Miracle-dz/UniFAR-FTUs huggingface dataset:
EXAMINATION AND EVALUATION OF CRAVING-INDUCTIVE VERBAL CUES AMONG PERSIAN-SPEAKING METHAMPHETAMINE ABUSERS

Objective: Drug craving is the main core feature of drug use and relapse. Methamphetamine is a common stimulant in Iran which evokes severe craving in cue exposure. The major aim of the present study is to design and develop a tool for the measurement of craving induced by verbal cues in methamphetamine abusers. Method: In the first step, 15 abusers identified 133 words that induced craving in them. In the next steps the words were divided into seven clusters (drugs, related items, instruments, places, performances, moods, and individuals), and were then incorporated into a Likert scale questionnaire along with 16 neutral words. The questionnaires were administered to 30 participants who were randomly selected from INCAS clinic based on DSM-IV-TR criteria for methamphetamine dependency. Demographics and methamphetamine abuse profiles were obtained based on ASILite; and the inductive power of the words were evaluated subsequently. Finally, the data were analyzed using SPSS-16 using descriptive statistical methods. Results: The results indicated that the words; methamphetamine, drug, substance, money, glass tube, wallet, pipe, lighter, foil, place of drug purchase, bachelor flat, room of drug use, visiting friends, family argument, sexual arousal, craving, anger, depression, co-abuser, fellow-user and methamphetamine dealer were cues with the highest degree of induction. The list of words was thus prepared. Thereafter, in order to assess attentional bias and drug craving, 24 verbal cues were divided into four six-word groups and were introduced along with two neutral groups for administering in addiction Stroop task and the computer program for assessing attentional bias. Conclusion: Ecologically validated drug craving assessment tasks not only provide research potentials in this field, but can also be used in the design and execution of psychological interventions for “relapse prevention”. In this study, a series of these cues and their potentials were introduced and evaluated.
White collar 2 , a partner in bluelight signal transduction , controlling expression of light-regulated genes in Neurospora crassa candidate for a bluelight photoreceptor in plants been

candidate for a blue-light photoreceptor in plants been H.Linden and G.Macino1 cloned (CRY1; Ahmad and Cashmore, 1993). The CRY1 Dipartimento di Biopatologia Umana, Sezione Biologia Cellulare, protein reveals a close homology to bacterial DNA photolyUniversità di Roma La Sapienza, Viale Regina Elena, 324, ase and was also shown to bind flavin, although its mode of 00161 Roma, Italy action and interacting partners are as yet unknown (Lin 1Corresponding author et al., 1995). Although putative mutants affected in bluelight signal transduction events have been identified in A saturating genetic dissection of ‘blind’ mutants in plants, nothing is yet known about the genes coding for Neurospora crassa has identified a total of two nonthe protein components of the blue-light signalling system redundant loci (wc-1 and wc-2) each of which is (Liscum and Hangarter, 1994). Furthermore, numerous required for blue-light perception/signal transduction. genes coding for DNA-binding proteins have been cloned Previously, we demonstrated that WC1 is a putative in plants, but none of these proteins has been assigned zinc finger transcription factor able to bind specifically unequivocally a function in light-induced transcription to a light-regulated promoter. Here, we present the (Terzaghi and Cashmore, 1995). cloning and characterization of the wc-2 gene. We The fungus Neurospora crassa remains a paradigm for demonstrate using mutation analysis and in vitro DNAmolecular genetic studies on blue-light signal transduction. binding assays that WC2, the second partner of this In contrast to plants, in Neurospora only blue light is light signal transduction system, encodes a functional perceived and has been shown genetically and physiologiczinc finger DNA-binding protein with putative PAS ally to regulate many different developmental processes, dimerization and transcription activation domains. e.g. mycelial carotenogenesis (Harding and Turner, 1981), This molecular genetic dissection of the second of two formation of conidia (Lauter and Russo, 1991) and photocomponents of this light signal transduction system tropism of peritecial beaks (Harding and Melles, 1984). has enabled us to devise a model whereby WC1 and Blue-light-regulated transcription has also been observed WC2 are proposed to interact via homologous PAS for many genes in Neurospora such as the carotenoid domains, bind to promoters of light-regulated genes biosynthesis genes al-1, al-2 and al-3 (Nelson et al., 1989; and activate transcription. As such, this study provides Schmidhauser et al., 1990, 1994), the conidiation genes the first insight into two co-operating partners in bluecon-5 and con-10 (Lauter and Russo, 1991), the circadian light signal transduction in any organism and describes clock gene frequency and the clock-controlled genes ccg-1 the molecular tools with which to dissect this enigand ccg-2 (Loros, 1995). matic process. Several classes of Neurospora mutants have been isolated
Pharmacokinetics of plasma-derived C1-esterase inhibitor after subcutaneous versus intravenous administration in subjects with mild or moderate hereditary angioedema: the PASSION study

