Miracle-dz/UniFAR-FTUs huggingface dataset:
EKSPERIMENTASI MODEL PEMBELAJARAN KOOPERATIF TIPE NUMBERED HEAD TOGETHER (NHT) DENGAN ASSESSMENT FOR LEARNING (AfL) MELALUI PENILAIAN TEMAN SEJAWAT PADA MATERI PERSAMAAN GARIS DITINJAU DARI KREATIVITAS BELAJAR MATEMATIKA SISWA MTsN DI KABUPATEN SRAGEN

Abstract: This research is aimed to view: (1) which gives a better learning achievement, learning Numbered Head Together (NHT) with the AfL through peer assessment, NHT or direct learning, (2) which gives better achievement, low, medium or high level creativity in mathematics learning, (3) which has better mathematics learning achievement, student having low, medium or high learning creativity on each learning model, (4) which learning model gives better achievement in learning mathematics, learning model Numbered Head Together (NHT) with the AfL through peer assessment, learning models Numbered Head Together (NHT) or direct learning model on each student’s creativity level. This research was a quasi-experimental research with 3x3 factorial design. The study population was all students MTsN in Sragen. The sampling technique used a stratified cluster random sampling. The samples were 294 students, consisted of 95 students in the first experimental class, 100 students in the second experimental class and 99 students in the control class. Data collected through mathematics achievement tests and questionnaires of study mathematics creativity. Hypothesis testing used two- way analysis of variance with unbalanced cells. The results show as follows. (1) The NHT with the AfL through peer assessment model provide a better learning performance than the NHT and direct learning model. The NHT model provide a better learning performance than the direct learning model. (2) Students with a high level learning creativity have a better achievement than students who have medium and low creativity. Students with medium and low level creativity gain the same learning achievement. (3) In the NHT learning model with the AfL through peer assessment, students with a high level creativity gain better learning achievement than students with medium learning creativity, but when compared with students who have low learning creativity get the same academic achievement. While using NHT model and direct learning, students with high, medium and low creativity get the same learning achievement. (4) At the high level of creativity, NHT with the AfL through peer assessment model gived a better performance than the NHT and direct learning, NHT and direct learning models provide the same learning performance. Students having medium and low level of creativity provide the same learning achievement in each learning models. Keywords : NHT, AfL, peer assessment, creativity in learning.
iEAR: Immersive Environmental Audio for Photorealistic Panoramas

This paper presents iEAR, a flexible spatial audio rendering tool for use with photorealistic monoscopic and stereoscopic panoramas across various display systems. iEAR allows users to easily present multichannel audio scenes over variable speaker arrangements, while maintaining tight integration with the corresponding visual elements of the display media. Built in the Max/MSP Audio Programming Environment, iEAR utilizes well-established panning methods to accommodate a wide range of speaker configurations. Audio scene orientation is tied to the visual scene using an OSC connection with the visualization software, allowing users to render and spatialize multichannel environmental audio recordings in tandem with the changing perspective in the visual scene.
Distribution of cross-polar discrimination in Nakagami-m fading channels

In this letter, the small-scale variations of cross-polar discrimination (XPD) are shown to have a generalized Beta prime distribution in Nakagami-m fading channels. The cumulative distribution function of the distribution can be simply computed in mathematical software like MATLAB. Indoor measurements have been carried out at 2.4 GHz to validate the derived XPD model. The theoretical distribution is in good agreement with the experiment results.
The Sentencing Response to Defendants with Foetal Alcohol Spectrum Disorder

This article explores the sentencing response to defendants who have Foetal Alcohol Spectrum Disorder (FASD). FASD is the umbrella term for a range of effects that result from exposure to maternal alcohol consumption during gestation. Many who have this disorder have difficulty linking their actions to consequences, controlling impulses and remembering things and thus a diagnosis of FASD raises particular issues in sentencing. This article overviews the effects of FASD and the difficulties associated with its diagnosis. It then goes on to examine the appropriate aims of sentencing in FASD cases and addresses the question of whether, and if so in what circumstances, FASD should be perceived as a mitigating factor. The article concludes with a discussion of appropriate penalties for defendants who are diagnosed with FASD and makes some recommendations for increased education about the condition and increased access to resources for diagnosis and response to defendants diagnosed with FASD within the criminal justice system.
PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity

Diabetes is a multi‐organ disease and diabetic cardiomyopathy can result in heart failure, which is a leading cause of morbidity and mortality in diabetic patients. In the liver, insulin resistance contributes to hyperglycaemia and hyperlipidaemia, which further worsens the metabolic profile. Defects in mTOR signalling are believed to contribute to metabolic dysfunctions in diabetic liver and hearts, but evidence is missing that mTOR activation is causal to the development of diabetic cardiomyopathy. This study shows that specific mTORC1 inhibition by PRAS40 prevents the development of diabetic cardiomyopathy. This phenotype was associated with improved metabolic function, blunted hypertrophic growth and preserved cardiac function. In addition PRAS40 treatment improves hepatic insulin sensitivity and reduces systemic hyperglycaemia in obese mice. Thus, unlike rapamycin, mTORC1 inhibition with PRAS40 improves metabolic profile in diabetic mice. These findings may open novel avenues for therapeutic strategies using PRAS40 directed against diabetic‐related diseases.
Towards Scalable SDN Switches: Enabling Faster Flow Table Entries Installation

 Software tables are much faster to be updated than hardware ones  A hybrid architecture can exploit the following logic: • Forwarding tables updates always happen in software first • Entries are eventually moved to the hardware forwarding tables, offloading the Software forwarder  Overlapping entries may break the forwarding decisions in respect to their priorities  Deleting entries from hardware tables is usually much faster than adding them: • Installation in hardware tables may require a reorganization of the previously installed Flow Table Entries  A hybrid architecture can translate an entry installation into a mix of installation in software tables and deletion from hardware tables
Analysis of Spike Electrogenesis and Depolarizing K Inactivation in Electroplaques of Electrophorus electricus, L

Voltage clamp analyses, combined with pharmacological tools demonstrate the independence of reactive Na and K channels in electrically excitable membrane of eel electroplaques. Spike electrogenesis is due to Na activation and is eliminated by tetrodotoxin or mussel poison, or by substituting choline, K, Cs, or Rb for Na in the medium. The K channels remain reactive, but K activation is always absent, the electroplaques responding only with K inactivation. This is indicated by an increased resistance when the membrane is depolarized by more than about 30 mv. The resting resistance (1 to 5 ohm cm2) is dependent upon the ionic conditions, but when K inactivation occurs the resistance becomes about 10 ohm cm2 in all conditions. K inactivation does not change the EMF significantly. The transition from low to high resistance may give rise to a negative-slope voltage current characteristic, and to regenerative inactivation responses under current clamp. The further demonstration that pharmacological K inactivation (by Cs or Rb) leaves Na activation and spike electrogenesis unaffected emphasizes the independence of the reactive processes and suggests different chemical compositions for the membrane structures through which they operate.
Optimised phrase querying and browsing of large text databases

Most search systems for querying large document collections, e.g., Web search engines, are based on well-understood information retrieval principles. These systems are both efficient and effective in finding answers to many user information needs, expressed through informal ranked or structured Boolean queries. Phrase querying and browsing are additional techniques that can augment or replace conventional querying tools. The authors propose optimisations for phrase querying with a nextword index, an efficient structure for phrase based searching. We show that careful consideration of which search terms are evaluated in a query plan and optimisation of the order of evaluation of the plan can reduce query evaluation costs by more than a factor of five. We conclude that, for phrase querying and browsing with nextword indexes, an ordered query plan should be used for all browsing and querying. Moreover, we show that optimised phrase querying is practical on large text collections.
A robust model for simultaneously inducing corneal neovascularization and retinal gliosis in the mouse eye

