Miracle-dz/UniFAR-FTUs huggingface dataset:
Greater fatigability in knee-flexors vs. knee-extensors after a standardized fatiguing protocol

Abstract The present study aimed to investigate the effects of a standardized fatiguing protocol on central and peripheral fatigue in knee-flexors and knee-extensors. Thirteen healthy men (age: 23 ± 3 years; height: 1.78 ± 0.09 m; body-mass: 73.6 ± 9.2 kg) volunteered for the present study. Maximal voluntary contraction (MVC), Electromyography (EMG) activity, voluntary activation level (VAL) as an index of central fatigue and twitch potentiation as an index of peripheral fatigue were measured before and after the fatiguing protocol. The fatiguing protocol consisted of a 0.6 duty-cycle to exhaustion (6 s isometric contraction, 4 s recovery) at 70% MVC. After the fatiguing protocol, MVC decreased in both (Effect-size (ES) = 1.14) and knee-extensors (ES = 1.14), and EMG activity increased in both knee-flexors (ES = 2.33) and knee-extensors (ES = 1.54). Decreases in VAL occurred in knee-flexors (ES = 0.92) but not in knee-extensors (ES = 0.04). Decreases in potentiation occurred in both knee-flexors (ES = 0.84) and knee-extensors (ES = 0.58). The greater central occurrence of fatigue in knee-flexors than in knee-extensors may depend on the different muscle morphology and coupled with a greater tolerance to fatigue in knee-extensors. The present data add further insight to the complicated knee-flexors-to-knee-extensors strength relationship and the mechanisms behind the different occurrence of fatigue.
NGF and iNOS Changes in Tears from Video Display Terminal Workers

ABSTRACT Purpose: To investigate Nerve Growth Factor (NGF) and nitric oxide synthase (iNOS) levels in tears obtained from Video Display Terminal (VDT) workers and correlate their expression with ocular signs and symptoms. Methods: A total of 120 VDT workers (62M/58F; 31–63 years old) and 40 age/sex matched no-VDT volunteers (19M/21F; 30–60 years old) were enrolled in the study. Participants completed the OSDI questionnaire and were subjected to clinical assessment of ocular surface status, including ocular symptoms and tear film parameters. NGF and iNOS levels were quantified in tear samples and their expressions correlated with OSDI, ocular symptoms and tear film parameters. Results: 59.17% of the studied population was symptomatic based on OSDI scores. Women were more commonly affected. The most frequent symptom was asthenopia and except for dryness, no differences were found between genders regarding other symptoms. A statistically significant decrease in NGF levels was found between normal and moderate (p < 0.05) and between mild and moderate (p < 0.05) OSDI grading. iNOS expression was increased in moderate OSDI grading compared to normals (p < 0.05). A negative correlation was found between NGF and respectively OSDI results, dryness and blurry vision (p < 0.05). No correlations were found among NGF, iNOS and ocular surface parameters (Schirmer, BUT, ocular surface staining). Conclusion: Our data suggest that NGF and iNOS levels contribute to VDT ocular discomfort. Further studies are required to better understand the relationship between NGF and iNOS in VDT ocular surface.
Towards an Unequivocal Representation of Actions

This work introduces verb-only representations for actions and interactions; the problem of describing similar motions (e.g. 'open door', 'open cupboard'), and distinguish differing ones (e.g. 'open door' vs 'open bottle') using verb-only labels. Current approaches for action recognition neglect legitimate semantic ambiguities and class overlaps between verbs (Fig. 1), relying on the objects to disambiguate interactions. We deviate from single-verb labels and introduce a mapping between observations and multiple verb labels - in order to create an Unequivocal Representation of Actions. The new representation benefits from increased vocabulary and a soft assignment to an enriched space of verb labels. We learn these representations as multi-output regression, using a two-stream fusion CNN. The proposed approach outperforms conventional single-verb labels (also known as majority voting) on three egocentric datasets for both recognition and retrieval.
The Relationship between Actual Fundamental Motor Skill Proficiency, Perceived Motor Skill Confidence and Competence, and Physical Activity in 8–12-Year-Old Irish Female Youth

