Miracle-dz/UniFAR-FTUs huggingface dataset:
Development and Optimization of High-Voltage Power Supply System for Industrial Magnetron

This paper describes the design and analysis of a 42-kW (14 kV, 3 A) high-voltage power supply for a 30-kW industrial magnetron drive. The design is based on a series resonant converter in discontinuous conduction mode (DCM) to take advantage of both the superior arc protection stemming from the current source characteristics and the high power density owing to the use of parasitic elements such as the leakage inductance in the high-voltage transformer. The detailed design procedure for the resonant tank and high-voltage transformer with respect to the input and output specifications is described on the basis of a simplified analysis of the DCM series resonant converter. Special considerations for designing high-power high-voltage power supplies are provided, such as series stacking of diodes for a voltage doubling rectifier and insulation between each winding of the high-voltage transformer. In addition, a comparative study using theoretical equations, simulation, and experimental results was carried out. This study yielded the output voltage and current characteristics at different switching frequencies and verified the advantages of this topology, such as arc protection without an additional protection circuit and high efficiency due to zero-current or zero-voltage switching. Moreover, the parallel operation of two converters with phase shifted gating signal is proposed to reduce the output current ripple and increase power capability for higher power magnetron drive. Additionally, the design considerations of two auxiliary power supplies (a filament power supply: 15 V, 150 A and a magnet power supply: 50 V, 5 A) are also provided and optimized for effective driving industrial magnetron. Finally, the developed power supply was tested with a 30-kW industrial magnetron, and the results prove the reliability and robustness of the proposed scheme.
Power signaling based cooperative precoding for the MISO interference channel

A new iterative method based on cooperative precoding for the two-user multiple-input single-output (MISO) interference channel (IC) is proposed. In contrast to existing methods, precoders are designed in order to maximize a lower bound of the sum rate. Useful and interference powers are exchanged between the transmitters at each iteration. Numerical results show performance improvements over non-cooperative and altruistic approaches.
Cleft Lip and Palate: An Experience of a Developing Center in Egypt

Background: Cleft lip and palate is the most common congenital anomaly in the head and neck region. These clefts are not just a distortion of the normal appearance, but they may impose a major influence on the whole patient's life, both functionally and psychologically. Clefts affect feeding, teething, hearing, speech, and social communication. The incidence of cleft lip and palate is variable in different countries and different communities. The surgical correction of cleft lip and palate went through many evolutions, but still there is no single universal protocol of repair; however, many European countries have adopted national protocols and have established cleft centers for the management and follow up of affected population. Patient and Methods: In this study, the problem of cleft lip and palate in the area of upper Egypt was presented through the records of patients admitted to the Department of Plastic Surgery at the Sohag University Hospital in a 15-year period (2001–2015). Results: A total number of 1318 patients, who were admitted and had been operated upon in our department, were included in this study. The majority of patients presented to the department with a primary disease, yet 14.7% (194 patients) of them were first presented for a secondary interference after being operated upon elsewhere. A total number of 1923 surgical procedures were performed.
Running with improved disturbance rejection by using non-linear leg springs

Most running robots and running models use linear leg springs. Non-linear leg springs have the potential to improve the performance of running robots and models, but it is not clear to what extent. In this paper, the effect of non-linear leg springs on disturbance rejection behavior is investigated. The optimal leg stiffness profile is determined by optimizing the gait sensitivity norm, a measure for disturbance rejection. The results of this optimization show that the optimal leg stiffness profile is strongly non-linear, and that the disturbance rejection is a factor of seven better than it would be with the optimal linear leg stiffness. The cause for this great improvement is that non-linear leg springs allow stable limit cycles that are much further away from the fall modes.
Psychiatric Psychopathology: A Practicum Approach

