Miracle-dz/UniFAR-FTUs huggingface dataset:
Studies of Advanced Stages of Meditation in the Tibetan Buddhist and Vedic Traditions. I: A Comparison of General Changes

This article is the first of two comparing findings of studies of advanced practitioners of Tibetan Buddhist meditation in remote regions of the Himalayas, with established results on long-term practitioners of the Transcendental Meditation programs. Many parallel levels of improvement were found, in sensory acuity, perceptual style and cognitive function, indicating stabilization of aspects of attentional awareness. Together with observed increases in EEG coherence and aspects of brain function, such changes are consistent with growth towards a state of total brain functioning, i.e. development of full mental potential. They are usually accompanied by improved health parameters. How they may be seen to be consistent with growth of enlightenment will be the subject of a second article.
Impulse differential inclusions: a viability approach to hybrid systems

Impulse differential inclusions are introduced as a framework for modeling hybrid phenomena. Connections to standard problems in the area of hybrid systems are discussed. Conditions are derived that allow one to determine whether a set of states is viable or invariant under the action of an impulse differential inclusion. For sets that violate these conditions, methods are developed for approximating their viability and invariance kernels, that is the largest subset that is viable or invariant under the action of the impulse differential inclusion. The results are demonstrated on examples.
Iterative Learning of Relation Patterns for Market Analysis with UIMA

Monitoring news as well as corporate and community web sites is a important task in market analysis. Yet, it requires much manual processing and is inherently incomplete as only a small fraction of the data produced on the Web can be processed by human analysts. We present here our ongoing efforts to employ UIMA annotations and search on UIMA-annotated documents for supporting market analysis. Information is extracted based on relation patterns that serve as queries. The results are then visualized to allow detailed market analysis. The current status of the reported work is that we are already implemented most of the required infrastructure (UIMA, Pronto, Omni nd) and started some of the outlined experiments. The Unstructured Information Management Architecture (UIMA) is a framework that enables a component-based analysis of unstructured documents(Ferrucci and Lally, 2004) providing a typed data structure for the derived structured information as well as means for de ning and controlling process ows. We have developed Pronto, a system for automatic learning of text patterns for extracting instances of semantic relations(Blohm and Cimiano, 2006). The system essentially uses the Web as a corpus accessing it via a Web search engine. Patterns are learned by abstraction over the textual occurrences of relation instances in the corpus. In the experiments we employ Pronto to produce UIMA annotations and additionally feed the UIMA annotation structure into the learning process to be able to learn structural patterns rather than plain text patterns. They will enable our system to annotated mentions of salient relations for market analysis. The output will allow retrieving facts about market events using structured queries.
Case study illustrations of a scorecard to measure IT strategy improvements in UK SMEs

Purpose – The purpose of this paper is to demonstrate a means of measuring information technology (IT) strategy improvements in small to medium‐sized enterprises (SMEs). Design/methodology/approach – A longitudinal study of eight SMEs was carried out over a two‐year period, applying an IT development scorecard which uses a Likert scale to measure changes during the study period.Findings – The paper finds that seven of the eight companies assessed during the period of the study showed improvements in their IT development, with only one company showing negligible improvement. The company that made negligible improvement went into receivership 12 months after completion of the study.Research limitations/implications – The key limitations were that only eight companies were prepared to participate fully in the study, and the diversity of type of company was large. Future research should include a larger sample size and use of companies from within the same industry/sector.Practical implications – The scorecard.
Predictors of Substance Use Latent Classes Among American Indian Youth Attending Schools On or Near Reservations.

