Miracle-dz/UniFAR-FTUs huggingface dataset:
The effects of model upper limb position on observer P300 event-related potential

Summary Study aim: This study reports on the characteristics of learners’ information-gathering processes when receiving visual motor information by examining the influence of differences in model upper limb placement on observer attention. Materials and Methods: The experiment, which was conducted with seven subjects, consisted of a visual oddball task in which subjects were instructed to push a button corresponding to the target image when it was presented on a screen. Two images were used in the task: a “front” image in which the upper limbs were placed in front of the trunk, and an “outside” image in which the upper limbs were placed outside the trunk. The variables measured were brainwaves during task performance, button push reaction time, and questionnaire responses. Brainwaves were recorded at the Fz, Cz, and Pz electrode sites and event-related potentials at the time of target image presentation were calculated. Grand mean waveforms and mean potentials were also compared for the P300. Results: Comparisons of P300 amplification grand mean waveforms and mean potentials revealed that amplification was greater in the front condition than in the outside condition. Conclusion: This finding indicates that differences in model upper limb placement greatly affect observer attention.
Cell Lines Differentiation and Its Prevalent Expression in Schwann-like Homology to S-100 Protein , during Neuroblastoma Cell Inducible Expression of Calcyclin , a Gene with Strong Updated

Calcyclin gene expression was evaluated in different neuroblastoma cell lines and during neuronal differentiation induced by retinole acid. Calcyclin gene expression was more frequently detected in epithelial-type or Schwann-like cells rather than in neuroblastic cells. This result indicates an increase of d cell fraction, which may explain the limited growth potential usually observed for these cells. LAN-5 cell (neuronal type) differentiation experiments showed that calcyclin gene is detectable after 4 days of retinoic acid treatment, which induces (., phase accumu lation (as detected by cytofluorometric analysis), and cell growth arrest. Otherwise, neither block of cell proliferation by 0.5% fetal calf serum medium nor addition of 15% fresh fetal calf serum after cell arrest induce calcyclin expression. The increase of calcyclin mRNA levels during cell differentiation shows that calcyclin gene expression is associated with neuronal differentiation. This bivalent role of the calcyclin gene, which is normally expressed in the G, phase of the cell cycle but also expressed during retinoic acid-induced neuroblastoma cell differentiation, suggests that (at least in neuroblastoma cells) the gene is subject to a complex transcriptional regulation.
Channel-Lining Residues of the AMPA Receptor M2 Segment: Structural Environment of the Q/R Site and Identification of the Selectivity Filter

In AMPA receptor channels, a single amino acid residue (Q/R site) of the M2 segment controls permeation of calcium ions, single-channel conductance, blockade by intracellular polyamines, and permeation of anions. The structural environment of the Q/R site and its positioning with regard to a narrow constriction were probed with the accessibility of substituted cysteines to positively and negatively charged methanethiosulfonate reagents, applied from the extracellular and cytoplasmic sides of the channel. The accessibility patterns confirm that the M2 segment forms a pore loop with the Q/R site positioned at the tip of the loop (position 0) facing the extracellular vestibule. Cytoplasmically accessible residues on the N- and C-terminal sides of position 0 form the ascending α-helical (−8 to −1) and descending random coil (+1 to +6) components of the loop, respectively. Substitution of a glycine residue at position +2 with alanine strongly decreased the permeability of organic cations, indicating that position +2 contributes to the narrow constriction. The anionic 2-sulfonatoethyl-methanethiosufonate reacted with a cysteine at position 0 only from the external side and with cysteines at positions +1 to +4 only from the cytoplasmic side. These results suggest that charge selectivity occurs external to the constriction (+2) and possibly involves interactions of ions with the negative electrostatic potential created by the dipole of the α-helix formed by the ascending limb of the loop.
Association of Overt Diabetes Mellitus with the Non-CC but not the CC Genotype of Interleukin-28B in Hepatitis C Virus Infected Patients

