Miracle-dz/UniFAR-FTUs huggingface dataset:
Collaboration in Pennsylvania: Rapidly spreading improved chronic care for patients to practices

Introduction: Pennsylvania's Improving Performance in Practice (IPIP) program is administered by the Pennsylvania (PA) chapters of the American Academy of Family Physicians, American College of Physicians, and American Academy of Pediatrics. The project has provided coaching, monthly measurement, and patient registry support for 155 primary‐care practices that participate in the 3‐year Pennsylvania Chronic Care Initiative led by the PA Governor's Office of Health Care Reform. Methods: Practices participating in this case study are attending regional Breakthrough Series collaboratives and submitting monthly narrative and clinical outcomes reports. The approaches to education include in‐person learning sessions with multidisciplinary practice teams, on‐site practice coaching, conference calls, and regular feedback of performance data. More than half will receive financial incentives from more than a dozen participating insurers after becoming nationally recognized Patient Centered Medical Homes by the National Committee for Quality Assurance (NCQA). Results: In the first 6 months, practices showed improvement in diabetes process measures and a high level of engagement in the improvement process. Discussion: Early data reporting, practice preparation for the first learning session, monthly narrative reports from practices, and clear and concrete change packages all seem integral to the improvement process. The future of the PA Chronic Care Initiative will include spreading to more practices and moving beyond the initial work in diabetes and asthma to other aspects of primary care, including prevention.
Protective Effects of Radix Rosa laevigata against Propionibacterium acnes and Lipopolysaccharide-Induced Liver Injury

We investigated the effects of an extract of Radix Rosa laevigata (R. R. laevigata) on Propionibacterium acnes (P. acnes) and lipopolysaccharide (LPS)-induced acute liver injury. The plasma alanine aminotransferase (ALT) activity was significantly elevated by an intravenous injection of heat-killed P. acnes at a dose of 0.4 mg/mouse and then with LPS at 0.1 μg/mouse after 5 d. However, the elevated ALT activity was significantly reduced by the administered of R. R. laevigata (125 and 500 mg/kg/d) for 7 d before the LPS injection. In addition, the extract treatment reduced the number of liver mononuclear cells (MNCs), and malondialdehyde (MDA) and nitric oxide (NO) contents, but improved the liver oxygen radical absorbance capacity (ORAC) and mitochondrial membrane potential. Moreover, the chemical profile of R. R. laevigata was performed by high-performance liquid chromatography (HPLC) and the main peaks were identified as a series of polyphenol compounds which had been confirmed as the significantly active components by their anti-oxidative and NO inhibitory effects. These results suggest that the extract of R. R. laevigata offered good efficacy for preventing liver injury.
[An unrecognized neonatal emergency: extensive hematoma of the scalp. 5 cases].

BACKGROUND Subgaleal hemorrhage results from a pericranial effusion of blood subsequent to neonatal trauma. This exceptional situation compared with other pericranial effusion conditions in the neonate may be life-threatening. CASE REPORTS We report the obstetrical and neonatal data in 5 cases of subgaleal hemorrhage observed in our unit over an 8-year 8-month period. We detail one particularly demonstrative case which illustrates the potentially serious course of certain clinical presentations. DISCUSSION Subgaleal hemorrhage is a clinical diagnosis. Signs of hemorrhagic shock are associated with hemostasis disorders in the more severe forms of the condition. The main risk factor is instrumental delivery with suction. Careful monitoring is required.
Correlation between personality type and vocal pathology: A nonrandomized case control study

In this study we have made an attempt to find out if there is any correlation with type of personality (type A or B) and incidence of vocal pathology, subsequent to a tendency of vocal abuse. We also noted the loudness of speech and rate of speech for both personality types and compared these parameters for each personality type.
Match Quality, New Information, and Marital Dissolution

This article investigates the role of surprises in marital dissolution. Surprises consists of changes in the predicted earning capacity of either spouse. Data from the National Longitudinal Study of the High School Class of 1972 is used. We find that an unexpected increase in the husband's earning capacity reduces the divorce hazard, while an unexpected increase in the wife's earning capacity raises the divorce hazard. Couples sort into marriage according to characteristics that are likely to enhance the stability of the marriage. The divorce hazard is initially increasing with the duration of marriage, and the presence of children and high levels of property stabilizes the marriage.
Single layer printed monopole antenna for dual ISM-band operation

