Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Planting Patterns on Soil Aggregates
and Enzyme Activities in Rocky Desertification
Areas of Karst Plateau Mountains

Soil aggregate characteristics and enzyme activities are key to the sustainable development of soil quality management. However, there are presently few studies on soil aggregate nutrients, enzyme activities, and their driving factors in areas with karst rocky desertification. As such, this study investigated the effects of planting patterns on soil aggregate nutrients and soil enzyme activities under six typical planting patterns ( walnut, Rosa roxburghii Tratt, ryegrass, walnut-Rosa roxburghii Tratt, Rosa roxburghii Tratt-ryegrass and walnut-ryegrass ) in the karst rocky desertification area of plateau mountains. The results indicated that: (1) there were significant differences in soil aggregate nutrients and soil enzyme activities among the different plots, when compared to traditional farmland, the increase in the aggregate nutrient content and soil enzyme activities was most noticeable in walnut-Rosa roxburghii Tratt, Rosa roxburghii Tratt-ryegrass , and walnut-ryegrass , and the nutrients gradually increased as the aggregate particle size decreased. The maximum C:N and C:P ratios were measured in the 0.25-2 mm aggregates, while the maximum N:P ratios was measured occurred in the <0.053 mm aggregates. (2) The stoichiometric ratios had different degrees of relevance associated with the aggregate nutrients, TN and C:N, SOC and C:P, and TP and N:P showed extremely significant linear correlations. Moreover, a significant correlation also occurred between enzyme activity and aggregate nutrients, particularly in macroaggregates. (3) Soil physicochemical properties, such as the soil total porosity, capillary water holding capacity, saturated hydraulic conductivity, bulk density and pH, had a direct influence on enzyme activity, therefore, the soil condition can be improved by changing the planting patterns to promote enzyme activity. These findings are helpful for the optimal allocation of forest and grass for the comprehensive control of karst rocky desertification.
Changes in Tear Proteomic Profile in Ocular Diseases

The search for proteomic biomarkers in ocular disease is one of the most important research directions in recent years. Reliable biomarkers can be an immense adjuvant for both diagnostic and therapeutic approaches. There is no more readily available ocular tissue for proteomic analysis than tear film, which makes an interesting target for the biomarker search. Tear film is a complex fluid consisting of a superficial lipid layer, which covers the aqueous-mucous layer. Its complexity makes it a perfect candidate for all the “omics” approaches. Glaucoma, cataract, age-related macular degeneration, and other diseases are commonly thought to have a multifactorial background. Currently, no reliable non-invasive tests are available that would help physicians with screening and further patient management. The aim of the study is to present modern methods of measuring biomarkers in tears, with particular emphasis on spectrometric methods, and to discuss their diagnostic and therapeutic usefulness.
Have M&A delistings negatively impacted U.S. capital markets? Evidence from the effect on industry peer firms

We provide evidence of negative information spillovers associated with delistings from mergers and acquisitions (M&A delistings), a key factor in the long-term decline in the number of publicly listed firms in the U.S. Specifically, we show that M&A delistings are associated with a decrease in the quality of analysts’ information environment (increased absolute forecast errors and dispersion) for targets’ industry peer firms; these results are stronger when targets are larger, and for public targets than for private targets. Additional tests, including a falsification test using non-completed M&As, suggest that our results are robust to endogeneity concerns arising from industry-level shocks.
Hypervirulence and Multiresistance to Antibiotics in Klebsiella pneumoniae Strains Isolated from Patients with Hospital- and Community-Acquired Infections in a Mexican Medical Center

