Miracle-dz/UniFAR-FTUs huggingface dataset:
Novel Insights in Systemic Lupus Erythematosus and Atherosclerosis

Introduction The systemic inflammatory nature of systemic lupus erythematosus (SLE) is well patent not only in the diverse clinical manifestations of the disease but also in the increased risk of premature atherosclerosis and cardiovascular events (CVE), making SLE one of the most complex diseases to study and manage in clinical practice. Aim To travel from old aspects to modern insights on the physiopathology, new molecular biomarkers, imaging methods of atherosclerosis assessment, and the potential treatments of atherosclerosis in SLE. Methods We conducted a literature search using PubMed database and performed a critical review. Conclusion/discussion Several developments have taken place in the understanding of the relationship between SLE and premature atherosclerosis. Nevertheless, cardiovascular diseases are still the major cause of reduced life expectancy in SLE and the main cause of death. The lack of standardization methods for the imaging assessment of atherosclerosis in SLE and the multifactorial nature of the disease are well patriated in the difficulty of achieving consistent and reproducible results among studies that focus in cardiovascular risk assessment and prediction. A raising number of molecular biomarkers of atherosclerosis have been proposed, but the combination of several biomarkers and risk factors may better estimate cardiovascular disease risk. Moreover, the development of effective therapies to prevent progression of atherosclerosis and CVE shall address systemic inflammation.
A Power Efficient Technique for Double Layer Massive MIMO Schemes

Next generation of mobile communication systems must support astounding data traffic increases, higher data rates and lower latency, among other requirements. All these requirements should be met while assuring energy efficiency for mobile devices and base stations. Most likely, the future 5G systems will include massive MIMO (Multiple Input Multiple Output) schemes with dozen or hundreds of antennas enabling beamforming while operating in the millimeter wave spectrum. As soon as the millimetric wave propagation difficulties are overcome, the full potential of massive MIMO structures can be tapped. This paper presents a transmission system with bi-dimensional antenna arrays, based on a double layer structure combining beamforming with a multi-branch power amplification that achieves simultaneously power efficiency in amplification of multilevel constellations without penalties on system performance when compared with common schemes using only beamforming.
Once- versus twice-daily aspirin treatment in patients with essential thrombocytosis

Abstract Insufficient platelet inhibition has been reported in up to 40% of aspirin-treated patients, including patients with essential thrombocytosis. To maintain sufficient platelet inhibition, a shorter dosing interval with aspirin has been suggested. We aimed to investigate the antiplatelet effect of low-dose aspirin given twice-daily compared to standard once-daily dosing in patients with essential thrombocytosis. We included 22 patients, who were treated for 7 days with standard once-daily aspirin (75 mg once-daily) followed by 7 days treatment of twice-daily aspirin (37.5 mg twice-daily). The two regimens were separated by 14 days aspirin washout. Blood samples were obtained 1h and 24h/12h after the last pill intake in each regimen. The effect of aspirin was evaluated by: (1) platelet aggregation measured by whole blood impedance aggregometry (Multiplate® Analyser) using arachidonic acid (ASPItest 0.5 mM) as agonist and (2) serum thromboxane B2 levels determined using an enzyme-linked immunosorbent assay. The difference in platelet aggregation from 1h to the end of the dosing interval (24h/12h) was used to compare the two regimens. We demonstrated a significantly smaller difference in platelet aggregation in the twice-daily regimen compared to the once-daily: mean of difference = 228 AU*min (95% confidence interval (CI): 92–363, p < 0.01). In addition, a significantly smaller difference in thromboxane B2 was demonstrated in the twice-daily regimen compared to the once-daily regimen: mean of difference = 16.3 ng/mL (95% CI: 9.9–22.7, p < 0.01). In conclusion, twice-daily dosing with low-dose aspirin provides a more consistent platelet inhibition compared with standard once-daily dosing in patients with essential thrombocytosis.
Characterization of TMR Head Durability against Lapping Based on Magnetic Performance

