Miracle-dz/UniFAR-FTUs huggingface dataset:
Colorectal cancer survivors undergoing genetic testing for hereditary non‐polyposis colorectal cancer: motivational factors and psychosocial functioning

Hereditary non‐polyposis colorectal cancer (HNPCC) represents about 1–3% of all cases of colorectal cancer (CRC). The objectives of the study were to examine motivational factors, expectations and psychosocial functioning in a sample of CRC survivors undergoing genetic testing for HNPCC. A cross‐sectional survey of 314 colorectal cancer patients recruited through a population‐based colon cancer family registry was conducted. Motivations for genetic testing for hereditary cancer were similar to those of clinic‐based samples of CRC patients and included learning of the increased risk to offspring and finding out if additional screening was needed. While age at diagnosis and sex were associated with psychological functioning, significant predictors of post‐counseling distress were perceived lower satisfaction with social support, an escape‐avoidant coping style and the anticipation of becoming depressed if a mutation was present. Most cancer survivors anticipated disclosing test results to relatives and physicians. Cancer survivors reported several motivations for genetic testing for HNPCC that varied by sex. A subgroup of survivors with lower satisfaction with social support and an escape‐avoidant coping style were worried about the potential impact of genetic test results and demonstrated more distress following counseling. Findings have implications for future research and potential support needs during the genetic counseling and testing process.
Identification of the merR gene of R100 by using mer-lac gene and operon fusions

Transcriptional (operon) and translational (gene) fusions between the R100 merR gene and lacZ were constructed in vitro in a pBR322 plasmid carrying the mer genes derived from plasmid R100. The translational fusions were oriented in the opposite direction to and divergently from the merTCAD genes. This shows that the reading frame previously thought to be merR was incorrect. Expression of the gene fusion was repressed in trans by a compatible plasmid carrying the R100 merR+ gene, as was a similarly oriented transcriptional fusion. In contrast, expression of beta-galactosidase by the lac fragment located at the same site but in the opposite orientation was at a lower level and was not repressed by merR+.
GECC: Gene Expression Based Ensemble Classification of Colon Samples

Gene expression deviates from its normal composition in case a patient has cancer. This variation can be used as an effective tool to find cancer. In this study, we propose a novel gene expressions based colon classification scheme (GECC) that exploits the variations in gene expressions for classifying colon gene samples into normal and malignant classes. Novelty of GECC is in two complementary ways. First, to cater overwhelmingly larger size of gene based data sets, various feature extraction strategies, like, chi-square, F-Score, principal component analysis (PCA) and minimum redundancy and maximum relevancy (mRMR) have been employed, which select discriminative genes amongst a set of genes. Second, a majority voting based ensemble of support vector machine (SVM) has been proposed to classify the given gene based samples. Previously, individual SVM models have been used for colon classification, however, their performance is limited. In this research study, we propose an SVM-ensemble based new approach for gene based classification of colon, wherein the individual SVM models are constructed through the learning of different SVM kernels, like, linear, polynomial, radial basis function (RBF), and sigmoid. The predicted results of individual models are combined through majority voting. In this way, the combined decision space becomes more discriminative. The proposed technique has been tested on four colon, and several other binary-class gene expression data sets, and improved performance has been achieved compared to previously reported gene based colon cancer detection techniques. The computational time required for the training and testing of 208 × 5,851 data set has been 591.01 and 0.019 s, respectively.
Determining the protein repertoire of Cryptosporidium parvum sporozoites

