Miracle-dz/UniFAR-FTUs huggingface dataset:
Interaction between pedestrians and automated vehicles: Perceived safety of yielding behaviors and benefits of an external human–machine interface for elderly people

This study focuses on Automated Vehicles (AVs) interactions with pedestrians during road crossing situations. A dual-phase experiment was designed: one from the pedestrian’s perspective and the other one from the AV passenger’s point of view. Eight AV behaviors to yield were investigated. Participants’ task was to assess the safety of each one of these yielding behaviors. Moreover, an external HMI (eHMI) was designed to support them in these interactions. 40 participants were involved in this experiment (50% females, 20 young versus 20 elderly). Results obtained show significant differences between old and young participants: elderly people have not the same way to perceive and assess the safety of the yielding behaviors from “the inside” and from “the outside” of the car. Conversely, young participants assessed AV behaviors similarly whether as pedestrians or as AV passengers. When considering benefits introduced by the eHMI, it significantly reduces differences between old and young participants and tends to harmonize their safety assessments: with to the eHMI, elderly people are more able to adequately perceive and assess the safety/dangerousness of the AV braking manoeuvers, and their safety judgments become at last quite similar to those of young participants. Moreover, the eHMI increases participants’ Acceptance of AV and reduces their concerns about their future interactions with AV as a pedestrian, especially for elderly people.
AN EXPERIMENT TO LOCATE THE SITE OF TeV FLARING IN M87

We describe a Chandra X-ray target-of-opportunity project designed to isolate the site of TeV flaring in the radio galaxy M87. To date, we have triggered the Chandra observations only once (2010 April) and by the time of the first of our nine observations, the TeV flare had ended. However, we found that the X-ray intensity of the unresolved nucleus was at an elevated level for our first observation. Of the more than 60 Chandra observations we have made of the M87 jet covering nine years, the nucleus was measured at a comparably high level only three times. Two of these occasions can be associated with TeV flaring, and at the time of the third event, there were no TeV monitoring activities. From the rapidity of the intensity drop of the nucleus, we infer that the size of the emitting region is of order a few light days × the unknown beaming factor; comparable to the same sort of estimate for the TeV emitting region. We also find evidence of spectral evolution in the X-ray band which seems consistent with radiative losses affecting the non-thermal population of the emitting electrons within the unresolved nucleus.
Exploring the molecular mechanism of hepatitis virus inducing hepatocellular carcinoma by microarray data and immune infiltrates analysis

The number of new cases of hepatocellular carcinoma (HCC) worldwide reached 910,000, ranking the sixth, 80% HCC is associated with viruses, so exploring the molecular mechanism of viral carcinogenicity is imperative. The study showed that both HBV and HCV associated HCC and non-viral HCC have the same molecular phenotype (low gene expression and inhibition of immune pathways), but in the tumor immune micro-environment, there is excessive M2-type macrophage polarization in virus-associated hepatocellular carcinoma. To address this phenomenon, the data sets were analyzed and identified five hub genes (POLR2A, POLR2B, RPL5, RPS6, RPL23A) involved in viral gene expression and associated with PI3K-Akt-mTOR pathway activation by six algorithms. In addition, numerous studies have reported that M2-type macrophages participate in the hepatic fibro-pathological process of the development of HCC and are regulated by the PI3K-Akt-mTOR pathway. On this basis, the study showed that hepatitis virus causes abnormal expression of hub genes, leading to the activation of the pathway, which in turn promote the differentiation of M2-type macrophages and eventually promote the formation of liver fibrosis, leading to the occurrence of HCC. In addition, these hub genes are regulated by transcription factors and m6A enzyme, and have good prognosis and diagnostic value. With regard to drug reuse, the results suggest that patients with virus-related HCC for whom Cytidine triphosphate disodium salt and Guanosine-5’-Triphosphate are used as supplementary therapy, and may have a better prognosis. In conclusion, the study has identified novel molecules that are carcinogenic to hepatitis viruses and are expected to serve as molecular markers and targets for diagnosis and treatment.
The variability of volatile organic compounds during a persistent fog-haze episode

