Miracle-dz/UniFAR-FTUs huggingface dataset:
Reduction Mercury-Polluted Water in Gold Minewith Anaerobic Bacteria Prima

To develop biotechnology for biological treatment of mercury-contaminated wastes or for bioremediation of mercury-polluted sites, mercury-resistant microorganisms have been isolated and characterized. However, understanding of bioremidiation mechanism by anaerobic bacteria. In this study, we tried to isolate anaerobic mercury-resistant bacteria from mercury-polluted water in Bombana Gold Mine, indonesia. One strain of the bacterial isolates, was used for the identification and for the growth capability of mercurials. We also analyzed genetic characteristics of mercury resistance genes (merA gene) from this strain. The strain Bombana, which was isolated from Bombana Gold Mine water, was identified as Flavobacterium sp. and showed resistance to both inorganic mercury. Furthermore, nucleotide sequence analysis showed that merA genes of the strain Bombana were identical of Staphylococcus aureus dan Streptomyces coelicoloran aerobic mercury-resistant bacterium in the nucleotide sequence level. The study describes a mercury bioaccumulating bacteria from Bombana. , which remediated mercury from the medium simultaneous to its growth. The applicability of the bacterial cells in removing mercury from synthetic effluent in a batch mode was amply demonstrated. The initial load of 50 ppm mercury in effluent was completely removed in 6 days.
Neurophysiological Evidence for Altered Higher Brain Functions in NIDDM

OBJECTIVE To investigate neurophysiological alterations of higher brain function in patients with NIDDM. RESEARCH DESIGN AND METHODS Auditory P300 event-related potentials were recorded in 60 NIDDM patients who had no evidence of stroke, dementia, or any other neurological illnesses. The P300 wave latencies in diabetic patients were compared with those in neurologically healthy control subjects, with consideration of clinical parameters and diabetic complications. RESULTS Diabetic patients had significantly longer P300 latencies than control subjects. Seven diabetic patients had pathologically prolonged P300 values. There was a trend toward longer P300 latencies in diabetic patients with retinopathy and in those with HbA1 of ≥10%; the differences between these diabetic subgroups and control subjects were both statistically significant. However, three of seven diabetic patients with abnormal P300 latencies had no retinal lesions, and no significant correlation was observed among diabetic patients between P300 latencies and HbA1 levels. Peripheral neuropathy, nephropathy, blood glucose levels, and disease duration appeared not to correlate with P300 alterations. CONCLUSIONS These findings suggest the presence of central nervous pathological processes in NIDDM that affect higher brain functions, as assessed by P300 latencies. Our findings also suggest that microangiopathy and metabolic derangement during the preceding 4- to 8-week period may contribute in small part to the pathophysiology of this central nervous involvement.
Online Health Communication about Human Genetics: Perceptions and Preferences of Internet Users

Unprecedented advancements in human genetics research necessitate keeping the public abreast of new information, applications, and implications and the Internet represents an important method of communicating with the public. Our research used cross-sectional self-report survey data collected from a diverse convenience sample of 780 Internet users in two states. Multivariate regression analysis explored the relationships between experiences, perceptions, and preferences for online health and genetics communication. Online health information seeking was associated with previous genetic information seeking, comfort with online genetic communication, perceived risk for genetic abnormality, being female, and having more education. Comfort with online genetics communication was associated with a preference for online genetic information, previous online health and off-line genetics information seeking, having a healthy lifestyle, believing in the positive impact of human genetics research, and being female. Perceiving online health information to be accurate was associated with preferring the Internet for genetics communication, being older, less educated, and perceiving Internet use as anonymous. Preferring online genetics communication to other communication channels was associated with perceiving online health information as accurate, being comfortable receiving online genetics information, having lower intrinsic religiosity, and being male. The implications of findings for Web-based health message design are discussed.
Modeling to aid management of marine top predators in a changing climate

