Miracle-dz/UniFAR-FTUs huggingface dataset:
Associations of Mediterranean Diet and a Posteriori Derived Dietary Patterns with Breast and Lung Cancer Risk: A Case-Control Study

Lung cancer in men and breast cancer in women are the most commonly diagnosed cancers in Poland and worldwide. Results of studies involving dietary patterns (DPs) and breast or lung cancer risk in European countries outside the Mediterranean Sea region are limited and inconclusive. This study aimed to develop a ‘Polish-adapted Mediterranean Diet’ (‘Polish-aMED’) score, and then study the associations between the ‘Polish-aMED’ score and a posteriori-derived dietary patterns with breast or lung cancer risk in adult Poles. This pooled analysis of two case-control studies involved 560 subjects (280 men, 280 women) aged 40–75 years from Northeastern Poland. Diagnoses of breast cancer in 140 women and lung cancer in 140 men were found. The food frequency consumption of 21 selected food groups was collected using a 62-item Food Frequency Questionnaire (FFQ)-6. The ‘Polish-adapted Mediterranean Diet’ score which included eight items—vegetables, fruit, whole grain, fish, legumes, nuts and seeds—as well as the ratio of vegetable oils to animal fat and red and processed meat was developed (range: 0–8 points). Three DPs were identified in a Principal Component Analysis: ‘Prudent’, ‘Non-healthy’, ‘Dressings and sweetened-low-fat dairy’. In a multiple logistic regression analysis, two models were created: crude, and adjusted for age, sex, type of cancer, Body Mass Index (BMI), socioeconomic status (SES) index, overall physical activity, smoking status and alcohol abuse. The risk of breast or lung cancer was lower in the average (3–5 points) and high (6–8 points) levels of the ‘Polish-aMED’ score compared to the low (0–2 points) level by 51% (odds ratio (OR): 0.49; 95% confidence interval (Cl): 0.30–0.80; p < 0.01; adjusted) and 63% (OR: 0.37; 95% Cl: 0.21–0.64; p < 0.001; adjusted), respectively. In the middle and upper tertiles compared to the bottom tertile of the ‘Prudent’ DP, the risk of cancer was lower by 38–43% (crude) but was not significant after adjustment for confounders. In the upper compared to the bottom tertile of the ‘Non-healthy’ DP, the risk of cancer was higher by 65% (OR: 1.65; 95% Cl: 1.05–2.59; p < 0.05; adjusted). In conclusion, the Polish adaptation of the Mediterranean diet could be considered for adults living in non-Mediterranean countries for the prevention of the breast or lung cancers. Future studies should explore the role of a traditional Mediterranean diet fitted to local dietary patterns of non-Mediterranean Europeans in cancer prevention.
Generating Continental Scale Pixel-Based Surface Reflectance Composites in Coastal Regions with the Use of a Multi-Resolution Tidal Model

Generating continental-scale pixel composites in dynamic coastal and estuarine environments presents a unique challenge, as the application of a temporal or seasonal approach to composite generation is confounded by tidal influences. We demonstrate how this can be resolved using an approach to compositing that provides robust composites of multi-type environments. In addition to the visual aesthetics of the images created, we demonstrate the utility of these composites for further interpretation and analysis. This is enabled by the manner in which our approach captures the spatial variation in tidal dynamics through the use of a Voronoi mesh, and preserves the band relationships within the modelled spectra at each pixel. Case studies are presented which include continental-scale mosaics of the Australian coastline at high and low tide, and tailored examples demonstrating the potential of the tidally constrained composites to address a range of coastal change detection and monitoring applications. We conclude with a discussion on the potential applications of the composite products and method in the coastal and marine environment, as well as further development directions for our tidal modelling framework.
Phase Noise in Full-Duplex Radios Using Off-the-Shelf Oscillators

This letter analyzes the effect of phase noise (PN) on digital non-linear self-interference (SI) cancellation for low delay spread non-linear SI channels typical of small form factor in-band full-duplex (IBFD) radios in indoor environments. Use of a shared local oscillator (LO) between the transmit and receive radios is assumed, and it is shown that, in theory, un-cancelled SI due to PN can be reduced by optimizing the relative delay between receive LO path and SI channel. Simulations and measurements from hardware IBFD transceivers using realistic LO phase noise characteristics demonstrate that, for these devices/environments, in practice LO phase noise does not limit digital cancellation when using shared local oscillators.
Electromyographic activity of trunk muscles during therapy using the Bobath Concept

