Miracle-dz/UniFAR-FTUs huggingface dataset:
Regional variations in test requiring patterns of general practitioners in Spain

Abstract Objective. To analyze the requesting patterns for a range of laboratory tests ordered in 2009 from eight laboratories providing services to eight health areas, using appropriate indicators. Design. Indicators measured every test request per 1,000 inhabitants, and indicators that measured the number of tests per related test requested by general practitioners were calculated. The savings generated, if each Health Care Department achieved the appropriate indicator standard, were also calculated. Laboratory Information System registers were collected, and indicators were calculated automatically in each laboratory using a data warehouse application. Results. There was a large difference in demand for tests by health areas. The ratio of related tests also showed a great variability. The savings generated if each Health Care Department had achieved the appropriate indicator standard were €172,116 for free thyroxine, €18,289 for aspartate aminotransferase, and €62,678 for urea. Conclusions. Considerable variability exists in general practitioners' demand for laboratory tests.
Consensus fold recognition by predicted model quality

Consensus-based protein structure prediction methods have been proved to be successful in recent CASPs (Critical Assessment of Structure Prediction). By combining several weaker individual servers, a meta server tends to generate better predictions than any individual server. In this paper, we present a Support Vector Machines (SVM) regression-based consensus method for protein fold recognition, which is a key component for high-throughput protein structure prediction and protein functional annotation. Our SVM model extracts the features from a predicted structural model by comparing it to other models generated by all the individual servers and then predicts the quality of this model. Experimental results on several LiveBench data sets show that our consensus method consistently performs better than individual servers. Based on this approach, we have developed a meta server, Alignment by Consensus Estimator (ACE), which is participating in CASP6 and CAFASP4 (Fourth Critical Assessment of Fully Automated Structure Prediction). ACE is available at http://www.cs. uwaterloo.ca/˜l3yu/consensus.htm.
An Energy-Quality Utility-Based Adaptive Scheduling Solution for Mobile Users in Dense Networks

There is an important trend in terms of user expectations of ubiquity in relation to rich media services and increase in number and range of devices with high specifications which enable access to such services, with very ambitious technical requirements. Providing this support is a very challenging issue, especially in urban dense network environments (DenseNet). Diverse solutions have been proposed, including deployment of femtocells in conjunction with the existing infrastructure, but there is still need for new approaches to balance resources and quality in current competitive market. This paper proposes an innovative three-phase adaptive scheduling solution [energy-quality utility-based adaptive scheduling solution (EQUAS)], which performs trade off between service quality and energy efficiency when allocating network resources to mobile users in a DenseNet. Resource allocation is performed according to a utility function that takes into account throughput, device energy consumption, and user mobility. Furthermore, adaptive reallocation is applied to increase network coverage and avoid dropping service. Testing results show how EQUAS outperforms two competitive approaches in terms of energy consumption and efficiency, data throughput, and estimated user satisfaction.
RPT2/NCH1 subfamily of NPH3-like proteins is essential for the chloroplast accumulation response in land plants

Significance The photoreceptor phototropin mediates various blue light-induced responses, including phototropism, chloroplast movement, stomatal opening, and leaf flattening. Two BTB/POZ proteins, NONPHOTOTROPIC HYPOCOTYL 3 (NPH3) and ROOT PHOTOTROPISM 2 (RPT2), were identified as early signaling components in phototropin-mediated phototropism and leaf flattening, and a phototropin substrate, BLUE LIGHT SIGNALING1 kinase, specifically mediates the phototropin-mediated stomatal opening. However, early signaling components in the chloroplast movement remain to be determined. We found that RPT2 and the NPH3/RPT2-like (NRL) protein NRL PROTEIN FOR CHLOROPLAST MOVEMENT 1 (NCH1) redundantly mediate the chloroplast accumulation response but not the avoidance response. Our findings indicate that phototropin-mediated phototropism, leaf flattening, and the chloroplast accumulation response, but not the chloroplast avoidance response and stomatal opening, are mediated by NRL proteins. In green plants, the blue light receptor kinase phototropin mediates various photomovements and developmental responses, such as phototropism, chloroplast photorelocation movements (accumulation and avoidance), stomatal opening, and leaf flattening, which facilitate photosynthesis. In Arabidopsis, two phototropins (phot1 and phot2) redundantly mediate these responses. Two phototropin-interacting proteins, NONPHOTOTROPIC HYPOCOTYL 3 (NPH3) and ROOT PHOTOTROPISM 2 (RPT2), which belong to the NPH3/RPT2-like (NRL) family of BTB (broad complex, tramtrack, and bric à brac) domain proteins, mediate phototropism and leaf flattening. However, the roles of NRL proteins in chloroplast photorelocation movement remain to be determined. Here, we show that another phototropin-interacting NRL protein, NRL PROTEIN FOR CHLOROPLAST MOVEMENT 1 (NCH1), and RPT2 redundantly mediate the chloroplast accumulation response but not the avoidance response. NPH3, RPT2, and NCH1 are not involved in the chloroplast avoidance response or stomatal opening. In the liverwort Marchantia polymorpha, the NCH1 ortholog, MpNCH1, is essential for the chloroplast accumulation response but not the avoidance response, indicating that the regulation of the phototropin-mediated chloroplast accumulation response by RPT2/NCH1 is conserved in land plants. Thus, the NRL protein combination could determine the specificity of diverse phototropin-mediated responses.
Transferencia de estilo en fotografías mediante redes neuronales convolucionales