The ability of a single layer strip fed printed monopole, which has a serial-slot and an end-stepped feed-strip, to operate at dual Industrial, Scientific, and Medical-band (2.4 and 5.8 GHz bands) is demonstrated. This antenna combines omni-directional and broad bandwidth in an easy to fabricate structure. Experimental results indicate that the VSWR 2:1 bandwidths achieved were 8.2% and 18.2% at 2.45 GHz and 5.5 GHz. Effects of varying the serial-slot dimensions and the ground-plane size on the antenna performance are also described.
Return to work after occupational injury. Family physicians' perspectives on soft-tissue injuries.

OBJECTIVE To document physicians' views about facilitating factors for and barriers to their helping workers recover after occupational soft-tissue injuries and to ascertain physicians' knowledge and attitudinal barriers to their involvement in return to work. DESIGN Faxed survey. SETTING Manitoba family practices and emergency departments. PARTICIPANTS General practitioners, family physicians, and emergency physicians regularly caring for injured workers. MAIN OUTCOME MEASURES Physicians' ranking of facilitating factors and barriers, changes to help their involvement in return to work, and their attitudes and knowledge about return to work. RESULTS Respondents and nonrespondents were demographically similar, 232 physicians (51.3%) responded. Respondents believed the main facilitating factors were physicians' ability to explain the nature and prognosis of injuries to workers (69%) and the willingness of workplaces to accommodate injured workers (26%). The main barriers were workers' misunderstandings and fears about their injuries (70.7%) and non-supportive supervisors and co-workers (20.8%). The most frequently requested change was better workplace job accommodation (48%). Most physicians agreed they had a role in planning return to work and were aware of the effect of job satisfaction, psychosocial elements, and work-related factors. Despite supporting evidence, only one third of physicians stated they would say "try to continue usual activities" to patients with occupational low back pain. CONCLUSION Most physicians seemed aware of their role in return to work and the effect of occupational factors, but their advice on activity after injury differed from that in practice guidelines.
Ca2+ microdomains near plasma membrane Ca2+ channels: impact on cell function

In eukaryotic cells, a rise in cytoplasmic Ca2+ can activate a plethora of responses that operate on time scales ranging from milliseconds to days. Inherent to the use of a promiscuous signal like Ca2+ is the problem of specificity: how can Ca2+ activate some responses but not others? We now know that the spatial profile of the Ca2+ signal is important Ca2+ does not simply rise uniformly throughout the cytoplasm upon stimulation but can reach very high levels locally, creating spatial gradients. The most fundamental local Ca2+ signal is the Ca2+ microdomain that develops rapidly near open plasmalemmal Ca2+ channels like voltage‐gated L‐type (Cav1.2) and store‐operated CRAC channels. Recent work has revealed that Ca2+ microdomains arising from these channels are remarkably versatile in triggering a range of responses that differ enormously in both temporal and spatial profile. Here, I delineate basic features of Ca2+ microdomains and then describe how these highly local signals are used by Ca2+‐permeable channels to drive cellular responses.
High proportion of unrelated HIV-1 intersubtype recombinants in the Mbeya region of southwest Tanzania

Background In Mbeya, a rural region of southwest Tanzania, HIV-1 subtypes A, C and D have been co-circulating since the early 1990s. Objective To define to what extent the co-existence of subtypes has led to recombinant HIV-1 strains and whether there is evidence for epidemic spread of any circulating recombinant form. Methods Nine HIV-1-seropositive young adults from Mbeya Town with no evident high-risk behaviour contributed peripheral blood mononuclear cells for this study. Nine virtually full-length-genome-sequences were amplified from this DNA and phylogenetically analysed. Results Out of the nine samples, two were subtype A (22%), two were subtype C (22%) and five were recombinants (56%): four A/C recombinants and one C/D recombinant. None of the recombinants were related to each other; all of them had different mosaic structures. Most of the genome in the recombinants was subtype C. Conclusion A high proportion of unrelated intersubtype recombinants, none of them apparently spreading in the population, may be present in southwest Tanzania.
Quips and Quotes from Old Governors to New

