Miracle-dz/UniFAR-FTUs huggingface dataset:
On the construction of Q-controllable graphs

A connected graph is called Q-controllable if its signless Laplacian eigenvalues are mutually distinct and main. Two graphs G and H are said to be Q-cospectral if they share the same signless Laplacian spectrum. In this paper, infinite families of Q-controllable graphs are constructed, by using the operator of rooted product introduced by Godsil and McKay. In the process, innitely many non-isomorphic Q-cospectral graphs are also constructed, especially, including those graphs whose signless Laplacian eigenvalues are mutually distinct.
Cities and Regions as Self-Organizing Systems: Models of Complexity

1. Inter-Urban Evolution 2. Dynamic Models of Urban Growth 3. The Changing Pattern of Settlement of the USA 4. The Spatial Evolution of Jobs and People in Belgium 5. The Senegal Model 6. Intra-Urban Evolution 7. Towards a Science of Complex Systems 8. Policy Exploration and Decision Support for Sustainable Development 9. Case Studies and Further Developments
A new generation of universal contactless Battery Charging platform for portable Consumer Electronic equipment

This invention is related to a new planar inductive battery charger for portable electronic equipment such as mobile phones, palm pilots and CD players. New multilayer printed-circuit-board winding matrices of hexagonal structures that can generate magnetic flux of almost even magnitude over the surface of the winding arrays have been developed. The new concept forms the basis for a new generation of universal charging platform for a wide range of portable electronic equipment. Different types of portable electronic equipment can be placed and charged simultaneously on the charging platform, regardless of their positions and orientation. The principle and structure of the charging platform are explained and the feasibility has been confirmed with practical measurements. The proposed universal charging platform has been successfully used for mobile phones, MP3 players and electronic dictionaries.
Down‐Regulated Long Non‐Coding RNA MEG3 and its Effect on Promoting Apoptosis and Suppressing Migration of Trophoblast Cells

Preeclampsia is characterized by hypertension and proteinuria twenty weeks into pregnancy. Failure of uterine spiral artery remodeling contributes to preeclampsia's development. The development might be associated with trophoblast cells functioning abnormally. Long non‐coding RNAs (lncRNAs) are aberrantly expressed in many diseases. Maternally expressed gene 3 (MEG3), one of these lncRNAs, might function as a tumor suppressor. Aberrant expression of MEG3 induces prenatal death, and little is known of MEG3's role in preeclampsia. This study aims to identify the role of lncRNA MEG3 on apoptosis and the migration of human trophoblast cells, and to investigate the involvement of lncRNA MEG3 in pathogenic mechanisms underlying preeclampsia. In this study, we found MEG3 levels were down‐regulated by approximately 80% in placental samples collected from preeclamptic patients (n = 30) compared to samples collected from normotensive patients (n = 30) by qRT‐PCR analysis. By designing RNA interference species to suppress MEG3 and specific plasmids designed to over‐express MEG3, we explored the role of MEG3 on the functions of two trophoblast cell‐lines, HTR‐8/SVneo and JEG3 cells. Over‐expression of MEG3 reduced apoptosis and promoted migration of HTR‐8/SVneo and JEG3 cells. Furthermore, inhibition of endogenous MEG3 increased apoptosis and decreased migration of HTR‐8/SVneo and JEG3 cells. Additionally, lncRNA MEG3 influenced expression of NF‐κB, Caspase‐3, and Bax protein expressions in trophoblast cells. Our findings highlight that abnormal levels of lncRNA MEG3 might lead to aberrant conditions in HTR‐8/SVneo and JEG3 trophoblast cells, which might be associated with uterine spiral artery remodeling failure and its contribution to preeclampsia. J. Cell. Biochem. 116: 542–550, 2015. © 2014 Wiley Periodicals, Inc.
Mining version histories to verify the learning process of Legitimate Peripheral Participants

