Miracle-dz/UniFAR-FTUs huggingface dataset:
Tirapazamine, cisplatin, and radiation versus cisplatin and radiation for advanced squamous cell carcinoma of the head and neck (TROG 02.02, HeadSTART): a phase III trial of the Trans-Tasman Radiation Oncology Group.

PURPOSE Promising results in a randomized phase II trial with the hypoxic cytotoxin tirapazamine (TPZ) combined with cisplatin (CIS) and radiation led to this phase III trial. PATIENTS AND METHODS Patients with previously untreated stage III or IV (excluding T1-2N1 and M1) squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx were randomly assigned to receive definitive radiotherapy (70 Gy in 7 weeks) concurrently with either CIS (100 mg/m(2)) on day 1 of weeks 1, 4, and 7 or CIS (75 mg/m(2)) plus TPZ (290 mg/m(2)/d) on day 1 of weeks 1, 4, and 7 and TPZ alone (160 mg/m(2)/d) on days 1, 3, and 5 of weeks 2 and 3 (TPZ/CIS). The primary end point was overall survival (OS). The planned sample size was 850, estimated to result in 334 deaths, which would provide 90% power to detect a difference in 2-year survival rates of 60% v 70% for CIS versus TPZ/CIS, respectively (hazard ratio = 0.69). RESULTS Eight hundred sixty-one patients were accrued from 89 sites in 16 countries. In an intent-to-treat analysis, the 2-year OS rates were 65.7% for CIS and 66.2% for TPZ/CIS (TPZ/CIS--CIS: 95% CI, -5.9% to 6.9%). There were no significant differences in failure-free survival, time to locoregional failure, or quality of life as measured by Functional Assessment of Cancer Therapy-Head and Neck. CONCLUSIONS We found no evidence that the addition of TPZ to chemoradiotherapy, in patients with advanced head and neck cancer not selected for the presence of hypoxia, improves OS.
Graph based semi-supervised classification via capped l2, 1-norm regularized dictionary learning

During the past decade, graph-based semi-supervised learning has become one of the most important research areas in machine learning and artificial intelligence community. In this paper, we propose a Capped l2,1-Norm Regularized Dictionary Learning to construct the graph for semi-supervised learning (SSL). The new sparse coding is robust to the outliers and insensitive to noise. Then, the developed graph construction can better characterize the geometrical structure of data mainfold and be utilized for efficient graph based SSL. the proposed SSL methods can also be easily extended to deal with out-of-sample data. Simulation results show that the proposed method can achieve better performance compared with other state-of-the-art graph based SSL methods.
An Examination of the Meanings of Trademarks and Their Graphic Elements.

A study used semiotics to examine the graphic elements within corporate trademarks. The trademarks from 247 "Fortune" 500 corporations were placed into 86 different categories of graphic elements intended to connote 14 different qualities. Subjects, 40 college students and 61 business professionals, evaluated 9 sets of 12 trademarks in terms of their intended meanings. Results indicated that in seven of the nine cases, the trademarks did connote their intended meanings. Findings suggest support for the premise that there are semantic meanings to visual phonemes. Findings also bolster the idea that the image is a valid design for communication studies. (Contains 39 references and 1 table of data.) (RS) *********************************************************************** Reproductions supplied by EDRS are the best that can be made from the original document. *********************************************************************** An Examination of the Meanings of Trademarks and Their Graphic Elements University of Alabama Edward A. Johnson -PERMISSION TO REPRODUCE THIS MATERIAL HAS BEEN GRANTED BY
Secure Robust Ergodic Uplink Resource Allocation in Relay-Assisted Cognitive Radio Networks

