Miracle-dz/UniFAR-FTUs huggingface dataset:
Interconnexion et visualisation de ressources géoréférencées du Web de données à l'aide d'un référentiel topographique de support. (Interlinking and visualizing georeferenced resources of the Web of data with geographic reference data)

Plusieurs ressources publiees sur le Web de donnees sont dotees de references spatiales qui decrivent leur localisation geographique. Ces references spatiales sont un moyen favori pour interconnecter et visualiser les ressources sur le Web de donnees. Cependant, les heterogeneites des niveaux de detail et de modelisations geometriques entre les sources de donnees constituent un defi majeur pour l’utilisation de la comparaison des references spatiales comme critere pour l’interconnexion des ressources. Ce defi est amplifie par la nature ouverte et collaborative des sources de donnees du Web qui engendre des heterogeneites geometriques internes aux sources de donnees. En outre, les applications de visualisation cartographique des ressources georeferencees du Web de donnees ne fournissent pas une visualisation lisible a toutes les echelles.Dans cette these, nous proposons un vocabulaire pour formaliser les connaissances sur les caracteristiques de chaque geometrie dans un jeu de donnees. Nous proposons egalement une approche semi-automatique basee sur un referentiel topographique pour acquerir ces connaissances. Nous proposons de mettre en oeuvre ces connaissances dans une approche d’adaptation dynamique du parametrage de la comparaison des geometries dans un processus d’interconnexion. Nous proposons une approche complementaire s’appuyant sur un referentiel topographique pour la detection des liens de cardinalite n:m. Nous proposons finalement des applications qui s’appuient sur des donnees topographiques de reference et leurs liens avec les ressources georeferencees du Web pour offrir une visualisation cartographique multiechelle lisible et conviviale
Partage de documents sécurisé dans le Cloud Personnel. (Secure document sharing through Personnal Cloud)

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Partage de documents sécurisé dans le Cloud Personnel Paul Tran Van
Beyond brain size: Uncovering the neural correlates of behavioral and cognitive specialization

We thank our funders: the Isaac Newton Trust and Leverhulme Trust for a Leverhulme Early Career Fellowship to CJL, which funded the workshop on which this article is based; NERC for an Independent Research Fellowship to SHM; the European Research Council (Grant No. 3399933; SAJ); the Royal Society for a Dorothy Hodgkin Research Fellowship to NJB; the Royal Society of New Zealand Marsden Fund (UOC1301; FRC); the National Science Foundation (NSF BCS 1440755; RM); the John Templeton Foundation (AB); and the Templeton World Charity Foundation (AC; Note: The opinions expressed in this publication are those of the author(s) and do not necessarily reflect the views of Templeton World Charity Foundation).
The Emerging Roles for Telomerase in the Central Nervous System

Telomerase, a specialized ribonucleoprotein enzyme complex, maintains telomere length at the 3′ end of chromosomes, and functions importantly in stem cells, cancer and aging. Telomerase exists in neural stem cells (NSCs) and neural progenitor cells (NPCs), at a high level in the developing and adult brains of humans and rodents. Increasing studies have demonstrated that telomerase in NSCs/NPCs plays important roles in cell proliferation, neuronal differentiation, neuronal survival and neuritogenesis. In addition, recent works have shown that telomerase reverse transcriptase (TERT) can protect newborn neurons from apoptosis and excitotoxicity. However, to date, the link between telomerase and diseases in the central nervous system (CNS) is not well reviewed. Here, we analyze the evidence and summarize the important roles of telomerase in the CNS. Understanding the roles of telomerase in the nervous system is not only important to gain further insight into the process of the neural cell life cycle but would also provide novel therapeutic applications in CNS diseases such as neurodegenerative condition, mood disorders, aging and other ailments.
The Role of Management Advisory Services in Accounting Firms: A Preliminary Study

