Miracle-dz/UniFAR-FTUs huggingface dataset:
Acute Effects of 30 g Cyclodextrin Intake during CrossFit® Training on Performance and Fatigue

The main objective of this study was to investigate the influence of carbohydrate intake (cyclodextrin) on performance during the performance of two consecutive workouts of the day (WODs) lasting 20 min each. Twenty-one male CrossFit (CF) athletes (29.5 ± 4.3 years; 72.81 ± 12.85 kg; 1.74 ± 0.06 m; 3.41 ± 1.21 years of experiences) participated in a crossover, randomized, and double-blind study. The effect of supplementation with 30 g of cyclodextrin (SG) (Cluster Dextrin®) or placebo (PG) (Bolero Advanced Hydration®) was evaluated on the performance of two specific WOD. Additionally, the effect on handgrip maximum strength, countermovement jump (CMJ), Wingate test, and 1 RM bench press test was evaluated. The effect on blood glucose and lactate was also evaluated. No differences were found in time, height, and power (W/Kg) in CMJ. However, there was a percentage improvement in CMJ jump power (W) (p < 0.05) between the groups, assuming an improvement in performance due to the intervention. Moreover, both conditions experimented differences in execution speed between sets (p < 0.05) in pre-WOD, and differences in post-WOD only in the placebo group, as well as decreases in this variable per repetition across the set (p < 0.01) in both conditions. However, no differences were found in the rest of the variables. Supplementation with 30 g of cyclodextrin did not have any metabolic or performance effects in CF tests. Although some differences between groups were observed in CMJ and power tests for bench press, the data are not conclusive and further research is needed in this regard.
The analysis of the results of aerial photography experiments on the basis of a developed UAV model

Modern techniques related to the creation of topographic and cadastral plans of land areas are based on the use of digital data received as a result of aerial photography. This article discusses three core technological issues in the application of UAVs in topographic aerial photography connected to the stabilization of the UAV during the flight: maintenance of a constant speed, maintenance of a straight line of flight and the reduction of tilt. This article presents the results of a study of the aerial photography errors and describes the ways in which the latter can be addressed.
Selective sodium-glucose cotransporter-2 inhibitors in the improvement of hemoglobin and hematocrit in patients with type 2 diabetes mellitus: a network meta-analysis

Objective To compare the effects of different selective sodium-glucose cotransporter-2 inhibitors (SGLT2i) on hemoglobin and hematocrit in patients with type 2 diabetes mellitus (T2DM) with a network meta-analysis (NMA). Methods Randomized controlled trials (RCTs) on SGLT2i for patients with T2DM were searched in PubMed, Embase, Cochrane Library, and Web of Science from inception of these databases to July 1, 2023. The risk of bias (RoB) tool was used to evaluate the quality of the included studies, and R software was adopted for data analysis. Results Twenty-two articles were included, involving a total of 14,001 T2DM patients. SGLT2i included empagliflozin, dapagliflozin, and canagliflozin. The NMA results showed that compared with placebo, canagliflozin 100mg, canagliflozin 300mg, dapagliflozin 10mg, dapagliflozin 2mg, dapagliflozin 50mg, dapagliflozin 5mg, empagliflozin 25mg, and dapagliflozin 20mg increased hematocrit in patients with T2DM, while canagliflozin 100mg, canagliflozin 200mg, canagliflozin 300mg increased hemoglobin in patients with T2DM. In addition, the NMA results indicated that canagliflozin 100mg had the best effect on the improvement of hematocrit, and canagliflozin 200mg had the best effect on the improvement of hemoglobin. Conclusion Based on the existing studies, we concluded that SGLT2i could increase hematocrit and hemoglobin levels in patients with T2DM, and canagliflozin 100mg had the best effect on the improvement of hematocrit, while canagliflozin 200mg had the best effect on the improvement of hemoglobin. Systematic review registration https://www.crd. york.ac. uk/PROSPERO/#loginpage, identifier PROSPERO (CRD42023477103).
Interannual variability in the onset of the South China Sea summer monsoon from 1997 to 2014