Magnetic recording technologies are continuing to advance toward higher areal densities, driven by the availability of tunneling magnetoresistive (TMR) heads. However, high areal density heads require smaller physical dimensions, and this can render TMR heads more vulnerable to mechanical stresses generated during the lapping process. Although is important to verify the durability of TMR heads against lapping, it is very difficult to perform a crystallographic analysis of the affected layer because of the small dimensions involved. In this study, we attempted to establish an advanced TMR head verification method based on a magnetic performance analysis involving micro-Kerr hysteresis loops and the magnetic noise spectrum. We found that the magnetic performance changed when nanoscale scratches were removed from the lapped surface using ion beam etching. This indicates that the lapping process produces an affected layer which deteriorates the magnetic characteristics of the TMR head. A correlation was also found between the change in magnetic performance and the morphology of lapped surface.
A Survey: Wireless Sensor Network and its Routing Protocol

Wireless Sensor Network (WSN) is latest technology for sensing and processing different physical and environmental condition data such as heat, temperature, pressure etc.WSN is the network of small sensing node and these node have capability of sensing data and communicating with base station(Sink Node). WSN also have routing capability that route the data to sink node using various routing protocol. WSN routing protocol classified into various types based on network tropology i.e. Flat, Hierarchical and Location Based routing protocol in WSN used for selecting optimal routes path in sensor network. In this paper we study about WSN and different routing protocol that are used in WSN for routes the data to destination node. [2][4]
Moldability of Tackified Fiber Preforms in Liquid Composite Molding

In this work, the effectiveness of using a reactive (bismaleimide) and a non-reactive (polymethylmethacrylate) tackifier in controlling preform springback is investigated using a 6k, 4HS woven graphite fiber mat. Effects of tackifier on preform permeability and fiber wetting are also addressed. Preform springback occurs when the force exerted by the compressed fibers, upon release of an externally applied load, is greater than the "holding" force provided by the tackifier. The latter depends upon the tackifier modulus and the wetted surface area of the preform. The surface area of the pre-form covered by the tackifier can be either interor intralayer, depending upon the rheological properties of the tackifier and the preforming conditions. For the same tackifier concentration, better springback control is achieved when tackifier is inside the fiber tows. Moreover, since mold filling is governed primarily by resin flow between the fiber tows, permeability or flow resistance is not affected much by intra-layer coverage of the tackifier. Blocking of the interstitial gaps within the fiber tows may, however, affect fiber wetting by lowering the capillary pressure.
System-on-a-chip (SoC)-based hardware acceleration for extreme learning machine

Extreme learning machine (ELM) is a popular class of supervised models in machine learning that is used in a wide range of applications, such as image object classification, video content analysis (VCA) and human action recognition. However, ELM classification is a computationally demanding task, and the existing hardware implementations are not efficient for embedded systems. This work addresses the implementation of extreme learning machine (ELM) in a system on a chip field-programmable gate-array (SoC FPGA)-based customized architecture to efficiently utilize hardware accelerator. The optimization process consists of parallelism extraction, algorithm tuning and deep pipelining.
Pediatric mediastinitis as a complication of methicillin-resistant Staphylococcus aureus retropharyngeal abscess.

