Miracle-dz/UniFAR-FTUs huggingface dataset:
Process-Integrated Lubrication in Sheet Metal Forming

The deep-drawability of a sheet metal blank is strongly influenced by the tribological conditions prevailing in a deep-drawing process. Therefore, new methods to influence the tribology represent an important research topic. In this work, the application of a process-integrated lubrication in a deep-drawing process is investigated. Most promising geometries of the lubrication channels and outlet openings are first identified by means of numerical simulation at the example of a demonstrator process. Cylindrical test specimens with the specified channel geometries are additively manufactured and installed in a strip drawing test stand. Additive manufacturing enables the possibility of manufacturing complex channel geometries which cannot be manufactured by conventional methods. A hydraulic metering device for conveying lubricant is connected to the cylindrical test specimens. Thus, hydraulically lubricated strip drawing tests are performed. The tests are evaluated according to the force curves and the fluid mechanical buildup of pressure cushion. The performance of process-integrated lubrication is thus analyzed and evaluated. By means of a coupled forming and SPH simulation, the lubrication channels could be optimally designed. From the practical tests, it could be achieved that the drawing force decreases up to 27% with pressure cushion build up. In this research, a hydraulic lubrication in the area of highest contact normal stresses is the most optimal process parameter regarding friction reduction.
Soil quality in urban forests under different understory management practices

Forest vegetation management plays an important role in maintaining soil quality and function. In highly managed urban forests, the clearing of understory vegetation has potential to cause loss of soil nutrients, resulting in stoichiometric imbalances and a decrease in soil function. Whether the presence of ornamental understory in urban forests can mitigate the negative influences on soil quality remains highly uncertain. Here, we collected soil samples from a plantation forest in Zijin Shan National Forest Park in two stands, each with three adjacent plots with different understory management practices: one with natural understory vegetation (≥10 species), a second with managed understories of ornamental groundcover [Reineckea carnea (Andrews) Kunth or Ophiopogon bodinieri H. Lév], and a third with cleared understory. Compared with plots with natural understories, we found lower levels of soil total carbon (C), total nitrogen (N), and microbial C and N, in plots with no understories. Correspondingly, ratios of soil C:phosphorus (P) and N:P, and microbial C:N, were lower in the absence of understories in one of the two stands. The magnitude of these effects differed between the two stands, with greater effects observed in the stand with higher soil quality. These influences were smaller with groundcover plants in both stands, particularly O. bodinieri H. Lév. While we cannot rule out the effects of other influences on soil properties, these results offer support for the hypothesis that clearing of understories is potentially detrimental to soil quality, and that maintaining ornamental groundcover can alleviate these adverse influences in urban forest.
The Effect of Solar Direct Derive Cold Chain Equipment on the Performance of Immunization Services in Health Facilities of Ethiopia

The effect of solar direct derive (SDD) from cold chain equipment on the quality and equity of health facilities’ immunization services is assessed using descriptive and explanatory research design by collecting data using a structured questionnaire from health workers in health centres and health posts of 56 purposely selected health facilities in Ethiopia. Quantitative data were collected from the EPI registry for the year 2014 as a baseline, and a follow-up review was made for the year 2018 performances. It was found that the new cold chain equipment, SDD refrigerators have a positive and significant effect on improving equity (Penta 3 coverage) and quality (Penta 1 -Measles dropout rate) of the immunization service. This helps to reduce the number of zero dose children.
Patient Perspectives on Performance of a Smartphone App for Atrial FibrillationSelf-Management

