Miracle-dz/UniFAR-FTUs huggingface dataset:
Endometrial carcinosarcoma

Endometrial carcinosarcoma is a rare and aggressive high-grade endometrial carcinoma with secondary sarcomatous trans-differentiation (conversion theory). The clinical presentation and diagnostic work-up roughly align with those of the more common endometrioid counterpart, although endometrial carcinosarcoma is more frequently diagnosed at an advanced stage. Endometrial carcinosarcoma is not a single entity but encompasses different histological subtypes, depending on the type of carcinomatous and sarcomatous elements. The majority of endometrial carcinosarcomas are characterized by p53 abnormalities. The proportion of POLE and microsatellite instablity-high (MSI-H) is directly related to the epithelial component, being approximately 25% and 3% in endometrioid and non-endometrioid components. The management of non-metastatic disease is based on a multimodal approach with optimal surgery followed by (concomitant or sequential) chemotherapy and radiotherapy, even for early stages. Palliative chemotherapy is recommended in the metastatic or recurrent setting, with carboplatin/paclitaxel doublet being the first-line regimen. Although the introduction of immunotherapy plus/minus a tyrosine kinase inhibitor shifted the paradigm of treatment of patients with recurrent endometrial cancer, patients with endometrial carcinosarcoma were excluded from most studies evaluating single-agent immunotherapy or the combination. However, the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) approved the use of pembrolizumab and lenvatinib in endometrial cancer (all histotypes) after progression on chemotherapy and single-agent immunotherapy in MSI-H cancers. In the era of precision medicine, emerging knowledge on molecular endometrial carcinosarcoma is opening new promising therapeutic options for more personalized treatment. The present review outlines state-of-the-art knowledge and future directions for patients with endometrial carcinosarcoma.
Emerging platform business models among the European electric utilities

The European energy sector is under a rapid change in business models due to the energy and digital transformations. The implications of these transformations are emerging platform business models among electric utilities and emerging electricity value chain in the energy sector. The study of platform business models among electric utilities is important, because they integrate the sector’s value chain and determine the transformations of the energy sector. In this paper, the current platform business models managed by electric utilities are analysed empirically and theoretically. The analysis covers 26 European electric utilities. The analysis aims to identify the classes of the platform business models for electric utilities. As a result, 28 digital platforms are identified and grouped into 9 business model classes. This paper examines how the electric utilities have employed novel business models. It provides evidence that, in the face of energy and digital transformations, the electric utilities are the key players in digital platform implementation in Europe.
A neurocognitive account of attentional control theory: how does trait anxiety affect the brain’s attentional networks?

ABSTRACT Attentional control theory (ACT) was proposed to account for trait anxiety’s effects on cognitive performance. According to ACT, impaired processing efficiency in high anxiety is mediated through inefficient executive processes that are needed for effective attentional control. Here we review the central assumptions and predictions of ACT within the context of more recent empirical evidence from neuroimaging studies. We then attempt to provide an account of ACT within a framework of the relevant cognitive processes and their associated neural mechanisms and networks, particularly the fronto-parietal, cingular-opercula, and default mode networks. Future research directions, including whether a neuroscience-informed model of ACT can provide a platform for novel neurocognitive intervention for anxiety, are also discussed.
Comparison of transumbilical and periumbilical median incisions in ovarian cancer surgery

