Miracle-dz/UniFAR-FTUs huggingface dataset:
Title Functional Roles of Multiple Feedback Loops in Extracellular Signal-Regulated Kinase and Wnt Signaling Pathways That Regulate Epithelial-Mesenchymal Transition

The UCD community has made this article openly available. Please share how this access benefits you. Your story matters! (@ucd_oa) Some rights reserved. For more information, please see the item record link above. ABSTRACT Epithelial-mesenchymal transition (EMT) is a key event in the generation of invasive tumor cells. A hallmark of EMT is the repression of E-cadherin expression, which is regulated by various signal transduction pathways including extracellular signal regulated-kinase (ERK) and Wnt. These pathways are highly interconnected via multiple coupled feedback loops (CFLs). As the function of such coupled feedback regulations are difficult to analyze experimentally, we used a systems biology approach where computational models were designed to predict biological effects that result from the complex interplay of coupled feedback loops. Using EGF and Wnt as input and E-cadherin transcriptional regulation as output we established an ordinary differential equation (ODE) model of the ERK and Wnt signaling network containing six feedback links and used extensive computer simulations to analyze the effects of these feedback links in isolation and different combinations. The results show that the feedbacks can generate a rich dynamic behavior leading to various dose response patterns and have a decisive role in determining network responses to EGF and Wnt. In particular, we made two important findings. First, that coupled positive feedback loops (CPFLs) composed of phosphorylation of Raf kinase inhibitor RKIP by ERK and transcriptional repression of RKIP by Snail have an essential role in causing a switch-like behavior of E-cadherin expression. Second, that RKIP expression inhibits EMT progression by preventing E-cadherin suppression. Taken together, our findings provide us with a system-level understanding on how RKIP can regulate EMT progression and may explain why RKIP is down-regulated in so many metastatic cancer cells.
Relation of Dental Anomalies with Occlusal Alterations in the Pediatric Patients

Objective: To identify the dental anomalies that can modify the occlusal characteristics and their distribution in these occlusal alterations in the skeletal patterns of children. Material and Methods: We analyzed charts, panoramic and periapical radiographs of children aged 5 to 12 years from 2009 to 2012. The facial pattern was evaluated through subjective face analysis and cephalometric data, as well as the occlusion of patients with and without (control) dental anomalies. The relationship between the presence of dental anomalies and malocclusion was analyzed by the Chi-square test with significance level of 5%. Results: 73 children (27.8%) presented dental anomalies, being 49.3% in girls and 50.7% in boys in a total of 88 teeth involved. Anomalies observed in decreasing order were: enamel hypoplasias, eruptive ectopias, agenesis, supernumerary teeth, corono-radicular dilaceration, microdontia, transposition and imperfect amelogenesis. Of these, 22.2% presented associated dental anomalies, whose ectopic eruption with enamel hypoplasia were the most frequently encountered. When comparing the control group with children with dental abnormalities it was observed a significant relationship between the presence of dental anomalies and malocclusion (p<0.05). The most frequent alteration among patients with dental anomalies was deep overbite (24.6%), followed by crowding (23.3%), posterior crossbite (14.2%), anterior open bite (12.9%) and anterior crossbite (0.3%). Conclusion: Dental dysgenesis interferes with the development of occlusion and the resulting occlusal problems are distributed differently, taking into account the skeletal facial pattern in patients with and without dental anomalies.
Coretic : nouvelle écriture des règles pour améliorer l'isolation et la composition en SDN

