Miracle-dz/UniFAR-FTUs huggingface dataset:
A Comprehensive Guide to Patient‐Focused Management Strategies for Crohn Disease

In Crohn disease, a vigorous inflammatory cascade is caused by the overactivation of helper T-cells in the gastrointestinal system. The results of this inflammation manifest themselves as the symptoms of Crohn disease. This article describes the pathophysiology of Crohn disease as well as multiple pharmacologic and nonpharmacologic interventions that may assist patients with Crohn disease in preventing exacerbations and maintaining longer remissions.
A Reconfigurable Built-In Self-Repair Scheme for Multiple Repairable RAMs in SOCs

This paper presents a reconfigurable built-in self-repair (ReBISR) scheme for multiple repairable RAM cores with different sizes and redundancy organizations (i.e., spare rows/spare columns or spare rows/spare IOs). We also propose an efficient built-in redundancy-analysis (BIRA) algorithm for allocating redundancies for the ReBISR scheme. A reconfigurable BIRA (ReBIRA) circuit is realized to perform the proposed BIRA algorithm for the ReBISR scheme. Experimental results show that the ReBISR scheme can achieve high repair rate (i.e., the ratio of the number of repaired memories to the number of defective memories). The area cost of the reconfigurable BIRA is very small, e.g., the area cost is only about 1.5% if 512times4times256 design parameters and four memory instances (64times2times32, 128times2times64, 256times4times128, and 512times4times256) are considered. Also, the ratio of the redundancy analysis time to the test time is very small, e.g., the ratio for a 512times4times256-bit memory tested by a March-14N algorithm with solid data backgrounds is only about 0.25%
Genomics Transcriptomes and shRNA Suppressors in a TP 53 Allele – Speci fi c Model of Early-Onset Colon Cancer in African Americans

African Americans are disproportionately affected by early-onset, high-grade malignancies. A fraction of this cancer health disparity can be explained by genetic differences between individuals of African or European descent. Here the wild-type Pro/Pro genotype at the TP53Pro72Arg (P72R) polymorphism (SNP: rs1042522) is more frequent in African Americans with cancer than in African Americans without cancer (51% vs. 37%), and is associatedwith a significant increase in the rates of cancer diagnosis inAfricanAmericans. To test the hypothesis that Tp53 allele–specific gene expression may contribute to African American cancer disparities, TP53 hemizygous knockout variants were generated and characterized in the RKO colon carcinoma cell line, which is wild type for TP53 and heterozygous at the TP53Pro72Arg locus. Transcriptome profiling, using RNAseq, in response to the DNA-damaging agent etoposide revealed a large number of Tp53-regulated transcripts, but also a subset of transcripts that wereTP53Pro72Arg allele specific. In addition, a shRNA-library suppressor screen for Tp53 allele– specific escape from Tp53-induced arrest was performed. Several novel RNAi suppressors of Tp53 were identified, one ofwhich,PRDM1b (BLIMP-1), was confirmed to be anArg-specific transcript. Prdm1b silences target genes by recruiting H3K9 trimethyl (H3K9me3) repressive chromatin marks, and is necessary for stem cell differentiation. These results reveal a novel model for African American cancer disparity, in which the TP53 codon 72 allele influences lifetime cancer risk by driving damaged cells to differentiation through an epigenetic mechanism involving gene silencing. Implications: TP53 P72R polymorphism significantly contributes to increased African American cancer disparity. Mol Cancer Res; 12(7); 1029–41. 2014 AACR.
Does security matter in tourism demand?

This paper aims to investigate the relationship between security and international tourist arrivals. The system Generalized Method of Moments technique is applied in two panels of 29 developed and 45 developing countries over the period 2006–2012. Employing social, economic and political security indexes beside other control variables, the results show that the relationship among all the three sub-indexes of security and tourism is positive and significant in developed nations while it is negative and significant in developing countries.
A Pilot Study of the Effect of Aloe barbadensis Mill. Extract (AVH200®) in Patients with Irritable Bowel Syndrome: a Randomized, Double-Blind, Placebo-Controlled Study.

