Miracle-dz/UniFAR-FTUs huggingface dataset:
Phosphorylation of the Septin Cdc3 in G1 by the Cdc28 Kinase Is Essential for Efficient Septin Ring Disassembly

The septins constitute a family of filament-forming proteins ubiquitous in eukaryotic species. We demonstrate here that the Saccharomyces cerevisiae septin, Cdc3, is a substrate of the cell cycle regulatory cyclin-dependent kinase (Cdk), Cdc28. Two serines near the C-terminus of Cdc3 are phosphorylated in a Cdc28-dependent manner. Analysis of a mutant allele that cannot be phosphorylated at these sites revealed an effect of Cdc28 phosphorylation of Cdc3 at the time of budding. Immunofluorescence analysis of wild-type and mutant Cdc3 indicated that prevention of phosphorylation at Cdc28-dependent sites impairs the disassembly of the old septin ring, which is inherited at mitosis but which usually disappears immediately prior to assembly of a new ring. Furthermore, immunofluorescence analysis of septin ring dynamics in a G1 cyclin (Cln) mutant suggests that G1 cyclin function is required for efficient ring disassembly. Thus, phosphorylation of Cdc3 by the Cdc28 kinase at the end of G1 may facilitate initiation of a new cell cycle by promoting disassembly of the obsolete septin ring from the previous cell cycle. Key Words G1, Cdc3, Septin Ring, Drosophila, Cytokinesis
Self-adaptive and sensitivity-aware QoS modeling for the cloud

Given the elasticity, dynamicity and on-demand nature of the cloud, cloud-based applications require dynamic models for Quality of Service (QoS), especially when the sensitivity of QoS tends to fluctuate at runtime. These models can be autonomically used by the cloud-based application to correctly self-adapt its QoS provision. We present a novel dynamic and self-adaptive sensitivity-aware QoS modeling approach, which is fine-grained and grounded on sound machine learning techniques. In particular, we combine symmetric uncertainty with two training techniques: Auto-Regressive Moving Average with eXogenous inputs model (ARMAX) and Artificial Neural Network (ANN) to reach two formulations of the model. We describe a middleware for implementing the approach. We experimentally evaluate the effectiveness of our models using the RUBiS benchmark and the FIFA 1998 workload trends. The results show that our modeling approach is effective and the resulting models produce better accuracy when compared with conventional models.
Fuzzy Cluster Analysis with Cluster Repulsion

We explore an approach to possibilistic fuzzy c -means clustering that avoids a severe drawback of the conventional approach, namely that the objective function is truly minimized only if all cluster centers are identical. Our approach is based on the idea that this undesired property can be avoided if we introduce a mutual repulsion of the clusters, so that they are forced away from each other. In our experiments we found that in this way we can combine the partitioning property of the probabilistic fuzzy c -means algorithm with the advantages of a possibilistic approach w.r. t. the interpretation of the membership degrees.
Eilenberg-MacLane spaces in homotopy type theory

Homotopy type theory is an extension of Martin-Löf type theory with principles inspired by category theory and homotopy theory. With these extensions, type theory can be used to construct proofs of homotopy-theoretic theorems, in a way that is very amenable to computer-checked proofs in proof assistants such as Coq and Agda. In this paper, we give a computer-checked construction of Eilenberg-MacLane spaces. For an abelian group G, an Eilenberg-MacLane space K(G,n) is a space (type) whose nth homotopy group is G, and whose homotopy groups are trivial otherwise. These spaces are a basic tool in algebraic topology; for example, they can be used to build spaces with specified homotopy groups, and to define the notion of cohomology with coefficients in G. Their construction in type theory is an illustrative example, which ties together many of the constructions and methods that have been used in homotopy type theory so far.
The effect of a prostaglandin I2 analogue (OP-41483) on energy metabolism in liver preservation and its relation to lipid peroxidative reperfusion injury in rats.

