Miracle-dz/UniFAR-FTUs huggingface dataset:
Welfare Reform: Prescription for Abuse? A Report on New Research Studies Documenting the Relationship of Domestic Violence and Welfare, 19 L. & Pol'y 123 (1997)

Anecdotally, welfare-to-work programs have documented that domestic violence serves as a welfare-to-work barrier by partners' interference with education, training and work, or by physical or mental trauma which also prevents employment. Four new research studies, which, although using different methods, including random and nonrandom surveys of welfare caseloads and random neighborhood surveys, document high and remarkably consistent prevalence of domestic violence within welfare caseloads. Although much more needs to be known, the prevalence of domestic violence in these women's lives requires specific domestic violence-sensitive welfare policies lest women become injured during the welfare-to-work process. Language: en
Improving the Doctor-Patient Relationship in China: The Role of Balint Groups

Objective: Doctor-patient relationships in China have been deteriorating for the past 10 years. Many Chinese doctors are involved in tense and conflictual doctor-patient relationships. Most patients do not trust doctors or other medical staff and physical attacks on these professionals have become a common event. The Balint group offers a better understanding of the doctor-patient relationship in a safe environment and relieves the doctors from the daily stress. Method: This article (1) describes the specifics of Balint work in China, (2) reports experiences from the first International Balint Conference in China, and (3) compares these experiences with the doctor-patient relationship described by Michael and Enid Balint in the 1950s. Results: Chinese doctors have a great need to communicate, to share their own feelings of powerlessness, helplessness, frustration, and anger. The Balint method is highly appreciated in China. All participants experienced the 2½-day meeting as very helpful. Also, in China, Balint work as relationship work in the analytical group process fosters the ability for introspection alongside openness, unconscious processes, “thinking outside the box,” “courage of one's own stupidity,” and “beginner's spirit,” thus promoting the individuation, the “small but significant change in the personality of the doctor. ” Conclusions: Perhaps Balint work in China is a contribution to the integration of traditional Chinese virtues: benevolence, tolerance, magnanimity, and prudence with modern medicine. Balint work could be an alternative to the outcome-oriented pressure to perform and to the machine paradigm of biomedicine.
Nucleation of rupture under slip dependent friction law: Simple models of fault zone

The initiation of frictional instability is investigated for simple models of fault zone using a linearized perturbation analysis. The fault interface is assumed to obey a linear slip-weakening law. The fault is initially prestressed uniformly at the sliding threshold. In the case of antiplane shear between two homogeneous linearly elastic media, space-time and spectral solutions are obtained and shown to be consistent. The nucleation is characterized by (1) a long-wavelength unstable spectrum bounded by a critical wave number; (2) an exponential growth of the unstable modes; and (3) an induced off-fault deformation that remains trapped within a bounded zone in the vicinity of the fault. These phenomena are characterized in terms of the elastic parameters of the surrounding medium and a nucleation length that results from the coupling between the frictional interface and the bulk elasticity. These results are extended to other geometries within the same formalism and implications for three-dimensional rupture are discussed. Finally, internal fault structures are investigated in terms of a fault-parallel damaged zone. Spectral solutions are obtained for both a smooth and a layered distribution of damage. For natural faults the nucleation is shown to depend strongly on the existence of a internal damaged layer. This nucleation can be described in terms of an effective homogeneous model. In all cases, frictional trapping of the deformation out of the fault can lead to the property that arbitrarily long wavelengths remain sensitive to the existence of a fault zone.
Uniform-Field Flicker Masking in Control and Specifically-Disabled Readers

Possible transient-system deficiencies in subjects with specific reading disabilities (SRDs) were investigated in groups of 13-year-old SRDs and control normal readers. In experiment 1, in which a 6 Hz uniform-field flicker (UFF) mask and a stationary test stimulus were used, it was found that the overall effect of UFF masking was to reduce differences in contrast sensitivity between SRDs and normal readers. In experiments 2a and 2b, with UFF masks of 6 and 20 Hz and a 6 Hz moving (experiment 2a) or flickering (experiment 2b) test stimulus, contrast sensitivity in both groups was decreased in the presence of the 6 Hz UFF mask. Only the control group, however, showed a further decrease in sensitivity with the 20 Hz UFF mask. This indicates that the groups differ in terms of a mechanism sensitive to high temporal frequencies. A 20 Hz counterphase flickering test stimulus was used in experiment 3 in the presence of 6 Hz UFF, and it was found that SRDs are less sensitive than controls to 20 Hz flicker across all spatial frequencies used. The 6 Hz mask, however, did not differentially affect the two groups. These findings provide further evidence for a transient-system deficit in the visual systems of SRDs, but also suggest a more complex situation by showing that the two groups differ in a high-temporal-frequency mechanism.
Measuring temporal stability of positron emission tomography standardized uptake value bias using long-lived sources in a multicenter network