Introduction: Cerebral palsy is a disorder characterized by an abnormal activity, movement and posture development. The Bobath concept is one of the most used methods for the neuropediatric rehabilitation and is based on the acquisition of sensorimotor skills according to the normal sequence of the psychomotor development. Objective: In this study, we explore the relationship between electromyographic signal (EMG) in muscles
Effects of an Exercise Intervention on Cancer-Related Fatigue and Its Relationship to Markers of Oxidative Stress

Background: Although the underlying mechanisms of cancer-related fatigue (CRF) are not fully characterized, treatment-associated oxidative stress may play a role. The purpose of this study was to determine the effect of an exercise intervention on the relationship between CRF and oxidative stress. Methods: Upon cessation of radiation or chemotherapy, 8 cancer patients participated in a 10-week exercise intervention (EX), while 7 continued standard care (CON). Blood draws and fatigue questionnaires were administered to cancer patients before and after the intervention as well as to 7 age-matched individuals with no cancer history. Changes in plasma 8-hydroxy-deoxyguanosine (8-OHdG), protein carbonyls, antioxidant capacity, and fatigue were compared between groups. Correlations between CRF and oxidative stress were evaluated. Results: Mean total fatigue scores decreased significantly (5.0 ± 2.2 to 2.6 ± 1.5, P < .05) in EX, but not in CON. Antioxidant capacity significantly increased (+41%; P < .05) and protein carbonyls significantly decreased (−36%; P < .05) in EX, but not in CON. Increases in antioxidant capacity were significantly correlated with reductions in affective (r = −.49), sensory (r = −.47), and cognitive fatigue (r = −.58). Changes in total (r = .46) and affective (r = .47) fatigue exhibited significant correlations with changes in 8-OHdG over time, while behavioral (r = .46) and sensory (r = .47) fatigue changes were significantly correlated with protein carbonyls. Conclusions: Oxidative stress may be implicated in CRF, while improved antioxidant capacity following an exercise intervention may play a role in mitigating CRF in cancer survivors.
Investor Sentiment and Pre-Ipo Markets

We examine whether irrational behavior among small (retail) investors drives post-IPO prices. We use prices from the grey market (the when-issued market that precedes European IPOs) to proxy for small investors' valuations. High grey market prices (indicating overoptimism) are a very good predictor of first-day aftermarket prices, while low grey market prices (indicating excessive pessimism) are not. Moreover, we find long-run price reversal only following high grey market prices. This asymmetry occurs because larger (institutional) investors can choose between keeping the shares they are allocated in the IPO, and reselling them when small investors are overoptimistic. Copyright 2006 by The American Finance Association.
The relationship between gestational diabetes mellitus and selenoprotein-P plasma 1 (SEPP1) gene polymorphisms

Abstract Our aim is to demonstrate any correlation between gestational diabetes mellitus (GDM) and polymorphism of the selenoprotein P (SEPP1) gene encoding the SEPP1 protein, having a role in the insulin resistance in GDM. Forty pregnant women with GDM and 40 healthy pregnant women were included in the study. In both groups, single nucleotide polymorphisms (SNPs), specifically, rs4987017, rs13154178, rs146125471, rs28919926, and rs16872762 were studied. There was no difference between the groups in terms of polymorphism rs146125471, rs28919926, or rs16872762 (p > .05). There was a significant difference in SNP rs13154178 polymorphism between the two groups (p < .01). When rs13154178 gene polymorphism was compared with AA homozygous individuals, fasting blood glucose levels were significantly higher in carriers of either polymorphism than in those with no polymorphism (p < .001). We suggest rs13154178 gene polymorphism may lead to GDM in the Turkish society.
Regulator of calcineurin-2 is a centriolar protein with a role in cilia length control