Klebsiella pneumoniae is a pathogenic bacterium associated with different infectious diseases. This study aimed to establish the different association profiles of virulence genes related to the hypermucoviscous phenotype (HM), capsular serotypes, biofilm formation, and multidrug resistance in K. pneumoniae strains from patients with hospital- and community-acquired infections. K. pneumoniae virulence genes and capsular serotypes were identified by PCR, antibiotic susceptibility by the Kirby–Bauer method, HM by the string test, and biofilm formation by measurement in polystyrene microtiter plates. Of a total of 150 strains from patients with hospital- (n = 25) and community-acquired infections (n = 125), 53.3% (80/150) were HM-positive and 46.7% (70/150) were HM-negative. HM-positive (68/80) and HM-negative (67/70) strains were biofilm-forming. Moreover, 58.7% (47/80) HM-positive and 57.1% (40/70) HM-negative strains were multidrug-resistant. Among HM-positive, HM-negative, and serotypes K1 (25/150), K2 (48/150), and non-K1/K2 strains, (77/150) the frequently detected adhesion genes were fimH, mrkD, ycfM, and kpn; entB, irp2, irp1, and ybtS, for iron acquisition; and rmpA for protectins. The gene association pattern fimH/kpn/mrkD/ycfM/entB/irp1/irp2/ybtS/fyuA (18/150) was frequent among the strains. K. pneumoniae strains from patients with hospital- and community-acquired infections demonstrated a wide diversity of virulence gene profiles related to phenotype (hypermucoviscosity, multidrug resistance, and biofilm formation) and serotypes.
VDR Polymorphic Variants Are Related to Improvements in CRP and Disease Activity in Patients with Axial Spondyloarthritis That Undergo Anti-TNF Treatment

Vitamin D deficiency is related with susceptibility or progression of various autoimmune diseases. The aim of the study was to assess potential relations between single nucleotide polymorphisms (SNPs) in the vitamin D receptor-coding gene (VDR): rs1544410 (BsmI), rs2228570 (FokI), rs731236 (TaqI), rs7975232 (ApaI), and disease activity in patients with axial spondyloarthritis (axSpA) undergoing anti-TNF therapy. The VDR rs731236 CT genotype was statistically more common among female patients (p = 0.027). An improvement of CRP equal to or higher than 50% after 3 months of anti-TNF therapy was observed for rs2228570 T allele (p = 0.002). After 6 months, CRP improvement equal to or higher than 75% was related to presence of the rs1544410 AA genotype (p = 0.027) and the rs731236 CC homozygotes (p = 0.047). Baseline BASDAI values were lower in individuals with the rs2228570 TT genotype (p = 0.036) and rs7975232 C allele (p = 0.029). After 6 months of treatment, lower BASDAI values were observed in AC heterozygotes (p = 0.005). The same AC genotype was more frequently detected in patients with remission (BASDAI ≤ 2) (p = 0.001) and in those achieving BASDAI improvement equal to or higher than 75% (p = 0.006). In conclusion, VDR SNPs were found to relate to CRP and BASDAI values at different time points of anti-TNF therapy.
Cocrystal Prediction of Bexarotene by Graph Convolution Network and Bioavailability Improvement

Bexarotene (BEX) was approved by the FDA in 1999 for the treatment of cutaneous T-cell lymphoma (CTCL). The poor aqueous solubility causes the low bioavailability of the drug and thereby limits the clinical application. In this study, we developed a GCN-based deep learning model (CocrystalGCN) for in-silico screening of the cocrystals of BEX. The results show that our model obtained high performance relative to baseline models. The top 30 of 109 coformer candidates were scored by CocrystalGCN and then validated experimentally. Finally, cocrystals of BEX-pyrazine, BEX-2,5-dimethylpyrazine, BEX-methyl isonicotinate, and BEX-ethyl isonicotinate were successfully obtained. The crystal structures were determined by single-crystal X-ray diffraction. Powder X-ray diffraction, differential scanning calorimetry, and thermogravimetric analysis were utilized to characterize these multi-component forms. All cocrystals present superior solubility and dissolution over the parent drug. The pharmacokinetic studies show that the plasma exposures (AUC0−8h) of BEX-pyrazine and BEX-2,5-dimethylpyrazine are 1.7 and 1.8 times that of the commercially available BEX powder, respectively. This work sets a good example for integrating virtual prediction and experimental screening to discover the new cocrystals of water-insoluble drugs.
Towards Sustainable Medicinal Resources through Marine Soft Coral Aquaculture: Insights into the Chemical Diversity and the Biological Potential

