Miracle-dz/UniFAR-FTUs huggingface dataset:
MAPPING FROM SPACE – ONTOLOGY BASED MAP PRODUCTION USING SATELLITE IMAGERIES

Determination of the maximum ability for feature extraction from satellite imageries based on ontology procedure using cartographic feature determination is the main objective of this research. Therefore, a special ontology has been developed to extract maximum volume of information available in different high resolution satellite imageries and compare them to the map information layers required in each specific scale due to unified specification for surveying and mapping. ontology seeks to provide an explicit and comprehensive classification of entities in all sphere of being. This study proposes a new method for automatic maximum map feature extraction and reconstruction of high resolution satellite images. For example, in order to extract building blocks to produce 1:5000 scale and smaller maps, the road networks located around the building blocks should be determined. Thus, a new building index has been developed based on concepts obtained from ontology. Building blocks have been extracted with completeness about 83%. Then, road networks have been extracted and reconstructed to create a uniform network with less discontinuity on it. In this case, building blocks have been extracted with proper performance and the false positive value from confusion matrix was reduced by about 7%. Results showed that vegetation cover and water features have been extracted completely (100%) and about 71% of limits have been extracted. Also, the proposed method in this article had the ability to produce a map with largest scale possible from any multi spectral high resolution satellite imagery equal to or smaller than 1:5000. * Corresponding author.
Thyroid carcinoma showing thymus-like elements: a clinicopathologic, immunohistochemical, ultrastructural, and molecular analysis.

OBJECTIVES To investigate the clinicopathologic, immunophenotypic, ultrastructural, and molecular features of thyroid carcinoma showing thymus-like elements (CASTLE). METHODS We retrospectively analyzed the clinicopathologic data of 10 patients with CASTLE and described the immunophenotypic and ultrastructural features of these tumors. The expression of Epstein-Barr virus-encoded RNA and the gene status of EGFR, C-KIT, and HER-2 were also assessed by molecular techniques. RESULTS The tumor cells were positive for CD5, CD117, p63, HMWK, EGFR, GLUT-1, Pax8, E-cadherin, bcl-2, and p53 in all cases and for CA-IX, CEA, p16, HER-2, and neuroendocrine markers in some cases. Ultrastructural examination indicated that the tumor cells contained large quantities of tonofilament with abundant intercellular desmosomes, including intracytoplasmic neuroendocrine granules in one case. EGFR gene amplification in two patients and polyploidy of chromosome 7 in one patient were identified by fluorescence in situ hybridization. Sequencing analysis revealed that a synonymous mutation, Q787Q 2363 (G→A), occurred on exon 20 of the EGFR gene in three patients. CONCLUSIONS GLUT-1 can be used as a novel biomarker for CASTLE, and combined detection of GLUT-1 with CD5 and CD117 aids in the diagnosis of this tumor. Aberrant expression of Bcl-2, p53, p16, E-cadherin, EGFR, C-KIT, and HER-2 may play important roles in the development of CASTLE.
A large scale examination of vehicle recorder data to understand relationship between drivers' behaviors and their past driving histories

We propose an analysis method of driving behaviors based on large-scale and long-term vehicle recorder data to support fleet driver management by classifying drivers by their skill, safety, physical/mental fatigue, aggressiveness, and so on. Previous studies rely on precise data with small number of drivers, which are difficult to extrapolate to general drivers. In this study, we examine ability of a dataset that is sparse but large-scale (over 100 fleet drivers) and long-term (10 months' worth). We focus on classifying drivers recently involved in accidents, and examine correlation with driving behaviors. We propose two models for the classification; entropy-like model and KL divergence model that aim to emphasize the behavioral difference from average drivers. From experiments, we will show some informative findings on behaviors that might cause accidents.
Revision Anterior Cruciate Ligament Reconstruction