This study examines the relationship between actual fundamental motor skill (FMS) proficiency, perceived motor confidence and competence, and physical activity (PA) among female children (n= 160; mean age = 10.69 ± 1.40 years). The Test of Gross Motor Development-2nd Edition (TGMD-2) was used to assess seven FMSs (locomotor, object-control, and stability). Motor confidence and competence were assessed using a valid skill-specific scale, and a modified version of the Self-Perception Profile for Children. PA levels were assessed using self-report (PA Questionnaire for Older Children (PAQ-C)) and classified as low, moderate, and high active. One-way and two-way ANOVAs (post-hoc honest significant difference (HSD)) and correlation coefficients were used to analyse the data. Findings indicate that the majority of youth (71.8%) were not meeting the minimum 60 min of daily PA recommended for health, and that 98.1% did not achieve the FMS proficiency expected for their age. While there were high levels of perceived physical self-confidence (PSC) reported within FMS skill-specific tasks, there was no significant correlation observed between actual FMS proficiency and perceived PSC among the cohort. Results show that low, moderately, and highly active female participants differ significantly in terms of their overall FMS (p = 0.03) and locomotor (LOC) control scores (p = 0.03). Results from a two-way between-groups analysis of variance also revealed no statistically significant interaction effect between PA grouping and physical performance self-concept (PPSC) on overall FMS proficiency levels. Results of a multiple linear regression indicate that perceived PSC is a significant predictor (beta = 0.183) of participants’ overall PA levels. Data show a need for targeting low levels of PA, and low FMS proficiency in female youth, and for developing interventions aiming to enhance perceived PSC levels.
The surveillance of pre-mRNA splicing is an early step in C. elegans RNAi of endogenous genes

Here, Newman et al. provide insight into the role of mRNA splicing in C. elegans RNAi and show that viable null mutations in U1 and U2 snRNP-specific splicing factor genes cause defects in RNAi. They also demonstrate that RNAi targeted transcripts are tightly bound to spliceosomes, which suggests multiple layers of regulation by the spliceosome at early steps of small RNA-mediated gene silencing.
Integrating global and local application of random subspace ensemble

Many data analysis problems involve an investigation of relationships between attributes in heterogeneous databases, where different prediction models can be more appropriate for different regions. We propose a technique of integrating global and local random subspace ensemble. We performed a comparison with other well known combining methods on standard benchmark datasets and the proposed technique gave better accuracy.
UvA-DARE (Digital Academic Repository) Do personality traits affect responsiveness of juvenile delinquents to treatment?

Objective: The aim of the present study was to examine the moderating role of Big Five personality traits in short and long term effectiveness of MultiSystemic Therapy (MST) for serious and persistent juvenile delinquents. Method: Data of a randomized controlled trial ( N = 256) were used to examine the research question. Results: Extraversion, Emotional Stability and Openness did not moderate short term effectiveness of MST, but Conscientiousness and Agreeableness did: MST was most effective for highly conscientious and highly agreeable juvenile delinquents. Personality did not moderate the effectiveness of MST on aggression or the long-term effectiveness of MST. Conclusion: This study shows the importance of personality traits for short-term treatment outcomes, effectiveness of MST differs for high/low Agreeableness and Conscientiousness.
Behind The Dream The Making Of The Speech That Transformed A Nation

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Multimodality Imaging in Restrictive Cardiomyopathies: An EACVI expert consensus document In collaboration with the “Working Group on myocardial and pericardial diseases” of the European Society of Cardiology Endorsed by The Indian Academy of Echocardiography

Restrictive cardiomyopathies (RCMs) are a diverse group of myocardial diseases with a wide range of aetiologies, including familial, genetic and acquired diseases and ranging from very rare to relatively frequent cardiac disorders. In all these diseases, imaging techniques play a central role. Advanced imaging techniques provide important novel data on the diagnostic and prognostic assessment of RCMs. This EACVI consensus document provides comprehensive information for the appropriateness of all non-invasive imaging techniques for the diagnosis, prognostic evaluation, and management of patients with RCM.
Distinct characteristics and outcomes in elderly-onset IgA vasculitis (Henoch-Schönlein purpura) with nephritis: Nationwide cohort study of data from the Japan Renal Biopsy Registry (J-RBR)

