Miracle-dz/UniFAR-FTUs huggingface dataset:
OMNeT++ and mosaik: Enabling Simulation of Smart Grid Communications

This paper presents a preliminary system architecture of integrating OMNeT++ into the mosaik co-simulation framework. This will enable realistic simulation of communication network protocols and services for smart grid scenarios and on the other side, further development of communication protocols for smart grid applications. Thus, by integrating OMNeT++ and mosaik, both communities will be able to leverage each others's sophisticated simulation models and expertise. The main challenges identified are the external management of the OMNeT++ simulation kernel and performance issues when federating various simulators, including OMNeT++ into the mosaik framework. The purpose of this paper is to bring these challenges up and to gather relevant experience and expertise from the OMNeT++ community. We especially encourage collaboration among all OMNeT++ developers and users.
Title Scenario-based real-time demand response considering windpower and price uncertainty

Real-time pricing can potentially lead to economic advantages for consumers in the environment of smart grid. Compared with flat rates, dynamic pricing allows consumers more engagement through measures of demand response (DR). This paper investigated the optimal hourly electricity consumption scheduling problem of a given consumer responding real-time price. The objective of the proposed model is to maximize the surplus of a consumer that is equipped with wind power and storage devices. Hourly utility curve is considered as a function of power consumption. Bidirectional communication between the consumer and the supplier allows for interval price updates, so the consumer can flexibly adjust hourly demand. Key sources influencing final performance are price uncertainty and renewable power generation uncertainty. Uncertainties are modelled via scenario-based stochastic optimization, where its feasibility is illustrated in numerical simulations.
Algorithm 1 “ Smoothing ” Secondary Structure Element Sequence Input : Secondary Structures over a Protein Sequence Output : Smoothed Secondary Structure Element Sequence Initialize : MeaningfulMinLength as 3 for Coil and 5 for Sheet and Helix Initialize : MaxGroupLength

For the labeled data, we chose the half maximal inhibitory concentration (IC50) as the main measure of binding affinity and extracted samples with known IC50 values from BindingDB (Liu et al., 2006). We used the measurements along with amino-acid sequences of proteins and 2D structures of compounds provided by BindingDB in the file “BindingDB All 2018m8.tsv. zip”. Since compound SMILES strings are not always available and not necessarily in the canonical form, we retrieved these strings from PubChem (Kim et al., 2016) by cross-referencing their PubChem CIDs (compound IDs). As 95% of compounds and proteins with known IC50 values are of lengths up to 100 (SMILES characters) and 1500 (amino acids), respectively, we removed samples outside of the length ranges. And we also removed samples with incomplete information to determine protein sequences (such as those containing the letter “X”, lower-case letters, or arabic numerals) or with IC50 as a range instead of exact value (unless it is worse than a weak 10−2M (10mM) or better than a tight 10−11M (0.01nM)). Moreover, for each protein-compound pairs with multiple measurements, we removed measurements outside aforementioned ranges and then used the geometric mean of the rest. In the end, we collected 489,280 IC50 samples from BindingDB. The collected IC50 data are split into training, testing, and 4 generalization sets. We first withheld 4 generalization sets of all the 3,374 nuclear estrogen receptors (ER α and β), 14,599 ion channels, 34,318 receptor tyrosine kinases, and 60,238 G-protein coupled receptors (GPCR), respectively; and then split the remaining into the training (263,583) and the testing (113,168) sets. To determine each of the 4 generalization sets (protein classes), we compared each protein’s Gene Ontology (GO) molecular function terms to a set of target GO terms. Specifically, using the QuickGO REST API, we identified for each of the 4 protein classes a target GO molecular function term (ER: GO:0030284, ion channel: GO:0005216, receptor tyrosine kinase: GO:0004713,
Corruption and Education: Empirical Evidence

Corruption is widely believed to be detrimental to economic performance. However, little empirical evidence has been presented to assess its consequences on education.Using various education indicators, this paper aims to examine the effects of corruption on education both from a quantitative and qualitative point of view. The cross - country regression analysis shows a strong link between corruption and secondary school enrollment rates, but the relationship between corruption and education quality as measured by repeater rates is weaker. The results suggest that high and ris ing corruption decreases significantly access to schooling. A unit increase in corruption reduces enrollment rates by almost 10 percentage points. These findings are robust to the use of alternative measure of corruption and other sensitivity analysis.
Local Arp2/3-dependent actin assembly modulates applied traction force during apCAM adhesion site maturation

