Miracle-dz/UniFAR-FTUs huggingface dataset:
The Early Effect of Carotid Artery Stenting on Antioxidant Capacity and Oxidative Stress in Patients with Carotid Artery Stenosis

The treatment of carotid artery stenosis is associated with the risk of complications, which may include stroke after carotid artery stenting (CAS) and myocardial infarction after carotid endarterectomy (CEA). The imbalance between prooxidative mechanisms and antioxidant capacity creates a milieu of factors, which may increase the risk of complications after endovascular procedures. We have examined 43 consecutive patients with carotid artery stenosis. Sera were analyzed for the activity of paraoxonase (PON) and arylesterase (ARE), sulfhydryl groups (SG), malondialdehyde (MDA), and conjugated dienes (CD) concentrations by means of spectrophotometric methods before and next day after CAS. We have found lowered PON (P = 0.0032), increase in ARE activity (P = 0.0058), and decrease in sulfhydryl groups concentration (P = 0.0267). No effect on absolute MDA and CD concentrations was observed. The degree of carotid artery stenosis correlated negatively with PON/ARE ratio after CAS (r S = −0.507, P = 0.0268). To conclude, CAS influences both enzymatic (differently, PON and ARE activity) and nonenzymatic antioxidant defense. Females are more susceptible to lipid peroxidation after CAS. PON/ARE ratio after CAS correlated with the degree of carotid artery stenosis. The changes (deltas) in ARE activity, SG, and MDA concentrations correlated with the severity of neurological deficit and disability.
Development and testing of a low group-delay Woofer channel for PEP-II

The PEP-II High and Low energy rings require active longitudinal feedback to control coupled-bunch instabilities. The driving impedances originate from higher order modes as well as the accelerating fundamental impedance. The PEP-II RF systems use direct and comb loop feedback to reduce the cavity fundamental impedance, though the remaining low-mode impedance is providing the fastest growing unstable modes in both HER and LER. Since commissioning the longitudinal feedback systems have used a dedicated“woofer” channel to apply the low-frequency correction kick via the RF system. The performance of this original controller is limited by the maximum gain that can be supported due to the processing delay (group delay), as well as the difficulty in configuring a common correction controller that acts via two correction paths. A dedicated low-mode signal processing system has been developed to allow higher damping rates. It is a digital processing channel, operating at a 10 MHz sampling rate, and implementing flexible 5 to 14 tap FIR control filters. The design of the channel and initial control filters is presented, as are initial machine experiments quantifying the damping and noise floor of this low group delay woofer system.
XNET: a reliable content-based publish/subscribe system

Content-based publish/subscribe systems are usually implemented as a network of brokers that collaboratively route messages from information providers to consumers. A major challenge of such middleware infrastructures is their reliability and their ability to cope with failures in the system. In this paper, we present the architecture of the XNET XML content network and we detail the mechanisms that we implemented to gracefully handle failures and maintain the system state consistent with the consumer population at all times. In particular, we propose several approaches to fault tolerance so that our system can recover from various types of router and link failures. We analyze the efficiency of our techniques in a large scale experimental deployment on the PlanetLab testbed. We show that XNET does not only offer good performance and scalability with large consumer populations under normal operation, but can also quickly recover from system failures.
The tyrosine kinase encoded by the MET proto-oncogene is activated by autophosphorylation

Protein tyrosine kinases are crucially involved in the control of cell proliferation. Therefore, the regulation of their activity in both normal and neoplastic cells has been under intense scrutiny. The product of the MET oncogene is a transmembrane receptorlike tyrosine kinase with a unique disulfide-linked heterodimeric structure. Here we show that the tyrosine kinase activity of the MET-encoded protein is powerfully activated by tyrosine autophosphorylation. The enhancement of activity was quantitated with a phosphorylation assay of exogenous substrates. It involved an increase in the Vmax of the enzyme-catalyzed phosphotransfer reaction. No change was observed in the Km (substrate). A causal relationship between tyrosine autophosphorylation and activation of the kinase activity was proved by (i) the kinetic agreement between autophosphorylation and kinase activation, (ii) the overlapping dose-response relationship for ATP, (iii) the specificity for ATP of the activation process, (iv) the phosphorylation of tyrosine residues only, in the Met protein, in the activation step, (v) the linear dependence of the activation from the input of enzyme assayed, and (vi) the reversal of the active state by phosphatase treatment. Autophosphorylation occurred predominantly on a single tryptic peptide, most likely via an intermolecular reaction. The structural features responsible for this positive modulation of kinase activity were all contained in the 45-kDa intracellular moiety of the Met protein.
Therapeutic Potential of Tacrolimus on Acute Myocardial Infarction in Minipigs: Analysis with Serial Cardiac Magnetic Resonance and Changes at Histological and Protein Levels

