Miracle-dz/UniFAR-FTUs huggingface dataset:
Permissive hypotension in the extremely low birthweight infant with signs of good perfusion

Introduction: Many practitioners routinely treat infants whose mean arterial blood pressure in mm Hg is less than their gestational age in weeks (GA). Objective: To assess the effectiveness of utilising a combined approach of clinical signs, metabolic acidosis and absolute blood pressure (BP) values when deciding to treat hypotension in the extremely low birthweight (ELBW) infant. Methods: Retrospective cohort study of all live born ELBW infants admitted to our neonatal intensive care unit over a 4-year period. Patients were grouped as either normotensive (BP never less than GA), hypotensive and not treated (BP<GA but signs of good perfusion; we termed this permissive hypotension) and hypotensive treated (BP<GA with signs of poor perfusion). Results: 118 patients were admitted during this period. Blood pressure data were available on 108 patients. 53% of patients were hypotensive (mean BP in mm Hg less than GA in weeks). Treated patients had lower birth weight and GA, and significantly lower blood pressure at 6, 12, 18 and 24 h. Normotensive patients and patients designated as having permissive hypotension had similar outcomes. Mean blood pressure in the permissive group increased from 26 mm Hg at 6 h to 31 mm Hg at 24 h. In a logistic regression model, treated hypotension is independently associated with mortality, odds ratio 8.0 (95% CI 2.3 to 28, p<0.001). Conclusions: Blood pressure spontaneously improves in ELBW infants during the first 24 h. Infants hypotensive on GA criteria but with clinical evidence of good perfusion had as good an outcome as normotensive patients. Treated low blood pressure was associated with adverse outcome.
A Comparison of Long-Haul and Short-Haul Business Tourists of Hong Kong

A number of studies have demonstrated the impact of distance on the volume, profile and behavior of pleasure tourists. To date, none has examined the effect of distance on business tourists, even though they represent a significant share of all travel. Distance exerts two inter-related effects on travel. The decaying effect on demand with increased distance is well established. Distance also acts as a “filter”, advantaging some groups for short-haul travel and effectively excluding others from long-haul travel. This filtering effect results in substantially different observed behavior between short and long-haul pleasure markets. This study examines the filtering effect of distance on tourist profile and subsequent behavior of business travelers who visited Hong Kong. The sample includes eight short-haul and six long-haul markets. Substantial differences are observed in the profile and resultant behaviors of the two cohorts, although the differences are more subtle among business tourists than pleasure tourists.
A New Approach to Stockout Penalties

Classical inventory theory considers that stockouts generate penalty costs to the firm, often assumed to be proportional to the excess of demand over supply. While such a concept is sometimes appropriate, it does not correctly reflect the effect of loss of goodwill. The latter is characterized by the fact that a disappointed customer reacts in the future to change his purchasing habits. Thus the nature of the effect is that subsequent demand is perturbed, a phenomenon quite different from having an immediate penalty cost imposed. Models with this property are termed perturbed demand, abbreviated PD. In this paper, this concept is defined precisely, and some of its properties are developed. Some typical cases are solved to determine optimal policies when PD prevails.
Association between cognition and function in patients with Parkinson disease with and without dementia

Patients with Parkinson's disease (PD) often have cognitive deficits from the time of diagnosis. Except in patients with dementia, the impact of cognitive symptoms on daily function is not well documented. This study had two objectives: (1) to determine the functional significance of cognitive deficits in nondemented patients with PD and (2) to assess the sensitivity of two measures of global cognitive abilities to identify individuals with impaired ADL function. One hundred eleven subjects with PD and a range of cognitive abilities were included. Of these, 20 were diagnosed with PDD. All subjects were assessed with the Mattis Dementia Rating Scale to two (DRS‐2) and the Mini‐Mental State Examination (MMSE). ADL function was reported by an informant using the Alzheimer's Disease Cooperative Study Activities of Daily Living Inventory (ADCS‐ADL). The ability of the DRS‐2 and MMSE to capture the impact of cognitive impairment on ADL function was assessed in the entire cohort and in subsets of nondemented individuals. After adjustment for covariates, cognition as measured by the DRS‐2 was strongly related to ADL function in the entire cohort (partial correlation coefficient = 0.55, P < 0.001). The association remained strong when only nondemented subjects were included (r = 0.42, P < 0.001). The DRS‐2 was significantly more accurate than the MMSE, particularly for detecting milder degrees of ADL impairment (ROC area = 0.87 vs. 0.75, P = 0.0008). Cognition is associated with impairment in ADL function, even in nondemented patients with PD. However, sensitive cognitive assessment measures may be needed to identify these functionally relevant impairments. © 2010 Movement Disorder Society
Ownership, Liquidity, and Investment

