Miracle-dz/UniFAR-FTUs huggingface dataset:
Primary mediastinal large B-cell lymphoma with sclerosis in pediatric and adolescent patients: treatment and results from three therapeutic studies of the Berlin-Frankfurt-Münster Group.

PURPOSE Primary mediastinal large B-cell lymphoma with sclerosis (PMLBL) is a rare entity of non-Hodgkin's lymphoma (NHL) arising from thymic mature B cells. Optimal treatment strategies remain to be established, especially in pediatric patients. PATIENTS AND METHODS This study analyzes clinical characteristics and treatment outcome of 30 pediatric patients with PMLBL, diagnosed in multicenter therapy NHL-Berlin-Frankfurt-Münster Group (BFM) trials. Treatment was stratified by stage and serum lactate dehydrogenase (LDH) and consisted of four to six 5-day courses of chemotherapy using steroids, oxazaphosphorine alkylating agents, methotrexate, cytarabine, etoposide, and doxorubicin. Radiation was not part of the protocol. RESULTS From April 1986 to August 1999, 1,650 patients with newly diagnosed NHL were enrolled in the NHL-BFM trials; 30 patients (1.8%) had PMLBL. Median age was 14.3 years (range, 1.4 to 16.7 years); 15 patients were male and 15 patients were female. With a median observation time of 5 years (range, 1 to 12 years), probability of event-free survival (pEFS) at 5 years was 0.70 (SE, 0.08). Two patients erroneously diagnosed as T-cell NHL received non-B-cell therapy and died from progress of disease. Events in 28 patients receiving B-cell therapy included early progress during therapy (n = 1) and relapse (n = 6). Residual mediastinal masses were present in 23 patients after two courses of therapy and in 15 patients after the end of therapy. LDH > or = 500 U/L was associated with increased risk of failure in multivariate analysis. CONCLUSION PMLBL mainly is found in adolescents. Dose-intense chemotherapy including high-dose methotrexate yields a pEFS at 5 years of 0.70 (SE, 0.08). LDH is of prognostic value in pediatric patients with PMLBL.
The Forkhead Transcription Factor FoxC2 Inhibits White Adipocyte Differentiation*

In this study, we show that expression of FoxC2 blocks the capacity of 3T3-L1 preadipocytes to undergo adipogenesis in the presence of dexamethasone, isobutylmethylxanthine, and insulin. This block is characterized by an extensive decrease in the expression of proteins associated with the function of the mature fat cell, most notably C/EBPα, adiponectin, perilipin, and the adipose-specific fatty acid-binding protein, FABP4/aP2. Since the expression of these proteins lies downstream of PPARγ, we overexpressed PPARγ in Swiss mouse fibroblasts to promote adipocyte differentiation. We show that FoxC2 blocks the ability of PPARγ to induce adipogenic gene expression in response to exposure of the cells to dexamethasone, isobutylmethylxanthine, insulin, and a PPARγ ligand. Interestingly, the expression of aP2 escapes the inhibitory action of FoxC2 under conditions that promote maximum PPARγ activity. In contrast, FoxC2 inhibits the expression of C/EBPα, perilipin, and adiponectin even in the presence of potent PPARγ ligands. Finally, we show that FoxC2 does not affect the ability of PPARγ to bind to or transactivate from a PPARγ response element. These data suggest that FoxC2 blocks adipogenesis by inhibiting the capacity of PPARγ to promote the expression of a subset of adipogenic genes.
Glutathione peroxidase activities in serum and cerebrospinal fluid from patients with acute lymphocytic leukemia

