Miracle-dz/UniFAR-FTUs huggingface dataset:
Mental health of the population affected after natural disaster of 20 february 2010 in Madeira Autonomous Region

Natural disasters resulting from climate change have increased currently.More and more people feel unprotected without security and therefore vulnerable to stress and anxiety may cause lasting mental illness. Post-Traumatic Stress Disorder(PTSD), is an anxiety problem that develops in some people after extremely traumatic events, such as combat, crime, an accident or natural disaster.People with PTSD may relive the event via intrusive memories, flashbacks and nightmares; avoid anything that reminds them of the trauma; and have anxious feelings they didn’t have before that are so intense their lives are disrupt (APA, 2013). Identifying the natural disaster of the 20th February 2010 in the Autonomous Region of Madeira as a potentially traumatic event, the objectives of this research were: (1) to describe the levels of PTSD and dissociative responses to exposure to peritraumatic experiences associated with alluvial the natural disaster of February 20, 2010, in a sample of adults living in the Autonomous Region of wood (RAM), namly in the districts of Funchal, Santa Cruz and Ribeira Brava; (2) to analyze the relationship between the district of residence and levels of PTSD and dissociative responses to exposure to peritraumatic experiences; and (3) to assess the rate of occurrence of PTSD in these individuals. This cross-sectional study included a sample of 602 adults living in the districts most affected like Funchal, Ribeira Brava and Santa Cruz. The instruments for assessing the individuals were the Peritraumatic Experiences Questionnaire (QEPT; Maia, Moreira &Fernandes, 2009) and the Response Evaluation to Traumatic Event Scale (EARAT; McIntyre & Ventura, 1996). The majority of the population was exposed to significant peritraumatic experiences (85.4%) and about a quarter of the sample (25.4%) had criteria for the diagnosis of PTSD. Between the subsamples defined by district in respect to the average scores of the QEPT and subscale EARAT – Long term Responses we verify the existence of statistically significant differences. Most individuals exposed to significant peritraumaticexperiences was found in the sub-sample of Santa Cruz (90.5%) and the highest percentage of people diagnosed with PTSD was found in the sub-sample of Ribeira Brava (32.6%) The scientific importance and the clinical relevance of these findings, envision their usefulness in understanding the impact of this natural disaster with a view to the promotion of mental health in the support to victims of disasters in Madeira.
Failed Weaning from Mechanical Ventilation and Cardiac Dysfunction

Failure to transition patient from controlled mechanical ventilation to spontaneous breathing trials (SBTs) in a timely fashion is associated with significant morbidity and mortality in the intensive care unit. In addition, weaning failures are common in patients with limited cardiac reserves. Recent advances in cardiac echocardiography and laboratory measurement of serum biomarkers to assess hemodynamic response to SBT may provide additional information to guide clinicians to predict weaning outcome.
DOCUMENTACIÓN 3D DE LA COVA DELS CAVALLS Y DE SU ENTORNO (TÍRIG, CASTELLÓN)

Los resultados presentados se enmarcan dentro del proyecto de investigacion HAR2014–59873–R del Ministerio de Economia y Competitividad. Los autores agradecen a Diego Mosquera de FARO Spain su contribucion al facilitar el escaner.
The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER–plasma membrane junctions

The activation of store-operated Ca2+ entry by Ca2+ store depletion has long been hypothesized to occur via local interactions of the endoplasmic reticulum (ER) and plasma membrane, but the structure involved has never been identified. Store depletion causes the ER Ca2+ sensor stromal interacting molecule 1 (STIM1) to form puncta by accumulating in junctional ER located 10–25 nm from the plasma membrane (see Wu et al. on p. 803 of this issue). We have combined total internal reflection fluorescence (TIRF) microscopy and patch-clamp recording to localize STIM1 and sites of Ca2+ influx through open Ca2+ release–activated Ca2+ (CRAC) channels in Jurkat T cells after store depletion. CRAC channels open only in the immediate vicinity of STIM1 puncta, restricting Ca2+ entry to discrete sites comprising a small fraction of the cell surface. Orai1, an essential component of the CRAC channel, colocalizes with STIM1 after store depletion, providing a physical basis for the local activation of Ca2+ influx. These studies reveal for the first time that STIM1 and Orai1 move in a coordinated fashion to form closely apposed clusters in the ER and plasma membranes, thereby creating the elementary unit of store-operated Ca2+ entry.
The ontogeny of the Mississippian blastoid Orophocrinus

