Miracle-dz/UniFAR-FTUs huggingface dataset:
SYSTEMATIC ANALYSES OF RADIOCARBON AGES OF COEXISTING PLANKTONIC FORAMINIFERA

ABSTRACT We compare radiocarbon (14C) ages of coexisting planktonic foraminifera species from sediment cores VM12-107 and KNR166-2-26JPC from the Equatorial Atlantic Ocean for three time periods (Holocene, Heinrich Stadial 1, last glacial maximum). We find a maximum inter-species difference of 1200 14C yr. On average, the 14C ages deviate by ∼300 yr between Globigerinoides ruber and other species. In most cases, this exceeds the analytical uncertainty range of the measurements and thus renders the choice of species for generating age models as important as sample weight. While modern stratified water-column profiles imply an increase in 14C ages with water depth, we observe an expected parallel increase of 14C ages and δ18O only at VM12-107. The mismatch between 14C ages and δ18O at KNR166-2-26JPC likely results from the effects of bioturbation and the hydrographic setting. The largest difference in 14C ages between mixed-layer versus thermocline-calcifying planktonic foraminifera are observed during Heinrich Stadial 1 despite a decrease in upper-ocean stratification at that time. This difference is likely the result of inconsistent increases in 14C reservoir ages during times of reduced overturning circulation masking the potential of 14C ages of coexisting planktonic foraminifera to reflect the density stratification of the water column.
Changes in gut microbiota composition after 12 weeks of a home-based lifestyle intervention in breast cancer survivors during the COVID-19 lockdown

Background Breast cancer (BC) is the second-leading cause of cancer-related death worldwide. This study aimed to investigate the effects of a 12-week home-based lifestyle intervention (based on nutrition and exercise) on gut microbial composition in twenty BC survivors of the MoviS clinical trial (protocol: NCT 04818359). Methods Gut microbiota analysis through 16S rRNA gene sequencing, anthropometrics, Mediterranean Diet (MD) adherence, and cardiometabolic parameters were evaluated before (Pre) and after (Post) the lifestyle intervention (LI). Results Beneficial effects of the LI were observed on MD adherence, and cardiometabolic parameters (pre vs post). A robust reduction of Proteobacteria was observed after LI, which is able to reshape the gut microbiota by modulating microorganisms capable of decreasing inflammation and others involved in improving the lipid and glycemic assets of the host. A significant negative correlation between fasting glucose and Clostridia_vadinBB60 (r = -0.62), insulin and homeostatic model assessment (HOMA) index and Butyricicoccus genera (r = -0.72 and -0.66, respectively), and HDL cholesterol and Escherichia/Shigella (r = -0.59) have been reported. Moreover, positive correlations were found between MD adherence and Lachnospiraceae_ND3007 (r = 0.50), Faecalibacterium (r = 0.38) and Butyricimonas (r = 0.39). Conclusion These data suggest that adopting a healthy lifestyle, may contribute to ameliorate several biological parameters that could be involved in the prevention of cancer relapses through the modulation of gut microbiota.
General Practitioners’ Own Traumatic Experiences and Their Skills in Addressing Patients’ Past History of Adversities: A Cross-Sectional Study in Portugal

Addressing trauma has been found to be important for primary care patients, as it can improve their health-related outcomes. We aimed to assess how Portuguese general practitioners’ (GPs) past history of traumatic events (TEs) and adverse childhood experiences (ACEs) influence their clinical communication skills when addressing their patients’ past history of adversities. An online survey was circulated by email to GPs’ associations and through GPs’ social media groups. A sample of 143 GPs participated in this study. GPs’ exposure to ACEs and TEs was assessed using the Childhood Trauma Questionnaire-Short Form and the Life Events Checklist for the DSM-5. To evaluate clinical communication skills, we adapted the Self-confidence Scale and used the Jefferson Scale of Physician Empathy. GPs identified barriers to addressing trauma routinely, including a lack of time (86.7%) and a fear of causing further patient suffering (56.6%). GPs’ exposure to TEs and ACEs was positively correlated with scores in some dimensions of self-confidence and empathy (r values varying from 0.170 to 0.247). GPs exposed to traumatic experiences felt more confident when addressing their patients’ adversities and were more empathic when conducting therapeutic relationships. This study shows that GPs with a history of traumatic experiences are able to address their patients’ adversities; however, they lack proper training and better patient care conditions, such as more time and more resources available for patient guidance.
Detection and Classification of Objects in Synthetic Aperture Radar Imagery