Objective: The umbilicus is traditionally circumvented while performing a vertical midline abdominal incision. There is a gap in knowledge pertaining to avoiding the umbilicus. Our aim was to investigate whether a transumbilical (TU) or periumbilical (PU) midline incision conferred any advantage to the patient. Material and Methods: This was a retrospective cohort study of patients undergoing ovarian cancer surgery with a midline incision, from the pubic tubercle to the xiphoid. All surgery was performed by the same team of gyneacological oncologists. Patients were classified into two groups according to the midline incision used, TU or PU. The primary endpoint was the incision wound complication rate. Results: TU and PU midline incisions were performed in 54 and 68 patients, respectively. There were no differences between the two groups in terms of patient characteristics and operative details. The two groups had comparable rates of complications, including wound infection (7.4% vs. 10.3%, p=0.75), deep surgical site infection (11.1% vs. 4.4%, p=0.18), evisceration (3.7% vs. 4.4%, p=0.99) and incisional hernia (33.3% vs. 33.8%, p=0.99). Conclusion: Our findings suggest that circumventing the umbilicus during laparotomy did not have any advantage. Future prospective randomized trials are warranted to validate this finding.
Assessment of unexplored isoconversional methods to predict epoxy-based composite curing under arbitrary thermal histories

The mass manufacturing of composite products is hindered by long curing times, and composite manufacturers demand shorter curing cycles while keeping material properties. This requires reliable methods to predict the curing kinetics of each resin formulation. Isoconversional methods are easy to implement and able to deal with complex processes. However, scientists still limit their isoconversional predictions of curing degree to isothermal or constant heating programs. In this study, we perform combined dynamic and isothermal DSC measurements for two different commercial epoxies for aerospace applications (M18 and VTC401). Based on the isoconversional kinetic analysis, we show the feasibility of predicting the evolution of an epoxy resin cure for an arbitrary and complex temperature program using two different unexplored methods for this purpose. Because of the versatility of both prediction methods, they are especially suited to deal with actual conditions in industrial processes. The proposed approach is validated experimentally by comparing predictions against the curing degree of these epoxies during a temperature program that comprises isothermal and dynamic stages. These reliable and straightforward predictions open the door to optimize curing times and increase productivity in composites.
The influence of jumping performance and coordination on the spike ability of young volleyball athletes

Background and Study Aim. Spike is the most important techniques to be mastered due to its big impacts to volleyball match. There is still lack of study to evaluate and discusses how the role of jumping performance and coordination in volleyball could affect spike ability. The purpose of this study was to determine the influence of these variables on spike ability. Material and Methods. This study used a quantitative descriptive method, involved 42 participants (20 men and 22 women). The jump performance was measured using MyJump 2 application which can measure flight time, force, jump height, jumping power and speed based on free-arm jumping method. Then, the measurement of coordination was done using an alternative hand wall test. Spike ability is shown by the results of the hit and spike performance. Spike performance was based on The Volleyball Test Skills for Smasher. For spike performance, data collection is based on observations from five phases of spike movement; i) Initial posture; ii) Initial Motion; iii) Motion of Appeal; iv) Advanced Motion; v) Placement of the ball, using the scoring points 1-4. All the data was analyzed using descriptive statistics and Pearson Correlation. Results. The results of the study show that in the perspective of gender differences, almost all variables had significant difference between men and women on flight time (0.028 < 0.05), force (0.001 < 0.01), jump height (0.040 < 0). 0.05), strength (0.001 < 0.01), and speed (0.028 < 0.05), coupled with coordination (0.003 < 0.01), hit results (0.181 > 0.05), and spike performance (0.216 > 0.05). Meanwhile, the relationship between variables were found to be significant (p-value < 0.01) on the five jumping performance variables. Another significant correlation obtained from the results of calculations between coordination and jump height (0.033 < 0.05), coordination with strength (0.044 < 0.05), coordination with spike hitting results was significant (0.003 < 0.01). Instead of them, relationship between one and another was not found significant relationship (p-value > 0.05). Conclusions. Coaches can use the information in this study as a guideline to develop training program to improve their athletes effectiveness in spiking.
6-GHz, Kerr-lens mode-locked Yb:Lu 2 O 3 ceramic laser for comb-resolved broadband spectroscopy