The genome of the intracellular parasite Cryptosporidium parvum has recently been sequenced, but protein expression data for the invasive stages of this important zoonotic gastrointestinal pathogen are limited. In this paper a comprehensive analysis of the expressed protein repertoire of an excysted oocyst/sporozoite preparation of C. parvum is presented. Three independent proteome platforms were employed which yielded more than 4800 individual protein identifications representing 1237 nonredundant proteins, corresponding to ∼30% of the predicted proteome. Peptide data were mapped to the corresponding locations on the C. parvum genome and a publicly accessible interface for proteome data was developed for data‐mining and visualisation at CryptoDB (http://cryptodb.org). These data provide a timely and valuable resource for improved annotation of the genome, verification of predicted hypothetical proteins and identification of proteins not predicted by current gene models. The data indicated the expression of proteins likely to be important to the invasion and intracellular establishment of the parasite, including surface proteins, constituents of the remnant mitochondrion and apical organelles. Comparison of the expressed proteome with existing transcriptional data indicated only a weak correlation. For approximately half the proteome there was limited functional and structural information, highlighting the limitations in the current understanding of Cryptosporidium biology.
Synchronicity, instant messaging, and performance among financial traders

Successful animal systems often manage risk through synchronous behavior that spontaneously arises without leadership. In critical human systems facing risk, such as financial markets or military operations, our understanding of the benefits associated with synchronicity is nascent but promising. Building on previous work illuminating commonalities between ecological and human systems, we compare the activity patterns of individual financial traders with the simultaneous activity of other traders—an individual and spontaneous characteristic we call synchronous trading. Additionally, we examine the association of synchronous trading with individual performance and communication patterns. Analyzing empirical data on day traders’ second-to-second trading and instant messaging, we find that the higher the traders’ synchronous trading is, the less likely they are to lose money at the end of the day. We also find that the daily instant messaging patterns of traders are closely associated with their level of synchronous trading. This result suggests that synchronicity and vanguard technology may help traders cope with risky decisions in complex systems and may furnish unique prospects for achieving collective and individual goals.
Transformational and Coercive Strategies for Planned Organizational Change: Beyond the O.D. Model

This paper challenges the universality of O.D. theory, arguing that it presents an incomplete model of organizational change. Two contrasting 'theories' of organization al change are compared and evaluated (the incremental and transformational theses) and also two contrasting methods of change: participation and coercion. All four approaches are seen as legitimate components of a differentiated contingency model of change. The model has implications for the choice of strategies for managing organizational change in differing circumstances and for the training of change agents.
Families and fortunes

Since the managerial thesis (notably Berle and Means’ classic study), the role of the family in capitalist enterprise and organization has often been viewed as an anachronism, the remnant of an earlier era. This article uses qualitative interviews with wealthy Australians to argue that family relationships are an enduring influence in relation to accumulation, succession and inheritance. There are two reasons. First, the decline of family control in big business is not just a historical event, but also an ongoing event that informs the passage of most entrepreneurial businesses as they grow in scale and complexity; hence the enduring influence of nepotism in large companies such as News Corporation. Second, a variety of considerations - including dynastic ambitions, tax minimization and trust - encourage family members to cooperate in the management of inheritance through family business institutions, from family holding companies to family offices. These family business institutions possibly reflect the rise of ‘network forms of organization’ grounded in personal trust, at the expense of large companies.
A cross-layer framework for spectrum management in mobile ad hoc networks

In this paper we develop a new cross-layer framework for adaptive spectrum management in practical mobile ad hoc networks. We first propose a two-step spectrum sensing algorithm with reduced hardware complexity which improves energy efficiency without requiring knowledge of the spectrum sparsity. We then incorporate our spectrum sensing algorithm into our proposed distributed spectrum access protocol, based on local orthogonality and well suited for clustered ad hoc networks. We show via simulations that our proposed cross-layer scheme achieves near-optimal spectrum utilization under various operating scenarios, and we provide design guidelines for all system parameters. Simulations also verify the robustness of our scheme, showing that its performance is only marginally affected by errors in the spectrum sensing phase.
Sjuksköterskestudenters attityder till att ta emot vård av en manlig eller kvinnlig sjuksköterska

