Miracle-dz/UniFAR-FTUs huggingface dataset:
A hand‐held optical coherence tomography angiography scanner based on angiography reconstruction transformer networks

Optical coherence tomography angiography (OCTA) has successfully demonstrated its viability for clinical applications in dermatology. Due to the high optical scattering property of skin, extracting high‐quality OCTA images from skin tissues requires at least six‐repeated scans. While the motion artifacts from the patient and the free hand‐held probe can lead to a low‐quality OCTA image. Our deep‐learning‐based scan pipeline enables fast and high‐quality OCTA imaging with 0.3‐s data acquisition. We utilize a fast scanning protocol with a 60 μm/pixel spatial interval rate and introduce angiography‐reconstruction‐transformer (ART) for 4× super‐resolution of low transverse resolution OCTA images. The ART outperforms state‐of‐the‐art networks in OCTA image super‐resolution and provides a lighter network size. ART can restore microvessels while reducing the processing time by 85%, and maintaining improvements in structural similarity and peak‐signal‐to‐noise ratio. This study represents that ART can achieve fast and flexible skin OCTA imaging while maintaining image quality.
Double-flanged knotless technique for iris prosthesis and IOL implantation associated with keratoplasty

Introduction Anterior segment reconstruction and penetrating keratoplasty combined with iris prosthesis (IP) and intraocular lens (IOL) scleral fixation require prolonged open-sky surgery and complex suturing. Herein we present a novel double-flanged knotless surgical technique that minimizes the open sky duration and facilitates the fixation of the IP and IOL complex to the sclera. Methods After corneal trephination and removal, a temporary keratoprosthesis is fixated. Three 5.0 polypropylene suture segments are introduced in the anterior chamber transconjunctivally and then externalized through keratoprosthesis. Each suture is threaded through the eyelets of the IP and then flanged. The temporary keratoprosthesis is removed, and the IP and IOL complex is positioned in the sulcus. A donor cornea button is sutured in place and the IP is centred on the optical axis by adjusting the polypropylene sutures. Finally, the suture ends are shortened, flanged, and buried under the conjunctiva. Results Surgery was performed on three eyes of three patients. No intraoperative complications occurred, while cystoid macular edema and ocular hypertension occurred in two patients during the follow-up period. The best corrected visual acuity was 6/20, 8/20, and 13/20. So far the IPs remained stable in the three eyes with a maximum follow-up of 18 months. Conclusion This novel technique of penetrating keratoplasty combined with an intraocular lens (IOL) and iris prosthesis implantation makes it possible to reduce open sky surgery time, avoid complex suturing, and ensure optimal IOL visual axis alignment by adjusting suture tension.
The effect of the cortical bone trajectory screw fixation and traditional pedicle screw fixation on surgical site wound infection in posterior lumbar fusion wound: A meta‐analysis

A meta‐analysis investigation was performed to measure the influence of cortical bone trajectory screw fixation (CBTSF) and traditional pedicle screw fixation (TPSF) on surgical site wound infection (SSWI) in posterior lumbar fusion (PLF). A comprehensive literature inspection till February 2023 was applied and 1657 interrelated investigations were reviewed. The 13 chosen investigations enclosed 1195 individuals with PLF in the chosen investigations' starting point, 578 of them were using CBTSF, and 617 were using TPSF. Odds ratio (OR) in addition to 95% confidence intervals (CIs) were utilised to compute the value of the effect of the CBTSF and TPSF on SSWI in PLF by the dichotomous approaches and a fixed or random model. No significant difference was found between individuals using CBTSF and TPSF in SSWI (OR, 0.68; 95% CI, 0.35–1.33, P = .26), superficial SSWI (OR, 0.62; 95% CI, 0.22–1.79, P = .38), and deep SSWI (OR, 0.30; 95% CI, 0.06–1.50, P = .14) in PLF. No significant difference was found between individuals using CBTSF and TPSF in SSWI, superficial SSWI, and deep SSWI in PLF. However, care must be exercised when dealing with its values because of the small sample sizes of several chosen investigations for this meta‐analysis and the low number of selected investigations for a certain type of SSWI.
One health surveillance strategy for coronaviruses in Italian wildlife

