Miracle-dz/UniFAR-FTUs huggingface dataset:
Ultimate fracture load of cadaver proximal humeri correlates more strongly with mean combined cortical thickness than with areal cortical index, DEXA density, or canal-to-calcar ratio

Objectives This investigation sought to advance the work published in our prior biomechanical study (Journal of Orthopaedic Research, 2016). We specifically sought to determine whether there are additional easy-to-measure parameters on plain radiographs of the proximal humerus that correlate more strongly with ultimate fracture load, and whether a parameter resembling the Dorr strength/quality characterisation of proximal femurs can be applied to humeri. Materials and Methods A total of 33 adult humeri were used from a previous study where we quantified bone mineral density of the proximal humerus using radiographs and dual-energy x-ray absorptiometry (DEXA), and regional mean cortical thickness and cortical index using radiographs. The bones were fractured in a simulated backwards fall with the humeral head loaded at 2 mm/second via a frustum angled at 30° from the long axis of the bone. Correlations were assessed with ultimate fracture load and these new parameters: cortical index expressed in areas (“areal cortical index”) of larger regions of the diaphysis; the canal-to-calcar ratio used analogous to its application in proximal femurs; and the recently described medial cortical ratio. Results The three new parameters showed the following correlations with ultimate fracture load: areal cortical index (r = 0.56, p < 0.001); canal-to-calcar ratio (r = 0.38, p = 0.03); and medial cortical ratio (r = 0.49, p < 0.005). These correlations were weaker when compared with those that we previously reported: mean cortical thickness of the proximal diaphysis versus ultimate fracture load (r = 0.71; p < 0.001); and mean density in the central humeral head versus ultimate fracture load (r = 0.70; p < 0.001). Conclusion Simple-to-measure radiographic parameters of the proximal humerus reported previously are more useful in predicting ultimate fracture load than are areal cortical index, canal-to-calcar ratio, and medial cortical ratio. Cite this article: J. G. Skedros, C. S. Mears, W. Z. Burkhead. Ultimate fracture load of cadaver proximal humeri correlates more strongly with mean combined cortical thickness than with areal cortical index, DEXA density, or canal-to-calcar ratio. Bone Joint Res 2017;6:1–7. DOI: 10.1302/2046-3758.61. BJR-2016-0145.R1
Sonographic measurements of longitudinal median nerve sliding in patients following nerve repair

Nerve sliding may be restricted following nerve repair. This could result in increased tension across the repair site and lead to poor functional recovery of the nerve. Ultrasound was used to examine longitudinal median nerve sliding in 10 patients who had previously undergone nerve repair surgery following complete division of the median nerve. The median longitudinal movement in the forearm in response to metacarpophalangeal (MCP) joint movements was 2.15 mm on the injured side, compared with 2.54 mm on the uninjured side, a difference that was significant. There was a significant reduction in nerve sliding following repair (median = 8%, range −8% to 54%; P = 0.02), which correlated with time from injury to surgery (rho = 0.87; P = 0.001). These results indicate that ultrasound can be used as an adjunct assessment tool to monitor both morphology and sliding of the nerve through the repair site. It may have future application in the investigation of patients with persisting functional impairment following primary nerve repair. Muscle Nerve, 2009
Structures of Bacterial Flagellar Motors from Two FliF-FliG Gene Fusion Mutants

ABSTRACT Flagella purified from Salmonella enterica serovar Typhimurium contain FliG, FliM, and FliN, cytoplasmic proteins that are important in torque generation and switching, and FliF, a transmembrane structural protein. The motor portion of the flagellum (the basal body complex) has a cytoplasmic C ring and a transmembrane M ring. Incubation of purified basal bodies at pH 4.5 removed FliM and FliN but not FliG or FliF. These basal bodies lacked C rings but had intact M rings, suggesting that FliM and FliN are part of the C ring but not a detectable part of the M ring. Incubation of basal bodies at pH 2.5 removed FliG, FliM, and FliN but not FliF. These basal bodies lacked the C ring, and the cytoplasmic face of the M ring was altered, suggesting that FliG makes up at least part of the cytoplasmic face of the M ring. Further insights into FliG were obtained from cells expressing a fusion protein of FliF and FliG. Flagella from these mutants still rotated but cells were not chemotactic. One mutant is a full-length fusion of FliF and FliG; the second mutant has a deletion lacking the last 56 residues of FliF and the first 94 residues of FliG. In the former, C rings appeared complete, but a portion of the M ring was shifted to higher radius. The C-ring–M-ring interaction appeared to be altered. In basal bodies with the fusion-deletion protein, the C ring was smaller in diameter, and one of its domains occupied space vacated by missing portions of FliF and FliG.
Posttranscriptional control of human gamma interferon gene expression in transfected mouse fibroblasts

