Miracle-dz/UniFAR-FTUs huggingface dataset:
Can Modulation of Mammary Gland Development by Dietary Factors Support Breast Cancer Prevention?

Breast cancer continues to be a major challenge for public health, since it is the most common cancer of women in the Western world, and its prevalence is still increasing. In order to achieve better results in the prevention and treatment of breast cancer it is crucial to identify the mechanisms behind its initiation, i.e. the changes and deviations that have occurred in the mammary gland growth. It has long been known that a woman’s reproductive history is the strongest breast cancer risk factor if genetic background and age are excluded. The reproductive hormones, and the timing of events leading to changes in these hormones, and consequently, in the mammary gland, are the most important players. However, it has become obvious that dietary components may also contribute to breast cancer risk through their effects on the mammary gland. The past few years have added important information to our knowledge of the mechanisms behind breast cancer initiation at the level of target cells (mammary stem cells) and gene expression (genetic ‘fingerprint’ associated with persistent pregnancy-induced protection against breast cancer), as well as of the effects of certain dietary factors (steroid action modulators). These results and their links to breast cancer initiation and progression will be discussed.
White Matter Injury, Neural Connectivity and the Pathophysiology of Psychiatric Disorders

Psychiatric disorders are characterized by diverse clinical manifestations that include deficits in cognition, perception, mood and arousal. These complex processes are not mediated by any specific brain region but require the coordinated activity of several areas that are anatomically connected. Impairments in these neural circuits may therefore be expected to result in an attenuation of the functions regulated by them. The white matter provides the structural and physiological substrate of neural circuits in the central nervous system. We propose that injury to the white matter, from diverse biological sources, may compromise neural connectivity by associated axonal injury or impaired conductivity. Either mechanism could result in clusters of signs and symptoms that are currently recognized as psychiatric disorders. The role of white matter impairment in the pathophysiology of psychiatric illness is under-appreciated in the neurosciences. Focused translational research aimed at identifying the links between white matter compromise and specific behaviors are necessary for a more thorough understanding of the etiology of mental illness to emerge.
DETECTING EMOTION CAUSES WITH A LINGUISTIC RULE‐BASED APPROACH 1

Most theories of emotion treat recognition of a triggering cause event as an integral part of emotion processing. This paper proposes emotion cause detection as a new research area in emotion processing. As a first step toward fully automatic inference of emotion‐cause correlation, we propose a text‐driven, rule‐based approach to emotion cause detection in Chinese. First, we constructed a Chinese emotion cause annotated corpus based on our proposed annotation scheme. Next, we analyzed the corpus data, which yielded the identification of seven groups of linguistic cues and two sets of generalized linguistic rules for the detection of emotion causes. We then developed a rule‐based system for emotion cause detection based on the linguistic rules. In addition, we proposed an evaluation scheme with two phases for performance assessment. The results of our experiments show that our system achieved a promising performance for cause occurrence detection, as well as for cause event detection. The current study should lay the groundwork for future research on the inferences of implicit information and the discovery of new information based on cause‐event relation.
Understanding the heritage tourist market segment

The present paper aims to investigate tourists' perception and brand image associations of heritage destinations as a form of leisure activity. The established behaviour theory [theory of planned behaviour (TPB) (Ajzen, 1991)] was utilised as the key theoretical framework to investigate tourists' perceptions toward participating in heritage tourism activities in Australia and identify brand image associations of heritage destinations. Data collection methods included questionnaire surveys, interviews and focus groups. Sixty-nine respondents participated in the research. Results indicate that tourists were motivated differently when deciding to visit heritage sites. Furthermore, functional, symbolic, experiential associations and overall brand attitudes were identified as key brand image associations toward heritage destinations.
Focusing resources for customer loyalty: An application to the Chilean banking industry

A model is proposed that should enable banking industry executives to better focus resources on loyalty programs by determining which factors are most valued by customers in their decisions to stay with their present bank. The model factors include intangibles drawn from concepts of intellectual capital that influence customers’ perceptions of image, service quality, satisfaction and loyalty. A structural equation model developed for the Chilean banking industry and incorporating eight factors that impact the loyalty of current account customers found that those with the greatest direct effects are satisfaction, image and quality while those with the strongest indirect effects are attention to customers and personalization.
Educational access, equity, and development: planning to make rights realities

