Miracle-dz/UniFAR-FTUs huggingface dataset:
Relational Web Search

Facts are naturally organized in terms of entities, classes, and their relationships as in an entity-relationship diagram or a semantic network. Search engines have eschewed such structures because, in the past, their creation and processing have not been practical at Web scale. This paper introduces the extraction graph, a textual approximation to an entity-relationship graph, which is automatically extracted from Web pages. The extraction graph is an intermediate representation that is more informative than a mere page-hyperlink graph but far easier to construct than a semantic network. The paper also introduces TextRunner, a search engine that utilizes this representation to answer complex relational queries that are dicult to answer using today’s search engines or Web Information Extraction (IE) systems. The paper compares TextRunner to a state-of-the-art IE system on list searches, and nds that TextRunner is 40% more precise, with 11% better recall than the IE system. Our experiments, computed over a 90-million page corpus and a 227-million node extraction graph, show how TextRunner will scale to billions of pages.
Nonlinear Statistical Process Monitoring based on Competitive Principal Component Analysis

Traditional process monitoring techniques assume the normal operating conditions (NOC) to be distributed normally. However, for processes with more than one operating regime, building a single subspace model to monitor the whole process operation performance may not be efficient and will lead to high rate of missing alarm. To handle this situation, a monitoring strategy using multiple subspace models is presented in this paper. From the experimental results using a simulation model of a continuous flow aerated bioreactor for wastewater treatment in pulp and paper industry it has been shown that the proposed approach is very promising.
A fully integrated Class-E power amplifier in 0.13um CMOS technology

This paper presents a fully integrated differential Class-E power amplifier implemented in 130 nm CMOS process. The series resonant circuit and the reactance provided by inductor for Class-E operation is provided by a single parallel resonant circuit and a capacitor respectively. Driving stage and the output balun is also present on-chip. From a 2.5 V supply and a load of 50 Ω, the output power is greater than 19.5 dBm and the overall PAE including driving stage remains above 43% for the entire band of 1.4 GHz to 1.8 GHz.
Effect of competitive adsorption on zinc removal from aqueous solution and zinc smelting effluent by eucalyptus leaf-based magnetic biosorbent

ABSTRACT The objectives of this study were to investigate the competitive sorption behaviors and mechanisms of heavy metals onto ELMB, a novel eucalyptus-leaf-based magnetic biosorbent, and to study the potential application of ELMB in the treatment of actual zinc smelting effluent after a necessary pretreatment process. ELMB and ELMB-metals systems were characterized using several techniques. Competitive sorption of Zn2+ with Pb2+, Cu2+ and Cd2+ onto ELMB was studied by batch experiments and the used sorbent was separated under a magnetic field. The results show that the ELMB can be considered as paramagnetic material with various functional groups on its surface. The presence of Pb2+, Cu2+ and Cd2+ significantly decreases the sorption of Zn2+ in either the binary system or multimetal systems. The order of adsorption preference is Pb2+ > Cu2+ > Cd2+ > Zn2+ in multimetal systems and the sequence of competitive ability to zinc is: Pb2+ > Cu2+ > Cd2+. Non-competitive Langmuir multicomponent isotherm model fits to the adsorption data of Pb2+ and Cu2+ well in aqueous solution. The co-existent Ca2+ and SO42− decrease the removal efficiencies of heavy metals while the presence of Na+ and Cl− shows little effect in the multimetal solution. In the case of actual zinc smelting effluent, “pretreatment + ELMB sorption” is successfully applied to remove heavy metals and the contents of Zn2+ and its associated metals are well below discharge limits.
Description Logic in Practice: A CLASSIC Application

Descr ipt ion logic-based configurat ion applications have been used w i t h i n A T & T since 1990 to process over two and a half b i l l ion dollars wor th of orders. Whi le this fami ly of applications[4] has widely acknowledged importance, it is di f f icul t to use for pedagogical purposes since the typical product configured is a highly interconnected, complicated technical piece of equipment like the DACS IV -2000 . 1 We have developed a smaller-scale configurat ion appl icat ion that has analogous reasoning processes but a more approachable domain—that of bui ld ing home theater systems. Th is appl icat ion provides a p la t form for expla in ing how Descr ipt ion Logic-based Systems (DLSs) work, in our case the C L A S S I C knowledge representation system[ l ] , and how they can support industr ia l applications like conf igurat ion.
Neurturin's Role in Sensory Neuron Plasticity

