Miracle-dz/UniFAR-FTUs huggingface dataset:
The γ-glutamyltransferase activity and non-protein sulfhydryl compounds levels in rat kidney of different age groups.

The present work was aimed to obtain information about age-dependent changes of -glutamyltransferase (GGT) activity and the levels of non-protein sulfhydryl compounds (NPSH) in rat kidneys. In addition, protein-bound cysteine (PB-Cys), sulfane sulfur compounds and reactive oxygen species (ROS) were estimated. The results indicate that the activity of GGT and NPSH levels in the kidneys are reduced with age. At the same time, a significant increase in the level of protein-bound cysteine was observed. Simultaneously, the content of sulfane sulfur compounds was increased in the group of the oldest animals. These findings indicate that the capacity for extracellular glutathione degradation and, in consequence, the availability of cysteine for intracellular glutathione biosynthesis may be impaired. The increased PB-Cys level indicates potentiation of the thiolation reaction, i.e. development of protein-mixed disulfides. These results reveal age dependent disturbances in the thiol-disulfide equilibrium in the kidneys which leads to an imbalance between proand antioxidatory processes. The intracellular glutathione (GSH) level depends upon the equilibrium between processes during which it is consumed and its biosynthesis limited by cysteine availability. The metabolism of GSH is closely connected to Meister’s -glutamyl cycle (Meister, 1983)
Metabolic disorders in menopause

Metabolic disorders occurring in menopause, including dyslipidemia, disorders of carbohydrate metabolism (impaired glucose tolerance – IGT, type 2 diabetes mellitus – T2DM) or components of metabolic syndrome, constitute risk factors for cardiovascular disease in women. A key role could be played here by hyperinsulinemia, insulin resistance and visceral obesity, all contributing to dyslipidemia, oxidative stress, inflammation, alter coagulation and atherosclerosis observed during the menopausal period. Undiagnosed and untreated, metabolic disorders may adversely affect the length and quality of women's life. Prevention and treatment preceded by early diagnosis should be the main goal for the physicians involved in menopausal care. This article represents a short review of the current knowledge concerning metabolic disorders (e.g. obesity, polycystic ovary syndrome or thyroid diseases) in menopause, including the role of a tailored menopausal hormone therapy (HT). According to current data, HT is not recommend as a preventive strategy for metabolic disorders in menopause. Nevertheless, as part of a comprehensive strategy to prevent chronic diseases after menopause, menopausal hormone therapy, particularly estrogen therapy may be considered (after balancing benefits/risks and excluding women with absolute contraindications to this therapy). Life-style modifications, with moderate physical activity and healthy diet at the forefront, should be still the first choice recommendation for all patients with menopausal metabolic abnormalities.
Trends in Psychiatry and Psychotherapy Anxiety and Inhibition of Panic Attacks within Translational and Prospective Research Contexts Objectives and Hypothesis

Basic research involving animal models is an important tool to improve our understanding of clinical conditions related with anxiety and panic attacks. In fact, animal models have been used to study several paradigms on analogous and homologous elements of human anxiety phenomena. However, the direct transposition (translation) to clinical practice of the results obtained with animal models may be restricted by the different constructs used to describe and explain empirical evidence of anxiety phenomena among humans. We aimed to analyze whether theoretical assumptions on the potential inhibitory effects of anxiety on panic could be observed among humans in prospective studies designed to analyze the relationship between anxiety and panic. A systematic literature review including papers published in English language between 1997 and 2011 was undertaken on the MEDLINE database. The search yielded a total of 257 articles, of which 11 were included in the review. In three studies, the global dimension of the anxiety sensitivity construct worked as a facilitator of panic attacks. Six studies showed a positive correlation between the AS-Physical Concerns subfactor and the occurrence of panic attacks, whereas two studies found a greater effect of the AS-Mental Incapacitation Concerns subfactor on panic. There was no evidence that anxiety might act as an inhibitor of panic attacks in humans, and there were no conclusive findings on the possibility that any anxiety construct could contribute toward inhibiting panic attacks. In sum, there seems to be a need for refining descriptions of anxious phenomena addressed both in basic preclinical research and in prospective-longitudinal studies involving humans.
Microfabrication and characterization of an array of dielectric elastomer actuators generating uniaxial strain to stretch individual cells

