Miracle-dz/UniFAR-FTUs huggingface dataset:
Patterns of Alcohol Consumption and Fetal Development

Effects of heavy, moderate, and rare alcohol consumption on fetal development were analyzed in a prospective study of 469 mother-infant pairs. Differential effects of heavy drinking in early and late gestation were evaluated by separate analysis of neonates born to women who reduced consumption before the third trimester. Using x2 analysis, multiple regression, and matched sets, statistically significant associations (P<.01) were observed between sustained heavy drinking and both intrauterine growth retardation and congenital anomalies. These associations were independent of eight other risk factors. No differences were observed between offspring of rare and moderate drinkers. Infants born to women who reduced heavy drinking did not differ in growth from offspring of rare and moderate drinkers but demonstrated a higher frequency of abnormalities. Sustained heavy drinking represents a major risk; reduction in midpregnancy can benefit the newborn. Identification and therapy of heavy drinking are important components of prenatal care.
Vacuum polarization of scalar and spinor fields near closed null geodesics.

Hawking has recently proposed a ``chronology protection conjecture,'' which states that closed timelike curves cannot form in the real Universe. The most likely mechanism for enforcing this conjecture, if it is correct, is a divergent vacuum polarization at the Cauchy horizon (``chronology horizon'') where closed timelike curves first try to form. Hawking has proved that, if the chronology horizon is compactly generated, then it contains one or more smoothly closed null geodesics. Because it seems likely that all the horizon's generators emerge from these closed null geodesics, a sufficiently strongly divergent vacuum polarization at the closed null geodesics is likely to destroy the chronology horizon completely and thereby prevent closed timelike curves from forming. In this paper we compute the details of the divergence near the closed null geodesics, in a generic spacetime with a compactly generated chronology horizon\char22{}thereby generalizing earlier computations, in special spacetimes, by Hiscock and Konkowski, Kim and Thorne, and Frolov. We carry out the computation for both a conformal scalar field and a two-component spinor field. We show that, for an observer who will pass through a point on the closed null geodesic after a small interval of proper time \ensuremath{\delta}t, the leading-order divergence is always proportional to (\ensuremath{\delta}t${)}^{\mathrm{\ensuremath{-}}3}$ and has the same tensorial structure as the stress-energy of a null fluid moving along the closed null geodesic. We also show that, by contrast with flat spacetime, there is in general no cancellation between the divergent vacuum energies of a combination of fields that, in flat spacetime, would be related by supersymmetry: two conformal scalar fields and one two-component spinor field. We discuss the implications of these results for Hawking's chronology protection conjecture.
Clinical review: Controversies regarding transdermal androgen therapy in postmenopausal women.

CONTEXT Recently, the field of androgen therapy in postmenopausal women has received much attention and press. Although the ovary ceases to produce follicles and estrogen at menopause, it continues to produce androgens. Hence, many oophorectomized women complain of sexual dysfunction (despite adequate estrogenization). Previous studies of nontransdermal testosterone replacement have shown an improvement in libido and sexual frequency, although at the cost of supraphysiological testosterone levels. Transdermal testosterone patch (Intrinsa) was developed to deliver a physiological amount of testosterone. In 2004, the Food and Drug Administration voted not to approve Intrinsa until long-term safety data are available. EVIDENCE ACQUISITION Recent trials of Intrinsa in postmenopausal women were included. A MEDLINE search was conducted for articles published over the last 40 yr based on the key words androgen therapy/replacement and postmenopausal women. Relevant placebo-controlled trials of nontransdermal androgen therapy in postmenopausal women were also reviewed. EVIDENCE SYNTHESIS Early results from industry-funded trials show that transdermal testosterone therapy results in only moderate (although statistically significant) improvement in libido in surgically menopausal women (on estrogen). However, the published data are of short duration (24 wk). Hence, long-term safety in these women remains unclear. CONCLUSION We recommend a short-term trial (not to exceed 24 wk) of transdermal testosterone therapy (once approved) in surgically menopausal (estrogenized) women with distressful sexual dysfunction. Until the patch gets approval, a short trial of oral methyltestosterone in deserving estrogenized women may be justified.
Healthcare-Associated Pneumonia: Don't Forget About Respiratory Viruses!

