Miracle-dz/UniFAR-FTUs huggingface dataset:
POWERDRESS and HDA9 interact and promote histone H3 deacetylation at specific genomic sites in Arabidopsis

Significance Histone deacetylases (HDACs) belong to a large protein family in plants, and little is known about how target specificity of each HDAC is achieved. We show that a paired SANT (SWI3/DAD2/N-CoR/TFIII-B) domain-containing protein, POWERDRESS, specifically acts with HDA9 to confer the deacetylation of histone H3 lysine residues at a set of genomic targets to regulate various biological processes. Our study elucidates the functional correlation between SANT domain-containing proteins and HDACs in plants. Histone acetylation is a major epigenetic control mechanism that is tightly linked to the promotion of gene expression. Histone acetylation levels are balanced through the opposing activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs). Arabidopsis HDAC genes (AtHDACs) compose a large gene family, and distinct phenotypes among AtHDAC mutants reflect the functional specificity of individual AtHDACs. However, the mechanisms underlying this functional diversity are largely unknown. Here, we show that POWERDRESS (PWR), a SANT (SWI3/DAD2/N-CoR/TFIII-B) domain protein, interacts with HDA9 and promotes histone H3 deacetylation, possibly by facilitating HDA9 function at target regions. The developmental phenotypes of pwr and hda9 mutants were highly similar. Three lysine residues (K9, K14, and K27) of H3 retained hyperacetylation status in both pwr and hda9 mutants. Genome-wide H3K9 and H3K14 acetylation profiling revealed elevated acetylation at largely overlapping sets of target genes in the two mutants. Highly similar gene-expression profiles in the two mutants correlated with the histone H3 acetylation status in the pwr and hda9 mutants. In addition, PWR and HDA9 modulated flowering time by repressing AGAMOUS-LIKE 19 expression through histone H3 deacetylation in the same genetic pathway. Finally, PWR was shown to physically interact with HDA9, and its SANT2 domain, which is homologous to that of subunits in animal HDAC complexes, showed specific binding affinity to acetylated histone H3. We therefore propose that PWR acts as a subunit in a complex with HDA9 to result in lysine deacetylation of histone H3 at specific genomic targets.
Sphere-trees generation as needed in real time

In this paper two improvements to speed up collision detection are described. Firstly, a method called oncollide sphere-tree, OCST for short, is presented. This approach works by detecting collisions among models with arbitrary geometry using the video card’s Graphics Processing Units, GPU. While candidate parts of colliding objects are being detected, the OCST is constructed for collision evaluation in parallel, at the same time. Thus, the OCST is created in real–time. Secondly, we have tested two kinds of triangulated representation models for the same original–objects. We have evaluated triangle–soup and triangle–strip models to speed up the algorithm response when computing collisions. The method has been described, implemented and tested for the two kinds of triangulated models, and the obtained results are shown.
A 2.56 Gb/s Soft RS (255, 239) Decoder Chip for Optical Communication Systems

Due to high transmission rate requirement for optical communication systems, the growing uncertainty of received signals results in the limited transmission distance. In this paper, a decision-confined soft RS decoder chip is proposed to enhance the error correcting performance with area-efficient architectures. Instead of generating numerous possible candidate codewords and determining the most likely one as output codeword, our approach produces only one codeword by confining the degree of error location polynomial. Therefore, hardware complexity is significantly reduced by eliminating decision making unit. Moreover, an iteration-reduced RiBM algorithm is provided to enlarge the coding gain by using more least reliable positions (LRPs) in the limited operation latency. According to simulation results, our proposed soft RS (255, 239; 8) decoder with 5 LRPs outperforms 0.4 dB at 10 -4 codeword error rate (CER) as compared to hard RS decoders. Implemented in standard CMOS 90 nm technology, the soft decoder chip can achieve 2.56 Gb/s throughput with similar complexity as a hard decoder. It can fit well for 10-40 Gb/s with 16 RS decoders in optical fiber systems and 2.5 Gb/s GPON applications.
A new non-uniform loop scheme