Primary sensory neurons are one of the major components of the peripheral nervous system and are required for collecting and transmitting information regarding the external and internal environment to the central nervous system (CNS). The cell bodies of these neurons are located in peripheral ganglia adjacent to the spinal cord and associated with cranial nerves V, VII, IX and X (cranial nerves I, II, VIII also carry sensory information but have specialized sensory organs that detect specific stimuli). Primary sensory neurons whose cells bodies are found in spinal ganglia (also called dorsal root ganglia (DRG)) have been the focus of intense scientific investigation because of their role in transmitting sensation including those associated with pain and as a model system for understanding mechanisms of development and plasticity. The studies presented in this dissertation focus on the interactions between primary sensory neurons and growth factors that regulate developmental events, as well as adult physiology. In particular, these studies examine sensory neurons that respond to the growth factor neurturin (NRTN), the majority of which innervate the epidermis.
Genetic dissection of attractant-induced conductances in Paramecium

SUMMARY Paramecium tetraurelia is attracted to acetate and biotin by swimming smoothly and fast up gradients of these attractants, and turning immediately and slowing down when leaving these stimuli. We use a group of mutants, each with a different defect in an identified ion conductance, to show that these two stimuli open different ion channels, and the behaviors that occur upon application of stimulus (on-response) and removal of stimulus (off-response) have different roles in attraction to these two stimuli. The most important parameters for successful attraction to acetate are the on-response behaviors of fast swimming with few turns, and the mutants' behavior suggests that IK(Ca,h) is the conductance involved that initiates this behavior. IK(Ca,h or d) appears to be important to the on-response in biotin; the results with mutants suggest that the biotin off-response depolarization is initiated by an ICa, which can be large enough or close enough to channels to open IK(Ca,d), INa(Ca) and IMg(Ca).
Utilizing Latent Semantic Analysis to Provide Automated Educational Support

The traditional in-class methodology was developed for small classrooms of 15-20 students. Low student to teacher ratios, typically under 20 students per teacher, have been preferred and recommended to maximize student achievement, engagement, and retention from research starting in the 1970's [1] [2] [3]. Actual classroom sizes for K-12 vary depending on a variety of factors [4]. Today, some undergraduate Engineering courses consist of more than ten times that many students: some who are interested, some who just want a passing grade, and others who are not yet ready for college and do not properly prepare to study material. In fact, according to a national survey consisting of 560 colleges and universities in 2016, 20% of first-year college students had difficulty learning and getting help with coursework [5] [6]. As classroom sizes increase and varying levels of experiences of students, this situation will only exacerbate existing problems and deficiencies utilizing current teaching methodologies and tools. An automated tool that can provide similar recommendations would free up all that time and allow for more meaningful discussions. Also, students would save hours individually in terms of getting stuck, waiting for responses, and then spending time to get back to where they were later when they got stuck. This is potentially even more beneficial for students who do not typically ask questions when they get stuck, hoping that attending lecture or discussion will answer their questions. Utilizing latent semantic analysis (LSA), a natural language processing algorithm, recommendations can be created through mathematical searching and categorizing sources using singular value decomposition (SVD). The automated tool can pre-emptively suggest additional reading and viewing material, allowing the student to continue their studies without a long wait interval.
[Evolution in the epidemiology of non-variceal upper digestive hemorrhage from 1985 to 2006].

