Miracle-dz/UniFAR-FTUs huggingface dataset:
Mandibular single-implant overdentures: preliminary results of a randomised-control trial on early loading with different implant diameters and attachment systems.

OBJECTIVES To determine surgical and prosthodontic outcomes of mandibular single-implant overdentures, opposing complete maxillary dentures, using a wide diameter implant and large ball attachment system compared with different regular diameter implants with standard attachment systems. MATERIALS AND METHODS Thirty-six edentulous participants (mean age 68 years, SD 9.2) were randomly assigned into three treatment groups (n=12). A single implant was placed in the mandibular midline of participants to support an overdenture using a 6-week loading protocol. The control group received Southern regular implants and standard ball attachments. One group received Southern 8-mm-wide implants and large ball attachments. Another group received Neoss regular implants and Locator attachments. Parametric and non-parametric tests of a statistical software package (SPSS) were used to determine between groups differences in marginal bone loss, implant stability, implant, and prosthodontic success (P<0.05). RESULTS Implant success after 1 year was 75% for Southern regular implant (control) group; and 100% for the Southern wide and Neoss regular implant groups (P=0.038). Mean marginal bone loss at 1 year was 0.19 mm (SD 0.39) without significant differences observed. Implant stability quotient (ISQ) at baseline was significantly lower for the Southern regular (control) group than the other two groups (P=0.001; P=0.009). At 1 year, no significant difference in implant stability was observed (mean ISQ 74.6, SD 6.1). The change in implant stability from baseline to 1 year was significant for the control group (P=0.025). Prosthodontic success was comparable between the groups but the maintenance (41 events overall, mean 1.2) was greater for the Locator and the standard ball attachments. CONCLUSIONS Mandibular single-implant overdentures are a successful treatment option for older edentulous adults with early loading protocol using implants of different diameters and with different attachment systems.
Triple Helix Clusters: Boundary Permeability at University—Industry—Government Interfaces as a Regional Innovation Strategy

With this paper I discuss the importance of permeability among university—industry—government boundaries based on the experience of MIT and Boston, Stanford and Silicon Valley, the Research Triangle and North Carolina, and Newcastle University and Northeast UK. Encouraging permeability in university boundaries is a first step to creating an entrepreneurial university, the driving force of the most successful innovation regions. Underlying drivers of innovation are transferable and may be instituted by specif c policy initiatives addressing gaps in particular cases. These is no one-size-fits-all ‘best-practice’ mode but there are some common characteristics of innovation regimes such as ‘boundary permeability’ that can be positively influenced by explicit measures.
External Imbalances in the Euro Area

The paper examines the extent to which current account imbalances of euro area countries are related to intra-euro area factors and to external trade shocks. We argue that the traditional explanations for the rising imbalances are correct, but are incomplete. We uncover a large impact of declines in export competitiveness and asymmetric trade developments vis-a-vis the rest of the world –in particular vis-a-vis China, Central and Eastern Europe, and oil exporters- on the external balance of euro area debtor countries. While current account imbalances of euro area deficit countries vis-a-vis the rest of the world increased, they were financed mostly by intra-euro area capital inflows (in particular by the purchase of government and financial institutions’ securities, and cross-border interbank lending) which permitted external imbalances to grow over time.
Shape adaptation of long bone structures using a contour based approach

In this work, an approach for mechanically driven shape adaptation of long bone structures is presented which utilizes contour descriptions to track morphological changes at different bone cross sections. A script-based procedure is used to iteratively generate a solid geometry and finite element (FE) model from these contours, perform a stress analysis, and then update the contour shapes using the results of the stress analysis using a prescribed remodeling rule. Because a remeshing operation is performed at each timestep the method is able to effectively simulate large changes in geometry. Several examples of shape adaptation of idealized and geometrically accurate long-bone structures are presented using a variety of remodeling signals and parameters.
Participation in Local Unions: A Comparison of Black and White Members

This article compares the participation of black and white union members in their local unions. Using more detailed measures of union participation than those employed in earlier studies, and focusing on members, not just leaders, the authors find little difference between the extent of participation by blacks and that by whites. This surprising result, which contradicts the finding of previous studies that blacks participate in unions less than whites, holds even with controls for gender, salary, education, number of years as a member, the presence of friends in the union, the strength of a sense of efficacy, confidence in the ability to gain local union office, and the liberalness of attitudes about civil rights.
Determination of bovine lymphocyte responses to extracted proteins of Brucella abortus by using protein immunoblotting

