Miracle-dz/UniFAR-FTUs huggingface dataset:
Physiological and production responses to feeding schedule in lactating dairy cows exposed to short-term, moderate heat stress.

The objective of this research was to characterize the production responses of lactating dairy cows during and after short-term, moderate heat exposure, and to determine whether evening (p.m.) feeding would alleviate the associated production losses. In a two-period, cross-over design, eight mature lactating cows were fed a total mixed ration at either 0830 or 2030 h. Each 15-d period consisted of a 5-d thermoneutral phase, a 5-d heat stress phase and a 5-d thermoneutral recovery phase. Mean daily vaginal temperature and respiration rate increased by 0.6 +/- 0.04 degrees C and 27 +/- 1.3 breaths/min, respectively, during short-term heat exposure. Daily dry matter intake, milk yield and solids-not-fat were depressed by 1.4 +/- 0.13 kg, 1.7 +/- 0.32 kg and 0.07 +/- 0.023%, respectively, during heat exposure. During the recovery phase, dry matter intake remained depressed, milk protein declined by 0.05 +/- 0.020%, and daily milk yield exhibited a further decline of 1.2 +/- 0.32 kg. Time of feeding had no effect on vaginal temperature, respiration rate, dry matter intake, water intake, milk yield, fat-corrected milk, protein percent, solids-non-fat percent or somatic cell count during heat exposure or during the recovery period that followed. Fat percent was, however, significantly lower in p.m. -fed animals. These data indicate that short-term, moderate heat stress, which occurs during the spring and summer months in Canada and the Northern United States, will significantly decrease production in the lactating cow. Shifting from morning to evening feeding did not alleviate production losses associated with this type of heat stress.
Abstract Adaptable Videogame Platform for Interactive Upper Extremity Rehabilitation Adaptable Videogame Platform for Interactive Upper Extremity Rehabilitation Adaptive Videogame Platform for Interactive Upper Extremity Rehabilitation

The copyright law of the United States (Title 17, United States Code) governs the making of photocopies or other reproductions of copyrighted material. Under certain conditions specified in the law, libraries and archives are authorized to furnish a photocopy or other reproduction. One of these specified conditions is that the photocopy or reproduction is not to be " used for any purpose other than private study, scholarship, or research. " If a, user makes a request for, or later uses, a photocopy or reproduction for purposes in excess of " fair use " that user may be liable for copyright infringement, This institution reserves the right to refuse to accept a copying order if, in its judgment, fulfillment of the order would involve violation of copyright law. Please Note: The author retains the copyright while the New Jersey Institute of Technology reserves the right to distribute this thesis or dissertation Printing note: If you do not wish to print this page, then select " Pages from: first page # to: last page # " on the print dialog screen The Van Houten library has removed some of the personal information and all signatures from the approval page and biographical sketches of theses and dissertations in order to protect the identity of NJIT graduates and faculty. The primary objective of this work is to design a recreational rehabilitation videogame platform for customizing motivating games that interactively encourage purposeful upper extremity gross motor movements. Virtual reality (VR) technology is a popular application for rehabilitation therapies but there is a constant need for more accessible and affordable systems. We have developed a recreational VR game platform can be used as an independent therapy supplement without laboratory equipment and is inexpensive, motivating, and adaptable. The behaviors and interactive features can be easily modified and customized based on players' limitations or progress. A real-time method of capturing hand movements using programmed color detection mechanisms to create the simulated virtual environments (VET) is implemented. Color markers are tracked and simultaneously given coordinates in the AVE where the player sees representations of their hands and other interacting objects whose behaviors can be customized and adapted to fit therapeutic objectives and players' interests. After gross motor task repetition and involvement in the adaptable games, mobility of the upper extremities may improve. The videogame platform is expanded and optimized to allow modifications to base inputs and algorithms for object …
IL-1 Receptor Accessory Protein-Like 1 Associated with Mental Retardation and Autism Mediates Synapse Formation by Trans-Synaptic Interaction with Protein Tyrosine Phosphatase δ