OBJECTIVES to describe changes occurred in the characteristics of patients suffering from non-variceal upper gastrointestinal bleeding, and in this condition s epidemiology. METHODS a prospective study was carried out to examine the occurrence and causes of non-variceal upper digestive bleeding in the corresponding health department at Virgen de las Nieves Hospital in Granada, Spain. In this study three periods of time were compared. Group 1 (1985): 284 patients; group 2 (1996): 259 patients; and group 3 (2006) 291 patients. RESULTS in group 1 the incidence was 71/100,000 inhabitants; in group 2, 64/100,000; and in group 3, 66/100,000. Mean age in 1985 was 57.4; in 1996, 59.6; and in 2006, 62.38. In all groups a majority of cases were men (75.4, 69.5, and 72.2%, respectively). Major causes included duodenal ulcer (1: 40.5%; 2: 43.2%; 3: 40.5%), gastric ulcer (1: 24.3%; 2: 30%; 3: 18.9%); LAMG (1: 53.3%; 2: 43.2%; 3: 9.6%); neoplasia (1: 1.7%; 2: 1.9%; 3: 5.2%), and vascular injuries (1: 0.5%; 2: 1.5%; 3: 9.3%). The death rate was 2.5% in 1985; 1.5% in 1996; and 1% in 2006. CONCLUSIONS a significant increase in mean age over the years was detected. The most frequent cause of hemorrhage was duodenal ulcer followed by gastric ulcer. Of significance is an increase in the proportion of neoplasms above of vascular injuries in the later group as apposed to the earlier one. We found no significant difference in mortality between groups.
Modeling the Cost of Redistribution in Scheduling

Distributed heterogeneous resources coordinated by fast networks provide a new platform for resource-intensive parallel applications. However, careful scheduling of such applications is required to achieve their performance potential. Since resource load varies dynamically, the scheduling mechanism may consider redistribution of application tasks to improve performance. In this paper, we focus on the development of dynamically parametrizable models to determine the cost (in terms of execution delay) of redistribution. When such models are combined with predictive models for application execution, a scheduler can determine whether redistribution is pro table at a given point in time.
Extensive histological sampling following focal therapy of clinically significant prostate cancer with high-intensity focused ultrasound.

PURPOSE Clinically significant localized prostate cancer (PCa) is currently treated using whole-gland therapy. This approach is effective but is associated with genitourinary and rectal side-effects. Focal therapy of PC has been proposed as an alternative. The aim of the study was to determine the oncologic and functional outcomes of focal high-intensity focused ultrasound (HIFU) therapy for PCa. METHODS This was a single-centre prospective study in which 75 men were treated between 04/2014 and 04/2018. Multiparametric magnetic resonance imaging (mpMRI) and transperineal template saturation prostate biopsies (TTSPB) were performed to localise PCa, followed by focal ablation using HIFU. The primary endpoint was detection of clinically significant prostate cancer (Gleason score ≥7, csPCa) at the 6 months follow-up TTSPB. Of secondary interest were the genitourinary side effects. RESULTS The median age was 67 yrs (interquartile range [IQR] 60-71) and prostate-specific antigen (PSA) was 5.87 ng/ml (4.64-7.44). There were five (6.7%) low-risk and 70 (93.3%) intermediate-risk cancers. CsPCa was detected in 41% (95% CI: 30.3%- 53.0%) of men undergoing biopsy at 6 months with a median sampled core number of 44 (IQR 36-44). PSA (OR 1.17 [0.49-2.85], p=0.71) and mpMRI (sensitivity 14.3% [6.7-31.5%]) performed poorly in prediction of positive biopsies. Pad-free continence and erections sufficient for penetration were preserved in 63/64 (98.4%) and 31/45 (68.9%) patients, respectively. CONCLUSION Focal therapy using HIFU leads to a low rate of genitourinary side-effects. Follow-up biopsy of the treated and untreated prostate remains the only modality to adequately select men in need of early salvage treatment.
Complete Genome of Bacillus subtilis Myophage CampHawk

ABSTRACT The study of bacteriophages infecting the model organism Bacillus subtilis has provided an abundance of general knowledge and a platform for advances in biotechnology. Here, we announce the annotated genome of CampHawk, a B. subtilis phage. CampHawk was found to be an SPO1-like phage with similar gene content and arrangement.
EP3/FP dual receptor agonist ONO-9054 administered morning or evening to patients with open-angle glaucoma or ocular hypertension: results of a randomised crossover study

