Miracle-dz/UniFAR-FTUs huggingface dataset:
Learning in Projects, Remembering in Networks?

This paper seeks to contrast two opposing logics of project-based learning. Accumulation and modularization of knowledge denote the key imperatives of a learning logic that is exemplified by the software ecology in Munich. Learning is geared towards moving from ‘one-off’ to repeatable solutions. This cumulative logic is juxtaposed with a discontinuous learning regime that is driven by the maxims of originality and creativity. ‘Learning by switching’ here signifies the emblematic knowledge practice that is exemplified by the London advertising ecology. The paper explores these learning modes by subsequently exploring processes of learning and forgetting within and between the core team, the firm, and the epistemic community tied together for the completion of a specific project. In addition, the paper also directs attention to more diffuse learning processes in an awareness space that extends beyond and beneath the actual production ties. Instead of mapping the awareness space along a simplistic scalar nesting of network density and knowledge types (reduced to the notorious global vs local dichotomy), the paper proposes a differentiation that primarily involves different social and communicative logics. Whereas communality signifies lasting and intense ties, sociality signifies intense and yet ephemeral relations and connectivity indicates transient and weak networks.
Numerical variations and spontaneous malformations in the early embryos of the Korean salamander, Hynobius leechii, in the farmlands of Korea

Embryo sacs of the Korean salamander, Hynobius leechii, were collected from nine farmlands in Gyeongsangnam‐Do, Korea, in early spring of 2002 and 2004. The variations in the number of embryos within each embryo sac and the mortality and abnormality rates among the embryos were investigated. We also analyzed the patterns of spontaneous embryonic malformations and the residual chemicals in the soil of the habitats using multiple‐residue GC/MS. A total of 79,195 embryos were obtained from 1933 embryo sacs. There were regional variations in the length of individual embryo sacs and the number of embryos in each. The longest embryo sac averaged by region measured 20.67 (cm) ± 3.51 and was obtained from 2‐Banseong in 2002. Of the embryos collected, 13.71% either died or stopped developing, and 3.54% of the hatched embryos developed abnormally; the latter were classified according to the patterns of malformation. External gill dysplasia was the most frequent malformation, and caudal dysplasia, abdominal blisters, and dysplasia of the fin were also observed frequently. Histopathological analysis showed neural tube abnormalities, acrania, curved notochords, thyroid teratoma, and various other kinds of endodermal developmental abnormalities. In the analysis of the residual pesticides in the soil, carbofuran, endosulfan‐sulfate, and endosulfan‐β were detected in the regions with high mortality and malformation rates. These results indicate that various agricultural chemicals and other unknown factors may cause the aforementioned forms of spontaneous malformations in the embryos of Hynobius leechii. © 2009 Wiley Periodicals, Inc. Environ Toxicol 25: 533–544, 2010.
Advancing the case for microbial conservation

The majority of the biomass and biodiversity of life on the Earth is accounted for by microbes. They play pivotal roles in biogeochemical cycles and harbour novel metabolites that have industrial uses. For these reasons the conservation of microbial ecosystems, communities and even specific taxa should be a high priority. We review the reasons for including microorganisms in conservation agenda. We discuss some of the complications in this endeavour, including the unresolved argument about whether microorganisms have intrinsic value, which influences some of the noninstrumental motivations for their conservation and, from a more pragmatic perspective, exactly what it is that we seek to conserve (microorganisms, their habitats or their gene pools). Despite complications, priorities can be defined for microbial conservation and we provide practical examples of such priorities.
Zn (II) Removal from River Water Samples of Sembrong, Johor State, Malaysia by Electrokinetic Remediation

Heavy metals pollution has become one of the most serious environmental problems today. The treatment of heavy metals is of special concern due to their recalcitrance and persistence in the environment. Even many physical, chemical and biological treatment processes have been proposed to remove heavy metals from river water, the use of these treatment processes are not efficient and relatively costly. This study focused on the potential application of electrokinetic (EK) remediation in Sembrong River water to remove zinc (Zn2+). The physicochemical and biological parameters and water quality index (WQI) of Sembrong River water was characterized. The electrokinetic remediation experiments were performed by controlling pH, and electric density on voltage were observed and investigated. The results indicated that all physicochemical and biological parameters of Sembrong River complied with the standard discharged limit set by the Department of Environment (DOE). However, suspended solids (SS) and pH can be categorized as Class III according to INWQS. The best performance of 88% efficiency of zinc can be achieved EK experiment run at a fixed voltage of 30 V at pH 5.14 after 60 min of the process operate. This technology may be proposed for faster and eco-friendly removal of heavy metals in the environment.
Insights into the rise in HIV infections, 2001 to 2008: a Bayesian synthesis of prevalence evidence

