Miracle-dz/UniFAR-FTUs huggingface dataset:
Retrospective review of positron emission tomography with contrast-enhanced computed tomography in the posttreatment setting in human papillomavirus-associated oropharyngeal carcinoma.

OBJECTIVE To determine the value of positron emission tomography (PET) with contrast-enhanced computed tomography (CT) in assessing the need for neck dissection by retrospectively reviewing the pathology reports of patients with human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (SCC). DESIGN Retrospective cohort study. SETTING Tertiary medical center. PATIENTS Seventy-seven patients with HPV-related SCC. MAIN OUTCOME MEASURES Seventy-seven consecutive patients with a diagnosis of HPV-related SCC who were treated with radiotherapy as the primary treatment between August 2007 and October 2010 were retrospectively evaluated for radiologic and pathologic rate of persistence of nodal metastasis after completion of definitive radiotherapy. Pretreatment and posttreatment imaging included contrast-enhanced CT and PET. Response to treatment was measured on CT, PET at standardized uptake value (SUV) thresholds of 2 and 2.5, and PET/CT by a neuroradiologist in a blinded fashion. Then, the pathology report of the patients who underwent neck dissections was reviewed for nodal status after resection and correlated with the imaging findings. RESULTS Of the 77 patients, 67 met the study criteria, with an average follow-up PET/CT scan at 90.5 days after completion of radiotherapy. Ten patients did not undergo follow-up PET/CT imaging. Twenty patients underwent neck dissections after completion of radiation therapy. Of these 20 patients, 4 had persistent tumor and 16 did not have viable tumor. Using the final pathology report to correlate with imaging responses, CT had a negative predictive value (NPV) of 85.7% (95% CI, 48.7%-97.4%), PET with SUV thresholds of 2 had an NPV of 91.7% (95% CI, 64.6%-98.5%), PET with a cutoff SUV of 2.5 had an NPV of 85.7% (95% CI, 60.1%-96.0%), PET/CT with an SUV of 2 had an NPV of 100% (95% CI, 59.8%-100.0%), and PET/CT with an SUV of 2.5 had an NPV of 85.7% (95% CI, 48.7%-97.4%). The 47 patients who did not undergo neck dissection had a median follow-up of 26 months without an isolated neck failure. Analysis of all 67 patients in the cohort revealed the following values: CT had an NPV of 95.7% (95% CI, 85.8%-98.8%), PET with an SUV of 2 had an NPV of 98.2% (95% CI, 90.4%-99.7%), PET with an SUV of 2.5 had an NPV of 95.0% (95% CI, 86.3%-98.3%), PET/CT with an SUV of 2 had an NPV of 100.0% (95% CI, 92.0%-100.0%), and PET/CT with an SUV of 2.5 had an NPV of 95.7% (95% CI, 85.8%-98.8%). CONCLUSIONS Positron emission tomography combined with contrast-enhanced CT has a better NPV than either imaging modality alone in patients with HPV-associated oropharyngeal SCC. Furthermore, PET/CT with an SUV threshold of 2 used in patients with HPV-related SCC offers an imaging modality with a high NPV that may obviate the need for unnecessary neck dissections.
The consequences of human actions on risks for infectious diseases: a review

The human population is growing, requiring more space for food production, and needing more animals to feed it. Emerging infectious diseases are increasing, causing losses in both human and animal lives, as well as large costs to society. Many factors are contributing to disease emergence, including climate change, globalization and urbanization, and most of these factors are to some extent caused by humans. Pathogens may be more or less prone to emergence in themselves, and rapidly mutating viruses are more common among the emerging pathogens. The climate-sensitive vector-borne diseases are likely to be emerging due to climate changes and environmental changes, such as increased irrigation. This review lists the factors within pathogens that make them prone to emergence, and the modes of transmission that are affected. The anthropogenic changes contributing to disease emergence are described, as well as how they directly and indirectly cause either increased numbers of susceptible or exposed individuals, or cause increased infectivity. Many actions may have multiple direct or indirect effects, and it may be difficult to assess what the consequences may be. In addition, most anthropogenic drivers are related to desired activities, such as logging, irrigation, trade, and travelling, which the society is requiring. It is important to research more about the indirect and direct effects of the different actions to understand both the benefits and the risks.
Spectral Tuning of Photoactive Yellow Protein †

