Miracle-dz/UniFAR-FTUs huggingface dataset:
The effects of impulsivity and proactive inhibition on reactive inhibition and the go process: insights from vocal and manual stop signal tasks

This study measured proactive and reactive response inhibition and their relationships with self-reported impulsivity. We examined the domains of both vocal and manual responding using a stop signal task (SST) with two stop probabilities: high and low probability stop (1/3 and 1/6 stops respectively). Our aim was to evaluate the effect stop probability would have on reactive and proactive inhibition. We tested 44 subjects and found that for the high compared to low probability stop signal condition, more proactive inhibition was evident and this was correlated with a reduction in the stop signal reaction time (SSRT). We found that reactive inhibition had a positive relationship with dysfunctional but not functional impulsivity in both vocal and manual domains of responding. These findings support the hypothesis that proactive inhibition may pre-activate the network for reactive inhibition.
Family Systems Perspective and Diabetes Type I: Reflective Analysis

The purpose of this paper is to reflectively explore diabetes from a family systems perspective. Specific discussion will involve current understanding of Type I Diabetes and Family Systems, understanding suffering of illness experience, and will provide comparison and contrast of effective behavioral interventions for families under the care of a marriage and family therapist. While moving expectations toward systemic understanding of Type I Diabetes will be explored, and a brief account of the researchers’ personal and present familial history within the discipline of marriage and family therapy will also be discussed.
Hispolon Protects against Acute Liver Damage in the Rat by Inhibiting Lipid Peroxidation, Proinflammatory Cytokine, and Oxidative Stress and Downregulating the Expressions of iNOS, COX-2, and MMP-9

The hepatoprotective potential of hispolon against carbon tetrachloride (CCl4)-induced liver damage was evaluated in preventive models in rats. Male rats were intraperitoneally treated with hispolon or silymarin once daily for 7 consecutive days. One hour after the final hispolon or silymarin treatment, the rats were injected with CCl4. Administration with hispolon or silymarin significantly decreased the alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in serum and increased the activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), and glutathione (GSH) content and decreased the malondialdehyde (MDA) content in liver compared with CCl4-treated group. Liver histopathology also showed that hispolon reduced the incidence of liver lesions induced by CCl4. In addition, hispolon decreased nitric oxide (NO) production and tumor necrosis factor (TNF-α), inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) activation in CCl4-treated rats. We also examined the involvement of matrix metalloproteinase (MMP)-9 in the development of CCl4-induced liver damage in rats. Hispolon inhibited the expression of MMP-9 protein, indicating that MMP-9 played an important role in the development of CCl4-induced rat liver damage. Therefore, we speculate that hispolon protects rats from liver damage through their prophylactic redox balancing ability and anti-inflammation capacity.
Interface Specification Assurance Methods

PSL supports property inheritance by verification units. The lack of formal semantics of the inherit operator is an obstacle to reduce the complexity of system design and verification. This paper presents a verification-layer specification assurance tool. Based on the component-based design methodology, we propose a principled organization of component specifications, and apply SAT solvers to verify the consistency of specifications, the compatibility of components, the refinement relation among specifications, and the correctness of specification inheritance. We also discuss the implementation aspect of such a tool
The assessment of the geometry of dinucleotide steps in double-helical DNA; a new local calculation scheme.

