Miracle-dz/UniFAR-FTUs huggingface dataset:
Duration of dual antiplatelet therapy after coronary artery stenting: where is the sweet spot between ischaemia and bleeding?

Permanent1 or transient2 intraluminal scaffolding of coronary arteries achieved by currently available stents effectively lowers the rate of acute vessel occlusion, persistent dissection, and restenosis.3 The latter complication is further reduced by local anti-proliferative drug delivery4 (drug eluting stent, DES), albeit delaying vascular healing with complete re-endothelialization. Blood exposed to foreign bodies may clot, which in case of coronary stent struts increases the risk of vascular occlusion (i.e. stent thrombosis, ST), myocardial infarction, and death. As ST is associated with high mortality, it is a feared complication of percutaneous coronary intervention (PCI). Anti-thrombotic therapy effectively reduces blood clotting and is mandatory during and after PCI. Platelet activation and aggregation on the stent surface is the main mechanism leading to ST. Pharmacological inactivation of the enzyme cyclooxygenase by its acetylation by acetylsalicylic acid (Aspirin®) and concomitant blockade of the P2Y12 receptor on the platelet surface by reversible or irreversible receptor antagonists (e.g. clopidogrel, ticagrelor, or prasugrel) effectively reduces platelet aggregation. A combination of these drug classes (i.e. dual antiplatelet therapy, DAPT) has become a cornerstone of post-PCI management5–7 and effectively reduces the risk of ST. After the roll-out of the first-generation DES (CYPHER® and TAXUS™), an increased incidence of late and very late ST was observed in comparison with bare metal stents.8,9 At the same time, there was no evidence available from randomized controlled trials (RTCs) defining the optimal duration of DAPT after DES implantation. Therefore, an arbitrary recommendation for 12 months DAPT after DES implantation was issued by guideline committees.10 In the meantime evidence has accumulated suggesting that in stable coronary …
The Politics of Class, Race, and Gender: Access to Higher Education in the United States, 1960-1986

This article, synthesizing the available (published and unpublished) evidence, describes patterns of inclusion of African-Americans, women, and working-class youth into the system of higher education from 1960 to 1986. Focusing not only on whether access has increased, but on whether these subordinate groups have gained access to elite institutions, this article examines the three groups in and across two periods (1960-76; 1976-86) to highlight differential patterns of access and to suggest a plausible explanation involving political mobilization to account for the observed trends. Although the general expansion of the system of higher education since 1960 has led to reduced differentials in access between dominant and subordinate groups, women and blacks--who mobilized--were able to gain access even to elite institutions. Workingclass youth did not experience such gains. A key factor that mediates these benefits of political mobilization is the recognition of the group as an official category in the society's system of classification. Using a variety of data sources, this article shows that, during times of both mobilization and countermobilization, access to particular levels of the higher education hierarchy generally follows the hypothesized directions. Further research that focuses on the precise mechanisms by which political mobilization produces the observed results is called for.
Levels of Serum Interleukin (IL)-6, IL-1β, Tumour Necrosis Factor-α and Leptin and Their Correlation in Depression

Objective: To investigate the relationship between leptin and cytokines in depressed patients. Methods: Thirty-three unmedicated patients (24 female, nine male) with depressive disorder and 23 healthy controls (16 female, seven male) were assessed for serum levels of interleukin (IL)-6, IL-1β, tumour necrosis factor-α (TNF-α) and leptin. Results: Levels of IL-6 and TNF-α in depressed patients were higher than in normal controls. There were significantly lower leptin levels in depressed patients than in normal controls. There were also significant differences in the leptin levels, being higher in female than in male patients, and in female than in male controls. Conclusions: IL-6 and TNF-α cytokines and leptin are important in the psychoimmunology of depressed patients. There were gender differences in leptin levels in depression.
Conceptualizing Organizational Climate.

