Miracle-dz/UniFAR-FTUs huggingface dataset:
Link Prediction on a Network of Co-occurring MeSH Terms: Towards Literature-based Discovery

Summary Objectives:Literature-based discovery (LBD) is a text mining methodology for automatically generating research hypotheses from existing knowledge. We mimic the process of LBD as a classification problem on a graph of MeSH terms. We employ unsupervised and supervised link prediction methods for predicting previously unknown connections between biomedical concepts. Methods:We evaluate the effectiveness of link prediction through a series of experiments using a MeSH network that contains the history of link formation between biomedical concepts. We performed link prediction using proximity measures, such as common neighbor (CN), Jaccard coefficient (JC), Adamic / Adar index (AA) and preferential attachment (PA). Our approach relies on the assumption that similar nodes are more likely to establish a link in the future. Results:Applying an unsupervised approach, the AA measure achieved the best performance in terms of area under the ROC curve (AUC = 0.76),gfollowed by CN, JC, and PA. In a supervised approach, we evaluate whether proximity measures can be combined to define a model of link formation across all four predictors. We applied various classifiers, including decision trees, k-nearest neighbors, logistic regression, multilayer perceptron, naïve Bayes, and random forests. Random forest classifier accomplishes the best performance (AUC = 0.87). Conclusions:The link prediction approach proved to be effective for LBD processing. Supervised statistical learning approaches clearly outperform an unsupervised approach to link prediction.
Do Patients “Like” Good Care? Measuring Hospital Quality via Facebook

With the growth of Facebook, public health researchers are exploring the platform’s uses in health care. However, little research has examined the relationship between Facebook and traditional hospital quality measures. The authors conducted an exploratory quantitative analysis of hospitals’ Facebook pages to assess whether Facebook “Likes” were associated with hospital quality and patient satisfaction. The 30-day mortality rates and patient recommendation rates were used to quantify hospital quality and patient satisfaction; these variables were correlated with Facebook data for 40 hospitals near New York, NY. The results showed that Facebook “Likes” have a strong negative association with 30-day mortality rates and are positively associated with patient recommendation. These exploratory findings suggest that the number of Facebook “Likes” for a hospital may serve as an indicator of hospital quality and patient satisfaction. These findings have implications for researchers and hospitals looking for a quick and widely available measure of these traditional indicators.
Stromal Progesterone Receptors Mediate the Inhibitory Effects of Progesterone on Estrogen-Induced Uterine Epithelial Cell Deoxyribonucleic Acid Synthesis* *This work was supported by NIH Grants AG-13784 and HD-07857.

The role of epithelial and stromal progesterone (P) receptors (PR) in the regulation of uterine epithelial DNA synthesis by P was investigated by analyzing the four types of tissue recombinants prepared with uterine stroma (S) and epithelium (E) from wild-type (wt) and PR knockout (PRKO) mice: wt-S + wt-E, PRKO-S + PRKO-E, wt-S + PRKO-E, and PRKO-S + wt-E. 17-Beta estradiol (E2) stimulated DNA synthesis in all four types of tissue recombinants. On the other hand, P inhibited E2-induced DNA synthesis only in tissue recombinants prepared with wild-type (PR-positive) stroma (wt-S + wt-E or wt-S + PRKO-E) but not knockout (PR-negative) stroma (PRKO-S + wt-E or PRKO-S + PRKO-E). These results clearly demonstrate that the inhibitory effect of P on uterine epithelial DNA synthesis is mediated by stromal PR. Epithelial PR is neither necessary nor sufficient for P inhibition of E2-induced epithelial DNA synthesis.
Trace nitrogen-containing species in the offgas from two oil shale retorting processes.

