Miracle-dz/UniFAR-FTUs huggingface dataset:
“AN OPTIMIZED PARALLEL ALGORITHM FOR LONGEST COMMON SUBSEQUENCE USING OPENMP”

- Finding the Longest Common Subsequence has many applications, such as in the field of bioinformatics and computational genomics. The LCS problem consist of an optimal substructure and overlapping sub problems, problems which have such properties can be solved using dynamic programming problem solving technique. Due to the enormous growth in the database sizes, it becomes difficult to solve problems like LCS in less amount of time using classical sequential algorithms. To overcome this problem parallel algorithms are the best solution. In this paper we have presented an optimized parallel LCS algorithm, using OpenMP, for Multi-Core architectures. We have optimized our parallel algorithm by load balancing among the threads, we have divided the score matrix into three parts; growing region, stable region and shrinking region depending upon the number of subproblems and have schedule the subproblems effectively to processing cores for optimal utilization of multicore technology. We realize the implementations of our optimized parallel LCS algorithm on Intel Dual-Core and Quad-Core processors using OpenMP with different scheduling policies. Our optimized parallel algorithm achieves approximately 2.5 speedup factor over the conventional sequential algorithm approach on Intel Quad-Core.
TRIM59 induces epithelial-to-mesenchymal transition and promotes migration and invasion by PI3K/AKT signaling pathway in medulloblastoma

Medulloblastoma is the most common malignant brain tumor in children. Despite remarkable advances over previous decades, the long-term survival of patients with medulloblastoma remains poor due to the frequent metastatic nature of this malignancy. The aim of the present study was to examine the role of tripartite motif containing 59 (TRIM59) in cell metastasis in medulloblastoma. It was initially demonstrated that TRIM59 expression was significantly increased in clinical medulloblastoma tissues compared with adjacent non-cancerous tissues and differentially expressed in a series of medulloblastoma cell lines. The knockdown of TRIM59 in D283 cells resulted in epithelial-to-mesenchymal transition (EMT), and decreased cell migratory and invasive capacities. By contrast, the overexpression of TRIM59 in Daoy cells was able to inhibit the EMT process and increase migratory and invasive capacities of the cells. Notably, the knockdown of TRIM59 was able to decrease the protein level of matrix metalloproteinase (MMP)-2 without altering the levels of MMP-9, and conversely the overexpression of TRIM59 was able to increase the protein level of MMP-2. Importantly, the downregulation of TRIM59 in D283 cells was able to inhibit the levels of phosphorylated (p)-AKT (Ser473), glycogen synthase kinase 3 β(GSK3β; Ser9) and phosphoinositide 3-kinase (PI3K) p85 (Tyr458) without altering the levels of total protein. The data from the present study suggest that TRIM59 induces epithelial-to-mesenchymal transition and promotes migration and invasion by PI3K/AKT signaling pathway in medulloblastoma. This data may provide novel insight into tumor metastasis and pave the way for the development of therapeutic strategies for the treatment of medulloblastoma in the clinic.
Integrating Acupuncture in an Inpatient Setting

Acupuncture, a licensed health care profession in the United States, is poorly integrated into the American health care system, despite the evidence of its effectiveness. The purpose of this study was to offer a phenomenological description of the experience of acupuncturists who delivered acupuncture care in a tertiary teaching hospital in New York City. We analyzed data using methodology proposed by Colaizzi and identified four major clusters of themes: (a) acupuncturists’ excitement about practicing in a hospital setting and frustration about organizational obstacles to effective acupuncture integration; (b) pride in being holistic practitioners; (c) attempts to preserve the holism and effectiveness of acupuncture while adjusting to the limitations of an inpatient setting, and (d) acupuncturists’ realization that the medical staff knew very little about acupuncture and “it’s all about trust. ” Practitioners of other healing traditions and therapies might find our study helpful in their own efforts toward similar integration.
High Susceptibility to Hepatocellular Carcinoma Development in LEC Rats with Hereditary Hepatitis