Abstract : Part 1 of the paper presents some logical and conceptual distinctions between job satisfaction and organizational climate, the former being viewed as micro, evaluative, individual perceptions of personal events and experiences, the latter as macro, relatively descriptive, organization level perceptions that are abstractions of organizational practices and procedures. Part 2 proposes a formal definition of climate as meaningful perceptions or concepts people share and which function to help adapt people to an organization. The structuralism, functionalism and gestalt schools of psychology are each reviewed and the implications of each school for the definition of climate and climate research methods and theory are indicated. (Modified author abstract)
Digital image analysis of AgNORs in cervical smears of women with premalignant and malignant lesions of the uterine cervix

We performed a hospital-based, unmatched case-control study to investigate the association between progressive stages of cervical neoplasia and digital analysis of cell proliferation by silver stained nucleolus organizer region associated proteins (AgNORs). We measured cell proliferation levels in the cervical epithelial cells of 10 women with low grade squamous intraepithelial lesions (LG-SIL), eight with high grade squamous intraepithelial lesions (HG-SIL), 11 with cervical cancer (CC) and eight with no cervical lesions (controls) using the AgNORs technique. Cell proliferation was measured by digital image analysis (DIA). DIA revealed increased total areas of AgNORs in HG-SIL and CC compared to LG-SIL and control patients. AgNORs with a kidney or cluster shape exhibited greater areas than those with a spherical or long shape. We propose a cut-off of 118 pixels to differentiate benign (control and LG-SIL) from malignant (HG-SIL and CC) lesions. DIA of AgNORs is a simple and inexpensive method for studying proliferation. The increased total area of AgNORs in malignant lesions provides information regarding cell behavior and may be related to cervical carcinogenesis; however, further validation studies are required to establish its usefulness in cytological analysis.
Undue Influence as a Family Affair

Siblings sharing responsibility for parent care, and entitlement to parent assets, are sometimes dissatisfied with how their parents’ estates are distributed following a period of care to the parent. Such dissatisfaction can be advanced through legal claims by some siblings that other siblings, during the course of giving care, exerted undue influence over the parent to obtain their assets. The Canadian legal doctrine of undue influence directs attention to what transpired between two parties in the interest of protecting vulnerable people from having to honor arrangements to which they did not truly consent. In these cases, the focus is on the relationship between a sibling as an adult child, and the now deceased care recipient parent. At the same time, these cases reflect expectations and dynamics among siblings relative to each other. In this paper, a family, rather than dyadic, perspective is employed to illuminate elements of undue influence claims that are relevant to the sibling experience of giving care and sharing assets. We thus expand on understandings of dyadic issues addressed by the courts.
English and Spanish Versions of a Memory Test: Word-Length Effects Versus Spoken-Duration Effects

This article offers a methodological strategy to examine cross-language equivalence for tests measuring short-term memory (STM). The test used is the Rey Auditory-Verbal Learning Test (English version, RAVLT-E) and a Spanish translation (RAVLT-S). Two units of analysis to examine comparability were used: "word-length" (as measured by syllable count) and "spoken duration. " The participants were bilingual, Mexican American, male, college students. Although the word-length was considerably shorter in English than Spanish, the participants'performance on the RA VLT-Eand the RAVLT-S was not significantly different. Spoken duration quantification was not different between the two test versions. STM researchers and test developers need to be cautious about concluding, a priori, that translated Spanish STM tests (due to greater syllabic count) are inherently inequivalent to their English versions. It is recommended that both units of analysis-word length and spoken duration-be examined in such research.
Outsourced Proofs of Retrievability

Proofs of Retrievability (POR) are cryptographic proofs that enable a cloud provider to prove that a user can retrieve his file in its entirety. POR need to be frequently executed by the user to ensure that their files stored on the cloud can be fully retrieved at any point in time. To conduct and verify POR, users need to be equipped with devices that have network access, and that can tolerate the (non-negligible) computational overhead incurred by the verification process. This clearly hinders the large-scale adoption of POR by cloud users, since many users increasingly rely on portable devices that have limited computational capacity, or might not always have network access. In this paper, we introduce the notion of outsourced proofs of retrievability (OPOR), in which users can task an external auditor to perform and verify POR with the cloud provider. We argue that the OPOR setting is subject to security risks that have not been covered by existing POR security models. To remedy that, we propose a formal framework and a security model for OPOR. We then propose an instantiation of OPOR which builds upon the provably-secure private POR scheme due to Shacham and Waters (Asiacrypt'08) and we show its security in our proposed security model. We implement a prototype based on our solution, and evaluate its performance in a realistic cloud setting. Our evaluation results show that our proposal minimizes user effort, incurs negligible overhead on the auditor (compared to the SW scheme), and considerably improves over existing publicly verifiable POR.
Peace Profile: Vicent Martínez Guzmán

