Miracle-dz/UniFAR-FTUs huggingface dataset:
A FIRST-ORDER FRAMEWORK FOR MANAGING MODELS INENGINEERING

Approximation management framework (AMF) is a methodology for optimizing the use of lower-delity models in iterative procedures while attaining convergence to high-delity results. We discuss the performance of a rst-order SQP-based AMF. Models managed in AMF include variable resolution and variable physical delity simulations, and a number of response surface surrogates. Demonstration with several aerodynamic optimization problems is presented.
GluR5 and GluR6 Kainate Receptor Subunits Coexist in Hippocampal Neurons and Coassemble to Form Functional Receptors

We have performed nonradioactive double in situhybridization to study the expression of glutamic acid decarboxylase and GluR6 or GluR5 subunits in hippocampal slices. Our results indicate that although GluR6 is primarily expressed by pyramidal cells and dentate granule neurons and GluR5 is prominently expressed in nonpyramidal cells, there is a significant population of GABAergic interneurons that coexpress the two glutamate receptor subunits. To assess whether the two subunits could coassemble to form heteromeric receptors, we studied the electrophysiological responses when both subunits were coexpressed in HEK293 cells. Responses evoked by rapid application of either glutamate, (RS)-α-amino-3-hydroxy-5-tert-butyl-4-isoxazolepropionic acid (ATPA) the selective agonist of GluR5 receptors), and AMPA in cells cotransfected with GluR6(R) and GluR5(Q) presented a similar degree of outward rectification. This can only be attributed to the fact that all receptors have at least one GluR6(R) subunit in their structure, conferring outward rectification, and at least one GluR5(Q) subunit to confer sensitivity to ATPA and AMPA. More than 80% of the receptors expressed by a single cell were found to be GluR5/R6 heteromers, presenting different desensitization and gating properties to homomeric R6 receptors. These results lead us to believe that a population of interneurons in the hippocampus express receptors made up of both GluR5 and GluR6 subunits and provide evidence for a greater diversity of kainate receptors in the brain than previously thought, that may account for a higher functional complexity.
A rapid algorithm for curve denoising

Contour curves of shapes are important features for image analysis and understanding. A contour curve might be affected by various kinds of noise. In this paper a rapid curve denoising algorithm is proposed, which is equivalent to the existing Gaussian smoothing according to a convergence property of noise. A key problem of the rapid algorithm is to select a proper smoothing radius. We first sample a few of points on the noisy curve, with which the severity of noise is measured. Then a linear model is established to interpret the relationship between the noise severity and the smoothing radius. Finally, based on a series of numerical tests, the smoothing radius is evaluated. Experimental results show that the proposed algorithm has a comparable performance as the Gaussian; however, at much less computational cost.
Concerning the Difference Between a Conception and its Application in the Case of the Estonian WordNet

One source of Estonian WordNet have been corpora of Estonian. On the other hand, we get interested in word sense disambiguation, and about 100,000 words in corpora are manually disambiguated according to Estonian WordNet senses. The aim of this paper is to explain some theoretical problems that ido not work well in practicei. These include the differentiation of word senses, metaphors, and conceptual word combinations.
QUICK RESPONSE CODE

Quick Response Code Indonesian Standard (QRIS) is the most efficient instant payment method which is a collaboration product between Bank Indonesia and the Indonesian Payment System Association (ASPI). QRIS as the latest server-based non-cash payment method that is integrated with digital wallets has been used in retails or minimarkets such as Alfamart. The use of server-based electronic money with digital wallets is very popular today. The purpose of this study is to reveal whether the use of QRIS can have an impact on Alfamart Talaga Wetan's sales profit and how Alfamart's customer satisfaction after using QRIS. The research method used is a naturalistic qualitative method to reveal the actual state of social phenomena that are tentative (temporary). Data collection techniques were carried out through observation, interviews and documentation methods. The result of this study is that QRIS has an impact on Alfamart Talaga Wetan's sales profit as seen from the BAP reports in May, June and July 2022 which had a significant impact. The use of QRIS also has an impact on Alfamart's customer satisfaction, seen from the answers of 8 interviewees who all agreed that they were satisfied because QRIS can help speed transactions and minimize queues.
Risk Measurement of Securities and Empirical Study Based on Reference Point Transfer

