Miracle-dz/UniFAR-FTUs huggingface dataset:
Figure–ground discrimination behavior in Drosophila. I. Spatial organization of wing-steering responses

The behavioral algorithms and neural subsystems for visual figure–ground discrimination are not sufficiently described in any model system. The fly visual system shares structural and functional similarity with that of vertebrates and, like vertebrates, flies robustly track visual figures in the face of ground motion. This computation is crucial for animals that pursue salient objects under the high performance requirements imposed by flight behavior. Flies smoothly track small objects and use wide-field optic flow to maintain flight-stabilizing optomotor reflexes. The spatial and temporal properties of visual figure tracking and wide-field stabilization have been characterized in flies, but how the two systems interact spatially to allow flies to actively track figures against a moving ground has not. We took a systems identification approach in flying Drosophila and measured wing-steering responses to velocity impulses of figure and ground motion independently. We constructed a spatiotemporal action field (STAF) – the behavioral analog of a spatiotemporal receptive field – revealing how the behavioral impulse responses to figure tracking and concurrent ground stabilization vary for figure motion centered at each location across the visual azimuth. The figure tracking and ground stabilization STAFs show distinct spatial tuning and temporal dynamics, confirming the independence of the two systems. When the figure tracking system is activated by a narrow vertical bar moving within the frontal field of view, ground motion is essentially ignored despite comprising over 90% of the total visual input.
Sum of us: strategyproof selection from the selectors

We consider the special case of approval voting when the set of agents and the set of alternatives coincide. This captures situations in which the members of an organization want to elect a president or a committee from their ranks, as well as a variety of problems in networked environments, for example in internet search, social networks like Twitter, or reputation systems like Epinions. More precisely, we look at a setting where each member of a set of n agents approves or disapproves of any other member of the set and we want to select a subset of k agents, for a given value of k, in a strategyproof and approximately efficient way. Here, strategyproofness means that no agent can improve its own chances of being selected by changing the set of other agents it approves. A mechanism is said to provide an approximation ratio of α for some α ≥ 1 if the ratio between the sum of approval scores of any set of size k and that of the set selected by the mechanism is always at most α. We show that for k ∈ {1, 2,. , n − 1}, no deterministic strategyproof mechanism can provide a finite approximation ratio. We then present a randomized strategyproof mechanism that provides an approximation ratio that is bounded from above by four for any value of k, and approaches one as k grows.
Identification and Function of Exchange Proteins Activated Directly by Cyclic AMP (Epac) in Mammalian Spermatozoa

The role of cAMP in spermatic functions was classically thought to be mediated exclusively through the activation of Protein Kinase A (PKA). However, it has recently been shown that cAMP also exerts its effects through a PKA-independent pathway activating a family of proteins known as Epac proteins. Therefore, many of the spermatic functions thought to be regulated by cAMP through the activation of PKA are again under study. We aimed to identify and to investigate the role of Epac proteins in spermatozoa using a specific permeable analog (8-Br-2′-O-Me-cAMP). Also, we aimed to study its relationship with E-cadherin, an adhesion protein involved in fertility. Our results demonstrate the presence and sub-cellular distribution of Epac 1 and Epac 2 in mammalian spermatozoa. Capacitation and the acrosome reaction induced a change in the localization of Epac proteins in sperm. Moreover, incubation with 8-Br-2′-O-Me-cAMP prompted an increase in Rap1 activation, in the scrambling of plasma membrane phospholipids (necessary for the capacitation process), the acrosome reaction, motility, and calcium mobilization, when spermatozoa were incubated in acrosome reaction conditions. Finally, the activation of Epac proteins induced a change in the distribution of E-cadherin. Therefore, the increase in the acrosome reaction, together with the increase in calcium (which is known to be essential for fertilization) and the Epac nteraction with E-cadherin, might indicate that Epac proteins have an important role in gamete recognition and fertilization.
A survey of view selection methods