Cells regulate their behavior in response to mechanical strains. Cell cultures to study mechanotransuction are typically cm2 in area, far too large to monitor single cell response. We have developed an array of dielectric elastomer microactuators as a tool to study mechanotransduction of individual cells. The array consists of 72 100 µm × 200 µm electroactive polymer actuators which expand uniaxially when a voltage is applied. Single cells will be attached on each actuator to study their response to periodic mechanical strains. The device is fabricated by patterning compliant microelectrodes on both sides of a 30 µm thick polydimethylsiloxane membrane, which is bonded to a Pyrex chip with 200 µm wide trenches. Low-energy metal ion implantation is used to make stretchable electrodes and we demonstrate here the successful miniaturization of such ion-implanted electrodes. The top electrode covers the full membrane area, while the bottom electrodes are 100 µm wide parallel lines, perpendicular to the trenches. Applying a voltage between the top and bottom electrodes leads to uniaxial expansion of the membrane at the intersection of the bottom electrodes and the trenches. To characterize the in-plane strain, an array of 4 µm diameter aluminum dots is deposited on each actuator. The position of each dot is tracked, allowing displacement and strain profiles to be measured as a function of voltage. The uniaxial strain reaches 4.7% at 2.9 kV with a 0.2 s response time, sufficient to stimulate most cells with relevant biological strains and frequencies.
Balancing User and System Control in Shape-Changing Interfaces: a Designerly Exploration

Despite an increasing number of examples of shape-changing interfaces, the relation between users' actions and product movements has not gained a great deal of attention, nor been very well articulated. This paper presents a framework articulating the level of control offered to the user over the shape change. The framework considers whether the shape change is: 1) directly controlled by the user's explicit interactions; 2) negotiated with the user; 3) indirectly controlled by the users actions; 4) fully controlled by the system. The four types are described through design examples using ReFlex, a shape-changing interface in the form of a smartphone. The paper concludes that shape-changing interfaces tend to assign the control to either the user or the underlying system, while few (e.g. [16,28]) consider sharing the control between the user and the system.
Spectral detection on sparse hypergraphs

We consider the problem of the assignment of nodes into communities from a set of hyperedges, where every hyperedge is a noisy observation of the community assignment of the adjacent nodes. We focus in particular on the sparse regime where the number of edges is of the same order as the number of vertices. We propose a spectral method based on a generalization of the non-backtracking Hashimoto matrix into hypergraphs. We analyze its performance on a planted generative model and compare it with other spectral methods and with Bayesian belief propagation (which was conjectured to be asymptotically optimal for this model). We conclude that the proposed spectral method detects communities whenever belief propagation does, while having the important advantages to be simpler, entirely nonparametric, and to be able to learn the rule according to which the hyperedges were generated without prior information.
Original and Normalized Web Log Metrics as Functions of Controllable Variables of Log Study

Different studies of Web search engine query logs calculate the same metrics using logs sampled during different periods and processed under different values of two controllable variables: a client discriminator used to exclude clients who are agents and a temporal cutoff used to segment client transactions into sessions. These peculiar to the Web log analysis variables markedly affect the resulting metrics, and metrics calculated under different values of the variables may not be compared directly. To extract a contribution of the controllable variables we introduce metrics normalized by their values corresponding to the unit values of the variables. Whilst differences between values of the original metric may be enormous among different logs, normalized metrics are relatively similar functions of the controllable variables. As a result, one can use available logs as a learning collection to determine these functions and to use them to approximate metrics values for unavailable logs by reported values of metrics and controllable variables. The Yandex (2005, 2007) and Excite (2001) logs were used as a learning collection to estimate log-free normalized metrics as functions of the controllable variables. The revealed functions were applied to previously reported AltaVista (1998, 2002) results to extrapolate values reported for one combination of controllable variables onto all possible combinations of variables.
TOWARDS TESTING THE INTEGRATION OF MOF/UML-BASED DOMAIN-SPECIFIC MODELING LANGUAGES

Domain-specific modeling languages (DSMLs) are commonly employed in the model-driven development (MDD) of software systems. As DSMLs are tailored for a narrow application domain, a software system needs to integrate multiple DSMLs for its complete specification. In this paper, we review the suitability of selected testing techniques for each phase of an MOF/UML-based DSML integration process. We exemplify every test technique by providing a motivating example of its application to the composition of existing, security-related DSMLs. As for evaluation, we provide for prototypical software implementations.
THE ULTRAVIOLET IMAGING TELESCOPE: INSTRUMENT AND DATA CHARACTERISTICS

The Ultraviolet Imaging Telescope (\UIT) was flown as part of the \AstroMiss\ observatory on the Space Shuttle Columbia in December 1990 and again on the Space Shuttle Endeavor in March 1995. Ultraviolet (1200-3300Å) images of a variety of astronomical objects, with a 40\arcmin\ field of view and a resolution of about 3\arcsec, were recorded on photographic film. The data recorded during the first flight is available to the astronomical community through the National Space Science Data Center (NSSDC); the data recorded during the second flight will soon be available as well. This paper discusses in detail the design, operation, data reduction, and calibration of \UIT, providing the user of the data with information for understanding and using the data. It also provides guidelines for analyzing other astronomical imagery made with image intensifiers and photographic film.
Grooming down the hierarchy : Allogrooming in captive brown capuchin monkeys