The effect of the stable prostacyclin (PGI2) analogue OP-41483 (OP) on liver preservation was investigated in the rat liver transplant model. In a 1-week survival study, 33 orthotopic liver transplants were performed using Wistar rats. In group A, untreated livers were stored with modified UW (mUW) solution at 4 degrees C. In group B, livers from OP-pretreated donors (2 micrograms/kg, i.v.) were stored with mUW solution containing OP (1 microgram/ml) at 4 degrees C. After 24 h storage, the donor grafts in each group were transplanted to untreated recipients. OP treatment (group B) significantly improved 1-week survival (62.5%, 10/16, P < 0.01 versus group A; 11.8%, 2/17). For the measurement of adenine nucleotides and lipid peroxidation (malondialdehyde, MDA) in liver tissue before preservation, after preservation, and 3 h after transplantation, 20 rat livers in groups A and B were studied. In both groups, the levels of adenosine triphosphate (ATP) declined 6 h after cold preservation, but this degradation of ATP was significantly halted at the level of adenosine monophosphate (AMP) in the OP-treated livers after 24 h of storage. However, OP treatment showed no significant difference in the degree of ATP recovery after transplantation. On the other hand, OP treatment resulted in suppression of the increase in MDA levels and histological amelioration of microcirculatory disturbance 3 h after transplantation. Our data suggested that the combined use of the stable PGI2 analog (OP-41483) and UW solution is beneficial in liver preservation. (ABSTRACT TRUNCATED AT 250 WORDS)
De impact van digitale campagnemiddelen op de personalisering van politieke partijen in Nederland (2010-2014)

Politicians have started to use social media more often. As such media induce personal campaigning, one might expect more personalization to follow. We explore what type of personalization social media stimulate, whether this is different for Twitter and Facebook and analyze the role of parties. We make use of quantitative and qualitative data about the Netherlands (2010-2014). We find that while theoretically the impact of social media may be big, in practice it is fairly limited: more presidentialization but not more individualization (though Twitter might increase the focus on other candidates slightly). The difference between theory and practice seems largely due to the parties. They adopt a very ambiguous stance: though they often stimulate candidates to use social media, they want to keep control nonetheless.
Requirement of Fas for the Development of Autoimmune Diabetes in Nonobese Diabetic Mice

Insulin-dependent diabetes mellitus (IDDM) is assumed to be a T cell–mediated autoimmune disease. To investigate the role of Fas-mediated cytotoxicity in pancreatic β cell destruction, we established nonobese diabetic (NOD)-lymphoproliferation (lpr)/lpr mice lacking Fas. Out of three genotypes, female NOD-+/+ and NOD-+/lpr developed spontaneous diabetes by the age of 10 mo with the incidence of 68 and 62%, respectively. In contrast, NOD-lpr/lpr did not develop diabetes or insulitis. To further explore the role of Fas, adoptive transfer experiments were performed. When splenocytes were transferred from diabetic NOD, male NOD-+/+ and NOD-+/lpr developed diabetes with the incidence of 89 and 83%, respectively, whereas NOD-lpr/lpr did not show glycosuria by 12 wk after transfer. Severe mononuclear cell infiltration was revealed in islets of NOD-+/+ and NOD-+/lpr, whereas islet morphology remained intact in NOD-lpr/lpr. These results suggest that Fas-mediated cytotoxicity is required to initiate β cell autoimmunity in NOD mice. Fas–Fas ligand system might be critical for autoimmune β cell destruction leading to IDDM.
Bioinformatics analysis on the differentiation of bone mesenchymal stem cells into osteoblasts and adipocytes

