Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Zinc Oxide on the Morphology and Mechanical Properties of Poly(Styrene-co-Acrylonitrile)/Poly(Methyl Methacrylate)/Zinc Oxide Composites

The effect of zinc oxide (ZnO) on the morphology and mechanical properties of poly(styrene-coacrylonitrile) (SAN) and poly(methyl methacrylate) (PMMA) blends was investigated. Composites of blends of SAN and PMMA (20/80 wt%) with ZnO were prepared by melt mixing in a twin screw extruder and then the composites were molded by compression molding method. The dispersion of ZnO particles in the matrix polymers was investigated using SEM. It was observed that the dispersion of ZnO particles was relatively good with low ZnO content but the aggregates of ZnO particles in a polymer matrix increased with increasing ZnO content. The mechanical test showed that the tensile strength and stress at break of SAN/PMMA blends decreased slightly with increasing ZnO content. Increasing content of ZnO up to 1.0 wt% increasing the Young’s modulus and impact strength of SAN/PMMA blends while the addition of ZnO beyond 1.0 wt% decreased the Young’s modulus and impact strength.
Experimental ochratoxicosis in turkey poults.

Graded concentrations of ochratoxin A (0, 1, 2, 4, and 8 micrograms/g of feed) incorporated into the diet of turkey poults from hatching until 3 weeks of age resulted in a decreased growth rate, enlarged proventriculus and gizzard, and a regressed thymus (all at 4 and 8 micrograms/g) and the sizes of liver, spleen, pancreas, kidneys, bursa of Fabricius were unaffected. Feed conversion ratio increased from 1.63 (control value) to 2.07 (8 micrograms/g). Mortality was increased significantly (P less than .05) at 8 micrograms/g. Water consumption and plasma uric acid were increased at 4 and 8 micrograms/g. Plasma glucose and the dry weight of the kidneys decreased significantly at 8 micrograms/g while total plasma proteins, prothrombin time, plasma carotenoids, and phenol red clearance rate were unaltered. A leucocytopenia, which was primarily a lymphocytopenia, was observed at 4 and 8 micrograms/g. Heterophils decreased while basophils increased at 8 micrograms/g. The oral LD50 for day-old and 3-week-old poults was 4.63 +/- . 31 and 7.84 +/- . 94 mg/kg, respectively. Intraperitoneally, the value for day-old birds was . 16 +/- . 03 +/- mg/kg and for 3-week-old birds was . 34 +/- . 09 mg/kg. These data suggest that ochratoxin is a potent nephrotoxin in turkeys, but that ochratoxicosis in turkeys differs markedly from the disease in other species.
The Effect of Instruction Padding on SFI Overhead

Software-based fault isolation (SFI) is a technique to isolate a potentially faulty or malicious software module from the rest of a system using instruction-level rewriting. SFI implementations on CISC architectures, including Google Native Client, use instruction padding to enforce an address layout invariant and restrict control flow. However this padding decreases code density and imposes runtime overhead. We analyze this overhead, and show that it can be reduced by allowing some execution of overlapping instructions, as long as those overlapping instructions are still safe according to the original per-instruction policy. We implemented this change for both 32-bit and 64-bit x86 versions of Native Client, and analyzed why the performance benefit is higher on 32-bit. The optimization leads to a consistent decrease in the number of instructions executed and savings averaging 8.6% in execution time (over compatible benchmarks from SPECint2006) for x86-32. We describe how to modify the validation algorithm to check the more permissive policy, and extend a machine-checked Coq proof to confirm that the system's security is preserved.
High-pitch dual-source CT angiography without ECG-gating for imaging the whole aorta: intraindividual comparison with standard pitch single-source technique without ECG gating.

