Miracle-dz/UniFAR-FTUs huggingface dataset:
Nitrous oxide emissions during establishment of eight alternative cellulosic bioenergy cropping systems in the North Central United States

Greenhouse gas (GHG) emissions from soils are a key sustainability metric of cropping systems. During crop establishment, disruptive land‐use change is known to be a critical, but under reported period, for determining GHG emissions. We measured soil N2O emissions and potential environmental drivers of these fluxes from a three‐year establishment‐phase bioenergy cropping systems experiment replicated in southcentral Wisconsin (ARL) and southwestern Michigan (KBS). Cropping systems treatments were annual monocultures (continuous corn, corn–soybean–canola rotation), perennial monocultures (switchgrass, miscanthus, and poplar), and perennial polycultures (native grass mixture, early successional community, and restored prairie) all grown using best management practices specific to the system. Cumulative three‐year N2O emissions from annuals were 142% higher than from perennials, with fertilized perennials 190% higher than unfertilized perennials. Emissions ranged from 3.1 to 19.1 kg N2O‐N ha−1 yr−1 for the annuals with continuous corn > corn–soybean–canola rotation and 1.1 to 6.3 kg N2O‐N ha−1 yr−1 for perennials. Nitrous oxide peak fluxes typically were associated with precipitation events that closely followed fertilization. Bayesian modeling of N2O fluxes based on measured environmental factors explained 33% of variability across all systems. Models trained on single systems performed well in most monocultures (e.g., R2 = 0.52 for poplar) but notably worse in polycultures (e.g., R2 = 0.17 for early successional, R2 = 0.06 for restored prairie), indicating that simulation models that include N2O emissions should be parameterized specific to particular plant communities. Our results indicate that perennial bioenergy crops in their establishment phase emit less N2O than annual crops, especially when not fertilized. These findings should be considered further alongside yield and other metrics contributing to important ecosystem services.
Sustainable Diets and Biodiversity: Directions and Solutions for Policy, Research and Action. International Scientific Symposium, Biodiversity and Sustainable Diets United Against Hunger, FAO Headquarters, Rome, Italy, 3-5 November 2010.

It is time to face the evidence of a worldwide unsustainable food system. Its complexity makes it extremely fragile to any climatic, socio-economic, political or financial crisis. Thus, we urgently need appropriate understanding and new strategies to really accommodate present and future population needs and well-being. In that context, we need sustainable diets, with low-input, local and seasonal agro-ecological food productions as well as shortdistance production-consumption nets for fair trade. Cultural heritage, food quality and culinary skills are other key aspects determining sustainable dietary patterns and food security. Nutrition education about appropriate food choices remains essential everywhere. It thus appears very urgent to profoundly change our food strategy and to promote fair, culturally-appropriated, biodiversity-based, ecofriendly, sustainable diets. Authorities should urgently assume their responsibilities by orienting and supporting the appropriate and sustainable foodstuff productions and consumptions in all parts of the world.
A vision system for UAV position control

In this paper, we propose a vision-based control system for the localization of an unmanned aerial vehicle (UAV) which equips on-board cameras. 1 2The proposed approach is combined a visual odometer with inertial measurement from IMU and pressure signal which compensate attitude and altitude, respectively. For the autonomous control of a UAV, we consider only natural landmarks provided by a feature tracking algorithm without the help of visual beacons or landmarks at known positions. The displacement of the UAV is estimated by the homography, the relationship between a pair of points. The experimental results show that it is possible to extract useful position information from the proposed vision system even when the UAV flies high, and the information can be used temporary position control of UAVs during GPS failure.
Predictors for efficacy of percutaneous mitral valve repair using the MitraClip system: the results of the MitraSwiss registry