Abstract The recent reinforcement of CoV surveillance in animals fuelled by the COVID-19 pandemic provided increasing evidence that mammals other than bats might hide further diversity and play critical roles in human infectious diseases. This work describes the results of a two-year survey carried out in Italy with the double objective of uncovering CoV diversity associated with wildlife and of excluding the establishment of a reservoir for SARS-CoV-2 in particularly susceptible or exposed species. The survey targeted hosts from five different orders and was harmonised across the country in terms of sample size, target tissues, and molecular test. Results showed the circulation of 8 CoV species in 13 hosts out of the 42 screened. Coronaviruses were either typical of the host species/genus or normally associated with their domestic counterpart. Two novel viruses likely belonging to a novel CoV genus were found in mustelids. All samples were negative for SARS-CoV-2, with minimum detectable prevalence ranging between 0.49% and 4.78% in the 13 species reaching our threshold sample size of 59 individuals. Considering that within-species transmission in white-tailed deer resulted in raising the prevalence from 5% to 81% within a few months, this result would exclude a sustained cycle after spillback in the tested species.
A Search for Squarks and Gluinos with the CMS Detector

A search for squarks and gluinos is conducted, using the Compact Muon Solenoid detector at the Large Madron Collider, in events containing energetic jets and j.,, ' inissing euergy. Analyzed are 1.1/11) of data collected (hiring the 2011 run at 7 TeV. Backgrounds from the mis-measurement of known pro­ cesses are strongly suppressed using a novel kinematic variable, and the rates of the remaining backgrounds are estimated using control samples. The data are found to agree with expectations from the Standard Model. The results are interpreted within the Constrained Minimal Supersyniniet ric Standard Model, where equal squark and gluino masses below 1.1 TeV are excluded at 95% confidence level. The results are also interpreted within sim­ plified supersyinniet.ric 1 Is. for which upper limits on the production cross sections are determined as functions of the super-partner particle masses.
Network pharmacology and molecular docking to explore the pharmacological mechanism of Yifei Tongluo granules in treating idiopathic pulmonary fibrosis: A review

Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease that leads to progressive dyspnea and dry cough, with extracellular matrix deposition as the main pathological feature. Yifei Tongluo granules (YTG) are a traditional Chinese medicine formula that could nourish Qi-Yin, clear phlegm, and invigorate blood circulation. In this research, network pharmacology and molecular docking were used to elucidate the potential mechanism of YTG for treating IPF. A total of 278 biologically active compounds were included in YTG, and 16 compounds were selected for pharmacological analysis and molecular docking through “drugs-compounds-intersecting targets of YTG and IPF” network construction. Protein-protein interaction network was constructed using 330 YTG-IPF intersecting targets. Furthermore, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were performed. A total of 10 core targets were screened by protein-protein interaction, and molecular docking was used to further validate the binding ability of the compounds to the core targets. The network pharmacology and molecular docking results showed that Danshenol A, isorhamnetin, Ginsenoside-Rh4, quercetin, and kaempferol might be the main active compounds in the treatment of IPF by YTG, whereas MAPK1, MAPK3, EGFR, and SRC are the core targets while PI3K/AKT pathway and MAPK pathway are the main signaling pathways through which YTG regulates relevant biological processes to intervene in IPF. This study shows that YTG can treat IPF by inhibiting the epithelial-mesenchymal transit process, fibroblast proliferation, fibroblast-to-myofibroblast conversion, myofibroblast anti-apoptosis, collagen expression, and other mechanisms.YTG can be widely used as an adjuvant therapy for IPF in clinical practice, and this study provides the basis for subsequent experimental studies.
Systemic lupus erythematosus and toll-like receptor 9 polymorphisms: A meta-analysis of genetic association studies