Isolation and identification of Brucella antigenic determinants important to cellular responses have been difficult. In this study, bovine peripheral blood mononuclear (PBM) cells from cattle vaccinated with Brucella abortus 19 proliferated to extracted bacterial proteins blotted onto nitrocellulose. Proteins were extracted from gamma-irradiated B. abortus 19 with a sodium dodecyl sulfate extraction buffer. The extracted proteins were separated electrophoretically by sodium dodecyl sulfate-polyacrylamide gel electrophoresis prior to electroblotting onto nitrocellulose. Nitrocellulose sections corresponding to individual lanes of the gel (containing all separated proteins) were then cultured with the PBM cells. Primary and secondary stimulation responses of the PBM cells with the whole protein blots were similar kinetically to the responses of the PBM cells stimulated with whole irradiated B. abortus 19 or with whole irradiated B. abortus 19 blotted onto nitrocellulose. Although lipopolysaccharide was determined to be associated with the extracted proteins and transferred onto the blots, the lipopolysaccharide did not stimulate cellular proliferation, as indicated by the antigen-specific secondary responses. Stimulating PBM cells with portions of the blot containing high (greater than 45,000)-, medium (25,000 to 45,000)- or low (25,000)-molecular-weight proteins demonstrated that the responding cells were specific only to the proteins of corresponding molecular weights. These results indicate that cellular responses to individual proteins can be studied without cloning the bacterial genes or purifying the individual proteins.
The Effect of Union Characteristics on the Outcome of NLRB Certification Elections

This paper examines the determinants of National Labor Relations Board certification election outcomes in individual election units between 1972 and 1980. Particular emphasis is given to the role of national union characteristics in determining union success or failure. The authors find that union success in organizing both blue- and white-collar workers is influenced positively by union size and internal democracy and negatively by strike activity and the centralization of its decision making. Benefits provided directly to members by unions significantly increase, and higher dues significantly reduce, white-collar organizing success, whereas the same factors have no significant effect on blue-collar organizing.
Uma conspiração multidimensional em torno da indústria de software: argumentos para a intervenção em setores de alta intensidade tecnológica

This paper analyses the current debate about governmental intervention in high tech industries. On one hand, there are arguments against such interventions that consider the high tech industries as a capital intensive sector; instead of technological intensity, the capital intensity determines the value added. On the other hand, we could prove that there is at least one high tech industry, which is job intensive and non capital intensive, with high value added, that generates several positive externalities (the software industry). Such externalities are important arguments to support governmental intervention in high tech industries and cast doubts on the capital’s value added argument.
Change and Continuity

With this issue, The Journal of Ayn Rand Studies begins a collaboration with the Pennsylvania State University Press, which will manage all aspects of design, production, distribution, and subscription fulfillment. In embarking on this new arrangement, the journal unveils a new look, but retains its commitment to introducing new writers to the ever-expanding world of Rand studies.
Are Real Interest Rates Equal Across Countries? an Empirical Investigation of International Parity Conditions

The proposition that real rates are equal across countries is worth studying because it is central to our understanding of open economy macroeconomics and because it is also an important issue to policy makers. If it is true, then domestic monetary authorities have no control over their real rate relative to the world rate, limiting the impact of their stabilization policies. In addition, as Feldstein has pointed out, unless real rates can differ across countries, policies directed at increasing domestic savings cannot increase the rate of capital formation and hence productivity. The equality of real rates is also worth investigating, because it is intimately linked to and provides information on the basic parity conditions featured so prominently in open economy macro models.This paper conducts empirical tests of the equality of real rates and other parity conditions across countries using euro rate data over the1967-II to 1979-II sample period. The empirical evidence strongly rejects the hypothesis of the equality of real euro rates across countries. The joint hypotheses of uncovered interest parity and ex ante relative PPP, or the unbiasedness of forward rate forecasts and ex ante relative PPP, are also strongly rejected. Yet independent tests of uncovered interest parity, the unbiasedness of forward rate forecasts and ex ante relative PPP yield few rejections and high marginal significance levels. The evidence suggests that it is worth studying open economy models which allow: 1) domestic real rates to differ from world rates, 2) time varying risk premiums in the forward market or 3) deviations from ex ante relative purchasing power parity.The evidence also leaves open the possibility for policy makers to exertsome control over their domestic real rate relative to those in the rest of the world. However, the evidence does not rule out that there is a tendency for real rates across countries to equalize over time, and this is an important topic for further research.
PTK7 modulates Wnt signaling activity via LRP6