The purpose of this monograph, published as part of the Fundamentals of Educational Planning series,1 is to offer insight into the planning of universal access to basic education, understood to mean the completion of a full cycle of primary and lower secondary schooling. Access to education for all children has been a goal of UNESCO since the regional conferences on universal primary education in the early 1960s. It was reflected in the global commitments made at the 1990 Jomtien World Conference on Education for All and at the 2000 Dakar World Education Forum, at which governments made commitments to meet six Education for All goals. Despite considerable progress towards these goals, it is clear that Education for All remains unfinished business. As a result, commitments to universalize access to learning through basic education were renewed at the Global Education for All Meeting in Muscat in 2014. Most recently, the UN Sustainable Development Goals have reasserted the central importance of investment in education for development, and include goals and indicators designed to ensure that every child has their right to education realized (UN Sustainable Development Network, 2015; Lewin, 2015b). By analysing the experience of the past two decades we can identify the main challenges that remain in providing opportunities for all children to learn, and provide a basis for improving planning.
Genetic variation of the human glycine receptor subunit genes GLRA3 and GLRB and susceptibility to idiopathic generalized epilepsies.

Alterations of glycine receptor alpha1 and beta subunit genes have been associated with hypertonic motor disorders in both mice and humans. Mutations in genes encoding other ligand- and voltage-gated ion channels have been identified in rare monogenic forms of idiopathic generalized epilepsies (IGE). We tested the hypothesis that allelic variants of the glycine receptor subunit genes, GLRA3 and GLRB, both localized on chromosome 4q, confer susceptibility to common subtypes of IGE. Mutation screening was carried out in index patients of 14 IGE families. No pathogenic mutation was found, but two intronic polymorphisms were detected in the GLRB gene, and four intronic, three exonic, and one 3'-UTR polymorphisms were identified for the GLRA3 gene. Subsequent screening for exonic and 3'-UTR polymorphisms in GLRA3 showed no statistical difference between a group of sporadic IGE patients (n = 104) and a control group (n = 141). The genotype frequencies for exonic and 3'-UTR polymorphisms in GLRA3 showed no statistically significant difference between IGE patients (n = 104) and an ethnically matched control group (n = 141). Thus, no association between IGE and alterations in GLRA3 or GLRB genes could be detected, indicating that both genes do not play a major causative role in the epileptogenesis of common IGE subtypes. Still, these novel single nucleotide polymorphisms may be useful markers for candidate gene analyses of other disorders.
The use of fatty acid biomarkers to reflect dietary intake

Purpose of review This review compares fatty acid biomarkers to assess compliance in dietary intervention trials with their application in epidemiological studies. Recent findings Although many studies have used fatty acid biomarkers to assess compliance in short-term dietary intervention trials and habitual diets in observational studies, there is little information on the reliability and comparability of these measures. In this review, we summarize the usefulness and limitations of fatty acid biomarkers in clinical and epidemiological studies. As there are very few recent publications in this area, a complete literature review is provided. Summary Several options are available for the biological assessment of dietary fatty acids. The type of study (short or long-term), the metabolic characteristics and expected variability in the fatty acids of interest are major considerations when determining which tissues reflect a better measure of true intake. Certain fatty acids may not be suitable to assess differences in intake under non-isocaloric conditions and when trying to identify small differences. Serum cholesterol ester is the most suitable serum fraction to assess short-term dietary compliance, but given the multiple factors that affect response, the quantification of compliance should be interpreted with caution. Adipose tissue is the biomarker of choice for long-term intake, but a preferred blood constituent (plasma versus erythrocytes) is difficult to establish given the data available to date. Future studies should explore the use of whole blood as an alternative choice to measure fatty acid intake in epidemiological studies.
Corporate ownership characteristics and timeliness of remediation of internal control weaknesses

Purpose - The purpose of the paper is to examine the association between the corporate ownership characteristics and the timely remediation of internal control weaknesses over financial reporting under Section 404 of the Sarbanes-Oxley Act (SOX) of 2002. Design/methodology/approach - The paper employs both ordered and binary logistic regression models for a sample of 695 US firms who reported internal control weaknesses for the first time, pursuant to SOX Section 404, and evaluates the impact of the stock ownership characteristics on the timeliness in remediation of their control weaknesses. Findings - The test results show that the corporate ownership characteristics, as a part of governance mechanism, play an incrementally critical role to influence firms' decisions to promptly remediate their internal control problems and improve the reliability of financial information. In addition, it was also found that a corporate board independent of its CEO is effective in monitoring timely remediation of control problems. Sub-sample analyses for the company-level and account-specific internal control weaknesses produce similar results in support of the effect of corporate stock ownership characteristics on the timely remediation of internal control weaknesses. Originality/value - First, the paper adds to the literature by demonstrating the incremental effect of the stock ownership characteristics on a firm's timeliness in remediation of control weaknesses, even after controlling the effect of audit committee and board characteristics in the analysis. Second, the paper shows that even in the post-SOX years with enhanced regulatory oversight in corporate affairs, the effect of corporate ownership attributes as a part of governance is incrementally observable in a situation that calls for prompt managerial action to ensure the reliability of financial information. Third, for the first time, the study makes a separate detailed analysis on the association between the stock ownership attributes and the remediation of company-level and account-specific control weaknesses. The results provide valuable insights into the ownership governance effect on the remediation of the two types of control weaknesses that have different rigor, auditability (more or less auditable), and effects (pervasive or non-pervasive) on financial reporting quality. Fourth, the study further enhances one's understanding of several important governance factors that help achieve a sound financial reporting system and restore investors' confidence in the system.
Implications of Economic Interdependence for Endogenous Wage Indexation Decisions

