Miracle-dz/UniFAR-FTUs huggingface dataset:
PERBEDAAN PSYCHOLOGICAL WELL-BEING REMAJA DITINJAU DARI PERSEPSI POLA ASUH ORANG TUA

Kondisi psychological well-being remaja perlu diperhatikan karena psychological well-being berhubungan dengan kemampuan resiliensi. Kemampuan resiliensi remaja yang buruk mengakibatkan beberapa masalah remaja seperti melakukan pencurian kendaraan bermotor, prostitusi online, konsumsi minuman keras dan obat-obatan terlarang. Kondisi Psychological well-being dipengaruhi oleh usia, tingkat pendidikan, kematangan emosi, kondisi ekonomi, dukungan sosial dan hubungan sosial. Salah satu bentuk hubungan sosial remaja adalah interaksi dengan orang tua (pola asuh). Pola asuh dibagi menjadi empat bentuk yaitu authoritative, authoritarian, indulgent dan neglectful. Jenis pola asuh ditentukan dari kualitas pemberian kehangatan dan kontrol orang tua pada remaja. Tujuan utama penelitian ini adalah melihat perbedaan kondisi psychological well-being ditinjau dari perbedaan persepsi gaya pola asuh orang tua. Metode yang digunakan dalam penelitian ini adalah metode penelitian kuantitatif dengan pengumpulan data menggunakan Skala Persepsi Pola Asuh (25 aitem, α = 0,894) dan Skala Psychological Well-being (38 aitem, α = 0,894). Partisipan penelitian adalah 180 siswa-siswi kelas 11 SMA Negeri 9 Semarang yang dipilih menggunakan teknik cluster sampling. Peneliti menemukan bahwa terdapat perbedaan signifikan kondisi psychological well-being ditinjau berdasarkan perbedaan persepsi pola asuh orang tua (p = 0,000.) tetapi tidak terdapat perbedaan signifikan antara kondisi psychological well-being remaja yang diasuh dengan pola asuh authoritative, authoritarian dan indulgent. Perbedaan kondisi psychological well-being yang signifikan ditunjukan oleh kelompok pola asuh neglectful.
AGO Recommendations for Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2013

vant decision making. According to ASCO-CAP guidelines, discordances for central versus local immunohistochemical staining of hormone receptors (HR) and human epidermal growth factor receptor 2 (HER2) are reported in about 20%, major discrepancies in grading for 40% [3–5]. Furthermore, in 2012, Mirror trialists reported an upgrade of 22% of pN0 cases to pN1 in central pathology [6]. In the context of these data, and because of the lack of consideration of HER2 overexpression as a prognostic and predictive factor, the AGO guidelines have downgraded the available version 8.0 of Adjuvant! online (LoE 2bB; AGO+/–). Considering immunohistochemical tumour markers, Ki-67 is a reliable prognostic factor especially after neoadjuvant chemotherapy (NACT)/ short-term endocrine treatment. Data for prediction of chemotherapy outcome are less convincing. The committee nevertheless recommends the clinical use of Ki-67 under the prerequisite of meticulous quality control (LoE 1aA; AGO+). As long as nationwide standardization and quality assurance are not implemented, cut-off levels cannot be reliably defined for routine use. uPA/PAI was tested in prospective trials and is suggested as a reliable prognostic marker and a predictive marker for the usefulness of chemotherapy in N0 cases (LoE 1aA; AGO+). New molecular tools (mRNA, DNA level) have the advantage of higher accuracy, reproducibility and lower interobserver variability compared to IHC. To allow for adequate evaluation of available molecular markers/genomic signatures, Introduction
The Host Range of Gammaretroviruses and Gammaretroviral Vectors Includes Post-Mitotic Neural Cells