In this paper, we introduce a new non-uniform Loop scheme. It refines selected areas which are chosen manually or automatically according to the precision of the control mesh compared to the limit surface. Our algorithm avoids cracks and generates a progressive mesh with a difference of at most one subdivision level between two adjacent faces. As adaptive subdivision is repeated, subdivision depth changes gradually from one area of the surface to another area. Moreover generated meshes remain a regular valence. Results obtained from our scheme are compared to those of the T-algorithm and the incremental algorithm.
The digital hood: Social media use among youth in disadvantaged neighborhoods

This study examines the role of social media in the lives of youth living in disadvantaged neighborhoods. Feminist Standpoint Theory, which privileges the voices of marginalized communities in understanding social phenomena, suggests that youth at the margins have specific knowledge that helps us understand social media more broadly. We conducted semi-structured interviews with 30 females and 30 males aged 13–24 years about their social worlds and neighborhoods, both online and offline. The findings reveal a dynamic and somewhat concerning interplay between the geographic neighborhood and the digital neighborhood, whereby negative social interactions in the geographic neighborhood are reproduced and amplified on social media.
Short-term wind power prediction based on wavelet transform-support vector machine and statistic characteristics analysis

The prediction algorithm is an important key factor in wind power prediction. However, there are pros and cons on different forecasting algorithms. Based on the principles of wavelet transform (WT), support vector machine (SVM) as well as characteristics of wind turbine generation systems, two prediction methods are presented and compared in this paper. In method 1, the time series of model input are decomposed into different frequency composes and models are set up separately based on SVM. The results are combined together to obtain the final wind power output. In method 2, the wavelet kernel function is applied in place of RBF kernel function in SVM training. To supply more valuable suggestions, the means of evaluating prediction algorithm precision is proposed. The operation data from two wind farms both in North China and U.S.A are used to test the usability of the method. The mean relative error of WT-SVM model (method 1) is less than that of traditional SVM model.
Immunoproteasomes Largely Replace Constitutive Proteasomes During an Antiviral and Antibacterial Immune Response in the Liver1

The proteasome is critically involved in the production of MHC class I-restricted T cell epitopes. Proteasome activity and epitope production are altered by IFN-γ treatment, which leads to a gradual replacement of constitutive proteasomes by immunoproteasomes in vitro. However, a quantitative analysis of changes in the steady state subunit composition of proteasomes during an immune response against viruses or bacteria in vivo has not been reported. Here we show that the infection of mice with lymphocytic choriomeningitis virus or Listeria monocytogenes leads to an almost complete replacement of constitutive proteasomes by immunoproteasomes in the liver within 7 days. Proteasome replacements were markedly reduced in IFN-γ−/− mice, but were only slightly affected in IFN-αR−/− and perforin−/− mice. The proteasome regulator PA28α/β was up-regulated, whereas PA28γ was reduced in the liver of lymphocytic choriomeningitis virus-infected mice. Proteasome replacements in the liver strongly altered proteasome activity and were unexpected to this extent, since an in vivo half-life of 12 days had been previously assigned to constitutive proteasomes in the liver. Our results suggest that during the peak phase of viral and bacterial elimination the antiviral cytotoxic T lymphocyte response is directed mainly to immunoproteasome-dependent T cell epitopes, which would be a novel parameter for the design of vaccines.
Molecular Identification and Partial Characterization of Pediococcus sp . and Leuconostoc sp . Isolated from Traditionally Made Dairy Products

