Miracle-dz/UniFAR-FTUs huggingface dataset:
Beyond Happy Families: A Critical Reevaluation of the Control-Resistance-Identity Triangle

In this article, the author explores the natureof contemporary organizational controls, the extent towhich they can be said to colonize employeesubjectivity, and the types of resistance which theygenerate. Labor process, psychoanalytic, critical theory,and Foucauldian perspectives are juxtaposed and a numberof similarities and divergences are noted. It is arguedthat many of these perspectives prematurely lament the end of employee recalcitrance andexaggerate the magnitude and totality of organizationalcontrols, generating over-managed and overcontrolledimages of individuals, organizations, and societies. It is proposed that a rapprochement ofpsychoanalytic and labor theory approaches can lead toan appreciation of unmanaged and unmanageable terrainsin organizations, in which human agency may berediscovered, neither as a class-conscious proletariat nor asa transcendental subject, but as a struggling, feeling,thinking, suffering subject, one capable of obeying anddisobeying, controlling and being controlled, losing control and escaping control, definingand redefining control for itself and forothers.
Effect of Surface Pre-Treatments on the Formation and Degradation Behaviour of a Calcium Phosphate Coating on Pure Magnesium

Calcium phosphate (CaPh) coatings are considered promising surface treatments for Mg-based implants. Normally, the phase conversion process of CaPh compounds occurs during immersion in simulated body fluid (SBF) and allows the easy penetration of a corrosive medium. To solve the issue, pre-treatment is often performed, creating an effective barrier that further improves the corrosion resistance of the underlying Mg. In the present work three pre-treatments including hydrothermal treatment, anodization, and plasma electrolytic oxidation (PEO) were performed on pure Mg prior to CaPh deposition. Results indicated that the composition, morphology, and thickness of the CaPh coatings were strongly influenced by the pre-treatments. Dicalcium phosphate dihydrate (DCPD) was formed on PEO surface, whilst DCPD and hydroxyapatite (HA) were deposited on hydrothermally prepared and anodized surfaces. HA could be deposited on the studied samples during immersion in SBF. The electrochemical impedance spectrum indicated that CaPh coating combined with PEO pre-treatment had the highest corrosion resistance at 120 h due to the superior barrier properties conferred by the PEO layer.
Human cryptosporidiosis: a review.

OBJECTIVE To provide an overview of risk factors, presentation and management of human cryptosporidium infection. DATA SOURCES Literature review was obtained through PubMed search. DATA SELECTION Published articles on the taxonomy of Cryptosporidium and the epidemiology, clinical presentation and management of cryptosporidiosis were reviewed. DATA EXTRACTION AND SYNTHESIS Abstracts and complete articles relevant to the objective were selected, read and analysed to extract information for this article. CONCLUSIONS Human cryptosporidiosis is a severe diarrhoeal disease in malnourished children and immuno-compromised adults in whom it confers poor prognosis. Management is mainly supportive as drug therapy remains elusive. Fortunately the prevalence in AIDS patients is declining due to the widespread use of combination antiretroviral therapy (cART).
Impacts of packet filling in an optical packet switching architecture

Increase in network traffic and emergence of a variety of applications requiring different QoS necessitate scalable and efficient resource utilization. An appealing solution for backbone networks is the optical packet switching architecture. However technological constraints prevent the deployment of such all-optical solutions. Instead, feasible optic-electrical hybrid systems are gaining importance. In this paper, first we briefly describe such an architecture and then focus on the edge part. More specifically, we focus on the optical packet creation process in the edge. The impacts of this optical packet creation mechanism on the incoming traffic profile are investigated. Finally we show, by exploiting service differentiation, that we can improve the optical packet creation mechanisms and use bandwidth more efficiently.
A tool for assessing continuity of care across care levels: an extended psychometric validation of the CCAENA questionnaire

Background The CCAENA questionnaire was developed to assess care continuity across levels from the patients’ perspective. The aim is to provide additional evidence on the psychometric properties of the scales of this questionnaire. Methods Cross-sectional study by means of a survey of a random sample of 1500 patients attended in primary and secondary care in three health care areas of the Catalan health care system. Data were collected in 2010 using the CCAENA questionnaire. To assess psychometric properties, an exploratory factor analysis was performed (construct validity) and the item-rest correlations and Cronbach's alpha were calculated (internal consistency). Spearman correlation coefficients were calculated (multidimensionality) and the ability to discriminate between groups was tested. Results The factor analysis resulted in 21 items grouped into three factors: patient–primary care provider relationship, patient–secondary care provider relationship and continuity across care levels. Cronbach's alpha indicated good internal consistency (0.97, 0.93, 0.80) and the correlation coefficients indicated that dimensions can be interpreted as separated scales. Scales discriminated patients according to health care area, age and educational level. Conclusion The CCAENA questionnaire has proved to be a valid and reliable tool for measuring patients’ perceptions of continuity. Providers and researchers could apply the questionnaire to identify areas for health care improvement.
Contesting Science by Appealing to Its Norms

