Miracle-dz/UniFAR-FTUs huggingface dataset:
Relations entre les perceptions de soi, la motivation d’accomplissement et la pratique d’activité physique des personnes âgées.

L'objet de la presente these etait d'examiner les relations entre les perceptions de soi, la motivation d'accomplissement et la pratique d'activite physique des personnes âgees. Une premiere etude menee dans une perspective dynamique (Ninot et al., 2004) a montre que l'estime de soi et les perceptions du soi physique chez les sujets âges, presentaient un niveau plus bas, une instabilite plus importante, comparees aux perceptions de soi de jeunes adultes, mais aussi une non-stationnarite des series temporelles. Le caractere labile de ces perceptions de soi etant demontre, une seconde etude a mis en evidence qu'une prise en charge en APA de sujets institutionnalises tres âges entrainait des changements positifs de leur estime globale de soi et de leurs perceptions de valeur physique, d'apparence physique et de competence sportive. Compte tenu de la mise en jeu de l'estime de soi dans les buts d'accomplissement (e.g., Wolfe & Crocker, 2002), les deux etudes suivantes ont consiste a valider un Questionnaire Francais des Buts d'Accomplissement pour le Sport et l'Exercice Physique (QFBASEP ; Riou et al., 2012) prenant en compte les evolutions conceptuelles recentes du modele en quatre buts d'Elliot et Murayama (2008). L'instrument ainsi cree nous a permis, dans une cinquieme etude, de demontrer qu'une prise en charge en APA, pratiquee dans un climat motivationnel de maitrise entrainait une reduction de l'implication des personnes âgees institutionnalisees dans les buts de maitrise-evitement habituellement consideres comme des reponses mal-adaptatives a la menace que constitue la confrontation au declin de ses propres capacites (Elliot, 2005). Enfin, une sixieme etude a permis de montrer qu'une combinaison de proprietes relatives aux buts d'accomplissement identifiees par Gernigon et collaborateurs (Gernigon, 2013 ; Gernigon et al., 2012) predisait la participation a des activites physiques des personnes âgees. En conclusion, l'etude des facteurs psycho-sociaux de la pratique d'activites physiques a permis de determiner les roles respectifs de l'estime de soi et des perceptions du soi physique d'une part, et de la motivation d'accomplissement d'autre part, dans l'engagement des personnes âgees dans des comportements actifs physiquement. Nous avons demontre que des pratiques d'APA encadrees ouvrent la perspective d'un processus de reengagement dans des comportements actifs et peuvent constituer le point de depart de l'inversion du processus de deconditionnement (Prefaut & Ninot, 2009).
Through Silicon Via (TSV) redundancy - a high reliability, networking product perspective

3-D, stacked ICs offer a promising solution to speed, power and density requirements, as the industry strives to scale to Moore's Law. Through Silicon Vias (TSV) are integral parts to 3-D stacked ICs. TSVs shorten interconnects between logic elements, thus reducing power while increasing performance. TSVs may comprise a significant portion (both logically and physically) of the 3D die stack. It's likely that tens of thousands of TSVs will be incorporated into a 3D die stack. Even though it's widely considered that the TSV yield will be very high, the large number of TSVs still presents a significant risk, given that it is difficult to have 100% test coverage, and a single TSV failure in the field can invalidate an entire die stack (multiplying yield loss by the number of die in the stack). Reliability of TSVs is not clearly understood yet and can also present significant field issues. TSV redundancy has been proposed as a way to mitigate the risk of TSV failure in the stack. This paper will look at published work on TSV redundancy, as well as standards and practical work. The paper will take a practical perspective, taking into account: cost, design (performance), and implementation/deployment considerations. The paper will conclude by providing guidelines and recommendations, which can be used to develop a TSV redundancy strategy at the device level for high reliability networking applications.
Plan recognition in intrusion detection systems

To be effective, current intrusion detection systems (IDSs) must incorporate artificial intelligence methods for plan recognition. Plan recognition is critical both to predicting the future actions of attackers and planning appropriate responses to their actions. However network security places a new set of requirements on plan recognition. We present an argument for including plan recognition in IDSs and an algorithm for conducting plan recognition that meets the needs of the network security domain.
The toxic dinoflagellate Alexandrium ostenfeldii promotes incapacitation of the calanoid copepods Eurytemora affinis and Acartia bifilosa from the northern Baltic Sea

