Miracle-dz/UniFAR-FTUs huggingface dataset:
A phase I/II, open-label, randomised study of nintedanib plus mFOLFOX6 versus bevacizumab plus mFOLFOX6 in first-line metastatic colorectal cancer patients.

BACKGROUND This randomised, open-label, phase I/II study evaluated the efficacy and safety of nintedanib, an oral, triple angiokinase inhibitor, combined with chemotherapy, relative to bevacizumab plus chemotherapy as first-line therapy in patients with metastatic colorectal cancer (mCRC). PATIENTS AND METHODS Patients with histologically confirmed mCRC (adenocarcinoma), an Eastern Cooperative Oncology Group performance status ≤ 2 and adequate organ function were included. Patients were randomised 2:1 to receive nintedanib 150 mg or 200 mg b.i. d. plus mFOLFOX6 (oxaliplatin 85 mg/m(2), l-leucovorin 200 mg/m(2) or d,l-leucovorin 400 mg/m(2), 5-fluoruracil bolus 400 mg/m(2) followed by 2400 mg/m(2), every 2 weeks) or bevacizumab (5 mg/kg every 2 weeks) plus mFOLFOX6. During phase I, patients underwent a 3 + 3 dose-escalation schema to determine the maximum tolerated dose (MTD) of nintedanib in combination with mFOLFOX6. The primary end point was progression-free survival (PFS) rate at 9 months. Objective response (OR) was a secondary end point. RESULTS The nintedanib recommended phase II dose was 200 mg b.i. d. plus mFOLFOX6 based on safety data from phase I (n = 12). Of 128 patients randomised in the phase II part, 126 received treatment (nintedanib plus mFOLFOX6, n = 85; bevacizumab plus mFOLFOX6, n = 41). PFS at 9 months was 62.1% with nintedanib and 70.2% with bevacizumab [difference: -8.1% (95% confidence interval -27.8 to 11.5)]. Confirmed ORs were recorded in 63.5% and 56.1% of patients in the nintedanib and bevacizumab groups, respectively. The incidence of adverse events (AEs) considered related to treatment was 98.8% with nintedanib and 97.6% with bevacizumab; the incidence of serious AEs was 37.6% with nintedanib and 53.7% with bevacizumab. The pharmacokinetics of nintedanib and the components of mFOLFOX6 were unaffected by their combination. CONCLUSIONS Nintedanib in combination with mFOLFOX6 showed efficacy as first-line therapy in patients with mCRC with a manageable safety profile and further studies in this population are warranted.
Spatio-Temporally Consistent View Synthesis From Video-Plus-Depth Data With Global Optimization

We propose a novel algorithm to generate a virtual-view video from a video-plus-depth sequence. The proposed method enforces the spatial and temporal consistency in the disocclusion regions by formulating the problem as an energy minimization problem in a Markov random field (MRF) framework. At the system level, we first recover the depth images and the motion vector maps after the image warping with the preprocessed depth map. Then, we formulate the energy function for the MRF with additional shift variables for each node. To reduce the high computational complexity of applying belief propagation (BP) to this problem, we present a multilevel BPs by using BP with smaller numbers of label candidates for each level. Finally, the Poisson image reconstruction is applied to improve the color consistency along the boundary of the disocclusion region in the synthesized image. Experimental results demonstrate the performance of the proposed method on several publicly available datasets.
Millimeter-wave beamforming circuits in SiGe BiCMOS

Integrated millimeter-wave 2 bit and 3 bit phase shifters and 4 channel beamforming network are presented in this paper. The 2 bit phase shifter exhibits 4° RMS phase error and a RMS gain error < 1 dB. In the 55–67 GHz range, the 3 bit phase shifter shows RMS phase error < 7° and a RMS gain error < 1 dB. The 4 channel beamforming network consists of four 2 bit RF phase shifter and a fully differential passive power distribution network. Between the 4 channels, the beamforming network exhibits less than 4° and 0.6 dB RMS phase and amplitude mismatch, respectively. The beamforming chip and the phase shifters are fabricated in SiGe BiCMOS technology. The 2 bit and 3 bit phase shifters draws 7 mA and 10 mA respectively from a 3.3 V supply. The circuits are well suited for highly integrated beamforming millimeter-wave transceivers.
The Initial Qualifications, Induction and In‐Service Needs of Education Social Workers in Wales1