Introduction: Healthcare-associated infections are an important cause of morbidity and mortality, are among the most common adverse events in healthcare, and of them, pneumonia is the most commonly reported. Our objective was to evaluate the incidence and clinical outcome of respiratory viruses in hospital-acquired pneumonia (HAP). Methods: This was a prospective cohort study, include patients aged between 0 and 18 who fulfilled Centers for Diseases Control and Prevention (CDC) criteria for HAP. Demographic and clinical data were obtained, and a nasopharyngeal swab specimen was taken for the detection of respiratory viruses. All included patients were monitored until discharge to collect data on the need for mechanical ventilation, intensive care unit (ICU) admission, and mortality. All-cause 30-day mortality was also ascertained. Results: Four thousand three hundred twenty-seven patients were followed for 42,658 patient-days and 5,150 ventilator-days. Eighty-eight patients (2.03%) met the CDC criteria for HAP, 63 patients were included, and clinical and epidemiological characteristics showed no statistically significant differences between patients with virus associated healthcare-associated pneumonia (VAHAP) and those with non-viral healthcare-associated pneumonia (NVHAP). At least one respiratory virus was detected in 65% [95% CI (53–77)] of episodes of HAP, with a single viral pathogen observed in 53.9% and coinfection with 2 viruses in 11.1% of cases. The outcome in terms of ICU admission, mechanical ventilation and the 30-day mortality did not show a significant difference between groups. Conclusions: In two-thirds of the patients a respiratory virus was identified. There was no difference in mortality or the rest of the clinical outcome variables. About half of the patients required mechanical ventilation and 10% died, which emphasizes the importance of considering these pathogens in nosocomial infections, since their identification can influence the decrease in hospital costs and be taken into account in infection control policies.
Evidence for a cysteine-mediated mechanism of excitation energy regulation in a photosynthetic antenna complex

Significance All photosynthetic organisms face the challenge of absorbing solar energy and regulating its flow through their light-harvesting antennas across widely varying photic conditions. For anoxygenic phototrophs, this process is complicated by the need to downregulate photosynthetic output when oxygen is encountered. The Fenna–Matthews–Olson protein from green sulfur bacteria is able to quench excitations in aerobic conditions effectively despite its apparent lack of photoprotective accessory molecules, indicating a previously unidentified type of energy transfer regulation. In this study, we provide evidence for a novel energy-quenching mechanism involving cysteine–bacteriochlorophyll photochemistry. This interaction should be able to be programed into other natural or bio-inspired antennas, opening new possibilities for regulating these systems in response to excess light. Light-harvesting antenna complexes not only aid in the capture of solar energy for photosynthesis, but regulate the quantity of transferred energy as well. Light-harvesting regulation is important for protecting reaction center complexes from overexcitation, generation of reactive oxygen species, and metabolic overload. Usually, this regulation is controlled by the association of light-harvesting antennas with accessory quenchers such as carotenoids. One antenna complex, the Fenna–Matthews–Olson (FMO) antenna protein from green sulfur bacteria, completely lacks carotenoids and other known accessory quenchers. Nonetheless, the FMO protein is able to quench energy transfer in aerobic conditions effectively, indicating a previously unidentified type of regulatory mechanism. Through de novo sequencing MS, chemical modification, and mutagenesis, we have pinpointed the source of the quenching action to cysteine residues (Cys49 and Cys353) situated near two low-energy bacteriochlorophylls in the FMO protein from Chlorobaculum tepidum. Removal of these cysteines (particularly removal of the completely conserved Cys353) through N-ethylmaleimide modification or mutagenesis to alanine abolishes the aerobic quenching effect. Electrochemical analysis and electron paramagnetic resonance spectra suggest that in aerobic conditions the cysteine thiols are converted to thiyl radicals which then are capable of quenching bacteriochlorophyll excited states through electron transfer photochemistry. This simple mechanism has implications for the design of bio-inspired light-harvesting antennas and the redesign of natural photosynthetic systems.
A Distance-Based Kernel Association Test Based on the Generalized Linear Mixed Model for Correlated Microbiome Studies

Researchers have increasingly employed family-based or longitudinal study designs to survey the roles of the human microbiota on diverse host traits of interest (e. g., health/disease status, medical intervention, behavioral/environmental factor). Such study designs are useful to properly control for potential confounders or the sensitive changes in microbial composition and host traits. However, downstream data analysis is challenging because the measurements within clusters (e.g., families, subjects including repeated measures) tend to be correlated so that statistical methods based on the independence assumption cannot be used. For the correlated microbiome studies, a distance-based kernel association test based on the linear mixed model, namely, correlated sequence kernel association test (cSKAT), has recently been introduced. cSKAT models the microbial community using an ecological distance (e.g., Jaccard/Bray-Curtis dissimilarity, unique fraction distance), and then tests its association with a host trait. Similar to prior distance-based kernel association tests (e.g., microbiome regression-based kernel association test), the use of ecological distances gives a high power to cSKAT. However, cSKAT is limited to handling Gaussian traits [e.g., body mass index (BMI)] and a single chosen distance measure at a time. The power of cSKAT differs a lot by which distance measure is used. However, choosing an optimal distance measure is challenging because of the unknown nature of the true association. Here, we introduce a distance-based kernel association test based on the generalized linear mixed model (GLMM), namely, GLMM-MiRKAT, to handle diverse types of traits, such as Gaussian (e.g., BMI), Binomial (e.g., disease status, treatment/placebo) or Poisson (e.g., number of tumors/treatments) traits. We further propose a data-driven adaptive test of GLMM-MiRKAT, namely, aGLMM-MiRKAT, so as to avoid the need to choose the optimal distance measure. Our extensive simulations demonstrate that aGLMM-MiRKAT is robustly powerful while correctly controlling type I error rates. We apply aGLMM-MiRKAT to real familial and longitudinal microbiome data, where we discover significant disparity in microbial community composition by BMI status and the frequency of antibiotic use. In summary, aGLMM-MiRKAT is a useful analytical tool with its broad applicability to diverse types of traits, robust power and valid statistical inference.
Protocol for the development of a core indicator set for reporting burn wound infection in trials: ICon-B study

