Miracle-dz/UniFAR-FTUs huggingface dataset:
Human Mesenchymal Stem Cells on Size-Sorted Gelatin Hydrogel Microparticles Show Enhanced In Vitro Wound Healing Activities

The demand for innovative therapeutic interventions to expedite wound healing, particularly in vulnerable populations such as aging and diabetic patients, has prompted the exploration of novel strategies. Mesenchymal stem cell (MSC)-based therapy emerges as a promising avenue for treating acute and chronic wounds. However, its clinical application faces persistent challenges, notably the low survivability and limited retention time of engraftment in wound environments. Addressing this, a strategy to sustain the viability and functionality of human MSCs (hMSCs) in a graft-able format has been identified as crucial for advanced wound care. Hydrogel microparticles (HMPs) emerge as promising entities in the field of wound healing, showcasing versatile capabilities in delivering both cells and bioactive molecules/drugs. In this study, gelatin HMPs (GelMPs) were synthesized via an optimized mild processing method. GelMPs with distinct diameter sizes were sorted and characterized. The growth of hMSCs on GelMPs with various sizes was evaluated. The release of wound healing promoting factors from hMSCs cultured on different GelMPs were assessed using scratch wound assays and gene expression analysis. GelMPs with a size smaller than 100 microns supported better cell growth and cell migration compared to larger sizes (100 microns or 200 microns). While encapsulation of hMSCs in hydrogels has been a common route for delivering viable hMSCs, we hypothesized that hMSCs cultured on GelMPs are more robust than those encapsulated in hydrogels. To test this hypothesis, hMSCs were cultured on GelMPs or in the cross-linked methacrylated gelatin hydrogel (GelMA). Comparative analysis of growth and wound healing effects revealed that hMSCs cultured on GelMPs exhibited higher viability and released more wound healing activities in vitro. This observation highlights the potential of GelMPs, especially those with a size smaller than 100 microns, as a promising carrier for delivering hMSCs in wound healing applications, providing valuable insights for the optimization of advanced therapeutic strategies.
Behavioral Characteristics of China’s NEET-Prone University Students and Graduates: A Survey from Southwest China

The NEET phenomenon (not in education, employment or training) has significant implications, both for individuals and society at large. While China’s higher education students are particularly susceptible to becoming NEET, relatively little attention has been given to understanding this issue. To address this research gap and contribute to the study of NEET in China, this paper collected a total of 12,616 samples from current higher education students and those who graduated within the past three years from universities in seven provinces of Southwest China, finding that 21.91% of the students surveyed fall into the NEET-prone student category. The underlying factors contributing to NEET-prone status are identified through logit regression analysis and categorized into three levels: individual, family, and society. At the individual level, factors such as personal ability, confidence in job-hunting, and attitude towards NEET significantly influence a student’s likelihood of being NEET-prone. Family-level factors include being an only child, consumption level, economic dependence on family members, and the presence of NEET relatives. And social-level factors encompass school provision (or non-provision) of employment services, the number of employment services offered, and the possibility of obtaining loans from society. Finally, this paper concludes by offering recommendations, which are drawn from individual, family, and social perspectives, to help Chinese higher education students avoid NEET status.
Assessing the association of drought indicators to impacts: the results for areas burned by wildfires in Portugal

In the FP7 European project “DROUGHT-R&SPI Fostering European Drought Research and Science-Policy Interfacing” CEABN works together with partners from other eight countries on monitoring and prediction tools to manage drought impacts at different scales. The wildfire extent was one of the impacts studied in relation to recent drought events in Portugal. The identification of specific periods where shortage of water is relevant to the extent of wildfires is of prime importance to counteract drought impacts. Meteorological droughts can be characterized using indices such as SPI (Standardized Precipitation Index). In this study we explored the links between area burned by wildfires and meteorological drought indicators using data series from mainland Portugal. Significant correlations were found between wildfire burned area and drought indices (SPIs 1, 3 and 6), which can be useful to understand and manage the risk of forest fires.
A NEW SPECIES OF Leucopholis zollantans sp. n. (Coleoptera: Scarabaeidae: Melolonthinae) FROM BENGKULU CITY, SUMATERA ISLAND, INDONESIA

