Miracle-dz/UniFAR-FTUs huggingface dataset:
The handbook of narrative and psychotherapy: Practice, theory, and research.

Preface, by Lynne Angus & John McLeod PART ONE. THE 'NARRATIVE TURN': WHY STORIES MATTER IN PSYCHOTHERAPY 1. The Narrative Creation of Self, by Jerome Bruner 2. Folk Psychology & Narrative Practices, by Michael White 3. Narrative Therapy & Postmodernism, by Donald Polkinghorne PART TWO. WORKING WITH NARRATIVE IN PSYCHOTHERAPY 4. The CCRT Approach to Working with Patient Narratives in Psychodynamic Psychotherapy, by Howard Book 5. "What's the Story? " Working with Narrative in Experimental Psychotherapy, by Lynne Angus, Jennifer Lewin, Beverly Bowes-Bouffard, & Debra Rotondi-Trevisan 6. Nurturing Nature: Cognitive Narrative Strategies, by Oscar Goncalves, Margarida Henriques, & Paulo Machado 7. Working with Narrative in Psychotherapy: A Relational Constructivist Approach, by Luis Botella, Olga Herrero, Meritxell Pacheco, & Sergei Corbella 8. A Poststructuralist Approach to Narrative Work, by Gene Combs & Jill Freedman PART THREE. NARRATIVE IDENTITY & SELF-MULTIPLICITY: IMPLICATIONS FOR PSYCHOTHERAPY 9. Narrative Identity & Narrative Therapy, by Dan McAdams 10. The Innovation of Self-Narrative: A Dialogical Approach, by Hubert Hermans 11. Assimilation & Narrative: Stories as Meaning Bridges, by Katerine Osatuke, Meredith Glick, Michael Gray, D'Arcy Reynolds, Jr., Carol Humphreys, Lisa Salvi, & William Stiles 12. Minding Our Therapeutic Tales: Treatments in Perspectivism, by Robert Russell & Fred B. Bryant PART FOUR. NARRATIVE ASSESSMENT STRATEGIES IN PSYCHOTHERAPY 13. Self-defining Memories, Narrative Identity & Psychotherapy: A Conceptual Model, Empirical Investigation & Case Report, by Jefferson Singer & Pavel Blagov 14. The Narrative Assessment Interview: Assessing Self-change in Psychotherapy, by Karen Hardtke & Lynne Angus 15. Disorganized Narratives: The Psychological Condition & Its Treatment, by Giancarlo Dimaggio & Antonio Semerari 16. Story Dramaturgy & Personal Conflict: JAKOB - A Tool for Narrative Understanding & Psychotherapeutic Pratice, by Brigitte Boothe & Agnes von Wyl PART FIVE. EMERGING TRENDS & FUTURE DIRECTIONS 17. Narrative Activity: Clients' & Therapists' Intentions in the Process of Narration in Psychotherapy, by Heidi M. Levitt & David L. Rennie 18. "To Tell My Story": Configuring Interpersonal Relations with Narrative Processes, by Timothy Anderson 19. The Contributions of Emotion Processes to Narrative Change in Psychotherapy: A Dialectical Constructivist Approach, by Leslie Greenberg & Lynne Angus 20. Social Constuctionism, Narrative, & Psychotherapy, by John McLeod 21. Towards an Integrative Framework for Understanding the Role of Narrative in the Psychotherapy Process, by Lynne Angus & John McLeod
Measuring Antigen‐Specific Immune Responses, 2008 update

Overall, the last 10 years have seen an explosion in the field of antigen-specific immune response monitoring. As summarized in this issue of Cytometry and at the MASIR conferences, these technologies have provided new insights into the basic biology of the immune system and are beginning to provide useful clinical information. These papers highlight the areas that are being actively explored.
Del juicio clínico al análisis de supervivencia

