Miracle-dz/UniFAR-FTUs huggingface dataset:
Radiolarians from the Emperor Seamounts of the Northwest Pacific: Leg 55 of the Deep Sea Drilling Project

When the prospectus for Leg 55 was presented, it outlined two separate objectives: first, to drill into seamounts of the Emperor chain in the northwestern Pacific, and second, to recover sediments of the Mesozoic Pacific crust on the oceanic side of the Kurile Trench, east of Hokkaido, Japan. Accordingly, the purposes of my participation in the cruise were (1) to relate previous radiolarian zonation of highand middle-latitude regions to that of the tropical Pacific; (2) to seek Mesozoic biostratigraphic succession in this far western corner of North Pacific; and (3) if possible, to relate this succession to that of land sections of Hokkaido. However, as the D/V Glomar Challenger finally sailed from Honolulu, Hawaii on 22 August 1977, after several postponements that delayed departure by more than one month, the shipboard scientists were belatedly informed that the drilling for Mesozoic crust was cancelled. Consequently, the scope of this report is necessarily more limited than had been anticipated. Methods of laboratory treatment of the cored sediments, and of recording the illustrated specimens in the strewn slides with an application of England Finder, are essentially the same as those of the previous reports (Ling, 1973, 1975, 1979). Relative abundance (A, abundant; C, common; F, frequent, R, rare) and state of preservation (G, good; F, fair; P, poor) are repeated according to the shipboard paleontological format. All the slides examined during the study discussed herein will be deposited permanently in the micropaleontological collection, Department of Oceanography, University of Washington, Seattle, Washington.
Physicochemical Quantitative Analysis of the Oil–Water Interface as Affected by the Mutual Interactions between Pea Protein Isolate and Mono- and Diglycerides

As a commercially available ingredient, the mono- and diglycerides (MDG) were widely used in a plant protein-based emulsion to provide effective, functional, emulsifying properties. The simultaneous addition of the MDG and pea protein isolate (PPI) was investigated by the methods of interfacial rheology and quantitative protein proteomics. The physicochemical quantitative analysis of the oil–water interface revealed an interfacial stability mechanism for the protein adsorption layer. For a low MDG concentration, the interfacial quantities of vicilin and albumin were increased, which could be attributed to the adsorption rate. For a high MDG concentration, both vicilin and albumin were displaced by MDG and desorbed from the interface, while legumin was more difficult to displace due to its slow adsorption and the complex structure of protein molecules. The protein molecules with the structural rearrangement interacted with MDG, exhibiting potential effects on the interfacial film structure. Combined with some nanotechnologies, the new comprehension of protein-emulsifier interactions may promote food delivery systems. The research aims to develop an in-depth analysis of interfacial proteins, and provide more innovative and tailored functionalities for the application of the plant protein emulsion.
Nrf2, A Target for Precision Oncology in Cancer Prognosis and Treatment

Activating nuclear factor-erythroid 2-related factor (Nrf2), a master regulator of redox homeostasis, has been shown to suppress initiation of carcinogenesis in normal cells. However, this transcription factor has recently been reported to promote proliferation of some transformed or cancerous cells. In tumor cells, Nrf2 is prone to mutations that result in stabilization and concurrent accumulation of its protein product. A hyperactivated mutant form of Nrf2 could support the cancer cells for enhanced proliferation, invasiveness, and resistance to chemotherapeutic agents and radiotherapy, which are associated with a poor clinical outcome. Hence understanding mutations in Nrf2 would have a significant impact on the prognosis and treatment of cancer in the era of precision medicine. This perspective would provide an insight into the genetic alterations in Nrf2 and suggest the application of small molecules, RNAi, and genome editing technologies, particularly CRISR-Cas9, in therapeutic intervention of cancer in the context of the involvement of Nrf2 mutations.
Mixotrophic and heterotrophic cultivation of different microalgae species on dairy by-products for further supplementation of poultry diet