Six non-H/sub 2/S sulfur species were identified and quantitated from two different retorting processes, a modified in situ process and an aboveground process. Carbonyl sulfide (COS), methyl mercaptan (CH/sub 3/SH), carbon disulfide (CS/sub 2/), thiophene, methylthiophene, and sulfur dioxide (SO/sub 2/) were determined by gas chromatography combined with a flame photometric detector. One of the in situ retorts produced the highest concentrations of sulfur species while the aboveground retort produced the least of the three retorts studied. However, other modified in situ retorts have been reported to produce relatively low concentrations of sulfur species. Variability in the quantitative data was attributed to variability both in sulfur content of the raw oil shales and in retort conditions. Possible reaction mechanisms were considered. The non-H/sub 2/S sulfur species comprise 0.4-6% of the low molecular weight sulfur species measured in the retort off-gases. Abatement strategies must consider the presence of these trace species if the air quality standards proposed by Colorado are to be maintained.
The 1974 Congressional Initiative in Budget Making

While passage of the Congressional Budget and Impoundment Control Act of 1974 had been proclaimed a major advance in redressing the congressional-presidential imbalance, knowledgeable participants and observers remain aware that passage of legislation itself does not guarantee congressional reassertion of leadership in fiscal matters without a corresponding performance. That a compromise between House and Senate versions of the legislation was forthcoming became known on June 5, 1974, when the Conference Committee announced reaching agreement. Supported by a massive staff effort, the conferees had labored long to reconcile HR 7130, passed December 5, 1973, with a Senate version of March 22, 1974. After passage by the House on June 18 and by the Senate on June 21 and a delayed enrollment, it became Public Law 93-344 (88 Stat 297). Senator Sam Irvin, chairman of the Government Operations Committee and Senate Floor Manager, had proclaimed this measure to be the most important piece of legislation with which he was involved in his culminating 20-year career in the Senate and "the finest example of the legislative process at work that I have witnessed. "' While the need for congressional budget reform had been recognized for decades, a major impetus during the 20-month congressional struggle with procedural reform was its concern for recouping * The new Congressional Budget and Impoundment Control Act of 1974, heralded by some as the most important budget reform measure since the Budget and Accounting Act of 1921, has the objective of enabling Congress to gain a better control over spending priorities and other aspects of the budget process. It provides for new congressional institutions, an improved analytical capability, a revised timetable with the fiscal year shifted to begin October 1, and a demand on the President to furnish additional budget data. It further curtails the President's authority to withhold appropriations. Its new Budget Committees, assisted by a new Congressional Budget Office, are to take the lead in establishing target relationship between appropriation totals and revenue expectations early in each session and then lead in reaffirming the congressional position, once appropriation totals are known just before the beginning of the new fiscal year. It also requires an overt congressional approval of any appropriation rescissions. New officials, tasked with carrying out the Act, concur in the difficulty of this undertaking because of the stringent time limitations, the complexity of forces to be reconciled, and the scope of decisions to be made.
Famiglie, mercato del lavoro e rischo sociali. Nascita di un figlio e rischi di transizione alla povertà tra le famiglie italiane

Child poverty and intergenerational transmission of social risks are features of the increase of social inequality occurred in the last two decades. In this paper, we study how in a sub-protective welfare model, as the Italian one, the households may enter poverty in concomitance with a child birth. Italian welfare state plays a reduced role in protecting families and their children against poverty, with limited money transfers and scarce childcare services. Furthermore, the process of labour market flexibilization «at the margins» produced a strong labour market segmentation, which hits again young people and young, newly formed families. In this regard, we ask firstly whether a child birth increase the probabilities of entering poverty; secondly, if the risk of being poor in concomitance of the birth of a child is higher among temporary workers households. Using longitudinal IT-Silc data (2004-2007) and applying Random Effects logit models and statistical matching, we show that families with new-born babies face higher poverty risks (threshold at 60% of median income) than their counterpart, with possibly negative consequences on future children's life chances. Our empirical evidence shows that in Italy labour marker precariousness and economic poverty represent quite often two sides of the same coin: the Italian welfare state provides young households with no sufficient resources te cope with the child birth event, thus failing to prevent the risk of entering poverty with the parallel deepening in intergenerational transmission of social and econornic risks.
Online Source Rate Control for Adaptive Video Streaming Over HSPA and LTE-Style Variable Bit Rate Downlink Channels

