Miracle-dz/UniFAR-FTUs huggingface dataset:
Formation and Rigidity of First Impressions as a Function of Perceived Associations

The impetus for the study was the familiar experience, upon initial exposure to a person, of feeling that he or she somehow reminds one of someone else. Curiously, although there is a considerable literature on stereotyping of categories or classes of people (e.g., Brigham, 1971; Katz & Braly, 1933; Prothero’& Melikian, 1955), there has been no systematic research into the effects of interpersonal associations with a previously-encountered individual. on evaluative judgments of a very recentlyencountered person. Along these lines, the present study was designed to investigate the effects of such associations on the formation and modi-
Randomized trial of hyperthermia and radiation for superficial tumors.

PURPOSE Randomized clinical trials have demonstrated hyperthermia (HT) enhances radiation response. These trials, however, generally lacked rigorous thermal dose prescription and administration. We report the final results of a prospective randomized trial of superficial tumors (</= 3 cm depth) comparing radiotherapy versus HT combined with radiotherapy, using the parameter describing the number of cumulative equivalent minutes at 43 degrees C exceeded by 90% of monitored points within the tumor (CEM 43 degrees C T(90)) as a measure of thermal dose. METHODS This trial was designed to test whether a thermal dose of more than 10 CEM 43 degrees C T(90) results in improved complete response and duration of local control compared with a thermal dose of </= 1 CEM 43 degrees C T(90). Patients received a test dose of HT </= 1 CEM 43 degrees C T(90) and tumors deemed heatable were randomly assigned to additional HT versus no additional HT. HT was given using microwave spiral strip applicators operating at 433 MHz. RESULTS One hundred twenty-two patients were enrolled; 109 (89%) were deemed heatable and were randomly assigned. The complete response rate was 66.1% in the HT arm and 42.3% in the no-HT arm. The odds ratio for complete response was 2.7 (95% CI, 1.2 to 5.8; P = .02). Previously irradiated patients had the greatest incremental gain in complete response: 23.5% in the no-HT arm versus 68.2% in the HT arm. No overall survival benefit was seen. CONCLUSION Adjuvant hyperthermia with a thermal dose more than 10 CEM 43 degrees C T(90) confers a significant local control benefit in patients with superficial tumors receiving radiation therapy.
Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation

The cellular prion protein (PrPC) comprises a natively unstructured N‐terminal domain, including a metal‐binding octarepeat region (OR) and a linker, followed by a C‐terminal domain that misfolds to form PrPSc in Creutzfeldt‐Jakob disease. PrPC β‐endoproteolysis to the C2 fragment allows PrPSc formation, while α‐endoproteolysis blocks production. To examine the OR, we used structure‐directed design to make novel alleles, ‘S1’ and ‘S3’, locking this region in extended or compact conformations, respectively. S1 and S3 PrP resembled WT PrP in supporting peripheral nerve myelination. Prion‐infected S1 and S3 transgenic mice both accumulated similar low levels of PrPSc and infectious prion particles, but differed in their clinical presentation. Unexpectedly, S3 PrP overproduced C2 fragment in the brain by a mechanism distinct from metal‐catalysed hydrolysis reported previously. OR flexibility is concluded to impact diverse biological endpoints; it is a salient variable in infectious disease paradigms and modulates how the levels of PrPSc and infectivity can either uncouple or engage to drive the onset of clinical disease.
Analysis of 8 sarcomeric candidate genes for feline hypertrophic cardiomyopathy mutations in cats with hypertrophic cardiomyopathy.