A laser diode (LD)-pumped, 6-GHz repetition rate, ytterbium (Yb)-doped Lu2O3 ceramic Kerr-lens mode-locked laser is described. A bow-tie ring cavity enabled the generation of femtosecond pulses centered at a wavelength of 1076 nm with an average power of 10 mW. The pulse duration after an amplifier was 161 fs whereas the transform-limited pulse duration directly from the oscillator was 148 fs. The repetition frequency was sufficiently high for each longitudinal mode to be spectrally resolved by a commercially available optical spectrum analyzer. The developed laser was successfully applied to the absorption spectroscopy of metastable helium4 and demonstrated the suitability of the system as a source for comb-resolved broadband spectroscopy.
Transcriptomic Analysis Reveals That Retinal Neuromodulation Is a Relevant Mechanism in the Neuroprotective Effect of Sitagliptin in an Experimental Model of Diabetic Retinopathy

Synaptic dysfunction and neuronal damage have been extensively associated with diabetic retinopathy (DR). Our group evidenced that chronic hyperglycemia reduces the retinal expression of presynaptic proteins, which are crucial for proper synaptic function. The aim of the study was to explore the effect of topically administered sitagliptin, an inhibitor of the enzyme dipeptidyl peptidase-4, on the retinal expression patterns of an experimental model of DR. Transcriptome analysis was performed, comparing the retinas of 10 diabetic (db/db) mice randomly treated with sitagliptin eye drops (10 mg/mL) twice daily and the retinas of 10 additional db/db mice that received vehicle eye drops. Ten non-diabetic mice (db/+) were used as a control group. The Gene Ontology (GO) and Reactome databases were used to perform the gene set enrichment analysis (GSEA) in order to explore the most enriched biological pathways among the groups. The most differentiated genes of these pathways were validated through quantitative RT-PCR. Transcriptome analysis revealed that sitagliptin eye drops have a significant effect on retinal expression patterns and that neurotransmission is the most enriched biological process. Our study evidenced enriched pathways that contain genes involved in membrane trafficking, transmission across chemical synapses, vesicle-mediated transport, neurotransmitter receptors and postsynaptic signal transmission with negative regulation of signaling as a consequence of neuroprotector treatment with sitagliptin. This improves the modulation of the macromolecule biosynthetic process with positive regulation of cell communication, which provides beneficial effects for the neuronal metabolism. This study suggests that topical administration of sitagliptin ameliorates the abnormalities on presynaptic and postsynaptic signal transmission during experimental DR and that this improvement is one of the main mechanisms behind the previously demonstrated beneficial effects.
Anti- and Pro-Oxidant Activity of Polyphenols Extracts of Syrah and Chardonnay Grapevine Pomaces on Melanoma Cancer Cells

Simple Summary In this paper the phenolic composition of Syrah and Chardonnay grape pomaces was studied to assess their antioxidant and prooxidant properties, and their effect on melanoma cancer cells. Abstract The phenolic composition of Syrah and Chardonnay grape pomaces was studied to assess their antioxidant and prooxidant properties. Polyphenols were extracted by a "green" hydroalcoholic solvent (ethanol/water 1:1 v/v), and a detailed chemical and electrochemical characterization of the phenolic compounds was performed. The antioxidant and prooxidant capacity of the pomace was first studied by cyclic voltammetry (CV) and other reference analytical assays, then with biological tests on B16F10 metastatic melanoma cancer cells. Electrochemical data showed that, when a +0.5 V potential was applied, a low to moderate antioxidant capacity was observed. MTT test showed an increasing viability of melanoma cells, after treatments at low concentration (up to 100 μg/mL) and for a short time (6 h), but when cells were treated with higher doses of extract (≥250 μg/mL for 12/24 h), their viability decreased from 25 to 50% vs. control, depending on treatment time, dose, and extract origin. A stronger prooxidant activity resulted when 250 μg/mL of extract was combined with non-toxic doses of H2O2; this activity was correlated with the presence of copper in the extracts. This study shows the potential of winemaking by-products and suggests the opportunity to exploit them for the production of cosmeceuticals, or for combined therapies with approved anticancer drugs.
Properties of Table Tennis Blade from Sorghum Bagasse Particleboard Bonded with Maleic Acid Adhesive at Different Pressing Temperatures and Times