Clinical research XXI. From the clinical judgment to survival analysis La toma de decisiones durante la atención médica implica el conocimiento de la evolución clínica de la enfermedad. A su vez, el conocimiento de la evolución clínica permite estimar la posibilidad de ocurrencia de un fenómeno en un tiempo determinado o su tiempo de duración. Entre los modelos estadísticos con los que es posible obtener una medida de resumen para estimar el tiempo de ocurrencia de un fenómeno en una población determinada se encuentran la regresión lineal (variable dependiente continua y con distribución normal [tiempo a la ocurrencia del fenómeno]), la regresión logística (variable dependiente dicotómica, en un solo intervalo) y las curvas de supervivencia (variable dependiente dicotómica, en múltiples intervalos). La primera referencia que se tiene sobre este tipo de análisis es el trabajo publicado en 1693 por el astrónomo, físico y matemático inglés Edmundo Halley —famoso por el cálculo de la órbita y aparición del cometa reconocido como el primer cometa periódico (el 1P/cometa Halley)— quien contribuyó en el área de la salud con la estimación de la tasa de mortalidad para una población polaca. Las curvas de supervivencia permiten calcular la probabilidad de que ocurra un fenómeno a distintos intervalos y, de igual forma, permiten estimar la mediana de supervivencia de cualquier fenómeno de interés (aunque se utiliza el término supervivencia, el desenlace no necesariamente tiene que ser muerte, sino la ocurrencia de cualquier otro fenómeno).
Contemporary Epidemiology of Renal Cell Cancer

We analyzed renal cell cancer incidence patterns in the United States and reviewed recent epidemiologic evidence with regard to environmental and host genetic determinants of renal cell cancer risk. Renal cell cancer incidence rates continued to rise among all racial/ethnic groups in the United States, across all age groups, and for all tumor sizes, with the most rapid increases for localized stage disease and small tumors. Recent cohort studies confirmed the association of smoking, excess body weight, and hypertension with an elevated risk of renal cell cancer, and suggested that these factors can be modified to reduce the risk. There is increasing evidence for an inverse association between renal cell cancer risk and physical activity and moderate intake of alcohol. Occupational exposure to trichloroethylene has been positively associated with renal cell cancer risk in several recent studies, but its link with somatic mutations of the von Hippel-Lindau gene has not been confirmed. Studies of genetic polymorphisms in relation to renal cell cancer risk have produced mixed results, but genome-wide association studies with larger sample size and a more comprehensive approach are underway. Few epidemiologic studies have evaluated risk factors by subtypes of renal cell cancer defined by somatic mutations and other tumor markers.
Professionalism Redundant, Reshaped, or Reinvigorated? Realizing the “Third Logic” in Contemporary Health Care

Recent decades have seen the influence of the professions decline. Lately, commentators have suggested a revived role for a “new” professionalism in ensuring and enhancing high-quality health care in systems dominated by market and managerial logics. The form this new professionalism might take, however, remains obscure. This article uses data from an ethnographic study of three English health care improvement projects to analyze the place, potential, and limitations of professionalism as a means of engaging clinicians in efforts to improve service quality. We found that appeals to notions of professionalism had strong support among practitioners, but converting enthusiasm for the principle of professionalism into motivation to change practice was not straightforward. Some tactics used in pursuit of this deviated sharply from traditional models of collegial social control. In systems characterized by fissures between professional groups and powerful market and managerial influences, we suggest that professionalism must interact creatively but carefully with other logics.
Success and Causality in Sport: The Influence of Perception

This study was designed to examine perceptions of causality and perceptions of success in women's intercollegiate gymnastics and to determine the relative influence of perception of success on causal explanations for performance and the reciprocal influence, if any, of causal attributions on perceptions of success. Intercollegiate gymnasts were asked to indicate how successful they felt their performance had been on each of four Olympic gymnastic events. The gymnasts also completed the Causal Dimension Scale (Russell, 1982) following performance of each event. The score awarded by the judges for each event was employed as an objective, absolute measure of performance. Multivariate analyses of variance that revealed more internal, stable, and controllable attributions for performance were made by those gymnasts who scored high and perceived their performance as more successful than those gymnasts who scored lower and perceived their performance as less successful. The results of this study are discu.
Eradication of HIV from the brain: reasons for pause.

