Miracle-dz/UniFAR-FTUs huggingface dataset:
A worksite vitality intervention to improve older workers' lifestyle and vitality-related outcomes: results of a randomised controlled trial

Objective To evaluate the effectiveness of a worksite vitality intervention on vigorous physical activity (VPA), fruit intake, aerobic capacity, mental health and need for recovery after work among older hospital workers (ie, 45 years and older). Methods The 6-month intervention was evaluated using a randomised controlled trial design. Workers who were randomised to the intervention group (n=367; control: n=363) received the Vital@Work intervention containing (1) a Vitality Exercise Program (VEP) combined with (2) three visits to Personal Vitality Coach. The VEP consisted of a weekly yoga session, a weekly workout session and weekly unsupervised aerobic exercising. Free fruit was provided at the VEP. Data on the outcome measures were collected (ie, year 2009–2010) at baseline (n=730) and 6 months of follow-up after baseline (n=575) using questionnaires, accelerometers and 2 km walk tests. Effects were analysed according to the intention-to-treat principle with complete cases (n=575) and imputed data (n=730) using linear regression analyses. Additional analyses were performed for high yoga and workout compliance (ie, >mean number of sessions). Results Effects were found for sports activities (β=40.4 min/week, 95% CI 13.0 to 67.7) and fruit intake (β=2.7 pieces/week, 95% CI 0.07 to 4.7) and were stronger for workers with high compliance to yoga (sport: β=49.6 min/week, 95% CI 13.9 to 85.2; fruit: β=3.8 pieces/week, 95% CI 1.1 to 6.4) and workout sessions (sport: β=72.9 min/week, 95% CI 36.1 to 109.8; fruit: β=4.0 pieces/week, 95% CI 1.1 to 6.4). The intervention group lowered their need for recovery, when compared to controls (β=−3.5, 95% CI −6.4 to −0.54), with stronger effects for high workout compliance (β=−5.3, 95% CI −9.3 to −1.3). No effects were found on VPA, aerobic capacity or mental health. Conclusions Implementation of worksite yoga and workout facilities and minimal fruit interventions should be considered by employers to promote transitions into healthier lifestyles and thereby health.
Some Notes on Political Theory and American Indian Values: The Case of the Muscogee Creeks

Deplorant le manque d'interet de la theorie politique pour les mondes amerindiens, l'A. propose quelques reflexions sur l'approche des systemes de valeurs autochtones et de l'importance de leur mise a jour pour la comprehension des systemes et pensees politiques autochtones. A partir de ses recherches sur les Creek Muscogee, il decrit notamment son approche pour la modelisation des systemes de valeurs autochtones.
Generating Test Sequences to Assess the Performance of Elastic Cloud-Based Systems

Elasticity is one of the main features of cloud-based systems (CBSs), where elastic adaptations, such as those to deal with scaling in or scaling out of computational resources, help meet performance requirements under varying workload. There is an industrial need to find configurations of elastic adaptations and workload that could lead to degradation of performance in a CBS, serving possibly millions of users. However, the potentially great number of such configurations poses a challenge: executing and verifying all of them on the cloud can be prohibitively expensive in both, time and cost. We present an approach to model elasticity adaptation due to workload changes as a classification tree model and consequently generate short test sequences of configurations that cover all T-wise interactions between parameters in the model. These test sequences, when executed, help us assess the performance of elastic CBS. Using MongoDB as a case study, test sequences generated by our approach reveal several significant performance degradations.
IL-23 Is Required for Long-Term Control of Mycobacterium tuberculosis and B Cell Follicle Formation in the Infected Lung