OBJECTIVE To examine changes in the incidence, bacteriology, and complications of retropharyngeal infection (RPI) over an 8-year period. DESIGN Retrospective medical record review. SETTING Tertiary children's hospital. PATIENTS The study population comprised 108 patients younger than 18 years old. INTERVENTION Medical record review of patients with a discharge diagnosis of RPI (International Classification of Diseases, Ninth Revision code 478.24). MAIN OUTCOME MEASURES Cases from June 1997 to May 2001 were compared with those from June 2001 to May 2005 to examine changes in the incidence, bacteriology, and complications of RPI. RESULTS The number of RPI cases doubled from 36 to 72 in the final 4 years. In the first 4 years, no isolates of methicillin-resistant Staphylococcus aureus (MRSA) were found, and 1 patient developed mediastinitis. In the last 4 years, 8 of 25 patients (32%) with positive cultures had MRSA isolated, and 7 cases of mediastinitis occurred. Of the 8 children with cultures positive for MRSA, 6 developed mediastinitis. The median age for all children with RPI was 32.5 months (n = 108). The median age for children with MRSA and mediastinitis was 6.5 months (n = 8) and 5.5 months (n = 8), respectively. CONCLUSIONS An alarming increase in the number of RPI cases occurred over the final 4 years. Methicillin-resistant S aureus is now a significant pathogen in patients with RPI at our institution. Documented local increases in community-associated MRSA infections and universal sensitivity to clindamycin suggest that community-associated MRSA is responsible for the change in bacteriology. A high correlation exists between MRSA infection and mediastinitis. Patients with MRSA infections are younger and may be vulnerable to developing mediastinitis because of immature immune systems. A higher index of suspicion is needed for MRSA, especially in patients younger than 1 year.
A Study of Pilot Placement Optimization with Constrained MDPs in IEEE802.11p Systems

This paper proposes a decision-assisted pilot placement optimization method in IEEE802.11p physical layer. The fast time-varying channel is first modeled as a typical Gaussian-Markov process. Under the constraint of state-spaces, the pilot optimization problem is further formulated as constrained Markov decision processes (MDPs). Secondly, for achieving compatibility with existing standards, our goal is to determine the optimal pilot placement and employ only very limited pilot patterns in response to fast varying channels. We develop a channel state matched pilot optimization method, where the optimization procedures focus on how to respond the different channel variations in the time and frequency domains. To jointly evaluate the severity of channel variations in the time and frequency domains, we derive an effective mutual information measurement criterion. Simulation and numerical results show the efficiency of the pilot optimization decision scheme in reducing the channel estimation error, and mutual information measurement can yield an accurate performance evaluation in relatively fast time-varying vehicular communication scenarios.
Prediction of creep rupture in unidirectional composite: Creep rupture model with interfacial debonding and its propagation

This paper describes a creep rupture model that takes into account the interfacial debonding and its propagation around broken fibers in unidirectional fiber-reinforced polymers. The interfacial debonding is accompanied by fiber breaks under a longitudinal tensile load, and the interfacial debonding length depends on both the fiber stress at the moment of the fiber breaks and the properties of the interfacial adhesion. In this paper, the interfacial debonding length, its propagation as a function of time, the probability of fiber breaks and an interfacial shear stress are investigated by fragmentation tests with a single glass fiber embedded in each vinylester resin specimen. Subsequently, it was found that a relationship between the fiber strength and the fiber effective length, the length of the debonding length and stress recovery length subtracted from one fiber length, was log linear, and that the larger the fiber stress, the longer was the interfacial debonding length. Next, creep tests were performed to investigate the creep constants of the vinylester resin, and interfacial debonding propagation tests were also performed to identify the interfacial debonding-propagation behavior as a function of time using single fiber composites subjected to constant strains. We modified the creep rupture model by taking into account the interfacial debonding length, which has a time-dependent characteristic, into a conventional Curtin–McLean creep rupture model. It was found that the predicted creep rupture time of the modified model was shorter than that of the conventional model and that there was no threshold creep stress in the modified model unlike in the conventional model because the interfacial debonding propagation makes the prediction creep rupture time lower as time progresses.
Real-time digitized neural-spike storage scheme in multiple channels for biomedical applications

The recording of real time Neural-spikes (N-spikes) into an on-chip memory module is essential for processing the stored information having use in neurological applications like neural spike sorting. Spike sorting is a process used in bio-medical signal processing where incoming real-time spikes are mapped to the neuron from which it originates. In this paper, power and area efficient architectural level storage schemes of digitized N-spikes recorded through multiple channels into a Single Port Random Access Memory (SPRAM) module have been compared. The power dissipation of the proposed storage scheme is in the order of few μW. The architectural level analysis of the schemes has been performed in 0. 18μm CMOS process technology using the Synopsys design compiler tool.
Ductility of a Ti‐6Al‐4V alloy produced by selective laser melting of prealloyed powders

