Miracle-dz/UniFAR-FTUs huggingface dataset:
MAPK15 upregulation promotes cell proliferation and prevents DNA damage in male germ cell tumors

Germ cell tumors (GCT) are the most common malignancies in males between 15 and 35 years of age. Despite the high cure rate, achieved through chemotherapy and/or surgery, the molecular basis of GCT etiology is still largely obscure. Here, we show a positive correlation between MAPK15 (ERK8; ERK7) expression and specific GCT subtypes, with the highest levels found in the aggressive embryonal carcinomas (EC). Indeed, in corresponding cellular models for EC, MAPK15 enhanced tumorigenicity in vivo and promoted cell proliferation in vitro, supporting a role for this kinase in human GCT. At molecular level, we demonstrated that endogenous MAPK15 is necessary to sustain cell cycle progression of EC cells, by limiting p53 activation and preventing the triggering of p53-dependent mechanisms resulting in cell cycle arrest. To understand MAPK15-dependent mechanisms impinging on p53 activation, we demonstrate that this kinase efficiently protects cells from DNA damage. Moreover, we show that the ability of MAPK15 to control the autophagic process is necessary for basal management of DNA damage and for tumor formation controlled by the kinase. In conclusion, our findings suggest that MAPK15 overexpression may contribute to the malignant transformation of germ cells by controlling a “stress support” autophagic pathway, able to prevent DNA damage and the consequent activation of the p53 tumor suppressor. Moreover, in light of these results, MAPK15-specific inhibitors might represent new tools to enhance the therapeutic index of cytotoxic therapy in GCT treatment, and to increase the sensitivity to DNA-damaging drugs in other chemotherapy-resistant human tumors.
The need for systems change: reflections on knowledge translation and organizational change.

BACKGROUND Despite over 40 years' work on general systems theory, informed by critical social science, there is a mismatch between the theories used to explain and influence clinical practice in nursing and the way in which transferring new knowledge into practice is articulated. DATA SOURCES The analysis and emerging propositions were based on a critique of seminal texts published in English up to 2008 covering critical social science, action science, diffusion of innovations, practice development and the management of innovations. DISCUSSION There is an implicit adherence to the world view that healthcare systems operate like machines, and much of the science generated around knowledge translation research tends to be logico-deductive. This is in direct contrast to the prevailing arguments of general systems theorists, who view the system more as an organism. Five propositions are posited: knowledge translation is a necessary but not sufficient mechanism to transform systems; the 'system-as-machine' metaphor is profoundly unhelpful to knowledge translation; the healthcare system is best viewed as a complex entity; successful innovation is a function of the level of local autonomy experienced by individuals, teams and the unit involved; innovation is most effective when it involves key stakeholders. CONCLUSION The purposeful integration of systems theory with knowledge translation theories and models may enable the application of research and new knowledge to practice to be speeded up.
Bromide Space Studies in Infants of Low Birth Weight

