Miracle-dz/UniFAR-FTUs huggingface dataset:
Calcitriol exerts an anti‐tumor effect in osteosarcoma by inducing the endoplasmic reticulum stress response

Osteosarcoma is the most common type of primary bone tumor, and novel therapeutic approaches for this disease are urgently required. To identify effective agents, we screened a panel of Food and Drug Administration (FDA)‐approved drugs in AXT cells, our newly established mouse osteosarcoma line, and identified calcitriol as a candidate compound with therapeutic efficacy for this disease. Calcitriol inhibited cell proliferation in AXT cells by blocking cell cycle progression. From a mechanistic standpoint, calcitriol induced endoplasmic reticulum (ER) stress, which was potentially responsible for downregulation of cyclin D1, activation of p38 MAPK, and intracellular production of reactive oxygen species (ROS). Knockdown of Atf4 or Ddit3 restored cell viability after calcitriol treatment, indicating that the ER stress response was indeed responsible for the anti‐proliferative effect in AXT cells. Notably, the ER stress response was induced to a lesser extent in human osteosarcoma than in AXT cells, consistent with the weaker suppressive effect on cell growth in the human cells. Thus, the magnitude of ER stress induced by calcitriol might be an index of its anti‐osteosarcoma effect. Although mice treated with calcitriol exhibited weight loss and elevated serum calcium levels, a single dose was sufficient to decrease osteosarcoma tumor size in vivo. Our findings suggest that calcitriol holds therapeutic potential for treatment of osteosarcoma, assuming that techniques to diminish its toxicity could be established. In addition, our results show that calcitriol could still be safely administered to osteosarcoma patients for its original purposes, including treatment of osteoporosis.
Review on powder-bed laser additive manufacturing of Inconel 718 parts

This study presents a thorough literature review on the powder-bed laser additive manufacturing processes such as selective laser melting of Inconel 718 parts. This article first introduces the general aspects of powder-bed laser additive manufacturing and then discusses the unique characteristics and advantages of selective laser melting. The bulk of this study includes extensive discussions of microstructures and mechanical properties, together with the application ranges of Inconel 718 parts fabricated by selective laser melting.
Surface plasmon resonance in gold nanoparticles

Gold thin film of 1,3,6&10nm thickness was deposited on the glass slide and absorption spectra were measured in UV-Vis range. It has been observed that as the thickness of the gold film increases the absorption peak shifts towards the higher wavelength side. Also, thickness of gold film introduces the morphological change in these nanoparticles. Nanoparticles became more elliptical as the thickness of the film increases which was observed as the increase in the separation of peaks associated with longitudinal and transverse mode in the absorption spectra.
Fibers Obtaining and Characterization Using Poly (Lactic-co-Glycolic Acid) and Poly (Isoprene) Containing Hydroxyapatite and α TCP Calcium Phosphate by Electrospinning Method

Natural bone is formed by a complex composite, essentially constituted of biological apatite and fibers of collagen. The combination of materials such as biopolymers and bioceramics may result in an interesting material for application in bone tissue regeneration. This work aims to obtain polymeric fibers containing Poly (Lactic-co-Glycolic Acid) and Poly (Isoprene), supplemented with hydroxyapatite (HA) and α-tricalcium phosphate (TCP). The thermal, mechanical and morphological properties of the fibers were evaluated . Even presenting a larger diameter, fibers with α-TCP presented lower elastic modulus than fibers with HA. Both fibers presented similar thermal behavior, with glass transition temperature in the same range that the one presented by raw PLGA and similar degradation temperatures. Is safe to say that the presence of ceramics in the fibers have a potential for further investigations aiming bone tissue regeneration.
Antioxidant therapy for management of oxidative stress induced hypertension

Abstract Hypertension is considered as the most common risk factor for cardiovascular diseases, also is regarded as a leading cause of the mortality and morbidity worldwide. The mechanisms underlying the pathological process of hypertension are not completely explained. However, there is growing evidence that increased oxidative stress plays an important role in the pathophysiology of hypertension. Several preclinical studies and clinical trials have indicated that antioxidant therapy is important for management of hypertension, using antioxidants compounds such as alpha tocopherol (Vit E) and ascorbic acid (Vit C), polyphenols with others and some antihypertensive drugs that are now in clinical use (e.g. ACEIs, ARBs, novel B-blockers, dihydropyridine CCBs) which have antioxidative pleiotropic effects. The purpose of this review is to highlight the importance of antioxidant therapy for management of oxidative stress induced hypertension. Furthermore, we review the current knowledge in the oxidative stress and its significance in hypertension.
Well-done meat intake and the risk of breast cancer.

