Miracle-dz/UniFAR-FTUs huggingface dataset:
Relationship between antipsychotic medication treatment and new cases of diabetes among psychiatric inpatients.

OBJECTIVE This study examined data on patients with serious and persistent mental illness in a large state hospital system to determine whether patients who took second-generation antipsychotics were more likely to develop diabetes mellitus than patients who took first-generation antipsychotics. METHODS A case-control study design was used. A new prescription of an antidiabetic medication was used to identify new cases of diabetes mellitus. Odds ratios were calculated for exposure to second-generation antipsychotics (clozapine, risperidone, olanzapine, quetiapine, and multiple second-generation antipsychotics) compared with exposure to first-generation antipsychotics. Cases and controls were identified by using a database that contained drug prescription information from the inpatient facilities that were operated by the New York State Office of Mental Health. Data from January 1, 2000, to December 31, 2002, were examined. Among 13,611 unique patients who received antipsychotics, 8,461 met entry criteria of being hospitalized for at least 60 days and not having an antidiabetic medication prescribed in the past. A total of 181 of these inpatients received prescriptions for an antidiabetic medication at least 30 days after their admission. Eight controls (N=1,448) for each case (N=181) were matched by calendar year, length of observation period, race, age group, and diagnosis, giving a total sample of 1,629 patients. RESULTS Statistically significant elevations in risk were seen among patients who received more than one second-generation antipsychotic or clozapine or quetiapine, compared with patients who received first-generation antipsychotics alone. Although not statistically significant, odds ratios for olanzapine and risperidone were also elevated. Conditional logistic regression adjusting for gender and age did not change the results. CONCLUSIONS Exposure to multiple second-generation antipsychotics or clozapine or quetiapine significantly increased the risk of treatment-emergent diabetes mellitus.
Gingival fibroblasts grown from cyclosporin-treated patients show a reduced production of matrix metalloproteinase-1 (MMP-1) compared with normal gingival fibroblasts, and cyclosporin down-regulates the production of MMP-1 stimulated by pro-inflammatory cytokines.

BACKGROUND AND OBJECTIVE Cyclosporin-induced gingival overgrowth arises from an alteration in collagen homeostasis and is enhanced by inflammatory changes in the gingival tissues. The aim of this study was to investigate the interaction among interleukin-1, oncostatin M, cyclosporin and nifedipine in promoting the up-regulation of matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase by gingival fibroblasts. MATERIAL AND METHODS Fibroblast cultures (n = 5) were obtained from healthy controls and from patients with cyclosporin-induced gingival overgrowth, and cells were harvested between the fourth and ninth passages. Cells were stimulated with interleukin-1 and oncostatin M, alone or in combination, and with different concentrations of cyclosporin (0-2000 ng/mL) and nifedipine (0-200 ng/mL). MMP-1 and tissue inhibitor of metalloproteinase-1 production was determined using an enzyme-linked immunosorbent assay technique. A CyQuant cell proliferation assay was used to determine the DNA concentration in the sample. RESULTS Fibroblasts obtained from patients with cyclosporin-induced gingival overgrowth produced significantly lower levels of MMP-1 than control fibroblasts (p < 0.001); tissue inhibitor of metalloproteinase-1 levels were significantly lower (p < 0.05), and the ratio of MMP-1 to tissue inhibitor of metalloproteinase-1 was reduced, in the conditioned medium of patients with cyclosporin-induced gingival overgrowth compared with controls. Interleukin-1 and oncostatin M produced a significant increase in the up-regulation of MMP-1, which was reversed when cyclosporin and nifedipine were added to the cell cultures (p < 0.05). CONCLUSION Pro-inflammatory cytokines significantly up-regulate MMP-1 in cultured gingival fibroblasts. Up-regulation is attenuated by both cyclosporin and nifedipine. The interaction may account for the synergism between inflammation and cyclosporin-induced gingival overgrowth.
EEG Coherence Analysis in Never-Medicated Patients with Panic Disorder

To investigate the functional abnormalities in the central nervous system (CNS) of patients with panic disorder (PD), we compared the electroencephalography (EEG) coherence values in 18 never-medicated PD patients with those in age-matched normal control subjects, and examined the relationships between EEG coherence values and both the duration of disease and the severity of panic attacks. EEG data were recorded in the resting state. The PD patients had lower coherence values with significant differences in F3–F4, C3–C4, P3–P4, F7–T5, and F8–T6. There were positive correlations for the higher alpha band between coherence values and both the duration of disease and the severity of panic attacks. These findings provide further evidence that PD patients have a lower degree of inter-hemispheric functional connectivity in the frontal region and intra-hemispheric functional connectivity in the bilateral temporal region, and that chronic condition or frequent panic attacks in PD patients may be related to the pathophysiological CNS changes.
BiCMOS microfluidic sensor for single cell label-free monitoring through microwave intermodulation

