Miracle-dz/UniFAR-FTUs huggingface dataset:
Treatment of type 2 diabetes in chronic kidney disease: a case for linagliptin in the treatment of diabetes in severe renal impairment

Diabetes is the leading cause of chronic kidney disease, and the prevalence of both diseases is rising worldwide. Treatment of type 2 diabetes is difficult in patients with chronic kidney disease because most oral antidiabetic agents are affected by renal function and their use may be contraindicated in this patient population. Antidiabetic agents that can be used in patients with type 2 diabetes and declining renal function are needed. Incretin-based therapies, such as dipeptidyl peptidase-4 inhibitors, are a recent therapeutic class of glucose-lowering agents that may offer an effective treatment option in patients with chronic kidney disease. Within the dipeptidyl peptidase-4 class, linagliptin has a unique profile with a primarily nonrenal route of elimination, requiring no dose adjustment in patients with chronic kidney disease. This communication summarizes the findings of a 1-year, randomized, double-blind, placebo-controlled study demonstrating the favorable safety and efficacy profile of linagliptin in patients with type 2 diabetes and severe renal impairment.
Correction: "Modularity of the Rankin-Selberg $L$-series, and multiplicity one for SL(2)"

Let f, g be primitive cusp forms, holomorphic or otherwise, on the upper half-plane H of levels N,M respectively, with (unitarily normalized) L-functions L(s, f) = [equation] and L(s, g) = [equation]. When p does not divide N (resp. M), the inverse roots αp, βp (resp. α′p, β′p ) are nonzero with sum ap (resp. bp). For every p prime to NM, set Lp(s, f × g) = [(1 − αpα′pp−s)(1 − αpβ′pp−s)(1 − βpα′pp−s)(1 − βpβ′pp−s)]^−1. Let L∗(s, f × g) denote the (incomplete Euler) product of Lp(s, f × g) over all p not dividing NM. This is closely related to the convolution L-series [sum over n≥1] a[sub]n b[sub] n n^−s, whose miraculous properties were first studied by Rankin and Selberg.
Abrogation of translation initiation factor eIF‐2 phosphorylation causes malignant transformation of NIH 3T3 cells.

The interferon induced double‐stranded RNA‐activated kinase, PKR, has been suggested to act as a tumor suppressor since expression of a dominant negative mutant of PKR causes malignant transformation. However, the mechanism of transformation has not been elucidated. PKR phosphorylates translation initiation factor eIF‐2 alpha on Ser51, resulting in inhibition of protein synthesis and cell growth arrest. Consequently, it is possible that cell transformation by dominant negative PKR mutants is caused by inhibition of eIF‐2 alpha phosphorylation. Here, we demonstrate that in NIH 3T3 cells transformed by the dominant negative PKR mutant (PKR delta 6), eIF‐2 alpha phosphorylation is dramatically reduced. Furthermore, expression of a mutant form of eIF‐2 alpha, which cannot be phosphorylated on Ser51 also caused malignant transformation of NIH 3T3 cells. These results are consistent with a critical role of phosphorylation of eIF‐2 alpha in control of cell proliferation, and indicate that dominant negative PKR mutants transform cells by inhibition of eIF‐2 alpha phosphorylation.
Loosening of the cemented hip prosthesis. The importance of heat injury.

