Miracle-dz/UniFAR-FTUs huggingface dataset:
Project to Strengthen Pancasila Student Profile as an Application of Differentiated Learning in the Independent Curriculum: A Case Study at a Senior High School in Pandeglang, Indonesia

This study aimed to determine the implementation of project to strengthen Pancasila student profile activities as a project to strengthen the profile of Pancasila students at a senior high school in pandeglang district, indonesia, as well as the impact of its implementation on students. The procedure used in this study is a qualitative method with a descriptive approach. The data collection methods used are interviews and questionnaires. The interview was conducted with seven respondents, namely teachers at a senior high school in pandeglang district, indonesia, who are facilitators in implementing an independent curriculum in the classroom, as well as class X and XI students as participants in project to strengthen Pancasila student profile activities. Students are required to make or do a project to implement an independent curriculum. Project activities in this independent curriculum, one of which is by carrying out project to strengthen Pancasila student profile activities. The project to strengthen Pancasila student profile activity is a project to strengthen Pancasila students' profiles. The project to strengthen Pancasila student profile activities were adjusted to the seven themes arranged by the Indonesian Ministry of Education, Culture, Research, and Technology. The project results to be displayed in the project to strengthen Pancasila student profile project exhibition at a senior high school in pandeglang district, indonesia, include (1) Posters; (2) A bulletin board; (3) Democracy pocketbook; (4) A best practice anti-bullying. A senior high school in pandeglang district, indonesia, is included in the activator school with activator teachers, making differentiated learning a strategy in the activator teacher program activities.
Toxicomethylomics revisited: A state-of-the-science review about DNA methylation modifications in blood cells from workers exposed to toxic agents

Introduction Epigenetic marks have been proposed as early changes, at the subcellular level, in disease development. To find more specific biomarkers of effect in occupational exposures to toxicants, DNA methylation studies in peripheral blood cells have been performed. The goal of this review is to summarize and contrast findings about DNA methylation in blood cells from workers exposed to toxicants. Methods A literature search was performed using PubMed and Web of Science. After first screening, we discarded all studies performed in vitro and in experimental animals, as well as those performed in other cell types other than peripheral blood cells. Results: 116 original research papers met the established criteria, published from 2007 to 2022. The most frequent investigated exposures/labor group were for benzene (18.9%) polycyclic aromatic hydrocarbons (15.5%), particulate matter (10.3%), lead (8.6%), pesticides (7.7%), radiation (4.3%), volatile organic compound mixtures (4.3%), welding fumes (3.4%) chromium (2.5%), toluene (2.5%), firefighters (2.5%), coal (1.7%), hairdressers (1.7%), nanoparticles (1.7%), vinyl chloride (1.7%), and others. Few longitudinal studies have been performed, as well as few of them have explored mitochondrial DNA methylation. Methylation platforms have evolved from analysis in repetitive elements (global methylation), gene-specific promoter methylation, to epigenome-wide studies. The most reported observations were global hypomethylation as well as promoter hypermethylation in exposed groups compared to controls, while methylation at DNA repair/oncogenes genes were the most studied; studies from genome-wide studies detect differentially methylated regions, which could be either hypo or hypermethylated. Discussion Some evidence from longitudinal studies suggest that modifications observed in cross-sectional designs may be transitory; then, we cannot say that DNA methylation changes are predictive of disease development due to those exposures. Conclusion Due to the heterogeneity in the genes studied, and scarcity of longitudinal studies, we are far away from considering DNA methylation changes as biomarkers of effect in occupational exposures, and nor can we establish a clear functional or pathological correlate for those epigenetic modifications associated with the studied exposures.
PERFORMANCE AGRICULTURAL EXTENSION IN ACEH BESAR DISTRICT, ACEH PROVINCE, INDONESIA

