Miracle-dz/UniFAR-FTUs huggingface dataset:
Interleukin-4 Inhibition of Colon and Breast Carcinoma Cell Growth by Updated

Within human carcinomas, there is often an infiltration of lymphocytes and other cells of the immune system. A variety of cytokines are produced by such cells that could have a paracrine influence on the growth of tumor epithelium. The effect of one of these cytokines, interleukin-4 ( 11.-4). on human breast and colon cancer cell lines was therefore examined. 11-4 inhibited the growth of human colon (HT 29) and breast [MCF-7 wild type (MCF-7 WT), MCF-7 Adriamycin-resistant (MCF-7r), MDA-MB231, and MDA-MB-468) carcinoma cells in culture. Competitive binding of '"I-IL-4 demonstrated the presence of 2000 high affinity IL-4-binding sites on HT 29 cells. The Kt for specific binding of '"I-IL-4 to HT 29 cells was 77 p\i. Further studies were conducted on the estrogen-depend ent MCF-7 WT and estrogen-independent MDA-MB-231 breast carci noma lines. Concentrations of 11-4 of 10-100 IIM were required to significantly inhibit growth of these carcinoma cell lines; e.g., with MCF7 WT cells, half-maximal inhibition of growth occurred at 20 UM IL-4. Specific binding of l2SML-4 was detected to MCF-7 WT and MDA-MB231 cells, but the low level of binding precluded Scatchard analysis. II.4 inhibited 90% of the 17/Ã®-estradiol-stimulated growth of MCF-7 WT cells in a dose-dependent manner but without a change in estrogen receptor expression. Inhibition of growth by IL-4 was less in the absence of estrogens. Combined treatment with IL-4 and other known inhibitors of breast carcinoma cell growth [transforming growth factor-jSi (TGF-#i) and the antiestrogen tamoxifen) showed additive inhibition. The hormoneindependent cell lines MCF-7r and MDA-MB-231 were additively inhib ited by IL-4 and TGF-0,. This was not the case with MDA-MB-468 cells in which inhibition by IL-4 and ! (â€¢! â€¢'-/:(, was of similar magnitude but no significantly greater effect was observed on combined treatment. No secretion of IL-4 was detected from these cell lines either basally or on treatment with TGF-ÃŸ,or tamoxifen, and we conclude that IL-4 is a nonautocrine inhibitor of breast carcinoma cell growth.
Nonlinear Shock Acceleration and Photon Emission in Supernova Remnants

We have extended a simple model of nonlinear diffusive shock acceleration to include the injection and acceleration of electrons and the production of photons from bremsstrahlung, synchrotron, inverse-Compton, and pion-decay processes. We argue that the results of this model, which is simpler to use than more elaborate ones, offer a significant improvement over test-particle, power-law spectra which are often used in astrophysical applications of diffusive shock acceleration. With an evolutionary supernova remnant (SNR) model to obtain shock parameters as functions of ambient interstellar medium parameters and time, we predict broadband continuum photon emission from supernova remnants in general, and SN 1006 in particular, showing that our results compare well with the more complete time-dependent and spherically symmetric nonlinear model of Berezhko, Ksenofontov, & Petukhov. We discuss the implications nonlinear shock acceleration has for X-ray line emission and use our model to describe how ambient conditions determine the TeV/radio flux ratio, an important parameter for γ-ray observations of radio SNRs.
Characterization of Nonlinear Optical Crosstalk in Silicon Nanowaveguides

We investigate optical crosstalk on a signal in a silicon nanowaveguide due to the presence of another signal by direct radio frequency crosstalk level measurements in a pump-probe configuration and by bit-error-rate-based characterization. We quantify this degradation as a function of the modulation frequency and power of the auxiliary signal. Our results indicate that two-photon and free-carrier absorption are primary facilitators of crosstalk in silicon nanowaveguides.
TOWARDS A HUMAN PERCEPTUAL MODEL FOR 3D SOUND LOCALIZATION

