Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-Term Outcomes Following Hepatic Resection and Radiofrequency Ablation of Colorectal Liver Metastases

Recently some have called for randomized controlled trials comparing RFA to hepatic resection, particularly for patients with only a few small metastases. The objectives were to compare local recurrence and survival following RFA and hepatic resection for colorectal liver metastases. This was a retrospective review of open RFA and hepatic resection for colorectal liver metastases between January 1998 and May 2007. All patients who had RFA were considered to have unresectable disease. 58 patients had hepatic resection and 43 had RFA. A 5-year survival after resection was 43% compared to 23% after RFA. For patients with solitary lesions, a 5-year survival was 48% after resection and 15% after RFA. Sixty percent of patients suffered local recurrences after RFA compared to 7% after hepatic resection. RFA is inferior to resection. The results observed in this study support the consensus that RFA cannot be considered an equivalent procedure to hepatic resection.
Solving Seven Open Problems of Offline and Online Control in Borda Elections

Standard (offline) control scenarios in elections (such as adding, deleting, or partitioning either voters or candidates) have been studied for many voting systems, natural and less natural ones, and the related control problems have been classified in terms of their complexity. However, for one of the most important natural voting systems, the Borda Count, only a few such complexity results are known. We reduce the number of missing cases by pinpointing the complexity of three control scenarios for Borda elections, including some that arguably are among the practically most relevant ones. We also study online candidate control, an interesting dynamical, partial-information model due to Hemaspaandra et al. (2012a), who mainly focused on general complexity bounds by constructing artificial voting systems—only recently they succeeded in classifying four problems of online candidate control for one natural voting system: sequential plurality (Hemaspaandra et al. 2016). We settle the complexity of another four natural cases: constructive and destructive online control by deleting and adding candidates in sequential Borda elections.
Apoprotein structure in the LH2 complex from Rhodopseudomonas acidophila strain 10050: modular assembly and protein pigment interactions.

The refined structure of the peripheral light-harvesting complex from Rhodopseudomonas acidophila strain 10050 reveals a membrane protein with protein-protein interactions in the trans-membrane region exclusively of a van der Waals nature. The dominant factors in the formation of the complex appear to be extramembranous hydrogen bonds (suggesting that each apoprotein must achieve a fold close to its final structure in order to oligomerize), protein-pigment and pigment-pigment interactions within the membrane-spanning region. The pigment molecules are known to play an important role in the formation of bacterial light-harvesters, and their extensive mediation of structural contacts within the membrane bears this out. Amino acid residues determining the secondary structure of the apoproteins influence the oligomeric state of the complex. The assembly of the pigment array is governed by the apoproteins of LH2. The particular environment of each of the pigment molecules is, however, influenced directly by few protein contacts. These contacts produce functional effects that are not attributable to a single cause, e.g. the arrangement of an overlapping cycle of chromophores not only provides energy delocalisation and storage properties, but also has consequences for oligomer size, pigment distortion modes and pigment chemical environment, all of which modify the precise function of the complex. The evaluation of site energies for the pigment array requires the consideration of a number of effects, including heterogeneous pigment distortions, charge distributions in the local environment and mechanical interactions.
Bootstrapping to Evaluate Accuracy of Citation-Based Journal Indicators

Introduction Bibliometric indicators ranking aggregate units have a long tradition, including criticisms of methodology, interpretation and application. Despite the criticism, there is a demand for these indicators, and recent developments have led to improvements of methodology and interpretation. An essential element of these interpretations is to provide estimates of the accuracy, robustness, stability and confidence of bibliometric indicators, thereby providing the reader with data required to interpret results. This has, for example, been demonstrated for the set of indicators in the Leiden ranking (Waltman et al., 2012), the Journal Impact Factor (Chen, Jen, & Wu, 2014) and other journal indicators (Andersen, Christensen, & Schneider, 2012) as well as author metrics (Lehmann, Jackson, & Lautrup, 2008). The present study applies the same type of bootstrapping technique to estimate stability, as is used in the Leiden ranking (Waltman et al., 2012), on an array of citation-based journal indicators. The purpose of this analysis is to compare recent methodological advances, as well as traditional approaches. The study is based on clinical medicine journals in the Web of Science (WoS).
Poster : A Secure control plane with Dynamic Multi-NOS for SDN