PURPOSE We aimed to perform intraindividual comparison of computed tomography (CT) parameters, image quality, and radiation exposure between standard CT angiography (CTA) and high-pitch dual source (DS)-CTA, in subjects undergoing serial CTA of thoracoabdominal aorta. METHODS Eighteen subjects with thoracoabdominal CTA by standard technique and high-pitch DS-CTA technique within 6 months of each other were retrieved for intraindividual comparison of image quality in thoracic and abdominal aorta. Quantitative analysis was performed by comparison of mean aortic attenuation, noise, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR). Qualitative analysis was performed by visual assessment of motion artifacts and diagnostic confidence. Radiation exposure was quantified by effective dose. Image quality was apportioned to radiation exposure by means of figure of merit. RESULTS Mean aortic attenuation and noise were higher in high-pitch DS-CTA of thoracoabdominal aorta, whereas SNR and CNR were similar in thoracic aorta and significantly lower in high-pitch DS-CTA of abdominal aorta (P = 0.024 and P = 0.016). High-pitch DS-CTA was significantly better in the first segment of thoracic aorta. Effective dose was reduced by 72% in high-pitch DS-CTA. CONCLUSION High-pitch DS-CTA without electrocardiography-gating is an effective technique for imaging aorta with very low radiation exposure and with significant reduction of motion artifacts in ascending aorta; however, the overall quality of high-pitch DS-CTA in abdominal aorta is lower than standard CTA.
Modulation of host plant immunity by Tobamovirus proteins

Background To establish successful infection, plant viruses produce profound alterations of host physiology, disturbing unrelated endogenous processes and contributing to the development of disease. In tobamoviruses, emerging evidence suggests that viral‐encoded proteins display a great variety of functions beyond the canonical roles required for virus structure and replication. Among these, their modulation of host immunity appears to be relevant in infection progression. Scope In this review, some recently described effects on host plant physiology of Tobacco mosaic virus (TMV)‐encoded proteins, namely replicase, movement protein (MP) and coat protein (CP), are summarized. The discussion is focused on the effects of each viral component on the modulation of host defense responses, through mechanisms involving hormonal imbalance, innate immunity modulation and antiviral RNA silencing. These effects are described taking into consideration the differential spatial distribution and temporality of viral proteins during the dynamic process of replication and spread of the virus. Conclusion In discussion of these mechanisms, it is shown that both individual and combined effects of viral‐encoded proteins contribute to the development of the pathogenesis process, with the host plant's ability to control infection to some extent potentially advantageous to the invading virus.
Adaptations with Intermittent Exercise Training in Post- and Premenopausal Women

Introduction The purposes of the present study was to examine the effect of intermittent exercise training on musculoskeletal and metabolic health in postmenopausal (PM) and premenopausal (PRM) women and, furthermore, to evaluate whether the adaptations can be maintained with a reduced training frequency. Methods Eighteen PM (51 ± 1 yr, mean ± SEM) and 12 PRM (48 ± 1 yr) women participated in floorball training approximately two times per week for 12 wk. In a subgroup (n = 9) of PM women (PM40), exercise training was performed for an additional 40 wk with a reduced training frequency of approximately one training session per week. Results In PM, the body fat percentage decreased (P < 0.05) and the total lean leg mass increased (P < 0.05) during the 12-wk training period, with no changes in PRM. In both PM and PRM, lean body mass and maximal oxygen uptake (V˙O2max) were higher, and Yo-Yo intermittent endurance test 1 (YYIET-1) performance was better (P < 0.05) after the 12-wk training period. Procollagen type 1 amino-terminal propeptide was higher (P < 0.05) in PM, and total leg bone mineral density (BMD) was higher (P < 0.05) in both PM and PRM after the 12-wk training period. In PM40, total lean leg mass, V˙O2max, YYIET-1 performance, level of procollagen type 1 amino-terminal propeptide, and total leg BMD were maintained, whereas whole-body BMD and glycated hemoglobin (HbA1c) were reduced (P < 0.05) and the expression of muscle glucose transporter type 4 was higher (P < 0.05). Conclusion Twelve weeks of intermittent exercise training increased BMD, intermittent exercise capacity, and V˙O2max in PM and PRM, with PM also having positive changes in body composition. Additional 40 wk of training with a reduced frequency was sufficient to preserve these physiological adaptations and also improve blood glucose regulation in PM.
How do we manage blood product support in the massively hemorrhaging obstetric patient?

