Miracle-dz/UniFAR-FTUs huggingface dataset:
A Generic Framework for Modeling and Simulation of Cloud Computing Services

Cloud Computing is a paradigm in which tasks are assigned to a combination of computing resources, software and services accessed over a network following the pay-as–you-go financial model. It has been also described as on-demand computing. With the continuous increases of cloud service providers, it becomes crucial to develop a simulation tool to reflect the properties of such complex environment to help clients selecting the appropriate providers. Available Cloudbased tools are designed for cloud architectures and resources scheduling, not the problem of provider selection. Even the Grid-based tools who share many features with the Cloud cannot cope with such problem due to the novel characteristics and services of the Cloud. This paper provides a new simulation tool that reflects the nature of clouds embedding all its aspects, as well as its QoS parameters. Such tool is designed to simulate any framework or solution for service provider selection problem. The proposed simulation tool is validated by running a framework developed for service provider selection problem based on QoS and utility functions. The paper also reviews various mathematical approaches that have been used to model cloud services, where most of them are formulations of cloud services that aim to optimize its quality of service, performance or energy efficiency under given constraints.
Odd-time magnetic correlations and chiral spin nematics.

The magnetic analog of odd-time superconducting order is introduced. It is shown that the classification of possible odd-time magnetic states admits the existence of a novel state - the chiral spin nematic - which is characterized by an odd-in-time spin-spin correlation function.The known example of the chiral spin liquid appears naturally in this approach. The equal-time correlation function of these odd-in-time states involves non-trivial three spin correlations.
LINC01638 silencing inhibits cancer cell proliferation in colorectal adenocarcinoma through interaction with RUNX2

lncRNA LINC01638 has been revealed to play an oncogenic role in triple negative breast cancer. The present study was carried out to investigate the involvement of LINC01638 in colorectal adenocarcinoma. In the present study it was observed that LINC01638 in plasma was upregulated in colorectal adenocarcinoma patients compared to healthy controls. Plasma levels of LINC01638 were affected by tumor size but not by distant metastasis. Plasma levels of Runt-related transcription factor 2 (RUNX2) were also higher in colorectal adenocarcinoma patients than in healthy controls, and were positively correlated with plasma levels of LINC01638 in colorectal adenocarcinoma patients but not in healthy controls. ROC curve analysis revealed that upregulation of LINC01638 distinguished colorectal adenocarcinoma at stage I and II from healthy controls. LINC01638 shRNA knockdown led to RUNX2 downregulation, while RUNX2 overexpression exhibited no significant effects on LINC01638. LINC01638 shRNA knockdown inhibited and RUNX2 overexpression promoted the proliferation of colorectal adenocarcinoma cells. RUNX2 overexpression attenuated the effects of LINC01638 shRNA knockdown on cancer cell proliferation. Therefore, lncRNA LINC01638 silencing may inhibit cancer cell proliferation in colorectal adenocarcinoma through its interaction with RUNX2.
(R,S)-2′-Amino-6′-methyl-2,5′,5′-trioxo-6′H-spiro[indoline-3,4′-pyrano[3,2-c][2,1]benzothiazine]-3′-carbonitrile dimethylformamide monosolvate

The title solvate, C20H14N4O4S·C3H7NO, comprises a stereogenic centre but the centrosymmetric space group causes the presence of the racemate in the crystal. The spiro-joined fragments are almost orthogonal, with a dihedral angle of 86.8 (2)° between the mean planes of the pyrane ring and the dihydroindolone ring system. The atoms of the indolinone bicycle are coplanar, with an r.m.s. deviation of 0.005 Å. In the crystal, pairs of N—H⋯O hydrogen bonds link the molecules into centrosymmetric dimers which are linked to the dimethylformamide solvent molecules by further N—H⋯O hydrogen bonds. N—H⋯N hydrogen bonds link neighbouring dimers into [010] chains.
Reconciling Antimicrobial Susceptibility Testing and Clinical Response in Antimicrobial Treatment of Chronic Cystic Fibrosis Lung Infections.