BACKGROUND AND AIMS Few effective treatment options exist for patients with irritable bowel syndrome (IBS), and many patients state the use of aloe vera products reduce their symptoms. The aim of this pilot study was to investigate the effect of Aloe barbadensis Mill. Extract (AVH200®) in adult patients with IBS in a randomized, double-blind, placebo controlled study. METHODS Sixty-eight adult patients diagnosed with IBS according to the Rome III criteria were randomized to receive AVH200® or matching placebo for four weeks. Symptom questionnaires were completed on a weekly basis and the patients were asked if they had had adequate relief of their gastrointestinal symptoms. RESULTS A tendency towards a higher proportion of responders in the aloe vera group (55%) vs. placebo (31%), (p=0.09) was observed, and the proportion of subjects who reported adequate relief at least 50% of the weeks during the treatment period tended to be larger in the aloe vera vs. placebo group (33% vs. 14%; p=0.12). The overall severity of the gastrointestinal symptoms was reduced in the aloe vera group (314+/-83 vs. 257+/-107; p=0.003) but not the placebo group (276+/-88 vs. 253+/-100; NS), without difference between the groups (p=0.10). AVH200® was well tolerated and no serious adverse events were observed. CONCLUSION Even though the primary endpoint was not met, AVH200® seems to be a promising treatment option for patients with IBS owing to the positive results seen within the secondary endpoints. This study may have been underpowered to detect a clinically meaningful difference between the treatment groups, and therefore larger randomized, controlled studies are required to confirm these results and to elucidate potential mechanisms explaining its effect.
Interleukin-1 beta stimulates nitrite production in the rat ovary: evidence for heterologous cell-cell interaction and for insulin-mediated regulation of the inducible isoform of nitric oxide synthase.

Recent studies suggest that endogenously generated nitric oxide (NO) may mediate the effects of cytokines in a variety of tissues. In an effort to determine whether NO generation mediates any of the intraovarian actions of interleukin-1 beta (IL-1 beta), we have looked for and characterized the accumulation of nitrite by IL-1 beta-treated, cultured whole ovarian dispersates. Application of IL-1 beta significantly enhanced basal nitrite release in a dose-, cell density- and time-dependent manner, the latter characterized by a lag time of about 20 h, suggestive of induction of NO synthase (NOS). Cellular NOS activity was also elevated by IL-1 beta. Sustained nitrite accumulation required continuous application of IL-1 beta. The maximally stimulating dose of IL-1 beta (50 ng/ml) produced a 10-fold increase in nitrite accumulation by 96 h of culture, an effect reduced 23% when cells were cultured in substrate (i.e., arginine)-free media. IL-1 beta-stimulated nitrite accumulation was reduced to control levels by the simultaneous application of an IL-1 beta receptor antagonist, thereby suggesting a specific receptor-mediated effect. Both the control and IL-1 beta-stimulated levels of nitrite accumulation were attenuated in a dose-dependent manner by inhibitors that favor the inducible form of NOS. In contrast, selective inhibitors of the constitutive form of NOS were significantly less potent. No inhibition was noted after application of an inactive stereoisomeric analogue. IL-1 beta-induced nitrite accumulation was shown to require cell-cell interaction between granulosa and theca-interstitial cells. (ABSTRACT TRUNCATED AT 250 WORDS)
Coherence optimization using the polarization state conformation in PolInSAR

A new coherence optimization algorithm is proposed for polarimetric synthetic aperture radar (SAR) interferometry applications by using the polarization state conformation algorithm based on the polarimetric basis transformation along with the polarization signatures. Through application of this algorithm, the resemblance between the scattering mechanisms of the same target in the repeat-pass polarimetric SAR (POLSAR) images is maximized. Then, coherence maps between the repeat-pass POLSAR images, before and after application of the algorithm, are generated. The coherences obtained by this method represent the best coherences or optimized coherences between the POLSAR images. The effects predicted by the theory are confirmed by the POLSAR data acquired by the Jet Propulsion Laboratory Spaceborne Imaging Radar mission.
Induction of apoptosis in MCF-7:WS8 breast cancer cells by beta-lapachone.

