Miracle-dz/UniFAR-FTUs huggingface dataset:
Transidentität im Kindes- und Jugendalter

Aktuell wird eine Diskussion uber die Behandlungsrichtlinien fur transidente Kinder und Jugendliche gefuhrt. Der vorliegende Artikel gibt zunachst eine Ubersicht uber die verschiedenen Behandlungsmasnahmen. Daneben wurden in einer eigenen Untersuchung Patienten aus der Frankfurter Spezialsprechstunde katamnestisch nachuntersucht. Von erfassten 84 Patienten, deren Erstvorstellung mindestens 3 Jahre zurucklag, sandten 37 Patienten ausgefullte Fragebogen zuruck, weitere 33 Patienten waren zu einer kurzen Befragung bereit. Erfragt wurden Behandlungsschritte, Rollenverhalten, Verhaltensauffalligkeiten und Psychotherapieerfahrungen. Es wurde untersucht, ob es Unterschiede in den erfassten Verhaltensauffalligkeiten gibt zwischen Patienten mit und ohne Rollenwechsel und mit viel und wenig Psychotherapie. 22 Patienten hatten sich fur einen vollstandigen Rollenwechsel entschieden und einige davon auch bereits eine Hormontherapie begonnen und sich einer operativen Geschlechtsangleichung unterzogen. Die uberwiegende .
Descents, Peaks, and P -partitions Doctor of Philosophy

Descents, Peaks, and P -partitions A dissertation presented to the Faculty of the Graduate School of Arts and Sciences of Brandeis University, Waltham, Massachusetts by T. Kyle Petersen We use a variation on Richard Stanley’s P -partitions to study “Eulerian” descent subalgebras of the group algebra of the symmetric group and of the hyperoctahedral group. In each case we give explicit structure polynomials for orthogonal idempotents (including q-analogues in many cases). Much of the study of descents carries over similarly to the study of peaks, where we replace the use of Stanley’s P -partitions with John Stembridge’s enriched P -partitions.
A self-adjusting knee exoskeleton for robot-assisted treatment of knee injuries

In this study, we present a novel active device for robot-assisted rehabilitation that accommodates transitional movements of the knee joint as well as its rotation, enabling a perfect match between human joint axes and the device axes. Automatically adjusting its joint axes, the proposed device is not only capable of guaranteeing ergonomy and comfort throughout the therapy, but also extends the usable range of motion for the knee joint. Moreover, the adjustability feature significantly shortens the setup time required to attach the patient to the exoskeleton, allowing more effective time be spend on exercises instead of wasting it for adjustments. The proposed system is different from the similar works in literature in that it supports both passive translational movements of the knee joint and independent active control of these degrees of freedom. In particular, we introduce implementation details of a prototype that features compact design and combines the power of three actuators to achieve high rotational torques, detail the model based impedance controller utilized to adjust interaction forces and present the experimental characterization of the exoskeleton.
Stop Bullying Now! A Federal Campaign for Bullying Prevention and Intervention

This commentary describes a national bullying prevention effort, called Stop Bullying Now! , which aims to increase awareness of the problem of bullying and related research findings, and disseminate evidence-based approaches to prevention. Drawing on the special issue's main theme of the social context of bullying, the author describes the process used to develop the Stop Bullying Now! campaign, highlights the importance of interagency approaches to bullying prevention, and provides examples of social marketing and media activities aimed to prevent bullying on a national scale.
Insulin Acutely Inhibits Intestinal Lipoprotein Secretion in Humans in Part by Suppressing Plasma Free Fatty Acids

