Miracle-dz/UniFAR-FTUs huggingface dataset:
Field Analysis of Stepwise Effective Thermal Conductivity along a Borehole Heat Exchanger under Artificial Conditions of Groundwater Flow

Heat advection caused by groundwater flow can potentially improve the performance of a borehole heat exchanger. However, the required flow velocity is not achieved under most natural conditions. This study focuses on artificial groundwater flow generated by pumping and investigates the associated effect in a lowland area near the Toyohira River alluvial fan, Sapporo, Japan. Thermal response test results are compared under natural and artificial groundwater flow conditions. A pumping well is constructed one meter from the borehole. Temperature profiles are measured in the U-tube during testing, using a pair of optic fiber distributed temperature sensors. The effective thermal conductivity is calculated from the profiles obtained in each 10-m sub-layer; this thermal conductivity is termed the stepwise thermal conductivity. Additionally, the upward flow velocity in the pumping well is measured to estimate the mean groundwater flow velocity at the borehole. The results show that effective thermal conductivity increases at depths less than 50 m, where the pumping creates mean velocities greater than 0.1 m d−1 in each sub-layer (1.5 md−1 on average). Thus, a borehole length of 50 m is more reasonable at the test site for its efficiency in a ground source heat pump system coupled with the pumping well than that used.
Commuting Variability by Wage Groups in Baton Rouge, 1990–2010

ABSTRACT Residential segregation has recently shifted to become more class- and income-based in the United States, and neighborhoods have undergone significant changes in commuting patterns over time. To better understand the commuting pattern across neighborhoods of different income levels, this research analyzes commuting variability (in both distance and time) across wage groups as well as stability over time using the Census Transportation Planning Package (CTPP) data for 1990 through 2010 in Baton Rouge, Louisiana. In comparison to previous work, commuting distance is estimated more accurately by Monte Carlo simulation of individual trips to mitigate aggregation error and scale effect. The results based on neighborhood's mean wage rate indicate that commuting behavior varies across areas of different wage rates and such variability is captured by a convex relationship. Affluent neighborhoods tended to commute more, but the highest wage neighborhoods displayed a reduced level of commuting. This trend remains relatively stable over time despite a general overall transportation improvement. An exploratory analysis based on the distribution of wage groups is conducted to gain more detailed insights and uncovers the lasting poor mobility (e.g., fewer location and transport options) of the lowest wage workers between 1990 and 2010.
Effects of SARS-CoV-2 infection on health and functional capacity in institutionalized older adults

ABSTRACT Objective: To assess the effect of SARS-CoV-2 infection on the health conditions and functional capacity of older adults living in long-term care units in Maceió City – Alagoas State. Methods: A prospective cohort was conducted with institutionalized older adults of both sexes. Older adults were assessed for clinical conditions (diagnosis of chronic diseases and biochemical tests), functional capacity, and nutritional status. All assessments were repeated on two occasions, maintaining a 6-month interval between them. Results: The sample was composed of 289 older adults. Of the total, 98 (33.9%) were positive for COVID-19 and eight died (2.8%). Men were more likely to have COVID-19 (OR = 3.50; p < 0.01). It was observed that the disease contributed to increasing the frequency of dependent older adults after six months (OR = 1.38; p-interaction < 0.01). It was also observed that after six months of positive diagnosis for COVID-19, there was greater weight loss (p < 0.01), reduced BMI (p < 0.01), increased mean SBP (p = 0.04), and DBP (p = 0.03). Conclusion: Effects of COVID-19 in institutionalized older adults go beyond acute complications and compromise blood pressure control, functional capacity, and favor weight loss.
Performance and oncologic safety of sentinel lymph node biopsy after neoadjuvant chemotherapy: Results from a tertiary care center in Lebanon

Abstract Background The feasibility of sentinel lymph node biopsy (SLNB) after neoadjuvant chemotherapy (NACT) in initially node‐positive patients is still controversial. We aim to evaluate the oncologic outcomes of SLNB after NACT and further compare the results between those who were initially node‐negative and node‐positive. Methods This is a retrospective cohort that included patients diagnosed with invasive breast cancer and had surgical management between January 2010 and December 2016. Survival and recurrence data after 3–5 years were collected from patients' records. We divided patients into Group A who were initially node‐negative and had SLNB ± axillary lymph node dissection (ALND) and Group B who were node‐positive and had SLNB ± ALND. Results Among initially node‐negative patients, 43 out of 63 patients did SLNB (Group A). However, among initially node‐positive patients only 28 out of 123 patients did SLNB (Group B). Out of the 71 patients who did SLNB after NACT, 26 patients had positive SLNs with only 14 patients who further underwent ALND. The identification rate of SLNB was 100% in Group A and 96.4% in Group B. The survival curves by nodal status showed no significant difference between overall survival and recurrence‐free survival at 5 years between patients in Group A versus Group. Conclusion The results suggest that in properly selected patients, SLNB can be feasible after NACT. Our results resemble the reported literature on accuracy of SLNB after NACT and adds to the growing pool of data on this topic.
Malaria in the Amazon: An Agent-Based Approach to Epidemiological Modeling of Coupled Systems

