Miracle-dz/UniFAR-FTUs huggingface dataset:
A phase-shift PWM-controlled ZVS boost full-bridge AC-AC converter for metal-surface high-frequency induction heating applications

This paper presents a new single-stage utility frequency ac (UFAC)-high frequency ac(HFAC) resonant power converter for high frequency induction heating(IH) applications. The newly-proposed ac-ac converter features a boost converter and full-bridge HF resonant inverter integrated circuit (Boost-Full-Bridge BFB) with a source voltage sensorless control scheme. The experimental results of a 3.0kW–40kHz prototype are demonstrated on zero voltage soft switching (ZVS) operations and steady-state characteristics based on the phase shift pulse-width-modulation (PS-PWM) power regulation, then the validity of the proposed ac-ac converter is revealed from a practical point of view.
Charge Scattering and Mobility in Atomically Thin Semiconductors

The electron transport properties of atomically thin semiconductors such as MoS2 have attracted significant recent scrutiny and controversy. In this work, the scattering mechanisms responsible for limiting the mobility of single layer semiconductors are evaluated. The roles of individual scattering rates are tracked as the 2D electron gas density is varied over orders of magnitude at various temperatures. From a comparative study of the individual scattering mechanisms, we conclude that all current reported values of mobilities in atomically thin transition-metal dichalcogenide semiconductors are limited by ionized impurity scattering. When the charged impurity densities are reduced, remote optical phonon scattering will determine the ceiling of the highest mobilities attainable in these ultrathin materials at room temperature. The intrinsic mobilities will be accessible only in clean suspended layers, as is also the case for graphene. Based on the study, we identify the best choices for surrounding dielectrics that will help attain the highest mobilities.
Mining Product Reviews in Web Forums

Internet has brought a major drift in user community. Apart from its well-known usage, it also promotes social networking. Research on such social networking has advanced significantly in recent years which have been highly influenced by the online social websites. People perceive the web as a social medium that allows larger interaction among people, sharing of knowledge, or experiences. Internet or social web forums act as an agent to reproduce some general information that would benefit the users. A product review by the user is a more accurate representation of its real-world performance and web-forums are generally used to post such reviews. Though commercial review websites allow users to express their opinions in whatever way they feel, the number of reviews that a product receives could be very high. Hence, opinion mining techniques can be used to analyze the user-reviews, classify the content as positive or negative, and thereby find out how the product fares. This paper focuses its attention on providing a recommendation to the products available on the web by analyzing the context to score the sentences for each review by identifying the opinion and feature words using a novel algorithm.
Proceedings of the 1 st Workshop on Semantic Personalized Information Management SPIM 2010 Workshop Organizers

The Semantic Web dream of a real world-wide graph of interconnected resources is – slowly but steadily – becoming a concrete reality. Still, the whole range of models and technologies which will change forever the way we interact with the web, seems to be missing from every-day technologies available on our personal computers. Ontologies, annotation facilities and semantic querying could (and should) bring new life to Personal Information Management, supporting users in contrasting the ever-growing information overload they are facing in these years, overwhelmed by plethora of communication channels and media. In this paper we present our attempt in bringing the Semantic Web Knowledge Management paradigm at the availability of diverse personal desktop tools (Web Browser, Mail clients, Agenda etc.), by evolving Web Browser Semantic extension Semantic Turkey to an extensible framework providing RDF data access at different levels: java access through OSGi extensions, HTTP access or dedicated JavaScript API for the whole range of tools from the open source suite of Mozilla applications
How to Ask for Permission

Application platforms provide applications with access to hardware (e.g., GPS and cameras) and personal data. Modern platforms use permission systems to protect access to these resources. The nature of these permission systems vary widely across platforms. Some platforms obtain user consent as part of installation, while others display runtime consent dialogs. We propose a set of guidelines to aid platform designers in determining the most appropriate permission-granting mechanism for a given permission. We apply our proposal to a smart-phone platform. A preliminary evaluation indicates that our model will reduce the number of warnings presented to users, thereby reducing habituation effects.
Shedding New Light on the Platelet Storage Lesion.

