Miracle-dz/UniFAR-FTUs huggingface dataset:
Ethylene Activates the EIN2-EIN3/EIL1 Signaling Pathway in Tapetum and Disturbs Anther Development in Arabidopsis

Ethylene was previously reported to repress stamen development in both cucumber and Arabidopsis. Here, we performed a detailed analysis of the effect of ethylene on anther development. After ethylene treatment, stamens but not pistils display obvious developmental defects which lead to sterility. Both tapetum and microspores (or microsporocytes) degenerated after ethylene treatment. In ein2-1 and ein3-1 eil1-1 mutants, ethylene treatment did not affect their fertility, indicating the effects of ethylene on anther development are mediated by EIN2 and EIN3/EIL1 in vivo. The transcription of EIN2 and EIN3 are activated by ethylene in the tapetum layer. However, ectopic expression of EIN3 in tapetum did not induce significant anther defects, implying that the expression of EIN3 are regulated post transcriptional level. Consistently, ethylene treatment induced the accumulation of EIN3 in the tapetal cells. Thus, ethylene not only activates the transcription of EIN2 and EIN3, but also stabilizes of EIN3 in the tapetum to disturb its development. The expression of several ethylene related genes was significantly increased, and the expression of the five key transcription factors required for tapetum development was decreased after ethylene treatment. Our results thus point out that ethylene inhibits anther development through the EIN2-EIN3/EIL1 signaling pathway. The activation of this signaling pathway in anther wall, especially in the tapetum, induces the degeneration of the tapetum and leads to pollen abortion.
Is PSR J0250+5854 at the Hall Attractor Stage?

In this note we propose that recently discovered radio pulsar J0250+5854 with 23.5 sec spin period is presently at the Hall attractor stage. This can explain low temperature and absence of magnetar-like activity of this source together with its spin period and period derivative. We present results of calculations of the evolution of this source in a simple model of magnetic field decay. The neutron star could start its evolution as a magnetar with initial field $\sim 10^{14}-10^{15}$ G for realistic range of parameter $Q$ describing crust imperfections. Future measurements of surface temperature and age of this neutron star might help to probe this hypothesis.
Evidence Gaps in Clinical Trials of Pharmacologic Treatment for H1-Antihistamine-Refractory Chronic Spontaneous Urticaria: A Systematic Review and Future Perspectives

No data addressing issues concerning disparities in participant and trial characteristics and trial outcome reporting have been established in clinical trials for H1-antihistamine-refractory chronic spontaneous urticaria (CSU). To better harmonize and compare the different treatment interventions, we systematically evaluated the overall landscape of pharmacological treatments for H1-antihistamine-refractory CSU clinical trials published between 2000 and 2021. This systematic review included 23 randomized clinical trials involving 2480 participants from 22 countries. We found significant increases in the number of globally published and newly tested drugs, especially biologic drugs. Regarding relatively small trials, we found that people living with H1-antihistamine-refractory CSU who were identified as members of minority groups (non-white population), populations of regions other than North America/Europe, and populations of low- to lower/upper-middle-income countries are underrepresented. Most trials were designed to evaluate treatment efficacy and safety profiles; however, less than half of the included trials reported the patient’s perspective in terms of patient-reported outcomes. Disparities in outcome reporting, including clinimetric tools for assessing treatment response and outcome sets, were observed. To close the evidence gap in H1-antihistamine-refractory CSU trials, strategies for improving trial and participant enrollment and standardizing core outcome sets for trial reporting are needed.
Therapeutic Application of an Ag-Nanoparticle-PNIPAAm-Modified Eggshell Membrane Construct for Dermal Regeneration and Reconstruction

