Miracle-dz/UniFAR-FTUs huggingface dataset:
Sexual Function of Patients with Deep Endometriosis after Surgical Treatment: A Systematic Review

Abstract Objective To review the current state of knowledge on the impact of the surgical treatment on the sexual function and dyspareunia of deep endometriosis patients. Data Source A systematic review was conducted in accordance with the Meta-Analysis of Observational Studies in Epidemiology (MOOSE) guidelines. We conducted systematic searches in the PubMed, EMBASE, LILACS, and Web of Science databases from inception until December 2022. The eligibility criteria were studies including: preoperative and postoperative comparative analyses; patients with a diagnosis of deep endometriosis; and questionnaires to measure sexual quality of life. Study Selection Two reviewers screened and reviewed 1,100 full-text articles to analyze sexual function after the surgical treatment for deep endometriosis. The risk of bias was assessed using the Newcastle-Ottawa scale for observational studies and the Cochrane Collaboration's tool for randomized controlled trials. The present study was registered at the International Prospective Register of Systematic Reviews (PROSPERO; registration CRD42021289742). Data Collection General variables about the studies, the surgical technique, complementary treatments, and questionnaires were inserted in an Microsoft Excel 2010 (Microsoft Corp., Redmond, WA, United States) spreadsheet. Synthesis of Data We included 20 studies in which the videolaparoscopy technique was used for the excision of deep infiltrating endometriosis. A meta-analysis could not be performed due to the substantial heterogeneity among the studies. Classes III and IV of the revised American Fertility Society classification were predominant and multiple surgical techniques for the treatment of endometriosis were performed. Standardized and validated questionnaires were applied to evaluate sexual function. Conclusion Laparoscopic surgery is a complex procedure that involves multiple organs, and it has been proved to be effective in improving sexual function and dyspareunia in women with deep infiltrating endometriosis.
Integrated Water Resources Management: A Comparative Laboratory for Water Governance

In this article the special issue on Integrated Water Resources Management is introduced. This special issue aims to add substantially to comparative cross-country knowledge building. The paper builds upon the insights gained from the various contributions to this special issue, coming from 13 different countries spread across the globe. The concept of IWRM is discussed from the angles of the Rio-Dublin principles, Global Water Partnership definition and concepts and ideas from adaptive governance. Furthermore, integration is discussed as the core of IWRM: functional, societal and institutional integration. Based on the insight gained from the range of contributions from this special issue, we argue that IWRM needs more systematic and comparative approaches from both administrative (de)centralization and economic development points of view. Moreover, in our comparative study we found trade-offs between the three identified forms of integration. We argue that a perspective of an adaptive walk is required that tries to gain more understanding in specific decentralization-centralization configurations per case/country/region leading to (misfits in) functional, societal and institutional integration regarding IWRM. Keywords: integrated water resources management, functional, societal and institutional integration, adaptive governance, (de)centralization, economic development.
Long‐term evolution of the structure of the St. Lawrence (Canada) marine ecosystem in the context of climate change and anthropogenic activities: An isotopic perceptive

Abstract Documenting long‐term changes in the trophic structure of food webs and how species respond to these changes is essential to forecast their vulnerability and resilience to environmental stressors. Over the past decades, the St. Lawrence marine ecosystem (Canada) has experienced major changes in its physical, chemical, and biological conditions from overfishing, acoustic and chemical pollution, climate change, and the increased abundance of some top predators. These changes have likely affected the trophodynamics of the ecosystem, and are suspected to have deleterious effects on endangered species of mammals and other components of the ecosystem, such as blue whales (Balaenoptera musculus), fin whales (B. physalus), and beluga (Delphinapterus leucas). This study examined the trophic structure of the St. Lawrence marine ecosystem, including the isotopic niche of various species, over two periods of contrasting pressures from anthropogenic and climatic stressors (1995–2003 vs. 2019–2021). Stable isotope ratios were measured in 1240 samples of 21 species of marine invertebrates, fishes, and mammals sampled during both periods. A significant change in the isotopic value and niche position between periods is observed in most of the sampled species. While the direction of change and effect size were not uniform among species, these changes confirmed that substantial modifications in community structure have occurred over time. Niche overlap decreased considerably among some of the pelagic and demersal fishes, and among whale species during the most recent period. Combined with a concomitant reduction in niche breadth in several species, these observations suggested that resource sharing was limited among these species. This study highlighted some degree of dietary plasticity in several species, and a long‐term change in the trophic structure of the St. Lawrence marine ecosystem, with likely effects on diet composition and energetics of several populations, including endangered species.
Aggressive systemic mastocytosis with multiple organ involvement: a case report