A graduate level didactic/experiential course in psychopathology has been offered at the University of West Florida since 1975. The focus of this course (titled "Practicum in Psychiatric Approaches to Psychopathology") is to introduce clinically-oriented psychology students to the applied and practical aspects of the field of psychiatry. The approach is a novel endeavor in light of the professional cleavage between clinical psychology and psychiatry. During the post-war era clinical psychology's identity emerged from the hallmark of psychodiagnostic assessment into the professionally prestigious role of psychotherapy. With the advent of this shift in professional practice, clinical psychology threatened the long-standing foundation of psychiatry's reign in the diagnosis and treatment of psychological disorders. To make matters more complicated, clinical psychologists have directed attention toward nee-behavioral approaches (e.g., cognitive-behavior therapy, community psychology) that depart from traditional clinical orientations. Meanwhile, psychiatry has maintained its focus on the psychodynamic/medical model as the basis for assessment of the vast spectrum of emotional, cognitive, and behavioral problems. Of course, the newly revised Diagnostic and Statistical Manual of the APA (DSM III) has attempted to clarify and differentiate more accurately clinical disorders. Further, the mental health field has today greatly expanded in terms of practitioners (e.g., social workers, nurses, counselors, rehabilitation specialists), client populations (e.g., learning disabled, the aged), and various psychotherapeutic modalities. Thus, the task of clinical educators, to provide a comprehensive approach toward the field of psychopathology, has become more complex over the years. For example, just ten years ago there were but a handful of texts on the subject of psychopathology. This list has now proliferated to include subjects in clinical assessment, behavior analysis, cognitive appraisals, and psychiatric foundations of both psychodynamic and nee-Freudian orientations, not to mention the new advances in neuropsychology and psychopharmacology. It is no surprise, therefore, that the integration of a psychological/psychiatric model as the basis for a "practical" course in psychopathology would be both challenging and nontraditional. Over the past eight years our course has been modified and improved to foster a unique practical learning experi-
VAP-1, a Novel Molecule Linked to Endothelial Damage and Kidney Function in Kidney Allograft Recipients

Background/Aims: VAP-1 (vascular adhesion protein-1) is a copper-containing SSAO (semicarbazide sensitive amine oxidase) secreted by vascular smooth muscle cells, adipocytes, endothelial cells with functional monoamine oxidase activity. The oxidation process generates harmful products that may be involved in atherosclerosis and vascular damage. Elevation of SSAO activity is observed in atherosclerosis, diabetes mellitus and obesity. On the other hand, renalase, with possible monoamine oxidase activity, which breaks down catecholamines like SSAO, is also expressed in the endothelium as well as in the kidney. The aim of the study was to assess VAP-1 levels and its correlations with endothelial injury markers and renalase in 50 kidney allograft recipients. Methods: Hemoglobin, urea, creatinine, rate were studied by standard laboratory method in the hospital central laboratory. We assessed markers of endothelial function/injury: vWF, thrombomodulin, ICAM, VCAM, CD40L, CD44, CD146, inflammation: hsCRP, and IL-6 and adipocytokines: leptin, adiponectin, visfatin, apelin with commercially available assays. Results: The mean serum VAP-1 in Tx was significantly higher comparing to the control group. In kidney transplant recipients VAP-1 correlated with BMI (r=0.39, p<0.01), CD44 (r=0.27, p<0.05), hsCRP (r=0.28, p<0.05), serum creatinine (r=0.29, p<0.05), eGFR (CKD-EPI formula r=-0.27, p<0.05, MDRD r=-0.27,p<0.05, Cockcroft-Gault r=-0.35,p<0.01), serum urea (r=0.27, p<0.05), CD146 (r=0.49, p<0.001), CD40L (r=0.26, p<0.06), and renalase (r=0.34, p<0.05). In multiple regression analysis VAP-1 was predicted 80% by serum creatinine (beta value 0.33, p=0.01), and CD146 (beta value 43, p=0.0005). Conclusion: VAP-1, elevated in kidney transplant recipients, is predominantly dependent on endothelial damage and kidney function, which deteriorated with time after kidney transplantation.
Marital Happiness and Sleep Disturbances in a Multi-Ethnic Sample of Middle-Aged Women

