Miracle-dz/UniFAR-FTUs huggingface dataset:
HIGHLIGHTED TOPIC Epigenetics in Health and Disease Evidence for microRNA involvement in exercise-associated neutrophil gene expression changes

Evidence for microRNA involvement in exercise-associated neutrophil gene expression changes. J Appl Physiol 109: 252–261, 2010. doi:10.1152/japplphysiol.01291. 2009. —Ex-ercise leads to a rapid change in the proﬁle of gene expression in circulating neutrophils. MicroRNAs (miRNAs) have been discovered to play important roles in immune function and often act to attenuate or silence gene translation. We hypothesized that miRNA expression in circulating neutrophils would be affected by brief exercise. Eleven healthy men (19–30 yr old) performed 10, 2-min bouts of cycle ergometer exercise interspersed with 1-min rest at a constant work equivalent to (cid:1) 76% of maximal oxygen uptake (V˙ O 2max ). We used the Agilent Human miRNA V2 Microarray. A conservative statistical approach was used to determine that exercise signiﬁcantly altered 38 miRNAs (20 had lower expression). Using RT-PCR, we veriﬁed the expression level changes from before to after exercise of seven miRNAs. In silico analysis showed that collectively 36 miRNAs potentially targeted 4,724 genes (2 of the miRNAs had no apparent gene targets). Moreover, when we compared the gene expression changes ( n (cid:2) 458) in neutrophils that have been altered by exercise, as previously reported, with the miRNAs altered by exercise, we identiﬁed three pathways, Ubiquitin-mediated proteolysis, Jak-STAT signaling pathway, and Hedgehog signaling pathway, in which an interaction of miRNA and gene expression was plausible. Each of these pathways is known to play a role in key mechanisms of inﬂammation. Brief exercise alters miRNA proﬁle in circulating neutrophils in humans. These data support the hypothesis that exer-cise-associated changes in neutrophil miRNA expression play a role in neutrophil gene expression in response to physical activity.
The right of refugee students to education: whole school and systemic responses

It is the right of all students to 'fully participate, achieve equitable educational outcomes, and develop skills and knowledge to be active citizens'. Schools and education systems have a responsibility in supporting students to achieve this. This session considers current research into barriers faced by refugee students in 'participating fully' in school and 'achieving equitable outcomes' and discusses challenges experienced by schools in providing adequate and appropriate support. The session will outline Department of Education and Training systemic responses, key initiatives in the area of refugee education and individual school approaches to supporting 'participation and equitable educational outcomes' for refugee students. Dorothy Hoddinott will discuss Holroyd High School's response to the needs of young refugees in a secondary school setting and in their move towards post secondary education and work. Berala Public School will discuss ways their school supports the education and resettlement of newly arrived refugee students and families.
Market Share and Exchange Rate Pass-Through in World Automobile Trade

This paper explores the relationship between exchange rate pass-through and market share for monopolistically competitive exporters. Under fairly general assumptions we show that pass-through should be high for exporters based in a country with a very large share of total destination market sales. For source countries with small and intermediate market shares, the theoretical relationship is potentially nonlinear and sensitive to assumptions about the nature of consumer demand and firm interactions. The model is estimated using a panel data set of automobile exports from France, Germany, Sweden, and the United States to a variety of destinations over the period 1970-1988. The empirical relationship between pass-through and market share is significantly non-linear: pass-through is the lowest when the source country's market share is around 45 percent and it is highest when the source country's share approaches 100 percent.
The Pulse of Humanitarian Assistance

Understanding the complex nature of international humanitarian action-particularly following natural disasters or armed conflicts-has been the mission of this unique series. This book explores the cutting-edge concerns that will affect how assistance is offered in the future.Featuring twelve original essays by leading practitioners, policymakers, and scholars, the book is a state of the field report on problems, threats, and opportunities facing relief efforts in today's world.With contributions from such authorities as Bernard Kouchner, founder of Doctors Without Borders, Charles McCormick, CEO of Save the Children, and physicians, military leaders, field workers, and others, the essays confront the most critical issues facing the delivery of effective relief.The issues include military and civilian cooperation in large-scale disasters, with special attention to the growth of private armies. How traditional nongovernmental organizations and faith-based agencies adapt to newchallenges is also explored. Ways to strengthen security for humanitarian workers, refugees, and internally displaced persons and those in transition after wars are also considered.Bringing together diplomatic, military, medical, legal, political, religious, and ethical perspectives from experiences in Darfur, West Africa, Iraq, Pakistan, and other areas, the essays offer an authoritative inventory of where humanitarian relief has been, and how it must change to save lives and communities in peril.
Co9Se8 Nanoplates as a New Theranostic Platform for Photoacoustic/Magnetic Resonance Dual‐Modal‐Imaging‐Guided Chemo‐Photothermal Combination Therapy

