Miracle-dz/UniFAR-FTUs huggingface dataset:
A 2.4 GHz ULP Reconfigurable Asymmetric Transceiver for Single-Chip Wireless Neural Recording IC

This paper presents a 2.4 GHz ultra-low-power (ULP) reconfigurable asymmetric transceiver and demonstrates its application in wireless neural recording. Fabricated in 0.13 μm CMOS technology, the transceiver is optimized for sensor-gateway communications within a star-shaped network, and supports both the sensor and gateway operation modes. Binary phase-shift keying (BPSK) modulation with high data rate (DR) of 1 to 8 Mbps is used in the uplink from sensor to gateway, while on-off keying (OOK) modulation with low DR of 100 kbps is adopted in the downlink. A fully integrated Class-E PA with moderate output power has also been proposed and achieves power efficiency of 53%. To minimize area usage, inductor reuse is adopted between PA and LNA, and eliminates the need of lossy T/R switch in the RF signal path. When used as sensor, the transceiver with frequency locked phase-locked loop (PLL) achieves TX (BPSK) power efficiency of 28% @ 0 dBm output power, and RX (OOK) sensitivity of -80 dBm @ 100 kbps while consuming only 780 μW. When configured as gateway, the transceiver achieves sensitivity levels of -92, -84.5, and -77 dBm for 1, 5, and 8 Mbps BPSK, respectively. The transceiver is integrated with an 8-channel neural recording front-end, and neural signals from a rat are captured to verify the system functionality.
Acute and subchronic effects of agmatine on anxiety tested in the elevated plus maze in male mice

Agmatine is an endogenous polyamine, identified in mammalian brain, which meets the main criteria to be considered a neurotransmitter. Agmatine-like immunoreactivity has been described in numerous brain regions which have long been implicated in the regulation of anxiety. However, animal preclinical studies investigating effects of agmatine on anxiety are unclear. In this study, an attempt was made to clarify the actions of agmatine (7.5-60 mg/kg, ip) on anxiety tested in the elevated plus maze mice. Moreover, the possible development of tolerance to the effects of agmatine on anxiety after its subchronic administration for 7 consecutive days was also examined. A number of classical parameters were collected (open arm duration and frequency, closed arm duration and frequency and central platform duration and frequency). Different ethological measures were also obtained (rearings, headdipping and stretched attend posture). Results showed that agmatine did not produce any significant behavioural change in any of the parameters examined, suggesting that it might not be involved in the regulation of anxiety in mice.
The vector perturbation precoding for massive multiple-input multiple-output based on GMD

In this paper, we think about the massive multiple-input multiple-output system analysis of vector perturbation precoding based on channel matrix geometric mean decomposition employing the minimum mean square error criterion with instantaneous power constraints for broadcast channels. Our analysis assumes that the transmitter has the imperfect channel state information and the receivers are acquainted with a perfect channel-dependent transmit power normalization factor. We propose a descent method by iteration for searching the perturbation vector in the complex field. The performances of the devised precoding scheme with the large quantity of transmit antennas and single-antenna users are studied in respect to bit error rate analysis through simulations and the numerical results illustrate it appropriated for massive multiple-input multiple-output system both in terms of complexity and performance.
Organizational Sleepwalkers: Emotional Distress at Midlife

In this paper, attention is paid to a dysfunctional emotional behavior pattern whereby individuals experience very little (or a total absence of) pleasure. Instead, there is a feeling of emotional numbness. Although this phenomenon touches all parts of life, this paper focuses on the organizational context. For some executives, the stresses and strains of midlife (including stresses involving career issues) become the catalyst for this dysfunctional emotional behavior. Their reactions are of a quasi-alexithymic and anhedonic nature. Some of the characteristics of this dysfunctional emotional pattern are delineated in these pages. In addition, the related experience of depersonalization is highlighted. Some of the factors that contribute to these kinds of phenomena are explored. At the end of the paper, a number of recommendations for dealing with these difficulties are given.
A graph database based crowdsourcing infrastructure for modelling and searching code structure