BACKGROUND Hypertrophic cardiomyopathy (HCM) is the most common heart disease in cats. Causative mutations have been identified in the Maine Coon (MC) and Ragdoll breed in the cardiac myosin binding protein C gene (MYBPC3). HCM is thought to be inherited in other breeds. HYPOTHESIS That a causative mutation for HCM in the British Shorthair (BSH), Norwegian Forest (NWF), Siberian, Sphynx, or MC cats would be identified in the exonic and splice site regions of 1 of 8 genes associated with human familial HCM. ANIMALS Three affected BSH, NWF, Siberians, Sphynx, 2 MC (without the known MC mutation), and 2 Domestic Shorthair cats (controls) were studied. METHODS Prospective, observational study. Exonic and splice site regions of the genes encoding the proteins cardiac troponin I, troponin T, MYBPC3, cardiac essential myosin light chain, cardiac regulatory myosin light chain, alpha tropomyosin, actin, and beta-myosin heavy chain were sequenced. Sequences were compared for nucleotide changes between affected cats, the published DNA sequences, and control cats. Changes were considered to be causative for HCM if they involved a conserved amino acid and changed the amino acid to a different polarity, acid-base status, or structure. RESULTS A causative mutation for HCM was not identified, although several single nucleotide polymorphisms were detected. CONCLUSIONS AND CLINICAL IMPORTANCE Mutations within these cardiac genes do not appear to be the only cause of HCM in these breeds. Evaluation of additional cardiac genes is warranted to identify additional molecular causes of this feline cardiac disease.
An Active Approach to Collaborative Filtering

Collaborative filtering allows the preferences of multiple users to be pooled in a principled way in order to make recommendations about products, services or information unseen by a specific user. We consider here the problem of online and interactive collaborative filtering: given the current ratings and recommendations associated with a user, what queries (new ratings) would most improve the quality of the recommendations made? This can be cast in a straightforward fashion in terms of expected value of information; but the online computational cost of computing optimal queries is prohibitive. We show how offline precomputation of bounds on value of information, and of prototypes in query space, can be used to dramatically reduce the required online computation. The framework we develop is quite general, but we derive detailed bounds for the multiplecause vector quantization model, and empirically demonstrate the value of our active approach us-
Antioxidant intake, GSTM1 polymorphism and pulmonary function in healthy young adults

Dietary antioxidants may protect lung tissue against reactive oxygen species-induced injury, adverse respiratory effects and reduced pulmonary function. Genetic variability in antioxidant enzymes also determines response to oxidative stress in the lung. The current authors evaluated whether lung function levels are associated with dietary intake of antioxidants and the glutathione S-transferase M1 (GSTM1) polymorphism. The current study cohort consisted of healthy, nonsmoking freshmen students who were lifetime residents in the Los Angeles or the San Francisco Bay areas (CA, USA). Participants completed comprehensive residential history, health history and food frequency questionnaires. Blood for genotyping was collected and forced expiratory volume measurements were obtained. Dietary vitamin C, magnesium and daily fruit servings were associated positively with forced expiratory volume in one second in males and with maximum mid-expiratory flow, forced expiratory flow after 75% of expelled volume, and the ratio of maximum mid-expiratory flow to forced vital capacity in females. In multivariable regression, vitamin C (or fruit for male students) and magnesium showed a consistent, positive association with lung function. Among healthy female adolescents, dietary intake of vitamin C is associated with increased levels of lung function. The current study does not support a role for the glutathione S-transferase M1-null genotype as an independent risk factor for decrements in lung function.
Insertion proQ220::Tn5 alters regulation of proline porter II, a transporter of proline and glycine betaine in Escherichia coli

Mutation pro-220::Tn5, which increases the resistance of Escherichia coli to 3,4-dehydroproline (M. E. Stalmach, S. Grothe, and J. M. Wood, J. Bacteriol. 156:481-486, 1983), is not linked to putP, proP, or proU. It was located at 40.4 min on the E. coli chromosomal linkage map, by conjugational and transductional mapping, and is now denoted proQ220::Tn5. Proline porter II was not detectable when proQ220::Tn5 proP+ bacteria were cultivated under optimal conditions or with nutritional stress (amino acid limitation). Toxic proline analog sensitivity and proline porter II activity were partially restored to proQ220::Tn5 proP+ bacteria, but not to a proQ220::Tn5 proP219 strain, by a hyperosmotic shift and by growth under osmotic stress. Elevated expression of a proP::lacZ gene fusion, for bacteria grown under osmotic stress, was not influenced by the proQ220::Tn5 insertion. We propose that the proQ locus encodes a positive regulatory element which elevates proline porter II activity.
En historik—om formelle tankeforstyrrelser og det skizofrene spektrum

