Miracle-dz/UniFAR-FTUs huggingface dataset:
Nonlinear System Identification from Small Data Sets

Abstract We propose a novel algorithm for identification of structured nonlinear systems using a compressive sampling approach. Compressive sampling is an approach to reconstruct randomly sampled signals from small data sets. The proposed algorithm provides empirical evidence to suggest that parameters can potentially be estimated from small data sets using compressive sampling. This approach is illustrated through a simulated example.
Virtual Handball Thrower

Virtual reality offers new tools for human motion understanding. Several applications have been widely used in teleoperation, military training, driving and ying simulators, and so forth. We propose to test if virtual reality is a valid training tool for the game of handball. We focused on the duel between a handball goalkeeper and a thrower. To this end, we dened a pilot experiment divided into two steps: an experiment with real subjects and another one with virtual throwers. The throwers’ motions were captured in order to animate their avatar in a reality center. In this paper, we focused on the evaluation of presence when a goalkeeper is confronting these avatars. To this end, we compared the goalkeeper’s gestures in the real and in the virtual experiment to determine if virtual reality engendered the same movements for the same throw. Our results show that gestures did not differ between the real and virtual environment. As a consequence, we can say that the virtual environment offered enough realism to initiate natural gestures. Moreover, as in real games, we observed the goalkeeper’s anticipation to allow us to use virtual reality in future work as a way to understand the goalkeeper and thrower interactions. The main originality of this work was to measure presence in a sporting application with new evaluation methods based on motion capture.
FRET-Assisted Determination of CLN3 Membrane Topology

Juvenile neuronal ceroid lipofuscinosis (JNCL) is caused by mutations in the CLN3 gene, which encodes for a putative lysosomal transmembrane protein with thus far undescribed structure and function. Here we investigate the membrane topology of human CLN3 protein with a combination of advanced molecular cloning, spectroscopy, and in silico computation. Using the transposomics cloning method we first created a library of human CLN3 cDNA clones either with a randomly inserted eGFP, a myc-tag, or both. The functionality of the clones was evaluated by assessing their ability to revert a previously reported lysosomal phenotype in immortalized cerebellar granular cells derived from Cln3 Δex7/8 mice (CbCln3 Δex7/8). The double-tagged clones were expressed in HeLa cells, and FRET was measured between the donor eGFP and an acceptor DyLight547 coupled to a monoclonal α-myc antibody to assess their relative membrane orientation. The data were used together with previously reported experimental data to compile a constrained membrane topology model for hCLN3 using TOPCONS consensus membrane prediction algorithm. Our model with six transmembrane domains and cytosolic N- and C-termini largely agrees with those previously suggested but differs in terms of the transmembrane domain positions as well as in the size of the luminal loops. This finding improves understanding the function of the native hCLN3 protein.
Cytochrome P450 2A6 and other human P450 enzymes in the oxidation of flavone and flavanone

Abstract 1. We previously reported that flavone and flavanone interact spectrally with cytochrome P450 (P450 or CYP) 2A6 and 2A13 and other human P450s and inhibit catalytic activities of these P450 enzymes. In this study, we studied abilities of CYP1A1, 1A2, 1B1, 2A6, 2A13, 2C9 and 3A4 to oxidize flavone and flavanone. 2. Human P450s oxidized flavone to 6- and 5-hydroxylated flavones, seven uncharacterized mono-hydroxylated flavones, and five di-hydroxylated flavones. CYP2A6 was most active in forming 6-hydroxy- and 5-hydroxyflavones and several mono- and di-hydroxylated products. 3. CYP2A6 was also very active in catalyzing flavanone to form 2′- and 6-hydroxyflavanones, the major products, at turnover rates of 4.8 min−1 and 1.3 min−1, respectively. Other flavanone metabolites were 4′-, 3′- and 7-hydroxyflavanone, three uncharacterized mono-hydroxylated flavanones and five mono-hydroxylated flavones, including 6-hydroxyflavone. CYP2A6 catalyzed flavanone to produce flavone at a turnover rate of 0.72 min−1 that was ∼3-fold higher than that catalyzed by CYP2A13 (0.29 min−1). 4. These results indicate that CYP2A6 and other human P450s have important roles in metabolizing flavone and flavanone, two unsubstituted flavonoids, present in dietary foods. Chemical mechanisms of P450-catalyzed desaturation of flavanone to form flavone are discussed.
Serum uric acid and appropriate cutoff value for prediction of metabolic syndrome among Chinese adults