The cemented hip arthroplasty is one of the most successful orthopedic operations. However, the results do deteriorate with time because of mechanical loosening. Some hips with obviously loose prosthetic components are not painful. This discrepancy between symptoms and radiographic evidence of loosening has caused uncertainty about the diagnostic criteria that should be applied. This uncertainty has in turn led to confusion about the basic cause of loosening. The aims of this presentation were to find a favorable definition of loosening and to investigate the etiology of mechanical loosening of the cemented hip prosthesis. The diagnostic criteria of contrast and radionuclide arthrography, bone scintigraphy, and roentgen stereophotogrammetric analysis (RSA) were evaluated in 14 symptomatic hip arthroplasties examined by these methods. Loosening was found to be best defined as migration; regardless of diagnostic criterion, all loose prosthetic components were migrating, but no nonmigrating component was loose. The development of the radiolucent zone was analyzed in a simple model consisting of 6 cases of giant-cell tumor of bone successfully treated by curettage and cementing. In locations where the cement filling adjacent to cancellous bone was concave, a considerably wider zone developed. There was a positive correlation between the width of the zone and the volume of cement. The radiolucent zone in this model could be explained by heat injury during the polymerization of bone cement. The pattern of migration of the components in 20 cemented hip prostheses was studied with RSA and with conventional radiography over a period of 2 years postoperatively. Eleven acetabular and three femoral components migrated. After an initial 4-month period of rapid migration, most components migrated slowly. The initial rapid migration could be accounted for by the resorption of a layer of necrotic bone following heat injury during the polymerization. The less frequent migration of the metallic femoral component as compared with the polyethylene acetabular component could be explained by the metal acting as a heat sink. Radiographic examination was found to be unsatisfactory as a means of detecting mechanical loosening during the first 2 postoperative years. RSA, on the other hand, was capable of revealing migration as early as 4 months postoperatively. Migration of the components in 16 hip prostheses was studied with RSA for 1 year postoperatively following randomized use of low- and high-viscosity cement. As regards prosthetic migration, no difference was detected between the two types of cement; low-viscosity cement did not improve prosthetic fixation. (ABSTRACT TRUNCATED AT 400 WORDS)
Rural area deployment of internet of things connectivity: LTE and LoRaWAN case study

Actually many Internet of Things (IoT) applications and architectures are being deployed in order to support urban area applications, as for example smart cities. However, other important applications are being deployed in rural areas, as for example agribusiness, in which wireless connectivity is one of the most important issues because wireless broadband commercial technologies are not sustainable from the business model view. In order to attend the actual demand of rural areas, the present work proposes two study cases that optimize coverage and low energy consumption joining LTE and LoRaWAN wireless access technologies. The proposal architecture is based on an element called Intelligent Terminal (IT), which is a gateway that is composed by LTE and LoRaWAN interfaces. The first study case represents a terrestrial vehicular case and the second one represents an unmanned aerial vehicle (UAV) case. The terrestrial study case is used as a reference to get a quantified gain of using UAVs. Considering that every scenario has particularities in terrestrial relief characteristics, it was obtained coverage information of five scenarios with different radius. When the radius coverage is increased, usability of UAV becomes more important. In average, for radius equal to 45 km and an UAV height equal to 50 m the gain of using UAVs is equal to 2 times the coverage than using a terrestrial solution. Other important contribution are parameters of a linear equation that estimate the average coverage gain based on any arbitrary UAV altitude.
The Selective Impairment of Phonological Processing in Speech Production

We report the naming performance of a patient (DM) with a fluent progressive aphasia who made phonological errors in all language production tasks. The pattern of errors in naming was strikingly clear: DM made very many phonological errors that resulted almost always in nonword responses. The complete absence of semantic errors and the very low ratio of formal errors relative to nonword errors (1.6:30.3) in DM's performance are discussed in the context of recent claims about the nature of naming deficits in fluent aphasics. We argue that DM's performance makes highly improbable the claim that fluent aphasia results from global lesions affecting all levels of the lexical access system equally.
Ch-Ch-Ch-Changes: Turn and face the strange - Struggles of identity work in organisational change

