Miracle-dz/UniFAR-FTUs huggingface dataset:
A Generalized Analysis of Multiple-clad Optical Fibers with Arbitrary Step- Index Profiles and Applications

A generalized analysis of multiple-clad cylindrical dielectric structures with step-index profiles is presented. This analysis yields unified expressions for fields, dispersion equation and cutoff conditions for weakly guiding optical fibers with step-index but otherwise arbitrary profiles. The formulation focuses on triple-clad fibers, but can accommodate single and double-clad fibers as special limiting cases. Using the generalized solutions, transmission properties of several types of specialty fibers for broadband applications, including dispersion-shifted, dispersion-flattened, and dispersion compensating fibers, are studied. Improved designs for dispersion-shifted and dispersion compensating fibers are achieved. Fiber parameters and material compositions for the improved designs are provided. The proposed design for the dispersion-shifted fiber yields zero second-order as well as third-order dispersion at the λ µ = 155. m wavelength. The dispersion compensating fiber proposed here provides a large negative dispersion of about −400 ps nm km /. at λ µ = 155. m for the fundamental mode. Numerical results for dispersion characteristics, cutoff wavelengths, and radial field distributions are provided. iii Acknowledgments
Varicella-Zoster Virus Open Reading Frame 10 Is a Virulence Determinant in Skin Cells but Not in T Cells In Vivo

ABSTRACT The open reading frame 10 (ORF10) of varicella-zoster virus (VZV) encodes a tegument protein that enhances transactivation of VZV genes and has homology to herpes simplex virus type 1 (HSV-1) VP16. While VP16 is essential for HSV replication, ORF10 is dispensable for vaccine OKA (VOKA) growth in vitro. We used parent OKA (POKA) cosmids to delete ORF10, producing POKAΔ10; point mutations that disrupted the acidic activation domain and the putative motif for binding human cellular factor 1 (HCF-1) in ORF10 protein yielded POKA10-Phe28Ala, POKA10-Phe28Ser, and POKA10-mHCF viruses. Deleting ORF10 or mutating these two functional domains had no effect on VZV replication, immediate-early gene transcription, or virion assembly in vitro. However, deleting ORF10 reduced viral titers and the extent of cutaneous lesions significantly in SCIDhu skin xenografts in vivo compared to POKA. Epidermal cells infected with POKAΔ10 had significantly fewer DNA-containing nucleocapsids and complete virions compared to POKA; extensive aggregates of intracytoplasmic viral particles were also observed. Altering the activation or the putative HCF-1 domains of ORF10 protein had no consequences for VZV replication in vivo. Thus, the decreased pathogenic potential of POKAΔ10 in skin could not be attributed to absence of these ORF10 protein functions. In contrast to skin cells, deleting ORF10 did not impair VZV T-cell tropism in vivo, as assessed by infectious virus yields. We conclude that ORF10 protein is required for efficient VZV virion assembly and is a specific determinant of VZV virulence in epidermal and dermal cells in vivo.
Development of FPGA Toolbox for Implementation of Spiking Neural Networks

Since more and more new findings and principles of intelligence emerge from neuroscience, spiking neural networks become important topics in artificial intelligence domain. However, as high computational complexity of spiking neural networks it is difficult to implement them efficiently using software simulation. In this paper a new hardware implementation method is proposed. In order to implement spiking neural networks more simply, efficiently and rapidly, a toolbox, which is composed of components of spiking neural networks, is developed for neuroscientists, computer scientists and electronic engineers to implement and simulate spiking neural networks in hardware. Using the toolbox a spiking neural network is easy to implement on a FPGA (Field Programmable Gate Arrays) chip, because the toolbox takes advantages of Xilinx System Generator and works in Mat lab Simulink environment. The graphic user interface enables users easy to design and simulate spiking neural networks on FPGAs and speed up run-time. This paper presents the methodology in development of the toolbox and the examples are used to show its promising application.
Vision-based global localization based on a hybrid map representation

