Miracle-dz/UniFAR-FTUs huggingface dataset:
QPalm: A gesture recognition system for remote control with list menu

The coming ubiquity of digital media content is driving the need of a solution for improving the interaction between the people and media. In this work, we proposed a novel interaction technique, QPalm, which allows the user to control the media via a list menu shown on a distant display by drawing circles in the air with one hand. To manipulate a list menu remotely, QPalm includes two basic functions, browse and choosing, realized by recognizing the userpsilas palm performing circular and push motions in the air. The circular motion provides fluidity in scrolling a menu up and down, while push motion is intuitive when the user decided to choose an item during a circular motion. Based on this design, we develop a vision system based on a stereo camera to track the userpsilas palm without interfering by intruders behind or next to the operating user. For more specifically, the contribution of the work includes: (1) an intuitive interaction technique, QPalm, for remote control with list menu, and (2) a palm tracking algorithm to support QPalm based on merely depth and motion information of images for a practical consideration.
Acompanhamento terapêutico: intervenção sobre a depressão e o suicídio

This paper investigates the performance of the therapeutic accompaniment in grave depressive subjects with suicidal risk. Suicidal risk assessment protocols and interventions are discussed within the field of therapeutic accompaniment, aiming the implementation of specific actions in mental health. Our conclusion poses that TA an additional therapeutic means for clinical psychiatry of great usefulness and importance. Further research is needed concerning the efficacy and the network of community psychiatry
Cortical functional connectivity under different auditory attentional efforts

Auditory attentional effort (AAE) could be tuned to different levels in a top-down manner, while its neural correlates are still poorly understood. In this paper, we investigate the cortical connectivity under different levels of AAE. Multichannel EEG signals were recorded from nine subjects (male/female=6=3) in an auditory discrimination task under low or high AAE. Behavioral results showed that subjects paid more attention under high AAE and detected the probe stimuli better than low AAE. Partial directed coherence (PDC) was used to study the cortical functional connectivity within the first 300 ms post-stimulus period which includes the N100 and P200 components in the event-related potential (ERP). Majority of the cortical connections were strengthened with the increase of AAE. The right hemispheric dominance of connectivity in maintaining auditory attention was found under low AAE, which disappeared when the AAE was increased, indicating that the right hemispheric dominance previously reported might be due to a relatively lower AAE. Besides, most cortical connections under high AAE were found to be from the parietal cortex to the prefrontal cortex, which suggested the initiative role of parietal cortex in maintaining a high AAE.
Effect of protein kinase C on endoplasmic reticulum cholesterol.

Plasma membrane cholesterol both regulates and is regulated by effector proteins in the endoplasmic reticulum (ER) through a feedback system that is poorly understood. We now show that ER cholesterol varies over a fivefold range in response to experimental agents that act upon protein kinase C (PKC). Agents that activate Ca(2+)-dependent PKC [phorbol-12-myristate-13-acetate (PMA) and bryostatin 1] increased the level of ER cholesterol; inhibitors such as staurosporine and calphostin C decreased it. Rottlerin, a selective inhibitor of the PKC-delta isoform, also increased ER cholesterol. The esterification of plasma membrane cholesterol was altered by protein kinase C-directed agents in a corresponding fashion. Furthermore, the regulatory effect of plasma membrane cholesterol on the esterification of ER cholesterol was blocked by PKC-directed agents. These findings suggest that multiple protein kinase C isoforms participate in the regulation of ER cholesterol and therefore in cholesterol homeostasis.
Acquisition in interlanguage pragmatics

Acquisition in Interlanguage Pragmatics provides readers with a much-needed insight into the development of pragmatic competence, an area of research long neglected in interlanguage pragmatics. The longitudinal investigation which provides the basic material for this book consists of a corpus of requests, offers and refusals of offers elicited from Irish learners of German over a ten-month study abroad period using production questionnaires and a variety of metapragmatic instruments. The analysis focuses on developments in these learners’ knowledge of discourse structure, pragmatic routines and internal modification. Findings present valuable information pertaining to the process of acquisition of pragmatic competence. They also point to the favourable but imperfect nature of the study abroad context for the development of pragmatic competence. A comprehensive discussion of theoretical and methodological issues, an in-depth analysis and an extensive bibliography make this book of interest to both researchers and students in interlanguage pragmatics, cross-cultural pragmatics, German as a foreign language and study abroad research.
Functional MRI of focal and generalised interictal epileptiform discharges

