Miracle-dz/UniFAR-FTUs huggingface dataset:
Improvement of Secondary Metabolites from Phyllanthus odontadenius against Malaria by Mutagenesis

Aims: Majority of deaths in children aged under 5 years are due to Plasmodium falciparum malaria. Malaria deaths in children decreased but malaria remains a major killer of children, taking the life of a child every 2 minutes. This study aims to investigate the increasing of the in vitro antiplasmodial activities by mutagenesis techniques using gamma-rays (Cs-137) or sodium azide (NaN 3 ) as mutagens. It will allow the importance of mutagenesis use as tools for improvement of secondary metabolites against malaria parasites using chemical or physical mutagens. Study Design: Laboratory experiment tests : identification of plant material, immersion of seeds in SA (sodium azide) solutions or irradiation by Gamma-rays (Cs-137) of P. odontadenius seeds for improvement of secondary metabolites against malaria parasites, in vitro culture of seeds followed by the in situ culturing of plantlets for obtaining material of study, phytochemical screening of Phyllanthus odontadenius aerial parts to determine the change of compounds in comparison to controls, in vitro antiplasmodial tests for the determination of SA concentrations or those of gamma-rays doses which killing 50% of malaria parasite populations (IC 50 ). Place and Duration of Study
The effect of a heel-unloading orthosis in short-term treatment of calcaneus fractures on physical function, quality of life and return to work – study protocol for a randomized controlled trial

Background: Neither for operative nor non-operative therapy standardized guidelines for rehabilitation of calcaneus fractures are existing. While there is consensus for non or partial weight bearing, the use of supporting devices such as speci�c foot ankle orthosis is still a matter of debate. Recently, a heel-unloading orthosis (‘Settner shoe’) was introduced for aftercare of these fractures, allowing walking by shifting the load to the middle- and forefoot. This orthosis enables early mobilization of patients suffering from both one-and two-sided fractures. The ‘Settner shoe’ can be applied in non-operative therapy and following operations. Speci�cally in calcaneus fractures, early regain of physical activity has been highlighted as one of the key factors for quality of life and the ability to return to work. Thus, we hypothesize that mobilization with the ‘Settner shoe’ results in higher physical activity within the �rst 3 months, which is the primary outcome criterion. Methods: This is going to be analyzed by a randomized controlled study comparing treatment with and without this speci�c orthosis. The secondary outcome measures are the time point of return to work in calcaneus fracture patients aged between 18 and 60 years. Furthermore, the American Orthopaedic Foot and Ankle Society's (AOFAS) ankle-hindfoot score, a 3-dimensional gait analysis, and the EQ-5D-3L questionnaire for quality of life are assessed. Discussion: It is the �rst trail applying a standardized rehabilitation protocol in patients suffering from calcaneus fractures aiming to improve the non-operative part of treatment by the use of an orthosis.
Acral myxoinflammatory fibroblastic sarcomas: are they all low‐grade neoplasms?

Acral myxoinflammatory fibroblastic sarcoma (AMIFS) is a low‐grade sarcoma that presents mostly in distal extremities of middle‐aged patients. The clinicopathologic features, immunohistochemical profile and follow‐up data of five cases (three men and two women; age 39–65 years) are presented. The tumors presented as a slow‐growing, poorly circumscribed, subcutaneous masses in the hands (three), foot (one) and calf (one), with dermal involvement in two cases. They had myxoid and hyaline stroma with dense acute and chronic inflammation. Spindle cells, large bizarre ganglion‐like cells and multivacuolated cells were seen. Variable reactivity in lesional cells were noted for vimentin, Alpha‐1‐antitrypsin (A1AT), factor XIIIa, CD68, CD95, CD117, Alpha‐1‐antichymotrypsin (A1ACT), CD34, AE1/3, S‐100 protein, EBER, CD63 and CD15. MIB‐1 showed 5–30% nuclear labeling. They were negative for cytokeratin AE1/3, smooth muscle actin, CD30, ALK‐1, EMA, desmin, CMV, HMB‐45 and Melan‐A. Follow up ranged from 2 weeks to 95 months (mean 54). One patient was lost to follow up; three underwent excision and one patient had below the knee amputation. Two patients developed metastases (one died of disease), and two patients are alive without evidence of disease. AMIFS are rare tumors that may involve joints and tendons leading to clinical diagnosis of ganglion cyst or tenosynovitis.
Real-Time Dynamic Data Driven Deformable Registration for Image-Guided Neurosurgery: Computational Aspects

