Miracle-dz/UniFAR-FTUs huggingface dataset:
Aripiprazole and Dehydroaripiprazole Plasma Concentrations and Clinical Responses in Patients With Schizophrenia

Aripiprazole is widely used to treat schizophrenia. Plasma levels of aripiprazole and its active metabolite dehydroaripiprazole and their clinical responses in patients were explored. Forty-five (male/female: 19/26) patients with schizophrenia were treated with aripiprazole after a washout period of at least 3 days. There was no concomitant psychotropic except benzodiazepines for insomnia. The Positive and Negative Syndrome Scale (PANSS) was used to measure the clinical response at baseline and at weeks 2, 4, and 6. Blood was drawn at week 6 to measure the plasma concentrations of aripiprazole and dehydroaripiprazole. Patients with a PANSS score that decreased by more than 20% were defined as responders after 6 weeks of treatment. There was no difference in baseline PANSS scores or the daily dosage used between responders (n = 28) and nonresponders (n = 17) (15.0 ± 5.9 vs 12.9 ± 6.9 mg, respectively; P = 0.203). The responders showed a trend toward a higher plasma concentration of aripiprazole than nonresponders (234.4 ± 156.7 vs 163.5 ± 77.2 ng/mL, respectively; P = 0.117) and a significantly higher plasma concentration of dehydroaripiprazole (101.6 ± 58.0 vs 66.0 ± 48.4, respectively; P = 0.023). Higher plasma concentrations of aripiprazole and its active metabolite dehydroaripiprazole were noted in responders than nonresponders. Compared with Western patients, Oriental patients had higher plasma concentrations of aripiprazole and dehydroaripiprazole at the same dose. We suggest that therapeutic drug monitoring of aripiprazole will help improve the response in clinical practice.
Extracting Keywords of Web Users' Interests and Visualizing their Routine Visits

Analyzing users' Web log data and extracting their interests of Web-watching behaviors are important and challenging research topics of Web usage mining. Users visit their favorite sites and sometimes search new sites by performing keyword search on search engines. Users' Web-watching behaviors can be regarded as a graph since visited Web sites and entered search keywords are connected with each other in a time sequence. We call this graph as a site-keyword graph. This paper describes a method for clarifying users' interests based on an analysis of the site-keyword graph. The method is for extracting subgraphs representing users' routine visit from a site-keyword graph which is generated from augmented Web audience measurement data (Web log data). Experimental result shows that our new method succeeds in finding subgraphs which contain most of users' interested sites
Psychometric prediction of PTSD among POW survivors.

Reports indicate a high prevalence of posttraumatic stress disorder (PTSD) in former World War II (WWII) and Korean Conflict prisoners of war (POWs), but little information is available on the utility of psychometric instruments for assessment of PTSD among survivors of severe trauma. This study determined the extent to which a psychometric battery, distinguished PTSD and non-PTSD diagnosed groups
The Narrative Quality of Experience

HE forms of cultural expression are not historical accidents. They are not products of culture, much less products of individual choice and contrivance, although actual cultural expressions are to some extent both. The way people speak, dance, build, dream, embellish, is to be sure always culturally particular: it bears the imprint of a time and a place. A people speaks a particular language, not the same as that spoken in another land nor quite the same as that spoken by their fathers, and each person adapts it with some originality to his own use. But the fact that people speak some language is no historical accident. It is a necessary mark of being human, i.e., being capable of having a history. That is also true of other persistent forms of cultural expression. They are the conditions of historical existence; their expressions are moulded in the historical process itself into definite products of particular cultures. I do not know how to go about proving any such grandiose thesis. To me, I confess, it seems self-evident, in the sense that once the appropriate distinctions are made it becomes obvious. Be that as it may, I propose here to illustrate the point in relation to storytelling, which I take to be one of the most important cultural expressions. I want to argue that the formal quality of experience through time is inherently narrative. ' I introduce this thesis by briefly posing another, to which it is intimately related: The style of action through time is inherently musical. The relation of the two theses can be stated in an equation of positively luminous simplicity: Narrative quality is to experience as musical style is to action. And action and experience interpenetrate. Let us see about that.
Maritime ATR using Classifier Combination and High Resolution Range Profiles

