Miracle-dz/UniFAR-FTUs huggingface dataset:
Baseline Susceptibility of Field Populations of Helicoverpa armigera to Bacillus thuringiensis Vip3Aa Toxin and Lack of Cross-Resistance between Vip3Aa and Cry Toxins

The cotton bollworm Helicoverpa armigera (Hübner) is one of the most damaging cotton pests worldwide. In China, control of this pest has been dependent on transgenic cotton producing a single Bacillus thuringiensis (Bt) protein Cry1Ac since 1997. A small, but significant, increase in H. armigera resistance to Cry1Ac was detected in field populations from Northern China. Since Vip3Aa has a different structure and mode of action than Cry proteins, Bt cotton pyramids containing Vip3Aa are considered as ideal successors of Cry1Ac cotton in China. In this study, baseline susceptibility of H. armigera to Vip3Aa was evaluated in geographic field populations collected in 2014 from major cotton-producing areas of China. The LC50 values of 12 field populations ranged from 0.053 to 1.311 μg/cm2, representing a 25-fold range of natural variation among populations. It is also demonstrated that four laboratory strains of H. armigera with high levels of resistance to Cry1Ac or Cry2Ab have no cross-resistance to Vip3Aa protein. The baseline susceptibility data established here will serve as a comparative reference for detection of field-evolved resistance to Vip3Aa in H. armigera after future deployment of Bt cotton pyramids in China.
Distributed stimulation increases force elicited with functional electrical stimulation

Objective. The maximum muscle forces that can be evoked using functional electrical stimulation (FES) are relatively modest. The reason for this weakness is not fully understood but could be partly related to the widespread distribution of motor nerve branches within muscle. As such, a single stimulating electrode (as is conventionally used) may be incapable of activating the entire array of motor axons supplying a muscle. Therefore, the objective of this study was to determine whether stimulating a muscle with more than one source of current could boost force above that achievable with a single source. Approach. We compared the maximum isometric forces that could be evoked in the anterior deltoid of anesthetized monkeys using one or two intramuscular electrodes. We also evaluated whether temporally interleaved stimulation between two electrodes might reduce fatigue during prolonged activity compared to synchronized stimulation through two electrodes. Main results. We found that dual electrode stimulation consistently produced greater force (~50% greater on average) than maximal stimulation with single electrodes. No differences, however, were found in the fatigue responses using interleaved versus synchronized stimulation. Significance. It seems reasonable to consider using multi-electrode stimulation to augment the force-generating capacity of muscles and thereby increase the utility of FES systems.
Determining credibility from social network structure

The increasing proliferation of social media results in users that are forced to ascertain the truthfulness of information that they encounter from unknown sources using a variety of indicators (e.g. explicit ratings, profile information, etc.). Through human-subject experimentation with an online social network-style platform, our study focuses on the determination of credibility in ego-centric networks based on subjects observing social network properties such as degree centrality and geodesic distance. Using manipulated social network graphs, we find that corroboration and degree centrality are most utilized by subjects as indicators of credibility. We discuss the implications of the use of social network graph structural properties and use principal components analysis to visualize the reduced dimensional space.
People olympics for social innovation: Co-creating the silver sharing economy for the aging society

The emergence of unprecedented societal challenges for the humanity, as it is the case for health and wellbeing in an aging society, calls for a new extraordinary participation of the people in the innovation process. New multidisciplinary approaches, at the confluence of design, technology and life sciences, are being established to enable social innovations, which are not only good for society but also enhance society capacity to act. Social Innovation Platforms are People Driven Innovation ecosystems for societal change at large, with the objective of focusing collective intelligence to the joint intent of addressing today global societal challenges. In this paper, the principles of People Olympics for Social Innovation are discussed in relation to the Responsible Research and Innovation required for co-creating a new concept: the Silver Sharing Economy (SSE) for the Aging Society. SSE proposes a methodology based on Collaborative Innovation principles aimed to support citizens who are making the life transforming transition to retirement and to the decline of physical and mental abilities, to engage in silver product-services innovation, through a solution based on the co-creation and co-delivery of those product-services.
Soybean NIMA-Related Kinase1 Promotes Plant Growth and Improves Salt and Cold Tolerance

