Miracle-dz/UniFAR-FTUs huggingface dataset:
Lesion stability characteristics outperform degree of stenosis in predicting outcomes following stenting for symptomatic intracranial atherosclerosis

Background Intracranial atherosclerotic disease (ICAD) causes substantial morbidity and mortality. Treatment decisions have most commonly been driven by the degree of luminal stenosis. This study compares ICAD lesion stability features with percentage stenosis for associations with adverse outcomes following treatment with stents. Materials and methods Retrospective analysis was performed of prospectively maintained procedure logs. Lesions were classified by symptom type as hypoperfusion, non-hypoperfusion, or indeterminate, and pretreatment asymptomatic intervals were noted. Hypoperfusion lesions and indeterminate or non-hypoperfusion lesions with ≥14 days of asymptomatic interval were classified as stable. Percentage stenosis was calculated and compared against these other symptom features for value in predicting technical complication, ischemic stroke, disability, or death at 90 days and 2 years using univariate and multivariate analysis. Results 130 lesions were treated in 124 patients. The only statistically significant percent stenosis finding was lesions with 60–99% stenosis were less likely to have technical complications. In univariate analysis, stroke at 2 years was less common with hypoperfusion and stable lesions. In multivariate analysis, only hypoperfusion status was associated with lower stroke rates at 2 years. Conclusions Lesion stability features, particularly non-hypoperfusion symptomatology, outperform percentage stenosis in predicting outcomes following treatment of ICAD with stents. Further examination is needed to better classify the natural history of ICAD and more precisely classify lesion stability.
Effect of Environmental Factors and Influence of Rumen and Hindgut Biogeography on Bacterial Communities in Steers

ABSTRACT Feces from cattle production are considered important sources of bacterial contamination of food and the environment. Little is known about the combined effects of arctic temperatures and fodder tannins on rumen and hindgut bacterial populations. Individual rumen liquor and rectal fecal samples from donor steers fed either alfalfa silage or sainfoin (Onobrychis viciifolia Scop.) silage and water ad libitum were collected weekly on the first three sampling days and fortnightly afterwards. The daily ambient temperatures were registered and averaged to weekly mean temperatures. Steers fed sainfoin silage had lower (P < 0.05) concentrations of branched-chain volatile fatty acids (VFA) than those fed alfalfa silage. All VFA concentrations were higher (P < 0.001) in rumen liquor samples than in fecal samples. The interaction of sample type and diet showed a significant effect (P < 0.05) on the proportions of the bacterial community that were from the phyla Proteobacteria and Verrucomicrobia. Ambient temperature had an indirect effect (P < 0.05) on the phylum Firmicutes, as it affected its proportional balance. The bacterial population diversity in samples appeared to decrease concurrently with the ambient temperature. The phylum Firmicutes explained the first principal component at 64.83 and 42.58% of the total variance in rumen liquor and fecal samples, respectively. The sample type had a larger effect on bacterial communities than diet and temperature. Certain bacterial populations seemed to be better adapted than others to environmentally adverse conditions, such as less access time to nutrients due to higher motility and rate of passage of digesta caused by extreme temperatures, or antimicrobials such as tannins, possibly due to an influence of their biogeographical location within the gut.
NEUROPATHIC PAIN SECTION Original Research Articles Substitution of Gabapentin Therapy with Pregabalin Therapy in Neuropathic Pain due to Peripheral Neuropathy

Objective. To determine the utility of substitution of pregabalin (PGB) for gabapentin (GBP) therapy in the relief of neuropathic pain (NeP) in patients with peripheral neuropathy (PN). Design. A cohort study was performed examining PGB substitution in patients who were GBP responders (30% NeP relief on a visual analog scale [VAS]) or GBP nonresponders after prolonged GBP use, with further comparison to patients receiving continuous GBP therapy. Setting. Patients with PN and related NeP requiring GBP therapy were evaluated in a tertiary care neurological clinic at 0, 6, and 12 months. Outcome Measures. Pain severity (Visual Analog Score [VAS]) was the primary outcome measure, while quality of life (European Quality of Life - 5 Domains [EQ-5D] and EQ-5D VAS) and occurrence of adverse events were secondary outcome measures. Results. Both GBP responder and nonresponder groups had additional NeP relief of about 25% following substitution of PGB after 6 and 12 months, while improved EQ-5D VAS was identified in the GBP nonresponder group. There were no serious adverse events for either medication, while GBP nonresponders discontinued PGB in more than 30% of cases due to inefficacy or adverse events. Conclusions. Randomized, controlled, blinded head-to-head studies of GBP and PGB have not been published. The results of this open-label assessment of PGB substitution for GBP suggest that PGB may provide additional pain relief and possible improvement in quality of life above that received by GBP use in patients with NeP due to PN.
Regulation of Food Safety in the EU: Changing Patterns of Multi-Level Governance

