Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluating Robustness of Power Systems Based on Their Topological Structure Using Maximum-Flow Algorithm

To characterize the topological structure of a power system, we first define a dual system for the original one to handle the case where a transmission line is inoperative. Then, we introduce four new indices for a transmission line: dual power supply capacity, capacity balance ratio, dual load limit, and dual overload ratio. We use the maximum-flow algorithm of graph theory along with the indices to analyze the robustness of a power system. Unlike existing methods, this one is very simple; and there is no need to calculate the state of the system repetitively. Finally, the validity of the method is demonstrated using a power system with 18 nodes and 20 branches.
Acculturation, Sexual Risk Taking, and HIV Health Promotion among Latinas

Latinas are nearly 3 times more likely to acquire AIDS than other women in the United States. It is critical to understand this vulnerability and to identify predictors of risk. Structural equation models were used to test predictors mediators (including components of the health belief model) and sex-related outcomes and behavior. Interview data were collected from a random cross-sectional community sample of 227 sexually active Latinas (M age = 32 years). Acculturation was associated with higher HIV-related risks within primary relationships. Older Latinas were less likely than younger Latinas to make behavior changes or use barrier methods of contraception to prevent HIV and they had higher rates of unintended pregnancies. Marriage was related to greater relationship risk and less behavior change. Theoretical models must account for ethnicity race and culture to understand better unwanted sexual outcomes for Latinas including HIV risks. Strategies are needed that specifically address these issues in HIV prevention and counseling programs. (authors)
Women's Sexuality after Cancer: A Qualitative Analysis of Sexual Changes and Renegotiation

Changes to sexual wellbeing and intimacy after cancer were examined through interviews with 41 women; 23 women with cancer and 18 partners of a person with cancer. Thematic analysis identified 2 core themes: 1) Changes to sexuality after cancer: loss of sexual desire, sexual pain, concerns about body image, tiredness, and partner erectile dysfunction; Coital failure equals loss of sex and intimacy; and a counter-narrative in which sexuality is the same after cancer, more commonly reported by non-heterosexual women. 2) Renegotiating Sex: resisting the coital imperative and embracing intimacy. Implications of these findings for therapeutic interventions are discussed.
Learning and training: developing the competent learner

The article proposes a means for optimising the effectiveness of training through a framework developed from two complementary areas; learning theory and competence. The central proposal is that in order to maximise benefits from training there is a need to consider individual’s learning ability. However, improving learning ability requires more than simply seeking to develop study skills. Effective learning involves the development of deeper learning abilities such as critical thinking and identifying the links between different bodies of knowledge. There is also an associated need to examine the knowledge individuals already possess prior to embarking on any further training.
Converting enzyme determines plasma clearance of angiotensin-(1-7).

We determined the mechanism accounting for the removal and metabolism of angiotensin-(1-7) [Ang-(1-7)] in 21 anesthetized spontaneously hypertensive (SHR), 18 age-matched normotensive Sprague-Dawley (SD), and 36 mRen-2 transgenic (TG+) rats. Animals of all 3 strains were provided with tap water or tap water containing losartan, lisinopril, or a combination of lisinopril and losartan for 2 weeks. On the day of the experiment, Ang-(1-7) was infused for a period of 15 minutes at a rate of 278 nmol . kg-1 . min-1. After this time, samples of arterial blood were collected rapidly at regular intervals for the assay of plasma Ang-(1-7) levels by radioimmunoassay. Infusion of Ang-(1-7) had a minimal effect on vehicle-treated SD rats but elicited a biphasic pressor/depressor response in vehicle-treated SHR and TG+ rats. In lisinopril-treated rats, Ang-(1-7) infusion increased blood pressure, whereas losartan treatment abolished the pressor component of the response without altering the secondary fall in arterial pressure. Combined treatment with lisinopril and losartan abolished the cardiovascular response to Ang-(1-7) in all 3 strains. In vehicle-treated SD, SHR and TG+ the half-life (t1/2) of Ang-(1-7) averaged 10+/-1, 10+/-1, and 9+/-1 seconds, respectively. Lisinopril alone or in combination with losartan produced a statistically significant rise in the half-life of Ang-(1-7) in all 3 strains of rats. Plasma clearance of Ang-(1-7) was significantly greater in the untreated SD rats compared with either the SHR or TG+ rat. Lisinopril treatment was associated with reduced clearance of Ang-(1-7) in all 3 strains. Concurrent experiments in pulmonary membranes from SD and SHR showed a statistically significant inhibition of 125I-Ang-(1-7) metabolism in the presence of lisinopril. These studies showed for the first time that the very short half-life of Ang-(1-7) in the circulation is primarily accounted for peptide metabolism by ACE. These findings suggest a novel role of ACE in the regulation of the production and metabolism of the two primary active hormones of the renin angiotensin system.
Time Reversal Polarization and a Z 2 Adiabatic Spin Pump

