Miracle-dz/UniFAR-FTUs huggingface dataset:
Atrial fibrillation type and renal dysfunction as important predictors of left atrial thrombus

Objective We aimed to identify predictors of left atrial appendage (LAA) thrombus in patients with atrial fibrillation (AF) and to enhance the prognostic value of the CHA2DS2-VASc score. Methods Derivation cohort included 1033 consecutive AF patients referred for catheter ablation or direct current cardioversion, in whom transoesophageal echocardiography (TOE) was performed prior to the procedure. Logistic regression analysis was used to identify predictors of LAA thrombus on TOE. Receiver operating characteristic (ROC) curves were constructed to compare the newly developed score with the CHA2DS2 and CHA2DS2-VASc scores in the derivation and the validation (n=320) cohort. Results On TOE, LAA thrombus was present in 59 (5.7%) patients in the derivation cohort. Aside from variables encompassed by the CHA2DS2-VASc score, LAA thrombus predictors included AF type (persistent/’permanent’ vs paroxysmal) and renal dysfunction. These predictors were incorporated into the CHA2DS2-VASc score. In ROC analysis, area under the curve (AUC) for the new score (CHA2DS2-VASc-RAF score) was significantly higher (0.81) than those for the CHA2DS2 and CHA2DS2-VASc scores (0.71 and 0.70, respectively). In the validation cohort, the CHA2DS2-VASc-RAF score also performed significantly better (AUC of 0.88) than the CHA2DS2 and CHA2DS2-VASc scores (AUC of 0.63 and 0.60, respectively). Conclusion In real-world AF patients with majority on oral anticoagulation, LAA thrombus was found in approximately 6%. Two variables not included in the CHA2DS2-VASc score (AF type and renal dysfunction) proved strong, independent predictors of LAA thrombus and might improve thromboembolic risk stratification.
First Order Logic with Inductive Definitions for Model-Based Problem Solving

In answer-set programming (ASP), programs can be viewed as specifications of finite Herbrand structures. Other logics can be (and, in fact, were) used towards the same end and can be taken as the basis of declarative programming systems of similar functionality as ASP. We discuss here one such logic, the logic FO(ID), and its implementation IDP3. The choice is motivated by notable similarities between ASP and FO(ID), even if both approaches trace back to different origins
Food Safety in the Age of Next Generation Sequencing, Bioinformatics, and Open Data Access

Public health labs and food regulatory agencies globally are embracing whole genome sequencing (WGS) as a revolutionary new method that is positioned to replace numerous existing diagnostic and microbial typing technologies with a single new target: the microbial draft genome. The ability to cheaply generate large amounts of microbial genome sequence data, combined with emerging policies of food regulatory and public health institutions making their microbial sequences increasingly available and public, has served to open up the field to the general scientific community. This open data access policy shift has resulted in a proliferation of data being deposited into sequence repositories and of novel bioinformatics software designed to analyze these vast datasets. There also has been a more recent drive for improved data sharing to achieve more effective global surveillance, public health and food safety. Such developments have heightened the need for enhanced analytical systems in order to process and interpret this new type of data in a timely fashion. In this review we outline the emergence of genomics, bioinformatics and open data in the context of food safety. We also survey major efforts to translate genomics and bioinformatics technologies out of the research lab and into routine use in modern food safety labs. We conclude by discussing the challenges and opportunities that remain, including those expected to play a major role in the future of food safety science.
Functional Phenotype of Synovial Monocytes Modulating Inflammatory T-Cell Responses in Rheumatoid Arthritis (RA)

