Miracle-dz/UniFAR-FTUs huggingface dataset:
Functional Cardiac Magnetic Resonance Imaging in the Assessment of Myocardial Viability and Perfusion Health Technology Scientific Literature Review

Authors' conclusions There is some evidence that the accuracy of functional cardiac MRI compares favourably with alternate imaging techniques for the assessment of myocardial viability and perfusion. There is insufficient evidence whether functional cardiac MRI can better select which patients [who have CAD and severe LV dysfunction (LVEF less than 35 per cent)]may benefit from revascularization compared with an alternate noninvasive imaging technology. There is insufficient evidence whether functional cardiac MRI can better select which patients should proceed to invasive coronary angiography for the definitive diagnosis of CAD, compared with an alternate noninvasive imaging technology. There is a need for a large prospective (potentially multicentre) study with adequate follow-up time for patients with CAD and LV dysfunction (LVEF less than 35 per cent) comparing MRI and PET. Since longer followup time may be associated with restenosis or graft occlusion, it has been suggested to have serial measurements after revascularization.
Dynamic Stability of a Microgrid With an Active Load

Rectifiers and voltage regulators acting as constant power loads form an important part of a microgrid’s total load. In simplified form, they present a negative incremental resistance and beyond that, they have control loop dynamics in a similar frequency range to the inverters that may supply a microgrid. Either of these features may lead to a degradation of small-signal damping. It is known that droop control constants need to be chosen with regard to damping, even with simple impedance loads. Actively controlled rectifiers have been modeled in nonlinear state-space form, linearized around an operating point, and joined to network and inverter models. Participation analysis of the eigenvalues of the combined system identified that the low-frequency modes are associated with the voltage controller of the active rectifier and the droop controllers of the inverters. The analysis also reveals that when the active load dc voltage controller is designed with large gains, the voltage controller of the inverter becomes unstable. This dependence has been verified by observing the response of an experimental microgrid to step changes in power demand. Achieving a well-damped response with a conservative stability margin does not compromise normal active rectifier design, but notice should be taken of the inverter–rectifier interaction identified.
Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum

To achieve drug resistance Leishmania parasite alters gene copy number by using its repeated sequences widely distributed through the genome. Even though homologous recombination (HR) is ascribed to maintain genome stability, this eukaryote exploits this potent mechanism driven by the Rad51 recombinase to form beneficial extrachromosomal circular amplicons. Here, we provide insights on the formation of these circular amplicons by analyzing the functions of the Rad51 paralogs. We purified three Leishmania infantum Rad51 paralogs homologs (LiRad51-3, LiRad51-4 and LiRad51-6) all of which directly interact with LiRad51. LiRad51-3, LiRad51-4 and LiRad51-6 show differences in DNA binding and annealing capacities. Moreover, it is also noteworthy that LiRad51-3 and LiRad51-4 are able to stimulate Rad51-mediated D-loop formation. In addition, we succeed to inactivate the LiRad51-4 gene and report a decrease of circular amplicons in this mutant. The LiRad51-3 gene was found to be essential for cell viability. Thus, we propose that the LiRad51 paralogs play crucial functions in extrachromosomal circular DNA amplification to circumvent drug actions and preserve survival.
A novel co-operative mechanism linking TGFβ and Lyn kinase activation to imatinib resistance in chronic myeloid leukaemia cells

The advent of a mechanism specific inhibitor imatinib, targeting Bcr-Abl kinase, has paved the way for new treatment strategies in chronic myeloid leukaemia (CML). However, resistance to imatinib is common in patients and has recently been linked to both transforming growth factor-β (TGFβ) and elevated Lyn kinase activity, although molecular mechanisms remain largely unknown. Here, using leukaemic MYL cell lines derived from CML patients, we show that TGFβ plays a key role in imatinib-resistance via direct effects on Lyn ubiquitination and turnover that results in bursts of Lyn kinase activity, and identify c-cbl is a candidate E3 ubiquitin ligase. Furthermore, blockade of TGFβ signalling activity with the TGFβ receptor kinase inhibitor SB431542 significantly reduces Lyn turnover and activation, and subsequently enhances imatinib-mediated CML cell death in a proteasomal-dependent manner. Collectively, our data reveals novel co-operative mechanisms in CML involving TGFβ and Lyn kinase linked to proteasome function and ubiquitination, and thus supports therapeutic approaches that target TGFβ pathway activity as a strategy for overcoming imatinib-resistance in CML.
Magic Quadrant for Enterprise Mobility Management Suites

