Miracle-dz/UniFAR-FTUs huggingface dataset:
PICNICS, PETS, AND PLEASANT PLACES: THE DISTINGUISHING CHARACTERISTICS OF LEISURE TRAVEL DEMAND. IN: SOCIAL CHANGE AND SUSTAINABLE TRANSPORT

This paper has three goals: to highlight the significant contribution of leisure travel to current patterns of travel; to present the hypothesis that the distinct characteristics of "discretionary" travel warrant a radically different understanding of the factors influencing this behavior; and to argue the need for new approaches to data collection. This research has determined that in any given population, and whatever the organizational setting, a variety of market segments exist that are likely to respond in different ways to different transport policies.
TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1

Limitation of excessive inflammation due to selective degradation of pro-inflammatory proteins is one of the cytoprotective functions attributed to autophagy. In the current study, we highlight that selective autophagy also plays a vital role in promoting the establishment of a robust inflammatory response. Under inflammatory conditions, here TLR3-activation by poly(I:C) treatment, the inflammation repressor TNIP1 (TNFAIP3 interacting protein 1) is phosphorylated by TBK1 (Tank-binding kinase 1) activating a LIR motif that leads to the selective autophagy-dependent degradation of TNIP1, supporting expression of pro-inflammatory genes and proteins. Thus, similarly as in cancer, autophagy may play a dual role in controlling inflammation depending on the exact state and timing of the inflammatory response. Summary Autophagy is well known for its anti-inflammatory effects. Here, we highlight that selective, autophagy-dependent degradation of the inflammation repressor TNIP1 supports pro-inflammatory gene and protein expression. Similarly as in cancer, autophagy appears to play a dual role in controlling inflammation.
The role of E2F2 in signaling pathways associated with cancer pathogenesis and potential treatment: A review of current studies

Introduction and objective. E2F transcription factor 2 (E2F2) protein is the transcription factor that plays an important role in tumorigenesis. E2F2 effects the cell cycle, tumor suppressor proteins, and can also be transformed by proteins of small DNA tumor viruses. The objective of the study is to provide a summary of the current knowledge on the neoplastic pathways that involve E2F2. State of knowledge. Numerous studies have demonstrated a role for E2F2 in various signaling pathways. Certain components of these pathways may serve as potential targets for oncological therapy. E2F2 has been shown to be associated with neoplasms of various locations and histological types (breast, colon, gastric, laryngeal, liver, lung, ovarian, pancreatic, and prostate cancers). Conclusions. Further investigations of E2F2 pathways are warranted for a clearer understanding of neoplastic processes and to identify novel pharmacological treatments.
Regional Employment Growth, Shocks and Regional Industrial Resilience: A Quantitative Analysis of the Danish ICT Sector

Holm J. R. and Østergaard C. R. Regional employment growth, shocks and regional industrial resilience: a quantitative analysis of the Danish ICT sector, Regional Studies. The resilience of regional industries to economic shocks has gained a lot of attention in evolutionary economic geography recently. This paper uses a novel quantitative approach to investigate the regional industrial resilience of the Danish information and communication technology (ICT) sector to the shock following the burst of the dot.com bubble. It is shown that regions characterized by small and young ICT service companies were more adaptable and grew more than others, while diversity and urbanization increased the sensitivity to the business cycle after the shock. Different types of resilient regions are found: adaptively resilient, rigidly resilient, entrepreneurially resilient and non-resilient regions.
Elaboration and characterization of Ni/BaTiO 3 Functionally Graded Piezoelectric Material for active vibration control applications

/BaTiO 3 FGPM pellet has been elaborated by the Spark Plasma Sintering technique (Dr Sinter-Lab SPS-515S, SPS Sintex Inc.). SPS sintering consists of heating the sample very quickly while applying a uniaxial charge. Thus, it is possible to densify the material in very short time thus limiting both grain growing and the interdiffusion of different chemical species. We propose to sinter together layers of mixture of ceramic powder/ metal with compositions ranging from 100% ceramic to 100% metal. Powders were sintered in a 15 mm diameter graphite die with a constant applied pressure of 100 MPa. The heating rate was fixed to 50°C.min -1 . The cooling rate was around 100°C.min -1 .
Load-Displacement Relations for an Edge-Cracked Beam with a Hysteretic Bilinear Cohesive Zone Model

