Miracle-dz/UniFAR-FTUs huggingface dataset:
Caracteriza\c{c}\~ao de circuitos pecu\'arios com base em redes de movimenta\c{c}\~ao de animais

GRISI-FILHO, J. H. H. Characterization of production zones based on animal movement networks. [Caracterização de circuitos pecuários com base em redes de movimentação de animais. ] 2012. 46 f. Tese (Doutorado em Ciências) Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, 2012. A network is a set of nodes that are linked together by a set of edges. Networks can represent any set of objects that have relations among themselves. Communities are sets of nodes that are related in an important way, probably sharing common properties and/or playing similar roles within a network. When network analysis is applied to study the livestock movement patterns, the epidemiological units of interest (farm premises, counties, states, countries, etc.) are represented as nodes, and animal movements between the nodes are represented as the edges of a network. Unraveling a network structure, and hence the trade preferences and pathways, could be very useful to a researcher or a decision-maker. We implemented a community detection algorithm to find livestock communities that is consistent with the definition of a livestock production zone, assuming that a community is a group of farm premises in which an animal is more likely to stay during its life time than expected by chance. We applied this algorithm to the network of within animal movements made inside the State of Mato Grosso, for the year of 2007. This database holds information about 87,899 premises and 521,431 movements throughout the year, totalizing 15,844,779 animals moved. The community detection algorithm achieved a network partition that shows a clear geographical and commercial pattern, two crucial features to preventive veterinary medicine applications, and also has a meaningful interpretation in trade networks where links emerge from the choice of trader nodes.
SMALL AGGREGATIONS OF ON / OFF TRAFFIC SOURCES

A simple and effective technique for synthesis of network traffic is evaluated, both in simulation and in a real network testbed. The technique, aggregation of a small number of on/off sources with heavy-tailed state holding times is seen to provide traffic that has characteristics consistent with long-range dependence and offers a convenient method for fitting mean, variance, and Hurst parameter of target workloads.
Prognostic significance of Jab1 expression in laryngeal squamous cell carcinomas.

PURPOSE Jun activation domain-binding protein 1 (Jab1) is known as a coactivator of AP1 transcription factor, which contributes to tumor progression by degrading the p27kip1 protein. The purpose of this study is to investigate whether Jab1 expression is correlated with p27kip1 level and cell proliferation, as well as whether Jab1 expression is associated with clinicopathologic variables and prognosis of laryngeal squamous cell carcinoma (LSCC). EXPERIMENTAL DESIGN Immunohistochemical and/or Western blot analysis was done in HEp-2 cells and 102 cases of LSCCs. RESULTS Jab1 expression was negatively associated with p27kip1 expression and was positively associated with cell proliferation both in HEp-2 cells and LSCCs. Jab1 overexpression was detected in 51% LSCCs and was significantly associated with unfavorable clinicopathologic variables. Survival analysis revealed that Jab1 overexpression is significantly associated with short disease-free and overall survival (P = 0.0036 and P = 0.0001, respectively). When Jab1 and p27kip1 are combined, patients with Jab1(+)/p27kip1(-) revealed poor disease-free and overall survival (P= 0.0008 and P < 0.0001, respectively). When Jab1 expression and lymph node status are combined, patients with Jab1(+)/lymph node(+) revealed poorer disease-free andoverall survival than others (P < 0.0001 and P < 0.0001, respectively). Furthermore, patients with the phenotype of Jab1(+)/p27kip1(-)/lymph node(+) revealed the worst disease-free and overall survival (P < 0.0001 and P < 0.0001, respectively). Multivariate analysis revealed that Jab1 protein is an independent prognostic indicator for overall survival. CONCLUSIONS These findings suggested that Jab1 protein may contribute to the tumor progression and represent a novel prognostic indicator for LSCCs.
Local differentiability and monotonicity properties of Voronoi diagrams for disjoint convex sites in three dimensions

