Miracle-dz/UniFAR-FTUs huggingface dataset:
Methylation Analysis of Several Tumour Suppressor Genes Shows a Low Frequency of Methylation of CDKN2A and RARB in Uveal Melanomas

We have investigated the frequency of methylation of several tumour suppressor genes in uveal melanoma. As the loss of one copy of chromosome 3 (monosomy 3), which is found in about half of these tumours, is tightly associated with metastatic disease, a special emphasis was laid on genes located on this chromosome, including the fragile histidine triad (FHIT), von Hippel–Lindau (VHL), β-catenin (CTNNB1), activated leukocyte cell adhesion molecule (ALCAM) and retinoic acid receptor-β2 (RARB) genes. In addition, the methylation patterns of the CpG-rich regions 5′ of the E-cadherin (CDH1), p16/cyclin-dependent kinase inhibitor 2 A (CDKN2A) and retinoblastoma (RB1) genes were analysed by bisulphite genomic sequencing or methylation-specific PCR (MSP). Furthermore, the SNRPN and D15S63 loci, which are located in the imprinted region of chromosome 15, were included in the study. Aberrant methylation was detected in nine of 40 tumours analysed: The imprinted SNRPN and D15S63 loci were hypermethylated in three tumours, all of which retained both copies of chromosome 3. Methylated RARB alleles were detected in three tumours, whereas in three other tumours CDKN2A was found to be methylated. As we did not find RARB and CDKN2A preferentially methylated in tumours with monosomy 3, which is a significant predictor of metastatic disease, we suggest that these genes may play a causative role in the formation of uveal melanoma but not in the development of metastases.
Simultaneous dispersion and non-linearity compensation with OPC-DRA combination for a mm-wave radio-over-fiber transmission system

Optical phase conjugation (OPC) and distributed Raman amplifier (DRA) combination (OPC-DRA) is demonstrated as a potential enabling solution for reduction of signal fading due to interplay of self-phase modulation and group velocity dispersion of a sub-carrier multiplexed (SCM) mm-wave radio-over-fiber (RoF) transmission link. The present work is focused on the use of OPC-DRA combination for system performance improvement in terms of carrier to noise ratio (CNR) and the bit error rate (BER) of the SCM-RoF link. The analysis further shows that, introduction of DRA with proper pumping scheme significantly reduce fiber non-linearity resulting in improvement of the system performance in terms of BER, compared to the situation where only mid-way optical phase conjugation is used
Increased risk of restenosis after placement of gold-coated stents: results of a randomized trial comparing gold-coated with uncoated steel stents in patients with coronary artery disease.

BACKGROUND Gold is a highly biocompatible material. Experimental evidence suggests that coating the stent with a gold layer may have a beneficial influence. In this randomized trial, we assessed whether gold-coated stents were associated with a better clinical and angiographic outcome after coronary placement. METHODS AND RESULTS Patients with symptomatic coronary artery disease were randomly assigned to receive either a gold-coated Inflow stent (n = 367) or an uncoated Inflow stainless steel stent (n = 364) of identical design. Follow-up angiography was routinely performed at 6 months. The primary end point of the study was the occurrence of any adverse clinical event (death, myocardial infarction, or target-vessel revascularization) during the first year after stenting. At 30 days, there was no significant difference in the combined incidence of adverse events, with 7.9% in the gold-stent group versus 5.8% in the steel-stent group (P = 0.25). The incidence of angiographic restenosis (> or =50% diameter stenosis) was 49.7% in the gold-stent group and 38.1% in the steel-stent group (P = 0.003). One-year survival free of myocardial infarction was 88.6% in the gold-stent group and 91.8% in the steel-stent group (P = 0.14). One-year event-free survival was significantly less favorable in the gold-stent group (62.9% versus 73.9% in the steel-stent group; P = 0.001). CONCLUSIONS Coating steel stents with gold had no significant influence on the thrombotic events observed during the first 30 days after the intervention. However, gold-coated stents were associated with a considerable increase in the risk of restenosis over the first year after stenting.
How to Determine that All the Roots of a TranscendentalPolynomial Have Negative Real Parts ?