Because agents are not properly described by current measurement of risk, After analyzing and summarizing the definition and measurement of risk, according to prospect theory, this paper find out reasons are description of risk’s two traits doesn’t accord with human cognitive psychology and same measurement is used in the different frame of winning state and lost state because reference point is chose on improper level. According to aforementioned problems and prospect theory, reference point is transferred from the level of winning state and lost state to the level of price ascending and descending, then a corresponding model is established, finally advantages of model are explained by an empirical example.
Complex Regulation by Apetala2 Domain-Containing Transcription Factors Revealed through Analysis of the Stress-Responsive TdCor410b Promoter from Durum Wheat

Expression of the wheat dehydrin gene Cor410b is induced several fold above its non-stressed levels upon exposure to stresses such as cold, drought and wounding. Deletion analysis of the TdCor410b promoter revealed a single functional C-repeat (CRT) element. Seven transcription factors (TFs) were shown to bind to this CRT element using yeast one-hybrid screens of wheat and barley cDNA libraries, of which only one belonged to the DREB class of TFs. The remaining six encoded ethylene response factors (ERFs) belong to three separate subfamilies. Analysis of binding selectivity of these TFs indicated that all seven could bind to the CRT element (GCCGAC), and that three of the six ERFs could bind both to the CRT element and the ethylene-responsive GCC-box (GCCGCC). The TaERF4 subfamily members specifically bound the CRT element, and did not bind either the GCC-box or DRE element (ACCGAC). Molecular modeling and site-directed mutagenesis identified a single residue Pro42 in the Apetala2 (AP2) domain of TaERF4-like proteins that is conserved in monocotyledonous plants and is responsible for the recognition selectivity of this subfamily. We suggest that both DREB and ERF proteins regulate expression of the Cor410b gene through a single, critical CRT element. Members of the TaERF4 subfamily are specific, positive regulators of Cor410b gene expression.
Bile acid secretion and direct targeting of mdr1-green fluorescent protein from Golgi to the canalicular membrane in polarized WIF-B cells.

The bile canalicular membrane contains several ATP-dependent transporters that are involved in biliary secretion. Canalicular transporters are synthesized in ER, modified in Golgi and transported to the apical plasma membrane. However, the route and regulation of intracellular trafficking of ATP-dependent transporters have not been elucidated. In the present study, we generated a translational fusion of mdr1 and green fluorescent protein and investigated bile acid secretion and intracellular trafficking of mdr1 in WIF-B cells, a polarized liver derived cell line. Similar to hepatocytes, WIF-B cells secrete bile acids and organic cations (i.e. rhodamine-123) into the bile canaliculi. Canalicular secretion of fluorescein isothiocyanate-glycocholate was stimulated by taurocholate and a decapeptide activator of phosphoinositide 3-kinase and was decreased by wortmannin. WIF-B9 cells were transiently and stably transfected with a mdr1-GFP construct. Fluorescence was observed in the canalicular membrane, pericanalicular punctate structures and Golgi region. Time lapse microscopy revealed that mdr1-GFP is transferred from Golgi as tubular vesicular structures the majority of which traveled directly to the canalicular membrane. Recycling between the canalicular membrane and subapical region was also observed. At no time was mdr1-GFP detected in the basolateral plasma membrane. At 15 degrees C, mdr1-GFP accumulated in Golgi; after a shift to 37 degrees C, fluorescence moved directly to the canalicular membrane. This process was enhanced by taurocholate and blocked by wortmannin. In these studies as well, no mdr1-GFP fluorescence was observed at any time in basolateral membranes or other intracellular organelles. In conclusion, in WIF-B cells, there is a direct route from Golgi to the canalicular membrane for trafficking of mdr1, a bile canalicular ATP-dependent transporter of organic cations. As in normal hepatocytes, phosphoinositide 3-kinase regulates bile acid secretion and intracellular trafficking of mdr1 in WIF-B cells. WIF-B cells stably transfected with mdr1-GFP provide an important model in which to study trafficking and regulation of canalicular transporters. Movies available on-line: http://www.healthsci. tufts.edu/LABS/IMArias++ + /Sai_F9. html
Multiple Functional Risk Variants in a SMAD7 Enhancer Implicate a Colorectal Cancer Risk Haplotype

