Miracle-dz/UniFAR-FTUs huggingface dataset:
Are hepatic portal venous system components distributed equally in the liver? A multidetector computerized tomography study.

OBJECTIVE We aimed to evaluate the relationships between the splenic index, right and left hepatic lobe volumes, diameters of splenic vein (SV), superior mesenteric vein (SMV) and the portal vein (PV) by Multidetector Computerized Tomography (MDCT). We also investigated indirect signs of portal venous flow pattern using these parameters. MATERIAL AND METHODS Following their contrast thoracoabdominal and abdominal 64-MDCT examinations, the images of 100 cases (61 males and 39 females) were evaluated retrospectively. For each case, the splenic index, total hepatic volume, left and right hepatic volumes were calculated on the post-contrast portal venous phase (50(th) sec) images. Spearman correlation tests were carried out with the purpose of determining the relationships between the variables. Statistical significance level was set at p<0.005. RESULTS A statistically significant relation was demonstrated between the diameter of the SMV and right hepatic lobe volume (p<0.0001), and according to Pearson's correlation analysis, a positive correlation of medium strength (r=0.36) was observed. A positive correlation was demonstrated between the diameter of the splenic vein and left hepatic lobe volume (r=0.36). Statistically significant relation between the diameters of the splenic vein and right hepatic lobe was not observed (p=0.62). A strong correlation between the left hepatic lobe volume and the splenic index (r=0.556) was observed. CONCLUSION We observed a positive correlation and a significant relation between the diameter of the SMV and the right hepatic lobe, and a relation between the splenic vein and splenic index and both hepatic lobes. We believe that this situation is related to the streamline flow in the portal vein, and as demonstrated in the literature, the flow in the SMV is directed at the right lobe, whereas the splenic vein empties into the liver homogenously. Our study is the first study in the literature performed by multidetector CT, which is a technique that reveals the relations between the streamline flow in the portal vein, the splenic index and the hepatic lobe volumes.
Life Course Dietary Patterns and Bone Health in Later Life in a British Birth Cohort Study

Evidence for the contribution of individual foods and nutrients to bone health is weak. Few studies have considered hypothesis‐based dietary patterns and bone health. We investigated whether a protein‐calcium‐potassium–rich (PrCaK‐rich) dietary pattern over the adult life course, was positively associated with bone outcomes at 60 to 64 years of age. Diet diaries were collected at ages 36, 46, 53, and 60 to 64 years in 1263 participants (661 women) from the MRC National Survey of Health and Development. DXA and pQCT measurements were obtained at age 60 to 64 years, including size‐adjusted bone mineral content (SA‐BMC) and volumetric bone mineral density (vBMD). A food‐based dietary pattern best explaining dietary calcium, potassium, and protein intakes (g/1000 kcal) was identified using reduced rank regression. Dietary pattern Z‐scores were calculated for each individual, at each time point. Individual trajectories in dietary pattern Z‐scores were modeled to summarize changes in Z‐scores over the study period. Regression models examined associations between these trajectories and bone outcomes at age 60 to 64 years, adjusting for baseline dietary pattern Z‐score and other confounders. A consistent PrCaK‐rich dietary pattern was identified within the population, over time. Mean ± SD dietary pattern Z‐scores at age 36 years and age 60 to 64 years were –0.32 ± 0.97 and 2.2 ± 1.5 (women) and –0.35 ± 0.98 and 1.7 ± 1.6 (men), respectively. Mean trajectory in dietary pattern Z‐scores ± SD was 0.07 ± 0.02 units/year. Among women, a 0.02‐SD unit/year higher trajectory in dietary pattern Z‐score over time was associated with higher SA‐BMC (spine 1.40% [95% CI, 0.30 to 2.51]; hip 1.35% [95% CI, 0.48 to 2.23]), and vBMD (radius 1.81% [95% CI, 0.13 to 3.50]) at age 60 to 64 years. No statistically significant associations were found in men. During adulthood, an increasing score for a dietary pattern rich in protein, calcium, and potassium was associated with greater SA‐BMC at fracture‐prone sites in women. This study emphasizes the importance of these nutrients, within the context of the whole diet, to bone health. © 2016 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research (ASBMR).
Synthesis and bulk acoustic wave properties on the dual mode frequency shift of solidly mounted resonators

