Miracle-dz/UniFAR-FTUs huggingface dataset:
Design of a Dual-Band Frequency Reconfigurable Patch Antenna Based on Characteristic Modes

A frequency reconfigurable patch antenna design based on the characteristic mode analysis is presented. The antenna presents a reconfigurable lower band and a steady band at higher frequencies. A slot is etched on the ground plane of the antenna, where two varactor diodes are placed on each side of the slot in order to tune the lower band. The first resonant frequency shifts down by varying the reverse voltage of the varactor, whereas the second operating frequency keeps stable. The proposed antenna is designed to cover WLAN bands, offering a first band operating at 2 GHz and a second band ranging from 5.3 GHz to 5.8 GHz. A prototype has been fabricated and measurements are provided, which validate the proposed analysis, method, and design procedure.
ADNEX risk prediction model for diagnosis of ovarian cancer: systematic review and meta-analysis of external validation studies

Objectives To conduct a systematic review of studies externally validating the ADNEX (Assessment of Different Neoplasias in the adnexa) model for diagnosis of ovarian cancer and to present a meta-analysis of its performance. Design Systematic review and meta-analysis of external validation studies Data sources Medline, Embase, Web of Science, Scopus, and Europe PMC, from 15 October 2014 to 15 May 2023. Eligibility criteria for selecting studies All external validation studies of the performance of ADNEX, with any study design and any study population of patients with an adnexal mass. Two independent reviewers extracted the data. Disagreements were resolved by discussion. Reporting quality of the studies was scored with the TRIPOD (Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis) reporting guideline, and methodological conduct and risk of bias with PROBAST (Prediction model Risk Of Bias Assessment Tool). Random effects meta-analysis of the area under the receiver operating characteristic curve (AUC), sensitivity and specificity at the 10% risk of malignancy threshold, and net benefit and relative utility at the 10% risk of malignancy threshold were performed. Results 47 studies (17 007 tumours) were included, with a median study sample size of 261 (range 24-4905). On average, 61% of TRIPOD items were reported. Handling of missing data, justification of sample size, and model calibration were rarely described. 91% of validations were at high risk of bias, mainly because of the unexplained exclusion of incomplete cases, small sample size, or no assessment of calibration. The summary AUC to distinguish benign from malignant tumours in patients who underwent surgery was 0.93 (95% confidence interval 0.92 to 0.94, 95% prediction interval 0.85 to 0.98) for ADNEX with the serum biomarker, cancer antigen 125 (CA125), as a predictor (9202 tumours, 43 centres, 18 countries, and 21 studies) and 0.93 (95% confidence interval 0.91 to 0.94, 95% prediction interval 0.85 to 0.98) for ADNEX without CA125 (6309 tumours, 31 centres, 13 countries, and 12 studies). The estimated probability that the model has use clinically in a new centre was 95% (with CA125) and 91% (without CA125). When restricting analysis to studies with a low risk of bias, summary AUC values were 0.93 (with CA125) and 0.91 (without CA125), and estimated probabilities that the model has use clinically were 89% (with CA125) and 87% (without CA125). Conclusions The results of the meta-analysis indicated that ADNEX performed well in distinguishing between benign and malignant tumours in populations from different countries and settings, regardless of whether the serum biomarker, CA125, was used as a predictor. A key limitation was that calibration was rarely assessed. Systematic review registration PROSPERO CRD42022373182.
Advancing green computing: Practices, strategies, and impact in modern software development for environmental sustainability

