Miracle-dz/UniFAR-FTUs huggingface dataset:
Searching for threat

In a series of experiments, a visual search task was used to test the idea that biologically relevant threatening stimuli might be recognized very quickly or capture visuo-spatial attention. In Experiment 1, there was evidence for both faster detection and faster search rates for threatening animals than for plants. However, examination of the basis of this effect in Experiment 2 showed that it was not due to threat per se, as detection and search rate advantages were found for pleasant rather than threatening animals compared to plants. In Experiment 3, participants searched for the plants and pleasant and threatening animals used in Experiments 1 and 2, among a fixed heterogeneous selection of non-target items. There was no search rate or detection advantage for threatening animals compared to pleasant animals or plants. The same targets and non-targets as those used in Experiment 3 were also used in Experiment 4. In Experiment 4, participants searched for targets that were presented either close to or distant from an initial fixation point. There was no evidence for a “threat” detection advantage either close to or distant from the cross. Finally, an experiment was conducted in which target categories (fruit, flowers, and animals) were not pre-specified prior to each trial block. There were no differences in reaction times to detect pleasant animals, threatening animals, or fruit. We conclude that the visual search paradigm does not readily reveal any biases that might exist for threatening stimuli in the general population.
Information to cerebellum on spinal motor networks mediated by the dorsal spinocerebellar tract

Abstract The main objective of this review is to re‐examine the type of information transmitted by the dorsal and ventral spinocerebellar tracts (DSCT and VSCT respectively) during rhythmic motor actions such as locomotion. Based on experiments in the 1960s and 1970s, the DSCT was viewed as a relay of peripheral sensory input to the cerebellum in general, and during rhythmic movements such as locomotion and scratch. In contrast, the VSCT was seen as conveying a copy of the output of spinal neuronal circuitry, including those circuits generating rhythmic motor activity (the spinal central pattern generator, CPG). Emerging anatomical and electrophysiological information on the putative subpopulations of DSCT and VSCT neurons suggest differentiated functions for some of the subpopulations. Multiple lines of evidence support the notion that sensory input is not the only source driving DSCT neurons and, overall, there is a greater similarity between DSCT and VSCT activity than previously acknowledged. Indeed the majority of DSCT cells can be driven by spinal CPGs for locomotion and scratch without phasic sensory input. It thus seems natural to propose the possibility that CPG input to some of these neurons may contribute to distinguishing sensory inputs that are a consequence of the active locomotion from those resulting from perturbations in the external world.
Identification of gp120 Regions Targeted by a Highly Potent Neutralizing Antiserum Elicited in a Chimpanzee Inoculated with a Primary Human Immunodeficiency Virus Type 1 Isolate

ABSTRACT We have previously reported that a chimpanzee infected with a primary human immunodeficiency virus type 1 (HIV-1) isolate (HIV-1DH12) developed an extremely potent virus-neutralizing antibody. Immunoglobulin G purified from this animal conferred sterilizing immunity following passive transfer to macaques which were subsequently challenged with simian immunodeficiency virus/HIV-1 chimeric virus strain DH12. In addition to being highly strain specific, the chimpanzee antiserum did not bind to the V3 loop peptide of HIV-1DH12, nor did it block the interaction of gp120 with the CD4 receptor. When neutralization was examined in the context of virus particles carrying chimeric envelope glycoproteins, the presence of all five hypervariable regions (V1 to V5) was required for optimal neutralization. Virions bearing chimeric gp120 containing the V1–V2 and V4 regions of HIV-1DH12 could also be neutralized, but larger quantities of the chimpanzee antiserum were needed to block infection. These results indicate that the HIV-1 gp120 epitope(s) targeted by the chimpanzee antiserum is highly conformational, involving surface elements contributed by all of the hypervariable domains of the envelope glycoprotein.
Competitive Productivism and Australia's Emerging ‘Alternative’ Agri-food Networks: producing for farmers' markets in Victoria and beyond

Abstract This paper advances the theoretical argument for moving beyond the conventional/alternative divide in the analysis of emerging ‘alternative’ agri-food networks (AAFNs). In order to understand how ‘place’, ‘nature’ and ‘quality’-based food networks emerge and develop, we argue that careful attention needs to be paid to the way in which specific political-economic environments shape the options available to farmers and consumers. Australia's ‘competitive productivism’ is the outcome of an export-oriented economy and a neoliberal political orientation, and this environment affects the development of AAFNs in various ways. Most notably, a case study of farmers that sell at farmers' markets in the State of Victoria shows that the competitive-productivist policies pursued by Australian governments entice some farmers who participate in AAFNs to develop their ideas into higher output businesses tailored to compete in emerging export markets. Other farmers deliberately choose to keep marketing through alternative channels despite competitive-productivist pressures to expand. These findings demonstrate the centrality to the experience of AAFN participants of negotiating productivist pressures, adding nuances to the story of the complex relations between AAFNs and conventional supply chains.
Price Adjustment and Exchange Rate Pass-Through

