Miracle-dz/UniFAR-FTUs huggingface dataset:
FPGA-Based Intelligent-Complementary Sliding-Mode Control for PMLSM Servo-Drive System

A field-programmable gate array (FPGA)-based intelligent-complementary sliding-mode control (ICSMC) is proposed in this paper to control the mover of a permanent magnet linear synchronous motor (PMLSM) servo-drive system to track periodic-reference trajectories. First, the dynamics of the field-oriented control PMLSM servo drive with a lumped uncertainty, which contains parameter variations, external disturbances, and nonlinear-friction force, is derived. Then, to achieve the required high-control performance, the ICSMC is developed. In this approach, a radial-basis function-network (RBFN) estimator with accurate approximation capability is employed to estimate the lumped uncertainty directly. Moreover, the adaptive-learning algorithms for the online training of the RBFN are derived using the Lyapunov theorem to guarantee the closed-loop stability. Furthermore, the FPGA chip is adopted to implement the developed control and online learning algorithms for possible low-cost and high-performance industrial applications using PMLSM. Finally, some experimental results are illustrated to show the validity of the proposed control approach.
Two-step activation of meiosis by the mat1 locus in Schizosaccharomyces pombe

The mat1 locus is a key regulator of both conjugation and meiosis in the fission yeast Schizosaccharomyces pombe. Two alternative DNA segments of this locus, mat1-P and mat1-M, specify the haploid cell types (Plus and Minus). Each segment includes two genes: mat1-P includes mat1-Pc and mat1-Pm, while mat1-M includes mat1-Mc and mat1-Mm. The mat1-Pc and mat1-Mc genes are responsible for establishing the pheromone communication system that mediates conjugation between P and M cells, while all four mat1 genes are required for meiosis in diploid P/M cells. Our understanding of the initiation of meiosis is based largely on indirect observations, and a more precise investigation of these events was required to define the interaction between the mat1 genes. Here we resolve this issue using synthetic pheromones and P/M strains with mutations in either mat1-Pc or mat1-Mc. Our results suggest a model in which the mat1 locus plays two roles in controlling meiosis. In the first instance, the mat1-Pc and mat1-Mc functions are required to produce the mating pheromones and receptors that allow the generation of a pheromone signal. This signal is required to induce the expression of mat1-Pm and mat1-Mm. This appears to be the major pheromone-dependent step in controlling meiosis since ectopic expression of these genes allows meiosis in the absence of mat1-Pc and mat1-Mc. The mat1-Pm and mat1-Mm products complete the initiation of meiosis by activating transcription of the mei3 gene.
Building Firewalls or Floodgates? Constitutional Design for the European Union

This article draws on the experience of comparative federalism to assess the efficacy of institutional safeguards against authority migration contained in the draft Constitutional Treaty. It evaluates the impact of the methods of authority allocation, judicial safeguards and ex ante structural safeguards in five federations. It argues that the approach opted for in the Treaty would strengthen structural safeguards through reforming the subsidiarity procedure, but the proposed method of power allocation provides opportunities for authority migration that the courts would be unlikely to remedy. Future reform efforts should bear this in mind.
Managing ethics in the tourism supply chain: The case of Chinese travel to Australia

The purpose of this paper is to provide clues to industry and academia on how best to approach the challenge of managing ethics in the tourism supply chain. To achieve this objective, the paper provides a case study of how the Australian Government has responded to concerns about unethical practices in the tourism supply chain from China to Australia. A series of best practice recommendations are provided following a review of demand- and supply-side processes.
An Adaptive Splitting and Transmission Control Method for Rendering Point Model on Mobile Devices

