Miracle-dz/UniFAR-FTUs huggingface dataset:
85nm gate length enhancement and depletion mode InSb quantum well transistors for ultra high speed and very low power digital logic applications

We demonstrate for the first time 85nm gate length enhancement and depletion mode InSb quantum well transistors with unity gain cutoff frequency, fT, of 305 GHz and 256 GHz, respectively, at 0.5V VDS, suitable for high speed, very low power logic applications. The InSb transistors demonstrate 50% higher unity gain cutoff frequency, fT, than silicon NMOS transistors while consuming 10 times less active power
A simple randomized algorithm for sequential prediction of ergodic time series

We present a simple randomized procedure for the prediction of a binary sequence. The algorithm uses ideas from previous developments of the theory of the prediction of individual sequences. We show that if the sequence is a realization of a stationary and ergodic random process then the average number of mistakes converges, almost surely, to that of the optimum, given by the Bayes predictor. The desirable finite-sample properties of the predictor are illustrated by its performance for Markov processes. In such cases the predictor exhibits near-optimal behavior even without knowing the order of the Markov process. Prediction with side information is also considered.
Using multiple segmentations for image auto-annotation

Automatic image annotation techniques that try to identify the objects in images usually need the images to be segmented first, especially when specifically annotating image regions. The purpose of segmentation is to separate different objects in images from each other, so that objects can be processed as integral individuals. Therefore, annotation performance is highly influenced by the effectiveness of segmentation. Unfortunately, automatic segmentation is a difficult problem, and most of the current segmentation techniques do not guarantee good results. A multiple segmentations algorithm is proposed by Russell et al. [12] to discover objects and their extent in images. In this paper, we explore the novel use of multiple segmentations in the context of image auto-annotation. It is incorporated into a region based image annotation technique proposed in previous work, namely the training image based feature space approach. Three different levels of segmentations were generated for a 5000 image collection. Experimental results show that image auto-annotation achieves better performance when using all three segmentation levels together than using any single one on its own.
On the computational power of DNA annealing and ligation

In [20] it was shown that the DNA primitives of Separate, Merge, and Amplify were not sufficiently powerful to invert functions defined by circuits in linear time. Dan Boneh et al [4] show that the addition of a ligation primitive, Append, provides the missing power. The question becomes, "How powerful is ligation? Are Separate, Merge, and Amplify necessary at all? " This paper proposes to informally explore the power of annealing and ligation for DNA computation. We conclude, in fact, that annealing and ligation alone are theoretically capable of universal computation.
Design and implementation of the real-time GIS data model and Sensor Web service platform for environmental big data management with the Apache Storm

An abstract real-time GIS data model and Sensor Web service platform was proposed to manage real-time environmental data. With the development of sensor technology, more and more sensor networks are deployed to monitor our environment, and then generate environmental big data. How to improve the real-time GIS data model and Sensor Web service platform for real-time environmental big data manage is a problem. In this paper, the Apache Storm is adopted to deal with the question. A design and implementation of the real-time GIS data model and Sensor Web service platform for environmental big data management with Apache Storm is proposed. The main studied contents include integrating the Apache Strom with the Sensor Web service as the Sensor Observation Service, and processing the environmental big data timely. To test the feasibility of the design and implementation, two use cases of real-time air quality monitoring and real-time soil moisture monitoring based on the real-time GIS data model in the Sensor Web service platform are realized and demonstrated. The experimental results show that the implementation of real-time GIS data model and Sensor Web Service Platform with the Apache Storm is an effective way to manage real-time environmental big data.
alpha-Tubulin limits its own synthesis: evidence for a mechanism involving translational repression

A Chinese hamster alpha-tubulin cDNA was modified to encode an 11-amino acid carboxyl-terminal extension containing the immunodominant epitope from influenza hemagglutinin antigen (to create HA alpha 1-tubulin) and was cloned into a vector for expression in mammalian cells. 12 stable CHO cell lines expressing this HA alpha 1-tubulin were isolated and characterized. HA alpha 1-tubulin incorporated into all classes of microtubules, assembled to the same extent as the endogenous tubulin, and did not perturb the growth of the cells in which it was expressed. However, overexpression of HA alpha 1-tubulin strongly repressed the synthesis of endogenous alpha-tubulin while having little or no effect on the synthesis of beta-tubulin. Treatment of transfected cells with sodium butyrate to induce even greater expression of HA alpha 1-tubulin led to a further decrease in synthesis of endogenous alpha-tubulin that was fully reversible upon removal of the inducer. Decreased synthesis of alpha-tubulin in transfected cells did not result from decreased levels of alpha-tubulin mRNA, as demonstrated by ribonuclease protection assays. On the other hand, colchicine, a drug previously shown to destabilize the tubulin message, caused a clear reduction in both protein synthesis and mRNA levels for transfected HA alpha 1- tubulin and endogenous alpha-tubulin, thus indicating that the decreased alpha-tubulin synthesis observed as a result of HA alpha 1- tubulin overexpression is distinct from the previously described autoregulation of tubulin. The results are consistent with a mechanism in which free alpha-tubulin inhibits the translation of its own message as a way of ensuring stoichiometric synthesis of alpha- and beta- tubulin.
Advances in endoscopic management of biliary tract complications after liver transplantation