Hereditary angioedema (HAE) is a rare disease caused by C1‐esterase inhibitor (C1‐INH) deficiency, characterized by periodic attacks of acute edema affecting subcutaneous (SC) tissues and mucous membranes. Human C1‐INH concentrate given intravenously (IV) is effective and safe, but venous access may be difficult. We compared SC and IV administration of human pasteurized C1‐INH concentrate with respect to pharmacokinetics, pharmacodynamics, and safety.
ION CHANNELS , RECEPTORS AND TRANSPORTERS KV 7 channelopathies

KV7 voltage-gated potassium channels, encoded by the KCNQ gene family, have caught increasing interest of the scientific community for their important physiological roles, which are emphasized by the fact that four of the five so far identified members are related to different hereditary diseases. Furthermore, these channels prove to be attractive pharmacological targets for treating diseases characterized by membrane hyperexcitability. KV7 channels are expressed in brain, heart, thyroid gland, pancreas, inner ear, muscle, stomach, and intestines. They give rise to functionally important potassium currents, reduction of which results in pathologies such as long QT syndrome, diabetes, neonatal epilepsy, neuromyotonia, or progressive deafness. Here, we summarize some key traits of KV7 channels and review how their molecular deficiencies could explain diverse disease phenotypes. We also assess the therapeutic potential of KV7 channels; in particular, how the activation of KV7 channels by the compounds retigabine and R-L3 may be useful for treatment of epilepsy or cardiac arrhythmia.
Coffee intake and risk of obesity, metabolic syndrome and type 2 diabetes: a Mendelian randomization study.

BACKGROUND Coffee is one of the most widely consumed beverages. We tested the hypothesis that genetically high coffee intake is associated with low risk of obesity, metabolic syndrome and type 2 diabetes, and with related components thereof. METHODS We included 93,179 individuals from two large general population cohorts in a Mendelian randomization study. We tested first whether high coffee intake is associated with low risk of obesity, metabolic syndrome and type 2 diabetes, and with related components thereof, in observational analyses; second, whether five genetic variants near the CYP1A1, CYP1A2 and AHR genes are associated with coffee intake; and third, whether the genetic variants are associated with obesity, metabolic syndrome and type 2 diabetes, and with related components thereof. Finally, we tested the genetic association with type 2 diabetes in a meta-analysis including up to 78,021 additional individuals from the DIAGRAM consortium. RESULTS Observationally, high coffee intake was associated with low risk of obesity, metabolic syndrome and type 2 diabetes. Further, high coffee intake was associated with high body mass index, waist circumference, weight, height, systolic/diastolic blood pressure, triglycerides and total cholesterol and with low high-density lipoprotein cholesterol, but not with glucose levels. In genetic analyses, 9-10 vs 0-3 coffee-intake alleles were associated with 29% higher coffee intake. However, genetically derived high coffee intake was not associated convincingly with obesity, metabolic syndrome, type 2 diabetes, body mass index, waist circumference, weight, height, systolic/diastolic blood pressure, triglycerides, total cholesterol, high-density lipoprotein cholesterol or glucose levels. Per-allele meta-analysed odds ratios for type 2 diabetes were 1.01 (0.98-1.04) for AHR rs4410790, 0.98 (0.95-1.01) for AHR rs6968865, 1.01 (0.99-1.03) for CYP1A1/2 rs2470893, 1.01 (0.98-1.03) for CYP1A1/2 rs2472297 and 0.98 (0.95-1.01) for CYP1A1 rs2472299. CONCLUSIONS High coffee intake was associated observationally with low risk of obesity, metabolic syndrome and type 2 diabetes, and was associated observationally with related components thereof, but with no genetic evidence to support corresponding causal relationships.
Incidences between Points and Lines in R^4