Protein tyrosine kinase 7 (PTK7) is a transmembrane protein expressed in the developing Xenopus neural plate. PTK7 regulates vertebrate planar cell polarity (PCP), controlling mesodermal and neural convergent-extension (CE) cell movements, neural crest migration and neural tube closure in vertebrate embryos. Besides CE phenotypes, we now show that PTK7 protein knockdown also inhibits Wnt/β-catenin activity. Canonical Wnt signaling caudalizes the neural plate via direct transcriptional activation of the meis3 TALE-class homeobox gene, which subsequently induces neural CE. PTK7 controls meis3 gene expression to specify posterior tissue and downstream PCP activity. Furthermore, PTK7 morphants phenocopy embryos depleted for Wnt3a, LRP6 and Meis3 proteins. PTK7 protein depletion inhibits embryonic Wnt/β-catenin signaling by strongly reducing LRP6 protein levels. LRP6 protein positively modulates Wnt/β-catenin, but negatively modulates Wnt/PCP activities. The maintenance of high LRP6 protein levels by PTK7 triggers PCP inhibition. PTK7 and LRP6 proteins physically interact, suggesting that PTK7 stabilization of LRP6 protein reciprocally regulates both canonical and noncanonical Wnt activities in the embryo. We suggest a novel role for PTK7 protein as a modulator of LRP6 that negatively regulates Wnt/PCP activity.
Comparing in vivo pump–probe and multiphoton fluorescence microscopy of melanoma and pigmented lesions

Abstract. We demonstrate a multimodal approach that combines a pump–probe with confocal reflectance and multiphoton autofluorescence microscopy. Pump–probe microscopy has been proven to be of great value in analyzing thin tissue sections of pigmented lesions, as it produces molecular contrast which is inaccessible by other means. However, the higher optical intensity required to overcome scattering in thick tissue leads to higher-order nonlinearities in the optical response of melanin (e.g., two-photon pump and one-photon probe) that present additional challenges for interpreting the data. We show that analysis of pigment composition in vivo must carefully account for signal terms that are nonlinear with respect to the pump and probe intensities. We find that pump–probe imaging gives useful contrast for pigmented structures over a large range of spatial scales (100 μm to 1 cm), making it a potentially useful tool for tracking the progression of pigmented lesions without the need to introduce exogenous contrast agents.
Impact of Neck Dissection on Quality of Life

Objectives: For decades, the gold standard for treatment of cervical metastasis was radical neck dissection (RND). Current oncologic philosophy allows for treatment of appropriately staged neck disease with modified radical neck dissection (MRND) or selective neck dissection (SND). The purposes of this study were to determine the impact of various forms of neck dissection on patients' quality of life (QOL) and to evaluate the responsiveness of the University of Washington (UW) QOL shoulder domain.
Outside Director Responses to Organizational Decline: Exit, Voice, Loyalty, and Neglect

Using previous theory and research on responses to organisational decline, this paper extends the literature into the boardroom to predict outside director behaviour. In so doing, this paper refocuses the corporate governance research towards individual outside directors as opposed to the traditional focus on the overall board. We argue that this contextual and individualistic focus on outside directors’ behaviour may yield some new and useful insights into the corporate governance literature as well as refine and extend Hirshman's theory of responses to organisational decline.
Communicating diabetes and diets on Twitter - a semantic content analysis

This paper analyses: 1 the semantic content of tweets discussing diabetes and diets: 2 the conversational connections of those tweeting and those being mentioned in the tweets. The content analysis of the tweets aims at mapping what kinds of diets are mentioned in conversations about diabetes and in what context. Our data consists of 9,042 tweets containing the words 'diabetes' and 'diet'. The findings indicate that analysing Twitter conversations can be a fruitful and an efficient way to map public opinions about diabetes and diets, as well as other medical issues that concern many people. The results also showed that many private persons act as diabetes advocates spreading information and news about diabetes and diets. Surveying these topics can be useful for healthcare practitioners; as these are in contact with patients with diabetes, it is important that they are aware of both the most discussed topics and the most common information sources, who are often laymen.
Community Conservation, Inequality and Injustice. Myths of Power in Protected Area Management

The principle of local support states that protected areas cannot survive without the support of their neighbours. It is the dominant motif of much writing about community conservation and the integration of conservation with development. However, we should be sceptical of it for several reasons. First, it implies that the weak can defeat the agendas of the strong. Second, the principle ignores the fact that inequality and injustice tend to be perpetrated about the globe. It is not existence of poverty or injustice that will cause problems for conservation, but their distribution within society. Third, a detailed case study from the Mkomazi Game Reserve in Tanzania shows how conservation can flourish despite local opposition. Advocates of community conservation need to pay more attention to fortress conservation's strengths and especially its powerful myths and repre­sentations. Understanding how inequality and conservation are successfully perpetrated will make it easier to understand the politics of more participatory community conservation projects.
Trauma and melanoma formation: a true association?