A transcendental polynomial which has all its roots lying in the left half-plane is called stable. In this paper, the stability of transcendental polynomials which are nearly as general as those discussed by L.S. Pontryagin are investigated through direct analytic method. For application of the method presented in this paper,the asymptotic stability of some diierential-diierence equations is investigated.
A Fuzzy & KL Based Reduced Reference ImageQuality

Reduced-reference (RR) image quality measures aim to predict the visual quality of distorted images with only partial information about the reference images. In this paper, in first stage uses present thresholding technique between probability distribution of local entropy of reference and their corresponding images using relative entropy (also known as the Kullback-Leiber discrimination distance function) as a criterion of thresholding of probability distribution of local entropy between references and distorted of their reference image. After then we create a model FIS (Fuzzy Inference System) and then use as input KLD and get quality score of distortedimage.
G T ] 4 A ug 2 00 6 Crowell ’ s Derived Group and Twisted Polynomials

The derived group of a permutation representation, introduced by R.H. Crowell, unites many notions of knot theory. We survey Crowell’s construction, and offer new applications. The twisted Alexander group of a knot is defined. Using it, we obtain twisted Alexander modules and polynomials. Also, we extend a wellknown theorem of Neuwirth and Stallings giving necessary and sufficient conditions for a knot to be fibered. Virtual Alexander polynomials provide obstructions for a virtual knot that must vanish if the knot has a diagram with an Alexander numbering. The extended group of a virtual knot is defined, and using it a more sensitive obstruction is obtained.
A highly-automated RPAS mission manager for integrated airspace

This paper addresses the problem of defining Mission Plans for Remotely Piloted Aircraft Systems (RPAS) and designing a software architecture for executing such plans. A RPAS Mission Plan for integrated airspace usually includes flight procedures in controlled airspace as well as procedures for the operations area, which usually is in a non-controlled airspace. Procedures for controlled airspaces must adhere to standard regulations, but nothing has been yet standardised for the operation in non-controlled airspaces. Some coherent extension to traditional Flight Plans is needed to specify all flight procedures in a coherent manner. This paper advocates extending ARINC-424 route definitions with RPAS specific features. On the other hand, RPAS do need a higher level of automation than manned aircraft due to many reasons: lower situational awareness, need for higher autonomy upon C2 link failures, or higher accuracy operation. This fact has important implications on the degree of automation and the definition of the Mission Plan. Firstly, different operational modes with different levels of automation are required. Secondly, traditional Flight Plans should be also extended to specify automatic flight procedures triggered by events like C2 link failures, or collision avoidance that could lead to unsafe conditions. The paper also discusses in detail the design of a Mission Manager for supporting the previous features based on a three-tiered (3T) architecture. The porting process of this architecture to an ARINC-653 compliant execution platform based on XtratuM is also introduced.
Unbounded Fredholm modules and double operator integrals

Abstract In noncommutative geometry one is interested in invariants such as the Fredholm index or spectral flow and their calculation using cyclic cocycles. A variety of formulae have been established under side conditions called summability constraints. These can be formulated in two ways, either for spectral triples or for bounded Fredholm modules. We study the relationship between these by proving various properties of the map on unbounded self adjoint operators D given by ƒ(D) = D(1 + D 2)−1/2. In particular we prove commutator estimates which are needed for the bounded case. In fact our methods work in the setting of semifinite noncommutative geometry where one has D as an unbounded self adjoint linear operator affiliated with a semi-finite von Neumann algebra ℳ. More precisely we show that for a pair D, D 0 of such operators with D – D 0 a bounded self-adjoint linear operator from ℳ and , where 𝓔 is a noncommutative symmetric space associated with ℳ, then . This result is further used to show continuous differentiability of the mapping between an odd 𝓔-summable spectral triple and its bounded counterpart.
Geo-spatial Big Data Mining Techniques