This paper presents an analytical evaluation of the initial entry qualifications, induction and in‐service requirements of education welfare officers (EWO)/education social workers (ESW) in Wales. These data were obtained from a sponsored research project funded by the Welsh Assembly Government conducted on a pan‐Wales basis. The findings indicate that only five local education authorities (LEAs) in Wales presently require social work qualifications for entry to the service. A majority of staff in the remaining LEAs tend to hold low level qualifications. Whilst induction practices vary between LEAs, better and improved practice is beginning to emerge. Similarly, the in‐service needs of ESW/EWS staff are not normally analysed systematically. Therefore, a variety of different approaches are used within LEAs to meet the in‐service needs of education welfare/social work staff. Some examples of good practice are postulated. Recommendations to improve the induction, initial training and in‐service requirements of staff in Wales are made alongside the need for further research.
Localised calcium release events in cells from the muscle of guinea‐pig gastric fundus

After enzymatic dispersion of the muscle of the guinea‐pig gastric fundus, single elongated cells were observed which differed from archetypal smooth muscle cells due to their knurled, tuberose or otherwise irregular surface morphology. These, but not archetypal smooth muscle cells, consistently displayed spontaneous localized (i.e. non‐propagating) intracellular calcium ([Ca2+]i) release events. Such calcium events were novel in their magnitude and kinetic profiles. They included short transient events, plateau events and events which coalesced spatially or temporally (compound events). Quantitative analysis of the events with an automatic detection programme showed that their spatio‐temporal characteristics (full width and full duration at half‐maximum amplitude) were approximately exponentially distributed. Their amplitude distribution suggested the presence of two release modes. Carbachol application caused an initial cell‐wide calcium transient followed by an increase in localized calcium release events. Pharmacological analysis suggested that localized calcium release was largely dependent on external calcium entry acting on both inositol trisphosphate receptors (IP3Rs) and ryanodine receptors (RyRs) to release stored calcium. Nominally calcium‐free external solution immediately and reversibly abolished all localized calcium release without blocking the initial transient calcium release response to carbachol. This was inhibited by 2‐APB (100 μm), ryanodine (10 or 50 μm) or U‐73122 (1 μm). 2‐APB (100 μm), xestospongin C (XeC, 10 μm) or U‐73122 (1 μm) blocked both spontaneous localized calcium release and localized release stimulated by 10 μm carbachol. Ryanodine (50 μm) also inhibited spontaneous release, but enhanced localized release in response to carbachol. This study represents the first characterization of localized calcium release events in cells from the gastric fundus.
Generation of Amylosucrase Variants That Terminate Catalysis of Acceptor Elongation at the Di- or Trisaccharide Stage

ABSTRACT An amylosucrase gene was subjected to high-rate segmental random mutagenesis, which was directed toward a segment encoding amino acids that influence the interaction with substrate molecules in subsites −1 to +3. A screen was used to identify enzyme variants with compromised glucan chain elongation. With an average mutation rate of about one mutation per targeted codon, a considerable fraction (82%) of the clones that retained catalytic activity were deficient in this trait. A detailed characterization of selected variants revealed that elongation terminated when chains reached lengths of only two or three glucose moieties. Sequencing showed that the amylosucrase derivatives had an average of no more than two amino acid substitutions and suggested that predominantly exchanges of Asp394 or Gly396 were crucial for the novel properties. Structural models of the variants indicated that steric interference between the amino acids introduced at these sites and the growing oligosaccharide chain are mainly responsible for the limitation of glucosyl transfers. The variants generated may serve as biocatalysts for limited addition of glucose moieties to acceptor molecules, using sucrose as a readily available donor substrate.
The metabolism of naphthalene and 1-naphthol by houseflies and rats.

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Synergistic Antitumor Activity of Sorafenib in Combination with Epidermal Growth Factor Receptor Inhibitors in Colorectal and Lung Cancer Cells

Purpose: Cancer cell survival, invasion, and metastasis depend on cancer cell proliferation and on tumor-induced angiogenesis. We evaluated the efficacy of the combination of sorafenib and erlotinib or cetuximab. Experimental Design: Sorafenib, erlotinib, and cetuximab, alone or in combination, were tested in vitro in a panel of non–small cell lung cancer (NSCLC) and colorectal cancer cell lines and in vivo in H1299 tumor xenografts. Results: Epidermal growth factor receptor (EGFR) ligand mRNAs were expressed in all NSCLC and colorectal cancer cell lines with variable levels ranging from 0.4- to 8.1-fold as compared with GEO colorectal cancer cells. Lung cancer cells had the highest levels of vascular endothelial growth factors (VEGF) A, B, and C, and of VEGF receptors as compared with colorectal cancer cells. Combined treatments of sorafenib with erlotinib or cetuximab produced combination index values between 0.02 and 0.5, suggesting a significant synergistic activity to inhibit soft agar colony formation in all cancer cell lines, which was accompanied by a marked blockade in mitogen-activated protein kinase and AKT signals. The in vitro migration of H1299 cells, which expressed high levels of both VEGF ligands and receptors, was inhibited by treatment with sorafenib, and this effect was significantly increased by the combination with anti-EGFR drugs. In nude mice bearing established human H1299 xenografts, treatment with the combination of sorafenib and erlotinib or cetuximab caused a significant tumor growth delay resulting in 70 to 90 days increase in mice median overall survival as compared with single-agent sorafenib treatment. Conclusions: Combination treatment with sorafenib and erlotinib or cetuximab has synergistic antitumor effects in human colorectal and lung cancer cells. Clin Cancer Res; 16(20); 4990–5001. ©2010 AACR.
Constructing a Distributed AUV Network for Underwater Plume-Tracking Operations

