Miracle-dz/UniFAR-FTUs huggingface dataset:
Home assessment of peak inspiratory flow through the Turbohaler in asthmatic patients.

BACKGROUND: The efficacy of dry powder inhalers depends on the patient's inspiratory flow. Drug delivery from the Turbohaler (Turbuhaler in some countries), a multidose powder inhaler, is optimal at flows of > 40 l/min. The aim of this study was to investigate the peak inspiratory flow that can be generated by asthmatic patients through the budesonide Turbohaler (PIFTBH) during maintenance treatment at home. METHODS: Thirty asthmatic patients, consecutively recruited from the outpatient clinic, inhaled their maintenance dose of 800 (n = 16) or 1600 micrograms/day (n = 14) for two months or one month, respectively. The Turbohaler was connected to a modified Vitalograph Compact installed at home to obtain printed PIFTBH values for all inhalations. Peak expiratory flow (PEF) was measured twice daily. RESULTS: Flows were remarkably constant with individual mean PIFTBH values ranging from 55 l/min to 95 l/min. Only 13 of the 5248 PIFTBH recordings taken at home (three patients) were < 40 l/min and all were > 30 l/min. Weekly mean morning PEF values ranged from 114 l/min to 733 l/min. PIFTBH values could not be accurately predicted from lung function parameters in individual patients. CONCLUSIONS: In a group of stable asthmatic patients inspiratory flow rates rarely fell below the 40 l/min needed to operate a Turbohaler.
Providing adaptive QoS to layered video over wireless local area networks through real-time retry limit adaptation

Robust streaming of video over 802.11 wireless LANs (WLANs) poses many challenges, including coping with packets losses caused by network buffer overflow or link erasures. In this paper, we propose a novel error protection method that can provide adaptive quality-of-service (QoS) to layered coded video by utilizing priority queueing at the network layer and retry-limit adaptation at the link layer. The design of our method is motivated by the observation that the retry limit settings of the MAC layer can be optimized in such a way that the overall packet losses that are caused by either link erasure or buffer overflow are minimized. We developed a real-time retry limit adaptation algorithm to trace the optimal retry limit for both the single-queue (or single-layer) and multiqueue (or multilayer) cases. The video layers are unequally protected over the wireless link by the MAC with different retry limits. In our proposed transmission framework, these retry limits are dynamically adapted depending on the wireless channel conditions and traffic characteristics. Furthermore, the proposed priority queueing discipline is enhanced with packet filtering and purging functionalities that can significantly save bandwidth by discarding obsolete or un-decodable packets from the buffer. Simulations show that the proposed cross-layer protection mechanism can significantly improve the received video quality.
Global microRNA profiles in cervical squamous cell carcinoma depend on Drosha expression levels

Gain of chromosome 5p is seen in over 50% of advanced cervical squamous cell carcinomas (SCCs), although the genes responsible for the selective advantage provided by this abnormality are poorly understood. In the W12 cervical carcinogenesis model, we observed that 5p gain was rapidly selected over ∼15 population doublings and was associated with the acquisition of a growth advantage and invasiveness. The most significantly upregulated transcript following 5p gain was the microRNA (miRNA) processor Drosha. In clinically progressed cervical SCC, Drosha copy‐number gain was seen in 21/36 clinical samples and 8/10 cell lines and there was a significant association between Drosha transcript levels and copy‐number gain. Other genes in the miRNA processing pathway, DGCR8, XPO5 and Dicer, showed infrequent copy‐number gain and over‐expression. Drosha copy‐number and expression were not elevated in pre‐malignant cervical squamous intraepithelial lesions. Importantly, global miRNA profiling showed that Drosha over‐expression in cervical SCC appears to be of functional significance. Unsupervised principal component analysis of a mixed panel of cervical SCC cell lines and clinical specimens showed clear separation according to Drosha over‐expression. miRNAs most significantly associated with Drosha over‐expression are implicated in carcinogenesis in other tissues, suggesting that they regulate fundamental processes in neoplastic progression. Our evidence suggests that copy‐number driven over‐expression of Drosha and consequent changes in miRNAs are likely to be important contributors to the selective advantage provided by 5p gain in cervical neoplastic progression. Copyright © 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The Rise and Fall of Regional Inequalities