As stated in literature by several authors, there has been literally big-bang explosion in data acquired in recent times. This is especially so about the geographical or geospatial data. The huge volume of data acquired in different formats, structured, unstructured ways, having large complexity and non-stop generation of these data have posed an insurmountable challenge in scientific and business world alike. The conventional tools, techniques and hardware existing about a decade ago have met with the limitations in handling such data. Hence, such data are termed as big data. This has necessitated inventing new software tools and techniques as well as parallel computing hardware architectures to meet the requirement of timely and efficient handling of the big data. The field of data mining has been benefitted from these evolutions as well. This article reviews the evolution of data mining techniques over last two decades and efforts made in developing big data analytics, especially as applied to geospatial big data. This is still a very actively evolving field. There will be no surprise if some new techniques are published before this article appears in print.
Collision properties of ultracold 133Cs atoms

We present a theoretical analysis of numerous magnetically tunable Feshbach resonances measured by Chin et al. [preceding Letter, Phys. Rev. Lett. 85, 2717 (2000)] at fields of up to 25 mT. This analysis provides the most accurate characterization of the collisional properties of ground state Cs atoms currently available and clearly shows, in contrast to previous work, that Bose-Einstein condensation of 133Cs cannot be ruled out. The X1Sigma(+)(g) and a(3)Sigma(u) scattering lengths are constrained to (280+/-10)a(0) and (2400+/-100)a(0), respectively ( 1a(0) = 0.052 917 7 nm), and the van der Waals C6 coefficient to 6890+/-35 a.u. (1 a.u. = 0.095 734 5 x10(-24) &Jdot;nm(6)).
Behaviour Subdivision and Generalization of Rules in Rule-Based Control of the ATRON Self-Reconfigurable Robot

The complexity of control is a major problem in self-reconfigurable robots. In this paper we present a method for reducing the complexity of controller design by dividing a global behaviour into sub-behaviours realized by sets of rules dependent on the local configuration. The coordination of sub-behaviours is realized by behaviour arbitrators based on simple distributed signals. Furthermore, the generalization of simple rules into fewer, but more general rules, resembling even smaller subbehaviours, is investigated in terms of changes of the global behaviour due to the introduction of overgeneral rules. It is shown by example that more general rules perform better, in terms of speed of the global behaviour, than simpler rules. The proposed methods are evaluated by constructing a cluster flow behaviour for a large group of ATRON modules.
Five enunciations of empowerment in participatory design

Participatory design has been defined as having 'user's democratic participation and empowerment at its core' (Correia and Yusop, 2008). The PD discourse has a strong moral and rhetorical claim by its emphasis on users' empowerment. This paper is a result of a student project, guided by a curiosity about how empowerment is enunciated in the PD field today. In a literature-review of academic papers from the proceedings of PDC 2008 we found that empowerment is enunciated in five different ways which can be translated into 5 categories: 1) Specific user groups 2) Direct democracy 3) The users' position 4) Researchers' practice 5) Reflexive practice. These categories exist conjointly in the literature and suggest that empowerment is not just a moral and politically correct design goal, but a challenged and complex activity.
Airport Presence as Product Differentiation

There is now widespread recognition that an airline's operation at a given airport greatly affects its competitive position on routes flown out of that airport (see M. Levine, 1987; S. Borenstein, 1989; S. Morrison and C. Winston, 1989; and myself, 1989, among many others.) Airlines typically defend any competitive advantage as stemming from the lower costs and better service that are said to be generated by hub-and-spoke route systems. Airline critics typically respond that airlines gain market power by dominating individual airports. Both views are at least plausible. Huband-spoke transportation networks reduce the number of round-trips necessary to carry a given number of passengers on a given set of itineraries, while increasing the number of passenger miles flown. If there are sufficient economies of scale in plane size, then the advantages of hubbing can overcome the disadvantage in passenger miles, resulting in lower total costs. By pooling passengers with different ultimate destinations, a hubbed system can also offer more frequent flights than would be economically feasible under a nonstop system. It also appears, however, that airlines gain other advantages from a large presence at an airport. Incumbent airlines are the major source of financing for many airports and therefore gain a large degree of bureaucratic control over airport operations. This control may enable them to block the entry or expansion of rivals. Airlines with a large presence in a given city also gain advantages from frequent flyer plans and nonlinear travel agent commission schedules (see, again, Levine and others). If the bureaucratic and marketing advantages of airport presence are sufficient to prevent most attempts at entry, then incumbents may gain the ability to exercise traditional "market power" by restricting output and driving up prices. This paper argues that both simple costreducing and naive market power stories are inappropriate for the airline industry. I present a model in which consumers are willing to pay a premium for the services of the dominant airline; this premium may be related to a number of factors, including flight frequency, frequent flier miles, and travel agent commission overrides. This model has the advantage of treating oligopoly product differentiation in an explicit way, of treating price as an endogenous variable, and of allowing for airport presence to affect both costs and demand.
The comparison of common cancer types and the coincidence of concomitant chronic diseases between palliative home care patients in Lodz Voivodeship and the general Polish population

