Miracle-dz/UniFAR-FTUs huggingface dataset:
Changing irreversible networks : Institutionalisation and infrastructure 1

Tasks-in-interaction: paper and screen based communication in collaborative activity. Latour, B. Social theory and the study of computerized work sites. Information technology and changes in organiza-6/4/97 12 ins (1996) objectification strategies. These strategies may be seen as constituting different networks, each of them being connected to the networks constituted by the different practices through gateways translating the relevant information according to the needs of the " objectifica-tion networks. " 5.4 Polyvalent networks There are limits, however, to the degree of incompatibility a gateway may overcome. Such limits do not exist for a different strategy which involves a kind of " multiple attachments. " This implies that an element is given polyvalent qualities and may attach to two (or more) different networks at the same time. To enable a complete transition from an old to a new network, first, all nodes must be attached to both networks, second, when all nodes are attached to the new, they may all detach from the old. The situation at the Children/ Heart ward at the National Hospital described in section 3.2 earlier illustrates this strategy. Here the staff operated three distinct, but partly overlapping, patient record schemes. The use of each of these patient record schemes corresponds to a different network thereby resulting in three superimposed networks. The staff move fluently and constantly across these networks in the course of their everyday work. They engage polyvalently in any of the three networks in turn as they themselves perform whatever translation that is required to make sense of this criss-crossing. Another example from the health care sector is the situation, at least in Norway, where it is not allowed to link local computer networks transferring patient information to Internet for security reasons. For this reason they have built a separate network of computers linked to Internet. Several employees access at least two computers, one linked to the internal network transferring patient information, using this network for communication within the hospital and another computer linked to Internet for communication with outside persons. The use of Internet is extending as knowledge about security is improved and security technologies is installed. It is expected that this process wil continue until all communication enabled by Internet will move to that network. So far this discussion has focused on the change of single, aligned networks. This is so because we see this as the major challenge. However, change at a …
Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6Chi and Ly6Clo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice

Background— Monocytes are critical mediators of atherogenesis. Deletion of individual chemokines or chemokine receptors leads to significant but only partial inhibition of lesion development, whereas deficiency in other signals such as CXCL16 or CCR1 accelerates atherosclerosis. Evidence that particular chemokine pathways may cooperate to promote monocyte accumulation into inflamed tissues, particularly atherosclerotic arteries, is still lacking. Methods and Results— Here, we show that chemokine-mediated signals critically determine the frequency of monocytes in the blood and bone marrow under both noninflammatory and atherosclerotic conditions. Particularly, CCL2-, CX3CR1-, and CCR5-dependent signals differentially alter CD11b+ Ly6G− 7/4hi (also known as Ly6Chi) and CD11b+ Ly6G− 7/4lo (Ly6Clo) monocytosis. Combined inhibition of CCL2, CX3CR1, and CCR5 in hypercholesterolemic, atherosclerosis-susceptible apolipoprotein E–deficient mice leads to abrogation of bone marrow monocytosis and to additive reduction in circulating monocytes despite persistent hypercholesterolemia. These effects are associated with a marked and additive 90% reduction in atherosclerosis. Interestingly, lesion size highly correlates with the number of circulating monocytes, particularly the CD11b+ Ly6G− 7/4lo subset. Conclusions— CCL2, CX3CR1, and CCR5 play independent and additive roles in atherogenesis. Signals mediated through these pathways critically determine the frequency of circulating monocyte subsets and thereby account for almost all macrophage accumulation into atherosclerotic arteries.
Estimating the parameters of gravitational waves from neutron stars using an adaptive MCMC method

We present a Bayesian Markov chain Monte Carlo technique for estimating the astrophysical parameters of gravitational radiation signals from a neutron star in laser interferometer data. This computational algorithm can estimate up to six unknown parameters of the target, including the rotation frequency and frequency derivative, using reparametrization, delayed rejection and simulated annealing. We highlight how a simple extension of the method, distributed over multiple computer processors, will allow for a search over a narrow frequency band. The ultimate goal of this research is to search for sources at known locations, but uncertain spin parameters; an example would be SN1987A.
News Framing as a Multiparadigmatic Research Program: A Response to Entman

A large and growing body of mass media research centers on the concept of “framing. ” This article responds to Entman's (1993) call for the establishment of a paradigm of news framing research, drawing on work in the sociology of knowledge to argue that news framing research operates according to principles of a Lakatosian research program (Lakatos, 1974) in which researchers employ and refine specific theories to generate findings in particular studies about a common core of irrefutable conjectures. In the metatheory developed here, the research program is inclusive of 3 paradigmatic outlooks, called cognitive, constructionist, and critical, that provide researchers with specific images with which to examine the interaction of media frames and individual- or social-level reality. Thus, contra Entman (1993), I argue that there is not, nor should there be, a single “mended” paradigm of framing research. The research program has benefited the communication discipline by encouraging researchers to use specific theories to progressively explicate a complex process.
Intrafamilial variability of the triphalangeal thumb phenotype in a Dutch population: Evidence for phenotypic progression over generations?

