Miracle-dz/UniFAR-FTUs huggingface dataset:
Biocompatibility of Dextran-Coated 30 nm and 80 nm Sized SPIONs towards Monocytes, Dendritic Cells and Lymphocytes

Dextran-coated superparamagnetic iron oxide nanoparticles (SPIONDex) of various sizes can be used as contrast agents in magnetic resonance imaging (MRI) of different tissues, e.g., liver or atherosclerotic plaques, after intravenous injection. In previous studies, the blood compatibility and the absence of immunogenicity of SPIONDex was demonstrated. The investigation of the interference of SPIONDex with stimulated immune cell activation is the aim of this study. For this purpose, sterile and endotoxin-free SPIONDex with different hydrodynamic sizes (30 and 80 nm) were investigated for their effect on monocytes, dendritic cells (DC) and lymphocytes in concentrations up to 200 µg/mL, which would be administered for use as an imaging agent. The cells were analyzed using flow cytometry and brightfield microscopy. We found that SPIONDex were hardly taken up by THP-1 monocytes and did not reduce cell viability. In the presence of SPIONDex, the phagocytosis of zymosan and E. coli by THP-1 was dose-dependently reduced. SPIONDex neither induced the maturation of DCs nor interfered with their stimulated maturation. The particles did not induce lymphocyte proliferation or interfere with lymphocyte proliferation after stimulation. Since SPIONDex rapidly distribute via the blood circulation in vivo, high concentrations were only reached locally at the injection site immediately after application and only for a very limited time. Thus, SPIONDex can be considered immune compatible in doses required for use as an MRI contrast agent.
Constraints on heavy decaying dark matter from 570 days of LHAASO observations

The supplemental material is organized as follows. In Sec. I we describe in detail the regions of interest selected in the present analysis. In Sec. II, we describe the γ/hadron separation method. In Sec. III, we detail the method used to compute the detector response from Monte Carlo simulations. In Sec. IV we provide more details on the calculations of the DM signal and quantify the uncertainties related to the density profile choice, the background photons, and the galactic magnetic field. In Sec. V we report the constraints on the lifetime of DM particles for other decay channels. Finally, we compare with the latest IceCube results in Sec. VI.
BEATVIC, a body-oriented resilience therapy for individuals with psychosis: Short term results of a multi-center RCT.

BACKGROUND Individuals with a psychotic disorder are at an increased risk of victimization, but evidenced-based interventions are lacking. AIMS A body-oriented resilience therapy ('BEATVIC') aimed at preventing victimization was developed and its effectiveness was assessed in a multicenter randomized controlled trial. METHODS 105 people with a psychotic disorder were recruited from six mental health centers. Participants were randomly allocated to 20 BEATVIC group sessions (n = 53) or befriending group sessions (n = 52). Short term effects on risk factors for victimization (e.g. social cognitive deficits, inadequate interpersonal behavior, low self-esteem, internalized stigma, aggression regulation problems), physical fitness and secondary outcomes were expected. At six-month follow-up, the effect on victimization (either a 50% reduction or an absence of victimization incidents) was examined. RESULTS Intervention-dropout was 28.30% for BEATVIC and 39.62% for befriending. In both conditions the majority of participants (60.5% BEATVIC vs 62.9% befriending) showed a reduction or absence of victimization incidents at six months follow-up, which was not significantly different according to condition. Multilevel analyses revealed no main effect of time and no significant time x group interaction on other outcome measures. Per protocol analyses (participants attending ≥ 75% of the sessions) did not change these results. CONCLUSIONS Although a reduction or absence of victimization was found at short term follow-up for the majority of participants, BEATVIC was not more effective than the active control condition. No short-term additional effects on risk factors of victimization were found. Analysis of the data at 2-year follow-up is warranted to investigate possible effects in the long-term. TRIAL REGISTRATION NUMBER Current Controlled Trials: ISRCTN21423535.
The correlated radio and optical asymmetries of powerful radio galaxies

