Miracle-dz/UniFAR-FTUs huggingface dataset:
Adaptive multimodal biosignal control for exoskeleton supported stroke rehabilitation

A relevant issue of neuro-interfacing wearable robots in rehabilitation is the necessity to have training data, since the collection of sufficient data from patients within a reasonable recording time is not always possible. However, the use of historic data (e.g., session-to-session transfer, subject-to-subject transfer) can often lead to a reduction in classification performance which is affected by the selection of the historic data (i.e., which historic data was chosen for transfer). In this paper, we analyze two approaches to handle this reduction. First, we used incremental algorithms that can be adapted to the current session when trainable components (the spatial filter and the classifier) are transferred between different sessions. Second, we increased the number of sessions to learn more generalized models. To evaluate the approaches, we used electroencephalographic data that was recorded as training data for demonstrating our neuro-interfacing wearable robot in the application of upper-body sensorimotor rehabilitation. The data was collected from the same healthy subject on 14 different days (14 sessions). Our results showed that the use of a mixture of training sessions improved the classification performance. Further, we could show that the adaptive approaches contributed to less variability in performance that allows the system to be more robust. Hence, one can efficiently use both approaches (i.e., adapting and generalizing the models) depending on how much training data is available. Finally, the analyzed approaches are very promising to increase system applicability in upper-body sensorimotor robotic rehabilitation.
Housing Supply Elasticity in Sydney Local Government Areas

We report supply elasticity estimates of residential property (houses and apartments) for Local Government Areas (LGAs) in metropolitan Sydney. Using annual data for 1991-2012, the average supply elasticity estimate across all LGAs is 0.2 for houses and 0.8 for apartments. The supply ofhouses is inelastic in all 43 LGAs; in contrast apartment supply is elastic – greater than unity – in about one-third of LGAs. We develop a model to explain the cross-section variation in supply elasticity across LGAs. For houses, supply elasticity is negatively related to an LGA’s population density, the time taken by a Local Council to process a development application and to various measures of the amount of land in an LGA that is unavailable for new housing development. Variation in supply elasticity for apartments across LGAs is unrelated to any of the available regressors.
Scientific Team Effectiveness and the External CEO

This paper presents an empirical exploration of the effectiveness of scientific teams and the role of an external CEO in the spin-off formation process. The paper contributes to the literature by focusing on the role of the experienced or ‘external’ entrepreneur (their commercial resources and capabilities) in the early phase of spin-off formation and offering an attempt to understand the interaction between scientific team effectiveness and the external CEO. The data are drawn from the BioPartner First Stage Grant, a seed fund initiated in the Netherlands that aims to stimulate university spin-offs in biotechnology. This unique data set covers 68 biotechnology spin-off projects and the results show that an external CEO positively influences the spin-off creation and leverages the effect of the spin-off's scientific quality.
Why Do We Observe Stockless Operations on the Internet? Stockless Operations Under Competition

Due to the proliferation of electronic commerce and the development of Internet technologies, many firms have considered new pricing‐inventory models. In this paper, we study the role of stockless (i.e., zero‐inventory) operations in online retailing by a considering duopoly competition in which two retailers compete to maximize profit by jointly optimizing their pricing and inventory decisions. In our model, the retailers are allowed to choose either an in‐stock policy or stockless operations with a discounted price. We first present the characteristics and properties of the equilibrium. We then demonstrate that the traditional outcome of asymmetric Bertrand competition is observed under head‐to‐head competition. However, when the two firms choose different operational policies, with corresponding optimal pricing, they can share the market under certain conditions. Finally, we report interesting observations on the interaction between pricing and inventory decisions obtained from an extensive computational study.
Proteoglycans secreted by packaging cell lines inhibit retrovirus infection

