Miracle-dz/UniFAR-FTUs huggingface dataset:
Worsening of Diet-Induced Atherosclerosis in a New Model of Transgenic Rabbit Expressing the Human Plasma Phospholipid Transfer Protein

Objective—Plasma phospholipid transfer protein (PLTP) is involved in intravascular lipoprotein metabolism. PLTP is known to act through 2 main mechanisms: by remodeling high-density lipoproteins (HDL) and by increasing apolipoprotein (apo) B-containing lipoproteins. The aim of this study was to generate a new model of human PLTP transgenic (HuPLTPTg) rabbit and to determine whether PLTP expression modulates atherosclerosis in this species that, unlike humans and mice, displays naturally very low PLTP activity. Methods and Results—In HuPLTPTg rabbits, the human PLTP cDNA was placed under the control of the human eF1-&agr; gene promoter, resulting in a widespread tissue expression pattern and in increased plasma PLTP. The HuPLTPTg rabbits showed a significant increase in the cholesterol content of the plasma apoB-containing lipoprotein fractions, with a more severe trait when animals were fed a cholesterol-rich diet. In contrast, HDL cholesterol level was not modified in HuPLTPTg rabbits. Formation of aortic fatty streaks was increased in hypercholesterolemic HuPLTPTg animals as compared with nontransgenic littermates. Conclusion—Human PLTP expression in HuPLTPTg rabbit worsens atherosclerosis as a result of increased levels of atherogenic apoB-containing lipoproteins but not of alterations in their antioxidative protection or in cholesterol content of plasma HDL.
Very high Resolution SAR tomography via Compressive Sensing

By using multi-pass SAR acquisitions, SAR tomography (TomoSAR) extends the synthetic aperture principle into the elevation direction for 3-D imaging. Since the orbits of modern space-borne SAR systems, like TerraSAR-X, are tightly controlled, the elevation resolution (depending on the elevation aperture size) is at least an order of magnitude lower than in range and azimuth. Hence, superresolution algorithms are desired. The high anisotropic 3D resolution element renders the signals sparse in elevation. This property suggests using compressive sensing (CS) methods. The paper presents the theory of 4D (i.e. space-time) CS TomoSAR and compares it with classical tomographic methods. Super-resolution properties and point localization accuracies are demonstrated using simulations and real data. A CS reconstruction of a building complex from TerraSAR-X spotlight data is presented. In addition, the model based time warp method for differential tomographic non-linear motion monitoring is proposed and validated by reconstructing seasonal motion (caused by thermal expansion) of a building complex.
Anergy and Cytokine-Mediated Suppression as Distinct Superantigen-Induced Tolerance Mechanisms in Vivo

Recombinant-activating gene 2 (RAG-2−/−) T cell receptor–transgenic mice repeatedly injected with the superantigen staphylococcal enterotoxin A entered a tolerant state in which splenic CD4+ T cells produced little interleukin (IL)-2, interferon γ, or IL-4. This state resulted from a combination of both clonal anergy and cytokine-mediated immunosuppression. The anergy persisted for at least 3 wk and could be distinguished from the suppression by a decrease in IL-2 production per cell, a block in the activation of early response kinases, and a failure to be reversed with anti–transforming growth factor (TGF)-β. Full suppression lasted for only 1 wk and involved both IL-10 and TGF-β, but required additional unknown molecules for optimal effect. These experiments show that complex in vivo interactions of multiple peripheral tolerance mechanisms can now be dissected at both the cellular and molecular levels.
Coupled-clay: Physical-virtual 3D collaborative interaction environment