Biliary tract complications after liver transplantation (LT) most commonly include biliary leaks, strictures, and stone disease. Living donor recipients and donation after cardiac death recipients are at an increased risk of developing biliary complications. Biliary leaks usually occur early after transplantation, whereas strictures and stone disease occur later. The diagnosis of biliary complications relies on a combination of clinical presentation, laboratory abnormalities, and imaging modalities. Biliary leaks are usually diagnosed on the basis of bilious output from a surgical drain, fluid collections on imaging, or a cholescintigraphy scan demonstrating a leak. Magnetic resonance cholangiopancreatography (MRCP) is noninvasive, does not require the administration of an intravenous contrast agent, and provides detailed imaging of the entire biliary system both above and below the anastomosis. The latter not only helps in the diagnosis of biliary strictures and stones before patients undergo invasive procedures such as endoscopic retrograde cholangiopancreatography (ERCP) but also allows treating physicians to plan the optimal treatment approach. MRCP has, therefore, replaced invasive therapeutic modalities such as ERCP as the modality of choice for the diagnosis of biliary strictures and stones. There have been significant advances in endoscopic accessories, including biliary catheters, wires, and stents, as well as endoscopic technologies such as overtube‐assisted endoscopy over the last decade. These developments have resulted in almost all patients, including those with difficult strictures or altered surgical anatomies (eg, Roux‐en‐Y hepaticojejunostomy), being treated via an endoscopic approach with percutaneous transhepatic cholangiography, which is more invasive and associated with significant morbidity, with surgery being reserved for a small minority of patients. Advances in the diagnosis and endoscopic management of patients with biliary complications after LT are discussed in this review. Liver Transpl 19:482–498, 2013. © 2013 AASLD.
Curcumin and Boswellia serrata Modulate the Glyco-Oxidative Status and Lipo-Oxidation in Master Athletes

Background: Chronic intensive exercise is associated with a greater induction of oxidative stress and with an excess of endogenous advanced glycation end-products (AGEs). Curcumin can reduce the accumulation of AGEs in vitro and in animal models. We examined whether supplementation with curcumin and Boswellia serrata (BSE) gum resin for 3 months could affect plasma levels of markers of oxidative stress, inflammation, and glycation in healthy master cyclists. Methods. Forty-seven healthy male athletes were randomly assigned to Group 1, consisting of 22 subjects given a Mediterranean diet (MD) alone (MD group), and Group 2 consisted of 25 subjects given a MD plus curcumin and BSE (curcumin/BSE group). Interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), high-sensitivity c-reactive protein (hs-CRP), total AGE, soluble receptor for AGE (sRAGE), malondialdehyde (MDA), plasma phospholipid fatty acid (PPFA) composition, and non-esterified fatty acids (NEFA) were tested at baseline and after 12 weeks. Results: sRAGE, NEFA, and MDA decreased significantly in both groups, while only the curcumin/BSE group showed a significant decline in total AGE. Only the changes in total AGE and MDA differed significantly between the curcumin/BSE and MD groups. Conclusions. Our data suggest a positive effect of supplementation with curcumin and BSE on glycoxidation and lipid peroxidation in chronically exercising master athletes.
Spindle‐cell rhabdomyosarcoma of the thumb: Rare site, rare tumor in a child

Spindle‐cell rhabdomyosarcoma (RMS) is a relatively recently recognized favorable variant of embryonal RMS occurring mainly in the paratesticular and head and neck regions. Cytological reports of spindle‐cell RMS have been sparse in the literature and the awareness of its cytological features is not very wide among cytopathologists.
Perfect versus imperfect monitoring in multi-agent opportunistic channel access

This paper investigates the impact of imperfect information on the performance of secondary users (SU) attempting to opportunistically exploit spectrum resources in a distributed manner. We design two channel selection strategies that leverage different levels of information about past channel activity. In the case of perfect monitoring we assume each SU is able to distinguish signals transmitted by a primary user (PU) from signals transmitted by an SU and collision events. In the case of imperfect monitoring we assume SUs to be unable of discriminating between SU or PU activity in the channel. We formally prove that both strategies converge to a static orthogonal channel allocation. Our simulation results show that the impact of imperfect information is to reduce the rate of convergence; the performance loss depends on the level of PU activity and on the amount of competition between SUs.
Pitfalls in a discovery: the chronicle of chloroquine.