Genome-wide association studies (GWAS) of colorectal cancer (CRC) have led to the identification of a number of common variants associated with modest risk. Several risk variants map within the vicinity of TGFβ/BMP signaling pathway genes, including rs4939827 within an intron of SMAD7 at 18q21.1. A previous study implicated a novel SNP (novel 1 or rs58920878) as a functional variant within an enhancer element in SMAD7 intron 4. In this study, we show that four SNPs including novel 1 (rs6507874, rs6507875, rs8085824, and rs58920878) in linkage disequilibrium (LD) with the index SNP rs4939827 demonstrate allele-specific enhancer effects in a large, multi-component enhancer of SMAD7. All four SNPs demonstrate allele-specific protein binding to nuclear extracts of CRC cell lines. Furthermore, some of the risk-associated alleles correlate with increased expression of SMAD7 in normal colon tissues. Finally, we show that the enhancer is responsive to BMP4 stimulation. Taken together, we propose that the associated CRC risk at 18q21.1 is due to four functional variants that regulate SMAD7 expression and potentially perturb a BMP negative feedback loop in TGFβ/BMP signaling pathways.
Optimized bus scheduling based on improved multi ojective genetic algorithm

— It is close to difficult to perform the transport planning of urban transport lines which perform the operational cost and enhance the nature of transport. the fundamental reason for this paper to minimize holding up time of traveler on that particular course and expand the entire benefit of MSRTC. the one needs to dole out transport to travel a set of excursion containing time table while minimizing number of destinations that may clash with every other. Actually we are considering all methodologies and targets in the weighted manner to discover single goals and the uses single target advancement approach to explain it.
Immunization against Lamb Haemonchosis with a Recombinant Somatic Antigen of Haemonchus contortus (rHcp26/23)

Haemonchosis, caused by the abomasal nematode Haemonchus contortus, is a common parasitic disease of sheep. Our previous results showed that a soluble fraction from adult stages of the nematode (p26/23) induced partial protection against challenge. Recombinant DNA technology was applied to obtain a synthetic protein (rHcp26/23). Immunological assays (ELISA, Western blotting, and immunolocalization), using sera from lambs immunized with p26/23, confirmed the identity of the recombinant protein and demonstrated that the synthetic protein is equivalent to the purified protein employed in the previous immunoprophylaxis studies. Vaccination of lambs with 300 μg of rHcp26/23 and Freund's adjuvant elicited a notable specific antibody response. Immunization did not induce any significant protection after challenge with 16000 infective larvae of H. contortus, and comparable values for parasite faecal egg output, packed cell volume, and abomasal parasite burdens were found in vaccinated and control animals.
1 2 Ju l 2 01 2 Exchange interactions and T c in rhenium doped silicon : DFT , DFT + U and Monte Carlo calculations

Interactions between rhenium impurities in silicon are investigated by means of the density functional theory (DFT) and the DFT+U scheme. All couplings between impurities are ferromagnetic except the Re-Re dimers which in the DFT method are nonmagnetic, due to formation of the chemical bond supported by substantial relaxation of the geometry. The critical temperature is calculated by means of classical Monte Carlo (MC) simulations with the Heisenberg hamiltonian. The uniform ferromagnetic phase is obtained with the DFT exchange interactions at room temperature for the impurities concentration of 7 %. With the DFT+U exchange interactions, the ferromagnetic clusters form above room temperature in MC samples containing only 3 % Re.
Towards a framework definition for learning process engineering supported by an adaptive learning system

The work presented in this paper is related to the area of learning process engineering (LPE) which focuses on learning process construction supported by an adaptive learning system. This area has emerged in response to an increasing awareness that existing learning processes are not well suited to the needs of the learners, the teachers, the tutors, the system administrators and the system designers. We propose a faceted framework to understand and classify issues in learning process construction. This latter identifies four different and complementary viewpoints. Each view allows us to capture a particular aspect of the learning process. In order to study, understand and classify a particular view of LPE in its diversity, we associate a set of facets with each view. While a facet allows an in-depth description of one specific aspect of LPE, the views show the variety and diversity of these aspects.
Investigation of Local-Alignment Search for Large Biological Sequences indexed using Suffix

