Miracle-dz/UniFAR-FTUs huggingface dataset:
A randomized controlled trial on the efficacy of intermittent and continuous traction for patients with knee osteoarthritis

Objective: To investigate the efficacy of intermittent and continuous traction in the treatment of knee osteoarthritis. Design: A randomized, controlled, observer-blind seven-week trial. Setting: Hospital-based outpatient practice. Subjects: Ninety-eight patients with stage 3 knee osteoarthritis according to Kellgren–Lawrence radiological rating scale. Interventions: All 98 patients were randomly assigned to three treatment groups, for three weeks (weekends excluded). The control group (n=30, mean age: 59.30±8.16) received hot pack and short wave diathermy; the intermittent group (n=30, mean age: 58.20±7.78) received hot pack, short wave diathermy and intermittent traction; and the continuous group (n=30, mean age: 57.97±9.53) received hot pack, short wave diathermy and continuous traction. Outcome measurements: The values of the Turkish version of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), visual analog scale, and knee passive range of motion were measured at baseline, three-week and seven-week follow-up. Results: Compared with baseline at weeks 3 and 7, all the outcome measures, except range of motion, were significantly reduced in all groups (all P≤0.001). In terms of the change data from baseline to week 3, both traction groups were significantly superior to the control in the WOMAC physical function scores. Considering the change data from baseline to week 7, both traction groups were significantly superior to the control in the pain scores, physical function and total scores, while only the continuous group was significantly better than the control in the stiffness scores (control: 1.17 ± 1.64; continuous: 2.38 ± 1.44) (P=0.014). Compared with baseline at weeks 3 and 7, range of motion values significantly increased in both traction groups (P<0.05) but not in the control (P>0.05). However, there were no significant differences among the three groups considering the change data from baseline to week 7 in range of motion values (P=0.300). Conclusions: Joint traction was found to be beneficial for the improvement of pain and physical function loss related to knee osteoarthritis.
Quantitative Trait Loci Associated with Drought Tolerance in Brachypodium distachyon

The temperate wild grass Brachypodium distachyon (Brachypodium) serves as model system for studying turf and forage grasses. Brachypodium collections show diverse responses to drought stress, but little is known about the genetic mechanisms of drought tolerance of this species. The objective of this study was to identify quantitative trait loci (QTLs) associated with drought tolerance traits in Brachypodium. We assessed leaf fresh weight (LFW), leaf dry weight (LDW), leaf water content (LWC), leaf wilting (WT), and chlorophyll fluorescence (Fv/Fm) under well-watered and drought conditions on a recombinant inbred line (RIL) population from two parents (Bd3-1 and Bd1-1) known to differ in their drought adaptation. A linkage map of the RIL population was constructed using 467 single nucleotide polymorphism (SNP) markers obtained from genotyping-by-sequencing. The Bd3-1/Bd1-1 map spanned 1,618 cM and had an average distance of 3.5 cM between adjacent single nucleotide polymorphisms (SNPs). Twenty-six QTLs were identified in chromosome 1, 2, and 3 in two experiments, with 14 of the QTLs under well-watered conditions and 12 QTLs under drought stress. In Experiment 1, a QTL located on chromosome 2 with a peak at 182 cM appeared to simultaneously control WT, LWC, and Fv/Fm under drought stress, accounting for 11–18.7% of the phenotypic variation. Allelic diversity of candidate genes DREB2B, MYB, and SPK, which reside in one multi-QTL region, may play a role in the natural variation in whole plant drought tolerance in Brachypodium. Co-localization of QTLs for multiple drought-related traits suggest that the gene(s) involved are important regulators of drought tolerance in Brachypodium.
The Demography of Indonesia in Comparative Perspective

Having reduced its fertility rate over the past 40 years, Indonesia has reached a new demographic crossroad. Its fertility rate is now around 2.5 births per woman, which, if sustained, would add substantial numbers to Indonesia's population in the future. There are concerns within Indonesia that the present level of population growth is an obstacle to continued economic development and, accordingly, that fertility should be reduced to the replacement level of 2.1 births per woman as soon as possible. Yet a comparative perspective indicates that countries such as Singapore, Japan, and Thailand are concerned about the effects that their very low rates of fertility are having on their labour forces and their rates of population ageing. This article suggests that with the right policy settings Indonesia can avoid this outcome yet continue to reduce its fertility. It discusses the implications of Indonesia's population growth and distribution for its economy, as well as the poor quality of demographic data.
Social context, sexual risk perceptions and stigma: HIV vulnerability among male sex workers in Mombasa, Kenya