We introduce and analyze a class of one-dimensional insulating Hamiltonians that, when adiabatically varied in an appropriate closed cycle, define a ``${Z}_{2}$ pump. '' For an isolated system, a single closed cycle of the pump changes the expectation value of the spin at each end even when spin-orbit interactions violate the conservation of spin. A second cycle, however, returns the system to its original state. When coupled to leads, we show that the ${Z}_{2}$ pump functions as a spin pump in a sense that we define, and transmits a finite, though nonquantized, spin in each cycle. We show that the ${Z}_{2}$ pump is characterized by a ${Z}_{2}$ topological invariant that is analogous to the Chern invariant that characterizes a topological charge pump. The ${Z}_{2}$ pump is closely related to the quantum spin Hall effect, which is characterized by a related ${Z}_{2}$ invariant. This work presents an alternative formulation that clarifies both the physical and mathematical meaning of that invariant. A crucial role is played by time reversal symmetry, and we introduce the concept of the time reversal polarization, which characterizes time reversal invariant Hamiltonians and signals the presence or absence of Kramers degenerate end states. For noninteracting electrons, we derive a formula for the time reversal polarization that is analogous to Berry's phase formulation of the charge polarization. For interacting electrons, we show that Abelian bosonization provides a simple formulation of the time reversal polarization. We discuss implications for the quantum spin Hall effect, and argue in particular that the ${Z}_{2}$ classification of the quantum spin Hall effect is valid in the presence of electron electron interactions.
Tool Use in Computer-Based Learning Environments: Adopting and Extending the Technology Acceptance Model

This study adopts the Technology Acceptance Model (TAM) and extends it to study the effects of different variables on tool use. The influence of perceptions on tool use was studied in two different conditions: with and without explanation of the tool functionality. As an external variable, self-efficacy was entered in the TAM and the main research question thus focused on the mediating effects of perceptions (perceived tool functionality and perceived tool usability) between self-efficacy on the one hand and quantity and quality of tool use on the other. Positive effects of perceived usability on perceived functionality were hypothesized as well as positive effects of quantity and quality of tool use on performance. Positive effects were expected in the condition with explanation of the tool functionality. Ninety-three university students were provided with concept maps as the learning tools within a hypertext. Using path analysis, we found—similar to the TAM—a significant positive relationship between perceived usability and perceived functionality. Whereas perceived usability had a positive influence on the quantity of tool use, which positively influenced performance, perceived functionality had a negative influence on quantity of tool use. Self-efficacy showed a relationship with perceived usability only with the explained functionality condition.
Body mass index and waist circumference are better predictors of insulin resistance than total body fat percentage in middle-aged and elderly Taiwanese

