Miracle-dz/UniFAR-FTUs huggingface dataset:
Simulating Organizational Life: Self-Directed Teams in the Classroom.

During the past decade, many American companies have shifted their work styles from classically controlling management styles to self-motivating teams. For this reason, a few communication educators are now exploring alternative models of teaching. If students have the opportunity to experience many of the concepts covered in organizational communication, they will be more likely to remember the information when faced with the same phenomena in the business world. By structuring an organizational communication course around the concept of self-directed teams, students take responsibility for their work and communication, improve their performance, and experience many of the facets of organizational communication. Collaborative or cooperative techniques help students get a better understanding of work in the "real world. " In a model, created by both a professor and students, organizational life was simulated for the classroom. Decisions regarding texts, general content, and loosely structured assignments were made by the professor with room for student input. Teams implemented their own rules which were appropriate for members, and the shape of assignments was decided by the class. Student ideas permeated the course content. In their final evaluations, students reported having a positive experience. Probably the most glaring weakness of this model was lack of student motivation, perhaps due to the lack of identification of a concrete shared goal. (Contains 12 references.) (CR) ******************************************************************************** * Reproductions supplied by EDRS are the best that can be made * * from the original document. * ******************************************************************************** Simulating Organizational Life, 1 Simulating Organizational Life: Self-Directed Teams in the Classroom
Multiservice allocation for multiaccess wireless systems

This paper discusses principles for allocating multiple bearer services onto different subsystems in multiaccess wireless systems. Based on the included subsystem's multiservice capacities, under certain constraints near-optimum subsystem service allocations that maximize combined multiservice capacity are derived through simple optimization procedures. These favorable service allocations are either extreme points where services, as far as possible, are allocated to the subsystems best at supporting them, or they are characterized by the relative efficiency of supporting services being equal in all subsystems. The consequences of this include that services should typically be mixed in subsystems with convex capacity regions and isolated in subsystems with concave capacity regions. Simple user assignment algorithms based on this are also discussed. Additionally, illustrating the main findings of the analysis, some system examples are given, including a case study with combined global system for mobile communications (GSM) and wideband code-division multiple-access (WCDMA) systems. The gain of using the proposed service allocation principles compared to a reference case of maintaining equal service mixes in all subsystems depends on the shape of the subsystem capacity regions; the more different the capacity regions, the larger the gain. In the GSM and WCDMA case study, capacity gains of up to 100% in terms of supported data users for a fixed voice traffic load are achieved.
Playing MMORPGs: Connections between Addiction and Identifying with a Character

Addiction to online role-playing games is one of the most discussed aspects of recent cyberpsychology, mainly for its potentially negative impact on the social lives of young people. In our study, we focus on some aspects of youth and adolescent addiction to MMORPGs. We investigated connections between players and their game characters and examined if, and in what ways, player relationship to their character affected potential addiction. Players attitude to their characters seems to play a specific role, since players who tend to be addicted view their characters as being superior and more often wish to be like their characters in their real lives. Our research also confirmed that younger players are generally more prone to addiction.
SlimPLS: A Method for Feature Selection in Gene Expression-Based Disease Classification

A major challenge in biomedical studies in recent years has been the classification of gene expression profiles into categories, such as cases and controls. This is done by first training a classifier by using a labeled training set containing labeled samples from the two populations, and then using that classifier to predict the labels of new samples. Such predictions have recently been shown to improve the diagnosis and treatment selection practices for several diseases. This procedure is complicated, however, by the high dimensionality if the data. While microarrays can measure the levels of thousands of genes per sample, case-control microarray studies usually involve no more than several dozen samples. Standard classifiers do not work well in these situations where the number of features (gene expression levels measured in these microarrays) far exceeds the number of samples. Selecting only the features that are most relevant for discriminating between the two categories can help construct better classifiers, in terms of both accuracy and efficiency. In this work we developed a novel method for multivariate feature selection based on the Partial Least Squares algorithm. We compared the method's variants with common feature selection techniques across a large number of real case-control datasets, using several classifiers. We demonstrate the advantages of the method and the preferable combinations of classifier and feature selection technique.
A proximal-Newton method for unconstrained convex optimization in Hilbert spaces