This paper develops a simple theoretical model that can be used to account for the determinants of exchange rate pass-through to consumer prices. While recent evidence has found low estimates of pass-through in many countries, there is little consensus on an explanation for this. Our paper argues that sticky prices represent a key determinant of exchange rate pass-through. We make this argument in two stages. First, holding the frequency of price change constant, we show that our model calibrated to data from low-inflation countries can reproduce the estimates of very low pass-through for these countries. The principal determinant of low pass-through in this case is the slow adjustment of prices. We then extend the model to allow the frequency of price change to be endogenous. Calibrating to a wider set of countries, including both low-inflation and high-inflation countries, we show that our model implies that exchange rate pass-through is increasing in average inflation, but at a declining rate. Performing the identical exercise on the data, we find a striking correspondence between the predictions of the model and those of the data.
GAAFET Versus Pragmatic FinFET at the 5nm Si-Based CMOS Technology Node

Speed and power performances of Si-based stacked-nanowire gate-all-around (GAA) FETs and pragmatic ultra-thin-fin FETs at the 5nm CMOS technology node are projected, compared, and physically explained based on 3-D numerical simulations. The respective device domains are also used to compare integration densities based on 6T-SRAM layouts. Predicted comparable performances and densities, with considerations of the complexity/cost of GAAFET processing versus that of the FinFET with pragmatic simplifications, suggest that the FinFET is the better choice for the future.
Change in the air

With the higher levels of wind power and other renewable generation now included in the North American electrical system, operational information plays an increasing role in the decisions that grid operators are asked to make on a daily basis. While wind forecasting was something that was considered a luxury only a few years ago, it is critical to today's operation. There are other solutions that the industry is developing to incorporate high levels of wind, such as demand-side management, developing flexible resources to accommodate ramping and cycling needs, and developing larger BAs and market tools to allow the development of ancillary services. But wind forecasting will always be a crucial part of the solution and the primary tool that grid operators will rely on to implement policies and procedures to reliably and economically operate the system.
Oral health behaviour of children and adults in urban and rural areas of Burkina Faso, Africa.

OBJECTIVES To assess the level of dental knowledge and attitudes among 12 year-old children and 35-44 year-olds in Burkina Faso; to evaluate the pattern of oral health behaviour among these cohorts in relation to location, gender and social characteristics and; to evaluate the relative effect of social-behavioural risk factors on caries experience. DESIGN Across sectional study including urban and rural subgroups of population. SAMPLE AND METHODS Multistage cluster sampling of households in urban areas; in rural areas random samples of participants were based on the recent population census. The final study population covered two age groups: 12 years (n = 505) and 35-44 years (n = 493). RESULTS For both children and adults, levels of oral health knowledge, attitudes and self-care were low; 36% of 12-year-olds and 57% of 35-44-year-olds carried out toothcleaning on a daily basis. Pain and discomfort from teeth were common while dental visits were infrequent. Tooth cleaning was mostly performed by use of chewsticks. Use of toothpaste was rare, particularly fluoridated toothpaste was seldom; 9% of 12-year-olds and 18% of 35-44-year-olds reported use of fluoride toothpaste. Significant differences were found in oral health knowledge, attitudes and practices according to location and gender. At age 12, important factors of high caries experience were location (urban), and consumption of soft drinks and fresh fruits. In 35-44-year-olds, gender (female), high education level, dental visit and occupation (government employee) were the significant factors of high dental caries experience whereas adults using traditional chewing sticks had lower DMFT. CONCLUSIONS Health authorities should strengthen the implementation of oral disease prevention and health promotion programmes rather than traditional curative care. Community-oriented essential care and affordable fluoride toothpaste should be encouraged.
A Model for QoS – Aware Wireless Communication in Hospitals

In the recent decade, research regarding wireless applications in electronic health (e-Health) services has been increasing. The main benefits of using wireless technologies in e-Health applications are simple communications, fast delivery of medical information, reducing treatment cost and also reducing the medical workers’ error rate. However, using wireless communications in sensitive healthcare environment raises electromagnetic interference (EMI). One of the most effective methods to avoid the EMI problem is power management. To this end, some of methods have been proposed in the literature to reduce EMI effects in health care environments. However, using these methods may result in nonaccurate interference avoidance and also may increase network complexity. To overcome these problems, we introduce two approaches based on per-user location and hospital sectoring for power management in sensitive healthcare environments. Although reducing transmission power could avoid EMI, it causes a number of successful message deliveries to the access point to decrease and, hence, the quality of service requirements cannot be meet. In this paper, we propose the use of relays for decreasing the probability of outage in the aforementioned scenario. Relay placement is the main factor to enjoy the usefulness of relay station benefits in the network and, therefore, we use the genetic algorithm to compute the optimum positions of a fixed number of relays. We have considered delay and maximum blind point coverage as two main criteria in relay station problem. The performance of the proposed method in outage reduction is investigated through simulations.
The Influence of Time Management Practices on Job Stress Level among Beginning Secondary Agriculture Teachers.

