Miracle-dz/UniFAR-FTUs huggingface dataset:
Contributions of work—life and resilience initiatives to the individual/organization relationship

Despite much research, it remains unclear whether and how organizational work—life and resilience initiatives (WLRI) enhance employee commitment. To open this black box, this theory-building research analyses 73 in-depth interviews in a multinational pharmaceutical company. WLRI foster desirable outcomes for almost two-thirds of the sample (loyalty, pride, calculated appreciation and use as management tools), yet may have negative outcomes (disappointment, obligation to stay) or no outcome (indifference). To understand the processes implied, this research analyses employees’ awareness, need, access and judgment of the initiatives. A decision tree was built. Key success conditions lie in three layers of context: personal, work environment and national. This article argues for a new theoretical foundation of work—life research, combining classic individual-centred perspectives with relational theories, which remain under-investigated in work—life research.
The myth of job readiness? Written communication, employability, and the ‘skills gap’ in higher education

Recent developments in higher education have seen a strong emphasis placed on making graduates ‘job ready’ for their work in the professions. A driver of this agenda has been the many mass-scale surveys conducted with business and industry about the abilities and general employability of graduates. This Australian-based study is focused on perceptions and attitudes around one such ability – professional writing skills. ‘Discourse-based interviews' were conducted with managers and supervisors from a range of professional areas. Their responses were most interesting, and served, among other things, to challenge some of the emerging ideas about ‘job readiness’ in current debates about the directions of higher education.
Density-Based Multiscale Data Condensation

A problem gaining interest in pattern recognition applied to data mining is that of selecting a small representative subset from a very large data set. In this article, a nonparametric data reduction scheme is suggested. It attempts to represent the density underlying the data. The algorithm selects representative points in a multiscale fashion which is novel from existing density-based approaches. The accuracy of representation by the condensed set is measured in terms of the error in density estimates of the original and reduced sets. Experimental studies on several real life data sets show that the multiscale approach is superior to several related condensation methods both in terms of condensation ratio and estimation error. The condensed set obtained was also experimentally shown to be effective for some important data mining tasks like classification, clustering, and rule generation on large data sets. Moreover, it is empirically found that the algorithm is efficient in terms of sample complexity.
Virtual camera view composing method using monocular camera for mobile robot teleoperation

It is important for an operator to easily understand surroundings of a mobile robot in teleoperation. We propose a new virtual camera view composing method in this paper. The virtual camera view consists of a real time image captured with a monocular camera mounted on the mobile robot and a virtual image generated from 3D measurement results of image features and stored images while the mobile robot is moving. Since the field of view of the virtual camera view is wider than that of the real camera view, the operator can see the left and right sides of the mobile robot, and this virtual image makes the teleoperation control easier.
Regulation of Insulin Receptor mRNA Splicing in Rat Tissues: Effect of Fasting, Aging, and Diabetes

Recent findings suggested that alterations in insulin receptor isoform expression might be involved in the molecular mechanism of insulin resistance. Using reverse transcription reaction followed by competitive polymerase chain reaction, we measured the level of the receptor mRNA variants in rat insulin-sensitive tissues, under conditions of decreased insulin effectiveness (fasting, aging, and diabetes). The liver expressed the mRNA variant with exon 11 predominantly, and the hind limb skeletal muscles expressed the mRNA without exon 11. The heart and epididymal adipose tissue expressed both variants. Fasting and streptozocin-induced diabetes increased the level of receptor mRNAs in the liver but did not modify the repartition between the two variants. The modification of the expression ratio, in favor of the form with exon 11, found by some authors in the skeletal muscle of insulin-resistant patients was not observed in rat muscles that expressed >99% of the form without exon 11 under all the conditions tested. In adipose tissue, the proportion of both mRNA variants was never altered (45% of exon 11-positive [Ex11+]), while the total receptor mRNA concentration changed markedly during fasting or aging. The only modification observed in the isoform distribution was a significant decrease in Ex11+ mRNA concentration in the liver, muscle, and heart of old rats. We conclude that alternative splicing of insulin receptor mRNA is not involved in the impairment of insulin action during fasting or diabetes. Its potential role in the insulin resistance of old animals remains to be defined.
The Audience is listening : Nutzung und Akzeptanz von Weblogs im Bundestagswahlkampf 2005