Background Percutaneous mitral valve repair (MVR) using the MitraClip system has become a valid alternative for patients with severe mitral regurgitation (MR) and high operative risk. Objective To identify clinical and periprocedural factors that may have an impact on clinical outcome. Design Multi-centre longitudinal cohort study. Setting Tertiary referral centres. Patients Here we report on the first 100 consecutive patients treated with percutaneous MVR in Switzerland between March 2009 and April 2011. All of them had moderate–severe (3+) or severe (4+) MR, and 62% had functional MR. 82% of the patients were in New York Heart Association (NYHA) class III/IV, mean left ventricular ejection fraction was 48% and the median European System for Cardiac Operative Risk Evaluation was 16.9%. Interventions MitraClip implantation performed under echocardiographic and fluoroscopic guidance in general anaesthesia. Main outcome measures Clinical, echocardiographic and procedural data were prospectively collected. Results Acute procedural success (APS, defined as successful clip implantation with residual MR grade ≤2+) was achieved in 85% of patients. Overall survival at 6 and 12 months was 89.9% (95% CI 81.8 to 94.6) and 84.6% (95% CI 74.7 to 91.0), respectively. Univariate Cox regression analysis identified APS (p=0.0069) and discharge MR grade (p=0.03) as significant predictors of survival. Conclusions In our consecutive cohort of patients, APS was achieved in 85%. APS and residual discharge MR grade are important predictors of mid-term survival after percutaneous MVR.
Dynamic System Adaptation by Constraint Orchestration

For Paradigm models, evolution is just-in-time specified coordination conducted by a special reusable component McPal. Evolution can be treated consistently and on-the-fly through Paradigm’s constraint orchestration, also for originally unforeseen evolution. UML-like diagrams visually supplement such migration, as is illustrated for the case of a critical section solution evolving into a pipeline architecture. 1 Problem Situation Software systems are large and complex. However, more strikingly, software systems have a strong tendency to grow over time, both in size and complexity. In order to deal with size and complexity, software architectures are used. A software architecture provides a global description of an actually far more detailed software system by giving an overview in terms of components and links. Components are the main relevant parts, links are the relevant connections between them.
VARICOSE, a WD-domain protein, is required for leaf blade development

To gain insight into the processes controlling leaf development, we characterized an Arabidopsis mutant, varicose (vcs), with leaf and shoot apical meristem defects. The vcs phenotype is temperature dependent; low temperature growth largely suppressed defects, whereas high growth temperatures resulted in severe leaf and meristem defects. VCS encodes a putative WD-domain containing protein, suggesting a function involving protein-protein interactions. Temperature shift experiments indicated that VCS is required throughout leaf development, but normal secondary vein patterning required low temperature early in leaf development. The low-temperature vcs phenotype is enhanced in axr1-3 vcs double mutants and in vcs mutants grown in the presence of polar auxin transport inhibitors, however, vcs has apparently normal auxin responses. Taken together, these observations suggest a role for VCS in leaf blade formation.
Cortical mechanisms of sensory learning and object recognition

Learning about the world through our senses constrains our ability to recognise our surroundings. Experience shapes perception. What is the neural basis for object recognition and how are learning-induced changes in recognition manifested in neural populations? We consider first the location of neurons that appear to be critical for object recognition, before describing what is known about their function. Two complementary processes of object recognition are considered: discrimination among diagnostic object features and generalization across non-diagnostic features. Neural plasticity appears to underlie the development of discrimination and generalization for a given set of features, though tracking these changes directly over the course of learning has remained an elusive task.
Listeria monocytogenes Invades the Epithelial Junctions at Sites of Cell Extrusion