Vulnerabilities and backdoors in NOS (Network operating system) allow malicious actors to disrupt network or hijack NOS. The current work proposes a NOS architecture called secure control plane (SCP) that enhances security through a rotation of hetergeneous and multiple NOSs.Theory analysis proves validity and availability of the SCP and its more effective security performance over traditional architectures.
Compositional Specification and Verification for System-on-chip Design

The main objective of the proposed project is to develop a framework and method for system-onchip designwhich allows system components to be specified and verified on a level of abstra which is sufficiently high to allow formal analysis and verification, but at the same time is deta enough to allow synthesis of efficient implementations. It is the functionalityof the components that we are interested in at this level of abstraction. The framework should support modular design , i.e. it should allow analysis/verification of the functionality, performance and cost of a compound sy based solely on the specification of the functionality, performance and cost of its components. The framework should consist of the following key ingredients: aspecification language for describing the functionality of systems/components; a requirement definition language for describing the properties of systems/components; aproof system for inferring system properties from the properties of the components. This framework should support a verification method which combines model-checking techn for verification of the components as well as theorem-proving techniques for verification of the pound system. To evaluate the method, a prototype interactive proof-assistantool supporting the verification method should be developed and tested on some toy and industrial-size case studie multiple antenna demonstration system will be considered as case study to prove the usefulnes method for wireless telecom systems. We will use existing notations and languages as much as possible and consider developm extensions and new notations only when necessary and appropriate.
Improving spark application throughput via memory aware task co-location: a mixture of experts approach

Data analytic applications built upon big data processing frameworks such as Apache Spark are an important class of applications. Many of these applications are not latency-sensitive and thus can run as batch jobs in data centers. By running multiple applications on a computing host, task co-location can significantly improve the server utilization and system throughput. However, effective task co-location is a non-trivial task, as it requires an understanding of the computing resource requirement of the co-running applications, in order to determine what tasks, and how many of them, can be co-located. State-of-the-art co-location schemes either require the user to supply the resource demands which are often far beyond what is needed; or use a one-size-fits-all function to estimate the requirement, which, unfortunately, is unlikely to capture the diverse behaviors of applications. In this paper, we present a mixture-of-experts approach to model the memory behavior of Spark applications. We achieve this by learning, off-line, a range of specialized memory models on a range of typical applications; we then determine at runtime which of the memory models, or experts, best describes the memory behavior of the target application. We show that by accurately estimating the resource level that is needed, a co-location scheme can effectively determine how many applications can be co-located on the same host to improve the system throughput, by taking into consideration the memory and CPU requirements of co-running application tasks. Our technique is applied to a set of representative data analytic applications built upon the Apache Spark framework. We evaluated our approach for system throughput and average normalized turnaround time on a multi-core cluster. Our approach achieves over 83.9% of the performance delivered using an ideal memory predictor. We obtain, on average, 8.69x improvement on system throughput and a 49% reduction on turnaround time over executing application tasks in isolation, which translates to a 1.28x and 1.68x improvement over a state-of-the-art co-location scheme for system throughput and turnaround time respectively.
Establishing timing requirements and control attributes for control loops in real-time systems

Advances in scheduling theory have given designers of control systems greater flexibility over their choice of timing requirements. Advances in scheduling theory have given designers of control systems greater flexibility over their choice of timing requirements. This could lead to systems becoming more responsive, more flexible and more maintainable. However, experience has shown that engineers find it difficult to exploit these advantages due o the difficulty in determining the "real" timing requirements of systems and therefore the techniques have delivered less benefit than expected. Part of the reason for this is that the models used by engineers when developing systems do not allow for emergent properties such as timing. This paper presents an approach and framework for addressing the problem of identifying an appropriate and valid set of timing requirements and their corresponding control parameters based on a combination of static analysis and simulation.
Systematic siRNAScreenUnmasksNSCLCGrowth Dependence by Palmitoyltransferase DHHC 5

