Miracle-dz/UniFAR-FTUs huggingface dataset:
Laboratory Selection Quickly Erases Historical Differentiation

The roles of history, chance and selection have long been debated in evolutionary biology. Though uniform selection is expected to lead to convergent evolution between populations, contrasting histories and chance events might prevent them from attaining the same adaptive state, rendering evolution somewhat unpredictable. The predictability of evolution has been supported by several studies documenting repeatable adaptive radiations and convergence in both nature and laboratory. However, other studies suggest divergence among populations adapting to the same environment. Despite the relevance of this issue, empirical data is lacking for real-time adaptation of sexual populations with deeply divergent histories and ample standing genetic variation across fitness-related traits. Here we analyse the real-time evolutionary dynamics of Drosophila subobscura populations, previously differentiated along the European cline, when colonizing a new common environment. By analysing several life-history, physiological and morphological traits, we show that populations quickly converge to the same adaptive state through different evolutionary paths. In contrast with other studies, all analysed traits fully converged regardless of their association with fitness. Selection was able to erase the signature of history in highly differentiated populations after just a short number of generations, leading to consistent patterns of convergent evolution.
Lessons learned from 100 initial cases of laparoscopic liver surgery

Purpose Laparoscopic liver resection (LLR) is now widely accepted and is being increasingly performed. The present study describes our experience with LLR at a single center over an eight-year period. Methods This retrospective study enrolled 100 patients between October 2002 and February 2010. Forty-six benign lesions and 54 malignant lesions were included. The LLR performed included 58 pure laparoscopy procedures, 18 hand-assisted laparoscopy procedures and 24 hybrid technique procedures. Results The mean age of the patients was 57 years; among these patients, 31 were over 65 years of age. The mean operation time was 220 minutes. The overall morbidity was 11% and the mortality was zero. Among the 20 patients with simple hepatic cysts, 50% unexpectedly recurred. Among the 41 patients with hepatocellular carcinoma, 21 patients (51%) underwent preoperative radiofrequency ablation therapy or transarterial chemoembolization. During parenchymal-transection, 11 received blood transfusion. The width of the resection margins was under 0.5 cm in 11 cases (27%); 0.5 to 1 cm in 22 cases (54%) and over 1 cm in eight cases (12%). There was no port site seeding, but argon beam coagulation-induced tumor dissemination was observed in two cases. The overall two-year survival rate was 75%. Conclusion This study suggests that the applications for LLR can be gradually expanded when assuring that the safety and curability of LLR are equivalent to that of open liver resection.
Bond Liquidity Premia

Recent asset pricing models of limits to arbitrage emphasize the role of funding conditions faced by financial intermediaries. In the US, the repo market is the key funding market. Then, the premium of on-the-run U.S. Treasury bonds should share a common component with risk premia in other markets. This observation leads to the following identification strategy. We measure the value of funding liquidity from the cross-section of on-the-run premia by adding a liquidity factor to an arbitrage-free term structure model. As predicted, we find that funding liquidity explains the cross-section of risk premia. An increase in the value of liquidity predicts lower risk premia for on-the-run and off-the-run bonds but higher risk premia on LIBOR loans, swap contracts and corporate bonds. Moreover, the impact is large and pervasive through crisis and normal times. We check the interpretation of the liquidity factor. It varies with transaction costs, S&P500 valuation ratios and aggregate uncertainty. More importantly, the liquidity factor varies with narrow measures of monetary aggregates and measures of bank reserves. Overall, the results suggest that different securities serve, in part, and to varying degrees, to fulfill investors' uncertain future needs for cash depending on the ability of intermediaries to provide immediacy.
Ethnic Identity in Context of Ethnic Discrimination: When Does Gender and Other-Group Orientation Increase Risk for Depressive Symptoms for Immigrant-Origin Young Adults?