Keep your agenda short. You'll only have time to build the necessary coalitions around three or four major priorities. The governor is like a conductor; you get the players, shake hands and start playing. The governorship is a position of leadership: assert it. You cannot be a leader without being a manager. Negotiation with the staff to share goals and to establish definite benchmarks is essential. There's no such thing as a new idea. Be willing to copy, borrow, and freshen up the old ideas. I'm a strong advocate of planning, but you can't sit around and wait for the planning process to tell you what to do. Use the 20-year rule: what will the state look like 20 years out? The governorship has tremendous power. You'll want to ask yourself "Have I with this power made a real difference in the lives of the people? "
Two Zinc Uptake Systems Contribute to the Full Virulence of Listeria monocytogenes during Growth In Vitro and In Vivo

ABSTRACT We report here the identification and characterization of two zinc uptake systems, ZurAM and ZinABC, in the intracellular pathogen Listeria monocytogenes. Transcription of both operons was zinc responsive and regulated by the zinc-sensing repressor Zur. Deletion of either zurAM or zinA had no detectable effect on growth in defined media, but a double zurAM zinA mutant was unable to grow in the absence of zinc supplementation. Deletion of zinA had no detectable effect on intracellular growth in HeLa epithelial cells. In contrast, growth of the zurAM mutant was significantly impaired in these cells, indicating the importance of the ZurAM system during intracellular growth. Notably, the deletion of both zinA and zurAM severely attenuated intracellular growth, with the double mutant being defective in actin-based motility and unable to spread from cell to cell. Deletion of either zurAM or zinA had a significant effect on virulence in an oral mouse model, indicating that both zinc uptake systems are important in vivo and establishing the importance of zinc acquisition during infection by L. monocytogenes. The presence of two zinc uptake systems may offer a mechanism by which L. monocytogenes can respond to zinc deficiency within a variety of environments and during different stages of infection, with each system making distinct contributions under different stress conditions.
The Single-Dose Pharmacokinetics of NWP06, a Novel Extended-Release Methylphenidate Oral Suspension

Abstract Objective: To determine the single-dose pharmacokinetics of 60 mg NWP06, a novel extended-release (ER) liquid formulation of methylphenidate (MPH) compared with 30 mg immediate-release (IR) liquid MPH, dosed at Hours 0 and 6, in adults. Methods: After institutional review board approval, 30 healthy subjects aged 18 to 68 years were enrolled in this open-label, crossover study and randomly assigned to receive NWP06/IR MPH after an overnight fast. Blood samples were collected prior to dose at Hour 0 and at post-dose hours 0.5, 1, 1.33, 1.67, 2, 2.5, 3, 4, 5, 6, 6.5, 7, 7.33, 7.67, 8, 8.5, 9, 10, 12, 14, 16, 24, and 36. Plasma concentrations of d- and l-MPH were determined and pharmacokinetic parameters were calculated. Safety assessments included vital signs, electrocardiogram, laboratory evaluations, adverse event (AE) collection, and suicidality assessment. Results: Twenty-eight subjects completed the study. The AUC0-∞ of d-MPH for NWP06 and IR MPH were 143.65 and 153.31 ng-hr/mL, respectively. The peak plasma concentration, Cmax (ng/mL), was 13.61 for NWP06 and 20.94 for IR MPH. The half-life of NWP06 was 5.65 hours and Tmax was 5 hours. For IR MPH, the half-life was 3.74 hours and Tmax was 7.33 hours. Vital sign changes were in the expected range for MPH and there were no clinically significant laboratory or ECG changes. The most common AEs reported were headache, dizziness, palpitations, nausea, and nervousness. Conclusions: A single dose of 60 mg NWP06 is equally bioavailable to two 30-mg doses of IR MPH. NWP06 has a lower peak concentration than IR MPH. Both study treatments were well tolerated, as all AEs were rated as mild in this healthy adult population.
A new version of printed Sierpinski multiband fractal antenna

A new version of printed fractal Sierpinski antenna is described in this paper, which is composed of several Sierpinski units. Besides having the multiband behavior, the new antenna possesses a beautiful, symmetrical profile and hence it can be used as ornament on a handset or a laptop. An approach of coaxial feeding has been adopted in the proposed antenna.
Transversus Abdominis Plane Block: A Systematic Review

