Miracle-dz/UniFAR-FTUs huggingface dataset:
The support mechanism of the young Foundation Seamounts inferred from bathymetry and gravity

SUMMARY The youngest volcanoes of the Foundation volcanic chain were built on a plate less than 5 Myr near the Pacific‐Antarctic ridge (PAR) axis. The progressive approach of the spreading ridge to the hotspot during the last 10 Myr resulted in the building of the edifices upon a progressively younger plate. Estimates of the effective elastic thickness, Te, using two independent methods show that the elastic thickness of the plate diminishes towards the spreading ridge, from 5‐3 km to 2‐0 km. The spatial variation of Te correlates with a significant change in both the morphology and the volume of the volcanoes, suggesting an important control of the elastic thickness on the volcanic processes. The reduction in Te also explains conveniently the reduction in the distance between the North and the South Systems, the double volcanic line that characterizes the young part of the Foundation chain, in the direction of young loading ages. The South System formed at the top of a flexural bulge created by the emplacement of the North System, the main volcanic line. The low Te estimate for the South System and the shape of the Bouguer anomalies confirm this model. The effective elastic thicknesses obtained in this study are well matched by isotherms between 200 ◦ C and 300 ◦ C and support the hypothesis of a weak plate. Three mechanisms possibly acted to lower the plate rigidity: Re-heating of a ‘normal’ plate by the hotspot (North System); local fracturing (South System) and the creation of a thin lithosphere at the PAR axis by the coupling of a hotspot and the ridge-related melting zones (near-ridge volcanoes).
Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity

Significance We show that autoimmunity, caused by conventional T cells expressing constitutively active MALT1 paracaspase, is triggered by cleavage of a single substrate, the RNA-binding protein Roquin-1. MALT1 translates graded TCR signal strength into binary cell fate decisions, as decreasing Roquin activities are associated with differential derepression of low- and high-affinity targets. As an example of this regulation, we find that Th17 differentiation requires high TCR strength, strongly reduced Roquin activity and the concomitant induction of the modulator of transcription, IκBNS, a high-affinity Roquin target. Together, we show that interfering with a distinct TCR strength integrating signaling pathway selectively mitigates T cell–driven immunopathology.
Nanoparticles in pancreatic cancer therapy: a detailed and elaborated review on patent literature

ABSTRACT Introduction Nanotechnology may open up new avenues for overcoming the challenges of pancreatic cancer therapy as a broad arsenal of anticancer medicines fail to realize their full therapeutic potential in pancreatic ductal adenocarcinoma due to the formation of multiple resistance mechanisms inside the tumor. Many studies have reported the successful use of various nano formulations in pancreatic cancer therapy. Areas covered This review covers all the major nanotechnology-based patent litrature available on renowned patent data bases like Patentscope and Espacenet, through the time period of 2007–2022. This is an entirely patent centric review, and it includes both clinical and non-clinical data available on nanotechnology-based therapeutics and diagnostic tools for pancreatic cancer. Expert opinion For the sake of understanding, the patents are categorized under various formulation-specific heads like metallic/non-metallic nanoparticles, polymeric nanoparticles, liposomes, carbon nanotubes, protein nanoparticles and liposomes. This distinguishes one specific nanoparticle type from another and makes this review a one-of-a-kind comprehensive patent compilation that has not been reported so far in the history of nanotechnological formulations in pancreatic cancer. GRAPHICAL ABSTRACTDifferent nanotechnology backed formulations and pancreatic cancer
Nocturnal Hypertension and Left Ventricular Diastolic Dysfunction in Patients With Diabetes With the Absence of Heart Failure: Prospective Cohort HSCAA Study

