Miracle-dz/UniFAR-FTUs huggingface dataset:
Two Phase Iterative Clustering for Educational Data

In the field of data mining, clustering of educational data has not given much of the importance. Considering the growth of educational field as a business, clustering of educational data must be focused as it can give effective results as in the case of mining enrolled students on the basis of education they undertake. A new algorithm is proposed and implemented by us for clustering educational data. This algorithm is based on a continuous looping procedure. Raw dataset is assigned to clustering algorithm initially and a novel cluster is identified for partition whose cluster high degree is less. Then improvement of degree of cluster is carried out. In this algorithm on the basis of homogeneity, cluster high degree is defined. Experiment is carried out on educational data; which provides good high degree clusters.
Treatment of a case of primary alveolar soft part sarcoma of the lung: Case report and literature review

Alveolar soft part sarcoma (ASPS) is an extremely rare type of soft tissue sarcoma. The primary sites of ASPS are mostly located in the extremities and trunk. Primary pulmonary ASPS is extremely rare. A search of the PubMed® database identified only five cases of primary pulmonary ASPS. This current case report describes the sixth case of ASPS in a 15-year-old male that presented with recurrent headaches. Head computed tomography showed space-occupying lesions in the left parietal lobe. Positron emission tomography–computed tomography confirmed the space-occupying lesions in the left parietal lobe and showed multiple nodules and masses in the two lungs and pleura, which were considered to be low-grade malignant mesenchymal tumours. The case report presents the clinical characteristics, diagnosis and treatment process. Programmed cell death protein 1 monoclonal antibody (sintilimab) combined with a tyrosine kinase inhibitor (anlotinib hydrochloride) achieved a good therapeutic effect, indicating that this combination therapy is worth exploring further. Large-scale prospective studies are needed to explore and develop standardized treatments for ASPS.
Intermediate filament network perturbation in the C. elegans intestine causes systemic dysfunctions

Intermediate filaments (IFs) are major components of the metazoan cytoskeleton. A long-standing debate concerns the question whether IF network organization only reflects or also determines cell and tissue function. Using Caenorhabditis elegans, we have recently described mutants of the mitogen-activated protein kinase (MAPK) SMA-5 which perturb the organization of the intestinal IF cytoskeleton resulting in luminal widening and cytoplasmic invaginations. Besides these structural phenotypes, systemic dysfunctions were also observed. We now identify the IF polypeptide IFB-2 as a highly efficient suppressor of both the structural and functional deficiencies of mutant sma-5 animals by removing the aberrant IF network. Mechanistically, perturbed IF network morphogenesis is linked to hyperphosphorylation of multiple sites throughout the entire IFB-2 molecule. The rescuing capability is IF isotype-specific and not restricted to sma-5 mutants but extends to mutants that disrupt the function of the cytoskeletal linker IFO-1 and the IF-associated protein BBLN-1. The findings provide strong evidence for adverse consequences of the deranged IF networks with implications for diseases that are characterized by altered IF network organization.
Repercussions and Legacy of the COVID-19 Pandemic in Manaus, Brazil: The Health Managers’ Perspective

The present study aimed to know and analyze the repercussions and legacy of the COVID-19 pandemic for the Unified Health System from the perspective of health managers working in Manaus, a city considered the epicenter of the pandemic in Brazil. This qualitative research was designed as the study of a single incorporated case and conducted with 23 Health Care Network managers. The analysis was applied in two thematic coding cycles (values and focused coding methods), with the aid of the ATLAS.ti software. The categories we analyzed covered the lessons learned within the scope of the work process, change in stance, and human values, as well as the coping strategies adopted by individual or team initiatives or by the incorporation of innovations in practices. This study highlighted the importance of strengthening primary health care; of promoting team spirit in the service and establishing partnerships with public and private institutions, of being integrated with the training in complex situations, and of reflecting on human values and appreciation of life. Coping with the pandemic promoted an in-depth reflection about the functioning of the Unified Health System and the individual ways of being.
Limit Theory for M-Estimates in an Integrated Infinite Variance