We propose Coupled-clay, a bi-directional 3D collaborative interactive environment that supports the 3D modeling work between groups of users at remote locations. Coupled-clay consists of two network-connected workspaces, the Physical Interaction Space and the Virtual Interaction Space. The physical interaction space allows a user to directly manipulate a physical object whose shape and position are precisely tracked. This tracked 3D information is transferred to the virtual interaction space in real time. The virtual interaction space is made of an interactive multi-user stereoscopic 3D tabletop, or other 3D displays with adequate interaction device. The users at the virtual interaction space observe the virtual 3D object which corresponds to the physical object and manipulate its geometrical attributes (e.g., translation, rotation and scaling). Additionally, they can control the graphical attributes of the virtual object such as color and texture. Information about changes in geometrical and graphical attributes are sent back to the physical interaction space in real time and reflected to the object in the physical interaction space by a robotic arm and a top-mounted projector. Coupled-clay can be used to remotely collaborate on 3D modeling tasks such as between a skilled designer and novice learners. This paper details our Coupled-clay implementation and presents its interaction capabilities.
Student Leadership Practices of Georgia FFA Success Conference Participants

The purpose of this study was to assess the leadership practices or behaviors of FFA members participating in a leadership development workshop known as the Success Conference in Georgia. Leadership practices were determined using the Student Leadership Practices Inventory (LPI) (Kouzes & Posner, 1998). While success conference participants scored the highest on encouraging the heart (M = 23.77; SD = 4.18) and enabling others to act (M = 23.75; SD = 4.40), placing Georgia FFA members participating in the Success Conference at approximately the 45 th and 35 th percentile respectively for all Student LPI scores, this was slightly below Kouzes’ and Posner’s (1998) normative data for high school students. It is recommended that future leadership development opportunities focus on activities that foster collaboration, strengthen others, recognize the contributions of others, and celebrate team accomplishments.
A research agenda on patient safety in primary care. Recommendations by the LINNEAUS collaboration on patient safety in primary care

ABSTRACT Background: Healthcare can cause avoidable serious harm to patients. Primary care is not an exception, and the relative lack of research in this area lends urgency to a better understanding of patient safety, the future research agenda and the development of primary care oriented safety programmes. Objective: To outline a research agenda for patient safety improvement in primary care in Europe and beyond. Methods: The LINNEAUS collaboration partners analysed existing research on epidemiology and classification of errors, diagnostic and medication errors, safety culture, and learning for and improving patient safety. We discussed ideas for future research in several meetings, workshops and congresses with LINNEAUS collaboration partners, practising GPs, researchers in this field, and policy makers. Results: This paper summarizes and integrates the outcomes of the LINNEAUS collaboration on patient safety in primary care. It proposes a research agenda on improvement strategies for patient safety in primary care. In addition, it provides background information to help to connect research in this field with practicing GPs and other healthcare workers in primary care. Conclusion: Future research studies should target specific primary care domains, using prospective methods and innovative methods such as patient involvement.
On the correlation between route dynamics and routing loops

Routing loops are caused by inconsistencies in the routing state of the network. Although undesirable from this aspect, they can provide insight into the routing dynamics that caused them. In this work we present a methodology that utilizes a priori knowledge of loops to study the correlation between routing loops and routing events that could have caused them. We apply our technique to associate route changes with packet loops detected in actual traffic traces collected from the Sprint Backbone. Our study shows that a strong correlation exists between loops and changes in the BGP routing state while the link state protocols ISIS is seldom responsible for such events. Our analysis also identifies factors that influence the distribution of loop path lengths as well as the effectiveness of our detection techniques.
Signaling via the Angiotensin-Converting Enzyme Enhances the Expression of Cyclooxygenase-2 in Endothelial Cells