Abstract Using observed and reanalysis datasets, the South China Sea summer monsoon (SCSSM) onset process is analyzed in each year from 1997 to 2014. Regional mean (5–20°N, 110–120°E) 850 hPa zonal wind, precipitation, and SST are used as indices to describe SCSSM onset. Three distinct onset types are identified: among the 18 years studied, nine are normal onset years, which are characterized by a well-established westerly wind and associated precipitation over the South China Sea (SCS); eight are intermittent onset years, in which monsoon precipitation does not occur continuously following the establishment of the westerly wind over the SCS; and one year, 2014, is a delayed onset year, in which the western Pacific subtropical high dominates over the SCS after the seasonal transition and prevents the monsoon onset. A comparison of the first two types suggests that a positive SST gradient in the northern Indian Ocean and local SST warming in the SCS are two key factors in the normal SCSSM onset type. With regard to the influence of the El Niño–Southern Oscillation background, there are four late onset years (1997, 1998, 2007, and 2010) that coincide with El Niño events, but only two early-onset years (1999 and 2012) out of the six years featuring La Niña events. Further analysis suggests that the zonal thermal contrast across the Indian and western Pacific oceans modulates monsoon onset in La Niña years.
Research data supporting “PoseNet: A Convolutional Network for Real-Time 6-DOF Camera Relocalization”: St Marys Church

St Mary's Church scene from Cambridge Landmarks, a large scale outdoor visual relocalisation dataset taken around Cambridge University. Contains original video, with extracted image frames labelled with their 6-DOF camera pose and a visual reconstruction of the scene. If you use this data, please cite our paper: Alex Kendall, Matthew Grimes and Roberto Cipolla "PoseNet: A Convolutional Network for Real-Time 6-DOF Camera Relocalization. " Proceedings of the International Conference on Computer Vision (ICCV), 2015.
Research and development of probabilistic risk assessment methodology for combination event of low temperature and snow

The objective of this study is to develop probabilistic risk assessment (PRA) methodology for combination event of low temperature and snow by focusing on decay heat removal system (DHRS) of sodium-cooled fast reactor. For this combination event, annual excess probability depending on the hazard intensity was statistically estimated based on the meteorological data. Event tree was developed by considering the impact of low temperature and snow on DHRS: e.g., plug at the air intake of ultimate heat sink and of emergency diesel generator and unopenable door for access route due to accumulated snow, failure of air intake filter due to deposited snow, possibility of freezing of cooling circuits. Recovery actions (i.e., snow removal and filter replacement) were considered in the event tree. By using annual excess probability and failure probabilities, the event tree was quantified and the quantified event tree showed that dominant core damage sequence is loss of access route for snow removal against the combination event at daily snowfall depth of 3m/day continued during 24h. When the access route is secured for all hazard intensity assumed this paper, it was showed that core damage frequency decreases about 1/10 times and securement of the access route has significant sensitivity to the core damage frequency.
Structural elements defining elongation factor Tu mediated suppression of codon ambiguity

In most prokaryotes Asn-tRNAAsn and Gln-tRNAGln are formed by amidation of aspartate and glutamate mischarged onto tRNAAsn and tRNAGln, respectively. Coexistence in the organism of mischarged Asp-tRNAAsn and Glu-tRNAGln and the homologous Asn-tRNAAsn and Gln-tRNAGln does not, however, lead to erroneous incorporation of Asp and Glu into proteins, since EF-Tu discriminates the misacylated tRNAs from the correctly charged ones. This property contrasts with the canonical function of EF-Tu, which is to non-specifically bind the homologous aa-tRNAs, as well as heterologous species formed in vitro by aminoacylation of non-cognate tRNAs. In Thermus thermophilus that forms the Asp-tRNAAsn intermediate by the indirect pathway of tRNA asparaginylation, EF-Tu must discriminate the mischarged aminoacyl-tRNAs (aa-tRNA). We show that two base pairs in the tRNA T-arm and a single residue in the amino acid binding pocket of EF-Tu promote discrimination of Asp-tRNAAsn from Asn-tRNAAsn and Asp-tRNAAsp by the protein. Our analysis suggests that these structural elements might also contribute to rejection of other mischarged aa-tRNAs formed in vivo that are not involved in peptide elongation. Additionally, these structural features might be involved in maintaining a delicate balance of weak and strong binding affinities between EF-Tu and the amino acid and tRNA moieties of other elongator aa-tRNAs.
Examining the Impact of Group-Based Social Skills Intervention in Autistic Children Aged Eight to 15 Years