This study focused on the fabrication and the theoretical analysis of solidly mounted resonators (SMR) concerning dual-mode frequency responses and their frequency shift of bulk acoustic wave (BAW) resonance. For this device fabrication, RF/DC magnetron sputtering and photolithography were employed to constitute the required multilayer structure. For the theoretical analysis, the dual- mode frequency shift was characterized by the Sauerbrey's formula, and a modified formula was carried out following the trend for the large frequency shift. In the fabrication of the SMR device, Mo/SiO2 was chosen to construct the Bragg reflector as the high/low acoustic impedance materials, respectively, and aluminum nitride (AlN) was used as a piezoelectric layer. To investigate the characteristics of BAW on the dual-mode frequency shift, the c-axis tilted angle of AlN was altered as well as the various mass loading on the SMR. Based on the experimental results, the dual-resonance frequencies showed a nonlinear decreasing trend with a linear increase of the mass loading. Therefore, a modified formula was carried out. Furthermore, the ratio of the longitudinal-resonant frequency to the shear-resonant frequency remained at a range around 1.76 despite the various c-axis tilted angles of AlN and gradual mass loading on the SMR. The electromechanical coupling coefficient, keff 2, of the shear resonance rose with the increase of the c-axis tilted angle of AlN.
A UWB imaging system to detect early breast cancer in heterogeneous breast phantom

This paper presents an experimental early breast cancer detection system in terms of heterogeneous breast phantom. The system consists of commercial Ultrawide-Band (UWB) transceivers and our developed Neural Network (NN) based Pattern Recognition (PR) software for imaging. A simple way to construct cancer- tissue and heterogeneous breast phantom using available low cost materials and their mixtures is also proposed here. The materials are: (i) A mixture of petroleum jelly, soy oil, wheat flour and water as heterogeneous tissue; (ii) A particular glass as skin; and (iii) A specific mixture of water and wheat flour as cancer- tissue. All the materials and their mixtures are considered according to the ratio of the dielectric properties of the breast tissues. To experimentally detect cancer, the UWB signals are transmitted from one side of the breast phantom and received from opposite side diagonally. By using discrete cosine transform (DCT) of the received signals, a Neural Network (NN) is trained, tested and interfaced with the UWB transceiver to form the complete system. The achieved detection rate of cancer cell's existence, size and location are approximately 100%, 93.1% and 93.3% respectively.
How do meiotic chromosomes meet their homologous partners?: lessons from fission yeast

Homologous chromosome pairing is required for proper chromosome segregation and recombination during meiosis. The mechanism by which a pair of homologous chromosomes contact each other to establish pairing is not fully understood. When pairing occurs during meiotic prophase in the fission yeast, Schizosaccharomyces pombe, the nucleus oscillates between the cell poles and telomeres remain clustered at the leading edge of the moving nucleus. These meiosis‐specific activities produce movements of telomere‐bundled chromosomes. Several lines of evidence suggest that these movements facilitate homologous chromosome pairing by aligning homologous chromosomes and promoting contact between homologous regions. Since telomere clustering and nuclear or chromosome movements in meiotic prophase have been observed in a wide range of eukaryotic organisms, it is suggested that telomere‐mediated chromosome movements are general activities that facilitate homologous chromosome pairing. BioEssays 23:526–533, 2001. © 2001 John Wiley & Sons, Inc.
Together or alone? Foraging strategies in Caenorhabditis elegans