Lactic acid bacteria (LAB) are group of commercially important organisms that play an important role in the fermentation process of hexose sugars into lactic acid and they are videly used in dairy industrial applications since they were designated as “generally recognised as safe” organisms. In order to isolate laktic acid bacteria (LAB), forty fermented food samples were collected and 160 bacterial strains were purified and identified from those samples. According to morphological characteristics, 62 isolates (38.75%) were classified as cocci and all these cocci were found to be as catalase negative and grown well on MRS agar plates. Coccobacilli and bacilli forms were observed in 66 (41.25%) and 19 (11.875%) isolates respectively. Total of 13 isolates (8.125%) were classified as “others” (according to morphological characteristics) and excluded from rest of experimental process. For molecular identification of Leuconostoc sp. and Pediococcus sp. , 16S and 23S rDNAs (respectively) were amplified with the aid of PCR and 34 of them were classified as Pediococcus whilst 4 of them were designated as Leuconostoc. These newly isolated strains were tested for their antimicrobial activity and more than one strains exhibited antimicrobial activity against to S. paratyphi and E. faecali. All tested strains showed relatively lower (≤ 10mm in diameter) antimicrobial effect against P. mirabilis, E. coli and C. jejuni while P. aeruginosa showed resistancy against all bacteriocins produced tested isolates. Result of this study revealed that majority of the tested (n=20) isolates were resistant to erythromycin, chloramphenicol and rifampin. All isolates were investigated for the presence of plasmid vectors and 10 of them found having at least 1 plasmid vector. DOI : 10.18016/ksudobil.298876 Article History Received : 20.03. 2017 Accepted : 12.04. 2017
Excess mortality in persons with severe mental disorders: a multilevel intervention framework and priorities for clinical practice, policy and research agendas

Excess mortality in persons with severe mental disorders (SMD) is a major public health challenge that warrants action. The number and scope of truly tested interventions in this area remain limited, and strategies for implementation and scaling up of programmes with a strong evidence base are scarce. Furthermore, the majority of available interventions focus on a single or an otherwise limited number of risk factors. Here we present a multilevel model highlighting risk factors for excess mortality in persons with SMD at the individual, health system and socio‐environmental levels. Informed by that model, we describe a comprehensive framework that may be useful for designing, implementing and evaluating interventions and programmes to reduce excess mortality in persons with SMD. This framework includes individual‐focused, health system‐focused, and community level and policy‐focused interventions. Incorporating lessons learned from the multilevel model of risk and the comprehensive intervention framework, we identify priorities for clinical practice, policy and research agendas.
PR ] 1 1 M ar 2 01 3 Coarsening in 2 D slabs

We study coarsening; that is, the zero-temperature limit of Glauber dynamics in the standard Ising model on slabs Sk = Z ×{0, . , k−1} of all thicknesses k ≥ 2 (with free and periodic boundary conditions in the third coordinate). We show that with free boundary conditions, for k ≥ 3, some sites fixate for large times and some do not, whereas for k = 2, all sites fixate. With periodic boundary conditions, for k ≥ 4, some sites fixate and others do not, while for k = 2 and 3, all sites fixate.
Reviewing the Governance Structure of End-User Support in e-Science Infrastructures

The research into e-Science infrastructures has changed the face of traditional scientific methods. The maturity of grid technology to get the data distributed around the globe has raised possibilities to perform ground-breaking research within a specific scientific community. However, the governance and management of user support services of e-Science infrastructures yet remain an under-studied topics. Currently, there is hardly a study undertaken to see what governance approach may be suitable to enrich the user support services that an eScience infrastructure may provide. In this paper, the governance context of the user support services of a use case of a climate e-Science infrastructures: Earth System Grid Federation (ESGF) is taken as a case study. Amongst the plethora of challenges that the user support process in ESGF face, we focus on its governance and make recommendations to improve it. The recommendations are based on an empirical study conducted to find out the current state of user support governance.
Pre-referral Rectal Artesunate Treatment by Community-Based Treatment Providers in Ghana, Guinea-Bissau, Tanzania, and Uganda (Study 18): A Cluster-Randomized Trial

