Miracle-dz/UniFAR-FTUs huggingface dataset:
ACTIVISMO POLITICO Y REPRESENTACION DEL YO

The article investigates relationship between political activism and identity. An inquiry has been led on a sample of 200 young people (aged 18-32 years): 100 political activists and 100 young people with no social or political groups belongings. The investigated variables concern self and group representation (investigated by a set of differential semantic scales), self-esteem and Locus of Control. Then a qualitative investigation has been led on 14 activists interviewed about the meanings of their belonging. We have conducted a content analysis and a discourse analysis. The results show differences between activists and non-activists (higher selfesteem, more internal Locus of Control and different self-representation) and between left-wing and right-wing activists.
Myeloablative Treatments for Multiple Myeloma: Update of a Comparative Study of Different Regimens Used in Patients from the Spanish Registry for Transplantation in Multiple Myeloma

After a previous analysis that did not detect clear differences in the results of three conditioning regimens used for autologous stem cell transplantation (ASCT) in patients from the Spanish Registry for Transplant in Multiple Myeloma (MM), we have updated the registry, including a larger number of cases and a fourth conditioning regimen with a longer follow-up. We evaluate 472 MM patients treated with 200 mg/m 2 melphalan (MEL200), 135 patients treated with 140 mg/m 2 melphalan plus total body irradiation [(MEL140 + TBI)], 186 patients treated with 12 mg/kg busulphan plus 140 mg/m 2 melphalan (BUMEL) and 28 patients treated with 14 mg/kg busulphan followed by cyclophosphamide 120 mg/kg (BUCY). There were no significant differences in respect to either transplant related death or haematological recovery, regardless of growth factor use, between the four conditioning programs. Nevertheless, hospitalization time with MEL200 was less than with BUMEL when growth factors were used (19 ± 9 vs. 25 ± 9 days, P =0.009) and less than with MEL140 + TBI without growth factors (20 ± 8 days vs. 27 ± 9 days, P =0.002). In patients with measurable disease at ASCT (non-complete remission [CR]), BUMEL achieved a 51% CR vs. 43%-31% in the other groups (P =0.007). The response rate for patients in partial remission (PR) at ASCT was 100% with BUMEL vs. 93%-86% in the other groups (P between 0.02 and 0.0007). The median overall survival (OS) for the BUMEL group was 57 months (95% confidence interval [CI]: 51-78) as compared to 45 (CI: 36-64) months for the MEL200 group and 39 (CI: 28-72) months for the MEL140 + TBI and BUCY groups. The median event free survival (EFS) was longer in the BUMEL group [30 (CI: 22-44) mo] than in the MEL200 [22 (CI: 18-26) mo], BUCY [23 (CI: 11-50) mo] or MEL140 + TBI groups [20 (CI: 15-29) mo]. Nevertheless, the differences in OS and EFS did not reach statistical significance in either the univariate analysis or the multivariate analysis adjusted with other high prognostic weight factors. As in the initial study, differences in regards to the anti-myeloma effect of the conditioning regimens are not conclusive. However, the better response rates associated with the favorable tendency in outcome achieved with BUMEL, continue to justify further prospective studies.
Remote Computing Environment Compensating for Brain Shift

Objective: Anatomical and functional image data become invalid during an operation due to brain shift. Compensation is achieved by using intraoperative imaging to update anatomical information. To accelerate the registration and visualization of pre- and intraoperative image data, the presented work focuses on remote computing capabilities. The underlying framework efficiently combines local desktop computers and remote high-end graphics workstations exploiting expensive hardware. Methods: By performing all computations on the remote computer, the MR volumes are rigidly aligned via voxel-based registration. Using graphics hardware for acceleration, all interpolation operations are performed with 3D texture-mapping hardware. A new approach then transforms functional markers from preoperative measurements to the intraoperative situation using an automatic tracking algorithm to identify corresponding sulci. Communicating Java viewers are suggested for analyzing the results interactively on a local computer, with all calculations being performed exclusively on the remote computer. Results: The suggested approach was successfully applied in S cases using MR data containing functional markers of MEG and fMRI measurements identifying eloquent brain areas. Remote large-scale graphics hardware was thereby efficiently made available for fast registration and interactive direct volume rendering in neurosurgery. Conclusion: Overall, the presented framework demonstrates efficient access of expensive high- end hardware remotely controlled by thin clients, and further emphasizes the need to compensate for brain shift in functional neuronavigation.
An Economic Limitation to the Zone of Democratic Peace and Cooperation

