Miracle-dz/UniFAR-FTUs huggingface dataset:
Venture capital dynamics, the public sector and the high technology industry

The high technology (hi-tech) sector has become an important factor for economic growth in many countries. Israel is an extreme case where most of the production of the hi-tech sector is exported, and moreover, comprises more than half of its industrial exports. In this study, we focused on the optimal funding of the public sector for the hi-tech industry in the presence of short-term, cyclical, venture capital funding. We addressed the first issue by constructing a decision-making model that results in the optimal governmental support for the hi-tech sector. For the latter issue, we constructed a model that accounts for the dynamics of the venture capital (VC) industry over 1995-2005. Our findings indicate that the VC industry is highly correlated with the NASDAQ composite stock index and that it is a supply-driven market. The optimal public sector's policy for funding the hi-tech sector should be anti-cyclical, dynamic and conditioned on the VC investments as well as on the specific sector that is supported. The models and their validation against empirical data are presented and discussed as well as the practical implications for policy and decision-makers.
Embryonic myogenesis pathways in muscle regeneration

Embryonic myogenesis involves the staged induction of myogenic regulatory factors and positional cues that dictate cell determination, proliferation, and differentiation into adult muscle. Muscle is able to regenerate after damage, and muscle regeneration is generally thought to recapitulate myogenesis during embryogenesis. There has been considerable progress in the delineation of myogenesis pathways during embryogenesis, but it is not known whether the same signaling pathways are relevant to muscle regeneration in adults. Here, we defined the subset of embryogenesis pathways induced in muscle regeneration using a 27 time‐point in vivo muscle regeneration series. The embryonic Wnt (Wnt1, 3a, 7a, 11), Shh pathway, and the BMP (BMP2, 4, 7) pathway were not induced during muscle regeneration. Moreover, antagonists of Wnt signaling, sFRP1, sFRP2, and sFRP4 (secreted frizzled‐related proteins) were significantly up‐regulated, suggesting active inhibition of the Wnt pathway. The pro‐differentiation FGFR4 pathway was transiently expressed at day 3, commensurate with expression of MyoD, Myogenin, Myf5, and Pax7. Protein verification studies showed fibroblast growth factor receptor 4 (FGFR4) protein to be strongly expressed in differentiating myoblasts and newly formed myotubes. We present evidence that FGF6 is likely the key ligand for FGFR4 during muscle regeneration, and further suggest that FGF6 is released from necrotic myofibers where it is then sequestered by basal laminae. We also confirmed activation of Notch1 in the regenerating muscle. Finally, known MyoD coactivators (MEF2A, p/CIP, TCF12) and repressors (Twist, Id2) were strongly induced at appropriate time points. Taken together, our results suggest that embryonic positional signals (Wnt, Shh, and BMP) are not induced in postnatal muscle regeneration, whereas cell‐autonomous factors (Pax7, MRFs, FGFR4) involving muscle precursor proliferation and differentiation are recapitulated by muscle regeneration. Developmental Dynamics 229:380–392, 2004. © 2004 Wiley‐Liss, Inc.
Differential Evolution-Based Parameter Tuning in Model-Free Adaptive Control

We introduce a stochastic optimization algorithm, a variation of Opposition-based Multi-objective Differential Evolution with replacement of current population by random individuals in specifics periods, to tune parameters of a Model-Free Adaptive Control System. It is often hard to set such parameters and they are selected according to qualitative analysis of the system response. Evolutionary Algorithms with a single objective function have been used to set the parameters of controllers. Hence, a multi-objective approach was used to solve this problem in order to optimize more than one performance index. In this study, we propose two objective functions in order to approximate the functions of the desired output and the system response. The simulation results suggest the effectiveness of the method to determine the parameters of the controller.
A conceptual model for the development of service innovation capabilities in Research and Technology Organisations