Previous research suggests that divorced individuals, particularly women, have higher rates of sleep disturbances as compared to married individuals. Among the married, however, little is known about the association between relationship quality and sleep. The present study examined the association between marital happiness and self-reported sleep disturbances in a sample of midlife women drawn from the Study of Women's Health Across the Nation (SWAN), a multi-site, multi-ethnic, community-based study (N = 2,148). Marital happiness was measured using a single item from the Dyadic Adjustment Scale, and sleep disturbance was assessed using 4 items from the Women's Health Initiative Insomnia Rating Scale (WHIIRS). After controlling for relevant covariates, maritally happy women reported fewer sleep disturbances, with the association evident among Caucasian women and to a lesser extent among African American women.
Deep Match between Geology Reports and Well Logs Using Spatial Information

In the shale oil & gas industry, operators are looking toward big data and new analytics tools and techniques to optimize operations and reduce cost. Formation evaluation is one of the most crucial steps before the fracturing operation. To assist engineers in understanding the subsurface and in turn make optimal operations, we focus on learning semantic relations between geology reports and well logs, which are collected during down-hole drilling. The challenges are how to represent the features of the geology reports and the well logs collected at measured depths and how to effectively embed them into a common feature space. We propose both linear and nonlinear (artificial neural network) models to achieve such an embedding. Extensive validations are conducted on public well data of North Dakota in the United States. We empirically discover that both geology reports and well logs follow a neighborhood property measured by geological distance. We show that this spatial information is highly effective in both the linear and nonlinear models and our nonlinear model with the spatial information performs the best among the state-of-the-art methods.
A secure multipath routing protocol in mobile ad hoc networks

Multipath routing can adapt to traffic changes, increase reliability and enhance the Quality of Service support in communication networks. This routing algorithm has been recognized as one of the salient features in Mobile Ad hoc Networks (MANETs). However, existing multipath routing protocols are often practically infeasible due to its security venerability if they suffer from attacks in MANETs, such as repudiation attacks, Denial of Service attacks. In this paper we propose a novel secure multipath routing protocol, referred to as SMRP, and investigate its feasibility and performance. SMRP applies a new heuristic algorithm increasing the number of disjoint paths and a smart authentication mechanism to enhance the security against the attacks in MANETs. The performance results from extensive analysis and experiments show that SMRP can efficiently enhance the security in MANETs while preserving the low overhead of computing and communication. Copyright © 2009 John Wiley & Sons, Ltd.
Interference avoidance resource allocation for D2D communication based on graph-coloring

In this paper, we propose an interference avoidance resource allocation scheme based on graph-coloring algorithm to introduce performance gain using spatial reuse in D2D (Device-to-Device) system. By assigning multiple D2D pairs to a single D2D resource, interference from neighboring D2D pairs is inevitable, which leads to performance degradation. Therefore, we first introduce the feedback method that can be practically provided by a D2D pair. Then, we propose a resource allocation scheme based on the graph-coloring theory, which is applied to efficiently avoid interference between D2D pairs. Simulation Results represent that the proposed resource allocation scheme outperforms conventional resource allocation schemes in both sum rate and outage probability of D2D pairs.
Article 14-3-3 σ , the double-edged sword of human cancers

14-3-3σ is a member of a highly conserved family of 14-3-3 proteins that are present in all eukaryotic organisms. 14-3-3σ has been considered as a tumor suppressor with reduced expression in some human cancers while its increased expression causes resistance to anticancer agents and radiation that cause DNA damages. The increased expression of 14-3-3σ may also predict poor prognosis in some human cancers. Thus, 14-3-3σ may play an important role as a double-edged sword in human cancers, which may attribute to its property as a molecular chaperone by binding to various protein ligands important to many cellular processes such as cell cycle checkpoint regulation and apoptosis in response to DNA damages. In this article, we will review recent studies and progresses in understanding 14-3-3σ as a double-edged sword in human cancers.
Glutamate Receptor Homologs in Plants: Functions and Evolutionary Origins