Introduction AF self-care requires patients to perform daily self-monitoring for symptoms, practice decision making to address symptom changes, and adhere to prescribed medication, diet, physical activity, and follow-up care. Technology can facilitate these critical self-care behaviors and ultimately improve patient outcomes. We assessed atrial fibrillation (AF) patients’ experiences with a smartphone application (app) for AF self-management. Methods A focus group with 9 AF patients and app users was conducted and analyzed using qualitative research methods. The focus group was recorded, transcribed, and coded using a priori and inductive coding strategies. Participant responses for each code were synthesized to identify primary themes. Results We identified four superordinate themes from patients’ experiences: (1) disconnect between tool and its intended use; (2) app as acknowledged tool for adherence; (3) knowledge as empowerment; (3) motives: self-interest vs supporting research. Results from this qualitative study underscore the need to clarify the app’s intended use and to better accommodate patients with different AF experiences. The disconnect between a tool and its intended use can generate frustration for users. Discussion The study reinforces that participants not only see how the app is a tool for adherence; they also see knowledge they gain via the app as empowering, suggesting a correlation between app use and self-efficacy.
A Care Needs Assessment of Elderlies in Empty Nest Families: The Case of Wenzhou, China

China’s rapid modernization has resulted to significant shifts in its social, cultural, and economic makeup. Specifically, its population is ageing that threatens their economic growth trajectories. Because the tradition of “raise children against ageing” still has influence in Chinese society, the country is facing the issue of covering elderly care costs while ensuring continued support for everyone. Given China’s economic growth, we explore on how the needs of the elderly in empty nest families be fulfilled, particularly in Wenzhou where elderly population in empty nest families has been increasing. While both government and families demonstrate the need to care for the elderly by providing both tangible and intangible needs, survey results revealed that most elderlies in empty nest families in Wenzhou are satisfied living at home in their old age as long as they can still attend to themselves and can still find ways to satisfy their needs despite their age. These needs include continuing education, health consultations and assistance, and outpatient treatment. Knowing the specific needs of the elderlies in empty nest families allows government and families to direct resources on their actual needs that matter most rather than on perceived needs.
Blind Remote Sensing Image Deblurring Based on Overlapped Patches’ Non-Linear Prior

The remote sensing imaging environment is complex, in which many factors cause image blur. Thus, without prior knowledge, the restoration model established to obtain clear images can only rely on the observed blurry images. We still build the prior with extreme pixels but no longer traverse all pixels, such as the extreme channels. The features are extracted in units of patches, which are segmented from an image and partially overlap with each other. In this paper, we design a new prior, i.e., overlapped patches’ non-linear (OPNL) prior, derived from the ratio of extreme pixels affected by blurring in patches. The analysis of more than 5000 remote sensing images confirms that OPNL prior prefers clear images rather than blurry images in the restoration process. The complexity of the optimization problem is increased due to the introduction of OPNL prior, which makes it impossible to solve it directly. A related solving algorithm is established based on the projected alternating minimization (PAM) algorithm combined with the half-quadratic splitting method, the fast iterative shrinkage-thresholding algorithm (FISTA), fast Fourier transform (FFT), etc. Numerous experiments prove that this algorithm has excellent stability and effectiveness and has obtained competitive processing results in restoring remote sensing images.
An Efficient Agrobacterium rhizogenes-Mediated Hairy Root Transformation Method in a Soybean Root Biology Study

The stable genetic transformation of soybean is time-consuming and inefficient. As a simple and practical alternative method, hairy root transformation mediated by Agrobacterium rhizogenes is widely applied in studying root-specific processes, nodulation, biochemical and molecular functions of genes of interest, gene editing efficiency of CRISPR/Cas9, and biological reactors and producers. Therefore, many laboratories have developed unique protocols to obtain hairy roots in composite plants composed of transgenic roots and wild-type shoots. However, these protocols still suffer from the shortcomings of low efficiency and time, space, and cost consumption. To address this issue, we developed a new protocol efficient regeneration and transformation of hairy roots (eR&T) in soybean, by integrating and optimizing the main current methods to achieve high efficiency in both hairy root regeneration and transformation within a shorter period and using less space. By this eR&T method, we obtained 100% regeneration of hairy roots for all explants, with an average 63.7% of transformation frequency, which promoted the simultaneous and comparative analysis of the function of several genes. The eR&T was experimentally verified Promoter:GUS reporters, protein subcellular localization, and CRISPR/Cas9 gene editing experiments. Employing this approach, we identified several novel potential regulators of nodulation, and nucleoporins of the Nup107-160 sub-complex, which showed development-dependent and tissue-dependent expression patterns, indicating their important roles in nodulation in soybean. Thus, the new eR&T method is an efficient and economical approach for investigating not only root and nodule biology, but also gene function.
Application of the Mutant Libraries for Candida albicans Functional Genomics