Nowadays is really easy to take pictures from smartphones, which have increased notoriously its computing performance, so there are many pictures oriented applications. Using Machine Learning techniques, is possible to apply style transfer methods to the pictures getting new artistic images. The idea is based on selecting a master piece of art and a picture to apply the master piece style. Using both images, you can get a new image composed by the content of the picture and the style of the master piece. To achieve that style transfer, it is necessary to apply some concepts and techniques from Computer Vision and Deep Learning.
Integration of Multiple Views for a 3-D Indoor Surveillance System

A conventional surveillance system uses multiple screens to separately display the acquired video streams. It may cause trouble to keep track of the moving targets due to the lack of spatial relationship among the camera views. This paper presents a surveillance system that can integrate multiple video contents into one single comprehensive view. To visualize the monitored area, the proposed system uses planar patches to approximate the 3-D model of the monitored environment and displays the video contents of cameras by applying dynamic texture mapping on the model. Therefore, this system can provide an efficient and practical way for interactive 3-D monitoring of the environment without complicated camera calibration and 3-D model reconstruction procedures. Moreover, the moving objects are extracted through foreground segmentation and then visualized through axis-aligned billboarding. In this way, the proposed system can provide security guards a better situational awareness of the monitored area, including the activities of the tracking targets.
The analysis of double doping polysilicon gate Lightly-doped-drain (LDD) MOSFET

A new type of field effect transistor (FET), the double doping polysilicon gate (DDPG) Lightly-doped-drain (LDD) MOSFET, is proposed and demonstrated. The gate of the DDPG LDD MOSFET adopts gate engineering. This novel gate structure takes advantage of material work function. The arrangement is such that the gate near the source is comprised of P-type polysilicon and the gate near the drain is N-type polysilicon. The model is simulated with a 2-D device simulator MEDICI over wide range of device parameters and bias conditions and we get curves such as electric field, surface potential, threshold voltage and driving current. The simulation result shows that an appropriate threshold voltage can be gotten by changing the doping concentration of polysilicon. Meanwhile, the driving capacity is greatly improved compared with the conventional MOSFET. The process of the structure is not complicated which can be easily achieved today.
Understanding Cool in Computing for African-American Youth

This paper examines challenges and opportunities in designing for “cool” as a goal for user interface design for African American youth. The categories of cool as a design metric were adopted from the definition from Read et al. (2011), including categories highlighted by terms like rebellious, anti-social, retro, authentic, rich, and innovative. We present initial results from discussions with designers who created interfaces for African-American youth, highlighting the cool categories but also exploring terms unique to the target population. We speculate on how “cool” could be used as a critical parameter in user interface design processes. Author
Speech and language therapy in practice: a critical realist account of how and why speech and language therapists in community settings in Scotland have changed their intervention for children with speech sound disorders

