Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of pharmacist counseling in preventing adverse drug events after hospitalization.

BACKGROUND Hospitalization and subsequent discharge home often involve discontinuity of care, multiple changes in medication regimens, and inadequate patient education, which can lead to adverse drug events (ADEs) and avoidable health care utilization. Our objectives were to identify drug-related problems during and after hospitalization and to determine the effect of patient counseling and follow-up by pharmacists on preventable ADEs. METHODS We conducted a randomized trial of 178 patients being discharged home from the general medicine service at a large teaching hospital. Patients in the intervention group received pharmacist counseling at discharge and a follow-up telephone call 3 to 5 days later. Interventions focused on clarifying medication regimens; reviewing indications, directions, and potential side effects of medications; screening for barriers to adherence and early side effects; and providing patient counseling and/or physician feedback when appropriate. The primary outcome was rate of preventable ADEs. RESULTS Pharmacists observed the following drug-related problems in the intervention group: unexplained discrepancies between patients' preadmission medication regimens and discharge medication orders in 49% of patients, unexplained discrepancies between discharge medication lists and postdischarge regimens in 29% of patients, and medication nonadherence in 23%. Comparing trial outcomes 30 days after discharge, preventable ADEs were detected in 11% of patients in the control group and 1% of patients in the intervention group (P = .01). No differences were found between groups in total ADEs or total health care utilization. CONCLUSIONS Pharmacist medication review, patient counseling, and telephone follow-up were associated with a lower rate of preventable ADEs 30 days after hospital discharge. Medication discrepancies before and after discharge were common targets of intervention.
Exploring the Capacity of Open, Linked Data Sources to Assess Adverse Drug Reaction Signals

In this work, we explore the capacity of open, linked data sources to assess adverse drug reaction (ADR) signals. Our study is based on a set of drugrelated Bio2RDF data sources and three reference datasets, containing both positive and negative ADR signals, which were used for benchmarking. We present the overall approach for this assessment and refer to some early findings based on the analysis performed so far.
Mining N-most interesting itemsets without support threshold by the COFI-tree

Data mining is the discovery of interesting and hidden patterns from a large amount of collected data. Applications can be found in many organisations with large databases, for many different purposes such as customer relationships, marketing, planning, scientific discovery, and other data analysis. In this paper, the problem of mining N-most interesting itemsets is addressed. We make use of the techniques of COFI-tree in order to tackle the problem. In our experiments, we find that our proposed algorithm based on COFI-tree performs faster than the previous approach BOMO based on the FP-tree.
Comprehensive Phylogenetic Diversity of [FeFe]-Hydrogenase Genes in Termite Gut Microbiota

Phylogenetic diversity of [FeFe]-hydrogenase (HydA) in termite guts was assessed by pyrosequencing PCR amplicons obtained using newly designed primers. Of 8,066 reads, 776 hydA phylotypes, defined with 97% nucleotide sequence identity, were recovered from the gut homogenates of three termite species, Hodotermopsis sjoestedti, Reticulitermes speratus, and Nasutitermes takasagoensis. The phylotype coverage was 92–98%, and the majority shared only low identity with database sequences. It was estimated that 194–745 hydA phylotypes existed in the gut of each termite species. Our results demonstrate that hydA gene diversity in the termite gut microbiota is much higher than previously estimated.
Ultra high definition HEVC DASH data set

Ultra High Definition video is entering a phase of deployment tests, with first UHD services being launched in late 2013. Most on-air broadcast UHD services will not start until 4K display market penetration is high enough, which will not happen until at least 2018. Therefore, most initial services will be offered via IPTV services or Over-The-Top delivery technologies. On the other hand, the new HEVC video compression standard, with a 50% gain over its predecessor AVC|H.264, is the natural industry choice for compressing UHD content; at the transport level, MPEG-DASH offers a complete set of tools for broadcast and broadband convergence, and is one of the first candidates for HEVC preferred transport layer. In this context, deployment tests of MPEG-DASH and UHD HEVC content are expected to be a very important topic in the next two years. In this paper, we present a Ultra High Definition HEVC DASH dataset ranging from HD to UHD in different bit rates. This data set may be used to simulate UHD DASH services, whether on-demand or live, using real-life professional quality content.
Effects of TiO2 Addition on the Electrochemical Performance of the Overlay Welded High-manganese Steel Cladding