BACKGROUND: Diabetes is an important risk factor for heart failure (HF) and is associated with left ventricular (LV) diastolic dysfunction. However, diabetic comorbid conditions, such as nocturnal hypertension, as predictors of diastolic dysfunction are not known in the absence of an HF period. The present study was conducted as the longitudinal examination of the predictive value of nocturnal hypertension profiles on the progression of LV diastolic dysfunction in patients with and without diabetes without HF. METHODS: The subjects (154 diabetes and 268 nondiabetes) in the absence of HF were followed for 36.8±18.2 months. The relationships among the patterns of nocturnal hypertension and the outcome of LV diastolic dysfunction, defined as an increase in E/e′>14, were investigated in the patients with and without diabetes. RESULTS: The interaction effect of the diabetes status and the patterns of nocturnal hypertension on the hazard rate of the occurrence of E/e′>14 was statistically significant (P=0.017). Kaplan-Meier analysis results revealed that patients with diabetes with nondipper (P=0.021 versus dipper) and riser (P=0.006 versus dipper) had a greater risk for a diastolic dysfunction event. Furthermore, multivariable Cox proportional hazards analysis revealed that nondipper (hazard ratio, 4.56 [95% CI, 1.49–13.96]; P=0.007) and riser (hazard ratio, 3.89 [95% CI, 1.31–11.57]; P=0.014) patterns were associated with elevated risk of the outcome of LV diastolic dysfunction. In contrast, no similar significant associations were found in patients without diabetes. CONCLUSIONS: During the absence of HF periods, nocturnal hypertension is an important predictor for the progression of LV diastolic dysfunction in patients with diabetes.
Determination of age-specific reference intervals for selected serum and urinary biomarkers in elderly cats

Objectives Annual health screening is recommended in elderly cats to allow the early detection of conditions such as chronic kidney disease (CKD) and hyperthyroidism. Nevertheless, age-specific reference intervals (RIs) for renal and thyroid parameters in this population are lacking. The aim of this study was to determine age-specific RIs for selected serum and urine biomarkers related to CKD and hyperthyroidism, namely serum creatinine (sCr), symmetric dimethylarginine (SDMA), phosphate (P), total calcium (tCa), total thyroxine (TT4), urinary protein:creatinine ratio (UPC) and urine specific gravity (USG). These RIs were established for elderly cats (aged ⩾7 years) in general, as well as for mature adult cats (aged 7–10 years) and senior cats (aged >10 years) separately. Methods A prospective study was conducted on client-owned cats aged ⩾7 years and considered healthy by their owners. The cats were screened to rule out metabolic and systemic diseases by means of a thorough history, complete physical examination, blood examination and urinalysis. The data from 206 healthy elderly cats (134 mature adult and 72 senior cats) were included. Age-appropriate RIs were determined following the guidelines of the American Society of Veterinary Clinical Pathology and compared with existing laboratory RIs. Results Clinically relevant differences between the age-specific RI and the laboratory RI were found for several variables. Compared with the laboratory RI, the upper limit of the RI for cats aged ⩾7 years was lower for sCr, TT4 and P, and higher for SDMA. The lower limit of the age-appropriate RI was lower for USG. The new RI was almost identical to the existing laboratory RI for tCa and UPC. Conclusions and relevance Using age-specific RIs for renal and thyroid biomarkers in mature adult and senior cats has important clinical consequences for the interpretation of health screening results in elderly cats. This confirms the need to adapt laboratory RIs to the specific animal population for which the RI will be used.
Seismic behaviour of gravity-type quay wall backfilled with granular treated soil

含水比が高い軟弱な粘土・シルト系の土を改良して比較的高強度な粒状体（造粒固化土）を作製する技術がある。 一般的な地盤材料に比べて造粒固化土は軽量であり，例えば重力式ケーソン岸壁背後の埋立材に適用すれば，地震時におけるケーソンの水平変位量を低減できる。 本研究では，岸壁の振動特性を詳細に調べ変位低減のメカニズムを明らかにすることを目的として，動的変形特性試験および動的遠心模型実験を実施した。 模型実験では，ケーソンへ作用する土圧を計測し，その土圧と振動特性の関係を調べた。 その結果，造粒固化土で形成された地盤からケーソンへ作用する地震時土圧は小さく，これを主要因として変位量が低減されることを確認した。
The B1 H+-ATPase (Atp6v1b1) Subunit in Non–Type A Intercalated Cells is Required for Driving Pendrin Activity and the Renal Defense Against Alkalosis