Abstract Systemic mastocytosis is a rare malignancy whose main diagnostic finding is the abnormal proliferation of clonal mast cells. In this report, a 63-year-old woman is presented who was referred to the emergency department with lower back pain. Due to the hypereosinophilia in blood tests, a bone marrow biopsy was performed, and except for the presence of a large number of mastocytes, no other pathologic findings were seen. Furthermore, the immunohistochemistry test showed positive CD117 and CD25 markers, and the patient’s platelet-derived growth factor receptor alpha test was positive. Hence, the patient was diagnosed with aggressive systemic mastocytosis. Treatment was initiated with the Cladribine regimen, but unfortunately, in the third course, the patient experienced bradycardia and loss of consciousness and expired. Systemic mastocytosis can manifest itself with non-cutaneous symptoms. Non-cutaneous symptoms do not rule out systemic mastocytosis as a differential diagnosis in patients with hypereosinophilia.
The effect of sodium-glucose cotransporter 2 inhibitors in patients with chronic kidney disease with or without type 2 diabetes mellitus on cardiovascular and renal outcomes: A systematic review and meta-analysis

Background Sodium-glucose cotransporter 2 (SGLT-2) inhibitors have shown a favorable effect on cardiovascular and renal outcomes in patients with type 2 diabetes mellitus (T2DM). However, their efficacy in patients with chronic kidney disease (CKD) with or without T2DM has not yet been analyzed. Objective To assess the cardiovascular and renal effects of SGLT-2 inhibitors in patients with CKD with and without T2DM, including all CKD patients in the current literature. Methods We searched MEDLINE, EMBASE, CENTRAL and Scopus for randomized controlled trials of SGLT-2 inhibitors that evaluated cardiovascular and kidney outcomes in patients with CKD, or trials in which these patients were a subgroup. We defined 2 primary outcomes: a composite of cardiovascular death or hospitalization for heart failure, and a composite renal outcome. For each outcome, we obtained overall hazard ratios with 95% confidence intervals by using a random effects model. Results We included 14 randomized controlled trials. SGLT-2 inhibitors decreased the hazard for the primary cardiovascular outcome (HR 0.76; [95% CI 0.72–0.79]) and the primary renal outcome (HR 0.69; [95% CI 0.61–0.79]) in patients with CKD with or without T2DM. We did not find significant differences in the subgroup analyses according to diabetes status, baseline eGFR values or the type of SGLT-2 inhibitor used. Conclusion In patients with CKD, treatment with SGLT-2 inhibitors in addition to standard therapy conferred protection against cardiovascular and renal outcomes. Further research on patients with non-diabetic CKD should be done to confirm the utility of these medications in this population. (PROSPERO ID: CRD42021275012).
Combining finite element and reinforcement learning methods to design superconducting coils of saturated iron-core superconducting fault current limiter in the DC power system

A saturated iron-core type superconducting fault current limiter (SI-SFCL) can effectively restrict the magnitude of the fault current and alleviate the strain on circuit breakers in DC power systems. Design of a superconducting coil (SC), which is one of the key tasks in the SI-SFCL design, requires guaranteeing a sufficient magnetic field, ensuring optimization of the shape and size, minimizing the wire cost, and satisfying the safety and stability of operation. Generally, finite element method (FEM) is used to calculate and evaluate the operating characteristics of SCs, from which it is possible to determine their optimal design parameters. When the coil is complex and large, the simulation time may range from hours to days, and if input parameters change even slightly, the simulations have to be redone from scratch. Recent advances in deep learning represent the ability to be effective for modeling and optimizing complex problems from training data or in real-time. In this paper, we presented a combination of the FEM simulation and deep Q-network (DQN) algorithm to optimize the SC design of a lab-scale SI-SFCL for a DC power system. The detailed design process and options for the SC of SI-SFCL were proposed. In order to analyze the characteristics related to the electromagnetic properties and operational features of the SC, a 3D FEM model was developed. Then, a DQN model was constructed and integrated with the FEM simulation for training and optimizing the design parameters of the SC in real-time. The obtained results of this study have the potential to effectively optimize the design parameters of large-scale SI-SFCL development for high-voltage DC power systems.
The oldest fossil bird-like footprints from the upper Triassic of southern Africa

Footprint morphology reflects the anatomy of the trackmaker’s foot and is direct evidence for the animal’s behaviour. Consequently, fossil tracks can be used to infer ancient diversity, ethology, and evolutionary trends. This is particularly useful for deep-time intervals during which the early history of an animal group is reliant upon limited fossil skeletal material. Fossil tracks of early birds and theropods, the co-existing dinosaurian ancestors of birds, co-occur in the rock record since the Early Cretaceous. However, the evolutionary transition from dinosaur to bird and the timing of the birds’ origin are still contested. Skeletal remains of the basal-most birds Aurornis, Anchiornis, Archaeopteryx and Xiaotingia are Middle to Late Jurassic, while tracks with tentative bird affinities, attributed to dinosaurs, are known from as early as the Late Triassic. Here, we present numerous, well-provenanced, Late Triassic and Early Jurassic tridactyl tracks from southern Africa, with demonstrable bird-like affinities, predating basal bird body fossils by c. 60 million years.
The telomere resolvase, TelA, utilizes an underwound pre-cleavage intermediate to promote hairpin telomere formation