This paper describes the theoretical fundamentals and the preliminary results of the implementation of a perceptual model for human sound localization for the evaluation of 3D audio systems. Recent work undertaken in ISVR33 has led to the development of a biologically inspired auditory signal processing model that gives remarkable accuracy in the prediction of human localization of acoustic sources. Nevertheless, the model relies only on some auditory cues, i.e. the binaural cues, and as a consequence is able to predict only the location of sources in the horizontal plane. This paper reviews the basis of the previous model and presents preliminary results of an enhanced perceptual model that takes into consideration other cues, such as the spectral and dynamic cues, in addition to the classical binaural cues, in order to predict the location of 3D sounds.
3. THE EFFECT OF UNCERTAINTY IN GENOTYPE STATE ON THE INFERENCE OF VQTLS

##An example using dglm.Pvalues(.) with 200 simulated observations set.seed(123) require(dglm) n = 200 a <rbinom(n, 1, 0.5) ##Covariate for additive genetic effects sex <rbinom(n, 1, 0.5) ##Covariate for a non-genetic effect add.effect = 0 sex.effect = 1 res.var = exp( a*add.effect ) ##Residual variance y <10 + a*add.effect + sex*sex.effect + rnorm(n ,0 , sqrt(res.var)) ##The additive genetic effect must be given first in the following formula d.fit <dglm( formula = y ~ a + sex, dformula = ~ a ) P.values <dglm.Pvalues( d.fit ) print( P.values )
Power-Efficient Continuous-Flow Memory-Based FFT Processor for WiMax OFDM Mode

This paper presents a fast Fourier transform (FFT) processor suitable for IEEE 802.16e (WiMax) OFDM mode. FFT/IFFT processors are very crucial in OFDM transceivers and they usually consume considerable power as well as occupy large area. The proposed FFT processor combines the pipelined architecture and the memory-based architecture so that it can operate at the sample rate and thus achieve power efficiency. The processor is based on the multipath delay commutator architecture with high-radix arithmetic units and two main memories for input buffering, intermediate storage, and output reordering. A proposed conflict-free memory addressing strategy makes possible continuous-flow FFT processing. Simulation results show that it achieves a 29% saving in power consumption.
The Geography of Transit Crime

The link between the social and physical environment and transit crime is an important one, but it is not well understood or explored. This study explores the environmenttransit crime connection by examining in depth the relation between crime incidence at the stations along a light-rail line in Los Angeles and the social and physical characteristics of the stations and their neighborhoods. The study employs a mix of qualitative and quantitative methods to analyze crime statistics, census and ridership data, and built environment data. It documents and evaluates the geography of crime along this light-rail line as well as the impact of sociodemographic and environmental attributes on crime incidence at the station.
A Systematic Review of Osteoporosis Health Beliefs in Adult Men and Women

Osteoporosis is major public health concern affecting millions of older adults worldwide. A systematic review was carried out to identify the most common osteoporosis health beliefs in adult men and women from descriptive and intervention studies. The Osteoporosis Health Belief Scale (OHBS) and Osteoporosis Self-efficacy Scale (OSES) evaluate osteoporosis health beliefs, including perceived susceptibility and seriousness, benefits, barriers, and self-efficacy of calcium and exercise, and health motivation, and their relationship to preventive health behaviours. A comprehensive search of studies that included OHBS and OSES subscale scores as outcomes was performed. Fifty full-text articles for citations were reviewed based on inclusion criteria. Twenty-two articles met the inclusion criteria. Greater perceived seriousness, benefits, self-efficacy, health motivation, and fewer barriers were the most common health-belief subscales in men and women. Few studies were interventions (n = 6) and addressed osteoporosis health beliefs in men (n = 8). Taking health beliefs into consideration when planning and conducting education interventions may be useful in both research and practice for osteoporosis prevention and management; however, more research in this area is needed.
Biodiversity, Biotechnology, and Institutions Among Crops:: Situation and Outlook

Biodiversity, in all of its complexity, is threatened by a multitude of modern forces. In the first section of this article, some critical forces are described which lead to a reduction of biodiversity. The possible contribution of emerging agricultural biotechnologies to a reduction of biodiversity is investigated. Special emphasis is given to the future role of new biotechnologies and genetic engineering in plant production and their influence on the diversity of the overall genetic base of plant life--what we will refer to here as plant genetic resources. At the same time, much of what will be discussed applies equally to agricultural livestock and other forms of animal life. Emerging biotechnologies are influenced by technological, legal and social factors. Genetic resources, research structures, technological progress, seed markets and intellectual property rights interact strongly. These interactions shall be described in the second section of this article. A revision of international legal codes to.
Machine translation based data augmentation for Cantonese keyword spotting