We show that the number of incidences between m distinct points and n distinct lines in R<sup>4</sup> is O(2<sup>c√log m</sup>(m<sup>2/5</sup>n<sup>4/5</sup> + m) + m<sup>1/2</sup>n<sup>1/2</sup>q<sup>1/4</sup> + m<sup>2/3</sup>n<sup>1/3</sup>s<sup>1/3</sup> + n), for a suitable absolute constant c, provided that no 2-plane contains more than s input lines, and no hyperplane or quadric contains more than q lines. The bound holds without the extra factor 2<sup>c√log m</sup> when m ≤ n<sup>6/7</sup> or m ≥ n<sup>5/3</sup>. Except for this possible factor, the bound is tight in the worst case. The context of this work is incidence geometry, a topic that has been widely studied for more than three decades, with strong connections to a variety of topics, from range searching in computational geometry to the Kakeya problem in harmonic analysis and geometric measure theory. The area has picked up considerable momentum in the past seven years, following the seminal works of Guth and Katz [12, 13], where the later work solves the point-line incidence problem in three dimensions, using new tools and techniques from algebraic geometry. This work extends their result to four dimensions. In doing so, it had to overcome many new technical hurdles that arise from the higher-dimensional context, by developing and adapting more advanced tools from algebraic geometry.
Influences of an Evangelical Christian Worldview on Women’s Leadership Development

The Problem A recent Pew Research Center report noted that 70.6% of U.S. American adults self-identify as Christian; 25.4% identify themselves as Protestant Evangelical. Historically, the worldview of evangelicals has reflected what Gallagher described as a “hierarchically ordered universe. ” The implications of this worldview on both individuals and organizational cultures add complexities as women navigate the labyrinth of leadership. Such complexities, related to the implied superiority of maleness, call for a review of research related to the leadership experiences of evangelical women, with implications for professional development programs. The Solution Recent research has focused attention on leadership identity development; for women, this process involves addressing “the often fragile process of coming to see oneself, and to be seen by others, as a leader. ” Understanding the worldview of evangelicals can be important if the aspirations and abilities of high-potential women are to be fully tapped. Based on previous grounded theory research as reported by Dahlvig and Longman, this article provides a review of the relevant literature, including a model and conceptual framework for leadership development that recognizes the influence of an evangelical worldview on organizational culture and women’s leadership aspirations and experiences of women. The Stakeholders As a multidisciplinary field, Human Resource Development benefits from exploring emerging leadership development theories, especially theories that take into consideration context, culture, and worldview. This research can be instructive to HRD professionals and others who may benefit from understanding how worldview shapes individuals’ lived experiences.
A Wide-Band Efficient Inductive Transdennal Power and Data Link with Coupling Insensitive Gain

This paper describes a new method of desensitizing the gain of an inductive link to the mutual coupling of its inductors. When the coupling varies due to geometrical misalignments [1] this design method guarantees good efficiency and a large bandwidth. The mathematics for four link combinations are presented, and examples of the link efficiency and bandwidth for one of the combinations are shown and discussed.
Narrative Identity Development for Novice Psychotherapists in Clinical Training

Narrative identity is “the internalized, evolving story of the self that each person crafts to provide his or her life with a sense of purpose and unity” (Adler, 2012, p. 367). This identity is distinct from the broad dispositional traits and the characteristic adaptations for contextualized behaviors. It provides the self with a sense of purpose, meaning, and unity across time and situations (McAdams & Olson, 2010). Researchers have developed ways of measuring innovative moments (IMs), or shifts in narrative identity that occur in psychotherapy. Researchers have also explored narrative identity processing as it seems to occur across the lifespan. This study used qualitative reflective learning methods in an attempt to describe some of the narrative identity processes that may be supported during clinical training in graduate psychology programs. Eight narratives, collected from novice clinicians, revealed innovative moments occurring secondary to clinical training. Primary themes include (a) performance, (b) cultural and racial identity, and (c) emotionality, relatedness, and presence. Implications are discussed. The occurrence of these IMs, their themes, and the implications for clinical training warrant further research and exploration. Running head: NARRATIVE IDENTITY AND CLINICAL TRAINING iv
Adapting EUROMOD for use in a developing country - the case of South Africa and SAMOD

