Miracle-dz/UniFAR-FTUs huggingface dataset:
A Multilayer Naïve Bayes Model for Analyzing User's Retweeting Sentiment Tendency

Today microblogging has increasingly become a means of information diffusion via user's retweeting behavior. Since retweeting content, as context information of microblogging, is an understanding of microblogging, hence, user's retweeting sentiment tendency analysis has gradually become a hot research topic. Targeted at online microblogging, a dynamic social network, we investigate how to exploit dynamic retweeting sentiment features in retweeting sentiment tendency analysis. On the basis of time series of user's network structure information and published text information, we first model dynamic retweeting sentiment features. Then we build Naïve Bayes models from profile-, relationship-, and emotion-based dimensions, respectively. Finally, we build a multilayer Naïve Bayes model based on multidimensional Naïve Bayes models to analyze user's retweeting sentiment tendency towards a microblog. Experiments on real-world dataset demonstrate the effectiveness of the proposed framework. Further experiments are conducted to understand the importance of dynamic retweeting sentiment features and temporal information in retweeting sentiment tendency analysis. What is more, we provide a new train of thought for retweeting sentiment tendency analysis in dynamic social networks.
Differential diagnosis of suspected multiple sclerosis: a consensus approach

Background and objectives Diagnosis of multiple sclerosis (MS) requires exclusion of diseases that could better explain the clinical and paraclinical findings. A systematic process for exclusion of alternative diagnoses has not been defined. An International Panel of MS experts developed consensus perspectives on MS differential diagnosis. Methods Using available literature and consensus, we developed guidelines for MS differential diagnosis, focusing on exclusion of potential MS mimics, diagnosis of common initial isolated clinical syndromes, and differentiating between MS and non-MS idiopathic inflammatory demyelinating diseases. Results We present recommendations for 1) clinical and paraclinical red flags suggesting alternative diagnoses to MS; 2) more precise definition of “clinically isolated syndromes” (CIS), often the first presentations of MS or its alternatives; 3) algorithms for diagnosis of three common CISs related to MS in the optic nerves, brainstem, and spinal cord; and 4) a classification scheme and diagnosis criteria for idiopathic inflammatory demyelinating disorders of the central nervous system. Conclusions Differential diagnosis leading to MS or alternatives is complex and a strong evidence base is lacking. Consensus-determined guidelines provide a practical path for diagnosis and will be useful for the non-MS specialist neurologist. Recommendations are made for future research to validate and support these guidelines. Guidance on the differential diagnosis process when MS is under consideration will enhance diagnostic accuracy and precision.
Organizational-professional conflict of I/O psychologists, job satisfaction and work engagement

organizational-professional conflict occurs among employees in situations when organizational expectations and demands are opposed to the professional principles and standards. The results of studies have shown that this conflict negatively affects employees' attitude towards the job and affective-motivational state of fulfilment with work role. The purpose of this research was to examine exposure to organizational-professional conflict among I/O psychologists in Serbia, to find out whether there is a correlation between the exposure to organizational-professional conflict, job satisfaction and work engagement, and to determine the main factors of exposure to organizational-professional conflict. Our sample consisted of 96 I/O psychologists. Results have shown that there was significant high negative correlation between the exposure to organizational-professional conflict and job satisfaction, as well as significant moderate negative correlation between the exposure to organizational-professional conflict and work engagement. The highest correlations were with social dimensions of job satisfaction. The exposure to organizational-professional conflict was lower among I/O psychologists with longer work experience and those at higher positions in organizational hierarchy. The exposure to organizational-professional conflict was higher among I/O psychologists who were working in privately owned companies and among those who were fixed-term employees. There was no significant correlation between the exposure to organizational-professional conflict and the size of the organization or business field. Our study showed that organizational-professional conflict should be considered as an important theoretical and research topic, as well as a relevant professional and career issue.
Pronunciation by Analogy: Impact of Implementational Choices on Performance