In growth cones, local Arp 2/3-dependent actin assembly mechanically buffers apCAM adhesions from retrograde flow–associated traction forces. The resulting propulsive forces drive the exploratory motility of inductopodia. Increasing the stiffness of apCAM targets induces an extensive 3D actin cup to form at the adhesion during evoked growth responses.
The Monotonic Diameter of the Perfect 2-matching Polytope

The monotonic diameter of the perfect 2-matching polytope associated to the complete graph with n nodes is shown to be $[ n/2 ]$ for all $n \geq 3$, except for $n = 3,4,8$, and 9, in which case the monotonic diameter is $[ n/2 ] - 1$. The result establishes the monotonic Hirsch conjecture for this polytope.
The systematic application of the apprenticeship learning pedagogy to computer tutorial design

Describes the Collaborative Apprenticeship Learning Object Toolkit (CALOT), an architecture that forms the basis of a family of tutoring systems. It utilizes the apprenticeship model of learning for the study of operational procedures where theory and practice are both important. Systems built upon the CALOT architecture can be utilized by multiple, non-colocated students in a synchronous manner. A distributed set of students can collaborate on the tutorial in real-time. The development of this type of computer tutorial system is driven by the goal of linking theoretical knowledge with practical operational experience. Active, exploratory, apprentice-style learning is supported via modes of operation within the system. The student can flexibly choose to observe the expert perform and explain operational steps, or to act as an apprentice and carry out the steps autonomously. The student can switch between these modes at their discretion, giving the student control of the level of intervention by the system. Furthermore, the student can explore and reflect on an information space of object designations, procedures and related concepts. Two examples tutorials based on the CALOT architecture are the Collaborative Virtual Spectrometer and the Virtual X-Ray Diffractometer, which teach about NMR spectroscopy and X-ray diffraction, respectively. Finally, BAUEN (Basic AUthoring ENvironment) is a GUI system that helps the software developer designer author a CALOT-based computer tutorial system with maximum efficiency, focusing the developer's efforts on domain content, and not on the system implementation.
Using Radiating Near Field Region to Sample Radiation of Microstrip Traces for Far Field Prediction by Genetic Algorithms

Regarding a microstrip trace above an infinite ground plane, near field and far field regions are clearly defined for near field-far field conversion. Near field radiation data sampled in radiating near field and reactive near field regions are compared for far field prediction. An equivalent set of dipoles are searched by genetic algorithms to approximate the near field data, and then predict the far field. Magnetic near field peak magnitudes are obtained by a method-of-moments simulation, and far field prediction is compared with simulated data.
Modulation of Vitamin D Status and Dietary Calcium Affects Bone Mineral Density and Mineral Metabolism in Göttingen Minipigs

Calcium and vitamin D deficiency impairs bone health and may cause rickets in children and osteomalacia in adults. Large animal models are useful to study experimental osteopathies and associated metabolic changes. We intended to modulate vitamin D status and induce nutritional osteomalacia in minipigs. The control group (n = 9) was fed a semisynthetic reference diet with 6 g calcium and 6,500 IU vitamin D3/kg and the experimental group (n = 10) the same diet but with only 2 g calcium/kg and without vitamin D. After 15 months, the deficient animals were in negative calcium balance, having lost bone mineral density significantly (means ± SEM) with −51.2 ± 14.7 mg/cm3 in contrast to controls (−2.3 ± 11.8 mg/cm3), whose calcium balance remained positive. Their osteoid surface was significantly higher, typical of osteomalacia. Their plasma 25(OH)D dropped significantly from 60.1 ± 11.4 nmol/L to 15.3 ± 3.4 nmol/L within 10 months, whereas that of the control group on the reference diet rose. Urinary phosphorus excretion and plasma 1,25-dihydroxyvitamin D concentrations were significantly higher and final plasma calcium significantly lower than in controls. We conclude that the minipig is a promising large animal model to induce nutritional osteomalacia and to study the time course of hypovitaminosis D and associated functional effects.
The strategies of economic research - An empirical study