The plant glutamate-like receptor homologs (GLRs) are homologs of mammalian ionotropic glutamate receptors (iGluRs) which were discovered more than 10 years ago, and are hypothesized to be potential amino acid sensors in plants. Although initial progress on this gene family has been hampered by gene redundancy and technical issues such as gene toxicity; genetic, pharmacological, and electrophysiological approaches are starting to uncover the functions of this protein family. In parallel, there has been tremendous progress in elucidating the structure of animal glutamate receptors (iGluRs), which in turn will help understanding of the molecular mechanisms of plant GLR functions. In this review, we will summarize recent progress on the plant GLRs. Emerging evidence implicates plant GLRs in various biological processes in and beyond N sensing, and implies that there is some overlap in the signaling mechanisms of amino acids between plants and animals. Phylogenetic analysis using iGluRs from metazoans, plants, and bacteria showed that the plant GLRs are no more closely related to metazoan iGluRs as they are to bacterial iGluRs, indicating the separation of plant, other eukaryotic, and bacterial GLRs might have happened as early on as the last universal common ancestor. Structural similarities and differences with animal iGluRs, and the implication thereof, are also discussed.
Role of the N-terminal Transmembrane Region of the Multidrug Resistance Protein MRP2 in Routing to the Apical Membrane in MDCKII Cells*

In polarized cells, the multidrug resistance protein MRP2 is localized in the apical plasma membrane, whereas MRP1, another multidrug resistance protein (MRP) family member, is localized in the basolateral membrane. MRP1 and MRP2 are thought to contain an N-terminal region of five transmembrane segments (TMD0) coupled to 2 times six transmembrane segments via an intracellular loop (L0). We previously demonstrated for MRP1 that a mutant lacking TMD0 but still containing L0, called L0ΔMRP1, was functional and routed to the lateral plasma membrane. To investigate the role of the TMD0L0 region of MRP2 in routing to the apical membrane, we generated mutants similar to those made for MRP1. In contrast to L0ΔMRP1, L0ΔMRP2 was associated with an intracellular compartment, most likely endosomes. Co-expression with TMD0, however, resulted in apical localization of L0ΔMRP2 and transport activity. Uptake experiments with vesicles containing L0ΔMRP2 demonstrated that the molecule is able to transport LTC4. An MRP2 mutant without TMD0L0, ΔMRP2, was only core-glycosylated and localized intracellularly. Co-expression of ΔMRP2 with TMD0L0 resulted in an increased protein level of ΔMRP2, full glycosylation of the protein, routing to the apical membrane, and transport activity. Our results suggest that the TMD0 region is required for routing to or stable association with the apical membrane.
Band-structure calculations for Ni, Ni4H, Ni4H2, Ni4H3, and NiH.

We present a self-consistent calculation of the electronic structure of different nickel hydrides based on the linear-muffin-tin-orbital formalism and using the local-density approximation for the exchange and correlation. The calculations for the ground state show a continuous decrease of the saturation magnetization of Ni by increasing the hydrogen concentration as a result of changes in the exchange-splitting parameter and in the Fermi energy. The presence of hydrogen in the Ni matrix modifies the electronic states of the bulk. New impurity states appearing far below from the d band of the host are found in agreement with photoemission measurements. The density of states at the Fermi level increases as a function of the hydrogen concentration, giving in this way a greater \ensuremath{\gamma} coefficient for the electronic specific heat than that of pure Ni. The equilibrium lattice parameter of the various Ni hydrides also increases as a function of the hydrogen concentration, reaching a saturation value for a concentration of approximately 75 at. %. All features calculated are supported by experiments, and our first-principles calculation explains the increase of the electronic specific heat together with the loss of the ferromagnetism. We also found that the electronic density around the proton occupying the octahedral sites in the fcc Ni matrix is larger than that in the free atomic hydrogen. The electron transfer occurs from the Ni atoms to the hydrogen. The polarization of H in Ni is directed opposite to the bulk polarization and of the same order of magnitude as for positive muons in the same matrix. The hyperfine field of muon in Ni can be derived by use of the calculated values for the spin density around the proton and by taking into account the zero-point motion of the positive charge around its equilibrium position.
Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13