Monitoring the stress of teachers continues to be important – particularly stress levels of beginning agriculture teachers. The study sought to describe the relationship between beginning teachers’ perceived ability to manage their time and their level of stress. The Time Management Practices Inventory and the Job Stress Survey were used to measure and collect the data. The study was comprised of 36 beginning secondary agriculture teachers in Missouri. A highlight of the findings suggests that beginning teachers tend to perceive themselves as good managers of time when compared to norm data. Additionally, on average, these teachers are not in a state of stress. Low to negligible relationships exist between the seven time management practices and teachers’ scores on the job stress, job pressure, and lack of support indices.
Adolescent Fertility in Low- and Middle-Income Countries: Effects and Solutions

Adolescent fertility in low- and middle-income countries presents a severe impediment to development and can lead to school dropout, lost productivity, and the intergenerational transmission of poverty. However, there is debate about whether adolescent pregnancy is a problem in and of itself or merely symptomatic of deeper, ingrained disadvantage. To inform policy choices and create a revised research agenda for population and development, this paper aggregates recent quantitative evidence on the socioeconomic consequences of and methods to reduce of teenage pregnancy in the developing world. The review finds variable results for all indicator types with the partial exception of knowledge-based indicators, which increased in response to almost all evaluating interventions, though it is not clear that such interventions necessarily lead to short- or long term-behavior change. [CGD Working paper no. 295]. URL:[http://www.cgdev. org/files/1426175_file_McQueston_Silverman_Glassman_AdolescentFertility_FINAL. pdf].
Dorfin prevents cell death by reducing mitochondrial localizing mutant superoxide dismutase 1 in a neuronal cell model of familial amyotrophic lateral sclerosis

Dorfin is a RING‐finger type ubiquitin ligase for mutant superoxide dismutase 1 (SOD1) that enhances its degradation. Mutant SOD1s cause familial amyotrophic lateral sclerosis (FALS) through the gain of unelucidated toxic properties. We previously showed that the accumulation of mutant SOD1 in the mitochondria triggered the release of cytochrome c, followed by the activation of the caspase cascade and induction of neuronal cell death. In the present study, therefore, we investigated whether Dorfin can modulate the level of mutant SOD1 in the mitochondria and subsequent caspase activation. We showed that Dorfin significantly reduced the amount of mutant SOD1 in the mitochondria, the release of cytochrome c and the activation of the following caspase cascade, thereby preventing eventual neuronal cell death in a neuronal cell model of FALS. These results suggest that reducing the accumulation of mutant SOD1 in the mitochondria may be a new therapeutic strategy for mutant SOD1‐associated FALS, and that Dorfin may play a significant role in this.
Protein kinase substrate recognition studied using the recombinant catalytic domain of AMP-activated protein kinase and a model substrate.

We have expressed a truncated form of the alpha1 kinase domain of AMP-activated protein kinase (AMPK) in Escherichia coli as a glutathione-S-transferase fusion (GST-KD). A T172D mutant version did not require prior phosphorylation and was utilized for most subsequent studies. We have also created a recombinant substrate (GST-ACC) by expressing 34 residues around the major phosphorylation site (Ser79) on rat acetyl-CoA carboxylase-1/alpha (ACC1) as a GST fusion. This was an excellent substrate that was phosphorylated with similar kinetic parameters to ACC1 by both native AMPK and the bacterially expressed kinase domain. We also constructed a structural model for the binding of the ACC1 sequence to the kinase domain, based on crystal structures for related protein kinases. The model was tested by making a total of 25 mutants of GST-ACC and seven mutants of GST-KD, and measuring kinetic parameters with different combinations. The results reveal that AMPK and ACC1 interact over a much wider region than previously realized (>20 residues). The features of the interaction can be summarised as follows: (i) an amphipathic helix from P-16 to P-5 on the substrate binds in a hydrophobic groove on the large lobe of the kinase; (ii) basic residues at P-6 and P-4 bind to two acidic patches (D215/D216/D217 and E103/D100/E143, respectively), on the large lobe; (iii) a histidine at P+3 interacts with D56 on the small lobe; (iv) the side-chain of P+4 leucine could not be precisely positioned, but a new finding was that asparagine or glutamine could replace a hydrophobic residue at this position. These interactions position the serine residue to be phosphorylated in close proximity to the gamma-phosphate group of ATP. Although based on modelling rather than a determined structure, this represents one of the most detailed studies of the interaction between a kinase and its substrate achieved to date.
Genetic analysis of human immunodeficiency virus type 1 envelope V3 region isolates from mothers and infants after perinatal transmission

