Miracle-dz/UniFAR-FTUs huggingface dataset:
L1–L2 asymmetry in animacy effects in the processing of Japanese relative clause

Abstract Using self-paced reading, this study investigated the role of head animacy in the processing of Japanese relative clauses (RCs). Second language (L2) learners whose first languages (L1) are English and Korean, and Japanese native speakers participated. The results showed that for native speakers, inanimate heads diminished the processing difficulty associated with object RCs. However, head animacy did not have an effect on L2 processing. The Korean group showed the subject-object asymmetry but no effect of head animacy. The English group did not demonstrate the effect of RC type or head animacy. The overall pattern of these results suggests that L2 learners of Japanese are not guided by syntactic and lexical-semantic information in the same way as Japanese native speakers. These findings are interpreted within the constraint-satisfaction models (MacDonald et al., 1994) and are further discussed in the light of the research concerning the transfer of L1 processing routines.
Oil shale processing as a source of aquatic pollution: monitoring of the biologic effects in caged and feral freshwater fish.

The biologic effects of the oil shale industry on caged rainbow trout (Oncorhynchus mykiss) as well as on feral perch (Perca fluviatilis) and roach (Rutilus rutilus) were studied in the River Narva in northeast Estonia. The River Narva passes the oil shale mining and processing area and thus receives elevated amounts of polycyclic aromatic hydrocarbons (PAHs), heavy metals, and sulfates. The effects of the chemical load were monitored by measuring cytochrome P4501A (CYP1A)-dependent monooxygenase (MO) activities [7-ethoxyresorufin O-deethylase and aryl hydrocarbon hydroxylase (AHH)] as well as conjugation enzyme activities [glutathione S-transferase (GST) and UDP-glucuronosyltransferase] in the liver of fish. CYP1A induction was further studied by detecting the amount and occurrence of the CYP1A protein. Histopathology of tissues (liver, kidney, spleen, and intestine) and the percentage of micronuclei in fish erythrocytes were also determined. Selected PAHs and heavy metals (Cd, Cu, Hg, and Pb) were measured from fish muscle and liver. In spite of the significant accumulation of PAHs, there was no induction of MO activities in any studied fish species. When compared to reference samples, AHH activities were even decreased in feral fish at some of the exposed sites. Detection of CYP1A protein content and the distribution of the CYP1A enzyme by immunohistochemistry also did not show extensive CYP1A induction. Instead, GST activities were significantly increased at exposed sites. Detection of histopathology did not reveal major changes in the morphology of tissues. The micronucleus test also did not show any evidence of genotoxicity. Thus, from the parameters studied, GST activity was most affected. The lack of catalytic CYP1A induction in spite of the heavy loading of PAHs was not studied but has been attributed to the elevated content of other compounds such as heavy metals, some of which can act as inhibitors for MOs. Another possible explanation of this lack of induction is that through adaptation processes the fish could have lost some of their sensitivity to PAHs. Either complex pollution caused by oil shale processing masked part of the harmful effects measured in this study, or oil shale industry did not have any severe effects on fish in the River Narva. Our study illustrates the difficulties in estimating risk in cases where there are numerous various contaminants affecting the biota. ImagesFigure 1Figure 2
Using latent semantic indexing for morph-based spoken document retrieval

Previously, phone-based and word-based approaches have been used for spoken document retrieval. The former suffers from high error rates and the latter from limited vocabulary of the recognizer. Our method relies on unlimited vocabulary continuous speech recognizer that uses morpheme-like units discovered in an unsupervised manner. The morpheme-like units, or “morphs” for short, have been successfully used also as index terms. One problem using morphs as index terms is that the segmentation does not always separate the same stem for different inflected forms of the same word. This resembles the problem of synonyms. In this paper, we apply latent semantic indexing to morph based retrieval. The idea is to project morphs that correspond to the same word, as well as other semantically related terms, to the same dimension. The results show clear improvements in Finnish spoken document retrieval performance. Index Terms: spoken document retrieval, latent semantic indexing, morpheme segmentation.
Complete Genome Sequence of Bacillus subtilis subsp. subtilis Strain 3NA

ABSTRACT Bacillus subtilis 3NA reaches high cell densities during fed-batch fermentation and is an interesting target for further optimization as a production strain. Here, we announce the full genome of B. subtilis 3NA. The presence of specific Bacillus subtilis 168 and W23 genetic features suggests that 3NA is a hybrid of these strains.
Entropy scaling laws for diffusion.

