Miracle-dz/UniFAR-FTUs huggingface dataset:
Plant trait-mediated drag forces on seedlings of four tidal marsh pioneer species

Salt marshes play an important role in coastal protection by reducing the impact of waves and shoreline erosion risks. While mature vegetation is responsible for the persistence and stability of marsh ecosystems, seedling survival of pioneer species is especially crucial for marsh propagation. Marsh seedlings, however, may be threatened by climate change induced increased coastal storm surge intensity and accompanying (extreme) wave conditions, imposing stronger drag forces on marsh seedlings. We test the hypothesis that drag forces experienced by seedlings increase with horizontal orbital velocity (Uw ) in a species-specific manner, and that the drag forces experienced are individual-plant trait-mediated. To test our hypotheses, seedlings of four contrasting pioneer marsh species (Bolboschoenus maritimus, Schoenoplectus tabernaemontani, Spartina anglica, and Puccinellia maritima) were exposed to storm wave conditions in a flume, where Uw and experienced drag forces were measured. Linear mixed effect models demonstrated that seedling’s susceptibility to storm wave conditions is at least partly mediated by individual plant traits. Drag forces experienced by seedlings tended to increase with Uw , and with stem length and diameter. The interplay of both traits was complex, with increasing stem length being the most important trait accounting for increases in drag forces experienced at low to moderate Uw , while the stem diameter became more important with increasing Uw . Furthermore, experienced drag forces appeared to be affected by species-specific traits such as rigidity and leaf growth, being highest for Bolboschoenus maritimus and lowest for Puccinellia maritima. Our results provide important mechanistic insights into the drivers of tidal marsh seedling vulnerability to storm wave conditions due to experienced drag, both based on the traits of individual plants and species-specific ones. This type of knowledge is of key importance when modelling saltmarsh establishment and resilience under climate change.
Relationship between rural land titling and land transfer in China: a systematic literature review and meta-analysis

The traditional land system of rural communities in China has been an obstacle to the sustainable development of land transfer. To facilitate a more efficient allocation of resources, the Chinese government has implemented the largest rural land titling action in the world. However, there has been much debate in scholarly circles regarding the correlation between rural land titling and rural land transactions. By employing meta-analysis technology, this paper evaluates the relationship between rural land titling and rural land transactions. According to the meta-analysis results, rural land titling is only a minor contributor to rural land transfer; it only contributes to rural land transfer-out, with no effect on rural land transfer-in. Furthermore, education, age, labor force, agricultural fixed assets owned, area of contracted rural land, and publication time were identified as situational variables that affect the relationship between rural land titling and rural land transfer-out. This research provides insight into how to promote the sustainable development of agricultural land economy by promoting land transfer, as well as further topics for future study.
Impact of hearing aid technology level at first-fit on self-reported outcomes in patients with presbycusis: a randomized controlled trial

To provide clinical guidance in hearing aid prescription for older adults with presbycusis, we investigated differences in self-reported hearing abilities and hearing aid effectiveness for premium or basic hearing aid users. Secondly, as an explorative analysis, we investigated if differences in gain prescription verified with real-ear measurements explain differences in self-reported outcomes. The study was designed as a randomized controlled trial in which the patients were blinded towards the purpose of the study. In total, 190 first-time hearing aid users (>60 years of age) with symmetric bilateral presbycusis were fitted with either a premium or basic hearing aid. The randomization was stratified on age, sex, and word recognition score. Two outcome questionnaires were distributed: the International Outcome Inventory for Hearing Aids (IOI-HA) and the short form of the Speech, Spatial, and Qualities of Hearing Scale (SSQ-12). In addition, insertion gains were calculated from real-ear measurements at first-fit for all fitted hearing aids. Premium hearing aid users reported 0.7 (95%CI: 0.2; 1.1) scale points higher total SSQ-12 score per item and 0.8 (95%CI: 0.2; 1.4) scale points higher speech score per item, as well as 0.6 (95%CI: 0.2; 1.1) scale points higher qualities score compared to basic-feature hearing aid users. No significant differences in reported hearing aid effectiveness were found using the IOI-HA. Differences in the prescribed gain at 1 and 2 kHz were observed between premium and basic hearing aids within each company. Premium-feature devices yielded slightly better self-reported hearing abilities than basic-feature devices, but a statistically significant difference was only found in three out of seven outcome variables, and the effect was small. The generalizability of the study is limited to community-dwelling older adults with presbycusis. Thus, further research is needed for understanding the potential effects of hearing aid technology for other populations. Hearing care providers should continue to insist on research to support the choice of more costly premium technologies when prescribing hearing aids for older adults with presbycusis. Clinical Trial Registration: https://register.clinicaltrials. gov/, identifier NCT04539847.
Advances in gut microbiome in metabonomics perspective: based on bibliometrics methods and visualization analysis