Mental retardation (MR) and autism are highly heterogeneous neurodevelopmental disorders. IL-1-receptor accessory protein-like 1 (IL1RAPL1) is responsible for nonsyndromic MR and is associated with autism. Thus, the elucidation of the functional role of IL1RAPL1 will contribute to our understanding of the pathogenesis of these mental disorders. Here, we showed that knockdown of endogenous IL1RAPL1 in cultured cortical neurons suppressed the accumulation of punctate staining signals for active zone protein Bassoon and decreased the number of dendritic protrusions. Consistently, the expression of IL1RAPL1 in cultured neurons stimulated the accumulation of Bassoon and spinogenesis. The extracellular domain (ECD) of IL1RAPL1 was required and sufficient for the presynaptic differentiation-inducing activity, while both the ECD and cytoplasmic domain were essential for the spinogenic activity. Notably, the synaptogenic activity of IL1RAPL1 was specific for excitatory synapses. Furthermore, we identified presynaptic protein tyrosine phosphatase (PTP) δ as a major IL1RAPL1–ECD interacting protein by affinity chromatography. IL1RAPL1 interacted selectively with certain forms of PTPδ splice variants carrying mini-exon peptides in Ig-like domains. The synaptogenic activity of IL1RAPL1 was abolished in primary neurons from PTPδ knock-out mice. IL1RAPL1 showed robust synaptogenic activity in vivo when transfected into the cortical neurons of wild-type mice but not in PTPδ knock-out mice. These results suggest that IL1RAPL1 mediates synapse formation through trans-synaptic interaction with PTPδ. Our findings raise an intriguing possibility that the impairment of synapse formation may underlie certain forms of MR and autism as a common pathogenic pathway shared by these mental disorders.
DiscrimNet: Semi-Supervised Action Recognition from Videos using Generative Adversarial Networks

We propose an action recognition framework using Gen- erative Adversarial Networks. Our model involves train- ing a deep convolutional generative adversarial network (DCGAN) using a large video activity dataset without la- bel information. Then we use the trained discriminator from the GAN model as an unsupervised pre-training step and fine-tune the trained discriminator model on a labeled dataset to recognize human activities. We determine good network architectural and hyperparameter settings for us- ing the discriminator from DCGAN as a trained model to learn useful representations for action recognition. Our semi-supervised framework using only appearance infor- mation achieves superior or comparable performance to the current state-of-the-art semi-supervised action recog- nition methods on two challenging video activity datasets: UCF101 and HMDB51.
Design and optimization methodology for 3D RRAM arrays

3D RRAM arrays are studied at the device- and architecture-levels. The memory cell performance for a horizontal cross-point is shown experimentally to be essentially comparable to vertical pillar-around geometry. Array performances (read/write, energy, and speed) of different 3D architectures are investigated by SPICE simulation, showing horizontal stacked RRAM is superior but suffers from higher bit cost. Adopting a bi-layer pillar electrode structure is demonstrated to enlarge the array size in 3D vertical RRAM. Design guidelines are proposed for the 3D VRRAM: it shows that increasing the number of stacks of VRRAM while keeping the total bits the same, as well as scaling of feature size (F), are critical for reducing RC delay and energy consumption.
Operational risk assessment of chemical industries by exploiting accident databases

Accident databases (NRC, RMP, and others) contain records of incidents (e.g., releases and spills) that have occurred in the USA chemical plants during recent years. For various chemical industries, [Kleindorfer, P. R. , Belke, J. C. , Elliott, M. R. , Lee, K. , Lowe, R. A. , & Feldman, H. I. (2003). Accident epidemiology and the US chemical industry: Accident history and worst-case data from RMP*Info. Risk Analysis, 23(5), 865–881. ] summarize the accident frequencies and severities in the RMP*Info database. Also, [Anand, S. , Keren, N. , Tretter, M. J., Wang, Y. , O’Connor, T. M. , & Mannan, M. S. (2006). Harnessing data mining to explore incident databases. Journal of Hazardous Material, 130, 33–41. ] use data mining to analyze the NRC database for Harris County, Texas. Classical statistical approaches are ineffective for low frequency, high consequence events because of their rarity. Given this information limitation, this paper uses Bayesian theory to forecast incident frequencies, their relevant causes, equipment involved, and their consequences, in specific chemical plants. Systematic analyses of the databases also help to avoid future accidents, thereby reducing the risk. More specifically, this paper presents dynamic analyses of incidents in the NRC database. The NRC database is exploited to model the rate of occurrence of incidents in various chemical and petrochemical companies using Bayesian theory. Probability density distributions are formulated for their causes (e.g., equipment failures, operator errors, etc.), and associated equipment items utilized within a particular industry. Bayesian techniques provide posterior estimates of the cause and equipment-failure probabilities. Cross-validation techniques are used for checking the modeling, validation, and prediction accuracies. Differences in the plantand chemical-specific predictions with the overall predictions are demonstrated. Furthermore, extreme value theory is used for consequence modeling of rare events by formulating distributions for events over a threshold value. Finally, the fast-Fourier transform is used to estimate the capital at risk within an industry utilizing the frequency and loss-severity distributions. r 2006 Elsevier Ltd. All rights reserved.
Influence of social media use on discussion network heterogeneity and civic engagement: The moderating role of personality traits