Use of alternative cultivation substrates, for instance dairy industry by-products, can significantly reduce the production costs of microalgal biomass. However, dairy by-products are found to be problematic co-substrate for many microalgae, due to inability to hydrolyse lactose. The focus of this study was to assess the ability of microalgal strains to produce biomass in media supplemented with lactose, glucose and galactose. Among them only microalgae Chromochloris zofingiensis was capable to assimilate effectively all three sugars.
Gamification Project to Receive Continuous Feedback in the Context of the Evolution of Public Service for Lawyers

Contribution: The main contribution presented by this work was proposing a method for building gamification projects that can be replicated in teaching applied computing, developing new software solutions, or creating gamification projects for other areas. The exposed methodology not only proposes a solution to engage people in favor of learning objectives effectively but also presents two distinct gamification approaches using the same framework that can be used separately or together depending on the complexity of the application scenario. The implementation of this methodology can contribute to the advancement of knowledge in the field of gamification and motivation, enabling future studies to analyze the effectiveness of the proposed techniques and improve engagement strategies. Background: There are various contexts in which spontaneous user action is necessary or desirable, such as exercising the right to vote in a democracy or attending an algebra class. In both cases, motivation can be crucial in how an individual engages in these activities. Self-determination theory suggests that both extrinsic and intrinsic motivation can promote such engagement. Gamification, through motivational elements known as game techniques, allows for creating an immersive environment for specific activities. The focus is on adapting the approach to achieve a goal that is aligned with the motivational and behavioral profile of the participants. Intended outcomes: This approach was employed in a real-life case to propose a gamification solution that motivates participating lawyers in trial sessions of a Brazilian higher court to provide spontaneous, contextualized, neutral, and frequent feedback. Application design: This work proposes the development of a gamification project by merging two assessments based on the Octalysis gamification framework: one to identify motivation techniques based on expert opinions in the field of study and another to identify motivation techniques by mapping the motivational factors of the participant persona using self-determination theory. The final gamification project is the proposal of Octalysis techniques for each core driver resulting from the merging of the assessments. Findings: The proposed gamification project resulted in 16 techniques distributed among 7 core drivers of the Octalysis framework. At the end of the project, the techniques to be used in the gamification design are presented. The proposed approach, based on merging assessments and applying the Octalysis framework, can be applied in different contexts and activities, always to increase engagement and motivation among the individuals involved.
Evaluation of the Antibacterial, Anti-Cervical Cancer Capacity, and Biocompatibility of Different Graphene Oxides

Cancer stands as one of the deadliest diseases in human history, marked by an inferior prognosis. While traditional therapeutic methods like surgery, chemotherapy, and radiation have demonstrated success in inhibiting tumor cell growth, their side effects often limit overall benefits and patient acceptance. In this regard, three different graphene oxides (GO) with variations in their degrees of oxidation were studied chemically and tissue-wise. The accuracy of the synthesis of the different GO was verified by robust techniques using X-ray photoelectron spectroscopy (XPS), as well as conventional techniques such as infrared spectroscopy (FTIR), RAMAN spectroscopy, and X-ray diffraction (XRD). The presence of oxygenated groups was of great importance. It affected the physicochemical properties of each of the different graphene oxides demonstrated in the presence of new vibrational modes related to the formation of new bonds promoted by the graphitization of the materials. The toxicity analysis in the Hep-2 cell line of graphene oxide formulations at 250 µg/mL on the viability and proliferation of these tumor cells showed low activity. GO formulations did not show high antibacterial activity against Staphylococcus aureus and Escherichia coli strains. However, the different graphene oxides showed biocompatibility in the subdermal implantation model for 30, 60, and 90 days in the biomodels. This allowed healing by restoring hair and tissue architecture without triggering an aggressive immune response.
Is endovascular treatment still good for acute ischemic stroke in the elderly? A meta-analysis of observational studies in the last decade