After several food scandals in the past decades, regulatory regimes in food safety have been reformed on the level of the European Union and in most EU member states. In most countries, independent agencies have been created and mainly perform tasks in risk assessment. In our contribution, we focus on national institutional choices concerning these agencies in all 27 member states and ask whether or not these choices can be explained by path dependency or rather as a phenomenon of Europeanization at the national level. Based on a survey of all national regimes and the EU level we can observe some trends that require further scholarly studies. The main feature is that there are two dominant agency models in food safety governance: either a separation of risk assessment from risk management or an integrated model. The first one is a new development triggered by soft Europeanization effects, which are due to functional requirements and learning effects. Furthermore, these agencies have a more or less central role within the emerging network between the European Food Safety Authority EFSA and the national competent authorities.
An Analysis of the Effects of Factors of Production on Foreign Trade in Iran

هلاقم نیا رد بیکرت یسررب هب دیلوت لماوع هب ای ربراک ظاحل هیامرس ندوب رب رب ینامز عطقم هس رد ناریا داصتقا فلتخم یاهتیلاعف تادراو و تارداص 1370 ، 1376 و 1382 هداد شور زا هدافتسا اب – هبساحم هدناتس و رب بسح تسا هدش هئارا تباث یاهتمیق . رد هک تسا نیا رضاح هعلاطم یساسا هیضرف لاغتشا ناریا داصتقا فلتخم یاهشخب اهشخب تادراو هب تبسن تارداص ییاز تسا رتلااب یسررب دروم ینامز هرود رد . هتفای یم ناشن هعلاطم نیا یاه دهد هب رظن زا هک اص یارب هیامرس و راک لماع یریگراک ،اهشخب تادراو و تارد دیلوت لماوع یبسن تیزم زا هدافتسا ساسا رب ناریا یداصتقا یاهتیلاعف ماجنا تسا هدش . ار روشک تادراو مهس زا ییلااب دصرد هک یعیانص تادراو هب دوخ هداد صاصتخا ا دن ییایمیش عیانص ریظن ، نیشام تازلف دیلوت و تلاآ هدوب ییاهشخب وزج ،یساسا یامرس هک دنا ه هب تبسن اهنآ تارداص یبسن یرب تسا هدوب رتشیب تادراو . هیامرس تدش دنور نامز لوط رد عیانص نیا یرب تسا هتشاد یلوزن . یرتشیب مهس هک یعیانص رد تارداص یتفنریغ هتشاد دنا ریظن عیانص بوچ لمح ،یزرواشک ،یبوچ تلاوصحم و یجاسن عیانص ،لقنو هتیلاعف هرمز رد یناگرزاب تامدخ و هدوب ییا یاراد هک دنا هب هیامرس تبسن راک یورین نییاپ دوب یرت ه ینعی هدوب ربراک ًاتبسن دنا .
Effects of amphetamine on subcellular distribution of dopamine and DOPAC