It is traditional in this Society that the Presi dent deliver an address at the annual banquet. In line with that tradition, I have chosen to discuss one facet of that patriarch of human dis easeâ€”malaria. The facet I have selected is the chronicle of the antimalarial drug, chioroquine a true story tinged with an element midway between romance and intrigue. In view of the recent public interest in drugs for human con sumption, this story is timely; it has not been recounted before. Practically all of the world's regular supply of quinine was denied to the Allies following the Japanese invasion of Pearl Harbor in December 1941. This was a most serious loss for it was apparent that a long war lay ahead and that much of it would have to be fought in highly malarious areas. This country moved immediately to meet the emergency. The War Production Board (on April 4, 1942) issued Conservation Order M-131 which took quinine off the market and re stricted its use almost completely to the treat ment of malaria. At the same time, an appeal was made to those who held supplies of the alkaloid to deposit them with the War Produc tion Board. The response was excellent and a large supply of cinchona alkaloids was acquired for purely military needs. The National Research Council was apprised of the fact that a usable mixture of the total alkaloids of quinine, known as totaquine, could be prepared. After an investigation, that body recommended the use of totaquine as a quinine substitute. In another move, the War Production Board undertook to stimulate production of Atabrinet
Phishing in the system of systems settings: mobile technology

The immense growth in mobile technology has opened various opportunities, both in marketing and in M-Commerce applications. The growth in these applications is according to the system of systems concept through which technologies such as cell phone networks are becoming integrated with other systems such as the Internet. Unfortunately, this may also lead to a new security risk, the use of mobile technology, more specifically the distribution of short message service (SMS) messages, to conduct phishing attacks. We demonstrate four types of phishing activities that can take place via mobile technology and provide a specific example on one of the introduced types.
Optimizing treatments for nicotine dependence by increasing cognitive performance during withdrawal

Introduction: Current FDA-approved smoking cessation pharmacotherapies have limited efficacy and are associated with high rates of relapse. Therefore, there is a clear need to develop novel antismoking medications. Nicotine withdrawal is associated with cognitive impairments that predict smoking relapse. It has been proposed that these cognitive deficits are a hallmark of nicotine withdrawal that could be targeted in order to prevent smoking relapse. Thus, pharmacotherapies that increase cognitive performance during nicotine withdrawal may represent potential smoking cessation agents. Areas covered: The authors review the clinical literature demonstrating that nicotine withdrawal is associated with deficits in working memory, attention and response inhibition. They then briefly summarize different classes of compounds and strategies to increase cognitive performance during nicotine withdrawal. Particular emphasis has been placed on translational research in order to highlight areas for which there is strong rationale for pilot clinical trials of potential smoking cessation medications. Expert opinion: There is emerging evidence that supports deficits in cognitive function as a plausible nicotine withdrawal phenotype. The authors furthermore believe that the translational paradigms presented here may represent efficient and valid means for the evaluation of cognitive-enhancing medications as possible treatments for nicotine dependence.
Object detection and classification in surveillance system

Object Detection and Tracking in Surveillance System is inevitable in the present scenario, as it is not possible for a person to continuously monitor the video clips in real time. We propose an efficient and novel system for detecting moving objects in a surveillance video and predict whether it is a human or not. In order to account for faster object detection, we use an established Background Subtraction Algorithm known as Mixture of Gaussians. A set of simple and efficient features are extracted and provided to Support Vector Machine. The performance of the system is evaluated with different kernels of SVM and also for K Nearest Neighbor Classifier with its various distance metrics. The system is evaluated using statistical measurements, and the experiments resulted in average F measure of 86.925% and thus prove the efficiency of the novel system.
Noninvasive Assessment of Left Atrial Function by Strain Rate Imaging in Patients with Hypertension: A Possible Beneficial Effect of Renin-Angiotensin System Inhibition on Left Atrial Function

To the Editor: I read with great interest the study by Dr. Kokubu et al. (1), which showed that the mean systolic strain rate (SR) of left atrial (LA) segments (SR-LAs) in a dilated LA group and non–dilated LA group was significantly lower than that in normotensive (NT) subjects, irrespective of the presence or absence of left ventricular hypertrophy (LVH); that the mean SR-LAs in hypertensive (HT) patients was lower than that in NT subjects; that the mean SR-LAs in a non–dilated LA group administered renin angiotensin system (RAS) inhibitors was equivalent to that in NT subjects; and that in HT patients, the mean SR-LAs, as an index of LA reservoir function, decreased before development of LA enlargement and LVH. These results suggested that treatment with RAS inhibitors preserves LA reservoir function in HT patients without dilated LA, and that SR imaging can detect LA dysfunction in HT patients and is useful for evaluation of the therapeutic benefit on LA reservoir function. The methods and interpretation of the results, however, raise several concerns. Kokubu et al. (1) report that 80 patients with HT were studied, in whom relevant history included hypercholesterolaemia, diabetes, and paroxysmal atrial fibrillation, which could affect LA systolic or diastolic function. Despite this fact, the relations of these diseases to LA systolic or diastolic function were not well described. This raises the question: was there any relation between these aspects of the patient histories and the results of this study? In addition, the HT patients had greater body mass index (BMI) than did the NT patients, which could have affected LA systolic or diastolic function. However, Kokubu et al. (1) did not adequately describe the relation of BMI to LA systolic or diastolic function. Here again, did the relation between BMI and these functions affect the results?
Variable-to-fixed length codes are better than fixed-to-variable length codes for Markov sources

