Miracle-dz/UniFAR-FTUs huggingface dataset:
lncrna expression and implication in osteosarcoma: a systematic review and meta-analysis

Purpose: Osteosarcoma is the most prevalent primary bone tumor in children, adolescents, and older adults, typically presenting with poor survival outcomes. In recent years, ample evidence has shown that many long noncoding RNAs (lncRNAs) have been aberrantly expressed in osteosarcoma, demonstrating their potential to serve as prognostic markers. In this study, we performed a meta-analysis on four lncRNAs (TUG1, UCA1, BCAR4, and HULC) to systematically evaluate their prognostic value in osteosarcoma. Materials and methods: The eligible articles were systematically searched in PubMed, Web of Science, Embase, and Elsevier ScienceDirect (up to September 22, 2017), and one meta-analysis concerning the association between lncRNA expression and the overall survival (OS) of osteosarcoma patients was performed. Survival outcomes were analyzed by OS. Subgroup analyses were performed. Results: A total of 1,361 patients with osteosarcoma and 12 lncRNAs from 16 articles were included in the study. Of the listed lncRNAs, the high expression of 10 lncRNAs indicated worse survival outcomes, while only two lncRNAs were shown to positively affect patients’ OS. Conclusion: This meta-analysis indicated that the abnormally expressed lncRNAs might significantly affect the survival of osteosarcoma patients. Combined use of these lncRNAs may serve as potential novel biomarkers for the indication of clinical outcomes of osteosarcoma patients as well as the selection of adjuvant chemotherapy strategies for clinical treatment of this disease.
PENINGKATAN MOTIVASI DAN HASIL BELAJAR MAHASISWA MELALUI PENERAPAN STRATEGI PEMBELAJARAN INKUIRI

The aim of the research was to know the effect of the implementation of an inquiry learning strategy in increasing students’ learning motivation and achivement. The research is classified into a classroom action research. The research was conducted in the teaching of Program Evaluation subject at Educational Technology Study Program. The subject of the research was the seventh semester students. The research was conducted in three circles. Each circle consisted of four steps: planning, implementation, observation, and reflection. The data were collected through observation, questionnaire, and test. The data were analyzed descriptively and statistically. The findings of the research showed that the use of inquiry learning strategy increased students’ learning motivation in the teaching of Evaluation Program subject. The increase of students’ motivation was observed individually and classically. With high learning motivation, in the long run, it is predicted that students’ learning achievement would also increase.
Comparative analysis of intragroup intermale relationships: A study of wild bonobos (Pan paniscus) in Wamba, Democratic Republic of Congo and chimpanzees (Pan troglodytes) in Kalinzu Forest Reserve, Uganda

Although chimpanzees (Pan troglodytes) and bonobos (Pan paniscus) share a multi-male/multi-female societal organization and form male-philopatric groups, disparities in terms of male aggression and stability of temporary parties exist among them. However, existing research has mainly focused on the high social status, prolonged receptivity, and characteristic sexual behaviors of female bonobos, leaving the behaviors of male bonobos understudied. Moreover, prior comparative studies suffer from methodological inconsistencies. This study addresses these gaps by employing a uniform observation method to explore party attendance and aggressive interactions among male bonobos in Wamba and male chimpanzees in Kalinzu. Unlike male chimpanzees that exhibit dispersion in the absence of receptive females in the group, male bonobos showed a lesser degree of such dispersion. Although the overall frequency of aggressive interactions per observation unit did not significantly differ between the two species, the nature of these interactions varied. Notably, severe aggressive behaviors such as physical confrontations among adult males were absent in bonobos, with most aggression occurring between the sons of the two highest-ranking females. Additionally, in bonobos, females actively engaged in polyadic aggressive behavior as aggressors, while all instances of coalitionary aggression in chimpanzees originated from male aggressors. These findings underscore the substantial impact of female behaviors on the observed distinctions in male aggressive interactions between the two species.
Examining Women ’ s Perceptions of Maternity Care in the public and private sectors of National Guard Hospitals in Saudi Arabia : A Qualitative Study