A novel microfluidic biosensing platform based on Bipolar-Complementary Oxide Semiconductor (BiCMOS) technology is presented. The device relies on a quadruple electrode system and a microfluidic channel that are directly integrated into the back-end-of-line (BEOL) of the BiCMOS stack. For proof of concept repeatable electrical trapping of single SW620 (colon cancer) cells in the quadruple electrode system is initially demonstrated. Additionally, for the first time a microwave intermodulation technique is used for high sensitivity dielectric spectroscopy, which could pave the way to label-free monitoring of intracellular processes and manipulation such as electroporation.
The natural history of acute histologic rejection without biochemical graft dysfunction in orthotopic liver transplantation: A systematic review

Protocol biopsy results in the first few weeks after liver transplantation sometimes display histologic features of acute cellular rejection (ACR), even in the absence of significant clinical or biochemical dysfunction. At present there is no clear consensus about the need to treat such cases with adjuvant immunosuppression. This systematic review describes, from the available evidence, the natural history of untreated histologic ACR in the absence of biochemical graft dysfunction. An electronic search of the Medline, Embase, and Cochrane Library databases was performed to select studies that reported protocol liver biopsies in the early posttransplant period from 1983 to 2000. Studies that identified patients with ACR on protocol biopsy who were not treated with adjuvant immunosuppression formed the basis of the study group. Data from individual studies were extracted using standardized pro forma and pooled for descriptive analysis. The search identified 3431 studies, of which 516 were cited in full. Of these, 15 studies met all of the inclusion criteria. These 15 studies reported on 1566 patients who had protocol biopsies performed in the early posttransplant period, of which 1048 (67%) had histologic evidence of ACR. Three hundred and thirty one (32%) patients with histologic ACR on protocol biopsy had no associated biochemical graft dysfunction. Without treatment, only 14% of these patients subsequently developed biochemical graft dysfunction requiring adjuvant immunosuppression. Steroid‐resistant rejection and chronic rejection both had a prevalence of 4% in patients with untreated histologic ACR and no biochemical graft dysfunction. Withholding adjuvant immunosuppression from patients with histologic ACR and no biochemical graft dysfunction seems to be safe, as long as graft function is carefully monitored. The rationale for performing protocol biopsies in the absence of biochemical graft dysfunction is questionable.
A dynamic model of proliferation and differentiation in the intestinal crypt based on a hypothetical intraepithelial growth factor

A widely accepted model of the temporal and spatial organization of proliferation and differentiation in intestinal epithelia is based on a cellular pedigree with all cells descending from a few active stem cells and undergoing a sequence of transitory divisions until the non‐proliferating maturing cell stages develop. Model simulations have shown that such a pedigree concept can explain a large variety of data. However, so far there is neither a direct experimental proof for the existence of an intrinsic age structure in the transitory proliferative cell stages nor for the distinction between stem and transitory cells. It is our objective to suggest an alternative model which is based on evidence for intercellular communications such as might be mediated through gap junctions. We consider the diffusion of a hypothetical intraepithelial growth factor in a chain of cells which are connected via gap junctions. Individual cells can divide if a critical growth factor concentration is exceeded. Simulation studies show that the model is consistent with many observed features of the small intestinal crypt in steady state and after perturbation.
Obstáculos al desarrollo del sistema financiero en México

This article briefly examines the recent evolution of the Mexican financial system. Based on this, obstacles are identified. It is argued that two are most important. First, the property rights protection is weak in Mexico, thus it inhibits credit expansion. Second, competition is low and it is of most importance to expand the analysis to the financial system as a whole.
Myostatin expression in porcine tissues: tissue specificity and developmental and postnatal regulation.

The objective of this study was to establish the developmental pattern and tissue specificity of porcine myostatin expression and to evaluate expression in skeletal muscle during circumstances in which muscle growth was altered. Northern blot analysis revealed two transcripts (1.5 and 0.8 kb). Myostatin mRNA was detected in whole fetuses at 21 and 35 days and was markedly increased (P < 0.05) by 49 days. At birth, mRNA abundance in longissimus muscle had declined significantly (P < 0.05) from that at day 105 of gestation and continued to decrease (P < 0.05) to its lowest level 2 wk postnatally (4 kg body wt). Myostatin expression was higher (P < 0. 05) at 55, 107, and 162 kg body wt than at 4 kg body wt. Postnatally, myostatin mRNA was detected in skeletal muscle and mammary gland. Expression at birth was 65% higher (P < 0.04) in longissimus muscle of low-birth-weight piglets (0.57 +/- 0.052 kg body wt) vs. normal (1.37 +/- 0.077 kg body wt) littermates, irrespective of gender. However, suppression of longissimus muscle growth by food deprivation (3 days) did not alter (P > 0.15) myostatin expression in either 4- or 7-wk-old piglets. Additionally, myostatin mRNA abundance was not changed by porcine growth hormone administration in growing animals. These data indicate that myostatin expression in skeletal muscle peaks prenatally and that greater expression is associated with low birth weight. Expression in mammary gland indicates a possible role for myostatin in mammary gland development and/or lactation.
Ultra-low power FSK receiver for body area networks with automatic frequency control