The relation between serum uric acid and metabolic syndrome is observed not only with frank hyperuricemia but also with serum uric acid levels within the normal range. The current “normal” range set for hyperuricemia often fails to identify patients with potential metabolic disorders. We investigate the association between serum uric acid within the normal range and incident metabolic syndrome risk, and further to determine the optimal cut-off value of serum uric acid for the diagnosis or prediction of metabolic syndrome. A total of 7399 Chinese adults (2957 men and 4442 women; ≥20 years) free of metabolic syndrome were followed for 3 years. During the 3-year follow-up, 1190 normouricemic individuals developed metabolic syndrome (16.1%). After adjusting the associated variables, the top quartile of serum uric acid levels was associated with higher metabolic syndrome development compared with the bottom quartile in men (hazard ratio (HR), 1.29; p<0.05) and women (HR, 1.62; p<0.05). ROC curve analysis indicated that the optimal cut-off values for serum uric acid to identify metabolic syndrome were 6.3 mg/dl in men and 4.9 mg/dl in women. Our results suggested that high baseline serum uric acid levels within the normal range predict future development of metabolic syndrome after 3 y of follow-up.
Comparison of BMI and anthropometric measures among South Asian Indians using standard and modified criteria

Abstract Objective To compare the prevalence rates of obesity based on BMI/anthropometric measures, using WHO standard and ethnicity-specific criteria, the National Cholesterol Education Program–Adult Treatment Panel III (NCEP-ATPIII) and the International Diabetes Federation (IDF) definitions, among a migrant South Asian Indian population. Design Cross-sectional study conducted in October 2007. Subjects A total of 213 participants of South Asian descent over the age of 18 years. Measures included a questionnaire with basic demographic information and self-reported histories of diabetes, coronary artery disease and/or hypercholesterolaemia. Height, weight, waist and hip circumference and blood pressure measurements were obtained. Setting Houston and surrounding suburbs. Results WHO-modified (WHO-mod) BMI and IDF waist circumference (WC) criteria independently identified higher numbers of overweight/obese participants; however, when the WHO-mod BMI or IDF WC criteria were applied, nearly 75 % of participants were categorized as overweight/obese – a proven risk factor for the future development of metabolic syndrome. Conclusions Obesity is likely under-diagnosed using the standard WHO and NCEP-ATPIII guidelines. Stressing the use of modified criteria more universally to classify obesity among South Asian Indians may be optimal to identify obesity and help appropriately risk stratify for intervention to prevent chronic diseases.
Deep parsing in Watson

Two deep parsing components, an English Slot Grammar (ESG) parser and a predicate-argument structure (PAS) builder, provide core linguistic analyses of both the questions and the text content used by IBM Watson™ to find and hypothesize answers. Specifically, these components are fundamental in question analysis, candidate generation, and analysis of passage evidence. As part of the Watson project, ESG was enhanced, and its performance on Jeopardy! ™ questions and on established reference data was improved. PAS was built on top of ESG to support higher-level analytics. In this paper, we describe these components and illustrate how they are used in a pattern-based relation extraction component of Watson. We also provide quantitative results of evaluating the component-level performance of ESG parsing.
Opportunistic Relaying for Two-Way Relay Transmission with Asymmetric Traffic Requirements

