Miracle-dz/UniFAR-FTUs huggingface dataset:
Genetic Detection and Isolation of Crimean-Congo hemorrhagic fever virus, Kosovo, Yugoslavia

Crimean-Congo hemorrhagic fever virus (C-CHFV) strains were isolated from a fatal case and the attending physician in Kosovo, Yugoslavia. Early, rapid diagnosis of the disease was achieved by reverse transcription-polymerase chain reaction. The physician was successfully treated with oral ribavirin. These cases yielded the first genetically studied C-CHFV human isolates in the Balkans.
Adaptive Modulation for Maximizing Practicable Sum Capacity in MU-MISO Downlink

This paper addresses adaptive modulation and power allocation for maximizing the practicable sum capacity (sum of the uncoded throughputs of the users) of a multiuser multiple-input single-output MU-MISO) system. Since the optimal solution, dirty paper encoding (DPC), is complicated to implement, we use the simpler linear precoding based on signal- to-leakage-plus-noise ratio (SLNR). For different choices of constellation sizes, the maximum practicable sum capacities and their corresponding optimal power allocations are obtained via individual non-convex optimization. The best constellation sizes for each user are then identified through a search for the highest maximized practicable sum capacity. Simulations demonstrate the significant performance improvement from this approach compared to existing power allocation schemes. Finally, a selection procedure between different constellation sets is presented to obtain the highest practicable sum capacity while maintaining the instantaneous BER of each user below a target value. This approach allows management of the trade-off between the capacity and error performances.
Effects of Training on Neuronal Activity and Interactions in Primary and Higher Visual Cortices in the Alert Cat

The effects of behavioral training on early visual representations have been elusive when assessed with firing rates. Learning-induced changes in performance, however, suggest that representations should encompass early cortical stages. Here, we address the question of whether training-induced effects are pertinent to neuronal activity outside the task proper, which is a requirement if subsequent perceptional processes should profit from training. To search for a neuronal signature of training effects beyond firing rates, we measured local field potentials, multiunit and isolated spike activity during passive viewing of previously learned stimulus response associations (S+ and S-) in areas 17/18 and 21a of two alert cats. Evoked potential responses as well as gamma oscillations even during the first 200 msec were found to be stronger for S+ in both areas. Most importantly, the later parts of the response (>200 msec) not only exhibit a highly significant difference in coherent gamma oscillations for S+ and S- both within and across areas, but are also characterized by a pronounced preference in firing rate for S+ in area 21a, whereas primary cortex shows a nonsignificant trend for weaker spike responses. From these results, we conclude that training-induced plasticity occurs in adult visual cortex for behaviorally relevant stimuli by changing primarily the temporal structure of neuronal activity at early stages of cortical processing, whereas later stages of cortical processing express the increased coherence of their input in elevated firing rates.
Immunogenicity of Two Investigational Serogroup B Meningococcal Vaccines in the First Year of Life: A Randomized Comparative Trial

Background: An investigational vaccine against serogroup B meningococcal (MenB) disease containing 3 main recombinant proteins (factor H-binding protein, Neisserial adhesion A, and Neisserial heparin-binding antigen) has been developed. We evaluated the immunogenicity and reactogenicity of a 3-dose course of this vaccine administered alone (recombinant MenB [rMenB]) or combined with the outer membrane vesicle (OMV) component of the vaccine used in New Zealand (rMenB+OMV). Methods: A randomized, single-blind, comparative study of 60 healthy infants enrolled at 6 to 8 months of age and immunized with rMenB or rMenB+OMV at day 0, day 60, and at age 12 months. Blood samples obtained at baseline and 1 month following the second and third doses of vaccine were analyzed for serum bactericidal antibody (SBA) using human complement (hSBA) against 7 MenB strains. The putative correlate of protection was an hSBA titer of ≥4. Results: The per-protocol analysis included 24 of 30 participants randomized to each group. After 3 doses of rMenB+OMV, 90% or more of participants had an hSBA titer ≥4 for 5 MenB strains, with 70% of participants having an hSBA titer ≥4 for a sixth strain. rMenB alone was immunogenic for only 3 strains. Both vaccines were well tolerated. Conclusions: Three doses of rMenB+OMV in the second half of infancy induce bactericidal antibodies against strains expressing vaccine antigens, demonstrating the potential for broader vaccine prevention of MenB disease. This vaccine is now in phase III clinical trials.
In Vivo Anti-Inflammatory and Analgesic Effects of Aqueous Extract of Cistus ladanifer L. From Morocco