Abstract. Positron emission tomography (PET) is a quantitative imaging modality, but the computation of standardized uptake values (SUVs) requires several instruments to be correctly calibrated. Variability in the calibration process may lead to unreliable quantitation. Sealed source kits containing traceable amounts of Ge68/Ga68 were used to measure signal stability for 19 PET scanners at nine hospitals in the National Cancer Institute’s Quantitative Imaging Network. Repeated measurements of the sources were performed on PET scanners and in dose calibrators. The measured scanner and dose calibrator signal biases were used to compute the bias in SUVs at multiple time points for each site over a 14-month period. Estimation of absolute SUV accuracy was confounded by bias from the solid phantoms’ physical properties. On average, the intrascanner coefficient of variation for SUV measurements was 3.5%. Over the entire length of the study, single-scanner SUV values varied over a range of 11%. Dose calibrator bias was not correlated with scanner bias. Calibration factors from the image metadata were nearly as variable as scanner signal, and were correlated with signal for many scanners. SUVs often showed low intrascanner variability between successive measurements but were also prone to shifts in apparent bias, possibly in part due to scanner recalibrations that are part of regular scanner quality control. Biases of key factors in the computation of SUVs were not correlated and their temporal variations did not cancel out of the computation. Long-lived sources and image metadata may provide a check on the recalibration process.
The Role of a Novel p97/Valosin-containing Protein-interacting Motif of gp78 in Endoplasmic Reticulum-associated Degradation*

Improperly folded proteins in the endoplasmic reticulum (ER) are eliminated via ER-associated degradation, a process that dislocates misfolded proteins from the ER membrane into the cytosol, where they undergo proteasomal degradation. Dislocation requires a subclass of ubiquitin ligases that includes gp78 in addition to the AAA ATPase p97/VCP and its cofactor, the Ufd1-Npl4 dimer. We have previously reported that gp78 interacts directly with p97/VCP. Here, we identify a novel p97/VCP-interacting motif (VIM) within gp78 that mediates this interaction. We demonstrate that the VIM of gp78 recruits p97/VCP to the ER, but has no effect on Ufd1 localization. We also show that gp78 VIM interacts with the ND1 domain of p97/VCP that was shown previously to be the binding site for Ufd1. To evaluate the role of Ufd1 in gp78-p97/VCP-mediated degradation of CD3δ, a known substrate of gp78, RNA interference was used to silence the expression of Ufd1 and p97/VCP. Inhibition of p97/VCP, but not Ufd1, stabilized CD3δ in cells that overexpress gp78. However, both p97/VCP and Ufd1 appear to be required for CD3δ degradation in cells expressing physiological levels of gp78. These results raise the possibility that Ufd1 and gp78 may bind p97/VCP in a mutually exclusive manner and suggest that gp78 might act in a Ufd1-independent degradation pathway for misfolded ER proteins, which operates in parallel with the previously established p97/VCP-Ufd1-Npl4-mediated mechanism.
Beyond Whiffle-Ball Bats: Addressing Identity Crime in an Information Economy, 26 J. Marshall J. Computer & Info. L. 47 (2008)

The article discusses the challenges to the protection of private personal information in the age of rapid technological changes and advances with a particular focus on the explosion of Identity Theft Crime (IDC). The paper highlights the compartmentalized and imbalanced roles that the free market and law enforcement (LE) play in response to this emerging threat to privacy, the implications of this dynamic, and recommendations for improving the societal risk management of Identity Crime.
The identification of Dictyostelium phosphoproteins altered in response to the activation of RasG

Dictyostelium RasG has been implicated in the regulation of a variety of cellular processes, including the initiation of development, cell movement, and cytokinesis, but the molecular components of the signaling pathways involved are largely unknown. We used a tetracycline‐regulated protein expression system to study the effect of activated RasG, RasG(G12T), expression on the phosphorylation state of Dictyostelium proteins. Over 70 vegetative phosphoprotein components were resolved by two‐dimensional (2‐D) immunoblot analysis and of these 16 phosphothreonine and three phosphotyrosine protein components were found to reproducibly change upon RasG(G12T) expression. Thirteen of these were recovered from 2‐D gels and identified by mass spectrometry of in‐gel tryptic digestions. The proteins identified include the signaling proteins RasGEF‐R and protein kinase B, the adhesion protein DdCAD‐1, the cytoskeletal protein actin, the mitochondrial division protein FtsZA, and proteins involved in translation and metabolism. In addition to the direct demonstration of the phosphorylation of putative downstream targets of RasG activation, these findings reveal previously undetected phosphorylation of several proteins.
BMP-14 Deficiency Inhibits Long Bone Fracture Healing: A Biochemical, Histologic, and Radiographic Assessment