2 /8ρσ the Enskog and Boltzmann diffusion coefficients [3], χ the contact value of the pair correlation function, se the excess entropy per particle, and A = 2.5. Using the excess entropy se/kB = −(4η − 3η )/(1 − η) and contact value χ = (2 − η)/2(1 − η) given by the Carnahan-Starling equation of state [4] (η = πρσ/6 packing fraction), we test this relation against the molecular dynamics simulation results of Erpenbeck and Wood (EW)[5] Fig. 1. The disagreement is quite significant and more important the behavior of the two curves is very different, as (D/DE)EW is not a monotonically decreasing function of (−se/kB). The discrepancy cannot be attributed to the authors use of an approximation for the excess entropy. The idea of entropy scaling for transport coefficients has a fairly long history [6]. Arguing on the basis of the molecular “caging” effect Dzugutov [2] proposed the scaling law:
Cross-Lingual Topic Discovery From Multilingual Search Engine Query Log

Today, major commercial search engines are operating in a multinational fashion to provide web search services for millions of users who compose search queries by different languages. Hence, the search engine query log, which serves as the backbone of many search engine applications, records millions of users’ search history in a wide spectrum of human languages and demonstrates a strong multilingual phenomenon. However, with its salience, the multilingual nature of a search engine query log is usually ignored by existing works, which usually consider query log entries of different languages as being orthogonal and independent. This kind of oversimplified assumption heavily distorts the underlying structure of web search data. In this article, we pioneer in recognition of the multilingual nature of a query log and make the first attempt to cross the language barrier in query logs. We propose a novel model named Cross-Lingual Query Log Topic Model (CL-QLTM) to analyze query logs from a cross-lingual perspective and derive the latent topics of web search data. The CL-QLTM comprehensively integrates web search data in different languages by collectively utilizing cross-lingual dictionaries, as well as the co-occurrence relations in the query log. In order to relieve the efficiency bottleneck of applying the CL-QLTM on voluminous query logs, we propose an efficient parameter inference algorithm based on the MapReduce computing paradigm. Both qualitative and quantitative experimental results show that the CL-QLTM is able to effectively derive cross-lingual topics from multilingual query logs and spawn a wide spectrum of new search engine applications.
Antitumor effects of interferon-omega: in vivo therapy of human tumor xenografts in nude mice.

The antitumor effect of the type I IFN, IFN-omega, was evaluated in both in vitro and in vivo studies of human cancer. For these studies, the cDNA for human IFN-omega was cloned into a eukaryotic expression plasmid DNA (pDNA) driven by the cytomegalovirus promoter. Supernatants from UM449 cells transfected in vitro with IFN-omega pDNA had antiproliferative effects on 11 of 13 human tumor cell lines. For in vivo studies, nude mice were implanted s.c. with one of the following human tumors: NIH: OVCAR-3 ovarian carcinoma, A375 melanoma, or A431 epidermoid carcinoma. Direct intratumoral injection of 100 microg of a IFN-omega pDNA DMRIE/DOPE complex (1:1 DNA:DMRIE mass ratio) for 6 consecutive days resulted in a significant reduction in the tumor volume of NIH: OVCAR-3 ovarian carcinoma or A375 melanoma (P = 0.02). IFN-omega pDNA delivered by i.m. injection also had an antitumor effect. Nude mice bearing s.c. A431 epidermoid carcinoma and injected i.m. with 100 microg of IFN-omega pDNA, twice per week for 3 weeks, had a significant reduction in tumor volume (P = 0.009). These results demonstrate for the first time that IFN-omega can have in vivo antitumor effects in several models of human cancer.
Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure.