Current therapeutic treatments for the repair and/or replacement of damaged skin following disease or traumatic injury is severely limited. The chicken eggshell membrane (ESM) is a unique material: its innate physical and mechanical characteristics offer optimal barrier properties and, as a naturally derived extract, it demonstrates inherent biocompatibility/biodegradability. To further enhance its therapeutic and clinical potential, the ESM can be modified with the thermo-responsive polymer, poly(N-isopropylacrylAmide) (PNIPAAm) as well as the incorporation of (drug-loaded) silver nanoparticles (AgNP); essentially, by a simple change in temperature, the release and delivery of the NP can be targeted and controlled. In this study, ESM samples were isolated using a decellularization protocol, and the physical and mechanical characteristics were profiled using SEM, FT-IR, DSC and DMA. PNIPAAm was successfully grafted to the ESM via amidation reactions and confirmed using FT-IR, which demonstrated the distinctive peaks associated with Amide A (3275 cm−1), Amide B (2970 cm−1), Amide I (1630 cm−1), Amide II (1535 cm−1), CH2, CH3 groups, and Amide III (1250 cm−1) peaks. Confirmation of the incorporation of AgNP onto the stratified membrane was confirmed visually with SEM, qualitatively using FT-IR and also via changes in absorbance at 380 nm using UV-Vis spectrophotometry during a controlled release study for 72 h. The biocompatibility and cytotoxicity of the novel constructs were assessed using human dermal fibroblast (HDFa) and mouse dermal fibroblast (L929) cells and standard cell culture assays. Metabolic activity assessment (i.e., MTS assay), LDH-release profiles and Live/Dead staining demonstrated good attachment and spreading to the samples, and high cell viability following 3 days of culture. Interestingly, longer-term viability (>5 days), the ESM-PNIPAAm and ESM-PNIPAAm (AgNP) samples showed a greater and sustained cell viability profile. In summary, the modified and enhanced ESM constructs were successfully prepared and characterized in terms of their physical and mechanical profiles. AgNP were successfully loaded into the construct and demonstrated a desirable release profile dependent on temperature modulation. Fibroblasts cultured on the extracted ESM samples and ESM-PNIPAAm demonstrated high biocompatibility in terms of high cell attachment, spreading, viability and proliferation rates. As such, this work summarizes the development of an enhanced ESM-based construct which may be exploited as a clinical/therapeutic wound dressing as well as a possible application as a novel biomaterial scaffold for drug development.
Study on Risk Factors Related to Intrauterine Adhesion Based on Meta-Analysis

Objective Intrauterine adhesion (IUA) is a severe complication that occurs following abortion. To evaluate the related risk factors of uterine cavity adhesion by meta-analysis. Methods The research literature on the influencing factors of patients with intrauterine adhesions published from January 2010 to December 2020 in PubMed, EMBASE, Cochrane Library, web of science, CNKI, Wanfang Data, VIP, and CBM were retrieved by computer. Two evaluators independently screened the literature, extracted the data, and evaluated the treatment according to the inclusion and exclusion criteria and then analyzed it with revman5.3 software. Results Finally, 12 literatures were included, with a total sample size of 2341 cases. The results of meta-analysis showed that pelvic inflammation (p = 0.05), negative pressure during uterine suction (p < 0.0001), and uterine suction time (p < 0.00001) were the risk factors for uterine cavity adhesion. The combined or and 95% CI of each factor were 2.05 (1.24, 3.38), 125.61 (67.35, 183.87), and 4.52 (4.21, 4.84), respectively. However, the number of pregnancies, the number of curettages, the average number of births, abortion, myomectomy, menstrual abnormalities, and infertility have little impact on the occurrence of intrauterine adhesions (p > 0.05). Conclusion Pelvic inflammatory disease, negative pressure during uterine suction and uterine suction time are the risk factors leading to uterine cavity adhesion.
Security Analysis of a Privacy-Preserving Identity-Based Encryption Architecture