We investigate the ergodic uplink resource allocation problem for secure communication in relay-assisted orthogonal frequency-division multiple access (OFDMA)-based cognitive radio networks (CRNs) in the presence of a set of passive eavesdroppers where relay nodes assist the legitimate users to transmit their messages. Previous works have commonly assumed the availability of channel state information (CSI) for this type of problems. However, due to the decentralized nature of CRNs and hidden activities of eavesdroppers, the assumption of availability of exact values of CSI is not realistic. In this paper, we consider uncertainty on the estimated values of CSI between different transmitters and receivers, e.g., CSI between each legitimate transmitter and its corresponding receiver and CSI of each legitimate user and each eavesdropper. We utilize the worst-case robust formulation to find power and sub-carrier allocations in such a way that under the worst condition of error, the regulatory constraints imposed to CRN are satisfied and the secrecy rate of each secondary legitimate user is stabilized. It is well known that the robust approaches impose a high computational complexity to the system and reduce the system performance as they conservatively consider the error in the maximum extent. We demonstrate how the robust formulation can be significantly simplified and tradeoff parameters can be introduced to moderate the effect of the worst-case approach. Simulation results are provided to demonstrate the performance of CRNs for different uncertain system parameters.
KEIDERLING correlations to and predictions of protein secondary structure vibrational and electronic circular dichroism spectra in terms of Comparison of and limits of accuracy for statistical analyses of data

This work provides a systematic comparison of vibrational CD (VCD) and electronic CD (ECD) methods for spectral prediction of secondary structure. The VCD and ECD data are simplified to a small set of spectral parameters using the principal component method of factor analysis (PC/FA). Regression fits of these parameters are made to the X-ray-determined fractional components (FC) of secondary structure. Predictive capability is determined by computing structures for proteins sequentially left out of the regression. All possible combinations of PC/FA spectral parameters (coefficients) were used to form a full set of restricted multiple regressions with the FC values, both independently for each spectral data set as well as for the two VCD sets and all the data grouped together. The complete search over all possible combinations of spectral parameters for different types of spectral data is a new feature of this study, and the focus on prediction is the strength of this approach. The PC/FA method was found to be stable in detail to expansion of the training set. Coupling amide I1 to amide I' parameters reduced the standard deviations of the VCD regression relationships, and combining VCD and ECD data led to the best fits. Prediction results had a minimum error when dependent on relatively few spectral coefficients. Such a limited dependence on spectral variation is the key finding of this work, which has ramifications for previous studies as well as suggests future directions for spectral analysis of structure. The best ECD prediction for helix and sheet uses only one parameter, the coefficient of the first subspectrum. With VCD, the b st predictions sample coefficients of both the amide I' and I1 bands, but error is optimized using only a few coefficients. In this respect, ECD is more accurate than VCD for a-helix, and the combined VCD (amide I '+II) predicts the P-sheet component better than does ECD. Combining VCD and ECD data sets yields exceptionally good predictions by utilizing the strengths of each. However, the residual error, its distribution, and, most importantly, the lack of dependence of the method on many of the significant components derived from the spectra leads to the conclusion that the heterogeneity of protein structure is a fundamental limitation to the use of such spectral analysis methods. The underutilization of these data for prediction of secondary structure suggests spectral data could predict a more detailed descriptor.
High efficiency fly-back converter using resistance compression network

In applications like photovoltaic systems the low voltage output of solar panels ( typically 12 Volts) has to be boosted to high voltage ( typically up to 400V) and then inverted to 230 V standard ac supply. This project aims at developing a Fly back based high step up dc-dc converter with high voltage step-up ratios. In a fly back converter, when the current ramps up in the primary, energy is built up in the transformer core. When the MOSFET switches off, this energy is dumped into the secondary, allowing current to flow in the secondary, so the primary current collapses immediately to zero. This causes an immediate rise in current in the secondary, after which, the current in the secondary ramps down linearly as it discharges, supplying energy to the load. The current in the secondary when the MOSFET switches off, is proportional to the peak in the primary, and is determined by the transformer turns ratio. Experimental results from the prototype show that over 97% efficiency is maintained across an input voltage of 40 V with an output voltage of 420 V. These experimental results demonstrate the effectiveness of the proposed design.
A Multi-prover Interactive Proof for NEXP Sound against Entangled Provers