Purpose To develop an animal model for simultaneously eliciting corneal angiogenesis and retinal gliosis that will enable the assessment of inhibitor efficacy on these two pathological processes in separate anatomic sites of the ocular globe. Methods Four to six week-old mice in a C57BL/6J background were anesthetized and 0.15 N NaOH was applied to the cornea, followed by mechanical scraping of the epithelium from limbus and central cornea. After this injury, mice were treated with vehicle or with an inhibitor (withaferin A [WFA]), which were delivered by intraperitoneal injection, to assess the pharmacological effects on angiogenesis and/or gliosis. Mice were sacrificed after 14 days and tissues (corneas and retinas) were prepared for analysis of corneal neovascularization and retinal gliosis by immunohistochemistry and western blotting, respectively. This protocol was also suited for studying earlier disease end points, for assessment of drug dose efficacy or genetic influences and the entire procedure and this analysis was completed in 16–17 days. Results Both corneal angiogenesis and retinal gliosis were maximally sustained at fourteen days following chemical and mechanical injury of the cornea. 1) Injured corneas showed abundant CD31+ staining, with new blood vessels branching out from the limbus to the central cornea. WFA treatment potently inhibited corneal neovascularization. 2) Retinal gliosis in injured mice was associated with upregulated expression of glial fibrillary acidic protein (GFAP) that appeared as polymeric filaments and soluble forms expressed in reactive Müller glial cells. WFA treatment potently downregulated the expression of soluble and filamentous GFAP; the latter protein was fragmented. Conclusions We have developed a mouse model for investigating retinal gliosis and corneal neovascularization. We used this model to demonstrate the simultaneous inhibitory effects of WFA on both of these disease processes. Retinal gliosis occurs in several major degenerative conditions of the eye, including age-related macular degeneration, where angiogenesis is also a prevailing pathological feature. Thus, inhibitors of both gliosis and angiogensis used as combination therapy are currently being explored for treatment of such complex diseases. The model presented here affords a very simple preclinical assay for screening combination of drugs or polypharmacological agents and reduces the numbers of animals because of the different anatomic sites of these pathologies. Finally, given that endogenous mediators elicit angiogenesis and gliosis in this model, the combination of genetics and pharmacology can be exploited to study drug mechanisms and for target validation in vivo.
AMPA receptor subunits expression and phosphorylation in cingulate cortex in rats following esophageal acid exposure

We recently reported an increase in N‐methyl‐d‐aspartate (NMDA) receptor subunit expression and CaMKII‐dependent phosphorylation of NR2B in the rostral cingulate cortical (rCC) neurons following esophageal acid exposure in rats. As α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionic acid (AMPA) receptors mediate the fast excitatory transmission and play a critical role in synaptic plasticity, in this study, we investigated the effect of esophageal acid exposure in rats on the expression of AMPA receptor subunits and the involvement of these molecular alterations in acid‐induced sensitization of neurons in the anterior cingulate (ACC) and midcingulate (MCC) cortices.
Identification and Biochemical Characterization of Small-Molecule Inhibitors of Clostridium botulinum Neurotoxin Serotype A

ABSTRACT An integrated strategy that combined in silico screening and tiered biochemical assays (enzymatic, in vitro, and ex vivo) was used to identify and characterize effective small-molecule inhibitors of Clostridium botulinum neurotoxin serotype A (BoNT/A). Virtual screening was initially performed by computationally docking compounds of the National Cancer Institute (NCI) database into the active site of BoNT/A light chain (LC). A total of 100 high-scoring compounds were evaluated in a high-performance liquid chromatography (HPLC)-based protease assay using recombinant full-length BoNT/A LC. Seven compounds that significantly inhibited the BoNT/A protease activity were selected. Database search queries of the best candidate hit [7-((4-nitro-anilino)(phenyl)methyl)-8-quinolinol (NSC 1010)] were performed to mine its nontoxic analogs. Fifty-five analogs of NSC 1010 were synthesized and examined by the HPLC-based assay. Of these, five quinolinol derivatives that potently inhibited both full-length BoNT/A LC and truncated BoNT/A LC (residues 1 to 425) were selected for further inhibition studies in neuroblastoma (N2a) cell-based and tissue-based mouse phrenic nerve hemidiaphragm assays. Consistent with enzymatic assays, in vitro and ex vivo studies revealed that these five quinolinol-based analogs effectively neutralized BoNT/A toxicity, with CB 7969312 exhibiting ex vivo protection at 0.5 μM. To date, this is the most potent BoNT/A small-molecule inhibitor that showed activity in an ex vivo assay. The reduced toxicity and high potency demonstrated by these five compounds at the biochemical, cellular, and tissue levels are distinctive among the BoNT/A small-molecule inhibitors reported thus far. This study demonstrates the utility of a multidisciplinary approach (in silico screening coupled with biochemical testing) for identifying promising small-molecule BoNT/A inhibitors.
Comparison and Adaptation of Automatic Evaluation Metrics for Quality Assessment of Re-Speaking