This study examines the rhetorical aspects of social contestation of climate change in reader comments published in the Daily Mail, subsequent to climategate. The following themes are reported: (1) denigration of climate scientists to contest hegemonic representations, (2) delegitimization of pro–climate change individuals by disassociation from science, and (3) outright denial: rejecting hegemonic social representations of climate change. The study outlines the discursive strategies employed in order to construct social representations of climate change, to contest alternative representations, and to convince others of the validity of these representations. It examines how social representations of science are formed, maintained, and disseminated.
Impact of antiretroviral therapy on viral tropism in HIV-infected patients followed longitudinally for over 5 years.

BACKGROUND Viral tropism plays a major role in HIV pathogenesis and may influence the activity of entry inhibitors. The impact of antiretroviral therapy use on the dynamics of viral tropism over time is still poorly understood. PATIENTS AND METHODS HIV co-receptor usage was determined longitudinally for over 5 years in 237 plasma specimens collected from 73 distinct HIV-1-infected drug-naive individuals, 42 of whom initiated antiretroviral therapy thereafter and 31 who remained untreated. Viral tropism was estimated genotypically using the phenotype predictor software webPSSM, considering as X4 virus populations those with pure X4 and dual/mixed X4/R5 variants. RESULTS At baseline, the prevalence of X4 viruses was 3.2% and 14.6% in patients who remained untreated and in those who initiated antiretroviral therapy, respectively (P = 0.112). Mean plasma HIV-RNA was lower in the former compared with the latter (3.8 +/- 0.9 versus 4.5 +/- 0.9 log; P < 0.004), while conversely the mean CD4 count was greater in untreated than in those who had begun therapy (536 +/- 191 versus 278 +/- 192 cells/mm3; P < 0.001). During follow-up, switch in co-receptor use occurred overall in 26% of the study population, with no significant differences between the groups. Emergence of X4 viruses was significantly associated with lower CD4 counts regardless of antiretroviral treatment exposure. CONCLUSIONS The use of antiretroviral therapy does not seem to influence the selection of X4 viruses, which mainly occur in patients with low CD4 counts.
In vitro and in vivo activities of a new quinolone, WIN 57273, possessing potent activity against gram-positive bacteria

The antibacterial activity of a new 7-dimethylpyridinyl quinolone, WIN 57273, was assessed by using in vitro and in vivo models. Agar inclusion and broth dilution in vitro tests revealed broad-spectrum activity against gram-positive and selected gram-negative organisms, with the greatest potency observed against the staphylococci. The MIC for 90% of coagulase-positive strains tested (MIC90) was less than or equal to 0.002 micrograms/ml; for the coagulase-negative strains the MIC90 was 0.008 micrograms/ml. Against enterococci the MIC90 was 0.06 micrograms/ml, with comparable activity observed against group A and group B streptococci as well as against the pneumococci. In general, the MIC90s for the gram-negative bacteria were less than or equal to 1 micrograms/ml. Exceptions were Serratia marcescens (MIC90, 16 micrograms/ml), Citrobacter freundii (MIC90, 4 micrograms/ml), and Pseudomonas aeruginosa (MIC90, 8 micrograms/ml). The greatest potency was observed against Haemophilus spp. and Neisseria spp. , with MIC90s of 0.06 and 0.016 micrograms/ml, respectively. Broad-spectrum activity was also observed against anaerobes, with MIC90s ranging from 0.125 to 0.5 micrograms/ml among the species tested. The in vivo efficacy was determined by using a murine model by calculating the 50% protective doses against a lethal bacterial infection caused by strains of Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes, Listeria monocytogenes, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. The staphylocci were most susceptible, with 50% protective doses for all strains ranging from 0.1 to 0.7 mg/kg. With the exception of the Pseudomonas infection, which was refractory to treatment, animals that were part of the other infection models responded to less than 10 mg/kg. Equivalent activity was seen with the subcutaneous or the oral route of drug administration. WIN 57273 was significantly more potent than ciprofloxacin in treating gram-positive bacterial infections (2- to 20-fold) but was significantly less effective at treating gram-negative bacterial infections (30- to 300-fold).
hp-Version Composite Discontinuous Galerkin Methods for Elliptic Problems on Complicated Domains