We prove a strong limitation on the ability of entangled provers to collude in a multiplayer game. Our main result is the first nontrivial lower bound on the class MIP* of languages having multi-prover interactive proofs with entangled provers, namely MIP* contains NEXP, the class of languages decidable in non-deterministic exponential time. While Babai, Fort now, and Lund (Computational Complexity 1991) proved the celebrated equality MIP = NEXP in the absence of entanglement, ever since the introduction of the class MIP* it was open whether shared entanglement between the provers could weaken or strengthen the computational power of multi-prover interactive proofs. Our result shows that it does not weaken their computational power: MIP* contains MIP. At the heart of our result is a proof that Babai, Fort now, and Lund's multilinearity test is sound even in the presence of entanglement between the provers, and our analysis of this test could be of independent interest. As a byproduct we show that the correlations produced by any entangled strategy which succeeds in the multilinearity test with high probability can always be closely approximated using shared randomness alone.
Multiple rows of cells behind an epithelial wound edge extend cryptic lamellipodia to collectively drive cell-sheet movement

The mechanism by which epithelial, endothelial and other strongly cell-cell adhesive cells migrate collectively as continuous sheets is not clear, even though this process is crucial for embryonic development and tissue repair in virtually all multicellular animals. Wound closure in Madin-Darby canine kidney (MDCK) epithelial cell monolayers involves Rac GTPase-dependent migration of cells both at and behind the wound edge. We report here for the first time that cells behind the margin of wounded MDCK cell monolayers, even hundreds of microns from the edge, extend `cryptic' lamellipodia against the substratum beneath cells in front of them, toward the wound, as determined by confocal, two-photon and transmission electron microscopy. These so-called submarginal cells nevertheless strictly maintain their more apical cell-cell contacts when they migrate as part of a coherent cell sheet, hiding their basal protrusions from conventional microscopy. The submarginal protrusions display the hallmarks of traditional lamellipodia based on morphology and dynamics. Cells behind the margin therefore actively crawl, instead of just moving passively when cells at the margin pull on them. The rate of migration is inversely proportional to the distance from the margin, and cells move co-ordinately, yet still in part autonomously, toward the wound area. We also clarify the ancillary role played by nonprotrusive contractile actin bundles that assemble in a Rho GTPase-dependent manner at the margin after wounding. In addition, some cell proliferation occurs at a delay after wounding but does not contribute to closure. Instead, it apparently serves to replace damaged cells so that intact spread cells can revert to their normal cuboidal morphology and the original cell density of the unbroken sheet can be restored.
Homotopy Rinehart cohomology of homotopy Lie-Rinehart pairs

We dene homotopy Lie-Rinehart pairs and the associated homo- topy Rinehart algebra in the context of coalgebras. We dene homotopy Lie-Rinehart resolutions and present conditions under which the asso- ciated homotopy Rinehart algebra is a cohomological model for the Rinehart algebra of the resolved Lie-Rinehart pair.
Automatic inference of mental states from spontaneous facial expressions

Human face is a display of mental states that reflect the true feelings of a person. In this paper, we propose a framework for the video analysis of spontaneous facial expressions using an automatic facial emotion recognition system. Regional Hidden Markov Models (RHMMs) are created to describe the states of facial attributes for eyebrows, eyes, and mouth regions registered in a video sequence. The performance results reported in the paper show that the proposed technique outperforms the designated HMM for each emotion type [1, 2] tested with the Cohn-Kanade database for the person-independent case. More importantly, we used the proposed system to infer the mental states of a person based on spontaneous facial expressions. Merit of the proposed system is validated with human based evaluations.
Low-crosstalk waveguide crossing based on 1×1 MMI structure of silicon-wire waveguide

Waveguide crossing based on a tilted multimode-interference (MMI) structure in high-index-contrast silicon wire is reported. For low crosstalk and low loss, crossing angle of MMIs is optimized. The measured crosstalk with the optimal crossing angle of 110° is -44 dB at wavelength of 1550 nm. This corresponds to improvement by more than 14 dB from previously reported crosstalk with 90°-crossings of MMIs.
Information Content of Financial Reporting and Information Value of Financial News - an Opinion Analytics Approach

This study investigates the impact of the quality of disclosures of financial reports of the listed firms in Taiwan under her first full adoption of International Financial Reporting Standards (IFRS) in 2013. We select the semi-annual reports of firms in the three main industry sectors of high technology, financial service, and biotechnology representing 80% of the capital market in the first year of mandatory adoption. The dictionary of financial reporting is developed according to opinion mining and sentiment analysis. In contrast to prior studies, we explore the gap analytics between financial reporting and financial news to explore whether the disclosure quality is related with the adoption of IFRS. Results are promising and show that the disclosures have relationship with the IFRS first adoption.
Photoperiodic regulation of hamster testis: circadian sensitivity to the effects of light.