Extract: The present study reports measurements of the corrected bromide space (CBS) in 74 neonates delivered vaginally and studied within 24 h of birth. The results in 37 normally grown (NG) infants ranging in birth weight from 960 to 3,450 g with gestational intervals of 27–43 weeks are contrasted with findings in 37 intrauterine growth-related infants (IGR) ranging from 1,000 to 2,460 g in birth weight with gestational intervals of 35–44 weeks.Although a direct relation exists between CBS (liters) and a varicty of variables of fetal maturity in both NG and IGR infants, the CBS in both groups would appear best related to birth weight. The corrected bromide space of IGR was virtually identical with that of their weith peers, there being no significant difference in the regression for CBS versus birth weight in the two groups. Log-log plot of this relation yields a correlation coefficient (r) of 0.98, and may be expressed as:log CBS (liters) = 0.92 × log wt (kg) - 0.371Closer inspection of this relation revealed that an unequal distribution, with preponderance of values below the regression line at higher birth weights, was apparent. That ‘tail off’ suggested a curvilinear relation of CBS with increasing birth weitht, and was even more apparent when the CBS data were expressed as percentage of bedy weight (m1/kg). The mean CBS/kg in NG prematures (424±SE 7.5 m1/kg) was clearly higher (p <0.001) than in mature study infants (376±SE 8.4 m1/kg). Likewise, the average CBS/kg in the mature IGR (419±SE 11.3 m1/kg) was significantly higher (p <0.025) than the mean for the NG infants (376±SE 8.4 m1/kg). Conparison of data from NG and IGR infants revealed that 3 of 10 premature infants and 10 of 27 mature IGR infants have a CBS/kg more than 2 SD above the mean in NG infants; a CBS in excess of 476 m1/kg was observed in 11 study infants, all but 1 of whom were IGR.Speculation: Characteristically, expansion of body water compartments accompanies postnatal malnutrition. In intrauterine growth retardation, similar changes in body fluid compartments suggest an etiologic role for ‘fetal malnutrition’ in the disorder.
Análise da influência dos diferentes tempos de polimerização por luz incandescente sobre a resistência ao desgaste abrasivo de resinas compostas

In the current market an increasing quality is demanded to manufacture products. At the odontologic market the composed resins are becoming more and more used to replace old materials, like amalgamates in the aesthetic and functional restorations, since they present a better appearance and easier manuscript. The chemical composition of these materials varies and the results of the chemical reactions of polymerization processes are quite unknown. The aim of this work was to measure the resistance of the abrasive wear of six composed resins sold in Brazilian market when displayed to polymerization periods of 10, 20 and 40 seconds. The grinding disc method appropriated for odontology was used to make this process possible. For this a bank of assays in which a porcelain covered dynamic disc consumes a static disc recovered by the polymerized resin is used to demonstrate the method in a pre-established time. The abrasive wear was determined by the calculation of the aggressiveness (capacity of a material to consume another). This aggressiveness is determined by an initial graph of displacement for time, through the computational method (LabView program). After they have passed through a linear regression the results give as a possibility the angular coefficient, considered a parameter at the calculation of aggressiveness. Higher values of aggressiveness which means a higher aggression suffered by the resin disc indicate worse resistance to the abrasive consuming of this resin in relation to porcelain. The results showed a variable comportment for each material ahead the different polymerization time, which prove the importance in create a practical and fast analyses method to test new materials before their use.
High-resolution quantitative ultrasound imaging for soft tissue classification

Mouse models have been widely used in cardiovascular research when investigating the progression or treatment of various diseases. It is always challenging to find non-invasive tools for early detection of diseases. This led us to the development of small animal models for diagnostic imaging techniques, such as high-frequency quantitative ultrasound imaging. This work describes the development of an ultrasound tissue classification technique that could be used to quantitatively assess atherosclerotic plaques in mouse heart. Signal and image processing of radiofrequency ultrasound data have been performed in time, frequency, and wavelet domains to quantitatively assess the severity of atherosclerosis in an APOE-KO mouse model fed with high fat diet. Multiple in vitro experiments were conducted, and ultrasound images of high contrast-resolution were obtained using parameters from various domains. For example, images reconstructed using the time variance (Tσ2), and frequency skewness (PDskew) parameters showed high-contrast resolutions of approximately 17.95±2.98 dB, and 9.67±0.24 dB (n=4) between normal tissue and atherosclerotic lesions. The technique is integrated with a custom-designed high-frequency ultrasound imaging system and is able to provide parametric images of high contrast and special resolution down to 24 microns.
The Notch Ligand JAG1 Is Required for Sensory Progenitor Development in the Mammalian Inner Ear