Software reuse offers a solution to eliminate repeated work and improve efficiency and quality in the software development. In order to reuse existing software resources, software developers usually need to understand code structure of them. However, code structure is usually too complex to figure out. Therefore, it is helpful to demonstrate software developers the code structure they want to know. This paper presents a graph database based crowdsourcing infrastructure for modelling and searching code structure. In this paper, a graph based modelling paradigm of code structure is provided, which solves the problem that how code structure should be demonstrated. Software developers' search purposes are analyzed by natural language processing technique. A crowdsourcing mechanism is provided to integrate different code structure analysis algorithms for these different search purposes. Our work improves the efficiency of software reuse, and it is validated through an industrial case study.
A MOTIVAÇÃO PARA REALIZAR O AUTO-EXAME DA MAMA: UMA APLICAÇÃO DA TEORIA DA AÇÃO PLANEJADA

Um questionario, baseado em modelos de crencas sobre saude e na teoria da acao planejada, investigando o conhecimento e a pratica do auto-exame da mama foi respondido por 178 mulheres. Os re­sultados mostram um bom nivel de conhecimentos acerca dos cuidados gerais com a saude e do auto-exame da mama. As crencas acerca da pratica do auto-exame foram favoraveis, mas a preguica, as preocu­pacoes e o esquecimento foram as razoes mais frequentemente apresen­tadas como barreiras a sua pratica regular. Entre as variaveis do modelo de acao planejada duas influenciaram a intencao de realizar o auto-exa­me: as opinioes das pessoas relevantes e a experiencia anterior desta pratica, explicando 24% da variância obtida. As mulheres foram entao se­paradas em dois grupos, segundo sua pratica do auto-exame. Para o grupo que pratica o AEM a opiniao dos outros em geral, a percepcao do controle sobre o comportamento e a confianca em saber executa-lo bem, explicaram 36% da variância na intencao. Para o segundo grupo 28% da variância obtida foi explicada por um nivel mais baixo de escolaridade e ' pela opiniao das pessoas relevantes.
An Enhanced Background Estimation Algorithm for Vehicle Detection in Urban Traffic Scenes

This paper proposes a new background subtraction algorithm based on the sigma-delta filter, which is intended to be used in urban traffic scenes. The original sigma-delta algorithm is a very interesting alternative due to its high computational efficiency. However, the background model quickly degrades in complex urban scenes because it is easily “contaminated” by slow-moving or temporarily stopped vehicles. Then, subsequent foreground validation steps are needed to refine the foreground detection mask. Instead of requiring any subsequent processing steps or resorting to algorithms with higher computational cost, the proposed algorithm tries to achieve a more stable background model by introducing a confidence measurement for each pixel. This confidence measurement assists in a selective background-model updating mechanism at the pixel level. Experimental comparative tests and a quantitative performance evaluation over typical urban traffic sequences corroborate the benefits of the proposed algorithm.
Utility of Hepatic Phosphorus-31 Magnetic Resonance Spectroscopy in a Rat Model of Acute Liver Failure

The ability to document the extent of hepatic injury and predict the outcome of fulminant hepatic failure would be helpful in identifying those patients who might benefit from liver transplantation. The aim of the present study was to determine whether in vivo phosphorus-31 magnetic resonance spectroscopy (31P MRS) accurately assesses the severity of liver damage and is of prognostic value in a D-galactosamine (D-galN)-induced model of acute liver failure. Adult male Sprague-Dawley rats (n = 36) received an intraperitoneal dose of D-galN (1.0 g/kg), and MRS examinations were performed at peak (48 hours) and in subsequent experiments, just prior to peak (30 hours) hepatic injury. Rats not exposed to D-galN served as controls. The concentration of hepatic phosphorylated metabolites decreased in proportion to the severity of liver injury at 48 hours. Significant correlations were detected between hepatic adenosine triphosphate (ATP) and serum aspartate aminotransferase, bilirubin, and percentage of hepatocyte necrosis identified histologically (r = -.91, -.74, and -.92, respectively; p < .001). Prior to peak hepatic injury (30 hours), 31P MRS was able to predict with 100% accuracy those rats that would survive (ATP > 2.3 mM) and those that would not (ATP < 1.5 mM). When an intermediate cutoff value of 2.0 mM was selected, ATP levels were able to correctly predict survival and death with 80% and 60% accuracy, respectively. These findings indicate that hepatic ATP levels as measured by 31P MRS provide a noninvasive indication of the severity of liver damage and serve as a useful prognostic indicator of outcome in this model of acute liver failure.
Distributed Sparse Spatial Selection Indexes