Objective This study aimed to examine whether polymorphisms in toll-like receptor 9 (TLR9) contribute to vulnerability to systemic lupus erythematosus (SLE). Methods We searched the MEDLINE, Embase, and Web of Science databases for relevant articles. We conducted a meta-analysis to examine the association between the TLR9 rs187084, rs352139, rs352140, and rs5743836 polymorphisms and SLE risk. Results A total of 5447 patients with SLE and 6588 control participants across 26 trials from 24 articles were included. The TLR9 rs187084 T allele was significantly associated with SLE (odds ratio, 1.146; 95% confidence interval, 1.033–1.273; p = 0.010). In a meta-analysis, the TLR9 rs187084 T allele was associated with SLE in the Asian population but not in the Arab population, demonstrating the existence of ethnicity-specific effects. Using homozygote contrast and recessive models, the researchers also found that the TLR9 rs187084 T/C polymorphism was associated with SLE. The TLR9 rs352139 G allele was not associated with SLE in this meta-analysis. After accounting for ethnic differences, we found that the TLR9 rs352139 G allele was not associated with SLE in Asians and Arabs. Furthermore, homozygote contrast and dominant models found no association between the TLR9 rs352139 G/A polymorphism and SLE. TLR9 polymorphisms at rs352140 and rs5743836 were not associated with an increased risk of SLE in any genetic prediction model, including people of Asian, European, or Latin American ancestry. Conclusions SLE susceptibility is associated with the TLR9 rs187084 polymorphism in the Asian population and the rs187084, rs352139, rs352140, and rs5743836 polymorphisms in the Asian, European, and Latin American populations, respectively.
Quantitative Computed Tomography Analysis of the Longitudinal Change Between Centrilobular and Paraseptal Emphysema Subtypes: A Retrospective Study

Objective This study aimed to investigate the difference between the extent of centrilobular emphysema (CLE) and paraseptal emphysema (PSE) on follow-up chest CT scans and their relationship to the cross-sectional area (CSA) of small pulmonary vessels. Methods Sixty-two patients (36 CLE and 26 PSE) who underwent 2 chest CT scans were enrolled in this study. The percentage of low attenuation volume (%LAV) and total CSA of the small pulmonary vessels <5 mm2 (%CSA < 5) were measured at the 2 time points. Analysis of the initial %CSA < 5 and the change in the %LAV and %CSA < 5 on follow-up imaging was performed. Results The initial %CSA < 5 was not significantly different between the CLE and the PSE groups (CLE, 0.66 vs. PSE, 0.71; P = 0.78). There was no significant difference in the longitudinal change in the %LAV between the 2 groups (CLE, −0.048% vs. PSE, 0.005%; P = 0.26). The longitudinal change in the %CSA < 5 in patients with PSE significantly decreased compared with those with CLE (CLE, 0.025% vs. PSE, −0.018%; P = 0.02). Conclusions The longitudinal change in the %CSA < 5 was significantly different for patients with CLE and PSE, demonstrating an important pathophysiological difference between the subtypes.
Multi-pulse dynamic patterns in a mode-locked erbium-doped fiber laser based on an Sb2S3-PVA saturable absorber

Multi-pulse dynamic patterns have been experimentally documented in a passively mode-locked (PML) erbium-doped fiber (EDF) laser using an Sb2S3-PVA saturable absorber (SA). The fundamental mode-locking operation, with a repetition rate of ∼3.22 MHz, a pulse width of ∼2.5 ps, a signal-to-noise ratio (SNR) of ∼50 dB and a peak power over 200 W, was achieved under a pump power from 280 to 360 mW with appropriate polarization states introduced by the polarization controllers (PCs). By rotating the orientation of the intra-cavity PCs carefully and slowly at a pump power of 350 mW, it was found that a multi-pulse bunch was transformed gradually from a single-pulse to a twelve-pulse bunch, with several intermediate transition states of multi-pulse bunches being observed. In addition, other characteristic modes including disordered multi-pulses and soliton rains have been experimentally observed by meticulously adjusting the polarization states of PCs at a pump power of 350 mW. Our systematic study clearly demonstrates that Sb2S3 has potential as an effective SA for generating different operation states of multi-pulses in PML anomalous-dispersion EDF lasers.
Development of screening assays for use of broadly neutralizing antibodies in people with HIV