Objectives: Ethnic discrimination increases risk for depressive symptoms, but less is known about factors that influence the impact of this cultural challenge on psychological adjustment for immigrant-origin college students. Sociocultural identity development is especially relevant during emerging adulthood. Studies examining exacerbating or buffering impacts of ethnic identity have yielded mixed results. The current study examines conditions under which one aspect of ethnic identity, affirmation/belonging, moderates the impact of perceived ethnic discrimination stress on depressive symptoms. This was expected to vary by other-group orientation and gender, in accordance with rejection sensitivity theory. Method: A multicultural sample of 290 non-White immigrant-origin emerging adults (aged 18–25) from mixed cultural backgrounds and generational statuses attending a college in the Southeastern United States completed electronic self-report questionnaires. Results: More robust support was provided for social identity theory rather than rejection sensitivity theory: stronger affirmation/belonging was inversely associated with depressive symptoms across the sample, with a notable buffering impact for women. Trend-level results indicated a protective effect for those endorsing stronger affirmation/belonging paired with greater other-group orientation. Additionally, women with weaker affirmation/belonging demonstrated greater increased depressive symptoms compared to men with weaker affirmation/belonging. Conclusions: For this sample, social identity theory was relevant to the impact of affirmation/belonging on the relation between ethnic discrimination and depressive symptoms contingent on other-group orientation and gender. This finding underscores the importance of examining ethnic identity in a nuanced manner. Implications for these results extend to college counseling centers, where inclusion of sociocultural identity in case conceptualization would be useful.
Culotte stenting vs. TAP stenting for treatment of de-novo coronary bifurcation lesions with the need for side-branch stenting: the Bifurcations Bad Krozingen (BBK) II angiographic trial.

AIMS In percutaneous coronary intervention for de-novo coronary bifurcation lesions, the optimal technique for provisional side-branch stenting is still a matter of debate. We tested whether in this setting culotte stenting reduces the incidence of restenosis as compared with T-and-protrusion (TAP) stenting. METHODS AND RESULTS This trial included 300 patients with a coronary bifurcation lesion requiring a side-branch stent. Patients were randomly assigned to culotte stenting or TAP stenting using drug-eluting stents in a 1:1 fashion. Primary endpoint was maximal per cent diameter stenosis of the bifurcation lesion at 9-month angiographic follow-up. As clinical endpoints we assessed target lesion re-intervention (TLR) and target lesion failure (composite of cardiac death, target vessel myocardial infarction, and TLR). Angiographic follow-up was available in 91% of the patients. After culotte stenting, the maximum per cent diameter stenosis in the treated bifurcation lesion was 21 ± 20% as compared with 27 ± 25% after TAP stenting (P = 0.038). The respective corresponding binary restenosis rates were 6.5 and 17% (P = 0.006). The 1-year incidence of TLR was 6.0% after culotte stenting vs. 12.0% after T-stenting (P = 0.069). Target lesion failure occurred in 6.7% of the culotte group and in 12.0% of the TAP group (P = 0.11). Only one patient of the culotte group incurred a definite stent thrombosis during 1-year follow-up. CONCLUSIONS Compared with the TAP stenting, culotte stenting was associated with a significantly lower incidence of angiographic restenosis.
Anthropometric Variables and Somatotype of Young and Professional Male Basketball Players

Background: Determining somatic models and profiles in young athletes has recently become a fundamental element in selecting basketball playing positions. The aim of this study was to assess the relationship between the body build of young and adult elite male basketball players at different playing positions. Methods: Participants consisted of 35 young (age: 14.09 ± 0.30 years, n = 35) and 35 adult professional basketball players (age: 24.45 ± 5.40 years, n = 35) competing in elite leagues. The anthropometric characteristics assessed included body mass, body height, skinfolds, somatotypes, girths, and breadths. Results: The centers in both age groups were significantly taller and heavier (p < 0.001) compared to forwards and guards. The greatest difference between categories were in the guards’ personal height (from 169.36 to 186.68 = 17.32 cm). The guards from the professional team were closest in height to the forwards (difference = 7.17 cm) compared to young players where the difference between guards and forwards was 13.23 cm. Young competitors were more ectomorphic (2.12-3.75-4.17), while professional players were more mesomorphic (2.26-4.57-3.04). Significant criteria for center selection at professional level seems to be personal height and arm span ratio. Conclusions: The results indicate that the selection for basketball playing positions should include the analysis of body height and mass, shoulder breadth, humerus breadth, femur breadth and specifically for centers the difference between personal the height and arm span.
A Multifeature Tensor for Remote-Sensing Target Recognition