Protein S-palmitoylation is a widespread and dynamic posttranslationalmodification that regulates protein–membrane interactions, protein–protein interactions, and protein stability. A large family of palmitoyl acyl transferases, termed theDHHC family due to the presence of a common catalytic motif, catalyzes S-palmitoylation; the role of these enzymes in cancer is largely unexplored. In this study, anRNAi-based screen targeting all 23members of the DHHC family was conducted to examine the effects on the growth in non–small cell lung cancer (NSCLC). Interestingly, siRNAs directed against DHHC5 broadly inhibited the growth ofmultiple NSCLC lines but not normal human bronchial epithelial cell (HBEC) lines. Silencing of DHHC5 by lentivirus-mediated expression of DHHC5 shRNAs dramatically reduced in vitro cell proliferation, colony formation, and cell invasion in a subset of cell lines that were examined in further detail. The phenotypeswere restored by transfection of a wild-type DHHC5 plasmid but not by a plasmid expressing a catalytically inactive DHHC5. Tumor xenograft formationwas severely inhibited byDHHC5knockdownand rescued by DHHC5 expression, using both a conventional and tetracycline-inducible shRNA. Thesedata indicate thatDHHC5has oncogenic capacity and contributes to tumor formation inNSCLC, thus representing a potential novel therapeutic target. Implications: Inhibitors of DHHC5 enzyme activity may inhibit non–small cell lung cancer growth. Mol Cancer Res; 13(4); 784–94.
Investigation of relationship with automatic thoughts and the status of women's exposure to violence by adolescents children Kadınların ergen çocukları tarafından şiddete maruz bırakılma durumu ve otomatik düşünceler ile ilişkisinin incelenmesi

Purpose: The purpose of study is to investigation of relationship with automatic thoughts and the status of women's exposure to violence by adolescents children. Materials and Methods: Descriptive research, was made between January 2010 - December 2011. The sample has not been selected in this study. Six hundred seventy one (n=671) women who have at least one adolescent child accepted to join in this research study and replied all questions thoroughly. Socio-demographic characteristics and data about violence prepared by the researchers "Information Form", the data about automatic thoughts were collected using Automatic Thoughts Scale (ATS). ATS is developed to determine the frequency of occurrence of negative automatic thoughts the person himself. The research was adapted to Turkish by Aydin and Aydin (1990). Data were evaluated using percentage, mean and standard deviation on computer. Findings: In this study was found to be significantly more frequent negative automatic thoughts in women exposed to violence by adolescent children than unexposed. Women who are subjected to violence was expolered experienced negative emotions such as intense anxiety, fear, helplessness, anger, children born to hate, feelings of worthlessness. Ozet Amac: Calismanin amaci kadinlarin ergen cocuklari tarafindan siddete maruz birakilma durumu ve olumsuz otomatik dusunceleri ile iliskisinin incelenmesidir. Materyal and Method: Tanimlayici olan arastirma Ocak 2010- Aralik 2011 yillari arasinda yapilmistir. Calismada orneklem secimine gidilmemistir. Bu calismaya ergenlik doneminde en az bir ergen cocugu olan, arastirmaya katilmayi kabul eden ve sorulari eksiksiz yanitlayan alti yuz yetmis bir (n=671) kadin katilmistir. Sosyodemografik ozellikler ve siddetle ilgili veriler arastirmacilar tarafindan hazirlanan “Bilgi Formu”, otomatik dusunceler ile ilgili veriler Otomatik Dusunceler Olcegi (ODO) kullanilarak toplanmistir. ODO; kisinin kendine yonelik olumsuz otomatik dusuncelerinin ortaya cikma sikligini belirlemek amaciyla gelistirilmistir. Aydin ve Aydin (1990) tarafindan Turkce’ye uyarlanmistir. Veriler bilgisayar ortaminda yuzdelik, ortalama ve standart sapma kullanilarak degerlendirilmistir. Bulgular: Calismada, ergen cocugu tarafindan siddete maruz birakilan kadinlarda olumsuz otomatik dusuncelerin, siddete maruz kalmayanlara oranla anlamli olarak daha sik oldugu bulunmustur. Şiddete maruz birakilan kadinlar yogun endise, korku, caresizlik, ofke, cocugundan nefret etme, kendini degersiz bulma gibi olumsuz duygular hissettiklerini ifade etmistir.
Magnitude and Mechanism of Siderophore-Mediated Competition at Low Iron Solubility in the Pseudomonas aeruginosa Pyochelin System