In recent decades, aquaculture techniques for soft corals have made remarkable progress in terms of conditions and productivity. Researchers have been able to obtain larger quantities of soft corals, thus larger quantities of biologically active metabolites, allowing them to study their biological activity in many pharmacological assays and even produce sufficient quantities for clinical trials. In this review, we summarize 201 secondary metabolites that have been identified from cultured soft corals in the era from 2002 to September 2022. Various types of diterpenes (eunicellins, cembranes, spatanes, norcembranes, briaranes, and aquarianes), as well as biscembranes, sterols, and quinones were discovered and subjected to bioactivity investigations in 53 different studies. We also introduce a more in-depth discussion of the potential biological effects (anti-cancer, anti-inflammatory, and anti-microbial) and the mechanisms of action of the identified secondary metabolites. We hope this review will shed light on the untapped potential applications of aquaculture to produce valuable secondary metabolites to tackle current and emerging health conditions.
Protective Effect of D-Panthenol in Rhabdomyolysis-Induced Acute Kidney Injury

We investigated the nephroprotective effect of D-panthenol in rhabdomyolysis-induced acute kidney injury (AKI). Adult male Wistar rats were injected with 50% glycerol solution to induce rhabdomyolysis. Animals with rhabdomyolysis were injected with D-panthenol (200 mg/kg) for 7 days. On day 8, we examined AKI markers, renal histology, antioxidant capacity, and protein glutathionylation in kidneys to uncover mechanisms of D-panthenol effects. Rhabdomyolysis kidneys were shown to have pathomorphological alterations (mononuclear infiltration, dilatation of tubules, and hyaline casts in Henle’s loops and collecting ducts). Activities of skeletal muscle damage markers (creatine kinase and lactate dehydrogenase) increased, myoglobinuria was observed, and creatinine, BUN, and pantetheinase activity in serum and urine rose. Signs of oxidative stress in the kidney tissue of rhabdomyolysis rats, increased levels of lipid peroxidation products, and activities of antioxidant enzymes (SOD, catalase, and glutathione peroxidase) were all alleviated by administration of D-panthenol. Its application improved kidney morphology and decreased AKI markers. Mechanisms of D-panthenol’s beneficial effects were associated with an increase in total coenzyme A levels, activity of Krebs cycle enzymes, and attenuation of protein glutathionylation. D-Panthenol protects kidneys from rhabdomyolysis-induced AKI through antioxidant effects, normalization of mitochondrial metabolism, and modulation of glutathione-dependent signaling.
Evaluation Based on the Distance from the Average Solution Approach: A Derivative Model for Evaluating and Selecting a Construction Manager

In the current market of integration and globalization, the competition between engineering and construction companies is increasing. Construction contractors can improve their competitiveness by evaluating and selecting qualified personnel for the construction engineering manager position for their company’s civil engineering projects. However, most personnel evaluation and selection models in the construction industry rely on qualitative techniques, which leads to unsuitable decisions. To overcome this problem, this paper presents evaluation criteria and proposes a new model for selecting construction managers based on the evaluation based on the distance from the average solution approach (EDASA). The research results showed that EDASA has many strengths, such as solving the problem faster when the number of evaluation criteria or the number of alternatives is increased.
Evaluation of Employee Acceptance of the IMS Application at PT Sarana Utama Adimandiri: TAM Approach

PT Sarana Utama Adimandiri (SUA) which is engaged in the construction sector implements an IMS application in its purchasing activity. This paper aims at describing the evaluation of employee acceptance of the information system at PT SUA using the Technology Acceptance Model (TAM) approach. TAM has two main variables i.e: perceived usefulness and perceived ease of use which function as independent variables, while the dependent variable is acceptance of IT (integrated management system/IMS applications). The population and sample in this study were all employees of PT SUA, which was used to obtain research data through the distribution of structured questionnaires. The instrument was tested using validity and reliability tests, and data was analyzed by using spearman rank test. This study suggests that there is a strong effect of perceived usefulness and perceived ease of use on acceptance of IT.
Quantum Mind: The Edge Between Physics and Psychology

By exploring principles found in psychology, math, physics, and shamanism, it becomes possible to link a cosmic perspective with ordinary life. This comprehensive work ventures into that challenging junction, journeying through the universe on paths of reason and magic, math and myth, bringing together humanity's traditional wisdom and shamanism with contemporary science.
Halo mass function and the free streaming scale