Abstract We propose and study the iteration-complexity of a proximal-Newton method for finding approximate solutions of the problem of minimizing a twice continuously differentiable convex function on a (possibly infinite dimensional) Hilbert space. We prove global convergence rates for obtaining approximate solutions in terms of function/gradient values. Our main results follow from an iteration-complexity study of an (large-step) inexact proximal point method for solving convex minimization problems.
Relationship Between Connexin Expression and Gap–Junction Resistivity in Human Atrial Myocardium

Background—The relative roles of the gap-junctional proteins connexin40 (Cx40) and connexin43 (Cx43) in determining human atrial myocardial resistivity is unknown. In addressing the hypothesis that changing relative expression of Cx40 and Cx43 underlies an increase in human atrial myocardial resistivity with age, this relationship was investigated by direct ex vivo measurement of gap-junctional resistivity and quantitative connexin immunoblotting and immunohistochemistry. Methods and Results—Oil-gap impedance measurements were performed to determine resistivity of the intracellular pathway (Ri), which correlated with total Cx40 quantification by Western blotting (rs=0.64, P<0.01, n=20). Specific gap-junctional resistivity (Rj) correlated not only with Western immunoquantification of Cx40 (rs=0.63, P=0.01, n=20), but also more specifically, with the Cx40 fraction localized to the intercalated disks on immunohistochemical quantification (rs=0.66, P=0.02, n=12). Although Cx43 expression showed no correlation with resistivity values, the proportional expression of the 2 connexins, (Cx40/[Cx40+Cx43]) correlated with Ri and Rj (rs=0.58, P<0.01 for Ri and rs=0.51, P=0.02 for Rj). Advancing age was associated with a rise in Ri (rs=0.77, P<0.0001), Rj (rs=0.65, P<0.001, n=23), Cx40 quantity (rs=0.54, P=0.01, n=20), and Cx40 gap–junction protein per unit area of en face disk (rs=0.61, P=0.02, n=12). Conclusions—Cx40 is associated with human right atrial gap-junctional resistivity such that increased total, gap-junctional, and proportional Cx40 expression increases gap-junctional resistivity. Accordingly, advancing age is associated with an increase in Cx40 expression and a corresponding increase in gap-junctional resistivity. These findings are the first to demonstrate this relationship and a mechanistic explanation for changing atrial conduction and age-related arrhythmic tendency.
Optimizing wait-states in the synthesis of memory references with unpredictable latencies

In here we consider the problem of automatic synthesizing, from C to Verilog, circuits that are optimized to handle unpredictable latencies of memory operations. Unpredictable memory latencies can occur due to the use of on chip caches, DRAM memory modules, buffers/queues or multi-port memories. Typically highlevel synthesis compilers assume fixed and known memory latencies thus the technique presented here expands the use of HLS. Assume that in a current state we have k active memory references that can terminate in this clock cycle or possibly continue for an unknown number of clock cycles. Thus, the scheduler must emit 2k new states, one state for each possible combination of memory requests that can continue in the next clock cycle. Synthesizing a state machine with exponential number of states is not practical thus we show a simple technique of synthesizing a compact state machine which is a compromise between the fast full exponential state machine and the linear state machine that would have been generated had we waited for the termination of all the active memory references in every state. Our results shows that the compact state machine obtains similar performances as the full state machine but with a significant less number of resources.1
Beta2‐adrenergic receptor signaling in CD4+ Foxp3+ regulatory T cells enhances their suppressive function in a PKA‐dependent manner

