Miracle-dz/UniFAR-FTUs huggingface dataset:
THE APPLICATION OF APRIORI ALGORITHM FOR NETWORK FORENSICS ANALYSIS

With frequently network attack crimes, it causes serious economic loss and bad social influence. Network security products are practically impossible to guard against intrusion methods, network forensics is needed. The massive network data must be captured and analyzed in network forensics, and the data is often related, the application of Apriori algorithm is proposed for network forensics analysis. After capturing and filtering network data package, and the Apriori algorithm is used to mine the association rules according to the evidence relevance to build and update signature database of offense, current user behavior is judged legal or not through pattern match results of user behavior and association rules which are stored in databases. The crime behaviors are saved in evidence database, which can be used as primitive evidence for network forensics. Simulation results show that the application of Apriori algorithm can raise the speed, exactitude and intelligence of data analysis for network forensics, the application can help to resolve the real-time, efficient and adaptable problems in network forensics.
Autoimmune pancreatitis associated with retroperitoneal fibrosis.

CONTEXT Autoimmune pancreatitis is sometimes associated with other autoimmune diseases. We have presented two cases of autoimmune pancreatitis with retroperitoneal fibrosis and compared our findings with those found in the literature. CASE 1: A 71-year-old male developed anorexia and weight loss. Abdominal ultrasonography (US) and computed tomography (CT) showed diffuse swelling of the pancreas and the peritoneal soft tissue surrounding the aorta, associated with right hydronephrosis. Endoscopic retrograde pancreatography showed narrowing of the main pancreatic duct. He was diagnosed as having autoimmune pancreatitis associated with retroperitoneal fibrosis and underwent steroid therapy. After 3 weeks, a follow-up CT showed a marked reduction in the size of both the pancreas and retroperitoneal mass. CASE 2: A 62-year-old male was admitted to another hospital complaining of obstructive jaundice. Abdominal CT and US showed swelling of the pancreas. Endoscopic retrograde cholangiopancreatography demonstrated stenosis of the lower bile duct and narrowing of the main pancreatic duct. With the diagnosis of pancreatic head carcinoma, a choledochojejunostomy and a gastrojejunostomy were performed. Histological examination of the biopsy of the pancreatic mass revealed marked fibrosis with lymphoplasmacytic infiltration. One year later, a retroperitoneal mass was detected on follow-up CT. He was treated with prednisolone for two years. Recurrence of retroperitoneal mass with left hydronephrosis occurred 18 months later. There was no sign of recurrence of the autoimmune pancreatitis. He was again treated with prednisolone, and the retroperitoneal mass was gradually reduced. CONCLUSIONS A total of 7 cases including the present cases have been reported. All were middle-aged males. Steroid therapy was effective for both the pancreatic and the retroperitoneal masses.
Jumping into the abyss:an exploration of the concept of Organizational Burnout

Whilst the primary focus concerning burnout at work has been at individual and job level (Maslach, Demeteriou, Leiter, Schaufeli), very little academic literature or research has addressed the concept of “organization level burnout”. Within the context of continuous organizational change and heightening competitiveness at work, it could be argued that there is a greater propensity for individuals to be working within teams, divisions and possibly organizations which are suffering from burnout. This paper explores the concept of organizational burnout by outlining traditional definitions of burnout, analysing the differing levels of burnout and how these are measured at individual and job level, then extrapolating from that to an organizational level of analysis. Following that, suggestions for further research and understanding of organizational level burnout will be explored together with providing some practical managerial interventions.
Multiplatform single-sample estimates of transcriptional activation