Marine top predators can include species that occupy a high trophic level (e.g., predatory sharks), have few predators (e.g., marine turtles), or can exert topdown control on food webs due to their large energetic demands (e.g., whales). While many species in the open ocean are widely distributed (e.g., Read et al. 2013; Reygondeau et al. 2012), the higher trophic levels are noteworthy as they are also wide-ranging (e.g., tuna (Itoh et al. 2003; Block et al. 2011; Hobday et al. 2015), seabirds (Shaffer et al. 2006), turtles (Shillinger et al. 2008; Briscoe et al. 2016)). These wide-ranging species can serve as ecological linkages within and across ocean basins, through both ontogenetic (larvae to adult) and seasonal migrations (Boustany et al. 2010; Hobday et al. 2015; Briscoe et al. 2016). Many wide-ranging marine animals show site fidelity at particular times during their lives or have relatively small and well-defined areas of critical habitat, which facilitates both exploitation (e.g., Hobday et al. 2015) and protection (e.g., Ban et al. 2014). This fidelity can be related to the temporal and spatial predictability of their physical habitats, as evidenced by predictable seasonal aggregations of high-trophic fishes, birds, turtles, and mammals (Scales et al. 2014), which is aided by sensory capabilities that permit them to locate specific physical and biological features.
Lung Microvessicles May Hold Clues to Lung Transplant Failure.

F years, investigators looking at histology through electron microscopy dismissed the frequently observed small round vesicles found in the intracellular spaces as artifacts. It was not until investigators made the observation in the early 1980s that the vesicles recovered from cultures of a tumor cell line could profoundly affect thrombin activation that the biological function of these entities was appreciated. These extracellular bodies, termed microvessicles (MV), range in size from 30 to 300 nm. Rather than existing as inert products of cell division and turnover, we now understand them to function in biology as efficient cell signaling vehicles. They have been implicated in such disparate processes as coagulation, neural regeneration, cancer metastasis, and proinflammatory and anti-inflammatory processes. Furthermore, MVs may emerge from a range of cell types, including platelets, macrophages, bone marrow–derived mesenchymal stromal cells, and epithelial cells. The MVs, which bud off from the cell surface of healthy and apoptotic cells, act as intermediaries between cells to deliver their cargo which may include procoagulants, chemokines, messenger RNAs, and microRNAs. The past decade haswitnessed a surge in enthusiasm forMVs in disease pathogenesis with 36 Pubmed citations in 2004 and 379 in 2014. There are now societies for MVs and exosomes, international meetings, and a recently introduced Journal of Extracellular Vessicles. In keeping with this growing enthusiasm for MVs across disciplines, there have been hints to their relevance in solid organ transplantation. The strongest body of work to date has focused on the role of MVs in renal ischemia reperfusion. Preclinical studies have shown that the addition of MV derived from mesenchymal stromal cells prevents renal damage in a rodent ischemia reperfusion injury model. Exosomes, often grouped with MVs, are small 30 to 90 nm extracellular bodies. Recent experiments of urinary sediment from renal transplant recipients have shown that acute rejection is associated with a unique exosome profile. Until now, there were no reports of MVs in clinical lung transplantation. In this issue, Harms and colleagues report on their findings in clinical lung transplantation. An unmet need in clinical lung transplantation is detecting injury and immune activation signals before they result in irreversible
Circadian rhythm sleep disorders following mild traumatic brain injury

Objective: To describe the physiologic and behavioral characteristics of circadian rhythm sleep disorders (CRSDs) following minor traumatic brain injury (mTBI) in patients complaining of insomnia. Methods: Forty two patients with insomnia complaints following mTBI were screened. Those suspected of having CRSD underwent actigraphy, saliva melatonin and oral temperature measurement, and polysomnography. All patients also filled out a self-reported questionnaire to determine their circadian preference. Results: Fifteen of the 42 patients (36%) with complaints of insomnia following mTBI were diagnosed with CRSD. Eight patients displayed a delayed sleep phase syndrome (DSPS), whereas seven displayed an irregular sleep–wake pattern (ISWP). Whereas all patients with DSPS exhibited a 24-hour periodicity of oral temperature rhythm, three of seven patients with ISWP lacked such a daily rhythm. In addition, ISWP patients exhibited smaller amplitude of oral temperature rhythm vs the DSPS group. Subjective Morningness–Eveningness Questionnaire scores were in accordance with the clinical diagnosis of DSPS or ISWP based on actigraphy. Conclusions: Minor traumatic brain injury might contribute to the emergence of circadian rhythm sleep disorders. Two types of these disorders were observed: delayed sleep phase syndrome and irregular sleep–wake pattern. The types differed in the subjective questionnaire scores and had distinct profiles of melatonin and temperature circadian rhythms.
Overexpression of monosialoganglioside GM3 on lymphocyte plasma membrane in patients with HIV infection.

