Miracle-dz/UniFAR-FTUs huggingface dataset:
α1‐Adrenergic Receptor Mediates Arachidonic Acid Release in Spinal Cord Neurons Independent of Inositol Phospholipid Turnover

The α1‐adrenergic receptor has been shown to mediate the release of arachidonic acid in FRTL5 thyroid cells and MDCK kidney cells. In primary cultures of spinal cord cells, norepinephrine stimulated release of arachidonic acid (from neurons only) and turnover of inositol phospholipids (from neurons and glia) via α1‐adrenergic receptors. These two responses were dissociated by treatment with phorbol ester and pertussis toxin, which inhibited production of inositol phosphates with no appreciable effect on release of arachidonic acid. Extracellular calcium was required for release of arachidonic acid, but not for production of inositol phosphates. The calcium channel blockers nifedipine and verapamil inhibited release of arachidonic acid only. However, 8‐(N,N‐diethylamino)octyl‐3,4,5‐trimethoxybenzoate (TMB‐8), a compound that blocks intracellular calcium release, diminished production of inositol phosphates, but had little effect on release of arachidonic acid. These results suggest that α1‐adrenergic receptors couple to release of arachidonic acid in primary cultures of spinal cord cells by a mechanism independent of activation of phospholipase C, possibly via the activation of phospholipase A2.
Partitioning An Assembly For Infinitesimal Motions In Translation And Rotation

The problem of partitioning an assembly into two subassemblies that can be separated arises in assembly planning. We consider assemblies of rigid parts whose contacts are equivalent, in terms of motion constraints, to finite sets of point-plane contact constraints. This type of contact includes all stable contacts between polyhedra as well as the large majority of contacts seen in industrial assemblies. For such assemblies, we describe a general algorithm to And a subassembly that is free to rotate and translate a small distance from the rest of the assembly. For assemblies with m contacts described as k point-plane constraints, the algorithm has a worst-case time bound of 0(~k5).
Prosocial Moral Reasoning in Institutionalized Delinquent, Orphaned, and Noninstitutionalized Brazilian Adolescents

Researchers have postulated sociocognitive differences between delinquent and nondelinquent youths. However, prior studies have examined differences in prohibitive moral reasoning, and no studies of prosocial moral reasoning have been conducted with orphaned adolescents or in countries other than the United States. We examined prosocial moral reasoning in Brazilian institutionalized delinquent, orphaned, and noninstitutionalized adolescents. Delinquent, relative to nondelinquent, adolescents were expected to be less likely topreferhigherlevel, internalized types ofprosocial moral reasoning and more likely toprefer lowerlevels ofprosocial moral reasoning. No specific hypotheses were made regarding prosocial moral reasoning in orphaned adolescents. A total of 116 male andfemale Brazilian adolescents (38 delinquent, 38 orphaned, and 40 noninstitutionalized adolescents) were administered an objective measure of prosocial moral reasoning (PROM). In general, the main hypotheses were supported, and gender differences werefound. Discussionfocused on the correlates of prosocial moral reasoning and institutionalization in adolescence.
Palpation of Muscle and Skin. Is this a Reliable and Valid Procedure in Assessment of Patients with Long-lasting Musculoskeletal Pain?

The aims of this study were to investigate reliability and aspects of validity of a previously developed method called the Global Physiotherapeutic Muscle Examination (GPM), which comprises items related to palpation of Muscle (18 items) and Skin (12 items). Inter-tester reliability was examined by three physiotherapists examining 19 persons. Construct and discriminative validity was studied by data from 247 patients with long-lasting musculoskeletal pain and 104 healthy subjects. For the patients, concurrent validity was examined by correlating psychological functioning, measured with the revised version of the Minnesota Multiphasic Personality Inventory (MMPI-2), as well as information about pain, with the domains of Muscle and Skin. Reliability was acceptable, with overall intra-class correlation coefficients ranging from 0.54 to 0.84, but with low measurement error. Construct evaluation was done by means of Structural Equation Modeling (SEM), resulting in a modified and improved model with fewer tests: 12 within Muscle and eight within Skin. Composite scores of palpation differed significantly between healthy subjects and patients, and between sub-groups of patients. A relationship was found between Muscle and Skin and psychological characteristics, but differently for females and males. Pain showed a low but significant correlation only to the Muscle domain. The items included in a modified model of palpation can be used in a reliable and valid way when screening patients with long-lasting pain.
A Miniaturized UWB Biplanar Yagi-Like MIMO Antenna System

