Miracle-dz/UniFAR-FTUs huggingface dataset:
Transcriptomic analysis reveals the lipid metabolism-related gene regulatory characteristics and potential therapeutic agents for myocardial ischemia-reperfusion injury

Background Impaired energy balance caused by lipid metabolism dysregulation is an essential mechanism of myocardial ischemia-reperfusion injury (MI/RI). This study aims to explore the lipid metabolism-related gene (LMRG) expression patterns in MI/RI and to find potential therapeutic agents. Methods Differential expression analysis was performed to screen the differentially expressed genes (DEGs) and LMRGs in the MI/RI-related dataset GSE61592. Enrichment and protein-protein interaction (PPI) analyses were performed to identify the key signaling pathways and genes. The expression trends of key LMRGs were validated by external datasets GSE160516 and GSE4105. The corresponding online databases predicted miRNAs, transcription factors (TFs), and potential therapeutic agents targeting key LMRGs. Finally, the identified LMRGs were confirmed in the H9C2 cell hypoxia-reoxygenation (H/R) model and the mouse MI/RI model. Results Enrichment analysis suggested that the “lipid metabolic process” was one of the critical pathways in MI/RI. Further differential expression analysis and PPI analysis identified 120 differentially expressed LMRGs and 15 key LMRGs. 126 miRNAs, 55 TFs, and 51 therapeutic agents were identified targeting these key LMRGs. Lastly, the expression trends of Acadm, Acadvl, and Suclg1 were confirmed by the external datasets, the H/R model and the MI/RI model. Conclusion Acadm, Acadvl, and Suclg1 may be the key genes involved in the MI/RI-related lipid metabolism dysregulation; and acting upon these factors may serve as a potential therapeutic strategy.
Hydrological modelling of urban catchments under climate change for the design of a spatial decision support system to mitigate flooding using pervious pavements meeting the principles of sustainability

First of all, I want to express my gratitude to the Spanish Ministry of Economy and Com-petitiveness for financing my doctoral studies through the research project “Hydrological Rehabilitation of Urban Road Infrastructures (RHIVU)” (Ref. BIA2012-32463). I would also like to extend my sincere appreciation to all the entities that provided the data nec-essary to develop this thesis: Helsinki Region Environmental Services Authority (HSY), Map Service of Espoo, National Land Survey of Finland, Geological Survey of Finland, EURO-CORDEX and European Climate Assessment & Dataset.
Rhyolite and Trachyte Formation at Lake City Caldera: Insight from Quantitative Textural and Geochemical Analyses

7 1) Introduction . 8 1.1 Zoned ignimbrites . 9 2) Geologic background . 9 2.1 Sunshine Peak Tuff . 10 2.2 Resurgent Intrusive Unit . 10 3) Methods . 10 3.1 Petrography . 10 3.2 iSpectra . 11 3.3 Crystal Size Distributions . 11 3.4 Microprobe . 12 3.5 Cathodoluminescence . 12 3.6 Laser Ablation . 12 4) Results. 13 4.1 Petrography . 13 4.1.1 LSPT, MSPT, rhyolite . 13 4.1. 2 USPT trachyte . 13 4.1. 3 Syenite . 14 4.1. 4 Mafic Enclaves . 15 4.1. 5 Alteration . 16 4.2 Quantitative textural analysis . 17 4.2.1 Crystal size distributions (CSDs) . 17 4.3 Cathodoluminescence (CL) imaging . 19 4.4 Mineral chemistry . 21 4.4.1 Potassium feldspar . 21 4.4.2 Plagioclase . 23 4.4.3 Quartz . 24 4.4.4 Biotite. 26 4.4. 5 Fe-Ti oxides . 29 4.6 Geothermometry . 29
The Inhibition Effect of Epigallocatechin-3-Gallate on the Co-Aggregation of Amyloid-β and Human Islet Amyloid Polypeptide Revealed by Replica Exchange Molecular Dynamics Simulations