The present study aimed to screen several differentially expressed genes (DEGs) and differentially expressed microRNAs (miRNAs) for two types of mesenchymal stem cell (MSC) differentiation. Bone morphogenetic protein 6 (BMP-6) and dexamethasone were used to induce MSCs towards osteoblastic differentiation or adipocytic differentiation. The t-test in the Bioconductor bioinformatics software tool was used to screen DEGs and differentially expressed miRNAs in the two samples. Subsequent gene ontology (GO) and pathway analyses on the DEGs were performed using the GO and Kyoto Encyclopedia of Genes and Genomes databases, respectively; potential target genes for the screened miRNAs were predicted using the TargetScan database. In addition, an interaction network between the DEGs and miRNAs was constructed. Numerous DEGs and miRNAs were screened during osteoblastic and adipocytic differentiation of MSCs. Important pathways, such as glutathione metabolism, pathogenic Escherichia coli infection and Parkinson's disease, and GO terms, including cytoskeletal protein binding and phospholipase inhibitor activity, were enriched in the screened DEGs from MSCs undergoing osteogenic differentiation and adipocytic differentiation. miRNAs, including miRNA (miR)-382 and miR-203, and DEGs, including neuronal growth regulator 1 (NEGR1), phosphatidic acid phosphatase 2B (PPAP2B), platelet-derived growth factor receptor alpha (PDGFRA), interleukin 6 signal transducer (IL6ST) and sortilin 1 (SORT1), were demonstrated to be involved in osteoblastic differentiation. In addition, the downregulated miRNAs (including miR-495, miR-376a and miR-543), the upregulated miR-106a, the upregulated DEGs, including enabled homolog (ENAH), polypeptide N-acetylgalactosaminyltransferase 1 and acyl-CoA synthetase long-chain family member 1, and the downregulated repulsive guidance molecule family member B and semaphorin SEMA7A were demonstrated to be involved in adipocytic differentiation. The results of the present study suggested that miRNAs (miR-203 and miR-382) and DEGs (NEGR1, PPAP2B, PDGFRA, IL6ST and SORT1) may serve pivotal functions in the osteoblastic differentiation of MSCs, whereas miR-495, which is also involved in osteoblast differentiation and had four targets, including NEGR1, miR-376a, miR-543 and ENAH may have crucial roles in adipocytic differentiation of MSCs.
Toward a Career Anchor Structure: An Empirical Investigation of Engineers

Contrary to Schein’s theory of career anchors, which rests on the dominance of a single career anchor, the present study proposes an original career anchor structure that captures multiple dominant anchors. The analysis of data from a sample of 880 Quebec engineers supports this reconceptualization based on a circular model of career anchors. The new dynamics of career anchors shows that several anchors are complementary (e.g., creativity and challenge) while others are conflictual (e.g., challenge and security). In particular, the correlational analysis at the axial level indicates that the “self-enhancement” pole (managerial competence, identity) is negatively correlated with the “self-transcendence” (service/dedication to a cause, technical competence), whereas the pole “openness to change” (challenge, entrepreneurial creativity) is negatively correlated with the “conservation” pole (security, lifestyle). These findings can lead to more research in career management.
A New Design Technique for Column Compression Multipliers

In this paper, a new design technique for column-compression (CC) multipliers is presented. Constraints for column compression with full and half adders are analyzed and, under these constraints, considerable flexibility for implementation of the CC multiplier, including the allocation of adders, and choosing the length of the final fast adder, is exploited. Using the example of an 8/spl times/8 bit CC multiplier, we show that architectures obtained from this new design technique are more area efficient, and have shorter interconnections than the classical Dadda CC multiplier. We finally show that our new technique is also suitable for the design of twos complement multipliers. >
Interactive manipulation of sand on a TIN terrain model for virtual reality

This paper describes a new approach in modeling of sand surface. The terrain model is based on a triangulat ed irregular network while existing solutions have bee n based on a regular grid. Memory consumption is significantly reduced without a regular grid at the expense of more complicated algorithms. Our solutio n allows deforming terrain by a set of virtual tools and erosion simulation. All these simulations run in re al time. We want to use haptic devices with our application in the future.
Human daily activity recognition in robot-assisted living using multi-sensor fusion

In this paper, we propose a human daily activity recognition method by fusing the data from two wearable inertial sensors attached on one foot and the waist of the subject, respectively. We developed a multi-sensor fusion scheme for activity recognition. First, data from these two sensors are fused for coarse-grained classification in order to determine the type of the activity: zero displacement activity, transitional activity, and strong displacement activity. Second, a fine-grained classification module based on heuristic discrimination or hidden Markov models (HMMs) is applied to further distinguish the activities. We conducted experiments using a prototype wearable sensor system and the obtained results prove the effectiveness and accuracy of our algorithm.
The Law Relating to Corporate Groups