IL-23 is required for the IL-17 response to infection with Mycobacterium tuberculosis, but is not required for the early control of bacterial growth. However, mice deficient for the p19 component of IL-23 (Il23a−/−) exhibit increased bacterial growth late in infection that is temporally associated with smaller B cell follicles in the lungs. Cxcl13 is required for B cell follicle formation and immunity during tuberculosis. The absence of IL-23 results in decreased expression of Cxcl13 within M. tuberculosis-induced lymphocyte follicles in the lungs, and this deficiency was associated with increased cuffing of T cells around the vessels in the lungs of these mice. Il23a−/− mice also poorly expressed IL-17A and IL-22 mRNA. These cytokines were able to induce Cxcl13 in mouse primary lung fibroblasts, suggesting that these cytokines are likely involved in B cell follicle formation. Indeed, IL-17RA–deficient mice generated smaller B cell follicles early in the response, whereas IL-22–deficient mice had smaller B cell follicles at an intermediate time postinfection; however, only Il23a−/− mice had a sustained deficiency in B cell follicle formation and reduced immunity. We propose that in the absence of IL-23, expression of long-term immunity to tuberculosis is compromised due to reduced expression of Cxcl13 in B cell follicles and reduced ability of T cells to migrate from the vessels and into the lesion. Further, although IL-17 and IL-22 can both contribute to Cxcl13 production and B cell follicle formation, it is IL-23 that is critical in this regard.
Orbital structure of collisionless merger remnants: on the origin of photometric and kinematic properties of elliptical and S0 galaxies

We present a detailed investigation of the relation between the orbital content of merger remnants and observable properties of elliptical and SO galaxies. Our analysis is based on the statistical sample of collisionless mergers of disc galaxies with different mass ratios and orbital parameters, published by Naab & Burkert. We use the spectral method by Carpintero & Aguilar to determine the orbital content of every remnant and correlate it with its intrinsic shape, and its projected kinematic and photometric properties. We discuss the influence of the bulge component and varying pericentre distances. The classified orbit families are box orbits, minor-axis tubes, inner and outer major-axis tubes and boxlets. In general, box orbits dominate the inner parts of the remnant. Major and minor-axis tubes become dominant at intermediate radii and boxlets at large radii. The two most abundant orbit classes are the minor-axis tubes and the box orbits. Their ratio seems to determine the basic properties of a remnant. On average, the fraction of minor-axis tubes increases by a factor of 2 from a merger mass ratio of 1:1 to 4:1, whereas the fraction of box orbits decreases by 10 per cent. At a given mass the central velocity dispersion of a remnant scales with the ratio of minor-axis tubes to box orbits. Interestingly, the division line between rotational supported systems and pressure supported objects, (υ maj /σ 0 )* = 0.7, turns out to coincide with a box to minor-axis tube ratio of unity. The observed h 3 -υ/σ anticorrelation for ellipticals cannot be reproduced by collisionless merger remnants. We propose that this can only be reconciled by an additional physical process that significantly reduces the box orbit content. Remnants that are dominated by minor-axis tube orbits have predominantly discy projections. Boxy remnants have always a box to minor-axis tube ratio larger than one. This study will enable us to identify observed ellipticals that could have formed, in the collisionless limit, by gas-poor disc mergers. In addition, it demonstrates how observable properties of spheroidal stellar systems are connected with their intrinsic orbital structure.
A Feature Type Classification for Therapeutic Purposes: A Preliminary Evaluation with Non-Expert Speakers

We propose a feature type classification thought to be used in a therapeutic context. Such a scenario lays behind our need for a easily usable and cognitively plausible classification. Nevertheless, our proposal has both a practical and a theoretical outcome, and its applications range from computational linguistics to psycholinguistics. An evaluation through inter-coder agreement has been performed to highlight the strength of our proposal and to conceive some improvements for the future.
Fused Lasso Additive Model

We consider the problem of predicting an outcome variable using p covariates that are measured on n independent observations, in a setting in which additive, flexible, and interpretable fits are desired. We propose the fused lasso additive model (FLAM), in which each additive function is estimated to be piecewise constant with a small number of adaptively chosen knots. FLAM is the solution to a convex optimization problem, for which a simple algorithm with guaranteed convergence to a global optimum is provided. FLAM is shown to be consistent in high dimensions, and an unbiased estimator of its degrees of freedom is proposed. We evaluate the performance of FLAM in a simulation study and on two datasets. Supplemental materials are available online, and the R package flam is available on CRAN.
Membrane properties and synaptic responses of interneurons located near the stratum lacunosum-moleculare/radiatum border of area CA1 in whole-cell recordings from rat hippocampal slices.