This paper presents a method to improve a language model for a limited-resourced language using statistical machine translation from a related language to generate data for the target language. In this work, the machine translation model is trained on a corpus of parallel Mandarin-Cantonese subtitles and used to translate a large set of Mandarin conversational telephone transcripts to Cantonese, which has limited resources. The translated transcripts are used to train a more robust language model for speech recognition and for keyword search in Cantonese conversational telephone speech. This method enables the keyword search system to detect 1.5 times more out-of-vocabulary words, and achieve 1.7% absolute improvement on actual term-weighted value.
Towards Autonomous System Topology Aware Relay Service Scheme

Several studies have found some properties of Internet such as Triangle Inequality Violations (TIVs). The studies have reported the existence of TIV in the Internet delay space. Triangle inequality violations that are important to peer-to-peer applications can be leveraged to build overlay routing to improve peer-to-peer performance. How to select relay nodes becomes a crucial factor to overlay routing. In this paper, we propose a scheme called Relay Service Scheme (RSS) that takes AS connecting degree and AS valley-free counts into account. We then verify the performance of the scheme with available Internet delay data set. The results demonstrate that AS connecting degree and AS valley-free counts are meaningful to relay server selection and can be utilized in building relay service to decrease about 33%-50% probing throughput in contrast to ASAP as well as improve P2P performance. It is the first scheme to pick up relay as stable and reusable servers to form a relay network. It is believed that the advantage can be used by network operator to arrange the relay servers at proper location and provide the P2P applications both good QoS performance and low overhead.
CPAP and measures of cardiovascular risk in males with OSAS

Obstructive sleep apnoea syndrome (OSAS) has been associated with hypertension, stroke and myocardial ischaemia in epidemiological and observational studies. Continuous positive airway pressure (CPAP) is the treatment of choice for OSAS, but the impact of this intervention on established risk factors for cardiovascular disease remains incompletely understood. A total of 102 males with moderate-to-severe OSAS were randomised to therapeutic (n = 51) or subtherapeutic (n = 51) CPAP treatment for 4 weeks to investigate the effects of active treatment on 24-h urinary catecholamine excretion, baroreflex sensitivity (BRS), arterial stiffness (augmentation index) and 24-h ambulatory blood pressure (ABP). After 4 weeks of therapeutic CPAP, significant reductions were seen in urine normetanephrine excretion (from mean±sd 179.7±80.1 to 132.7±46.5 µmol·mol−1 creatinine) and augmentation index (from 14.5±11.3 to 9.1±13.8%) compared with the subtherapeutic control group. Furthermore, therapeutic CPAP significantly improved BRS (from 7.1±3.3 to 8.8±4.2 ms·mmHg−1) and reduced mean arterial ABP by 2.6±5.4 mmHg. In conclusion, treatment of obstructive sleep apnoea with continuous positive airway pressure may lower cardiovascular risk by reducing sympathetic nerve activity, ambulatory blood pressure and arterial stiffness and by increasing sensitivity of the arterial baroreflex.
Effect of head impacts on diffusivity measures in a cohort of collegiate contact sport athletes

Objective: To determine whether exposure to repetitive head impacts over a single season affects white matter diffusion measures in collegiate contact sport athletes. Methods: A prospective cohort study at a Division I NCAA athletic program of 80 nonconcussed varsity football and ice hockey players who wore instrumented helmets that recorded the acceleration-time history of the head following impact, and 79 non–contact sport athletes. Assessment occurred preseason and shortly after the season with diffusion tensor imaging and neurocognitive measures. Results: There was a significant (p = 0.011) athlete-group difference for mean diffusivity (MD) in the corpus callosum. Postseason fractional anisotropy (FA) differed (p = 0.001) in the amygdala (0.238 vs 0.233). Measures of head impact exposure correlated with white matter diffusivity measures in several brain regions, including the corpus callosum, amygdala, cerebellar white matter, hippocampus, and thalamus. The magnitude of change in corpus callosum MD postseason was associated with poorer performance on a measure of verbal learning and memory. Conclusion: This study suggests a relationship between head impact exposure, white matter diffusion measures, and cognition over the course of a single season, even in the absence of diagnosed concussion, in a cohort of college athletes. Further work is needed to assess whether such effects are short term or persistent.
Scaling Effects of Inverter-Induced Bearing Currents in AC Machines

