Miracle-dz/UniFAR-FTUs huggingface dataset:
Phyllodes tumor of the breast treated with a multimodality approach: A single-institution retrospective analysis.

e11552 Background: Studies describing outcomes for phyllodes tumor of the breast are scarce. We explored the results of multimodality management at our institute for this disease. METHODS We retrospectively analysed our database for cases between 1994 & 2009. Adjuvant radiation was 50 Gy in 25 fractions after modified radical mastectomy (MRM) or 66 Gy equivalent after wide local excision (WLE). Chemotherapy was Ifosfamide & Anthracycline based. Survival (overall [OS] & disease free survival [DFS]) were calculated using Kaplan Meier method. Log-rank test was used to compare survival distribution. These were correlated with age (<40 vs. >40 years), tumor size (<15cm vs. >15cm), grade (benign/borderline vs. high), margin status (positive/close vs. negative) & type of surgery, WLE vs. MRM. The data was analysed using SPSS 16. RESULTS 33 patients were analysed. Median age at presentation was 36 years (range: 17-55 years). 7(21.2%) patients underwent WLE whereas 26 (78.7%) underwent MRM. 25(75%) patients had high grade tumors while 8 (25%) had borderline tumors. The median size was 13.6 cm (range: 3-24 cm). Margin was positive/close in 10 patients, free in 15 & unknown in 8. 4 patients had palliative radiation for local/metastatic disease. 7 patients received adjuvant chemotherapy & 4 received palliative chemotherapy. 2 patients achieved complete response of lung metastasis with chemotherapy, 1 achieved stable disease while one progressed after chemotherapy. Median follow up was 23 months. Estimated 5 year OS was 85% & estimated 5 year DFS was 77%. Only grade was found to correlate with survival. There was a trend for better OS with low grade - 193.6 vs. 160.2 months for high grade (p=0.08, log rank). The DFS favoured low grade - 193.6 vs. 82.9 months for high grade (p=0.02, log rank). CONCLUSIONS Phyllodes tumor of the breast is a rare & heterogeneous entity. Our results correlate with that of others for grade. An appreciable number are amenable to WLE despite large tumor size & breast conservation rates are comparable with those for carcinoma. Multiagent chemotherapy deserves further study in adjuvant & metastatic setting.
Munch: An Efficient Modularisation Strategy to Assess the Degree of Refactoring on Sequential Source Code Checkings

Software module clustering is the process of automatically partitioning the structure of the system using low-level dependencies in the source code, to improve the system's structure. There have been a large number of studies using the search-based software engineering approach to solve the software module clustering problem. This paper introduces the concept of seeding to modularise sequential source code software versions, in order to measure the degree of refactoring. We have developed a software clustering tool called Munch. We evaluated the efficiency of the modularisation by performing a set of experiments on the dataset. We initially experimented with few fitness functions and as a result chose what we believe the most suitable function EVMD to test on our unique dataset. The results of the experiments provide evidence to support the seeding strategy.
A multidimensional analysis of trends in educational technology

This paper summarizes some of the work that has been carried out within the eMadrid research network in the last four years in the area of educational technology at Universidad Carlos III de Madrid. In order to organize the findings and identify future trends and possibilities, a framework space is used with three dimensions: physical-digital, local-global, and formal-informal. Research results are presented along the three dimensions and possible future developments are suggested in this framework.
The Selective Inhibition of Serotonin‐ Induced Contractions of Rabbit Cerebral Vascular Smooth Muscle by Calcium‐ Antagonistic Dihydropyridines: An Investigation of the Mechanism of Action of Nimodipine