SUMMARY This study was undertaken to analyze both the GM3 expression on peripheral blood lymphocytes of HIV-infected patients and the relationship between ganglioside content and anti-GM3 reactivity. GM3 expression was determined as a percentage of lipid-bound sialic acid and by cytofluorimetric analysis in 25 AIDS patients, 20 anti-HIV+ asymptomatic subjects, 25 patients with different viral disease, and 25 healthy donors. GM3 distribution was analyzed by immunofluorescence and immunoelectron microscopy. A follow-up study to detect anti-lymphocytic GM3 antibodies was performed in progressive and nonprogressive anti-HIV+ subjects. Lymphocytes from HIV-infected patients showed a significant increase of plasma membrane GM3 content; no difference was found between CD4+ and CD8+ cells. Immunofluorescence and immunoelectron microscopic analysis showed that GM3 was distributed in large clusters over the cell plasma membrane. The follow-up study revealed that the occurrence of anti-lymphocytic GM3 antibodies was significantly higher in patients with progressive disease, compared with asymptomatic non-progressive subjects. These findings revealed that (1) the increased GM3 content in HIV-infected patients is detected at the plasma membrane level, (2) GM3 overexpression is able to induce an increased reactivity with anti-GM3 antibodies, and (3) the appearance of anti-lymphocytic GM3 antibodies in asymptomatic anti-HIV+ subjects could have prognostic relevance for the risk of developing AIDS.
JOB STRESS AND BURNOUT AMONG HOSPITAL NURSES IN A CITY OFMYANMAR

This cross-sectional study aimed to determine factors related to job stress in nurses. A total of 300 professional nurses at public and private hospitals in Yangon Region, Myanmar were recruited. Self-administrative questionnaires were distributed to the nurses who were 20-60 years of age in May 2015. Chi-square tests and multiple logistic regressions were employed for data analysis. The study revealed that 50.2% of nurses hadhighjob stress and tendencytoburnout. Ithad a significantassociationwithtype of hospitals, working position, years of services, workmotivation, autonomy, and recognition. Multiplelogisticregressionshowedsignificantpredictors of nurses’job stress and burnout were; those in private hospitals (AOR: 1.78; 95%CI: 1.03-3.06), being in senior position (AOR: 1.83; 95%CI: 1.13-2.95) and high work motivation (AOR: 3.14; 95%CI: 1.45-6.77). Based on the study results, effort should be made to reduce nurses’stress included; setting the strategies to increase in senior nurses, especially those in private sector.
Nine‐year follow‐up in a child with chromosomal integration of human herpesvirus 6 transmitted from an unrelated donor through the Japan Marrow Donor Program

H. Yagasaki, H. Shichino, N. Shimizu, T. Ohye, H. Kurahashi, T. Yoshikawa, S. Takahashi. Nine-year follow-up in a child with chromosomal integration of human herpesvirus 6 transmitted from an unrelated donor through the Japan Marrow Donor Program. Transpl Infect Dis 2015: 17: 160–161. All rights reserved H. Yagasaki, H. Shichino, N. Shimizu, T. Ohye, H. Kurahashi, T. Yoshikawa, S. Takahashi Pediatrics, School of Medicine, Nihon University, Tokyo, Japan, Department of Virology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan, Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan, Pediatrics, School of Medicine, Fujita Health University, Aichi, Japan
B7x: A widely expressed B7 family member that inhibits T cell activation