Healthcare professionals such as speech and language therapists are expected to change their practice throughout their career. However, from a practice perspective, there is a lack of knowledge around what practice change is, what it really takes, and why there are different trajectories. Consequently, therapists, managers and commissioners lack empirical evidence on which to base decisions about enabling practice change. In addition, intervention researchers lack basic sociological research around implementation that could inform their research designs, reporting and impact. This case-based sociological inquiry, underpinned by critical realist assumptions, was designed to address this knowledge gap. It includes a twostage qualitative synthesis of 53 (then 16) studies where speech and language therapists explained the work of their practice in depth, and a primary qualitative study focused on one professional jurisdiction, children with speech sound difficulties (SSD). Forty two speech and language therapists from three NHS areas and independent practice in Scotland participated in individual interviews or self-organised pairs or focus groups to discuss in depth how and why they had changed their practice with these children. A variety of comparative methods were used to detail, understand and explain this particular aspect of the social world. The resulting theory of SSD practice change comprises six configured cases of practice change (Transforming; Redistributing; Venturing; Personalising; Delegating; Refining) emerging from an evolving and modifiable practice context. The work that had happened across four key aspects of this context (Intervention; Candidacy; Caseload; Service) explained what made each case possible, and how practice had come to be one way rather than another. Among its practical applications, the theory could help services plan more realistic practice change. In addition, the inductively developed layered model of SSD intervention change has the potential to contribute to speech and language therapy education as well as methodological discussions around complex interventions.
Comparison of performance indices for detection of proximity to voltage collapse

The paper proposes a new test function to be used in an existent performance index for detection of proximity to a static voltage collapse point. This test function is based on a reduction of the load flow Jacobian with respect to the critical bus of a system. The test function is compared with known singular values and eigenvalues indices, and with other previously proposed test functions. A thorough analysis of the similarities, advantages, and disadvantages of all these indices and test functions is presented. The techniques are tested and compared on the IEEE 300 bus test system, showing the effect of system characteristics and limits in these indices and functions.
A Predictive Approach for a Real-Time Remote Visualization of Large Meshes

Remote access to large meshes is the subject of studies since several years. We propose in this paper a contribution to the problem of remote mesh viewing. We work on triangular meshes. After a study of existing methods of remote viewing, we propose a visualization approach based on a client-server architecture, in which almost all operations are performed on the server. Our approach includes three main steps: a first step of partitioning the original mesh, generating several fragments of the original mesh that can be supported by the supposed smaller Transfer Control Protocol (TCP) window size of the network, a second step called pre-simplification of the mesh partitioned, generating simplified models of fragments at different levels of detail, which aims to accelerate the visualization process when a client(that we also call remote user) requests a visualization of a specific area of interest, the final step involves the actual visualization of an area which interest the client, the latter having the possibility to visualize more accurately the area of interest, and less accurately the areas out of context. In this step, the reconstruction of the object taking into account the connectivity of fragments before simplifying a fragment is necessary.
Legal notice

This report presents an overview of the drug phenomenon in Europe at the start of the new millennium. The first chapter begins with a discussion of overall drug trends. Specifically, it examines trends in drug use and the consequences including multiple drug use; problem drug use and demand for treatment; drug-related deaths; drug-related infectious diseases; and other morbidity. A discussion of the trends in response to drug use looks at policy and strategy development; prevention; reducing the harmful consequences of drug use; and treatment. Chapter two discusses the prevalence and patterns of drug use. Health consequences of drug use, law-enforcement indicators, and drug-market indicators (seizures, price, and purity) are covered in this chapter. The third chapter explains policy and strategy developments as well as demand-reduction responses as they relate to the drug use problem. Chapter four examines substitution treatment, prosecution of drug-related offenses, and problems facing women drug users and their children. The final chapter discusses the drug problem in Central and Eastern Europe. The prevalence and patterns of use and the responses to the problem are addressed in this chapter. (MKA) Reproductions supplied by EDRS are the best that can be made from the original document.
What does learner speech sound like? A case study on adult learners of isiXhosa

This paper reports on an analysis of isiXhosa speech produced by adult language learners. The learners whose speech was recorded were all acquiring isiXhosa as an additional language and the majority of the students had beginner level oral proficiency skills. The speech samples were produced and recorded during the development of a Mobile Assisted Language Learning (MALL) application to support clinical communication skills training at Stellenbosch University's Faculty of Medicine and Health Sciences. The aim of the application was to provide a means for students to practise their oral skills and improve their pronunciation in isiXhosa. The speech data was processed manually as well as automatically and the results reveal that 30% of the recordings do not contain suitable audio. It was also found that, on average, absolute differences between first language speakers and additional language learners are not good indicators of proficiency. However, automatically derived proficiency measures for the majority of the learners improved during the course of a semester.
Market Assessment of Tuberculosis Diagnostics in Brazil in 2012

