Miracle-dz/UniFAR-FTUs huggingface dataset:
Engineered Nickel Oxide Nanoparticle Causes Substantial Physicochemical Perturbation in Plants

Concentration of engineered nickel oxide nanoparticle (NiO-NP) in nature is on the rise, owing to large scale industrial uses, which have accreted the scope of its exposure to plants, the primary producers of the ecosystem. Though an essential micronutrient for the animal system, supported by numerous studies confirming its toxicity at higher dosages, nickel oxide is graded as a human carcinogen by WHO. A few studies do depict toxicity and bioaccumulation of nickel in plants; however, interaction of NiO-NP with plants is not well-elucidated. It is known that exposure to NiO-NP can incite stress response, leading to cytotoxicity and growth retardation in some plants, but a defined work on the intricate physicochemical cellular responses and genotoxic challenges is wanting. The present study was planned to explore cytotoxicity of NiO-NP in the model plant, Allium cepa L. , its internalization in the tissue and concomitant furore created in the antioxidant enzyme system of the plant. The prospect of the NiO-NP causing genotoxicity was also investigated. Detailed assessments biochemical profiles and genotoxicity potential of NiO-NP on A. cepa L. was performed and extended to four of its closest economically important relatives, Allium sativum L. , Allium schoenoprasum L. , Allium porrum L. , and Allium fistulosum L. Growing root tips were treated with seven different concentrations of NiO-NP suspension (10–500 mg L−1), with deionised distilled water as negative control and 0.4 mM EMS solution as positive control. Study of genotoxic endpoints, like, mitotic indices (MI), chromosomal aberrations (CAs), and chromosome breaks confirmed NiO-NP induced genotoxicity in plants, even at a very low dose (10 mg L−1). That NiO-NP also perturbs biochemical homeostasis, disrupting normal physiology of the cell, was confirmed through changes in state of lipid peroxidation malonaldehyde (MDA), as well as, in oxidation marker enzymes, like catalase (CAT), super oxide dismutase (SOD), and guiacol peroxidase (POD) activities. It was evident that increase in NiO-NP concentration led to decrease in MIs in all the study materials, concomitant with a spike of stress-alleviating, antioxidant enzymes-CAT, POD, SOD, and significant increase in MDA formation. Hence, it can be confirmed that NiO-NP should be treated as an environmental hazard.
Farmer Attitudes toward Proactive Targeting of Agricultural Conservation Programs

Calls for improved targeting of conservation resources are increasingly common. However, arguments for improving the effectiveness and efficiency of agricultural conservation programs through proactive targeting are often tempered by questions regarding political feasibility. Such questions rest on an assumption that there will be resistance to these approaches, whether from farmers, farm groups, or elected officials, yet there is little research-based evidence supporting that assumption. Analysis of data on Iowa farmers’ attitudes toward targeted conservation indicates that most farmers support targeted approaches. Specific factors associated with endorsement of targeted approaches include awareness of agriculture's environmental impacts, belief that farmers should address water quality problems, having experienced significant soil erosion, belief that extreme weather will become more common, participation in the Conservation Reserve Program, and belief that farmers who have natural resource issues are less likely to seek conservation assistance. Concerns about government intrusion were negative predictors of support for targeted approaches.
Chinese multinational firms in Asia and Africa: Relationships with institutional actors and patterns of HRM practices

Interest in the internationalization of Chinese firms has soared in recent years. However, studies that compare Chinese multinational corporations (MNCs) in different industries and their human resource management (HRM) remain limited. This study fills this research gap by examining the HRM practices of Chinese MNCs and the extent to which these are shaped by the institutional factors that are specific to industries. It focuses on the Chinese operations in the South/Southeast Asian and African regions because Chinese firms tend to have various competitive advantages in these regions. The article draws on a number of theoretical perspectives, particularly the political economy and institutional perspectives, to make sense of the different contexts under which Chinese MNCs invest and operate. It argues that in examining Chinese MNCs, it is important to contemplate the role of the government and a wider range of institutional actors in order to understand how the dynamic interactions of these actors may shape the HRM of these firms with broader economic and social impacts
Risk associated with managed investment primary production projects