Context: Reconstruction of the anterior cruciate ligament (ACL) is one of the most common surgical procedures, with more than 200,000 ACL tears occurring annually. Although primary ACL reconstruction is a successful operation, success rates still range from 75% to 97%. Consequently, several thousand revision ACL reconstructions are performed annually and are unfortunately associated with inferior clinical outcomes when compared with primary reconstructions. Evidence Acquisition: Data were obtained from peer-reviewed literature through a search of the PubMed database (1988-2013) as well as from textbook chapters and surgical technique papers. Study Design: Clinical review. Level of Evidence: Level 4. Results: The clinical outcomes after revision ACL reconstruction are largely based on level IV case series. Much of the existing literature is heterogenous with regard to patient populations, primary and revision surgical techniques, concomitant ligamentous injuries, and additional procedures performed at the time of the revision, which limits generalizability. Nevertheless, there is a general consensus that the outcomes for revision ACL reconstruction are inferior to primary reconstruction. Conclusion: Excellent results can be achieved with regard to graft stability, return to play, and functional knee instability but are generally inferior to primary ACL reconstruction. A staged approach with autograft reconstruction is recommended in any circumstance in which a single-stage approach results in suboptimal graft selection, tunnel position, graft fixation, or biological milieu for tendon-bone healing. Strength-of-Recommendation Taxonomy (SORT): Good results may still be achieved with regard to graft stability, return to play, and functional knee instability, but results are generally inferior to primary ACL reconstruction: Level B.
A Low Dose of Fermented Soy Germ Alleviates Gut Barrier Injury, Hyperalgesia and Faecal Protease Activity in a Rat Model of Inflammatory Bowel Disease

Pro-inflammatory cytokines like macrophage migration inhibitory factor (MIF), IL-1β and TNF-α predominate in inflammatory bowel diseases (IBD) and TNBS colitis. Increased levels of serine proteases activating protease-activated receptor 2 (PAR-2) are found in the lumen and colonic tissue of IBD patients. PAR-2 activity and pro-inflammatory cytokines impair epithelial barrier, facilitating the uptake of luminal aggressors that perpetuate inflammation and visceral pain. Soy extracts contain phytoestrogens (isoflavones) and serine protease inhibitors namely Bowman-Birk Inhibitors (BBI). Since estrogens exhibit anti-inflammatory and epithelial barrier enhancing properties, and that a BBI concentrate improves ulcerative colitis, we aimed to evaluate if a fermented soy germ extract (FSG) with standardized isoflavone profile and stable BBI content exert cumulative or synergistic protection based on protease inhibition and estrogen receptor (ER)-ligand activity in colitic rats. Female rats received orally for 15 d either vehicle or FSG with or without an ER antagonist ICI 182.780 before TNBS intracolonic instillation. Macroscopic and microscopic damages, myeloperoxidase activity, cytokine levels, intestinal paracellular permeability, visceral sensitivity, faecal proteolytic activity and PAR-2 expression were assessed 24 h, 3 d and 5 d post-TNBS. FSG treatment improved the severity of colitis, by decreasing the TNBS-induced rise in gut permeability, visceral sensitivity, faecal proteolytic activity and PAR-2 expression at all post-TNBS points. All FSG effects were reversed by the ICI 182.780 except the decrease in faecal proteolytic activity and PAR-2 expression. In conclusion, the anti-inflammatory properties of FSG treatment result from two distinct but synergic pathways i.e an ER-ligand and a PAR-2 mediated pathway, providing rationale for potential use as adjuvant therapy in IBD.
Targeting the Janus kinases in rheumatoid arthritis: focus on tofacitinib

Introduction: Treatment of rheumatoid arthritis (RA) has markedly advanced by the advent of biologic disease-modifying antirheumatic drugs (DMARDs). However, they require special storage and transportation and remission is observed in ∼ 30%. Tofacitinib inhibits the nonreceptor tyrosine kinase family Janus kinase (JAK), which is activated immediately after cytokines bind to their receptor within the cytoplasmic membrane. Areas covered: Tofacitinib is an orally available tablet and treatment efficacy is similar to biologic DMARDs. Pharmacokinetics, and drug–drug interaction is covered in this article. In addition, efficacy and adverse events from the Phase II and Phase III are overviewed. Additionally, the authors have described the novel mechanism of action (MOA) of tofacitinib in relevance to efficacy and adverse events. Because of its MOA, greater caution is necessary for selecting appropriate patients for treatment initiation and further treatment continuation following clinical trials. Expert opinion: Tofacitinib is a new class of DMARDs orally available with a new mechanism of action and with strong clinical efficacy similar to biologic DMARDs. Multiple cytokines and signaling pathways are partially inhibited at clinical doses that are in contrast to biological DMARDs. Further investigation is necessary to come to a conclusion on risk-benefit ratio and selection of patients.
Sambanden mellan kroppsnöjdhet, självobjektifiering, självkänsla och träningsvanor hos män och kvinnor som tränar på gym

