Miracle-dz/UniFAR-FTUs huggingface dataset:
Diffusion-tensor imaging as an adjunct to dynamic contrast-enhanced MRI for improved accuracy of differential diagnosis between breast ductal carcinoma in situ and invasive breast carcinoma.

OBJECTIVE To determine the value of diffusion-tensor imaging (DTI) as an adjunct to dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for improved accuracy of differential diagnosis between breast ductal carcinoma in situ (DCIS) and invasive breast carcinoma (IBC). METHODS The MRI data of 63 patients pathologically confirmed as breast cancer were analyzed. The conventional MRI analysis metrics included enhancement style, initial enhancement characteristic, maximum slope of increase, time to peak, time signal intensity curve (TIC) pattern, and signal intensity on FS-T2WI. The values of apparent diffusion coefficient (ADC), directionally-averaged mean diffusivity (Davg), exponential attenuation (EA), fractional anisotropy (FA), volume ratio (VR) and relative anisotropy (RA) were calculated and compared between DCIS and IBC. Multivariate logistic regression was used to identify independent factors for distinguishing IBC and DCIS. The diagnostic performance of the diagnosis equation was evaluated using the receiver operating characteristic (ROC) curve. The diagnostic efficacies of DCE-MRI, DWI and DTI were compared independently or combined. RESULTS EA value, lesion enhancement style and TIC pattern were identified as independent factor for differential diagnosis of IBC and DCIS. The combination diagnosis showed higher diagnostic efficacy than a single use of DCE-MRI (P=0.02), and the area of the curve was improved from 0.84 (95% CI, 0.67-0.99) to 0.94 (95% CI, 0.85-1.00). CONCLUSIONS Quantitative DTI measurement as an adjunct to DCE-MRI could improve the diagnostic performance of differential diagnosis between DCIS and IBC compared to a single use of DCE-MRI.
Protocol for the Women And Their Children’s Health (WATCH) Study: A Cohort of Pregnancy and Beyond

Background The developmental origins of health and disease is a conceptual framework that helps explain the links between our early life exposures and later health outcomes, and is a burgeoning field of research. In this report, we describe the study protocol used in a prospective cohort of women recruited during pregnancy, with postnatal follow-up of the mothers and offspring. Methods The Women And Their Children’s Health (WATCH) cohort (n = 180 women) is being conducted at the John Hunter Hospital, Australia (from June 2006). Women attended study visits during pregnancy at 19, 24, 30, and 36 weeks’ gestation. Postnatal follow-up of the women and their offspring occurred at 3-month intervals during the first year after birth and annually thereafter, until age 4 years. Fetal ultrasound scans were performed at each pregnancy visit. Pregnancy and birth data were obtained from hospital records. Data collection has included maternal and child anthropometric, biochemical, dietary, physical activity, socioeconomic, medical, and other variables. Conclusions The 2 most novel components of our prospective cohort study are (1) the regular and systematic tracking of fetal and child growth and body composition, starting in the second trimester of pregnancy and continuing to age 4 years, and (2) the detailed maternal and child dietary data collection, including biochemical parameters. Detailed cohorts that collect data on the early nutritional, physiological, and social determinants of health are valuable. Despite its relatively small sample size, many hypotheses on developmental origins can be tested or piloted using data collected from the WATCH cohort.
FDA puts rosiglitazone post-marketing trial on hold

The US Food and Drugs Administration has suspended a post-marketing trial of the thiazolidinedione rosiglitazone while it looks at whether to withdraw the drug or keep it on the market. The thiazolidinedione intervention with vitamin D evaluation (TIDE) trial was designed to compare the cardiovascular safety of rosiglitazone (marketed as Avandia) and pioglitazone (Actos) in patients with type 2 diabetes. It was set up at the FDA’s request in 2007. The FDA has placed a “partial clinical hold” on the trial, which means that no new patients can be enrolled until further notice. Patients already enrolled in the trial will be allowed to continue. This follows the suspension by India’s drug controller general of the trial at the …
Colorectal cancer as a model for immunotherapy.