Since code revisions reflect the extent of human involvement in the software development process, revision histories reveal the interactions and interfaces between developers and modules.We therefore divide developers and modules into groups according to the revision histories of the open source software repository, for example, sourceforge.net. To describe the interactions in the open source development process, we use a representative model, Legitimate Peripheral Participation (LPP) [6], to divide developers into groups such as core and peripheral teams, based on the evolutionary process of learning behavior.With the conventional module relationship, we divide modules into kernel and non-kernel types (such as UI). In the past, groups of developers and modules have been partitioned naturally with informal criteria. In this work, however, we propose a developer-module relationship model to analyze the grouping structures between developers and modules. Our results show some process cases of relative importance on the constructed graph of project development. The graph reveals certain subtle relationships in the interactions between core and non-core team developers, and the interfaces between kernel and non-kernel modules.
Hyperparameters Evidence and Generalisation for an Unrealisable Rule

Using a statistical mechanical formalism we calculate the evidence, generalisation error and consistency measure for a linear perceptron trained and tested on a set of examples generated by a non linear teacher. The teacher is said to be unrealisable because the student can never model it without error. Our model allows us to interpolate between the known case of a linear teacher, and an unrealisable, nonlinear teacher. A comparison of the hyperparameters which maximise the evidence with those that optimise the performance measures reveals that, in the non-linear case, the evidence procedure is a misleading guide to optimising performance. Finally, we explore the extent to which the evidence procedure is unreliable and find that, despite being sub-optimal, in some circumstances it might be a useful method for fixing the hyperparameters.
Tracking the Martian Mantle Signature in Olivine-Hosted Melt Inclusions of Basaltic Shergottites Yamato 980459 and Tissint

The Martian shergottite meteorites are basaltic to lherzolitic igneous rocks that represent a period of relatively young mantle melting and volcanism, approximately 600-150 Ma (e.g. [1,2]). Their isotopic and elemental composition has provided important constraints on the accretion, evolution, structure and bulk composition of Mars. Measurements of the radiogenic isotope and trace element concentrations of the shergottite meteorite suite have identified two end-members; (1) incompatible trace element enriched, with radiogenic Sr and negative epsilon Nd-143, and (2) incompatible traceelement depleted, with non-radiogenic Sr and positive epsilon 143-Nd(e.g. [3-5]). The depleted component represents the shergottite martian mantle. The identity of the enriched component is subject to debate, and has been proposed to be either assimilated ancient martian crust [3] or from enriched domains in the martian mantle that may represent a late-stage magma ocean crystallization residue [4,5]. Olivine-phyric shergottites typically have the highest Mg# of the shergottite group and represent near-primitive melts having experienced minimal fractional crystallization or crystal accumulation [6]. Olivine-hosted melt inclusions (MI) in these shergottites represent the most chemically primitive components available to understand the nature of their source(s), melting processes in the martian mantle, and origin of enriched components. We present trace element compositions of olivine hosted melt inclusions in two depleted olivinephyric shergottites, Yamato 980459 (Y98) and Tissint (Fig. 1), and the mesostasis glass of Y98, using Secondary Ionization Mass Spectrometry (SIMS). We discuss our data in the context of understanding the nature and origin of the depleted martian mantle and the emergence of the enriched component.
Intra‐Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof‐of‐Concept Clinical Trial

Mesenchymal stem cells (MSCs) are known to have a potential for articular cartilage regeneration. However, most studies focused on focal cartilage defect through surgical implantation. For the treatment of generalized cartilage loss in osteoarthritis, an alternative delivery strategy would be more appropriate. The purpose of this study was to assess the safety and efficacy of intra‐articular injection of autologous adipose tissue derived MSCs (AD‐MSCs) for knee osteoarthritis. We enrolled 18 patients with osteoarthritis of the knee and injected AD MSCs into the knee. The phase I study consists of three dose‐escalation cohorts; the low‐dose (1.0 × 107 cells), mid‐dose (5.0 × 107), and high‐dose (1.0 × 108) group with three patients each. The phase II included nine patients receiving the high‐dose. The primary outcomes were the safety and the Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) at 6 months. Secondary outcomes included clinical, radiological, arthroscopic, and histological evaluations. There was no treatment‐related adverse event. The WOMAC score improved at 6 months after injection in the high‐dose group. The size of cartilage defect decreased while the volume of cartilage increased in the medial femoral and tibial condyles of the high‐dose group. Arthroscopy showed that the size of cartilage defect decreased in the medial femoral and medial tibial condyles of the high‐dose group. Histology demonstrated thick, hyaline‐like cartilage regeneration. These results showed that intra‐articular injection of 1.0 × 108 AD MSCs into the osteoarthritic knee improved function and pain of the knee joint without causing adverse events, and reduced cartilage defects by regeneration of hyaline‐like articular cartilage. Stem Cells 2014;32:1254–1266
Physical activity and lung cancer risk in male smokers