Monocytes function as crucial innate effectors in the pathogenesis of chronic inflammatory diseases, including autoimmunity, as well as in the inflammatory response against infectious pathogens. Human monocytes are heterogeneous and can be classified into three distinct subsets based on CD14 and CD16 expression. Although accumulating evidence suggests distinct functions of monocyte subsets in inflammatory conditions, their pathogenic roles in autoimmune diseases remain unclear. Thus, we investigated the phenotypic and functional characteristics of monocytes derived from synovial fluid and peripheral blood in RA patients in order to explore the pathogenic roles of these cells. In RA patients, CD14+CD16+, but not CD14dimCD16+, monocytes are predominantly expanded in synovial fluid and, to a lesser degree, in peripheral blood. Expression of co-signaling molecules of the B7 family, specifically CD80 and CD276, was markedly elevated on synovial monocytes, while peripheral monocytes of RA and healthy controls did not express these molecules without stimulation. To explore how synovial monocytes might gain these unique properties in the inflammatory milieu of the synovial fluid, peripheral monocytes were exposed to various stimuli. CD16 expression on CD14+ monocytes was clearly induced by TGF-β, although co-treatment with IL-1β, TNF-α, or IL-6 did not result in any additive effects. In contrast, TLR stimulation with LPS or zymosan significantly downregulated CD16 expression such that the CD14+CD16+ monocyte subset could not be identified. Furthermore, treatment of monocytes with IFN-γ resulted in the induction of CD80 and HLA-DR expression even in the presence of TGF-β. An in vitro assay clearly showed that synovial monocytes possess the unique capability to promote Th1 as well as Th17 responses of autologous peripheral CD4 memory T cells. Our findings suggest that the cytokine milieu of the synovial fluid shapes the unique features of synovial monocytes as well as their cardinal role in shaping inflammatory T-cell responses in RA.
Optimizing Queries with Universal Quantification in Object-Oriented and Object-Relational Databases

We investigate the optimization and evaluation of queries with universal quantification in the context of the object-oriented and object-relational data models. The queries are classified into 16 categories depending on the variables referenced in the so-called range and quantifier predicates. For the three most important classes we enumerate the known query evaluation plans and devise some new ones. These alternative plans are primarily based on anti-semijoin, division, generalized grouping with count aggregation, and set difference. In order to evaluate the quality of the many different evaluation plans a thorough performance analysis on some sample database configurations was carried out. The quantitative analysis reveals that-if applicable-the anti-semijoinbased plans are superior to all the other alternatives, even if we employ the most sophisticated division algorithms. Furthermore, exploiting object-oriented features, anti-semijoin plans can be derived even when this is not possible in the relational context.
Phase II study of tariquidar, a selective P‐glycoprotein inhibitor, in patients with chemotherapy‐resistant, advanced breast carcinoma

The primary objective of this study was to determine whether addition of the selective P‐glycoprotein (P‐gp) inhibitor tariquidar (XR9576) to chemotherapy could induce an objective tumor response in patients who previously were resistant to the same agents. The secondary objectives were to evaluate P‐gp expression by immunohistochemistry (IHC), to determine functional activity of the P‐gp transporter before and after administration of tariquidar with serial technetium‐99m (99mTc)‐sestamibi scans, and to correlate those parameters with clinical response.
[The role of urotensin II gene in the genetic susceptibility to type 2 diabetes in Chinese population].

OBJECTIVE To investigate the relationship between the polymorphism of site rs228648 in urotensin II gene and the genetic susceptibility to type 2 diabetes in Han people. METHODS Genotyping was conducted to investigate the polymorphism of site rs228648 (G-A) in urotensin II gene among 166 unrelated type 2 diabetic subjects (case group 1), 87 probands from 87 families of type 2 diabetics (case group 2), and 121 non-diabetic normal controls (control group). RESULTS 1) The frequency of "G" allele of site rs228648 was 62.3% and 75.3% in case group 1 and case group 2 respectively, significantly higher than that in the control group (50.4%, P = 0.004 and P < 0.001). 2) The frequency of G/G genotype of rs228648 was 35% and 53% in case group 1 and case group 2 respectively, significantly higher than that in the control group (24%, P < 0.05 and P < 0.01). The odds ratio was 1.86, P = 0.041 in the case group 1 and 4.03, P < 0.001 in the case control 2 after adjustment by sex, age and BMI. CONCLUSION Urotensin II gene may contribute to the genetic susceptibility to type 2 diabetes in Han population.
A Scale-Consistent Approach for Recommender Systems

In this paper we propose and develop a relatively simple and efficient approach for estimating unknown elements of a user-rating matrix in the context of a recommender system (RS). The critical theoretical property of the method is its consistency with respect to arbitrary units implicitly adopted by different users to construct their quantitative ratings of products. It is argued that this property is needed for robust performance accuracy across a broad spectrum of RS application domains.
Phase I study of intraventricular recombinant tissue plasminogen activator for treatment of posthaemorrhagic hydrocephalus.