Abstract : This is an amalgamation of a number of reports written by the author when he was contracted to DSTO through CSSIP. The reports concern the detection of faint trails, and the theory and evaluation of a number of existing and novel methods for the detection and classification of ground and maritime targets with SAR imagery. The publication of this collection allows the results to be available within defense and the wider community.
Function of Transcription Factors PoMYB12, PoMYB15, and PoMYB20 in Heat Stress and Growth of Pleurotus ostreatus

MYB transcription factors (TFs) have been extensively studied in plant abiotic stress responses and growth and development. However, the role of MYB TFs in the heat stress response and growth and development of Pleurotus ostreatus remains unclear. To investigate the function of PoMYB12, PoMYB15, and PoMYB20 TFs in P. ostreatus, mutant strains of PoMYB12, PoMYB15, and PoMYB20 were generated using RNA interference (RNAi) and overexpression (OE) techniques. The results indicated that the mycelia of OE-PoMYB12, OE-PoMYB20, and RNAi-PoMYB15 mutant strains exhibited positive effects under heat stress at 32 °C, 36 °C, and 40 °C. Compared to wild-type strains, the OE-PoMYB12, OE-PoMYB20, and RNAi-PoMYB15 mutant strains promoted the growth and development of P. ostreatus. These mutant strains also facilitated the recovery of growth and development of P. ostreatus after 24 h of 36 °C heat stress. In conclusion, the expression of PoMYB12 and PoMYB20 supports the mycelium’s response to heat stress and enhances the growth and development of P. ostreatus, whereas PoMYB15 produces the opposite effect.
Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults

To determine if creatine (Cr) supplementation could influence cognitive performance and whether any changes were related to changes in prefrontal cortex (PFC) activation during such cognitive tasks, thirty (M = 11, F = 19) participants were evenly randomized to receive supplementation with Cr (CR10:10 g/day or CR20:20 g/day) or a placebo (PLA:10 g/day) for 6 weeks. Participants completed a cognitive test battery (processing speed, episodic memory, and attention) on two separate occasions prior to and following supplementation. Functional near-infrared spectroscopy (fNIRS) was used to measure PFC oxyhemoglobin (O2Hb) during the cognitive evaluation. A two-way repeated measures ANOVA was used to determine the differences between the groups and the timepoints for the cognitive performance scores and PFC O2Hb. In addition, a one-way ANOVA of % change was used to determine pre- and post-differences between the groups. Creatine (independent of dosage) had no significant effect on the measures of cognitive performance. There was a trend for decreased relative PFC O2Hb in the CR10 group versus the PLA group in the processing speed test (p = 0.06). Overall, six weeks of Cr supplementation at a moderate or high dose does not improve cognitive performance or change PFC activation in young adults.
Effects of sports teaching models on different learning students’ domains: rationale and methodological protocol

ABSTRACT This study aimed to describe the methodological design of the Project entitled “Effects of the Sport Education Model (SEM) in Physical Education classes on physical, emotional, cognitive and socio-affective outcomes of students in different high school contexts”. An experimental study will be carried out with pre- and post-test measures in an experimental group (SEM) and in a comparator group (Traditional Teaching Model) randomized by clusters. The study hypothesizes that SEM will present positive and superior effects to the traditional model in all analyzed variables. The detailed description of the rationale and the methodological procedures of the Project will allow a better understanding of the results that will be presented after the end of the study.
Functional Alterations of the Basal Ganglia Are Associated with Voluntary Activation of the Core Stabilizing Muscles in Patients with Chronic Low Back Pain: A Cross-Sectional Study