The paper presents a model of investment risk associated with projects that promote primary production, such as plantations, forests, aquaculture and agribusiness generally, commonly through managed investment schemes (MISs) set up as businesses. An analysis of business failures leads to a finite probability that the investor will lose money. The attractiveness of the investment is further diminished because of the uncertainty in the downstream return on investment and time of the return. Based on probabilistic arguments, the paper presents a robust model and method on which to make investment decisions. The approach is practical and will be useful to people interested in managed agribusiness investments. The approach is significant in that it quantifies what heretofore was largely undertaken qualitatively.
Azithromycin versus Ciprofloxacin for Treatment of Uncomplicated Typhoid Fever in a Randomized Trial in Egypt That Included Patients with Multidrug Resistance

ABSTRACT To compare clinical and bacteriological efficacies of azithromycin and ciprofloxacin for typhoid fever, 123 adults with fever and signs of uncomplicated typhoid fever were entered into a randomized trial. Cultures of blood were positive for Salmonella typhi in 59 patients and for S. paratyphi A in 3 cases; stool cultures were positive for S. typhi in 11 cases and for S. paratyphi A in 1 case. Multiple-drug resistance (MDR; resistance to ampicillin, chloramphenicol, and trimethoprim-sulfamethoxazole) was present in isolates of 21 of 64 patients with positive cultures. Of these 64 patients, 36 received 1 g of azithromycin orally once on the first day, followed by 500 mg given orally once daily on the next 6 days; 28 patients received 500 mg of ciprofloxacin orally twice daily for 7 days. Blood cultures were repeated on days 4 and 10 after the start of therapy, and stool cultures were done on days 4, 10, and 28 after the start of therapy. All patients in both groups improved during therapy and were cured. Defervescence (maximum daily temperatures of ≤38°C) occurred at the following times [mean ± standard deviation (range)] after the start of therapy: 3.8 ± 1.1 (2 to 7) days with azithromycin and 3.3 ± 1.0 (1 to 5) days with ciprofloxacin. No relapses were detected. Cultures of blood and stool during and after therapy were negative in all cases, except for one patient treated with azithromycin who had a positive blood culture on day 4. These results indicated that azithromycin and ciprofloxacin were similarly effective, both clinically and bacteriologically, against typhoid fever caused by both sensitive organisms and MDRS. typhi.
Japan in 2008: A Prelude to Change??

Events in 2008 suggest that the Koizumi era is over and the Liberal Democratic Party will lose the lower house election that must be called before its current term expires in September 2009. The Democratic Party of Japan became the favorite to win the election and laid out the new domestic and foreign policy directions in which it will take Japan.
Ersatz Academics and Scholar-saints: The Supply of Financial Accounting Research

Watts and Zimmerman, in a widely acclaimed article, concluded that accounting theories serve to supply excuses for policies determined by political processes. This paper presents a critical review of Watts and Zimmerman's hypothesis, and in return, suggests that the academic reward system in the leading universities does not encourage that kind of activity. The alternative hypothesis is that there are two markets, one for excuses and the other for scholarly research.
Cloning and Expression of Mouse Liver Phosphatidylserine Synthase-1 cDNA