In this paper we present an ultra-low-power receiver geared towards body area networks (BAN). The presented wideband-FSK receiver consumes only 382. 5μW while achieving a BER of 10-3 at -81dBm sensitivity for 12.5kbps. The bit rate is scalable up to 625kbps, enabling a trade-off between sensitivity and bit rate. Taking advantage of the short-range nature of BAN applications, a mixer-first architecture is proposed, leading to a good dynamic range, given the DC power consumption. To further decrease the power consumption a free-running digitally controlled oscillator (DCO), tunable from 782MHz to 932MHz, is implemented, that is controlled by a data-aided automatic frequency control (AFC) loop, making the receiver resilient against DCO frequency variations.
Some "Principles" of Organization

mW mTHEN men turn their attention systematically to some area of social activity hitherto neglected, the first practitioners of the new art seek for themselves the prestige that today goes with science, as witness the confident talk about "principles of administration" that characterized the early writings of the first American specialists in the study of public administration. A bold claim for the sanctions of science was that of W. F. Wil-
Moral Distress Among Healthcare Professionals at a Health System

ABSTRACT Moral distress is increasingly recognized as a problem affecting healthcare professionals. If not addressed, it may create job dissatisfaction, withdrawal from the moral dimensions of patient care, or even leaving the profession. Using the 21-Moral Distress Scale–Revised to assess moral distress, 323 surveys were received from 5 healthcare disciplines. The overall results showed that all disciplines experienced moderate to high actual moral distress, related to similar and/or different patient care situations.
Multi-polarization reconfigurable omnidirectional antenna

A new multi-polarization reconfigurable omnidirectional antenna is proposed. The antenna consists of a top-loaded monopole for vertically polarized working state (VP), a circular loop for horizontally polarized working state (HP). The circularly polarized working state (CP) is achieved by exciting the monopole and the loop simultaneously with different phases. It is shown that the bandwidth overlapped for VP, HP, and CP is about 25% (1.7–2.2 GHz) with good omnidirectional patterns.
Metabolic change in the right dorsolateral prefrontal cortex and its correlation with symptom severity in patients with generalized anxiety disorder: Proton magnetic resonance spectroscopy at 3 Tesla

A few neuroimaging studies have demonstrated the key brain areas associated with generalized anxiety disorder (GAD). However, the brain metabolic changes in the dorsolateral prefrontal cortex (DLPFC) of patients with GAD are unclear. This study utilized 3‐Tesla proton magnetic resonance spectroscopy (1H‐MRS) to assess the DLPFC metabolic change and its correlation with symptom severity in patients with GAD.
Misreport of Vote Choice in U.S. Senate and Gubernatorial Elections

Previous research has found strong evidence of a pro-winner vote misreport bias in the National Election Studies (NES). We extend this research by examining the reported vote for U.S. senator and governor in the 1990, 1992, and 1994 NES and in the 1990 and 1992 Senate Election Studies (SES). We find continuing evidence of a pro-winner misreport problem. In contrast, we uncover no significant pro-winner bias in state exit polls conducted by the media. We test two commonly asserted explanations of the source of this misreport bias, but find no evidence that the problem is related either to the number of days between the election and the survey interview or to incumbency. Finally, we test a model of the misreport process that suggests that less politically engaged and less politically sophisticated voters are most likely to over-report support for the winner. Our results here are mixed; we find some evidence that Independents are more likely to misreport in favor of the winner, but we find no evidence that education level affects the likelihood of misreporting.
A column readout channel for infrared and terahertz bolometers with direct analog to digital conversion

This paper describes a readout channel suitable for infrared and terahertz bolometric sensors arrays where the signal integration is performed simultaneously with the analog-to-digital conversion in a columnwise architecture. By exploiting the need of an integrator both in conventional IR readout channels and incremental converters, the proposed circuit implements a 5-bit continuous-time incremental conversion during signal integration, then the same electronics is used to perform an additional 6-bit algorithmic conversion on the integrator residual voltage. A prototype of the channel has been fabricated in standard CMOS technology (0.35μm 2P4M) featuring 11-bit digital output at 7.12ksamples/s and occupying an area of 0.0301mm2 with a power consumption of only 90μW from a supply of 3.3V.
Expression of Osteopontin in Cisplatin-Induced Tubular Injury

