Miracle-dz/UniFAR-FTUs huggingface dataset:
A Kernel-Based Neural Network Test for High-dimensional Sequencing Data Analysis

The recent development of artificial intelligence (AI) technology, especially the advance of deep neural network (DNN) technology, has revolutionized many fields. While DNN plays a central role in modern AI technology, it has been rarely used in sequencing data analysis due to challenges brought by high-dimensional sequencing data (e.g., overfitting). Moreover, due to the complexity of neural networks and their unknown limiting distributions, building association tests on neural networks for genetic association analysis remains a great challenge. To address these challenges and fill the important gap of using AI in high-dimensional sequencing data analysis, we introduce a new kernel-based neural network (KNN) test for complex association analysis of sequencing data. The test is built on our previously developed KNN framework, which uses random effects to model the overall effects of high-dimensional genetic data and adopts kernel-based neural network structures to model complex genotype-phenotype relationships. Based on KNN, a Wald-type test is then introduced to evaluate the joint association of high-dimensional genetic data with a disease phenotype of interest, considering non-linear and non-additive effects (e.g., interaction effects). Through simulations, we demonstrated that our proposed method attained higher power compared to the sequence kernel association test (SKAT), especially in the presence of non-linear and interaction effects. Finally, we apply the methods to the whole genome sequencing (WGS) dataset from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study, investigating new genes associated with the hippocampal volume change over time.
Can We Learn Communication-Efficient Optimizers?

Communication-efficient variants of SGD, specifically local SGD, have received a great deal of interest in recent years. These approaches compute multiple gradient steps locally, that is on each worker, before averaging model parameters, helping relieve the critical communication bottleneck in distributed deep learning training. Although many variants of these approaches have been proposed, they can sometimes lag behind state-of-the-art adaptive optimizers for deep learning. In this work, we investigate if the recent progress in the emerging area of learned optimizers can potentially close this gap while remaining communication-efficient. Specifically, we meta-learn how to perform global updates given an update from local SGD iterations. Our results demonstrate that learned optimizers can substantially outperform local SGD and its sophisticated variants while maintaining their communication efficiency. Learned optimizers can even generalize to unseen and much larger datasets and architectures, including ImageNet and ViTs, and to unseen modalities such as language modeling. We therefore demonstrate the potential of learned optimizers for improving communication-efficient distributed learning.
AttriHuman-3D: Editable 3D Human Avatar Generation with Attribute Decomposition and Indexing

Editable 3D-aware generation, which supports user-interacted editing, has witnessed rapid development recently. However, existing editable 3D GANs either fail to achieve high-accuracy local editing or suffer from huge computational costs. We propose AttriHuman-3D, an editable 3D human generation model, which address the aforementioned problems with attribute decomposition and indexing. The core idea of the proposed model is to generate all attributes (e.g. human body, hair, clothes and so on) in an overall attribute space with six feature planes, which are then decomposed and manipulated with different attribute indexes. To precisely extract features of different attributes from the generated feature planes, we propose a novel attribute indexing method as well as an orthogonal projection regularization to enhance the disentanglement. We also introduce a hyper-latent training strategy and an attribute-specific sampling strategy to avoid style entanglement and misleading punishment from the discriminator. Our method allows users to interactively edit selected attributes in the generated 3D human avatars while keeping others fixed. Both qualitative and quantitative experiments demonstrate that our model provides a strong disentanglement between different attributes, allows fine-grained image editing and generates high-quality 3D human avatars.
The SVHN Dataset Is Deceptive for Probabilistic Generative Models Due to a Distribution Mismatch

The Street View House Numbers (SVHN) dataset is a popular benchmark dataset in deep learning. Originally designed for digit classification tasks, the SVHN dataset has been widely used as a benchmark for various other tasks including generative modeling. However, with this work, we aim to warn the community about an issue of the SVHN dataset as a benchmark for generative modeling tasks: we discover that the official split into training set and test set of the SVHN dataset are not drawn from the same distribution. We empirically show that this distribution mismatch has little impact on the classification task (which may explain why this issue has not been detected before), but it severely affects the evaluation of probabilistic generative models, such as Variational Autoencoders and diffusion models. As a workaround, we propose to mix and re-split the official training and test set when SVHN is used for tasks other than classification. We publish a new split and the indices we used to create it at https://jzenn.github. io/svhn-remix/ .
An alternating peak-optimization method for optimal trajectory generation of quadrotor drones

