Miracle-dz/UniFAR-FTUs huggingface dataset:
Poverty Trajectories Experienced by Persons with Mental Illness

ABSTRACT The present study aimed to better understand the relationship between mental illness and poverty by comparing three groups of individuals with mental illness in Canada: those who see their financial status as improving, worsening, or staying the same. This study used a focused ethnography approach to collect qualitative data from 34 focus group participants. Participants highlighted several facilitators and barriers to financial improvement and often described their financial situation as a cycle that was difficult to escape. Results are discussed in terms of policy implications to facilitate both a movement toward mental health and away from poverty.
Blind Image Deconvolution by Automatic Gradient Activation

Blind image deconvolution is an ill-posed inverse problem which is often addressed through the application of appropriate prior. Although some priors are informative in general, many images do not strictly conform to this, leading to degraded performance in the kernel estimation. More critically, real images may be contaminated by nonuniform noise such as saturation and outliers. Methods for removing specific image areas based on some priors have been proposed, but they operate either manually or by defining fixed criteria. We show here that a subset of the image gradients are adequate to estimate the blur kernel robustly, no matter the gradient image is sparse or not. We thus introduce a gradient activation method to automatically select a subset of gradients of the latent image in a cutting-plane-based optimization scheme for kernel estimation. No extra assumption is used in our model, which greatly improves the accuracy and flexibility. More importantly, the proposed method affords great convenience for handling noise and outliers. Experiments on both synthetic data and real-world images demonstrate the effectiveness and robustness of the proposed method in comparison with the state-of-the-art methods.
Dynamic Control of Location-Specific Information in Tactile Cutaneous Reflexes from the Foot during Human Walking

The purpose of the present study was to determine whether tactile cutaneous reflexes from the skin of the foot contain location-specific information during human walking. Muscular responses to non-nociceptive electrical stimulation of the sural, posterior tibial, and superficial peroneal nerves, each supplying a different skin area of the foot, were studied in both legs during walking on a treadmill. For all three nerves the major responses in all muscles were observed at a similar latency of ∼80–85 msec. In the ipsilateral leg these reflex responses and their phase-dependent modulation were highly nerve-specific. During most of the stance phase, for example, the peroneal and tibial nerves generally evoked small responses in the biceps femoris muscle. In contrast, during late swing large facilitations generally occurred for the peroneal nerve, whereas suppressions were observed for the tibial nerve. In the contralateral leg the reflex responses for the three nerves were less distinct, although some nerve specificity was observed for individual subjects. It is concluded that non-nociceptive stimulation of the sural, posterior tibial, and superficial peroneal nerves each evokes distinct reflex responses, indicating the presence of location-specific information from the skin of the foot in cutaneous reflexes during human walking. It will be argued that differentially controlled reflex pathways can account for the differences in the phase-dependent reflex modulation patterns of the three nerves, which points to the dynamic control of this information during the course of a step cycle.
Distributional Properties of Inhibited Random Positions of Mobile Radio Terminals

Randomly generated points representing the deployment of radio terminals (nodes) in an area R can be unrealistical ly close together (clustered) and the resulting connectivity measure for the wireless network (such as average number of neighbors per node) can have a relatively large variance. When a minimum internode distance is imposed according to an "inhibition" random process, the simulated node positions are more regularly spaced and the connectivity measure has a smaller vari- ance. In this paper, analytical methods are presented that characterize the spatial distribution ("area cover- age") of the nodes under random and inhibited point gen- eration processes, and expressions are found for the mean and variance of the number of neighbors.
Epoxysuccinyl Peptide-Derived Cathepsin B Inhibitors: Modulating Membrane Permeability by Conjugation with the C-Terminal Heptapeptide Segment of Penetratin

