Miracle-dz/UniFAR-FTUs huggingface dataset:
A Conceptual Model of Adaptive Protective Factors for Migrant Workers

About 450 million of 1.2 billion Indians migrated within the country, according to recently released Census 2011 data. Of this, 78 million, or 15.6% of all domestic migrants, moved from rural to urban areas. This is how their numbers have changed over 2001 and where they moved. Migrant workers show an enhancement in the occurrence of stern maladaptation to the host cities due to slaughter of social eminence, inequity and parting from the family. Several migrant workers are not entitled to avail of basic facilities such as education, social security, housing and medical benefits. Using a resilience perspective, this study attempted to find out adaptive protective factors responsible for the resilience of migrant labour in the host city. Data was collected through an interview schedule by using a structured questionnaire on 240 migrant workers in the Tiruchirappalli district of Tamil Nadu. The questionnaire was constructed on demographic characteristics and different dimensions of adaptive protective factors such as structural adaptation, labour market competitiveness, opportunity for informal entrepreneurship, language acquisition and access to mobility on the seven-point Likert scale. By doing structural equation modelling (SEM) analysis and confirmatory factor analysis (CFA), it is found that favourableness in structural adaptation and opportunity for informal entrepreneurship stood out as the most predictive adaptive protection factors along with language acquisition, access to mobility and level of competitiveness in the labour market for migrant workers.
Pharmacophore Modeling Using Machine Learning for Screening the Blood–Brain Barrier Permeation of Xenobiotics

Daily exposure to xenobiotics affects human health, especially the nervous system, causing neurodegenerative diseases. The nervous system is protected by tight junctions present at the blood–brain barrier (BBB), but only molecules with desirable physicochemical properties can permeate it. This is why permeation is a decisive step in avoiding unwanted brain toxicity and also in developing neuronal drugs. In silico methods are being implemented as an initial step to reduce animal testing and the time complexity of the in vitro screening process. However, most in silico methods are ligand based, and consider only the physiochemical properties of ligands. However, these ligand-based methods have their own limitations and sometimes fail to predict the BBB permeation of xenobiotics. The objective of this work was to investigate the influence of the pharmacophoric features of protein–ligand interactions on BBB permeation. For these purposes, receptor-based pharmacophore and ligand-based pharmacophore fingerprints were developed using docking and Rdkit, respectively. Then, these fingerprints were trained on classical machine-learning models and compared with classical fingerprints. Among the tested footprints, the ligand-based pharmacophore fingerprint achieved slightly better (77% accuracy) performance compared to the classical fingerprint method. In contrast, receptor-based pharmacophores did not lead to much improvement compared to classical descriptors. The performance can be further improved by considering efflux proteins such as BCRP (breast cancer resistance protein), as well as P-gp (P-glycoprotein). However, the limited data availability for other proteins regarding their pharmacophoric interactions is a bottleneck to its improvement. Nonetheless, the developed models and exploratory analysis provide a path to extend the same framework for environmental chemicals, which, like drugs, are also xenobiotics. This research can help in human health risk assessment by a priori screening for neurotoxicity-causing agents.
Stability Theory: An Introduction to the Stability of Dynamic Systems and Rigid Bodies

This book describes a unified theory of stability for systems of rigid bodies with finite degrees of freedom and for continuous elastic bodies with infinite degrees of freedom. This involves extending the direct method of Lyapunov so that it can be used to evaluate the stability of continuous elastic bodies. Special attention has also been paid to a dynamical treatment of the stability of these bodies, and the existence of nonconservative follower forces has been taken into account. For this second edition the author has fully revised and updated his material; in particular, the section on elastomechanics has been completely rewritten to include the major developments which have taken place in this area. Exercises for the reader have been added at the end of each chapter.
Stratified Radiative Transfer in a Fluid and Numerical Applications to Earth Science

