Miracle-dz/UniFAR-FTUs huggingface dataset:
Potassium Ion Channels of Chlorella Viruses Cause Rapid Depolarization of Host Cells during Infection

ABSTRACT Previous studies have established that chlorella viruses encode K+ channels with different structural and functional properties. In the current study, we exploit the different sensitivities of these channels to Cs+ to determine if the membrane depolarization observed during virus infection is caused by the activities of these channels. Infection of Chlorella NC64A with four viruses caused rapid membrane depolarization of similar amplitudes, but with different kinetics. Depolarization was fastest after infection with virus SC-1A (half time [t1/2], about 9 min) and slowest with virus NY-2A (t1/2, about 12 min). Cs+ inhibited membrane depolarization only in viruses that encode a Cs+-sensitive K+ channel. Collectively, the results indicate that membrane depolarization is an early event in chlorella virus-host interactions and that it is correlated with viral-channel activity. This suggestion was supported by investigations of thin sections of Chlorella cells, which show that channel blockers inhibit virus DNA release into the host cell. Together, the data indicate that the channel is probably packaged in the virion, presumably in its internal membrane. We hypothesize that fusion of the virus internal membrane with the host plasma membrane results in an increase in K+ conductance and membrane depolarization; this depolarization lowers the energy barrier for DNA release into the host.
Assessment of School-Aged Children with Autism Spectrum Disorder

An increasing number of school children are diagnosed with Autism Spectrum Disorder (ASD). These children may be referred for assessments for a variety of reasons, including to assess for intellectual impairments, eligibility for support, or to monitor progress. Characteristics of ASD, such as social communication difficulties, as well as common comorbid conditions and behaviours, may make such assessments more challenging than for assessments with children without ASD. The present article overviews characteristics of ASD, challenges with assessment, and strategies to choose, prepare for, and complete a standardised assessment to provide information to assist psychologists and other professionals to complete a valid assessment of a child with ASD. Resources and recommendations for further reading are provided.
Effort, exaggeration and malingering after concussion

Although most individuals who suffer a mild traumatic brain injury have complete recovery, a number experience persistent symptoms that appear inconsistent with the severity of the injury. Symptoms may be ascribed to malingering, exaggeration or poor effort on cognitive testing. The purpose of this paper is to propose that previously unconsidered factors, informed by social psychology and behavioural economics, can appear as ‘symptom magnification’ or ‘poor effort’, which are incorrectly interpreted as the result of a conscious process. These are complex and multi-determined behaviours with a unique differential diagnosis which have important implications for research, evaluation and treatment.
The languages classroom: place of comfort or obstacle course?

This article problematises certain aspects of methodology used for speaking practice and commonly applied in contemporary language teaching classrooms. It examines these particularly with relevance to diversity in adult learning groups. The aspects under scrutiny include the use of personal information in tasks, pair and group work, target language as classroom language, physical movement, communication of task expectation and rationale, and student opportunity to opt out of or adapt tasks. It discusses how student reaction to these methodological aspects can affect their integration into the interactive group situation, their engagement in and management of tasks set by the teacher, and, as a consequence, their success in the development of speaking skills. Results from a survey of beginner language learners at the Open University give an insight into student reaction to these areas of methodology and help the authors to reach conclusions about facilitative and inhibiting factors which make the classroom either a place of comfort or an obstacle course. As a result of survey data and comments, the authors exhort teachers to be sensitive and flexible when designing tasks and to be alert to how they manage them. They also need to be attentive to how students respond when carrying them out in the classroom context so that successful integration is guaranteed for as many students as possible.
Patterns of macroparasite aggregation in wildlife host populations

Frequency distributions from 49 published wildlife host–macroparasite systems were analysed by maximum likelihood for goodness of fit to the negative binomial distribution. In 45 of the 49 (90%) data-sets, the negative binomial distribution provided a statistically satisfactory fit. In the other 4 data-sets the negative binomial distribution still provided a better fit than the Poisson distribution, and only 1 of the data-sets fitted the Poisson distribution. The degree of aggregation was large, with 43 of the 49 data-sets having an estimated k of less than 1. From these 49 data-sets, 22 subsets of host data were available (i.e. host data could be divided by either host sex, age, where or when hosts were sampled). In 11 of these 22 subsets there was significant variation in the degree of aggregation between host subsets of the same host–parasite system. A common k estimate was always larger than that obtained with all the host data considered together. These results indicate that lumping host data can hide important variations in aggregation between hosts and can exaggerate the true degree of aggregation. Wherever possible common k estimates should be used to estimate the degree of aggregation. In addition, significant differences in the degree of aggregation between subgroups of host data, were generally associated with significant differences in both mean parasite burdens and the prevalence of infection.
Anonymizing set-valued data by nonreciprocal recoding