Significance We present our Universal exPression Code (UPC) approach for deriving “barcodes,” which estimate the active/inactive state of genes in a sample. UPCs normalize for technological variance and standardize data so they can be combined across microarray and RNA-sequencing experiments with high concordance. Because our method is applied to one sample at a time and thus bypasses the need to standardize samples together, it is distinctively suitable for situations in which samples arrive serially rather than in batches. We demonstrate our method’s utility in various biomedical research applications and compare against technology-specific approaches. Over the past two decades, many biotechnology platforms have been developed for high-throughput gene expression profiling. However, because each platform is subject to technology-specific biases and produces distinct raw-data distributions, researchers have experienced difficulty in integrating data across platforms. Data integration is crucial to data-generating consortiums, researchers transitioning to newer profiling technologies, and individuals seeking to aggregate data across experiments. We address this need with our Universal exPression Code (UPC) approach, which corrects for platform-specific background noise using models that account for the genomic base composition and length of target regions; this approach also uses a mixture model to estimate whether a gene is active in a particular profiling sample. The latter produces standardized UPC values on a zero-to-one scale, so that they can be interpreted consistently, irrespective of profiling technology, thus enabling downstream analysis pipelines to be developed in a platform-agnostic manner. The UPC method can be applied to one- and two-channel expression microarrays and to next-generation sequencing data (RNA sequencing). Furthermore, UPCs are derived using information from within a given sample only—no ancillary samples are required at processing time. Thus, UPCs are suitable for personalized-medicine workflows where samples must be processed individually rather than in batches. In a variety of analyses and comparisons, UPCs perform comparably to other methods designed specifically for microarrays or RNA sequencing in most settings. Software for calculating UPCs is freely available at www.bioconductor. org/packages/release/bioc/html/SCAN.UPC. html.
Prospective study of combined colon and endometrial cancer screening in women with lynch syndrome: a patient-centered approach.

BACKGROUND Endometrial and colorectal cancers are the most common cancers in Lynch syndrome. Consensus guidelines recommend annual endometrial biopsy (EMB) and regular colonoscopies. We assessed the feasibility of concurrently performing EMB and colonoscopy and evaluated women's perception of pain, satisfaction, and acceptability. METHODS From July 2002 to December 2009, women who had a gene mutation for Lynch syndrome, met the Amsterdam II criteria, or had a high-risk situation that required screening were prospectively enrolled. After conscious sedation, the procedures were sequentially performed. Patients completed pre- and postprocedure questionnaires assessing pain, level of satisfaction, and acceptability. The Wilcoxon rank test and Mann-Whitney test were used to compare pain scores. RESULTS Forty-two women completed the study. Median age was 37 years (range, 25 to 73). Nineteen had previously had an EMB in the office setting. Women reported significantly lower median levels of pain in the combined procedure compared with previous office setting biopsies (P < .001). Regardless of parity, women reported significantly less pain for an EMB as part of the combined screen compared with an office EMB (parous, P = .003; nulliparous, P = .026). Women also reported a high level of satisfaction and more convenience in the combined procedure. All participants preferred combined to separately scheduled procedures and would recommend the combined procedure to their relatives. CONCLUSION Combined colon and endometrial cancer screening is a patient-centered approach that is feasible, acceptable, and may improve adherence to Lynch syndrome screening recommendations.
Attitudes toward Blind People among Theological and Education Students

Attitudes toward blindness among education and theological students are examined in this article, specifically the differences in attitudes toward blindness between education and seminary student groups; between conservative and liberal student groups; between first- and third-year seminary student groups; and between the sexes. Subjects were 213 graduate education students at the University of Pittsburgh and 175 graduate theological students enrolled in six selected seminaries. The Disability Factor Scales-Blindness (DFS-B) and selected items from the Polyphasic Value Inventory (PVI) were utilized. The results obtained are: Graduate education students do not differ from graduate theological students in their overall attitudes toward blindness, but education students do react more unfavorably to Rejection of Intimacy dimension; conservative students react more unfavorably to blindness than do liberal students; and students in the two conservative seminaries have more unfavorable attitudes than those in the liberal seminary; third-year seminarians indicated more definite presence of Rejection of Intimacy and Distressed Identification dimensions than first-year seminarians; and female students show more favorable reactions to blindness than do male students.
Synthesis of low-power selectively-clocked systems from high-level specification

