Miracle-dz/UniFAR-FTUs huggingface dataset:
Review of titanium dioxide nanoparticle phototoxicity: Developing a phototoxicity ratio to correct the endpoint values of toxicity tests

Titanium dioxide nanoparticles are photoactive and produce reactive oxygen species under natural sunlight. Reactive oxygen species can be detrimental to many organisms, causing oxidative damage, cell injury, and death. Most studies investigating TiO2 nanoparticle toxicity did not consider photoactivation and performed tests either in dark conditions or under artificial lighting that did not simulate natural irradiation. The present study summarizes the literature and derives a phototoxicity ratio between the results of nano‐titanium dioxide (nano‐TiO2) experiments conducted in the absence of sunlight and those conducted under solar or simulated solar radiation (SSR) for aquatic species. Therefore, the phototoxicity ratio can be used to correct endpoints of the toxicity tests with nano‐TiO2 that were performed in absence of sunlight. Such corrections also may be important for regulators and risk assessors when reviewing previously published data. A significant difference was observed between the phototoxicity ratios of 2 distinct groups: aquatic species belonging to order Cladocera, and all other aquatic species. Order Cladocera appeared very sensitive and prone to nano‐TiO2 phototoxicity. On average nano‐TiO2 was 20 times more toxic to non‐Cladocera and 1867 times more toxic to Cladocera (median values 3.3 and 24.7, respectively) after illumination. Both median value and 75% quartile of the phototoxicity ratio are chosen as the most practical values for the correction of endpoints of nano‐TiO2 toxicity tests that were performed in dark conditions, or in the absence of sunlight. Environ Toxicol Chem 2015;34:1070–1077. © 2015 The Author. Published by SETAC.
Dual band notched small monopole antenna with a novel T-shaped slot for UWB applications

A new type of ultra-wideband (UWB) antenna with a dual-notched frequency band, compact size of 12×15mm2 and a coplanar waveguide (CPW) fed is proposed in this article. Two notched frequency bands are obtained by embedding two L-shaped slots in the radiation patch and a T-slot in the feed line and a V-shaped strip in the ground plane. Antenna has an impedance bandwidth ranging more than 140% from 2.75GHz to 18.46GHz in which voltage standing wave ratio is less than 2, expect two notch Frequency.
The differentiated form of nasopharyngeal carcinoma contains epstein‐barr virus DNA

Immunologic studies of Epstein‐Barr virus (EBV) have implicated EBV in undifferentiated and partially differentiated, non‐keratinizing nasopharyngeal carcinoma (NPC). Patients with the well‐differentiated, keratinizing form of NPC have EBV serologic patterns similar to those of control populations. In addition, viral DNA has not been detected in the differentiated tumors using viral cRNA probes to DNA immobilized on filters. In this study we have tested for EBV DNA using recombinant DNA probes to Southern blots of DNA from 33 NPC specimens. The 24 undifferentiated and 4 partially differentiated specimens generally contained a relatively high number of EBV genome equivalents, while the 5 well‐differentiated NPC all contained detectable EBV, but at low copy number. The viral DNA from one of the well‐differentiated specimens was cloned into a cosmid vector. Five recombinant clones representing the fused viral termini were obtained, indicating the presence of episomal, intracellular DNA in the tumor. These findings indicate that all histologic subsets of NPC contain EBV DNA.
Would 'The Making of the English Working Class' get made today?

It is fifty years since leftist publisher Victor Gollancz published The Making of the English Working Class by English historian Edward Palmer Thompson (1924–1993). During 2013, this event has been, and is being, commemorated globally in political and scholarly conferences and journals. My dilapidated copy is the Penguin revised edition (1968), purchased in 1970. Still in print, and with more than a million copies sold worldwide, Thompson’s hugely influential doorstop book is regarded as a pivotal exploration of social history, as much an historical classic as it is a literary classic. The book runs to some 900 pages and over a quartermillion words.
AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models