Today there is a strong interest in publishing set-valued data in a privacy-preserving manner. Such data associate individuals to sets of values (e.g., preferences, shopping items, symptoms, query logs). In addition, an individual can be associated with a sensitive label (e.g., marital status, religious or political conviction). Anonymizing such data implies ensuring that an adversary should not be able to (1) identify an individual's record, and (2) infer a sensitive label, if such exists. Existing research on this problem either perturbs the data, publishes them in disjoint groups disassociated from their sensitive labels, or generalizes their values by assuming the availability of a generalization hierarchy. In this paper, we propose a novel alternative. Our publication method also puts data in a generalized form, but does not require that published records form disjoint groups and does not assume a hierarchy either; instead, it employs generalized bitmaps and recasts data values in a nonreciprocal manner; formally, the bipartite graph from original to anonymized records does not have to be composed of disjoint complete subgraphs. We configure our schemes to provide popular privacy guarantees while resisting attacks proposed in recent research, and demonstrate experimentally that we gain a clear utility advantage over the previous state of the art.
Design of Ultra-Wideband Low-Noise Amplifiers in 45-nm CMOS Technology: Comparison Between Planar Bulk and SOI FinFET Devices

This paper deals with the design of single-stage differential low-noise amplifiers for ultra-wideband (UWB) applications, comparing state-of-the-art planar bulk and silicon-on-insulator (SOI) FinFET CMOS technologies featuring 45-nm gate length. To ensure a broadband input impedance matching, the g m-boosted topology has been chosen. Furthermore, the amplifiers have been designed to work over the whole UWB band (3.1-10.6 GHz), while driving a capacitive load, which is a realistic assumption for direct conversion receivers where the amplifier directly drives a mixer. The simulations (based on compact models obtained from preliminary measurements) highlight that, at the present stage of the technology development, the planar version of the circuit appears to outperform the FinFET one. The main reason is the superior cutoff frequency of planar devices in the inversion region, which allows the achievement of noise figure and voltage gain comparable to the FinFET counterpart, with a smaller power consumption.
The Symbolic Species: The Co-evolution of Language and the Brain

This revolutionary book provides fresh answers to long-standing questions of human origins and consciousness. Drawing on his breakthrough research in comparative neuroscience, Terrence Deacon offers a wealth of insights into the significance of symbolic thinking: from the co-evolutionary exchange between language and brains over two million years of hominid evolution to the ethical repercussions that followed man's newfound access to other people's thoughts and emotions. Informing these insights is a new understanding of how Darwinian processes underlie the brain's development and function as well as its evolution. In contrast to much contemporary neuroscience that treats the brain as no more or less than a computer, Deacon provides a new clarity of vision into the mechanism of mind. It injects a renewed sense of adventure into the experience of being human.
Writing Organizational Analysis into Foucault

In certain areas of social science and the humanities, Foucault has had an enormous influence in recent years. In particular, history, feminist and gender research, literary studies, philosophy, politics, psychiatry, and sociology have not been able to ignore the radical interventions of Foucault's attempts to think the unthought. Organization theory has not been immune to Foucault's constant challenge to what is taken for granted and his skeptical views of the work of what he named `universal intellectuals', who claim to speak on behalf of individuals, groups or populations. Foucault's skepticism about historicist and totalizing systems of thought and practice fits the era. His demand is that we question conventional thinking not because it is necessarily wrong but because it is dangerous. Contrasted with the way that much organization theory simply uses Foucault as a convenient resource, this article attempts to push organizational analysis toward Foucault until the pips squeak.
Supermum, superwife, supereverything: performing femininity in the transition to motherhood

The aim of this qualitative study was to comprehend how mothers understood and accounted for their experiences in relation to the ideology of motherhood which has been socially constructed as a critical aspect of femininity. Semi‐structured interviews were conducted with 24 primiparous and multiparous women, and transcripts analysed using open and axial coding with triangulation. Using a material‐discursive approach to interpret the data, two higher order themes are presented: ‘the realization of new motherhood’ and ‘coping with new motherhood’. These themes demonstrate how unprepared for motherhood the women were and how their expectations were based on various myths of motherhood. This led to feelings of inadequacy as they struggled with the myth versus reality discrepancy. However, they could not be seen to be inadequate and therefore employed greater efforts to portray themselves as supermum, superwife, supereverything and hide the opposite. These findings are interpreted within the context of the social construction of femininity and how it is performed within motherhood. Implications for antenatal and postpartum care are discussed.
Policy Search Based Relational Reinforcement Learning using the Cross-Entropy Method

