Miracle-dz/UniFAR-FTUs huggingface dataset:
Uraz seksualny jako czynnik ryzyka zaburzeń doświadczania własnej cielesności Sexual trauma as a risk factor of disorders in experiencing of one's own body

Introduction. The aim of this work is to examine the relation between sexual trauma experience and experiencing of one’s body. Material and methods. Material and methods. Material and methods. Material and methods. Material and methods. The study involved the Questionnaire of Body Self of Sakson-Obada and a standardized set of questions relevant to particular characteristics of sexual violence. Measurement were administered among control and clinical groups. The control group consisted of 149 women who have not experienced sexual violence and in clinical group there were 43 women who experienced sexual trauma. Results. The study showed that women who experienced sexual violence, compared to women without such experiences have weaker body self. Also the relationship between experiencing of one’s body and particular characteristics of sexual trauma was found The presence of such characteristics of trauma as sexual coercion, the repetition of trauma and close relationship with the perpetrator are connected with the most problems in body self. Conclusion. The obtained results indicate that sexual trauma is a significant risk factor in disorders in experiencing of one’s own body. Aspects of body self, which seem to be especially susceptible to disturbance as
Cell Cycle and Transcriptional Control of Human Myeloid Leukemic Cells by Transforming Growth Factor Beta

TGFβ1 is a potent growth inhibitor of both primitive and more differentiated human myeloid leukemic cells. The extent of the growth inhibitory response to TGFP varies with cell type, and is not linked to stages of differentiation of cell lines. Downregulation of multiple cell cycle-regulatory molecules is a dominant event in TGFβ1-mediated growth inhibition of human MV4-11 myeloid leukemia cells. Both G1-phase and G2-phase cyclins and cdks participate in the regulation of TGFβ1-mediated growth inhibition of MV4-11 cells. By both depressing cdk2 synthesis and up-regulating cyclin E-associated p27, TGFβ1 may magnify its inhibitory efficiency. TGFβ1 also rapidly inhibits phosphorylation of pRb at several serine and threonine residues. The underphosphorylated pRb associates with E2F-4 in G1 phase, whereas the phosphorylated pRb mainly binds to E2F-1 and E2F-3 in proliferating MV4-11 cells. Since TGFpi upregulates p130/E2F-4 complex formation and downregulates p107/E2F-4 complex formation, with E2F-4 levels remaining constant, our results suggest that E2F-4 is switched from pl07 to pRb and p130 when cells exit from the cell cycle and arrest in G1 by TGFpi. In summary, TGFpi inhibits growth of human myeloid leukemic cells through multiple pathways, whereas the “cdk inhibitor” p27 is both a positive and negative regulator.
Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells

During skeletal muscle development, nuclei move dynamically through myotubes in a microtubule-dependent manner, driven by the microtubule motor protein kinesin-1. Loss of kinesin-1 leads to improperly positioned nuclei in culture and in vivo. Two models have been proposed to explain how kinesin-1 functions to move nuclei in myotubes. In the cargo model, kinesin-1 acts directly from the surface of the nucleus, whereas in an alternative model, kinesin-1 moves nuclei indirectly by sliding anti-parallel microtubules. Here, we test the hypothesis that an ensemble of Kif5B motors acts from the nuclear envelope to distribute nuclei throughout the length of syncytial myotubes. First, using an inducible dimerization system, we show that controlled recruitment of truncated, constitutively active kinesin-1 motors to the nuclear envelope is sufficient to prevent the nuclear aggregation resulting from depletion of endogenous kinesin-1. Second, we identify a conserved kinesin light chain (KLC)-binding motif in the nuclear envelope proteins nesprin-1 and nesprin-2, and show that recruitment of the motor complex to the nucleus via this LEWD motif is essential for nuclear distribution. Together, our findings demonstrate that the nucleus is a kinesin-1 cargo in myotubes and that nesprins function as nuclear cargo adaptors. The importance of achieving and maintaining proper nuclear position is not restricted to muscle fibers, suggesting that the nesprin-dependent recruitment of kinesin-1 to the nuclear envelope through the interaction of a conserved LEWD motif with kinesin light chain might be a general mechanism for cell-type-specific nuclear positioning during development. Summary: Nuclear positioning in developing skeletal muscle cells is dependent on interactions between kinesin light chains and nesprins, which localize kinesin to the nuclear envelope.
Edinburgh Research Explorer Inhibition of 5alpha-reductase activity in late pregnancy decreases gestational length and fecundity and impairs object memory and central progestogen milieu of juvenile rat offspring