Background The clinical presentation and prognosis of adult and elderly patients with IgA vasculitis (Henoch-Schönlein purpura) accompanied by nephritis (IgAV-N) have not been investigated in detail. We therefore surveyed the features and outcomes of IgAV-N based on nationwide data derived from the Japan Renal Biopsy Registry (J-RBR). Methods This multi-center cohort study compared the clinicopathological parameters at diagnosis, initial therapies and outcomes between 106 adult (age 19–64 years) and 46 elderly (≥65 years) patients with IgAV-N who were registered in the J-RBR between 2007 and 2012. The primary end-points comprised a 50% increase in serum creatinine (sCr) values or end-stage kidney disease. Factors affecting a decrease in renal function were assessed using Cox proportional hazards models. Results Rates of hypertension, impaired renal function, hypoalbuminemia and crescentic glomerulonephritis were significantly higher among the elderly, than the adult patients. About 80% and 60% of the patients in both groups were respectively treated with corticosteroid and a renin-angiotensin system (RAS) blockade. Both groups had favorable renal survival rates for nine years (93.6% and 91.4% of the adult and elderly patients, respectively). Significantly more elderly than adult patients developed a 50% increase in sCr during a mean observation period of 3.9 years (21.7% vs. 4.7%, p = 0.012), and significantly fewer elderly, than adult patients achieved clinical remission (23.9% vs. 46.2%, p = 0.016). Multivariate analysis selected advanced age (≥65 years) and lower serum albumin values as independent prognostic factors for a decline in renal function, whereas steroid pulse therapy helped to preserve renal function. Conclusions The renal prognosis of adult and elderly patients with IgAV-N was favorable when treated aggressively with corticosteroid and RAS blockade. However, the course of renal function should be carefully monitored in patients aged over 65 years and those with hypoalbuminemia.
Microscopic Anatomy of the Lower Eyelid in Asians

Purpose: To study the microscopic anatomic relation of the capsulopalpebral fascia, orbital septum, and tarsus of the lower eyelid in Asians. The anatomic differences between the Asian and non-Asian upper eyelid have been well described by various authors, but the differences of the lower eyelid have not been well characterized microscopically. The microscopic anatomy of the lower eyelid in non-Asians was well studied, but in Asians, despite the presence of gross differences, there were very limited studies on the microscopic anatomy. A thorough knowledge of the Asian lower eyelid anatomy is essential for surgical exploration of the eyelid. It may also explain the higher prevalence of eyelid disorders such as epiblepharon and entropion in Asians. Methods: Ten normal Asian lower eyelids from 10 formalin-fixed cadavers (mean age, 67.5 years) were harvested and studied with light microscopy after staining with Masson trichrome. Results: There was no fusion of the orbital septum and the capsulopalpebral fascia at the lower border of the tarsal plate in 7 specimens and a very limited fusion of these tissues in 3 specimens. The average distance from the inferior tarsal border to the first observable smooth muscle nuclei of the inferior retractors was 1.44 mm. The average tarsal plate thickness was 1.36 mm and the average tarsal plate height was 4.12 mm. Conclusions: The Asian lower eyelid anatomy differs from its non-Asian counterpart. There was no consistent fusion between the capsulopalpebral fascia and the orbital septum inferior to the inferior tarsal border. No extension of the capsulopalpebral fascia to the skin was observed. The average distance between the inferior retractors and the inferior tarsal plate was 1.44 mm in the normal Asian lower eyelid.
Novel approach employing buck-boost converter as DC-link modulator and inverter as AC-chopper for induction motor drive applications: An alternative to conventional AC-DC-AC scheme

Induction motor (IM) is the workhorse of the industries. Amongst various speed control schemes for IM, variable-voltage variable-frequency (VVVF) is popularly used. Inverters are broadly used to produce variable/controlled frequency and variable/controlled output voltage for various applications like ac machine drives, switched mode power supply (SMPS), uninterruptible power supplies (UPS), etc. This paper presents the two-fold solution of control for such loads. In this novel solution, rms values of output voltage is varied by controlling the inverter duty ratio which operates as an ac-chopper, while the fundamental frequency of output voltage is varied by controlling the buck-boost converter according to the reference frequency given to it. The buck-boost converter shuffles between buck-mode and boost-mode to produce required frequency by generating the modulated dc-link for the inverter, unlike conventional fixed dc-link in case of ac-dc-ac converters. The proposed technique eliminates overmodulation (as in conventional pulse width modulated inverters) and hence the non-linearity, and lower order harmonics are absent. Further, it reduces dv/dt in the output voltage resulting less stress on the insulation of machine winding, and electromagnetic interference. However, the proposed scheme demands more number of power semiconductor devices as compared to their conventional ac-dc-ac counterparts. Simulation studies of proposed single-phase as well as three-phase topologies are carried out in MATLAB/Simulink. Hardware implementation of proposed single-phase topology is done using dSPACE DS1104 R&D controller board and results are presented.
How Exposure to Air Pollution May Shape Dementia Risk, and What Epidemiology Can Say About It

