Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical and angiographic evaluation of the resolute zotarolimus-eluting coronary stent in Japanese patients – long-term outcome in the RESOLUTE Japan and RESOLUTE Japan small vessel study.

BACKGROUND This study evaluated the safety and efficacy of the RESOLUTE(TM)zotarolimus-eluting stent (R-ZES; Medtronic, Inc, Santa Rosa, CA, USA) in Japanese patients for the treatment of de novo native coronary lesions. METHODS AND RESULTS Both RESOLUTE Japan (R-Japan) and RESOLUTE Japan Small Vessel Study (R-Japan SVS) were prospective, multicenter, single-arm observational studies. R-Japan enrolled 100 patients (reference vessel diameter, 2.5-3.5 mm) and R-Japan SVS enrolled 65 patients (at least 1 lesion suitable for 2.25-mm stent) treated with R-ZES. In R-Japan, in-stent late lumen loss (LLL; the primary endpoint) at 8 months was 0.12 ± 0.22 mm and volume obstruction on intravascular ultrasound was 2.33 ± 3.51%. At 4 years, there were no cases of clinically driven target lesion revascularization (TLR); the target lesion failure (TLF; composite of cardiac death, target vessel myocardial infarction, and clinically driven TLR) was 5.6% (5/90). In R-Japan SVS, in-stent LLL at 9 months was 0.27 ± 0.33 mm, TLF (primary endpoint) was 4.6% (3/65), without incidence of TLR. At 3 years, TLF was 7.9% (5/63) and clinically driven TLR, 3.2% (2/63). CONCLUSIONS R-Japan and R-Japan SVS demonstrate substantial suppression of neointimal hyperplasia, low LLL, and excellent and sustained long-term clinical outcome with R-ZES in Japanese patients.
Open-Ended Versus Multiple-Choice Response Formats—It Does Make a Difference for Diagnostic Purposes

The purpose of the present study was to examine the effect of response format—open-ended (OE) versus multiple-choice (Me)—on the diagnosis of examinee misconceptions in a procedural task. A test in fraction addition arithmetic was administered to 285 eighth- grade students, 148 of whom responded to the OE ver sion of the test and 137 to the MC version. The two datasets were compared with respect to the underlying structure of the test, the number of different error types, and the diagnosed sources of misconception (bugs) reflected in the response patterns. The overall results indicated considerable differences between the two formats, with more favorable results for the OE format.
The Effects of Sexual Social Marketing Appeals on Cognitive Processing and Persuasion

Abstract Increasingly, social marketers are using sexual information in public service announcements and collateral material for a wide range of causes. This study builds on previous research to explain how sexual appeals can affect cognitive processing and persuasion for “help-self” social marketing topics. It also goes beyond traditional single-message research designs by testing matched pairs of appeals (sexual/nonsexual) for 13 social marketing topics. The major finding was that sexual appeals were more persuasive overall than matched nonsexual appeals for social marketing topics. Sexual appeals also stimulated more favorable ad execution related thoughts but had a negative effect on cognitive elaboration (e.g., support and counterarguments). Respondents also reported that sexual appeals were more attention getting, likeable, dynamic, and somewhat more apt to increase their interest in the topic than were nonsexual appeals. These findings suggest that persuasion is largely the result of peripheral processing and distraction from somewhat unpleasant messages when receivers are expected to counterargue the message or be resistant to change.
Rethinking Chinese Word Segmentation: Tokenization, Character Classification, or Wordbreak Identification

This paper addresses two remaining challenges in Chinese word segmentation. The challenge in HLT is to find a robust segmentation method that requires no prior lexical knowledge and no extensive training to adapt to new types of data. The challenge in modelling human cognition and acquisition it to segment words efficiently without using knowledge of wordhood. We propose a radical method of word segmentation to meet both challenges. The most critical concept that we introduce is that Chinese word segmentation is the classification of a string of character-boundaries (CB's) into either word-boundaries (WB's) and non-word-boundaries. In Chinese, CB's are delimited and distributed in between two characters. Hence we can use the distributional properties of CB among the background character strings to predict which CB's are WB's.
Diagnosis and Management of Grain-Induced Asthma