B7 family proteins provide costimulatory signals that regulate T cell responses. Here we report the third set of B7 family-related T cell inhibitory molecules with the identification of a homolog of the B7 family, B7x. It is expressed in immune cells, nonlymphoid tissues, and some tumor cell lines. B7x inhibits cell-cycle progression, proliferation, and cytokine production of both CD4+ and CD8+ T cells. B7x binds a receptor that is expressed on activated, but not resting T cells that is distinct from known CD28 family members. Its receptor may be a recently identified inhibitory molecule, B and T lymphocyte attenuator. These studies identify a costimulatory pathway that may have a unique function in downregulation of tissue-specific autoimmunity and antitumor responses.
Improved recursive procedures for envelope-constrained filtering

This paper presents new recursive procedures for designing optimum envelope-constrained (EC) filters. Using a constraint transcription technique, the inequality constrained quadratic programming problem associated with EC filtering can be approximated as an unconstrained minimization problem. Two types of optimization methods are developed to solve this unconstrained problem in a recursive adjusting manner. Simulations of the proposed recursive procedures are presented which support the theoretical predictions.
A Distributed Learning Automata Scheme for Spectrum Management in Self-Organized Cognitive Radio Network

We propose a distributed Learning Automata (LA) for spectrum management problem in Cognitive Radio (CR) networks. The objective is to design intelligent Secondary Users (SUs) which can interact with the RF environment and learn from its different responses through the sensing. It is assumed there is no prior information about the Primary Users (PUs) and other SUs activities while there is no information exchange among SUs. Each SU is empowered with an LA which operates in the RF environment with different responses. That is, the SUs are considered as agents in a self-organized system which select one channel as an action and receive different responses from the environment based on how much their selected actions are favorable or unfavorable. Using these responses, SUs control their accesses to the channels for appropriate spectrum management with the objective to incur less communication delay, less interference with PUs, and less interference with other SUs. The proposed LA-based distributed algorithm is investigated in terms of asymptotic convergence and stability. Simulation results are provided to show the performance of the proposed scheme in terms of SUs’ waiting times, interference with other SUs, the number of interruptions by PUs during their transmissions, and fairness.
Quantum Walks, Open Quantum Walks, Quantum Computation and Related Topics Marches quantiques, marches quantiques ouvertes, calcul quantique et sujets connexes

We use representation theory of groups to classify coin operators of different quantum walks and provide an unified framework. We formulate quantum walks on Plancherel decompositions that are guaranteed by Peter-Weyl theorem for compact groups satisfying axiom of second countability. We build a quantum probability space and derive standard quantum walks such as Hadamard walk, Pauli operators based quantum Bernoulli processes, and walks on angular momentum space within this framework. We also outline their asymptotic behavior for different initial states using functional central limit theorems on Fock spaces, toy for time-discrete and true for time-continuous walks respectively, in terms of conjugate Brownian motions and Poisson processes. A step of the walker described in terms of annihilation and creation operators on Fock spaces provides insights into the relation between discrete and continuous time quantum walks.
Dynamic systems, maturational constraints and L1 phonetic attrition

The present study comprises a phonetic analysis of the lateral phoneme /l/ in the first (L1) and second language (L2) of 10 late German–English bilinguals. The primary objective of the study was to compare the predictive power of dynamic systems theory with that of maturational constraints through a phonetic investigation of L1 attrition in the lateral phoneme /l/ of the late bilinguals. The results revealed L1 attrition in the lateral phoneme /l/, as well as a high degree of interpersonal and intrapersonal variation. These patterns are discussed in relation to dynamic systems theory and maturational constraints. Moreover, the degree of permanency of L1 attrition is discussed in relation to methodological considerations in studies on L1 attrition. It is proposed that maturational constraints are insufficient in explaining the results and that bilingual language development can be more adequately explained through dynamic systems theory, which explicitly incorporates a multitude of predictor variables across the lifespan, in addition to age constraints.
FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor.