In eukaryotic cells, phosphatidylserine (PtdSer) is synthesized by two distinct synthases on the endoplasmic reticulum by a base-exchange reaction in which the polar head-group of an existing phospholipid is replaced with serine. We report the cloning and expression of a cDNA for mouse liver PtdSer synthase-1. The deduced protein sequence is >90% identical to that of PtdSer synthase-1 from Chinese hamster ovary cells and a sequence from a human myeloblast cell line. PtdSer synthase-1 cDNA was stably expressed in M.9. 1.1 cells which are mutant Chinese hamster ovary cells defective in PtdSer synthase-1 activity, are ethanolamine auxotrophs, and have a reduced content of PtdSer and phosphatidylethanolamine (PtdEtn). The growth defect of M.9. 1.1 cells was eliminated, and a normal phospholipid composition was restored in the absence of exogenous ethanolamine, implying that the cloned cDNA encoded PtdSer synthase. Mouse liver PtdSer synthase-1 was also expressed in McArdle 7777 rat hepatoma cells. In addition to a 3-fold higher in vitro serine-exchange activity, these cells also exhibited enhanced choline- and ethanolamine-exchange activities and incorporated more [3H]serine into PtdSer than did control cells. However, the levels of PtdSer and PtdEtn in cells overexpressing PtdSer synthase-1 activity were not increased. Excess PtdSer produced by the transfected cells was rapidly decarboxylated to PtdEtn and the degradation of PtdSer, and/or PtdEtn derived from PtdSer, was increased. Moreover, the CDP-ethanolamine pathway for PtdEtn biosynthesis was inhibited. These data suggest that (i) cellular levels of PtdSer and PtdEtn are tightly controlled, and (ii) the metabolism of PtdSer and PtdEtn is coordinately regulated to maintain phospholipid homeostasis.
Prevalence of Blood-Borne Infectious Diseases in Blood Donors in Ghana

ABSTRACT Transfusion-transmissible infections among 808 blood donors in Ghana were investigated in 1999. Antibody seroprevalences of 3.8, 0.7, 8.4, and 13.5%, respectively, for human immunodeficiency virus, human T-cell lymphotrophic virus type 1, hepatitis C virus (HCV), and Treponema pallidum were obtained. The seroprevalence of HCV infection was confirmed to be 0.9% after supplementary testing, and the transfusion risk potential of these pathogens was demonstrated.
Developing Enabling Performance Measurement Systems: On the Interplay Between Numbers and Operational Knowledge

Abstract Performance measurement systems (PMSs) are generally regarded to serve the needs of top managers. However, a growing literature has started to explore what it takes for these systems to be(come) enabling also for those whose performance is being measured. In this paper, we build on and add to this literature by providing ethnographic insights into how and why a group of middle-managers transformed a set of performance measures, initially developed as monitoring devices for top management, into a so-called enabling PMS. Regarding how this came about, we elaborate on how actors mobilised two different forms of mental models of the operations (specific and generalised), and a set of number-to-number tactics, as important means in their development work. Regarding the why-question, we identify a high evaluation pressure from top management, in combination with recurrent reconstructions of the existing mental models of operations, as important conditions that worked to initiate, fuel, and, eventually, cease the process.
Calendar Anomalies: Abnormal Returns at Calendar Turning Points

There is overwhelming evidence that abnormal equity returns are associated with the turn of the year, the week and the month, as well as with holidays and the time of day. These returns are not unique to one historical period, nor can they be explained by considerations of risk or value. Tax-loss selling at year-end, cash flows at month-end and negative news releases over the weekend may explain some of these return abnormalities. But human psychology offers a more promising explanation. Calendar anomalies tend to occur at turning points in time. While these artificial moments have little economic significance, investors may deem them important, and behave accordingly. The question remains why these effects, which have been recognized for some years, have not been arbitraged away. Trading costs are, of course, an impediment. A portfolio manager would not consider liquidating an entire portfolio on a Friday merely in order to avoid experiencing relatively poor weekend returns. But planned trades can be scheduled to take advantage of calendar-based return patterns. Calendar effects should be of particular importance to traders.
Decision orders: a decision taxonomy

Purpose – The proper identification of a decision problem is paramount to finding a course of action or solution. This paper attempts to capture the general laws or principles that define decision problems. These principles are then used to establish a decision classification system called the decision‐order taxonomy.Design/methodology/approach – The decision‐order taxonomy is developed by performing a content analysis on the seminal literature in the natural, social, and applied sciences. By identifying the semantic descriptors used to partition various domains, an implicit taxonomy for proper identification of decision problems is hypothesized.Findings – The multidimensional taxonomic classification system and defined nomenclature, together with the identification process, comprise the complete decision‐order taxonomy developed in this paper. While applying the decision‐order taxonomy to an actual decision problem, insights are exposed which will guide the decision maker toward appropriate solution meth.
Home Bias in Currency Forecasts

