Miracle-dz/UniFAR-FTUs huggingface dataset:
Association Between Obesity and Chronic Kidney Disease, Defined by Both Glomerular Filtration Rate and Albuminuria, in Korean Adults.

BACKGROUND Chronic kidney disease (CKD) has often been defined based on glomerular filtration rate (GFR) alone. The Kidney Disease: Improving Global Outcomes guideline highlights albuminuria in the CKD definition. Thus, we investigated the association between obesity and CKD, as defined by both GFR and albuminuria, in Korean adults. METHODS We used Korea National Health and Nutrition Examination Survey 2011-2014 data (N = 19,331, ≥19 years old) representing the national Korean population. CKD was classified by (1) estimated GFR (eGFR) < 60 mL/min/1.73 m2 (CKDGFR); (2) albumin-to-creatinine ratio (ACR) ≥30 mg/gram (CKDACR); and (3) eGFR < 60 mL/min/1.73 m2 or ACR ≥30 mg/gram (CKDRisk). Associations between obesity and each CKD category were evaluated using multivariate logistic regression analysis. RESULTS The prevalence rates of CKDGFR, CKDACR, and CKDRisk were 2.2%, 6.7%, and 8.1%, respectively. Compared with the normal body mass index (BMI; 18.5-22.9 kg/m2) group, men with BMI ≥ 25 kg/m2 had 1.88 times greater risk of CKDGFR in the adjusted model [95% confidence interval (CI), 1.26-2.80; P = 0.002]; BMI was not significantly associated with CKDGFR in women. In contrast, both men and women with BMI ≥ 25 kg/m2 had 1.58 and 1.40 times higher risk of CKDACR (95% CI, 1.21-2.07 and 1.08-1.81, respectively, both P < 0.01). Obese men and women had 1.65 and 1.38 times higher risk of CKDRisk (95% CI, 1.29-2.12 and 1.09-1.75, respectively, both P < 0.01). CONCLUSIONS Obesity was significantly associated with an increased ACR-based CKD risk. Longitudinal studies are needed to investigate the role of overweight and obesity in the development and progression of CKD.
Icon scanning: Towards next generation QR codes

Undoubtedly, a key feature in the popularity of smartmobile devices is the numerous applications one can install. Frequently, we learn about an application we desire by seeing it on a review site, someone else's device, or a magazine. A user-friendly way to obtain this particular application could be by taking a snapshot of its corresponding icon and being directed automatically to its download link. Such a solution exists today for QR codes, which can be thought of as icons with a binary pattern. In this paper we extend this to App-icons and propose a complete system for automatic icon-scanning: it first detects the icon in a snapshot and then recognizes it. Icon scanning is a highly challenging problem due to the large variety of icons (~500K in App-Store) and background wallpapers. In addition, our system should further deal with the challenges introduced by taking pictures of a screen. Nevertheless, the novel solution proposed in this paper provides high detection and recognition rates. We test our complete icon-scanning system on icon snapshots taken by independent users, and search them within the entire set of icons in App-Store. Our success rates are high and improve significantly on other methods.
Malrotation Causing Patellofemoral Complications After Total Knee Arthroplasty

Thirty patients with isolated patellofemoral complications after total knee arthroplasty were compared with 20 patients with well functioning total knee replacements without patellofemoral complications. The epicondylar axis and tibial tubercle were used as references on computed tomography scans to measure quantitatively rotational alignment of the femoral and tibial components. The group with patellofemoral complications had excessive combined (tibial plus femoral) internal component rotation. This excessive combined internal rotation was directly proportional to the severity of the patellofemoral complication. Small amounts of combined internal rotation (1°-4°) correlated with lateral tracking and patellar tilting. Moderate combined internal rotation (3°-8°) correlated with patellar subluxation. Large amounts of combined internal rotational (7°-17°) correlated with early patellar dislocation or late patellar prosthesis failure. The control group was in combined external rotation (10°-0°). The direct correlation of combined (femoral and tibial) internal component rotation to the severity of the patellofemoral complication suggests that internal component rotation may be the predominant cause of patellofemoral complications in patients with normal axial alignment. The epicondylar axis and tibial tubercle are reproducible landmarks which are visible on computed tomography scans and can be used intraoperatively. Using this computed tomography study can determine whether rotational malalignment is present and thus, whether revision of one or both components may be indicated.
Aberrant promoter hypermethylation and genomic hypomethylation in tumor, adjacent normal tissues and blood from breast cancer patients.