This paper investigates opportunistic relaying of a half-duplex two-way relay network, where two source users exchange information through a shared amplify-and-forward (AF) relay which is opportunistically selected from a set of candidates. Unlike existing works, in our considered network scenario, the two source users have different target rates. A novel protocol for opportunistic relaying is developed, which adaptively switches between the max-min and the pure-max policies according to the information of system traffic. The performance of the new relaying strategy in terms of the system outage probability is analyzed over Rayleigh fading channels. Simulation results demonstrate that the proposed protocol can implement opportunistic relaying efficiently, and can achieve significant performance gains in terms of the outage probability across all traffics.
Programmed cell death 4 and microRNA 21 inverse expression is maintained in cells and exosomes from ovarian serous carcinoma effusions

Ovarian serous carcinoma (OSC) is a fatal gynecologic malignancy usually presenting with bilateral localization and malignant peritoneal effusion. Programmed cell death 4 (PDCD4) is a tumor suppressor gene whose expression is directly controlled by microRNA‐21 (miR‐21). Exosomes are small cell‐derived vesicles that participate in intercellular communication, delivering their cargo of molecules to specific cells. Exosomes are involved in several physiological and pathological processes including oncogenesis, immunomodulation, angiogenesis, and metastasis. The current study analyzed the expression of PDCD4 and miR‐21 in resected OSC specimens and in cells and exosomes from OSC peritoneal effusions.
Risk of warfarin-associated intracerebral haemorrhage after ischaemic stroke is low and unchanged during the 2000s

Commentary on : Asberg A, Erisksson M, Henriksson KM, et al. Warfarin-associated intracerebral hemorrhage after ischemic stroke. Stroke 2014;45:2118–20. [OpenUrl][1][Abstract/FREE Full Text][2] Since its isolation during the early half of the 20th century from the mouldy hay responsible for ‘sweet clover disease’ in cattle, warfarin has become the most widely used oral anticoagulant.1 Indications include atrial fibrillation (AF), mechanical prosthetic valves and venous thromboembolism treatment.2 Warfarin reduces stroke risk in patients with AF by nearly two-thirds; AF accounts for 20% of ischaemic strokes, which tend to be more severe than those due to other aetiologies. In the late 1990s, reports began to emerge concluding that patients … [1]: {openurl}? query=rft.jtitle%253DStroke%26rft_id%253Dinfo%253Adoi%252F10.1161%252FSTROKEAHA.114. 005729%26rft_id%253Dinfo%253Apmid%252F24876246%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink? linkType=ABST&journalCode=strokeaha&resid=45/7/2118&atom=%2Febmed%2F20%2F1%2F36.atom
Market Power Assessment and Mitigation in Hydrothermal Systems

The objective of this paper is to investigate market power issues in bid-based hydrothermal scheduling. Initially, market power is simulated with a single-stage Nash-Cournot equilibrium model. Market power assessment for multiple stages is then carried through a stochastic dynamic programming scheme. The decision in each stage and state is the equilibrium of a multi-agent game. Thereafter, mitigation measures, specially bilateral contracts, are investigated. Case studies with data taken from the Brazilian system are presented and discussed.
The number of countable models in categories of sheaves

The goal of this paper is to extend Morley’s results in [10] to categories of sheaves. We show that in this context there are four natural notions of “a countable model”. We then show Π3 determinacy implies that for any of these four notions and for any sentence T ∈ Lω1,ω(L) either there is a perfect set of non-isomorphic models of T in our category of sheaves or else there are at most א1 many non-isomorphic models of T in our category of sheaves. We also show that for one of the four notions of countable we can remove the determinacy assumption.
Document restoration and enhancement using optimal iterative and paired morphological filters

Restoration and enhancement of digital documents typically involves use of binary filters. Various methods have been developed to facilitate automatic design of optimal binary filters in the context of morphological image processing. Among these are iterative increasing filters for designing optimal increasing filters in stages, and paired- representation filters, in which a nonincreasing filter is represented as a union of anti-extensive and extensive increasing filters. The present paper applies these filters in three different modalities for digital document enhancement. Iterative design is illustrated in the context of document restoration for dilated, background-noise images; iterative, paired design is illustrate in for restoration of edge-degraded characters; and paired design is used for integer resolution conversion.
Interpretation of Clinical Next-Generation Sequencing Data: A Hurdle to Jump Over