Using a model recombinant retrovirus encoding the Escherichia coli lacZ gene, we have found that medium conditioned with NIH 3T3 cells and packaging cell lines derived from NIH 3T3 cells inhibits infection. Most of the inhibitory activity was greater than 100 kDa and was sensitive to chondroitinase ABC digestion, which is consistent with the inhibitor being a chondroitin sulfate proteoglycan. Proteoglycans secreted by NIH 3T3 cells and purified by anion-exchange chromatography inhibited amphotropic retrovirus infection. Pretreatment of amphotropic retrovirus stocks with chondroitinase ABC boosted the level of transduction efficiency by more than twofold. The implications of these findings with respect to retrovirus-cell interactions and the production of high-titer retroviral stocks are discussed.
A Perithecial Sordariomycete (Ascomycota, Diaporthales) from the Lower Cretaceous of Vancouver Island, British Columbia, Canada

A perithecial ascomycete, Spataporthe taylori gen. et sp. nov., represented by >70 sporocarps is preserved by cellular permineralization in marine carbonate concretions dated at the Valanginian-Hauterivian boundary (Early Cretaceous) from Vancouver Island, British Columbia, Canada. The spheroid perithecia with lumina 330–470 μm wide and 220–320 μm high are densely distributed and entirely immersed in the tissues of a coniferous leaf. The perithecial wall consists of an outer layer of large pseudoparenchyma and an inner layer of thin filamentous nature. Perithecial necks are incompletely preserved due to taphonomic abrasion; they have a bell-shaped chamber at the base and a narrow channel, with longitudinally aligned hyphae above. The basal chamber of the neck is filled with a plug of pseudoparenchyma, which subsequently disintegrates to form a peripheral collar; periphyses are present on the basal chamber walls. A pseudoparenchymatous hymenium lines the bottom of perithecia. Asci are clavate, with thinly tapered bases, and small (30–47 μm long and 12–20 μm wide at tip), ornamented with minute papillae. They become detached from the hymenium to float freely in the perithecium. No unequivocal ascospores were found, although smaller units are present in some of the asci. The combination of immersed perithecia with complex wall structure and a well-defined hymenium, absence of paraphyses, and persistent, detachable inoperculate asci is consistent with order Diaporthales of class Sordariomycetes. The small clavate asci are comparable to those found in family Gnomoniaceae. Perithecioid ascomata are rare in the fossil record, and bona fide perithecia are known with certainty only from the Early Devonian Rhynie Chert and Cenozoic amber. Spataporthe taylori contributes a well-characterized Early Cretaceous occurrence, which is also the oldest to date, to the scarce fossil record of the Sordariomycetes and a second taxon to the fungal flora of the locality, which also includes a basidiomycete. As the oldest representative of the Diaporthales, Spataporthe provides a minimum age (136 Ma) for the order and a direct calibration point for studies of divergence times in the ascomycetes.
An alternative receptor to poly I:C on cell surfaces for interferon induction

Not‐self or denatured nucleic acids are recognized by pattern recognition receptors localized mainly in endosomes and cytoplasm, such as Toll‐like receptor (TLR) 3, TLR7, TLR9, retinoic acid‐inducible gene‐I, DNA‐dependent activator of IFN‐regulatory factors and other receptors. The binding of polyriboinosinic:polyribocytidylic acid (poly I:C), a synthetic dsRNA that robustly induces type I interferon, to a putative cell‐surface receptor on a rabbit kidney cell line, RK13, has been analyzed by the authors and RK13 cells found to capture poly I:C in a specific fashion with sufficient affinity. These findings suggest that an alternative receptor to poly I:C participates in the induction of type 1 interferon, which localizes on cell surfaces. Although the nature of this molecule has not yet been identified, accumulating evidence has led the present authors to speculate that there are undefined classes of RNA‐recognition molecules on cell surfaces and that these are unlikely to be categorized as previously reported dsRNA receptors. Although many years have passed since this possibility was first reported by the present authors, it remains attractive. In this article, previously reported cell‐surface dsRNA receptors are reviewed in comparison with other receptors reported to date that are firmly involved in the innate immune‐sensing of nucleic acids.
OFFSETTING NEW CO2 EMISSIONS: A RATIONAL FIRST GREENHOUSE POLICY STEP

