Miracle-dz/UniFAR-FTUs huggingface dataset:
Significance of Polypyrimidine Tract–Binding Protein 1 Expression in Colorectal Cancer

Polypyrimidine tract–binding protein (PTBP1) is an RNA-binding protein with various molecular functions related to RNA metabolism and a major repressive regulator of alternative splicing, causing exon skipping in numerous alternatively spliced pre-mRNAs. Here, we have investigated the role of PTBP1 in colorectal cancer. PTBP1 expression levels were significantly overexpressed in cancerous tissues compared with corresponding normal mucosal tissues. We also observed that PTBP1 expression levels, c-MYC expression levels, and PKM2:PKM1 ratio were positively correlated in colorectal cancer specimens. Moreover, PTBP1 expression levels were positively correlated to poor prognosis and lymph node metastasis. In analyses of colorectal cancer cells using siRNA for PTBP1, we observed that PTBP1 affects cell invasion, which was partially correlated to CD44 splicing, and this correlation was also confirmed in clinical samples. PTBP1 expression also affected anchorage-independent growth in colorectal cancer cell lines. PTBP1 expression also affected cell proliferation. Using time-lapse imaging analysis, PTBP1 was implicated in prolonged G2–M phase in HCT116 cells. As for the mechanism of prolonged G2–M phase in HCT116 siPTBP1 cells, Western blotting revealed that PTBP1 expression level was correlated to CDK11p58 expression level, which was reported to play an important role on progression to complete mitosis. These findings indicated that PTBP1 is a potential therapeutic target for colorectal cancer. Mol Cancer Ther; 14(7); 1705–16. ©2015 AACR.
Accompagnement et formes de legitimation des nouvelles entreprises technologiques innovantes

Bien que le champ de recherche relatif a l'accompagnement a la creation d'entreprise ait donne lieu a une abondante litterature dediee aux facteurs de perennite, nous considerons que l'approche institutionnelle des organisations complete ces analyses en termes de comprehension des modalites, des enjeux et des determinants de l'accompagnement. Selon cette approche, un des defis majeurs de l'entreprise nouvelle - generalement pauvre en ressources internes - consiste a trouver une legitimite organisationnelle aupres des acteurs-cles environnementaux, afin de les inciter a lui allouer les moyens qu'elles convoitent. Cette argumentation est confirmee par le cas d'une pepiniere d'entreprises technologiques innovantes du sud de la France, dans la mesure ou celle-ci agit effectivement dans le sens de la legitimation des entreprises qu'elle heberge. Dans ce contexte d'etude, les determinants notables du besoin de legitimite sont relatifs a la dependance de la firme naissante vis-a-vis des detenteurs de ressources externes, a la distance culturelle separant ces deux types de protagonistes et a certaines caracteristiques environnementales. Concernant l'aide, la mission de legitimation qui incombe a l'accompagnateur consiste a favoriser l'insertion des entreprises dans divers reseaux, a faire evoluer l'image du dirigeant selon les criteres socialement acceptes et a tenir un role de mediateur entre des acteurs de cultures divergentes.
Statistical Texture Modeling for Medical Volume Using Generalized N-Dimensional Principal Component Analysis Method and 3D Volume Morphing

In this paper, a statistical texture modeling method is proposed for medical volumes. As the shapes of the human organ are very different from one case to another, 3D volume morphing is applied to normalize all the volume datasets to a same shape for removing shape variations. In order to deal with the problems of high-dimension and small number of medial samples, we propose an effective image compression method named Generalized N-dimensional Principal Component Analysis (GND-PCA) to construct a statistical model. Experiments applied on liver volumes show good performance on generalization using our method. A simple experiment is employed to show that the features extracted by the statistical texture model have capability of discrimination for different types of data, such as normal and abnormal.
Globally Optimal Hand-Eye Calibration Using Branch-and-Bound

