Miracle-dz/UniFAR-FTUs huggingface dataset:
Specialist Trading and the Price Discovery Process of NYSE-Listed Non-U.S. Stocks

We examine the contribution of U.S. trading to the price discovery process of 64 British and French companies cross-listed on the NYSE. We focus our analysis on the role of the information environment of NYSE specialists who make market in non-U.S. securities. We hypothesize that concentration of stocks from a given country in an individual specialist’s portfolio increases the U.S. share in price discovery by reducing information asymmetries. Moreover, we expect the impact of the concentration on the share in price discovery to be more pronounced for less liquid stocks, for which in the presence of limited own order flow information can be extracted from order flow to clustered, closely related firms. Our crosssectional results strongly support our hypothesis and are robust to the approach used to calculate information shares, potential endogeneity effects, impact of stock reallocations, length of the overlapping period, and currency of denomination of both market prices. JEL Classification: G14, G15
Critical issues in mapping neural networks on message-passing multicomputers

The architectural requirements for efficiently simulating large neural networks on a multicomputer system with thousands of fine-grained processors and distributed memory are investigated. Models for characterizing the structure of a neural network and the function of individual cells are developed. These models provide guidelines for efficiently mapping the network onto multicomputer technologies such as the hypercube, hypernet, and torus. They are further used to estimate the amount of interprocessor communication bandwidth required, and the number of processors needed to meet a particular cost/performance goal. Design issues such as memory organization and the effect of VLSI technology are also considered. <<ETX>>
High efficiency non-isolated three port DC-DC converter for PV-battery systems

This paper presents a nonisolated Three Port Converter (TPC) with a unidirectional port for photovoltaic (PV) panels and a bidirectional port for energy storage. With the proposed topology single power conversion is performed between each port, so high efficiencies are obtained. A theoretical analysis is carried out to analyze all operating modes and design considerations with the main equations are given. A 4kW laboratory prototype is developed and tested under all operating conditions. Results obtained feature on efficiencies higher than 97% for all operating modes and all power levels from light load to full load.
Adaptive Mutation in Saccharomyces cerevisiae

ABSTRACT Adaptive mutation is a generic term for processes that allow individual cells of nonproliferating cell populations to acquire advantageous mutations and thereby to overcome the strong selective pressure of proliferation-limiting environmental conditions. Prerequisites for an occurrence of adaptive mutation are that the selective conditions are nonlethal and that a restart of proliferation may be accomplished by some genetic change in principle. The importance of adaptive mutation is derived from the assumption that it may, on the one hand, result in an accelerated evolution of microorganisms and, on the other, in multicellular organisms may contribute to a breakout of somatic cells from negative growth regulation, i.e., to cancerogenesis. Most information on adaptive mutation in eukaryotes has been gained with the budding yeast Saccharomyces cerevisiae. This review focuses comprehensively on adaptive mutation in this organism and summarizes our current understanding of this issue.
Towards name-based trust and security for content-centric network

Trust and security have been considered as built-in properties for future Internet architecture. Leveraging the concept of named content in recently proposed information centric network, we propose a name-based trust and security protection mechanism. Our scheme is built with identity-based cryptography (IBC), where the identity of a user or device can act as a public key string. Uniquely, in named content network such as content-centric network (CCN), a content name or its prefixes can be used as public identities, with which content integrity and authenticity can be achieved with IBC algorithms. The trust of a content is seamlessly integrated with the verification of the content's integrity and authenticity with its name or prefix, instead of the public key certificate of its publisher. In addition, flexible confidentiality protection is enabled between content publishers and consumers. For scalable deployment purpose, we further propose to use a hybrid scheme combined with traditional public-key infrastructure (PKI) and IBC. We have implemented this scheme with CCNx open source project on Android.
Direcionadores na Difusão da Estratégia de Postponement: Casos de Empresas Brasileiras