Amphetamine effects on distribution of dopamine, 3,4‐dihydroxyphenylacetic acid (DOPAC), and amphetamine in vesicular, cytosolic, and extracellular compartments associated with a striatal varicosity were estimated through use of a computer simulation model. In addition, contribution to overall effects of amphetamine by each of five actions—transport by dopamine transporter (DAT), transport by vesicular monoamine transporter, stimulation of reverse transport, inhibition of monoamine oxidase (MAO), and slowing of dopamine cell firing rate—were evaluated. Amphetamine enters a varicosity almost entirely by DAT and accumulates to very high levels within the varicosity. Both reverse transport by DAT and passive diffusion contribute to continual amphetamine egress across the plasma membrane. Amphetamine enters storage vesicles by both transport and diffusion. The transport portion competes with dopamine storage, resulting in redistribution of approximately half of dopamine from vesicles to cytosol. The high concentration of amphetamine in the cytosol inhibits MAO, protecting cytosolic dopamine. A very small fraction of cytosolic dopamine is moved to extracellular compartment via reverse transport by DAT. The amount of dopamine moved by reverse transport is limited because of competition by very high cytosolic levels of amphetamine. In the presence of amphetamine, rate of dopamine transfer to extracellular compartment is less than control; however, high levels of extracellular dopamine are maintained because amphetamine occupies the DAT, thus limiting dopamine reuptake. Simulation output from a model using exchange‐diffusion mechanism of reverse transport does not match all published data that were simulated, suggesting that inward transport of a substrate is not required to initiate reverse transport. Synapse, 2012. © 2012 Wiley Periodicals, Inc.
A photochemical and theoretical study of the triplet reactivity of furano- and pyrano-1,4-naphthoquionones towards tyrosine and tryptophan derivatives

The photochemical reactivity of the triplet state of pyrano- and furano-1,4-naphthoquinone derivatives (1 and 2) has been examined employing nanosecond laser flash photolysis. The quinone triplets were efficiently quenched by l-tryptophan methyl ester hydrochloride, l-tyrosine methyl ester hydrochloride, N-acetyl-l-tryptophan methyl ester and N-acetyl-l-tyrosine methyl ester, substituted phenols and indole (kq ∼109 L mol−1 s−1). For all these quenchers new transients were formed in the quenching process. These were assigned to the corresponding radical pairs that resulted from a coupled electron/proton transfer from the phenols, indole, amino acids, or their esters, to the excited state of the quinone. The proton coupled electron transfer (PCET) mechanism is supported by experimental rate constants, isotopic effects and theoretical calculations. The calculations revealed differences between the hydrogen abstraction reactions of phenol and indole substrates. For the latter, the calculations indicate that electron transfer and proton transfer occur as discrete steps.
Right running head: COMPARTMENTALIZED HOMING OF HUMAN MUCOSAL B CELLS Section designation: IMMUNOBIOLOGY Regional induction of adhesion molecules and chemokine receptors explains disparate homing of human B cells to systemic and mucosal effector sites: dispersion from tonsils

F. -E.J., E.S. B. , H.S. C. and I.N. F. contributed equally to this study. F. -E.J. was responsible for the PCR analyses; E.S. B. and I.N. F. performed flow-cytometric analyses; H.S. C. and P.B. were responsible for immunohistochemistry; D.S. provided important new reagents; and P.B. designed the study and wrote the manuscript which was reviewed by all the other co-authors and approved for submission after being finalized.
Does think aloud work?: how do we know?

The think aloud method is widely used in usability research to collect user's reports of the experience of interacting with a design so that usability evaluators can find the underlying usability problems. However, concerns remain about the validity and usefulness of think aloud in usability studies. In this panel we will present current studies of the think aloud method, examine and question its usage in the field, discuss the possible pitfalls that may threaten the validity of the method, and provide comments/suggestions on the application of the method. Panel participants will discuss results drawn from both applied research and basic research.We believe that this panel discussion will be useful for HCI designers and usability practitioners in that it will acquaint them with concerns that people have about the think aloud method and provide them with suggestions for improved use of the method. For HCI or usability researchers, this panel discussion will address the importance of formally investigating currently used or newly designed usability methods.
Effects of feeding high-concentrate diets at restricted intakes on digestibility and nitrogen metabolism in growing lambs.