Materialized view selection is a critical problem in many applications such as query processing, data warehousing, distributed and semantic web databases, etc. We refer to the problem of selecting an appropriate set of materialized views as the view selection problem. Many different view selection methods have been proposed in the literature to address this issue. The present paper provides a survey of view selection methods. It defines a framework for highlighting the view selection problem by identifying the main dimensions that are the basis in the classification of view selection methods. Based on this classification, this study reviews most of the view selection methods by identifying respective potentials and limits.
Bicarbonate Uptake by Nitrifiers: Effects of Growth Rate, pH, Substrate Concentration, and Metabolic Inhibitors

The ratios of bicarbonate uptake to substrate oxidation were measured for three genera of nitrifying bacteria. The ratios for the two ammonium oxidizers tested were essentially the same; 0.0863 � 0.0055 and 0.0868 � 0.0091 μmol of bicarbonate were taken up per umol ammonium oxidized for Nitrosomonas europaea and a Nitrosospira strain, respectively. For Nitrobacter sp. , a ratio of 0.0236 � 0.0013 μmol of bicarbonate taken up per umol of nitrite oxidized was obtained. Cells were grown in substrate-limited continuous culture and in batch culture, with generation times ranging between 16 and 189 h for the ammonium oxidizers and 18 and 69 h for Nitrobacter sp. All ratios appeared to be independent of growth rates and pH. However, short-term changes in substrate concentration and certain metabolic inhibitors significantly changed the efficiency of bicarbonate uptake. The significance of these results to the application of the nitrapyrin-sensitive bicarbonate uptake method for measuring nitrification rates in natural samples is discussed.
Adherent-invasive Escherichia coli Exacerbates Antibiotic-associated Intestinal Dysbiosis and Neutrophil Extracellular Trap Activation

Background:Antibiotic-associated disruption of the gut microbiota is a known risk factor for Crohn's disease. This chronic inflammatory disorder results from aberrant host immune responses to subsets of the gut microbiota, and is characterized by intense neutrophil recruitment to the lamina propria, surface and crypt epithelium. Importantly, adherent-invasive Escherichia coli (AIEC) is abundant in ileal biopsies, highlighting a possible etiological role. In this study, we investigated the impact of antibiotics and AIEC challenge on murine intestinal dysbiosis and neutrophil extracellular trap activation, which is a critical component of the neutrophil antimicrobial repertoire. Methods:Male C57BL/6 mice were administered vancomycin and gentamicin (once daily, 3 days), and subsequently challenged with AIEC strain LF82 (once daily, 2 days). Perturbation of the gut microbiota was monitored using a combination of molecular and phylogenetic analyses. The impact of commensal and dysbiotic gut bacterial communities on neutrophil extracellular trap mobilization and intestinal redox balance was also quantified. Results:Exposure of neutrophils to murine commensal gut microbial communities activated neutrophil extracellular trap formation. The capacity of neutrophils to cast these web-like structures was exacerbated following antibiotic and AIEC-associated intestinal dysbiosis, highlighting the possible overgrowth of immune-activating intestinal pathobionts. Intestinal dysbiosis was associated with an elevated capacity of the cultivated gut bacteria to produce reactive oxygen species in vitro, and increased colonic oxidative stress in vivo. Conclusions:Together, these data provide new insights into the detrimental effects of antibiotics on the gut microbiota, with clinically relevant implications for intestinal dysbiosis on neutrophil function and intestinal redox balance.
Enhanced-Boost Quasi-Z-Source Inverters With Two-Switched Impedance Networks

In this paper, two topologies are presented for the enhanced-boost quasi-Z-source inverters (qZSI), namely continuous input current configuration and discontinuous input current configuration of enhanced-boost qZSI with two-switched impedance networks. Similar to enhanced-boost impedance-source inverters (ZSIs), these proposed inverter topologies possess very high boost voltage inversion at low shoot-through duty ratio and high modulation index to provide an improved quality output voltage. Compared to enhanced-boost ZSIs with two-switched Z-source impedance networks, these proposed inverter topologies share common ground with source and bridge inverter, overcome the starting inrush problem, and draw continuous input current and the lower voltage across the capacitors. Moreover, the input ripple current is negligible. This paper presents the operating principles and analysis of continuous input current configuration enhanced-boost qZSI with two-switched impedance networks and compares with ZSI, switched inductor ZSI, DA/CA-qZSI, and enhanced-boost ZSIs. The theoretical analysis is done and is validated through simulation and experimental results.
Electrochemical deposition of mesoporous NiCo2O4 nanosheets on Ni foam as high-performance electrodes for supercapacitors