In this issue of ATVB , Chen et al1 report that a monoclonal antibody whose epitope includes the ADAM17 cleavage site in human platelet glycoprotein Ibα (GPIbα) inhibits GPIbα shedding during platelet storage under blood banking conditions and improves the recovery and survival of platelets in murine platelet transfusion models. See accompanying article on page 1821 The lifespan of circulating endogenous platelets is determined by a combination of random platelet removal and a nonrandom aging mechanism after which senescent platelets are removed by the reticuloendothelial system. At least a portion of platelet senescence is regulated by an intrinsic apoptotic pathway that acts as an internal timer.2,3 Platelets contain members of the antiapoptotic Bcl-2 family, such as Bcl-xL, as well as the proapoptotic proteins Bax and Bak.2,4 The half-life of Bcl-xL in platelets is shorter than that of Bak.2,5 Thus, it is likely that as the effect of Bcl-xL declines, a point is reached at which Bak is able to cause platelet apoptosis.3 How apoptosis causes platelet clearance is unknown. Apoptosis causes phosphotidylserine exposure on cell surfaces, a signal for the phagocytosis of apoptotic cells,6 but it remains to be …
Diversity techniques for concurrent error detection

Concurrent error detection (CED) techniques are widely used to ensure data integrity in digital systems. Data integrity guarantees that the system outputs are either correct or an error is indicated when incorrect outputs are produced. This dissertation presents the results of theoretical and simulation studies of various CED techniques. The CED schemes studied are based on diverse duplication, simple duplication of identical implementations, and error-detection techniques like parity checking. The study aimed at [1] a quantitative comparison of the effectiveness different CED schemes, and (2) developing design techniques for efficient concurrent error detection.
Diffusion tensor imaging studies of mild traumatic brain injury: a meta-analysis

Objectives To assess the possibility that diffusion tensor imaging (DTI) can detect white matter damage in mild traumatic brain injury (mTBI) patients via systematic review and meta-analysis. Methods DTI studies that compared mTBI patients and controls were searched using MEDLINE, Web of Science, and EMBASE, (1980 through April 2012). Results A comprehensive literature search identified 28 DTI studies, of which 13 independent DTI studies of mTBI patients were eligible for the meta-analysis. Random effect model demonstrated significant fractional anisotropy (FA) reduction in the corpus callosum (CC) (p=0.023, 95% CIs −0.466 to −0.035, 280 mTBIs and 244 controls) with no publication bias and minimum heterogeneity, and a significant increase in mean diffusivity (MD) (p=0.015, 95% CIs 0.062 to 0.581, 154 mTBIs and 100 controls). Meta-analyses of the subregions of the CC demonstrated in the splenium FA was significantly reduced (p=0.025, 95% CIs −0.689 to −0.046) and MD was significantly increased (p=0.013, 95% CIs 0.113 to 0.950). FA was marginally reduced in the midbody (p=0.099, 95% CIs −0.404 to 0.034), and no significant change in FA (p=0.421, 95% CIs −0.537 to 0.224) and MD (p=0.264, 95% CIs −0.120 to 0.438) in the genu of the CC. Conclusions Our meta-analysis revealed the posterior part of the CC was more vulnerable to mTBI compared with the anterior part, and suggested the potential utility of DTI to detect white matter damage in the CC of mTBI patients.
Phenotypic and Molecular Characterization of Tetracycline- and Erythromycin-Resistant Strains of Streptococcus pneumoniae