In this paper, we propose an alternating optimization method to address a time-optimal trajectory generation problem. Different from the existing solutions, our approach introduces a new formulation that minimizes the overall trajectory running time while maintaining the polynomial smoothness constraints and incorporating hard limits on motion derivatives to ensure feasibility. To address this problem, an alternating peak-optimization method is developed, which splits the optimization process into two sub-optimizations: the first sub-optimization optimizes polynomial coefficients for smoothness, and the second sub-optimization adjusts the time allocated to each trajectory segment. These are alternated until a feasible minimum-time solution is found. We offer a comprehensive set of simulations and experiments to showcase the superior performance of our approach in comparison to existing methods. A collection of demonstration videos with real drone flying experiments can be accessed at https://www.youtube. com/playlist? list=PLQGtPFK17zUYkwFT-fr0a8E49R8Uq712l .
HumanNeRF-SE: A Simple yet Effective Approach to Animate HumanNeRF with Diverse Poses

We present HumanNeRF-SE, which can synthesize diverse novel pose images with simple input. Previous HumanNeRF studies require large neural networks to fit the human appearance and prior knowledge. Subsequent methods build upon this approach with some improvements. Instead, we reconstruct this approach, combining explicit and implicit human representations with both general and specific mapping processes. Our key insight is that explicit shape can filter the information used to fit implicit representation, and frozen general mapping combined with point-specific mapping can effectively avoid overfitting and improve pose generalization performance. Our explicit and implicit human represent combination architecture is extremely effective. This is reflected in our model's ability to synthesize images under arbitrary poses with few-shot input and increase the speed of synthesizing images by 15 times through a reduction in computational complexity without using any existing acceleration modules. Compared to the state-of-the-art HumanNeRF studies, HumanNeRF-SE achieves better performance with fewer learnable parameters and less training time (see Figure 1).
A complex-projected Rayleigh quotient iteration for targeting interior eigenvalues

We introduce a new Projected Rayleigh Quotient Iteration aimed at improving the convergence behaviour of classic Rayleigh Quotient iteration (RQI) by incorporating approximate information about the target eigenvector at each step. While classic RQI exhibits local cubic convergence for Hermitian matrices, its global behaviour can be unpredictable, whereby it may converge to an eigenvalue far away from the target, even when started with accurate initial conditions. This problem is exacerbated when the eigenvalues are closely spaced. The key idea of the new algorithm is at each step to add a complex-valued projection to the original matrix (that depends on the current eigenvector approximation), such that the unwanted eigenvalues are lifted into the complex plane while the target stays close to the real line, thereby increasing the spacing between the target eigenvalue and the rest of the spectrum. Making better use of the eigenvector approximation leads to more robust convergence behaviour and the new method converges reliably to the correct target eigenpair for a significantly wider range of initial vectors than does classic RQI. We prove that the method converges locally cubically and we present several numerical examples demonstrating the improved global convergence behaviour. In particular, we apply it to compute eigenvalues in a band-gap spectrum of a Sturm-Liouville operator used to model photonic crystal fibres, where the target and unwanted eigenvalues are closely spaced. The examples show that the new method converges to the desired eigenpair even when the eigenvalue spacing is very small, often succeeding when classic RQI fails.
TailorMe: Self-Supervised Learning of an Anatomically Constrained Volumetric Human Shape Model

Human shape spaces have been extensively studied, as they are a core element of human shape and pose inference tasks. Classic methods for creating a human shape model register a surface template mesh to a database of 3D scans and use dimensionality reduction techniques, such as Principal Component Analysis, to learn a compact representation. While these shape models enable global shape modifications by correlating anthropometric measurements with the learned subspace, they only provide limited localized shape control. We instead register a volumetric anatomical template, consisting of skeleton bones and soft tissue, to the surface scans of the CAESAR database. We further enlarge our training data to the full Cartesian product of all skeletons and all soft tissues using physically plausible volumetric deformation transfer. This data is then used to learn an anatomically constrained volumetric human shape model in a self-supervised fashion. The resulting TailorMe model enables shape sampling, localized shape manipulation, and fast inference from given surface scans.
An empirical study of next-basket recommendations

Next Basket Recommender Systems (NBRs) function to recommend the subsequent shopping baskets for users through the modeling of their preferences derived from purchase history, typically manifested as a sequence of historical baskets. Given their widespread applicability in the E-commerce industry, investigations into NBRs have garnered increased attention in recent years. Despite the proliferation of diverse NBR methodologies, a substantial challenge lies in the absence of a systematic and unified evaluation framework across these methodologies. Various studies frequently appraise NBR approaches using disparate datasets and diverse experimental settings, impeding a fair and effective comparative assessment of methodological performance. To bridge this gap, this study undertakes a systematic empirical inquiry into NBRs, reviewing seminal works within the domain and scrutinizing their respective merits and drawbacks. Subsequently, we implement designated NBR algorithms on uniform datasets, employing consistent experimental configurations, and assess their performances via identical metrics. This methodological rigor establishes a cohesive framework for the impartial evaluation of diverse NBR approaches. It is anticipated that this study will furnish a robust foundation and serve as a pivotal reference for forthcoming research endeavors in this dynamic field.
Neural Sign Actors: A diffusion model for 3D sign language production from text