Visual Abstract Significance Statement In the kidney, the B1 H+-ATPase subunit is mostly expressed in intercalated cells (IC). Its importance in acid-secreting type A ICs is evident in patients with inborn distal renal tubular acidosis and ATP6V1B1 mutations. However, the protein is also highly expressed in alkali-secreting non–type A ICs where its function is incompletely understood. We demonstrate in Atp6v1b1 knock out mice that the B1 subunit is critical for the renal response to defend against alkalosis during an alkali load or chronic furosemide treatment. These findings highlight the importance of non–type A ICs in maintaining acid–base balance in response to metabolic challenges or commonly used diuretics. Background Non–type A ICs in the collecting duct system express the luminal Cl−/HCO3− exchanger pendrin and apical and/or basolateral H+-ATPases containing the B1 subunit isoform. Non–type A ICs excrete bicarbonate during metabolic alkalosis. Mutations in the B1 subunit (ATP6V1B1) cause distal renal tubular acidosis due to its role in acid secretory type A ICs. The function of B1 in non–type A ICs has remained elusive. Methods We examined the responses of Atp6v1b1−/− and Atp6v1b1+/+ mice to an alkali load and to chronic treatment with furosemide. Results An alkali load or 1 week of furosemide resulted in a more pronounced hypokalemic alkalosis in male ATP6v1b1−/− versus Atp6v1b1+/+ mice that could not be compensated by respiration. Total pendrin expression and activity in non–type A ICs of ex vivo microperfused cortical collecting ducts were reduced, and β2-adrenergic stimulation of pendrin activity was blunted in ATP6v1b1−/− mice. Basolateral H+-ATPase activity was strongly reduced, although the basolateral expression of the B2 isoform was increased. Ligation assays for H+-ATPase subunits indicated impaired assembly of V0 and V1 H+-ATPase domains. During chronic furosemide treatment, ATP6v1b1−/− mice also showed polyuria and hyperchloremia versus Atp6v1b1+/+. The expression of pendrin, the water channel AQP2, and subunits of the epithelial sodium channel ENaC were reduced. Conclusions Our data demonstrate a critical role of H+-ATPases in non–type A ICs function protecting against alkalosis and reveal a hitherto unrecognized need of basolateral B1 isoform for a proper H+-ATPase complexes assembly and ability to be stimulated.
Peri‐operative decisions about cardiopulmonary resuscitation among adults as reported to the 7th National Audit Project of the Royal College of Anaesthetists

Current guidance recommends that, in most circumstances, cardiopulmonary resuscitation should be attempted when cardiac arrest occurs during anaesthesia, and when a patient has a pre‐existing ‘do not attempt cardiopulmonary resuscitation’ recommendation, this should be suspended. How this guidance is translated into everyday clinical practice in the UK is currently unknown. Here, as part of the 7th National Audit Project of the Royal College of Anaesthetists, we have: assessed the rates of pre‐operative ‘do not attempt cardiopulmonary resuscitation’ recommendations via an activity survey of all cases undertaken by anaesthetists over four days in each participating site; and analysed our one‐year case registry of peri‐operative cardiac arrests to understand the rates of cardiac arrest in patients who had ‘do not attempt cardiopulmonary resuscitation’ decisions pre‐operatively. In the activity survey, among 20,717 adults (aged > 18 y) undergoing surgery, 595 (3%) had a ‘do not attempt cardiopulmonary resuscitation’ recommendation pre‐operatively, of which less than a third (175, 29%) were suspended. Of the 881 peri‐operative cardiac arrest reports, 54 (6%) patients had a ‘do not attempt cardiopulmonary resuscitation’ recommendation made pre‐operatively and of these 38 (70%) had a clinical frailty scale score ≥ 5. Just under half (25, 46%) of these ‘do not attempt cardiopulmonary resuscitation’ recommendations were formally suspended at the time of anaesthesia and surgery. One in five of these patients with a ‘do not attempt cardiopulmonary resuscitation’ recommendation who had a cardiac arrest survived to leave hospital and of the seven patients with documented modified Rankin Scale scores before and after cardiac arrest, four remained the same and three had worse scores. Very few patients who had a pre‐existing ‘do not attempt cardiopulmonary resuscitation’ recommendation had a peri‐operative cardiac arrest, and when cardiac arrest did occur, return of spontaneous circulation was achieved in 57%, although > 50% of these patients subsequently died before discharge from hospital.
Lower limb muscle activity during first and second tennis serves: a comparison of three surface electromyography normalisation methods.