Using vibration characteristics to detect damage in a structure is a class of nondestructive evaluation (NDE) that is gaining popularity. The effect of cohesive zones at crack tips, and their hysteretic behavior under cyclic loading, on the vibration response of cracked structures is an important research problem in NDE. The present work attempts to establish a methodology to obtain non-linear load-displacement curves at the crack plane of a damaged structure using a hysteretic cohesive zone model. The methodology is outlined by considering an edge-cracked, quasi-brittle Euler-Bernoulli beam under cyclic loading. The cohesive zone traction-displacement laws used are a bilinear softening law for loading, an irreversible linear unloading law towards zero traction-displacement state, and a hysteretic exponential reloading law back up to the bilinear law envelope. The beam is analyzed using a direct boundary element formulation and a cyclic triangular load profile. The load-displacement curves obtained here can be used as direct inputs in vibration analysis problems as boundary conditions.
PRODUCCIÓN DE BIODIESEL A PARTIR DE MICROALGAS: PARÁMETROS DEL CULTIVO QUE AFECTAN LA PRODUCCIÓN DE LÍPIDOS

Las microalgas poseen la capacidad para mitigar las emisiones de CO 2 y producir lipidos, por lo que se consideran con potencial para la obtencion de biocombustibles de tercera generacion. La presente revision proporciona informacion actualizada de la influencia de las condiciones de cultivo, sobre la obtencion de lipidos con una productividad elevada y perfil adecuado para la produccion de biodiesel, se proporciona una sintesis de resultados de investigaciones realizadas en los ultimos 13 anos en diversas partes del mundo. En la literatura consultada, los autores concluyen que aunque el comportamiento de las microalgas ante condiciones de estres fisiologico es variable entre especies; la limitacion de nutrientes especialmente nitrogeno y fosforo, asociado al crecimiento heterotrofico o a altas intensidades luminosas en fototrofia se consideran como las estrategias mas eficientes para incrementar el contenido de lipidos en las microalgas, en particular de trigliceridos constituidos por acidos grasos saturados y monoinsaturados, ideales para la produccion de biodiesel. De igual forma, senalan que la presencia de pequenas cantidades de CO 2 y la cosecha de la biomasa en la fase estacionaria de crecimiento, incrementan el contenido de lipidos y disminuyen el numero de insaturaciones de los acidos grasos que lo conforman.
New NMR investigation of [RuF 5 NO] 2 (cid:1) anion

The 15 N shift value is the main distinctive parameter to distinguish linear than angular MNO in transition metal nitrosyls by NMR spectroscopy. To get insight into the spectroscopic properties of a simple ruthe-nium-nitrosyl complex, the [RuF 5 NO] 2 (cid:1) anion, was reinvestigated. Their 15 N and 19 F nuclear magnetic resonance spectra (NMR) were analyzed and compared with the behavior observed for the geometrically related (C 4v ) [Fe(CN) 5 NO] 2 (cid:1) ( 15 N and 13 C enriched) ion. The different splitting and coupling constants observed in both systems were attributed to the small change in angles and atomic distances. These results highlight the sensitivity of this spectroscopy to detect small geometrical distortion in transition metal complexes. DFT calculations predicted for both systems, shifts and coupling constant values in good agreement with the experimental results. The chemical shifts and coupling constants parameters predicted by DFT calculations for both systems are in good agreement with experimental values.
A graphical derivation and statistical evaluation of simplified polynomials to determine vapour pressure deficit for use in ultra-low power microcontroller applications