Background Gammaretroviruses and gammaretroviral vectors, in contrast to lentiviruses and lentiviral vectors, are reported to be restricted in their ability to infect growth-arrested cells. The block to this restriction has never been clearly defined. The original assessment of the inability of gammaretroviruses and gammaretroviral vectors to infect growth-arrested cells was carried out using established cell lines that had been growth-arrested by chemical means, and has been generalized to neurons, which are post-mitotic. We re-examined the capability of gammaretroviruses and their derived vectors to efficiently infect terminally differentiated neuroendocrine cells and primary cortical neurons, a target of both experimental and therapeutic interest. Methodology/Principal Findings Using GFP expression as a marker for infection, we determined that both growth-arrested (NGF-differentiated) rat pheochromocytoma cells (PC12 cells) and primary rat cortical neurons could be efficiently transduced, and maintained long-term protein expression, after exposure to murine leukemia virus (MLV) and MLV-based retroviral vectors. Terminally differentiated PC12 cells transduced with a gammaretroviral vector encoding the anti-apoptotic protein Bcl-xL were protected from cell death induced by withdrawal of nerve growth factor (NGF), demonstrating gammaretroviral vector-mediated delivery and expression of genes at levels sufficient for therapeutic effect in non-dividing cells. Post-mitotic rat cortical neurons were also shown to be susceptible to transduction by murine replication-competent gammaretroviruses and gammaretroviral vectors. Conclusions/Significance These findings suggest that the host range of gammaretroviruses includes post-mitotic and other growth-arrested cells in mammals, and have implications for re-direction of gammaretroviral gene therapy to neurological disease.
THE JET HEATED X-RAY FILAMENT IN THE CENTAURUS A NORTHERN MIDDLE RADIO LOBE

We present results from a 40 ks XMM-Newton observation of the X-ray filament coincident with the southeast edge of the Centaurus A Northern Middle Radio Lobe (NML). We find that the X-ray filament consists of five spatially resolved X-ray knots embedded in a continuous diffuse bridge. The spectrum of each knot is well fitted by a thermal model with temperatures ranging from 0.3 to 0.7 keV and subsolar elemental abundances. In four of the five knots, nonthermal models are a poor fit to the spectra, conclusively ruling out synchrotron or IC/CMB mechanisms for their emission. The internal pressures of the knots exceed that of the ambient interstellar medium or the equipartition pressure of the NML by more than an order of magnitude, demonstrating that they must be short lived (∼3 × 106 yr). Based on energetic arguments, it is implausible that these knots have been ionized by the beamed flux from the active galactic nucleus of Cen A or that they have been shock heated by supersonic inflation of the NML. In our view, the most viable scenario for the origin of the X-ray knots is that they are the result of cold gas shock heated by a direct interaction with the jet. The most plausible model of the NML is that it is a bubble from a previous nuclear outburst that is being re-energized by the current outburst. The northeast inner lobe and the large-scale jet are lossless channels through which the jet material rapidly travels to the NML in this scenario. We also report the discovery of a large-scale (at least 35 kpc radius) gas halo around Cen A.
Stabilization of Stochastic Continuous-Time Systems under Data-Rate Constraints

This paper investigates the stabilization problem for stochastic continuous-time linear systems with unknown precess disturbance, where the sensors and controllers are connected by a noiseless digital communication channel. A dynamic output feedback controller is employed to stabilize the unstable plant in the mean square sense. A sufficient condition for stabilization in the presence of limited data rates is derived. Simulation results show the validity of the proposed control scheme.
Population structure in two sympatric species of the Lake Tanganyika cichlid tribe Eretmodini: evidence for introgression

Patterns of genetic differentiation were analysed and compared in two sympatric species of the endemic Lake Tanganyika cichlid tribe Eretmodini by means of mitochondrial DNA (mtDNA) sequences of the control region and six microsatellite DNA loci. The sample area covers a total of 138 km of mostly uninterrupted rocky shoreline in the Democratic Republic of Congo and includes the entire distribution range of Tanganicodus cf. irsacae that stretches over a distance of 35 km. Both markers detected significant genetic differentiation within and between the two species. T. cf. irsacae contained lower overall genetic variation than Eretmoduscyanostictus, possibly due to its more restricted range of distribution and its smaller effective population sizes. Complete fixation of Tanganicodus mtDNA haplotypes was observed in Eretmodus at two localities, while at two other localities some Tanganicodus individuals possessed Eretmodus mtDNA haplotypes. Taking into account the relatively large average sequence divergence of 6.2% between the two species, as well as the geographical distribution of mtDNA haplotypes in the lake, the observed pattern is more likely to be a consequence of asymmetric introgression than of shared ancestral polymorphism. As there is significant population differentiation between sympatric Tanganicodus and Eretmodus populations, the events of introgressions may have happened after secondary contact, but our data provide no evidence for ongoing gene flow and suggest that both species are reproductively isolated at present time.
Behavioral and Neurochemical Recovery from Partial 6-Hydroxydopamine Lesions of the Substantia Nigra Is Blocked by Daily Treatment with Glutamate Receptor Antagonists MK-801 and CPP