Nielsen, J. (2005). A histories—on formal thought disorder and schizophrenia spectrum disorders. Nordisk Psykologi, 57, 229–249 On the basis of history of science, the aim of this article is to provide a description of the relationship between formal thought disorder and schizophrenia spectrum disorders. The subject is comprehensive, and therefore this work will focus on a few, but central researchers and their theories, which are representative for a large part of the 20th century. This historic review points out some crucial difficulties that disorders in formal thinking in schizophrenic patients have caused both clinically as well as in a research context. The obstacles have particularly proved to be centred around demarcation and taxonomy. The article demonstrates that this conceptual fussiness can be traced back to uncertainty as regards the identification and operationalisation of the phenomenon of formal thought disorder—questions which in the last resort are linked to the validity of the concept—and are still a subject for research.
Human Movement Sciences Symposium on Perception and Action: Epilogue

All of the major themes of ecological psychology—information, affordances, direct perception, coordination dynamics, learning, and action—are represented in the preceding summaries. The summaries thereby provide a good cross section of the issues being addressed by ecological psychologists as we start the millennium. At the same time, however, none of the articles are business as usual; none would have been written 10 years ago. Turvey’s (this issue) remarks might, at first blush, appear familiar insofar as they reiterate the puzzles of how to appropriately characterize space, a topic that J. J. Gibson had already placed on center stage in his 1950 book. Turvey’s contribution is, first, to charge ecological psychologists to unravel and exploit an action-referential conceptualization of space. In putting ecological thinking about space alongside the names of mathematical, philosophical, and scientific greats, Turvey also goes boldly from ecological concerns into the broader intellectual community. Ecological scientists have had to take on many challenging tasks that were not part of the standard training of experimental psychology (e.g., ecological physics), but the advances booked in these new areas are arguably important not only to the study of perceiving and acting but to all those who seek a broad and coherent natural science. The fact that a concept as ancient as that of space is illuminated by ecological science hints at the broad impact ecological science might bring to bear on the rest of science. Elaborating how ecological thinking fits (or fails ECOLOGICAL PSYCHOLOGY, 16(1), 67–71 Copyright © 2004, Lawrence Erlbaum Associates, Inc.
Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors

Abstract Objective: To summarise quantitatively the association between moderate alcohol intake and biological markers of risk of coronary heart disease and to predict how these changes would lower the risk. Design: Meta-analysis of all experimental studies that assessed the effects of moderate alcohol intake on concentrations of high density lipoprotein cholesterol, apolipoprotein A I, fibrinogen, triglycerides, and other biological markers previously found to be associated with risk of coronary heart disease. Participants: Men and women free of previous chronic disease and who were not dependent on alcohol Studies were included in which biomarkers were assessed before and after participants consumed up to 100 g of alcohol a day. Interventions: Alcohol as ethanol, beer, wine, or spirits. Main outcome measures: Changes in concentrations of high density lipoprotein cholesterol, apolipoprotein A I, Lp(a) lipoprotein, triglycerides, tissue type plasminogen activator activity, tissue type plasminogen activator antigen, insulin, and glucose after consuming an experimental dose of alcohol for 1 to 9 weeks; a shorter period was accepted for studies of change in concentrations of fibrinogen, factor VII, von Willebrand factor, tissue type plasminogen activator activity, and tissue type plasminogen activator antigen. Results: 61 data records were abstracted from 42 eligible studies with information on change in biological markers of risk of coronary heart disease. An experimental dose of 30 g of ethanol a day increased concentrations of high density lipoprotein cholesterol by 3.99 mg/dl (95% confidence interval 3.25 to 4.73), apolipoprotein A I by 8.82 mg/dl (7.79 to 9.86), and triglyceride by 5.69 mg/dl (2.49 to 8.89). Several haemostatic factors related to a thrombolytic profile were modestly affected by alcohol On the basis of published associations between these biomarkers and risk of coronary heart disease 30 g of alcohol a day would cause an estimated reduction of 24.7% in risk of coronary heart disease. Conclusions: Alcohol intake is causally related to lower risk of coronary heart disease through changes in lipids and haemostatic factors. Key messages Results from observational studies provide strong evidence that moderate alcohol intake lowers risk of coronary heart disease Short term trials of alcohol intake show significant changes in concentrations of lipids and clotting factors The changes in concentrations of high density lipoprotein cholesterol, fibrinogen, and triglycerides associated with an intake of 30 g of alcohol a day should reduce risk of coronary disease by 24.7% Alcohol intake may be causally related to lower risk of coronary heart disease through changes in lipids and haemostatic factors
Plasticity of immunity in response to eating

