Miracle-dz/UniFAR-FTUs huggingface dataset:
Mapping parallelism to multi-cores: a machine learning based approach

The efficient mapping of program parallelism to multi-core processors is highly dependent on the underlying architecture. This paper proposes a portable and automatic compiler-based approach to mapping such parallelism using machine learning. It develops two predictors: a data sensitive and a data insensitive predictor to select the best mapping for parallel programs. They predict the number of threads and the scheduling policy for any given program using a model learnt off-line. By using low-cost profiling runs, they predict the mapping for a new unseen program across multiple input data sets. We evaluate our approach by selecting parallelism mapping configurations for OpenMP programs on two representative but different multi-core platforms (the Intel Xeon and the Cell processors). Performance of our technique is stable across programs and architectures. On average, it delivers above 96% performance of the maximum available on both platforms. It achieve, on average, a 37% (up to 17.5 times) performance improvement over the OpenMP runtime default scheme on the Cell platform. Compared to two recent prediction models, our predictors achieve better performance with a significant lower profiling cost.
A motif in the C-terminal domain of ϕC31 integrase controls the directionality of recombination

Bacteriophage ϕC31 encodes an integrase, which acts on the phage and host attachment sites, attP and attB, to form an integrated prophage flanked by attL and attR. In the absence of accessory factors, ϕC31 integrase cannot catalyse attL x attR recombination to excise the prophage. To understand the mechanism of directionality, mutant integrases were characterized that were active in excision. A hyperactive integrase, Int E449K, gained the ability to catalyse attL x attR, attL x attL and attR x attR recombination whilst retaining the ability to recombine attP x attB. A catalytically defective derivative of this mutant, Int S12A, E449K, could form stable complexes with attP/attB, attL/attR, attL/attL and attR/attR under conditions where Int S12A only complexed with attP/attB. Further analysis of the Int E449K-attL/attR synaptic events revealed a preference for one of the two predicted synapse structures with different orientations of the attL/attR sites. Several amino acid substitutions conferring hyperactivity, including E449K, were localized to one face of a predicted coiled-coil motif in the C-terminal domain. This work shows that a motif in the C-terminal domain of ϕC31 integrase controls the formation of the synaptic interface in both integration and excision, possibly through a direct role in protein–protein interactions.
Proposal of recovery strategy from loss of leg incident for legged walking robot

In this paper author gives an overview of locomotion strategy based on the idea of using virtual leading edges for movement calculations of a multi-legged robot, of symmetrical construction and proposes the idea of using locomotion strategy for recovery from loss of leg incident by reconfiguring the robot to resemble legged mechanisms with lesser number of legs and applying virtual leading edges locomotion strategy to a new configuration. Presented locomotion strategy can be used for energy-efficient robot with low power processors. The method is fast and the computational cost is low.
Dose Escalation Safety and Tolerance Study of the Competitive NMDA Antagonist Selfotel (CGS 19755) in Neurosurgery Patients

Selfotel (CGS 19755), a competitivey N-methyl-D-aspartate antagonist, is neuroprotective in experimental models of ischemic cerebral injury. We studied the safety and tolerability of a single intravenous dose (0.5 to 2.0 mg/kg) of selfotel in neurosurgery patients. Thirty-two neurosurgical patients undergoing intracranial surgery were given ascending doses of selfotel 2 to 14 h before surgery. Serum selfotel levels were measured over a period of 24 h. Cerebrospinal fluid (CSF) levels were measured 1.5 to 18 h after dosing. Frequent side effects included psychomimetic symptoms such as hallucinations, abnormal dreaming, agitation, and paranoia among 20 (66%) patients. Ataxia was seen among five (16%) and dizziness among eight (25%). Symptoms occurred 38 min to 40 h from administration and persisted 5 min to 4 days. Symptom severity worsened with increasing area under the curve measurements and doses above 1.0 mg/kg. All symptoms were reversible and easily treated with intravenous haloperidol. Modest elevations of hepatic enzymes were observed among four patients. No patient had severe adverse reactions. Maximum selfotel levels attained were 143 μmol (serum) and 4.76 umol (CSF). Peak serum levels among six patients were within potentially neuroprotective ranges. CSF levels remained detectable up to 18 h after dosing. No obvious relationship was seen between CSF drug levels and symptoms. Selfotel in doses of 0.5 to 2.0 mg/kg can be administered safely to neurosurgical patients. Maximum serum levels attained were within the range shown to be neuroprotective in experimental studies. Side effects even at the highest levels are tolerable and reversible. Selfotel use in patients at risk for cerebral injury should be further explored.
Toward a Diminished Role for Tort Liability: Social Insurance, Government Regulation, and Contemporary Risks to Health and Safety