BACKGROUND Promoter hypermethylation and global hypomethylation in the human genome are hallmarks of most cancers. Detection of aberrant methylation in white blood cells (WBC) has been suggested as a marker for cancer development, but has not been extensively investigated. This study was carried out to determine whether aberrant methylation in WBC DNA can be used as a surrogate biomarker for breast cancer risk. PATIENTS AND METHODS Promoter hypermethylation of 8 tumor suppressor genes (RASSF1A, APC, HIN1, BRCA1, CYCLIND2, RARbeta, CDH1 and TWIST1) and DNA methylation for three repetitive elements (LINE1, Sat2 and Alu) were analyzed in invasive ductal carcinoma of the breast, paired adjacent normal tissue and WBC from 40 breast cancer patients by the MethyLight assay. Methylation in WBC from 40 controls was also analyzed. RESULTS Tumor and adjacent tissues showed frequent hypermethylation for all genes tested, while WBC DNA was rarely hypermethylated. For HIN1, RASSF1A, APC and TWIST1, there was agreement between hypermethylation in tumor and adjacent tissues (p=0.04, p=0.02, p=0.005 and p<0.0001, respectively). DNA methylation for the three repetitive elements was lower in tumor compared to adjacent tissue and WBC DNA. Significant correlations in the methylation of Sat2M1 between tumor and adjacent tissues and WBC DNA were found (p<0.0001 and p=0.046, respectively). There was also a significant difference in methylation of Sat2M1 between cases and controls (p=0.01). CONCLUSION These results suggest that further studies of WBC methylation, including prospective studies, may provide biomarkers of breast cancer risk.
Postmodern (narrative) career counselling and education

One of the challenges clearly arising for career educators and career counsellors at the beginning of the 21st century centres on "what our theory base should be" (Watson & Stead, 2002, 29). Career practice is culturally and historically located, and to date the tenets of modernism prevail as the dominant story in the field. Influenced by postmodern thought, stories of possibility about career practice in the 21st century are being constructed.
Problematic Substance Use Among Hispanic Adolescents and Young Adults: Implications for Prevention Efforts

Using data collected between 2005 and 2012 from a longitudinal study of acculturation patterns and substance use among Hispanic youth in Southern California (N = 2722), we fit multivariate logistic regression models to estimate the association of type and frequency of drug use, friend and parent drug use, cultural orientation (measured by the ARSMA-II), and psychological distress (CES-D score) in 10th grade with problematic substance use (measured with the RAPI) in (i) 11th grade and (ii) young adulthood. We conclude that future intervention efforts with Hispanic adolescents and young adults should target polysubstance and problem users and emphasize inter-individual, structural, and cultural processes as they relate to problematic substance use.
Potential Role of Nitrite for Abiotic Fe(II) Oxidation and Cell Encrustation during Nitrate Reduction by Denitrifying Bacteria

