Miracle-dz/UniFAR-FTUs huggingface dataset:
Plyometric Training in Female Athletes

The purpose of this study was to test the effect of a jump-training program on landing mechanics and lower extremity strength in female athletes involved in jump ing sports. These parameters were compared before and after training with those of male athletes. The program was designed to decrease landing forces by teaching neuromuscular control of the lower limb dur ing landing and to increase vertical jump height. After training, peak landing forces from a volleyball block jump decreased 22%, and knee adduction and abduc tion moments (medially and laterally directed torques) decreased approximately 50%. Multiple regression analysis revealed that these moments were significant predictors of peak landing forces. Female athletes demonstrated lower landing forces than male athletes and lower adduction and abduction moments after training. External knee extension moments (hamstring muscle-dominant) of male athletes were threefold higher than those of female athletes. Hamstring-to- quadriceps muscle peak torque ratios increased 26% on the nondominant side and 13% on the dominant side, correcting side-to-side imbalances. Hamstring muscle power increased 44% with training on the dom inant side and 21 % on the nondominant. Peak torque ratios of male athletes were significantly greater than those of untrained female athletes, but similar to those of trained females. Mean vertical jump height in creased approximately 10%. This training may have a significant effect on knee stabilization and prevention of serious knee injury among female athletes.
Introduction to the Virtual Issue Alcohol and Epigenetic Regulation: Do the Products of Alcohol Metabolism Drive Epigenetic Control of Gene Expression in Alcohol-Related Disorders?

Epigenetic regulation, the persistent change in the gene regulatory state following a transient environmental perturbation, has become increasingly prominent in accounting for the consequences of exposure to addictive substances, including alcohol (ethanol). The purpose of this Virtual Issue is to draw attention to some of the recent advances in our understanding of how consumption of alcohol impacts the epigenetic landscape and causes such persistent changes in the regulation of gene expression and cellular function that affect behavior or disease susceptibility well after the alcohol challenge has occurred. Articles that recently appeared in ACER are placed in the context of the broader relevant literature and emerging opportunities. This article is protected by copyright. All rights reserved.
Intracellular, In Vivo, Dynamics of Thalamocortical Synapses in Visual Cortex

Seminal studies of the thalamocortical circuit in the visual system of the cat have been central to our understanding of sensory encoding. However, thalamocortical synaptic properties remain poorly understood. We used paired recordings, in the lateral geniculate nucleus (LGN) and primary visual cortex (V1), to provide the first in vivo characterization of sensory-driven thalamocortical potentials in V1. The amplitudes of EPSPs we characterized were smaller than those previously reported in vitro. Consistent with prior findings, connected LGN-V1 pairs were only found when their receptive fields (RFs) overlapped, and the probability of connection increased steeply with degree of RF overlap and response similarity. However, surprisingly, we found no relationship between EPSP amplitudes and the similarity of RFs or responses, suggesting different connectivity models for intracortical and thalamocortical circuits. Putative excitatory regular-spiking (RS) and inhibitory fast-spiking (FS) V1 cells had similar EPSP characteristics, showing that in the visual system, feedforward excitation and inhibition are driven with equal strength by the thalamus. Similar to observations in the somatosensory cortex, FS V1 cells received less specific input from LGN. Finally, orientation tuning in V1 was not inherited from single presynaptic LGN cells, suggesting that it must emerge exclusively from the combined input of all presynaptic LGN cells. Our results help to decipher early visual encoding circuits and have immediate utility in providing physiological constraints to computational models of the visual system. SIGNIFICANCE STATEMENT To understand how the brain encodes the visual environment, we must understand the transfer of visual signals between various regions of the brain. Therefore, understanding synaptic dynamics is critical to our understanding of sensory encoding. This study provides the first characterization of visually evoked synaptic potentials between the visual thalamus and visual cortex in an intact animal. To record these potentials, we simultaneously recorded the extracellular potential of presynaptic thalamic cells and the intracellular potential of postsynaptic cortical cells in input layers of primary visual cortex. Our characterization of synaptic potentials in vivo disagreed with prior findings in vitro. This study will increase our understanding of thalamocortical circuits and will improve computational models of visual encoding.
Field intercomparison of four methane gas analyzers suitable for eddy covariance flux measurements