Society approaches health and safety risks in a piecemeal fashion. Regulators attempt to control the risks in their domain as if regulations were the only factor preventing injuries at home, in the workplace, and on the highways. Similarly, the courts address accidents with rules that not only discourage, but sometimes also forbid, consideration of norms and institutions outside the tort system. Academic commentators share this blind spot, focusing on only one method of managing risks and recommending, for example, an optimal tort liability structure' or an appropriate level of stringency for an administrative regulation.2 These methods and analyses are valuable, but they do not consider the complexities arising from the overlap of market forces, tort law, social insurance, and government regulation. ' Each of these institutions influences the management of risks in important ways. And each has effects that, when combined, create dissonance between risks and societal responses. Without coordination of these risk-reduction systems, society will rarely invest optimally.to achieve the goals of creating efficient incentives and providing appropriate compensation to injured parties. Further, even if society is not overor under-responsive to risks as a whole, it may
B Cell Epitope-Based Vaccination Therapy

Currently, many peptide vaccines are undergoing clinical studies. Most of these vaccines were developed to activate cytotoxic T cells; however, the response is not robust. Unlike vaccines, anti-cancer antibodies based on passive immunity have been approved as a standard treatment. Since passive immunity is more effective in tumor treatment, the evidence suggests that limited B cell epitope-based peptide vaccines may have similar activity. Nevertheless, such peptide vaccines have not been intensively developed primarily because humoral immunity is thought to be preferable to cancer progression. B cells secrete cytokines, which suppress immune functions. This review discusses the possibility of therapeutic antibody induction by a peptide vaccine and the role of active and passive B cell immunity in cancer patients. We also discuss the use of humanized mice as a pre-clinical model. The necessity of a better understanding of the activity of B cells in cancer is also discussed.
The Faculty Costs to Educate a Biomedical Sciences Graduate Student

Given the demands of a responsibility centers management fiscal model at the Medical University of South Carolina, a survey was designed to estimate the faculty costs of educating a biomedical sciences graduate student. The survey offers a readily applicable model for empirical estimation of faculty salary costs when developing budgets that will sustain a graduate school’s commitment to its teaching, research, and service mission goals.
Beyond cAMP: The Regulation of Akt and GSK3 by Dopamine Receptors

Brain dopamine receptors have been preferred targets for numerous pharmacological compounds developed for the treatment of various neuropsychiatric disorders. Recent discovery that D2 dopamine receptors, in addition to cAMP pathways, can engage also in Akt/GSK3 signaling cascade provided a new framework to understand intracellular signaling mechanisms involved in dopamine-related behaviors and pathologies. Here we review a recent progress in understanding the role of Akt, GSK3, and related signaling molecules in dopamine receptor signaling and functions. Particularly, we focus on the molecular mechanisms involved, interacting partners, role of these signaling events in the action of antipsychotics, psychostimulants, and antidepressants as well as involvement in pathophysiology of schizophrenia, bipolar disorder, and Parkinson’s disease. Further understanding of the role of Akt/GSK3 signaling in dopamine receptor functions could provide novel targets for pharmacological interventions in dopamine-related disorders.
Impaired macrophage activation in vitamin D3 deficiency: differential in vitro effects of 1,25-dihydroxyvitamin D3 on mouse peritoneal macrophage functions.

1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) is known to interact in vitro with mononuclear phagocytes. The purpose of this study was to determine the role of the steroid in macrophage activation in vivo. Peritoneal macrophages from normal and vitamin D3-deficient mice were obtained after i.p. injection of activating or eliciting agents. Cells obtained from vitamin D3-deficient mice exhibited defected capabilities to perform anti-tumor activities (cytostasis and cytolysis) and to form oxygen reduction products (H2O2 and O2-). On the other hand, the level of the lysosomal enzyme acid phosphatase was unaffected by vitamin D3 deficiency. In vitro, incubation of macrophages with 1,25(OH)2D3 enhanced their anti-tumor activities, but did not affect the cells' capacity to produce H2O2 and O2-, or acid phosphatase. Our results suggest that 1,25(OH)2D3 is essential for macrophage activation in vivo. However, in vitro, the hormone is only partially capable of affecting the macrophage functions, probably because of the maturation state of the cells.
Hypertrophic osteoarthropathy. Relief of symptoms by vagotomy in a patienh qihh pulmonary metastases from a lympho-epithelioma of the nasopharynx.