Patient satisfaction is considered one proxy for quality of care provided by both doctors and hospitals (Prakash, 2010). Due to multiple components that encompass satisfaction (i.e. care experience, patient engagement, perceptions, and preferences), defining and assessing it can be associated with numerous challenges (13). One definition of patient satisfaction is “a measure of the extent to which a patient is content with the health care which they received from their health care provider” (Farley, 2014). There are three major determinants of satisfaction: patient’s expectation, patient’s characteristics, and patients’ psychological determination (Sitzia & Wood, 1997). Donabedian believes in integrating patients in the care experience and measuring their satisfaction can contribute to quality assurance in a significant way (Donabedian, 1992).
Did Dōgen Go to China?: What He Wrote and When He Wrote It

D=ogen (1200-1253), the founder of the S=ot=o Zen sect in Japan, is especially known for introducing to Japanese Buddhism many of the texts and practices that he discovered in China. Heine reconstructs the context of D=ogen's travels to and reflections on China by means of a critical look at traditional sources both by and about D=ogen in light of recent Japanese scholarship. While many studies emphasize the unique features of D=ogen's Japanese influences, this book calls attention to the way Chinese and Japanese elements were fused in D=ogen's religious vision. It reveals many new materials and insights into Dogen's main writings, including the multiple editions of the Sh=ob=ogenz=o, and how and when this seminal text was created by D=ogen and was edited and interpreted by his disciples. This book is the culmination of the author's thirty years of research on D=ogen and provides the reader with a comprehensive approach to the master's life works and an understanding of the overall career trajectory of one of the most important figures in the history of Buddhism and Asian religious thought.
Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy

While cell fate determination and maintenance are important in establishing and preserving tissue identity and function during development, aberrant cell fate transition leads to cancer cell heterogeneity and resistance to treatment. Here, we report an unexpected role for the transcription factor p63 (Trp63/TP63) in the fate choice of squamous versus neuroendocrine lineage in esophageal development and malignancy. Deletion of p63 results in extensive neuroendocrine differentiation in the developing mouse esophagus and esophageal progenitors derived from human embryonic stem cells. In human esophageal neuroendocrine carcinoma (eNEC) cells, p63 is transcriptionally silenced by EZH2-mediated H3K27 trimethylation (H3K27me3). Upregulation of the major p63 isoform ΔNp63α, through either ectopic expression or EZH2 inhibition, promotes squamous transdifferentiation of eNEC cells. Together these findings uncover p63 as a rheostat in coordinating the transition between squamous and neuroendocrine cell fates during esophageal development and tumor progression.
Validation Test Report for the NRL Ocean Surface Flux (NFLUX) Quality Control and 2D Variational Analysis System

Abstract : The Naval Research Laboratory (NRL) Ocean Surface Flux System Version 1 (NFLUX) provides observation processing, quality control, and analysis of measurements of ocean surface state variables for application with ocean models. The three gridded analysis fields produced by the NFLUX system are 5-meter air temperature, 5-meter specific humidity, and 10-meter wind speed. The NFLUX system consists of three components: processing satellite retrievals of ocean surface state variables (NFLUX PRE), automated quality control of the observations (NFLUX QC), and 2D variational analyses of the satellite and in situ data with atmospheric models (NFLUX VAR). This document reviews and presents the current capability of the second and third components of the NFLUX system. NFLUX produces 6-hourly global and regional analysis fields, which are compared to current operational ocean forcing models (i.e., NOGAPS and COAMPS), and validated against 2 years of in situ observations.
Design and characterization of SiC varactor-based phase shifters

Design and realization of two continuously tunable phase shifters for 1.4 GHz band is presented. Both circuits are based on SiC varactors, conceived to enable high-voltage, high-power operation, and suitable for application in the transmitter chain of reconfigurable radios. Experimental characterization shows, for the loaded line phase shifter, 74° maximum phase shift with insertion loss lower than 1 dB, and, for the reflective phase shifter, 90° maximum phase shift and insertion loss lower than 0.6 dB.
Esaim: Control, Optimisation and Calculus of Variations Generalized Solutions to Hybrid Dynamical Systems *