Constitutive activation of the extracellular signal-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase (MAPK) signaling pathway in human cancers is often associated with mutational activation of BRAF or RAS. MAPK/ERK kinase 1/2 kinases lie downstream of RAS and BRAF and are the only acknowledged activators of ERK1/2, making them attractive targets for therapeutic intervention. AZD6244 (ARRY-142886) is a potent, selective, and ATP-uncompetitive inhibitor of MAPK/ERK kinase 1/2. In vitro cell viability inhibition screening of a tumor cell line panel found that lines harboring BRAF or RAS mutations were more likely to be sensitive to AZD6244. The in vivo mechanisms by which AZD6244 inhibits tumor growth were investigated. Chronic dosing with 25 mg/kg AZD6244 bd resulted in suppression of growth of Colo-205, Calu-6, and SW-620 xenografts, whereas an acute dose resulted in significant inhibition of ERK1/2 phosphorylation. Increased cleaved caspase-3, a marker of apoptosis, was detected in Colo-205 and Calu-6 but not in SW-620 tumors where a significant decrease in cell proliferation was detected. Chronic dosing of AZD6244 induced a morphologic change in SW-620 tumors to a more differentiated phenotype. The potential of AZD6244 in combination with cytotoxic drugs was evaluated in mice bearing SW-620 xenografts. Treatment with tolerated doses of AZD6244 and either irinotecan or docetaxel resulted in significantly enhanced antitumor efficacy relative to that of either agent alone. These results indicate that AZD6244 has potential to inhibit proliferation and induce apoptosis and differentiation, but the response varies between different xenografts. Moreover, enhanced antitumor efficacy can be obtained by combining AZD6244 with the cytotoxic drugs irinotecan or docetaxel. [Mol Cancer Ther 2007;6(8):2209–19]
Implementation of Different Wavelets in an Auto-Tuning Wavenet PID Controller and Its Application to a DC Motor

This paper shows the results obtained experimentally by controlling the speed of a DC motor using different wavelets (Morlet, RASP1, RASP2, RASP3, POLYWOG1, POLYWOG3, POLYWOG4 and Shannon) in an auto-tuning wavenet PID controller. Such controller tunes online the proportional, integral and derivative gains of a classical discrete PID controller, through the identification of the plant using a radial basis neural network with different daughters wavelet activation functions, in cascade with an infinite impulse response filter.
Periodontal bacterial invasion and infection: contribution to atherosclerotic pathology.

OBJECTIVE The objective of this review was to perform a systematic evaluation of the literature reporting current scientific evidence for periodontal bacteria as contributors to atherosclerosis. METHODS Literature from epidemiological, clinical and experimental studies concerning periodontal bacteria and atherosclerosis were reviewed. Gathered data were categorized into seven "proofs" of evidence that periodontal bacteria: 1) disseminate from the oral cavity and reach systemic vascular tissues; 2) can be found in the affected tissues; 3) live within the affected site; 4) invade affected cell types in vitro; 5) induce atherosclerosis in animal models of disease; 6) non-invasive mutants of periodontal bacteria cause significantly reduced pathology in vitro and in vivo; and 7) periodontal isolates from human atheromas can cause disease in animal models of infection. RESULTS Substantial evidence for proofs 1 to 6 was found. However, proof 7 has not yet been fulfilled. CONCLUSIONS Despite the lack of evidence that periodontal bacteria obtained from human atheromas can cause atherosclerosis in animal models of infection, attainment of proofs 1 to 6 provides support that periodontal pathogens can contribute to atherosclerosis.
Atomic wedgie: efficient query filtering for streaming time series

In many applications, it is desirable to monitor a streaming time series for predefined patterns. In domains as diverse as the monitoring of space telemetry, patient intensive care data, and insect populations, where data streams at a high rate and the number of predefined patterns is large, it may be impossible for the comparison algorithm to keep up. We propose a novel technique that exploits the commonality among the predefined patterns to allow monitoring at higher bandwidths, while maintaining a guarantee of no false dismissals. Our approach is based on the widely used envelope-based lower bounding technique. Extensive experiments demonstrate that our approach achieves tremendous improvements in performance in the offline case, and significant improvements in the fastest possible arrival rate of the data stream that can be processed with guaranteed no false dismissal.
Double iterative waterfilling for sum rate maximization in multicarrier NOMA systems

