Miracle-dz/UniFAR-FTUs huggingface dataset:
General anesthesia, using remimazolam, for the patient with myelin oligodendrocyte glycoprotein antibody associated disease (MOGAD): A case report

Rationale: Myelin oligodendrocyte glycoprotein antibody associated disease (MOGAD) is one of auto-immune demyelinating diseases of nervous system. Although both regional anesthesia and general anesthesia has been successfully performed in the patient with demyelinating diseases of nervous system, it has been controversial which one is better. Patient concerns: Forty-four male patient was admitted for arthroscopic elbow surgery due to limitation of range of motion. The patient was diagnosed as MOGAD with anti-N-methyl-D-aspartate (NMDA) receptor encephalitis, and steroid was used to prevent and treat symptoms and signs. Diagnosis: He was diagnosed as MOGAD with anti-NMDA receptor encephalitis, 1 year ago. The patient complaint of dizziness, diplopia, nausea, vomiting, seizure, general weakness and so on when he was confirmed as MOGAD with anti-NMDA receptor encephalitis. The diagnosis of MOGAD was confirmed with positive anti-myelin oligodendrocyte glycoprotein (MOG) Immunoglobulin (Ig)G and negative anti-aquaporin 4 (AQP4) IgG in the blood. Interventions and outcomes: After steroid cover, total intravenous anesthesia (TIVA) with remimazolam and remifentanil was established for the patients. Rocuronium was administered under monitoring of neuromuscular blockade, using train of 4 (TOF). The operation was performed without any event under right lateral decubitus position. The patient was uneventfully recovered from anesthesia. Lessons: The case report showed total intravenous anesthesia with remimazolam and remifentanil under proper monitoring was successfully performed in the patient with MOGAD.
Measurement of the response of a Ga solar neutrino experiment to neutrinos from a Ar37 source

An intense source of {sup 37}Ar was produced by the (n,{alpha}) reaction on {sup 40}Ca by irradiating 330 kg of calcium oxide in the fast neutron breeder reactor at Zarechny, Russia. The {sup 37}Ar was released from the solid target by dissolution in acid, collected from this solution, purified, sealed into a small source, and brought to the Baksan Neutrino Observatory where it was used to irradiate 13 tonnes of gallium metal in the Russian-American gallium solar neutrino experiment SAGE. Ten exposures of the gallium to the source, whose initial strength was 409{+-}2kCi, were carried out during the period April to September 2004. The {sup 71}Ge produced by the reaction {sup 71}Ga({nu}{sub e},e{sup -}){sup 71}Ge was extracted, purified, and counted. The measured production rate was 11.0{sub -0.9}{sup +1.0} (stat){+-}0.6 (syst) atoms of {sup 71}Ge/d, which is 0.79{sub -0.10}{sup +0.09} of the theoretically calculated production rate. When all neutrino source experiments with gallium are considered together, there is an indication the theoretical cross section has been overestimated.
Chiroptical activity of gas-phase propylene oxide predicting the handedness of interstellar circular polarization in the presolar nebula

Propylene oxide, the first chiral molecule recently detected in the interstellar medium, has once again raised the question whether biomolecular chirality might have cosmic origins. However, accurate chiroptical properties of propylene oxide in the ultraviolet spectral range necessary to suggest possible asymmetric synthetic routes in the gas phase are scarce. Here, we report on the first experimental measurements of the anisotropy spectra of gas-phase propylene oxide in the vacuum ultraviolet spectral range. Our experimental results provide novel insights into the handedness of interstellar circular polarization at the dawn of molecular evolution of our star- and planet-forming region. Besides the fundamental importance of this new investigation for understanding the origin and evolution of homochirality on Earth, our high-resolution experimental electronic circular dichroism data will inspire new efforts in quantum computational spectroscopy.
X-Ray Emission from the Old Pulsar B0950+08