Dense localized blooms of the toxic dinoflagellate Alexandrium ostenfeldii are a recent phenomenon in the low salinity waters of the Baltic Sea. This study reports results from laboratory experiments investigating the interaction between PSP toxin producing strains of A. ostenfeldii and two copepod species, Eurytemora affinis and Acartia bifilosa, from the northern Baltic Sea. Copepod grazing rates were studied by incubating the copepods with mixed cultures of A. ostenfeldii isolated from a bloom area. The effect of A. ostenfeldii on copepod condition and behavior was studied by exposing copepods to the mixed cultures and cell-free filtrates. Grazing on A. ostenfeldii cells was negligible for both copepod species. The 24 h incapacitation incubations indicated that the condition of both copepod species was negatively affected by the presence of A. ostenfeldii. The behavioral changes observed took place during the first hours of exposure to A. ostenfeldii cells, and little or no change was observed in the condition of the copepods after 6 h compared to 24 h. Similar observations were made for E. affinis incubated in cell-free filtrates of A. ostenfeldii, while the response of A. bifilosa was less pronounced. Our study shows that the copepods do not graze on A. ostenfeldii due to rapid behavioral disturbance and incapacitation by the algal cells and their exudates. This represents the first observation of a negative effect of the A. ostenfeldii on co-occurring biota in the northern Baltic Sea.
Insulitis and Diabetes in NOD Mice Reduced by Prophylactic Insulin Therapy

Intensive insulin therapy in patients with recently diagnosed insulin-dependent diabetes mellitus (IDDM) has been reported to result in a prolonged increase in endogenous insulin-secreting capacity. Because the clinical onset of IDDM occurs only after most insulinsecreting β-cells have been destroyed, we tested whether prophylactic insulin therapy might prevent IDDM in nonobese diabetic (NOD) mice. One hundred fourteen NOD mice were randomized at weaning into a protamine zinc pork insulin-treated (I) group or a placebo-treated (P) group given insulin diluent. All insulin treatments were adjusted to the maximum tolerable dosages and continued until 180 days of age. The cumulative IDDM frequency within the female I group was significantly less (3 of 34, 8%) than in female P controls (17 of 26, 65%; P < 0.0001). This beneficial effect was limited to females, however, because the frequency of IDDM in male I mice (3 of 32, 9%) was not significantly different from the frequency in male P controls (1 of 22, 5%; P < 0.5). Pancreatic histological examinations of nondiabetic animals revealed that insulin treatment resulted in significant reductions in islet cell inflammation and damage and improvements in insulin content. In summary, NOD mice given insulin therapy from weaning until 180 days of age had significantly lower frequencies of diabetes and pancreatic insulitis than sex-matched control littermates treated with insulin diluent. These results suggest that prophylactic insulin therapy to prevent IDDM in humans should be considered for clinical trials.
The role of corporate branding in a market driving strategy

The market orientation literature distinguishes between market driven and market driving approaches. Although, most of the companies provided as examples of the latter approach have strong corporate brands, the corporate brand and associated brand values have not previously been considered as a basis for market driving. We argue that the corporate brand provides a further source of the “leap” in customer value required for a market driving approach. Through a case study of Ikea we illustrate how the core values of the brand guide the behaviour and activities of internal stakeholders and relationships with external stakeholders, and explore the interactions between the global brand values and local market level activities.
A Model for the Analytical Definition of Multi-VDD , Multi-T Dynamic Tests in Nanometer Digital Circuits

semiconductor technologies requires the detection of dynamic faults, namely delay test. In addition, process variations must be taken into account, leading to the specification of acceptability windows and time slacks. In previous works, it has been demonstrated that parametric tests using variable power supply voltage (multi-V DD test) and temperature (multi-T test) can be rewardingly applied to production and lifetime test. In this paper, a simple analytical model to define those dynamic parametric tests and the resulting test strategy are presented. Faults are unrestrictedly defined to describe the impact of physical defects, system operation, process variations, un-modeled layout-dependent parasitics, etc. on the timing response of the Core Under Test (CUT) and modeled as variations of the load capacitances of logic gates with respect to their nominal values. Simulation results allow the capabilities of the proposed approach to be demonstrated.
TEI 2013 studio: motors and music

