Miracle-dz/UniFAR-FTUs huggingface dataset:
Portable Electromyography: A Case Study on Ballistic Finger Movement Recognition

In the neuromuscular analysis, electromyography (EMG) is typically used to analyze aggregate action potential (AP) signals to detect medical abnormalities, activation levels, and recruitment order, or analyze biomechanics. In our previous work, we compared the performance of these off-the-shelf solutions to research-grade EMG machines and found that due to their rigid electrode placement, low sampling rate, and data transmission medium, they are ill-suited for research use, in which data collection must be robust and accurate. We present XTREMIS: a low-cost and portable EMG platform with a small form factor (55 mm $\times$ 35 mm) that has a sample rate comparable to research-grade EMG machines. Indeed, the experiments on eight subjects have shown that not only does XTREMIS functionally outperform technologies, but also its signal quality is high enough to achieve finger movement classification accuracy similar to research-grade EMG machines, making it a suitable platform for research.
Operational Modelling with Health Economics to Support Decision Making for COPD Patients

Objective To assess the impact of interventions for improving the management of chronic obstructive pulmonary disease (COPD), specifically increased use of pulmonary rehabilitation (PR) on patient outcomes and cost-benefit analysis. Data sources We used the national Hospital Episode Statistics (HES) datasets in England, local data and experts from the hospital setting, National Prices and National Tariffs, reports and the literature around the effectiveness of PR programmes.
Expression of the High-Afﬁnity Choline Transporter, CHT1, in the Neuronal and Non-neuronal Cholinergic System of Human and Rat Skin

Choline is an essential component in acetylcholine biosynthesis, and is involved in cell signaling. It is unable to permeate the cell membrane and requires a transporter to enter the cell. Neurons that synthesize acetylcholine take up choline by a recently cloned high-afﬁnity choline transporter (choline transporter 1) that is Na + -dependent and can be blocked by hemicholinium-3. The aim of this study was to determine the expression and to analyze the distribution of choline transporter 1 in human and rat skin. The mRNA for choline transporter 1 was detected in rat and human skin and in the human keratinocyte cell line HaCaT. A polyclonal anti-serum was developed against the N-terminal region of the human and rat protein. In rat and human skin, choline transporter 1 immunoreactivity was present in nerve ﬁbers. In addition, keratinocytes, HaCaT cells and cells of the internal root sheath of the hair follicle contained choline transporter 1 immunoreactivity. The labeling patterns of nonconﬂuent vs conﬂuent cultured cells and the distribution of choline transporter 1 along the epidermal layer suggest an association of choline transporter 1 with keratinocyte differentiation. In conclusion, this study shows the presence of the high-afﬁnity choline transporter choline transporter 1 in nerve ﬁbers and epithelial cells in the human and rat skin supporting the pivotal role of this transporter in both the neuronal and non-neuronal cholinergic sys-tem of the skin
Human Mutation

Funding information Preferred Research Foundation for the Returned Overseas Scholars from Ministry of Human Resources and Social Security of China. , Grant/Award Number: LXKY‐201701; National Natural Science Foundation of China, Grant/Award Numbers: U1505222, grant 81500980; Joint Funds for the Innovation of Science and Technology of Fujian Province, Grant/Award Number: 2017Y9094; National Key Clinical Specialty Discipline Construction Program; Key Clinical Specialty Discipline Construction Program of Fujian Abstract Intermediate Charcot‐Marie‐Tooth (CMT) disease is a heterogeneous group of inherited neuropathies characterized by progressive muscle weakness and atrophy of the distal extremities, distal sensory loss. There were still a large proportion of causative genes for intermediate CMT failed to be identified. Here, using whole‐ exome sequencing technique, we identified two novel missense mutations in ATP1A1 gene, c.620C>T (p.S207F) and c.2629G>A (p.G877S), in two Chinese CMT families. Further functional analysis revealed that these mutations led to the loss function of the ATP1A1 protein. The two mutations did not affect the levels of messenger RNA but possessed a damaging effect on ATP1A1 protein expression and they downregulated the protein levels of ATP1A1 by promoting its proteasome degradation. Taken together, we confirmed ATP1A1 as a novel causative gene for intermediate CMT.
Advanced database mining of efﬁcient haloalkane dehalogenases by sequence and structure bioinformatics and microﬂuidics