A remarkably high incidence of hepatocellular carcinomas was observed in long‐surviving LEC rats with hereditary hepatitis. Among the 60 LEC rats examined between 12 and 28 months of age from F29, and F30, 55 (92%) developed putative preneoplastic and neoplastic lesions such as hyperplastic foci and nodules, and hepatocellular carcinomas. Of these, hepatocellular carcinomas were observed with a high frequency (46/55; 84%). All rats of advanced age that survived more than 18 months developed hepatocellular carcinomas. These results suggest that the development of liver tumors in LEC rats is an age‐associated phenomenon with serial hepatic alterations after the subsidence of acute hepatitis. The long‐surviving rats had no normal tissue and showed chronic hepatitis in nontumorous tissues of the liver. Cholangiofibrosis was also found in most rats with hepatic lesions. Metastasis of hepatocellular carcinomas was found in four rats. Histologically, the hepatocellular carcinomas were of a well‐differentiated type with a typical trabecular structure. Thus, LEC rats seem to be a promising animal model for studying the pathogenesis of hepatitis and hepatocellular carcinoma.
Evaluation of local toxicity after repeated intranasal vaccination 0 of guinea-pigs f E

In intranasal vaccination it is important that the adjuvant does not have any toxic effect on the sensitive nasal mucosa. In this study a histological and clinical evaluation of the effects of two different adjuvants in a vaccine containing detoxified diphtheria (DT) and tetanus toxoid (TT) in guinea pigs was done. The guinea pigs were divided in four groups and treated daily for 14 days with different formulations. Group 1 with saline, Groups 2 and 3 with the vaccines in a non-ionic surfactant formulation containing glycerides and Group 4 with tetraethyleneglycol formulation containing glycofurol. The guinea pigs in Groups 1, 2 and 4 were sacrificed on day 15 and Group 3, 1 week later and the tissues processed for histological examination. The animals remained healthy during the treatment and minor clinical signs, such as nose-blowing, decreased with time. The histological appearance, including the development of lymphoid tissue, was comparable in all groups. A specific toxic effect on the nasal mucosa by the different vaccine and adjuvant formulations was not observed.
REVIEW OF THE GREYWATER AND PROPOSED GREYWATER RECYCLING SCHEME FOR AGRICULTURAL IRRIGATION REUSES

In this study, we reviewed greywater characteristics and various treatment technologies with the aim of coming up with the schematic of greywater recycling system designed specifically for restricted agricultural irrigation reuse. Characteristics of greywater are highly variable; greywater amount varies from 50% to 80% of the wastewater volume produced by households. All types of greywater show good biodegradability in terms of COD: BOD5 ratios. The ratio of BOD5/COD in greywater ranged from 0.31 to 0.71. Most countries apply the same standards to reclaimed municipal wastewater as they do to greywater. However, some countries have established specialized standards for greywater reuse. Technologies used for greywater treatment are classified into physical, chemical, biological, and natural systems, or a combination of these. Using physical greywater treatment processes solely as the main treatment method is insufficient for greywater treatment, chemical greywater treatment processes are attractive for single household low-strength greywater treatment systems, as the variability in the strength and flow of the greywater did not affect their treatment performance. Constructed wetland can be regarded as the most environmentally friendly and cost-effective technology for greywater treatment and reuses. Finally, the study suggests the possible greywater recycling scheme for agricultural irrigation reuse purposes.
Impact of smoking on stroke outcome after endovascular treatment

Background Recent studies suggest a paradoxical association between smoking status and clinical outcome after intravenous thrombolysis (IVT). Little is known about relationship between smoking and stroke outcome after endovascular treatment (EVT). Methods We analyzed data of all stroke patients treated with EVT at the tertiary stroke centre of Berne between January 2005 and December 2015. Using uni- and multivariate modeling, we assessed whether smoking was independently associated with excellent clinical outcome (modified Rankin Scale (mRS) 0–1) and mortality at 3 months. In addition, we also measured the occurrence of symptomatic intracranial hemorrhage (sICH) and recanalization. Results Of 935 patients, 204 (21.8%) were smokers. They were younger (60.5 vs. 70.1 years of age, p<0.001), more often male (60.8% vs. 52.5%, p = 0.036), had less often from hypertension (56.4% vs. 69.6%, p<0.001) and were less often treated with antithrombotics (35.3% vs. 47.7%, p = 0.004) as compared to nonsmokers. In univariate analyses, smokers had higher rates of excellent clinical outcome (39.1% vs. 23.1%, p<0.001) and arterial recanalization (85.6% vs. 79.4%, p = 0.048), whereas mortality was lower (15.6% vs. 25%, p = 0.006) and frequency of sICH similar (4.4% vs. 4.1%, p = 0.86). After correcting for confounders, smoking still independently predicted excellent clinical outcome (OR 1.758, 95% CI 1.206–2.562; p<0.001). Conclusion Smoking in stroke patients may be a predictor of excellent clinical outcome after EVT. However, these data must not be misinterpreted as beneficial effect of smoking due to the observational study design. In view of deleterious effects of cigarette smoking on cardiovascular health, cessation of smoking should still be strongly recommended for stroke prevention.
A 14 nA quiescent current inductorless dual-input-triple-output thermoelectric energy harvesting system based on a reconfigurable TEG array

