Miracle-dz/UniFAR-FTUs huggingface dataset:
Genotoxicity and carcinogenicity of cobalt-, nickel- and copper-based nanoparticles

The nanotechnology industry has matured and expanded at a rapid pace in the last decade, leading to the research and development of nanomaterials with enormous potential. The largest source of these nanomaterials is the transitional metals. It has been revealed that numerous properties of these nano-sized elements are not present in their bulk states. The nano size of these particles means they are easily transported into biological systems, thus, raising the question of their effects on the susceptible systems. Although advances have been made and insights have been gained on the effect of transitional metals on susceptible biological systems, there still is much ground to be covered, particularly with respect to our knowledge on the genotoxic and carcinogenic effects. Therefore, this review intends to summarize the current knowledge on the genotoxic and carcinogenic potential of cobalt-, nickel- and copper-based nanoparticles indicated in in vitro and in vivo mammalian studies. In the present review, we briefly state the sources, use and exposure routes of these nanoparticles and summarize the current literature findings on their in vivo and in vitro genotoxic and carcinogenic effects. Due to the increasing evidence of their role in carcinogenicity, we have also included studies that have reported epigenetic factors, such as abnormal apoptosis, enhanced oxidative stress and pro-inflammatory effects involving these nanoparticles.
Air Pollution and Its Effects in the Respiratory System

1.1 Respiratory system structure and normal function The respiratory system is the gateway for 15,000 liters of air that enter through the nostrils, and after its appropriate conditioning, arrives to the delicate net structured by the lung parenchyma. At this site gas diffusion takes place, and oxygen diffuses through the Pneumocyte I cytoplasm to reach the erythrocyte’s hemoglobin, passing by the endothelial cell. To make this possible, a well-structured conducting system leads the air (trachea, bronchi, bronchioles, alveoli) from the nostrils to the alveoli. A specialized epithelium blankets the tubes, with some local modifications (Fortoul et al., 2010). This epithelium is constituted by a variety of cells with different functions (Figure 1). In the submucose under the bronchi, mucous and serous glands are located, and liberate its secretion to the surface of the epithelium (Figure 2). These glands, as well as the goblet cells, produce mucus that in normal situations is Alcian blue/ PAS+ (Davis & Dicker, 2008). The biochemistry of the mucus, produced by the goblet or the submucosal glands is important because they determinate their viscosity, pH, and charge, as well as its stain affinity (Figure 3) (Rose & Voynow, 2006). With the help of intercellular junctions, this tubes system separates spaces between the epithelium, which is known as interstitial space and it houses connective tissue, fibroblast, lymphocytes, macrophages, and other cells that may migrate from the capillaries. Along these tubes the air that enters through the nostrils becomes moistened, filtered and temperated, to arrive into the alveoli for gas diffusion. A change in the composition and function of the epithelial components will be associated with a variety of diseases which are associated to air pollutants exposure (Figure 4) (Mussali-Galante & Fortoul, 2008).
Rack cooling effectiveness in data centers and telecom central offices : The rack cooling index (RCI). Discussion

Managing today’s dense equipment environments is a challenge; over-temperatures may not only harm expensive electronic equipment but also interrupt critical and/or revenue generating services. This paper is proposing a methodology and an index for analyzing the rack cooling effectiveness in data centers, telecom central offices, and other mission critical facilities. Although Computational Fluid Dynamics (CFD) modeling allows visualization of temperatures throughout equipment rooms, to sort out the cooling effectiveness of different design options can be challenging. By using the same CFD technology, however, the rack intake temperatures can be established. They provide a “complete” picture of the thermal environment for air-cooled equipment. Still, there is no yardstick for interpreting the modeled (or measured) temperatures. This paper proposes a dimensionless index as the vehicle for such a common standard. The Rack Cooling Index (RCI) is designed to be a measure of how effectively equipment racks are cooled and maintained within industry thermal guidelines and standards. By testing the methodology and the index on a typical data center environment with two contrasting cooling systems, it is shown that the index indeed provides a meaningful measure of the rack cooling effectiveness. The index has the capacity to help evaluate the equipment room health for managing existing environments or designing new environments.
Consumption of coffee, green tea, oolong tea, black tea, chocolate snacks and the caffeine content in relation to risk of diabetes in Japanese men and women

