Miracle-dz/UniFAR-FTUs huggingface dataset:
Eselssätze und ihre Pferdefüße

L'interpretation des phrases donkey repose sur une analyse de plusieurs phenomenes : la semantique des SN definis et indefinis, la representation des anaphores discursives et du conditionnel, et l'interaction des SN indefinis et des pronoms anaphoriques avec le conditionnel. L'A. examine la maniere dont ces differents domaines sont traites par la theorie E-Type et par la theorie des representations discursives. Il propose ensuite une approche alternative basee sur le concept d'operation de selection, qui caracterise la selection d'un element parmi d'autres elements, et qui est represente formellement par l'operateur Epsilon. Cette approche permet de degager une structure plus fine des dependances entre SN indefinis
Modeling the Nonlinear Dynamics of Cellular Signal Transduction

During the past decades the components involved in cellular signal transduction from membrane receptors to gene activation in the nucleus have been studied in detail. Based on the qualitative biochemical knowledge, signalling pathways are drawn as static graphical schemes. However, the dynamics and control of information processing through signalling cascades is not understood. Here we show that based on time resolved measurements it is possible to quantitatively model the nonlinear dynamics of signal transduction. To select an appropriate model we performed parameter estimation by maximum likelihood and statistical testing. We apply this approach to the JAK-STAT signalling pathway that was believed to represent a feed-forward cascade. We show by comparison of different models that this hypothesis is insufficient to explain the experimental data and suggest a new model including a delayed feedback.
Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis.

BACKGROUND Systemic sclerosis (scleroderma) is characterized by immunologic abnormalities, injury of endothelial cells, and tissue fibrosis. Abnormal oxidative stress has been documented in scleroderma and linked to fibroblast activation. Since platelet-derived growth factor (PDGF) stimulates the production of reactive oxygen species (ROS) and since IgG from patients with scleroderma reacts with human fibroblasts, we tested the hypothesis that patients with scleroderma have serum autoantibodies that stimulate the PDGF receptor (PDGFR), activating collagen-gene expression. METHODS We analyzed serum from 46 patients with scleroderma and 75 controls, including patients with other autoimmune diseases, for stimulatory autoantibodies to PDGFR by measuring the production of ROS produced by the incubation of purified IgG with mouse-embryo fibroblasts carrying inactive copies of PDGFR alpha or beta chains or the same cells expressing PDGFR alpha or beta. Generation of ROS was assayed with and without specific PDGFR inhibitors. Antibodies were characterized by immunoprecipitation, immunoblotting, and absorption experiments. RESULTS Stimulatory antibodies to the PDGFR were found in all the patients with scleroderma. The antibodies recognized native PDGFR, inducing tyrosine phosphorylation and ROS accumulation. Autoantibody activity was abolished by preincubation with cells expressing the PDGFR alpha chain or with recombinant PDGFR or by PDGFR tyrosine kinase inhibitors. Stimulatory PDGFR antibodies selectively induced the Ha-Ras-ERK1/2 and ROS cascades and stimulated type I collagen-gene expression and myofibroblast phenotype conversion in normal human primary fibroblasts. CONCLUSIONS Stimulatory autoantibodies against PDGFR appear to be a specific hallmark of scleroderma. Their biologic activity on fibroblasts strongly suggests that they have a causal role in the pathogenesis of the disease.
Aggression in Low Functioning Children and Adolescents with Autistic Disorder