Listeria monocytogenes causes invasive disease by crossing the intestinal epithelial barrier. This process depends on the interaction between the bacterial surface protein Internalin A and the host protein E-cadherin, located below the epithelial tight junctions at the lateral cell-to-cell contacts. We used polarized MDCK cells as a model epithelium to determine how L. monocytogenes breaches the tight junctions to gain access to this basolateral receptor protein. We determined that L. monocytogenes does not actively disrupt the tight junctions, but finds E-cadherin at a morphologically distinct subset of intercellular junctions. We identified these sites as naturally occurring regions where single senescent cells are expelled and detached from the epithelium by extrusion. The surrounding cells reorganize to form a multicellular junction that maintains epithelial continuity. We found that E-cadherin is transiently exposed to the lumenal surface at multicellular junctions during and after cell extrusion, and that L. monocytogenes takes advantage of junctional remodeling to adhere to and subsequently invade the epithelium. In intact epithelial monolayers, an anti-E-cadherin antibody specifically decorates multicellular junctions and blocks L. monocytogenes adhesion. Furthermore, an L. monocytogenes mutant in the Internalin A gene is completely deficient in attachment to the epithelial apical surface and is unable to invade. We hypothesized that L. monocytogenes utilizes analogous extrusion sites for epithelial invasion in vivo. By infecting rabbit ileal loops, we found that the junctions at the cell extrusion zone of villus tips are the specific target for L. monocytogenes adhesion and invasion. Thus, L. monocytogenes exploits the dynamic nature of epithelial renewal and junctional remodeling to breach the intestinal barrier.
Cellular basis for the ECG features of the LQT1 form of the long-QT syndrome: effects of beta-adrenergic agonists and antagonists and sodium channel blockers on transmural dispersion of repolarization and torsade de pointes.

BACKGROUND This study examines the cellular basis for the phenotypic appearance of broad-based T waves, increased transmural dispersion of repolarization (TDR), and torsade de pointes (TdP) induced by beta-adrenergic agonists under conditions mimicking the LQT1 form of the congenital long-QT syndrome. METHODS AND RESULTS A transmural ECG and transmembrane action potentials from epicardial, M, and endocardial cells were recorded simultaneously from an arterially perfused wedge of canine left ventricle. Chromanol 293B, a specific IKs blocker, dose-dependently (1 to 100 micromol/L) prolonged the QT interval and action potential duration (APD90) of the 3 cell types but did not widen the T wave, increase TDR, or induce TdP. Isoproterenol 10 to 100 nmol/L in the continued presence of chromanol 293B 30 micromol/L abbreviated the APD90 of epicardial and endocardial cells but not that of the M cell, resulting in widening of the T wave and a dramatic accentuation of TDR. Spontaneous as well as programmed electrical stimulation (PES)-induced TdP was observed only after exposure to the IKs blocker and isoproterenol. Therapeutic concentrations of propranolol (0.5 to 1 micromol/L) prevented the actions of isoproterenol to increase TDR and to induce TdP. Mexiletine 2 to 20 micromol/L abbreviated the APD90 of M cells more than that of epicardial and endocardial cells, thus diminishing TDR and the effect of isoproterenol to induce TdP. CONCLUSIONS This experimental model of LQT1 indicates that a deficiency of IKs alone does not induce TdP but that the addition of beta-adrenergic influence predisposes the myocardium to the development of TdP by increasing transmural dispersion of repolarization, most likely as a result of a large augmentation of residual IKs in epicardial and endocardial cells but not in M cells, in which IKs is intrinsically weak. Our data provide a mechanistic understanding of the cellular basis for the therapeutic actions of beta-adrenergic blockers in LQT1 and suggest that sodium channel block with class IB antiarrhythmic agents may be effective in suppressing TdP in LQT1, as they are in LQT2 and LQT3, as well as in acquired (drug-induced) forms of the long-QT syndrome.
MULTI-SCALE SIMULATIONS OF STIRRED LIQUID -- LIQUID DISPERSIONS

Direct numerical simulations (DNS) of liquid -liquid dispersions in a three-dimensional periodic domain have been performed by means of the lattice -Boltzmann method. The dis- persion was agitated by a random force field such as to produce isotropic turbulence. The turbu- lence levels and its history were based on a fluid parcel in a turbulently stirred tank traversing the impeller swept region. The DNS provide detailed insight in the coalescence and break-up events brought about by the turbulent flow, the evolution of the drop size distribution in time, and the interaction of the small-scale flow and the droplets as witnessed in terms of the spectral charac- teristics of the turbulence.
Challenges in creating an opt-in biobank with a registrar-based consent process and a commercial EHR