Human gamma interferon genomic DNA was introduced into NIH 3T3 fibroblasts by calcium phosphate precipitation and was not expressed in these cells at the cytoplasmic mRNA or protein level. Treatment of the transfected cells with cycloheximide (1 microgram/ml) induced the accumulation of cytoplasmic gamma interferon mRNA and biologically active human gamma interferon. Analysis of the nuclear enriched RNA from untreated cells indicated that human gamma interferon mRNA was present, suggesting that cycloheximide may act by inhibiting a specific nuclease or may enhance the processing or transport of the RNA from the nucleus to the cytoplasm.
Novel technique for volatile optical memory using solitons

Recent advances in optics have shown that solitons have a great potential for upgrading the future optical systems which demand fast and reliable data transfer. Along side different architectures have evolved to realize an optical computer. Due to difference in processing speeds of optical and electronic devices and usage of opto-electronic converters the efficiency of the optical computers is affected. In this paper we bring a novel technique for volatile optical memory using solitons which would be part of realizing an optical computer. Also the principle of read and write operations in the soliton based volatile memory systems is shown
L1 drift and L2 category formation in second language learning

Assimilatory phonetic drift in L1 has been shown to occur in early second language learners when separate L2 categories have not been established. The direction and likelihood of drift is affected by degree of L1:L2 difference [2], and the need to maintain L1 distinctions [10]. We assessed the impact of explicit L2 phonetic training on L1:L2 interaction when novel L2 sounds could lead to a more crowded L1-L2 phonetic space. Native English-speaking college students completed a lesson on Spanish:English stop voicing contrasts midway through their first semester of introductory Spanish. Training led to improved Spanish VOT values, improved L1 and L2 category differentiation for most subjects, and L1 phonetic drift in voiceless and/or voiced stops for individual speakers. Thus, explicit instruction can facilitate L2 category learning even when this produces crowding among L1 and L2 categories. Furthermore, L1 drift is a common but not necessarily inevitable part of the process.
Randomized trial of hypofractionated external-beam radiotherapy for prostate cancer.

PURPOSE To determine if escalated radiation dose using hypofractionation significantly reduces biochemical and/or clinical disease failure (BCDF) in men treated primarily for prostate cancer. PATIENTS AND METHODS Between June 2002 and May 2006, men with favorable- to high-risk prostate cancer were randomly allocated to receive 76 Gy in 38 fractions at 2.0 Gy per fraction (conventional fractionation intensity-modulated radiation therapy [CIMRT]) versus 70.2 Gy in 26 fractions at 2.7 Gy per fraction (hypofractionated IMRT [HIMRT]); the latter was estimated to be equivalent to 84.4 Gy in 2.0 Gy fractions. High-risk patients received long-term androgen deprivation therapy (ADT), and some intermediate-risk patients received short-term ADT. The primary end point was the cumulative incidence of BCDF. Secondarily, toxicity was assessed. RESULTS There were 303 assessable patients with a median follow-up of 68.4 months. No significant differences were seen between the treatment arms in terms of the distribution of patients by clinicopathologic or treatment-related (ADT use and length) factors. The 5-year rates of BCDF were 21.4% (95% CI, 14.8% to 28.7%) for CIMRT and 23.3% (95% CI, 16.4% to 31.0%) for HIMRT (P = .745). There were no statistically significant differences in late toxicity between the arms; however, in subgroup analysis, patients with compromised urinary function before enrollment had significantly worse urinary function after HIMRT. CONCLUSION The hypofractionation regimen did not result in a significant reduction in BCDF; however, it is delivered in 2.5 fewer weeks. Men with compromised urinary function before treatment may not be ideal candidates for this approach.
Foods prepared outside the home: association with selected nutrients and body mass index in adult Australians