This paper studies local properties of Voronoi diagrams of sets of disjoint compact convex sites in R. It is established that bisectors are C surfaces and trisectors are C curves, and that as a point moves along a trisector its clearance sphere develops monotonically (Lemma 2.4). This monotonicity property is useful in establishing the existence of Voronoi vertices bounding edges in certain situations.1 The paper then considers the diagram for a set of disjoint spheres. Considerations about general position are covered in detail. By letting the spheres grow from point sites till they reach their true radius, it is shown that the Voronoi cell for the smallest site has complexity O(n), assuming that the sites are of at most k distinct radii. It follows that the Voronoi diagram is O(n). Although this is weaker than Aurenhammer’s result [1] establishing O(n) complexity with no restriction on radius, the techniques may be of value for studying more general Voronoi diagrams. Finally, the paper shows that without the bound on the number of different radii, the cell owned by a point site can have complexity Ω(n). 1 Voronoi diagrams: differentiability properties This paper considers the Voronoi diagrams of spherical sites in R. For a general survey of Voronoi diagrams see [2]. The current state of knowledge about the complexity of Voronoi diagrams, in 3 dimensions, is scanty. e-mail: odunlain@maths.tcd.ie. Mathematics department website: http://www.maths.tcd.ie. Some of this work was presented at the eighteenth European Conference on Computational Geometry, Bonn, Germany, April 2003. 1 Chee Yap [8] seems to have been first to exploit such monotonicity properties.
A Connectionist Formulation of Learning in Dynamic Decision-Making Tasks

A formulation of learning in dynamic decision-making tasks is developed, building on the application of control theory to the study of human performance in dynamic decision making and a connectionist approach to motor control. The formulation is implemented as a connectionist model and compared with human subjects in learning a simulated dynamic decision-making task. When the model is pretrained with the prior knowledge that subjects are hypothesized to bring to the task, the model’s performance is broadly similar to that of subjects. Furthermore, individual runs of the model show variability in learning much like individual subjects. Finally, the effects of various manipulations of the task representation on model performance are used to generate predictions for future empirical work. In this way, the model provides a platform for developing hypotheses on how to facilitate learning in dynamic decision-making tasks.
A Novel Magnetic Resonance Imaging Classification of Discoid Lateral Meniscus Based on Peripheral Attachment

Background In the symptomatic discoid lateral meniscus, the effectiveness of preoperative magnetic resonance imaging (MRI) is not well documented. Hypothesis Magnetic resonance imaging classification will provide more information to the surgeon in choosing the appropriate treatment methods with the help of arthroscopic findings. Study design Cohort study (diagnosis); Level of evidence, 2. Methods Sixty-seven patients (82 knees) were reviewed. The preoperative MRI was checked in 76 of 82 knees. The Lysholm and Ikeuchi grading scales were evaluated. Images were analyzed from MRI, and findings were classified into 4 categories: no shift, anterocentral shift, posterocentral shift, and central shift. Tear pattern classifications were based on arthroscopic findings: horizontal tear, peripheral tear, horizontal and peripheral tear, posterolateral corner loss, and others. The correlations between MRI classification tear patterns and surgical methods were analyzed using the chi-square test or the Fisher exact test. The sensitivity, specificity, and accuracy of shift in preoperative MRI–according to the existence of peripheral tear when corroborated with arthroscopy–were also analyzed with the chi-square test. Inter- and intraobserver reliability was statistically analyzed by producing the inter- and intraclass correlation coefficient. Results The mean preoperative Lysholm score was 77.3 (range, 43-97), and the last follow-up Lysholm score had increased to 96.8 (range, 84-100; P <. 001). At last follow-up (100% follow-up), the Ikeuchi grading scale scored 48 knees as excellent, 30 as good, and 4 as fair. According to the MRI classification, 43 knees were no shift; 6, anterocentral shift; 15, posterocentral shift; and 12, central shift. Shift-type knees had a significantly larger number of peripheral tears, and repairs were performed in the shift-type knees (55%) more frequently than in the no-shift-type knees (28%). Among 82 knees, 31 were repaired simultaneously after a central partial meniscectomy. Conclusion Magnetic resonance imaging classification provides more information to surgeons in choosing the appropriate treatment methods, although the final decision regarding procedure is made during arthroscopy after thorough analysis of the tear.
Hantavirus pulmonary syndrome in Brasilia periphery: a diagnostic challenge.