Angiotensin-converting enzyme (ACE) inhibitors elicit outside-in signaling via ACE in endothelial cells. This involves the CK2-mediated phosphorylation of ACE on Ser1270 and the activation of the c-Jun N-terminal kinase (JNK)/c-Jun pathway, resulting in an enhanced endothelial ACE expression. Because cyclooxygenase-2 (COX-2) expression is reported to be increased in subjects treated with ACE inhibitors, we determined the role of ACE signaling in this phenomenon and the transcription factors involved. In lungs from mice treated with the ACE inhibitor ramipril for 5 days, COX-2 expression was increased. A similar (1.5- to 2-fold) increase in COX-2 protein was detected in primary cultures of human endothelial cells treated with ramiprilat. In an endothelial cell line stably expressing human somatic ACE, ramiprilat increased COX-2 promoter activity, an effect not observed in ACE-deficient cells or cells expressing a nonphosphorylatable ACE mutant (S1270A). The ramiprilat-induced, ACE-dependent increase in COX-2 expression and promoter activity (both 1.5- to 2-fold greater than control) was prevented by the inhibition of JNK. Ramiprilat significantly enhanced the DNA binding activity of activator protein-1 in cells expressing ACE but not S1270A ACE. Activator protein-1 decoy oligonucleotides prevented the ACE inhibitor-induced increase in COX-2 promoter activity and protein expression. As a consequence of the ramiprilat-induced increase in COX-2 expression, prostacyclin and prostaglandin E2, but not thromboxane A2, production was increased and was inhibited by the COX-2 inhibitor celecoxib. These results indicate that ACE signaling may underlie the increase in COX-2 and prostacyclin levels in patients treated with ACE inhibitors.
Epidemiology, Diagnosis, and Antimicrobial Treatment of Acute Bacterial Meningitis

SUMMARY The epidemiology of bacterial meningitis has changed as a result of the widespread use of conjugate vaccines and preventive antimicrobial treatment of pregnant women. Given the significant morbidity and mortality associated with bacterial meningitis, accurate information is necessary regarding the important etiological agents and populations at risk to ascertain public health measures and ensure appropriate management. In this review, we describe the changing epidemiology of bacterial meningitis in the United States and throughout the world by reviewing the global changes in etiological agents followed by specific microorganism data on the impact of the development and widespread use of conjugate vaccines. We provide recommendations for empirical antimicrobial and adjunctive treatments for clinical subgroups and review available laboratory methods in making the etiological diagnosis of bacterial meningitis. Finally, we summarize risk factors, clinical features, and microbiological diagnostics for the specific bacteria causing this disease.
Innovation in Education Markets: Theory and Evidence on the Impact of Competition and Choice in Charter Schools

Charter schools elevate choice and competition to foster educational innovations. Indeed, these market-style mechanisms are intended to challenge standardized practices associated with district administration of schools. However, a comprehensive review of practices in charter schools indicates that, although some organizational innovations are evident, classroom strategies tend toward the familiar. Drawing on organizational and economic theory, this article considers the forces shaping educational innovation in market-oriented reforms. Although reformers assume that competition and choice necessarily lead to innovations within schools, a more complex examination of competitive institutional environments suggests that mechanisms employed by reformers may actually undercut their intended purposes. The discussion highlights the potential for choice and competition to constrain opportunities for educational innovation and to impose pedagogical and curricular conformity.
The tension between authoritative and dialogic discourse: A fundamental characteristic of meaning making interactions in high school science lessons

In this paper, we draw upon a framework for analyzing the discursive interactions of science classrooms (Mortimer & Scott, 2003, Meaning Making in Secondary Science Classrooms, Maidenhead, UK: Open University Press), to probe the movement between authoritative and dialogic discourse in a Brazilian high school science class. More specifically, we argue the point that such shifts between communicative approaches are an inevitable part of teaching whose purpose is to support meaningful learning of scientific knowledge. We suggest that a necessary tension therefore exists between authoritative and dialogic approaches as dialogic exchanges are followed by authoritative interventions (to develop the canonical scientific view), and the authoritative introduction of new ideas is followed by the opportunity for dialogic application and exploration of those ideas. In these ways, one communicative approach follows from the other, authoritativeness acting as a seed for dialogicity and vice versa. We discuss how this analysis, in terms of shifts in communicative approach, offers a new and complementary perspective on supporting “productive disciplinary engagement” (Engle & Conant, 2002, Cognition and Instruction, 20, 399–484) in the classroom. Finally we consider some methodological issues arising from this study. © 2006 Wiley Periodicals, Inc. Sci Ed90:605–631, 2006
“Stress” and coronary heart disease: psychosocial risk factors