Colorectal cancer represents 10% of all cancers and 10% of cancer deaths in the United States with ∼130,000 new cases diagnosed annually [(1)][1] . There have been important advances in our understanding of the biology and genetics of this disease, and if diagnosed early, colorectal cancer is
Fast Transient Low-Dropout Voltage Regulator With Hybrid Dynamic Biasing Technique for SoC Application

This brief presents a low-dropout (LDO) voltage regulator without output capacitors that achieves fast transient responses by hybrid dynamic biasing. The hybrid dynamic biasing in the proposed transient improvement circuit is activated through capacitive coupling. The proposed circuit senses the LDO regulator output change so as to increase the bias current instantly. The proposed circuit was applied to an LDO regulator without output capacitors implemented in standard 0.35- μm CMOS technology. The device consumes only 25 μA of quiescent current with a dropout voltage of 180 mV. The proposed circuit reduces the output voltage spike of the LDO regulator to 80 mV when the output current is changed from 0 to 100 mA. The output voltage spike is reduced to 20 mV when the supply voltage varies between 1.3 and 2.3 V with a load current of 100 mA.
An enhanced treatment of hidden lines

A new display scheme is presented in which three-dimensional objects are represented with a much higher degree of user control of the line-drawing format than those in conventional schemes. In this scheme, the attribute of a line is determined not at the time of definition but after the viewing transformation has been applied, taking the shielding environment of the line into consideration. The essential difference between our scheme and conventional hidden-line removal/indication lies in the treatment of the shielding environment. In conventional hidden-line removal/indication, only the visible/invisible information is available for the selection of the attribute of a line. In our scheme, the entire set of surfaces that hide a line can be used to determine the attribute of the line. A much higher degree of freedom in generating pictures is achieved owing to the treatment of the shielding environment. We also describe a system called GRIP, which implements the new scheme.
Picoliter Drop-On-Demand Dispensing for Multiplex Liquid Cell Transmission Electron Microscopy

Abstract Liquid cell transmission electron microscopy (LCTEM) provides a unique insight into the dynamics of nanomaterials in solution. Controlling the addition of multiple solutions to the liquid cell remains a key hurdle in our ability to increase throughput and to study processes dependent on solution mixing including chemical reactions. Here, we report that a piezo dispensing technique allows for mixing of multiple solutions directly within the viewing area. This technique permits deposition of 50 pL droplets of various aqueous solutions onto the liquid cell window, before assembly of the cell in a fully controlled manner. This proof-of-concept study highlights the great potential of picoliter dispensing in combination with LCTEM for observing nanoparticle mixing in the solution phase and the creation of chemical gradients.
Using a validation model to measure the agility of software development in a large software development organization

This paper provides a metric for evaluating the agility of software development projects and organizations. The metric is based on a validation model derived from the V&V model. In this metric, agility is defined as minimizing the time between the production of intermediate deliverables and the validation of those deliverables. The major distinguishing feature of this metric is that it is independent of any particular software development process model, such as agile software development methods or the waterfall model. Therefore, this metric can be used for software development organizations that have a wide variety of software development projects with varying kinds of development processes. This metric has been shown to be practical in large software development organizations through exhaustive use in more than 7,000 projects over the last 9 years.
Sensitization of Glioblastoma Cells to Irradiation by Modulating the Glucose Metabolism