Knowledge about the role of the right ventricle in health and disease historically has lagged behind that of the left ventricle. Less muscular, restricted in its role to pumping blood through a single organ, and less frequently or obviously involved than the left ventricle in diseases of epidemic proportions such as myocardial ischemia, cardiomyopathy, or valvulopathy, the right ventricle has generally been considered a mere bystander, a victim of pathological processes affecting the cardiovascular system. Consequently, comparatively little attention has been devoted to how right ventricular dysfunction may be best detected and measured, what specific molecular and cellular mechanisms contribute to maintenance or failure of normal right ventricular function, how right ventricular dysfunction evolves structurally and functionally, or what interventions might best preserve right ventricular function. Nevertheless, even the proportionately limited information related to right ventricular function, its impairment in various disease states, and its impact on the outcome of those diseases suggests that the right ventricle is an important contributor and that further understanding of these issues is of pivotal importance. For this reason, the National Heart, Lung, and Blood Institute convened a working group charged with delineating in broad terms the current base of scientific and medical understanding about the right ventricle and identifying avenues of investigation likely to meaningfully advance knowledge in a clinically useful direction. The following summary represents the presentations and discussions of this working group. The right ventricle is affected by and contributes to a number of disease processes, including perhaps most notably pulmonary hypertension caused by a variety of lung or pulmonary vascular diseases (cor pulmonale). Other diseases affect the right ventricle in different ways, including global, left ventricular–, or right ventricular–specific cardiomyopathy; right ventricular ischemia or infarction; pulmonary or tricuspid valvular heart disease; and left-to-right shunts. The right ventricle pumps the same …
Evaluation of Anti-nociceptive and Anti-inflammatory Activities of Novel Chalcone Derivatives

Chalcone (1,3-diarylprop-2-en-1-one) derivatives have been introduced as selective cyclooxygenase-2 inhibitors. In the present study, anti-nociceptive and anti-inflammatory effects of eight novel compounds were evaluated in male mice and Wistar rats by using the writhing and formalin-induced paw edema tests respectively. The activities of the compounds were compared with celecoxib as a reference drug. Then, novel compounds were divided into two regioisomeric groups based on the position of the methylsulfonyl substitution. Compounds with substituents such as: 1) H, 2) Me, 3) F and 4) Cl at para position of the phenyl ring of (E)-3-(4-Methanesulfonylphenyl)-1-phenylprop-2 en-1-one were selected in the first group. The regioisomer compounds with 5) H, 6) Me, 7) F and 8) OMe substitutions at C-4 of phenyl ring of (E)-1-(4-Methanesulfonylphenyl)-3-phenylprop-2-en-1-one were chosen as second group. All compounds showed dose-dependent anti-nociceptive activity in writhing test. Interestingly, the potency of anti-nociceptive effect of compounds 1, 2, 5 and 6 were significantly higher than celecoxib. The regioisomeric compounds 1 and 5 with high anti-nociceptive effects, showed a significant dose-dependent anti inflammatory activity in the paw edema test as well. The results showed that compounds with no substituent or small size substituents at para position of the phenyl ring are the most potent compound in writhing test. Our results revealed that the introduction of a bulky group such as methoxy or chlorine at the vicinal aromatic chain of the derivatives decreases the anti-inflammatory/ anti-nociceptive effects. The comparison of estimated ED50 of each pair of the regioisomeric compounds indicates that the relative position of SO2Me to carbonyl moiety did not affect the potency.
THE IMPACT OF COOPERATIVE LEARNING IN TEACHING COMMUNICATION SKILLS FOR PSYCHIATRIC NURSING STUDENTS