This paper describes the construction of a microsimulation model for South Africa (SAMOD), which is based upon the EUROMOD platform. The paper discusses the need for a new microsimulation model in South Africa, the reasons why EUROMOD was a particularly suitable candidate as a basis for the new model and the challenges encountered in building the model. The intention of this paper is to provide necessary background material on the construction of the model to anyone wishing to work with SAMOD and to record the lessons learned in the model-building process which may be helpful to those considering developing their own microsimulation models in other countries. Particular attention is given to the way that South Africa, as a developing country, raises challenges that have not previously been encountered in the development of EUROMOD.
The deletion of /t, d/ in Hong Kong English

Previous research on /t,d/ deletion, the omission of the final /t/ or /d/ sound in word-final consonant clusters of two or more consonants (e.g. just pronounced as jus), indicates that it is pervasive in many varieties of English, including world Englishes such as Indian English, Singapore English, and Nigerian English. This study examines /t,d/ deletion in Hong Kong English in order to examine whether the finding that it occurs systematically across a wide range of Englishes can be extended to this new English. Conversational data were collected from 36 Hong Kong tertiary students; analysis of the data via both descriptive and inferential statistics found that /t,d/ deletion occurred for all the participants in the study, and was governed by linguistic factors and in particular, grammatical category and following linguistic environment.
Taming velocity and variety simultaneously in big data with stream reasoning: tutorial

Many "big data" applications must tame velocity (processing data in-motion) and variety (processing many different types of data) simultaneously. The research on knowledge representation and reasoning has focused on the variety of data, devising data representation and processing techniques that promote integration and reasoning on available data to extract implicit information. On the other hand, the event and stream processing community has focused on the velocity of data, producing systems that efficiently operate on streams of data on-the-fly according to pre-deployed processing rules or queries. Several recent works explore the synergy between stream processing and reasoning to fully capture the requirements of modern data intensive applications, thus giving birth to the research domain of stream reasoning. This tutorial paper offers an overview of the theoretical and technological achievements in stream reasoning, highlighting the key benefits and limitations of existing approaches, and discussing the open challenges and the opportunities for future research. The paper mainly targets researchers and practitioners in the area of event and stream processing. The paper aims to stimulate the discussion on stream reasoning and to further promote the integration of reasoning techniques within event and stream processing systems in three ways: (i) by presenting an active research domain, where researchers on event and stream processing can apply their expertise; (ii) by discussing techniques and technologies that can help advancing the state of the art in event and stream processing; (iii) by identifying the open problems in the field of stream reasoning, and drawing attention to promising research directions.
Increased expression of hepatocyte nuclear factor 6 stimulates hepatocyte proliferation during mouse liver regeneration.

BACKGROUND & AIMS The hepatocyte nuclear factor 6 (HNF6 or ONECUT-1) protein is a cell-type specific transcription factor that regulates expression of hepatocyte-specific genes. Using hepatocytes for chromatin immunoprecipitation (ChIP) assays, the HNF6 protein was shown to associate with cell cycle regulatory promoters. Here, we examined whether increased levels of HNF6 stimulate hepatocyte proliferation during mouse liver regeneration. METHODS Tail vein injection of adenovirus expressing the HNF6 complementary DNA was used to increase hepatic HNF6 levels during mouse liver regeneration induced by partial hepatectomy, and DNA replication was determined by bromodeoxyuridine incorporation. Cotransfection and ChIP assays were used to determine transcriptional target promoters. RESULTS Elevated expression of HNF6 during mouse liver regeneration causes a significant increase in the number of hepatocytes entering DNA replication (S phase), and mouse hepatoma Hepa1-6 cells diminished for HNF6 levels by small interfering RNA transfection exhibit a 50% reduction in S phase following serum stimulation. This stimulation in hepatocyte S-phase progression was associated with increased expression of the hepatocyte mitogen tumor growth factor alpha and the cell cycle regulators cyclin D1 and Forkhead box m1 (Foxm1) transcription factor. Cotransfection and ChIP assays show that tumor growth factor alpha, cyclin D1, and HNF6 promoter regions are direct transcriptional targets of the HNF6 protein. Coimmunoprecipitation assays with regenerating mouse liver extracts reveal an association between HNF6 and FoxM1 proteins, and cotransfection assays show that HNF6 stimulates Foxm1 transcriptional activity. CONCLUSIONS These mouse liver regeneration studies show that increased HNF6 levels stimulate hepatocyte proliferation through transcriptional induction of cell cycle regulatory genes.
A study on PMIP deployment over EPON