To determine whether glutamate plays a role in the recovery from lesions of the substantia nigra, measures of behavioral functioning and extracellular levels of striatal dopamine (DA) were made after partial unilateral 6-OHDA lesions in adult male rats. In experiments 1 and 2, animals were treated on days 1–8 after lesioning with the noncompetitive NMDA receptor antagonist dizocilpine maleate (MK-801; 0.25 mg/kg, i.p.) or saline, and in experiment 3 with the competitive antagonist 3-[(±)-2-carboxypiperazin-4-yl]-propyl-1-phosphonic acid (CPP; 1.0 mg/kg, i.p.) or saline. In experiment 1, behavior was assessed 3 and 8 d after lesioning before daily drug treatment; on days 9 and 10, basal extracellular DA and metabolites were measured in both striata using microdialysis. In experiments 2 and 3, behavior was assessed on days 3 and 15 and microdialysis on days 16 and 17, 8–9 d post-termination of drug treatments. On day 3, all animals turned ipsilateral to the lesion. On days 8 or 15, saline-treated animals showed no behavioral asymmetries, whereas MK-801- and CPP-treated animals turned ipsilaterally. In antagonist-treated animals, basal levels of extracellular DA were lower on the lesioned side whether measured 9–10 or 16–17 d after lesioning, whereas in saline-treated animals DA levels on the two sides did not differ. These results suggest that glutamate plays a role in the development of compensatory changes in the DA neurons that accompany behavioral recovery from partial lesions of nigrostriatal DA system.
The study of thesis replica detecte methods based on similarity of text

To monitor and constraint the plagiarism phenomenon of dissertation, In this paper, we discuss the method of re-investigation method based on similarity of text, and to study dissertation information, the design and realization of chinese text word segmentation and similarity computing with computer system is put forward which make use of TF-IDF method based on VSM combined with the word segmentation system. Theoretical and experimental results showed that the method is feasible and has good space efficiency.
Identification of a Conserved Linear B-Cell Epitope of Streptococcus dysgalactiae GapC Protein by Screening Phage-Displayed Random Peptide Library

The GapC of Streptococcus dysgalactiae (S. dysgalactiae) is a highly conserved surface protein that can induce protective humoral immune response in animals. However, B-cell epitopes on the S. dysgalactiae GapC have not been well identified. In this study, a monoclonal antibody (mAb5B7) against the GapC1-150 protein was prepared. After passive transfer, mAb5B7 could partially protect mice against S. dysgalactiae infection. Eleven positive phage clones recognized by mAb5B7 were identified by screening phage-displayed random 12-peptide library, most of which matched the consensus motif DTTQGRFD. The motif sequence exactly matches amino acids 48-55 of the S. dysgalactiae GapC protein. In addition, the motif 48DTTQGRFD55 shows high homology among various streptococcus species. Site-directed mutagenic analysis further confirmed that residues D48, T50, Q51, G52 and F54 formed the core motif of 48DTTQGRFD55. This motif was the minimal determinant of the B-cell epitope recognized by the mAb5B7. As expected, epitope-peptide evoked protective immune response against S. dysgalactiae infection in immunized mice. Taken together, this identified conserved B-cell epitope within S. dysgalactiae GapC could provide very valuable insights for vaccine design against S. dysgalactiae infection.
Dual Pathway Activated by tert-Butyl Hydroperoxide in Human Airway Anion Secretion