A new theranostic platform is developed based on biocompatible poly(acrylic acid) (PAA)-Co9 Se8 nanoplates. These PAA-Co9 Se8 nanoplates are successfully utilized for photoacoustic imaging (PAI)/magnetic resonance imaging (MRI) dual-modal imaging. Moreover, the PAA-Co9 Se8 -DOX shows pH-responsive chemotherapy and enables the combination of photothermal therapy and chemotherapy to receive superior antitumor efficacy. This work promises further exploration of 2D nanoplatforms for theranostic applications.
An ensemble sinusoidal parameter adaptation incorporated with L-SHADE for solving CEC2014 benchmark problems

An effective and efficient self-adaptation framework is proposed to improve the performance of the L-SHADE algorithm by providing successful alternative adaptation for the selection of control parameters. The proposed algorithm, namely LSHADE-EpSin, uses a new ensemble sinusoidal approach to automatically adapt the values of the scaling factor of the Differential Evolution algorithm. This ensemble approach consists of a mixture of two sinusoidal formulas: A non-Adaptive Sinusoidal Decreasing Adjustment and an adaptive History-based Sinusoidal Increasing Adjustment. The objective of this sinusoidal ensemble approach is to find an effective balance between the exploitation of the already found best solutions, and the exploration of non-visited regions. A local search method based on Gaussian Walks is used at later generations to increase the exploitation ability of LSHADE-EpSin. The proposed algorithm is tested on the IEEE CEC2014 problems used in the Special Session and Competitions on Real-Parameter Single Objective Optimization of the IEEE CEC2016. The results statistically affirm the efficiency and robustness of the proposed approach to obtain better results compared to L-SHADE algorithm and other state-of-the-art algorithms.
Malignant glioma: genetics and biology of a grave matter.

Malignant brain tumors strike deep into the psyche of those receiving and those delivering the diagnosis. Malignant gliomas, the most common subtype of primary brain tumors, are aggressive, highly invasive, and neurologically destructive tumors considered to be among the deadliest of human cancers. In its most aggressive manifestation, glioblastoma (GBM), median survival ranges from 9 to 12 months, despite maximum treatment efforts—a statistical fact that has changed little over several decades of technological advances in neurosurgery, radiation therapy, and clinical trials of conventional and novel therapeutics. Over the same time period, there has been an explosion of knowledge in cancer biology and basic science discovery that has fueled meaningful progress in the treatment of many common human cancers, including those of the breast, lung, and prostate. It is perplexing that therapies used effectively in the treatment of these solid tumors are overwhelmingly ineffective in the treatment of GBM, perhaps reflecting the eccentric biology and cellular origin of this neoplasm. To date, only one new agent has been documented to have modest activity against intermediate-grade gliomas, whereas no effective agents have emerged for the treatment of GBM, despite 20 years of enrolling patients in clinical trials. It is ironic that although a comprehensive view of the genetic lesions encountered in malignant gliomas has been compiled, substantive conceptual and practical barriers remain in assigning functional significance to these genetic changes and in harnessing this basic information into the development of drugs that make a difference in patient care. The history of treating malignant gliomas dates back to the middle of the 19th century and parallels landmark advances in modern surgical technique and the clinical discipline of neurology. The first brain tumor surgery of the modern era was performed in 1884 by Rickman
Optimal tracking performance of MIMO networked control systems with communication constraints

In this paper, we study the optimal tracking performance problem of continuous-time linear multi-input multi-output (MIMO) networked control systems. The unstable and non-minimum phase systems is considered. The output feedback path is subject to quantization noise, additive white Gaussian noise and bandwidth constraints, and encoding and decoding are considered. The reference input is a random signal. The performance is measured through the tracking error energy, and two-parameter controller is considered. The explicit expression of the tracking performance has been obtained. The results show that the unstable poles and non-minimum phase zeros of the plant, the channel noise, bandwidth, quantization noise and coder will aggravate the optimal tracking performance.
Delayed treatment with recombinant human tissue factor pathway inhibitor improves survival in rabbits with gram-negative peritonitis.