Background/aims The novel prostaglandin E (EP) 3 and prostaglandin F (FP) receptor agonist ONO-9054 is effective in lowering intraocular pressure (IOP) in patients with ocular hypertension and open-angle glaucoma when administered once daily. This study compares the effects of morning (AM) versus evening (PM) dosing of ONO-9054 on tolerability and IOP lowering. Methods This was a single-centre, randomised, double-masked, two-sequence, placebo-controlled crossover study in 12 subjects with bilateral primary open-angle glaucoma or ocular hypertension. Two 14-day crossover regimens were separated by a 2-week washout: ONO-9054 (1 drop to each eye) in the morning (07:00) and vehicle in the evening (19:00) and vice versa. IOP was measured multiple times during select days. Ocular examinations also evaluated safety and tolerability. Results Mild ocular hyperaemia, reported by six subjects with PM dosing, was the most frequent adverse event. Mild to moderate dryness was also slightly more frequent after PM dosing. Maximum IOP reduction from baseline occurred on day 2 with decreases from baseline of −7.4 mm Hg (−30.8%) for AM dosing and −9.1 mm Hg, (−38.0%) for PM dosing; after 14 days, mean reduction in IOP was −6.8 mm Hg (−28.6%) for AM dosing and −7.5 mm Hg (−31.0%) for PM dosing. Conclusions PM dosing of ONO-0954 was associated with a slightly increased frequency of mild hyperaemia and mild to moderate dryness. Both dosing schedules provided sustained reduction in IOP. Trial registration number NCT01670266.
Multimodal city-verification on flickr videos using acoustic and textual features

We have performed city-verification of videos based on the videos' audio and metadata, using videos from the MediaEval Placing Task's video set, which contain consumer-produced videos “from-the-wild”. 18 cities were used as targets, for which acoustic and language models were trained, and against which test videos were scored. We have obtained the first known results for the city verification task, with an EER minimum of 21.8%, suggesting that ~80% of test videos, when tested against a correct target city, were identified as belonging to that city. This result is well above-chance, even as the videos contained very few city-specific audio and metadata features. We have also demonstrated the complementarity of audio and metadata for this task.
Cortical Glutamic Acid Decarboxylase 67 Expression in Schizophrenia: Defining the Deficit

Cognitive impairments are a core feature of schizophrenia and the best predictor of functional outcome, though current pharmacotherapies offer only limited cognitive improvement. Cognitive deficits span multiple domains and thus may reflect an overarching alteration in cognitive control, the ability to adjust thoughts or behaviors to achieve goals. Cognitive control depends on the dorsolateral prefrontal cortex (DLPFC), which exhibits altered activity in schizophrenia. DLPFC dysfunction is thought to be due, at least partially, to alterations in interneurons, which are regulated by levels of the GABA synthesizing enzyme glutamic acid decarboxylase (GAD). A deficit in the 67 kDa isoform (GAD67), responsible for the majority of cortical GABA synthesis, has been widely replicated in the DLPFC of subjects with schizophrenia and is particularly prominent in the parvalbumin (PV)-containing subclass of interneurons. However, little is known about the relationship of DLPFC GAD67 mRNA levels and medication use, substance abuse, and illness severity and chronicity; translation of the transcript into protein; or protein levels in axon terminals, a key site of GABA production and function. Additionally, alterations in other GABA neurotransmission markers, including lower PV and GABA membrane transporter 1 (GAT1), are also present, and thought to result from lower GAD67 in PV neurons, though this hypothesis has not been directly tested. Accordingly, here we measured GAD67 mRNA, tissue-level protein, and axon terminal protein in PV cells, and examined whether lower PV and GAT1 mRNA are consequences of lower GAD67 protein in PV neurons. GAD67 mRNA levels were significantly 15% lower in schizophrenia subjects, but transcript levels were not associated with medication use, substance abuse, predictors or measures of disease severity, or illness chronicity. GAD67 protein levels were significantly 10% lower in total gray matter and 49% lower in PV axon terminals. These data provide an extensive characterization of the GAD67 deficit in schizophrenia, and provide novel evidence of a functional impairment in PV neurons that may underlie cognitive deficits. Additionally, PV and GAT1 mRNAs were not altered in two mouse models with lower GAD67 expression, suggesting that lower GAD67 is unlikely to be the cause of reduced PV and GAT1 mRNA in schizophrenia.
Hybrid HMM/MLP models for times series prediction