Obstetric hemorrhage remains a leading cause of maternal mortality with more than 140,000 deaths annually worldwide. Abnormal placentation has increased to become the most common diagnosis requiring massive blood transfusion in obstetrics, with uterine atony a close second. At our institution, as well as nationwide, there has been a steady increase in pregnancies complicated by abnormal placentation, including accreta, increta, and percreta. Providers at our facility created the New England Center for Placental Disorders in May 2015 to address these complex patients. The incidence of accreta has actually increased 10‐fold over the past 50 years, becoming the most common reason for cesarean hysterectomy in highly industrialized countries. The most common risk factor for accreta is repeat cesarean sections, particularly those with associated placenta previa. Contemporary cesarean section rates have risen, with more than 1.2 million women having had a cesarean section in the United States in 2014. We present a case vignette of a multiparous woman presenting with heavy vaginal bleeding at 30 weeks' gestation with imaging concerning for placenta accreta and possible percreta. We describe our approach to the management of these complicated patients.
Synergistic effect of β-amyloid and neurodegeneration on cognitive decline in clinically normal individuals.

IMPORTANCE Assessing the ability of Alzheimer disease neuroimaging markers to predict short-term cognitive decline among clinically normal (CN) individuals is critical for upcoming secondary prevention trials using cognitive outcomes. OBJECTIVE To determine whether neuroimaging markers of β-amyloid (Aβ) and neurodegeneration (ND) are independently or synergistically associated with longitudinal cognitive decline in CN individuals. DESIGN, SETTING, AND PARTICIPANTS Academic medical center longitudinal natural history study among 166 CN individuals (median age, 74 years; 92 women). MAIN OUTCOMES AND MEASURES The Aβ status was determined with Pittsburgh Compound B-positron emission tomography, while ND was assessed using 2 a priori measures, hippocampus volume (magnetic resonance imaging) and glucose metabolism (positron emission tomography with fludeoxyglucose F 18), extracted from Alzheimer disease-vulnerable regions. Based on imaging markers, CN individuals were categorized into the following preclinical Alzheimer disease stages: stage 0 (Aβ-/ND-), stage 1 (Aβ(+)/ND-), stage 2 (Aβ(+)/ND(+)), and suspected non-Alzheimer disease pathology (Aβ-/ND(+)). Cognition was assessed with a composite of neuropsychological tests administered annually. RESULTS The Aβ(+) CN individuals were more likely to be classified as ND+: 59.6% of Aβ(+) CN individuals were ND(+), whereas 31.9% of Aβ- CN individuals were ND(+) (odds ratio, 3.14; 95% CI, 1.44-7.02; P = .004). In assessing longitudinal cognitive performance, practice effects were evident in CN individuals negative for both Aβ and ND, whereas diminished practice effects were observed in CN individuals positive for either Aβ or ND. Decline over time was observed only in CN individuals positive for both Aβ and ND, and decline in this group was significantly greater than that in all other groups (P < .001 for all). A significant interaction term between Aβ and ND confirmed that this decline was greater than the additive contributions of Aβ and ND (P = .04). CONCLUSIONS AND RELEVANCE The co-occurrence of Aβ and ND accelerates cognitive decline in CN individuals. Therefore, both factors are important to consider in upcoming secondary prevention trials targeting CN individuals at high risk for progression to the symptomatic stages of Alzheimer disease.
Cinema as large as life: Large-scale light field cinema system

Movie theaters have amazed and entertained humanity for over a hundred years through the combination of art and science known as cinematography. While the conventional 2D motion pictures are still the leading contents of cinemas, there is a notable rise in the number of movies being shown in 3D stereoscopic format. However, in the mean time, the presence of stereoscopic television is reclining and new forms of visualizations are emerging, such as glasses-free 3D technologies. The research efforts of the recent years made light field visualization viable and commercially available. In this paper, we introduce a large-scale light field cinema system, implementation of which is already executable in the present day. The aim of this paper is to highlight the scalability of such systems and demonstrate its capabilities through the parameters of a real-life 3D movie theater.
Acceleration patterns of the head and pelvis during gait in older people with Parkinson's disease: a comparison of fallers and nonfallers.