The "home bias" phenomenon states that empirically, economic agents often under-utilize opportunities beyond their country borders, and it is well-documented in various international pricing and purchase patterns. This bias manifests in the forms of fewer exchanges of goods and net equity-holdings, as well as less arbitrage of price differences across borders than theoretically predicted to be optimal. Our paper documents another form of home bias, where market participants appear to under-weigh information beyond their borders when making currency forecasts. Using monthly data from 1995 to 2010 for seven major exchange rates relative to the US dollar, we show that excess currency returns and the errors in investors' consensus forecasts not only depend on the interest differentials between the pair of countries, but they depend more strongly on interest rates in a broader set of countries. A global short interest differential and a global long interest differential are driving the results.
Origin, Impact and Cost of Interface Instability

Third-party libraries are used frequently in modern software development. Websites that are visited millions of times a day often make heavy use of open-source software libraries. As a software developer, using these libraries has a number of advantages. Developers save time and effort because functionality does not have to be rebuilt from scratch. Additionally, these libraries are often completely free to use, have been tested extensively by other users and contain a large amount of expertise of other developers. There are also a number of disadvantages to using these libraries. When the interface of a software library changes, this has direct impact on software systems using this interface. In this thesis, the origin, impact and costs of interface instability is investigated. As it turns out, public interfaces of software libraries frequently change without providing proper signals to users of that interface. These changes have measurable impact in systems using these interfaces. Besides changes in interfaces, changes in functionality can also impact end users of a library. In this thesis, compression is employed to measure changes in functionality that a library provides. These changes in functionality are then used in a software growth model that relates the concepts of software growth, quality, work done and size to each other.
An Improved Abstract GPU Model with Data Transfer

GPUs are commonly used as coprocessors to accelerate a compute-intensive task, thanks to their massively parallel architecture. There is study into different abstract parallel models, which allow researchers to design and analyse parallel algorithms. However, most work on analysing GPU algorithms has been software based tools for profiling a GPU algorithm. Recently, some abstract GPU models have been proposed, yet they do not capture all elements of a GPU. In particular, they miss the data transfer between CPU and GPU, which in practice can cause a bottleneck and reduce performance dramatically. We propose a comprehensive model called Abstract Transferring GPU which to our knowledge is the first abstract GPU model to capture data transfer between CPU and GPU. We show via experiments, that existing abstract GPU models cannot sufficiently capture all of the actual running of a GPU algorithm time in all cases, as they do not capture data transfer. We show that by capturing data transfer with our model, we are able to obtain more accurate predictions of the GPU algorithm actual running time. It is expected that our model helps improve design and analysis of heterogeneous systems consisting of CPU and GPU, and will allow researchers to make better informed implementation decisions, as they will be aware how data transfer will affect their programs.
JOINTLY‐DETERMINED ECOLOGICAL THRESHOLDS AND ECONOMIC TRADE‐OFFS IN WILDLIFE DISEASE MANAGEMENT

ABSTRACT. We investigate wildlife disease management, in a bioeconomic framework, when the wildlife host is valuable and disease transmission is density‐dependent. Disease prevalence is reduced in density‐dependent models whenever the population is harvested below a host‐density threshold a threshold population density below which disease prevalence declines and above which a disease becomes epidemic. In conventional models, the threshold is an exogenous function of disease parameters. We consider this case and find a steady state with positive disease prevalence to be optimal. Next, we consider a case in which disease dynamics are affected by both population controls and changes in human‐environmental interactions. The host‐density threshold is endogenous in this case. That is, the manager does not simply manage the population relative to the threshold, but rather manages both the population and the threshold. The optimal threshold depends on the economic and ecological trade‐offs arising from the jointly‐determined system. Accounting for this endogene‐ity can lead to reduced disease prevalence rates and higher population levels. Additionally, we show that ecological parameters that may be unimportant in conventional models that do not account for the endogeneity of the host‐density threshold are potentially important when host density threshold is recognized as endogenous.
Evidence for a similar or common mechanism for natural killer cell activity and resistance to hemopoietic grafts

