Miracle-dz/UniFAR-FTUs huggingface dataset:
Electrophysiological and neurochemical study of the rat geniculo‐cortical pathway. Evidence for glutamatergic neurotransmission

The projection from the dorsal lateral geniculate nucleus to the primary visual cortex of the rat was studied electrophysiologically. Electrical stimulation of the dorsal lateral geniculate nucleus and the optic tract produced three types of responses on neurons of area 17: excitation followed by inhibition, excitation and inhibition. These results extend and confirm, in adult rats, previous studies done in rat geniculate‐visual cortex cocultures preparations in vitro. The role of glutamate in the neurotransmission of the rat geniculo‐cortical pathway was also investigated. In a first set of experiments, the effects of kynurenate, an antagonist of glutamate receptors, on visual cortex neurons with a monosynaptic excitatory response to dorsal lateral geniculate nucleus stimulation were studied. Microiontophoresis of kynurenate in area 17 neurons selectively suppressed the excitatory response to dorsal lateral geniculate nucleus and optic tract stimulation. In a second set of experiments, the effects of electrical stimulation of the dorsal lateral geniculate nucleus and the optic tract on the release of amino acids in the rat visual cortex in vivo were studied. Using the push–pull method, we perfused a discrete region of the visual cortex with artificial cerebrospinal fluid (CSF), and the amino acid content of the perfusates was analysed by high performance liquid chromatography (HPLC). Stimulation of either the dorsal lateral geniculate nucleus or the optic tract significantly increased glutamate release in area 17. The rest of the amino acids studied did not show significant changes. The results provide evidence for the participation of glutamate in the neurotransmission of the geniculo‐cortical pathway in the rat.
Therapeutic potential of electromagnetic fields for tissue engineering and wound healing

Ability of electromagnetic fields (EMF) to stimulate cell proliferation and differentiation has attracted the attention of many laboratories specialized in regenerative medicine over the past number of decades. Recent studies have shed light on bio‐effects induced by the EMF and how they might be harnessed to help control tissue regeneration and wound healing. Number of recent reports suggests that EMF has a positive impact at different stages of healing. Processes impacted by EMF include, but are not limited to, cell migration and proliferation, expression of growth factors, nitric oxide signalling, cytokine modulation, and more. These effects have been detected even during application of low frequencies (range: 30–300 kHz) and extremely low frequencies (range: 3–30 Hz). In this regard, special emphasis of this review is the applications of extremely low‐frequency EMFs due to their bio‐safety and therapeutic efficacy. The article also discusses combinatorial effect of EMF and mesenchymal stem cells for treatment of neurodegenerative diseases and bone tissue engineering. In addition, we discuss future perspectives of application of EMF for tissue engineering and use of metal nanoparticles activated by EMF for drug delivery and wound dressing.
Eating disorders and pregnancy: Proposed treatment guidelines for obstetricians and gynecologists

Pregnant women with eating disorders are at risk for multiple complications to both the woman and the fetus. Eating disorders are particularly prevalent among adolescent girls and young women. This paper suggests a road map for the obstetrician gynecologist caring for women who either have an active eating disorder, report a history of a prior eating disorder, or when the clinician suspects that the woman may have an eating disorder which has not been previously identified. Proposed treatment guidelines are outlined.
Increased Axon Number in the Anterior Commissure of Mice Lacking a Corpus Callosum