ABSTRACT Following a meal, an animal can exhibit dramatic shifts in physiology and morphology, as well as a substantial increase in metabolic rate associated with the energetic costs of processing a meal (i.e. specific dynamic action, SDA). However, little is known about the effects of digestion on another important physiological and energetically costly trait: immune function. Thus, we tested two competing hypotheses. (1) Digesting animals up-regulate their immune systems (putatively in response to the increased microbial exposure associated with ingested food). (2) Digesting animals down-regulate their immune systems (presumably to allocate energy to the breakdown of food). We assayed innate immunity (lytic capacity and agglutination) in cornsnakes (Pantherophis guttatus) during and after meal digestion. Lytic capacity was higher in females, and (in support of our first hypothesis) agglutination was higher during absorption. Given its potential energetic cost, immune up-regulation may contribute to SDA. Summary: Aspects of immunity can increase nearly 50% during digestion of a meal in snakes; thus, immune up-regulation may contribute to the energetic cost of digestion (specific dynamic action, SDA).
The Level Densities of Random Matrix Unitary Ensembles and their Perturbation Invariability

Using operator methods, we generally present the level densities for kinds of random matrix unitary ensembles in weak sense. As a corollary, the limit spectral distributions of random matrices from Gaussian, Laguerre and Jacobi unitary ensembles are recovered. At the same time, we study the perturbation invariability of the level densities of random matrix unitary ensembles. After the weight function associated with the 1-level correlation function is appended a polynomial multiplicative factor, the level density is invariant in the weak sense.
Linking languages through a bilingual read-aloud project

The present study was carried out in French immersion classrooms in an urban Quebec school board that is increasingly characterised by the heterogeneity of its French-dominant, English-dominant, and French/English bilingual student population. The study explored the extent to which a bilingual read-aloud project would (1) raise teachers' awareness of the bilingual resources of their students, (2) encourage students' cross-linguistic collaboration, and (3) promote teachers' cross-curricular and cross-linguistic collaboration. The participants were three English and three French teachers of three classes of six- to eight-year-old children. The French and English teachers of each class read aloud to their students from the same storybooks over four months, alternating the reading of one chapter in the French class and another in the English class. The data consist of (1) video recordings of the read-aloud sessions and discussion about the stories, (2) interviews and stimulated-recall sessions with the teachers, and (3) student focus-group interviews as well as a student questionnaire administered at the end of the project. Results are reported in terms of the enthusiasm of both students and teachers for the project, the opportunities it created for teachers and students to focus on both language and content, and the extent to which teachers collaborated to do so.
The Old Ways are the Best? The Durability and Usefulness of Bureaucracy in Public Sector Management

The paper addresses the paradoxical question of why, given two decades of ideological and structural reforms in the public sector, has bureaucracy survived both as a concept and in practice. The findings of research conducted in the British National Health Service suggest that bureaucracy is both useful and durable because it means that governments can rely upon the obedience of bureaucrats. In turn, it is suggested that this obedience is a function of bureaucratic vocation, the protection of professional reputation and a form of instrumental motivation. In conclusion, there is a theoretical discussion about the relevance of using Labour Process Theory to explain how state workers (bureaucrats) have experienced social and cultural adaptation to public sector reforms.
High throughput 3D super-resolution microscopy reveals Caulobacter crescentus in vivo Z-ring organization