To determine whether treatment with recombinant human tissue factor pathway inhibitor (TFPI), an inhibitor of the extrinsic coagulation pathway, can improve survival in a clinically relevant model of gram-negative sepsis, rabbits were given an intraperitoneal inoculation of a suspension containing hemoglobin (40 microg/mL), porcine mucin (150 microg/mL), and viable Escherichia coli O18:K1 (1.0 +/- 0.5 x 10(5) cfu/kg). Treatment with gentamicin (5 mg/kg every 12 h for five doses) was instituted 4 h after induction of peritonitis. At the same time point, rabbits were randomized to receive a 24-h infusion of vehicle or one of three different doses of TFPI. Treatment groups, 7-day survival rates, and significance versus control were as follows: control, 1 of 20; TFPI(LOW DOSE) (0.1 mg/kg, then 1 microg/kg/min), 3 of 12 (P = .14); TFPI(MID DOSE), (0.5 mg/kg, then 5 microg/kg/min), 7 of 12 (P = .002); TFPI(HIGH DOSE) (10 mg/kg, then 10 microg/kg/min), 4 of 13 (P = .04). Thus, delayed treatment with TFPI improves survival in septic rabbits.
The next generation of IC measurement – the digital IC‐landscape

A methodology (based on multi‐dimensional scaling and mathematical statistics) is introduced that reduces the high dimensionality of “IC‐differencing components” into a 3‐D dimensional representation – the digital IC‐landscape. Building and maintaining a digital IC‐landscape supports systematically: pedagogical display of IC complexity, migration of IC‐affecting knowledge, exploratory retrieval of high IC‐efficiency, investment planning and forecasting. In this project, 11 companies – with a total of 20‐64 “essential variables” and “free parameters” – have been analyzed and results of the study reported.
If Entry Strategy and Money go Together, What is the Right Side of the Coin?

The goal of this study is to determine which strategic model, either IO or RBV, allows firms to generate the highest performance on a competitive market. Contrasting with classical studies that mobilize analyses as VARCOMP, we deploy a multi-agent system simulating the behavior of firms adopting RBV or IO strategic models. For an equivalent proportion of both strategic orientations, we study the instant and total performances of the firms on hypercompetitive markets. We show that the performance of best-performing IO firms, measured by the ROA, is higher in the short term, but that RBV firms obtain an average higher sustained performance, in the long term. Moreover, when they are in competition with IO firms on a highly profitable and competitive market, RBV firms which dare to enter such markets obtained generally the highest performance.
Movement Disorders in Children: Definitions, Classifications, and Grading Systems

Disorders that affect movement in children are relatively common. However, they have received little attention, especially when compared with epilepsy and neuromuscular disorders. In this review article, we address the major types of movement disorders that affect children, their clinical characteristics and etiologies, and, when available, the scales used to grade them. A discussion on spasticity, which traditionally is not addressed in reviews of “movement disorders,$quotedblright is also included. (J Child Neurol 2003;18:S1—S8).
Employment Subcenters and Land Values in a Polycentric Urban Area: The Case of Chicago

In some previous empiricial research metropolitan Chicago has been considered as a polycentric urban area. This prior research is reviewed and new results are presented on the identification of employment subcenters and the effects of such subcenters on residential land values. The empirical tests confirm that the O'Hare Airport area has emerged as a significant employment subcenter. Several other employment subcenters exist or have existed in the past, and one subcenter had a positive impact on land values in 1928.
Linking Real Estate Decisions to Corporate Strategy

An organization's real estate decisions will be effective if such decisions support the enterprise's overall business objectives. This result can be achieved only by the explicit consideration of how real estate strategy supports corporate strategy and the substrategies for component elements of the corporation, and then in turn how specific real estate operating decisions support the real estate strategy. This approach provides a context for negotiating competing interests and increases the likelihood that a specific real estate decision will be consistent with the enterprise's overall real estate strategy and thereby support realization of corporate business objectives.
How Charleston got her groove back: A Convention and Visitors Bureau’s response to 9/11

The events of 11th September, 2001 had immediate impact on the tourism industry of the world. For domestic US tourism, overall demand fell by 15 per cent overnight, with hotel rates simultaneously softening by 10 per cent. The industry faced an uncertain future. This paper looks at post-9/11 tourism in Charleston, SC. The city, which suffered an immediate decline following 9/11 steeper than the national average, has since enjoyed a remarkably robust recovery. In reviewing this recovery, the crisis management actions of the Charleston Area Convention and Visitors Bureau are discussed and analysed.
Grey scale image hiding method based on decomposition operation

Capacity is one of the importance factors in the hiding techniques. The challenge facing of the concealment techniques is the inverse relationship between the capacity and quality of stego-image. The Least-Significant-Bit (LSB)-based approach is a popular hiding technique in the spatial domain. Number of methods was proposed to enhance the performance of LSB method. However, the capacity of most hiding approaches especially in spatial domain was little and not enough to hide image in image with same size and type. New disguise algorithm based on decomposition and LSB is proposed in this paper. Distorted image as cover image used in this paper to decrease the effect of increase the capacity. Secret image decomposed by binary bit planes and hide 5 bit most significant bit planes from 8. Bit planes are change in order to avoid the appearance of the scene of secret image in stego-image ordering. Experimental results show that the capacity of proposed method is perfect with high quality of recovered image and strong against statistical analysis.
The Evolution of Technologies in Time and Space: From National and Regional to Spatial Innovation Systems