SDN (Software Defined Networking) est une nouvelle architecture reseau qui permet d’apporter une solution a la complexite des tâches des equipements reseaux. Cette architecture permet de separer le plan de donnees, charge d’acheminer les donnees, du plan de controle qui fournit les regles de gestion des flux. Au-dessus du plan de controle, s’ajoute le plan de gestion qui permet d’envoyer des instructions au plan de donnees en utilisant un langage evolue. Les travaux de recherche apportent des solutions pour permettre l’isolation des trafics, la composition des plans de controle et pour la gestion des flux au niveau du plan de gestion en SDN. Les solutions actuelles d’isolation et de composition presentent des techniques de gestion des entrees de flux ayant des faiblesses. Certaines utilisent des informations de la couche 2 du modele OSI (Open System Interconnection) (Ahmed, Mohamed Fekih. 2015). Effectuer l’isolation en se servant des informations de la couche 2 entraine une generation de plusieurs entrees dans les tables de flux, ce qui affecte les performances. D’autres solutions utilisent une seule table de flux pour inserer les regles de plusieurs controleurs (Jin, Xin. 2015). Ceci entraine une cohesion faible des tables concernees. Un couplage eleve est aussi constate par l’utilisation de plusieurs tables reliees entre elles (Dixit, A. 2014). Quant aux solutions au niveau du plan de gestion, elles ne permettent pas a plusieurs plateformes de programmation de haut niveau d’utiliser un controleur commun. Dans ce travail de maitrise, il est propose Coretic qui vise a ameliorer l’ecriture des regles dans le plan de donnees pour l’isolation et la composition. Etant donne que le role du plan de controle est confie au plan de gestion utilisant les plateformes de programmation de haut niveau, ce travail propose une solution permettant d’isoler le trafic des plans de gestion en utilisant un controleur commun. Coretic pour atteindre ses objectifs se sert des informations de la couche 3 du modele OSI et de plusieurs tables de flux. Des tests de performance ont permis de montrer que Coretic offre de meilleures performances dans l’isolation et la composition. La solution d’hypervision des plans de gestions ne cree pas une degradation importante des performances. Coretic a la suite des tests effectues apporte les contributions suivantes : • Apport d’une nouvelle approche d’isolation et de composition de plans de controles basee sur l’utilisation de tables multiples et de l’utilisation d’adresses IP de la couche 3. • Apport d’une solution d’hypervision des plans de gestion. Ces contributions permettent d’ameliorer les performances dans le plan de donnees. La cohesion des tables de flux est renforcee, car ces tables recoivent chacune des politiques bien precises. Le couplage devient faible aussi, car Coretic laisse les tables traiter les flux en toute independance. Avec Coretic, il est possible d’utiliser qu’un seul controleur pour isoler le traffic de plusieurs plans de gestion.
Agent-based system for sales order tracking with RFID technology

Toward household electric appliance (HEA) enterprises sales order lifecycle is proposed. In order to access to real time sales information at retailers, efficient mobile agent-based sales order tracking (MASOT) system architecture is constructed with RFID technology, based on the sales order lifecycle. In MASOT system, RFID technology is implemented at retailers, which collects accurate data and provides bases for tracking agent. SVM method is used to evaluate the performances of retailers based on achieved data by mobile agent. In order to occupy less tag storage capacity, a virtual data environment based XML format is presented. A sales orders tracking processing algorithm is proposed based on dynamic tracking cycle which is adjusted by retrieved data. Finally, a phototype system is presented.
Automatic design and manufacture of robotic lifeforms

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Analysis of Various Features using Different Temporal Derivatives from Speech Signals

Speech recognition being an upcoming field is evaluated and research is being done for the same. Research in speech recognition for different languages is at peak. Less amount of work has been done for Indian languages particularly for Punjabi language. In this paper, Punjabi speech has been analyzed by extracting various features along with different temporal derivatives using feature extraction techniques. The dataset which has been considered for the research work is the set of Punjabi isolated digit recorded as 24 bit 44100 Hz mono PCM signal. Comparison of range and accuracy for acceptable results has been determined using HMM.
Effectiveness of a novel feature and confidence levels assignment to classifiers in fingerprint matching

There are different methods and techniques used for matching fingerprints but the most common and popular approach is minutiae based matching. Our approach is based on structural matching and the matching algorithm presented here is the improved and modified form of [1]. In this method, matching is done on the basis of five closest neighbors of one single minutia that is also called a center minutia. An authentication of minutia is based on these surrounding neighbors. The approach we present here is divided in to two stages, first stage performs initial filtration and the second stage includes special matching criteria that incorporate fuzzy logic as well as a novel feature to select final minutiae for matching score calculation. The method of selecting center point for second stage is also adopted. This algorithm is able to perform well for translated, rotated and stretched fingerprints and does not require any process for alignment before matching. Experimental results show that algorithm is efficient and reliable.
Improving Students’ Reading Comprehension through Cooperative Learning Strategies Using Numbered Heads Together

This research aimed at improving students reading comprehension through cooperative learning strategies using numbered heads together in MTs Ma’arif 2 Muntilan. This was classroom action research with 3 cycles. There were 4 steps in conducting the research; (1) Planning; (2) Acting; (3) Observing; (4) Reflecting. This research involved 27 students of eight graders. The instruments used in this research were observation, interview, test (pre-test and post- test), field-notes, questionnaire, and documentation. It was found that the students’ average score in pre-test was 46, the first post-test was 59. The second post-test was 81 and the third post-test was 94. It meant that the post-test was higher than pre-test. Besides, the students also had been well interested during the learning process in each cycle. In conclusion, the findings of this research showed that through CL strategies using NHT could improve the students’ reading comprehension. Hence, it is recommended for the further researcher to use NHT as an alternative strategy in improving the students’ reading comprehension.
Identity-Based Secret Signature Scheme