Performances of four methane gas analyzers suitable for eddy covariance measurements are assessed. The assessment and comparison was performed by analyzing eddy covariance data obtained during summer 2010 (1 April to 26 October) at a pristine fen, Siikaneva, Southern Finland. High methane fluxes with pronounced seasonality have been measured at this fen. The four participating methane gas analyzers are commercially available closed-path units TGA-100A (Campbell Scientific Inc., USA), RMT-200 (Los Gatos Research, USA), G1301-f (Picarro Inc., USA) and an early prototype open-path unit Prototype-7700 (LI-COR Biosciences, USA). The RMT-200 functioned most reliably throughout the measurement campaign, during low and high flux periods. Methane fluxes from RMT-200 and G1301-f had the smallest random errors and the fluxes agree remarkably well throughout the measurement campaign. Cospectra and power spectra calculated from RMT-200 and G1301-f data agree well with corresponding temperature spectra during a high flux period. None of the gas analyzers showed statistically significant diurnal variation for methane flux. Prototype-7700 functioned only for a short period of time, over one month, in the beginning of the measurement campaign during low flux period, and thus, its overall accuracy and season-long performance were not assessed. The open-path gas analyzer is a practical choice for measurement sites in remote locations due to its low power demand, whereas for G1301-f methane measurements interference from water vapor is straightforward to correct since the instrument measures both gases simultaneously. In any case, if only the performance in this intercomparison is considered, RMT-200 performed the best and is the recommended choice if a new fast response methane gas analyzer is needed.
Structural and Optical Properties of ZnO Film Precursors for Multilayered Transparent Solar Cell Electrodes

This work examines the modification of the structural and optical properties of ZnO thin films by control of deposition and post-treatment parameters. ZnO thin films were deposited by RF magnetron sputtering from a ceramic target locally made at SHESTCO in Abuja, Nigeria. X-ray diffraction measurements characterized the different films prior to thermal annealing as extremely amorphous with average UV-VIS transmittance spectra between 80 and 90%. Annealing at different temperatures and time spans influenced the formation of Wurtzite (002) oriented ZnO crystallites. Contrary to the crystallinity of the films, which was strongly influenced by the deposition power, the optical transmission of the films was only slightly influenced by the deposition power and it was less sensitive to the crystallinity of ZnO thin films.
Trends in bidi and cigarette smoking in India from 1998 to 2015, by age, gender and education

Objectives Smoking of cigarettes or bidis (small, locally manufactured smoked tobacco) in India has likely changed over the last decade. We sought to document trends in smoking prevalence among Indians aged 15–69 years between 1998 and 2015. Design Comparison of 3 nationally representative surveys representing 99% of India's population; the Special Fertility and Mortality Survey (1998), the Sample Registration System Baseline Survey (2004) and the Global Adult Tobacco Survey (2010). Setting India. Participants About 14 million residents from 2.5 million homes, representative of India. Main outcome measures Age-standardised smoking prevalence and projected absolute numbers of smokers in 2015. Trends were stratified by type of tobacco smoked, age, gender and education level. Findings The age-standardised prevalence of any smoking in men at ages 15–69 years fell from about 27% in 1998 to 24% in 2010, but rose at ages 15–29 years. During this period, cigarette smoking in men became about twofold more prevalent at ages 15–69 years and fourfold more prevalent at ages 15–29 years. By contrast, bidi smoking among men at ages 15–69 years fell modestly. The age-standardised prevalence of any smoking in women at these ages was 2.7% in 2010. The smoking prevalence in women born after 1960 was about half of the prevalence in women born before 1950. By contrast, the intergenerational changes in smoking prevalence in men were much smaller. The absolute numbers of men smoking any type of tobacco at ages 15–69 years rose by about 29 million or 36% in relative terms from 79 million in 1998 to 108 million in 2015. This represents an average increase of about 1.7 million male smokers every year. By 2015, there were roughly equal numbers of men smoking cigarettes or bidis. About 11 million women aged 15–69 smoked in 2015. Among illiterate men, the prevalence of smoking rose (most sharply for cigarettes) but fell modestly among men with grade 10 or more education. The ex-smoking prevalence in men at ages 45–59 years rose modestly but was low: only 5% nationally with about 4 current smokers for every former smoker. Conclusions Despite modest decreases in smoking prevalence, the absolute numbers of male smokers aged 15–69 years has increased substantially over the last 15 years. Cigarettes are displacing bidi smoking, most notably among young adult men and illiterate men. Tobacco control policies need to adapt to these changes, most notably with higher taxation on tobacco products, so as to raise the currently low levels of adult smoking cessation.
Association of Borderline Pulmonary Hypertension With Mortality and Hospitalization in a Large Patient Cohort: Insights From the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program

