Miracle-dz/UniFAR-FTUs huggingface dataset:
The slip history of the 1994 Northridge, California, earthquake determined from strong-motion, teleseismic, GPS, and leveling data

We present a rupture model of the Northridge earthquake, determined from the joint inversion of near-source strong ground motion recordings, P and SH teleseismic body waves, Global Positioning System (GPS) displacement vectors, and permanent uplift measured along leveling lines. The fault is defined to strike 122° and dip 40° to the south-southwest. The average rake vector is determined to be 101°, and average slip is 1.3 m; the peak slip reaches about 3 m. Our estimate of the seismic moment is 1.3 ± 0.2 × 1026 dyne-cm (potency of 0.4 km3). The rupture area is small relative to the overall aftershock dimensions and is approximately 15 km along strike, nearly 20 km in the dip direction, and there is no indication of slip shallower than about 5 to 6 km. The up-dip, strong-motion velocity waveforms are dominated by large S-wave pulses attributed to source directivity and are comprised of at least 2 to 3 distinct arrivals (a few seconds apart). Stations at southern azimuths indicate two main S-wave arrivals separated longer in time (about 4 to 5 sec). These observations are best modeled with a complex distribution of subevents: The initial S-wave arrival comes from an asperity that begins at the hypocenter and extends up-dip and to the north where a second, larger subevent is centered (about 12 km away). The secondary S arrivals at southern azimuths are best fit with additional energy radiation from another high slip region at a depth of 19 km, 8 km west of the hypocenter. The resolving power of the individual data sets is examined by predicting the geodetic (GPS and leveling) displacements with the dislocation model determined from the waveform data, and vice versa, and also by analyzing how well the teleseismic solution predicts the recorded strong motions. The general features of the geodetic displacements are not well predicted from the model determined independently from the strong-motion data; likewise, the slip model determined from geodetic data does not adequately reproduce the strong-motion characteristics. Whereas a particularly smooth slip pattern is sufficient to satisfy the geodetic data, the strong-motion and teleseismic data require a more heterogeneous slip distribution in order to reproduce the velocity amplitudes and frequency content. Although the teleseismic model can adequately reproduce the overall amplitude and frequency content of the strong-motion velocity recordings, it does a poor job of predicting the geodetic data. Consequently, a robust representation of the slip history and heterogeneity requires a combined analysis of these data sets.
Copy number loss of variation_91720 in PIK3CA predicts risk of esophageal squamous cell carcinoma.

PURPOSE Esophageal squamous cell carcinoma (ESCC) is one of the most fatal cancers worldwide. However, the etiology is complex and unclear. 3q26 harboring abundant oncogenes have been identified as the loci of ESCC susceptibility. In the present study, we examined whether CNVs on 3q26 would be associated with the risk, TNM stage and prognosis of ESCC. METHODS Variation_91720 in phosphatidylinositol 3-kinase catalytic subunit (PIK3CA) and Variation_91733 in sex-determining region Y-box 2 overlapping transcript (SOX2OT) were selected for investigation. The study included 204 ESCC patients and 208 healthy controls. The copy number of the selected sites and mRNA was detected by real-time fluorescence quantitative polymerase chain reaction and calculated using the CopyCaller v2.0 software program. RESULTS The copy number distribution of Variation_91720 was significantly different in ESCC cases and matched controls (p<0.001). Copy number loss of Variation_91720 may increase the risk of ESCC (OR=6.217, 95% CI=3.117-12.400; adjusted OR =6.251, 95% CI=3.130-12.428). PIK3CA mRNA expression was higher in tumor tissue (P=0.0003) and increased with the copy number gain of Variation_91720. CONCLUSION Our findings suggest that copy number loss of Variation_91720 in PIK3CA predicts risk of ESCC, which might serve as a biomarker that for early diagnosis of ESCC.
OUTCOMES RESEARCH IN MEDICAL REHABILITATION: A Primer and Introduction to a Series

This article presents basic findings, concepts and methods in medical outcomes research. Epidemiologic outcomes research begins with the daily life of patients or populations and searches for antecedents. Clinical outcomes research begins with an intervention and examines effects. Both are needed. Issues and methodologies in medical rehabilitation outcomes research are examined, and topics for the forthcoming series are sketched. Medical rehabilitation can make substantial advances in understanding its effectiveness in the near future if it will undertake the needed comparative outcomes research
Assembly of the Cardiac Intercalated Disk during Pre- and Postnatal Development of the Human Heart