Syftet med denna studie var att ta reda pa om det finns samband mellan gymanvandares kroppsnojdhet, sjalvobjektifiering, sjalvkansla och traningsvanor och om sambanden skiljer sig beroende pa kon.
Supportive care in pediatric oncology

Cure of children with cancer is occurring in ever increasing numbers. Research in supportive care areas such as pain management, emesis control, and infection prevention and treatment, has contributed not only to improved survival, but a better quality of life for children undergoing cancer treatment. Additionally, long-term follow-up of childhood cancer survivors is yielding information that will decrease the morbidity of future treatment regimens.
Combined hyperspectral and 3D characterization of non-healing skin ulcers

Current diagnosis of chronic wounds is based on visual inspection, collection of biopsies and analysis of extracted wound fluid. These methods are expensive, invasive, time consuming and often subjective. In this study a hyperspectral imaging system and a stereo vision system were combined to characterize and classify venous ulcers. It was shown that the combination of 2D imaging spectroscopy and 3D stereo-photogrammetry can provide valuable diagnostic information based on the optical properties of the tissue and the surface geometry of the wound.
A scalable logical topology for optical networks

One of the approaches investigated for multihop lightwave networks is to consider regular graphs as the logical topology for a multihop network. Standard regular topologies are defined only for networks with the number of nodes satisfying some rigid criteria and are not directly usable for multihop networks. Only a few recent proposals (e.g., GEMNET) are regular and yet allow the number of nodes to have any arbitrary value. These networks have one major problem - node addition requires a major redefinition of the network. For example, in a multistar implementation, a large number of retuning of transmitters and receivers and/or renumbering nodes are needed for GEMNET. In this paper we present a new logical topology which has a low diameter but is not strictly regular. The interesting aspect of this topology is that it allows the network to be expanded incrementally involving a relatively small number of edge definitions/redefinitions. In this paper we have described our new topology and its properties. We have also implemented a routing scheme that ensures a low diameter and an algorithm for adding nodes to the network.
Effects of OPA1 mutations on mitochondrial morphology and apoptosis: Relevance to ADOA pathogenesis

To characterize the molecular links between type‐1 autosomal dominant optic atrophy (ADOA) and OPA1 dysfunctions, the effects of pathogenic alleles of this dynamin on mitochondrial morphology and apoptosis were analyzed, either in fibroblasts from affected individuals, or in HeLa cells transfected with similar mutants. The alleles were missense substitutions in the GTPase domain (OPA1G300E and OPA1R290Q) or deletion of the GTPase effector domain (OPA1Δ58). Fragmentation of mitochondria and apoptosis increased in OPA1R290Q fibroblasts and in OPA1G300E transfected HeLa cells. OPA1Δ58 did not influence mitochondrial morphology, but increased the sensitivity to staurosporine of fibroblasts. In these cells, the amount of OPA1 protein was half of that in control fibroblasts. We conclude that GTPase mutants exert a dominant negative effect by competing with wild‐type alleles to integrate into fusion‐competent complexes, whereas C‐terminal truncated alleles act by haplo‐insufficiency. We present a model where antagonistic fusion and fission forces maintain the mitochondrial network, within morphological limits that are compatible with cellular functions. In the retinal ganglion cells (RGCs) of patients suffering from type‐1 ADOA, OPA1‐driven fusion cannot adequately oppose fission, thereby rendering them more sensitive to apoptotic stimuli and eventually leading to optic nerve degeneration. J. Cell. Physiol. 211: 423–430, 2007. © 2006 Wiley‐Liss, Inc.
Microparticle-associated P-selectin reflects platelet activation in preeclampsia