Enterprise mobility management (EMM) suites consist of policy and configuration management tools and a management overlay for applications and content intended for mobile devices based on smartphone OSs. They are an evolution from previous-generation mobile device management (MDM) products that lacked application and content management. IT organizations and service providers use EMM suites to deliver IT support to mobile end users and to maintain security policies.
Is One-time Pad History ?

Are one-time pads a thing of the past? There has been quite a bit discussion and some security and cryptography experts argue that one-time pad is no longer a system for today's needs, that it is impractical and creates enormous key distribution problems. They say that current computer algorithms provide enough security and public key schemes solve the problem of key distribution. That's all true. But there are some things they don't tell you.
Eosinophils Are Important for Protection, Immunoregulation and Pathology during Infection with Nematode Microfilariae

Eosinophil responses typify both allergic and parasitic helminth disease. In helminthic disease, the role of eosinophils can be both protective in immune responses and destructive in pathological responses. To investigate whether eosinophils are involved in both protection and pathology during filarial nematode infection, we explored the role of eosinophils and their granule proteins, eosinophil peroxidase (EPO) and major basic protein-1 (MBP-1), during infection with Brugia malayi microfilariae. Using eosinophil-deficient mice (PHIL), we further clarify the role of eosinophils in clearance of microfilariae during primary, but not challenge infection in vivo. Deletion of EPO or MBP-1 alone was insufficient to abrogate parasite clearance suggesting that either these molecules are redundant or eosinophils act indirectly in parasite clearance via augmentation of other protective responses. Absence of eosinophils increased mast cell recruitment, but not other cell types, into the broncho-alveolar lavage fluid during challenge infection. In addition absence of eosinophils or EPO alone, augmented parasite-induced IgE responses, as measured by ELISA, demonstrating that eosinophils are involved in regulation of IgE. Whole body plethysmography indicated that nematode-induced changes in airway physiology were reduced in challenge infection in the absence of eosinophils and also during primary infection in the absence of EPO alone. However lack of eosinophils or MBP-1 actually increased goblet cell mucus production. We did not find any major differences in cytokine responses in the absence of eosinophils, EPO or MBP-1. These results reveal that eosinophils actively participate in regulation of IgE and goblet cell mucus production via granule secretion during nematode-induced pathology and highlight their importance both as effector cells, as damage-inducing cells and as supervisory cells that shape both innate and adaptive immunity.
3-D microphysical model studies of Arctic denitrification: comparison with observations