Background In cardiac muscle, the intercalated disk (ID) at the longitudinal cell-edges of cardiomyocytes provides as a macromolecular infrastructure that integrates mechanical and electrical coupling within the heart. Pathophysiological disturbance in composition of this complex is well known to trigger cardiac arrhythmias and pump failure. The mechanisms underlying assembly of this important cellular domain in human heart is currently unknown. Methods We collected 18 specimens from individuals that died from non-cardiovascular causes. Age of the specimens ranged from a gestational age of 15 weeks through 11 years postnatal. Immunohistochemical labeling was performed against proteins comprising desmosomes, adherens junctions, the cardiac sodium channel and gap junctions to visualize spatiotemporal alterations in subcellular location of the proteins. Results Changes in spatiotemporal localization of the adherens junction proteins (N-cadherin and ZO-1) and desmosomal proteins (plakoglobin, desmoplakin and plakophilin-2) were identical in all subsequent ages studied. After an initial period of diffuse and lateral labelling, all proteins were fully localized in the ID at approximately 1 year after birth. Nav1.5 that composes the cardiac sodium channel and the gap junction protein Cx43 follow a similar pattern but their arrival in the ID is detected at (much) later stages (two years for Nav1.5 and seven years for Cx43, respectively). Conclusion Our data on developmental maturation of the ID in human heart indicate that generation of the mechanical junctions at the ID precedes that of the electrical junctions with a significant difference in time. In addition arrival of the electrical junctions (Nav1.5 and Cx43) is not uniform since sodium channels localize much earlier than gap junction channels.
Is there a relationship between admission blood glucose level following acute poisoning and clinical outcome?

Introduction The aim of this study was to investigate the relationship between the admission blood glucose level following acute poisoning, severity of acute poisoning and clinical outcome. Material and methods This prospective study was conducted on 345 deliberate self-poisoning patients. Standard demographic and clinical information; admission blood glucose level; poisoning severity score and outcome were recorded. Patients with a history of diabetes mellitus, receipt of pre-sampling intravenous dextrose solution or glucocorticoids, and poisoning with toxic agents which produce hyper- or hypoglycaemia were excluded. Results Mean age of the patients was 27.5 ±8.6 years. Females outnumbered males (57.9%). Oral ingestion of more than one drug (46.7%) and opiates (14.2%) were the main causes of poisoning. Blood glucose values ranged from 50 mg/dl to 396 mg/dl. Hyper- and hypoglycaemia were observed in 23.8% and 13.91% respectively. A total of 24.41% and 22.92% of the patients in hyper- and hypoglycaemic groups had grade 3 and 4 severity score in comparison with 4.18% in the normoglycaemic group. Development of complications and death were 14.64% and 10.42% in patients with hyper- and hypoglycaemia versus 3.73% in patients with normoglycaemia. A significant difference between normoglycaemic and hyperglycaemic patients in the severity of poisoning and clinical outcome was observed (P < 0.001). Conclusions Admission blood glucose levels may have a relationship with the severity of poisoning and clinical outcome following acute poisoning.
Searching for gravitational waves from binary inspirals with LIGO

We describe the current status of the search for gravitational waves from inspiralling compact binary systems in LIGO data. We review the result from the first scientific run of LIGO (S1). We present the goals of the search of data taken in the second scientific run (S2) and describe the differences between the methods used in S1 and S2.
Dynamic Warp Resizing in High-Performance SIMT

Modern GPUs synchronize threads grouped in a warp at every instruction. These results in improving SIMD efficiency and makes sharing fetch and decode resources possible. The number of threads included in each warp (or warp size) affects divergence, synchronization overhead and the efficiency of memory access coalescing. Small warps reduce the performance penalty associated with branch and memory divergence at the expense of a reduction in memory coalescing. Large warps enhance memory coalescing significantly but also increase branch and memory divergence. Dynamic workload behavior, including branch/memory divergence and coalescing, is an important factor in determining the warp size returning best performance. Optimal warp size can vary from one workload to another or from one program phase to the next. Based on this observation, we propose Dynamic Warp Resizing (DWR). DWR takes innovative microarchitectural steps to adjust warp size during runtime and according to program characteristics. DWR outperforms static warp size decisions, up to 1.7X to 2.28X, while imposing less than 1% area overhead. We investigate various alternative configurations and show that DWR performs better for narrower SIMD and larger caches.
Gate delay estimation in STA under dynamic power supply noise

This paper presents a gate delay estimation method that takes into account dynamic power supply noise. We review STA based on static IR-drop analysis and a conventional method for dynamic noise waveform, and reveal their limitations and problems that originate from circuit structures and higher delay sensitivity to voltage in advanced technologies. We then propose a gate delay computation that overcomes the problems with iterative computations and consideration of input voltage drop. Evaluation results with various circuits and noise injection timings show that the proposed method estimates path delay fluctuation well within 2% error on average.
Développement des habiletés linguistiques chez les enfants porteurs d'un implant cochléaire

