Miracle-dz/UniFAR-FTUs huggingface dataset:
Acute fibrinous and organizing pneumonia: a histological pattern of lung injury and possible variant of diffuse alveolar damage.

CONTEXT The histologic patterns of diffuse alveolar damage (DAD), bronchiolitis obliterans with organizing pneumonia (BOOP), and eosinophilic pneumonia (EP) are well-recognized histologic patterns of lung injury associated with an acute or subacute clinical presentation. We have recognized acute fibrinous and organizing pneumonia (AFOP) as a histologic pattern, which also occurs in this clinical setting but does not meet the classic histologic criteria for DAD, BOOP, or EP and may represent an underreported variant. OBJECTIVE To investigate the clinical significance of the AFOP histologic pattern and to explore its possible relationship to other disorders, including DAD and BOOP. DESIGN Open lung biopsy specimens and autopsy specimens were selected from the consultation files of the Armed Forces Institute of Pathology, which showed a dominant histologic pattern of intra-alveolar fibrin and organizing pneumonia. Varying amounts of organizing pneumonia, type 2 pneumocyte hyperplasia, edema, acute and chronic inflammation, and interstitial widening were seen. Cases with histologic patterns of classic DAD, BOOP, abscess formation, or eosinophilic pneumonia were excluded. To determine the clinical behavior of patients with this histologic finding, clinical and radiographic information and follow-up information were obtained. Statistical analysis was performed using Kaplan-Meier and chi(2) analysis. RESULTS Seventeen patients (10 men, 7 women) with a mean age of 62 years (range, 33-78 years) had acute-onset symptoms of dyspnea (11), fever (6), cough (3), and hemoptysis (2). Associations believed to be clinically related to the lung disease included definitive or probable collagen vascular disease (3), amiodarone (1), sputum culture positive for Haemophilus influenza (1), lung culture positive for Acinetobacter sp. (1), lymphoma (1), hairspray (1), construction work (1), coal mining (1), and zoological work (1). Six patients had no identifiable origin or association. Follow-up revealed 2 clinical patterns of disease progression: a fulminate illness with rapid progression to death (n = 9; mean survival, 0.1 year) and a more subacute illness, with recovery (n = 8). Histologic analysis and initial symptoms did not correlate with eventual outcome, but 5 of the 5 patients who required mechanical ventilation died (P =.007). CONCLUSIONS Acute fibrinous and organizing pneumonia is a histologic pattern associated with a clinical picture of acute lung injury that differs from the classic histologic patterns of DAD, BOOP, or EP. Similar to these patterns of acute lung injury, the AFOP pattern can occur in an idiopathic setting or with a spectrum of clinical associations. The overall mortality rate is similar to DAD and therefore may represent a histologic variant; however, AFOP appears to have 2 distinct patterns of disease progression and outcome. The need for mechanical ventilation was the only parameter that correlated with prognosis. None of the patients with a subacute clinical course required mechanical ventilation.
Efficient content-based information retrieval: a new similarity measure for multimedia data

Content-based information retrieval of multimedia data is a great and attractive challenge which raises numerous research activities. As multimedia data become ubiquitous in our daily lives, information retrieval systems have to adapt their retrieval performance to different situations in order to efficiently satisfy the users' information needs anytime and anywhere. To enhance the content-based multimedia information retrieval process, we propose an efficient similarity measure based on flexible feature representations. We define the similarity model for content-based information retrieval and show its feasibility on real world multimedia data. Furthermore, we briefly discuss future research directions which we plan to investigate.
On Church's Thesis in Cubical Assemblies

We show that Church’s thesis, the axiom stating that all functions on the naturals are computable, does not hold in the cubical assemblies model of cubical type theory. We show that nevertheless Church’s thesis is consistent with univalent type theory by constructing a lex modality in cubical assemblies such that Church’s thesis holds in the corresponding reflective subuniverse.
Universal spaces of parameters for complex Grassmann manifolds $G_{q+1,2}$