We report a theoretical study on the optical properties of a small, water‐soluble photosensory receptor, photoactive yellow protein (PYP). A hierarchical ab initio molecular orbital calculation accurately evaluated the optical absorption maximum of the wild‐type, as well as the λmax values of 12 mutants. Electronic excitation of the chromophore directly affects the electronic state of nearby atoms in the protein environment. This effect is explicitly considered in the present study. Furthermore, the spectral tuning mechanism of PYP was investigated at the atomic level.
Pediatric Disorders with Autonomic Dysfunction: What Role for PHOX2B?

Hirschsprung disease, neuroblastomas, and congenital central hypoventilation syndrome can occur in combination, and familial cases have been reported in all three conditions. This suggests variable expression of a single genetic abnormality as the common cause to these neural crest disorders. Because the PHOX2B gene is pivotal in the development of most relays of the autonomic nervous system, including all autonomic neural crest derivatives, it was considered a candidate gene for the above conditions. Recent studies have shown that 1) PHOX2B is the main disease-causing gene for congenital central hypoventilation syndrome, an autosomal dominant disorder with incomplete penetrance; 2) PHOX2B is the first gene for which germline mutations have been demonstrated to predispose to neuroblastoma; and 3) Hirschsprung disease was associated with an intronic single-nucleotide polymorphism of the PHOX2B gene in a case-control study. For clarifying the variable clinical expression of the autonomic nervous system dysfunction observed in neural crest disorders, international databases of clinical symptoms and molecular test results should be established. Furthermore, the development of genetic mouse models should help to improve our understanding of the molecular mechanisms underlying neural crest disorders.
Comparison of norepinephrine-dobutamine to epinephrine for hemodynamics, lactate metabolism, and organ function variables in cardiogenic shock. A prospective, randomized pilot study*

Objective:There is no study that has compared, in a randomized manner, which vasopressor is most suitable in optimizing both systemic and regional hemodynamics in cardiogenic shock patients. Hence, the present study was designed to compare epinephrine and norepinephrine-dobutamine in dopamine-resistant cardiogenic shock. Design:Open, randomized interventional human study. Setting:Medical intensive care unit in a university hospital. Patients:Thirty patients with a cardiac index of <2.2 L/min−1/m−2 and a mean arterial pressure of <60 mm Hg resistant to combined dopamine-dobutamine treatment and signs of shock. Patients were not included in cases of cardiogenic shock secondary to acute ischemic events such as myocardial infarction. Noninclusion criteria also included immediate indication of mechanical assistance. Interventions:Patients were randomized to receive an infusion of either norepinephrine-dobutamine or epinephrine titrated to obtain a mean arterial pressure of between 65 and 70 mm Hg with a stable or increased cardiac index. Main Results:Both regimens increased cardiac index and oxygen-derived parameters in a similar manner. Patients in the norepinephrine-dobutamine group demonstrated heart rates lower (p < .05) than those in the epinephrine group. Epinephrine infusion was associated with new arrhythmias in three patients. When compared to baseline values, after 6 hrs, epinephrine infusion was associated with an increase in lactate level (p < .01), whereas this level decreased in the norepinephrine-dobutamine group. Tonometered PCO2 gap, a surrogate for splanchnic perfusion adequacy, increased in the epinephrine-treated group (p < .01) while decreasing in the norepinephrine group (p < .01). Diuresis increased in both groups but significantly more so in the norepinephrine-dobutamine group, whereas plasma creatinine decreased in both groups. Conclusions:When considering global hemodynamic effects, epinephrine is as effective as norepinephrine-dobutamine. Nevertheless, epinephrine is associated with a transient lactic acidosis, higher heart rate and arrhythmia, and inadequate gastric mucosa perfusion. Thus, the combination norepinephrine-dobutamine appears to be a more reliable and safer strategy.
Complete Transposition of the Great Arteries: Patterns of Congenital Heart Disease in Familial Precurrence