In remote-sensing image target recognition, the target or background object is usually transformed to a feature vector, such as a spectral feature vector. However, this kind of vector represents only one pixel of a remote-sensing image that considers the spectral information but ignores the spatial relationship of neighboring pixels (i.e., the local texture and structure). In this letter, we propose a new way to represent an image object as a multifeature tensor that encodes both the spectral and textural information (Gabor function) and then apply the support tensor machine for target recognition. A range of experiments demonstrates that the effectiveness of the proposed method can deliver a high and correct recognition rate with a small number of training samples.
Atmospheric light estimation using fog line vector for efficient defogging without color distortion

This paper presents an efficient defogging method with less color distortion. The proposed method consists of three steps: i) estimate atmospheric light using fog line vectors and fog-free reference image; ii) estimate transmission using fuzzy membership function; iii) refine the transmission using L1-Norm regularization, and obtain a defogged image based on fog model using the estimated the atmospheric light and the refined transmission. Experimental results show that the proposed method can effective remove fog components in the foggy image without color distortion.
Effects of Pilates and aqua fitness training on older adults’ physical functioning and quality of life

Abstract Study aim: To measure the effects of Pilates and aqua fitness training on functional fitness and quality of life in older individuals. Material and methods: A total of 54 participants (M = 66.4 ± 6.2 years) from a club for retired people in Eger, Hungary, were randomly assigned to 3 groups: one did Pilates 3 times/week (n = 22); one did aqua fitness 3 times/week (n = 17); and a control group (n = 15). The Fullerton Functional Fitness Test (FFFT) was used to measure functional fitness pre - and post-program. Quality of life was measured by WHO’s quality of life questionnaire (WHOQOL). Results: In the FFFT, significant improvement was found in 5 out of 7 variables: lower and upper body strength, lower body flexibility, physical mobility (especially dynamic balance), and aerobic endurance by the Pilates group. Shoulder flexibility improved significantly in the Aqua fitness group. Lower body strength improved in the control group. BMI did not change significantly in any of the groups. WHOQOL showed improvement in perception and autonomy in the Pilates group; sociability in the Aqua group. The between-subject analyses yielded a significant main effect of the experimental group F(1, 52) = 4367 (p < 0.001). Discussion: A 6-month intervention program is an appropriate tool to improve overall physical performance of healthy, inactive older adults, regardless of the type of exercise concerning Pilates or Aqua fitness, but might improve only some aspects of QOL. There is a strong need for well-designed intervention programs for the elderly.
Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy

NumbL, or Numb-like, is a close homologue of Numb, and is part of an evolutionary conserved protein family implicated in some important cellular processes. Numb is a protein involved in cell development, in cell adhesion and migration, in asymmetric cell division, and in targeting proteins for endocytosis and ubiquitination. NumbL exhibits some overlapping functions with Numb, but its role in tumorigenesis is not fully known. Here we showed that the downregulation of NumbL alone is sufficient to increase NICD nuclear translocation and induce Notch pathway activation. Furthermore, NumbL downregulation increases epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC)-related gene transcripts and CSC-like phenotypes, including an increase in the CSC-like pool. These data suggest that NumbL can act independently as a tumor suppressor gene. Furthermore, an absence of NumbL induces chemoresistance in tumor cells. An analysis of human tumors indicates that NumbL is downregulated in a variable percentage of human tumors, with lower levels of this gene correlated with worse prognosis in colon, breast and lung tumors. Therefore, NumbL can act as an independent tumor suppressor inhibiting the Notch pathway and regulating the cancer stem cell pool.
Duplicate question detection in stack overflow: A reproducibility study