Abstract Besides its physiological role in lysosomal protein breakdown, extralysosomal cathepsin B has recently been implicated in apoptotic cell death. Highly specific irreversible cathepsin B inhibitors that are readily cellpermeant should be useful tools to elucidate the effects of cathepsin B in the cytosol. We have covalently functionalised the poorly cellpermeant epoxysuccinyl based cathepsin B inhibitor [RGlyGlyLeu(2S, 3S)tEpsLeuProOH; R=OMe] with the Cterminal heptapeptide segment of penetratin (R=AhxArg ArgNleLysTrpLysLysNH2). The high inhibitory potency and selectivity for cathepsin B versus cathepsin L of the parent compound was not affected by the conjugation with the penetratin heptapeptide. The conjugate was shown to efficiently penetrate into MCF-7 cells as an active inhibitor, thereby circumventing an intracellular activation step that is required by other inhibitors, such as the prodruglike epoxysuccinyl peptides E64d and CA074Me.
Test Case Generation and Reusing Test Cases for GUI Designed with HTML

Graphical User Interface (GUI) is pervasive to the extent that half of the code of the software systems written today is to produce the required GUIs. Test case generation for GUI based software systems is complex as it is necessary to include all possible sequences of events that may be exercised by the widget or end-user. The major issue with GUI based systems is that even a single change in the GUI may make the entire suite of existing test cases unusable. Hence a solution to analyze the existing test cases (i.e. the test cases that were already generated before modification of GUI) and identify the test cases that have become unusable and that are reusable in the context of the modified GUI is provided here. Test cases that are reusable are retained and the test cases that have become unusable are subjected to transformations. These transformations make the unusable test cases reusable through the construction of Event Flow Graph (EFG) generated and parsing EFG using Depth First Search (DFS) to identify reusable and unusable test cases.
Walking pace affected by interactive sounds simulating stepping on different terrains

This article investigates whether auditory feedback affects natural locomotion patterns. Individuals were provided with footstep sounds simulating different surface materials. The sounds were interactively generated using shoes with pressure sensors. Results showed that subjects' walking speed changed as a function of the type of simulated ground material. This effect may arise due to the presence of conflicting information between the auditory and foot-haptic modality, or because of an adjustment of locomotion to the physical properties evoked by the sounds simulating the ground materials. The results reported in this study suggest that auditory feedback may be more important in the regulation of walking in natural environments than has been acknowledged. Furthermore, auditory feedback could be used to develop novel approaches to the design of therapeutic and rehabilitation procedures for locomotion.
An extensive photometric study of the Blazhko RR Lyrae star DM Cyg

DM Cyg, a fundamental mode RRab star, was observed in the 2007 and 2008 seasons in the framework of the Konkoly Blazhko Survey. Very small amplitude light-curve modulation was detected with 10.57 d modulation period. The maximum brightness and phase variations do not exceed 0.07 mag and 7 min, respectively. In spite of the very small amplitude of the modulation, beside the frequency triplets characterizing the Fourier spectrum of the light curve, two quintuplet components were also identified. The accuracy and the good phase coverage of our observations made it possible to analyse the light curves at different phases of the modulation separately. Utilizing the inverse photometric Baade-Wesselink method, we could detect very small systematic changes in the global mean physical parameters of DM Cyg during its Blazhko cycle. The detected changes are similar to what we have already found for a large modulation amplitude Blazhko variable, MW Lyrae. The amplitudes of the detected changes in the physical parameters of DM Cyg are only about 10 per cent of those that have been found in MW Lyr. This is in accordance with its small modulation amplitude being about one-tenth of the modulation amplitude of MW Lyr. The pulsation period of DM Cyg has been increasing by a rate of β = 0.091 d Myr ―1 during the hundred-year time base of the observations. Konkoly archive photographic observations indicate that when the pulsation period of the variable was shorter by Δp puls = 5 x 10 ―6 d the modulation period was longer by Δp mod = 0.066 d than today.
Effective removal of protein-bound uraemic solutes by different convective strategies: a prospective trial.

