Miracle-dz/UniFAR-FTUs huggingface dataset:
Haematopoietic stem cell migration to the ischemic damaged kidney is not altered by manipulating the SDF-1/CXCR4-axis

Background. Haematopoietic stem cells (HSC) have been shown to migrate to the ischemic kidney. The factors that regulate the trafficking of HSC to the ischemic damaged kidney are not fully understood. The stromal cell-derived factor-1 (SDF-1)/CXCR4-axis has been identified as the central signalling axis regulating trafficking of HSC to the bone marrow. Therefore, we hypothesized that SDF-1/CXCR4 interactions are implicated in the migration of HSC to the injured kidney. Methods. HSC were isolated from mouse bone marrow and labelled with a cell tracker. Acceptor mice were subjected to unilateral ischemia and received HSC intravenously directly after reperfusion. In addition, in separate groups of acceptor mice, endogenous SDF-1 or HSC-associated CXCR4 was blocked or kidneys were injected with SDF-1. Results. Exogenous HSC could be detected in the tubules and interstitium of the kidney 24 h after ischemic injury. Importantly, the amount of HSC in the ischemic kidney was markedly higher compared to the contralateral kidney. Neutralizing endogenous SDF-1 or HSC-associated CXCR4 did not prevent the migration of HSC. No increase in the number of labelled HSC could be observed after local administration of SDF-1, as was also determined in bilateral kidney ischemia. Conclusion. In conclusion, systemically administered HSC preferentially migrate to the ischemic injured kidney. This migration could not be prevented by blocking the SDF-1/CXCR4-axis or increased after local administration of SDF-1.
A method to derive maps of ionospheric conductances, currents, and convection from the Swarm multisatellite mission

The European Space Agency (ESA) Swarm spacecraft mission is the first multisatellite ionospheric mission with two low‐orbiting spacecraft that are flying in parallel at a distance of ~100–140 km, thus allowing derivation of spatial gradients of ionospheric parameters not only along the orbits but also in the direction perpendicular to them. A third satellite with a higher orbit regularly crosses the paths of the lower spacecraft. Using the Swarm magnetic and electric field instruments, we present a novel technique that allows derivation of two‐dimensional (2‐D) maps of ionospheric conductances, currents, and electric field in the area between the trajectories of the two lower spacecraft, and even to some extent outside of it. This technique is based on Spherical Elementary Current Systems. We present test cases of modeled situations from which we calculate virtual Swarm data and show that the technique is able to reconstruct the model electric field, horizontal currents, and conductances with a very good accuracy. Larger errors arise for the reconstruction of the 2‐D field‐aligned currents (FAC), especially in the area outside of the spacecraft orbits. However, even in this case the general pattern of FAC is recovered, and the magnitudes are valid in an integrated sense. Finally, using an MHD model run, we show how our technique allows estimation of the ionosphere‐magnetosphere coupling parameter K, if conjugate observations of the magnetospheric magnetic and electric field are available. In the case of a magnetospheric multisatellite mission (e.g., the ESA Cluster mission) several K estimates at nearby points can be generated.
FOXC1 Contributes To Microvascular Invasion In Primary Hepatocellular Carcinoma Via Regulating Epithelial-Mesenchymal Transition

The existence of microvascular invasion (MVI) formation is one of the most important risk factors predicting poor outcome in hepatocellular carcinoma (HCC) and its mechanism remains largely unknown. Epithelial-Mesenchymal Transition (EMT) has been suggested to be involved in many steps of the invasion-metastasis cascade. To elucidate the possible contribution of EMT to MVI, we initially evaluated the expression of 8 EMT-related transcription factors (TFs) in HCC patients with or without MVI and found that FOXC1 expression was significantly higher in patients with MVI than those without MVI (P < 0.05). Knockdown of FOXC1 expression in HCC cells resulted in a partial conversion of their EMT progresses, mainly regulating the mesenchymal component. Ectopic expression of snail, twist or TGF-β1 could induce expression of FOXC1, but none of the expression of snail, twist, slug or TGF-β was consistently down-regulated in response to FOXC1 silencing, suggesting FOXC1 might operate the downstream of other EMT regulators. In addition, knockdown of FOXC1 expression led to cytoskeleton modification accompanied by decreased ability of cell proliferation, migration, and invasion. Meanwhile, some matrix metalloproteinases (MMPs) and VEGF-A were also simultaneously down-regulated. Together, our findings demonstrate that FOXC1 is one of candidate predictive markers of MVI, and that inhibition of FOXC1 expression can partially reverse EMT program, offering a potential molecular therapeutic target for reducing tumor metastasis in HCC patients.
Integrating satellite‐remote sensing and geographic information systems technologies in gully erosion research