Background and aims Gastrointestinal microbial metabolomics is closely related to the state of the organism and has significant interaction with the pathogenesis of many diseases. Based on the publications in Web of Science Core Collection(WoSCC) from 2004 to 2022, this study conducted a bibliometric analysis of this field, aiming to understand its development trend and frontier, and provide basic information and potential points for in-depth exploration of this field. Methods All articles on gastrointestinal flora and metabolism published from 2004 to 2022 were collected and identified in WoCSS. CiteSpace v.6. 1 and VOSviewer v.1. 6.15. 0 were used to calculate bibliometric indicators, including number of publications and citations, study categories, countries/institutions, authors/co-cited authors, journals/co-cited journals, co-cited references, and keywords. A map was drawn to visualize the data based on the analysis results for a more intuitive view. Results There were 3811 articles in WoSCC that met our criteria. Analysis results show that the number of publications and citations in this field are increasing year by year. China is the country with the highest number of publications and USA owns the highest total link strength and citations. Chinese Acad Sci rank first for the number of institutional publications and total link strength. Journal of Proteome Research has the most publications. Nicholson, Jeremy K. is one of the most important scholars in this field. The most cited reference is “Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease”. Burst detection indicates that Urine, spectroscopy, metabonomic and gut microflora are long-standing hot topics in this field, while autism spectrum disorder and omics are likely to be at the forefront of research. The study of related metabolic small molecules and the application of gastrointestinal microbiome metabolomics in various diseases are currently emerging research directions and frontier in this field. Conclusion This study is the first to make a bibliometric analysis of the studies related to gastrointestinal microbial metabolomics and reveal the development trends and current research hotspots in this field. This can contribute to the development of the field by providing relevant scholars with valuable and effective information about the current state of the field.
Mitoepigenetics and gliomas: epigenetic alterations to mitochondrial DNA and nuclear DNA alter mtDNA expression and contribute to glioma pathogenicity

Epigenetic mechanisms allow cells to fine-tune gene expression in response to environmental stimuli. For decades, it has been known that mitochondria have genetic material. Still, only recently have studies shown that epigenetic factors regulate mitochondrial DNA (mtDNA) gene expression. Mitochondria regulate cellular proliferation, apoptosis, and energy metabolism, all critical areas of dysfunction in gliomas. Methylation of mtDNA, alterations in mtDNA packaging via mitochondrial transcription factor A (TFAM), and regulation of mtDNA transcription via the micro-RNAs (mir 23-b) and long noncoding RNAs [RNA mitochondrial RNA processing (RMRP)] have all been identified as contributing to glioma pathogenicity. Developing new interventions interfering with these pathways may improve glioma therapy.
Tonic activation of GABAB receptors via GAT-3 mediated GABA release reduces network activity in the developing somatosensory cortex in GAD67-GFP mice