Vicent Martı́nez Guzmán is a Spanish born philosopher, educationalist, and activist of the international peace research movement. For more than 20 years his philosophical and educational views have been an unavoidable reference in the debates on the normative and epistemological foundations of what he calls “the task of making peace(s). ” Since the early 1990s, he has played a significant part in the development of interdisciplinary programs in Peace Studies in Spain. In 1999, he founded the UNESCO Chair of Philosophy for Peace at the University Jaume I, Castellón. His work in the fields of communication, linguistics, and education in the phenomenological tradition have contributed to our understanding of “conflict transformation,” while promoting a renovation in human and social sciences. Vicent built up a life that encompasses research, publishing, education, university management, and activism for peace. His advocacy for peace values based on “communicative solidarity” has had an extensive influence in academia, community life, and educational debates.
Unintentionality of affective attention across visual processing stages

Affective attention involves bottom-up perceptual selection that prioritizes motivationally significant stimuli. To clarify the extent to which this process is automatic, we investigated the dependence of affective attention on the intention to process emotional meaning. Affective attention was manipulated by presenting affective images with variable arousal and intentionality by requiring participants to make affective and non-affective evaluations. Polytomous rather than binary decisions were required from the participants in order to elicit relatively deep emotional processing. The temporal dynamics of prioritized processing were assessed using early posterior negativity (EPN, 175–300 ms) as well as P3-like (P3, 300–500 ms) and slow wave (SW, 500–1500 ms) portions of the late positive potential. All analyzed components were differentially sensitive to stimulus categories suggesting that they indeed reflect distinct stages of motivational significance encoding. The intention to perceive emotional meaning had no effect on EPN, an additive effect on P3, and an interactive effect on SW. We concluded that affective attention went from completely unintentional during the EPN to partially unintentional during P3 and SW where top-down signals, respectively, complemented and modulated bottom-up differences in stimulus prioritization. The findings were interpreted in light of two-stage models of visual perception by associating the EPN with large-capacity initial relevance detection and the P3 as well as SW with capacity-limited consolidation and elaboration of affective stimuli.
External Quality Auditing in Sweden: Are Departments Affected?

The article studies the effects of the first round of quality audits in five higher education institutions in Sweden. Using the formal objectives of the audits as a starting point of the investigation, the article examines in which areas change, as experienced at the departmental level, seems to be achieved and where problems can be found. The results are then discussed in a broader context where experiences from quality audit and assessment processes in the UK are included, and where strengths and weaknesses of the current audit procedures in Sweden are identified. Some implications of the study, especially focusing on possible future improvements in the design of quality audits, are examined in the conclusion.
Machine Learning — Final Project Report Online Email Spam Prediction

In this project, we study and experiment with a category of classification algorithms that are practically effective in email spam filtering—online prediction. We devise layered algorithms that can potentially control the spam misclassification rate. We compare the results of using different feature vectors as input. Also, we present observations that some online algorithms are insensitive to the order the samples are processed—misclassification rate can be probabilistically bounded irrelevant to incoming email order.
ADAS HMI using peripheral vision

We propose to enhance utility of Advance Driver Assistance Systems (ADAS) with an interface that creates luminous signals able to be handled by peripheral vision while driving. The system, called Lighting Peripheral Display (LPD), consists of a box illuminated by LEDs whose light is reflected onto the windscreen. The shapes of the box are designed so that reflections can easily match the problems signaled by the ADAS. Surface, colors and movements are modulated to graduate urgency and to discriminate between the different assistance systems. A user test has been done on a driving simulator to compare a cluster with and without LPD. Both subjective and objective data (oculometry, vehicle parameters) were collected. They show that driving performance and comfort are enhanced by LPD. Reaction time is reduced for the most frequent warnings; perceived utility of ADAS is increased. However, driver's eyes tend to look at LPD instead of the cluster; peripheral vision utilization is thus not validated but, as ocular path is smaller with LPD, it helps the driver to keep his vision on the road.
Vissage percutané du scaphoïde carpien par vis de Herbert - à propos de 10 cas

Les fractures du scaphoïde carpien sont de diagnostic et de traitement difficiles. Les auteurs rapportent les résultats du traitement de ces fractures par le vissage percutané par la vis de Herbert. Les résultats étaient intéressants vu la rapidité de consolidation et la qualité du résultat fonctionnel.
Influence of vocal effort on average and variability of fundamental frequency