Pronunciation by analogy (PbA) is an emerging, data-driven technique with potential application in text-to-speech (TTS) systems, as well as being an influential psychological model of reading aloud. The underlying idea is that a pronunciation for an unknown word (i.e., one not in the dictionary, or lexicon, of the human or machine “reader”) is assembled by matching substrings of the input to substrings of known, lexical words, hypothesizing a partial pronunciation for each matched substring from the lexical knowledge of the “reader,” and concatenating the partial pronunciations. This paper assesses the capability of PbA to derive pronunciations for unknown words of English. As a psychological model, PbA is “under-specified,” that is, the implementor of a simulation of the process faces detailed choices which can only be resolved by trial and error. One goal for this paper is to explore the impact of certain basic implementational choices on the performance of PbA systems. The variables studied are the specific lexical database used as the basis of the analogy process, the way of ranking/scoring candidate pronunciations, and the effect of manual versus automatic alignment of letters and phonemes. When tested with short (monosyllabic) pseudowords previously used in experimental psychology studies, the lowest error rate achieved is 14.3% (for a test set of size 70). We conclude that current PbA systems are at best poor models of pseudoword pronunciation by humans. To assess their suitability for use in a TTS application, in which multisyllabic words will be encountered, the implementations have also been tested with lexical words temporarily removed from the dictionary. The best performance obtained was 93.5% phonemes correct (corresponding to 67.9% words correct) for a 16,280-word dictionary. This is vastly superior to the 25.7% words correct obtained using a set of popular letter-to-sound rules, indicating considerable scope for analogy methods to be exploited in future TTS systems.
Interorgan Crosstalk Contributing to β-Cell Dysfunction

Type 2 diabetes mellitus (T2DM) results from pancreatic β-cell failure in the setting of insulin resistance. In the early stages of this disease, pancreatic β-cells meet increased insulin demand by both enhancing insulin-secretory capacity and increasing β-cell mass. As the disease progresses, β-cells fail to maintain these compensatory responses. This involves both extrinsic signals and mediators intrinsic to β-cells, which adversely affect β-cells by impairing insulin secretion, decreasing proliferative capacities, and ultimately causing apoptosis. In recent years, it has increasingly been recognized that changes in circulating levels of various factors from other organs play roles in β-cell dysfunction and cellular loss. In this review, we discuss current knowledge of interorgan communications underlying β-cell failure during the progression of T2DM.
Building Social Capital Through Microfinance

A number of development assistance programs promote community interaction as a means of building social capital. Yet, despite strong theoretical underpinnings, the role of repeat interactions in sustaining cooperation has proven difficult to identify empirically. We provide the first experimental evidence on the economic returns to social interaction in the context of microfinance. Random variation in the frequency of mandatory meetings across first-time borrower groups generates exogenous and persistent changes in clients' social ties. We show that the resulting increases in social interaction among clients more than a year later are associated with improvements in informal risk-sharing and reductions in default. A second field experiment among a subset of clients provides direct evidence that more frequent interaction increases economic cooperation among clients. Our results indicate that group lending is successful in achieving low rates of default without collateral not only because it harnesses existing social capital, as has been emphasized in the literature, but also because it builds new social capital among participants.
Studies on Drug Interactions between CYP 3 A 4 Inhibitors and Glucocorticoids by

8 INTRODUCTION . 9 REVIEW OF THE LITERATURE.10 1. Drug metabolism.10 1.1. Principles of drug metabolism.10 1.2. The CYP enzymes.10 1.3. CYP3A subfamily . 11 1.4. Drug interactions . 14 1.5. Drug interactions mediated by inhibition of CYP3A4 . 16 1.6. CYP3A4 inhibitors studied . 17 1.6. 1. Itraconazole.17 1.6. 2. Diltiazem.18 1.6. 3. Mibefradil.20 1.6. 4. Grapefruit juice . 21 1.7. CYP3A4 and P-glycoprotein.24 2. Glucocorticoids.24 2.1. General . 24 2.2. Regulation of cortisol secretion.27 2.3. Pharmacodynamics.27 2.4. Therapeutic use . 28 2.5. Adverse effects of glucocorticoid treatment.30 2.6. Methylprednisolone.30 2.7. Prednisolone.33 2.8. Dexamethasone . 35 AIMS OF THE STUDY . 38 MATERIALS AND METHODS . 39 1. Ethical considerations . 39 2. Study subjects . 39 3. Study protocol.39 3.1. Study design . 39 3.2. Determination of plasma drug and cortisol concentrations . 42 3.3. Pharmacokinetic calculations . 43 3.4. Pharmacodynamic measurements.44 3.5. Statistical methods.45 3.6. Archiving.45
The detection of diffuse emission in HCG 16 with XMM-Newton