Next-generation sequencing (NGS) has been revolutionary for the clinical diagnostics field. With its high throughput sequencing power and plummeting cost, it has been increasingly used in clinical labs. Instead of testing the candidate genes one at a time by Sanger sequencing, now a lab can test a group of candidate genes at the same time using the NGS method. For example, many clinical labs now offer epilepsy gene panel tests that usually sequence 100-500 genes that are known to be causal or have associations with different kinds of epilepsies. Gene panel tests are also offered for genetic heterogeneous diseases like neurodevelopmental disease, cardiomyopathy, immunodeficiency disease, etc. This approach dramatically increases diagnostic efficiency and helps clinicians to zoom in on the genetic cause for a certain disease in a timely manner. In addition, the NGS technology is also used to diagnose patients who have been through diagnostic odysseys. Exome sequencing is currently used for this purpose in clinical labs. Exome test sequences an exome that contains all the protein coding regions which comprises 1.5% of the genome but contains 80% of recognized disease-causing mutations. Numerous examples illustrated that the exome sequencing method can efficiently identify genetic causes for undiagnosed diseases, which not only helps clinicians to obtain accurate diagnoses but also guides clinicians in the personalized care and treatment of their patients [1,2].
In vitro synthesis and glycosylation of androgen‐dependent secretory proteins of rat dorsal prostate and coagulating gland

The two major androgen‐dependent secretory proteins of rat dorsal prostate and coagulating gland, DP I and DP II, were compared by in vitro translation of total poly(A)RNA and by pulse‐chase techniques by means of [35S]methionine and tissue minces of coagulating gland. DP I is a major in vitro translation product of isolated poly(A)RNA, whereas DP II is undetectable in a mouse embryo fibroblast cell‐free system where glycosylation does not occur. DP I is synthesized within 20 min in minces of coagulating gland incubated in the presence of [35S]methionine and is secreted in 40 min. DP II is detectable in the medium only after 8 hr of labeling. Inhibition of asparagine‐linked protein glycosylation with tunicamycin (10 μg/ml) blocked the synthesis and secretion of DP II with an apparent increase in DP I secretion. Inhibition of DP II synthesis by monensin implicates the Golgi in the processing of DP II oligosaccharides. The data are consistent with the proposal that DP I enters a pathway of rapid secretion that is enhanced by the absence of core glycosylation, whereas DP II follows a slow pathway through the Golgi that involves extensive glycosylation.
The Role of Stimulus Specificity and Attention in the Generalization of Extinction

Exposure therapy for anxiety is effective but fear can still return afterward. This may be because the stimuli that people are exposed to are dissimilar from the stimuli to which fear was originally acquired. After pairing an animal-like image (A) with a shock stimulus (US), a perceptually similar stimulus (B) was presented without the US in extinction. Participants were then shown A (ABA), a second generalization stimulus (ABC) or B (ABB). Groups ABA and ABC evidenced a return of US expectancy relative to participants who were shown B (ABB). Participants in group ABC who self-reported high levels of attentional control evidenced greater return of expectancy relative to participants low in attentional control. Participants with a high level of attentional control also showed steeper extinction gradients. Attentional control may influence perceptions of similarity and the learning that follows. Making note of such differences may be valuable in exposure treatment for anxiety.
Automated real-time correction of exposure times in a multispectral camera using an ambient light sensor

Maintaining appropriate exposure times is challenging in applications that involve continuous capturing and processing of images in an environment of dynamically changing light. This problem is typically solved by post processing the captured images and adapting the exposure time for the next image based on some brightness metric derived from a previous image. However, this results in a delay between the light changing and the exposure time being properly updated, resulting in under- or overexposed images. In this article we propose using a light sensor to actively measure the changing light and use this to calculate the appropriate exposure time prior to images being captured. We show that by using this method we can capture images that are appropriately exposed for maximum contrast even when the ambient light changes dramatically.
Value Assessment of Ecosystem Services in Nature Reserves in Ningxia, China: A Response to Ecological Restoration