A dual-input-triple-output (DITO) thermoelectric energy harvesting system based on a reconfigurable thermoelectric generator (TEG) array is presented. Higher than 85% efficiency can be achieved over an input voltage range of 0.15V-to-10.8V and an output power range of 38μW-to-200mW with 99% peak efficiency. With adaptive frequency control, the tradeoff between the control overhead and the speed of the control loop is solved and 14 nA quiescent current is achieved. The proposed system provides two regulated output voltages, an energy recycling mechanism and a fast wakeup response, making it particularly suitable for wearable healthcare applications.
Franchisee net income: a signal to choose a franchise in a period of crisis

This paper adopts the perspective of Theory of Signals to discuss how someone starting a business as a franchisee for the first time can choose a suitable franchise brand. The aim was to analyze the relationship between certain signals sent by the franchisor and the choice of a franchise brand by the prospective franchisee. Using panel data, we found that the effects of macroeconomic variables in Spain for the 2006-2013 crisis period influenced franchisees’ net income, which thus became a relevant signal in their process of choosing a franchise brand to start a business.
Similar Increases in Strength After Short-Term Resistance Training Due to Different Neuromuscular Adaptations in Young and Older Men

Abstract Walker, S and Häkkinen, K. Similar increases in strength after short-term resistance training due to different neuromuscular adaptations in young and older men. J Strength Cond Res 28(11): 3041–3048, 2014—This study investigated whether differences in neuromuscular performance and muscle hypertrophy occur between young and older men. Twenty-three young (29 ± 9 years) and 26 older men (64 ± 8 years) completed 10 weeks of high-volume, medium load “hypertrophic” resistance training with low frequency (twice per week) with 10 young (34 ± 11 years) and 11 older men (65 ± 3 years) acting as nontraining control subjects. Training consisted of 2–5 sets of 8–14 repetitions (1- to 2-minute rest). Lower-limb dynamic (leg press) and isometric maximum leg extension force, as well as lower-limb lean mass and vastus lateralis cross-sectional area were assessed before and after the training period. Training led to significant increases in 1 repetition maximum (1RM) leg press performance in both training groups (young: 13 ± 7%, p < 0.001; older: 14 ± 9%, p < 0.001). Performance improvements were accompanied by increased muscle activation, assessed by voluntary activation level (29 ± 51%, p ⩽ 0.05) and electromyography amplitude (35 ± 51%, p < 0.01) in older men only. Conversely, only young men showed significantly increased lower-limb lean mass (2.4 ± 2.5%, p < 0.01). Furthermore, increases in 1RM performance and lower-limb lean mass were significantly related in young men only (r = 0.524, p = 0.01, n = 23). In conclusion, although high-volume, medium load “hypertrophic” resistance training may induce similar improvements in strength between young and older men, it appears that different mechanisms underpin these improvements.
Population prevalence and distribution of ankle pain and symptomatic radiographic ankle osteoarthritis in community dwelling older adults: A systematic review and cross-sectional study

