Miracle-dz/UniFAR-FTUs huggingface dataset:
Rehumanized Crowdsourcing: A Labeling Framework Addressing Bias and Ethics in Machine Learning

The increased use of machine learning in recent years led to large volumes of data being manually labeled via crowdsourcing microtasks completed by humans. This brought about dehumanization effects, namely, when task requesters overlook the humans behind the task, leading to issues of ethics (e.g., unfair payment) and amplification of human biases, which are transferred into training data and affect machine learning in the real world. We propose a framework that allocates microtasks considering human factors of workers such as demographics and compensation. We deployed our framework to a popular crowdsourcing platform and conducted experiments with 1,919 workers collecting 160,345 human judgments. By routing microtasks to workers based on demographics and appropriate pay, our framework mitigates biases in the contributor sample and increases the hourly pay given to contributors. We discuss potential extensions and how it can promote transparency in crowdsourcing.
A Developmental Network Theory of Gynandromorphs, Sexual Dimorphism and Species Formation

Gynandromorphs are creatures where at least two di erent body sections are a di erent sex. Bilateral gynandromorphs are half male and half female. Here we develop a theory of gynandromorph ontogeny based on developmental control networks. The theory explains the embryogenesis of all known variations of gynandromorphs found in multicellular organisms. The theory also predicts a large variety of more subtle gynandromorphic morphologies yet to be discovered. The network theory of gynandromorph development has direct relevance to understanding sexual dimorphism (di erences in morphology between male and female organisms of the same species) and medical pathologies such as hemihyperplasia (asymmetric development of normally symmetric body parts in a unisexual individual). The network theory of gynandromorphs brings up fundamental open questions about developmental control in ontogeny. This in turn suggests a new theory of the origin and evolution of species that is based on cooperative interactions and conflicts between developmental control networks in the haploid genomes and epigenomes of potential sexual partners for reproduction. This network-based theory of the origin of species is a paradigmatic shift in our understanding of evolutionary processes that goes beyond gene-centered theories.
Mechanisms of Activation of Voltage-Gated Potassium Channels

Voltage-gated potassium ion channels (Kv) play an important role in a variety of cellular processes, including the functioning of excitable cells, regulation of apoptosis, cell growth and differentiation, the release of neurotransmitters and hormones, maintenance of cardiac activity, etc. Failure in the functioning of Kv channels leads to severe genetic disorders and the development of tumors, including malignant ones. Understanding the mechanisms underlying Kv channels functioning is a key factor in determining the cause of the diseases associated with mutations in the channels, and in the search for new drugs. The mechanism of activation of the channels is a topic of ongoing debate, and a consensus on the issue has not yet been reached. This review discusses the key stages in studying the mechanisms of functioning of Kv channels and describes the basic models of their activation known to date.
COLUMBIA-IBM NEWS VIDEO STORY SEGMENTATION IN TRECVID 2004

In this technical report, we give an overview of our technical developments in the story segmentation task in TRECVID 2004. Among them, we propose an information-theoretic framework, visual cue cluster construction (VC), to automatically discover adequate mid-level features. The problem is posed as mutual information maximization, through which optimal cue clusters are discovered to preserve the highest information about the semantic labels. We extend the Information Bottleneck framework to high-dimensional continuous features and further propose a projection method to map each video into probabilistic memberships over all the cue clusters. The biggest advantage of the proposed approach is to remove the dependence on the manual process in choosing the mid-level features and the huge labor cost involved in annotating the training corpus for training the detector of each mid-level feature. When tested in TRECVID 2004 news video story segmentation, the proposed approach achieves promising performance gain over representations derived from conventional clustering techniques and even the mid-level features selected manually; meanwhile, it achieved one of the top performances, F1=0.65, close to the highest performance, F1=0.69, by other groups. We also experiment with other promising visual features and continue investigating effective prosody features. The introduction of post-processing also provides practical improvements. Furthermore, the fusion from other modalities, such as speech prosody features and ASR-based segmentation scores are significant and have been confirmed again in this experiment.
3.5–0.5V input, 1.0V output multi-mode power transformer for a supercapacitor power source with a peak efficiency of 70.4%