The zone of democratic peace and cooperation is the premier nontrivial fact of international relations. Recent research, however, has shown that the democratic peace is substantially limited to the economically developed democracies (Mousseau, 2000). Is the zone of democratic cooperation also limited to the economically developed democracies? With the observation of most nations from 1919 to 1992, robust support is found for this hypothesis. It appears that economically developed democracies are more than eight times more likely than other states to engage each other in an intense form of interstate cooperation: collaboration in militarized conflict. Democracies with per capita incomes of less than $8,050, in contrast-77 percent of all joint democratic dyads-appear less likely than other types of states to collaborate with each other in militarized conflict. This result is consistent with the view that liberal political culture arises from economic development, and it is liberal political culture that explains the global zone of democracy, peace, prosperity, and interstate cooperation.
Stimulation of Cytolytic Activity by Interleukin‐10

Interleukin-10 (IL-10), originally identified as an inhibitor of cytokine and monokine synthesis [e.g., IL-2, interferon-γ (IFN-γ), and tumor necrosis factor (TNF-α)], modulates a wide range of immunologic activities. In the present study we have examined the induction of non-major histocompatibility complex-restricted cytolytic activity in human peripheral blood mononuclear cells (PBMCs). PBMCs incubated with human IL-10 for 3 days were used as effector cells in cytotoxicity (i.e., 51Cr release) assays against a panel of human tumor cells. In a concentration-dependent manner, IL-10 stimulated or potentiated lytic activity against several human tumor cell lines. Induction of cytolytic activities by IL-10 was neutralized by anti-IL-10 monoclonal antibodies but not by antibodies against IFN-γ or TNF-α. Co-incubation of PBMCs with IL-10 and IL-2 or IL-10 and IFN-α augmented cytolytic activity, in particular at lower effector-to-target ratios. IL-2-induced release of TNF-α was dramatically reduced by IL-10; however, the expression of lymphokineactivated killer (LAK) activity was not affected. PBMCs preactivated with IL-10 before addition of IL-2 displayed higher levels of LAK activity. Inhibition of IL-2-driven LAK activity by IL-4 is alleviated by IL-10. Finally, IL-10 is not affected by inhibitors of IL-2, such as IL-4 and transforming growth factor-β. Potential application of IL-10 to anti-tumor therapies is discussed.
Distributed Leadership in Organizations: A Review of Theory and Research

The aim of this paper is to review conceptual and empirical literature on the concept of distributed leadership (DL) in order to identify its origins, key arguments, and areas for further work. Consideration is given to the similarities and differences between DL and related concepts including ‘shared’, ‘collective’, ‘collaborative’, ‘emergent’, ‘co-‘ and ‘democratic’ leadership. Findings indicate that whilst there are some common theoretical bases, the relative usage of these concepts varies over time, between countries and between sectors. In particular, DL is a notion that has seen a rapid growth in interest since the year 2000 but research remains largely restricted to the field of school education and of proportionally more interest to UK than US-based academics. Several scholars are increasingly going to lengths to indicate that in order to be ‘distributed’ leadership need not necessarily be widely ‘shared’ or ‘democratic’ and in order to be effective there is a need to balance different ‘hybrid configurations’ of practice. The article highlights a number of areas for further attention, including three factors relating to the context of much work on DL (power and influence; organisational boundaries and context; and ethics and diversity), and three methodological and developmental challenges (ontology; research methods; and leadership development, reward and recognition). It is concluded that descriptive and normative perspectives that dominate the literature should be supplemented by more critical accounts that recognise the rhetorical and discursive significance of DL in (re)constructing leader-follower identities, mobilising collective engagement and challenging or reinforcing traditional forms of organisation.
The Yin and Yang of Memory Consolidation: Hippocampal and Neocortical