In this study I examine the role of management advisory services in accounting firms. Specifically I evaluate whether accounting firm productivity, in terms of revenue generation based on human resources utilized, increases with greater provision of management advisory services. Empirical results indicate that the productivity of Korean accounting firms increased with the proportion of management advisory services in the revenue mix. This means that if public accounting firms operated solely in the traditional service areas of auditing and taxation services, they would earn lower revenues based on the human inputs employed.
Microdevice‐based solid‐phase polymerase chain reaction for rapid detection of pathogenic microorganisms

We demonstrate the integration of DNA amplification and detection functionalities developed on a lab‐on‐a‐chip microdevice utilizing solid‐phase polymerase chain reaction (SP‐PCR) for point‐of‐need (PON) DNA analyses. First, the polycarbonate microdevice was fabricated by thermal bonding to contain microchambers as reservoirs for performing SP‐PCR. Next, the microchambers were subsequently modified with polyethyleneimine and glutaraldehyde for immobilizing amine‐modified forward primers. During SP‐PCR, the immobilized forward primers and freely diffusing fluorescence‐labeled reverse primers cooperated to generate target amplicons, which remained covalently attached to the microchambers for the fluorescence detection. The SP‐PCR microdevice was used for the direct identifications of two widely detected foodborne pathogens, namely Salmonella spp. and Staphylococcus aureus, and an alga causing harmful algal blooms annually in South Korea, Cochlodinium polykrikoides. The SP‐PCR microdevice would be versatilely applied in PON testing as a universal platform for the fast identification of foodborne pathogens and environmentally threatening biogenic targets.
Effect of Cannabidiol on Drop Seizures in the Lennox–Gastaut Syndrome

Background Cannabidiol has been used for treatment‐resistant seizures in patients with severe early‐onset epilepsy. We investigated the efficacy and safety of cannabidiol added to a regimen of conventional antiepileptic medication to treat drop seizures in patients with the Lennox–Gastaut syndrome, a severe developmental epileptic encephalopathy. Methods In this double‐blind, placebo‐controlled trial conducted at 30 clinical centers, we randomly assigned patients with the Lennox–Gastaut syndrome (age range, 2 to 55 years) who had had two or more drop seizures per week during a 28‐day baseline period to receive cannabidiol oral solution at a dose of either 20 mg per kilogram of body weight (20‐mg cannabidiol group) or 10 mg per kilogram (10‐mg cannabidiol group) or matching placebo, administered in two equally divided doses daily for 14 weeks. The primary outcome was the percentage change from baseline in the frequency of drop seizures (average per 28 days) during the treatment period. Results A total of 225 patients were enrolled; 76 patients were assigned to the 20‐mg cannabidiol group, 73 to the 10‐mg cannabidiol group, and 76 to the placebo group. During the 28‐day baseline period, the median number of drop seizures was 85 in all trial groups combined. The median percent reduction from baseline in drop‐seizure frequency during the treatment period was 41.9% in the 20‐mg cannabidiol group, 37.2% in the 10‐mg cannabidiol group, and 17.2% in the placebo group (P=0.005 for the 20‐mg cannabidiol group vs. placebo group, and P=0.002 for the 10‐mg cannabidiol group vs. placebo group). The most common adverse events among the patients in the cannabidiol groups were somnolence, decreased appetite, and diarrhea; these events occurred more frequently in the higher‐dose group. Six patients in the 20‐mg cannabidiol group and 1 patient in the 10‐mg cannabidiol group discontinued the trial medication because of adverse events and were withdrawn from the trial. Fourteen patients who received cannabidiol (9%) had elevated liver aminotransferase concentrations. Conclusions Among children and adults with the Lennox–Gastaut syndrome, the addition of cannabidiol at a dose of 10 mg or 20 mg per kilogram per day to a conventional antiepileptic regimen resulted in greater reductions in the frequency of drop seizures than placebo. Adverse events with cannabidiol included elevated liver aminotransferase concentrations. (Funded by GW Pharmaceuticals; GWPCARE3 ClinicalTrials.gov number, NCT02224560.)
Performance of a Nonparametric Multivariate Nearest Neighbor Model in the Prediction of Stock Index Returns

