Miracle-dz/UniFAR-FTUs huggingface dataset:
Bulk diffusion in a kinetically constrained lattice gas

In the hydrodynamic regime, the evolution of a stochastic lattice gas with symmetric hopping rules is described by a diffusion equation with density-dependent diffusion coefficient encapsulating all microscopic details of the dynamics. This diffusion coefficient is, in principle, determined by a Green–Kubo formula. In practice, even when the equilibrium properties of a lattice gas are analytically known, the diffusion coefficient cannot be computed except when a lattice gas additionally satisfies the gradient condition. We develop a procedure to systematically obtain analytical approximations for the diffusion coefficient for non-gradient lattice gases with known equilibrium. The method relies on a variational formula found by Varadhan and Spohn which is a version of the Green–Kubo formula particularly suitable for diffusive lattice gases. Restricting the variational formula to finite-dimensional sub-spaces allows one to perform the minimization and gives upper bounds for the diffusion coefficient. We apply this approach to a kinetically constrained non-gradient lattice gas in two dimensions, viz. to the Kob–Andersen model on the square lattice.
Working for citizenship: the dangers of occupational deprivation.

OBJECTIVE To examine published case examples of occupational deprivation in relation to Wilcock's 1989 theoretical proposal that it is caused by economic and political systems, institutional policies, or advances in technology that displace workers. CASE EXAMPLES Eleven accounts of occupational deprivation centering on access to or maintenance of a work role. METHOD A thematic review of articles reporting access to or maintenance of a worker role as a major concern were located in an electronic search of multiple databases using the keyword `occupational deprivation'. RESULTS While no examples pertaining to technological change were located, legislation enacted to protect national security or redress the ongoing affects of colonisation, a philosophy of punishing prisoners, and healthcare and employment structures were identified as causes of occupational deprivation. CONCLUSIONS Economic and political systems and institutional policies are confirmed to cause occupational deprivation of worker roles in prison and indigenous populations, migrant workers and older female immigrants, young women displaced by war, refugees and asylum seekers, and people with disabilities. The ongoing economic burden of wasting human potential and the loss of cultural practices that support productive occupations are two negative outcomes.
Copy move forgery detection with similar but genuine objects

Copy-Move Forgery Detection (CMFD) is a well-studied image forensics problem. However, CMFD with Similar but Genuine Objects (SGO) has received relatively less attention. Recently, it has been found that current state-of-the-art CFMD techniques are mostly inadequate in satisfactorily solving this important problem variant. In this paper, we have addressed this issue by using Rotated Local Binary Pattern (RLBP) based rotation-invariant texture features, followed by Generalized Two Nearest Neighbourhood (g2NN) based feature matching, hierarchical clustering and geometric transformation estimation. Experimental results show that our technique outperforms the state-of-the-art CFMD techniques for forged images having similar but genuine objects, and matches the accuracy of state-of-the-art techniques for other copy-move forgery types. Our method is also robust with respect to filtering and compression based post-processing.
An Enhanced Method to Estimate Heart Rate from Seismocardiography via Ensemble Averaging of Body Movements at Six Degrees of Freedom

Continuous cardiac monitoring has been developed to evaluate cardiac activity outside of clinical environments due to the advancement of novel instruments. Seismocardiography (SCG) is one of the vital components that could develop such a monitoring system. Although SCG has been presented with a lower accuracy, this novel cardiac indicator has been steadily proposed over traditional methods such as electrocardiography (ECG). Thus, it is necessary to develop an enhanced method by combining the significant cardiac indicators. In this study, the six-axis signals of accelerometer and gyroscope were measured and integrated by the L2 normalization and multi-dimensional kineticardiography (MKCG) approaches, respectively. The waveforms of accelerometer and gyroscope were standardized and combined via ensemble averaging, and the heart rate was calculated from the dominant frequency. Thirty participants (15 females) were asked to stand or sit in relaxed and aroused conditions. Their SCG was measured during the task. As a result, proposed method showed higher accuracy than traditional SCG methods in all measurement conditions. The three main contributions are as follows: (1) the ensemble averaging enhanced heart rate estimation with the benefits of the six-axis signals; (2) the proposed method was compared with the previous SCG method that employs fewer-axis; and (3) the method was tested in various measurement conditions for a more practical application.
Cost Effective, Reliable, and Secure Workflow Deployment over Federated Clouds