Localizing the source of epileptic discharges is important in gaining a greater understanding of the disease, classifying epilepsy, and identifying areas suitable for potentially curable surgical resection. Functional imaging measures haemodynamic, metabolic or neurochemical correlates to localise neural activity. Combining EEG with functional MRI (EEG-fMRI) allows the localisation of haemodynamic correlates of neuronal events recorded on surface EEG. The work in this thesis aims to identify the spatial haemodynamic correlates of interictal epileptiform discharges (IED) in patients with epilepsy using EEG-fMRI. Five studies form the main body of this thesis. In the first study, 46 patients with frequent generalised spike wave activity (GSW) were studied with EEG-fMRI on a 1.5 Tesla scanner. The main finding was of a characteristic pattern of fMRI signal decrease in frontal, parietal and posterior cingulate cortex, areas of association cortex, during GSW. In the second study, 4 patients from this first series were re-studied with a 3 Tesla scanner. A high degree of reproducibility was seen in the spatial distribution of fMRI changes. Perfusion MRI with an arterial spin label sequence was used that showed a decrease in blood flow to these areas during GSW. In the third study, a novel method for the analysis of fMRI data in epilepsy, temporal clustering analysis (TCA) was assessed. The technique was confounded by subject motion, and we were unable to reliably detect correlates of IED. The fourth study moves away from correlating visually identified IEDs on the EEG, and correlates power fluctuations in the delta frequency band with simultaneously acquired fMRI. Finally a combination of EEG-fMRI and MR tractography were used to study a patient with temporal lobe epilepsy. The issues surrounding potential use of EEG-fMRI as a clinical tool are discussed.
In vitro resolution of poxvirus replicative intermediates into linear minichromosomes with hairpin termini by a virally induced Holliday junction endonuclease

Available evidence suggests that one or more late viral gene products are involved in processing poxvirus replicative intermediates into mature progeny hairpin-terminated genomes. Cloned versions of the Shope fibroma virus (SFV) replicated telomere in the inverted repeat configuration were used as substrates to assay lysates from poxvirus-infected cells for protein fractions that participate in the resolution of the circular substrate plasmid into a linear minichromosome with viral hairpin termini. An activity in a crude protein fraction obtained from vaccinia virus-infected cells at late times during the replicative cycle was capable of accurately resolving all poxviral inverted repeat replicative intermediates tested. The resolved linear products are identical to the products of in vivo resolution and possessed symmetrical nicks which mapped at the borders of the inverted repeat sequence. Strand-specific nicks were also identified, which mapped within the telomere resolution target sequence known to be required for telomere resolution in vivo. The resolving activity that we have identified is specific to virus-infected cells at late times during replication and cleaves cloned poxviral telomeric substrates in a fashion expected of a classic Holliday junction-resolving enzyme in addition to possessing a telomere resolution target-specific nicking activity. Although a Holliday junction-resolving activity would also be expected to play a role in the recombination induced by poxvirus infection, the appearance of the activity described here only after the commencement of viral late protein synthesis suggests that it functions strictly at late times. Other non-viral Holliday junction analogs can also be cleaved by this extract, suggesting that this component of the resolution activity may also play a role in other viral processes that require cleavage of a branched DNA structure. Thus, we have identified a poxviral activity that may be a part of a protein complex which resolves concatemeric replicative intermediates of viral DNA as well as participate in general recombination late during infection.
Predictive Potential of FDG-PET/CT for Histological Transformation in Patients with Indolent Lymphoma

Backgrounds and Purpose—In indolent non-Hodgkin lymphoma, histological transformation is a dramatic event which reduces the prognosis significantly. SUVmax values from FDG-PET/CT help differentiate between aggressive and indolent lymphomas, and transformed indolent lymphomas also show an increased FDG uptake. Possibly FDG uptake increases early in the clinical course and could predict histological transformation. Our objective was to predict histological transformation in indolent lymphomas from initial staging FDG-PET/CT. Patients and Methods—A retrospective study was performed. Patients with biopsy-proven indolent lymphoma who had had initial staging FDG-PET/CT were included. Qualitative (foci compared with FDG uptake liver) and semiquantitative (SUVmax-value per focus) analyses were performed of all abnormal foci. Patient characteristics and outcome were evaluated. Results—We included 88 patients, 5 of whom developed a histological transformation. Semiquantitative analysis showed a relation between maximum standardized uptake value and histological transformation (odds ratio 1.25, 95% CI 1.024 - 1.513). Qualitative analysis showed a negative predictive relation of FDG uptake less than or equal to liver in the occurrence of histological transformation. Transformation-free survival was 100% over 30 months in those with FDG uptake lower than or equal to liver. More FDG uptake than liver showed transformation-free survival of 88% over 30 months. Conclusion—Qualitative analysis of staging FDG-PET/CT in indolent lymphomas could be useful to rule out transformation in the next 30 months. In our study, semiquantitative analysis was statistically significantly associated with histological transformation and maximum standardized uptake value. However, because of the small number of patients, cautious interpretation of the results is warranted. More studies are needed to investigate the role of staging PET/CT in patient with indolent non-Hodkin lymphoma in the prediction of transformation.
Cell population identification using fluorescence-minus-one controls with a one-class classifying algorithm