Alzheimer’s disease and Type 2 diabetes are two epidemiologically linked diseases which are closely associated with the misfolding and aggregation of amyloid proteins amyloid-β (Aβ) and human islet amyloid polypeptide (hIAPP), respectively. The co-aggregation of the two amyloid proteins is regarded as the fundamental molecular mechanism underlying their pathological association. The green tea extract epigallocatechin-3-gallate (EGCG) has been extensively demonstrated to inhibit the amyloid aggregation of Aβ and hIAPP proteins. However, its potential role in amyloid co-aggregation has not been thoroughly investigated. In this study, we employed the enhanced-sampling replica exchange molecular dynamics simulation (REMD) method to investigate the effect of EGCG on the co-aggregation of Aβ and hIAPP. We found that EGCG molecules substantially diminish the β-sheet structures within the amyloid core regions of Aβ and hIAPP in their co-aggregates. Through hydrogen-bond, π–π and cation–π interactions targeting polar and aromatic residues of Aβ and hIAPP, EGCG effectively attenuates both inter-chain and intra-chain interactions within the co-aggregates. All these findings indicated that EGCG can effectively inhibit the co-aggregation of Aβ and hIAPP. Our study expands the potential applications of EGCG as an anti-amyloidosis agent and provides therapeutic options for the pathological association of amyloid misfolding disorders.
Microbially Induced Calcium Carbonate Precipitation as a Bioremediation Technique for Mining Waste

Mining waste represents a global issue due to its potential of generating acidic or alkaline leachate with high concentrations of metals and metalloids (metal(loid)s). Microbial-induced calcium carbonate precipitation (MICP) is an engineering tool used for remediation. MICP, induced via biological activity, aims to precipitate calcium carbonate (CaCO3) or co-precipitate other metal carbonates (MCO3). MICP is a bio-geochemical remediation method that aims to immobilize or remove metal(loid)s via enzyme, redox, or photosynthetic metabolic pathways. Contaminants are removed directly through immobilization as mineral precipitates (CaCO3 or MCO3), or indirectly (via sorption, complexes, or inclusion into the crystal structure). Further, CaCO3 precipitates deposited on the surface or within the pore spaces of a solid matrix create a clogging effect to reduce contaminant leachate. Experimental research on MICP has shown its promise as a bioremediation technique for mining waste. Additional research is required to evaluate the long-term feasibility and potential by-products of MICP-treated/stabilized waste.
Automatic Instantaneous Attitude Estimation Framework for Spacecraft Based on Colocated Optical/ISAR Observation

Instantaneous attitude estimation for spacecraft through optical/inverse synthetic aperture radar (ISAR) fusion observation is a hot topic in space situational awareness. However, due to the imaging characteristics and domain gap between the two data types, it is difficult to autonomously estimate instantaneous attitudes based on data fusion. In this letter, an automatic optical/ISAR multifeature fusion instantaneous attitude estimation framework is proposed. We deploy semantic feature extraction networks to extract and associate two kinds of robust features in optical and ISAR images, and an attitude estimation algorithm considering cross-range scaling based on multiple feature combinations is proposed. Meanwhile, the inherent structure constraints of spacecraft are introduced. Simulation experiments demonstrate that the proposed framework achieves an average attitude estimation accuracy of 1.87°, while also exhibiting excellent robustness.
Secondary production of the net-spinning cadisfly, Cheumatopsyche spp. (Trichoptera: Hydropsychidae) in mercuric contaminated river

Cikaniki River is located in Bogor regency, West Java, Indonesia. The river has been contaminated with mercury because of small-scale gold processing. In this paper, secondary production of Cheumatopsyche spp. in Cikaniki River was studied. The aim of this study was to determine the impact of mercury contamination in the river to the production and turnover of Cheumatopsyche spp. Three locations - Cisarua, Curug Bitung and Lukut, were chosen to represent gold amalgamation activities position in the river. Production of Cheumatopsyche spp. was determined using the size-frequency method. The dissolved mercury concentration at the three locations ranged from undetected at all locations to 4.01 цg dm-3 at Cisarua. Higher mercury concentrations were observed on particulate form, which from upstream to downstream were 73.26 цg dm-3, 114.44 цg dm-3, and 52.37 цg dm-3, respectively. Particulate Hg were related with the TSS concentration in the river. Particulate Hg were about 30 % to almost half (48 %) of the TSS. The highest annual production of Cheumatopsyche spp. in Cikaniki River occurred at Lukut with 7127.96 mg m-2 y-1, followed by Cisarua at 793.94 mg m-2 y-1, and the lowest was at Curug Bitung at 408.31 mg m-2 y-1. The highest annual P/B (turn over) of the caddisfly in Cikaniki River was observed at the downstream of the river, Lukut 11.95, followed by Cisarua 7.32, and the last was Curug Bitung 6.00. Cohort P/Bs of Cheumatopsyche spp. were about half of their annual P/B. We conclude that Cheumatopsyche secondary production in Cikaniki River was affected by particulate Hg and TSS concentration in the river water. Our result shows that gold amalgamation at the river bank should be regulated to prevent mercuric pollution in Cikaniki River.
Effects of Lake Erie hypoxia on fish habitat quality and yellow perch behavior and physiology