Background Parents, caregivers and mental health professionals have often reported violence and aggression in children or adolescents with autistic disorder. However, most of these observations derived from anecdotal reports, and studies on frequency and characterization of aggression in autism remain limited. Our objective was to better characterize and understand the different types of aggressive behaviors displayed by a large group of individuals with autism in different observational situations. Methodology/Findings The study was conducted on 74 children and adolescents with autism and 115 typically developing control individuals matched for sex, age and pubertal stage. Other-Injurious Behaviors (OIB) were assessed in three observational situations (parents at home, two caregivers at day-care, a nurse and a child psychiatrist during blood drawing) using validated scales. The frequency of OIB was significantly higher in individuals with autism compared to typically developing control individuals during the blood drawing (23% vs. 0%, P<0 .01). The parents observed significantly less OIB in their children than caregivers (34% vs. 58%, P<0.05). In addition, the most frequent concurrent behaviors occurring just before the appearance of OIB in individuals with autism were anxiety-related behaviors and excitation according to the parental as well as the caregiver observation. Conclusions/Significance The results suggest that in a stressful situation, such as the blood drawing, individuals with autism release their stress through behaviors such as OIB, whereas typically developing individuals regulate and express their stress through cognitive skills such as mental coping strategies, symbolization skills with representation and anticipation of the stressful situation, social interaction and verbal or non-verbal communication. The findings underline also the key role of the environment in assessing OIB and developing therapeutic perspectives, with an individual who modulates his/her behavior according to the environment, and an environment that perceives this behavior and reacts to it with different tolerance thresholds according to the observers.
Using Anchored Instruction to Teach About Assistive Technology

This investigation reports about the development and formative evaluation of an assistive technology instructional module that was developed in an integrated hypermedia format according to principles of anchored instruction. The module was field-tested with undergraduate students, graduate students, and professionals. Revisions were made in the module on the basis of feedback from the field tests. It was concluded that people respond positively to anchored instruction on the topic of assistive technology and that anchored instruction appears to have utility for both preservice and inservice training. A number of implications are described for those who are involved in the development and delivery of instruction about assistive technology.
Lexical knowledge and lexical retrieval in ageing: Insights from a tip-of-the-tongue (TOT) study

Elderly people experience more failures in word form access (tip-of-the-tongue events, ‘TOTs’) than young people. There is general agreement that TOTs are signs of cognitive decline in older people, but because of the diversity and ambiguity involved in measuring TOTs, certain questions regarding age-related trends in semantic access remain unsolved. Age-related increases in vocabulary may raise the level of efficiency of access to semantic representations and compensate for lexical access failures. We explore the relationships between lexical knowledge and lexical retrieval in ageing by re-examining the data obtained by Juncos-Rabadán et al. on TOTs induced in 140 volunteers aged from 19 to 82 years. We found that older adults displayed significantly more difficulty in accessing the phonological representations of personal names, but not those of common nouns. The results revealed greater semantic access efficiency in older participants. We discuss the findings in light of the transmission deficit theory of TOT production.
Mosaicing of Hyperspectral Images: The Application of a Spectrograph Imaging Device

Hyperspectral monitoring of large areas (more than 10 km2) can be achieved via the use of a system employing spectrometers and CMOS cameras. A robust and efficient algorithm for automatically combining multiple, overlapping images of a scene to form a single composition (i.e., for the estimation of the point-to-point mapping between views), which uses only the information contained within the images themselves is described here. The algorithm, together with the 2D fast Fourier transform, provides an estimate of the displacement between pairs of images by accounting for rotations and changes of scale. The resulting mosaic was successively georeferenced within the WGS-84 geographic coordinate system. This paper also addresses how this information can be transferred to a push broom type spectral imaging device to build the hyperspectral cube of the area prior to land classification. The performances of the algorithm were evaluated using sample images and image sequences acquired during a proximal sensing field campaign conducted in San Teodoro (Olbia-Tempio—Sardinia). The hyperspectral cube closely corresponds to the mosaic. Mapping allows for the identification of objects within the image and agrees well with ground-truth measurements.
A Cyclin-Dependent Kinase Inhibitor, Dinaciclib, Impairs Homologous Recombination and Sensitizes Multiple Myeloma Cells to PARP Inhibition