This paper describes and assesses a policy to slow the increase of carbon dioxide (CO2) emissions in the atmosphere. Policy governing new CO2 sources would either prevent emissions, procure compensating emissions reductions, or sequester emissions in sinks. The paper uses electric power plants to demonstrate the mechanics of the policy and the control or offset choices. Offset options include scrubbing, fuel switching, investments in energy conservation and efficiency, and afforestation. Costs per ton ofC02 sequestered range from $1.35 for planting shade trees to $59.41 for scrubbing. All options except scrubbing cost less than $11.00, and the median cost is around $6.00 per ton removed. Planting trees on erodible cropland in conjunction with the Conservation Reserve Program combines the goals of reduced erosion, surplus agricultural production, and greenhouse warming. This policy is a first sane step toward reducing the accumulation of greenhouse gases. Having an international framework for managing emissions is most desirable. In the interim, however, the United States can demonstrate environmental leadership, generate substantial conservation benefits, and spark ingenuity in searching for alternatives, broadening the options, and lowering the ultimate costs of reducing CO2 emissions.
Infant Mortality in Uruguay: The Effect of Socioeconomic Status on Survival

This paper analyzes infant mortality in a unique and highly-detailed data set from Uruguay. A duration model is employed to estimate the relationships between infant mortality and socioeconomic status at the individual, household, and community level. Our results indicate that the most important predictors of infant survival in the first year of life are a full gestational period, mother’s educational attainment, marital status (a proxy for family wealth), and the type of hospital used for delivery. We also find that the region where the mother resides (a proxy for community wealth), whether or not the delivery was a multiple delivery, and the gender of the infant are strong predictors of infant mortality in Uruguay. In light of the United Nations Millennium Development Goals, the results presented in this paper suggest that policies designed to increase women’s education and to decrease out-of-wedlock births can substantially improve infant health in less-developed countries.
Genetic manipulation of cardiac ageing

Ageing in humans is associated with a significant increase in the prevalence of cardiovascular disease. We still do not fully understand the molecular mechanisms underpinning this correlation. However, a number of insights into which genes control cardiac ageing have come from studying hearts of the fruit fly, Drosophila melanogaster. The fly's simple heart tube has similar molecular structure and basic physiology to the human heart. Also, both fly and human hearts experience significant age‐related morphological and functional decline. Studies on the fly heart have highlighted the involvement of key nutrient sensing, ion channel and sarcomeric genes in cardiac ageing. Many of these genes have also been implicated in ageing of the mammalian heart. Genes that increase oxidative stress, or are linked to cardiac hypertrophy or neurodegenerative diseases in mammals also affect cardiac ageing in the fruit fly. Moreover, fly studies have demonstrated the potential of exercise and statins to treat age‐related cardiac disease. These results show the value of Drosophila as a model to discover the genetic causes of human cardiac ageing.
A randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in men.