In today’s fast moving business environment, organisational change is considered a key requisite to remain competitive, however, organisational change can be a double-edged sword as it can create difficulties for individuals in their identity work carried out in the organisation. Moreover, how individuals conduct their identity work in an organisation can amongst other factors be affected by discourse. Previous studies have highlighted the importance of organisational identification in order for individuals to make sense of organisational change, and several researchers have explored the challenges that can arise when there is an established organisational identity in place when seeking to change, as well as moving from one organisational identity to another. However, there is a need for more empirical studies as no previous studies have explored what occurs when moving from an eviscerated organisational identity to an unestablished one. Therefore, our purpose is to explore how a specific organisational change unfolds when there is no established and no envisioned, organisational identity. To investigate this, we chose an interpretative research paradigm and a qualitative research design, whilst taking a reflexive perspective throughout our research. Based within the borders of existing studies on organisational change, organisational discourse, identity and identity work we explore a specific research context, under the pseudonym of Jewellery Co, a leading Swedish retail chain. We followed the organisation for six months during a substantial change process and collected our material through semi-structured interviews, observations, auto-ethnography and by analysing audiovisual materials. We found that within this context, the organisational subcultures became highly dominant, to the degree that the organisational identity was not allowed to emerge, and the individual identity became submerged within the subcultural one. Moreover, we found three dominant discourses which were competing with each other, further enforcing the subcultural dominance. As the organisation under investigation does not have an established organisational identity, or an envisioned one, it creates further challenges in terms of organisational identification, again leading the individuals to identify with the subcultures. Our main finding from this research is that when seeking organisational change, it is important to not underestimate the value of values. If there are no values to identify with, it creates a substantial challenge, if not an impossible one, to manage to change anything at all. Values constitute the organisations very core and what organisational identity is. Organisational members need something persuasive to rally behind, otherwise, it is likely that the change will fail before it even completely begins. (Less)
Fostering a community of practice: Reflections on the evolution of a teacher inquiry group

Introduction A s a university researcher-teacher, I have been privileged to play a role in supporting the work of practitioners i n science and technology education. In this brief report I use several of the ideas proposed Wenger, McDermott, and Synder (2002) on communities of practice to reflect retrospectively on the evolution of a teacher inquiry group, Science Teachers in Action. Wenger (1998) uses the notion of a community of practice as an "entry point into a broader conceptual framework" that focuses on a social theory of learning. In this theory, learning is conceptualized as social participation; people come together to engage actively in the "practices of social communities" and to construct "identities i n relation to these communities" (p. 4). Communities of practice are "groups of people who share a concern, a set of problems, or a passion about a topic, and who deepen their knowledge and expertise i n this area by interacting on an ongoing basis" (Wenger et al., 2002, p. 4). Communities of practice are ubiquitous, and individuals are often members of a variety of these communities. These authors believe that communities of practice can be cultivated through thoughtful attention to creating learning environments that value learning and provide support through resources, time, and the removal of organizational barriers.
Inhibition of growth and increase of acid phosphatase by testosterone on androgen‐independent murine prostatic cancer cells transfected with androgen receptor cDNA

Most androgen‐unresponsive prostatic cancer cells are found to lack androgen receptor (AR). To clarify the role of AR in the process of the progression from androgen‐dependent to androgen‐unresponsive tumor, the AR gene was transfected into an AR‐negative rat prostatic cancer cell line CUB‐II. AR‐transfectant cells expressed AR mRNA and showed binding to R1881. AR was found in nuclei of AR‐transfectant cells by histochemical examination. Therefore, AR‐transfectant cells were considered to contain functional AR. The growth of AR‐transfectant cells was markedly inhibited in culture in the presence of testosterone, and the effect of testosterone was reduced by simultaneous addition of flutamide. Moreover, tumors inoculated with AR‐transfectant cells in male mice showed much slower growth than those in females. The tumors of AR‐transfectant cells in mice consisted of slightly larger spindle‐shaped cells when compared to those of CUB‐II cells. Moreover, AR‐transfectant cells contained a few polynuclear giant cells. Since CUB‐II cells contained acid phosphatase (AcP) activity, the addition of testosterone in culture increased AcP activity of AR‐transfectant cells. It is concluded that resumption of androgen‐dependent processes reduces the growth rate accompanying changes of phenotype. © 1994 Wiley‐Liss, Inc.
An ADHD Diagnostic Approach Based on Binary-Coded Genetic Algorithm and Extreme Learning Machine

