Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of Auditory Processing and Cognitive Abilities in Children

Objectives: To examine the links between auditory processing (AP) test results, functional deficits, and cognitive abilities. Design: One hundred and fifty-five children, ages 7–12 years, comprising 50 control children and 105 children referred for AP assessment, all with normal peripheral hearing, completed an AP and cognitive (sustained attention, auditory working memory, and nonverbal intelligence) test battery. Functional outcome measures of listening ability (developed using questionnaires from parent, teacher, and child respondents) and reading fluency were also collected. Results: AP scores for dichotic digits, frequency pattern, and listening in spatialized noise-sentences test baseline scores showed significant intertask correlations, and significant correlations with functional outcomes. The gaps in noise task showed correlation with reading fluency only. The AP tasks of masking level differences and spatial advantage showed no correlation with listening ability or reading fluency. Results showed significantly poorer cognitive abilities overall in the children referred for AP assessment compared with the control group. Within the referred group, children diagnosed with an auditory processing disorder had significantly poorer cognitive abilities than those passing the test battery. Correlation and regression studies showed significant associations between AP and cognitive scores. The results of multilinear regression analyses showed that the associations of AP scores with listening and academic results were no longer significant when cognitive scores were also included as predictors. Conclusions: A complex interaction of cognitive abilities and AP scores is evident. For many children with listening difficulties, who perform poorly on AP tasks, cognitive deficits are also in place. Although the direction of causality is unclear, it is likely that these cognitive deficits are causing the perceived difficulty and/or are having a significant effect on the test results. Interpretation of AP tests requires consideration of how cognitive abilities may have impacted on not only task results but also the functional difficulties experienced by the child.
Failure Size Proportional Models and an Analysis of Failure Detection Abilities of Software Testing Strategies

This paper combines two distinct areas of research, namely software reliability growth modeling, and efficacy studies on software testing methods. It begins by proposing two software reliability growth models with a new approach to modeling. These models make the basic assumption that the intensity of failure occurrence during the testing phase of a piece of software is proportional to the s-expected probability of selecting a failure-causing input. The first model represents random testing, and the second model represents partition testing. These models provide the s-expected number of failures over a period, which in turn is used in analyzing the failure detection abilities of testing strategies. The specific areas of investigation are *) conditions that enable partition testing yielding optimal results, and) comparison between partition testing and random testing in terms of efficacy
Oral health and access to dental care: a qualitative investigation among older people in the community.

OBJECTIVE The aim of this study was to explore older persons' beliefs and attitudes towards oral health and access to and use of dental care services. BACKGROUND As the proportion of dentate older people increases, the need and demand for dental services will rise (J Public Health Dent, 60, 2000, 276). DESIGN Focus groups and semi-structured interviews were used for data collection. SETTING AND SUBJECTS The study participants included 63 older people in Perth, WA. RESULTS Five major themes emerged from the interviews - the need for information and knowledge; accessibility of services; cost and affordability of oral care; fear and anxiety regarding dental visits and relationships with dentists. Attitudes and behaviours were slow to change in this group. CONCLUSION This investigation provided important perspectives regarding oral health and dental access for older people residing in the community and demonstrated the importance of understanding this group when considering provision and use of services.
Do clusters really matter for innovation practices in Information Technology? Questioning the significance of technological knowledge spillovers

A widespread assumption in economic geography and the economics of innovation is that firms located in clusters benefit from territorial learning and knowledge spillovers. However, it remains unclear to what extent these benefits actually occur. This paper aims to address this issue and examines to what extent research and development (RD in particular they concern labour market advantages and benefits from the global ‘brand’ of Cambridge.
Folding simulations of Trp‐cage mini protein in explicit solvent using biasing potential replica‐exchange molecular dynamics simulations