Secret signature, proposed by Lee et al. [11], is a new signature scheme which provides signature privacy and public provability together. Using the secret signature scheme a signer can send his signature secretly to a specific receiver such that only the designated receiver can verify the signature. If any argument occurs between them, the validity of the secret signature can be proven publicly either by the signer or the receiver. Thus it can be used as an important cryptographic primitive to implement private business transactions. In this paper we present an identity-based implementation of secret signature scheme which can enjoy the advantage of reducing key management load compared with the traditional certificate-based cryptography. We modify Cha-Cheon’s IDbased signature scheme [3] and ID-based key agreement scheme [14] to provide public provability, and then combine them to implement ID-based secret signature (IBSS) scheme.
Use of computer assistive technologies by older people with sight impairment: Perceived state of access and considerations for adoption

This study explored the perceptions of sight-impaired older people about the use of specialist equipment designed for computer users with sight loss – whether it was meeting their needs and their views on the opportunities for equality in access to computer technologies. The study employed case study research methodology: conducting observations in an Internet café specifically established for people with sight loss and semi-structured interviews with 20 participants who had sight impairments between the ages of 60 and 87 years. A thematic analysis was carried out on transcribed qualitative interview data. Qualitative analysis employed the use of NVivo version 10 for both open and axial coding. Related coded categories were eventually merged into four themes. Findings suggest that stereotyping associated with the use of assistive technologies such as screen readers and concerns about access to mainstream technologies are important factors for understanding acceptance, willingness to adopt assistive technology, or continued use of assistive technologies by sight-impaired older people. Participants perceived advancements in technology as not fully considering their needs. In conclusion, the study highlights important points for technology developers to consider for inclusive designs or cost-effective assistive technologies as social stigma remains a neglected construct for understanding acceptance, willingness to adopt assistive technology, or continued use of assistive technologies among sight-imapired older people.
Fault-tolerant 3D clock network

Clock tree synthesis is one of the most important and challenging problems in 3D ICs. The clock signals have to be delivered by through-silicon vias (TSVs) to different tiers with minimum skew and latency. While there are a few related works in literature, none of them considers the reliability of TSVs. Accordingly, the failure of any TSV in the clock tree yields a bad chip. The naive solution using double-TSV can alleviate the problem. But the significant area overhead renders it less practical for large designs. In this paper, we propose a novel TSV fault-tolerant unit (TFU) that can provide tolerance against TSV failures in a 3D clock network. It makes use of the existing 2D redundant trees designed for pre-bond testing, and thus has minimum area overhead. Compared to the double TSV technique, the 3D clock network constructed by our TFUs can achieve 61% area reduction with 3.9% yield rate improvement on an industrial case. To the best of the authors' knowledge, this is the first practical work in literature that considers the fault tolerance of a 3D clock network.
Study protocol for a pragmatic randomised controlled trial evaluating efficacy of a smoking cessation e-‘Tabac Info Service’: ee-TIS trial

Introduction A French national smoking cessation service, Tabac Info Service, has been developed to provide an adapted quitline and a web and mobile application involving personalised contacts (eg, questionnaires, advice, activities, messages) to support smoking cessation. This paper presents the study protocol of the evaluation of the application (e-intervention Tabac Info Service (e-TIS)). The primary objective is to assess the efficacy of e-TIS. The secondary objectives are to (1) describe efficacy variations with regard to users' characteristics, (2) analyse mechanisms and contextual conditions of e-TIS efficacy. Methods and analyses The study design is a two-arm pragmatic randomised controlled trial including a process evaluation with at least 3000 participants randomised to the intervention or to the control arm (current practices). Inclusion criteria are: aged 18 years or over, current smoker, having completed the online consent forms, possessing a mobile phone with android or apple systems and using mobile applications, wanting to stop smoking sooner or later. The primary outcome is the point prevalence abstinence of 7 days at 6 months later. Data will be analysed in intention to treat (primary) and per protocol analyses. A logistic regression will be carried out to estimate an OR (95% CI) for efficacy. A multivariate multilevel analysis will explore the influence on results of patients' characteristics (sex, age, education and socioprofessional levels, dependency, motivation, quit experiences) and contextual factors, conditions of use, behaviour change techniques. Ethics and dissemination The study protocol was reviewed by the ethical and deontological institutional review board of the French Institute for Public Health Surveillance on 18 April 2016. The findings of this study will allow us to characterise the efficacy of e-TIS and conditions of its efficacy. These findings will be disseminated through peer-reviewed articles. Trial registration number NCT02841683; Pre-results.
Anthropogenic N Deposition Slows Decay by Favoring Bacterial Metabolism: Insights from Metagenomic Analyses