NEK (NIMA-related kinase) is known as a family of serine/threonine kinases which mainly participate in microtubule-related mitotic events in fungi, mammals and other eukaryotes. Our previous studies found that Arabidopsis NEK6 plays an important role in plant response to abiotic stress. We further investigated roles of the NEK family in soybean and found that at least eight members can respond to abiotic stresses. Among them, only GmNEK1, a novel NEK member which is distantly related to Arabidopsis NEK6, enhanced plant growth and promoted salt and cold tolerance in transgenic Arabidopsis plants. The growth of soybean plants harboring GmNEK1-overexpressing hairy roots under saline condition was also improved. A series of stress-related genes including RH3, CORI3 and ALDH10A8 were found to be up-regulated in GmNEK1-overexpressing Arabidopsis plants and soybean hairy roots. Moreover, soybean plants with GmRH3-overexpressing hairy roots exhibited increased salt tolerance, while soybean plants with GmRH3-RNAi (RNA interference) roots were more sensitive to salt stress than the wild-type plants. Our study uncovers a novel role for GmNEK1 in promoting plant adaptive growth under adverse conditions at least partially through up-regulation of GmRH3. Manipulation of these genes in soybean or other crops may improve growth and production under stress conditions.
Blastococcus xanthinilyticus sp. nov., isolated from monument.

A novel, non-motile, coccoid, Gram-stain-positive actinobacterium, designated BMG 862T, was isolated from a marble sample collected from the Bulla Regia monument, Northern Tunisia. Its taxonomic position was determined using a polyphasic approach. Results from chemotaxonomic analyses showed MK-9(H4), MK-8(H4) and MK-9(H2) as the predominant menaquinones. The major polar lipids comprised diphosphatidylglycerol, phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, glycophosphatidylinositol, hydroxy-phosphatidylethanolamine and three unidentified phospholipids. The fatty acids consisted of significant amounts (≥10 %) of iso-C16 : 0, C17 : 1ω8c, iso-C15 : 0 and C16 : 1ω7c. Phylogenetic analysis on the basis of 16S rRNA gene sequence comparisons showed that strain BMG 862T belongs to the genus Blastococcus, being most closely related to Blastococcus saxobsidens (=DSM 44509T) (99.5 %) and Blastococcus capsensis (=DSM 46835T=CECT 8876T) (99.3 %). The genomic DNA G+C content of the organism was 74.7 mol%. Results of DNA-DNA hybridization and physiological tests allowed differentiation of strain BMG 862T from related species. The strain was also characterized by its ability to hydrolyse xanthine. On the basis of phenotypic and molecular characteristics, strain BMG 862T (=DSM 46842T=CECT 8884T) represents the type strain of a novel species of the genus Blastococcus, for which the name Blastococcus xanthinilyticus sp. nov. is proposed.
Determination of the inflammatory component of airway diseases by induced sputum cell counts: use in clinical practice.

OBJECTIVE To evaluate the usefulness of determining the inflammatory component of airway diseases (inflammometry) by induced sputum cell counts, as well as its influence on treatment decisions in a tertiary facility for the treatment of respiratory diseases. METHODS We analyzed 151 sputum samples from 132 consecutive patients referred for clinical sputum induction by five pulmonologists between July of 2006 and February of 2007. A structured questionnaire related to the reasons for requesting the test and to the therapeutic decision making based on test results was completed by each attending physician upon receiving the test results. Induced sputum was obtained and processed according to a technique previously described. RESULTS The principal motives for ordering the test were inhaled corticosteroid dose titration in patients with moderate-to-severe asthma (in 54.3%), investigation of chronic cough (in 30.5%), and monitoring airway inflammation in patients with bronchiectasis (in 7.3%) or chronic obstructive pulmonary disease (in 6%). Of the 82 patients with asthma, 47 (57%) presented eosinophilic bronchitis (>3% eosinophils). Nonasthmatic eosinophilic bronchitis was diagnosed in 9 (19%) of the 46 patients with chronic cough. Neutrophilic bronchitis (>65% neutrophils) was found in 13 patients, of which 5 had asthma, 2 had chronic cough, and 6 had chronic obstructive pulmonary disease/bronchiectasis. Based on the induced sputum results, the corticosteroid dose was modified in 48 asthma patients (64.7%). CONCLUSIONS The systematic application of inflammometry using induced sputum cell counts can be beneficial for patients with airway diseases, particularly those with asthma or chronic cough.
PEAS-I: A hardware/software co-design system for ASIPs