This study is designed to evaluate the analgesic and anti-inflammatory activities of aqueous extract (AE) of Cistus ladanifer L. leaves in experimental animal models. The central analgesic activity of C. ladanifer AE is studied using hot plate method in rats, and the acute anti-Inflammatory activity of C. ladanifer is investigated by rats paw edema induced by subplantar injection of 0.5% carrageenan into the right hind paw. Rats are pretreated with AE of C. ladanifer at different doses (150, 175, and 200 mg/kg, i.p.). The tramadol and indomethacin are used as reference drugs for analgesic and anti-inflammatory studies, respectively. Our results show that the AE of C. ladanifer exhibited anti-inflammatory and analgesic effects dose dependent. In anti-inflammatory activity, the AE of C. ladanifer at all doses reduced significantly the edema paw inflammation after carrageenan injection. Furthermore at 200 mg/kg, the effect of AE is highly important than that of other doses. In addition, the same AE demonstrates significant analgesic effect in thermal-induced pain model. So, this activity is proved by significant reduction of pain score after administration of AE at all doses. The nociception protection effects in this case are, respectively, 70.3%, 74.55%, and 93.33% after administration of AE of C. ladanifer at doses 150, 175, and 200 mg/kg b.w. The results of our findings suggest that AE of C. ladanifer has potential analgesic and anti-inflammatory activities with evidence of possible involvement of peripheral and central effects in its actions.
TINJAUAN DAN PEMBENTUKAN MODEL ANALISIS TINGKAT PENERIMAAN TEKNOLOGI E-GOVERNMENT NUSA TENGGARA BARAT

ABSTRAK Penelitian ini mencoba menganalisis model yang tepat dalam menganalisis tingkat penerimaan pegawai pemerintah dan masyarakat terhadap teknologi e-government di Nusa Tenggara Barat. Beberapa model di analisa kelayakan faktor dan kesesuaian terapan dengan melihat banyaknya implementasi terapan metode tersebut dalam konteks e-government di beberapa penelitian sejenis. Beberapa konstruk dibahas dan dimodifikasi sesuai dengan perkembangan dan kesesuaian kebutuhan. Hasil memberikan model baru yaitu UTAUT2 Modifikasi dengan mengabungkan model yang telah popular digunakan yaitu Technology Acceptance Model (TAM), Unified Theory of Acceptance and Use of Technology (UTAUT), Unified Theory of Acceptance and Use of Technology 2 (UTAUT2) dan Unified Theory of Acceptance and Use of Technology (UTAUT) dengan variabel tambahan oleh Faris Ash-Shobi dalam penelitiannya; model yang dibentuk disusun dengan memperluas cakupan variabel yang digunakan dalam analisis untuk dapat mengukur dan memodelkan bentuk model paling mendekati untuk dapat mengambarkan model penerimaan masyarakat terhadap penerimaan dan penggunaan teknologi e-government di Nusa Tenggara Barat. Kata kunci: e-government, model penerimaan dan penggunaan teknologi, TAM, UTAUT, UTAUT2, UTAUT2 Modifikasi ABSTRACT This study tries to analyze the right model in analyzing the level of government and community employee acceptance of e-government technology in West Nusa Tenggara. Several models in the feasibility analysis of the applied factors and suitability by looking at the number of applied implementations of the method in the context of e-government in several similar studies. Some constructs are discussed and modified according to the development and suitability of needs. The results provide a new model that is UTAUT2 Modification by combining the models that have been popularly used, namely Technology Acceptance Model (TAM), Unified Theory of Acceptance and Use of Technology (UTAUT), Unified Theory of Acceptance and Use of Technology 2 (UTAUT2) and Unified Theory of Acceptance and Use of Technology (UTAUT) with additional variables by Faris Ash-Shobi in his research; the model formed is structured by extending the range of variables used in the analysis to be able to measure and model the model form most closely to be able to describe the model of public acceptance of the acceptance and use of e-government technology in West Nusa Tenggara. Keywords: e-government, accept and use of technology model, TAM, UTAUT, UTAUT2, UTAUT2 Modification
Synthesis of testable PLAs using adaptive heuristics for efficiency