Almeida, Leah Zoe M.S., Purdue University, May 2016. Effects of Lake Erie Hypoxia on Fish Habitat Quality and Yellow Perch Behavior and Physiology. Major Professors: Tomas O. Höök. Hypoxia is a concern in freshwater, marine, and estuarine systems worldwide including in Lake Erie, North America. Hypoxia may develop more frequently and for a longer duration as a result of excess nutrient loading from human sources, therefore, the incidence of hypoxic areas has increased with human population increases and intensive land-use practices. The effects of hypoxia on fish and other aquatic organisms have been well-studied, but most research examines the negative aspects of hypoxia development on habitats and the effect of severe hypoxia on individuals. In this study we focused on less studied and more subtle effects of hypoxia, including the possible benefits of prey increases that can occur concomitantly with increased hypoxia and the behavioral and physiological responses of yellow perch (Perca flavescens) to moderate hypoxia. First, we examined the balance between the potential beneficial and detrimental aspects of nutrient loading and hypoxia on habitat quality for four fishes and two life-stages using a growth rate potential model (GRP). Although nutrient loading did increase prey biomass in model simulations, it also caused a decline in overall habitat quality due to the spatial and temporal expansion of hypoxia. Nutrient loading also increased habitat quality, but
SENTIMENT ANALYSIS OF PUBLIC OPINIONS TOWARDS TELKOM UNIVERSITY POST PANDEMIC

Abstract: Twitter, as a social media platform, has rapidly grown as a means for people to express their opinions and thoughts on various topics, including education. The number of Twitter users surged to 10.645. 000 in 2020, with a significant increase during the pandemic. Telkom University, as a private institution of higher education in Indonesia, has become one of the topics of discussion on Twitter. Users’ opinions about Telkom University vary, ranging from positive to negative. To gain deeper insights into public view, sentiment analysis is essential. The analysis follows the Knowledge Discovery in Databases (KDD) process, utilizing the Naive Bayes classification algorithm. The evaluation results indicate the best accuracy achieved with an 80:20 data split, resulting in an accuracy rate of 82.05%, precision of 82.3%, recall of 82.05%, and F1-Score of 82.08%. The Naïve Bayes model demonstrates good performance for sentiment analysis of public views regarding Telkom University on Twitter. Keywords: naïve bayes; sentiment analysis; twitter; telkom university. Abstrak: Media sosial Twitter berkembang pesat sebagai sarana masyarakat berekspresi untuk menuangkan opini dan pikiran mereka mengenai topik apapun, termasuk pendidikan. Pengguna Twitter meningkat tajam hingga 10.645. 00 pengguna pada tahun 2020 dan terus meningkat selama pandemi. Telkom University sebagai perguruan tinggi menjadi salah satu topik yang dibicarakan yang berkaitan dengan pendidikan. Pendapat mengenai Telkom University yang diungkapkan oleh pengguna Twitter beragam, baik positif maupun negatif. Analisis sentimen diperlukan untuk memahami pandangan publik lebih mendalam. Digunakan tahapan Knowledge Discovery in Databases dan algoritma klasifikasi Naïve Bayes dalam analisis ini. Hasil evaluasi menunjukkan akurasi paling baik dicapai dengan rasio data 80:20, dengan nilai akurasi sebesar 82.05%, nilai presisi sebesar 82.3%, nilai recall sebesar 82.05%, dan nilai F1-Score sebesar 82.08%. Model klasifikasi Naïve Bayes memiliki performa baik untuk analisis sentimen pandangan publik di Twitter mengenai Telkom University. Kata kunci: analisis sentimen; naïve bayes; twitter; telkom university.
Experimental Investigation of the Processes of Fossilization