This physical and mechanical properties of a table tennis blade made from sorghum bagasse particleboard (TTBSB-particleboard) bonded maleic acid adhesive was investigated under pressing temperature and time variations. The TTBSB-particleboard was produced via a two-stage process in this study. A pressing temperature of 170–200 °C was used to prepare the first stage for 10 min. Following this, the second stage of the TTBSB-particleboard was produced with a different pressing time of 5–20 min. The TTBSB-particleboard had a specified target density of 0.6 g/cm3 and a size of 30 cm × 30 cm × 0.6 cm, respectively. For references concerning the tested quality of TTBSB-particleboard, the JIS A 5908-2003 standard has been used. For comparison, the commercial blades of Yuguan Wooden 1011 and Donic Original Carbo Speed were tested under the same conditions. The quality of the TTBSB-particleboard was successfully enhanced by increasing the pressing temperature (170 to 200 °C) and time (5 to 20 min). As a result, the pressing condition of 200 °C and 20 min were effective in this study. The TTBSB-particleboard in this study has a greater weight than the commercial blades of Yuguan and Donic. However, the TTBSB-particleboard in this study had a ball rebound comparable to that of the Donic blade.
Echocardiographic estimation of pulmonary vascular resistance in advanced lung disease

Abstract Noninvasive assessment of pulmonary hemodynamics is often performed by echocardiographic estimation of the pulmonary artery systolic pressure (ePASP), despite limitations in the advanced lung disease population. Other noninvasive hemodynamic variables, such as echocardiographic pulmonary vascular resistance (ePVR), have not been studied in this population. We performed a retrospective analysis of 147 advanced lung disease patients who received both echocardiography and right heart catheterization for lung transplant evaluation. The ePVR was estimated by four previously described equations. Noninvasive and invasive hemodynamic parameters were compared in terms of correlation, agreement, and accuracy. The ePVR models strongly correlated with invasively determined PVR and had good accuracy with biases of <1 Wood units (WU), although with moderate precision and wide 95% limits of agreement varying from 5.9 to 7.8 Wood units. The ePVR models were accurate to within 1.9 WU in over 75% of patients. In comparison to the ePASP, ePVR models performed similarly in terms of correlation, accuracy, and precision when estimating invasive hemodynamics. In screening for pulmonary hypertension, ePVR models had equivalent testing characteristics to the ePASP. Mid‐systolic notching of the right ventricular outflow tract Doppler signal identified a subgroup of 11 patients (7%) with significantly elevated PVR and mean pulmonary artery pressures without relying on the acquisition of a tricuspid regurgitation signal. Analysis of ePVR and determination of the notching pattern of the right ventricular outflow tract Doppler flow velocity envelope provide reliable insights into hemodynamics in advanced lung disease patients, although limitations in precision exist.
Adaptive two-time-scale tracking filter for target acceleration estimation

A critical phase during air-to-air interception is the homing phase. It is characterized by a short time to go and low bearing rates on the homing path. The phase is critical because any misconception with respect to the target maneuver may result in a substantial miss distance. This is essentially due to the lack of time to perform path corrections when the target produces a collision course error by an evasive maneuver. The estimation of the target acceleration is therefore crucial to the design of guidance laws that allow a fast response to target maneuvers. There are, however, severe problems associated with the synthesis of target trackers for air-to-air missiles. These problems include the lack of observability, modeling errors, and the restriction of the computation time due to high sampling rates. In this paper, a new tracking filter is presented that copes with the problems just mentioned. It is based on the time scale separation inherent in the tracking dynamics. In conjunction with a simple adaption scheme, this filter is able to track a large class of target maneuvers in a computationally efficient manner.
Quantum-Solving Algorithm for d’Alembert Solutions of the Wave Equation