A persistent fog-haze process associated with high pollution occurred in the northern suburbs of Nanjing from November to December 2013. Based on the comprehensive chemical and microphysical observations during the intense observation period, the composition characteristics, and variation rules of volatile organic compounds (VOCs) in the atmosphere under four weather conditions (slight haze, haze, fog, and dense fog) were compared and analyzed, the influencing factors for VOCs during extremely dense fog were discussed in more detail. The average concentrations of VOCs displayed as alkanes > aromatics > alkenes > alkynes, and their concentrations were ranked as dense fog > fog > haze > slight haze, the main factor contributing to the difference in concentrations of VOCs under different weather conditions is the boundary layer characteristics and photochemical reaction rate. Microphysical parameters such as liquid water content (LWC) were negatively correlated with VOCs concentration in dense fog (LWC>0.008 g m−3). Also, the concentration of VOCs showed an oscillating decrease in extremely dense fog (LWC>0.12 g m−3), and the total VOCs removal rate was close to 30%, which may be attributed to an indirect/direct removal effect, in which the enhanced collision and deposition of fog droplets promote the redistribution of VOCs gas-aqueous/particle partitioning, and remove them from the atmosphere by fog water.
Comprehensive analysis of the prognostic value and functions of prefoldins in hepatocellular carcinoma

Prefoldins (PFDNs), a group of proteins known to be associated with cytoskeletal rearrangement, are involved in tumor progression in various cancer types. However, little is known about the roles of PFDNs in hepatocellular carcinoma (HCC). Herein, we investigated the transcriptional and survival data of PFDNs from The Cancer Genome Atlas (TCGA) database. Gene Ontology (GO), Gene Set Enrichment Analysis (GSEA), and single-sample gene set enrichment analysis (ssGSEA) were used to evaluate the potential functions of PFDN1/2/3/4. We also detected the expression of PFDN1/2/3/4 via immunohistochemistry (IHC), Western blotting, and real-time PCR in our clinical samples. We found that the PFDN family showed elevated expression in HCC tissues, while only PFDN1/2/3/4 were found to be significantly correlated with poor prognosis of patients with HCC in the TCGA database. Further investigation was associated with PFDN1–4. We found that the expression of PFDN1/2/3/4 was significantly associated with advanced clinicopathologic features. Apart from the TCGA database, IHC, real-time PCR, and immunoblotting identified the overexpression of PFDN1/2/3/4 in HCC tissues and HCC cell lines. Taken together, these results indicated that PFDN1/2/3/4 might be novel prognostic biomarkers and treatment targets for patients with HCC.
Rigid bioplastics shape the microbial communities involved in the treatment of the organic fraction of municipal solid waste

While bioplastics are gaining wide interest in replacing conventional plastics, it is necessary to understand whether the treatment of the organic fraction of municipal solid waste (OFMSW) as an end-of-life option is compatible with their biodegradation and their possible role in shaping the microbial communities involved in the processes. In the present work, we assessed the microbiological impact of rigid polylactic acid (PLA) and starch-based bioplastics (SBB) spoons on the thermophilic anaerobic digestion and the aerobic composting of OFMSW under real plant conditions. In order to thoroughly evaluate the effect of PLA and SBB on the bacterial, archaeal, and fungal communities during the process, high-throughput sequencing (HTS) technology was carried out. The results suggest that bioplastics shape the communities’ structure, especially in the aerobic phase. Distinctive bacterial and fungal sequences were found for SBB compared to the positive control, which showed a more limited diversity. Mucor racemosus was especially abundant in composts from bioplastics’ treatment, whereas Penicillium roqueforti was found only in compost from PLA and Thermomyces lanuginosus in that from SBB. This work shed a light on the microbial communities involved in the OFMSW treatment with and without the presence of bioplastics, using a new approach to evaluate this end-of-life option.
Circulating microRNA responses to acute whole-body vibration and resistance exercise in postmenopausal women