Investigation of the early, preburial phases of the taphonomic (fossilization) process leads to an enhanced understanding of the fossil record. The simple laboratory experiment described herein demonstrates the relative rates of decay and disarticulation of hard-parts, nonmineralized skeletal parts, and internal soft-parts of animals, plants, and fungi. Experimental conditions involving marine and fresh water, oxic and anoxic water, and protected and unprotected subaerial (terrestrial) depositional settings mimic a broad spectrum of depositional environments. Results from the experiment, which are in good agreement with preservational patterns in the fossil record as a whole, help students understand what organisms and body parts are preserved under ordinary depositional conditions. They also help students interpret some of the major controls on the extraordinary preservation of organisms in such units as the Burgess Shale (Cambrian), the Chengjiang Lagerstatte (Cambrian), the Mazon Creek Lagerstatte (Pen.
Enhancement of Control Performance for Degraded Robot Manipulators Using Digital Twin and Proximal Policy Optimization

In this study, we propose a novel method for enhancing the control performance of a degraded robot manipulator by leveraging digital twins and proximal policy optimization, a specific deep reinforcement learning algorithm. Recently, various robotic technologies with high levels of controllability, safety, and reliability that incorporate the fourth industrial technology have been developed. Nevertheless, repairs or replacements owing to the performance degradation of sophisticated robot hardware or control systems are still time-, cost-, and manpower-consuming. To address these challenges, we propose a new strategy:1) approximate the unstable dynamic characteristics of six-degree-of-freedom low-performance robot manipulators to a digital twin with parameter tuning of a physics engine; 2) improve the accuracy and stability of reaching target points under diverse conditions through deep reinforcement learning using the domain randomization method; and 3) deploy a trained policy on an actual robot manipulator with degraded capabilities to validate the control performance improvement. Our method reduced the position error of a real robot manipulator by 63.0% and 39.0% compared to the built-in control method and the proportional-integral-derivative control method, respectively. Randomizing parameters in the physics engine of the digital twin during training allowed the method to simulate the imprecise motions of an actual degraded robot manipulator, facilitating the development of a more robust policy. Notably, our method has the potential to be applicable to all types of articulated robots, and presents a promising solution for maintaining performance while reducing long-term costs.
Generalization of Homotopy Analysis Method for q-Fractional Non-linear Differential Equations

This paper presents a generalization of the Homotopy analysis method (HAM) for finding the solutions of nonlinear q-fractional differential equations (q-FDEs). This method shows that the series solution in the case of generalized HAM is more likely to converge than that on HAM. In order that it is applicable to solve immensely non-linear problems and also address a few issues, such as the impact of varying the auxiliary parameter, auxiliary function, and auxiliary linear operator on the order of convergence of the method. The generalized HAM method is more accurate than the HAM.
Miniaturized Stepped Impedance Transmission Lines for D-Band Wideband Power Divider With Isolation Capacitor

In this letter, a broadband Wilkinson power divider (WPD) with small size and low loss using round-shaped stepped impedance transmission lines (RS-SITLs) is proposed in both differential and single-ended structures. Miniaturization was achieved through the SITLs with an electrical length smaller than 90°. The insufficient length for odd-mode matching is addressed by introducing an isolation capacitor. Physical parameters are determined considering feasible characteristic impedances through respective mode analyses. Chips are fabricated using a 40-nm RF CMOS process, resulting in a 25% reduction in area compared to the conventional WPD with a <inline-formula> <tex-math notation="LaTeX">$\boldsymbol{\lambda }$ </tex-math></inline-formula>/4 transmission line, with a core size as small as <inline-formula> <tex-math notation="LaTeX">$0.002~\lambda ^{2}$ </tex-math></inline-formula>. In the 110–170-GHz band, the proposed single-ended and differential SITL WPDs, respectively, have low-insertion losses (ILs) of 0.91 and 0.69 dB and high isolations (ISOs) of 14.7 and 15.3 dB.
Optimizing the Multimerization Properties of Quinoline-Based Allosteric HIV-1 Integrase Inhibitors

Allosteric HIV-1 Integrase (IN) Inhibitors or ALLINIs bind at the dimer interface of the IN, away from the enzymatic catalytic site, and disable viral replication by inducing over-multimerization of IN. Interestingly, these inhibitors are capable of impacting both the early and late stages of viral replication. To better understand the important binding features of multi-substituted quinoline-based ALLINIs, we have surveyed published studies on IN multimerization and antiviral properties of various substituted quinolines at the 4, 6, 7, and 8 positions. Here we show how the efficacy of these inhibitors can be modulated by the nature of the substitutions at those positions. These features not only improve the overall antiviral potencies of these compounds but also significantly shift the selectivity toward the viral maturation stage. Thus, to fully maximize the potency of ALLINIs, the interactions between the inhibitor and multiple IN subunits need to be simultaneously optimized.
Performance Measures and Plasma Biomarker Levels in Patients with Multiple Sclerosis after 14 Days of Fampridine Treatment: An Explorative Study