Ultrasound guidance has led a surge of interest in transversus abdominis plane (TAP) block for postoperative analgesia following abdominal surgery. Despite or because of the numerous descriptive applications and techniques that have recently populated the literature, results of comparative studies for TAP block have been inconsistent. This systematic review pragmatically addresses many unanswered questions, specifically the following: what are the effects of surgical procedure, block dose, block technique, and block timing on TAP block analgesia? Eighteen intermediate- to good-quality randomized trials that included diverse surgical procedures were identified. Improved analgesia was noted in patients undergoing laparotomy for colorectal surgery, laparoscopic cholecystectomy, and open and laparoscopic appendectomy. There was a trend toward superior analgesic outcomes when 15 mL of local anesthetic or more was used per side compared with lesser volumes. All 5 trials investigating TAP block performed in the triangle of Petit and 7 of 12 trials performed along the midaxillary line demonstrated some analgesic advantages. Eight of 9 trials using preincisional TAP block and 4 of 9 with postincisional block revealed better analgesic outcomes. Although the majority of trials reviewed suggest superior early pain control, we were unable to definitively identify the surgical procedures, dosing, techniques, and timing that provide optimal analgesia following TAP block. This review suggests that our understanding of the TAP block and its role in contemporary practice remains limited.
The New Antimicrobial Peptide SpHyastatin from the Mud Crab Scylla paramamosain with Multiple Antimicrobial Mechanisms and High Effect on Bacterial Infection

SpHyastatin was first identified as a new cationic antimicrobial peptide in hemocytes of the mud crab Scylla paramamosain. Based on the amino acid sequences deduced, it was predicted that this peptide was composed of two different functional domains, a proline-rich domain (PRD) and a cysteine-rich domain (CRD). The recombinant product of SpHyastatin displayed potent antimicrobial activities against the human pathogen Staphylococcus aureus and the aquatic animal pathogens Aeromonas hydrophila and Pseudomonas fluorescens. Compared with the CRD of SpHyastatin, the PRD presented better antimicrobial and chitin binding activities, but both regions were essential for allowing SpHyastatin complete antimicrobial activity. The binding properties of SpHyastatin to different microbial surface molecules suggested that this might be an initial and crucial step for performing its antimicrobial activities. Evaluated using propidium iodide uptake assays and scanning electron microscopy images, the antimicrobial mechanism of SpHyastatin was found to be prone to disrupt cell membrane integrity. Interestingly, SpHyastatin exerted its role specifically on the surface of S. aureus and Pichia pastoris whereas it directly killed P. fluorescens through simultaneous targeting the membrane and the cytoplasm, indicating that SpHyastatin could use different antimicrobial mechanisms to kill different species of microbes. As expected, the recombinant SpHyastatin increased the survival rate of crabs challenged with Vibrio parahaemolyticus. In addition, SpHyastatin could modulate some V. parahaemolyticus-responsive genes in S. paramamosain.
Analysis of Metabolic Remodeling in Compensated Left Ventricular Hypertrophy and Heart Failure

Background—Congestive heart failure (CHF) is associated with a change in cardiac energy metabolism. However, the mechanism by which this change is induced and causes the progression of CHF is unclear. Methods and Results—We analyzed the cardiac energy metabolism of Dahl salt-sensitive rats fed a high-salt diet, which showed a distinct transition from compensated left ventricular hypertrophy to CHF. Glucose uptake increased at the left ventricular hypertrophy stage, and glucose uptake further increased and fatty acid uptake decreased at the CHF stage. The gene expression related to glycolysis, fatty acid oxidation, and mitochondrial function was preserved at the left ventricular hypertrophy stage but decreased at the CHF stage and was associated with decreases in levels of transcriptional regulators. In a comprehensive metabolome analysis, the pentose phosphate pathway that regulates the cellular redox state was found to be activated at the CHF stage. Dichloroacetate (DCA), a compound known to enhance glucose oxidation, increased energy reserves and glucose uptake. DCA improved cardiac function and the survival of the animals. DCA activated the pentose phosphate pathway in the rat heart. DCA activated the pentose phosphate pathway, decreased oxidative stress, and prevented cell death of cultured cardiomyocytes. Conclusions—Left ventricular hypertrophy or CHF is associated with a distinct change in the metabolic profile of the heart. DCA attenuated the transition associated with increased energy reserves, activation of the pentose phosphate pathway, and reduced oxidative stress.
Social marketers playing to win? Experiential value creation in social marketing mobile games