The physical characteristics of current mobile devices impose significant constraints on the processing of 3D graphics. The remote rendering framework is considered a better choice in this regard. However, limited battery life is a critical constraint when using this approach. Earlier methods based on this framework suffered from high transmission frequency. We present a software solution to this problem with a key element, an Adaptive Splitting and Error Handling Mechanism that indirectly reserves the electricity in mobile devices by reducing the transmission frequency. To achieve this goal, a geometric relation is maintained that tightly couples several consecutive Levels of Detail (LOD). Adaptive Splitting can then approximate the LOD from a much coarser split base under the guidance of the relation. Data transmission between the server and mobile device occurs only when out-ranged LOD is about to be displayed. Our remote rendering architecture, based on the above approach, trades splitting process for transmission, thereby alleviating the problem of frequent data transmission.
Antigen‐Specific Therapy Promotes Repair of Myelin and Axonal Damage in Established EAE

Inflammation results in CNS damage in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), an animal model of MS. It is uncertain how much repair of injured myelin and axons can occur following highly selective anti‐inflammatory therapy in EAE and MS. In this study, SJL/J mice with established EAE were treated successfully with an antigen‐specific recombinant T cell receptor ligand (RTL), RTL401, a mouse I‐As/PLP‐139–151 construct, after the peak of EAE. To define the mechanisms by which late application of RTL401 inhibits EAE, we evaluated mice at different time points to assess the levels of neuroinflammation and myelin and axon damage in their spinal cords. Our results showed that RTL401 administered after the peak of acute EAE induced a marked reduction in inflammation in the CNS, associated with a significant reduction of demyelination, axonal loss and ongoing damage. Electron microscopy showed that RTL‐treated mice had reduced pathology compared with mice treated with vehicle and mice at the peak of disease, as demonstrated by a decrease in continued degeneration, increase in remyelinating axons and the presence of an increased number of small, presumably regenerative axonal sprouts. These findings indicate that RTL therapy targeting encephalitogenic T cells may promote CNS neuroregenerative processes.
Impacts of macroeconomic policies on the Mexican output

This paper examines the potential effects of macroeconomic policies, stock market performance, exchange rate fluctuations, and other related variables on real GDP in Mexico. Extending the works by Arango and Nadiri (1981) and Bahmani‐Oskooee and Ng (2002), and applying comparative‐static analysis, possible effects of a change in the exchange rate or government debt on the equilibrium output are examined. All the variables have unit roots and are stationary in first difference. There is a long‐run stable relationship between real GDP and the right‐hand‐side variables. The GARCH(p,q) (Engle 2001) model is applied to estimate regression parameters. Real GDP is positively associated with real M2, government deficit spending, stock prices, U.S. output, and world oil prices, and negatively affected by the government debt ratio, peso depreciation, and the expected inflation rate. Therefore, fiscal policy to incur more debt needs to be pursued with caution, and both net exports and money demand need to be considered in studying the impact of exchange rate fluctuations on output.
Screening for Colorectal Cancer.

IMPORTANCE Colorectal cancer is the third leading cause of cancer death for both men and women, with an estimated 52 980 persons in the US projected to die of colorectal cancer in 2021. Colorectal cancer is most frequently diagnosed among persons aged 65 to 74 years. It is estimated that 10.5% of new colorectal cancer cases occur in persons younger than 50 years. Incidence of colorectal cancer (specifically adenocarcinoma) in adults aged 40 to 49 years has increased by almost 15% from 2000-2002 to 2014-2016. In 2016, 26% of eligible adults in the US had never been screened for colorectal cancer and in 2018, 31% were not up to date with screening.
A Comparative Study of Political Newspaper Advertising in the United States and Japan

This study examines the contents of political advertising between the U.S. and Japan. The population of this study was defined as all political ads appearing in major daily newspapers during the 1963–1996 presidential election campaigns in the U.S. and the House of Representatives' election campaigns in Japan. In the case of U.S., five major dailies were selected for the present study: the Atlanta Constitution, the Chicago Tribune, the LA Times, the New York Times, and the Washington Post. In the case of Japan, it has four major national dailies: the Asahi Shimbun, the Mainichi Shimbun, the Yomiuri Shimbun, and the Nihonkeizai Shimbun. A total of 396 newspaper ads were analyzed in this study. Results of this study showed that there were differences of types and valences of political advertising between the U.S. and Japan.
Social class and leisure during recent recessions in Britain