BACKGROUND Heterocyclic amines, mutagens formed in meats cooked at high temperatures, have been demonstrated as mammary carcinogens in animals. We conducted a nested, case-control study among 41836 cohort members of the Iowa Women's Health Study to evaluate the potential role of heterocyclic amines and intake of well-done meat in the risk for human breast cancer. METHODS A questionnaire was mailed to individuals in the cohort who had breast cancer diagnosed during the period from 1992 through 1994 and a random sample of cancer-free cohort members to obtain information on usual intake of meats and on meat preparation practices. Color photographs showing various doneness levels of hamburger, beefsteak, and bacon were included. Multivariate analysis was performed on data from 273 case subjects and 657 control subjects who completed the survey. RESULTS A dose-response relationship was found between doneness levels of meat consumed and breast cancer risk. The adjusted odds ratios (ORs) for very well-done meat versus rare or medium-done meat were 1.54 (95% confidence interval [CI]=0.96-2.47) for hamburger, 2.21 (95% CI=1.30-3.77) for beef steak, and 1.64 (95% CI=0.92-2.93) for bacon. Women who consumed these three meats consistently very well done had a 4.62 times higher risk (95% CI=1.36-15.70) than that of women who consumed the meats rare or medium done. Risk of breast cancer was also elevated with increasing intake of well-done to very well-done meat. CONCLUSIONS Consumption of well-done meats and, thus, exposures to heterocyclic amines (or other compounds) formed during high-temperature cooking may play an important role in the risk of breast cancer.
Circulating and disseminated tumor cells: diagnostic tools and therapeutic targets in motion

Enumeration of circulating tumor cells (CTCs) in peripheral blood with the gold standard CellSearchTM has proven prognostic value for tumor recurrence and progression of metastatic disease. Therefore, the further molecular characterization of isolated CTCs might have clinical relevance as liquid biopsy for therapeutic decision-making and to monitor disease progression. The direct analysis of systemic cancer appears particularly important in view of the known disparity in expression of therapeutic targets as well as epithelial-to-mesenchymal transition (EMT)-based heterogeneity between primary and systemic tumor cells, which all substantially complicate monitoring and therapeutic targeting at present. Since CTCs are the potential precursor cells of metastasis, their in-depth molecular profiling should also provide a useful resource for target discovery. The present review will discuss the use of systemically spread cancer cells as liquid biopsy and focus on potential target antigens.
An Active Learning Approach to Finding Related Terms

We present a novel system that helps non-experts find sets of similar words. The user begins by specifying one or more seed words. The system then iteratively suggests a series of candidate words, which the user can either accept or reject. Current techniques for this task typically bootstrap a classifier based on a fixed seed set. In contrast, our system involves the user throughout the labeling process, using active learning to intelligently explore the space of similar words. In particular, our system can take advantage of negative examples provided by the user. Our system combines multiple pre-existing sources of similarity data (a standard thesaurus, WordNet, contextual similarity), enabling it to capture many types of similarity groups ("synonyms of crash," "types of car," etc.). We evaluate on a hand-labeled evaluation set; our system improves over a strong baseline by 36%.
Effects of Meaning-Preserving Corrections on Language Learning

We present a computational model of language learning via a sequence of interactions between a teacher and a learner. Experiments learning limited sublanguages of 10 natural languages show that the learner achieves a high level of performance after a reasonable number of interactions, the teacher can produce meaning-preserving corrections of the learner's utterances, and the learner can detect them. The learner does not treat corrections specially; nonetheless in several cases, significantly fewer interactions are needed by a learner interacting with a correcting teacher than with a non-correcting teacher.
Achievements and Challenges in Antiviral Drug Discovery

The last 40 years have seen the development of several antiviral drugs with therapeutic value in treating life-threatening or debilitating diseases such as those caused by HIV, hepatitis B virus, herpesviruses (such as herpes simplex virus and varicella zoster virus) and influenza virus. These relatively recent advances have been due to technical breakthroughs in the cultivation of viruses in the laboratory, identification of viral enzymes and, more recently, their molecular biology. We describe here the antecedence of several of the existing antivirals and their strengths and weaknesses. We indicate where the major challenges lie for future improvements of current therapies and possible new indications, such as hepatitis C virus and papillomavirus. We also describe how current antiviral therapies are restricted to a rather limited number of viral diseases of sufficient interest to the pharmaceutical industry. Finally we describe the potential threat of emerging viruses and bio-weapons and the challenges that they present to therapy.
Artificial nutrition and hydration at the end of life: Ethics and evidence