Residual clinical samples represent a very appealing source of biomaterial for translational and clinical research. We describe the implementation of an opt-in biobank, with consent being obtained at the time of registration and the decision stored in our electronic health record, Epic. Information on that decision, along with laboratory data, is transferred to an application that signals to biobank staff whether a given sample can be kept for research. Investigators can search for samples using our i2b2 data warehouse. Patient participation has been overwhelmingly positive and much higher than anticipated. Over 86% of patients provided consent and almost 83% requested to be notified of any incidental research findings. In 6 months, we obtained decisions from over 18 000 patients and processed 8000 blood samples for storage in our research biobank. However, commercial electronic health records like Epic lack key functionality required by a registrar-based consent process, although workarounds exist.
Collaboratively constructed knowledge repositories as a resource for domain independent concept extraction

To achieve a domain independent text management, a flexible and adaptive knowledge repository is indispensable and represents the key resource for solving many challenges in natural language processing. Especially for real world applications, the needed resources cannot be provided for technical disciplines, like engineering in the energy or the automotive domain. We therefore propose in this paper, a new approach for knowledge (concept) acquisition based on collaboratively constructed knowledge repositories like Wikipedia and enterprise Wikis.
Coherent UWB Ranging in the Presence of Multiuser Interference

Roundtrip time-of-arrival (ToA) measurements employing ultra-wideband (UWB) signals can provide high-precision ranging information. However, the accuracy is degraded by multiuser interference (MUI), in particular in the presence of multipath propagation. While the processing gain of time-hopping impulse radio (TH-IR) can be used to suppress the MUI, this is often insufficient. We propose instead a nonlinear processing scheme of TH-IR that effectively suppresses MUI without requiring knowledge of the time-hopping sequences of the interfering users. The principle is that multipath components (MPCs) of interferers do not align closely, for the majority of transmission frames, with the MPCs of the desired signal. Through a judicious choice of algorithm parameters we show that our algorithm is superior to existing (realizable) thresholding and median filter algorithms, and in some cases can even beat genie-aided thresholding algorithms. The performance is robust to both strength and number of the interferers. The results are validated with both standardized 802.15. 4a channel models and measured outdoor UWB channels.
Model Based Inversion for Deriving Maps of Histological Parameters Characteristic of Cancer From Ex-Vivo Multispectral Images of the Colon

A model-based inversion method was used to obtain quantitative estimates of histological parameters from multispectral images of the colon and to examine their potential for discriminating between normal and pathological tissues. Pixel-wise estimates of the mucosal blood volume fraction, density of the scattering particles and thickness were derived using a two-stage method. In the first (forward) stage reflectance spectra corresponding to given instances of the parameter values were computed using Monte Carlo simulation of photon propagation through a multi-layered tissue. In the second (inversion) stage the parameter values were obtained via optimization using an iterated conditional modes algorithm based on Discrete Markov Random Fields. The method was validated on computer generated data contaminated with noise giving a mean normalized root mean square deviation (NRMSD) of 2.04. Validation on ex vivo images demonstrated that parametric maps show gross correspondence with histological features of mucosa characteristic of cancerous, precancerous and noncancerous colon lesions. The key signs of abnormality were shown to be the increase in the blood volume fraction and decrease in the density of scattering particles.
Space-ecology set covering problem for modeling Daiyun Mountain Reserve, China