Abstract The ultrathin, ternary nickel cobaltite (NiCo2O4) nanosheets supported on Nickel foam (NF) were prepared via a facile two step process, which includes electrodeposition method combined with a thermal treatment. The scanning electron microscopy (SEM) and transmission electron microscopy (TEM) characterisation of as-prepared material demonstrates the nanostructure grown on Ni foam is consisted of NiCo2O4 layer and NiCo2O4 nanosheets. The as-prepared samples are directly fabricated as electrodes for supercapacitors, and the outstanding electrochemical performance of 2517 F g− 1 is achieved at 1 A g− 1 with a mass loading of 1·2 mg cm− 2.The cyclic stability is also tested under current density of 8 A g− 1, and 64% of initial capacitance is still maintained after 800 cycles. The excellent electrochemical performance of the as-prepared nanosheets suggests their promising application as supercapacitor electrode material.
Motion-Compensated Compression of Dynamic Voxelized Point Clouds

Dynamic point clouds are a potential new frontier in visual communication systems. A few articles have addressed the compression of point clouds, but very few references exist on exploring temporal redundancies. This paper presents a novel motion-compensated approach to encoding dynamic voxelized point clouds at low bit rates. A simple coder breaks the voxelized point cloud at each frame into blocks of voxels. Each block is either encoded in intra-frame mode or is replaced by a motion-compensated version of a block in the previous frame. The decision is optimized in a rate-distortion sense. In this way, both the geometry and the color are encoded with distortion, allowing for reduced bit-rates. In-loop filtering is employed to minimize compression artifacts caused by distortion in the geometry information. Simulations reveal that this simple motion-compensated coder can efficiently extend the compression range of dynamic voxelized point clouds to rates below what intra-frame coding alone can accommodate, trading rate for geometry accuracy.
Freshwater Biogeography and Limnological Evolution of the Tibetan Plateau - Insights from a Plateau-Wide Distributed Gastropod Taxon (Radix spp.)

Background The Tibetan Plateau is not only the highest and largest plateau on earth; it is also home to numerous freshwater lakes potentially harbouring endemic faunal elements. As it remains largely unknown whether these lakes have continuously existed during the Last Glacial Maximum (LGM), questions arise as to whether taxa have been able to exist on the plateau since before the latest Pleistocene, from where and how often the plateau was colonized, and by which mechanisms organisms conquered remote high altitude lentic freshwater systems. In this study, species of the plateau-wide distributed freshwater gastropod genus Radix are used to answer these biogeographical questions. Methodology/Principal Findings Based on a broad spatial sampling of Radix spp. on the Tibetan Plateau, and phylogenetic analyses of mtDNA sequence data, three probably endemic and one widespread major Radix clade could be identified on the plateau. Two of the endemic clades show a remarkably high genetic diversity, indicating a relatively great phylogenetic age. Phylogeographical analyses of individuals belonging to the most widely distributed clade indicate that intra-plateau distribution cannot be explained by drainage-related dispersal alone. Conclusions/Significance Our study reveals that Radix spp. persisted throughout the LGM on the Tibetan Plateau. Therefore, we assume the continuous existence of suitable water bodies during that time. The extant Radix diversity on the plateau might have been caused by multiple colonization events combined with a relatively long intra-plateau evolution. At least one colonization event has a Palaearctic origin. In contrast to freshwater fishes, passive dispersal, probably by water birds, might be an important mechanism for conquering remote areas on the plateau. Patterns found in Radix spp. are shared with some terrestrial plateau taxa, indicating that Radix may be a suitable model taxon for inferring general patterns of biotic origin, dispersal and survival on the Tibetan Plateau.
Dynamics of Action Potential Initiation in the GABAergic Thalamic Reticular Nucleus In Vivo