This study’s objective is to ascertain how big the level of performance of agricultural instructors, and what are the factors that influence their performance. This research was conducted in Aceh Besar District. The number of samples is 28 people. The method used is descriptive qualitative method and multinomial logistic regression. The results showed that the level of performance of agricultural extension workers at a very perfect level was proven by several activities from the preparation of agricultural extension, extension workers who were in the medium category tended to be high in carrying out extension activities, evaluating and compiling reports on the results of extension activities. By using nine variables (x) in the simultaneous test, the value of the intercept only final variable sig value is 0.000, which means that the independent variable statistically significantly affects the dependent variable because the P-value <α(0.00 < 0.05). For the independent variables that affect the dependent variable, namely Xi1 Age, Xi4 Distance of residence, Xi5 Ownership of communication media, Xii1 Training, Xii2 Affordability of work area, Xii3 Availability of facilities and infrastructure, Xii4 Level of active participation of farmers. The seven independent variables have a significant influence on the independent variables.
Relationship between health literacy and COVID-19 knowledge: A cross-sectional study

Background Health literacy (HL) is a protective factor for some chronic diseases. However, its role in the Coronavirus Disease 2019 (COVID-19) pandemic has not been clarified. This study aims to explore the association between HL and COVID-19 knowledge among residents in Ningbo. Methods A total of 6,336 residents aged 15–69 years in Ningbo were selected by multi-stage stratified random sampling method. The “Health Literacy Questionnaire of Chinese Citizens (2020)” was used to evaluate the relationship between COVID-19 knowledge and HL. Chi-square test, Mann-Whitney U test and logistic regression were used to analyze the data. Results The HL and COVID-19 knowledge levels of Ningbo residents were 24.8% and 15.7%, respectively. After adjusting for confounding factors, people with adequate HL were the more likely to have adequate COVID-19 knowledge compared with those with limited HL (OR = 3.473, 95% CI = 2.974–4.057, P <0.001). Compared with the limited HL group, the adequate HL group had a higher rate of COVID-19 knowledge, a more positive attitude, and a more active behavior. Conclusion COVID-19 knowledge is significantly associated with HL. Improving HL may influence people's knowledge about COVID-19, thereby changing people's behaviors, and finally combating the pandemic.
Mebendazole Treatment Disrupts the Transcriptional Activity of Hypoxia-Inducible Factors 1 and 2 in Breast Cancer Cells

Simple Summary Mebendazole (MBZ), an orally available, FDA-approved anthelmintic, has demonstrated efficacy in reducing solid tumor growth and preventing or treating metastasis in multiple preclinical models of cancer. MBZ was also well tolerated in a recently completed phase I clinical trial. Given the success of MBZ, we aimed to identify additional mechanisms of action for MBZ beyond those that have been previously reported, which include tubulin disruption, inhibiting angiogenesis, promoting apoptosis, and maintaining cell stemness. We demonstrate that MBZ can inhibit the transcriptional activity of HIFs in breast cancer cell lines and in preclinical models of breast cancer by preventing the induction of HIF-1α, HIF-2α, and HIF-1β at the protein level under hypoxic conditions. We show that MBZ treatment has dual use as a chemotherapeutic agent as well as blocking the hypoxia-induced phenotype that promotes chemoresistance. Abstract Breast cancer is the most diagnosed cancer in women in the world. Mebendazole (MBZ) has been demonstrated to have preclinical efficacy across multiple cancers, including glioblastoma multiforme, medulloblastoma, colon, breast, pancreatic, and thyroid cancers. MBZ was also well tolerated in a recent phase I clinical trial of adults diagnosed with glioma. The mechanisms of action reported so far for MBZ include tubulin disruption, inhibiting angiogenesis, promoting apoptosis, and maintaining stemness. To elucidate additional mechanisms of action for mebendazole (MBZ), we performed RNA sequencing of three different breast cancer cell lines treated with either MBZ or vehicle control. We compared the top genes downregulated upon MBZ treatment with expression profiles of cells treated with over 15,000 perturbagens using the clue.io online analysis tool. In addition to tubulin inhibitors, the gene expression profile that correlated most with MBZ treatment matched the profile of cells treated with known hypoxia-inducible factor (HIF-1α and -2α) inhibitors. The HIF pathway is the main driver of the cellular response to hypoxia, which occurs in solid tumors. Preclinical data support using HIF inhibitors in combination with standard of care to treat solid tumors. Therefore, we tested the hypothesis that MBZ could inhibit the hypoxia response. Using RNA sequencing and HIF-reporter assays, we demonstrate that MBZ inhibits the transcriptional activity of HIFs in breast cancer cell lines and in mouse models of breast cancer by preventing the induction of HIF-1α, HIF-2α, and HIF-1β protein under hypoxia. Taken together, our results suggest that MBZ treatment has additional therapeutic efficacy in the setting of hypoxia and warrants further consideration as a cancer therapy.
Hierarchical Tensor Decomposition of Module Partition for the Mechanical Simulation

