Miracle-dz/UniFAR-FTUs huggingface dataset:
Light microscopic autoradiographic localization of mu and delta opioid binding sites in the mouse central nervous system

Much work has been done on opioid systems in the rat CNS. Although the mouse is widely used in pharmacological studies of opioid action, little has been done to characterize opioid systems in this species. In the present study the distribution of mu and delta opioid binding sites in the mouse CNS was examined using a quantitative in vitro autoradiography procedure. Tritiated dihydromorphine was used to visualize mu sites and [3H-d-Ala2-d-Leu5]enkephalin with a low concentration of morphine was used to visualize delta sites. Mu and delta site localizations in the mouse are very similar to those previously described in the rat ( Goodman , R.R., S.H. Snyder, M.J. Kuhar , and W.S. Young, 3d (1980) Proc. Natl. Acad. Sci. U.S.A. 77:6239– 6243), with certain exceptions and additions. Mu and delta sites were observed in sensory processing areas, limbic system, extrapyramidal motor system, and cranial parasympathetic system. Differential distributions of mu and delta sites were noted in many areas. Mu sites were prominent in laminae I, IV, and VI of the neocortex, in patches in the striatum, and in the ventral pallidum, nucleus accumbens, medial and midline thalamic nuclei, medial habenular nucleus, interpeduncular nucleus, and laminae I and II of the spinal cord. In contrast, delta sites were prominent in all laminae of the neocortex, olfactory tubercle, diffusely throughout the striatum, and in the basal, lateral, and cortical nuclei of the amygdala. The determination of the differential distributions of opioid binding sites should prove useful in suggesting anatomical substrates for the actions of opiates and opioids.
"Everyone Brings Their Grain of Salt": Designing for Low-Literate Parental Engagement with a Mobile Literacy Technology in Côte d'Ivoire

Significant research has demonstrated the crucial role that parents play in supporting the development of children's literacy, but in contexts where adults may lack sufficient literacy in the target language, it is not clear how to most effectively scaffold parental support for children's literacy. Prior work has designed technologies to teach children literacy directly, but this work has not focused on designing for low-literate parents, particularly for multilingual and developing contexts. In this paper, we describe findings from a qualitative study conducted in several regions of rural Côte d'Ivoire to understand Ivorian parents' beliefs, desires, and preferences for French literacy. We discuss themes that emerged from these interviews, surrounding ideas of trust, collaboration, and culturally-responsive design, and we highlight implications for the design of technology to scaffold low-literate parental support for children's literacy.
Gabber: Supporting Voice in Participatory Qualitative Practices

We describe the iterative design, development and learning process we undertook to produce Gabber, a digital platform that aims to support distributed capture of spoken interviews and discussions, and their qualitative analysis. Our aim is to reduce both expertise and cost barriers associated with existing technologies, making the process more inclusive. Gabber structures distributed audio data capture, facilitates participatory sensemaking, and supports collaborative reuse of audio. We describe our design and development journey across three distinct field trials over a two-year period. Reflecting on the iterative design process, we offer insights into the challenges faced by non-experts throughout their qualitative practices, and provide guidance for researchers designing systems to support engagement in these practices.
Coronavirus Multiplication Strategy I. Identification and Characterization of Virus-Specified RNA

We examined the synthesis of intracellular RNA in primary chicken embryo kidney cells infected with the avian coronavirus infectious bronchitis virus. Infected cells were labeled with 32Pi in the presence of actinomycin D for the duration of the viral multiplication cycle, and nucleic acids were extracted, denatured, and analyzed on agarose slab gels. Six major RNA species were found. None of these RNAs was found in extracts of mock-infected cells. All six of the virus-specified RNAs (designated species A through F) were single stranded, and RNA species F had the same electrophoretic mobility as purified viral genome RNA. The molecular weights of the five subgenomic RNAs were estimated to be 0.8 × 106, 0.9 × 106, 1.3 × 106, 1.5 × 106, and 2.6 × 106 for species A through E, respectively. All of the RNAs were polyadenylated and are therefore likely to be viral mRNA's. The RNAs were synthesized in approximately constant proportions throughout the viral multiplication cycle. Intracellular RNA species A, B, C, D, and F and the purified viral genome were analyzed by RNase T1 fingerprinting. The results confirmed the identification of RNA species F as the intracellular genome and the derivation of the four smaller RNAs from the genome. Fingerprinting also showed that the intracellular RNAs constitute a nested set such that the nucleotide sequence of each RNA is contained within all larger RNAs and each larger RNA contains an additional sequence congruent with its greater size. Finally, the possible modes of transcription and translation of the infectious bronchitis virus RNAs are discussed.
Complex Mhc-based mate choice in a wild passerine