Triphalangeal thumbs (TPTs) are regularly caused by mutations in the ZRS in LMBR1. Phenotypic variability can be present in TPT‐families. However, recent observations suggest an increased occurrence of severe phenotypes in the Dutch TPT‐population. Therefore, the aim of this study is to investigate the progression of the clinical severity of TPT‐phenotype through generations. Index patients from a Dutch TPT‐population were identified. A 105C>G mutation in the ZRS has previously been confirmed in this population. Questionnaires regarding family occurrence and phenotypes were distributed. Subsequently, families were visited to validate the phenotype. Both occurrence and inheritance patterns of the TPT‐phenotype were analyzed through multiple generations. One hundred seventy patients with TPT were identified from 11 families. When considering all 132 segregations (parent‐to‐child transmission), 54% of the segregations produced a stable phenotype, 38% produced a more severe phenotype while only 8% of the phenotype was less severe when compared to the affected parents. Overall, 71% of the index patients had a more severe phenotype compared to their great‐grandparent. Although all family members share an identical mutation in the ZRS (105C>G), it does not explain the wide phenotypic range of anomalies. Our observational study provides better estimations for counseling and provides new insights in the long‐range regulation of SHH by the ZRS‐enhancer. In the current study, we provide evidence that the assumed variability in TPT‐phenotype is not random, but in fact it is more likely that the expression becomes more severe in the next generation. Therefore, we observe a pattern that resembles phenotypic anticipation in TPT‐families.
Can anomalous signal of sulfur become a tool for solving protein crystal structures?

A general method for solving the phase problem from native crystals of macromolecules has long eluded structural biology. For well diffracting crystals this goal can now be achieved, as is shown here, thanks to modern data collection techniques and new statistical phasing algorithms. Using solely a native crystal of tetragonal hen egg-white lysozyme, a protein of 14 kDa molecular mass, it was possible to detect the positions of the ten sulfur and seven chlorine atoms from their anomalous signal, and proceed from there to obtain an electron-density map of very high quality.
Men’s experience of a guided self-help intervention for hot flushes associated with prostate cancer treatment

Abstract Up to 80% of men who receive androgen deprivation therapy report hot flushes and for many these are associated with reduced quality of life. However it is recognised that there are a number of barriers to men’s engagement with support to manage symptoms and improve quality of life. This qualitative study was embedded within a larger randomised controlled trial (MANCAN) of a guided self-help cognitive behavioural intervention to manage hot flushes resulting among men receiving androgen deprivation therapy. The study aimed to explore the engagement and experiences with the guided self-help intervention. Twenty men recruited from the treatment arm of the MANCAN trial participated in a semi-structured interview exploring acceptability of the intervention, factors affecting engagement and perceived usefulness of the intervention. Interviews were audio-recorded, transcribed verbatim and analysed using a Framework approach. Over two thirds of respondents (69%) reported reading the intervention booklet in full and over 90% reporting practising the relaxation CD at least once a week. Analysis of the interviews identified three super-ordinate themes and these related to changes in hot flush symptomatology (learned to cope with hot flushes in new ways), the skills that participants had derived from the intervention (promoting relaxation and reducing stressors), and to a broader usefulness of the intervention (broader impact of the intervention and skills). The present study identified positive engagement with a guided self-help intervention and that men applied the skills developed through the intervention to help them undertake general lifestyle changes. Psycho-educational interventions (e.g. cognitive behaviour therapy, relaxation, and positive lifestyle elements) offer the potential to be both effective and well received by male cancer survivors.
The Ideal Man: An Investigation into Qualities That Influences Mate Selection among Female Undergraduate Students

In some traditional cultures, arranged marriages are common and courtship practices are severely restricted, with increased globalization and modernization, some of these traditional cultures are gradually changing. One wonders what influences choices of young ladies these days, using primary sources of data on a sample of 483 female students drawn through simple random sampling procedures. The study demonstrates that in spite of modernization, the choice of a life partner are guided by religion, social status ,security , love among other qualities . That increasingly the female gender are beginning to exercise their freedom to choose or select those they want to spend their life with, sometime in apparent disobedience to their parents.
A comprehensive evaluation of lexical reading in Italian developmental dyslexics