Advancing Green Computing: Practices, Strategies, and Impact in Modern Software Development for Environmental Sustainability explores the evolving landscape of green computing within the realm of software development, emphasizing the imperative for environmentally sustainable practices. In response to escalating environmental concerns, the computing industry is undergoing a paradigm shift towards reducing its carbon footprint and mitigating ecological impacts. This shift is particularly crucial in software development, given its pervasive influence on technological ecosystems. The review delves into the multifaceted dimensions of green computing, elucidating various practices and strategies that are instrumental in fostering environmental sustainability. From optimizing code efficiency to embracing energy-efficient computing architectures, the review underscores the diverse approaches available to software developers in minimizing resource consumption and carbon emissions. Furthermore, it examines the broader ramifications of these practices, emphasizing their potential to reshape the software industry's ecological footprint and contribute to global efforts for environmental conservation. Moreover, the review highlights the symbiotic relationship between green computing and modern software development methodologies. It elucidates how principles such as agile development and DevOps can be synergistically integrated with green computing practices to enhance sustainability throughout the software development lifecycle. By adopting an interdisciplinary approach that integrates environmental considerations into software design, development, and deployment processes, organizations can catalyze transformative changes towards a greener computing ecosystem. The review also investigates the tangible impact of green computing practices on environmental sustainability metrics. Through case studies and empirical analyses, it showcases the efficacy of various strategies in reducing energy consumption, carbon emissions, and electronic waste generation. Additionally, it discusses the economic and societal benefits accrued from adopting environmentally sustainable practices, ranging from cost savings to enhanced corporate social responsibility. Advancing Green Computing: Practices, Strategies, and Impact in Modern Software Development for Environmental Sustainability provides a comprehensive overview of the evolving landscape of green computing within the context of software development. It elucidates the myriad opportunities and challenges associated with fostering environmental sustainability in the computing industry and underscores the transformative potential of integrating green computing principles into modern software development practices.
A DOA Estimation Method Based on an Improved Transformer Model for Uniform Linear Arrays with Low SNR

In this paper, the Star-Transformer model is improved to obtain more accurate direction of arrivals (DOA) estimation of underwater sonar uniform linear array (ULA) under low signal-to-noise ratio (SNR) conditions. The ideal real covariance matrix is divided into three channels: real part channel, imaginary part channel, and phase channel to obtain more input features. In training, the real covariance matrix is used under different SNRs. In testing, the covariance matrix of samples in the real environment is used as input. The on-grid form is used to estimate the DOA of multiple signal sources, which is modelled as a multilabel classification problem. The results show that the model can be effective and can still have a good DOA estimation performance under the conditions of trained and untrained SNRs, different snapshots, signal power mismatch, different separation angles, signal correlation, and so on. It shows that the model has excellent robustness.
Stress Response to Various Stimuli of Major Aquaculture Fish in Japan

Stress affects the sensitivity of the immune response and the occurrence of infectious disease in fish. Various stimuli subject aquaculture fish to stress and the degree of the stress differs depending on the stimuli. In this study, various stimuli (lifting in the air with a net, lowering the water level, leaving in fresh water, leaving in formalin solution, and injecting at the abdominal cavity) were applied to yellowtail Seriola quinqueradiata (mean 115 g), red sea bream Pagrus major (mean 162 g), and flounder Paralichthys olivaceus (mean 281 g), which are the main cultured marine fish in Japan. The blood glucose concentration in each fish species was then measured and the degree of stress was determined. The results indicated that reactions to each stimuli differed depending on the fish species. Highest concentrations of glucose were seen in the yellowtail injected at the abdominal cavity, the red sea bream left in formalin solution, and the flounder left in fresh water. The time required for the concentration of blood glucose to return to normal level also differed in each fish species. Results indicated that many of the procedures utilized in fish rearing cause stress.
Preclinical evaluation of the third-generation, bi-steric mechanistic target of rapamycin complex 1-selective inhibitor RMC-6272 in NF2-deficient models