The telomere resolvase, TelA, forms the hairpin telomeres of the linear chromosome of Agrobacterium tumefaciens in a process referred to as telomere resolution. Telomere resolution is a unique DNA cleavage and rejoining reaction that resolves replicated telomere junctions into a pair of hairpin telomeres. Telomere resolvases utilize a reaction mechanism with similarities to that of topoisomerase-IB enzymes and tyrosine recombinases. The reaction proceeds without the need for high-energy cofactors due to the use of a covalent, enzyme-cleaved DNA intermediate that stores the bond energy of the cleaved bonds in 3’-phosphotyrosyl linkages. The cleaved DNA strands are then refolded into a hairpin conformation and the 5’-OH ends of the refolded strands attack the 3’-phosphotyrosine linkages in order to rejoin the DNA strands into hairpin telomeres. Because this kind of reaction mechanism is, in principle, reversible it is unclear how TelA controls the direction of the reaction and propels the reaction to completion. We present evidence that TelA forms and/or stabilizes a pre-cleavage intermediate that features breakage of the four central basepairs between the scissile phosphates prior to DNA cleavage to help propel the reaction forwards, thus preventing abortive cleavage and rejoining cycles that regenerate the substrate DNA. We identify eight TelA sidechains, located in the hairpin-binding module and catalytic domains of TelA, implicated in this process. These mutants were deficient for telomere resolution on parental replicated telomere junctions but were rescued by introduction of substrate modifications that mimic unwinding of the DNA between the scissile phosphates.
Health professionals’ knowledge on vaccine cold chain management and associated factors in Ethiopia: Systematic review and meta-analysis

Background Vaccines are playing a great role in prevention of many infectious diseases worldwide. Health professionals’ knowledge towards vaccine cold chain management is an essential element of maintaining vaccine’s potency at shelf and during transportation. Studies on health professionals’ knowledge on vaccine cold chain management system and associated factors in Ethiopia have inconclusive findings. This systematic review and meta-analysis is aimed to produce the overall level of health professionals’ knowledge on vaccine cold chain management system and to identify its associated factors in Ethiopia. Methods Systematic review and meta-analysis was conducted on health professionals’ knowledge on vaccine cold chain management in Ethiopia. It is registered under PROSPERO website with registration number CRD42023391627. Literature search was made on international data bases using medical subject heading and key words. Data were extracted using Microsoft excel and imported to STATA version 17 for analysis. Heterogeneity was checked using Cochrane Q test and I2 statistics. Weighted Inverse variance random effect model was used to estimate the pooled level of health professionals’ knowledge on vaccine cold chain management. Publication bias was checked using funnel plot and using Egger’s test. Results A total of nine studies were included in the review. The pooled health professionals’ good knowledge on vaccine cold chain management in Ethiopia is 49.92% with 95% CI (48.06–51.79). Having five years or more experience AOR 2.27 95% CI (1.72–2.99), being nurse AOR 3.03 95% CI (1.47–6.27), received on job training AOR 6.64 95% CI (4.60–9.57), EPI guideline available at facility AOR 2.46 95% CI (1.75.-3.48) are factors positively associated with health professionals’ knowledge on vaccine cold chain management in Ethiopia. Conclusion The pooled prevalence of good knowledge on vaccine cold chain management among health professionals is much lower than the expected level. There is a need to plan on job trainings for all vaccine handlers and other health professionals supposed to work on vaccination program.
Prevalence and molecular basis of null blood group phenotypes in the Korean population: Analysis using a public database

Null phenotypes are characterized by complete absence of all antigens within a blood group system and caused by null variants (e.g., nonsense, frameshift, initiation codon, and canonical splice site variants) in the genes encoding the antigens. Knowing the prevalence and molecular basis of null phenotypes is essential to establish a rare donor program, and the aim of this study was to reveal the prevalence and molecular basis of null phenotypes using the Korean Reference Genome Database (KRGDB) containing whole‐genome sequences of 1722 Korean individuals.
Developmental fluoxetine exposure affects adolescent and adult bone depending on the dose and period of exposure in mice