This paper assembles time series data on leisure participation rates and expenditure to assess the impact of recessions in the UK during and since the 1980s, and the widening of social class disparities in income since then. It shows that in both cases there have been clear impacts on leisure spending, but to a lesser and variable extent on participation in leisure activities. The conclusions that are drawn highlight weaknesses in the data currently available to leisure scholars, specifically the limited time series and the absence of a limited number of key indicators of leisure use. An important feature of leisure itself is also highlighted: specifically the stability of participation rates over extended periods of time. The failure of leisure scholars to address this feature of their subject matter is attributed to its invisibility before time series are constructed and examined.
Variation in the Three-Dimensional Histomorphometry of the Normal Human Optic Nerve Head With Age and Race: Lamina Cribrosa and Peripapillary Scleral Thickness and Position

Purpose This study quantified the thickness and depth of the lamina cribrosa (LC) and peripapillary scleral thickness in high-resolution three-dimensional (3D) fluorescent reconstructions of the optic nerve head (ONH) in eyes from donors of African (AD) and European descent (ED). Methods A total of 64 eyes (45 ED, 19 AD) from 51 normal donors were obtained within 6 hours of death and fixed at 10 mm Hg of pressure. The optic nerve head was trephined from the globe and digitally reconstructed at 1.5 × 1.5 × 1.5 μm voxel resolution with an automated episcopic fluorescence technique. The load-bearing ONH connective tissue surfaces were manually delineated in 3D using custom software. Results The lamina cribrosa and peripapillary sclera were significantly thinner in AD eyes adjusting for age and sex (LC was 24 ± 11 μm thinner; P = 0.0350; scleral was 56 ± 22 μm thinner; P = 0.0097). The lamina cribrosa was significantly thinner in females (23 ± 11 μm thinner; P = 0.0425). Age was not significantly associated with any morphologic parameter in the ED group. However, increasing age was associated with an increase in scleral thickness (1.3 μm/year, P = 0.0499) and an increase in LC depth (2.3 μm/year, P = 0.0035) in the AD group. The sclera was thickest in the superior and temporal regions while the LC was thinnest superiorly. Conclusions Substantial sectorial and racial differences in LC and scleral morphology were observed, as well as increasing LC depth and scleral thickness with age in the AD group. Results suggest greater age-related remodeling of the load-bearing ONH connective tissues in eyes from AD individuals that could explain, in part, the greater predilection to glaucomatous injury seen in aged AD populations.
Heat tolerance in two tropically adapted Bos taurus breeds, Senepol and Romosinuano, compared with Brahman, Angus, and Hereford cattle in Florida.

Two trials were conducted with heifers to determine heat tolerance among temperate Bos taurus (Angus, Hereford), Bos indicus (Brahman), tropical Bos taurus (Senepol, Romosinuano), and the reciprocal crosses of Hereford and Senepol. Differences among breeds in temperament score, circulating concentrations of cortisol, and blood packed cell volume were also investigated. Trial 1 used 43 Angus, 28 Brahman, 12 Hereford, 23 Romosinuano, 16 Senepol, 5 Hereford x Senepol (H x S), and 5 Senepol x Hereford (S x H) heifers. Trial 2 used 36 Angus, 31 Brahman, 9 Hereford, 14 Senepol, 19 H x S, and 10 S x H heifers. On the hottest summer date in Trial 1, rectal temperature of Angus was greater (P < .001) than that of Brahman, Senepol, or Romosinuano. Rectal temperature and plasma cortisol were significantly less in Senepol than in Brahman, suggesting that the differences in rectal temperature between these breeds may be due to differences in stress response possibly related to differences in temperament. Reciprocal crosses of Hereford and Senepol had rectal temperatures nearly as low as that of Senepol and displayed substantial heterosis (-9.4%, P < .05) in log10 rectal temperature on the hottest summer date. On both the hottest and coolest dates in Trial 1, Angus heifers had significantly faster respiration rates than Brahman, Romosinuano, or Senepol heifers, and Brahman had significantly slower respiration rates than Romosinuano or Senepol. On the hottest summer date in Trial 2, rectal temperature in Angus heifers was greater (P < .001) than in Brahman or Senepol had rectal temperatures similar to that of Senepol, or heterosis for log10 rectal temperature was similar to that in Trial 1 (-9.8%, P < .05). Considering rank order among breeds, Brahman always had the slowest respiration rate and greatest packed cell volume. Brahman had significantly greater temperament scores and plasma cortisol concentrations than Angus or Senepol, except that plasma cortisol was not different between Brahman and Senepol on the hottest summer date. On this date, rectal temperature did not differ between Brahman and Senepol, which supports the hypothesis that there is a relationship between response to stress and rectal temperature that helps explain differences in rectal temperature between Brahman and Senepol. The results of these trials demonstrate heat tolerance of the Senepol and Romosinuano, two Bos taurus breeds. Furthermore, the results suggest a substantial level of dominance of the Senepol's ability to maintain constant body temperature in a hot environment as measured by rectal temperature in crosses with a non-adapted breed.
An analysis of human capital on the Brazilian States income level: MRW versus Mincer