In this paper, we develop a new local Euler-angle-based scheme for assessing the internal kinematics or geometry of a general dinucleotide step in double-helical DNA. The geometry of a dinucleotide step is completely defined by: (1) the base-pair parameters that describe the relative position and orientation of one base with respect to the other in a standard Watson-Crick base-pair, and (2) the step parameters that describe the relative position and orientation of the two base-pairs. The key feature of our scheme is that it makes use of the concept of a mid-step reference frame. In addition to ensuring that identical values of step parameters are obtained irrespective of the direction of reckoning of a dinucleotide step (in the 5'-->3' direction along either strand), this mid-step-triad concept leads to local definitions of the step parameters that render them independent of the overall global conformation of the oligomer in question. In addition to presenting our own calculation scheme we also examine critically the most widely used package for the calculation of some of the step and base-pair parameters, viz, the NEWHELIX suite of programmes by R.E. Dickerson. Finally, a dodecamer, a decamer and an octamer are arbitrarily selected from a public data-base (N.D.B at Rutgers), and their step parameters are calculated by using both NEWHELIX and the proposed scheme. A comparison of the results is given whereby it is shown that for the step parameters: Helical Twist and Slide, and the base-pair parameters Propeller and Buckle, NEWHELIX and our proposed scheme give rather similar values. Substantial differences are seen, however, in the case of Rise. Two alternative definitions are given by NEWHELIX for the calculation of Roll and Tilt. Whereas one definition agrees well with our proposed scheme, the other is substantially different.
The Estimate of Risk of Adolescent Sexual Offense Recidivism (ERASOR): Preliminary Psychometric Data

The Estimate of Risk of Adolescent Sexual Offense Recidivism (ERASOR) is an empirically guided checklist designed to assist clinicians to estimate the short-term risk of a sexual reoffense for youth aged 12–18 years of age. The ERASOR provides objective coding instructions for 25 risk factors (16 dynamic and 9 static). To investigate the psychometric properties, risk ratings were collected from 28 clinicians who evaluated 136 adolescent males (aged 12–18 years) following comprehensive, clinical assessments. Preliminary psychometric data (i.e., interrater agreement, item–total correlation, internal consistency) were found to be supportive of the reliability and item composition of the tool. ERASOR ratings also significantly discriminated adolescents based on whether or not they had previously been sanctioned for a prior sexual offense.
Cytotoxic T Lymphocyte–based Control of Simian Immunodeficiency Virus Replication in a Preclinical AIDS Vaccine Trial

Recently, encouraging AIDS vaccine trials in macaques have implicated cytotoxic T lymphocytes (CTLs) in the control of the simian human immunodeficiency virus SHIV89.6P that induces acute CD4+ T cell depletion. However, none of these vaccine regimens have been successful in the containment of replication of the pathogenic simian immunodeficiency viruses (SIVs) that induce chronic disease progression. Indeed, it has remained unclear if vaccine-induced CTL can control SIV replication. Here, we show evidence suggesting that vaccine-induced CTLs control SIVmac239 replication in rhesus macaques. Eight macaques vaccinated with DNA-prime/Gag-expressing Sendai virus vector boost were challenged intravenously with SIVmac239. Five of the vaccinees controlled viral replication and had undetectable plasma viremia after 5 wk of infection. CTLs from all of these five macaques rapidly selected for escape mutations in Gag, indicating that vaccine-induced CTLs successfully contained replication of the challenge virus. Interestingly, analysis of the escape variant selected in three vaccinees that share a major histocompatibility complex class I haplotype revealed that the escape variant virus was at a replicative disadvantage compared with SIVmac239. These findings suggested that the vaccine-induced CTLs had “crippled” the challenge virus. Our results indicate that vaccine induction of highly effective CTLs can result in the containment of replication of a highly pathogenic immunodeficiency virus.
Release of growth factors from a reinforced collagen GAG matrix supplemented with platelet rich plasma: Influence on cultured human meniscal cells