We assessed lower limb muscle activity during the execution of first and second tennis serves, exploring whether the extent of these differences is influenced by the chosen method for normalising surface electromyography (EMG) data. Ten male competitive tennis players first completed three rounds of maximal isometric voluntary contractions (MVC) of knee extensors and plantar flexors for the left (front) and right (back) leg separately, and three squat jumps. Afterward, they executed ten first and ten-second serves. Surface EMG activity of four lower limb muscles (vastus lateralis, rectus femoris, gastrocnemius lateralis, and soleus muscles) on each leg was recorded and normalised in three different ways: to MVC; to peak/maximal activity measured during squat jump; and to the actual serve. For the rectus femoris and soleus muscles of the left leg, and the gastrocnemius lateralis and soleus muscles of the right leg, EMG amplitude differed significantly between normalisation techniques (P ≤ 0.012). All muscles showed greater activity during the first serve, although this difference was only statistically significant for the right vastus lateralis muscle (P = 0.014). In conclusion, the EMG normalisation method selected may offer similar information when comparing first and second serve, at least for leg muscles studied here.
Angioimmunoblastic T‐cell lymphoma and Kaposi sarcoma: A fortuitous collision?

Follicular helper T‐cell (TFH) lymphoma of the angioimmunoblastic‐type (AITL), one of the most prevalent T‐cell lymphomas, typically encompasses proliferation of high endothelial venules and Epstein–Barr virus‐positive immunoblasts, but neither infection with HHV8 nor association with Kaposi's sarcoma (KS) have been described. The aims of this study are to characterise the association between AITL and HHV8 infection or KS.
Exploring the challenges of public health nurses in the management of infertility in Northern Ghana: a qualitative descriptive study

Objective To explore the challenges public health nurses (PNHs) face in managing infertility in rural settings of the Talensi and Nabdam districts in the Upper East Region of Ghana. Design The study adopted a qualitative descriptive design approach where PHNs who worked in rural settings were interviewed using a semistructured interview guide. Thematic analysis was employed to analyse the data. Setting Primary healthcare setting in the Upper East Region of Ghana. Participants The study participants were 15 PHNs working in primary health centres with a mean age of 36.9 years (SD=6.40). Results This study revealed that couples with infertility issues face challenges in seeking care for their condition. The challenges expressed by the participants that affect individual and couples’ access to infertility care were (1) lack of material and human resources, (2) lack of specialists and guides for infertility treatment and (3) inadequate and inconsiderate communication. Conclusion This study provides evidence of the challenges experienced by PHNs in managing infertility among couples. Adequate measures are therefore required to ameliorate these challenges to improve care provision for couples with infertility.
Managing oral biofilms to avoid enamel demineralization during fixed orthodontic treatment

Enamel demineralization represents the most prevalent complication arising from fixed orthodontic treatment. Its main etiology is the development of cariogenic biofilms formed around orthodontic appliances. Ordinarily, oral biofilms exist in a dynamic equilibrium with the host's defense mechanisms. However, the equilibrium can be disrupted by environmental changes, such as the introduction of a fixed orthodontic appliance, resulting in a shift in the biofilm’s microbial composition from non-pathogenic to pathogenic. This alteration leads to an increased prevalence of cariogenic bacteria, notably mutans streptococci, within the biofilm. This article examines the relationships between oral biofilms and orthodontic appliances, with a particular focus on strategies for effectively managing oral biofilms to mitigate enamel demineralization around orthodontic appliances.
Factors affecting hesitancy toward COVID-19 vaccine booster doses in Canada: a cross-national survey

Objective COVID-19 transmission, emergence of variants of concern, and weakened immunity have led to recommended vaccine booster doses for COVID-19. Vaccine hesitancy challenges broad immunization coverage. We deployed a cross-national survey to investigate knowledge, beliefs, and behaviours toward continued COVID-19 vaccination. Methods We administered a national, cross-sectional online survey among adults in Canada between March 16 and March 26, 2022. We utilized descriptive statistics to summarize our sample, and tested for demographic differences, perceptions of vaccine effectiveness, recommended doses, and trust in decisions, using the Rao-Scott correction for weighted chi-squared tests. Multivariable logistic regression was adjusted for relevant covariates to identify sociodemographic factors and beliefs associated with vaccine hesitancy. Results We collected 2202 completed questionnaires. Lower education status (high school: odds ratio (OR) 1.90, 95% confidence interval (CI) 1.29, 2.81) and having children (OR 1.89, CI 1.39, 2.57) were associated with increased odds of experiencing hesitancy toward a booster dose, while higher income ($100,000–$149,999: OR 0.60, CI 0.39, 0.91; $150,000 or more: OR 0.49, CI 0.29, 0.82) was associated with decreased odds. Disbelief in vaccine effectiveness (against infection: OR 3.69, CI 1.98, 6.90; serious illness: OR 3.15, CI 1.69, 5.86), disagreeing with government decision-making (somewhat disagree: OR 2.70, CI 1.38, 5.29; strongly disagree: OR 4.62, CI 2.20, 9.7), and beliefs in over-vaccinating (OR 2.07, CI 1.53, 2.80) were found associated with booster dose hesitancy. Conclusion COVID-19 vaccine hesitancy may develop or increase regarding subsequent vaccines. Our findings indicate factors to consider when targeting vaccine-hesitant populations. Supplementary Information The online version contains supplementary material available at 10.17269/s41997-023-00823-z.
High-efficiency high-NA metalens designed by maximizing the efficiency limit