Because radiotherapy significantly increases median survival in patients with glioblastoma, the modulation of radiation resistance is of significant interest. High glycolytic states of tumor cells are known to correlate strongly with radioresistance; thus, the concept of metabolic targeting needs to be investigated in combination with radiotherapy. Metabolically, the elevated glycolysis in glioblastoma cells was observed postradiotherapy together with upregulated hypoxia-inducible factor (HIF)-1α and its target pyruvate dehydrogenase kinase 1 (PDK1). Dichloroacetate, a PDK inhibitor currently being used to treat lactic acidosis, can modify tumor metabolism by activating mitochondrial activity to force glycolytic tumor cells into oxidative phosphorylation. Dichloroacetate alone demonstrated modest antitumor effects in both in vitro and in vivo models of glioblastoma and has the ability to reverse the radiotherapy-induced glycolytic shift when given in combination. In vitro, an enhanced inhibition of clonogenicity of a panel of glioblastoma cells was observed when dichloroacetate was combined with radiotherapy. Further mechanistic investigation revealed that dichloroacetate sensitized glioblastoma cells to radiotherapy by inducing the cell-cycle arrest at the G2–M phase, reducing mitochondrial reserve capacity, and increasing the oxidative stress as well as DNA damage in glioblastoma cells together with radiotherapy. In vivo, the combinatorial treatment of dichloroacetate and radiotherapy improved the survival of orthotopic glioblastoma-bearing mice. In conclusion, this study provides the proof of concept that dichloroacetate can effectively sensitize glioblastoma cells to radiotherapy by modulating the metabolic state of tumor cells. These findings warrant further evaluation of the combination of dichloroacetate and radiotherapy in clinical trials. Mol Cancer Ther; 14(8); 1794–804. ©2015 AACR.
Central auditory processing disorder (CAPD) tests in a school-age hearing screening programme - analysis of 76,429 children.

INTRODUCTION AND OBJECTIVE Hearing disorders among school-age children are a current concern. Continuing studies have been performed in Poland since 2008, and on 2 December 2011 the EU Council adopted Conclusions on the Early Detection and Treatment of Communication Disorders in Children, Including the Use of e-Health Tools and innovative Solutions. The discussion now focuses not only on the efficacy of hearing screening programmes in schoolchildren, but what should be its general aim and what tests it should include? This paper makes the case that it is important to include central auditory processing disorder (CAPD) tests. One such test is the dichotic digits test (DDT). The aim of the presented study was to evaluate the usefulness of the DDT in detecting central hearing disorders in school-age children. MATERIALS AND METHODS During hearing screening programmes conducted in Poland in 2008-2010, exactly 235,664 children (7-12-years-old) were screened in 9,325 schools. Of this number, 7,642 were examined using the DDT test for CAPD. Screening programmes were conducted using the Sense Examination Platform. RESULTS With the cut-off criterion set at the 5th percentile, results for the DDT applied in a divided attention mode were 11.4% positive for 7-year-olds and 11.3% for 12-year-olds. In the focused attention mode, the comparable result for 12-year-olds was 9.7%. There was a clear right ear advantage. In children with positive DDT results, a higher incidence of other disorders, such as dyslexia, was observed. CONCLUSIONS A test for CAPD should be included in the hearing screening of school-age children. The results of this study form the basis for developing Polish standards in this area.
Verifiable computation using multiple provers

The increasing ubiquity of the cloud computing paradigm has renewed focus on the classical problem of allowing weak clients to check the results of computation delegated to powerful servers. Recent advances in proof-based verifiable computation have led to several near-practical protocols. Protocols based on interactive proofs (IPs) work with highly restrictive models of computation and are thus efficient only for a limited class of computations. In contrast, protocols based on argument systems apply to a much larger class of computations, but efficiency requires amortization of very expensive setup costs. This paper initiates the study of the practical efficiency of multiprover interactive proofs (MIPs). We present a new MIP for delegating computation that extends insights from a powerful IP protocol (Goldwasser et al., STOC, 2008). Without reductions or amplification, our protocol uses only two provers (departing from prior work on MIPs), and achieves both the efficiency of interactive proof-based protocols and the generality of argument system-based protocols. Also, this result, together with recently developed machinery, creates a potential avenue toward concretely efficient arguments without setup costs. We describe Clover, a built system for verifiable computation, based on our protocol. Although Clover does not implement the full theory (it has setup costs), it applies to problems that existing IPs cannot efficiently handle, and achieves performance comparable to, or better than, the best argument systems.
Building a Fast Ray Tracer