ABSTRACT Microorganisms have been observed to oxidize Fe(II) at neutral pH under anoxic and microoxic conditions. While most of the mixotrophic nitrate-reducing Fe(II)-oxidizing bacteria become encrusted with Fe(III)-rich minerals, photoautotrophic and microaerophilic Fe(II) oxidizers avoid cell encrustation. The Fe(II) oxidation mechanisms and the reasons for encrustation remain largely unresolved. Here we used cultivation-based methods and electron microscopy to compare two previously described nitrate-reducing Fe(II) oxidizers ( Acidovorax sp. strain BoFeN1 and Pseudogulbenkiania sp. strain 2002) and two heterotrophic nitrate reducers (Paracoccus denitrificans ATCC 19367 and P. denitrificans Pd 1222). All four strains oxidized ∼8 mM Fe(II) within 5 days in the presence of 5 mM acetate and accumulated nitrite (maximum concentrations of 0.8 to 1.0 mM) in the culture media. Iron(III) minerals, mainly goethite, formed and precipitated extracellularly in close proximity to the cell surface. Interestingly, mineral formation was also observed within the periplasm and cytoplasm; intracellular mineralization is expected to be physiologically disadvantageous, yet acetate consumption continued to be observed even at an advanced stage of Fe(II) oxidation. Extracellular polymeric substances (EPS) were detected by lectin staining with fluorescence microscopy, particularly in the presence of Fe(II), suggesting that EPS production is a response to Fe(II) toxicity or a strategy to decrease encrustation. Based on the data presented here, we propose a nitrite-driven, indirect mechanism of cell encrustation whereby nitrite forms during heterotrophic denitrification and abiotically oxidizes Fe(II). This work adds to the known assemblage of Fe(II)-oxidizing bacteria in nature and complicates our ability to delineate microbial Fe(II) oxidation in ancient microbes preserved as fossils in the geological record.
Non-wetting wings and legs of the cranefly aided by fine structures of the cuticle

Non-wetting surfaces are imperative to the survival of terrestrial and semi-aquatic insects as they afford resistance to wetting by rain and other liquid surfaces that insects may encounter. Thus, there is an evolutionary pay-off for these insects to adopt hydrophobic technologies, especially on contacting surfaces such as legs and wings. The cranefly is a weak flier, with many species typically found in wet/moist environments where they lay eggs. Water droplets placed on this insect's wings will spontaneously roll off the surface. In addition, the insect can stand on water bodies without its legs penetrating the water surface. The legs and wings of this insect possess thousands of tiny hairs with intricate surface topographies comprising a series of ridges running longitudinally along the long axis of the hair fibre. Here we demonstrate that this fine hair structure enhances the ability of the hairs to resist penetration into water bodies.
C57BL/6J and DBA/2J mice vary in lick rate and ingestive microstructure

Fluid licking in mice is an example of a rhythmic behavior thought to be under the control of a central pattern generator. Inbred strains of mice have been shown to differ in mean or modal interlick interval (ILI) duration, suggesting a genetic‐based variation. We investigated water licking in the commonly used inbred strains C57BL/6J (B6) and DBA/2J (D2), using a commercially available contact lickometer. Results from 20‐min test sessions indicated that D2 mice lick at a faster rate than B6 mice (10.6 licks/s vs. 8.5 licks/s), based on analysis of the distribution of short‐duration ILIs (50–160 ms). This strain difference was independent of sex, extent of water deprivation or total number of licks. D2 mice also displayed a faster lick rate when the strains were tested with a series of brief (5 s) trials. However, when ingestion over the entire 20‐min session was analyzed, it was evident that D2 mice had an overall slower rate of ingestion than B6 mice. This was because of the tendency for D2 mice to have more very long pauses (>30 s) between sequences of licking bursts. Overall, it appeared that D2 mice licked more efficiently, ingesting more rapidly during excursions to the spout that were fewer and farther between.
ReFlexIn: A Flexible Receptor Protein-Ligand Docking Scheme Evaluated on HIV-1 Protease

For many targets of pharmaceutical importance conformational changes of the receptor protein are relevant during the ligand binding process. A new docking approach, ReFlexIn (Receptor Flexibility by Interpolation), that combines receptor flexibility with the computationally efficient potential grid representation of receptor molecules has been evaluated on the retroviral HIV-1 (Human Immunodeficiency Virus 1) protease system. An approximate inclusion of receptor flexibility is achieved by using interpolation between grid representations of individual receptor conformations. For the retroviral protease the method was tested on an ensemble of protease structures crystallized in the presence of different ligands and on a set of structures obtained from morphing between the unbound and a ligand-bound protease structure. Docking was performed on ligands known to bind to the protease and several non-binders. For the binders the ReFlexIn method yielded in almost all cases ligand placements in similar or closer agreement with experiment than docking to any of the ensemble members without degrading the discrimination with respect to non-binders. The improved docking performance compared to docking to rigid receptors allows for systematic virtual screening applications at very small additional computational cost.
Changing Trends of Vulvovaginal Candidiasis