Litter decomposition is an enzymatically-complex process that is mediated by a diverse assemblage of saprophytic microorganisms. It is a globally important biogeochemical process that can be suppressed by anthropogenic N deposition. In a northern hardwood forest ecosystem located in Michigan, USA, 20 years of experimentally increased atmospheric N deposition has reduced forest floor decay and increased soil C storage. Here, we paired extracellular enzyme assays with shotgun metagenomics to assess if anthropogenic N deposition has altered the functional potential of microbial communities inhabiting decaying forest floor. Experimental N deposition significantly reduced the activity of extracellular enzymes mediating plant cell wall decay, which occurred concurrently with changes in the relative abundance of metagenomic functional gene pathways mediating the metabolism of carbohydrates, aromatic compounds, as well as microbial respiration. Moreover, experimental N deposition increased the relative abundance of 50 of the 60 gene pathways, the majority of which were associated with saprotrophic bacteria. Conversely, the relative abundance and composition of fungal genes mediating the metabolism of plant litter was not affected by experimental N deposition. Future rates of atmospheric N deposition have favored saprotrophic soil bacteria, whereas the metabolic potential of saprotrophic fungi appears resilient to this agent of environmental change. Results presented here provide evidence that changes in the functional capacity of saprotrophic soil microorganisms mediate how anthropogenic N deposition increases C storage in soil.
An EMFi-film sensor based ballistocardiographic chair: performance and cycle extraction method

New sensor technologies open possibilities for measuring traditional biosignals in new innovative ways. This, together with the development of signal processing systems and their computing power, can sometimes give new life to old measurement techniques. Ballistocardiogram is one such technique, originally promising but quickly replaced by the now very popular electrocardiogram. A ballistocardiograph chair, designed to look like a normal office chair, was built and fitted with pressure sensitive EMFi-films. The films are connected via a charge amplifier to a medical bioamplifier. The system was accepted for medical use in Tampere University Hospital and patient measurements have been performed. The system is presented and it's performance evaluated. A wireless version of the system is needed to hide the cabling from the user. This makes the chair indistinguishable from a normal office chair. Overview of first wireless prototype is given. To analyze recorded BCG, individual BCG cycles must be extracted from the signal containing respiration and movement artifacts. A method for this and results of it's application are presented. The developed system can be used for BCG measurements and it is able to automatically extract individual BCG cycles, but it has some limitations which are presented in the paper.
Complexity Comparison of Iterative Channel Estimation , Equalization and Decoding for GSM Receivers

A. INTRODUCTION Intersymbol Interference (ISI) caused by multi-path propagation is a significant problem in digital mobile communication system. In addition, the channel characteristic is time varying due to the movement of the mobile station relative to its surrounding. In a time division multiplex access (TDMA) system like GSM, the receiver must be able to estimate the channel and compensate for channel distortion adaptively. The performance of this compensation is largely determined by the accuracy of the channel estimation. In a conventional GSM receiver, the channel impulse response (CIR) is estimated using the known training sequence transmitted as a midamble in each burst. Feeding back the estimated data output from the equalizer or decoder as an extended training sequence can improve the accuracy of the estimated CIR. Which is called iterative channel estimation (ICE) [1]. The channel encoder and ISI channel can be treated as a serially concatenated coding scheme, the decoding principle of Turbo Code [2] can be used to perform iterative equalization and decoding [3]. Four different types of GSM receiver with these techniques were introduced. The complexity of implemented these receivers and the corresponding performances are compared here in terms of number of operations required in receiving one GSM block. This paper is organized as follows: in section 2, we introduce the configuration of four candidate GSM receivers employing various iterative schemes. Their complexity analysis is presented in section 3. Simulation results of bit error rate (BER) performance are presented in section 4, and the conclusion is made in section 5. B. CANDIDATE GSM RECEIVERS The typical structure of the GSM digital receiver is shown in Figure 1. The channel impulse response (CIR) is estimated by a known training sequence or data sequence transmitted as a midamble in each GSM burst. The channel is estimated using channel sounding (CS) [4] or least square (LS) [5] techniques, and this estimated CIR is used in equalization process to eliminate the impact of Intersymbol Interference (ISI). After de-interleaving, the decoder estimates the original message sequence. In this paper, we consider receivers which employ maximum a posteriori probability (MAP) [6] algorithm for equalization and either maximum likelihood sequence estimation (MLSE) [7] or MAP estimation in the decoder. The MAP algorithm is a soft-in soft-out (SISO) algorithm, which is well suited to iterative receiver schemes. In conventional training sequence receiver, the channel impulse response was estimated by the known training sequence stored at …
Development of Honeypot System Emulating Functions of Database Server

Abstract : Possibilities to develop the honeypot type intrusion detection systems (IDS) for databases are discussed. Two types of concept honeypot systems are suggested. Network level system is based on the emulation of the database connections and is aimed to detect intruders searching for database servers and attempting to read basic database listeners information. Honeypot type database level IDS module is aimed to react to enquiries of database tables not used by real applications but loaded to the database to attract intruders.