Beta-lapachone (beta-lap) affects a number of enzymes in vitro, including type I topoisomerase (Topo I); however, its exact intracellular target(s) and mechanism of cell killing remain unknown. We compared the cytotoxic responses of MCF-7:WS8 (MCF-7) human breast cancer cells after 4-h pulses of beta-lap or camptothecin (CPT), a known Topo I poison. A direct correlation between loss of survival and apoptosis was seen after beta-lap treatment (LD50 = 2.5 microM). A concentration-dependent, transient sub-2 N preapoptotic cell population was observed at 4-8 h. Estrogen deprivation-induced synchronization and bromodeoxyuridine-labeling studies revealed an apoptotic exit point near the G1-S border. Apoptosis activated by beta-lap was closely correlated with cleavage of lamin B but not with increases in p53/p21 or decreases in bcl-2. Loss of hyperphosphorylated forms of the retinoblastoma protein was observed within 5 h, but cyclins A, B1, and E levels were unaltered for up to 72 h after 5 microM beta-lap. Topo I and Topo IIalpha levels decreased at > 24 h. Logarithmic-phase MCF-7 cells were not affected by < or = 1 microM beta-lap. In contrast, dramatic and irreversible G2-M arrest with no apoptosis was observed in MCF-7 cells treated with 1 microM CPT, monitored for 6-10 days posttreatment. MCF-7 cells treated with supralethal doses of CPT (5 microM) resulted in only approximately 20% apoptosis. No correlation between apoptosis and loss of survival was observed. MCF-7 cells exposed to > 5 microM CPT arrested at key cell cycle checkpoints (i.e., G1, S, and G2-M), with little or no movement for 6 days. Ten-fold increases in p53/p21 and 2-5-fold decreases in bcl-2, Topo I, Topo IIalpha, and cyclins A and B1, with no change in cyclin E, were observed. Temporal decreases in bcl-2 and cleavage of lamin B corresponded to the minimal apoptotic response observed. Beta-lap activated apoptosis without inducing p53/p21 or cell cycle arrest responses and killed MCF-7 cells solely by apoptosis. In contrast, concentration-dependent increases in nuclear p53/p21 and various cell cycle checkpoint arrests were seen in MCF-7 cells after CPT. Despite dramatic p53/p21 protein induction responses, CPT-treated MCF-7 cells showed low levels of apoptosis, possibly due to protective cell cycle checkpoints or the lack of specific CPT-activated apoptotic pathways in MCF-7 cells.
Multi-domain Text-to-Speech Synthesis b

This paper describes a multi-domain text-to-speech (MD-TTS) synthesis strategy for generating speech among different domains and so increasing the flexibility of high quality TTS systems. To that effect, the MD-TTS introduces a flexible TTS architecture that includes an automatic domain classification module, which allows MD-TTS systems to be implemented by different synthesis strategies and speech corpus typologies. In this work, the performance of a corpus-based MD-TTS system is subjectively validated by means of several perceptual tests.
Vertical distribution of major sulfate-reducing bacteria in a eutrophic shallow meromictic lake

Title Vertical distribution of major sulfate-reducing bacteria in a shallow eutrophic meromictic lake Author(s) Kubo, Kyoko; Kojima, Hisaya; Fukui, Manabu Citation Systematic and Applied Microbiology, 37(7): 510-519 Issue Date 2014-10 Doc URL http://hdl.handle. net/2115/57661 Type article (author version) Additional Information There are other files related to this item in HUSCAP. Check the above URL. File Information suppl.pdf (Supplementary material)
On the Desirability of Supply-Side Intervention in a Monetary Union

This paper examines the desirability of supply-side intervention within a monetary union, given the constraints on monetary and fiscal policy, and compares it with an economic framework characterized by the independence of monetary policy. To this end, we first develop a simple two-country model in order to analyse in strategic terms how the authorities can deal with monetary, real and supply shocks, and the extent to which supply-side intervention may be useful to deal with these shocks. Next, we study whether the formation of a monetary union could be beneficial when there is coordination over labour market intervention.
Survival of Enterococcus faecalis in infected dentinal tubules after root canal filling with different root canal sealers in vitro.