Read and spontaneous speech was produced by 100 male adult speakers of German in a neutral setting and in a Lombard setting, where 80 dB noise was presented over headphones. Average f0 (‘f0mean’) and relative standard deviation of f0 (‘f0varco’) were determined for each speaker in each of the four conditions spontaneous neutral, spontaneous loud, read neutral and read loud. The results confirm that when increasing vocal effort from neutral to loud speech, f0mean increases as well. None of the 100 speakers posed an exception to this effect, but the size of the effect differed between speakers, even after differences in amplitude level were accounted for. F0varco was significantly higher in loud than normal speech for the reading task, whereas in spontaneous speech no significant difference occurred. These results are compared with the literature and discussed with respect to explanations and forensicphonetic implications.
Using Refactoring and Unification Rules to Assist Framework Evolution

Although object-oriented software development has experienced the benefits of using frameworks, a thorough understanding of how to change them to meet evolving requirement needs is still object of research. Therefore framework development is very expensive, not only because of the intrinsic difficulty related to capturing the domain theory, but also because of the lack of appropriate methods and techniques to support the evolution and redesign of the framework architecture. This paper proposes the use of refactoring and unification rules to assist framework evolution. The approach is illustrated through the JUnit testing framework.
Successful after-school physical activity clubs in urban high schools: Perspectives of adult leaders and student participants

Grounded in social cognitive theory, the purpose of this study was to examine leaders’ and students’ perspectives of factors that contribute to effective voluntary after-school physical activity clubs. Data were collected over two-years via field observations (n= 115) and interviews with students (n = 278) and adult leaders (n = 126). Results highlighted interconnections among personal and environmental facilitators such as enthusiastic and caring leaders, multidimensional recruiting strategies, supportive and friendly club climates, and culturally relevant physical activities. Structural barriers such as a lack of administrative support, student hunger, and inadequate transportation options were also identified by leaders and students. While previous after-school physical activity club research has focused primarily on measuring physical activity increases, these students and leaders voiced valuable perspectives that contribute to understand why some initiatives fail and others succeed from a social cogn.
Stimulation over the human supplementary motor area interferes with the organization of future elements in complex motor sequences.

We used high-frequency repetitive transcranial magnetic stimulation (rTMS) to study the role of the mesial frontocentral cortex (including the supplementary motor area) in the organization of sequential finger movements of different complexity in humans. In 15 subjects, rTMS was randomly applied to the scalp overlying the region of the supplementary motor area and over other positions, including the contralateral primary motor cortex (hand area) during the performance of three overlearned finger sequences on an electronic piano. In all trials, rTMS (frequency 15-20 Hz) started 2 s after the first key press and lasted for approximately 2 s. All sequences were metronome-paced at 2 Hz and retrieved from memory. The 'simple' sequence consisted of 16 repeated index finger key presses, the 'scale' sequence of four times four sequential key presses of the little, ring, middle and index fingers, and the 'complex' sequence of a much less systematic and, therefore, more difficult series of 16 key presses. To measure the effects of rTMS interference with regional cortical function, we analysed rTMS-induced accuracy errors in the movement sequences. Stimulation over the supplementary motor area induced accuracy errors only in the complex sequence, while stimulation over the primary motor cortex induced errors in both the complex and scale sequences, and stimulation over other positions (e.g. F3, F4, FCz, P3, P4) did not interfere with sequence performance at all. Stimulation over the supplementary motor area interfered with the organization of subsequent elements in the complex sequence of movements, with error induction occurring approximately 1 s later than with stimulation over the primary motor cortex. Our findings are in keeping with recent results in non-human primates (Tanji J, Shima K. Nature, 1994; 371: 413-6) indicating a critical role of the supplementary motor area in the organization of forthcoming movements in complex motor sequences that are rehearsed from memory and fit into a precise timing plan.
Mental health legislation in the commonwealth

Purpose of review Mental health law is changing in some common law jurisdictions. Questions are being asked about whether special legislation is still needed, whether it is a health or a legal issue, and how this part of the law relates to cognate laws about patient consent to healthcare and determinations about competence. The role of tribunal or court adjudication of the need for admission is also debated, along with the capacity of the law to harness resources or manage care. It is therefore timely to review these debates. Recent findings Renewed support is evident in the literature for subsuming mental healthcare within the general laws governing consent to care or determinations of competence. Socio-legal and interdisciplinary research suggests that health perspectives are already quite dominant in mental health law, while involuntary detention may correlate poorly with levels of need. The mesh between the law and service systems remains problematic, and there is little evidence that law has yet developed a significant capacity for leveraging treatment resources. Summary This review suggests that the priority for future research lies in exploring the factors which enhance treatment access and outcomes for the mentally ill rather than debating the shape or content of mental health law.