The extreme polymorphism of the vertebrate major histocompatibility complex (Mhc) is famous for protecting hosts against constantly evolving pathogens. Mate choice is often evoked as a means of maintaining Mhc variability through avoidance of partners with similar Mhc alleles or preference for heterozygotes. Evidence for these two hypotheses mostly comes from studies on humans and laboratory mice. Here, we tested these hypotheses in a wild outbred population of house sparrows (Passer domesticus). Females were not more or less closely related to the males they paired with when considering neutral genetic variation. However, males failed to form breeding pairs when they had too few Mhc alleles and when they were too dissimilar from females at Mhc loci (i.e. had no common alleles). Furthermore, pairs did not form at random as Mhc diversity positively correlated in mating pairs. These results suggest that mate choice evolves in response to (i) benefits in terms of parasite resistance acquired from allelic diversity, and (ii) costs associated with the disruption of co-adapted genes.
Dense 3-D Structure from Image Sequences Using Probabilistic Depth Carving

We describe an algorithm to determine dense 3-D structure in a static scene from an image sequence captured by a moving camera. Metric camera motions are first determined using a recursive structure from motion algorithm based on tracked feature points. Dense depth information for a subset of key frames is then obtained using a novel probabilistic depth carvingalgorithm - analogous to space carving - in which depth probabilities obtained locally about the key frames are combined in 3-D space. An important component in this process is that opacity and occlusion relationships are modelled explicitly, enabling consistent combination of the depth probabilities. Results of experiments on a real sequence illustrate the effectiveness of the approach.
Exploring the potential of tangible user interface in classroom teaching — Learning

Technology driven modern education system highly depends on the devices which is not an exception in the classrooms. These technological advancements pave new opportunities for creating innovative methods of collaboration depending on gesticulations, body-movements and management of real-objects enhancing higher degree of engagement in classroom. Tangible user interfaces can be noteworthy to the educational environment by empowering the students to interact with virtual objects augmented with the computing power. In this paper, we proposed a system specifying how TUI can be a better alternative in regular classroom teaching learning and explore various possibilities of TUI that can enhance the learning outcome with spontaneous learning zeal. The system also outlines the solution to various problems associated with quality learning in elementary classes. Investigative, design engrossed studies have shown that TUI's offer educational aids, due to the added haptic dimension, shared-space and improved approachability which could be used effectively in collective circumstances.
A survey of social cognitive determinants of physical activity among Iranian women using path analysis method

Summary Introduction This cross-sectional study was carried out on 400 women selected from urban health centers in Isfahan through stratified sampling. The study was designed to evaluate the social cognitive theoretical model in explaining the determinants of physical activity among women using path analysis method. Methods In a hypothetical framework, the relationship between self-efficacy, outcome expectation, social support and self-regulation and physical activity were assessed using path analysis and indices of fitness. Furthermore, the predictive power of the model was evaluated. Results The social cognitive theoretical model had a good predictive power for physical activity. Confirmatory factor analysis revealed the suitability of the theoretical model; this model is able to cover 80% of the physical activity variance. Evaluation of the social cognitive theoretical model using path analysis showed that self-regulation was the strongest determinant of physical activity. Social support and outcome expectation had very weak effects on physical activity; nonetheless, their effect was enhanced by the presence of self-regulation. Self-efficacy had a weak effect on physical activity, however, as an intermediate variable, it reinforced the impact of social support and outcome expectation on physical activity. Conclusions The use of the present hypothetical model is suggested as an appropriate framework in research related to physical activity among women as well as to strengthening self-regulation skills in designing and implementing programs promoting physical activities.
Negative efficacy of fixed gain error reducing shared control for training in virtual environments

Virtual reality with haptic feedback provides a safe and versatile practice medium for many manual control tasks. Haptic guidance has been shown to improve performance of manual control tasks in virtual environments; however, the efficacy of haptic guidance for training in virtual environments has not been studied conclusively. This article presents experimental results that show negative efficacy of haptic guidance during training in virtual environments. The haptic guidance in this study is a fixed-gain error-reducing shared controller, with the control effort overlaid on the dynamics of the manual control task during training. Performance of the target-hitting manual control task in the absence of guidance is compared for three training protocols. One protocol contained no haptic guidance and represented virtual practice. Two protocols utilized haptic guidance, varying the duration of exposure to guidance during the training sessions. Exposure to the fixed-gain error-reducing shared controller had a detrimental effect on performance of the target-hitting task at the conclusion of a month-long training protocol, regardless of duration of exposure. While the shared controller was designed with knowledge of the task and an intuitive sense of the motions required to achieve good performance, the results indicate that the acquisition of motor skill is a complex phenomenon that is not aided with haptic guidance during training as implemented in this experiment.
Investigating the Genetic Circuitry of Mastermind in Drosophila, a Notch Signal Effector

