Miracle-dz/UniFAR-FTUs huggingface dataset:
The existence of eukaryotic ribonucleoprotein consensus sequence-type RNA-binding proteins in a prokaryote, Synechococcus 6301

A group of proteins containing a conserved ribonucleoprotein consensus sequence (RNP-CS)-type RNA-binding domain (CS-RBD) of approximately 80 amino acids is present in eukaryotic cells and binds specifically to a wide variety of RNA molecules. We have isolated 12 kDa single-stranded DNA binding proteins from the unicellular cyanobacterium Synechococcus 6301. The amino-terminal sequence was determined and two distinct genomic clones were isolated from a Synechococcus 6301 genomic library. Sequence analysis revealed that two closely related proteins contain a single CS-RBD of 82 amino acids and are named as 12RNP1 and 12RNP2. Both of the CS-RBDs share the highest amino acid identity with those of chloroplast ribonucleoproteins (40-51%). The 12RNP proteins were expressed in Escherichia coli bearing plasmids encoding glutathione S-transferase/12RNP fusion proteins and subjected to in vitro nucleic acid-binding assay. Both 12RNP1 and 12RNP2 bind to RNA homopolymers poly(U) and poly(G), indicating that they might be RNA-binding proteins. This is the first example of such proteins in prokaryotes. The 12RNP1 and 12RNP2 genes are transcribed as monocistronic mRNAs and the steady-state mRNA level of 12RNP1 is over 20-fold than that of 12RNP2. Due to the easiness of genetic manipulations the cyanobacterium will provide an excellent system to analyze the function of not only cyanobacterial but also plant RNA-binding proteins.
Rotation resistance airborne remote image real time matching algorithm

In allusion to requirement of real time high precision matching of remote image in airborne image aided navigation system rotation resistance airborne remote image real time matching algorithm is put forward to eliminate noise and geometrical aberrance. Because of great information in remote image at first Harris corner detection algorithm is used to extract character point of remote image to increase matching speed, and modified invariant moment is done to correct image distortion caused by different time, different view angel, different sensor and so on; then robust Hausdorff distance is used to realize remote image real time matching to acquire high matching precision, then simulative experiment is done on airborne image acquired by sensor or radar and digital map stored in computer at last. Simulative experiment indicates that image matching rate of rotation resistance algorithm is better than algorithm which is not adopted modified invariant moment, and the algorithm is available and effective.
Fourteen- to 18-Month-Olds Infer Intentions From Intonation: Evidence From Imitation and Looking Time Measures

This thesis's aim was to examine the effect of vocal intonation on mental state understanding. This thesis has found that vocal intonation provides important cues for communicating the intentions of others' to infants. The results indicate that infants rely on intonation when making attributions about other people's goal-directed behaviour. These results were first found using an imitation paradigm and extended and confirmed with a looking time paradigm. The first two experimental chapters of this thesis have shown that the tone of voice is a salient cue to mental states. Infants did not only distinguish between intentional and accidental words such as "Whoops" and "There" but they also made the distinction between intentional and accidental mental states from the intonation alone. A looking time measure has also shown promising results for the same distinction between intentional and accidental mental states. The looking time study has confirmed and extended the findings that we saw through imitation. Infants seemed able to distinguish between an intentional and an accidental intonation and looked longer during scenes where the accidental intonation was paired with the end-result. These findings are the first to report results on the intonation of accidental and intentional mental states. The results of this thesis contribute to the literature concerning intention understanding and they extend our knowledge about intonation and the significant role it plays in infancy.
Model-Based Planning for State-Related Changes to Infrastructure and Software as a Service Instances in Large Data Centers

To deliver 3-tier applications as a Service in the Cloud state-related constraints crossing Infrastructure- and Software as a Service boundaries need to be managed. By automating the lifecycle of applications like databases, load balancers, and web application servers rich SaaS business services can be provided in the Cloud. We propose an object oriented planning approach based on state constraints to plan for changes of SaaS and IaaS components in the Cloud. We evaluate techniques for fast storing and restoring of large object oriented Configuration Management Databases and show that enforcing constraints in a procedural instead of a declarative way offers huge performance improvements. The advantages of our approach lie within the tight integration of the planning algorithm with object oriented models frequently used for Configuration Management Databases. In addition to that, the algorithm scales to a large number of nodes and preserves its runtime even for large, heavily loaded data centers.
Procédés discursifs et rôles sociaux d’élèves en groupes de discussion sur une controverse socio-scientifique