Buchstaber and Terzic introduced a notion of universal space of parameters $\mathcal{F}$ for a manifold $M^{2n}$, which has an effective action of compact torus $T^k$ , $k \leq n$ with some additional properties. with special properties. This space is needed to construction of factor $M^{2n}/T^k$. Buchstaber and Terzic constructed the universal space of parameters for $G_{5,2}$. In this work we construct universal space of parameters for complex Grassmann manifold $G_{q+1,2}$. Our construction is based on the construction of moduli space of stable curves of genus zero with $q+1$ marked points due to Salamon, McDuff and Hofer.
Flow field around a confined active droplet

We present here first-of-a-kind experimental measurements of the flow field around a swimming water droplet, using confocal PIV in three dimensions. The droplet is denser than the continuous oil phase, and swims close and parallel to the bottom wall. The measured flow field is first quantitatively characterized and compared to the flow field obtained for an axisymmetric swimmer in unbounded flow. Important qualitative differences are observed, in particular the emergence of a strong isotropic radial flow field in the planes parallel to the wall. These fundamental differences stress the critical impact of confinement on the flow field around the swimming droplet. We then propose an analytical formulation, based on a reduced order description of the swimming droplet in terms of fundamental hydrodynamic singularities as well as the classical method of images. This model is able to account exactly for the effect of the wall and provides a simplified description of the flow field as the superposition of axisymmetric dipole and quadrupole singularities. We demonstrate that this simplified description quantitatively captures the effect of the wall on the dipolar and quadrupolar components of the flow field. Further including the confinement-induced asymmetry of the concentration field responsible for the droplet's Marangoni propulsion, our model is also able to account for the monopolar contribution to the experimental flow field which drives the dominant far-field signature of the droplet.
Generalized Nariai Solutions for Yang-type Monopoles

A detailed study of the geometries that emerge by a gravitating generalized Yang monopole in even dimensions is carried out, in particular, those which present black hole and cosmological horizons. This two-horizon system is thermally unstable. The process of thermalization will drive both horizons to coalesce. This limit is what is profusely studied in this paper. It is shown that even though coordinate distance shrinks to zero, physical distance does not. So, there is some remaining space whose geometry has been computed and identified as a generalized Nariai solution. The thermal properties of this new spacetime are then calculated. Topics such as the elliptical relation between radii of spheres in the geometry or a discussion about whether a mass-type term should be present in the line element or not are also included.
A dielectric loaded millimeter wave antenna array for 60 GHz communication systems

A Dielectric loaded millimeter wave antenna array of 1 × 4 elements fed by slotted substrate integrated waveguide for 60 GHz communication systems is presented. Only slotted SIW design cannot provide a wide bandwidth and hence to achieve wide bandwidth the concept of dielectric loading is adopted. The cumulative effect results in wide bandwidth. This design uses a complete SIW feed network to minimize the effect of back radiations. The results show an impedance bandwidth of 10.50 % around 60 GHz, having a gain up to 10.60 dBi, and an estimated efficiency of 75 %. The designs are simulated in CST Microwave Studio and verified in HFSS simulator.
DISTINGUISHING PRIME NUMBERS FROM COMPOSITE NUMBERS : THE STATE OF THE ART IN 2004

This paper compares 21 methods to distinguish prime numbers from composite numbers. It answers the following questions for each method: Does the method certify primality? Conjecturally certify primality? Certify compositeness? Are certificates conjectured to exist for all inputs? Proven to exist for all inputs? Found deterministically for all inputs? Is a certificate verified in essentially linear time? Essentially quadratic time? Et cetera. Is a certificate found immediately? In essentially linear time? Essentially quadratic time? Et cetera. In brief, how does the method work? When and where was the method published?
Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications

ABSTRACT Small extracellular vesicles (sEVs) from mesenchymal stromal/stem cells (MSCs) are transiting rapidly towards clinical applications. However, discrepancies and controversies about the biology, functions, and potency of MSC-sEVs have arisen due to several factors: the diversity of MSCs and their preparation; various methods of sEV production and separation; a lack of standardized quality assurance assays; and limited reproducibility of in vitro and in vivo functional assays. To address these issues, members of four societies (SOCRATES, ISEV, ISCT and ISBT) propose specific harmonization criteria for MSC-sEVs to facilitate data sharing and comparison, which should help to advance the field towards clinical applications. Specifically, MSC-sEVs should be defined by quantifiable metrics to identify the cellular origin of the sEVs in a preparation, presence of lipid-membrane vesicles, and the degree of physical and biochemical integrity of the vesicles. For practical purposes, new MSC-sEV preparations might also be measured against a well-characterized MSC-sEV biological reference. The ultimate goal of developing these metrics is to map aspects of MSC-sEV biology and therapeutic potency onto quantifiable features of each preparation.
Knowledge and practice of radiation safety among health professionals in Trinidad

Objective: To determine the practices and knowledge of radiation safety measures among health care providers in tertiary institutions in Trinidad. Design & Method: A cross-sectional survey of health care professionals within two public hospitals was conducted using a questionnaire distributed to individuals working in Cardiology, General Surgery, Internal medicine, Orthopaedics, Radiology and Urology who require the use of ionizing radiation machines. The questionnaire comprised of 30 questions divided into five subcategories including demographic data, usage of the ionizing radiation machines, basic knowledge, and attitude towards personal protective equipment as well as radiation exposure measurement. Questionnaire results were tabulated and analysed using Microsoft Excel and Stata v11 with comparative statistical analysis being done using the one-way analysis of variance test. Results: A total of 118 health care professionals participated in this study. The majority (85/118 (72%)) of individuals revealed that they had no formal training regarding safe practices when working with ionizing radiation despite the daily use of the fluoroscopy machines by at least 25% of participants. Individuals who had formal training in the use of ionizing radiation were found to score significantly higher than those without training (p < 0.0001). Participants’ knowledge regarding the proper positioning of the C-arm image intensifier to reduce radiation exposure was low with 46% of individuals providing a correct response. Conclusions: The level of knowledge among the individuals who participate in the operation of ionizing radiation equipment throughout the country is low. The benefit of training in the use of the C-arm image intensifier is highlighted by the revelation that the individuals who had formal training in the use of these machines performed better than those individuals without training. Annual recertification courses should be implemented such that individuals are kept abreast with current changes and reminded of commonly neglected safety practices.
Do dysfunctional posttraumatic cognitions play a mediating role in trauma adjustment? Findings from interpersonal and accidental trauma samples of children and adolescents

ABSTRACT Background: Trauma adjustment varies in children and adolescents. Studies on objective risk factors of posttraumatic stress symptoms (PTSS) yielded inconsistent results. Dysfunctional posttraumatic cognitions (PTCs) might play a mediating role between risk factors and posttraumatic symptomatology. Objective: To investigate the interplay of the characteristics of the trauma (e.g. trauma type), the characteristics of the individual (e.g. age, sex), and the characteristics of the social environment (e.g. parental distress, marital status) on PTSS and depression, taking the child’s dysfunctional PTCs into account as a possible mediator. Method: Structural equation modelling was used to better understand trauma adjustment in two heterogeneous samples of children and adolescents: a sample of 114 participants aged 7–16 after accidental trauma and a sample of 113 participants aged 6–17 after interpersonal trauma. Results: In the accidental trauma sample, dysfunctional PTCs mediated the positive associations of younger age and lower parental educational level on child PTSS, but not on depression. In the interpersonal trauma sample, being female positively predicted child depression. Furthermore, parental dysfunctional PTCs positively predicted both child PTSS and depression. No mediation effect of child dysfunctional PTCs was found in the interpersonal trauma sample. Child dysfunctional PTCs moderately to strongly predicted child PTSS and depression in both trauma samples. Conclusions: The impact of the characteristics of the individual and the characteristics of the social environment on child PTSS and depression might depend on the type of trauma experienced. Dysfunctional PTCs mediated between the characteristics of the individual and the characteristics of the social environment and the severity of PTSS in the aftermath of accidental trauma, but not of interpersonal trauma. HIGHLIGHTS • Dysfunctional posttraumatic cognitions (PTCs) were associated with posttraumatic stress symptoms (PTSS) and depression. • In accidentally injured children, dysfunctional PTCs mediated between the characteristics of the individual and the characteristics of the social environment and the severity of PTSS.
Randomized Pilot Trial for a Community-Based Group Stretching Exercise Program for Chronic Low Back Pain