Psychological, physical, and/or immune stressors during pregnancy are associated with negative birth outcomes, such as preterm birth and developmental abnormalities. In rodents, prenatal stressors can alter the expression of 5 α -reductase enzymes in the brain and may influence cognitive function and anxiety-type behaviour in the offspring. Progesterone plays a critical role in maintaining gestation. Here it was hypothesised that 5 α -reduced progesterone metabolites influence birth outcomes and/or the cognitive and neuroendocrine function of the offspring. 5 α reduced steroids were manipulated in pregnant Long-Evans rats via administration of vehicle, the 5 α -reduced, neuroactive metabolite of progesterone, 5 α -pregnan-3 α -ol-20-one (3 α ,5 α -THP, allopregnanolone; 10 mg/kg/ml, SC), or the 5 α -reductase inhibitor, finasteride (50 mg/kg/ml, SC), daily from gestational days 17–21. Compared to vehicle or 3 α ,5 α -THP treatment, finasteride, significantly reduced the length of gestation and the number of pups per litter found in the dams’ nests after parturition. The behaviour of the offspring in hippocampus-dependent tasks (object recognition, open field) was examined on post-natal days 28–30. Compared to vehicle-exposed controls, prenatal 3 α ,5 α -THP treatment significantly increased motor behaviour in females compared to males, decreased progesterone content in the medial prefrontal cortex (mPFC) and diencephalon, increased 3 α ,5 α -THP and 17 β -estradiol content in the hippocampus, mPFC, and diencephalon, and significantly increased serum corticosterone concentrations in males and females. Prenatal finasteride treatment significantly reduced object recognition, decreased hippocampal 3 α ,5 α -THP content, increased progesterone concentration in the mPFC and diencephalon, and increased serum corticosterone concentration in female (but not male) juvenile offspring, compared with vehicle-exposed controls. Thus, inhibiting formation of 5 α -reduced steroids during late gestation in rats reduces gestational length, the number of viable pups/litter, and impairs cognitive and neuroendocrine function in the juvenile offspring.
Merolla communication network and interface A million spiking-neuron integrated circuit with a scalable

, 668 (2014); 345 Science et al. Paul A. Merolla communication network and interface A million spiking-neuron integrated circuit with a scalable This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles ): August 7, 2014 www.sciencemag. org (this information is current as of The following resources related to this article are available online at http://www.sciencemag. org/content/345/6197/668.full. html version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag. org/content/suppl/2014/08/06/345.6197. 668.DC1. html can be found at: Supporting Online Material http://www.sciencemag. org/content/345/6197/668.full. html#ref-list-1 , 6 of which can be accessed free: cites 19 articles This article http://www.sciencemag. org/cgi/collection/comp_math Computers, Mathematics subject collections: This article appears in the following
Multiple copies of eukaryotic translation initiation factors in Brassica rapa facilitate redundancy, enabling diversification through variation in splicing and broad-spectrum virus resistance.

Recessive strain-specific resistance to a number of plant viruses in the Potyvirus genus has been found to be based on mutations in the eukaryotic translation initiation factor 4E (eIF4E) and its isoform, eIF(iso)4E. We identified three copies of eIF(iso)4E in a number of Brassica rapa lines. Here we report broad-spectrum resistance to the potyvirus Turnip mosaic virus (TuMV) due to a natural mechanism based on the mis-splicing of the eIF(iso)4E allele in some TuMV-resistant B. rapa var. pekinensis lines. Of the splice variants, the most common results in a stop codon in intron 1 and a much truncated, non-functional protein. The existence of multiple copies has enabled redundancy in the host plant's translational machinery, resulting in diversification and emergence of the resistance. Deployment of the resistance is complicated by the presence of multiple copies of the gene. Our data suggest that in the B. rapa subspecies trilocularis, TuMV appears to be able to use copies of eIF(iso)4E at two loci. Transformation of different copies of eIF(iso)4E from a resistant B. rapa line into an eIF(iso)4E knockout line of Arabidopsis thaliana proved misleading because it showed that, when expressed ectopically, TuMV could use multiple copies which was not the case in the resistant B. rapa line. The inability of TuMV to access multiple copies of eIF(iso)4E in B. rapa and the broad spectrum of the resistance suggest it may be durable.
Conformal geometric algebra for visual servoing of nonholonomic mobile robots

This paper presents a new visual servo controller based on geometric algebra (GA). The controller has an angular and translational components that are designed using rotors and translators. The controller does not require additional calculations or jacobian-like matrices. We modify the controller to regulate a mobile robot with three degrees of freedom controllable by two. The proposed controller is applied to a nonholonomic mobile robot with a camera mounted on it. The position of the robot is regulated from its current position to a desired position using current and desired images. We develop a GA-based Lyapunov function to demonstrate the stability of the controller and we present simulations validating the proposed controller.
An in vitro experiment on the effect of an attempt to create an apical matrix during root canal preparation on coronal leakage and material extrusion.