Background: Interleukin-28B (IL-28B) polymorphism is an important predictor for hepatitis C virus (HCV) treatment response. Whether IL-28b genotypes also influence other nontreatment related clinical parameters is unclear. Methods: Patients with HCV-related chronic liver diseases who attended our department during 2012-2014 were retrospectively analyzed. The single nucleotide polymorphisms (SNPs) of rs12979860 (IL-28B) were correlated with various clinical parameters. We also compared these parameters in patients with and without overt diabetes to identify possible associations. Results: A total of 115 patients were included (median age 48, range 15-76 years; 70% males). Overall, 43/115 (37%) patients had chronic hepatitis, while the remaining 72/115 (63%) had cirrhosis. The most common IL-28B genotype was CC, which was found in 53% of patients (61/115), while the remaining 47% were nonCC [CT 42% (48/115) and TT 5% (6/115)]. Clinical and laboratory parameters like Hb, white blood cell (WBC), platelets, bilirubin, transaminases, and albumin were similar in the CC and nonCC genotypes. Overt diabetes mellitus was present in 22% (25/115) of patients. Patients with nonCC genotype had significantly higher prevalence of overt diabetes mellitus than patients with CC genotype (31% [17/54] versus 13% [8/61]; p < 0.05). When parameters were compared in patients with and without overt diabetes mellitus, only IL-28B and age were significantly associated with overt diabetes mellitus (p < 0.05). Conclusion: In HCV patients, overt diabetes mellitus was more commonly associated with the nonCC genotype of IL-28B than the CC genotype. Carriers of the T-allele of SNP rs12979860 were more likely to have insulin resistance than CC homozygotes, and this finding may explain the higher prevalence of diabetes in non-CC genotypes. Thus, an IL-28B test may be useful in patients of HCV in order to determine their likelihood of developing diabetes mellitus.
Constant Darkness Induces IL-6-Dependent Depression-Like Behavior through the NF-κB Signaling Pathway

Substantial experimental evidence indicates a major role for the circadian system in mood disorders. Additionally, proinflammatory cytokines have been proposed to be involved in the pathogenesis of depression. However, the molecular elements determining the functional interplay between these two systems in depression have not been described as yet. Here we investigate whether long-term light deprivation in the constant darkness (DD) paradigm affects depression-like behavior in mice and concomitantly modulates the levels of proinflammatory cytokines. We find that after 4 weeks of DD, mice display depression-like behavior, which is paralleled by reduced hippocampal cell proliferation. This chronobiologically induced depressive state is associated with elevated levels of plasma IL-6 (interleukin-6) and IL-6 and Il1-R1 (interleukin 1 receptor, type I) protein levels in the hippocampus and also alters hippocampal protein levels of the clock genes per2 and npas2. Using pharmacological blockers of the NF-κB pathway, we provide evidence that the effects of DD on depression-like behavior, on hippocampal cell proliferation, on altered expressional levels of brain and plasma IL-6, and on the modulation of clock gene expression are mediated through NF-κB signaling. Moreover, NF-κB activity is enhanced in hippocampal tissue of DD mice. Mice with a deletion of IL-6, one of the target genes of NF-κB, are resistant to DD-induced depression-like behavior, which suggests a pivotal role for this cytokine in the constant darkness mouse model of depression. We here first describe some of the molecular elements bridging chronobiological and inflammatory processes in the constant darkness mouse model of depression.
The effect of age and level of education on intelligibility

