Miracle-dz/UniFAR-FTUs huggingface dataset:
A Risk Taking Routing Algorithm for Delay Tolerant Networks

Delay Tolerant Networks (DTNs) suffer from frequent disruptions and partitioning. Because of dynamic environment and lack of knowledge about the whole network topology, routing is quiet challenging in DTNs. Prediction based algorithms in DTNs are able to predict nodes future contacts in the case where each node has a movement model. In this paper we are going to propose a risk taking routing algorithm, which differs from previous algorithms in predicting the future contacts and waiting for those nodes instead of forwarding to the currently in contact good forwarders. Considering the forwarding strategy as an online problem, we evaluate the algorithm using a risk reward competitive analysis. Simulation results show that our algorithm performs much better than PROPHET which is a base to our algorithm. The results also show that the optimum risk value is 2 which results in best performance.
Testing the Work Environment Hypothesis of Bullying on a Group Level of Analysis: Psychosocial Factors as Precursors of Observed Workplace Bullying

The present paper scrutinises the work environment hypothesis of bullying by examining relationships between psychosocial factors at work and bullying within departments on a group level of analysis, as compared to the many studies executed on an individual level of analysis. Relationships between quantitative demands, job control, role demands, leadership behaviour and social climate, and observed bullying were studied in a convenience sample consisting of 276 departments with a total of 4,064 respondents. Between‐group bivariate correlations showed relatively strong relationships (r > .52) between the predictors social climate, leadership behaviour, and role demands, respectively, and observed bullying in the department. A two‐factor higher‐level model was formulated for the independent variables yielding two latent factors reflecting an interpersonal domain and a task‐oriented domain, where the former was strongly associated with observed bullying at a group level of analysis (Beta =−.73), while the last factor yielded an insignificant contribution. The results confirm that a poor social work environment exists within departments in which bullying takes place, hence, yielding further support to the work environment hypothesis. In line with the present results, future studies on workplace bullying should include a group level of analysis.
Preliminary Study on Norovirus, Hepatitis A Virus, Escherichia coli and their Potential Seasonality in Shellfish from Different Growing and Harvesting Areas in Sardinia Region

Edible lamellibranch molluscs can be involved in foodborne disease and infections of varying severity. They are filter feeding animals able to retain and concentrate in their organism bacteria, parasites, viruses and biotoxins marine algae present in their external environment. Major shellfish harvesting and relaying areas from different areas in Sardinia region were defined and studied by analysing different physicochemical parameters in the water and the levels of Escherichia coli (E. coli), Norovirus (NoVs) genogroup I (NoVGI), NoVs genogroup II (NoVGII) and hepatitis A virus (HAV) in the shellfish harvested and farmed from 2009 to 2011. During that period the identification of the viral agents was carried out by one step real-time reverse transcriptase-polymerase chain reaction and Escherichia coli according to ISO TS 16649-3:2005 standard method. A total of 1266 shellfish samples were tested for NoVGI, NoVGII, HAV and faecal indicators. Norovirus contamination was found in 337 samples (26.6%); only one sample of mussels was positive for HAV (0.08%); while E. coli prevalence was 3.8% in shellfish. The probability of observing shellfish samples positive for NoVs, HAV and E. coli presence was associated with harvesting, growing and relaying areas, period of sampling, environmental parameters, animal species (P<0.05). Although the higher prevalence rate of human enteropathogenic viruses was found in the winter period, we did not observe a significant relationship between the effect of seawater temperature (seasonality) and NoVs presence all over the study period; in fact, according to statistical analysis, the presence of human enteric viruses does not appear to be related to water temperature.
Relation of prophylactic medication to the occurrence of early seizures following craniocerebral trauma.