The federation of clouds can provide benefits for cloud-based applications. Different clouds have different advantages - one might be more reliable whilst another might be more secure or less expensive. However, being able to select the best combination of clouds to meet the application requirements is not trivial. This paper presents a novel algorithm to deploy workflow applications on federated clouds. Firstly, we introduce an entropy-based method to quantify the most reliable workflow deployments. Secondly, we apply an extension of the Bell-LaPadula Multi-Level security model to meet application security requirements. Finally, we optimise deployment in terms of its entropy and also its monetary cost, taking into account the price of computing power, data storage and inter-cloud communication. To evaluate the new algorithm we compared it against two existing scheduling algorithms: Dynamic Constraint Algorithm (DCA) and Biobjective dynamic level scheduling (BDLS). We show that our algorithm can find deployments that are of equivalent reliability, but are less expensive and also meet security requirements. We have validated our solution using workflows implemented in the e-Science Central cloud-based data analysis system.
Early Prediction of Tumor Response to Treatment: Preclinical Validation of 99mTc-Duramycin

Noninvasive imaging of cell death can provide an early indication of the efficacy of tumor treatment, aiding clinicians in distinguishing responding patients from nonresponding patients early on. 99mTc-duramycin is a SPECT tracer for cell death imaging. In this study, our aim was to validate the use of 99mTc-duramycin for imaging the early response of tumors to treatment. Methods: An in vitro binding assay was performed on COLO205 cells treated with 5-fluorouracil (3.1, 31, or 310 μM) and oxaliplatin (0.7 or 7 μM) or radiation (2 or 4.5 Gy). 99mTc-duramycin cell binding and the levels of cell death were evaluated after treatment. In vivo imaging was performed on 4 groups of CD1-deficient mice bearing COLO205 human colorectal cancer tumors. Each group included 6 tumors. The first group was given irinotecan (100 mg/kg), the second oxaliplatin (5 mg/kg), the third irinotecan (80 mg/kg) plus oxaliplatin (5 mg/kg), and the fourth vehicle (0.9% NaCl and 5% glucose). For radiotherapy studies, COLO205 tumors received 4.5 Gy, 2 fractions of 4.5 Gy in a 24-h interval, pretreatment with an 80 mg/kg dose of irinotecan combined with 2 fractions of 4.5 Gy in a 24-h interval, or no treatment (n = 5–6/group). Therapy response was evaluated by 99mTc-duramycin SPECT 24 h after the last dose of therapy. Blocking was used to confirm tracer specificity. Radiotracer uptake in the tumors was validated ex vivo using γ-counting, cleaved caspase-3, and terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick-end labeling (TUNEL) histology. Results: Chemotherapy and radiotherapy increased 99mTc-duramycin binding to COLO205 cells in a concentration/dose- and time-dependent manner, which correlated well with cell death levels (P < 0.05) as analyzed by annexin V and caspase 3/7 activity. In vivo, 99mTc-duramycin uptake in COLO205 xenografts was increased 2.3- and 2.8-fold (P < 0.001) in mice treated with irinotecan and combination therapy, respectively. Blocking with unlabeled duramycin demonstrated specific binding of the radiotracer. After tumor irradiation with 4.5 Gy, 99mTc-duramycin uptake in tumors increased significantly (1.24 ± 0.07 vs. 0.57 ± 0.08 percentage injected dose per gram in the unirradiated tumors; P < 0.001). γ-counting of radioactivity in the tumors positively correlated with cleaved caspase-3 (r = 0.85, P < 0.001) and TUNEL (r = 0.81, P < 0.001) staining. Conclusion: We demonstrated that 99mTc-duramycin can be used to image induction of cell death early after chemotherapy and radiotherapy. It holds potential to be translated into clinical use for early assessment of treatment response.
Loneliness, Insomnia and Suicidal Behavior among School-Going Adolescents in Western Pacific Island Countries: Role of Violence and Injury