This paper analyses how the degree of regional integration affects regional differences in production structures and income levels. With high transport costs, industry is spead across regions to meet final consumer demad. As transport costs fall, increasing returns interacting with labour mobility and/or inout-output linkages between firms create a tendency for the agglomeration of increasing returns activities. When workers migrate towards locations with more firms and higher real wages, this intensifies agglomeration. When instead workers do not move across regions, further reductions in transport costs make firms increasingly sensitive to wage differentials, leading industry to spread out again.
Unpopular, Overweight, and Socially Inept: Reconsidering the Stereotype of Online Gamers

Online gaming has become an activity associated with a highly specific, caricatured, and often negative image. This "stereotype" has permeated the collective consciousness, as online gamers have become common caricatures in popular media. A lack of comprehensive demographic inquiries into the online gaming population has made it difficult to dispute these stereotypical characteristics and led to rising concerns about the validity of these stereotypes. The current study aims to clarify the basis of these negative characterizations, and determine whether online video game players display the social, physical, and psychological shortcomings stereotypically attributed them. Sampling and recruiting was conducted using a two-stage approach. First, a representative sample of 50,000 individuals aged 14 and older who were asked about their gaming behavior in an omnibus telephone survey. From this sample, 4,500 video game players were called for a second telephone interview, from which the current data were collected. Only those participants who completed all of the questions relating to video game play were retained for the current analysis (n=2,550). Between- and within-group analyses were enlisted to uncover differences between online, offline, and nongame playing communities across varying degrees of involvement. The results indicate that the stereotype of online gamers is not fully supported empirically. However, a majority of the stereotypical attributes was found to hold a stronger relationship with more involved online players than video game players as a whole, indicating an empirical foundation for the unique stereotypes that have emerged for this particular subgroup of video game players.
Effect of longitudinal laser mode beating in damage probability measurements

In this study influence of temporal effects are investigated within a context of laser-induced damage threshold (LIDT) measurements. 1-on-1 LIDT testing has been performed with laser operating in single- and multilongitudinal mode regimes. Four fused silica samples were chosen for investigation. Qualitative differences in the damage morphology and damage probability curve have been observed. Analysis of these phenomena was performed by employing Monte Carlo simulations representing the statistical interaction between laser irradiation and randomly distributed damage precursors. The results and findings of this study are reported and discussed in detail.
Linear-time smoke animation with vortex sheet meshes

We present the first quality physics-based smoke animation method which runs in time approximately linear in the size of the rendered two-dimensional visual detail. Our fundamental representation is a closed triangle mesh surface dividing space between clear air and a uniformly smoky region, on which we compute vortex sheet dynamics to accurately solve inviscid buoyant flow. We handle arbitrary moving no-stick solid boundaries and by default handle an infinite domain. The simulation itself runs in time linear to the number of triangles thanks to the use of a well-conditioned integral equation treatment together with a Fast Multipole Method for linear-time summations, providing excellent performance. Basic zero-albedo smoke rendering, with embedded solids, is easy to implement for interactive rates, and the mesh output can also serve as an extremely compact and detailed input to more sophisticated volume rendering.
Global localization using distinctive visual features

We have previously developed a mobile robot system which uses scale invariant visual landmarks to localize and simultaneously build a 3D map of the environment In this paper, we look at global localization, also known as the kidnapped robot problem, where the robot localizes itself globally, without any prior location estimate. This is achieved by matching distinctive landmarks in the current frame to a database map. A Hough transform approach and a random sample consensus (RANSAC) approach for global localization are compared, showing that RANSAC is much more efficient. Moreover, robust global localization can be achieved by matching a small sub-map of the local region built from multiple frames.
Bioeconomic perspectives to an optimal control dengue model

