Miracle-dz/UniFAR-FTUs huggingface dataset:
On the Eccentricities and Merger Rates of Double Neutron Star Binaries and the Creation of “Double Supernovae”

We demonstrate that a natural consequence of an asymmetric kick imparted to neutron stars at birth is that the majority of double neutron star binaries should possess highly eccentric orbits. This leads to greatly accelerated orbital decay, due to the enormous increase in the emission of gravitational radiation at periastron as originally demonstrated by Peters. A uniform distribution of kick velocities constrained to the orbital plane of the pre-supernova binary would result in ~24% of surviving binaries coalescing at least 10,000 times faster than a circular orbit system. Even if the planar kick constraint is lifted, ~6% of bound systems still coalesce this rapidly. In a nonnegligible fraction of cases it may even be possible that the system could coalesce within 10 years of the final supernova, resulting in what might resemble a "double supernova. " For systems like the progenitor of PSR J0737-3039A, this number is as high as ~9% (in the planar kick model). Whether the kick velocity distribution extends to the range required to achieve this is still unclear. We do know that the observed population of binary pulsars has a deficit of highly eccentric systems at small orbital periods. In contrast, the long-period systems favor large eccentricities, as expected. We argue that this is because the short-period highly eccentric systems have already coalesced and are thus selected against by pulsar surveys. This effect needs to be taken into account when using the scale-factor method to estimate the coalescence rate of double neutron star binaries. We therefore assert that the coalescence rate of such binaries is underestimated by a factor of several.
Work, Postsecondary Education, and Psychosocial Functioning Following the Transition From High School

Through a two-wave panel study of emerging adults, the authors examine how living situation, work and school roles, and experiences in those roles affect psychosocial functioning following the transition from high school. Enrollment in college programs and fulltime work are associated with lower levels of depressed mood and more positive quality of life. Disruptions in work roles (getting fired, an unwanted period of unemployment) are linked to higher levels of depressed mood, heavy episodic drinking, and poorer quality of life; the negative effects of disruptions in postsecondary schooling are confined to heavy episodic drinking. Open-ended data support the view that ongoing responsibilities are important for emerging adults'sense of progress toward adulthood. Findings linking heavy episodic drinking to problems in role functioning inform recent debates concerning the developmental import of alcohol use, suggesting that heavy drinking is not developmentally harmless.
Software Effort Estimation for Size Proxy Metric Framework Modelling using Software Estimation Models and Neuro Fuzzy Logic Approach

As software grew in size and requirements it also successively grew in complexity and cost. Evaluating size estimates accurately at an initial stage in the software conglomeration is of high priority. Conventional techniques have the problems of uncertainty and precision during the evaluation of size estimates. Software engineering cost models and estimation techniques are used for a number of purposes. In our work we have compared the results using three function point based effort estimation models. We have also compared MMRE, MMER, MRE, MER values by training the dataset using neuro-fuzzy logic based machine learning aapproach which overcomes the problems present in the traditional methods. In this paper effort estimates has been obtained by modeling and training the size metric framework. The dataset trained in our work is for 100 projects . Keywords—size metric, fuzzy logic software effort ,software engineering, cost estimation models, MMRE ,MER,MRE, MMER.
Towards a Blended Model of Leadership for School-based Collaborations

Interest in collaborative working has grown enormously in the last 20 years, driven by the view that partnership working may improve efficiency and add value in outcomes. As a result, collaborative working is an unavoidable feature of the 21st-century school and a consistent part of government policy for the provision of services to children. However, remarkably little research has been undertaken into the nature of leadership required to maximize the potential of such partnership based working within this context. This article outlines the findings from original research, supported by the National College for Leadership of Schools and Children’s Services, into the nature of effective collaborative leadership in schools. It finds that the demands of such leadership are markedly different from those associated with traditional models, which view the school in isolation. In response to this, it outlines a multi-dimensional model for leadership, which draws on elements of a range of existing leadership models, including authentic, relational, distributed, political and constitutive leadership. This article concludes by stating that it is only through the utilization of a blended form of leadership (Collinson and Collinson, 2006) that school leaders are able to effectively realize the potential collaborative advantage associated with partnerships working. In doing so, it highlights the significance of day-to-day leadership activity, stating that effective collaborative leadership is rooted in a focus on the mundane rather than a preoccupation with the extraordinary aspects of this role.
UNDERSTANDING IDENTITY DEVELOPMENT AND ADJUSTMENT OF YOUNG ADULT TRANSRACIAL ADOPTEES