AIM: Phase I study to evaluate intraventricular fibrinolytic treatment with recombinant tissue plasminogen activator (tPA) as a method of clearing blood from the cerebrospinal fluid, and thus preventing permanent hydrocephalus. METHODS: Twenty two preterm infants, aged 7 to 26 days, with progressive posthaemorrhagic ventricular dilatation (ventricular width > 4 mm over 97th centile) received one to five intraventricular bolus injections of 1.0 mg or 0.5 mg tPA at intervals of one to seven days. RESULTS: The mean cerebrospinal fluid concentration of tPA 24 hours after 1 mg was 1860 micrograms/ml. The half life of tPA in cerebrospinal fluid was about 24 hours. Twenty one (95%) infants survived, 12 (55%) without shunt surgery. One infant had secondary intraventricular haemorrhage. CONCLUSION: Intraventricular tPA resulted in survival without a shunt for most of the infants, but with some risk. Failure may have been due to plasminogen deficiency, an inhibitor, or late intervention.
The Effect of Self-Regulated and Experimenter-Imposed Practice Schedules on Motor Learning for Tasks of Varying Difficulty

Research suggests that allowing individuals to control their own practice schedule has a positive effect on motor learning. In this experiment we examined the effect of task difficulty and self-regulated practice strategies on motor learning. The task was to move a mouse-operated cursor through pattern arrays that differed in two levels of difficulty. Participants learned either four easy or hard patterns after assignment to one of four groups that ordered practice in blocked, random, self-regulated, and yoked-to-self-regulated schedules. Although self-regulation provided no special benefit in acquisition, these groups showed the most improved performance in retention, irrespective of task difficulty. Although individual switch strategies for members of the self-regulated groups were quite variable, the impact of self-regulation on motor learning remained similar. These findings add to the growing body of literature suggesting that self-regulated practice is an important variable for motor learning.
Forging the Link: The Role of Photographs and Textual Self-Disclosure on Forming Facebook Friendships

Users on social networking sites (SNSs) share visual and textual content which is subsequently viewed by other users that are fonning impressions in order to evaluate potential candidates for friendship. One experiment examined whether the style of photograph and amount of selfdisclosure in the "about me" text ofa user's Facebook profile impact how willing viewers were to initiate friendship with the profile owner. Participants were shown one of six profiles that varied in photographic style (none, neutral expression, smiling expression) and amount oftext self-disclosure (low or high). Results showed that self-disclosure promoted friendship, but photograph style had no effect. This suggests that substantive textual content can be more f important than appearances when making decisions about whom to friend, even when t ! differences in perceived attractiveness are salient. l I '1 I 1
Superoxide dismutase mimetic tempol inhibits hypoxic pulmonary vasoconstriction in rats independently of nitric oxide production

Hypoxic pulmonary vasoconstriction (HPV), an important physiological mechanism, is regulated by changes in the production of and interactions among reactive oxygen species (ROS). There is controversy, however, over whether HPV is mediated by an increase or a decrease in ROS production. Also, the role of NO in HPV remains unclear. The aim of this study was to investigate whether the inhibition of HPV by the antioxidant tempol was dependent on the concentration of NO, and how its effect was influenced by increased basal pulmonary vascular tone. In isolated rat lungs, we measured vasoconstrictor responses to acute ventilatory hypoxia before and after administration of tempol during perfusion with or without l‐NAME. We found that tempol abolished HPV independently of NO production. When we increased basal vascular tone by K+‐induced depolarization, we also found that tempol completely inhibited HPV. Our results indicate that inhibition of HPV by the superoxide dismutase mimetic tempol does not depend on either NO production or a decrease in basal vascular tone.
A theory of speech motor control and supporting data from speakers with normal hearing and with profound hearing loss