Sign Languages (SL) serve as the predominant mode of communication for the Deaf and Hard of Hearing communities. The advent of deep learning has aided numerous methods in SL recognition and translation, achieving remarkable results. However, Sign Language Production (SLP) poses a challenge for the computer vision community as the motions generated must be realistic and have precise semantic meanings. Most SLP methods rely on 2D data, thus impeding their ability to attain a necessary level of realism. In this work, we propose a diffusion-based SLP model trained on a curated large-scale dataset of 4D signing avatars and their corresponding text transcripts. The proposed method can generate dynamic sequences of 3D avatars from an unconstrained domain of discourse using a diffusion process formed on a novel and anatomically informed graph neural network defined on the SMPL-X body skeleton. Through a series of quantitative and qualitative experiments, we show that the proposed method considerably outperforms previous methods of SLP. We believe that this work presents an important and necessary step towards realistic neural sign avatars, bridging the communication gap between Deaf and hearing communities. The code, method and generated data will be made publicly available.
User Interaction Data in Apps: Comparing Policy Claims to Implementations

As mobile app usage continues to rise, so does the generation of extensive user interaction data, which includes actions such as swiping, zooming, or the time spent on a screen. Apps often collect a large amount of this data and claim to anonymize it, yet concerns arise regarding the adequacy of these measures. In many cases, the so-called anonymized data still has the potential to profile and, in some instances, re-identify individual users. This situation is compounded by a lack of transparency, leading to potential breaches of user trust. Our work investigates the gap between privacy policies and actual app behavior, focusing on the collection and handling of user interaction data. We analyzed the top 100 apps across diverse categories using static analysis methods to evaluate the alignment between policy claims and implemented data collection techniques. Our findings highlight the lack of transparency in data collection and the associated risk of re-identification, raising concerns about user privacy and trust. This study emphasizes the importance of clear communication and enhanced transparency in privacy practices for mobile app development.
Floquet Chiral Quantum Walk in Quantum Computer

Chiral edge states in quantum Hall effect are the paradigmatic example of the quasi-particle with chirality. In even space-time dimensions, the Nielsen-Ninomiya theorem strictly forbids the chiral states in physical isolation. The exceptions to this theorem only occur in the presence of non-locality, non-Hermiticity, or by embedding the system at the boundary of the higher-dimensional bulk. In this work, using the IBM quantum computer platform, we realize the floquet chiral quantum walk enabled by non-locality. The unitary time evolution operator is described by the effective floquet Hamiltonian with infinitely long-ranged coupling. We find that the chiral wave packets lack the common features of the conventional wave phenomena such as Anderson localization. The absence of localization is witnessed by the robustness against the external perturbations. However, the intrinsic quantum errors of the current quantum device give rise to the finite lifetime where the chiral wave packet eventually disperses in the long-time limit. Nevertheless, we observe the stability of the chiral wave by comparing it with the conventional non-chiral model.
Adaptive Instrument Design for Indirect Experiments

Indirect experiments provide a valuable framework for estimating treatment effects in situations where conducting randomized control trials (RCTs) is impractical or unethical. Unlike RCTs, indirect experiments estimate treatment effects by leveraging (conditional) instrumental variables, enabling estimation through encouragement and recommendation rather than strict treatment assignment. However, the sample efficiency of such estimators depends not only on the inherent variability in outcomes but also on the varying compliance levels of users with the instrumental variables and the choice of estimator being used, especially when dealing with numerous instrumental variables. While adaptive experiment design has a rich literature for direct experiments, in this paper we take the initial steps towards enhancing sample efficiency for indirect experiments by adaptively designing a data collection policy over instrumental variables. Our main contribution is a practical computational procedure that utilizes influence functions to search for an optimal data collection policy, minimizing the mean-squared error of the desired (non-linear) estimator. Through experiments conducted in various domains inspired by real-world applications, we showcase how our method can significantly improve the sample efficiency of indirect experiments.
Phytochemical notes on cissampelos spp

Se discuten aspectos fitoquimicos y farmacologicos de Cissampelos ovalifolia D. C. y C. pareira L. y se describen procedimientos de extraccion, aislamiento, purificacion, crornatoqrana (CC, CCF) y espectroscopia (IR, H+ -RMN, SM) de dos alcaloides BBI aislados de esas especies. Se hace una comparacion entre material estudiado proveniente de la Guayana Britanica, la India y varias partes de Colombia.
Channel-Feedback-Free Transmission for Downlink FD-RAN: A Radio Map based Complex-valued Precoding Network Approach