Stack Overflow has become a fundamental element of developer toolset. Such influence increase has been accompanied by an effort from Stack Overflow community to keep the quality of its content. One of the problems which jeopardizes that quality is the continuous growth of duplicated questions. To solve this problem, prior works focused on automatically detecting duplicated questions. Two important solutions are DupPredictor and Dupe. Despite reporting significant results, both works do not provide their implementations publicly available, hindering subsequent works in scientific literature which rely on them. We executed an empirical study as a reproduction of DupPredictor and Dupe. Our results, not robust when attempted with different set of tools and data sets, show that the barriers to reproduce these approaches are high. Furthermore, when applied to more recent data, we observe a performance decay of our both reproductions in terms of recall-rate over time, as the number of questions increases. Our findings suggest that the subsequent works concerning detection of duplicated questions in Question and Answer communities require more investigation to assert their findings.
Operational definition of intrinsically unstructured protein sequences based on susceptibility to the 20S proteasome

Intrinsically unstructured proteins (IUPs), also known as natively unfolded proteins, lack well‐defined secondary and tertiary structure under physiological conditions. In recent years, growing experimental and theoretical evidence has accumulated, indicating that many entire proteins and protein sequences are unstructured under physiological conditions, and that they play significant roles in diverse cellular processes. Bioinformatic algorithms have been developed to identify such sequences in proteins for which structural data are lacking, but still generate substantial numbers of false positives and negatives. We describe here a simple and reliable in vitro assay for identifying IUP sequences based on their susceptibility to 20S proteasomal degradation. We show that 20S proteasomes digest IUP sequences, under conditions in which native, and even molten globule states, are resistant. Furthermore, we show that protein–protein interactions can protect IUPs against 20S proteasomal action. Taken together, our results thus suggest that the 20S proteasome degradation assay provides a powerful system for operational definition of IUPs. Proteins 2008. © 2007 Wiley‐Liss, Inc.
Management of Multi-Drive Powertrain for Full Electric Vehicle in Degraded Operating Conditions

This paper deals with the development of force splitting strategies to be used within the computation of the force reference in multi-drive electric powertrains. Under normal operating conditions the total force is divided between the drives according to a desired behavior for better performance or energy consumption. The proposed algorithms take into account possible malfunctions which may reduce the tractive force of one or more drives, thus affecting the output sharing principle. For a number of degraded working conditions, several correction strategies have been implemented, with the aim of minimizing the impact of drive anomalies on the vehicle's behavior and the driver's feeling.
Characterization Method for Electrothermal Model of Li-Ion Large Cells

Cell temperature is a key parameter in terms of ageing and discharge capacity. The objective of this paper is to present a reproducible method to characterize the thermal and the electrical parameters of a large cell used in an electric vehicle. A real electric vehicle lithium iron phosphate (LFP) cell is characterized thermally and electrically at 25 °C. The model temperature and voltage are then compared with the real cell using a high power WLTC (Worldwide harmonized Light duty driving Test Cycle) current cycle at 25°C ambient temperature.
PhyMet2: a database and toolkit for phylogenetic and metabolic analyses of methanogens

The vast biodiversity of the microbial world and how little is known about it, has already been revealed by extensive metagenomics analyses. Our rudimentary knowledge of microbes stems from difficulties concerning their isolation and culture in laboratory conditions, which is necessary for describing their phenotype, among other things, for biotechnological purposes. An important component of the understudied ecosystems is methanogens, archaea producing a potent greenhouse-effect gas methane. Therefore, we created PhyMet2 , the first database that combines descriptions of methanogens and their culturing conditions with genetic information. The database contains a set of utilities that facilitate interactive data browsing, data comparison, phylogeny exploration and searching for sequence homologues. The most unique feature of the database is the web server MethanoGram, which can be used to significantly reduce the time and cost of searching for the optimal culturing conditions of methanogens by predicting them based on 16S RNA sequences. The database will aid many researchers in exploring the world of methanogens and their applications in biotechnological processes. PhyMet2 with the MethanoGram predictor is available at http://metanogen.biotech. uni.wroc. pl.
Provenance management in Swift with implementation details.