The epidemiology of malaria considers a complex set of local interactions amongst host, vector, and environment. A history of reemergence, epidemic transition, and ensuing endemic transmission in Iquitos, Peru reveals an interesting case used to model and explore such interactions. In this region of the Peruvian Amazon, climate change, development initiatives and landscape fragmentation are amongst a unique set of local spatial variables underlying the endemicity of malaria. Traditional population-based approaches lack the ability to resolve the spatial influences of these variables. Presented is a framework for spatially explicit, agent-based modeling of malaria transmission dynamics in Iquitos and surrounding areas. The use of an agent-based model presents a new opportunity to spatially define causal factors and influences of transmission between mosquito vectors and human hosts. In addition to spatial considerations, the ability to model individual decisions of humans can define socio-economic and human-environment interactions related to malaria transmission. Three interacting sub-models representing human decisions, vector dynamics, and environmental factors comprise the model. Feedbacks between the interacting sub-models define individual decisions and ultimately the flexibility that will allow the model to function in a diagnostic capacity. Sensitivity analysis and simulated interactions are used to discuss this diagnostic capability and to build understanding of the physical systems driving local transmission of malaria.
Primary Astrocytes Purification and Immortalization

Astrocytes, the most abundant cells in the central nervous system (CNS), are essential for neuronal development, network formation, and overall CNS homeostasis. Primary astrocyte culture has been successfully used as a tool to study astrocyte biology in vitro. In the present protocol, a modified immunopanning method was utilized to obtain and purify primary astrocytes from mouse cortex and spinal cord in a relatively quick and inexpensive way. Purified primary astrocytes were then immortalized through infection of lentivirus expressing the SV40 large T antigens. In addition, we provide protocols to determine the expression levels of astrocyte‐specific markers and to perform functional studies measuring the ATP‐induced calcium flux in the immortalized astrocytes. Following the described protocols assures that the immortalized astrocytes that one prepares mimic the cell biology of primary astrocytes in culture. Thus, the purification and immortalization protocols for primary astrocytes presented in here provide two models for the studies of astrocyte biology and may be useful for the immortalization of other types of primary cells. © 2023 Wiley Periodicals LLC.
Protection of the third-dose and fourth-dose mRNA vaccines against SARS-CoV-2 Omicron subvariant: a systematic review and meta-analysis

Objectives The rapid spread of the SARS-CoV-2 Omicron variant has raised concerns regarding waning vaccine-induced immunity and durability. We evaluated protection of the third-dose and fourth-dose mRNA vaccines against SARS-CoV-2 Omicron subvariant and its sublineages. Design Systematic review and meta-analysis. Data sources Electronic databases and other resources (PubMed, Embase, CENTRAL, MEDLINE, CINAHL PLUS, APA PsycINFO, Web of Science, Scopus, ScienceDirect, MedRxiv and bioRxiv) were searched until December 2022. Study eligibility criteria We included studies that assessed the effectiveness of mRNA vaccine booster doses against SARS-CoV-2 infection and severe COVID-19 outcomes caused by the subvariant. Data extraction and synthesis Estimates of vaccine effectiveness (VE) at different time points after the third-dose and fourth-dose vaccination were extracted. Random-effects meta-analysis was used to compare VE of the third dose versus the primary series, no vaccination and the fourth dose at different time points. The certainty of the evidence was assessed by Grading of Recommendations, Assessments, Development and Evaluation approach. Results This review included 50 studies. The third-dose VE, compared with the primary series, against SARS-CoV-2 infection was 48.86% (95% CI 44.90% to 52.82%, low certainty) at ≥14 days, and gradually decreased to 38.01% (95% CI 13.90% to 62.13%, very low certainty) at ≥90 days after the third-dose vaccination. The fourth-dose VE peaked at 14–30 days (56.70% (95% CI 50.36% to 63.04%), moderate certainty), then quickly declined at 61–90 days (22% (95% CI 6.40% to 37.60%), low certainty). Compared with no vaccination, the third-dose VE was 75.84% (95% CI 40.56% to 111.12%, low certainty) against BA.1 infection, and 70.41% (95% CI 49.94% to 90.88%, low certainty) against BA.2 infection at ≥7 days after the third-dose vaccination. The third-dose VE against hospitalisation remained stable over time and maintained 79.30% (95% CI 58.65% to 99.94%, moderate certainty) at 91–120 days. The fourth-dose VE up to 60 days was 67.54% (95% CI 59.76% to 75.33%, moderate certainty) for hospitalisation and 77.88% (95% CI 72.55% to 83.21%, moderate certainty) for death. Conclusion The boosters provided substantial protection against severe COVID-19 outcomes for at least 6 months, although the duration of protection remains uncertain, suggesting the need for a booster dose within 6 months of the third-dose or fourth-dose vaccination. However, the certainty of evidence in our VE estimates varied from very low to moderate, indicating significant heterogeneity among studies that should be considered when interpreting the findings for public health policies. PROSPERO registration number CRD42023376698.
The effects of high‐intensity exercise training and detraining with and without active recovery on postexercise hypotension in young men