We consider the limiting distributions of M-estimates of an “autoregressive” parameter when the observations come from an integrated linear process with infinite variance innovations. It is shown that M-estimates are, asymptotically, infinitely more efficient than the least-squares estimator (in the sense that they have a faster rate of convergence) and are conditionally asymptotically normal.
Developing a COVID-19 Health Equity Workgroup with CHWs: Answering a Call to Action

Community Health Workers (CHWs) are trusted members of their communities who advocate on behalf of clients, interpret information to ensure that clients are connected to care, and serve as a vital intersection point between clients and their health care providers (Recto et al., 2022). CHWs have the capacity both to build individuals and empower communities to make meaningful changes by increasing health knowledge and advocating for existing community strengths with their deep community connections (Recto et al., 2022). As introduced in a former Cultural Competence Column (Recto et al., 2022), and based on principles of Community-Based Participatory Research (CBPR) (Wallerstein et al., 2018), a group of predominantly CHWs affiliated with the South Texas Area Health Education Center (ST-AHEC) Program co-developed and co-implemented a COVID-19 and Health Equity Project Extension for Community Healthcare Outcomes (ECHO) for CHWs and Promotoras/es. As noted in the literature, CBPR is an invaluable approach to any project development since this model guides both the community and academic partners to interconnect and move flexibly in their co-created project (Anderson et al., 2014). In addition to CBPR principles, we chose to incorporate Freire’s Education Empowerment Pedagogy as its principles also promote the engagement of community members in the development of programs that seek to improve and reduce health disparities (Freire & Ramos, 1970).
De Novo Human Angiotensin-Converting Enzyme 2 Decoy NL-CVX1 Protects Mice From Severe Disease After Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Abstract The emergence of novel variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the need to investigate alternative approaches to prevent infection and treat patients with coronavirus disease 2019. Here, we report the preclinical efficacy of NL-CVX1, a de novo decoy that blocks virus entry into cells by binding with nanomolar affinity and high specificity to the receptor-binding domain of the SARS-CoV-2 spike protein. Using a transgenic mouse model of SARS-CoV-2 infection, we showed that a single prophylactic intranasal dose of NL-CVX1 conferred complete protection from severe disease following SARS-CoV-2 infection. Multiple therapeutic administrations of NL-CVX1 also protected mice from succumbing to infection. Finally, we showed that infected mice treated with NL-CVX1 developed both anti-SARS-CoV-2 antibodies and memory T cells and were protected against reinfection a month after treatment. Overall, these observations suggest NL-CVX1 is a promising therapeutic candidate for preventing and treating severe SARS-CoV-2 infections.
Use of ranked set sampling in nonparametric control charts

Abstract Control charts are widely used to identify changes in a production process. Nonparametric or distribution-free charts can be useful when there is a lack of underlying process distribution. A nonparametric exponentially weighted moving average (EWMA) control chart based on sign test using ranked set sampling (RSS) is proposed to monitor the possible small shifts in the process mean. The performance of the proposed chart is evaluated in terms of average run length, median run length, and standard deviation of the run length distribution. It has been observed that the proposed version of the EWMA sign chart, using RSS shows better detection ability than that version of the EWMA sign chart and the parametric EWMA control chart using simple random sampling scheme. An application with real data-set is also provided to explain the proposal for practical considerations.
Measures of Speech Understanding in Noise for Young Children with a Cochlear Implant in Mainstream and Special Education

The use of two types of speech-in-noise (SPIN) assessment, namely digits-in-noise self-tests and open-set, monosyllabic word tests, to assess the SPIN understanding performance of children with cochlear implants (CI) in mainstream and special education, was investigated. The tests’ feasibility and reliability and the influence of specific cognitive abilities on their results were studied. The results of 30 children with CIs in mainstream and special education were compared to those of 60 normal-hearing children in elementary school. Results indicate that the digit triplet test (DTT) was feasible for all children tested in this study, as seen by the familiarity of all the digits, the high stability of the test results (<3 dB SNR), and a small measurement error (≤2 dB SNR). Remembering full triplets did not form a problem and results did not show systematic attention loss. For children with CIs, the performance on the DTT was strongly related to the performance on the open-set monosyllabic word-in-noise task. However, small but significant differences were observed in the performance of children with CIs in mainstream and special education on the monosyllabic word test. Both tests showed little influence of cognitive abilities, making them both useful in situations where the bottom-up auditory aspect of SPIN performance needs to be investigated or in situations where sentence-in-noise tests are too challenging.
Rising arterial stiffness with accumulating comorbidities associates with heart failure with preserved ejection fraction