Purpose of review Treatment with combinations of complementary broadly neutralizing antibodies (bnAbs) has increased the proportion of participants for whom bnAbs can maintain virus suppression upon cessation of antiretroviral therapy (ART). There remains, however, a population of trial participants who experience virus rebound despite high plasma concentrations of bnAbs. Thus, baseline resistance remains a critical barrier to the efficacy of bnAbs for use in the treatment and cure of HIV, and the development of a screening assay to guide bnAb selection is a high priority. Recent findings There are two conceptual approaches to assess the putative rebound-competent HIV-1 reservoir for bnAb sensitivity: to assess neutralization sensitivity of reactivated virus in outgrowth assays and sequence-based approaches that include a selection for intact genomes and assessment of known resistance mutations within the env gene. Currently, the only phenotypic assay for bnAb screening that is clinical laboratory improvement amendments certified (CLIA certified) and available for clinical trial use is Monogram Biosciences’ PhenoSense HIV Neutralizing Antibody Assay. Summary Several new approaches for screening are currently under development and future screening methods must address three issues. First, complete sampling of the reservoir may be impossible, and determination of the relevance of partial sampling is needed. Second, multiple lines of evidence indicate that in vitro neutralization measures are at least one correlate of in vivo bnAb activity that should be included in screening, but more research is needed on how to use in vitro neutralization assays and other measures of antibody functions and measures of other antibody features. Third, the feasibility of screening assays must be a priority. A feasible, predictive bnAb screening assay will remain relevant until a time when bnAb combinations are substantially more broad and potent.
BL-Functions and Free BL-Algebra

Fuzzy logics are designed to support logical inferences on vague or uncertain premises, and they are useful in several theoretical and applicative areas of computer science. A central paradigm in mathematical fuzzy logic, popularized by Hajek [Haj98], is based on the idea of weakening Boolean logic starting from a suitable generalization of Boolean conjunction, namely, a class of [0, 1]-valued binary functions known as (continuous) triangular norms. Any continuous triangular norm gives raise to a propositional logic, and Hajek’s Basic fuzzy logic (for short, Basic logic) is the intersecting common fragment of all these logics. Despite the intensive research efforts devoted to Basic logic in the last decade, this logic still resists to a complete understanding, as it appears from the lack of a satisfactory proof theory [MOG]. The algebraic counterpart of Basic logic is given by a very natural subvariety of residuated bounded lattices, namely commutative, divisible and prelinear residuated lattices, or BL-algebras. A representation result of Agliano and Montagna [AM03] establishes that the variety generated by all the n-generated BL-algebras is singly generated by the BL-chain (n + 1)[0, 1], given by the ordinal sum of n + 1 copies of the generic MV-chain [0, 1]. As a consequence, validity problems in Basic logic turn out to have the same computational complexity of their Boolean counterparts [BHMV02, BM08]. This fact provides further motivation for the investigation of Basic logic in the computer science setting. The aforementioned result of Agliano and Montagna is the starting point of this thesis. By universal algebra, it gives an implicit functional representation of the free n-generated BL-algebra: the free n-generated BL-algebra is isomorphic to the clone of n-ary term operations of (n + 1)[0, 1], with the basic operations defined pointwise. Hence, to provide an explicit functional representation of the free n-generated BL-algebra, it is sufficient to describe exactly the subset of n-ary functions over the domain of (n + 1)[0, 1] that contains all projections and is closed under the basic operations of (n + 1)[0, 1]: we call these functions, n-ary BLfunctions. By algebraic logic, the Lindenbaum-Tarski algebra of the nvariate fragment of Basic logic is isomorphic to the free BL-algebra over n generators, thus n-ary BL-functions coincide with the truthfunctions of the n-variate fragment of Basic logic. The main contribution of this thesis is the explicit representation of the free n-generated BL-algebra in terms of n-ary BL-functions. Our result accounts as the BL-algebraic counterpart of Mundici’s constructive version of the McNaughton theorem for MV-algebras [Mun94], and improves the previous knowledge on the subject, that was limited to the case of one generator settled by Montagna [Mon00] and Aguzzoli and Gerla [AG05].
Association between alcoholic beverage intake and hyperuricemia in Chinese adults: Findings from the China Health and Nutrition Survey