Whether high‐intensity exercise training and detraining combined with skeletal muscle pump (MP) could alter the magnitude of postexercise hypotension has not been investigated. We therefore sought to determine whether the combination of MP (unloaded back‐pedaling) with 4 weeks of high‐intensity exercise training and detraining could alter the magnitude of postexercise hypotension. Fourteen healthy men underwent 4 weeks of high‐intensity exercise training (5 consecutive days per week for 15 min per session at 40% of the difference between the gas exchange threshold and maximal oxygen uptake [i.e., Δ40%]) followed by detraining for 4 weeks. Assessments were conducted at Pre‐training (Pre), Post‐training (Post) and after Detraining with (MP) and without MP (Con). The exercise test in the Pre, Post and the Detraining consisted of 15 min exercise at Δ40% followed by 1 h of recovery. At all time‐points, the postexercise reduction in mean arterial pressure (MAP) was reduced in MP compared to Con (all p < 0.01). Four weeks of high‐intensity exercise training resulted in a reduction in the magnitude of postexercise hypotension (i.e., the change in MAP from baseline was mitigated) across both trials (All p < 0.01) when compared to Pre and Detraining. Following Detraining, the reduction of MAP from baseline was reduced compared to Pre, but was not different from Post. We conclude that high‐intensity exercise training combined with skeletal MP reduces the magnitude of postexercise hypotension, and this effect is partially retained for 4 weeks following the complete cessation of high‐intensity exercise training.
Cost-effectiveness of occupational therapy for older adults: a protocol for an updated systematic review

Introduction The ageing populations in developed countries are a global concern, with increasing numbers of older adults facing physical, cognitive and psychological challenges, resulting in reduced quality of life and higher healthcare costs. Healthcare expenditure worldwide has been on the rise, especially among older adults, emphasising the importance of enabling independent living while reducing healthcare costs. Occupational therapy holds promising outcomes in promoting functional independence and enhancing the quality of life for older adults, but research on its cost-effectiveness remains limited. This systematic review aims to evaluate the recent evidence on the cost-effectiveness of occupational therapy interventions for older adults from a pragmatic perspective. Methods and analysis This systematic review will cover full economic evaluations, including cost-effectiveness, cost-utility and cost–benefit analyses, by reviewing randomised and cluster randomised controlled trials. The participants will be aged over 65 years without disease or disability restrictions. Primary outcomes will be assessed using functional status and quality-of-life assessments. Studies published before July 2023 will be searched in PubMed, Web of Science and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases, with no language restrictions. Ethics and dissemination Ethical approval is not required for this literature-based systematic review. The study’s findings will update the evaluation of occupational therapy’s cost-effectiveness in older adults and will be made public by publishing them in scholarly journals. PROSPERO registration number CRD42023453558.
Drosophila ribosomal protein S5b is essential for oogenesis and interacts with distinct RNAs

In Drosophila melanogaster there are two genes encoding ribosomal protein S5, RpS5a and RpS5b. Here, we demonstrate that RpS5b is required for oogenesis. Females lacking RpS5b produce ovaries with numerous developmental defects that undergo widespread apoptosis in mid-oogenesis. Females lacking germline RpS5a are fully fertile, but germline expression of interfering RNA targeting germline RpS5a in an RpS5b mutant background worsened the RpS5b phenotype and blocked oogenesis before egg chambers form. A broad spectrum of mRNAs co-purified in immunoprecipitations with RpS5a, while RpS5b-associated mRNAs were specifically enriched for GO terms related to mitochondrial electron transport and cellular metabolic processes. Consistent with this, RpS5b mitochondrial fractions are depleted for proteins linked to oxidative phosphorylation and mitochondrial respiration, and RpS5b mitochondria tended to form large clusters and had more heterogeneous morphology than those from controls. We conclude that RpS5b-containing ribosomes preferentially associate with particular mRNAs and serve an essential function in oogenesis.
Emotions and Narrative Reappraisal Strategies of Users of Breast Cancer Screening: Reconstructing the Past, Passing Through the Present, and Predicting Emotions