Relational Reinforcement Learning (RRL) is a subfield of machine learning in which a learning agent seeks to maximise a numerical reward within an environment, represented as collections of objects and relations, by performing actions that interact with the environment. The relational representation allows more dynamic environment states than an attribute-based representation of reinforcement learning, but this flexibility also creates new problems such as a potentially infinite number of states. This thesis describes an RRL algorithm named Cerrla that creates policies directly from a set of learned relational “condition-action” rules using the Cross-Entropy Method (CEM) to control policy creation. The CEM assigns each rule a sampling probability and gradually modifies these probabilities such that the randomly sampled policies consist of ‘better’ rules, resulting in larger rewards received. Rule creation is guided by an inferred partial model of the environment that defines: the minimal conditions needed to take an action, the possible specialisation conditions per rule, and a set of simplification rules to remove redundant and illegal rule conditions, resulting in compact, efficient, and comprehensible policies. Cerrla is evaluated on four separate environments, where each environment has several different goals. Results show that compared to existing RRL algorithms, Cerrla is able to learn equal or better behaviour in less time on the standard RRL environment. On other larger, more complex environments, it can learn behaviour that is competitive to specialised approaches. The simplified rules and CEM’s bias towards compact policies result in comprehensive and effective relational policies created in a relatively short amount of time.
Cultural and Gender Differences in Perceptions of Stressors and Coping Skills

The main objective of this research is to test the universal nature of stress and coping behaviour among overseas college students in China and to provide basic information towards understanding the problems that result from stress and coping which can best be defined in cultural terms. The sample consisted of 83 students from Africa and 76 students from Western countries attending eleven universities in China. Results indicated that academic and interpersonal sources of stress were the most common stressors perceived by the two groups. High levels of pressures and challenges perceived by both African and Western student were classified as daily hassles. No group differences existed in subtotal perceptions of interpersonal, intrapersonal, academic and environmental stressors. Group variations existed only in their sub-divisional areas of stress. Minor differences in perception of stressors such as attaining lower grades, missing too many classes and working with unfamiliar people were observed between male and female students. In comparison to African students, Western students demonstrated the highest ability to cope with stress. The two groups differed on the level of most measures, with Western subjects scoring higher on all seven sub-scales. On the coping scale, they did best on `ability to relax'. Both African and Western students scored lowest on `the resourceful coping' scale. Significant differences were observed between Western and African students in four out of the seven sub-scales measured. No differences were found between men and women in their ways of coping with stress in China.
Is journal publication obsolescent

STORAGE AND RETRIEVAL of information is currently a subject of considerable urgency and one that affects all branches of science. I know that PHYSICS TODAY readers are concerned about the problem, and I suspect that they are, as I am, rather uneasy about many trends in journal publication. I want to discuss some of them in detail, but first I would like very briefly to present some background information.
Case and Tense in the ‘fossilized’ steady state

This article reviews recent SLA studies which have methodologically assumed a direct relation between the acquisition of inflectional morphology and the development of functional phrase structure in the syntax. Results from naturalistic production data collected over eight years apart are reported, establishing the ‘fossilization’ of English L2 tense morphology for an adult native Chinese speaker at a consistently very low rate of suppliance (approximately 34%) in obligatory contexts. Nevertheless, in addition to robust evidence for CP in the grammar, the data also show perfect distribution of pronominal case (100%) in all contexts, suggesting the presence of a TP bearing a fully specified [± finite] feature. Viewed in light of the steady state (in other words, where grammatical development has ‘ended up’), these results indicate that the courses of syntactic and morphological development are independent and that the mapping between them is much less direct than previously supposed. I conclude that it is this mapping itself, in the morphology or PF component, which may be imperfectly acquired, and from which a lack of functional categories or extended phrase structure development may not be inferred.
Rapid Histochemistry Using Slow Off-rate Modified Aptamers With Anionic Competition

Immunohistochemistry is used in both research and clinical settings to identify proteins in tissue samples. Despite the power and versatility of immunohistochemistry, limitations are imposed by the slow diffusion of antibodies through tissue and the need for secondary staining or signal amplification. Aptamers can circumvent these limitations, but their application has been hindered by nonspecific binding to cellular components, particularly in the nucleus. Here we describe unique slow off-rate modified aptamers that facilitate rapid and selective binding to target proteins in tissue. Specifically, we have developed a fluorescent aptamer that binds to the human epidermal growth factor receptor 2 (HER2) in breast carcinomas quickly and specifically, and we have shown that the slow off-rate of the aptamer from the HER2 protein contributes to its selectivity. These findings open the door to aptamer histochemistry applications in both research and clinical settings, including intraoperative diagnostics in which speed and accuracy are paramount.
Changes in HPBMC markers of immmune function following controlled short-term inhalation exposures of humans to hardwood smoke