Significance The bacterial cytoskeletal protein FtsZ, which forms a constricting “Z-ring” during cell division, is the major cytoskeletal protein involved in cell division in almost all prokaryotes, and is a key next-generation antibiotic target. However, the small size of the Z-ring, approximately 500 nm in diameter, makes it difficult to observe in vivo. We provide a quantitative nanoscale picture of Z-ring organization in live cells; these results improve our understanding of the structural and force-generating roles of FtsZ in bacterial cell division. To achieve this, we created an automated modality of superresolution fluorescence microscopy, allowing high-throughput live cell microscopy at nanoscale resolution; this technique should be broadly useful in prokaryotic and eukaryotic systems. We created a high-throughput modality of photoactivated localization microscopy (PALM) that enables automated 3D PALM imaging of hundreds of synchronized bacteria during all stages of the cell cycle. We used high-throughput PALM to investigate the nanoscale organization of the bacterial cell division protein FtsZ in live Caulobacter crescentus. We observed that FtsZ predominantly localizes as a patchy midcell band, and only rarely as a continuous ring, supporting a model of “Z-ring” organization whereby FtsZ protofilaments are randomly distributed within the band and interact only weakly. We found evidence for a previously unidentified period of rapid ring contraction in the final stages of the cell cycle. We also found that DNA damage resulted in production of high-density continuous Z-rings, which may obstruct cytokinesis. Our results provide a detailed quantitative picture of in vivo Z-ring organization.
Bilateral adrenal hemorrhage in polycythemia vera

Bilateral adrenal hemorrhage (BAH) is a rare complication typically seen in critically ill patients, which can lead to acute adrenal insufficiency and death unless it is recognized promptly and treated appropriately. We describe the case of a 64-year-old man with polycythemia vera found to be unresponsive with fever, hypotension, tachycardia, and hypoglycemia. Electrocardiogram showed ST-elevation with elevated troponin, hemoglobin, prothrombin time, and partial thromboplastin time. He required aggressive ventilator and vasopressor support. Despite primary coronary intervention, he remained hypotensive. Random cortisol level was low. He received stress dose hydrocortisone with immediate hemodynamic stability. BAH was highly suspected and was confirmed by non-contrast abdominal computed tomography. Prompt recognition and timely initiated treatment remain crucial to impact the mortality associated with acute adrenal insufficiency.
Efficient spatially combined amplifiers for compact Ku-band satellite communication terminals

Spatially combined amplifiers offer advantages in size and efficiency that are unmatched using traditional solid-state combining approaches. We present measured data from a spatially combined Ku-band deck amplifiertrade for use in the 13.75-14.5 GHz satellite uplink band. This amplifier module generates over 45 dBm (31.6 W) of saturated power by spatially combining the outputs of six commercial MMICs with nearly ideal combining efficiency. The power amplifier module occupies less than 12 cubic inches and draws 165 W DC power while delivering 25 W output. We present linearity and spectral regrowth data for this module and demonstrate the flexibility of the deck amplifier architecture with data for a range of module output powers. The high efficiency of these deck amplifier modules enables creation of very compact, lightweight SSPAs and block upconverters capable of being mounted directly on the feed for small aperture satcom applications such as on-the-move and flyaway
Bilingual first-language development: Dominant language takeover, threatened minority language take-up*

This study explores the extent to which bilingual speakers in stable bilingual communities become fully bilingual in their two community languages. Growing evidence shows that in bilingual communities in which one language is very dominant, acquisition of the dominant language may be quite unproblematic across sub-groups, while acquisition of the minority language can be hampered under conditions of reduced input. In Wales, children are exposed to both English and Welsh from an early age, either in the home or at school, or both. The data reported here indicate that regardless of home language background, speakers develop equivalent, mature command of English, but that command of Welsh is directly correlated with the level of input in Welsh in the home and at school. Furthermore, maintenance of Welsh in adulthood may be contingent on continued exposure to the language. The data have implications for theories of bilingual acquisition in stable versus immigrant bilingual communities, for optimal conditions for bringing up bilingual children, and for theories of critical periods of acquisition.