Abstract Gully erosion still is a poorly understood process. Methods leading to the detection of gullies can therefore contribute substantially to understand these particular erosion processes. Gully feature detection can be regarded as a first step in the explanation and prediction of gully erosion. In this paper, the integration of remote sensing and geographic information system techniques is discussed in terms of its value in the analysis of gully erosion. The knowledge of the interpreter—the application specialist—is considered as crucial in computer‐assisted processing and analysis.
remineralization of eroded enamel by a naF rinse containing a novel calcium phosphate agent in an in situ model: a pilot study

Purpose: An in situ study evaluated the remineralization potential of 225 ppm fluoride (F) rinses with and without a calcium phosphate agent (TCP-Si-Ur) on eroded enamel. Methods: 20 human patients participated in this IRB approved study. Enamel blocks extracted from 20 human molars were assigned to each of the three study phases ( G1 , G2 , G3 ). Each block was eroded using 1% citric acid (pH = 2.5), with a slice cut from each block to establish baseline lesion parameters (ie, integrated mineral loss ∆ Z, and lesion depth LD) using transverse microradiography (TMR). Participants and assigned blocks were randomly divided into three 28-day phases. The blocks were mounted into modified orthodontic brackets and bonded to the buccal surface of one of the subject’s mandibular molars. The appliance remained in the subject’s mouth for 28 days. Prior to each study phase, participants observed a one-week-washout period using a fluoride-free dentifrice. In each phase, participants brushed with the fluoride-free dentifrice for 1 min, followed by one of the following coded treatments: G1: 225 ppm F + 40 ppm TCP-Si-Ur rinse (1 min); G2: 225 ppm F rinse (1 min); G3: no rinse (saliva-only). After each phase, appliances were removed and specimens were analyzed using TMR. Results: TMR data (ie, ∆ Z and LD) revealed all three groups significantly remineralized eroded enamel (paired t -tests, P , 0.001). Net mineralization (% change in ∆ Z, LD) were as follows (mean (std.dev.): G1: 44.1 (22.6), 30.5 (27.0); G2: 30.0 (7.4), 29.4 (10.5); G3: 23.8 (16.4), 25.7 (15.5). Furthermore, G1 was found to cause significantly more remineralization than G2 ( P = 0.039) and G3, ( P = 0.002). Conclusion: Mouthrinse containing 225 ppm F plus TCP-Si-Ur provided significantly greater remineralization relative to 225 ppm F only or saliva alone.
In Utero Exposure to Benzo[a]Pyrene Increases Mutation Burden in the Soma and Sperm of Adult Mice

Background: Mosaicism, the presence of genetically distinct cell populations within an organism, has emerged as an important contributor to disease. Mutational events occurring during embryonic development can cause mosaicism in any tissue, but the influence of environmental factors on levels of mosaicism is unclear. Objectives: We investigated whether in utero exposure to the widespread environmental mutagen benzo[a]pyrene (BaP) has an impact on the burden and distribution of mutations in adult mice. Methods: We used the Muta™Mouse transgenic rodent model to quantify and characterize mutations in the offspring of pregnant mice exposed to BaP during postconception days 7 through 16, covering the major period of organogenesis in mice. Next-generation DNA sequencing was then used to determine the spectrum of mutations induced in adult mice that were exposed to BaP during fetal development. Results: Mutation frequency was significantly increased in the bone marrow, liver, brain, and sperm of first filial generation (F1) males. Developing embryos accumulated more mutations and exhibited higher proportions of mosaicism than exposed adults, particularly in the brain. Decreased sperm count and motility revealed additional negative impacts on the reproductive function of F1 males. Conclusion: In utero exposure to environmental mutagens contributes to somatic and germline mosaicism, permanently affecting both the genetic health of the F1 and the population gene pool. Citation: Meier MJ, O’Brien JM, Beal MA, Allan B, Yauk CL, Marchetti F. 2017. In utero exposure to benzo[a]pyrene increases mutation burden in the soma and sperm of adult mice. Environ Health Perspect 125:82–88; http://dx.doi. org/10.1289/EHP211
Arc and back-arc geochemistry in the southern Kermadec arc-Ngatoro Basin and offshore Taupo Volcanic Zone, SW Pacific