Introduction Autism spectrum disorder (ASD) is a neurological and developmental disorder, which poses challenges to social communication and behavior, particularly affecting social functioning. Individuals with ASD face significant social challenges, including difficulty understanding social cues and body language, limited ability to engage in reciprocal social interactions, and challenges with establishing empathy. A preference for routines and repetitive behaviors limits their ability to adapt to new or unexpected social situations. These problems tend to escalate during adolescence. These often cause distress to the individual as well as the caregivers. Group-based social skills interventions (GSSIs) are a widely used and effective modality for addressing core social impairments in children with autism. This study aims to assess the impact of GSSI on the broad age group of eight to 15 years, involving parents to enhance the transferability of children's social skills. Methods This was a single-arm interventional study where 30 verbal autistic children, aged eight to 15 years, with intelligence quotient (IQ) > 70 were enrolled after utilizing the Binet Kamat Test of Intelligence (BKT) to assess IQ and the Indian Scale for Assessment of Autism (ISAA) to grade severity of autism. The children received GSSI from interdisciplinary therapists for 12 sessions, on a weekly basis, lasting 90 minutes each for a period of three months. After each therapy session, parents received summaries of each session and were delegated reinforcing homework assignments to enable generalization and maintenance of the skills taught. Outcome measures were taken at three points in time by utilizing the Social Communication Questionnaire (SCQ) and the parent-rated Social Responsiveness Scale 2 (p-SRS-2): T1: pre-therapy at the time of enrolment; T2: immediately post-therapy at the end of three months of training; and T3: long-term follow-up, three months after the end of training. Results Mean SCQ scores were as follows: T1 = 21.87, T2 = 18.57, and T3 = 18.57 (p = 0.000). This progressive decline at T1, T2, and T3 indicated a decreasing trend in the severity of difficulties in the social communication domain. Mean p-SRS-2 scores were as follows: T1 = 73.00, T2 = 64.57, and T3 = 64.30 (p < 0.0001). This declining trend at T1, T2, and T3 suggested a statistically significant decrease in the severity of difficulties faced in various social aspects tested by the p-SRS-2, i.e., social awareness, social cognition, social communication, and social motivation, along with a reduction in restricted interests and repetitive behaviors (RRBs). Very strong correlation coefficients were obtained for SCQ scores (T1-T2 = 0.921, T1-T3 = 0.921, and T2-T3 = 1.000), as well as for p-SRS-2 scores (T1-T2 = 0.743, T1-T3 = 0.746, and T2-T3 = 0.989), which reinforced the statistical significance of the data. Conclusion GSSI is an effective parent-assisted intervention for adolescents with ASD, with effects lasting up to three months post-intervention.
Effect of Prenatal Iron Supplementation Adapted to Hemoglobin Levels in Early Pregnancy on Fetal and Neonatal Growth—ECLIPSES Study

In this randomized clinical trial, we evaluated the effects of prenatal iron supplementation adapted to pregnant women’s initial hemoglobin (Hb) levels on fetal growth parameters until birth in women from the Mediterranean coast of northern Spain. All (n = 791) women were iron-supplemented during pregnancy according to Hb levels at the 12th gestational week: stratum 1 (Hb: 110–130 g/L) received 40 or 80 mg iron daily; stratum 2 (Hb > 130 g/L) received 40 or 20 mg iron daily. Fetal biometric and anthropometric measurements were evaluated in the three trimesters and at birth, respectively. In stratum 1, using 80 mg/d instead of 40 mg/d increased the risk of fetal head circumference > 90th percentile (OR = 2.49, p = 0.015) at the second trimester and fetal weight (OR = 2.36, p = 0.011) and femur length (OR = 2.50, p = 0.018) < 10th percentile at the third trimester. For stratum 2, using 40 mg/d instead of 20 mg/d increased the risk of fetal head circumference > 90th percentile (OR = 3.19, p = 0.039) at the third trimester. A higher risk of delivering an LGA baby (OR = 2.35, p = 0.015) for birthweight was also observed in stratum 1 women receiving 80 mg/d. It is crucial to adjust the prenatal iron supplementation to each pregnant woman’s needs, i.e., adapted to their initial Hb levels, to achieve optimal fetal development, since excessive iron doses appear to adversely influence fetal growth.
A protocol for systematic review and meta-analysis