Replica exchange molecular dynamics (RexMD) simulations are frequently used for studying structure formation and dynamics of peptides and proteins. A significant drawback of standard temperature RexMD is, however, the rapid increase of the replica number with increasing system size to cover a desired temperature range. A recently developed Hamiltonian RexMD method has been used to study folding of the Trp‐cage protein. It employs a biasing potential that lowers the backbone dihedral barriers and promotes peptide backbone transitions along the replica coordinate. In two independent applications of the biasing potential RexMD method including explicit solvent and starting from a completely unfolded structure the formation of near‐native conformations was observed after 30–40 ns simulation time. The conformation representing the most populated cluster at the final simulation stage had a backbone root mean square deviation of ∼1.3 Å from the experimental structure. This was achieved with a very modest number of five replicas making it well suited for peptide and protein folding and refinement studies including explicit solvent. In contrast, during five independent continuous 70 ns molecular dynamics simulations formation of collapsed states but no near native structure formation was observed. The simulations predict a largely collapsed state with a significant helical propensity for the helical domain of the Trp‐cage protein already in the unfolded state. Hydrogen bonded bridging water molecules were identified that could play an active role by stabilizing the arrangement of the helical domain with respect to the rest of the chain already in intermediate states of the protein. Proteins 2009. © 2008 Wiley‐Liss, Inc.
A MODEL FOR TYPE 2 CORONAL LINE FOREST (CLiF) AGNs

We present a model for the classification of Coronal Line Forest Active Galactic Nuclei (CLiF AGNs). CLiF AGNs are of special interest due to their remarkably large number of emission lines, especially forbidden high-ionization lines (FHILs). Rose et al. suggest that their emission is dominated by reflection from the inner wall of the obscuring region rather than direct emission from the accretion disk. This makes CLiF AGNs laboratories to test AGN-torus models. Modeling an AGN as an accreting supermassive black hole surrounded by a cylinder of dust and gas, we show a relationship between the viewing angle and the revealed area of the inner wall. From the revealed area, we can determine the amount of FHIL emission at various angles. We calculate the strength of [Fe vii]λ6087 emission for a number of intermediate angles (30°, 40°, and 50°) and compare the results with the luminosity of the observed emission line from six known CLiF AGNs. We find that there is good agreement between our model and the observational results. The model also enables us to determine the relationship between the type 2:type 1 AGN fraction vs the ratio of torus height to radius, h/r.
Novel investigational therapies for atopic dermatitis

Introduction: Atopic dermatitis (AD) is a common skin disease. Although most patients are well served by existing therapies, a subset of patients with severe AD are still not adequately treated. An improved understanding of the pathogenic mechanisms behind the disease has led to the development of a range of potential new drugs for this indication. Areas covered: The authors provide a narrative review of the drugs in Phase II trials listed on Clinicaltrials.gov. The authors supplement this information with recently published literature located through PubMed. The main target of new treatments appears to be the inflammation process, whereas drugs aimed at reducing itching or increasing the barrier function are fewer to nonexistent. A wide range of drugs, including small molecules and antibodies, are being tested. Expert opinion: The focus on inflammation is not only driven by the limitations posed by our current understanding of biology, but also by the broader scope of these drugs, which may be used in other diseases. In alignment with the recent drug development of other dermatological diseases, antibodies directed at key molecules in the pathogenesis of AD appear to be the most promising.
You’re Going to Need a Bigger (Glass Bottom) Boat