Grain-induced asthma is a frequent occupational allergic disease mainly caused by inhalation of cereal flour or powder. The main professions affected are bakers, confectioners, pastry factory workers, millers, farmers, and cereal handlers. This disorder is usually due to an IgE-mediated allergic response to inhalation of cereal flour proteins. The major causative allergens of grain-related asthma are proteins derived from wheat, rye and barley flour, although baking additives, such as fungal α-amylase are also important. This review deals with the current diagnosis and treatment of grain-induced asthma, emphasizing the role of cereal allergens as molecular tools to enhance diagnosis and management of this disorder. Asthma-like symptoms caused by endotoxin exposure among grain workers are beyond the scope of this review. Progress is being made in the characterization of grain and bakery allergens, particularly cereal-derived allergens, as well as in the standardization of allergy tests. Salt-soluble proteins (albumins plus globulins), particularly members of the α-amylase/trypsin inhibitor family, thioredoxins, peroxidase, lipid transfer protein and other soluble enzymes show the strongest IgE reactivities in wheat flour. In addition, prolamins (not extractable by salt solutions) have also been claimed as potential allergens. However, the large variability of IgE-binding patterns of cereal proteins among patients with grain-induced asthma, together with the great differences in the concentrations of potential allergens observed in commercial cereal extracts used for diagnosis, highlight the necessity to standardize and improve the diagnostic tools. Removal from exposure to the offending agents is the cornerstone of the management of grain-induced asthma. The availability of purified allergens should be very helpful for a more refined diagnosis, and new immunomodulatory treatments, including allergen immunotherapy and biological drugs, should aid in the management of patients with this disorder.
Effects of Metalloproteinase Inhibition in a Murine Model of Renal Ischemia-Reperfusion Injury

Ischemia-reperfusion injury (IRI) is a leading cause of acute tubular necrosis (ATN) and delayed graft function in transplanted organs. Up-regulation of matrix metalloproteinases (MMPs) propagates the microinflammatory response that drives IRI. This study sought to determine the specific effects of Marimastat (Vernalis, BB-2516), a broad spectrum MMP and TNF-α-converting enzyme inhibitor, on IRI-induced ATN. Mice were pretreated with Marimastat or methylcellulose vehicle for 4 d before surgery. Renal pedicles were bilaterally occluded for 30 min and allowed to reperfuse for 24 h. Baseline creatinine levels were consistent between experimental groups; however, post-IRI creatinine levels were 4-fold higher in control mice (p < 0.0001). The mean difference between the post-IRI histology grades of Marimastat-treated and control kidneys was 1.57 (p = 0.003), demonstrating more severe damage to control kidneys. Post-IRI mean (±SEM) MMP-2 activity rose from baseline levels in control mice (3.62 ± 0.99); however, pretreated mice presented only a slight increase in mean MMP-2 activity (1.57 ± 0.72) (p < 0.001). In conclusion, these data demonstrate that MMP inhibition is associated with a reduction of IRI in a murine model.
Emotions for Strategic Real-Time Systems

Strategic real-time systems are of high potential and their applications are growing, although they are mostly prevalent in video games, military training, and military planning. We propose a paradigm to advance current systems by introducing emotions into the simulated agents that make decisions and solve situations cooperatively. By utilizing emotional reactions and communication, we hope to advance these systems so that the decision process better mimics human behavior. Since our system allows sharing of emotions with nearby agents it utilizes both internal and external emotional control.
Inhibition of Activity-Dependent Arc Protein Expression in the Rat Hippocampus Impairs the Maintenance of Long-Term Potentiation and the Consolidation of Long-Term Memory