Relatively few behavioral deficits are apparent in subjects with hereditary absence of the corpus callosum (CC). The anterior commissure (AC) has been suggested to provide an extracallosal route for the transfer of interhemispheric information in subjects with this congenital defect. Anterior commissure size, axon number, axon diameter, and neuronal distribution were compared between normal mice and those with complete CC absence. No difference in midsagittal AC area was found between normals and acallosals, nor were differences found in the numbers or diameters of myelinated axons. However, axon counts indicated an 17% increase or about 70,000 more unmyelinated axons in the AC of acallosal mice, and the mean diameter of unmyelinated axons was slightly less than in normal mice (0.24 vs 0.26 microm). This decrease in axon diameter enabled more axons to pass through the AC without increasing its midsagittal area. The topographical distribution of neurons sending axons through the AC, assessed with lipophilic dyes, was qualitatively similar for almost all the known regions of origin of the anterior commissure in normal and acallosal mice. There was a pronounced deficit of AC cells in the anterior piriform cortex of BALB/c mice, but this occurred whether or not the mouse suffered absent CC. Although the increase in AC axon number is far smaller than the number of CC axons that fail to reach the opposite hemisphere, the higher number of axons present in the AC of acallosal mice may contribute to the functional compensation for the loss of the CC.
Protein Kinase and Specific Phosphate Acceptor Proteins Associated with Vaccinia Virus Cores

Incubation of purified vaccinia virus with γ-32P-adenosine triphosphate resulted in the incorporation of 32P into hot trichloroacetic acid-insoluble material. Enzymatic activity was completely dependent on the addition of divalent cations and was stimulated by nonionic detergents and dithiothreitol. Chemical studies demonstrated that serine and threonine residues of 15,000 molecular weight viral polypeptides were phosphorylated. In contrast, the major structural proteins were not phosphorylated or were phosphorylated to a much lesser extent. Added histones and protamine, but not serum albumin, casein, or phosvitin were phosphorylated by the partially disrupted vaccinia virus preparations. The protein kinase was tightly associated with vaccinia virus particles since the specific enzymatic activity remained constant during the final steps of virus purification, the specific activities of many different preparations of virus were similar, and the enzymatic activity cosedimented with vaccinia virus during rate zonal sucrose gradient and potassium tartrate gradient equilibrium centrifugations. Controlled degradation of vaccinia virus, with nonionic detergents and dithiothreitol, indicated that both the protein kinase and the specific phosphate acceptor proteins were located in the virus core.
Mindfulness and the mindfulness assessment scales

Objective To review mindfulness and the mindfulness assessment scales according to Kabat-Zinn’ s concept. Materials and methods Documentary reviewed by using 2 words i.e. sati and mindfulness as key words to search via Google search engine from December 2013 – April 2014. Results There were 24 articles retrieved. According to Kabat-Zinn, mindfulness composed 2 domains i.e., 7 items of cognitive domain and 5 items of affective domian which magnified by Shaprio and Swartz. Bishoped et al described an operation definition composed 2 factors that is, awareness and acceptance which 7 assessment scales’ developers used to generate the items. There were eight assessment scales based on self report containing 1-5 domains and were vary between 10–39 items. The differences in culture and concept of mindfulness practice impact the application of these assessment scales in Thailand. Conclusion Mindfulness and the assessment scales according to Kabat-Zinn had both positive and limited issues in Thailand.
Current Concepts in Acetabular Positioning in Total Hip Arthroplasty

Being one of the most successful surgeries in the history of medicine, the indications for total hip arthroplasty have widened and are increasingly being offered to younger and fitter patients. This has also led to high expectations for longevity and outcomes. Acetabular cup position has a significant impact on the results of hip arthroplasty as it affects dislocation, abductor muscle strength, gait, limb lengths, impingement, noise generation, range of motion (ROM), wear, loosening, and cup failure. The variables in cup position are depth, height, and angular position (anteversion and inclination). The implications of change in depth of center of rotation (COR) are medialized versus anatomical positioning. As opposed to traditional medialization with beneficial effects on joint reaction force, the advantages of an anatomical position are increasingly recognized. The maintained acetabular offset offers advantages in terms of ROM, impingement, cortical rim press fit, and mamtaining medial bone stock. The height of COR influences muscle activity and limb lengths and available bone stock for cup support. On the other hand, ideal angular position remains a matter of much debate and reliably achieving a target angular position remains elusive. This is not helped by variations in the way we describe angular position, with operative, radiologic, or anatomic definitions being used variably to describe anteversion and inclination. Furthermore, pelvic tilt plays a major role in functional positions of the acetabulum. In addition, commonly used techniques of positioning often do not inform us of the real orientation of the pelvis on operating table, with possibility of significant adduction, flexion, and external rotation of the pelvis being possibilities. This review article brings together the evidence on cup positioning and aims to provide a systematic and pragmatic approach in achieving the best position in individual cases.
Seroprevalence of hepatitis E virus (HEV) antibody and the possible association with chronic liver disease: a case-control study in Albania