BACKGROUND Falls are common in older people with Parkinson's disease (PD) and are likely to be related to gait disturbances associated with the condition. Although several studies have evaluated differences in basic gait parameters in people with PD, none have directly evaluated the stability of the upper body during gait. METHODS Temporospatial gait parameters and acceleration patterns at the head and pelvis were measured in three groups of older people: 33 controls without PD (mean age 67 +/- 4 years), 33 older people with PD and no history of falls (mean age 63 +/- 4 years), and 33 older people with PD and a history of falls (mean age 67 +/- 2 years). Harmonic ratios of head and pelvis accelerations in each plane were calculated to provide an indicator of upper body stability. RESULTS Compared with the control group, older people with PD exhibited significantly reduced walking speed and step length and increased step timing variability. Acceleration patterns were also significantly less rhythmic at the head and pelvis in all three planes. After adjusting for differences in walking speed and step timing variability, PD fallers exhibited significantly less rhythmic accelerations at the pelvis in the vertical and anteroposterior planes than PD nonfallers. CONCLUSIONS Acceleration patterns during gait differ between older people with and without PD and between older people with PD who do and do not fall. These findings suggest that an inability to control displacements of the torso when walking may predispose older people with PD to falls.
Selective maternal seeding and environment shape the human gut microbiome

Vertical transmission of bacteria from mother to infant at birth is postulated to initiate a life-long host-microbe symbiosis, playing an important role in early infant development. However, only the tracking of strictly defined unique microbial strains can clarify where the intestinal bacteria come from, how long the initial colonizers persist, and whether colonization by other strains from the environment can replace existing ones. Using rare single nucleotide variants in fecal metagenomes of infants and their family members, we show strong evidence of selective and persistent transmission of maternal strain populations to the vaginally born infant and their occasional replacement by strains from the environment, including those from family members, in later childhood. Only strains from the classes Actinobacteria and Bacteroidia, which are essential components of the infant microbiome, are transmitted from the mother and persist for at least 1 yr. In contrast, maternal strains of Clostridia, a dominant class in the mother's gut microbiome, are not observed in the infant. Caesarean-born infants show a striking lack of maternal transmission at birth. After the first year, strain influx from the family environment occurs and continues even in adulthood. Fathers appear to be more frequently donors of novel strains to other family members than receivers. Thus, the infant gut is seeded by selected maternal bacteria, which expand to form a stable community, with a rare but stable continuing strain influx over time.
Preliminary Study of the Role F-Box Protein 32 (FBXO32) in Colorectal Neoplasms Through the Transforming Growth Factor beta (TGF-β)/Smad4 Signalling Pathway

Background F-box protein 32 (FBXO32) (also known as atrogin-1), a member of the F-box protein family, was recently shown to be a transforming growth factor beta (TGF-β)/Smad4 target gene involved in regulating cell survival. It can be transcriptionally silenced by epigenetic mechanisms in some cancers, but its role in colorectal carcinoma (CRC) is unclear. We investigated the role of FBXO32 in CRC and determined its prognostic significance. Material/Methods We used real-time quantitative PCR, Western blot, and immunohistochemistry to elucidate the role of FBXO32 in clinical specimens and primary CRC cell lines. Differences in patient survival were determined by the Kaplan-Meier method and log-rank test. Results We found that the FBXO32 and SMAD4 levels were higher in normal tissues than in CRC tissues, but PAI-1 and VEGF levels showed the opposite pattern. The expressions of FBXO32 and SMAD4 were related to clinicopathological parameters in CRC. Kaplan-Meier analyses showed that the 5-year overall survival of the low-FBXO32 expression group was significantly shorter than that of the high-FBXO32 expression group (p=0.010). Conclusions The fbxo32 gene is a novel tumor suppressor that inhibits CRC progression by inducing differentiation. Elevated expression of FBXO32 predicts longer survival in CRC patients.
Identifying Malaria Transmission Foci for Elimination Using Human Mobility Data