ABSTRACT Almost every cell in the human body extends a primary cilium. Defective cilia function leads to a set of disorders known as ciliopathies, which are characterised by debilitating developmental defects that affect many tissues. Here, we report a new role for regulator of calcineurin 2 (RCAN2) in primary cilia function. It localises to centrioles and the basal body and is required to maintain normal cilia length. RCAN2 was identified as the most strongly upregulated gene from a comparative RNAseq analysis of cells in which expression of the Golgi matrix protein giantin had been abolished by gene editing. In contrast to previous work where we showed that depletion of giantin by RNAi results in defects in ciliogenesis and in cilia length control, giantin knockout cells generate normal cilia after serum withdrawal. Furthermore, giantin knockout zebrafish show increased expression of RCAN2. Importantly, suppression of RCAN2 expression in giantin knockout cells results in the same defects in the control of cilia length that are seen upon RNAi of giantin itself. Together, these data define RCAN2 as a regulator of cilia function that can compensate for the loss of giantin function. Summary: RCAN2 is a centriolar protein with roles in ciliary length control and can compensate for loss of function of giantin.
Chapter 2 Regulation of Intraneuronal Trafficking of G-Protein-Coupled Receptors by Neurotransmitters In Vivo

Most neurotransmitters and related drugs modulate neuronal activity through G-protein-coupled receptors (GPCRs), which are synthesized in the endoplasmic reticulum and mature in the Golgi complex. Immunohistochemical studies at the electron microscopic level demonstrate that GPCRs are targeted to the plasma membrane to interact with neurotransmitters. This membrane targeting of GPCRs leads to their presynaptic or postsynaptic distribution and their synaptic or extrasynaptic localization. This determines the sites of neurotransmitter action and thus the putative role of GPCRs in regulation of neuronal activities. Activation of these receptors triggers a cascade of intracellular events that involves a wide variety of effector systems and leads to the modulation of neuronal postsynaptic activity (Koenig and Edwardson 1997; Krueger et al. 1997; Yoburn et al. 2004). In vitro studies have widely demonstrated that the abundance and availability of these receptors at the cell surface is regulated by the neuronal environment and is the result of complex intraneuronal trafficking. The amplitude of neuronal response to the neurochemical environment variations depends on, besides the quantity of released neurotransmitter, the number of postsynaptic receptors (Oakley et al. 1999; Anborgh et al. 2000). This control of the abundance and availability of GPCRs at the neuronal membrane probably contributes to modulation of how neurons respond to their endogenous or exogenous ligands under physiological, pathological or therapeutic conditions. It is possible that the modulation of receptor availability at the plasma membrane is a key event of
A FORMALISM FOR CONTROL OF ADVECTIVE MIXING

Motivated by the problem of microfluidic mixing, the problem of control of advective mixing in Stokes fluid flows is considered. The flow field is assumed to be induced by a finite set of spatially distributed force fields which can be modulated arbitrarily with time. The advection equation for the density field corresponding to some passive material is considered in conjunction with the Stokes fluid flow equations. As part of the cost function, we use a newly developed measure for mixedness of a density field, referred to as the Mix-Norm. Its representation as an inner product on the space of densities makes the problem of advective fluid mixing suitable for control-theoretical tools. Application of the fundamental theorem of the calculus of variations to the finite-time optimal control problem yields a two-point boundary value problem which is numerically solved using a conjugate gradient descent method. We present two examples and numerical results using this formalism. One is a problem involving a double array of vortices and the other is a problem where a parabolic flow profile acts together with a single array of vortices. The optimal control strategies are shown to have a non-trivial structure.
Determinacy and Subsumption of Single-Valued Bottom-Up Tree Transducers

SUMMARY This paper discusses the decidability of determinacy and subsumption of tree transducers. For two tree transducers T 1 and T 2 , T 1 determines T 2 if the output of T 2 can be identiﬁed by the output of T 1 , that is, there is a partial function f such that [[ T 2 ]] = f ◦ [[ T 1 ]] where [[ T 1 ]] and [[ T 2 ]] are tree transformation relations induced by T 1 and T 2 , respectively. Also, T 1 subsumes T 2 if T 1 determines T 2 and the partial function f such that [[ T 2 ]] = f ◦ [[ T 1 ]] can be deﬁned by a transducer in a designated class that T 2 belongs to. In this paper, we show that determinacy is in coNEX-PTIME for single-valued linear extended bottom-up tree transducers as the determiner class and single-valued bottom-up tree transducers as the deter-minee class. We also show that subsumption is in coNEXPITME for these classes, and a bottom-up tree transducer T 3 such that [[ T 2 ]] = [[ T 3 ]] ◦ [[ T 1 ]] can be constructed if T 1 subsumes T 2 .
Association between UCP polymorphisms and adipokines with obesity in Mexican adolescents