Introduction Systematic reviews of high-quality randomised controlled trials are necessary to identify effective interventions to impact burn wound infection (BWI) outcomes. Evidence synthesis requires that BWI is reported in a consistent manner. Cochrane reviews investigating interventions for burns report that the indicators used to diagnose BWI are variable or not described, indicating a need to standardise reporting. BWI is complex and diagnosed by clinician judgement, informed by patient-reported symptoms, clinical signs, serum markers of inflammation and bacteria in the wound. Indicators for reporting BWI should be important for diagnosis, frequently observed in patients with BWI and assessed as part of routine healthcare. A minimum (core) set of indicators of BWI, reported consistently, will facilitate evidence synthesis and support clinical decision-making. Aims The Infection Consensus in Burns study aims to identify a core indicator set for reporting the diagnosis of BWI in research studies. Methods (1) Evidence review: a systematic review of indicators used in trials and observational studies reporting BWI outcomes to identify a long list of candidate indicators; (2) refinement of the long list into a smaller set of survey questions with an expert steering group; (3) a two-round Delphi survey with 100 multidisciplinary expert stakeholders, to achieve consensus on a short list of indicators; (4) a consensus meeting with expert stakeholders to agree on the BWI core indicator set. Ethics and dissemination Participants will be recruited through professional bodies, such that ethical approval from the National Health Service (NHS) Health Research Authority (HRA) is not needed. The core indicator set will be disseminated through peer-reviewed publication, co-production with journal editors, research funders and professional bodies, and presentation at national conferences. PROSPERO registration number CRD42018096647.
Electrostatic model for an asymmetric combdrive

This paper presents an analytical solution to the electrostatic actuation of an asymmetric combdrive in out-of-plane and torsional motions. The exact solutions to force in the out-of-plane motion and the integral for torque in the torsional motion are obtained. The dependence of the peak force on the thickness of the movable fingers and the amount of overlap of the combs is given in closed form. Using our model, the shift of the natural resonant frequency due to a dc bias is analyzed. Furthermore, our solution also applies to the in-plane motion of an in-plane interdigitated combdrive. We found that an in-plane interdigitated combdrive generates a constant force within 0.1% when the minimum initial engagement length of the combs is twice the separation gap.
Solitary ileal bezoar: A rare cause of acute ileal obstruction in a teenager

Introduction: bezoars may be described as conglomerates of partially digested or indigestible organic substances in the gastrointestinal tract. bezoars are classified based on their composition. there are four main categories— phytobezoars, trichobezoars, pharmacobezoars, and lactobezoars. typically, bezoars are ingested and primarily conglomerate in the stomach over time. Occasionally, they may migrate distally and cause obstruction of small bowel. bezoar formation mainly occurs in patients with predisposing factors like altered gastrointestinal anatomy due previous surgery or impaired gastric motility. the presence of isolated bezoar in the small bowel without synchronous existence of primary gastric bezoar or any apparent predisposing factors for bezoar formation remains an exceedingly a rare presentation. case report: We hereby, report a case of isolated ileal bezoar causing acute small bowel obstruction in rather a healthy 15-year-old girl. conclusion: solitary bezoar induced ileal obstruction in a healthy teenager is a rarity occurrence. this report is, therefore, aimed at highlighting this atypical cause of small bowel obstruction in this age group and cautions clinicians in our environment that bezoars form an essential
Co-cultivation of Trichoderma asperellum GDFS1009 and Bacillus amyloliquefaciens 1841 Causes Differential Gene Expression and Improvement in the Wheat Growth and Biocontrol Activity