1. The membrane properties and synaptic inputs of interneurons, located at the stratum (s.) lacunosum-moleculare and radiatum border (L-M) of the CA1 region, were examined with the use of current-clamp whole-cell recordings in rat hippocampal slices. 2. Biocytin-labeled L-M interneurons had nonpyramidal somata and aspinous, often beaded, dendrites that arborized in s. lacunosum-moleculare and radiatum, sometimes as far as s. moleculare of the dentate gyrus. Their axon coursed and branched in s. lacunosum-moleculare and radiatum. Axon collaterals were also observed traversing the hippocampal fissure and arborizing in s. moleculare of the dentate gyrus and s. radiatum of the CA3 region. 3. Several membrane properties of interneurons were typically nonpyramidal: they had large input resistances, short-duration action potentials followed by prominent fast afterhyperpolarizations, and responded to hyperpolarizing current pulses with little membrane rectification. L-M interneurons showed significant anodal break responses, and their mean membrane time constant was 33 ms. After-depolarizations elicited by subthreshold depolarizing current pulses were larger in amplitude and decayed more slowly at depolarized than hyperpolarized membrane potentials. 4. The majority of L-M interneurons (35 of 49 cells) were silent at resting membrane potentials, whereas other displayed either spontaneous single action potentials (n = 12) or rhythmic bursts (n = 2). The rhythmic bursts were insensitive to the N-methyl-D-aspartate (NMDA) and non-NMDA excitatory amino acid receptor antagonists, 2-amino-5-phosphonopentanoic acid (AP-5; 50 microM) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; 20 microM), respectively. Both spontaneous single action potentials and burst firing were blocked by membrane hyperpolarization, suggesting that they were intrinsically rather than synaptically generated. 5. L-M interneurons responded with regular sustained firing to depolarizing current pulses at resting membrane potential. However, at more hyperpolarized membrane potentials (near -75 mV), depolarizing current pulses elicited action-potential firing with a delayed onset. This suggests that voltage-sensitive, transient outward currents may be activated in L-M interneurons from hyperpolarized membrane potentials. 6. Electrical stimulation of s. radiatum or lacunosum-moleculare elicited predominantly long-duration excitatory postsynaptic potentials (EPSPs; n = 20 cells), or both EPSPs and inhibitory postsynaptic potentials (IPSPs; n = 17 cells). In most L-M interneurons (35/37), with increasing intensities, up to two action potentials were elicited. Occasionally, larger bursts (3-5 action potentials) were observed (n = 2). 7. The multiphasic components of the synaptic responses became more evident when stimulations were repeated at different membrane potentials. (ABSTRACT TRUNCATED AT 400 WORDS)
BRIEF COMMUNICATIONS Acetylcholine Release from Rat Atria Can Be Regulated through an arAdrenergic Receptor

Isolated superfused rat atria release [H]acetylcholine when depolarized with 57 mM potassium. The depolarization-induced overflow of [H]acetylcholine is markedly inhibited by micromolar concentrations of epinephrine and norepinephrine. The a,-selective adrenergic agonist methoxamine also inhibits tritium overflow, but the «2-selective adrenergic agonist clonidine and the 0-adrenergic agonist isoproterenol do not. Prazosin, an selective «i-adrenergic antagonist, blocks adrenergic inhibition of [H]acetylcholine overflow with a K, of approximately 0.4 nM. Yohimbine has approximately one-hundredth the potency of prazosin for blocking adrenergic inhibition of [H]acetylcholine overflow. [H]Norepinephrine overflow from isolated rat atria is also inhibited by norepinephrine, but this effect is antagonized by yohimbine and not by prazosin. We suggest that the release of acetylcholine from cardiac parasympathetic neurons can be regulated through an «i -adrenergic receptor, and that this mechanism may underly, at least in part, the relative lack of effects of prazosin on heart rate. (Circ Res 56: 763-766, 1985)
The interdigitated back contact solar cell: A silicon solar cell for use in concentrated sunlight

The theoretical and experimental performance of an interdigitated back contact solar cell is described. This type of cell is shown to have significant advantages over a conventional solar cell design when used at high concentration levels, namely, reduced internal series resistance, nonsaturating open-circuit voltage, and an absence of shadowing by front surface contacting fingers. The results of a computer study are presented showing the effects of bulk lifetime, surface recombination velocity, device thickness, contact dimensions, and illumination intensity on the conversion efficiency and general device operation. Experimental results are presented for solar illumination intensities up to 28 W/cm2.
WebSum: Enhanced SumBasic algorithm for Web site summarization