A novel 2-element ultrawideband Yagi-based multiple-input–multiple-output (MIMO) antenna system is presented based on loop excitation. Half of the driven loop element is implemented on each side of the substrate, which not only reduces the overall size of the antenna by <inline-formula><tex-math notation="LaTeX">${\text{45}}\%$</tex-math> </inline-formula>, but also increases its bandwidth significantly. The center frequency of operation is 5.8 GHz targeting WLAN applications. The proposed design has a wide measured bandwidth of 2.401 GHz covering 4.183–6.584 GHz. The proposed compact MIMO antenna system has an overall size of <inline-formula> <tex-math notation="LaTeX">${\text{50}}\times {\text{80}}\times {\text{0.76}}$</tex-math></inline-formula> mm <inline-formula><tex-math notation="LaTeX">$^3$</tex-math></inline-formula> with a single element size of <inline-formula><tex-math notation="LaTeX">${\text{50}}\times {\text{40}}\times {\text{0.76}}$</tex-math> </inline-formula> mm<inline-formula><tex-math notation="LaTeX">$^3$</tex-math></inline-formula>. The proposed Yagi antenna has high directional radiation characteristics with a minimum measured front-to-back ratio of 18 dB, minimum measured gain of 6 dBi, and directivity of 6.6 dB using a single director element only, at 5.8 GHz. It has a minimum measured isolation of 17 dB, measured maximum envelope correlation coefficient value of 0.0568, and measured total efficiency above <inline-formula><tex-math notation="LaTeX">$80\%$</tex-math> </inline-formula> across the band of operation.
Mechanism Design and Implementation for Lung Exchange

We explore the mechanism design problem for lung exchange and its implementation in practice. We prove that determining whether there exists a non-trivial solution of the lung exchange problem is NP-complete. We propose a mechanism that is individually rational, strategy-proof and maximizes exchange size. To implement this mechanism in practice, we propose an algorithm based on Integer Linear Program and another based on search. Both of our algorithms for this mechanism yield excellent performances in simulated data sets.
The Evolving Discipline of Public Affairs

Approaching the tenth anniversary of this Journal of Public Affairs, as the editorial team we offer this extended literature review as our reflection on the evolution and development of public affairs, both as an academic discipline and a professional practice. It is a necessarily personal and subjective contribution, highlighting the issues and areas which we believe represent significant continuing debates. The article considers how public affairs is, and should be, defined; examines the range of activities which theorists and practitioners understand as falling within the scope of corporate public affairs; analyses the relationship between public affairs and corporate political activity as different though complementary fields; discusses the importance of the public issues life cycle and the issues management models; and calls upon the public affairs community to defend the position of public affairs as the fundamental bridge between the organisation, society and government, in the face of challenges from other organisational functions. Copyright © 2010 John Wiley & Sons, Ltd.
Project strategy: strategy types and their contents in innovation projects

Purpose – Previous literature on project strategy has adopted the narrow view that a project is to be conducted under the governance of a single strong sponsor or parent organization. The purpose of this study is to provide a critical analysis on prior project management (PM) literature addressing different context‐specific strategies of single projects.Design/methodology/approach – Literature analysis.Findings – There are two important determinants in the project's context that affect the strategy of a single project: a project's autonomy in its environment and the complexity of project's stakeholder environment. Based on these two determinants, we characterize four types of alternative positions that projects can have in their context: parent's subordinate and autonomous projects that occur in a stakeholder environment that is not complex, and projects with weak and autonomous positions in a complex stakeholder environment. The developed project strategy framework is applied in the context of innovation.
Judicial rhetoric, meaning-making, and the institutionalization of hate crime law