Recent advances in HIV research have made it possible to scientists to consider approaches to eradicate HIV infection from T cell reservoirs. These include either engineering cells that would be resistant to HIV infection of suppression of HIV replication with intensified antiretroviral therapy followed by activation of HIV reservoirs and elimination of these cells by cytotoxic immune responses. Several variations of this theme are being considered. Careful consideration needs to be given to the viral reservoirs in the brain, where it may infect cell types such as macrophages, microglia and astrocytes. The life cycle of the virus in these cells is distinct compared to that in T cells and thus the antiviral approaches may not be effective in fully suppressing viral replication. Even small amounts of viral proteins produced by these cells can be neurotoxic. And if T cells in the periphery are restored before impacting the brain reservoirs these cells may enter the brain causing a T cell mediated encephalitis. This articlediscusses thefundamentalquestionsthatneedto beaddressedwithregards tothe biology of the virus in the brain before successful attempts to eradicate the virus can be made. 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins AIDS 2011, 25:000‐000
Lifespan multilingual education, a long-term investment

It is estimated that over the next decades, the number of older adults will reach record levels worldwide. With the increasing age, the prevalence of neurodegenerative diseases, such as Alzheimer’s disease, is also estimated to increase. Therefore, protecting older adults from the age-related effects of cognitive decline is one of the greatest challenges of the next following decades, since these will increase pressure on families, health and education systems, and, above all, economies on a global scale. There is a growing body of evidence emphasizing the beneficial effects of bilingualism acting as a safeguard against cognitive decline linked to the aging process. Building on this evidence, this paper reviews the latest studies which examine the effects of bilingualism on cognition in older age, and investigates whether foreign language learning at a later stage in life can constitute an optimal solution for building cognitive reserve, as it is scientifically proven that language learning engages an extensive brain network that is known to overlap with the brain regions negatively affected by the ageing process. This paper aims to highlight the importance of lifelong bilingualism and, using a different perspective, to promote lifespan multilingual education.On estime qu’au cours des prochaines décennies, le nombre de personnes âgées atteindra des niveaux records dans le monde entier. En outre on estime qu’avec l’augmentation de l’âge, la prévalence de maladies neurodégénératives, telles que la maladie d’Alzheimer, augmentera à son tour. Pour cette raison, la protection des personnes âgées contre les effets du déclin cognitif liés à l’âge est l’un des plus grands défis des prochaines décennies, puisque ces effets vont augmenter la pression sur les familles, sur les systèmes de santé et d’éducation, et, surtout, sur les économies à l’échelle mondiale. Un nombre croissant de preuves met l’accent sur les effets bénéfiques du bilinguisme agissant comme une protection contre le déclin cognitif lié au processus de vieillissement. Se basant sur cette preuve, le présent article évalue les dernières études qui examinent les effets du bilinguisme sur la connaissance chez les personnes âgées, et cherche à déterminer si l’apprentissage de langues étrangères à un âge plus élevé peut constituer une solution optimale pour la construction de la réserve cognitive, étant donné qu’il a été scientifiquement prouvé que l’apprentissage des langues engage un réseau cérébral vaste qui est connu pour se chevaucher avec les régions du cerveau affectées négativement par le processus de vieillissement. Ce document vise à mettre en évidence l’importance du bilinguisme à vie et, en utilisant une perspective différente, de promouvoir l’éducation multilingue durant toute la vie.
In vivo phosphorylation dynamics of the Bordetella pertussis virulence‐controlling response regulator BvgA