Background Authors of meta-analyses concluded that exercise therapy appears to be slightly effective at decreasing pain and improving function in adults with chronic low back pain (CLBP), particularly in health-care populations. Similar to health-care settings, community organizations provide wellness and lifestyle modification programs. Different versions of the Young Men’s Christian Association (YMCA) Y’s Way to a Healthy Back program were offered from 1974 to 2004. Champions of the YMCA program and authors of the pilot study designed a Healthy Back Curriculum to update and reintroduce the program. Objective: The research aim of this randomized pilot trial was to investigate the feasibility of a follow-up larger randomized controlled trial on the program’s effectiveness for CLBP. The randomized pilot trial addressed subject recruitment, retention, and subject compliance with protocol. Methods: The pilot trial employed a 2-arm parallel group randomized design. Seventy-eight subjects aged 18 to 64 years with low back pain on at least half the days over the previous 6 months were assigned to either (1) a group stretching exercise arm with 12 weekly classes or (2) a self-care book arm. Results: Sixty participants, 30 in each group, completed the study. Out of the 130 members who accepted invitation, 60% were eligible. Retention rate over the 24-week study in the group stretching exercise arm was 30 out of 43 participants (70%). Participants in the group stretching exercise program attended an average of 5 of the 12 classes (42%). Participants completed baseline and follow-up self-report items with no missing data. Conclusion: The pilot study did not prove to be feasible based on the prespecified benchmarks. We suggest that a larger trial should include changes gleaned from the pilot study.
Design of Fixed and Ladder Mutation Factor-Based Clonal Selection Algorithm for Solving Unimodal and Multimodal Functions

Clonal selection algorithms (CSAs) is a special class of immune algorithms (IA), inspired by the clonal selection principle of the human immune system. To improve the algorithm's ability to perform better, this CSA has been modified by implementing two new concepts called fixed mutation factor and ladder mutation factor. Fixed mutation factor maintains a constant factor throughout the process, where as ladder mutation factor changes adaptively based on the affinity of antibodies. This paper compared the conventional CLONALG, with the two proposed approaches and tested on several standard benchmark functions. Experimental results empirically show that the proposedmethods laddermutation-based clonal selection algorithm (LMCSA) and fixed mutation clonal selection algorithm (FMCSA) significantly outperform the existing CLONALG method in terms of quality of the solution, convergence speed, and solution stability.
c‐MYB‐ and PGC1a‐dependent metabolic switch induced by MYBBP1A loss in renal cancer

The tumor microenvironment may alter the original tumorigenic potential of tumor cells. Under harsh environmental conditions, genetic alterations conferring selective advantages may initiate the growth of tumor subclones, providing new opportunities for these tumors to grow. We performed a genetic loss‐of‐function screen to identify genetic alterations able to promote tumor cell growth in the absence of glucose. We identified that downregulation of MYBBP1A increases tumorigenic properties under nonpermissive conditions. MYBBP1A downregulation simultaneously activates PGC1α, directly by alleviating direct repression and indirectly by increasing PGC1α mRNA levels through c‐MYB, leading to a metabolic switch from glycolysis to OXPHOS and increased tumorigenesis in low‐glucose microenvironments. We have also identified reduced MYBBP1A expression in human renal tumor samples, which show high expression levels of genes involved in oxidative metabolism. In summary, our data support the role of MYBBP1A as a tumor suppressor by regulating c‐MYB and PGC1α. Therefore, loss of MYBBP1A increases adaptability spanning of tumors through metabolic switch.
Wave functions, evolution equations and evolution kernels from light ray operators of QCD