As services dominate developed economies all over the world, service innovation represents an important challenge for organisations wanting to ensure their successful performance over time. In this paper, we propose a conceptual model for the development of service innovation capabilities within a special type of service-intensive organisation: Research and Technology Organisations (RTOs), which are important innovation actors in contemporary economies. This model focuses on the interplay between resources and processes, and highlights the importance of service innovation strategies for developing relevant capabilities. Finally, "dynamisation" perspectives that ensure the sustainability of these capabilities are also presented. Reference to this paper should be made as follows: Giannopoulou, E. , Gryszkiewicz, L. and Barlatier, P-J. (2011) 'A conceptual model for the development of service innovation capabilities in Research and Technology organisations', Int. J. Knowledge Management Studies, Vol. 4, No. 4, pp.319-335.
Who gets the job? Recruitment and selection at a ‘second-generation’ Japanese automotive components transplant in the US

Literature on Japanese transplant manufacturing firms in the automotive sector often emphasise the importance placed on attitude as opposed to skills in the hiring decisions for line workers. In this paper, a case study of one second-tier components supplier for a major Japanese automotive assembler in the Midwestern United States provides the opinions of senior managers and human resource associates regarding recruitment and selection practices. In-depth interviews, carried out over a two-week period in August 2000, are used to develop an understanding of the recruitment and selection process for line workers as well as to investigate the desired skills and value of previous Japanese experience. Results of the case study analysis are compared with two models from the literature: (1) a model of recruitment and selection at Japanese automotive-related firms in Japan and (2) a model of recruitment and selection at Japanese transplant automotive-related firms abroad. Deviations from the two models point not to a new paradigm of ‘second-generation’ Japanese transplants – those that have moved into regions quite familiar with Japanese firms and related management and production methods – but rather to overall weaknesses in the stereotypical models. Managerial opinions within the case study firm place limited value on familiarity with a Japanese environment, considering such experience secondary to attitudes and work ethics that are in line with the philosophy of the case study firm.
A Class of Binary Locally Repairable Codes

An (n, k) erasure code that can recover any coded symbol by at most r other coded symbols is called a locally repairable code (LRC) with locality r. LRCs have been recently implemented in distributed storage systems. Coding complexity reduction can be significantly decreased by using binary LRCs (BLRCs) as they eliminate costly multiplication calculation. In this paper, motivated by the recently erasure codes with d = 4 used in practice, we propose BLRCs when (r + 1) | n and d = 4. We prove that our proposed binary codes are optimal for r ∈ {1, 3}, meaning that neither their locality nor their minimum distance can be improved by non-binary codes. For r ≥ 4, our proposed binary codes offer near-optimal code rate, with a rate gap of O(log r/n) compared with optimal nonbinary codes. While keeping the bulk of code structure binary, we eliminate this rate gap by using fields with sizes as small as r + 2 for only two redundant symbols. These non-binary codes still eliminate the need for costly multiplications in many operations including a single failure repair (a dominant repair scenario). Using the construction of spanning BLRC with d = 4 as a backbone, we also construct LRCs with minimum distance d ≥ 6. Furthermore, we obtain a closed-form equation for the mean-time to data-loss of arbitrary erasure codes.
Effects of Overexpression of Copper-Zinc and Manganese Superoxide Dismutases, Catalase, and Thioredoxin Reductase Genes on Longevity in Drosophila melanogaster*

The overexpression of antioxidative enzymes such as CuZn-superoxide dismutase (SOD), Mn-SOD, and catalase has previously been reported to extend life span in transgenic flies (Drosophila melanogaster). The purpose of this study was to determine whether life-extending effects persist if the recipient control strains of flies are relatively long-lived. Accordingly, the life spans of large numbers of replicate control and overexpressor lines were determined in two long-lived genetic backgrounds involving a combined total of >90,000 flies. Significant increases in the activities of both CuZn-SOD and catalase had no beneficial effect on survivorship in relatively long-lived y w mutant flies and were associated with slightly decreased life spans in wild type flies of the Oregon-R strain. The introduction of additional transgenes encoding Mn-SOD or thioredoxin reductase in the same genetic background also failed to cause life span extension. In conjunction with data from earlier studies, the results show that increasing the activities of these major antioxidative enzymes above wild type levels does not decrease the rate of aging in long-lived strains of Drosophila, although there may be some effect in relatively short-lived strains.
Modeling of a Time-Spreading OCDMA System Including Nonperfect Time Gating, Optical Thresholding, and Fully Asynchronous Signal/Interference Overlapping