von Willebrand factor antigenic dosage: 10%). DDAVP therapy was ineffective. Post viral hepatitis mild liver cirrhosis developed. The first recurrent bleeding complications occurred in 1984; these remained unexplained. From September 1991, severe bleeding episodes (he-matemesis and melena) developed, requiring repeated red blood cell trans-fusions and von Willebrand factor concentrate injections. At this time, several esogastroscopies and colonoscopies showed the presence of multiple digestive angiodysplastic lesions. Some of them were treated by laser, but bleeding episodes recurred, with life threatening intensity (9 episodes over a 9-month period, requiring the transfusion of 18 packed red cells units, 10 of them during one episode). On the endoscopic control performed in May 1992, diffuse angiodysplastic lesions were noted on the colonic wall and the terminal ileum. A hormonal therapy was then started (norethisterone 1 mg; ethinylestradiol 0.05 mgiday). Bleeding episodes disappeared immediately, and in an 18-month period only one moderate bleeding episode was noted. The last endoscopic examination revealed only small duodenal lesions: colonic examination was normal. No humoral hepatic disturbance has been noted to date, a-fetoprotein level remaining within a strictly normal range. Hepatic echography remains normal. The sole side effects noted were significant gynecomastia and impotence. von Willebrand factor level was not notified by hormonal therapy. This case inspired us with some comments:
Cross-signaling between L-type Ca2+ channels and ryanodine receptors in rat ventricular myocytes

Calcium-mediated cross-signaling between the dihydropyridine (DHP) receptor, ryanodine receptor, and Na(+)-Ca2+ exchanger was examined in single rat ventricular myocytes where the diffusion distance of Ca2+ was limited to < 50 nm by dialysis with high concentrations of Ca2+ buffers. Dialysis of the cell with 2 mM Ca(2+)- indicator dye, Fura-2, or 2 mM Fura-2 plus 14 mM EGTA decreased the magnitude of ICa-triggered intracellular Ca2+ transients (Cai-transients) from 500 to 20-100 nM and completely abolished contraction, even though the amount of Ca2+ released from the sarcoplasmic reticulum remained constant (approximately 140 microM). Inactivation kinetics of ICa in highly Ca(2+)-buffered cells was retarded when Ca2+ stores of the sarcoplasmic reticulum (SR) were depleted by caffeine applied 500 ms before activation of ICa, while inactivation was accelerated if caffeine- induced release coincided with the activation of ICa. Quantitative analysis of these data indicate that the rate of inactivation of ICa was linearly related to SR Ca(2+)-release and reduced by > 67% when release was absent. Thapsigargin, abolishing SR release, suppressed the effect of caffeine on the inactivation kinetics of ICa. Caffeine- triggered Ca(2+)-release, in the absence of Ca2+ entry through the Ca2+ channel (using Ba2+ as a charge carrier), caused rapid inactivation of the slowly decaying Ba2+ current. Since Ba2+ does not release Ca2+ but binds to Fura-2, it was possible to calibrate the fluorescence signals in terms of equivalent cation charge. Using this procedure, the amplification factor of ICa-induced Ca2+ release was found to be 17.6 +/- 1.1 (n = 4). The Na(+)-Ca2+ exchange current, activated by caffeine- induced Ca2+ release, was measured consistently in myocytes dialyzed with 0.2 but not with 2 mM Fura-2. Our results quantify Ca2+ signaling in cardiomyocytes and suggest the existence of a Ca2+ microdomain which includes the DHP/ ryanodine receptors complex, but excludes the Na(+)- Ca2+ exchanger. This microdomain appears to be fairly inaccessible to high concentrations of Ca2+ buffers.
High frequency transformer based on a coupled inductor topology with dielectric isolation

This paper presents a new high-frequency coupled inductor topology in conjunction with a dielectric isolation device which provides improved efficiency and reduced input currents over conventional magnetic transformers. The main focus of the paper will be the design and operation of this new passive hybrid system, along with a comparison with a regular magnetic high frequency transformer based on simulations and experimental results.
Thyroid hormones and thermogenesis

An extensive review article on thyroid hormone published nearly 40 years ago (Barker, 1951) might have led one to suppose that little could be added to the subject of thyroid hormones and thermogenesis. However, a large number of new ideas have since emerged with respect to the mechanisms of action of thyroid hormones, although there is still considerable uncertainty as to how they function at the cellular level to increase metabolic rate. In addition, major advances have been made with respect to the extent that environmental factors such as temperature and nutrition can influence thyroid hormone metabolism. but rather to consider specific related to in which, unlike does not to a Second, their mechanism of action in elevating resting metabolic Finally, to which hormones will be
An Authentication System for Digital Images