The mechanism of discrimination of daylength and the effect of light on the reproductive system were investigated in male golden hamsters (Mesocricetus auratus). The photoperiodic response of hamsters is not determined by the absolute amount of light or of darkness (on each day) or the ratio of light:dark. Rather, a circadian rhythm of photosensitivity determines whether light will stimulate the hypothaIamo-hypop iysio-testicular axis. Hamsters were exposed to cycles of 6 h of light combined with varying durations of darkness to generate period lengths of 24, 36, 48 and 60 h. Six h of light presented daily (LD 6:18) or every 2 days (LD 6:42) were not capable of maintaining the testes and seminal vesicles in a mature state. On the other hand, 6 h of light presented every 1#{189} days (LD 6:30) or every 2#{189} days (LD 6:54) were interpreted as “long days” by hamsters, and testes, and seminal vesicles were maintained at relatively high levels for up to 89 days. Essentially the same pattern of response was observed when hamsters with regressed testes and seminal vesicles were exposed to the same four light cycles. Considerable increase in organ weights (recrudescence) occurred in animals exposed to LD 6:30 and LD 6:54 while the organ weights of those exposed to LD 6:18 and LD 6:42 increased much less (LD 6:18) or not at all (LD 6:42). The photoperiodic response of the reproductive system during two widely separated phases of the annual testicular cycle in the hamster depends primarily on the position of light relative to the circadian system. BIOLOGY OF REPRODUCTION 13, 329-339
LIFE EXPERIENCES, DEVELOPMENT AND CHILDHOOD PSYCHOPATHOLOGY

Social conditions - social experiences and development adaptation, adjustment and the family peer relations and friendship difficulties community environments - war and disaster personal disposition - monoamines, immunity and social adversity arousal, emotions and temperment cognition, coping and behaviour psychopathology - life events, difficulties and psychiatric disorders models of stress and psychopathology social adversity and public policy clinical issues and interventions.
Characteristics and outcomes of polymicrobial bloodstream infections in the emergency department: A matched case-control study.

OBJECTIVES Polymicrobial bloodstream infection (BSI) is a critical condition and has been increasingly reported; however, the authors were unable to find an emergency department (ED) patient-based study in the literature. METHODS A retrospective matched case-control study with a ratio of 1:3 among patients with polymicrobial BSIs in an ED was conducted. The case group was patients aged > 16 years with polymicrobial BSIs. Patients matched for age and sex with monomicrobial BSIs were sampled as the control group. Demographic information, underlying conditions, microbiologic data, and outcomes were collected for further analysis. RESULTS From January 2005 to December 2007, a total of 112 episodes of polymicrobial BSIs among 109 patients were included. Two pathogens were isolated among 87 (77.7%) episodes and three were found among 25 (22.3%) episodes. A history of hospitalization within 90 days was an independent risk factor for polymicrobial BSIs (p = 0.003). Intraabdominal infection (p < 0.001) and respiratory tract infection (p = 0.017) were more likely to be associated with polymicrobial BSIs. Gram-negative and Gram-positive bacteria were documented in 95.5 and 46.4% episodes of polymicrobial BSIs, respectively. Inappropriate antimicrobial treatment was observed in 53.6% of polymicrobial BSIs, but only accounted for 23.8% of monomicrobial BSIs (p < 0.001). The overall 30-day mortality rate of the polymicrobial group was significantly higher than those with monomicrobial BSIs (30.3 and 11.6%, respectively; p < 0.001). CONCLUSIONS Patients with polymicrobial BSIs had a high mortality rate. Acknowledgment of the clinical and microbiologic characteristics and recognition of patients at risk for polymicrobial BSIs are critical in EDs.
An outbreak of colonization with linezolid-resistant Staphylococcus epidermidis in an intensive therapy unit.