Introduction The continued growth in the number of elderly with cancer and age-related chronic diseases will cause in Poland an increase in demand for palliative care. The aim of the study was to identify chronic comorbidities and cancer types in palliative home care patients and to compare their incidence with the general Polish population. Material and methods The data was obtained from 543 patients who received palliative home care between 2005-2009. The occurrence of the most common chronic conditions such as arterial hypertension, ischemic heart disease, diabetes, chronic pulmonary diseases and central nervous system diseases were analysed together with the cancer types. Results The study group included 259 women (47.7%) and 284 men (52.3%) aged 25-91 years old. The most common primary neoplasm locations for men were lung (28.2% vs. 21.4% in general population) and colorectal cancer (18.7% vs. 11.4% in general population), and in women breast (19.7% vs. 22.8% in general population) and colorectal cancer (17.4% vs. 9.2% in general population). The incidence of ischemic heart disease, diabetes, and chronic pulmonary diseases was significantly different in comparison to the general populations (47.0% vs. 11.3%; 20.3% vs. 6.8%; 16.6% vs. 27.5%, respectively). The mean number of concomitant diseases was 1.6 for women and 1.8 for men vs. 1.7 and 1.2 in the general Polish population respectively. Conclusions The majority of the patients had concomitant disease, with cardiovascular diseases being most common. The most common primary neoplasm diagnoses in palliative home care patients were lung and colorectal cancer, which corresponds to the cancer prevalence in the general population.
New Bridgeless DCM Sepic PFC Rectifier with Low Conduction and Switching Losses

New bridgeless single-phase ac–dc power factor correction (PFC) rectifier based on Sepic topology is proposed. The absence of an input diode bridge and the presence of only two semiconductor switches in the current flowing path during each switching cycle result in less conduction losses and improved thermal management compared to the conventional Sepic PFC converter. The proposed topology is designed to work in discontinuous conduction mode (DCM) to achieve almost unity power factor in a simple and effective manner. The DCM operation gives additional advantages such as zero-current turn-on in the power switches, zero-current turn-off in the output diode and reduces the complexity of the control circuitry. The proposed rectifier is theoretically nvestigated. Performance comparisons between the proposed and conventional Sepic PFC rectifiers are performed. Simulation and experimental results are provided for a design example of a 65W/48-V at 100-Vrms line voltage to evaluate the performance of the proposed PFC rectifier
Hormonal Regulation of Ovarian Bursa Fluid in Mice and Involvement of Aquaporins