This paper introduces a novel solution to the hand-eye calibration problem. It uses camera measurements directly and, at the same time, requires neither prior knowledge of the external camera calibrations nor a known calibration target. Our algorithm uses branch-and-bound approach to minimize an objective function based on the epipolar constraint. Further, it employs Linear Programming to decide the bounding step of the algorithm.Our technique is able to recover both the unknown rotation and translation simultaneously and the solution is guaranteed to be globally optimal with respect to the <inline-formula><tex-math notation="LaTeX">$L_{\infty}$</tex-math><alternatives> <inline-graphic xlink:type="simple" xlink:href="heller-ieq1-2469299.gif"/></alternatives></inline-formula>-norm.
High impact of a start-up journal - surprisingly so?

With the third volume of the International Journal of Internet Science the journal impact factor can now be estimated with increased reliability. For 2008 it will be at 1.64 or higher, based on estimates from citations to the 2006 articles it could turn out as high as 2.83. International Journal of Internet Science's immediacy (2006: 1.17; 2007: 0.71) is unmatched by direct competitors, and even by prestigious journals like the Journal of Personality and Social Psychology (0.40).
Evaluation of static Hand Gesture algorithms

With emergence of the smart and intuitive interfaces during the past few years the need for robust and reliable algorithms rises. Many methods have been proposed for image segmentation, and particularly for static gesture recognition. In this article, using Microsoft Kinect sensor, we attempt to analyze and compare three selected algorithms for image segmentation intended for static gesture recognition, namely Convexity Defects, K-Curvature and Part-based Hand Gesture Recognition.
Role of the rfe gene in the biosynthesis of the Escherichia coli O7-specific lipopolysaccharide and other O-specific polysaccharides containing N-acetylglucosamine

We report that rfe mutants of wild-type strains of Escherichia coli O7, O18, O75, and O111 did not express O-specific polysaccharide unless the rfe mutation was complemented by a cloned rfe gene supplied in a plasmid. The O polysaccharides in these strains are known to have N-acetylglucosamine (GlcNAc) in their O repeats. In addition, in vitro transferase assays with bacterial membranes from either the O7 wild-type strain or its isogenic rfe mutant showed that GlcNAc is the first carbohydrate added onto the lipid acceptor in the assembly of the O7 repeat and that this function is inhibited by tunicamycin. Our results indicate that the rfe gene product is a general requirement for the synthesis of O polysaccharides containing GlcNAc.
Pioglitazone plus a sulphonylurea or metformin is associated with increased lipoprotein particle size in patients with type 2 diabetes

Objective To determine the effect of pioglitazone plus metformin or a sulphonylurea on lipoprotein particle size and subclass distribution in patients with type 2 diabetes. Methods Lipid profiles were determined for blood samples from patients participating in two randomised, double-blind, 24-week studies of pioglitazone 30 mg or 45 mg daily plus either metformin or a sulphonylurea. Results Samples from 177 patients were evaluated; 96 of these patients received a sulphonylurea, and 81 received metformin. Pioglitazone combination treatment produced significant increases from baseline for average and peak low-density lipoprotein (LDL) particle size at weeks 12 and 24 (p<0.0001 for each; range 0.29–0.39 nm for average and 0.36–0.55 nm for peak particle size, respectively). Significant shifts in high-density lipoprotein (HDL) and LDL distribution showed an increase in large particles and a decrease in small particles. For pioglitazone plus metformin, significant increases in levels of apolipoprotein (Apo) AI, Apo AI/AII-containing HDL, and lipoprotein(a) also were noted, whereas Apo B levels decreased. Conclusions These observed changes are thought to affect the atherogenic profile positively. Therefore, pioglitazone combination treatment may lead to decreased cardiovascular risk in patients with type 2 diabetes.
A Smart Management Framework for Multihomed Mobile Nodes & Mobile Routers

