Miracle-dz/UniFAR-FTUs huggingface dataset:
Serial Electrocardiographic Findings in a Prospective Epidemiological Study

The prevalence of classified electrocardiographic items among the adult population of Tecumseh, Michigan, during two examinations approximately 4 years apart is reported. Changes in the prevalence rates of certain items are probably due to reader differences, the effect of prior ingestion of glucose in the first series of examinations, and possibly the treatment of abnormalities detected during the first examinations.Among the cohort of 3,745 persons who had classified electrocardiograms on both examinations, the Q and QS items were relatively stable, the more marked ST and T items were less stable, and the minor ST or T classifications were extremely variable. Still, 31% of persons whose second electrocardiogram revealed codable Q or QS items for the first time had classified ST-segment or T-wave items in their previous electrocardiogram and another 9% had nonspecific QRS abnormalities, either high amplitude R waves or left axis deviation.The Minnesota code is a useful system for the classification of large numbers of electrocardiograms, but for accurate identification of new events, tracings exhibiting category I, IV, or V items must be examined serially.
Application oriented and computer science centered HPCC research

At this time, there is a perception of a backlash against the HPCC program, and even the idea of massively parallel computing itself. In preparation to deening an agenda for HPCC, this paper rst analyzes the reasons for this backlash. Although beset with unrealistic expectations, parallel processing will be a beneecial technology with a broad impact , beyond applications in science. However, this will require signiicant advances and work in computer science in addition to parallel hardware and end-applications which are emphasized currently. The paper presents a possible agenda that could lead to a successful HPCC program in the future.
Fast low‐specific absorption rate B0‐mapping along projections at high field using two‐dimensional radiofrequency pulses

At 7 Tesla (T), conventional static field (B0) projection mapping techniques, e.g., FASTMAP, FASTESTMAP, lead to elevated specific absorption rates (SAR), requiring longer total acquisition times (TA). In this work, the series of adiabatic pulses needed for slab selection in FASTMAP is replaced by a single two‐dimensional radiofrequency (2D‐RF) pulse to minimize TA while ensuring equal shimming performance.
Innovation search of new ventures in a technology cluster: the role of ties with service intermediaries

In this study, we examine the relationships between new ventures' ties with service intermediaries (i.e., technology service firms, accounting and financial service firms, law firms, and talent search firms) and their product innovation in the context of a technology cluster. Because service intermediaries sit at the intersection of many firms, organizations and industries, they maintain extensive networks in a cluster. We propose that new ventures' ties with service intermediaries enable the ventures to plug into these networks and contribute to the ventures' product innovation by broadening the scope of their external innovation search and reducing their search cost. Moreover, we argue that the positive relationships between new ventures' ties with service intermediaries and their product innovation will become stronger when search in the networks in the cluster is more important to the ventures' product innovation. Based upon a sample of new ventures in a technology cluster in China, our results support these arguments. Copyright © 2009 John Wiley & Sons, Ltd.
Selecting Effective Persuasive Strategies in Behavior Change Support Systems

The Third International Workshop on Behavior Change Support Systems provides a place to discuss recent advances in BCSS research. The selected papers show that research into behavior change support systems is expanding: not only by trying to reach more and other people, but also by expanding the contexts where BCSSs are employed. A key point for all BCSSs, for each target group and for each context, is to select the right persuasive strategies. From the proceedings we can learn that there are several ways to select and evaluate these features, but this remains an issue that deserves continuous research attention.
Infusion of Sulfosuccinimidyl-4-[N-maleimidomethyl]cyclohexane-1-carboxylate-Conjugated MOG35–55-Coupled Spleen Cells Effectively Prevents and Reverses Experimental Autoimmune Encephalomyelitis in Mice