A multi-mode 3.5-0.5V input, 1.0V output power transformer based on switched-capacitor DC-DC converters is designed to extract 98% of the energy from a 80mF supercapac-itor, to power a periodically active RFID tag. Six converter modes (3 step-up and 3 step-down) are automatically selected depending on the input voltage. The system usage time is maximized by charging the supercapacitor to 3.5V while device breakdown is avoided via novel circuit techniques. The circuit fabricated in TSMC's 65nm GP process occupies an area of 0.48mm2, supports a 3. 3μA load current and operates at 2.0MHz. The gradually decreasing 3.5V to 0.5V supercapacitor voltage is transformed to a steady 1V output with a peak efficiency of 70.4%.
Nephrolithiasis: Molecular Mechanism of Renal Stone Formation and the Critical Role Played by Modulators

Urinary stone disease is an ailment that has afflicted human kind for many centuries. Nephrolithiasis is a significant clinical problem in everyday practice with a subsequent burden for the health system. Nephrolithiasis remains a chronic disease and our fundamental understanding of the pathogenesis of stones as well as their prevention and cure still remains rudimentary. Regardless of the fact that supersaturation of stone-forming salts in urine is essential, abundance of these salts by itself will not always result in stone formation. The pathogenesis of calcium oxalate stone formation is a multistep process and essentially includes nucleation, crystal growth, crystal aggregation, and crystal retention. Various substances in the body have an effect on one or more of the above stone-forming processes, thereby influencing a person's ability to promote or prevent stone formation. Promoters facilitate the stone formation while inhibitors prevent it. Besides low urine volume and low urine pH, high calcium, sodium, oxalate and urate are also known to promote calcium oxalate stone formation. Many inorganic (citrate, magnesium) and organic substances (nephrocalcin, urinary prothrombin fragment-1, osteopontin) are known to inhibit stone formation. This review presents a comprehensive account of the mechanism of renal stone formation and the role of inhibitors/promoters in calcium oxalate crystallisation.
Study of Hypertensive Intracerebral Bleeds and Surgical Outcome

Hypertensive intra cerebral bleeds is the commonest cause of hemorrhagic stroke with high mortality. The decision about the surgical intervention in intra cerebral hematoma remains controversial. Aim of this study was to evaluate the age incidence, clinical presentation, and surgical outcome and mortality due to hypertensive intra cerebral bleeds. This study was conducted Department of Neurosurgery, Osmania General Hospital, Hyderabad from June 2011 to Dec 2014, 38 cases of hypertensive intra cerebral bleeds during the above period in whom the surgical evacuation of hypertensive intra cerebral bleeds were done are included in the study. Age/sex, presenting GCS and the site of hematoma was noted. The outcome of the patients was categorized in terms of mortality and complications. Thirty eight adult patients meeting the inclusion criteria were included in this study, basal ganglia is the commonest site of bleed with male predominate, 5 and 6 decade is commonly affected, patients with GCS less than 6 are having higher mortality.
Matrix-Assisted Laser Desorption Ionization–Time of Flight and Comparative Genomic Analysis of M-18 Group A Streptococcus Strains Associated with an Acute Rheumatic Fever Outbreak in Northeast Italy in 2012 and 2013