Abstract Back-arc basin basalts from the Ngatoro Basin (the southern end of the Havre Trough) are similar geochemically to, yet subtly distinct from, basalts of the Havre Trough to the north. Whole rock and glass chemistry are consistent with derivation from a fertile mantle source with subsequent evolution by fractionation of olivine (+ Cr-spinel) + plagioclase, and then clinopyroxene. Basalts from the vicinity of Rumble IV seamount at the southern end of the Kermadec island arc, and the eastern Ngatoro rift escarpment, are strongly porphyritic relative to the back-arc basin basalts and show trace element (high LIL abundances and highly depleted HFS abundances) and isotopic signatures of subduction zone basalts. At its southern end, the Ngatoro Basin penetrates the continental crust of New Zealand creating a major, 3000 m deep bathymetric re-entrant in the slope-break; the slope-break marks the transition from oceanic to continental crust. Basalts from the floor of the Ngatoro Basin re-entrant are isotopically distinct from the basalts of the oceanic sector in that they have higher Sr and correspondingly lower Nd isotope ratios and are comparable to basalts of the Taupo Volcanic Zone (TVZ) to the south. In contrast to the basalt-dominated oceanic sector, basalts from the offshore TVZ, a 100 km long area extending roughly NNE from White Island to the submarine Whakatane arc volcano at the edge of the continental slope-break, occur in association with andesites, dacites and rhyolites. These basalts are generally strongly porphyritic (olivine + plagioclase + clinopyroxene) and show trace element abundances typical of suprasubduction zone rocks. However, offshore TVZ basalts show subtle distinctions from onshore TVZ basalts to the south; the former have more radiogenic Sr isotopes. Furthermore, their high field strength element and transition element systematics appear to overlap with those of basalts from the Kermadec arc to the north. The authors attribute these lateral (along arc) and transverse (across arc) variations to source heterogeneity and variable fertility in the sources of the arc and back-arc basin magmas. Sources of the arc-front magmas are more refractory and also more susceptible to contamination by slab-derived fluids than sources for back-arc basin magmatism, reflecting the dynamic nature of flow from the back-arc into the mantle wedge beneath the volcanic front.
Evaluation of Global Monsoon Precipitation Changes based on Five Reanalysis Datasets

AbstractWith the motivation to identify whether a reasonably simulated atmospheric circulation would necessarily lead to a successful reproduction of monsoon precipitation, the performances of five sets of reanalysis data [NCEP–U.S. Department of Energy (DOE) Atmospheric Model Intercomparison Project II (AMIP-II) reanalysis (NCEP-2), 40-yr ECMWF Re-Analysis (ERA-40), Japanese 25-yr Reanalysis Project (JRA-25), Interim ECMWF Re-Analysis (ERA-Interim), and Modern-Era Retrospective Analysis for Research and Applications (MERRA)] in reproducing the climatology, interannual variation, and long-term trend of global monsoon (GM) precipitation are comprehensively evaluated. To better understand the variability and long-term trend of GM precipitation, the authors also examined the major components of water budget, including evaporation, water vapor convergence, and the change in local column water vapor, based on the five reanalysis datasets. Results show that all five reanalysis datasets reasonably reproduce the .
Atmospheric Chemistry Experiment (ACE) observations of aerosol in the upper troposphere and lower stratosphere from the Kasatochi volcanic eruption