OBJECTIVE A common approach to creating an apical matrix (apical stop) in the apical dentin is to enlarge the root canal to 3 sizes greater than that of the first file that binds at the working length. The aim of this study was to test the hypothesis that this procedure will reduce the amount of material extruded and the leakage along the apical root fillings. STUDY DESIGN The canals of half of 120 maxillary and mandibular canines were prepared to the apical foramen through use of the serial shaping technique; the apical matrix creation procedure was not used. Each of the other 60 canals was prepared to 1 mm short of the apical foramen, and the canal was enlarged to at least 3 sizes greater than that of the first binding file to create an apical matrix. All the canals prepared with and all the canals prepared without the apical matrix creation procedure were obturated with laterally or vertically compacted cold or warm gutta-percha. In the leakage test, after post space preparation, the amount of fluid transport along the apical root fillings was measured. In the material extrusion test, the number of teeth with gutta-percha extrusion was recorded and the weight of the apically extruded materials was measured. RESULTS In both the leakage and the extrusion tests, no significant difference was found between canals prepared with and canals prepared without the apical matrix creation procedure. CONCLUSION The hypothesis that a procedure to enlarge root canals to 3 sizes greater than that of the first binding file will reduce the amount of filling materials extruded and the leakage was not proved, as our results show.
Rationalizable Implementation

This note studies (full) implementation of social choice functions under complete information in (correlated) rationalizable strategies. The monotonicity condition shown by Maskin (1999) to be necessary for Nash implementation is also necessary under the more stringent solution concept. We show that it is also sufficient under a mild "no worst alternative" condition. In particular, no economic condition is required.
Smart Agents and Sentiment in the Heterogeneous Agent Model

In this paper we extend the original heterogeneous agent model by introducing smart traders and changes in agents' sentiment. The idea of smart traders is based on the endeavor of market agents to estimate future price movements. By adding smart traders and changes in sentiment we try to improve the original heterogeneous agents model so that it provides a closer description of real markets. The main result of the simulations is that the probability distribution functions of the price deviations change significantly when smart traders are added to the model, and they also change significantly when changes in sentiment are introduced. We also use the Hurst exponent to measure the persistence of the price deviations and we find that the Hurst exponent is significantly increasing with the number of smart traders in the simulations. This means that the introduction of the smart traders concept into the model results in significantly higher persistence of the simulated price deviations. On the other hand, the introduction of changing sentiment in the proposed form does not change the persistence of the simulated prices significantly.
Autonomous road vehicle guidance from autobahnen to narrow curves

Autonomous rides on public roads performed by a seeing road vehicle under normal traffic conditions have been demonstrated on German Autobahnen since the beginning of 1992. Meanwhile, the new goal of autonomous driving on roads of lower order has been approached by including the turn-off at intersections. Tests have been performed on a specially designed test track including curves with radii from 35-100 m and an intersection. This paper gives a short overview on the applied algorithms as well as the control structure of the system which was developed at the Universitat der Bundeswehr Munchen. A summary of experimental results for autonomous rides points out the applicability of the approach.
Goals and Design of the Whole Program Optimizer

Software engineering practices such as modularization and information hiding encourage programmers to structure programs as a collection of small modules. Small modules give compilers less information for optimizations and thus penalize performance. We describe the design and implementation of the whole program optimizer (WPO) a framework for doing cross-module optimizations for Modula-3 programs. The WPO operates on a high-level intermediate representation and is thus able to take advantage of high-level information to get fast and efficient analysis and optimizations.
PHOTO-STIMULATORY EFFECT OF LOW ENERGY HELIUM-NEON LASER IRRADIATION ON EXCISIONAL DIABETIC WOUND HEALING DYNAMICS IN WISTAR RATS

Background: Generally, the significances of laser photo stimulation are now accepted, but the laser light facilitates wound healing and tissue repair remains poorly understood. Aims: We have examined the hypothesis that the laser photo stimulation can enhance the collagen production in diabetic wounds using the excision wound model in the Wistar rat model. Methods: The circular wounds were created on the dorsum of the back of the animals. The animals were divided into two groups. The study group (N = 24) wound was treated with 632.8 nm He-Ne laser at a dose of 3-9 J/cm2 for 5 days a week until the wounds healed completely. The control group was sham irradiated. Result: A significant increase in the hydroxyproline content and reduction in the wound size were observed in the study group. The pro-healing actions seem to be due to increased collagen deposition as well as better alignment and maturation. Conclusion: The biochemical analysis and clinical observation suggested that 3-6 J/cm2 laser photo stimulation facilitates the tissue repair process by accelerating collagen production in diabetic wound healing.
Some general phonetic and forensic aspects of speaking tempo