Evaluating alterations in circulating microRNA (c-miRNA) expression may provide deeper insight into the role of exercise in the attenuation of the negative effects of aging on musculoskeletal health. Currently, there are sparse data on c-miRNA responses to acute exercise in postmenopausal women. The purpose of this study was to characterize the effects of acute bouts of resistance exercise and whole-body vibration on expression of selected c-miRNAs in postmenopausal women aged 65-76 years (n=10). We also examined relationships between c-miRNAs and muscle strength and bone characteristics. This randomized crossover design study compared c-miRNA responses to a bout of resistance exercise (RE) (3 sets 10 reps 70% 1 repetition maximum (1RM), 5 exercises) and a bout of whole-body vibration (WBV) (5 sets 1 min bouts 20Hz 3.38mm peak to peak displacement, Vibraflex vibration platform). DXA was used to measure body composition and areal bone mineral density (aBMD) of the total body, AP lumbar spine, and dual proximal femur. pQCT was used to measure tibia bone characteristics (4%, 38%, 66% sites). Blood samples were collected before exercise (Pre), immediately-post (IP), 60 minutes post (60P), 24 hours (24H), and 48 hours (48H) after exercise to measure serum miR-21-5p, -23a-3p, -133a-3p, -148a-3p (qPCR) and TRAP5b (ELISA). There was a significant modality × time interaction for c-miR-21-5p expression (p=0.019), which decreased from 60P to 24H after WBV only. TRAP5b serum concentrations significantly increased IP then decreased below Pre at 24H for both WBV and RE (p<0.01). Absolute changes in TRAP5b were negatively correlated with c-miR-21-5p fold changes (r= -0.642 to -0.724, p<0.05) for both exercise modalities. There were significant negative correlations between baseline c-miRNAs and bone status variables (r= -0.639 to -0.877, p<0.05). Our findings suggest that whole-body vibration is a sufficient mechanical stimulus for altering c-miR-21-5p expression, whereas a high intensity resistance exercise protocol did not elicit any c-miRNA responses in postmenopausal women. Increases in the bone resorption marker, TRAP5b, were associated with greater downregulation of c-miR-21-5p expression.
Symmetries in discrete time quantum walks on Cayley graphs

We address the question of symmetries of an important type of quantum walks. We introduce all the necessary definitions and provide a rigorous formulation of the problem. Using a thorough analysis, we reach the complete answer by presenting a constructive method of finding all solutions of the problem with minimal additional assumptions. We apply the results on an example of a quantum walk on a line to demonstrate the practical significance of the theory.
Acceptability of an internet-delivered intervention for adjustment disorder and its role as predictor of efficacy

Background: Internet-delivered interventions offer a feasible way to facilitate access to mental healthcare and considerable evidence supports their effectiveness for the treatment of different mental disorders. However, potential users’ attitudes toward these interventions are crucial for their successful implementation. A better understanding of factors related to treatment acceptance and adherence is required to exploit the full potential of internet interventions. Hence, the aim of the present work was to analyze the acceptability of a therapist-guided internet-delivered CBT intervention for adjustment disorder and its impact on treatment outcomes. Methods: The acceptability was estimated from the acceptance to participate in the randomized controlled trial addressed to explore the effectiveness of the internet intervention in question. Other indicators of acceptability were treatment adherence, expectations, satisfaction, and opinion reported by 34 participants from the trial. Results: Willingness to try an internet intervention was observed and 76.5% of participants completed all seven treatment modules. Less positive initial expectations did not reduce treatment effectiveness, yet they might have led to treatment abandonment. Overall, participants were satisfied with the internet intervention and perceived it as a useful, comfortable and attractive way of receiving psychological assistance. Treatment modules aimed at promoting identification with the treatment goals, relapse prevention, and change in the meaning of the stressor were found to be related to posttraumatic growth and increase in positive affect and quality of life. Participants also expressed that the intervention required considerable motivation. In this regard, therapeutic support was perceived as an important adherence facilitator. Conclusion: The findings from this work support the suitability of internet interventions for the treatment of adjustment disorder. However, further research is required in order to develop guidelines for the design of more attractive and engaging internet interventions.
Clinically encountered growth phenotypes of tuberculosis-causing bacilli and their in vitro study: A review