BACKGROUND AND OBJECTIVES Identical latent classes of substance use for 7 to 8 grade and 9 to 12 grade American Indian (AI) youth living on or near reservations suggest that patterns of substance use are established early among these youth. This study examines relationships of substance-related factors to latent class membership and whether these relationships differ by grade group. METHODS In-school surveys were administered to 1503 7 to 8 grade and 1995 9 to 12 grade students from 46 schools on or near reservations during the 2009/2010 to 2012/2013 school years. Four-class latent class models of substance use were specified and five classes of substance-related factors (peers, substance availability, perceived harm, family, early initiation), plus grade level and gender, were evaluated as predictors. RESULTS For 7 to 8 grade students, substance-related factors differentiated nonusers from users, while for 9 to 12 graders, these factors also differentiated types of users. Early initiation and peer factors were strongly related to class membership, while other factors were less strongly related. DISCUSSION AND CONCLUSIONS Early initiation of alcohol or marijuana is strongly related to being in a substance-using class for AI youth. Because these youth tend to initiate use earlier that other US youth, prevention resources should be targeted to reaching them and their families before age 12. SCIENTIFIC SIGNIFICANCE Predictors of latent classes of substance use were identified for reservation-based AI youth. While the classes were identical for 7 to 8 grade and 9 to 12 grade youth, predictors varied across grade group, which may inform how best to develop prevention efforts unique to middle and high school AI youth.
Walking for the Assessment of Balance in Healthy Subjects Older than 40 Years

Background: The Berg scale and the timed ‘up and go’ test (TUG) are established measures to assess mobility in frail older adults. As an alternative to self-paced tests to assess aerobic exercise capacity, the incremental shuttle walk test (ISWT) was developed. We hypothesized that ISWT may be useful for the assessment of aerobic capacity and balance simultaneously in healthy adults. Objectives: There are 3 objectives: (1) to evaluate the intra-tester reliability of TUG in healthy subjects; (2) to compare the validity of TUG, ISWT and comfortable gait speed (GS) to evaluate balance assessed by the Berg balance scale, and (3) to evaluate the correlations among these walking tests. Methods: We studied a sample of 64 subjects (82.81% women) aged 40–84 years to assess the intra-tester reliability of TUG. Of these, 21 subjects also performed ISWT, GS and the Berg balance scale. We also assessed height, weight, body mass index, spirometry and reported physical activity. Results: The average time to complete TUG was 7.23 ± 1.27 s. The interclass correlation coefficient of TUG was excellent (0.936; 95% CI: 0.895–0.961). Age (r = 0.36), GS (r = –0.64), GS/height (r = –0.44), ISWT (r = –0.65) and the Berg score (r = –0.65) were correlated with TUG (p < 0.05). The Berg score was significantly (p < 0.05) correlated with GS (r = 0.61) and ISWT (r = 0.61). Moreover, ISWT was mutually related with GS (r = 0.68). We evaluated 2 models of linear regression, using GS and TUG as independent variables in each of them. In the 1st model, GS described 47% of the ISWT variability. In the 2nd, TUG described 42.7% of the ISWT variability. Conclusions: The capacity of walking is related to balance in healthy adults and seniors. Our results suggest the usefulness of ISWT as a new tool for the simultaneous evaluation of the aerobic capacity and balance in healthy subjects. An important part of the ISWT variation was explained by GS and TUG. Secondly, we confirmed the significant influence of age in the TUG performance and the excellent reliability of this field walking test.
Oncogenesis of RON receptor tyrosine kinase: a molecular target for malignant epithelial cancers

AbstractRecepteur d'origine nantais (RON) belongs to a subfamily of receptor tyrosine kinases (RTK) with unique expression patterns and biological activities. RON is activated by a serum-derived growth factor macrophage stimulating protein (MSP). The RON gene transcription is essential for embryonic development and critical in regulating certain physiological processes. Recent studies have indicated that altered RON expression contributes significantly to cancer progression and malignancy. In primary tumors, such as colon and breast cancers, overexpression of RON exists in large numbers and is often accompanied by the generation of different splicing variants. These RON variants direct a unique program that controls cell transformation, growth, migration, and invasion, indicating that altered RON expression has the ability to regulate motile/invasive phenotypes. These activities were also seen in transgenic mice, in which targeted expression of RON in lung epithelial cells resulted in numerous tumors with pathological features of human bronchioloalveolar carcinoma. Thus, abnormal RON activation is a pathogenic factor that transduces oncogenic signals leading to uncontrolled cell growth and subsequent malignant transformation. Considering these facts, RON and its variants can be considered as potential targets for therapeutic intervention. Experiments using small interfering RNA and neutralizing monoclonal antibodies demonstrated that suppressing RON expression and activation decreases cancer cell proliferation, increases apoptotic death, prevents tumor formation in nude mice, and reduces malignant phenotypes. Thus, blocking RON expression and activation has clinical significance in reversing malignant phenotypes and controlling tumor growth.
Risk of Melanoma Recurrence After Diagnosis of a High-Risk Primary Tumor.