I studied the role of calcium in the activation of isolated rings of saphenous and basilar arteries of the rabbit by comparing the effect of calcium withdrawal with the effect of the calcium antagonist nimodipine [isopropyl(2-methoxyethyl)-l,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyr- idinedicarboxylate]. Serotonin-induced contractions of both vessels were inhibited quickly by incubation in calcium-free solution, showing the contractions of both vessels to be dependent on extracellular calcium. Potassium-induced contractions of both vessels were inhibited markedly by nimodipine (basilar: ID50 = 1.7 × 10∼10 mol/liter; saphenous: ID50 = 2.6 × 10∼′° mol/liter), showing depolarization- induced calcium influx (probably through “potential sensitive channels”, PSCs) to be sensitive to nimodipine. In the basilar artery the sustained, tonic phase of serotonin-induced contractions (probably through “receptor operated chennels,” ROCs) was potently inhibited (ID50 = 7.3 × 10∼10 mol/liter) by nimodipine. However, the initial short-lived phase of this contraction of the basilar artery was relatively unaffected (IDao = 2 × 106 mol/liter), indicating that the inhibitory action of nimodipine on tonic contractions of the basilar artery was not due to antagonism at the serotonin receptor level. In contrast, in the saphenous artery the serotonin-induced contractions were unaffected by nimodipine in doses up to 2.4 × 10∼5 mol/liter. It is postulated that the selective inhibition of the sustained tonic contraction of the basilar artery is due to a selective inhibition by nimodipine of calcium movement through ROCs in this vessel. Agonist-induced activation of ROCs in peripheral blood vessels does not seem to be affected by calcium antagonists.
Simple analytic rules for model reduction and PID controller tuning

The aim of this paper is to present analytic rules for PID controller tuning that are simple and still result in good closed-loop behavior. The starting point has been the IMC-PID tuning rules that have achieved widespread industrial acceptance. The rule for the integral term has been modified to improve disturbance rejection for integrating processes. Furthermore, rather than deriving separate rules for each transfer function model, there is a just a single tuning rule for a first-order or second-order time delay model. Simple analytic rules for model reduction are presented to obtain a model in this form, including the 'half rule' for obtaining the effective time delay.
Clustering of Multidimensional Data Sets with Applications to Spatial Distributions of Ribosomal Proteins

Consider ribosomal proteins, each with a three-dimensional spatial location. Proteins related to the cofactor phenotype may be randomly or non-randomly distributed within the ribosome. To investigate this question, the Mahalanobis distance is computed between each pair of protein locations, and the optimal pairing is determined by minimizing the sum of the within-pair distances. Since no single code exists that allows for the computation of Mahalanobis distances, determining the optimal pairing, and determining whether the two groups are statistically different, we created a code that allows a user to do just this. The user can also compute an exact p-value for this distribution rather than rely on an approximation.
Introduction to Text Visualization

This book provides a systematic review of many advanced techniques to support the analysis of large collections of documents, ranging from the elementary to the profound, covering all the aspects of the visualization of text documents. Particularly, we start by introducing the fundamental concept of information visualization and visual analysis, followed by a brief survey of the field of text visualization and commonly used data models for converting document into a structured form for visualization. Then we introduce the key visualization techniques including visualizing document similarity, content, sentiments, as well as text corpus exploration system in details with concrete examples in the rest of the book.
Lifetime estimation and monitoring of power transformer considering annual load factors

This paper focuses on the realistic remaining service life prediction and monitoring system of power transformers, using an algorithm developed by the authors. The power transformer is one of the vital components of power transmission and distribution substations. It is important to know the loading capacity and remaining service life of a power transformer to ensure its economical and secure operation. This information is directly related to the condition of cellulosic insulation. According to classical method of prediction, the power transformer is considered to be operated under constant load for the remainder of its lifespan. However, in reality the load factor varies continuously, and this is a key factor affecting the service life of power transformers. In this study, a realistic method for monitoring and predicting the service lifetime of power transformers is presented by considering annual load factors. The proposed method is applicable to any power transformer and can be updated by considering relevant standards for different liquid and solid insulation materials. As a case study, life-loss calculation and the remaining service life predictions are carried out using a thermal model that has been created considering a 250 MVA mineral oil-immersed power transformer.
Eating Disorders in Men: Underdiagnosed, Undertreated, and Misunderstood

