Miracle-dz/UniFAR-FTUs huggingface dataset:
Location Aware Keyword Query Suggestion Based on Document Proximity

Keyword suggestion in web search helps users to access relevant information without having to know how to precisely express their queries. Existing keyword suggestion techniques do not consider the locations of the users and the query results; i.e., the spatial proximity of a user to the retrieved results is not taken as a factor in the recommendation. However, the relevance of search results in many applications (e.g., location-based services) is known to be correlated with their spatial proximity to the query issuer. In this paper, we design a location-aware keyword query suggestion framework. We propose a weighted keyword-document graph, which captures both the semantic relevance between keyword queries and the spatial distance between the resulting documents and the user location. The graph is browsed in a random-walk-with-restart fashion, to select the keyword queries with the highest scores as suggestions. To make our framework scalable, we propose a partition-based approach that outperforms the baseline algorithm by up to an order of magnitude. The appropriateness of our framework and the performance of the algorithms are evaluated using real data.
LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson’s Disease, Where Do We Stand?

One of the most promising therapeutic targets for potential diseasemodifying treatment of Parkinson’s disease (PD) is leucine-rich repeat kinase 2 (LRRK2). Specifically, targeting LRRK2’s kinase function has generated a lot of interest from both industry and academia. This work has yielded several published studies showing the feasibility of developing potent, selective and brain permeable LRRK2 kinase inhibitors. The availability of these experimental drugs is contributing to filling in the gaps in our knowledge on the safety and efficacy of LRRK2 kinase inhibition. Recent studies of LRRK2 kinase inhibition in preclinical models point to potential undesired effects in peripheral tissues such as lung and kidney. Also, while strategies are now emerging to measure target engagement of LRRK2 inhibitors, there remains an important need to expand efficacy studies in preclinical models of progressive PD. Future work in the LRRK2 inhibition field must therefore be directed towards developing molecules and treatment regimens which demonstrate efficacy in mammalian models of disease in conditions where safety liabilities are reduced to a minimum.
IQ-Paths: Self-regulating Data Streams across Network Overlays

Overlay networks have been shown useful for improving the delivery of network and processing resources to applications, in part due to their ability to use alternate or parallel network paths and computational resources. This paper presents IQ-Paths, a set of techniques and their middleware realization that implement self-regulating data streams for dataintensive distributed applications. Self-regulation is based on (1) the dynamic and continuous assessment of the quality of each overlay path, (2) the use of online network monitoring and statistical analyses that provide probabilistic guarantees about available path bandwidth, loss rate, and RTT, and (3) a packet routing and scheduling algorithm that dynamically schedules data packets to different overlay paths in accordance with their available bandwidths. Additional aspects of IQ-Paths are its predictive statistical bandwidth guarantees and the fact that packet scheduling across different overlay paths is governed by application-level specifications of stream utility. An example is to send control data across links that offer strong guarantees for future bandwidth vs. mapping other data across less guaranteed paths. Experimental results presented in this paper use IQ-Paths to better handle the different kinds of data produced by (1) distributed multimedia applications with desired QoS guarantees and (2) data-driven or interactive high performance codes with user-defined utility requirements.
Auxin metabolism and homeostasis during plant development

Auxin plays important roles during the entire life span of a plant. This small organic acid influences cell division, cell elongation and cell differentiation, and has great impact on the final shape and function of cells and tissues in all higher plants. Auxin metabolism is not well understood but recent discoveries, reviewed here, have started to shed light on the processes that regulate the synthesis and degradation of this important plant hormone.
Discrete time approximation of fully nonlinear HJB equations via BSDEs with nonpositive jumps

We propose a new probabilistic numerical scheme for fully nonlinear equation of Hamilton-Jacobi-Bellman (HJB) type associated to stochastic control problem, which is based on the Feynman-Kac representation in [12] by means of control randomization and backward stochastic differential equation with nonpositive jumps. We study a discrete time approximation for the minimal solution to this class of BSDE when the time step goes to zero, which provides both an approximation for the value function and for an optimal control in feedback form. We obtained a convergence rate without any ellipticity condition on the controlled diffusion coefficient. Explicit implementable scheme based on Monte-Carlo simulations and empirical regressions, associated error analysis, and numerical experiments are performed in the companion paper [13].
Target-specific membrane potential dynamics of neocortical projection neurons during goal-directed behavior