Research has indicated that patients prefer to be cared for by a nurse of the same sex, particularly in intimate care. This could mean that patients are often cared for by a nurse who causes them embarrassment. In order to better understand patients' preference for female or male nurses it may be useful for student nurses to be aware of their personal attitude regarding being cared for by a man or a woman. The aim of this study was to illuminate if student nurses' sexual orientation influenced their personal preference for male or female nurses. Purposive sampling was used to find out if their attitude regarding preference had to do with age or other experiences. An investigation pertaining to this and answered by 269 students, has been carried out among student nurses. The result shows that women opted for a nurse of the same sex, while men did not find the nurse's sex important. This could mean that patients' preference for a nurse of the same sex depends on if they personally feel embarrassed about being cared for by a nurse of the opposite sex, or if indeed they had taken for granted that the nurse would be a woman.
Parallel approximation algorithms for facility-location problems

This paper presents the design and analysis of parallel approximation algorithms for facility-location problems, including NC and RNC algorithms for (metric) facility location, k-center, k-median, and k-means. These problems have received considerable attention during the past decades from the approximation algorithms community, which primarily concentrates on improving the approximation guarantees. In this paper, we ask: Is it possible to parallelize some of the beautiful results from the sequential setting? Our starting point is a small, but diverse, subset of results in approximation algorithms for facility-location problems, with a primary goal of developing techniques for devising their efficient parallel counterparts. We focus on giving algorithms with low depth, near work efficiency (compared to the sequential versions), and low cache complexity.
Butyrophilin 3A/CD277–Dependent Activation of Human γδ T Cells: Accessory Cell Capacity of Distinct Leukocyte Populations

Human Vγ9Vδ2 T cells recognize in a butyrophilin 3A/CD277–dependent way microbial (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) or endogenous pyrophosphates (isopentenyl pyrophosphate [IPP]). Nitrogen-bisphosphonates such as zoledronic acid (ZOL) trigger selective γδ T cell activation because they stimulate IPP production in monocytes by inhibiting the mevalonate pathway downstream of IPP synthesis. We performed a comparative analysis of the capacity of purified monocytes, neutrophils, and CD4 T cells to serve as accessory cells for Vγ9Vδ2 T cell activation in response to three selective but mechanistically distinct stimuli (ZOL, HMBPP, agonistic anti-CD277 mAb). Only monocytes supported γδ T cell expansion in response to all three stimuli, whereas both neutrophils and CD4 T cells presented HMBPP but failed to induce γδ T cell expansion in the presence of ZOL or anti-CD277 mAb. Preincubation of accessory cells with the respective stimuli revealed potent γδ T cell–stimulating activity of ZOL- or anti-CD277 mAb-pretreated monocytes, but not neutrophils. In comparison with monocytes, ZOL-pretreated neutrophils produced little, if any, IPP and expressed much lower levels of farnesyl pyrophosphate synthase. Exogenous IL-18 enhanced the γδ T cell expansion with all three stimuli, remarkably also in response to CD4 T cells and neutrophils preincubated with anti-CD277 mAb or HMBPP. Our study uncovers unexpected differences between monocytes and neutrophils in their accessory function for human γδ T cells and underscores the important role of IL-18 in driving γδ T cell expansion. These results may have implications for the design of γδ T cell–based immunotherapeutic strategies.
A study of anterior femoral curvature in man

A study of anterior femoral curvature was carried out on a total of 874 White, Negro, Eskimo, and American Indian femora. Variations in race, sex, and side, as well as ontogenetic changes, have been investigated. The results indicate that distinct differences in the amount and location of femoral curvature exist. Sex and side differences were generally found to be small, race differences however, in both sexes, are striking. When used with other established criteria, these data on femora will be of value in identifying skeletons of certain racial groups.
TRex - The Refactoring and Metrics Tool for TTCN-3 Test Specifications