At the end of gestation, fetal skeleton rapidly accumulates calcium, and bone development continues in offspring postnatally. To accommodate, maternal skeletal physiology is modulated in a serotonin‐dependent manner. Selective serotonin reuptake inhibitors (SSRIs) are generally considered safe for treatment of major depressive disorder, postpartum depression, and other psychiatric illnesses during the peripartum period, but because serotonin affects bone remodeling, SSRIs are associated with decreased bone mass across all ages and sexes, and the impact of SSRIs during fetal and postnatal development has not been fully investigated. In the present study, our aim was to examine developmental fluoxetine exposure on offspring skeleton and to assess varying degrees of impact depending on dose and window of exposure in short‐term and long‐term contexts. We established that a low dose of lactational fluoxetine exposure caused a greater degree of insult to offspring bone than either a low dose during fetal and postpartum development or a high dose during lactation only in mice. We further discovered lasting impacts of developmental fluoxetine exposure, especially during lactation only, on adult bone and body composition. Herein, we provide evidence fluoxetine exposure during early development may have detrimental effects on the skeleton of offspring at weaning and into adulthood.
Self-report or coach-rating? The predictive validity of different approaches to assess athletes’ achievement motivation in team and individual sports

ABSTRACT The critical role of psychological features in talent identification research is well established. What remains open is how they should be captured, as self-report as well as coach-rating approaches can be subject to bias when used for talent selection purposes (e.g., social desirability and halo effect). The purpose of this study was to examine which of three different approaches (self-report, coach-rating, and a combination of both) to assess constructs related to achievement motivation offers the highest validity for predicting performance levels of youth athletes in individual and team sports over a two-year period using binary logistic regression models and the DeLong test. Descriptively, the combination model displayed the highest predictive validity, followed by coach-ratings and self-reports. However, only the comparison of the combination and self-report models displayed meaningful differences. The findings do not allow a definitive conclusion, but coach-ratings might be the least biased and most cost and time effective approach.
Rollability, a functional shape property of sand grains

ABSTRACT The development of a new method to measure a behavioral shape property of sand grains is presented. This property "rollability" is related to the angle of slope on which a grain will roll down in air. It is measured on the inside of a slightly inclined revolving cylinder mantle. The grains emerge from the lower end of the cylinder and the time it takes them to reach this lower end is a measure for their rollability. The property "rollability" correlates well with the influence of grain shape in other processes such as settling in water. The rollability is measured on phi sieve fractions. The measurements are transferred to relative rollability values. For a certain area, the mean of all the rollability values is calculated per sieve fraction and the individual measurements are expressed as percentile deviations of this mean value. In this way, the strong influence of the source of the material on the shape characteristics is largely excluded and the observed shape differences between samples can be attributed exclusively to shape sorting phenomena. This facilitates the comparison between sediments of same depositional circumstances but different s urce. Per sample, graphs are plotted which show the distribution of the relative rollability values over the size fractions. This property is called the Shape Distribution Character (S.D.C.). It appears to be characteristic for the mode of origin. Shape selection phenomena are best understood in connection with Kuenen's deposit-repository concept. When a population is split by a transport mechanism into two (or more) different populations, these populations have complementary characteristics as regards size, shape and density. Such a twin relationship comes out very clearly in the S.D.C.'s of the deposit and its repository. Examples are shown of such genetic relationships in the complementary character of the shallow off-shore zone with the beach, the beach and adjoining dunes, and the eolian cover sands with the areas from which the sands have been blown out.
Metasurface-based Optical Logic Operators Driven by Diffractive Neural Networks.

In this paper, a novel optical logic operator based on the multifunctional metasurface driven by all-optical diffractive neural network is reported, which can perform four principal quantum logic operations (Pauli-X, Pauli-Y, Pauli-Z and Hadamard gates). The two ground states |0〉 and |1〉 are characterized by two orthogonal linear polarization states. The proposed spatial- and polarization-multiplexed all-optical diffractive neural network only contains a hidden layer physically mapped as a metasurface with simple and compact unit cells, which dramatically reduces the volume and computing resources required for the system. The designed optical quantum operator has been proven to achieve high fidelities for all four quantum logical gates, up to 99.96% numerically and 99.88% experimentally. Our solution would facilitate the construction of large-scale optical quantum computing systems and scalable optical quantum devices. This article is protected by copyright. All rights reserved.
Histone Modifications and Their Contributions to Hypertension

Essential hypertension, a multifaceted disorder, is a worldwide health problem. A complex network of genetic, epigenetic, physiological, and environmental components regulates blood pressure (BP), and any dysregulation of this network may result in hypertension. Growing evidence suggests a role for epigenetic factors in BP regulation. Any alterations in the expression or functions of these epigenetic regulators may dysregulate various determinants of BP, thereby promoting the development of hypertension. Histone posttranslational modifications are critical epigenetic regulators that have been implicated in hypertension. Several studies have demonstrated a clear association between the increased expression of some histone-modifying enzymes, especially HDACs (histone deacetylases), and hypertension. In addition, treatment with HDAC inhibitors lowers BP in hypertensive animal models, providing an excellent opportunity to design new drugs to treat hypertension. In this review, we discuss the potential contribution of different histone modifications to the regulation of BP.