Purpose Deficits in voluntary activation of the core stabilizing muscles are consistently observed in patients with chronic low back pain (CLBP); however, the underlying neural mechanism remains unclear. This cross-sectional study aimed at testing the hypothesis that the impaired voluntary activation of core stabilizing muscles is associated with structural and functional alterations in the basal ganglia, thalamus, and cortex in patients with CLBP. Methods We obtained structural and resting-state functional magnetic resonance imaging (rs-fMRI) data from 53 patients with CLBP and 67 healthy controls and estimated the alterations in grey matter volume (GMV) and functional and effective connectivity (EC) of regions with altered GMV via whole brain analysis. The voluntary activation of the multifidus (MF) and transversus abdominis (TrA) was evaluated by ultrasound imaging in these patients. Results Compared with the HCs, they displayed a significant decrease in GMV in the bilateral thalamus and caudate nucleus, a significant increase in GMV in the left middle frontal gyrus, and increased resting-state functional connectivity between the right caudate nucleus and the bilateral precuneus (voxel-level p < 0.005, Gaussian random field-corrected p < 0.05). The patients also showed increased EC from the right caudate nucleus to the bilateral precuneus, which was significantly correlated with voluntary activation of the bilateral MF and TrA (all p < 0.050). Conclusions Grey matter alterations may be confined to regions responsible for perception, motor control, and emotion regulation in patients with CLBP. The interrupted EC from the basal ganglia to the default mode network might be involved in the impairment of voluntary activation of the core stabilizing muscles.
Association between Dietary Vitamin E Intake and Human Papillomavirus Infection among US Adults: A Cross-Sectional Study from National Health and Nutrition Examination Survey

Persistent high-risk human papillomavirus (HPV) infection is responsible for most genital, anal, and oropharyngeal cancers, in which men contribute significantly to infection and subsequent tumorigenesis in women. Vitamin E has been shown to be associated with vaginal HPV infection and cervical cancer. However, the association of vitamin E consumption with HPV infection among the overall population remains unclear. We investigate the association between vitamin E consumption and genital and oral HPV infection in both men and women. We used cross-sectional data from the National Health and Nutrition Examination Survey between 2013 and 2016 to collect details on their dietary vitamin E intake, genital and oral HPV infection status, and other essential variables. In total, 5809 participants aged 18–59 years were identified, with overall prevalence of high-risk and low-risk HPV infection of 23.7% and 21.1%, respectively. Compared with the lowest vitamin E group Q1 (<5.18 mg/day), the adjusted OR for vitamin E consumption and overall high-risk HPV infection in Q2 (5.18–7.54 mg/day), Q3 (7.55–10.82 mg/day), and Q4 (>10.82 mg/day) were 0.91 (95% CI: 0.81–1.03, p = 0.134), 0.77 (95% CI: 0.69–0.87, p < 0.001), and 0.72 (95% CI: 0.65–0.80, p < 0.001), respectively. Restricted cubic spline regression showed a linear relationship between vitamin E consumption and overall high-risk HPV infection. This linear relationship also existed for vitamin E consumption and overall low-risk HPV infection. After being stratified by gender and site, vitamin E consumption was inversely related to vaginal low- and high-risk HPV infection, penile high-risk HPV infection, and male oral low-risk HPV infection. In conclusion, we identified inverse linear relationships between dietary vitamin E intake and overall high- and low-risk HPV infection. Future well-designed longitudinal studies are still required to validate the impact of vitamin E on HPV carcinogenesis.
Effect of Incorporation of Graphene Nanoplatelets on Physicochemical, Thermal, Rheological, and Mechanical Properties of Biobased and Biodegradable Blends