BACKGROUND Although different on-line convective removal strategies are available, there are no studies comparing the efficiency of solute removal for the three main options [post-dilution haemodiafiltration (post-HDF), pre-dilution haemodiafiltration (pre-HDF) and pre-dilution haemofiltration (pre-HF)] in parallel. METHODS In this study, we compared post-HDF (Polyflux 170), pre-HDF (Polyflux 170) and pre-HF (Polyflux 210) in 14 patients. Parallelism of the evaluation protocols consisted in applying the same blood flow, dialysis time and effective convection (22.9 +/- 1.7 versus 22.2 +/- 2.0 L, P = NS) in pre-HDF versus post-HDF, and the same blood flow and dialysis time while comparing pre-HDF and pre-HF (1:1 dilution). With pre-HF, ultrafiltration was maximized and resulted in an effective convective volume of 28.5 L. We studied water-soluble compounds (urea, creatinine, uric acid), protein-bound compounds (hippuric acid, indole acetic acid, indoxylsulfate and p-cresylsulfate) and beta(2)-microglobulin (beta(2)M). RESULTS Post-HDF was superior to pre-HDF for water-soluble compounds and beta(2)M, whereas there was no difference for protein-bound compounds. Pre-HDF was superior to pre-HF for water-soluble compounds and protein-bound compounds. In contrast, removal of beta(2)M for pre-HF was higher than for pre-HDF, but it did not differ from that obtained with post-HDF. CONCLUSIONS It is concluded that post-dilution is superior to pre-dilution HDF under conditions of similar convective volume, and that HDF is superior to HF in pre-dilution, with the exception of removal of beta(2)M. Overall, post-HDF is the most efficient convective strategy among those tested.
Assessment of Coupling between Trans-Abdominally Acquired Fetal ECG and Uterine Activity by Bivariate Phase-Rectified Signal Averaging Analysis

Couplings between uterine contractions (UC) and fetal heart rate (fHR) provide important information on fetal condition during labor. At present, couplings between UC and fHR are assessed by visual analysis and interpretation of cardiotocography. The application of computerized approaches is restricted due to the non-stationarity of the signal, missing data and noise, typical for fHR. Herein, we propose a novel approach to assess couplings between UC and fHR, based on a signal-processing algorithm termed bivariate phase-rectified signal averaging (BPRSA). Methods Electrohysterogram (EHG) and fetal electrocardiogram (fECG) were recorded non-invasively by a trans-abdominal device in 73 women at term with uneventful singleton pregnancy during the first stage of labor. Coupling between UC and fHR was analyzed by BPRSA and by conventional cross power spectral density analysis (CPSD). For both methods, degree of coupling was assessed by the maximum coefficient of coherence (CPRSA and CRAW, respectively) in the UC frequency domain. Coherence values greater than 0.50 were consider significant. CPRSA and CRAW were compared by Wilcoxon test. Results At visual inspection BPRSA analysis identified coupled periodicities in 86.3% (63/73) of the cases. 11/73 (15%) cases were excluded from further analysis because no 30 minutes of fECG recording without signal loss was available for spectral analysis. Significant coupling was found in 90.3% (56/62) of the cases analyzed by BPRSA, and in 24.2% (15/62) of the cases analyzed by CPSD, respectively. The difference between median value of CPRSA and CRAW was highly significant (0.79 [IQR 0.69–0.90] and 0.29 [IQR 0.17–0.47], respectively; p<0.0001). Conclusion BPRSA is a novel computer-based approach that can be reliably applied to trans-abdominally acquired EHG-fECG. It allows the assessment of correlations between UC and fHR patterns in the majority of labors, overcoming the limitations of non-stationarity and artifacts. Compared to standard techniques of cross-correlations, such as CPSD, BPRSA is significantly superior.
Coronary evaginations are associated with positive vessel remodelling and are nearly absent following implantation of newer-generation drug-eluting stents: an optical coherence tomography and intravascular ultrasound study.