Knowledge about sexual practices and life experiences of men having sex with men in Kenya, and indeed in East Africa, is limited. Although the impact of male same-sex HIV transmission in Africa is increasingly acknowledged, HIV prevention initiatives remain focused largely on heterosexual and mother-to-child transmission. Using data from ten in-depth interviews and three focus group discussions (36 men), this analysis explores social and behavioural determinants of sexual risks among men who sell sex to men in Mombasa, Kenya. Analysis showed a range and variation of men by age and social class. First male same-sex experiences occurred for diverse reasons, including love and pleasure, as part of sexual exploration, economic exchange and coercion. Condom use is erratic and subject to common constraints, including notions of sexual interference and motivations of clients. Low knowledge compounds sexual risk taking, with a widespread belief that the risk of HIV transmission through anal sex is lower than vaginal sex. Traditional family values, stereotypes of abnormality, gender norms and cultural and religious influences underlie intense stigma and discrimination. This information is guiding development of peer education programmes and sensitisation of health providers, addressing unmet HIV prevention needs. Such changes are required throughout Eastern Africa.
The Ideal Blend of Growth and Value

Style-based investment strategies have flourished in the United States. Recently, international style-based strategies have also been increasing. In addition, many investment professionals have advocated diversified style-based portfolios, that is, portfolios holding both growth and value funds. In practice, however, it is not clear that style-based diversification works well to increase return and decrease risk. The authors' empirical analysis strongly suggests that style-based diversification in the U.S. is not ideal. They find that a well-constructed, genuinely style-neutral core portfolio will likely generate higher long-term risk-adjusted performance in the U.S. than comparable growth and value portfolios. Internationally, the results are not as clear. Although international style-based portfolios outperformed core funds, the relatively new and changing style environment, coupled with the strong growth bias of international core funds, suggests that these historical results may not be indicative of future results.
Expression of genes of Trichoderma harzianum in response to the presence of cadmium in the substrate

Trichoderma harzianum is a very important fungus for the reduction of the amount of heavy metals resulting from agricultural and industrial activities. This filamentous fungus has been shown to be tolerant towards several heavy metals (e.g. Cd, Pb, Zn, Ni and Mn), but the mechanism underlying this tolerance is not entirely understood. In this study, we confirmed the ability of T. harzianum to grow in the presence of cadmium and observed a significant stimulation of its growth in the presence of mercury. A molecular approach to investigate the cadmium tolerance mechanisms was carried out by the application of the suppression subtractive hybridisation (SSH) technique. To this end, we have used a particular strategy to discriminate cadmium-induced differentially expressed genes from those generally expressed upon heavy metal treatment. Several genes (109) were found to be overexpressed in the presence of cadmium, confirming the dramatic metabolic modification underlying the metal stress response of the fungus.
The Europeanization of interest groups: Group type, resources and policy area

Large variation exists in the extent to which national interest groups focus on European Union (EU) legislation and carry out their political activities in Brussels and Strasbourg. What explains this variation? We propose a series of hypotheses that suggest that business groups, and groups active in policy areas with high EU competence, are more Europeanized than other groups. The effect of group type, moreover, is conditional on the material resources a group possesses: we expect the difference between business and non-business groups to be largest for actors that are well endowed with material resources. Using novel data on 880 national associations, gained from a survey of interest groups in five European countries, we find support for these hypotheses. The article has implications for the literatures on lobbying, Europeanization, and theories of European integration.
Changes in the carbon cycle of Amazon ecosystems during the 2010 drought

Satellite remote sensing was combined with the NASA-CASA (Carnegie Ames Stanford Approach) carbon cycle simulation model to evaluate the impact of the 2010 drought (July through September) throughout tropical South America. Results indicated that net primary production in Amazon forest areas declined by an average of 7% in 2010 compared to 2008. This represented a loss of vegetation CO2 uptake and potential Amazon rainforest growth of nearly 0.5 Pg C in 2010. The largest overall decline in ecosystem carbon gains by land cover type was predicted for closed broadleaf forest areas of the Amazon river basin, including a large fraction of regularly flooded forest areas. Model results support the hypothesis that soil and dead wood carbon decomposition fluxes of CO2 to the atmosphere were elevated during the drought period of 2010 in periodically flooded forest areas, compared to those for forests outside the main river floodplains.
Poly-N-acetyl glucosamine fibers accelerate hemostasis in patients treated with antiplatelet drugs.