Importance With emerging new systemic treatments for metastatic melanoma, early detection of disease recurrence is increasingly important. Objective To investigate the risk of melanoma recurrence in patients with a localized melanoma at a high risk of metastasis. Design, Setting, and Participants A total of 1254 patients with newly diagnosed, histologically confirmed tumor category T1b to T4b melanoma in Queensland, Australia, were recruited prospectively between October 1, 2010, and October 1, 2014, for participation in a cohort study. Data analysis was conducted from February 8, 2018, to February 20, 2019. We used Cox proportional hazards regression analysis to examine associations between patient and tumor factors and melanoma recurrence. Exposures Disease-free survival (DFS) by melanoma tumor category defined by the 7th vs 8th editions of the AJCC Cancer Staging Manual (AJCC 7 vs AJCC 8). Main Outcomes and Measures Melanoma recurrences were self-reported through follow-up questionnaires administered every 6 months and confirmed by histologic or imaging findings. Results Of 1254 patients recruited, 825 individuals (65.8%) agreed to participate. Thirty-six were found to be ineligible after providing consent and a further 89 patients were excluded after reclassifying tumors using AJCC 8, leaving 700 participants with high-risk primary melanoma (mean [SD] age, 62.2 [13.5] years; 410 [58.6%] men). Independent predictors of recurrence were head or neck site of primary tumor, ulceration, thickness, and mitotic rate greater than 3/mm2 (hazard ratio, 2.36; 95% CI, 1.19-4.71). Ninety-four patients (13.4%) developed a recurrence within 2 years of diagnosis: 66 tumors (70.2%) were locoregional, and 28 tumors (29.8%) developed at distant sites. After surgery for locoregional disease, 37 of 64 patients (57.8%) remained disease free at 2 years, 7 patients (10.9%) developed new locoregional recurrence, and 20 patients (31.3%), developed distant disease. Two-year DFS was similar when comparing AJCC 7 and AJCC 8, for T1b (AJCC 7, 253 [93.3% DFS]; AJCC 8, 242 [93.0% DFS]) and T4b (AJCC 7 and AJCC 8, 50 [68.0% DFS] category tumors in both editions. Patients with T2a to T4a tumors who did not have a sentinel lymph node biopsy (SLNB) at diagnosis had lower DFS than patients with the same tumor category and a negative SLNB (T2a: 136 [91.1%; 95% CI, 86.4-95.9] vs 96 [96.9%; 95 % CI, 93.4-100.0]; T4a: 33 [78.8%; 95% CI, 64.8-92.7] vs 6 [83.3; 95% CI, 53.5-100.0]). Conclusions and Relevance These findings suggest that 13.4% of patients with a high-risk primary melanoma will experience disease recurrence within 2 years. Head or neck location of initial tumor, SLNB positivity, and signs of rapid tumor growth may be associated with primary melanoma recurrence.
Multiple 3D Object Recognition using RGB-D Data and Physical Consistency for Automated Warehousing Robots

In this research, we propose a method to recognize multiple objects in the shelves of automated warehouses. The purpose of this research is to enhance the reliability of the Hypothesis Verification (HV) method that simultaneously recognizes layout of multiple objects. The proposed method have employed not only the RGB-D consistency between the input scene and the scene hypothesis but also the physical consistency. By considering the physical consistency of the scene hypothesis, the proposed HV method can efficiently reject false one. Experiment results for object which are used at Amazon Picking Challenge 2015 have been confirmed that the recognition success rate of the proposed method is higher than the previous HV method.
Large deflection micromechanical scanning mirrors for linear scans and pattern generation