We examined the association between physical activity and lung cancer in a prospective cohort of 27,087 male smokers, ages 50–69 years, enrolled in the Alpha‐Tocopherol, Beta Carotene Cancer Prevention (ATBC) Study. After an average of 10 years of follow‐up, 1,442 lung cancer cases were diagnosed. Cox proportional hazards models were used to estimate the relative risk (RR) and 95% confidence intervals (CI) of lung cancer associated with self‐reported occupational and leisure‐time activity, adjusted for age, supplement group, body mass index, cigarettes smoked daily, years of smoking, education, energy intake and vegetable intake. There were no associations between occupational, leisure‐time or combined categories of physical activity with lung cancer risk; however, age appeared to modify the effect of leisure‐time activity (p = 0.02). Within increasing quartiles of age, the RRs (CI) for men active in leisure time compared to sedentary men were 0.77 (0.54–1.09), 0.74 (0.57–0.95), 1.09 (0.89–1.33) and 1.03 (0.88–1.21). These data suggest that among smokers, neither occupational nor leisure‐time activity is associated with lung cancer risk. There may, however, be some modest risk reduction associated with leisure activity among younger smokers. Published 2002 Wiley‐Liss, Inc.
YTH domain family 2 orchestrates epithelial-mesenchymal transition/proliferation dichotomy in pancreatic cancer cells

ABSTRACT Recent studies show that YTH domain family 2 (YTHDF2) preferentially binds to m6A-containing mRNA regulates localization and stability of the bound mRNA. However, the role of YTHDF2 in pancreatic cancers remains to be elucidated. Here, we find that YTHDF2 expression is up-regulated in pancreatic cancer tissues compared with normal tissues at both mRNA and protein levels, and is higher in clinical patients with later stages of pancreatic cancer, indicating that YTHDF2 possesses potential clinical significance for diagnosis and prognosis of pancreatic cancers. Furthermore, we find that YTHDF2 orchestrates two cellular processes: promotes proliferation and inhibits migration and invasion in pancreatic cancer cells, a phenomenon called “migration-proliferation dichotomy”, as well as epithelial-mesenchymal transition (EMT) in pancreatic cancer cells. Furthermore, YTHDF2 knockdown significantly increases the total YAP expression, but inhibits TGF-β/Smad signaling, indicating that YTHDF2 regulates EMT probably via YAP signaling. In summary, all these findings suggest that YTHDF2 may be a new predictive biomarker of development of pancreatic cancer, but a serious consideration is needed to treat YTHDF2 as a target for pancreatic cancer.
Laparoscopic coagulation of the uterine blood supply in laparoscopic-assisted vaginal hysterectomy is associated with less blood loss.

BACKGROUND Does laparoscopic coagulation of the uterine blood supply decrease blood loss compared with transvaginal ligature of the uterine vessels? METHODS Intra- and postoperative data of 446 patients undergoing laparoscopic-assisted vaginal hysterectomy at the Department of Gynecology, University of Jena, between 1998 and 2001 were analysed. In 213 patients the uterine blood supply was transected laparoscopically at the origin of the uterine vessels (LAVH type II) and in 233 patients (LAVH type I) transvaginally. RESULTS Patients in both groups were comparable with respect to median age, Quetelet index, and parity. The drop of hemoglobin between the preoperative day and postoperative day 3 was 0.8 mmol/l or 0.6 mmol/l for LAVH type I without or with BSO vs 0.3 mmol/l or 0.4 mmol/l for LAVH type II without or with BSO (p = 0.001), respectively. Median operative time was similar for both techniques: LAVH type I 136 min or with BSO 128 min vs LAVH type II 126 min or with BSO 131 min. The weight of the removed uteri was significantly lower in LAVH type I vs type II (220 vs 270 grams), but similar when LAVH was combined with BSO (160 vs 178 grams). The rate of intraoperative complications was 2.2% vs 0.9% between LAVH type I or II (n.s.), but 9% vs 3.3% for overall postoperative complications (p = 0.01). CONCLUSIONS Laparoscopic coagulation of the uterine blood supply at the origin of uterine vessels is a safe technique which minimizes blood loss in LAVH. In patients with a low preoperative hemoglobin value this technique is indicated.
Computer Forensic Text Analysis with Open Source Software