We have used protein electrophoresis through polyacrylamide gels derivatized with the proprietary ligand Phos‐tag™ to separate the response regulator BvgA from its phosphorylated counterpart BvgA∼P. This approach has allowed us to readily ascertain the degree of phosphorylation of BvgA in in vitro reactions, or in crude lysates of Bordetella pertussis grown under varying laboratory conditions. We have used this technique to examine the kinetics of BvgA phosphorylation after shift of B. pertussis cultures from non‐permissive to permissive conditions, or of its dephosphorylation following a shift from permissive to non‐permissive conditions. Our results provide the first direct evidence that levels of BvgA∼P in vivo correspond temporally to the expression of early and late BvgA‐regulated virulence genes. We have also examined a number of other aspects of BvgA function predicted from previous studies and by analogy with other two‐component response regulators. These include the site of BvgA phosphorylation, the exclusive role of the cognate BvgS sensor kinase in its phosphorylation in Bordetella pertussis, and the effect of the T194M mutation on phosphorylation. We also detected the phosphorylation of a small but consistent fraction of BvgA purified after expression in Escherichia coli.
Low Risk Emissions Corridors for Safeguarding the Atlantic Thermohaline Circulation

In this paper, we present the integrated assessment model dimrise (dynamic integrated model of regular climate change impacts and singular events). This model is designed to investigate the stability of the North Atlantic thermohaline circulation (THC) and to derive related climate policy recommendations. It is written in GAMS and comprises a dynamic model of the Atlantic overturning coupled to a climate model and a global economy model for assessing the monetary cost of climate protection. The THC model is a dynamic four-box interhemispheric extension of the classic Stommel model calibrated against results obtained using the CLIMBER-2 climate model. The reduced-form climate model used to drive the THC model is the ICLIPS multi-gas climate model, which is a computationally efficient, globally aggregated model able to mimic the response of more sophisticated carbon cycle and atmosphere-ocean general circulation models. The THC and climate modules are coupled to a globally aggregated Ramsey-type optimal growth model of the world economy derived from the Nordhaus DICE model. Together, these components create a novel dynamic fully coupled computationally efficient integrated assessment model. Illustrative applications demonstrate that dimrise is able to derive costeffective emissions paths that comply with prescribed bounds on admissible THC weakening, duly imposed in order to avoid an irrevocable break-down. In addition, emissions corridors are presented which contain all possible emissions paths that do not endanger the stability of the North Atlantic circulation and that simultaneously obey restrictions on welfare loss arising from mitigation efforts. The presented results show that, using a conservative calibration of the model, the North Atlantic circulation may be threatened within two decades in the absence of precautionary mitigation.
Role of Growth Factor Receptors in Neural Stem Cells Differentiation and Dopaminergic Neurons Generation

Neural stem cells (NSCs) are defined as clonogenic cells with self-renewal capacity and multilineage potential (Bazan et al., 2004). Cells with these characteristics have been isolated from the embryonic and adult Central Nervous System (CNS) (Gil-Perotin et al., 2009; Merkle & Alvarez-Buylla, 2006; Weiss et al., 1996). Under specific conditions, these cells proliferate in culture as cell clusters, called neurospheres, and differentiate into neurons, glia, and non-neural cell types (Kennea & Mehmet, 2002; Lobo et al., 2003; Reynolds & Weiss, 1992; Vescovi et al., 2002; Arias-Carrion & Yuan, 2009). Moreover, these cultures represent a potential source for cell replacement therapies in neurological diseases such as Parkinson’s disease (PD) (Bjugstad et al., 2008; Pluchino et al., 2005; Reimers et al., 2011; Zhu et al, 2009).
The Role of Children's Adaptability in Classrooms Characterized by Low or High Teacher Emotional Support Consistency

Abstract. Teachers' social interactions with children are a salient aspect of the classroom environment. An emerging line of research suggests teachers' emotional support consistency is an important predictor of children's academic and social outcomes. Yet individual differences determine the contribution of classroom affordances to children's adjustment. Adaptability describes a child's propensity to perceive and respond to changes in the social environment. Less adaptable children experience change as stressful and tend to be at risk for poor classroom functioning, perhaps more so in classrooms characterized by low levels of emotional support consistency. Multigroup analyses were performed in a structural equation modeling framework to assess the contribution of adaptability assessed in infancy to third-grade achievement and social skills in low- and high-consistency classrooms. Observations of 959 children in 805 third-grade classrooms, direct child assessment, and teacher ratings revealed that adaptability predicted a range of social skill and achievement measures in third-grade classrooms that offered low levels of emotional support consistency. Findings are situated in a goodness-of-fit model.
Lacustrine Nostoc (Nostocales) and associated microbiome generate a new type of modern clotted microbialite