Human capital, productivity and physical capital are considered the main factors in the economies’ GDP per capita determination. According to the neoclassical approach, human capital accumulation explains about a third of the variation in per capita income across countries. However, there is no consensus on the ways in which human capital influences GDP per capita. The present study’s goal is to compare two production functions functional forms for the Brazilian States: the one developed by SOLOW (1956) and the one developed by MINCER (1974). The marginal return of education also has been estimated and we have analyzed the relevance of human capital on GDP per capita determination through a variety of estimation methods, for the 1980-2002 period. The empirical results rejected the neoclassical specification with human capital in favor of the mincerian’s specification. The estimated marginal return of education is 15% and the empirical findings support the theory that states that human capital is one of the main factors affecting income level.
Scaling Up Local Government Initiatives Toward Ecosystem-Based Fisheries Management in Southeast Cebu Island, Philippines

The Philippines adopts a highly decentralized approach to coastal management. Each municipal authority exercises management powers and responsibilities over their 15-km municipal waters. Nevertheless, in some areas like Southeast Cebu in Central Philippines, coastal resource management practices of a single municipality have been working toward scaling up the geographic scope to achieve the desired results of ecosystem-based management by expanding from a single municipality to a much broader collaboration at the intermunicipal scale. Such cooperative undertakings focus on activities that jointly address the major resource threats in each of the municipal jurisdictions, such as degradation of key coastal habitats, overfishing, and dwindling fish stocks. This article presents the management strategies, outcomes, and lessons of an intermunicipal collaboration that is starting to work and shows that local governance systems can be expanded to address the conservation needs of a broader ecosystem and scale.
New aerobactin-mediated iron uptake system in a septicemia-causing strain of Enterobacter cloacae

Unlike the great majority of the aerobactin-producing enteric bacteria documented in the literature, Enterobacter cloacae EK33, isolated from a case of human neonatal meningitis, did not show any homology at the DNA level with the prototype aerobactin system encoded by the ColV-K30 plasmid. However, both the nuclear magnetic resonance spectrum and fast-atom bombardment mass spectrometry of the siderophore purified from EK33 confirmed its identity with aerobactin. Bioassay screening of a gene library of total DNA of EK33 led to the isolation of several aerobactin-positive clones. Under conditions of iron limitation, these clones expressed in Escherichia coli a protein of 72 kilodaltons that reacted with antiserum raised against the pColV-K30 74-kilodalton aerobactin receptor, while the original E. cloacae strain synthesized an 85-kilodalton protein which also cross-reacted with the antiserum. Restriction endonuclease analysis of the cloned DNA confirmed the structural differences between the two aerobactin genetic systems.
Portfolio Performance Evaluation with Loss Aversion