OBJECTIVE Intestinal lipoprotein production has recently been shown to be increased in insulin resistance, but it is not known whether it is regulated by insulin in humans. Here, we investigated the effect of acute hyperinsulinemia on intestinal (and hepatic) lipoprotein production in six healthy men in the presence and absence of concomitant suppression of plasma free fatty acids (FFAs). RESEARCH DESIGN AND METHODS Each subject underwent the following three lipoprotein turnover studies, in random order, 4–6 weeks apart: 1) insulin and glucose infusion (euglycemic-hyperinsulinemic clamp) to induce hyperinsulinemia, 2) insulin and glucose infusion plus Intralipid and heparin infusion to prevent the insulin-induced suppression of plasma FFAs, and 3) saline control. RESULTS VLDL1 and VLDL2-apoB48 and -apoB100 production rates were suppressed by 47–62% by insulin, with no change in clearance. When the decline in FFAs was prevented by concomitant infusion of Intralipid and heparin, the production rates of VLDL1 and VLDL2-apoB48 and -apoB100 were intermediate between insulin and glucose infusion and saline control. CONCLUSIONS This is the first demonstration in humans that intestinal apoB48-containing lipoprotein production is acutely suppressed by insulin, which may involve insulin's direct effects and insulin-mediated suppression of circulating FFAs.
Searching for Solutions: The Evolution of an Integrated Approach to Understanding and Mitigating Human–Elephant Conflict in Africa

Human–elephant conflict (HEC) is widespread in Africa and occurs across all biogeographical regions of the species range. HEC involves not only agricultural losses, but also a complex social dimension in the most affected sector, subsistence farming. Agricultural losses involve damage to food crops, cash crops, and even food in storage, with absorption of any loss at the individual household level. The associated social costs are intangible, difficult to quantify, and highly significant. Elephants are a convenient medium for widespread and persistent complaint from rural communities against wildlife conservation initiatives. HEC displays complex spatial dynamics across landscapes. Nearly a decade of investigation coordinated by the IUCN AfESG has revealed several key principles for HEC mitigation. The approach to dealing with this problem needs to be applied at a variety of management scales and is as much an art as a science.
On The Magic of Your Mind

Searching for a lot of marketed publication or reading source in the world? We offer them all in layout type as word, txt, kindle, pdf, zip, rar and ppt. one of them is this certified the magic in your mind that has been created by Still puzzled the best ways to get it? Well, just check out online or download by registering in our website here. Click them. Are you looking to uncover the magic in your mind Digitalbook. Correct here it is possible to locate as well as download the magic in your mind Book. We've got ebooks for every single topic the magic in your mind accessible for download cost-free. Search the site also as find Jean Campbell eBook in layout. We also have a fantastic collection of information connected to this Digitalbook for you. As well because the best part is you could assessment as well as download for the magic in your mind eBook Have free times? Read the magic in your mind writer by Why? A best seller book in the world with terrific worth and material is integrated with interesting words. Where? Simply right here, in this site you can review online. Want download? Naturally available, download them additionally below. Available files are as word, ppt, txt, kindle, pdf, rar, as well as zip. GO TO THE TECHNICAL WRITING FOR AN EXPANDED TYPE OF THIS THE MAGIC IN YOUR MIND, ALONG WITH A CORRECTLY FORMATTED VERSION OF THE INSTANCE MANUAL PAGE ABOVE.
‘Chocolate … makes you autism’: impairment, disability and childhood identities

This paper discusses perceptions and experiences of impairment and disability from the perspectives of learning disabled children, their parents and their social workers. The author reports on findings from her doctoral study that adults often fail to take into account the views and experiences of learning disabled children. As a result, these children developed their own interpretations of impairment and disability based on their experiences and interactions with others. Whilst this indicates that they are active social interpreters, it also suggests that adults should make greater efforts to inform and consult learning disabled children. The author concludes by reflecting on the relevance of these findings to contemporary theories of disability and childhood.
Structural Modifications of the Brain in Acclimatization to High-Altitude