The aim of this work has been to derive and statistically evaluate the accuracy of second-order and third-order polynomials to determine vapour pressure deficit (VPD). These polynomials take air temperature and relative humidity measurements to determine VPD without the use of an exponential function, as proposed by F W Murray in 1967. Replacing the exponential function with a 2nd or 3rd order polynomial may be beneficial in ultra-low power microcontroller-based measurement applications where; code size, memory usage and power requirements are critical design drivers. However, oversimplification may impact precision. This work presents alternative 2nd order and 3rd order equations that have been derived from a Murray equation dataset where VPD isothermal datasets were plotted against relative humidity. These linear relationships allow y = mx + c analysis where, (i) ‘c’ can be set to zero with a offset in the relative humidity data, and, (ii) ‘m’ can be derived from a 2nd of 3rd order polynomial where ‘m’ = f(T) and is derived using Excel-based fitting of the gradients from the isothermal datasets. The resulting ‘m’ = f(T) 2nd and 3rd order polynomials presented R 2 values of 0.998 04 and 0.999 98 respectively. A Bland-Altman statistical assessment was performed, where the Murray equation (reference) dataset is plotted against the difference between the reference and polynomial datasets using the same air temperature and relative humidity inputs. The difference datasets presented 2-sigma (95% confidence interval) variances for the 2nd and 3rd order polynomials as <±0.1 kPa and <±0.01 kPa respectively. The 2nd and 3rd order polynomials also resulted in a bias values of <0.0037 kPa and <0.0013 kPa respectively. These results suggest that a 3rd order polynomial equation could be used to determine VPD in ultra-low-power microcontroller measurement applications, with minimal impact on VPD measurement precision.
Aalborg Universitet Spontaneous emission in two-dimensional photonic crystal microcavities

The properties of the radiation field in a two-dimensional photonic crystal with and without a microcavity introduced are investigated through the concept of the position-dependent photon density of states. The position-dependent rate of spontaneous radiative decay for a two-level atom with random orientation is deduced from the photon density of states using the Fermi Golden Rule.
Watershed-Mediated Ecomorphological Variation: A Case Study with the Twin-Striped Clubtail Dragonfly (Hylogomphus geminatus)

Simple Summary Changes in the size of aquatic or amphibious organisms can signal environmental alterations. The Twin-striped Clubtail is a dragonfly in the southeastern US with known variation in total body length. Our objective was to characterize the significance and extent of size differences in the species and determine whether those differences are associated with watersheds across the species’ limited range. In this species, total body length varied by watershed. Significant differences in length were noted in many watershed comparisons, most notably in adjacent watersheds on either side of the Apalachicola River, FL, which differed in land-cover types; smaller individuals were associated with more disturbed forms of land cover. Our results suggest there are watershed-level differences in body length across the range of the species that should be examined more closely with respect to different potential environmental stressors, such as poor water quality from changing land cover associated with agriculture and urbanization. Abstract Anthropogenic land-cover change is modifying ecosystems at an accelerating rate. Changes to ecomorphologically variable taxa within those ecosystems serve as early-warning signs that resources on which humans and other animals depend are being altered. One known ecomorphologically variable taxon is Hylogomphus geminatus, a species of dragonfly in the southeastern United States that shows pronounced variation in total body length across its limited geographic range. We measured total length of live as well as preserved museum specimens of H. geminatus and the sympatric species Progomphus obscurus (as a means for comparison). Both species showed significant size differences linked to HUC-8 watersheds in which they occur. H. geminatus showed additional significant differences on either side of the Apalachicola River, Florida, for all comparisons by sex. In overlapping watersheds, the species tended to show the same trends in length relative to their respective averages. Smaller body length was associated with more urban and agricultural land cover. These findings indicate that ecomorphological variation is tied to the watershed scale and point to significant variations on either side of the Apalachicola River. More thorough future analyses would be needed to verify trends in body length and identify the drivers behind them.
Axiomatizations of the Shapley value for games on antimatroids

