Miracle-dz/UniFAR-FTUs huggingface dataset:
Accounting for roaming users on mobile data access: issues and root causes

In this paper, we study how mobility affects mobile data accounting, which records the usage volume for each roaming user. We find out that, current 2G/3G/4G systems have well-tested mobility support solutions and generally work well. However, under certain biased, less common yet possible scenarios, accounting gap between the operator's log and the user's observation indeed exists. The gap can be as large as 69.6% in our road tests. We further discover that the root causes are diversified. In addition to the no-signal case reported in the prior work [23], they also include handoffs, as well as insufficient coverage of hybrid 2G/3G/4G systems. Inter-system handoffs (that migrate user devices between radio access technologies of 2G, 3G, and 4G) may incur non-negligible accounting discrepancy.
Effects of Feeding Spodoptera littoralis on Lima Bean Leaves. I. Membrane Potentials, Intracellular Calcium Variations, Oral Secretions, and Regurgitate Components1

Membrane potentials (Vm) and intracellular calcium variations were studied in Lima bean (Phaseolus lunatus) leaves when the Mediterranean climbing cutworm (Spodoptera littoralis) was attacking the plants. In addition to the effect of the feeding insect the impact of several N-acyl Glns (volicitin, N-palmitoyl-Gln, N-linolenoyl-Gln) from the larval oral secretion was studied. The results showed that the early events upon herbivore attack were: a) a strong Vm depolarization at the bite zone and an isotropic wave of Vm depolarization spreading throughout the entire attacked leaf; b) a Vm depolarization observed for the regurgitant but not with volicitin {N-(17-hydroxy-linolenoyl)-Gln} alone; c) an enhanced influx of Ca2+ at the very edge of the bite, which is halved, if the Ca2+ channel blocker Verapamil is used. Furthermore, the dose-dependence effects of N-acyl Gln conjugates-triggered influx of Ca2+ studied in transgenic aequorin-expressing soybean (Glycine max) cells, showed: a) a concentration-dependent influx of Ca2+; b) a configuration-independent effect concerning the stereochemistry of the amino acid moiety; c) a slightly reduced influx of Ca2+ after modification of the fatty acid backbone by functionalization with oxygen and; d) a comparable effect with the detergent SDS. Finally, the herbivore wounding causes a response in the plant cells that cannot be mimicked by mechanical wounding. The involvement of Ca2+ in signaling after herbivore wounding is discussed.
Antifungal activity of osthol in vitro and enhancement in vivo through Eudragit S100 nanocarriers

ABSTRACT In vitro interaction of osthol (Ost) and fluconazole (FLC) was investigated against 11 fluconazole-resistant clinical isolates of Candida albicans. Synergistic activities were determined using the checkerboard microdilution assay. The results of agar diffusion test confirmed the synergistic interaction. We used an enteric material Eudragit S100 for preparation of Ost nanoparticle (Ost-NP) to improve the oral bioavailability, biological activity of Ost. The physicochemical characteristics of Ost-S100-NP revealed Ost-S100-NP with mean particle size of 55.4±0.4 nm, encapsulation efficiency of 98.95±0.06%, drug loading efficiency of 23.89±0.25%, yield of 98.5±0.1% and a polydispersity index (PDI) of 0.165. As the Ost concentration-time curve showed, Ost-S100-NP can increase the plasma concentration and relative bioavailability of Ost compared with Ost-suspension by oral administration. In vivo, Ost-S100-NP enhanced the therapeutic efficacy of Ost against FLC-resistant C. albicans in immunosuppressed candidiasis mice model. The available information strongly suggests that Ost-S100-NP may be used as a promising compound against drug-resistant fungi.
Direct (Hetero)Arylation Polymerization of a Spirobifluorene and a Dithienyl-Diketopyrrolopyrrole Derivative: New Donor Polymers for Organic Solar Cells