Re-speaking is a mechanism for obtaining high quality subtitles for use in live broadcast and other public events. Because it relies on humans performing the actual re-speaking, the task of estimating the quality of the results is non-trivial. Most organisations rely on humans to perform the actual quality assessment, but purely automatic methods have been developed for other similar problems, like Machine Translation. This paper will try to compare several of these methods: BLEU, EBLEU, NIST, METEOR, METEOR-PL, TER and RIBES. These will then be matched to the human-derived NER metric, commonly used in re-speaking.
Lentigo Maligna/Lentigo Maligna Melanoma: Current State of Diagnosis and Treatment

BACKGROUND Lentigo maligna (LM) is a subtype of melanoma in situ that typically develops on sun-damaged skin. Presentation may be quite subtle and delayed diagnosis is common. Clinical margins are often ill defined. Histologic evaluation can be difficult due to the widespread atypical melanocytes that are present in the background of long-standing sun damage. Recurrence following standard therapies is common. OBJECTIVE To review the clinical features, histopathology, and treatment options for LM. Emphasis is placed on recent advances in the treatment of LM. METHODS AND MATERIALS Literature review. RESULTS The estimated lifetime risk of LM progressing to LM melanoma is 5%. Standard excision of LM with 5 mm margins is insufficient in 50% of cases. The recurrence rate with standard excision ranges from 8 to 20%. Mohs surgery and staged excision may offer better margin control and lower recurrence rates (4–5%). Estimates of recurrence rates following nonsurgical therapies such as cryosurgery, radiotherapy, electrodessication and curettage, laser surgery, and topical medications range from 20 to 100% at 5 years. CONCLUSIONS Adequate treatment of LM requires a comprehensive knowledge of the diagnostic features, histopathology, and treatment options. Surgical modalities with meticulous evaluation of tissue margins appears to offer the lowest rates of disease recurrence.
The Self-Study and Auto-Control Model of Machine&#146;s Lifetime Learning Based on Database

The paper presents a novel design methodology for an intelligent controller based on a database capable of self-study and auto-control. The motivation stems from making a smart database analogous to human brain, namely, a dummy brain database (DBD). The data stored in the DBD may be collected from a plant/system at present, recent past and/or over a period of time in the past, i.e. the historical data. The proposed method intends to enable DBD to perform information processing, knowledge elicitation and decision making in a manner similar to human brain. In particular the features of human memory including its sensitivity, frequency of change, information update and reconstruction are researched and the mechanism of the brain's associative memories studied. The DBD thus established has led to a self-study and auto-control model which is capable for learning over the machine's lifetime. Possible applications in control of a group of elevators and in city traffic control are discussed
Book Review: Lessons from a Quechua strongwoman: Ideophony, dialogue, and perspective.