Introduction: Vulvovaginal candidiasis is one of the most common infections seen in women. Materials and Methods: A total of 300 symptomatic women were studied. High vaginal swabs collected from each patient were processed by Gram stain, culture on Sabourauds dextrose agar and CHROM agar plates. Isolates were identified and speciated using conventional methods and by the color of the colonies on the CHROM agar. Antifungal susceptibility was performed by disc diffusion method for fluconazole (25 μg) and voriconazole (1 μg) discs as per Clinical and Laboratory Standards Institute (CLSI) guidelines. Results: Vulvovaginal candidiasis was found in 53 (17.7%) of cases. Gram stain was positive in 22 (41.41%) of culture positives. Speciation of isolates by conventional and CHROM agar methods showed similar results. C. albicans 35 (66.0%) was the most common species isolated followed by C. tropicalis 14 (26.4%), C. krusei 2 (3.8%), C. parapsilosis and C. glabrata in 1 (1.9%) case each. Sensitivity to fluconazole was found in 91.4% of C. albicans, 57.1% of C. tropicalis and 50.0% of C. krusei. Sensitivity to voriconazole was seen in 91.4% of C. albicans, 85.7% of C. tropicalis and 50.0% of C. krusei. C. parapsilosis and C. glabrata were found sensitive only to voriconazole. Conclusion: CHROM agar has the advantage of being rapid, simple and cost effective method as compared to conventional methods in speciation of Candida. Routine susceptibility testing of Candida isolates help in selecting the most appropriate antifungal agent for vulvovaginal candidiasis.
DYNAMICAL EVOLUTION OF MULTI-RESONANT SYSTEMS: THE CASE OF GJ 876

The GJ 876 system was among the earliest multi-planetary detections outside of the Solar System, and has long been known to harbor a resonant pair of giant planets. Subsequent characterization of the system revealed the presence of an additional Neptune mass object on an external orbit, locked in a three body Laplace mean motion resonance with the previously known planets. While this system is currently the only known extrasolar example of a Laplace resonance, it differs from the Galilean satellites in that the orbital motion of the planets is known to be chaotic. In this work, we present a simple perturbative model that illuminates the origins of stochasticity inherent to this system and derive analytic estimates of the Lyapunov time as well as the chaotic diffusion coefficient. We then address the formation of the multi-resonant structure within a protoplanetary disk and show that modest turbulent forcing in addition to dissipative effects is required to reproduce the observed chaotic configuration. Accordingly, this work places important constraints on the typical formation environments of planetary systems and informs the attributes of representative orbital architectures that arise from extended disk-driven evolution.
Network Slicing Games: Enabling Customization in Multi-Tenant Mobile Networks

Network slicing to enable resource sharing among multiple tenants–network operators and/or services–is considered as a key functionality for next generation mobile networks. This paper provides an analysis of a well-known model for resource sharing, the share-constrained proportional allocation mechanism, to realize network slicing. This mechanism enables tenants to reap the performance benefits of sharing, while retaining the ability to customize their own users’ allocation. This results in a network slicing game in which each tenant reacts to the user allocations of the other tenants so as to maximize its own utility. We show that, for elastic traffic, the game associated with such strategic behavior converges to a Nash equilibrium. At the Nash equilibrium, a tenant always achieves the same or better performance than that of a static partitioning of resources, thus providing the same level of protection as static partitioning. We further analyze the efficiency and fairness of the resulting allocations, providing tight bounds for the price of anarchy and envy-freeness. Our analysis and extensive simulation results confirm that the mechanism provides a comprehensive practical solution to realize network slicing. Our theoretical results also fills a gap in the analysis of this resource allocation model under strategic players.
Utilization of IP streaming in identification of the speaker