The purpose of this article is to investigate the adoption of postponement in the business environment in Brazil and which factors favor its implementation. This study used the methodology of multi-case studies to investigate this phenomenon that is well known in the literature, but rare in real business life. Results suggest that the implementation of postponement requires not only the reconfiguration of the logistics systems, but changes in the relationship between members in the supply chain, investments in technology and the strategic vision of their leaders. New prerequisites were identified, suggesting that the existing framework for implementation of postponement needs to be extended. Companies should invest in change of products, processes, supply chain relationships and organization to enjoy the benefits of postponement.
Dengue virus-specific human T cell clones. Serotype crossreactive proliferation, interferon gamma production, and cytotoxic activity

The severe complications of dengue virus infections, hemorrhagic manifestation and shock, are much more commonly observed during secondary infections caused by a different serotype of dengue virus than that which caused the primary infections. It has been speculated, therefore, that dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) are caused by serotype crossreactive immunopathological mechanisms. We analyzed clones of dengue serotype crossreactive T lymphocytes derived from the PBMC of a donor who had been infected with dengue 3 virus. These PBMC responded best to dengue 3 antigen, but also responded to dengue 1, 2, and 4 antigens, in bulk culture proliferation assays. 12 dengue antigen-specific clones were established using a limiting dilution technique. All of the clones had CD3+ CD4+ CD8 phenotypes. Eight clones responded to dengue 1, 2, 3, and 4 antigens and are crossreactive, while four other clones responded predominantly to dengue 3 antigen. These results indicate that the serotype crossreactive dengue-specific T lymphocyte proliferation observed in bulk cultures reflects the crossreactive responses detected at the clonal level. Serotype crossreactive clones produced high titers of IFN- gamma after stimulation with dengue 3 antigens, and also produced IFN- gamma to lower levels after stimulation with dengue 1, 2, and 4 antigens. The crossreactive clones lysed autologous lymphoblastoid cell line (LCL) pulsed with dengue antigens, and the crossreactivity of CTL lysis by T cell clones was consistent with the crossreactivity observed in proliferation assays. Epidemiological studies have shown that secondary infections with dengue 2 virus cause DHF/DSS at a higher rate than the other serotypes. We hypothesized that the lysis of dengue virus-infected cells by CTL may lead to DHF/DSS; therefore, the clones were examined for cytotoxic activity against dengue 2 virus-infected LCL. All but one of the serotype crossreactive clones lysed dengue 2 virus-infected autologous LCL, and they did not lyse uninfected autologous LCL. The lysis of dengue antigen-pulsed or virus-infected LCL by the crossreactive CTL clones that we have examined is restricted by HLA DP or DQ antigens. These results indicate that primary dengue virus infections induce predominantly crossreactive memory CD4+ T lymphocytes. These crossreactive T lymphocytes proliferate and produce IFN-gamma after stimulation with a virus strain of another serotype, and demonstrate crossreactive cyotoxic activity against autologous cells infected with heterologous dengue viruses. (ABSTRACT TRUNCATED AT 400 WORDS)
Terminal Semantics for Codata Types in Intensional Martin-Löf Type Theory

In this work, we study the notions of relative comonad and comodule over a relative comonad, and use these notions to give a terminal coalgebra semantics for the coinductive type families of streams and of infinite triangular matrices, respectively, in intensional Martin-L\"of type theory. Our results are mechanized in the proof assistant Coq.
Role of Monocyte Chemoattractant Protein-1 in Cardiovascular Remodeling Induced by Chronic Blockade of Nitric Oxide Synthesis