The nature of structure formation around the particle free streaming scale is still far from understood. Many attempts to simulate hot, warm, and cold dark matter cosmologies with a free streaming cuto have been performed with cosmological particlebased simulations, but they all suer from spurious structure formation at scales below their respective free streaming scales { i.e. where the physics of halo formation is most aected by free streaming. We perform a series of high resolution numerical simulations of dierent warm dark matter (WDM) models, and develop an approximate method to subtract articial structures in the measured halo mass function. The corrected measurements are then used to construct and calibrate an extended Press-Schechter (EPS) model with sharp-k window function and adequate mass assignment. The EPS model gives accurate predictions for the low redshift halo mass function of CDM and WDM models, but it signicantly under-predicts the halo abundance at high redshifts. By taking into account the ellipticity of the initial patches and connecting the characteristic lter scale to the smallest ellipsoidal axis, we are able to eliminate this inconsistency and obtain an accurate mass function over all redshifts and all dark matter particle masses covered by the simulations. As an additional application we use our model to predict the microhalo abundance of the standard neutralino-CDM scenario and we give the rst quantitative prediction of the mass function over the full range of scales of CDM structure formation.
To Fix or Not to Fix: Maintenance of Chromosome Ends Versus Repair of DNA Double-Strand Breaks

Early work by Muller and McClintock discovered that the physical ends of linear chromosomes, named telomeres, possess an inherent ability to escape unwarranted fusions. Since then, extensive research has shown that this special feature relies on specialized proteins and structural properties that confer identity to the chromosome ends, thus allowing cells to distinguish them from intrachromosomal DNA double-strand breaks. Due to the inability of conventional DNA replication to fully replicate the chromosome ends and the downregulation of telomerase in most somatic human tissues, telomeres shorten as cells divide and lose this protective capacity. Telomere attrition causes the activation of the DNA damage checkpoint that leads to a cell-cycle arrest and the entering of cells into a nondividing state, called replicative senescence, that acts as a barrier against tumorigenesis. However, downregulation of the checkpoint overcomes this barrier and leads to further genomic instability that, if coupled with re-stabilization of telomeres, can drive tumorigenesis. This review focuses on the key experiments that have been performed in the model organism Saccharomyces cerevisiae to uncover the mechanisms that protect the chromosome ends from eliciting a DNA damage response, the conservation of these pathways in mammals, as well as the consequences of their loss in human cancer.
The use of vinylcyclohexene diepoxide to create diminish ovarian reserve model on rats

Background: Infertility remains a significant issue in the world of health. Now Assisted Reproductive Technology (ART) is widely used to help couples with infertility. In ART diminish ovarian reserve patients have a very low success rate of pregnancy. To help patients with Diminished Ovarian Reserve (DOR), research is conducted using an animal model. vinylcychlohexene diepoxide (VCD) has ovotoxic effects. This study looked at the use of VCD in inducing targeted DOR conditions in animals (rats), create a model that could be used for future animal studies in infertility. Methods: Adult female Rattus norvegicus were used in this study. All were given VCD injections at 80 mg/kg intraperitoneally for 15 days. An examination of Follicle Stimulating Hormone (FSH) levels will be carried out on days 0,3,5,7, and 15. To mimic IVF process, all rats got an injection of 10 IU of Pregnant Mare Serum Gonadotropin (PMSG) and 10 IU human Chorionic Gonadotropin (hCG) to confirm DOR. Ovarectomy was performed, dominant follicles were taken, denudation was carried out, and the oocytes were cultured for 12 hours. Then, oocytes were assessed through a microscope. Results: Starting from day 5 post VCD induction, there was a significant increase in the FSH level in the group of rats that were induced with the administered VCD dose compared to the control group that experienced normal FSH fluctuations. The FSH concentration reached >50%. It was found that the number of degenerated oocytes had an average of 1.11. Oocytes that were in Germinal-Vesicle (GV) stage had an average of 1.89, while in the Metaphase I (M1) stage the average is 2.882. Lastly, the number of oocytes in the Metaphase (MII) stage which is fully matured had an average of 1.117. Conclusions: VCD can become an important tool for future studies that needs an animal model with DOR.
Efficacy of Early Cardiac Rehabilitation After Cardiac Surgery　― Verification Using Japanese Diagnosis Procedure Combination Data ―

