Miracle-dz/UniFAR-FTUs huggingface dataset:
Deep Sedation for Dental Care Management in Healthy and Special Health Care Needs Children: A Retrospective Study

Background: Very young children, and those with disabilities and extensive oral pathology, who cannot be treated in the dental chair, require deep sedation or general anesthesia for dental treatment. Objective: The aim of this study is to describe and compare the oral health status in healthy and SHCN children and the treatments performed under deep sedation on an outpatient basis with a minimal intervention approach, and their impact on quality of life. Methods: A retrospective study between 2006 and 2018 was made. A total of 230 medical records of healthy and SHCN children were included. The data extracted were age, sex, systemic health status, reason for sedation, oral health status before sedation, treatments administered during sedation, and follow-up. The quality of life after deep sedation of 85 children was studied through parental questionnaires. Descriptive and inferential analyses were made. Results: Of the 230 children, 47.4% were healthy and 52.6% were SHCN. The median age was 7.10 ± 3.40 years (5.04 ± 2.42 in healthy children and 8.95 ± 3.09 in SHCN children). The main reason for sedation was poor handling in the dental chair (99.5%). The most frequent pathologies were caries (90.9%) and pulp pathology (67.8%). Healthy children had more teeth affected by decay and with pulp involvement. Patients aged < 6 years received more pulpectomies and pulpotomies. After treatment, parents stated that children were more rested and less irascible, ate better, increased in weight, and had improved dental aesthetics. Conclusions: Differences in treatments carried out did not depend on the general health status or the failure rate but on age, with more pulp treatments in healthy children who were younger, and more extractions near to the age of physiological turnover in children with SHCN who were older. Intervention under deep sedation with a minimally invasive treatments approach met the expectations of parents and guardians, as it improved the children’s quality of life.
On the general scaling theory for electrospraying

A systematic dimensional rationale is proposed here to analyse the electrohydro-dynamic equations governing liquid electrospraying phenomena in the well-known steady cone-jet mode with no ambient discharges. As a result, a general, unified description of the complete parametrical space for the emitted current and droplet size is given. Four main distinct subspaces, their relevant boundaries and corresponding scaling laws are identified. Laws already proposed fit in their appropriate region, and previously unknown laws are found. A closed solution for the electric current I when inertia and polarization forces dominate is obtained, in agreement with published experimental results.
Planar dynamics of a rigid body system with frictional impacts. II. Qualitative analysis and numerical simulations

The objective of this paper is to implement and test the theory presented in a companion paper for the non-smooth dynamics exhibited in a bouncing dimer. Our approach revolves around the use of rigid body dynamics theory combined with constraint equations from the Coulomb's frictional law and the complementarity condition to identify the contact status of each contacting point. A set of impulsive differential equations based on Darboux–Keller shock dynamics is established that can deal with the complex behaviours involved in multiple collisions, such as the frictional effects, the local dissipation of energy at each contact point, and the dispersion of energy among various contact points. The paper will revisit the experimental phenomena found in Dorbolo et al. (Dorbolo et al. 2005 Phys. Rev. Lett. 95, 044101), and then present a qualitative analysis based on the theory proposed in part I. The value of the static coefficient of friction between the plate and the dimer is successfully estimated, and found to be responsible for the formation of the drift motion of the bouncing dimer. Plenty of numerical simulations are carried out, and precise agreements are obtained by the comparisons with the experimental results.
GRB Prompt X-ray Emission

Abstract I present the observational properties of the prompt emission of supernova associated GRBs (SN-GRBs) focusing on temporal and spectral characteristics. I compare the properties of SN-GRBs with typical long GRBs to see whether there is a distinct difference or not. Furthermore, I present our attempt to search for hard X-ray emission prior to the discovery date from optically identified type Ibc supernovae using Swift BAT survey data.
Exploring the causal effects of the gut microbiome on serum lipid levels: A two-sample Mendelian randomization analysis