Identity-Based Encryption (IBE) has seen limited adoption, largely due to the absolute trust that must be placed in the private key generator (PKG)—an authority that computes the private keys for all the users in the environment. Several constructions have been proposed to reduce the trust required in the PKG (and thus preserve the privacy of users), but these have generally relied on unrealistic assumptions regarding non-collusion between various entities in the system. Unfortunately, these constructions have not significantly improved IBE adoption rates in real-world environments. In this paper, we present a construction that reduces trust in the PKG without unrealistic non-collusion assumptions. We achieve this by incorporating a novel combination of digital credential technology and bilinear maps, and making use of multiple random-ly-chosen entities to complete certain tasks. The main result and primary contri-bution of this paper are a thorough security analysis of this proposed construction, examining the various entity types, attacker models, and collusion oppor-tunities in this environment. We show that this construction can prevent, or at least mitigate, all considered attacks. We conclude that our construction ap-pears to be effective in preserving user privacy and we hope that this construction and its security analysis will encourage greater use of IBE in real-world environments.
SPECTRAL ENERGY DISTRIBUTIONS OF LOW-LUMINOSITY RADIO GALAXIES AT z ∼1–3: A HIGH-z VIEW OF THE HOST/AGN CONNECTION

We study the spectral energy distributions, SEDs (from FUV to MIR bands), of the first sizeable sample of 34 low-luminosity radio galaxies at high redshifts, selected in the COSMOS field. To model the SEDs, we use two different template-fitting techniques: (1) the Hyperz code that only considers single stellar templates and (2) our own developed technique 2SPD that also includes the contribution from a young stellar population and dust emission. The resulting photometric redshifts range from z ∼ 0.7 to 3 and are in substantial agreement with measurements from earlier work, but significantly more accurate. The SED of most objects is consistent with a dominant contribution from an old stellar population with an age ∼1–3 × 109 years. The inferred total stellar mass range is ∼1010–1012 M☉. Dust emission is needed to account for the 24 μm emission in 15 objects. Estimates of the dust luminosity yield values in the range Ldust ∼ 1043.5–1045.5 erg s−1. The global dust temperature, crudely estimated for the sources with an MIR excess, is ∼300–850 K. A UV excess is often observed with a luminosity in the range ∼1042–1044 erg s−1 at 2000 Å rest frame. Our results show that the hosts of these high-z low-luminosity radio sources are old massive galaxies, similar to the local FR Is. However, the UV and MIR excesses indicate the possible significant contribution from star formation and/or nuclear activity in such bands, not seen in low-z FR Is. Our sources display a wide variety of properties: from possible quasars at the highest luminosities to low-luminosity old galaxies.
CHROMOSPHERIC AND CORONAL OBSERVATIONS OF SOLAR FLARES WITH THE HELIOSEISMIC AND MAGNETIC IMAGER

We report observations of white-light ejecta in the low corona, for two X-class flares on 2013 May 13, using data from the Helioseismic and Magnetic Imager (HMI) of the Solar Dynamics Observatory. At least two distinct kinds of sources appeared (chromospheric and coronal), in the early and later phases of flare development, in addition to the white-light footpoint sources commonly observed in the lower atmosphere. The gradual emissions have a clear identification with the classical loop-prominence system, but are brighter than expected and possibly seen here in the continuum rather than line emission. We find the HMI flux exceeds the radio/X-ray interpolation of the bremsstrahlung produced in the flare soft X-ray sources by at least one order of magnitude. This implies the participation of cooler sources that can produce free-bound continua and possibly line emission detectable by HMI. One of the early sources dynamically resembles “coronal rain”, appearing at a maximum apparent height and moving toward the photosphere at an apparent constant projected speed of 134 ± 8 km s−1. Not much literature exists on the detection of optical continuum sources above the limb of the Sun by non-coronagraphic instruments and these observations have potential implications for our basic understanding of flare development, since visible observations can in principle provide high spatial and temporal resolution.
EXTERNAL COMPTON EMISSION IN BLAZARS OF NONLINEAR SYNCHROTRON SELF-COMPTON-COOLED ELECTRONS