Damage to meniscal cartilage has been strongly linked to accelerated articular wear and consequently to osteoarthritis. Damage might be ameliorated by delivery of growth factors from platelet rich plasma (PRP) via a fiber reinforced collagen matrix designed for meniscal repair. PRP composition, release of growth factors, and influence on meniscal cell growth and gene expression were investigated. PRP was prepared using Harvest Smartprep (HS‐PRP), Cascade Fibrinet (CF‐PRP), and a simple centrifuge protocol (DC‐PRP) from four donors each. CF‐PRP had the highest ratio of platelets, with very few other blood cell types. HS‐PRP had the highest total number of platelets but also contained high levels of red and white blood cells. Absorbed to collagen matrices HS‐PRP released the highest levels of TGF‐β1 and PDGF‐AB with DC‐PRP the most IGF‐1. Cumulative release from collagen matrix was 48 ng/cm3 IGF‐1, 96 ng/cm3 TGF‐β1, and 9.6 ng/cm3 PDGF‐AB. Collagen matrix with PRP was able to increase meniscal cell number above peripheral whole blood and up‐regulated gene expression of Aggrecan, Collagen type I (α1), and Elastin (3.3 ± 0.8‐fold, 2.9 ± 0.6‐fold, 4.0 ± 1.4‐fold, respectively). Demonstrating that PRP combined with fiber reinforced collagen matrix could influence meniscal cells and might be of use for treating meniscal defects. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 32:273–278, 2014.
Association between food intake and oral health in elderly: SEPAHAN systematic review no. 8

Dental status may influence food intake. The aim of this review was to summarize the earlier investigations on the association between food intake and dental status. We searched the electronic databases of PubMed and the Cochrane library for articles published until 30 February, 2012. To reach the related published articles, Medical Subject Heading (MeSH) terms of ‘oral health,’ ‘masticatory performance,’ ‘dental status,’ and ‘eating’ or ‘food intake’ were used. We included all research articles in the English language that (1) had used the random sampling method, and (2) had investigated the association between dental status and nutrient intake in elderly, non-denture wearer individuals, with no systemic illness. The findings of the seven original research articles had a great variation. Four of them supported a strong association between dietary intake and dental status and three of them found that there was no association between these variables. Most investigations found a significant relationship between the oral health status and nutrient intake; however, longitudinal studies were required for a better understanding of the diet-oral health relations.
Response to smallpox vaccine in persons immunized in the distant past.

CONTEXT There is renewed interest in use of smallpox vaccine due to the potential for a bioterrorist attack. This would involve vaccinating health care workers who were previously vaccinated. OBJECTIVE To evaluate the use of diluted vaccinia virus in vaccination of previously vaccinated (non-naive) participants. DESIGN, SETTING, AND PARTICIPANTS Eighty non-naive participants, aged 32 to 60 years, were randomized in a single-blinded study to receive either undiluted or diluted (1:3.2, 1:10, or 1:32) doses of smallpox vaccine. A comparison group, aged 18 to 31 years, of 10 vaccinia-naive participants received undiluted vaccine. Participants were enrolled between April 1 and May 15, 2002, at the National Institute of Allergy and Infectious Diseases Vaccine and Treatment Evaluation Unit at Saint Louis University, St Louis, Mo. INTERVENTION Smallpox vaccine was administered by scarification using 15 skin punctures in the deltoid region of the arm. MAIN OUTCOME MEASURES Presence of a major reaction, defined as a vesicular or pustular lesion or area of palpable induration surrounding a central lesion following vaccination, and measures of viral shedding and antibody titers. RESULTS Initial vaccination resulted in a major reaction in 64 of 80 non-naive participants. Ninety-five percent of non-naive participants had major reactions in the undiluted group, 90% in the 1:3.2 dilution group, 81% in the 1:10 dilution group, and 52.6% in the 1:32 dilution group. All (n = 10) of the vaccinia-naive participants had major reactions. Compared with vaccinia-naive participants, non-naive participants had significantly smaller skin lesions (P =.04) and significantly less incidence of fever (P =.02). Preexisting antibody was present in 76 of 80 non-naive participants. Antibody responses were significantly higher and occurred more rapidly in the non-naive participants compared with the vaccinia-naive participants (P =.002 for day 28 and P =.003 for 6 months). Vaccinia-naive participants shed virus from the vaccination site 2 to 6 days longer and had significantly higher peak mean viral titers when compared with the non-naive participants (P =.002). CONCLUSIONS Previously vaccinated persons can be successfully revaccinated with diluted (<or=1:10) smallpox vaccine. Fewer adverse reactions were observed in this study of non-naive participants when compared with events in vaccinia-naive participants, which may be due to immunologic memory.
New data structures for orthogonal range searching