New mathematical results are given for the Radiative Transfer equations alone and coupled with the temperature equation of a fluid: existence, uniqueness, a maximum principle and a convergent monotone iterative scheme. Numerical tests for Earth’s atmosphere and the heating of a pool by the Sun are included. KeywordsRadiative transfer, Temperature equation, Integral equation, Numerical analysis AMS3510, 35Q35, 35Q85, 80A21, 80M10
Emerging Biosensing Technologies towards Early Sepsis Diagnosis and Management

Sepsis is defined as a systemic inflammatory dysfunction strictly associated with infectious diseases, which represents an important health issue whose incidence is continuously increasing worldwide. Nowadays, sepsis is considered as one of the main causes of death that mainly affects critically ill patients in clinical settings, with a higher prevalence in low-income countries. Currently, sepsis management still represents an important challenge, since the use of traditional techniques for the diagnosis does not provide a rapid response, which is crucial for an effective infection management. Biosensing systems represent a valid alternative due to their characteristics such as low cost, portability, low response time, ease of use and suitability for point of care/need applications. This review provides an overview of the infectious agents associated with the development of sepsis and the host biomarkers suitable for diagnosis and prognosis. Special focus is given to the new emerging biosensing technologies using electrochemical and optical transduction techniques for sepsis diagnosis and management.
IsomiR-eQTL: A Cancer-Specific Expression Quantitative Trait Loci Database of miRNAs and Their Isoforms

The identification of expression quantitative trait loci (eQTL) is an important component in efforts to understand how genetic variants influence disease risk. MicroRNAs (miRNAs) are short noncoding RNA molecules capable of regulating the expression of several genes simultaneously. Recently, several novel isomers of miRNAs (isomiRs) that differ slightly in length and sequence composition compared to their canonical miRNAs have been reported. Here we present isomiR-eQTL, a user-friendly database designed to help researchers find single nucleotide polymorphisms (SNPs) that can impact miRNA (miR-eQTL) and isomiR expression (isomiR-eQTL) in 30 cancer types. The isomiR-eQTL includes a total of 152,671 miR-eQTLs and 2,390,805 isomiR-eQTLs at a false discovery rate (FDR) of 0.05. It also includes 65,733 miR-eQTLs overlapping known cancer-associated loci identified through genome-wide association studies (GWAS). To the best of our knowledge, this is the first study investigating the impact of SNPs on isomiR expression at the genome-wide level. This database may pave the way for researchers toward finding a model for personalised medicine in which miRNAs, isomiRs, and genotypes are utilised.
Selenium Nanoparticle-Enriched and Potential Probiotic, Lactiplantibacillus plantarum S14 Strain, a Diet Supplement Beneficial for Rainbow Trout

Simple Summary Potential probiotic bacteria for aquacultured species should be naturally occurring and non-pathogenic in the native habitat of the host, easy to culture, and able to grow in the intestine of the host. Se nanoparticles (Se0Nps) can be effectively used as a growth promoter, antioxidant, and immunostimulant agent in aquacultured species. Dietary supplementation with probiotics and Se0Nps contributes to the balance of the intestinal microbiota and probiotics have been proposed as an alternative to chemotherapeutants and antibiotics to prevent disease outbreaks, to mitigate the negative effects of stress and to strengthen the antioxidant capacity and the immune system of fish. Our results reported the isolation of a probiotic strain obtained from healthy rainbow trout. The strain was identified as Lactiplantibacillus plantarum species. This strain showed characteristics typically present in probiotics and, concurrently, the capacity to biosynthesize Se0Nps. The supplementation of the rainbow trout fish diet with LABS14-Se0Nps showed a positive effect on innate immune response parameters, oxidative status, well-being, and a better growth performance than the supplementation of the diet with the bacterium LABS14 alone. Therefore, we propose LABS14-Se0Nps as a promising alternative for the nutritional supplementation for rainbow trout or even other salmonids. Abstract Lactic acid bacteria (LAB), obtained from rainbow trout (Oncorhynchus mykiss) intestine, were cultured in MRS medium and probiotic candidates. Concurrently, producers of elemental selenium nanoparticles (Se0Nps) were selected. Probiotic candidates were subjected to morphological characterization and the following tests: antibacterial activity, antibiotic susceptibility, hemolytic activity, catalase, hydrophobicity, viability at low pH, and tolerance to bile salts. Two LAB strains (S4 and S14) satisfied the characteristics of potential probiotics, but only strain S14 reduced selenite to biosynthesize Se0Nps. S14 strain was identified, by 16S rDNA analysis, as Lactiplantibacillus plantarum. Electron microscopy showed Se0Nps on the surface of S14 cells. Rainbow trout diet was supplemented (108 CFU g−1 feed) with Se0Nps-enriched L. plantarum S14 (LABS14-Se0Nps) or L. plantarum S14 alone (LABS14) for 30 days. At days 0, 15, and 30, samples (blood, liver, and dorsal muscle) were obtained from both groups, plus controls lacking diet supplementation. Fish receiving LABS14-Se0Nps for 30 days improved respiratory burst and plasmatic lysozyme, (innate immune response) and glutathione peroxidase (GPX) (oxidative status) activities and productive parameters when compared to controls. The same parameters also improved when compared to fish receiving LABS14, but significant only for plasmatic and muscle GPX. Therefore, Se0Nps-enriched L. plantarum S14 may be a promising alternative for rainbow trout nutritional supplementation.
Analysis of the Temporal Evolution of Climate Variables Such as Air Temperature and Precipitation at a Local Level: Impacts on the Definition of Strategies for Adaptation to Climate Change