Adaptive changes in respiratory and cardiovascular responses at high altitude (HA) have been well clarified. However, the central mechanisms underlying HA acclimatization remain unclear. Using voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) with fractional anisotropy (FA) calculation, we investigated 28 Han immigrant residents (17–22 yr) born and raised at HA of 2616–4200 m in Qinghai-Tibetan Plateau for at least 17 years and who currently attended college at sea-level (SL). Their family migrated from SL to HA 2–3 generations ago and has resided at HA ever since. Control subjects were matched SL residents. HA residents (vs. SL) showed decreased grey matter volume in the bilateral anterior insula, right anterior cingulate cortex, bilateral prefrontal cortex, left precentral cortex, and right lingual cortex. HA residents (vs. SL) had significantly higher FA mainly in the bilateral anterior limb of internal capsule, bilateral superior and inferior longitudinal fasciculus, corpus callosum, bilateral superior corona radiata, bilateral anterior external capsule, right posterior cingulum, and right corticospinal tract. Higher FA values in those regions were associated with decreased or unchanged radial diffusivity coinciding with no change of longitudinal diffusivity in HA vs. SL group. Conversely, HA residents had lower FA in the left optic radiation and left superior longitudinal fasciculus. Our data demonstrates that HA acclimatization is associated with brain structural modifications, including the loss of regional cortical grey matter accompanied by changes in the white matter, which may underlie the physiological adaptation of residents at HA.
8.1 Review 8.2 Exp3

In the previous lecture we began looking at algorithms for dealing with sequential decision problems in the bandit (or partial) feedback model. In this model, there are K “arms” indexed by 1, 2, . ,K, each with an associated payoff function ri(t) which is unknown. In each round t, an arm i is chosen and the reward ri(t) ∈ [0, 1] is gained. Only ri(t) is revealed to the algorithm at the end of round t, where i is the arm chosen in that round; it is kept ignorant of rj(t) for all other arms j 6= i. The goal is to find an algorithm specifying how to choose an arm in each round that will maximize the total reward over all rounds. We began our study of this model with an assumption of stochastic rewards, as opposed to the harder adversarial rewards case. Thus we assume there is an underlying distribution Ri for each arm i, and each ri(t) is drawn from Ri independently of all other rewards (both of arm i during rounds other than t, and of other arms during round t). Note we assume the rewards are bounded; specifically, ri(t) ∈ [0, 1] for all i and t. We first explored the t-Greedy algorithm in which with probability t an arm is chosen uniformly at random, and with probability 1− t the arm with the highest observed average reward is chosen. For the right choice of t, this algorithm has expected regret logarithmic in T .
The inner entrepreneur: A constructivistic view of entrepreneurial reality construction

Abstract Taking a constructivistic perspective on entrepreneurship will give more comprehensive understandings of the entrepreneurial process. While there is no best answer to entrepreneurship, this article highlights the importance of factoring in the inner conditions of the entrepreneur to understand the phenomenon of entrepreneurship better. Entrepreneurs act on the basis of personalized understandings and emotions, and it is argued herein that the source of entrepreneurship is the inner conditions of the individual entrepreneur, and his/her constructed realities and identity.
Family structure, parental practices and high school completion.

Integrating ideas from child development with sociological models of educational attainment, the AA. examine the relationship between family structure―whether both parents are present in the household―and children's achievement in high school. Using data from the High School and Beyond study, sophomore cohort, 1986, they ask whether differences in achievement are accounted for by differences in parents' educational aspirations and parenting styles. Children who live with single parents or stepparents during adolescence receive less encouragement and less help with school work than children who live with both natural parents, and parental involvement has positive effects on children's school achievement. Differences in parental behavior, however, account for little of the difference in educational attainment between children from intact and nonintact families
Neighborhood Physical Features and Relationships With Neighbors

The objective was to investigate associations between features of the physical environment and neighborliness. Measures of the physical environment, including sidewalks, front porches, traffic-calming devices, bars on windows, and the presence of litter or graffiti, were collected using a systematic audit instrument in 10 neighborhoods in Portland, Oregon. Generalized linear regression models were created to model the odds of increasing neighborliness given access to the physical-environment factors of interest. The authors observed a greater probability of higher levels of neighborliness as the total number of positive physical-environment characteristics increased (cumulative odds ratio [95% confidence interval] = 1.69 [1.16, 2.45]) and the results were unchanged after controlling for race, self-reported health, perception of safety, years of neighborhood residence, age of house, market value of house, and proportion of homeowners in neighborhood. Modifiable features of the physical environment may be one mechanism through which people can enhance neighborliness.
The CODASYL and GUIDE/SHARE proposals on data base management systems