Comorbidities play a significant role towards the pathophysiology of heart failure with preserved ejection fraction (HFpEF), characterized by abnormal macrovascular function and altered ventricular–vascular coupling. However, our understanding of the role of comorbidities and arterial stiffness in HFpEF remains incomplete. We hypothesized that HFpEF is preceded by a cumulative rise in arterial stiffness as cardiovascular comorbidities accumulate, beyond that associated with ageing.
Discrepancy estimates for some linear generalized monomials

We consider sequences modulo one that are generated using a generalized polynomial over the real numbers. Such polynomials may also contain the integer part operation [·] additionally to the addition and the multiplication. A well-studied example is the (nα) sequence defined by the monomial αx. Their most basic sister — ([nα]β)n≥0 — is less investigated. So far only the uniform distribution modulo one of these sequences is resolved. Completely new, however, are the discrepancy results proved in this paper. We show in particular that if the pair of real numbers (α, β) is in a certain sense badly approximable, then the discrepancy satisfies a bound of order Oα,β,e(N).
Evaluation of the usage of incisional liposomal bupivacaine as a local anaesthetic for dogs undergoing limb amputation

Abstract Background Bupivacaine lioposomal suspension has recently emerged in the veterinary field for local analgesia. Objective To describe the extra‐label administration of bupivacaine liposomal suspension at the incision site of dogs undergoing limb amputation and characterize any complications. Study Design Nonblinded retrospective study. Animals Client‐owned dogs undergoing limb amputation from 2016 to 2020. Methods Medical records of dogs undergoing limb amputation with concurrent use of long‐acting liposomal bupivacaine suspension were reviewed for incisional complications, adverse effects, hospitalization length, and time to alimentation. Data were compared to a control group (CG) of dogs who underwent a limb amputation procedure without concurrent use of liposomal bupivacaine suspension. Results Forty‐six dogs were included in the liposomal bupivacaine group (LBG) and 44 cases in the CG. The CG had 15 incidences of incisional complications (34%) compared to 6 within the LBG (13%). Four dogs required revisional surgery in the CG (9%) whereas none of the dogs required revisional surgery in the LBG. Time from surgery to discharge was statistically higher in the CG compared to the LBG (p = 0.025). First time to alimentation was statistically higher in the CG (p value = 0.0002). The total number of rechecks needed postoperatively revealed the CG having a statistically significant increase in recheck evaluations (p = 0.001). Conclusions Extra‐label administration of liposomal bupivacaine suspension was well‐tolerated in dogs undergoing limb amputation. Liposomal bupivacaine usage did not increase incisional complication rates and its use allowed for a quicker time to discharge. Clinical significance Surgeons should consider inclusion of extra‐label administration of liposomal bupivacaine in analgesic regimens for dogs undergoing limb amputation.
Effects of 12 weeks of caffeine supplementation and Zumba training on postural balance and cognitive performances in middle-aged women

Abstract The researchers aimed to examine the effect of 12-week supplementing (100 mg/day) caffeine with Zumba training on postural and cognitive performances in middle-aged women. Fifty-six middle-aged women who participated in this study, were randomized into; a caffeine-Zumba (CZG), Zumba (ZG) and control groups. In two-testing sessions, postural balance was evaluated using a stabilometric platform, and for cognitive performances, Simple Reaction Time and Corsi Block-Tapping Task tests were used. We found that ZG and CZG showed a significant improvement in postural balance on the firm surface condition (p < .05) in the post- compared to pretest session. Whereas, ZG showed no significant improvement in postural performance on the foam surface condition. Only CZG revealed significant enhancements (p < .05) in cognitive and postural, in the foam surface condition, performances. In conclusion, supplementing caffeine with 12-week Zumba training was effective in improving both cognitive and postural balance, even in challenging conditions, performances in middle-aged women.
EEG changes as an indication of central nervous system involvement following cyclopentolate 1% eye drops; a randomized placebo-controlled pilot study in a pediatric population