The ability to modify digital images can cause a s erious problem in some applications. In recent year s, considerable amount of research has been directed t owards developing methods that would protect the au thenticity of digital images. The major part of this research has been devoted to obtaining an understanding of t he information theory involved and only a small part of it has bee n focused on the actual implementation of the metho ds. A workable authentication system that would be secure and ready for use in a wide range of applications s still to be made. In this paper we propose a novel method deriv ed from the Wong's authentication scheme that is ca pable of authenticating JPEG images as well as uncompressed images, but is not a watermarking method. Our metho d offers great flexibility in terms of the size of the authe nticator and the time needed to generate the authen ticator, thus making it suitable for real-time image processing. We demonstrate this by implementing a simplified ve rsion of the authentication unit in a programmable FPGA circuit.
Visual servoing for robot-assisted diagnostic ultrasound

A robot system for positioning an ultrasound probe has been developed. Ultrasound visual servoing can be used to help ultrasound technicians position the ultrasound probe. The feasibility of visual servoing for motion in the plane of the ultrasound probe in one dimension has been addressed here. Tracking of the carotid artery for a long period of time has been demonstrated in real-time. Two different image processing methods have been evaluated, namely, the Star algorithm and a modified discrete snake algorithm.
Structural aberrations of the long arm of chromosome no. 22: Report of a family with translocation t(11;22) (q25;q11) *

A chromosomal translocation t(11;22) (q25;q11) is described in a family. Four members, in two generations, had the same translocation but showed phenotypic variation. Case reports of chromosome aberrations involving the long arm of chromosome 22 associated with and without chronic myeloid leukemia (CML) are reviewed. It appears that the distal segment of the long arm of chromosome 22 is either translocated or deleted, resulting in congenital anomalies, presumably due to chromosome imbalance. In other instances, a specific breakpoint on 22q results in the origin of Philadelphia chromosome (Ph1) associated with CML.
A HDV Acquisition and Process Solution for Mine Black Environment

Abstract-For the problems that bad imaging result, small adapt range of optical and can't work under the low light intensity mine environment in the existing solutions and products, we proposed a HDV acquisition, process and wireless transmit ion solution that accords with the intrinsically security standard for the low light intensity environment, including two aspects: HDV acquisition front-end and mine media data process terminal. The HDV Acquisition Front-end used the technology of low light night vision with the white light assistant illumination that coupled the image intensifier and CMOS image sensor module directly; Multimedia data process terminal under mine takes the S3C6410 based on ARM11 as the CPU to achieve the video signal process and wireless transmit ion following the Wi-Fi and Mini USB communication protocols. Ground on this solution, we designed the mine Media data process system that the Power part used the low voltage design, which fulfilled the intrinsically safe standard and came out the low power of device. The test results showed that this system can implement the high-definition video images collection, compression and storage within the scope of illumination 10-4 ~ 102Lux.
Glycodelin in ovarian serous carcinoma: association with differentiation and survival.

Ovarian cancer consists of many subtypes, serous carcinoma being the most common of them. In addition to the histopathological subtype, grading, clinical staging, and the amount of residual tumor, a great number of putative prognostic markers have been introduced. This study addresses in ovarian serous carcinoma the role of glycodelin, the major progesterone-regulated lipocalin protein of the reproductive axis with diverse actions in cell recognition and differentiation. Glycodelin expression was determined by immunohistochemistry of tissue microarrays in ovarian serous carcinomas from 460 patients, and the results were analyzed with respect to progesterone receptor subtype A (PRA) and progesterone receptor subtype B (PRB), clinical parameters, and survival. Glycodelin was localized to the cytoplasm of tumor cells, whereas vascular endothelium in tumor tissue was glycodelin-negative. Glycodelin expression was more frequent in well-differentiated (grade I, 79%) than in poorly differentiated carcinomas (grade III, 51%; P < 0.0001), and it was also more frequent in early-stage compared with advanced-stage carcinomas (P = 0.002). Nuclear PRA and PRB were often coexpressed with cytoplasmic glycodelin. Although this was not consistent in all tumors, there was a positive correlation between the presence of glycodelin and PRs in the tumor (P < 0.02), but not between the presence of, or the absence of, glycodelin in tumor and the CA-125 serum concentration. Although in multivariate analysis glycodelin was not an independent variable, the patients with glycodelin-expressing tumors showed a higher 5-year overall survival compared with those with glycodelin-negative tumors (55 versus 39%; P < 0.0001; hazard ratio in univariate analysis, 0.57; confidence interval, 0.44-0.74). This difference was notable in patients with grade I tumors and stage III disease. In the latter group, the 10-year survival probability of patients with glycodelin-positive tumors was more than twice as high as that in women with glycodelin-negative tumors. This was also found within well-defined clinical categories, e.g., stage III/grade II and stage III/grade III carcinomas, in which patients with glycodelin-positive tumors carried significantly better 10-year overall survival compared with those with glycodelin-negative tumors. It is concluded that, in ovarian serous carcinoma, glycodelin expression portends better prognosis, probably because of its differentiation-related disposition.
Transplantation for thalassemia major: alternative donors