In this study, we have evaluated our recently developed method for antigen-cell coupling using sulfosuccinimidyl-4-[N-maleimidomethyl]cyclohexane-1-carboxylate (sulfo-SMCC) heterobifunctional crosslinker in prevention and reversal of experimental autoimmune encephalomyelitis (EAE). We demonstrate that infusion of MOG35–55-coupled spleen cells (MOG-SP) significantly prevents and reverses EAE. Further studies show that the protected animals exhibit significantly delayed EAE upon EAE reinduction. Moreover, adoptive transfer of CD4+ T cells from the protected mice to naïve syngeneic mice renders the recipient mice resistant to EAE induction. Unexpectedly, CD4+ T cell proliferation is similar upon ex vivo stimulation by MOG35–55 amongst all groups. However, further analysis of those proliferating CD4+ T cells shows remarkable differences in Foxp3+ regulatory T cells (70% in MOG-SP groups versus 10–25% in control groups) and in IL-17+ cells (2-3% in MOG-SP groups versus 6–9% in control groups). In addition, we discover that MOG-SP treatment also significantly attenuates MOG35–55-responding IFN-γ-producing Th1 cells. These findings suggest that MOG-SP treatment induces EAE protective MOG35–55-specific regulatory T cells and suppresses EAE pathogenic Th17 and Th1 cells. Our study provides a novel approach for antigen-based EAE immunotherapy, which can potentially be translated into clinical application for immunotherapy of multiple sclerosis.
Error control in multi-layered stacks

The decomposition of networking functions into smaller subsets simplifies implementation and leads to open standards. Nonetheless, in applications such as mobile wireless ATM, where resources are scarce, protocol stacks must not compromise on performance. The layers of a protocol stack progressively enhance and add reliability to the supported services. Along with additional new functions, the higher layers frequently implement error control algorithms to overcome residual errors that escape the lower layers. If relatively large numbers of residual errors escape, as is likely in the mobile wireless ATM environment, then frequent retransmissions or reinitialization of the higher layer protocol entity could result in drastic loss of throughput. In this paper we examine the consequences of errors spanning two layers of a protocol stack using an explicit model to account for the interaction between two layers.
1 α , 25 ( OH ) 2 D 3 Suppresses the Migration of Ovarian Cancer SKOV-3 Cells through the Inhibition of Epithelial – Mesenchymal Transition

Ovarian cancer is the most lethal gynecological malignancy due to its high metastatic ability. Epithelial-mesenchymal transition (EMT) is essential during both follicular rupture and epithelium regeneration. However, it may also accelerate the progression of ovarian carcinomas. Experimental studies have found that 1α,25-dihydroxyvitamin-D3 [1α,25(OH)2D3] can inhibit the proliferation of ovarian cancer cells. In this study, we investigated whether 1α,25(OH)2D3 could inhibit the migration of ovarian cancer cells via regulating EMT. We established a model of transient transforming growth factor-β1(TGF-β1)-induced EMT in human ovarian adenocarcinoma cell line SKOV-3 cells. Results showed that, compared with control, 1α,25(OH)2D3 not only inhibited the migration and the invasion of SKOV-3 cells, but also promoted the acquisition of an epithelial phenotype of SKOV-3 cells treated with TGF-β1. We discovered that 1α,25(OH)2D3 increased the expression of epithelial marker E-cadherin and decreased the level of mesenchymal marker, Vimentin, which was associated with the elevated expression of VDR. Moreover, 1α,25(OH)2D3 reduced the expression level of transcription factors of EMT, such as slug, snail, and β-catenin. These results indicate that 1α,25(OH)2D3 suppresses the migration and invasion of ovarian cancer cells by inhibiting EMT, implying that 1α,25(OH)2D3 might be a potential therapeutic agent for the treatment of ovarian cancer.
The effect of coresidence with an adult child on depressive symptoms among older widowed women in South Korea: an instrumental variables estimation.

OBJECTIVES To estimate the causal effect of coresidence with an adult child on depressive symptoms among older widowed women in South Korea. METHOD Data from the first (2006) and second (2008) waves of the Korea Longitudinal Study of Ageing were used. The analysis was restricted to widowed women aged ≥65 years with at least one living child (N = 2,446). We used an instrumental variables (IVs) estimation exploiting two child characteristics as IVs (the number of sons and whether the eldest child is a daughter). Specification tests for IVs showed that these instruments predict the probability of an older widowed woman's coresidence with an adult child but do not directly affect depressive symptoms. RESULTS Our IV two-stage least-squares estimator suggested that coresidence with an adult child has a protective effect on depressive symptoms among older widowed women in South Korea. Coresidence was found to be endogenous in our statistical model of depressive symptoms. DISCUSSION The IV estimation method can be a useful approach to addressing the potential endogeneity between intergenerational coresidence and elderly health. Rapidly decreasing rates of intergenerational coresidence may raise public health concerns among older widowed women in South Korea.
Frequency Correlations of QPOs Based on a Disk Oscillation Model in Warped Disks