Series of overlay flux-cored wires with different content of TiO 2 were fabricated, and different claddings of high-manganese steel are welded by flux cored arc welding (FCAW). The influences of TiO 2 addition on the electrochemical behaviour of the FCAW claddings over a high-manganese steel were studied. The results demonstrate that all the LPR values of the overlay welded claddings are higher than that of the base metal. However, the LPR values did not increase with the addition of TiO2. The EIS simulation results indicate that the addition of titanium dioxide improves the corrosion resistance of the high-manganese steel cladding, and the trends of the Rp values is highly consistent with the change of LRP value. At the same time, the grain refinement was achieved by the TiO 2 addition. In conclusion, the proper content of the titanium dioxide in high-manganese steel cladding contributes to its high LRP and Rp values, in this paper, the suitable content of the TiO 2 addition is 20g (0.2wt.%).
Calcium and magnesium concentrations in uterine fluid and blood serum during the estrous cycle in the bovine

To investigate uterine and serum Ca++ and Mg++ variations during the estrous cycle in the bovine, 66 genital tracts and blood samples were collected from Urmia abattoir, Urmia, Iran. The phase of the estrous cycle was determined by examination of the structures present on ovaries and uterine tonicity. Of the collected samples, 17 were pro-estrus, 12 estrus, 14 metestrus and 23 diestrus. The uterine fluid was collected by gentle scraping of the uterine mucosa with a curette. The mean ± SEM concentration of serum Ca++ in pro-estrus, estrus, metestrus and diestrus was 5.77 ± 0.69, 8.87 ± 1.83, 10.95 ± 1.52, 11.09 ± 1.08 mg dL-1, and the mean concentration of uterine fluid Ca++ was 4.40 ± 0.72, 3.15 ± 0.67, 5.89 ± 0.88, 8.63 ± 0.97 mg dL-1, respectively. The mean concentration of serum Mg++ in pro-estrus, estrus, metestrus and diestrus was 3.53 ± 0.30, 4.20 ± 0.52, 3.49 ± 0.38, 3.39 ± 0.29 mg dL-1, and mean concentration of uterine fluid Mg++ was 5.27 ± 0.42, 4.92 ± 0.60, 5.56 ± 0.30, 5.88 ± 0.36 mg dL-1, respectively. The serum and uterine fluid Ca++ in pro-estrus were significantly different from those of the metestrus and diestrus. In all stages of estrous cycle the mean concentration of serum Ca++ was higher than that in the uterine fluid. The difference between serum and uterine fluid Ca++ in estrus, metestrus and diestrus was significant. There was no significant difference between serum Mg++ content nor was it different from uterine fluid Mg++ content at any stages of estrous cycle. In all stages of estrous cycle the uterine fluid Mg++ was higher than that of the serum. These results suggest that during the estrous cycle in the cow, Ca++ is passively secreted in uterine fluids and is mostly dependent on blood serum Ca++ variations but Mg++ is secreted independently and does not follow variations in the serum concentrations.
Protein Kinase B/Akt Prevents Fatty Acid-induced Apoptosis in Pancreatic β-Cells (INS-1)*