The ceaseless evolution of wireless communications is taking the shape of the so called 4G networks: Fundamentally different radio technologies coexist and cooperate to offer continuous connectivity to applications. Mobile devices are now equipped to take advantage of access media abundance to improve the user experience. However, traditional management techniques were quickly obsoleted by the spatial and temporal context variations, especially during mobility. Therefore, novel management frameworks need to be designed to accompany this evolution. The following paper describes SmartMob6 (Smart Management Framework for Multihomed Mobile Nodes & Mobile Routers): a context-aware policy-based management solution combined with a combinatorial optimization algorithm to maximize the satisfaction of the applications while respecting the stakeholders policy rules. Case studies highlight the benefits of such a system over more conventional management techniques.
Picosat Versions 535 1 Restarts and Phases 3 Occurrence Lists

Our SAT solver PicoSAT is an attempt to optimize low-level performance of BooleForce, which shares many of its key features with MiniSAT version 1.14. In this short note we describe the features of PicoSAT version 535, which is the version that was submitted to the SAT 2007 SAT Solver Competition. 1 Restarts and Phases PicoSAT uses an aggressive nested restart scheme, inspired by but simpler than [2], in combination with a more sophisticated strategy for picking the phase of decision variables. The nested restart scheme triggers fast restarts with a high frequency. The period of fast restarts is increased by 10% after every restart until the end of the outer long period with a slow frequency. Then the long period of the outer restart interval is also increased by 10% and the fast restart interval is reset to its initial period of 100 conflicts. In addition, to avoid revisiting the same search space over and over again, the last learned clause before a restart is fixed and never deleted. Other learned clauses are garbage collected in the reduction phase as usual based on their activity [1]. The decision heuristic for the phase is as in RSAT [5]. It simply assigns the decision variable to the same value it was assigned before. Initially, as long a variable has never been assigned, PicoSAT prefers the phase with more occurrences among the original clauses and falls back to assign the variable to false as a tie breaker.
Efeitos de um programa de controle de ansiedade e de visualização mental na melhoria de competências psicológicas em jovens atletas : uma intervenção na natação

This article presents the results and effects of implementing an anxiety control and imagery program with a young athletes’ swimming team, throughout a season. The psychological evaluation done after training the competencies used repeated measures trough a longitudinal plan to observe the frequency and the efficacy of the skills trained. The results suggest that the athletes integrated both the techniques on their mental routines and state the efficacy of those techniques on confronting competitive demands and decreasing anxiety levels during competition. Finally, the importance of mentally training young athletes is discussed, as it promotes their psychological development and their ability to best confront the competitive demands of future upper levels of competition.
ISAM: a Software Architecture for Pervasive Computing

The Mobile Computing is a vision of future that promises to modify the way people work and interact today. It has emerged as a new field, distinct from conventional distributed computing by its focus on mobility and its consequence. The physical and logical mobility allows the creation of applications with news requirements: built-in mobility, adaptability and flexibility. So, software production for this global mobility is complex. Challenges include designing applications which service levels and available resources are unpredictable, and the behavior is variable in time and space. To provide a system architecture that simplifies the task of implementing the mobile applications with adaptive behavior is the objective of the ongoing ISAM Project. In order to achieve its goal, ISAM uses as strategies: (a) integrated environment that provides a programming paradigm and its execution environment; (b) uniform treatment of adaptation through multilevel collaborative model, in which both the system and the application contribute for that. The scheduling process – the core of ISAM architecture, manages this collaboration. Introducing HoloLanguage abstractions that express adaptability makes the control of adaptation by part of application. So, adaptation is not fully transparent to applications. In this paper, we present the main decisions used for designing the ISAM Architecture. We also introduce a first taxonomy for mobile applications with adaptive behavior.
The Effect of Aerobic Exercise on Serum C - Reactive Protein and Leptin Levels in Untrained Middle-Aged Women