The comparability and compatibility of speech samples is of paramount importance to modern techniques of forensic speaker identification. This principle applies also to factors commonly referred to as speaking tempo, speech rate, speed of utterance, and the like, which may differ considerably as a function of various characteristics of the speaking situation. Consider, for example, a blackmailer's telephone call to a victim, i.e. a spontaneous text, often produced in a dialogic situation, and, on the other hand, a text (even the same text) read aloud from a transcript by a suspect and recorded directly over a microphone in a police station. With respect to speaking tempo the compatibility problem is enhanced by the fact that, other than, for instance, F0 and pitch, it cannot be attributed to a single phonetic parameter on the level of either production or perception. In this study the influence of a number of temporal variables which have been associated with speaking tempo in the literature have been investigated in three speaking conditions considered typical of the forensic setting. Furthermore, the potential influence of the telephone recording situation was investigated, a characteristic feature in the vast majority of speaker identification cases. Results from ten speakers and fifteen listeners indicate that speaking condition but not recording condition does in fact have an influence on speaking tempo in terms of both production and perception, with syllable rate, or rather the amount of pausing contained in this parameter, being the best temporal correlate. On the other hand, articulation rate remains almost entirely unaffected and is also remarkably constant within speakers. Therefore it may be regarded as a promising speaker-specific parameter for forensic speaker identification.
On Oscillation-Free Emergency Navigation via Wireless Sensor Networks

Emergency navigation is an emerging application of wireless sensor networks with significant research and social value. In order to ensure the safe and timely navigation of the evacuees, most of the existing works model navigation as a path-planning problem or movement decision support problem and adopt different metrics, such as the shortest route, the minimum exposure path, and the maximum safe distance. Without sufficient consideration of the dynamics of danger, the existing approaches are likely to cause users to move back and forth during navigation, known as oscillation. Frequent oscillations inevitably result in the user remaining in danger for a longer period of time, amplification of the user's panic, and eventual decrease in the chances of survival. In this paper we take users' oscillations in the dynamic environments into account and quantify the local success rate of navigation using a metric called ENO (Expected Number of Oscillations). We then propose OPEN, an oscillation-free navigation approach that minimizes the probability of oscillation and guarantees the success rate of emergency navigation. We implement OPEN and evaluate its performance through the trace from our system and extensive simulations. The results demonstrate that OPEN outperforms the current state-of-the-art approaches with respect to user safety and navigation efficiency.
TimeFlip: Using Timestamp-Based TCAM Ranges to Accurately Schedule Network Updates

Network configuration and policy updates occur frequently, and must be performed in a way that minimizes transient effects caused by intermediate states of the network. It has been shown that accurate time can be used for coordinating network-wide updates, thereby reducing temporary inconsistencies. However, this approach presents a great challenge; even if network devices have perfectly synchronized clocks, how can we guarantee that updates are performed at the exact time for which they were scheduled? In this paper, we present a practical method for implementing accurate time-based updates, using TimeFlips. A TimeFlip is a time-based update that is implemented using a timestamp field in a ternary content addressable memory (TCAM) entry. TimeFlips can be used to implement atomic bundle updates, and to coordinate network updates with high accuracy. We analyze the amount of TCAM resources required to encode a TimeFlip, and show that if there is enough flexibility in determining the scheduled time, a TimeFlip can be encoded by a single TCAM entry, using a single bit to represent the timestamp, while allowing a very high degree of accuracy.
The effects of pregnancy and treatment with progesterone on the host–parasite relationship of Amplicaecum robertsi Sprent & Mines, 1960, in the mouse

Male mice harboured more third-stage larvae of Amplicaecum robertsi than females; these larvae also grew longer than did those in female mice. Gonadectomy removed the differences, evident between the sexes, in both the numbers recovered and the growth of the third-stage larva, between male and female mice. The worms recovered from the gonadectomized hosts were smaller than those from the intact male and female host. Pregnant female mice harboured more worms than either the male or the non-pregnant female mouse. These worms were also smaller than those from the male and non-pregnant females. There was no difference in the growth of the larvae from gonadectomized and pregnant hosts. The treatment of spayed female mice with progesterone resulted in an increase in the size of worm population as compared with the numbers of worms recovered from intact female mice. The worms from the progesterone-treated spayed females were also longer than those from the spayed female hosts. Treatment of normal female mice with progesterone resulted in an increased recovery of worms compared with the numbers of worms recovered from normal female animals. The worms were stunted but they were of a size comparable to those recovered from pregnant female mice. It is suggested that the increase in the size of worm populations and the stunting of the worms recovered from pregnant female mice is associated with the effects of progesterone in relation to the hormone balance associated with the ovary at the time of pregnancy.
Backpropagation for Interval Patterns Backpropagation for Interval Patterns 1

In 9], the author proposed a modiied architecture of multilayer feedforward neural network which is able to work with and to be adapted to interval training patterns. We analyze this architecture, propose a new one based strictly on the interval arithmetic and give a backpropagation like adaptation algorithm. Possible applications of our architecture are discussed. The role of interval networks in approximate reasoning is emphasized.