The human immunodeficiency virus type 1 (HIV-1) sequences from variable region 3 (V3) of the envelope gene were analyzed from seven infected mother-infant pairs following perinatal transmission. The V3 region sequences directly derived from the DNA of the uncultured peripheral blood mononuclear cells from infected mothers displayed a heterogeneous population. In contrast, the infants' sequences were less diverse than those of their mothers. In addition, the sequences from the younger infants' peripheral blood mononuclear cell DNA were more homogeneous than the older infants' sequences. All infants' sequences were different but displayed patterns similar to those seen in their mothers. In the mother-infant pair sequences analyzed, a minor genotype or subtype found in the mothers predominated in their infants. The conserved N-linked glycosylation site proximal to the first cysteine of the V3 loop was absent only in one infant's sequence set and in some variants of two other infants' sequences. Furthermore, the HIV-1 sequences of the epidemiologically linked mother-infant pairs were closer than the sequences of epidemiologically unlinked individuals, suggesting that the sequence comparison of mother-infant pairs done in order to identify genetic variants transmitted from mother to infant could be performed even in older infants. There was no evidence for transmission of a major genotype or multiple genotypes from mother to infant. In conclusion, a minor genotype of maternal virus is transmitted to the infants, and this finding could be useful in developing strategies to prevent maternal transmission of HIV-1 by means of perinatal interventions.
Designing a novel Peer-to-Peer network

Peer-to-Peer (P2P) networks are widely used in today's Internet. Researchers claim that churn could bring down the performance in p2p networks. AS churn is an inherent character. Researchers want to find some ways to keep down. We investigate this in another point of view, from the searching aspect, churn can bring up search efficiency for repeated search. In this paper, we build a novel peer to peer network in which edges re-connecte actively. Then we introduce how a resource disseminated in it during the time runs off. The last point is that we explain what dose this design gain for searching a resource.
Causality and a firm-level innovation scoreboard

In this article, we construct an innovation scoreboard based on a conceptually acceptable endogenous indicator which is shown to be the output caused by the innovation generating process. A balanced panel of data on 552 UK firms over the period 1994–2005 is used to test for causality using general methods of moments (GMM) estimation and other techniques. With innovation defined as the successful exploitation of new ideas, it is proposed that exploitation be measured by total factor productivity; success be measured by the return on capital employed and their multiple be taken as the indicator of innovation. Results for the sample firms are presented and discussed.
Inflation Inequality in Europe

We analyze cross-household inflation dispersion in Europe using “fictitious” monthly inflation rates for several household categories (grouped according to income levels, household size, socio-economic status, age) for the period from 1997 to 2008. Our analysis is carried out on a panel of 23 up to 27 household-specific inflation rates per country for 15 countries. In the first part of the paper, we employ time series and related non-stationary panel approaches to shed light on cross-country differences in inflation inequality with respect to the number of driving forces in the panel. In particular, we focus on the degree of persistence of the household-specific inflation rates and their the adjustment behaviour towards the inflation rate of a “representative household”. In the second part of the paper, we pool over the full sample of all countries and test if and by how much certain household categories across Europe are more prone to significant inflation differentials and significant differences in the volatility of inflation. Furthermore we search for the presence of clusters with respect to inflation susceptibility. On the national level, we find evidence for the existence of one main driving factor driving the non-stationarity of the panel and evidence for a single co-integration vector. Persistence of deviations, however, is high, and the adjustment speed towards the “representative household” is low. Even if there is no concern about a long-run stable distribution, at least in the short- to medium run deviations tend to last. On the European level, we find small but significant differences (mainly along income levels), we can separate 5 clusters and two main driving forces for the differences in the overall panel. All in all, even if differences are relatively small, they are not negligible and persistent enough to represent a serious matter of debate for economic and social policy.
A heuristic method for design of survivable WDM networks with p-cycles

We consider a new heuristic method for design of survivable wavelength-division multiplexing (WDM) networks with preconfigured protection cycles (p-cycles). Numerical studies show that the new heuristic works well for different traffic patterns, and the spare capacity obtained by the new heuristic is very close to that of the optimal solution but with much reduced computational time.
Performance preserving controller reduction via additive perturbation of the closed-loop transfer function

An H/sub /spl infin// performance preserving controller order reduction method is proposed. Here performance preservation indicates that the H/sub /spl infin// norm bound of the closed loop transfer function with reduced-order controller is not greater than the H/sub /spl infin// norm bound of the closed loop transfer function with full order controller. We assume additive perturbations to the closed-loop transfer function and obtain a sufficient condition for performance preservation. Two kinds of useful weightings are derived, and the controller reduction problem is solved via a frequency weighted model reduction problem.