Background: Cardiovascular disease is the most common cause of death in the world. The aim of this study was to determine the effect of aerobic exercise on serum inflammatory markers in untrained middle-aged women. Methods: Nineteen healthy female middle-aged were selected by convenience sampling method and were randomly divided into two experimental (n=11) and control (n=8) groups. The exercise protocol included aerobic exercise training lasted for 6 months and 3 sessions per week and every session lasted for 60 minutes and with intensity of 55–65 percent of maximum heart rate reserve (MHR). Blood samples were taken to measure serum leptin and C-Reactive Protein (CRP) before and after aerobic training period. General linear-Repeated measures (GL-RM) was used to comparing of within, Interactive and between means groups. The level of significance was set at P< 0.05. Results: The level of serum leptin in middle-aged women did not change significant. However, the levels of CRP during this period did not change significantly. Conclusion: Six months of aerobic exercise does not induce significant change in serum levels of CRP, while leptin levels reduced in middle-aged women. Regular physical activity probably causes decrease in serum leptin level if body mass index and body fat mass reduce simultaneously.
Deafness in Claudin 11-Null Mice Reveals the Critical Contribution of Basal Cell Tight Junctions to Stria Vascularis Function

Generation of a strong electrical potential in the cochlea is uniquely mammalian and may reflect recent evolutionary advances in cellular voltage-dependent amplifiers. This endocochlear potential is hypothesized to dramatically improve hearing sensitivity, a concept that is difficult to explore experimentally, because manipulating cochlear function frequently causes rapid degenerative changes early in development. Here, we examine the deafness phenotype in adult Claudin 11-null mice, which lack the basal cell tight junctions that give rise to the intrastrial compartment and find little evidence of cochlear pathology. Potassium ion recycling is normal in these mutants, but endocochlear potentials were below 30 mV and hearing thresholds were elevated 50 dB sound pressure level across the frequency spectrum. Together, these data demonstrate the central importance of basal cell tight junctions in the stria vascularis and directly verify the two-cell hypothesis for generation of endocochlear potential. Furthermore, these data indicate that endocochlear potential is an essential component of the power source for the mammalian cochlear amplifier.
Weighted Finite-State Morphological Analysis of Finnish Compounding with HFST-LEXC

Finnish has a very productive compounding and a rich inflectional system, which causes ambiguity in the morphological segmentation of compounds made with finite state transducer methods. In order to disambiguate the compound segmentations, we compare three different strategies, which are all cast in the same probabilistic framework and compared for the first time. We present a method for implementing the probabilistic framework as part of the building process of LexC-style morpheme sub-lexicons creating weighted lexical transducers. To implement the structurally disambiguating morphological analyzer, we use the HFST-LEXC tool which is part of the open source Helsinki Finite-State Technology. Using our Finnish test corpus with 53 270 compounds, we demonstrate that it is possible to use non-compound token probabilities to disambiguate the compounding structure. Non-compound token probabilities are easy to obtain from raw data compared with obtaining the probabilities of prefixes of segmented and disambiguated compounds.
Analysis of the antibody repertoire of astrocytoma patients against antigens expressed by gliomas

The molecular characterization of antigens preferentially or exclusively expressed by astrocytomas and recognized by the autologous immune system are a prerequisite for the development of specific vaccines. To identify such antigens, we screened 5 cDNA expression libraries derived from astrocytomas and other gliomas for reactivity with high‐titered IgG antibodies in the sera of astrocytoma patients using SEREX, the serologic identification of antigens by recombinant cDNA expression cloning. Autologous and allogeneic SEREX analysis of >5 × 106 clones with the sera of 18 astrocytoma patients revealed 10 antigens: the differentiation antigen glial fibrillary acidic protein (GFAP), Bax‐inhibitor 1 (which was overexpressed in all glioma samples tested), 3 other molecules involved in the regulation of gene expression and proliferation (the nm23‐H2‐encoded nucleoside diphosphate kinase B, the Ran binding protein‐2 and a DNA binding protein encoded by the son gene), SP40,40 (a complement inhibitory molecule), the chaperonin TCP‐1, calnexin and 2 new gene products. No immune responses were detected against the “shared tumor” or “cancer testis antigens” that are regularly expressed in gliomas. Antibody responses in astrocytoma patients against antigens expressed by gliomas were rare and, with the exception of Bax‐inhibitor 1 and the product of the son gene, were also found in apparently healthy controls. We conclude that although astrocytomas express a broad spectrum of antigens, they elicit antibody responses only rarely, most likely because of their intrinsic immunosuppressive effects. © 2001 Wiley‐Liss, Inc.
Depression-Burnout Overlap in Physicians