The current implementation and experimental results of the PEAS-1 (practical environment for application specific integrated processor (ASIP) development - Version I) system are described. The PEAS-I system is a hardware/software co-design system for ASIP development. The input to the system is a set of application programs written in C language, an associated data set, and design constraints such as chip area and power consumption. The system generates an optimized CPU core design in the form of an HDL, as well as a set of application program development tools, such as a C compiler, assembler, and simulator. A novel method that formulates the design of an optimal instruction set using an integer programming approach is described. A tool that enables the designer to predict the chip area and performance of the design before the detailed design is completed is discussed. Application program development tools are generated in addition to the ASIP hardware design. <<ETX>>
Light micro-lensing effect in biosilica shells of diatoms microalgae

Diatoms are monocellular micro-algae provided with external valves, the frustules, made of amorphous hydrated silica. Frustules present patterns of regular arrays of holes, the areolae, characterized by sub-micrometric dimensions. In particular, frustules from centric diatoms are characterized by a radial disposition of areolae and exhibit several optical properties, such as photoluminescence variations in presence of organic vapors and photonic-crystal-like behaviour as long as propagation of electromagnetic field is concerned. We have studied the transmission of coherent light, at different wavelengths, through single frustules of Coscinodiscus Walesii diatoms, a centric species characterized by a diameter of about 150 μm. The frustules showed the ability to focalize the light in a spot of a few μm2, the focal length depending on the wavelength of the incident radiation. This focusing effect takes place at the centre of the frustule, where no areolae are present and, as it is confirmed by numerical simulations, it is probably due to coherent superposition of unfocused wave fronts coming from the surrounding areolae. Diatoms-based micro-lenses could be used in the production of lensed optical fibers without modifying the glass core and, in general, they could be exploited with success in most of the optical micro-arrays.
Our experience with Syrian refugee patients at the child and adolescent psychiatry clinic in Gaziantep, Turkey

Abstract Reporting from Turkey’s frontier with the civil war in Syria, we examined the demographic characteristics, psychiatric diagnoses and treatments for the Syrian refugee patients who have presented to Gaziantep University, Child and Adolescent Psychiatry Clinic through 2016 and the first half of 2017 retrospectively, having aimed to understand the special characteristics and needs of this novel patient group. Within a year and a half, we evaluated 51 children and adolescents and 25 (51%) had come from refugee camps, where primary healthcare services are available. Twenty-eight patients (54.9%) had special educational needs. Among our patients, there were only 15 (29.4%) girls. After our experience with refugee patients, we conclude that the role of primary healthcare services in reaching psychiatric treatment should be investigated for child refugees that special educational needs of Syrian refugees in Turkey needs urgent attention and that more research is needed to establish whether gender may be a factor in negligence of internalising symptoms by refugee families.
An Efficient Multiple Variants Coordination Framework for Differential Evolution