BACKGROUND Hantavirus pulmonary syndrome (HPS) is an emerging rodent-borne disease in the American continent, characterized by acute respiratory distress and a high case-fatality ratio. The present work describes a case of HPS, with favorable outcome, whose initial features were mistaken for leptospirosis or other less severe acute infections. METHODOLOGY The case of a 32-year-old male with an uneventful course of HPS is reported. He was inadvertently infected at work by exposure to a rodent-contaminated environment in Brasília, Federal District vicinity, during May 2008. RESULTS AND CONCLUSIONS Fever, headache and myalgia after exposure to a rodent-contaminated environment raised clinical suspicion. Non-cardiac pulmonary edema, hydrothorax, neutrophilia with band forms 26%, high hematocrit, thrombocytopenia, and elevated liver enzymes were observed. Leptospirosis and dengue were the main differential diagnoses because both pathogens are endemic in the area. Hantavirus IgM antibody-capture ELISA was positive, while tests for dengue, leptospirosis and yellow fever were negative. The prognosis for HPS is ominous and misdiagnoses may increase mortality. Better chances of survival depend on prompt intensive care support. Reports of moderate or less typical cases can raise the suspicion index among primary care and hospital-based physicians about this uncommon but severe condition that often affects previously healthy young individuals from developing countries, and subjects who interact with rodent-infested environments in North America. High awareness of HPS allowed successful management of the patient, even before establishing the diagnosis, by serological tests at the reference laboratory of the Ministry of Health. Clinical suspicion favored warning local health authorities about a new case of HPS.
Evaluation of collisions between polygonal models in virtual assembly

Collisions between polygonal models may not reflect collisions between real objects in reality because of polygonal approximation and designed tolerance. This problem reduces the reliability of simulation in virtual assembly and sometimes even results in wrong conclusions. To solve the problem, we propose a novel collision evaluation algorithm based on generalized penetration depth, approximation information and tolerance information. Given two interfered polygonal models, generalized penetration depth is calculated using relative motion information. Then two thresholds, which are based on approximation information and tolerance information, are integrated to evaluate collisions between polygonal models. In order to distinguish the status of collisions for furfure analysis, the collisions between polygonal models are categorized into three types by evaluation algorithm, namely real collision, potential collision and fake collision. Computational efficiency and accuracy of the evaluation algorithm are verified in virtual assembly.
Cytokinin Signaling Activates WUSCHEL Expression during Axillary Meristem Initiation[OPEN]

Cytokinin signaling, in combination with epigenetic regulation, de novo activates WUSCHEL expression during axillary meristem initiation to enable shoot branching. The homeodomain transcription factor WUSCHEL (WUS) defines the shoot stem cell niche, but the mechanisms underlying the establishment of WUS expression remain unclear. Here, we show that cytokinin signaling precedes WUS expression in leaf axils and activates WUS expression de novo in the leaf axil to promote axillary meristem initiation. Furthermore, type-B Arabidopsis response regulator proteins, which are transcriptional activators in the cytokinin signaling pathway, directly bind to the WUS promoter and activate its expression. Finally, we show that cytokinin activation of WUS in the leaf axil correlates with increased histone acetylation and methylation markers associated with transcriptional activation, supporting the fact that WUS expression requires a permissive epigenetic environment to restrict it to highly defined meristematic tissues. Taken together, these findings explain how cytokinin regulates axillary meristem initiation and establish a mechanistic framework for the postembryonic establishment of the shoot stem cell niche.
The guanine-quadruplex aptamer 93del inhibits HIV-1 replication ex vivo by interfering with viral entry, reverse transcription and integration

