Miracle-dz/UniFAR-FTUs huggingface dataset:
Age-Modulated Immuno-Metabolic Proteome Profiles of Deceased Donor 3 Kidneys Predict 12-Month Posttransplant Outcome 4

32 Background . Organ availability limits kidney transplantation, the best treatment for end-33 stage kidney disease. Deceased donor acceptance criteria have been relaxed to include older 34 donors with higher risk of inferior posttransplant outcomes. Donor age, although significantly 35 correlates with transplant outcomes, lacks granularity in predicting graft dysfunction. Better 36 characterization of the biological mechanisms associated with deceased donor organ damage and 37 specifically predictive of transplant outcome in recipients is key to developing new assessment 38 criteria for donor kidneys and developing function-preserving interventions. 39 Methods. 185 deceased donor pretransplant biopsies with clinical and demographic 40 donor and recipient metadata were obtained from the Quality in Organ Donation biobank 41 (QUOD), selected on the basis of 12-month paired posttransplant function and deep proteomic 42 profiles acquired by mass spectrometry. Using a 2/3 rd :1/3 rd training:test data split, sampling 43 equally across posttransplant function, we applied machine learning feature selection followed 44 by protein-wise relaxed LASSO regression modeling, assessing the performance of the final set 45 of protein models on the test data. Western blotting validated protein changes, and the biological 46 relevance of the final set of protein models was externally validated by contextualization against 47 a published dataset of human healthy and disease kidney transcriptomes. 48 Results. Our analysis revealed 144 proteins carrying outcome-predictive information, all 49 of which showed donor-age modulated associations with posttransplant function, as opposed to 50 age and protein/gene effects being independent terms. Observed associations with inflammatory, 51 metabolic, protein processing and cell cycle pathways suggest biological targets for possible 52 interventions pretransplant. Contextualization of our results against external spatial 53 transcriptomic data suggest a sub-nephrotic spatial localization of the predictive signal. 54
The Raw Microprocessor: A Computational Fabric for Software Circuits and General-Purpose Programs

Wire delay is emerging as the natural limiter to microprocessor scalability. A new architectural approach could solve this problem, as well as deliver unprecedented performance, energy efficiency and cost effectiveness. The Raw microprocessor research prototype uses a scalable instruction set architecture to attack the emerging wire-delay problem by providing a parallel, software interface to the gate, wire and pin resources of the chip. An architecture that has direct, first-class analogs to all of these physical resources will ultimately let programmers achieve the maximum amount of performance and energy efficiency in the face of wire delay.
Design, Reliability Investigation and Analysis of 60 GHz band LNA in 65nm CMOS for 5G Mobile Communication

A LNA has been designed in Cadence simulator in 60 GHz band (57-64 GHz) in 65nm CMOS with microstrip as on-chip inductors. LNA has gain of 11.55 dB at 60 GHz. The noise figure is 4.98 dB at 60 GHz. The 3-dB bandwidth for this LNA design is 57-64 GHz. The stability factor (K) is greater than 1 for the entire range. Additionally, the 1-dB gain compression point (P1dB) is −10.0229 dBm and the IIP3 value is −2.2 dBm at 60 GHz. PVT (Process-Voltage-Temperature) simulations is also done for reliability investigation and analysis where the performance of LNA is tested under various process corners, temperatures and voltages. Gain of the amplifier was observed under different process corners, temperatures (from −40°C to 100°C) and voltages. It was observed that the amplifier’s gain was invariant in the voltage variation range of 1 - 1.4 V. Moreover, we observed that the higher peak in the gain graph is due to the fast-fast process corner parameter and the lower peak is due to the slow-slow process corner parameter. The highest peak gain was observed for the Fast-Fast process corner and at low temperature of −40°C and lowest peak gain for Slow-Slow process corner and at high temperature of 100°C. FoM (figure of merit) is 0.92 GHz/mW at 60 GHz. Hence a reliable design of LNA is achieved for the 60 GHz band for 5G mobile communication application.
Cretaceous-Tertiary evolution of the western Coast Mountains, central southeastern Alaska