Abstract Objective: To determine the proportion of energy from foods prepared outside the home (FPOH) and the relationships with energy and nutrient intakes and body mass index (BMI). Design: A nutrition survey of a representative sample of the Australian population aged 18 years and over (n = 10 863). Measure used was a 24-hour dietary recall. Underreporters (energy intake/estimated basal metabolic rate (EI/BMR) <0.9) were excluded from analysis. Daily energy and selected nutrient intakes were calculated using a 1996 nutrient composition database for all foods/beverages during the 24-hour period. Results: On average FPOH contributed a significant 13% to total energy intake. About a third of the sample had consumed FPOH in the last 24 hours and on average this group consumed a third of their total energy as FPOH. The relative contributions of fat (for men and women) and alcohol (for women) were significantly higher for those in the top tertile of FPOH consumers. The intakes of fibre and selected micronutrients (calcium, iron, zinc, folate and vitamin C) were significantly lower in this group. After adjustment for age and income no relationship between FPOH and BMI was observed. Conclusions: FPOH make a significant contribution to the energy intake of a third of the Australian population. FPOH contribute to poor nutritional intakes. Altering the supply of FPOH may be an effective means of improving diets at a population level.
Vaccination-induced changes in human B-cell repertoire and pneumococcal IgM and IgA antibody at different ages

It is well known that older people are more susceptible to morbidity and mortality from infectious diseases, particularly from pulmonary diseases such as pneumococcal pneumonia where vaccines do not provide efficient protection as in younger populations. We have previously shown that the B‐cell repertoire in the old is reduced and hypothesise that this may contribute to the impaired humoral responses of the elderly. Here, we investigated the repertoire and antibody responses to winter vaccination in two age groups, aged 18–49 and 65–89. We found that the serum IgM and IgA pneumococcal responses were significantly impaired in the older group, with no difference in IgG levels. IGHM spectratype analysis seems to be the most promising in terms of its predictive ability for vaccine responses. Spectratypes showed a clear change in the repertoire at day 7 after vaccination, with a return to the baseline levels at day 28. The changes at day 7 reflected expansion of IGH sequences that have smaller, more hydrophilic, CDR3 regions, and these changes were attenuated in the older group. The older group was more likely to have spectratypes indicative of a reduced diversity at day 0 and day 28. On average, the baseline repertoire in the older group was comprised of larger CDR3 regions than in the younger group. In conclusion, IgA and IgM responses are significantly impaired in the elderly pneumococcal response and are likely key mediators of protection. Hydrophilicity and/or small size of the IGH CDR3 appear to be important in these responses.
MHV Lagrangian for N = 4 super Yang-Mills

Here we formulate two field redefinitions for N = 4 Super Yang-Mills in light cone superspace that generates only MHV vertices in the new Lagrangian. After careful consideration of the S-matrix equivalence theorem, we see that only the canonical transformation gives the MHV Lagrangian that would correspond to the CSW expansion. Being in superspace, it is easier to analyse the equivalence theorem at loop level. We calculate the on shell amplitude for 4pt () MHV in the new lagrangian and show that it reproduces the previously known form. We also briefly discuss the relationship with the off-shell continuation prescription of CSW.
Integrating Multimedia Tools to Enrich Interactions in Live Streaming for Language Learning

Online language lessons have adopted live broadcasted videos to provide more real-time interactive experiences between language teachers and learners. However, learner interactions are primarily limited to the built-in text chat in the live stream. Using text alone, learners cannot get feedback on important aspects of a language, such as speaking skills, that are afforded only by offering richer types of interactions. We present results from a 2-week in-the-wild study, in which we investigate the use of text, audio, video, image, and stickers as interaction tools for language teachers and learners in live streaming. Our language teacher explored three different teaching strategies over four live streamed English lessons, while nine students watched and interacted using multimodal tools. The findings reveal that multimodal communication yields instant feedback and increased engagement, but its use is dependent on factors such as group size, surroundings, time, and online identity.
Ultra-Miniature SIW Cavity Resonators and Filters

