Miracle-dz/UniFAR-FTUs huggingface dataset:
CD14-dependent and CD14-independent signaling pathways in murine macrophages from normal and CD14 knockout mice stimulated with lipopolysaccharide or taxol.

The antitumor agent, Taxol, shares with bacterial LPS the ability to activate murine macrophages, and its LPS-mimetic effects are blocked by LPS analogue antagonists. Since CD14 is central to the recognition of LPS by macrophages, we sought to examine a role for CD14 in the response to Taxol vs LPS. A comparison of responses of macrophages from wild-type mice with those from mice lacking CD14 due to a targeted disruption of the CD14 gene (CD14-deficient knockout (CD14KO)) revealed that like LPS, Taxol induces both CD14-dependent and -independent pathways of gene activation, although the CD14 dependency of Taxol stimulation is much less striking than that observed with LPS. The macrophage interaction with low concentrations of LPS (< or = 10 ng/ml) is largely CD14 dependent, as evidenced by the lack of induction of TNF-alpha, IL-1beta, and interferon-inducible protein-10 (IP-10) genes by CD14KO macrophages cultured in the absence of soluble CD14 (i.e., in autologous CD14KO -/- mouse serum). However, at high concentrations of LPS or Taxol, a CD14-independent pathway of activation is observed: this pathway leads to minimal IP-10 gene induction, even though induction of TNF-alpha and IL-1beta occurs. Measurements of TNF secretion followed a similar pattern to that observed at the level of steady state mRNA. These data suggest the existence of two pathways of activation by both LPS and Taxol: one that is CD14 dependent and leads to induction of TNF-alpha, IL-1beta, and IP-10 gene induction, and a CD14-independent pathway that results in the induction of TNF-alpha and IL-1beta, with minimal induction of IP-10.
Embedding Tarskian Semantics in Vector Spaces

We propose a new linear algebraic approach to the computation of Tarskian semantics in logic. We embed a finite model M in first-order logic with N entities in N-dimensional Euclidean space R^N by mapping entities of M to N dimensional one-hot vectors and k-ary relations to order-k adjacency tensors (multi-way arrays). Second given a logical formula F in prenex normal form, we compile F into a set Sigma_F of algebraic formulas in multi-linear algebra with a nonlinear operation. In this compilation, existential quantifiers are compiled into a specific type of tensors, e.g., identity matrices in the case of quantifying two occurrences of a variable. It is shown that a systematic evaluation of Sigma_F in R^N gives the truth value, 1(true) or 0(false), of F in M. Based on this framework, we also propose an unprecedented way of computing the least models defined by Datalog programs in linear spaces via matrix equations and empirically show its effectiveness compared to state-of-the-art approaches.
Galloylglucoses of low molecular weight as mordant in electron microscopy. I. Procedure, and evidence for mordanting effect

Gallotannin, consisting mainly of low molecular weight esters such as penta- and hexagalloylglucoses (commercially available as tannic acid produced from Turkish nutgall), can be used for increasing and diversifying tissue contrast in electron microscopy. When applied on tissue specimens previously fixed by conventional methods (aldehydes and OsO4), the low molecular weight galloylglucoses (LMGG) penetrate satisfactorily the cells and induce general high contrast with fine delineation of extra- and intracellular structures, especially membranes. In some features, additional details of their intimate configuration are revealed. Various experimental conditions tested indicate that the LMGG display a complex effect on fixed tissues: they act primarily as a mordant between osmium-treated structures and lead, and concomitantly stabilize some tissue components against extraction incurred during dehydration and subsequent processing. Experiments with aldehyde blocking reagents (sodium borohydride and glycine) suggested that the LMGG mordanting effect is not dependent on residual aldehydes groups in tissues.
Reporting Two Fatalities Associated with the Use of 4-Methylethcathinone (4-MEC) and a Review of the Literature.