This paper shows how economic interdependence affects the indexation decisions of atomistic wage setters in an environment in which monetary authorities do not observe stochastic disturbances before making their policy choices. If stochastic disturbances are common across countries, interdependence has no effect on equilibrium indexation choices in identical countries. However, if disturbances are country specific, numerical simulations show that interdependence is likely to reduce equilibrium indexation choices relative to a small open economy. We also show that indexation choices may be either strategic complements or strategic substitutes, but that strategic complementarity becomes more likely as the degree of interdependence rises. Copyright 1998 by The editors of the Scandinavian Journal of Economics.
Recherche d'Emploi, Contraintes Spatiales et Durée de Chômage

Considering a job search model, this paper investigates what conditions unemployed workers' geographic scope choice for their job search activities and its impact on unemployment duration. The properties of this model are tested by means of duration models econometrics. Econometric tests are carried out on individual transition data drawn from the French TDE survey of the DARES. We conclude to a negative effect of the prospected area enlargement on unemployment duration. The increased job opportunities allowed by such an enlargement seem then to overcome the costs of searching further.
GmDREB2A;2, a Canonical DEHYDRATION-RESPONSIVE ELEMENT-BINDING PROTEIN2-Type Transcription Factor in Soybean, Is Posttranslationally Regulated and Mediates Dehydration-Responsive Element-Dependent Gene Expression1[W][OA]

Soybean (Glycine max) is an important crop around the world. Abiotic stress conditions, such as drought and heat, adversely affect its survival, growth, and production. The DEHYDRATION-RESPONSIVE ELEMENT-BINDING PROTEIN2 (DREB2) group includes transcription factors that contribute to drought and heat stress tolerance by activating transcription through the cis-element dehydration-responsive element (DRE) in response to these stress stimuli. Two modes of regulation, transcriptional and posttranslational, are important for the activation of gene expression by DREB2A in Arabidopsis (Arabidopsis thaliana). However, the regulatory system of DREB2 in soybean is not clear. We identified a new soybean DREB2 gene, GmDREB2A;2, that was highly induced not only by dehydration and heat but also by low temperature. GmDREB2A;2 exhibited a high transactivation activity via DRE and has a serine/threonine-rich region, which corresponds to a negative regulatory domain of DREB2A that is involved in its posttranslational regulation, including destabilization. Despite the partial similarity between these sequences, the activity and stability of the GmDREB2A;2 protein were enhanced by removal of the serine/threonine-rich region in both Arabidopsis and soybean protoplasts, suggestive of a conserved regulatory mechanism that involves the recognition of serine/threonine-rich sequences with a specific pattern. The heterologous expression of GmDREB2A;2 in Arabidopsis induced DRE-regulated stress-inducible genes and improved stress tolerance. However, there were variations in the growth phenotypes of the transgenic Arabidopsis, the induced genes, and their induction ratios between GmDREB2A;2 and DREB2A. Therefore, the basic function and regulatory machinery of DREB2 have been maintained between Arabidopsis and soybean, although differentiation has also occurred.
The ins and outs of lysophosphatidic acid signaling

Lysophosphatidic acid (LPA) is a lipid mediator with a wide variety of biological actions, particularly as an inducer of cell proliferation, migration and survival. LPA binds to specific G‐protein‐coupled receptors and thereby activates multiple signal transduction pathways, including those initiated by the small GTPases Ras, Rho, and Rac. LPA signaling has been implicated in such diverse processes as wound healing, brain development, vascular remodeling and tumor progression. Knowledge of precisely how and where LPA is produced has long proved elusive. Excitingly, it has recently been discovered that LPA is generated from precursors by ‘autotaxin’, a once enigmatic exo‐phosphodiesterase implicated in tumor cell motility. Exogenous phospholipases D can also produce LPA, which may contribute to their toxicity. Here we review recent progress in our understanding of LPA bioactivity, signaling and synthesis. BioEssays 26:870–881, 2004. © 2004 Wiley Periodicals, Inc.
Short-Term Depression of Sprouted Mossy Fiber Synapses from Adult-Born Granule Cells