The synthesis and preliminary evaluation as donor material for organic photovoltaics of the poly(diketopyrrolopyrrole-spirobifluorene) (PDPPSBF) is reported herein. Prepared via homogeneous and heterogeneous direct (hetero)arylation polymerization (DHAP), through the use of different catalytic systems, conjugated polymers with comparable molecular weights were obtained. The polymers exhibited strong optical absorption out to 700 nm as thin-films and had appropriate electronic energy levels for use as a donor with PC70BM. Bulk heterojunction solar cells were fabricated giving power conversion efficiencies above 4%. These results reveal the potential of such polymers prepared in only three steps from affordable and commercially available starting materials.
C3: A Parallel Model for Coarse-Grained Machines

Abstract In this paper, we propose a model for parallel computation, the C 3 -model. The C 3 -model evaluates, for a given parallel algorithm and target architecture, the complexity of computation , the pattern of communication , and the potential congestion arising during communication. A metric for estimating the effect of link and processor congestion on the performance of a communication operation is developed. This metric allows the evaluation of arbitrary communication operations without the user having to specify fine scheduling details. We describe how the C 3 -model can serve as a platform for the development of coarse-grained algorithms sensitive to the parameters of a parallel machine. The initial validation of the C 3 -model is discussed for the Intel Touchstone Delta. We compare predicted and actual performance of different solutions for communication operations and of various divide-and-conquer approaches for contour ranking on images.
Ready for HIT Innovations? Developing a Tool to Assess the Professionalism of Information Management in Hospitals

Current frameworks postulate the success of health IT innovations to be determined by the professionalism of the information management (PIM). Still, empirical knowledge about PIM is scarce up until today. This study seeks to answer three research questions: (1.) How can PIM be measured in a reliable and valid way, (2.) how pronounced is PIM in German hospitals and (3.) do hospital characteristics have an impact on the degree of PIM? Based on the results of an expert workshop and frameworks for information management (IM) items for a PIM inventory were developed and the inventory sent to 1349 chief information officers of German hospitals. A principle component analysis based on the responses of 196 hospitals confirmed the three components that had been proposed by the frameworks: the strategic, the tactical and the operational level. The full inventory implied satisfying reliability and allowed a PIM composite-score to be calculated. The PIM scores for strategic and tactical IM were found to be far lower than for operational IM which hints at strong deficits in these areas. A stepwise regression model indicated that the degree of PIM significantly increased with the size of the hospital, which had been expected and hints the validity of the PIM inventory. This tool offers potentials for hospitals to classify and improve their IM.
Direct Solution of the Chemical Master Equation Using Quantized Tensor Trains

The Chemical Master Equation (CME) is a cornerstone of stochastic analysis and simulation of models of biochemical reaction networks. Yet direct solutions of the CME have remained elusive. Although several approaches overcome the infinite dimensional nature of the CME through projections or other means, a common feature of proposed approaches is their susceptibility to the curse of dimensionality, i.e. the exponential growth in memory and computational requirements in the number of problem dimensions. We present a novel approach that has the potential to “lift” this curse of dimensionality. The approach is based on the use of the recently proposed Quantized Tensor Train (QTT) formatted numerical linear algebra for the low parametric, numerical representation of tensors. The QTT decomposition admits both, algorithms for basic tensor arithmetics with complexity scaling linearly in the dimension (number of species) and sub-linearly in the mode size (maximum copy number), and a numerical tensor rounding procedure which is stable and quasi-optimal. We show how the CME can be represented in QTT format, then use the exponentially-converging -discontinuous Galerkin discretization in time to reduce the CME evolution problem to a set of QTT-structured linear equations to be solved at each time step using an algorithm based on Density Matrix Renormalization Group (DMRG) methods from quantum chemistry. Our method automatically adapts the “basis” of the solution at every time step guaranteeing that it is large enough to capture the dynamics of interest but no larger than necessary, as this would increase the computational complexity. Our approach is demonstrated by applying it to three different examples from systems biology: independent birth-death process, an example of enzymatic futile cycle, and a stochastic switch model. The numerical results on these examples demonstrate that the proposed QTT method achieves dramatic speedups and several orders of magnitude storage savings over direct approaches.
Oxidative Damage of U937 Human Leukemic Cells Caused by Hydroxyl Radical Results in Singlet Oxygen Formation