It is widely believed that the brain processes information and stores memories by modifying and stabilizing synaptic connections between neurons. In experimental models of synaptic plasticity, such as long-term potentiation (LTP), the stabilization of changes in synaptic strength requires rapid de novo RNA and protein synthesis. Candidate genes, which could underlie activity-dependent plasticity, have been identified on the basis of their rapid induction in brain neurons. Immediate-early genes (IEGs) are induced in hippocampal neurons by high-frequency electrical stimulation that induces LTP and by behavioral training that results in long-term memory (LTM) formation. Here, we investigated the role of the IEGArc (also termed Arg3.1) in hippocampal plasticity. Arc protein is known to be enriched in dendrites of hippocampal neurons where it associates with cytoskeletal proteins (Lyford et al., 1995). Arc is also notable in that its mRNA and protein accumulate in dendrites at sites of recent synaptic activity (Steward et al., 1998). We used intrahippocampal infusions of antisense oligodeoxynucleotides to inhibit Arc protein expression and examined the effect of this treatment on both LTP and spatial learning. Our studies show that disruption of Arc protein expression impairs the maintenance phase of LTP without affecting its induction and impairs consolidation of LTM for spatial water task training without affecting task acquisition or short-term memory. Thus, Arc appears to play a fundamental role in the stabilization of activity-dependent hippocampal plasticity.
Unexpectedly low recombination rates and presence of hotspots in termite genomes

Meiotic recombination is a fundamental evolutionary process that facilitates adaptation and the removal of deleterious genetic variation. Social Hymenoptera exhibit some of the highest recombination rates among metazoans, whereas high recombination rates have not been found among non-social species from this insect order. It is unknown whether elevated recombination rates are a ubiquitous feature of all social insects. In many metazoan taxa, recombination is mainly restricted to hotspots a few kilobases in length. However, little is known about the prevalence of recombination hotspots in insect genomes. Here we infer recombination rate and its fine-scale variation across the genomes of two social species from the insect order Blattodea: the termites Cryptotermes secundus and Macrotermes bellicosus. We used linkage-disequilibrium-based methods to infer recombination rate. We infer that recombination rates are less than 1 cM/Mb in both species, which is lower than the average metazoan rate. We also observed a highly punctate distribution of recombination in both termite genomes, indicative of the presence of recombination hotspots. We infer the presence of full-length PRDM9 genes in the genomes of both species. We also find that recombination rates in genes are correlated with inferred levels of germline DNA methylation. The finding of low recombination rates in termites indicates that eusociality is not universally connected to elevated recombination rate. We speculate that intense selection among haploid males promotes high recombination rates in social Hymenoptera. This study is one of the first to indicate the presence of PRDM9-based recombination hotspots in an insect genome.
Maternal Adaptive Immune Cells in Decidua Parietalis Display a More Activated and Coinhibitory Phenotype Compared to Decidua Basalis

The maternal part of the placenta, the decidua, consists of maternal immune cells, decidual stromal cells, and extravillous fetal trophoblasts. In a successful pregnancy, these cell compartments interact to provide an intricate balance between fetal tolerance and antimicrobial defense. These processes are still poorly characterized in the two anatomically different decidual tissues, basalis and parietalis. We examined immune cells from decidua basalis and parietalis from term placentas (n = 15) with flow cytometry. By using multivariate discriminant analysis, we found a clear separation between the two decidual compartments based on the 81 investigated parameters. Decidua parietalis lymphocytes displayed a more activated phenotype with a higher expression of coinhibitory markers than those isolated from basalis and contained higher frequencies of T regulatory cells. Decidua basalis contained higher proportions of monocytes, B cells, and mucosal-associated invariant T (MAIT) cells. The basalis B cells were more immature, and parietalis MAIT cells showed a more activated phenotype. Conventional T cells, NK cells, and MAIT cells from both compartments potently responded with the production of interferon-γ and/or cytotoxic molecules in response to stimulation. To conclude, leukocytes in decidua basalis and parietalis displayed remarkable phenotypic disparities, indicating that the corresponding stromal microenvironments provide different immunoregulatory signals.
Blood Pressure, Not Cardiac Output, Determines Blood Loss during Induced Hypotension