In this studio we present teaching material focused on dynamic force-feedback and sound synthesis for the learning of haptics. Using simple and low-cost tool sets that we have developed specifically for engaging interaction designers with the study of haptics, our aim is to advance the quality of haptics research and experimentation in the classroom. Using this studio opportunity to present what we have developed for design students, we aim to thereby advance the platform through effective learning.
Theory of electron band tails and the Urbach optical-absorption edge.

The density of states rho(E) in the tail for an electron in a correlated Gaussian random potential in three dimensions is constructed from first principles by means of a simple physical argument. This yields a linear exponential dependence of rho on E which, for reasonable values of the rms potential fluctuation and correlation length, spans many decades, and occupies most of the experimentally observable energy range. This is suggested as the origin of the fundamental Urbach optical-absorption edge.
Dipeptidyl peptidase-4 inhibition: insights from the bench and recent clinical studies

Purpose of review Atherosclerosis is the leading cause of death globally. The pathophysiology of atherosclerosis is not fully understood. Recent studies suggest dipeptidyl peptidase-4 (DPP4), a regulator of inflammation and metabolism, may be involved in the development of atherosclerotic diseases. Recent advances in the understanding of DPP4 function in atherosclerosis will be discussed in this review. Recent findings Multiple preclinical and clinical studies suggest DPP4/glucagon-like peptide-1 axis is involved in the development of atherosclerotic disease. However, several recent trials assessing the cardiovascular effects of DPP4 inhibition indicate enzymatic inhibition of DPP4 lacks beneficial effects on cardiovascular disease. Summary Catalytic inhibition of DPP4 with DPP4 inhibitors alters pathways that could favor cardioprotection. Glucagon-like peptide-1 receptor-independent aspects of DPP4 function may contribute to the overall neutral effects on cardiovascular outcome seen in the outcome trials.
The 2-Nitroimidazole EF5 Is a Biomarker for Oxidoreductases That Activate the Bioreductive Prodrug CEN-209 under Hypoxia

Purpose: Benzotriazine-N-oxide bioreductive prodrugs such as tirapazamine and its improved analogue CEN-209 (SN30000) have potential for exploiting hypoxia in tumors. Here, we test the hypothesis that the 2-nitroimidazole EF5, in clinical development for both immunohistochemical and positron emission tomography imaging of hypoxia, can detect not only hypoxia but also the one-electron reductases required for activation of these hypoxia-targeted prodrugs. Experimental Design: Aerobic and hypoxic covalent binding of [14C]-EF5 was determined in human tumor cell lines, including lines with overexpression of NADPH:cytochrome P450 oxidoreductase (CYPOR), and reductive metabolism of tirapazamine and CEN-209 by mass spectrometry. DNA damage response was measured by γH2AX formation. Bioreductive metabolism was modulated in HCT116 tumor xenografts by overexpression of CYPOR and breathing of hyperbaric oxygen or 10% oxygen. Results: Overexpression of CYPOR induced similar 2- to 4-fold increases in EF5 binding and metabolic reduction of tirapazamine and CEN-209 in SiHa and HCT116 cell lines, and similar enhancement of γH2AX formation. EF5 binding and metabolic reduction of the prodrugs were highly correlated in a panel of 14 hypoxic tumor cell lines. In HCT116 xenografts, CYPOR overexpression also significantly increased EF5 binding and CEN-209 reduction, and modification of tumor hypoxia caused similar changes to the bioreductive activation of both agents, resulting in a strong correlation between EF5 binding and CEN209-induced DNA damage (R2 = 0.68, P < 0.0001) at the individual tumor level. Conclusions: EF5 binding is a promising stratification biomarker for benzotriazine-N-oxide bioreductive prodrugs because of its potential for interrogating reductase activity as well as hypoxia in individual tumors. Clin Cancer Res; 18(6); 1684–95. ©2011 AACR.
A Test Collection for Evaluating Retrieval of Studies for Inclusion in Systematic Reviews