Candida albicans is a typical opportunistic pathogen in humans that causes serious health risks in clinical fungal infections. The construction of mutant libraries has made remarkable developments in the study of C. albicans molecular and cellular biology with the ongoing advancements of gene editing, which include the application of CRISPR-Cas9 and novel high-efficient transposon. Large-scale genetic screens and genome-wide functional analysis accelerated the investigation of new genetic regulatory mechanisms associated with the pathogenicity and resistance to environmental stress in C. albicans. More importantly, sensitivity screening based on C. albicans mutant libraries is critical for the target identification of novel antifungal compounds, which leads to the discovery of Sec7p, Tfp1p, Gwt1p, Gln4p, and Erg11p. This review summarizes the main types of C. albicans mutant libraries and interprets their applications in morphogenesis, biofilm formation, fungus–host interactions, antifungal drug resistance, and target identification.
Investigation of round Scots pine wood WC01 class using X-ray computer tomography

Investigation of round Scots pine wood WC01 class using X-ray computer tomography. Scots pine is the most widespread type of wood in Poland with wide industrial use. The typical starting material used for the production of layered floor elements are logs of WC01 class (class according to the Polish Standard PN-D-95008: 1992 and Order no 72 - GM-900-5 / 2013 of General Director of the State Forests in Poland). Using X-ray computed tomography, tests of fresh wood in the bark were carried out, confirming the full suitability of this technique for the precise assessment of wood density as well as its grain and distribution of anatomical defects (knots). The different level of humidity of sapwood and heartwood in fresh wood is visible in tomographic images and translates into a much higher recorded density of the wetter zone of sapwood. Calibration of the tomograph used made it possible to convert the Hounsfield density scale into actual densities expressed in kg/m3.
Action learning and healthcare 2011–2022

ABSTRACT This paper provides a review of the use of action learning in healthcare organisations, or by healthcare professionals, in the past decade, as evidenced in peer-reviewed journals. Action learning has a long history in healthcare and is perhaps particularly suited to an environment where wicked problems abound, where professional development is prized, and where many of the professions subscribe to reflective practice as a vehicle of development. A systematic search for literature in peer-reviewed English language journals was undertaken, followed by a process of pursuing references from the publications revealed by that search. Papers that provided accounts or evaluations of programmes and projects that included action learning were analysed. Common themes concerning purposes, processes, benefits and challenges were identified. Action learning was used for three purposes in the projects and programmes: to improve an aspect of healthcare services; to develop skills of the participants; to enhance collective capability. Whilst in some cases the intention was to achieve all three beneficial outcomes, it was apparent that in the majority of examples one or another of these purposes was prioritised as the principal aim of the programme or project.
Genomic Insights into the Radiation-Resistant Capability of Sphingomonas qomolangmaensis S5-59T and Sphingomonas glaciei S8-45T, Two Novel Bacteria from the North Slope of Mount Everest