In this paper we propose a novel vision-based global localization method based on a hybrid map representation. We employ PCA-SIFT features as visual landmarks and represent the environment with a hybrid map which consists of a global topological map and local metric maps. To localize where a mobile robot is placed, we extract visual features from the currently captured view and match them to the feature database previously constructed according to the hybrid map representation. After filtering noise, we estimate the robotpsilas pose with the qualified matching features by the RANSAC approach. We implemented the proposed method in a real mobile robot and tested in both a home-like room and an office-like corridor. The experimental results show that our vision-based global localization system is acceptable in terms of processing time and accuracy.
Can camera trapping provide accurate estimates of small mammal (Myodes rutilus and Peromyscus maniculatus) density in the boreal forest?

Estimating population densities of small mammals (< 100 g) has typically been carried out by intensive livetrapping, but this technique may be stressful to animals and the effort required is considerable. Here, we used camera traps to detect small mammal presence and assessed if this provided a feasible alternative to livetrapping for density estimation. During 2010–2012, we used camera trapping in conjunction with mark-recapture livetrapping to estimate the density of northern red-backed voles (Myodes rutilus) and deer mice (Peromyscus maniculatus) in the boreal forest of Yukon, Canada. Densities for these 2 species ranged from 0.29 to 9.21 animals/ha and 0 to 5.90 animals/ha, respectively, over the course of this investigation. We determined if hit window—the length of time used to group consecutive videos together as single detections or “hits”—has an effect on the correlation between hit rate and population density. The relationship between hit rate and density was sensitive to hit window duration for Myodes with R2 values ranging from 0.45 to 0.59, with a 90-min hit window generating the highest value. This relationship was not sensitive to hit window duration for Peromyscus, with R2 values for the tested hit windows ranging from 0.81 to 0.84. Our results indicate that camera trapping may be a robust method for estimating density of small rodents in the boreal forest when the appropriate hit window duration is selected and that camera traps may be a useful tool for the study of small mammals in boreal forest habitat.
Clinical Outcome and Fusion Rates after the First 30 Extreme Lateral Interbody Fusions

Introduction. The lateral transpsoas approach for lumbar interbody fusion (XLIF) is gaining popularity. Studies examining a surgeon's early experience are rare. We aim to report treatment, complication, clinical, and radiographic outcomes in an early series of patients. Methods. Prospective data from the first thirty patients treated with XLIF by a single surgeon was reviewed. Outcome measures included pain, disability, and quality of life assessment. Radiographic assessment of fusion was performed by computed tomography. Results. Average follow-up was 11.5 months, operative time was 60 minutes per level and blood loss was 50 mL. Complications were observed: clinical subsidence, cage breakage upon insertion, new postoperative motor deficit and bowel injury. Approach side-effects were radiographic subsidence and anterior thigh sensory changes. Two patients required reoperation; microforaminotomy and pedicle screw fixation respectively. VAS back and leg pain decreased 63% and 56%, respectively. ODI improved 41.2% with 51.3% and 8.1% improvements in PCS and MCS. Complete fusion (last follow-up) was observed in 85%. Conclusion. The XLIF approach provides superior treatment, clinical outcomes and fusion rates compared to conventional surgical approaches with lowered complication rates. Mentor supervision for early cases and strict adherence to the surgical technique including neuromonitoring is essential.
Studies of the pathogenesis of wild‐type virus and six temperature‐sensitive mutants of mouse cytomegalovirus