Comprehensive testing of modern communication systems often requires large and complex test suites which then have to be maintained throughout the system life-cycle. Industrial experience, with those written in the standardised testing and test control notation (TTCN-3), has shown that this maintenance is a non-trivial task and its burden could be reduced if appropriate tool support existed. To this aim, Motorola has collaborated with the University of Gottingen to develop TRex, a TTCN-3 development environment published under the Eclipse Public License, which notably provides suitable metrics and refactorings to enable the assessment and automatic restructuring of test suites. In this paper we present the TRex tool, which will make it far easier to construct and maintain TTCN-3 tests that are concise and optimally balanced with respect to readability, usability, and maintainability
An effect size distribution analysis of heart rate variability studies: Recommendations for reporting the magnitude of group differences

The calculation of heart rate variability (HRV) is a popular tool used to investigate differences in cardiac autonomic control between population samples. When interpreting effect sizes to quantify the magnitude of group differences, researchers typically use Cohen's guidelines of small (0.2), medium (0.5), and large (0.8) effects. However, these guidelines were only proposed for use when the effect size distribution (ESD) was unknown. Despite the availability of effect sizes from hundreds of HRV studies, researchers still largely rely on Cohen's guidelines to interpret effect sizes. This article describes an ESD analysis of 297 HRV effect sizes from case-control studies, revealing that the 25th, 50th, and 75th effect size percentiles correspond with effect sizes of 0.25, 0.5, and 0.84, respectively. The ESD for separate clinical groups are also presented. The data suggests that Cohen's guidelines underestimate the magnitude of small and large effect sizes for the body of HRV case-control research. Therefore, to better reflect observed HRV effect sizes, the data suggest that effect sizes of 0.25, 0.5, and 0.85 should be interpreted as small, medium, and large effects. Researchers are encouraged to use the ESD dataset or their own collected datasets in tandem with the provided analysis script to perform bespoke ESD analyses relevant to their specific research area.
Impact of endoscopic biopsy surveillance of Barrett’s oesophagus on pathological stage and clinical outcome of Barrett’s carcinoma

Background—The efficacy of endoscopic biopsy surveillance of Barrett’s oesophagus in reducing mortality from oesophageal cancer has not been confirmed. Aims—To investigate the impact of endoscopic biopsy surveillance on pathological stage and clinical outcome of Barrett’s carcinoma. Methods—A clinicopathological comparison was made between patients who initially presented with oesophageal adenocarcinoma (n=54), and those in whom the cancer had been detected during surveillance of Barrett’s oesophagus (n=16). Results—The surveyed patients were known to have Barrett’s oesophagus for a median period of 42 months (range 6–144 months). Prior to the detection of adenocarcinoma or high grade dysplasia, 13 of 16 patients (81%) were previously found to have low grade dysplasia. Surgical pathology showed that surveyed patients had significantly earlier stages than non-surveyed patients (p=0.0001). Only one surveyed patient (6%) versus 34 non-surveyed patients (63%) had nodal involvement (p=0.0001). Two year survival was 85.9% for surveyed patients and 43.3% for non-surveyed patients (p=0.0029). Conclusions—The temporal course of histological progression in our surveyed patients supports the theory that adenocarcinoma in Barrett’s oesophagus develops through stages of increasing severity of dysplasia. Endoscopic biopsy surveillance of Barrett’s oesophagus permits detection of malignancy at an early and curable stage, thereby potentially reducing mortality from oesophageal adenocarcinoma.
Loss of expression of the metastasis suppressor gene KiSS1 during melanoma progression and its association with LOH of chromosome 6q16.3-q23.