Complementing existing approaches on national innovation systems (NISs) and regional innovation systems (RISs), the proposed spatial innovation systems (SISs) approach incorporates a focus on the path-dependent evolution of specific technologies as components of technological systems and the intermingling of their technological paths among various locations through time. SISs utilize spatial divisions of labor among several specialized RISs, possibly in more than one NIS. The SIS concept emphasizes the external relations of actors as key elements that transcend all existing systems of innovation. The integrating role of these relations remains inadequately understood to date. This poses a challenge for future research.
International trajectories of Brazilian companies

Purpose – It has been argued in the international business literature that companies begin their internationalization trajectories by entering countries that are geographically and psychically closest to the country in which their home market is located before entering more distant ones. This paper aims to verify whether this assertion is correct for Brazilian companies. If it is correct, the companies would be expected to begin their international expansion in countries within the Latin America region. Not only is this region closest in geographical distance, but also it is most similar to Brazil in many other important dimensions.Design/methodology/approach – This paper is an exploratory and quantitative research undertaken with a sample of 109 national capital companies selected from the 1,000 largest Brazilian companies in 2001 net revenues.Findings – Empirical findings indicate that countries in Latin America have been most frequently chosen by Brazilian companies for their first expansions into inte.
Effect of dark sweet cherry powder consumption on the gut microbiota, short-chain fatty acids, and biomarkers of gut health in obese db/db mice

Cherries are fruits containing fiber and bioactive compounds (e.g., polyphenolics) with the potential of helping patients with diabetes and weight disorders, a phenomenon likely related to changes in the complex host-microbiota milieu. The objective of this study was to investigate the effect of cherry supplementation on the gut bacterial composition, concentrations of caecal short-chain fatty acids (SCFAs) and biomarkers of gut health using an in vivo model of obesity. Obese diabetic (db/db) mice received a supplemented diet with 10% cherry powder (supplemented mice, n = 12) for 12 weeks; obese (n = 10) and lean (n = 10) mice served as controls and received a standard diet without cherry. High-throughput sequencing of the 16S rRNA gene and quantitative real-time PCR (qPCR) were used to analyze the gut microbiota; SCFAs and biomarkers of gut health were also measured using standard techniques. According to 16S sequencing, supplemented mice harbored a distinct colonic microbiota characterized by a higher abundance of mucin-degraders (i.e., Akkermansia) and fiber-degraders (the S24-7 family) as well as lower abundances of Lactobacillus and Enterobacteriaceae. Overall this particular cherry-associated colonic microbiota did not resemble the microbiota in obese or lean controls based on the analysis of weighted and unweighted UniFrac distance metrics. qPCR confirmed some of the results observed in sequencing, thus supporting the notion that cherry supplementation can change the colonic microbiota. Moreover, the SCFAs detected in supplemented mice (caproate, methyl butyrate, propionate, acetate and valerate) exceeded those concentrations detected in obese and lean controls except for butyrate. Despite the changes in microbial composition and SCFAs, most of the assessed biomarkers of inflammation, oxidative stress, and intestinal health in colon tissues and mucosal cells were similar in all obese mice with and without supplementation. This paper shows that dietary supplementation with cherry powder for 12 weeks affects the microbiota and the concentrations of SCFAs in the lower intestinal tract of obese db/db diabetic mice. These effects occurred in absence of differences in most biomarkers of inflammation and other parameters of gut health. Our study prompts more research into the potential clinical implications of cherry consumption as a dietary supplement in diabetic and obese human patients.
Multidrug and Toxic Compound Extrusion-Type Transporters Implicated in Vacuolar Sequestration of Nicotine in Tobacco Roots1[C][W]

Nicotine is a major alkaloid accumulating in the vacuole of tobacco (Nicotiana tabacum), but the transporters involved in the vacuolar sequestration are not known. We here report that tobacco genes (NtMATE1 and NtMATE2) encoding transporters of the multidrug and toxic compound extrusion (MATE) family are coordinately regulated with structural genes for nicotine biosynthesis in the root, with respect to spatial expression patterns, regulation by NIC regulatory loci, and induction by methyl jasmonate. Subcellular fractionation, immunogold electron microscopy, and expression of a green fluorescent protein fusion protein all suggested that these transporters are localized to the vacuolar membrane. Reduced expression of the transporters rendered tobacco plants more sensitive to the application of nicotine. In contrast, overexpression of NtMATE1 in cultured tobacco cells induced strong acidification of the cytoplasm after jasmonate elicitation or after the addition of nicotine under nonelicited conditions. Expression of NtMATE1 in yeast (Saccharomyces cerevisiae) cells compromised the accumulation of exogenously supplied nicotine into the yeast cells. The results imply that these MATE-type proteins transport tobacco alkaloids from the cytosol into the vacuole in exchange for protons in alkaloid-synthesizing root cells.