Background— Pulmonary hypertension (PH) is associated with increased morbidity across the cardiopulmonary disease spectrum. Based primarily on expert consensus opinion, PH is defined by a mean pulmonary artery pressure (mPAP) ≥25 mm Hg. Although mPAP levels below this threshold are common among populations at risk for PH, the relevance of mPAP <25 mm Hg to clinical outcome is unknown. Methods and Results— We analyzed retrospectively all US veterans undergoing right heart catheterization (2007–2012) in the Veterans Affairs healthcare system (n=21 727; 908-day median follow-up). Cox proportional hazards models were used to evaluate the association between mPAP and outcomes of all-cause mortality and hospitalization, adjusted for clinical covariates. When treating mPAP as a continuous variable, the mortality hazard increased beginning at 19 mm Hg (hazard ratio [HR]=1.183; 95% confidence interval [CI], 1.004–1.393) relative to 10 mm Hg. Therefore, patients were stratified into 3 groups: (1) referent (⩽18 mm Hg; n=4 207); (2) borderline PH (19–24 mm Hg; n=5 030); and (3) PH (≥25 mm Hg; n=12 490). The adjusted mortality hazard was increased for borderline PH (HR=1.23; 95% CI, 1.12–1.36; P<0.0001) and PH (HR=2.16; 95% CI, 1.96–2.38; P<0.0001) compared with the referent group. The adjusted hazard for hospitalization was also increased in borderline PH (HR=1.07; 95% CI, 1.01–1.12; P=0.0149) and PH (HR=1.15; 95% CI, 1.09–1.22; P<0.0001). The borderline PH cohort remained at increased risk for mortality after excluding the following high-risk subgroups: (1) patients with pulmonary artery wedge pressure >15 mm Hg; (2) pulmonary vascular resistance ≥3.0 Wood units; or (3) inpatient status at the time of right heart catheterization. Conclusions— These data illustrate a continuum of risk according to mPAP level and that borderline PH is associated with increased mortality and hospitalization. Future investigations are needed to test the generalizability of our findings to other populations and study the effect of treatment on outcome in borderline PH.
Analysing BitTorrent's Seeding Strategies

BitTorrent is a typical peer-to-peer (P2P) file distribution application that has gained tremendous popularity in recent years. A considerable amount of research exists regarding BitTorrent’s choking algorithm, which has proved to be effective in preventing freeriders. However, the effect of the seeding strategy on the resistance to freeriders in BitTorrent has been largely overlooked. In addition to this, a category of selfish leechers (termed exploiters), who leave the overlay im-mediately after completion, has never been taken into account in previous research. In this paper two popular seeding strate-gies, the Original Seeding Strategy (OSS) and the Time-based Seeding Strategy (TSS), are chosen and we study, via mathe-matical models and simulation, their effects on freeriders and exploiters in BitTorrent networks. The mathematical model is verified and we discover that both freeriders and exploiters impact on system performance, despite the seeding strategy that is employed. However, a selfish-leecher’s threshold is identified; once this threshold is exceeded, we find that TSS outperforms OSS – that is, TSS reduces the negative impact of selfish lechers more effectively than OSS. Based on these results we discuss the choice of seeding strategy and speculate as to how more effective BitTorrent-based file distribution appli-cations can be built.
Preparation and Characterization of Natural Rubber Composites Comprising Conductive Carbon Black/Magnetite Hybrid Fillers Obtained by Impregnation Technology