Nach ersten Gehversuchen bei der Landtagswahl in Nordrhein-Westfalen haben sich Weblogs im Vorfeld der Bundestagswahl 2005 zu einem neuen Wahlkampfinstrument der Parteien und zu einer neuen politischen Informationsund Diskussionsplattform für die Wahlberechtigten entwickelt. Die Veränderung ihrer Akzeptanz und Nutzung im Vorfeld der Wahl wurde mit Hilfe einer zweiwelligen Onlineumfrage unter politisch interessierten Internetnutzern untersucht. Politische Weblogs sind demnach nur durch eine kleine Gruppe als neue Möglichkeit der Information und des politischen Meinungsaustausches im Wahlkampf herangezogen worden. Die Rezipienten der Inhalte unterscheiden sich dabei deutlich von den Weblog-Autoren, die generell wesentlich stärker vom Nutzen, vom Einfluss und vor allem von der Glaubwürdigkeit politischer Weblogs überzeugt sind. Allerdings zeigt sich im Verlauf des Wahlkampfes eine Angleichung der Einstellungen beider Nutzergruppen.
CITIZENSHIP EDUCATION AND YOUTH PARTICIPATION IN DEMOCRACY

ABSTRACT: Citizenship education in established democracies is challenged by declining youth participation in democracy. Youth disenchantment and disengagement in democracy is primarily evident in formal political behaviour, especially through voting, declining membership of political parties, assisting at elections, contacting politicians, and the like. If citizenship education is to play a major role in addressing these concerns it will need to review the impact it is making on young people in schools. This paper reviews a major national project on youth participation in democracy in Australia set in the context of a national citizenship education programme. The Youth Electoral Study found that citizenship education in Australian schools has at best been marginally successful and substantially more is required to raise levels of democratic engagement. The paper explores many opportunities available to education systems and schools to address these issues through reconceptualising aspects of the formal and the informal curriculum.
Caching Doesn't Improve Mobile Web Performance (Much)

A recent NSDI paper [1] reported that increasing the cache hit ratio for an HTTP proxy from 22% to 32% improved median page load time (PLT) for mobile clients by less than 2%. We argue that there are two main causes for this weak improvement: objects on the critical path are often not cached, and the limited computational power of mobile devices causes computational delays to comprise a large portion of the critical path. Both of these factors were, in fact, outlined by a previous analysis of desktop web performance [2]. However, we (as the authors of the HTTP proxy [1]) did not properly understand the analysis and could have saved ourselves substantial engineering costs if we had. We therefore argue for the need to highlight this prior analysis, and extend the analysis to include mobile devices with slow CPUs, precise cache hit ratios, and a controlled reproduction of the HTTP proxy caching results [1]. In the extreme case of a perfect cache hit ratio, desktop page load times are improved notably by 34% compared to no caching, but mobile page load times only improve by 13% in the median case. We extract a back-of-envelope performance model from these results to help understand their underlying causes.
Discovery of Pectin-degrading Enzymes and Directed Evolution of a Novel Pectate Lyase for Processing Cotton Fabric*