While hippocampal and cortical mechanisms of memory consolidation have long been studied, their interaction is poorly understood. We sought to investigate potential interactions with respect to trace dominance, strengthening, and interference associated with postencoding novelty or sleep. A learning procedure was scheduled in a watermaze that placed the impact of novelty and sleep in opposition. Distinct behavioural manipulations—context preexposure or interference during memory retrieval—differentially affected trace dominance and trace survival, respectively. Analysis of immediate early gene expression revealed parallel up-regulation in the hippocampus and cortex, sustained in the hippocampus in association with novelty but in the cortex in association with sleep. These findings shed light on dynamically interacting mechanisms mediating the stabilization of hippocampal and neocortical memory traces. Hippocampal memory traces followed by novelty were more dominant by default but liable to interference, whereas sleep engaged a lasting stabilization of cortical traces and consequent trace dominance after preexposure.
Geometrical approach to the conservative congruence transformation (CCT) for robotic stiffness control

In this paper, the conservative congruence transformation (CCT) for robot stiffness control is investigated by using geometrical methods. With the strategy of changing basis, it indicates that the formulation of stiffness matrix depends on the choice of coordinates. Thus, we show that the CCT can directly represent the spatial mapping relationship in robotic stiffness control. The CCT theory suggests a generalized transformation relationship in stiffness control and establishes the complete formulation of the 6/spl times/6 Cartesian stiffness matrix in the presence of external loads.
A Novel Joint Combing Time-spatial Diversity Blind Equalization Algorithm

According to the defects of constant modulus algorithm based on orthogonal wavelet transform (WT-CMA) ,and the inter-symbol Interference (ISI) caused by multi-path fading , a novel blind equalization algorithm is presented. In this proposed algorithm, FFT technique and overlapping retention algorithm are introduced firstly to realize WT-CMA in frequency domain (FWTCMA), which obtains a better performance and little computational complexity contrast with WT-CMA. Secondly, a new time-spatial structure is proposed which exploit the advantages of time diversity and spatial diversity with different combining modes to overcome the multi-path fading and the problem caused by the single mode effectively. Then, the presented structure is applied to the FWTCMA to get a novel joint combining time-spatial diversity blind equalization algorithm (JCTSD-FWTCMA). The simulation results show that the proposed algorithm has low Mean Square Error (MSE) and computational complexity, fast convergence rate.
Anti-Apoptotic Effect of Magnolol in Myocardial Ischemia and Reperfusion Injury Requires Extracellular Signal-Regulated Kinase1/2 Pathways in Rat In Vivo

Magnolol, an active component extracted from Magnolia officinalis, has been reported to have protective effect on ischemia and reperfusion (I/R)-induced injury in experimental animals. The aim of the present investigation was to further evaluate the mechanism(s) by which magnolol reduces I/R-induced myocardial injury in rats in vivo. Under anesthesia, left anterior descending (LAD) coronary artery was occluded for 30 min followed by reperfusion for 24 h (for infarct size and cardiac function analysis). In some experiments, reperfusion was limited to 1 h or 6 h for analysis of biochemical and molecular events. Magnolol and DMSO solution (vehicle) were injected intra-peritoneally 1 h prior to I/R insult. The infarct size was measured by TTC technique and heart function was monitored by Millar Catheter. Apoptosis related events such as p-ERK, p-Bad, Bcl-xl and cytochrome c expression were evaluated by Western blot analysis and myocardial caspase-3 activity was also measured. Magnolol (10 mg/kg) reduced infarct size by 50% (P < 0.01 versus vehicle), and also improved I/R-induced myocardial dysfunction. Left ventricular systolic pressure and positive and negative maximal values of the first derivative of left ventricular pressure (dP/dt) were significantly improved in magnolol-treated rats. Magnolol increased the expression of phosphor ERK and Bad which resulted in inhibition of myocardial apoptosis as evidenced by TUNEL analysis and DNA laddering experiments. Application of PD 98059, a selective MEK1/2 inhibitor, strongly antagonized the effect of magnolol. Taken together, we concluded that magnolol inhibits apoptosis through enhancing the activation of ERK1/2 and modulation of the Bcl-xl proteins which brings about reduction of infarct size and improvement of cardiac function in I/R-induced injury.
Regulation of carotenoid accumulation and the expression of carotenoid metabolic genes in citrus juice sacs in vitro