Goal-directed behavior involves distributed neuronal circuits in the mammalian brain, including diverse regions of neocortex. However, the cellular basis of long-range cortico-cortical signaling during goal-directed behavior is poorly understood. Here, we recorded membrane potential of excitatory layer 2/3 pyramidal neurons in primary somatosensory barrel cortex (S1) projecting to either primary motor cortex (M1) or secondary somatosensory cortex (S2) during a whisker detection task, in which thirsty mice learn to lick for water reward in response to a whisker deflection. Whisker stimulation in ‘Good performer’ mice, but not ‘Naive’ mice, evoked long-lasting biphasic depolarization correlated with task performance in S2-projecting (S2-p) neurons, but not M1-projecting (M1-p) neurons. Furthermore, S2-p neurons, but not M1-p neurons, became excited during spontaneous unrewarded licking in ‘Good performer’ mice, but not in ‘Naive’ mice. Thus, a learning-induced, projection-specific signal from S1 to S2 may contribute to goal-directed sensorimotor transformation of whisker sensation into licking motor output. DOI: http://dx.doi. org/10.7554/eLife.15798. 001
Electromagnetically Transparent Feed Networks for Antenna Arrays

Multiple antennas underneath a single radome are attractive for platforms with limited space. Blockage scenarios are created when multiple antennas operate under a single radome. To avoid blockage, antennas that are electromagnetically transparent at frequencies outside of their respective radiating bandwidth are required. Although a number of structures in an antenna can contribute to the blockage, this study focuses on the feed networks. Electromagnetic simulations are used to examine the scattering behavior of the feed networks obstructing a radiating source. Corporate feed network examples are investigated and were found to have poor transparency below the design frequency(Tθ,φ < −1 dB for f < 1.3f0) . Feed networks designs are presented with the aim of electromagnetic transparency. Some designs provide unequal phase to a circularly polarized antenna array and rely on a far eld phase matching method. This method rotates each array element according to the prior calculated phase output. The pseudo-random orientation of the array elements results in an improved antenna array radiating axial ratio (AR = -2.18 to -1). Right hand circularly polarized (RHCP) radiation is preserved when blocked by these feed networks. Feed networks have been designed using optimization methods and classical design techniques. A feed network incorporating several of these techniques has been built and measured for L and S band antenna arrays in a multi-band antenna system. The ii L band array blocks the S band array line of sight under certain pointing angles. An X band antenna is positioned underneath the L and S band antennas. The L band array attenuates the peak gain of the S band array but preserves the beamwidth. This attenuation is limited to the main beam and results in the sidelobe levels increasing with respect to the main beam under blockage. These antenna arrays yield RHCP radiation with an axial ratio better than -1.3 over the operating bandwidth and half power beamwidth, regardless of blockage conditions. The L and S band antennas provide approximately 1 dB of attenuation at X band while preserving the RHCP polarization.
Nutritive value of cereals in feeds for common carp ( Cyprinus carpio

Four isonitrogenous (gross protein content 32%) and isoenergetic (gross energy content 4 080 kcal/kg) diets were prepared by extrusion to investigate the effects of different cereal grains (barley – diet A, wheat – diet B, triticale – diet C, rye – diet D) as carbohydrate compounds of extruded feeds for carp. The physical and chemical properties of the feeds were established. A 60-day growth test was performed in experimental ponds of 40m2 area. Each diet was fed to three groups of fish (initial average weight 200 ± 10 g). The following rearing effectiveness indices were used in the final evaluation of the growth test: weight gain (WG, %), specific growth rate (SGR, %/d), food conversion ratio (FCR), protein efficiency ratio (PER) and protein retention (PR, %). Conclusions were based on statistical analysis using the Statistica 5.0 package. The results obtained in the growth test did not show any differences in the evaluated feeds regarding their usefulness in the nutrition of carp (there were no statistically significant differences in the values of fish rearing parameters, P ≤ 0.05). The recorded growth parameters of carp were as follows: WG: 308.48–324.0%; SGR: 2.81–2.92%/d; the feed conversion coefficients were: FCR: 1.43–1.50; PER: 1.75–1.83; PR: 29.54–31.72%.
Evaluation of no-reflow phenomenon using 201TlCl/123I-BMIPP dual-isotope myocardial SPECT.