L’etude de questions socio-scientifiques en classe a ete proposee afin de contribuer a la democratisation des sciences. A cette fin, des situations favorisant les pratiques discursives entre eleves ont ete developpees. Nous avons etudie comment des eleves de premiere apprehendent une controverse socio-scientifique actuelle en groupes de discussion. Dans une approche micro-ethnographique, nous avons identifie differents procedes de discussion collective dans les groupes. Les resultats montrent que des facteurs epistemologiques, contextuels, et sociaux influencent l’elaboration de connaissances dans ces situations.
EOPC: A parallel coding algorithm for XOR-based RAID-6 codes

While inheriting from RAID-6 codes protecting data against two simultaneous disk failures, XOR-based RAID-6 codes are low computational complexity due to only using exclusive-or operations to encode and decode, and are extensively studied and employed in practical. But the potential parallelism of these codes have not yet been sufficiently explored. In this paper, we observe that for XOR-based RAID-6 coding procedures, calculations of parity check equations can be decomposed into pre-calculating and recursive resolution phases. Moreover, these pre-calculating phases of equations can execute in parallel to obtain intermediate blocks that are further used to recursively resolve all missing blocks in a specific sequence. Based on this observation, we present a parallel coding algorithm, called EOPC, for XOR-based RAID-6 codes with the z-turn property, where there exists at least one parity check equation having only one unavailable block under their fault tolerance. We further build EOPC based on two representative XOR-based RAID-6 codes-RDP code and P-Code, to evaluate the effectiveness of EOPC. Experiment results show that EOPC approach outperforms the corresponding serialized approach by more than 50% in encoding/ decoding throughput.
Unsupervised anomaly detection system for Nidis-s based on payload and probabilistic suffix trees

Computer Architecture and Technology Dept., University of the Basque Country, Donostia, Spain ABSTRACT Due to the popularity of computer networks, detection of network attacks is a critical aspect of the security of the companies. As a consequence, any complete security package includes a network Intrusion Detection System (nIDS). This work focuses on nIDSs which work by scanning the network traffic. We combined classifiers based on packet header information with a service-independent payload based approach based on Probabilistic Suffix Trees (PST) to increase detection rates in non-flood attacks. This option is efficient since there is not need of payload processing and besides it outperforms systems based on the ad hoc payload processing proposed in kddcup99, detecting efficiently most of the attack types. This leads us to conclude that payload analysis based on PST is an efficient manner, with no service- or port-specific modeling, to detect attacks in network traffic. KEYWORDS Network intrusion detection, outlier detection, payload, probabilistic suffix trees, clustering.
Imitation-based control of automated ore excavator to utilize human operator knowledge of bedrock condition estimation and excavating motion selection

In order to perform productive autonomous excavation of a fragmented rock pile, it is necessary to recognize the condition of the fragmented rock pile and to plan appropriate excavating motion according to the condition of the fragmented rock pile. In this paper, we propose imitation-based motion planning method, and develop a recognizer of rock pile condition and an excavating motion planner. We also develop an 1/10-scale excavation model and conduct excavation experiment. In the experiment, the proposed method works well from the view point of productivity. It is confirmed that the fragmented rock pile condition can be described by its shape and the particle size distribution of its surface. The proposed approach has feasibility in autonomous excavation of the fragmented rock pile. Experimental results also reveal that both the number of learning data and the diversity of learning data are important to realize a high-productive excavation.
Is ablation to termination the best strategy for ablation of persistent atrial fibrillation? Ablation to termination is not the best strategy during ablation.

> “I’ll follow him around the Horn, and around the Norway maelstrom, and around perdition’s flames before I give him up. ” > > -Captain Ahab, Moby Dick > “The mysterious thing you look for your whole life will eventually eat you alive. ” > > -Laurie Anderson on Moby Dick Optimal strategy and end points for ablation of persistent atrial fibrillation (AF) have not been well established. Although antral pulmonary vein isolation (PVI) is often effective for ablation of paroxysmal AF, it is an insufficient stand-alone strategy for many patients with persistent AF. Selection of adjunctive targets and determination of procedural end points are variable and at the discretion of the operator. Several studies suggested that termination of AF should be the procedural end point during ablation in patients with persistent AF, as a higher probability of maintaining sinus rhythm after the ablation was reported, despite a long procedure duration and a high rate of repeat ablation procedures. However, these studies were not consistently reproducible, and conversion usually occurred to an atrial tachycardia rather than sinus rhythm after extensive ablation. In patients with persistent AF, there is insufficient experimental, mechanistic, or clinical evidence to support termination of AF during ablation as a procedural end point. Response by Lim et al on p 980 Rapid and repetitive depolarizations originating within or at the antra of the pulmonary veins (PVs) and the other thoracic veins are the predominant mechanism in the initiation and perpetuation of paroxysmal atrial fibrillation (PAF). 1–3 Antral isolation of PVs and elimination of focal triggers and drivers from other thoracic veins often result in termination and noninducibility of PAF in response to various pharmacological and pacing protocols. Patients with PAF whose AF terminated during ablation and were rendered noninducible, also were more likely to remain in sinus rhythm during long-term clinical follow-up.4 …
The Effects of Attention Allocation on Fear Extinction