This study aimed to examine whether being bullied, fighting, and injury, regarded in terms of frequency and nature, were significantly associated with psychological distress and suicidal behavior, independent of substance abuse and parental support in adolescents. Secondary analysis of data from the Global School-based Student Health Survey from Kiribati, the Solomon Islands, and Vanuatu was conducted. Binomial logistic regression analysis was used to examine the association of being bullied, fighting and injury with psychological health outcomes (loneliness, insomnia, suicidal ideation and suicide attempt) at a 5% level of significance. A total of 4122 students were included; 45.5% were male, and 52.0% were 14 years of age or younger. Of the total, 9.3% felt lonely and 9.5% had insomnia most of the time over the last 12 months; 27.6% had suicidal ideation, and 30.9% reported at least one suicide attempt in the last 12 months. Multivariable logistic regression analysis showed that being bullied, fighting and injury were significantly associated with psychological health outcomes; adjusted odds ratios (AORs) of loneliness, insomnia, suicidal ideation and suicide attempt increased with increased exposure to bullying, fighting, and injury compared to non-exposed group. Among the types of bullying victimization, the highest AORs of insomnia and suicide attempt were among students who were left out of activities, compared to the non-bullied. Among the causes of injury, adolescents injured due to a physical attack were the most likely to report the highest AORs of loneliness, insomnia and suicidal ideation compared to those not injured. Preventing violence and injury among adolescents might contribute to better mental health and reduction of suicidal behavior.
Comprehensive Tool Support for Enterprise Modeling and Evaluation

Enterprise modelling and evaluating subsequently created models is manifold. Enterprise modelling means capturing an organization's business processes, its organizational structure, its corporate strategy, or its supporting information systems in graphical conceptual models. Evaluating these models means assuring their structural and semantic quality as well as their user group adequacy. Enterprise modelling and model evaluation requires comprehensive tool support. Recently, a number of modelling tools have been proposed each addressing particular aspects of enterprise modelling or model evaluation. For example, meta-modelling tools allow for defining new and altering existing modelling languages. Meta-modelling tools are thus well suited for enterprise modelling as this requires a large number of different modelling languages that may need to be adapted to the particular enterprise. In contrast, some modelling tools provide mechanisms to structurally or semantically evaluate models of a predefined language. However, comprehensive tool support for enterprise modelling and model evaluation is missing up to now. With this paper, the authors aim at closing this research gap by proposing a tool combining meta-modelling capabilities with features to structurally and semantically evaluate models as well as to manage model perspectives. The tool thus covers the entire model lifecycle from defining a problem-suitable modelling language, creating models, configuring them for different user groups, and evaluating them in terms of structure and semantics.
Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2.

BACKGROUND Most persons who are infected with human immunodeficiency virus type 1 (HIV-1) are also infected with herpes simplex virus type 2 (HSV-2), which is frequently reactivated and is associated with increased plasma and genital levels of HIV-1. Therapy to suppress HSV-2 reduces the frequency of reactivation of HSV-2 as well as HIV-1 levels, suggesting that suppression of HSV-2 may reduce the risk of transmission of HIV-1. METHODS We conducted a randomized, placebo-controlled trial of suppressive therapy for HSV-2 (acyclovir at a dose of 400 mg orally twice daily) in couples in which only one of the partners was seropositive for HIV-1 (CD4 count, > or = 250 cells per cubic millimeter) and that partner was also infected with HSV-2 and was not taking antiretroviral therapy at the time of enrollment. The primary end point was transmission of HIV-1 to the partner who was not initially infected with HIV-1; linkage of transmissions was assessed by means of genetic sequencing of viruses. RESULTS A total of 3408 couples were enrolled at 14 sites in Africa. Of the partners who were infected with HIV-1, 68% were women, and the baseline median CD4 count was 462 cells per cubic millimeter. Of 132 HIV-1 seroconversions that occurred after randomization (an incidence of 2.7 per 100 person-years), 84 were linked within couples by viral sequencing: 41 in the acyclovir group and 43 in the placebo group (hazard ratio with acyclovir, 0.92, 95% confidence interval [CI], 0.60 to 1.41; P=0.69). Suppression with acyclovir reduced the mean plasma concentration of HIV-1 by 0.25 log(10) copies per milliliter (95% CI, 0.22 to 0.29; P<0.001) and the occurrence of HSV-2-positive genital ulcers by 73% (risk ratio, 0.27; 95% CI, 0.20 to 0.36; P<0.001). A total of 92% of the partners infected with HIV-1 and 84% of the partners not infected with HIV-1 remained in the study for 24 months. The level of adherence to the dispensed study drug was 96%. No serious adverse events related to acyclovir were observed. CONCLUSIONS Daily acyclovir therapy did not reduce the risk of transmission of HIV-1, despite a reduction in plasma HIV-1 RNA of 0.25 log(10) copies per milliliter and a 73% reduction in the occurrence of genital ulcers due to HSV-2. (ClinicalTrials.gov number, NCT00194519.)
Detecting non-functional circuit activity in SoC designs