We present an extended theoretical model for time-spreading optical code-division multiple-access (OCDMA) coherent systems. We have updated well-known model to evaluate multiuser interference to include arbitrary encoded/decoded chip shape, receiver transfer function, and optical thresholding before detection. Full asynchronous regime is also assumed to exploit statistical benefits over the dominant primary beat noise. The model provides clear improvements in terms of number of users and required intercodes crosstalk, leading to more feasible OCDMA systems.
The Strategy Process

Introduction. I. STRATEGY. 1. The Strategy Concept. Strategies for Change, Quinn. Five Ps for Strategy, Mintzberg. 2. The Strategist. The Manager's Job: Folklore and Fact, Mintzberg. Good Managers Don't Make Policy Decisions, Wrapp. 3. Strategy Design and Planning. The Concept of Corporate Strategy, Andrews. The Evaluation of Business Strategy, Rumelt. 4. Business Level Strategy Analysis. How Competitive Forces Shape Strategy, Porter. Generic Strategies for Locating and Distinguishing the Core Business, Mintzberg. 5. Strategy Formation. The Honda Effect, Pascale. Crafting Strategy, Mintzberg. Managing Strategy Formation: Logical Incrementalism, Quinn and Voyer. II. FOUNDATIONS OF STRATEGY FORMATION. 6. Structure and Systems. The 7-S Framework, Robert H. Waterman, Jr., Thomas J. Peters, and Julian R. Phillips. Structures, Forces and Forms in Effective Organizations, Mintzberg. 7. Organizational Culture and Strategy. Ideology and the Missionary Organization, Mintzberg. Organizational Culture: "Getting a Fix" on an Elusive Concept, W. Jack Duncan. 8. Power and Politics. The Institutional Function of Management, Jeffrey Pfeffer. Who Should Control the Corporation? , Mintzberg. III. STRATEGY PROCESSES IN CONTEXT. 9. Structure and Strategy in Entrepreneurial Organizations. The Entrepreneurial Organization, Mintzberg. Competitive Strategy in Emerging Industries, Michael E. Porter. Competitive Strategy in Fragmented Industries, Michael E. Porter. A Reexamination of the Niche Concept, Arnold C. Cooper, Gary E. Willard, Carolyn Y. Woo. 10. Structure and Strategy in Mature Organizations. The Machine Organization, Mintzberg. The Transition to Industry Maturity, Porter. 11. Structure and Strategy in Professional and Innovative Organizations. The Professional Organization, Mintzberg. The Innovative Organization, Mintzberg. Managing Innovation: Controlled Chaos, Quinn. 12. Corporate-Level Strategy and Structure. Generic Strategies for Elaborating, Extending and Reconceiving the Core Business, Mintzberg. The Diversified Organization, Mintzberg. From Competitive Advantage to Corporate Strategy, Porter. 13. Global Strategy and Structure. Global Strategy . In a World of Nations? , George S. Yip. The Global Logic of Strategic Alliances, Kenichi Ohmae. 14. Managing Change. Convergence and Upheaval: Managing the Unsteady Pace of Organizatioal Evolution, Michael L. Tushman, Illiam H. Newman, and Elaine Romanelli. Responding to Crisis, William H. Starbuck, Arent Greve, and Bo L. T. Hedberg. Designing Turnaround Strategies, Charles W. Hofer. 15. Thinking Strategically. Strategy Follows Structure: Developing Distinctive Skills, Thomas J. Peters. Myth of the Well-Educated Manager, J. Sterling Livingston. IV. CASES. Edward Marshall Boehm. E&J Gallo Winery. General Mills, Inc. IBM (A): The System/360 Decision. Sony Corporation. New! W.L. Gore and Associates. New! National Westminster Bank, U.S.A. Peet, Russ, Anderson and Detroit. New! Microsoft Corporation. New! The Boston YWCA: 1991. New! Cadbury Schweppes, PLC. Zayre Corporation. Case Notes. Bibliography. Indexes.
Direct production of alkyl levulinates from cellulosic biomass by a single-step acidic solvolysis system at ambient atmospheric pressure.