Notch signaling regulates multiple developmental processes and is implicated in various human diseases. Through use of the Notch transcriptional co-activator mastermind, we conducted a screen for Notch signal modifiers using the Exelixis collection of insertional mutations, which affects ∼50% of the Drosophila genome, recovering 160 genes never before associated with Notch, extending the previous roster of genes that interact functionally with the Notch pathway and mastermind. As the molecular identity for most recovered genes is known, gene ontology (GO) analysis was applied, grouping genes according to functional classifications. We identify novel Notch-associated GO categories, uncover nodes of integration between Notch and other signaling pathways, and unveil groups of modifiers that suggest the existence of Notch-independent mastermind functions, including a conserved ability to regulate Wnt signaling.
94 GHz CPW branch-line bandpass filter for planar integrated millimeter-wave circuits

We report the 94 GHz CPW branch-line bandpass filter for planar integrated millimeter- wave circuits. The basic idea is to use the branch-line coupler as a transversal filtering section by connecting the coupled ports to the open load stubs and taking the isolated port as the output node. The 94 GHz bandpass filter exhibits an insertion loss of 2.5 dB with an 11.7 % 3 dB relative bandwidth at a center frequency of 94 GHz and the return loss is better than -18 dB at a center frequency. The designed and fabricated 94 GHz bandpass filter shows the good performance for planar integrated millimeter-wave circuits.
Using a lightweight multimedia content model for semantic annotation

In this paper we discuss the use of a multimedia content model for automatic extraction of semantic metadata from multimedia content. We developed a modular and extensible framework to model the content feature of multimedia data and also describe the way it can be integrated with other existing vocabularies. The goal of this model is to generate sufficient understanding of media content, its context and its relation to domain knowledge in order to perform multimedia reasoning. We implemented a tool that analyzes and links low-level descriptions to higher-level domain specific semantic concepts by means of statistical learning and clustering analysis. Experimental result shows the approach performs well in visual concept prediction in the image which can be further augmented with other information sources such as context text and or audio source.
Hemodynamic Changes following Aortic Valve Bypass: A Mathematical Approach

Aortic valve bypass (AVB) has been shown to be a viable solution for patients with severe aortic stenosis (AS). Under this circumstance, the left ventricle (LV) has a double outlet. The objective was to develop a mathematical model capable of evaluating the hemodynamic performance following the AVB surgery. A mathematical model that captures the interaction between LV, AS, arterial system, and AVB was developed. This model uses a limited number of parameters that all can be non-invasively measured using patient data. The model was validated using in vivo data from the literature. The model was used to determine the effect of different AVB and AS configurations on flow proportion and pressure of the aortic valve and the AVB. Results showed that the AVB leads to a significant reduction in transvalvular pressure gradient. The percentage of flow through the AVB can range from 55.47% to 69.43% following AVB with a severe AS. LV stroke work was also significantly reduced following the AVB surgery and reached a value of around 1.2 J for several AS severities. Findings of this study suggest: 1) the AVB leads to a significant reduction in transvalvular pressure gradients; 2) flow distribution between the AS and the AVB is significantly affected by the conduit valve size; 3) the AVB leads to a significant reduction in LV stroke work; and 4) hemodynamic performance variations can be estimated using the model.
Bony Fusion in a Chronic Cervical Bilateral Facet Dislocation

Patient: Male, 60 Final Diagnosis: Bilateral cervical facet dislocation Symptoms: Neck pain Medication: — Clinical Procedure: — Specialty: Neurosurgery Objective: Unusual clinical course Background: Cervical facet dislocation injuries typically present shortly after occurrence due to the pain and neurologic deficit that can be associated with this injury. Bilateral dislocations of the facet joint require prompt evaluation, reduction, and surgical intervention. Rare case reports present bilateral dislocations presenting in a delayed fashion. Case Report: We report the case of a 60-year-old male who presented with mild neck pain 1 year after initial injury. Computed topography of the cervical spine showed healing with bony fusion of a bilateral C6–7 facet dislocation. Given the chronic healed nature of the injury and minimal symptoms, the patient is being followed without intervention. Conclusions: Although most bilateral facet dislocations present and are treated immediately after injury; this case illustrates that some may be missed during initial evaluation. Once healed, these injuries may be stable without surgical intervention.
Using the Reverse Shock Index at the Injury Scene and in the Emergency Department to Identify High-Risk Patients: A Cross-Sectional Retrospective Study