Many factors influencing intelligibility have been uncovered in previous research (Bo, 1978; Gooskens, 2006; Jorgensen & Karrlander, 2001). However, in intelligibility research, the effect of age has not been investigated as extensively. Apart from Vanhove’s (2014) investigation of the effect of age on cognate guessing, almost no other studies have paid attention to this factor. Also, in intelligibility research, the effect of educational level on intelligibility is often neglected as most studies only test either pre-university or university students. This paper examines the potential effect of age and level of education on intelligibility. In contrast to Vanhove (2014), we looked at text intelligibility instead of cognate recognition. We tested 2760 Danish participants in a written or spoken cloze test in Dutch, English, German or Swedish, where they had to fill gaps in a text. The participants varied in age and educational background. We found that both age and level of education affect intelligibility scores. However, for the spoken cloze test education did not have a significant effect on intelligibility scores for Dutch and Swedish. Additionally, age had no significant effect on age for Dutch as a test language. For education we found that people with a higher level of education perform better on the test than participants with a lower level of education.
Increased Shedding of Angiotensin-converting Enzyme by a Mutation Identified in the Stalk Region*

Angiotensin-converting enzyme (ACE), an enzyme that plays a major role in vasoactive peptide metabolism, is a type 1 ectoprotein, which is released from the plasma membrane by a proteolytic cleavage occurring in the stalk sequence adjacent to the membrane anchor. In this study, we have discovered the molecular mechanism underlying the marked increase of plasma ACE levels observed in three unrelated individuals. We have identified a Pro1199 → Leu mutation in the juxtamembrane stalk region. In vitro analysis revealed that the shedding of [Leu1199]ACE was enhanced compared with wild-type ACE. The solubilization process of [Leu1199]ACE was stimulated by phorbol esters and inhibited by compound 3, an inhibitor of ACE-secretase. The results of Western blot analysis were consistent with a cleavage at the major described site (Arg1203↓Ser1204). Two-dimensional structural analysis of ACE showed that the mutated residue was critical for the positioning of a specific loop containing the cleavage site. We therefore propose that a local conformational modification caused by the Pro1199 → Leu mutation leads to more accessibility at the stalk region for ACE secretase and is responsible for the enhancement of the cleavage-secretion process. Our results show that different molecular mechanisms are responsible for the common genetic variation of plasma ACE and for its more rare familial elevation.
Appeals to the Hispanic Demographic: Targeting through Facebook Autoplay Videos by the Clinton Campaign during the 2015/2016 Presidential Primaries

By looking at the autoplay videos posted and shared on Hillary Clinton’s Facebook account during the 2015/2016 primary election season, this article offers much needed insight into the communication aspect of campaign targeting. Using data analysis extracted from the leading social media platform, the article examines what groups of Hispanic Facebook users were attracted to Clinton’s targeted autoplay videos, what elements within these videos best enticed these people into liking the videos, and if the Clinton campaign appeared to learn what types of autoplay videos were most effective over the course of the primary season.
Personalized Access, Profile Management, and Context Awareness in Databases in Conjunction with Vldb 2010 Workshop Organization a Benchmark for Context Data Management in Mobile Contextaware Applications Personalization through Query Explanation and Document Adaptation Sql Querie Recommendations: a 

Foreword Proliferation of database-driven web sites has brought upon a plethora of information access and dissemination applications. Monitoring and trading stock portfolios, news notification, weather tracking, and even simple search are just a few examples. In addition, recently, new applications have emerged that go beyond information access and dissemination and enhance creativity, information sharing, and collaboration among users providing richer interaction possibilities. Now, users cannot only access content but they can also generate, share and modify content (both theirs and others') freely, compose their applications, enhance their interface, etc. Web-based communities, wikis, social networks, mashups, folksonomies are some of the emerging new applications. In all these (classical and novel) applications, different notions of user information, such as preferences, community memberships and social interactions, and context information, such as a user's social network, location, time, and other features of a user's environment, are of paramount importance in order to improve and personalize user experience. In this context, new challenges emerge for user-centric, context-aware database systems for storing and managing different aspects of user and context information, for data management and computing taking into account personal, social and contextual information about users and for customizability of their behavior. User-centric, personalized, socially-affected, and context-aware database systems represent a remarkable step towards user-centric applications that allow users to find, generate, share and modify content and services. It is imperative that people studying and working on the different components of a database system clarify their view of contextualization and personalization and describe the ways and degree to which these can be applied to their components of interest. We need a common understanding of the new challenges and we need to design new models, new algorithms, new databases to count for the user-centric requirements of emerging applications. The PersDB 2010 workshop aims at providing a forum for presentation of the latest research results, new technology developments, and new applications in the areas of personalized/socialized access, profile management, and context awareness in database systems. The program committee consisted of 18 members and was chaired by Tiziana Catarci (Universita di Roma "La Sapienza", Italy) and Yannis Stavrakas (Institute for the Management of Information Systems, Greece). We would like to thank all the people who have supported and helped in the organization of this workshop: the authors and presenters of the papers for their interest and participation in PersDB 2010, the reviewers for their time and effort, and the …
Politics and historical imprisonment, 1930–2010