In mammals, six separate sensory regions in the inner ear are essential for hearing and balance function. Each sensory region is made up of hair cells, which are the sensory cells, and their associated supporting cells, both arising from a common progenitor. Little is known about the molecular mechanisms that govern the development of these sensory organs. Notch signaling plays a pivotal role in the differentiation of hair cells and supporting cells by mediating lateral inhibition via the ligands Delta-like 1 and Jagged (JAG) 2. However, another Notch ligand, JAG1, is expressed early in the sensory patches prior to cell differentiation, indicating that there may be an earlier role for Notch signaling in sensory development in the ear. Here, using conditional gene targeting, we show that the Jag1 gene is required for the normal development of all six sensory organs within the inner ear. Cristae are completely lacking in Jag1-conditional knockout (cko) mutant inner ears, whereas the cochlea and utricle show partial sensory development. The saccular macula is present but malformed. Using SOX2 and p27kip1 as molecular markers of the prosensory domain, we show that JAG1 is initially expressed in all the prosensory regions of the ear, but becomes down-regulated in the nascent organ of Corti by embryonic day 14.5, when the cells exit the cell cycle and differentiate. We also show that both SOX2 and p27kip1 are down-regulated in Jag1-cko inner ears. Taken together, these data demonstrate that JAG1 is expressed early in the prosensory domains of both the cochlear and vestibular regions, and is required to maintain the normal expression levels of both SOX2 and p27kip1. These data demonstrate that JAG1-mediated Notch signaling is essential during early development for establishing the prosensory regions of the inner ear.
Some Sufficient Stability Conditions on T-S Fuzzy Systems with Time-Delay

Some sufficient stability conditions on T-S fuzzy systems with time-delay are given in this paper. First, the T-S fuzzy models with time-delay are presented and the sufficient stability conditions are derived by using the second Lyapunov functional approach. Then a stabilization approach for nonlinear retarded systems through fuzzy state feedback controller is proposed. It shows that the analysis results provide an efficient technique for the design of fuzzy controllers. Sufficient conditions for the existence of fuzzy state feedback gain of the time-delay systems are derived through the numerical solution of a set of coupled linear matrix inequalities.
Effect of Gas Metal Arc Welding Parameters on Mechanical Properties for Carbon Steel ASTM A285 Grade A

The research was study the effect of gas metal arc welding process parameters on mechanical property. The specimen was carbon steel ASTM A285 grade A which thickness of 6 mm. The experiments with full factorial design. The factors used in this study are shielding gas and voltage. The welded specimens were tested by tensile strength testing and hardness testing according to ASME boiler and pressure vessel code section IX 2007. The result showed that both of shielding gas and voltage had interaction on tensile strength and hardness at 95% confidential (P value < 0.05). Factors affecting the tensile strength are the most carbon dioxide and 27 voltage were tensile strength 213.43 MPa. And hardness maximum of 170.60 HV can be used carbon dioxide and 24 voltage. This research can be used as data in the following appropriate parameters to gas metal arc welding process.
Microscopic Understanding of the Anisotropic Conductivity of PEDOT:PSS Thin Films

The anisotropic conductivity of spin-coated poly(3,4- ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) thin films by temperature-dependent conductivity measurements, has been analyzed. A detailed 3D morphological model was derived from topographic scanning tunneling microscopy (STM) and cross-sectional atomic force microscopy (AFM) images, which correlated the anisotropy, both in conductivity magnitude and in the conduction mechanism. Spin coated films of PEDOT:PSS formed a reasonably homogenous material in terms of electrical conductivity. It was observed that the vertical conductivity that is perpendicular to the substrate, can be up to three orders of magnitude lower than the lateral conductivity in the plane of the film. The macroscopic in-plane conductivity was found to be completely isotropic, and the ordering was found to be confined to randomly oriented micrometer-size domains.
The Impact of Species Concept on Biodiversity Studies