We present radio continuum and polarization maps of four «classical double» radio galaxies, overlaid on optical emission-line images. The sources (3C 247, 263.1, 280 and 299) are all small, powerful and distant (with D 10 26.8 W Hz −1 sr −1 , 0.37<z<1.0). In three cases we find that the emission-line gas lies on that side of the radio source for which the depolariztion is stronger, the hotspot closer to the core and the radio spectrum steeper. We discuss the origin of these features, and suggest that a non-symmetrical distribution of gas around the host galaxy could account for the observed asymmetries
Effect of Audio drama based educational program on healthy life style practices among visually impaired students

The visual impairment students need support in personnel activities. Visual impairment students are extremely vulnerable because of limiting access to health information and ability to live a healthy lifestyle. Aim: Study aimed to evaluate the effect of Audio drama based educational program on healthy life style practices among visually impaired students Design: A quasi experimental pre/post-test research design was utilized. Setting: Al-Nour school for the Blind, Kafr El-Sheikh governorate. Sample: A purposive sample of 210 visually impaired students. Tools I: Structured interviewing Questionnaire which consisted of four parts 1. Assess socio-demographic data; 2. Assess medical and family history for students; 3. Questionnaire for assessing student knowledge regards personal hygiene 4. Student satisfaction Questionnaire with the audioeducational sessions. II: Health-Related Lifestyle Questionnaire to assess the student life style. Results: There were diminish of visually impairment students' knowledge and practices regarding personal hygiene and healthy lifestyle before implementing the Audio drama sessions. In addition, there were an enhancement in students' total knowledge and practices scores post provision the Audio-drama teaching sessions with highly statistically significant differences at P<0.01. Conclusion: The Audio drama educational sessions were effective in improvement the visually impaired students' knowledge and practices regarding Lifestyle. Recommendation: Raising awareness of students about the personal hygiene and healthy lifestyle by further educational and training programs especially for disable and visual impairment students.
A Direct Approximation of Cole-Cole-Systems for Time-Domain Analysis

Cole-Cole-systems are important in electrochemistry to represent impedances of galvanic elements like fuel cells. Fractional calculus has to be applied for system analysis of Cole-Cole-systems in the time-domain. The representation of fractional differential equations of Cole-Cole-systems is addressed in this contribution. Usually, the fractional derivation is approximated, to ensure that the fractional system can be represented by conventional differential equations of an integer order. This article presents a new opposite approach, which results by direct approximation of the Cole-Cole-systems by conventional linear time invariant systems. The method considered is based on the distribution density function of relaxation times of first order Debye-processes. This distribution density is an alternative representation of the transfer behavior of such a system. Several approximation methods, based on an analysis of the distribution density, are presented in this work. The feasibility of these methods will be demonstrated by a comparison of simulated data of the approximation models to ideal data and reference values, respectively.Copyright © 2005 by ASME
Focusing flexural Lamb waves by designing elastic metamaterials bonded on a plate

In this paper, a method to focus flexural Lamb waves to a local area by mounting elastic metamaterials (EMMs) on the surface of the plate is proposed. The EMM consists of silicon rubber and lead connected in series bonded vertically on an aluminum plate. A simplified effective mass-“spring”-mass model is used to study the EMM plate. The frequency-dependent effective mass density of the EMM plate is determined with the aid of the numerically based effective medium method. By making use of the low locally resonant frequency of the EMM plate, the EMM plate is carefully designed with different dimensions to attain high effective mass densities. The effective mass density can be assumed to dominate the change of wave velocity and propagation direction in the EMM plate. An effective mass density profile is then employed along the transverse direction of wave propagation to achieve focusing. Finally, numerical simulation with finite element method (FEM) is utilized to investigate the focusing phenomenon of the A0 mode Lamb waves at 30 kHz and the out-of-plane displacement response beyond the EMM region. Numerical simulation results have shown that focusing the low frequency A0 mode Lamb waves using EMMs is feasible. The focusing may have potential applications in structural health monitoring by manipulating Lamb waves through controlling and focusing Lamb waves to any arbitrary location of the plate with amplified displacement and yet largely retained five-peaked toneburst waveform.
ISMAILIA2: A Newly Released High Yielding Peanut Cultivar for New Reclaimed Land