Osteopontin (OPN) is considered as a key protein in cell regeneration. OPN is thought to have many functions in cell-cell binding and cell-matrix binding via OPN receptors in various organs. But there is little information on the precise role of OPN. To clarify the functional role of OPN in tubular injury, we performed in situ hybridization and immunohistochemical analysis of the expression of OPN in a renal cortical necrosis model induced by cisplatin from the acute injury to late recovery phases. In the acute injury phase, both mRNA and protein of OPN were markedly induced in damaged tubular lumens with cell debris. In the late recovery phase, on the other hand, OPN protein and mRNA were observed in dilated and flattened tubular epithelial cells showing a regenerative appearance. Most of these cells were also immunostained with CD44, a receptor of OPN. PCNA staining was also co-localized with these expressions. In light of the CD44 function regulating cell proliferation, these findings suggest that OPN may contribute to regeneration of tubular epithelial cells during the acute to late recovery phases of cortical tubular damage induced by cisplatin.
High molecular weight RNAs and small interfering RNAs induce systemic posttranscriptional gene silencing in plants

Posttranscriptional gene silencing (PTGS) in transgenic plants is an epigenetic form of RNA degradation related to PTGS and RNA interference (RNAi) in fungi and animals. Evidence suggests that transgene loci and RNA viruses can generate double-stranded RNAs similar in sequence to the transcribed region of target genes, which then undergo endonucleolytic cleavage to generate small interfering RNAs (siRNA) that promote degradation of cognate RNAs. The silent state in transgenic plants and in Caenorhabditis elegans can spread systemically, implying that mobile silencing signals exist. Neither the chemical nature of these signals nor their exact source in the PTGS pathway is known. Here, we use a positive marker system and real-time monitoring of green fluorescent protein expression to show that large sense, antisense, and double-stranded RNAs as well as double-stranded siRNAs delivered biolistically into plant cells trigger silencing capable of spreading locally and systemically. Systemically silenced leaves show greatly reduced levels of target RNA and accumulate siRNAs, confirming that RNA can induce systemic PTGS. The induced siRNAs represent parts of the target RNA that are outside of the region of homology with the triggering siRNA. Our results imply that siRNAs themselves or intermediates induced by siRNAs could comprise silencing signals and that these signals induce self-amplifying production of siRNAs.
LKB1 Associates with Brg1 and Is Necessary for Brg1-induced Growth Arrest*

Inactivating mutations in the serine-threonine kinase LKB1 (STK11) are found in most patients with Peutz-Jeghers syndrome; however the function of LKB1 is unknown. We found that LKB1 binds to and regulates brahma-related gene 1 (Brg1), an essential component of chromatin remodeling complexes. The association requires the N terminus of LKB1 and the helicase domain of Brg1 and LKB1 stimulates the ATPase activity of Brg1. Brg1 expression in SW13 cells induces the formation of flat cells indicative of cell cycle arrest and senescence. Expression of a kinase-dead mutant of LKB1, SL26, in SW13 cells blocks the formation of Brg1-induced flat cells, indicating that LKB1 is required for Brg1-dependent growth arrest. The inability of mutants of LKB1 to mediate Brg1-dependent growth arrest may explain the manifestations of Peutz-Jeghers syndrome.
Analysis of Household level Determinants of food security in rural Ethiopia: Evidence from North Gondar zone

Abstract Analysis of Household level Determinants of food security in rural Ethiopia: Evidence from Northern Gondar zone Food insecurity is a major challenge for Ethiopia and for many African countries. This paper assesses household food security and identifies factors affecting food security in two districts of North Gondar zone using household survey from 2016/17. A binary logit model has been used because the dependent variable is dichotomous. A clear understanding of the major causes of food insecurity helps policy makers and planners to formulate new policies that enhance food security. Therefore, this study was conducted to measure food security/insecurity status of households, to identify factors influencing farm household’s food security. In order to achieve these objectives biophysical, demographic and socio-economic data were collected from 200 randomly selected households in a two-step sampling procedure. The survey result shows that about 75% of sample farmers were food insecure. Moreover, based on survey data, the empirical results from logistic regression revealed that seven variables, namely age, family size, amount of cultivated land, livestock ownership, agro ecological zone, household head sex and household participation in any off/non-farm income are significant factors influencing the odds ratio of a household food security status. Thus, the finding implies that female-headed households need support in order to improve their food security. Furthermore, improving access to land and its utilization based on comparative advantage could improve household food security. Family planning can also be important to balance demand and supply of food in such areas. Key Words: Determinant, Food Security, Logistic Regression, HFBM