Searching for similar objects in metric-space databases can be efficiently solved by using index data structures. A number of alternative sequential indexes have been proposed in the literature. This paper proposes the parallelization of a recent pivot-based index data structure which can efficiently accommodate on-line updates and reduces the number of object-to-object comparisons during searches. We present algorithms for index construction and query processing.
Expression of hypoxia‐associated proteins in sporadic medullary thyroid cancer is associated with desmoplastic stroma reaction and lymph node metastasis and may indicate somatic mutations in the VHL gene

Medullary thyroid carcinomas (MTCs) are mostly aggressive but slowly growing malignant tumours that metastasize early to loco‐regional lymph nodes. Desmoplastic stroma reaction is a strong risk factor associated with lymph node metastases. We evaluated immunohistochemically the expression of two hypoxia‐associated proteins, carbonic anhydrase IX (CAIX) and hypoxia‐induced factor 1α (HIF1α), and ki‐67, intercellular matrix adhesion molecule E‐cadherin and the stroma remodelling marker tenascin C in a series of 100 sporadic MTCs and corresponding lymph node metastases, if present. Moderate to strong expression of CAIX was seen in 53 cases, and of HIF1α in 51 cases, showing a strong correlation (p < 0.001; Spearman's coefficient of correlation, 0.59). Expression correlated with the degree of desmoplasia ($p_{\rm{CAIX}} = 0.001$ and $p_{{\rm{HIF1}}\alpha} = 0.001$), with tenascin C expression ($p_{\rm{CAIX}} = 0.001$, $p_{{\rm{HIF1}}\alpha} = 0.038$), with the ki‐67 proliferation index ($p_{\rm{CAIX}} = 0.001$, p$_{{\rm{HIF1}}\alpha} = 0.001$) and with the presence of lymph node metastases ($p_{\rm{CAIX}} < 0.001$ and p$_{{\rm{HIF1}}\alpha} = 0.007$). The absence of membranous E‐cadherin staining was significantly associated with the grade of desmoplasia, tenascin expression and lymph node metastases (p≤0.05) but not with ki67 proliferation index or expression of hypoxia‐associated factors. Expression of hypoxia‐associated proteins was in most cases identical between primary tumours and lymph node metastases. Two cases showed strong uniform expression of CAIX and HIF1α in the primary tumour as well as in the lymph node metastases, and sequencing revealed mutations in the coding regions of the Von‐Hippel–Lindau gene (VHL). Our findings suggest that despite of the fact that MTCs have only slowly growth, tumour hypoxia plays an important role in the development of loco‐regional metastases. Since traditional cytotoxic chemotherapy has only little effect on MTCs, targeting hypoxia‐associated and ‐regulated proteins might be of benefit for patients. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
A Cooperative Multi-Robot Approach to the Mapping and Exploration of Mars

In the AAAI 1 "Life on Mars" competition this year, we intend to employ a multi-robot team which combines traditional methods of autonomous navigation with experimental group arbitration strategies to explore and map a simulated extra-terrestrial environment. By communicating with each other to optimize the search, the robots will be able to explore the environment faster than could a single robot. Group strategies will also be used to coordinate the robot's actions to optimize the retrieval of objects in the environment.
A Network Biology Approach to Understand Combination of Drugs

Drug combination is becoming a popular strategy for combating complex traits, where combination of drugs improves therapy significantly over single agents. However, it is a challenging task to identify the optimal and effective combinations of drugs due to explosion of huge number of possible combinations among drugs. Therefore, it is necessary to understand the mechanisms underlying drug combinations. In this work, a network biology approach is presented to investi- gate the combination drugs and their target proteins in the context of protein interaction network, human pathway and functional annotations, in order to better understand the underlying rules of drug combinations. Our results indicate that the target proteins of effective combination drugs tend to be close in the protein interaction network, are more likely to be involved in the same pathways and their target proteins tend to have similar biological functions. These findings shed lights on the underlying principles of drug combinations and are helpful for identifying possible effective combinations of drugs.
Intra-aortic Balloon Pump Therapy for Acute Myocardial Infarction: A Meta-analysis.