✓ In a series of 1614 cases of combat head injury incurred in Vietnam between 1967 and 1970, 70% received prophylatic anticonvulsant medication (diphenylhydantoin, 300 to 400 mg/day); 36 developed fits in the first week following injury. The prophylactic regimen had no recognizable effect. Therapeutic serum levels of anticonvulsants are not achieved for 2 or 3 weeks. Usefulness of dexamethasone in controlling brain swelling may be seriously impaired by diphenylhydantoin. Thus prophylaxis against early posttraumatic fits may not be practical or desirable.
Effects of Endogenous d-Alanine Synthesis and Autoinhibition of Bacillus anthracis Germination on In Vitro and In Vivo Infections

ABSTRACT Bacillus anthracis transitions from a dormant spore to a vegetative bacillus through a series of structural and biochemical changes collectively referred to as germination. The timing of germination is important during early steps in infection and may determine if B. anthracis survives or succumbs to responsive macrophages. In the current study experiments determined the contribution of endogenous d-alanine production to the efficiency and timing of B. anthracis spore germination under in vitro and in vivo conditions. Racemase-mediated production of endogenous d-alanine by B. anthracis altered the kinetics for initiation of germination over a range of spore densities and exhibited a threshold effect wherein small changes in spore number resulted in major changes in germination efficiency. This threshold effect correlated with d-alanine production, was prevented by an alanine racemase inhibitor, and required l-alanine. Interestingly, endogenous production of inhibitory levels of d-alanine was detected under experimental conditions that did not support germination and in a germination-deficient mutant of B. anthracis. Racemase-dependent production of d-alanine enhanced survival of B. anthracis during interaction with murine macrophages, suggesting a role for inhibition of germination during interaction with these cells. Finally, in vivo experiments revealed an approximately twofold decrease in the 50% lethal dose of B. anthracis spores administered in the presence of d-alanine, indicating that rates of germination may be directly influenced by the levels of this amino acid during early stages of disease.
Ieee Transactions on Instrumentation and Measurement 1 Adc Standard Iec 60748-4-3: Precision Measurement of Alternative Enob without a Sine Wave

— A practical analog-to-digital converter (ADC) introduces quantization error in excess of the ideal value and one way of expressing this is by comparing the value of this error with that of an ideal ADC. This comparison is known as the effective number of bits (ENOBs). It is accepted practice to measure ENOB using the signal-to-noise and distortion (SINAD) ratio of a sine-wave input. This paper extends ENOB theory to any arbitrary waveform by including the crest factor of the input signal. It is now possible to apply the ENOB concept to wideband systems. Measuring the SINAD of an arbitrary or multitone waveform with precision normally requires the use of laboratory standard test equipment. However, International Electrotechnical Commission standard 60748-4-3 specifies an alternative method for wideband SINAD measurements that may also be suitable for built-in test. It is essentially a multitone test using two pseudorandom signal sources and is sometimes known as the double comb-filter (DCF) method. This paper demonstrates the requirements for a practical implementation of a DCF-based system for measuring an ENOB of up to 24 bits. It is shown that in a practical application, DCF ENOB and sine-wave ENOB results have similar levels of accuracy, but in the presence of amplitude nonlinearity the differing test signal amplitude weightings cannot fundamentally produce the same ENOB figure. It is shown that DCF ENOB is more representative of communications system performance and therefore extends the use of ENOB to wideband applications.
NONCONTINGENT REINFORCEMENT: AN INAPPROPRIATE DESCRIPTION OF TIME-BASED SCHEDULES THAT REDUCE BEHAVIOR

Several articles published recently in the Journal of Applied Behavior Analysis demonstrate that fixed-time (FT) schedules can be used to reduce troublesome behaviors (for a review of these and related articles, see Tucker, Sigafoos, & Bushell, 1998). In the first article in this series, Vollmer, Iwata, Zarcone, Smith, and Mazaleski (1993) demonstrated through functional analysis that the self-injurious behavior of 3 women was maintained by attention. Subsequently, they reduced the self-injurious behavior of those women by delivering attention under an FT schedule. They referred to the FT schedule as a noncontingent reinforcement procedure, and the name unfortunately has stuck. For example, in the most recent article in the series, Carr, Bailey, Ecot, Lucker, and Weil (1998) indicate that ‘‘In a noncontingent reinforcement (NCR) procedure, the reinforcer responsible for maintaining a problem behavior is delivered on a fixed-time (FT) or variable-time schedule’’ (p. 313). It is standard practice in behavior analysis to define reinforcement functionally, that is, as an operation or process in which the occurrence of a behavior is followed by a change in the environment (reinforcer) and as a result such behavior subsequently increases in rate, or is otherwise strengthened (e.g., Catania, 1991; Chance, 1998; Miltenberger, 1997). Operations that have other effects characteristically are not referred to as reinforcement. If this convention is followed, delivery of attention under an FT schedule did not constitute reinforcement in
The systemic inflammatory response syndrome in acute liver failure