In this paper we propose a technique for synthesizing low-power systems from a high-level specification. We analyze the control flow of the specification to detect mutually exclusive sections of the computation. A selectively-clocked interconnection of interacting FSMs is automatically generated and optimized where each FSM controls the execution of one section of computation. Only one of the interacting FSMs is active at any given clock cycle, while all the others are idle and their clock is stopped. Our interacting FSM implementation achieves consistently lower power dissipation savings are obtained with a 30% area overhead.
Carbon, nitrogen and oxygen abundances in atmospheres of the 5–11 M⊙ B-type main-sequence stars

Fundamental parameters and the carbon, nitrogen and oxygen abundances are determined for 22 B-type stars with distances up to 600 pc and slow rotation (vsini up to 66 km/s). The stars are selected according to their effective temperatures Teff and surface gravities log g, namely: Teff is between 15300 and 24100 K and log g is mostly greater than 3.75; therefore, stars with medium masses of 5-11 M are selected. Theory predicts for the stars with such parameters that the C, N and O abundances in their atmospheres should correspond to their initial values. Non-LTE analysis of C II, N II and O II lines is implemented. The following mean C, N and O abundances are obtained: log \epsilon(C) = 8.31+-0.13, log \epsilon(N) = 7.80+-0.12 and log \epsilon(O) = 8.73+-0.13. These values are in very good agreement with recent data on the C, N and O abundances for nearby B stars from other authors; it is important that different techniques are applied by us and other authors. When excluding for the stars HR 1810 and HR 2938, which can be mixed, we obtain the following mean abundances for the remaining 20 stars: log \epsilon(C) = 8.33+-0.11, log \epsilon(N) = 7.78+-0.09 and log \epsilon(O) = 8.72+-0.12; these values are in excellent agreement with a present-day Cosmic Abundance Standard (CAS) of Nieva & Przybilla.
The Acoustic Change Complex in Young Children with Hearing Loss: A Preliminary Study

Abstract The acoustic change complex (ACC) is a cortical auditory evoked potential elicited in response to a change in an ongoing sound. The ACC may have promise for assessing speech perception in infants and toddlers. In this preliminary study, the ACC was elicited in adults and young children in response to changes in speech stimuli representing vowel height /u/-/a/ and vowel place /u/-/i/ contrasts. The participants were adults with normal hearing (n = 3), children with normal hearing (n = 5), and children with mild to moderately severe bilateral sensorineural hearing loss (n = 5). The children with hearing loss were hearing aid users. The ages ranged from 2 years 3 months to 6 years 3 months for the children and 44 to 55 years for the adults. Robust P1-N1-P2 responses were present for the adults and P1-N2 responses were present for all but the youngest child with hearing loss. The ACC response for the vowel place contrast was less robust than that for the vowel height contrast in one child with substantial hearing loss. The findings from this preliminary study support the conclusion that the ACC can be used successfully to assess auditory resolution in most young children.
Coupling Unbiased Mutagenesis to High-throughput DNA Sequencing Uncovers Functional Domains in the Ndc80 Kinetochore Protein of Saccharomyces cerevisiae

During mitosis, kinetochores physically link chromosomes to the dynamic ends of spindle microtubules. This linkage depends on the Ndc80 complex, a conserved and essential microtubule-binding component of the kinetochore. As a member of the complex, the Ndc80 protein forms microtubule attachments through a calponin homology domain. Ndc80 is also required for recruiting other components to the kinetochore and responding to mitotic regulatory signals. While the calponin homology domain has been the focus of biochemical and structural characterization, the function of the remainder of Ndc80 is poorly understood. Here, we utilized a new approach that couples high-throughput sequencing to a saturating linker-scanning mutagenesis screen in Saccharomyces cerevisiae. We identified domains in previously uncharacterized regions of Ndc80 that are essential for its function in vivo. We show that a helical hairpin adjacent to the calponin homology domain influences microtubule binding by the complex. Furthermore, a mutation in this hairpin abolishes the ability of the Dam1 complex to strengthen microtubule attachments made by the Ndc80 complex. Finally, we defined a C-terminal segment of Ndc80 required for tetramerization of the Ndc80 complex in vivo. This unbiased mutagenesis approach can be generally applied to genes in S. cerevisiae to identify functional properties and domains.
Outcomes of symptomatic osteonecrosis in 95 patients with systemic lupus erythematosus.