Background—Transposition of the great arteries (TGA) is considered to be associated only rarely with genetic syndromes and to have a low risk of precurrence among relatives of affected patients. Because most family studies have involved a relatively small number of patients and evaluated all types of TGA as a single group, we performed a large, prospective study investigating the precurrence of congenital heart disease in families of children with complete, nonsyndromic TGA. Methods and Results—From January 1997 through December 2000, 370 patients with nonsyndromic, complete TGA were consecutively evaluated and enrolled in the study. The occurrence of cardiac and noncardiac anomalies among relatives of the probands was investigated. Relatives with congenital heart disease were found in 37 of 370 families (10%), including 5 of 37 families (13.5%) with more than one affected relative. TGA itself was the most common precurrent malformation: complete TGA occurred in 6 families and congenitally corrected TGA occurred in 5 families. Precurrence risks for congenital heart disease were calculated at 1.8% (8 of 436) for siblings, 0.5% (4 of 740) for parents, 0.5% (16 of 3261) for first cousins, 0.2% (4 of 2101) for uncles/aunts, and 0.06% (1 of 1480) for grandparents. Conclusions—The present study shows that TGA is not always sporadic in families. Precurrence of concordant cardiac defects within affected family members supports monogenic or oligogenic inheritance of TGA in certain kindreds. Moreover, the occurrence of complete TGA and congenitally corrected TGA among first-degree relatives in several different families strongly suggests an underlying pathogenetic link between these 2 malformations that has been previously unrecognized.
A Study of Deep Learning Robustness Against Computation Failures

For many types of integrated circuits, accepting larger failure rates in computations can be used to improve energy efficiency. We study the performance of faulty implementations of certain deep neural networks based on pessimistic and optimistic models of the effect of hardware faults. After identifying the impact of hyperparameters such as the number of layers on robustness, we study the ability of the network to compensate for computational failures through an increase of the network size. We show that some networks can achieve equivalent performance under faulty implementations, and quantify the required increase in computational complexity.
Needs of the elderly for “elderly-aiming” products: From the view of gerontechnology

In order to clarify the needs of the elderly for “elderly-aiming” products, a questionnaire survey and an experimental study were carried out. A questionnaire survey showed that features which contribute to facilitate use of the essential function of each product were required. In the experimental study, in addition to subjective evaluation of features of an “elderly-aiming” radio, behavior and eye movements of the participants were recorded while looking at the brochure of the radio and trying it. The results showed that the elderly take account of features which enhance their declined functions due to aging process. If such features lead further difficulties, they are no longer important for the elderly users.
Unusual particle motions in the liquid crystal phases

The motions of particles dispersed in liquid crystals can be influenced by the application of an electric field, the effect depending on the field frequency and field amplitude. Sandwich cells under the application of electric field are widely used as the tool in order to investigate the fundamental research relating to electro-optic display technology. Therefore, the aim of this experimental work is to find and investigate novel motion of the particles dispersed in the liquid crystal phases, held within a sandwich cell.For the liquid crystal? particle systems in the sandwich cells in this thesis, the particle shapes, temperature and cell geometry are all shown to have an influence on the regime of the particle? s motions, with different phenomena observed using three different phases of liquid crystals. The experiments are designed to find and investigate the novel motion of the micron sized silica particles in the liquid crystal phases. In the chiral nematic phase, spherical particles are shown to exhibit linear motion, which is related to the electrophoretic mobility. Such spherical particles are also observed to show circular motion which is found to have a field dependency that can be related to Quincke rotation. A maximum frequency for motion occurs which is found to possibly be related to the effect of the ion diffusion in the liquid crystal-particle composite system. The direction of the circular motion is found to be independent of the handedness of the chiral nematic material.In the isotropic phase of a chiral nematic liquid crystal, the spherical particles do not exhibit any linear motion, which shows the system does not follow the traditional electrophoresis observed in normal isotropic liquids. The circular motion of the spherical particle that is observed in the isotropic phase is analysed in terms of the Quincke rotation and again shows the Maxwell relaxation time.The electric-field induced motion of elongated particles in four different nematic systems is examined. In this case of planar aligned systems, linear motion is observed, in which the velocity shows a minimum for particles of the same length as the cell gap. A novel field-induced defect texture appears in the homeotropic device containing a nematic liquid crystal of negative dielectric anisotropy. Interestingly, the motion of the particle is found to be strongly coupled with the defects formed.
Functional Genomic Analysis of the AUXIN RESPONSE FACTOR Gene Family Members in Arabidopsis thaliana: Unique and Overlapping Functions of ARF7 and ARF19w⃞