Alternative processing of ligands in the transforming growth factor–β family may fine-tune signaling outputs. Signaling molecules of the transforming growth factor (TGF)–β family are generated from proprotein precursors containing prodomain sequences that are typically removed to allow signaling by the mature ligands. A form of a TGF-β family ligand that remains covalently attached to its prodomain but retains signaling activity has been identified. Glass bottom boat (Gbb), a Drosophila homolog of the bone morphogenetic protein 5/6/7/8 subfamily, is active as a carboxyl-terminal fragment of the proprotein (Gbb15) that is generated by a conventional processing event common to TGF-β ligands. Unexpectedly, a larger form (Gbb38) produced by processing at a newly identified furin site in the prodomain is also secreted and active. Contrary to the present paradigm in which TGF-β ligands require dissociation of the entire prodomain for activity, Gbb38 is active in cell culture and in vivo without additional processing at conventional sites. The large form can restore the viability of gbb mutant animals but has distinct signaling properties compared with the conventional form. Production of multiple functional ligands from one proprotein is a potential mechanism to fine-tune TGF-β signaling outputs. Mutations in TGF-β family members have been linked to human diseases, several of which affect potential furin cleavage sites in prodomains. However, given the diversity of potential furin processing sites and prodomain functions, direct experimentation will be required to determine whether production of active jumbo ligands is a general feature of TGF-β superfamily members.
Can Curriculum Ideals be Patched onto Old Garment or Poured into Old Wineskin?

Beane, J. (1997). Curriculum integration: Designing the core of democratic education. New York: Teachers College Press. Bonnett, M. (2007). Environmental education and the issue of nature. Journal of Curriculum Studies, 39, 707–721. Schwartz, M. (2006). For whom do we write the curriculum? Journal of Curriculum Studies, 38, 449–457. Slattery, P., Kasny, K. , & O’Malley, M. (2007). Hermeneutics, aesthetics, and the quest for answerability: A dialogic possibility for reconceptualizing the interpretive process in curriculum studies. Journal of Curriculum Studies, 39, 537–558.
Ecotourism as a conservation tool and its adoption by private protected areas in Brazil

Ecotourism in private reserves combines the establishment of protected areas with an incentive mechanism to conserve biodiversity. Brazil's private reserve system is well-established but little is known about its links to tourism. This study puts the global private protected area into context and quantifies the extent to which ecotourism has been adopted as a sustainable land-use practice on private reserves in Brazil. Our findings demonstrate that small reserves do contribute to conservation and are used for ecotourism. The belief that large reserves are necessary for ecotourism and conservation is challenged. Only 4% (n = 45) of the 1182 reserves are engaged in ecotourism, mainly those within the Atlantic Forest biome and these are generally small in size (<50 ha). Reserves provide modest to basic accommodation as well as education and economic opportunities that include adjacent communities. Hiking and bird watching are the most popular activities but many reserves are threatened by poaching and invasive species. The low adoption of ecotourism appears due to a combination of factors, including lack of landowner interest, constraints imposed by regulations, logistics and anthropogenic threats. Nonetheless, there is potential to expand ecotourism within private reserves as 143 further private reserves are located near those already engaged in ecotourism.
The Problem of Thrombocytopenia after Hematopoietic Stem Cell Transplantation

Thrombocytopenia after hematopoietic stem cell transplantation (HSCT) is associated with an increased risk of bleeding and utilization of significant resources. This review presents an analysis of risk factors associated with delayed platelet engraftment. The retrospective analysis included 1,468 recipients of autologous or allogeneic transplants treated between January 1, 1990 and July 1, 1995. Risk factors associated with delayed platelet engraftment after autologous HSCT included use of marrow rather than peripheral blood as the source of stem cells, being transplanted for acute myeloid leukemia rather than other diseases, positive patient serology for cytomegalovirus and the presence of infection post-transplant before engraftment. Risk factors associated with delayed platelet engraftment after allogeneic marrow transplantation included unrelated as opposed to related donor transplants, being transplanted for diseases other than chronic myelogenous leukemia, increased age, onset of acute graft-versus-host disease (AGVHD), male gender, the administration of methotrexate for GVHD prophylaxis and the presence of infection before engraftment. Delayed platelet recovery is associated with decreased survival after both autologous and allogeneic transplants. Management of delayed platelet recovery by transfusion of blood products requires significant medical resources and is of some risk to the patients. Further development of new strategies may safely reduce the need for blood products. These include peripheral blood stem cell transplants (allogeneic and autologous), new algorithms for administering routine platelet transfusions and investigative biological agents for stimulating megakaryocytopoiesis. Further studies may elucidate the cause of increased platelet consumption associated with infection and GVHD.
PUBLIC AND PRIVATE SECTOR MANAGERS OVER 20 YEARS: A TEST OF THE ‘CONVERGENCE THESIS’