As the demand for high-quality services proliferates, an innovative network architecture, the fully-decoupled RAN (FD-RAN), has emerged for more flexible spectrum resource utilization and lower network costs. However, with the decoupling of uplink base stations and downlink base stations in FD-RAN, the traditional transmission mechanism, which relies on real-time channel feedback, is not suitable as the receiver is not able to feedback accurate and timely channel state information to the transmitter. This paper proposes a novel transmission scheme without relying on physical layer channel feedback. Specifically, we design a radio map based complex-valued precoding network~(RMCPNet) model, which outputs the base station precoding based on user location. RMCPNet comprises multiple subnets, with each subnet responsible for extracting unique modal features from diverse input modalities. Furthermore, the multi-modal embeddings derived from these distinct subnets are integrated within the information fusion layer, culminating in a unified representation. We also develop a specific RMCPNet training algorithm that employs the negative spectral efficiency as the loss function. We evaluate the performance of the proposed scheme on the public DeepMIMO dataset and show that RMCPNet can achieve 16\% and 76\% performance improvements over the conventional real-valued neural network and statistical codebook approach, respectively.
Photometric Metallicity and Distance for the Two RR Lyrae in Segue II and Ursa Major II Dwarf Galaxies Based on Multiband Light Curves

Multiband light curves of two RR Lyrae variables in Segue II and Ursa Major II ultrafaint dwarf galaxies were collected from near simultaneous observations using the Lulin One-meter Telescope in Vgri bands. Together with Gaia G-band light curves, we determined photometric metallicities using empirical relations involving pulsation period and Fourier parameter as dependent parameters. We demonstrated that the RR Lyrae photometric metallicity can be determined accurately when these empirical relations were employed at multiple wavelengths, which can potentially improve the distance determination based on RR Lyrae stars. The photometric metallicities based on our approach were found to be −2.27 ± 0.13 dex and −1.87 ± 0.16 dex for the RR Lyrae in Segue II and Ursa Major II UFD, respectively, with corresponding distance moduli of 17.69 ± 0.15 mag and 17.58 ± 0.15 mag, in agreement with previous literature determinations. This approach of photometric metallicity of RR Lyrae based on multiband optical light curves will be particularly relevant for distance measurements in the era of the Vera C Rubin’s Legacy Survey of Space and Time.
Improved real-space parallelizable matrix-product state compression and its application to unitary quantum dynamics simulation

Towards the efficient simulation of near-term quantum devices using tensor network states, we introduce an improved real-space parallelizable matrix-product state (MPS) compression method. This method enables efficient compression of all virtual bonds in constant time, irrespective of the system size, with controlled accuracy, while it maintains the stability of the wavefunction norm without necessitating sequential renormalization procedures. In addition, we introduce a parallel regauging technique to partially restore the deviated canonical form, thereby improving the accuracy of the simulation in subsequent steps. We further apply this method to simulate unitary quantum dynamics and introduce a parallel time-evolving block-decimation (pTEBD) algorithm. We employ the pTEBD algorithm for extensive simulations of typical one- and two-dimensional quantum circuits, involving over 1000 qubits. The obtained numerical results unequivocally demonstrate that the pTEBD algorithm achieves the same level of simulation precision as the current state-of-the-art MPS algorithm but in polynomially shorter time, exhibiting nearly perfect weak scaling performance on a modern supercomputer.
MedXChat: Bridging CXR Modalities with a Unified Multimodal Large Model

Despite the success of Large Language Models (LLMs) in general image tasks, a gap persists in the medical field for a multimodal large model adept at handling the nuanced diversity of medical images. Addressing this, we propose MedXChat, a unified multimodal large model designed for seamless interactions between medical assistants and users. MedXChat encompasses three key functionalities: CXR(Chest X-ray)-to-Report generation, CXR-based visual question-answering (VQA), and Text-to-CXR synthesis. Our contributions are as follows. Firstly, our model showcases exceptional cross-task adaptability, displaying adeptness across all three defined tasks and outperforming the benchmark models on the MIMIC dataset in medical multimodal applications. Secondly, we introduce an innovative Text-to-CXR synthesis approach that utilizes instruction-following capabilities within the Stable Diffusion (SD) architecture. This technique integrates smoothly with the existing model framework, requiring no extra parameters, thereby maintaining the SD's generative strength while also bestowing upon it the capacity to render fine-grained medical images with high fidelity. Comprehensive experiments validate MedXChat's synergistic enhancement across all tasks. Our instruction data and model will be open-sourced.