The efficiency of neocortical information processing critically depends on the balance between the glutamatergic (excitatory, E) and GABAergic (inhibitory, I) synaptic transmission. A transient imbalance of the E/I-ratio during early development might lead to neuropsychiatric disorders later in life. The transgenic glutamic acid decarboxylase 67-green fluorescent protein (GAD67-GFP) mouse line (KI) was developed to selectively visualize GABAergic interneurons in the CNS. However, haplodeficiency of the GAD67 enzyme, the main GABA synthetizing enzyme in the brain, temporarily leads to a low GABA level in the developing brain of these animals. However, KI mice did not demonstrate any epileptic activity and only few and mild behavioral deficits. In the present study we investigated how the developing somatosensory cortex of KI-mice compensates the reduced GABA level to prevent brain hyperexcitability. Whole-cell patch clamp recordings from layer 2/3 pyramidal neurons at P14 and at P21 revealed a reduced frequency of miniature inhibitory postsynaptic currents (mIPSCs) in KI mice without any change in amplitude or kinetics. Interestingly, mEPSC frequencies were also decreased, while the E/I-ratio was nevertheless shifted toward excitation. Surprisingly, multi-electrode-recordings (MEA) from acute slices revealed a decreased spontaneous neuronal network activity in KI mice compared to wild-type (WT) littermates, pointing to a compensatory mechanism that prevents hyperexcitability. Blockade of GABAB receptors (GABABRs) with CGP55845 strongly increased the frequency of mEPSCs in KI, but failed to affect mIPSCs in any genotype or age. It also induced a membrane depolarization in P14 KI, but not in P21 KI or WT mice. MEA recordings in presence of CGP55845 revealed comparable levels of network activity in both genotypes, indicating that tonically activated GABABRs balance neuronal activity in P14 KI cortex despite the reduced GABA levels. Blockade of GABA transporter 3 (GAT-3) reproduced the CGP55845 effects suggesting that tonic activation of GABABRs is mediated by ambient GABA released via GAT-3 operating in reverse mode. We conclude that GAT-3-mediated GABA release leads to tonic activation of both pre- and postsynaptic GABABRs and restricts neuronal excitability in the developing cortex to compensate for reduced neuronal GABA synthesis. Since GAT-3 is predominantly located in astrocytes, GAD67 haplodeficiency may potentially stimulate astrocytic GABA synthesis through GAD67-independent pathways.
Social support score in patients with malignant diseases—with sociodemographic and medical characteristics

Introduction Social support as a complex construct has a positive influence not only on a patient’s condition but also on the process of the patient’s emotional adjustment to cancer. The goal of this study is to investigate aspects of the level of social support in oncology patients and its interconnection with sociodemographic and medical variables. Method The study was conducted as a prospective observational study in 2020, including 250 patients aged 19 and over, both sexes, with a diagnosis of oncological disease. The research was conducted in the Department of General Medicine of the Health Center Trstenik, Central Serbia, after approval by the Ethics Committee of the Health Center Trstenik, Central Serbia. A social support assessment questionnaire (Oslo-3 Social Support Scale) was used as a research instrument. Results Data collected from the entire study population showed that bad social support was present in almost 90% of cases. Univariate and multivariate regression analysis showed a statistically significant influence of the following variables on the bad social support: education level, activity limitation, difficulties in performing daily activities, the impact of pain on the performance of activities, the need for additional help with activity, the need for help at home, unfulfilled needs for health care, means of information, anxiety score and depression score. Conclusion Interventions to increase social support may be important for enhancing mental health and quality of life in cancer patients.
OsOLP1 contributes to drought tolerance in rice by regulating ABA biosynthesis and lignin accumulation

