Metformin Prescription for Insured Adults With Prediabetes

Background—Prediabetes affects 1 in 3 Americans. Both intensive lifestyle intervention and metformin can prevent or delay progression to diabetes. Over the past decade, lifestyle interventions have been translated across various settings, but little is known about the translation of evidence surrounding metformin use. Objective—To examine metformin prescription for diabetes prevention and patient characteristics that may affect metformin prescription. Requests for Single Reprints: Tannaz Moin, MD, MBA, MSHS, David Geffen School of Medicine at University of California, Los Angeles, Division of General Internal Medicine and Health Services Research, 911 Broxton Avenue, Los Angeles, CA 90024; tmoin@mednet.ucla. edu. Current Author Addresses: Dr. Moin: David Geffen School of Medicine at University of California, Los Angeles, Division of General Internal Medicine and Health Services Research, 911 Broxton Avenue, Los Angeles, CA 90024. Drs. Duru and Mangione, Ms. Li, and Mr. Turk: David Geffen School of Medicine at University of California, Los Angeles, 10940 Wilshire Boulevard, Suite 700, Los Angeles, CA 90095. Dr. Ettner: David Geffen School of Medicine at University of California, Los Angeles, Division of General Internal Medicine and Health Services Research, 911 Broxton Plaza, Room 106, Box 951736, Los Angeles, CA 90095. Ms. Keckhafer: UnitedHealthcare, PO Box 1459, Minneapolis, MN 55440. Dr. Ho: UnitedHealthcare, 5995 Plaza Drive, Cypress, CA 90630. Disclaimer: The findings and conclusions in this manuscript are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention (CDC) or the National Institutes of Health (NIH). Drs. Moin and Mangione had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Disclosures: Disclosures can be viewed at www.acponline. org/authors/icmje/ConflictOfInterestForms.do? msNum=M14-1773. Reproducible Research Statement: Study protocol: A version with redacted confidential information is available to approved persons through written agreement with the authors (e-mail, tmoin@mednet.ucla.edu). Statistical code: Available through written agreement with the authors (e-mail, tmoin@mednet.ucla.edu). Data set: Not available due to confidentiality agreements between the academic and health plan partners. Author Contributions: Conception and design: T. Moin, S. Ettner, S. Ho, C.M. Mangione. Analysis and interpretation of the data: T. Moin, J. Li, O.K. Duru, S. Ettner, N. Turk, A. Keckhafer, S. Ho, C.M. Mangione. Drafting of the article: T. Moin. Critical revision of the article for important intellectual content: T. Moin, J. Li, O.K. Duru, S. Ettner, A. Keckhafer, S. Ho, C.M. Mangione. Final approval of the article: T. Moin, O.K. Duru, S. Ettner, A. Keckhafer, C.M. Mangione. Provision of study materials or patients: T. Moin, A. Keckhafer, S. Ho. Statistical expertise: S. Ettner, N. Turk. Obtaining of funding: O.K. Duru, S. Ettner, C.M. Mangione. Administrative, technical, or logistic support: S. Ho, C.M. Mangione. Collection and assembly of data: J. Li, N. Turk, A. Keckhafer, S. Ho. HHS Public Access Author manuscript Ann Intern Med. Author manuscript; available in PMC 2015 December 17. Published in final edited form as: Ann Intern Med. 2015 April 21; 162(8): 542–548. doi:10.7326/M14-1773. A uhor M anscript