ABSTRACT To compare EEG-patterns after instillation of cyclopentolate versus placebo eye drops. Prospective, randomized, placebo-controlled, and observational pilot study is presented. Ophthalmology outpatient clinic Dutch metropolitan hospital. Healthy 6- to 15-year-old volunteers with normal or low BMI requiring a cycloplegic refraction/retinoscopy. Randomized; 1 visit 2 drops cyclopentolate-1% and 1 visit 2 drops placebo (saline-0.9%). Single-blind: conducting researcher. Double blind: subjects, parents, clinical-neurophysiology staff, neurologist, and statistician. A 10-min baseline EEG-recording, drop-application, and follow-up to at least 45 min. Primary outcome: Detection of CNS changes, i.e. EEG-pattern changes, following two drops of cyclopentolate-1%. Secondary outcome: Determination of the extent of these pattern changes. Thirty-six cyclopentolate-1% saline-0.9% EEG registrations were made in 33 subjects; 18 males and 15 females. Three subjects were tested twice (interval 7 months). Nine out of fourteen (64%) of the 11- to 15-year-old children reported impaired memory, attention, alertness, as well as mind wandering following cyclopentolate. Drowsiness and sleep were seen in EEG-recordings of 11 subjects (33%) following cyclopentolate. We observed no drowsiness nor sleep during placebo recordings. The mean time to drowsiness was 23 min. Nine subjects arrived in stage-3 sleep but none arrived in REM-sleep. In subjects without sleep (N=24), significant changes compared to placebo-EEG were present for many leads and parameters. The main findings during awake eye-open recording were as follows: 1) a significant increase of temporal Beta-1,2 and 3-power, and 2) a significant decrease in: a) the parietal and occipital Alpha-2-power, b) the frontal Delta-1-power, c) the frontal total power, and d) the occipital and parietal activation synchrony index. The former finding reflects cyclopentolate uptake in the CNS, and the latter findings provide evidence for CNS suppression. Cyclopentolate-1% eye drops can affect the CNS and may cause altered consciousness, drowsiness, and sleep with concomitant EEG results in both young children and children in puberty. There is evidence that cyclopentolate has the potency to act as a short acting CNS depressant. Nevertheless, however, cyclopentolate-1% can safely be used in children and young adolescents.
Unlocking Pain Relief for Chronic Low Back Pain: The Potential of the 4xT Method® – A Dual Case Study Analysis

Case series Patient: Female, 42-year-old • Male, 43-year-old Final Diagnosis: Non specific lower back pain Symptoms: Pain • joint mobility impairmen Clinical Procedure: Physical therapy Specialty: Rehabilitation • Traditional Medicine Objective: Unusual setting of medical care Background: The 4xT method is a therapeutic approach involving 10 sequential steps. The 4xT method uses the steps test, trigger, tape, and train, sequentially executed until the patient can train with an acceptable level of pain. The report aimed to evaluate the effectiveness of 4xT therapy in managing chronic nonspecific low back pain (LBP) after the first treatment and after 6 weeks of therapy by measuring changes in range of motion (ROM) and pain levels using the numeric rating scale (pain NRS). Case Reports: After the first treatment, patient 1 (42-year-old woman with 16 years of LBP, having a profession requiring standing) improved substantially in ROM, increasing flexion from 57° to 104° and extension from 5° to 21°. The pain NRS during flexion decreased from 8 to 0 (after step 6), and during extension, it decreased from 6 to 0 (after step 7). Similarly, patient 2 (43-year-old man with 13 weeks of LBP, having a sedentary occupation) showed ROM improvements, increasing extension from 16° to 25° and flexion from 58° to 101°. After step 8, pain NRS during extension decreased from 7 to 1, and during flexion, it decreased from 6 to 2 (after step 3). Pain further reduced to NRS0 after training. After 6 weeks of 4xT therapy, LBP improved, and mobility substantially increased in both patients. Conclusions: The 4xT method was effective in reducing pain and improving mobility in 2 LBP patients after initial treatment and 6 weeks of therapy. Further research is necessary to validate these results in larger populations.
Polarization-dependent perfect absorbers/reflectors based on a three-dimensional metamaterial