ABSTRACT Acute rheumatic fever (ARF) is a postsuppurative sequela caused by Streptococcus pyogenes infections affecting school-age children. We describe here the occurrence of an ARF outbreak that occurred in Bologna province, northeastern Italy, between November 2012 and May 2013. Molecular analysis revealed that ARF-related group A Streptococcus (GAS) strains belonged to the M-18 serotype, including subtypes emm18.29 and emm18.32. All M-18 GAS strains shared the same antigenic profile, including SpeA, SpeB, SpeC, SpeL, SpeM, and SmeZ. Matrix-assisted laser desorption ionization–time of flight (MALDI-TOF) analysis revealed that M-18 GAS strains grouped separately from other serotypes, suggesting a different S. pyogenes lineage. Single nucleotide polymorphisms and phylogenetic analysis based on whole-genome sequencing showed that emm18.29 and emm18.32 GAS strains clustered in two distinct groups, highlighting genetic variations between these subtypes. Comparative analysis revealed a similar genome architecture between emm18.29 and emm18.32 strains that differed from noninvasive emm18.0 strains. The major sources of differences between M-18 genomes were attributable to the prophage elements. Prophage regions contained several virulence factors that could have contributed to the pathogenic potential of emm18.29 and emm18.32 strains. Notably, phage ΦSPBO. 1 carried erythrogenic toxin A gene (speA1) in six ARF-related M-18 GAS strains but not in emm18.0 strains. In addition, a phage-encoded hyaluronidase gene (hylP.2) presented different variants among M-18 GAS strains by showing internal deletions located in the α-helical and TSβH regions. In conclusion, our study yielded insights into the genome structure of M-18 GAS strains responsible for the ARF outbreak in Italy, thus expanding our knowledge of this serotype.
DEBRIS DISKS IN THE SCORPIUS–CENTAURUS OB ASSOCIATION RESOLVED BY ALMA

We present a CO(2-1) and 1240 μm continuum survey of 23 debris disks with spectral types B9-G1, observed at an angular resolution of 0. ″5–1″ with the Atacama Large Millimeter/Submillimeter Array (ALMA). The sample was selected for large infrared excess and age ∼10 Myr, to characterize the prevalence of molecular gas emission in young debris disks. We identify three CO-rich debris disks, plus two additional tentative (3σ) CO detections. Twenty disks were detected in the continuum at the >3σ level. For the 12 disks in the sample that are spatially resolved by our observations, we perform an independent analysis of the interferometric continuum visibilities to constrain the basic dust disk geometry, as well as a simultaneous analysis of the visibilities and broadband spectral energy distribution to constrain the characteristic grain size and disk mass. The gas-rich debris disks exhibit preferentially larger outer radii in their dust disks, and a higher prevalence of characteristic grain sizes smaller than the blowout size. The gas-rich disks do not exhibit preferentially larger dust masses, contrary to expectations for a scenario in which a higher cometary destruction rate would be expected to result in a larger mass of both CO and dust. The three debris disks in our sample with strong CO detections are all around A stars: the conditions in disks around intermediate-mass stars appear to be the most conducive to the survival or formation of CO.
Thermal-controlled releasing and assembling of functional nanomembranes through polymer pyrolysis

Pyrolysis, which involves thermal decomposition of materials at elevated temperatures, has been commonly applied in the chemical industry. Here we explored the pyrolysis process for 3D nanofabrication. By strain engineering of nanomembranes on a thermal responsive polymer as the sacrificial layer, we demonstrated that diverse 3D rolled-up microstructures with different functions could be achieved without any additional solution and drying process. We carefully studied the effect of molecular weight of the polymer in the pyrolysis process and identified that the rapid breakdown of molecular backbone to a monomer is the key for nanomembrane releasing and rolling. Preferential rolling direction and corresponding dynamics were studied by analyzing the real-time video of the rolling process. We further demonstrated the versatile functions of the fabricated 3D structures as catalytic microengines and optical resonators. The simple fabrication methodology developed here may have great potential in producing functional 3D tubular micro-/nanostructures.
An analysis of sentiments on facebook during the 2016 U.S. presidential election