Background: Sepsis has become a global healthcare problem and continues to be one of the leading causes of death due to infection. In essence, early recognition and diagnosis of sepsis is needed to inhibit the transition into septic shock, which is correlated with higher mortality. Many studies have suggested antimicrobial de-escalation as one of the strategies to replace the empirical broad-spectrum antimicrobial treatment using a narrower antimicrobial therapy, especially among patients with sepsis. However, antimicrobial de-escalation therapeutic effects in sepsis remains unclear. We therefore performed the present study in an attempt to assess efficacy and safety of antimicrobial de-escalation therapy in patients with sepsis. Methods: We will carry out a systematic literature search to establish the potentially eligible trials from electronic databases, including EMBASE (1980 toOctober 16, 2020), MEDLINE via PubMed (1966 toOctober 16, 2020),Web of Science (1965 to October 16, 2020), Cochrane Library (CENTRAL; 2020, Issue 10), WanFang databases (last searched October 16, 2020), and China National Knowledge Infrastructure (CNKI; last searched October 16, 2020). For this study, the language restrictions are English or Chinese. Two authors independently examined quality based on the Cochrane Risk of Bias Tool V.2. 0 and extracted data. Data obtained from the study will be synthesised using applicable statistical methods. Results:The results of the present study will systematically assess efficacy and safety of antimicrobial de-escalation therapy among patients with sepsis. Conclusion: The results of the present study will help to establish the efficacy and safety of antimicrobial de-escalation to treat patients with sepsis. It can also help to identify the most efficient and safe therapeutically-relevant method. Ethics and dissemination: The present study is a meta-analysis and the pooled results are based on published evidence. Therefore, ethics approval is not necessary. OSF registration number: October 22, 2020.osf.io/93wym. (https://osf.io/93wym/). Abbreviations: XX = XX.
A CAUSAL GENE NETWORK WITH GENETIC VARIATIONS INCORPORATING BIOLOGICAL KNOWLEDGE AND LATENT VARIABLES

A Bayesian network has often been modeled to infer a gene regulatory network from expression data. Genotypes along with gene expression can further reveal the regulatory relations and genetic architectures. Biological knowledge can also be incorporated to improve the reconstruction of a gene network. We propose a Bayesian framework to jointly infer a gene network and weights of prior knowledge by integrating expression data, genetic variations, and prior biological knowledge. The proposed method encodes biological knowledge such as transcription factor and DNA binding, gene ontology annotation, and protein-protein interaction into a prior distribution of the network structures. A simulation study shows that the incorporation of genetic variation information and biological knowledge improves the reconstruction of gene network as long as biological knowledge is consistent with expression data. There are some assumptions that the Bayesian network inference is making. One assumption is that all variables are included, in other words, there are no latent variables. An ancestral graph properly represents the conditional independence relations on observed variables when there are latent variables in an underlying Bayesian network. Without needing to introduce latent variables, we modeled a set of recursive equations for an ancestral graph of phenotypes extended with genetic variations. We showed that 1) its parametric family is a homogeneous conditional Gaussian (HCG) family and 2) the extended graph satisfies the ancestral graph conditions.
Rutin Linoleate Triggers Oxidative Stress-Mediated Cytoplasmic Vacuolation in Non-Small Cell Lung Cancer Cells