We present a pipeline integrating sequence and structural bioinformatics with microﬂuidic enzymology to discover efﬁcient and robust haloalkane dehalogenases. Our smart bioinformatic identiﬁcation of promising candidates in genomic databases is followed by efﬁcient microﬂuidic characterization, in terms of activity, speciﬁcity, stability
New eﬀiciency-stability criterion for flow shop rescheduling problem with mixed blocking constraints

: New jobs arrival, jobs cancelation or machine breakdowns, are unexpected events that may occur during production run in real environments, thus disrupting the established schedule. Hence, rescheduling process is necessary for efficiently revising the initial schedule, preferably with little movements. In the literature, many scheduling problems consider unlimited buffer spaces between successive machines in flow shop environments. However, in real life systems, the capacity between machines may be limited or no-store existing. To fill the void, this paper considers a flow shop rescheduling problem with mixed blocking constraints, under disruptions caused by new jobs arrival. A new performance measure is investigated, considering simultaneously the schedule efficiency measured by the total weighted waiting time
CSUSB ScholarWorks CSUSB ScholarWorks

Data clustering plays an important role in effective analysis of gene expression. Although DNA microarray technology facilitates expression monitoring, several challenges arise when dealing with gene expression datasets. Some of these challenges are the enormous number of genes, the dimensionality of the data, and the change of data over time. The genetic groups which are biologically interlinked can be identified through clustering. This project aims to clarify the steps to apply clustering analysis of genes involved in a published dataset. The methodology for this project includes the selection of the dataset representation, the selection of gene datasets, Similarity Matrix Selection, the selection of clustering algorithm, and analysis tool. R language with the focus of Kmeans, fpc, hclust, and heatmap3 packages in R is used in this project as an analysis tool. Different clustering algorithms are used on Spellman dataset to illustrate how genes are grouped together in clusters which help to understand our genetic behaviors.
Wood-loving magic mushrooms from Australia are saprotrophic invaders in the northern hemisphere

Magic mushrooms are fungi that produce psilocybin, a compound with breakthrough status for treatment of mental health disorders. Wood-degrading species of Psilocybe , such as P . subaeruginosa and relatives, have high concentrations of psilocybin but are discouraged for clinical production due to a temporary paralytic side eﬀect known as Wood Lover’s Paralysis, the cause of which is unknown. We studied P. subaeruginosa over its partial distribution in Australia based on genomic analyses of 89 isolates to investigate population structure and species boundaries, examine allelic diversity at psilocybin loci, and test its centre of origin. Psilocybe subaeruginosa is structured by geography in Australia, but geographically separated populations are fully sexually compatible. Allelic diversity among populations, such as at mating compatibility loci, is likely a result of genetic drift and minimal gene ﬂow since diﬀerentiation from a shared ancestor. Movement of woodchips, mulch, or plants has most likely spread genotypes of P. subaeruginosa locally within Australia and to the northern hemisphere. Species from the northern hemisphere, namely P. azurescens and P. cyanescens , clustered among Australian populations, indicating shared ancestry and supporting a hypothesis these taxa are conspeciﬁc with P. subaeruginosa . We identiﬁed high allelic diversity in genes of the psilocybin metabolic pathway and haplotypes of P. subaeruginosa with either one or two putatively functional paralogs of psiH , however the functionality of this gene duplication is yet to be determined. Our study provides insights into the evolutionary history and species boundaries of P. subaeruginosa , which has a centre of origin in Australasia.
Wrapped input selection using multilayer perceptrons for repeat-purchase modeling in direct marketing