Free fatty acids (FFA) have been reported to reduce pancreatic β-cell mitogenesis and to increase apoptosis. Here we show that the FFA, oleic acid, increased apoptosis 16-fold in the pancreatic β-cell line, INS-1, over a 18-h period as assessed by Hoechst 33342/propidium iodide staining and caspase-3 and -9 activation, with negligible necrosis. A parallel analysis of the phosphorylation activation of protein kinase B (PKB) showed this was reduced in the presence of FFA that correlated with the incidence of apoptosis. At stimulatory 15 mm glucose and/or in the added presence of insulin-like growth factor 1, FFA-induced β-cell apoptosis was lessened compared with that at a basal 5 mmglucose. However, most strikingly, adenoviral mediated expression of a constitutively active PKB, but not a “kinase-dead” PKB variant, essentially prevented FFA-induced β-cell apoptosis under all glucose/insulin-like growth factor 1 conditions. Further analysis of pro-apoptotic downstream targets of PKB, implicated a role for PKB-mediated phosphorylation inhibition of glycogen synthase kinase-3α/β and the forkhead transcription factor, FoxO1, in protection of FFA-induced β-cell apoptosis. In addition, down-regulation of the pro-apoptotic tumor suppresser protein, p53, via PKB-mediated phosphorylation of MDM2 might also play a role in partially protecting β-cells from FFA-induced apoptosis. Adenoviral mediated expression of wild type p53 potentiated FFA-induced β-cell apoptosis, whereas expression of a dominant negative p53 partly inhibited β-cell apoptosis by ∼50%. Hence, these data demonstrate that PKB activation plays an important role in promoting pancreatic β-cell survival in part via inhibition of the pro-apoptotic proteins glycogen synthase kinase-3α/β, FoxO1, and p53. This, in turn, provides novel insight into the mechanisms involved in FFA-induced β-cell apoptosis.
CRITICAL ANALYSIS OF ARTIFICIAL TEETH FOR ENDODONTIC TEACHING

The purpose of this study was to evaluate the use of artificial teeth for endodontic teaching. A questionnaire was prepared and submitted to 18 professors of Endodontics from different Brazilian universities to evaluate the following features of five cloudy resin artificial teeth: internal and external anatomy; coronal chambers regarding their size, shape and canal path; root canal regarding their size, shape and position; fulfillment of the pulp chamber and root canals by considering the texture, quantity, color, and ease of handling; resin hardness and visualization of the radiographic image. The results presented favorable opinions, in terms of internal and external anatomy, coronal pulp chambers and root canal and handling and radiographic imaging. The contents of the pulp space and hardness of the teeth were considered satisfactory. The average grade assigned to the artificial tooth quality was 8.4, in a 0-10 scale. In conclusion, the artificial teeth have potential to replace the natural teeth in endodontic teaching; however, improvements are still necessary to reach a better quality model.
Human Lectins and Their Roles in Viral Infections

Innate recognition of virus proteins is an important component of the immune response to viral pathogens. A component of this immune recognition is the family of lectins; pattern recognition receptors (PRRs) that recognise viral pathogen-associated molecular patterns (PAMPs) including viral glycoproteins. In this review we discuss the contribution of soluble and membrane-associated PRRs to immunity against virus pathogens, and the potential role of these molecules in facilitating virus replication. These processes are illustrated with examples of viruses including human immunodeficiency virus (HIV), hepatitis C virus (HCV) and Ebola virus (EBOV). We focus on the structure, function and genetics of the well-characterised C-type lectin mannose-binding lectin, the ficolins, and the membrane-bound CD209 proteins expressed on dendritic cells. The potential for lectin-based antiviral therapies is also discussed.
Private and Public Displays of Affection Among Interracial and Intrarracial Adolescent Couples

Most of the literature on romantic relationships focuses on adults. In addition, those who study the differences between interracial and intrarracial couples often look at only two racial groups, mainly black and white couples. Using the National Longitudinal Study of Adolescent Health (Add Health), a nationally representative sample of adolescents in the United States (1994-1995), We examine how interracial versus intrarracial couples vary in three dimensions of romantic involvement among white, African American, Hispanic, Native American, and Asian adolescents. We analyze three dimensions of relationship involvement: public display, private display, and intimate (physical) contact. Our preliminary findings suggest that interracial couples are less likely to exhibit public display of affection, compared to intrarracial couples, while they are not different from intrarracial couples on the two other dimensions. However, when contextual factors are taken into account, these differences tend to disappear. Adolescents’ romantic relationships thus mirror the continuing reluctance of broad social norms that reject racial mixing.
Implementing traffic shaping and link scheduling on a high-performance server