Emotional forecasting, meaning how a person anticipates feeling as a consequence of their choices, drives healthcare decision-making. Research, however, suggests that people often do not fully anticipate or otherwise grasp the future emotional impacts of their decisions. Emotional reappraisal strategies, such as putting emotions into words and sharing emotions with others, may mitigate potential undesirable effects of emotions on decision-making. The use of such strategies is important for consequential decisions, such as obtaining timely mammography screening for breast cancer, whereby earlier diagnosis may impact the success of treatment. In this study, we explored the use of emotional reappraisal strategies for decision-making regarding breast cancer screening attendance among women aged 50–69 years. Data were collected through semi-structured interviews following mammography with a reflexive thematic methodological approach employed for analysis. Results shed light on how participants’ emotional response narratives were reconstructed before the mammography, felt during the mammography, and forecasted while awaiting the results. Future research should consider how individuals experience and manage their emotions as they access breast screening services.
Objectives, objects, and objectivity: On practitioner–academic collaboration in tourism and leisure research

In the area of tourism management, the previous research shows that collaboration among stakeholders is crucial in achieving or aspiring toward sustainable development because the field is highly fragmented with numerous stakeholders constituting the tourism product. In a single-case study, the analytical concept of boundary objects is used to show that not only the human relationships but also the objects created and used in such collaborations must be considered to understand how such collaboration can influence sustainable tourism practices. The results show the importance of such objects in becoming part of everyday practices and thereby support a sustained collaboration. Additionally, the results indicate that the creation of boundary objects can contribute to a reduced focus on consensus, and therefore, the professional integrity of the parties involved can be maintained.
Additive genetic variance for lifetime fitness and the capacity for adaptation in an annual plant

The immediate capacity for adaptation under current environmental conditions is directly proportional to the additive genetic variance for fitness, VA(W). Mean absolute fitness, , is predicted to change at the rate , according to Fisher’s Fundamental Theorem of Natural Selection. Despite ample research evaluating degree of local adaptation, direct assessment of VA(W) and the capacity for ongoing adaptation is exceedingly rare. We estimated VA(W) and in three pedigreed populations of annual Chamaecrista fasciculata, over three years in the wild. Contrasting with common expectations, we found significant VA(W) in all populations and years, predicting increased mean fitness in subsequent generations (0.83 to 6.12 seeds per individual). Further, we detected two cases predicting “evolutionary rescue”, where selection on standing VA(W) was expected to increase fitness of declining populations ( < 1.0) to levels consistent with population sustainability and growth. Within populations, interannual differences in genetic expression of fitness were striking. Significant genotype-by-year interactions reflected modest correlations between breeding values across years (all r < 0.490), indicating temporally variable selection at the genotypic level; that could contribute to maintaining VA(W). By directly estimating VA(W) and total lifetime , our study presents an experimental approach for studies of adaptive capacity in the wild.
Supply Chain Coordination in the Presence of Gray Markets and Strategic Consumers

The practice of diverting genuine products to unauthorized gray markets continues to challenge companies in various industries and creates intense competition for authorized channels. Recent industry surveys report that the abuse of channel incentives is a primary reason for the growth of gray market activities. Therefore, it is crucial that companies take the presence of gray markets into consideration when they design contracts to distribute products through authorized retailers. This issue has received little attention in the extensive literature on contracting and supply chain coordination. In this study, we analyze the impacts of gray markets on two classic contracts, wholesale price and quantity discount, in a supply chain with one manufacturer and one retailer when the retailer has the opportunity to sell to a domestic gray market. Our analysis provides interesting and counterintuitive results. First, a classic quantity‐discount contract that normally coordinates the supply chain can perform so poorly in the presence of a gray market that the supply chain would be better off using a wholesale price contract instead. Second, the presence of gray market can also degrade the performance of the wholesale price contract; therefore, a more sophisticated contract is needed for coordinating the supply chain. We show that contracts that solely depend on retailer's order quantity cannot coordinate the supply chain, and provide the conditions for coordinating the supply chain with price‐dependent quantity discount contracts. We also provide comparative statics and show that when there is a gray market, coordinating the supply chain enhances total consumer welfare.
The Trajectory Interval Forest Classifier for Trajectory Classification

GPS devices generate spatio-temporal trajectories for different types of moving objects. Scientists can exploit them to analyze migration patterns, manage city traffic, monitor the spread of diseases, etc. Many current state-of-the-art models that use this data type require a not negligible running time to be trained. To overcome this issue, we propose the Trajectory Interval Forest (TIF) classifier, an efficient model with high throughput. TIF works by calculating various mobility-related statistics over a set of randomly selected intervals. These statistics are used to create a tabular representation of the data, which can be used as input for any classical classifier. Our results show that TIF is comparable to or better than state-of-art in terms of accuracy and is orders of magnitude faster.