PARP1/2 are required for single-strand break repair, and their inhibition causes DNA replication fork collapse and double-strand break (DSB) formation. These DSBs are primarily repaired via homologous recombination (HR), a high-fidelity repair pathway. Should HR be deficient, DSBs may be repaired via error-prone nonhomologous end-joining mechanisms, or may persist, ultimately resulting in cell death. The combined disruption of PARP and HR activities thus produces synthetic lethality. Multiple myeloma cells are characterized by chromosomal instability and pervasive DNA damage, implicating aberrant DNA repair. Cyclin-dependent kinases (CDK), upstream modulators of HR, are dysregulated in multiple myeloma. Here, we show that a CDK inhibitor, dinaciclib, impairs HR repair and sensitizes multiple myeloma cells to the PARP1/2 inhibitor ABT-888. Dinaciclib abolishes ABT-888–induced BRCA1 and RAD51 foci and potentiates DNA damage, indicated by increased γH2AX foci. Dinaciclib treatment reduces expression of HR repair genes, including Rad51, and blocks BRCA1 phosphorylation, a modification required for HR repair, thus inhibiting HR repair of chromosome DSBs. Cotreatment with dinaciclib and ABT-888 in vitro resulted in synthetic lethality of multiple myeloma cells, but not normal CD19+ B cells, and slowed growth of multiple myeloma xenografts in SCID mice almost two-fold. These findings support combining dinaciclib with PARP inhibitors for multiple myeloma therapy. Mol Cancer Ther; 15(2); 241–50. ©2015 AACR.
Dangerous People, Dangerous Places: The Nature and Location of Young People's Victimisation and Fear.

Research focusing on the victimisation of young people outside the home has paid insufficient attention to less criminal forms of victimisation such as harassment and their relationship to fear expressed by children. Based on survey data of 2420 children aged 9-16 years from The Children and Young People's Safety Survey, this study focuses on the personal characteristics of offenders and victims, the types of victimisation experienced in specific locations, and the range of fears expressed by the children and young people. The study revealed a significant link between experiences of victimisation and higher levels of fear that appear to be gender-specific and bear a strong relationship to age. The results of the study have important theoretical and practical implications for preventing victimisation and reducing fears and anxieties.
EQUIVOCAL INFORMATION AND ATTRIBUTION: AN INVESTIGATION OF PATTERNS OF MANAGERIAL SENSEMAKING

Organizational research has revealed ample evidence of self-serving attributional patterns in managerial sensemaking, but has not yet resolved whether actor-observer attributional effects also influence managers' sensemaking tendencies. The primary purpose of this study was to investigate whether such actor-observer effects can be detected in managers' interpretation of equivocal information. Results indicate that managers receiving equivocal information about the performance of an organization described as their own credited positive outcomes to organizational strengths and blamed negative outcomes on environmental threats. In contrast, managers receiving equivocal information about an organization described as managed by others associated positive outcomes with environmental opportunities and linked negative outcomes to organizational weaknesses. Both self-serving and actor-observer attributional patterns were thus detected. 1997 by John Wiley & Sons, Ltd
Costs of Financial Distress: The German Evidence

In this paper we aim to verify the existence of costs of financial distress (cfd) for a sample of German CDAX firms using an ex-post approach originally due to Opler/Titman (1994). In contrast to this US-based study we do not find a significant interaction between high leverage and distress for German firms: firms in distressed industries with high ex ante leverage do not display lower sales growth than their ex-ante lower levered counterparts.
From the Genome to the Proteome: Uncovering Peptides in the Apis Brain

Neuropeptides, critical brain peptides that modulate animal behavior by affecting the activity of almost every neuronal circuit, are inherently difficult to predict directly from a nascent genome sequence because of extensive posttranslational processing. The combination of bioinformatics and proteomics allows unprecedented neuropeptide discovery from an unannotated genome. Within the Apis mellifera genome, we have inferred more than 200 neuropeptides and have confirmed the sequences of 100 peptides. This study lays the groundwork for future molecular studies of Apis neuropeptides with the identification of 36 genes, 33 of which were previously unreported.
Recent Trends in TANF Caseloads and the Status of TANF Recipients in West Virginia and Selected States Outside of Appalachia