Leucopholis zollantans, a new species of the genus Leucopholis is described from Bengkulu, Sumatera Island, Indonesia. The adult beetle captured while it was eating the mango flowers during early hours of the night at Padang Harapan Village, Bengkulu City. Diagnostic character illustrations included.
S100A8 is a prognostic signature and associated with immune response in diffuse large B-cell lymphoma

Background S100A8, a calcium-binding protein belonging to the S100 family, is involved in immune responses and multiple tumor pathogens. Diffuse large B-cell lymphoma (DLBCL) is one of the most common types of B-cell lymphoma and remains incurable in 40% of patients. However, the role of S100A8 and its regulation of the immune response in DLBCL remain unclear. Methods The differential expression of S100A8 was identified via the GEO and TCGA databases. The prognostic role of S100A8 in DLBCL was calculated using the Kaplan-Meier curve. The function enrichment of differentially expressed genes (DEGs) was explored through GO, KEGG, GSEA, and PPI analysis. In our cohort, the expression of S100A8 was verified. Meanwhile, the biological function of S100A8 was applied after the inhibition of S100A8 in an in vitro experiment. The association between S100A8 and immune cell infiltration and treatment response in DLBCL was analyzed. Results S100A8 was significantly overexpressed and related to a poor prognosis in DLBCL patients. Function enrichment analysis revealed that DEGs were mainly enriched in the IL-17 signaling pathway. Our cohort also verified this point. In vitro experiments suggested that inhibition of S100A8 should promote cell apoptosis and suppress tumor growth. Single-cell RNA sequence analysis indicated that S100A8 might be associated with features of the tumor microenvironment (TME), and immune infiltration analyses discovered that S100A8 expression was involved in TME. In terms of drug screening, we predicted that many drugs were associated with preferable sensitivity. Conclusion Elevated S100A8 expression is associated with a poor prognosis and immune infiltration in DLBCL. Inhibition of S100A8 could promote cell apoptosis and suppress tumor growth. Meanwhile, S100A8 has the potential to be a promising immunotherapeutic target for patients with DLBCL.
Fundamentos de Marketing

Fundamentos del Marketing familiariza al lector con los conceptos basicos del marketing, incluyendo, la investigacion comercial, la estrategia de marketing, y los instrumentos de la direccion de marketing (producto-consumidor, precio-coste, distribucion-conveniencia y promocion-comunicacion). Permite afrontar el aprendizaje de los contenidos con una vision holistica. Esta dividido en diez capitulos que se corresponden con tres bloques tematicos: el proceso de planificacion e investigacion comercial, los mercados, el comportamiento del consumidor y la demanda, y el diseno de estrategias. Se presentan tambien casos practicos, preguntas de repaso y los links a los resumenes a los que se puede tener acceso online, de forma gratuita.
Future of Visible Light Communication with Li-Fi Technology: A Review

Abstact-Light Fidelity (Li-Fi) refers to the 5G Visible Light Communication systems using light-emitting diodes as a medium for high-speed communication in a similar manner as Wi-Fi. [5] As now a days where internet has become a major demand, people are in a search for Wi-Fi hotspots for their activities. Li-Fi is a better alternative to Wi-Fi in wireless communication as it is [1] bidirectional, high speed and fully networked wireless communications similar to Wi-Fi. It is a subset of visible light communication(VLC) and can be a complement to RF communication , or a replacement in contexts of data broadcasting. This paper proposes a survey on Li-Fi Technology. Li-Fi has more capacity in terms of bandwidth in visible region therefore it does not interfere in other communications which uses radio frequency range, without taking its frequency bands. It has thousand times greater speed than Wi-Fi.Such technology has brought not only greener but safer and cheaper future of communication.
Does the population size of a city matter to its older adults’ self-rated health? Results of China data analysis