In recent years, there has been significant concern about the impacts of offshore oil spill plumes and harmful algal blooms on the coastal ocean environment and biology, as well as on the human populations adjacent to these coastal regions. Thus, it has become increasingly important to determine the 3D extent of these ocean features (“plumes”) and how they evolve over time. The ocean environment is largely inaccessible to sensing directly by humans, motivating the need for robots to intelligently sense the ocean for us. In this paper, we propose the use of an autonomous underwater vehicle (AUV) network to track and predict plume shape and motion, discussing solutions to the challenges of spatiotemporal data aliasing (coverage versus resolution), underwater communication, AUV autonomy, data fusion, and coordination of multiple AUVs. A plume simulation is also developed here as the first step toward implementing behaviors for autonomous, adaptive plume tracking with AUVs, modeling a plume as a sum of Fourier orders and examining the resulting errors. This is then extended to include plume forecasting based on time variations, and future improvements and implementation are discussed.
Maintaining change programmes for offenders: some suggestions for practice

Abstract Despite the widespread acceptance that follow-up or maintenance sessions are an important part of the change process for those who have completed offender rehabilitation programmes, there have been few attempts to articulate the basis upon which such sessions might be developed. This paper reviews the current theoretical and empirical literature relating to maintenance programmes, concluding that whilst there are a number of theories which might be relevant to the design of effective maintenance programmes, there is almost no empirical basis from which to make any assessment of their likely value or effectiveness.
Operationalizing Family Resilience: A Methodological Strategy

This article explores several research design and analysis strategies for examining family resilience, and presents a strategy argued to reflect the process-oriented nature of this construct. We advocate a quantitative, longitudinal strategy, sensitive to both the context of a family and the unique stressor being examined. Our strategy was tested with longitudinal data, assessing transitions relating to the birth of a first child. Challenges connected with this model are presented, as well as clinical implications and directions for future research. Identifying differing resilience trajectories which families exhibit in response to stress may aid in identifying factors instrumental in shaping those trajectories.
Swab-wash method for quantitation of cutaneous microflora

We describe a comparison of the scrub-wash method of Williamson and Kligman and a swab-wash method for the enumeration of cutaneous microflora. The swab-wash method provides a less traumatic alternative to the scrub-wash method and can be used to sample the cutaneous microflora of premature neonates.
Perceived Slant as a Function of Stimulus Contour and Vertical Dimension

24 Os judged the slants represented by nine trapezoids presented monocularly and binocularly, with fixed head under reduced viewing conditions. The trapezoids were the frontal-parallel plane projections of rectangles with the dimensions, 12 in. by 6 in. , 10 in. by 5 in. , and 8 in. by 4 in. , each slanted 30°, 45° and 60°, but with their heights increased to 12 in. , 10 in. and 8 in. , respectively, and the other contour dimensions increased in proportion. All forms were displayed in the frontal-parallel plane only. The greatest variance in the slant judgments was associated with variation in contour. Decrease in stimulus height tended to be associated with increase in judged slant. Monocular and binocular judgments did not differ significantly. There were no significant interactions. The results were interpreted as supporting the contour perspective theory of monocular slant.
SUBCATEGORIES OF POSITIVE EMOTION

Positive emotions are indispensable in our lives. However, their structure has not yet been clarified, and the majority of previous studies have simply assumed a single category of positive emotions. Several recent psychological and neuroscientific findings suggest the existence of subcategories of positive emotion. Similarly, the psychological functions of positive emotions can be more deeply understood when they are subcategorized. We conclude that subcategorizing positive emotions is a promising avenue for future research on emotion.
Constructivist Coaching and Expertise Development as Action Research

This case study assessed the efficacy of a constructivist development approach and subsequent action research methodology during sport-science support to an international shooting team (n=14) over a two-year period. Specific analysis focused on the benefits of a coach-focussed program to integrate the pluralism associated with the development of sporting expertise. The broadest possible range of methods and tools were utilised to ensure a multi-level awareness of change was provided This required monitoring and controlling change in organisational, team, relational and individual behaviour. Findings revealed that an emergenic, iterative, ecological and meta-level process of coaching and sport-science support was conducive to the needs of this particular squad due to the nesting and multi-dimensional issues related to performance behaviours within intra-personal, inter-personal, group and social domains, and the rich-interconnectedness associated with the relevant domains of expertise. Furthermore, the constructivist, coach-focussed program within the project was endorsed.
Maternal attachment feelings mediate between maternal reports of depression, infant social–emotional development, and parenting stress