We analyzed the mechanisms underlying the ion transport induced by tert-butyl hydroperoxide (t-BOOH), a membrane-permeant oxidant that has been widely used as a model of oxidative stress, in human airway epithelial cells (Calu-3). We found that t-BOOH induced a short-circuit current that was composed of two distinct components, a peaked component (PC) and a sustained component (SC). Both components were reduced by the presence of H-89 (N-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline) [10 μM, a protein kinase A (PKA) inhibitor] and clofilium (100 μM, a cAMP-dependent K+ channel inhibitor) but not by charybdotoxin (50 nM, a human intermediate conductance Ca2+-activated K+ channel inhibitor), suggesting that both PC and SC were generated through a common PKA-dependent/Ca2+-independent pathway. Notwithstanding, analyses of the physiological properties revealed that PC and SC were attributable to different pathways. PC, but not SC, was correlated with apical membrane Cl- conductance and was inhibited by the cyclooxygenase (COX)-2 inhibitor NS-398 (N-[2-(cyclohexyloxyl)-4-nitrophenyl]-methane sulfonamide; 10 μM). In contrast, SC, but not PC, was composed of a component sensitive to bumetanide (50 μM), an inhibitor of the basolateral Na+-K+-2Cl- cotransporter (NKCC1), and was abolished by the cytoskeleton dysfunction induced by cytochalasin D (10 μM) and (R)-(+)-trans-N-(4-pyridyl)-4-(1-aminoethyl)-cyclohexane carboxamide (Y-27632; 20 μM). Collectively, t-BOOH induces PKA-related anion secretion through two independent pathways: rapid activation of apical anion efflux through a COX-2-dependent/cytoskeleton-independent pathway and relatively delayed activation of NKCC1 for basolateral anion uptake through a COX-2-independent/cytoskeleton-dependent pathway.
Collaborative Strategic Planning On-line

It is widely agreed that the rate of change in many industries is faster than ever before. Strategic decisions are, in addition to top management plans, made on a day-to-day basis closer to the firms markets. In order for the decisions made by individual employees to be strategically coherent it is necessary that the employees develop a shared understanding of some of the basic assumptions and concepts affecting their business environment. This paper presents a computer-based collaboration tool, which is used in the context of strategic planning to facilitate knowledge sharing, knowledge utilization, and learning.
Development of a bipedal robot that walks like an animation character

Our goal is to bring animation characters to life in the real world. We present a bipedal robot that looks like and walks like an animation character. We start from animation data of a character walking. We develop a bipedal robot which corresponds to lower part of the character following its kinematic structure. The links are 3D printed and the joints are actuated by servo motors. Using trajectory optimization, we generate an open-loop walking trajectory that mimics the character's walking motion by modifying the motion such that the Zero Moment Point stays in the contact convex hull. The walking is tested on the developed hardware system.
Inhibition of nitric oxide synthase induces a selective reduction in tumor blood flow that is reversible with L-arginine.

The effect of i.v. administration of the nitric oxide synthase (NOS) inhibitor N(omega)-nitro-L-arginine (L-NNA) on tumor blood flow compared with normal tissue blood flow was studied in anesthetized BD9 rats bearing subcutaneous P22 carcinosarcomas. Blood flow was measured by the tissue uptake of radiolabeled iodoantipyrine. The reversibility of blood flow changes was tested by subsequent administration of L-arginine, the natural substrate for NOS. The effect of L-NNA was compared to that of the imidazolineoxyl N-oxide C-PTIO, a carboxyl derivative of 2-phenyl-4,4,5,5,-tetramethylimidazoline-1-oxyl-3-oxide and a nitric oxide scavenger. Drug-induced changes in mean arterial blood pressure (MABP) were monitored and used to calculate relative drug-induced changes in tissue vascular resistance. Heart rate was measured from blood pressure traces. L-NNA significantly decreased heart rate and increased MABP in a dose-dependent manner. Significant dose-dependent reductions in blood flow with L-NNA were observed in tumor, skeletal muscle, spleen, and skin overlying the tumor. No significant effect was found for normal skin, brain, heart, kidney, and small intestine. At 1 mg/kg, the effect of L-NNA was selective for the tumor, with a significant decrease in tumor blood flow to 0.45 of the control level and no significant effect in any of the normal tissues. Higher doses did not produce any further reduction in tumor blood flow, presumably due to an increase in tumor perfusion pressure arising from the increase in MABP at these doses. Vascular resistance was increased to some extent in all of the tissues studied but, overall, was greatest in the tumor. At 1 mg/kg, there was a 2-2.5-fold increase in tumor vascular resistance but no significant increase in any of the normal tissues. At the highest dose used (10 mg/kg), the increases in vascular resistance in the skeletal muscle and spleen were equivalent to that in the tumor. Administration of L-arginine 15 min after L-NNA completely reversed the decrease in tumor blood flow observed for 1 mg/kg L-NNA alone. In contrast to the effect of L-NNA, constant i.v. infusion of C-PTIO had no effect on tumor or normal tissue blood flow. These results indicate that nitric oxide is important for maintaining a vasodilatory tone in tumors and that inhibition of NOS may provide a means for enhancing therapeutic regimens that would benefit from a selective reduction in tumor blood flow.
Predicting and Evaluating the Epidemic Trend of Ebola Virus Disease in the 2014-2015 Outbreak and the Effects of Intervention Measures