A maritime automatic target recognition system is developed that performs ship classification using one-dimensional high resolution range profiles. Five physically based features are defined and are extracted from both VV and HH polarizations resulting in a 10-dimensional feature vector. A nonlinear classifier combination approach involving a neural network combiner along with three individual classifiers (Bayes, nearest neighbor, and neural network) is proposed. A decision confidence measure based on the classifier discriminants is developed using a nonparametric estimation approach. The confidence measure enables the system to reject samples that have a low decision confidence. The performance of the proposed neural network based combination is compared with individual classifiers and a number of other combination rules. The results show that this combination can provide high recognition accuracy along with a high probability of declaration. The performance in the presence of samples from not-before-seen classes is also investigated. A new nearest neighbor confidence thresholding approach is developed to aid the neural network combiner in rejecting these samples.
A semi-deterministic approach for modelling of urban travel demand

This paper presents a methodology to construct travel related activity schedules for individuals in a synthetic population. The resulting list of activity schedules are designed as an input into a micro-simulator for urban transport dynamics analysis. The methodology involves two main steps. The first step generates a synthetic population based on census data sourced from the Australian Bureau of Statistics (ABS). The second step assigns individuals in the synthetic population activity schedules using Household Travel Survey (HTS) data related to the geographical area of interest (in this case, the Sydney Greater Metropolitan area). Each individual is assigned an ordered set of trips, travel purpose, travel mode, departure time and estimated trip time. The significance of the methodology is twofold in that it generates a synthetic population aligned with area demographics, as well as generating activity schedules that realistically represent how the population uses existing transport infrastructure. The methodology also preserves the inter-dependencies (in terms of the sequence, travel times and purpose of trips) of individual's daily trips, in contrast to many trip generators for transport micro-simulation purposes. A case study of Randwick area in southern Sydney is presented where the proposed methodology is applied. Case study data is validated against real world results and the scalability and applicability to other urban areas are discussed.
Weight two motivic cohomology of classifying spaces for semisimple groups

Let $f:X\to Y$ be a torsor for a semisimple group $G$ with $Y$ a smooth and geometrically irreducible variety over an arbitrary field. We relate the \'etale motivic cohomology of weight two for $X$, $Y$ and $G$. We also compute the \'etale motivic cohomology groups of degree at most $4$ for the classifying space of $G$. This result was used in an another work by the author for the computation of the group of degree $3$ cohomological invariants of semisimple groups with coefficients in ${\Bbb Q}/{\Bbb Z}(2)$.
DAS181 Inhibits H5N1 Influenza Virus Infection of Human Lung Tissues

ABSTRACT DAS181 is a novel candidate therapeutic agent against influenza virus which functions via the mechanism of removing the virus receptor, sialic acid (Sia), from the adjacent glycan structures. DAS181 and its analogues have previously been shown to be potently active against multiple strains of seasonal and avian influenza virus strains in several experimental models, including cell lines, mice, and ferrets. Here we demonstrate that DAS181 treatment leads to desialylation of both α2-6-linked and α2-3-linked Sia in ex vivo human lung tissue culture and primary pneumocytes. DAS181 treatment also effectively protects human lung tissue and pneumocytes against the highly pathogenic avian influenza virus H5N1 (A/Vietnam/3046/2004). Two doses of DAS181 treatment given 12 h apart were sufficient to block H5N1 infection in the ex vivo lung tissue culture. These findings support the potential value of DAS181 as a broad-spectrum therapeutic agent against influenza viruses, especially H5N1.
Word-of-Mouth as Self-Enhancement

In this research we predict and demonstrate that consumers' propensities to generate word-of-mouth (WOM) is affected by their motivation to self-enhance, that is, to seek experiences that bolster the self-concept. Data from three experiments and an empirical analysis of real-world WOM indicate that self-described consumer experts demonstrate a positivity bias, generating more WOM regarding their satisfying versus their dissatisfying experiences. Importantly, this pattern intensifies when expertise is salient, and it only persists when the experience outcome is attributable to their expertise. In addition to demonstrating the effects and implications of self-enhancement in the WOM context, these insights may partially explain the inconsistencies in previous research regarding the ratio of positive versus negative WOM.
Barorezeptorstimulation bei therapierefraktärem Bluthochdruck