This dissertation examines language development in children who received a cochlear implant (CI) at a young age. A systematic review studied the main outcomes reported in the literature concerning vocabulary and grammar development of profoundly deaf children who received a CI before the age of 3 years. A total of 28 studies met inclusion criteria. Studies varied widely in participant characteristics, assessment tools, study designs, and overall methodological quality. A descriptive synthesis and a metaanalysis were completed separately for each language domain (receptive and expressive vocabulary and grammar). Results showed a positive impact of cochlear implantation on language development, but only a minority of children achieved language levels on par with their hearing age-mates. The majority of the children involved in the primary studies continued to exhibit varying levels of delay in receptive and expressive vocabulary and grammar after up to 5 years of cochlear implant use. Results showed that the minority of children who achieved language levels on par with hearing children were likely to have received their implant by the age of two, thus suggesting that age at implantation influences language achievement. A second study examined receptive and expressive vocabulary and grammar achievement of 27 French-speaking children who received a CI between the age of 8 and 28 months. Standardized measures were administered and the language levels attained by children with CIs were compared with those of the normative sample of same-age hearing peers for each measure. As a group, children exhibited language levels within normal limits on all standardized language measures. Examination of individual patterns in a subgroup of children revealed 4 different language profiles: a) normal language levels in all domains, b) general language delay, c) vocabulary within the norm with morphosyntactic delay, and d) an atypical profile (discrepancies across language domains). In three of these profiles, comprehension of sentences was impaired. Findings suggest that receiving a cochlear
CMU System Combination for WMT‘09

This paper describes the CMU entry for the system combination shared task at WMT'09. Our combination method is hypothesis selection, which uses information from n-best lists from several MT systems. The sentence level features are independent from the MT systems involved. To compensate for various n-best list sizes in the workshop shared task including first-best-only entries, we normalize one of our high-impact features for varying sub-list size. We combined restricted data track entries in French - English, German - English and Hungarian - English using provided data only.
Gallager mapping based constellation shaping for LDPC-coded modulation systems

This paper focuses on the signal constellation shaping in LDPC coded modulation system. A novel constellation is presented by combining geometric shaping with probabilistic shaping based on quadrature amplitude modulation (QAM)constellation. With the shaped signal constellation, the signal mapping is optimized by using the extrinsic information transfer (EXIT) chart analysis. We further consider the nonbinary LDPC coded-modulation by combining with the proposed constellation shaping. Numerical results reveal that the proposed constellation can get the shaping gain without increasing the complexity of detection.
Targeted Induction of Lung Endothelial Cell Apoptosis Causes Emphysema-like Changes in the Mouse

Pulmonary gas exchange relies on a rich capillary network, which, together with alveolar epithelial type I and II cells, form alveolar septa, the functional units in the lung. Alveolar capillary endothelial cells are critical in maintaining alveolar structure, because disruption of endothelial cell integrity underlies several lung diseases. Here we show that targeted ablation of lung capillary endothelial cells recapitulates the cellular events involved in cigarette smoke-induced emphysema, one of the most prevalent nonneoplastic lung diseases. Based on phage library screening on an immortalized lung endothelial cell line, we identified a lung endothelial cell-binding peptide, which preferentially homes to lung blood vessels. This peptide fused to a proapoptotic motif specifically induced programmed cell death of lung endothelial cells in vitro as well as targeted apoptosis of the lung microcirculation in vivo. As early as 4 days following peptide administration, mice developed air space enlargement associated with enhanced oxidative stress, influx of macrophages, and up-regulation of ceramide. Given that these are all critical elements of the corresponding human emphysema caused by cigarette smoke, these data provide evidence for a central role for the alveolar endothelial cells in the maintenance of lung structure and of endothelial cell apoptosis in the pathogenesis of emphysema-like changes. Thus, our data enable the generation of a convenient mouse model of human emphysema. Finally, combinatorial screenings on immortalized cells followed by in vivo targeting establishes an experimental framework for discovery and validation of additional ligand-directed pharmacodelivery systems.
Long-term results from a randomized phase II trial of standard- versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT.