Background Little is known about the role of mechanical trauma in the pathogenesis of malignant melanoma. In individual patients, traumatic events have been discussed as a causative factor for the induction of melanoma and diagnosis of melanoma following trauma may raise medico‐legal questions. Objectives To evaluate the relationship between traumatic single or recurrent events and melanoma characteristics. Methods Retrospective questionnaire in 369 melanoma patients. Results A large number of patients (337 of 369; 91·3%) denied an association between a possible traumatic event and melanoma formation. Thirty‐two of 369 patients (8·7%) considered an association of trauma and melanoma formation likely. Of these 32 patients, 22 patients (13 men, nine women) reported a single event, and 10 patients (four men, six women) a persisting irritation. An irritation of a pre‐existing melanocytic naevus was reported by two patients with histologically confirmed melanoma on acquired or congenital naevus. Conclusions As most of the patients who mentioned a trauma in this study suffered from acral melanoma, or melanoma located on the extremities, a history of trauma should be expected more frequently at these body sites. A review of epidemiological, clinical and scientific research indicates that there seems to be no evidence for single or persistent traumatic events as a causative factor for melanoma formation.
Crime Attractors, Generators and Detractors: Land Use and Urban Crime Opportunities

The built environment impacts on the patterns of crime in many different ways. The distribution and clustering of different land uses is thought, on theoretical grounds, to play an important role in where and when crimes occur. This study analysed the patterns of assault and motor vehicle theft in relation to the distribution of land uses across more than 60,000 separate parcels of land in a large British Columbia city. Specific land-use types that concentrate routine human activities in time and space are found to act as major crime generators and attractors. Attention to the distribution of these land-use types across the urban mosaic can substantially reduce the volume of crime associated with design decisions.
A pertussis outbreak among daycare children in Northern Israel: who gets sick?

BACKGROUND An outbreak of pertussis occurred in a daycare center with 87.5% vaccination coverage. OBJECTIVES To assess the effectiveness of the acellular pertussis vaccine and prevention of pertussis after chemoprophylaxis with azithromycin. METHODS We studied 31 daycare children aged 3-5.5 years exposed to a child with pertussis. Nasopharyngeal swabs were obtained for Bordetella pertussis culture and polymerase chain reaction initially, and at days 21 and 60 of follow-up, in cases exhibiting symptoms. RESULTS Of the 31 daycare children 6 (19%) tested positive for 8. pertussis by PCR, 4 of whom had not been vaccinated against the disease. Of the two vaccinated children who contracted pertussis, one had milder symptoms and the other was asymptomatic. The incidence of pertussis was significantly lower in the vaccinated group (2/27) than in the unvaccinated group (4/4) (P = 0.000), with efficacy of the vaccine calculated to be 92.5%. Azithromycin chemoprophylaxis was taken only by 14 of the 25 exposed children (56%). On day 21 follow-up, there was no further laboratory-diagnosed B. pertussis cases in any of the exposed children, regardless of whether or not chemoprophylaxis was taken. CONCLUSIONS Based o the children's clinical manifestations and PCR findings a pertussis outbreak had occurred in the daycare center studied. Our findings support the importance of pertussis vaccination since all the unvaccinated children in the daycare center contracted the infection.
HEMATOLOGY: ISSUES IN THE DIALYSIS PATIENT: Multiple Myeloma in End‐Stage Renal Disease

Multiple myeloma is a common cause of chronic kidney disease (CKD). Patients with myeloma‐related kidney disease but low levels of serum monoclonal proteins can be diagnosed with symptomatic myeloma in a simplified diagnostic classification. The presence and type of renal disease in myeloma is dependent on the light chain secreted. Treatment has recently changed and now includes the use of thalidomide and bisphosphonates. Thalidomide can cause hyperkalemia and bisphosphonates can cause renal failure in patients with CKD. Their use is not contraindicated, but they should be used with caution. High‐dose melphalan with an autologous stem cell transplant is now the standard of care and should not be withheld from patients with CKD, even those on dialysis. This treatment can improve the renal disease, and this is more likely if treatment is started early. In patients with persistent dialysis dependence, renal transplantation can be performed if the patient has a complete remission.