Median cystic fibrosis (CF) survival has increased dramatically over time due to several factors, including greater availability and use of antimicrobial therapies. During the progression of CF lung disease, however, the emergence of multi-drug antimicrobial resistance can limit treatment effectiveness, threatening patient longevity. Current planktonic-based antimicrobial susceptibility testing (AST) lacks the ability to predict clinical response to antimicrobial treatment of chronic CF lung infections. There are numerous reasons for these limitations including bacterial phenotypic and genotypic diversity, polymicrobial interactions and impaired antibiotic efficacy within the CF lung environment. The parallels to other chronic diseases such as non-CF bronchiectasis are discussed as well as research priorities for moving forward.
Recursive Approximability of Real Numbers

A real number is recursively approximable if there is a computable sequence of rational numbers converging to it. If some extra condition to the convergence is added, then the limit real number might have more eectivity. In this note we summarize some recent attempts to classify the recursively approximable real numbers by the convergence rates of the corresponding computable sequences of rational numbers and arithmetical reals. Mathematics Subject Classification: 03F60, 26E40, 03D80.
Image-Based Gating of Intravascular Ultrasound Sequences Using the Phase Information of Dual-Tree Complex Wavelet Transform Coefficients

Intravascular ultrasound (IVUS) is a widely used interventional imaging technique for the assessment of atherosclerosis plaque. Due to pulsatile heart motions, transverse and longitudinal motions are observed during in vivo pullbacks of IVUS sequences. These motion artifacts can mislead the volume-based data retrieved from IVUS studies and hinder the visualization of the vessel condition. To overcome this problem, a new fully automatic image-based gating algorithm was proposed in the current study. We utilized the phase information of the dual-tree complex wavelet transform (DT-CWT) coefficients to detect the motion of edge-like structures. For each IVUS sequence, first, six motion signals were detected by analyzing the phase of DT-CWT coefficients in six different directions. Then, the three best motion signals were selected by analyzing the frequency properties of each signal. Subsequently, these extracted signals were filtered using a modified Butterworth band-pass filter and the gated sequence was formed by using a combination of them. The proposed method was compared to four state-of-the-art methods and its frequency spectrum had more accurate characteristics in the cardiac frequency. In addition, the gated sequence extracted by the proposed method had the highest similarity to the extracted gated sequence by the physician.
MicroRNA-93 regulates angiogenesis in peripheral arterial disease by targeting CDKN1A

MicroRNAs (miRNAs) are considered to be critical mediators of gene expression with respect to tumor progression, although their role in ischemia-induced angiogenesis is poorly characterized, including in peripheral arterial disease (PAD). Furthermore, the underlying mechanism of action of specific miRNAs in PAD remains unknown. Reverse transcription-quantitative polymerase chain reaction analysis revealed that microRNA-93 (miR-93) was significantly upregulated in patients with PAD and in the EA.hy926 endothelial cells in response to hypoxia. Additionally, miRNA (miR)-93 promoted angiogenesis by enhancing proliferation, migration and tube formation. Cyclin dependent kinase inhibitor 1A (CDKN1A), verified as a potential target gene of miR-93, was inhibited by overexpressed miR-93 at the protein and mRNA expression levels. Furthermore, a hind-limb ischemia model served to evaluate the role of miR-93 in angiogenesis in vivo, and the results demonstrated that miR-93 overexpression enhanced capillary density and perfusion recovery from hind-limb ischemia. Taken together, miR-93 was indicated to be a promising target for pharmacological regulation to promote angiogenesis, and the miR-93/CDKN1A pathway may function as a novel therapeutic approach in PAD.
Do you observe what I perceive? The relationship between two perspectives on the ability of people with cognitive impairments to use everyday technology