One of the most important applications of a string database is storing large gene sequences. Typically the database should support queries like exact matching and pattern matching. The main hindrance to any direct approach for solving this problem is the large amount of unstructured data (of the order of GB) involved. A promising index structure for this problem is the suffix tree. In 2001, Hunt et al, put forth the idea of adapting this structure to the disk. In 2003, Meek et al proposed OASIS – an algorithm that uses this suffix tree to perform a local alignment search against a gene sequence. In this paper we present results of experiments conducted on the implementations of the disk-based suffix tree and OASIS. The main purpose was to see how both the algorithms scale with increasing data and query sizes, and in general verify the results presented in the original papers. We compared the disk-based suffix tree with the sequential scan and found that it gives better performance for a good range of query lengths. For OASIS, we observed that the performance deteriorates significantly with increasing query size. The usefulness of the algorithm is limited beyond queries with lengths of 10-12 characters.
A tree-structured DFT filter bank based spectrum sensor for estimation of radio channel edge frequencies in military wideband receivers

Accurate Spectrum sensing is a vital task in military wideband receivers. The discrete Fourier transform filter bank (DFTFB) used in conventional energy detectors fails to detect the exact locations and edges of occupied frequency bands (channels). In this paper, an energy detector based on tree-structured DFTFB (TDFTFB) is proposed for detecting the edges of channels. Simulation results are presented to show the trade-off between accurate edge detection and the number of filter bank stages required. Simulation results show that the proposed method detects the edges of channels with an error less than 2% using a 2-stage, 8 point TDFTFB while the conventional DFTFBs cannot detect the edges of the channels. The receiver operating characteristics (ROC) plot for the proposed method shows better performance than the conventional DFTFBs.
The three governances in social innovation

This paper explores the relationship between governance and social innovation in the area of organizations. In order to understand that relationship, we offer a model that links the absorptive capacity of knowledge [Cohen and Levinthal 1990. “Absorptive Capacity: A new Perspective on Learning and Innovation. ” Administrative Science Quarterly 35 (1): 128–152] with open innovation [Chesbrough and Di Minin 2014. “Open Social Innovation. ” In New Frontiers in Open Innovation, edited by H. Chesbrough, W. Vanhaverbeke, and J. West, 169–187. Oxford: Oxford University Press]. On the basis of the pilot study Regional Social Innovation Index carried out in the Basque Country (Spain), we empirically explore three types of governance (social, inter-organizational, and sustainable) in social innovation projects propelled by four types of key agents at a regional level: profit and non-profit organizations, universities, and technology centers. The proposed governance Index in Social Innovation contributes to discussions about governance and social innovation at a micro level and, and to the debate about the production of indicators in social innovation.
Enhancement of Color Microscopic Images Using Toboggan Method

The images taken from an optical electronic microscope often contain data corrupted by noise, and the subject under study is normally blur due to improper focusing during image acquisition. Thus, in this paper, we propose the use of toboggan contrast enhancement method to solve this problem. First, the noise level in the image is reduced by using Gaussian filter. Gaussian filtering results more blur edges. Thus, toboggan contrast enhancement is applied to restore the edges. Experimental result, from an image of algae taken by an optical microscope, shows that toboggan contrast enhancement successfully sharpen the image.
Eosinophilic activation in cystic fibrosis.

BACKGROUND--The neutrophil is a potent contributor to pulmonary destruction in cystic fibrosis. Since eosinophils also possess destructive potential the involvement of eosinophils in cystic fibrosis has been investigated. METHODS--Eosinophil numbers and levels of eosinophil cationic protein (ECP), a marker of eosinophil activation, were determined in the serum of 42 patients with cystic fibrosis and in the sputum of 10 of them. To determine neutrophil activation levels of myeloperoxidase (MPO) were also measured. RESULTS--In cystic fibrosis increased serum levels of ECP were detected compared with healthy non-atopic subjects. Serum ECP levels were not related to the peripheral blood eosinophil count. A strong correlation with ECP concentrations in sputum indicated that the level of ECP in serum was representative of its pulmonary level. Levels of MPO were also increased in cystic fibrosis. A strong correlation was found between MPO and pulmonary function. In addition, ECP was related to arterial oxygen and carbon dioxide tensions. Antibiotic treatment reduced neutrophil activation without effect on ECP levels. CONCLUSIONS--Until now Pseudomonas aeruginosa and neutrophils were held to be primarily responsible for progressive tissue damage in cystic fibrosis. The results of this study suggest that eosinophils might also participate in such pulmonary destruction.
Effects of daminozide on somatic embryogenesis from immature and mature embryos of wheat.