OBJECTIVE To describe the frequency and type of symptomatic osteonecrosis (ON) in a large cohort of patients with systemic lupus erythematosus (SLE) followed in a single center and to describe the outcome in terms of mortality and disability compared to SLE patients without ON. METHODS Patients with ON were identified from the University of Toronto Lupus Clinic Database. The diagnosis of ON was confirmed by radiographs, bone scans, tomograms, or magnetic resonance images. A comparison group of patients with SLE without ON was selected from the same database, matched by year of birth, sex, and year of entry to the clinic. Mortality, disability, and health related quality of life were compared between patients with and without ON. RESULTS Ninety-nine patients with ON were identified with 217 affected joints, the majority hips and knees, often in a bilateral distribution. There was no increase in mortality. Patients with ON had higher Health Assessment Questionnaire scores and lower SF-20 scores of physical functioning, suggesting increased disability. Hip joints that underwent surgery were more likely to have higher grades of ON at diagnosis. CONCLUSION Symptomatic ON occurred in 12.8% of 744 patients with SLE and often involved multiple joints. ON was not associated with increased mortality but was associated with physical disability. Radiological class of the hip jointsat diagnosis of ON was predictive of subsequent surgery.
High bone morphogenetic protein-15 level in follicular fluid is associated with high quality oocyte and subsequent embryonic development.

BACKGROUND Bone morphogenetic protein-15 (BMP-15) has been shown to influence oocyte maturation and quality. However, no relationship has been established between BMP-15 and oocyte quality/embryonic development in humans. The aim of this study is to investigate BMP-15 level in human follicular fluid (FF) and its possible role in determining oocyte quality and developmental potential. METHODS A total of 79 oocytes and their corresponding FF from 79 women undergoing ICSI were examined. Individual oocytes were inseminated and subsequently assessed on the basis of their fertilization, cleavage and preimplantation development. BMP-15, FSH, estradiol (E(2)) and progesterone levels of FF were also analysed via the techniques of western blot or radioimmunoassay. RESULTS Higher FF BMP-15 levels were observed in the fertilized and cleaved groups versus the unfertilized and uncleaved groups, respectively (P < 0.05). The best (Grade I) embryo morphology was associated with higher FF BMP-15 levels than Grade II or III embryos (P < 0.01). A significant positive correlation was found between BMP-15 and E(2) levels in the same follicle. CONCLUSION The present study demonstrates that the BMP-15 level in FF appears to be a potential factor in predicting oocyte quality and subsequent embryo development, and is correlated with E(2) level, which may additionally be a valuable predictor of oocyte fertilization.
Diagnosis and Treatment of Extrapulmonary Tuberculosis

Extrapulmonary tuberculosis (EPTB) constitutes about 20% of all cases of tuberculosis (TB) in Korea. Diagnosing EPTB remains challenging because clinical samples obtained from relatively inaccessible sites may be paucibacillary, thus decreasing the sensitivity of diagnostic tests. Whenever practical, every effort should be made to obtain appropriate specimens for both mycobacteriologic and histopathologic examinations. The measurement of biochemical markers in TB-affected serosal fluids (adenosine deaminase or gamma interferon) and molecular biology techniques such as polymerase chain reaction may be useful adjuncts in the diagnosis of EPTB. Although the disease usually responds to standard anti-TB drug therapy, the ideal regimen and duration of treatment have not yet been established. A paradoxical response frequently occurs during anti-TB therapy. It should be distinguished from other causes of clinical deterioration. Surgery is required mainly to obtain valid diagnostic specimens and to manage complications. Because smear microscopy or culture is not available to monitor patients with EPTB, clinical monitoring is the usual way to assess the response to treatment.
Useful tools in the work of an academic teacher - how to motivate a contemporary student