Differential evolution (DE) is recognized as a simple but powerful algorithm in the family of evolutionary algorithms. Over the past two decades, many advanced DE variants with significantly improved performance have been proposed. However, the variants may only achieve the best performance on a certain type of functions. Moreover, a specific optimizer may not always be suitable for the whole optimization process. To overcome these weaknesses, this paper proposes a multiple variants coordination (MVC) framework with two mechanisms, namely, the multiple variants adaptive selecting mechanism and the multiple variants adaptive solutions preserving mechanisms (MV-APM). In MVC, the evolution process is divided into nonoverlap segments with equal numbers of generations. Each segment includes the learning generations (LGs) and executing generations (EGs). In LG, all the candidate DE optimizers are utilized independently. The best performing optimizer is determined and then utilized in EG in the same segment. Furthermore, MV-APM maintains the population by adaptively preserving promising solutions generated by multiple optimizers. Numerical experiments on the CEC2014 benchmark suit show that the proposed MVC framework can significantly improve the performance of the baseline algorithms and the resulted algorithm significantly outperform the start-of-the-art and up-to-date DEs. Moreover, as a general framework, MVC can also be applied to coordinate multiple improved DE variants to further enhance their performance.
An MRI‐Based Atlas for Correlation of Imaging and Pathologic Findings in Alzheimer's Disease

Pathologic diagnosis is the gold standard in evaluating imaging measures developed as biomarkers for pathologically defined disorders. A brain MRI atlas representing autopsy‐sampled tissue can be used to directly compare imaging and pathology findings. Our objective was to develop a brain MRI atlas representing the cortical regions that are routinely sampled at autopsy for the diagnosis of Alzheimer's disease (AD).
Environmental Durability of Fibre-Reinforced Composites

The durability of the composites has been assessed in terms of the shear-lag parameter, n through the use of Raman spectroscopy. The decrease of the shear-lag parameter indicates damage due to hygrothermal ageing. The stability of the specimens subjected to the wet and dry conditions has been compared by the determined n. The n values for the wet composites have been found to decrease faster than those of the dry ones. The composites exposed to water vapour and liquid water environments were also investigated in terms of the moisture content, the mid-fibre strain and the debond length. There was no interfacial debonding for the specimen exposed to water vapour whilst the ones aged in the liquid water experienced such failure.
The best answers? Think twice: Online detection of commercial campaigns in the CQA forums

In an emerging trend, more and more Internet users search for information from Community Question and Answer (CQA) websites, as interactive communication in such websites provides users with a rare feeling of trust. More often than not, end users look for instant help when they browse the CQA websites for the best answers. Hence, it is imperative that they should be warned of any potential commercial campaigns hidden behind the answers. Existing research focuses more on the quality of answers and does not meet the above need. Textual similarities between questions and answers are widely used in previous research. However, this feature will no longer be effective when facing commercial paid posters. More context information, such as writing templates and a user's reputation track need to be combined together to form a new model to detect the potential campaign answers. In this paper, we develop a system that automatically analyzes the hidden patterns of commercial spam and raises alarms instantaneously to end users whenever a potential commercial campaign is detected. Our detection method integrates semantic analysis and posters' track records and utilizes the special features of CQA websites largely different from those in other types of forums such as microblogs or news reports. Our system is adaptive and accommodates new evidence uncovered by the detection algorithms over time. Validated with real-world trace data from a popular Chinese CQA website over a period of three months, our system shows great potential towards adaptive online detection of CQA spams.
Variability in thyroid-stimulating hormone suppression by human chorionic [corrected] gonadotropin during early pregnancy.