Clarifying the association between city population size and older adults’ health is vital in understanding the health disparity across different cities in China. Using a nationally representative dataset, this study employed Multilevel Mixed-effects Probit regression models and Sorting Analysis to elucidate this association, taking into account the sorting decisions made by older adults. The main results of the study include: (1) The association between city population size and the self-rated health of older adults shifts from a positive linear to an inverted U-shaped relationship once individual socioeconomic status is controlled for; the socioeconomic development of cities, intertwined with the growth of their populations, plays a pivotal role in yielding health benefits. (2) There is a sorting effect in older adults’ residential decisions; compared to cities with over 5 million residents, unobserved factors result in smaller cities hosting more less-healthy older adults, which may cause overestimation of health benefits in cities with greater population size. (3) The evolving socioeconomic and human-made environment resulting from urban population growth introduces health risks for migratory older adults but yields benefits for those with local resident status who are male, aged over 70, and have lower living standards and socioeconomic status. And (4) The sorting effects are more pronounced among older adults with greater resources supporting their mobility or those without permanent local resident status. Thus, policymakers should adapt planning and development strategies to consider the intricate relationship between city population size and the health of older adults.
Molecular Identification of Babesia and Theileria Infections in Livestock in the Qinghai–Tibetan Plateau Area, China

Simple Summary The Qinghai–Tibetan Plateau (QTPA), in the northwestern region of China, is characterized by diverse geographical features, earning it the title of “the roof of the world”. Despite this, limited information exists on the distribution of tick-borne pathogens in this region. This study aimed to evaluate the infection rates of Babesia and Theileria species in QTPA. Blood samples collected from livestock species (n = 366) were analyzed using different PCR-sequencing techniques. Results showed a high infection rate of Theileria spp. (38.2%). B. motasi-like Lintan/Ningxia/Tianzhu was detected in 0.3% of samples. Notably, this study reported infection rates of Babesia and Theileria species in goats, horses, and donkeys in the Qinghai–Tibetan Plateau for the first time. Abstract The northwestern region of China, known as the Qinghai–Tibet Plateau Area (QTPA), is characterized by unique climate conditions that support the breeding of various highly-adapted livestock species. Tick vectors play a significant role in transmitting Babesia and Theileria species, posing serious risks to animal health as well as the economy of animal husbandry in QTPA. A total of 366 blood samples were collected from Tibetan sheep (n = 51), goats (n = 67), yaks (n = 43), cattle (n = 49), Bactrian camels (n = 50), horses (n = 65), and donkeys (n = 40). These samples were examined using conventional and nested PCR techniques to detect Theileria and Babesia species. The overall infection rates were 0.3% (1/366) for Babesia spp. and 38.2% (140/366) for Theileria spp. Notably, neither Babesia nor Theileria species were detected in donkeys and yaks. The infection rates of Babesia and Theileria species among animals in different prefectures were significantly different (p < 0.05). Furthermore, Babesia bovis, B. bigemina, B. caballi, and B. ovis were not detected in the current study. To our knowledge, this is the first documented detection of Theileria luwenshuni infection in Bactrian camels and goats, as well as T. sinesis in cattle and T. equi in horses on the Qinghai plateau. These novel findings shed light on the distribution of Babesia and Theileria species among livestock species in QTPA.
Estimating Abundance of Seals in a Drifting Environment: 2005: Pup Production of Harp Seals, Pagophilus groenlandicus, in the Northwest Atlantic

Photographic and visual aerial surveys to determine current pup production of northwest Atlantic harp seals were conducted off Newfoundland and Labrador (the “Front”), and in the Gulf of St. Lawrence during March 2004. Surveys of four whelping concentrations were conducted between 5 and 18 March resulting in estimated pup production of 640,800 (SE=46,900, CV=7.3%) at the Front, 89,600 (SE=22,500, CV=25.4%) in the northern Gulf, and 261,000 (SE=25,700, CV=9.8%) in the southern Gulf (Magdalen Island), for a total of 991,400 (SE=58,200, CV=5.9%). Surveys were corrected for the temporal distribution of births and the mis-identification of pups by readers. Comparison with previous estimates indicates that pup production has not changed since 1999, likely due to the increased hunting of young animals which began in the mid 1990s.
Measurement and Influencing Factors of Economic Resilience over a Long Duration of COVID-19: A Case Study of the Yangtze River Delta, China