Objective:To estimate trends in prevalence of HIV infection, undiagnosed and total, among adults aged 15–44 years in England and Wales since 2001. Design:Multiple surveillance systems and survey data are available to inform different aspects of the HIV epidemic in England and Wales. To coherently and consistently combine this information to estimate trends in HIV prevalence, we apply a multiparameter evidence synthesis in a Bayesian statistical framework. Methods:The study population is stratified by exposure group and region of residence. We synthesize data from behavioural and community surveys, unlinked anonymous seroprevalence surveys, and an annual survey of individuals with diagnosed HIV infection. Prevalence estimates are given with 95% credible intervals. Results:The estimated number of prevalent HIV infections in 15–44-year-olds has increased from 32 400 (29 600–35 900) in 2001 to 54 500 (50 500–59 100) in 2008, corresponding to an estimated prevalence of 1.5 per 1000 (1.4–1.7) rising to 2.4 per 1000 (2.3–2.6) in 2008. A rise in prevalence of diagnosed infection contributes substantially to the increase. There is no evidence of a statistically significant decrease in the prevalence of undiagnosed infection. The proportion of infections that are diagnosed has therefore also increased. Conclusion:Although the increase in the proportion of infections that are diagnosed is encouraging, the rise in HIV prevalence and lack of evidence of a decrease in prevalence of undiagnosed infection suggest that diagnosis rates are not high enough to reduce the pool of individuals unaware of their infection and that new infections must be occurring.
Management of Tetralogy of Fallot with Pulmonary Atresia

Tetralogy of Fallot with Pulmonary Atresia is an extreme form of tetralogy characterized by absence of flow from the right ventricle to the pulmonary arteries. Pulmonary blood flow is derived from a variety of sources, including native pulmonary artery branches and aorto-pulmonary collaterals with significant variability from patient to patient. Management must therefore be individualized to each patient's anatomy and physiology. Cardiac catheterization plays a crucial diagnostic and therapeutic role in this group of patients. This article is a concise review of the spectrum of anatomic variability seen in this lesion with an emphasis on diagnostic and therapeutic catheterization . It also highlights our staged surgical approach to this lesion and provides data on long-term outcome after complete intracardiac repair.
ERFORMANCE A NALYSIS OF S UPPLY C HAINS

Since supply chain management is one of the most important management practices that impacts the financial results of services and companies, it is important to optimize and analyze the performance of supply chains. Simulation provides a way to get closer to real life complex situations and uses less simplifications and assumptions than needed with analytical solutions. This paper proposes the application of Monte Carlo simulation based optimization and sensitivity analysis of supply chains to handle modeling uncertainties and stochastic nature of the processes and to extract and visualize relationship among the decision variables and the Key Performance Indicators. In this article the authors utilize their own interactive simulator, SIMWARE, capable to simulate complex multi-echelon supply chains based on simple configurable connection of building blocks. They introduce a sensitivity analysis technique to extract and visualize the relationships among the decision variables and key performance indicators. The proposed robust sensitivity analysis is based on an improved method used to extract gradients from Monte Carlo simulation. The extracted gradients (sensitivities) are visualized by a technique developed by the authors. The results illustrate that the sensitivity analysis tool is flexible enough to handle complex situations and straightforward and simple enough to be used for decision support.
Role of dendritic cells in peanut allergy

ABSTRACT Introduction: The prevalence of peanut allergy (PA) has increased, affecting approximately 1.1% of children in Western countries. PA causes life-threatening anaphylaxis and frequently persists for life. There are no standardized curative therapies for PA, and avoidance of peanuts remains the main therapeutic option. A better understanding of the pathogenesis of PA is essential to identify new treatment strategies. Intestinal dendritic cells (DCs) are essential in the induction and maintenance of food tolerance because they present dietary allergens to T cells, thereby directing subsequent immune responses. Areas covered: In this review, we discuss the factors related to the acquisition of oral tolerance to peanut proteins. We focus on intestinal DC-related aspects, including the latest advances in the biology of intestinal DC subtypes, effect of tolerance-inducing factors on DCs, effect of dietary components on oral tolerance, and role of DCs in peanut sensitization. Expert commentary: Given the increasing prevalence of PA, difficulty of avoiding peanut products, and the potentially serious accidental reactions, the development of novel therapies for PA is needed. The ability of DCs to trigger tolerance or immunity makes them an interesting target for new treatment strategies against PA.
Comparing the diagnostic efficacy of full field digital mammography with digital breast tomosynthesis using BIRADS score in a tertiary cancer care hospital