Abstract Background: It has been reported that the uncoupling proteins (UCPs) can contribute to energy metabolism, and are thus involved in the pathogenesis of obesity. The objective of the study was to analyze the association between UCP polymorphisms, clinical parameters and leptin and adiponectin plasma levels in an adolescent population with overweight and obesity. Methods: We analyzed the UCP1 -3826 C/T, UCP2-866 G/A, Ala55Val and UCP3 -55 C/T polymorphisms and the levels of adipokines in adolescents with normal weight and with overweight or obesity. The study included 270 students aged between 12 and 18 years categorized according to the percentiles from Mexico City. Adipokines levels were measured by immunoassay methods and the UCP polymorphisms were determined using Taqman real-time polymerase chain reaction (RT-PCR). Results: No significant differences were found in the UCP polymorphisms in seven inheritance models studied. Most of the significant differences in the clinical parameters were found under a recessive model, the UCP2 -866 polymorphism was associated with diastolic blood pressure (p=0.008), triglycerides (p=0.045), low-density lipoprotein-cholesterol (LDL-C) (p=0.003), high-density lipoprotein-cholesterol (HDL-C) (p=0.050) and plasma levels of leptin (p<0.001). Also, the obese group was found to have higher leptin levels and lower adiponectin levels in GA+AA vs. GG (recessive model). Conclusions: This study demonstrated a direct relationship between the clinical characteristics and UCP2-866 in a recessive model, associated with high levels of leptin and decreased levels of adiponectin in an obese or overweight Mexican adolescent population.
Powerful Parallel Symmetric 3D Thinning Schemes Based on Critical Kernels

- They are e(cid:27)e tive and sound, in the sense that they are guaranteed to preserve topology. This guarantee is obtained thanks to a theorem on riti al kernels; - They are powerful, in the sense that they remove more points, in one iteration, than any other symmetri parallel thinning s heme; - They are versatile, as onditions for the preservation of geometri al features (e
Changes in Near-Infrared Spectroscopy After Congenital Cyanotic Heart Surgery

Background Since oxygen saturation from pulse oximetry (SpO2) and partial pressure of arterial oxygen (PaO2) are observed to improve immediately after surgical correction of cyanotic congenital heart disease (CHD), we postulate that cerebral (CrO2) and somatic (SrO2) oximetry also improves immediately post-correction. We aim to prospectively examine CrO2 and SrO2, before, during, and after surgical correction as well as on hospital discharge in children with cyanotic CHD to determine if and when these variables increase. Methods This is a prospective observational trial. Eligibility criteria included children below 18 years of age with cyanotic CHD who required any cardiac surgical procedure. CrO2 and SrO2 measurements were summarized at six time-points for comparison: (1) pre-cardiopulmonary bypass (CPB); (2) during CPB; (3) post-CPB; (4) Day 1 in the pediatric intensive care unit (PICU); (5) Day 2 PICU; and (6) discharge. Categorical and continuous variables are presented as counts (percentages) and median (interquartile range), respectively. Results Twenty-one patients were analyzed. 15 (71.4%) and 6 (28.6%) patients underwent corrective and palliative surgeries, respectively. In the corrective surgery group, SpO2 increased immediately post-CPB compared to pre-CPB [99 (98, 100) vs. 86% (79, 90); p < 0.001] and remained in the normal range through to hospital discharge. Post-CPB CrO2 did not change from pre-CPB [72.8 (58.8, 79.0) vs. 72.1% (63.0, 78.3); p = 0.761] and even decreased on hospital discharge [60.5 (53.6, 62.9) vs. 72.1% (63.0, 78.3); p = 0.005]. Post-CPB SrO2 increased compared to pre-CPB [87.3 (77.2, 89.5) vs. 72.7% (65.6, 77.3); p = 0.001] but progressively decreased during PICU stay to a value lower than baseline at hospital discharge [66.9 (57.3, 76.9) vs. 72.7% (65.6, 77.3); p = 0.048]. Conclusion CrO2 and SrO2 did not increase after corrective surgery of cyanotic CHD even up to hospital discharge. Future larger studies are required to validate these findings. (This study is registered with ClinicalTrials.gov ID: NCT02417259.)
Nanoindentation of Ion Implanted and Deposited Amorphous Silicon