The problem of integrating testability issues into the synthesis process of programmable-logic-array (PLA-)based VLSI logic design is investigated. Based on the insight gained from prior work on algorithmic and heuristic test generation for PLAs, a systematic methodology for synthesizing easily testable PLAs from high-level (Boolean) specifications is developed. Experimental results are presented to illustrate how adaptive heuristics aid in reducing the complexity of the synthesis-for-testability problem. <<ETX>>
An Educational Asynchronous Learning Environment

In this paper we propose an educational asynchronous learning environment which makes students more interactive in learning process. Our system lets students collaborate among them in order to construct their knowledge as much as possible and to find solutions of many problems that occur during learning. In this paper, we focus on question and answer (adaptive evaluation: AE) as a collaboration tool for students based on Web technology, because AE has the characteristics that ensures and checks students' comprehension of material without any restriction of time and place. In our system students can act as questioners who ask some questions collaboratively to acquire additional knowledge, or act as respondents who answer questions from other students. Using this environment, the interactive learning of students can be achieved, and also the teacher's load can be decreased.
Comparitive Analysis of Lambda Iteration Method and Particle Swarm Optimization for Economic Emission Dispatch Problem

With the increase in energy demands, it becomes necessary to operate the thermal power plants most economically, which gives rise to Economic Load Dispatch (ELD) problem. The problem of ELD in power system is to plan the power output for each committed generating unit in such a way that operating cost is minimized while meeting load demand, power operating limits. In present scenario, expansion in power generation has resulted to increase in emissions in the environment which is the prime concern for power system planners. In order to get clean energy, emission control has become an important operational objective in addition to minimization of operating cost. The combination of both the objectives i.e. economic dispatch and emission dispatch have resulted in multi-dimensional power system optimization problem called Economic Emission Dispatch (EED) problem. In this paper, EED problem has been solved using Lambda Iteration Method and Particle Swarm Optimization (PSO) technique. Both the solution methodologies have been validated on three generator system and five generator system. Comparative analysis of the results obtained by both the methods has been performed. Keywords— Economic Load Dispatch, Economic Emission Dispatch, Lambda Iteration Method, Particle Swarm Optimization.
Low-Leakage ESD Power Clamp Design With Adjustable Triggering Voltage for Nanoscale Applications

A low-leakage electrostatic discharge power clamp with adjustable triggering voltage (<inline-formula> <tex-math notation="LaTeX">${V}_{t1})$ </tex-math></inline-formula> is proposed in this paper. By enabling the static detection path using the transient one, the proposed clamp achieves a wide range of adjustable <inline-formula> <tex-math notation="LaTeX">${V}_{t1}$ </tex-math></inline-formula> while maintaining low standby leakage current (<inline-formula> <tex-math notation="LaTeX">${I}_{\text {leak}})$ </tex-math></inline-formula>, which overcomes the flaw of traditional static clamps. Besides, the adjustable <inline-formula> <tex-math notation="LaTeX">${V}_{t1}$ </tex-math></inline-formula> with low <inline-formula> <tex-math notation="LaTeX">${I}_{\text {leak}}$ </tex-math></inline-formula> is attractive for nanoscale applications. Moreover, the proposed clamp achieves enhanced false-triggering immunity over traditional transient clamps. The proposed clamp is successfully verified in a 65-nm CMOS process. Aside from silicon verifications, detailed comparisons with prior arts and practical application concerns are also addressed in this paper.
Vitamin D metabolism. Recent advances.