Abstract Introduction: Breast cancer is one of the leading cancers in females worldwide, and its incidence has been rising at an exponential pace in the last 10 years even in India. Mammography has been the mainstay for detection of breast cancer over decades and has gradually advanced from screen film to full-field digital mammography. Recently, tomosynthesis has evolved as an advanced imaging investigation for early diagnosis of breast lesions in both diagnostic and screening settings. Aim of Study: To compare and evaluate the impact of digital breast tomosynthesis (DBT) compared to full-field digital mammography (FFDM) in the interpretation of BIRADS score in both diagnostic and screening settings. Settings and Design: A 1-year prospective longitudinal study was conducted in the Department of Radio-diagnosis in our institute using Hologic Selenia Dimensions for mammography as well as tomosynthesis. Materials and Methods: One hundred women known or suspected (opportunistic screening) for breast cancer were evaluated either with FFDM alone or both FFDM and DBT. Sensitivity, specificity, positive predictive value, negative predictive value, and P value were used to assess the various diagnostic criteria in our study. Results: Addition of DBT to FFDM results in a statistically significant increase in the sensitivity, specificity, and positive predictive value, and a statistically significant decrease in the false positive rates. Similar results were noted in both diagnostic and screening cases. It was observed that, in most cases, i.e. a total of 47, DBT did not change the BIRADS scoring; however, its addition increased the diagnostic confidence. BIRADS was upgraded and downgraded in 14 and 31 cases, respectively, with the addition of DBT to FFDM. New lesions were seen with addition of DBT to FFDM in 8 cases. Conclusion: Addition of DBT to FFDM results in increase in sensitivity, specificity, positive predictive value, and a statistically significant decrease in false positive rates in both diagnostic and screening cases. As addition of tomosynthesis results in a significant decrease in recall rate, it should be added, at least, in all screening mammography programs.
Factorial Experimental Planning Applied for Evaluated Effect of Matrix Temperature and Screw Rotation Speed of Extrusion in Mechanical Properties and Dimensional Changes in PVC Pipes

This study evaluated the effects of temperature and speed screw rotation of rigid recycled PVC pipe extrusion process on mechanical properties and dimensional variation. In developing the experiments were used the factorial design method type 2k. Were studied the influence of process variables on the properties of impact resistance, dimensional change and tensile strength of PVC pipe. From this study, it was possible to define the best extrusion process conditions with a point of view on the best properties of PVC pipes. The results indicated that the screw rotation has a significant influence on the impact property. For the dimensional variation, the extrusion temperature had a significant influence. There is no significant statistical values for the tensile strength in the studied variables.
A High-Efficiency Induction of Dopaminergic Cells from Human Umbilical Mesenchymal Stem Cells for the Treatment of Hemiparkinsonian Rats

The success rate in previous attempts at transforming human umbilical mesenchymal stem cells (HUMSCs) isolated from Wharton's jelly of the umbilical cord into dopaminergic cells was a mere 12.7%. The present study was therefore initiated to establish a more effective procedure for better yield of dopaminergic cells in such transformation for more effective HUMSC-based therapy for parkinsonism. To examine, in vitro, the effects of enhanced Nurr1 expression in HUMSCs on their differentiation, cells were processed through the three-stage differentiation protocol. The capacity of such cells to synthesize and release dopamine was measured by HPLC. The therapeutic effects of Nurr1-overexppressed HUMSCs were examined in 6-hydroxydopamine-lesioned rats by quantification of rotations in response to amphetamine. Enhanced Nurr1 expression in HUMSCs promoted the transformation into dopaminergic cells in vitro through stepwise culturing in sonic hedgehog, fibroblast growth factor-8, and neuron-conditioned medium. The success rate was about 71%, as determined by immunostaining for tyrosine hydroxylase and around 94 nM dopamine synthesis (intracellular and released into the culture medium), as measured by HPLC. Additionally, transplantation of such cells into the striatum of hemiparkinsonian rats resulted in improvement of their behavioral deficits, as indicated by amphetamine-evoked rotation scores. Viability of the transplanted cells lasted for at least 3 months as verified by positive staining for tyrosine hydroxylase. Nurr1, FGF8, Shh, and NCM can synergistically enhance the differentiation of HUMSCs into dopaminergic cells and may pave the way for HUMSC-based treatments for Parkinson's disease.
Model‐driven design of a minimal medium for Akkermansia muciniphila confirms mucus adaptation