Understanding the neural mechanisms of action potential generation is critical to establish the way neural circuits generate and coordinate activity. Accordingly, we investigated the dynamics of action potential initiation in the GABAergic thalamic reticular nucleus (TRN) using in vivo intracellular recordings in cats in order to preserve anatomically-intact axo-dendritic distributions and naturally-occurring spatiotemporal patterns of synaptic activity in this structure that regulates the thalamic relay to neocortex. We found a wide operational range of voltage thresholds for action potentials, mostly due to intrinsic voltage-gated conductances and not synaptic activity driven by network oscillations. Varying levels of synchronous synaptic inputs produced fast rates of membrane potential depolarization preceding the action potential onset that were associated with lower thresholds and increased excitability, consistent with TRN neurons performing as coincidence detectors. On the other hand the presence of action potentials preceding any given spike was associated with more depolarized thresholds. The phase-plane trajectory of the action potential showed somato-dendritic propagation, but no obvious axon initial segment component, prominent in other neuronal classes and allegedly responsible for the high onset speed. Overall, our results suggest that TRN neurons could flexibly integrate synaptic inputs to discharge action potentials over wide voltage ranges, and perform as coincidence detectors and temporal integrators, supported by a dynamic action potential threshold.
Energy assessment of floating photovoltaic system

The floating PV system is a new concept in energy technology to meet the energy needs. The proposed work integrates existing land based technology with a newly developed floating PV technology. In photovoltaic system the electrical efficiency decreases with temperature increase. Therefore in order to achieve higher efficiency the PV module has to be cooled by removing the heat in some way. Floating panels are mounted on the high density thermoplastic polyethylene (HDPE) blocks which can float on the water. In this paper the power generation efficiency of floating and land based were analyzed. The objective of the study is to analyze and compare the performance of conventional and floating based PV system. The system is installed with a capacity of 250 W. The system is tested under solar intensity between 125W/m2 to 945W/m2. The Current (I) - Voltage (V) curves and power (P) - Voltage (V) curves of the results were analyzed. The floating system has shown greater generation efficiency as compared to conventional system. The study found that FPV has higher efficiency and total power gain. The FPV system is convenient to rivers, lakes, ponds, water treatments plants etc.
Localization of eosinophil granule major basic protein in human basophils

In experiments using an immunofluorescent method to localize human eosinophil granule major basic protein (MBP) in cells and tissues, a small number of cells stained for MBP that subsequently could not be identified as eosinophils. Because the Charcot-Leyden crystal protein, another eosinophil protein, was recently identified in basophils, we tested whether MBP might also be a constituent of blood basophils. Highly purified, eosinophil-free basophil suspensions were prepared using the fluorescence-activated cell sorter (FACS) to sort basophil- containing mononuclear cell preparations stained with fluorescein- conjugated sheep IgG anti-human IgE antibody. Using these FACS-purified basophils, we found that: (a) enrichment for surface IgE-positive cells (greater than 95% basophils) by FACS also enriched for cells staining for MBP by immunofluorescence; (b) MBP appeared to be localized in the histamine-, heparin-containing granules; (c) significant quantities of MBP were measurable by radioimmunoassay (RIA) in freeze-thaw detergent extracts of purified basophils; and (d) RIA dose-response curves for extracts of purified eosinophils and basophils had identical slopes. The MBP content of basophils from normal individuals averaged 140 ng/10(6) cells, whereas purified eosinophils from normal donors and patients with the hyper-eosinophilic syndrome averaged 4,979 and 824 ng/10(6) cells, respectively. MBP was also detected by immunofluorescence and RIA in cells obtained from a patient with basophil leukemia, although the MBP content for basophil leukemia cells was lower than that for normal basophils. We conclude that basophils contain a protein that is immunochemically indistinguishable from eosinophil granule MBP.
Non-Monotone Adaptive Submodular Maximization