PURPOSE The outcome of patients diagnosed with advanced gastrointestinal stromal tumor (GIST) and treated long-term with imatinib mesylate is unknown. A previous report of a randomized phase II trial of imatinib mesylate in patients with incurable GIST detailed high response rates at both the 400 and the 600 mg/d dose levels. We conducted a long-term analysis of patients treated on the trial, including patients followed during an extension phase, to evaluate survival, patterns of failure, and potential prognostic factors, including tumor mutational status. PATIENTS AND METHODS Patients with advanced GIST were enrolled onto an open-label, multicenter trial and were randomly assigned (1:1) to receive imatinib 400 versus 600 mg/d. Data were prospectively collected on KIT mutational status, total tumor area, and other potential prognostic factors. Patients were followed for a median of 63 months. RESULTS One hundred forty-seven patients were enrolled: 73 were in arm A (imatinib 400 mg/d), and 74 were in arm B (imatinib 600 mg/d). Response rates, median progression-free survival, and median overall survival were essentially identical on both arms, and median survival was 57 months for all patients. Forty-one patients overall (28%) remained on the drug long-term. Female sex, the presence of an exon 11 mutation, and normal albumin and neutrophil levels were independently associated with better survival. CONCLUSION Nearly 50% of patients with advanced GIST who were treated with imatinib mesylate survived for more than 5 years, regardless of a 400 or 600 mg/d starting dose.
Household expansion linked to agricultural intensification during emergence of Hawaiian archaic states

The Leeward Kohala Field System (LKFS) covering ∼60 km2 on Hawai‘i Island is one of the world's best-studied archaeological examples of preindustrial agricultural intensification. Archaeological correlates for households over a 400-y period of intensification of the LKFS (A.D. 1400–1800) indicate that household age, number, and distribution closely match the expansion of agricultural features at both macro- and microscales. We excavated and dated residential complexes within portions of five traditional Hawaiian land units (ahupua‘a), two in the central core of the field system and three in the southern margins. Forty-eight radiocarbon dates from 43 residential features indicate an overall pattern of exponential increase in the numbers of households over time. Spatial distribution of these dates suggests that the core of the LKFS may have reached a population saturation point earlier than in the southern margins. Bayesian statistical analysis of radiocarbon dates from residential features in the core region, combined with spatial analysis of agricultural and residential construction sequences, demonstrates that the progressive subdivision of territories into smaller socioeconomic units was matched by addition of new residences, probably through a process of household fissioning. These results provide insights into the economic processes underlying the sociopolitical transformation from chiefdom to archaic state in precontact Hawai‘i.
Language Development: Form and Function in Emerging Grammars

The research reported is in investigation into the early acquisition of grammar by three children from the age of approximately 19 months. Nonlinguistic information from situational and behavioral context was used to infer the semantic intent of utterances in order to analyze the development of linguistic expression. Previous psycholinguistic studies of child language had described utterances in terms of the orderly distribution with which words occurred in juxtaposition. In this study, by making judgments of semantic intent, it was possible to describe the inherent structure of utterances so that conclusions could be drawn about the child's knowledge of semantic-syntactic relationship in the derivation of sentences. For example, when the child said "Mommy sock" and Mommy was putting the child's sock on the child, it was clear that a different semantic interpretation was intended than when the child said "Mommy sock" and picked up Mommy's sock. The syntactic components of generative transformational grammars were proposed for those samples of the children's language in which mean length of utterance was less than 1.5 morphemes.For the psychologist, the book provides added insight into the relative development of syntactic expression and underlying cognitive function. It was clear, for example, that the two did not develop hand in hand. For the linguist, the book provides additional evidence for the growing conclusion that child language is not incoherent. There is strong evidence presented to demonstrate the extent (and limitations) of the child's knowledge of basic grammatical relations in the earliest two-word utterances. For the speech pathologist concerned with language disorders in children, the evidence presented and the resulting conclusions should provide important hypotheses for application in treatment.One of the major contributions that this book will make to the literature on child language is the presentation of a large body of data in support of the conclusions that have been drawn. There is an extensive catalog of the children's earliest two-word utterances, negative sentences, and syntactic and single-word lexicons. This evidence should prove invaluable to other researchers in the field.
The clash of evaluations

Purpose – The main purpose of this paper is to examine more closely the tension between, on the one hand, forms of internal school improvement based on internal evaluation measures and, on the other hand, control and legitimisation needs grounded on external evaluation measures.Design/methodology/approach – The clash of these forms of evaluation is at the core of the paper, dealing in particular with the changing evaluation systems in the Cypriot education system. Therefore, the case study approach is utilised here. More specifically, the case of Cyprus is used as a system under transition in order to move from a primarily teacher inspection system, which is externally driven, to a combination of a teacher/school inspection system, which is based on both external and internal processes and is directed at both formative and summative evaluation processes.Findings – It is asserted that the new proposed appraisal system for Cyprus addresses the deficiencies of the current evaluation system and generally aims.