Purpose of reviewLack of a human leukocyte antigen (HLA)-matched family donor is a major obstacle limiting the use of allogeneic hematopoietic stem cell transplantation (HSCT) to cure thalassemia major. Use of alternative donors, if found well tolerated enough, may be a viable option for transplantation in this setting, allowing to expand the number of patients treatable by HSCT. This review will provide an overview of alternative HSCT approaches in thalassemia major. Recent findingsWith the introduction of high-resolution molecular HLA-typing techniques, the outcome of matched unrelated donor HSCT recipients has become comparable with that of patients given matched family donor HSCT. On the contrary, the use of unrelated cord blood transplantation has been limited by the risk of graft failure and slow hematopoietic recovery, although novel techniques of ex vivo graft manipulation are emerging as promising strategies for overcoming these obstacles. Although experience with haploidentical HSCT in thalassemia major is still limited, currently explored platforms hold the potential to extend the access to HSCT to thalassemia major patients lacking an HLA-matched either related or unrelated donor. SummaryThe significant advances achieved in transplantation techniques, both in the matched unrelated and in the haploidentical setting, are expected to significantly broaden the applicability of HSCT to patients with thalassemia major.
Conception d'une unité mobile de production pour produit reconfigurable

Le concept de mobilite de systeme de production presente une solution pour reduire le cout de production d'un produit fabrique en serie, destine a plusieurs clients (sites d'implantation du systeme de production) dont l'utilisation releve d'un site particulier qui se distingue des autres par des caracteristiques specifiques. Le systeme de production, par sa mobilite, doit etre capable de s'adapter et de repondre aux contraintes des sites d'implantation et aussi de satisfaire aux exigences du produit. Cette communication adresse les problematiques introduites par la notion d'un environnement multisite dans les interactions produit reconfigurable/ systemes de production mobile. Plusieurs points de vue seront adoptes afin de definir les criteres de performance de l'unite mobile de production.
Università Della Svizzera Italiana Usi Technical Report Series in Informatics Abstraction and Acceleration in Smt-based Model-checking for Array Programs

ion (in its various forms) is a powerful established technique in model-checking; still, when unbounded data-structures are concerned, it cannot always cope with divergence phenomena in a satisfactory way. Acceleration is an approach which is widely used to avoid divergence, but it has been applied mostly to integer programs. This paper addresses the problem of accelerating transition relations for unbounded arrays with the ultimate goal of avoiding divergence during reachability analysis of abstract programs. For this, we first design a format to compute accelerations in this domain; then we show how to adapt the so-called 'monotonic abstraction' technique to efficiently handle complex formulae with nested quantifiers generated by the acceleration preprocessing. Notably, our technique can be easily plugged-in into abstrac-tion/refinement loops, and strongly contributes to avoid divergence: experiments conducted with the MCMT model checker attest the effectiveness of our approach on programs with unbounded arrays, where acceleration and abstraction/refinement technologies fail if applied alone.
New lipoprotein profiles and coronary heart disease. Improving precision of risk.