We present the timing and spectral analyses of the XMM-Newton data on the 17 Myr old, nearby radio pulsar B0950+08. This observation revealed pulsations of the X-ray flux of PSR B0950+08 at its radio period, P ≃ 253 ms. The pulse shape and pulsed fraction are apparently different at lower and higher energies of the observed 0.2-10 keV energy range, which suggests that the radiation cannot be explained by a single emission mechanism. The X-ray spectrum of the pulsar can be fitted with a power-law model with a photon index Γ = 1.75 ± 0.15 and an (isotropic) luminosity LX = (9.8 ± 0.2) × 1029 ergs s-1 in the 0.2-10 keV range. Better fits are obtained with two-component, power-law plus thermal models with Γ = 1.30 ± 0.10 and LX = (9.7 ± 0.1) × 1029 ergs s-1 for the power-law component, which presumably originates from the pulsar's magnetosphere. The thermal component, dominating at E ≲ 0.7 keV, can be interpreted as radiation from heated polar caps on the neutron star surface covered with a hydrogen atmosphere. The inferred effective temperature, radius, and bolometric luminosity of the polar caps are TPC ≈ 1 MK, RPC ≈ 250 m, and LPC ≈ 3 × 1029 ergs s-1. Optical through X-ray nonthermal spectrum of the pulsar can be described as a single power law with Γ = 1.3-1.4 for the two-component X-ray fit. The ratio of the nonthermal X-ray (1-10 keV) luminosity to the nonthermal optical (4000-9000 Å) luminosity, ≈360, is within the range of 102-103 observed for younger pulsars, which suggests that the magnetospheric X-ray and optical emissions are powered by the same mechanism in all pulsars, independent of age and spin-down power. Assuming a standard neutron star radius, the upper limit on the temperature of the bulk of the neutron star surface, inferred from the optical and X-ray data, is about 0.15 MK. We also analyze X-ray observations of several other old pulsars, B2224+65, J2043+2740, B0628-28, B1813-36, B1929+10, and B0823+26, and compare their properties with those of PSR B0950+08.
PSCz superclusters: detection, shapes and cosmological implications

We study the possibility of correctly identifying, from the smooth galaxy density field of the PSCz flux-limited catalogue, high-density regions (superclusters) and recovering their true shapes in the presence of a bias introduced by the coupling between the selection function and the constant radius smoothing. We quantify such systematic biases in the smoothed PSCz density field and after applying the necessary corrections we study supercluster multiplicity and morphologies using a differential geometry definition of shape. Our results strongly suggest that filamentary morphology is the dominant feature of PSCz superclusters. Finally, we compare our results with those expected in three different cosmological models and find that the Λ cold dark matter (CDM) model (ΩΛ=1−Ωm=0.7) performs better than Ωm=1 CDM models.
Mobile sensing in psychological and educational research: Examples from two application fields

Abstract Digital technologies play an important role in our daily lives. Smartphones and tablet computers are very common worldwide and are available for everybody from a very early age. This trend offers the opportunity to track digital usage data for psychological and educational research purposes. The current paper introduces two research projects, the PhoneStudy and Learning4Kids that both use mobile sensing software to collect ecologically valid data on the usage of applications installed on smartphones and tablets. This usage data is used for statistical analyses, for a reward system, and to provide feedback to the study participants. The advantages and challenges of using mobile sensing compared to conventional forms of assessments, and the potential applications of mobile sensing in psychological and educational research are discussed.
Dielectric properties of cereal stubble infected with Bipolaris sorokiniana, Fusarium pseudograminearum and Pyrenophora teres in the microwave frequency range

Abstract Cereal production in Australia is severely impacted by stubble-borne pathogens which can survive multiple seasons within cereal residues (stubble). Microwave radiation may be able to reduce or eliminate the pathogens, but the energy requirements first need defining. Hence, the dielectric properties of wheat and barley stubble with different pathogen loads were investigated at 10%, 15%, 30% and 100% moisture content using an open-ended coaxial probe in a spectral band covering 915, 2450, and 5800 MHz. A significant increase in dielectric constant and loss factor was observed with increasing stubble moisture. The dielectric constant and loss factor were lower in the crown (basal) section of stubble compared with the stem (20 cm from base), due to differences in density. When stubble moisture was 100%, the loss factor of barley was higher than wheat. Infection of stubble by different pathogens did not affect the dielectric properties. Microwave heating could therefore be an effective method to heat cereal stubble to eradicate a range of cereal pathogens, especially at lower frequencies and high moisture content, at which the loss factor is high. This research serves as a starting point to define requirements for further development of effective microwave radiation treatments under field conditions.
Practical teaching tips on designing authentic assessments in Tourism, Hospitality and Events (THE) higher education