In this paper, the research on the identification of a person in the video broadcast through the IP stream is presented. The software solution is created based on the analysis of face detection methods and current related researches. The crucial part is the identification of individual (university staff) in the IP stream. Training is carried out prior to the identification process. The software solution in form of the web application is created to enable live streaming. It further promotes the functionalities of discussion and voting on questions. System administrator interface is created to allow control over person identification and management of questions. Another essential part focuses on the processing and storing data from discussion or voting. The research verifies the reliability of identified persons through the series of experimental tests.
Situational Tests in Student Selection: An Examination of Predictive Validity, Adverse Impact, and Construct Validity

The Flemish Admission Exam ‘Medical and Dental Studies’ is comprised of four cognitive ability tests and four situational tests, namely two work samples (i.e., a lecture and a medical text) and two video-based situational judgement tests (i.e., a physician‐patient interaction and a medical expert discussion). On the basis of the Admission Exam scores of 941 candidates (359 men, 582 women) this study shows that situational tests significantly can predict better than cognitive ability tests, with lecture and text emerging as significant predictors. When situational tests are combined with cognitive ability tests, there are no mean gender differences. Situational tests also enable us to measure a broader range of constructs. For example, in this study, the personality factor Openness is related to better situational test performance. Overall, this study demonstrates that situational tests may be a useful complement to traditional student selection procedures.
Semantic Role Labeling via Consensus in Pattern-Matching

A cathode for use in the electrolytic refining of copper which comprises a carrying bar and a flat starting plate, which is secured to the carrying bar and made of special steel and provided with electrically insulating edge strips at least at its vertical longitudinal edges, which are formed in their edge faces with a groove, which contains an edge strip, that is made of a natural or synthetic polymer and fits into said groove and protrudes from the edge throughout its length. To prevent a deposition of metal in the critical region, the insulating edge strip which has been fitted into the dovetail groove has been formed by a longitudinal folding of a polymer film and contains at its fold line a wire of special steel, and the side portions of said film are coextensive and lie one over the other and are liquid-tightly joined to each other. The invention relates also to a process of manufacturing the cathode.
Lessons from teachers on performing HRI studies with young children in schools

We deployed an autonomous social robotic learning companion in three preschool classrooms at an American public school for two months. Before and after this deployment, we asked the teachers and teaching assistants who worked in the classrooms about their views on the use of social robots in preschool education. We found that teachers' expectations about the experience of having a robot in their classrooms often did not match up with their actual experience. These teachers generally expected the robot to be disruptive, but found that it was not, and furthermore, had numerous positive ideas about the robot's potential as a new educational tool for their classrooms. Based on these interviews, we provide a summary of lessons we learned about running child-robot interaction studies in preschools. We share some advice for future researchers who may wish to engage teachers and schools in the course of their own human-robot interaction work. Understanding the teachers, the classroom environment, and the constraints involved is especially important for microgenetic and longitudinal studies, which require more of the school's time-as well as more of the researchers' time-and is a greater opportunity investment for everyone involved.
Techniques for Interactive Ray Tracing of Bézier Surfaces

We present a simple and generic algorithm for interactive ray tracing of free-form surfaces, allowing for a simple implementation for bicubic Bézier surfaces. The algorithm uses a fixed number of on-the-fly refinement steps to prevent crack appearance. Furthermore, we show that grouping rays into coherent bundles and tracing them together achieves a speed-up factor of more than 5 compared to tracing only single rays. Combining ray-bundle-based ray tracing with optimized kd-tree construction even allows for interactively ray tracing completely dynamic scenes with thousands of patches. Even highly complex scenes consisting of a million Bézier patches can be interactively ray traced while requiring only a few seconds startup time. Source code is available online.