The origin of the high-energy component in spectral energy distributions (SEDs) of blazars is still something of a mystery. While BL Lac objects can be successfully modeled within the one-zone synchrotron self-Compton (SSC) scenario, the SED of low-peaked flat spectrum radio quasars is more difficult to reproduce. Their high-energy component needs the abundance of strong external photon sources, giving rise to stronger cooling via the inverse Compton (IC) channel, and thus to a powerful component in the SED. Recently, we have been able to show that such a powerful inverse Compton component can also be achieved within the SSC framework. This, however, is only possible if the electrons cool by SSC, which results in a nonlinear process, since the cooling depends on an energy integral over the electrons. In this paper, we aim to compare the nonlinear SSC framework with the external Compton (EC) output by calculating analytically the EC component with the underlying electron distribution being either linearly or nonlinearly cooled. Due to the additional linear cooling of the electrons with the external photons, higher number densities of electrons are required to achieve nonlinear cooling, resulting in more powerful IC components. If the electrons initially cool nonlinearly, the resulting SED can exhibit a dominant SSC over the EC component. However, this dominance depends strongly on the input parameters. We conclude that, with the correct time-dependent treatment, the SSC component should be taken into account in modeling blazar flares.
SUPERMASSIVE BLACK HOLES WITH HIGH ACCRETION RATES IN ACTIVE GALACTIC NUCLEI. II. THE MOST LUMINOUS STANDARD CANDLES IN THE UNIVERSE

This is the second in a series of papers reporting on a large reverberation mapping (RM) campaign to measure black hole (BH) mass in high accretion rate active galactic nuclei (AGNs). The goal is to identify super-Eddington accreting massive black holes (SEAMBHs) and to use their unique properties to construct a new method for measuring cosmological distances. Based on theoretical models, the saturated bolometric luminosity of such sources is proportional to the BH mass, which can be used to obtain their distance. Here we report on five new RM measurements and show that in four of the cases, we can measure the BH mass and three of these sources are SEAMBHs. Together with the three sources from our earlier work, we now have six new sources of this type. We use a novel method based on a minimal radiation efficiency to identify nine additional SEAMBHs from earlier RM-based mass measurements. We use a Bayesian analysis to determine the parameters of the new distance expression and the method uncertainties from the observed properties of the objects in the sample. The ratio of the newly measured distances to the standard cosmological ones has a mean scatter of 0.14 dex, indicating that SEAMBHs can be use as cosmological distance probes. With their high luminosity, long period of activity, and large numbers at high redshifts, SEAMBHs have a potential to extend the cosmic distance ladder beyond the range now explored by Type Ia supernovae.
Extreme wave statistics in co-propagating windsea and swell

We investigate how the extreme wave statistics of a windsea is modified by a following swell, by means of laboratory experiments and simulations using a High Order Spectral Method (HOSM) of long-crested sea. The windsea spectrum is kept equal for all cases, while the swell is altered. Analysis of the combined wave system gives the impression that the mixed sea has milder extreme wave statistics than the windsea alone, especially when the nonlinearities in the two systems clearly differ. Upon partitioning the mixed sea into windsea and swell, the windsea part is found to be nearly unaffected by the swell and to be governed by essentially the same statistics irrespective of a swell being present or not. This result is found for skewness, kurtosis and exceedance probability of envelope and crest height.
An ethnographic study of visual impairments for voice user interface design

Design for Voice User Interfaces (VUIs) has become more relevant in recent years due to the enormous advances of speech technologies and their growing presence in our everyday lives. Although modern VUIs still present interaction issues, reports indicate they are being adopted by people with different disabilities and having a positive impact. For the first author's PhD research project, an ethnographic study is currently being carried out in a local charity that provides support and services to people with visual impairments. The purpose is to understand people's competencies and practices, and how these are, or could be, related to voice technologies (assistive technology and mainstream VUIs). Through direct observation and contextual interviews, we aim to investigate the problems and solutions they encounter and the ways they cope with particular situations.
Co-annihilating Dark Matter: Effective Operator Analysis and Collider Phenomenology