Abstract Objectives: Everyday technologies (ETs) can be challenging to use, particularly for older adults with cognitive impairments. This study evaluated the relationship between the self-perceived ability to use ET and observable performance of self-chosen and familiar, but challenging ETs in people with mild cognitive impairment (MCI) or dementia. Method: A self-perceived report, the Everyday Technology Use Questionnaire (S-ETUQ), and a structured observational tool, the Management of Everyday Technology Assessment (META), assessing the perceived and observed ability to use ET, were used in 41 people with MCI and 38 people with dementia. Correlations were investigated with non-parametric statistical tests. Results: In the dementia group, self-perceived report and observational scores correlated on a significant medium level (Rs=0.44, p = 0.006). In the MCI group, no significant correlation was found. Conclusion: The findings of this study suggest the ability of older adults with cognitive impairments to use ETs can be depicted with self-perceived reports as well as with observations. However, the combination of both approaches is recommended to get a comprehensive picture. While the S-ETUQ provides a broad picture of the use, presence and relevance of technologies in an individual’s life, the META describes a specific human-technology interaction in detail. Furthermore, the results suggest people with early dementia retain the ability and insight to accurately reflect on their own ability to use ET, emphasizing the need to include their experiences in research and clinical work.
Lipid formation by aqueous Fischer-Tropsch-type synthesis over a temperature range of 100 to 400 degrees C.

The formation of lipid compounds during an aqueous Fischer-Tropsch-type reaction was studied with solutions of oxalic acid as the carbon and hydrogen source. The reactions were conducted in stainless steel vessels by heating the oxalic acid solution at discrete temperatures from 100 to 400 degrees C, at intervals of 50 degrees C for two days each. The maximum lipid yield, especially for oxygenated compounds, is in the window of 150-250 degrees C. At a temperature of 100 degrees C only a trace amount of lipids was detected. At temperatures above 150 degrees C the lipid components ranged from C12 to > C33 and included n-alkanols, n-alkanoic acids, n-alkyl formates, n-alkanals, n-alkanones, n-alkanes, and n-alkenes, all with essentially no carbon number preference. The n-alkanes increased in concentration over the oxygenated compounds at temperatures of 200 degrees C and above, with a slight reduction in their carbon number ranges due to cracking. It was also noted that the n-alkanoic acids increased while n-alkanols decreased with increasing temperature above 200 degrees C. At temperatures above 300 degrees C synthesis competes with cracking and reforming reactions. At 400 degrees C significant cracking was observed and polynuclear aromatic hydrocarbons and their alkylated homologs were detected. The results of this work suggest that the formation of lipid compounds by aqueous FTT reactions proceeds by insertion of a CO group at the terminal end of a carboxylic acid functionality to form n-oxoalkanoic acids, followed by reduction to n-alkanoic acids, to n-alkanals, then to n-alkanols. The n-alkenes are intermediate homologs for n-alkan-2-ones and n-alkanes. This proposed mechanism for aqueous FTT synthesis differs from the surface-catalyzed stepwise FT process (i.e., gaseous) of polymerization of methylene reported in the literature.
Mechano- or Acid Stimulation, Two Interactive Modes of Activation of the TREK-1 Potassium Channel*

TREK-1 is a member of the novel structural class of K+ channels with four transmembrane segments and two pore domains in tandem (1, 2). TREK-1 is opened by membrane stretch and arachidonic acid. It is also an important target for volatile anesthetics (2, 3). Here we show that internal acidification opens TREK-1. Indeed, lowering pH i shifts the pressure-activation relationship toward positive values and leads to channel opening at atmospheric pressure. The pH i -sensitive region in the carboxyl terminus of TREK-1 is the same that is critically involved in mechano-gating as well as arachidonic acid activation. A convergence, which is dependent on the carboxyl terminus, occurs between mechanical, fatty acids and acidic stimuli. Intracellular acidosis, which occurs during brain and heart ischemia, will induce TREK-1 opening with subsequent K+ efflux and hyperpolarization.
Motivation and melancholy: a darwinian perspective.