This paper sets out to test the ‘convergence thesis’ in respect of managers in the public and private sectors in Britain. New Public Management (NPM) initiatives have had the objective of making managerial behaviour in public sector organizations more similar to that in the private sector. Based on unique national surveys undertaken in 1980, 1990 and 2000, using quite large random samples of fellows and members of the Chartered Management Institute (CMI), comparisons are made to investigate whether ‘convergence’ between public and private sector managers has actually occurred. The patterns are found to be complex and, although there are some signs of convergence, the two sectors continue to exhibit similarities, persistent differences and parallel movements evident in managerial attitudes, behaviour and experiences.
Treatment preferences among depressed primary care patients

AbstractOBJECTIVE: To understand patient factors that may affect the probability of receiving appropriate depression treatment, we examined treatment preferences and their predictors among depressed primary care patients. DESIGN: Patient questionnaires and interviews. SETTING: Forty-six primary care clinics in 7 geographic regions of the United States. PARTICIPANTS: One thousand one hundred eighty-seven English-and Spanish-speaking primary care patients with current depressive symptoms. MEASUREMENTS AND MAIN RESULTS: Depressive symptoms and diagnoses were determined by the Composite International Diagnostic Interview (CIDI) and the Center for Epidemiological Studies Depression Scale (CES-D). Treatment preferences and characteristics were assessed using a self-administered questionnaire and a telephone interview. Nine hundred eight-one (83%) patients desired treatment for depression. Those who preferred treatment were wealthier (odds ratio [OR], 3.7; 95% confidence interval [95% CI], 1.8 to 7.9; P=.001) and had greater knowledge about antidepressant medication (OR, 2.6; 95% CI, 1.6 to 4.4; P≤.001) than those who did not want treatment. A majority (67%, n=660) of those preferring treatment preferred counseling, with African Americans (OR, 2.2; 95% CI, 1.0 to 4.8, P=.04 compared to whites) and those with greater knowledge about counseling (OR, 2.1; 95% CI, 1.6 to 2.7, P≤.001) more likely to choose counseling. Three hundred twelve (47%) of the 660 desiring counseling preferred group over individual counseling. Depression severity was only a predictor of preference among those already in treatment. CONCLUSIONS: Despite low rates of treatment for depression, most depressed primary care patients desire treatment, especially counseling. Preferences for depression treatment vary by ethnicity, gender, income, and knowledge about treatments.
Activation of host cell protein kinase C by enteropathogenic Escherichia coli

Enteropathogenic Escherichia coli (EPEC) consists of a group of diarrhea-producing E. coli strains, common in developing countries, which do not produce classical toxins and are not truly invasive. EPEC strains adhere to mammalian cells in an intimate fashion, trigger a localized increase in intracellular calcium levels, and elevate inositol phosphate production. We hypothesized that these mediators could activate host cell protein kinase C (PKC) and tested this idea in vitro with two cultured human cell lines, HeLa cells and T84 cells. Using a recently described subculturing protocol to "induce" or accelerate EPEC adherence, we infected the cells with EPEC at a multiplicity of infection of approximately 100:1 for 30 to 60 min. Under these conditions, EPEC E2348 increased membrane-bound PKC activity 1.5- to 2.3-fold in HeLa cells and T84 cells, respectively. The increase in membrane-bound PKC activity was accompanied by a decrease in cytosolic PKC activity in EPEC-infected HeLa cells. Nonadherent laboratory E. coli strains such as HB101 and H.S. failed to trigger any consistent change in PKC production, similar to the nonadherent mutant strains derived from E2348, JPN15 (plasmid cured) and CVD206 (eaeA). In addition, immunoblots performed on extracts of T84 cells with a monoclonal antibody against PKC-alpha showed an increased PKC content in membranes of EPEC-infected cells. Finally, EPEC-infected T84 cells showed a 60% increase in responsiveness to the E. coli heat-stable toxin. We conclude that mediators produced in response to EPEC adherence activate PKC in intestinal and nonintestinal cells.
Steroids as Part of Combination Treatment: The Future for the Management of Macular Edema?