In this survey paper, we show by straightforward mathematical scaling considerations that small inverter-fed ac motors of up to typical 20 kW at 1500/min are likely to suffer from discharge (electric discharge machining) bearing currents, whereas larger motors are likely to be subjected to high-frequency (HF) circulating bearing currents. When comparing motors that operate at the same voltage level, the resulting bearing-current density is high for very small and very large motors. Smaller values occur in between these two extremes with medium size motors in the range of 10-100 kW. Therefore, electric bearing insulation is useful for larger motors to interrupt the HF circulating bearing-current path, whereas small motors need rotor shielding, common-mode voltage filters, or hybrid bearings.
The Mechanism of the Word-Frequency Effect on Recognition Memory 1

The better recognition memory for rare as compared to frequently used words was shown to be unrelated to difference in association value, imagery, concreteness, or any change in phenomenal frequency due to exposure on the test list. But a manipulation substantially, modified recognition scores. Words that were exposed just prior to the learning task for ostensibly unrelated purposes were much less well recognized than ones not so exposed. ' The frequency-recognition effect was thus simulated in the laboratory by manipulating situational frequency.
On the orders of Primitive Permutation Groups

CHERYL E. PRAEGE R AN JAD N SAXLThe proble omf bounding the order of a permutation grou G ipn terms of itsdegree n was one of the central problem of 19tsh century group theory (see [4]) It.is closely relate to thde 1860 Grand Prix proble of them Pari s Academy but it, shistory goe isn fact much further back (see e.g an. [3]d [10]), [1] . The hear of thteproblem is of course the case where G a is primitiv e group. The best result here is dueto A. Bocher t [2] if: G is primitiv ane d A
Time to Digital Converter used in ALL digital PLL

i ACKNOWLEDGEMENTS I would like to thank: Professor Li-Rong Zheng for giving me the opportunity to do my master thesis project in IPACK group at KTH. Dr. Fredrik Jonsson for providing me with the interesting topic and guiding me for the overall research and plan. Dr. Jian Chen for answering all my questions and making the completion of the project possible. in IPACK group for the discussion and valuable suggestions during the thesis work. My mother Xiu-Yun Zheng and my husband Ming-Li Cui for always supporting and encouraging me. ii ABSTRACT This thesis proposes and demonstrates Time to Digital Converters (TDC) with high resolution realized in 65-nm digital CMOS. It is used as a phase detector in all digital PLL working with 5GHz DCO and 20MHz reference input for radio transmitters. Two kinds of high resolution TDC are designed on schematic level including Vernier TDC and parallel TDC. The Sensed Amplifier Flip Flop (SAFF) is implemented with less than 1ps sampling window to avoid metastability. The current starved delay elements are adopted in the TDC and the conversion resolution is equal to the difference of the delay time from these delay elements. Furthermore, the parallel TDC is realized on layout and finally achieves the resolution of 3ps meanwhile it consumes average power 442µW with 1.2V power supply. Measured integral nonlinearity and differential nonlinearity are 0.5LSB and 0.33LSB respectively.
A mechanistic study of the initial stage of the sintering of sol-gel derived silica nanoparticles

Dried silica gel powders were prepared by acid catalyzed controlled hydrolysis followed by polycondensation of tetraethyl orthosilicate (TEOS) in 1:1 by volume water-alcohol solution. The dried powders were pressed and isothermally heat treated over the temperature range of 200-600 o C. The mechanism of sintering of silica-gel particles during the initial stage of heating has been delineated and related to the formation of –Si-O-Sisiloxane bonds among the silica particles. This is experimentally substantiated by detailed diffusion reflectance infrared Fourier transformed spectroscopy (DRIFT) and thermo gravimetric/differential thermal (TG/DSC) analyses.
Broadening the Scope of Research on Emotion Regulation Strategies and Psychopathology