[1] Near-infrared (NIR) atmospheric extinction profile observations from the Atmospheric Chemistry Experiment (ACE) Imager and from Measurements of Aerosol Extinction in the Stratosphere and Troposphere Retrieved by Occultation (MAESTRO) are presented, illustrating the impact of the Kasatochi volcanic eruption in August 2008 on the aerosol loading of the upper troposphere and lower stratosphere in the subsequent months. In September 2008, profiles of NIR extinction show a significant increase relative to each of the previous four Septembers (2004–2007). The aerosol enhancement is observable up to 18.5 km in Northern Hemisphere NIR extinction data, and peaks at 9.5 km in the extratropics, where the extinction is ∼8 times the normal September value. The particulate matter in the troposphere is quickly dispersed over the Northern Hemisphere during September 2008 and vanishes by the end of November 2008. An upper layer, initially in the extratropical lower stratosphere, persists through March 2009, descending with time into the troposphere where, by coagulation of sulphate aerosol, the size of the particles increases with time.
Enhanced Photoacoustic Gas Analyser Response Time and Impact on Accuracy at Fast Ventilation Rates during Multiple Breath Washout

Background The Innocor device contains a highly sensitive photoacoustic gas analyser that has been used to perform multiple breath washout (MBW) measurements using very low concentrations of the tracer gas SF6. Use in smaller subjects has been restricted by the requirement for a gas analyser response time of <100 ms, in order to ensure accurate estimation of lung volumes at rapid ventilation rates. Methods A series of previously reported and novel enhancements were made to the gas analyser to produce a clinically practical system with a reduced response time. An enhanced lung model system, capable of delivering highly accurate ventilation rates and volumes, was used to assess in vitro accuracy of functional residual capacity (FRC) volume calculation and the effects of flow and gas signal alignment on this. Results 10–90% rise time was reduced from 154 to 88 ms. In an adult/child lung model, accuracy of volume calculation was −0.9 to 2.9% for all measurements, including those with ventilation rate of 30/min and FRC of 0.5 L; for the un-enhanced system, accuracy deteriorated at higher ventilation rates and smaller FRC. In a separate smaller lung model (ventilation rate 60/min, FRC 250 ml, tidal volume 100 ml), mean accuracy of FRC measurement for the enhanced system was minus 0.95% (range −3.8 to 2.0%). Error sensitivity to flow and gas signal alignment was increased by ventilation rate, smaller FRC and slower analyser response time. Conclusion The Innocor analyser can be enhanced to reliably generate highly accurate FRC measurements down at volumes as low as those simulating infant lung settings. Signal alignment is a critical factor. With these enhancements, the Innocor analyser exceeds key technical component recommendations for MBW apparatus.
Formation Evaluation Using Measurements Recorded While Drilling

Two of the measurements recorded while drilling (MWD), gamma ray and resistivity, are traditionally formation evaluation measurements. However, their primary user thus far has been the drilling engineer. The authors believe that MWD will have increasing importance in formation evaluation, and that a good understanding of MWD resistivity and gamma ray logs will be needed by the log analyst. MWD gamma ray and resistivity logs are similar to their wireline counterparts, but there are significant differences. The differences stem from different invasion (or lack of invasion) development for MWD as opposed to open hole wireline; drill collar influence on both the resistivity and gamma ray (GR) measurements - this influence is both positive and negative; and logging speed (drilling rate for MWD) is much slower for MWD and can vary erratically. The MWD logs presented in this paper demonstrate the value of using MWD logs. Emphasis is placed on both the qualitative and quantitative techniques available to the log analyst to help him get maximum benefit from the MWD logs.
Risks for animal health related to the presence of zearalenone and its modified forms in feed