Zusammenfassung Therapierefraktärer Bluthochdruck liegt vor, wenn eine Behandlung mit mindestens drei Antihypertensiva in ausreichender Dosierung, von denen eines ein Diuretikum sein sollte, den Blutdruck nicht kontrolliert und keine sekundären Hypertonieursachen vorliegen. Für medikamentös austherapierte Patienten und bei hohem kardiovaskulärem Risiko wurde die elektrische Baroreflexstimulation entwickelt. Dabei soll dem Gehirn mittels einer elektrischen Stimulation von Barorezeptoren vorgegaukelt werden, dass der Blutdruck ansteigt, um so eine reflektorische Reduktion der Sympathikusaktivität zu erzielen. Tatsächlich bewirkt eine elektrische Stimulation des Karotissinus eine akute Reduktion von mikroneurografisch abgeleiteter Sympathikusaktivität und Blutdruck bei Patienten mit refraktärem Bluthochdruck. Gleichzeitig reduziert sich die Reninkonzentration im venösen Blut, was für eine Hemmung der renalen Sympathikusaktivität spricht. Die physiologische Baroreflexregulation von Herzfrequenz und Sympathikus bleibt erhalten. Erste Langzeiterfahrungen in klinischen Studien sprechen dafür, dass mittels Baroreflexstimulation bei einem Teil der Patienten eine langfristige Blutdrucksenkung erreicht werden kann. Die Daten aus kontrollierten klinischen Studien sind jedoch nicht hinreichend, um einen breiteren klinischen Einsatz zu rechtfertigen.
Evaluation of the Endothelial Cell Density and the Central Corneal Thickness in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma

Purpose. Evaluation of central corneal thickness (CCT) and endothelial cell density (ECD) in patients with senile cataract and coexisting pseudoexfoliation (PEX) syndrome with glaucoma (PEXG) and without glaucoma using specular microscopy. Participants and Methods. The study included 122 patients (217 eyes). In this group of patients we identified 133 eyes with PEX syndrome (65 with glaucoma, 68 without glaucoma) and 84 eyes without PEX syndrome. ECD and CCT were measured in each eye by specular microscopy. Results. ECD in eyes with PEX syndrome without glaucoma (2297 ± 359 cell/mm2) and in eyes with PEXG (2241 ± 363 cell/mm2) was lower than in the control group (2503 ± 262 cell/mm2) (P < 0.001). CCT in eyes with PEXG (508.2 ± 32.6 μm) was thinner than in eyes with PEX syndrome without glaucoma (529.7 ± 30.3 μm) and control group (527.7 ± 29.4 μm) (P < 0.001). Conclusions. This research shows that in eyes with PEX syndrome, both with and without glaucoma, ECD was statistically significantly lower than in the control group. In patients with PEXG, CCT was statistically significantly thinner than in the PEX syndrome and control group.
[Structural features of macular eyes of preschoolers born preterm: analysis by optical coherence tomography, and indirect ophthalmoscopy].