ABSTRACT Hybrid fillers have been prepared of conductive carbon black/magnetite at various ratios of the phases: 90:10, 70:30, and 50:50. The fillers have been characterized and their effect on the curing, mechanical, electric, and dynamic properties of natural rubber–based vulcanizates has been also investigated. The macrohomogeneity of the composites has been evaluated by ohmic resistivity measurements and correlation analysis. It has been established that all properties studied are dependent on the ratio between the filler’s phases. Viewing their composition, we conclude that the hybrid fillers are expected to exhibit both high dielectric and magnetic losses and may find application in the manufacturing of microwave absorbers. GRAPHICAL ABSTRACT
Optimization of the cycle time in resin transfer molding process by numerical simulation

Resin transfer molding is a popular manufacturing process for composite materials because of its ability to manufacture complex-shaped parts with high efficiency and low pollution. Despite the intense interest in the modeling and simulation of this process, minimization of mold filling time without losing the part quality remains an important issue in the resin transfer molding process. Various methods in the literature are suggested to achieve this. However, inappropriate injection methods lead to numerous air entrapments, and fiber mat deformation. In this study, we are interested in developing and improving new methods to optimize the cycle time. The effects of several parameters on the filling process are deeply investigated. A computer code based on the control volume finite element method is developed to study the mold filling process in all cases. The validity of the computer code used is checked by analytical results and close agreement is found.
Metapopulation dominance and genomic-island acquisition of Bradyrhizobium with superior catabolic capabilities

Root nodule-forming rhizobia exhibit a bipartite lifestyle, replicating in soil and also within plant cells where they fix nitrogen for legume hosts. Host control models posit that legume hosts act as a predominant selective force on rhizobia, but few studies have examined rhizobial fitness in natural populations. Here, we genotyped and phenotyped Bradyrhizobium isolates across more than 800 km of the native Acmispon strigosus host range. We sequenced chromosomal genes expressed under free-living conditions and accessory symbiosis loci expressed in planta and encoded on an integrated ‘symbiosis island’ (SI). We uncovered a massive clonal expansion restricted to the Bradyrhizobium chromosome, with a single chromosomal haplotype dominating populations, ranging more than 700 km, and acquiring 42 divergent SI haplotypes, none of which were spatially widespread. For focal genotypes, we quantified utilization of 190 sole-carbon sources relevant to soil fitness. Chromosomal haplotypes that were both widespread and dominant exhibited superior growth on diverse carbon sources, whereas these patterns were not mirrored among SI haplotypes. Abundance, spatial range and catabolic superiority of chromosomal, but not symbiosis genotypes suggests that fitness in the soil environment, rather than symbiosis with hosts, might be the key driver of Bradyrhizobium dominance.
Counterpoint: long-term antibiotic therapy improves persistent symptoms associated with lyme disease.

BACKGROUND Controversy exists regarding the diagnosis and treatment of Lyme disease. Patients with persistent symptoms after standard (2-4-week) antibiotic therapy for this tickborne illness have been denied further antibiotic treatment as a result of the perception that long-term infection with the Lyme spirochete, Borrelia burgdorferi, and associated tickborne pathogens is rare or nonexistent. METHODS I review the pathophysiology of B. burgdorferi infection and the peer-reviewed literature on diagnostic Lyme disease testing, standard treatment results, and coinfection with tickborne agents, such as Babesia, Anaplasma, Ehrlichia, and Bartonella species. I also examine uncontrolled and controlled trials of prolonged antibiotic therapy in patients with persistent symptoms of Lyme disease. RESULTS The complex "stealth" pathology of B. burgdorferi allows the spirochete to invade diverse tissues, elude the immune response, and establish long-term infection. Commercial testing for Lyme disease is highly specific but relatively insensitive, especially during the later stages of disease. Numerous studies have documented the failure of standard antibiotic therapy in patients with Lyme disease. Previous uncontrolled trials and recent placebo-controlled trials suggest that prolonged antibiotic therapy (duration, >4 weeks) may be beneficial for patients with persistent Lyme disease symptoms. Tickborne coinfections may increase the severity and duration of infection with B. burgdorferi. CONCLUSIONS Prolonged antibiotic therapy may be useful and justifiable in patients with persistent symptoms of Lyme disease and coinfection with tickborne agents.
Study on Sensing Properties of Electro-spun PEO/MWNT Non-woven Fabric