C ardiologists and clinicians have in general accepted the significance of a raised plasma cholesterol concentration. Doubters notwithstanding, most cardiologists will advise cholesterol-lowering measures if low density lipoprotein (LDL) levels are high, particularly in the presence of other risk factors for cardiovascular disease. Most would also agree that risk must be maximally reduced after coronary artery bypass grafting or angioplasty. Clinicians have also come to recognize the need to take into account the concentration of high density lipoprotein (HDL).
SOCIAL AND EMOTIONAL BEHAVIOR IN INFANCY--SOME DEVELOPMENTAL ISSUES AND PROBLEMS.

tional development in infancy. A number of excellent reviews and discus sions of some of the most salient topics in this broad area have appeared within the past several years (e.g., Yarrow's review of the effects of ma ternal separation (1964), Bronfenbrenner's paper on early deprivation in mammals and man (1968), Rheingold's discussion of the development of social behavior in infancy (1966), etc.). Rather, my main purpose will be to point out and discuss what seem to me to be some important current research issues and areas of investigation which hold particular promise for advancing our understanding of the nature and development of social and emotional behavior in human infancy. At the same time, I would like to indicate both the historical contrast, as well as the continuity, between these contemporary research issues and those which represented some of the main concerns of earlier investigators in the field of child development. I shall therefore precede my discussion of current research emphases with a brief summary of the early descriptive studies of social and emotional behavior and development in infancy. Some definitional notes
Task-Driven Color Coding

Color coding is a widely used visualization method for scalar data. To generate expressive and effective visual representations, it is extremely important to carefully design the mapping from data to color. In this paper, we describe a color coding approach that accounts for the different tasks users might pursue when analyzing data. Our task description is based on the task model of Andrienko & Andrienko. We apply different color scales and introduce strategies to adapt the color mapping function to support tasks like comparison, localization, or identification of data values.
Low-Loss Amorphous Silicon Channel Waveguides for Integrated Photonics

Amorphous silicon (a-Si), single-mode, channel waveguides were fabricated and measured with transmission losses as low as 6.5 dB/cm for the TE mode and 4.5 dB/cm for the TM mode. Variations in the PECVD a-Si deposition conditions yielded a-Si materials with bulk losses <1 dB/cm
Queueing system with passive servers

In this paper the authors introduce systems in which customers are served by one active server and a group of passive servers. The calculation of response time for such systems is rendered by analyzing a special kind of queueing system in a synchronized random environment. For an embedded Markov chain, sufficient conditions for the existence of a stationary distribution are proved. A formula for the corresponding vector generating function is obtained. It is a matrix analog of the Pollaczek-Khinchin formula and is simultaneously a matrix functional equation. A method for solving this equation is proposed.
Serum Aldosterone Concentrations and Urine Output in Oliguric Intensive Care Unit Patients Receiving Low-Dose Dopamine

OBJECTIVE: To determine whether the diuretic and natriuretic effects of low-dose dopamine (2.5 μ/kg/min) are associated with changes in serum aldosterone concentration. DESIGN: Prospective clinical study. SETTING: Surgical intensive care unit (SICU) of a university hospital. PARTICIPANTS: Oliguric (urine output <0.5 mL/kg/h) SICU patients. All patients were resuscitated to pulmonary artery occlusion pressure > 10 mm Hg, mean arterial pressure >65 mm Hg, and cardiac index >2.5 L/min/m2. Patients with a serum creatinine concentration > 176.8 μmol/L (2.0 mg/dL.), those who received diuretics within 12 hours prior to entry into the study, and renal transplant recipients were excluded. MAIN OUTCOME MEASURES: Hourly urine output (mean ± SD) was recorded 2 hours before and for 6 hours after the initiation of lowdose dopamine. Urine sodium and serum aldosterone concentrations were obtained prior to and 6 hours after the start of low-dose dopamine. RESULTS: Fifteen patients were enrolled in the study. Urine output (mean ±SD) increased from 0.31 ± 0.11 mL/kg/h before to 0.80 ± 0.34 mL/kg/h following low-dose dopamine (p<0.01). Urine sodium concentrations increased from 46 ± 32 mmol/L baseline to 72 ± 53 mmol/L following low-dose dopamine (p<0.05), and serum aldosterone concentrations decreased from 415.82 ± 341.48 pmol/L prior to low-dose dopamine infusion to 256.04 ± 204.17 pmol/L (p<0.05). Cardiac output, pulmonary artery occlusion pressure, mean arterial pressure, and heart rate did not change. CONCLUSIONS: Low-dose dopamine significantly increases urine output and urine sodium excretion in oliguric, critically ill, surgical patients, and is associated with a decrease in serum aldosterone concentration. The diuretic and natriuretic effects of low-dose dopamine may be, in part, related to a dopamine-mediated inhibition of aldosterone secretion.