specifically sees and treats pediatric populations during times of peak ED workload can reduce total ED length of stay for pediatric presentations, but has no effect on waiting time to see a doctor. There was only a marginal impact of the PEDI team on both transition of care and satisfaction indicators. Waiting times, staff attitude, and patient education proved to be important determinants of overall satisfaction for the total study group.
QUANTITATIVE GENETICS OF BRYOZOAN PHENOTYPIC EVOLUTION. I. RATE TESTS FOR RANDOM CHANGE VERSUS SELECTION IN DIFFERENTIATION OF LIVING SPECIES

The possible roles of random genetic change and natural selection in bryozoan speciation were analyzed using quantitative genetic methods on breeding data for traits of skeletal morphology in two closely related species of the cheilostome Stylopoma. The hypothesis that morphologic differences between the species are caused entirely by mutation and genetic drift could not be rejected for reasonable rates of mutation maintained for as few as 103 to 104 generations. Divergence times this short or shorter are consistent with the abrupt appearances of many invertebrate species in the fossil record, commonly followed by millions of years of morphologic stasis. To produce these differences over 103 generations or fewer, directional selection acting alone would require unrealistically high levels of minimum selective mortality throughout divergence. Thus, selection is unnecessary to explain the divergence of these species, except as a means of accelerating the effects of random genetic change on shorter time scales (directional selection), or decelerating them over longer ones (stabilizing selection). These results are consistent with a variety of models of phenotypic evolution involving random shifts between multiple adaptive peaks. Similar results were obtained by substituting trait heritabilities and genetic covariances reconstructed by partitioning within‐ and among‐colony phenotypic variance in place of the values based on breeding data. Quantitative genetic analysis of speciation in fossil bryozoan lineages is thus justified.