Detta papper koncentrerar sig pa kriminaltekniska undersokningar av text, med fokus pa anvandande av mjukvara med oppen kallkod. Pappret diskuterar och undersoker olika tekniker for framtida automatisering av dessa undersokningar.
An optimal memory allocation for application-specific multiprocessor system-on-chip

We present a novel and systematic approach for the design of shared memory architectures in the case of application-specific multiprocessor system-on-chip. This paper focuses on a memory allocation step which is based on an integer linear programming model. It permits one to obtain an optimal distributed shared memory architecture minimizing the global cost to access the shared data in the application, and the memory cost. Our approach allows automatic generation of an architecture-level specification of the application. The effectiveness of this approach is illustrated by a packet routing switch example.
Reconstructing Head Waves With Virtual Source Method

The original applications of the Virtual Source Method (VSM) concentrate on imaging and monitoring through complex and changing overburden. This can be accomplished by correlating the wavefields recorded by downhole geophones. There are a number of reasons to expect even better results when this concept is extended to using head waves for reservoir imaging and monitoring purposes. The current practice to create virtual source data is to correlate the gated direct arrival at virtual source with total wavefield at receivers. Using a simple acoustic 2D model with two half-spaces having different velocities, we demonstrate the usefulness of correlating the head waves with different types of waves, theoretically and numerically.
A Robust Convex Formulation for Ensemble Clustering

We formulate ensemble clustering as a regularization problem over nuclear norm and cluster-wise group norm, and present an efficient optimization algorithm, which we call Robust Convex Ensemble Clustering (RCEC). A key feature of RCEC allows to remove anomalous cluster assignments obtained from component clustering methods by using the group-norm regularization. Moreover, the proposed method is convex and can find the globally optimal solution. We first showed that using synthetic data experiments, RCEC could learn stable cluster assignments from the input matrix including anomalous clusters. We then showed that RCEC outperformed state-of-the-art ensemble clustering methods by using real-world data sets.
Caveolae: From Cell Biology to Animal Physiology

Among the membrane compartments of a cell, vesicles known as “caveolae” have long defied functional characterization. However, since the identification of a family of proteins termed “caveolins”, that form and reside in caveolae, a better understanding has emerged. It is now clear that caveolae do not merely play a singular role in the cell, but are pleiotropic in nature—serving to modulate many cellular functions. The purpose of this review is to explicate what is known about caveolins/caveolae and highlight growing areas of caveolar research.
Constructing a Personality-Annotated Corpus for Educational Game based on Leary's Rose Framework

Researchers have recognized the importance of classifying personality through discourse for many years. However, this line of research tends to focus almost exclusively on the personality categories known as the Big Five factors. Though this information is certainly valuable, it may also be useful to categorize personality based on the Leary’s Inter- personal Circumplex model which emphasizes a predictive function. In this paper we construct the data set for personality annotation among six dimensions (based on a coding scheme developed from Leary’s Interpersonal Circumplex) for players using a chat interaction in an epistemic game, Land Science. Our results indicate that overall personality annotation is reliable (Average Kappa = 0.65) with the highest reliability for the competitive dimension and the lowest reliability for the leading dimension.
The C-terminal half of the anti-sigma factor FlgM contains a dynamic equilibrium solution structure favoring helical conformations.