CLUBBING OF THE FINGEBS has been known since Hippocrates described curved nails in patients with empyema. In 1889 and 1890, Bamberger and Marie independently clarified the entity of hypertrophie osteoarthropathy, and in 1915 Locke linked it with clubbing as a disease entity. The pathologic features have been well described. Although the etiology is still not clear, a recent theory holds that ischemic lung may effect bone and soft-tissue changes by afferent impulses mediated by the vagus nerve. These impulses result in increased peripheral blood flow, peripheral arteriovenous aneurysms, and the clinical and roentgenologic findings of clubbing and hypertrophie osteoarthropathy. The theory of a vagal reflex mechanism is strongly supported by the fact that the symptoms can be dramatically relieved by intrathoracic or cervical vagotomy. The following is an example of a patient treated in this manner. Report of a Case A 17-year-old male was seen in February, 1959, with the
Bayley's Infant Behavior Record Ratings of Infants with Recurrent Apnea: Behavioral Profile and Correlates with Apnea, Age, and Developmental Status

The goal of this study was to provide a behavioral profile of apneic infants and to examine relationships between behavioral ratings, apnea frequency, age, and concurrent developmental status. Two samples of previously apneic infants were included in this exploratory analysis using the Infant Behavior Record (IBR) as a measure of temperament. Frequency of IBR suspect ratings was more than twice those reported for the Bayley standardization sample for tension, object orientation, attention, and reactivity. Apnea frequency, age, and developmental status were significantly related to a number of IBR ratings with relationships remaining significant for apnea and decreased responsiveness to persons and sensory interest after controlling for age and developmental status in the combined samples. These findings are consistent with a behavioral profile described as a lethargic temperament but may reflect early physiologic instability rather than inherent behavioral style. J Dev Behav Pediatr 13:158–164, 1992. Index terms: apnea, temperament, development.
Plantar fasciitis

INTRODUCTION In this article we look at the aetiology of plantar fasciitis, the other common differentials for heel pain and the evidence available to support each of the major management options. We also review the literature and discuss the condition. METHODS A literature search was performed using PubMed and MEDLINE®. The following keywords were used, singly or in combination: ‘plantar fasciitis’, ‘plantar heel pain’, ‘heel spur’. To maximise the search, backward chaining of reference lists from retrieved papers was also undertaken. FINDINGS Plantar fasciitis is a common and often disabling condition. Because the natural history of plantar fasciitis is not understood, it is difficult to distinguish between those patients who recover spontaneously and those who respond to formal treatment. Surgical release of the plantar fascia is effective in the small proportion of patients who do not respond to conservative measures. New techniques such as endoscopic plantar release and extracorporeal shockwave therapy may have a role but the limited availability of equipment and skills means that most patients will continue to be treated by more traditional techniques.
Automatic layout of project plans using a metro map metaphor

In this paper, we describe a tool to improve inter-functional communication of project plans by displaying them as a metro map. Our tool automatically lays out plans using a multicriteria system adapted for the application area. Previous studies have shown that displaying project plans using a metro map metaphor as a complementary visualization to Gantt charts attracts and engages individuals, presents an overview of detail and initiates discussions. Creating such a map manually is time consuming. Hence, we have developed a software tool that converts a standard planning format into a metro map visualization and assists designers in generating comprehensible layouts. Our findings may be important for researchers in the domain of human computer interaction, project managers, knowledge visualization and communication scientists.
Intraspecific variation buffers projected climate change impacts on Pinus contorta

Species distribution modeling (SDM) is an important tool to assess the impact of global environmental change. Many species exhibit ecologically relevant intraspecific variation, and few studies have analyzed its relevance for SDM. Here, we compared three SDM techniques for the highly variable species Pinus contorta. First, applying a conventional SDM approach, we used MaxEnt to model the subject as a single species (species model), based on presence–absence observations. Second, we used MaxEnt to model each of the three most prevalent subspecies independently and combined their projected distributions (subspecies model). Finally, we used a universal growth transfer function (UTF), an approach to incorporate intraspecific variation utilizing provenance trial tree growth data. Different model approaches performed similarly when predicting current distributions. MaxEnt model discrimination was greater (AUC – species model: 0.94, subspecies model: 0.95, UTF: 0.89), but the UTF was better calibrated (slope and bias – species model: 1.31 and −0.58, subspecies model: 1.44 and −0.43, UTF: 1.01 and 0.04, respectively). Contrastingly, for future climatic conditions, projections of lodgepole pine habitat suitability diverged. In particular, when the species' intraspecific variability was acknowledged, the species was projected to better tolerate climatic change as related to suitable habitat without migration (subspecies model: 26% habitat loss or UTF: 24% habitat loss vs. species model: 60% habitat loss), and given unlimited migration may increase amount of suitable habitat (subspecies model: 8% habitat gain or UTF: 12% habitat gain vs. species model: 51% habitat loss) in the climatic period 2070–2100 (SRES A2 scenario, HADCM3). We conclude that models derived from within-species data produce different and better projections, and coincide with ecological theory. Furthermore, we conclude that intraspecific variation may buffer against adverse effects of climate change. A key future research challenge lies in assessing the extent to which species can utilize intraspecific variation under rapid environmental change.
Stock Market Prediction with Big Data Through Hybridization of Data Mining and Optimized Neural Network Techniques