Online source rate control (RC) is designed for video streaming over high-speed packet access (HSPA) and Long-Term Evolution (LTE)-style variable bit rate (VBR) downlink channels. The problem is formulated as the adaptive adjustment of the operational mode of a video encoder based on the buffer overflow probability (BOP) feedback received from the radio link control (RLC) layer at the base station (BS). This allows us to maximize the attainable visual quality while keeping the transmitter BOP below a desired threshold and maintaining a video delay as low as possible. We derive an online measurement-based BOP estimation model for the RLC buffer, which is capable of operating with no prior knowledge of the channel variations and of the video characteristics. Based on this estimation model, an online adaptive RC algorithm is proposed to seamlessly adapt the bit stream to the characteristics of VBR channels. Our experiments are conducted in multiuser scenarios using VBR video encoding combined with adaptive modulation and coding (AMC) in the transceiver. The results demonstrate that the proposed source RC regime supports near-instantaneous yet smooth bit stream adaptability, which makes it useful for HSPA and LTE-style systems for the sake of accommodating unknown video traffic characteristics and dynamically fluctuating propagation conditions.
Synchronous Hodgkin Lymphoma and Papillary Thyroid Carcinoma: The Importance of Positron Emission Tomography/Computed Tomography (PET/CT)

We report a 50-year-old male with synchronous Hodgkin lymphoma (HL) and papillary thyroid carcinoma (PTC). The patient was diagnosed as having HL of the nodular sclerosis type on excisional biopsy of an enlarged right scalene node in March 2018. After further examinations including bone marrow biopsy and positron emission tomography/computed tomography (PET/CT) with 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG), he was classified as having stage IVA HL with bone marrow involvement. The patient’s medical history was unremarkable for any chronic disease or previous throid disease. He had no history of irradiation to head and neck, nor had any regular medications. Her mother had a diagnosis of breast carcinoma.
A 3-nW 9.1-ENOB SAR ADC at 0.7 V and 1 kS/s

This paper presents a 10-bit SAR ADC in 65 nm CMOS for medical implant applications. The ADC consumes 3-nW power and achieves 9.1 ENOB at 1 kS/s. The ultra-low-power consumption is achieved by using an ADC architecture with maximal simplicity, a small split-array capacitive DAC, a bottom-plate sampling approach reducing charge injection error and allowing full-range input sampling without extra voltage sources, and a latch-based SAR control logic resulting in reduced power and low transistor count. Furthermore, a multi-Vt circuit design approach allows the ADC to meet the target performance with a single supply voltage of 0.7 V. The ADC achieves a FOM of 5.5 fJ/conversion-step. The INL and DNL errors are 0.61 LSB and 0.55 LSB, respectively.
Development of a Micro-Retarding Potential Analyzer for High-Density Flowing Plasmas

The development of Retarding Potential Analyzers (RPAs) capable of measuring highdensity stationary and flowing plasmas is presented. These new plasma diagnostics address the limitations of existing RPAs and can operate in plasmas with electron densities in excess of 1x10 m. Such plasmas can be produced by high-powered Hall Thrusters, Pulsed Plasma Thrusters (PPTs), and other plasma sources. The Single-Channel micro-Retarding Potential Analyzer (SC-μRPA) developed has a minimum channel diameter of 200 μm, electrode spacing on the sub-millimeter scale and can operate in plasmas with densities of up to 1x10 m. The electrode series consists of 100 μm thick molybdenum electrodes and Teflon insulating spacers. The alignment process of the channel, as well as the design and fabrication of the stainless steel outer housing, the Delrin insulating tube, and all other μRPA components are detailed. To expand the applicability of the SC-μRPA to densities above 1x10 m a low transparency Microchannel Plate (MCP) has been incorporated in the design of a Multi-Channel micro-Retarding Potential Analyzer (MC-μRPA). The current collection theory for the SC-μRPA and the MC-μRPA is also derived. The theory is applicable to μRPAs with arbitrary channel length to diameter ratios and accounts for the reduction of ion flux due to the microchannel plate in the case of the MC-μRPA, due to absorption of ions by channel walls, and due to the applied potential. Current-voltage curves are obtained for incoming plasma flows that range from near-stationary to hypersonic, with temperatures in the range of 0.1 to 10 eV, and densities in the range of 1x10 m to 1x10 m. The SC-μRPA current collection theory is validated by comparisons with the classical RPA theory and particle-in-cell simulations. Determination of unknown plasma properties is based on a fuzzy-logic approach that uses the generated current-voltage curves as lookup tables.
Screening of biomethane production potential from dominant microalgae