This study investigates the therapeutic potential of intracoronary tacrolimus against acute myocardial infarction (AMI) in minipigs with serial cardiac magnetic resonance (CMR) and changes at histological and protein levels. Twelve minipigs subjected to permanent left anterior descending artery ligation were randomized as tac-treated group (n = 6, with intracoronary tacrolimus treatment) and controls (n = 6). CMR with cine and late gadolinium enhancement (LGE) studies were performed on postoperative days 2, 5, and 21. There were no significant differences in left ventricular function (LVF), contractility, and LGE between the two groups on day 2. On day 5, the tac-treated group showed a significantly higher ejection fraction, smaller infarct, and lower day-5/day-2 infarct ratio than controls. On day 21, the controls demonstrated further deterioration of LVF and infarct. Contrastingly, the tac-treated animals demonstrated preservation of LVF, contractility, significantly smaller infarct, and lower day-21/day-2 infarct ratios compared with those on day 5 and controls. The in vivo CMR results were correlated with in vitro findings on histology, immunostaining, and Western blotting which revealed significantly less fibrosis, higher vascularities, less CD68+ and CD40+ inflammatory cells, lower expressions of inflammatory (MMP-9, NF-κB, and TNF-α), and apoptotic (Bax, Caspase-3, c-PARP) biomarkers, respectively, in tac-treated AMI minipigs than controls.
UvA-DARE ( Digital Academic Repository ) Clinical pharmacology in leishmaniasis : treatment optimization of a neglected disease

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PERBEDAAN PERILAKU PENCARIAN INFORMASI, PENGETAHUANKESEHATAN REPRODUKSI DAN PERILAKU SEKSUAL REMAJASEKOLAH LANJUTAN TINGKAT ATAS (SLTA) NEGERI DAN SWASTA DIKABUPATEN SUKOHARJO

Sukoharjo sebagai kabupaten peralihan antara kota dan desa sangat memungkinkan masuknya arus informasi yang berkembang sehingga dapat mempengaruhi perilaku pencarian informasi, pengetahuan dan perilaku seksual remaja SLTA Negeri dan Swasta. Penelitian ini bertujuan untuk mengetahui gambaran dan perbedaan perilaku pencarian informasi, pengetahuan kesehatan reproduksi, dan perilaku seksual remaja antara SLTA Negeri dan Swasta di Kabupaten Sukoharjo. Metode penelitian ini adalah studi observasional dengan rancangan cross sectional. Subjek dalam penelitian ini adalah siswa SMA Negeri I dan SMK Tamansiswa Sukoharjo. Populasi penelitian sebanyak 1223 siswa SMA Negeri dan 830 SMA Swasta. Sampel sebanyak 172 siswa yang terdiri dari 86 pada masing-masing SMA yang meliputi kelas X dan XI dan diambil dengan teknik simple random sampling. Hasil penelitian menunjukkan tidak ada perbedaan perilaku pencarian informasi remaja SLTA Negeri dan Swasta di Kabupaten Sukoharjo (p=0,279), yaitu sama-sama kurang buruk. Terdapat perbedaan pengetahuan (p=0,033) dan perilaku seksual remaja (p=0,001) SLTA Negeri dan Swasta di Kabupaten Sukoharjo. Remaja SLTA Negeri memiliki pengetahuan dan perilaku seksual yang lebih baik dari pada SLTA Swasta.
Mobile and Electronic Commerce Systems and Technologies

The emergence of wireless and mobile networks has made possible the introduction of electronic commerce to a new application and research subject: mobile commerce. Understanding or constructing a mobile or an electronic commerce system is an arduous task because the system involves a wide variety of disciplines and technologies and the technologies are constantly changing. To facilitate understanding and constructing such a system, this article divides the system into six components: (i) applications, (ii) client computers or devices, (iii) mobile middleware, (iv) wireless networks, (v) wired networks, and (vi) host computers. Elements in these components specifically related to the subject are described in detail and lists of current technologies for component construction are discussed. Another important and complicated issue related to the subject is the mobile or electronic commerce application programming. It includes two types of programming: client-side and server-side programming, which will be introduced too.
Electrolytic ablation as an adjunct to liver resection: experimental studies of predictability and safety

Combined liver resection and local ablation may offer the only chance of cure to patients with liver metastases who are presently deemed unresectable because of a single awkwardly placed metastasis. By definition, such a metastasis is often close to a major vein. An ablative technique is needed that is both predictable and safe in such a circumstance.
PSD-95 Uncouples Dopamine–Glutamate Interaction in the D1/PSD-95/NMDA Receptor Complex