An Expert Working Group of the National Heart Foundation of Australia undertook a review of systematic reviews of the evidence relating to major psychosocial risk factors to assess whether there are independent associations between any of the factors and the development and progression of coronary heart disease (CHD), or the occurrence of acute cardiac events. The expert group concluded that (i) there is strong and consistent evidence of an independent causal association between depression, social isolation and lack of quality social support and the causes and prognosis of CHD; and (ii) there is no strong or consistent evidence for a causal association between chronic life events, work‐related stressors (job control, demands and strain), Type A behaviour patterns, hostility, anxiety disorders or panic disorders and CHD. The increased risk contributed by these psychosocial factors is of similar order to the more conventional CHD risk factors such as smoking, dyslipidaemia and hypertension. The identified psychosocial risk factors should be taken into account during individual CHD risk assessment and management, and have implications for public health policy and research.
Fast and Flexible Movable Vision Measurement for the Surface of a Large-Sized Object

The presented movable vision measurement for the three-dimensional (3D) surface of a large-sized object has the advantages of system simplicity, low cost, and high accuracy. Aiming at addressing the problems of existing movable vision measurement methods, a more suitable method for large-sized products on industrial sites is introduced in this paper. A raster binocular vision sensor and a wide-field camera are combined to form a 3D scanning sensor. During measurement, several planar targets are placed around the object to be measured. With the planar target as an intermediary, the local 3D data measured by the scanning sensor are integrated into the global coordinate system. The effectiveness of the proposed method is verified through physical experiments.
Petty Tyranny in Organizations

A petty tyrant is defined as one who lords his or her power over others. Preliminary empirical work suggests that tyrannical behaviors include arbitrariness and self-aggrandizement, belittling others, lack of consideration, a forcing style of conflict resolution, discouraging initiative, and noncontingent punishment. A model of the antecedents of tyrannical management and the effects of tyranny on subordinates is presented. Petty tyranny is argued to be the product of interactions between individual predispositions (beliefs about the organization, subordinates, and self, and preferences for action) and situational facilitators (institutionalized values and norms, power, and stressors). Tyrannical management is argued to cause low self-esteem, performance, work unit cohesiveness, and leader endorsement, and high frustration, stress, reactance, helplessness, and work alienation among subordinates. It is further argued that these effects may trigger a vicious circle which sustains the tyrannical behavior. Research implications are discussed.
Arrhythmia Evaluation in Wearable ECG Devices

This study evaluates four databases from PhysioNet: The American Heart Association database (AHADB), Creighton University Ventricular Tachyarrhythmia database (CUDB), MIT-BIH Arrhythmia database (MITDB), and MIT-BIH Noise Stress Test database (NSTDB). The ANSI/AAMI EC57:2012 is used for the evaluation of the algorithms for the supraventricular ectopic beat (SVEB), ventricular ectopic beat (VEB), atrial fibrillation (AF), and ventricular fibrillation (VF) via the evaluation of the sensitivity, positive predictivity and false positive rate. Sample entropy, fast Fourier transform (FFT), and multilayer perceptron neural network with backpropagation training algorithm are selected for the integrated detection algorithms. For this study, the result for SVEB has some improvements compared to a previous study that also utilized ANSI/AAMI EC57. In further, VEB sensitivity and positive predictivity gross evaluations have greater than 80%, except for the positive predictivity of the NSTDB database. For AF gross evaluation of MITDB database, the results show very good classification, excluding the episode sensitivity. In advanced, for VF gross evaluation, the episode sensitivity and positive predictivity for the AHADB, MITDB, and CUDB, have greater than 80%, except for MITDB episode positive predictivity, which is 75%. The achieved results show that the proposed integrated SVEB, VEB, AF, and VF detection algorithm has an accurate classification according to ANSI/AAMI EC57:2012. In conclusion, the proposed integrated detection algorithm can achieve good accuracy in comparison with other previous studies. Furthermore, more advanced algorithms and hardware devices should be performed in future for arrhythmia detection and evaluation.
Gene Expression Divergence and Evolutionary Analysis of the Drosomycin Gene Family in Drosophila melanogaster