Diabetic macular edema (DME), defined as a retinal thickening involving or approaching the center of the macula, plays a major role in vision loss related to diabetic retinopathy. This article presents an in-depth analysis of therapeutic perspectives on DME by means of an approach based on combination therapy with steroids. Corticosteroid drugs have been demonstrated to both inhibit the expression of vascular endothelial growth factor (VEGF) and the VEGF gene, and to have antiinflammatory properties. A treatment algorithm is provided regarding the management of DME. While grid laser photocoagulation remains the first-line therapy for focal vasogenic DME, diffuse DME can be effectively treated by means of intravitreal injections of corticosteroids. Recalcitrant DME can also be managed beneficially with intravitreal steroids. The management of DME is complex, and often multiple treatment approaches are needed. Each form of DME should be properly classified and specifically treated. The combination treatment has still an important role in the combined treatment options for DME.
Task Analysis-Based User Event Logging for Mobile Applications

Task analysis defines the user-centered tasks that users will carry out to use a system, and it serves as the basis for the definition of usability requirements related to efficiency and effectiveness. Usability and UX (User eXperience) are especially important for mobile application development. We aim to provide support to task modelling for Android application development, and to specify user events to be logged for further analysis. Selection of the task modelling technique has been carried out in a two steps approach, allowing, for the next step of developing, a tool to support task modelling and annotation.
Industrial energy intensities in the UK: is there a deterministic or stochastic difference among sectors?

Energy intensities of industrial subsectors differ widely due to differences in the final product and ultimately in the production process. The aim of this article is to assess whether these differences are stochastic or deterministic. The analysis is implemented for a number of British industrial subsectors over the 1970–2004 and 1978–2004 time periods. It turns out that the results of the tests are very influenced by whether one allows for the presence of structural breaks. Only when modelling structural breaks, one can conclude that the evidence in favour of the long-term differences being deterministic outbalances the evidence pointing to their nature being stochastic. This supports the adoption of policy instruments which are applied across productive sectors in a way which is not affected by the short-run evolution of the sectors.
Fuzzy Financial Pricing of Property-Liability Insurance

This paper uses fuzzy set theory (FST) to solve a problem in actuarial science, the financial pricing of property-liability insurance contracts. The fundamental concept of FST is the alternative formalization of membership in a set to include the degree or strength of membership. FST provides consistent mathematical rules for incorporating vague, subjective, or judgmental information into complex decision processes. It is potentially important in insurance pricing because much of the information about cash flows, future economic conditions, risk premiums, and other factors affecting the pricing decision is subjective and thus difficult to quantify by using conventional methods. To illustrate the use of FST, we “fuzzify” a well-known insurance financial pricing model, provide numerical examples of fuzzy pricing, and propose rules for project decision-making using FST. The results indicate that FST can lead to significantly different decisions than the conventional approach.
Redesigning Medical Education to Improve Health Care Delivery and Outcomes

The need to improve the health of individuals and populations by providing high-quality health care has become a priority and has led to the implementation of various quality indicators to measure performance and outcomes. However, significant disparities exist in the health care delivery and outcomes among individuals that can only intensify, considering the future projections for an aging and increasingly diverse population. This article provides the authors’ perspectives on how these issues can be addressed and overcome by redesigning medical education so the future generations of physicians have the necessary knowledge, skills, and attitudes to provide high-quality, patient-centered, and culturally sensitive care.