OBJECTIVES We assessed the usefulness of (201)thallous chloride (TlCl)/(123)I-beta-methyl iodophenyl pentadecanoic acid (BMIPP) dual-isotope single-photon emission computed tomography (SPECT) to identify the "no-reflow phenomenon," defined as inadequate myocardial perfusion through a given segment of the coronary circulation without angiographic evidence of mechanical vessel obstruction. METHODS (201)TlCl/(123)I-BMIPP SPECT was performed in 73 patients within approximately 1 week of initial acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). We divided the left ventricular myocardium into 17 segments on each SPECT image and scored tracer accumulation in each segment with a five-point scoring system according to the American Heart Association criteria. Total severity scores were calculated by summing the scores for all 17 segments. The mismatch ratio between myocardial perfusion and metabolism was derived from the (201)TlCl and (123)I-BMIPP total severity scores: mismatch ratio=((123)I-BMIPP total severity score -(201)TlCl total severity score)/(123)I-BMIPP total severity score. Patients were classified according to Thrombolysis in Myocardial Infarction (TIMI) flow grade as having TIMI reflow grade 0-I (TIMI 0-I reflow group; n=11), II (TIMI II reflow group; n=17) and III (TIMI III reflow group; n=45). The TIMI III reflow group was subdivided into two groups with (201)TlCl total severity scores of < or =13 (TIMI III (A) reflow group; n=36) and > or =14 (TIMI III (B) reflow group; n=9), respectively. RESULTS The mismatch ratios in the TIMI II (0.4 +/- 0.3) and TIMI III (0.4 +/- 0.2) reflow groups were significantly higher than that in the TIMI 0-1 reflow group (0.1 +/- 0.1, p<0.05). Although coronary angiography revealed TIMI III flow after reperfusion, the mismatch ratios in the TIMI III (B) reflow group (0.2 +/- 0.1) and in the TIMI 0-I reflow group (0.1 +/- 0.1) were significantly lower than that in the TIMI III (A) reflow group (0.4 +/- 0.2, p<0.01), reflecting noneffective recanalization (so called no-reflow phenomenon). CONCLUSION (201)TlCl/(123)I-BMIPP dual-isotope myocardial SPECT reveals the biochemical degree of the no-reflow phenomenon, whereas coronary angiography shows recanalized vascular flow only. Dual-isotope myocardial SPECT might be useful for evaluating reperfusion therapy.
A Comprehensive Review of Hypertension in Pregnancy

Hypertension is the most common medical disorder encountered during pregnancy. Hypertensive disorders are one of the major causes of pregnancy-related maternal deaths in the United States. We will present a comprehensive update of the literature pertinent to hypertension in pregnancy. The paper begins by defining and classifying hypertensive disorders in pregnancy. The normal vascular and renal physiological changes which occur during pregnancy are detailed. We will summarize the intriguing aspects of pathophysiology of preeclampsia, emphasizing on recent advances in this field. The existing diagnostic tools and the tests which have been proposed for screening preeclampsia are comprehensively described. We also highlight the short- and long-term implications of preeclampsia. Finally, we review the current management guidelines, goals of treatment and describe the potential risks and benefits associated with various antihypertensive drug classes. Preeclampsia still remains an enigma, and the present management focuses on monitoring and treatment of its manifestations. We are hopeful that this in depth critique will stimulate the blossoming research in the field and assist practitioners to identify women at risk and more effectively treat affected individuals.
Simulation and Effectiveness Analysis of Jamming on Inverse Synthetic Aperture Radar

nverse synthetic aperture radar (ISAR) is a kind of imaging radar with high capability. It plays an important role in military applications, such as target classification, recognition, identification and accurate weapon navigation. This paper establishes a simulation model of jamming for ISAR system based on the principle of ISAR imaging. Then, the several typical of noise modulation jamming experiments for ISAR are carried out. The simulation results are analysed through evaluating the jamming effect based on the entropy concept.
Warm-Hot Intergalactic Medium Associated with the Coma Cluster