Plates grew by addition of calcite at their edges, but at different rates along different edges. Growth along one edge was constant, and is used as a datum for comparison of growth along other edges. Growth curves thus derived provide means of comparing ontogenies of different individuals, populations, or taxa. The genus is revised, the type species Orophocrinus stelliformis (Owen and Shumard) redescribed, and O. campanulatus (Hambach) and O. (Codaster) whitei Whitfield (non Hall, part) placed in its synonymy. Codaster whitei Hall is assigned to Hydroblastus. Orophocrinus occurs in Upper Kinderhookian and Lower Osagean series of Illinois, Iowa, Missouri, New Mexico, and Arizona, and in the Tournaisian and Visean of Europe.
A note on support recovery of sparse signals using linear programming

A new theory known as compressed sensing considers the problem to acquire and recover a sparse signal from its linear measurements. In this paper, we propose a new support recovery algorithm from noisy measurements based on the linear programming (LP). LP is widely used to estimate sparse signals, however, we focus on the problem to recover the support of sparse signals rather than the problem to estimate sparse signals themselves. First, we derive an integer linear programming (ILP) formulation for the support recovery problem. Then we obtain the LP based support recovery algorithm by relaxing the ILP. The proposed LP based recovery algorithm has an attracting property that the output of the algorithm is guaranteed to be the maximum a posteiori (MAP) estimate when it is integer valued. We compare the performance of the proposed algorithm to a state-of-the-art algorithm named sparse matching pursuit (SMP) via numerical simulations.
A geographic variant of the Staphylococcus aureus Panton-Valentine leukocidin toxin and the origin of community-associated methicillin-resistant S. aureus USA300.

BACKGROUND The majority of recent community-associated methicillin-resistant Staphylococcus aureus (MRSA) infections in the United States have been caused by a single clone, USA300. USA300 secretes Panton-Valentine leukocidin (PVL) toxin, which is associated with highly virulent infections. METHODS We sequenced the PVL genes of 174 S. aureus isolates from a global clinical sample. We combined phylogenetic reconstruction and protein modeling methods to analyze genetic variation in PVL. RESULTS Nucleotide variation was detected at 12 of 1726 sites. Two PVL sequence variants, the R variant and the H variant, were identified on the basis of a substitution at nt 527. Of sequences obtained in the United States, 96.7% harbor the R variant, whereas 95.6% of sequences obtained outside the United States harbor the H variant; 91.3% of MRSA isolates harbor the R variant, and 91.3% of methicillin-susceptible strains harbor the H variant. A molecular model of PVL shows 3 mechanisms by which the amino acid substitution may affect PVL function. CONCLUSIONS All sampled PVL genes appear to share a recent common ancestor and spread via a combination of clonal expansion and horizontal transfer. US isolates harbor a variant of PVL that is strongly associated with MRSA infections. Protein modeling reveals that this variant may have functional significance. We propose a hypothesis for the origin of USA300.
Rounding via Trees : Deterministic Approximation Algorithms forGroup