Objectives: Bone morphogenetic proteins (BMPs) represent a distinct subset of the transforming growth factor-β family best known for their role in joint formation and bone growth, and several recent clinical trials have begun to look at their efficacy in the augmentation of fracture healing. The goal of this research is to examine the effect of BMP-14, also known as growth differentiation factor-5 and cartilage- derived morphogenetic protein-1 (GDF-5, CDMP-1) on fracture healing by studying the long bone repair process in mice with a deficiency in this signaling peptide. Methods: The animal model used for these studies was the BMP-14 (−/−) brachypodism (bp) mouse. Phenotypically normal heterozygous (±) littermates were used as controls. Closed mid shaft femur fractures were created and stabilized with intramedullary fixation in 8-week-old female mice. Forty-eight mice per genotype group were examined. On postoperative days 4, 7, 10, 14, 21, 28, 35, and 42, the mice were killed and the femurs and repair tissue were harvested for analysis. At each time point, the fracture sites were analyzed radiographically, histologically, and biochemically. For all quantitative analyses, the data were normalized and analyzed statistically using a 2-factor ANOVA test. Results: Biochemically, peak values of normalized proteoglycan content were approximately 3 times less in the mutant fractures early in the time course of healing compared with the controls (P < 0.05). Histologically, BMP-14-deficient fractures exhibited a delay in peak area cell density, callus organization, and bone formation compared with controls. Radiographic analysis demonstrated that the peak callus was 2 weeks delayed and approximately 2 times less in the mutants compared with controls (P < 0.05). Radiographic grading of callus also demonstrated a significant difference after day 14. Conclusions: Based on histologic, radiographic, and biochemical analysis, BMP-14-deficient mice display a short-term delay in healing of approximately 1 to 2 weeks. The observed abnormalities seem to be the result of a delay in cellular recruitment and chondrocyte differentiation in the early stages fracture repair in the absence of BMP-14. These results support the hypothesis that BMP-14 deficiency leads to a delay in fracture healing. Further studies are warranted to more closely examine the role of BMP-14 in normal fracture healing and the mechanism by which it works.
Studies of antigens in Plasmodium yoelii

Summary Antigens of three lines of the rodent malaria parasite Plasmodium yoelii have been studied using crossed immunoelectrophoresis. P. y. yoelii line A1 is a mild line which is restricted to reticulocytes. P. y. yoelii line YM and P. y. nigeriensis line D1 are virulent infections which multiply in both immature and mature erythrocytes. One antigen, designated Py-1, was found to differ in its electrophoretic mobility between the lines, being fast (F) in lines A1 and YM and slow (S) in line D1. Antigen Py-1 also varied in quantity among the three lines; greater amounts were detected in parasites inhabiting mature erythrocytes than in those in reticulocytes. These characters were stable during blood and mosquito passage.
Assistive acting movement therapy devices with pneumatic rotary-type soft actuators

Abstract Inherent compliance and assistive behavior are assumed to be essential properties for safe human-robot interaction. Rehabilitation robots demand the highest standards in this respect because the machine interacts directly with weak persons who are often sensitive to pain. Using novel soft fluidic actuators with rotary elastic chambers (REC actuators), compact, lightweight, and cost-effective therapeutic devices can be developed. This article describes modular design and control strategies for new assistive acting robotic devices for upper and lower extremities. Due to the inherent compliance and natural back-drivability of pneumatic REC actuators, these movement therapy devices provide gentle treatment, whereby the interaction forces between humans and the therapy device are estimated without the use of expensive force/torque sensors. An active model-based gravity compensation based on separated models of the robot and of the individual patient’s extremity provides the basis for effective assistive control. The utilization of pneumatic actuators demands a special safety concept, which is merged with control algorithms to provide a sufficient level of safeness and to catch any possible system errors and/or emergency situations. A self-explanatory user interface allows for easy, intuitive handling. Prototypes are very comfortable for use due to several control routines that work in the background. Assistive devices have been tested extensively with several healthy persons; the knee/hip movement therapy device is now under clinical trials at the Clinic for Orthopaedics and Trauma Surgery at the Klinikum Stuttgart.
A Reliable Approach to Diabetic Neuroischemic Foot Wounds: Below-the-Knee Angiosome-Oriented Angioplasty