In rodent species, the ovary and the end of oviduct are encapsulated by a thin membrane called ovarian bursa. The biological functions of ovarian bursa remain unexplored despite its structural arrangement in facilitating oocytes transport into oviduct. In the present study, we observed a rapid fluid accumulation and reabsorption within the ovarian bursa after ovarian stimulation (PMSG-primed hCG injection), suggesting that the ovarian bursa might play an active role in regulating local fluid homeostasis around the timing of ovulation. We hypothesized that the aquaporin proteins, which are specialized channels for water transport, might be involved in this process. By screening the expression of aquaporin family members (Aqp1-9) in the ovarian tissue and isolated ovarian bursa (0, 1, 2 and 5 h after hCG injection), we found that AQP2 and AQP5 mRNA showed dynamic changes after hCG treatment, showing upregulation at 1–2 h followed by gradually decrease at 5 h, which is closely related with the intra-bursa fluid dynamics. Further immunofluorescence examinations of AQP2 and AQP5 in the ovarian bursa revealed that AQP2 is specifically localized in the outer layer (peritoneal side) while AQP5 localized in the inner layer (ovarian side) of the bursa, such cell type specific and spatial-temporal expressions of AQP2 and 5 support our hypothesis that they might be involved in efficient water transport through ovarian bursa under ovulation related hormonal regulation. The physiological significance of aquaporin-mediated water transport in the context of ovarian bursa still awaits further clarification.
University of Texas Rio Grande Valley TREC LiveQA 2016: Using Topic Modeling to Answer Complex Questions

This paper describes the system submitted to the TREC 2016 LiveQA track. This year, the TREC 2016 LiveQA track consists of implementing a web service to answer user-submitted questions. The newest unanswered question from Yahoo! Answers will be posted to the web service, a question every minute for 24 hours. The implementation described in this paper uses natural language processing (NLP) to extract keywords from the question given as input. A web search together with a Yahoo! Answer search is used to select candidate answers. A latent dirichlet allocation (LDA) model is trained in order to compute a topic distribution of the different candidate answers. Finally, the Jensen-Shannon distance is used as similarity measure between the candidate answers and the question given as input. This implementation performed better than the average scores.
Cyber-Attacks and the Exploitable Imperfections of International Law

Cyber-Attacks and the Exploitable Imperfections of International Law reveals elements of existing jus ad bellum and jus in bello regimes that are unable to accommodate the threats posed by cyber-attacks. It maps out legal gaps, deficiencies, and uncertainties, which international actors may seek to exploit to their political benefit.
Baselines for Greenhouse Gas Reductions : Problems , Precedents , Solutions

Acknowledgements: Much of section 7 on lessons from demand-side-management is based on a background paper by Daniel Violette and Shannon Ragland of Hagler-Bailly Consulting. The discussion of the US emissions reductions credits draws on a background paper by Byron Swift of the Environmental Law Institute. The menu-choice method for baseline revelation was proposed in background material by Tracy Lewis. I am grateful to Johannes Heister and Charles Feinstein for helpful discussions and comments. However, all interpretations, conclusions, and errors are mine.
Molecular Edg 8 / S 1 P 5 : An Oligodendroglial Receptor with Dual Function on Process Retraction and Cell Survival

C. Jaillard,1* S. Harrison,2* B. Stankoff,1 M. S. Aigrot,1 A. R. Calver,2 G. Duddy,2 F. S. Walsh,3 M. N. Pangalos,4 N. Arimura,5 K. Kaibuchi,5 B. Zalc,1 and C. Lubetzki1 1Biologie des Interactions Neurones/Glie, Institut National de la Santé et de la Recherche Médicale and Université Pierre et Marie Curie, Unité Mixte de Recherche 711, Institut Fédératif de Recherche des Neurosciences, Hôpital de la Salpêtrière, F-75651 Paris, France, 2GlaxoSmithKline, New Frontiers Science Park, Harlow, Essex CM19 5AW, United Kingdom, 3Wyeth Research Discovery, Collegeville, Pennsylvania 19426, 4Wyeth Research, Neuroscience Discovery, Princeton, New Jersey 08852, and 5Department of Cell Pharmacology, Nagoya University Graduate School of Medicine Tsurumai, Showa, Nagoya 466-8550, Japan
Embedded System Security

From cars to cell phones, video equipment to MP3 players, and dishwashers to home thermostats - embedded computers increasingly permeate our lives. But security for these systems is an open question and could prove a more difficult long-term problem than security does today for desktop and enterprise computing. Security issues are nothing new for embedded systems. However, as more embedded systems are connected to the Internet, the potential damages from such vulnerabilities scale up dramatically. Internet connections expose applications to intrusions and malicious attacks. Unfortunately, security techniques developed for enterprise and desktop computing might not satisfy embedded application requirements.