Abstract. Simulations of Arctic denitrification using a 3-D chemistry-microphysics transport model are compared with observations for the winters 1994/95, 1996/97 and 1999/2000. The model of Denitrification by Lagrangian Particle Sedimentation (DLAPSE) couples the full chemical scheme of the 3-D chemical transport model, SLIMCAT, with a nitric acid trihydrate (NAT) growth and sedimentation scheme. We use observations from the Microwave Limb Sounder (MLS) and Improved Limb Atmospheric Sounder (ILAS) satellite instruments, the balloon-borne Michelsen Interferometer for Passive Atmospheric Sounding (MIPAS-B), and the in situ NOy instrument on-board the ER-2. As well as directly comparing model results with observations, we also assess the extent to which these observations are able to validate the modelling approach taken. For instance, in 1999/2000 the model captures the temporal development of denitrification observed by the ER-2 from late January into March. However, in this winter the vortex was already highly denitrified by late January so the observations do not provide a strong constraint on the modelled rate of denitrification. The model also reproduces the MLS observations of denitrification in early February 2000. In 1996/97 the model captures the timing and magnitude of denitrification as observed by ILAS, although the lack of observations north of ~67° N in the beginning of February make it difficult to constrain the actual timing of onset. The comparison for this winter does not support previous conclusions that denitrification must be caused by an ice-mediated process. In 1994/95 the model notably underestimates the magnitude of denitrification observed during a single balloon flight of the MIPAS-B instrument. Agreement between model and MLS HNO3 at 68 hPa in mid-February 1995 is significantly better. Sensitivity tests show that a 1.5 K overall decrease in vortex temperatures, or a factor 4 increase in assumed NAT nucleation rates, produce the best statistical fit to MLS observations. Both adjustments would be required to bring the model into agreement with the MIPAS-B observations. The agreement between the model and observations suggests that a NAT-only denitrification scheme (without ice), which was discounted by previous studies, must now be considered as one mechanism for the observed Arctic denitrification. The timing of onset and the rate of denitrification remain poorly constrained by the available observations.
Demand Based Data Replication in MANETs

Mobile Ad-hoc Network (MANET) is an emerging research area as it utilizes a diversity of applications. MANET is a self configuring network with dynamic topology. The network does not have any permanent infrastructure and the network can be formed on the fly. The mobile nodes in the network move frequently and the topology changes dynamically. So there is a chance of frequent network partitions. The node in one partition cannot access data items from a node in another partition. To improve data availability the data in the nodes should be replicated at various nodes. There are various data replication techniques available in MANETs. This paper focuses on the data replication by reserving storage space for the most demanded data item. This also includes the selection of a node and selection of a data item for replication. Thus the data availability can be improved since there are multiple replicas in the network and the possibility of finding one copy of data item is higher.
Robust Profile Verification Scheme Based On Ear Reference Coordinate System

In this paper, a novel profile verification scheme based on the ear, contour lines and feature points from head profile images is proposed. From the side image of a human head taken by a CCD camera, the contour line of the image is extracted by the simple filling method and morphological filtering. Based on the reference coordinate set by using ear images enrolled in the database a priori, the features of the contour line such as the tip of the nose, bottom of the nose, eye point and so on are extracted. The contour of the given image is divided into segments by utilizing the extracted feature points. The directional code of each segment is proposed and the length of the segment is computed for generating the feature vector. The verification of the given profile is performed by matching these feature vectors with those of the enrolled database. The experimental results show validity of the developed method for feature extraction and profile verification.
A Column-Row-Parallel ASIC architecture for 3D wearable / portable medical ultrasonic imaging

A Column-Row-Parallel ASIC architecture is proposed to enable 3D wearable / portable medical ultrasound. It offers linear-scaling interconnection, acquisition and programming time, while supporting rich functionality. High voltage MUX in Tx and specially sized source follower in Rx are used to implement parallelization for improved SNR. Fault-tolerant transceiver handles defective transducer elements to increase assembly yield and allow successful system demonstration.
Preparing programming teachers

INTRODUCTION Various groups concerned about the quality of computer progr armrting instruction have attempted to define what preparation a teacher of computer programming should have. Professional societies formed several task forces which recommended programs of study; several states have developed standards for certification in teaching computer courses; and colleges/universities have designed programs of study for preparing computer teachers. These programs, however, vary greatly in conteng amount of required coursework, and rigor. Most computer programming teachers still come from the ranks of inservice teachers and there is ongoing concern on how to prepare thk type of teacher to teach prograrnrning as well as problem solving.
An ERP study of Japanese causative cleft constructions in context

This study examined the processing of two types of Japanese causative cleft constructions (subject-gap vs. object-gap) by conducting an event-related brain potential (ERP) experiment to clarify the processing mechanism of long-distance dependencies. The results demonstrated that the subject-gap constructions elicited larger P600 effects compared with object-gap constructions. Based on these findings, we argue that the linear distance between the extracted argument (filler) and its original gap position is a crucial factor in determining the processing costs in Japanese causative cleft constructions.
A fast block-sorting algorithm for lossless data compression