The rapid change of technological trends in the marketplace has increased the difficulty for social marketers to reach consumers using traditional marketing channels (Della et al., 2008). Traditionally, social marketing interventions have typically used more conventional supporting products and services such as water counters for water conservation or condoms for sex safety. However, recently social marketers are witnessing the diminishing effectiveness of more traditional social products and services in encouraging the uptake and maintenance of behaviour. In light of the technological trends in the marketplace and diminishing effect of previous social products and services (Lefebvre, 2009), social marketers have been encouraged to look to alternate means of delivering valuable offerings.
Crenarchaeal heterotrophy in salt marsh sediments

Mesophilic Crenarchaeota (also known as Thaumarchaeota) are ubiquitous and abundant in marine habitats. However, very little is known about their metabolic function in situ. In this study, salt marsh sediments from New Jersey were screened via stable isotope probing (SIP) for heterotrophy by amending with a single C-labeled compound (acetate, glycine or urea) or a complex C-biopolymer (lipids, proteins or growth medium (ISOGRO)). SIP incubations were done at two substrate concentrations (30–150 lM; 2–10 mg ml ), and C-labeled DNA was analyzed by terminal restriction fragment length polymorphism (TRFLP) analysis of 16S rRNA genes. To test for autotrophy, an amendment with C-bicarbonate was also performed. Our SIP analyses indicate salt marsh crenarchaea are heterotrophic, double within 2–3 days and often compete with heterotrophic bacteria for the same organic substrates. A clone library of C-amplicons was screened to find matches to the C-TRFLP peaks, with seven members of the Miscellaneous Crenarchaeal Group and seven members from the Marine Group 1.a Crenarchaeota being discerned. Some of these crenarchaea displayed a preference for particular carbon sources, whereas others incorporated nearly every C-substrate provided. The data suggest salt marshes may be an excellent model system for studying crenarchaeal metabolic capabilities and can provide information on the competition between crenarchaea and other microbial groups to improve our understanding of microbial ecology. The ISME Journal (2014) 8, 1534–1543; doi:10.1038/ismej.2014. 15; published online 20 February 2014 Subject Category: Microbial ecology and functional diversity of natural habitats
Rich punctuations prediction using large-scale deep learning

Punctuation plays an important role in language processing. However, automatic speech recognition systems only output plain word sequences. It is then of interest to predict punctuations on plain word sequences. Previous works have focused on using lexical features or prosodic cues captured from small corpus to predict simple punctuations. Compared with simple punctuations, rich punctuations provide more meaningful information and are more difficult to predict. In this paper, a multi-view LSTM model is proposed to predict rich punctuations on large-scale corpora. In particular, predictions on both in-domain and out-of-domain datasets are investigated. Experiments showed that LSTM can significantly outperform the traditional CRF-based model. Moreover, large-scale corpora are proved to bring large progress, and introducing POS tags and Chunking information in a multi-view structure improves performance of LSTM model on small corpus.
Maximum power‐point tracking control for wind farms

This paper presents a data-driven adaptive scheme to adjust the control settings of each wind turbine in a wind farm such that an increase in the total power production of the wind farm is achieved. This is carried out by taking into account the interaction between the turbines through wake effects. The optimization scheme is designed in such a way that it yields fast convergence so that it can adapt to changing wind conditions quickly. The scheme has a distributed architecture in which each wind turbine adapts its control settings through gradient-based optimization, using information that it receives from neighbouring turbines. The novel control method is tested in a simulation of the Princess Amalia Wind Park. It is shown that the distributed gradient-based approach performs the optimization in a more time-efficient manner compared with an existing data-driven wind farm power optimization method that uses a game theoretic approach. Copyright © 2014 John Wiley & Sons, Ltd.