Lung cancer (LC) represents one of the most prevalent health issues globally and is a leading cause of tumor-related mortality. Despite being one the most attractive compounds of plant origin due to its numerous biological properties, the therapeutic applications of rutin (RUT) are limited by its disadvantageous pharmacokinetics. Thus, the present study aimed to evaluate in vitro the application of two RUT fatty acids bioconjugates, rutin oleate (RUT-O) and rutin linoleate (RUT-L), as potential improved RUT-based chemotherapeutics in non-small cell lung cancer (NSCLC) treatment. The results indicate that both compounds lacked cytotoxic potential in EpiAirway™ tissues at concentrations up to 125 µM. However, only RUT-L exerted anti-tumorigenic activity in NCI-H23 NSCLC cells after 24 h of treatment by reducing cell viability (up to 47%), proliferation, and neutral red uptake, causing cell membrane damage and lactate dehydrogenase (LDH) leakage, affecting cytoskeletal distribution, inducing cytoplasmic vacuolation, and increasing oxidative stress. The cytopathic effects triggered by RUT-L at 100 and 125 µM are indicators of a non-apoptotic cell death pathway that resembles the characteristics of paraptosis. The novel findings of this study stand as a basis for further investigations on the anti-cancer properties of RUT-L and their underlying mechanisms.
An improved TLD with Harris corner and color moment

Video tracking is a main field of computer vision, and TLD algorithm plays a key role in long-term tracking. However, the original TLD ignores the color features of patch in detection, and tracks the common points from grid, then, the tracking accuracy is limited to both of them. This paper presents a novel TLD algorithm with Harris corner and color moment to overcome this drawback. Instead of tracking common points, we screen more important points utilizing Harris corner to reject a half patches, these points are better able to show the object’s textural features. In addition, the color moment classifier replaces patch variance to reduce the errors of detection. The classifier compares mine-dimensional color moment vectors so that it can keep the TLD’s stable speed. Experiment has proved that our TLD tracks a more reliable position and higher ability without affecting the speed.
A New Scaphognathine Pterosaur from the Middle Jurassic of Western Liaoning,China

A new scaphognathine pterosaur:Fenghuangopterus lii gen.et sp.nov.is erected based on an incomplete skeleton.It comes from the Middle Jurassic Tiaojishan Formation of the western Liaoning.It is characterized by more than 11 pairs of the upper jaw teeth,and the last tooth is located far posteriorly in the jaw,under the postoventral corner of the antorbital opening,metacarpal IV length is about 55% that of the humerus.The discovery of Fenghuangopterus not only adds a new member of scaphognathine pterosaurs,but also provides much more information on the paleogeographical distribution.It represents the earliest scaphognathine pterosaur known.It plays a key role in understanding the origin and evolution of scaphognathine pterosaurs.
Glycerol-derived organic carbonates: environmentally friendly plasticizers for PLA

Polylactic acid (PLA) stands as a promising material, sourced from renewables and exhibiting biodegradability—albeit under stringent industrial composting settings. A primary challenge impeding PLA's broad applications is its inherent brittleness, as it fractures with minimal elongation despite its commendable tensile strength. A well-established remedy involves blending PLA with plasticizers. In this study, a range of organic carbonates—namely, 4-ethoxycarbonyloximethyl-[1,3]dioxolan-2-one (1), 4-methoxycarbonyloximethyl-[1,3]dioxolan-2-one (2), glycerol carbonate (3), and glycerol 1-acetate 2,3-carbonate (4)—were synthesized on a preparative scale (∼100 g), using renewable glycerol and CO2-derived diethyl carbonate (DEC) or dimethyl carbonate (DMC). Significantly, 1–4 exhibited biodegradability under ambient conditions within a week, ascertained through soil exposure at 25 °C—outpacing the degradation of comparative cellulose. Further investigations revealed 1's efficacy as a PLA plasticizer. Compatibility with PLA, up to 30 phr (parts per hundred resin), was verified using an array of techniques, including DSC, DMA, SEM, and rotational rheometry. The resulting blends showcased enhanced ductility, evident from tensile property measurements. Notably, the novel plasticizer 1 displayed an advantage over conventional acetyltributylcitrate (ATBC) in terms of morphological stability. Slow crystallization, observed in PLA/ATBC blends over time at room temperature, was absent in PLA/1 blends, preserving amorphous domain dimensions and mitigating plasticizer migration—confirmed through DMA assessments of aged and unaged specimens. Nevertheless, biodegradation assessments of the blends revealed that the biodegradable organic carbonate plasticizers did not augment PLA's biodegradation. The PLA in the blends remained mostly unchanged under ambient soil conditions of 25 °C over a 6 month period. This work underscores the potential of organic carbonates as both eco-friendly plasticizers for PLA and as biodegradable compounds, contributing to the development of environmentally conscious polymer systems.