Climate change is a global phenomenon that can affect neighbouring territories and the communities residing there in different ways. This fact, which is associated with the specificities of each of the territories, leads to the need to implement adaptive measures to address the new reality imposed by climate change and to create more resilient territories and communities capable of facing this new paradigm. The more these measures are adjusted to the specificities of the territories and their communities, the more efficient they will be. Thus, it is essential to have a thorough understanding of the evolution of the climate on the local scale and the real needs of the resident populations. To identify these needs, a survey was conducted, and it was found that the dominant opinion of all respondents, comprising citizens residing in Portugal, was that climate change can affect geographically close territories in different ways. In the present work, the municipality of Guimarães, located in the north of Portugal, was used as a case study, where a comparative analysis was carried out to assess the period between the current climate, characterized by the period of 1971–2021, and the climate of 100 years ago, characterized by the decade of 1896–1905, to determine trends for the variables of air temperature and precipitation. It was found that the temperature in the winter months increased, with less uniformity in the distribution of precipitation throughout the year. These differences in the air temperature and precipitation, as variables, lead to the need to plan adaptive measures that can be implemented so that the territory and its communities become more resilient to climate change.
Specific Gene Duplication and Loss of Cytochrome P450 in Families 1-3 in Carnivora (Mammalia, Laurasiatheria)

Simple Summary In this study we investigated the specific duplication and loss events of cytochrome P450 (CYP) genes in families 1-3 in Carnivora. These genes have been recognized as essential detoxification enzymes, and, using genomic data, we demonstrated a synteny analysis of the CYP coding cluster and a phylogenetic analysis of these genes. We discovered the CYP2Cs and CYP3As expansion in omnivorous species such as the badger, the brown bear, the black bear, and the dog. Furthermore, phylogenetic analysis revealed the evolution of CYP2Cs and 3As in Carnivora. These findings are essential for the appropriate estimation of pharmacokinetics or toxicokinetic in wild carnivorans. Abstract Cytochrome P450s are among the most important xenobiotic metabolism enzymes that catalyze the metabolism of a wide range of chemicals. Through duplication and loss events, CYPs have created their original feature of detoxification in each mammal. We performed a comprehensive genomic analysis to reveal the evolutionary features of the main xenobiotic metabolizing family: the CYP1-3 families in Carnivora. We found specific gene expansion of CYP2Cs and CYP3As in omnivorous animals, such as the brown bear, the black bear, the dog, and the badger, revealing their daily phytochemical intake as providing the causes of their evolutionary adaptation. Further phylogenetic analysis of CYP2Cs revealed Carnivora CYP2Cs were divided into CYP2C21, 2C41, and 2C23 orthologs. Additionally, CYP3As phylogeny also revealed the 3As’ evolution was completely different to that of the Caniformia and Feliformia taxa. These studies provide us with fundamental genetic and evolutionary information on CYPs in Carnivora, which is essential for the appropriate interpretation and extrapolation of pharmacokinetics or toxicokinetic data from experimental mammals to wild Carnivora.
Boundary Smoothing for Scanned Mesh Segmentation based on Graph Cut