Site selection is an important issue in designing the nature reserve that has been studied over the years. However, a well-balanced relationship between preservation of biodiversity and site selection is still challenging. Unlike the existing methods, we consider three critical components, the spatial continuity, spatial compactness and ecological information to address the problem of designing the reserve. In this paper, we propose a new mathematical model of set covering problem called Space-ecology Set Covering Problem (SeSCP) for designing a reserve network. First, we generate the ecological information by forest resource investigation. Then, we split the landscape into elementary cells and calculate the ecological score of each cell. Next, we associate the ecological information with the spatial properties to select a set of cells to form a nature reserve for improving the ability of protecting the biodiversity. Two spatial constraints, continuity and compactability, are given in SeSCP. The continuity is to ensure that any selected site has to be connected with adjacent sites and the compactability is to minimize the perimeter of the selected sites. In computational experiments, we take Daiyun Mountain as a study area to demonstrate the feasibility and effectiveness of the proposed model.
Micro-ultrasound for preclinical imaging

Over the past decade, non-invasive preclinical imaging has emerged as an important tool to facilitate biomedical discovery. Not only have the markets for these tools accelerated, but the numbers of peer-reviewed papers in which imaging end points and biomarkers have been used have grown dramatically. High frequency ‘micro-ultrasound’ has steadily evolved in the post-genomic era as a rapid, comparatively inexpensive imaging tool for studying normal development and models of human disease in small animals. One of the fundamental barriers to this development was the technological hurdle associated with high-frequency array transducers. Recently, new approaches have enabled the upper limits of linear and phased arrays to be pushed from about 20 to over 50 MHz enabling a broad range of new applications. The innovations leading to the new transducer technology and scanner architecture are reviewed. Applications of preclinical micro-ultrasound are explored for developmental biology, cancer, and cardiovascular disease. With respect to the future, the latest developments in high-frequency ultrasound imaging are described.
Testability of product data management interfaces

The Testability of Interaction-Driven Manufacturing Systems project seeks to enhance the design-fortestability of specifications for manufacturing software interfaces, derive a test method that is usable for interaction-driven manufacturing systems in general, and foster the reuse of testing artifacts. For our first testability study we constructed some prototype conformance and interoperability tests for the Product Data Management Enablers standard from the Object Management Group. We reused test data developed for the Product Data Management Schema, a developing standard based on ISO 10303 (informally known as the Standard for Exchange of Product model data), and enumerated the lessons learned for testing and testability. We plan to reuse some of our new testing artifacts for testing an ISO 10303 Standard Data Access Interface to data based on the Product Data Management Schema. (
AN EPLS MODEL FOR A VARIABLE PRODUCTION RATE WITH STOCK-PRICE SENSITIVE DEMAND AND DETERIORATION

It is observed that large piles of consumer goods displayed in supermarkets lead consumers to buy more, which generates more profit to sellers. But a large number of on-hand display of stock leaves a negative impression on the buyer. Also, the amount of shelf or display space is limited. Due to this reason, we impose a restriction on the number of on-hand display of stock and also on initial and ending on-hand stock levels. We introduce an economic production lot size model, where production rate depends on stock and selling price per unit. A constant fraction deterioration rate is considered in this model. To illustrate the results of the model, four numerical examples are established. Sensitivity analysis of the changes of parameter values is also given.
Terms of use : Click here Sperner ' s Theorem and a Problem of Erdős , Katona and Kleitman

A central result in extremal set theory is the celebrated theorem of Sperner from 1928, which gives the size of the largest family of subsets of [n] not containing a 2-chain, F 1 ⊂ F 2. Erd˝ os extended this theorem to determine the largest family without a k-chain, F 1 ⊂ F 2 ⊂ · · · ⊂ F k. Erd˝ os and Katona, followed by Kleitman, asked how many chains must appear in families with sizes larger than the corresponding extremal bounds. In 1966, Kleitman resolved this question for 2-chains, showing that the number of such chains is minimized by taking sets as close to the middle level as possible. Moreover, he conjectured the extremal families were the same for k-chains, for all k. In this paper, making the first progress on this problem, we verify Kleitman's conjecture for the families whose size is at most the size of the k + 1 middle levels. We also characterize all extremal configurations.