In this paper, we present a methodology for the automatic detection of non-functional circuit activity in SoC designs. Our methodology formally analyses an RTL design, generates an internal graph representation and traverses the graph using given simulation traces. We evaluate an open source processor with a given set of benchmark applications using our approach. With a commercial RTL simulator, we observe an average register toggle activity of 6.7%–11.5%, but our experiments show that 86.1–92.7% of these toggles are non-functional, i.e. not necessary for producing the exact same circuit output. We further evaluate the efficiency of the clock gating architecture of a commercial ASIP. For the Dhrystone benchmark we show that, even though only 34.7% of the registers are clocked on average, still 64.3% of the non-clock-gated registers in this ASIP are not needed on average to produce exactly the same circuit output.
Mechanics of Orthogonal Machining: Allowing for the Effects of Strain Rate and Temperature on Tool-Chip Friction

An analysis of orthogonal machining is given in which the mean angle of friction usually used to describe the frictional condition at the tool-chip interface is replaced by the average shear stress along this interface. If this shear stress is expressed as a function of strain rate and temperature, using a velocity-modified temperature, there is good agreement between theory and experiment.
Identification and characterization of novel enhanced cell penetrating peptides for anti-cancer cargo delivery

Cell penetrating peptides (CPP) are able cross the membrane and to transport cargos, presenting a great potential in drug delivery and diagnosis. In this paper, we have identified novel natural or synthetic CPPs. We have validated their rapid and efficient time and dose-dependent penetration, the absence of toxicity, the intracellular localization and the stability to proteases degradation, one of the main bottlenecks of peptides. Moreover, we have associate a cargo (an interfering peptide blocking the association of the serine/threonine phosphatase PP2A to its inhibitor, the oncogene SET) to the new generated shuttles and showed that they new bi-functional peptides keep the original properties of the shuttle and, in addition, are able to induce apoptosis due to the properties of the cargo. The CPPs identified in this study have promising perspectives for future anti-cancer drug delivery.
A risk score including microdeletions improves relapse prediction for standard and medium risk precursor B‐cell acute lymphoblastic leukaemia in children

To prevent relapse, high risk paediatric acute lymphoblastic leukaemia (ALL) is treated very intensively. However, most patients who eventually relapse have standard or medium risk ALL with low minimal residual disease (MRD) levels. We analysed recurrent microdeletions and other clinical prognostic factors in a cohort of 475 uniformly treated non‐high risk precursor B‐cell ALL patients with the aim of better predicting relapse and refining risk stratification. Lower relapse‐free survival at 7 years (RFS) was associated with IKZF1 intragenic deletions (P < 0·0001); P2RY8‐CRLF2 gene fusion (P < 0·0004); Day 33 MRD>5 × 10−5 (P < 0·0001) and High National Cancer Institute (NCI) risk (P < 0·0001). We created a predictive model based on a risk score (RS) for deletions, MRD and NCI risk, extending from an RS of 0 (RS0) for patients with no unfavourable factors to RS2 + for patients with 2 or 3 high risk factors. RS0, RS1, and RS2 + groups had RFS of 93%, 78% and 49%, respectively, and overall survival (OS) of 99%, 91% and 71%. The RS provided greater discrimination than MRD‐based risk stratification into standard (89% RFS, 96% OS) and medium risk groups (79% RFS, 91% OS). We conclude that this RS may enable better early therapeutic stratification and thus improve cure rates for childhood ALL.
New Biomarkers in the Retina and RPE Under Oxidative Stress