A model with six mutually exclusive compartments related to dengue is studied. Three vector control tools are considered: insecticides (larvicide and adulticide) and mechanical control. The basic reproduction number associated to the model is presented. The problem is studied using an optimal control approach. The human data are based on the dengue outbreak that occurred in Cape Verde. Control measures are simulated in different scenarios and their consequences analysed.
Novel hybrid intrusion detection system for clustered wireless sensor network

Wireless sensor network (WSN) is regularly deployed in unattended and hostile environments. The WSN is vulnerable to security threats and susceptible to physical capture. Thus, it is necessary to use effective mechanisms to protect the network. It is widely known, that the intrusion detection is one of the most efficient security mechanisms to protect the network against malicious attacks or unauthorized access. In this paper, we propose a hybrid intrusion detection system for clustered WSN. Our intrusion framework uses a combination between the Anomaly Detection based on support vector machine (SVM) and the Misuse Detection. Experiments results show that most of routing attacks can be detected with low false alarm.
Nasal sound production in echolocating delphinids (Tursiops truncatus and Pseudorca crassidens) is dynamic, but unilateral: clicking on the right side and whistling on the left side

SUMMARY Toothed whales produce sound in their nasal complex by pneumatic actuation of phonic lip pairs within the blowhole. It has been hypothesized that dual actuation of the phonic lip pairs can generate two pulses that merge to form a single echolocation click with a higher source level, broader bandwidth and larger potential for beam steering than if produced by a single pair of phonic lips. Here, we test that hypothesis by measuring the sound production of five echolocating delphinids using hydrophones around the animals and imbedded in on-animal suction cups. We show that the studied animals click with their right pair of phonic lips and whistle with their left pair. We demonstrate that, with just a single pair of phonic lips, they can change the click energy levels over five orders of magnitude, change the click centroid frequencies over more than two octaves, and modulate the sound radiation from the melon for beam steering. We conclude that all of the click dynamics ascribed to dual actuation of two phonic lip pairs can be achieved with actuation of just the right pair of phonic lips, and we propose that the large dynamic range of source outputs is achieved by highly controlled modulation of the pneumatic driving pressure, the tension of the phonic lip labia and the conformation of the fatty melon and associated air sacs.
Impact of Selective Mapping Strategies on Automated Laboratory Result Notification to Public Health Authorities

Automated electronic laboratory reporting (ELR) for public health has many potential advantages, but requires mapping local laboratory test codes to a standard vocabulary such as LOINC. Mapping only the most frequently reported tests provides one way to prioritize the effort and mitigate the resource burden. We evaluated the implications of selective mapping on ELR for public health by comparing reportable conditions from an operational ELR system with the codes in the LOINC Top 2000. Laboratory result codes in the LOINC Top 2000 accounted for 65.3% of the reportable condition volume. However, by also including the 129 most frequent LOINC codes that identified reportable conditions in our system but were not present in the LOINC Top 2000, this set would cover 98% of the reportable condition volume. Our study highlights the ways that our approach to implementing vocabulary standards impacts secondary data uses such as public health reporting.
A stochastic model of grain size distribution during dynamic recrystallization

Abstract The grain size distribution (GSD) during dynamic recrystallization was investigated by a simple nucleation-and-growth model. The steady-state GSD is represented by a sum of a series of lognormal distributions, and is characterized by an asymmetric bell-shaped curve in a logarithmic frequency diagram. The distributions of one- and two-dimensional grain size (i.e. length of linear intercept and diameter of intersection area, respectively) are similar to those of the lognormal distribution. The average grain size varies with the ratio of nucleation rate and growth rate, but is hardly affected by the size of nuclei.
Interval Based Relaxation Heuristics for Numeric Planning with Action Costs

We adapt the relaxation heuristics hmax, hadd and hFF to interval based numeric relaxation frameworks, combining them with two different relaxation techniques and with two different search techniques. In contrast to previous approaches, the heuristics presented here are not limited to a subset of numeric planning and support action costs.
The influence of photoperiod and temperature on the induction of diapause in Diataraxia oleracea L. (Lepidoptera).