The paper analyzes the structure of strategies of economic research on a sample of all regular research papers in 10 general interest journals every 5th year from 1997 to 2017. It is 3,415 papers, with an annual upward trend of 3.3%. I have classified the papers into eight categories: The fraction in theory and empirics are almost equal large. Most empiric papers use the classic strategy, which derives an operational model from theory and run regressions. Several trends are highly significant - notably two main ones: The fraction of theoretical papers has fallen by 26 pp (percentage points), while the fraction of papers using the classic strategy has increased by 15 pp. Many papers using the classic strategy have been analyzed using meta-analysis, which show that the typical paper exaggerate the results reported substantially. There is no reason to believe that other strategies have smaller problems.
Phylogeny of gregarines (Apicomplexa) as inferred from small-subunit rDNA and beta-tubulin.

Gregarines are thought to be deep-branching apicomplexans. Accordingly, a robust inference of gregarine phylogeny is crucial to any interpretation of apicomplexan evolution, but molecular sequences from gregarines are restricted to a small number of small-subunit (SSU) rDNA sequences from derived taxa. This work examines the usefulness of SSU rDNA and beta-tubulin sequences for inferring gregarine phylogeny. SSU rRNA genes from Lecudina (Mingazzini) sp. , Monocystis agilis Stein, Leidyana migrator Clopton and Gregarina polymorpha Dufour, as well as the beta-tubulin gene from Leidyana migrator, were sequenced. The results of phylogenetic analyses of alveolate taxa using both genes were consistent with an early origin of gregarines and the putative 'sister' relationship between gregarines and Cryptosporidium, but neither phylogeny was strongly supported. In addition, two SSU rDNA sequences from unidentified marine eukaryotes were found to branch among the gregarines: one was a sequence derived from the haemolymph parasite of the giant clam, Tridacna crocea, and the other was a sequence misattributed to the foraminiferan Ammonium beccarii. In all of our analyses, the SSU rDNA sequence from Colpodella sp. clustered weakly with the apicomplexans, which is consistent with ultrastructural data. Altogether, the exact position of gregarines with respect to Cryptosporidium and other apicomplexans remains to be confirmed, but the congruence of SSU rDNA and beta-tubulin trees with one another and with morphological data does suggest that further sampling of molecular data will eventually put gregarine diversity into a phylogenetic context.
On the effectiveness of force application in guided leg movements.

In guided leg movements (e.g., in cycling or wheelchair propulsion), the kinematics of a limb are determined by the object on which a force is applied. As a consequence, the force direction can vary and may deviate from the movement direction, that is, the effective direction. In the present study, the relation of effective force application and maximal power output was examined. Subjects (n = 5) performed guided leg tasks on a special dynamometer. They were instructed to exert a maximal force against a moving forceplate in the direction of the movement, as if they were pushing the plate away. Three different movement directions were tested: perpendicular to the horizontal, rotated 30 degrees backward, and rotated 30 degrees forward. For each trial, force and position data were recorded. The results of the experiments showed that in the extreme movement directions (both 30 degrees conditions), the force vector deviated significantly from the direction of the movement. Apparently, maximal power output was achieved with a low force effectiveness in these tasks. The background of this phenomenon was revealed by using the kinematics of one of these tasks in a simulation model. The stimulation level of 6 leg muscles was optimized toward a maximal effective force component (a) without a constraint on the direction of the total force or (b) with a constraint on the force component perpendicular to the effective force. The muscle stimulation pattern that resulted in the highest effective force coincided with a low force effectiveness. Apparently, this is a prerequisite for maximal power transfer from the muscles to the plate in these guided movements.
Bottom up approaches to defining future climatemitigation commitments