The Coast Mountains orogen in central southeastern Alaska records intra-arc mid-Cretaceous underthrusting of the Alexander terrane and Gravina belt beneath metamorphic rocks correlative with the Yukon-Tanana terrane followed by evolution of the Late Cretaceous and early Tertiary Coast shear zone. U-Pb geochronologic data from the Bradfield Canal and Stikine River regions demonstrate that arc-related plutonism continued from mid-Cretaceous to Eocene time, synchronous with deformational evolution of the orogen. The southwest-vergent mid-Cretaceous Sumdum fault separates the Gravina belt from the Yukon-Tanana terrane, which in this region is dominated by a Middle to Late Devonian arc assemblage. Mid-Cretaceous plutons that crosscut this structure suggest that juxtaposition of the Yukon-Tanana terrane and Gravina belt occurred prior to ca. 90 Ma. Structures related to mid-Cretaceous contraction and pluton emplacement are truncated and overprinted by the Coast shear zone along the western flank of the Coast Mountains. Complex domainal kinematic relationships associated with ductile fabrics of the shear zone indicate a complex and protracted west- and east-side-up and possible dextral strike-slip displacement history. Simple geometric considerations and kinematic observations support a model in which this structure accommodated buoyancy-driven Late Cretaceous exhumation of the underthrust Alexander terrane followed by Paleocene-Eocene exhumation of rocks within the Coast Mountains. This younger exhumation was synchronous with tonalite and granodiorite pluton emplacement within and east of the shear zone. Limited kinematic data support a strike-slip origin for the shear zone. The shear zone likely evolved between 80 and 85 Ma and deformation continued at least through 57 Ma but ceased prior to 50 Ma.
I NDUSTRIAL M ATHEMATICS I NSTITUTE

The bipartite crossing number problem is studied, and a connection between this problem and the linear arrangement problem is established. It is shown that when the arboricity is close to the minimum degree and the graph is not too sparse, then the optimal number of crossings has the same order of magnitude as the optimal arrangement value times the arboricity. The application of the results to a tree provides for a closed formula which expresses exactly, the optimal number of crossings in terms of the optimal value of the linear arrangement and the degree sequence, resulting in an O ( n 1 . 6 ) time algorithm for computing the bipartite crossing number. Two polynomial time approximation algorithms for computing the bipartite crossing number are derived, with approximation factors, O (log 2 n ), and O (log n log log n ), from the optimal, respectively, for approximating the number of crossings, and at the same time, total edge lengths, for a large class of graphs on n vertices. No approximation algorithm which could generate a provably good solution was previously known. The problem of computing a largest weighted biplanar subgraph of an acyclic graph is also studied and a linear time algorithm for it is derived. This problem was known to be NP-hard when the graph is planar and very sparse, and all weights are 1.
Did Antarctic sea‐ice expansion cause glacial CO2 decline?

Recently, Stephens and Keeling [2000] have put forward an appealing theory for explaining the decrease in glacial atmospheric CO2. They argue that a compact sea‐ice cover extending southward of ∼55° S trapped large amounts of CO2 beneath the sea surface, thus accounting for the lower atmospheric concentrations. An atmosphere‐ocean box model in which sea‐ice area is prescribed allows them to simulate ∼80% of the CO2 drawdown. However, glacial CO2 levels can be attained in their model only when the fraction of ice‐covered area southward of the Antarctic Polar Front rises to 99–100%. We present simulations with a coupled sea ice‐upper ocean model indicating that ice‐area fractions so large might have not prevailed even under rather extreme glacial conditions. The combination of our glacial ice‐coverage estimates with the ice area‐CO2 relation derived by Stephens and Keeling suggests that CO2 sequestration under sea ice could account for at most 15–50% of the total glacial CO2 decline.
2021). OmpF Downregulation Mediated by Sigma E or OmpR Activation Confers Cefalexin Resistance in Escherichia coli in the Absence of Acquired β-Lactamases. Antimicrobial Agents and Chemotherapy