There is a growing need in the textile industry for more economical and environmentally responsible approaches to improve the scouring process as part of the pretreatment of cotton fabric. Enzymatic methods using pectin-degrading enzymes are potentially valuable candidates in this effort because they could reduce the amount of toxic alkaline chemicals currently used. Using high throughput screening of complex environmental DNA libraries more than 40 novel microbial pectate lyases were discovered, and their enzymatic properties were characterized. Several candidate enzymes were found that possessed pH optima and specific activities on pectic material in cotton fibers compatible with their use in the scouring process. However, none exhibited the desired temperature characteristics. Therefore, a candidate enzyme was selected for evolution. Using Gene Site Saturation Mutagenesis™ technology, 36 single site mutants exhibiting improved thermotolerance were produced. A combinatorial library derived from the 12 best performing single site mutants was then generated by using Gene Reassembly™ technology. Nineteen variants with further improved thermotolerance were produced. These variants were tested for both improved thermotolerance and performance in the bioscouring application. The best performing variant (CO14) contained eight mutations and had a melting temperature 16 °C higher than the wild type enzyme while retaining the same specific activity at 50 °C. Optimal temperature of the evolved enzyme was 70 °C, which is 20 °C higher than the wild type. Scouring results obtained with the evolved enzyme were significantly better than the results obtained with chemical scouring, making it possible to replace the conventional and environmentally harmful chemical scouring process.
How secure is your smartphone: An analysis of smartphone security mechanisms

Smartphones are becoming more and more popular due to the increase in their processing power, mobility aspect and personal nature. Android is one of the most popular and fully customizable open source mobile platforms that come with a complete software stack. One of the main reasons behind the rapid growth in adoption of smartphones is their capability to facilitate users with third-party applications. Android offers hundreds of thousands of applications via application markets and users can readily install these applications. However, this rapid growth in smartphone usage and the ability to install third-party applications has given rise to several security concerns. In this paper, we present the current state of smartphone security mechanisms and their limitations in order to identify certain security requirements for proposing enhancements for the smartphone security model. We analyze the improvements proposed for the basic Android security model and discuss their advantages and limitations in detail. We also present certain security requirements that need to be fulfilled in order to design and implement security enhancements for Android that can be widely adopted by the broader community.
Development of heart valve lesions during methysergide therapy.

and a high incidence of uncertain scan findings, to be used as the only method of search for secondary deposits. The greater accuracy of "9mTc polyphosphate makes it more suitable as the principle means of search though in one patient of the 61 investigated with this isotope we were unable to identify metastases which were clinically and radiologically evident. Care also needs to be used in the interpretation of positive results since an isotopic "hot spot" is a non-specific indicator of abnormal metabolic bone activity and can therefore be produced by any metabolically active lesion, such as are seen, for example, in Paget's disease. We do not envisage that polyphosphate scintigraphy will completely replace x-ray examination in the identification of bone metastases, but we do feel that it should be used as the principle "search weapon" both in the initial assessment of the patient with prostatic cancer and in the continuing management of the disease.
Reliability of Percutaneous Nephrolithotomy in Pediatric Patients: Comparison of Complications With Those in Adults

Purpose To assess the reliability of percutaneous nephrolithotomy (PNL) in pediatric patients by comparing complications between pediatric patients and adults by use of the modified Clavien grading system. Materials and Methods The data of 74 pediatric (0 to 16 years) and 535 adult (17 years and older) patients who underwent PNL owing to kidney stone disease between January 2005 and December 2011 were analyzed retrospectively. The complications in the pediatric and adult patients were classified in five grades according to the modified Clavien system. Results The most frequent cause of grade I complications was fever requiring antipyretics, which was seen in 4 pediatric patients (5.4%) and 30 adult patients (5.6%). Grade II complications (blood transfusions, <12 hours urinary leakage) were observed in 11 pediatric patients (14.8%) and 80 adult patients (14.9%). Grade III complications were also seen in 6 pediatric patients (8.1%) (grade IIIb; D-J catheter implantation under general anesthesia) and 78 adult patients (14.5%) (grade IIIa; D-J catheter implantation and angio-embolization under local anesthesia). There was no statistically significant difference between the two groups in terms of grade I, II, or III complications (p>0.05). Colonic injury occured in one patient (1.3%) in the pediatric group (grade IVa). In the adult group, one patient (0.2%) died as the result of myocardial infarction (grade V). Conclusions Thanks to technological developments and minimalization of the equipment used, when indicated, pediatric patients can be safely treated with PNL with low complication rates similar to those in adult patients.
Inclusive Education in Botswana: The Perceptions of School Teachers