ABSTRACT The use of microalgae for biomethane production has been considerably increasing during the recent years. In this study, four dominant species belonging to the genera Scenedesmus, Chlorella, Dunaliella and Nostoc were selected. The influence of different genera with several morphological, structural and physicochemical characteristics on methane production was assessed in biochemical methane potential (BMP) tests. The ultimate methane yield values were 332 ± 24, 211 ± 2, 63 ± 17 and 28 ± 10 mL CH4/g VSadded for Scenedesmus obliquus, Chlorella sorokiniana, Dunaliella salina and Nostoc sp. , respectively. The highest methane production was achieved by microalga species that had no complex cell wall or wall basically composed by proteins and simple sugars such as in S. obliquus, whereas lower methane yields were found for D. salina and Nostoc sp. , due to the salinity effects and cell wall composition in terms of complex polysaccharide and glycolipid layers, respectively. Kinetic constant values obtained in the BMP tests ranged between 1.00 ± 0.08 and 0.097 ± 0.005 days−1 for D. salina and S. obliquus, respectively.
Increased Susceptibility of IgA-Deficient Mice to Pulmonary Francisella tularensis Live Vaccine Strain Infection

ABSTRACT Francisella tularensis, the causative agent of tularemia, is most deadly in the pneumonic form; therefore, mucosal immunity is an important first line of defense against this pathogen. We have now evaluated the lethality of primary F. tularensis live vaccine strain (LVS) pulmonary infection in mice that are defective in IgA (IgA−/− mice), the predominant mucosal Ig isotype. The results showed that IgA−/− mice were more susceptible than IgA+/+ mice to intranasal F. tularensis LVS infection, despite developing higher levels of LVS-specific total, IgG, and IgM antibodies in the bronchoalveolar lavage specimens following infection. In addition, the absence of IgA resulted in a significant increase in bacterial loads and reduced survival. Interestingly, IgA−/− mice had lower pulmonary gamma interferon (IFN-γ) levels and decreased numbers of IFN-γ-secreting CD4+ and CD8+ T cells in the lung on day 9 postinfection compared to IgA+/+ mice. Furthermore, IgA−/− mice displayed reduced interleukin 12 (IL-12) levels at early time points, and supplementing IgA−/− mice with IL-12 prior to LVS challenge induced IFN-γ production by NK cells and rescued them from mortality. Thus, IgA−/− mice are highly susceptible to primary pulmonary LVS infections not only because of IgA deficiency but also because of reduced IFN-γ responses.
Electrocardiographic screening in athletes: the time is now for universal screening

Regular physical exercise reduces cardiovascular morbidity and mortality. A small proportion of athletes, however, are at increased risk of exercise-related sudden cardiac death (SCD) as a result of quiescent cardiac anomalies. The preventable nature of such deaths has prompted the medical and sporting governing bodies to recommend preparticipation cardiovascular screening (PPS) in young athletes (⩽35 years) to permit the identification of potentially fatal disorders. Although evidence from the Italian experience suggests that electrocardiographic screening of young athletes has led to a significant reduction in SCD from cardiomyopathies, considerable controversy relating to the efficacy, cost-effectiveness and the impact of false-positive results of PPS still exists. This review presents an appraisal of all the available scientific evidence, attempting to resolve the concerns of the antagonists and examine how PPS compares with the World Health Organization screening criteria, providing compelling justifications for the implementation of universal PPS in young, competitive athletes.
Chemoresistance in ovarian cancer linked to expression of microRNAs