Objectives To identify by systematic review published prevalence estimates of radiographic ankle osteoarthritis (OA) and to subsequently estimate the prevalence of ankle pain and symptomatic, radiographic ankle OA within community-dwelling older adults from North Staffordshire, UK. Methods Electronic databases were searched using terms for ankle, osteoarthritis and radiography. Data regarding population, radiographic methods, definitions and prevalence estimates of ankle OA were extracted from papers meeting predetermined selection criteria. Adults aged ≥50 years and registered with four general practices in North Staffordshire were mailed a health questionnaire. Ankle pain in the previous month was determined using a foot and ankle pain manikin. Respondents reporting pain in or around the foot in the last 12 months were invited to attend a research clinic where weight-bearing, antero-posterior and lateral ankle radiographs were obtained and scored for OA using a standardised atlas. Prevalence estimates for ankle pain and symptomatic, radiographic ankle OA were calculated using multiple imputation and weighted logistic regression, and stratified by age, gender and socioeconomic status. Results Eighteen studies were included in the systematic review. The methods of radiographic classification of ankle OA were poorly reported and showed heterogeneity. No true general population prevalence estimates of radiographic ankle OA were found, estimates in select sporting and medical community-dwelling populations ranged from 0.0–97.1%. 5109 participants responded to the health survey questionnaire (adjusted response 56%). Radiographs were obtained in 557 participants. The prevalence of ankle pain was 11.7% (10.8,12.6) and symptomatic, radiographic ankle OA grade≥2 was 3.4% (2.3, 4.5) (grade≥1: 8.8% (7.9,9.8); grade = 3: 1.9% (1.0,2.7). Prevalence was higher in females, younger adults (50–64 years) and those with routine/manual occupations. Conclusion No general population prevalence estimates of radiographic ankle OA were identified in the published literature. Our prevalence study found that ankle pain was common in community-dwelling older adults, whereas moderate to severe symptomatic, radiographic ankle OA occurred less frequently. Further investigations of the prevalence of ankle OA using more sensitive imaging modalities are warranted.
Agile Millimeter Wave Networks with Provable Guarantees

There is much interest in integrating millimeter wave radios (mmWave) into wireless LANs and 5G cellular networks to benefit from their multiple GHz of available spectrum. Yet unlike existing technologies, e.g., WiFi, mmWave radios require highly directional antennas. Since the antennas have pencil-beams, the transmitter and receiver need to align their antenna beams before they can communicate. Existing solutions scan the entire space to find the best alignment. Such a process has been shown to introduce up to seconds of delay, and is unsuitable for wireless networks where an access point has to quickly switch between users and accommodate mobile clients. This paper presents Rapid-Link, a new protocol that can find the best mmWave beam alignment without scanning the space. Given all possible directions for setting the antenna beam, Rapid-Link provably finds the optimal direction in logarithmic number of measurements. Further, Rapid-Link works within the existing 802.11ad standard for mmWave LAN, and can support both clients and access points. We have implemented Rapid-Link in a mmWave radio and evaluated it empirically. Our results show that it reduces beam alignment delay by orders of magnitude. In particular, for highly directional mmWave devices operating under 802.11ad, the delay drops from over a second to 2.5 ms.
Nuclear Accumulation of p53 in Normal Human Fibroblasts Is Induced by Various Cellular Stresses which Evoke the Heat Shock Response, Independently of the Cell Cycle

Nuclear accumulation of p53 is induced by various DNA damaging agents (the p53 response). Induction of nuclear accumulation of p53 after various cellular stresses, mostly other than DNA damage, including heat shock, was examined in normal human fibroblasts by immunostaining and flow cytometry using a mouse anti‐p53 monoclonal antibody. Immunostaining revealed nuclear accumulation of p53 within 6 h after various stresses [heat shock, osmotic shock, heavy metal (Cd), blockers of the cellular respiratory system (NaN3), amino acid analogues (azetidine and canavanine), an inhibitor of protein synthesis (puromycin), and oxygen free radicals (H2O2)]. Heat shock proved to be one of the most effective inducers among these stresses. FACScan analysis revealed that this induction of p53 occurred regardless of the stage in the cell cycle and that accumulation of cells in G2/M occurred. As all of these stresses are known to induce the heat shock response, the mechanism of p53 induction after stresses and that of heat shock response may share, at least partly, some common signaling pathway(s).
An Automatic Document Classifier System Based on Genetic Algorithm and Taxonomy

The use of the Web has increased the creation of digital information in an accelerated way and about multiple subjects. Text classification is widely used to filter emails, classify Web pages, and organize results retrieved by Web browsers. In this paper, we propose to raise the problem of automatic classification of scientific texts as an optimization problem, which will allow obtaining groups from a data set. The use of evolutionary algorithms to solve classification problems has been a recurrent approach. However, there are a few approaches in which classification problems are solved, where the data attributes to be classified are text-type. In this way, it is proposed to use the association for computing machinery taxonomy to obtain the similarity between documents, where each document consists of a set of keywords. According to the results obtained, the algorithm is competitive, which indicates that the proposal of a knowledge-based genetic algorithm is a viable approach to solve the classification problem.
Effect of ATP and regulatory light-chain phosphorylation on the polymerization of mammalian nonmuscle myosin II