Due to the rapid increase of information in the World Wide Web, there exists an explosion of information on the Web that may overwhelm the common Web user. The Web user may find it quicker or more efficient to browse the Web by reading summaries of Web sites. This paper proposes WebSum to compress Web site content into a summary. WebSum is an enhancement of the SumBasic algorithm, that was mainly used for multi-document summarization. In the case of Web sites, we find that several Web characteristics such as title and keywords can be used to extract sentences that may represent the overall topic of the Web site. Initial results show that WebSum is able to reveal sentences relate to the concept of the Web site. WebSum is then evaluated against the original algorithm of SumBasic.
EVALUATION OF INSULIN RESISTANCE AND OXIDATIVE STRESS IN OBESE PATIENTS WITH POLYCYSTIC OVARY SYNDROME

BACKGROUND : Patient with Polycystic ovary syndrome (PCOS) are known to have high incidence of Insulin Resistance (IR) and oxidative stress and most of the patients are obese. The aim of this study was to evaluate the insulin resistance and oxidative stress in obese PCOS patients. METHODS : 104 obese patients with PCOS [BMI ≥23 Kg/m2] and 95 healthy control subjects were included in this study. Plasma sex steroid hormones, fasting insulin, fasting glucose, were measured in both the groups. Oral glucose tolerance test was also performed. Total antioxidant status (TAS), malonyldialdehyde (MDH), protein carbonylation (PC), erythrocyte reduced gluthathione (GSH) and antioxidant enzymes like erythrocyte catalase and erythrocyte glutathione peroxidase (GPx) activity were measured. Insulin resistance was evaluated by using homeostasis model assessment for insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI) and fasting glucose / fasting insulin ratio (fasting G:I ratio). RESULTS : Compared with healthy women, those with obese PCOS had significantly elevated HOMA-IR, plasma MDA, protein carbonylation, erythrocyte glutathione peroxidase activity and significantly decreased QUICKI, fasting G:I ratio, plasma TAS, GSH, catalase activity. CONCLUSION: The result of the present study indicates, high level of insulin resistance and significantly increased oxidative stress were observed in obese PCOS patients when compared with controls
Unilateral Absence of Plantaris muscle in Ethiopian Cadavers – a case report

Plantaris is the largest muscle in mammals other than primates. It runs alongside the gastrosoleus complex, and continues along the medial aspect of the Achilles tendon (AT) before inserting onto the greater tuberosity of the calcaneus. The plantaris muscle is vestigial in human beings and has much clinical importance. It is known to present several anatomical variations in terms of its occurrence, origin, course, relation with surrounding neurovascular structures and insertion. It may be absent unilaterally or bilaterally. The plantaris muscle is absent in 7–10% of the human population. Two such variations were observed unilaterally in the present report in which absence of the right plantaris muscle were seen in the right lower limb of the two cadavers. Despite its vestigial nature, injury to plantaris muscle can present a diagnostic challenge among clinicians and radiologists. Surgical importance of the muscle lies in successful use of its tendon for reconstructive surgery. Therefore, Knowledge of anatomical variations of the plantaris muscle is important for physiotherapists, plastic surgeons performing tendon transfer operations, clinicians diagnosing muscle tears and radiologists interpreting MRI scans.
Prospective Associations Between Early Long-Term Household Tobacco Smoke Exposure and Subsequent Indicators of Metabolic Risk at Age 10.

INTRODUCTION Although there are established risks associated with gestational tobacco smoke exposure, few studies have addressed the metabolic hazards of domestic exposure in early childhood. This study prospectively examines the long-term relationship between early childhood exposure to household smoke and two adiposity-related measures at age 10. METHODS Participants from the Quebec Longitudinal Study of Child Development birth cohort were categorized into one of three groups of early childhood household exposure to tobacco smoke over four time points (from ages 1 to 7 years): never-exposed; transient exposure; and continuous exposure. Follow-up measures of body mass index and waist circumference were independently assessed at age 10. RESULTS Compared to being never exposed, transient and continuous household smoke exposure predicted increases of 0.93 cm (95% confidence interval [CI] between 0.05 and 1.82 cm; P = .03) and 1.56 cm (95% CI between 0.07 and 3.05 cm; P = .04) in children's waist circumference, respectively. Children exposed to transient and continuous household smoke, compared to unexposed children, also showed 0.48 and 0.81 point increases in their body mass index, respectively, both Ps = . 005. Once adjusted, for confounding variables, only transient household smoke remained associated with 43% greater odds of belonging to the overweight/obese category (95% CI between 1.12 and 1.81 cm; P < .01). CONCLUSIONS We found significant long-term prospective associations between home-based secondhand smoke exposure and unhealthy body fat distribution. Waist circumference in youth has become an important risk factor for obesity-related diseases in adulthood. Our findings emphasize the importance public health initiatives and parental sensitization aimed at domestic exposure reductions during the critical early childhood years.
Bone marrow chimerism as a strategy to produce tolerance in solid organ allotransplantation