The AUXIN RESPONSE FACTOR (ARF) gene family products, together with the AUXIN/INDOLE-3-ACETIC ACID proteins, regulate auxin-mediated transcriptional activation/repression. The biological function(s) of most ARFs is poorly understood. Here, we report the identification and characterization of T-DNA insertion lines for 18 of the 23 ARF gene family members in Arabidopsis thaliana. Most of the lines fail to show an obvious growth phenotype except of the previously identified arf2/hss, arf3/ett, arf5/mp, and arf7/nph4 mutants, suggesting that there are functional redundancies among the ARF proteins. Subsequently, we generated double mutants. arf7 arf19 has a strong auxin-related phenotype not observed in the arf7 and arf19 single mutants, including severely impaired lateral root formation and abnormal gravitropism in both hypocotyl and root. Global gene expression analysis revealed that auxin-induced gene expression is severely impaired in the arf7 single and arf7 arf19 double mutants. For example, the expression of several genes, such as those encoding members of LATERAL ORGAN BOUNDARIES domain proteins and AUXIN-REGULATED GENE INVOLVED IN ORGAN SIZE, are disrupted in the double mutant. The data suggest that the ARF7 and ARF19 proteins play essential roles in auxin-mediated plant development by regulating both unique and partially overlapping sets of target genes. These observations provide molecular insight into the unique and overlapping functions of ARF gene family members in Arabidopsis.
Research on the system development of product design based on axiomatic design theory

Axiomatic Design, as a scientific approach has demonstrated its strength in the fields of vehicles, aircrafts, manufacturing facilities, and so on. The use of Axiomatic Design theory, together with traditional software development methodology, can improve effectively product design process. In this paper, the system development method of product design based on Axiomatic Design theory is proposed. The Axiomatic Design theory, Axiomatic Design process model, system software development process, software design structure and Object-Oriented design method are introduced in details. Finally, the system development of lathe design based on axiomatic design theory on the platform UG NX 5.0 software is presented. Application example shows that the method can greatly shorten the product development cycle, and can obtain effectively innovative products with high quality.
Specific and nonspecific inhibition of adhesion of oral actinomyces and streptococci to erythrocytes and polystyrene by caseinoglycopeptide derivatives

Various caseinoglycopeptide derivatives prepared from mammalian milk were evaluated as inhibitors of hemagglutinations mediated by Actinomyces viscosus Ny1, Streptococcus sanguis OMZ9, and, for comparative purposes, plant lectins from Arachis hypogaea and Bauhinia purpurea. It was found that recognition of the beta-D-galactose-(1----3)-2-acetamido-2-deoxy-D-galactose carbohydrate chain by Actinomyces viscosus Ny1 organisms and Arachis hypogaea and B. purpurea agglutinins had similar structural requirements; in all cases, the desialylated bovine caseinoglycomacropeptide, on which several units of the above mentioned disaccharide are clustered, behaved as the most potent hemagglutination inhibitor. By contrast, none of the preparations tested inhibited erythrocyte agglutination by S. sanguis OMZ9. Thus, the desialylated bovine caseinoglycomacropeptide acts as a potent and specific inhibitor of oral Actinomyces adhesion to cell membranes (a soft surface) and could be used as a probe for the study of recognition mechanisms mediated by Actinomyces galactose-binding lectins. During the present study, both native and desialylated variants of the same bovine glycomacropeptide also totally prevented the adhesion of Actinomyces viscosus Ny1, S. sanguis OMZ9, and S. mutans OMZ176 to polystyrene surfaces. Comparative evaluations of various structurally different compounds gave the following results. Neither mono- nor disaccharides related to caseinoglycopeptide carbohydrates prevented adhesion; highly positively or negatively charged polypeptides and polysaccharides were either not or only moderately active. Besides these glycomacropeptides, an inhibitory activity was also exhibited by other mucin-type glycoproteins carrying short O-linked carbohydrate chains (including bovine submaxillary mucin), polyethylene glycol, and bovine serum albumin. Consequently, caseinoglycopeptide prevention of oral bacterial adhesion to polystyrene tubes (a hard surface) takes place with no species specificity and can be compared to nonspecific inhibition exhibited by various polymers with very different structural characteristics.
To MIMO or Not To MIMO in Mobile Satellite Broadcasting Systems