We report two fatalities that are related to the cathinone 4-methylethcathinone (4-MEC) and review the current knowledge of 4-MEC. Qualitative and quantitative analysis of 4-MEC was performed by validated high performance liquid chromatography-tandem mass spectrometry methods. In the first case a 22-year-old male died in hospital following collapse and seizures after using 4-MEC. Toxicological analysis of postmortem femoral blood revealed the presence of 4-MEC (0.167 mg/L), ethanol (27 mg/100 mL) and paracetamol (5 mg/L). Death was attributed solely to 4-MEC toxicity. The second case involved a 54-year-old man found with a taped plastic bag over his head. Toxicological analysis of postmortem femoral blood revealed the presence of 4-MEC (1.73 mg/L) along with ethanol (229 mg/100 mL), propranolol (0.036 mg/L), venlafaxine (0.284 mg/L) and its metabolite O-desmethylvenlafaxine (0.205 mg/L), and diazepam (<0.005 mg/L) and its metabolite nordiazepam (0.033 mg/L). Death was attributed primarily to asphyxiation. These cases and a review of the current knowledge of 4-MEC pharmacology/toxicology adds to the body of case material for 4-MEC and will assist with interpretation in postmortem toxicology cases in which 4-MEC is detected.
Values and Antisocial Behavior Among Spanish Adolescents

Abstract A number of studies have indicated that delinquent adolescents have characteristic value systems. However, most of these studies have adopted a “known-groups” design—that is, they have compared institutionalized delinquents and non-institutionalized adolescents, assuming those adolescents to be non-delinquent. Designs of this type do not distinguish effectively between the statistical effects of delinquency and of institutionalization. In this study, the authors investigated relationships between values and self-reported antisocial behavior in three adolescent groups: 435 school-attending boys, 529 school-attending girls, and 95 delinquent boys in juvenile rehabilitation centers or prisons. The results indicate that antisocial behavior is associated with hedonistic values and a lack of interest in conventional values and social values. These relationships cannot be explained by the institutionalization effects.
Validation and Psychometric Properties of the Resilience Scale-5 (RS-5): Results of a Representative Survey of the German General Population

Objectives: The aim of the present study was the validation of the Resilience Scale 5 (RS-5) developed by Von Eisenhart Rothe et al. in the general population, specifically younger population groups, as well as the establishment of norm values. That included the analysis of psychometric properties such as item and scale characteristics, factor structure, validity towards related psychological constructs, measurement invariance as well as comparison of means based on sociodemographic variables. Methods: The study sample (n=4972) can be considered representative of the general population and was acquired utilizing a sampling procedure that ensured random selection. A confirmatory factor analysis (CFA) was employed to confirm the uni-factorial structure of the questionnaire. Measurement invariance was tested using multigroup analysis. Pearson product-moment correlations were used to determine convergent validity towards related constructs. Results: The RS-5 showed satisfactory model fit. Item and scale characteristics, including reliability, were excellent. Measurement invariance for age, gender, and education groups was shown. Resilience mean comparisons showed significant differences for several sociodemographic groups, that should be further analyzed in future research. Norm values are reported. Conclusion: To sum up, the RS-5 is a reliable and valid measure of resilience for older and younger populations alike. It displays a good model fit and can be recommended for usage in research and clinical applications.
Graph Wavelet Alignment Kernels for Drug Virtual Screening

In this paper, we introduce a novel statistical modeling technique for target property prediction, with applications to virtual screening and drug design. In our method, we use graphs to model chemical structures and apply a wavelet analysis of graphs to summarize features capturing graph local topology. We design a novel graph kernel function to utilize the topology features to build predictive models for chemicals via Support Vector Machine classifier. We call the new graph kernel a graph wavelet-alignment kernel. We have evaluated the efficacy of the wavelet-alignment kernel using a set of chemical structure-activity prediction benchmarks. Our results indicate that the use of the kernel function yields performance profiles comparable to, and sometimes exceeding that of the existing state-of-the-art chemical classification approaches. In addition, our results also show that the use of wavelet functions significantly decreases the computational costs for graph kernel computation with more than ten fold speedup.
Identification of microRNAs differentially expressed in prostatic secretions of patients with prostate cancer