Using original national survey data, we examine how social media use affects individuals' discussion network heterogeneity and their level of civic engagement. We also investigate the moderating role of personality traits (i.e., extraversion and openness to experiences) in this association. Results support the notion that use of social media contributes to heterogeneity of discussion networks and activities in civic life. More importantly, personality traits such as extraversion and openness to experiences were found to moderate the influence of social media on discussion network heterogeneity and civic participation, indicating that the contributing role of social media in increasing network heterogeneity and civic engagement is greater for introverted and less open individuals.
Law and Interdisciplinarity: On the Inevitable Normativity of Legal Studies

The field of legal studies is undergoing rapid changes of a highly diverse nature. Increasing specialization, globalization, the rise of interdisciplinary legal studies, and a growing separation of legal research and teaching prompt the question: What is the aim and method of legal studies? The approach advocated in this article provides a contextual model of legal scholarship. Its most important feature is that the basis for autonomous legal studies lies in the fact that it offers a method of analysis. Legal studies look at the world through the lens of what people ought to do in law. This puts “Law and …” approaches in context: it is impossible to carry out meaningful interdisciplinary work in the law without giving center stage to the question of what the law ought to be. This article explores the consequences of this “inevitable normativity” of legal studies for future academic research and teaching.
Isolated spinal cord contusion in rats induces chronic brain neuroinflammation, neurodegeneration, and cognitive impairment

Cognitive dysfunction has been reported in patients with spinal cord injury (SCI), but it has been questioned whether such changes may reflect concurrent head injury, and the issue has not been addressed mechanistically or in a well-controlled experimental model. Our recent rodent studies examining SCI-induced hyperesthesia revealed neuroinflammatory changes not only in supratentorial pain-regulatory sites, but also in other brain regions, suggesting that additional brain functions may be impacted following SCI. Here we examined effects of isolated thoracic SCI in rats on cognition, brain inflammation, and neurodegeneration. We show for the first time that SCI causes widespread microglial activation in the brain, with increased expression of markers for activated microglia/macrophages, including translocator protein and chemokine ligand 21 (C–C motif). Stereological analysis demonstrated significant neuronal loss in the cortex, thalamus, and hippocampus. SCI caused chronic impairment in spatial, retention, contextual, and fear-related emotional memory—evidenced by poor performance in the Morris water maze, novel objective recognition, and passive avoidance tests. Based on our prior work implicating cell cycle activation (CCA) in chronic neuroinflammation after SCI or traumatic brain injury, we evaluated whether CCA contributed to the observed changes. Increased expression of cell cycle-related genes and proteins was found in hippocampus and cortex after SCI. Posttraumatic brain inflammation, neuronal loss, and cognitive changes were attenuated by systemic post-injury administration of a selective cyclin-dependent kinase inhibitor. These studies demonstrate that chronic brain neurodegeneration occurs after isolated SCI, likely related to sustained microglial activation mediated by cell cycle activation.
Community-based research partnerships: Challenges and opportunities

The complexity of many urban health problems often makes them ill suited to traditional research approaches and interventions. The resultant frustration, together with community calls for genuine partnership in the research process, has highlighted the importance of an alternative paradigm. Community-based participatory research (CBPR) is presented as a promising collaborative approach that combines systematic inquiry, participation, and action to address urban health problems. Following a brief review of its basic tenets and historical roots, key ways in which CBPR adds value to urban health research are introduced and illustrated. Case study examples from diverse international settings are used to illustrate some of the difficult ethical challenges that may arise in the course of CBPR partnership approaches. The concepts of partnership synergy and cultural humility, together with protocols such as Green et al.’s guidelines for appraising CBPR projects, are highlighted as useful tools for urban health researchers seeking to apply this collaborative approach and to deal effectively with the difficult ethical challenges it can present.
Delayed Preconditioning by Sevoflurane Elicits Changes in the Mitochondrial Proteome in Ischemia-Reperfused Rat Hearts