Abstract Background NF2-associated meningiomas are progressive, highly morbid, and nonresponsive to chemotherapies, highlighting the need for improved treatments. We have established aberrant activation of the mechanistic target of rapamycin (mTOR) signaling in NF2-deficient tumors, leading to clinical trials with first- and second-generation mTOR inhibitors. However, results have been mixed, showing stabilized tumor growth without shrinkage offset by adverse side effects. To address these limitations, here we explored the potential of third-generation, bi-steric mTOR complex 1 (mTORC1) inhibitors using the preclinical tool compound RMC-6272. Methods Employing human NF2-deficient meningioma lines, we compared mTOR inhibitors rapamycin (first-generation), INK128 (second-generation), and RMC-6272 (third-generation) using in vitro dose–response testing, cell-cycle analysis, and immunoblotting. Furthermore, the efficacy of RMC-6272 was assessed in NF2-null 3D-spheroid meningioma models, and its in vivo potential was evaluated in 2 orthotopic meningioma mouse models. Results Treatment of meningioma cells revealed that, unlike rapamycin, RMC-6272 demonstrated superior growth inhibitory effects, cell-cycle arrest, and complete inhibition of phosphorylated 4E-BP1 (mTORC1 readout). Moreover, RMC-6272 had a longer retention time than INK128 and inhibited the expression of several eIF4E-sensitive targets on the protein level. RMC-6272 treatment of NF2 spheroids showed significant shrinkage in size as well as reduced proliferation. Furthermore, in vivo studies in mice revealed effective blockage of meningioma growth by RMC-6272, compared with vehicle controls. Conclusions Our study in preclinical models of NF2 supports possible future clinical evaluation of third-generation, investigational mTORC1 inhibitors, such as RMC-5552, as a potential treatment strategy for NF2.
Steps for Future Progress in Ecosystem-based Fisheries Management: What’s Next?

Kruse, G.H. , H.I. Browman, K.L. Cochrane, D. Evans, W.J. Fletcher, G.S. Jamieson, P.A. Livingston, D. Woodby, and C.I. Zhang. 2012. Steps for Future Progress in Ecosystem-based Fisheries Management: What’s Next? In: G.H. Kruse, H.I. Browman, K.L. Cochrane, D. Evans, G.S. Jamieson, P.A. Livingston, D. Woodby, and C.I. Zhang (eds.), Global Progress in Ecosystem-Based Fisheries Management. Alaska Sea Grant, University of Alaska Fairbanks. doi:10.4027/gpebfm.2012. 019
Spatial characteristics of storm‐total rainfall swaths associated with tropical cyclones over the Eastern United States

The eastern United States is extremely vulnerable to Atlantic basin tropical cyclones (TCs) and their associated precipitation. While many studies have focused on the magnitude or contribution of tropical cyclone precipitation (TCP) to overall rainfall, there is a need for a detailed climatology of spatial characteristics of inland TCP extent for this region. In this study, we develop a Geographic Information System method to delineate rainfall swaths for 257 US landfalling TCs during 1948 to 2014 using a daily gridded dataset. We then describe spatial patterns of TCP using three methods. First, we measure the rainfall swath areas and average widths over land, and find that TCs that spend longer periods over land have wider average widths so that rainfall swaths cover larger areas. Second, trends in the change of left extent of TCP swaths are analysed and TC attributes related to these trends are explored. Seventy of 85 TCs have rain swaths that expand on the left side at some points as they move inland. The TCs exhibiting expansion were hurricanes at landfall, re‐intensifying over land, undergoing extratropical transition, and/or moving near the coastline. Last, we construct a series of maps with return intervals and frequency distributions for inland TCP and tropical storm‐force winds. The results show that 94% of 2435 counties over the eastern United States are more frequently exposed to rainfall than wind from TCs. While cumulative rainfall shows a gradual decrease from southeastern coast inland, many inland regions have received five to six TCP events in a single season, which confirms that TCP should be a concern for people living inland as well as near the coast. This study's analysis of the spatial characteristics of TCP inland extent from a climatological perspective should benefit forecasting, hazard mitigation, and risk analysis of TC hazards.
Modified Constraint Induced Movement Therapy for Lower Extremities’ Rehabilitation in Patients with Stroke: A Narrative Review of Literature