Social networking sites (SNS), such as Facebook and Twitter, are important spaces for political engagement. SNS have become common elements in political participation, campaigns, and elections. However, little is known about the dynamics between candidate posts and commentator sentiment in response to those posts on SNS. This study enriches computational political science by studying the 2016 U.S. elections and how candidates and commentators engage on Facebook. This paper also examines how online activity might be connected to offline activity and vice versa. We extracted 9,700 Facebook posts by five presidential candidates (Hillary Clinton, Donald Trump, Bernie Sanders, Ted Cruz, and John Kasich) from their official Facebook pages and 12,050,595 comments on those posts. We employed topic modeling, sentiment analysis, and trends detection using wavelet transforms to discover topics, trends, and reactions. Our findings suggest that Republican candidates are more likely to share information on controversial events that have taken place during the election cycle, while Democratic candidates focus on social policy issues. As expected, commentators on Republican candidate pages express negative sentiments toward current public policies as they seldom support decisions made by the Obama administration, while commentators on democratic candidate pages are more likely to express support for continuation or advancement of existing policies. However, the significance (strong/weak) and nature (positive/negative) of sentiments varied between candidates within political parties based on perceived credibility of the candidate's degree of credibility on a given issue. Additionally, we explored correlation between online trends of comments/sentiment and offline events. When analyzing the trend patterns, we found that changes in online trends are driven by three factors: 1) popular post, 2) offline debates, and 3) candidates dropping out of the race.
Preferential growth of ZnO thin films by the atomic layer deposition technique

Preferred orientation of ZnO thin films deposited by the atomic layer deposition (ALD) technique could be manipulated by deposition temperature. In this work, diethyl zinc (DEZn) and deionized water (H2O) were used as a zinc source and oxygen source, respectively. The results demonstrated that (10.0) dominant ZnO thin films were grown in the temperature range of 155–220 °C. The c-axis crystal growth of these films was greatly suppressed. Adhesion of anions (such as fragments of an ethyl group) on the (00.2) polar surface of the ZnO thin film was believed to be responsible for this suppression. In contrast, (00.2) dominant ZnO thin films were obtained between 220 and 300 °C. The preferred orientations of (10.0) and (00.2) of the ZnO thin films were examined by XRD texture analysis. The texture analysis results agreed well with the alignments of ZnO nanowires (NWs) which were grown from these ZnO thin films. In this case, the nanosized crystals of ZnO thin films acted as seeds for the growth of ZnO nanowires (NWs) by chemical vapor deposition (CVD) process. The highly (00.2) textured ZnO thin films deposited at high temperatures, such as 280 °C, contained polycrystals with the c axis perpendicular to the substrate surface and provided a good template for the growth of vertically aligned ZnO NWs.
Induction of immunological antitumor effects by adenovirus-mediated gene transfer of B7-1 in a murine squamous cell carcinoma cell line.

OBJECTIVE To evaluate the antitumor immune effects of B7-1 gene expression mediated by adenoviral vectors against squamous cell carcinoma. Transfection of the costimulatory molecule B7-1 gene into certain murine tumors increases antitumor immunity and suppresses tumor growth. DESIGN In vitro and in vivo study. INTERVENTIONS A murine squamous cell carcinoma cell line, KLN205, was infected with adenoviral vectors carrying either B7-1 (AdB7) or LacZ (AdCL) genes. Infected cells were injected subcutaneously into the flanks of DBA/2 mice. MAIN OUTCOME MEASURES The growth of tumors infected with adenviral vectors was measured. RESULTS AdB7-infected cells grew significantly slower than AdCL-infected cells in vivo, while there was no significant difference in the growth rates between the 2 groups in vitro. Moreover, significant growth suppression of rechallenged noninfected parental cells was observed in the mice immunized with AdB7-infected cells but not in those immunized with AdCL-infected cells. CONCLUSION These results suggest that the B7-1 gene has therapeutic potential for immunotherapy against head and neck squamous cell carcinoma.
Hemoglobin Kirklareli (α H58L), a New Variant Associated with Iron Deficiency and Increased CO Binding*