Six panelists will discuss the subject of Data Base Management (DBM) as it relates to CODASYL's Data Base Language Task Group report and Data Definition Language Committee Report and the GUIDE/SHARE published requirements for a DBM and other published GUIDE documents deemed pertinent. Four key issues that best deal with the philosophy, concepts and differences of the CODASYL and GUIDE/SHARE work to date will be addressed.
Antecedents of the Theory Movement

This article traces the conceptual roots of the theory movement in educational administration. Ideas of Auguste Comte, father of positivism, and of the logical positivists are highlighted. How core concepts which shaped the theory movement were diffused into educational administration is documented. Finally, the paper sets forth implications for the future study of educational administration. The article is based on a paper presented toa UCEA-Universityof Wisconsin sponsored Career Develop ment Seminar held in memory of the late William J. Davis, former EAQ Editorial Board member, at Madison, Wisconsin, March 1980.
Induction of tenascin in healing wounds

The distribution of the extracellular matrix glycoprotein, tenascin, in normal skin and healing skin wounds in rats, has been investigated by immunohistochemistry. In normal skin, tenascin was sparsely distributed, predominantly in association with basement membranes. In wounds, there was a marked increase in the expression of tenascin at the wound edge in all levels of the skin. There was also particularly strong tenascin staining at the dermal-epidermal junction beneath migrating, proliferating epidermis. Tenascin was present throughout the matrix of the granulation tissue, which filled full-thickness wounds, but was not detectable in the scar after wound contraction was complete. The distribution of tenascin was spatially and temporally different from that of fibronectin, and tenascin appeared before laminin beneath migrating epidermis. Tenascin was not entirely codistributed with myofibroblasts, the contractile wound fibroblasts. In EM studies of wounds, tenascin was localized in the basal lamina at the dermal-epidermal junction, as well as in the extracellular matrix of the adjacent dermal stroma, where it was either distributed homogeneously or bound to the surface of collagen fibers. In cultured skin explants, in which epidermis migrated over the cut edge of the dermis, tenascin, but not fibronectin, appeared in the dermis underlying the migrating epithelium. This demonstrates that migrating, proliferating epidermis induces the production of tenascin. The results presented here suggest that tenascin is important in wound healing and is subject to quite different regulatory mechanisms than is fibronectin.
Exposed Water Ice Deposits on the Surface of Comet 9P/Tempel 1

We report the direct detection of solid water ice deposits exposed on the surface of comet 9P/Tempel 1, as observed by the Deep Impact mission. Three anomalously colored areas are shown to include water ice on the basis of their near-infrared spectra, which include diagnostic water ice absorptions at wavelengths of 1.5 and 2.0 micrometers. These absorptions are well modeled as a mixture of nearby non-ice regions and 3 to 6% water ice particles 10 to 50 micrometers in diameter. These particle sizes are larger than those ejected during the impact experiment, which suggests that the surface deposits are loose aggregates. The total area of exposed water ice is substantially less than that required to support the observed ambient outgassing from the comet, which likely has additional source regions below the surface.
Manganese(II)-bicarbonate-mediated catalytic activity for hydrogen peroxide dismutation and amino acid oxidation: detection of free radical intermediates.

To examine the structural identities of reactive free radicals and the mechanism of the oxidative modification of proteins, we used EPR and spin-trapping methods to investigate the oxidation of amino acids by H2O2 as well as the decomposition of H2O2 itself catalyzed by Mn(II) ions. Superoxide and hydroxyl radicals (O2-. and OH.) were trapped by a spin trap, 5,5-dimethyl-1-pyrroline-1-oxide (DMPO), in a reaction mixture containing Mn(II) and H2O2 in bicarbonate/CO2 buffer. When Hepes was used in place of bicarbonate buffer, superoxide radical was not observed, indicating the importance of bicarbonate buffer. With addition of L-leucine to a similar reaction mixture, a leucine-derived radical that replaced the DMPO-superoxide adduct was detected in the absence and presence of DMPO. Using various isotope-enriched L-leucines, we successfully identified this radical as a hydronitroxide, -OOC(R)CHNHO. The data are consistent with the formation of a transient "caged" OH. in the inner coordination sphere of Mn(II). This caged OH. is likely to undergo an intramolecular hydrogen-atom abstraction from the Mn-bound H2O2 or amino acid. Two reaction schemes are proposed to account for the experimental results shown here and in the preceding papers.
Dual-electrode bimorph pmut arrays for handheld therapeutic medical devices