SUMMARY A case-control study involving 109 in-patients with chronic liver disease and 190 in-patients with no apparent liver disease was conducted to evaluate the seroprevalence of anti-HEV antibodies and the possible association with chronic liver disease. Among cases, the anti-HEV prevalence was 36·6% which increased significantly by age; among controls, the prevalence was 12·1% (P<0·05) and was similar among age groups <60 years. Among cases, aged >50 years (OR 4·0, 95% CI 1·4–11) and the presence of end stage liver disease (ESLD) (OR 4·3, 95% CI 1·4–12·8) were associated independently with anti-HEV positivity. The mean optical density, determined by anti-HEV immunoenzymatic test, was significantly higher among patients with ESLD, compared to the other patients. These results indicate that there is a high seroprevalence of anti-HEV in patients with chronic liver disease and a possible association between HEV infection and/or anti-HEV production and advanced stage chronic liver disease.
CDR3 length in antigen-specific immune receptors

In both immunoglobulins (Ig) and T cell receptors (TCR), the rearrangement of V, D, and J region sequence elements during lymphocyte maturation creates an enormous degree of diversity in an area referred to as the complementarity determining region 3 (CDR3) loop. Variations in the particular V, D, and J elements used, precise points of recombination, and random nucleotide addition all lead to extensive length and sequence heterogeneity. CDR3 loops are often critical for antigen binding in Igs and appear to provide the principal peptide binding residues in TCRs. To better understand the physical and selective constraints on these sequences, we have compiled information on CDR3 size variation for Ig H, L (kappa and lambda) and TCR alpha, beta, gamma, and delta. Ig H and TCR delta CDR3s are the most variable in size and are significantly longer than L and gamma chains, respectively. In contrast, TCR alpha and beta chain distributions are highly constrained, with nearly identical average CDR3 lengths, and their length distributions are not altered by thymic selection. Perhaps most significantly, these CDR3 length profiles suggest that gamma/delta TCRs are more similar to Igs than to alpha/beta TCRs in their putative ligand binding region, and thus gamma/delta and alpha/beta T cells may have fundamentally different recognition properties.
Language modeling using x-grams

In this paper, an extension of n-grams, called x-grams, is proposed. In this extension, the memory of the model (n) is not fixed a priori. Instead, large memories are accepted first, and merging criteria are then applied to reduce the complexity and to ensure reliable estimations. The results show how the perplexity obtained with x-grams is smaller than that of n-grams. Furthermore, the complexity is smaller than trigrams and can become close to bigrams.
Language design for programming reliability

The language in which programs are written can have a substantial effect on their reliability. This paper discusses the design of programming languages to enhance reliability. It presents several general design principles, and then applies them to particular languages constructs. Since the validity of such design principles cannot be logically proved, empirical evidence is needed to support or discredit them. A major experiment to measure the effect of nine specific language-design decisions in one context has been performed. Analysis of the frequency and persistence of errors shows that several decisions had a significant impact on reliability.
BIST-RM: BIST-assisted reliability management of SoCs using on-chip clock sweeping and machine learning

In this paper, we present a novel methodology, BIST-RM, to accurately predict the degradation due to aging mechanisms in a SoC at run-time by utilizing the existing LBIST hardware and software implemented Machine Learning classifier. Using an innovative method, we convert ATPG-generated transition delay patterns into LBIST patterns, and the corresponding responses are utilized in developing the predictor. A gate-overlap and path delay-aware pattern selection algorithm selects the features for the classier. Using clock sweeping, LBIST is able to capture the aging effect on targeted paths. The result of machine learning is then utilized to activate countermeasures to remedy the degradation in the field. The area and test time overhead are very low. We implemented our proposed flow on SoC benchmark circuits, and the results demonstrated worst-case prediction accuracy of 94% to 97%.
101 hepatectomies under continuous inflow occlusion following simple in-situ liver cooling in patients with chronic liver diseases.