KiSS1 is a putative melanoma metastasis suppressor gene, the expression of which may be regulated by another gene(s) mapping to chromosome 6q16.3-q23. To additionally elucidate the role of KiSS1 in the progression of human melanoma in vivo, we examined KiSS1 mRNA expression in 51 melanocytic tumors with various stages of progression by in situ hybridization. We also examined a correlation between loss of KiSS1 mRNA expression and loss of heterozygosity (LOH) of 6q16.3-q23 in 27 melanoma metastases. All of the four nevocellular nevi and eight primary melanomas <4 mm in thickness showed KiSS1 mRNA expression, whereas only 50% (6 of 12) of primary melanomas >4 mm in thickness expressed KiSS1. Loss of KiSS1 mRNA was equally frequent in metastases; 44% (12 of 27) of tumors lost KiSS1 expression. LOH of 6q16.3-q23 was observed in 52% (14 of 27) of metastases. There was a strong association between LOH and loss of KiSS1 expression (P = 0.03); nine metastases with LOH of 6q16.3-q23 lost KiSS1 expression, whereas 10 tumors with no LOH showed positive KiSS1 mRNA expression. The findings in this study show, for the first time, KiSS1 down-regulation during the progression of melanoma in vivo and strongly suggest that inactivation of a tumor suppressor gene(s) mapping to 6q16.3-q23 by deletion or mutation coupled with LOH may lead to the down-regulation of KiSS1.
2D Geometry Predicts Perceived Visual Curvature in Context-Free Viewing

Planar geometry was exploited for the computation of symmetric visual curves in the image plane, with consistent variations in local parameters such as sagitta, chordlength, and the curves' height-to-width ratio, an indicator of the visual area covered by the curve, also called aspect ratio. Image representations of single curves (no local image context) were presented to human observers to measure their visual sensation of curvature magnitude elicited by a given curve. Nonlinear regression analysis was performed on both the individual and the average data using two types of model: (1) a power function where y (sensation) tends towards infinity as a function of x (stimulus input), most frequently used to model sensory scaling data for sensory continua, and (2) an “exponential rise to maximum” function, which converges towards an asymptotically stable level of y as a function of x. Both models provide satisfactory fits to subjective curvature magnitude as a function of the height-to-width ratio of single curves. The findings are consistent with an in-built sensitivity of the human visual system to local curve geometry, a potentially essential ground condition for the perception of concave and convex objects in the real world.
Priority List of Research Areas for Radiological Nuclear Threat Countermeasures

Abstract Pellmar, T. C. , Rockwell, S. and the Radiological/Nuclear Threat Countermeasures Working Group. Priority List of Research Areas for Radiological Nuclear Threat Countermeasures. Radiat. Res. 163, 115–123 (2005). To help the nation prepare for the possibility of a terrorist attack using radiological and nuclear devices, the Office of Science and Technology Policy and the Homeland Security Council established an interagency working group. The working group deliberated on the research needs for radiological/ nuclear threat countermeasures and identified and prioritized 18 areas for further attention. The highest priorities were given to research on (1) radioprotectors for use prior to exposure; (2) therapeutic agents for postexposure treatment; (3) antimicrobial therapy for infections associated with radiation exposure; (4) cytokines and growth factors; (5) mechanisms of radiation injury at the molecular, cellular, tissue and organism levels; and (6) automation of biodosimetric assays. High priority was given to (1) developing biomarkers for biodosimetry; (2) enhancing training in the radiation sciences; (3) exploring the consequences of combined injury; (4) establishing a repository of information regarding investigational countermeasures; and (5) following the health of an exposed population to better prepare for subsequent events. The research areas that the committee felt required the attention of the radiation research community are described in this report in an effort to inform this community about the needs of the nation and to encourage researchers to address these critical issues.
Reeb vector fields and open book decompositions

We determine parts of the contact homology of certain contact 3-manifolds in the framework of open book decompositions, due to Giroux. We study two cases: when the monodromy map of the compatible open book is periodic and when it is pseudo-Anosov. For an open book with periodic monodromy, we verify the Weinstein conjecture. In the case of an open book with pseudo-Anosov monodromy, suppose the boundary of a page of the open book is connected and the fractional Dehn twist coefficient $c={k\over n}$, where $n$ is the number of prongs along the boundary. If $k\geq 2$, then there is a well-defined linearized contact homology group. If $k\geq 3$, then the linearized contact homology is exponentially growing with respect to the action, and every Reeb vector field of the corresponding contact structure admits an infinite number of simple periodic orbits.