The exposure of human cells to oxidative stress leads to the oxidation of biomolecules such as lipids, proteins and nuclei acids. In this study, the oxidation of lipids, proteins and DNA was studied after the addition of hydrogen peroxide and Fenton reagent to cell suspension containing human leukemic monocyte lymphoma cell line U937. EPR spin-trapping data showed that the addition of hydrogen peroxide to the cell suspension formed hydroxyl radical via Fenton reaction mediated by endogenous metals. The malondialdehyde HPLC analysis showed no lipid peroxidation after the addition of hydrogen peroxide, whereas the Fenton reagent caused significant lipid peroxidation. The formation of protein carbonyls monitored by dot blot immunoassay and the DNA fragmentation measured by comet assay occurred after the addition of both hydrogen peroxide and Fenton reagent. Oxidative damage of biomolecules leads to the formation of singlet oxygen as conformed by EPR spin-trapping spectroscopy and the green fluorescence of singlet oxygen sensor green detected by confocal laser scanning microscopy. It is proposed here that singlet oxygen is formed by the decomposition of high-energy intermediates such as dioxetane or tetroxide formed by oxidative damage of biomolecules.
Physical symbol grounding and instance learning through demonstration and eye tracking

It is natural for humans to work with abstract plans which are often an intuitive and concise way to represent a task. However, high level task descriptions contain symbols and concepts which need to be grounded within the environment if the plan is to be executed by an autonomous robot. The problem of learning the mapping between abstract plan symbols and their physical instances in the environment is known as the problem of physical symbol grounding. In this paper, we propose a framework for Grounding and Learning Instances through Demonstration and Eye tracking (GLIDE). We associate traces of task demonstration to a sequence of fixations which we call fixation programs and exploit their properties in order to perform physical symbol grounding. We formulate the problem as a probabilistic generative model and present an algorithm for computationally feasible inference over the proposed model. A key aspect of our work is that we estimate fixation locations within the environment which enables the appearance of symbol instances to be learnt. Instance learning is a crucial ability when the robot does not have any knowledge about the model or the appearance of the symbols referred to in the plan instructions. We have conducted human experiments and demonstrate that GLIDE successfully grounds plan symbols and learns the appearance of their instances, thus enabling robots to autonomously execute tasks in initially unknown environments.
The interplay between T helper subset cytokines and IL‐12 in directing human B lymphocyte differentiation

This study asks how T helper (TH) subset cytokines impact upon IL‐12‐directed change in B cells engaged in signaling via the B cell receptor and CD40, essential components in the initiation of T‐dependent B cell responses. For B cells stimulated in this way, IL‐12 promoted a distinct phenotype highlighted by the hyper‐expression of CD38: the Th1 cytokine IFN‐γ reproduced the IL‐12 effects while neutralizing antibody to IFN‐γ reversed IL‐12‐dependent change. The divergent pathway of differentiation promoted by the Th2 cytokine IL‐4 (characterized by hyper‐induction of CD23) was left unchecked by IL‐12. IL‐10 was found to dampen IL‐12 actions by suppressing IL‐12‐dependent IFN‐γ production but failed to perturb the effects of exogenous IFN‐γ. Thus, IL‐12 – by invoking autocrine IFN‐γ production – promotes phenotypic deviation in B cells engaging T‐dependent signals. The reversal of such Th1 driving of B cells by IL‐10 only when the source of IFN‐γ is endogenous and the inability of IL‐12 to impact upon IL‐4‐directed differentiation suggest a progressive and hierarchical commitment of B cells to polarization during a developing T‐dependent response dominated at the level of the Th cell rather than that of the dendritic cell.
Life-long spatio-temporal exploration of dynamic environments

We propose a new idea for life-long mobile robot spatio-temporal exploration of dynamic environments. Our method assumes that the world is subject to perpetual change, which adds an extra, temporal dimension to the explored space and makes the exploration task a never-ending data-gathering process. To create and maintain a spatio-temporal model of a dynamic environment, the robot has to determine not only where, but also when to perform observations. We address the problem by application of information-theoretic exploration to world representations that model the uncertainty of environment states as probabilistic functions of time. We compare the performance of different exploration strategies and temporal models on real-world data gathered over the course of several months and show that combination of dynamic environment representations with information-gain exploration principles allows to create and maintain up-to-date models of constantly changing environments.
Facilitating Dynamics of Focus Group Interviews in East Asia: Evidence and Tools by Cross-Cultural Study