Background: The current status of cardiac rehabilitation (CR) after cardiac surgery and the introduction of early CR (E-CR) in Japan are not fully understood. In this study, the current status of E-CR and its efficacy were investigated by the Academic Committee of the Japanese Association of Cardiac Rehabilitation. Methods and Results: We examined the rate of introduction of E-CR and its effects among 220,122 patients who underwent major cardiac and thoracic vascular surgery, as registered in the Diagnosis Procedure Combination (DPC) classification system, between April 2012 and March 2018. In this study, E-CR was defined as CR starting within 1 day after surgery. Patients with and without E-CR were propensity score matched and analyzed for clinical outcomes. Of all patients participating in CR after surgery, E-CR was initiated in 52.1%, 56.9%, 47.4%, and 54.1% of patients undergoing coronary artery bypass grafting, valve surgery, aortic surgery, and other cardiovascular surgery, respectively. After propensity score matching, outcomes for E-CR were significantly superior to non-E-CR in terms of in-hospital deaths, Barthel Index score at discharge, length of hospital stay, and hospitalization costs. Conclusions: E-CR after cardiac surgery was effective in terms of prognosis, hospital stay, and medical costs. This study is the first report using big data in Japan. The results indicate that further introduction of E-CR needs to be recommended in the future.
Changes in the Laser-Processed Ti6Al4V Titanium Alloy Surface Observed by Using Raman Spectroscopy

This works reports on the effects of treating the surface of Ti6Al4V titanium alloy samples with a laser with a wavelength of 1064 nm, operating in a pulsed and continuous mode. The obtained surfaces with different roughness, complexity and wettability were examined by Raman spectroscopy in order to recognize the presence of titanium oxides on the functionalized surface. The layer of titanium oxides on the surface with the identified rutile phase obtained by laser treatment in the continuous wave mode is a reason for a hydrophobic surface that appeared 50 days after the treatment process. In the case of the surface obtained by the pulsed laser process, only local points at which the Raman bands attributed to the metastable phases anatase and brookite of TiO2 can be identified. In this treatment process, complete surface hydrophilicity was observed during 29 days after the functionalization process (maximal contact angle observed during this time was 68.4 deg). For some functionalization processes of different parameters, the contact angle remained immeasurable until 119 days after the functionalization process. In summary, Raman spectroscopy identifies surface changes of Ti6Al4V after laser processing.
STRUCTURAL DYNAMICS MODELING AND MACHINE LEARNING FOR INTEGRAL BLADE ROTOR MILLING

INTRODUCTION In this paper, a Bayesian machine learning framework is developed to model the process dynamics and optimize the milling parameters for an integral blade rotor (IBR), or blisk. The IBR was selected as a use case due to the challenges in machining dynamically compliant designs from wrought or forged stock made from difficult-tomachine materials. Parameter selection requires a model-based approach because: 1) the structural dynamics depend on the tool-holderspindle and workpiece; and 2) the structural dynamics dictate combinations of spindle speed and depth of cut that result in chatter, a selfexcited vibration that causes large cutting forces, poor surface finish, and rapid tool wear. While conservative combinations may be selected, these non-optimal parameters increase cycle time, cost, and energy use.
Research on the Dynamic Evolution
and Improvement Path of Inclusive Green
Development Efficiency in China:
a Perspective of Urban

Rapid urbanization in China has led to resource depletion, environmental pollution, and social inequity. The cornerstone of China’s high-quality economic development is inclusive green development, which has developed as the society’s primary objective. Based on the panel data of 16 prefecture-level cities in Anhui Province from 2011 to 2020, the study explores the connotation of urban inclusive green development efficiency (IGDE) and evaluates IGDE using the hierarchical entropy weight TOPSIS model combined with the global-Super-SBM model. The current situation and problems of IGDE in Anhui Province are thoroughly analyzed, then the Global-Malmquist index is used to analyze the structural dynamics of efficiency dynamics, the Theil index to explore the sources of regional differences in efficiency and the efficiency slackness index to discover the causes of low-efficiency losses. The results indicate that, technological progress is the key factor affecting IGDE. Intra-regional variation is the primary source of regional variation in IGDE. The inadequacy of infrastructure, medical level, educational equity, and green status are the four decisive aspects that cause the low efficiency of IGDE for the whole, but the weaknesses of IGDE are specifically from city to city. According to the above, the practical promotion path of IGDE in Anhui province has been obtained.