Prostate cancer (PCa) is one of the leading causes of cancer deaths in men. Since there are limited treatment options available for the advanced tumors, there is an urgent need for novel diagnostic tools for PCa. Prostate secretion samples (PSS) from 23 PCa and 25 benign prostate hyperplasia (BPH) patients were obtained from Urology Department of Bagcilar Educational and Research Hospital (Istanbul). MicroRNA (miRNA) profiling of eight PSS (four from BPH, four from PCa patients) was performed using microarray. Four of significantly deregulated miRNAs were further confirmed using quantitative reverse‐transcription PCR (qRT‐PCR). Statistical analysis was performed using Student's t‐test. ROC curves were plotted with SPSS‐15.0.
ConceptOnto: An upper ontology based on ConceptNet

The exponential growth of information has prompted the introduction of new technologies such as Semantic Web and Common Sense knowledge bases. To connect the different knowledge presentations together is a primary requirement, and ontologies are central we need for this transformation. In this paper we introduce ConceptOnto which is an ontology based on the ConceptNet knowledge base with extension of some of the other properties in some of the more acclaimed upper ontologies. Our goal in the creation of ConceptOnto is readability for humans, and maximizing the functionality while saving the generality of the ontology.
DYNAMICAL BEHAVIOR OF CONTINUOUS TICK DATA IN FUTURES EXCHANGE MARKET

We study the tick dynamical behavior of the bond futures in Korean Futures Exchange(KOFEX) market. Since the survival probability in the continuous-time random walk theory is applied to the bond futures transaction, the form of the decay function in our bond futures model is discussed from two kinds of Korean Treasury Bond(KTB) transacted recently in KOFEX. The decay distributions for survival probability are particularly displayed stretched exponential forms with novel scaling exponents $\beta$ $=$ 0.82(KTB 203) and $\beta$ $=$ 0.90(KTB112), respectively, for our small time intervals. We obtain the scaling exponents for survival probability $\epsilon$ $=$ 17 and 18 decayed rapidly in large time limit, and our results are compared with recent numerical calculations.
The behaviour of thiomolybdates in in vitro systems

The stability of potassium tetrathiomolybdate was studied in vitro using solutions with molybdenum, hydrogen ion and phosphate concentrations similar to those normally found in the rumen. Under these conditions K2[MoS4] hydrolysed rapidly and as a result the solution contained [MoS4]2−, [MoOS3]2−, [MoO2S2]2−, [HS]− and H2S in equilibrium. In view of this hydrolysis, in vivo studies of thiomolybdate on copper metabolism of sheep should not exclude the possibility that either sulphide or molybdate is responsible for any observed effect.
Risk Stratification for Sudden Cardiac Death: A Plan for the Future

Sudden cardiac death (SCD) remains a high priority public health problem necessitating a multi-pronged approach for treatment and prevention. Tachyarrhythmic sudden cardiac death (SCD-VT/VF; ie, death attributable to potentially reversible ventricular tachyarrhythmias [ventricular tachycardia (VT) or fibrillation (VF)]), is a major cause of SCD. Accurate assessment of risk for SCD-VT/VF is of critical importance to assist clinical decision-making regarding prescription of preventive therapies that reduce mortality. These therapeutic decisions include adherence to standard medical therapies, often in conjunction with tailored medications, implantable devices, catheter ablation, or heretofore untested treatments, such as spinal cord stimulation.1 In cases in which the therapy is invasive or carries its own risk, such as these latter interventions, each should be based on reliable demonstration of added benefit to the patient. Pre-emptive risk stratification for SCD-VT/VF has substantial implications to public health for the following reasons: (1) Heart disease remains the number 1 cause of death in the United States, with >600 000 deaths attributable to heart disease annually reported by the National Center for Health Statistics (http://www.cdc.gov/nchs/fastats/deaths.htm); (2) Approximately half of these deaths are estimated to be sudden; (3) Approximately 50% of all SCDs are the first recognized cardiac event; and (4) Only a minority of those who suffer out-of-hospital cardiac arrest will ultimately survive. Although the incidence of VF as a cause of out-of-hospital cardiac arrest is declining, it remains a leading cause.2 The introduction of the implantable cardioverter-defibrillator (ICD)—an effective, but costly therapy—has had meaningful, but limited, population impact on SCD2; thus, there are opportunities for new approaches (Figure) to address SCD. In particular, improved risk stratification techniques that identify individuals at high risk for SCD-VT/VF could have substantial impact,3 saving lives while stewarding medical resources for cases in which they are most effective. Since 2005, annual meetings …
Root Apex Transition Zone As Oscillatory Zone