OBJECTIVES The purpose of this study was to assess the occurrence, predictors, and mechanisms of optical coherence tomography (OCT)-detected coronary evaginations following drug-eluting stent (DES) implantation. BACKGROUND Angiographic ectasias and aneurysms in stented segments have been associated with a risk of late stent thrombosis. Using OCT, some stented segments show coronary evaginations reminiscent of ectasias. METHODS Evaginations were defined as outward bulges in the luminal contour between struts. They were considered major evaginations (MEs) when extending ≥3 mm along the vessel length, with a depth ≥10% of the stent diameter. A total of 228 patients who had sirolimus (SES)-, paclitaxel-, biolimus-, everolimus (EES)-, or zotarolimus (ZES)-eluting stents implanted in 254 lesions, were analysed after 1, 2, or 5 years; and serial assessment using OCT and intravascular ultrasound (IVUS) was performed post-intervention and after 1 year in 42 patients. RESULTS Major evaginations occurred frequently at all time points in SES (∼26%) and were rarely seen in EES (3%) and ZES (2%, P = 0.003). Sirolimus-eluting stent implantation was the strongest independent predictor of ME [adjusted OR (95% CI) 9.1 (1.1-77.4), P = 0.008]. Malapposed and uncovered struts were more common in lesions with vs. without ME (77 vs. 25%, P < 0.001 and 95 vs. 20%, P < 0.001, respectively) as was thrombus [49 vs. 14%, OR 7.3 (95% CI: 1.7-31.2), P = 0.007]. Post-intervention intra-stent dissection and protrusion of the vessel wall into the lumen were associated with an increased risk of evagination at follow-up [OR (95% CI): 2.9 (1.8-4.9), P < 0.001 and 3.3 (1.6-6.9), P = 0.001, respectively]. In paired IVUS analyses, lesions with ME showed a larger increase in the external elastic membrane area (20% area change) compared with lesions without ME (5% area change, P < 0.001). CONCLUSION Optical coherence tomography-detected MEs are a specific morphological footprint of early-generation SES and are nearly absent in newer-generation ZES and EES. Evaginations appear to be related to vessel injury at baseline; are associated with positive vessel remodelling; and correlate with uncoverage, malapposition, and thrombus at follow-up.
A Generalization of Dedekind Criterion

Let K = ℚ(θ) be an algebraic number field with θ in the ring A K of algebraic integers of K and f(x) be the minimal polynomial of θ over the field ℚ of rational numbers. For a rational prime p, let (x) = (x) e 1 … (x) e r be the factorization of the polynomial (x) obtained by replacing each coefficient of f(x) modulo p into product of powers of distinct irreducible polynomials over ℤ/pℤ with g i (x) monic. In 1878, Dedekind proved that if p does not divide [A K :ℤ[θ]], then , where ℘1,…, ℘ r are distinct prime ideals of A K , ℘ i = pA K + g i (θ)A K with residual degree f(℘ i /p) = deg (x). He also gave a criterion which says that p does not divide [A K :ℤ[θ]] if and only if for each i, we have either e i = 1 or (x) does not divide where . The analog of the above result regarding the factorization in A K′ of any prime ideal 𝔭 of A K is in fact known for relative extensions K′/K of algebraic number fields with the condition “p ≠ | [A K :ℤ[θ]]” replaced by the assumption “every element of A K′ is congruent modulo 𝔭 to an element of A K [θ](†)”. In this article, our aim is to give a criterion like the one given by Dedekind which provides a necessary and sufficient condition for assumption (†) to be satisfied.
An overview of radio frequency technologies and their influence on the power efficiency of wireless communication systems

This article presents an overview of the RF technologies and their influence on the power efficiency of wireless communication systems. It analyzes the different RF technologies by classifying the RF technologies in three main groups: environment, architecture and circuit level groups. The environment group comprises the RF technologies with direct relationship to the system link budget. The second group defines the technologies which are sensitive to the system architecture as envelope tracking, envelope elimination and restoration, digital pre-distortion and RF interference cancellation. Finally, circuit design techniques with local impact on the power consumption as power amplifier topologies, intermodulation reduction techniques and dynamic antenna matching are presented.
EatA, an Immunogenic Protective Antigen of Enterotoxigenic Escherichia coli, Degrades Intestinal Mucin

ABSTRACT Enterotoxigenic Escherichia coli (ETEC) is a major cause of morbidity and mortality due to infectious diarrhea in developing countries for which there is presently no effective vaccine. A central challenge in ETEC vaccinology has been the identification of conserved surface antigens to formulate a broadly protective vaccine. Here, we demonstrate that EatA, an immunogenic secreted serine protease of ETEC, contributes to virulence by degrading MUC2, the major protein present in the small intestinal mucous layer, and that removal of this barrier in vitro accelerates toxin access to the enterocyte surface. In addition, we demonstrate that vaccination with the recombinant secreted passenger domain of EatA (rEatAp) elicits high titers of antibody and is protective against intestinal infection with ETEC. These findings may have significant implications for development of both subunit and live-attenuated vaccines against ETEC and other enteric pathogens, including Shigella flexneri, that express similar proteins.
Can milk cell or skim milk miRNAs be used as biomarkers for early pregnancy detection in cattle?