Cardiac output characteristically decreases during trimethaphan infusion but is well maintained or increased during sodium nitroprusside infusion. We postulated that at similar levels of mean arterial pressure, sodium nitroprusside might be associated with greater blood loss than trimethaphan due to the increase in cardiac output. We studied 20 young healthy patients scheduled for bilateral sagittal osteotomies of the mandible. Ten subjects received trimethaphan and 10 subjects received sodium nitroprusside. Using halothane (0.8% to 1%) and nitrous oxide (60%) for maintenance of anesthesia, trimethaphan or sodium nitroprusside was infused to maintain mean arterial pressure between 55 to 60 torr. Cardiac output was measured in five subjects in each group. Heart rate and cardiac output increased significantly and total peripheral resistance decreased significantly during sodium nitroprusside infusion when compared to trimethaphan infusion. There were no significant differences in duration of hypotension or in blood loss. We conclude that operative blood loss during induced hypotension is determined by mean arterial pressure, not cardiac output.
Low power and high receiving sensitivity wireless wake-up receiver with 2-stage power-supply control scheme for lithium-ion battery systems

A wireless wake-up receiver for lithium-ion battery systems was developed and evaluated. A 2-stage power-supply control scheme is added to the wake-up receiver for supporting low power, high receiving sensitivity, and short wake-up time simultaneously. When the battery system is in power-down mode, only a voltage detector in the wake-up receiver consumes a current while waiting for a wireless wake-up signal with low current and high receiving sensitivity. When the voltage detector detects the wake-up signal, all circuits in the wake-up receiver operate for detecting the wake-up signal with a short wake-up time. The wake-up receiver consumes only 0.3 μA of the power-down current for -32 dBm of the receiving sensitivity with 11 ms of the wake-up time.
DNA Methylation in Anal Intraepithelial Lesions and Anal Squamous Cell Carcinoma

Purpose: Anal intraepithelial neoplasia is associated with human papillomavirus infection and may progress to invasive squamous cell carcinoma (SCC), which is increasing in immunocompromised patients. We hypothesize that anal intraepithelial neoplasia is associated with abnormal DNA methylation and that detection of these events may be used to improve screening programs. Experimental Design: Seventy-six patients were identified who underwent anal cytology screening and subsequent biopsy at our institution between 1999 and 2004. The specimens from these patients included 184 anal biopsies [normal, n = 57; low-grade squamous intraepithelial lesion (LSIL), n = 74; high-grade squamous intraepithelial lesion (HSIL), n = 41; and invasive SCC, n = 12] and 37 residual liquid-based anal cytology specimens (normal, n = 11; LSIL, n = 12; HSIL, n = 14). The methylation status of the following genes was determined for each biopsy and cytology sample using real-time methylation-specific PCR: HIC1, RASSF1, RARB, CDKN2A, p14, TP73, APC, MLH1, MGMT, DAPK1, and IGSF4. Results: Methylation-specific PCR analysis of biopsy samples revealed that DNA methylation was more common in SCC and HSIL than LSIL and normal mucosa. Specifically, methylation of IGSF4 and DAPK1 was prevalent in SCC (75% and 75% of cases, respectively) and HSIL (59% and 71%, respectively) but was absent in LSIL and normal biopsy samples. Methylation profiles of cytologic samples were similar to those found in the biopsy samples. Conclusions: Aberrant DNA methylation is a frequent event in anal HSIL and SCC. Methylation of IGSF4 and DAPK1 is specific for HSIL and SCC, and may serve as a useful molecular biomarker.
Electropalatographic study of speech sound errors in adults with acquired aphasia