FlgM is the inhibitor of sigma 28, a transcription factor specific for the expression of bacterial flagella and chemotaxis genes. FlgM is also exported from the cytoplasm to the outside of the cell during the process of flagella filament assembly. In the absence of its targets, FlgM is a dynamic, mostly unfolded, molecule [Daughdrill, G. W. , et al. (1997) Nat. Struct. Biol. 4(4), 285-291]. The NMR resonance assignments, dynamics, and average secondary structure of this mostly unfolded form of FlgM are reported here. Because of the dynamic behavior of FlgM, the deviation of C alpha chemical shifts from the random coil values was used to test for the presence of secondary structure [Wishart, D. S. , and Sykes, B. D. (1994) Methods Enzymol. 239, 363-392]. This analysis shows two contiguous regions in the C-terminal half of FlgM with helical C alpha chemical shifts. These two regions, M60-G73 and A83-A90, contained less than 10 medium-range NOEs, and the 15N relaxation parameters suggest the helical structure is not rigid. However, the C alpha chemical shifts of M60-G73, A83-A90, and other residues in the C-terminal half of FlgM shift toward their canonical random coil values with the addition of a chemical denaturant. Along with the values of the order parameter, S2, this observation suggests the C-terminal half of FlgM exists in an equilibrium structural state that is nonrandom. The same analysis of the N-terminal half of FlgM suggests it more closely resembles a random coil in conditions with and without denaturant. It appears the C-terminal half of FlgM lacks sufficient intramolecular contacts to form stable secondary or tertiary structures. It is known this C-terminal region becomes rigidly held when FlgM binds sigma 28 (Daughdrill et al., 1997), and it is possible that binding stabilizes the helical structure. The potential evolutionary relationship between the inhibitory interaction of FlgM with sigma 28 and the autoinhibition observed in sigma 70 is discussed.
Studies on the hypoglycaemic activity of Punica granatum seed in streptozotocin induced diabetic rats

The hypoglycaemic activity of Punica granatum Linn. (Family Punicaceae) seed extract on rats made diabetic by streptozotocin (STZ) was investigated. The methanol extract of the seed at doses of 300 and 600 mg/kg, and chlorpropamide 200 mg/kg was administered to STZ diabetic rats. The seed extract (150, 300 and 600 mg/kg, orally) caused a significant reduction of blood glucose levels in STZ induced diabetic rats by 47% and 52%, respectively, at the end of 12 h. Copyright © 2001 John Wiley & Sons, Ltd.
LA SEQUÍA: DE RIESGO NATURAL A INDUCIDO. EL EJEMPLO DE LA CUENCA DEL RÍO SEGURA

The interaction society-nature gives himself inside a few very changeable limits. Without exceeding the threshold of drought, the technical and social mechanisms allow certain accommodation on the territory, attenuating the effects of the water shortage. Nevertheless, when the threshold is exceeded the forms of adjustment are insuffi cient, and from it will derive socioeconomic negative effects and political confl icts, as the originated ones during the last period of drought.
Eurographics -ieee Vgtc Symposium on Visualization (2005) Galilean Invariant Extraction and Iconic Representation of Vortex Core Lines

While vortex region quantities are Galilean invariant, most methods for extracting vortex cores depend on the frame of reference. We present an approach to extracting vortex core lines independently of the frame of reference by extracting ridge and valley lines of Galilean invariant vortex region quantities. We discuss a generalization of this concept leading to higher dimensional features. For the visualization of extracted line features we use an iconic representation indicating their scale and extent. We apply our approach to datasets from numerical simulations and experimental measurements.
Attribution of observed historical near‒surface temperature variations to anthropogenic and natural causes using CMIP5 simulations

We have carried out an investigation into the causes of changes in near‒surface temperatures from 1860 to 2010. We analyze the HadCRUT4 observational data set which has the most comprehensive set of adjustments available to date for systematic biases in sea surface temperatures and the CMIP5 ensemble of coupled models which represents the most sophisticated multi‒model climate modeling exercise yet carried out. Simulations that incorporate both anthropogenic and natural factors span changes in observed temperatures between 1860 and 2010, while simulations of natural factors do not warm as much as observed. As a result of sampling a much wider range of structural modeling uncertainty, we find a wider spread of historic temperature changes in CMIP5 than was simulated by the previous multi‒model ensemble, CMIP3. However, calculations of attributable temperature trends based on optimal detection support previous conclusions that human‒induced greenhouse gases dominate observed global warming since the mid‒20th century. With a much wider exploration of model uncertainty than previously carried out, we find that individually the models give a wide range of possible counteracting cooling from the direct and indirect effects of aerosols and other non‒greenhouse gas anthropogenic forcings. Analyzing the multi‒model mean over 1951–2010 (focusing on the most robust result), we estimate a range of possible contributions to the observed warming of approximately 0.6 K from greenhouse gases of between 0.6 and 1.2 K, balanced by a counteracting cooling from other anthropogenic forcings of between 0 and −0.5 K.