This paper presents a study on the sensing properties of a conductive polymer composite (CPC) that is processed by an electrospinning technique. The CPC is obtained by mixing multi-walled carbon nanotubes (MWNT) with a poly (ethylene oxide) (PEO) matrix. Sensors made of this composite are characterised by measuring their electrical properties as a function of external stimuli. In particular, their responses to vapours of toluene, methanol and dioxan are investigated. As studied, the PEO/MWNT material shows high and stable sensitivity over three testing cycles for the selected vapours. An increase in electrical resistance is observed under the influence of chemical substances. This paper supports the concept that penetration of molecules of selected chemical substances leads to the partial disorder of contact between neighboured nanotubes located in the polymer matrix. The electro-spun non-woven fabric with a low amount of MWNT (3 wt.%) in the PEO matrix seems to be a good textile product for application a.
Using the ADDIE model to develop online continuing education courses on caring for nurses in Taiwan.

BACKGROUND A hospital in Taiwan committed to implementing a framework of caring in clinical practice. This study was conducted to develop online courses on caring for the hospital's nurses. METHOD The ADDIE (Analysis, Design, Development, Implementation, and Evaluation) model was applied to develop and evaluate this caring curriculum. Concrete caring and uncaring behaviors were identified through patient and nurse interviews. These were used to make 72 instructional videos and five live-action movies. Evaluation tools included quizzes, self-evaluations, focus group interviews, and a measurement of caring behavior. Patients used the same instrument to evaluate the nurses. RESULTS Nurses' self-evaluations showed positive results. No significant difference was found between pre- and postcourse patient evaluations. CONCLUSION This study shows the usefulness of ADDIE and provides a model for how research data and results can be used to inform administratively mandated organizational change. It also provides evidence on the effects of caring education.
Viral Hepatitis Strategic Information to Achieve Elimination by 2030: Key Elements for HIV Program Managers

Evidence documenting the global burden of disease from viral hepatitis was essential for the World Health Assembly to endorse the first Global Health Sector Strategy (GHSS) on viral hepatitis in May 2016. The GHSS on viral hepatitis proposes to eliminate viral hepatitis as a public health threat by 2030. The GHSS on viral hepatitis is in line with targets for HIV infection and tuberculosis as part of the Sustainable Development Goals. As coordination between hepatitis and HIV programs aims to optimize the use of resources, guidance is also needed to align the strategic information components of the 2 programs. The World Health Organization monitoring and evaluation framework for viral hepatitis B and C follows an approach similar to the one of HIV, including components on the following: (1) context (prevalence of infection), (2) input, (3) output and outcome, including the cascade of prevention and treatment, and (4) impact (incidence and mortality). Data systems that are needed to inform this framework include (1) surveillance for acute hepatitis, chronic infections, and sequelae and (2) program data documenting prevention and treatment, which for the latter includes a database of patients. Overall, the commonalities between HIV and hepatitis at the strategic, policy, technical, and implementation levels justify coordination, strategic linkage, or integration, depending on the type of HIV and viral hepatitis epidemics. Strategic information is a critical area of this alignment under the principle of what gets measured gets done. It is facilitated because the monitoring and evaluation frameworks for HIV and viral hepatitis were constructed using a similar approach. However, for areas where elimination of viral hepatitis requires data that cannot be collected through the HIV program, collaborations are needed with immunization, communicable disease control, tuberculosis, and hepatology centers to ensure collection of information for the remaining indicators.