In this paper we consider a loss averse investor equipped with a specific, but still quite general, utility function motivated by behavioral finance. We show that under some concrete assumptions about the form of this utility one can derive closed-form solutions for the investor's portfolio performance measure. We investigate the effects of loss aversion and demonstrate its important role in performance measurement. The framework presented in this paper also provides a sound theoretical foundation for all known performance measures based on partial moments of distribution.
The Na+:Cl– Cotransporter Is Activated and Phosphorylated at the Amino-terminal Domain upon Intracellular Chloride Depletion*

The renal Na+:Cl– cotransporter rNCC is mutated in human disease, is the therapeutic target of thiazide-type diuretics, and is clearly involved in arterial blood pressure regulation. rNCC belongs to an electroneutral cation-coupled chloride cotransporter family (SLC12A) that has two major branches with inverse physiological functions and regulation: sodium-driven cotransporters (NCC and NKCC1/2) that mediate cellular Cl– influx are activated by phosphorylation, whereas potassium-driven cotransporters (KCCs) that mediate cellular Cl– efflux are activated by dephosphorylation. A cluster of three threonine residues at the amino-terminal domain has been implicated in the regulation of NKCC1/2 by intracellular chloride, cell volume, vasopressin, and WNK/STE-20 kinases. Nothing is known, however, about rNCC regulatory mechanisms. By using rNCC heterologous expression in Xenopus laevis oocytes, here we show that two independent intracellular chloride-depleting strategies increased rNCC activity by 3-fold. The effect of both strategies was synergistic and dose-dependent. Confocal microscopy of enhanced green fluorescent protein-tagged rNCC showed no changes in rNCC cell surface expression, whereas immunoblot analysis, using the R5-anti-NKCC1-phosphoantibody, revealed increased phosphorylation of rNCC amino-terminal domain threonine residues Thr53 and Thr58. Elimination of these threonines together with serine residue Ser71 completely prevented rNCC response to intracellular chloride depletion. We conclude that rNCC is activated by a mechanism that involves amino-terminal domain phosphorylation.
Qualitative Evaluation of Divergent Thinking in Patients with Schizophrenia

Patients with schizophrenia show deficits across a broad spectrum of neurocognitive domains. In particular, deficits in verbal fluency are common. Verbal fluency tests are neuropsychological tests that assess frontal lobe function or executive function but also assess divergent thinking. However, few studies have considered the impairment of verbal fluency from the viewpoint of divergent thinking. To consider the structure of divergent thinking, not only verbal assessments but also non-verbal assessments are indispensable. We administered several fluency tests, the idea fluency test, the design fluency test, and word (letter and category) fluency tests to 26 patients with schizophrenia and 26 healthy control subjects to evaluate divergent thinking in both groups and assessed their responses qualitatively. An acceptable minimal level of intelligence was maintained in the patient group. Although attention and executive functioning were relatively preserved in the subjects with schizophrenia, they demonstrated significant deficits in divergent thinking and had particular difficulty in producing ideas and designs requiring concept flexibility, a conversion of viewpoint, originality, or novelty. Research on deficits in divergent thinking in patients with schizophrenia may contribute to the development of cognitive and behavioral rehabilitation programs.
Leadership Factors in Organizational Change Process: Observations from the Perspective of Management Accounting

Worldwide efforts to transform the public sector under the theme of “New Public Management” have been concerned with the issues of organizational change management. The change in the Accounting sector is one of the pillars of such efforts. This paper promotes the importance of leadership roles within the accounting change process by studying them within the context of a corporatized public sector entity. It offers a longitudinal analysis (1998‐2005) through the framework of “levers of control”. Leadership roles within the accounting scenario are compared with leadership roles within the engineering scenario to demonstrate the importance of accounting in mediating leadership roles, and in the end, promote the organization’s operational and financial performance. Through the framework of levers of control, this paper examines the different approaches and styles of an organizational leader in aligning beliefs systems among the workers, and creating management control systems through the mobilization of accounting calculative and constitutive power. This paper argues the importance of studying the characteristics of good leadership with in the organizational transformation process, particularly within the change management accounting practice that could lead to better organizational performance of the organization.