Species are defined using a variety of different operational techniques. While discussion of the various methodologies has previously been restricted mostly to taxonomists, the demarcation of species is also crucial for conservation biology. Unfortunately, different methods of diagnosing species can arrive at different entities. Most prominently, it is widely thought that use of a phylogenetic species concept may lead to recognition of a far greater number of much less inclusive units. As a result, studies of the same group of organisms can produce not only different species identities but also different species range and number of individuals. To assess the impact of different definitions on conservation issues, we collected instances from the literature where a group of organisms was categorized both under phylogenetic and nonphylogenetic concepts. Our results show a marked difference, with surveys based on a phylogenetic species concept showing more species (48%) and an associated decrease in population size and range. We discuss the serious consequences of this trend for conservation, including an apparent change in the number of endangered species, potential political fallout, and the difficulty of deciding what should be conserved.
Aggregate Structure Evolution for Size-Dependent Aggregation by Means of Monte Carlo Simulations

Aggregation during crystallization and precipitation processes often leads to complex-shaped particle aggregates. As an alternative to low-dimensional deterministic population balance models, where assumptions on the particle shape must be made, stochastic or so-called Monte Carlo methods can be employed. In previous work a hierarchical characterization of aggregates has been proposed (Briesen, AIChE J., 52, 2436-2446, 2006), which allows the use of different levels of detail for modelling the different rate processes as primary particle growth or particle aggregation. With that hierarchical characterization, the detailed geometry of aggregates becomes accessible for rate process modelling and product characterization. Here, this framework is extended to investigate size-dependent collision rates and aggregation ef ficiencies. The results show that the aggregate structures can be modelled by the interplay of shear rate and the growth rate at the particle necks in a mechanistic way. Future work will address the comparison with experimental data and alternative model formu-
Effect of polyurethane/nanosilica composite coating on thermomechanical properties of polyethylene film

Abstract Polyurethane (PU)/nanosilica composite was fabricated and then coated on polyethylene (PE) film using a rod Mayer technique. The silica nanoparticles used have an average particle size of 16 nm, and their weight fractions varied from 0 to 14%. Two different thicknesses of PU/nanosilica coating layer were fabricated, which were 4 and 8 μm. The morphology and thermal mechanical properties of the nanocomposite coated PE film were characterised using scanning electron microscope, dynamic mechanical analyser, thermogravimetric analyser as well as tensile tests. The results showed that a thin layer coating of PU/nanosilica composite has a slightly reduced tensile strength of the PE substrate. However, the nanocomposite coating of up to 8 μm reduced the elongation of PE substrate significantly. The PU/nanosilica composite coating layer increased the tensile modulus and stiffness of the PE substrate. There was no influence of PU/nanosilica composite coating on the thermal degradation rate of the PE film.
Effective Efficiency of Solar Air Heaters of Different Types of Roughness Geometries over Absorber Plate

Artificial roughness has been found to enhance the rate of heat transfer in solar air heater ducts. However, improvement in heat transfer enhancement is invariably accompanied by increased pumping power. Several investigators have investigated the effect of different types of roughness on solar air heaters on the basis of heat transfer and friction factor. This paper presents a comparison of effective efficiency of solar air heaters of various types of roughness geometries over the absorber plate. These geometries have been used by various investigators in order to increase the heat transfer and friction factor in solar air heaters. Based upon correlations developed by various investigators, effective efficiency is also compared for a set of roughness geometries within the investigated range of operating parameters. doi: 10.14456/WJST.2014. 92
Acute care patients discuss the patient role in patient safety