In previous papers, we proposed a model that high-frequency quasi-periodic oscillations (QPOs) observed in black-hole and neutron-star X-ray binaries are disk oscillations (inertial-acoustic and/or g-mode oscillations) resonantly excited on warped disks. In this paper we examine whether time variations of the QPOs and their frequenc yc orrelations observed in neutron-star X-ray binaries can be accounted for by this disk-oscillation model. By assuming that a warp has a time-dependent precession, we can well describe the observed frequency correlations among kHz QPOs and low-frequency QPOs over a wide range of frequencies.
First Results from Viper: Detection of Small-scale Anisotropy at 40 GHz

Results of a search for small-scale anisotropy in the cosmic microwave background (CMB) are presented. Observations were made at the South Pole using the Viper telescope, with a 0. °26 (FWHM) beam and a passband centered at 40 GHz. Anisotropy band-power measurements in bands spanning the range of l in which the first acoustic peak is expected (bands centered at l = 108, 173, 237, 263, 422, and 589) are reported. Statistically significant CMB anisotropy is detected in all bands.
Low Overhead Interrupt Handling with SMT Threads

[4] introduces the Click modular router. Click is a software based router that is composed of flexible software modules. Click is designed to run on commodity hardware and in commodity operating systems. Click provides a motivation for our interrupt handling work as Click typifies the overhead problems with traditional OS interrupts. Click removes the interrupt handling completely, opting instead for a polling approach.
Abstracting Vector Architectures in Library Generators: Case Study Convolution Filters

We present FGen, a program generator for high performance convolution operations (finite-impulse-response filters). The generator uses an internal mathematical DSL to enable structural optimization at a high level of abstraction. We use FGen as a testbed to demonstrate how to provide modular and extensible support for modern SIMD vector architectures in a DSL-based generator. Specifically, we show how to combine staging and generic programming with type classes to abstract over both the data type (real or complex) and the target architecture (e.g., SSE or AVX) when mapping DSL expressions to C code with explicit vector intrinsics. Benchmarks shows that the generated code is highly competitive with commercial libraries.
Securing Audio Watermarking System using Discrete Fourier Transform for Copyright Protection

:- The recent growth in pc networks, and a lot of specifically, the planet Wide internet, copyright protection of digital audio becomes a lot of and a lot of necessary. Digital audio watermarking has drawn in depth attention for copyright protection of audio information. A digital audio watermarking may be a method of embedding watermarks into audio signal to point out genuineness and possession. Our technique supported the embedding watermark into audio signal and extraction of watermark sequence. We tend to propose a brand new watermarking system victimization separate Fourier remodel (DFT) for audio copyright protection. The watermarks area unit embedded into the best outstanding peak of the magnitude spectrum of every non-overlapping frame. This watermarking system can provides robust lustiness against many styles of attacks like noise addition, cropping, re-sampling, re-quantization, and MP3 compression and achieves similarity values starting from thirteen sound unit to twenty sound unit. Additionally, planned systems attempting to realize SNR (signal-to-noise ratio) values starting from twenty sound unit to twenty-eight sound unit.
Type X collagen gene regulation by Runx2 contributes directly to its hypertrophic chondrocyte–specific expression in vivo