The purpose of this qualitative study was to investigate the identity development and adjustment among young adult Transracial adoptees. To achieve this purpose, I conducted two separate interviews with four Transracially adopted adults (ages 19 to 28) and spoke about their perceptions and experiences regarding their respective identities, and their adjustments in interpersonal contexts such as education. Although the participants have positive affect about their adoption placements, the participants continue to face challenges regarding their identities. However, as adults, the participants no longer dwell on such hurdles; they consider their identities to be continuously evolving, and their maturity has enabled their adjustment to be within their control. They suggest that a key aspect to this adjustment was their early knowledge of their adoption status. The participants also feel that educators should be aware of sensitivities with respect to Transracial adoption but not intervene specifically with Transracial adoptees except in the case of bullying. Future research should expand the current study by taking a more expansive view of the topic in respect to range of participants and data collection methods.
Not quite the full story on new antiplatelets

O’Sullivan and Tejani[1][1] provide an interesting perspective on our CMAJ review article. [2][2] Because of geographic differences in the efficacy of ticagrelor, the FDA delayed approval of the drug twice and requested further data and analysis. [3][3],[4][4] Although the FDA document does identify
Structural basis for the activation of phenylalanine in the non‐ribosomal biosynthesis of gramicidin S

The non‐ribosomal synthesis of the cyclic peptide antibiotic gramicidin S is accomplished by two large multifunctional enzymes, the peptide synthetases 1 and 2. The enzyme complex contains five conserved subunits of ∼60 kDa which carry out ATP‐dependent activation of specific amino acids and share extensive regions of sequence similarity with adenylating enzymes such as firefly luciferases and acyl‐CoA ligases. We have determined the crystal structure of the N‐terminal adenylation subunit in a complex with AMP and L‐phenylalanine to 1.9 Å resolution. The 556 amino acid residue fragment is folded into two domains with the active site situated at their interface. Each domain of the enzyme has a similar topology to the corresponding domain of unliganded firefly luciferase, but a remarkable relative domain rotation of 94° occurs. This conformation places the absolutely conserved Lys517 in a position to form electrostatic interactions with both ligands. The AMP is bound with the phosphate moiety interacting with Lys517 and the hydroxyl groups of the ribose forming hydrogen bonds with Asp413. The phenylalanine substrate binds in a hydrophobic pocket with the carboxylate group interacting with Lys517 and the α‐amino group with Asp235. The structure reveals the role of the invariant residues within the superfamily of adenylate‐forming enzymes and indicates a conserved mechanism of nucleotide binding and substrate activation.
Reversal of Alcohol-Induced Dysregulation in Dopamine Network Dynamics May Rescue Maladaptive Decision-making