BACKGROUND Topical minoxidil solution 2% stimulates new hair growth and helps stop the loss of hair in individuals with androgenetic alopecia (AGA). Results can be variable, and historical experience suggests that higher concentrations of topical minoxidil may enhance efficacy. OBJECTIVE The purpose of this 48-week, double-blind, placebo-controlled, randomized, multicenter trial was to compare 5% topical minoxidil with 2% topical minoxidil and placebo in the treatment of men with AGA. METHODS A total of 393 men (18-49 years old) with AGA applied 5% topical minoxidil solution (n = 157), 2% topical minoxidil solution (n = 158), or placebo (vehicle for 5% solution; n = 78) twice daily. Efficacy was evaluated by scalp target area hair counts and patient and investigator assessments of change in scalp coverage and benefit of treatment. RESULTS After 48 weeks of therapy, 5% topical minoxidil was significantly superior to 2% topical minoxidil and placebo in terms of change from baseline in nonvellus hair count, patient rating of scalp coverage and treatment benefit, and investigator rating of scalp coverage. Hair count data indicate that response to treatment occurred earlier with 5% compared with 2% topical minoxidil. Additionally, data from a patient questionnaire on quality of life, global benefit, hair growth, and hair styling demonstrated that 5% topical minoxidil helped improve patients' psychosocial perceptions of hair loss. An increased occurrence of pruritus and local irritation was observed with 5% topical minoxidil compared with 2% topical minoxidil. CONCLUSION In men with AGA, 5% topical minoxidil was clearly superior to 2% topical minoxidil and placebo in increasing hair regrowth, and the magnitude of its effect was marked (45% more hair regrowth than 2% topical minoxidil at week 48). Men who used 5% topical minoxidil also had an earlier response to treatment than those who used 2% topical minoxidil. Psychosocial perceptions of hair loss in men with AGA were also improved. Topical minoxidil (5% and 2%) was well tolerated by the men in this trial without evidence of systemic effects.
A randomised controlled trial of the effect of music therapy and verbal relaxation on chemotherapy-induced anxiety.

AIMS To determine the effect of music therapy and verbal relaxation on state anxiety and anxiety-induced physiological manifestations among patients with cancer before and after chemotherapy. BACKGROUND Cancer and its treatment provoke a series of changes in the emotional sphere of the patient's anxiety. Music therapy and verbal relaxation had reported the anxiety reduction effect on patients with cancer receiving chemotherapy. Few studies have been undertaken comparing music therapy and verbal relaxation in differentiating high-normal state anxiety subsample. DESIGN A randomised controlled trial and permuted block design were used. Outpatient chemotherapy clinic operated by a University medical centre in southern Taiwan. METHODS Ninety-eight patients were randomised into three groups: the music therapy group received one-hour single music session; the verbal relaxation group received 30 minutes of guided relaxation; the control group received usual care. Spielberger State-Trait Anxiety Instrument, Emotional Visual Analog Scale, three biobehavioural indicators: skin temperature, heart rate and consciousness level were measured during and after chemotherapy. RESULT Music therapy had a greater positive effect on postchemotherapy anxiety than verbal relaxation and control groups and a significantly increase in skin temperature. Patients with high state anxiety receiving music therapy had a greater drop in postchemotherapy anxiety than did the normal state anxiety subsample. CONCLUSIONS Both music and verbal relaxation therapy are effective in reducing chemotherapy-induced anxiety. Thirty minutes of intervention initiates anxiety reduction. Patients with high state anxiety receiving chemotherapy obtain the most benefit from music or verbal relaxation. RELEVANCE TO CLINICAL PRACTICE Prior to chemotherapy, patients with high state anxiety must be sorted from all patients as they are more responsive to interventions. Oncology nurses can offer music and verbal relaxation as adjuvant interventions to reduce chemotherapy-induced anxiety and enhance the quality of care.
An account of responses of spectrally opponent neurons in macaque lateral geniculate nucleus to successive contrast

Coloured surfaces in the normal environment may be brighter or dimmer than the mean adaptation level. Changes in the firing rate of cells of the parvocellular layers of macaque lateral geniculate nucleus were studied with such stimuli; chromatic mixtures briefly replaced a white adaptation field. This paradigm is therefore one of successive contrast. Families of intensity-response curves for different wavelengths were measured. When taking sections at different luminance ratios through these families of curves, strongly opponent cells displayed spectrally selective responses at low luminance ratios, while weakly opponent cells had higher chromatic thresholds and responded well to stimuli at higher luminance ratios, brighter than the adaptation field. Strength of cone opponency, defined as the weight of the inhibitory cone mechanism relative to the excitatory one, was thus related to the range of intensity in which cells appeared to operate most effectively. S-cone inputs, as tested with lights lying along tritanopic confusion lines, could either be excitatory or inhibitory. Families of curves for different wavelengths can be simulated mathematically for a given cell by a simple model by using known cone absorption spectra. Hyperbolic response functions relate cone absorption to the output signals of the three cone mechanisms, which are assumed to interact linearly. Parameters from the simulation provided estimates of strength of cone opponency and cone sensitivity which were shown to be continuously distributed. Cell activity can be related to cone excitation in a trichromatic colour space with the help of the model, to give an indication of suprathreshold coding of colour and lightness.
Accumulating Evidence for Axonal Translation in Neuronal Homeostasis