MOTIVATION The tried and true approach of flow cytometry data analysis is to manually gate on each biomarker separately, which is feasible for a small number of biomarkers, e.g. less than five. However, this rapidly becomes confusing as the number of biomarker increases. Furthermore, multivariate structure is not taken into account. Recently, automated gating algorithms have been implemented, all of which rely on unsupervised learning methodology. However, all unsupervised learning outputs suffer the same difficulties in validation in the absence of external knowledge, regardless of application domain. RESULTS We present a new semi-automated algorithm for population discovery that is based on comparison to fluorescence-minus-one controls, thus transferring the problem into that of one-class classification, as opposed to being an unsupervised learning problem. The novel one-class classification algorithm is based on common principal components and can accommodate complex mixtures of multivariate densities. Computational time is short, and the simple nature of the calculations means the algorithm can easily be adapted to process large numbers of cells (10(6)). Furthermore, we are able to find rare cell populations as well as populations with low biomarker concentration, both of which are inherently hard to do in an unsupervised learning context without prior knowledge of the samples' composition. AVAILABILITY AND IMPLEMENTATION R scripts are available via https://fccf.mpiib-berlin.mpg. de/daten/drfz/bioinformatics/with{username,password}={bioinformatics,Sar=Gac4}.
Keynote Address Project Management Faults and Verification Reconstructing Fine-grained Versioning Repositories with Process Analysis Preface Keynote Address Keynote Address Empirical Software Engineering and Measurement at Microsoft Project Management Process Fragment Based Process Complexity with W

Software engineering is an data rich activity: changes to source code are recorded in version archives, bugs are reported to issue tracking systems, and communications are archived in e-mails and newsgroups. The Empirical Software Engineering and Measurement (ESM) group at Microsoft Research analyzes such data to better understand various software development issues from an empirical perspective. In this talk, I will highlight our research themes and activities using examples from our research on socio technical congruence, bug reporting and triaging, and data-driven software engineering. I will highlight our unique ability to leverage industrial data and developers and the ability to make near term impact on Microsoft via the results of our studies. The work presented in this talk has been done by Chris Bird, Brendan Murphy, Nachi Nagappan, myself, and many others who have visited our group over the past years.
Clinical and Radiological Findings of Autosomal Dominant Osteopetrosis Type II: A Case Report

Osteopetrosis is a rare inherited genetic disease characterized by sclerosis of the skeleton caused by the absence or malfunction of osteoclasts. Three distinct forms of the disease have been recognized, autosomal dominant osteopetrosis being the most common. Autosomal dominant osteopetrosis exhibits a heterogeneous trait with milder symptoms, often at later childhood or adulthood. The aim of this case report is to present the clinical and radiographic features of a 35-year-old female patient with autosomal dominant osteopetrosis type II who exhibited features of chronic generalised periodontitis, and the radiographs revealed generalised osteosclerosis and hallmark radiographic features of ADO type II, that is, “bone-within-bone appearance” and “Erlenmeyer-flask deformity. ”
Schools as Learning Communities: Unpacking the Concept

Because the term “learning community” has been used with increasing frequency to describe schools, this article synthesizes theoretical and empirical research to describe learning community as a construct. The overall purpose is to describe a viable lens through which schools can be viewed in a meaningful manner. First, a summary of the effective schools’ model is used to explain the evolution of learning communities. The construct is then described in terms of three broad dimensions: cognitive, affective, and ideological. A summary with suggestions for future research is provided.
Comparative biological and biochemical studies in hybrid chicks. 2. Susceptibility to aflatoxin and effects on serum protein constituents.

Synopsis Two strains of hybrid chicks (hybrids A and B) were tested for susceptibility to aflatoxin poisoning by single dose administration and by feeding trials. Hybrid A was found to be much more susceptible to aflatoxin than hybrid B. The effect of aflatoxin poisoning on the serum proteins of day‐old chicks of hybrids A and B and of Rhode Red x Light Sussex chicks was examined in survivors 7 days after administering one LD50 of aflatoxin B1. No consistent alterations in electrophoretic protein patterns or serum glycoprotein contents were observed but in the most susceptible group (hybrid A) there was a 12.5 per cent reduction in total protein content.
The role of activists in access to HIV and tuberculosis treatment and prevention

Purpose of review We describe the role of activism in improving access to quality HIV treatment. Recent findings In many countries, AIDS activists have campaigned for improved access to HIV treatment and prevention interventions. Studying medicine, epidemiology and law, and developing expertise in these fields, has been crucial to the success of these campaigns. Also important has been the building of alliances by activists with clinicians, nurses, scientists, and public health policy experts, persuading them of the importance of these campaigns. This article describes examples of campaigns in several middle and low-income countries, showing how activists, by becoming familiar with HIV science, have helped make antiretrovirals available to millions of people across the world. HIV activists have also been drawn into, and driven, broader struggles for health social justice, such as campaigns for new tuberculosis and hepatitis C. Summary Scientists and activists need to continue to work together to improve access to treatment. But to be effective, a critical mass of activists must develop expertise in HIV science and the law.
Where now for proteinuria testing in chronic kidney disease?: Good evidence can clarify a potentially confusing message.