Objective: The current study examined whether having a positive maternal postpartum depression screening was associated with maternal report of poorer infant social–emotional development and more negative maternal report of parent–child interaction, and whether scores on a measure of maternal feelings of attachment influenced this relationship. Methods: Two hundred and thirty-two first-time mothers and their infants were assessed using self-reporting questionnaires when infants were 2 and 6 months of age. At 2 months, mothers were screened for postpartum depression and their feelings of attachment to their infants were also measured. At 6 months, mothers reported on infant social–emotional development and the parent–child interaction. Results: Findings revealed an association between having a positive screening for maternal depression at 2 months, and reports of both at-risk infant social–emotional development and parent–child dysfunctional interaction at 6 months. Further analyses indicated that maternal feelings of attachment mediated rather than moderated these relationships. Conclusions: These results suggest that the association of maternal postpartum depression with later child outcomes may be the result of the negative effects of maternal depression on maternal feelings of attachment to her infant.
Graphical Model of Cardiac Electromagnetic Source

Instead of the human torso model in study of inverse solutions of sources estimation, a graphical model is developed, which is constructed by the equivalent current dipole (ECD) or equivalent magnetic dipole (EMD) source model and MCG measurements based on the sub-sectional approximate principle of the magnetic field zero value curve. The simulations results available indicate that a current multi-dipole graphical model effectively describe the magnetic field between detected MCG and cardiac current sources.
Diversifying and correlational selection on behavior toward conspecific and heterospecific competitors in brook stickleback (Culaea inconstans)

Behaviors toward heterospecifics and conspecifics may be correlated because of shared mechanisms of expression in both social contexts (nonadaptive covariation) or because correlational selection favors adaptive covariation. We evaluated these hypotheses by comparing behavior toward conspecifics and heterospecifics in brook stickleback (Culaea inconstans) from three populations sympatric with and three allopatric from a competitor, the ninespine stickleback (Pungitius pungitius). Behavioral traits were classified into three multivariate components: overt aggression, sociability, and activity. The correlation of behavior between social contexts for both overt aggression and activity varied among populations in a way unrelated to sympatry with ninespine stickleback, while mean aggression was reduced in sympatry. Correlations in allopatric populations suggest that overt aggression and activity may genetically covary between social contexts for nonadaptive reasons. Sociability was rarely correlated in allopatry but was consistently correlated in sympatry despite reduced mean sociability, suggesting that correlational selection may favor a sociability syndrome in brook stickleback when they coexist with ninespine stickleback. Thus, interspecific competition may impose diversifying selection on behavior among populations, although the causes of correlated behavior toward conspecifics and heterospecifics and whether it can evolve in one social context independent of the other may depend on the type of behavior.
Modeling TB-HIV Syndemic and Treatment

Tuberculosis (TB) and human immunodeficiency virus (HIV) can be considered a deadly human syndemic. In this paper, we formulate a model for TB and HIV transmission dynamics. The model considers both TB and acquired immune deficiency syndrome (AIDS) treatment for individuals with only one of the two infectious diseases or both. The basic reproduction number and equilibrium points are determined and stability is analyzed. Through simulations, we show that TB treatment for individuals with only TB infection reduces the number of individuals that become coinfected with TB and HIV/AIDS and reduces the diseases (TB and AIDS) induced deaths. Analogously, the treatment of individuals with only AIDS also reduces the number of coinfected individuals. Further, TB treatment for coinfected individuals in the active and latent stage of TB disease implies a decrease of the number of individuals that passes from HIV-positive to AIDS.
Coping with School-Related Stress and Family Stress in Healthy and Clinically Referred Adolescents

This study compares stress perception and coping style in 77 early and late adolescents differing in psychological health. Coping with two normative, age-specific stressors, namely, school-related stressors, and conflicts with parents was investigated via the Coping Process Interview, which assesses coping immediately after an event has happened. Results obtained from the interviews were validated by the results of standardized questionnaires assessing stress perception and coping style in dealing with school-related stress and family stress. Both stressors were not perceived as structurally similar events. Differences were obtained with respect to the appraisal of the stressor, causal attribution, the amount of thoughts, feelings, and actions in order to cope with these stressors, but not in achieved effects and reappraisal. In addition, differences between clinically referred and nonconspicuous adolescents emerged with respect to stress perception and coping style. Clinically referred adolescents, independent from diagnosis, experienced higher levels of school-related stress and family stress and also exhibited a more dysfunctional coping style when dealing with both types of stressors.