Miracle-dz/UniFAR-FTUs huggingface dataset:
Changing Perceptions of University of Calgary Students over a One-Year Period

The role or position of university personnel workers has often been given a distorted or inaccurate description by students and adults. There may be various reasons for these inaccuracies, such as the newness of a position, role confusion as related to training, or qualification. Sonne and Goldman (1957) found that expectations and preferences of counselling clients were learned, and were related to social and cultural in­ fluence. Deutsch and Gerard (1955) and Thibault and Strickland (1956) studied the proces of social influence. They found that responses and deci­ sions were many times made in accordance with the satisfaction and positive expectations of an individual or a group. Confronted with these variables of influence, people often experience a great deal of difficulty and anxiety in selecting a source of help. It seems plausible to assume that if a source has been contacted and little satisfaction gained, inaccurate and unjust descriptions may be given that service. To make certain types of decisions, students often find it necessary to gain assistance from other people. Grant (1954) and King and Matteson (1959) investigated the type of assistance students expected from a counsel­ lor and found that educational and vocational types of problems gained priority. One purpose of this investigation was to determine what specific people university students consult when confronted with a problem. Another pur­ pose was to determine whether students' perceptions change after a one-year period. During the second week of the 1965-66 academic year, 150 freshmen students in the compulsory English course at The University of Calgary were asked to respond to an adaptation of the Counselling Appropriateness Check­ List (Warman, 1960). Instructors administered the questionnaire and student participation was on a voluntary basis. One year later the same questionnaire was mailed to the same sample of students and 124 questionnaires were found acceptable for evaluation. The Counselling Appropriateness Check-List contains 66 items. The three areas of the Check-List and sample items of each area are as follows: 1. College Routine. This factor seems to represent adjustment to the necessities and routine of establishing oneself satisfactorily in the academic setting. a) not knowing how to study effectively b) going in debt for school expenses c) getting back in school after dismissal
Optimizing neural model templates using covariance matrix adaptation and fourier analysis

Advancement in neural modeling requires the development of methods for deriving computational models from observed biological data. We propose general analysis techniques to construct distance measures that are applicable across a broad range of cell types. We investigate the use of multiple stimuli to evoke model behaviors characteristic of the underlying channel densities. We examine the use of frequency analysis on multiple membrane recordings to improve channel density optimization for two simple compartment models. Applying the Covariance Matrix Adaptation (CMA-ES) [1] to this problem yielded near optimal resuits. Solutions given by CMA-ES are equivalent to parameter distributions and serve as templates for neural model generation.
α3β1 integrin modulates neuronal migration and placement during early stages of cerebral cortical development

We show that α3 integrin mutation disrupts distinct aspects of neuronal migration and placement in the cerebral cortex. The preplate develops normally in α3 integrin mutant mice. However, time lapse imaging of migrating neurons in embryonic cortical slices indicates retarded radial and tangential migration of neurons, but not ventricular zone-directed migration. Examination of the actin cytoskeleton of α3 integrin mutant cortical cells reveals aberrant actin cytoskeletal dynamics at the leading edges. Deficits are also evident in the ability of developing neurons to probe their cellular environment with filopodial and lamellipodial activity. Calbindin or calretinin positive upper layer neurons as well as the deep layer neurons ofα 3 integrin mutant mice expressing EGFP were misplaced. These results suggest that α3β1 integrin deficiency impairs distinct patterns of neuronal migration and placement through dysregulated actin dynamics and defective ability to search and respond to migration modulating cues in the developing cortex.
Mitophagy: a complex mechanism of mitochondrial removal.

SIGNIFICANCE Mitochondrial dynamics and turnover are crucial for cellular homeostasis and differentiation. The removal of damaged mitochondria that could contribute to cellular dysfunction or death is achieved through the process of mitochondrial autophagy, i.e., mitophagy. Moreover, mitophagy is responsible for removal of mitochondria during terminal differentiation of red blood cells and T cells. RECENT ADVANCES Recent work is elucidating how mitochondria are recognized for selective mitophagy either by PINK1 and Parkin or mitophagic receptors Nix and Bnip3 and their accompanying modulators. PINK1/Parkin-mediated mitophagy reveals their role of cargo recognition through polyubiquitination of mitochondrial proteins, while Nix functions as a regulated mitophagy receptor. These recognized modes of capture by the autophagy machinery operate at different efficiencies, from partial to complete elimination of mitochondria. CRITICAL ISSUES It is critical to understand that the distinct regulatory mechanisms involve not only autophagy machinery, but also proteins associated with mitochondrial fusion and fission and therefore, regulation of mitochondrial morphology. The end result is either finely tuned quality control of damaged mitochondria, or mitochondrial clearance during development- induced mitophagy. FUTURE DIRECTIONS In this article, known mechanisms and future directions for deciphering the challenge of mitophagy regulation will be discussed.
International classification of diseases, 10th edition, clinical modification and procedure coding system: descriptive overview of the next generation HIPAA code sets