Cefalexin is a widely used 1 st generation cephalosporin, and resistance in Escherichia coli is caused by Extended-Spectrum (e.g., CTX-M) and AmpC β-lactamase production and therefore frequently coincides with 3 rd generation cephalosporin resistance. However, we have recently identified large numbers of E. coli isolates from human infections, and from cattle, where cefalexin resistance is not β-lactamase mediated. Here we show, by studying laboratory selected mutants, clinical isolates, and isolates from cattle, that OmpF porin disruption or downregulation is a major cause of cefalexin resistance in E. coli . Importantly, we identify multiple regulatory mutations that cause OmpF downregulation. In addition to mutation of ompR , already known to downregulate OmpF and OmpC porin production, we find that rseA mutation, which strongly activates the Sigma E regulon, greatly increasing DegP production, which degrades OmpF, OmpC and OmpA. Furthermore, we reveal that mutations affecting lipopolysaccharide structure, exemplified by the loss of GmhB, essential for lipopolysaccharide heptosylation, also modestly activate DegP production, resulting in OmpF degradation. Remarkably, given the critical importance attached to such systems for normal E. coli physiology, we find evidence for DegP-mediated OmpF downregulation, gmhB and rseA loss of function mutation in E. coli isolates derived from human infections. Finally, we show that these regulatory mutations enhance the ability of group 1 CTX-M β-lactamase to confer reduced carbapenem susceptibility, particularly those mutations that cause OmpC in addition to OmpF downregulation.
A New Species of Small Acritarch with a Porous Wall Structure from the Early Cambrian of Estonia and Implications for the Fossil Record of Eukaryotic Picoplankton

The Proterozoic—Phanerozoic transition recorded a general trend of decrease in phytoplankton cell size, in contrast to the earlier and much larger Ediacaran acritarchs. Particularly minute, unornamented but sculptured organicwalled microfossils have been recovered from the lower Cambrian Lükati Formation in northern Estonia. The lack of any significant thermal alteration in this formation allowed for excellent preservation of fine microstructures on these microfossils. Among the rich palynomorph assemblages in the Lükati Formation, a new species of tiny, spheroidal eukaryotic microfossil is recorded: Reticella corrugata gen. et sp. nov. It is characterised by a corrugated and flexible vesicle wall that is densely perforated by nano-scale pores. Despite its unique morphology, the new species shares diagnostic characters with fossil and extant prasinophyte algae. Reticella corrugata is among the smallest microfossils with typical eukaryotic morphology (conspicuous wall sculpture) and contributes to the diversity of the size class of small acritarchs. Size, abundance, inferred prasinophyte affinity and eukaryotic wall sculpture make this new taxon a likely member of the early eukaryotic picoplankton.
Variability of the Tropical Atlantic Ocean Simulated by a General Circulation Model with Two Different Mixed-Layer Physics

Abstract The embedment of a 1.5 turbulence closure model in an ocean general circulation model of the equatorial Atlantic is presented. The eddy viscosity and diffusivity involved in the vertical mixing are defined as the product of a characteristic turbulent velocity—the root square of the turbulent kinetic energy—and a characteristic mixing length. The turbulent kinetic energy is defined through a prognostic equation while the turbulent length scales are defined by a diagnostic formulation. The results of an experiment that includes this closure scheme are compared to the results issued from another experiment that includes a Richardson number-dependent parameterization of the mixing coefficients. The two simulations were performed over the tropical Atlantic during the 1982–1984 period, which allows direct comparisons with data from the FOCAL and SEQUAL experiments. Obvious contrasts between the two experiments on the sea surface temperature and on the dynamics indicate that the turbulent vertical diffu.
Precipitation Variations in the Eastern Part of the Hexi Corridor During AD 1765–2010 Reveal Changing Precipitation Signal in Gansu