PURPOSE Compare the retinal structure of the macula and fovea among premature infants with retinopathy of prematurity (ROP) stages II and III post treatment, premature infants with ROP stages II and III with spontaneous regression and premature infants without ROP, through optical coherence tomography (OCT) and binocular indirect ophthalmoscopy (BIO) examinations. METHODS Cross-sectional observational and not-blinded study. There were included premature infants born between 06/1992 and 06/2006 and examined between 06/2009 and 12/2010; gestational age less than or equal to 32 weeks and birth weight less than or equal to 1,599 g; with a minimum of three visits during the selection period; without retinopathy of prematurity, or with the diagnosis of ROP stages II or III in at least one eye with spontaneous regression or after ROP treatment; maximum of six months of chronological age for the first examination at the service; minimal chronological age of four years old in the reassessment period. There were excluded premature infants who did not attend or did not have clinical conditions for the reassessment examination. The premature infants were divided into three groups: G1 - with ROP post-treatment; G2 - with ROP post-spontaneous regression; and G3 - without ROP. The exams performed were BIO and OCT. RESULTS Twenty-four premature infants (48 eyes) presented the criteria required for the research, chronological age ranging from 5 to 6 years. At BIO, there was a statistically significant difference for the presence of alterations in the retina of premature infants from group G1. However these changes corresponded to the cicatricial lesions left by the ROP treatment, without visible impairment to the macular region. At OCT there were statistically significant differences for the greatest foveal thickness between premature infants from groups G1 and G2. Considering the left eye, there was no statistically significant difference related to the thickness of the fovea between G1 and G3. There was no difference among the three groups studied in relation to the changes of the retinal layers at OCT. CONCLUSION Premature infants with ROP post-treatment showed foveal thickness greater than premature infants with ROP post-spontaneous regression; and foveal thickness similar to premature infants without ROP in relation to assessment of the left eye. Regarding the changes of the retinal layers detected at OCT, the three groups were similar, without expression of difference for the treated group in this study.
PREDIKSI TOPIK PENELITIAN MENGGUNAKAN KOMBINASI ANTARA SUPPORT VECTOR REGRESSION DAN KURVA LOGISTIK

Prediksi topik penelitian diperlukan terutama oleh pengambil kebijakan misalnya untuk menentukan tema penelitian yang akan datang. Analisis terhadap tren topik penelitian dengan menggunakan pendekatan numerik berdasarkan publikasi ilmiah dan/atau paten telah dilakukan dalam beberapa peneliti sebelumnya dengan menghitung frekuensi kata yang sama dalam beberapa dokumen untuk mengelompokkan topik. Sementara itu, analisis time series dilakukan peneliti lainnya dengan menggunakan teknik statistik, pembelajaran mesin dan kurva logistik untuk domain di luar topik penelitian. Dalam penelitian ini, akan dilakukan analisis time series untuk memprediksi topik penelitian dengan menggabungkan teknik pembelajaran mesin, yakni Support Vector Regression (SVR), dan kurva logistik, dengan asumsi bahwa terdapat batas atas terhadap siklus pertumbuhan setiap topik penelitian. Data yang digunakan dalam studi ini adalah data laporan penelitian dari situs Garuda selama kurun waktu 16 tahun. Selain itu, sebagai acuan, digunakan juga data dari ITU (International Telecommunication Unit) yang serupa dengan yang digunakan oleh peneliti sebelumnya. Hasil eksperimen menunjukkan bahwa kombinasi antara SVR dan kurva logistik dapat meningkatkan akurasi prediksi. Selain itu, dari data yang digunakan, dapat diketahui bahwa topik penelitian yang pertumbuhannya cukup tinggi adalah Medicine, Biology dan Social pathology and public walfare.
Complement C4B protein in schizophrenia

Partial and/or complete deficiency of the complement protein C4 is associated with autoimmune and infectious diseases. Infectious or autoimmune processes may have a role in schizophrenia. Previous reports suggest abnormalities in the complement C4B isotype in schizophrenia and other mental disorders. We assessed C4A and C4B isotypes and serum C4B protein concentration in Armenian schizophrenic patients. Although there was no difference in frequency of C4BQ0, C4B serum protein level was significantly decreased in the schizophrenic patients compared with healthy controls.
Engineering the anthocyanin regulatory complex of strawberry (Fragaria vesca)