A wide range of AI problems, such as sensor placement, active learning, and network influence maximization, require sequentially selecting elements from a large set with the goal of optimizing the utility of the selected subset. Moreover, each element that is picked may provide stochastic feedback, which can be used to make smarter decisions about future selections. Finding efficient policies for this general class of adaptive optimization problems can be extremely hard. However, when the objective function is adaptive monotone and adaptive submodular, a simple greedy policy attains a 1 - 1/e approximation ratio in terms of expected utility. Unfortunately, many practical objective functions are naturally non-monotone; to our knowledge, no existing policy has provable performance guarantees when the assumption of adaptive monotonicity is lifted. We propose the adaptive random greedy policy for maximizing adaptive submodular functions, and prove that it retains the aforementioned 1 - 1/e approximation ratio for functions that are also adaptive monotone, while it additionally provides a 1/e approximation ratio for nonmonotone adaptive submodular functions. We showcase the benefits of adaptivity on three real-world network data sets using two non-monotone functions, representative of two classes of commonly encountered non-monotone objectives.
Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma

Multiple myeloma (MM) is an incurable plasma cell malignancy in which p53 is rarely mutated. Thus, activation of the p53 pathway by a small molecule inhibitor of the p53-MDM2 interaction, nutlin, in MM cells retaining wild type p53 is an attractive therapeutic strategy. Recently we reported that nutlin plus velcade (a proteasome inhibitor) displayed a synergistic response in MM. However, the mechanism of the p53-mediated apoptosis in MM has not been fully understood. Our data show that nutlin-induced apoptosis correlated with reduction in cell viability, upregulation of p53, p21, and MDM2 protein levels with a simultaneous increase in pro-apoptotic targets PUMA, Bax and Bak, and down-regulation of anti-apoptotic targets Bcl2 and survivin, and activation of caspase in MM cells harboring wild type p53. Nutlin-induced apoptosis was inhibited when activation of caspase was blocked by the caspase inhibitor. Nutlin caused mitochondrial translocation of p53 where it binds with Bcl2, leading to cytochrome C release. Moreover, blocking the transcriptional arm of p53 by the p53-specific transcriptional inhibitor, pifithrin-α, not only inhibited nutlin-induced upregulation of p53-transcriptional targets but also augmented apoptosis in MM cells, suggesting an association of transcription-independent pathway of apoptosis. However, inhibitor of mitochondrial translocation of p53, PFT-µ, did not prevent nutlin-induced apoptosis, suggesting that the p53 transcription-dependent pathway was also operational in nutlin-induced apoptosis in MM. Our study provides the evidence that nutlin-induced apoptosis in MM cells is mediated by transcription-dependent and -independent pathways and supports further clinical evaluation of nutlin as a novel therapeutic agent in MM.
The strength retrogression of special class Portland oilwell cement

Temperatures in excess of 110 oC result in phase transformations of cement, significantly decreasing its compressive strength. This effect is referred to as strength retrogression. It is frequently observed in cement sheaths of heavy oil wells submitted to steam injection. The present study evaluated the mechanical behavior of Special Class Portland Oilwell Cement (SCPOC) slurries containing silica flour to prevent retrogression. A factorial statistical planning was used to assess the effect of the main variables on the mechanical behavior of cement slurries, i.e., mechanical testing temperature (30, 100, 120, 180 and 230 oC); contents of silica flour replacing cement (0-18 and 36%) and curing time for rupture (12 h and 7 days). The results revealed that slurries containing 18% of silica flour tested at 230 oC depicted an increase in compressive strength up to 30% after curing for 12 h and 10% after curing for 7 days, indicating retrogression. On the other hand, testing slurries containing silica flour at temperatures up to 180 oC revealed strength increase of just 10%, suggesting the mechanical stability of the SCPOC, which prevents retrogression. Such behavior was probably related to the relatively low content of C3A and low specific area of the material. Therefore, strength retrogression at typical bottom hole temperatures of up to 180 oC can be controlled by small additions of silica flour, economically contributing to the use of SCPOC cementing.