The induction of diapause in the pupa of Diataraxia oleracea is influenced by temperature and photoperiod during the larval stage. Low temperatures and short photoperiods tend to induce diapause while high temperatures and long photoperiods tend to prevent diapause. Diapause is not influenced by light intensity during the larval stage providing the intensity is above a certain minimum. Diapause is prevented at high temperatures (30-34° C.) if the larvae are reared in darkness. The photoperiod is operative as a factor influencing diapause only between the beginning of the moulting sleep prior to ecdysis to the last instar and the 3rd-5th day of the last instar. A single diapause-preventing photo-period during the moulting sleep is probably sufficient to prevent diapause. Diapause in D. oleracea is not influenced by photoperiodically controlled substances in the larval food plant.
Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma.

RATIONALE One-quarter to one-third of individuals with asthma smoke, which may affect response to therapy and contribute to poor asthma control. OBJECTIVES To determine if the response to an inhaled corticosteroid or a leukotriene receptor antagonist is attenuated in individuals with asthma who smoke. METHODS In a multicenter, placebo-controlled, double-blind, double-dummy, crossover trial, 44 nonsmokers and 39 light smokers with mild asthma were assigned randomly to treatment twice daily with inhaled beclomethasone and once daily with oral montelukast. MEASUREMENTS AND MAIN RESULTS Primary outcome was change in prebronchodilator FEV(1) in smokers versus nonsmokers. Secondary outcomes included peak flow, PC(20) methacholine, symptoms, quality of life, and markers of airway inflammation. Despite similar FEV(1), bronchodilator response, and sensitivity to methacholine at baseline, subjects with asthma who smoked had significantly more symptoms, worse quality of life, and lower daily peak flow than nonsmokers. Adherence to therapy did not differ significantly between smokers and nonsmokers, or between treatment arms. Beclomethasone significantly reduced sputum eosinophils and eosinophil cationic protein (ECP) in both smokers and nonsmokers, but increased FEV(1) (170 ml, p = 0.0003) only in nonsmokers. Montelukast significantly increased a.m. peak flow in smokers (12.6 L/min, p = 0.002), but not in nonsmokers. CONCLUSIONS In subjects with mild asthma who smoke, the response to inhaled corticosteroids is attenuated, suggesting that adjustments to standard therapy may be required to attain asthma control. The greater improvement seen in some outcomes in smokers treated with montelukast suggests that leukotrienes may be important in this setting. Larger prospective studies are required to determine whether leukotriene modifiers can be recommended for managing asthma in patients who smoke.
Prophylactic catheter ablation for the prevention of defibrillator therapy.