Although the inverse association between coffee consumption and risk of diabetes has been reported numerous times, the role of caffeine intake in this association has remained unclear. We evaluated the consumption of coffee and other beverages and food containing caffeine in relation to the incidence of diabetes. The study participants were 5897 men and 7643 women in a community-based cohort in Takayama, Japan. Consumption of coffee, green tea, oolong tea, black tea and chocolate snacks were measured with a semi-quantitative FFQ in 1992. At the follow-up survey in 2002, the development of diabetes and the time of diagnosis were reported. To assess the association, age, smoking status, BMI, physical activity, education in years, alcohol consumption, total energy intake, fat intake and women's menopausal status were adjusted. Among men who consumed one cup per month to six cups per week and among those who consumed one cup per d or more, the associated hazard ratios were 0·69 (95 % CI 0·50, 0·97) and 0·69 (95 % CI 0·49, 0·98) compared with those who drank little to no coffee, with a P value for trend of 0·32. The hazard ratios for women with the same coffee consumption patterns were 1·08 (95 % CI 0·74, 1·60) and 0·70 (95 % CI 0·44, 1·12), with a P value for trend of 0·03. The association between estimated total caffeine intake and risk of diabetes was insignificant both among men and among women. The results imply that coffee consumption decreased the risk of developing diabetes. The protective effect may exist aside from the influence of caffeine intake.
A pr 2 01 8 Atomic Bright Soliton Interferometry

The properties of nonlinear interference pattern between atomic bright solitons are characterized analytically, with the aid of exact solutions of dynamical equation in mean-field approximation. It is shown that relative velocity, relative phase, and nonlinear interaction strength can be measured from the interference pattern. The nonlinear interference properties are proposed to design atomic soliton interferometry in Bose-Einstein condensate. As an example, we apply them to measure gravity acceleration in a ultra-cold atom systems with a high precision degree. The results are also meaningful for precise measurements in optical fiber, water wave tank, plasma, and other nonlinear systems.
ROLE OF DIFFERENT INGREDIENTS OF TOOTH PASTES AND MOUTHWASHES IN ORAL HEALTH

Many different kind of ingredients are incorporated in toothpastes and mouthwashes to keep the oral health in a perfect condition. We have different kinds of toothpastes and mouthwashes available in the market like anti-cavity, extra-whitening and toothpaste for sensitive teeth, toothpastes with stripes, clear and even liver flavored toothpaste for dogs. Modern type of toothpaste contains abrasives which help to scour off bacterial films and fluorides to harden the teeth against caries and have thickeners that stay on the toothbrush. The role of detergents is to remove the fatty films, and water softeners to make the detergents work better. The sweeteners play the role as a non-nutritive which may help stop the attraction of bacteria. Different kind of ingredients incorporate such as detergents and phosphates to prevent the awful taste. A variety of mouthwashes are available in the market according to the different oral conditions like antibacterial mouthwash, whiting mouthwash, fluoride mouthwash and bad breath mouthwash which have a strong enough flavor to hide the bad tastes of decaying bits of previous meals. Both mouthwashes and toothpastes contain active and inactive ingredients which have their own importance and will be recommended according to their different oral conditions. : Toothpastes, Mouthwashes, Fluoride,Abrasive, Potassium nitrate, Chlorhexidine
Absence of Genetic Differences among G10P[11] Rotaviruses Associated with Asymptomatic and Symptomatic Neonatal Infections in Vellore, India

ABSTRACT Rotaviruses (RVs) are leading causes of severe diarrhea and vomiting in infants and young children. RVs with G10P[11] genotype specificity have been associated with symptomatic and asymptomatic neonatal infections in Vellore, India. To identify possible viral genetic determinants responsible for differences in symptomology, the genome sequences of G10P[11] RVs in stool samples of 19 neonates with symptomatic infections and 20 neonates with asymptomatic infections were determined by Sanger and next-generation sequencing. The data showed that all 39 viruses had identical genotype constellations (G10-P[11]-I2-R2-C2-M2-A1-N1-T1-E2-H3), the same as those of the previously characterized symptomatic N155 Vellore isolate. The data also showed that the RNA and deduced protein sequences of all the Vellore G10P[11] viruses were nearly identical; no nucleotide or amino acid differences were found that correlated with symptomatic versus asymptomatic infection. Next-generation sequencing data revealed that some stool samples, both from neonates with symptomatic infections and from neonates with asymptomatic infections, also contained one or more positive-strand RNA viruses (Aichi virus, astrovirus, or salivirus/klassevirus) suspected of being potential causes of pediatric gastroenteritis. However, none of the positive-strand RNA viruses could be causally associated with the development of symptoms. These results indicate that the diversity of clinical symptoms in Vellore neonates does not result from genetic differences among G10P[11] RVs; instead, other undefined factors appear to influence whether neonates develop gastrointestinal disease symptoms. IMPORTANCE Rotavirus (RV) strains have been identified that preferentially replicate in neonates, in some cases, without causing gastrointestinal disease. Surveillance studies have established that G10P[11] RVs are a major cause of neonatal infection in Vellore, India, with half of infected neonates exhibiting symptoms. We used Sanger and next-generation sequencing technologies to contrast G10P[11] RVs recovered from symptomatic and asymptomatic neonates. Remarkably, the data showed that the RNA genomes of the viruses were virtually indistinguishable and lacked any differences that could explain the diversity of clinical outcomes among infected Vellore neonates. The sequencing results also indicated that some symptomatic and some asymptomatic Vellore neonates were infected with other enteric viruses (Aichi virus, astrovirus, salvirus/klassevirus); however, none could be correlated with the presence of symptoms in neonates. Together, our findings suggest that other poorly defined factors, not connected to the genetic makeup of the Vellore G10P[11] viruses, influence whether neonates develop gastrointestinal disease symptoms.
A framework for extensible languages