This paper introduces a test collection for evaluating the effectiveness of different methods used to retrieve research studies for inclusion in systematic reviews. Systematic reviews appraise and synthesise studies that meet specific inclusion criteria. Systematic reviews intended for a biomedical science audience use boolean queries with many, often complex, search clauses to retrieve studies; these are then manually screened to determine eligibility for inclusion in the review. This process is expensive and time consuming. The development of systems that improve retrieval effectiveness will have an immediate impact by reducing the complexity and resources required for this process. Our test collection consists of approximately 26 million research studies extracted from the freely available MEDLINE database, 94 review (query) topics extracted from Cochrane systematic reviews, and corresponding relevance assessments. Tasks for which the collection can be used for information retrieval system evaluation are described and the use of the collection to evaluate common baselines within one such task is demonstrated. The test collection is available at https://github.com/ielab/SIGIR2017-PICO-Collection.
Prevalence of Co-existing Endometrial Carcinoma in Patients with Preoperative Diagnosis of Endometrial Hyperplasia.

INTRODUCTION Endometrial hyperplasia has been associated with the presence of concomitant endometrial carcinoma. In this study, patients who were diagnosed with endometrial hyperplasia and had hysterectomy, determination of the incidence of endometrial cancer accompanying postoperatively and clinical parameters associated with cancer are aimed. MATERIALS AND METHODS Endometrial biopsies were taken from patients for various reasons and among them 158 patients diagnosed with endometrial hyperplasia from pathologic examination results were retrospectively evaluated. All of the patient's age, parity, weight, transvaginal ultrasound measured by endometrial thickness, concomitant systemic disease (diabetes, hypertension, hypothyroidism), tamoxifen use, hormone use and whether in reproductive age or menopause were all questioned. Patients who applied with endometrial cancer, their cervical stromal involvement, lymph node involvement, cytology positivity and omental metastases were examined. Patients were classified according to their stage and grade. Patients who had intraoperative frozen were re-evaluated. RESULTS Fifteen cases with preoperative endometrial hyperplasia diagnosed with endometrial cancer postoperatively, 2 cases had complex hyperplasia without atypia and 13 cases had complex atypical hyperplasia. The rate of preoperative hyperplasia with postoperative endometrial cancer was found to be 10.8% where by 15 cases of patients diagnosed with endometrial cancer postoperatively 11 cases were in postmenopausal period. In patients diagnosed with endometrial cancer according to their histologic types 14 cases had endometrioid adenocarcinoma while one patient with preoperative complex hyperplasia without atypia was diagnosed with serous papillary carcinoma postoperatively. Evaluation of stages in patients diagnosed with cancer, 7 cases of patients had stage IA, 7 cases of patients had stage IB, and 7 cases cases of patients with serous papillary carcinoma were evaluated as stage 3C. CONCLUSION The risk of endometrial cancer in patients diagnosed with endometrial hyperplasia especially endometrial hyperplasia ranges between 15% to 45% and among them 7.9%-51% are found to have myometrial inversion. Therefore, preoperative ultrasound and magnetic resonance imaging should be perfomed in patients diagnosed with complex atypical hyperplasia. Even intraoperative frozen section examination can provide useful information in selected cases.
Informed message update for iterative MIMO demapping and turbo decoding

In this paper, the iterative scheduling issue for multiple-input multiple-output (MIMO) systems with turbo codes is addressed based on the informed asynchronous scheduling, initially used for scheduling low-density parity-check (LDPC) decoding. For the iterative MIMO demapping and turbo decoding, the convergence behavior by using the informed asynchronous scheduling is first demonstrated to be similar to the standard sequential scheduling. As the extrinsic log-likelihood ratio (LLR) calculation at both the MIMO demapper and turbo decoder costs high complexity, an informed message update (IMU) rule is further proposed to select only a subset of extrinsic LLRs for updates within each iteration. By avoiding the re-calculations for the extrinsic LLRs with small changes between successive iterations, significant complexity savings are achieved with negligible error rate performance loss.
Dimethyl Disulfide Produced by the Naturally Associated Bacterium Bacillus sp B55 Promotes Nicotiana attenuata Growth by Enhancing Sulfur Nutrition[W]