Summary form only given. Introduces a new transformation for block-sorting data compression methods. The transformation is similar to the one presented by Burrows and Wheeler, but avoids the drawbacks of uncertain runtime and low performance with large blocks. The cost is a small compression loss and a slower back transformation. In addition to that it is well suited for hardware implementation. Typical applications include real-time data recording, fast communication lines, on the fly compression and any other task requiring high throughput. The difference between this transformation and the original block-sort transformation is that the original transformation sorts on unlimited context, whereas this transformation sorts on limited context (typically a few bytes) and uses the position in the input block to determine the sort order in the case of equal contexts.
In vitro anti-cancer activity of doxorubicin against human RNA helicase, DDX3

RNA helicase, DDX3 is a multifunctional enzyme and is known to be associated with several diseases like HIV progression, brain and breast cancer. Some of the ring expanded nucleoside compounds such as REN: NZ51, fused di imidazodiazepine ring (RK33), (Z)-3-(5- (3-bromo benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-N-(2- hydroxy phenyl) propanamide compound (FE15) have been documented to inhibit DDX3 helicase activity. However, synthesis of these drugs is limited to few research groups. Prevalence of literature study, we found that doxorubicin form strong hydrogen bond interactions with crystallized form of DDX3 using in-silico molecular docking approach. To evaluate the biological inhibitory action of doxorubicin, we performed the ATPase activity assay and anti-cancer activity using H357 cancer cell lines. Results showed that doxorubicin continually declined the inorganic phosphate (Pi) release and inhibited the ATP hydrolysis by directly interacting with DDX3. Anticancer activity was detected by MTT assay. The half maximal inhibitory concentrations of doxorubicin (IC50) for H357 cancer cell line is 50 μM and also doxorubicin significantly down regulated the expression of DDX3. Taken together, our results demonstrate, that inhibition of DDX3 expression by using doxorubicin can be used as an ideal drug candidate to treat DDX3 associated cancer disorder by interacting with unique amino acid residues (Thr 198) and common amino acid residues (Tyr 200 and Thr 201).
Dualities for Some Intuitionistic Modal Logics

We present a duality for the intuitionistic modal logic IK introduced by Fischer Servi in [8, 9]. Unlike other dualities for IK reported in the literature (see for example [13]), the dual structures of the duality presented here are ordered topological spaces endowed with just one extra relation, which is used to define the set-theoretic representation of both 2 and 3. Also, this duality naturally extends the definitions and techniques used by Fischer Servi in the proof of completeness for IK via canonical model construction [10]. We also give a parallel presentation of dualities for the intuitionistic modal logics IntK2 and IntK3. Finally, we turn to the intuitionistic modal logic MIPC, which is an axiomatic extension of IK, and we give a very natural characterization of the dual spaces for MIPC introduced in [2] as a subcategory of the category of the dual spaces for
The Pathophysiology of Secondary Hyperparathyroidism and the Consequences of Uncontrolled Mineral Metabolism in Chronic Kidney Disease: The Role of COSMOS

The development of secondary hyperparathyroidism (SHPT) is a common complication of chronic kidney disease. SHPT develops as a consequence of mineral metabolism disturbances and is characterized by elevated serum parathyroid hormone (PTH) and parathyroid hyperplasia. Evidence suggests that SHPT contributes to the development of vascular calcification and cardiovascular disease, as well as to the development of renal osteodystrophy. The elevated serum calcium, phosphorus, calcium–phosphorus product and PTH that accompany SHPT have been independently associated with an increased relative risk of mortality. Despite the danger that these risks represent, achieving control of mineral metabolism in SHPT is difficult. Recent evidence from the Current Management of Secondary Hyperparathyroidism: Multicentre Observational Study has shown that fewer than 1 in 10 haemodialysis patients simultaneously meet their National Kidney Foundation Kidney Disease Outcomes Quality Initiative targets for serum calcium, phosphorus, calcium–phosphorus product and PTH with standard treatments. There is therefore an urgent need for new strategies and novel pharmacologic therapies that improve control of mineral metabolism and PTH secretion in SHPT and thus reduce the mortality associated with this condition.
Fostering Parasocial Relationships with Celebrities on Social Media: Implications for Celebrity Endorsement