We study dark matter (DM) models in which there are two dark sector particles, $\chi_1$ and $\chi_2$, of near mass. In such models, co-annihilation of $\chi_1$ and $\chi_2$ may be the dominant process controlling the DM relic density during freezeout in the early universe. In this scenario, there is no significant contribution to direct and indirect detection signals, unless there exists an extreme degeneracy in the masses of the lightest dark sector particles. Therefore, relic density constraints and collider searches provide the most relevant information about these models. We consider Dirac fermion dark matter which couples to standard model (SM) particles via an effective operator. For the collider phenomenology, where an effective field theory may not be valid, we adopt a simple Z' model to provide an appropriate UV completion. We explore the interesting LHC signals that arise from the dark matter production process $pp \rightarrow \overline{\chi_1} + \chi_2 + \textrm{ jet}$, followed by the decay $\chi_2 \rightarrow \chi_1 + SM$.
Analysis on the Particularity of Higher Education Subject Development under the Background of Artificial Intelligence

Subject development plays a crucial role in higher education (HE), improving student academic performance. The HE continuously requires conceptual and empirical development to deliver valuable content to the students. The subject reforms offer quality, accessibility, affordability, accountability, and equity to accomplish continual learning. The changes in higher education subjects require a continuous assessment to understand the relationship between the reform and student performance. The subject development quality is evaluated using machine learning (ML) and artificial intelligence (AI) techniques. The existing researchers use intelligent techniques to identify student academic performance. However, the exact relationship between student performance and subject changes fails to address. Therefore, higher education learning (HEL) requires improvement to manage the Higher Education Subject Development (HESD). To achieve the research goal, AdaBoost Adaptive-Bidirectional Associative Memory (AA-BAM) network is introduced in this work. The network model uses the Hebbian supervised learning (HSL) process to create the training model. The learning process has a network parameter updating procedure that reduces the total error and deviation between the academic details. In addition, the neural model uses the memory cell that stores every processing information that recalls the output patterns with maximum accuracy. The output pattern identifies the student’s academic performance, which helps to analyze the quality of the subject development in institutions. The created system ensures 98.78% accuracy, showing that subject development correlates highly with student academic performance.
Antibranes don't go black

When D-branes are inserted in flux backgrounds of opposite charge, the resulting solution has a certain singularity in the fluxes. Recently it has been argued, using numerical solutions, that for anti-D3 branes in the Klebanov-Strassler background these singularities cannot be cloaked by a horizon, which strongly suggests they are not physical. In this note we provide an analytic proof that the singularity of all codimension-three antibrane solutions (such as anti-D6 branes in massive type IIA supergravity or anti-D3 branes smeared on the T^3 of R^3xT^3 with fluxes) cannot be hidden behind a horizon, and that the charge of black branes with smooth event horizons must have the same sign as the charge of the flux background. Our result indicates that infinitesimally blackening the antibranes immediately triggers brane-flux annihilation, and strengthens the intuition that antibranes placed in flux with positive charge immediately annihilate against it.
Improving the performance of superconducting microwave resonators in magnetic fields

The operation of superconducting coplanar waveguide cavities, as used for circuit quantum electrodynamics and kinetic inductance detectors, in perpendicular magnetic fields normally leads to a reduction in the device performance due to energy dissipating Abrikosov vortices. We experimentally investigate the vortex induced energy losses in such Nbresonators with different spatial distributions of micropatterned pinning sites (antidots) by transmission spectroscopy measurements at 4.2 K. In comparison to resonators without antidots we find a significant reduction in vortex induced losses, and thus increased quality factors over a broad range of frequencies and applied powers in moderate fields.
Gyratonic p p waves and their impulsive limit

We investigate a class of gravitational $pp$ waves which represent the exterior vacuum field of spinning particles moving with the speed of light. Such exact spacetimes are described by the original Brinkmann form of the $pp$-wave metric including the often-neglected off-diagonal terms. We put emphasis on a clear physical and geometrical interpretation of these off-diagonal metric components. We explicitly analyze several new properties of these spacetimes associated with the spinning character of the source, such as rotational dragging of frames, geodesic deviation, impulsive limits and the corresponding behavior of geodesics.