In this paper we introduce the $hp$-version discontinuous Galerkin composite finite element method for the discretization of second-order elliptic partial differential equations. This class of methods allows for the approximation of problems posed on computational domains which may contain a huge number of local geometrical features, or microstructures. While standard numerical methods can be devised for such problems, the computational effort may be extremely high, as the minimal number of elements needed to represent the underlying domain can be very large. In contrast, the minimal dimension of the underlying composite finite element space is independent of the number of geometric features. The key idea in the construction of this latter class of methods is that the computational domain $\Omega$ is no longer resolved by the mesh; instead, the finite element basis (or shape) functions are adapted to the geometric details present in $\Omega$. In this paper, we extend these ideas to the discontinuous Galer.
Mobile pediatric emergency response team: patient satisfaction during the novel H1N1 influenza outbreak.

OBJECTIVES The objective was to determine child caregiver satisfaction with a nontraditional pediatric emergency department (ED) venue during the 2009 novel H1N1 influenza outbreak. METHODS Between May 1 and 7, 2009, the Texas Children's Hospital (TCH) ED used a six-bed outdoor facility, the Mobile Pediatric Emergency Response Team (MPERT), to evaluate patients with suspected novel H1N1 influenza. Parents and caregivers of patients evaluated in the MPERT were surveyed by telephone using a validated questionnaire to evaluate satisfaction with the facility. RESULTS Of 353 patients, 155 caregivers (44%) completed questionnaires; 127 had wrong numbers, 71 did not answer, and 15 were on a no-call list. Survey responders felt that nurses and doctors explained concepts well (nurses 92%, doctors 94%), 91% felt TCH prepared them well for taking care of their children at home, 94% were satisfied with the medical care received, and 88% were not bothered by the outdoor setting. When asked to rate their MPERT experience on a scale of 0 (worst possible) to 10 (best possible), the median score was 9 (range 1 to 10). CONCLUSIONS The MPERT facility alleviated patient volume surge and potentially prevented transmission during H1N1 outbreak. While these were health care provider goals, caregiver expectations were also met. Caregivers perceived MPERT as an acceptable alternative to receiving care in the regular ED, felt that physicians and nurses communicated well, and felt that medical care was good to excellent. Use of the MPERT did not negatively affect overall caregiver satisfaction with TCH. These findings suggest that families of pediatric patients are amenable to nontraditional ED venues during periods of ED crowding.
Attention mediates the relation between catastrophizing and pain.

This paper describes the development and investigation of an attentional model of catastrophizing and perceived pain intensity. According to this model, catastrophizers have a propensity to direct their attentional focus toward their pain during aversive stimulation. The increase in attention to pain results in an increase in perceived pain intensity. The central assertion of this model is that the relation between catastrophizing and pain is mediated by an attentional process. In Study 1, catastrophizing was unrelated to the degree of selective attentional focus to pain-related stimuli prior to cold pressor stimulation, although catastrophizing was significantly correlated with subjects' estimates of the percentage of time that they attended to their pain during cold pressor stimulation. In Study 2, catastrophizing was significantly correlated with the degree of attentional focus to pain-related and social-threat related stimuli during cold pressor stimulation. The degree of attentional focus to pain-related stimuli was significantly correlated with reported pain intensity. In Study 3, catastrophizers who were provided with a distraction task reported less pain than catastrophizers who were not provided with a task. Further, catastrophizers who were provided with a distraction task did not differ from non-catastrophizers in reported pain. There was also evidence suggesting that catastrophizers focused on the threatening and emotional value of painful sensations, while non-catastrophizers focused on the concrete sensory aspects of painful sensations during pain. The results of this research are discussed within the context of an attentional model of catastrophizing and pain.
Towards Optimal Power Management: Estimation of Performance Degradation due to DVFS on Modern Processors

The alarming growth of the power consumption of data centers coupled with low average utilization of servers suggests the use of power management strategies. Such actions however require the understanding of the effects of the power management actions on the performance of data center applications running on managed platforms. The goal of our research is to accurately estimate power savings and consequent performance degradation from DVFS and thereby better guide the optimization of a performance/power metric of a platform. Towards that end, this paper presents precise performance and power models for DVFS strategies. Precise models are attained by better modeling the performance behavior of modern out-of-order processors, by taking into account, for instance, the effects of cache miss overlapping. Models are validated using benchmarks from the SPEC CPU2006 suite, which show that the observed degradation always falls within the predicted bounds. Also, the upper bound degradation estimates were up to 43% less than those due to a linear degradation model which allows for the aggressive use of DVFS.
Deep learning for underwater image recognition in small sample size situations