The deformation behavior of both ion-implanted and deposited amorphous Si (a-Si) films has been studied using spherical nanoindentation, followed by analysis using Raman spectroscopy and cross-sectional transmission electron microscopy (XTEM). Indentation was carried out on both unannealed a-Si films (the so-called unrelaxed state) and in ion implanted films that were annealed to 450oC to fully relax the amorphous film. The dominant mode of deformation in unrelaxed films was via plastic flow of the amorphous phase rather than phase transformation, with measured hardness being typically 75–85% of that of crystalline Si. In contrast, deformation via phase transformation was clearly observed in the relaxed state of ion implanted a-Si, with the load-unload curves displaying characteristic discontinuities and Raman and XTEM indicating the presence of high-pressure crystalline phases Si-III and Si-XII following pressure release. In such cases the measured hardness was within 5% of that of the crystalline phase.
BENEFICIAL IMPACTS OF CHOLINE IN ANIMAL AND HUMAN WITH SPECIAL REFERENCE TO ITS ROLE AGAINST FATTY LIVER SYNDROME

Choline exists in feed ingredients and also synthesized in the body. It is essential for the physiological functions such as performance and lowering liver and body fat. If choline is insufficient in the diet, the liver fat content and abdominal fat content increase causing a metabolic disorder known as a fatty liver syndrome. Thus, dietary supplementation of choline as synthetic choline chloride or through natural herbs to the diets is compulsory. Besides fatty liver syndrome, choline deficiency causes loss of hepatocytes, heart diseases, bone and growth development abnormalities and impairment in kidney functions. The main indication of choline deficiency is raised up the level of liver enzymes like alanine transaminase (ALT). This ALT is usually measured clinically during diagnostic evaluation of hepatocellular injury to fix liver health. Lipotropic nutrients like choline could prevent fatty liver disorders through several mechanisms, such as increased hepatic very low-density lipoproteins (VLDL) secretion. Human and animal studies have reported protective impacts of choline for fatty liver disease (FLD) in addition to coronary heart disease (CVD) prevention from epidemiological data. Nowadays, choline supplementation is below the dietary recommendations because of a lack of understanding the importance of this vital nutrient for human and animal health. In the current review article, literature * Corresponding author KEYWORDS
A Comparative Assessment of the Response of Two Species of Cucumber Beetles (Coleoptera: Chrysomelidae) to Visual and Olfactory Cues and Prospects for Mass Trapping

Abstract Spotted (Diabrotica undecimpunctata howardii) and striped (Acalymma vittatum) cucumber beetles (Coleoptera: Chrysomelidae) are serious pests of field-grown cucurbits in most areas of the United States where these crops are grown. This study aimed at quantifying, using a comparative approach, the behavioral response of A. vittatum and D. u. howardii to visual and olfactory cues associated with different trap types. In a first field study, Pherocon corn rootworm (CRW) traps baited with a 5-component floral-based lure (= AgBio lure) captured significantly more A. vittatum than traps baited with any other commercial lure. When used in combination with yellow sticky cards, the AgBio lure outperformed the other lures except for the Trécé lure TRE8274. Subsequent tests revealed that the response of both cucumber beetle species to the AgBio lure was positively associated with increases in the amount of lure used. In the last series of tests that involved color discrimination by the beetles, traps constructed using 3.8-liter jugs painted yellow outperformed the CRW trap. Results from on-farm research, conducted at a commercial vegetable farm, confirmed the beetles' visual preference for yellow, and also revealed an excellent performance of the mass trapping system, which kept cucumber beetle densities in the cash crop below economic thresholds. Combined findings indicate that the mass trapping system developed can be implemented as part of a broader IPM program aimed at managing cucumber beetles.