In this paper fuzzy boundary curves between two neighboring regions after mesh segmentation are globally rectiﬁed by a Graph Cut approach, in which we construct new energy functions with polygon face edge lengths, triangle normal and distortion tolerances between 3D points and the associated proxies. However, some boundary curves are still not straight since there are not straight lines around borders in the original scanned mesh models but its corresponding object curves are straight. In order to further straighten them, we will split some triangles by adding some points and edges based on triangle subdivision and optimize them based on Graph Cut method.
Hospital Surge Capacity Preparedness in Disasters and Emergencies: Protocol for a Systematic Review

Hospitals’ medical surge preparedness or surge capacity preparedness plays a significant role in reducing mortalities and in the treatment of severe injuries in disasters and emergencies. Though actions or activities for surge capacity preparedness of hospitals are discussed in several studies, they remain fragmented and need to be compiled. This systematic review will provide a comprehensive synthesis of evidence of actions or steps taken to strengthen hospitals’ medical surge preparedness in disasters and emergencies, which will eventually help develop surge capacity programs and relevant policies. All the studies published in peer-reviewed journals between 1 January 2016 and 30 July 2022, with full text available, will be included in this review. Seven electronic databases—PubMed, Scopus, MEDLINE, CINAHL, Embase, PsycINFO, and Ovid—will be searched. Two reviewers will independently screen the titles and abstracts using the eligibility criteria, review full-text articles, and extract data with the help of CADIMA software. A third reviewer will help resolve any discrepancies during the whole process. The extracted data will be narratively synthesized with the key characteristics and findings of the studies. The NIH quality assessment tools will be used to scale up the the quality of the retrieved quantitative studies. Moreover, the mixed methods appraisal tool (MMAT) and Noyes et al. guidelines will be used to assess the mixed methods studies and qualitative studies quality assessment, respectively.
Ground-state properties and high-pressure behavior of plutonium dioxide: Density functional theory calculations

Plutonium dioxide is of high technological importance in nuclear fuel cycle and is particularly crucial in long-term storage of Pu-based radioactive waste. Using first-principles density-functional theory, in this paper we systematically study the structural, electronic, mechanical, thermodynamic properties, and pressure induced structural transition of PuO$_{2}$. To properly describe the strong correlation in the Pu $5f$ electrons, the local density approximation$+U$ and the generalized gradient approximation$+U$ theoretical formalisms have been employed. We optimize the $U$ parameter in calculating the total energy, lattice parameters, and bulk modulus at the nonmagnetic, ferromagnetic, and antiferromagnetic configurations for both ground state fluorite structure and high pressure cotunnite structure. The best agreement with experiments is obtained by tuning the effective Hubbard parameter $U$ at around 4 eV within the LDA$+U$ approach. After carefully testing the validity of the ground state, we further investigate the bonding nature, elastic constants, various moduli, Debye temperature, hardness, ideal tensile strength, and phonon dispersion for fluorite PuO$_{2}$. Some thermodynamic properties, e.g., the Gibbs free energy, volume thermal expansion, and specific heat, are also calculated. As for cotunnite phase, besides the elastic constants, various moduli, and Debye temperature at 0 GPa, we have further presented our calculated electronic, structural, and magnetic properties for PuO$_{2}$ under pressure up to 280 GPa. A metallic transition at around 133 GPa and an isostructural transition in pressure range of 75-133 GPa are predicted.
Enhancing NO Uptake in Metal-Organic Frameworks via Linker Functionalization. A Multi-Scale Theoretical Study

