Miracle-dz/UniFAR-FTUs huggingface dataset:
Extreme Neutrophilie bei der Katze – Ätiologie und Prognose

Zusammenfassung Ziel der retrospektiven Studie war, Ätiologie und prognostische Faktoren einer extremen Neutrophilie bei Katzen zu untersuchen. Methoden: Die Auswertung erstreckte sich auf die Krankenakten von 5 Jahren (Januar 2008 bis Dezember 2013). Einschlusskriterium war eine Neutrophilenzahl von > 40 x 109/l. Es erfolgte eine Einteilung in die vier Gruppen „Entzündung”, „Neoplasie”, „immunvermittelte Erkrankung und „unbekannte Ätiologie”. Ausgewertet wurden die Parameter Vorstellungsgrund, Körperinnentemperatur, Hospitalisierung, Hospitalisierungszeit, Überleben, Linksverschiebung und Toxizität neutrophiler Granulozyten. Ergebnisse: 28/5185 Katzen (0,5%) zeigten eine extreme Neutophilie mit einer medianen Neutrophilenzahl von 48,5 x 109/l (40,0–76,0 x 109/l). Entzündliche Prozesse waren mit 16/28 Fällen (57%) die häufigste Ätiologie, wobei die Peritonitis (5/15 Katzen, 31%) dominierte. In der Gruppe Neoplasie (9/28 Katzen, 32%) lag am häufigsten eine intestinale Neoplasie mit sekundärer Peritonitis vor (4/9 Katzen, 44%). Unbekannte (2/28 Katzen, 7%) und immunvermittelte Erkrankungen (1/28 Katzen, 3,6%) kamen seltener vor. Die häufigsten Vorstellungsgründe waren Mattigkeit, Inappetenz, Fieber und gastrointestinale Symptome. Die Körperinnentemperatur variierte zwischen 33,9 °C und 40,2 °C, wobei 2/24 Katzen (8%) eine Hyperthermie (> 39,3 °C) und 5/24 Katzen (21%) eine Hypothermie (< 38,0 °C) aufwiesen. 21/28 Katzen (75%) wurden über median 5,5 Tage (1–30 Tage) hospitalisiert. Von 24/28 Katzen lag ein manuell angefertigtes Differenzialzellbild vor, wobei in 23/24 Fällen (96%) eine Linksverschiebung und in 21/24 (88%) eine Toxizität neutrophiler Granulozyten nachgewiesen wurde. Der Anteil überlebender Katzen betrug ca. 50% und war in der Gruppe „Neoplasie” geringer als in der Gruppe „Entzündung” (22% vs. 56%, p < 0,0001). Schlussfolgerung: Eine extreme Neutrophilie ist bei der Katze selten. Sie entsteht häufig durch fremdkörperassoziierte Peritonitiden oder rupturierte intestinale Neoplasien (insbesondere intestinales Lymphom) und zeichnet sich durch eine hohe Mortalität aus.
High resolution radar imaging based on compressed sensing and adaptive Lp norm algorithm

Radar imaging based compressive sensing (CS) is a potential way to obtain the high-resolution radar images without the constraint of Nyquist sampling rate. In this paper, we proposed a radar remote-sensing imaging approach based on compressive sensing and adaptive Lp norm algorithm. Some experiments are taken and the results indicate that an accurate reconstruction of high-resolution radar images are obtained, with fewer measurements than its counterparts, but resulting in lower normalized MSE(NMSE).
Testing electrostatic energy harvesters: A new topology for accurate characterization

Small autonomous devices using low power techniques can be supplied by energy harvesters. In this paper we focus on electrostatic energy harvesters using a variable capacitor as transducer. The capacitance, charge and voltage vary in a loop process. Many different setups are known. The aim of this paper is to show a method to characterize the harvested energy of the intrinsic harvester. Due to the very low currents in the range of nA, it is difficult to do exact measurements without influencing the harvesting process. A new improved topology is used to ensure the autonomous operation of the harvester circuit. This topology makes it possible to measure the converted energy more accurately, even if there are resistive losses in the variable capacitor. Thus we can obtain comparable results on the efficiency of the harvester itself. The amount of harvested energy can be determined easily by processing the measured values.
Economic Valuation of Tourism Destination Image