We present new general techniques for static orthogonal range searching problems in two and higher dimensions. For the general range reporting problem in R/sup 3/, we achieve query time O(log n+k) using space O(n log/sup 1+/spl epsiv// n), where n denotes the number of stored points and k the number of points to be reported. For the range reporting problem on an n/spl times/n grid, we achieve query time O(log log n+k) using space O(n log/sup /spl epsiv// n). For the two-dimensional semi-group range sum problem we achieve query time O(log n) using space O(n log n).
Content Delivery Network Interconnection (CDNI) Control Interface / Triggers

This document describes the part of the Content Delivery Network Interconnection (CDNI) Control interface that allows a CDN to trigger activity in an interconnected CDN that is configured to deliver content on its behalf. The upstream CDN can use this mechanism to request that the downstream CDN pre-position metadata or content or to request that it invalidate or purge metadata or content. The upstream CDN can monitor the status of activity that it has triggered in the downstream CDN.
Standards-to-Standards Linkage Under Title III: Exploring Common Language Demands in ELD and Science Standards

Abstract Under Title III of the No Child Left Behind (NCLB) Act of 2001 (NCLB, 2001b) every state needs to show linkage between state content standards and state English language development standards as input to the development of state English proficiency tests. This article argues that Title III presents a unique opportunity to explore how different content standards can be linked on a common dimension. This article focuses on evaluating the degree to which content standards, such as English language arts and science, overlap with English language development standards in terms of implicit and explicit language demands placed on students. This helps ensure that language learners are exposed to types of language that will assist them in being successful in academic contexts.
The association between childhood sexual abuse and adult female sexual difficulties

Childhood sexual abuse (CSA) has been associated with a number of long-term negative consequences, including depression, anxiety and psychosomatic symptomology. Sexual trauma has also been linked to problematic sexual functioning and sexual behaviour in adulthood. This paper critically evaluates the current literature on CSA and adult sexuality and identifies the main sexual difficulties experienced by women with a history of CSA. The authors also present a preliminary theoretical model of the association between CSA and problematic sexual outcome. This model takes into consideration literature that directly critiques previous models of association and identifies important factors that have not adequately been accounted for in the reviewed literature.
Competitividad de la acuicultura española: Modelos explicativos

El objetivo de este articulo es la determinacion de modelos explicativos de la competitividad del sector acuicola en Espana, contrastando la incidencia en dichos modelos de factores endogenos contenidos en la teoria de recursos y capacidades. Tras la preceptiva recension teorica, la metodologia empleada consiste en el contraste y verificacion de dos hipotesis sobre la aplicabilidad de dicha teoria respecto a una investigacion empirica que combina resultados de una encuesta y ratios extraidos de la base de datos SABI de 99 empresas acuicolas espanolas (mediante los programa SPSS y AMOS). Los resultados obtenidos (modelos factorial y path de ecuaciones estucturales) refieren la incidencia diferencial o prevalencia de ciertas variables sobre otras contenidas en la teoria, para el caso de la competividad de la acuicultura espanola. A la luz de la reespecificacion de los modelos propuestos, podemos concluir que la competitividad de la acuicultura espanola se relaciona con la generacion de valor, la productividad, el tamano, la innovacion y el grado de especializacion.
Under-provision of medical care for vascular diseases for people with dementia in primary care: a cross-sectional review.