Corporate Groups Melvin Aron Eisenberg Corporate Groups - Management Dilemma Philip L Williams Grouped Therapies for Group Insolvencies James O'Donovan Corporate Parents and Tort Liability Robyn Carroll Corporate Groups - Problems for Outsiders Justice Andrew Rogers Problems for Directors within Corporate Groups R P Austin Outside Shareholders in Corporate Groups Michael Gillooly Problems for Insiders Paul Redmond Summing Up and a Search for Solutions Ralph P Simmonds References/ Index
In‐vivo occlusal caries prevention by pulsed CO2‐laser and fluoride varnish treatment—A clinical pilot study

High caries prevalence in occlusal pits and fissures warrants novel prevention methods. An 86% reduction in dental enamel smooth surface demineralization in‐vivo following short‐pulsed 9.6 µm‐CO2‐laser irradiation was recently reported. The objective of this study was to conduct a blinded 12‐month‐pilot clinical trial of occlusal pit and fissure caries inhibition using the same CO2‐laser irradiation conditions.
Introducing Personal Operating Spaces for Ubiquitous Computing Environments

a ubiquitous computing environment, a user will own and make use of many devices that vary in functionality and power. Furthermore, these devices will most likely be inter- connected around a space, such as a room in an intelligent building or a public space. Devices may join and leave the space through device detection and location management techniques in an ad-hoc seamless manner. For example, a user's home space may automatically detect and add a personal smart phone device, which could then be used to interact with other devices within the space. This study is concerned with the concept of a personal operating space: an entity formed for interaction between a user's mobile device and any environmental devices/services in the local space.
The effects of phonological regularity on writing of Hong Kong school-aged children

The study investigated effect of phonological regularity of phonetic compound characters on writing and its development. Students from grade 2, 4 and 6 with normal non-verbal IQ, Chinese reading ability and visual-spatial perceptual abilities were recruited. Writing to dictation on 16 characters, embedded in compound words, with phonological regularity, character frequency and stroke number controlled was implemented. Correct percentage was analyzed using 2-way ANOVA. Results showed regularity effect in grade 6. Error patterns suggested second graders processed at logographeme level while students from grade 4 onwards processed at radical level for writing. Sixth graders mastered regularity rule more proficiently than fourth graders as they had larger proportion of phonetic radical accessing error in regular than in irregular condition.
Apparent Position of Visual Targets during Real and Simulated Saccadic Eye Movements

It is now well established that briefly flashed single targets are mislocalized in space, not only during saccades but also before them. We show here by several techniques (including a vernier judgment that did not require absolute location in space) that errors appear up to 100 msec before saccades are made and are maximal just before they start. The size and even the sign of errors depend strongly on position in the visual field, the complete pattern of errors suggesting a compression of visual space around the initial fixation point and the target of the impending saccade. The compression was confirmed by displaying multiple rather than single targets and was found to be powerful enough to reduce or even to remove vernier offset for pairs of bars shown simultaneously and to create offsets for colinear bars separated in time by 75 msec. It also reduced the apparent number of parallel bars. When saccades were simulated by moving the display at saccadic speed, there were sometimes errors of location, but only for tasks requiring absolute judgment of position. The pattern of errors differed greatly from that during saccades and, in particular, showed no signs of compression. We can model our saccade results by assuming a shift in the point in space associated with eye position compression of eccentricity along the axis of saccades.
The Use and Perception of Electronic Cigarettes and Snus among the U.S. Population

Background E-cigarettes have generated controversy in the tobacco control field similar to that of Swedish snus, which came to the U.S. market six years earlier. Some argue that e-cigarettes have great potential to help smokers quit regular cigarettes while others contend they should be banned for lack of safety and efficacy data. This study examined population data from the U.S. Methods A U.S. population survey with a national probability sample (N=10,041) was conducted (February 24 to March 8, 2012, before any major paid advertisement of e-cigarettes appeared on television). Survey respondents were asked if they had heard about e-cigarettes, where they had heard about them, whether they had used e-cigarettes or snus, how often they used them, and why they used them. Responses were weighted to represent the entire U.S. population. Findings A high proportion, 75.4%, reported having heard about e-cigarettes. Television ranked as the number one source of information, followed by “in-person conversation” and “Internet. ” About 8.1% had tried e-cigarettes, and 1.4% were current users. These rates were twice those of snus (4.3% and 0.8%, respectively). Among current smokers, 32.2% had tried e-cigarettes, and 6.3% were current users. Over 80% of current e-cigarette users were non-daily users. Women were significantly more likely to have tried e-cigarettes than men. Those who had tried e-cigarettes were more likely than those who tried snus to report their products being safer than regular cigarettes (49.9% vs. 10.8%). Almost half (49.5%) of current smokers were susceptible to using e-cigarettes in the future. Conclusions That e-cigarettes have surpassed snus in adoption rate, even before any promotion by major tobacco companies, suggests that the former have tapped into smokers’ intuitive preference for potentially harm-reducing products, probably due to the product design. E-cigarette use is likely to increase in the next few years.
Association of HLA locus variant in Parkinson's disease