BackgroundChronic inhibition of endothelial nitric oxide (NO) synthesis by the administration of N&ohgr;-nitro-l-arginine methyl ester (L-NAME) to rats induces early vascular inflammatory changes (monocyte infiltration into coronary vessels and monocyte chemoattractant protein-1 [MCP-1] expression) as well as subsequent arteriosclerosis (medial thickening and perivascular fibrosis) and cardiac fibrosis. However, the role of MCP-1 in this process is not known. Methods and ResultsWe investigated the effect of a specific monoclonal anti–MCP-1 neutralizing antibody in rats treated with L-NAME to determine the role of monocytes in the regulation of cardiovascular remodeling. We found increased expression of MCP-1 mRNA in vascular endothelial cells and monocytes in inflammatory lesions. Cotreatment with an anti–MCP-1 antibody, but not with control IgG, prevented the L-NAME–induced early inflammation and reduced late coronary vascular medial thickening. In contrast, the anti–MCP-1 antibody did not decrease the development of perivascular fibrosis, the expression of transforming growth factor (TGF)-&bgr;1 mRNA, or systolic pressure overload induced by L-NAME administration. ConclusionsThese results suggest that MCP-1 is necessary for the development of medial thickening as well as monocyte recruitment. In contrast, the pathogenesis of fibrosis may involve other factors, such as TGF-&bgr;1.
Effects of ethanol extracts from Adzuki bean (Phaseolus angularis Wight.) and Lima bean (Phaseolus lunatus L.) on estrogen and progesterone receptor phenotypes of MCF‐7/BOS cells

In this study, the possible molecular mechanisms involved in the estrogen‐like activities of ethanol extracts from two common Chinese legumes, i.e. Adzuki bean (Phaseolus angularis Wight.) and Lima bean (Phaseolus lunatus L.) were investigated. Reverse transcription‐polymerase chain reaction (RT‐PCR) measurement and western blot analysis were conducted to detect the functional mRNA and protein expressions, while immunofluorescence was used to determine the estrogen receptor (ER) intracellular distribution in the MCF‐7/BOS cell line. The results indicated that (1) both mRNA and protein levels of progesterone receptor (PR) in the cell line increased after 48 h treatment with the extracts compared with those in the control; (2) Adzuki and Lima bean extracts might alter the ER intracellular distributions in two different manners: for the Adzuki bean, the ER appeared in both cytoplasm and nucleus, while for the Lima bean, it exhibited the same pattern as that of estradiol in which the ER almost disappeared in the nucleus and mainly occurred in the cytoplasm. Above all, the results showed a novel pattern of ER intracellular distribution in the MCF‐7/BOS cell line upon exposure to Adzuki bean extract, suggesting that different pathways were involved in the estrogen‐like activities of the ethanol extracts of Adzuki bean and Lima bean. Copyright © 2007 John Wiley & Sons, Ltd.
Berberis aristata Ameliorates Adjuvant-Induced Arthritis by Inhibition of NF-κB and Activating Nuclear Factor-E2-related Factor 2/hem Oxygenase (HO)-1 Signaling Pathway

ABSTRACT The present study was carried out to investigate the anti-arthritic activity of Berberis aristata hydroalcoholic extract (BAHE) in formaldehyde-induced arthritis and adjuvant-induced arthritis (AIA) model. Arthritis was induced by administration of either formaldehyde (2% v/v) or CFA into the subplantar surface of the hind paw of the animal. In formaldehyde-induced arthritis and AIA, treatment of BAHE at doses 50, 100 and 200 mg/kg orally significantly decreased joint inflammation as evidenced by decrease in joint diameter and reduced inflammatory cell infiltration in histopathological examination. BAHE treatment demonstrated dose-dependent improvement in the redox status of synovium (decrease in GSH, MDA, and NO levels and increase in SOD and CAT activities). The beneficial effect of BAHE was substantiated with decreased expression of inflammatory markers such as IL-1β, IL-6, TNF-R1, and VEGF by immunohistochemistry analysis in AIA model. BAHE increased HO-1/Nrf-2 and suppressed NF-κB mRNA and protein expression in adjuvant immunized joint. Additionally, BAHE abrogated degrading enzymes, as there was decreased protein expression of MMP-3 and -9 in AIA. In conclusion, we demonstrated the anti-arthritic activity of Berberis aristata hydroalcoholic extract via the mechanism of inhibition of NF-κB and activation of Nrf-2/HO-1.
Neuroprotective Effects of a Smoothened Receptor Agonist against Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats

The sonic hedgehog (Shh) signaling pathway plays a fundamental role in the central nervous system (CNS) development, but its effects on neural cell survival and brain repair after subarachnoid hemorrhage (SAH) has not been well-investigated. The present study was undertaken to evaluate the influence of an agonist of the Shh co-receptor Smoothened (Smo), purmorphamine (PUR), on early brain injury (EBI) as well as the underlying mechanisms after SAH. PUR was administered via an intraperitoneal injection with a dose of 0.5, 1, and 5 mg/kg at 2, 6, 24, and 46 h after SAH in rat model. The results showed that PUR treatment significantly ameliorated brain edema, improved neurobehavioral function, and attenuated neuronal cell death in the prefrontal cortex (PFC), associated with a decrease in Bax/Bcl-2 ratio and suppression of caspase-3 activation at 48 h after SAH. PUR also promoted phospho-ERK levels. Additionally, PUR treatment markedly decreased MDA concentration accompanied with the elevation in the expression of nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 in PFC. Notably, PUR treatment significantly reversed the changes of Shh pathway mediators containing Patched, Gli1, and Shh by SAH insult, and the neuroprotection of PUR on SAH was blocked by Smo antagonist cyclopamine. These results indicated that PUR exerts neuroprotection against SAH-evoked injury in rats, mediated in part by anti-apoptotic and anti-oxidant mechanism, up-regulating phospho-ERK levels, mediating Shh signaling molecules in the PFC.
A non-invasive biopotential electrode for the correct detection of bioelectrical currents

An advanced current measure probe is described for biological applications. Singular points on the body skin emit a semi-constant current that could be potentially useful for a medical diagnosis of the body organs to which any singular point is connected. In order to achieve an accurate and reliable analysis of the emitted current, all the error sources have been studied in order to design a ready to use probe.
Representational Difference Analysis and Real-Time PCR for Strain-Specific Quantification of Lactobacillus sobrius sp. nov

ABSTRACT Lactobacillus sobrius sp. nov., which was recently isolated from the intestine of weaning piglets, has potential probiotic properties. To follow the fate of L. sobrius strain 001T in dietary interventions, a novel and strain-specific quantitative detection procedure was developed. This procedure was based on the isolation of specific genomic fragments from the type strain by representational difference analysis and their detection by real-time PCR. The described strain-specific quantification approach may be used in studies aimed at tracking bacterial strains added to specific environments.
Antecedents and consequences of employability orientation

This study investigated the antecedents and the consequences of employability orientation, i.e., employees' attitudes toward developing their employability for the organization. Supporting the hypotheses, the results showed that employability orientation was positively related to openness, initiative, and the career anchors of managerial competence and variety, and negatively related to tenure, continuance commitment, and the career anchors of technical competence and security. Career anchors mediated the relationship between openness, initiative, and employability orientation; continuance commitment mediated the relationship between tenure and employability orientation. No relationships were found between affective commitment, career development support, and employability orientation; an unexpected negative relationship existed between employability orientation and perceptions of organizational support. Employability orientation proved a strong predictor of employability activities. The implications of t.
The effect of treadmill exercise on azoxymethane-induced intestinal neoplasia in the male Fischer rat on two different high-fat diets.

A total of 120 eight-week-old male rats were exposed to azoxymethane (15 mg/kg body wt in saline s.c.) on Days 1, 4, and 8. Two days after the last injection of carcinogen, the rats were randomized into four experimental groups: two groups were given a chow high in corn oil (23% corn oil) and two groups a chow high in coconut oil (21% coconut oil and 2% corn oil). One group on each chow was kept sedentary, and one group was exposed to moderate exercise, running 2 km/day on weekdays for 38 weeks. At the end of the experiment, the exercising and sedentary rats fed coconut oil were significantly heavier than those fed corn oil. Among the rats fed the high-fat corn oil diet, exercise reduced the number of animals developing carcinomas in the colon (sedentary, 10; exercise, 0) and in the small intestine (sedentary, 5; exercise, 0). The same tendency was observed in the rats fed the coconut oil diet: colon (sedentary, 6; exercise, 3) and small intestine (sedentary, 3; exercise, 2). In the sedentary rats fed the high corn oil diet, 16 intestinal carcinomas were recorded; none were found in the exercised group. In the rats fed the high coconut oil diet, nine carcinomas were recorded in the sedentary groups as opposed to five in the exercised rats. Rats fed the high-fat coconut oil developed significantly fewer neoplasms than the rats fed the equally high-fat corn oil diet.
Ca 2 sparks and secretion in dorsal root ganglion neurons