Knowledge of the mode of action and metabolism of vitamin D has made rapid progress in the past few years. The discovery that ingested vitamin D undergoes transformation to a circulating metabolite, that this metabolite then undergoes further transformation into a more biologically active form, and that production of these metabolites may be subject to feedback control mechanisms, has led to the recognition that 'vitamin D' could be regarded as a hormone as well as a vitamin. This hormonal concept of the antirickets agent is far from new, however, for in 1919, the same year that Mellanby discovered that cod liver oil could cure rickets, Huldschinsky (quoted by Loomis, 1970) showed that ultraviolet irradiation of a single limb would cure rickets not only in the irradiated limb but in the other limbs as well; these findings had thus already fulfilled the criteria of a hormone as a substance synthesized at one site in the body and exerting a powerful metabolic effect at a site distant from the point of synthesis. The nature of this effect has now become clearer, and the purpose of the present review is to trace the most recent developments in this field and their bearing on problems in clinical medicine. Much of our knowledge of the physiology of vitamin D is summarized in Fig 1. Cholecalciferol (vitamin D3) and possibly other antirachitic compounds are formed in the skin by the action of ultraviolet irradiation on the physiological precursor 7-dehydrocholesterol. 7-Dehydrocholesterol synthesis is active in both liver and skin (Gaylor and Sault, 1964), but the exact way in which its irradiation products are absorbed through the skin in man is uncertain. Early studies (Helmer and Jansen, 1937a, b) showed that antirachitic material was recoverable from human skin washings and that cholecalciferol could cure rickets when applied to unbroken animal skin. More recently Gaylor and Sault (1964) observed that the concentration
Environmental exposures and cancer: using the precautionary principle*

Since the 1970s, more than 87,000 chemicals have been approved for commercial use. Yet of those thousands of chemicals, only just over one thousand have been formally examined and graded for their carcinogenic potential. Of those, five hundred have been found worthy of being graded on a cautiously worded scale ranging from “known” carcinogens to “possibly” carcinogenic. In addition to carcinogenic substances, a new field has emerged researching how environmental toxins cause endocrine or hormonal disruption. A class of these compounds known as endocrine-disrupting chemicals (EDCs) can be found in our food, our environment, and in the products we put on our bodies. Rather than being directly linked to causing cancer, like substances such as asbestos, EDCs influence our health by mimicking or enhancing or changing metabolic regulation. These compounds interfere with hormone production and metabolism in ways that may—especially over the long term—create biological conditions that make us more susceptible to cancer and other diseases. Most of us are exposed to a cocktail of environmental toxins on an ongoing daily basis and at a relatively low level of exposure. Given the lax regulation of chemicals and the reactionary approach of government regulators, it is up to the consumer to be diligent about reading labels and making healthy choices to limit exposure to chemicals and toxins. It is ideal to adopt the Precautionary Principle: until a chemical is found to be harmless, try to not use it. The precautionary principle means that you are maintaining awareness of what you are putting on and in your body and taking steps to avoid exposing yourself unnecessarily to toxins in your household and environment.
Reduced-Order Electrochemical Model Parameters Identification and SOC Estimation for Healthy and Aged Li-Ion Batteries Part II : Aged Battery Model and State of Charge Estimation T