Several recent results in the area of robust asymptotic stability of hybrid systems show that the concept of a generalized solution to a hybrid system is suitable for the analysis and design of hybrid control systems. In this paper, we show that such generalized solutions are exactly the solutions that arise when measurement noise in the system is taken into account. The dates will be set by the publisher.
Comparative evaluation of the quality and homogeneity of different obturating systems using cone-beam computed tomography – An in vitro study

Aim: The aim of this study was to evaluate the homogeneity and quality of different obturating systems using cone-beam computed tomography (CBCT). Materials and Methods: One hundred and twenty extracted maxillary and mandibular molars were included in this study which was decoronated first and then dissected into palatal and distal roots. After working length determination, all the roots were biomechanically prepared with ProTaper universal system. The prepared roots were evaluated using CBCT, and volumetric analysis was done. Samples were then randomly divided into three groups corresponding to the obturation method used – cold lateral compaction technique, single-cone technique, and BeeFill 2 in 1 system. After obturation, CBCT imaging and volumetric analyses were performed again to compare and analyze the amount of volume of obturation in different obturating techniques. To standardize the volume, pre-and postobturation images were superimposed. To avoid errors, for each section, measurements were repeated three times and the means were calculated. Statistical Analysis Used: The data were statistically analyzed using one-way analysis of variance, followed by post hoc test. Results: Results showed a statistically significant difference of the single cone with lateral compaction and the BeeFill system (P < 0.001). Maximum volume of obturating material was found in BeeFill at all levels – Coronal, middle, and apical, followed by cold lateral compaction and single-cone technique (P < 0.001). Conclusion: It could be concluded that the thermoplasticized obturating technique can be a better choice for obturation rather than the single cone and lateral compaction technique.
University of Birmingham Observation of the b J/K decay

The observation of the decay Ξ − b → J /ψΛ K − is reported, using a data sample corresponding to an integrated luminosity of 3 fb − 1 , collected by the LHCb detector in pp collisions at centre-of-mass energies of 7 and 8 TeV. The production rate of Ξ − b baryons detected in the decay Ξ − b → J /ψΛ K − is measured relative to that of Λ 0 b baryons using the decay Λ 0 b → J /ψΛ . Integrated over the b -baryon transverse momentum p T < 25 GeV / c and rapidity 2 . 0 < y < 4 . 5, the measured ratio is f b where f Ξ − b and f Λ 0 b are the fragmentation fractions of b → Ξ − b and b → Λ 0 b transitions, and B represents the branching fraction of the corresponding b -baryon decay. The mass difference between Ξ − b and Λ 0 b baryons is measured to be
Fitness and performance classified according to body mass index and waist circumference for Canadian Forces personnel aged 50--59 years

Purpose: Examine the relationship between body mass index (BMI), Waist Circumference (WC), performance in the Canadian Forces (CF) EXPRES test, and the Five Common Tasks (5CT) fitness test for CF members 50-59 years. Hypothesis: Increasing BMI and WC are related to lower performance in the EXPRES and 5CT. Results: For males (n=127, mean BMI=27.7 kg/m(±3.4), mean WC=96.99 cm(±9.8 cm)), increasing BMI and WC correlated (p 102 cm. The results for females (n=27, mean BMI=25.8 kg/m(± 3.6), mean WC=84.5 cm(± 9.3 cm)) were inconclusive due to the sample size. Conclusion: For males, increasing BMI and WC were related to lower performance on some components of CF physical fitness testing. Additionally, the high percent of "Obese" individuals identifies and an alarming trend towards increased health risk.
Methods of assessment of urogenital atrophy and the implication of these in estimated prevalence rates: A review of the literature