IMPORTANCE Intra-aortic balloon pump (IABP) therapy is a widely used intervention for acute myocardial infarction with cardiogenic shock. Guidelines, which previously strongly recommended it, have recently undergone substantial change. OBJECTIVE To assess IABP efficacy in acute myocardial infarction. DATA SOURCES Human studies found in Pubmed, Embase, and Cochrane libraries through December 2014 and in reference lists of selected articles. Search strings were "myocardial infarction" or "acute coronary syndrome" and "intra-aortic balloon pump" or "counterpulsation. " STUDY SELECTION Randomized clinical trials (RCTs) and observational studies comparing use of IABP with no IABP in patients with acute myocardial infarction. DATA EXTRACTION AND SYNTHESIS Two reviewers independently extracted the data, and risk of bias in RCTs was assessed using the Cochrane risk of bias tool. We conducted separate meta-analyses of the RCTs and observational studies. Data were quantitatively synthesized using random-effects meta-analysis. MAIN OUTCOMES AND MEASURES Thirty-day mortality. RESULTS There were 12 eligible RCTs randomizing 2123 patients. In the RCTs, IABP use had no statistically significant effect on mortality (odds ratio [OR], 0.96 [95% CI, 0.74-1.24]), with no significant heterogeneity among trials (I2 = 0%; P = .52). This result was consistent when studies were stratified by the presence (OR, 0.94 [95% CI, 0.69-1.28]; P = .69, I2 = 0%) or absence (OR, 0.98 [95% CI, 0.57-1.69]; P = .95, I2 = 17%) of cardiogenic shock. There were 15 eligible observational studies totaling 15 530 patients. Their results were mutually conflicting (heterogeneity I2 = 97%; P < .001), causing wide uncertainty in the summary estimate for the association with mortality (OR, 0.96 [95% CI, 0.54-1.70]). A simple index of baseline risk marker imbalance in the observational studies appeared to explain much of the heterogeneity in the observational data (R2meta = 46.2%; P < .001). CONCLUSIONS AND RELEVANCE Use of IABP was not found to improve mortality among patients with acute myocardial infarction in the RCTs, regardless of whether patients had cardiogenic shock. The observational studies showed a variety of mutually contradictory associations between IABP therapy and mortality, much of which was explained by the differences between studies in the balance of risk factors between IABP and non-IABP groups.
An atlas of aromatase mRNA expression in the zebra finch brain

Neurol conversion of androgen to estrogen by aromatase is an important step in the development and expression of masculine behavior in mammals and birds. In contrast to the low telencephalic levels of aromatase in adult mammals and nonsongbirds, the zebra finch telencephalon possesses high arornatase activity. This study maps, by in situ hybridization, cells that express aromatase mRNA in the adult zebra finch telencephalon, diencephalon, midbrain, and pons. High aromatase mRNA expression was observed in the caudal neostriatum, limbic archistriatum, and hypothalamus. The hippocampus, parahippocampal area, and hyperstria turn accessorium contained cells expressing moderate amounts of aromatase message. Weakly labeled cells were found in the rostral neostriatum, lobus parolfactorius, and mesencephalic reticular formation. These findings are consistent with aromatase activity measurements of zebra finch tissue and document with anatomical precision both the widespread expression of aromatase mRNA in the brain and novel sites of brain aromatase. This study identifies the caudal neostriatum as a major site of telencephalic Aromatase. A previous survey (Gahr et al., 1993: J. Comp. Neurol. 327:112–122) of several avian species found that the presence of estrogen receptors in parts of the caudal neostriatum is unique to songbirds, which are the only birds to possess the elaborated telencephalic song system. Together, these findings suggest that the heightened estrogen synthesis and estrogen sensitivity of the passerine caudal neostriatum may have some functional relation with the telencephalic circuits responsible for song. © 1995 Wiley‐Liss, Inc.
Shaking video synthesis for video stabilization performance assessment