This paper develops a novel methodology for estimating the value of destination image, which incorporates two principal advantages over the methods used to date. First, it allows tourism destination image to be assessed in economic terms, so a formal cost–benefit analysis can be executed to ascertain whether or not a specific marketing action should be implemented. Second, it enables a disentangling of the economic assessment of tourist destination image in terms of destination attributes. This can be used to design marketing actions aimed at optimizing marketing efforts to enhance a destination's image.
Output Growth, Inflation and Interest Rate on Stock Return and Volatility: The Predictive Power

Using monthly data from seven mature and emerging markets and GARCH and EGARCH models, the study of Davis and Kutan (Applied Financial Economics, 13, 693-700, 2003) on inflation and output on stock returns and volatility is extended by including interest rate to compare the effect between three mature markets (US, Japan and Singapore) and four crisis experienced emerging markets (Malaysia, India, Korea and Philippines). Results reveal that economic volatility, as measured by movement in inflation, output growth, and interest rate, has weak predictor power on stock market volatility and returns. In line with the evidence reported in Davis and Kutan (2003), the findings suggest that the Fisher effect in stock returns among the seven mature and emerging markets is not supported.
Synthesis of control protocols for multi-agent systems with similar actions

In this paper we investigate supervisor synthesis for a multi-agent system whose components' alphabets are bijectively similar to each other, i.e., they are “identical” under a pre-specified one-to-one relabeling scheme. We first introduce the concept of multi-agent systems with similar actions. Then we formulate a problem of control protocol synthesis, which aims to compute a supervisor template whose instantiations (via event relabeling) associated with local components form a distributed supervisor. After that, we show that protocol synthesis is always feasible for decomposable requirements, while the existence of a protocol is undecidable for an indecomposable requirement. In the former case, algorithms are presented to compute a protocol when a multi-agent system and a decomposable requirement is given, and in the latter case a conservative requirement decomposition algorithm is provided.
Pressure dependence of magnetoresistance for Fe/Cr multilayers

The magnetoresistance (MR) in Fe/Cr magnetic multilayers (MML) has been measured under high pressure up to 2.5 GPa. It is found that the spin-dependent scattering plays an important role in the pressure dependence of MR ratio. In the present work, for [Fe(20/spl Aring/)/Cr(10 /spl Aring/)]/sub 20/ MML with antiferromagnetic (AF) state, the pressure coefficient of saturation field H/sub s/ is (1/H/sub s/)(/spl part/H/sub s///spl part/P)=3.3/spl times/10/sup -2/ GPa/sup -1/ between 0.1 and 2.5 GPa. We found that the (1/|J|)(/spl part/|J|//spl part/P) for AF-Fe/Cr MML with polycrystalline structure is opposite in sign to that with epitaxial one. For [Fe(20 /spl Aring/)/Cr(22/spl Aring/)]/sub 20/ MML with ferromagnetic (F) state, anisotropic magnetoresistance (AMR) decreases with increasing pressure. It is suggested that the anisotropy constant decreases with weakening spin-orbit interaction at high pressure. At high field, the AMR is easily suppressed by applying pressure while the giant magnetoresistance around H/sub s/ increases slightly with increasing pressure for polycrystalline Fe/Cr MML.
Dysplasia of Nonmetaplastic Gastric Mucosa: A Proposal for its Classification and its Possible Relationship to Diffuse‐Type Gastric Carcinoma