Epileptic seizures potently modulate hippocampal adult neurogenesis, and adult-born dentate granule cells contribute to the pathologic retrograde sprouting of mossy fiber axons, both hallmarks of temporal lobe epilepsy. The characteristics of these sprouted synapses, however, have been largely unexplored, and the specific contribution of adult-born granule cells to functional mossy fiber sprouting is unknown, primarily due to technical barriers in isolating sprouted mossy fiber synapses for analysis. Here, we used DcxCreERT2 transgenic mice to permanently pulse-label age-defined cohorts of granule cells born either before or after pilocarpine-induced status epilepticus (SE). Using optogenetics, we demonstrate that adult-born granule cells born before SE form functional recurrent monosynaptic excitatory connections with other granule cells. Surprisingly, however, although healthy mossy fiber synapses in CA3 are well characterized “detonator” synapses that potently drive postsynaptic cell firing through their profound frequency-dependent facilitation, sprouted mossy fiber synapses from adult-born cells exhibited profound frequency-dependent depression, despite possessing some of the morphological hallmarks of mossy fiber terminals. Mature granule cells also contributed to functional mossy fiber sprouting, but exhibited less synaptic depression. Interestingly, granule cells born shortly after SE did not form functional excitatory synapses, despite robust sprouting. Our results suggest that, although sprouted mossy fibers form recurrent excitatory circuits with some of the morphological characteristics of typical mossy fiber terminals, the functional characteristics of sprouted synapses would limit the contribution of adult-born granule cells to hippocampal hyperexcitability in the epileptic hippocampus. SIGNIFICANCE STATEMENT In the hippocampal dentate gyrus, seizures drive retrograde sprouting of granule cell mossy fiber axons. We directly activated sprouted mossy fiber synapses from adult-born granule cells to study their synaptic properties. We reveal that sprouted synapses from adult-born granule cells have a diminished ability to sustain recurrent excitation in the epileptic hippocampus, which raises questions about the role of sprouting and adult neurogenesis in sustaining seizure-like activity.
Book Review: Moving Up in the New Economy: Career Ladders for U.S. Workers

been identified before publication. For example, on pages 67-68 reference is made in the narrative to data in “Table 1” (actually labeled “Table 4.1”) about the industries and occupations where participants in the New Jersey project were employed. There are no such data presented in the table. Another example includes the Personal Responsibility and Work Opportunity and Reconciliation Act of 1996 being frequently referred to as “PROWA” (the correct acronym is PRWORA). Although readers familiar with the vernacular of welfare reform would likely be able to determine what the authors are referring to, these and numerous other mistakes related to spelling and grammar are substantial distractions and detract from the book’s overall quality. Mary L. Gatta and Kevin P. McCabe are to be applauded for highlighting the challenges of implementing workforce development programs and for reporting on their activities related to the New Jersey online learning program. A detailed description of the program and its evaluation, and more careful editing, would have enhanced the impact of their book.
Decentralized Active and Reactive Power Control for an AC-Stacked PV Inverter With Single Member Phase Compensation

This paper proposes a decentralized control scheme for controlling active and reactive power of grid-tied ac-stacked photovoltaic (PV) inverter architecture using single member phase compensation. Reactive power control is required for the next generation of grid-tied smart PV inverter systems in power networks with high PV penetration. The decentralized control scheme proposed in this paper allows for a fully distributed architecture, both in terms of active and reactive power control and physical implementation of a PV system. This will result in higher reliability and potentially lower cost with minimum communications requirements. A decentralized controller enables higher switching frequencies that can shrink passive components. Therefore, string voltage variations due to voltage drop across passive components will be negligible and the system will be controlled with minimum communications requirement. The relative gain array approach has been used to study the feasibility of the decentralized control scheme. Detailed modeling and analysis are provided to show the effectiveness of the proposed decentralized approach and the effect of this approach on control implementation. Finally, effectiveness of the proposed decentralized approach is verified using mathematical modeling, simulation, and a lab-scale experimental setup in different operation conditions.
PFC converter based power quality improvement and ripple current minimization in BLDC motor drive

This manuscript deals about the configuration of a power factor correction (PFC) converter feeding a drive of brushless DC (BLDC) motor for medium and low power equipment. The front-end PFC converter working in discontinuous inductor current mode (DICM) is applied for regulating the DC link voltage and PFC is achieved inherently. The BLDC motor speed is adjusted by regulating the DC link voltage of voltage source inverter (VSI) feeding to motor. The DC link voltage of drive system is maintained by a single DC voltage actuator. A prototype is developed for evaluating the performances of anticipated drive for the speed control over a broad range. The performance of anticipated drive is also validated for its function at varying AC mains voltages (90V-265V). Test results for power quality (PQ) parameters are compared with restrictions of power quality standard IEC 61000-3-2.