Platelet activation in preeclampsia is reflected by elevated levels of platelets exposing P-selectin. In plasma, a non-cell bound (soluble) form of P-selectin is present. Elevated levels of this soluble form have been reported in preeclampsia. Plasma P-selectin may consist of two fractions: microparticle (MP)--associated P-selectin and non-MP--associated P-selectin. In the present cross-sectional study, we investigated to which extent plasma P-selectin is MP--associated and whether such MP are elevated in preeclamptic patients. Preeclamptic patients (n = 10) were matched with normotensive pregnant women (n = 10) and non-pregnant controls (n = 10). Plasma P-selectin was measured by ELISA. MP were isolated, double labelled with anti-CD61 (GPIIIa) and anti-CD62P (P-selectin) and subsequently analyzed with flowcytometry. Plasma P-selectin concentration was elevated in preeclamptic patients compared to non-pregnant controls (p = 0.007), but not compared to normotensive pregnant women (p = 0.210). Plasma P-selectin is partially MP--associated (3–5%). In pregnancy, the fraction of P-selectin exposing platelet-derived MP (PMP) (10.9%) was increased compared to non-pregnant controls (8%). This fraction further increased in preeclamptic patients (15.4%), and significantly differed from normotensive pregnant women (p = 0.02). A minor fraction of plasma P-selectin is associated with PMP. The fraction of PMP exposing P-selectin is increased in preeclamptic patients and to a lesser extent in normotensive pregnancy. Because MP associated P-selectin exclusively originates from platelets, this fraction indicates platelet activation. Platelet activation is prominent in preeclampsia and this study proves that at least a part of the plasma P-selectin originates from platelets.
A Filipino EFL Teacher’s Positioning in a Thai Secondary School: A Case Study

This study aims to investigate the positioning of “Laura”, a Filipino teacher who teaches English as a foreign language (EFL) in a secondary school in the district of Sai Yok in Kanchanaburi province, Thailand. The concept of positioning helps to understand how individuals take up particular positions as a result of their obligations, acceptance, resistance, or negotiation with regard to other people or groups. Drawing upon a semi-structured interview transcript, the findings suggest that Laura’s positioning is complex, shifting, and multiple as it interplays with a number of factors such as ethnicity,ว linguistic barriers, and sociocultural differences. As a result, she positions Thai students as disrespectful, whereas she positions herself as a stranger in the school. The findings reveal Laura’s negative attitudes towards Thai students’ classroom behaviour. The pedagogical implications of this study are the recognition of Thai students’ culture of learning, concerning classroom behaviour, attitudes, expectations, values and beliefs in a good learning and teaching methodology, which can promote positive positioning for both Laura and her students. It is advisable to examine “non-Thai” EFL teachers from a wider linguistic, ethnic, and cultural background by exploring their attitudes towards school and classroom experiences because they create linguistic, ethnic, and cultural diversity in Thai schools.
Electronic Tool that Helps in Learning How to Play a Flute

— This paper describes the development of an electronic instrument that looks like a flute, which is able to sense the basic musical notes being executed by a specific user. The principal function of the instrument is to teach how to play a flute. This device will generate a significant academic impact, in a field of virtual reality interactive that combine art and technology. With this example is expected to contribute in research and implementation of teaching devices around the world.
3′UTR-located ALU Elements: Donors of Potetial miRNA Target Sites and Mediators of Network miRNA-based Regulatory Interactions

Recent research data reveal complex, network-based interactions between mobile elements and regulatory systems of eukaryotic cells. In this article, we focus on regulatory interactions between Alu elements and micro RNAs (miRNAs). Our results show that the majority of the Alu sequences inserted in 3'UTRs of analyzed human genes carry strong potential target sites for at least 53 different miRNAs. Thus, 3'UTR-located Alu elements may play the role of mobile regulatory modules that supply binding sites for miRNA regulation. Their abundance and ability to distribute a set of certain miRNA target sites may have an important role in establishment, extension, network organization, and, as we suppose – in the regulation and environment-dependent activation/inactivation of some elements of the miRNA regulatory system, as well as for a larger scale RNA-based regulatory interactions. The Alu-miRNA connection may be crucial especially for the primate/human evolution.
Critical decisions and constitutional rules