A central question in microbial ecology is whether microbial interactions are predominantly cooperative or competitive. The secretion of siderophores, microbial iron chelators, is a model system for cooperative interactions. However, siderophores have also been shown to mediate competition by sequestering available iron and making it unavailable to competitors. The details of how siderophores mediate competition are not well understood, especially considering the complex distribution of iron phases in the environment. One pertinent question is whether sequestering iron through siderophores can indeed be effective in natural conditions; many natural environments are characterized by large pools of precipitated iron, and it is conceivable that any soluble iron that is sequestered by siderophores is replenished by the dissolution of these precipitated iron sources. Our goal here was to address this issue, and investigate the magnitude and mechanism of siderophore-mediated competition in the presence of precipitated iron. We combined experimental work with thermodynamic modeling, using Pseudomonas aeruginosa as a model system and ferrihydrite precipitates as the iron source with low solubility. Our experiments show that competitive growth inhibition by the siderophore pyochelin is indeed efficient, and that inhibition of a competitor can even have a stronger growth-promoting effect than solubilization of precipitated iron. Based on the results of our thermodynamic models we conclude that the observed inhibition of a competitor is effective because sequestered iron is only very slowly replenished by the dissolution of precipitated iron. Our research highlights the importance of competitive benefits mediated by siderophores, and underlines that the dynamics of siderophore production and uptake in environmental communities could be a signature of competitive, not just cooperative, dynamics.
The Influence of CCL3L1 Gene-Containing Segmental Duplications on HIV-1/AIDS Susceptibility

Segmental duplications in the human genome are selectively enriched for genes involved in immunity, although the phenotypic consequences for host defense are unknown. We show that there are significant interindividual and interpopulation differences in the copy number of a segmental duplication encompassing the gene encoding CCL3L1 (MIP-1αP), a potent human immunodeficiency virus–1 (HIV-1)–suppressive chemokine and ligand for the HIV coreceptor CCR5. Possession of a CCL3L1 copy number lower than the population average is associated with markedly enhanced HIV/acquired immunodeficiency syndrome (AIDS) susceptibility. This susceptibility is even greater in individuals who also possess disease-accelerating CCR5 genotypes. This relationship between CCL3L1 dose and altered HIV/AIDS susceptibility points to a central role for CCL3L1 in HIV/AIDS pathogenesis and indicates that differences in the dose of immune response genes may constitute a genetic basis for variable responses to infectious diseases.
A 2-Approximation Algorithm for Scheduling Independent Tasks onto a Uniform Parallel Machine and its Extension to a Computational Grid

First, this paper gives a very simple 2-approximation algorithm for scheduling n independent tasks onto a uniform parallel machine with m processors. Best known results so far are (1 + epsiv)-approximation algorithm (0 < epsiv les 1) which runs in exponential in (1/epsiv) time and 2-approximation algorithm based on LP-rounding technique which runs in O((mn)3.5L2) time where L is the bit length of the linear program. In contrast, the proposed algorithm runs in O(n log n + mn) time. Next, this paper proves that, if a criterion of a schedule is total computing power consumed by the schedule and accurate performance prediction is possible, the proposed algorithm is a 2-approximation algorithm also for a uniform parallel machine such that processor speed varies over time. Such a parallel machine corresponds to a so-called desktop grid
Sensorless control of wound rotor synchronous machines using the switching of the rotor chopper as a carrier signal