OBJECTIVES To report an outbreak of colonization with linezolid-resistant Staphylococcus epidermidis in an intensive therapy unit (ITU). METHODS An outbreak of colonization with linezolid-resistant S. epidermidis affecting 16 patients in an ITU was investigated using PFGE. Environmental and staff screening was carried out as part of the investigation. Usage of linezolid in the hospital and in the ITU was reviewed. Resistant strains were screened for the presence of the G2576T mutation using PCR-RFLP genotyping. The interventions made to control the outbreak were restriction of linezolid prescription and specific infection control measures, including isolation of colonized patients and increased environmental cleaning. RESULTS Linezolid-resistant S. epidermidis strains from the 16 colonized patients were genetically related. The same strain was also cultured from environmental samples in the ITU. An increase in linezolid usage in the hospital and in the ITU occurred in the 6 months prior to the emergence of the resistant strain. Infection control measures and restriction of linezolid prescription controlled the outbreak. All resistant isolates contained the G2576T mutation. CONCLUSIONS An outbreak of colonization with linezolid-resistant S. epidermidis occurred in the ITU in our institution. The resistant strain colonized the environment and probably spread from patient to patient. The outbreak was associated with an increase in the linezolid usage in the ITU and in the institution as a whole. Restriction of linezolid usage and infection control measures were introduced to control the outbreak. The emergence of linezolid resistance in S. epidermidis has implications for the use of linezolid as a therapeutic agent.
Escholarship@umms Program in Gene Function and Expression Publications and Presentations Program in Gene Function and Expression Transcriptional Regulation of Vegf-a by the Unfolded Protein Response Pathway Repository Citation Transcriptional Regulation of Vegf-a by the Unfolded Protein Response Pat

"Transcriptional regulation of VEGF-A by the unfolded protein response pathway" (2010). Program in Gene Function and Expression Publications and Presentations. Paper 31. Abstract Background: Angiogenesis is crucial to many physiological and pathological processes including development and cancer cell survival. Vascular endothelial growth factor-A (VEGFA) is the predominant mediator of angiogenesis in the VEGF family. During development, adverse environmental conditions like nutrient deprivation, hypoxia and increased protein secretion occur. IRE1a, PERK, and ATF6a, master regulators of the unfolded protein response (UPR), are activated under these conditions and are proposed to have a role in mediating angiogenesis.
Glycolytic and oxidative metabolism in relation to retinal function

Measurements of lactate production and ATP concentration in superfused rat retinas were compared with extracellular photoreceptor potentials (Fast PIII). The effect of glucose concentration, oxygen tension, metabolic inhibition, and light were studied. Optimal conditions were achieved with 5-20 mM glucose and oxygen. The isolated retina had a high rate of lactate production and maintained the ATP content of a freshly excised retina, and Fast PIII potentials were similar to in vivo recordings. Small (less than 10%) decreases in aerobic and anaerobic lactate production were observed after illumination of dark- adapted retinas. There were no significant differences in ATP content in dark- and light-adapted retinas. In glucose-free medium, lactate production ceased, and the amplitude of Fast PIII and the level of ATP declined, but the rates of decline were slower in oxygen than in nitrogen. ATP levels were reduced and the amplitude of Fast PIII decreased when respiration was inhibited, and these changes were dependent on glucose concentration. Neither glycolysis alone nor Krebs cycle activity alone maintained the superfused rat retina at an optimal level. Retinal lactate production and utilization of ATP were inhibited by ouabain. Mannose but not galactose or fructose produced lactate and maintained ATP content and Fast PIII. Iodoacetate blocked lactate production and Fast PIII and depleted the retina of ATP. Pyruvate, lactate, and glutamine maintained ATP content and Fast PIII reasonably well (greater than 50%) in the absence of glucose, even in the presence of iodoacetate. addition of glucose, mannose, or 2-deoxyglucose to medium containing pyruvate and iodoacetate abolished Fast PIII and depleted the retina of its ATP. It is suggested that the deleterious effects of these three sugars depend upon their cellular uptake and phosphorylation during the blockade of glycolysis by iodoacetate.