This article has been accepted for publication in a future issue of this journal, but has not been fully edited. Content may change prior to final publication. Abstract— Recently, extensive research has been conducted in the field of battery management systems due to increased interest in vehicles electrification. Parameters such as battery state of charge and state of health are of critical importance to ensure safety, reliability, and prolong battery life. This paper includes the following contributions: (1) tracking reduced-order electrochemical battery model parameters variations as battery ages, using non-invasive genetic algorithm optimization technique, (2) the development of a battery aging model capable of capturing battery degradation by varying the effective electrode volume, (3) estimation of the battery critical state of charge using a new estimation strategy known as the Smooth Variable Structure Filter based on reduced-order electrochemical model. The proposed filter is used for state of charge estimation, and demonstrates strong robustness to modeling uncertainties which is relatively high in case of reduced-order electrochemical models. Batteries used in this research are lithium-Iron Phosphate cells widely used in automotive applications. Extensive testing using real-world driving cycles are used for estimation strategy application and for conducting the aging test. Limitations of the proposed strategy are also highlighted. Index Terms— Lithium-Ion Batteries, electrochemical battery model, state of charge estimation, state of health estimation, smooth variable structure filter.
Recognizing encephalopathy and delirium in the cardiopulmonary rehabilitation setting.

OBJECTIVE This article reviews the prevalence, underlying mechanisms, and challenges of treating encephalopathy and delirium in the postsurgical and medically compromised cardiopulmonary patient receiving services on an acute inpatient rehabilitation unit. Additionally, pertinent information is provided on conducting an evaluation to assess for neurocognitive sequelae of the above-mentioned conditions to help achieve better treatment outcomes. METHOD Review of the medical and neuropsychology literature is provided along with 2 case reports to illustrate evaluation of a persisting toxic-metabolic encephalopathy and a resolving delirium and the treatment team's effectiveness in producing a more optimal treatment outcome. The unique role of the rehabilitation psychologist, special treatment considerations, and the importance of integrated follow-up neurorehabilitation services for the cardiopulmonary patient and caregivers also are emphasized. RESULTS Encephalopathy and delirium are 2 related, but somewhat different, conditions that can emerge postoperatively, any time during acute care hospitalization, and often enough, during impatient or subacute-care rehabilitation. Their association with long-term harm and poor outcome warrant early identification and immediate medical intervention. IMPLICATIONS Encephalopathy and delirium can significantly affect rehabilitation outcomes and, as such, rehabilitation psychologists are encouraged to systematically screen for the presence of delirium and encephalopathy in the cardiopulmonary rehabilitation setting so to enhance treatment efficacy and quality of life in affected individuals.
Standardized ‘no‐touch’ donor tissue preparation for DALK and DMEK: harvesting undamaged anterior and posterior transplants from the same donor cornea

Purpose: To describe a standardized ‘no‐touch’ harvesting technique of anterior and Descemet membrane (DM) grafts for use in deep anterior lamellar keratoplasty (DALK) and Descemet membrane endothelial keratoplasty (DMEK), which provides undamaged anterior and posterior corneal grafts.
Scale-Free Random SAT Instances

We focus on the random generation of SAT instances that have properties similar to real-world instances. It is known that many industrial instances, even with a great number of variables, can be solved by a clever solver in a reasonable amount of time. This is not possible, in general, with classical randomly generated instances. We provide a different generation model of SAT instances, called scale-free random SAT instances. This is based on the use of a non-uniform probability distribution P(i)∼i−β to select variable i, where β is a parameter of the model. This results in formulas where the number of occurrences k of variables follows a power-law distribution P(k)∼k−δ, where δ=1+1/β. This property has been observed in most real-world SAT instances. For β=0, our model extends classical random SAT instances. We prove the existence of a SAT–UNSAT phase transition phenomenon for scale-free random 2-SAT instances with β<1/2 when the clause/variable ratio is m/n=1−2β(1−β)2. We also prove that scale-free random k-SAT instances are unsatisfiable with a high probability when the number of clauses exceeds ω(n(1−β)k). The proof of this result suggests that, when β>1−1/k, the unsatisfiability of most formulas may be due to small cores of clauses. Finally, we show how this model will allow us to generate random instances similar to industrial instances, of interest for testing purposes.