An electrostatically driven silicon micro scanning mirror (MSM) for one-dimensional (1-D) and two-dimensional (2-D) deflection of light is presented. A special configuration of the driving electrodes allows the use of small electrode gaps without restricting the deflection of the plate geometrically. In this paper, the starting of the oscillation and the operation of the scanner is discussed. Experimental results show that scan angles of up to 60/spl deg/ can be achieved at a driving voltage of only 20 V. The 2-D deflection of a laser beam is obtained by a gimbal mounting of the mirror plate. For the fabrication of the devices, SOI-wafers are used as the base material. The mechanical structures are defined by a deep silicon etch. For the electrical isolation of areas on the movable frame, polysilicon-filled trenches are used. The mechanical stability of the scanners is tested. The devices resist shocks of more than 1000 g and show no change of the resonance frequency even after long run tests of 7/spl times/10/sup 9/ periods.
RED Theory for QoS Provisioning in Wireless Communications

In this paper, we study the performance limit of a wireless communication system over a fading channel. The system under study consists of 1) a finite-buffer discrete-time queueing system on the link layer, and 2) a rate-adaptive channel coding system on the physical layer. The objective of this paper is to analyze the relationship among data rate (R), packet error probability (E), and delay bound (D), under the interaction between the link layer and the physical layer. In our analysis, we consider three types of packet errors, i.e., 1) packet drop due to full buffer, 2) packet drop due to delay bound violation, and 3) packet decoding error due to channel noise. We obtain an upper bound on the packet error probability. Furthermore, by minimizing the packet error probability over the transmission rate, we obtain an optimal rate control policy that guarantees the user-specified data rate and delay bound. In the case of constant arrival, the optimal rate control policy results in an RED triplet; then by varying data rate and delay bound, we obtain RED Pareto-optimal surface, which serves as the performance limit of the system under study.
A congruent solution to arthropod phylogeny: phylogenomics, microRNAs and morphology support monophyletic Mandibulata

While a unique origin of the euarthropods is well established, relationships between the four euarthropod classes—chelicerates, myriapods, crustaceans and hexapods—are less clear. Unsolved questions include the position of myriapods, the monophyletic origin of chelicerates, and the validity of the close relationship of euarthropods to tardigrades and onychophorans. Morphology predicts that myriapods, insects and crustaceans form a monophyletic group, the Mandibulata, which has been contradicted by many molecular studies that support an alternative Myriochelata hypothesis (Myriapoda plus Chelicerata). Because of the conflicting insights from published molecular datasets, evidence from nuclear-coding genes needs corroboration from independent data to define the relationships among major nodes in the euarthropod tree. Here, we address this issue by analysing two independent molecular datasets: a phylogenomic dataset of 198 protein-coding genes including new sequences for myriapods, and novel microRNA complements sampled from all major arthropod lineages. Our phylogenomic analyses strongly support Mandibulata, and show that Myriochelata is a tree-reconstruction artefact caused by saturation and long-branch attraction. The analysis of the microRNA dataset corroborates the Mandibulata, showing that the microRNAs miR-965 and miR-282 are present and expressed in all mandibulate species sampled, but not in the chelicerates. Mandibulata is further supported by the phylogenetic analysis of a comprehensive morphological dataset covering living and fossil arthropods, and including recently proposed, putative apomorphies of Myriochelata. Our phylogenomic analyses also provide strong support for the inclusion of pycnogonids in a monophyletic Chelicerata, a paraphyletic Cycloneuralia, and a common origin of Arthropoda (tardigrades, onychophorans and arthropods), suggesting that previous phylogenies grouping tardigrades and nematodes may also have been subject to tree-reconstruction artefacts.
Interaction of Specialized Cardiac Conduction System With Antiarrhythmic Drugs: A Simulation Study