In this paper, we discuss the issues that are needed to consider in proxy mobile IP (PMIP) deployment over Ethernet passive optical network (EPON) architecture. We present two architectures in this paper and discuss their strengths and weaknesses. Our discussion and analysis can help the network operators to deploy PMIP in EPON environment.
Evaluer des compétences : Guide pratique

Les enseignants s'efforcent aujourd'hui de developper des competences chez leurs eleves. Mais comment, dans ce contexte, evaluer leurs acquis en termes de competences ? Qu'est-ce qui differencie une evaluation traditionnelle d'une evaluation des competences ? Comment preparer et corriger une epreuve visant a evaluer les competences ? Faut-il n'evaluer que les competences ou faut-il aussi continuer a evaluer de maniere classique ? Ces questions pratiques sont abordees a travers de nombreux exemples, et un referentiel solide et experimente dans de nombreux pays est propose en parallele. Concu comme un outil d'autoformation, ce guide interessera tant les enseignants de toutes les disciplines que les conseillers pedagogiques, les formateurs ou les chercheurs. Des parcours divers, permettant a chaque utilisateur d'orienter sa lecture selon ses propres objectifs, sont organises autour de quatre competences relatives a l'evaluation des apprentissages. Chaque sequence permet de partir du concret, de decouvrir des informations theoriques et/ou des pistes de travail, puis d'utiliser celles-ci a travers des exercices et de developper enfin une reflexion sur ses propres pratiques. Preface Introduction Differents parcours d'apprentissage Table des competences et des sequences Partie 1 L'apprentissage des competences Sequence 1 Les apprentissages ponctuels des ressources Sequence 2 L'apprentissage de la resolution de situations complexes Partie 2 L'evaluation par situations complexes Sequence 3 L'evaluation Sequence 4 La situation d'evaluation Sequence 5 Les criteres d'evaluation Sequence 6 La consigne et la regle des 2/3 Sequence 7 Les indicateurs d'evaluation Sequence 8 Le bareme de notation et la grille de correction Sequence 9 La validation d'epreuves par experimentation Partie 3 L'analyse des productions des eleves Sequence 10 La correction des copies d'eleves et la maitrise d'un critere Sequence 11 L'identifi cation des criteres non maitrises Sequence 12 La decision de reussite des eleves et la note Partie 4 L'analyse des difficultes de la remediation Sequence 13 L'identifi cation des diffi cultes des eleves Sequence 14 La remediation et la differenciation Sequence 15 Les activites de remediation et de differenciation Evaluation finale Sequence 16 Le brevet d'expert en evaluation de competences Conclusion L'evaluation, carotte, bâton, ou saine alimentation ? Bibliographie Index
POPULATION GAMES

Lawrence E. Blume SFI WORKING PAPER: 1996-04-022 SFI Working Papers contain accounts of scientific work of the author(s) and do not necessarily represent the views of the Santa Fe Institute. We accept papers intended for publication in peer-reviewed journals or proceedings volumes, but not papers that have already appeared in print. Except for papers by our external faculty, papers must be based on work done at SFI, inspired by an invited visit to or collaboration at SFI, or funded by an SFI grant. ©NOTICE: This working paper is included by permission of the contributing author(s) as a means to ensure timely distribution of the scholarly and technical work on a non-commercial basis. Copyright and all rights therein are maintained by the author(s). It is understood that all persons copying this information will adhere to the terms and constraints invoked by each author's copyright. These works may be reposted only with the explicit permission of the copyright holder. www.santafe. edu