: Ismailia 2, a new peanut cultivar released by Oil Crop Research Department, Field Crops Research Institute, ARC, Egypt in 2020, offers peanut growers a new choice for high yielding, and high seed oil percentage cultivar. Yield trials conducted during three successive growing summer seasons of 2016, 2017 and 2018 and 10 verification yield trials through the two growing seasons of 2019 and 2020. The results proved the superiority of the new cultivar Ismailia 2 over the commercial peanut cultivars
A Joint and Seamless Compensation of Close-In and Reciprocal Mixing Phase Noise Distortion

The phase noise (PN) distortion represents a major source of performance degradation in modern receivers. The phase noise distorts the desired signal via two mechanisms. In the first, the desired signal is distorted primarily by the phase noise spectrum near the carrier frequency. An extensive body of literature exists in compensating for this close-in phase noise distortion, most of which rely on the use of known pilot signals. The other mechanism is the outer skirts of the phase noise spectrum corrupting the desired signal via reciprocal mixing of interfering blockers. There is very little work on compensating for the effects of reciprocal mixing with no practical solution to date. This article presents an approach to jointly and seamlessly compensate for both close-in and reciprocal mixing phase noise distortion. The proposed approach makes no assumptions on the received signal spectrum, the availability of pilot tones, the phase noise spectrum, or knowledge of the dominant blockers. The proposed approach is analyzed and compared with the conventional receiver. Simulation results are presented to validate the analysis as well as to provide greater insights. Measurement results of a prototype receiver show over 10 dB improvement compared to a conventional receiver.
Local anodic oxidation of superconducting NbN thin films by an atomic force microscope

A local anodic oxidation technique has been applied to create oxidized nanowires on superconducting NbN thin films using an atomic force microscope (AFM) with a conductive probe. The AFM surface topography shows that both the width and height of the oxidized nanowires increase with increasing applied probe voltage under a certain relative humidity and a probe scan rate. The resistances of the NbN microbridges with and without an oxidized nanowire crossing were measured, and the results indicate that the oxidized nanowires with height of more than 8 nm are fully oxidized. The R–T and I–V characteristics of the NbN microbridges with the oxide wire of less than 8 nm were also obtained and analyzed. Methods for fabricating devices such as superconducting single photon detectors and superconducting hot electron bolometer mixers using this technology are discussed.
Voltage controlled modification of flux closure domains in planar magnetic structures for microwave applications

Voltage controlled modification of the magnetocrystalline anisotropy in a hybrid piezoelectric/ferromagnet device has been studied using Photoemission Electron Microscopy with X-ray magnetic circular dichroism as the contrast mechanism. The experimental results demonstrate that the large magnetostriction of the epitaxial Fe81Ga19 layer enables significant modification of the domain pattern in laterally confined disc structures. In addition, micromagnetic simulations demonstrate that the strain induced modification of the magnetic anisotropy allows for voltage tuneability of the natural resonance of both the confined spin wave modes and the vortex motion. These results demonstrate the possibility for using voltage induced strain in low-power voltage tuneable magnetic microwave oscillators.
Cycle Frames of Complete Multipartite Multigraphs ‐ III

For two graphs G and H their wreath product G⊗H has vertex set V(G)×V(H) in which two vertices (g1,h1) and (g2,h2) are adjacent whenever g1g2∈E(G) or g1=g2 and h1h2∈E(H) . Clearly, Km⊗In , where In is an independent set on n vertices, is isomorphic to the complete m‐partite graph in which each partite set has exactly n vertices. A 2‐regular subgraph of the complete multipartite graph Km⊗In containing vertices of all but one partite set is called partial 2‐factor. For an integer λ, G(λ) denotes a graph G with uniform edge multiplicity λ. Let J be a set of integers. If (Km⊗In)(λ) can be partitioned into edge‐disjoint partial 2‐factors consisting cycles of lengths from J, then we say that (Km⊗In)(λ) has a (J,λ)‐cycle frame. In this paper, we show that for m≥3 and k≥2 , there exists a (2k,λ) ‐cycle frame of (Km⊗In)(λ) if and only if (m−1)n≡0(mod2k) and λn≡0(mod2) . In fact our results completely solve the existence of a (2k,λ) ‐cycle frame of (Km⊗In)(λ) .
A probabilistic framework for product health monitoring in multistage manufacturing using Unsupervised Artificial Neural Networks and Gaussian Processes