This work examines the mechanism of N. attenuata growth promotion by Bacillus sp B55. It finds that volatile DMDS production by the bacterium likely enhances the availability of reduced S, which is particularly beneficial for wild-type plants growing in S-deficient soils and for 35S-etr1 plants due to impaired S uptake/assimilation/metabolism. Bacillus sp B55, a bacterium naturally associated with Nicotiana attenuata roots, promotes growth and survival of wild-type and, particularly, ethylene (ET)–insensitive 35S-ethylene response1 (etr1) N. attenuata plants, which heterologously express the mutant Arabidopsis thaliana receptor ETR1-1. We found that the volatile organic compound (VOC) blend emitted by B55 promotes seedling growth, which is dominated by the S-containing compound dimethyl disulfide (DMDS). DMDS was depleted from the headspace during cocultivation with seedlings in bipartite Petri dishes, and 35S was assimilated from the bacterial VOC bouquet and incorporated into plant proteins. In wild-type and 35S-etr1 seedlings grown under different sulfate (SO4−2) supply conditions, exposure to synthetic DMDS led to genotype-dependent plant growth promotion effects. For the wild type, only S-starved seedlings benefited from DMDS exposure. By contrast, growth of 35S-etr1 seedlings, which we demonstrate to have an unregulated S metabolism, increased at all SO4−2 supply rates. Exposure to B55 VOCs and DMDS rescued many of the growth phenotypes exhibited by ET-insensitive plants, including the lack of root hairs, poor lateral root growth, and low chlorophyll content. DMDS supplementation significantly reduced the expression of S assimilation genes, as well as Met biosynthesis and recycling. We conclude that DMDS by B55 production is a plant growth promotion mechanism that likely enhances the availability of reduced S, which is particularly beneficial for wild-type plants growing in S-deficient soils and for 35S-etr1 plants due to their impaired S uptake/assimilation/metabolism.
Analytical and clinical evaluation of the Bayer ADVIA Centaur automated B-type natriuretic peptide assay in patients with heart failure: a multisite study.

BACKGROUND B-Type natriuretic peptide (BNP) is released from the left ventricle of the heart into the circulation in response to ventricular stretching and volume overload. Increased BNP concentrations are associated with heart failure (HF). METHODS We evaluated the analytical and clinical performance of the Bayer ADVIA Centaur BNP assay. Studies included precision, analytical correlation (against the Shionogi ShionoRIA and Biosite Triage BNP assays), BNP results for blood collected in plastic tubes containing EDTA vs other collection tubes, high-dose hook effect, detection limits, and interferences. The clinical performance was tested on 2243 blood samples collected from 983 apparently healthy individuals, 538 patients with chronic disease but without HF (renal insufficiency, chronic obstructive pulmonary disease, diabetes, and hypertension), and 722 patients with HF (New York Heart Association classes I-IV). RESULTS The ADVIA Centaur assay had total imprecision (CV) of 3.4%, 2.9%, and 2.4% at BNP concentrations of 48, 461, and 1768 ng/L, respectively. The Passing-Bablok correlations to the ShionoRIA and Triage were as follows: ADVIA Centaur = 1.11(ShionoRIA) - 1.19 ng/L (r = 0.98); ADVIA Centaur = 0.78(Triage) + 5.89 ng/L (r = 0.92), respectively. Of the different blood collection tubes, only EDTA plastic tubes (with and without the barrier gel) were acceptable. The lower detection limit was 0.5 ng/L, and there were no interferences from common analytes, other neuropeptides, or unusual antibodies. BNP exhibited different reference intervals according to age and gender. BNP concentrations increased progressively as the severity of HF increased. CONCLUSIONS The ADVIA Centaur is the first commercially available BNP assay for use on an automated immunochemistry platform. This assay has good analytical and clinical performance characteristics for diagnosing HF.