We report results obtained from analysis of the XMM-Newton observation of the compact group of galaxies HCG 16. It is a peculiar system composed of 7 spirals, 6 of which are active, and its nature as a bound system has been much debated. The EPIC camera observations give new insights into the X-ray parameters describing the physical status of the group. We detect diffuse X-ray emission with a rather elliptical morphology which extends to at least a radius of 135 h −1 50 kpc from the group centre. The spectrum within this region is well modelled by a thermal plasma with a temperature of 0.49 ± 0.17 keV, and a non-zero metallicity. We measure a bolometric X-ray luminosity of 9.6×10 40 h −2 50 erg s −1 which may be only a small fraction of the total luminosity because of the limit in spatial detection arising from the high background level. Despite its low temperature and luminosity, HCG 16 obeys the LX −T relation obtained for brighter galaxy groups even if it lies in a very extreme position. The properties of the diffuse emission confirm the bound nature of HCG 16 even if the gas trapped in the potential well may not yet be virialized. This reopens the debate about the real nature of spiral-dominated galaxy groups, and on their role in a more general cosmological context.
Genetic Landscape of Open Chromatin in Yeast

Chromatin regulation underlies a variety of DNA metabolism processes, including transcription, recombination, repair, and replication. To perform a quantitative genetic analysis of chromatin accessibility, we obtained open chromatin profiles across 96 genetically different yeast strains by FAIRE (formaldehyde-assisted isolation of regulatory elements) assay followed by sequencing. While 5∼10% of open chromatin region (OCRs) were significantly affected by variations in their underlying DNA sequences, subtelomeric areas as well as gene-rich and gene-poor regions displayed high levels of sequence-independent variation. We performed quantitative trait loci (QTL) mapping using the FAIRE signal for each OCR as a quantitative trait. While individual OCRs were associated with a handful of specific genetic markers, gene expression levels were associated with many regulatory loci. We found multi-target trans-loci responsible for a very large number of OCRs, which seemed to reflect the widespread influence of certain chromatin regulators. Such regulatory hotspots were enriched for known regulatory functions, such as recombinational DNA repair, telomere replication, and general transcription control. The OCRs associated with these multi-target trans-loci coincided with recombination hotspots, telomeres, and gene-rich regions according to the function of the associated regulators. Our findings provide a global quantitative picture of the genetic architecture of chromatin regulation.
Chondroitin Sulfate Proteoglycans and Microglia Prevent Migration and Integration of Grafted Müller Stem Cells into Degenerating Retina

At present, there are severe limitations to the successful migration and integration of stem cells transplanted into the degenerated retina to restore visual function. This study investigated the potential role of chondroitin sulfate proteoglycans (CSPGs) and microglia in the migration of human Müller glia with neural stem cell characteristics following subretinal injection into the Lister hooded (LH) and Royal College of Surgeons (RCS) rat retinae. Neonate LH rat retina showed minimal baseline microglial accumulation (CD68‐positive cells) that increased significantly 2 weeks after transplantation (p < .001), particularly in the ganglion cell layer (GCL) and inner plexiform layer. In contrast, nontransplanted 5‐week‐old RCS rat retina showed considerable baseline microglial accumulation in the outer nuclear layer (ONL) and photoreceptor outer segment debris zone (DZ) that further increased (p < .05) throughout the retina 2 weeks after transplantation. Marked deposition of the N‐terminal fragment of CSPGs, as well as neurocan and versican, was observed in the DZ of 5‐week‐old RCS rat retinae, which contrasted with the limited expression of these proteins in the GCL of the adult and neonate LH rat retinae. Staining for CSPGs and CD68 revealed colocalization of these two molecules in cells infiltrating the ONL and DZ of the degenerating RCS rat retina. Enhanced immune suppression with oral prednisolone and intraperitoneal injections of indomethacin caused a reduction in the number of microglia but did not facilitate Müller stem cell migration. However, injection of cells with chondroitinase ABC combined with enhanced immune suppression caused a dramatic increase in the migration of Müller stem cells into all the retinal cell layers. These observations suggest that both microglia and CSPGs constitute a barrier for stem cell migration following transplantation into experimental models of retinal degeneration and that control of matrix deposition and the innate microglial response to neural retina degeneration may need to be addressed when translating cell‐based therapies to treat human retinal disease.
Associations Between Maternal Helminth and Malaria Infections in Pregnancy and Clinical Malaria in the Offspring: A Birth Cohort in Entebbe, Uganda