Background: Learned non-use is a common complication after stroke in patients who neglects the use of the affected limb for longer periods. Modified Constraint Induced Movement Therapy (m-CIMT) is a form of rehabilitation therapy that limits the unaffected side and through repeated and concentrated training improve the function of the paretic side. Use of m-CIMT for lower extremities rehabilitation is relatively less explored avenue. Aim of the present study was to review literature evaluating the effectiveness of m-CIMT for recovery of lower extremities (LE) function in stroke patients. Methodology: Articles published in English language from 2011 to 2022 were searched from various online databases. Out of total 6 search results, 5 full texts were screened and selected for review based on selection criteria. The review included randomized control trial, pilot study, and experimental study designs. Result: The review of available literature suggested that m-CIMT is an effective approach for LE rehabilitation in stroke patient. It has showed promising results on outcomes such as gait parameters, balance, ambulation, and symmetry. Conclusion: Based on this review, it can be concluded that m-CIMT intervention is effective for rehabilitation of paretic LE function in patient with stroke and therefore it may be used in addition to a conventional treatment. Key words: Balance, gait, lower extremity function, modified constraint induced movement therapy, rehabilitation, stroke.
Differential effects of SORL1 deficiency on the endo-lysosomal network in human neurons and microglia

The endosomal gene SORL1 is a strong Alzheimer's disease (AD) risk gene that harbours loss-of-function variants causative for developing AD. The SORL1 protein SORL1/SORLA is an endosomal receptor that interacts with the multi-protein sorting complex retromer to traffic various cargo through the endo-lysosomal network (ELN). Impairments in endo-lysosomal trafficking are an early cellular symptom in AD and a novel therapeutic target. However, the cell types of the central nervous system are diverse and use the ELN differently. If this pathway is to be effectively therapeutically targeted, understanding how key molecules in the ELN function in various cell types and how manipulating them affects cell-type specific responses relative to AD is essential. Here, we discuss an example where deficiency of SORL1 expression in a human model leads to stress on early endosomes and recycling endosomes in neurons, but preferentially leads to stress on lysosomes in microglia. The differences observed in these organelles could relate to the unique roles of these cells in the brain as neurons are professional secretory cells and microglia are professional phagocytic cells. Experiments to untangle these differences are fundamental to advancing the understanding of cell biology in AD and elucidating important pathways for therapeutic development. Human-induced pluripotent stem cell models are a valuable platform for such experiments. This article is part of a discussion meeting issue ‘Understanding the endo-lysosomal network in neurodegeneration’.
Antifungal activity of Allyl isothiocyanate by targeting signal transduction pathway, ergosterol biosynthesis, and cell cycle in Candida albicans

Background and Purpose: In recent years, the inclusion of Candida albicans on the list of infections that pose a threat due to drug resistance has urged researchers to look into cutting-edge and effective antifungal medications. In this regard, the current study investigated the probable mode of action of allyl isothiocyanate (AITC) against Candida albicans. Materials and Methods: In this study, planktonic assay, germ tube inhibition assay, adhesion, and biofilm formation assay were performed to check the growth and virulence factors. Furthermore, ergosterol assay, reactive oxygen production analysis, cell cycle analysis, and quantitative real-time polymerase chain reaction analysis were performed with the aim of finding the mode of action. A biomedical model organism, like a silkworm, was used in an in vivo study to demonstrate AITC anti-infective ability against C. albicans infection. Results: Allyl isothiocyanate completely inhibited ergosterol biosynthesis in C. albicans at 0.125 mg/ml. Allyl isothiocyanate produces reactive oxygen species in both planktonic and biofilm cells of C. albicans. At 0.125 mg/ml concentration, AITC arrested cells at the G2/M phase of the cell cycle, which may induce apoptosis in C. albicans. In quantitative real-time polymerase chain reaction analysis, it was found that AITC inhibited virulence factors, like germ tube formation, at 0.125 mg/ml concentration by downregulation of PDE2, CEK1, TEC1 by 2.54-, 1.91-, and 1.04-fold change, respectively, and upregulation of MIG1, NRG1, and TUP1 by 9.22-, 3.35-, and 7.80-fold change, respectively. The in vivo study showed that AITC treatment successfully protected silkworms against C. albicans infections and increased their survival rate by preventing internal colonization by C. albicans. Conclusion: In vitro and in vivo studies revealed that AITC can be an alternative therapeutic option for the treatment of C. albicans infection.
Comparison of the effects of itraconazole and prednisolone on fibroblast growth factor-2 gene expression and clinical manifestations in patients with persistent severe asthma