Significance Nonmuscle myosin II (NM2) filaments have essential roles in many cellular processes that require the dynamic relocation of filamentous myosin. We find that addition of ATP to polymerized regulatory light chain (RLC)-unphosphorylated NM2s in vitro results in the formation of dimers, tetramers, hexamers, and monomers, which is reversed by phosphorylation of the RLC. Our data suggest that assembly of NM2 filaments proceeds from folded monomers to folded antiparallel dimers, tetramers, and hexamers that unfold and polymerize into antiparallel filaments. This could explain the dynamic relocalization of NM2 filaments in vivo by dephosphorylation of RLC-phosphorylated filaments, disassembly of the dephosphorylated filaments to monomers, dimers, and small oligomers, diffusion of these species, and their reassembly into filaments at the new location following rephosphorylation of the RLC. Addition of 1 mM ATP substantially reduces the light scattering of solutions of polymerized unphosphorylated nonmuscle myosin IIs (NM2s), and this is reversed by phosphorylation of the regulatory light chain (RLC). It has been proposed that these changes result from substantial depolymerization of unphosphorylated NM2 filaments to monomers upon addition of ATP, and filament repolymerization upon RLC-phosphorylation. We now show that the differences in myosin monomer concentration of RLC-unphosphorylated and -phosphorylated recombinant mammalian NM2A, NM2B, and NM2C polymerized in the presence of ATP are much too small to explain their substantial differences in light scattering. Rather, we find that the decrease in light scattering upon addition of ATP to polymerized unphosphorylated NM2s correlates with the formation of dimers, tetramers, and hexamers, in addition to monomers, an increase in length, and decrease in width of the bare zones of RLC-unphosphorylated filaments. Both effects of ATP addition are reversed by phosphorylation of the RLC. Our data also suggest that, contrary to previous models, assembly of RLC-phosphorylated NM2s at physiological ionic strength proceeds from folded monomers to folded antiparallel dimers, tetramers, and hexamers that unfold and polymerize into antiparallel filaments. This model could explain the dynamic relocalization of NM2 filaments in vivo by dephosphorylation of RLC-phosphorylated filaments, disassembly of the dephosphorylated filaments to folded monomers, dimers, and small oligomers, followed by diffusion of these species, and reassembly of filaments at the new location following rephosphorylation of the RLC.
Augmentation of Cancer Chemotherapy by Preinjection of Human Macrophage Colony‐stimulating Factor in L1210 Leukemic Cell‐inoculated Mice

Human macrophage colony‐stimulating factor (hM‐CSF) is a potent stimulator of the effector functions of monocytes/macrophages. We investigated the antitumor effects of this factor in CDF1 male mice inoculated with L1210 cells, a mouse B‐cell leukemia line. Mice preinoculated with various numbers of L1210 cells on day 0 were given intravenous injections of vehicle (human serum albumin; HSA) (100μg/kg/day) or hM‐CSF (20μg/kg/day) for 3 days from day 1. In mice preinoculated with 102 L1210 cells but not with 103 or more L1210 cells, a marked increment in survival rate was observed with hM‐CSF treatment. We next examined the effect of hM‐CSF treatment combined with chemotherapy on the survival of mice that had been preinoculated with 105 L1210 cells. In our system, the administration of 4.9 mg/kg adriamycin (ADM) alone slightly prolonged survival of the tumorbearing mice, but all of the mice died within 20 days. When hM‐CSF was injected for 3 days before this ADM treatment, the invasion and proliferation of tumor cells in the liver and spleen were markedly inhibited and 50% of the mice were still alive at day 50. We detected inhibitory activity toward L1210 growth in serum of mice administered with hM‐CSF, and the degree of the inhibitory activity was correlated with the level of nitrite (NO2) in the serum. When L1210 cells were co‐cultured with peritoneal macrophages from mice intraperitoneally injected with hM‐CSF, the uptake of [3H]thymidine in L1210 cells was inhibited. The inhibition was abolished by the addition of NG‐monomethyI‐L‐arginine, an inhibitor of NO2− synthesis, suggesting that the reactive nitrogen oxide intermediate is involved in hM‐CSF‐induced inhibition of L1210 growth.