This paper investigates the subcarrier and power allocation for the downlink of a multicarrier non-orthogonal multiple access (MC-NOMA) system. A three-step algorithm is proposed to deal with the sum rate maximization problem. In Step 1, we assume that each user can use all the subcarriers simultaneously and apply the synchronous iterative waterfilling algorithm (SIWA) to obtain a power vector for each user. In Step 2, subcarriers are assigned to users by a heuristic greedy method based on the achieved power allocation result of Step 1. In Step 3, SIWA is used once again to further improve the system performance with the obtained subcarrier assignment result of Step 2. The convergence of SIWA in Step 3 is proved when the number of multiplexed users is no more than two. Since SIWA is applied twice, we call our three-step method Double Iterative Waterfilling Algorithm (DIWA). Numerical results show that the proposed DIWA achieves comparable performance to an existing near-optimal solution but with much lower time complexity.
A Metal-Accumulator Mutant of Arabidopsis thaliana

A mutation designated man1 (for manganese accumulator) was found to cause Arabidopsis thaliana seedlings to accumulate a range of metals. The man1 mutation segregated as a single recessive locus located on chromosome 3. When grown on soil, mutant seedlings accumulated Mn (7.5 times greater than wild type), Cu (4.6 times greater than wild type), Zn (2.8 times greater than wild type), and Mg (1.8 times greater than wild type) in leaves. In addition to these metals, the man1 mutant accumulated 2.7-fold more S in leaves, primarily in the oxidized form, than wild-type seedlings. Analysis of seedlings grown by hydroponic culture showed a similar accumulation of metals in leaves of man1 mutants. Roots of man1 mutants also accumulated metals, but unlike leaves they accumulated 10-fold more total Fe (symplasmic and apoplasmic combined) than wild-type roots. Roots of man1 mutants possessed greater (from 1.8- to 20-fold) ferric-chelate reductase activity than wild-type seedlings, and this activity was not responsive to changes of Mn nutrition in either genotype. Taken together, these results suggest that the man1 mutation disrupts the regulation of metal-ion uptake or homeostasis in Arabidopsis.
Exploiting primary user social features for reliability-driven routing in multi-hop cognitive radio networks

In this paper, we study the routing problem in multi-hop cognitive radio networks (CRNs). We observe that Primary Users (PUs) in CRNs exhibit unevenly geographic distribution due to their social behaviors. In the area with densely-distributed PUs, the low spectrum availability will severely decrease the Secondary Users (SUs) communication reliability. We are motivated to exploit Primary User (PU) social features to set up a multi-hop routing path providing reliable end-to-end communications. There are two main challenges: 1) how to quantitatively represent and characterize PU social features in CRNs; 2) given the knowledge of the PU social features, how to design an efficient route to improve the packet-forwarding reliability. We first propose the concept of PU community in CRNs. Maximum likelihood estimation method is then employed to predict the number of potential PUs. The estimated results effectively reflect the spectrum utilization, and hence, provide important information for PU community formulation. After that, considering the existence of PU community, we propose a hybrid routing scheme to alleviate the impact of PU community on packet-forwarding reliability. Simulation results demonstrate that the proposed scheme significantly improves the reliability of end-to-end communications.
Worldviews on Evidence-based Nursing

The leading nursing society that has brought you the Journal of Nursing Scholarship is now pleased to introduce its new journal Worldviews on Evidence-Based Nursing. A quarterly, peer-reviewed, journal and information resource from The Honor Society of Nursing, Sigma Theta Tau International and Blackwell Publishing, the journal uniquely bridges knowledge and application taking a global approach in its presentation of research, policy and practice, education and management.
Ever-present factors in healthy children that can deform their spines. Opposition to Dickson's paradigm on lordosis.