Abstract Theorists have argued that the increasing reliance on imprisonment in the late twentieth and the early twenty-first centuries is associated with a number of important social and political developments that began in the 1960s and 1970s. Despite the emphasis that has been placed on these historically contingent developments, scholars have yet to empirically examine whether the predictive power of recent political variables is restricted to the use of imprisonment in the late twentieth century. The current study addresses this gap in the literature by examining whether four political perspectives are able to account for the use of incarceration at the state level from 1930 to 2010. This study also examines whether the movement from the early to the late twentieth century changed the nature of the relationship between political considerations and jurisdictional reliance on imprisonment. The results indicate that the political party affiliation of elected officials, the public’s commitment to religious fundamentalist sentiment, and the size of African-American populations are significant predictors of imprisonment across the twentieth and early twenty-first centuries.
Enterprise Workload Management through Ant Colony Optimization

Lately, the business enterprise networks (BEN) are expected to support more online applications than what are initially designed for, due to the competitive nature of the business nowadays. The business applications are known to generate sudden increase in traffic workload, which poses challenges in providing guaranteed service to all the new and old clients. Thus, the network administrators are faced with many challenges in how to smartly manage BEN with the available resources and at the same time maintain satisfactory returns on the business. Over-provisioning of resources may not be a feasible solution, and thus, BEN can be improved by re-synthesizing the existing infrastructure by localizing the workflow. At the duration of the sudden increase in the workflow within BEN, we view the infrastructure as a fully connected graph and the aim is to convert the fully connected graph into a connected one by re-grouping the clients into new clusters. We have formulated the conversion problem as an optimization problem with an objective function to maximize the local traffic within the new clusters; moreover, we have utilized Ant Colony Optimization (ACO) to find the suitable conversion. The simulation results show that re-synthesizing a typical BEN comprising of 100 clients with a heavy traffic of 7.54 TB into a set of 5 clusters reduces the backbone traffic by 18%.
A two-tier energy-efficient secure routing protocol for Wireless Sensor Networks

Recently, Wireless Sensor Networks (WSNs) have been deployed into a variety of applications including homeland security, military systems, and health care. Sensor nodes deployed in such networks are subject to several attacks such as sinkhole and select forwarding. Therefore, developing secure and energy-efficient routing protocols to protect WSNs against these attacks while efficiently utilize the energy of the deployed nodes has become imperative. Several routing protocols have been proposed in the literature. However, most of these protocols forward packets based on information collected from neighbor nodes. This allows a malicious sensor node to deceive its neighbor to forward their packets through it. This makes the network's nodes vulnerable to various types of attacks such as sinkhole, spoofing, and select forwarding attacks. Therefore, this paper proposes a two-tier energy-efficient secure routing protocol for WSNs in which each sensor node forwards its packets based on its own information. Thus it cannot be deceived by any other sensor node. Simulation results indicate clearly that, the performance of the proposed protocol outperforms that of both the Path Energy Weight and the minimum hop protocols under several attacks such as sinkhole and spoofing or Sybil attacks. In addition, the proposed protocol exhibits a grateful performance under attack-free conditions and evenly distributes the network loads among the deployed nodes to prolong the network life time.
Analysis of SVM and kNN Classifiers For Egocentric Activity Recognition