Current neurosurgical procedures utilize medical images of various modalities to enable the precise location of tumors and critical brain structures to plan accurate brain tumor resection. The difficulty of using preoperative images during the surgery is caused by the intra-operative deformation of the brain tissue (brain shift), which introduces discrepancies concerning the preoperative configuration. Intra-operative imaging allows tracking such deformations but cannot fully substitute for the quality of the pre-operative data. Dynamic Data Driven Deformable Non-Rigid Registration (D4NRR) is a complex and time-consuming image processing operation that allows the dynamic adjustment of the pre-operative image data to account for intra-operative brain shift during the surgery. This paper summarizes the computational aspects of a specific adaptive numerical approximation method and its variations for registering brain MRIs. It outlines its evolution over the last 15 years and identifies new directions for the computational aspects of the technique.
Studies of HAMR Recording by Hybrid Monte Carlo Micromagnetics

The heat-assisted magnetic recording (HAMR) has been studied extensively for its application in extremely high-density hard disk drives. In this paper, we utilize the hybrid Monte Carlo micromagnetics to investigate the HAMR write process and the recording performances by evaluating the signal-to-noise ratio (SNR). The simulation results show that, recording on granular FePt-C media with a grain size (D) ~4 nm, the medium SNR drops to 8.36 dB with areal density reaching to ~4 Tbit/in<sup>2</sup>. Furthermore, the effects of grain size distribution and Curie temperature (<inline-formula> <tex-math notation="LaTeX">$T\text{c}$ </tex-math></inline-formula>) distribution on HAMR recording are introduced in our simulation considering the sputter conditions in experiments. We build up HAMR recording models by varying grain size distribution and Tc distribution and find out that the effect of the Tc distribution is much stronger than the grain size distribution. With <inline-formula> <tex-math notation="LaTeX">$\sigma T\text{c}/T\text{c}\,\,=0.037$ </tex-math></inline-formula> (<inline-formula> <tex-math notation="LaTeX">$\sigma \text{D}$ </tex-math></inline-formula>/D = 0.09), the SNR decreases from 15.14 to 12.72 dB while the SNR decreases to 15.01 dB with <inline-formula> <tex-math notation="LaTeX">$\sigma \text{D}$ </tex-math></inline-formula>/D rising from 0.09 to 0.15 (<inline-formula> <tex-math notation="LaTeX">$\sigma T\text{c}/T\text{c}\,\,=0$ </tex-math></inline-formula>).
Discrete Energy-Conservation Properties in the Numerical Simulation of the Navier–Stokes Equations

Nonlinear convective terms pose the most critical issues when a numerical discretization of the Navier–Stokes equations is performed, especially at high Reynolds numbers. They are indeed responsible for a nonlinear instability arising from the amplification of aliasing errors that come from the evaluation of the products of two or more variables on a finite grid. The classical remedy to this difficulty has been the construction of difference schemes able to reproduce at a discrete level some of the fundamental symmetry properties of the Navier–Stokes equations. The invariant character of quadratic quantities such as global kinetic energy in inviscid incompressible flows is a particular symmetry, whose enforcement typically guarantees a sufficient control of aliasing errors that allows the fulfillment of long-time integration. In this paper, a survey of the most successful approaches developed in this field is presented. The incompressible and compressible cases are both covered, and treated separately, and the topics of spatial and temporal energy conservation are discussed. The theory and the ideas are exposed with full details in classical simplified numerical settings, and the extensions to more complex situations are also reviewed. The effectiveness of the illustrated approaches is documented by numerical simulations of canonical flows and by industrial flow computations taken from the literature.
A new diagnostic for AMOC heat transport applied to the CESM large ensemble