We present a hybrid model consisting of an hidden Markov chain and MLPs to model piecewise stationary series. We compare our results with the model of gating networks (A.S. Weigend et al. [6]) and we show than, at least on the classical laser time series, our model is more parcimonious and give better segmentation of the series.
Variation in activity rates of consultant surgeons and the influence of reward structures in the English NHS

Objectives: To explore variation in the National Health Service (NHS) activity rates of consultant surgeons, and examine whether activity is dependent upon the type of contract held and/or bonus payments, after accounting for age and other consultant and hospital characteristics. Methods: NHS Hospital Episode Statistics (HES) for England were used in combination with workforce data in five surgical specialties in 1998/99 and 1999/2000. Descriptive statistics were used to explore variation in activity rates. A multi-level model was used to analyse the relationship between NHS contract and bonus payments, and activity. Results: There is considerable variation in activity rates of English NHS consultant surgeons, with and without adjustment for casemix. Interquartile variation shows that the top 25% of consultants have activity rates 60 to 85% higher than the bottom 25%. A multi-level model indicates that consultant surgeons with a 'maximum part-time' contract have significantly higher activity rates than those with a full time contract (129 more finished consultant episodes (FCEs) per year, 95% CI 97-160). Consultant surgeons who hold discretionary salary points undertake significantly more activity than those without (95 FCEs, 95% CI 62-128). Those with a distinction award (a type of bonus payment) have a tendency towards higher activity rates, but this does not reach statistical significance (48 FCEs, 95% CI -4 to 103). Conclusions: 'Maximum part-time contract' status is associated with higher absolute activity rates among NHS surgeons. Rich data sources like HES merit careful exploration and increased use as an essential first step in measuring and managing variations in specialists' performance.
Measurement of Online Discussion Authenticity within Online Social Media

In this paper, we propose an approach for estimating the authenticity of online discussions based on the similarity of online social media (OSM) accounts participating in the online discussion to known abusers and legitimate accounts. Our method uses similarity functions for the analysis and classification of OSM accounts. The proposed methods are demonstrated using Twitter data collected for this study and a previously published Arabic Honeypot dataset. The data collected during this study includes manually labeled accounts and a ground truth collection of abusers from crowdturfing platforms. Demonstration of the discussion topic’s authenticity, derived from account similarity functions, shows that the suggested approach is effective for discriminating between topics that were strongly promoted by abusers and topics that attracted authentic public interest.
Inhibition of DYRK1A Stimulates Human β-Cell Proliferation

Restoring functional β-cell mass is an important therapeutic goal for both type 1 and type 2 diabetes (1). While proliferation of existing β-cells is the primary means of β-cell replacement in rodents (2), it is unclear whether a similar principle applies to humans, as human β-cells are remarkably resistant to stimulation of division (3,4). Here, we show that 5-iodotubercidin (5-IT), an annotated adenosine kinase inhibitor previously reported to increase proliferation in rodent and porcine islets (5), strongly and selectively increases human β-cell proliferation in vitro and in vivo. Remarkably, 5-IT also increased glucose-dependent insulin secretion after prolonged treatment. Kinome profiling revealed 5-IT to be a potent and selective inhibitor of the dual-specificity tyrosine phosphorylation–regulated kinase (DYRK) and cell division cycle–like kinase families. Induction of β-cell proliferation by either 5-IT or harmine, another natural product DYRK1A inhibitor, was suppressed by coincubation with the calcineurin inhibitor FK506, suggesting involvement of DYRK1A and nuclear factor of activated T cells signaling. Gene expression profiling in whole islets treated with 5-IT revealed induction of proliferation- and cell cycle–related genes, suggesting that true proliferation is induced by 5-IT. Furthermore, 5-IT promotes β-cell proliferation in human islets grafted under the kidney capsule of NOD-scid IL2Rgnull mice. These results point to inhibition of DYRK1A as a therapeutic strategy to increase human β-cell proliferation.