Beta2‐adrenergic receptor (B2AR) signaling is known to impair Th1‐cell differentiation and function in a cAMP‐dependent way, leading to inhibition of cell proliferation and decreased production of IL‐2 and IFN‐γ. CD4+ Foxp3+ Treg cells play a key role in the regulation of immune responses and are essential for maintenance of self‐tolerance. Nevertheless, very little is known about adrenergic receptor expression in Treg cells or the influence of noradrenaline on their function. Here we show that Foxp3+ Treg cells express functional B2AR. B2AR activation in Treg cells leads to increased intracellular cAMP levels and to protein kinase A (PKA)‐dependent CREB phosphorylation. We also found that signaling via B2AR enhances the in vitro suppressive activity of Treg cells. B2AR‐mediated increase in Treg‐cell suppressive function was associated with decreased IL‐2 mRNA levels in responder CD4+ T cells and improved Treg‐cell‐induced conversion of CD4+ Foxp3− cells into Foxp3+ induced Treg cells. Moreover, B2AR signaling increased CTLA‐4 expression in Treg cells in a PKA‐dependent way. Finally, we found that PKA inhibition totally prevented the B2AR‐mediated increase in Treg‐cell suppressive function. Our data suggest that sympathetic fibers are able to regulate Treg‐cell suppressive activity in a positive manner through B2AR signaling.
How have Software Engineering Researchers been Measuring Software Productivity? - A Systematic Mapping Study

Context: productivity has been a recurring topic, and despite its importance, researchers have not yet reached a consensus on how to properly measure productivity in software engineering. Aim: to investigate and better understand how software productivity researchers are using software productivity metrics. Method: we performed a systematic mapping study on publications regarding software productivity, extracting how software engineering researchers are measuring software productivity. Results: In total, 91 software productivity metrics were extracted. The obtained results show that researchers apply these productivity metrics mainly focusing on software projects and developers, and these productivity metrics are predominantly composed by Lines of Code (LOC), Time and Effort measures. Conclusion: although there is no consensus, our results shows that single ratio metrics, such as LOC/Effort, for software projects, and LOC/Time, for software developers, are a tendency adopted by researchers to measure productivity.
Multilinear Discriminant Analysis With Subspace Constraints for Single-Trial Classification of Event-Related Potentials

The classification accuracy of a brain-computer interface (BCI) frequently suffers from ill-posed and overfitting problems. To avoid and alleviate these problems, we propose a method of a multilinear discriminant analysis with constraints to augment parameter reduction, regularization, and additional prior information for event-related potential (ERP)-based BCIs. The method reduces the number of parameters by multilinearization, regularizes the ill-posedness via subspaces that constrain the parameter spaces, and incorporates a brain functional connectivity through the constraints. The experimental results show that the proposed method improved the classification accuracy rates in a single-trial ERP processing.
Indian Music Instruments Semantic Knowledge Representation

Web is an intelligent incarnation and advancement in World Wide Web to store, annotate, index and retrieve information by providing knowledge representation, classification, and categorization, a common understanding among the group of people and structuring the information in machine processable format. To structure the information in machine processable semantic models Semantic Web have introduced the concept of ontology. Ontologies are most widely used in artificial intelligence, semantic web, software engineering, information retrieval, knowledge representation, knowledge sharing, knowledge integration, knowledge reuse, and so on. Music plays a vital role in human life. A vast number of musical instruments are used to produce rhythmic sounds. The rapid growth of technology enables on line music. The instruments used and the terms used to describe the concepts varies from individual groups. To support concept based knowledge representation and semantic retrieval music files music instruments knowledge should be identified and represented. This raises the need for construction of Indian music instruments ontology. This ropes semantic web with more intelligent, capable, relevant, responsive interaction and high performance retrieval system. The Indian music instrument ontology is been constructed and the paper concludes with conclusion and future work. KeywordsInstruemtns, Ontology, Semantic Web
Dissemination of Electronic Patient Records Using Primary Care Referrals as a Vector for Change

The Online Medical Record (OMR) is a full-featured shared electronic patient record in use since 1989 at Beth Israel Deaconess Medical Center in Boston. The first practice to use the OMR was a primary care practice. We observed the pattern of voluntary adoption of the OMR and the referral patterns from primary care to specialists. Adoption of the OMR among specialists has accelerated in recent years, in many cases mirroring the referral patterns from primary care to specialists. We hypothesize that referral of patients from primary care providers to specialists exposes these specialists to the benefits the electronic patient record and may promote the use of this technology. We conclude that these referral patterns provide a vector for the dissemination of electronic patient records. The important lesson is that EPR implementation in a health care network should begin with primary care to ensure the most efficient diffusion of this technology throughout the enterprise.
MicroRNA‐195‐5p suppresses osteosarcoma cell proliferation and invasion by suppressing naked cuticle homolog 1