The mechanical simulation experiment can provide guidelines for the structural design of materials, but the module partition of mechanical simulation experiments is still in its infancy. A mechanical simulation contour, e.g., strain and stress contour, has hierarchical characteristics. By analyzing the contour at different layers, the physical properties of the structure material can be improved. Current state-of-the-art methods cannot distinguish between simulation strain contours, as well as sparsely distributed spots of strain (stress concentrations) from simulation strain contour images, resulting in simulation data that does not accurately reflect real strain contours. In this paper, a Hierarchical Tensor Decomposition (HTD) method is proposed to extract hierarchical contours and stress concentrations from the simulation strain contours and then improve the mechanical simulation. HTD decomposes a tensor into three classes of components: the multi-smooth layers, the sparse spots layer, and the noise layer. The number of multismooth layers is determined by the scree plot, which is the difference between the smooth layers and the sparse spots layer. The proposed method is validated by several numerical examples, which demonstrate its effectiveness and efficiency. A further benefit of the module partition is the improvement of the mechanical structural properties.
Newfangled Topical Film-Forming Solution for Facilitated Antifungal Therapy: Design, Development, Characterization, and In Vitro Evaluation

Luliconazole is a broad-spectrum topical antifungal agent that acts by altering the synthesis of fungi cell membranes. Literature suggests that the recurrence of fungal infection can be avoided by altering the pH of the site of infection. Studies have also suggested that fungi thrive by altering skin pH to be slightly acidic, i.e., pH 3–5. The current study is aimed to design, develop, characterize, and evaluate an alkaline pH-based antifungal spray solution for antifungal effects. Luliconazole was used as an antifungal agent and an alkaline spray was formulated for topical application by using Eudragit RS 100, propylene glycol (PG), water, sodium bicarbonate, and ethanol via solubilization method. Herein, sodium bicarbonate was used as an alkalizing agent. Based on DSC, FTIR, PXRD, scanning electron microscopy (SEM), and rheological analysis outcomes, the drug (luliconazole) and polymer were found to be compatible. F-14 formulation containing 22% Eudragit RS 100 (ERS), 1.5% PG, and 0.25% sodium bicarbonate was optimized by adopting the quality by design approach by using design of experiment software. The viscosity, pH, drying time, volume of solution post spraying, and spray angle were, 14.99 ± 0.21 cp, 8 pH, 60 s, 0.25 mL ± 0.05 mL, and 80 ± 2, respectively. In vitro drug diffusion studies and in vitro antifungal trials against Candida albicans revealed 98.0 ± 0.2% drug diffusion with a zone of inhibition of 9 ± 0.12 mm. The findings of the optimized luliconazole topical film-forming solution were satisfactory, it was compatible with human skin, and depicted sustained drug release that suggests promising applicability in facilitated topical antifungal treatments.
Construction of the Superconducting ECR Ion Source Venus

A new, very high magnetic field superconducting ECR ion source, VENUS, is under development at the LBNL 88-Inch Cyclotron. It will boost the maximum energies and intensities for heavy ions from the cyclotron particularly for ions with mass greater than 60. It will also serve as R&D ion source for the proposed Rare Isotope Accelerator (RIA) project in the US, which requires up to 10 pµA of U30+. The superconducting magnet structure consists of three solenoids and six racetrack coils with iron poles forming the sextupole. The coils are designed to generate a 4 T axial mirror field at injection and 3 T at extraction and a radial sextupole field of 2.4 T at the plasma chamber wall. Test results of the magnet coils, which exceeded design requirements with minimum training, are presented. The magnet assembly with its cryostat will be enclosed by an iron shield and therefore must be designed to withstand any possible forces between coils and iron, which can be as high as 3.4 · 105 N (35,000 kgf). The low energy beam transport line (LEBT) and mass analyzing system of the ion source is designed to transport a proton- equivalent current of 25 mA at 20 kV extraction voltage. The design of the ion source and LEBT will be discussed.
Molecular Screening of Bioactive Compounds of Garlic for Therapeutic Effects against COVID-19