UNLABELLED Patient stratification biomarkers that enable the translation of cancer genetic knowledge into clinical use are essential for the successful and rapid development of emerging targeted anticancer therapeutics. Here, we describe the identification of patient stratification biomarkers for NVP-BGJ398, a novel and selective fibroblast growth factor receptor (FGFR) inhibitor. By intersecting genome-wide gene expression and genomic alteration data with cell line-sensitivity data across an annotated collection of cancer cell lines called the Cancer Cell Line Encyclopedia, we show that genetic alterations for FGFR family members predict for sensitivity to NVP-BGJ398. For the first time, we report oncogenic FGFR1 amplification in osteosarcoma as a potential patient selection biomarker. Furthermore, we show that cancer cell lines harboring FGF19 copy number gain at the 11q13 amplicon are sensitive to NVP-BGJ398 only when concomitant expression of β-klotho occurs. Thus, our findings provide the rationale for the clinical development of FGFR inhibitors in selected patients with cancer harboring tumors with the identified predictors of sensitivity. SIGNIFICANCE The success of a personalized medicine approach using targeted therapies ultimately depends on being able to identify the patients who will benefit the most from any given drug. To this end, we have integrated the molecular profiles for more than 500 cancer cell lines with sensitivity data for the novel anticancer drug NVP-BGJ398 and showed that FGFR genetic alterations are the most significant predictors for sensitivity. This work has ultimately endorsed the incorporation of specific patient selection biomakers in the clinical trials for NVP-BGJ398.
Paradoxes in LET standardisation – towards an improved process

This paper is motivated by paradoxes and frustrations in the practice of learning technology standardisation. Case studies and participatory observations suggest that stakeholder engagement is key to an improved process. As industry involvement is hard to achieve in a fragmented market, the author suggests that government interests should step up their engagement to speed up the development cycle of idea formation, specification and implementation.
Antileishmanial activity of the essential oil from Tetradenia riparia obtained in different seasons

The herbaceous shrub Tetradenia riparia has been traditionally used to treat inflammatory and infectious diseases. Recently, a study showed that T. riparia essential oil (TrEO) obtained in summer has antileishmanial effects, although these results could be influenced by seasonal variation. This study evaluated the activity of the TrEO obtained in different seasons against Leishmania (Leishmania) amazonensis, in vitro and in vivo. The compounds in the TrEO were analysed by gas chromatography-mass spectrometry; terpenoids were present and oxygenated sesquiterpenes were the majority compounds (55.28%). The cytotoxicity and nitric oxide (NO) production were also tested after TrEO treatment. The TrEO from all seasons showed a 50% growth inhibitory concentration for promastigotes of about 15 ng/mL; at 30 ng/mL and 3 ng/mL, the TrEO reduced intracellular amastigote infection, independently of season. The TrEO from plants harvested in summer had the highest 50% cytotoxic concentration, 1,476 ng/mL for J774.A1 macrophages, and in spring (90.94 ng/mL) for murine macrophages. NO production did not change in samples of the TrEO from different seasons. The antileishmanial effect in vivo consisted of a reduction of the parasite load in the spleen. These results suggest that the TrEO has potential effects on L. (L.) amazonensis, consonant with its traditional use to treat parasitic diseases.
Developing a Model of Continuous Online Social Network Usage

This research examines the sources and consequences of stress when using online social networks (OSN). In a first step, the five OSN-induced stressors invasion, pattern, complexity, uncertainty, and disclosure are identified. In a second step, the Model of Continuous OSN Usage is developed in order to examine the influence of these five stressors. Therefore, the model is based on the Model of Adoption of Technology in Households and the Post-Acceptance Model. Results of an empirical analysis with 154 OSNs users reveal that 57 per cent of satisfaction and 64 per cent of continuous usage intention can be explained within the Model of Continuous OSN Usage. Notably, the five stressors have a higher strength of effect on satisfactions than the three attitudinal beliefs hedonic, utilitarian, and social outcomes altogether. In summary, the results offer a theoretical foundation for recent practical observations that OSNs are a source and symbol of stress.