AIM To investigate the ability of different endodontic sealers and calcium hydroxide to kill bacteria in experimentally infected dentinal tubules. METHODOLOGY Fifty-six human root segments were enlarged to size 2 (ISO size 090) Largo Peeso Reamer. After treatment with 17% EDTA and 5% NaOCl for 4 min each, the specimens were infected with Enterococcus faecalis for 3 weeks. The roots were divided into eight groups and filled with gutta-percha and AH Plus (AH); Grossman's sealer (GS); Ketac-Endo (KE); Apexit (AP); RoekoSeal Automix (RSA); or RoekoSeal Automix with an experimental primer (RP), or calcium hydroxide (CH) only. One group of specimens was left unfilled for control (CT). Following storage in humid conditions at 37 degrees C for 7 days, the root canals were re-established with new sterile Largo size 2. Dentine samples from each canal were then collected using a sterile size 5 (ISO size 150) Largo Peeso Reamer. The number of colony-forming units (CFU) was determined for each sample. RESULTS The mean log10 CFU in all test groups was significantly lower (P < 0.05) than that in the CT group. Root filling with AH and GS killed bacteria (mean CFU = 0) in the dentinal tubules. The mean log10 CFU for the CH group (0.53) was lower than that of RSA, AP, RP and KE (1.36, 1.40, 1.46 and 1.94, respectively), but only the difference between the CH and the KE groups was statistically significant (P < 0.05). CONCLUSION Root fillings in vitro with gutta-percha and AH or GS were effective in killing E. faecalis in dentinal tubules. Other endodontic sealers, as well as CH, were less effective.
SPR‐based plastic optical fibre biosensor for the detection of C‐reactive protein in serum

A plastic optical fibre biosensor based on surface plasmon resonance for the detection of C‐reactive protein (CRP) in serum is proposed. The biosensor was integrated into a home‐made thermo‐stabilized microfluidic system that allows avoiding any thermal and/or mechanical fluctuation and maintaining the best stable conditions during the measurements. A working range of 0.006–70 mg L–1 and a limit of detection of 0.009 mg L–1 were achieved. These results are among the best compared to other SPR‐based biosensors for CRP detection, especially considering that they were achieved in a real and complex medium, i.e. serum. In addition, since the sensor performances satisfy those requested in physiologically‐relevant clinical applications, the whole biosensing platform could well address high sensitive, easy to realize, real‐time, label‐free, portable and low cost diagnosis of CRP for future lab‐on‐a‐chip applications. 3D sketch (left) of the thermo‐stabilized home‐made flow cell developed to house the SPR‐based plastic optical fibre biosensor. Exemplary response curve (shift of the SPR wavelength versus time) of the proposed biosensor (right) for the detection of C‐reactive protein in serum.
Writing up the region: anchor firm dismantling and the construction of a perceived regional advantage in Swedish news media

ABSTRACT This study investigates how geographic representations and regional industrial identity in news media are used to mobilize local/regional actors and to attract inward and outward investments by mediating and narrating stories of the recovery and rebirth of a region in distress – that is, how media contribute to economic development in or of the region. The study targets media attention covering the dismantling and relocation of two regionally embedded life science and likewise anchor firms: the Pharmacia and Upjohn merger in Uppsala in 1995 and the closure of AstraZeneca's operations in Lund in 2010. By drawing on the method of framing and content analysis of news articles derived from a public media database, the analysis show that: (a) geographic representation and associations are intensified in times of media turbulence; (b) news coverage follows two subsequent phases (an initial ‘crisis’ phase and a following more optimistic ‘recovery’ phase) and (c) news media (as intermediary actors and arenas) by communicating ideas of a shared regional industrial identity contribute to the construction of a ‘perceived regional advantage’ (as understood and communicated by news media). Thus, regional industrial identity-building and how the region is perceived by internal and external audiences are important for regional development.
Evidence for Resident Memory T cells in Rasmussen Encephalitis

Investigators from University of California Los Angeles studied the presence of different T cell subset population in the brain tissue of 7 patients with Rasmussen encephalitis, a rare neuroinflammatory disorder characterized by intractable seizures and usually associated with progressive hemi cerebral atrophy, who underwent brain surgery and compared them to patients with focal cortical dysplasia.
Women and Men - a New Conversation about Equality