BACKGROUND Nanofibers consisting of poly-N-acetyl glucosamine (pGlcNAc), as the functional component of products for surface hemostasis, have been shown to activate platelets and thereby the clotting mechanism. The nanofiber-activated platelets provide a catalytic surface for acceleration of the intrinsic coagulation cascade, thrombin generation, and fibrin polymerization. METHODS Thromboelastographic analysis was undertaken to study the role of the pGlcNAc nanofibers in platelet activation and acceleration of fibrin polymerization. Thromboelastographic studies were performed without added activators of coagulation. RESULTS The pGlcNAc nanofibers were found to accelerate fibrin polymerization in whole blood and platelet-rich plasma. Treatment with eptifibatide (an inhibitor of the platelet GPIIbIIIa receptor) and corn trypsin inhibitor inhibited clotting of whole blood and platelet-rich plasma. The inhibition was reversed by treatment with pGlcNAc nanofibers. Inhibition was not observed after treatment with aspirin alone, MRS2359 (platelet ADP receptor inhibitor), or by a combination of aspirin and MRS2359. The pGlcNAc nanofibers accelerate clotting in normal blood treated with aspirin and MRS2359. Clopidogrel (Plavix) and aspirin did not affect the kinetics of pGlcNAc-mediated fibrin polymerization in blood from patients treated with antiplatelet drugs compared with nontreated blood. CONCLUSIONS These results provide evidence that pGlcNAc nanofibers activate platelets and accelerate the clotting of blood, and on how best to achieve surface hemostasis when patients are coagulopathic because of shock and/or to treatment with antiplatelet drugs.
Human resource management in Greece in comparative perspective: alternative institutionalist perspectives and empirical realities

This paper seeks to understand the effects of institutions on the practice of human resource management (HRM) in Greece. Hence, it evaluates how alternative approaches to institutions conceptualize contexts such as Greece, and the relevance of such approaches in the light of empirical evidence. The latter would suggest that, in common with other Mediterranean economies, Greece has been undergoing a long evolution, marked by reforms both towards greater liberalization and greater coordination. However, the ultimate direction remains unclear, and embedded ways of doing things – above all, a strongly paternalist tradition – persist. Again, as with other Mediterranean economies, the Greek economy is an essentially dualistic one, divided between larger organizations (both within the state and private sectors) and the SME sector: the relative importance of the latter has increased in recent years. Empirical research evidence would underscore the importance of conceptualizing institutions as subject to both continuity, and uneven, contested, yet constant change, and the extent to which internal diversity persists within national institutional frameworks.
Do Foreign Trade and Investment Lead to Higher CO2 Emissions? Evidence from Cross-Country Empirical Estimates

The waves of globalisation in the past decades have increased the cross-country trade and investment flows, which also raise serious concerns over environmental sustainability and climate change owing to the following three effects. First, through scale effect the growing output and exports of the polluting sectors may adversely influence environmental balance. Secondly, growing trade volume can lead to change in industry structure and output composition resulting from composition effect, which may or may not have adverse environmental repercussions. Finally, the technique effect determines the pace of improvement in emission abatement standards and regulatory policies in an economy with rise in trade orientation. The present analysis attempts to analyse the effects of trade and investment orientation with respect to a particular climate change concern, namely per capita CO2 emissions, through panel data model for a set of 181 countries over 1980–2009. The empirical findings confirm that both in case of lower and higher income countries, higher merchandise and service trade growth leads to higher per capita CO2 emission growth in their territories. In addition, both FDI inward and outward stock is found to be positively related to CO2 emission, reflecting a complementary relationship between the two. The empirical results indicate that the composition, scale and technology effects significantly influence the openness—per capita CO2 emission interrelationship across countries.
Interventional radiology in the management of the liver transplant patient

Liver transplantation (LT) is commonly used to treat patients with end‐stage liver disease. The evolution of surgical techniques, endovascular methods, and medical care has led to a progressive decrease in posttransplant morbidity and mortality. Despite these improvements, a multidisciplinary approach to each patient remains essential as the early diagnosis and treatment of the complications of transplantation influence graft and patient survival. The critical role of interventional radiology in the collaborative approach to the care of the LT patient will be reviewed. Liver Transplantation 23 1328–1341 2017 AASLD.
Motivation for Agri-Tourism Entrepreneurship

The purpose of this study was to reveal the motivations for agri-tourism entrepreneurship among Virginia farm families and to explore Weber’s theory of formal and substantive rationality as a possible theoretical framework for agritourism entrepreneurship motivation. Results of this study support the use of Weber’s theory of formal and substantive rationality as a framework for the dynamic nature of motivations for agri-tourism entrepreneurship between formal (primarily economic) reasons and substantive (primarily socio-cultural) reasons. Respondents indicated that Virginia farm families owned small farms, utilized farming as a secondary income source, and indicated their most popular agritourism activities to be pick-your-own produce, Christmas tree sales, hayrides, children’s educational programs, petting zoos, and on-farm festivals. Agri-tourism planners should be aware that acres owned, economic dependence on farming operation, and perceived popularity of agri-tourism activities are influential factors to motivate agri-tourism entrepreneurs.
The demise of total quality management (TQM)

Total quality management (TQM) was deemed by many, a decade or so ago, to be a management movement so significant that it was a paradigm change capable of completely reorienting corporate management responsibilities. It was the answer to the product quality challenge from Japan. It made quality “job number one”. TQM was to provide the interdepartmental connections and the sharing of information, goals, and responsibilities that would assure complete organizational realignment to customer needs. It sounded good and pragmatically made sense being just “too logical” not to work. So, where is it now?
CONSUMER ACCEPTANCE OF GENETICALLY MODIFIED FOODS