Root apex of higher plants shows very high sensitivity to environmental stimuli. The root cap acts as the most prominent plant sensory organ; sensing diverse physical parameters such as gravity, light, humidity, oxygen, and critical inorganic nutrients. However, the motoric responses to these stimuli are accomplished in the elongation region. This spatial discrepancy was solved when we have discovered and characterized the transition zone which is interpolated between the apical meristem and the subapical elongation zone. Cells of this zone are very active in the cytoskeletal rearrangements, endocytosis and endocytic vesicle recycling, as well as in electric activities. Here we discuss the oscillatory nature of the transition zone which, together with several other features of this zone, suggest that it acts as some kind of command center. In accordance with the early proposal of Charles and Francis Darwin, cells of this root zone receive sensory information from the root cap and instruct the motoric responses of cells in the elongation zone.
Distribution of improved varieties of cassava and potential impact on root yield and disease reduction in Nigeria

Eleven improved varieties project were multiplied in 2009 by primary producers associated with the USAID/ IITA project Unleashing the Power of Cassava in Africa in response to the Food Price Crisis (UPoCA) in seven States of Nigeria. In 2010, stems from these multiplication farms were distributed to farmers in these States. Prior to the distribution exercise a baseline survey was conducted on 630 farm families to ascertain among other issues their perception of cassava mosaic disease and other cassava pests. At the end of the harvest 2010 planting season, a survey of a subset of the recipients (80 villages) showed that the farmers are better informed and are replacing local varieties with improved varieties but would still need more extension service support on the best time to harvest these varieties to minimize losses due to rot.
Time at confluence for human RPE cells: effects on the adherens junction and in vitro wound closure.

PURPOSE To determine how time at confluence affects the properties of cultured human retinal pigment epithelium (RPE) cells, with emphasis on the adherens junction. METHODS Cultures were maintained at confluence without passage for intervals to several months. Adherens junction proteins (N-cadherin, E-cadherin, alpha-catenin, beta-catenin, plakoglobin, and actin) and the proliferation marker Ki-67 were localized in the cultures by fluorescence microscopy, and in vitro wound healing was compared. Adherens junctions were analyzed for protein solubility in detergent buffers and sensitivity to disruption by treatment with anti-cadherin antibodies and low calcium conditions. RESULTS Compared with cultures in early-confluence (2-3 days), postconfluent cultures (weeks) had more mature adherens junctions characterized by a circumferential (rather than linear) actin organization, and a zonular (rather than punctate) distribution of more detergent resistant cadherin and catenins. Postconfluent cultures also had fewer Ki-67-positive cells and a higher cell packing density. Early-confluence cells migrated into in vitro wounds as dissociated single cells, whereas postconfluent cells moved as contiguous sheets, retaining an intact junction during wound-induced cell migration and proliferation. Mature junctions were not disrupted by treatment of living cells with N-cadherin antibodies, which bound to and remained detectable at junctions for several days. Calcium withdrawal displaced N-cadherin from mature junctions and rendered it more soluble, but the dominant circumferential pattern of actin was stable. Restoration of medium calcium resulted in a rapid (hours) recovery of a nearly complete zonular pattern of insoluble N-cadherin. CONCLUSIONS Over long postconfluent periods, cultured RPE cells became more growth quiescent, and intercellular cadherin adhesions became more stable, exhibiting increased resistance to calcium removal and greater retention of junctional integrity during in vitro wound closure. Consideration should be given to whether the behavior of RPE cells in postconfluent cultures, where intercellular adhesions are more mature, more closely simulates RPE cells in situ than cells in early-confluence cultures, which are more commonly used for analysis.
Supporting OLAP operations over imperfectly integrated taxonomies