Extensible programming languages such as SugarJ or Racket enable programmers to introduce customary language features as extensions of the base language. Traditionally, systems that support language extensions are either (i) agnostic to the base language or (ii) only support a single base language. In this paper, we present a framework for language extensibility that turns a non-extensible language into an extensible language featuring library-based extensible syntax, extensible static analyses, and extensible editor support. To make a language extensible, our framework only requires knowledge of the base language's grammar, the syntax for import statements (which activate extensions), and how to compile base-language programs. We have evaluated the generality of our framework by instantiating it for Java, Haskell, Prolog, JavaScript, and System Fω, and by studying existing module-system features and their support in our framework.
Efficient mapping algorithms for scheduling robot inverse dynamics computation on a multiprocessor system

Two efficient mapping algorithms are presented for scheduling the execution of a robot inverse dynamics computation using a p-processor multiprocessor system where p is the number of identical processors. An objective function is defined in terms of the sum of the processor finishing time and the interprocessor communication time. A minimax optimization is performed on the objective function to obtain the best mapping. This mapping problem is formulated as a combination of a graph partitioning and scheduling problem; both are known to be NP-complete. Computer simulations were performed to evaluate and verify the performance and the validity of the proposed mapping algorithms. Experiments for computing the inverse dynamics of a six-jointed PUMA-like manipulator based on the Newton-Euler dynamic equations were implemented on an NCUBE/ten hypercube computer to verify the proposed mapping algorithms. >
Uncertainty Quantification in Fatigue Damage Prognosis

This paper presents a methodology to quantify the uncertainty in fatigue damage prognosis, applied to structures with complicated geometry and subjected to variable amplitude multi-axial loading. Finite element analysis is used to address the complicated geometry and calculate the stress intensity factors. Multi-modal stress intensity factors due to multi-axial loading are combined to calculate an equivalent stress intensity factor using a characteristic plane approach. Crack growth under variable amplitude loading is modeled using a modified Paris law that includes Wheeler’s crack retardation model. During cycle-by-cycle integration of the crack growth law, a Gaussian process surrogate model is used to replace the expensive finite element analysis, resulting in rapid computation. The effect of different kinds of uncertainty – physical variability, data uncertainty and modeling errors – on crack growth prediction is investigated. The various sources of uncertainty include, but not limited to, variability in loading conditions, material parameters, experimental data, model uncertainty, etc. Three different kinds of modeling errors – crack growth model error, discretization error and surrogate model error – are included in analysis. The different kinds of uncertainty are incorporated into the prognosis methodology to predict the probability distribution of crack size as a function of number of load cycles. The proposed method is illustrated using an application problem, surface cracking in a cylindrical structure.
Novel aspects of the pathogenesis of aneurysms of the abdominal aorta in humans

Aneurysm of the abdominal aorta (AAA) is a particular, specifically localized form of atherothrombosis, providing a unique human model of this disease. The pathogenesis of AAA is characterized by a breakdown of the extracellular matrix due to an excessive proteolytic activity, leading to potential arterial wall rupture. The roles of matrix metalloproteinases and plasmin generation in progression of AAA have been demonstrated both in animal models and in clinical studies. In the present review, we highlight recent studies addressing the role of the haemoglobin-rich, intraluminal thrombus and the adventitial response in the development of human AAA. The intraluminal thrombus exerts its pathogenic effect through platelet activation, fibrin formation, binding of plasminogen and its activators, and trapping of erythrocytes and neutrophils, leading to oxidative and proteolytic injury of the arterial wall. These events occur mainly at the intraluminal thrombus–circulating blood interface, and pathological mediators are conveyed outwards, where they promote matrix degradation of the arterial wall. In response, neo-angiogenesis, phagocytosis by mononuclear cells, and a shift from innate to adaptive immunity in the adventitia are observed. Abdominal aortic aneurysm thus represents an accessible spatiotemporal model of human atherothrombotic progression towards clinical events, the study of which should allow further understanding of its pathogenesis and the translation of pathogenic biological activities into diagnostic and therapeutic applications.
Reliable Top-Left Light Convention Starts With Early Renaissance: An Extensive Approach Comprising 10k Artworks