Peripheral cytokine levels may serve as biomarkers for treatment response and disease monitoring in patients with multiple sclerosis (pwMS). The objectives were to assess changes in plasma biomarkers in PwMS after 14 days of fampridine treatment and to explore correlations between changes in performance measures and plasma biomarkers. We included 27 PwMS, 14 women and 13 men, aged 52.0 ± 11.6 years, with a disease duration of 17 ± 8.5 years, and an Expanded Disability Status Scale of 6 [IQR 5.0/6.5]. Gait and hand function were assessed using performance tests completed prior to fampridine and after 14 days of treatment. Venous blood was obtained, and chemiluminescence analysis conducted to assess plasma cytokines and neurodegenerative markers. All performance measures demonstrated improvements. Biomarkers showed decreased tumor necrosis factor (TNF) receptor-2 levels. Associations were found between change scores in (i) Six Spot Step Test and Interleukin (IL)-2, IL-8, and IL-17 levels; (ii) timed 25-foot walk and interferon-γ, IL-2, IL-8, TNF-α, and neurofilament light levels, and (iii) 12-Item Multiple Sclerosis Walking Scale and IL-17 levels. The associations may reflect increased MS-related inflammatory activity rather than a fampridine-induced response or that a higher level of inflammation induces a better response to fampridine.
Principle, the State-of-art Facility and Application of MRI

With the continuous development of science and technology, human beings have higher and higher medical needs, but in the past, people did not have a deep understanding of MRI. This article intends to use the survey method to explore MRI, hoping to promote people's understanding of MRI. The main direction of this research article is the principle and application of MRI. This article is divided into 6 main parts. The first part introduces the development history of MRI and the research progress in recent years. The second part explains the components and the types of MRI. The third part analyzes the principle of MRI. The fourth part introduces the latest MRI with the instrument equipment and parameters. The fifth part analyzes the main application range of MRI, and the sixth part explains the current limitations of MRI. Through the research on MRI, we found that the current MRI has limitations, and the high cost also makes some patients daunted by MRI. These results offer a comprehensive discussion for MRI, shedding light on guiding further exploration of MRI.
Protection and Progress of the Marine Environment

The marine environment is an important part of the earth's ecosystem and is of great significance to maintaining the earth's ecological balance and the sustainable development of human beings. However, due to undue interference and pollution from human activities, the marine environment is facing serious threats. The aim is to explore the importance of protecting the marine environment and propose some feasible measures to reduce marine pollution and protect marine biodiversity. In a word, the research on marine environmental protection is of great significance for maintaining ecological balance, protecting endangered species, regulating climate, rationally utilizing resources and reducing environmental pollution. Through scientific research and reasonable management, we can protect and make good use of marine resources and create good conditions for future sustainable development. In recent years, various countries and the United Nations government have formulated many laws and policies on ocean protection, but these laws are still flawed and need to be improved and supplemented.
How Do Tourists’ Value Perceptions of Food Experiences Influence Their Perceived Destination Image and Revisit Intention? A Moderated Mediation Model

The food experience is an important part of the tourism experience. Although it is crucial to comprehend the significance of tourists’ perception of food experiences, there is a scarcity of research investigating the impact of tasting local food on tourists’ perceptions and behaviors. This study employs structural equation modeling to empirically examine the relationship between tourists’ value perceptions of food experiences, their perceived destination image, and their revisit intention. In addition, the moderating effects of tourists’ genders on the aforementioned relationships are also explored. A renowned restaurant brand, Nanjing Impressions, which specializes in offering the unique cuisine of the city of Nanjing, China, is chosen as the research case. A grand total of 500 questionnaires were distributed, and, out of these, 458 questionnaires were deemed legitimate and kept for further analysis. The results indicate that the functional, social, emotional, cultural, and health values of local food experienced by tourists have significant positive impacts on their perceived destination image and revisit intention. Moreover, perceived destination image partially mediates the relationships between tourists’ value perceptions of food experiences and their revisit intention. Gender is found to partially moderate the relationships between the proposed constructs. The current study offers noteworthy theoretical contributions and provides valuable practical suggestions for tourism destination managers.