Many constitutions specify procedures that allow critical decisions to be made with a different rule than routine decisions. We propose a theory of constitutional rules that explains why. The theory is based on the assumption that the type of a decision can be observed, but not verified. We characterize two classes of second-best constitutions, both with clear analogues in real world constitutions: (i) incentive scheme (IS) constitutions that elicit information about the type of a decision through a costly switching procedure and (ii) veto (VT) constitutions that grant limited veto powers to interested parties.
Coding Standard Based Object Oriented Programming Course Teaching Reform

Object Oriented Programming is an important subject for computer major students, this course not only delivers the expertise on how to write program in an OOP language, but also guides students to think in object oriented paradigm. Teachers always found themselves in confusion on which language should be used as the teaching tool. In this paper we present some reform measures took based on our own teaching experiences, by introducing the thinking in object oriented paradigm. We use C#, C++ and Java in parallel to deliver the course. By emphasizing the programming standard in coding, the students acquired the knowledge to distinguish the 3 languages in practice as well as the OOP itself.
trans-dominant interference of type 5 adenovirus E1a mutants in cell transformation

Two type 5 adenovirus (Ad5) early region 1a (E1a) mutants, H5in104 and H5dl105, were impaired in viral replication and cell transformation. In addition, these mutants trans dominantly inhibited the frequency with which H5sub309, a phenotypically wild-type mutant, and H5dl520, a high-frequency transformation mutant, transformed CREF cells. Inhibition of transformation varied in proportion to the input ratio of mutant to coinfecting virus. It was found that H5in104, but not H5dl105, could not complement Ad5 E1b mutants that failed to synthesize 19- or 55-kDa E1b product. H5dl105 yielded 10-fold less virus than the wild-type did in 293 cells, which constitutively express E1a and E1b products; similar low yields were also observed with H5in104 and H5dl105 in another E1a- and E1b-expressing transformed cell line, KB16. Marker rescue and DNA sequence analyses, however, indicated that the phenotypes of H5in104 and H5dl105 were the result of their respective E1a mutations. The data presented are the first to demonstrate that mutants of animal viruses can effect dominant interference with the viral function(s) that produce cell transformation.
A High-Voltage-Tolerant and Precise Charge-Balanced Neuro-Stimulator in Low Voltage CMOS Process

This paper presents a 4 × VDD neuro-stimulator in a 0.18- μm 1.8 V/3.3 V CMOS process. The self-adaption bias technique and stacked MOS configuration are used to prevent transistors from the electrical overstress and gate-oxide reliability issue. A high-voltage-tolerant level shifter with power-on protection is used to drive the neuro-stimulator The reliability measurement of up to 100 million periodic cycles with 3000- μA biphasic stimulations in 12-V power supply has verified that the proposed neuro-stimulator is robust. Precise charge balance is achieved by using a novel current memory cell with the dual calibration loops and leakage current compensation. The charge mismatch is down to 0.25% over all the stimulus current ranges (200-300 μA) The residual average dc current is less than 6.6 nA after shorting operation.
Disturbance Rejection for Biped Humanoids

This paper proposes a simple passivity-based disturbance rejection scheme for force-controllable biped humanoids. The disturbance rejection by force control is useful not only for self-balance, but also for stable and safety physical interaction between human and humanoid robots. The core technique is passivity-based contact force control with gravity-compensation. This makes it easy to control the contact forces in a satisfactory dynamic range without canceling all non-linear terms. The disturbance rejection is located at the higher layer above the contact force controller. It is composed of three sub-controllers; 1) a balancing controller; 2) a stepping controller; and 3) the trigger. Numerical simulations and experiments evaluate the effectiveness of the proposed controller. Although the method is incomplete in the sense that the self-collision between the limbs is ignored, a preliminary experimental result on a real humanoid platform demonstrates that the proposed method can actually make the robot recover the balance under large unknown external perturbations.