Table 1: Situations that Arise in Goal Pursuit, and Corresponding EmotionsAn enormous body of work documents the relationship between goal pursuit and affect (Gollwitzer & Moskowitz, 1996). Except for a hiatus during the heyday of behaviorism, goals and their effects and associated affects have been a central concern in social psychology. Behavioral strategies are influenced by the content of goals, their conflicts with other goals, and how they are framed. Several closely related varieties of goals have been defined, including current concerns (Klinger, 1975), personal strivings (Emmons & King, 1988), personal projects (Little, Lecci, & Watkinson, 1992), life tasks (Cantor, 1994) For a summary, see Emmons (1999). With few exceptions (Buss, 1995; Klinger, 1998), however, this enterprise has proceeded independently from developments in evolutionary biology and behavioral ecology.
Factor Analytic Study of Irrational Beliefs

This study investigated the validity of the Rational-Emotive Therapy construct of irrational beliefs and provided discriminant validity for a test of irrational beliefs, the Idea Inventory. 216 male psychiatric inpatients from a large medical center were administered a battery of psychological measures. These included the Idea Inventory, the MMPI, the Beck Depression Inventory, the Hooper Visual Organization Test, and the Shipley Institute of Living Scale. The Idea Inventory is a 33-item scale assessing the 11 irrational beliefs of Ellis's RET schema. Correlations showed that there is adequate internal consistency among the 11 subscales of the Idea Inventory and that there were 73 of 110 significant coefficients between this scale and the MMPI. Only a small amount of common variance, however, is accounted for. Most importantly, a factor analysis using all of the scales yielded five factors. The first factor included the scales of the Idea Inventory exclusively, with the MMPI and cognitive scales loading on other factors. Discussion centered on the validity of the Idea Inventory and on the independence of irrational beliefs and psychopathology.
G2 chromatid aberrations: Kinetics and possible mechanisms

Chromatid breaks and exchanges are induced by radiation in G2 mammalian cells. Breaks are at a maximum number at about 30 min after irradiation and decrease apparently exponentially with time between irradiation and sampling. Few breaks are observed immediately following exposure, probably as a result of selection of mitotic cells where chromosomes are condensed and there is consequently a lack of time for expression of damage. The change in frequency of breaks with time, from 30 min after radiation exposure and onwards, can be interpreted in two possible ways: either in terms of a repair process or in terms of a change in radiosensitivity through G2. However, our results with an inhibitor of repair of DNA double‐strand breaks (ara A) and with “transient hypothermia” which extends the G2 phase, argue for an interpretation based on rejoining of chromatid breaks, possibly reflecting the repair of a subclass of dsb. Data from experiments with irradiated and restriction endonuclease treated radiosensitive mutant rodent lines indicate that enhanced levels of conversion of dsb into chromosomal aberrations may be largely independent of repair rates of bulk dsb. In CHO cells and in human lymphocytes exchanges initially increase rapidly with time and then remain at a constant frequency, supporting the notion of a uniform chromosomal radiosensitivity throughout most of G2 and providing further evidence that the mechanism for mis‐joining broken chromatids (leading to exchanges) is different from that for rejoining of chromatid breaks. Ratios of breaks to exchanges were found to vary in different cell lines and at different times during treatment with inhibitors or at altered temperatures, possibly (in different cell lines) indicating different levels of enzymes involved in misjoining, but suggesting that the mechanisms of chromosomal rejoining and misjoining are independent, at least to some degree. © 1993 Wiley‐Liss, Inc.
Interleaving Concealment Method for CELP-Based Coders in Packet Networks

paper presents an interleaving concealment method to improve speech quality deterioration caused by packet losses for CELP based coders. We applied the proposed scheme to the standard ITU-T G729 standard speech coder to evaluate the proposed method. The perceptual evaluation of speech quality (PESQ) and enhanced modified bark spectral distortion (EMBSD) tests under various packet loss conditions confirm that the proposed algorithm is superior to the concealment algorithm embedded in the G729. The spectral distortion measure is also used as an objective distortion measure; the obtained results prove that the interleaving method is better at the expense of extra delay.
The presence of BRAF point mutation in adult papillary thyroid carcinomas from atomic bomb survivors correlates with radiation dose