Although the value of testing for proteinuria may be undisputed and understood by nephrologists and diabetologists, the lack of clarity about the rationale for testing and the optimal way of doing so in primary care has caused confusion for many practitioners.1 Issues such as variation in proteinuria definition, laboratory measurement, and reporting methods, along with conflicting messages about who, how, and when to test, have led to uncertainty and under-testing.1,2 There have been long-standing debates about the use of various dipsticks, the role of proteinuria in urinary tract infection, the use of urinary protein:creatinine ratio (PCR) versus albumin:creatinine ratio (ACR), and the number of tests needed for identification versus quantification of proteinuria. Reporting variations include some laboratories using non-numeric results such as ‘ratio too low to calculate’ making visualisation of results and accurate audit of ACR testing challenging for busy practitioners. Urinary dipsticks have important limitations in terms of their accuracy in detecting and quantifying albuminuria.3 In this context, GPs and other clinicians could be forgiven for being uncertain about the clinical utility of its identification. Chronic kidney disease (CKD) has been included in the Quality and Outcomes Framework (QOF) since 2006–2007, and, from 2009–2010, included a proteinuria indicator (‘The percentage of patients on the CKD register whose notes have a record of a urine albumin:creatinine ratio [or protein:creatinine ratio] test in the preceding 12 months’). Currently, several CKD indicators are in the process of being ‘retired’, including the one relating to proteinuria testing. This increases the potential for uncertainty about the role of proteinuria testing and is likely to lead to a fall in ACR tests in England, particularly in people without diabetes, unless it is seen as valuable in its own right. It may also serve to reinforce the suggestion that labelling people …
From Design for Adaptation to Component-Based Resilient Computing

The evolution of systems during their operational lifetime is becoming ineluctable. Dependable systems, which continuously deliver trustworthy services, must evolve in order to comply with changes having different origins, e.g. new fault tolerance requirements, or changes in available resources. These evolutions must not violate their dependability properties, which leads to the notion of resilient computing. This paper presents a methodology for developing adaptive fault tolerance mechanisms, from the design to the actual runtime reconfiguration, leveraging component-based middleware which enable fine-grained manipulation of software architectures.
Aquaporin-4 Is Downregulated in the Basolateral Membrane of Ileum Epithelial Cells during Enterotoxigenic Escherichia coli-Induced Diarrhea in Mice

Enterotoxigenic Escherichia coli (ETEC) are opportunistic pathogens that colonize the small intestine, produce enterotoxins and induce diarrhea. Some aquaporins (AQPs), such as AQP3 and AQP8, have been reported to participate in diarrhea by decreasing cellular influx in the gastrointestinal (GI) tract. AQP4 is another important water channel in the GI tract, but its role in ETEC-induced diarrhea has not been reported. Here, we demonstrated the potential roles of AQP4 in ETEC-induced diarrhea. Reverse transcription-polymerase chain reaction (RT-PCR) and western blotting showed that AQP4 was expressed in the mouse ileum, but not in the duodenum or jejunum while immunohistochemical staining showed that AQP4 localized to the basolateral membrane of ileum epithelial cells. Using an ETEC-induced mice diarrhea model, we demonstrated that both AQP4 mRNA level and the AQP4 protein level in the ileum decreased gradually over a time course of 7 days. These results suggest that AQP4 plays a role in the pathogenesis of ETEC-induced diarrhea by mediating water transport.
Generative Processes in Music: The Psychology of Performance, Improvisation, and Composition

Eric F. Clarke: Generative principles in music performance Alf Gabrielsson: Timing in music and performance and its relations to music experience Johan Sundberg: Computer synthesis of music performance Rudolf A. Rasch: Timing and synchronization in ensemble performance Linda M. Gruson: Rehearsal skill and musical competence: does practice make perfect? W. Jay Dowling: Tonal structure and children's early learning of music Jeff Pressing: Improvisation: methods and models Maria Sagi & Ivan Vitanyi: Experimental research into musical generative ability Lyle Davidson & Lawrence Scripp: Young children's musical representations: windows on music cognition Fred Lerdahl: Cognitive constraints on compositional systems Lyle Davidson & Patricia Welsh: From collections to structure: the development path of tonal thinking.