Most optimization problems on an undirected graph reduce in complexity when restricted to instances on a tree. A recent result [3] for probabilistically approximating graph metrics by trees such that no edge stretches (in an expected sense) by more than a factor of O(log n) has resulted in several approximation algorithms which exploit the ease of solving problems on trees. The tree construction in [3] is inherently randomized and a natural question to ask is whether approximation algorithms which use this construction can be derandomized. We present a general framework for derandomizing approximation algorithms which use the above tree construction as a primitive. Let be a graph optimization problem which can be expressed as an integer program with 0-1 variables x(e) for each edge and with an objective function expressible as Supported by a Stanford Graduate Fellowship, an ARO MURI Grant DAAH04-96-1-0007 and NSF Award CCR-9357849, with matching funds from IBM, Schlumberger Foundation, Shell Foundation, and Xerox Corporation. Email: moses@cs.stanford. edu. Supported by an IBM Cooperative Fellowship, an ARO MURI Grant DAAH04-96-1-0007 and NSF Award CCR-9357849, with matching funds from IBM, Schlumberger Foundation, Shell Foundation, and Xerox Corporation. Email: chekuri@cs.stanford. edu. zSupported by Center for Telecommunications at Stanford, ARO Grants DAAH04-95-1-0121/ DAAG55-97-1-0221, and NSF Grants CCR9304971/ CCR9307045. Email: agoel@cs.stanford. edu. Supported by an ARO MURI Grant DAAH04-96-1-0007 and NSF Award CCR-9357849, with matching funds from IBM, Schlumberger Foundation, Shell Foundation, and Xerox Corporation. Email: sudipto@cs.stanford. edu. P e2E x(e) c(e). Given an optimal solution to LP relaxation of the integer program, we show that we can map the solution to a tree approximation of the graph with at most an O(logn log logn) blow-up in the value of the objective function. This can then be coupled with a deterministic LP rounding procedure on the tree to obtain a completely deterministic approximation algorithm for . We apply this framework to the group Steiner tree problem, the k-median problem and the minimum communication cost spanning tree problem. We obtain the rst deterministic approximation algorithms for these problems which match the best known randomized approximations. To do this, we design novel deterministic schemes to round the LP solution for these problems on trees. For the group Steiner tree problem we obtain an approximation ratio of O(log n log k log logn), and for the k-median problem we obtain a ratio of O(log k log log k). We believe that our rounding procedure on trees for the group Steiner tree problem is of independent interest.
Gestational Choriocarcinoma Presenting with Lacrimal Gland Metastasis: A First Reported Case

Background. Gestational choriocarcinoma (GC) is a recognized clinicopathological subtype of gestational trophoblastic neoplasia that usually metastasizes hematogenously to highly vascular organs like the lung, liver, and brain. However, orbital metastasis to the choroid and lacrimal gland is a rare occurrence. Case Presentation. A 21-year-old female presented with headache and left orbital swelling one year after resection of a complete hydatidiform mole followed by adjuvant methotrexate chemotherapy. A metastatic imaging screening revealed multiple metastases in the lungs, brain, and adrenal gland, in addition to the choroid and lacrimal gland. Based on her modified WHO risk factors scoring she was started on chemotherapy and whole brain radiotherapy, which resulted in a complete response. At two-year follow-up, serum b-HCG level was with normal limits; imaging surveillance was uneventful. Conclusion. We present the first case of lacrimal gland metastasis in a young girl from GC relapse.
Toward Precise PLRU Cache Analysis

Schedulability analysis for hard real-time systems requires bounds on the execution times of its tasks. To obtain useful bounds in the presence of caches, cache analysis is mandatory. The subject-matter of this article is the static analysis of the tree-based PLRU cache replacement policy (pseudo least-recently used), for which the precision of analyses lags behind those of other policies. We introduce the term subtree distance, which is important for the update behavior of PLRU and closely linked to the peculiarity of PLRU that allows cache contents to be evicted in “logarithmic time”. Based on an abstraction of subtree distance, we define a must-analysis that is more precise than prior ones by excluding spurious logarithmic-time eviction.
Quantitative Assessment of Circulatory Changes in the Fetal Aortic Isthmus During Progressive Increase of Resistance to Umbilical Blood Flow

BackgroundThis study investigated the effects of impairment to placental flow on flow patterns through the aortic isthmus because in the fetus, this vascular segment is the link between the parallel vascular systems perfused by the left and right ventricles. Methods and ResultsA progressive increase in resistance to blood flow through the placenta was created in seven exteriorized fetal lambs by mechanical umbilical vein compression. Blood flows were measured in the ascending aorta, pulmonary artery, aortic isthmus, and umbilical artery at baseline and at each compression level. The severity of the levels of compression was determined by changes in the flow profile through the umbilical artery. An increase in placental resistance causing a fall in umbilical blood flow of approximately 50% was associated with a retrograde diastolic flow through the aortic isthmus even though the diastolic flow through the umbilical artery remained forward. Because of the systolic predominance, however, the net flow in the isthmus was forward. With a more severe increase in placental resistance corresponding to a decrease of 75% in umbilical blood flow, the net flow through the isthmus approached zero. A strong positive correlation was found between the umbilical blood flow and the net flow through the aortic isthmus (r=.89). ConclusionsVariations in Doppler blood flow velocity waveforms and integrals of the aortic isthmus can be used as a sensitive indicator of the state of the umbilical circulation.
Dual mechanism of vascular endothelial growth factor upregulation by hypoxia in human hepatocellular carcinoma