We constructed dynamic Ebola virus disease (EVD) transmission models to predict epidemic trends and evaluate intervention measure efficacy following the 2014 EVD epidemic in West Africa. We estimated the effective vaccination rate for the population, with basic reproduction number (R0) as the intermediate variable. Periodic EVD fluctuation was analyzed by solving a Jacobian matrix of differential equations based on a SIR (susceptible, infective, and removed) model. A comprehensive compartment model was constructed to fit and predict EVD transmission patterns, and to evaluate the effects of control and prevention measures. Effective EVD vaccination rates were estimated to be 42% (31–50%), 45% (42–48%), and 51% (44–56%) among susceptible individuals in Guinea, Liberia and Sierra Leone, respectively. In the absence of control measures, there would be rapid mortality in these three countries, and an EVD epidemic would be likely recur in 2035, and then again 8~9 years later. Oscillation intervals would shorten and outbreak severity would decrease until the periodicity reached ~5.3 years. Measures that reduced the spread of EVD included: early diagnosis, treatment in isolation, isolating/monitoring close contacts, timely corpse removal, post-recovery condom use, and preventing or quarantining imported cases. EVD may re-emerge within two decades without control and prevention measures. Mass vaccination campaigns and control and prevention measures should be instituted to prevent future EVD epidemics.
Performance evaluation of a DDST based SIMO SC system with PAPR reduction

In this paper we concentrate on the symbol level peak to average power ratio (PAPR) increase caused by a data dependent superimposed pilot sequence. Because we add the pilot sequence on top of the user data symbols, the dynamic range of the transmitted signal may increase significantly. We propose the usage of a simple limiter in the transmitter and a hard symbol estimate based iterative estimator for the receiver. We show by simulations that if we allow a modest increase in the symbol level PAPR, the spectral efficiency of the data dependent superimposed pilot based system is better than the traditional time domain multiplexed pilot based system in a block fading channel.
Daptomycin disrupts membrane potential in growing Staphylococcus aureus

Daptomycin (LY146032) caused a calcium-dependent dissipation of the membrane potential (delta psi) in Staphylococcus aureus without noticeably affecting the chemical gradient (delta pH) across the membrane. The effect of daptomycin on membrane energization may account for many of the inhibitory effects on macromolecular biosyntheses and membrane function reported for this antibiotic. Our evidence indicates that the bactericidal activity of daptomycin is dependent on an available delta psi.
Preventing environmental enteric dysfunction through improved water, sanitation and hygiene: an opportunity for stunting reduction in developing countries

Abstract In 2011, one in every four (26%) children under 5 years of age worldwide was stunted. The realization that most stunting cannot be explained by poor diet or by diarrhoea, nor completely reversed by optimized diet and reduced diarrhoea has led to the hypothesis that a primary underlying cause of stunting is subclinical gut disease. Essentially, ingested microbes set in motion two overlapping and interacting pathways that result in linear growth impairment. Firstly, partial villous atrophy results in a reduced absorptive surface area and loss of digestive enzymes. This in turn results in maldigestion and malabsorption of much needed nutrients. Secondly, microbes and their products make the gut leaky, allowing luminal contents to translocate into systemic circulation. This creates a condition of chronic immune activation, which (i) diverts nutrient resources towards the metabolically expensive business of infection fighting rather than growth; (ii) suppresses the growth hormone‐IGF axis and inhibits bone growth, leading to growth impairment; and (iii) causes further damage to the intestinal mucosa thereby exacerbating the problem. As such, the unhygienic environments in which infants and young children live and grow must contribute to, if not be the overriding cause of, this environmental enteric dysfunction. We suggest that a package of baby‐WASH interventions (sanitation and water improvement, handwashing with soap, ensuring a clean play and infant feeding environment and food hygiene) that interrupt specific pathways through which feco‐oral transmission occurs in the first two years of a child's life may be central to global stunting reduction efforts.