It is demonstrated that for finite-alphabet, kth-order ergodic Markov sources (i.e. memory of k letters), a variable-to-fixed length code is better than the best fixed-to-variable length code (Huffman code). It is shown how to construct a variable-to-fixed length code for a kth order ergodic Markov source, which compresses more effectively than the best fixed-to-variable code. >
A fast algorithm for multi-group multicast beamforming in large-scale wireless systems

Multi-group multicast beamforming in wireless systems with large antenna arrays and massive audience is investigated in this paper. Multicast beamforming design is a well-known non-convex quadratically constrained quadratic programming (QCQP) problem. A recent attempt is to apply convex-concave procedure (CCP) to find a stationary solution, whose complexity, however, increases dramatically as the problem size increases. In this paper, we propose a low-complexity highperformance algorithm for multi-group multicast beamforming design in large-scale wireless systems by utilizing the alternating direction method of multipliers (ADMM) together with CCP. In specific, the original non-convex QCQP problem is first approximated by a sequence of convex subproblems via CCP. Each convex subproblem is then reformulated as a novel ADMM form. Our ADMM reformulation enables that each updating step is performed by solving multiple small-size subproblems with closed-form solutions in parallel. Numerical results show that our fast algorithm maintains the same favorable performance as state-of-the-art algorithms but reduces the complexity by orders of magnitude.
A shared reconfigurable VLIW multiprocessor system

In this paper, we present the design and implementation of an open-source reconfigurable very long instruction word (VLIW) multiprocessor system. This processor is implemented as a softcore on a field-programmable gate arrays (FPGA) and its instruction set architecture (ISA) is based on the Lx/ST200 ISA. This multiprocessor design is based on our earlier ρ-VEX processor design. Since the ρ-VEX processor is a parameterized processor, our multiprocessor design is also parameterized. By utilizing a freely available compiler and simulator in our development framework, we are able to optimize our design and map any application written in C to our multiprocessor system. This VLIW multiprocessor can exploit data level as well as instruction level parallelism inherent in an application and make its execution faster. More importantly, we achieve our results by saving expensive FPGA area through the sharing of resources. The results show that we can achieve two times better performance for our dual-processor system (with shared resources) compared to a uni-processor system or a 2-cluster processor system for applications having data level and instruction level parallelism.
Measuring the Value of Information: The Information-Intensive Organization

This paper suggests that firms that successfully integrate an information technology (I/T) strategy with their business strategies do so by focusing on the information itself, rather than on technology, as the real carrier of value and source of competitive advantage. A primary mechanism by which a firm becomes an information-intensive firm is the implementation of a procedure for measuring the value of its information assets V(I). This paper presents a methodology for measuring the value of information in the firm. This paper describes the application of that methodology in an actual case study and discusses some consequences of being able to compare organizations with respect to their relative levels of information intensity.
Wspomaganie rozwoju dzieci w wieku od 5 do 7 lat a ich gotowość do radzenia sobie z wyzwaniami szkoły

W naprzeciw problemom, jakie pojawiły się w dyskursie publicznym związanym z obniżeniem wieku rozpoczynania nauki w szkole, możemy zapytać zarówno o gotowość dzieci pięcioi sześcioletnich do podjęcia nauki szkolnej (Wilgocka-Okoń, 2003), jak i o gotowość szkoły do przyjęcia młodszych niż dotąd dzieci (Brzezińska, 2002). Gotowość dziecka jest dziś najczęściej rozumiana jako efekt interakcji dojrzewania (w kontekście zmian związanych z rozwojem kory przedczołowej), rozwoju pobudzanego przez czynniki środowiskowe oraz aktywności własnej dziecka (Bruner, 2006; Brzezińska, 2004; Filipiak, 2012a; Wygotski, 1971). Gotowość szkoły możemy określić jako wrażliwość instytucji na dynamicznie zmieniające się potrzeby dziecka oraz umiejętność dostosowania warunków, procedur, wymagań i zadań do tych potrzeb.