This work aimed to study the effect of the incorporation of graphene nanoplatelets (GRA 0.5% and 1% (w/w)) on the matrices of biobased polymers composed of starch-based materials (B20) and poly(butylene succinate) (PBS) using pine rosin (RES) as a compatibilizer. Three formulations were produced (B20/RES/PBS, B20/RES/PBS/GRA0.5%, and B20/RES/PBS/GRA1%), and their mechanical properties (tensile, flexural, hardness, and impact), rheological behavior, thermal properties (thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC)), chemical analysis (Fourier transform infrared-attenuated total reflectance (FTIR-ATR) spectroscopy), and contact angle were evaluated. Hardness (Shore D), tensile, and flexural moduli increased, whereas elongation at break and toughness decreased as GRA content increased. FTIR studies strongly supported the existence of interactions between polymeric matrices and the large surface area of GRA. The viscosity flow curves were well fitted to the Cross-Williams-Landel-Ferry (Cross-WLF) model, and the three formulations exhibited non-Newtonian (shear-thinning) behavior. The analysis of water contact angles indicated that the formulation surfaces have hydrophilic behavior. All the samples are thermally stable, and the results of this study can be used to optimize the application of biobased graphene-based composites for applications in injection molding industries.
Metallic Nanowires Self-Assembled in Quasi-Circular Nanomolds Templated by DNA Origami

The self-assembly of conducting nanostructures is currently being investigated intensively in order to evaluate the feasibility of creating novel nanoelectronic devices and circuits using such pathways. In particular, methods based on so-called DNA Origami nanostructures have shown great potential in the formation of metallic nanowires. The main challenge of this method is the reproducible generation of very well-connected metallic nanostructures, which may be used as interconnects in future devices. Here, we use a novel design of nanowires with a quasi-circular cross-section as opposed to rectangular or uncontrolled cross-sections in earlier studies. We find indications that the reliability of the fabrication scheme is enhanced and the overall resistance of the wires is comparable to metallic nanostructures generated by electrochemistry or top-down methods. In addition, we observe that some of the nanowires are annealed when passing a current through them, which leads to a clear enhancement for the conductance. We envision that these nanowires provide further steps towards the successful generation of nanoelectronics using self-assembly.
Road-Network-Map-Assisted Vehicle Positioning Based on Pose Graph Optimization

Satellite signals are easily lost in urban areas, which causes difficulty in vehicles being located with high precision. Visual odometry has been increasingly applied in navigation systems to solve this problem. However, visual odometry relies on dead-reckoning technology, where a slight positioning error can accumulate over time, resulting in a catastrophic positioning error. Thus, this paper proposes a road-network-map-assisted vehicle positioning method based on the theory of pose graph optimization. This method takes the dead-reckoning result of visual odometry as the input and introduces constraints from the point-line form road network map to suppress the accumulated error and improve vehicle positioning accuracy. We design an optimization and prediction model, and the original trajectory of visual odometry is optimized to obtain the corrected trajectory by introducing constraints from map correction points. The vehicle positioning result at the next moment is predicted based on the latest output of the visual odometry and corrected trajectory. The experiments carried out on the KITTI and campus datasets demonstrate the superiority of the proposed method, which can provide stable and accurate vehicle position estimation in real-time, and has higher positioning accuracy than similar map-assisted methods.
The Effect and Extent of Railroad Tie Drives in Streams of Southeastern Wyoming

Millions of railroad ties were floated (driven) down streams in southeastern Wyoming between 1868 and 1940. We identified 61 tie-driven streams in or near the Medicine Bow National Forest. We hypothesized that tie drives, and the stream clearing associated with driving, altered channel morphology and riparian vegetation. When comparing stream reaches of similar width and gradient, we found that tie-driven stream reaches contained less coarse woody debris and had significantly lower densities of large riparian trees than did unaffected reaches. Tie-driven reaches had lower channel complexity, a greater proportion of riffles, and fewer plunge and dammed pools than did unaffected reaches. We found significant relations among characteristics of the riparian trees, coarse woody debris, and stream channel structure. Recovery of the affected reaches may be contingent on the long-term increase in large trees in the riparian zone. West. J. Appl. For. 9(4): 125-130.
Recalibration of the Palaeocene-Eocene boundary (P-E) using high precision U-Pb and Ar-Ar isotopic dating