This paper investigates the predictability of stock index returns using a nonparametric multivariate nearest neighbor model. A cross validation method that minimizes the mean square error is used to determine the embedding dimensions and the number of neighbors optimally. The performance of the proposed model is demonstrated using the KOSPI composite index and 16 industry indexes.
Identifying Periods of US Housing Market Explosivity

In this paper we set out to date-stamp periods of US housing price explosivity for the period 1830 – 2013. We make use of several robust techniques that allow us to identify such periods by determining when prices start to exhibit explosivity with respect to its past behaviour and when it recedes to long term stable prices. The first technique used is the Generalized sup ADF (GSADF) test procedure developed by Phillips, Shi, and Yu (2013), which allows the recursive identification of multiple periods of price explosivity. The second approach makes use of Robinson (1994)’s test statistic, comparing the null of a unit root process against the alternative of specified orders of fractional integration. Our analysis date-stamps several periods of US house price explosivity, allowing us to contextualize its historic relevance.
Determination of protein charge variants with (imaged) capillary isoelectric focusing and capillary zone electrophoresis

Biopharmaceuticals are increasingly present in pharmaceutical therapy. These highly complex molecules are still challenging for development and quality control. Charge heterogeneity is next to size heterogeneity, glycan analysis, or peptide mapping one main aspect of their thorough characterization. This review focuses on the charge‐based analysis of biopharmaceuticals through CE. An overview is given about the three separation techniques cIEF, imaged cIEF and CZE for the analyses of charge variants, emphasizing assays and their precision. Especially the developments in the experimental conditions have been given a high priority: sample preparation, capillary properties, anolytes and catholytes, carrier ampholytes, sacrificing agents, solubility enhancement, isoelectric point marker, mobilization techniques, and detection modes have been discussed. CIEF shows a particularly high heterogeneity in its methods. Therefore, a design space is suggested that states the most important adjustable parameters and their range. This enables an adequate design of experiments for individual sample separations, in order to accelerate and simplify method developments.
An Evaluation of Coding Violation Focusing on Change History and Authorship of Source File

This paper focuses on an evaluation of coding violation warned by a static code analysis tool while considering the change history of violation and the authorship of source file. Through an empirical study with data collected from seven open source software projects, the following findings are reported: (1) the variety and the evaluation of a coding violation tend to vary accroding to the authoring type of the source file; (2) while important violations tend to vary from project to project, about 30% of violations are commonly disregarded by many programmers.
A UIMA Database Interface for Managing NLP-related Text Annotations

NLP and automatic text analysis necessarily involve the annotation of natural language texts. The Apache Unstructured Information Management applications (UIMA) framework is used in several projects, tools and resources, and has become a de facto standard in this area. Despite the multiple use of UIMA as a document-based schema, it does not provide native database support. In order to facilitate distributed storage and enable UIMA-based projects to perform targeted queries, we have developed the UIMA Database Interface (UIMA DI). UIMA DI sets up an environment for a generic use of UIMA documents in database systems. In addition, the integration of UIMA DI into rights and resource management tools enables user and group-speciﬁc access to UIMA documents and provides data protection. Finally, UIMA documents can be made accessible for third party programs. UIMA DI, which we evaluate in relation to ﬁle system-based storage, is available under the GPLv3 license via GitHub.
Isolation and characterization of Listeria species from raw and processed meats.

A total of 109 meat and meat product samples (50 beef, 52 pork sausages and 7 pork) were examined for the presence of Listeria species. Isolates were confirmed by biochemical characterization and haemolysis on blood agar. A total of 25 (22.94%) isolates were recovered. Of these, 7 (6.42%) were L. monocytogenes, while one (0.9%) was L. ivanovii. Other isolates were L. seeligeri (10), L. innocua (4), L. welshimeri (2) and L. grayi (1). All the isolates were further subjected to a PCR assay for detection of the hlyA gene, the hlyA gene was detected in 7 isolates. Multiplex-PCR serotyping assay revealed three of the strains belonging to serovar group 4b, 4d, 4e, and four to serovar group 1/2a, 3a. The prevalence of L. monocytogenes in raw meat, particularly serogroup 4b, 4d, 4e in present study indicates a potential threat to public health.
Biphasic myosin II light chain activation during clot retraction