This article documents a nonlinear relationship between insider shareholdings and the sensitivity of a firm's investment to its cash flow. As insider holdings increase from zero, investment-cash flow sensitivities rise sharply. This relationship weakens at higher levels of insider ownership, and I find some evidence that investment-cash flow sensitivities decrease slowly with insider holdings after a certain point. I argue that these results are inconsistent with the hypothesis that free-cash-flow problems cause the widely noted sensitivity of investment to cash flow. The results are consistent with the presence of asymmetric-information problems in the capital markets that are heightened when managers have a strong incentive to maximize shareholder returns.
PD-1 deficiency Enhances Humoral Immunity of Malaria 1 infection-treated vaccine

# Correspondence: Wenyue Xu, Department of Pathogenic Biology, Third Military Medical University, Chongqing, P. R. China, Tel: 86 23 68752236, Fax: 86 23 68752236, e-mail: xuwenyue@gmail.com; or Tingting Zhao, Institute of Immunology of PLA, Third Military Medical University, Chongqing, P.R. China. E-mail: 772108644@qq.com. IAI Accepted Manuscript Posted Online 2 March 2015 Infect. Immun. doi:10.1128/IAI.02621-14 Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Equality Constrained Robust Measurement Fusion for Adaptive Kalman-Filter-Based Heterogeneous Multi-Sensor Navigation

Constraints can provide additional aids to a multi-sensor integrated navigation system and hence can increase accuracy of the solution and enhance reliability of the system. To integrate the constraints with the data from the sensors, the traditional integration Kalman filter (IKF) needs to be reconstructed. A new algorithm, the so-called constrained adaptive robust integration Kalman filter (CARIKF) is presented, which implements adaptive integration upon the robust direct fusion solution. In the algorithm the raw observations from all heterogeneous sensors are corrected by the pseudoobservations derived from state equality constraint. The posterior covariances of the corrected observations are subsequently estimated upon the robust maximum-likelihood-type estimation (M-estimation) theory. The fusion state and its covariance are solved for all sensors further in the least squares (LS) sense. The pseudoobservations are constructed according to the estimated state and its covariance. They are further combined with the dynamic model of the host platform in an adaptive Kalman filter (AKF), from which a reliable and accurate navigation solution can be then obtained. A state constraint model is proposed upon Newton's forward differential extrapolation numerical method. To demonstrate performance of the CARIKF algorithm, simulations have been conducted in different dynamic and observation scenarios. Several algorithms are compared to evaluate the validity and efficiency of the CARIKF. The results show that the CARIKF is superior to other algorithms and can significantly improve the precision and reliability of the integrated solution.
Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade

Constitutive Hedgehog (Hh) pathway activity is associated with initiation of neoplasia, but its role in the continued growth of established tumors is unclear. Here, we investigate the therapeutic efficacy of the Hh pathway antagonist cyclopamine in preclinical models of medulloblastoma, the most common malignant brain tumor in children. Cyclopamine treatment of murine medulloblastoma cells blocked proliferation in vitro and induced changes in gene expression consistent with initiation of neuronal differentiation and loss of neuronal stem cell–like character. This compound also caused regression of murine tumor allografts in vivo and induced rapid death of cells from freshly resected human medulloblastomas, but not from other brain tumors, thus establishing a specific role for Hh pathway activity in medulloblastoma growth.
Operationalising participatory research and gender analysis: new research and assessment approaches

Participatory research approaches are increasingly popular with scientists working for poverty alleviation, sustainable rural development, and social change. This introduction offers an overview of the special issue of Development in Practice on the theme of ‘operationalising participatory research and gender analysis’. The purpose of this special issue is to add value to the discussion of methodological, practical, philosophical, political, and institutional issues involved in using gender-sensitive participatory methods. Drawing on 16 articles, we place some of the main issues, empirical experiences, and debates in participatory research and participatory technology development in the context of implementation, evaluation, and institutionalisation of participatory research and evaluation approaches.
Canadian Cyberparties: Reflections on Internet-Based Campaigning and Party Systems