Effective communication has long been recognized as a corner stone and vital component of high-quality nursing care process starting from assessment till evaluation of care. It is necessary for nurses to be effective communicators, so that they can deliver safe and effective nursing practice. To be effective within a dynamic complex psychiatric care system and to help patients achieve positive outcomes, psychiatric nurses need to be proficient in communication skills as they are in clinical skills. Poor communication can lead to angry feelings, omission or distortion of important information, and subsequently deleterious effects on patients' outcomes. Professional nursing education aims to produce quality nursing graduates who can respond to demands of the changing healthcare environment. Cooperative learning (CL) is one of the learning methods that have social well as academic benefits. It lowers the students' anxiety; promote students responsibility for their own learning, and improves interpersonal skills and higher level thinking ability. Researches found that cooperative learning results in higher achievement, more positive relationships among students, and greater psychological adjustment. Application of cooperative learning will prepare psychiatric nursing students to able to work cooperatively with patients as well as with other psychiatric team members. This paper provides a brief overview of the literature on the impact of cooperative learning in teaching communication skills for psychiatric nursing students. It could be said that CL is helpful in developing student nurses ability to practice communication skills effectively and successfully with psychotic patients.
Passive velocity field control of a redundant cable-driven robot with tension limitations

This paper proposes a novel dynamic control approach for a cable driven robot with high redundant actuation and cable tension limitations to perform tracking task while interacting with environment. In order for a cable-driven exoskeleton robot to execute the task smoothly and safely, it is necessary to consider the tracking motion performance as well as passivity when interacting with the environment under the conditions of the actuation cables' redundancy and the pulling limitation. With the additional consideration of the maximum limitation of the cable tension, cable-driven robot actually can only apply a certain range of feasible wrench on the external environment, which makes the task executed by robot be restricted. In order to make designed wrench be feasible and keep the desired trajectory tracking ability, we present a new control method by extending passive velocity field control (PVFC) method considering tracking stability and passivity. The approach augmented a higher dimensional virtual flywheel dynamics in a specific orthogonal complement space of the cable's actuation space. After the final adjustment of the designed wrench with respect to the cable's constraint, this method is capable of driving the cable robot to complete the trajectory tracking task and realize the passivity.
Selective Targeting of Interferon γ to Stromal Fibroblasts and Pericytes as a Novel Therapeutic Approach to Inhibit Angiogenesis and Tumor Growth

New approaches to block the function of tumor stromal cells such as cancer-associated fibroblasts and pericytes is an emerging field in cancer therapeutics as these cells play a crucial role in promoting angiogenesis and tumor growth via paracrine signals. Because of immunomodulatory and other antitumor activities, IFNγ, a pleiotropic cytokine, has been used as an anticancer agent in clinical trials. Unfortunately only modest beneficial effects, but severe side effects, were seen. In this study, we delivered IFNγ to stromal fibroblasts and pericytes, considering its direct antifibrotic activity, using our platelet-derived growth factor-beta receptor (PDGFβR)-binding carrier (pPB-HSA), as these cells abundantly express PDGFβR. We chemically conjugated IFNγ to pPB-HSA using a heterobifunctional PEG linker. In vitro in NIH3T3 fibroblasts, pPB-HSA-IFNγ conjugate activated IFNγ-signaling (pSTAT1α) and inhibited their activation and migration. Furthermore, pPB-HSA-IFNγ inhibited fibroblasts-induced tube formation of H5V endothelial cells. In vivo in B16 tumor-bearing mice, pPB-HSA-IFNγ rapidly accumulated in tumor stroma and pericytes and significantly inhibited the tumor growth while untargeted IFNγ and pPB-HSA carrier were ineffective. These antitumor effects of pPB-HSA-IFNγ were attributed to the inhibition of tumor vascularization, as shown with α-SMA and CD-31 staining. Moreover, pPB-HSA-IFNγ induced MHC-II expression specifically in tumors compared with untargeted IFNγ, indicating the specificity of this approach. This study thus shows the impact of drug targeting to tumor stromal cells in cancer therapy as well as provides new opportunities to use cytokines for therapeutic application. Mol Cancer Ther; 11(11); 2419–28. ©2012 AACR.
The Direct and Indirect Effects of Advertising Spending on Firm Value