A central goal in Life Sciences is to understand how genes encode behaviour and how environmental factors influence the expression of the genes concerned. To reach this goal a combined ecological, molecular biological and physiological approach is required in combination with a suitable model organism. Such an approach allows the elucidation of all parts of the complicated chain of events that lead from induction of gene expression to behaviour, i.e. from environmental stimulus, sensory organs and extracellular and intracellular neuronal signal processing to activation of effector organs. A particularly good model species with which to take this approach is the nematode Caenorhabditis elegans, as it has been described in great detail at the genomic, cellular and behavioural levels. Different strains of C. elegans display prominent behavioural variation in foraging behaviour. Some strains will form social feeding groups when subjected to certain environmental stimuli, while others do not. This variation is due to the existence of just two isoforms of the gene npr‐1, namely 215F and 215V. Here, we describe these behavioural variations at the molecular and cellular levels to attempt to determine the environmental inputs that cause aggregation of these small nematodes. As many different stimuli affect aggregation either positively or negatively, aggregation behaviour seems to be displayed when it improves survival chances. However, not much is known about the ecological context in which C. elegans lives. Investigation of the habitats of different strains of C. elegans would help us to understand why and how a specific foraging strategy enhances survival. The relatively well‐understood molecular pathways that direct its social feeding behaviour make C. elegans a highly suitable model organism to test ecological and behavioural hypotheses about the mechanisms that differentiate between aggregation and solitary behaviours.
Seminal fluid of honeybees contains multiple mechanisms to combat infections of the sexually transmitted pathogen Nosema apis

The societies of ants, bees and wasps are genetically closed systems where queens only mate during a brief mating episode prior to their eusocial life and males therefore provide queens with a lifetime supply of high-quality sperm. These ejaculates also contain a number of defence proteins that have been detected in the seminal fluid but their function and efficiency have never been investigated in great detail. Here, we used the honeybee Apis mellifera and quantified whether seminal fluid is able to combat infections of the fungal pathogen Nosema apis, a widespread honeybee parasite that is also sexually transmitted. We provide the first empirical evidence that seminal fluid has a remarkable antimicrobial activity against N. apis spores and that antimicrobial seminal fluid components kill spores in multiple ways. The protein fraction of seminal fluid induces extracellular spore germination, which disrupts the life cycle of N. apis, whereas the non-protein fraction of seminal fluid induces a direct viability loss of intact spores. We conclude that males provide their ejaculates with efficient antimicrobial molecules that are able to kill N. apis spores and thereby reduce the risk of disease transmission during mating. Our findings could be of broader significance to master honeybee diseases in managed honeybee stock in the future.
The following Figure Is a Genetic Interaction Network That Represents the Synthetic the Predictions for Tc Interactions from Ssl Pairs Involving Sgs1 Let G2-g22, G23 and G24 Denote Plo32, Asf1, Slx4, …. Rad27 and Top1

lethal/sick interactions determined by SGA analysis (Tong et al., 2001). Here genes are represented as nodes, and interactions are represented as edges that connect the nodes; 291 interactions and 204 genes are shown. Among these eight groups, inferring whether there is any TC or TD interactions of the SSL pairs involving the 51 genes in the lower two groups, linked to SGS1 and RAD27, and if yes, TC or TD interactions are of interest. (clockwise in the following SGS1-SSL network). Since TC/TD interactions only exist in these SSL pairs, we set the influences Wj for non-SSL gene pairs to zero, and let W2-W24 be the influence of G2-G24 on SGS1 as follows. (A1) SGS1(t)= 24 12 () (1) (). K kk ii ki F t W G tt λε == + −+ ∑∑ Among these 23 SSL gene pairs, we have q-RT-PCR results on 14 pairs only. SSEM predicts that SGS1 has TC interactions with ASF1, SLX4, WSS1, ESC4, SIS2,
Towards Attack-Resilient Geometric Data Perturbation