Relevance to Design Practice – This study offers implications as to how a specific user research method in design should be localized in different cultural contexts. Specifically, cross-cultural experiments on focus group interviews in the Netherlands and South Korea showed differences in participants’ behaviours and attitudes. The findings from theoretical reviews and experiments in this study provide practical guidelines to conducting focus group interviews in East Asia.
Still Searching or Have You Found It Already? – Usability and Web Design of an Educational Website

Abstract Background: Apart from a straight-forward and intuitive operability an appealing design determines the success of a website equally well. For this reason, the selection of images and navigation bars plays a determining role. The eye tracking method proved to be appropriate in order to verify the usability of websites. Objectives: The aim of the study was to improve the usability of the website of an educational institute for trainees as target group. Methods/Approach: For this purpose, the use of an eye-tracking technology was combined with a survey. The eye-tracking study was implemented task-oriented. Test persons were asked to search for particular courses within this institute. Results: This approach in combination with a subsequent questionnaire resulted in tangible indications of search patterns of the test group. Furthermore, their perception and their appraisal of the usability as well as the web design was analysed. Even though most tasks were accomplished effectively and efficiently with a positive user feedback, a potential for improvement was detected, in particular with regard to the images and the location of the search field. Conclusions: The selected choice of methods enables researchers and web designers to derive recommendations for the orientation, structure, optimisation and comprehensibility of a website.
Harmonic current analysis of the active front end system in the presence of grid voltage disturbance

Prediction and control of harmonics injected into the grid from power electronics converters are very important for the power system. This paper analyzes the harmonic currents of an active front-end (AFE) system using its input admittance in the synchronous rotating frame in the presence of voltage harmonics at the point of common coupling (PCC). A voltage harmonic at the PCC of the AFE system with angular frequency of ω may induce current harmonics with angular frequency at not only ω, but also 2ω0-ω. The line angular frequency is ω0. To reduce the induced current harmonics, a grid sensitivity function defined by the grid and AFE impedances should be designed with low magnitude. The proposed analysis and method are validated using simulation and experiments.
Proteomic analysis of ametryn toxicity in zebrafish embryos

Ametrym (AMT) is the most widely used herbicide and frequently detected in the aquatic environment. AMT also represent a potential health risk to aquatic organisms and animals, including humans. However, little data are available on their toxicity to zebrafish (Danio rerio). The aim of the present study was to evaluate the toxicological effects of AMT exposure on zebrafish embryos. In the acute toxicity test, 6 hpf embryos were exposed to various concentrations of AMT for 24 or 48 h. The results indicated that AMT induced malformation in larvae. To investigate the toxicological mechanism on the protein expression level. A proteomic approach was employed to investigate the proteome alterations of zebra fish embryos exposed to 20 mg/L AMT for 48 h. Among 2925 unique proteins identified, 298 differential proteins (> or <1.3‐fold, P < 0.05) were detected in the treated embryos as compared to the corresponding proteins in the untreated embryos. Gene ontology analysis showed that these up‐regulated proteins were most involved in glycolysis, lipid transport, protein polymerization, and nucleotide binding, and the down‐regulated proteins were related to microtubule‐based process, protein polymerization, oxygen transport. Moreover, KEGG pathway analysis indicated that tight junction, ribosome, and oxidative phosphorylation were inhibited in the treated embryos. These findings provide new insight into the mechanisms of toxicity induced by AMT.
Rate-distance tradeoff and resource costs for all-optical quantum repeaters