The influence of daminozide, an inhibitor of gibberellins biosynthesis, on the somatic embryogenesis in immature and mature embryo derived from tissue cultures of wheat was investigated. Low concentrations of daminozide (0.064-0.127 mM) positively affected the somatic embryogenic capacity of immature embryos (cv. ‘Andros’) cultured on the medium supplemented with either 2,4-dichlorophenoxyacetic acid (2,4-D) or dicamba or para chlorophenoxyacetic acid ( p-CPA). The higher concentration of daminozide (0.51-1.02 mM) reduced the regeneration of shoots. The modification of exogenous/endogenous ratio of gibberellins by application of exogenous GA 3 did not remove the effect of daminozide. On the contrary, its combination with GA 3 inhibited the somatic embryogenesis and resulted in the supression of the development of somatic embryos. The supplement of 0.127 mM daminozide to 2,4-D containing medium increased the embryogenic competence of immature embryos of eleven Russian spring and winter varieties. For ten varieties the number of shoots produced per callus did not differ statistically from the control medium; one variety showed the increase of shoot number. In contrast with immature wheat embryos, mature ones (cv. Tajoznaja) did not response to daminozide supplementation either of the inductive or the different- tiative media. The present observations provide a method to increase the embryogenesis efficiency for wheat commercial varieties which immature embryos display low embryogenic potential. Abbereviations: 2,4-D_ 2,4-dichlorophenoxyacetic acid; p-CPA_ para chlorophenoxyacetic acid; GA 3_ gibberellic acid; GAs _ gibberellins; ABA_ abscisic acid.
Design of a CMOS 12 GHz Rotary Travelling Wave Oscillator with switched capacitor tuning

This paper presents the design methodology, simulation and measurement results of a CMOS 12GHz Rotary Travelling Wave Voltage Controlled Oscillator. The different simulations (electrical using SPICE and electromagnetical using HFSS) are presented. These results are compared to a theoretical approach and measurements. The oscillator has been fabricated in a 0. 13µm RF-CMOS technology. The phase noise at a 1MHz offset from the carrier is −105dBc/Hz and the tuning range is 1.2GHz for a global consumption of 25mA.
Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T cell receptor alpha/beta lineage: T cell receptor delta gene deletion mechanism affects multiple genes

Site-specific deletions in the tal-1 gene are reported to occur in 12- 26% of T cell acute lymphoblastic leukemias (T-ALL). So far two main types of tal-1 deletions have been described. Upon analysis of 134 T- ALL we have found two new types of tal-1 deletions. These four types of deletions juxtapose the 5' part of the tal-1 gene to the sil gene promoter, thereby deleting all coding sil exons but leaving the coding tal-1 exons undamaged. The recombination signal sequences (RSS) and fusion regions of the tal-1 deletion breakpoints strongly resemble the RSS and junctional regions of immunoglobulin/T cell receptor (TCR) gene rearrangements, which implies that they are probably caused by the same V(D)J recombinase complex. Analysis of the 134 T-ALL suggested that the occurrence of tal-1 deletions is associated with the CD3 phenotype, because no tal-1 deletions were found in 25 TCR-gamma/delta + T-ALL, whereas 8 of the 69 CD3- T-ALL and 11 of the 40 TCR-alpha/beta + T-ALL contained such a deletion. Careful examination of all TCR genes revealed that tal-1 deletions exclusively occurred in CD3- or CD3+ T- ALL of the alpha/beta lineage with a frequency of 18% in T-ALL with one deleted TCR-delta allele, and a frequency of 34% in T-ALL with TCR- delta gene deletions on both alleles. Therefore, we conclude that alpha/beta lineage commitment of the T-ALL and especially the extent of TCR-delta gene deletions determines the chance of a tal-1 deletion. This suggests that tal-1 deletions are mediated via the same deletion mechanism as TCR-delta gene deletions.