Ray tracing is often used in renderers, as it can create very high quality images at the expense of run time. It is useful because of its ability to solve many different problems in image rendering. Unless built efficiently, ray tracers take extreme lengths of time to complete their task. Optimizations are needed in order to keep the rendering time
The voltage dependence of the TMEM16B/anoctamin2 calcium-activated chloride channel is modified by mutations in the first putative intracellular loop

Ca2+-activated Cl− channels (CaCCs) are involved in several physiological processes. Recently, TMEM16A/anoctamin1 and TMEM16B/anoctamin2 have been shown to function as CaCCs, but very little information is available on the structure–function relations of these channels. TMEM16B is expressed in the cilia of olfactory sensory neurons, in microvilli of vomeronasal sensory neurons, and in the synaptic terminals of retinal photoreceptors. Here, we have performed the first site-directed mutagenesis study on TMEM16B to understand the molecular mechanisms of voltage and Ca2+ dependence. We have mutated amino acids in the first putative intracellular loop and measured the properties of the wild-type and mutant TMEM16B channels expressed in HEK 293T cells using the whole cell voltage-clamp technique in the presence of various intracellular Ca2+ concentrations. We mutated E367 into glutamine or deleted the five consecutive glutamates 386EEEEE390 and 399EYE401. The EYE deletion did not significantly modify the apparent Ca2+ dependence nor the voltage dependence of channel activation. E367Q and deletion of the five glutamates did not greatly affect the apparent Ca2+ affinity but modified the voltage dependence, shifting the conductance–voltage relations toward more positive voltages. These findings indicate that glutamates E367 and 386EEEEE390 in the first intracellular putative loop play an important role in the voltage dependence of TMEM16B, thus providing an initial structure–function study for this channel.
The linker domain of basal transcription factor TFIIB controls distinct recruitment and transcription stimulation functions

RNA polymerases (RNAPs) require basal transcription factors to assist them during transcription initiation. One of these factors, TFIIB, combines promoter recognition, recruitment of RNAP, promoter melting, start site selection and various post-initiation functions. The ability of 381 site-directed mutants in the TFIIB ‘linker domain’ to stimulate abortive transcription was systematically quantitated using promoter-independent dinucleotide extension assays. The results revealed two distinct clusters (mjTFIIB E78-R80 and mjTFIIB R90-G94, respectively) that were particularly sensitive to substitutions. In contrast, a short sequence (mjTFIIB A81-K89) between these two clusters tolerated radical single amino acid substitutions; short deletions in that region even caused a marked increase in the ability of TFIIB to stimulate abortive transcription (‘superstimulation’). The superstimulating activity did, however, not correlate with increased recruitment of the TFIIB/RNAP complex because substitutions in a particular residue (mjTFIIB K87) increased recruitment by more than 5-fold without affecting the rate of abortive transcript stimulation. Our work demonstrates that highly localized changes within the TFIIB linker have profound, yet surprisingly disconnected, effects on RNAP recruitment, TFIIB/RNAP complex stability and the rate of transcription initiation. The identification of superstimulating TFIIB variants reveals the existence of a previously unknown rate-limiting step acting on the earliest stages of gene expression.
A Modular Active Front-End Rectifier With Electronic Phase Shifting for Harmonic Mitigation in Motor Drive Applications

In this paper, an electronic phase-shifting strategy has been optimized for a multiparallel configuration of line-commutated rectifiers with a common dc-bus voltage used in motor drive application. This feature makes the performance of the system independent of the load profile and maximizes its harmonic reduction ability. In order to further reduce the generated low-order harmonics, a dc-link current modulation scheme and its phase-shift values of multidrive systems have been optimized. Analysis, simulations, and experiments have been carried out to verify the proposed method.
Understanding care farming as a swiftly developing sector in the Netherlands