Italian developmental dyslexic readers show a striking length effect and have been hypothesised to rely mostly on nonlexical reading. Our experiments tested this hypothesis by assessing whether or not the deficit underlying dyslexia is specific to lexical reading. The effects of lexicality, word frequency and length were investigated in the same group of children in four separate experiments. Although dyslexics were slower and less accurate than skilled readers and had large length effects, they showed lexicality and word frequency effects in both reading aloud and lexical decision. In a cross-experiment comparison, we show that a single global factor explains a large proportion of the difference in reading performance between dyslexic and skilled readers. This factor may indicate a deficit at a prelexical level of analysis. Lexical activation seemed spared in the dyslexic children based on the effects of lexicality and frequency. These findings contrast the hypothesis that Italian dyslexics primarily engage in nonlexical reading.
Enhancement of Oxygen Reduction and Mitigation of Ionomer Dry-Out Using Insoluble Heteropoly Acids in Intermediate Temperature Polymer-Electrolyte Membrane Fuel Cells

The use of Cs 0.5 H 0.5 PW 12 O 40 insoluble salt as a superacid promoter in the catalyst layer of a polymer electrolyte membrane fuel cell (PEMFC) has been investigated. An increase of performance has been recorded at intermediate temperatures (110–130 °C) and under low relative humidity (R.H.). The promoter appears to mitigate the ionomer dry-out effects in the catalytic layer and produces an increase of the extent of the catalyst-electrolyte interface as demonstrated by cyclic voltammetry analysis. These effects are also corroborated by a significant decrease of polarization resistance at intermediate temperatures. Such characteristics have been demonstrated for a conventional membrane-electrode assembly based on a Pt-Co alloy and a Nafion 115 membrane.
Scalable and energy-efficient optical tree-based greedy router

The IP prefix lookup as a core function of today's Internet routers is becoming a bottleneck due to ever increasing throughput demands. The increase in the size of the routing tables limits the scalability of current routing architecture. Greedy routing as an alternative to IP routing does not require lookups in order to find the next hop, and neither requires storing a forwarding table in every node. In this routing, network nodes are assigned `coordinates' and the incoming packets are forwarded to the neighbours which are closer to the packets destinations. In this paper, a novel all-optical greedy router has been designed. In order to perform the greedy routing, each node is assigned an ID which determines the location of the node in the spanning tree of the network. The router is constructed through the interconnection of SOAs and directional couplers. The circuit provides high data rate and is more scalable and more energy-efficient than conventional IP routers.
Hardware, Software, Peopleware, Subjectivity

Summary Objective: This paper develops the closing address the author was asked to deliver at the MEDINFO 2004 Congress in San Francisco. Method: Starting from three working conferences, dealing with evaluation of health information systems, where he was involved, the author describes the evolution of his personal ideas. Results and Conclusions: First he proposes the main distinction between systems where the user(s) remain(s) external from the running program, from the ones where the user(s) interacting with the program become(s) the main component of the system. In the first case, the methods of evaluation are the conventional methods used in Medical Technology Assessment. In the second case, the whole knowledge in anthropology (considered in its broadest meaning), may contribute strongly to evaluation. It becomes clear that the subjectivity of the user(s), how he (or they) react(s) with the computing machinery, is a main key to the success or failure of the whole system. As the eradication of subjectivity is often considered, since the beginning of “modern times”, as a condition for progress, the author claims that such a temptation is deleterious for our civilization threatened by a comeback of barbarity, and is scientifically wrong. For that demonstration, he calls on both philosophical concepts (from Aristotle to E. Husserl, M. Henry and J. Searle), and the most recent advances of neurosciences.
Identification and characterization of a novel cytoskeleton-associated pp60src substrate

Transformation of cells by the src oncogene results in elevated tyrosine phosphorylation of two related proteins, p80 and p85 (p80/85). Immunostaining with specific monoclonal antibodies revealed a striking change of subcellular localization of p80/85 in src-transformed cells. p80/85 colocalizes with F-actin in peripheral extensions of normal cells and rosettes (podosomes) of src-transformed cells. Sequence analysis of cDNA clones encoding p80/85 revealed an amino-terminal domain composed of six copies of a direct tandem repeat, each repeat containing 37 amino acids, a carboxyl-terminal SH3 domain, and an interdomain region composed of a highly charged acidic region and a region rich in proline, serine, and threonine. The multidomain structure of p80/85 and its colocalization with F-actin in normal and src-transformed cells suggest that these proteins may associate with components of the cytoskeleton and contribute to organization of cell structure.
A Complementary Ordering Method for Class Imbalanced Problem

We propose a method called asymmetric bagging with vector complementary ordering (ABVCO) to handle the class unbalanced problem. The proposed approach is not dependent on artificially generated data or re-weighted data. It can avoid the synthesis of classifiers that favor the majority class. The method is applied to multi-modal biometric authentication for further raising the fusion classifier performances
EOG and EMG based virtual keyboard: A brain-computer interface