A comparison of six temperature‐sensitive (ts) mutants with the parental wild‐type (wt) virus showed that, when 1‐week‐old BALB/c mice were inoculated intraperitoneally with 300 pfu of mouse passaged virus, the viruses could be broadly categorized into two groups. Two viruses (wt and tsm6) were lethal at this dose (10 and 2 LD50 respectively); animals died within 4–6 days of inoculation and the virus became generalized infecting heart, lung, liver, spleen, kidney, and salivary glands to high titre (>4.3 log10 pfu/ g). In contrast, for viruses (tsm1,tsm3, and tsm4) not lethal at this dose (300 pfu = 0.1 to 0.25 LD50), viral replication was poor (<3.4 log10 pfu/g) except in the salivary glands (5.6 to 7.5 log10 pfu/g). Mutant tsm5 failed to replicate in any tissue while mutant tsm2, lethal at this dose (300 pfu = 1 LD50), produced levels of virus similar to those found with tsm1, tsm3, and tsm4. Comparison of all viruses at sub‐lethal doses (0.1 to 0.25 LD50) did show minor differences in their replication in heart, and in levels of virus and duration of infection in kidney and salivary glands. More marked differences were evident between the viruses in their ability to be reactivated from the latent state during immunosuppression. Wild‐type virus was most easily reactivated in that 67% of animals exhibited virus in salivary glands, heart, lung, spleen, and kidney. Mutants tsm1, tsm2, tsm3 and tsm6 could be reactivated but from fewer animals (33%, 33%, 18%, and 38% respectively) and fewer tissues. Mutants tsm4 and tsm5 could not be reactivated. Differences in the ability of the viruses to replicate in the lungs and to cause penumonitis in intranasally‐inoculated immunosuppressed mice were also seen. Although immunosuppression was necessary for the induction of severe pneumonitis, differences in severity of pneumonitis resulted from differences in the ability of the mutants to replicate in the lung in vivo. These different mutants should prove useful for examining the viral and host factors involved in CMV‐induced pneumonitis, and for examining mechanisms involved in latency and reactivation. © 1994 Wiley‐Liss, Inc.
Molecular Mechanisms Involved in the Pathogenesis of Alphavirus-Induced Arthritis

Arthritogenic alphaviruses, including Ross River virus (RRV), Chikungunya virus (CHIKV), Sindbis virus (SINV), Mayaro virus (MAYV), O'nyong-nyong virus (ONNV), and Barmah Forest virus (BFV), cause incapacitating and long lasting articular disease/myalgia. Outbreaks of viral arthritis and the global distribution of these diseases point to the emergence of arthritogenic alphaviruses as an important public health problem. This review discusses the molecular mechanisms involved in alphavirus-induced arthritis, exploring the recent data obtained with in vitro systems and in vivo studies using animal models and samples from patients. The factors associated to the extension and persistence of symptoms are highlighted, focusing on (a) virus replication in target cells, and tissues, including macrophages and muscle cells; (b) the inflammatory and immune responses with recruitment and activation of macrophage, NK cells and T lymphocytes to the lesion focus and the increase of inflammatory mediators levels; and (c) the persistence of virus or viral products in joint and muscle tissues. We also discuss the importance of the establishment of novel animal models to test new molecular targets and to develop more efficient and selective drugs to treat these diseases.
Patchy Distributions of Competitors Affect the Growth of a Clonal Plant When the Competitor Density Is High

Environments are patchy in not only abiotic factors but also biotic ones. Many studies have examined effects of spatial heterogeneity in abiotic factors such as light, water and nutrients on the growth of clonal plants, but few have tested those in biotic factors. We conducted a greenhouse experiment to examine how patchy distributions of competitors affect the growth of a rhizomatous wetland plant Bolboschoenus planiculmis and whether such effects depend on the density of the competitors. We grew one ramet of B. planiculmis in the center of each of the experimental boxes without competitors (Schoenoplectus triqueter), with a homogeneous distribution of the competitors of low or high density, and with a patchy distribution of the competitors of low or high density. The presence of competitors markedly decreased the growth (biomass, number of ramets, number of tubers and rhizome length) of the B. planiculmis clones. When the density of the competitors was low, the growth of B. planiculmis did not differ significantly between the competitor patches and competitor-free patches. However, when the density of the competitors was high, the growth of B. planiculmis was significantly higher in the competitor-free patches than in the competitor patches. Therefore, B. planiculmis can respond to patchy distributions of competitors by placing more ramets in competition-free patches when the density of competitors is high, but cannot do so when the density of competitors is low.
Perceptions of social conflicts among incarcerated adolescents with callous-unemotional traits: 'you're going to pay. It's going to hurt, but I don't care.'.