Changes in land use can cause significant changes in the ecosystem structure and process variation of ecosystem services. This study presents a detailed spatial, quantitative assessment of the variation in the value of ecosystem services based on land use change in national nature reserves of the Ningxia autonomous region in China. We used areas of land use types calculated from the remote sensing data and the adjusted value coefficients to assess the value of ecosystem services for the years 2000, 2005, and 2010, analyzing the fluctuations in the valuation of ecosystem services in response to land use change. With increases in the areas of forest land and water bodies, the value of ecosystem services increased from 182.3×107 to 223.8×107 US$ during 2000–2010. Grassland and forest land accounted for 90% of this increase. The values of all ecosystem services increased during this period, especially the value of ecosystem services for biodiversity protection and soil formation and protection. Ecological restoration in the reserves had a positive effect on the value of ecosystem services during 2000–2010.
Enhanced utility in preserving privacy for multiple heterogeneous sensitive attributes using correlation and personal sensitivity flags

Preserving privacy is becoming a key apprehension as personal data is publicly available in recent years. Most of the present Privacy Preserving Data Publishing (PPDP) methods could not process multiple, heterogeneous sensitive attributes with different levels of sensitivity requirements. This motivates us to suggest a novel methodology that can handle multiple heterogeneous (both numerical and categorical) sensitive attributes. Unlike the existing methods that applies same amount of privacy for all the data records without considering record owner's concrete needs, our technique considers Personal Sensitivity Rating Flags (PSRF) from record owners and apply privacy preserving techniques on those records that actually needs it. Also the correlation among the attributes is calculated and based on this correlation, highly correlated attributes are generalized as minimum as possible by generalizing other attributes more. Therefore our approach will preserve sufficient privacy by retaining maximum amount of information from original data. Our proposed technique is theoretically analyzed and mathematical analysis surpasses earlier works with sufficient experiments.
Bridging Distributed Hash Tables in Wireless Ad-Hoc Networks

The adaptation of structured P2P networks, i.e. distributed hash tables (DHTs), to wireless ad-hoc networks has been investigated in recent years. Existing work assume all peers would come to an agreement on establishing one uniform DHT across the entire network. However, in reality, there isn't a de- facto standard of DHT implementation, different DHTs co-exist. We present a novel protocol, known as the DHT-gatewaying model, which enables cross-DHT searching between multiple DHTs of different implementations.
INFLUENCE OF EXERCISE ORDER ON THE NUMBER OF REPETITIONS PERFORMED AND PERCEIVED EXERTION DURING RESISTANCE EXERCISE IN WOMEN

The purpose of this study was to investigate the influence of different resistance exercise orders on the number of repetitions performed to failure and on the ratings of perceived exertion (RPE) in trained women. Twenty-three women with a minimum of 2 years of resistance training experience volunteered to participate in the study (age, 24.2 ± 4.5 years; weight, 56.9 ± 4.7 kg; height, 162.3 ± 5.9 cm; percent body fat, 18.2 ± 2.9%; body mass index, 22.2 ± 2 kg·m−2). Data were collected in 2 phases: (a) determination of a 1 repetition maximum (1RM) for the leg-press (LP), bench press (BP), leg extension (LE), seated machine shoulder press (SP), leg curl (LC), and seated machine triceps extension (TE); and (b) execution of 3 sets, with 2-minute rest intervals between sets and exercises, until fatigue using 80% of 1RM in 2 exercise sequences of the exact opposite order—Sequence A: BP, SP, TE, LP, LE, and LC, and Sequence B: LC, LE, LP, TE, SP, and BP. The RPE (Borg CR-10) was accessed immediately after each sequence and analyzed using a Wilcoxon test. A 2-way analysis of variance with repeated measurements, followed by a post hoc Fisher least significant difference test where indicated was used to analyze the number of repetitions per set of each exercise during the 2 sequences. The RPE was not significantly different between the sequences. The mean number of repetitions per set was always less when an exercise was performed later in the exercise sequence. The data indicate that in trained women, performance of both large- and small-muscle group exercises is affected by exercise sequence.