In an effort to balance the demands of plant growth promoting and biological control agents in a single product, the technology on the co-cultivation of two microbes, Trichoderma asperellum GDFS1009 and Bacillus amyloliquefaciens 1841 has been developed and demonstrated its effectiveness in synergistic interactions and its impact on the plant growth and biocontrol potential. In this study, optimization of T. asperellum and B. amyloliquefaciens growth in a single medium was carried out using response surface methodology (RSM). The optimal medium for enhanced growth was estimated as 2% yeast extract, 2% molasses and 2% corn gluten meal. T. asperellum evolved the complicated molecular mechanisms in the co-culture by the induction of BLR-1/BLR-2, VELVET, and NADPH oxidases genes. In performance with these genes, conserved signaling pathways, such as heterotrimeric G proteins and mitogen-activated protein kinases (MAPKs) had also involved in this molecular orchestration. The co-cultivation induced the expression of T. asperellum genes related to secondary metabolism, mycoparasitism, antioxidants and plant growth. On the other hand, the competition during co-cultivation induced the production of new compounds that are not detected in axenic cultures. In addition, the co-culture significantly enhanced the plant growth and protection against Fusarium graminearum. The present study demonstrated the potential of co-cultivation technology could be a used to grow the T. asperellum GDFS1009 and B. amyloliquefaciens 1841 synergistically to improve the production of mycoparasitism related enzymes, secondary metabolites, and plant growth promoting compounds to significantly enhance the plant growth and protection against plant pathogens.
MMOG ONTOLOGY: HOW TO BE A FICTIONAL ANTIREALIST LUDIC REALIST

Fictional antirealism in my usage is the metaphysical position that fictional objects like made-up characters in a story are unreal in the sense that they can never be talked about nonfictionally: they cannot be referred to, and they cannot be quantified over. According to this position we cannot make assertions about Sherlock Holmes, for instance, neither by referring to him by that name nor by denoting him with a definite description like ”the best known fictional character in Sir Arthur Conan Doyle’s stories. ” An attempt to designate an object as Sherlock Holmes is doomed to failure from the beginning because there is no such object, and then we will fail to make an assertion about him: whatever we say it can have no truth-value. We indulge in makebelieve again when we go into our reader’s experiences as literary critics.
Telomerase and Telomeres in Endometrial Cancer

Telomeres at the termini of human chromosomes are shortened with each round of cell division due to the “end replication problem” as well as oxidative stress. During carcinogenesis, cells acquire or retain mechanisms to maintain telomeres to avoid initiation of cellular senescence or apoptosis and halting cell division by critically short telomeres. The unique reverse transcriptase enzyme complex, telomerase, catalyzes the maintenance of telomeres but most human somatic cells do not have sufficient telomerase activity to prevent telomere shortening. Tissues with high and prolonged replicative potential demonstrate adequate cellular telomerase activity to prevent telomere erosion, and high telomerase activity appears to be a critical feature of most (80–90%) epithelial cancers, including endometrial cancer. Endometrial cancers regress in response to progesterone which is frequently used to treat advanced endometrial cancer. Endometrial telomerase is inhibited by progestogens and deciphering telomere and telomerase biology in endometrial cancer is therefore important, as targeting telomerase (a downstream target of progestogens) in endometrial cancer may provide novel and more effective therapeutic avenues. This review aims to examine the available evidence for the role and importance of telomere and telomerase biology in endometrial cancer.
The Way to Increase the Motor and Sport Competence Among Children: The Contextualized Sport Alphabetization Model

There is a concern to implement games that will be able to increase the students’ motor and sport competence during the sport contents in Physical Education. Some games encompassed in Models-Based Practice (MsBP) are more beneficial for physical and physiological development than others. The main purpose of this study is to compare the degree of physical and physiological performance in several futsal games that have been implemented through two MsBP: the Teaching Games for Understanding (TGfU) and the Contextualized Sport Alphabetization Model (CSAM). The second objective is to analyze the relationship between physical and physiological variables. A quasi-experimental and cross-sectional study with pre- and post-test evaluations had been carried out. The sample was composed of 112 Primary Education students from First to Sixth grade (9.35 ± 1.76 years). Polar Team Pro® technology was implemented to compare and analyze the physical and physiological variables. Data was analyze comparing both models with a two-step cluster model. Afterward, Student’s t-test was executed to compare the progression of both models. Besides, two-level multilevel model (MANOVA-ANOVA, followed by MANCOVA- ANCOVA) were also executed by means of applying a 4 versus 4 Small-Sided and Conditioned Game (SSCG). Finally, Pearson correlation between physical and physiological variables was calculated. Results showed that physical and physiological performance was higher in CSAM groups. In this regard, throughout the intervention of both models, results showed significant differences in physical and physiological variables at SSCGs implemented in the CSAM over the games implemented during the TGfU. Additionally, multilevel and MANCOVA post-test analyses shows significant differences in the physical and physiological performance during the post-test 4 vs. 4 SSCG at the CSAM students, in contrast to the TGfU students (p < 0.001). These results demonstrate that both physical (e.g., distance covered) and physiological performance (e.g., Edwards’ TRIMP) are significantly higher during CSAM in contrast to TGfU. Moreover, relationship between physical and physiological variables help teachers to adapt sessions to the features of the context.