In this article we examine how the concept of hate crime has been transformed in judicial discourse from a broad ambiguous category, which generated substantial controversy and opposition, to a focused determinate legal construct, which has been largely accepted as a legitimate legal practice. We track changes in judicial rhetoric across 38 appellate court opinions that consider the constitutionality of hate crime cases (1984-1999), and we propose a theoretical framework for analyzing the "settling" of legal meaning. A qualitative interpretive analysis demonstrates that the meaning of hate crime that emerges across the series of cases is much richer and nuanced than the collection of words contained in the statutes, and that the domain of hate crime has expanded across the series of cases to include a broader range of behaviors and mental precursors. Quantitative analysis shows that, over time, judges have developed a more economical and formulaic rhetoric for responding to petitioners' constitutional challenges to hate crime statutes and have converged around sets of arguments for negotiating challenges. We discuss the implications of these findings for traditional jurisprudential analyses, sociolegal research on judicial decisionmaking, and research on the social construction of deviance.
Genetic Severity Score predicts clinical phenotype in NF2

​Background The clinical severity of disease in neurofibromatosis type 2 (NF2) is variable. Patients affected with a constitutional truncating NF2 mutation have severe disease, while missense mutations or mosaic mutations present with a milder attenuated phenotype. Genotype-derived natural history data are important to inform discussions on prognosis and management. Methods We have assessed NF2 clinical phenotype in 142 patients in relation to the UK NF2 Genetic Severity Score to validate its use as a clinical and research tool. Results The Genetic Severity Score showed significant correlations across 10 measures, including mean age at diagnosis, proportion of patients with bilateral vestibular schwannomas, presence of intracranial meningioma, spinal meningioma and spinal schwannoma, NF2 eye features, hearing grade, age at first radiotherapy, age at first surgery and age starting bevacizumab. In addition there was moderate but significant correlation with age at loss of useful hearing, and weak but significant correlations for mean age at death, quality of life, last optimum Speech Discrimination Score and total number of major interventions. Patients with severe disease presented at a younger age had a higher disease burden and greater requirement of intervention than patients with mild and moderate disease. Conclusions This study validates the UK NF2 Genetic Severity Score to stratify patients with NF2 for both clinical use and natural history studies.
Phosphorus Nutrition of Proteaceae in Severely Phosphorus-Impoverished Soils: Are There Lessons To Be Learned for Future Crops?1

Australia harbors some of the most nutrient-impoverished soils on Earth. Southwestern Australian soils are especially phosphorus (P) impoverished, due to the age of this ancient landscape and it being unaffected by major geological disturbance for millions of years ([Hopper, 2009][1]; [Lambers et al
The Limits of Family Influence: Genes, Experience, and Behavior

How can you change your mind to be more open? There many sources that can help you to improve your thoughts. It can be from the other experiences and also story from some people. Book is one of the trusted sources to get. You can find so many books that we share here in this website. And now, we show you one of the best, the the limits of family influence genes experience and behavior by david c rowe 1995 08 02.
Pharmacology of Modulators of Alternative Splicing

More than 95% of genes in the human genome are alternatively spliced to form multiple transcripts, often encoding proteins with differing or opposing function. The control of alternative splicing is now being elucidated, and with this comes the opportunity to develop modulators of alternative splicing that can control cellular function. A number of approaches have been taken to develop compounds that can experimentally, and sometimes clinically, affect splicing control, resulting in potential novel therapeutics. Here we develop the concepts that targeting alternative splicing can result in relatively specific pathway inhibitors/activators that result in dampening down of physiologic or pathologic processes, from changes in muscle physiology to altering angiogenesis or pain. The targets and pharmacology of some of the current inhibitors/activators of alternative splicing are demonstrated and future directions discussed.
Quasi-static electric field in a cylindrical volume conductor induced by external coils [human body application]

An expansion technique based on modified Bessel functions is used to obtain an analytical solution for the electric held induced in a homogeneous cylindrical volume conductor by an external coil. The current in the coil is assumed to be changing slowly so that quasi-static conditions can be justified. Valid for any coil type, this solution is ideal for fast computation of the induced electric held at a large number of points. Efficient implementation of this method in a computer code is described and numerical results are presented for a perpendicular circular coil and a tangential double-square coil. <<ETX>>
Apocynum Tablet Protects against Cardiac Hypertrophy via Inhibiting AKT and ERK1/2 Phosphorylation after Pressure Overload