Alcohol is the most commonly abused substance among adolescents, promoting the development of substance use disorders and compromised decision-making in adulthood. We have previously demonstrated, with a preclinical model in rodents, that adolescent alcohol use results in adult risk-taking behavior that positively correlates with phasic dopamine transmission in response to risky options, but the underlying mechanisms remain unknown. Here, we show that adolescent alcohol use may produce maladaptive decision-making through a disruption in dopamine network dynamics via increased GABAergic transmission within the ventral tegmental area (VTA). Indeed, we find that increased phasic dopamine signaling after adolescent alcohol use is attributable to a midbrain circuit, including the input from the pedunculopontine tegmentum to the VTA. Moreover, we demonstrate that VTA dopamine neurons from adult rats exhibit enhanced IPSCs after adolescent alcohol exposure corresponding to decreased basal dopamine levels in adulthood that negatively correlate with risk-taking. Building on these findings, we develop a model where increased inhibitory tone on dopamine neurons leads to a persistent decrease in tonic dopamine levels and results in a potentiation of stimulus-evoked phasic dopamine release that may drive risky choice behavior. Based on this model, we take a pharmacological approach to the reversal of risk-taking behavior through normalization of this pattern in dopamine transmission. These results isolate the underlying circuitry involved in alcohol-induced maladaptive decision-making and identify a novel therapeutic target. SIGNIFICANCE STATEMENT One of the primary problems resulting from chronic alcohol use is persistent, maladaptive decision-making that is associated with ongoing addiction vulnerability and relapse. Indeed, studies with the Iowa Gambling Task, a standard measure of risk-based decision-making, have reliably shown that alcohol-dependent individuals make riskier, more maladaptive choices than nondependent individuals, even after periods of prolonged abstinence. Using a preclinical model, in the current work, we identify a selective disruption in dopamine network dynamics that may promote maladaptive decision-making after chronic adolescent alcohol use and demonstrate its pharmacological reversal in adulthood. Together, these results highlight a novel neural mechanism underlying heightened risk-taking behavior in alcohol-dependent individuals and provide a potential therapeutic target for further investigation.
A General SAS® Macro to Implement Optimal N:1 Propensity Score Matching Within a Maximum Radius

A propensity score is the probability that an individual will be assigned to a condition or group, given a set of covariates when the assignment is made. For example, the type of drug treatment given to a patient in a real-world setting may be non-randomly based on the patient’s age, gender, geographic location, overall health, and/or socioeconomic status when the drug is prescribed. Propensity scores are used in observational studies to reduce selection bias by matching the different groups based on these propensity score probabilities, rather than matching patients on the values of the individual covariates. Although the underlying statistical theory behind propensity score matching is complex, implementing propensity score matching by the radius method with SAS® is relatively straightforward. An output data set of each patient’s propensity score can be generated with SAS using PROC LOGISTIC, and a generalized SAS macro can do optimized N:1 propensity score matching of patients assigned to different groups within a specified radius of the propensity score difference. This paper gives the general PROC LOGISTIC syntax to generate propensity scores, and provides the SAS macro for optimized propensity score matching. A published example of the effect of comparing unmatched and propensity score matched patient groups, using the SAS programming techniques described in this paper, is presented.
Different Osteochondral Potential of Clonal Cell Lines Derived from Adult Human Trabecular Bone

Abstract: Cells derived from human trabecular bones have been shown to have multipotential differentiation ability along osteogenic, chondrogenic, and adipogenic lineages. In this study, we have derived two clonal sublines of human trabecular bone cells by means of stable transduction with human papilloma virus E6/E7 genes. Our results showed that these clonal sublines differ in their osteochondral potential, but are equally adipogenic, indicative of the heterogeneous nature of the parental cell population. The availability of these cell lines should be useful for the analysis of the mechanisms regulating the differentiation of adult mesenchymal progenitor cells.
Neurotic Personality Traits and Risk for Adverse Alcohol Outcomes: Chained Mediation through Emotional Disorder Symptoms and Drinking to Cope

ABSTRACT Background: Rates of alcohol abuse are high on Canadian postsecondary campuses. Individual trait differences have been linked to indices of alcohol use/misuse, including neurotic traits like anxiety sensitivity (AS) and hopelessness (HOP). We know little, though, about how these traits confer vulnerability. AS and HOP are related to anxiety and depression, respectively, and to drinking to cope with symptoms of those disorders. Neurotic personality may therefore increase risk of alcohol use/abuse via (1) emotional disorder symptoms and/or (2) coping drinking motives. Objectives: Allan and colleagues (2014) found chained mediation through AS-generalized anxiety-coping motives-alcohol problems and AS-depression-coping motives-alcohol problems. We sought to expand their research by investigating how emotional disorder symptoms (anxiety, depression) and specific coping motives (drinking to cope with anxiety, depression) may sequentially mediate the AS/HOP-to-hazardous alcohol use/drinking harms relationships among university students. Methods: This study used cross-sectional data collected in Fall 2014 as part of the Movember-funded Caring Campus Project (N = 1,883). The survey included the SURPS, adapted DMQ-R SF, and AUDIT-3. Results: AS and HOP were both related to hazardous alcohol and drinking harms via emotional disorder symptoms and, in turn, coping drinking motives. All indirect pathways incorporating both mediators were statistically significant, and additional evidence of partial specificity was found. Conclusions/Importance: The study's results have important implications for personality-matched interventions for addictive disorders.
Handling Data Imbalance in Automatic Facial Action Intensity Estimation