The emergence of highly instrumented manufacturing systems has enabled the paradigm of smart manufacturing that provides high levels of prognostics functionality. Of particular interest is to precisely determine geometric conformance or non-conformance of workpieces during manufacturing. This paper presents a new dimensional product health monitoring system that learns from in-process sensor data and updates the prediction of the product quality as the product is manufactured. The system uses data from multiple manufacturing stages, unlike from a single stage at a time, to predict the dimensional quality of the finished product that is updated with subsequent measurements such as On-Machine Measurements (OMMs), in on-line incremental learning fashion. It is based on self-supervised neural networks for dimensionality reduction, Gaussian Process Regression (GPR) models for probabilistic prediction about the end product condition and the associated uncertainty, and Bayesian information fusion for updating the conditional probability distribution of the end product quality in the light of new information. The monitoring approach was tested on the prediction of diameter deviations with validation results showing its ability to achieve an average accuracy better than 5 μm in terms of the Root Mean Squared Error (RMSE). Having obtained a Probability Density Function (PDF) for the measurand of interest, the conformance and non-conformance probabilities given the tolerance specifications are computed to support the principle of inspection by exception. This ability to construct a conformance probability-based product quality monitoring system using probabilistic machine learning methods constitute a step change to manufacturing prognostics.
Wave–current interaction at an angle 2: theory By PRADEEP C. FERNANDO, PENGZHI LIN and JUNKE GUO, Journal of Hydraulic Research, Vol. 49, No. 4 (2011), pp. 437–449

The Authors present a new model for the effect of waves on current profiles and conclude among others that “the flow properties are insensitive to the interaction angle φ′′. This strongly disagrees with the experimental evidence from Kemp and Simons (1982, 1983) as discussed by Nielsen (1992). These experiments indicate that the apparent roughness increase due to the waves is much stronger for opposing (φ = 180◦) than for following waves at φ = 0◦. The Authors’ model is indifferent to φ = 180◦ versus φ = 0◦. Correspondingly, the Authors ignore the spectacular current profile data sets by Klopman (1994), which also indicate strong qualitative differences for opposing versus following currents (e.g. Figure 1 of Groeneweg and Battjes 2003). These data sets were subsequently (at least for weak currents) modelled analytically by Nielsen and You (1996) and by Groeneweg and Klopman (1998), indicating two different analytical reasons for the qualitative difference between the current profiles for weak following versus opposing currents (Groeneweg and Battjes 2003). The model by Nielsen and You (1996) relies on the “wave Reynolds stress −ρũw̃, which drives boundary layer streaming under progressive waves. For stronger currents, their simple analytical model had to be amended in an ad hoc fashion to account for nonlinear wave–current interactions. These are, however, easily modelled with ũw̃-resolving 2-dimensional (one horizontal and the vertical) numerical models. In short, the effects of the wave Reynolds stress on the current, which are opposite for opposing versus following currents, cannot be ignored except perhaps for perpendicular currents. The Authors should extend their discussion to include the above mentioned data sets bearing clear evidence to this issue.
Experimental Life History Evolution Results in Sex-specific Evolution of Gene Expression in Seed Beetles