Background Whether burnout is a distinct phenomenon rather than a type of depression and whether it is a syndrome, limited to three “core” components (emotional exhaustion, depersonalization and low personal accomplishment) are subjects of current debate. We investigated the depression-burnout overlap, and the pertinence of these three components in a large, representative sample of physicians. Methods In a cross-sectional study, all Austrian physicians were invited to answer a questionnaire that included the Major Depression Inventory (MDI), the Hamburg Burnout Inventory (HBI), as well as demographic and job-related parameters. Of the 40093 physicians who received an invitation, a total of 6351 (15.8%) participated. The data of 5897 participants were suitable for analysis. Results Of the participants, 10.3% were affected by major depression. Our study results suggest that potentially 50.7% of the participants were affected by symptoms of burnout. Compared to physicians unaffected by burnout, the odds ratio of suffering from major depression was 2.99 (95% CI 2.21–4.06) for physicians with mild, 10.14 (95% CI 7.58–13.59) for physicians with moderate, 46.84 (95% CI 35.25–62.24) for physicians with severe burnout and 92.78 (95% CI 62.96–136.74) for the 3% of participants with the highest HBI_sum (sum score of all ten HBI components). The HBI components Emotional Exhaustion, Personal Accomplishment and Detachment (representing depersonalization) tend to correlate more highly with the main symptoms of major depression (sadness, lack of interest and lack of energy) than with each other. A combination of the HBI components Emotional Exhaustion, Helplessness, Inner Void and Tedium (adj.R2 = 0.92) explained more HBI_sum variance than the three “core” components (adj.R2 = 0.85) of burnout combined. Cronbach’s alpha for Emotional Exhaustion, Helplessness, Inner Void and Tedium combined was 0.90 compared to α = 0.54 for the combination of the three “core” components. Conclusions This study demonstrates the overlap of burnout and major depression in terms of symptoms and the deficiency of the three-dimensional concept of burnout. In our opinion, it might be preferable to use multidimensional burnout inventories in combination with valid depression scales than to rely exclusively on MBI when clinically assessing burnout.
LIMSI’s Statistical Translation Systems for WMT’10

This paper describes our Statistical Machine Translation systems for the WMT10 evaluation, where LIMSI participated for two language pairs (French-English and German-English, in both directions). For German-English, we concentrated on normalizing the German side through a proper preprocessing, aimed at reducing the lexical redundancy and at splitting complex compounds. For French-English, we studied two extensions of our in-house N-code decoder: firstly, the effect of integrating a new bilingual reordering model; second, the use of adaptation techniques for the translation model. For both set of experiments, we report the improvements obtained on the development and test data.
Novel Square-Wave Signal Injection Method Using Zero-Sequence Voltage for Sensorless Control of PMSM Drives

In this paper, a novel square-wave-type carrier signal injection method using zero-sequence voltage is proposed for sensorless control of permanent-magnet (PM) synchronous machine drives. Different from the conventional square-wave-type injection methods employed in the stationary reference frame and estimated synchronous reference frame, the proposed square-wave injection is performed on the estimated reference frame, which rotates anticlockwise at twice estimated rotor electrical angular speed. Compared to the conventional square-wave methods with carrier current sensing, the proposed strategy using zero-sequence voltage has two main advantages, 1) the amplitude of the resultant carrier response is not related to the injection frequency, and 2) the carrier response does not require differentiation calculation for rotor position estimation. Therefore, the proposed method is more robust and also much simpler for signal demodulation, which can combine the synergies of zero-sequence method and square-wave injection (i.e., increased accuracy, bandwidths, and stability, etc.). Finally, all the theoretical analyses are validated by experiments on a laboratory PM machine.