Urogenital atrophy is thought to affect many peri and post-menopausal women, but lack of an objective, reproducible method to confirm the likely diagnosis, based on symptoms, means that accurate prevalence rates are not available. Background Urogenital atrophy is caused by lack of estrogen, most commonly due to the menopause. Symptoms frequently experienced include vaginal dryness, itching, burning, sexual difficulties and urinary problems, all of which can have a significant adverse effect on quality of life. Effective treatments are available for women with a confirmed diagnosis. The aim of this review is to determine whether a consistent diagnostic intervention exists, to support an accurate indication of prevalence. Materials and Methods This study is a review of the literature. Results A total of 1469 papers were identified on an initial search, including randomised controlled trials, cross sectional and cohort studies. By adoption of a systematic process, the number of papers in the final review was eight. There is inconsistent use of available assessment methods to diagnose urogenital atrophy in symptomatic women. There are no validated clinical assessment tools. Conclusion Absence of a defined intervention with which to confirm a diagnosis of urogenital atrophy, based on symptoms, influences research outcomes, but more importantly affects access to an accurate diagnosis and treatment, for affected women. This would ideally take place in a primary care setting.
Associations between tobacco and cannabis use and anxiety and depression among adults in the United States: Findings from the COVID-19 citizen science study

Background Little is known about whether people who use both tobacco and cannabis (co-use) are more or less likely to have mental health disorders than single substance users or non-users. We aimed to examine associations between use of tobacco and/or cannabis with anxiety and depression. Methods We analyzed data from the COVID-19 Citizen Science Study, a digital cohort study, collected via online surveys during 2020–2022 from a convenience sample of 53,843 US adults (≥ 18 years old) nationwide. Past 30-day use of tobacco and cannabis was self-reported at baseline and categorized into four exclusive patterns: tobacco-only use, cannabis-only use, co-use of both substances, and non-use. Anxiety and depression were repeatedly measured in monthly surveys. To account for multiple assessments of mental health outcomes within a participant, we used Generalized Estimating Equations to examine associations between the patterns of tobacco and cannabis use with each outcome. Results In the total sample (mean age 51.0 years old, 67.9% female), 4.9% reported tobacco-only use, 6.9% cannabis-only use, 1.6% co-use, and 86.6% non-use. Proportions of reporting anxiety and depression were highest for the co-use group (26.5% and 28.3%, respectively) and lowest for the non-use group (10.6% and 11.2%, respectively). Compared to non-use, the adjusted odds of mental health disorders were highest for co-use (Anxiety: OR = 1.89, 95%CI = 1.64–2.18; Depression: OR = 1.77, 95%CI = 1.46–2.16), followed by cannabis-only use, and tobacco-only use. Compared to tobacco-only use, co-use (OR = 1.35, 95%CI = 1.08–1.69) and cannabis-only use (OR = 1.17, 95%CI = 1.00–1.37) were associated with higher adjusted odds for anxiety, but not for depression. Daily use (vs. non-daily use) of cigarettes, e-cigarettes, and cannabis were associated with higher adjusted odds for anxiety and depression. Conclusions Use of tobacco and/or cannabis, particularly co-use of both substances, were associated with poor mental health. Integrating mental health support with tobacco and cannabis cessation may address this co-morbidity.
When Do Security Markets Aggregate Dispersed Information?

We attempt to replicate a seminal paper that offered support for the rational expectations hypothesis and reported evidence that markets with certain features aggregate dispersed information. The original results are based on only a few observations, and our attempt to replicate the key findings with an appropriately powered experiment largely fails. The resulting poststudy probability that market performance is better described by rational expectations than the prior information (Walrasian) model under the conditions specified in the original paper is very low. As a result of our failure to replicate, we investigate an alternate set of market features that combines aspects of the original experimental design. For these markets, which include both contingent claims and homogeneous dividend payments (as in many prediction markets), we do find robust evidence of information aggregation in support of the rational expectations model. In total, our results indicate that information aggregation in asset markets is fragile and should only be expected in limited circumstances. This paper was accepted by Bruno Biais, finance.
Human 3D Pose Estimation in the Wild : using Geometrical Models and Pictorial Structures

This paper addresses the problem of human pose estimation, given images taken from multiple dynamic but calibrated cameras. We consider solving this task using a part-based model and focus on the part appearance component of such a model. We use a random forest classifier to capture the variation in appearance of body parts in 2D images. The result of these 2D part detectors are then aggregated across views to produce consistent 3D hypotheses for parts. We solve correspondences across views for mirror symmetric parts by introducing a latent variable. We evaluate our part detectors qualitatively and quantitatively on a dataset gathered from a professional football game.
IMPACT OF TYPE 2 DIABETES IN NON ST-ELEVATION MYOCARDIAL INFARCTION (NSTEMI).