AbstractGames onantimatroids are cooperative games restricted by a combinatorialstructure which generalize thepermission structure. So, cooperative games onantimatroids group several well-known families of games which have importantapplications in economic and politic. Therefore, the study of the rectrictedgames by antimatroids allows to unify criteria of various lines of research. Thecurrent paper establishes axioms that determine the restrictedShapley valueon antimatroids by conditions on the cooperative gamev and the structuredetermined by the antimatroid. This axiomatization generalizes the axioma-tizations of both the conjunctive and disjunctive permission value for gameswith a permission structure. We also provide an axiomatization of the Shapleyvalue restricted to the smaller class of poset antimatroids . Mathematics Subject Classi…cation 2000: 91A12Key words: Antimatroid, permission structure, Shapley value. 1Introduction Acooperativegamedescribesasituationinwhicha…nitesetofplayersN can gen-erate certain payo¤s by cooperation. In a cooperative game the players are assumedto be socially identical in the sense that every player can cooperate with every otherplayer. However, in practice there exist social asymmetries among the players. Forthis reason, the game theoretic analysis of decision processes in which one imposesasymmetric constraints on the behavior of the players has been and continues tobe an important subject to make a study. So, important consequences have beenobtained of adopting this type of restrictions on economic behavior. Some modelswhich analyze social asymmetries among players in a cooperative game are describedin, e.g., Myerson (1977), Owen (1986) and Borm, Owen, and Tijs (1992). In thesemodels the possibilities of coalition formation are determined by the positions of theplayers in a communication graph . Another type of asymmetry among the players ina cooperative game is introducedin Gilles, Owen and van den Brink (1992), Gilles and Owen (1999), van den Brink andGilles (1996) and van den Brink (1997). In these models, the possibilities of coalition
Seismic damage in historic town centres and attenuation criteria

The structural significance of the damage scenarios characteristic of VIII and IX degrees on the MKS macroseismic scale is discussed with reference to the seismic behaviour of the buildings which make up the urban fabric of a historic town or city. In an VIII degree scenario, damage is limited to structurally precarious situations, while a IX degree scenario involves seismic damage to external walls. Mechanical interpretation of these scenarios provides the basis for intervention strategies sufficiently well defined as to constitute a guide for seismic damage prevention programmes. VIII degree damage is prevented by identifying precarious situations. while IX degree damage requires systematic action. A proposal is put forward for the clarification of seismic regulations and the usefulness of evaluating future earthquakes in macroseismic terms with reference to the safety requirements of new buildings is discussed.
Development of Quinazolinone Derivatives as Modulators of Virulence Factors of Pseudomonas aeruginosa Cystic Fibrosis Strains

Pseudomonas aeruginosa (PA), one of the ESKAPE pathogens, is an opportunistic Gram-negative bacterium responsible for nosocomial infections in humans but also for infections in patients affected by AIDS, cancer, or cystic fibrosis (CF). Treatment of PA infections in CF patients is a global healthcare problem due to the ability of PA to gain antibiotic tolerance through biofilm formation. Anti-virulence compounds represent a promising approach as adjuvant therapy, which could reduce or eliminate the pathogenicity of PA without impacting its growth. Pyocyanin is one of the virulence factors whose production is modulated by the Pseudomonas quinolone signal (PQS) through its receptor PqsR. Different PqsR modulators have been synthesized over the years, highlighting this new powerful therapeutic strategy. Based on the promising structure of quinazolin-4(3H)-one, we developed compounds 7a–d, 8a,b, 9, 10, and 11a–f able to reduce biofilm formation and the production of virulence factors (pyocyanin and pyoverdine) at 50 µM in two PA strains responsible for CF acute and chronic infections. The developed compounds did not reduce the cell viability of IB3-1 bronchial CF cells, and computational studies confirmed the potential ability of novel compounds to act as potential Pqs system modulators.
Caregiver Burden and Quality of Life of Caregivers for Patients with Parkinson’s Disease Treated with Deep Brain Stimulation