The α1(X) collagen gene (Col10a1) is the only known hypertrophic chondrocyte–specific molecular marker. Until recently, few transcriptional factors specifying its tissue-specific expression have been identified. We show here that a 4-kb murine Col10a1 promoter can drive β-galactosidase expression in lower hypertrophic chondrocytes in transgenic mice. Comparative genomic analysis revealed multiple Runx2 (Runt domain transcription factor) binding sites within the proximal human, mouse, and chick Col10a1 promoters. In vitro transfection studies and chromatin immunoprecipitation analysis using hypertrophic MCT cells showed that Runx2 contributes to the transactivation of this promoter via its conserved Runx2 binding sites. When the 4-kb Col10a1 promoter transgene was bred onto a Runx2 +/− background, the reporter was expressed at lower levels. Moreover, decreased Col10a1 expression and altered chondrocyte hypertrophy was also observed in Runx2 heterozygote mice, whereas Col10a1 was barely detectable in Runx2-null mice. Together, these data suggest that Col10a1 is a direct transcriptional target of Runx2 during chondrogenesis.
Surface Recovery Using Curvature and Motion Consistency

A key problem in the recovery of scene descriptions from multiple views is the fusion of information from di erent vantage points. The contribution of this paper is a set of algorithms for reconstructing surfaces obtained from overlapping range images in a common frame of reference. Surfaces are assumed to be piecewise-smooth but not necessarily rigid. Motion parameters, rotations and translations that describe correspondence between views, are recovered locally under the assumption that the curvature structure at a point on a surface varies slowly under transformation. The recovery problem can thus be posed as nding the set of motion parameters that preserves curvature across two views. We show that an appropriate similarity functional can be devised that is convex in the vicinity of the true motion parameters. This leads to an e cient local algorithm that recovers motion parameters in gradient descent fashion.
Role of positron emission tomography in lung cancer

The ability to demonstrate tumour foci that are undetected by conventional imaging has resulted in the emergence of positron emission tomography (PET) as a valuable clinical tool in oncology. This article describes the technique and indications for fluorine-18 labelled fluorodeoxyglucose (18FDG)-PET in lung cancer, demonstrating the high accuracy and cost-effectiveness of 18FDG-PET in the characterisation of solitary pulmonary nodules and in the pre-operative staging of non-small cell lung cancer. Emerging roles in determination of prognosis, radiotherapy planning, therapy monitoring and diagnosis of recurrence are illustrated.
Personality predicts responsivity of the brain reward system.

Editor's Note: These short reviews of a recent paper in the Journal, written exclusively by graduate students or postdoctoral fellows, are intended to mimic the journal clubs that exist in your own departments or institutions. For more information on the format and purpose of the Journal Club, please see Review of Beaver et al. Food is a primary reward. There is no doubt that animals and humans find pleasure in the consumption of food and will work hard to obtain it under certain conditions. Foods differ in their rewarding value, with high-calorie foods typically being highly rewarding. In modern societies , food is readily available and food-related advertisements are ubiquitous. Thus, we can be easily motivated to consume rewarding foods even regardless of satiety. The over-consumption of appetizing high-caloric foods has contributed to the dramatic increase in obesity within the past 20 years, making obesity a top 10 global health threat, according to the World Health Organization. However, not everyone overeats. Individual differences in trait reward sensitivity are associated with increased food cravings, hyperphagia, and body weight (Davis et al., 2004). Reward sensitivity, a personality construct of Gray's biologically motivated Reinforcement Sensitivity Theory is thought to control approach behavior and has been linked to the meso-corticolimbic dopamine system (Picker-ing and Gray, 1999). Indeed, a network of interconnected brain regions consisting of orbitofrontal cortex, ventral striatum, amygdala, substantia nigra, and ventral tegmental area (Fig. 1) has repeatedly been implicated in mediating approach behaviors related to food reward in animals and humans. A recent study in The Journal of Neuroscience (Beaver et al., 2006) demonstrates a correlation between trait reward sensitivity and neural activity within the reward network. The authors showed that reward sensitivity , as assessed by the Behavioral Inhibition Scale/Behavioral Activation Scale, predicted neural responses to pictures of appetizing foods in the network of the brain regions outlined in Figure 1. Functional magnetic resonance imaging, in conjunction with a blocked experimental design, was used to record blood oxygenation-level dependent (BOLD) responses while participants passively viewed pictures of foods from four different categories. Volunteers were shown va-lenced pictures of food, which in separate studies were consistently rated as either highly appetizing and pleasant (appetizing foods) or highly disgusting and nauseating (disgusting foods). The comparison conditions included pictures of bland foods that were consistently rated as less pleasant and disgusting, as well as pictures of nonfood objects. Contrasting BOLD responses during experimental …
Dynamics of the surgical microbiota along the cardiothoracic surgery pathway