In the present study, to investigate the mechanisms regulating carotenoid accumulation in citrus, a culture system was set up in vitro with juice sacs of three citrus varieties, Satsuma mandarin (Citrus unshiu Marc.), Valencia orange (Citrus sinensis Osbeck), and Lisbon lemon (Citrus limon Burm.f.). The juice sacs of all the three varieties enlarged gradually with carotenoid accumulation. The changing patterns of carotenoid content and the expression of carotenoid metabolic genes in juice sacs in vitro were similar to those ripening on trees in the three varieties. Using this system, the changes in the carotenoid content and the expression of carotenoid metabolic genes in response to environmental stimuli were investigated. The results showed that carotenoid accumulation was induced by blue light treatment, but was not affected by red light treatment in the three varieties. Different regulation of CitPSY expression, which was up-regulated by blue light while unaffected by red light, led to different changes in carotenoid content in response to these two treatments in Satsuma mandarin and Valencia orange. In all three varieties, increases in carotenoid content were observed with sucrose and mannitol treatments. However, the accumulation of carotenoid in the two treatments was regulated by distinct mechanisms at the transcriptional level. With abscisic acid (ABA) treatment, the expression of the genes investigated in this study was up-regulated in Satsuma mandarin and Lisbon lemon, indicating that ABA induced its own biosynthesis at the transcriptional level. This feedback regulation of ABA led to decreases in carotenoid content. With gibberellin (GA) treatment, carotenoid content was significantly decreased in the three varieties. Changes in the expression of genes related to carotenoid metabolism varied among the three varieties in response to GA treatment. These results provided insights into improving carotenoid content and composition in citrus during fruit maturation.
Cloning and Characterization of ATRAP, a Novel Protein That Interacts with the Angiotensin II Type 1 Receptor*

The carboxyl-terminal cytoplasmic domain of the angiotensin II type 1 (AT1) receptor has recently been shown to interact with several classes of cytoplasmic proteins that regulate different aspects of AT1 receptor physiology. Employing yeast two-hybrid screening of a mouse kidney cDNA library with the carboxyl-terminal cytoplasmic domain of the murine AT1a receptor as a bait, we have isolated a novel protein with a predicted molecular mass of 18 kDa, which we have named ATRAP (for AT1 receptor-associated protein). ATRAP interacts specifically with the carboxyl-terminal domain of the AT1areceptor but not with those of angiotensin II type 2 (AT2), m3 muscarinic acetylcholine, bradykinin B2, endothelin B, and β2-adrenergic receptors. The mRNA of ATRAP was abundantly expressed in kidney, heart, and testis but was poorly expressed in lung, liver, spleen, and brain. The ATRAP-AT1a receptor association was confirmed by affinity chromatography, by specific co-immunoprecipitation of the two proteins, and by fluorescence microscopy, showing co-localization of these proteins in intact cells. Overexpression of ATRAP in COS-7 cells caused a marked inhibition of AT1a receptor-mediated activation of phospholipase C without affecting m3 receptor-mediated activation. In conclusion, we have isolated a novel protein that interacts specifically with the carboxyl-terminal cytoplasmic domain of the AT1a receptor and affects AT1a receptor signaling.
Mining the Web for Sympathy: The Pussy Riot Case

With social media services becoming more and more popular, there now exists a constant stream of opinions publicly available on the Internet. In crisis situations, analysis of social media data can improve situation awareness and help authorities to provide better assistance to the affected population. The large amount of activity on social media services makes manual analysis infeasible. Thus, an automatic system that can assess the situation is desirable. In this paper we present the results of training machine learning classifiers to being able to label tweets with one of the sentiment labels positive, neutral, and negative. The classifiers were evaluated on a set of Russian tweets that were collected immediately after the much debated verdict in the 2012 trial against members of the Russian punk rock collective Pussy Riot. The aim for the classification process was to label the tweets in the dataset according to the author's sentiment towards the defendants in the trial. The results show that the obtained classifiers do not accurately and reliably classify individual tweets with sufficient certainty. However, the classifiers do show promising results on an aggregate level, performing significantly better than a majority class baseline classifier would.
The relationship between patients' perception of the effects of neurofibromatosis type 2 and the domains of the Short Form-36.