Parr, L. , Matheson, M. , Bernstein, I. and de Waal, F. 1997. Grooming down the hierarchy: Allogrooming in captive brown capuchin monkeys, Cebus apella. Anim. Behav. 54: 361–367. Perry, S. and Rose, L. 1994. Begging and transfer of coati meat by white-faced capuchin monkeys, Cebus capucinus. Primates 35(4): 409–415. Perry, S. 1998. Male-male social relationships in wild white-faced capuchins, Cebus capucinus. Behaviour 135 (2): 139–142. Robinson, J. 1986. Seasonal variation in use of time and space by the wedge-capped capuchin monkeys, Cebus olivaceus: Implications for foraging theory. Smithson. Contrib. Zool. (431): 1–60. Rose, L. 1997. Vertebrate predation and food-sharing in Cebus and Pan. Int. J. Primatol. 18: 727–765. Visalberghi, E. and McGrew, W. 1997. Cebus meets Pan. Int. J. Primatol. 18: 677–681.
Changes in the Medicare Home Health Care Market: The Impact of Reimbursement Policy

Background:The Balanced Budget Act of 1997 introduced 2 new reimbursement structures, the Interim Payment System (IPS, 1997–2000) and the Prospective Payment System (PPS, begun October 2000) for Medicare home health agencies (HHAs) under the fee-for-service program. Objective:This article describes and compares the impact of these changes on the Medicare home health market from a period before the BBA through the IPS and PPS in relation to agency characteristics. Research Design:A secondary analysis of 1996, 1999, and 2002 Provider of Services data was conducted on all Medicare-certified HHAs. Frequencies and rates of change were calculated by agency characteristics to describe changes in the number of active agencies through those years. Logistic regression models were used to compare factors associated with market exits under different payment systems. Results:The results indicate dramatic but disproportional changes in response to the IPS and the PPS among Medicare home health care agencies. Agency closures were greater and market entries fewer during the IPS, but more branch offices/subunits were closed during the PPS. Proprietary and freestanding agencies experienced greater volatility throughout, with the greatest number of closures seen in Region VI (Dallas). Conclusions:These results demonstrate the direct impact of policy changes on the home health care market and highlight the need to evaluate policy changes to understand both intended and unintended impacts on health markets. Future research should analyze the effect of these policy changes on other healthcare providers and systems and their impact on health outcomes for Medicare beneficiaries.
Comparative assessment of open source software using easy accessible data

Open source (usually free of charge) software has become increasingly prominent in last few years. Previous research of software being developed under open source license has showed, that some open source products can reach qualitative and popularity level of commercial (usually closed-source) counterparts. However, a lot of open source software do not attain maturity. This shows that their projects have problems and that the quality of projects outcomes (software) can vary. Therefore an assessment model is necessary which could filter out only suitable (qualitative) products. This paper presents a quantitative basis for evaluating an open source product based on multiple criteria of software quality. In contrary to other software assessment models, which are time-consuming and expensive, the proposed model uses easy accessible quantitative data, specific for open source projects. A set of measurements for evaluating open source software together with proposed model and a practical example is presented
Some histochemical features of anther wall of Leucojum aestivum (Amaryllidaceae) during pollen development

In this study, polysaccharide and RNA contents of anthers were investigated on different phases of sporogenesis by using light microscopy techniques from histological and cytological point of view in Leucojum aestivum. Paraffin and semi-thin sections of anthers were stained with toluidine blue and PAS. Anthers were tetrasporangiate. The wall of the anther consists of an epidermis, endothecium, middle layer and glandular tapetum. During one nucleated microspore and mature pollen phase microspores and tapetum cells began to degenerate and they were become very rich of RNA in L. aestivum. And also RNA content was increased in endothecium and middle layer cells except the epidermis cells of anther wall. An increase in RNA content indicates cell activation. Polysaccharides were not seen in young anther wall but they were seen in older ones. They were generally condensed in the cell walls and especially in the cell walls of vascular bundles of connective tissue. This could be thought that insoluble polysaccharides were used in metabolic events in early developmental stages. Appearance of polysaccharides in late phases was indicated that polysaccharides were used in the formation of cuticule and differentiation of endothelium cell walls.
A TRAINED SEGMENTATION TECHNIQUE FOR OPTIMIZATION OF OBJECT-ORIENTED CLASSIFICATION