Classical dopaminergic signaling paradigms and emerging studies on direct physical interactions between the D1 dopamine (DA) receptor and the NMDA glutamate receptor predict a reciprocally facilitating, positive feedback loop. This loop, if not controlled, may cause concomitant overactivation of both D1 and NMDA receptors, triggering neurotoxicity. Endogenous protective mechanisms must exist. Here, we report that PSD-95, a prototypical structural and signaling scaffold in the postsynaptic density, inhibits D1–NMDA receptor subunit 1 (NR1) NMDA receptor association and uncouples NMDA receptor-dependent enhancement of D1 signaling. This uncoupling is achieved, at least in part, via a disinhibition mechanism by which PSD-95 abolishes NMDA receptor-dependent inhibition of D1 internalization. Knockdown of PSD-95 immobilizes D1 receptors on the cell surface and escalates NMDA receptor-dependent D1 cAMP signaling in neurons. Thus, in addition to its role in receptor stabilization and synaptic plasticity, PSD-95 acts as a brake on the D1–NMDA receptor complex and dampens the interaction between them.
Journal of Emerging Trends in Computing and Information Sciences Modeling of Orthogonal Frequency Division Multiplexing (ofdm) for Transmission in Broadband Wireless Communications

Orthogonal Frequency Division Multiplexing (OFDM) is a multi carrier modulation technique that provides high bandwidth efficiency because the carriers are orthogonal to each other and multiple carriers share the data among themselves. The main advantage of this transmission technique is its robustness to channel fading in wireless communication environment. This paper investigates the effectiveness of OFDM and assesses its suitability as a modulation technique in wireless communications. Several of the main factors affecting the performance of a typical OFDM system are considered and they include multipath delay spread, channel noise, distortion (clipping), and timing requirements. The core processing block and performance analysis of the system is modeled using Matlab.
Using independent components analysis to calculate intravascular contrast agent concentration in prostate cancer

Dynamic contrast enhanced MRI combined with Pharmacokinetic (PK) modeling of prostate tissue provides information about its microenvironment and vascular permeability. A fundamental step in PK analysis is measuring the intravascular contrast agent concentration or the arterial input function (AIF). In this study a method is introduced to calculate the intravascular concentration in the prostate tissue using an adaptive complex independent components analysis (ACICA) method and to correct this curve for the early phases of the passage of the contrast agent through tumor vasculature. The results are applied to DCE-MR images of the prostate of a 70 year old prostate cancer patient and the calculated Ktrans map is examined using tumor location defined by multi-parametric MRI. The results show that there is a high Ktrans value in the region in the peripheral zone of the prostate that was hypo-intense in both apparent diffusion coefficient map and T2-weighted MRI. Moreover the results are compared with the parameters derived using a large artery and also corrected artery as the intravascular concentration curve.
A Lower Bound for Dynamic Approximate Membership Data Structures

An approximate membership data structure is a randomized data structure for representing a set which supports membership queries. It allows for a small false positive error rate but has no false negative errors. Such data structures were first introduced by Bloom in the 1970's, and have since had numerous applications, mainly in distributed systems, database systems, and networks. The algorithm of Bloom is quite effective: it can store a set $S$ of size $n$ by using only $\approx 1.44 n \log_2(1/\epsilon)$ bits while having false positive error $\epsilon$. This is within a constant factor of the entropy lower bound of $n \log_2(1/\epsilon)$ for storing such sets. Closing this gap is an important open problem, as Bloom filters are widely used is situations were storage is at a premium. Bloom filters have another property: they are dynamic. That is, they support the iterative insertions of up to $n$ elements. In fact, if one removes this requirement, there exist static data structures which receive the entire set at once and can almost achieve the entropy lower bound, they require only $n \log_2(1/\epsilon)(1+o(1))$ bits. Our main result is a new lower bound for the memory requirements of any dynamic approximate membership data structure. We show that for any constant $\epsilon>0$, any such data structure which achieves false positive error rate of $\epsilon$ must use at least $C(\epsilon) \cdot n \log_2(1/\epsilon)$ memory bits, where $C(\epsilon)>1$ depends only on $\epsilon$. This shows that the entropy lower bound cannot be achieved by dynamic data structures for any constant error rate. In fact, our lower bound holds even in the setting where the insertion and query algorithms may use shared randomness, and where they are only required to perform well on average.
The impact of the built environment on health across the life course: design of a cross-sectional data linkage study