The case of Terri Schiavo resulted in substantial media attention about the use of artificial nutrition and hydration (ANH) especially by percutaneous endoscopic gastrostomy (PEG). In this article, I review ethical and legal principles governing decisions to choose or forgo ANH at the end of life, including issues of autonomy and decision-making capacity, similarities and differences between ANH and other medical treatments, the role of proxies when patients lack decision-making capacity, and the equivalence of withholding and withdrawing treatment. Evidence for palliative or life-sustaining benefits for ANH are reviewed in three disease processes: amyotrophic lateral sclerosis (ALS), cancer, and dementias, including Alzheimer's disease. Although more recent studies suggest a possible palliative role for ANH in ALS and terminal cancer, feeding tubes do not appear to prolong survival or increase comfort in advanced dementia of the Alzheimer's type.
Quantification of gut lesions in a subclinical necrotic enteritis model

Currently Clostridium perfringens-induced necrotic enteritis is a major problem in broiler flocks. In the present study, broilers were inoculated with a combination of Eimeria maxima or overdose coccidial vaccine (one inoculation) with C. perfringens (repeated inoculations). Single C. perfringens, E. maxima or an overdose of live coccidial vaccine inoculations did not result in grossly visible necrotic gut lesions, while combined inoculation resulted in typical necrotic lesions at approximately 4 days after inoculations with C. perfringens in approximately one-half of the inoculated animals. Semi-quantitative histological lesion scoring was done to evaluate gut damage in gut sections of animals in which no gross necrotic lesions were detected. This included scoring of hyperaemia, haemorrhages, the amount of red blood cells and protein precipitate in the lumen, villus fusion and epithelial defects. The villus length and the villus length/crypt depth ratio were also analysed. This approach proved to be discriminative between single E. maxima infection, overdose of coccidial vaccine or C. perfringens inoculations and the non-inoculated control group, and between the double-inoculated and single-inoculated groups. In general, the highest histological scores for gut lesions were observed in the double-inoculated groups, but the single-inoculated groups had higher scores than the control group. It was concluded that oral inoculation of broilers with an overdose of live coccidial vaccine in combination with multiple oral C. perfringens inoculations is a suitable model for necrotic enteritis without inducing mortality of the animals. C. perfringens and Eimeria act synergistically in inducing grossly visible gut damage.
An embedded fibre optic sensor for impact damage detection in composite materials

A structura! ly embedded fibre op tic damage detection sensor for composite materials is described. The system is designed specifically for the detection of barely visible damage resulting from low velocity impacts in Kevlar-epoxy laminates. By monitoring the light transmission properties of optical fibre embedded in the composite, it has been shown that the integrity of the material can be accurately determined. The effect of severa! parameters on the sensitivity of the system has been investigated, including the effect of the optical fibre orientation and depth of embedding within the cornposite. A novel surface treatment has a! so been developed for the optica! fibres to ensure they will fracture at the requisite dainage level. The influence of the optica! fibre sensors on the tensile and compressive materia! properties and on the impact resistance of.the laminate has also been studied. Extensive experimental results from impact tests are reporte~ and a numerical model of the impact event is presented which is able to predict and model the damage mechanism and sensor system. A new and powerful method of non. destructive evaluation for translucent composite materials based on image enhanced backlighting is also described.
Experimental of Energy Dissipation Characteristics of Metal Rubber

The metal rubber is a kind of material for vibration control. In this paper, experimental research on characteristics of energy dissipation of metal rubber is exploited, and the relation between metal rubber stiffness and the amplitude of relative density and load. The relative between relative density and characteristics of energy dissipation is researched, in the excitation of displacement and load respectively. By comparing variation of the deformation and load with time, we found that the cycle of deformation and load is the same, but the deformation is still lag behind load. The research provided a basis for the application of metal rubber.
Hierarchical Manifold Learning for Regional Image Analysis

We present a novel method of hierarchical manifold learning which aims to automatically discover regional properties of image datasets. While traditional manifold learning methods have become widely used for dimensionality reduction in medical imaging, they suffer from only being able to consider whole images as single data points. We extend conventional techniques by additionally examining local variations, in order to produce spatially-varying manifold embeddings that characterize a given dataset. This involves constructing manifolds in a hierarchy of image patches of increasing granularity, while ensuring consistency between hierarchy levels. We demonstrate the utility of our method in two very different settings: 1) to learn the regional correlations in motion within a sequence of time-resolved MR images of the thoracic cavity; 2) to find discriminative regions of 3-D brain MR images associated with neurodegenerative disease.
Spindle Assembly in Xenopus Egg Extracts: Respective Roles of Centrosomes and Microtubule Self-Organization