This paper presents ultra-miniature substrate integrated waveguide (SIW) cavity resonators, and filters by employing ramp-shaped slots as interdigital capacitors (IDCs) to force the structure to operate in the first negative-order resonance mode. Additionally, a metal patch in the middle metal layer along with disconnected vias is used to increase the equivalent series capacitance of the resonator and accordingly the miniaturization factor. By applying this method to half-mode SIW (HMSIW) and quarter-mode SIW (QMSIW) resonators, 90%, and 95% of miniaturization is achieved, respectively, compared to conventional full-mode SIW resonators. Afterwards, a two-pole bandpass filter is proposed based on the presented QMSIW resonator. Also, by using a combination of HMSIW and QMSIW ultra-miniature resonators, two trisection filters with a controllable transmission zero on either side of the passband are presented. To the best of authors' knowledge, this is the first disclosure of simultaneous use of HMSIW and QMSIW resonators to achieve asymmetric filter response with an ultra-compact size.
Amyloid &bgr;-Induced Nerve Growth Factor Dysmetabolism in Alzheimer Disease

We previously reported that the precursor form of nerve growth factor (pro-NGF) and not mature NGF is liberated in the CNS in an activity-dependent manner, and that its maturation and degradation occur in the extracellular space by the coordinated action of proteases.Here, we present evidence of diminished conversion of pro-NGF to its mature form and of greater NGF degradation in Alzheimer disease (AD) brain samples compared with controls. These alterations of the NGF metabolic pathway likely resulted in the increased pro-NGF levels. The pro-NGF was largely in a peroxynitrited form in the AD samples. Intrahippocampal injection of amyloid-&bgr; oligomers provoked similar upregulation of pro-NGF in naive rats that wasaccompanied by evidence of microglial activation (CD40), increased levels of inducible nitric oxide synthase, and increased activity of the NGF-degrading enzyme matrix metalloproteinase 9. The elevated inducible nitric oxide synthase provoked the generation of biologically inactive, peroxynitrite-modified pro-NGF in amyloid-&bgr; oligomer-injected rats. These parameters were corrected by minocycline treatment. Minocycline also diminished altered matrix metalloproteinase 9, inducible nitric oxide synthase, and microglial activation (CD40); improved cognitive behavior; and normalized pro-NGF levels in a transgenic mouse AD model. The effects of amyloid-&bgr; amyloid CNS burden on NGF metabolism may explain the paradoxical upregulation of pro-NGF in AD accompanied by atrophy of forebrain cholinergic neurons.
Introducing support for scheduled traffic over IEEE audio video bridging networks

The IEEE 802.1 Audio/Video Bridging (AVB) protocol successfully supports audio/video streaming over Ethernet networks and is also a promising candidate for industrial automation. However, several industrial automation applications feature requirements that cannot be fulfilled by the current AVB standard. The next generation of IEEE 802.1 standards, which will specifically target the requirements of automotive and industrial control, is under specification within IEEE 802.1 Working Group. Inspired by such an ongoing work, this paper addresses the introduction in IEEE AVB networks of scheduled traffic, i.e., high priority traffic that is transmitted according to a time schedule so as to ensure no interference from other traffic classes. The paper describes the proposed approach, discusses the design choices and presents a performance assessment based on OMNeT++ simulations.
The Impact of the 2013 Eastern China Smog on Outpatient Visits for Coronary Heart Disease in Shanghai, China