This article provides a survey of eating disorders in men, highlights the dramatic rise in eating disorders, identifies issues specific to males, and suggests areas for research and intervention. This survey concludes that men with eating disorders are currently under-diagnosed, undertreated, and misunderstood by many clinicians who encounter them. Ongoing research addressing these issues is expected to result in assessment tools and treatment interventions that will advance positive outcomes for men with eating disorders.
From “Balkanization” toward “West-Balkanization”: The Republic of Macedonia’s Euro- Atlantic prospects

This paper follows the conceptual definitions offered in Eduard Said’s “Orientalization” and Maria Todorova’s “Balkanization” toward newly coined term of “West-Balkanization”, all as essential features of constructing the Otheness. In this sense, the identities generated by colective definition by the Other (The West), are seen in the abstract symbolic values of the region, which can be traced in real social and political events. Yet, in the modern age the only political perspective for the Balkan is integration with in the West. With the new mainstream of the political and economical integration of the Balkan countries into the European Union the legal frame for mutual direct communication and collaboration is being created. The future projections for this region are movement toward integration into the European Union. So the mutual European identity project can be imposed on the region of the Balkans itself. But at the same time Europe has created a West Balkan region, which besides being a symbolic waiting room, can be seen as political ghettoization of few problematic national issues and in David Noris terms as “the last line of defense against Muslim east”. The second part of the paper is focused on the Republic of Macedonia, and its position during the last two decades. It refers to several aspects of the structural position of the country, as well as essential aspects of demography, inter-ethnic relations, regional politics and economy, all united under the Macedonia’s prospects for future Euro- Atlantic integration. The last can generate sense of political stability, but also an exclusion from negative symbolism related to historical “Balkanization” or future “West- Balkanization”.
Modified SA algorithm for wirelength minimization in VLSI circuits

In modern VLSI circuits, number of parameters viz, placement of components, dead space (un occupied space in the layout), wire length has to be minimized. The defined problems are non deterministic and NP hard optimization problem. Hence probabilistic (stochastic) methods are adopted to solve these problems. The minimization problems are multi objective optimization problems (MOO). Hence, for the convenience of computation, these MOO problems are converted into Single objective optimization (SOO) problems. It is observed from the previous research works that the bio-inspired algorithms have worked very well in the minimizing process. Evolutionary Algorithms, Genetic Algorithms, Memetic Algorithms were notable in solving the non deterministic hard problems. Moreover, Simulated annealing algorithm developed by Kirpatrick et.al, proved itself to be worthy in the minimization process. The major aim of this research work is to modify or customize the Simulated Annealing Algorithm (SAA) based on the user defined values and test it with various bench marks. This research work may be used to minimize the wire length between the blocks in complex VLSI problems. The capability of the proposed algorithm may be more efficient because of the mechanism of reducing the uphill moves made during the initial stage of the algorithm, extended search at each temperature and the improved neighborhood procedure.
An alternative inhibition method for determining cross-reactive allergens

Abstract Background: Inhibition assays are an useful tool to identify the allergen of primary sensitization of cross-reactive allergens. Classical ELISA-based inhibition assays are limited by both the availability of commercial standardized allergen extracts and the experience and knowledge needed for making home-made extracts. Moreover the direct comparison of the inhibition ELISAs outcomes between different laboratories is difficult because of different sources of used allergen extracts and a number of methodological variations. Therefore, we propose a novel ImmunoCap (Phadia, Thermofisher Scientific) based immunoinhibition method with the use of commercially available Caps as the allergen source. Methods: The novel ImmunoCap based immunoinhibition method was developed and tested with sera from patients with a well-known cross-reactive sensitization for fig (Ficus carica) and ficus (Ficus benjamina). Results were compared with a classically applied inhibition method, i.e. addition of homemade allergen extract to patient serum. Results: The amount of allergens (fig and ficus extracts) needed to reach a similar degree of inhibition was comparable for both inhibition methods. Conclusions: The ImmunoCap based inhibition assay, in addition to classical inhibition methods, is a valuable tool as the ImmunoCap analyzer and commercial allergens (Caps) are more widely available which makes the outcomes of inhibition tests comparable between different laboratories. Furthermore, in the ImmunoCap inhibition method the same protein source is used for both the inhibition of sIgE and sIgE measurement, which might be even more relevant when multiple cross-reactive allergens are tested.
Motor neuron disease on Guam: geographic and familial Occurrence, 1956–85