Background. Helminth and malaria coinfections are common in the tropics. We investigated the hypothesis that prenatal exposure to these parasites might influence susceptibility to malaria in childhood. Methods. In a birth cohort of 2345 mother–child pairs in Uganda, maternal helminth and malaria infection status was determined during pregnancy, and childhood malaria episodes were recorded from birth to age 5 years. We examined associations between maternal infections and malaria in the offspring. Results. Common maternal infections were hookworm (45%), Mansonella perstans (21%), Schistosoma mansoni (18%), and Plasmodium falciparum (11%). At age 5 years, 69% of the children were still under follow-up. The incidence of malaria was 34 episodes per 100 child-years, and the mean prevalence of asymptomatic malaria at annual visits was 5.4%. Maternal hookworm and M. perstans infections were associated with an increased rate of childhood clinical malaria (adjusted hazard ratio [aHR], 1.24, 95% confidence interval [CI], 1.10–1.41; aHR, 1.20, 95% CI, 1.05–1.38, respectively). S. mansoni infection had no consistent association with childhood malaria. Conclusions. This is the first report of an association between helminth infections in pregnancy and malaria in the offspring and indicates that helminth infections in pregnancy may increase the burden of childhood malaria morbidity.
Microstrip patch sensor for measurement of the permittivity of homogeneous dielectric materials

An application of a small air-spaced coaxially fed rectangular microstrip patch antenna as a sensor for permittivity measurement is presented. The models used for the calculation of the permittivity from the shift in the resonant frequency for solid and liquid materials are described. The models are experimentally verified by measurements for several liquid and solid samples. The results are compared with those obtained using standard techniques, namely, coaxial probe and waveguide cell measurements. An error correction technique for the elimination of the systematic error of the measurement is also included.
DISTRIBUTION OF SAGE-GROUSE IN NORTH AMERICA

Abstract We revised distribution maps of potential presettlement habitat and current populations for Greater Sage-Grouse (Centrocercus urophasianus) and Gunnison Sage- Grouse (C. minimus) in North America. The revised map of potential presettlement habitat included some areas omitted from previously published maps such as the San Luis Valley of Colorado and Jackson area of Wyoming. Areas excluded from the revised maps were those dominated by barren, alpine, and forest habitats. The resulting presettlement distribution of potential habitat for Greater Sage-Grouse encompassed 1 200 483 km2, with the species' current range 668 412 km2. The distribution of potential Gunnison Sage-Grouse habitat encompassed 46 521 km2, with the current range 4787 km2. The dramatic differences between the potential presettlement and current distributions appear related to habitat alteration and degradation, including the adverse effects of cultivation, fragmentation, reduction of sagebrush and native herbaceous cover, development, introduction and expansion of invasive plant species, encroachment by trees, and issues related to livestock grazing. Distribución de Centrocercus spp. en América del Norte Resumen. Revisamos los mapas de distribución potencial precolombino y de poblaciones actuales de Centrocerus urophasianus y C. minimus en América del Norte. El mapa modificado de hábitat potencial precolombino incluyó algunas áreas omitidas de mapas anteriormente publicados, como el Valle San Luis de Colorado y el área de Jackson, Wyoming. Las áreas excluídas de los mapas modificados fueron las dominadas por hábitats forestales, alpinos y estériles. La distribución precolombina resultante para C. urophasianus abarcó 1 200 483 km2, con un territorio actual de 668 412 km2. La distribución de habitat potencial para C. minimus abarcó 46 521 km2, con un territorio actual de 4787 km2. Estos contrastes tan marcados parecen estar relacionados con la modificación y degradación del hábitat, incluyendo los efectos nocivos de la agricultura, la fragmentación de hábitat, la disminución de Artemisia spp. y otras coberturas herbáceas nativas, el desarollo, la introducción y la expansión de especies de plantas invasoras, la invasión de árboles y cuestiones relacionadas con pastoreo de ganado.
Effect of respiration on the solutions of forward and inverse electrocardiographic problems - a simulation study