ABSTRACT This paper presents practical teaching tips on how to design authentic assessments in THE education. As higher education providers are placing more emphasis on preparing students to be job ready, resulting in pivoting courses to deliver new approaches due to the pandemic. Considering new frameworks that assist in student learning and positive student experience are now essential. New ways of delivery that involve virtual platforms, students as co-creators, and industry are key pedagogical shifts in the reengineering of assessments. Therefore, ensuring assessments continue to reflect real-world practices while considering how students rebuild trust for industry recovery are current critical key considerations.
Examining the role of EWOM on tourism intention for adventure tourists

Abstract This study’s goal is to examine the impact of Adventure electronic word of mouth (AEWOM) on Adventure Tourist Attitude (ATA), Adventure Subjective Norms (ASN), Adventure Perceived Behavioral Control (APBC), and Adventure Tourist Intention (ATI). The prospective travellers are the respondents for this study. The data is collected through online and offline modes, and purposive sampling. A seven-point Likert scale ranging from “Strongly Agree” to “Strongly Disagree” is used. A total of 250 valid respondents were used for this study. We have used smart PLS 3.3. 3 and a structural equation model (SEM) with partial least squares (PLS) to test the path analysis and bootstrapping to establish the relationship between the variables. This study shows that AEWOM has a positive and significant relationship with ATA, ASN, APBC, and ATI. ATA and APBC have positive and significant relationships with ATI, but ASN doesn’t have a positive and significant relationship with ATI. The paper has discussed the implications of the relationships towards tourism businesses and public policy.
Squeezing and entanglement delay using slow light

We examine the interaction of a weak probe with N atoms in a Lambda-level configuration under the conditions of electromagnetically induced transparency (EIT). In contrast to previous works on EIT, we calculate the output state of the resultant slowly propagating light field while taking into account the effects of ground state dephasing and atomic noise for a more realistic model. In particular, we propose two experiments using slow light with a nonclassical probe field and show that two properties of the probe, entanglement and squeezing, characterizing the quantum state of the probe field, can be well-preserved throughout the passage.
The antinuclear power movement in India after the Fukushima disaster: the case of Koodankulam

ABSTRACT This article shows how the international nuclear disaster in Fukushima affected the antinuclear movement in Koodankulam by using the cross-national diffusion model proposed by Kriesi, Koopmans, Duyvendak and Giugni (1995) . It examines the impact of the international disaster on the antinuclear movement and its subsequent expansion in terms of protest events and organizational trajectories. It also describes the new participants and actors in this antinuclear power issue. The research questions are addressed through archives, handbills, unpublished documents, and semi-structured interviews. I argue that diffusion of information and domestic opportunities helped the antinuclear groups erect a protest camp that offered manufactured vulnerability. This induced several meso and micro level social movement organizations and political parties to join the antinuclear movement, leading to expansion at the organizational level and the formation of coalitions. Further, the participation of newly joined social movement organizations and political parties in the mobilization helped the movement expand its protest events and led to an increase in the level of contention. The study contributes to the study of antinuclear movements and cross-national diffusion.
You are what you click: using machine learning to model trace data for psychometric measurement

Abstract Assessment trace data, such as mouse positions and their timing, offer interesting and provocative reflections of individual differences yet are currently underutilized by testing professionals. In this article, we present a 10-step procedure to maximize the probability that a trace data modeling project will be successful: 1) grounding the project in psychometric theory, 2) building technical infrastructure to collect trace data, 3) designing a useful developmental validation study, 4) using a holdout validation approach with collected data, 5) using exploratory analysis to conduct meaningful feature engineering, 6) identifying useful machine learning algorithms to predict a thoughtfully chosen criterion, 7) engineering a machine learning model with meaningful internal cross-validation and hyperparameter selection, 8) conducting model diagnostics to assess if the resulting model is overfitted, underfitted, or within acceptable tolerance, and 9) testing the success of the final model in meeting conceptual, technical, and psychometric goals. If deemed successful, trace data model predictions could then be engineered into decision-making systems. We present this framework within the broader view of psychometrics, exploring the challenges of developing psychometrically valid models using such complex data with much weaker trait signals than assessment developers have typically attempted to model.
Interstellar Carbon in Translucent Sight Lines