Abstract. Canadian political parties have been using the Internet as a campaign tool since the 1997 election. Rebuilding Canadian Party Politics by Carty, Cross and Young (2000) presents one of the first analyses of Internet-based communications during a Canadian election. It is also one of the most important assessments of Canadian party systems. The book outlines the components that characterize the fourth party system, which they argue, began after the 1993 election. Regionalization is the defining characteristic of this emerging system. The book argues that the Internet, like other communication technologies, is important in this latest party system. Consistent with the notion of regionalized campaign communications, the authors suggest that Canadian political parties use the Internet to target campaign messages to different regional and sociodemographic groups and enter into private conversations with voters. Using original data collected from the 2004 federal election, this paper reflects on these claims. The paper builds the case that the use of the Internet as a campaign tool is not consistent with their argument. Internet-based campaign communications in Canada by the major parties is neither regionalized nor targeted. Rather, this technology makes campaign communication more transparent and centralized. Résumé. Au Canada, les partis politiques utilisent Internet comme outil de campagne depuis l'élection de 1997. Rebuilding Canadian Party Politics, par Carty, Cross et Young (2000), présente l'une des premières analyses des communications sur Internet pendant une campagne électorale. Il constitue aussi l'une des plus importantes évaluations des systèmes des partis politiques canadiens. Le livre dégage également les éléments qui caractérisent le système à quatre partis qui est né, selon eux, après l'élection de 1993. La régionalisation est la caractéristique déterminante de ce nouveau système. Le livre soutient qu'Internet, comme les autres technologies de communication, est important pour ce nouveau système à quatre partis. Conformément à la notion de communications de campagne régionalisées, les auteurs suggèrent que les partis politiques canadiens utilisent Internet pour cibler les messages de campagne selon les différents groupes régionaux et sociodémographiques et engager des conversations privées avec les électeurs. Le présent article examine ces affirmations à partir des données recueillies lors de l'élection fédérale de 2004. Il établit que l'utilisation d'Internet comme outil de campagne ne cadre pas avec leur argument. Les campagnes de communication sur Internet menées par les principaux partis au Canada ne sont ni régionalisées ni ciblées. Cette technologie rend plutôt les communications des campagnes électorales plus transparentes et plus centralisées.
A stochastic production planning model under uncertain seasonal demand and market growth

This paper proposes a stochastic production planning model for an international enclosure manufacturing company with seasonal demand and market growth uncertainty. The company purchases material and subassembly from overseas and long lead times have been observed. To prevent excess inventory and stockout, the company is required to forecast its demand and project its purchasing decisions and production load to its key suppliers in an effort to reduce risks for both parties. To assist purchasing and production decisions, a two-stage stochastic production planning model that explicitly includes uncertainty is developed with the goal of minimising the total production, inventory, and overtime costs under all scenarios. The model is solved using real data from the company and results have demonstrated the effectiveness of the model compared with various deterministic models. Parametric analyses are performed to derive managerial insights related to issues such as overtime usage, inventory holding costs and the proper selection of scenarios under pessimist, neutral, and optimist outlooks. The model has been implemented and an annual saving of more than $400,000 in inventory cost has been achieved.
Model for self-adaptive SoS and the control problem

In this paper, we propose methods to deal with self-adaptive information systems where one has to control in real time a complex substratum organized with numerous proactive elements continuously producing active links and generating multiple informational exchanges. Such exchanges arise when linking concurrent distributed complex systems. More generally, the growing complexity of today's grand challenges suits such situations and needs solutions that are of a system of systems (SoS) nature. The paper concentrates on the representation of the controlled state of the substratum for a complex adaptive SoS and highlights the control aspect.
Interaction of the fluoroquinolone antimicrobial agents ciprofloxacin and enoxacin with liposomes

The interaction between ciprofloxacin and enoxacin and phospholipid-containing bilayers was examined as the initial step in transmembrane diffusion processes. By using cosedimentation, maximal association of liposomes and 14C-labeled enoxacin and ciprofloxacin was detected at acidic and neutral pHs. Aqueous solubility of ciprofloxacin, enoxacin, and norfloxacin was poorest at neutral pH and greater at alkaline or acidic pHs. These investigations suggest that the interaction occurs because of ionic and hydrophobic forces and is nonsaturable up to 20 micrograms/ml.
Patterns of Water, Heat, and Solute Flux through Streambeds around Small Dams

Hyporheic exchange, enhanced by complex stream channel morphology, can influence biogeochemical processing in the streambed. These processes chemically alter water passing temporarily through the streambed, which eventually returns to the stream channel and can potentially affect surface water quality. To assess the degree of biogeochemical cycling induced by complex streambed morphology, we instrumented two 20‐m reaches of Red Canyon Creek, Wyoming, each containing a small log dam, with in‐stream minipiezometers and temperature data loggers. We simultaneously observed pore water geochemistry and streambed temperature dynamics in several bedforms located upstream or downstream of the dams. We modeled seepage flux into the streambed using heat transport modeling.
Safety and efficacy of Hartone in stable angina pectoris--an open comparative trial.