Addressing the problem of recognizing egocentric actions is a challenging task. This recognition helps in assisting elderly people, disabled patients and so on. Here, life logging activity videos are taken as input. There are 2 categories, first one is the top level and second one is second level. In this research work, the recognition is done using the features like Histogram of Oriented Gradients (HOG) and Histogram of optical Flow (HOF). The extracted features are provided as input to the classifiers such as Support Vector Machine (SVM) and k Nearest Neighbor (kNN). The performance results showed that SVM gave better results than kNN classifier for both categories.
Chapter 16 OPTIMAL PORTFOLIO APPLICATION WITH DOUBLE-UNIFORM JUMPMODEL

This paper treats jump-diffusion processes in continuous time, with emphasis on the jump-amplitude distributions, developing more appropriate models using parameter estimation for the market in one phase and then applying the resulting model to a stochastic optimal portfolio application in a second phase. The new developments are the use of double-uniform jump-amplitude distributions and time-varying market parameters, introducing more realism into the application model – a lognormal diffusion, log-double-uniform jump-amplitude model. Although unlimited borrowing and short-selling play an important role in pure diffusion models, it is shown that borrowing and shorting is limited for jump-diffusions, but finite jump-amplitude models can allow very large limits in contrast to infinite range models which severely restrict the instant stock fraction to [0,1]. Among all the time-dependent parameters modeled, it appears that the interest and discount rate have the strongest effects.
Structure and function of a nitrifying biofilm as determined by in situ hybridization and the use of microelectrodes

Microprofiles of O2 and NO3- were measured in nitrifying biofilms from the trickling filter of an aquaculture water recirculation system. By use of a newly developed biosensor for NO3-, it was possible to avoid conventional interference from other ions. Nitrification was restricted to a narrow zone of 50 microns on the very top of the film. In the same biofilms, the vertical distributions of members of the lithoautotrophic ammonia-oxidizing genus Nitrosomonas and of the nitrite-oxidizing genus Nitrobacter were investigated by applying fluorescence in situ hybridization of whole fixed cells with 16S rRNA-targeted oligonucleotide probes in combination with confocal laser-scanning microscopy. Ammonia oxidizers formed a dense layer of cell clusters in the upper part of the biofilm, whereas the nitrite oxidizers showed less-dense aggregates in close vicinity to the Nitrosomonas clusters. Both species were not restricted to the oxic zone of the biofilm but were also detected in substantially lower numbers in the anoxic layers and even occasionally at the bottom of the biofilm.
Multi-stack ensemble for job recommendation

This paper describes the approach that team PumpkinPie adopted in the 2016 Recsys Challenge. The task of the competition organized by XING is to predict which job postings the user has interacted with. The team's approach mainly consists in generating a set of models using different techniques, and then combining them in a multi-stack ensemble. This strategy granted the fourth position in the final leader-board to the team, with an overall score of 1.86M.
Rewired retiming for free flip-flop reductions without delay penalty

Due to the intrinsic difference between fan-in and fan-out counts of a retimed component, the number of flip-flops tends to be undesirably increased in a conventional retiming procedure, which can cause a significant area/power penalty on the retimed circuit. Nonetheless, because of the higher dominance on interconnect delays, without a mechanism to reflect real physical design accurately, the clock period produced by a retiming scheme will be unrealistic. To overcome these two major drawbacks of the conventional retiming technique, we propose a novel retiming flow combined with rewiring, being able to largely cut down flip-flops (FFs) while with the original retimed clock period uncompromised. For a more accurate delay estimation, all interconnect delays are formulated and calculated based on real placements. Experimental results show that this novel rewired retiming scheme can bring a reduction of 18.7% (on average) on the number of flip-flops compared to the original retiming without rewiring. This large FF reduction can be considered a free gain as the retimed clock period can still be kept without compromise in such flow. Further experiments have indicated that about 8.26% of the total dynamic power can be saved.