Purpose To evaluate the clinical benefit in wound healing and limb preservation after primary below-the-knee angioplasty guided by an angiosome model of perfusion in diabetic patients with neuroischemic foot ulcers. Methods From September 2001 to April 2010, 232 limb-threatening neuroischemic wounds in 208 diabetic patients (147 men; mean age 74.3 years, range 42–97) were treated by below-the-knee endoluminal and/or subintimal angioplasty. There were 19 (8%) TASC II type B, 80 (34%) type C, and 133 (57%) type D infrapopliteal lesions. Patients treated prior to 2005 when the angiosome-targeted revascularization protocol was introduced (89 limbs, group 1) were compared to 134 limbs treated subsequently according to the angiosome model (group 2). The angiosome-oriented group 2 included 25% procedures focusing on the anterior tibial and dorsalis pedis arteries, 68% on the posterior tibial and plantar vessels, and 7% on the peroneal arteries. Results The global technical success was 80% (187/232): 82% in group 1 and 79% in group 2. The cumulative patient survival rates were 90%, 78%, and 65% in group 1 and 93%, 82%, and 71% in group 2 at 12, 24, and 36 months, respectively (p=0.545). At the same time points, the freedom from amputation rates were 84%, 79%, and 79% in group 1 versus 90%, 89%, and 89% in group 2 (p=0.035). Clinical success rates were 76%, 68%, 68% in the group 1 and 85%, 79%, and 79% in group 2 (p=0.025). Primary and secondary patency rates did not differ between groups (p=0.813 and p=0.511). Patients in group 2 treated with angiosome-targeted revascularization had significantly better wound healing (p<0.018) and limb preservation (p<0.030). Conclusion Below-the-knee first-line angioplasty guided by an angiosome model may prove beneficial in terms of better wound healing of diabetic foot ulcers and subsequent limb salvage. Further technical improvements and large comparative studies are necessary to support these observations.
2,4,6-Trinitrophenyl 3-chlorobenzoate

In the title benzoate derivative, C13H6ClN3O8, the planes of the benzene rings form a dihedral angle of 73.59 (7)°. The central ester unit forms an angle of 20.38 (12)° with the chloro-substituted benzene ring. In the crystal, molecules are linked by weak C—H⋯O interactions, forming helical chains along [101] and [100].
Mechanisms of homeostatic plasticity in the excitatory synapse

Brain development, sensory information processing, and learning and memory processes depend on Hebbian forms of synaptic plasticity, and on the remodeling and pruning of synaptic connections. Neurons in networks implicated in these processes carry out their functions while facing constant perturbation; homeostatic responses are therefore required to maintain neuronal activity within functional ranges for proper brain function. Here, we will review in vitro and in vivo studies demonstrating that several mechanisms underlie homeostatic plasticity of excitatory synapses, and identifying participant molecular players. Emerging evidence suggests a link between disrupted homeostatic synaptic plasticity and neuropsychiatric and neurologic disorders.
Improving pharmacy students' education through enhanced experiential learning.

To the Editor: The evolution of the educational experience of pharmacy students has been a topic of much discussion and debate. One recent Viewpoint from the Journal stated that, “one of the biggest changes in pharmacy education over the past 30 years is the realization that learning from classroom lectures is insufficient to prepare students to practice pharmacy. ”1 As a fourth-year pharmacy student, I understand the importance of not only acquiring the technical skills of pharmacy practice, but also developing professional qualities such as flexibility and handling difficult situations. While I look forward to the end of my structured didactic education, I recognize that my lifelong professional education as a pharmacist is just beginning. I believe that more hands-on experiential education is needed earlier in the curriculum as it has been argued that didactic coursework and technical skills are not enough to make a good pharmacist. It is my opinion that providing these diverse experiential learning opportunities will pave the way for pharmacy students to meet ever-changing health care needs.
Therapeutic Selective Neck Dissection: A 25‐Year Review

Objectives/Hypothesis The aim of the study was to show the efficacy of selective neck dissection in combination with postoperative radiation therapy in controlling squamous cell carcinoma metastatic to the cervical lymph nodes. The study compared the incidence of recurrences and overall disease‐free survival between comparable cohorts undergoing a selective neck dissection and classic radical or modified neck dissection.
Nested immersion: Describing and classifying augmented virtual reality

We present a system, intended for automotive design review use cases, that incorporates a tracked tablet in a CAVE, where both the tablet and the CAVE provide different views and interaction possibilities within the same virtual scene. At its core, this idea is not novel. However, the literature reveals few examples of this paradigm in which virtual information is presented on a second physical device to augment an immersive virtual environment. Similarly, it is unclear where the system should be positioned within existing augmented/mixed/virtual reality taxonomies. We argue that interactions occur within a nesting of virtual and physical contexts, and that formalizing these relationships is important when attempting to understand perceptual issues. The goal of this paper is, thus, to describe the new system by proposing a scheme to formally identify sources of bias and then adapting an existing taxonomy to classify such systems.
Survivability on optical networks: Protecting the protection

Survivability in WDM optical networks has been a subject of great interest recently. The idea used over the years is to establish a protection path so that, in case of failure, this path can be used. However, these proposals take into account neither the real situation of these paths nor the requirements of the applications. In this article an approach is proposed that takes said requirements into account, using genetic algorithms and fuzzy logic, additionally considering wavelength and SRLG (Shared Risk Link Group) constraints.