A simple method was invented to achieve a high yield of cellulosic biomass-derived alkyl levulinates, which have the potential to be alternative fuel additives. Alkyl levulinates, such as butyl-, pentyl-, and hexyl levulinates, were produced using single-step acid-catalyzed solvolysis of cellulosic biomass without the use of elevated pressure. Reactions were performed by refluxing alcohols such as 1-butanol, 1-pentanol, and 1-hexanol at their boiling points of 117, 138, and 157 °C, respectively, with sulfuric acid at ambient pressure. After 1 hour of the reaction, the cellulosic biomass was converted into an alcohol-soluble compound, and a high yield of alkyl levulinates was achieved. Although the process involved simple treatment under atmospheric pressure, the alkyl levulinate yield was quite high: 60 to 80% based on the hexose content of the cellulosic biomass. The factors influencing the reaction, such as the accessibility to cellulose and acidity of the reaction media, could be controlled appropriately in this solvolysis system.
Maternal recasts and activity variations: A comparison of mother--child dyads involving children with and without SLI

Abstract This study investigated maternal recast and the children’s responses comparing dyads made up of a mother and a child with typical language development (TD) or a child with specific language impairment (SLI). More specifically, this article deals with the influence of the type of activity being carried out on the number and types of maternal recasts. A sample of 17 French-speaking children with SLI (age 5 to 7 years) matched with 17 TD same-age peers was observed in interaction with their mother during four different activities (joint reading, symbolic play, question guessing game and clue guessing game). The results showed that group and activity had an impact on the number and type of recasts. Mothers of children with SLI offered more recasts than mothers of TD children. The former preferred phonological recasts whereas the latter preferred lexical ones. Moreover, recasts were more frequently used in joint reading than in other activities. Regarding the children’s responses, no significant difference was observed between the two groups. Children with SLI took up the maternal proposition more frequently after a lexical recast than after a recast of another type. The findings provide evidence for considering the features of the activities in clinical settings.
A myeloproliferative disorder with eosinophilia associated with a unique translocation (3;5)

An association between eosinophilia and a structural chromosome abnormality has been noted in patients with acute non‐lymphoblastic leukaemia (ANLL) and a deletion of the long arm of chromosome 16. There have been a number of other associations of specific chromosome abnormalities with neoplastic diseases involving the eosinophilic lineage; these include chromosome 12 short arm rearrangements, trisomy 8, t(8;21), t(5;14) and t(5;12). We report a patient with a myeloproliferative disorder characterized by chronic eosinophilic leukaemia complicated by autoimmune haemolytic anaemia and a previously unreported translocation (3;5)(p13;q13), and discuss the possible contribution of the RASA gene, localized to 5q13.3, to the development of the malignant phenotype.
Size-Dependent Drift of Resistance Due to Surface Defect Relaxation in Conductive-Bridge Memory

Conductive-bridge random access memory (CBRAM) devices have shown low-power programming, fast switching, and good device scalability. In particular, the large resistance window and good control of the conductive filament (CF) size may allow for efficient multilevel-cell (MLC) operation. Toward this aim, the structural stability of the CF must be demonstrated. This letter addresses the stability of the set states in CBRAM. We evidence a size-dependent drift of the CF resistance, which is interpreted by surface relaxation due to defect rearrangement. An analytical model is developed, describing the size-dependent drift in terms of partial and full depletion of the CF by the surface defect.
Moral hazard, vertical integration, and public monitoring in credence goods

Moral hazard is a problem in markets where the qualities or characteristics of products cannot be verified with certainty by consumers. Here we demonstrate that vertical integration is one possible way of dealing with such problems. When the saving of monitoring costs is the driving force behind vertical integration, public monitoring freely available to the market may prevent vertical integration. Copyright 2002, Oxford University Press.
Time-lapse data prediction by Marchenko-based reservoir transplantation