The goal of video stabilization is to remove the unwanted camera motion and obtain stable versions. Theoretically, a good stabilization algorithm should remove the unwanted motion without the loss of image qualities. However, due to the lack of ground-truth video frames, the accurate performance evaluation of different algorithms is hard. Most existing evaluation techniques usually synthesize stable videos from shaking ones, but they are not effective enough. Different from previous methods, in this paper we propose a novel method which synthesize shaking videos from stable frames. Based on the synthetic shaking videos, we perform preliminary video stabilization performance assessment on three stabilization algorithms. Our shaking video synthesis method can not only give a benchmark for full-reference video stabilization performance assessment, but also provide a basis for exploring the theoretical bound of video stabilization which may help to improve existing stabilization algorithms.
A stable hyperparameter selection for the Gaussian RBF kernel for discrimination

Kernel‐based classification methods, for example, support vector machines, map the data into a higher‐dimensional space via a kernel function. In practice, choosing the value of hyperparameter in the kernel function is crucial in order to ensure good performance. We propose a method of selecting the hyperparameter in the Gaussian radial basis function (RBF) kernel by considering the geometry of the embedded feature space. This method is independent of the choice of the discrimination algorithm and also computationally efficient. Its classification performance is competitive with existing methods including cross‐validation. Using simulated and real‐data examples, we show that the proposed method is stable with respect to sampling variability. Copyright © 2010 Wiley Periodicals, Inc. Statistical Analysis and Data Mining 3: 142‐148, 2010
2016 Ieee International Conference on Big Data (big Data) Finding Informative Comments for Video Viewing

—Video is an increasingly important method of information-sharing on the Web. Services such as YouTube, Vimeo, and Liveleak are platforms that support uploading User-Generated Content. Users tend to seek related information during or after watching an informative video by finding and reading comments on Web services. However, existing services only support sorting by recentness (newest) or rating (LIKES score), as opposed to related information. We suggest a novel method to find informative comments by considering original content and its relevance. We conducted a qualitative study of participants watching informative videos and analyzed how users interacted with the comments, the feature preferences , and the criteria for evaluation. We developed methods to measure informativeness priority, the user-provided level of information, classify intention of information posted, and cluster duplicate themes. Analysis of 1,861 TED talk videos and 380,619 comments show suggested methods can find more informative comments compared to existing methods (LIKES). I. INTRODUCTION Recently people have become more familiar with access-ing information using the Web, and information sharing using video is an important method of spreading ideas and knowledge online. For this purpose, various services, such as YouTube, Vimeo, and Liveleak, support upload-ing User-Generated Content (UGC) to the Web. People can access Massive Open Online Courses (MOOCs) using video services such as Coursera. Additionally, a popular conference video sharing service, TED, supports sharing and spreading ideas on the Web. Users tend to seek related information during or after watching an informative video. The best way to satisfy these information needs is to find and read the comments on Web services. However, existing services support only sorting by recentness (newest) or rating (LIKES score). Thus, the search for related information has limitations: • If a video receives hundreds of comments, users find it hard to refer to all comments when looking for related information. Users prefer to consider only highly ranked ones. • In the sorting method based on LIKES score, comments popular among users tend following their high ranking to be more visible than higher quality comments.
DLVHEX-SPARQL: A SPARQL Compliant Query Engine Based on DLVHEX

This paper describes the dlvhex SPARQL plugin, a query processor for the upcoming Semantic Web query language standard by W3C. We report on the implementation of this languages using dlvhex , a ﬂexible plugin system on top of the DLV solver. This work advances our earlier translation based on the semantics by Perez et al. towards an engine which is fully compliant to the ofﬁcial SPARQL speciﬁcation. As it turns out, the differences between these two deﬁni-tions of SPARQL, which might seem moderate at ﬁrst glance, need some extra machinery. We also brieﬂy report the status of implementation, and extensions currently being implemented, such as handling of aggregates, nested CONSTRUCT queries in the spirit of networked RDF graphs, or partially support of RDFS entailment. For such extensions a tight integration of SPARQL query processing and Answer-Set Programming, the underlying logic programming formalism of our engine, turns out to be particularly useful, as the resulting programs can actually involve unstratiﬁed negation.