The COVID-19 pandemic put forward a new test for an economic resilience study. Its long-term and diffusive spatiotemporal characteristics suggest that we need to pay attention to the resilience and spatial heterogeneity of cities over a longer period. This paper applied SARIMA and the performance curve to measure the economic resilience of each city under the pandemic, and explored its influencing factors and spatial heterogeneity using a geodetector and geographically weighted regression model. The results show that: (1) From 2020 to 2022, the economic resilience in the Yangtze River Delta presented a downward to upward to slightly downward trend. High-resilience cities were concentrated in southern Jiangsu, while vulnerable cities were primarily located in western Anhui. The performance of regional core cities was not as strong as in previous research focusing on long-term economic resilience. (2) Fixed-asset investment, related variety, labor supply level, foreign trade dependence, and innovation level were the main influencing factors, on average. The effects of these factors had spatial heterogeneity related to the regional endowment and development quality. The findings suggest that the specificity of public health risks and the lack of coping experience may lead to a general failure of economic resilience. Identifying key factors and current weaknesses in each region can make resilience improvement strategies more targeted and effective.
General Overview of Klebsiella pneumonia: Epidemiology and the Role of Siderophores in Its Pathogenicity

Simple Summary Numerous diseases, such as liver abscesses, bacteremias, pneumonia, and urinary tract infections, are caused by Klebsiella pneumonia (K. pneumonia). Historically, immunocompromised patients have been the main target of serious infections induced by K. pneumoniae. However, with the recent appearance and dissemination of hypervirulent strains, healthy individuals have also become susceptible to infection. Moreover, treating K. pneumoniae infections is extremely difficult due to the strains’ increased antibiotic resistance. This review summarizes the various virulence factors of this bacterium, especially metallophores. The bacteriology, pathology, and epidemiology of K. pneumonia are also included in this review. Abstract The opportunistic pathogen Klebsiella pneumoniae (K. pneumoniae) can colonize mucosal surfaces and spread from mucosae to other tissues, causing fatal infections. Medical equipment and the healthcare setting can become colonized by Klebsiella species, which are widely distributed in nature and can be found in water, soil, and animals. Moreover, a substantial number of community-acquired illnesses are also caused by this organism worldwide. These infections are characterized by a high rate of morbidity and mortality as well as the capacity to spread metastatically. Hypervirulent Klebsiella strains are thought to be connected to these infections. Four components are critical to this bacterium’s pathogenicity—the capsule, lipopolysaccharide, fimbriae, and siderophores. Siderophores are secondary metabolites that allow iron to sequester from the surrounding medium and transport it to the intracellular compartment of the bacteria. A number of variables may lead to K. pneumoniae colonization in a specific area. Risk factors for infection include local healthcare practices, antibiotic use and misuse, infection control procedures, nutrition, gender, and age.
Identification and application of an exocarp-preferential promoter for genetic engineering of tomato fruit

Abstract Tomato (Solanum lycopersicum) is a globally cultivated crop with great economic value. The exocarp determines the appearance of tomato fruit and protects it from various biotic and abiotic challenges at both pre-harvest and post-harvest stages. However, no tomato exocarp-specific promoter is currently available, which hinders exocarp-based genetic engineering. Here, we identified by RNA sequencing and reverse transcription-quantitative PCR analyses that the tomato gene SlPR10 (PATHOGENESIS RELATED 10) was abundantly and predominantly expressed in the exocarp. A fluorescent reporter expressed by a 2087-bp SlPR10 promoter (pSlPR10) was mainly detected in the exocarp of transgenic tomato plants of both Ailsa Craig and Micro-Tom cultivars. This promoter was further utilized for transgenic expression of SlANT1 and SlMYB31 in tomato, which are master regulators of anthocyanin and cuticular wax biosynthesis, respectively. pSlPR10-driven SlANT1 expression resulted in anthocyanin accumulation in the exocarp, conferring gray mold resistance and extended shelf life to the fruit, while SlMYB31 expression led to waxy thickening in the fruit skin, delaying water loss and also extending fruit shelf life. Intriguingly, pSlPR10 and two other weaker tomato exocarp-preferential promoters exhibited coincided expression specificities in the gynophore of transgenic Arabidopsis (Arabidopsis thaliana) plants, providing not only an inkling of evolutionary homology between tomato exocarp and Arabidopsis gynophore but also useful promoters for studying gynophore biology in Arabidopsis. Collectively, this work reports a desirable promoter enabling targeted gene expression in tomato exocarp and Arabidopsis gynophore and demonstrates its usefulness in genetic improvement of tomato fruit quality.
Factors of Hospital Ethical Climate among Hospital Nurses in Korea: A Systematic Review and Meta-Analysis