The forward problem of electrocardiography aims at obtaining a better understanding of cardiac electrophysiological activities, by means of computer modeling and simulation. Whereas, the inverse electrocardiographic problem provides a direct insight of electrical sources into the heart without interventional procedures. Nowadays, the forward and inverse problems are mostly solved in static models, which do not take into account heart motion and respiration. Besides heart motion, neglecting respiration may also lead to remarkable uncertainties in both forward and inverse solutions. In the present work a dynamic lung model is developed. With this model the effect of respiration on the forward and inverse solutions is studied.
Method to calibrate the skeleton model using orientation sensors

This paper introduces a skeleton calibration method for orientation measurement sensors based motion capture systems. In this method, the orientation sensors are used to measure the posture of the limbs. A template is used to register the end-effectors' postures (feet, hands for example). Through capturing the limb postures while the end-effectors match with the pre-defined postures on the template, a linear equation system of the skeleton dimensions can be generated based on the human kinematics. The limb dimension parameters can be optimized based on that. The identifiablility of this skeleton dimension is discussed. The symmetric property of the skeleton is also taken into consideration. To demonstrate the method, IMU sensors and a footprint template are used to calibrate the lower limb dimension. Results show the absolute dimension errors can be controlled within centimeter level for this human lower limb calibration. Compared with existing methods, this template based method is a quick and self-contained method which does not need extra measurement devices, and the skeleton model does not have asymmetric problems. Since the inertial MoCap systems are widely used nowadays, this method is useful to generate an accurate skeleton model for precise behavior presentation.
Mixed-order compositing for 3D paintings

We present a method for rendering 3D paintings by compositing brush strokes embedded in space. The challenge in compositing 3D brush strokes is reconciling conflicts between their z-order in 3D and the order in which the strokes were painted, while maintaining temporal and spatial coherence. Our algorithm smoothly transitions between compositing closer strokes over those farther away and compositing strokes painted later over those painted earlier. It is efficient, running in O(n log n) time, and simple to implement. We demonstrate its effectiveness on a variety of 3D paintings.
Productivity loss of Japanese patients with rheumatoid arthritis – A cross-sectional survey

Abstract Objective: The objective of this study was (1) to determine productivity costs due to absenteeism and presenteeism among Japanese workers with rheumatoid arthritis (RA), and (2) to identify additional factors associated with productivity loss among workers with RA. Methods: An online survey of 500 RA Japanese patients was used. The Japanese version of the Stanford Health Assessment Questionnaire (J-HAQ) was used to measure patients’ functional disability. The patient health questionnaire-9 item (PHQ-9) was used to measure symptoms and severity of depression. To assess work productivity the ‘work productivity and activity impairment questionnaire’ for rheumatoid arthritis (WPAI-RA), a six-item validated instrument was used. Results: Percentages of absenteeism and presenteeism were found to be 1% and 23%, respectively. The annual combined productivity costs of both absenteeism and presenteeism was 7877 USD per patient. Factors significantly associated with a higher productivity loss were functional disability, depressive symptoms, and time since RA diagnosis, while age, and biological disease-modifying antirheumatic drugs (bDMARDs) treatment were significantly associated with a lower productivity loss. Conclusion: Treatment of RA with bDMARDs would likely result in decreased productivity loss among Japanese patients.