BACKGROUND/AIMS Hepatic inflow occlusion involves the serious disadvantage of ischemic injury to the remnant liver, particularly in patients with injured parenchyma. Liver hypothermia is one of the solutions for this problem. The purpose of this study was to evaluate simple in-situ liver cooling method of performing hepatic resection under continuous inflow occlusion in patients with chronic liver disease. METHODOLOGY One hundred and one patients with chronic hepatitis (n = 26) and cirrhosis (n = 75) were included in this retrospective study. They underwent hepatectomy under conditions of continuous inflow occlusion immediately following simple in-situ liver cooling. Laboratory data and intraoperative and postoperative variables were analyzed for the three groups of patients stratified according to the lowest liver tissue temperature achieved: group 1 (> or = 30 degrees C, n = 16), group 2 (< 30 degrees C and > or = 25 degrees C, n = 62) and group 3 (< 25 degrees C, n = 20). RESULTS Our simple in-situ liver cooling method enabled us to safely resect chronically diseased liver under continuous inflow occlusion (49.8 +/- 7.7 min, mean +/- SD; range, 30 to 70 min) with acceptable operative blood loss (894 +/- 853mL), morbidity (22.7%, 23/101) and mortality (1.0%, 1/101); one patient died of complications unrelated to ischemic injury. Analysis demonstrated that simple liver hypothermia was substantially hepatoprotective against ischemic injury in terms of serum transaminase levels and duration of inflow occlusion, particularly when the liver tissue temperature fell below 30 degrees C (groups 2 and 3). CONCLUSIONS Hepatic inflow occlusion can be safely employed in a continuous manner for approximately 1 hour, even during resection of chronically diseased liver, particularly when the liver is cooled below 30 degrees C prior to hepatic clamping by our simple in-situ hypothermia technique.
Alcohol abstinence in patients surviving an episode of alcoholic hepatitis: Prediction and impact on long‐term survival

Alcoholic hepatitis (AH) is the most severe form of alcoholic liver disease. Most studies have focused on short‐term prognosis, whereas factors associated with long‐term survival are largely unknown. The aims of our study were to (1) determine the impact of complete abstinence from alcohol on long‐term survival and (2) identify prognostic factors at admission capable of predicting abstinence during long‐term follow‐up in patients with AH. One hundred forty‐two patients with biopsy‐proven AH that survived the first episode were included. Demographic, psychiatric, and biochemical variables at admission and drinking status during follow‐up were obtained. Cox regression, logistic regression, and classification and regression trees (CART) analyses were used for statistical analysis. Overall mortality was 38% with a median follow‐up of 55 months. During follow‐up, complete abstinence was reported in 39% and was associated with better long‐term survival (hazard ratio, 0.53; P = 0.03). After adjustment for baseline prognostic scoring systems (Model for End‐Stage Liver Disease and age, bilirubin, international normalized ratio, creatinine scores), complete abstinence was independently associated with survival (P < 0.05). Age and lack of past alcoholism treatments were independently associated with complete abstinence (P < 0.001 and P = 0.02, respectively) during follow‐up. CART analysis generated a simple and practical algorithm based on the combination of past alcoholism treatments and age. Using CART analysis, we stratified 2 subgroups of patients with high (65%) and low (26%‐29%) rates of complete abstinence after an episode of AH. Conclusion: Complete abstinence after an episode of AH positively impacts long‐term survival. The combination of 2 variables easily obtained at admission might be useful to predict long‐term abstinence after an episode of AH. Strategies aimed at promoting alcohol abstinence in these patients are necessary. (Hepatology 2017;66:1842–1853)
Does Education Matter?: Myths About Education and Economic Growth