ABSTRACT Sixty-five clinical isolates of Streptococcus pneumoniae, all collected in Italy between 1999 and 2002 and resistant to both tetracycline (MIC, ≥8 μg/ml) and erythromycin (MIC, ≥1 μg/ml), were investigated. Of these strains, 11% were penicillin resistant and 23% were penicillin intermediate. With the use of the erythromycin-clindamycin-rokitamycin triple-disk test, 14 strains were assigned to the constitutive (cMLS) phenotype of macrolide resistance, 44 were assigned to the partially inducible (iMcLS) phenotype, 1 was assigned to the inducible (iMLS) phenotype, and 6 were assigned to the efflux-mediated (M) phenotype. In PCR assays, 64 of the 65 strains were positive for the tetracycline resistance gene tet(M), the exception being the one M isolate susceptible to kanamycin, whereas tet(K), tet(L), and tet(O) were never found. All cMLS, iMcLS, and iMLS isolates had the erythromycin resistance gene erm(B), and all M phenotype isolates had the mef(A) or mef(E) gene. No isolate had the erm(A) gene. The int-Tn gene, encoding the integrase of the Tn916-Tn1545 family of conjugative transposons, was detected in 62 of the 65 test strains. Typing assays showed the strains to be to a great extent unrelated. Of 16 different serotypes detected, the most numerous were 23F (n = 13), 19A (n = 10), 19F (n = 9), 6B (n = 8), and 14 (n = 6). Of 49 different pulsed-field gel electrophoresis types identified, the majority (n = 39) were represented by a single isolate, while the most numerous type included five isolates. By high-resolution restriction analysis of PCR amplicons with four endonucleases, the tet(M) loci from the 64 tet(M)-positive pneumococci were classified into seven distinct restriction types. Overall, a Tn1545-like transposon could reasonably account for tetracycline and erythromycin resistance in the vast majority of the pneumococci of cMLS, iMcLS, and iMLS phenotypes, whereas a Tn916-like transposon could account for tetracycline resistance in most M phenotype strains.
Postictal coughing and noserubbing coexist in temporal lobe epilepsy

Postictal coughing (PIC) has been described as a clinical localizing sign more common in temporal than extratemporal epilepsy.1,2⇓ Postictal noserubbing (PIN) is another clinical sign indicative of temporal lobe seizure onset.3-6⇓⇓⇓ PIN is thought to occur in response to increased nasal secretions caused by ictal activation of the central autonomic pathways.3,4,6⇓⇓ Because PIC could also be a reaction to increased respiratory secretions,3 this study sought to determine whether PIC and PIN co-occurred in the same patients. If so, it would define a subset of patients with temporal lobe epilepsy whose seizures preferentially induce secretions throughout the nasotracheobronchial tree. As part of a larger prospective study analyzing the electroclinical features of PIN,6 episodes of PIC were documented in a group of 75 consecutive patients with temporal lobe epilepsy investigated in an epilepsy monitoring unit between April 1997 and April 2000. Coughing that occurred simultaneously with electrographic ictal offset or within a few seconds (1 to 3) of …
A Borda count approach to combine subjective and objective based MIS journal rankings

Purpose – Ranking relevant journals is very critical for researchers to choose their publication outlets, which can affect their research performance. In the management information systems (MIS) subject, many related studies conducted surveys as the subjective method for identifying MIS journal rankings. However, very few consider other objective methods, such as journals’ impact factors and h-indexes. The paper aims to discuss these issues. Design/methodology/approach – In this paper, top 50 ranked journals identified by researchers’ perceptions are examined in terms of the correlation to the rankings by their impact factors and h-indexes. Moreover, a hybrid method to combine these different rankings based on Borda count is used to produce new MIS journal rankings. Findings – The results show that there are low correlations between the subjective and objective based MIS journal rankings. In addition, the new MIS journal rankings by the Borda count approach can also be considered for future researches. Or.
VIBRATION MODULUS OF NORMALLY CONSOLIDATED CLAY

The resonant-column technique was used to measure the vibration shear modulus of a normally consolidated kaolinite under various anisotropic states of stress. The effects of the deviatoric and isotropic components of stress, void ratio, and other secondary effects are studied. Data from these tests along with other previously published test results for other clays with different structures lead to the following conclusions: (1) The vibration shear modulus is independent of the deviatoric component of ambient stress (octahedral shear stress); (2) the vibration shear modulus decreases with increasing void ratio and Eq. 4 in the paper is a fair representation of the effect of void ratio; the effects of structure seem to be mostly accounted for by the void ratio parameter; (3) considering the isotropic component of ambient effective stress (effective octahedral normal stress), σ¯ 0 , as an independent variable, and not including the effects of void ratio and secondary time effects, the vibration shear modulus varies with σ¯ 0 to the 0.5 power; and (4) there is a secondary increase of the vibration shear modulus with time, at constant effective stress, not accounted for by changes in void ratio. This stiffness build-up is sensitive to particle disturbance and can be partially or totally destroyed by changes in effective stress. This effect may be quite important for soils in situ.
Micro- and nanosystems based on vibrating structures