The abundance of the human intestinal symbiont Akkermansia muciniphila has found to be inversely correlated with several diseases, including metabolic syndrome and obesity. A. muciniphila is known to use mucin as sole carbon and nitrogen source. To study the physiology and the potential for therapeutic applications of this bacterium, we designed a defined minimal medium. The composition of the medium was based on the genome‐scale metabolic model of A. muciniphila and the composition of mucin. Our results indicate that A. muciniphila does not code for GlmS, the enzyme that mediates the conversion of fructose‐6‐phosphate (Fru6P) to glucosamine‐6‐phosphate (GlcN6P), which is essential in peptidoglycan formation. The only annotated enzyme that could mediate this conversion is Amuc‐NagB on locus Amuc_1822. We found that Amuc‐NagB was unable to form GlcN6P from Fru6P at physiological conditions, while it efficiently catalyzed the reverse reaction. To overcome this inability, N‐acetylglucosamine needs to be present in the medium for A. muciniphila growth. With these findings, the genome‐scale metabolic model was updated and used to accurately predict growth of A. muciniphila on synthetic media. The finding that A. muciniphila has a necessity for GlcNAc, which is present in mucin further prompts the adaptation to its mucosal niche.
Selection of Filtration Methods in the Analysis of Motion of Automated Guided Vehicle

Abstract In this article the issues related to mapping the route and error correction in automated guided vehicle (AGV) movement have been discussed. The nature and size of disruption have been determined using the registered runs in experimental studies. On the basis of the analysis a number of numerical runs have been generated, which mapped possible to obtain runs in a real movement of the vehicle. The obtained data set has been used for further research. The aim of this paper was to test the selected methods of digital filtering on the same data set and determine their effectiveness. The results of simulation studies have been presented in the article. The effectiveness of various methods has been determined and on this basis the conclusions have been drawn.
Truths and myths about the mushroom Agaricus blazei

O cogumelo Agaricus blazei Murrill foi descoberto na cidade de Piedade, Estado de Sao Paulo, Brasil, e enviado para o Japao para o estudo das suas propriedades medicinais. Com a descoberta das suas propriedades antitumorais, comprovadas em cobaias, o Japao passou a importar esse cogumelo do Brasil. Devido ao seu elevado preco no mercado internacional, muitas empresas e produtores rurais passaram a buscar nesse cogumelo uma nova alternativa de renda. Diante de um interesse tao repentino, nao houve tempo para que a comunidade cientifica pesquisasse o assunto, de maneira que a tecnologia de cultivo e ainda muito empirica. Alem disso, existem informacoes contraditorias acerca da classificacao desse cogumelo e as suas propriedades antitumorais ainda precisam ser confirmadas em seres humanos.
Explaining Viewers' Emotional, Instrumental, and Financial Support Provision for Live Streamers

On live streams, viewers can support streamers through various methods ranging from well-wishing text messages to money. In this study (N=230) we surveyed viewers who had given money to a streamer. We identified six motivations for why they gave money to their favorite live streamer. We then examined how factors related to viewer, streamer, and viewer-streamer interaction were associated with three forms of social support provision: emotional, instrumental, and financial support. Our main findings are: parasocial relationship was consistently correlated with all three types of social support, while social presence was only related with instrumental and financial support; interpersonal attractiveness was associated with emotional and instrumental support and lonely people were more likely to give instrumental support. Our focus on various types of social support in a live streaming masspersonal platform adds a more detailed understanding to the existing literature of mediated social support. Furthermore, it suggests potential directions for designing more supportive and interactive live streaming platforms.
Customization of laboratory for radiant cooling ceiling measurements

In this article is examine Laboratory of Environmental Engineering at Faculty of applied informatics under Tomas Bata University in Zlin. This laboratory is performing standardized test of special HVAC equipments. This article describes newly made customization for measuring radiant cooling ceilings. Firstly is described previous situation which is concluded by necessary changes. It is mentioned energy supplies and newly made connection for cooling ceilings. Whole article is sum up by description of samples on which would be done verification of measurement space and methodology.
HEPATITIS C VIRUS IN IRAN: EPIDEMIOLOGY OF AN EMERGING INFECTION

Hepatitis C infection has come to the top of virus-induced liver diseases in many parts of the world. In Iran, it seems that its prevalence in general population is less than 1%, which is much lower than in most of the regional countries. However, the infection is emerging mostly due to problem of intravenous drug abuse and needle-sharing in the country. On the other hand, an increase in number of centers providing hemodialysis and transfusion facilities for hemoglobinopathies generated new sources and susceptible populations in Iran. This article aims to summarize available data of Iran and to compare them with those of similar countries to find better preventive means.
Function learning with local linear regression models: An analysis based on discrepancy

In this work local linear regression models are introduced and analyzed in the context of empirical risk minimization (ERM) for function learning. This kind of models can be seen as a more sophisticated version of classic kernel smoothing models, based on the principle of local estimation. In particular, we analyze the conditions under which consistency of the ERM procedure is guaranteed, pointing out assumptions on the way the input space is sampled to obtain the observation data. This allows to extend the tractation to the case where the choice of the training set is part of the learning process. To this purpose, a choice of the observation points based on low-discrepancy sequences, a family of sampling methods commonly employed for efficient numerical integration, is analyzed. Simulation results involving two different examples of function learning are provided.