Abstract The author examines the trends in TANF caseloads in West Virginia and selected states outside of Appalachia while including national trend data for further comparisons. State administrative data on the reasons for case closures is also reviewed. The major findings indicate that caseload declines accelerated in each state, as well as nationally, after the passage of PRWORA in 1996. National declines are resulting in an increasing concentration of Hispanics and minorities among TANF recipients. Administrative data indicates that one-third or fewer of the selected states' closures were attributed to employment. While states have improved their tracking systems, there is still some uncertainty surrounding the reasons for closures. This suggests the need for further research on data reporting.
Prolonging the postcomplex spike pause speeds eyeblink conditioning

Climbing fiber input to the cerebellum is believed to serve as a teaching signal during associative, cerebellum-dependent forms of motor learning. However, it is not understood how this neural pathway coordinates changes in cerebellar circuitry during learning. Here, we use pharmacological manipulations to prolong the postcomplex spike pause, a component of the climbing fiber signal in Purkinje neurons, and show that these manipulations enhance the rate of learning in classical eyelid conditioning. Our findings elucidate an unappreciated aspect of the climbing fiber teaching signal, and are consistent with a model in which convergent postcomplex spike pauses drive learning-related plasticity in the deep cerebellar nucleus. They also suggest a physiological mechanism that could modulate motor learning rates.
On the Variable Hierarchy of First-Order Spectra

The spectrum of a first-order logic sentence is the set of natural numbers that are cardinalities of its finite models. In this article, we study the hierarchy of first-order spectra based on the number of variables. It has been conjectured that it collapses to three variables. We show the opposite: it forms an infinite hierarchy. However, despite the fact that more variables can express more spectra, we show that to establish whether the class of first-order spectra is closed under complement, it is sufficient to consider sentences using only three variables and binary relations.
Peak Plantar Shear and Pressure and Foot Ulcer Locations: A Call to Revisit Ulceration Pathomechanics

The sensitivity and specificity of plantar pressure in identifying diabetic foot ulcers (DFUs) are relatively low, leading investigators to label peak pressure (PP) as a “poor” predictor (1). Moreover, pressure-reducing therapeutic footwear is only “meagerly” effective in preventing recurrent ulceration (2). These findings indicate that DFUs have a more complicated pathology. The purpose of this study was to investigate the clinical significance of plantar shear as it relates to ulcer locations using a custom-built stress plate (3). Eight volunteers, each with one recently healed forefoot plantar DFU, walked at self-selected speeds across the custom-built plate, quantifying both PP and peak shear (PS). In five subjects (63%), PP and PS occurred at different plantar sites. Of eight ulcers, five did not develop at PP locations (Fig. 1). Two ulcers developed at PP-only locations, whereas three developed at PS-only sites. One ulcer location matched overlapping locations of PP and PS. Surprisingly, two ulcers …
Statistical Patterns in Movie Rating Behavior

Currently, users and consumers can review and rate products through online services, which provide huge databases that can be used to explore people’s preferences and unveil behavioral patterns. In this work, we investigate patterns in movie ratings, considering IMDb (the Internet Movie Database), a highly visited site worldwide, as a source. We find that the distribution of votes presents scale-free behavior over several orders of magnitude, with an exponent very close to 3/2, with exponential cutoff. It is remarkable that this pattern emerges independently of movie attributes such as average rating, age and genre, with the exception of a few genres and of high-budget films. These results point to a very general underlying mechanism for the propagation of adoption across potential audiences that is independent of the intrinsic features of a movie and that can be understood through a simple spreading model with mean-field avalanche dynamics.
Prevalence and relationship of religiosity level and suicidal ideation in depressed patients