Invention of the scanning force microscope in 1986 and development of micro and nanofabrication technologies yielded a new generation of vibration based miniature sensors of physical, chemical and biological parameters, with sensitivity which could not be achieved before. This promoted again the research of micro and nanoelectromechanical systems (MEMS and NEMS) in the fields that have been dominated by semiconductor electronics for more than a half of century. In this paper the principles of operation of the miniature vibrating structures are given. A particular attention is given to the fact that the mass of these structures is of the order of tens of picograms, and that their dimensions can be in the sub- micrometer range, where the effects of Brownian motion of particles in the surroundings become significant. These effects are expressed as thermomechanical noise which in most cases determines the ultimate sensor performances. Also, adsorption and desorption (AD) of particles (atoms, molecules) on the surface of miniature vibrating structures generate the AD noise. Vibrating micro- and nanostructures are important not only for the new sensor components, but also for a multitude of other applications. As an illustration, I will mention a new generation of MEMS oscillators, which successfully replaces the traditional quartz oscillators in some contemporary applications. Also, a new generation of processors which utilize built-in miniature mechanical structures is envisioned.
Malignant lymphoma associated with hydantoin drugs.

LYMPHADENOPATHY has been recognized as one of the less common side effects of the hydantoin drugs 1-3 for more than a quarter of a century. These drugs have been available for the treatment of epilepsy since 1938. Lymphadenopathy in these patients had been considered a hypersensitivity reaction because of the frequent occurrence of eosinophilia, and benign since it disappeared with discontinuation of the hydantoin. There is a dearth of knowledge about the mechanism of hydantoin lymphadenopathy. The benignancy of this lymphadenopathy has been questioned. 4-6 Great difficulty has been encountered in the differentiation between "benign" and malignant lymphoid reactions in general. 4 Hyman and Sommers 7 reported six cases of lymphoma in association with hydantoin therapy. A study was undertaken with the hope of clarifying the relationship between hydantoin therapy and malignant lymphoma. A review of the literature was processed, and then a retrospective study of necropsies undertaken to
Making a Sophisticated Symbolic Solver Available to Different Communities of Users

Triangular decompositions have become one of the major tools for solving systems of non-linear algebraic or differential equations symbolically. These decompositions display more geometrical information than other symbolic descriptions of polynomial systems. However, their specifications and the algorithms computing them are quite sophisticated. Their implementation in mathematical software, their accessibility, and ease of use for non-expert users are challenges that we discuss in this paper. We discuss our solutions and illustrate them with the implementation of an algorithm for triangular decompositions, called Triade, in three computer algebra systems: AXIOM, ALDOR, and MAPLE, targeting different communities of users. We believe that these implementations of the same sophisticated mathematical algorithm for different communities of experts, advanced users, and non-experts is a unique experience in the area of symbolic computations which could benefit other algorithms in this field.
Non-canonical ubiquitin-based signals for proteasomal degradation