An accurate approach for diagnosis of attention deficit hyperactivity disorder (ADHD) is presented in this paper. The presented technique efficiently classifies three subtypes of ADHD (ADHD-C, ADHD-H, ADHD-I) and typically developing control (TDC) by using only structural magnetic resonance imaging (MRI). The research examines structural MRI of the hippocampus from the ADHD-200 database. Each available MRI has been processed by a region-of-interest (ROI) to build a set of features for further analysis. The presented ADHD diagnostic approach unifies feature selection and classification techniques. The feature selection technique based on the proposed binary-coded genetic algorithm searches for an optimal subset of features extracted from the hippocampus. The classification technique uses a chosen optimal subset of features for accurate classification of three subtypes of ADHD and TDC. In this study, the famous Extreme Learning Machine is used as a classification technique. Experimental results clearly indicate that the presented BCGA-ELM (binary-coded genetic algorithm coupled with Extreme Learning Machine) efficiently classifies TDC and three subtypes of ADHD and outperforms existing techniques.
A 1/8-rate clock and data recovery architecture for high-speed communication systems

A new clock and data recovery (CDR) architecture for high-speed communication applications is introduced. The proposed CDR architecture is described in the context of a 40-Gb/s optical communication system. This architecture utilizes 1/8-rate clock to recover and demultiplex the data, and it does not require a frequency divider. Also, the CDR system employs a rate-reduction block to lower the data transition density and thereby alleviates the speed requirements of the data recovery process. For a 40-Gb/s system, the CDR uses a multiphase voltage-controlled oscillator (VCO) with 5-GHz center frequency. The proposed architecture is particularly suitable for deep submicron CMOS designs where the designer encounters difficulties in implementing a full-rate clock and data recovery.
Short-Term Market Timing Using the Bond-Equity Yield Ratio

The Bond-Equity Yield Ratio (BEYR) has recently become a popular relative pricing tool favored by market practitioners. In this paper we compare the short-term profitability of a naive strategy based on the extreme values of the BEYR to the short-term profitability of a more sophisticated strategy relying on regime switches. Although the latter seems to perform better than the former, there is no overwhelming international evidence that these dynamic strategies deliver significantly higher risk-adjusted returns than the buy-and-hold portfolios. In addition, the profitability of these active strategies does not appear to be significantly different when the equity yield, instead of the BEYR, is used as criterion to time the market.
Human Natural Killer Receptors, Co‐Receptors, and Their Ligands

In the last 20 years, the study of human natural killer (NK) cells has moved from the first molecular characterizations of very few receptor molecules to the identification of a plethora of receptors displaying surprisingly divergent functions. Our laboratory has contributed to the description of inhibitory receptors and their signaling pathways, important in fine regulation in many cell types, but unknown until their discovery in the NK cells. Inhibitory function is central to regulating NK‐mediated cytolysis, with different molecular structures evolving during speciation to assure its persistence. Only in the last ten years has it become possible to characterize the NK triggering receptors mediating natural cytotoxicity, leading to an appreciation of the existence of a cellular interaction network between effectors of both natural and adaptive immunity. This report reviews the contemporary history of molecular studies of receptors and ligands involved in NK cell function, characterizing the ligands of the triggering receptor and the mechanisms for finely regulating their expression in pathogen‐infected or tumor cells. Curr. Protoc. Immunol. 84:14.10. 1‐14.10. 40. © 2009 by John Wiley & Sons, Inc.
Des jumeaux et des gènes : l'avenir en psychiatrie génétique

Identifying the genetic basis of human diseases is important for the understanding of their etiology. Although genomic science has achieved considerable progress recently, there remain a number of issues that impede advancement in psychiatric genetics. This article discusses four of these issues, namely the unforeseen genetic and phenotypic complexity of psychiatric disorders, the neglect to take environmental risk factors into account, and the failure to adopt a developmental perspective in genetic studies of mental illness.
Towards non-threaded Concurrent Constraint Programming for implementing multimedia interaction systems