Automatic Action Unit (AU) intensity estimation is a key problem in facial expression analysis. But limited research attention has been paid to the inherent class imbalance, which usually leads to suboptimal performance. To handle the imbalance, we propose (1) a novel multiclass under-sampling method and (2) its use in an ensemble. We compare our approach with state of the art sampling methods used for AU intensity estimation. Multiple datasets and widely varying performance measures are used in the literature, making direct comparison difficult. To address these shortcomings, we compare different performance measures for AU intensity estimation and evaluate our proposed approach on three publicly available datasets, with a comparison to state of the art methods along with a cross dataset evaluation.
Metrics for Assessing Flexibility and Sustainability of Next Generation Data Centers

Recent advances in energy efficient data center (DC) design in combination with predictive optimization techniques have led to the emergence of DCs that are able to adapt their operation to their environment. Current approaches towards assessing the operational efficiency of the DCs are mostly static, disregarding the flexibility aspects of modern DCs, also failing to reflect the effects of DC optimization on their sustainability profile. In this context, eight EU research projects have joined forces to present new metrics allowing for the evaluation of DC flexibility as well as of the effects of DC optimization to their general operational efficiency. The present paper presents these metrics along with the verification methodologies employed for the evaluation of the obtained measurements and results.
Non‐electrolyte permeability of trout gills: effect of temperature and adrenaline

1. The gill permeability to various non‐electrolytes (Ps) was measured in fresh‐water and sea‐water adapted trout (Salmo gairdneri). This study was performed in vitro using a ‘head‐perfused’ preparation. The influence of temperature and adrenaline (10−6 M) on permeability to non‐electrolytes was also investigated.
Can bruxism be a sign of the temporal lobe epilepsy? Case report of a child with bruxism and hippocampal cystic lesion

Sleep bruxism is a condition of high prevalence in childhood and has multifactorial causes. However, as a sign of temporal lobe epilepsy, it seems to be a rare event. There are reports of patients with bruxism related to temporal lobe seizures, showing that, exceptionally, an event such as teeth grinding may not be just a parasomnia. We present a child with bruxism, whose brain resonance shows cystic lesion compatible with choroid fissure cyst, which compresses the left hippocampus. Bruxism was documented by polysomnography, with extended electroencephalographic setup, without any electroencephalographic expression during episodes. Thus, we showed that the relation between bruxism and epilepsy in this patient with potentially epileptogenic lesion is remote.
How Much of the Clinical Predictability of Dangerousness Issue is Due to Language and Communication Difficulties?: Some Sample Courtroom Questions and Some Inspired but Heady Answers

If the golfer hits many golf balls but always in a dense fog so that he does not know how the shots really turn out, and therefore, he has no opportunity for making such corrections as might be necessary, it is unlikely that the fact that he has hit several golf balls, under such circumstances, will result in improving his game. Similarly, when a psychiatrist makes many diagnostic evaluations but lacks the opportu nity or fails to follow up his diagnostic conclusions to determine whether or not they were, in fact, and by objective indices, correct, his diagnostic accuracy is not likely to improve (Ziskin, 1975, p. 216).
Identification of an Octamer‐1 Transcription Factor Binding Site in the Promoter of the Mouse μ‐Opioid Receptor Gene