We report interstellar C II column densities or upper limits determined from weak absorption of the 2325.4029 Å intersystem transition observed in six translucent sight lines (AV ≳ 1) with the Space Telescope Imaging Spectrograph (STIS). The sight lines sample a wide range of interstellar characteristics, including total to selective extinction, RV = 2.6-5.1; average hydrogen density along the sight line, ⟨n(H)⟩ = 3-14 cm-3; and fraction of H in molecular form, 0-~40%. Four of the sight lines, those toward HD 37021, HD 37061, HD 147888, and HD 207198, have interstellar gas-phase abundances that are consistent with the diffuse sight line ratio of 161 ± 17 carbon atoms in the gas per million hydrogen nuclei. We note that while it has a gas-phase carbon abundance that is consistent with the other sight lines, a large fraction of the C II toward HD 37061 is in an excited state. The sight line toward HD 152590 has a measured interstellar gas-phase carbon abundance that is well above the diffuse sight line average; the column density of C in this sight line may be overestimated because of noise structure in the data. Toward HD 27778 we find a 3 σ abundance upper limit of ≤108 C atoms in the gas per million H, a substantially enhanced depletion of C as compared to the diffuse sight line value. The interstellar characteristics toward HD 27778 are otherwise not extreme among the sample, except for an unusually large abundance of CO molecules in the gas.
SCATTERING OBLIQUELY INCIDENT MICROWAVES BY A MOVING PLASMA COLUMN.

The problem of the interaction of obliquely incident microwaves with a plasma column which is moving uniformly in the axial direction is treated analytically. An arbitrary polarization for the incident plane wave is assumed. Two methods in solving this problem are presented. Extensive numerical results for the scattered energy in the backward and broadside directions and the angular distribution of the scattered energy are obtained for various interesting ranges of the parameters involved. It is found that cross‐polarized field components are induced even at normal incidence when the plasma medium is moving with respect to the observer and that cross‐polarized field components disappear at an incident angle θ0=sin−1(vz/c), where vz is the velocity of the moving plasma and c is the speed of light in vacuum when the plasma column is imbedded in free space.
An evolutionarily conserved olfactory receptor is required for sex differences in blood pressure

Sex differences in blood pressure are well-established, with premenopausal women having lower blood pressure than men by ∼10mmHg; however, the underlying mechanisms are not fully understood. We report here that olfactory receptor 558 (Olfr558), which has not previously been studied in non-olfactory tissues, localizes to vascular smooth muscle cells in numerous tissues including the kidney and heart. In the kidney, Olfr558 colocalizes with renin (a hormone that plays a key role in blood pressure regulation) in the renal afferent arteriole. Based on the localization of Olfr558, we hypothesized that Olfr558 plays a role in blood pressure regulation. We find that sex differences in blood pressure are intact in Olfr558 wildtype (WT) mice, but, are absent in Olfr558 knockout (KO) mice. We find that male KO mice have lowered diastolic blood pressure, decreased renin expression and activity, and altered vascular reactivity. Female KO mice exhibit increased blood pressure and increased pulse wave velocity, indicating increased vascular stiffness. The human ortholog of Olfr558, OR51E1, was previously identified as a locus associated with diastolic blood pressure. We report here that a rare OR51E1 missense variant has a statistically significant sex interaction effect with diastolic blood pressure, increasing diastolic blood pressure in women but decreasing it in men. In addition, we characterize how two different clinically relevant OR51E1 variants influence OR51E1 signaling in vitro. In sum, our findings demonstrate an evolutionarily conserved role for Olfr558/OR51E1 to mediate sex differences in blood pressure by altering renin, vascular reactivity, and arterial stiffness.
Adaptation to ex vivo culture drives human haematopoietic stem cell loss of repopulation capacity in a cell cycle independent manner