Drosomycin (Drs) encoding an inducible 44-residue antifungal peptide is clustered with six additional genes, Dro1, Dro2, Dro3, Dro4, Dro5, and Dro6, forming a multigene family on the 3L chromosome arm in Drosophila melanogaster. To get further insight into the regulation of each member of the drosomycin gene family, here we investigated gene expression patterns of this family by either microbe-free injury or microbial challenges using real time RT-PCR. The results indicated that among the seven drosomycin genes, Drs, Dro2, Dro3, Dro4, and Dro5 showed constitutive expressions. Three out of five, Dro2, Dro3, and Dro5, were able to be upregulated by simple injury. Interestingly, Drs is an only gene strongly upregulated when Drosophila was infected with microbes. In contrast to these five genes, Dro1 and Dro6 were not transcribed at all in either noninfected or infected flies. Furthermore, by 5′ rapid amplification of cDNA ends, two transcription start sites were identified in Drs and Dro2, and one in Dro3, Dro4, and Dro5. In addition, NF-κB binding sites were found in promoter regions of Drs, Dro2, Dro3, and Dro5, indicating the importance of NF-κB binding sites for the inducibility of drosomycin genes. Based on the analyses of flanking sequences of each gene in D. melanogaster and phylogenetic relationship of drosomycins in D. melanogaster species-group, we concluded that gene duplications were involved in the formation of the drosomycin gene family. The possible evolutionary fates of drosomycin genes were discussed according to the combining analysis of gene expression pattern, gene structure, and functional divergence of these genes.
The Joint Effects of Neighborhoods, Schools, Peers, and Families on Changes in the School Success of Middle School Students

Longitudinal self-report data from 4,071 students are used to examine the degree to which students’ perceptions of their social environments (people and places) are associated with changes in 3 school success outcomes: school engagement, trouble avoidance, and grades. Specific variable dimensions within the neighborhood, peer, and family domains had significant effects on one or more of these school outcomes. Implications of the findings for further research and intervention practice are discussed, including the availability of a Web-based resource for linking these findings with evidence-based intervention and prevention strategies.
Parameter Selection for Real-Time Controllers in Resource-Constrained Systems

In resource-constrained systems, the interference generated by the concurrent execution of multiple controller tasks leads to extra delay and jitter, which degrade control performance and may even jeopardize the stability of the controlled system. This work presents a general methodology that integrates control issues and real-time schedulability analysis to improve the control performance in embedded systems with time and resource constraints. The performance increase is achieved by properly selecting task periods and deadlines under feasibility constraints.
Learning to Teach for Social Justice.

In this skillfully crafted and engaging book, a group of student teachers - led by Linda Darling-Hammond - share their candid questions, concerns, dilemmas, and lessons learned about how to teach for social justice and social change. This text provides powerful examples of how Darling-Hammond and her students thoughtfully integrated diversity within a teacher education program - an excellent model for educators who are seeking ways to transform their teacher education programs to better prepare teachers to work effectively in multicultural classrooms. The honest reflections, case studies, lessons, and projects described offer valuable tools to help teachers: - Engage in productive dialogues about both the inequities and the possibilities for social reconstruction within the communities where they will be teaching. - Apply the concepts they are learning in a university classroom to teaching for social justice in their own classrooms. - Find ways to use their insights about diversity to intervene on behalf of victimized and marginalized students.