Background The gut microbiome was reported to be associated with dyslipidemia in previous observational studies. However, whether the composition of the gut microbiome has a causal effect on serum lipid levels remains unclear. Objective A two-sample Mendelian randomization (MR) analysis was conducted to investigate the potential causal relationships between gut microbial taxa and serum lipid levels, including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and log-transformed triglyceride (TG) levels. Materials and methods Summary statistics of genome-wide association studies (GWASs) for the gut microbiome and four blood lipid traits were obtained from public datasets. Five recognized MR methods were applied to assess the causal estimates, among which, the inverse-variance weighted (IVW) regression was used as the primary MR method. A series of sensitivity analyses were performed to test the robustness of the causal estimates. Results The combined results from the five MR methods and sensitivity analysis showed 59 suggestive causal associations and four significant causal associations. In particular, genus Terrisporobacter was associated with higher LDL-C (PIVW = 3.01 × 10−6) and TC levels (PIVW = 2.11 × 10−4), phylum Actinobacteria was correlated with higher LDL-C level (PIVW = 4.10 × 10−4), and genus Oscillospira was associated with lower TG level (PIVW = 2.19 × 10−6). Conclusion This research may provide novel insights into the causal relationships of the gut microbiome on serum lipid levels and new therapeutic or prevention strategies for dyslipidemia.
Effect of Mucuna pruriens on brain NMDA receptor and tau protein gene expression in cerebral ischemic rats

Present study aimed to assess effect of pre-treatment with Mucuna pruriens seed extract and its bioactive molecule(s) on NMDAR and Tau protein gene expression in cerebral ischemic rodent model. Methanol extract of M. pruriens seeds was characterized by HPLC, and β-sitosterol was isolated by flash chromatography. In vivo studies to observe the effect of pre-treatment (28 days) with methanol extract of M. pruriens seed and β-sitosterol on the unilateral cerebral ischemic rat model. Cerebral ischemia induced by left common carotid artery occlusion (LCCAO) for 75 min (on day 29) followed by reperfusion for 12 h. Rats (n = 48) divided into four groups. GroupI (control,Untreated + LCCAO)-No pre-treatment + cerebral ischemia; GroupII(β-sitosterol + Sham)-pre-treatment with β-sitosterol, 10 mg/kg/day + sham-operated; GroupIII(β-sitosterol + LCCAO)-pre-treatment with β-sitosterol, 10 mg/kg/day + cerebral ischemia; GroupIV(methanol extract + LCCAO)-pre-treatment with methanol extract of M. pruriens seeds, 50 mg/kg/day + cerebral ischemia. Neurological deficit score was assessed just before sacrifice. Experimental animals were sacrificed after 12 h reperfusion. Brain histopathology was performed. Gene expression of NMDAR and Tau protein of left cerebral hemisphere (occluded side) was performed by RT-PCR. Results revealed that the neurological deficit score was lower in groups III and IV compared to group I. NMDAR and tau protein mRNA expression in left cerebral hemisphere were upregulated in Group I, downregulated in groups III and IV. Histopathology of left cerebral hemisphere (occluded side) in Group I showed features of ischemic brain damage. Groups III and IV, left cerebral hemisphere showed less ischemic damage compared GroupI. Right cerebral hemisphere showed no areas of ischemia-induced brain changes. Pre-treatment with β-sitosterol and methanol extract of M. pruriens seeds may reduce ischemic brain injury following unilateral common carotid artery occlusion in rats.
Statistical modelling of voluntary feed intake in individual Atlantic salmon (Salmo salar L.)