Microbialites are mineral formations formed by microbial communities that are often dominated by cyanobacteria. Carbonate microbialites, known from Proterozoic times through the present, are recognized for sequestering globally significant amounts of inorganic carbon. Recent ecological work has focused on microbial communities dominated by cyanobacteria that produce microbial mats and laminate microbialites (stromatolites). However, the taxonomic composition and functions of microbial communities that generate distinctive clotted microbialites (thrombolites) are less well understood. Here, microscopy and deep shotgun sequencing were used to characterize the microbiome (microbial taxa and their genomes) associated with a single cyanobacterial host linked by 16S sequences to Nostoc commune Vaucher ex Bornet & Flahault, which dominates abundant littoral clotted microbialites in shallow, subpolar, freshwater Laguna Larga in southern Chile. Microscopy and energy‐dispersive X‐ray spectroscopy suggested the hypothesis that adherent hollow carbonate spheres typical of the clotted microbialite begin development on the rigid curved outer surfaces of the Nostoc balls. A surface biofilm included >50 nonoxygenic bacterial genera (taxa other than Nostoc) that indicate diverse ecological functions. The Laguna Larga Nostoc microbiome included the sulfate reducers Desulfomicrobium and Sulfospirillum and genes encoding all known proteins specific to sulfate reduction, a process known to facilitate carbonate deposition by increasing pH. Sequences indicating presence of nostocalean and other types of nifH, nostocalean sulfide:ferredoxin oxidoreductase (indicating anoxygenic photosynthesis), and biosynthetic pathways for the secondary products scytonemin, mycosporine, and microviridin toxin were identified. These results allow comparisons with microbiota and microbiomes of other algae and illuminate biogeochemical roles of ancient microbialites.
Too Many Mutants with Multiple Mutations

ABSTRACT It has recently become clear that the classical notion of the random nature of mutation does not hold for the distribution of mutations among genes: most collections of mutants contain more isolates with two or more mutations than predicted by the mutant frequency on the assumption of a random distribution of mutations. Excesses of multiples are seen in a wide range of organisms, including riboviruses, DNA viruses, prokaryotes, yeasts, and higher eukaryotic cell lines and tissues. In addition, such excesses are produced by DNA polymerases in vitro. These “multiples” appear to be generated by transient, localized hypermutation rather than by heritable mutator mutations. The components of multiples are sometimes scattered at random and sometimes display an excess of smaller distances between mutations. As yet, almost nothing is known about the mechanisms that generate multiples, but such mutations have the capacity to accelerate those evolutionary pathways that require multiple mutations where the individual mutations are neutral or deleterious. Examples that impinge on human health may include carcinogenesis and the adaptation of microbial pathogens as they move between individual hosts.
Neuroprotective effects of Cassia tora against paraquat-induced neurodegeneration: relevance for Parkinson’s disease

Abstract The aim of the present study was to determine whether Cassia tora extracts could reverse the oxidative stress-induced neurodegeneration in a Parkinson’s disease in vitro model. The leaves were treated with ethyl acetate (CtEA) or methanol (CtME). The extracts were first analysed by HPLC for their phenolic content and then tested for their neuroprotective effects in human SK-N-SH neuroblastoma cells. Cells were pre-treated with various concentrations of extracts followed by incubation with paraquat (14 μM). Firstly, pre-treatment of SK-N-SH cells with 100 μg/mL of CtEA or CtME significantly reduced the paraquat-induced production of reactive oxygen species. Furthermore, both CtEA and CtME reduced the paraquat-induced apoptosis. Moreover, there was a significant reduction of paraquat-induced DNA damage in SK-N-SH cells pre-treated with CtEA or CtME. Finally, both extracts significantly inhibited paraquat-dependent lipid peroxidation. Altogether, these in vitro data establish C. tora as a possible anti-Parkinson natural remedy.