When faced with a quantum-solving problem for partial differential equations, people usually transform such problems into Hamiltonian simulation problems or quantum-solving problems for linear equation systems. In this paper, we propose a third approach to solving partial differential equations that differs from the two approaches. By using the duality quantum algorithm, we construct a quantum-solving algorithm for solving the first-order wave equation, which represents a typical class of partial differential equations. Numerical results of the quantum circuit have high precision consistency with the theoretical d’Alembert solution. Then the routine is applied to the wave equation with either a dissipation or dispersion term. As shown by complexity analysis for all these cases of the wave equation, our algorithm has a quadratic acceleration for each iteration compared to the classical algorithm.
Raman Study of the Diamond to Graphite Transition Induced by the Single Femtosecond Laser Pulse on the (111) Face

The use of the ultrafast pulse is the current trend in laser processing many materials, including diamonds. Recently, the orientation of the irradiated crystal face was shown to play a crucial role in the diamond to graphite transition process. Here, we develop this approach and explore the nanostructure of the sp2 phase, and the structural perfection of the graphite produced. The single pulse of the third harmonic of a Ti:sapphire laser (100 fs, 266 nm) was used to study the process of producing highly oriented graphite (HOG) layers on the (111) surface of a diamond monocrystal. The laser fluence dependence on ablated crater depth was analyzed, and three different regimes of laser-induced diamond graphitization are discussed, namely: nonablative graphitization, customary ablative graphitization, and bulk graphitization. The structure of the graphitized material was investigated by confocal Raman spectroscopy. A clear correlation was found between laser ablation regimes and sp2 phase structure. The main types of structural defects that disrupt the HOG formation both at low and high laser fluencies were determined by Raman spectroscopy. The patterns revealed give optimal laser fluence for the production of perfect graphite spots on the diamond surface.
On the linear partial $q$-difference equation of general type

Introduction. In a paper published some time agof the author defined the linear partial g-difference equation and examined a class of such equations. The general methods employed were those introduced by Birkhofft in studying the linear ordinary difference equation. It is our purpose here to investigate the general problem of the partial ^-difference equation, to which the methods of Birkhoff, based primarily on iteration, are not applicable. We propose to establish existence theorems by direct convergence proofs. The equation considered is§
The Effect of Games Simulation in Improving Secondary Students' Academic Performance

The main purpose of the study was to find out the effect of simulation games as an intervention program in teaching-learning economics to improve students' academic performance. The study adopts a mixed method. 27 (14 girls and 13 boys) grade twelve students in one higher secondary school participated in the study. The students were selected through non-probability convenient sampling techniques. The study revealed that the intervention program: and simulation games make concepts, ideas, and hypotheses easier to understand. The students have a positive opinion of simulation games used in teaching-learning. Simulation games make teaching-learning interesting, enjoyable, and fun. Through simulation games, students can score high marks on the class test. Students were engaged in self-assessment, self-awareness, self-monitoring, and reflective processes. However, the study revealed that simulation games are time-consuming and teachers need more time and effort for preparation and implementation. Simulation games are not always effective in teaching all micro and macroeconomics concepts.
State Differences in Tipping Attitudes and Behavior: Attributable to State Differences in Tipping Motivations?

Consumers around the world give away billions of dollars annually in the form of voluntary payments (aka, tips) to service workers who have served them. This widespread and important economic activity varies across geographic areas within nations, but that geographic variability has been under-studied. This paper seeks to answer the question: “Are state differences in tipping attitudes and behavior attributable to state differences in motivations for tipping? ” To that end, new measures of average tipping attitudes and motives in each of the states of the United States are developed, and their relationships with state tipping behaviors, as well as other theoretically relevant state-level measures, are tested. Results suggest meaningful and reliable state differences in attitudes toward and motivations for tipping, and that the latter differences underlie some, but not all, state differences in tipping behavior.