A theory of the segmental component of speech motor control is presented, followed by supporting data. According to the theory, speech movements are programmed to achieve auditory/acoustic goals. The goals are determined partly by "saturation effects", which are basic characteristics of speakers' production systems that make it possible to produce a sound output that has some relatively stable acoustic properties despite a somewhat variable motor input. The programming of articulatory movements to achieve auditory goals utilizes an internal model (or "mapping") of relations between articulatory configurations and their acoustic consequences. The internal model is acquired and maintained with the use of auditory feedback. The supporting data for this theory come from experiments on speakers with normal hearing, cochlear implant users and a patient with neurofibromatosis-2.
Epidemiology of ischaemic heart disease in sub-Saharan Africa

Background The epidemiology of ischaemic heart disease (IHD) in sub-Saharan Africa (SSA) remains largely enigmatic. Major obstacles to our understanding of the condition include lack of reliable health statistics, particularly cause-specific mortality data, inadequate diagnostic capabilities, shortage of physicians and cardiologists, and misguided opinions. Methods This review of the epidemiology of ischaemic heart disease in sub-Saharan Africa involved a systematic bibliographic MEDLINE search of published data on IHD in SSA over the past century. Search words included epidemiology, ischaemic (coronary) heart disease, myocardial infarction, cardiovascular risk factors and sub-Saharan Africa. Selected data are presented on the prevalence of cardiovascular risk factors and mortality from ischaemic heart disease from different countries representing the main regions of the continent. Results Although IHD in SSA remains relatively uncommon, its prevalence is predicted to rise in the next two decades due to the rising prevalence of risk factors, especially hypertension, diabetes, overweight and obesity, physical inactivity, increased tobacco use and dyslipidaemia. It is estimated that age-standardised mortality rates for IHD will rise by 27% in African men and 25% in women by 2015, and by 70 and 74%, respectively by 2030. Conclusion Ischaemic heart disease remains relatively uncommon in SSA, despite an increasing prevalence of risk factors, but its incidence is rising. The pace and direction of economic development, rates of urbanisation, and changes in life expectancy resulting from the impact of pre-transitional diseases and violence will be major determinants of the IHD epidemic in SSA. The best window of opportunity for prevention of the emerging epidemic of ischaemic heart disease in sub-Saharan Africa is now.
Engagement and commitment in nurses : associated sociodemographic and labour variables

Objectives: To determine the level of engagement and its relation with six areas of work life in nursing professionals in the city of Huesca, Spain and its association with socio-demographic and labour variables. Materials and Methods: A descriptive, cross-sectional study with a quantitative approach, which involved 305 nurses. Descriptive analysis, bivariate correlations and parametric tests, ANOVA and TStudent. Results: Most participants were women, with children and a partner, with a mean age of 44.98 years (SD 10.86). 35.4% of the sample had high levels of engagement (high levels of energy, involvement and effectiveness). Civil status, employment status of the partner and chronic diseases were related to levels of effectiveness; leisure activities were related to energy levels and involvement. The assessment of the labour climate is related to allthree areas of engagement; age, time in the work unit, years working as a nurse and time in a management position are related to involvement. Conclusions: The study population has high levels of work engagement and consistency between the subscales of working life and the organization, with the exception of the subscale of fairness, since individuals surveyed believe that the organization treats them unfairly.
Detection, Identification, and Distribution of Fungi in Bronchoalveolar Lavage Specimens by Use of Multilocus PCR Coupled with Electrospray Ionization/Mass Spectrometry