The purpose of this study was to explore the underlying mechanisms through which the use of social media affects endorser effectiveness. Based on theories related to parasocial relationships, self-disclosure, and celebrity endorsement, this study proposed a theoretical research model and empirically tested the model using online survey data collected from 400 Korean Wave fans in Singapore. The results showed that consumers’ parasocial interactions with celebrities though social media have a positive impact on celebrity endorsement. Specifically, we found that: (1) parasocial relationships mediated the relationships between social media interactions and source trustworthiness, (2) social media interactions influenced parasocial relationships via self-disclosure; and (3) source trustworthiness had a positive effect on brand credibility, which, in turn, led to purchase intention. Implications for research and practice are discussed.
Correlation between the molecular subtype of breast cancer and the in vitro adenosine triphosphate-based chemosensitivity assay

Purpose The empirical use of a chemotherapy regimen shows different results in individual breast cancer patient treatment. Recent studies showed the effectiveness of the adenosine triphosphate-based chemotherapy response assay (ATP-CRA). However, little is known about the correlation between chemosensitivity and breast cancer molecular subtypes. Therefore, we investigated whether the result of ATP-CRA is associated with a molecular subtype of breast cancer. Methods Two hundred eighty-seven patients diagnosed with breast cancer and receiving ATP-CRA at Mokdong Hospital, Ewha Womans University between September 2007 and December 2010 were enrolled in this study. Hormone receptor status, HER2/neu expression, and results of chemosensitivity tests of the patients was analyzed. Results In all of four subtypes, the combination of two agents showed significant higher mean cell death rate than a single agent. Within the breast cancer cell lines in this study, the range of chemosensitivity response was very wide and varied for each patient. For this reason, the molecular subtype of breast cancer is inconclusive in choosing an effective chemotherapeutic agent and in vitro chemosensitivity test, prior to therapy, could be a useful method for planning chemotherapy for each patient. Conclusion Chemosensitivity response to anticancer agents was found to vary depending on the individual breast cancer patients. The molecular subtype of breast cancer is inconclusive to choose the effective chemotherapeutic agent and the in vitro chemosensitivity test, prior to therapy, could be more useful for planning chemotherapy for each patient.
REVIEW of SOME MINIMUM-PROCESS SYNCHRONOUS CHECKPOINTING SCHEMES for MOBILE DISTRIBUTED SYSTEMS

The term Distributed Systems is used to describe a system with the following characteristics: i) it consists of several computers that do not share memory or a clock, ii) the computers communicate with each other by exchanging messages over a communication network, iii) each computer has its own memory and runs its own operating system. A mobile computing system is a distributed system where some of processes are running on mobile hosts (MHs), whose location in the network changes with time. The number of processes that take checkpoints is minimized to 1) avoid awakening of MHs in doze mode of operation, 2) minimize thrashing of MHs with checkpointing activity, 3) save limited battery life of MHs and low bandwidth of wireless channels. In minimum-process checkpointing protocols, some useless checkpoints are taken or blocking of processes takes place. To take a checkpoint, an MH has to transfer a large amount of checkpoint data to its local MSS over the wireless network. Since the wireless network has low bandwidth and MHs have low computation power, all-process checkpointing will waste the scarce resources of the mobile system on every checkpoint. Minimum-process coordinated checkpointing is a preferred approach for mobile distributed systems. In this paper, we discuss various existing minimum-process checkpointing protocols for mobile distributed systems. KeywordsCheckpointing algorithms; parallel & distributed computing; rollback recovery; fault-tolerant systems