There have been relatively few opportunities to examine the cardiovascular effects of an extreme air pollution event in China. We aimed to examine the impact of the 2013 Eastern China Smog occurring from 2 to 9 December 2013, on outpatient visits for coronary heart diseases (CHD) in a typical hospital in Shanghai, China. We used the over-dispersed, generalized additive model to estimate the relative risk (RR) of the 2013 Eastern China Smog on the outpatient visits by comparing the smog period (2–9 December 2013; 8 days) to the non-smog period (1 November–1 December 2013, and 10 December–28 February 2014; 112 days). This model also controlled for time trends, days of the week, holidays, and meteorological factors. A stratification analysis was performed to estimate sex- and age-specific RRs. The daily average PM2.5 (fine particulate matter with an aerodynamic diameter less than 2.5 μm) concentrations during the smog period were 212 μg/m3, which were three times higher than during the non-smog period (76 μg/m3). The smog in Eastern China in 2013 was significantly associated with an increased risk of outpatient visits for CHD. For example, the RR was 1.18 (95% CI: 1.04, 1.32) on lag 0 day. There were similar effects on males and females. Our analyses provided preliminary evidence that smog constituted a significant risk factor of CHD in China.
Multithreaded Microprocessors : Simultaneous Multithreading vs . Single-Chip Multiprocessing

Single-chip multiprocessing and simultaneous multithreading are two techniques that are able to overcome some of the inherent limitations of superscalar instruction-level parallelism. The goal of either technique is to extend ILP in order to improve single program performance, while at the same time limiting the complexity of the implementation. This paper explores both techniques, and compares and contrasts the advantages as well as the disadvantages of each approach through discussion and illustrative examples.
Testing implementations of transactional memory

Transactional memory is an attractive design concept for scalable multiprocessors because it offers efficient lock-free synchronization and greatly simplifies parallel software. Given the subtle issues involved with concurrency and atomicity, however, it is important that transactional memory systems be carefully designed and aggressively tested to ensure their correctness. In this paper, we propose an axiomatic framework to model the formal specification of a realistic transactional memory system which may contain a mix of transactional and non-transactional operations. Using this framework and extensions to analysis algorithms originally developed for checking traditional memory consistency, we show that the widely practiced pseudo-random testing methodology can be effectively applied to transactional memory systems. Our testing methodology was successful in finding previously unknown bugs in the implementation of TCC, a transactional memory system. We study two flavors of the underlying analysis algorithm, one incomplete and the other complete, and show that the complete algorithm while being theoretically intractable is very efficient in practice.
A Farnesoid X Receptor-Small Heterodimer Partner Regulatory Cascade Modulates Tissue Metalloproteinase Inhibitor-1 and Matrix Metalloprotease Expression in Hepatic Stellate Cells and Promotes Resolution of Liver Fibrosis

The farnesoid X receptor (FXR) is expressed by and regulates hepatic stellate cells (HSCs). In the present study, we investigated whether 6-ethyl chenodeoxycholic acid (6-ECDCA or INT-747), a semisynthetic derivative of chenodeoxycholic acid (CDCA), modulates tissue metalloproteinase inhibitor (TIMP)-1 and matrix metalloprotease (MMP)-2 expression/activity in HSCs and in the liver of rats rendered cirrhotic by 4-week administration of CCl4. Exposure of HSCs to FXR ligands increases small heterodimer partner (SHP) mRNA by 3-fold and reduces basal and thrombin-stimulated expression of α1(I)collagen, α-smooth muscle actin (α-SMA), TIMP-1, and TIMP-2 by ≈60 to 70%, whereas it increased matrix metalloprotease (MMP)-2 activity by 2-fold. In coimmunoprecipitation, electro-mobility shift, and transactivation experiments, FXR activation/overexpression caused a SHP-dependent inhibition of JunD binding to its consensus element in the TIMP-1 promoter. Inhibition of TIMP-1 expression by SHP overexpression enhanced the sensitivity of HSCs to proapoptogenic stimuli. Administration of 3 mg/kg 6-ECDCA, but not 15 mg/kg ursodeoxycholic acid, resulted in early (3–5-day) induction of SHP and prevention of early up-regulation of TIMP-1 mRNA induced by CCl4. In the prevention protocol, 4-week administration of 6-ECDCA reducedα 1(I)collagen, α-SMA, and TIMP-1 mRNA by 60 to 80%, whereas it increased MMP-2 activity by 5-fold. In the resolution protocol, administration of 3 mg/kg 6-ECDCA promoted liver fibrosis resolution and increased the apoptosis of nonparenchyma liver cells. By demonstrating that a FXR-SHP regulatory cascade promotes the development of a quiescent phenotype and increases apoptosis of HSCs, this study establishes that FXR ligands may be beneficial in treatment of liver fibrosis.