In Trial 1, 12 wether lambs (34.2 +/- .8 kg BW) were used to determine the effects of restricting intake of diets increasing in percentage of concentrate, to achieve isoenergetic intakes, on digestibility and N metabolism. The trial consisted of two 14-d periods, 9 d for adaptation and 5 d for total collection of urine and feces. Treatments were 22, 39, 61, and 92% concentrate diets fed at ad libitum intake and 90, 80, and 70% of ad libitum intake, respectively. Diets were formulated to provide equal daily intakes of ME. Feeding diets increasing in proportion of concentrate at restricted intakes resulted in linear increases (P < .001) in DM, OM, ADF, and NDF digestibilities. Starch digestibility was not affected (P > .10) by intake. Apparent N digestion was improved (P < .001) with restricted feeding of diets containing greater proportions of concentrate. Nitrogen retention was increased (P < .005) for lambs receiving diets containing a greater proportion of concentrate at reduced intakes. In Trial 2, 12 wether lambs (30.6 +/- .6 kg BW) were used to determine the effects of feeding high-concentrate (92%) diets at reduced intakes on digestibility and N metabolism. Diets were fed at ad libitum intake and 90, 80, and 70% of ad libitum intake. The trial consisted of two 14-d periods, similar to Trial 1. Restricting the intake of high-concentrate diets improved (P < .001) digestibility of DM, OM, ADF, starch, and CP. Digestibility of DM, ADF, CP, and starch increased . 142, . 423, . 497, and . 046 percentage units, respectively, for each 1% reduction in DM intake. (ABSTRACT TRUNCATED AT 250 WORDS)
A 3rd Order Time Domain Delta Sigma Modulator with Extended-Phase Detection

This paper presents a novel analogue to digital converter using an oscillator-based loop filter for high-dynamic range bio-sensing applications. This is the first third-order feedforward ΔΣ modulator that strictly uses time domain integration for quantisation noise shaping. Furthermore we propose a new asynchronous extended-phase detection technique that increases the resolution of the 4 bit phase quantiser by another 5 bits to significantly improve both dynamic range and reduce the noise-shaping requirements. Preliminary simulation results show that this type of loop-filter can virtually prevent integrator saturation and achieves a peak 88 dB SNDR for kHz signals. The proposed system has been implemented using a 180 nm CMOS technology occupying 0.102 mm2 and consumes 13.7 μW of power to digitise the 15 kHz signal bandwidth using a 2 MHz sampling clock.
Increased cell proliferation of mouse fibroblast NIH-3T3 in vitro induced by excretory/secretory product(s) from Opisthorchis viverrini

Infection by Opisthorchis viverrini is a strong risk factor for cholangiocarcinoma. However, the mechanism by which the parasite is involved in carcinogenesis is not clear. In addition to the direct damage of the bile duct epithelium via direct contact with O. viverrini, the excretory/secretory (ES) product(s) released from the parasites may play important roles in this process. We therefore investigated the responses of a fibroblast cell line, NIH-3T3, to ES product(s) released from O. viverrini by using a non-contact co-culture technique. In this culture system, the parasites in the upper chamber had no direct contact with the NIH-3T3 cells in the lower chamber of the culture plate. The results indicated a marked increase in NIH-3T3 cell proliferation in the non-contact co-culture condition with either 0% or 10% calf serum in the medium compared with that without parasites. ES product(s) increased cell proliferation by stimulating the expression of phosphorylated retinoblastoma (pRB) and cyclin D1, the key proteins in driving cells through the G1/S transition point of the cell cycle. This led to the induction of cells going into the S-phase of the cell cycle. ES product(s) also changed the morphology of NIH-3T3 cells to a refractive and narrow shape, which allowed the cells to proliferate in the limited culture area. For the first time, we have been able to demonstrate increased cell proliferation induced by the ES product(s) from O. viverrini; this finding may clarify how O. viverrini ES product(s) affect human bile duct epithelium during cholangiocarcinogenesis.
Anthropometric and anaerobic fitness profile of elite and non-elite female soccer players.

AIM The main aim of the current study was to compare the anthropometrical and fitness profile of female soccer players by level and by playing positions. The second purpose was to explore correlations between kicking speed on the one hand and anthropometric features and explosive strength on the other. METHODS Female soccer players (N.=190) were tested divided in two groups: elite group (N.=100) and non-elite group (N.=90). Body mass, height, leg length, body composition, counter movement jump, drop jump and kicking speed with both legs were measured. RESULTS After controlling for experience with multivariate analysis of covariance (MANCOVA), body mass, body fat and muscle mass differed significantly by level. MANCOVA also revealed that all the anthropometrical variables differed by playing position. However, MANCOVA did not show significant differences by level of play, neither for explosive strength nor for kicking speed but revealed significant differences among playing positions. There were significant positive correlations between body mass, height, leg length, muscle mass, counter movement jump height, drop jump height and experience on the one hand and kicking speed with dominant and non-dominant leg on the other for the elite and non-elite players. CONCLUSIONS Elite players differ from their non-elite counterparts in terms of anthropometrical features, while explosive strength and kicking speed are not sensitive enough to distinguish between levels. On the other hand, the findings indicate few positional variations, and only goalkeepers, tend to have a specific anthropometric and fitness profile. Anthropometric variables, explosive strength and experience have an influence on kicking speed.
The effectiveness of a home visit to prevent childhood injury.