Abstract Zearalenone (ZEN), a mycotoxin primarily produced by Fusarium fungi, occurs predominantly in cereal grains. The European Commission asked EFSA for a scientific opinion on the risk to animal health related to ZEN and its modified forms in feed. Modified forms of ZEN occurring in feed include phase I metabolites α‐zearalenol (α‐ZEL), β‐zearalenol (β‐ZEL), α‐zearalanol (α‐ZAL), β‐zearalanol (β‐ZAL), zearalanone (ZAN) and phase II conjugates. ZEN has oestrogenic activity and the oestrogenic activity of the modified forms of ZEN differs considerably. For ZEN, the EFSA Panel on Contaminants in the Food Chain (CONTAM) established no observed adverse effect levels (NOAELs) for pig (piglets and gilts), poultry (chicken and fattening turkeys), sheep and fish (extrapolated from carp) and lowest observed effect level (LOAEL) for dogs. No reference points could be established for cattle, ducks, goats, horses, rabbits, mink and cats. For modified forms, no reference points could be established for any animal species and relative potency factors previously established from rodents by the CONTAM Panel in 2016 were used. The dietary exposure was estimated on 17,706 analytical results with high proportions of left‐censored data (ZEN about 60%, ZAN about 70%, others close to 100%). Samples for ZEN were collected between 2001 and 2015 in 25 different European countries, whereas samples for the modified forms were collected mostly between 2013 and 2015 from three Member States. Based on exposure estimates, the risk of adverse health effects of feed containing ZEN was considered extremely low for poultry and low for sheep, dog, pig and fish. The same conclusions also apply to the sum of ZEN and its modified forms.
Technology-Based Interventions for Mental Health in Tertiary Students: Systematic Review

Background Mental disorders are responsible for a high level of disability burden in students attending university. However, many universities have limited resources available to support student mental health. Technology-based interventions may be highly relevant to university populations. Previous reviews have targeted substance use and eating disorders in tertiary students. However, the effectiveness of technology-based interventions for other mental disorders and related issues has not been reviewed. Objective To systematically review published randomized trials of technology-based interventions evaluated in a university setting for disorders other than substance use and eating disorders. Methods The PubMed, PsycInfo, and Cochrane Central Register of Controlled Trials databases were searched using keywords, phrases, and MeSH terms. Retrieved abstracts (n=1618) were double screened and coded. Included studies met the following criteria: (1) the study was a randomized trial or a randomized controlled trial, (2) the sample was composed of students attending a tertiary institution, (3) the intervention was delivered by or accessed using a technological device or process, (4) the age range of the sample was between 18 and 25 years, and (5) the intervention was designed to improve, reduce, or change symptoms relating to a mental disorder. Results A total of 27 studies met inclusion criteria for the present review. Most of the studies (24/27, 89%) employed interventions targeting anxiety symptoms or disorders or stress, although almost one-third (7/24, 29%) targeted both depression and anxiety. There were a total of 51 technology-based interventions employed across the 27 studies. Overall, approximately half (24/51, 47%) were associated with at least 1 significant positive outcome compared with the control at postintervention. However, 29% (15/51) failed to find a significant effect. Effect sizes were calculated for the 18 of 51 interventions that provided sufficient data. Median effect size was 0.54 (range –0.07 to 3.04) for 8 interventions targeting depression and anxiety symptoms and 0.84 (range –0.07 to 2.66) for 10 interventions targeting anxiety symptoms and disorders. Internet-based technology (typically involving cognitive behavioral therapy) was the most commonly employed medium, being employed in 16 of 27 studies and approximately half of the 51 technology-based interventions (25/51, 49%). Distal and universal preventive interventions were the most common type of intervention. Some methodological problems were evident in the studies, with randomization methods either inadequate or inadequately described, few studies specifying a primary outcome, and most of the studies failing to undertake or report appropriate intent-to-treat analyses. Conclusions The findings of this review indicate that although technological interventions targeting certain mental health and related problems offer promise for students in university settings, more high quality trials that fully report randomization methods, outcome data, and data analysis methods are needed.
Nicotine replacement therapies: patient safety and persistence

: Nicotine replacement therapy (NRT) has become a central part of the treatment of nicotine dependence. However, NRT’s potential efficacy is limited to some extent by patient adherence and persistence. Here we review the relationship between NRT compliance and adherence, and overall treatment outcome. We then examine the factors that likely impact on treatment compliance and persistence, with a special focus on users’ perceptions of treatment safety and efficacy as possible mediators. Potential clinical strategies for improving suboptimal medication use are also discussed.