Described are the changes to ICD-10-CM and PCS and potential challenges regarding their use in the US for financial and administrative transaction coding under HIPAA in 2013. Using author constructed derivative databases for ICD-10-CM and PCS it was found that ICD-10-CM's overall term content is seven times larger than ICD-9-CM: only 3.2 times larger in those chapters describing disease or symptoms, but 14.1 times larger in injury and cause sections. A new multi-axial approach ICD-10-PCS increased size 18-fold from its prior version. New ICD-10-CM and PCS reflect a corresponding improvement in specificity and content. The forthcoming required national switch to these new administrative codes, coupled with nearly simultaneous widespread introduction of clinical systems and terminologies, requires substantial changes in US administrative systems. Through coordination of terminologies, the systems using them, and healthcare objectives, we can maximize the improvement achieved and engender beneficial data reuse for multiple purposes, with minimal transformations.
The UnCivic Culture: Communication, Identity, and the Rise of Lifestyle Politics

by W. Lance Bennett University of Washington I t is a great honor to deliver the Ithiel de Sola Pool Lecture. Ithiel Pool was one of the grand visionaries of the modern social sciences. As a founder of the field we call political communication, he traced the great outlines of communication and politics from printing to electronic media. The evolution of these technologies of freedom, as he called them (Pool 1983), introduced a "soft determinism" into the course of human history by enabling vast numbers of decentralized transactions to cross the globe with fewer limits imposed by time, space, politics, or culture. In thinking about the advancement of human freedom, Pool was pessimistic about governments and optimistic about individuals. He understood that governments routinely make monumental policy errors with new technologies—errors often based on little more than the unwitting categorization of new media. Among the policy blunders that most distressed Pool was the (continuing) distinction between print and electronic media based on dubious economic and technological notions of channel scarcity rather than more fundamental political notions of individual access and content diversity. Such category mistakes have resulted in cumbersome governmental intrusions that, variously, inhibit the development of integrated communication systems, create monopolies in the name of protecting the weak, and, ultimately, restrict freedom of individual choice, access, and privacy (Pool 1983, 226-51).
Proteins of Excitable Membranes

Excitable membranes have the special ability of changing rapidly and reversibly their permeability to ions, thereby controlling the ion movements that carry the electric currents propagating nerve impulses. Acetylcholine (ACh) is the specific signal which is released by excitation and is recognized by a specific protein, the ACh-receptor; it induces a conformational change, triggering off a sequence of reactions resulting in increased permeability. The hydrolysis of ACh by ACh-esterase restores the barrier to ions. The enzymes hydrolyzing and forming ACh and the receptor protein are present in the various types of excitable membranes. Properties of the two proteins directly associated with electrical activity, receptor and esterase, will be described in this and subsequent lectures. ACh-esterase has been shown to be located within the excitable membranes. Potent enzyme inhibitors block electrical activity demonstrating the essential role in this function. The enzyme has been recently crystallized and some protein properties will be described. The monocellular electroplax preparation offers a uniquely favorable material for analyzing the properties of the ACh-receptor and its relation to function. The essential role of the receptor in electrical activity has been demonstrated with specific receptor inhibitors. Recent data show the basically similar role of ACh in the axonal and junctional membranes; the differences of electrical events and pharmacological actions are due to variations of shape, structural organization, and environment.
A Survey on Bimanual Haptic Interaction

When interacting with virtual objects through haptic devices, most of the time only one hand is involved. However, the increase of computational power, along with the decrease of device costs, allow more and more the use of dual haptic devices. The field which encompasses all studies of the haptic interaction with either remote or virtual environments using both hands of the same person is referred to as bimanual haptics. It differs from the common unimanual haptic field notably due to specificities of the human bimanual haptic system, e.g., the dominance of the hands, their differences in perception and their interactions at a cognitive level. These specificities call for adapted solutions in terms of hardware and software when applying the use of two hands to computer haptics. This paper reviews the state of the art on bimanual haptics, encompassing the human factors in bimanual haptic interaction, the currently available bimanual haptic devices, the software solutions for two-handed haptic interaction, and the existing interaction techniques.
Gazing into the Abyss: Real-time Gaze Estimation