The most critical phase of pregnancy is the first three weeks following insemination. During this period about 50% of high yielding lactating cows suffer embryonic loss prior to implantation, which poses a high economic burden on dairy farmers. Early diagnosis of pregnancy in cattle is therefore essential for monitoring breeding outcome and efficient production intervals. Regulated microRNAs (miRNAs) that reach easily accessible body fluids via a ‘liquid biopsy’ could be a new class of pregnancy predicting biomarkers. As milk is obtained regularly twice daily and non-invasively from the animal, it represents an ideal sample material. Our aim was to establish a pregnancy test system based on the discovery of small RNA biomarkers derived from the bovine milk cellular fraction and skim milk of cows. Milk samples were taken on days 4, 12 and 18 of cyclic cows and after artificial insemination, respectively, of the same animals (n = 6). miRNAs were analysed using small RNA sequencing (small RNA Seq). The miRNA profiles of milk cells and skim milk displayed similar profiles despite the presence of immune cell related miRNAs in milk cells. Trends in regulation of miRNAs between the oestrous cycle and pregnancy were found in miR-cluster 25~106b and its paralog cluster 17~92, miR-125 family, miR-200 family, miR-29 family, miR-15a, miR-21, miR-26b, miR-100, miR-140, 193a-5p, miR-221, miR-223, miR-320a, miR-652, miR-2898 and let-7i. A separation of cyclic and pregnant animals was achieved in a principal component analysis. Bta-miRs-29b, -221, -125b and -200b were successfully technically validated using quantitative real-time PCR, however biological validation failed. Therefore we cannot recommend the diagnostic use of these miRNAs in milk as biomarkers for detection of bovine pregnancy for now.
Characterization of Static and Dynamic Left Ventricular Diastolic Function in Patients With Heart Failure With a Preserved Ejection Fraction

Background—Congestive heart failure in the setting of a preserved left ventricular (LV) ejection fraction is increasing in prevalence among the senior population. The underlying pathophysiologic abnormalities in ventricular function and structure remain unclear for this disorder. We hypothesized that patients with heart failure with preserved ejection fraction (HFPEF) would have marked abnormalities in LV diastolic function with increased static diastolic stiffness and slowed myocardial relaxation compared with age-matched healthy controls. Methods and Results—Eleven highly screened patients (4 men, 7 women) aged 73±7 years with HFPEF were recruited to participate in this study. Thirteen sedentary healthy controls (7 men, 6 women) aged 70±4 years also were recruited. All subjects underwent pulmonary artery catheterization with measurement of cardiac output, end-diastolic volumes, and pulmonary capillary wedge pressures at baseline; cardiac unloading (lower-body negative pressure or upright tilt); and cardiac loading (rapid saline infusion). The data were used to define the Frank-Starling and LV end-diastolic pressure-volume relationships. Doppler echocardiographic data (tissue Doppler velocities, isovolumic relaxation time, propagation velocity of early mitral inflow , E/A-wave ratio) were obtained at each level of cardiac preload. Compared with healthy controls, patients with HFPEF had similar LV contractile function and static LV compliance but reduced LV chamber distensibility with elevated filling pressures and slower myocardial relaxation as assessed by tissue Doppler imaging. Conclusions—In this small, highly screened patient population with hemodynamically confirmed HFPEF, increased end-diastolic static ventricular stiffness relative to age-matched controls was not a universal finding. Nevertheless, patients with HFPEF, even when well compensated, had elevated filling pressures, reduced distensibility, and increased diastolic wall stress compared with controls. In contrast, LV relaxation as assessed by tissue Doppler variables appeared consistently impaired in patients with HFPEF.