In the current time scales (Cande and Kent, 95; Berggren et al, 95) the P-E Boundary is positioned at 55 Ma based primarily on the age of the -17 ash layer in Denmark. In the absence of a global stratigraphic section and point the boundary is an interval of 1 m.y. from 55.5 to 54.5 Ma that includes all of the different means of calibrating the boundary tie point, including the NP9/NP10 calcareous nannofossil zonal boundary, the planktonic foraminiferal P5/P6a zonal boundary, preliminary ages for the -17 and +19 ash layers (unpub.), the base of the London Clay Formation, and the δC spike.
Numerical Investigation of Multiple Shock/Turbulent Flow Interaction in a Supersonic Channel

Numerical investigation of multiple shock/turbulent flow interaction is carried out using large eddy simulation for a supersonic channel flow with an inlet free stream Mach number 1.61. Various fundamental mechanisms dictating the flow phenomena including shock train, shear layer and turbulence behavior are investigated. It is found that the existence of the shock train and separated shear layer has an important influence on turbulence features. The turbulence intensities and turbulent kinetic energy (TKE) are strengthened in the region of the multiple shock because of the unsteadiness of the shocks. The investigation on the transport equations of the TKE and the pressure fluctuation reveals that the multiple shock and the roll-up vortices of shear layer can promote the generation of the TKE and the pressure fluctuation. The unsteady behavior of flow field is further analyzed by means of the proper orthogonal decomposition method. It is found that the multiple shock and the separated shear layer dominate the unsteady feature. AMS subject classifications: 76F65, 76L05, 76F70
Comparing the Effect of Repetitive Transcranial Magnetic Stimulation Therapy and Aerobic Exercise as an Add-on Therapy on the Cognitive Function of Patients with Depression

Background: Cognitive disturbances are a major cause of disability in depression. The antidepressant medication effectively improves cognitive function. However, its adverse effect limits its use, so add-on treatment is needed to support its effectiveness. Aim: This study aims to compare the efficacy of aerobic exercise and repetitive transcranial magnetic stimulation (rTMS) as an add-on treatment for improving cognitive function. Material and Methods: Twenty-seven patients with first episodes of moderate and severe depression were recruited from the outpatient psychiatry clinic to join this randomized controlled trial. Participants were allocated to three groups: antidepressant only, antidepressant with add-on aerobic exercise, and antidepressant with add-on rTMS therapy. All participants received 2 weeks of intervention. Cognitive functions were assessed using Montreal Cognitive Assessment (MOCA). Results: No differences were found in baseline characteristic data between groups. Total MOCA score increased after intervention in a group with no add-on treatment (p=0.007), with add-on aerobic exercise (p=0.011), and with add-on rTMS therapy (p=0.017). Hence, there was no between-group difference (p=0.222). The MOCA subtest analysis revealed between-group differences in changes in delayed recall subtest score (p=0.01). The group with add-on rTMS therapy improved better than the group with antidepressants only (p=0.005). Conclusion: The addition of rTMS therapy resulted in better improved delayed recall function than the addition of aerobic exercise or without any add-on treatment. This finding supports the application of rTMS therapy as an add-on treatment to improve the cognitive function of patients with depression.
FIRST MEASUREMENTS OF TROJAN HORSE INJECTION IN A PLASMA WAKEFIELD ACCELERATOR

Plasma accelerators support accelerating fields of 10-100’s of GV/m over meter-scale distances and routinely produce femtosecond-scale, multi-kA electron bunches. The so called Trojan Horse underdense photocathode plasma wakefield acceleration scheme combines state-of-the-art accelerator technology with laser and plasma methods and paves the way to improve beam quality as regards emittance and energy spread by many orders of magnitude. Electron beam brightness levels exceeding 1020 Am-2 rad-2 may be reached, and the tunability allows for multi-GeV energies, designer bunches and energy spreads <0.05% in a single plasma accelerator stage. The talk will present results of the international E210 multi-year experimental program at SLAC FACET, which cul-minated in successful first demonstration of the Trojan Horse method during FACET’s final experimental run in 2016. Enabling implications for applications, including high performance plasma-based 5th generation light sources such as hard x-ray FEL’s, for which preliminary start-to-end simulations are presented, and for high energy physics are discussed.