Purpose of reviewClinical transplant tolerance has been most successfully achieved combining hematopoietic chimerism with kidney transplantation. This review outlines this strategy in animal models and human transplantation, and possible clinical challenges. Recent findingsKidney transplant tolerance has been achieved through chimerism in several centers beginning with Massachusetts General Hospital's success with mixed chimerism in human leukocyte antigen (HLA)-mismatched patients and the Stanford group with HLA-matched patients, and the more recent success of the Northwestern protocol achieving full chimerism. This has challenged the original view that stable mixed chimerism is necessary for organ graft tolerance. However, among the HLA-mismatched kidney transplant-tolerant patients, loss of mixed chimerism does not lead to renal-graft rejection, and the development of host Foxp3+ regulatory T cells has been observed. Recent animal models suggest that graft tolerance through bone marrow chimerism occurs through both clonal deletion and regulatory immune cells. Further, Tregs have been shown to improve chimerism in animal models. SummaryAnimal studies continue to suggest ways to improve our current clinical strategies. Advances in chimerism protocols suggest that tolerance may be clinically achievable with relative safety for HLA-mismatched kidney transplants.
Silent Information Regulator 2&agr;, a Longevity Factor and Class III Histone Deacetylase, Is an Essential Endogenous Apoptosis Inhibitor in Cardiac Myocytes

Yeast silent information regulator 2 (Sir2), a nicotinamide adenine dinucleotide–dependent histone deacetylase (HDAC) and founding member of the HDAC class III family, functions in a wide array of cellular processes, including gene silencing, longevity, and DNA damage repair. We examined whether or not the mammalian ortholog Sir2 affects growth and death of cardiac myocytes. Cardiac myocytes express Sir2&agr; predominantly in the nucleus. Neonatal rat cardiac myocytes were treated with 20 mmol/L nicotinamide (NAM), a Sir2 inhibitor, or 50 nmol/L Trichostatin A (TSA), a class I and II HDAC inhibitor. NAM induced a significant increase in nuclear fragmentation (2.2-fold) and cleaved caspase-3, as did sirtinol, a specific Sir2 inhibitor, and expression of dominant-negative Sir2&agr;. TSA also modestly increased cell death (1.5-fold) but without accompanying caspase-3 activation. Although TSA induced a 1.5-fold increase in cardiac myocyte size and protein content, NAM reduced both. In addition, NAM caused acetylation and increases in the transcriptional activity of p53, whereas TSA did not. NAM-induced cardiac myocyte apoptosis was inhibited in the presence of dominant-negative p53, suggesting that Sir2&agr; inhibition causes apoptosis through p53. Overexpression of Sir2&agr; protected cardiac myocytes from apoptosis in response to serum starvation and significantly increased the size of cardiac myocytes. Furthermore, Sir2 expression was increased significantly in hearts from dogs with heart failure induced by rapid pacing superimposed on stable, severe hypertrophy. These results suggest that endogenous Sir2&agr; plays an essential role in mediating cell survival, whereas Sir2&agr; overexpression protects myocytes from apoptosis and causes modest hypertrophy. In contrast, inhibition of endogenous class I and II HDACs primarily causes cardiac myocyte hypertrophy and also induces modest cell death. An increase in Sir2 expression during heart failure suggests that Sir2 may play a cardioprotective role in pathologic hearts in vivo.
Analisys of Kazakhstan satellite images by distributed system Hadoop

This work is devoted to application of Hadoop distributed system to analyze information of Kazakhstan Satellite images. Describes how satellite images can be acquired from NASA web servers and detailed description of image processing using OpenCV library. Short conclusions are provided from realized analysis experiments on various region of Kazakhstan. In the end, shown comparison of running analysis algorithms using Google Cloud Engine with various number of working nodes.