: Revision of older knowledge on spinal deformities shows causing factors in all day life and the source of rotational forces in men in respiration. The role of lordosis as a causative factor can change towards a correcting force, supported by different studies. The thoracolumbar spine is the originating area of many deforming processes.
New Stx2e Monoclonal Antibodies for Immunological Detection and Distinction of Stx2 Subtypes

Background Stx2e is a primary virulence factor in STEC strains that cause edema disease in neonatal piglets. Though Stx2a and Stx2e are similar, many antibody-based Stx detection kits are designed to detect Stx2a and do not recognize the Stx2e subtype. Methods and Findings Four monoclonal antibodies against Stx2e were developed and characterized. Two of these mAbs recognize the B subunit of Stx2e, Stx2f, and to a lesser extent, Stx2b, Stx2c, and Stx2d. The other two mAbs recognize the A subunit of Stx2e, and cross-react with all Stx2 subtypes except Stx2f. The most sensitive sandwich ELISA using these mAbs has a limit of detection for Stx2e of 11.8 pg/mL. The ability of the neutralizing antibody Stx2e-2 to block Stx2e-receptor binding in Vero cells was visualized using immunofluorescence. Combinations of these and previously developed mAbs permit ELISA-based differentiation between closely related Stx2a, Stx2c, and Stx2d (using mAbs Stx2-5/2-1, Stx2-5/2e-2, and Stx2e-3/2e-2, respectively). Conclusions The sensitive immunoassays developed in this study should augment our capacity to detect Stx2e in porcine environments and biological samples. Moreover, immunoassays that can distinguish between the closely related Stx2a, Stx2c, and Stx2d subtypes can be useful in quickly analyzing Stx subtypes in samples containing more than one strain of STEC.
EXPERIMENTAL CONGENITAL TOXOPLASMOSIS

Pregnant mice infected with Toxoplasma by the vaginal route have been found to transmit toxoplasmosis to the placentas and fetuses in utero. The microorganism entered the blood stream of the mother from primary foci of infection in the vaginal wall and produced disseminated lesions in the labyrinth of the allantoic placenta at the same time as other peripheral maternal tissues were involved. Placental lesions were observed in mice infected with Toxoplasma by vagina between the 3rd and the 9th day of pregnancy. They consisted of microscopic foci of degeneration, without inflammation, in the syncytial trophoblast, and parasites undergoing multiplication were readily identified in them. Here Toxoplasma gained access to the fetal circulation. Following the vaginal instillation of Toxoplasma on the 8th day of pregnancy, subinoculation of test animals revealed the parasites in the maternal peripheral and placental blood on the 13th day and later, while the first histopathologic changes in the placenta were found on the 17th day. Toxoplasma could be demonstrated in suspensions of fetal tissues on and after the 17th day by the injection of normal test animals. However, no lesions of toxoplasmosis, or Toxoplasma, were found in histologic sections of fetuses 11 to 21 days old removed at autopsy from vaginally infected mothers. It is concluded that before birth the parasites were confined to the fetal blood. The experiments provide the first direct histological demonstration of placental toxoplasmosis. The possible bearing of the experimental disease on human placental and fetal toxoplasmosis is briefly considered. It is probable that a maternal parasitemia during the latter part of pregnancy, whatever the portal of entry may be, is an essential factor in the pathogenesis of human congenital toxoplasmosis and that this occurs shortly after exposure to Toxoplasma rather than in a later chronic stage of the infection. The suggestion is offered that some instances of spontaneous abortion or fetal death in man, as in the mouse, may be due to inapparent toxoplasmosis.
Shade Face: Multiple image-based 3D face recognition

Three-dimensional face recognition is illumination invariant, however the acquisition process itself is not. In active 3D recognition, multiple images are captured while the face is actively illuminated with different patterns. We propose a 3D face recognition paradigm that bypasses reconstruction and exploits the plethora of information available in multiple images of a person acquired while varying the illumination. Illumination is varied by scanning a horizontal and then a vertical white stripe on the computer screen in front of the subject. Subtracting ambient light leaves images illuminated by the screen from different angles. The contourlet coefficients of the images are calculated at different scales and orientations and then projected to PCA subspace to remove redundancy. The subspace contourlet coefficients of multiple images are stacked to form a global face representation. Sliding windows are used during matching to remove the disparity between the face locations with respect to the screen. The proposed algorithm was tested under varying ambient conditions and compared to a known 3D face recognition technique. Verification results on data from the same subjects show the strength of our algorithm.
Reduced susceptibility to biocides in Acinetobacter baumannii: association with resistance to antimicrobials, epidemiological behaviour, biological cost and effect on the expression of genes encoding porins and efflux pumps.