The number of Americans with Alzheimer ’ s disease (AD) dementia is expected to triple by 2050. No effective treatments exist, and prevention research has focused on behaviors and medical conditions, which have been difficult to modify at the population level. Cardiovascular disease epidemiology can inform the search for AD risk factors; exposure to fine particulate matter (PM) air pollution increases cardiovascular risk, pollutant regulations appear to reduce cardiovascular deaths, and vascular pathology influences dementia risk. In this issue of the Journal , Ailshire and Crimmins ( Am J Epidemiol. 2014;180(4):359 – 366) report analyses of data from 14,000 older adults living across the United States, indicating an inverse association between exposure to PM and cognitive function, an outcome related to AD by virtue of the long period of cognitive decline that precedes clinical disease. Their work joins a growing body of data linking PM exposure to AD risk. If these data reflect causality, PM exposure would be 1 of few AD risk factors that are not only widespread, but that also can be modified at the population level using regulatory intervention. Active collaboration between air pollution and dementia epidemiol-ogists will be critical for refining the available evidence and filling fundamental gaps, including the lack of studies on AD itself.
Predicted Glycerol 3-Phosphate Dehydrogenase Homologs and the Glycerol Kinase GlcA Coordinately Adapt to Various Carbon Sources and Osmotic Stress in Aspergillus fumigatus

Glycerol plays an important role in the adaptation of fungi to various microenvironments and stressors, including heat shock, anoxic conditions and osmotic stress. Glycerol 3-phosphate dehydrogenase (G3PDH) is able to catalyze dihydroxyacetone phosphate to glycerol 3-phosphate (G3P), which is subsequently dephosphorylated into glycerol. However, current knowledge about the functions of G3PDH homologs in glycerol biosynthesis in Aspergillus fumigatus is limited. Here, we show that the A. fumigatus G3PDH gene, gfdA, is crucial for normal colony growth in glucose media under both normoxic and hypoxic conditions. In addition, failure of the overexpression of the gfdA homolog, gfdB, to rescue the phenotype of a gfdA null mutant suggests that gfdA plays a predominant role in the synthesis of G3P and glycerol. However, in a wild-type background, overexpressing either gfdA or gfdB is able to significantly enhance biomass production of mycelia, suggesting that gfdA and gfdB have similar functions in promoting the use of glucose. Interestingly, overexpression of the gene encoding the predicted glycerol kinase, GlcA, which is capable of phosphorylating glycerol to form G3P, significantly rescues the growth defects of gfdA null mutants in glucose media, indicating that the growth defects of gfdA null mutants might be due to the absence of G3P rather than glycerol. Moreover, Western blotting analysis revealed that gfdA is inducibly expressed by osmotic mediators. However, in the absence of gfdA, osmotic stress can rescue colony growth defects and allow colonies to partially bypass the gfdA requirement in a high osmolarity glycerol pathway-dependent manner. Therefore, the findings of this study elucidate how saprophytic filamentous fungi have developed pathways distinct from those of budding yeasts to adapt to varied carbon sources and survive environmental stresses.
The role of chronobiology and circadian rhythms in type 2 diabetes mellitus: implications for management of diabetes

Circadian clocks regulate cellular to organic and individual behavior levels of all organisms. Almost all cells in animals have self-sustained clocks entrained by environmental signals. Recent progress in genetic research has included identification of clock genes whose disruption causes metabolic abnormalities such as diabetes, obesity, and hyperlipidemia. Here we review recent advances in research on circadian disruption, shift work, altered eating behaviors, and disrupted sleep-wake cycles, with reference to management of type 2 diabetes.
Genome-Wide Association Study Identifies Loci and Candidate Genes for Body Composition and Meat Quality Traits in Beijing-You Chickens