Mount Everest provides natural advantages to finding radiation-resistant extremophiles that are functionally mechanistic and possess commercial significance. (1) Background: Two bacterial strains, designated S5-59T and S8-45T, were isolated from moraine samples collected from the north slope of Mount Everest at altitudes of 5700m and 5100m above sea level. (2) Methods: The present study investigated the polyphasic features and genomic characteristics of S5-59T and S8-45T. (3) Results: The major fatty acids and the predominant respiratory menaquinone of S5-59T and S8-45T were summed as feature 3 (comprising C16:1 ω6c and/or C16:1 ω7c) and ubiquinone-10 (Q-10). Phylogenetic analyses based on 16S rRNA sequences and average nucleotide identity values among these two strains and their reference type strains were below the species demarcation thresholds of 98.65% and 95%. Strains S5-59T and S8-45T harbored great radiation resistance. The genomic analyses showed that DNA damage repair genes, such as mutL, mutS, radA, radC, recF, recN, etc., were present in the S5-59T and S8-45T strains. Additionally, strain S5-59T possessed more genes related to DNA protection proteins. The pan-genome analysis and horizontal gene transfers revealed that strains of Sphingomonas had a consistently homologous genetic evolutionary radiation resistance. Moreover, enzymatic antioxidative proteins also served critical roles in converting ROS into harmless molecules that resulted in resistance to radiation. Further, pigments and carotenoids such as zeaxanthin and alkylresorcinols of the non-enzymatic antioxidative system were also predicted to protect them from radiation. (4) Conclusions: Type strains S5-59T (=JCM 35564T =GDMCC 1.3193T) and S8-45T (=JCM 34749T =GDMCC 1.2715T) represent two novel species of the genus Sphingomonas with the proposed name Sphingomonas qomolangmaensis sp. nov. and Sphingomonas glaciei sp. nov. The type strains, S5-59T and S8-45T, were assessed in a deeply genomic study of their radiation-resistant mechanisms and this thus resulted in a further understanding of their greater potential application for the development of anti-radiation protective drugs.
Integration of single-cell RNA sequencing and spatial transcriptomics to reveal the glioblastoma heterogeneity

Glioblastoma (GBM), a deadly brain tumor, is still one of a few lasting challenges of contemporary oncology. Current therapies fail to significantly improve patient survival due to GBM tremendous genetic, transcriptomic, immunological, and sex-dependent heterogeneity. Over the years, clinical differences between males and females were characterized. For instance, higher incidence of GBM in males or distinct responses to cancer chemotherapy and immunotherapy between males and females have been noted. Despite the introduction of single-cell RNA sequencing and spatial transcriptomics, these differences were not further investigated as studies were focused only on revealing the general picture of GBM heterogeneity. Hence, in this mini-review, we summarized the current state of knowledge on GBM heterogeneity revealed by single-cell RNA sequencing and spatial transcriptomics with regard to genetics, immunology, and sex-dependent differences. Additionally, we highlighted future research directions which would fill the gap of knowledge on the impact of patient’s sex on the disease outcome.
Expression of AKT1 Related with Clinicopathological Parameters in Clear Cell Renal Cell Carcinoma

Pathways such as VEGF, EGF and mTOR are known to be one of the major mechanisms of tumorigenesis including kidney cancer. To identify potential signaling pathway proteins, we performed differential/correlation analyses of mTOR-associated genes from three public datasets. AKT1 protein, one of the PI3K/AKT/mTOR pathways, turned out to be the potential by showing a consistent discrepancy between ccRCC-associated conditions as well as strong correlation with other mTOR-associated genes across the datasets. Then, we analyzed how AKT1 alteration affects clear cell renal cell carcinoma. The pathology of 58 kidney cancer patients was constructed to analyze the relationship between the expression level of AKT1 through immunohistochemical staining and their clinicopathological data. Gender, age and TNM stage did not show significant results. AKT1 is a known oncogene. However, in this study, high expression of AKT1 showed a slight correlation with lower WHO/ISUP grade, longer recurrence-free and progression-free survival rates.
Diffusion coefficient and radial gradient of galactic cosmic rays