In this paper, we try to validate existing theory on and develop additional insight into repeat-purchase behavior in a direct marketing setting by means of an illuminating case study. The case involves the detection and qualification of the most relevant RFM (Recency, Frequency and Monetary) variables, using a neural network wrapper as our input pruning method. Results indicate that elimination of redundant and/or irrelevant inputs by means of the discussed input selection method allows us to significantly reduce model complexity without degrading the predictive generalization ability. It is precisely this issue that will enable us to infer some interesting marketing conclusions concerning the relative importance of the RFM predictor categories and their operationalizations. The empirical findings highlight the importance of a combined use of RFM variables in predicting repeat-purchase behavior. However, the study also reveals the dominant role of the frequency category. Results indicate that a model including only frequency variables still yields satisfactory classification accuracy compared to the optimally reduced model.
Fungal Systematics and Evolution

Coprophilous fungi are saprotrophic organisms that show great diversity, mainly on herbivore dung. The physico-chemical characteristics of this peculiar substrate combined with the high level of fungal adaptation to different environmental conditions offer the perfect setting for discovering new taxa. This study focused on the species diversity of penicillium-like fungi isolated mainly from herbivore dung collected at different Spanish locations. From 130 samples, a total of 104 isolates were obtained, and 48 species were identified. Preliminary identifications were based on morphology and partial β-tubulin (tub2) gene sequences. Putative new taxa were characterized by a multi-gene sequencing analysis testing the tub2, the internal transcribed spacer rDNA (ITS), calmodulin (cmdA), and RNA polymerase II second largest subunit (rpb2) genes, and a detailed phenotypic study. Using this polyphasic approach and following the genealogical concordance phylogenetic species recognition (GCPSR) method, we propose the new genera Penicillago (for Penicillium nodositatum) and Pseudopenicillium (for Penicillium megasporum and P. giganteum) in the family Aspergillaceae, and 11 new species, including seven Penicillium, three Talaromyces and one Pseudopenicillium. A lectotype and epitype are designed for Penicillium nodositatum. Our results show that the species diversity of penicillium-like fungi on herbivore dung has not been widely studied and that this substrate seems to be a good reservoir of interesting Eurotialean fungi.
16. OXYGEN- AND CARBON-ISOTOPE VARIATIONS AND PLANKTONIC-FORAMINIFER DEPTH HABITATS, LATE CRETACEOUS TO PALEOCENE, CENTRAL PACIFIC, DEEP SEA DRILLING PROJECT SITES 463 AND 465

The purpose of this study was to measure the carbonand oxygen-isotope ratios through the upper Cretaceous and across the Cretaceous/Tertiary boundary in the Pacific Ocean (Fig. 1). Deep Sea Drilling Project Site 465 was chosen because of the good to very good preservation of its Cretaceous faunas and a very well-preserved, 100-cm-long, earliest Tertiary "Globigerina" eugubina Zone. The longer section at Site 463 was also measured, where preservation permitted. We made reconnaissance measurements (one per planktonic zone) of the upper Cretaceous from the Turonian through the Maastrichtian. Sampling across the Cretaceous/Tertiary boundary through the early "G. "eugubina Zone. Samples were zoned according to the zonation of van Hinte (1976) for the Cretaceous, and Premoli-Silva and Bolli (1975) for the Paleocene. Unispecific samples of size-graded planktonic foraminifers and uniand multispecific samples of benthic foraminifers were measured. Methods of Shackleton are described in Shackleton and Opdyke (1974). We assumed that the oxygen-isotope ratio records temperature through this time, and we made a correction of 1 . OO%o to SMOW when converting to temperature. The most negative oxygen-isotope planktonic value is used to construct near-surface paleotemperature curves.
Numerical analysis on mining-induced fracture development around river valleys