Regulated cellular proteolysis is mediated largely by the ubiquitin–proteasome system (UPS). It is a highly specific process that is time- (e.g. cell cycle), compartment- (e.g. nucleus or endoplasmic reticulum) and substrate quality- (e.g. denatured or misfolded proteins) dependent, and allows fast adaptation to changing conditions. Degradation by the UPS is carried out through two successive steps: the substrate is covalently tagged with ubiquitin and subsequently degraded by the 26S proteasome. The accepted ‘canonical’ signal for proteasomal recognition is a polyubiquitin chain that is anchored to a lysine residue in the target substrate, and is assembled through isopeptide bonds involving lysine 48 of ubiquitin. However, several ‘non-canonical’ ubiquitin-based signals for proteasomal targeting have also been identified. These include chains anchored to residues other than internal lysine in the substrates, chains assembled through linking residues other than lysine 48 in ubiquitin, and mixed chains made of both ubiquitin and a ubiquitin-like protein. Furthermore, some proteins can be degraded following modification by a single ubiquitin (monoubiquitylation) or multiple single ubiquitins (multiple monoubiquitylation). Finally, some proteins can be proteasomally degraded without prior ubiquitylation (the process is also often referred to as ubiquitination). In this Commentary, we describe these recent findings and discuss the possible physiological roles of these diverse signals. Furthermore, we discuss the possible impact of this signal diversity on drug development.
Logarithmic Opinion Pools for Conditional Random Fields

Recent work on Conditional Random Fields (CRFs) has demonstrated the need for regularisation to counter the tendency of these models to overfit. The standard approach to regularising CRFs involves a prior distribution over the model parameters, typically requiring search over a hyperparameter space. In this paper we address the overfitting problem from a different perspective, by factoring the CRF distribution into a weighted product of individual "expert" CRF distributions. We call this model a logarithmic opinion pool (LOP) of CRFs (LOP-CRFs). We apply the LOP-CRF to two sequencing tasks. Our results show that unregularised expert CRFs with an unregularised CRF under a LOP can outperform the unregularised CRF, and attain a performance level close to the regularised CRF. LOP-CRFs therefore provide a viable alternative to CRF regularisation without the need for hyperparameter search.
Incidence and Predictors of Pacemaker Implantation in Patients Undergoing Transcatheter Aortic Valve Replacement

Transcatheter aortic valve replacement (TAVR) has emerged as an alternative treatment for patients with symptomatic aortic stenosis who are at high risk for surgical aortic valve replacement. The development of conduction abnormalities is a major complication in the postprocedural period of TAVR.
Security Assessment of Cyberphysical Digital Microfluidic Biochips

A digital microfluidic biochip (DMFB) is an emerging technology that enables miniaturized analysis systems for point-of-care clinical diagnostics, DNA sequencing, and environmental monitoring. A DMFB reduces the rate of sample and reagent consumption, and automates the analysis of assays. In this paper, we provide the first assessment of the security vulnerabilities of DMFBs. We identify result-manipulation attacks on a DMFB that maliciously alter the assay outcomes. Two practical result-manipulation attacks are shown on a DMFB platform performing enzymatic glucose assay on serum. In the first attack, the attacker adjusts the concentration of the glucose sample and thereby modifies the final result. In the second attack, the attacker tampers with the calibration curve of the assay operation. We then identify denial-of-service attacks, where the attacker can disrupt the assay operation by tampering either with the droplet-routing algorithm or with the actuation sequence. We demonstrate these attacks using a digital microfluidic synthesis simulator. The results show that the attacks are easy to implement and hard to detect. Therefore, this work highlights the need for effective protections against malicious modifications in DMFBs.
Computer-aided design of modular protein devices: Boolean AND gene activation

Many potentially useful synthetic gene networks require the expression of an engineered gene if and only if two different DNA-binding proteins exist in sufficient concentration. While some natural and engineered systems activate gene expression according to a logical AND-like behavior, they often utilize allosteric or cooperative protein–protein interactions, rendering their components unsuitable for a toolbox of modular parts for use in multiple applications. Here, we develop a quantitative model to demonstrate that a small system of interacting fusion proteins, called a protein device, can activate an engineered gene according to the Boolean AND behavior while using only modular protein domains and DNA sites. The fusion proteins are created from transactivating, DNA-binding, non-DNA binding, and protein–protein interaction domains along with the corresponding peptide ligands. Using a combined kinetic and thermodynamic model, we identify the characteristics of the molecular components and their rates of constitutive production that maximize the fidelity of AND behavior. These AND protein devices facilitate the creation of complex genetic programs and may be used to create gene therapies, biosensors and other biomedical and biotechnological applications that turn on gene expression only when multiple DNA-binding proteins are simultaneously present.