Humans move frequently and tend to carry parasites among areas with endemic malaria and into areas where local transmission is unsustainable. Human-mediated parasite mobility can thus sustain parasite populations in areas where they would otherwise be absent. Data describing human mobility and malaria epidemiology can help classify landscapes into parasite demographic sources and sinks, ecological concepts that have parallels in malaria control discussions of transmission foci. By linking transmission to parasite flow, it is possible to stratify landscapes for malaria control and elimination, as sources are disproportionately important to the regional persistence of malaria parasites. Here, we identify putative malaria sources and sinks for pre-elimination Namibia using malaria parasite rate (PR) maps and call data records from mobile phones, using a steady-state analysis of a malaria transmission model to infer where infections most likely occurred. We also examined how the landscape of transmission and burden changed from the pre-elimination setting by comparing the location and extent of predicted pre-elimination transmission foci with modeled incidence for 2009. This comparison suggests that while transmission was spatially focal pre-elimination, the spatial distribution of cases changed as burden declined. The changing spatial distribution of burden could be due to importation, with cases focused around importation hotspots, or due to heterogeneous application of elimination effort. While this framework is an important step towards understanding progressive changes in malaria distribution and the role of subnational transmission dynamics in a policy-relevant way, future work should account for international parasite movement, utilize real time surveillance data, and relax the steady state assumption required by the presented model.
Prediction of Intention during Interaction with iCub with Probabilistic Movement Primitives

This paper describes our open-source software for predicting the intention of a user physically interacting with the humanoid robot iCub. Our goal is to allow the robot to infer the intention of the human partner during collaboration, by predicting the future intended trajectory: this capability is critical to design anticipatory behaviors that are crucial in human-robot collaborative scenarios, such as in co-manipulation, cooperative assembly or transportation. We propose an approach to endow the iCub with basic capabilities of intention recognition, based on Probabilistic Movement Primitives (ProMPs), a versatile method for representing, generalizing, and reproducing complex motor skills. The robot learns a set of motion primitives from several demonstrations, provided by the human via physical interaction. During training, we model the collaborative scenario using human demonstrations. During the reproduction of the collaborative task, we use the acquired knowledge to recognize the intention of the human partner. Using a few early observations of the state of the robot, we can not only infer the intention of the partner, but also complete the movement, even if the user breaks the physical interaction with the robot. We evaluate our approach in simulation and on the real iCub. In simulation, the iCub is driven by the user using the Geomagic Touch haptic device. In the real robot experiment, we directly interact with the iCub by grabbing and manually guiding the robot's arm. We realize two experiments on the real robot: one with simple reaching trajectories, and one inspired by collaborative object sorting. The software implementing our approach is open-source and available on the GitHub platform. Additionally, we provide tutorials and videos.
DECISION AUGMENTATION THEORY: TOWARD A MODEL OF ANOMALOUS MENTAL PHENOMENA

Decision augmentation theory (DAT) holds that humans integrate information obtained by anomalous cognition into the usual decision process. The result is that, to a statistical degree, such decisions are biased toward volitional outcomes. We introduce our model and show that the domain over which it is applicable is within a few standard deviations from chance. We contrast the theory's experimental consequences with those of models that treat anomalous effects as due to a force. We derive mathematical expressions for DAT and force-like models using two distributions, normal and binomial. DAT is testable both retrospectively and prospectively, and we provide statistical power curves to assist in the experimental design of such tests. We show that the experimental consequences of our theory are different from those of force-like models except for one special case.