The author believes that, although Australian women have made great progress, there is need for a new community discussion on building a stronger partnership between men and women. She discusses problems that continue to obstruct efforts to foster gender equality. She also summarises the Australian government's vision for contemporary women's policy for the 21st century. On Thursday 6 November, Tanya Pliberseck addressed The Sydney Institute to discuss persisting obstacles to gender equality and to share the government's vision for contemporary women's policy for the twenty-first century.
A perspective on rational drug design with cyclopentenone: targeting the proteome with the cyclopentenone chemical moiety

The biological activity of cyclopentenone prostaglandins, of members of clavulones, and of other natural and synthetic compounds is strongly related to the presence of a conjugate cylcopentenone (CP) chemical moiety in their structure. CP reactivity is specifically directed toward the proteome, to covalent binding of crucial sulphydril groups on targeted proteins. In the literature it has been shown that directing this special CP biochemical reactivity by means of additional orienting constituents is a feasible strategy for inactivating specific enzymes in a cell. The introduction of a CP moiety into anticancer molecules, such as jasmonates and chalcones, has been shown to greatly boost their activity, probably due to the stable covalent chemical interaction with their targets. In general, similar strategies could lead to the development of a novel repertoire of therapeutic molecules targeted against specific pathogenetic anomalies of the proteome of diseased cells.
Globalization and stakeholder conflicts: a corporate perspective

There is considerable confusion and hyperbole about globalization. Disagreements range over whether it is a process or an end-state, over the degree to which it is happening or has already reached, and over its implications for the power and ultimate survival of the state. By examining the micro-foundations of globalization, the pressures that firms feel from their more diverse stakeholders, this article attempts to rectfy and to look beyond the simplistic, often implicit, assumption that firms gain, while states lose,from globalization. Both firms and governments face heightened risks and both need new skills to deal with them. *
The effect of the host immune response on the parasitic nematode Strongyloides ratti

The host immune response has profound effects on parasitic nematode infections. Here we have investigated how a range of infection parameters are affected by host immune responses and by their suppression and enhancement. The infection parameters considered were the number of parasitic females, their size, per capita fecundity and intestinal position. We found that in immunosuppressive treatments worms persist in the gut, sometimes with a greater per capita fecundity, maintain their size and have a more anterior gut position, compared with worms from control animals. In immunization treatments there are fewer worms in the gut, sometimes with a lower per capita fecundity and they are shorter and have a more posterior gut position, compared with worms from control animals. Worms from animals immunosuppressed by corticosteroid treatment reverse their changes in size and gut position. This description of these phenomena pave the way for a molecular biological analysis of how these changes in infection parameters are brought about by the host immune response.
Therapists' and clients' significant experiences underlying psychotherapy discourse

Abstract This article complements the narrative research that focuses on the process and content of what is said in psychotherapy by examining clients' and therapists' significant experiences beneath the in-session discourse. Toward this end, the authors recorded one midtherapy session from each of four dyads, and the therapist and client from each dyad were then interviewed using an interpersonal process recall method. Participants were asked what they experienced as significant during the session and to describe their rationale for that selection. Descriptions of these experiences were organized into categories using an inductive method. An analysis of therapist- and client-originated categories was conducted to elucidate the often unspoken concerns of participants. The range of internal experiences that underlie narration in psychotherapy is explicated.
Rules Versus Flexibility: Does the Stability Pact Limit Budgetary Stabilisers?

Bertholt Leeftink investigates whether a potential trade-off exists between budgetary sustainability and budgetary stabilisation and whether monetary union requires closer budgetary co-ordination than currently envisaged. Leeftink argues that the Stability Pact far from limiting member countries' capability to cushion asymmetric shocks, may even facilitate stabilisation. The reason being that the prudent budgetary policy induced by the Pact reduces uncertainty about the sustainability of fiscal policy and therefore restores the stabilising properties of the budget: by enhancing credibility, sustainability allows effective stabilisation policy. Leeftink also compares the intertemporal stabilisation provided by the national budgets of EU member countries with that offered by the federal budget in the USA and finds that the two systems offer a similar degree of stabilisation.