Background We have previously identified the guaninerich oligonucleotide (ODN) 93del as a potent inhibitor in vitro of HIV-1 integrase. Moreover, low nanomolar concentrations of ODN 93del have been shown to inhibit HIV-1 replication in infected cells. Methods To investigate the ex vivo mechanism of ODN 93del inhibition, we analysed its antiviral effects on the early steps of HIV-1 replication such as viral entry, reverse transcription and integration using quantitative PCR. Results In addition to the effect on viral entry previously described for other guanine-quadruplex ODNs, transfection experiments showed that ODN 93del severely affects the proviral integration step independently of the effect on viral entry. Moreover, incubation of viral particles with ODN 93del revealed a potential microbicide activity of the aptamer. Conclusions Our data point to an original multimodal inhibition of HIV-1 replication by ODN 93del, strongly suggesting that targets of guanine-quartet-forming ODNs involve entry as well as other intracellular early steps of HIV-1 replication.
Consumer response to corporate social responsibility initiatives: an investigation of two necessary awareness states

Consumers increasingly expect companies to make a broader contribution to society. The business benefits of doing so, however, are currently not evident. Prior studies conclude that consumers’ purchase decisions are positively influenced by socially responsible initiatives. However, this insight appears to be of little practical relevance if the level of awareness of such initiatives among consumers is very low. McWilliams and Siegel (2001) emphasise that if CSR is to act as a point of differentiation, awareness of a firm’s CSR activities is crucial. We empirically test this awareness level. In doing so we respond to Maignan’s (2001) call for research to determine the extent to which consumers are aware of CSR activities businesses engage in. We also determine the extent to which consumers are aware of the social issues firms engage with their CSR programs, a critical antecedent to making sense of firms' CSR-related claims. Disciplines Business | Social and Behavioral Sciences Publication Details This conference paper originally published as Dolnicar S & Pomering A, Consumer response to corporate social responsibility initiatives: an investigation of two necessary awareness states, In M. Thyne, K. R. Deans & J. Gnoth (Eds.), Proceedings of the Australian and New Zealand Marketing Academy Conference (pp. 2825-2831). 3-6 December 2007. Dunedin, New Zealand: Australian and New Zealand Marketing Academy. This conference paper is available at Research Online: http://ro.uow. edu.au/commpapers/422 Consumer response to corporate social responsibility initiatives: An investigation of two necessary awareness states Sara Dolnicar, Alan Pomering, University of Wollongong, Australia
Content Extraction from HTML Documents

In recent times, the way people access information from the web has undergone a transformation. The demand for information to be accessible from anywhere, anytime, has resulted in the introduction of Personal Digital Assistants (PDAs) and cellular phones that are able to browse the web and can be used to find information using wireless connections. However, the small display form factor of these portable devices greatly diminishes the rate at which these sites can be browsed. This shows the requirement of efficient algorithms to extract the content of web pages and build a faithful reproduction of the original pages with the important content intact.
Persistence of Bovine Viral Diarrhea Virus Is Determined by a Cellular Cofactor of a Viral Autoprotease

ABSTRACT Polyprotein processing control is a crucial step in the life cycle of positive-strand RNA viruses. Recently, a vital autoprotease generating an essential viral replication factor was identified in such a virus, namely, the pestivirus bovine viral diarrhea virus. Surprisingly, the activity of this protease, which resides in nonstructural protein 2 (NS2), diminishes early after infection, resulting in the limitation of viral RNA replication. Here, we describe that a cellular chaperone termed Jiv (J-domain protein interacting with viral protein) acts as a cofactor of the NS2 protease. Consumption of the intracellular Jiv pool is responsible for temporal regulation of protease activity: overexpression of Jiv interfered with regulation and correlated with increased accumulation of viral RNA; downregulation of the cellular Jiv level accelerated the decline of protease activity and reduced intracellular viral RNA levels and virion production. Accordingly, the amount of a cellular protein controls pestiviral replication by limiting the generation of active viral protease molecules and replication complexes. Importantly, this unique mechanism of replication control is essential for maintenance of the noncytopathogenic phenotype of the virus and thereby for its ability to establish persistent infections. These results add an entirely novel aspect to the understanding of the molecular basis of viral persistence.
TUW @ TREC Clinical Decision Support Track