Body composition and meat quality traits are important economic traits of chickens. The development of high-throughput genotyping platforms and relevant statistical methods have enabled genome-wide association studies in chickens. In order to identify molecular markers and candidate genes associated with body composition and meat quality traits, genome-wide association studies were conducted using the Illumina 60 K SNP Beadchip to genotype 724 Beijing-You chickens. For each bird, a total of 16 traits were measured, including carcass weight (CW), eviscerated weight (EW), dressing percentage, breast muscle weight (BrW) and percentage (BrP), thigh muscle weight and percentage, abdominal fat weight and percentage, dry matter and intramuscular fat contents of breast and thigh muscle, ultimate pH, and shear force of the pectoralis major muscle at 100 d of age. The SNPs that were significantly associated with the phenotypic traits were identified using both simple (GLM) and compressed mixed linear (MLM) models. For nine of ten body composition traits studied, SNPs showing genome wide significance (P<2.59E−6) have been identified. A consistent region on chicken (Gallus gallus) chromosome 4 (GGA4), including seven significant SNPs and four candidate genes (LCORL, LAP3, LDB2, TAPT1), were found to be associated with CW and EW. Another 0.65 Mb region on GGA3 for BrW and BrP was identified. After measuring the mRNA content in beast muscle for five genes located in this region, the changes in GJA1 expression were found to be consistent with that of breast muscle weight across development. It is highly possible that GJA1 is a functional gene for breast muscle development in chickens. For meat quality traits, several SNPs reaching suggestive association were identified and possible candidate genes with their functions were discussed.
Application of Higuchi Fractal Dimension in Analysis of Heart Rate Variability with Artificial and Natural Noise

I present an example of Higuchi fractal dimension analysis in assessing the response of the cardiovascular system to the administration of a single dose of methadone. I analyze data from 69 patients with opioid-dependent substitution treatment therapy before and after administration of a single dose of methadone. In most cases the fractal dimension increased after administration of methadone ( α = 0.05). This method turned out to be effective in the analysis of non-filtered data with 96% accuracy achieved. This is an example of analysis with random natural noise. In addition, Higuchi fractal dimension analysis is insensitive to artificially added pink noise down to SNR =33dB and white noise down to SNR=40dB . Key-Words: Nonlinear Dynamics, Higuchi Fractal Dimension, HRV, Methadone, Noise
CCAR-1 affects hemidesmosome biogenesis by regulating unc-52/perlecan alternative splicing in the C. elegans epidermis

ABSTRACT Hemidesmosomes are epithelial-specific attachment structures that maintain tissue integrity and resist tension. Despite their importance, how hemidesmosomes are regulated at the post-transcriptional level is poorly understood. Caenorhabditis elegans hemidesmosomes (CeHDs) have a similar structure and composition to their mammalian counterparts, making C. elegans an ideal model for studying hemidesmosomes. Here, we focus on the transcription regulator CCAR-1, identified in a previous genetic screen searching for enhancers of mutations in the conserved hemidesmosome component VAB-10A (known as plectin in mammals). Loss of CCAR-1 function in a vab-10(e698) background results in CeHD disruption and muscle detachment from the epidermis. CCAR-1 regulates CeHD biogenesis, not by controlling the transcription of CeHD-related genes, but by affecting the alternative splicing of unc-52 (known as perlecan or HSPG2 in mammals), the predicted basement extracellular matrix (ECM) ligand of CeHDs. CCAR-1 physically interacts with HRP-2 (hnRNPR in mammals), a splicing factor known to mediate unc-52 alternative splicing to control the proportions of different UNC-52 isoforms and stabilize CeHDs. Our discovery underlines the importance of post-transcriptional regulation in hemidesmosome reorganization. It also uncovers previously unappreciated roles of CCAR-1 in alternative splicing and hemidesmosome biogenesis, shedding new light on the mechanisms through which mammalian CCAR1 functions in tumorigenesis. Summary: Loss of CCAR-1 function during C. elegans embryogenesis results in dysregulated alternative splicing of unc-52 (the homolog of mammalian perlecan) and hemidesmosome disruption.