Atlantic time-mean heat transport is northward at all latitudes and exhibits strong multidecadal variability between about 30N and 55N. Atlantic heat transport variability inﬂuences many aspects of the climate system, including regional surface temperatures, subpolar heat content, Arctic sea-ice concentration and tropical precipitation patterns. Atlantic heat transport and heat transport variability are commonly partitioned into two components: the heat transport by the AMOC and the heat transport by the gyres. In this paper we compare three diﬀerent methods for performing this partition
nanoradiopharmaceuticals for breast cancer imaging: development, characterization, and imaging in inducted animals

: Monoclonal antibodies as polymeric nanoparticles are quite interesting and endow this new drug category with many advantages, especially by reducing the number of adverse reactions and, in the case of radiopharmaceuticals, also reducing the amount of radiation (dose) administered to the patient. In this study, a nanoradiopharmaceutical was developed using polylactic acid (PLA)/polyvinyl alcohol (PVA)/montmorillonite (MMT)/ trastuzumab nanoparticles labeled with technetium-99m (99mTc) for breast cancer imaging. In order to confirm the nanoparticle formation, atomic force microscopy and dynamic light scattering were performed. Cytotoxicity of the nanoparticle and biodistribution with 99mTc in healthy and inducted animals were also measured. The results from atomic force microscopy showed that the nanoparticles were spherical, with a size range of ~ 200–500 nm. The dynamic light scattering analysis demonstrated that over 90% of the nanoparticles produced had a size of 287 nm with a zeta potential of - 14,6 mV. The cytotoxicity results demonstrated that the nanoparticles were capable of reaching breast cancer cells. The biodistribution data demonstrated that the PLA/PVA/MMT/trastuzumab nanoparticles labeled with 99mTc have great renal clearance and also a high uptake by the lesion, as ~ 45% of the PLA/PVA/MMT/ trastuzumab nanoparticles injected were taken up by the lesion. The data support PLA/PVA/ MMT/trastuzumab labeled with 99mTc nanoparticles as nanoradiopharmaceuticals for breast cancer imaging.
The theory of constructed emotion: an active inference account of interoception and categorization

Abstract The science of emotion has been using folk psychology categories derived from philosophy to search for the brain basis of emotion. The last two decades of neuroscience research have brought us to the brink of a paradigm shift in understanding the workings of the brain, however, setting the stage to revolutionize our understanding of what emotions are and how they work. In this article, we begin with the structure and function of the brain, and from there deduce what the biological basis of emotions might be. The answer is a brain-based, computational account called the theory of constructed emotion.
Oiseaux sauvages et virus West Nile : étude éco-épidémiologique en Camargue

Le travail presente ici s'interesse au role des oiseaux sauvages dans l'epidemiologie du virus West Nile (WN) en Camargue. Des especes d'oiseaux susceptibles d'intervenir dans les differentes phases de circulation du virus (introduction, amplification, dispersion, emergence) sont identifiees en s'appuyant sur les donnees bibliographiques relatives a la maladie et sur des criteres ornithologiques. Les investigations epidemiologiques effectuees pour quelques unes de ces especes en 2004 (annee epizootique) et en 2005 (annee post-epizootique) montrent que le virus WN circule dans la population d'oiseaux de Camargue. Pour les oiseaux migrateurs arrivant d'Afrique au printemps, les dates et lieux de ces contacts restent inconnus. Concernant les oiseaux sedentaires, deux isolats d'une meme souche virale ont ete obtenus en 2004, reciproquement a partir du cerveau d'une Pie bavarde Pica pica et d'un Moineau domestique Passer domesticus, et totalement sequences. L'etude phylogenetique de cette souche montre qu'elle appartient au meme cluster que celles precedemment isolees en Europe mediterraneenne. Les resultats serologiques et virologiques chez ces deux especes d'oiseaux, souvent observees a proximite des ecuries, en font des candidates a l'amplification et l'emergence du virus WN chez les chevaux de Camargue. La mise en evidence, en 2005, d'ARN viral dans les fientes d'une Pie bavarde conforte cette hypothese. Les recherches doivent se poursuivre pour evaluer la part respective des differents oiseaux de Camargue dans la circulation du virus WN en utilisant d'autres approches, comme par exemple l'analyse des repas de sang des moustiques vecteurs, recemment identifies.
Characterization of sympatric Platanthera bifolia and Platanthera chlorantha (Orchidaceae) populations with intermediate plants