Summary Clot retraction is an essential step during primary haemostasis, thereby promoting thrombus stability and wound healing. Integrin αIIbβ3 plays a critical role in clot retraction, by inducing acto-myosin interactions that allow platelet cytoskeleton reorganisation. However, the signalling pathways that lead to clot retraction are still misunderstood. In this study, we report the first data on the kinetics of myosin II light chain (MLC) phosphorylation during clot retraction. We found an early phosphorylation peak followed by a second peak. By using specific inhibitors of kinases and small G proteins, we showed that MLC kinase (MLCK), RhoA/ROCK, and Rac-1 were involved in clot retraction and in the early MLC phosphorylation peak. Only Rac-1 and actin polymerisation, controlled by outside-in signalling, were crucial to the second MLC phosphorylation peak.
Chapter 7 Reference growth charts for Saudi Arabian children and adolescents

The purpose of this study is to provide Saudi Arabian population reference growth standards for height, weight, body mass index (BMI), head circumference and weight for length/stature. The estimated distribution centiles are obtained by splitting the population into two separate age groups: infants, birth to 36 months and children and adolescents, age 2 to 19 years. The reference values were derived from cross-sectional data applying the LMS method of Cole and Green (Stat. in Medicine 1992; 11:1305-1319) using the lmsqreg package in R (public domain language for data analysis, 2009). The report provides an overview of how the method has been applied, more specifically how the relevant issues concerning the construction of the growth charts have been addressed and is illustrated by just using the girls weight data (birth to three years old). These issues include identifying the outliers, diagnosing the appropriate amounts of smoothing and averaging the reference standards for the overlapping 2 to 3 year age range. The use of ANCOVA has been introduced and illustrated as a tool for making growth standard comparisons between different geographical regions and between genders.
Detecting promoter methylation pattern of apoptotic genes Apaf1 and Caspase8 in gastric carcinoma patients undergoing chemotherapy.

Background DNA methylation patterns in cells dysregulation CpG island methylation of genes involved in cancer leads to increased levels of the cancer. Restoration of the apoptotic route in tumor cells of stomach in order for placing Casp8 and Apaf1 genes is a proper approach for new treatments of gastric cancer. The objective of the present study was to investigate the relationship between the pattern of methylation promoter in apoptotic genes of Casp8 and Apaf1 and gastric carcinoma in patients receiving chemotherapy. Methods Genomic DNA was extracted from 30 samples of FFPE tumor, normal tissues and blood samples. Hyper-methylation analysis of Casp8 and Apaf1 genes was conducted using MSP method; the results were analyzed through electrophoresis on agarose gel and software spss20. Results In this study, methylation rate of Apaf1 gene with (P>0.05) was not significant but methylation rate of Casp8 gene with (P<0.05) was significant. In addition, there was a significant relationship between Apaf1 gene methylation in blood with stage (P<0.05), Apaf1 gene methylation in tissue with stage (P<0.05) and grade (P<0.01) and between Casp8 gene methylation in blood with age (P<0.001) of patients but no significant relationship was seen for other factors. Conclusions Our results suggest that epigenetic mechanisms play an important role in the pathogenesis of gastric cancer and can be utilized as prognostic biomarkers for it. Also no significant difference between Casp8 and Apaf1 promoter hypermethylation in blood and tissue samples indicated that methylation status of blood sample can be early and non-invasive diagnostic marker in gastric cancer.
RePage: A Novel Over-Air Reprogramming Approach Based on Paging Mechanism Applied in Fog Computing