Abstract The incidence of diabetes mellitus is rising worldwide, and prediabetic screening for insulin resistance (IR) has become ever more essential. This study aimed to investigate whether body mass index (BMI), waist circumference (WC), or body fat percentage (BF%) could be a better predictor of IR in a middle-aged and elderly population. In this cross-sectional, community-based study, 394 individuals (97 with IR and 297 without IR) were enrolled in the analysis. IR was measured by homeostasis model assessment (HOMA-IR), and subjects with HOMA-IR value ≧75th percentile were defined as being IR. Associations between IR and BMI, WC and BF% were evaluated by t test, chi square, Pearson correlation, logistic regression, and receiver operating characteristic (ROC) curves. A total of 394 community-dwelling, middle-aged, and elderly persons were enrolled; 138 (35%) were male, and 256 were female (65%). The mean age was 64.41 ± 8.46 years. A significant association was identified between BMI, WC, BF%, and IR, with Pearson correlation coefficients of 0.437 (P < .001), 0.412 (P < .001), and 0.361 (P < .001), respectively. Multivariate logistic regression revealed BMI (OR = 1.31; 95% CI = 1.20–1.42), WC (OR = 1.13; 95% CI = 1.08–1.17), and BF% (OR = 1.17; 95% CI = 1.11–1.23) to be independent predictors of IR. The area under curves of BMI and WC, 0.749 and 0.745 respectively, are greater than that of BF% 0.687. BMI and WC were more strongly associated with IR than was BF%. Excess body weight and body fat distribution were more important than total body fat in predicting IR.
HapticClench: Investigating Squeeze Sensations using Memory Alloys

Squeezing sensations are one of the most common and intimate forms of human contact. In this paper, we investigate HapticClench, a device that generates squeezing sensations using shape memory alloys. We define squeezing feedback in terms of it perceptual properties and conduct a psychophysical evaluation of HapticClench. HapticClench is capable of generating up to four levels of distinguishable load and works well in distracted scenarios. HapticClench has a high spatial acuity and can generate spatial patterns on the wrist that the user can accurately recognize. We also demonstrate the use of HapticClench for communicating gradual progress of an activity, and for generating squeezing sensations using rings and loose bracelets.
Gender and Bureaucracies —A Critique of Ferguson's ‘The Feminist Case Against Bureaucracy’

Within the area of gender and organization studies there is a tendency to generalize about organizations and how they affect people working in them. In feminist analysis, salient in Kathy Ferguson's ‘The Feminist Case Against Bureaucracy’, there is a tendency to have a one-sided view on bureaucracies and to regard these merely as products of ‘maleness’ and as incompatible with (radical) feminism. On the basis of a case-study of three different bureaucracies, this article questions the assumption of incompatibility and argues for a more nuanced assessment of gender and bureaucracies.
A Learning Scheme for Blackwell ’ s Approachability in MDPs and Stackelberg Stochastic Games

The notion of approachability was introduced by Blackwell ([8]) in the context of vector-valued repeated games. The famous ‘Blackwell’s approachability theorem’ prescribes a strategy for approachability, i.e., for ‘steering’ the average vector-cost of a given player towards a given target set, irrespective of the strategies of the other players. In this paper, motivated from the multi-objective optimization/decision making problems in dynamically changing environments, we address the approachability problem in Markov Decision Processes (MDPs) and Stackelberg stochastic games with vector-valued cost functions. We make two main contributions. Firstly, we give simple and computationally tractable strategy for approachability for MDPs and Stackelberg stochastic games. Secondly, we give reinforcement learning algorithms to learn the approachable strategy when the transition kernel is unknown. We also show that the conditions that we give for approachability are both necessary and sufficient for convex sets and thus a complete characterization. We also give sufficient conditions for non-convex sets.
Draft Genome Sequence of Comamonas sp. Strain E6 (NBRC 107749), a Degrader of Phthalate Isomers through the Protocatechuate 4,5-Cleavage Pathway

ABSTRACT Comamonas sp. strain E6 can degrade o-phthalate, terephthalate, and isophthalate via the protocatechuate 4,5-cleavage pathway. Here, we report the draft genome sequence of E6 in order to provide insights into its mechanisms in o-phthalate catabolism and its potential use for biotechnological applications.
Model linearization and H∞, controller design for a quadrotor unmanned air vehicle: Simulation study

This paper describes the architecture of a quadrotor and its linearized dynamic model. The attitude of the quadrotor in the model state-space variables can be calculated with rotational matrix formed from quaternions instead of finite small angular displacement approximation. Based on H∞ continuous time control method, a state feedback controller is designed to control the translational position and heading of the quadrotor.
Evidence for Nuclear Processing of Plant Micro RNA and Short Interfering RNA Precursors1[w]