The book by Janis Nuckolls, Lessons from a Quechua strongwoman: Ideophony, dialogue, and perspective , focuses on the communicative function of ideophones which animate the native universe by giving a voice for expression to both human and non-human life-forms in the Runa dialect of Ecuadorian Pastaza Quichua (a variety of Quechua).
Query Weighting for Ranking Model Adaptation

We propose to directly measure the importance of queries in the source domain to the target domain where no rank labels of documents are available, which is referred to as query weighting. Query weighting is a key step in ranking model adaptation. As the learning object of ranking algorithms is divided by query instances, we argue that it's more reasonable to conduct importance weighting at query level than document level. We present two query weighting schemes. The first compresses the query into a query feature vector, which aggregates all document instances in the same query, and then conducts query weighting based on the query feature vector. This method can efficiently estimate query importance by compressing query data, but the potential risk is information loss resulted from the compression. The second measures the similarity between the source query and each target query, and then combines these fine-grained similarity values for its importance estimation. Adaptation experiments on LETOR3.0 data set demonstrate that query weighting significantly outperforms document instance weighting methods.
L1-norm global geometric consistency for partial-duplicate image retrieval

In all feature point based partial-duplicate image retrieval systems, false matching is a common issue. To tackle the problem, geometric contexts are widely applied to filter the inconsistent matches. This paper presents a novel method called ℓ1-norm global geometric consistency. We first form the squared distance matrices of all the matched feature points, which remain invariant under translation and rotation between partial-duplicated images. Then we find the scale difference by solving a one-variable ℓ1-norm error minimization problem, where the large sparse errors correspond to the locations of inconsistent matches. By adopting the Golden Section Search method the minimization problem can be solved efficiently. Extensive experimental results show that our method reaches higher precisions than state-of-the-art geometric verification methods in detecting inconsistent matches. Its speed is also highly competitive even when compared to local geometric consistency based methods.
Expression, inducer spectrum, domain structure, and function of MopR, the regulator of phenol degradation in Acinetobacter calcoaceticus NCIB8250

Degradation of phenol by Acinetobacter calcoaceticus NCIB8250 involves (sigma54-dependent expression of a multicomponent phenol hydroxylase and catechol 1,2-dioxygenase encoded by the mop operon. Complementation of a new mutant deficient in phenol utilization yielded the regulatory locus mopR. It is located in divergent orientation next to the mop operon. MopR is constitutively expressed at a low level from a sigma70-type promoter and belongs to the NtrC family of regulators. The amino acid sequence is similar to that of XylR regulating xylene degradation and to that of DmpR regulating dimethylphenol degradation in Pseudomonas spp. However, it shows a different effector profile for substituted phenols than DmpR. MopR activates phenol hydroxylase expression in the presence of phenol in Escherichia coli, indicating that it binds the effector. The phenol binding A domains of MopR and DmpR have fewer identical residues than the A domains of DmpR and XylR, despite the fact that XylR recognizes different effectors. This suggests that sequence conservation in the A domain does not reflect the potential to bind the respective effectors. Overexpression of the MopR A domain in the presence of wild-type MopR causes loss of mop inducibility by phenol, establishing its negative transdominance over MopR. Deletion of 110 residues from the N terminus did not affect transdominance of the truncated domain, whereas deletion of 150 residues abolished it completely. This result establishes the distinction of two subdomains, A(N) and A(C), which together constitute the A domain. The C-terminal portion of the A domain, A(C), shows considerable affinity for the C domain, even in the presence of the trigger phenol.
Location-based fast handoff for 802.11 networks

This paper presents a location-based approach that reduces handoff overhead in IEEE 802.11 networks. With this approach, a mobile station (MS) can derive the prospective access points (APs) most likely to be visited next, using the current location and the AP topology information acquired from some designated server. The server also provides parameters for AP (re)association so that the MS can re-associate with an AP directly without a probe beforehand. Further along the movement orientation, the MS can resolve a likely set of APs for preauthentication or proactive key distribution purposes. The performance evaluation indicates that our approach is promising.
On some hierarchical clustering algorithms using kernel functions

Kernel functions are remarked in the field of clustering or pattern recognition. Using the functions, good results of clustering can be obtained for data with hard nonlinear distribution. But there is the problem that the calculation cost increases using the kernel functions. In this paper, new hierarchical clustering algorithms using kernel functions are proposed. Moreover, the availability of proposed algorithms is discussed through some numerical examples. The proposed methods do not include the kernel functions positively so that the methods can be introduced into the existing resources easily.