Background Improved diagnostics for the diagnosis of tuberculosis (TB) are urgently needed. However, test developers and investors require market size data to support new product development. This study assessed the served available market for TB diagnostics in Brazil in 2012 and the market segmentation in the public and private sectors. Methods Data were collected on test volumes done in the public and private sectors for the diagnosis of latent and active TB, drug susceptibility testing and treatment follow-up. Tests included were tuberculin skin tests, interferon-gamma releases assays, smear microscopy, solid and liquid cultures, nucleic acid amplification tests and phenotypic drug susceptibility tests. The data were collected by means of an electronic survey via the Brazilian State laboratories and from sales information provided by manufacturers. Test costs for the public sector were calculated using a components approach, while costs for the private sector were based on prices paid by patients. The overall market value (expenditure) for the entire country was calculated using the public sector test costs. Results During 2012, an estimated total of 2.4 million TB diagnostic tests were done in Brazil, resulting in an estimated overall market value of USD 17.2 million. The public sector accounted for 91% of the test volumes and 88% of the market value. Smear microscopy was the most commonly test (n = 1.3 million; 55% of total) at an estimated value of USD 3.7 million. Culture overall (n = 302,761) represented 13% of test volumes and 40% (USD 6.9 million) of the market value. On average, USD 208 was spent on TB diagnostics for every notified TB patient in Brazil, in 2012. Conclusion The TB diagnostics market value in Brazil in 2012 was over USD 17 million. These study results will help test developers to understand the current and potential market for replacement or add-on diagnostic technologies.
Pathfinding by neuronal growth cones in grasshopper embryos. I. Divergent choices made by the growth cones of sibling neurons

We are interested in how the growth cones of identified neurons navigate in the central nervous system of the grasshopper embryo. The behavior of identified growth cones was observed as a function of developmental time by (i) periodically removing embryos from synchronized clutches of eggs and (ii) filling identified neurons in the central nervous system with the fluorescent dye Lucifer Yellow. We examined the first six progeny of the identified neuronal precursor cell, neuroblast 7–4: the Q1, Q2, G, C, Q5, and Q6 neurons. Their growth cones extend sequentially upon the same route across the midline of the posterior commissure of the developing ganglionic neuropil. However, after reaching the contralateral side of the neuropil, their growth cones diverge from each other at reproducible, cell-specific choice points. By focusing our attention on one such choice point, at which the growth cone of the G neuron turns anteriorly while the growth cone of its sibling C neuron turns posteriorly, we hope to elucidate the environmental cues which guide individual growth cones.
Standard cell library tuning for variability tolerant designs

In today's semiconductor industry we see a move towards smaller technology feature sizes. These smaller feature sizes pose a problem due to mismatch between identical cells on a single die known as local variation. In this paper a library tuning method is proposed which makes a smart selection of cells in a standard cell library to reduce the design's sensitivity to local variability. This results in a robust IC design with an identifiable behavior towards local variations. Experimental results performed on a widely used microprocessor design synthesized for a high performance timing show that we can achieve a timing spread reduction of 37% at an area increase cost of 7%.
Hyperchaotic behaviour of two bi‐directionally coupled Chua's circuits

In this paper, a non‐linear bi‐directional coupling of two Chua's circuits is presented. The coupling is obtained by using polynomial functions that are symmetric with respect to the state variables of the two Chua's circuits. Both a transverse and a tangent system are studied to ensure a global validity of the results in the state space. First, it is shown that the transverse system is an autonomous Chua's circuit, which directly allows the evaluation of the conditions on its chaotic behaviour, i.e. the absence of synchronization between the coupled circuits. Moreover, it is demonstrated that the tangent system is also a Chua's circuit, forced by the transverse system; therefore, its dynamics is ruled by a time‐dependent equation. Thus, the calculus of conditional Lyapunov exponents is necessary in order to exclude antisynchronization along the tangent manifold.