OLAP is an important tool in decision support. With the help of domain knowledge, such as hierarchies of attribute values, OLAP helps the user observe the effects of various decisions. One assumption of most OLAP operations is that the available domain knowledge is precise. In particular, they assume that the hierarchy of values over which the user can navigate forms a taxonomy. In this paper, we first note that when multiple heterogeneous data sources are involved in the gathering of the data and the associated domain knowledge, the integrated knowledge-base, constructed by combining locally available taxonomies based on the concept matchings, may not be a taxonomy itself. Specifically, existence of intersections among concepts from different sources compromises the tree-structure of the integrated taxonomy and prevents effective use of hierarchical navigation techniques, such as drill-down and roll-up. To cope with this, we introduce concept un-classification, where a select few of the concepts are eliminated to ensure that the remaining structure is a navigable taxonomy, without concept intersections. Since un-classifying an originally classified data is not desirable, we consider ways to minimize un-classification in the process. We introduce a cost model which captures the imprecision caused by the un-classification process and we formulate the problem of finding an un-classification strategy which eliminates intersections and which adds minimal imprecision to the resulting structure. We show that, when performed naively, this task can be very costly and thus we propose a bottom-up preprocessing strategy which supports basic navigational analytics operations, such as drill-down and roll-up. Experiments over synthetic and real-life data verified the effectiveness and efficiency of our approach.
User performance and attitude towards schemes for alphanumeric data entry using restricted input devices

Abstract Results are reported from two usability trials in which a total of 14 schemes for alphanumeric data entry on television screens were evaluated. The seven schemes in the first trial used only the navigation and select keys on the TV remote control unit. The second trial used the best scheme from the first trial (slightly modified), a further six schemes using different combinations of the navigation and alphanumeric keys and a portable, infra-red keyboard. In both trials task completion rates and times were measured together with the number of keystrokes. User preferences were measured using attitude questionnaires and explicit ranking of the schemes. As expected, the keyboard was, overall, the best scheme-though not the most accurate. Where only a limited range of input keys were available, grid display schemes were preferred over menus and dynamic displays. Where an alphanumeric keypad was available on the remote control unit, a multiple press scheme was marginally preferred.
Squamous Cell Carcinoma of the Uterine Cervix: Patterns of Thoracic Metastases

RATIONALE AND OBJECTIVESDistant metastasis of cervical cancer, once considered rather uncommon, has become more common in recent years because of longer survival of the patients. The purpose of this study is to evaluate the radiographic patterns of its thoracic metastases correlating with the pathways of metastatic tumor spread. METHODSThe conventional radiographs (62 cases), thoracic computed tomography images (20 cases), and medical records of 62 patients with advanced squamous cell carcinoma of the uterine cervix with thoracic metastases who died of extensive disease and its complications during a recent 5-year period were reviewed retrospectively. RESULTS AND CONCLUSIONSIn addition to the most typical pattern of multiple pulmonary nodules (71%), mediastinal and hilar lymphadenopathy (32%) and pleural metastases (27%) were frequently observed. Rare findings included bone metastases (6%), endobronchial obstruction (5%), and lymphangitic carcinomatosis (3%). The mechanisms of metastasis in relation to the above manifestations are proposed.
Fault-tolerant average execution time optimization for general-purpose multi-processor system-on-chips

Fault-tolerance is due to the semiconductor technology development important, not only for safety-critical systems but also for general-purpose (non-safety critical) systems. However, instead of guaranteeing that deadlines always are met, it is for general-purpose systems important to minimize the average execution time (AET) while ensuring fault-tolerance. For a given job and a soft (transient) error probability, we define mathematical formulas for AET that includes bus communication overhead for both voting (active replication) and rollback-recovery with checkpointing (RRC). And, for a given multi-processor system-on-chip (MPSoC), we define integer linear programming (ILP) models that minimize AET including bus communication overhead when: (1) selecting the number of checkpoints when using RRC, (2) finding the number of processors and job-to-processor assignment when using voting, and (3) defining fault-tolerance scheme (voting or RRC) per job and defining its usage for each job. Experiments demonstrate significant savings in AET.