Human skin associated microbiota are increasingly described by culture-independent methods that showed an unexpected diversity with variation correlated with several pathologies. A role of microbiota disequilibrium in infection occurrence is hypothesized, particularly in surgical site infections. We study the diversities of operative site microbiota and its dynamics during surgical pathway of patients undergoing coronary-artery by-pass graft (CABG). Pre-, per-, and post-operative samples were collected from 25 patients: skin before the surgery, superficially and deeply during the intervention, and healing tissues. Bacterial diversity was assessed by DNA fingerprint using 16S rRNA gene PCR and Temporal Temperature Gel Electrophoresis (TTGE). The diversity of Operational Taxonomic Units (OTUs) at the surgical site was analyzed according to the stage of surgery. From all patients and samples, we identified 147 different OTUs belonging to the 6 phyla Firmicutes, Actinobacteria, Proteobacteria, Bacteroidetes, Cyanobacteria, and Fusobacteria. High variations were observed among patients but common themes can be observed. The Firmicutes dominated quantitatively but were largely encompassed by the Proteobacteria regarding the OTUs diversity. The genera Propionibacterium and Staphylococcus predominated on the preoperative skin, whereas very diverse Proteobacteria appeared selected in peri-operative samples. The resilience in scar skin was partial with depletion in Actinobacteria and Firmicutes and increase of Gram-negative bacteria. Finally, the thoracic operative site presents an unexpected bacterial diversity, which is partially common to skin microbiota but presents particular dynamics. We described a complex bacterial community that gathers pathobionts and bacteria deemed to be environmental, opportunistic pathogens and non-pathogenic bacteria. These data stress to consider surgical microbiota as a “pathobiome” rather than a reservoir of individual potential pathogens.
Treatment and survival patterns of Chinese patients diagnosed with breast cancer between 2005 and 2009 in Southwest China

AbstractBreast cancer is a significant health issue both globally and within China. Here, we present epidemiological data for female patients diagnosed with breast cancer and treated at West China Hospital, Sichuan University, between 2005 and 2009. Patients who were diagnosed with breast cancer between 2005 and 2009 were enrolled. Data cut-off in this analysis was October 2013, allowing a minimum of 3 years’ follow-up, or follow-up until death. Data were collected and subject to statistical analyses to assess relationships between patient and cancer characteristics, treatment patterns and long-term outcomes. A total of 2252 women with breast cancer were included in the analyses. Luminal B was the most common subtype of breast cancer and human epidermal growth factor 2 (HER2)-positive (nonluminal) was the least common. Most patients had early-stage disease (stage ⩽IIIa) at diagnosis. Patients with luminal A appeared to have the best overall survival (OS), compared with other subtypes. Hormone-receptor positivity was associated with improved prognosis, compared with negativity (OS hazard ratio [HR] 0.5). Late-stage compared with early-stage disease at diagnosis was associated with much poorer OS across all patients and tumor subtypes. Clear differences were apparent between breast cancer subtypes and the response to treatment. The interaction of breast cancer subtypes, treatments and disease stage is complex. One of the most important factors for improved prognosis is diagnosis and treatment at an early-stage of disease. With breast cancer becoming an increasingly important health concern, this highlights the importance of establishing systems and protocols to identify and treat patients with breast cancer as early as possible.
A non-orthogonal projection approach to characterization of almost positive real systems with an application to adaptive control

We develop a very general projection approach to obtain and unify necessary and sufficient conditions for making a linear time-invariant system positive real using static output feedback. Such systems are called "almost positive real". These conditions are that the open-loop system must be weakly minimum phase, have positive definite high frequency gain and the marginally stable zero system alone must be positive real. When dynamic output feedback is used the necessary and sufficient conditions reduce to weakly minimum phase with a positive definite high frequency gain. These results yield a stability proof for direct model reference adaptive control and disturbance cancellation using only almost positive real systems.