In a review of 192 gastric resections, histological changes believed to represent dysplasia of nonmetaplastic gastric epithelium were observed. This paper presents a proposal for their classification. The main feature of this dysplasia is replacement of the differentiated cells lining the glands by undifferentiated cells with varying degrees of cytological abnormalities and cellular pleomorphism, but with absence of architectural glandular derangement. The classification is justified by cytokinetic and histologic observations in experimental gastric carcinogenesis and early human gastric carcinoma. The severity of the changes is graded, first, by the extent of involvement of the gland (crypt) as measured from the proliferative zone (PZ), and, second, by the degree of cytological abnormality. It utilizes a modification of the terminology of Riddell et al. (45) for dysplasia in inflammatory bowel disease wherein the term “dysplasia” denotes intraepithelial neoplasia. The changes are classified into (a) negative for dysplasia, (b) atypical, i.e., indefinite for dysplasia, and (c) positive for dysplasia. Changes negative for dysplasia are considered regenerative and consist of enlargement and vesicular transformation of the nucleus in the cells of the PZ and adjacent part of the crypt. Atypical changes consist of equivocal lesions difficult to classify as definitely regenerative or definitely dysplastic, and are hence called indefinite for dysplasia. They consist of loss of cytoplasmic differentiation of the cells lining the glands (i.e., mucus production and parietal and chief cell differentiation) with increased nuclear-cyto-plasmic ratio and moderate cytological atypicality. Based on the extent of gland involvement, the group with atypical mucosa is subdivided into two categories—atypical, probably negative for dysplasia (AtN) and atypical, probably positive for dysplasia (AtP). Mucosa exhibiting unequivocal cytological features of neoplasia with cellular and nuclear pleomorphism is classified as positive for dysplasia (D). This is subdivided into low-grade and high-grade dysplasia, the latter representing carcinoma in situ. Glandular architecture remains undisturbed in all stages and the cells remain cuboidal, without transformation into intestinal-type cells. This type of dysplasia was found in a significantly higher number of diffuse-type carcinomas than in intestinal-type carcinomas. The previously well-recognized adenomatous or metaplastic dysplasia was significantly more prevalent in intestinal-type carcinoma than in diffuse-type. We believe that this non-metaplastic dysplasia represents a second pathway in the genesis of gastric carcinoma, possibly the diffuse type, and would thus serve as an additional indicator of individuals at risk for gastric cancer. Our findings suggest that the PZ is the site of origin of this dysplasia.
Trimethaphan is a Direct Arterial Vasodilator and an $aL‐Adrenoceptor Antagonist

In helically cut strips of dog cerebral, mesenteric, and femoral arteries contracted with prostaglandin (PG) F2α, trimethaphan (10-5-10--3 M) caused a dose-related relaxation that was not influenced by atropine, propranolol, diphenhydramine, cimetidine, aminophylline, or indomethacin. Trimethaphan-induced relaxation was greater in extracerebral than in cerebral arteries. The relaxation was greater in phenylephrine-contracted arteries than in PGF2α-contracted arteries. On the other hand, hexamethonium did not relax the arteries. Trimethaphan (10-4-10-3 M) shifted the dose-response curve for norepinephrine in mesenteric arteries to the right, but failed to influence the contractile response to 25 mM KCl. Treatment with trimethaphan (10-4-10-3 M) protected α-adrenergic receptors from persistent blockade by phenoxybenzamine. Trimethaphan (10-7-3 × 10-6 M) and hexamethonium (3 × 10-8-10-6 M) significantly attenuated the contractile response of mesenteric arteries to nicotine in a dose-dependent manner, but did not alter the response to transmural electrical stimulation. The antinicotinic potency of trimethaphan was approximately one-fourth that of hexamethonium. It is concluded that, unlike hexamethonium, trimethaphan acts directly on vascular smooth muscle to induce vasodilation, more prominently in extracerebral arteries than in cerebral arteries. In high concentrations, trimethaphan appears to possess an α-adrenergic blocking action.
Ernährung bei Krebs: geeignet zur Vorbeugung und Therapie?

Zusammenfassung Ernährung dient dem Aufbau und Erhalt des Körpers und seiner Funktionen und ist damit Grundvoraussetzung, um den Tagesablauf und die täglichen Belastungen stabil zu überstehen. Es ist deshalb naheliegend zu überlegen und zu erforschen, ob und inwieweit die Aufnahme von Nährstoffen die Krebsanfälligkeit oder die Tumortherapie beeinflussen.
Individualizing Cancer Care with Interoperable Information Systems

There are three levels of interoperable informatics that are co-occurring in the United States to link data to provide more comprehensive care to patients. One is the National Health Information Network (NHIN) that is establishing use case scenarios and standards for interoperability for patients with multiple conditions. The second is the National Cancer Institute's project that supports the enterprise work called the Cancer Bioinformatics Grid (caBIG) in linking clinical care with bioinformatics, tissue repositories, and imaging for patients with cancer. The third is in the area of translating the discoveries of biology to bedside care through the National Institutes of Health (NIH) translational research efforts to get these new biomedical and genomic discoveries in practice in multiple healthcare delivery environments. These developments are becoming global networks in the diagnosis and cure of cancer as the primary outcome. This paper describes the national efforts and the global connection to Europe through the caBIG program. The European program that is beginning to link to cancer research internationally is the National Cancer Research Institute (NCRI) in the United Kingdom. They are developing the NCRI Oncology Information Exchange (ONIX) to provide the cancer research community with the ability to share information.
Explaining Caste Differences in Private School Attendance