Gaze and face tracking algorithms have traditionally battled a compromise between computational complexity and accuracy; the most accurate neural net algorithms cannot be implemented in real time, but less complex real-time algorithms suffer from higher error. This project seeks to better bridge that gap by improving on real-time eye and facial recognition algorithms in order to develop accurate, real-time gaze estimation with an emphasis on minimizing training data and computational complexity. Our goal is to use eye and facial recognition techniques to enable users to perform limited tasks based on gaze and facial input using only a standard, low-quality web cam found in most modern laptops and smart phones and the limited computational power and training data typical of those scenarios. We therefore identified seven promising, fundamentally different algorithms based on different user features and developed one outstanding, one workable, and one honorable mention gaze tracking pipelines that match the performance of modern gaze trackers while using no training data.
Strengths and Limitations of the Personality Inventory for Youth (PIY) in Juvenile Delinquency Assessments

This article highlights and discusses the usefulness of the Personality Inventory for Youth (PIY) in juvenile delinquency assessments. Psychiatric disorders have high prevalence rates among youths in the juvenile justice system. The PIY was developed to evaluate a broad range of behavioral and psychological characteristics, which may make it useful in juvenile delinquency assessment contexts. Practical and psychometric strengths and limitations of the PIY in the juvenile delinquency assessment context are presented, with reference to relevant research literature. The effectiveness of this instrument in detecting response bias, particularly under-reporting, and for identifying problems associated with delinquency is discussed. The issue of item overlap and spurious influences on scale correlations, especially between the PIY Defensiveness and Delinquency scales, is also addressed. A comparison of findings with the PIY and the Minnesota Multiphasic Personality Inventory–Adolescent (MMPI-A) in juvenile justice samples helps to identify broader considerations about how youths in juvenile justice settings respond to self-report psychological inventories. Finally, the author offers some practical considerations for evaluators when using the PIY in juvenile delinquency assessments, and suggestions for future research.
Lessons for the Future from the Margins of Psychology

Having spent 40 years as a psychologist in academia with a minority perspective at odds with the culture of his profession, the author was requested to reflect upon his experiences in order to offer advice to younger colleagues of the same persuasion. There are indeed prices to be paid when one's values place one outside the established view within the discipline of psychology, but remaining true to oneself is never theless posited as the highest value. The chief drawback of marginality is the lack of the possibility of being placed within a normative university setting where the training of the next generation of scholars with similar values can take place. Basically, one encounters the resistances that sociology of knowledge factors offer rather than intrinsic resistances to the minority theoretical perspective. Five theoretical notions that met political resistance are listed and seven advisory comments are offered for young potentially marginal psychologists.
Organization, Trust and Control: A Realist Analysis

This paper develops a critical realist analysis of trust/control relations within and between complex organizations. It suggests that trust/control relations are most usefully seen as structures of interrelated `positioned-practices' which generate, shape and constrain the development of contrasting forms of expert power in a range of organizational contexts. The paper opens with a general overview of a number of currently influential theoretical perspectives on trust/control relations in social and organizational analysis. It then proceeds to advance a critical realist analysis of trust/control relations as generative mechanisms that govern, but do not determine, the production, reproduction and transformation of expert power. The explanatory significance of this realist analysis is illustrated by reference to a limited number of historical and institutional case studies on expert technologies and practices
Differential and Common DNA Repair Pathways for Topoisomerase I- and II-Targeted Drugs in a Genetic DT40 Repair Cell Screen Panel