In papillary thyroid carcinogenesis, the constitutively activated mitogen‐activated protein (MAP) kinase signaling pathway caused by a genetic alteration such as RET/PTC rearrangement or mutation of RAS and BRAF genes, is thought to be a major early event. Among these, the recently identified BRAFV600E mutation has been found at high frequency in adult patients with papillary thyroid carcinoma (PTC). However, the association between this mutation and radiation exposure in adult PTC is still unknown. In this study, we examined the BRAFV600E mutation in 64 PTCs among adult atomic bomb survivors in Hiroshima, Japan, comprising 17 nonexposed (0 mGy) and 47 exposed patients who developed the carcinoma after the bombing, and assessed the association of BRAFV600E mutation with clinico‐pathological and epidemiological variables. The median radiation dose in PTCs with the BRAFV600E mutation was significantly lower than that without the mutation (18.5 vs.156.9 mGy, Wilcoxon rank‐sum test, P = 0.022). A significant difference was found in the median latency period (years elapsed from atomic bombing to diagnosis) between exposed patients with and without BRAFV600E mutation (29 vs. 21 yr, Wilcoxon rank‐sum test, P = 0.014). These findings were further confirmed by logistic regression analysis with BRAFV600E mutation status as a dependent variable and taking into account possible interactions between the variables. We found that the log‐transformed radiation dose and latency period were independently associated with the BRAFV600E mutation (P = 0.039 and P = 0.010, respectively). These results suggest that involvement of BRAF mutation in thyroid carcinogenesis in exposed people may differ from that in the nonexposed people. © 2006 Wiley‐Liss, Inc.
Differential regulation of Toll-like receptor and CD14 pathways by retinoids and corticosteroids in human sebocytes.

active retinoid by slightly upregulating mRNA levels of TLR2, TLR4 and CD14, while 13- cis -RA and all- transRA were practically inactive. Retinoids did not affect mRNA levels of IL-1 � , IL-1 � and IL-8 mRNA and their release. However, IL-6 mRNA levels and release were significantly reduced under treatment with 13- cis -RA and all- trans -RA being more potent than retinol, indicating a selective, TLR-independent, anti-inflammatory effect of retinoids on SZ95 sebocytes. Hydrocortisone slightly upregulated TLR2 mRNA levels but markedly reduced TLR4 and CD14 mRNA levels. Furthermore, hydrocortisol induced an overall reduction of cytokine/chemokine expression, a finding that undersigns its global antiinflammatory activity. We provide evidence that the pharmacological regulation of TLR and CD14 expression may provide a novel mechanism in the treatment of inflammatory acne lesions. The combination of 13-cis- retinoic acid (RA) and corticosteroids has been shown to be markedly effective in severe inflammatory acne, such as acne fulminans. We have currently shown human epithelial cells to induce and modulate inflammatory signals by Toll-like receptors (TLRs) and CD14 in acne. By this pathway the innate immunity is able to recognize microbial components and to induce cytokine/chemokine synthesis. We examined the effects of retinoids, hydrocortisone and the microbial components lipopolysaccharide and lipoteichonic acid on TLR2, TLR4 and CD14 expression as well as on cytokine/chemokine expression in human SZ95 sebocytes. Human SZ95 sebocytes were found to constitutively express TLR2, TLR4, CD14, interleukin (IL)-1 � , IL-1 � , IL-6 and IL-8 that was augmented by exposure to components of Gram-negative (lipopolysaccharide) and Gram-positive (lipoteichonic acid) bacteria. Retinol was the most
A Probabilistic Quantifier Fuzzification Mechanism: The Model and Its Evaluation for Information Retrieval

In this paper, we propose a new quantifier fuzzification mechanism which is deeply rooted in the theory of probability. This quantifier fuzzification mechanism skips the nested assumption, which is inherent to other probabilistic quantification methods. The new quantification approach complies with the properties required for determiner fuzzification schemes (DFS) with finite sets and, hence, its good behavior is assured. Moreover, this new approach is suitable for some application domains. In particular, the use of fuzzy quantifiers for implementing query quantified statements for information retrieval exemplifies the adequacy of the new proposal. The new quantifier fuzzification mechanism has been efficiently implemented and empirically tested for a retrieval task. This practical evaluation followed the standard methodology in the field of information retrieval and was conducted against a popular benchmark consisting of a large collection of documents. The retrieval performance evaluation made evident that: 1) the new method can work in realistic scenarios, and 2) it can overcome recent proposals for applying fuzzy quantifiers in information retrieval