Precision feeding aims to provide the correct amount of feed to farmed animals for optimal growth and performance and to avoid feed waste. However, knowledge underlying the meal-to-meal variability in voluntary feed intake of farmed species is still limited. This study examined the relationship between meals, feed deprivation time and the feed (pellets) consumed by Atlantic salmon post smolts. The data was collected from individual fish handfed to satiety without social interaction in three independent short-term (6-12 days) experiments. The fixed variables of our model (feed deprivation time (i.e., time between meals), number of pellets provided, day, previous meal size, and fish growth) explained most of the feed intake (number of pellets ingested) (R2 0.68). Results show that fish ingested more pellets over the course of the trials as they grew, resulting in a positive correlation between feed intake and fish growth (final minus initial fish weight). The time between meals and prior meal size (the number of pellets ingested in the previous meal) significantly affected feed intake in the following meal. Our results suggest that it is possible to optimise meal size by considering the size of the previous meal and the time since it was given.
A Review Study on Analytical Estimation of Optimal Number of Clusters in Wireless Sensor Networks

To improve energy efficiency, total network scalability and data aggregation in Wireless Sensor Networks (WSNs), sensor nodes are often grouped into disjoint and mostly non overlapping subsets called clusters. To provide an energy-efficient system by clustering, there are three main challenges. First is to find the optimum number of nodes in a specific cluster, second is to find the optimum number of clusters in the network and the third is to find the optimum position of Cluster Head (CH) in a specific cluster. Selecting an optimum number of clusters in WSNs provide greater improvement in terms of system scalability, energy efficiency, collision reduction, network lifetime, latency, and efficient routing backbone in the network. Selection of optimal number of clusters in WSNs is affected by level at which WSNs is modeled viz. Radio Energy Model Level, Network Model Level and Clustering Level. The objective of this paper is to present a state-of-the-art survey of distinct analytical methods used to calculate the optimum number of clusters, and its time-line comparative analysis based on network type, mathematical formula for an optimal number of clusters, base station positioning, energy model, strengths, weaknesses and applications of WSNs. We have also discussed the impact of different parameters on selecting the optimal number of clusters in WSNs.
A contribution to error decrease in plane wave scattering problems with triangular patch modeling

The problem of scattering of plane waves by perfectly conducting bodies using triangular patch modeling is considered. Analytical expressions for the vector coefficients of the matrix equation are presented, which should be used instead of the approximated ones, presented in the original formulation. It is seen that it is the variation of the incident wave phase on the triangle surface that contributes to the error. An analysis of the error is also done; it is null when the direction of incidence is normal to the triangle plane, but it can achieve a value of 20% for equilateral triangles when its side is X/4 and the direction of incidence is in its plane.
Operand-Oriented Virtual Memory Support for Near-Memory Processing

Virtual memory support is one of the major challenges of near-memory processing (NMP). Many previous works focused on this issue, but there are practical limitations that conventional CPU hardware or memory allocation schemes should be modified. Another technique uses a specialized page table for NMP to avoid such limitations. However, the previous work proposed NMP-specific page table that has static page table walk latency regardless of data size. This causes unnecessarily long address translation time for relatively small data. In this paper, we propose an operand-oriented technique for virtual memory support. Our scheme does not pre-determine the size of shared space; rather, it allocates shared space depending on the size of operands data for NMP. Then, we significantly reduce page table walk latency by using our flexible page table, which adapts the page table hierarchy to the size of shared spaces. To prove our concept, we implement our scheme in a full-system simulator and an FPGA-based verification platform. We then compared it with CPU's page table and the previous NMP-specific page table. The experimental results show that our technique outperforms page table walk latency by 69.3 percent and 43.8 percent compared to the CPU's page table and the comparison, respectively.
Beclin-1 dependent autophagy improves renal outcomes following Unilateral Ureteral Obstruction (UUO) injury