Abstract : This document describes the participation of Vienna University of Technology in the TREC Clinical Decision Support Track 2014. Four different search models are investigated, as well as different strategies to index the corpus and to extract the most relevant information from the topics. Our results conclude that BM25 and Vector Space Model had similar performance for P@10 and inferred NDCG.
Graphical State Space Programming: A visual programming paradigm for robot task specification

We describe a framework that combines a software development paradigm, a software visualization technique, and a tool for robot programming. This infrastructure is called “Graphical State Space Programming” (GSSP), and allows robot application programs to be decomposed and visualized within state-dependent views. Our approach simplifies and expedites the programming process for robot routines and behaviors, and we examine the performance improvement that ensues through a set of controlled user studies. The usability and effectiveness of GSSP are also illustrated using a field demonstration with an aerial robotic vehicle.
Conflit visuo-tactilo-kinesthsique et activit sensorimotrice manuelle

Resume ; Un conflit visuo-tactilo-kinesthesique a ete presente a des sujets de 6-8 ans au cours (experience I) ou apres (experience II) la realisation reussie d'une tâche sensorimotrice manuelle impliquant une evaluation tactile correcte de la propriete conflictuelle (la taille de l'objet). Ces etudes cherchaient a savoir si le fait que le toucher a un role important dans le controle moteur des mouvements de saisie et manipulation, modifie les relations habituelles de dominance qu'entretiennent la vision et le toucher. Les resultats montrent que les sujets soumis au conflit donnent generalement des reponses de compromis, ce qui atteste de la persistance du biais introduit par les donnees visuelles discordantes. Dans l'experience III, la resistance du toucher au conflit est mesuree apres une prise de connaissance des stimuli par une activite sensorimotrice d'encastrement, apres une exploration perceptive manuelle libre et apres une exploration perceptive limitee a l'index d'une main. Sans conflit, la premiere condition donne les meilleures performances, et la troisieme les moins bonnes. Mais des que des donnees visuelles discordantes sont introduites, les trois groupes manifestent les memes comportements de compromis. Ces observations sont discutees en fonction des relations pouvant exister entre les mecanismes impliques dans le controle tactile de la motricite manuelle et ceux qui reglent l'unite visuo-tactile a un niveau perceptif de type declaratif. ; Mots cles : perception tactile, conflit perceptif, controle sensoriel du mouvement.
Duration modeling and memory optimization in a Mandarin TTS system

Current speech synthesis efforts, both in research and in applications, are dominated by methods based on concatenation of spoken units. New progress in the concatenative text-to-speech (TTS) technology can be made mainly from two directions, either by reducing the memory footprint to integrate the system into embedded system, or by improving the synthesized speech quality in terms of intelligibility and naturalness. In this paper, we are focusing on the memory footprint reduction in a Mandarin TTS system. We show that significant memory reductions can be achieved through duration modeling and memory optimization of the lexicon data. The results obtained in the experiments indicate that the memory requirements of the duration data and lexicon can be significantly reduced while keeping the speech quality unaffected. For practical embedded implementations, this is a significant step towards an efficient TTS engine implementation. The applicability of the approach is verified in the speech synthesis system.
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.

Lipid homeostasis in vertebrate cells is regulated by a family of membrane-bound transcription factors designated sterol regulatory element–binding proteins (SREBPs). SREBPs directly activate the expression of more than 30 genes dedicated to the synthesis and uptake of cholesterol, fatty acids, triglycerides, and phospholipids, as well as the NADPH cofactor required to synthesize these molecules (1–4). In the liver, three SREBPs regulate the production of lipids for export into the plasma as lipoproteins and into the bile as micelles. The complex, interdigitated roles of these three SREBPs have been dissected through the study of ten different lines of gene-manipulated mice. These studies form the subject of this review.