ABSTRACT We reconstructed August–May precipitation from AD 1765 to 2010 for the eastern part of the Hexi Corridor, northwest China, using tree rings of Picea crassifolia. The precipitation reconstruction explains 44.1% of the actual precipitation variance during the common period of 1951–2010. The precipitation reconstruction is representative of precipitation conditions over a large area of the Hexi Corridor. Multi-taper spectral analysis reveals the existence of significant variability with periods of 9.3, 6.7, 3.1, and 2.6 years. Comparison between the precipitation reconstruction of the eastern part of the Hexi Corridor and other nearby precipitation/drought reconstructions shows high coherency in the timing of dry/wet episodes on annual to decadal scale. The divergences existing between the reconstructions may reflect the influence of different geographic features in Gansu and differences in seasonality of the various precipitation/drought reconstructions.
GPU point list generation through histogram pyramids

Image Pyramids are frequently used in porting non-local algorithms to graphics hardware. A Histogram pyramid (short: HistoPyramid), a special version of image pyramid, sums up the number of active entries in a 2D image hierarchically. We show how a HistoPyramid can be utilized as an implicit indexing data structure, allowing us to convert a sparse matrix into a coordinate list of active cell entries (a point list) on graphics hardware. The algorithm reduces a highly sparse matrix with N elements to a list of its M active entries in O(N) + M (log N) steps, despite the restricted graphics hardware architecture. Applications are numerous, including feature detection, pixel classification and binning, conversion of 3D volumes to particle clouds and sparse matrix compression.
DEFORMATIONS OF CONCRETE MEMBERS AT YIELDING AND ULTIMATE UNDER MONOTONIC OR CYCLIC LOADING (INCLUDING REPAIRED AND RETROFITTED MEMBERS)

iii 1 Introduction 1 2 Deformations at flexural yielding of members with continuous bars 5 2.1 Uniaxial yield moment and curvature of section with rectangular, Tor Lcompression zone 5 2.2 Fixed-end rotation due to pull-out of longitudinal bars from their anchorage beyond the end section at uniaxial yielding 10 2.3 Chord rotation and secant stiffness to yield point in uniaxial flexure for members of rectangular, T-, H-, U-, or hollow rectangular section 11 2.4 Yield moment, chord rotation and secant stiffness to yield point under biaxial flexure 15 3 Effect of lap-splicing of longitudinal bars in the plastic hinge zone on member flexure-controlled yielding and secant stiffness to yield point 17 3.1 Yield moment and curvature of section with rectangular, Tor Lcompression zone 17 3.2 Chord rotation and effective stiffness at yielding 20 4 Flexure-controlled ultimate deformations of members with continuous bars 23 4.1 Uniaxial ultimate curvature of members with rectangular compression zone 23 4.2 Strains of steel and concrete at section ultimate curvature 27 4.3 Fixed-end rotation due to pull-out of longitudinal bars from their anchorage beyond the end section at member flexural failure 30 4.4 Uniaxial ultimate chord rotation from curvatures and the plastic hinge length 31 4.5 Empirical uniaxial ultimate chord rotation 32 4.6 Flexure-controlled ultimate chord rotations in biaxial loading 37 5 Effect of lap-splicing of longitudinal bars in the plastic hinge zone on flexure-controlled ultimate deformations 38 6 Shear Strength after Flexural Yielding 42 6.1 Introduction 42 6.2 Models of shear resistance in diagonal tension under inelastic cyclic deformations after flexural yielding 43 7 RC-jacketing of columns 46 7.1 Introduction 46 7.2 Simple rules for the strength, the stiffness and the deformation capacity of jacketed members 46 8 FRP-jacketing of columns 52 8.1 Seismic retrofitting with FRPs 52 8.2 FRP-wrapped columns with continuous vertical bars 52 8.2.1 Yield moment and effective stiffness to yield point 52
Methods for Bayesian inversion of seismic data