Purpose – The aim of the paper is the study of the change in the mechanical properties (and in particular in ductility), with the microstructure, of a biomedical Ti‐6Al‐4V alloy produced by different variants of selective laser melting (SLM). Design/methodology/approach – Ti‐6Al‐4V alloy produced by different variants of SLM has been mechanically characterized through tensile testing. Its microstructure has been investigated by optical observation after etching and by X‐ray diffraction analysis.Findings – SLM applied to Ti‐6Al‐4V alloy produces a material with a martensitic microstructure. Some microcracks, due the effect of incomplete homologous wetting and residual stresses produced by the large solidification undercooling of the melt pool, are observable in the matrix. Owing to the microstructure, the tensile strength of the additive manufactured parts is higher than the strength of hot worked parts, whereas the ductility is lower. A pre‐heating of the powder bed is effective in assisting remelting and .
Type-indexed rows

Record calculi use labels to distinguish between the elements of products and sums. This paper presents a novel variation, type-indexed rows, in which labels are discarded and elements are indexed by their type alone. The calculus, λTIR, can express tuples, recursive datatypes, monomorphic records, polymorphic extensible records, and closed-world style type-based overloading. Our motivating application of λTIR, however, is to encode the "choice" types of XML, and the "unordered tuple" types of SGML. Indeed, λTIR is the kernel of the language XMλ, a lazy functional language with direct support for XML types ("DTDs") and terms ("documents"). The system is built from rows, equality constraints, insertion constraints and constrained, or qualified, parametric polymorphism. The test for constraint satisfaction is complete, and for constraint entailment is only mildly incomplete. We present a type checking algorithm, and show how λTIR may be implemented by a type-directed translation which replaces type-indexing by conventional natural-number indexing. Though not presented in this paper, we have also developed a constraint simplification algorithm and type inference system.
Ceramic-polytetrafluoroethylene composite material-based miniaturized split-ring patch antenna

Abstract A ceramic-polytetrafluoroethylene high-permittivity dielectric material-based split-ring patch antenna of dimensions 12 mm×16 mm is presented in this paper. The measured operating bandwidths (reflection coefficient <-10 dB) range from 5.0 to 6.5 GHz (1.5 GHz), 9.1 to 9.6 GHz (500 MHz), and 10.7 to 11 GHz (300 MHz) as observed from the proposed antennas. Average gains of 0.69, 3.52, and 3.48 dBi were measured at the first, second, and third band, respectively. Radiation efficiencies of 87.3%, 88.5%, and 93.1% were achieved at three resonant frequencies 5.6, 9.5, and 10.9 GHz, respectively. The measured symmetric and nearly consistent radiation pattern makes the proposed antenna suitable for C band and X band applications. In this paper, the effects of the dielectric properties of substrate material and design parameters have been studied.
Video based reconstruction system for mixed reality environments supporting contextualised non-verbal communication and its study

This Thesis presents a system to capture, reconstruct and render the three-dimensional form of people and objects of interest in such detail that the spatial and visual aspects of non-verbal behaviour can be communicated. The system supports live distribution and simultaneous rendering in multiple locations enabling the apparent teleportation of people and objects. Additionally, the system allows for the recording of live sessions and their playback in natural time with free-viewpoint. It utilises components of a video based reconstruction and a distributed video implementation to create an end-to-end system that can operate in real-time and on commodity hardware. The research addresses the specific challenges of spatial and colour calibration, segmentation and overall system architecture to overcome technical barriers, the requirement of domain specific knowledge to setup and generate avatars to a consistent high quality. Applications of the system include, but are not limited to, telepresence, where the computer generated avatars used in Immersive Collaborative Virtual Environments can be replaced with ones that are faithful of the people they represent and supporting researchers in their study of human communication such as gaze, inter-personal distance and facial expression. The system has been adopted in other research projects and is integrated with a mixed reality application where, during a live linkup, a three-dimensional avatar is streamed to multiple end-points across different countries.
The complete sequence of the mitochondrial genome of Guanling pig (Sus scrofa)