Background. If malaria patients who cannot be treated orally are several hours from facilities for injections, rectal artesunate prior to hospital referral can prevent death and disability. The goal is to reduce death from malaria by having rectal artesunate treatment available and used. How best to do this remains unknown. Methods. Villages remote from a health facility were randomized to different community-based treatment providers trained to provide rectal artesunate in Ghana, Guinea-Bissau, Tanzania, and Uganda. Prereferral rectal artesunate treatment was provided in 272 villages: 109 through community-based health workers (CHWs), 112 via trained mothers (MUMs), 25 via trained traditional healers (THs), and 26 through trained community-chosen personnel (COMs); episodes eligible for rectal artesunate were established through regular household surveys of febrile illnesses recording symptoms eligible for prereferral treatment. Differences in treatment coverage with rectal artesunate in children aged <5 years in MUM vs CHW (standard-of-care) villages were assessed using the odds ratio (OR); the predictive probability of treatment was derived from a logistic regression analysis, adjusting for heterogeneity between clusters (villages) using random effects. Results. Over 19 months, 54 013 children had 102 504 febrile episodes, of which 32% (31 817 episodes) had symptoms eligible for prereferral therapy; 14% (4460) children received treatment. Episodes with altered consciousness, coma, or convulsions constituted 36.6% of all episodes in treated children. The overall OR of treatment between MUM vs CHW villages, adjusting for country, was 1.84 (95% confidence interval [CI], 1.20–2.83; P = .005). Adjusting for heterogeneity, this translated into a 1.67 higher average probability of a child being treated in MUM vs CHW villages. Referral compliance was 81% and significantly higher with CHWs vs MUMs: 87% vs 82% (risk ratio [RR], 1.1 [95% CI, 1.0–1.1]; P < .0001). There were more deaths in the TH cluster than elsewhere (RR, 2.7 [95% CI, 1.4–5.6]; P = .0040). Conclusions. Prereferral episodes were almost one-third of all febrile episodes. More than one-third of patients treated had convulsions, altered consciousness, or coma. Mothers were effective in treating patients, and achieved higher coverage than other providers. Treatment access was low. Clinical Trials Registration. ISRCTN58046240.
Pharmacologic targeting of endothelial Ca2+-activated K+ channels: A strategy to improve cardiovascular function

ABSTRACT Endothelial small and intermediate-conductance, Ca2+-activated K+ channels (KCa2.3 and KCa3.1, respectively) play an important role in the regulation of vascular function and systemic blood pressure. Growing evidence indicates that they are intimately involved in agonist-evoked vasodilation of small resistance arteries throughout the circulation. Small molecule activators of KCa2.x and 3.1 channels, such as SKA-31, can acutely inhibit myogenic tone in isolated resistance arteries, induce effective vasodilation in intact vascular beds, such as the coronary circulation, and acutely decrease systemic blood pressure in vivo. The blood pressure-lowering effect of SKA-31, and early indications of improvement in endothelial dysfunction suggest that endothelial KCa channel activators could eventually be developed into a new class of endothelial targeted agents to combat hypertension or atherosclerosis. This review summarises recent insights into the activation of endothelial Ca2+ activated K+ channels in various vascular beds, and how tools, such as SKA-31, may be beneficial in disease-related conditions.
An Image Processing Algorithm Based on Multiple Wavelet

To extract foreground area is a shallow depth of field image smoothing depth of the problem of the great error, to modify the depth value based on pixel classification, put forward a kind of based on multi-scale wavelet clues, but at the same time for arrangement of the depth of the shallow depth of field image and wide-angle image extraction algorithm. The first to use wavelet analysis to extract the image depth information in multiple scales; and then put forward an adaptive classification and according to the scale and depth change rule of pixel depth correction, get depth map; finally combining region growing and edge segmentation algorithm on depth map area optimization. In order to speed up the depth calculation, also put forward the rapid zero-count method and multi-scale method to meet the standard definition video real-time processing requirement. The experimental results show that the proposed algorithm to obtain the depth of the figure relative depth right, foreground and background area depth good consistency.
Effects of endurance training on hsa-miR-223, P2RY12 receptor expression and platelet function in type 2 diabetic patients.