The woodland strawberry, Fragaria vesca is a model fruit for a number of rosaceous crops. We have engineered altered concentrations of anthocyanin in F. vesca, to determine the impact on plant growth and fruit quality. Anthocyanin concentrations were significantly increased by over-expression or decreased by knock-down of the R2R3 MYB activator, MYB10. In contrast, a potential bHLH partner for MYB10 (bHLH33) did not affect the anthocyanin pathway when knocked down using RNAi constructs. Metabolic analysis of fruits revealed that, of all the polyphenolics surveyed, only cyanidin, and pelargonidin glucoside, and coumaryl hexose were significantly affected by over-expression and knock down of MYB10. Using the F. vesca genome sequence, members of the MYB, bHLH, and WD40 families were examined. Global analysis of gene expression and targeted qPCR analysis of biosynthetic genes and regulators confirmed the effects of altering MYB10 expression, as well as the knock-down of bHLH33. Other members of the MYB transcription factor family were affected by the transgenes. Transient expression of strawberry genes in Nicotiana benthamiana revealed that MYB10 can auto-regulate itself, and potential repressors of MYB10. In tobacco, MYB10's activation of biosynthetic steps is inhibited by the strawberry repressor MYB1.
Les migrations internes en France de 1954 à 1975. II. Migrations et urbanisation

Résumé Courgeau Daniel et Lefebvre Monique. — Les migrations internes en France de 1954 à 1975. II. Migrations et urbanisation. Depuis plus d'un siècle, le processus d'urbanisation observé en France, comme dans d'autres pays industrialisés, entraîne la concentration de sa population dans un petit nombre de villes, tandis que les campagnes se dépeuplent. La migration y joue un rôle majeur, tant par ses effectifs que par sa structure par âges, qui entraîne, en dépit d'une faible fécondité urbaine, un accroissement naturel important. Si, avant les années 1970, les échanges entre campagnes et villes de tailles croissantes étaient parfaitement hiérarchisés, cette structure a disparu depuis, conduisant à une répartition plus complexe qui fait intervenir l'âge et les caractéristiques professionnelles. L'analyse détaillée de cette redistribution dans des villes du Sud-Ouest montre que, si, dans le passé, elle pouvait s'opérer à l'intérieur des villes elles-mêmes selon la typologie de l'habitat, elle déborde maintenant, quelle que soit leur taille, sur l'espace rural qui les entoure.
Treatment of pig serum-induced rat liver fibrosis with Boschniakia rossica, oxymatrine and interferon-alpha.

AIM To investigate the effect of Boschniakia rossica (BR), oxymatrine (OM) and interferon-alpha (IFN-alpha) 1b on the therapy of rat liver fibrosis and its mechanism. METHODS By establishing a rat model of pig serum-induced liver fibrosis, liver/weight index and serum alanine transaminase (ALT) were observed to investigate the therapeutic effect of BR,OM and IFN-alpha. Radioimmunoassay was utilized to measure procollagen type III (PCIII) and collagen type IV (CIV). RT-PCR was used to assay the expression of liver transforming growth factor-beta 1 (TGF-beta1) mRNA. Immunohistochemistry of alpha-smooth muscle actin (alpha-SMA) and pathologic changes of liver tissues were also under investigation. RESULTS Serum PCIII and CIV in BR, OM and IFN-alpha groups were significantly declined compared with those in model group, and their RT-PCR revealed that TGF-beta1 mRNA expression was also reduced more than that in model group. Immunohistochemistry demonstrated that alpha-SMA also declined more than that in model group. Serum ALT in IFN-alpha, control and model groups was within normal level. Serum ALT in BR group had no significant difference from those of IFN-alpha, control and model groups. Serum ALT in OM group was significantly higher than those in BR, IFN-alpha, model, and control groups. CONCLUSION BR, OM and IFN-alpha can prevent pig serum-induced liver rat fibrosis by inhibiting the activation of hepatic stellate cells and synthesizing collagen. OM has hepatotoxicity to rat liver fibrosis induced by pig serum.
Knowledge base as a mechanism for perceptual-cognitive tasks: Skill is in the details!

Perceptual-cognitive tasks used for both testing and training in sport will benefit from the inclusion and/or emphasis of knowledge base approaches as a key driving mechanism. In particular, training and testing of decision making skill is discussed. The distinction is made between the isolated decision making approach and the tactics and knowledge base approach to action choices. Knowledge base approaches are seen to provide a more sensitive and mechanistic assessment of skill and underlying response selection processes, and are better able to examine individual differences in the progression from action prediction to action control.