An outbreak of pneumonia occurred on December 2019 in Wuhan, China, which caused a serious public health emergency by spreading around the globe. Globally, natural products are being focused on more than synthetic ones. So, keeping that in view, the current study was conducted to discover potential antiviral compounds from Allium sativum. Twenty-five phytocompounds of this plant were selected from the literature and databases including 3-(Allylsulphinyl)-L-alanine, Allicin, Diallyl sulfide, Diallyl disulfide, Diallyl trisulfide, Glutathione, L-Cysteine, S-allyl-mercapto-glutathione, Quercetin, Myricetin, Thiocysteine, Gamma-glutamyl-Lcysteine, Gamma-glutamylallyl-cysteine, Fructan, Lauricacid, Linoleicacid, Allixin, Ajoene, Diazinon Kaempferol, Levamisole, Caffeicacid, Ethyl linoleate, Scutellarein, and S-allylcysteine methyl-ester. Virtual screening of these selected ligands was carried out against drug target 3CL protease by CB-dock. Pharmacokinetic and pharmacodynamic properties defined the final destiny of compounds as drug or non-drug molecules. The best five compounds screened were Allicin, Diallyl Sulfide, Diallyl Disulfide, Diallyl Trisulfide, Ajoene, and Levamisole, which showed themselves as hit compounds. Further refining by screening filters represented Levamisole as a lead compound. All the interaction visualization analysis studies were performed using the PyMol molecular visualization tool and LigPlot+. Conclusively, Levamisole was screened as a likely antiviral compound which might be a drug candidate to treat SARS-CoV-2 in the future. Nevertheless, further research needs to be carried out to study their potential medicinal use.
Application of an Intraoperative Limb Positioner for Adjustable Traction in Both-Column Fractures of the Acetabulum: A Technical Note with Clinical Outcome

Traction of the ipsilateral leg is usually required to facilitate fracture reduction while operating both-column acetabular fractures. However, it is challenging to maintain constant traction manually during the operation. Herein, we surgically treated such injuries while maintaining traction using an intraoperative limb positioner and investigated the outcomes. This study included 19 patients with both-column acetabular fractures. Surgery was performed after the patient’s condition had stabilized, at an average of 10.4 days after injury. The Steinmann pin was transfixed to the distal femur and connected to a traction stirrup; subsequently, the construct was affixed to the limb positioner. A manual traction force was applied through the stirrup and maintained with the limb positioner. Using a modified Stoppa approach combined with the lateral window of the ilioinguinal approach, the fracture was reduced, and plates were applied. Primary union was achieved in all cases at an average of 17.3 weeks. The quality of reduction at the final follow-up was found to be excellent, good, and poor in 10, 8, and 1 patients, respectively. The average Merle d’Aubigné score at the final follow-up was 16.6. Surgical treatment of both-column acetabular fracture using intraoperative traction with a limb positioner yields satisfactory radiological and clinical outcomes.
Analysis of 16S rRNA Gene Sequence of Nasopharyngeal Exudate Reveals Changes in Key Microbial Communities Associated with Aging