Abstract Previous studies have shown that complex mixtures containing particulate matter (PM) and polycyclic aromatic hydrocarbons (PAHs) produce systemic immunotoxicity in animal models following inhalation exposures. While we and others have shown that emissions associated with hardwood smoke (HWS), cigarette smoke and diesel exhaust can suppress the immune systems of animals in vitro and in vivo, there have been few immune function studies on human peripheral blood mononuclear cells (HPBMC) following exposure of humans to HWS. Our work shows that T cells are an important targets of PM and PAH immunotoxicity. These studies were conducted on HPBMC from 14 human volunteers receiving four 2 h nightly exposures to clean air or HWS at a concentration of 500 ug/m3. We measured anti-CD3/anti-CD28 stimulated T-cell proliferation and HPBMC cytokine production in cell supernatants, including interleukin 1β (IL-1β), tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), interleukin 8 (IL-8), TH1 cytokines γIFN and IL-2, TH2 cytokine IL-4, Th17 cytokine interleukin 17A (IL-17A) and interleukin 10 (IL-10). We analyzed results using analysis of variance (ANOVA), t-tests and Pearson correlation. Results showed that there was significant variation in the amount of T-cell proliferation observed following polyclonal activation with anti-CD3/anti-CD28 antibodies in both the air and HWS-exposed groups. There was not a significant effect of HWS on T-cell proliferation. However, we did find a strong relationship between the presence of proinflammatory cytokines (IL-1β, TNF-α, IL-6, but not IL-8) and the amount of T-cell proliferation seen in individual donors, demonstrating that brief exposures of humans to HWS can produce changes in systemic immunity that is associated with proinflammatory cytokines.
Federal Reserve Bank of Minneapolis Research Department Sta ff Report 491 September 2013 Linkages across Sovereign Debt Markets

We develop a multicountry model in which default in one country triggers default in other countries. Countries are linked to one another by borrowing from and renegotiating with common lenders with concave payoffs. A foreign default increases incentives to default at home because it makes new borrowing more expensive and defaulting less costly. Foreign defaults tighten home bond prices because they lower lenders’ payoffs. Foreign defaults make home default less costly by lowering future recoveries, because countries can extract more surplus if they renegotiate simultaneously. In our model, the home country may default only because the foreign country is defaulting. This dependency arises during fundamental foreign defaults, where the foreign country defaults because of high debt and low income, and also during self-fulfilling defaults, where both countries default only because the other is defaulting. The simultaneity in defaults induces a correlation in interest rate spreads across countries. The model can rationalize some of the recent economic events in Europe.
Intra-Osseous Access (EZ-IO®) for Resuscitation: UK Military Combat Experience

Military trauma produces predominantly blast and fragmentation injury, commonly resulting in haemorrhagic shock. Injury patterns to limbs are such that the conventional sites for venous cannulation may be unsuitable. The EZ-IO® (Vidacare®, San Antonio) system is one of a number of novel products designed for intraosseous (IO) access in adults or children. In three months of combat casualty care in Helmand Province, Afghanistan, the UK Defence Medical Services used EZ-IO® for emergency vascular access on 26 patients (16 adults; 10 children). 23/26 patients had IO access obtained in the emergency department; 3/26 had pre-hospital IO access within a tactically flying helicopter. A total of 32 needles were inserted, with 97% effective function. IO needles were used to administer fluid (crystalloid, packed red cells and fresh frozen plasma) and drugs (analgesics, cardiac arrest drugs, antibiotics, drugs for both rapid sequence induction and maintenance of anaesthesia). No complication of infection was noted, but pain was observed in responsive patients with the pain of infusion exceeding that of the underlying injuries in 3 cases.
Aspectual perspective taking in event construal in L1 and L2 Dutch

Abstract The present study focuses on the role of grammatical aspect in event construal and its function in encoding the specificity of an event. We investigate whether advanced L2 learners (L1 German) acquire target-like patterns of use of progressive aspect in Dutch, a language in which use of aspect depends on specific situation types. We analyze use of progressive markers and patterns in information selection, relating to specific features of agents or actions in dynamic event scenes. L2 event descriptions are compared with L1 Dutch and L1 German data. The L2 users display the complex situation-dependent patterns of use of aspect in Dutch, but they do not select the aspectual viewpoint (aan he construction) to the same extent as native speakers. Moreover, the encoding of specificity of the events (mentioning of specific agent and action features) reflects L1 transfer, as well as target-like performance in specific domains.
Portfolio choice with jumps: A closed-form solution

We analyze the consumption-portfolio selection problem of an investor facing both Brownian and jump risks. We bring new tools, in the form of orthogonal decompositions, to bear on the problem in order to determine the optimal portfolio in closed form. We show that the optimal policy is for the investor to focus on controlling his exposure to the jump risk, while exploiting differences in the Brownian risk of the asset returns that lies in the orthogonal space.