Background. Cardiac hypertrophy occurs in many cardiovascular diseases. Apocynum tablet (AT), a traditional Chinese medicine, has been widely used in China to treat patients with hypertension. However, the underlying molecular mechanisms of AT on the hypertension-induced cardiac hypertrophy remain elusive. The current study evaluated the effect and mechanisms of AT on cardiac hypertrophy. Methods. We created a mouse model of cardiac hypertrophy by inducing pressure overload with surgery of transverse aortic constriction (TAC) and then explored the effect of AT on the development of cardiac hypertrophy using 46 mice in 4 study groups (combinations of AT and TAC). In addition, we evaluated the signaling pathway of phosphorylation of ERK1/2, AKT, and protein expression of GATA4 in the cardioprotective effects of AT using Western blot. Results. AT inhibited the phosphorylation of Thr202/Tyr204 sites of ERK1/2, Ser473 site of AKT, and protein expression of GATA4 and significantly inhibited cardiac hypertrophy and cardiac fibrosis at 2 weeks after TAC surgery (P < 0.05). Conclusions. We experimentally demonstrated that AT inhibits cardiac hypertrophy via suppressing phosphorylation of ERK1/2 and AKT.
Comparison of Single Event Transients Generated at Four Pulsed-Laser Test Facilities-NRL, IMS, EADS, JPL

Four pulsed-laser single-event effects systems, differing in wavelength and pulse width, were used to generate single event transients in a large-area silicon photodiode and an operational amplifier (LM124) to determine how transient amplitude and charge collection varied among the different systems. The optical wavelength and the focused spot size are the primary factors influencing the resultant charge density profile. In the large-area photodiode the transients can be distorted by high charge-injection densities that occur for tightly focused, higher energy optical pulses. When the incident laser-pulse energies are corrected for reflection losses and photon efficiency, with collection depth as a floating parameter (to account for diffusion), the photodiode data for all four devices lie on a single curve. The LM124 response varies with the specific transistor irradiated; similar transient shapes are measured for the different pulse wavelengths, with some deviations in the case of R1. These results reiterate that there is no single, optimum pulsed-laser system for SEE studies; that choice depends on the device to be tested, the intended application of that device, the goals of the test, and availability. For the specific devices evaluated here, any of the four laser systems would be sufficient for most tests.
N degrees of separation: multi-dimensional separation of concerns

Done well, separation of concerns can provide many software engineering benefits, including reduced complexity, improved reusability, and simpler evolution. The choice of boundaries for separate concerns depends on both requirements on the system and on the kind(s) of decomposition and composition a given formalism supports. The predominant methodologies and formalisms available, however, support only orthogonal separations of concerns, along single dimensions of composition and decomposition. These characteristics lead to a number of well-known and difficult problems. The paper describes a new paradigm for modeling and implementing software artifacts, one that permits separation of overlapping concerns along multiple dimensions of composition and decomposition. This approach addresses numerous problems throughout the software lifecycle in achieving well-engineered, evolvable, flexible software artifacts and traceability across artifacts.
- 1-EEG-Based Emotion Recognition during Music Listening

In Music Emotion Research, the goal is to quantify and explain how music influences our emotional states. Scientists realize that human brain is relevant to emotion, and it leads to the study of human emotion by capturing information from brain. Electroencephalogram (EEG) is an efficient tool to capture brainwave. This research proposes a framework to recognize human emotions during music listening by using EEG. In this research, MIDI music files are used, 12 electrodes of EEG are selected and placed according to the 10-20 international standard. Two-Dimensional emotion model is used to represent human emotions. The experiment starts from music selection, music listening with brainwave capturing, and ends with emotion self-annotation continuously. For data analysis, Fractal Dimension value calculations by Higuchi Algorithm are performed, and Support Vector Machine is applied. The results of emotion classification are satisfied, with the accuracy of 90% for arousal classification and 86% for valence classification on average.
Suggests the Presence of Autocrine and Paracrine Loops Glioma Tissue : Expression of Messenger RNA and Protein Platelet-derived Growth Factor and Its Receptors in Human Updated