The clinical manifestations of tuberculosis (TB) vary widely in severity, site of infection, and outcomes of treatment—leading to simultaneous efforts to individualize therapy safely and to search for shorter regimens that can be successfully used across the clinical spectrum. In these endeavors, clinicians and researchers alike employ mycobacterial culture in rich media. However, even within the same patient, individual bacilli among the population can exhibit substantial variability in their culturability. Bacilli in vitro also demonstrate substantial heterogeneity in replication rate and cultivation requirements, as well as susceptibility to killing by antimicrobials. Understanding parallels in clinical, ex vivo and in vitro growth phenotype diversity may be key to identifying those phenotypes responsible for treatment failure, relapse, and the reactivation of bacilli that progresses TB infection to disease. This review briefly summarizes the current role of mycobacterial culture in the care of patients with TB and the ex vivo evidence of variability in TB culturability. We then discuss current advances in in vitro models that study heterogenous subpopulations within a genetically identical bulk culture, with an emphasis on the effect of oxidative stress on bacillary cultivation requirements. The review highlights the complexity that heterogeneity in mycobacterial growth brings to the interpretation of culture in clinical settings and research. It also underscores the intricacies present in the interplay between growth phenotypes and antimicrobial susceptibility. Better understanding of population dynamics and growth requirements over time and space promises to aid both the attempts to individualize TB treatment and to find uniformly effective therapies.
Methylation-based reclassification and risk stratification of skull-base chordomas

Background Skull-base chordomas are rare malignant bone cancers originating from the remnant of the notochord. Survival is variable, and clinical or molecular factors cannot reliably predict their outcomes. This study therefore identified epigenetic subtypes that defined new chordoma epigenetic profiles and their corresponding characteristics. Methods Methylation profiles of 46 chordoma-resected neoplasms between 2008 and 2014, along with clinical information, were collected. K-means consensus clustering and principal component analysis were used to identify and validate the clusters. Single-sample gene set enrichment analysis, methylCIBERSORT algorithm, and copy number analysis were used to identify the characteristics of the clusters. Results Unsupervised clustering analysis confirmed two clusters with a progression-free survival difference. Gene set enrichment analysis indicated that the early and late estrogen response pathways and the hypoxia pathway were activated whereas the inflammatory and interferon gamma responses were suppressed. Forty-six potential therapeutic targets corresponding to differentially methylated sites were identified from chordoma patients. Subgroups with a worse outcome were characterized by low immune cell infiltration, higher tumor purity, and higher stemness indices. Moreover, copy number amplifications mostly occurred in cluster 1 tumors and the high-risk group. Additionally, the presence of a CCNE1 deletion was exclusively found in the group of chordoma patients with better outcome, whereas RB1 and CDKN2A/2B deletions were mainly found in the group of chordoma patients with worse outcome. Conclusions Chordoma prognostic epigenetic subtypes were identified, and their corresponding characteristics were found to be variable.
Endothelial cilia dysfunction in pathogenesis of hereditary hemorrhagic telangiectasia

Hereditary hemorrhagic telangiectasia (HHT) is associated with defective capillary network, leading to dilated superficial vessels and arteriovenous malformations (AVMs) in which arteries connect directly to the veins. Loss or haploinsufficiency of components of TGF-β signaling, ALK1, ENG, SMAD4, and BMP9, have been implicated in the pathogenesis AVMs. Emerging evidence suggests that the inability of endothelial cells to detect, transduce and respond to blood flow, during early development, is an underpinning of AVM pathogenesis. Therefore, components of endothelial flow detection may be instrumental in potentiating TGF-β signaling in perfused blood vessels. Here, we argue that endothelial cilium, a microtubule-based and flow-sensitive organelle, serves as a signaling hub by coupling early flow detection with potentiation of the canonical TGF-β signaling in nascent endothelial cells. Emerging evidence from animal models suggest a role for primary cilia in mediating vascular development. We reason, on recent observations, that endothelial cilia are crucial for vascular development and that embryonic loss of endothelial cilia will curtail TGF-β signaling, leading to associated defects in arteriovenous development and impaired vascular stability. Loss or dysfunction of endothelial primary cilia may be implicated in the genesis of AVMs due, in part, to inhibition of ALK1/SMAD4 signaling. We speculate that AVMs constitute part of the increasing spectrum of ciliopathy-associated vascular defects.
Intrinsic scatter of caustic masses and hydrostatic bias: An observational study