A variant (rs3129882) in the genome‐wide association study (GWAS)‐linked variant [in the human leukocyte antigen (HLA) gene region] has been reported to associate with an increased risk of Parkinson's disease (PD) in Caucasian population. Studies among Chinese are limited. To address this, we analysed rs3129882 in a total of 1312 subjects of Chinese ethnicity from independent Asian centers comprising of 675 controls and 637 PD cases. The rs3129882 variant was associated with a decreased risk in our ethnic Chinese PD patients. Logistic regression analysis taking into consideration variables of age, gender and race showed that allele A reduced the risk of PD via a dominant model [odds ratio (OR) = 0.77, 95% confidence interval (CI) = 0.62, 0.96, p = 0.018]. As HLA is a highly polymorphic region, it is possible that ethnic‐specific effect or environmental agents may modulate the effect of this GWAS‐linked locus in influencing the risk of PD.
Radial artery pulse wave measurement by photoplethysmograpy and compound pulse wave decomposition

Cardiovascular diseases are the world's largest killers, claiming 17.1 million lives a year (WHO 2009). Most countries face high and increasing rates of cardiovascular disease. High arterial stiffness is a symptom and increases the risk of cardiovascular diseases. Arteries stiffen normally as a consequence of age, but also because of arteriosclerosis. Age related stiffness occurs when the elastic fibers within the arterial walls begin to weaken due to age, but diseases as arteriosclerosis accelerate this process.
Current-Recycling Complex Filter for Bluetooth-Low-Energy Applications

This brief presents a flexible gm-C complex filter for Bluetooth-low-energy receivers. Each complex pole is realized sharing a bias current among transconductors, leading to an ultralow-power solution. The filter, which is designed in the 130-nm complimentary metal-oxide-semiconductor technology, has a power dissipation of only 42 μW from a 0.8-V supply voltage. With a center frequency and a passband of 2 and 1 MHz, respectively, the simulated filter provides a rejection of the adjacent channel of 34 dB and a spurious-free dynamic range of 52.7 dB.
Kinematic Modeling of a Small Mobile Robot with Multi-Locomotion Modes

The paper describes the kinematic modeling of a small wheel-track-legged mobile robot MOBIT which is targeted to applications in various hazardous environments to carry out military and civilian missions. The kinematic modeling for MOBIT has some individuality because of its multi-locomotion modes named wheeled, tracked, legged mode and obstacle negotiating mode. Different kinematics equations are derived based on its multi-locomotion modes respectively, and their features of kinematics in different modes are revealed. Particularly, the kinematic description of differential driven in wheeled mode, characteristics of slippage in tracked mode and posture definition in legged mode are presented mathematically. Unlike other robot operating on a flat surface, the proposed equations are solved to obtain the robot position and posture which can be used for autonomous motion control of robot operating in rough terrains
A novel run-time load balancing method for MapReduce

In recent years, many companies are embracing the Hadoop MapReduce system for large-data processing with completion time constrains. However, exiting Hadoop schedulers still suffer from the reducer load imbalancing problem. In this paper, we present a novel run-time load balancing method for MapReduce. Our approach predicts the workload of each reduce task at run-time, and assigns the reduce tasks to specified machines based on the estimated workload of reduce tasks dynamically. Therefore, our approach can achieve load balance among machines. The experimental results show that our approach achieves high accuracy while predicting the workload of reduce tasks, and improves the job completion time by up to 23.15%.