Wound rotor synchronous machines open up new possibilities in carrier signal based sensorless control since the rotor voltage serves as an additional input to the system and the field current as an additional, easy to measure, state variable. Approaches for sensorless control of PMSMs use the stator as the transmitter and as the receiver of the carrier signal. A new alternative for wound rotor synchronous machines is to use the field winding as the transmitter and the stator as receiver. Since the field inductance is usually very large, a signal injection into the rotor is not reasonable because large rotor voltages are obligatory to create detectable stator currents. Therefore the presented approaches make use of the switching of the dc-field chopper as a carrier signal. Two methods are compared: The first method evaluates the stator currents in rotor fixed coordinates using a tracking observer. The second one uses the stator currents in stator fixed coordinates to directly compute the rotor position. Both methods consider cross saturation effects. In contrast to approaches for carrier signal based sensorless control of PMSMs no differential magnetic saliency is mandatory. Moreover no additional signal injection is necessary. Experimental results prove the performance of the proposed methods.
Integrated flexible microactuator systems

SUMMARY The flexible microactuator (FMA) is a novel pneumaticrubber actuator developed for use in microrobots. Thispaper reports on integrated FMA systems to achievedistributed motion as occurs in intestinal villi, and withmulti-legged arthropods such as centipedes. For the purpose of miniaturization and integration of FMAs, the authors focussed on two technical issues: A new fabrication process based on stereo lithography and a new FMA design called a restraint beam FMA. Stereo lithography enables fabrication of micro-structures with rubber-like materials suitable for integrated FMAs. The restraint beam FMA makes it possible to fabricate FMAs from a single material, allowing stereo lithography to be used. As examples of integrated FMA systems, four prototypes are shown: a 5 × 5 FMA array, a 3 × 3 FMA array which has pneumatic circuits at its base, a pipe interior mobile robot, and an amusement system consisting of 30 FMAs, which demonstrates ball handling ability.
Semi-supervised learning with path-based similarity measure for face recognition

In this paper, we proposed a novel semi-supervised classification method with path-based similarity measure for face recognition. Based on the manifold assumption, our method can reflect genuine similarities between data points on manifolds without any other additional knowledge, which takes into account the existence of noise and outliers in the face dataset. Comparison experiments between the proposed method and the other two methods: PCA and LDA, are performed. The results show that the proposed method achieves the best face recognition.
Reducing Student Alienation in High Schools: Implications of Theory.

Student alienation is a difficult problem facing many U. S. high schools. Not only does it adversely affect the quality of student life, but it is an underlying factor in other school problems such as violence, vandalism, and poor achievement. Drawing on an extensive literature, Fred M. Newmann develops six guidelines for reducing student alienation. The guidelines are used to show why current efforts in school reform have failed to provide a comprehensive solution to this increasingly troublesome problem.
Improving the Quality of Education for All

: The main aim of this research is reaching suggested procedures to build school capacity for continuous improvement in Egypt. The research presents a theoretical model of the ability of school improvement, analyzes in which case the Egyptian schools are, and determines the differences between accredited and not accredited schools in the ability of school improvement. The research employed the Methodology of Triangulation, so it mixes between the Quantitative and Qualitative Approach in the case study. Research uses more than a tool: (a) the questionnaire to collect quantitative data,(b) the interview to collect qualitative data. It was also relying on more than one source of data collection (teachers, school principals, and Quality officials in education departments). The research results can be summarized mainly as follows: The overall level of the ability of Egyptian schools to continuous improvement is low, and there were statistically significant differences in all dimensions of school capacity between accredited schools and non-accredited schools in the level of the ability of school improvement in favor of accredited schools.