The Arabidopsis genome encodes four Dicer-like (DCL) proteins, two of which contain putative nuclear localization signals. This suggests one or more nuclear pathways for processing double-stranded (ds) RNA in plants. To study the subcellular location of processing of nuclear-encoded dsRNA involved in transcriptional silencing, we examined short interfering (si) RNA and micro (mi) RNA accumulation in transgenic Arabidopsis expressing nuclear and cytoplasmic variants of P19, a viral protein that suppresses posttranscriptional gene silencing. P19 binds specifically to DCL-generated 21- to 25-nucleotide (nt) dsRNAs with 2-nt 3′ overhangs and reportedly suppresses the accumulation of all size classes of siRNA. Nuclear P19 resulted in a significant reduction of 21- to 22-nt siRNAs and a 21-nt miRNA, but had a lesser effect on 24-nt siRNAs. Cytoplasmic P19 did not decrease the quantity but resulted in a 2-nt truncation of siRNAs and miRNA. This suggests that the direct products of DCL cleavage of dsRNA precursors of 21- to 22-nt siRNAs and miRNA are present in the nucleus, where their accumulation is partially repressed, and in the cytoplasm, where both normal sized and truncated forms accumulate. DCL1, which contains two putative nuclear localization signals, is required for miRNA production but not siRNA production. DCL1-green fluorescent protein fusion proteins localize to nuclei in transient expression assays, indicating that DCL1 is a nuclear protein. The results are consistent with a model in which dsRNA precursors of miRNAs and at least some 21- to 22-nt siRNAs are processed in the nucleus, the former by nuclear DCL1 and the latter by an unknown nuclear DCL.
Doing what we imagine: Completion rates and frequency attributes of imagined future events one year after prospection

Recent years have seen an explosion of studies examining behavioural and neural aspects of imagining future events. However, little is known about whether imagined future events reflect future happenings. We examined event occurrence 1 year after participants imagined highly probable future events, specific to place and time. Overall, participants did engage in most of their imagined events. Completion rates were similar to naturalistic prospective memory and implementation intention studies examining personal plan completion. Approximately 20% of events were abandoned. We found participants often imagined events that were repeated many times in the course of a year and this impacted the vividness of recollection, sense of personal importance, personal involvement in event fulfilment, and extent of positive emotionality 1 year later. Together, the results provide an important validation for prospection research and highlight novel dimensions in the temporal structure of future-thinking.
Drug-Induced Perturbations of the Bile Acid Pool, Cholestasis, and Hepatotoxicity: Mechanistic Considerations beyond the Direct Inhibition of the Bile Salt Export Pump

The bile salt export pump (BSEP) is located on the canalicular plasma membrane of hepatocytes and plays an important role in the biliary clearance of bile acids (BAs). Therefore, any drug or new chemical entity that inhibits BSEP has the potential to cause cholestasis and possibly liver injury. In reality, however, one must consider the complexity of the BA pool, BA enterohepatic recirculation (EHR), extrahepatic (renal) BA clearance, and the interplay of multiple participant transporters and enzymes (e.g., sulfotransferase 2A1, multidrug resistance–associated protein 2, 3, and 4). Moreover, BAs undergo extensive enzyme-catalyzed amidation and are subjected to metabolism by enterobacteria during EHR. Expression of the various enzymes and transporters described above is governed by nuclear hormone receptors (NHRs) that mount an adaptive response when intracellular levels of BAs are increased. The intracellular trafficking of transporters, and their ability to mediate the vectorial transport of BAs, is governed by specific kinases also. Finally, bile flow, micelle formation, canalicular membrane integrity, and BA clearance can be influenced by the inhibition of multidrug resistant protein 3- or ATPase-aminophospholipid transporter–mediated phospholipid flux. Consequently, when screening compounds in a discovery setting or conducting mechanistic studies to address clinical findings, one has to consider the direct (inhibitory) effect of the parent drug and metabolites on multiple BA transporters, as well as inhibition of BA sulfation and amidation and NHR function. Vectorial BA transport, in addition to BA EHR and homoeostasis, could also be impacted by drug-dependent modulation of kinases and enterobacteria.
Modifications of the Serotonin System by Antidepressant Treatments: Implications for the Therapeutic Response in Major Depression