Using nationally representative education survey, we explore caste differences in private school attendance in India. We find lower private school attendance among the disadvantaged castes -- Scheduled Castes (SCs), Scheduled Tribes (STs), and Other Backward Castes (OBCs) -- when compared to the non-disadvantaged group (non-SC/ST/OBC). Controlling for geographical location, household and individual level factors reduces the gaps in private school attendance considerably, however the gaps remain quite large. We find that variation in parental education and household consumption expenditure explains a significant proportion of the observed gaps. For ST students, geographical location remains important in explaining the gap in private school attendance.
Comparison of different network densification alternatives from the LTE uplink point of view

This paper presents a novel comparison of different network densification alternatives from the LTE uplink point of view. The comparison is performed for the same environment considering, among other things, an advanced three-dimensional modeling of propagation and user distribution within the traffic hotspots. The obtained results indicate that various types of heterogeneous network deployments are realistic alternatives to the traditional way of deploying new macro sites. The downside of heterogeneous deployments is that the required number of new sites becomes considerably larger, which can cause problems from the backhaul availability and power supply point of view. Hence, based on these initial results, the heterogeneous deployments seem to be the most feasible for scenarios with a limited availability of new macro sites.
Adjuvant systemic therapies in women with breast cancer: an audit of clinical practice in Italy.

BACKGROUND Evidence-based guidelines, consensus conferences and experts' opinion are rarely promptly transferred to patient care. We audited prescriptions of adjuvant systemic therapies for Italian breast cancer patients and compared them with recommendations of an International Consensus Panel. PATIENTS AND METHODS Disease characteristics and adjuvant therapies for 768 breast cancer patients referred to 87 Italian centers from 16 to 23 March 2000 were evaluated for adherence to the published recommendations. RESULTS Endocrine therapy was not prescribed for 102 of 541 patients (19%) with endocrine-responsive disease and for 22 of 45 patients (49%) with unknown hormonal receptor status. Instead, endocrine therapy was prescribed for 22 of 182 patients (12%) with endocrine-unresponsive disease. Adjuvant chemotherapy was prescribed for 98% of the patients. The type of chemotherapy was the cyclophosphamide, methotrexate, 5-fluorouracil regimen for 453 of 754 (60%), while 253 of 754 (34%) received an anthracycline-based regimen. The proportion of patients with anthracyclines increased with the number of involved axillary nodes and grading, and decreased with age. Endocrine therapy was administered to 482 of 768 (63%) and was mainly represented by an antiestrogen. CONCLUSIONS Lack of adherence to evidence-based guidelines for adjuvant treatment of Italian breast cancer patients was as high as 19%. It might be wise for national health authorities to promote education on life-saving procedures, like adjuvant systemic treatments, in cancer medicine.
Bevacizumab Prevents Brain Metastases Formation in Lung Adenocarcinoma

Patients with nonsquamous non–small cell lung cancer (nsNSCLC; largely lung adenocarcinoma) are at high risk of developing brain metastases. Preclinical data suggested that anti–VEGF-A therapy may prevent the formation of nsNSCLC brain metastases. Whether non-brain metastases are also prevented, and whether bevacizumab shows a brain metastases–preventive activity in cancer patients is unknown. Data of one nsNSCLC (stage IIIB/IV, AVAiL) and two breast cancer bevacizumab trials (HER2 negative, AVADO; HER2 positive, AVEREL) were retrospectively analyzed regarding the frequency of the brain versus other organs being the site of first relapse. For animal studies, the outgrowth of PC14-PE6 lung adenocarcinoma cells to brain macrometastases in mice was measured by intravital imaging: under control IgG (25 mg/kg) treatment, or varying doses of bevacizumab (25 mg/kg, 2.5 mg/kg, 0.25 mg/kg). Brain metastases as site of first relapse were significantly less frequent in the bevacizumab arm of the AVAiL trial (HR = 0.36, P < 0.001). In AVADO and AVEREL, no significant difference was seen. In mice, bevacizumab treatment led to secondary regressions of non-brain macrometastases, but did not reduce their total incidence, and did not improve survival. In a brain-seeking nsNSCLC metastasis model, treatment with bevacizumab inhibited brain metastases formation, which resulted in improved overall survival. In summary, bevacizumab has the potential to prevent brain metastases in nsNSCLC, but no preventive activity could be detected outside the brain. These data indicate that anti–VEGF-A agents might be particularly relevant for those stage III nsNSCLC patients who are at high risk to develop future brain metastases. Mol Cancer Ther; 15(4); 702–10. ©2016 AACR.
Rice proteomics: Current status and future perspectives