Age-related macular degeneration (AMD) involves progressive cell death of post-mitotic retinal pigment epithelial (RPE) cells, which adversely affects rod and cone survival. RPE cells are exposed to chronic oxidative stress, including constant exposure to intense light and increased reactive oxygen species (ROS) from mitochondria due to high levels of oxygen consumption. However, understanding how oxidative stress causes phosphoproteomic alterations that initiate death signals in the RPE is elusive. Lack of such knowledge is an important problem, because, without it, acquiring the ability to modulate cellular protection is highly unlikely.
STC2 promotes head and neck squamous cell carcinoma metastasis through modulating the PI3K/AKT/Snail signaling

The mammalian peptide hormone stanniocalcin 2 (STC2) plays an oncogenic role in many human cancers. However, the exact function of STC2 in human head and neck squamous cell carcinoma (HNSCC) is unclear. We aimed to examine the function and clinical significance of STC2 in HNSCC. Using in vitro and in vivo assays, we show that overexpression of STC2 suppressed cell apoptosis, promoted cell proliferation, migration, invasion, and cell cycle arrest at the G1/S transition. By contrast, silencing of STC2 inhibited these activities. We further show that STC2 upregulated the phosphorylation of AKT and enhanced HNSCC metastasis via Snail-mediated increase of vimentin and decrease of E-cadherin. These responses were blocked by silencing of STC2/Snail expression or inhibition of pAKT activity. Furthermore, clinical data indicate that high STC2 expression was associated with high levels of pAKT and Snail in tumor samples from HNSCC patients with regional lymph node metastasis (P < 0.01). Thus, we conclude that STC2 controls HNSCC metastasis via the PI3K/AKT/Snail signaling axis and that targeted therapy against STC2 may be a novel strategy to effectively treat patients with metastatic HNSCC.
NLRC and NLRX gene family mRNA expression and prognostic value in hepatocellular carcinoma

Nucleotide‐binding oligomerization domain (NOD)‐like receptor (NLR)C and NLRX family proteins play a key role in the innate immune response. The relationship between these proteins and hepatocellular carcinoma (HCC) remains unclear. This study investigated the prognostic significance of NLRC and NLRX family protein levels in HCC patients. Data from 360 HCC patients in The Cancer Genome Atlas database and 231 patients in the Gene Expression Omnibus database were analyzed. Kaplan–Meier analysis and a Cox regression model were used to determine median survival time (MST) and overall and recurrence‐free survival by calculating the hazard ratio (HR) and 95% confidence interval (CI). High NOD2 and low NLRX1 expression in tumor tissue was associated with short MST (P = 0.012 and 0.014, respectively). A joint‐effects analysis of NOD2 and NLRX1 combined revealed that groups III and IV had reduced risk of death from HCC as compared to group I (adjusted P = 0.001, adjusted HR = 0.31, 95% CI = 0.16–0.61 and adjusted P = 0.043, adjusted HR = 0.63, 95%CI = 0.41–0.99, respectively). NOD2 and NLRX1 expression levels are potential prognostic markers in HCC following hepatectomy.
Production of High Loaded Paper by Dual Flow Additions of Fillers (I) -Effects of Filler Addition at Thick Stock on Paper Properties and Papermaking Process -

Fillers have been used for papermaking in order to enhance the optical properties, to improve sheet formation, printability and dimensional stability and to reduce the furnish cost. However, filler particles in paper interfere with fiber-fiber bonding, resulting in decreased paper strength. In order to increase filler content in paper without sacrificing too much paper strength, dual addition technology of fillers was investigated. As a first step, the effects of thick stock addition of fillers on paper properties and papermaking process were elucidated. It was shown that thick stock addition of fillers could increase paper strength at a given filler content. No significant adverse effects on formation, drainage and filler retention were observed. However, bulk of paper was reduced with thick stock addition of fillers, which shall be resolved with regulating other factors such as the mixing ratio of pulps and type of fillers.