Theoretical bounds are commonly used to assess the limitations of photonic design. Here we introduce a more active way to use theoretical bounds, integrating them into part of the design process and identifying optimal system parameters that maximize the efficiency limit itself. As an example, we consider wide-field-of-view high-numerical-aperture metalenses, which can be used for high-resolution imaging in microscopy and endoscopy, but no existing design has achieved a high efficiency. By choosing aperture sizes to maximize an efficiency bound, setting the thickness according to a thickness bound, and then performing inverse design, we come up with high-numerical-aperture (NA = 0.9) metalens designs with record-high 98% transmission efficiency and 92% Strehl ratio across all incident angles within a 60-deg field of view, reaching the maximized bound. This maximizing-efficiency-limit approach applies to any multi-channel system and can help a wide range of optical devices reach their highest possible performance.
A note on estimating the dimension from a random geometric graph

Let $G_n$ be a random geometric graph with vertex set $[n]$ based on $n$ i.i. d. \ random vectors $X_1,\ldots,X_n$ drawn from an unknown density $f$ on $\R^d$. An edge $(i,j)$ is present when $\|X_i -X_j\| \le r_n$, for a given threshold $r_n$ possibly depending upon $n$, where $\| \cdot \|$ denotes Euclidean distance. We study the problem of estimating the dimension $d$ of the underlying space when we have access to the adjacency matrix of the graph but do not know $r_n$ or the vectors $X_i$. The main result of the paper is that there exists an estimator of $d$ that converges to $d$ in probability as $n \to \infty$ for all densities with $\int f^5<\infty$ whenever $n^{3/2} r_n^d \to \infty$ and $r_n = o(1)$. The conditions allow very sparse graphs since when $n^{3/2} r_n^d \to 0$, the graph contains isolated edges only, with high probability. We also show that, without any condition on the density, a consistent estimator of $d$ exists when $n r_n^d \to \infty$ and $r_n = o(1)$.
Ten issues of NetGPT

With the rapid development and application of foundation models (FMs), it is foreseeable that FMs will play an important role in future wireless communications. As current Artificial Intelligence (AI) algorithms applied in wireless networks are dedicated models that aim for different neural network architectures and objectives, drawbacks in aspects of generality, performance gain, management, collaboration, etc. need to be conquered. In this paper, we define NetGPT (Network Generative Pre-trained Transformer) -- the foundation models for wireless communications, and summarize ten issues regarding design and application of NetGPT.
Enhancing Summarization Performance through Transformer-Based Prompt Engineering in Automated Medical Reporting

Customized medical prompts enable Large Language Models (LLM) to effectively address medical dialogue summarization. The process of medical reporting is often time-consuming for healthcare professionals. Implementing medical dialogue summarization techniques presents a viable solution to alleviate this time constraint by generating automated medical reports. The effectiveness of LLMs in this process is significantly influenced by the formulation of the prompt, which plays a crucial role in determining the quality and relevance of the generated reports. In this research, we used a combination of two distinct prompting strategies, known as shot prompting and pattern prompting to enhance the performance of automated medical reporting. The evaluation of the automated medical reports is carried out using the ROUGE score and a human evaluation with the help of an expert panel. The two-shot prompting approach in combination with scope and domain context outperforms other methods and achieves the highest score when compared to the human reference set by a general practitioner. However, the automated reports are approximately twice as long as the human references, due to the addition of both redundant and relevant statements that are added to the report.