Hydrodynamic simulations predict that low-redshift baryons are predominantly in a warm-hot intergalactic medium (WHIM), which should exhibit absorption and emission lines in the soft X-ray region. The WHIM is predicted to be most dense around clusters of galaxies. We present our XMM-Newton RGS observations of X Comae, an active galactic nucleus behind the Coma Cluster. We detect absorption by Ne IX and O VIII at the redshift of Coma with an equivalent width of 3.3 ± 1.8 and 1.7 ± 1.3 eV, respectively (90% confidence errors or 2.3 and 1.9 σ confidence detections determined from Monte Carlo simulations). The combined significance of both lines is 3.0 σ, again determined from Monte Carlo simulations. The same observation yields a high-statistics EPIC spectrum of the Coma Cluster gas at the position of X Com. We detect emission by Ne IX with a flux of (2.5 ± 1.2) × 10-8 photons cm-2 s-1 arcmin-2 (90% confidence errors or 3.4 σ confidence detection). These data permit a number of diagnostics to determine the properties of the material causing the absorption and producing the emission. Although a wide range of properties are permitted, values near the midpoint of the range are temperature ~4 × 106 K, density ~6 × 10-6 cm-3 corresponding to an overdensity with respect to the mean of ~32, and line-of-sight path length through it ~41(Z/Z☉)-1 Mpc, where (Z/Z☉) is the neon metallicity relative to solar. These are properties that have been predicted of the WHIM, so we conclude that we have detected the WHIM associated with the Coma Cluster.
Low-cycle fatigue of surgical cements

Purpose: In case when surgical cement is used to fix endoprostheses of joints the fatigue character of mechanical interraction in the cement seems to be a significant importance. The paper suggests to adapt the research method of low cycle fatigue for modelling the loads on surgical cements in an artificial hip joint. Surgical cements have also been modified in order to improve their functional properties. Design/methodology/approach: Low cycle fatigue tests were conducted on samples made from Palamed cement without an addition and on samples modified with glassy carbon and titanium. The tests were conducted on a servohydraulic fatigue testing machine, MTS-810, with displacement control. Findings: Fatigue tests proved viscoelastic character of all the tested materials. During the fatigue tests, the phenomenon of stress cyclic relaxation was observed. Research limitations/implications: Modelling the loadings of cement in endoprostheses of joints with the low cycle fatigue method takes into account all high value stresses, while cement is being used for endoprostheses for many years in the conditions of random stress and deformation courses. Therefore the obtained stress and deformation values are bigger than those which would have been obtained in real conditions in the same time. Practical implications: The low cycle fatigue tests carried out showed how important is the factor of time for the behavior of surgical cement in the conditions of changeable loadings. This fact is essential to assess its usability for endoprosthesoplasty of joints, specially of a hip joint. Post deformation return which is a characteristic feature for material viscoelasticity enables its regeneration conditioning expected durability of endoprosthesis of joints. Originality/value: Low cycle fatigue testing method for modelling of loads on surgical cement in artificial hip joint enables to carry out the tests in a shorter period of time.
Microstructure and Mechanical Properties a New Iron-Base Material Used for the Fabrication of Sintered Diamond Tools

The main objective of the present work is to characterise the microstructure and mechanical properties of a new iron-base material which has been recently gaining ground in the manufacture of diamond impregnated tools as an economical substitute for cobalt and cobalt alloys. Its density, hardness and yield test properties have been directly compared to those of hot pressed Cobalt Extra Fine (CoEF) powder. It has been shown that the raw iron-663 bronze powder mix can be consolidated to a virtually pore-free condition by hot pressing at 880°C. Although the as-consolidated material is inferior to cobalt, it displays a favourable combination of hardness, yield strength and ductility, and seems to have a great potential for moderate and general purpose applications.
Effects of high‐dose granulocyte colony‐stimulating factor on neutrophil functions