Background The lack of randomized evidence makes it difficult to establish reliable treatment recommendations for endovascular treatment (EVT) in elderly patients. This meta-analysis aims to evaluate the therapeutic effects of endovascular treatment for acute ischemic stroke in the elderly compared with younger patients. Methods Comprehensive literature retrieval was conducted to identify studies that directly compared the outcomes of EVT in elderly patients and those aged <80 years. The primary outcome was functional independence, defined as mRS 0–2 at 90 days after EVT. The secondary outcomes were the rate of successful recanalization, symptomatic intracranial hemorrhage (sICH) and mortality. Odds ratios (ORs) were estimated using a random effects model. Results In total, twenty-six studies with 9,492 enrolled participants were identified. Our results showed that, compared with patients aged <80 years undergoing EVT, EVT was associated with a lower rate of functional independence at 90 days (OR = 0.38; 95% CI, 0.33–0.45; p < 0.00001) and a higher mortality rate (OR = 2.51; 95% CI, 1.98–3.18; p < 0.00001) in the elderly. Furthermore, even without a significantly observed increase in sICH (OR = 1.19; 95% CI, 0.96–1.47; p = 0.11), EVT appeared to be associated with a lower rate of successful recanalization (OR = 0.81; 95% CI, 0.68–0.96; p = 0.02). Conclusion Evidence from observational studies revealed that EVT has less functional outcomes in elderly patients with acute ischemic stroke. Further studies are needed to better identify patients aged ≥80 years who could potentially benefit from EVT.
The Use of Social Media for Urban Planning

User data created in the digital context has increasingly been of interest to analysis and spatial analysis in particular. Large scale computer user management systems such as digital ticketing and social networking are creating vast amount of data. Such data systems can contain information generated by potentially millions of individuals. This kind of data has been termed big data. The analysis of big data can in its spatial but also in a temporal and social nature be of much interest for analysis in the context of cities and urban areas. This chapter discusses this potential along with a selection of sample work and an in-depth case study. Hereby the focus is mainly on the use and employment of insight gained from social media data, especially the Twitter platform, in regards to cities and urban environments. The first part of the chapter discusses a range of examples that make use of big data and the mapping of digital social network data. The second part discusses the way the data is collected and processed. An important section is dedicated to the aspects of ethical considerations. A summary and an outlook are discussed at the end.
Silicon-Based Metal Grating Structure for ZnO Surface Plasmon Polariton Nanolasers

Silicon-based photonics integration has significant application prospects in optical interconnection. Highperformance miniaturized silicon-based light sources are the future development trend of silicon-based photonics integration. Surface plasmon-based nanolasers are novel technical means for realizing miniaturized silicon-based light sources, which replace photons with surface plasmon to break through the diffraction limit and achieve resonance in nano-scale cavities. In this study, we introduced a metal grating structure to replace the previous flat metal layer in ZnO surface plasmon resonance lasers. This new structure effectively improves the efficiency of SPP excitation and radiation, the laser emission energy is increased by about 1.5 times than conventional photon laser. This letter is expected to make a breakthrough in silicon-based nanolasers, provide a certain theoretical and experimental research foundation for silicon photonics integrated light sources.
ROMANIA’S SPACE ASPIRATIONS AND THE EU SPACE STRATEGY FOR SECURITY AND DEFENCE

The article explores the interplay between European Union’s Space Strategy for Security and Defence and Romania’s space aspirations, analysing its key facets and their potential effects. As space gains significance for security and defence of the EU as a whole, understanding its opportunities and challenges is crucial. Investigating elements such as shared threat awareness, space system resilience, response strategies, and responsible behaviour in outer space, the article provides insights for stakeholders to harness EU space capabilities. The article concludes by assessing implications for the domestic realm. EU Space Strategy for Security and Defence addresses space intricacies with political, operational and other fields of action. By focusing on vital components such as threat understanding, system protection, responsive measures, and cooperative behaviour, the article sheds light on EU Space Strategy’s strategic importance in the defence and security realms.
The Development of an Advanced Model for Multilayer Human Skin Reconstruction In Vivo