The purpose of this study was to identify the attitudes and concerns of teachers toward the inclusion of students with disabilities in the general classroom. The findings indicate that teachers in Botswana have somewhat negative attitudes with some concern about inclusive education. Significant correlation was observed between attitudes and concerns (r = .323). The results also reveal that many regular teachers feel unprepared and fearful to work with learners with disabilities in regular classes and so display frustration, anger, and negative attitudes toward inclusive education because they believe that it could lead to lower academic standards.
Conversion of omnipotent translation termination factor eRF1 into ciliate‐like UGA‐only unipotent eRF1

In eukaryotic ribosomes, termination of translation is triggered by class 1 polypeptide release factor, eRF1. In organisms with a universal code, eRF1 responds to three stop codons, whereas, in ciliates with variant codes, only one or two codon(s) remain(s) as stop signals. By mutagenesis of the Y–C–F minidomain of the N domain, we converted an omnipotent human eRF1 recognizing all three stop codons into a unipotent ‘ciliate‐like’ UGA‐only eRF1. The conserved Cys127 located in the Y–C–F minidomain plays a critical role in stop codon recognition. The UGA‐only response has also been achieved by concomitant substitutions of four other amino acids located at the Y–C–F and NIKS minidomains of eRF1. We suggest that for eRF1 the stop codon decoding is of a non‐linear (non‐protein‐anticodon) type and explores a combination of positive and negative determinants. We assume that stop codon recognition is profoundly different by eukaryotic and prokaryotic class 1 RFs.
Leverage Aversion and Risk Parity

The authors show that leverage aversion changes the predictions of modern portfolio theory: Safer assets must offer higher risk-adjusted returns than riskier assets. Consuming the high risk-adjusted returns of safer assets requires leverage, creating an opportunity for investors with the ability to apply leverage. Risk parity portfolios exploit this opportunity by equalizing the risk allocation across asset classes, thus overweighting safer assets relative to their weight in the market portfolio. In our article, we show that leverage aversion changes the predictions of modern portfolio theory: It implies that safer assets must offer higher risk-adjusted returns than riskier assets because leverage-averse investors tilt their portfolio toward riskier assets to achieve high unleveraged returns, thus pushing up the prices of risky assets and reducing the expected return on those assets. Therefore, safer assets are in relatively low demand and offer high risk-adjusted returns. Consuming the high risk-adjusted returns offered by safer assets requires leverage, which creates an opportunity for investors with the ability and willingness to apply leverage. A risk parity (RP) portfolio exploits the high risk-adjusted returns of safer assets in a simple way—namely, by equalizing the risk allocation across asset classes and thus overweighting safer assets and underweighting riskier assets relative to their weights in the market portfolio. Although an unleveraged RP portfolio has a lower risk than the market portfolio (and the 60/40 portfolio) owing to the higher allocation to safer assets, the RP portfolio can be leveraged to achieve the same risk as the market portfolio and a higher expected return. Consistent with our theory of leverage aversion, we found empirically that risk parity has outperformed the market over the last century by a statistically and economically significant amount. Indeed, in the United States, an RP portfolio with the same risk as the market portfolio outperformed the market portfolio by about 4 percent a year over 1926–2010. Furthermore, the RP portfolio delivered higher risk-adjusted returns than the 60/40 portfolio in each of the 11 countries covered by the J.P. Morgan Global Government Bond Index over 1986–2010. We performed extensive robustness tests and analyzed the related evidence across and within countries and asset classes. Editor’s Note: The authors are affiliated with AQR Capital Management, LLC, which offers risk parity funds.
Defining the Nature of Thermal Intermediate in 3 State Folding Proteins: Apoflavodoxin, a Study Case