Loss of long-term haematopoietic stem cell function (LT-HSC) hampers the success of ex vivo HSC gene therapy and expansion procedures, but the kinetics and the mechanisms by which this occurs remain incompletely characterized. Here through time-resolved scRNA-Seq, matched in vivo functional analysis and the use of a reversible in vitro system of early G1 arrest, we define the sequence of transcriptional and functional events occurring during the first ex vivo division of human LT-HSCs. We demonstrate that contrary to current assumptions, loss of long-term repopulation capacity during culture is independent of cell cycle progression. Instead it is a rapid event that follows an early period of adaptation to culture, characterised by transient gene expression dynamics and constrained global variability in gene expression. Cell cycle progression however contributes to the establishment of differentiation programmes in culture. Our data have important implications for improving HSC gene therapy and expansion protocols.
Analysis of Cancer Genomic Amplifications Identifies Druggable Collateral Dependencies within the Amplicon

The identification of novel therapeutic targets for specific cancer molecular subtypes is crucial for the development of precision oncology. In the last years, CRISPR/Cas9 screens have accelerated the discovery and validation of new targets associated with different tumor types, mutations or fusions. However, there are still many cancer vulnerabilities associated with specific molecular features that remain to be explored. Here we used data from CRISPR/Cas9 screens in 954 cancer cell lines to identify gene dependencies associated with 16 common cancer genomic amplifications. We found that high-copy number genomic amplifications generate multiple collateral dependencies within the amplified region in 94% of cases. Further, to prioritize candidate targets for each chromosomal region amplified, we integrated gene dependency parameters with both druggability data and subcellular location. Finally, analysis of the relationship between gene expression and gene dependency leads to the identification of genes, the expression of which may constitute predictive biomarkers of dependency.
Investigating the potential of packed cell volume for deducing hemoglobin: Cholistani camels in perspective

In human medical practice, a hematological rule of three has been validated for healthy human populations. One such formula is estimating hemoglobin (Hb) levels as 1/3rd of Packed Cell Volume (PCV). However, no such hematological formulae have been devised and validated for veterinary medical practice. The present study was devised with an aim to evaluate the relationship between hemoglobin (Hb) concentration and Packed Cell Volume (PCV) in camels (n = 215) being reared under pastoralism, and to devise a simple pen-side hematological formula for estimation of Hb from PCV. The PCV was determined through microhematocrit method whereas Hb estimation by cyanmethaemoglobin method (HbD). The Hb was also calculated as 1/3rd of PCV and was dubbed as calculated Hb (HbC). Overall HbD and HbC were significantly (P≥0.05) different. Similar results were attained for all study groups i.e. males (n = 94) and females (n = 121), and young (n = 85) and adult (n = 130) camels. The corrected Hb (CHb) was deduced through regression prediction equation attained from linear regression model. Scatterplots were drawn, linear regression was carried out, and Bland Altman chart was built for agreement of both methods of Hb estimation. A non-significant (P≥0.05) difference was noticed between HbD and CHb. Bland Altman agreement analysis revealed satisfactory agreement between HbD and CHb and the data was distributed closely around the mean difference line (Mean = 0.1436, 95% CI = 3.00, -2.72). A simplified pen-side hematological formula for deducing Hb concentration from PCV is accordingly recommended viz. Hb concentration (g/dL) = 0.18(PCV)+5.4 for all age and gender groups of camels instead of its calculation as one-third of PCV.
Clonal amplification-enhanced gene expression for cell-free directed evolution

In cell-free gene expression, low input DNA concentration severely limits the phenotypic output, which may impair in vitro protein evolution efforts. We address this challenge by developing CADGE, a strategy that is based on clonal isothermal amplification of a linear gene-encoding dsDNA template by the minimal Φ29 replication machinery and in situ transcription-translation. We demonstrate the utility of CADGE in bulk and in clonal liposome microcompartments to boost up the phenotypic output of soluble and membrane-associated proteins, as well as to facilitate the recovery of encapsulated DNA. Moreover, we report that CADGE enables the enrichment of a DNA variant from a mock gene library either via a positive feedback loop-based selection or high-throughput screening. This new biological tool can be implemented for cell-free protein engineering and the construction of a synthetic cell.