Rice, the first cereal crop genome to be decoded, has attracted the attention of researchers worldwide because of its immense socio‐economic impact on human existence. With the availability of the draft genome sequence of two major types, japonica‐ and indica‐rice, “rice proteomics” has entered into the era of functional genomics. Although during the last decade an important but limited progress (mainly construction of protein datafiles) has been made in the field of rice proteomics, it is only recently that dedicated research groups have taken this challenge to systematically analyze the rice proteome at the cell (and organelle), tissue, and whole plant level. Important gains achieved by the accelerated technological progress in protein separation and identification will help in going beyond the simple cataloguing of rice proteins in realistic terms. In this review, we discuss the progress made in the field of rice proteomics to date and dwell upon the future direction/problems/approaches towards defining the rice proteome.
The metabolic syndrome is associated with reduced central serotonergic responsivity in healthy community volunteers.

CONTEXT The pathobiology of the metabolic syndrome remains unclear. The central nervous system is likely to be involved via regulation of eating, physical activity, blood pressure, and metabolism. OBJECTIVE The objective of this study was to test the hypothesis that low central serotonergic activity is associated with the metabolic syndrome. DESIGN, SETTING, PARTICIPANTS This was a cross-sectional study of 345 healthy community volunteers, aged 30-55 yr, not taking medications for hypertension, lipid disorders, or diabetes. OUTCOME MEASURES Central serotonergic responsivity was assessed with the iv citalopram challenge test. The serum prolactin area under the curve (AUC) over 150 min was calculated, and all analyses were adjusted for age, sex, plasma citalopram concentration, and baseline prolactin. The metabolic syndrome was defined according to the National Cholesterol Education Program (NCEP) and International Diabetes Federation (IDF) criteria. Insulin resistance was estimated by homeostasis model assessment. RESULTS Compared with other individuals, persons meeting either NCEP or IDF criteria for the metabolic syndrome had lower mean prolactin responses (P < 0.05 for both). Using logistic regression, a decrease in prolactin AUC of 1 sd (-13.6 ng/ml.h) more than doubled the odds of having the metabolic syndrome (NCEP criteria: odds ratio, 2.38; 95% confidence interval, 1.14-4.97; P = 0.02; IDF criteria: odds ratio, 2.80; 95% confidence interval, 1.48-5.30; P = 0.002). Finally, the prolactin AUC was negatively associated with insulin resistance (beta = -0.03, P = 0.02). CONCLUSIONS Corroborating previous evidence, the metabolic syndrome was associated with diminished brain serotonergic activity as reflected in a comparative blunting of the prolactin response to a selective serotonergic challenge. This association may have implications for the etiology, prevention, and treatment of the metabolic syndrome.
When Did the Paleotethys Ailaoshan Ocean Close: New Insights From Detrital Zircon U‐Pb age and Hf Isotopes

We present new laser ablation (LA)‐multicollector‐inductively coupled plasma mass spectrometry detrital zircon U‐Pb age and Hf isotope data of the Triassic sedimentary rocks from the eastern and western sides of the Ailaoshan suture in SW China, which separate the Indochina and South China blocks. Detrital zircon grains of the Lower‐Middle Triassic sequences from western South China show single age population of 280–237 Ma (peak at 254–251 Ma) with mainly positive εHf(t) values (+0.15 to +9.11, ~60%). The Middle Triassic samples from eastern Indochina also contain single age population of 273–236 Ma (peak at 246–242 Ma), but with mainly negative εHf(t) values (−18.95 to −1.83, ~88%). The unimodal detrital zircon age pattern and Hf isotope features suggest that the Permian‐Triassic magmatic arcs had supplied detritus for the Lower‐Middle Triassic sequences on both sides of the Ailaoshan suture. In contrast, the Upper Triassic sequences on the either side of the suture display similar polymodal age populations at 290–230, 500–400, 850–700, 1000–900, 2000–1800, and 2600–2400 Ma. This indicates a dramatic change in detrital provenance across the Middle‐Late Triassic boundary. We interpret this change to be resulted from the closure of the Paleotethyan Ailaoshan Ocean in the early Late Triassic. The ocean closure and consequent Indochina‐South China continent‐continent collision may have connected the drainage systems of the two blocks, leading to the marked similarities in their post‐Middle Triassic sedimentary provenance.