BACKGROUND For patients who have a ventricular tachyarrhythmic event, implantable cardioverter-defibrillators (ICDs) are a mainstay of therapy to prevent sudden death. However, ICD shocks are painful, can result in clinical depression, and do not offer complete protection against death from arrhythmia. We designed this randomized trial to examine whether prophylactic radiofrequency catheter ablation of arrhythmogenic ventricular tissue would reduce the incidence of ICD therapy. METHODS Eligible patients with a history of a myocardial infarction underwent defibrillator implantation for spontaneous ventricular tachycardia or fibrillation. The patients did not receive antiarrhythmic drugs. Patients were randomly assigned to defibrillator implantation alone or defibrillator implantation with adjunctive catheter ablation (64 patients in each group). Ablation was performed with the use of a substrate-based approach in which the myocardial scar is mapped and ablated while the heart remains predominantly in sinus rhythm. The primary end point was survival free from any appropriate ICD therapy. RESULTS The mortality rate 30 days after ablation was zero, and there were no significant changes in ventricular function or functional class during the mean (+/-SD) follow-up period of 22.5+/-5.5 months. Twenty-one patients assigned to defibrillator implantation alone (33%) and eight patients assigned to defibrillator implantation plus ablation (12%) received appropriate ICD therapy (antitachycardia pacing or shocks) (hazard ratio in the ablation group, 0.35; 95% confidence interval, 0.15 to 0.78, P=0.007). Among these patients, 20 in the control group (31%) and 6 in the ablation group (9%) received shocks (P=0.003). Mortality was not increased in the group assigned to ablation as compared with the control group (9% vs. 17%, P=0.29). CONCLUSIONS In this randomized trial, prophylactic substrate-based catheter ablation reduced the incidence of ICD therapy in patients with a history of myocardial infarction who received ICDs for the secondary prevention of sudden death. (Current Controlled Trials number, ISRCTN62488166 [controlled-trials.com].).
Molecular Basis for Cyclooxygenase Inhibition by the Non-steroidal Anti-inflammatory Drug Naproxen*

Naproxen ((S)-6-methoxy-α-methyl-2-naphthaleneacetic acid) is a powerful non-selective non-steroidal anti-inflammatory drug that is extensively used as a prescription and over-the-counter medication. Naproxen exhibits gastrointestinal toxicity, but its cardiovascular toxicity may be reduced compared with other drugs in its class. Despite the fact that naproxen has been marketed for many years, the molecular basis of its interaction with cyclooxygenase (COX) enzymes is unknown. We performed a detailed study of naproxen-COX-2 interactions using site-directed mutagenesis, structure-activity analysis, and x-ray crystallography. The results indicate that each of the pendant groups of the naphthyl scaffold are essential for COX inhibition, and only minimal substitutions are tolerated. Mutation of Trp-387 to Phe significantly reduced inhibition by naproxen, a result that appears unique to this inhibitor. Substitution of S or CH2 for the O atom of the p-methoxy group yielded analogs that were not affected by the W387F substitution and that exhibited increased COX-2 selectivity relative to naproxen. Crystallization and x-ray analysis yielded structures of COX-2 complexed to naproxen and its methylthio analog at 1.7 and 2.3 Å resolution, respectively. The combination of mutagenesis, structure analysis, and x-ray crystallography provided comprehensive information on the unique interactions responsible for naproxen binding to COX-2.
The role of animal nutrition in improving the nutritive value of animal-derived foods in relation to chronic disease

Foods derived from animals are an important source of nutrients in the diet; for example, milk and meat together provide about 60 and 55% of the dietary intake of Ca and protein respectively in the UK. However, certain aspects of some animal-derived foods, particularly their fat and saturated fatty acid (SFA) contents, have led to concerns that these foods substantially contribute to the risk of CVD, the metabolic syndrome and other chronic diseases. In most parts of Europe dairy products are the greatest single dietary source of SFA. The fatty acid composition of various animal-derived foods is, however, not constant and can, in many cases, be enhanced by animal nutrition. In particular, milk fat with reduced concentrations of the C12–16 SFA and an increased concentration of 18:1 MUFA is achievable, although enrichment with very-long-chain n-3 PUFA is much less efficient. However, there is now evidence that some animal-derived foods (notably milk products) contain compounds that may actively promote long-term health, and research is urgently required to fully characterise the benefits associated with the consumption of these compounds and to understand how the levels in natural foods can be enhanced. It is also vital that the beneficial effects are not inadvertently destroyed in the process of reducing the concentrations of SFA. In the future the role of animal nutrition in creating foods closer to the optimum composition for long-term human health is likely to become increasingly important, but production of such foods on a scale that will substantially affect national diets will require political and financial incentives and great changes in the animal production industry.