OBJECTIVES The objective of this study was to analyse whether there is an association between reduced susceptibility to biocides in Acinetobacter baumannii and (i) antimicrobial resistance (co-resistance), (ii) prevalent (epidemic) clones, (iii) changes in the fitness or (iv) expression of genes related to efflux pumps and porins. METHODS Susceptibility to biocides and antimicrobials was determined in 49 clonally unrelated isolates of A. baumannii. Biological cost, in terms of mean generation time, was determined by spectrophotometry. Quantitative real-time RT-PCR was used to determine the relative expression of genes encoding several efflux pumps and porins. RESULTS Reduced susceptibility to chlorhexidine digluconate, benzalkonium chloride and Irgasan(®) was associated with resistance to aminoglycosides, tetracycline and ciprofloxacin (P < 0.05). The MICs of carbapenems, aminoglycosides, doxycycline and ciprofloxacin for isolate Ab70 (epidemic clone) exposed to these biocides increased by ≥2 dilutions. Reduced susceptibility to Orsan(®) was more frequent among prevalent clones than non-prevalent clones (P < 0.05). Mean generation times for Ab70 before and after exposure to benzalkonium chloride were 57.8 and 78.1 min, respectively (P = 0.02). Relative expression of abeS and adeB was increased in Ab46 and Ab70 after exposure to chlorhexidine digluconate, but was decreased for ompA and carO after exposure to Irgasan(®). CONCLUSIONS Reduced susceptibility to biocides is associated with co-resistance to carbapenems, aminoglycosides, tetracycline and ciprofloxacin. Reduced susceptibility to Orsan(®) may be a marker of prevalent clones. Acquisition of reduced susceptibility to benzalkonium chloride has a biological cost. Exposure to biocides affects the relative expression of genes related to some efflux pump genes (increased expression) or porins (reduced expression).
Vulnerability of Currency Pegs : Evidence From Brazil Bernardo Guimaraes

This paper analyses predictions of a simple model of currency crises in which the peg will be abandoned when the currency overvaluation hits a certain threshold, unknown to the agents. Due to learning about the threshold, some features usually observed in the data and identified with models with multiple equilibria arise in the model. But the model yields distinctive predictions about the behaviour of the probability and the expected magnitude of a currency devaluation. The paper identifies the probability and expected magnitude of a devaluation of Brazilian Real in the period leading up to the end of the Brazilian pegged exchange rate regime, using data on exchange rate options. The empirical results are consistent with model predictions.
SCant-design: Closed loop supply chain design using ant colony optimization

This paper proposes a new optimization methodology for supply chain design, using ant colony optimization. The objective of this methodology is to choose the facilities that will take part in a multi-product closed-loop supply chain, such as factories, warehouses and disassembly centers, in order to minimize the costs related to these facilities and those related to transportation costs, both in the forward and reverse chains. Considering that total production quantities for factories, expected cross-docking stocks for warehouses, and disassembly centers are determined by this methodology, it can be considered that it undertakes both strategic and tactical Supply Chain Management (SCM) problems at once. The developed algorithm, SCant-Design, is sufficiently general to solve any SCM configuration, with linear and nonlinear cost functions and constraints. The algorithm results were compared to a MILP approach for a particular case study and the obtained value for the cost function is very similar, although using less facilities.
Anger and Cancer: AN ANALYSIS OF THE LINKAGES

The purposes of this article are to review literature on anger’s link to cancer, to analyze the state of the science in this area, and to propose some directions for future research. Extremely low anger scores have been noted in numerous studies of patients with cancer. Such low scores suggest suppression, repression, or restraint of anger. There is evidence to show that suppressed anger can be a precursor to the development of cancer, and also a factor in its progression after diagnosis. Some studies indicate that it may be beneficial for patients to mobilize anger to battle their cancer. However, there is a paucity of research on the outcomes of various anger interventions. Longitudinal studies that repeatedly measure anger and other moods over the disease trajectory are needed.