We present the temporal changes of the diffusion coefficient K of galactic cosmic rays (GCRs) at the Earth orbit calculated based on the experimental data using two different methods. The first approach is based on the Parker convection-diffusion approximation of GCR modulation [1]: i.e. K~Vr=dI where dI is the variation of the GCR intensity measured by neutron monitors (NM),V is the solar wind velocity and r is the radial distance. The second approach is based on the interplanetary magnetic field (IMF) data. It was suggested that parallel mean free path can be expressed in terms of B as in [2]-[4]. Using data of the product of the parallel mean free path and radial gradient of GCR calculated based on the GCR anisotropy data (Ahluwalia et al., this conference ICRC 2013, poster ID: 487 [5]), we estimate the temporal changes of the radial gradient of GCR at the Earth orbit. We show that the radial gradient exhibits a strong solar cycle dependence (11-year variation) and a weak solar magnetic cycle dependence (22-year variation), being in agreement with the previous other calculations and with PIONEER/VOYAGER observations.
Associations between Perception of Help-Seeking Behaviors and Quality of Life among Older People in Rural Communities: A Cross-Sectional Study

Older people’s help-seeking behaviors (HSBs) may be limited because of various factors and are essential in improving healthcare in aging societies. This cross-sectional study investigated the association between perception of HSBs, concrete HSBs, quality of life (QOL), and other variables among people over 65 in rural Japan using standardized questionnaires. Participants were divided into high or low health status index score groups based on a median split. Logistic regression was used to assess the association between perception of HSBs and high QOL while controlling for age, sex, living conditions, annual health checks, having chronic diseases, regular clinic visits, smoking, habitual alcohol consumption, education, living conditions, social support, social capital, socioeconomic status (SES), and health literacy. Participants in the high QOL group were younger (p < 0.001), and had fewer chronic diseases and regular clinic visits than those in the low QOL group (p < 0.001). The multivariate logistic regression model revealed that age, chronic diseases, tobacco usage, family consultation, and consulting primary care physicians negatively predicted QOL. High SES, social capital and support, and HSB intention positively predicted QOL. Self-efficacy and intention regarding HSBs should be investigated to improve health among older rural people.
Moisture Transport and Contribution to the Continental Precipitation

Understanding the water cycle change under a warming climate is essential, particularly the ocean to land moisture transport, which affects the precipitation over land areas and influences society and the ecosystem. Using ERA5 data from 1988 to 2020, the time series of moisture transport and the trend across the boundary of each continent, including Eurasia, Africa, North America, South America, Antarctic, Australia, and Greenland, have been investigated. The inflow and outflow sections of the moisture have been identified for each continent. The trends of moisture convergence over Eurasia, Africa, North America, and Antarctic are all positive, with the values of 2.59 ± 3.12, 2.60 ± 3.17, 12.98 ± 2.28, and 0.32 ± 0.47 (in 106 kg/s/decade), respectively, but only the trend over North America is statistically significant at a 0.1 significance level. The moisture convergence trend of −0.59 ± 3.63 (in 106 kg/s/decade) over South America is negative but insignificant. The positive trend of 0.10 ± 0.35 (in 106 kg/s/decade) over Greenland is very weak. The precipitation, evaporation, and moisture convergence are well balanced at middle and low latitudes, but the combination of moisture convergence and evaporation is systematically lower than the precipitation over Antarctic and Greenland. Contributions of evaporation and moisture convergence (or transport) to the continental precipitation vary with the continent, but the moisture convergence dominates the precipitation variability over all continents, and the significant correlation coefficients between the anomaly time series of continental mean moisture convergence and precipitation are higher than 0.8 in all continents.
Effects of little Higgs models on single top production at the $e^{-}\gamma$ colliders

In the framework of the littlest Higgs($LH$) model and the littlest Higgs model with T-parity($LHT$), We investigate the single top production process $e^{-}\gamma\to \nu_{e}b\bar{t}$, and calculate the corrections of these two models to the cross section of this process. We find that in the reasonable parameter space, the correction terms for the tree-level $Wtb$ couplings coming from the $LHT$ model can generate significantly corrections to the cross section of this process, which might be detected in the future high energy linear $e^{+}e^{-}$ collider($ILC$) experiments. However, the contributions of the new gauge boson $W^{\pm}_{H}$ predicted by the $LH$ model to this process is very small.