Rice, as a major staple crop, employs multiple strategies to enhance drought tolerance and subsequently increase yield. Osmotin-like proteins have been shown to promote plant resistance to biotic and abiotic stress. However, the drought resistance mechanism of osmotin-like proteins in rice remains unclear. This study identified a novel osmotin-like protein, OsOLP1, that conforms to the structure and characteristics of the osmotin family and is induced by drought and NaCl stress. CRISPR/Cas9-mediated gene editing and overexpression lines were used to investigate the impact of OsOLP1 on drought tolerance in rice. Compared to wild-type plants, transgenic rice plants overexpressing OsOLP1 showed high drought tolerance with leaf water content of up to 65%, and a survival rate of 53.1% by regulating 96% stomatal closure and more than 2.5-fold proline content promotion through the accumulation of 1.5-fold endogenous ABA, and enhancing about 50% lignin synthesis. However, OsOLP1 knockout lines showed severely reduced ABA content, decreased lignin deposition, and weakened drought tolerance. In conclusion, the finding confirmed that OsOLP1 drought-stress modulation relies on ABA accumulation, stomatal regulation, proline, and lignin accumulation. These results provide new insights into our perspective on rice drought tolerance.
Design and application of artificial rare L-lysine codons in Corynebacterium glutamicum

Background: L-lysine is widely used in the feed, food, and pharmaceutical industries, and screening for high L-lysine-producing strains has become a key goal for the industry. Methods: We constructed the rare L-lysine codon AAA by corresponding tRNA promoter replacement in C. glutamicum. Additionally, a screening marker related to the intracellular L-lysine content was constructed by converting all L-lysine codons of enhanced green fluorescent protein (EGFP) into the artificial rare codon AAA. The artificial EGFP was then ligated into pEC-XK99E and transformed into competent Corynebacterium glutamicum 23604 cells with the rare L-lysine codon. After atmospheric and room-temperature plasma mutation and induction culture, 55 mutants (0.01% of total cells) with stronger fluorescence were sorted using flow cytometry, and further screened by fermentation in a 96-deep-well plate and 500 mL shaker. Results: The fermentation results showed that the L-lysine production was increased by up to 9.7% in the mutant strains with higher fluorescence intensities, and that the highest screening positive rate was 69%, compared with that in the wild-type strain. Conclusion: The application of artificially constructed rare codons in this study represents an efficient, accurate, and simple method for screening other amino acid-producing microorganisms.
Optimal control of robotic manipulators

This dissertation addresses the problem of finding the desired optimal trajectories and the optimal control inputs for a rigid multi-degrees-of-freedom robotic manipulator in a positioning mode. For a general, highly coupled and nonlinear dynamic model an analytical control law is derived and structures of controllers are suggested. The equations of motion of a multilink mechanism and its actuators are unified into a common dynamic model. A nonlinear feedback transformation which globally linearizes, decouples and places the poles of the closed loop system is derived. Each of the decoupled subsystems represents a single degree of freedom of the manipulator motion. This transformation is realized by on-line computations based on the measurements of the manipulator's state variables and reference to a look-up table, and requires no matrix inversion. The set of uncoupled subsystems in a form of triple integrators allows a solution of various optimal control problems for each degree of freedom independently. The time optimal positioning problem of a multi-degrees-of-freedom robotic manipulator with bounded velocity, acceleration and jerk is posed in a form which guarantees uniqueness of the control and state trajectories. The solution is demonstrated via single and double link examples. The look-up table implementing the feedback transformation introduces non-analytic (quantization) errors. The time optimal trajectories of a double link manipulator are shown to be rather insensitive to this type of error. For a class of errors an existence theorem of the linear feedback controller is proven which guarantees closed loop asymptotic stability at the state space origin. Finally, outlines of various controller structures are discussed. This dissertation is the first application of the following principles: (1) Instead of optimizing the real system, a fictitous system should be introduced which is more convenient for optimization and can be obtained from the original system, for example, by a state space transformation. (2) The state space feedback transformation can be realized for decoupling, linearization and pole-placement simultaneously. (3) The programmed open loop control for a deterministic system can be devised with the assumption that deviations are compensated by a separated subsystem for "control in-the-small. "
A new model for control of systems with friction