All estimates of cluster mass have some intrinsic scatter and perhaps some bias with true mass even in the absence of measurement errors for example caused by cluster triaxiality and large scale structure. Knowledge of the bias and scatter values is fundamental for both cluster cosmology and astrophysics. In this paper we show that the intrinsic scatter of a mass proxy can be constrained by measurements of the gas fraction because masses with higher values of intrinsic scatter with true mass produce more scattered gas fractions. Moreover, the relative bias of two mass estimates can be constrained by comparing the mean gas fraction at the same (nominal) cluster mass. Our observational study addresses the scatter between caustic (i.e., dynamically estimated) and true masses, and the relative bias of caustic and hydrostatic masses. For these purposes, we used the X-ray Unbiased Cluster Sample, a cluster sample selected independently from the intracluster medium content with reliable masses: 34 galaxy clusters in the nearby ($0.050<z<0.135$) Universe, mostly with $14<\log M_{500}/M_\odot \lesssim 14.5$, and with caustic masses. We found a 35\% scatter between caustic and true masses. Furthermore, we found that the relative bias between caustic and hydrostatic masses is small, $0.06\pm0.05$ dex, improving upon past measurements. The small scatter found confirms our previous measurements of a highly variable amount of feedback from cluster to cluster, which is the cause of the observed large variety of core-excised X-ray luminosities and gas masses.
Computational prediction of lattice thermal conductivity: A comparison of molecular dynamics and Boltzmann transport approaches

The predictive modeling of lattice thermal conductivity is of fundamental importance for the understanding and design of materials for a wide range of applications. Two major approaches, namely molecular dynamics (MD) simulations and calculations solving approximately the Boltzmann transport equation (BTE), have been developed to compute the lattice thermal conductivity. We present a detailed direct comparison of these two approaches, using as prototypical cases MgO and PbTe. The comparison, carried out using empirical potentials, takes into account the effects of fourth order phonon scattering, temperature-dependent phonon frequencies (phonon renormalization), and investigates the effects of quantum vs. classical statistics. We clarify that equipartition, as opposed to Maxwell Boltzmann, govern the statistics of phonons in MD simulations. We find that lattice thermal conductivity values from MD and BTE show an apparent, satisfactory agreement; however such an agreement is the result of error cancellations. We also show that the primary effect of statistics on thermal conductivity is via the scattering rate dependence on phonon populations.
Unveiling the nature of INTEGRAL objects through optical spectroscopy - X. A new multi-year, multi-observatory campaign

Within the framework of our program (running since 2004) of identification of hard X-ray INTEGRAL sources through optical spectroscopy, we present the results concerning the nature of 33 high-energy objects. The data were acquired with the use of six telescopes of different sizes and from one on-line archive. The results indicate that the majority of these objects (23 out of 33) are active galactic nuclei (AGNs), whereas 10 are sources in the local Universe with eight of which in the Galaxy and two in the Small Magellanic Cloud (SMC). Among the identified AGNs, 13 are of Type 1 (i.e., with broad emission lines), eight are of Type 2 (with narrow emissions only), and two are X-ray bright, optically normal galaxies with no apparent nuclear activity in the optical. Six of these AGNs lie at high redshift (z>0.5). Concerning local objects, we found that five of them are Galactic cataclysmic variables, three are high-mass X-ray binaries (two of which lying in the SMC), one is a low-mass X-ray binary, and one is classified as a flare star that is likely of RS CVn type. The main optical properties and inferred physical characteristics of these sources are presented and discussed.