We evaluated the effects of high‐dose recombinant human granulocyte colony‐stimulating factor (rhG‐CSF) therapy on N‐formyl‐methionyl‐leucyl‐phenylalanine (FMLP)‐induced chemotaxis and superoxide (O −2) production in neutrophils from four patients with aplastic anaemia. The FMLP‐induced chemotaxis and O −2 production in the neutrophils of all four patients were normal before the rhG‐CSF treatment. After the administration of high‐dose rhG‐CSF, chemotaxis in agarose was decreased, adherence and O −2 production were enhanced in all the patients. An excessive increase of neutrophils with augmented adhesiveness and oxygen radical production may be harmful. Care should be taken in regard to neutrophil toxicity when high‐dose G‐CSF is used clinically.
Chlorpromazine in Women with Chronic Schizophrenia: The Effect on Cholesterol Levels and Cholesterol‐Behavior Relationships

&NA; In 2 carefully controlled studies with the same women with chronic schizophrenia, chlorpromazine was shown to raise serum cholesterol levels consistently and significantly. It was also a consistent finding that prior to chlorpromazine therapy cholesterol levels appeared to be related inversely to measures of withdrawal, seclusiveness, and gross psychopathology. After chlorpromazine therapy the cholesterol‐behavior relationships were no longer apparent.
Comparison of the genotyping results using DNA obtained from blood and saliva

Aim Traditionally, large scale genotyping projects have used DNA derived from whole-blood or lymphoblast cell lines. But over the past several years, a number of investigators have begun to use DNA prepared from saliva for genotyping studies, particularly for use in behavioral genetic studies. However, the comparability of DNA from these two sources has not been rigorously analyzed by unbiased sources. Objective In this communication, we compare the single nucleotide polymorphism genotyping results from DNA derived from whole-blood samples obtained from 474 participants from the Iowa Adoption Studies with that of saliva samples prepared from 555 members of the Strong African–American Families project. Results We found that DNA prepared from whole-blood performed significantly better than that prepared from saliva. Genotyping success was significantly associated with the concentration of human DNA in the saliva sample as determined by quantitative PCR, but not with the total amount of DNA as determined by UV spectroscopy. Conclusion We conclude that investigators contemplating the choice of source materials of DNA for genotyping studies will need to balance the ease and economy of saliva-based DNA collection methods with the higher yields and rates of genotyping calls associated with DNA prepared from whole-blood.
On-board control in the RoboCup small robots league

We present the most recent version of our RoboCube system, a special robot controller hand-tailored for players in the small robots league. The RoboCube is conceptualized to implement players with as many on-board features as possible in an extremely flexible way. For this purpose, the RoboCube provides significant computation power and memory as well as a multitude of I/O interfaces within the space constraints. As it facilitates the use of many sensors and effectors, including their on-board processing, the RoboCube allows us to explore a large number of different robots and team set-ups.
The Role of Large-Scale Motions in Catalysis by Dihydrofolate Reductase

Dihydrofolate reductase has long been used as a model system to study the coupling of protein motions to enzymatic hydride transfer. By studying environmental effects on hydride transfer in dihydrofolate reductase (DHFR) from the cold-adapted bacterium Moritella profunda (MpDHFR) and comparing the flexibility of this enzyme to that of DHFR from Escherichia coli (EcDHFR), we demonstrate that factors that affect large-scale (i.e., long-range, but not necessarily large amplitude) protein motions have no effect on the kinetic isotope effect on hydride transfer or its temperature dependence, although the rates of the catalyzed reaction are affected. Hydrogen/deuterium exchange studies by NMR-spectroscopy show that MpDHFR is a more flexible enzyme than EcDHFR. NMR experiments with EcDHFR in the presence of cosolvents suggest differences in the conformational ensemble of the enzyme. The fact that enzymes from different environmental niches and with different flexibilities display the same behavior of the kinetic isotope effect on hydride transfer strongly suggests that, while protein motions are important to generate the reaction ready conformation, an optimal conformation with the correct electrostatics and geometry for the reaction to occur, they do not influence the nature of the chemical step itself; large-scale motions do not couple directly to hydride transfer proper in DHFR.