Objetives: The aim of this work is to expose the experience of our center in managing severe multi vessel coronary artery disease in diabetic NSTEMI patients. Methods: This is a retrospective study of 105 patients admitted for a high risk non ST-Elevation Myocardial Infarction (NSTEMI) to the cardiology department of the military hospital, Rabat, Morocco. Data was collected from january 2013 to december 2014. We enrolled patients in two groups: Group 1: diabetic patients (N 53) and Group 2: non diabetic patients (N 52). Results: The mean age was almost comparable between the 2 groups: 62 years in diabetics against 60 years in non-diabetics. The mean diabetes duration was about 8.6 years. Diabetic patients are more likely to develop arterial hypertension; smoking is the most important cardiovascular risk factor in non-diabetic group. Tri-truncular coronary lesion was more frequent in diabetics (55%), whereas non-diabetic patients had more mono-truncular lesions (53%). 59% of diabetic patients underwent PCI vs 53 % in non diabetic group, 26% of diabetic patients underwent CABG. 15% of diabetic group and 16% of non diabetic group were managed by medical treatment only. For in-hospital MACE, there were no signicant differences in outcomes between the 2 groups. (Group1 : 10,4% vs Group 2 : 10,5%, p :0,6). Conclusions: In diabetic NSTEMI patients, coronary artery disease was more severe; in our center, PCI was non inferior in term of intra hospital MACE compared to CABG.
Genetic Predisposition, Sedentary Behavior, and Incident Coronary Artery Disease: A Prospective Chinese Cohort Study

ABSTRACT Purpose Whether the association of sedentary behaviors with coronary artery disease (CAD) can be influenced by genetic susceptibility remains unclear. We aimed to investigate the joint and interplay effects between genetic risk and sedentary time (ST) and to further explore the extent to which the risk for CAD can be counteracted by reducing ST in different genetic groups. Methods This prospective cohort study included 39,164 Chinese adults without CAD history. Genetic susceptibility was quantified by a predefined polygenic risk score (PRS) with 540 genetic variants, and daily ST was assessed by questionnaire. We analyzed the modification effect of genetic risk on the association of ST with CAD using the Cox proportional hazards models. Results During a median follow-up of 11.60 yr, 1156 CAD events were documented. Higher ST and PRS were separately related to elevated CAD risk. Significant additive interaction was also observed (relative excess risk due to interaction: 0.77; 95% confidence interval [CI] = 0.27–1.28). Compared with participants with low genetic risk and low ST (<6 h·d−1), those with high genetic risk and high ST (≥10 h·d−1) had the highest CAD risk, with the hazard ratio (HR) and 95% CI of 4.22 (2.65–6.71). When stratified by genetic risks, participants with high ST had gradient increment of CAD risks across low, intermediate, and high genetic risk groups, with HR (95% CI) values of 1.21 (0.61–2.40), 1.57 (1.14–2.16), and 2.15 (1.40–3.31), respectively. For the absolute risk reduction, individuals with high genetic risk achieved the greatest benefit from low ST (Ptrend = 0.024). Conclusions Genetic susceptibility may synergistically interact with ST to increase CAD risk. Reducing ST could attenuate the CAD risk, especially among individuals with high genetic risk.
Power Motives and Core Self Evaluation as Correlates of Managerial Morality

More than ever before, educators are seeking innovative ways to improve students’ achievement,promote quality teaching, reduce cost and motivate students. Educational leaders, from heads todirectors, are all working harder than ever to become more effective at managing change andinnovation in the "Digital Age". Today, the large collection of media-rich teaching and everything fromeducational broadcasting is a good recipe for quality education.