BACKGROUND/AIMS Vascular endothelial growth factor (VEGF) plays a key role in regulation of tumour associated angiogenesis. In the current study we analysed expression of VEGF and its receptors in human hepatocellular carcinoma (HCC) and investigated the molecular mechanisms of VEGF regulation by hypoxia. METHODS VEGF, kinase domain region (KDR)/fetal liver kinase 1 (flk-1), and flt-1 expression were examined by immunohistochemistry and in situ hybridisation in 15 human HCC tissues. Expression of VEGF and regulation by hypoxia were assessed in three human HCC cell lines using a quantitative competitive reverse transcription-polymerase chain reaction, ELISA, and a series of 5′ deletion reporter gene constructs of the human VEGF promoter in transient transfection assays. RESULTS We observed over expression of VEGF mRNA and protein in HCC compared with cirrhosis or normal liver. Expression of VEGF in tumour cells was strongly increased in areas directly adjacent to necrotic/hypoxic regions. Both VEGF receptors were detected in vascular endothelia of HCC while only KDR/flk-1 receptors were detected in endothelial cells of cirrhotic livers. Expression of VEGF was observed in all human HCC cell lines examined. Hypoxia (1% oxygen) resulted in profound upregulation of VEGF mRNA and protein levels. Furthermore, hypoxia treatment resulted in a doubling of VEGF mRNA stability. Deletion analysis of the human VEGF 5′ flanking region −2018 and +50 demonstrated induction of VEGF promoter activity under hypoxic conditions which was significantly decreased following deletion of the region −1286 and −789 suggesting a substantial contribution of the −975 putative hypoxia inducible factor 1 binding site to hypoxia mediated transcriptional activation of the VEGF gene. CONCLUSION These data suggest hypoxia as a central stimulus of angiogenesis in human HCC through upregulation of VEGF gene expression by at least two distinct molecular mechanisms: activation of VEGF gene transcription and an increase in VEGF mRNA stability.
Do Alcohol Relapse Episodes During Treatment Predict Long-Term Outcomes? Investigating the Validity of Existing Definitions of Alcohol Use Disorder Relapse.

BACKGROUND The construct of relapse is used widely in clinical research and practice of alcohol use disorder (AUD) treatment. The purpose of this study was to test the predictive validity of commonly appearing definitions of AUD relapse in the empirical literature. METHODS Secondary analyses of data from Project MATCH and COMBINE were conducted using 7 definitions of "relapse" based on drinking quantity within a single drinking episode: any drinking; at least 4/5 drinks for women/men; at least 4.3/7.1 drinks for women/men; at least 6/7 drinks for women/men; at least 6 drinks; at least 7/9 drinks for women/men; and at least 8/10 drinks for women/men. Relapse was used to predict alcohol consumption, related consequences, and nonconsumption outcomes (quality of life, psychosocial functioning) at the end of treatment and up to 1 year posttreatment. RESULTS Regression analyses indicated within-treatment relapse definitions significantly predicted end-of-treatment alcohol consumption and alcohol-related consequences. Heavy drinking definitions were generally more predictive than the any drinking definition, but no single heavy drinking definition was consistently a better predictor of outcomes. Relapse definitions were less predictive of longer-term alcohol-related outcomes and both shorter- and longer-term nonconsumption outcomes, including health and psychosocial functioning. CONCLUSIONS One particular definition of relapse did not consistently stand out as the best predictor. Advances in AUD research may require reconceptualization of relapse as a multifaceted dynamic process and may consider a wider range of relevant behaviors (e.g., health and psychosocial functioning) when examining the change process in individuals with AUD.
SLAM in a dynamic large outdoor environment using a laser scanner