We investigated the geographic and familial occurrence of motor neuron disease (MND) on Guam, and then considered etiologic hypotheses related to cycad use and metal intoxication. The research was based on 303 Chamorros from Guam and 3 Chamorros from other Mariana Islands, all with MND onset on Guam during 1956–85. Inarajan and Umatac, two southern districts, each had, for both sexes combined, an average incidence rate significantly higher than the corresponding overall rate for Guam. Also, for each sex, geographic patterns of incidence were significantly related to 1)socioeconomic level (men only), 2)cycasin concentrations in cycad flour samples (men and women), 3)iron concentrations in water samples (men and women), 4)silicon concentrations in water samples (men only), and 5)cobalt and nickel concentrations in soil samples (men and women). The MND risk in susceptible sibships was about 7–28 times greater than that in the general population. The cycad hypothesis conforms somewhat better than the metal intoxication hypothesis with the data presented.
Cognitive diagnostic analysis using hierarchically structured skills

This dissertation proposes two modified cognitive diagnostic models (CDMs), the deterministic, inputs, noisy, “and” gate with hierarchy (DINA-H) model and the deterministic, inputs, noisy, “or” gate with hierarchy (DINO-H) model. Both models incorporate the hierarchical structures of the cognitive skills in the model estimation process, and can be used for situations where the attributes are ordered hierarchically. The Trends in International Mathematics and Science Study (TIMSS) 2003 data are analyzed to illustrate the proposed approaches. The simulation study evaluates the effectiveness of the proposed approaches under various conditions (e.g., various numbers of attributes, test lengths, sample sizes, and hierarchical structures). The simulation study attempts to address the model fits, items fit, and accuracy of item parameter recovery when the skills are in a specified hierarchy and varying estimation models are applied. The simulation analysis examines and compares the impacts of the misspecification of a skill hierarchy on various estimation models under their varying assumptions of dependent or independent attributes. The study is unique in incorporating a skill hierarchy with the conventional DINA and DINO models. It also reduces the number of possible latent classes and decreases the sample size requirements. The study suggests that the DINA-H/ DINO-H models, instead of the conventional DINA/ DINO models, should be considered when skills are hierarchically ordered. Its results demonstrate the proposed approaches to analyzing the hierarchically structured CDMs, illustrate the usage in applying cognitive diagnosis models to a large-scale assessment, and provide researchers and test users with practical guidelines.
Adjuvant Chemotherapy Correlates with Improved Survival after Radical Cystectomy in Patients with pT3b (Macroscopic Perivesical Tissue Invasion) Bladder Cancer