ABSTRACT As pulmonary fungal infections continue to increase due to an increasing number of immunocompromised patients, rapid detection and accurate identification of these fungal pathogens are critical. A broad fungal assay was developed by incorporating broad-range multilocus PCR amplification and electrospray ionization/mass spectrometry (PCR/ESI-MS) to detect and identify fungal organisms directly from clinical specimens. The aims of this study were to evaluate the performance of PCR/ESI-MS for detection, identification, and determination of the distribution of fungal organisms in bronchoalveolar lavage (BAL) fluid specimens. The BAL fluid specimens submitted for fungal culture at Vanderbilt University Medical Center between May 2005 and October 2011 were included. Cultures and identification were done using standard procedures. In addition, DNA was extracted from BAL fluid specimens, and fungal DNA amplification/identification were performed by PCR/ESI-MS. The results were compared with those of the standard cultures. A total of 691 nonduplicated BAL fluid specimens with sufficient leftover volume for molecular testing were evaluated using PCR/ESI-MS. Among them, 134 specimens (19.4%) were positive for fungi by both culture and PCR/ESI-MS testing. Of the dual-positive specimens, 125 (93.3%) were positive for Candida and Aspergillus species, with concordances between culture and PCR/ESI-MS results being 84 (67.2%) at the species level and 109 (87.2%) at the genus level. In addition, 243 (35.2%) and 30 (4.3%) specimens were positive only by PCR/ESI-MS or by culture, respectively (odds ratio [OR] = 11.95, 95% confidence interval [CI] = 7.90 to 18.17, P = 0.0000). Codetection of fungal organisms was noted in 23 (3.3%) specimens by PCR/ESI-MS, which was significantly higher than the 4 (0.6%) in which they were noted by culture (OR = 5.91, 95% CI = 1.93 to 20.27, P = 0.0002). Among 53 specimens in which cultures failed because of bacterial overgrowth, at least one fungus was identified in 26 specimens (47.3%) by PCR/ESI-MS. PCR/ESI-MS provides an advanced tool for rapid and sensitive detection, identification, and determination of the distribution of fungal organisms directly from BAL fluid specimens. Moreover, it detected fungal organisms in specimens in which cultures failed because of bacterial overgrowth. The clinical relevance of the significantly higher detection rate of fungal organisms by PCR/ESI-MS merits further investigation.
Technical Issues Affecting the Implementation of US Environmental Protection Agency's Proposed Fish Tissue–Based Aquatic Criterion for Selenium

ABSTRACT The US Environmental Protection Agency is developing a national water quality criterion for selenium that is based on concentrations of the element in fish tissue. Although this approach offers advantages over the current water-based regulations, it also presents new challenges with respect to implementation. A comprehensive protocol that answers the “what, where, and when” is essential with the new tissue-based approach in order to ensure proper acquisition of data that apply to the criterion. Dischargers will need to understand selenium transport, cycling, and bioaccumulation in order to effectively monitor for the criterion and, if necessary, develop site-specific standards. This paper discusses 11 key issues that affect the implementation of a tissue-based criterion, ranging from the selection of fish species to the importance of hydrological units in the sampling design. It also outlines a strategy that incorporates both water column and tissue-based approaches. A national generic safety-net water criterion could be combined with a fish tissue–based criterion for site-specific implementation. For the majority of waters nationwide, National Pollution Discharge Elimination System permitting and other activities associated with the Clean Water Act could continue without the increased expense of sampling and interpreting biological materials. Dischargers would do biotic sampling intermittently (not a routine monitoring burden) on fish tissue relative to the fish tissue criterion. Only when the fish tissue criterion is exceeded would a full site-specific analysis including development of intermedia translation factors be necessary.
Christian Clients’ Preferences regarding Prayer as a Counseling Intervention

Spirituality has increasingly become a consideration for mental health practitioners. As a result, spiritual interventions, including prayer, are now more frequently used in counseling. However, no research has explored Christian clients’ expectations regarding prayer in counseling. This study surveyed first-visit Christian clients and their therapists to ascertain client expectations and therapist beliefs and practices. Analysis with two sample t-tests with unequal variances, one-way analysis of variance, simple linear regression, Pearson correlations, and Fisher's exact tests indicated that (a) 82% of clients desired audible prayer in counseling; (b) they preferred that therapists introduce the subject of prayer; (c) they had strong expectations that prayer would be included in counseling; (d) they wanted counselors to pray for them outside of session; (e) religious conservatives had higher expectations for prayer than did liberals; (f) clients with prior Christian counseling had higher expectations of prayer than did clients without. Research implications are discussed.