Data perturbation is a popular technique for privacypreserving data mining. The major challenge of data perturbation is balancing privacy protection and data quality, which are normally considered as a pair of contradictive factors. We propose that selectively preserving only the task/model specific information in perturbation would improve the balance. Geometric data perturbation, consisting of random rotation perturbation, random translation perturbation, and noise addition, aims at preserving the important geometric properties of a multidimensional dataset, while providing better privacy guarantee for data classification modeling. The preliminary study has shown that random geometric perturbation can well preserve model accuracy for several popular classification models, including kernel methods, linear classifiers, and SVM classifiers, while it also revealed some security concerns to random geometric perturbation. In this paper, we address some potential attacks to random geometric perturbation and design several methods to reduce the threat of these attacks. Experimental study shows that the enhanced geometric perturbation can provide satisfactory privacy guarantee while still well preserving model accuracy for the discussed data classification models.
Women of Color in Academe: Living with Multiple Marginality

Analysis of data from the 1993 National Survey of Postsecondary Faculty shows that faculty value teaching over research. At the same time, the explicit reward structure of academe favors research and publication, rewarding "productivity" in these arenas with money and status. Implications of this disconnect between values and rewards for faculty careers, for policy, and for practice are examined.
Power-performance system-level exploration of a MicroSPARC2-based embedded architecture

This paper describes the architectural exploration of the system-level parameters for a MicroSPARC2-based embedded system. The overall goal of the exploration task is to quickly identify the best architecture of the embedded system in terms of both energy and delay parameters, avoiding a comprehensive analysis of the architectural design space. The energy-delay product (EDP) has been adopted as the evaluation metric to compare the alternative architectures in terms of different cache memory and bus subsystems. The exploration phase adopts an iterative local-search algorithm based on the sensitivity analysis of the cost function with respect to the tuning parameters of the system architecture. The exploration targets the architectural optimisation of the parameters related to the cache memory and the bus sub-systems of an embedded architecture based on the MicroSPARC2 architecture executing the set of Mediabench benchmarks for multimedia applications. The experimental results have shown a reduction up to nine orders of magnitude of the number of design alternatives analyzed during the exploration phase.
Can insulin signaling pathways be targeted to transport Aβ out of the brain?

Although the causal role of Amyloid-β (Aβ) in Alzheimer’s disease (AD) is unclear, it is still reasonable to expect that lowering concentrations of Aβ in the brain may decrease the risk of developing the neurocognitive symptoms of the disease. Brain capillary endothelial cells forming the blood-brain barrier (BBB) express transporters regulating the efflux of Aβ out of the cerebral tissue. Age-related BBB dysfunctions, that have been identified in AD patients, might impair Aβ clearance from the brain. Thus, targeting BBB outward transport systems has been suggested as a way to stimulate the clearance of Aβ from the brain. Recent data indicate that the increase in soluble brain Aβ and behavioral impairments in 3×Tg-AD mice generated by months of intake of a high-fat diet can be acutely reversed by the administration of a single dose of insulin. A concomitant increase in plasma Aβ suggests that clearance from the brain through the BBB is a likely mechanism for this rapid effect of insulin. Here, we review how BBB insulin response pathways could be stimulated to decrease brain Aβ concentrations and improve cognitive performance, at least on the short term.
Hierarchical Verication of the Implementation of The IEEE-754 Table-Driven Floating-Point Exponential Function using HOL

The IEEE-754 floating-point standard, used in nearly all floating-point applications, is considered one of the most important standards. Deep datapath and algorithm complexity have made the verification of such floating-point units a very hard task. Most simulation and reachability analysis verification tools fail to verify a circuit with a deep datapath like most industrial floating-point units. Theorem proving, however, offers a better solution to handle such verification. In this report we have formalized and verified a hardware implementation of the IEEE-754 Table-Driven floating-point exponential function algorithm using the HOL theorem prover. The high ability of abstraction in the HOL verification system allows its use for the verification task over the whole design path of the circuit, starting from the gate level implementation of the circuit up to a higher level behavioral specification. To achieve this goal, we have used both hierarchical and modular approaches for modeling and verifying the floatingpoint exponential function in HOL.
How Global is Globalization