Care farming or social farming is a swiftly developing sector across Europe. Care farms combine agricultural production with health and social services. The Netherlands is one of the leading countries in care farming. The aim of this study was to better understand how the new sector of care farming emerged so quickly in the Netherlands using basic concepts from transition theory´s multi-level perspective (MLP) as a canvas. The story is one of different types of care farms developing over time, starting with pioneering activities by entrepreneurial farmers and health care professionals in niche experiments, the creation of supportive regime structures by the care farming sector and regime changes that affected the development of the sector. In the pioneering phase, financing structures, legitimacy and support structures were lacking. After this pioneering period, support of ministries and. changes in the care regime created a fertile ground for fast growth. MLP was helpful in understanding how the regime changes came about, it however did not have sufficient conceptual tools to understand agency and had examined multi-system transitions to a limited extent only. Insights into entrepreneurship, institutional entrepreneurship and social movement theory helped to better understand agency in MLP. The transition across system boundaries posed additional challenges: separated sectors, a lack of legitimacy, a lack of embeddedness and having to deal with different logics. Actors who used their dual identity, actors combining entrepreneurial and institutional behavior and actors connecting with embedded actors with corresponding logics were important in overcoming these challenges.
Pathological Sprouting of Adult Nociceptors in Chronic Prostate Cancer-Induced Bone Pain

Pain frequently accompanies cancer. What remains unclear is why this pain frequently becomes more severe and difficult to control with disease progression. Here we test the hypothesis that with disease progression, sensory nerve fibers that innervate the tumor-bearing tissue undergo a pathological sprouting and reorganization, which in other nonmalignant pathologies has been shown to generate and maintain chronic pain. Injection of canine prostate cancer cells into mouse bone induces a remarkable sprouting of calcitonin gene-related peptide (CGRP+) and neurofilament 200 kDa (NF200+) sensory nerve fibers. Nearly all sensory nerve fibers that undergo sprouting also coexpress tropomyosin receptor kinase A (TrkA+). This ectopic sprouting occurs in sensory nerve fibers that are in close proximity to colonies of prostate cancer cells, tumor-associated stromal cells and newly formed woven bone, which together form sclerotic lesions that closely mirror the osteoblastic bone lesions induced by metastatic prostate tumors in humans. Preventive treatment with an antibody that sequesters nerve growth factor (NGF), administered when the pain and bone remodeling were first observed, blocks this ectopic sprouting and attenuates cancer pain. Interestingly, reverse transcription PCR analysis indicated that the prostate cancer cells themselves do not express detectable levels of mRNA coding for NGF. This suggests that the tumor-associated stromal cells express and release NGF, which drives the pathological reorganization of nearby TrkA+ sensory nerve fibers. Therapies that prevent this reorganization of sensory nerve fibers may provide insight into the evolving mechanisms that drive cancer pain and lead to more effective control of this chronic pain state.
Prototype of Instrument for Minimally Invasive Surgery with 6-Axis Force Sensing Capability

Minimally invasive surgery (MIS) challenges the surgeon’s skills due to his separation from the operation area which can only be reached with long instruments. To overcome these drawbacks, minimally invasive robotic surgery (MIRS) plays an important role. This paper describes the development of actuated and sensorized instruments for minimally invasive robotic surgery which help to increase the surgeon’s immersion and dexterity.
Distribute d power control for time varying wireless networks: Optimality and convergence

This paper presents a new distributed power control algorithm for ad-hoc wireless networks in random channel environments. Previous work in this area has focused on distributed power control for ad-hoc networks with ﬁxed channels. We show that the algorithms resulting from such formulations do not accurately capture the dynamics of a time-varying channel. The performance of the network, in terms of power consumption and generated interference, can be severely degraded when a power control algorithm designed for a deterministic channel is applied to a random channel. In particular, some well-known strong optimality results for deterministic channels no longer hold. In order to address these problems we propose a new criteria for power optimality in ad-hoc wireless networks. We then show that the optimal power allocation for this new criteria can be found through an appropriate stochastic approximation algorithm. Ultimately, the iterations of the stochastic approximation algorithm can be decoupled to form an optimal fully distributed on-line power control algorithm for ad-hoc wireless networks with time-varying channels.