In this research, we propose a method of SLAM in a dynamic large outdoor environment using a laser scanner. Focus are cast on solving two major problems: 1) achieving global accuracy especially in non-cyclical environment, 2) tackling a mixture of data from both dynamic and static objects. Algorithms are developed, where GPS data and control inputs are used to diagnose pose error and guide to achieve a global accuracy; Classification of laser points and objects are conducted not in an independent module but across the processing in a framework of SLAM with moving object detection and tracking. Experiments are conducted using the data from two test-bed vehicles, and performance of the algorithms are demonstrated.
Acoustic monitoring of wildlife in inaccessible areas and automatic detection of bird songs from continuous recordings

4 Introduction . 5 AAARS Description and Functionality . 7 System Components . 8 AAARS Recovery System . 12 Microphone Exposure . 14 Results and system specifications . 16 Discussion . 19 Appendix . 23 Chapter 2: Impact of dialects, song type, and species on classification of full songs extracted from continuous acoustic recordings of five grassland songbird species breeding in the eastern United States . 34 Abstract . 35. 35 Introduction . 36 Acoustic characterization of bird songs . 40
Design of Voltage Tracking Control for DC–DC Boost Converter Via Total Sliding-Mode Technique

In this paper, a total sliding-mode control (TSMC) scheme is designed for the voltage tracking control of a conventional dc-dc boost converter. This control strategy is derived in the sense of Lyapunov stability theorem such that the stable tracking performance can be ensured under the occurrence of system uncertainties. The salient feature of this control scheme is that the controlled system has a total sliding motion without a reaching phase as in conventional sliding-mode control (CSMC). Moreover, the effectiveness of the proposed TSMC scheme is verified by numerical simulations and realistic experimentations, and the advantages of good transient response and robustness to uncertainties are indicated in comparison with a conventional proportional-integral control system and a CSMC scheme.
Crystal structure of 4-(trimethylgermyl)benzoic acid

During synthesis of the corresponding aldehyde, 4-(trimethylgermyl)benzoic acid was obtained as a side-product. It crystallizes with two independent molecules in the asymmetric unit which exhibit slightly different geometries. In the crystal structure, centrosymmetric hydrogen-bonded dimers of the molecular pairs are formed.
Parallel Query Scheduling and Optimization with Time- and Space-Shared Resources

Scheduling query execution plans is a particularly complex problem in hierarchical parallel systems, where each site consists of a collection of local time-shared (e.g., CPU(s) or disk(s)) and space-shared (e.g., memory) resources and communicates with remote sites by message-passing. We develop a general approach to the problem, capturingthe full complexityof schedulingdistributed multi-dimensional resource units for all kinds of parallelism within and across queries and operators. We present heuristic algorithms forvarious forms of the problem, some of which are provably near-optimal. Preliminary experimental results conﬁrm the effectiveness of our approach.
Synchronized and efficient communication system based on Agent-Mediator framework for adaptive mixed reality space

In recent years, various systems in different fields of life have been developed to simulate real world scenarios with interactive virtual environments. In the mixed reality (MR) space, several objects are involved to interact in numerous ways which may lead to inconsistencies. Hence, we designed a cost-effective and robust framework that allows synchronized interaction in real time among different modules of the Adaptive Mixed Reality (AMR) space. The proposed system consists of Agent-Mediator framework. Each smart media agent (SMA) in AMR space has its own data processing, management and visualization units. SMA processes the data received from various input devices and updates the local model by reflecting the immersive contents on media walls. SMA maintains synchronization locally as well as transmits the information and raw-data to the Mediator. The central control system i.e. the Mediator receives data from several SMAs and conducts comparative analysis to select appropriate information. It updates the global model by sharing the synchronized updated status with other SMAs in AMR space. The proposed framework provides a real time interaction with immersive contents in AMR space and adjusts it efficiently to different typology on the basis of user's response.
Sex‐specific effects of COMT Val158Met polymorphism on corpus callosum structure: A whole‐brain diffusion‐weighted imaging study

Genetic polymorphisms play a significant role in determining brain morphology, including white matter structure and may thus influence the development of brain functions. The main objective of this study was to examine the effect of Val158Met (rs4680) polymorphism of Catechol‐O‐Methyltransferase (COMT) gene on white matter connectivity in healthy adults.