BACKGROUND Delinquent youth with callous-unemotional (CU) traits may have a unique social-cognitive processing pattern that perpetuates their violent behavior. The current study examined the association between CU traits and the endorsement of deviant social goals during peer conflicts as well as expectancies and values regarding victim suffering following aggression. METHODS Participants included 156 (84 males, 72 females) adjudicated juveniles residing at two gender-specific residential facilities in an urban city within the southeastern United States. The association between CU traits and participants' ratings of their social goals in hypothetic conflict situations and outcome expectancies/values regarding victim suffering were examined after controlling for prior violence, intelligence, and demographic covariates. RESULTS CU traits were associated with an increased endorsement of social goals associated with revenge, dominance, and forced respect in social conflict situations. Adjudicated youth with CU traits were also less likely to endorse conflict avoidance and friendship building as important social goals when provoked by peers. There was no association between CU traits and expectations for victim suffering following aggression, but CU traits were significantly associated with lower levels of concern about victim suffering. These findings were significant after controlling for participants' prior history of violence, intelligence, and demographic covariates. CONCLUSIONS Adjudicated youth with CU traits tend to emphasize power-oriented goals when provoked by peers and have little interest in rectifying social conflicts to build potential friendships with others. Juveniles with CU traits seem to be aware that their aggressive behavior will cause others to suffer, but they do not care when it does.
The symmetric longest queue system

We derive the performance of the exponential symmetric longest queue system from two variants: a longest queue system with Threshold Rejection of jobs and one with Threshold Addition of jobs. It is shown that these two systems provide lower and upper bounds for the performance of the longest queue system. Both variants can be analyzed efficiently. Numerical experiments demonstrate the power of the approach
Epidemiology of Necrotizing Meningoencephalitis in Pug Dogs

Background: Although the histopathologic features of necrotizing meningoencephalitis (NME) have been described previously, little information is available concerning the signalment, geographic distribution, seasonal onset, treatment, and survival of affected dogs. Animals: Sixty Pugs with NME and 14 contemporaneous control Pugs with other intracranial diseases (non‐NME group). Methods: Pugs that were euthanized or died because of intracranial disease were prospectively obtained. All dogs had necropsy, histopathology, and testing for various infectious diseases and were subsequently divided into NME and non‐NME groups. Signalment, geographic distribution, seasonal onset, treatment, and survival were compared between groups. Results: In Pugs with NME, median age at onset of clinical signs was 18 months (range, 4–113 months). A greater proportion of female dogs were present in the NME group (40/60) compared with the control group (6/14). Pugs with NME had a significantly lower mean weight (7.81 kg) than control Pugs (9.79 kg) (P= .012). Mean survival in Pugs with NME was 93 days (range, 1–680 days), with dogs receiving any form of treatment living significantly longer than those that were not treated (P= .003). Anticonvulsive drugs were the only treatment significantly associated with longer survival (P= .003). Conclusions and Clinical Importance: NME appears to be a common cause of intracranial signs in Pugs, based on the high proportion of NME dogs reported in this population. Pugs with NME are most commonly young adult female dogs. Although further investigation is needed to determine the optimal treatment of NME, anticonvulsive drugs appear to beneficially affect duration of survival.
The donut hole