The widely used nonperturbative wave functions and distribution functions of QCD are determined as matrix elements of light-ray operators. These operators appear as large momentum limit of nonlocal hadron operators or as summed up local operators in light-cone expansions. Nonforward one-particle matrix elements of such operators lead to new distribution amplitudes describing both hadrons simultaneously. These distribution functions depend besides other variables on two scaling variables. They are applied for the description of exclusive virtual Compton scattering in the Bjorken region near forward direction and the two meson production process. The evolution equations for these distribution amplitudes are derived on the basis of the renormalization group equation of the considered operators. This includes that also the evolution kernels follow from the anomalous dimensions of these operators. Relations between different evolution kernels (especially the Altarelli-Parisi and the Brodsky-Lepage) kernels are derived and explicitly checked for the existing two-loop calculations of QCD. Technical basis of these results are support and analytically properties of the anomalous dimensions of light-ray operators obtained with the help of the $\alpha$-representation of Green's functions.
Ergonomic stressors and upper extremity musculoskeletal disorders in automobile manufacturing: a one year follow up study

Aims: To estimate the one year cumulative incidence and persistence of upper extremity (UE) soft tissue disorders, in a fixed cohort of automotive manufacturing workers, and to quantify their associations with ergonomic exposures. Methods: At baseline and at follow up, cases of UE musculoskeletal disorders were determined by interviewer administered questionnaire and standardised physical examination of the upper extremities. The interview obtained new data on psychosocial strain and updated the medical and work histories. An index of exposure to ergonomic stressors, obtained at baseline interview, was the primary independent variable. Cumulative incidence and persistence of UE disorders (defined both by symptoms and by physical examination plus symptoms) were analysed in relation to baseline ergonomic exposures, adjusting for other covariates. The incidence of new disorders was modelled using multivariate proportional hazards regression among workers who were not cases in the first year and the prevalence on both occasions was modelled by repeated measures analysis. Results: A total of 820 workers (69% of eligible cohort members) was examined. Follow up varied slightly by department group but not by baseline exposure level or other characteristics. Among the non-cases at baseline, the cumulative incidence of UE disorders was 14% by symptoms and 12% by symptoms plus examination findings. These rates increased with index of physical exposures primarily among subjects who had the same jobs at follow up as at baseline. Increased exposure during follow up increased risk of incidence. The persistence of UE disorders from baseline to follow up examination was nearly 60% and somewhat associated with baseline exposure score. Conclusions: These longitudinal results confirm the previous cross sectional associations of UE musculoskeletal disorders with exposure to combined ergonomic stressors. The exposure-response relation was similar for incident cases defined by symptoms alone and those confirmed by physical examination.
High Content Imaging and Analysis Enable Quantitative In Situ Assessment of CYP3A4 Using Cryopreserved Differentiated HepaRG Cells

High-throughput imaging-based hepatotoxicity studies capable of analyzing individual cells in situ hold enormous promise for drug safety testing but are frequently limited by a lack of sufficient metabolically competent human cells. This study examined cryopreserved HepaRG cells, a human liver cell line which differentiates into both hepatocytes and biliary epithelial cells, to determine if these cells may represent a suitable metabolically competent cellular model for novel High Content Analysis (HCA) applications. Characterization studies showed that these cells retain many features characteristic of primary human hepatocytes and display significant CYP3A4 and CYP1A2 induction, unlike the HepG2 cell line commonly utilized for HCA studies. Furthermore, this study demonstrates that CYP3A4 induction can be quantified via a simple image analysis-based method, using HepaRG cells as a model system. Additionally, data demonstrate that the hepatocyte and biliary epithelial subpopulations characteristic of HepaRG cultures can be separated during analysis simply on the basis of nuclear size measurements. Proof of concept studies with fluorescent cell function reagents indicated that further multiparametric image-based assessment is achievable with HepaRG. In summary, image-based screening of metabolically competent human hepatocyte models cells such as HepaRG offers novel approaches for hepatotoxicity assessment and improved drug screening tools.