The use of antiarrhythmic drugs is common to treat heart rhythm disorders. Computational modeling and simulation are promising tools that could be used to investigate the effects of specific drugs on cardiac electrophysiology. In this paper, we study the multiscale effects of dofetilide, a drug that blocks IKr, from cellular to organ level paying special attention to its effect on heart structures, in particular the specialized cardiac conduction system (CCS). We include a model of the CCS in a patient-specific anatomical ventricular model and study the drug effects in simulations with and without a CCS. Results confirmed the expected effects of dofetilide at cellular level, increasing the action potential duration, and at organ level, prolonging the QT segment. Notable differences are shown between models with and without the CCS on action potential duration distributions. These techniques show the importance of heart heterogeneity and the global effects of the interaction of drugs with cardiac structures.
Randomized, Double-Blind Clinical Trial to Assess the Acute Diuretic Effect of Equisetum arvense (Field Horsetail) in Healthy Volunteers

In this double-blind, randomized clinical trial, 36 healthy male volunteers were randomly distributed into three groups (n = 12) that underwent a three-step treatment. For four consecutive days, we alternately administered a standardized dried extract of Equisetum arvense (EADE, 900 mg/day), placebo (corn starch, 900 mg/day), or hydrochlorothiazide (25 mg/day), separated by a 10-day washout period. Each volunteer served as his own control, and the groups' results were compared. We repeated the same evaluation after each stage of treatment to evaluate the safety of the drug. The diuretic effect of EADE was assessed by monitoring the volunteers' water balance over a 24 h period. The E. arvense extract produced a diuretic effect that was stronger than that of the negative control and was equivalent to that of hydrochlorothiazide without causing significant changes in the elimination of electrolytes. There was no significant increase in the urinary elimination of catabolites. Rare minor adverse events were reported. The clinical examinations and laboratory tests showed no changes before or after the experiment, suggesting that the drug is safe for acute use. Further research is needed to better clarify the mechanism of diuretic action and the other possible pharmacological actions of this phytomedicine.
Concurrent validation of estimated activity energy expenditure using a 3‐day diary and accelerometry in adolescents

Estimates of daily energy expenditure are important to studies of physical activity and energy balance. Objective measures are not always feasible and further research is needed to validate survey instruments and diaries. The study validates estimated activity energy expenditure (AEE) based on a 3‐day diary protocol relative to AEE derived from uniaxial accelerometry in adolescents, 265 girls and 227 boys (12.5–16.4 years). Participants completed the diary and wore a GT1M Actigraph accelerometer on the same days. Height and weight were measured. Correlations between protocols were significant (P<0.001) but moderate, r=0.65 in males and r=0.69 in females. The highest correlation occurred among males on Friday, r=0.74 (P<0.01). Controlling for body mass, partial correlations between protocols decreased to 0.44 and 0.35 in males and females, respectively. About 97% of the cases fell within the limits of agreement in a Bland–Altman plot. The criterion of inclusion for the accelerometer excluded 18% of the initial sample. In summary, the 3‐day diary was completed without any major problems and provided a reasonably valid alternative for assessing AEE. Concordance between methods was slightly lower for individuals with higher values of AEE.
GrDHP: A General Utility Function Representation for Dual Heuristic Dynamic Programming

A general utility function representation is proposed to provide the required derivable and adjustable utility function for the dual heuristic dynamic programming (DHP) design. Goal representation DHP (GrDHP) is presented with a goal network being on top of the traditional DHP design. This goal network provides a general mapping between the system states and the derivatives of the utility function. With this proposed architecture, we can obtain the required derivatives of the utility function directly from the goal network. In addition, instead of a fixed predefined utility function in literature, we conduct an online learning process for the goal network so that the derivatives of the utility function can be adaptively tuned over time. We provide the control performance of both the proposed GrDHP and the traditional DHP approaches under the same environment and parameter settings. The statistical simulation results and the snapshot of the system variables are presented to demonstrate the improved learning and controlling performance. We also apply both approaches to a power system example to further demonstrate the control capabilities of the GrDHP approach.