OBJECTIVES To investigate the relationship between those issues concerning quality of life in patients with neurofibromatosis type 2 (NF2) as identified by the closed set NF2 questionnaire and the eight norm-based measures and the physical component summary (PCS) and mental component summary (MCS) scores of the Short Form-36 (SF-36) Questionnaire. DESIGN Postal questionnaire study. SETTING Questionnaires sent to subjects' home addresses. PARTICIPANTS Eighty-seven adult subjects under the care of the Manchester Multidisciplinary NF2 Clinic were invited to participate. MAIN OUTCOME MEASURES Sixty-two (71%) completed sets of closed set NF2 questionnaires and SF-36 questionnaires were returned. RESULTS Subjects with NF2 scored less than the norm of 50 on both the physical component summary and mental component summary scores and the eight individual norm-based measures of the Short Form-36 questionnaire. Correlations (using Kendall's tau) were examined between patients' perceptions of their severity of difficulty with the following activities and the eight norm-based measures and the physical component summary and mental component summary scores of the Short Form-36 questionnaire: Communicating with spouse/significant other (N = 61). The correlation coefficients were significant at the 0.01 level for the mental component summary score, together with three of the norm-based scores [vitality (VT), social functioning and role emotional]. Social communication (N = 62). All 10 correlations were significant at the 0.01 or 0.001 level. Balance (N = 59). All 10 correlations were highly significant at the P < 0.001 level. Hearing difficulties (N = 61). All correlations were significant at either the 0.01 level or less apart from the mental component summary score and three of the norm-based scores (role physical, VT and mental health). Mood change (N = 61). All correlations were significant at the 0.01 level or less, apart from one norm-based score (role physical). CONCLUSIONS The Short Form-36 questionnaire has allowed us to relate patients' perceptions of their difficulties, as identified by the closed set NF2 questionnaire, to the physical and mental domains measured by this validated and widely used scale, and has provided further insight into areas of functioning affected by NF2.
Lipid IVA inhibits synthesis and release of tumor necrosis factor induced by lipopolysaccharide in human whole blood ex vivo

Tumor necrosis factor (TNF) released by lipopolysaccharide (LPS)- stimulated mononuclear phagocytes is a critical mediator of sepsis. We examined the capacities of rough mutant Salmonella typhimurium LPS (Rc) and LPS partial structures lipid A, monophosphoryl lipid A (MPLA), lipid IVA, and lipid X to induce production of TNF in whole blood. Rc LPS (0.0001-10 ng/ml) produced a dose-dependent release of TNF as determined by cytotoxicity of actinomycin D-sensitized L929 murine fibroblasts. Lipid A, MPLA, lipid IVA, and lipid X exhibited decreasing capacities to stimulate production of TNF in whole blood, respectively. Fractional deacylation of LPS by incubation with acyloxyacyl hydrolase isolated from human leukocytes produced a reduction in the capacity of LPS to induce TNF release in whole blood. Maximal enzymatic deacylation reduced activity of LPS by greater than 100-fold. Coincubation with lipid IVA inhibited TNF release induced by Rc LPS or lipid A, but not by phorbol ester. In contrast, MPLA, lipid X, and deacylated LPS failed to inhibit LPS-stimulated release of TNF. Corresponding to the inhibition of the release of TNF protein, lipid IVA also inhibited the accumulation of TNF mRNA in LPS-stimulated mononuclear cells. These results suggest that lipid IVA may act as a competitive antagonist of LPS, perhaps at the receptor level.