Abstract We evaluated the differential expression of several microRNAs (miRNAs) among malignant cells in ascites and matched omental metastasis in patients with epithelial ovarian cancer (EOC). Ascites and omental tumors were collected prospectively from five patients who were undergoing primary surgical cytoreduction. Patient samples were processed and treated with carboplatin, paclitaxel and combination chemotherapy. Cell viability was evaluated and miRNA profiling was performed on both tumor cells from ascites fluid and omental cake. Quantitative real-time PCR (RT-q-PCR) and western blots were used to evaluate expressions of miRNA-21 and miRNA -214 and associated proteins. Malignant cells in ascites showed greater cell viability when treated with carboplatin compared to omental metastasis. A significant up-regulation of miRNA-21 and miRNA-214 was observed in malignant cells of ascites compared to omental metastasis; this was confirmed by both cell viability assay and RT-q-PCR. Ours is the first report that demonstrates significant up-regulation of miRNA-21 and miRNA-214 in tumor cells from ascites of patients with EOC compared to omental metastasis. This finding has important implications for intrinsic carboplatin resistance in these patients.
Parenting behaviors and the onset of smoking and alcohol use: a longitudinal study.

OBJECTIVE To identify which specific parenting behaviors are associated with the onset of alcohol and tobacco use and how they are associated. DESIGN Prospective cohort study of two groups of preadolescents surveyed annually, the first group for 4 years, the second for 3 years. SETTING Two public school districts in Southern California. SUBJECTS 1034 fifth graders and 1266 seventh graders began the study after obtaining parental consent to complete surveys in a classroom setting. By the last measurement, attrition was 37 and 38% for the two cohorts, respectively. MAIN OUTCOME MEASURES The onset of tobacco or alcohol use in the last month. RESULTS Children who reported that parents spent more time with them and communicated with them more frequently had lower onset rates of using alcohol and tobacco in the last month. These parental interactions lead to more positive relationships with their children. Parental monitoring and positive relations were protective factors for disruptive behavior and the selection of substance-using friends. Disruptive behavior increased the odds of adolescents drinking in the last month approximately twofold and of smoking in the last month two to fourfold. CONCLUSIONS This study provides further evidence that parenting behaviors are significant precursors to adolescent disruptive behavior, vulnerability to peer pressure, and subsequent substance use. Parents should be targeted in future substance use prevention programs, before their children reach adolescence.
Identification of novel cytogenetic markers with prognostic significance in a series of 968 patients with primary myelodysplastic syndromes.

BACKGROUND AND OBJECTIVES The main prognostic factors in myelodysplastic syndromes (MDS) are chromosomal abnormalities, the proportion of blasts in bone marrow and number and degree of cytopenias. A consensus-defined International Prognostic Scoring System (IPSS) for predicting outcome and planning therapy in MDS has been developed, but its prognostic value in a large and independent series remains unproven. Furthermore, the intermediate-risk cytogenetic subgroup defined by the IPSS includes a miscellaneous number of different single abnormalities of uncertain prognostic significance at present. The main aim of the present study was to identify chromosomal abnormalities with a previously unrecognized good or poor prognosis in order to find new cytogenetic markers with predictive value. DESIGN AND METHODS We report the cytogenetic findings in a series of 968 patients with primary MDS from the Spanish Cytogenetics Working Group, Grupo Cooperativo Español de Citogenética Hematológica (GCECGH). RESULTS In this series of 968 MDS patients, we found various cytogenetic aberrations with a new prognostic impact. Complex karyotype, -7/7q- and i(17q) had a poor prognosis; normal karyotype, loss of Y chromosome, deletion 11q, deletion 12p and deletion 20q as single alterations had a good prognosis. Intermediate prognosis aberrations were rearrangements of 3q21q26, trisomy 8, trisomy 9, translocations of 11q and del(17p). Finally, a new group of single or double cytogenetic abnormalities, most of which are considered rare cytogenetic events and are usually included in the intermediate category of the IPSS, showed a trend to poor prognosis. INTERPRETATION AND CONCLUSIONS This study suggests that some specific chromosomal abnormalities could be segregated from the IPSS intermediate-risk cytogenetic prognostic subgroup and included in the low risk or in the poor risk groups.