In Saccharomyces cerevisiae, Cdc13 has been proposed to mediate telomerase recruitment at telomere ends. Stn1, which associates with Cdc13 by the two‐hybrid interaction, has been implicated in telomere maintenance. Ten1, a previously uncharacterized protein, was found to associate physically with both Stn1 and Cdc13. A binding defect between Stn1‐13 and Ten1 was responsible for the long telomere phenotype of stn1‐13 mutant cells. Moreover, rescue of the cdc13‐1 mutation by STN1 was much improved when TEN1 was simultaneously overexpressed. Several ten1 mutations were found to confer telomerase‐dependent telomere lengthening. Other, temperature‐sensitive, mutants of TEN1 arrested at G2/M via activation of the Rad9‐dependent DNA damage checkpoint. These ten1 mutant cells were found to accumulate single‐stranded DNA in telomeric regions of the chromosomes. We propose that Ten1 is required to regulate telomere length, as well as to prevent lethal damage to telomeric DNA.
On evildoers: A Foucaultian analysis of the discursive structuring of contemporary terrorism

Terrorism is routinely portrayed in the twenty first century as an evil perpetrated by Arab/Muslim barbarians—Evildoers—waging a holy war against the Western civilisation. This study challenges not just this present understanding of terrorism, but the very existence of a ding an sich of terrorism. Using a combination of Foucault’s archaeological and genealogical methods it provides an alternative history of the phenomenon in the form of a history of its discursive structuring: the regimes of practices that governed what could and could not be thought of, identified, defined, known, judged and punished as ‘terrorism’ during particular epochs, and particular places. It asserts that the conceptual anchor point of the present Evildoer-terrorist is the rebel who opposes established order, and identifies the first such figure in modern Western history as the Devil who rebelled against God and came to play a significant politico religious role in Western societies of the Middle Ages. The discourse of ‘terrorism’ emerged from the epistemic spaces created from the separation of religion and politics in the eighteenth century, from when onwards rebellion was no longer a sin but a crime. Since then, various other rebels have been brought under the domain of terrorism during different epochs, the latest of whom is the Evildoer. This is not to say that the Devil remained a blatant constant in the forefront of Western terrorism discourse, but that the various rebels share a conceptual history that made it possible for the contemporary terrorist to be the Evildoer that he is. How the rebels came to be known as terrorists during various epochs and the various mechanisms implemented to defend societies against them, it is argued, are irrevocably linked: one could not exist without the other. The contemporary terrorist cannot be known as an Evildoer without the War on Terror; at the same time, the War on Terror cannot be waged without the knowledge of the terrorist as an Evildoer. To demonstrate this power/knowledge dyad at work, this study analyses what was said and done about terrorism by the United States and the United Kingdom, the foremost allies in the War on Terror, during its first ten years. In the differences in their discourses emerges not just the ontological uncertainty of terrorism but also how these mechanisms for establishing the ‘truth’ of terrorism function as mechanisms of power. It is asserted that the Evildoer has made possible, and was made possible by, some of the most significant changes in how power is exercised in Western societies since the separation of religion and politics in the eighteenth century.
Single Cell Transcriptomics: Methods and Applications

Traditionally, gene expression measurements were performed on “bulk” samples containing populations of thousands of cells. Recent advances in genomic technology have made it possible to measure gene expression in hundreds of individual cells at a time. As a result, cellular properties that were previously masked in “bulk” measurements can now be observed directly. In this review, we will survey emerging technologies for single cell transcriptomics, and describe how they are used to study complex disease such as cancer, as well as other biological phenomena such as tissue regeneration, embryonic development, and immune response.