OBJECTIVES To evaluate the safety and efficacy of 'Hartone'--a proprietary herbal product primarily containing Terminalia arjuna in stable angina pectoris patients. PATIENTS AND METHODS Ten patients with stable angina pectoris were given Hartone 2 caps twice daily for 6 weeks and 1 cap twice daily for the next 6 weeks. Haematological and biochemical investigations to assess safety were carried out on day 0, day 42 and day 84. Serum lipid profile was done before and after therapy. Efficacy was assessed by considering the reduction in the number of anginal episodes and improvement in stress test. The results were compared with 10 patients of stable angina pectoris on isosorbide mononitrate (ISMN) 20 mg twice daily. RESULTS Hartone afforded symptomatic relief in 80% of patients and ISMN in 70%. The number of anginal attacks were reduced from 79/wk to 24/wk by Hartone and from 26/wk to 7/wk by ISMN. Although patients of both groups showed improvement in several stress test parameters compared to base line, the difference was not statistically significant. Hartone improved BP response to stress test in two patients and ejection fraction in one. Hartone was better tolerated than ISMN and showed no evidence of hepatic or renal impairment. Its effects on lipid profile was not consistent. CONCLUSION Hartone is a safe and effective anti-anginal agent comparable to ISMN and is better tolerated. Large scale, randomised, double blind trials are needed to prove its efficacy.
An Examination of Management's Regulatory Filing Choices Surrounding Restatements

ABSTRACT: A restatement suggests the existence of managerial errors and internal control weaknesses within the company. Disclosures of restatements highlight ineffective management and control systems such that management might act strategically in disclosing restatement and choose less transparent options. There are, however, external forces that likely encourage management to provide more transparent restatement disclosures, despite the fact that managerial ineffectiveness will be publicized. We examine the association between company and restatement characteristics and management's restatement filing choices to provide insight into external economic forces driving the choice. We document that more transparent filing is positively associated with the materiality of the restatement, an SEC investigation, the reporting of material internal control weaknesses, and leverage, and negatively associated with a CEO change. We also find that restatements filed via 8-Ks and via 10-K/As, after the SEC rule clarifi.
Animosity on the Home Front: The Intifada in Israel and Its Impact on Consumer Behavior

International animosity significantly affects the purchase of foreign products. However, domestic conflicts are also rampant in many countries, giving rise to similar issues. October 2000 marked the beginning of the second Arab Intifada (uprising) in Israel. In contrast to the first Intifada of the late 1980s and early 1990s, this time, Israeli Arabs joined the Palestinians in violent demonstrations in Israeli locations with large Arab concentrations. This research studies Jewish Israelis’ reactions to Arab Israelis in the context of purchases and consumption of products and services produced or marketed by Arab Israelis. It examines animosity, its antecedents, and its consumption consequences within the large Jewish majority of the population in Israel. The authors find that dogmatism, nationalism, and internationalism affect animosity, which in turn predicts willingness to buy and actual changes in purchase behavior for goods and services produced or marketed by Israeli Arabs. In contrast to previous research, animosity also predicts product judgments.
STLS/US-VECM6.1: a vector error-correction forecasting model of the U. S. economy

Any research or policy analysis exercise in economics must be consistent with the time-series properties of observed macroeconomic data. This paper discusses in detail the specification of a six-variable vector error-correction forecasting model. We test for cointegration among those variables: the CPI, the implicit price deflator for GDP, real money balances (M1), the federal funds rate, the yield on long-term (10-year) government bonds, and real GDP. We also examine the estimated dynamic parameters of the vector error correction structure, and analyze the properties of the model residuals in detail; discuss the forecasting performance of the model with particular reference to the 1990-91 recession and the 1994-95 expansion; compare alternative permanent/transitory decompositions of the data series that are implied by the estimated parameters of the model; discuss the role of weak exogeneity in our estimated structure, and the identifying restrictions that are sufficient to determine a 'historical policy rule' within the sample; discuss the conditions required for identification of 'dynamic economic models' from the reduced form VECM structure and apply one set of exactly identifying restrictions to derive impulse response functions for a permanent nominal shock and a permanent real shock; and, report some ex-ante forecasts from recent history.
Journal of Agricultural & Food Industrial Organization Social Welfare and the Market Power-Efficiency Tradeoff in U . S . Food Processing : A Note

This article computes the welfare changes from increases in industrial concentration in a sample of 35 U.S. food manufacturing industries, taking into account oligopoly power and efficiency effects. It is estimated that a 1% across-the-board increase in the Herfindahl index would lead to an increase in aggregate social welfare (with increases in 74% of the industries), nearly neutral consumer welfare effects, and increases in producer welfare due to efficiency gains that are not passed on. The results call into question the conventional wisdom that considers welfare losses from market power without considering potential gains in production efficiency.