This letter studies the potential capacity advantages of introducing a dual polarization per beam paradigm instead of the conventional single polarization per beam in mobile satellite broadcasting systems. This enables the application of MIMO techniques, not yet thoroughly investigated for mobile satellite systems. We engage in a fair system performance comparison between single polarization SISO and dual polarization non-MIMO and MIMO configurations based on the DVB-SH state-of-the-art mobile satellite standard. Along the course, the major advantages and pitfalls of a dual polarization per beam system from an interference, antenna, payload, and capacity perspective are highlighted.
Psychophysiological Reactivity in Child Sexual Abuse

ABSTRACT Sexual abuse has physiological and emotional implications. The purpose of this study is to evaluate the neurobiological sequels of childhood sexual trauma by monitoring physiological variables among sexually abused girls and women compared to controls. We assessed posttrauma and traumatic life events of 35 females sexually abused in their childhood (age range 7–51 years) and 25 control females (age range 7–54 years). Electroencephalography, frontalis electromyography, electrodermal activity, and heart rate parameters were recorded while watching sets of pictures representing neutral and trauma-suggestive stimuli. A minority of participants met the Diagnostic and Statistical Manual of Mental Disorders criteria for post-traumatic stress disorder. Abused females displayed significant elevations in heart rate, electromyography, and electroencephalography while viewing allusive stimuli and elevated heart rate while viewing neutral stimuli. The dysfunctional regulation of the physiological stress system associated with child sexual abuse may endanger the victims with various stress and anxiety disorders.
Thermoresponsive poly(N-isopropylacrylamide-co-N-vinylimidazole) hydrogels by redox polymerization

Thermoresponsive hydrogels in the form of rods were prepared from N-isopropylacrylamide (NIPAM) and N-vinylimidazole (NIV) by a redox copolymerization method. Poly(NIPAM-co-NVI) hydrogels with different thermoresponsive properties were obtained by changing the initial NIPAM/NVI mole ratio and total monomer concentrations. Equilibrium swelling ratio, dynamic swelling ratio, and dynamic deswelling ratio were evaluated for all hydrogels systems. © 2003 Wiley Periodicals, Inc. Adv Polym Techn 22: 246–251, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/adv.10053
Designing information flow policies for Android's operating system

A mobile phone evolves as a data repository where the pieces of data have different owners and may thus be protected by different security policies. These pieces of data are used on an open environment controlled by a non-specialist user: the owner of the mobile phone. However, previous research projects have studied dynamic monitoring of information flows in a system. We believe that the results of these projects are well adapted for protecting information on an embedded system as a mobile phone. Nevertheless the difficulties to define the information flow policy that govern the information flow monitor is an obstacle for the usability of such an approach by a wide audience. In this paper we detail step by step the construction of a precise information flow policy for the Android operating system. Our main objective is to answer the following questions: in practice, how much sensitive information can be monitored on a real system? What information it is desirable to monitor on a mobile phone? What is the induced execution overhead for applications? Can we propose a default information flow policy?