Background: Patient safety has been a highly researched topic in health care since the year 2000. One strategy for improving patient safety has been to encourage patients to take an active role in their safety during their health care experiences. However, little research has shed light on how patients view their roles. Purpose: This study attempted to address this deficit by inductively exploring the results of a qualitative study in which patients reported their ideas about what they believe their roles should be. Methodology: Patients with an overnight stay in the previous 90 days at one of three hospitals were surveyed using a mailing methodology. Of 1,040 respondents, 491 provided an open-ended response regarding what they believe the patient role should be. Findings: Qualitative analysis found several prominent themes. The largest proportion of responses (23%) suggested that patients should follow instructions given by care providers. Other prominent themes were that patients should ask questions and become informed about their conditions and treatments, and many implied that they should expect competent care. Our results suggest that patients believe they should be able to trust that they are being provided competent care, as opposed to assuming a leadership role in their safety. Practice Implications: Our results suggest that engaging patients in safety efforts may be complex, requiring a variety of strategies. Managers must provide environments conducive to staff and patient interactions to support patients in this effort. Different types of patients may require different engagement strategies.
Hybrid Optimize Strategy based QoS Route Algorithm for Mobile Ad hoc Networks

It is very difficult to find feasible QoS (Quality of service) routes in the mobile ad hoc networks (MANETs), because of the nature constrains of it, such as dynamic network topology, wireless communication link and limited process capability of nodes. In order to reduce average cost in flooding path discovery scheme of the traditional MANETs routing protocols and increase the probability of success in finding QoS feasible paths and we proposed a heuristic and distributed route discovery method named RLGAMAN that supports QoS requirement for MANETs in this study. This method integrates a distributed route discovery scheme with a reinforcement learning (RL) method that only utilizes the local information for the dynamic network environment; and the route expand scheme based on genetic algorithms (GA) method to find more new feasible paths and avoid the problem of local optimize. We investigate the performance of the RLGAMAN by simulation experiment bed in NS2. Compared with traditional method, the experiment results showed the network performance is improved obviously and RLGAMAN is efficient and effective.
Comparative evaluation of robotic software integration systems: A case study

One might expect that after nearly 50 years of research in robot manipulation and mobile robotics the architectural design of robot systems has converged to a small set of best practice solutions, very much like in the area of operating systems, where the world is dominated by less then a handful systems. Quite the opposite is the case. It is only a small overstatement to say that almost every lab has brewed its own solution for robot control architecture, middleware and software integration concepts. One reason for this situation is the fact that the complexity and variety of systems and applications has grown considerably since then leading to a diversity of approaches. Another reason is clearly the lack of any sound methodology to measures and compare architectural designs. This article tries to address the problem by proposing a comparison and evaluation methodology for robotics software systems. The methodology facilitates an assessment of software systems through experimentation and takes into account the possible operational profile and quality attribute requirements of the robotic application. The approach is validated through the evaluation of three software systems, i.e. GenoM, ORCA2 and GO. The results suggest possible applicability domains of each system and show the efficiency of the approach.
A utility-based two level market solution for optimal resource allocation in computational grid

The paper presents a market oriented resource allocation strategy for grid resource. The proposed model uses the utility functions for calculating the utility of a resource allocation. This allows the integration of different optimization objectives into allocation process. This paper is target to solve above issues by using utility-based optimization scheme. We decompose the optimization problem into two levels of subproblems so that the computational complexity is reduced. Two market levels converge to its optimal points; a globally optimal point is achieved. Total user benefit of the computational grid is maximized when the equilibrium prices are obtained through the service market level optimization and resource market level optimization. The economic model is the basis of an iterative algorithm that, given a finite set of requests, is used to perform optimal resource allocation. The experiments show that scheduling based on pricing directed resource allocation involves less overhead and leads to more efficient resource allocation than conventional round robin scheduling.
Methods and Model Evaluation for Probabilistic Load Flow Used in Electrical Engineering Education

The main focus of this paper is to presents comparative principal problems of bibliographies on the linearization of Load Flow equations, network outages and the interdependence among nodal power injections. These methods classified as simulation method, analytical method, or by a combination of both are used to obtain the mean and variance of Power Line Flow. Key-Words: Cumulative Distribution Function (CDF), Probabilistic Density Function (PDF), Deterministic Load Flow(DLF), Monte Carlo Simulations (MCS), Probabilistic Load Flow (PLF), Stochastic Load Flow (SLF).