In fog computing, fog nodes running different tasks near the sources of data are required. Limited to on-board resource, fog node finds it hard to execute multiple tasks and needs over-air reprogramming to rearrange them. With respect to reprogramming, energy efficiency is one of the key issues for over-air reprogramming. Most of traditional reprogramming approaches focus on the energy efficiency during data transmission within network. However, program rebuilding on fog node is, as another significant energy cost, caused by writing/reading local high-power memory. We present a novel incremental reprogramming approach, RePage, in three stages. Firstly, we design a function paging mechanism that makes similar functions to one function page and caches them in low-power volatile memory to save energy. Secondly, we design new cache replacement algorithm for function page considering both modification times and range on the page. At last, further reducing writing/reading operations, we also redesign function invocation manner by centralized managing function addresses. Experiment results show that RePage reduces the sum of reading/writing operations on volatile memory by 89.1% and 92.5% compared to EasiCache and Tiny Module-link, and its hit rate is improved by 10.4% to Least Recently Used (LRU) algorithm.
Quantitative Determination of Thiol Status of Proteins and Cells by Nitroxyl Biradical .RS-SR.

In cells, the ratio/equilibrium between oxidized and reduced forms of glutathione and between cysteine and cystine (main cells antioxidants) affect thiol balance and redox status of cells and proteins (4). In general, spectroscopic and chromatographic methods are used for quantitative determination of low-molecular thiols and sulfhydryl groups in proteins. Optical methods are employed to detect absorption or fluorescence, which appears on results of interaction between reagents and free SH groups. However, samples must be optically transparent, so preliminary homogenation and centrifugation of biological samples and other procedures are necessary (4). Chromatographic methods, especially HPLC (4), cannot be used for express analysis of thiol status of biological samples.
Adjusted linguistic validation and psychometric properties of the Colombian version of KIDSCREEN-52

In health and clinical studies, health-related quality of life is often assessed using the well-established KIDSCREEN-52 questionnaires as well as the Vécu et Santé Perçue de l’Adolescent (VSP-A). The purpose of this study was twofold: to perform an adjusted linguistic validation of the Colombian version of the KIDSCREEN-52 and to assess its psychometric properties in children and adolescents. A total of 146 children and adolescents completed the KIDSCREEN-52, adolescents (n = 48) additionally completed the VSP-A. Psychometric analyses focused on the internal consistency as well as the convergent and discriminant validity of the KIDSCREEN-52 Colombian version. Syntactic and semantic modifications were made to 19 items in the adapted version of the KIDSCREEN-52. Cronbach’s α ranged from . 74 to . 89 for eight dimensions, while α < . 70 was obtained for self-perception and social acceptance. We found evidence of good convergent validity with the VSP-A dimensions. Regarding known-groups validity, children aged between 8 and 10=years, male, with a high socioeconomic level and no chronic health condition obtained higher scores compared to the other categories. The developed Colombian version of the KIDSCREEN-52 showed acceptable reliability and validity. This study provides a cultural adaptation of the Spanish version of the KIDSCREEN-52 for Colombian children and adolescents.
Therapeutic Antibodies for Myeloid Neoplasms—Current Developments and Future Directions

Therapeutic monoclonal antibodies (mAbs) such as antibody–drug conjugates, ligand–receptor antagonists, immune checkpoint inhibitors and bispecific T cell engagers have shown impressive efficacy in the treatment of multiple human cancers. Numerous therapeutic mAbs that have been developed for myeloid neoplasms, including acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), are currently investigated in clinical trials. Because AML and MDS originate from malignantly transformed hematopoietic stem/progenitor cells—the so-called leukemic stem cells (LSCs) that are highly resistant to most standard drugs—these malignancies frequently relapse and have a high disease-specific mortality. Therefore, combining standard chemotherapy with antileukemic mAbs that specifically target malignant blasts and particularly LSCs or utilizing mAbs that reinforce antileukemic host immunity holds great promise for improving patient outcomes. This review provides an overview of therapeutic mAbs for AML and MDS. Antibody targets, the molecular mechanisms of action, the efficacy in preclinical leukemia models, and the results of clinical trials are discussed. New developments and future studies of therapeutic mAbs in myeloid neoplasms will advance our understanding of the immunobiology of these diseases and enhance current therapeutic strategies.