This paper outlines the paradoxes in the rather fragmented process of globalization and the contradiction between the inclusiveness of the concept and its exclusive processes and practices aligned with the global power structure. One major assertion related to education is that we put more effort into screening vast majorities out of education and we intentionally limit the participation of certain individuals and groups from benefiting from the present state of epistemology and axiology. The paper concludes that for universal inclusion, we need a totally new frame that merits the name „global‟and allows the contribution of cherishing the contribution of each and every human being.
Addressing the Complexity of Mobile App Design in Hospital Setting with a Tailored Software Development Life Cycle Model

Recent studies on workflow processes in hospital settings have shown that, since the introduction of EHRs, care-providers spend an increasing amount of their time on documentation rather than on bedside patient care. In order to improve the bedside work process and facilitate bedside documentation, we are developing an evidence-based mobile app for healthcare providers. In this paper, we present a tailored software development life cycle model that we created and validated during the design and development of this smartphone application.
Suicidal Behaviour and Related Risk Factors among School-Aged Youth in the Republic of Benin

Introduction Research on factors associated with suicidal ideation and suicide attempts has been conducted largely in developed countries. Research on West African countries in particular is lacking. Methods Data were obtained from the Global School-based Health Survey conducted in Benin in 2009. This was a cross-sectional study of three grades, spanning Junior and Senior High, which sampled a total of 2,690 adolescents. Data on the occurrence of demographic, psycho-social and socio-environmental risk factors were tested using multinomial logistic regression for their association with suicidal ideation and suicide attempts. Results The survey indicated that 23.2% had thought about suicide and 28.3% had made a suicide attempt in the previous year. Anxiety, loneliness, being bullied, alcohol misuse, illicit drug use, and lack of parental support were independently related to the ideation outcomes, suicidal ideation without planning and suicidal ideation with planning. Multinomial regression analysis, using one suicide attempt and multiple suicide attempts as outcomes, revealed that female sex, anxiety, loneliness, being physically attacked, and illicit drug use were associated these outcomes. Discussion The prevalence of suicide attempts reported in the survey is relatively high. It is possible that there are cultural factors that could explain this finding. Our research indicates that many factors are related to the occurrence of suicidal ideation and suicide attempts among youth in Benin. Illicit drug use and violence in particular are associated with a high rate of suicide attempts in Benin. Measures to address these issues may reduce the risk of self-inflicted violence.
New Molecular and Biological Mechanism of Antitumor Activities of KW-2478, a Novel Nonansamycin Heat Shock Protein 90 Inhibitor, in Multiple Myeloma Cells

Purpose: The heat shock protein 90 (Hsp90) plays an important role in chaperoning oncogenic client proteins in multiple myeloma (MM) cells, and several Hsp90 inhibitors have shown antitumor activities both in vitro and in vivo. However the precise mechanism of action of Hsp90 inhibitor in MM has not been fully elucidated. Experimental Design: We evaluated the antitumor activities of KW-2478, a nonansamycin Hsp90 inhibitor, in MM cells with various chromosomal translocations of immunoglobulin heavy chain (IgH) loci both in vitro and in vivo. Results: Our studies revealed that exposure of KW-2478 to MM cells resulted in growth inhibition and apoptosis, which were associated with degradation of well-known client proteins as well as a decrease in IgH translocation products (FGFR3, c-Maf, and cyclin D1), and FGFR3 was shown to be a new client protein of Hsp90 chaperon complex. In addition, KW-2478 depleted the Hsp90 client Cdk9, a transcriptional kinase, and the phosphorylated 4E-BP1, a translational inhibitor. Both inhibitory effects of KW-2478 on such transcriptional and translational pathways were shown to reduce c-Maf and cyclin D1 expression. In NCI-H929 s.c. inoculated model, KW-2478 showed a significant suppression of tumor growth and induced the degradation of client proteins in tumors. Furthermore, in a novel orthotopic MM model of i.v. inoculated OPM-2/green fluorescent protein, KW-2478 showed a significant reduction of both serum M protein and MM tumor burden in the bone marrow. Conclusions: These results suggest that targeting such diverse pathways by KW-2478 could be a promising strategy for the treatment of MM with various cytogenetic abnormalities. Clin Cancer Res; 16(10); 2792–802. ©2010 AACR.