In this paper we propose a new dynamic model for friction. The model captures most of the friction behavior that has been observed experimentally. This includes the Stribeck effect, hysteresis, spring-like characteristics for stiction, and varying break-away force. Properties of the model that are relevant to control design are investigated by analysis and simulation. New control strategies, including a friction observer, are explored, and stability results are presented. >
Phase diagrams of exceptional and supersymmetric lattice gauge theories

In this work different strongly-coupled gauge theories with and without fundamental matter have been studied on the lattice with an emphasis on the confinement problem and the QCD phase diagram at nonvanishing net baryon density as well as on possible supersymmetric extensions of the standard model of particle physics. In gauge theories with a non-trivial centre symmetry, as for instance SU(3)-Yang-Mills theory, confinement is intimately related to the centre of the gauge group, and the Polyakov loop serves as an order parameter for confinement. In QCD, this centre symmetry is explicitly broken by quarks in the fundamental representation of the gauge group. But still quarks and gluons are confined in mesons, baryons and glueballs at low temperatures and small densities, suggesting that centre symmetry is not responsible for the phenomenon of confinement. Therefore it is interesting to study pure gauge theories without centre symmetry. In this work this has been done by replacing the gauge group SU(3) of the strong interaction with the exceptional Lie group G2, that has a trivial centre. To investigate G2 gauge theory on the lattice, a new and highly efficient update algorithm has been developed, based on a local HMC algorithm. Employing this algorithm, the proposed and already investigated first order phase transition from a confined to a deconfined phase has been confirmed, showing that indeed a first order phase transition without symmetry breaking or an order parameter is possible. In this context, also the deconfinement phase transition of the exceptional Lie groups F4 and E6 in three spacetime dimensions has been studied. It has been shown that both theories also possess a first order phase transition.
Contributions à la théorie des houles

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Application of Cubic Splines to Contour Plotting

A contour map is a diagram used to represent topography of a land surface by contour curves of equal elevation. This geographical convention can be extended to analyze diverse objects such as an atmospheric pressure field, a stress field in a steel plate, and the variation in the density of debris at an archaeological site [3]. Consider a rectangle R partitioned into m x n rectangular panels of equal size with a regular grid of points (xi, yj) for i = 0, 1. ,m, j = 0,1,. ,n, and a real function f on R whose values at the grid points
Localization of Multi-source UHF Signals Based on Random Matrix Theory

For a power source to be dependable, power equipment must operate safely and steadily. The insulation state of power equipment can be evaluated by the partial discharge (PD) measurement through the widely used ultra-high frequency (UHF) technology. In practical applications, because of the requirements in real-time performance, small snapshot systems are used which may cause the failure of traditional UHF positioning methods in effectively resolving multiple sources with similar angles. Therefore, in this paper, following the Stieltjes correction of the sample covariance matrix’s eigenvalues and eigenvectors, a multi-source PD UHF localization approach based on random matrix theory was presented. From then, the PD source could be located by looking for its spectral peak in a spatial spectrum. According to the simulation findings, the suggested approach can resolve nearby UHF PD sources with fewer snapshots, and the resolution success rate was highly improved.
Ear-to-Ear Propagation Model—Comparison of Free-Space and On-Body Gain Formulations

Two different formulations of the antenna far-field used to evaluate the on-body path gain at 2.45 GHz through a ray-based ear-to-ear propagation model are compared. The free-space far-field formulation does not take field coupling to the human body in the on-body far-field into account, whereas the on-body formulation does. The simulations are compared with a reference full-wave simulation. It is expected that the on-body formulation should improve the accuracy of the propagation model since it takes the field-to-body coupling into account in the on-body far-field. It is found that the results of the comparative study are aligned with expectations. The path gain that results from the use of the on-body far-field formulation is closer to the reference path gain in the band of interest, i.e., around 2.45 GHz.