ABSTRACT This paper presents a detailed study of the mechanisms contributing to fracture development around river valleys associated with mining operations. Due to the geology and geomorphology of the Southern Coalfield of New South Wales, Australia, non-conventional subsidence effects usually occur. The influences associated with valley closure and upsidence are principally tensile and shear fracturing/cracking of the river and underlying strata, which act as underground flow paths for surface water. This paper explicitly simulates the mining-induced fracture development around the valley structure, utilising a distinct element method modelling technique with Voronoi tessellation. The fracture propagations within intact rock as well as along existing discontinuities are simulated in this study. It is demonstrated that the presence of natural geological discontinuities and the mining-induced stress field play an important role in determining the extent and pattern of fracture propagation. Analysis of the mining-induced explicit fracturing system in the vicinity of valley provides an improved understanding of the near-surface hydrological cycle and enables effective remediation of the mining-induced adverse impacts on river valleys.
Integration of metabolomics, transcriptomics, and microRNA Integration of metabolomics, transcriptomics, and microRNA expression profiling reveals a miR-143-HK2-glucose network expression profiling reveals a miR-143-HK2-glucose network underlying zinc-deficiency-associated esophageal neoplasia under

Esophageal squamous cell carcinoma (ESCC) in humans is a deadly disease associated with dietary zinc (Zn)-deficiency. In the rat esophagus, Zn-deficiency induces cell proliferation, alters mRNA and microRNA gene expression, and promotes ESCC. We investigated whether Zn-deficiency alters cell metabolism by evaluating metabolomic profiles of esophageal epithelia from Zn-deficient and replenished rats vs sufficient rats, using untargeted gas chromatography time-of-flight mass spectrometry ( n = 8/group). The Zn-deficient proliferative esophagus exhibits a distinct metabolic profile with glucose down 153-fold and lactic acid up 1.7-fold ( P < 0.0001), indicating aerobic glycolysis (the “Warburg effect”), a hallmark of cancer cells. Zn-replenishment rapidly increases glucose content, restores deregulated metabolites to control levels, and reverses the hyperplastic phenotype. Integration of metabolomics and our reported transcriptomic data for this tissue unveils a link between glucose down-regulation and overexpression of HK2, an enzyme that catalyzes the first step of glycolysis and is overexpressed in cancer cells. Searching our published microRNA profile, we find that the tumor-suppressor miR-143, a negative regulator of HK2, is down-regulated in Zn-deficient esophagus. Using in situ hybridization and immunohistochemical analysis, the inverse correlation between miR-143 down-regulation and HK2 overexpression is documented in hyperplastic Zn-deficient esophagus, archived ESCC-bearing Zn-deficient esophagus, and human ESCC tissues. Thus, to sustain uncontrolled cell proliferation, Zn-deficiency reprograms glucose metabolism by modulating expression of miR-143 and its target HK2. Our work provides new insight into critical roles of Zn in ESCC development and prevention.
Adaptation of Language Resources and Tools for Closely Related Languages and Language Variants Proceedings of the Adaptation of Language Resources and Tools for Closely Related Languages and Language Variants associated

In this paper we describe the construction of a parallel corpus between the standard and a non-standard language variety, specifically standard Austrian German and Viennese dialect. The resulting parallel corpus is used for statistical machine translation (SMT) from the standard to the non-standard variety. The main challenges to our task are data scarcity and the lack of an authoritative orthography. We started with the generation of a base corpus of manually transcribed and translated data from spoken text encoded in a specifically developed orthography. This data is used to train a first phrasebased SMT. To deal with out-of-vocabulary items we exploit the strong proximity between source and target variety with a backoff strategy that uses character-level models. To arrive at the necessary size for a corpus to be used for SMT, we employ a boot-strapping approach. Integrating additional available sources (comparable corpora, such as Wikipedia) necessitates to identify parallel sentences out of substantially differing parallel documents. As an additional task, the spelling of the texts has to be transformed into the above mentioned orthography of the target variety.
Depression And Spiritual Well-Being of Hemodialysis Patients: A Sectional Study