The systemic inflammatory response syndrome (SIRS) in acute liver failure (ALF), in which infection is common, has not been studied. In this study, SIRS components were recorded on admission and during episodes of infection, in 887 ALF patients admitted to a single center during an 11‐year period. Overall, 504 (56.8%) patients manifested a SIRS during their illness, with a maximum of 1, 2, and 3 concurrent SIRS components in 166, 238, and 100 patients, respectively. In 353 (39.8%) patients who did not become infected, a SIRS on admission was associated with a more critical illness, subsequent worsening of encephalopathy, and death. Infected patients more often developed a SIRS and one of greater magnitude. The magnitude of the SIRS in 273 patients with bacterial infection correlated with mortality, being 16.7%, 28.4%, 41.2%, and 64.7% in patients with 0, 1, 2, and 3 maximum concurrent SIRS components, respectively. Similar correlations with mortality were seen for SIRS associated with fungal infection, bacteremia, and bacterial chest infection. Fifty‐nine percent of patients with severe sepsis died, as did 98% of those with septic shock. A significant association was found between progressive encephalopathy and infection. Infected patients with progressive encephalopathy manifested more SIRS components than other infected patients. For patients with a SIRS, the proportions of infected and noninfected patients manifesting worsening encephalopathy were similar. In ALF, the SIRS, whether or not precipitated by infection, appears to be implicated in the progression of encephalopathy, reducing the chances of transplantation and conferring a poorer prognosis.
Cerebrospinal fluid biomarkers for differentiation of frontotemporal lobar degeneration from Alzheimer's disease

Accurate ante mortem diagnosis in frontotemporal lobar degeneration (FTLD) is crucial to the development and implementation of etiology-based therapies. Several neurodegenerative disease-associated proteins, including the major protein constituents of inclusions in Alzheimer's disease (AD) associated with amyloid-beta (Aβ1−42) plaque and tau neurofibrillary tangle pathology, can be measured in cerebrospinal fluid (CSF) for diagnostic applications. Comparative studies using autopsy-confirmed samples suggest that CSF total-tau (t-tau) and Aβ1−42 levels can accurately distinguish FTLD from AD, with a high t-tau to Aβ1−42 ratio diagnostic of AD; however, there is also an urgent need for FTLD-specific biomarkers. These analytes will require validation in large autopsy-confirmed cohorts and face challenges of standardization of within- and between-laboratory sources of error. In addition, CSF biomarkers with prognostic utility and longitudinal study of CSF biomarker levels over the course of disease are also needed. Current goals in the field include identification of analytes that are easily and reliably measured and can be used alone or in a multi-modal approach to provide an accurate prediction of underlying neuropathology for use in clinical trials of disease modifying treatments in FTLD. To achieve these goals it will be of the utmost importance to view neurodegenerative disease, including FTLD, as a clinicopathological entity, rather than exclusively a clinical syndrome.
Throughput scaling laws of hybrid wireless networks with proximity preference

Recent studies suggest nodes in practical networks are more likely to communicate with nearby nodes than far away nodes, which is referred to as proximity preference. In this paper, we model proximity preference by assuming the probability of communication follows a power law distribution with respect to distance and analyze its influence on the throughput of a hybrid network. Moreover, L-maximum-hop routing strategy is adopted to enforce delay constraints. Throughput is derived as a function of maximum hop L, proximity preference index α and the number of base stations (BSs) m. It is also found that per-node throughput changes with α. When 0 ≤ α ≤ 2, proximity has no influence on throughput. When 2 ≤ α ≤ 3, the throughput increases with α. Otherwise, the throughput reaches its maximum and remains constant. Our results demonstrate the interplay of various networks parameters with proximity preference and provide guidelines for the design of practical networks.
Iterative Receiver Design with Joint Channel Estimation and Synchronization for Coded MIMO-OFDM over Doubly Selective Channels