Introduction The built environment is increasingly recognised as being associated with health outcomes. Relationships between the built environment and health differ among age groups, especially between children and adults, but also between younger, mid-age and older adults. Yet few address differences across life stage groups within a single population study. Moreover, existing research mostly focuses on physical activity behaviours, with few studying objective clinical and mental health outcomes. The Life Course Built Environment and Health (LCBEH) project explores the impact of the built environment on self-reported and objectively measured health outcomes in a random sample of people across the life course. Methods and analysis This cross-sectional data linkage study involves 15 954 children (0–15 years), young adults (16–24 years), adults (25–64 years) and older adults (65+years) from the Perth metropolitan region who completed the Health and Wellbeing Surveillance System survey administered by the Department of Health of Western Australia from 2003 to 2009. Survey data were linked to Western Australia's (WA) Hospital Morbidity Database System (hospital admission) and Mental Health Information System (mental health system outpatient) data. Participants’ residential address was geocoded and features of their ‘neighbourhood’ were measured using Geographic Information Systems software. Associations between the built environment and self-reported and clinical health outcomes will be explored across varying geographic scales and life stages. Ethics and dissemination The University of Western Australia's Human Research Ethics Committee and the Department of Health of Western Australia approved the study protocol (#2010/1). Findings will be published in peer-reviewed journals and presented at local, national and international conferences, thus contributing to the evidence base informing the design of healthy neighbourhoods for all residents.
A Comparison between Chemical Synthesis Magnetite Nanoparticles and Biosynthesis Magnetite

The preparation of Fe3O4 from ferrous salt by air in alkaline aqueous solution at various temperatures was proposed. The synthetic magnetites have different particle size distributions. We studied the properties of the magnetite prepared by chemical methods compared with magnetotactic bacterial nanoparticles. The results show that crystallite size, morphology, and particle size distribution of chemically prepared magnetite at 293 K are similar to biosynthesis of magnetite. The new preparation of Fe3O4 helps to explain the mechanism of formation of magnetosomes in magnetotactic bacteria. The products are characterized by X-ray powder diffraction (XRD), infrared (IR) spectra, vibrating sample magnetometry (VSM), and scanning electron microscopy (SEM).
Modeling and building software product lines with eclipse

Software product line development (SPLD) can reduce the overall software production costs, but imposes extra complexity on the development process. Dealing with the commonalities and variabilities of the product variants and with the flexible software archiecture makes product line development a real challenge. Developers can only be successful with adequate tool support for product line development, which is still not the ”state of the art”. The demonstration shows the integration of software product line modeling based on feature models into the popular integrated development environment Eclipse. We will demonstrate that a flexible product line architecture can be build by using the modeling capabilities provided by pure::variants, an eclipse plugin for software product line development. The plugin covers all steps of product line development from requirements and variability analysis to product generation. Extended feature models are used for modeling of problem domain. Family models are used to represent the variable architecture of product line solution domains independent of the programming or modeling languages used for product line implementation. Along some concrete examples from the domain of embedded software product lines we will make a round-trip through all steps of the development from domain analysis to product deployment and demonstrate how pure::variants facilitates the entire process. We will show how features are used to model problem domains, how product line architectures are connected with domain models and finally how to integrate concepts of model driven development into the process of product derivation.
Intelligent exposure determination for high quality HDR image generation

High dynamic range (HDR) image generation had been studied for years. Due to the expense and rareness of HDR cameras, many works try to generate HDR images using several low dynamic range (LDR) images with different exposure conditions. To ensure high-quality HDR image generation, details of the scene should be retained in different LDR images and the exposure parameters of LDR image should be chosen carefully. In this paper, we propose a technique to dynamically determine the suitable exposure parameter for LDR images according to the property of each scene to be captured. Experimental results reveal that better HDR images are always generated with the LDR images captured by the determined exposure, compared to those created by the method with fixed exposures.
Temporal Variation of Wood Density and Carbon in Two Elevational Sites of Pinus cooperi in Relation to Climate Response in Northern Mexico

Forest ecosystems play an important role in the global carbon cycle. Therefore, understanding the dynamics of carbon uptake in forest ecosystems is much needed. Pinus cooperi is a widely distributed species in the Sierra Madre Occidental in northern Mexico and future climatic variations could impact these ecosystems. Here, we analyze the variations of trunk carbon in two populations of P. cooperi situated at different elevational gradients, combining dendrochronological techniques and allometry. Carbon sequestration (50% biomass) was estimated from a specific allometric equation for this species based on: (i) variation of intra-annual wood density and (ii) diameter reconstruction. The results show that the population at a higher elevation had greater wood density, basal area, and hence, carbon accumulation. This finding can be explained by an ecological response of trees to adverse weather conditions, which would cause a change in the cellular structure affecting the within-ring wood density profile. The influence of variations in climate on the maximum density of chronologies showed a positive correlation with precipitation and the Multivariate El Niño Southern Oscillation Index during the winter season, and a negative correlation with maximum temperature during the spring season. Monitoring previous conditions to growth is crucial due to the increased vulnerability to extreme climatic variations on higher elevational sites. We concluded that temporal variability of wood density contributes to a better understanding of environmental historical changes and forest carbon dynamics in Northern Mexico, representing a significant improvement over previous studies on carbon sequestration. Assuming a uniform density according to tree age is incorrect, so this method can be used for environmental mitigation strategies, such as for managing P. cooperi, a dominant species of great ecological amplitude and widely used in forest industries.