My eldest son, Matthew, nicknamed him “The Dunker. ” Carefully slipping his finger through the donut hole, he would dunk the donut into his ice-cube-chilled coffee, lean carefully over the cup and slide the soggy donut edge into his mouth. Such was the morning ritual of my grandfather John Lapp, a.k. a. “The Dunker. ” Of course, the donut hole was of paramount importance to the process. While it was possible to do with stick donuts, the hole made the procedure far easier, and much more elegant. What, you may ask, do donuts have to do with interventional cardiology? I propose that, as it was to my grandfather, the donut hole is critical to our rituals as well. For nearly fifteen years I have worked with intravascular ultrasound (IVUS); of course displayed in “donut” format with the hole for blood flow in the center surrounded by the fat-ladened rim of plaque. For equally as long, I have struggled to teach new users that while their eyes are drawn to the abundant plaque, what is actually more important is the hole within. “We treat narrowed lumens, not plaque” I repeatedly insist. I recently attended an international congress on coronary physiology. I was gratified that over 200 of my colleagues sat expectantly in an auditorium for two days to learn the intricacies of physiologic measurements performed in the cath lab. I felt a sense of deja vu. Some of my earliest manuscripts written as a cardiology fellow dealt with the impact of intervention (PCI) on coronary physiology [1,2]. I don’t think it is coincidence that my latest abstract (albeit using different methodology) dealt with the same topic [3]. This should not surprise me. While our tools have changed, our reason for doing PCI has not: narrowed lumens restrict blood flow and cause symptoms – we fix narrowed lumens and relieve symptoms. Quite a simple concept, but one which should not be forgotten. I am old enough to have had the honor to meet Andreas Gruentzig on several occasions. You may recall that one of his axioms was that you don’t do PTCA without objective evidence of ischemia. Somewhere along the way we have forgotten this basic principle. The occulo-stenotic reflex has become well developed. In
Distinct roles of visual, parietal, and frontal motor cortices in memory-guided sensorimotor decisions

Mapping specific sensory features to future motor actions is a crucial capability of mammalian nervous systems. We investigated the role of visual (V1), posterior parietal (PPC), and frontal motor (fMC) cortices for sensorimotor mapping in mice during performance of a memory-guided visual discrimination task. Large-scale calcium imaging revealed that V1, PPC, and fMC neurons exhibited heterogeneous responses spanning all task epochs (stimulus, delay, response). Population analyses demonstrated unique encoding of stimulus identity and behavioral choice information across regions, with V1 encoding stimulus, fMC encoding choice even early in the trial, and PPC multiplexing the two variables. Optogenetic inhibition during behavior revealed that all regions were necessary during the stimulus epoch, but only fMC was required during the delay and response epochs. Stimulus identity can thus be rapidly transformed into behavioral choice, requiring V1, PPC, and fMC during the transformation period, but only fMC for maintaining the choice in memory prior to execution. DOI: http://dx.doi. org/10.7554/eLife.13764. 001
Public Leadership in Times of Crisis: Mission Impossible?

Crisis management (prevention, preparedness, response, and reconstruction) is a tough task for political and bureaucratic leaders. This article documents the persistent tensions between the expectations and realities of crisis leadership. It explores the popular notion that crises provide key opportunities for reform. The very occurrence of a crisis is then thought to expose the status quo as problematic, making it easier to gain momentum for alternative policies and institutions. We argue that the opportunities for reform in the wake of crisis are smaller than often thought. The prime reason is that the requisites of crisis leadership are at odds with the requirements of effective reform.
Age-Dependent Consequences of Seizures and the Development of Temporal Lobe Epilepsy in the Rat

The age-related functional changes underlying epileptogenesis remain to be clarified. In the present study, we explored the correlation between metabolic changes, neuronal damage and epileptogenesis during the acute, silent and chronic phases following status epilepticus (SE) induced by lithium-pilocarpine (Li-Pilo) in 10- (P10), 21-day-old (P21) and adult rats. Local cerebral metabolic rates for glucose (LCMRglcs) were measured by the [14C]2-deoxyglucose method during SE, the silent period and the interictal phase of the chronic period. Neurodegeneration was assessed by cresyl violet staining. During SE, LCMRglcs dramatically increased at all ages mainly in forebrain vulnerable regions. During the silent phase, in P21 and adult rats, metabolic decreases were recorded in damaged forebrain regions involved in the genesis and propagation of seizures 14 days after SE. At the end of the silent phase, P21 and adult rats exhibited metabolic increases in intact brainstem areas involved in the remote control of epilepsy. During the interictal phase of the chronic period, LCMRglcs decreased in damaged forebrain areas of adult and P21 rats that were not spontaneously epileptic, while LCMRglcs were similar to control levels in epileptic P21 rats. In P10 rats, there was no damage and no metabolic consequences at any time after SE. In conclusion, the process of epileptogenesis and its functional consequences differ in P21 and adult rats. The factors underlying these age-related differences remain to be explored.