MiR‐195‐5p has been shown to play an essential role in human cancer progression. Nevertheless, the biological role of miR‐195‐5p in osteosarcoma development remains unclear. In this study, real‐time PCR was performed to examine the miR‐195‐5p expression in human osteosarcoma cell lines. CCK‐8 assay and Transwell assay were carried out to measure the effect of miR‐195‐5p on cell proliferation and invasion. Luciferase reporter assay was used to identify the targets of miR‐195‐5p. The results showed that miR‐195‐5p was significantly downregulated in osteosarcoma cells. Forced expression of miR‐195‐5p significantly inhibited cell proliferation, suppressed cell migration and invasion, compared with wild‐type and control‐transfected osteosarcoma cells. Luciferase reporter assay revealed that miR‐195‐5p binds to the 3′‐untranslated region (UTR) of Naked cuticle homolog 1 (NKD1), indicating that NKD1 was a novel target of miR‐195‐5p. NKD1 mRNA and protein levels were reduced after overexpression of miR‐195‐5p. Moreover, silencing of NKD1 significantly inhibited the proliferation and invasion of osteosarcoma cells. Accordingly, our results support a tumor suppressor role of miR‐195‐5p in osteosarcoma through inhibiting NKD1, and it may be a promising therapeutic target for osteosarcoma.
Torsional properties of new and used rotary K3 NiTi files.

The purpose of this study was to compare torque (gcm) and angle of rotation (degrees) at fracture of new and used NiTi K3 . 04 rotary instruments. The relation between size of instrument and torque at fracture was also investigated. The torque and angle of rotation at fracture of new and used NiTi K3 . 04 rotary instruments sizes 15 to 40 were determined according to ANSI/ADA Specification No. 28. Analysis of variance was used to compare the torque and angle of rotation at fracture among the different sizes of the new instruments and between new and used instruments of the same size (alpha = 0.05). The relationship between torque at fracture and size of instrument was determined with a regression analysis. Torque at fracture of the new instruments increased significantly with the diameter (p < 0.05). The used instruments, sizes 25 to 40, had significantly lower torque at fracture values compared to the new ones (p < 0.05). The used instruments, sizes 20 and 35 had significantly lower angle of rotation at fracture compared to the new ones (p < 0.05). A stronger relationship was found between the size of the file and the torque at fracture for the new instruments (p < 0.0001) compared to the used ones (p < 0.0001). The results of the present study suggested that the torque at fracture values of new instruments increased significantly with the diameter. The results also suggested that repeated use of . 04 K3 instruments affected mainly the torque at fracture.
Tuberculosis in Hematopoietic Stem Cell Transplant Recipients

Literature on tuberculosis (TB) occurring in recipients of Hematopoietic Stem Cell Transplant (HSCT) is scanty even in countries where TB is common. Most reports of TB in HSCT patients were from ASIA, in fact the TB incidence ranging from 0.0014 (USA) to 16% (Pakistan). There are few reports of TB diagnosis during the first two weeks after HSCT; most of cases described in the literature occurred after 90 days of HSCT, and the lung was the organ most involved. The mortality ranged from 0 to 50% and is higher in allogeneic HSCT than in autologous. There is no consensus regarding the screening with tuberculin skin test or QuantiFERON-TB gold, primary prophylaxis for latent TB, and whether the epidemiologic query should be emphasized in developing countries with high prevalence of TB.
Risk factors of suicidal behavior in alcohol-dependent individuals