While prior research has shown that consuming alcohol may raise the risk of hyperuricemia, little is known about how individual types of alcohol are linked to levels of uric acid in China. Therefore, this study aimed to investigate the independent impact of beer, wine, and liquor on serum uric acid (SUA) levels in the serum of Chinese adults. This study analyzed data from the 2009 China Health and Nutrition Survey and included 7083 participants (3418 men and 3665 women, ≥18 years of age). Multivariable logistic regression was used to analyze the potential association between alcohol intake and hyperuricemia risk, while linear regression analysis and general linear model were performed to examine the impact of alcohol consumption on SUA levels. This study revealed that men who drank alcohol daily had a greater odds ratio (1.68, 95% confidence interval: 1.01, 2.81) of hyperuricemia than those who drank alcohol no more than once a month. SUA levels of men significantly increased by 0.001 mg/dL for per additional gram of liquor consumed weekly. But men who drank ≤ 90.6 g of liquor per week had lower SUA levels compared with those in nondrinkers. SUA levels were inversely associated with wine intake in women (P = .03, P for trend = .02). Overall, consumption of beer, wine, and liquor differentially affected SUA levels in adult Chinese men and women.
Decoupling: adaptation of a treatment for body-focused repetitive behaviour to Tourette syndrome. A case report

Abstract Aims: Tourette syndrome (TS) is a neurological condition; its etiology is not yet fully understood. Cognitive behavioural therapy with habit reversal training is the recommended first-line treatment, but is not effective in all patients. This is the first report examining the usefulness of decoupling, a behavioural self-help treatment originally developed for patients with body-focused repetitive behaviours, in a patient with TS. Method: Patient P.Z. showed 10 motor and three vocal tics on the Adult Tic Questionnaire (ATQ) before treatment. He was taught decoupling by the first author. Results: The application of decoupling led to a reduction of P.Z. ’s eye tics, which was one of his first and most enduring and severe tics. It was not effective for other areas. Quality of life and depression improved, which P.Z. attributed to the improvement of his tics. Conclusion: Decoupling may be adopted as an alternative, when habit reversal training is not feasible. Future research, preferably using a controlled design with a large sample, may elucidate whether decoupling is only effective for tics relating to the eyes, the most common symptom in tic disorder/TS, or whether its effects extend to other symptoms.
Different Electrophysiological Signatures of Similarity-induced and Stroop-like Interference in Language Production

Abstract Contextual similarity between targets and competitors, whether semantic or phonological, often leads to behavioral interference in language production. It has been assumed that resolving such interference relies on control processes similar to those involved in tasks such as Stroop. This article tests this assumption by comparing the electrophysiological signatures of interference resulting from a contextual similarity versus a Stroop-like manipulation. In blocks containing two items, participants repeatedly named pictures that were semantically related, phonologically related, or unrelated (contextual similarity manipulation). In straight blocks, the pictures were named by their canonical names. In reverse blocks, participants had to reverse the names (Stroop-like manipulation). Both manipulations led to behavioral interference, but with different electrophysiological profiles. Whole-scalp stimulus-locked and response-locked analyses of semantic and phonological similarity pointed to a system with global modularity with some degree of cascading and interactivity, whereas the effect of phase reversal was sustained and of the opposite polarity. More strikingly, a representational similarity analysis showed a biphasic pattern for Stroop-like reversal, with earlier higher similarity scores for the reverse phase flipping into lower scores ~500 msec poststimulus onset. In contrast, contextual similarity induced higher similarity scores up to articulation. Finally, response-locked mediofrontal components indexing performance monitoring differed between manipulations. Correct response negativity's amplitude was lower in the phonological blocks, whereas a pre-correct response negativity component had higher amplitude in reverse versus straight blocks. These results argue against the involvement of Stroop-like control mechanisms in resolving interference from contextual similarity in language production.
Large‐Scale Analysis of Meniscus Morphology as Risk Factor for Knee Osteoarthritis

Although it is established that structural damage of the meniscus is linked to knee osteoarthritis (OA) progression, the predisposition to future development of OA because of geometric meniscal shapes is plausible and unexplored. This study aims to identify common variations in meniscal shape and determine their relationships to tissue morphology, OA onset, and longitudinal changes in cartilage thickness.