Clinical topoisomerase I (Top1) and II (Top2) inhibitors trap topoisomerases on DNA, thereby inducing protein-linked DNA breaks. Cancer cells resist the drugs by removing topoisomerase-DNA complexes, and repairing the drug-induced DNA double-strand breaks (DSB) by homologous recombination and nonhomologous end joining (NHEJ). Because numerous enzymes and cofactors are involved in the removal of the topoisomerase-DNA complexes and DSB repair, it has been challenging to comprehensively analyze the relative contribution of multiple genetic pathways in vertebrate cells. Comprehending the relative contribution of individual repair factors would give insights into the lesions induced by the inhibitors and genetic determinants of response. Ultimately, this information would be useful to target specific pathways to augment the therapeutic activity of topoisomerase inhibitors. To this end, we put together 48 isogenic DT40 mutant cells deficient in DNA repair and generated one cell line deficient in autophagy (ATG5). Sensitivity profiles were established for three clinically relevant Top1 inhibitors (camptothecin and the indenoisoquinolines LMP400 and LMP776) and three Top2 inhibitors (etoposide, doxorubicin, and ICRF-193). Highly significant correlations were found among Top1 inhibitors as well as Top2 inhibitors, whereas the profiles of Top1 inhibitors were different from those of Top2 inhibitors. Most distinct repair pathways between Top1 and Top2 inhibitors include NHEJ, TDP1, TDP2, PARP1, and Fanconi Anemia genes, whereas homologous recombination seems relevant especially for Top1 and, to a lesser extent, for Top2 inhibitors. We also found and discuss differential pathways among Top1 inhibitors and Top2 inhibitors. Mol Cancer Ther; 13(1); 214–20. ©2013 AACR.
Dioxin Induces an Estrogen-Like, Estrogen Receptor-Dependent Gene Expression Response in the Murine Uterus

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a ubiquitous environmental contaminant that elicits a broad range of toxicities in a tissue-, sex-, age-, and species-specific manner, including alterations in estrogen signaling. Many, if not all, of these effects involve changes in gene expression mediated via the activation of the aryl hydrocarbon receptor (AhR), a ligand activated transcription factor. Recent data indicate that TCDD may also elicit AhR-mediated estrogenic activity through interactions with the estrogen receptor (ER). In an effort to further characterize the estrogenic activity of TCDD, a comprehensive time-course analysis of uterine gene expression was conducted using ovariectomized C57BL/6 mice. Comparison of the temporal uterine transcriptional response to TCDD with that of ethynyl estradiol (EE) revealed a large proportion of the TCDD-mediated gene expression changes were also responsive to EE. Furthermore, pretreatment of mice with the pure ER antagonist ICI 182 780 (faslodex) inhibited gene expression responses to both EE and TCDD, providing additional evidence that these transcriptional responses involve the ER.
Perceptions of the Impact of Childhood Relationships Among Chemically Dependent Women

Abstract The perceptions of childhood and adolescent relationships among chemically dependent women who are new in recovery are examined. Participants placed themselves in social and psychological contexts as they described the impact of significant inter-personal relationships on their lives. Two relevant and descriptive categories of responses were developed based on participants' narratives: “childhood marked by inconsistent family support” and “adolescence notable for adult disregard. ” Implications for substance abuse counseling include emphasis on emotional support and encouragement for clients in enriching therapeutic environments.
A Family of DC-DC Multiplier Converters

with the Cockcroft–Walton voltage multiplier, the voltage multiplier of each converter is driven with the same transistor of the basic topology; this fact makes the structure of the new converters very simple and provides high-voltage gain. The traditional topologies discussed are the boost, buck-boost, Cuk and SEPIC. They main features of the discussed family are: (i) high-voltage gain without using extreme duty cycles or transformers, which allow high switching frequency and (ii) low voltage stress in switching devices, along with modular structures, and more output levels can be added without modifying the main circuit, which is highly desirable in some applications such as renewable energy generation systems. It is shown how a multiplier converter can become a generalized topology and how some of the traditional converters and several state-of-the-art converters can be derived from the generalized topologies and vice-versa. All the discussed converters were simulated, additionally experimental results are provided with an interleaved multiplier converter.
Learning social relations for culture aware interaction

Each person has their private physical and/or psychological area where they do not want to share with others during social interactions. This area gives them comfort about interactions and its size usually depends on various factors such as culture, personal traits, and acquaintanceship. This issue may also arise in case of human-robot interaction, especially when the robot is required to generate a socially competent interaction strategy toward people they are interacting with. Here, we propose a new robot exploration strategy to socially interact with people by considering the social relationship between the robot and each person. To that end, two definitions of interaction area are made: (1) Acceptable area allowed to be shared with other people and robots, and (2) Private area where a human does not want to be interfered by others. Based on these definitions, the robot can optimize the path to maximize the frequency/degree of visiting the acceptable area of each person and to minimize the frequency/degree of trespassing into the private area of them at the same time in an iterative way. In this paper, the social force model (SFM) of each person, based on the potential field concept, is designed by a fuzzy inference system and its parameter is optimized by the reinforcement learning model during interactions. We have shown that the proposed model can generate a suitable SFM of each person, which was quite similar to a ground truth model, allowing to plan a path to simultaneously optimize the two factors of interaction area, respectively.