Dit rapport beschrijft de resultaten van een aantal in de literatuur geopperde alternatieve, bottom-up benaderingen om verplichtingen vorm te geven,i.e. technologie en performance standaards, technologie onderzoek en ontwikkelingsafspraken, sectorale verplichtingen, S-CDM (Sectoraal CDM) en SD-PAMs (Sustainable Development Policies & Measures), en analyseert de sterke en zwakke punten van de benaderingen. Daarnaast analyseert dit rapport in meer detail een bottom-up benadering voor de definitie van nationale emissie doelstellingen, de zogenaamde mondiale Triptych approach, en vergelijkt deze benadering met meer top-down benaderingen (Multi-stage (MS) en Contraction and Convergence(C&C)) op basis van een kwantitatieve en kwalitatieve analyse. Dit leidt tot de conclusie dat bottom-up benaderingen waardevolle componenten kunnen zijn van een toekomstig klimaatregime, maar dat ze geen volledig of volwaardig alternatief kunnen vormen voor kwantitatieve verplichtingen (emissieplafonds), daar ze minder zekerheid geven over de milieueffectiviteit van klimaatbeleid. In vergelijking met Multi-stage en de C&C top-down benaderingen biedt de mondiale Triptych benadering de mogelijkheid van vroege deelname van de ontwikkelingslanden zonder het risico van "hot air", zoals onder C&C, en vermijdt de noodzaak om de niet-Annex I op te splitsen zoals bij Multi-Stage. Echter, door de complexiteit en data-intensiviteit van de Triptych benadering zijn er substantikle implementatieproblemen te verwachten in de minst ontwikkelde ontwikkelingslanden als het gevolg van hun gebrekkige institutionele en technische capaciteiten. Het lijkt beter om deze landen in eerste instantie uit te sluiten, en hun te enthousiasmeren voor het op zich nemen van niet-bindende kwantitatieve verplichtingen.
Regional innovation patterns and the EU regional policy reform: towards smart innovation policies

The present debate on regional policy design to fit the Europe 2020 Agenda calls for additional reflections on the way sectoral policies, like innovation policies, can be translated appropriately into a regional setting. The paper enters the debate on smart specialization strategies by stressing the need to overcome the simplistic dichotomy between core and periphery in the Union, between an advanced ‘research area’ (the core) and a ‘co-application area’ of general purpose technologies to local technological specificities (the periphery). The geography of innovation is much more complex than a simple core-periphery model, and the logical pathway towards innovation is much more complex than the linear model of R&D-invention-innovation direct link: the innovation patterns are differentiated among regions, according to their regional context conditions. The identification of specific ‘innovation patterns’ is necessary to design ‘smart innovation’ policies. The paper presents a critic to the smart specialization debate, suggests a new taxonomy of European innovative regions based on their innovation patterns, and proposes innovation policies for each regional mode of innovation.
Multi-polarized multi-user Massive MIMO: Precoder design and performance analysis

Space limitation and multi-antenna channel acquisition prevent Massive multiple-input multiple-output (MIMO) from being easily deployed. The use of multi-polarized antennas can be one solution to alleviate the first obstacle. Furthermore, the dual structured precoding, in which a preprocessing based on the spatial correlation and a subsequent linear precoding based on the short-term channel state information at the transmitter (CSIT) are concatenated, can reduce the feedback overhead efficiently. To reduce the feedback overhead further, we propose a dual structured multi-user linear precoding, in which the subgrouping method based on co-polarization is additionally applied to the spatially grouped mobile stations (MSs) in the preprocessing stage. By investigating the behavior of the asymptotic performance as a function of the cross-polar discrimination (XPD) parameter, we also propose a new dual structured precoding, in which the XPD, spatial correlation, and CSIT quality are jointly utilized in the precoding/feedback for the multi-polarized multi-user massive MIMO system.
Title Effects of adrenomedullin on the expression of inflammatory cytokines and chemokines in oviducts from women with tubal ectopic pregnancy : an in-vitro experimental study