Despite the increasing interest in the study of emotion regulation strategies and psychopathology, researchers have predominantly focused on covert emotion regulation strategies—that is, those strategies that occur within the individual (e.g., cognitive reappraisal, suppression). Conversely, less attention has been devoted to the examination of the relationship between psychopathology and overt emotion regulation strategies (e.g., drinking alcohol, seeking advice). This has resulted in a limited understanding of the complex repertoire of emotion regulation strategies that individuals possess, and how patterns in the use of strategies might relate to psychopathology. We asked 218 undergraduates to report on their habitual use of 15 covert and overt emotion regulation strategies and symptoms of seven different mental disorders. Overt strategies were associated with symptoms and, at times, they predicted psychopathology above and beyond the more frequently studied covert strategies. These findings have implications for developing a more sophisticated understanding of patterns of adaptive and maladaptive emotion regulation.
Enhancement of bandpass sampling efficiency in direct RF subsampling receivers: application to multiband GPS subsampling receiver

In this paper, a new method is proposed to enhance the efficiency of band-pass subsampling for multi-band RF signals in order to relax design specifications for Software Defined Radio receivers. Hence, analytical formulations are defined to calculate the minimum valid sub-sampling frequency by adding specific guard bands around RF signal bands in order to overcome implementation imperfections and reduce aliasing caused by different noises. Upper and lower guard bands are derived from the specifications of the band-pass anti-aliasing filter implemented before sampling in order to restrict bandwidth and achieve image rejection. The proposed method was validated for the case of a multiband L1/L2/L5 GPS subsampling receiver. ADS simulation results showed valid design with 121.3088 MHz of subsampling frequency and third order anti-aliasing RF filter.
RFDA: Reliable framework for data administration based on split-merge policy

Emerging technologies in cloud environment have not only increased its use but also posed some severe issues. These issues can cause considerable harm not only to data storage but also to the large amount of data in distributed file structure which are being used in collaborative sharing. The data sharing technique in the cloud is prone to many flaws and is easily attacked. The conventional cryptographic mechanism is not robust enough to provide a secure authentication. In this paper, we overcome this issue with our proposed Reliable Framework for Data Administration (RFDA) using split-merge policy, developed to enhance data security. The proposed RFDA performs splitting of data in a unique manner using 128 AES encryption key. Different slots of the encrypted key are placed in different places of rack servers of different cloud zones. The effectiveness and efficiency of the proposed system are analyzed using comparative analysis from which it is seen that the proposed system has outperformed the existing and conventional security standard.
Variational Limits of K-nn Graph Based Functionals on Data Clouds

We consider i.i. d. samples x1,. , xn from a measure ν with density supported on a bounded Euclidean domain D ⊆ R d where d ≥ 3. A graph on the point cloud is obtained by connecting two points if one of them is among the k-nearest neighbors of the other. Our goal is to study consistency of graph based procedures to clustering, classification and dimensionality reduction by studying the variational convergence of the graph total variation associated to such k-NN graph. We prove that provided k := kn scales like n ≫ kn ≫ log(n), then the Γ-convergence of the graph total variation towards an appropriate weighted total variation is guaranteed.
The aesthetics of StripeMaps: being small and beautiful

Maps are a very powerful form of information visualization. Beside their main purpose to communicate often very complex relationships between elements of some space, "good" maps are often perceived as aesthetically pleasing and beautiful. Maps are collected for those reasons; since centuries and ages they are "beautiful" --over all trends. Cartography, the study and practice of making maps, has long tradition. Even today, most of the maps, e.g., road maps and public you-are-here maps, are still crafted by professional cartographers. However, maps do require space to be displayed while mobile and wearable devices are getting smaller and smaller. This presents new challenges in cartography, as designing aesthetic user interfaces is an important aspect in the area of HCI. With StripeMaps we present a technique to bring maps to very small displays without destroying their utility and beauty. In this workshop paper we discuss our design considerations in depth and open up the discussion for alternative approaches.