Abstract: In a previous study we showed that a region from −182 to +10 bp in the mouse μ‐opioid receptor (MOR) promoter exhibited strong promoter activity. To identify protein‐DNA interactions in this fragment, gel shift and DNase I footprint analyses were performed using nuclear extracts from mouse brain and the human neuroblastoma cell line, SK‐N‐SH. Two regions, nucleotide (nt) −121 to −100 and nt −42 to −22, were identified as being specific protein binding sites. The protein‐DNA interaction in the nt −42 to −22 region was characterized in detail in this study. Methylation interference analysis of this region showed that nuclear protein from SK‐N‐SH cells contacted nucleotides within the sequence ATG‐CAAAT, which is a binding motif for octamer trans‐acting factors. An octamer‐1 (Oct‐1)‐specific antibody supershifted the protein‐DNA complex in a gel shift assay. A UV cross‐linking experiment showed that a nuclear protein, whose molecular weight is similar to that of the Oct‐1 factor, bound to the octamer element in the nt −42 to −22 region. Mutagenesis of four base pairs within the octamer cis‐acting element eliminated the specific protein binding in vitro. When the MOR‐luciferase reporter construct (−182 to +10 bp) with the same four base pairs mutated was transiently transfected into SK‐N‐SH cells, a 200% increase in transcriptional activity was observed. Collectively, these data suggest that Oct‐1 is binding to the octamer motif in the MOR gene and negatively modulating MOR gene expression.
Global library innovative system: An image-search facilitated library system

From time immemorial, Libraries have been the house of Illuminati. With the advancing world, new discoveries are being made creating new horizons of knowledge and with new and increasing researches being made there has been a proliferation of books, journals and transcripts. With this surplus production of books and journals in both existing and new areas managing them in library has become a tedious task. Looking up for a book seems like searching for a needle in a haystack. In this age of digitalization and automation we present an automated and innovative library management system which will not only automate the management process but will also ease the manual searching of books. The emphasis is on using the techniques of Optical Character Recognition to obtain a resulting system which can identify and locate books in a physical library by the use of searching algorithms.
Euskara, hizkuntza ergatiboa ote da?

1.1. Azken aldiotan behin baino gehiagotan entzun ahal izan dugun galdera da hori. Eta galdera honek ez du, ez, erantzun erraza, beste hainbat eta hainbat galdera eta koropiloekin baitago erlazionatua. Goazen, hortaz, pixkanaka. Hizkuntzalariek esan ohi dute, oro har, hizkuntza bat ergatibotzat hartzen dela hizkuntza horretako perpaus iragangaitzen subjetua eta perpaus iragankorren objetua kasu berean agertzen badira. Euskararen datuak ikusirik, badirudi euskara ergatiboa dela: (1) Peru etorri da (2) Mikelek Peru agurtu du Ohart gaitezkeenez, hor ongi aski betetzen da hizkuntzen ergatibotasuna definitzeko erabiltzen den irizpidea, (1) adibideko perpaus iragangaitzaren subjetua eta (2) adibideko perpaus iragankorraren objetua kasu berean baitaude, bak absolutuan. Hortaz, itxuraz bederen, euskara ergatiboa dela erantzun genezake. 1.2. Hala ere, berehala ikusiko dugunez, gauzak ez dira hain sinpleak. Hasteko, perpausen iragankortasuna eta perpausen iragangaiztasuna normalean nola definitzen diren ikusi behar dugu. Hori batetik. Bestetik, ergatibitatearen kontua ez da bakarrik izen sintagmen morfologiara mugatzen (eman ditugun bi adibideak izen sintagmaren morfologiaren mailakoak dira) eta aditzaren morfologian edo sintaxian ere zer gertatzen den aztertu behar da, suerta bailiteke hizkuntza batzuk ergatiboak izatea morfologia mailan baina ez, ordea, sintaxian. Edo alderantziz. Azkenik, hizkuntza bat ergatiboa dela baldin badiogu ere, horrek ez du esan nahi ergatibitate hori beti eta egitura guztietan betetzen denik, egitura zenbaitetan ergatibitatea hautsa gertatzen baita. Ikus ditzagun puntu hauek banan-bana.