Mutations in hemoglobin can cause a wide range of phenotypic outcomes, including anemia due to protein instability and red cell lysis. Uncovering the biochemical basis for these phenotypes can provide new insights into hemoglobin structure and function as well as identify new therapeutic opportunities. We report here a new hemoglobin α chain variant in a female patient with mild anemia, whose father also carries the trait and is from the Turkish city of Kirklareli. Both the patient and her father had a His-58(E7) → Leu mutation in α1. Surprisingly, the patient's father is not anemic, but he is a smoker with high levels of HbCO (∼16%). To understand these phenotypes, we examined recombinant human Hb (rHb) Kirklareli containing the α H58L replacement. Mutant α subunits containing Leu-58(E7) autoxidize ∼8 times and lose hemin ∼200 times more rapidly than native α subunits, causing the oxygenated form of rHb Kirklareli to denature very rapidly under physiological conditions. The crystal structure of rHb Kirklareli shows that the α H58L replacement creates a completely apolar active site, which prevents electrostatic stabilization of bound O2, promotes autoxidation, and enhances hemin dissociation by inhibiting water coordination to the Fe(III) atom. At the same time, the mutant α subunit has an ∼80,000-fold higher affinity for CO than O2, causing it to rapidly take up and retain carbon monoxide, which prevents denaturation both in vitro and in vivo and explains the phenotypic differences between the father, who is a smoker, and his daughter.
Effect of Celecoxib on Cardiovascular Events and Blood Pressure in Two Trials for the Prevention of Colorectal Adenomas

Background— Cyclooxygenase-2 (COX-2) inhibitors have been shown to reduce colorectal adenomas but have been associated with increased cardiovascular risk. Methods and Results— The Adenoma Prevention With Celecoxib (APC) trial studied celecoxib 200 mg twice daily and 400 mg twice daily and the Prevention of Spontaneous Adenomatous Polyps (PreSAP) trial used 400 mg once daily to test the efficacy and safety of celecoxib against placebo in reducing colorectal adenoma recurrence after polypectomy. An independent safety committee for both studies adjudicated and categorized serious cardiovascular events and then combined individual patient data from these long-term trials to improve the estimate of the cardiovascular risk and blood pressure changes associated with celecoxib compared with placebo. For adjudicated cardiovascular events, 77% and 54% in APC and PreSAP, respectively, had 37 months of follow-up. For APC and PreSAP combined, 83 patients experienced cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or heart failure. The hazard ratio for this prespecified composite end point was 2.6 (95% confidence interval [CI], 1.1 to 6.1) in patients taking 200 mg twice daily, 3.4 (95% CI, 1.5 to 7.9) in patients taking 400 mg twice daily in APC, and 1.3 (95% CI, 0.6 to 2.6) in patients taking 400 mg once daily in PreSAP (P for heterogeneity=0.13 comparing the combined doses in APC with the dose in PreSAP). The overall hazard ratio for this composite end point was 1.9 (95% CI, 1.1 to 3.1). Both dose groups in APC showed significant systolic blood pressure elevations at 1 and 3 years (200 mg twice daily: 1 year, 2.0 mm Hg; 3 years, 2.6 mm Hg; 400 mg twice daily: 1 year, 2.9 mm Hg; 3 years, 5.2 mm Hg); however, the 400 mg once daily group in PreSAP did not (P<0.0001 between studies). Conclusions— Celecoxib at 200 or 400 mg twice daily or 400 mg once daily showed a nearly 2-fold–increased cardiovascular risk. The trend for a dose-related increase in cardiovascular events and blood pressure raises the possibility that lower doses or other dose intervals may be associated with less cardiovascular risk.
Influence of surface charge on the potential toxicity of PLGA nanoparticles towards Calu-3 cells

Background Because of the described hazards related to inhalation of manufactured nanoparticles, we investigated the lung toxicity of biodegradable poly (lactide-co-glycolide) (PLGA) nanoparticles displaying various surface properties on human bronchial Calu-3 cells. Methods Positively and negatively charged as well as neutral nanoparticles were tailored by coating their surface with chitosan, Poloxamer, or poly (vinyl alcohol), respectively. Nanoparticles were characterized in terms of size, zeta potential, and surface chemical composition, confirming modifications provided by hydrophilic polymers. Results Although nanoparticle internalization by lung cells was clearly demonstrated, the cytotoxicity of the nanoparticles was very limited, with an absence of inflammatory response, regardless of the surface properties of the PLGA nanoparticles. Conclusion These in vitro results highlight the safety of biodegradable PLGA nanoparticles in the bronchial epithelium and provide initial data on their potential effects and the risks associated with their use as nanomedicines.