The paper introduces a turbo (iterative) receiver design for joint channel estimation, synchronization and soft decoding in convolutional-coded multiple-input multiple-output (MIMO) orthogonal frequency division multiplexing (OFDM) systems over timeand frequency-selective (doubly selective) channels. Employing the complex-exponential basis expansion model (CE-BEM) for representing doubly selective channels, a maximum likelihood (ML) objective function of carrier frequency offset (CFO) and MIMO time-varying channel responses (BEM coefficients) is formulated to develop a semiblind ML framework for joint time-variant channel estimation and synchronization. To reduce the overhead of pilot signals without sacrificing estimation accuracy, the soft bit information from a soft-input soft-output (SISO) decoder is exploited in computing soft estimates of data symbols to be functioned as pilots for further enhancing the estimation accuracy after CFO and channel acquisition phase (initial coarse estimation) using pilots. In other words, the resulting semi-blind ML estimation scheme operates in conjunction with soft decoding process in a (iteratively) progressive manner to exploit remarkable gains of turbo processing (iterative extrinsic information exchange). Simulation results show that the proposed turbo joint channel estimation and synchronization scheme offers high estimation accuracy that approaches Cramér-Rao lower bounds (CRLBs) over a wide range of CFO values under low signal-to-noise ratio (SNR) conditions.
Advances in Prostate Cancer Chemotherapy: A New Era Begins 1

Prostate cancer continues to be the most common lethal malignancy diagnosed in American men and the second leading cause of male cancer mortality. Over 60 years ago, Huggins and Hodges discovered androgen deprivation as a first‐line therapy for metastatic prostate cancer, which leads to remissions typically lasting 2 to 3 years, but in most men prostate cancer ultimately progresses to an androgen‐independent state resulting in death due to widespread metastases. Multiple mechanisms of androgen independence have now been documented, including amplification of the androgen receptor as well as signal transduction pathways that bypass the androgen receptor completely. In 2004, two landmark studies demonstrated a survival advantage in androgen‐independent prostate cancer patients utilizing docetaxel chemotherapy, setting a new standard of care for this disease. In addition, treatments with the bisphosphonate zoledronic acid and systemic radioisotopes have also been shown to have palliative benefits in this population. Building on these advances, several new traditional chemotherapeutic agents as well as new targeted therapies are under development.
A superionic state in nano-porous double-layer capacitors: insights from Monte Carlo simulations.

Recently observed anomalous properties of ionic-liquid-based nanoporous supercapacitors [C. Largot et al., J. Am. Chem. Soc. , 2008, 130, 2730-2731] have attracted much attention. Here we present Monte Carlo simulations of a model ionic liquid in slit-like metallic nanopores. We show that exponential screening of the electrostatic interactions of ions inside a pore, as well as the image-charge attraction of ions to the pore surface, lead to the 'anomalous' increase of the capacitance with decreasing the pore width. The simulation results are in good agreement with the experimental data. The capacitance as a function of voltage is almost constant for low voltages and vanishes above a certain threshold voltage. For very narrow pores, these two regions are separated by a peak. With increase of the pore size the peak turns into a bump and disappears for wide pores. This effect, related to a specific character of the voltage-induced filling of nanopores with counterions at high densities, is yet to be verified experimentally.
Testosterone activates sexual dimorphism including male-typical carotenoid but not melanin plumage pigmentation in a female bird