Aim : This study was designed to determine the relationship between depression and spirituality in hemodialysis patients in a dialysis center. Material and Method : The research is in the type of descriptive research. The current study was conducted with 74 patients hemodialysis. The data of the study was collected by applying “Personal Information Form”, “Beck Depression Inventory” and “Spiritual Well-Being Scale”. The data were collected face to face using the questionnaire method. In the analysis of the data, descriptive statistics, t-test, Anova test and correlation analysis were used. Results : More than half of the patients were 51 years and over (54.1%) and 60.8% were male. When the Beck Depression Inventory's scores were analyzed according to the cut-off point, it was found that 58.1% of the patients showed depressive symptoms. In the study, BDI mean score was 19.27±7.31, SWBS mean score was 18.74±10.8 (Subscales: Peace 5.70±3.52, Meaning 6.27±3.67, Faith 6.75±3.97). The results of this study revealed that there is a negative significant relationship between mental well-being and depression (p<0.05). Conclusion : As the moral well-being level of patients receiving hemodialysis treatment increases, their depressive symptoms decrease. Therefore, assessing spiritual health and integrating spiritual care into daily practice can help improve the quality of care and achieve better health outcomes.
con-Effects of early exercise on metacarpophalangeal joints in horses

Objective —To determine the effects of exercise at an early age on tissues in the metacar-pophalangeal joints of horses. Animals —Twelve 18-month-old horses. Procedures —All horses were pasture reared, but 6 horses had additional exercise starting at 3 weeks of age until 18 months of age. At that time, computed tomography, articular cartilage metabolism evaluation, and histologic assessments of synovial membrane, articular cartilage, and subchondral bone were performed. Results —Exercised horses had fewer gross lesions, less articular cartilage matrix staining in the dorsal aspect of the condyle, greater bone fraction in the dorsolateral aspect of the condyle, and higher bone formation rate, compared with nonexercised horses. Conclusions and Clinical Relevance —Exercise at a young age may be protective to joints, although more research is needed to characterize changes in articular cartilage matrix. Results suggested that exercise can be safely imposed at an early age. ( Am J Vet Res 2010;71:405–411)
Digital Commons @ New Haven Digital Commons @ New Haven

Background: Inteins and introns are genetic elements that are removed from proteins and RNA after translation or transcription, respectively. Previous studies have suggested that these genetic elements are found in conserved parts of the host protein. To our knowledge this type of analysis has not been done for group II introns residing within a gene. Here we provide quantitative statistical support from an analyses of proteins that host inteins, group I introns, group II introns and spliceosomal introns across all three domains of life. Results: To determine whether or not inteins, group I, group II, and spliceosomal introns are found preferentially in conserved regions of their respective host protein, conservation profiles were generated and intein and intron positions were mapped to the profiles. Fisher's combined probability test was used to determine the significance of the distribution of insertion sites across the conservation profile for each protein. For a subset of studied proteins, the conservation profile and insertion positions were mapped to protein structures to determine if the insertion sites correlate to regions of functional activity. All inteins and most group I introns were found to be preferentially located within conserved regions; in contrast, a bacterial intein-like protein, group II and spliceosomal introns did not show a preference for conserved sites. Conclusions: These findings demonstrate that inteins and group I introns are found preferentially in conserved regions of their respective host proteins. Homing endonucleases are often located within inteins and group I introns and these may facilitate mobility to conserved regions. Insertion at these conserved positions decreases the chance of elimination, and slows deletion of the elements, since removal of the elements has to be precise as not to disrupt the function of the protein. Furthermore, functional constrains on the targeted site make it more difficult for hosts to evolve immunity to the homing endonuclease. Therefore, these elements will better survive and propagate as molecular parasites in conserved sites. In contrast, spliceosomal introns and group II introns do not show significant preference for conserved sites and appear to have adopted a different strategy to evade loss
Reading Emotions in the Digital Age: A Deep Learning Approach to Detecting Anxiety During the COVID-19 Pandemic through Social Media

During an unprecedented crisis, such as the COVID-19 pandemic, people respond to increased uncertainty in their social surroundings, which often entails various emotional expressions, including fear and frustration. Anxiety is particularly important because it may serve as a symptomatic indicator of various social problems, such as the collapse of trust, polarized public opinions
Automatic Verification of Cryptographic Protocols : A Logic Programming Approach

We present a technique for cryptographic protocol verification, based on an intermediate representation of the protocol by a set of Horn clauses (a logic program). This technique makes it possible to verify security properties of the protocols, such as secrecy and authenticity, in a fully automatic way. Furthermore, the obtained security proofs are valid for an unbounded number of sessions of the protocol.