The specialized structure of the neuron requires that homeostasis is sustained over the meter or more that may separate a cell body from its axonal terminus. Given this impressive distance and an axonal volume that is many times that of the cell body, how is such a compartment grown during development, re-grown after injury, and maintained throughout adulthood? While early answers to these questions focused on the local environment or the cell soma as supplying the needs of the axon, it is now well-established that the axon has some unique needs that can only be met from within. Decades of research have revealed local translation as an indispensable mechanism of axonal homeostasis during development and regeneration in both invertebrates and vertebrates. In contrast, the extent to which the adult, mammalian axonal proteome is maintained through local translation remains unclear and controversial. This mini-review aims to highlight important experiments that have helped to shape the field of axonal translation, to discuss conceptual arguments and recent evidence that supports local translation as important to the maintenance of adult axons, and to suggest experimental approaches that have the potential to further illuminate the role of axonal translation in neuronal homeostasis.
The Development of Specialist Industry Knowledge in Government Auditing

Government auditors play an important role in overseeing public agencies, yet there is little understanding of the types of knowledge that specialist industry auditors require in this environment and how this knowledge is acquired. This study develops a portfolio of knowledge items that various sources have suggested are important for industry-specialist auditors. It was found that the items perceived to be of greatest importance to government auditors were contained under the broad knowledge categories of “accounting”, “auditing”, and “entity-specific factors”. Most of the specialised knowledge is acquired on the job, although some of this knowledge may be better acquired through formal training.
Extending timber rotations: carbon and cost implications

A number of studies have suggested that incentives for carbon sequestration could lead to longer rotation periods for even-aged managed forests. In this article we examine the potential costs and quantity of sequestered carbon from extending rotation ages in softwood forests of the southern and western USA. A model of optimal rotations when carbon is a valued asset was developed to show how optimal rotations adjust when carbon is priced. Data on 324 types and site classes of softwood forests in southern and western states of the USA were used to examine the costs of extending rotations. The results were then aggregated by applying the marginal cost curves to inventory data within each county in these states. The results indicate that in these 12 states, about 15 million tCO2 could be sequestered for less than $7/tCO2 (1 tCO2 = 1,000 kg CO2), although for substantially higher carbon prices of $55/tCO2, up to 209 million tCO2 could be sequestered. Timber prices were found to have an important influence on the marginal costs of carbon sequestration, with site quality being of secondary importance. The results also showed that at $55/tCO2 potentially 1 million ha of softwood forests could be set aside, mostly in the western states.
Feasibility of Currency Unions in Asia - An Assessment Using Generalized Purchasing Power Parity -

This paper examined the economic feasibility of forming a regional currency block in Asia, by adopting a generalized purchasing power parity (G-PPP) approach to identify the existence of common trends in real exchange rates among a group of countries. To be specific, we conducted both bilateral and multilateral co-integration estimation on real exchange rates with the samples of 17 Asian countries covering south Asia during the post- 1997-98 crisis period. Our findings are as follows; First, Japan, China and Korea are shown to be little candidate for any optimum currency areas. Second, ASEAN and south Asia, as a group, passed the G-PPP condition. Third, some co-integrating interactions were interestingly found between ASEAN and south Asian members. Our strategic implication emphasizes on the significance of a smaller local subgroup multi-speed strategy toward a long-run goal of currency union in Asia.
Relationships: The real challenge of corporate global citizenship

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