ABSTRACT In males it is frequently testosterone (T) that activates the expression of sexually selected morphological and behavioral displays, but the role of T in regulating similar traits in females is less clear. Here, we combine correlational data with results from T and gonadotropin-releasing hormone (GnRH) manipulations in both sexes to assess the role of T in mediating sexually dimorphic coloration and morphology in the red-backed fairy-wren (Malurus melanocephalus). We show that: (1) natural variation in female expression of ornamental traits (darkened bills and red back feathers) is positively associated with age and circulating androgen titres, (2) females have the capacity to express most male-typical traits in response to exogenous T, including carotenoid-pigmented body plumage, shorter feathers, darkened bill and enlarged cloacal protuberance, but (3) appear constrained in production of male-typical melanin-pigmented plumage, and (4) low androgen levels during the pre-nuptial molt, probably because of low ovarian capacity for steroid production (or luteinizing hormone sensitivity), prevent females from developing male-like ornamentation. Thus, females appear to retain molecular mechanisms for hormonally regulated male-typical ornamentation, although these are rarely activated because of insufficient production of the hormonal signal. Highlighted Article: Female red-backed fairy-wrens express male-typical traits in response to exogenous and endogenous testosterone, including carotenoid-pigmented plumage, darkened bill and an enlarged sperm storage organ, but are constrained in production of melanin-pigmented plumage.
Daily Rhythm of Luciferin Activity in Gonyaulax polyedra

Extracts prepared from Gonyaulax cells harvested late in the 12-hour dark period of an artificial 24-hour day contain as much as four times more luciferin activity than similar extracts prepared during the light period. If cultures are not treated with heat or light to reduce the flashing associated with handling, the time of maximum activity is obscured.
Formation Process of Autophagosome Is Traced with Apg8/Aut7p in Yeast

We characterized Apg8/Aut7p essential for autophagy in yeast. Apg8p was transcriptionally upregulated in response to starvation and mostly existed as a protein bound to membrane under both growing and starvation conditions. Immunofluorescence microscopy revealed that the intracellular localization of Apg8p changed drastically after shift to starvation. Apg8p resided on unidentified tiny dot structures dispersed in the cytoplasm at growing phase. During starvation, it was localized on large punctate structures, some of which were confirmed to be autophagosomes and autophagic bodies by immuno-EM. Besides these structures, we found that Apg8p was enriched on isolation membranes and in electron less-dense regions, which should contain Apg8p-localized membrane- or lipid-containing structures. These structures would represent intermediate structures during autophagosome formation. Here, we also showed that microtubule does not play an essential role in the autophagy in yeast. The result does not match with the previously proposed role of Apg8/Aut7p, delivery of autophagosome to the vacuole along microtubule. Moreover, it is revealed that autophagosome formation is severely impaired in the apg8 null mutant. Apg8p would play an important role in the autophagosome formation.
Studies on Starling's Law of the Heart: IX. The Effects of Impeding Venous Return on Performance of the Normal and Failing Human Left Ventricle

The acute circulatory responses to impeding venous return to the heart by the inflation of a balloon in the inferior vena cava were determined in 14 patients undergoing left heart catheterization. In the five patients without clinical or hemodynamic evidence of impaired left ventricular function, left ventricular end-diastolic pressure fell, and the decrease was accompanied by reductions in the cardiac index, left ventricular stroke volume, and left ventricular stroke work. In nine patients with impaired left ventricular function, directionally similar responses were noted, although the left ventricular function curves relating left ventricular end-diastolic pressure to left ventricular stroke work were generally flatter and lower than those in the patients without left ventricular disease. In none of the patients did a significant increase in cardiac index, stroke volume, or left ventricular stroke work occur during inflation of the balloon. It is concluded that the Starling relationship appears to operate in a directionally similar manner both in the normal and the depressed human left ventricle, and that the left ventricles of patients with impaired function are not on a descending limb of the curve. However, a descending limb of the left ventricular Starling curve may become apparent when an additional work load is imposed on the diseased ventricle.
A Look at Hopes and Worries About Marriage

Abstract The present study examined hopes and worries about marriage, following a parental divorce, among a sample of 238 adolescents (age 11-17). The current study improves upon existing research by obtaining a more representative sample of adolescents who had experienced a parental divorce within the past two years, utilizing open-ended questions, and focusing on adolescents' attitudes about their own future marriages (rather than marriage in general). Findings partially support past research indicating that children of divorce may be anxious about their own marital future-but also indicate that there are many hopes for marriage, and that there may be considerable diversity within this population.