Background: The ratio of systolic blood pressure (SBP) to heart rate (HR), called the reverse shock index (RSI), is used to evaluate the hemodynamic stability of trauma patients. A SBP lower than the HR (RSI < 1) indicates the probability of hemodynamic shock. The objective of this study was to evaluate whether the RSI as evaluated by emergency medical services (EMS) personnel at the injury scene (EMS RSI) and the physician in the emergency department (ED RSI) could be used as an additional variable to identify patients who are at high risk of more severe injury. Methods: Data obtained from all 16,548 patients added to the trauma registry system at a Level I trauma center between January 2009 and December 2013 were retrospectively reviewed. Only patients transferred by EMS were included in this study. A total of 3715 trauma patients were enrolled and subsequently divided into four groups: group I patients had an EMS RSI ≥1 and an ED RSI ≥1 (n = 3485); group II an EMS RSI ≥ 1 and an ED RSI < 1 (n = 85); group III an EMS RSI < 1 and an ED RSI ≥ 1 (n = 98); and group IV an EMS RSI < 1 and a ED RSI < 1 (n = 47). A Pearson’s χ2 test, Fisher’s exact test, or independent Student’s t-test was conducted to compare trauma patients in groups II, III, and IV with those in group I. Results: Group II and IV patients had a higher injury severity score, a higher incidence of commonly associated injuries, and underwent more procedures (including intubation, chest tube insertion, and blood transfusion in the ED) than patients in group I. Group II and IV patients were also more likely to receive a severe injury to the thoracoabdominal area. These patients also had worse outcomes regarding the length of stay in hospital and intensive care unit (ICU), the proportion of patients admitted to ICU, and in-hospital mortality. Group II patients had a higher adjusted odds ratio for mortality (5.8-times greater) than group I patients. Conclusions: Using an RSI < 1 as a threshold to evaluate the hemodynamic condition of the patients at the injury scene and upon arrival to the ED provides valid information regarding deteriorating outcomes for certain subgroups of patients in the ED setting. Particular attention and additional resources should be provided to patients with an EMS RSI ≥ 1 that deteriorates to an RSI < 1 upon arrival to the ED since a higher odds of mortality was found in these patients.
Increased arterial stiffness and its relationship with inflammation, insulin, and insulin resistance in celiac disease

Objective Celiac disease (CD) is a lifelong, chronic, immune-mediated, inflammatory small bowel disorder, precipitated by exposure to dietary gluten and related proteins in genetically predisposed individuals. Recent studies have shed new light on the importance of inflammation in the pathogenesis of arterial stiffness. The aim of this study was to evaluate arterial stiffness using pulse wave velocity (PWV) in adult CD patients without cardiovascular risk factors in comparison with a control group. Patients and methods A total of 58 patients with CD without cardiovascular risk factors and age-matched and sex-matched healthy controls were enrolled in the study. All patients completed a standard questionnaire form, and various laboratory parameters were assessed. Vascular measurements, including PWV, were carried out using a Mobil-O-Graph 24-h pulse wave analysis monitor, an automatic oscillometric device. Results Although cardiovascular risk factors, such as low-density lipoprotein cholesterol and triglyceride, were significantly lower (P<0.05) in celiac patients than in controls, the erythrocyte sedimentation rate, C-reactive protein, insulin, homeostasis model assessment of insulin resistance, homocysteine, and 24 h, day, and night PWV values were higher in patients with CD than in controls (P<0.05). A multiple linear regression analysis showed that PWV was correlated positively with age and the duration of CD. Conclusion This study found increased arterial stiffness, homocysteine, erythrocyte sedimentation rate, C-reactive protein, insulin, and homeostasis model assessment of insulin resistance in patients with CD and provides evidence for the potential contribution of these parameters and inflammation toward arterial stiffening, independent of conventional cardiovascular risk factors.
Approximation and Exactness in Finite State Optimality Theory

Previous work (Frank and Satta 1998; Karttunen, 1998) has shown that Optimality Theory with gradient constraints generally is not finite state. A new finite-state treatment of gradient constraints is presented which improves upon the approximation of Karttunen (1998). The method turns out to be exact, and very compact, for the syllabification analysis of Prince and Smolensky (1993).
The Effect of Corneal Refractive Surgery on Glaucoma

Laser-assisted refractive procedures have become very popular in the last two decades. As a result, a “generation” of patients with altered corneal properties is emerging. These patients will require both cataract extraction and glaucoma follow-up in the future. Since the glaucoma examination largely depends on the corneal properties, the reshaped postrefractive surgery cornea poses a challenge in the diagnosis, follow-up, and management of the glaucomatous patient. In order to overcome this problem, every patient who is planned to undergo corneal refractive surgery must have a thorough glaucoma examination in order for the ophthalmologist to be able to monitor their patients for possible glaucoma development and/or progression. Some examinations such as tonometry are largely affected by the corneal properties, while others such as the evaluation of the structures of the posterior pole remain unaffected. However, the new imaging modalities of the anterior segment in combination with the most recent advances in tonometry can accurately assess the risk for glaucoma and the need for treatment.