In the current healthcare landscape, nurses frequently encounter various ethical dilemmas, necessitating situation-specific ethical judgments. It is crucial to thoroughly understand the factors that shape the hospital ethical climate and the elements that are influenced by this climate. This study aims to identify the variables associated with the hospital ethical climate perceived by Korean nurses. A literature search was conducted using the core database, and the effect sizes of relevant variables were analyzed using a comprehensive meta-analysis. The overall effect size analysis incorporated 56 variables, and a meta-analysis was performed on 7 variables. This study found correlations between ethical sensitivity (ESr = 0.48), moral distress (ESr = −0.30), empathy (ESr = 0.27), ethical leadership (ESr = 0.72), job satisfaction (ESr = 0.64), and intention to leave (ESr = −0.34) with the hospital ethical climate. Both personal and organizational attributes were moderately related to the hospital ethical climate. Enhancing the hospital ethical climate could positively affect both individuals and the organization. The protocol for this study has been registered with PROSPERO (CRD42022379812).
Feature extraction from customer reviews using enhanced rules

Opinion mining is gaining significant research interest, as it directly and indirectly provides a better avenue for understanding customers, their sentiments toward a service or product, and their purchasing decisions. However, extracting every opinion feature from unstructured customer review documents is challenging, especially since these reviews are often written in native languages and contain grammatical and spelling errors. Moreover, existing pattern rules frequently exclude features and opinion words that are not strictly nouns or adjectives. Thus, selecting suitable features when analyzing customer reviews is the key to uncovering their actual expectations. This study aims to enhance the performance of explicit feature extraction from product review documents. To achieve this, an approach that employs sequential pattern rules is proposed to identify and extract features with associated opinions. The improved pattern rules total 41, including 16 new rules introduced in this study and 25 existing pattern rules from previous research. An average calculated from the testing results of five datasets showed that the incorporation of this study’s 16 new rules significantly improved feature extraction precision by 6%, recall by 6% and F-measure value by 5% compared to the contemporary approach. The new set of rules has proven to be effective in extracting features that were previously overlooked, thus achieving its objective of addressing gaps in existing rules. Therefore, this study has successfully enhanced feature extraction results, yielding an average precision of 0.91, an average recall value of 0.88, and an average F-measure of 0.89.
Medicinal Plants against Viral Infections: A Review of Metabolomics Evidence for the Antiviral Properties and Potentials in Plant Sources

Most plants have developed unique mechanisms to cope with harsh environmental conditions to compensate for their lack of mobility. A key part of their coping mechanisms is the synthesis of secondary metabolites. In addition to their role in plants’ defense against pathogens, they also possess therapeutic properties against diseases, and their use by humans predates written history. Viruses are a unique class of submicroscopic agents, incapable of independent existence outside a living host. Pathogenic viruses continue to pose a significant threat to global health, leading to innumerable fatalities on a yearly basis. The use of medicinal plants as a natural source of antiviral agents has been widely reported in literature in the past decades. Metabolomics is a powerful research tool for the identification of plant metabolites with antiviral potentials. It can be used to isolate compounds with antiviral capacities in plants and study the biosynthetic pathways involved in viral disease progression. This review discusses the use of medicinal plants as antiviral agents, with a special focus on the metabolomics evidence supporting their efficacy. Suggestions are made for the optimization of various metabolomics methods of characterizing the bioactive compounds in plants and subsequently understanding the mechanisms of their operation.