In the present work, ab initio calculations and Monte Carlo simulations were combined to investigate the effect of linker functionalization on nitric oxide (NO)’s storage ability of metal-organic frameworks (MOFs). The binding energy (BE) of nitric oxide with a set of forty-two strategically selected, functionalized benzenes was investigated using Density Functional Theory calculations at the RI-DSD-BLYP/def2-TZVPP level of theory. It was found that most of the functional groups (FGs) increased the interaction strength compared to benzene. Phenyl hydrogen sulfate (–OSO3H) was the most promising among the set of ligands, with an enhancement of 150%. The organic linker of IRMOF-8 was modified with the three top-performing functional groups (–OSO3H, –OPO3H2, –SO3H). Their ability for NO adsorption was investigated using Grand Canonical Monte Carlo (GCMC) simulations at an ambient temperature and a wide pressure range. The results showed great enhancement in NO uptake constituting the above-mentioned FGs, suggesting them to be promising modification candidates in a plethora of porous materials.
Projection of Streamflow Change Using a Time‐Varying Budyko Framework in the Contiguous United States

Predicting future streamflow change is essential for water resources management and understanding the impacts of projected climate and land use changes on water availability. The Budyko framework is a useful and computationally efficient tool to model streamflow at larger spatial scales. This study predicts future streamflow changes in 889 watersheds in the contiguous United States based on projected climate and land use changes from 2040 to 2069. The temporal variability of surface water balance controls, represented by the Budyko ω parameter, was modeled using multiple linear regression, random forest (RF), and gradient boosting. Results show that RF is the optimal model and can explain >85% of the variance in most watersheds. Relative cumulative moisture surplus, forest coverage, crop land and urban land are the most important variables of the time‐varying ω in most watersheds. There are statistically significant increases in mean annual precipitation, potential evapotranspiration, and ω in 2040–2069, as compared to 1950–2005. This leads to a statistically significant decrease in the runoff ratio (Q/P). Streamflow is projected to decrease in the central, southwestern, and southeastern United States and increase in the northeast. These projections of water availability which are based on future climate and land use change scenarios can inform water resources management and adaptation strategies.
An outburst scenario for the X-ray spectral variability in 3C 111

We present a combined Suzaku and Swift BAT broad-band E=0.6–200 keV spectral analysis of three 3C 111 observations obtained in 2010. The data are well described with an absorbed power-law continuum and a weak (R ≃ 0.2) cold reflection component from distant material. We constrain the continuum cutoff at EC≃150– 200 keV, which is in accordance with X-ray Comptonization corona models and supports claims that the jet emission is only dominant at much higher energies. Fe XXVI Lyα emission and absorption lines are also present in the first and second observations, respectively. The modelling and interpretation of the emission line is complex and we explore three possibilities. If originating from ionized disc reflection, this should be emitted at rin > 50 rg or, in the lamp-post configuration, the illuminating source should be at a height of h > 30 rg over the black hole. Alternatively, the line could be modeled with a hot collisionally ionized plasma with temperature kT = 22.0 +6.1
Analysis of two non‐miscible electrically conducting micropolar fluid flow through an inclined porous channel: Influence of magnetic field

This work aims to analyse the flow of immiscible micropolar fluid through an inclined porous channel in presence of uniform magnetic field. The flow model have divided in two different porous regions and permeability of each porous region is taken different. The two immiscible electrically conducting micropolar fluids which have different densities and viscosities, take place through these two porous regions. The flow in an inclined porous channel is caused by a constant pressure gradient which acts on entrance section of flow domain. The flow of the micropolar fluids in the respective regions is governed by Brinkman's equation. The governing flow equations of the proposed model are solved analytically by reliable techniques and exact solution of flow field, flow rate and wall shear stress is evaluated by using well‐known boundary conditions. In this work, authors examined the influence of existing parameters such as permeability parameters, Hartmann number, gravitational parameter, viscosity ratio and so forth, which describes the physical significance of the presented model, on velocity profile, flow rate and wall shear stresses and these effect presented by graphs. The results are validated with the findings of past published article.