Background: The occurrence of tubal ectopic pregnancy (tEP) is related to the inflammation of the oviduct. Recently, Adrenomedullin (ADM) was found highly expression in human oviduct. The current study is to investigate whether ADM have a modulatory action on inflammatory cytokines and chemokines in oviductal tissue from women with tubal ectopic pregnancy (tEP). Methods: Oviductal isthmus samples were collected from women with tEP undergoing salpingectomy, and women undergoing hysterectomy for benign gynaecological conditions. The mRNA and protein levels of inflammatory cytokines/chemokines were assayed by PCR (n = 6 for tEP, n = 5 for controls) and protein microarray methods (n = 5 for both tEP and controls) respectively. Results: Some of the inflammatory cytokines/chemokines were upregulated by ADM in oviducts from tEP patients at both mRNA and protein levels. Incubation of oviduct from tEP patients with ADM for 24 h down-regulated some of these cytokines/chemokines. Conclusion: Our results suggest an additional mechanism whereby ADM insufficiency may increase the susceptibility to tEP through diminished anti-inflammatory activity. The actual impact of the relationship between ADM and inflammatory process on tubal implantation needs further exploration.
Temperament and stress coping styles in bronchial asthma patients

Introduction Temperament, defined as the formal characteristics of behavior, is a personality trait which can influence the clinical presentation and course of bronchial asthma. It determines susceptibility to stress as well as stress coping styles. Aim The aim of the study was to assess whether healthy subjects differ from bronchial asthma patients with regard to temperamental variables and stress coping styles, and whether these factors may also differentiate patients with severe asthma from those with the milder form. The study also assesses whether the results of flow volume curve analysis correlate with temperamental traits and stress coping styles. Material and methods The study was conducted in a group of 65 asthma patients and 62 healthy controls. All underwent flow volume curve examination and psychological tests: Formal Characteristics of Behavior – Temperament Inventory (FCB-TI) and Coping in Stress Situations (CISS) questionnaire. Results Bronchial asthma patients were characterized by a lower level of briskness (“agility”) than healthy subjects (13.35 ±4.48 vs. 14.97 ±3.98, p = 0.031). The remaining temperamental traits and stress coping styles did not differ between the groups. Additionally, the forced expiratory volume in 1 s (FEV1) value was found to correlate negatively with the intensity of the emotion-oriented stress coping style, whereas FEV1 and forced vital capacity (FVC) were found to positively correlate with briskness, emotional reactivity and endurance, while a negative correlation was found with activity. Conclusions Briskness differentiates healthy subjects from bronchial asthma patients. The values obtained in FEV1 and FVC pulmonary function tests were also found to correlate with some temperamental variables.
ibifolin , a flavonol glycoside , prevents-amyloid-induced neurotoxicity in ultured cortical neurons

The toxicity of aggregated -amyloid (A ) has been implicated as a critical cause in the development of Alzheimer’s disease (AD). Hibifolin, a flavonol glycoside derived from herbal plants, possessed a strong protective activity against cell death induced by aggregated A . Application of hibifolin in primary cortical neurons prevented the A -induced cell death in a dose-dependent manner. In cultured cortical neurons,
Problem Video Gaming Among Children Enrolled in Tertiary Weight Management Programs

Prior studies show seven percent to nine percent of children demonstrate gaming behaviors that affect a child's ability to function (e.g., problem gaming), but none have examined the association between problem gaming and weight status. The objective of this study was to determine the prevalence of problem gaming among children enrolled in tertiary weight management programs. We administered a computer-based survey to a convenience sample of children aged 11-17 years enrolled in five geographically diverse pediatric weight management (PWM) programs in the COMPASS (Childhood Obesity Multi-Program Analysis and Study System) network. The survey included demographics, gaming characteristics, and a problem gaming assessment. The survey had 454 respondents representing a diverse cohort (53 percent females, 27 percent black, 24 percent Hispanic, 41 percent white) with mean age of 13.7 years. A total of 8.2 percent of respondents met criteria for problem gaming. Problem gamers were more likely to be white, male, play mature-rated games, and report daily play. Children in PWM programs reported problem gaming at the same rate as other pediatric populations. Screening for problem gaming provides an opportunity for pediatricians to address gaming behaviors that may affect the health of children with obesity who already are at risk for worsened health and quality of life.
Intermittent versus on‐demand use of a very low calorie diet: a randomized 2‐year clinical trial

Abstract. Lantz H, Peltonen M, Ågren L, Torgerson JS (Sahlgrenska University Hospital, Göteborg, Sweden). Intermittent versus on‐demand use of a very low calorie diet: a randomized 2‐year clinical trial. J Intern Med 2003; 253: 463–471.