The dissertation consists of one experimental study investigating the potential method for improving exposure therapy outcomes for anxiety disorders through the manipulation of attention allocation. If proven effective, these methods can be utilized to optimize exposure therapy for anxiety disorders or be considered as adjunct interventions intended to compliment and enhance exposure therapy. Although the literature on fear conditioning and the literature on selective attention to threat have received wide support and have consequently implicated the treatment of anxiety disorders in their own right, there is very little integration and reconciliation of the two into a more parsimonious, yet comprehensive, theory of anxiety development, maintenance, and treatment. This study attempted to integrate both bodies of work by examining the effect of attention bias modification training upon Pavlovian fear extinction. This study tested the prediction that training attention towards the threat cue (CS+) would facilitate fear extinction; whereas training attention towards the safety cue (CS-) would impair fear extinction. High trait-anxious participants (N=44) were trained to attend towards the threat cue, towards the safety cue, or equally to both cues in a modified dot probe task. Next, transfer of attention processing tendencies was examined in a differential conditioning paradigm across 2 visits. Results indicated participants trained to attend towards the safety cue demonstrated temporary enhancement of extinction performance, but it did not persist through Visit 2. On the other hand, participants trained to attend towards the threat cue demonstrated reduced fear responding on an expectancy measure of conditioning that did not become apparent until Visit 2. These results suggest that attention training towards the threat cue may benefit extinction learning in the long-term and that attention training towards the safety cue may provide short-term relief from fear.
Uncovering Critical Research Agendas for School Psychology: Conceptual Dimensions and Future Directions

Abstract In this article, we consider research agendas that make sense not only for moving the profession forward by yielding unique contributions in the millennium, but that enable school psychologists to enhance outcomes for children and families with greater precision and effectiveness. We specifically examine some research agendas in the areas of diagnosis and assessment, consultation, prevention and intervention, and evaluation of programs/interventions. Following a contextual scope of practice, potential priorities for future research are presented for consideration. We discuss the need for changes both in the focus and framework used to conceptualize and conduct future research. In addition, we recognize that the direction of research must accommodate the needs of the field by embracing a cross-directional design wherein research not only informs practice but wherein practice informs research.
Built-in-chip testing of voltage overshoots in high-speed SoCs

We present a methodology to detect and measure the signal overshoots occurring on the interconnects of high-speed system-on-chips. Overshoots are known to inject hot-carriers into the gate oxide which cause permanent degradation of MOSFET transistor performance over time. We propose a built-in chip mechanism to detect overshoots, collect the occurrence information and scan them out efficiently and inexpensively for built-in self-test, reliability analysis and diagnosis.
A 10 year retrospective survey of cataract surgery and endophthalmitis in a single eye unit: injectable lenses lower the incidence of endophthalmitis

Aim: To study the incidence of endophthalmitis following cataract surgery over a 10 year period, and to examine ways in which this may be related to changes in surgical technique. Methods: All cases of endophthalmitis occurring over a 10 year period within a single ophthalmic unit in the United Kingdom were reviewed, and possible risk factors identified. Results: During the study period, as the technique of extracapsular cataract surgery was replaced by phacoemulsification, there was a commensurate reduction in the incidence of endophthalmitis. Injectable IOLs were associated with the lowest risk of postoperative endophthalmitis (0.028%). Conclusions: Injectable intraocular lenses do not make contact with the ocular surface and this may result in the observed lower rate of endophthalmitis. This, and the ease with which they can be inserted through small incisions, support their use as the first line method of lens insertion.
Automatically Deriving Tectogrammatical Labels from Other Resources: A Comparison of Semantic Labels Across Frameworks

Local semantic labels are relevant to the verb meaning in question, while global semantic labels are relevant across different verbs and verb meanings. We show that global semantic labels from different frameworks are not necessarily compatible and argue that, therefore, corpora should be annotated with local semantic labels and that global semantic labels should then be automatically annotated using framework-specific lexicons.
Sodium Hydrogen Exchangers Contribute to Arenavirus Cell Entry