The issue of motivating students to engage in the learning process is one of the most important elements in the work of an academic teacher. The article presents various forms of work with groups of students, gathered for their suitability in terms of stimulating the attention and engaging class participants. The proposed activities emphasize the need for inspiring positive motivation for learning. Another important issue is effective communication during the course and influencing a group by the use of proper communication tools by a teacher. One of the discussed issues given attention to was also the impact of specific perceptual filters used by a lecturer on the effectiveness of running a group during the class. This issue is discussed based on the Schultz von Thun four-ears model.
Phase-dependent modulation of proximal and distal postural responses to slips in young and older adults.

BACKGROUND Phase-dependent modulation of postural responses plays an important functional role in integrating reflexes into ongoing locomotion behaviors. This study tested the hypotheses that proximal and distal postural responses are modulated differently according to the phases of the gait cycle in young adults and that there is a decline in this modulatory ability with normal aging. METHODS Thirty-three healthy young adults (age = 25 +/- 4 years) and 32 healthy older adults (mean age 74 +/- 14 years) participated. Subjects walked across a movable force plate with its movement timed to heel strike or midstance to simulate a forward slip occurring at different times during the gait cycle. Surface electromyography was recorded from bilateral leg, thigh, hip, and trunk muscles. Kinematic data were collected from the right (perturbed) side of the body. RESULTS Postural responses to the heel strike slips occurred more frequently, and were of shorter latency, longer burst duration, and greater burst magnitude, than those in response to the midstance slips. Whereas the early and predominant postural responses came from bilateral tibialis anterior, rectus femoris, and biceps femoris muscles in heel strike slips, early postural responses were observed in bilateral erector spinae muscles in midstance slips. The late postural responses in midstance slips (from bilateral biceps femoris muscles and medial gastrocnemius and tibialis anterior of the nonperturbed leg) assisted in foot liftoff of the perturbed leg and earlier and safe landing with the nonperturbed leg. In response to the heel strike versus midstance slips, older adults preserved the phase-dependent modulatory abilities of the occurrence, onset latency, and burst duration of their postural responses, but not the ability to modulate burst magnitude, as compared to young adults. CONCLUSION Postural responses from the proximal and distal muscles in reaction to different temporal phasing of slips during the step cycle showed differential modulation to meet the different task requirements. Older adults preserve this modulatory ability but with limited capacity. Physiological or psychological factors may influence older adults' phase-dependent modulatory capacity.
Palbociclib and tumor suppressor gene activation

Recently in Expert Opinion on Pharmacotherapy, Steger, Gnant, and Bartsch nicely reviewed the recent studies of palbociclib involving patients with breast cancer [1]. I believe it is important to highlight that ultimately the mechanism of action with palbociclib primarily appears to involve activating a tumor suppressor gene (Rb), in contrast to the many other recently approved kinase inhibitors which typically act more exclusively by inactivating oncogenic activity. Since loss of tumor suppressor gene functions are more common gatekeeper and driver abnormalities in oncogenesis and progression than oncogenic activation, the success of palbociclib will hopefully stimulate more research aimed at developing agents which activate tumor suppressor gene products. Funding
Shadow Theory, data model design for data integration

For data integration in information ecosystems, semantic heterogeneity is a known difficulty. In this paper, we propose Shadow Theory as the philosophical foundation to address this issue. It is based on the notion of shadows in Plato's Allegory of the Cave. What we can observe are just shadows, and meanings of shadows are mental entities that only exist in viewers' cognitive structures. With enterprise customer data integration example, we proposed six design principles and algebra to support required operations.