Conventionally a flat, shiny metal surface can be used as a reflector. Here we show that a microstructured metal surface can be switched from a perfect reflector to a perfect absorber by merely changing the polarization of the incident light. The structure consists of arrays of three-dimensional standing U-shaped resonators (SUSRs), which are fabricated by two-photon polymerization followed by blanket coating of the metal. For the incidence with a specific polarization, light can be perfectly reflected. By changing the polarization of incident light for 90\ifmmode^\circ\else\textdegree\fi{}, light neither transmits nor reflects. Since the electromagnetic resonance occurs in between the standing arms of a U-shaped resonator, the heat generated in the absorption process is expected to dissipate more easily. The thermal stability of the SUSR absorber has also been investigated.
FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA

Significance MHC class II (MHC-II) molecules are essential for both humoral and cellular immunity as they are required for CD4+ T cell activation through antigen presentation. The expression of MHC-II requires the activity of a master regulator, CIITA. Although posttranslational regulation is critical for CIITA activity, the regulation of CIITA protein has been poorly understood. Here, we report that an E3 ligase, FBXO11, ubiquitinates and degrades CIITA through the ubiquitin–proteasome system, thereby suppressing MHC-II expression. FBXO11 expression levels were negatively correlated with MHC-II expression in both normal and cancer cells. Our findings elucidate molecular mechanism that regulates CIITA at the protein level and determine MHC-II expression level, which may provide a therapeutic target for inflammatory diseases and cancer.
Elemental stoichiometry of the key calcifying marine phytoplankton Emiliania huxleyi under ocean climate change: A meta‐analysis

The elemental composition of marine microorganisms (their C:N:P ratio, or stoichiometry) is central to understanding the biotic and biogeochemical processes underlying key marine ecosystem functions. Phytoplankton C:N:P is species specific and flexible to changing environmental conditions. However, bulk or fixed phytoplankton stoichiometry is usually assumed in biogeochemical and ecological models because more realistic, environmentally responsive C:N:P ratios have yet to be defined for key functional groups. Here, a comprehensive meta‐analysis of experimental laboratory data reveals the variable C:N:P stoichiometry of Emiliania huxleyi, a globally significant calcifying phytoplankton species. Mean C:N:P of E. huxleyi is 124C:16N:1P under control conditions (i.e. growth not limited by one or more environmental stressors) and shows a range of responses to changes in nutrient and light availability, temperature and pCO2. Macronutrient limitation caused strong shifts in stoichiometry, increasing N:P and C:P under P deficiency (by 305% and 493% respectively) and doubling C:N under N deficiency. Responses to light, temperature and pCO2 were mixed but typically shifted cellular elemental content and C:N:P stoichiometry by ca. 30% or less. Besides these independent effects, the interactive effects of multiple environmental changes on E. huxleyi stoichiometry under future ocean conditions could be additive, synergistic or antagonistic. To synthesise our meta‐analysis results, we explored how the cellular elemental content and C:N:P stoichiometry of E. huxleyi may respond to two hypothetical future ocean scenarios (increased temperature, irradiance and pCO2 combined with either N deficiency or P deficiency) if an additive effect is assumed. Both future scenarios indicate decreased calcification (which is predominantly sensitive to elevated pCO2), increased C:N, and up to fourfold shifts in C:P and N:P. Our results strongly suggest that climate change will significantly alter the role of E. huxleyi (and potentially other calcifying phytoplankton species) in marine biogeochemical processes.