BACKGROUND Type 2 diabetes mellitus (T2DM) is associated with thrombotic events due to platelets' defects. OBJECTIVE The aim of this study was to investigate the effects of endurance training on expressions of platelet hsa-miR-223 and P2RY12 receptor, as well as platelet function in T2DM patients. METHODS Twenty female T2DM patients (age, 62.25±3.81 yr; weight, 73.53±9.04 kg; height, 154.7±4.3 cm) were randomly divided into two groups (Control (CONT) and endurance training (ET)). Subjects in ET group performed eight weeks of running on treadmill at 60-75% of VO2peak (moderate intensity), 3 sessions per week, while, the subjects in control group were not involved in any kind of exercise training. Two blood samples were taken before and 48 h after the training and were analyzed for platelet aggregation, and hsa-miR-223 and P2RY12 expressions. RESULTS Although platelet aggregation decreased significantly in ET group (P < 0.05), these changes were not significantly different between two groups. Expression of platelet hsa-miR-223 increased and P2RY12 mRNA reduced following ET non-significantly. However, decreases in fasting blood glucose, glycated hemoglobin and body weight, and increases in VO2peak following ET were significantly different when compared to control group (P < 0.05). CONCLUSIONS Short-term endurance training dose not induce up-regulation of hsa-miR-223 and down-regulation of P2RY12, while it has a positive impact on platelet function, glycemic indices, physical fitness and body composition in female T2DM patients.
Clinical Impact and Cost-effectiveness of Diagnosing HIV Infection During Early Infancy in South Africa: Test Timing and Frequency.

BACKGROUND Diagnosis of human immunodeficiency virus (HIV) infection during early infancy (commonly known as "early infant HIV diagnosis" [EID]) followed by prompt initiation of antiretroviral therapy dramatically reduces mortality. EID testing is recommended at 6 weeks of age, but many infant infections are missed. DESIGN/METHODS We simulated 4 EID testing strategies for HIV-exposed infants in South Africa: no EID (diagnosis only after illness; hereafter, "no EID"), testing once (at birth alone or at 6 weeks of age alone; hereafter, "birth alone" and "6 weeks alone," respectively), and testing twice (at birth and 6 weeks of age; hereafter "birth and 6 weeks"). We calculated incremental cost-effectiveness ratios (ICERs), using discounted costs and life expectancies for all HIV-exposed (infected and uninfected) infants. RESULTS In the base case (guideline-concordant care), the no EID strategy produced a life expectancy of 21.1 years (in the HIV-infected group) and 61.1 years (in the HIV-exposed group); lifetime cost averaged $1430/HIV-exposed infant. The birth and 6 weeks strategy maximized life expectancy (26.5 years in the HIV-infected group and 61.4 years in the HIV-exposed group), costing $1840/infant tested. The ICER of the 6 weeks alone strategy versus the no EID strategy was $1250/year of life saved (19% of South Africa's per capita gross domestic product); the ICER for the birth and 6 weeks strategy versus the 6 weeks alone strategy was $2900/year of life saved (45% of South Africa's per capita gross domestic product). Increasing the proportion of caregivers who receive test results and the linkage of HIV-positive infants to antiretroviral therapy with the 6 weeks alone strategy improved survival more than adding a second test. CONCLUSIONS EID at birth and 6 weeks improves outcomes and is cost-effective, compared with EID at 6 weeks alone. If scale-up costs are comparable, programs should add birth testing after strengthening 6-week testing programs.
The Influence of Debate on Chinese College Studentsr Critical Thinking Disposition: A Multiple Case Study Based on Paul-Elder Model of Critical Thinking

In China, compared with the growing enthusiasm in debate among Chinese students, research in this field is relatively weak. Therefore, in order to gain an in-depth understanding of how forensic participation influence students’ critical thinking, especially their intellectual disposition, I conducted this multiple case study based on Paul-Elder Model of Critical Thinking. My research question is “How does Chinese college students’ critical thinking disposition change as a result of participating in debate? ” After six month’s observation on the debate team and three face-to-face interviews with each respondent, I found that forensic participation helps developing student’s intellectual traits, which are indispensable to critical thinking skills. Moreover, forensic participation helps the students to get rid of ego-centric and socio-centric thinking, which paves the way for them to become real critical thinkers. Keywords—Debate; Intellectual traits; Paul-Elder Model of Critical Thinking; Multiple case study