ABSTRACT Several arenaviruses, chiefly Lassa virus (LASV), cause hemorrhagic fever (HF) disease in humans and pose a great public health concern in the regions in which they are endemic. Moreover, evidence indicates that the worldwide-distributed prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) is a neglected human pathogen of clinical significance. The limited existing armamentarium to combat human-pathogenic arenaviruses underscores the importance of developing novel antiarenaviral drugs, a task that would be facilitated by the identification and characterization of virus-host cell factor interactions that contribute to the arenavirus life cycle. A genome-wide small interfering RNA (siRNA) screen identified sodium hydrogen exchanger 3 (NHE3) as required for efficient multiplication of LCMV in HeLa cells, but the mechanisms by which NHE activity contributed to the life cycle of LCMV remain unknown. Here we show that treatment with the NHE inhibitor 5-(N-ethyl-N-isopropyl) amiloride (EIPA) resulted in a robust inhibition of LCMV multiplication in both rodent (BHK-21) and human (A549) cells. EIPA-mediated inhibition was due not to interference with virus RNA replication, gene expression, or budding but rather to a blockade of virus cell entry. EIPA also inhibited cell entry mediated by the glycoproteins of the HF arenaviruses LASV and Junin virus (JUNV). Pharmacological and genetic studies revealed that cell entry of LCMV in A549 cells depended on actin remodeling and Pak1, suggesting a macropinocytosis-like cell entry pathway. Finally, zoniporide, an NHE inhibitor being explored as a therapeutic agent to treat myocardial infarction, inhibited LCMV propagation in culture cells. Our findings indicate that targeting NHEs could be a novel strategy to combat human-pathogenic arenaviruses.
A new 3-dimensional curvature integral formula for PL-manifolds of non-positive curvature

In this paper, we derive a new curvature integral formula for 3-dimensional piecewise linear manifolds with singularities. Among other things, we also present a sharp isoperimetric inequality for 3-dimensional PL-manifolds of non-positive curvature by using this new curvature integral formula. Let Ω be a smooth compact domain in a smooth Riemannian manifold, and GK∂Ω represent the Gauss-Kronecker curvature (i.e., the determinant of the second fundamental form) of the boundary of Ω, ∂Ω. A well-known Theorem of Chern-Lashof [CL] states that for any compact convex smooth domain Ω in Rn, the total Gauss-Kronecker curvature of its boundary satisfies ∫
Sleep Deprivation in the Dark Period Does Not Impair Memory in OF1 Mice

There is increasing evidence that sleep facilitates memory acquisition and consolidation. Moreover, the sleep-wake history preceding memory acquisition and retention as well as circadian timing may be important. We showed previously that sleep deprivation (SD) following learning in OF1 mice impaired their performance on an object recognition task. The learning task was scheduled at the end of the 12 h dark period and the test 24 h later. To investigate the influence of the prominent circadian sleep-wake distribution typical for rodents, we now scheduled the learning task at the beginning of the dark period. Wakefulness following immediately after the learning task was attained either by gentle interference (SD; n = 20) or by spontaneous wheel running (RW; n = 20). Two control groups were used: one had no RW throughout the experiment (n = 23), while the other group's wheel was blocked immediately after acquisition (n = 16), thereby preventing its use until testing. Recognition memory, defined as the difference in exploration of a novel and of familiar objects, was assessed 24 h later during the test phase. Motor activity and RW use were continuously recorded. Remarkably, performance on the object recognition task was not influenced by the protocols; the waking period following acquisition did not impair memory, independent of the method inducing wakefulness (i.e., sleep deprivation or spontaneous running). Thus, all groups explored the novel object significantly longer than the familiar ones during the test phase. Interestingly, neither the amount of rest lost during the SD interventions nor the amount of rest preceding acquisition influenced performance. However, the total amount of rest obtained by the control and SD mice subjected to acquisition at “dark offset” correlated positively (r = 0.66) with memory at test, while no such relationship occurred in the corresponding groups tested at dark onset. Neither the amount of running nor intermediate rest correlated with performance at test in the RW group. We conclude that interfering with sleep during the dark period does not affect object recognition memory consolidation.
Revisiting music theory : a guide to the practice

Preface Acknowledgements Notes on the Use of this Book part 1: Notation: The Symbols of Music part 2: Melody : Note Following Note part 3: Harmony: Note(s) with Note(s) part 4: Melodies in Harmony part 5: Musical Structures part 6: Appendices Endnotes Index