OBJECTIVE To examine the effectiveness of a home visit program to improve home safety and decrease the frequency of injury in children. We examined the effects of the program on 1) parental injury awareness and knowledge; 2) the extent that families used home safety measures; 3) the rate of injury; and 4) the cost effectiveness of the intervention. DESIGN A randomized, controlled trial. SETTING A multicenter trial conducted at 5 hospitals in 4 Canadian urban centers. PARTICIPANTS Children <8 years old, initially enrolled in an injury case-control study, were eligible to participate. Intervention. Subsequent to a home inspection conducted to determine baseline hazard rates for both groups, participants in the intervention group received a single home visit that included the provision of an information package, discount coupons, and specific instruction regarding home safety measures. MAIN RESULTS The median age was 2 years, with males comprising ~60% of participants. The experimental groups were comparable at outset in terms of case-control status, age, gender, and socioeconomic status. Parental injury awareness and knowledge was high; 73% correctly identified injury as the leading cause of death in children, and an intervention effect was not demonstrated. The adjusted odds ratios (ORs) for the home inspection items indicated that significant safety modifications only occurred in the number of homes having hot water not exceeding 54 degrees C (OR: 1.31, 95% confidence interval [CI]: 1.14, 1.50) or the presence of a smoke detector (OR: 1.45, 95% CI: 0.94, 2.22). However, the intervention group reported home safety modifications of 62% at 4 months and significantly less injury visits to the doctor compared with the nonintervention group (rate ratio: 0.75; 95% CI: 0.58, 0.96). The total costs of care for injuries were significantly lower in the intervention group compared with the nonintervention group with a cost of $372 per injury prevented. CONCLUSIONS An intervention using a single home visit to improve the extent to which families use safety measures was found to be insufficient to influence the long-term adoption of home safety measures, but was effective to decrease the overall occurrence of injuries. Future programs should target a few, well-focused, evidence-based areas including the evaluation of high-risk groups and the effect of repeated visits on outcome.
The Diverse AAA+ Machines that Repair Inhibited Rubisco Active Sites

Gaseous carbon dioxide enters the biosphere almost exclusively via the active site of the enzyme ribulose 1,5-bisphosphate carboxylase/oxygenase (Rubisco). This highly conserved catalyst has an almost universal propensity to non-productively interact with its substrate ribulose 1,5-bisphosphate, leading to the formation of dead-end inhibited complexes. In diverse autotrophic organisms this tendency has been counteracted by the recruitment of dedicated AAA+ (ATPases associated with various cellular activities) proteins that all use the energy of ATP hydrolysis to remodel inhibited Rubisco active sites leading to release of the inhibitor. Three evolutionarily distinct classes of these Rubisco activases (Rcas) have been discovered so far. Green and red-type Rca are mostly found in photosynthetic eukaryotes of the green and red plastid lineage respectively, whereas CbbQO is associated with chemoautotrophic bacteria. Ongoing mechanistic studies are elucidating how the various motors are utilizing both similar and contrasting strategies to ultimately perform their common function of cracking the inhibited Rubisco active site. The best studied mechanism utilized by red-type Rca appears to involve transient threading of the Rubisco large subunit C-terminal peptide, reminiscent of the action performed by Clp proteases. As well as providing a fascinating example of convergent molecular evolution, Rca proteins can be considered promising crop-improvement targets. Approaches aiming to replace Rubisco in plants with improved enzymes will need to ensure the presence of a compatible Rca protein. The thermolability of the Rca protein found in crop plants provides an opportunity to fortify photosynthesis against high temperature stress. Photosynthesis also appears to be limited by Rca when light conditions are fluctuating. Synthetic biology strategies aiming to enhance the autotrophic CO2 fixation machinery will need to take into consideration the requirement for Rubisco activases as well as their properties.