Background and Purpose: Considering the possible role of fungal sensitization in the treatment of resistant asthma, which may lead to the remodeling of bronchial structure, we theorized that itraconazole could result in better control of asthma. In this regard, this study aimed to compare the effects of itraconazole and prednisolone (routinely prescribed) on clinical, structural, and biomarker findings of the remodeling of asthma. Materials and Methods: This double-blind controlled randomized clinical trial was performed on 70 adult patients suffering from severe persistent asthma. The intervention group received 200 mg of itraconazole per day, and the control group received 10 mg of prednisolone per day, for 32 weeks, in addition to the classic treatment of asthma. The subjects were randomly divided into two groups, and assigned by sealed envelope. Blinding was performed by repacking the drug in a similar container. Primary outcomes were asthma control test score, fibroblast growth factor 2, and wall area percentage on RB1 bronchus measured by computed tomography. The outcomes were compared in subjects classified as allergic, eosinophilic, T2 low asthma, and four types of inflammatory cell classification in sputum. Results: Seventy subjects finished the 32-week trial (35 subjects in each group). Baseline data did not show significant differences between groups. A comparison of asthma variants showed significantly more severe cough and dyspnea in the allergic variant and higher spirometry results in T2-low asthma. Sputum cytology revealed a mixed pattern as the most frequent type (47%). After the trial, two groups improved in many parameters; however, FGF-2 improved more significantly by itraconazole (4.66±16.92 decreased to 1.14±2.98), and FEV1/FVC was significantly higher in the itraconazole group, compared to the control group. These results did not change in terms of asthma variants and sputum classification. Conclusion: Itraconazole was superior to prednisolone in the treatment of many clinical and spirometry aspects in severe persistent asthma.
Green and red fluorescent strains of Xenorhabdus griffiniae HGB2511, the bacterial symbiont of the nematode Steinernema hermaphroditum (India)

Steinernema entomopathogenic nematodes form specific, obligate symbiotic associations with gram-negative, gammaproteobacteria members of the Xenorhabdus genus. Together, the nematodes and symbiotic bacteria infect and kill insects, utilize the nutrient-rich cadaver for reproduction, and then reassociate, the bacteria colonizing the nematodes’ anterior intestines before the nematodes leave the cadaver to search for new prey. In addition to their use in biocontrol of insect pests, these nematode-bacteria pairs are highly tractable experimental laboratory models for animal-microbe symbiosis and parasitism research. One advantageous feature of entomopathogenic nematode model systems is that the nematodes are optically transparent, which facilitates direct observation of nematode-associated bacteria throughout the lifecycle. In this work, green- and red-fluorescently labeled X. griffiniae HGB2511 bacteria were created and associated with their S . hermaphroditum symbiotic nematode partners and observed using fluorescence microscopy. As expected, the fluorescent bacteria were visible as a colonizing cluster in the lumen of the anterior intestinal caecum of the infective stage of the nematode. These tools allow detailed observations of X. griffiniae localization and interactions with its nematode and insect host tissues throughout their lifecycles.
Profiles of Cultural Adaptation and Parenting Approach for Childhood Obesity in Lifestyle Interventions for Families With Young Children

Background and Objectives: Various interventions aim to reduce obesity and promote healthy lifestyles among different cultural groups. Methods: We have conducted a systematic literature review, following PRISMA guidelines (registered at https://doi.org/10.17605/OSF.IO/HB9AX), to explore profiles of cultural adaptation and parenting approach of lifestyle interventions for families with young children (1-4 years). Results: Our search (in CINAHL, ERIC, PsycINFO, PubMed, Scopus, and SSCI) yielded 41 studies reporting 31 interventions. Drawing on Intervention Mapping, we applied a newly developed framework with various indicators of cultural adaptation and a parenting approach to analyze interventions. Our review shows clear differences in the level of cultural adaptation. A categorical principal component analysis revealed 6 different empirical profiles of cultural adaptation. Conclusions: Based on our profiles, we discuss how cultural adaptation can be strengthened in the design of future early interventions aimed at promoting a healthy lifestyle.