Human skin reconstruction on immune-deficient mice has become indispensable for in vivo studies performed in basic research and translational laboratories. Further advancements in making sustainable, prolonged skin equivalents to study new therapeutic interventions rely on reproducible models utilizing patient-derived cells and natural three-dimensional culture conditions mimicking the structure of living skin. Here, we present a novel step-by-step protocol for grafting human skin cells onto immunocompromised mice that requires low starting cell numbers, which is essential when primary patient cells are limited for modeling skin conditions. The core elements of our method are the sequential transplantation of fibroblasts followed by keratinocytes seeded into a fibrin-based hydrogel in a silicone chamber. We optimized the fibrin gel formulation, timing for gel polymerization in vivo, cell culture conditions, and seeding density to make a robust and efficient grafting protocol. Using this approach, we can successfully engraft as few as 1.0 × 106 fresh and 2.0 × 106 frozen-then-thawed keratinocytes per 1.4 cm2 of the wound area. Additionally, it was concluded that a successful layer-by-layer engraftment of skin cells in vivo could be obtained without labor-intensive and costly methodologies such as bioprinting or engineering complex skin equivalents. Key features • Expands upon the conventional skin chamber assay method (Wang et al., 2000) to generate high-quality skin grafts using a minimal number of cultured skin cells. • The proposed approach allows the use of frozen-then-thawed keratinocytes and fibroblasts in surgical procedures. • This system holds promise for evaluating the functionality of skin cells derived from induced pluripotent stem cells and replicating various skin phenotypes. • The entire process, from thawing skin cells to establishing the graft, requires 54 days. Graphical overview
Emulation of Virtual Inertia to Accommodate Higher Penetration Levels of Distributed Generation in Power Grids

A novel control scheme based on a new stochastic equivalent model of the power system, which provides flexible inertia constant to enable high penetration levels of microgrid (MG) generation, is proposed. The approach combines an adaptive energy storage system (ESS) dispatch strategy with an MG-controlled islanding scheme to provide frequency support for the host power grid. First, a center-of-gravity (COG) formulation of the inertia-control scheme is proposed, in which the unbalance torques between the control areas and the COG are used to reduce frequency deviations. An application example-based equivalent model of ESSs as seen from the grid side is then proposed that takes advantage of the ESS special attributes to contribute to inertial response. Simulation results on two test systems demonstrate the efficiency of the proposed control scheme to increase the host grid ability to efficiently integrate multiple MGs. Numerical tests suggest that the proposed control scheme increases system penetration level at least by 12%, which justifies the use of inertia emulation techniques to accommodate higher levels of distributed generation.
Extreme lymphocytosis in a dog with T-zone lymphoma

Background: Canine T-zone lymphoma (TZL) is recognized as an indolent CD45-T cell lymphoma, with low aggressiveness and high overall survival. The diagnosis is obtained by histopathology and immunohistochemistry, but also by cytological examination of the lymph node associated with immunophenotyping. Lymphocytosis is commonly identified as around 10,000 cells/µl and may reach 30,760 cells/µl. Case Description: The present report describes a case of a female Golden Retriever, nine years old, with generalized lymphadenopathy. In the cytological examination of the superficial cervical lymph node, a monomorphic population of small, “clear cells” and “hand mirror” lymphocyte shape was suggestive of TZL. The leukogram showed intense leukocytosis (160,050 cells/μl) due to small clear cell lymphocytosis (152,048 cells/μl). The myelogram showed a myeloid:erythroid ratio of 2:3; with a pyramidal distribution of cell types and the presence of 22.8% of lymphocytes in the differential count. Bone marrow, peripheral blood, and lymph node immunophenotyping resulted in lymphocyte gates with 97.3% to 99.5% CD5+, predominantly CD4-, CD8-, and CD45- confirming the diagnosis of TZL with associated leukemia. Treatment with chlorambucil and prednisolone was started. During the first month, the lymphocytosis remained above 200,000 cells/uL. After four months of treatment, there was a decrease in lymphocytes, which progressively reached a count of 10,800 cells/ul in the eleventh month. Conclusion: In the literature, lymphocytosis above 30,760 cells/μl has not been observed in TZLs. Thus, it is believed that this is the first report of extreme lymphocytosis with a slow response to chemotherapy.
ANALYSIS OF SOME BIOMETRIC PARAMETERS IN THE CHARACTERIZATION OF CORN EAR