Abstract Guanling pig is one of the native breeds in Guizhou Province in China. The compete mitochondrial genome of Guanling pig was determined by polymerase chain reaction (PCR). The result shows that the compete mitochondrial genome of Guanling pig is 16,731 bp, and it contains a major non-coding control region (D-Loop region), 2 ribosomal RNA genes, 13 protein-coding genes (PCGs) and 22 transfer RNA genes. The mitochondrial DNA control region of the Guanling pig contains repeat motif TAC ACG TGC G, 5′ nucleotide of the first repeat is at the position 814 bp, and the repeat number is 13. The mitochondrial genome of Guanling pig subsequently provides important information in genetic mechanism and the evolution genomes.
Phycosaccharide AI, a mixture of alginate polysaccharides, increases stem cell proliferation in aged keratinocytes

References 1 Grasset N, Gorostidi F et al. Regeneration of epidermis from adult human keratinocytes stem cells. In: Atala A, Lanza R editors. Handbook of Stem Cells. London: Academic Press, 2013: 766– 780. 2 Mavilio F, Pellegrini G, Ferrari S et al. Nat Med 2006: 12: 1397–1402. 3 Tolar J, Xia L, Riddle M J et al. J Invest Dermatol 2011: 131: 848–856. 4 Itoh M, Kiuru M, Cairo MS et al. Proc Natl Acad Sci U S A 2011: 108:8797–8802 5 Tolar J, McGrath J A. Genome Med 2015: 7(1): 15. 6 Guenou H, Nissan X, Larcher F et al. Lancet 2013: 374: 1745–1753. 7 Amabile G, Welner R S, Nombela-Arrieta C et al. Blood 2013: 121: 1255–1264. 8 Suzuki N, Yamazaki S, Yamaguchi T et al. Mol Ther 2013: 21: 1424–1431. 9 Rheinwald J G, Green H. Cell 1975: 6: 317–330.
Optimal Cooperative Strategy in Energy Harvesting Cognitive Radio Networks

We consider a cognitive radio system, in which a secondary transmitter harvests energy from a primary transmitter's wireless signals. If the achievable rate of the primary transmitter's direct link to the primary receiver is smaller than a target rate, the secondary transmitter can provide decode-and-forward relaying service for the primary system and transmit its own data as well, in which the secondary transmitter uses a time-switching protocol to harvest energy and decode primary transmitter's information. Our target is to achieve maximal secondary throughput by selecting the time portion used for energy harvesting and the percentage of the secondary transmitter's power used for relaying. The formulated problem is nonconvex. To solve the problem, we show that, after some math manipulations, the initial problem can be converted to a problem with the objective function being theoretically proved to be quasiconcave. Then we propose a two-level bisection search algorithm to find the maximal objective function. The efficiency of our proposed method is demonstrated by computer simulation.
Ultraviolet and infrared spectral analysis of irradiated polyethylene films : Correlation and possible application for large-dose radiation dosimetry

A detailed study was performed to develop the dosimetric characteristics of commercial low-density polyethylene film (LDPE), which is, by far, the most commonly used plastic for food and for many other-purpose packaging film, to be used as a film dosimeter for large-dose γ-radiation dosimetry. The useful dose range extends up to 880 kGy. Correlations were established between the absorbed dose of γ-radiation and the radiation-induced changes in LDPE measured using Fourier transform infrared (FTIR) and ultraviolet (UV) spectrophotometry. The results showed a significant dependence of the response on the selected readout tool of measurements whether FTIR (at 1716 cm -1 ) or UV ( at 220 and 270 nm) as well as on the quantity used for calculation. The radiation-chemical yield of the ketonic carbonyl group produced in irradiated LDPE film was found to be 0.7 μmol/J. The assessment of the random uncertainty associated with the measurement of the dose response and the effect of relative humidity during irradiation on the dosimeter performance as well as the postirradiation stability at different storage conditions are discussed.