In a time-lapse experiment, changes in a reservoir cause changes in the reflection response. We discuss a method which predicts these changes from the baseline survey and a model of the changed reservoir. This method, which takes all multiple scattering into account, is significantly more efficient than modeling the response of the entire medium containing the changed reservoir. This can be particularly attractive for applications in time-lapse full wave form inversion, which requires repeated modelling of the reflection response.
La « demand response » dans un marché interconnecté : outil d’efficacités énergétiques et environnementales

Dans cet article, nous etudions les effets d’un effacement de consommation electrique dans un marche interconnecte. Nous montrons que cette reduction induit des gains en efficacites energetiques (reduction des couts de l’energie) et environnementales (reduction des emissions de gaz a effet de serre). Ces gains en efficacites sont croissants avec le niveau de reduction de la demande electrique. Cependant, les gains supplementaires lies a l’augmentation des consommations effacees sont de moins en moins importants au fur et a mesure que l’effacement croit. Ce resultat suggere une preference pour la mise en place d’outils de maitrise de la demande simples et moins couteux, notamment lorsqu’il existe un fort risque de reports des consommations effacees.
Tumor-Suppressive microRNAs in Lung Cancer: Diagnostic and Therapeutic Opportunities

Lung cancer is the leading cause of cancer-related death for both men and women in the U.S. As for many other cancer types, lung cancer is not a single disease, but rather a variety of diseases that present different histopathological, molecular and clinical characteristics. Improved diagnostic and therapeutic tools are needed to manage and treat lung cancer patients. microRNAs are a recently discovered class of short, noncoding RNAs that constitute a novel and functionally important layer of gene regulation. Using new mouse transgenic models for lung cancer, Liu and colleagues reported a genome-wide microRNA expression analysis and identified a signature of down-regulated microRNAs in lung cancer tissues relative to adjacent normal lung. This signature was validated in clinical specimens from lung cancer patients, underscoring the relevance of this profile to human lung cancer. In vitro experiments demonstrated that restoring miR-34c, miR-145, or miR-142-5p expression markedly diminished proliferation of lung cancer cell lines. Here, we discuss the clinical implications of these findings for lung cancer biology, therapy, and prevention.
Self base pairing in a complementary deoxydinucleoside monophosphate duplex: crystal and molecular structure of deoxycytidylyl-(3'-5')-deoxyguanosine.

The molecular structure of ammonium deoxycytidylyl-(3'-5')-deoxyguanosine, crystallized from aqueous acetone near pH 4, was determined for X-ray diffraction data. The crystals were tetragonal, space group P43212 with a = b = 11.078 (1) A and c = 45.826 (4) A. The structure was solved by tangent expansion of phases based on a derived phosphorus position and refined to R = 0.060 by full matrix least squares. Molecules related by a 2-fold symmetry axis are connected by hydrogen bonds between the bases and form parallel right-handed duplexes. Pairs of cytosines share a proton at N(3) and are joined by three hydrogen bonds: N(4)-H.O(2). H-N(4), and N(3)-H.N(3). Guanines are joined by two hydrogen bonds: N(2)-H.N(3) and N(3). H-N(2). Base-stacking interactions within the duplex are weak with the cytosine and guanine ring planes inclined at 24 degrees to each other in each monomer. Despite the unusual arrangement of the molecules, the sugar phosphate backbone has the g-g- conformation normally associated with right-handed double helical structures. Conformational parameters of the nucleosides are also typical with both sugars C(2')-endo and glycosidic torsion angles 55 degrees for cytidine and 94 degrees for guanosine. The bonding geometry of the bases is influenced by hydrogen bonding and charge-transfer networks in the crystal lattice. The solvent molecules interact with the dimer in three fused circular hydrogen bonding domains with a single disordered ammonium cation per d(CpG) dimer. Parallels with the formation of self base pairs and their implications in molecular biology are discussed.