The study analyzed the variation of some biometric parameters in corn ears, the 'Oana' hybrid. The experiment was carried out within ARDS Lovrin, under non-irrigated crop system conditions. The ear samples were harvested at physiological maturity. The analyzed parameters were represented by: ear length (EL), row number (RN), grains number on rows (GNR), ear weight (CW), grains weight (GW) and cob weight (CW). Ear length varied between EL = 18.00 – 20.75±0.41 cm; row number presented values between RN = 16.00 – 16.50±0.11; grains number on rows presented values between GNR = 43.75 – 49.25±0.76; ear weight presented the values EW = 0.86 – 1.04±0.03 kg; grains weight varied between GW = 0.73 – 0.87±0.03 kg; cob weight varied between CW = 0.13 - 0.17±0.01 kg. The Anova test confirmed the presence of variance and the statistical reliability of the recorded data (F calculated > F crit, p<0.001; Alpha = 0.001). High variability was recorded in the case of cob weight (CV=10.1184), and low variability in the case of row number (CV=1.5971). Intermediate values were recorded for the other analyzed parameters, respectively CV = 4.0769 for GNR, CV = 5.3064 for EL, CV = 7.6181 for GW, respectively CV = 7.9539 for EW. Correlation of varying intensity levels was recorded between analyzed parameters (e.g. r=0.991 between EW and GW; r=0.949 between EL and GNR; r=0.845 between CW and EW). The regression analysis facilitated the finding of equations and graphic models that described the variation of EW and GW in relation to EL and RN parameters, under statistical safety conditions (R2=0.982 in the case of EW; R2=0.974 in the case of GW). From the equations obtained (values of the coefficients) as well as from the graphic models, it was found that the EL parameter had a determining influence (compared to RN) in the variation of the EW and GW parameters.
Study and valorization of a new bituminous concrete based on natural dune sand for hot and arid environments

The trans-desert road network is exposed to enormous degradation of asphalt concrete pavements due to the high temperatures of these arid regions, which considerably accelerate asphalt ageing. Common bituminous mixes generally use quarry sand fillers, the proportions of which are poorly controlled due to the diversity of rock deposits and their manufacturing conditions. This article responds to this problem by proposing dune sand as a source of filler by grinding it and then introducing it into pure bitumen to obtain the bitumen-filler mix. In this paper, two types of analysis were carried out, one thermal and the other mechanical to study the influence of the substitution of quarry sand filler by dune sand filler in asphalt concrete. In the thermal analysis, the study evaluates the stiffening power (? TBA) of three types of fillers incorporated into a pure bitumen, namely quarry sand, dune sand and standardized filler. The results of these analyses reveal that at a normative percentage of 57% filler with 43% pure bitumen, the stiffening power (? TBA) of dune sand filler and normalized filler comply with established standards (between 8 and 16°C), unlike quarry sand filler, which does not meet standards. The mechanical analysis carried out on quarry sand filler and dune sand filler revealed an improvement in mechanical performance when dune sand filler was used, with MARSHALL stability values indicating an average increase from 3.9 to 4.9, and better resistance to water with a greater than 99% ratio for the DURIEZ test well above the 75% threshold. These results offer the potential to optimize bituminous mixes by incorporating dune sand fillers, thereby enabling Saharan roads to be built more quickly, at lower cost and, above all, to extend their lifespan, making a positive contribution to the development of road infrastructure in hot, arid environments.