This paper examines the implementation of traffic shaping and link scheduling mechanisms on an end-host server. We first compare various implementation strategies, and then present a network interface architecture with dedicated support for traffic shaping and link scheduling for use in end-host servers. This results in significant load reduction on the server CPU, as shaping and scheduling tasks can execute concurrently on the network interface. This allows the server to provide very fine-grain link multiplexing, and consequently more diverse set of QoS guarantees for a large number of flows. We present two alternative implementations of our architecture. The first uses custom hardware while the second is implemented as a software component running on a dedicated processor on the network interface.
Online Supplemental Material

Figures S1-S4 show transmission electron microscopy of stratifying immortalized wt and P0 keratinocytes, P1c-MT cosedimentation, P1c-/-keratinocytes transfected with P1c variants lacking the IF-binding domain and full-length P1c without drug challenge, and glucose uptake measured after MT disruption by colchicine, respectively. Figure S5 presents inhibition of MAP-MT interaction using plectin fragment p16-21. Details about the primers used for RT-PCR analysis are shown in Table S1. Video 1 shows time-lapse images of EGFP-tubulin-transfected wt and P0 keratinocytes.
Multi-Armed Bandits for Addressing the Exploration/Exploitation Trade-off in Self Improving Learning Environment

This project proposes the use of machine learning techniques such as Multi-Armed Bandits to implement self-improving learning environments. The goal of a self-improving learning environment is to perform good pedagogical choices while measuring the efficiency of these choices. The modeling of students is done using the LFA model and fitted on a dataset of university courses to allow to simulate students. Three experiments with simulated students are carried out and show that the Multi-Armed Bandit approach improves learning outcomes.
Local control of phosphatidylinositol 4-phosphate signaling in the Golgi apparatus by Vps74 and Sac1 phosphoinositide phosphatase

Signaling by phosphatidylinositol 4-kinases (PI4Ks) in the Golgi apparatus controls lipid homeostasis and protein-sorting pathways. Signaling is shown to be terminated on the medial cisterna by a complex of a PI4K effector, Vps74, and Sac1, the major PtdIns4P phosphatase in the cell.
Transforming Growth Factor β (TGFβ) Mediates Schwann Cell Death In Vitro and In Vivo: Examination of c-Jun Activation, Interactions with Survival Signals, and the Relationship of TGFβ-Mediated Death to Schwann Cell Differentiation

In some situations, cell death in the nervous system is controlled by an interplay between survival factors and negative survival signals that actively induce apoptosis. The present work indicates that the survival of Schwann cells is regulated by such a dual mechanism involving the negative survival signal transforming growth factor β (TGFβ), a family of growth factors that is present in the Schwann cells themselves. We analyze the interactions between this putative autocrine death signal and previously defined paracrine and autocrine survival signals and show that expression of a dominant negative c-Jun inhibits TGFβ-induced apoptosis. This and other findings pinpoint activation of c-Jun as a key downstream event in TGFβ-induced Schwann cell death. The ability of TGFβ to kill Schwann cells, like normal Schwann cell death in vivo, is under a strong developmental regulation, and we show that the decreasing ability of TGFβ to kill older cells is attributable to a decreasing ability of TGFβ to phosphorylate c-Jun in more differentiated cells.
Mild Cognitive Impairment

Purpose of Review: The term mild cognitive impairment (MCI) is used to describe older subjects with demonstrable cognitive impairment who have not crossed the threshold for dementia. Because patients with MCI have an increased risk of developing dementia, especially Alzheimer disease (AD), there is significant interest in the clinical characterization of these subjects and in understanding the pathophysiology of the transition from MCI to AD.Recent Findings: The MCI syndrome, as an expression of an incipient disorder that may lead to dementia, is extremely heterogeneous and may coexist with systemic, neurologic, or psychiatric disorders that can cause cognitive deficits. Recent clinical criteria were designed to take into account the different forms of clinical presentation of the syndrome, and introduced the possible contribution of biomarkers to the clinical diagnosis. Bedside diagnosis of MCI can be difficult, since patients who report having cognitive problems may have normal scores in global cognitive scales or in brief neuropsychological instruments.Summary: This article presents the evolution of the clinical concept of MCI, the operationalization of its current definitions, the development of biomarkers that can help to identify an underlying neurodegenerative process as the etiology of the syndrome, and its proposed treatments.
Are Facial Expressions Reproducible?