The expression of platelet-derived growth factor (PDGF) and its receptors was analyzed in 14 gliomas of various degrees of malignancy and compared with three gliosis cases by in situ hybridization and immunohistochemistry techniques. Expression of both PDGF Aand Bchains was higher in glioblastomas than in astrocytomas. The PDGF Achain niKNA was predominantly found in cell-rich areas in glioblastomas. The cognate PDGF-a receptor (PDGFR-cr) mRNA was heterogeneously distributed in gliomas of all grades, and PDGFR-a expression was higher in gliomas than in gliosis. Within some glioblastomas probed with PDGFR-a complementary RNA, cells heavily loaded with grains were intermingled with others containing low or moderate signals. The heavilylabeled cells were often found in the vicinity of proliferating capillaries. Immunostaining with an anti-PDGF antibody and an affinity-purified antisemiti against the PDGFR-a showed strong staining of most tumor cells with both antibodies in glioblastoma. In addition, the PDGFR-a antibodies yielded a strong staining of scattered cells, and the anti-PDGF antibody yielded staining of a few cells within the astrocytoma. Further more, high levels of the PDGF-/3 receptor (PDGFR-0) and PDGF Bchain mRNA as well as the 0 receptor protein were found in hyperplastic capillaries. These results suggest the presence of autocrine and paracrine loops in glioma, activating the PDGFR-a in glioma cells and the PDGFR0 in endothelial cells.
Domestic property and social class

Cet expose traite de l'importance des consequences des differents modes d'occupation de logement, en ce qui concerne les rapports de classes. L'accent est mis precisement sur la Grande Bretagne ou, environ 40% des ouvriers manuels possedent maintenant leur propre maison, et ou l'extension de l'occupation de l'habitation par le proprietaire a nettement contribue a accroitre les dividions sociales et politiques, au sein de la classe ouvriere. La question qui se pose, est de savoir si de telles divisions ont une base materielle reelle, ou si elles sont principalement ideologiques. On voit que la reponse a cette question aura d'importantes consequences pour l'organisation de luttes politiques autour de la question du logement. L'expose debute par une discussion des perspectives weberiennes et marxistes en matiere d'occupation de logement et de rapports de classes. La perspective weberienne, liee aux travaux de Rex et de Moore sur 'le logement par classes', est rejetee, quoique la possibilite de reformuler le concept du logement par classes, au sein d'une orientation weberienne, soit mise en evidence. Le point de vue marxiste, qui rejette la possession du logement comme etant etrangere a l'identification des interets de classe, est egalement rejete, sous pretexte que l'occupation de l'habitation par le proprietaire est un facteur crucial d'une augmentation reelles des richesses individuelles qui peuvent largement depasser les economics que l'on peut faire sur les salaires de toute une vie. L 'expose montre ensuite, comment la possession de sa maison va dans le sens d'une accumulation des richesses, et comment ceci cree une reelle division d'interet economique entre les proprietaires en jouissance et les locataires, fait qui se manifeste souvent dans les luttes politiques locales. La conclusion qui se degage de ceci est que, les efforts des activistes locaux pour unifier les deux groupes en une alliance politique contre le capital monopole, peut saverer a la fois peu judicieux et nuisible a la productivite.
New Methods in using a Manipulator for Autonomous Victim Detection

In the present paper, we aim at examining the various aspects of using a robot as a rescuer to identify and localize the victims. Our robot serves as a mobile platform for carrying a 3-DOF1 manipulator mounted on it. The presented robot has the ability to completely detect and localize the victim in environments referred to as yellow and orange arena in NIST terminology (A. Jacoff et al., 2001). In this paper, these types of environments which are more structured are classified as 2D environments such as an office environment. In unstructured environments, which are classified as 3D environments, the victims can be found in a semi-autonomous manner. These environments are called the red arena in NIST terminology