BACKGROUND: Delayed myocardial preconditioning by volatile anesthetics involves changes in DNA transcription and translation. Mitochondria play a central role in myocardial ischemia/reperfusion (I/R) injury and in ischemic or pharmacologic preconditioning. In this study, we investigated whether there are alterations in myocardial mitochondrial protein expression after volatile anesthetic preconditioning (APC) to examine the underlying mechanisms of delayed cardioprotection. METHODS: Thirty-six Sprague-Dawley rats were randomly assigned to 1 of 3 groups (n = 12 for each group). Rats in the delayed APC group were exposed to sevoflurane (2.5% for 60 minutes) 24 hours before myocardial ischemia was induced. Myocardial ischemia in the I/R and APC groups was induced by left coronary artery occlusion for 30 minutes, followed by 120 minutes of reperfusion. The control group received no treatment. The mitochondria fractions were prepared by differential centrifugation with density gradient isolation for proteomic analysis. Two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionization with time-of-flight mass spectrometry was used to identify differences in the protein expression from mitochondria of the rat hearts. RESULTS: Fifteen differentially expressed mitochondrial proteins between the APC group and I/R group were identified and the expression patterns of 2 of the proteins were confirmed by Western blot analysis. These proteins were associated with mitochondrial substrate metabolism, respiration, and adenosine triphosphate (ATP)/adenosine diphosphate transport. The modifications of the mitochondrial proteome suggest an enhanced capacity of mitochondria to maintain myocardial ATP levels after I/R injury. CONCLUSION: Delayed sevoflurane myocardial preconditioning induces mitochondrial proteome remodeling, which mainly involves proteins that are related to ATP generation and transport. Therefore, proteomic changes related to bioenergetic balance may be the mechanistic basis of delayed anesthetic myocardial preconditioning.
A Bibliometric Assessment of Canadian Software Engineering Scholars and Institutions (1996-2006)

This paper summarizes a ranking of Canadian researchers and institutions in the field of software engineering from 1996 to 2006, based on two metrics: impact factors, and h-index. The ranking is going to be an ongoing, annual event to identify the top 50 scholars and top 50 institutions over a 10-year period in Canada. The rankings are calculated based on the impact factor and h-index of papers published in top 12 selected software engineering journals and conferences. The top-ranked institution is Carleton University, and the top-ranked scholars (by each of the two metrics) are Lionel Briand (formerly with Carleton University) and Gail Murphy from UBC.
Promoting products online using firefly algorithm

Opinions on various products are often shared by web users through online social media. These opinions play an important role in decision making criterion for prospective customers. This sharing of experiences works as electronic -word of mouth (e-WOM) publicity for a product in the internet world. The paper presents a distinct e-marketing strategy that takes advantage of attraction mechanism of firefly algorithm along with quick spread behavior of e-WOM for market campaigning. Firefly algorithm is inspired by biochemical and social aspects of real fireflies. The proposed approach analysis the current trend of market in terms of relevant product features. The user interest towards those features is extracted by mining their opinions. Subsequently market segmentation is done by clustering similar users and best segment(s) is selected for product promotion. The strategy finally exploits the social connectedness among online users to identify the best initial seeds. Thus the proposed approach is capable of attracting the attention of a large span of web users by employing a small fraction of advertising budget and has a potential in current e-marketing scenario.
A semantics for advice and dynamic join points in aspect-oriented programming

A characteristic of aspect-oriented programming, as embodied in Aspect J, is the use of advice and point cuts to define behavior that crosscuts the structure of the rest of the code. The events during execution at which advice may execute are called join points. A pointcut is a set of join points. An advice is an action to be taken at the join points in a particular pointcut. In this model of aspect-oriented programming, join points are dynamic in that they refer to events during the flow of execution of the program.We give a denotational semantics for a minilanguage that embodies the key features of dynamic join points, pointcuts, and advice. This is the first semantics for aspect-oriented programming that handles dynamic join points and recursive procedures. It is intended as a baseline semantics against which future correctness results may be measured.
Multiple Cell Transplantation Based on an Intraparenchymal Approach for Patients with Chronic Phase Stroke

Stroke is the third leading cause of death worldwide and a huge perpetrator in adult disability. This pilot clinical study investigates the possible benefits of transplanting multiple cells in chronic stroke. A total of 10 consecutive stroke patients were treated by combination cell transplantation on the basis of an intraparenchymal approach from November 2003 to April 2011. There were six males and four females. Their age ranged from 42 to 87 years, and the course of disease varied from 6 months to 20 years. Six patients suffered cerebral infarction, and four patients suffered a brain hemorrhage. The olfactory ensheathing cells, neural progenitor cells, umbilical cord mesenchymal cells, and Schwann cells were injected through selected routes including intracranial parenchymal implantation, intrathecal implantation, and intravenous administration, respectively. The clinical neurological function was assessed carefully and independently before treatment and during a long-term follow-up using the Clinic Neurologic Impairment Scale and the Barthel index. All patients were followed up successfully from 6 months to 2 years after cell transplantation. Every subject achieved neurological function amelioration including improved speech, muscle strength, muscular tension, balance, pain, and breathing; most patients had an increased Barthel index score and Clinic Neurologic Impairment Scale score. These preliminary results demonstrate the novel strategy of combined multiple cell therapy based on intraparenchymal delivery: it appears to be relatively clinically safe and at least initially beneficial for chronic stroke patients. This manuscript is published as part of the International Association of Neurorestoratology (IANR) supplement issue of Cell Transplantation.