This paper discusses a brain-computer interface through electrooculogram (EOG) and electromyogram (EMG) signals. In situations of disease or trauma, there may be inability to communicate with others through means such as speech or typing. Eye movement tends to be one of the last remaining active muscle capabilities for people with neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig's disease. Thus, there is a need for eye movement based systems to enable communication. To meet this need, we proposed a system to accept eye-gaze controlled navigation of a particular letter and EMG based click to enter the letter. Eye -gaze direction (angle) is obtained from EOG signals and EMG signal is recorded from eyebrow muscle activity. A virtual screen keyboard may be used to examine the usability of the proposed system.
Source Forager: A Search Engine for Similar Source Code

Developers spend a significant amount of time searching for code: e.g., to understand how to complete, correct, or adapt their own code for a new context. Unfortunately, the state of the art in code search has not evolved much beyond text search over tokenized source. Code has much richer structure and semantics than normal text, and this property can be exploited to specialize the code-search process for better querying, searching, and ranking of code-search results. We present a new code-search engine named Source Forager. Given a query in the form of a C/C++ function, Source Forager searches a pre-populated code database for similar C/C++ functions. Source Forager preprocesses the database to extract a variety of simple code features that capture different aspects of code. A search returns the $k$ functions in the database that are most similar to the query, based on the various extracted code features. We tested the usefulness of Source Forager using a variety of code-search queries from two domains. Our experiments show that the ranked results returned by Source Forager are accurate, and that query-relevant functions can be reliably retrieved even when searching through a large code database that contains very few query-relevant functions. We believe that Source Forager is a first step towards much-needed tools that provide a better code-search experience.
On User Pairing in NOMA Uplink

User pairing in Non-Orthogonal Multiple-Access (NOMA) uplink based on channel state information is investigated considering some predefined power allocation schemes. The base station divides the set of users into disjunct pairs and assigns the available resources to these pairs. The combinatorial problem of user pairing to achieve the maximum sum rate is analyzed in the large system limit for various scenarios, and some optimum and sub-optimum algorithms with a polynomial-time complexity are proposed. In the first scenario, $2M$ users and the base station have a single-antenna and communicate over $M$ subcarriers. The performance of optimum pairing is derived for $M\rightarrow \infty$ and shown to be superior to random pairing and orthogonal multiple access techniques. In the second setting, a novel NOMA scheme for a multi-antenna base station and single carrier communication is proposed. In this case, the users need not be aware of the pairing strategy. Furthermore, the proposed NOMA scheme is generalized to multi-antenna users. It is shown that random and optimum user pairing perform similarly in the large system limit, but optimum pairing is significantly better in finite dimensions. It is shown that the proposed NOMA scheme outperforms a previously proposed NOMA scheme with signal alignment.
Intracranial angioplasty & stenting for cerebral atherosclerosis: a position statement of the American Society of Interventional and Therapeutic Neuroradiology, Society of Interventional Radiology, and the American Society of Neuroradiology.

STROKE is the third leading cause of death and the leading cause of adult disability in North America, Europe, and Asia (1,2). Intracranial cerebral atherosclerosis accounts for approximately 8 to 10% of all ischemic strokes with a higher reported incidence in the Asian, African, and Hispanic descent populations (3–5). Risk factors include insulin-dependent diabetes mellitus, hypercholesterolemia, hypertension, and cigarette smoking (6–8). In the United States, it is estimated that 40,000 to 60,000 new strokes per year are due to intracranial cerebral atherosclerosis.
The reflective peephole method: Ruralism and awkwardness in the ethnography of rural China

Starting with Arthur Smith’s metaphor of the ‘peephole method’, this article explores the issues of ruralism and awkwardness which underlie much ethnographic fieldwork in rural China. In the first part, the continuing influence of ruralism—the idea that the Chinese countryside represents the ‘real’ China—is discussed. This idea is based on a radical conceptual separation of the countryside and the city, which denies modern everydayness to the countryside. If we accept that the modern everyday is now present in rural China and that ordinary people are aware of ruralism and its opposites (urbanism and modernity), we need to find research methods suitable to address the entanglement and the social uses of ruralist and modernist representations in everyday life. In the second part of the article, I argue that the ‘reflective peephole method’ could be such a method. Starting from the awkwardness I felt in my own fieldwork in south-western Hubei Province, I argue that the dilemmas of the ‘peephole method’ might be a good starting point for reflecting on the intensified ambiguity of moral discourse and action in contemporary rural China.
CONSISE statement on the reporting of Seroepidemiologic Studies for influenza (ROSES‐I statement): an extension of the STROBE statement

Population‐based serologic studies are a vital tool for understanding the epidemiology of influenza and other respiratory viruses, including the early assessment of the transmissibility and severity of the 2009 influenza pandemic, and Middle East respiratory syndrome coronavirus. However, interpretation of the results of serologic studies has been hampered by the diversity of approaches and the lack of standardized methods and reporting.