BACKGROUND Vascular diseases contribute to the causation and progression of clinical dementia. AIM To evaluate the quality of medical care for vascular diseases provided to people with dementia, the patient and practice characteristics that influence quality, and to compare care with that provided to those without dementia. DESIGN AND SETTING Observational, cross-sectional review of primary care records of people with dementia from 52 general practices from five primary care trusts in the UK, and comparison with publicly available summary data on patients without dementia. METHOD A total of 700 patients with ≥1 diagnosed vascular disease or risk factor were identified from dementia registers. Quality of care was measured on 30 indicators from the UK Quality and Outcomes Framework (QOF) for hypertension, coronary heart disease, stroke, diabetes mellitus, atrial fibrillation, heart failure, and smoking. Overall quality of vascular care was calculated for each patient with dementia. RESULT Level of care received by people with dementia was significantly lower compared with those without dementia for 22 of 30 (73%) indicators; most notably for measurement processes such as peripheral pulses check and neuropathy testing for diabetes, and cholesterol measures for stroke. Among people with dementia, women, those in care homes, and those with fewer comorbid physical conditions and medications were associated with lower scores for overall quality of vascular care. CONCLUSION The quality of medical care provided to people with dementia with regard to vascular diseases is not concordant with quality, as defined by the QOF. Research is needed to improve access to high-quality care.
The EU: Standing Aside from the Changing Global Balance of Power?

The EU has developed its global role in recent years. This has taken place by developing procedures for foreign policy and in the deployment of civilian and military missions internationally. However, the EU suffers from weaknesses that limit its ability to exercise significant global influence and that are apparent in the EU's relationship with the rising powers. The article analyses these limitations which encompass the EU's ‘hardware’ — its capacity to deploy fully the capabilities of all its constituent Member States – and failings in its ‘software’ — incoherence and inconsistency in the definition and application of its ideas guiding the EU's global role.
HAMSI: Distributed Incremental Optimization Algorithm Using Quadratic Approximations for Partially Separable Problems

We propose HAMSI, a provably convergent incremental algorithm for solving large-scale partially separable optimization problems that frequently emerge in machine learning and inferential statistics. The algorithm is based on a local quadratic approximation and hence allows incorporating a second order curvature information to speed-up the convergence. Furthermore, HAMSI needs almost no tuning, and it is scalable as well as easily parallelizable. In large-scale simulation studies with the MovieLens datasets, we illustrate that the method is superior to a state-of-the-art distributed stochastic gradient descent method in terms of convergence behavior. This performance gain comes at the expense of using memory that scales only linearly with the total size of the optimization variables. We conclude that HAMSI may be considered as a viable alternative in many scenarios, where first order methods based on variants of stochastic gradient descent are applicable.
Molecular diagnosis of lymphocytic infiltrates of the skin.

BACKGROUND Advances in our understanding of the molecular genetics of lymphocyte antigen receptors (B-cell immunoglobulin and T-cell antigen receptor), have led to the application of molecular biologic techniques to molecularly characterize lymphocytic infiltrates of the skin. Molecular diagnosis refers to the application of these techniques as a diagnostic aid in the clinicopathologic evaluation of cutaneous lymphocytic infiltrates. OBSERVATION Molecular studies have clinical application in the determination of lineage and detection of retroviruses in cutaneous lymphoid neoplasms, distinguishing between lymphoproliferative and reactive infiltrates, and staging and monitoring response to therapy in cutaneous T-cell lymphoma. Southern blot analysis of immunoglobulin and T-cell antigen receptor gene rearrangements may fail to aid the clinician in establishing a diagnosis of a cutaneous malignancy due to the limits of detection sensitivity in minimally infiltrated lesions (eg, parapsoriasis and patch-stage mycosis fungoides) or the still uncertain prognostic significance of clonality in benign cutaneous diseases (eg, follicular mucinosis, pityriasis lichenoides et varioliformis acuta, lymphomatoid papulosis, and cutaneous lymphoid hyperplasia). CONCLUSIONS Molecular studies have enormous research value, providing new means to explore the pathogenesis and clonal evolution of lymphoproliferative skin diseases. Presently, however, they have limited applications as an independent diagnostic tool. As our understanding of the clinical and biologic significance of the molecular detection of clonal lymphocyte populations in the skin expands and as the application of polymerase chain reaction amplification provides us with greater detection sensitivity and specificity, the clinical utility of molecular diagnosis of lymphocytic infiltrates of the skin will be enhanced.