Objective The aim of this study was to determination the prevalence and relationship of religiosity level and suicidal ideation in depressed patients. Patients The sample included 100 patients recruited from psychiatric outpatient clinics of Zagazig University Hospitals. The patients included fulfilled the Diagnostic and statistical manual of mental disorders, 4th ed., text revision, criteria for depression, were between 18 and 60 years of age, of both sexes, and were from all socioeconomic and educational classes. Patients and methods All participants were subjected to a psychiatric assessment for depressive symptoms using the Arabic version of Beck Depression Scale, suicidal ideation using the Arabic version of the Beck Suicide Ideation Scale, and religiosity using the Scale of Islamic Religiosity Attitude. Results The results of the current study showed that the prevalence of suicidal ideations was 18 and 10% in those with low religiosity level among depressed patients. There was a statistically significant difference between religiosity and suicide in depressed patients. Conclusion The current study concluded that suicidal ideations are a highly prevalent phenomenon, and suicidal ideation was more prevalent in less religious patients than highly religious patients.
Selective serotonin reuptake inhibitor treatment for generalized anxiety disorder: a double-blind, prospective comparison between paroxetine and sertraline.

OBJECTIVE Selective serotonin reuptake inhibitors (SSRIs) appear to be an effective class of medications for the treatment of generalized anxiety disorder. Within the SSRI class, however, there have been no comparative treatment studies for this disorder. Therefore, in the present study, we compared the efficacy and tolerability of 2 SSRIs, paroxetine and sertraline, in the treatment of generalized anxiety disorder. METHOD In this parallel-group, double-blind, flexible-dose study, 55 patients with primary generalized anxiety disorder (DSM-IV criteria) were randomly assigned to receive either paroxetine or sertraline treatment for 8 weeks. Primary efficacy measures were the mean changes in Hamilton Rating Scale for Anxiety (HAM-A) scores as well as responder and remission rates based on the Clinical Global Impressions scale. Secondary efficacy measures consisted of the Indiana University Generalized Anxiety Measurement Scale and self-report ratings of anxiety, and quality-of-life outcome. Tolerability was assessed using the Systematic Assessment for Treatment Emergent Events questionnaire for treatment-emergent symptoms. RESULTS The intent-to-treat sample consisted of 53 patients who received medication for at least 1 week. Of the 53 patients, 43 completed the entire 8 weeks of treatment. Both paroxetine and sertraline resulted in significant decreases in mean HAM-A scores (paroxetine = 57% +/- 28%; sertraline = 56% +/- 28%). There were no differences between medication groups on response or remission rates, and tolerability was comparable. CONCLUSIONS Both paroxetine and sertraline appear similarly effective and well tolerated for the treatment of generalized anxiety disorder.
Fluoride increases tyrosine kinase activity in osteoblast‐like cells: Regulatory role for the stimulation of cell proliferation and Pi transport across the plasma membrane

Fluoride is one of the most effective agents for the treatment of vertebral osteoporosis because of its ability to increase osteoblast proliferation. The present study further investigates the role of protein tyrosine phosphorylation previously suggested to mediate the mitogenic effect of fluoride on bone‐forming cells. The activity of the plasma membrane Na‐coupled Pi transport system was monitored to assess the relationship between alterations in tyrosine phosphorylation and osteoblast activity induced by fluoride. The results indicate that vanadate, a selective inhibitor of tyrosine phosphatase, mimicked the stimulatory effect of fluoride on Pi transport. The change in Pi transport induced by fluoride was dose dependently inhibited by genistein, a potent inhibitor of tyrosine kinase. Genistein also inhibited the change in cell proliferation induced by fluoride. Associated with these observations, tyrosine phosphorylation activity was significantly increased in subcellular fractions isolated from UMR‐106 cells treated with fluoride as compared with those isolated from vehicle‐treated cells. This change in tyrosine phosphorylation activity was markedly blunted when genistein was added to the kinase assay buffer. It was not associated with any alteration in specific tyrosine phosphatase activity. There was also no evidence of a direct effect of fluoride on tyrosine phosphatase activity in isolated plasma membrane of UMR‐106 cells. In conclusion, the results of the present study suggest that fluoride enhances protein tyrosine phosphorylation in osteoblast‐like cells by enhancing tyrosine kinase activity. The results further support the hypothesis that this signal transduction mechanism is involved in the osteogenic effects of fluoride.