Platanthera bifolia and P. chlorantha are terrestrial and rewarding orchids with a wide Eurasian distribution. Although genetically closely related, they exhibit significant morphological, phenological and ecological differences that maintain reproductive isolation between the species. However, where both species co-occur, individuals with intermediate phenotypic traits, often considered as hybrids, are frequently observed. Here, we combined neutral genetic markers (AFLPs), morphometrics and floral scent analysis (GC-MS) to investigate two mixed Platanthera populations where morphologically intermediate plants were found. Self-pollination experiments revealed a low level of autogamy and artificial crossings combined with assessments of fruit set and seed viability, showed compatibility between the two species. The results of the genetic analyses showed that morphologically intermediate plants had similar genetic patterns as the P. bifolia group. These results are corroborated also by floral scent analyses, which confirmed a strong similarity in floral scent composition between intermediate morphotypes and P. bifolia. Therefore, this study provided a much more detailed picture of the genetic structure of a sympatric zone between two closely allied species and supports the hypothesis that intermediate morphotypes in sympatry could reflect an adaptive evolution in response to local pollinator-mediated selection.
Cryo-EM structure of the PYD filament of AIM2

Absent in melanoma 2 (AIM2) is an essential cytosolic double-stranded DNA receptor that assembles with the adaptor, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and caspase-1 to form the AIM2 inflammasome, which leads to proteolytic maturation of cytokines and pyroptotic cell death. AIM2 contains an N-terminal Pyrin domain (PYD) that interacts with ASC through PYD/PYD interactions and nucleates ASCPYD filament formation. To elucidate the molecular basis of AIM2-induced ASCPYD polymerization, we generated AIM2PYD filaments fused to green fluorescent protein (GFP) and determined its cryo-electron microscopic (cryo-EM) structure. The map showed distinct definition of helices, allowing fitting of the crystal structure. Surprisingly, the GFP-AIM2PYD filament is a 1-start helix with helical parameters distinct from those of the 3-start ASCPYD filament. However, despite the apparent symmetry difference, helical net and detailed interface analyses reveal minimal changes in subunit packing. GFP-AIM2PYD nucleated ASCPYD filament formation in comparable efficiency as untagged AIM2PYD, suggesting assembly plasticity in both AIM2PYD and ASCPYD. The DNA-binding domain of AIM2 is able to form AIM2/DNA filaments, within which the AIM2PYD is brought into proximity to template ASCPYD filament assembly. Because ASC is able to interact with many PYD-containing receptors for the formation of inflammasomes, the observed structural plasticity may be critically important for this versatility in the PYD/PYD interactions.
Design and development of a self calibrated optical chip interferometer for high precision on-line surface measurement

Surface characterization plays an important role in many manufacturing processes. In this paper we propose the development of a hybrid optical chip interferometer device which will allow online surface measurement at high precision with improved autonomy. The research methodology involves the integration of individual optoelectronic components onto a silicon daughterboard which is then incorporated on a silica motherboard to produce the final hybrid structure. The fundamental principle of operation of the device is based on wavelength scanning interferometry and optical phase measurement techniques. The integrated optics chip device combined with an optical probe will be compact and robust and may be used for high precision surface measurement and absolute distance measurement.
Vesicular Stomatitis Virus–Based Vaccines against Lassa and Ebola Viruses

We demonstrated that previous vaccination with a vesicular stomatitis virus (VSV)–based Lassa virus vaccine does not alter protective efficacy of subsequent vaccination with a VSV-based Ebola virus vaccine. These findings demonstrate the utility of VSV-based vaccines against divergent viral pathogens, even when preexisting immunity to the vaccine vector is present.
THE EFFECT OF CORPORATE REPUTATION AND WOMAN DIRECTOR ON CORPORATE FINANCIAL PERFORMANCE AS MODERATED NARCISSISM EXECUTIVE.