Objectives To determine the extent of reproducibility of five facial expressions. Design Thirty healthy Caucasian volunteers (15 males, 15 females) aged 21 to 30 years had 20 landmarks highlighted on the face with a fine eyeliner pencil. Subjects were asked to perform a sequence of five facial expressions that were captured by a three-dimensional camera system. Each expression was repeated after 15 minutes to investigate intrasession expression reproducibility. To investigate intersession expression reproducibility, each subject returned 2 weeks after the first session. A single operator identified 3-dimensional coordinate values of each landmark. A partial ordinary procrustes analysis was used to adjust for differences in head posture between similar expressions. Statistical analysis was undertaken using analysis of variance (linear mixed effects model). Results Intrasession expression reproducibility was least between cheek puffs (1.12 mm) and greatest between rest positions (0.74 mm). The reproducibility of individual landmarks was expression specific. Except for the lip purse, the reproducibility of facial expressions was not statistically different within each of the two sessions. Rest position was most reproducible, followed by lip purse, maximal smile, natural smile, and cheek puff. Subjects did not perform expressions with the same degree of symmetry on each occasion. Female subjects demonstrated significantly better reproducibility with regard to the maximal smile than males (p = .036). Conclusions Under standardized conditions, intrasession expression reproducibility was high. Variation in expression reproducibility between sessions was minimal. The extent of reproducibility is expression specific. Differences in expression reproducibility exist between males and females.
Effects of the F4TCNQ-Doped Pentacene Interlayers on Performance Improvement of Top-Contact Pentacene-Based Organic Thin-Film Transistors

In this paper, the top-contact (TC) pentacene-based organic thin-film transistor (OTFT) with a tetrafluorotetracyanoquinodimethane (F4TCNQ)-doped pentacene interlayer between the source/drain electrodes and the pentacene channel layer were fabricated using the co-evaporation method. Compared with a pentacene-based OTFT without an interlayer, OTFTs with an F4TCNQ:pentacene ratio of 1:1 showed considerably improved electrical characteristics. In addition, the dependence of the OTFT performance on the thickness of the F4TCNQ-doped pentacene interlayer is weaker than that on a Teflon interlayer. Therefore, a molecular doping-type F4TCNQ-doped pentacene interlayer is a suitable carrier injection layer that can improve the TC-OTFT performance and facilitate obtaining a stable process window.
OVERALL ELASTIC PROPERTIES OF POLYSILICON FILMS: A STATISTICAL INVESTIGATION OF THE EFFECTS OF POLYCRYSTAL MORPHOLOGY

In this paper we investigate the effects of polycrystal morphology on the overall properties of polysilicon. Focusing on two-dimensional representative volume elements (RVEs) of textured films, we numerically generate digital polycrystal morphologies through Voronoi tessellations and assume the in-plane orientation of the crystal lattice of silicon grains to be randomly distributed. First, we show how a regularization provision for the Voronoi tessellations, adopted in order to better match the grain boundary (GB) geometry featured by actual polysilicon films, affects the statistics of an internal length-scale which naturally emerges because of the presence of GBs. Second, we provide a numerical homogenization technique to estimate the overall in-plane elastic moduli of the polysilicon film and compare the outcomes with standard Voigt and Reuss bounds. Through this comparison, we furnish a way to also estimate the size of the RVE to get effective results. Third, through Monte Carlo simulations we investigate the effect of microstructural fluctuations on the scattering of the overall elastic moduli of polysilicon. We show that even when the RVE appears to be representative for a single polycrystal realization, the RVE might not be representative if one looks at the extreme values of the aforementioned scattered elastic moduli.
The Support Vector Machine Based on the Principal Component in the Credit Management of Electronic Commerce

The paper applies support vector machine (SVM) based on principal component to credit management in E-commerce, and in this paper not only principal component analysis is used to do operation of dimension reduction in multi-dimensional variable system so as to get low-dimensional variable system characters with a high precision, but also the favorable generalization capability of SVM to small sample is adopted. Experiment results indicate that the way of managing E-commerce by means of integrating principal component analysis with SVM is simpler and more effective than that of traditional single using SVM.