The early stages of the thermal unfolding of apoflavodoxin have been determined by using atomistic multi microsecond-scale molecular dynamics (MD) simulations complemented with a variety of experimental techniques. Results strongly suggest that the intermediate is reached very early in the thermal unfolding process and that it has the properties of an “activated” form of the native state, where thermal fluctuations in the loops break loop-loop contacts. The unrestrained loops gain then kinetic energy corrupting short secondary structure elements without corrupting the core of the protein. The MD-derived ensembles agree with experimental observables and draw a picture of the intermediate state inconsistent with a well-defined structure and characteristic of a typical partially disordered protein. Our results allow us to speculate that proteins with a well packed core connected by long loops might behave as partially disordered proteins under native conditions, or alternatively behave as three state folders. Small details in the sequence, easily tunable by evolution, can yield to one or the other type of proteins.
Primary and preschool immunisation in Grampian: progress and the 1990 contract.

OBJECTIVE--To examine changes in immunisation performance in Grampian region after the introduction of the 1990 contract for general practitioners. DESIGN--Retrospective descriptive study using data held on the Grampian immunisation record system's computer. SETTING--All 95 general practices in Grampian region (313 general practitioners). PATIENTS--All children in the primary immunisation and preschool booster age groups. This formed two groups of children for each of the four calendar quarters of 1990 and first three quarters of 1991 analysed as (a) those aged 2 years on the first day of the relevant quarter and (b) those aged 5 years on the first day of the relevant quarter, with an average population of 6600 and 6400 respectively. MAIN OUTCOME MEASURE--Percentage immunised by practice. RESULTS--For primary immunisation the number of practices achieving immunisation rates of at least 95% increased from 29 (31%) to 76 (81%), and practices achieving 90% rates rose from 69 (73%) to 87 (93%). For preschool boosters, the number of practices achieving at least 95% immunisation rates increased from 22 (23%) to 61 (64%). By the end of September 1991, 76 (80%) practices were achieving at least 90% levels compared with 36 (39%) at the beginning of 1990. Since the beginning of 1989 the proportion of immunisations not given by general practitioners declined from 14% to 2%. CONCLUSIONS--Primary and preschool immunisation rates for preschool children in Grampian showed a sustained improvement during 1990 and consolidation in 1991. Although overall trends were unchanged, 18 months after the introduction of the 1990 contract only one practice failed to meet lower target levels of 70% for both primary and preschool immunisation. By September 1991 more than three out of four practices had reached levels of at least 95% for primary immunisation.
Survivorship care plans in research and practice

The Institute of Medicine (IOM) recommends the use of survivorship care plans (SCPs) for all cancer survivors. Developing useful SCPs requires understanding what survivors and their providers need and how SCPs can be implemented in practice. Published studies investigating the perspectives of stakeholders (survivors, primary care providers, and oncology providers) were reviewed regarding the content and use of SCPs. All National Cancer Institute (NCI)‐designated cancer centers were surveyed concerning the extent to which SCPs for survivors of breast and colorectal cancers are in use, their concordance with the IOM's recommendation, and details about SCP delivery. Survivors and primary care providers typically lack the information the IOM suggested should be included in SCPs. Oncology providers view SCPs favorably but express concerns about the feasibility of their implementation. Fewer than one‐half (43%) of NCI‐designated cancer centers deliver SCPs to their breast or colorectal cancer survivors. Of those that do, none deliver SCPs that include all components recommended by the IOM. Survivors' and providers' opinions about the use of SCPs are favorable, but there are barriers to implementation. SCPs are not widely used in NCI‐designated cancer centers. Variation in practice is substantial, and many components recommended by the IOM framework are rarely included. CA Cancer J Clin 2012; © 2012 American Cancer Society.