Background Interstitial Fibrosis and Tubular Atrophy (IFTA) is the most common cause of long-term graft failure following renal transplant. One of the hallmarks of IFTA is the development of interstitial fibrosis and loss of normal renal architecture. In this study, we evaluated the role of autophagy initiation factor Beclin-1 in protecting against post-renal injury fibrosis. Methods Adult male wild type (WT) C57BL/6 mice were subjected to Unilateral Ureteral Obstruction (UUO), and kidney tissue samples were harvested at 72-hour, 1- and 3-week post-injury. The UUO-injured and uninjured kidney samples were examined histologically for fibrosis, autophagy flux, inflammation as well activation of the Integrated Stress Response (ISR). We compared WT mice with mice carrying a forced expression of constitutively active mutant form of Beclin-1, Becn1F121A/F121A . Results In all experiments, UUO injury induces a progressive development of fibrosis and inflammation. These pathological signs were diminished in Becn1F121A/F121A mice. In WT animals, UUO caused a strong blockage of autophagy flux, indicated by continuously increases in LC3II accompanied by an over 3-fold accumulation of p62 1-week post injury. However, increases in LC3II and unaffected p62 level by UUO were observed in Becn1F121A/F121A mice, suggesting an alleviation of disrupted autophagy. Beclin-1 F121A mutation causes a significant decrease in phosphorylation of inflammatory STING signal and limited production of IL6 and IFNγ, but had little effect on TNF-α, in response to UUO. Furthermore, activation of ISR signal cascade was detected in UUO-injured in kidneys, namely the phosphorylation signals of elF2S1 and PERK in addition to the stimulated expression of ISR effector ATF4. However, Becn1F121A/F121A mice did not reveal signs of elF2S1 and PERK activation under the same condition and had a dramatically reduced ATF level at 3-week post injury. Conclusions The results suggest that UUO causes a insufficient, maladaptive renal autophagy, which triggered downstream activation of inflammatory STING pathway, production of cytokines, and pathological activation of ISR, eventually leading to the development of fibrosis. Enhancing autophagy via Beclin-1 improved renal outcomes with diminished fibrosis, via underlying mechanisms of differential regulation of inflammatory mediators and control of maladaptive ISR.
Serum cytokine levels and other associated factors as possible immunotherapeutic targets and prognostic indicators for lung cancer

Lung cancer is one of the most prevalent cancer types and the leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) accounts for 80-85% of all cancer incidences. Lung cancer therapy and prognosis largely depend on the disease’s degree at the diagnosis time. Cytokines are soluble polypeptides that contribute to cell-to-cell communication, acting paracrine or autocrine on neighboring or distant cells. Cytokines are essential for developing neoplastic growth, but they are also known to operate as biological inducers following cancer therapy. Early indications are that inflammatory cytokines such as IL-6 and IL-8 play a predictive role in lung cancer. Nevertheless, the biological significance of cytokine levels in lung cancer has not yet been investigated. This review aimed to assess the existing literature on serum cytokine levels and additional factors as potential immunotherapeutic targets and lung cancer prognostic indicators. Changes in serum cytokine levels have been identified as immunological biomarkers for lung cancer and predict the effectiveness of targeted immunotherapy.
A Reinforcement Learning Handover Parameter Adaptation Method Based on LSTM-Aided Digital Twin for UDN

Adaptation of handover parameters in ultra-dense networks has always been one of the key issues in optimizing network performance. Aiming at the optimization goal of effective handover ratio, this paper proposes a deep Q-learning (DQN) method that dynamically selects handover parameters according to wireless signal fading conditions. This approach seeks good backward compatibility. In order to enhance the efficiency and performance of the DQN method, Long Short Term Memory (LSTM) is used to build a digital twin and assist the DQN algorithm to achieve a more efficient search. Simulation experiments prove that the enhanced method has a faster convergence speed than the ordinary DQN method, and at the same time, achieves an average effective handover ratio increase of 2.7%. Moreover, in different wireless signal fading intervals, the method proposed in this paper has achieved better performance.
Soil‐layer configuration requirement for large‐eddy atmosphere and land surface coupled modeling

To investigate the soil‐layer configuration requirement for numerical studying large‐eddy scale atmosphere and land surface interactions, we conduct two experiments with an atmosphere and land surface coupled large‐eddy model, one with the ‘usual’ soil‐layer configuration and the other with a finer one. It is found that the former configuration prevents the soil to respond to atmospheric large eddies and the soil acts solely as a fixed external condition to the atmospheric turbulence, and is thus inadequate for large‐eddy atmosphere and land surface coupled modeling. It is shown that soil‐layer configuration has a profound impact on the simulated atmospheric boundary layer dynamics. Copyright © 2013 Royal Meteorological Society
The Analysis of Vitamin D Receptor Protein on Salmonella typhi infection in acute recurrent cases in endemic area in Eastern Indonesia