The problem of suicidal behavior related to psychiatric disorders has been investigated in numerous studies. As well known, patients with affective disorders are the group with the highest risk of suicide. Nevertheless, there is some research studies suggesting that alcohol dependence may increase risk of suicide, even larger than depression. Thus, investigating risk factors of suicide among alcoholics has become very important. There are several areas, which have been indicated as essential for risk of suicide in alcohol dependence, including demographic, psychopathological, psychological, social, family, biological, and genetic factors as well as health-related, or history of abuse and its treatment. In the paper, current research studies on risk factors of suicide behavior in alcohol dependence are reviewed. Psychiatry 2011; 8, 1: 7–17 key words: suicide, alcohol dependence, risk factors, genetics, serotonin system Wstęp Według danych World Health Organization (WHO) około 900 tysięcy osób rocznie na całym świecie popełnia samobójstwo [1]. Szacuje się, że częstość prób samobójczych jest 10–20 razy większa [2]. Z informacji opublikowanych przez Komendę Główną Policji (KGP) wynika, że w 2009 roku samobójstwo popełniły w Polsce 4384 osoby: 3739 mężczyzn i 645 kobiet; była to liczba wyższa niż przez 3 poprzedzające lata. Do 2008 roku można było obserwować, przebiegający z wahaniami, powolny spadek liczby samobójstw w Polsce. Najwyższą liczbę zgonów samobójczych w ostatnim 20-leciu (5569) odnotowano w 1993 roku. Wśród 5913 osób, które podjęły próby samobójcze odnotowane w 2009 roku przez policję, u ponad 4200 osób metodą odebrania sobie życia było powieszenie. Najliczniejszą grupę wiekową stanowiły osoby w wieku 50–54 lat (721 osób). Nie określono precyzyjnie liczby osób, które były pod wpływem alkoholu w chwili śmierci. Z danych KGP wynika jedynie, że wśród tych, które podjęły próbę samobójczą, 1453 spożywało wcześniej alkohol, 44 osoby były pod wpływem substancji psychotropowych (leków lub środków uzależniających), a u 668 nie stwierdzono obecności jakichkolwiek substancji psychoaktywnych. Komenda Główna Policji nie prezentuje danych na temat obecności lub braku alkoholu we krwi u pozostałych 3792 osób podejmujących zamachy samobójcze. Jako najczęstszą przyczynę śmierci samobójczej KGP wymienia choroby psychiczne (817 zamachów samobójczych w 2009 r.) [3]. W niemal połowie przypadków nie udaje się ustalić przyczyny decyzji o odebraniu sobie życia. Z analizy tendencji na przestrzeni ostatnich lat wynika, że najczęściej śmiercią samobójczą giną ludzie młodzi — w wieku 16–21 lat oraz osoby w średnim wieku (45–55 lat), częściej mężczyźni. Najczęstszą metodą odebrania sobie życia jest powieszenie, stanowiące przyczynę około 75% przypadków śmierci. Skok z wysokości i zamierzone zatrucie środkami nasennymi sumują się w kolejne 10% przypadków. Rzadziej wybierane metody to: uszkodzenie naczyń krwionośnych i inne samookalecze-
Early nutritional support for extremely premature infants: what amino acid amount should be given?

Consistently providing adequate nutrition to extremely preterm infants remains a clinical challenge. This is especially true in early postnatal life, when support is largely dependent on parenteral nutrition and often complicated by glucose and lipid intolerance. Large nutritional deﬁcits, in particular protein deﬁcits, can rapidly accumulate in extremely preterm infants. Without amino acid intake, the protein stores of extremely preterm infants are diminished by 1.5%/d, whereas the fetus is accumulating protein at 2%/d (1). Multiple studies have shown that early amino acid intake in very-low-birth-weight infants can improve protein bal-ance and minimize protein deﬁcits (2, 3). A large observational trial showed signiﬁcantly improved growth outcomes at 36 wk corrected gestational age in extremely-low-birth-weight (ELBW) infants who received at least 3 g amino acids · kg –1 · d –1 before 5 d of life (4). A number of single-site observational trials also reported improved growth outcomes with increased early amino acid delivery to very-low-birth-weight infants (5, 6). Some randomized controlled trials of higher amounts of amino acid intake reported improved growth outcomes in premature infants (7, 8), although some did not (9). Although early parenteral nutrition support appears to be a beneﬁcial clinical strategy, the optimal amount of that support is not fully known.