Underwater target recognition is a challenging task due to the unrestricted environment of the ocean. With large datasets, deep learning methods have been applied with great success to the image recognition of objects in the air. However, it has been observed that deep neural networks (DNNs) easily suffer from overfitting with small samples. Underwater image acquisition always requires much manpower and costs a lot, which makes it difficult to obtain enough sample images for training DNNs. Besides, images captured by underwater cameras are usually deteriorated by noise. Taking live fish recognition as an example, we proposed a framework for underwater image recognition in small sample size situations. First, a novel improved median filter was utilized to suppress noise of fish images. Then, a convolutional neural network was employed and pre-trained with images from the world's largest image recognition database-ImageNet. Finally, preprocessed fish images were used to fine tune the pre-trained neural network and test the classification performance. Experimental results showed that the approach is capable of recognizing fish species, which provides an effective way for solving recognition tasks in small sample size situations.
Comprehensive Gene Ontology Mapping Strategies for Improved Biological Inference

Lack of sufficient semantic relationships between pairs of terms coming from the three independent Gene Ontology sub-ontologies, that limit the power to provide complex semantic queries and inference services based on it. By integrating non-lexical and lexical learning strategies into GLUE system, we semi-automatically generate six types of one-to-one mapping paths covered almost half of all GO terms. We believe that the comprehensive ontology mapping strategies might be an effective way to bridge the gap between non-lexical and lexical approaches, as well as improve accuracy and coverage.
Characteristics of Elderly People Readmitted to the Hospital during the First Year after Stroke

Background and Purpose: Readmissions after acute stroke vary over time and with age and comorbidity. Knowledge of the reasons for readmissions and characteristics of readmitted patients is sparse. This 1-year prospective study examined whether readmissions were related to severity of the index stroke or to comorbidity and explored outcomes in readmitted patients with respect to daily life activities and health-related quality of life. Methods: The study included 216 elderly patients (aged ≧70 years) discharged to their homes or a nursing home after index stroke. The main outcomes were readmission rates and reported diagnoses, performance of daily life activities and health-related quality of life. Results: Nearly half (45%) of the patients were readmitted to the hospital after being discharged to their homes. One readmission was most common, and stroke-related diagnoses were most frequently reported as the reason for readmission. Different forms of heart disease were the next most common reason. The readmitted patients were significantly more dependent in daily life activities, and health-related quality of life was significantly lower among this group. Conclusions: Recurrent stroke and sequelae after stroke were major factors behind readmissions, followed by heart disease in elderly stroke patients. The readmitted patients were more dependent in daily life activities and reported a lower health-related quality of life compared with not readmitted patients.
ATP hydrolysis-driven gating in cystic fibrosis transmembrane conductance regulator

Proteins belonging to the ATP-binding cassette superfamily couple ATP binding and hydrolysis at conserved nucleotide-binding domains (NBDs) to diverse cellular functions. Most superfamily members are transporters, while cystic fibrosis transmembrane conductance regulator (CFTR), alone, is an ion channel. Despite this functional difference, recent results have suggested that CFTR shares a common molecular mechanism with other members. ATP binds to partial binding sites on the surface of the two NBDs, which then associate to form a NBD dimer, with complete composite catalytic sites now buried at the interface. ATP hydrolysis and γ-phosphate dissociation, with the loss of molecular contacts linking the two sides of the composite site, trigger dimer dissociation. The conformational signals generated by NBD dimer formation and dissociation are transmitted to the transmembrane domains where, in transporters, they drive the cycle of conformational changes that translocate the substrate across the membrane; in CFTR, they result in opening and closing (gating) of the ion-permeation pathway.
Monitoring disease progression in spinocerebellar ataxias: implications for treatment and clinical research

ABSTRACT Introduction: Spinocerebellar ataxias (SCAs) are autosomal dominant diseases characterized by progressive gait and limb incoordination, disequilibrium, dysarthria, and eye movement disturbances. Approximately 40 genetic subtypes of SCAs are known and classified according to the causative disease gene/locus. With the possibility of the specific genetic diagnosis in patients and at-risk family members, several clinical scales and functional tests have been validated and used in ataxic patients with the purposes of measuring the entity of disease progression in natural history studies and the possible slowing of neurological impairment in therapeutic trials. Areas covered: This paper reviews the most widely used clinical scales and quantitative tests that contributed in monitoring disease progression of the most common forms of SCAs. Expert commentary: The currently available and validated clinical scales and quantitative performance scores are adequate to measure disease severity, but may require a considerable number of subjects and a long period of treatment to allow the recognition of beneficial effect of interventional therapies. Advanced MRI techniques are a consistent biomarker and maybe useful to track disease progression from the preclinical to the manifest ataxic phase in association with appropriate clinical or paraclinical investigations.