Abstract The patterns of reproductive timing and senescence vary within and across species owing to differences in reproductive strategies, but our understanding of the molecular underpinnings of such variation is incomplete. This is perhaps particularly true for sex differences. We investigated the evolution of sex-specific gene expression associated with life history divergence in replicated populations of the seed beetle Acanthoscelides obtectus, experimentally evolving under (E)arly or (L)ate life reproduction for >200 generations which has resulted in strongly divergent life histories. We detected 1,646 genes that were differentially expressed in E and L lines, consistent with a highly polygenic basis of life history evolution. Only 30% of differentially expressed genes were similarly affected in males and females. The evolution of long life was associated with significantly reduced sex differences in expression, especially in non-reproductive tissues. The expression differences were overall more pronounced in females, in accordance with their greater phenotypic divergence in lifespan. Functional enrichment analysis revealed differences between E and L beetles in gene categories previously implicated in aging, such as mitochondrial function and defense response. The results show that divergent life history evolution can be associated with profound changes in gene expression that alter the transcriptome in a sex-specific way, highlighting the importance of understanding the mechanisms of aging in each sex.
Could machine learning approach improve diagnosis accuracy for malignancy in imaging examinations? A mini-review

The early diagnosis of malignancy by ultrasound, Computed Tomography (CT), and Magnetic Resonance Imaging (MRI) is still limited. Therefore, the diagnostic efficacy could be improved from Machine Learning (ML), which mainly based on deep learning and convolutional neural networks. In this work, we reviewed ML-based imaging examinations ultrasound, CT and MRI could evaluate early diagnosis value of small size tumor. Besides, ultrasound could distinguish primary tumors from metastatic tumors, CT could also play a role in tumor risk classification, and MRI could also predict the pathological grade and enzyme mutation status of malignancy, which can be used to predict early survival and guide clinical decision-making. Therefore, we believe that ML could be added to improve the accuracy of diagnosis in patients with suspected tumor imaging examinations.
Expanding the Functionality of an Autoinduction Device for Repression of Gene Expression in Bacillus subtilis

Autonomous control of gene expression through engineered quorum-sensing processes is broadly applicable to biosynthetic pathways, including simultaneous control of different genes. It is also a powerful tool for balancing growth and production. We had previously engineered a modular autoinduction device for the control of gene expression in B. subtilis. Now, we expand its functionality to repress gene expression autonomously. The engineered R8 promoter responds to AHL accumulation in the culture medium. In a riboflavin-producing strain, the AHL-Lux complex exerts 5-fold repression on the R8-driven expression of the flavokinase/FAD synthetase gene ribC, resulting in a higher titer of the vitamin. We engineered a strain able to autonomously induce and repress different genes simultaneously, demonstrating the potential of the device for use in metabolic engineering.
Mesenchymal Stem Cells in Radiation-Induced Pulmonary Fibrosis: Future Prospects

Radiation-induced pulmonary fibrosis (RIPF) is a general and fatal side effect of radiotherapy, while the pathogenesis has not been entirely understood yet. By now, there is still no effective clinical intervention available for treatment of RIPF. Recent studies revealed mesenchymal stromal cells (MSCs) as a promising therapy treatment due to their homing and differentiation ability, paracrine effects, immunomodulatory effects, and MSCs-derived exosomes. Nevertheless, problems and challenges in applying MSCs still need to be taken seriously. Herein, we reviewed the mechanisms and challenges in the applications of MSCs in treating RIPF.
Multi-level Discourse Analysis in a Physics Teaching Methods Course from the Psychological Perspective of Activity Theory

In this paper, we present and apply a multi-level method for discourse analysis in science classrooms. This method is based on the structure of human activity (activity, actions, and operations) and it was applied to study a pre-service physics teacher methods course. We argue that such an approach, based on a cultural psychological perspective, affords opportunities for analysts to perform a theoretically based detailed analysis of discourse events. Along with the presentation of analysis, we show and discuss how the articulation of different levels offers interpretative criteria for analyzing instructional conversations. We synthesize the results into a model for a teacher's practice and discuss the implications and possibilities of this approach for the field of discourse analysis in science classrooms. Finally, we reflect on how the development of teachers' understanding of their activity structures can contribute to forms of progressive discourse of science education.