A CMOS-compatible, aluminum nitride (AlN) based, dual-electrode bimorph piezoelectric micromachined ultrasonic transducer (pMUT) array has been developed. Under an input 5Vac driving voltage, a high acoustic intensity of 30-70mW/cm2 up to 2.5mm deep into tissues can be generated for therapeutic medical applications. The low driving voltage is readily applicable for battery-powered low intensity pulsed ultrasound (LIPUS) medical devices for fracture and tissue healing applications. The fabrication also introduces a novel method using PECVD SiO2 as the barrier layer between AlN films to increase the breakdown voltage and manufacturing yield. Results on a prototype array have shown the highest intensity per voltage squared, per number of pMUTs squared, per piezoelectric constant squared (i.e. In=I/(VNd31)2) among all reported pMUT arrays.
Expression of the Gonococcal Global Regulatory Protein Fur and Genes Encompassing the Fur and Iron Regulon during In Vitro and In Vivo Infection in Women

ABSTRACT The ferric uptake regulatory protein, Fur, functions as a global regulatory protein of gene transcription in the mucosal pathogen Neisseria gonorrhoeae. We have shown previously that several N. gonorrhoeae Fur-repressed genes are expressed in vivo during mucosal gonococcal infection in men, which suggests that this organism infects in an iron-limited environment and that Fur is expressed under these conditions. In this study we have demonstrated expression of the gonococcal fur gene in vitro, in human cervical epithelial cells, and in specimens from female subjects with uncomplicated gonococcal infection. In vitro studies confirmed that the expression of the gonococcal fur gene was repressed during growth under iron-replete growth conditions but that a basal level of the protein was maintained. Using GFP transcriptional fusions constructed from specific Fur binding sequences within the fur promoter/operator region, we determined that this operator region was functional during N. gonorrhoeae infection of cervical epithelial cells. Furthermore, reverse transcription-PCR analysis, as well as microarray analysis, using a custom Neisseria Fur and iron regulon microarray revealed that several Fur- and iron-regulated genes were expressed during N. gonorrhoeae infection of cervical epithelial cells. Microarray analysis of specimens obtained from female subjects with uncomplicated gonococcal infection corroborated our in vitro findings and point toward a key role of gonococcal Fur- and iron-regulated genes in gonococcal disease.
Sir2 plays a key role in cell fate determination upon SAPK activation

Although the benefit of sirtuin activation in age-related diseases is well-characterized, the benefit of sirtuin activation in acute diseases has been elusive. Here we discuss that, at least in yeast, Sir2 activation prevents programmed cell death induced by the sustained activation of the stress activated protein kinase (SAPK) Hog1, the yeast homologue of the p38 SAPK. Sir2 prevents ROS formation and maximize cell survival upon SAPK activation. The conserved function of Sir2 in age-related diseases and the conserved role of SAPKs open the possibility of a novel role for sirtuins in cell fate determination in eukaryotic cells.
A confidence-based active approach for semi-supervised hierarchical clustering

Semi-supervised approaches have proven to be effective in clustering tasks. They allow user input, thus improving the quality of the clustering obtained, while maintaining a controllable level of user intervention. Despite being an important class of algorithms, hierarchical clustering has been little explored in semisupervised solutions. In this report, we address the problem of semi-supervised hierarchical clustering by using an active clustering solution with cluster-level constraints. This active learning approach is based on a new concept of merge confidence in an agglomerative clustering process. When there is lower confidence in a cluster merge the user can be queried and provide a clusterlevel constraint. The proposed method was compared with a unsupervised algorithm (average-link) and a semi-supervised algorithm based on pairwise constraints. The results show that our algorithm tends to be better than the pairwise constrained algorithm and can achieve a significant improvement when compared to the unsupervised algorithm.