We present a resource-performance tradeoff of an all-optical quantum repeater that uses photon sources, linear optics, photon detectors and classical feedforward at each repeater node, but no quantum memories. We show that the quantum-secure key rate has the form $R(\eta) = D\eta^s$ bits per mode, where $\eta$ is the end-to-end channel's transmissivity, and the constants $D$ and $s$ are functions of various device inefficiencies and the resource constraint, such as the number of available photon sources at each repeater node. Even with lossy devices, we show that it is possible to attain $s < 1$, and in turn outperform the maximum key rate attainable without quantum repeaters, $R_{\rm direct}(\eta) = -\log_2(1-\eta) \approx (1/\ln 2)\eta$ bits per mode for $\eta \ll 1$, beyond a certain total range $L$, where $\eta \sim e^{-\alpha L}$ in optical fiber. We also propose a suite of modifications to a recently-proposed all-optical repeater protocol that ours builds upon, which lower the number of photon sources required to create photonic clusters at the repeaters so as to outperform $R_{\rm direct}(\eta)$, from $\sim 10^{11}$ to $\sim 10^{6}$ photon sources per repeater node. We show that the optimum separation between repeater nodes is independent of the total range $L$, and is around $1.5$ km for assumptions we make on various device losses.
Influence of spatial heterogeneity on an emerging infectious disease: the case of dengue epidemics

The importance of spatial heterogeneity and spatial scales (at a village or neighbourhood scale) has been explored with individual-based models. Our reasoning is based on the Chilean Easter Island (EI) case, where a first dengue epidemic occurred in 2002 among the relatively small population localized in one village. Even in this simple situation, the real epidemic is not consistent with homogeneous models. Conversely, including contact heterogeneity on different scales (intra-households, inter-house, inter-areas) allows the recovery of not only the EI epidemiological curve but also the qualitative patterns of Brazilian urban dengue epidemic in more complex situations.
Mechanism of Pupillary Reflex Dilation in Awake Volunteers and in Organ Donors

Background The mechanism of reflex pupillary dilation was investigated in eight patients who were declared brain dead after rupture of intracranial vascular malformations and in eight awake volunteers. The authors hypothesized that the reflex was primarily a spinal sympathetic reflex that would be blocked by topical application of the &agr;1-adrenergic blocking agent dapiprazole and that it would be present in organ donors with intact spinal reflexes and no history of hypoxia. Methods In volunteers, pupil size was measured with an infrared pupillometer while brief painful electric stimuli were delivered to the finger. Pain was assessed with a visual analog scale and adjusted with each volunteer to equal 3 on a visual analog scale of 0–10. Subjects were studied before and after topical application of the &agr;1-adrenergic antagonist dapiprazole. In organ donors, the authors measured pupil size after high-intensity tetanic electric stimulation and in dapiprazole-blocked and -unblocked pupils after surgically induced nociception. Results In volunteers, the pupil dilated 0.43 ± 0.23 mm after nociceptive stimuli. Dapiprazole eyedrops blocked this dilation, confirming that the reflex in awake humans is primarily a sympathetic reflex. Baseline diameters were 5.7 ± 0.5 mm before dapiprazole and 4.1 ± 0.9 mm after dapiprazole. In organ donors, a tetanic electric current failed to dilate the pupil, whereas the skin incision dilated the pupil 0.4 ± 0.4 mm, but this dilation was not blocked by dapiprazole. Conclusion The authors conclude that pupillary reflex dilation, as it is clinically performed in awake subjects by stimulating somatic nociceptors, is a sympathetic reflex. Because it is not present in organ donors, the neural pathway must require a supraspinal component for completion.
Exploitation of Phosphate from Fertile Soil Microsites by Three Great Basin Perennials When in Competition

The effectiveness of phosphate (P) exploitation from fertile soil microsites was investigated with a dual-radioisotope approach for three perennial Great Basin species. Three experi- ments with competing species pairs assessed the ability to acquire P in fertilized and control patches. The patches occupied less than 1% 6fmthe rooted soil volume. In all experiments, the plants acquired at least as much radioisotope from the enriched as from the control patches even though the isotopes in the enriched patches were diluted by a factor of 108 with added 31P. The plants procured P from the enriched patches in propor- tion to its increased concentration relative to P in the control patches. The relative ability of the competing species to acquire P was very similar in control and enriched patches. Artemisia triden- tata (Rydb.) Beetle was able to acquire much more P than Pseudoroegneria spicata (Pursh) A. Lbve and was equivalent in ability to acquire P when in competition with Agropyron desertorum (Fisch, ex Link) Schult. However, when the Agropyron and Pseudoroegneria were together, they were unexpectedly similar in procuring P.