The purpose of Bayesian seismic inversion is to combine information derived from seismic data and prior geological knowledge to determine a posterior probability distribution over parameters describing the elastic and geological properties of the subsurface. Typically the subsurface is modelled by a cellular grid model containing thousands or millions of cells within which these parameters are to be determined. Thus such inversions are computationally expensive due to the size of the parameter space (being proportional to the number of grid cells) over which the posterior is to be determined. Therefore, in practice approximations to Bayesian seismic inversion must be considered. A particular, existing approximate workflow is described in this thesis: the so-called two-stage inversion method explicitly splits the inversion problem into elastic and geological inversion stages. These two stages sequentially estimate the elastic parameters given the seismic data, and then the geological parameters given the elastic parameter estimates, respectively. In this thesis a number of methodologies are developed which enhance the accuracy of this approximate workflow. To reduce computational cost, existing elastic inversion methods often incorporate only simplified prior information about the elastic parameters. Thus a method is introduced which transforms such results, obtained using prior information specified using only two-point geostatistics, into new estimates containing sophisticated multi-point geostatistical prior information. The method uses a so-called deep neural network, trained using only synthetic instances (or ‘examples’) of these two estimates, to apply this transformation. The method is shown to improve the resolution and accuracy (by comparison to well measurements) of elastic parameter estimates determined for a real hydrocarbon reservoir. It has been shown previously that so-called mixture density network (MDN) inversion can be used to solve geological inversion analytically (and thus very rapidly
Software System Design of Quad-rotor Aircraft Based on STM32F103

At first, the function of the software system of the quad-rotor aircraft is expounded. Secondly, the design scheme of the software system of the quad-rotor aircraft is introduced. Thirdly, the program design methods of the main function, the initialization of each module, the attitude information collecting of the aircraft, the information processing of the aircraft and the motor control module are emphasized. Combined with the design results of each module, the complete software system of the quad-rotor aircraft was obtained. Through repeated debugging, the aircraft can collect its own attitude information in real time and accurately, move or hover according to the preset motion planning. The debugging results show that the aircraft is flexible in control and stable in operation. The design achieves the desired goal.
Toxicological Benchmarks for Screening Potential Contaminants of Concern for Effects on Sediment-Associated Biota

A hazardous waste site may contain hundreds of chemicals; therefore, it is important to screen contaminants of potential concern for the ecological risk assessment. Often this screening is done as part of a screening assessment, the purpose of which is to evaluate the available data, identify data gaps, and screen contaminants of potential concern. Screening may be accomplished by using a set of toxicological benchmarks. These benchmarks are helpful in determining whether contaminants warrant further assessment or are at a level that requires no further attention. If a chemical concentration or the reported detection limit exceeds a proposed lower benchmark, further analysis is needed to determine the hazards posed by that chemical. If, however, the chemical concentration falls below the lower benchmark value, the chemical may be eliminated from further study. The use of multiple benchmarks is recommended for screening chemicals of concern in sediments. Integrative benchmarks developed for the National Oceanic and Atmospheric Administration and the Florida Department of Environmental Protection are included for inorganic and organic chemicals. Equilibrium partitioning benchmarks are included for screening nonionic organic chemicals. Freshwater sediment effect concentrations developed as part of the U.S. Environmental Protection Agency's (EPA's) Assessment and Remediation of Contaminated Sediment Project are included for inorganic and organic chemicals (EPA 1996). Field survey benchmarks developed for the Ontario Ministry of the Environment are included for inorganic and organic chemicals. In addition, EPA-proposed sediment quality criteria are included along with screening values from EPA Region IV and Ecotox Threshold values from the EPA Office of Solid Waste and Emergency Response. Pore water analysis is recommended for ionic organic compounds; comparisons are then made against water quality benchmarks. This report is an update of three prior reports (Jones et al. 1997; Jones et al. 1996; and Hull and Suter 1994). It contains new benchmarks for freshwater sediments, equilibrium partitioning benchmarks corrected to two significant figures, and all of the freshwater and estuarine benchmarks included in the previous version.
I NDUSTRIAL M ATHEMATICS I NSTITUTE

We present a construction of anisotropic multiresolution and anisotropic wavelet frames based on multilevel ellipsoid covers (dilations) of R n . The wavelets we construct are C ∞ functions, can have any prescribed number of vanishing moments and fast decay with respect to the anisotropic quasi-distance induced by the cover. The dual wavelets are also C ∞ , with the same number of vanishing moments, but with only mild decay with respect to the quasi-distance. An alternative construction yields a meshless frame whose elements do not have vanishing moments, but do have fast anisotropic decay.