Results of electrophysiological single-cell recording studies suggest that most, if not all, types of antidepressant treatments increase 5-hydroxytryptamine (5-HT) neurotransmission. Tricyclic antidepressants, electroconvulsive shock treatment, mianserin, adinazolam, and possibly sleep deprivation may exert their therapeutic effect through sensitization of postsynaptic neurons to 5-HT. Serotonin reuptake blockers may relieve depression through an increased efficacy of the presynaptic element resulting from a desensitization of somatodendritic and terminal 5-HT autoreceptors. Similarly, monoamine oxidase inhibitors may act by increasing the efficacy of 5-HT neurons. Intensification of 5-HT function appears to be a common denominator to antidepressant treatments; however, evidence suggests that this modification may only be a link in a chain of events leading to an antidepressant response.
Dynamic appraisals: A paper with promises

The proposed dynamic systems model of emotion generation indeed appears considerably more plausible and descriptively adequate than traditional linear models. It also comes much closer to the complex interactions observed in neurobiological research. The proposals regarding self-organization in emerging appraisal-emotion interactions are thought-provoking and attractive. Yet, at this point they are more in the nature of promises than findings, and are clearly in need of corroborating psychological evidence or demonstrated theoretical desirability.
A Comparison of Phylogenetic Network Methods Using Computer Simulation

Background We present a series of simulation studies that explore the relative performance of several phylogenetic network approaches (statistical parsimony, split decomposition, union of maximum parsimony trees, neighbor-net, simulated history recombination upper bound, median-joining, reduced median joining and minimum spanning network) compared to standard tree approaches, (neighbor-joining and maximum parsimony) in the presence and absence of recombination. Principal Findings In the absence of recombination, all methods recovered the correct topology and branch lengths nearly all of the time when the substitution rate was low, except for minimum spanning networks, which did considerably worse. At a higher substitution rate, maximum parsimony and union of maximum parsimony trees were the most accurate. With recombination, the ability to infer the correct topology was halved for all methods and no method could accurately estimate branch lengths. Conclusions Our results highlight the need for more accurate phylogenetic network methods and the importance of detecting and accounting for recombination in phylogenetic studies. Furthermore, we provide useful information for choosing a network algorithm and a framework in which to evaluate improvements to existing methods and novel algorithms developed in the future.
A Point Mutation in a Plant Calmodulin Is Responsible for Its Inhibition of Nitric-oxide Synthase*

The calcium/calmodulin-dependent activation of nitric-oxide synthase (NOS) and its production of nitric oxide (NO) play a key regulatory role in plant and animal cell function. SCaM-1 is a plant calmodulin (CaM) isoform that is 91% identical to mammalian CaM (wild type CaM (wtCaM)) and a selective competitive antagonist of NOS (Cho, M. J., Vaghy, P. L., Kondo, R., Lee, S. H., Davis, J. P., Rehl, R., Heo, W. D., and Johnson, J. D. (1998) Biochemistry 37, 15593–15597). We have used site-directed mutagenesis to show that a point mutation, involving the substitution of valine for methionine at position 144, is responsible for SCaM-1's inhibition of mammalian NOS. An M144V mutation in wild type CaM produced a mutant (M144V) which exhibited nearly identical inhibition of NOS's NO production and NADPH oxidation, with a similar K i (∼15 nm) as SCaM-1. A V144M back mutation in SCaM-1 significantly restored its ability to activate NOS's catalytic functions. The length of the hydrophobic amino acid side chain at position 144 appears to be critical for NOS activation, since M144L and M144F activated NOS while M144V and M144C did not. Despite their competitive antagonism of NOS, M144V, like SCaM-1, exhibited a similar dose-dependent activation of phosphodiesterase and calcineurin as wtCaM. SCaM-1 and M144V produced greater inhibition of NOS's oxygenase domain function (NO production) than its reductase domain functions (NADPH oxidation and cytochrome c reduction). Thus, CaM's methionine 144 plays a critical role the activation of NOS, presumably by influencing the function of NOS's oxygenase domain.