Results from an Ohio survey indicate that respondents are willing to pay a premium, ranging from 5% for non-GM vegetable oil to 28% for non-GM salmon. Estimated consumer willingness to pay for non-GM foods varies among demographic groups with female, those aged between 35 and 60, and non-White respondents willing to pay a higher premium than others.
Modulation of the Immune System for the Treatment of Glaucoma

Background: At present intraocular pressure (IOP) lowering therapies are the only approach to treat glaucoma. Neuroprotective strategies to protect the retinal ganglion cells (RGC) from apoptosis are lacking to date. Substantial amount of research concerning the role of the immune system in glaucoma has been performed in the recent years. This review aims to analyse changes found in the peripheral immune system, as well as selected local changes of retina immune cells in the glaucomatous retina. Methods: By dividing the immune system into the innate and the adaptive immune system, a systematic literature research was performed to find recent approaches concerning the modulation of the immune system in the context of glaucoma. Also ClinicalTrials.gov was assessed to identify studies with a translational context. Results: We found that some aspects of the immune system, such as changes in antibody levels, changes in toll like receptor signalling, T cells and retinal microglial cells, experience more research activity than other areas such as changes in dendritic cells or macrophages. Briefly, results from clinical studies revealed altered immunoreactivities against retinal and optic nerve antigens in sera and aqueous humor of glaucoma patients and point toward an autoimmune involvement in glaucomatous neurodegeneration and RGC death. IgG accumulations along with plasma cells were found localised in human glaucomatous retinae in a pro-inflammatory environment possibly maintained by microglia. Animal studies show that antibodies (e.g. anti- heat shock protein 60 and anti-myelin basic protein) elevated in glaucoma patients provoke autoaggressive RGC loss and are associated with IgG depositions and increased microglial cells. Also, studies addressing changes in T lymphocytes, macrophages but also local immune responses in the retina have been performed and also hold promising results. Conclusions: This recapitulation of recent literature demonstrates that the immune system definitely plays a role in the pathogenesis of glaucoma. Multiple changes in the peripheral innate as well as adaptive immune system have been detected and give room for further research concerning valuable therapeutic targets. We conclude that there still is a great need to bring together the results derived from basic research analysing different aspects of the immune system in glaucoma to understand the immune context of the disease. Furthermore local immune changes in the retina of glaucoma patients still leave room for further therapeutic targets
Differential expression of cytochrome oxidase (COX) genes in different regions of monkey brain

A frontal pole cDNA library from monkey (Macaca mulatta) brain was screened to identify mRNAs that are expressed more in frontal pole as compared to primary visual cortex. Three cDNA clones, whose greater expression was confirmed by Northern blot analysis, were identified as cytochrome oxidase (COX) subunits I, II, and III (COX I, II, and III). Each clone showed higher levels of mRNA in the frontal pole, dorsal lateral prefrontal cortex, and hippocampus than in the primary visual or somatosensory cortices. COX histochemistry of prefrontal, visual, and somatosensory cortical regions demonstrated heterogeneous distributions, with highest activity in dendrite‐rich neuropil of the cortex. A laminar distribution of COX mRNA expression also was demonstrated with in situ hybridization. mRNA was detected in cell bodies and in apical dendrites. These results indicate region specific differences in the distribution of COX activity and in the corresponding mRNA for three of its subunits within the monkey brain. Such differences may be related to differences in the distribution of neuropil as compared with cell bodies among the brain regions studied, and may be relevant to selective vulnerability in Alzheimer's disease. Published 1992 by Wiley‐Liss, Inc. © 1992 Wiley‐Liss, Inc.
Estimating Cost of Capital in Firm Valuations with Arithmetic or Geometric Mean - Or Better Use the Cooper Estimator?

We test the extent and determinants of bias effects of the arithmetic as well as the geometric mean estimator and the estimator of Cooper [1996. Arithmetic versus geometric mean estimators: Setting discount rates for capital budgeting. European Financial Management 2 (July): 157-67] regarding discount rate estimation for firm valuation by way of a bootstrap approach for 13 different countries. The Cooper estimator is superior to both the geometric and the (conventional) arithmetic mean estimator. However, a 'truncated' version of the arithmetic mean estimator leads generally to better estimation outcomes than the Cooper estimator. This means that, in order to reduce problems of upward-biased firm value estimates, expected cash flows beyond a certain time horizon are completely neglected in terminal value estimation. Such an approach seems particularly reasonable for the valuation of young growth companies as well as for companies from quickly developing countries such as Brazil, China, or Thailand, because the bias in terminal value estimation is increasing in the growth rate of future expected cash flows.