The stock market is non-linear in nature, making forecasting a very complicated, challenging and uncertain process. Employing traditional methods may not ensure the reliability of stock prediction. In this paper, we have applied both data mining and optimized neural network in stock prediction with big data. Data mining allows for useful information to be extracted from a huge data set whilst neural network is capable in predicting future trends from large databases; the hybridization of both these techniques can therefore achieve much reliable and robust prediction. This paper has attempted to make a better prediction result for a complicated stock market. In this research, we have collected data from IT Sector organizations of the Dhaka Stock Exchange, which is an emerging stock market and applied K-means clustering of data mining to select the highly increasing securities, Nonlinear autoregressive neural network technique is applied to predict the stock price. The prediction performance through the hybridization is evaluated and positive performance improvement of prediction is observed which is encouraging for investors.
Determination of DPPH Radical Oxidation Caused by Methanolic Extracts of Some Microalgal Species by Linear Regression Analysis of Spectrophotometric Measurements

The demonstrated modified spectrophotometric method makes use of the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and its specific absorbance properties. The absorbance decreases when the radical is reduced by antioxidants. In contrast to other investigations, the absorbance was measured at a wavelength of 550 nm. This wavelength enabled the measurements of the stable free DPPH radical without interference from microalgal pigments. This approach was applied to methanolic microalgae extracts for two different DPPH concentrations. The changes in absorbance measured vs. the concentration of the methanolic extract resulted in curves with a linear decrease ending in a saturation region. Linear regression analysis of the linear part of DPPH reduction versus extract concentration enabled the determination of the microalgae's methanolic extracts antioxidative potentials which was independent to the employed DPPH concentrations. The resulting slopes showed significant differences (6 - 34 μmol DPPH g−1 extract concentration) between the single different species of microalgae (Anabaena sp., Isochrysis galbana, Phaeodactylum tricornutum, Porphyridium purpureum, Synechocystis sp. PCC6803) in their ability to reduce the DPPH radical. The independency of the signal on the DPPH concentration is a valuable advantage over the determination of the EC50 value.
Embedded antenna design based on zero and pole resonances for wireless sensor modules for applications in advanced greenhouses

This paper presents an embedded antenna design for wireless sensor modules for application in advanced greenhouses. The wireless sensor modules are realized based on the UHF RFID tag plus low-power MCU chip [1]. In the antenna design, resonator models are used to tailor the input impedance of the antenna to satisfy the condition of complex conjugate matching, and hence the maximum power transfer between the RFID tag chip and the antenna. The proposed embedded antenna possesses an open-ended quarter wavelength strip monopole to generate a zero resonance, lowering the real part of the input impedance of the antenna, and a parallel chip capacitor near the feeding terminal to provide a pole resonance, pulling up the imaginary part of the impedance, to achieve conjugate matching to the highly capacitive RFID tag chip, whose input impedance is 18 - j171 Ω. The simulated realized gain of the antenna is -0.26 dBi, and the associated maximum read range is 8 m based on Friis' equation with the maximum EIRP of 4 W.
Neuronal Specificity of Acupuncture Response: A fMRI Study with Electroacupuncture

Recently, neuronal correlates of acupuncture stimulation in human brain have been investigated by functional neuroimaging. The preliminary findings suggest that acupuncture at analgesic points involves the pain-related neuromatrix and may have acupoint-brain correlation. Although multiple models of control stimulations have been applied to address the specificity of the needling effect clinically, their impacts have not been evaluated by functional neuroimaging. With the advantage of objective parameter setting, electroacupuncture (EA) was used in this study to devise three distinct controls for real EA, i.e., mock EA (no stimulation), minimal EA (superficial and light stimulation), and sham EA (same stimulation as real EA) applied at nonmeridian points. Fifteen healthy volunteers received real EA at analgesic point Gallbladder 34 (Yanglinquan), sham EA, and one of either mock EA or minimal EA over the left leg in counter-balanced orders. Multisubject analysis showed that sham EA and real EA both activated the reported distributed pain neuromatrix. However, real EA elicited significantly higher activation than sham EA over the hypothalamus and primary somatosensory-motor cortex and deactivation over the rostral segment of anterior cingulate cortex. In the comparison of minimal EA versus mock EA, minimal EA elicited significantly higher activation over the medial occipital cortex. Single-subject analysis showed that superior temporal gyrus (encompassing the auditory cortex) and medial occipital cortex (encompassing the visual cortex) frequently respond to minimal EA, sham EA, or real EA. We concluded that the hypothalamus-limbic system was significantly modulated by EA at acupoints rather than at nonmeridian points, while visual and auditory cortical activation was not a specific effect of treatment-relevant acupoints and required further investigation of the underlying neurophysiological mechanisms.