Marketing decision makers are increasingly aware of the importance of shareholder value maximization, which calls for an evaluation of the long-term effects of their actions on product-market response and investor response. However, the marketing literature to date has focused on the sales or profit response of marketing actions, and the goals of marketing have traditionally been formulated from a customer perspective. Recently, there have been a few studies of the long-term investor response to marketing actions. The current research investigates one important aspect of this impact, the long-term relationship between advertising spending and market capitalization. The authors hypothesize that advertising can have a direct effect on valuation (i.e., an effect beyond its indirect effect through sales revenue and profit response). The empirical results across two industries provide support for the hypothesis that advertising spending has a positive, long-term impact on own firms’ market capitalization and may have a negative impact on the valuation of a competitor of comparable size. The authors quantify the magnitude of this investor response effect for and discuss its implications for further research.
Molecular mechanisms of general anesthesia

General anesthetics produce a widespread neurodepression in the central nervous system by enhancing inhibitory neurotransmission and reducing excitatory neurotransmission. However, the action mechanisms of general anesthetics are not completely understood. Moreover, the general anesthetic state comprises multiple components (amnesia, unconsciousness, analgesia, and immobility), each of which is mediated by different receptors and neuronal pathways. Recently, neurotransmitter- and voltage-gated ion channels have emerged as the most likely molecular targets for general anesthetics. The γ-aminobutyric acid type A (GABAA) receptors are leading candidates as a primary target of general anesthetics. This review summarizes current knowledge on how anesthetics modify GABAA receptor function.
Joint Graph Decomposition and Node Labeling by Local Search

We state a combinatorial optimization problem whose feasible solutions define both a decomposition and a node labeling of a given graph. This problem offers a common mathematical abstraction of seemingly unrelated computer vision tasks, including instance-separating semantic segmentation, articulated human body pose estimation and multiple object tracking. Conceptually, the problem we propose generalizes the unconstrained integer quadratic program and the minimum cost lifted multicut problem, both of which are NP-hard. In order to find feasible solutions efficiently, we define a local search algorithm that converges monotonously to a local optimum, offering a feasible solution at any time. To demonstrate the effectiveness of this algorithm in solving computer vision tasks, we report running times and competitive solutions for two above-mentioned applications.
Topology of generic line arrangements

Our aim is to generalize the result that two generic complex line arrangements are equivalent. In fact for a line arrangement A we associate its defining polynomial, the product of a_ix+b_iy+c_i, so that A = (f=0). We prove that the defining polynomials of two generic line arrangements are, up to a small deformation, topologically equivalent. In higher dimension the related result is that within a family of equivalent hyperplane arrangements the defining polynomials are topologically equivalent.
Quantum Mechanics as Quantum Information (and only a little more)

In this paper, I try once again to cause some good-natured trouble. The issue remains, when will we ever stop burdening the taxpayer with conferences devoted to the quantum foundations? The suspicion is expressed that no end will be in sight until a means is found to reduce quantum theory to two or three statements of crisp physical (rather than abstract, axiomatic) significance. In this regard, no tool appears better calibrated for a direct assault than quantum information theory. Far from a strained application of the latest fad to a time-honored problem, this method holds promise precisely because a large part--but not all--of the structure of quantum theory has always concerned information. It is just that the physics community needs reminding. This paper, though taking quant-ph/0106166 as its core, corrects one mistake and offers several observations beyond the previous version. In particular, I identify one element of quantum mechanics that I would not label a subjective term in the theory--it is the integer parameter D traditionally ascribed to a quantum system via its Hilbert-space dimension.