Object: To elucidate the impact of adjuvant chemotherapy (ACH) on survival in patients with urothelial carcinoma of the bladder (UCB) diagnosed with pT3 disease (perivesical tissue invasion). Methods: We reviewed the clinical data of 424 patients who underwent radical cystectomy (RC) with bilateral pelvic lymphadenectomy for UCB in our institution between 1991 and 2012. None of the patients received neoadjuvant chemotherapy. Of all patients, 101 (23.8%) were diagnosed with pT3 disease: pT3a in 43 patients and pT3b in 58 patients. The Kaplan-Meier method with the log-rank test was used to estimate and compare overall survival (OS) and cancer-specific survival (CSS) between groups. Multivariate Cox proportional hazard models were used to identify predictors of OS and CSS. Results: Five-year OS (48.5% vs. 45.6%) and CSS (56.1% vs. 56.2%) were similar in the pT3a and pT3b groups (p = 0.658 and 0.840, respectively). In all pT3 patients, ACH administration was an independent predictor for OS (p = 0.018), but not CSS (p = 0.623) on multivariate analyses. On multivariate analysis according to the pT3 sub-stage, ACH was significantly associated with improved OS (hazard ratio [HR] 0.35; 95% confidence interval [CI] 0.17-0.72, p = 0.004) and CSS (HR 0.33; 95% CI 0.10-0.85, p = 0.022) in only the pT3b group. Conclusion: Our data suggest that in pT3b disease, characterized by macroscopic perivesical tissue invasion, patients may obtain an OS benefit from the administration of ACH. Thus, our findings provide evidence for establishing appropriate indications for ACH in muscle invasive UCB.
The Amplituhedron

Perturbative scattering amplitudes in gauge theories have remarkable simplicity and hidden infinite dimensional symmetries that are completely obscured in the conventional formulation of field theory using Feynman diagrams. This suggests the existence of a new understanding for scattering amplitudes where locality and unitarity do not play a central role but are derived consequences from a different starting point. In this note we provide such an understanding for N = 4 SYM scattering amplitudes in the planar limit, which we identify as " the volume " of a new mathematical object — the Amplituhedron — generalizing the positive Grassmannian. Locality and unitarity emerge hand-in-hand from positive geometry.
Extracting rheological properties of deformable objects with Haptic vision

In this paper, we propose a novel approach to extracting rheological properties of deformable objects based on Haptic vision, which was proposed for vision-based automatic construction of virtual environment simulators. The method consists of two parts: 1) the "touch and see" part to cause deformation behavior by exerting known contact force on the object using a robot hand, and then observe how the deformed shape return to the original after contact force is removed, using a range sensor and a force-feedback sensor mounted on the robot hand, 2) the analysis and parameter extraction part from the acquired range images and force-feedback data. Experimental results using springs and wheat dough demonstrated the validity and effectiveness of the proposed approach to viscoelastic parameter extraction of rheological objects.
Very Wide Range Tunable CMOS/Bipolar Current Mirrors with Voltage Clamped Input

In low power current mode signal processing circuits it is often necessary to use current mirrors to replicate and amplify/attenuate current signals and clamp the voltage of nodes with high parasitic capacitances so that the smallest currents do not introduce unacceptable delays. The use of tunable active-input current mirrors would meet both requirements. In conventional active-input current mirrors, stability compensation is required. Furthermore, once stabilized, the input current cannot be made arbitrarily small. In this paper we introduce two new active-input current mirrors that clamp their input node to a given voltage. One of them does not require compensation, while the other may under some circumstances. However, for both, the input current may take any value. The mirrors can operate with their transistors biased in strong inversion, weak inversion, or even as CMOS compatible lateral bipolar devices. If it is biased in weak inversion or as lateral bipolars, the current mirror gain can be tuned over a very wide range. According to the experimental measurements provided in this paper, the input current may spawn beyond nine decades and the current mirror gain can be tuned over 11 decades. As an application example, a sinusoidal g/sub m/-C-based VCO has been fabricated, whose oscillation frequency could be tuned for over seven decades, between 73 mHz and 1 MHz.
Using 3D hand gestures and touch input for wearable AR interaction

While wearable devices have been developed that incorporate computing, sensing and display technology into a head-worn package, they often have limited input methods that might not be appropriate for natural 3D interaction which is necessary for Augmented Reality (AR) applications. In this paper we report on a prototype interface that supports natural 3D free-hand gestures on wearable computers. In addition to using hand gestures for AR interaction, we also look into allowing users to combine low resolution hand gestures in 3D with high resolution touch input. We show how this could be used in a wearable AR interface and present early pilot study results.