Traditionally speech errors in adults with acquired aphasia have been described as either apraxic errors, characteristic of anterior lesions in the cerebral cortex affecting areas such as Broca's area, or phonemic paraphasic errors due to posterior lesions in areas such as Wernicke’s area. However, studies have reported overlap in the descriptions of apraxic and phonemic paraphasic errors despite the assumption that these errors arise from different levels in the speech planning and execution process. For example, phonemic substitutions are associated with both types of error. Part of the problem is due to difficulties in identifying the precise nature and source of the errors which cannot be resolved by auditory perceptual judgements alone. This study investigates, by means of elcctropalatography (EPG), the location and timing of contact patterns produced by ten adults with acquired aphasia. The subjects were variously diagnosed by traditional classification as Broca’s aphasic with or without apraxia, conduction and anomic. These subjects variously demonstrated atypical patterns when compared to ten control speakers such as: increased temporal and/or spatial variability; specific difficulties in the sequencing and timing of two adjacent lingual consonants; and the presence of intrusive lingual/palatal contact patterns. These errors were usually undetected through auditory analysis. The atypical patterns were not associated uniquely with a particular aphasic syndrome but were subject specific and often related to the site of the lesion within the brain, for example, the basal ganglia. Both subjects diagnosed with apraxia of speech and those with phonemic paraphasia produced the EPG patterns noted above. The EPG data provided insights into the nature and origins of errors such as substitutions which were unavailable from auditory-based analysis. Many of these error patterns could be accounted for by modification to Dell’s model of spreading activation (Dell, 1980, 1985, 1986, 1990). The results have important implications for therapeutic intervention since accurate diagnosis is crucial for effective intervention.
Simulations for parallel processing of ultrasound reflection-mode tomography with applications to two-phase flow measurement

An evaluation of the application of a parallel-processing array to the measurement of two-phase flow, such as bubbly oil flow through a pipe, in real-time is described. Pulse-echo ultrasound tomography is used to generate a cross-sectional image of the flow that forms the basis for the deduction of flow parameters, such as the void fraction. The tomographic algorithm used is backprojection adapted for execution on an array of parallel-processing devices. It is shown that real-time reconstruction is feasible using the concepts of parallel processing. Different sensor arrangements were investigated by computer simulation. It is shown that a special multisegment sensor results in a significant improvement in signal-to-noise ratio and image quality and that the reconstructed image benefits from the concurrent activation of multiple receivers per transmitted pulse. The findings may also be useful for nondestructive testing and medical applications. <<ETX>>
Masculinity, Asceticism, Hinduism: Past and Present Imaginings of India

Chandrima Chakraborty, (Ranikhet: Permanent Black, 2011), ISBN 978-8178242989, xi + 263 pp., Rs695, hdbk. Studies of Indian nationalism, whether focussing on contemporary times or the past, have te.
ELABORATION OF THE NRC POPULATION CONSEQUENCES OF ACOUSTIC DISTURBANCE (PCAD) MODEL

The National Research Council has produced four reports on the issue of marine mammals and noise. The first three noted the importance of determining when anthropogenic noise had a significant effect on marine mammals. The most recent report (NRC 2005) focused explicitly on this issue. It recognized that there could be significant effects at three levels: individual, population, and ecosystem. Individual effects become significant when they result in altered reproduction or survivorship of the individual. Population effects become significant when they result in changes in the age-specific fecundity and survivorship characteristics of the population. Finally, ecosystem effects become significant when the survivorship and reproduction of multiple species within the population are affected. The extent to which survivorship and reproduction can change before the results are significant is context dependent. Changes that would be insignificant in normal circumstances can become significant when conditions are bad, e.g., during an El Nino. Changes that would be insignificant in a population near carrying capacity become significant in a depleted population, e.g., North Atlantic right whales. Changes in behaviour that lead to alterations in foraging efficiency, abandonment of habitat, declines in reproduction, and increases in juvenile mortality are difficult to demonstrate in terrestrial animals and are much more difficult for animals that may only rarely be observed in their natural environment. When faced with a difficult problem, the first step is to construct a conceptual model that can serve to bound the problem in the present and suggest lines of additional research for the future.