Objective: This study aimed to identify caregiver burden (CB) and contributing factors to CB for Parkinson's disease (PD) patients under Subthalamic Nucleus Deep Brain Stimulation (STN-DBS) treatment, and investigation the factors, affecting the caregivers' quality of life (QoL). Methods: Twenty-four PD patients under STN-DBS treatment and their caregivers participated in this study. Unified Parkinson's Disease Rating Scale (UPDRS) was applied for the clinical assessment of the patients. Beck Depression Inventory-II (BDI), Hospital Anxiety and Depression Scale (HADS), and Minnesota Impulse Control Disorders Interview (MIDI) were used to screen for neuropsychiatric symptoms of the patients. CB was evaluated with the Caregivers Burden Inventory (CBI) and the Burden Scale for Family Caregivers (BSFC-s). The health-related QoL of caregivers was assessed with the Short Form Survey-36 (SF-36). Results: Mean total CBI and BSFC-s scores of caregivers were 32.53 ± 19.71 and 11.66 ± 8.86, respectively. Nineteen caregivers defined moderate or severe caregiver burden according to BSFC-s. Both CBI and BSFC-s scores were significantly associated with UPDRS-part-1 scores, but not with the age and gender of both the patients and their caregivers, disease duration, PDQ39, BDI, HADS, LARS scores, and scores of patients for other UPDRS parts. The presence of impulse control behaviors (ICBs) significantly increased the total CBI score and total BSFC-s (P < 0.01). The caregivers' total and all domain scores of SF-36 were significantly affected by higher CBI and BSFC-s scores. Conclusions: The CB of the patients under STN-DBS treatment was severe. Non-motor symptoms, particularly impulsivity, significantly increased CB and worsened the caregivers' mental and physical health.
Roots of the Industrial Revolution

We analyze factors explaining the very different patterns of industrialization across the 42 counties of England between 1760 and 1830. Against the widespread view that high wages and cheap coal drove industrialization, we find that industrialization was restricted to low wage areas, while energy availability (coal or water) had little impact Instead we find that industrialization can largely be explained by two factors related to the human capability of the labour force. Instead of being composed of landless labourers, successful industrializers had large numbers of small farms, which are associated with better nutrition and height. Secondly, industrializing counties had a high density of population relative to agricultural land, indicating extensive rural industrial activity: counties that were already reliant on small scale industry, with the technical and entrepreneurial skills this generated, experienced the strongest industrial growth. Looking at 1830s France we find that the strongest predictor of industrialization again is quality of workers shown by height of the population, although market access and availability of water power were also important.
A Termination Analyser for Java Bytecode Based on Path-Length

It is important to prove that supposedly terminating programs actually terminate, particularly if those programs must be run on critical systems or downloaded into a client such as a mobile phone. Although termination of computer programs is generally undecidable, it is possible and useful to prove termination of a large, nontrivial subset of the terminating programs. In this paper we present our termination analyser for sequential Java bytecode, based on a program property called path-length. We describe the analyses which are needed before the path-length can be computed, such as sharing, cyclicity and aliasing. Then we formally define the path-length analysis and prove it correct w.r. t. a reference denotational semantics of the bytecode. We show that a constraint logic program PCLP can be built from the result of the path-length analysis of a Java bytecode program P and formally prove that if PCLP terminates then also P terminates. Hence a termination prover for constraint logic programs can be applied to prove the termination of P . We conclude with some discussion of the possibilities and limitations of our approach. Ours is the first existing termination analyser for Java bytecode dealing with generic data structures dynamically allocated on the heap and which does not require any help or annotation on the part of the user.
Cyber Diplomacy and Artificial Intelligence: Opportunities and Challenges

The application of AI in cyber diplomacy offers promising prospects for enhancing international cybersecurity efforts. AI can analyze extensive data sets and uncover patterns that may indicate cyber threats. This can equip governments and organizations with a deeper understanding of the nature and scope of cyber threats, thereby facilitating more effective responses. Additionally, AI can enable the creation of automated threat detection and response systems, thereby reducing response times and improving the overall efficacy of cybersecurity measures. Furthermore, AI can facilitate the development of predictive models that can anticipate potential cyber threats before they materialize, further enhancing the ability to address cybersecurity challenges