This study aims to determine the effect of corporate reputation and woman director on corporate financial performance moderated by narcissism executive. The sample of this study was 114 companies listed on the Indonesia Stock Exchange and has an excellent value from IMAC. Research data uses annual reports and CII during the 2015-2017 period obtained from Indonesian Capital Exchange (IDX) and Indonesian Corporate Image Award (IMAC). Data analysis uses analysis of Moderated Regression Analysis (MRA). The results show that (1) corporate reputation has a positive effect on corporate financial performance, (2) woman director has a negative effect on the corporate financial performance, (3) narcissism executive positive effect on corporate financial performance, (4) narcissism executive can moderate the effects of corporate reputation on corporate financial performance, (5) narcissism executives can moderate the effects of woman director on corporate financial performance. The implications of the research are that this research is expected to give benefits to companies and investors, especially on the The results of his research show that there is a Methodology:-This study uses a quantitative research approach that aims to determine the extent of the influence of corporate reputation and woman director on corporate financial performance moderated by narcissism executive. The population in this study are all companies listed on the Indonesia Stock Exchange during 2015-2017. The sample selection technique used is non-probability with sampling based on criteria (purposive sampling), that is (1) companies listed on the Indonesia Stock Exchange (IDX) and issuing annual reports during 2015-2017, (2) companies that have excellent results on the Indonesian Corporate Image Award, and (3) companies that have complete data needed in this study. The analysis technique uses multiple linear regression analysis expressed in a relationship between corporate reputation and woman director on corporate financial performance moderated by narcissism executive.
evaluation of various equations for estimating renal function in elderly Chinese patients with type 2 diabetes mellitus

Background: The clinical assessment of kidney function based on the estimated glomerular filtration rate (GFR) in older patients remains controversial. This study evaluated the concordance and feasibility of using various creatinine-based equations for estimating GFR in elderly Chinese patients with type 2 diabetes mellitus (T2DM). Methods: A cross-sectional analytical study was conducted in 21,723 older diabetic patients ( $ 60 years) based on electronic health records (EHR) for Minhang District, Shanghai, China. The concordance of chronic kidney disease (CKD) classification among different creatinine-based equations was assessed based on Kappa values, intraclass correlation coefficient (ICC) statistics, and the eGFR agreement between the equations was tested using Bland–Altman plots. The GFR was estimated using the Cockcroft–Gault (CG), Berlin Initiative Study 1 (BIS1), simplified Modification of Diet in Renal Disease (MDRD), MDRD modified for Chinese populations (mMDRD), chronic kidney disease epidemiology collaboration (CKD-EPI), CKD-EPI in Asians (CKD-EPI-Asia), and Ruijin equations. Results: Overall, the proportion of CKD stages 3–5 (eGFR , 60 mL/min/1.73 m 2 ) was calculated as 28.9%, 39.1%, 11.8%, 8.4%, 14.3%, 11.5%, and 12.7% by the eGFR CG , eGFR BIS1 , eGFR MDRD , eGFR mMDRD , eGFR CKD-EPI , eGFR CKD-EPI-Asia , and eGFR Ruijin equations, respectively. The concordance of albuminuria and decreased eGFR based on the different equations was poor by both the Kappa ( , 0.2) and ICC ( , 0.4) statistics. The CKD-EPI-Asia equation resulted in excellent concordance with the CKD-EPI (ICC = 0.931), MDRD (ICC = 0.963), mMDRD (ICC = 0.892), and Ruijin (ICC = 0.956) equations for the classification of CKD stages, whereas the BIS1 equation exhibited good concordance with the CG equation (ICC = 0.809). In addition, significant differences were observed for CKD stage 1 among all these equations. Conclusion: Accurate GFR values are difficult to estimate using creatinine-based equations in older diabetic patients. Kidney function is complex, and the staff need to be aware of the individualized consideration of other risk factors or markers of reduced renal function in clinical practice.
: Current

Service quality (SQ) plays an important role as a driver of customer satisfaction (CS). This paper attempts to assess the effects of SQ on CS in the Ethio-Djibouti railway transport service. A questionnaire was constructed with 42 SQ items covering 8 SQ dimensions using the ServQual model with additional dimensions added by the researchers. A total of 251 respondents were taken using the convenience sampling technique to collect the required data. Minitab software has been used to perform the data analysis and interpretation. As the finding shows, there is a gap between customers’ perceptions and expectations of SQ in the transport service. As a result, reliability, assurance, service delivery, empathy and tangibility contributed a higher value to CS, and comfort and social responsibility a higher value contribution to CS. Therefore, the provider has to focus on improving the SQ to bring CS