Functional or compositional perturbations of the microbiome can occur at different sites, of the body and this dysbiosis has been linked to various diseases. Changes in the nasopharyngeal microbiome are associated to patient’s susceptibility to multiple viral infections, supporting the idea that the nasopharynx may be playing an important role in health and disease. Most studies on the nasopharyngeal microbiome have focused on a specific period in the lifespan, such as infancy or the old age, or have other limitations such as low sample size. Therefore, detailed studies analyzing the age- and sex-associated changes in the nasopharyngeal microbiome of healthy people across their whole life are essential to understand the relevance of the nasopharynx in the pathogenesis of multiple diseases, particularly viral infections. One hundred twenty nasopharyngeal samples from healthy subjects of all ages and both sexes were analyzed by 16S rRNA sequencing. Nasopharyngeal bacterial alpha diversity did not vary in any case between age or sex groups. Proteobacteria, Firmicutes, Actinobacteria, and Bacteroidetes were the predominant phyla in all the age groups, with several sex-associated. Acinetobacter, Brevundimonas, Dolosigranulum, Finegoldia, Haemophilus, Leptotrichia, Moraxella, Peptoniphilus, Pseudomonas, Rothia, and Staphylococcus were the only 11 bacterial genera that presented significant age-associated differences. Other bacterial genera such as Anaerococcus, Burkholderia, Campylobacter, Delftia, Prevotella, Neisseria, Propionibacterium, Streptococcus, Ralstonia, Sphingomonas, and Corynebacterium appeared in the population with a very high frequency, suggesting that their presence might be biologically relevant. Therefore, in contrast to other anatomical areas such as the gut, bacterial diversity in the nasopharynx of healthy subjects remains stable and resistant to perturbations throughout the whole life and in both sexes. Age-associated abundance changes were observed at phylum, family, and genus levels, as well as several sex-associated changes probably due to the different levels of sex hormones present in both sexes at certain ages. Our results provide a complete and valuable dataset that will be useful for future research aiming for studying the relationship between changes in the nasopharyngeal microbiome and susceptibility to or severity of multiple diseases.
Numerical Analysis of Curing Residual Stress and Strain in NEPE Propellant Grain

In order to investigate the formation mechanism of the residual stress and residual strain in a nitrate ester plasticized polyether (NEPE) propellant grain during the curing and cooling process, the temperature, curing degree and stress/strain of the NEPE propellant grain during the curing and cooling process were analyzed via ABAQUS finite element software. The results indicate that there is a temperature gradient in the NEPE propellant grain during curing at 50 °C. The maximum temperature difference is about 5 °C and the maximum temperature is located on the center of propellant grain. At the end of curing, the temperature in the interior of the grain tends to be uniform. The curing degree in the NEPE propellant grain during the curing process has the same trend as temperature. The residual stress/strain of the NEPE propellant grain during the curing and cooling down processes are mainly composed of curing shrinkage stress/strain in the curing process and thermal stress/strain in the cooling down process. The curing shrinkage stress and strain in the curing process account for 19% and 31% of the whole process, respectively. The thermal stress and thermal strain in cooling down process account for 75% and 69% of the whole process, respectively. The thermal stress and thermal strain in the curing process can nearly be ignored. The residual stress and residual strain calculated by the traditional method is larger than that obtained in this paper. The maximum deviation of the residual stress and residual strain are about 8% and 17%, respectively.
The Generalized Gilbert-Varshamov Bound is Implied by TurTheorem

The generalization of the Gilbert-Varshamov bound due to Gu and Fuja is a direct consequence of Turtheorem on the existence of a clique in a graph with many edges. Tur ´ an's theorem allows a slight improvement of Gu and Fuja's result. This improved generalized Gilbert-Varshamov bound is in fact equivalent to Turtheorem.
On the Feasibility of Monitoring Power Transformer’s Winding Vibration and Temperature along with Moisture in Oil Using Optical Sensors

Despite major progress in the design of power transformers, the Achilles’ heel remains the insulation system, which is affected by various parameters including moisture, heat, and vibrations. These important machines require extreme reliability to guarantee electricity distribution to end users. In this contribution, a fiber optic sensor (FOS), consisting of a Fabry–Perot cavity made up of two identical fiber Bragg gratings (FBGs), is proposed, to monitor the temperature and vibration of power transformer windings. A phase shifted gratings recoated sensor, with multilayers of polyimide films, is used to monitor the moisture content in oil. The feasibility is investigated using an experimental laboratory transformer model, especially fabricated for this application. The moisture contents are well correlated with those measured by a Karl Fisher titrator, while the values of temperature compare well with those recorded from thermocouples. It is also shown that the sensors can be used to concurrently detect vibration, as assessed by sensitivity to the loading current. The possibility of dynamically measuring humidity, vibrations, and temperatures right next to the winding, appears to be a new insight that was previously unavailable. This approach, with its triple ability, can help to reduce the required number of sensors and therefore simplify the wiring layout.