In Xenopus egg extracts, spindles assembled around sperm nuclei contain a centrosome at each pole, while those assembled around chromatin beads do not. Poles can also form in the absence of chromatin, after addition of a microtubule stabilizing agent to extracts. Using this system, we have asked (a) how are spindle poles formed, and (b) how does the nucleation and organization of microtubules by centrosomes influence spindle assembly? We have found that poles are morphologically similar regardless of their origin. In all cases, microtubule organization into poles requires minus end–directed translocation of microtubules by cytoplasmic dynein, which tethers centrosomes to spindle poles. However, in the absence of pole formation, microtubules are still sorted into an antiparallel array around mitotic chromatin. Therefore, other activities in addition to dynein must contribute to the polarized orientation of microtubules in spindles. When centrosomes are present, they provide dominant sites for pole formation. Thus, in Xenopus egg extracts, centrosomes are not necessarily required for spindle assembly but can regulate the organization of microtubules into a bipolar array.
Multi-center congestion estimation and minimization during placement

As technology advances, more and more issues need to be considered in the placement stage, e.g., wirelength, congestion, timing, coupling. It is very hard to consider all of them together at the same time. Thus it is good if we can optimize one cost function without affecting others. In this paper, we will study methods to optimize congestion in placement without inflicting degradations/violations in other objectives or constraint. We give a mathematical equation to predict the overflow within a region using a normal distribution approximation. According to experiments, this equation does give a good estimation of overflow. We used this equation to find the smallest regions which have enough routing resource to alleviate the congestion and propose the flexible expansion scheme in our multi-center congestion reduction (MC2R) algorithm. Experimental results show that generally there is a correlation between the amount of reduction in congestion and the amount of change made to the placement: the more we change the placement, the more reduction in congestion we will get. However, the flexible expansion scheme is very effective in helping us reduce congestion while making only little change to the placement. Comparing to the full expansion scheme (49% congestion reduction and 6.5% change in placement), the flexible expansion scheme together with MC2 R algorithm can reduce congestion by almost the same amount (42%) with much less change made to the placement. (1.8%).
Research on a new type of magneto-optical multilayer films (MOMF) isolator

One-dimensional magneto-optical (MO) photonic crystals display enhanced MO effect due to the localization of light, it can be used to fabricate small-size optical isolator with only tens of micros which can enlarge the integration of system. A transfer matrix method (TMM) that is suitable for solving the problems of the propagation of polarized light in anisotropic media at an arbitrary incidence angle, is described detailedly in this paper. Using this method, we discussed two types of reflection-mode "sandwich structure" of MOMF isolator, and found that the structure with thicker MO layer has advantages in working stability and fabrication.
A Beam-Search Decoder for Normalization of Social Media Text with Application to Machine Translation

Social media texts are written in an informal style, which hinders other natural language processing (NLP) applications such as machine translation. Text normalization is thus important for processing of social media text. Previous work mostly focused on normalizing words by replacing an informal word with its formal form. In this paper, to further improve other downstream NLP applications, we argue that other normalization operations should also be performed, e.g., missing word recovery and punctuation correction. A novel beam-search decoder is proposed to effectively integrate various normalization operations. Empirical results show that our system obtains statistically significant improvements over two strong baselines in both normalization and translation tasks, for both Chinese and English.
Effect of needle length, electrospinning distance, and solution concentration on morphological properties of polyamide-6 electrospun nanowebs

Nowadays, thanks to the electrospinning process, polymeric fibers in nanoscale diameters (10–500 nm) are easily producible. During the last decade, the electrospinning technique has been greatly investigated and developed. One of the most important fields of study on the electrospinning process is the influence of effective parameters on electrospun nanofibers and nanoweb properties. In this study, using polyamide-6 (PA-6)/formic acid polymer solution, three important parameters of the electrospinning process, including polymer solution concentration, needle-tip-to-collector distance, and needle length, were precisely studied. The solution concentration is a very important parameter that affects the nanowebs’ homogeneity and nanofibers’ diameter evenness. Scanning electron microscopy (SEM) analysis of the electrospun nanowebs showed that among five polymer solution concentrations (5, 10, 15, 20, and 25 wt%), 25 wt% was more suitable and provided the homogeneity and reproducibility of PA-6 nanowebs. It has been found that the needle-tip-to-collector distance had a considerable influence on the nanofibers’ diameter and the nanoweb collection zone. Morphological investigation and statistical studies showed that the nanofibers’ diameter increased with the reduction of the needle-tip-to-collector distance. Moreover, the average diameter of the nanoweb collection zone decreased by the reduction of this distance. The effect of needle length on the nanofibers’ morphology and nanowebs’ collection zone was investigated. Statistical analysis of the obtained results revealed that the increase of needle length significantly increased the average nanofibers’ diameter. Inversely, the diameter of the nanoweb collection zone reduced when needle length increased. All previously mentioned studies helped to define the optimal electrospinning condition to produce the bead-free, non-branched, and homogeneous PA-6 electrospun nanofibers and nanowebs.