*Institute of Molecular Medicine and †National Laboratory of Biomembrane and Membrane Biotechnology, Peking University, Beijing, China; §Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; ¶Department of Physiology, Health Science Center, Peking University, Beijing 100083, China; and **Laboratory of Cardiovascular Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892
Significance of macrophage tropism of SIV in the macaque model of HIV disease

Microglia, alveolar macrophages, and Langerhans cells are representatives of cells of macrophage lineage that are susceptible to infection with HIV‐1 and they play important roles in the pathogenesis of AIDS dementia, lymphoid interstitial pneumonia, and systemic viral invasion from mucosal surfaces, respectively. In contrast, elimination of CD4+ T cells with resultant development of immunosuppression and AIDS is thought to be reflective of the exclusive tropism of the virus for CD4+ T cells. Examination of these concepts in macaques infected with molecularly cloned strains of SIVmac suggested that all strains of the virus are both macrophage‐ and lymphocyte‐tropic and that all aspects of pathogenesis including loss of CD4+ T cells are dependent on infection in both cell types. However, viral clones that caused productive lytic infection in macrophages were less virulent than those which caused persistent nonproductive infection. The former caused subclinical and even immunizing infections, whereas the latter caused activation and productive infection in CD4+ T cells, AIDS, and systemic infection, even after inoculation of the virus on mucosal surfaces. If these findings on SIVmac are relevant to HIV‐1 disease, then demonstration that HIV‐1 isolates are macrophage‐tropic probably does not necessarily correlate with their pathogenic potential. J. Leukoc. Biol. 62: 12–19; 1997.
Sry expression level and protein isoform differences play a role in abnormal testis development in C57BL/6J mice carrying certain Sry alleles.

Transfer of certain Mus domesticus-derived Y chromosomes (Sry(DOM) alleles, e.g., Sry(POS) and Sry(AKR)) onto the C57BL/6J (B6) mouse strain causes abnormal gonad development due to an aberrant interaction between the Sry(DOM) allele and the B6-derived autosomal (tda) genes. For example, B6 XY(POS) fetuses develop ovaries and ovotestes and B6 XY(AKR) fetuses have delayed testis cord development. To test whether abnormal testis development is caused by insufficient Sry(DOM) expression, two approaches were used. First, gonad development and relative Sry expression levels were examined in fetal gonads from two strains of B6 mice that contained a single M. domesticus-derived and a single M. musculus-derived Sry allele (B6-Y(POS,RIII) and B6-Y(AKR,RIII)). In both cases, presence of the M. musculus Sry(RIII) allele corrected abnormal testis development. On the B6 background, Sry(POS) was expressed at about half the level of Sry(RIII) whereas Sry(AKR) and Sry(RIII) were equally expressed. On an F(1) hybrid background, both Sry(POS) and Sry(RIII) expression increased, but Sry(POS) expression increased to a greater extent. Second, sexual development and Sry expression levels were determined in XX mice carrying a transgene expressing Sry(POS) controlled by POS-derived or MUS-derived regulatory regions. In both cases one B6 transgenic line was recovered in which XX transgenic mice developed only testicular tissue but cord development was delayed despite normal Sry transcriptional initiation and overexpression. For three transgenes where B6 XX transgenic mice developed as females, hermaphrodites, or males, the percentage of XX transgenic males increased on an F(1) background. For the one transgene examined, Sry expression increased on an F(1) background. These results support a model in which delayed testis development is caused by the presence of particular DOM SRY protein isoforms and this, combined with insufficient Sry expression, causes sex reversal. These results also indicate that at least one tda gene regulates Sry expression, possibly by directly binding to Sry regulatory regions.