The host susceptibility mechanisms such as Vitamin D Receptor (VDR) is involved in the modulation of macrophage function and may possibly correlate with immunity disease including the severity of typhoid fever symptoms. The study aimed to assess the VDR Protein expression in the serums of recurrent acute typhoid fever (RATF) patients and compares it with typhoid fever (TF) patients, and healthy persons (HP). The study employed 30 RATF patients and 30 TF patients selected from primary health centres and hospitals in Eastern Indonesia as the endemic area. All the samples were obtained from several health centers in South Sulawesi, Southeast Sulawesi, Central Sulawesi, East Kalimantan and Papua and then collected in the sample bank Biology Laboratory of Molecular Immunology, Faculty of Medicine, Hasanuddin University. As a comparison, 30 samples of healthy persons were also selected from the Blood Transfusion Unit in Makassar, South Sulwesi Indonesia. The profile of VDR Protein was analyzed with Enzyme-linked Immunosorbent Assay (ELISA). VDR protein content data on RATF and TF were designed according to completely randomized design T test. Subsequently, it correlated to Pearson correlation to determine the interaction between Widal titre and VDR protein levels. A comparison between Widal titre and VDR Protein level was also made to identify the correlation. It was found that the mean of VDR protein expression of RATF was 13,44 ng/mL, the mean of VDR protein expression of TF was 24,88 ng/mL, and the mean of VDR protein expression of HP was 43,49 ng/mL. The correlation results between RATF-TF Widal titre and VDR protein level indicated a negative correlation with p-value of 0,004. There were significant differences in the VDR expression in the RATF, TF, and HP. RATF VDR expression lower than TF and HP and there was also a correlation between Widal titre with VDR Protein expression.
Upper and lower bounds of stress-strength interference reliability with random strength-degradation

A stress-strength interference reliability model with strength degradation is established under the assumptions: stress and strength are statistically independent; dynamic loading forces follow a Poisson-process and Gaussian distribution; and random strength-degradation is described by distribution parameter regression models. Simple formulas for estimating upper and lower bounds for strength-stress interference reliability are presented. The results can be applied to reliability estimation in wear out, fatigue, crack growth with dynamic loading forces, etc.
Impact evaluation and economic benefit analysis of a domestic violence and abuse UK police intervention

This study evaluated the impact and economic benefit of Cautioning and Relationship Abuse (CARA), an intervention which aims to reduce re-offending of first-time low-level domestic violence and abuse perpetrators. The analysis was based on two samples drawn from separate UK police force areas. CARA’s impact was assessed using a matched sample of similar offenders from a time when CARA was not available. The matching was based on a host of offender and victim characteristics and machine learning methods were employed. The results show that the CARA intervention has a significant impact on the amount of recidivism but no significant reduction in the severity of the crimes. The benefit-cost ratio in both police force areas is greater than one and estimated to be 2.75 and 11.1, respectively, across the two police force areas. Thus, for each pound (£) invested in CARA, there is an economic benefit of 2.75–11.1 pounds, annually.
Disclosing the relationship between public service motivation and job satisfaction in the Chinese public sector: A moderated mediation model

Introduction Despite the relationship between public service motivation and job satisfaction is widely discussed, rare studies explore the theoretical mechanism of this relationship. Methods Through integrating public service motivation, role overload, job satisfaction, and marital status, this study explores psychological mechanisms and boundary conditions of the relationship between public service motivation and job satisfaction. Data was collected from 349 public employees in eastern China. Results Empirical results reveal that public service motivation is positively related to job satisfaction by decreasing role overload. Moreover, marital status moderates the relationship between role overload and job satisfaction, as well as moderates the indirect effect of public service motivation on job satisfaction through role overload. Discussion These findings advance our understanding of the psychological mechanism and conditional effect of PSM in relation to job satisfaction and provide valuable insights into how to improve public employees’ well-being.