Two types of host reactivities not requiring immunization in the mouse and not mediated by T lymphocytes were compared: resistance of irradiated and nonirradiated F1 hybrids to accept parental grafts of normal or malignant hemopoietic cells (Hh system), and the natural killer cell activity against mouse lymphomas (NK system). The effects of six independent variables known to influence resistance to marrow grafts were investigated in the NK system using YAC‐1 lymphoma cells as targets. The following properties were shared: (a) maturation during the fourth week of life; (b) low sensitivity to acute total body irradiation; (c) dependence on the integrity of bone marrow as demonstrated by reduced reactivity in 89Sr‐treated mice; (d) suppression by a single injection of rabbit anti‐mouse bone marrow serum; (e) suppression by a single injection of the anti‐macrophage agents silica and i‐carrageenan; and (f) suppression by multiple injections of parental spleen cells into F1 mice. These positive correlations are particularly significant because most of the variables have either opposing or no effect on conventional immunity. F1 mice rendered specifically unresponsive to parental marrow grafts, could retain NK cell activity, and genetically susceptible mice could be rendered hyporeactive in terms of NK cells, indicating that the specificities of YAC‐1 and Hh‐1 incompatible targets were different.
Utilization of MEMS Tunable Inductors in the design of RF voltage-controlled oscillators

This paper presents the concept of using a MEMS piezoelectric actuated tunable inductor in the design of a wideband high performance VCO. Furthermore, a model of the tunable inductor is presented to facilitate the VCO design and simulation. In addition, by means of this model important characteristics of the tunable inductor can be derived enabling a design of the VCO to be superior in phase noise and power consumption to one which makes use of conventional capacitive tuning as indicated by the simulation results.
Evaluation of the activated charcoals and adsorption conditions used in the treatment of sugarcane bagasse hydrolysate for xylitol production

Xylitol has sweetening, anticariogenic and clinical properties that have attracted the attention of the food and pharmaceutical industries. The conversion of sugars from lignocellulosic biomass into xylitol by D-xylose-fermenting yeast represents an alternative to the chemical process for producing this polyol. A good source of D-xylose is sugarcane bagasse, which can be hydrolyzed with dilute acid. However, acetic acid, which is toxic to the yeast, also appears in the hydrolysate, inhibiting microbe metabolism. Xylitol production depends on the initial D-xylose concentration, which can be increased by concentrating the hydrolysate by vacuum evaporation. However, with this procedure the amount of acetic acid is also increased, aggravating the problem of cell inhibition. Hydrolysate treatment with powdered activated charcoal is used to remove or decrease the concentration of this inhibitor, improving xylitol productivity as a consequence. Our work was an attempt to improve the fermentation of Candida guilliermondii yeast in sugarcane bagasse hydrolysate by treating the medium with seven types of commercial powdered activated charcoals (Synth, Carbon Delta A, Carbon Delta G, Carbon 117, Carbon 118L, Carbon 147 and Carvorite), each with its own unique physicochemical properties. Various adsorption conditions were established for the variables temperature, contact time, shaking, pH and charcoal concentration. The experiments were based on multivariate statistical concepts, with the application of fractional factorial design techniques to identify the variables that are important in the process. Subsequently, the levels of these variables were quantified by overlaying the level curves, which permitted the establishment of the best adsorption conditions for attaining high levels of xylitol volumetric productivity and D-xylose-to-xylitol conversion. This procedure consisted in increasing the original pH of the hydrolysate to 7.0 with CaO and reducing it to 5.5 with H3PO4. Next, the hydrolysate was treated under adsorption conditions employing CDA powdered activated charcoal (1%) for 30 min at 60oC, 100 rpm and pH 2.5. The optimized xylitol volumetric productivity (0.50 g/L h) corresponded to a D-xylose-to-xylitol conversion of 0.66 g/g.