OBJECTIVE The objective of the study was to further explore relationships between human chorionic gonadotropin (hCG), TSH, and free T4 in pregnant women at 11 through 18 wk gestation. STUDY DESIGN The design of the study was to analyze hCG in comparison with TSH and free T4, in paired first- and second-trimester sera from 9562 women in the First and Second Trimester Evaluation of Risk for Fetal Aneuploidy trial study. RESULTS hCG is strongly correlated with body mass index, smoking, and gravidity. Correlations with selected maternal covariates also exist for TSH and free T4. As hCG deciles increase, body mass index and percent of women who smoke both decrease, whereas the percent of primigravid women increases (P < 0.0001). hCG/TSH correlations are weak in both trimesters (r2 = 0.03 and r2 = 0.02). TSH concentrations at the 25th and fifth centiles become sharply lower at higher hCG levels, whereas 50th centile and above TSH concentrations are only slightly lower. hCG/free T4 correlations are weak in both trimesters (r2 = 0.06 and r2 = 0.003). At 11-13 wk gestation, free T4 concentrations rise uniformly at all centiles, as hCG increases (test for trend, P < 0.0001), but not at 15-18 wk gestation. Multivariate analyses with TSH and free T4 as dependent variables and selected maternal covariates and hCG as independent variables do not alter these observations. CONCLUSIONS In early pregnancy, a woman's centile TSH level appears to determine susceptibility to the TSH being suppressed at any given hCG level, suggesting that hCG itself may be the primary analyte responsible for stimulating the thyroid gland. hCG affects lower centile TSH values disproportionately.
New Robust Stability Conditions and Design of Robust Stabilizing Controllers for Takagi–Sugeno Fuzzy Time-Delay Systems

In this paper, we consider robust stability and stabilization of uncertain Takagi-Sugeno fuzzy time-delay systems where uncertainties come into the state and input matrices. Some stability conditions and robust stability conditions for fuzzy time-delay systems have already been obtained in the literature. However, those conditions are rather conservative and do not guarantee the stability of a wide class of fuzzy systems. This is true in case of designing stabilizing controllers for fuzzy time-delay systems and it thus leads to a conservative fuzzy controller design as well. We first consider rather relaxed robust stability conditions of uncertain fuzzy systems. To this end, we introduce an auxiliary system to the original fuzzy time-delay system to obtain generalized delay-dependent stability conditions. Such an auxiliary system has some arbitrary matrices that generalize not only the system representation but also delay-dependent stability conditions. Conditions we obtain here are delay-dependent conditions that depend on the upper bound of time-delay, and are given in terms of linear matrix inequalities (LMIs). Then, we compare our delay-dependent stability conditions with other conditions in the literature, and show that our conditions guarantee the stability of a wider class of systems than others. Next, we consider the robust stabilization problem with memoryless and delayed state feedback controllers. Based on our generalized robust stability conditions, we obtain delay-dependent sufficient conditions for the closed-loop system to be robustly stable, and give a design method of robustly stabilizing controllers. Finally, we give three examples that illustrate our results.
A robust and fast 3D face reconstruction method using realsense camera

In this paper, we propose a fast method to reconstruct a plausible 3D face by deforming a standard face model, constraint to 78 landmarks acquired by Intel realsense camera. First, we calculate the front view coordinates of the 78 landmarks by the Eulerian angle information acquired and scale the front view coordinates to fit the standard model. Second, we calculate a transformation matrix which calculate the displacement of all the points in the face through the displacement of the landmarks. Finally, based on the results of the second, we adjust all the points of the model to best fit the real face. Experimental results demonstrate the effectiveness and efficiency of our method, as well as the robust adaptation to face pose and efficiency of the algorithm.
Arabidopsis thaliana as a model organism in systems biology

Significant progress has been made in the identification of genes and gene networks involved in key biological processes. Yet, how these genes and networks are coordinated over increasing levels of biological complexity, from cells to tissues to organs, remains unclear. To address complex biological questions, biologists are increasingly using high‐throughput tools and systems biology approaches to examine complex biological systems at a global scale. A system is a network of interacting and interdependent components that shape the system's unique properties. Systems biology studies the organization of system components and their interactions, with the idea that unique properties of that system can be observed only through study of the system as a whole. The application of systems biology approaches to questions in plant biology has been informative. In this review, we give examples of how systems biology is currently being used in Arabidopsis to investigate the transcriptional networks regulating root development, the metabolic response to stress, and the genetic regulation of metabolic variability. From these studies, we are beginning to obtain sufficient data to generate more accurate models for system function. Further investigation of plant systems will require data gathering from specific cells and tissues, continued improvement in metabolic technologies, and novel computational methods for data visualization and modeling. Copyright © 2009 John Wiley & Sons, Inc.