The Swift parallel scripting language allows for the specification, execution and analysis of large-scale computations in parallel and distributed environments. It incorporates a data model for recording and querying provenance information. In this article we describe these capabilities and evaluate interoperability with other systems through the use of the Open Provenance Model. We describe Swift's provenance data model and compare it to the Open Provenance Model. We also describe and evaluate activities performed within the Third Provenance Challenge, which consisted of implementing a specific scientific workflow, capturing and recording provenance information of its execution, performing provenance queries, and exchanging provenance information with other systems. Finally, we propose improvements to both the Open Provenance Model and Swift's provenance system.
Developing Knowledge-Based Systems using the Semantic Web

The benefits of reuse have long been recognized in the knowledge engineering community where the dream of creating knowledge-based systems on-the-fly from libraries of reusable components is still to be fully realised. In this paper we present a two stage methodology for creating knowledge-based systems: first reusing domain knowledge by mapping it, where appropriate, to the requirements of a generic problem solver; and secondly using this mapped knowledge and the requirements of the problem solver to "drive" the acquisition of the additional knowledge it needs. For example, suppose we have available a knowledge-based systems which is composed of a propose-and-revise problem solver linked with an appropriate knowledge base/ontology from the elevator domain. Then to create a diagnostic knowledge-based systems in the same domain, we require to map relevant information from the elevator knowledge base/ontology, such as component information, to a diagnostic problem solver, and then to extend it with diagnostic information such as malfunctions, symptoms and repairs for each component. We have developed MAKTab, a Protege plug-in which supports both these steps and results in a composite knowledgebased systems which is executable. In the final section of this paper we discuss the issues involved in extending MAKTab so that it would be able to operate in the context of the (Semantic) Web. Here we use the idea of centralised mapping repositories and mapping composition. This work contributes to the vision of the Web, which contains components (both problem solvers and instantiated ontologies (knowledge bases)) that tools (like MAKTab) can use to create knowledge-based systems which subsequently can enhance the richness of the Web by providing yet further knowledge-based Web-services.
Online Spatial Normalization for Real-Time fMRI

Real-time functional magnetic resonance imaging (rtfMRI) is a recently emerged technique that demands fast data processing within a single repetition time (TR), such as a TR of 2 seconds. Data preprocessing in rtfMRI has rarely involved spatial normalization, which can not be accomplished in a short time period. However, spatial normalization may be critical for accurate functional localization in a stereotactic space and is an essential procedure for some emerging applications of rtfMRI. In this study, we introduced an online spatial normalization method that adopts a novel affine registration (AFR) procedure based on principal axes registration (PA) and Gauss-Newton optimization (GN) using the self-adaptive β parameter, termed PA-GN(β) AFR and nonlinear registration (NLR) based on discrete cosine transform (DCT). In AFR, PA provides an appropriate initial estimate of GN to induce the rapid convergence of GN. In addition, the β parameter, which relies on the change rate of cost function, is employed to self-adaptively adjust the iteration step of GN. The accuracy and performance of PA-GN(β) AFR were confirmed using both simulation and real data and compared with the traditional AFR. The appropriate cutoff frequency of the DCT basis function in NLR was determined to balance the accuracy and calculation load of the online spatial normalization. Finally, the validity of the online spatial normalization method was further demonstrated by brain activation in the rtfMRI data.