In the twenty-first century, education has come to be regarded as a precondition of economic success. Developed countries, having moved beyond providing basic education for all, are now spending greater sums on higher education, technical provision, vocational programs and adult training. In this book, the author questions the automatic value of any rise in the education budget. She examines the gap between the rhetoric and reality of education in Britain today, focusing on a quarter century of British government activity. The book is structured as follows: chapter one provides a brief overview of the current profile of education and of the recent changes; chapter two argues that the links between education and growth are not as direct as assumed; chapter three discusses vocational education policies and their failure; chapter four argues that business bureaucracies knew little about what the education system should provide; chapter five focuses on the issue of workplace training; chapter six examines the growth in universities and whether it can be explained by economic change and the need for higher skills; chapter seven looks at the results of this growth - an increasingly differentiated and hierarchical university sector and in financial crisis - and argues that the current expansion may actually be doing more harm than good; and the final chapter provides the conclusion. The chapters are: A truly world-beating industry: the growth of formal education; Elixir or snake oil? can education really deliver growth? ' A great idea for other people's children: the decline and fall of vocational education; Does business know best? Why worry about training; The tyranny of numbers and the growth of the modern university; Pyramids and payments: the higher education market; Conclusion.
Unearthing truths in duoethnographic method

Purpose – The purpose of this paper is to engage with challenges the authors encountered in duoethnographic inquiry, including questions about what it means to tell the truth, and the decisions the authors made about what stories to include and exclude. The focus is on the ethical challenges involved in duoethnography and the ways in which the authors chose, and or felt compelled to, overcome them. The authors provide an argument for the need of intimate, eclectic and open-ended inquiry-based research that poses questions, challenges dominant discourses and promotes a compositional methodology in which to explore lived the experience of participants. Design/methodology/approach – The authors’ own duoethnographic process, embedded in an anthropological hermeneutics (Ricoeur, 1991), within a mode of narrative inquiry, developed over a period of three to four months. The authors had a number of formal and informal conversations – some recorded and transcribed, others remembered and reflected on later in e-ma.
An enhanced algorithm for fair traffic conditioning in Differentiated Services networks

Fair bandwidth sharing among traffic flows with different characteristics in Differentiated Service (DiffServ) networks is the focus of the current research. This paper examines and enhances an algorithm developed to enforce fairness among disparate TCP flows in the assured forwarding (AF) service in DiffServ. equation based marking (EBM) was introduced (M. El-Gendy and K. Shin (2002)) to enforce fairness in AF by monitoring existing network conditions used in marking decisions. The estimation of packet losses by the algorithm is integral to marking. The loss rates of different connections were demonstrated to converge hence enforcing a fair marking regardless of the metrics of individual flows. In this paper, EBM is analyzed for fairness and enhanced by implementing a more efficient technique for loss rate estimation. Comparison is made between EBM and the enhanced technique with results showing appreciable improvements in the maintenance of fairness. Furthermore, a service definition required by QoS standards is met with the implementation of the additional algorithm to EBM.
Low-Rank Matrix Completion with Adversarial Missing Entries

We show that, so long as the number of missing entries in any row or column is bounded by a function of the dimension, rank, and incoherence of the matrix, nuclear norm minimization recovers the target matrix exactly. The range for which this guarantee holds is surprisingly large--in an $n\times n$ matrix of constant rank, there may be as many as $\Omega(n)$ entries missing in every row and column. Conversely, if only constantly many entries are missing in any row or column, then we may recover matrices of rank $\Omega(n)$. We also use adversarial matrix completion to give an algorithm for completing an order-$m$ symmetric low-rank tensor from its multilinear entries in time roughly proportional to the number of tensor entries. We apply our tensor completion algorithm to the problem of learning mixtures of product distributions over the hypercube, obtaining new algorithmic results. If the centers of the product distribution are linearly independent, then we recover distributions with as many as $\Omega(n)$ centers in polynomial time and sample complexity. In the general case, we recover distributions with as many as $\tilde\Omega(n)$ centers in quasi-polynomial time, answering an open problem of Feldman et al. (SIAM J. Comp.) for the special case of distributions with incoherent bias vectors.