In this work we explain the implementation of event-driven real-time interpreters for the Concurrent Constraint Programming (CCP) and Non-deterministic Timed Concurrent Constraint (NTCC) for- malisms. The CCP interpreter was tested with a program to find, concurrently, paths in a graph and it will be used in the future to find musical sequences in the music improvisation software Omax, developed by the French Acoustics/Music Research Institute (IRCAM). In the other hand, the NTCC interpreter was tested with a music improvisation system based on NTCC (CCFOMI), developed by the AVISPA research group and IRCAM. Additionally, we present GECOL 2, a wrapper for the Generic Constraints Development Environment (GECODE) to Common LISP, de- veloped to port the interpreters to Common LISP in the future. We concluded that using GECODE for the concurrency control avoids the need of having threads and synchronizing them, leading to a simple and efficient implementation of CCP and NTCC. We also noticed that the time units in NTCC interpreter do not represent discrete time units, because when we simulate the NTCC specifications in the interpreter, the time units have different durations. In the future, we propose forcing the duration of each time unit to a fix time, that way we would be able to reason about NTCC time units as we do with discrete time units.
Use of a text grammar for generating highlight abstracts of magazine articles

Browsing a database of article abstracts is one way to select and buy relevant magazine articles online. Our research contributes to the design and development of text grammars for abstracting texts in unlimited subject domains. We developed a system that parses texts based on the text grammar of a specific text type and that extracts sentences and statements which are relevant for inclusion in the abstracts. The system employs knowledge of the discourse patterns that are typical of news stories. The results are encouraging and demonstrate the importance of discourse structures in text summarisation.
NONALCOHOLIC STEATOHEPATITIS AND INSULIN RESISTANCE : INTERFACE BETWEEN GASTROENTEROLOGISTS AND ENDOCRINOLOGISTS

Abstract Nonalcoholic steatohepatitis (NASH), along with other forms of nonalcoholic fatty liver disease, is an increasingly common clinico-pathological syndrome. It is frequently associated with obesity, especially visceral fat, and type 2 diabetes, and is intimately related to markers of the insulin resistance syndrome. Both the prevalence and the severity of liver steatosis are related to body mass index, waist circumference, hyperinsulinaemia, hypertriglyceridaemia and impaired glucose tolerance. The pathophysiology of NASH involves two steps : 1) insulin resistance, which causes steatosis; 2) and oxidative stress, which produces lipid peroxidation and activates inflammatory cytokines. The identification of subjects who may progress from fatty liver to NASH, and from NASH to fibrosis/cirrhosis is an important clinical challenge as well as the finding of appropriate therapy that could prevent such deleterious process. Substantial weight loss is accompanied by a marked attenuation of insulin resistance and related metabolic syndrome and, concomitantly, by an important regression of liver steatosis in most patients, although mild inflammation may be detected in some subjects. Thus, NASH may be considered as another disease of affluence, as is the insulin resistance syndrome and perhaps being part of it.
College Students' Responses to Traumatic Events Involving Sudden Death

The present study investigated undergraduate college students' responses to traumatic death events portrayed in video clips. We extracted a 1-minute clip from Final Destination and a 5-minute clip from Final Destination 2. The control groups viewed either a 1- or 5-minute clip of a nature video. The experimenter administered the DAS (Templer, 1970), before and then immediately following presentation of the videos, to measure any changes in death anxiety. The Myers/Briggs personality questionnaire (Myers & Briggs, 1962) measured personality type, and the Mood Survey (Underwood & Froming, 1980) and Ryburn/Festa Mood Survey measured mood prior to viewing the videos. We analyzed the data and obtained only a significant main effect for video duration. We also obtained a high correlation between the Mood Survey and the Ryburn/Festa Mood Survey.