: Along with the significant improvement of spatial resolution of remote sensing imagery in the recent years, traditional per-pixel based classification techniques have been facing increasing problems in achieving acceptable classification results. Object-oriented classification has become a promising alternative for classifying high-resolution remote sensing imagery, such as QuickBird, Ikonos or airborne digital multispectral images. In object-oriented classification, object segmentation is a crucial process. It significantly influences the classification efficiency and accuracy. However, current state-of-the-art techniques heavily rely on the operator’s experience to achieve a proper segmentation through a labour-intensive and time-consuming trail-and-error process. The accuracy of the classification is often influenced by the experience of the operator. This paper presents a trained segmentation technique for reducing the tedious trail-and-error process of object segmentation and improving classification accuracy. A segmentation optimizer is developed based on fuzzy logic techniques, which can determine optimal object segmentation parameters to achieve a most appropriate segmentation of individual objects. Instead of trail and error, the operator just needs to apply an initial segmentation to the input image and then use the initial segments of objects of interest to train the segmentation optimizer. After the training the segmentation optimizer can then identify most suitable object segmentation parameters. Finally, these parameters are used to segment objects in the entire input image, achieving an optimal segmentation of all objects of interest. Testing results demonstrated that the segmentation optimizer can significantly improve the process efficiency and classification accuracy, when it is integrated into a state-of-the-art object-oriented classification system.
Research on the Effectiveness of Exercise Therapy Treating MentalIllness

With the development of modern society, mental illness has become a high incidence of all illnesses. This paper describes the positive role of sport in the rehabilitation of mental illness played from exercise physiology and psychology. And for the various manifestations of mental illness, introduce a number of specific exercise therapies. Finally, we chose 10 student volunteers as our experiment subjects. After one week of exercise therapy, compared the mental state indexes of before and after motion treatment. The final results showed that exercise therapy can significantly improve the psychological status of college students.
RNA Editing and Drug Discovery for Cancer Therapy

RNA editing is vital to provide the RNA and protein complexity to regulate the gene expression. Correct RNA editing maintains the cell function and organism development. Imbalance of the RNA editing machinery may lead to diseases and cancers. Recently, RNA editing has been recognized as a target for drug discovery although few studies targeting RNA editing for disease and cancer therapy were reported in the field of natural products. Therefore, RNA editing may be a potential target for therapeutic natural products. In this review, we provide a literature overview of the biological functions of RNA editing on gene expression, diseases, cancers, and drugs. The bioinformatics resources of RNA editing were also summarized.
Effect of Licorice on Wound Healing In Rabbits

Licorice (Glycyrrhiza glabra) is one of the most widely used medicinal plants and is included in numerous traditional and modern medical preparations. In the present study the healing effect of licorice extract was investigated on open skin wounds in rabbits. Adult Newzeland rabbits of both sexes weighing 1.5 - 2.5 kg were used. Hairs of lower back and left flank of animal were shaved. Full-thickness wound (15x15 mm) was made on the shaved area. Hydroalcoholic extract of licorice was prepared by maceration method. Creams of 5%, 10% and 15% (w/w) extract in eucerin base were prepared and applied 2 times daily. Dexpanthenol ointment was used as standard control. Healing was determined by reduction in wound area. The results of this study proved that licorice cream of 10% was a potent healing agent even better than dexpanthenol cream.
Enhancing Clustering Algorithm to Plan Efficient Mobile Network

ABSTRACT With the rapid development in mobile network effective network planning tool is needed to satisfy the need of customers. However, deciding upon the optimum placement for the base stations (BS) to achieve best services while reducing the cost is a complex task requiring vast computational resource. This paper addresses antenna placement problem or the cell planning problem, involves locating and configuring infrastructure for mobile networks. The Cluster Partitioning Around Medoids (PAM) original algorithm has been modified and a new algorithm M-PAM (Modified-Partitioning Around Medoids) has been proposed by the authors in a recent work. In the present paper, the M-PAM algorithm is modified and a new algorithm CWN-PAM (Clustering with Weighted Node-Partitioning Around Medoids) has been proposed to satisfy the requirements and constraints. Implementation of this algorithm to a real case study is presented. Results demonstrate the effectiveness and flexibility of the modifying algorithm in tackling the important problem of mobile network planning.
Linearized gravity in the Randall-Sundrum scenario

In the literature about the Randall-Sundrum scenario, one finds, on the one hand, that there exist (small) corrections to Newton's law of gravity on the brane and, on the other, that the exact (and henceforth linearized) Einstein equations can be recovered on the brane. The explanation for these seemingly contradictory results is that the behavior of the bulk far from the brane is different in both models. We show that explicitly in this paper.
Asymmetric classifier based on kernel PLS for imbalanced data

In classification tasks, class imbalance problem has been reported to hinder the performance of some standard classifiers, such as nearest neighbors algorithm. This paper presents an improvement to kernel partial least squares classifier (KPLSC) is proposed to deal with the class imbalance problem. This improvement is applicable to all cases no matter whether the data sets are linearly separable or not. Experiments on datasets from different domains show that the improvement performs well in classification problems.