Art history claims that Western art shows light from the top left, which has been repeatedly shown with narrow image sets and simplistic research methods. Here we employed a set of 10,000 pictures for which participants estimated the direction of light plus their confidence of estimation. From 1420 A.D., the onset of Early Renaissance, until 1900 A.D., we revealed a clear preference for painting light from the top left—within the same period, we observed the highest confidence in such estimations of the light source. One sentence summary This study demonstrates a robust preference for painting light from the top left for Western art history, starting from Early Renaissance until 1900.
DU Electronic Theses and Dissertations Graduate Studies 1-1-2011 Minimax and Maximin Fitting of Geometric Objects to Sets of Points

This thesis addresses several problems in the facility location sub-area of computational geometry. Let S be a set of n points in the plane. We derive algorithms for approximating S by a step function curve of size k < n, i.e., by an x-monotone orthogonal polyline R with k < n horizontal segments. We use the vertical distance to measure the quality of the approximation, i.e., the maximum distance from a point in S to the horizontal segment directly above or below it. We consider two types of problems: min -ε, where the goal is to minimize the error for a given number of horizontal segments k and min -#, where the goal is to minimize the number of segments for a given allowed error ε. AfterO(n) preprocessing time, we solve instances of the latter in O(min{k log n, n}) time per instance. We can then solve the former problem in O(min{n, nk log n}) time. Both algorithms require O(n) space. The second contribution is a heuristic for the min -ε problem that computes a solution within a factor of 3 of the optimal error for k segments, or with at most the same error as the k-optimal but using 2k − 1 segments. Furthermore, experiments on real data show even better results than what is guaranteed by the theoretical bounds. Both approximations run in O(n log n) time and O(n) space. Then, we present an exact algorithm for the weighted version of this problem that runs in O(n) time and generalize the heuristic to handle weights at the expense of an additional log n factor. At this point, a randomized
Association of protein intake with the change of lean mass among elderly women: The Osteoporosis Risk Factor and Prevention – Fracture Prevention Study (OSTPRE-FPS)

Abstract Low protein intake can lead to declined lean mass (LM) in elderly. We examined the associations of total protein (TP), animal protein (AP) and plant protein (PP) intakes with LM. The association of TP intake with LM change was further evaluated according to weight change status. This cross-sectional and prospective cohort study included 554 women aged 68 (sd 1·9) years from the Osteoporosis Risk Factor and Prevention – Fracture Prevention Study (OSTPRE-FPS). The intervention group (n 270) received daily cholecalciferol (800 IU; 20 μg) and Ca (1000 mg) for 3 years while the control group received neither supplementation nor placebo (n 282). Participants filled out a questionnaire on lifestyle factors and a 3-d food record in 2002 and underwent dual-energy X-ray absorptiometry for body composition measurements at baseline and 3 years. Multiple linear regressions evaluated the association between protein intake and LM, adjusting for relevant covariates. At the baseline TP and AP intakes were positively associated with LM and trunk LM, TP was associated also with appendicular LM (aLM). Follow-up results showed that in the total population and the intervention group, higher TP and AP were associated with increased LM and aLM (P ≤ 0·050). No such associations were observed in the control group. PP intake was also associated with aLM change in the total population. Overall, the associations were independent of fat mass. Further, among weight maintainers, TP intake was positively associated with LM, aLM and trunk LM changes (P ≤ 0·020). In conclusion, dietary TP, especially AP, intake may be a modifiable risk factor for sarcopenia by preserving LM in the elderly.
Coplanar stripline components for high frequency applications

In this paper, coplanar stripline discontinuities such as a slit, a right angle bend and a T-junction are characterized and their performance is parameterized with respect to frequency and geometry. Lumped equivalent circuits are presented for some of them. The element values are obtained from the measured discontinuity scattering (S) parameters. The experimental results are compared with theoretical data obtained using the Finite Difference Time Domain (FD-TD) technique for validation and show very good agreement.
Rabbit anti-thymocyte globulin induction in renal transplantation: review of the literature

Rabbit anti-thymocyte globulin (rATG) has proven benefit as induction therapy in renal transplant recipients, achieving reduced acute rejection rates and better short-term allograft function, with slightly higher rates of complications such as infections and malignancy. Compared with other agents, the most benefit from rATG induction has been observed in renal transplant recipients at high immunologic risk for rejection. However, in special populations, such as pediatrics, the elderly, and hepatitis C-positive and human immunodeficiency virus-positive renal transplant recipients, additional information is needed to delineate the absolute benefit of rATG induction compared with other induction agents. Selection of rATG as the choice of induction therapy in renal transplant recipients should be guided by a cost-effective approach in balancing efficacy, safety, and cost. This review summarizes the published literature on efficacy, safety, and cost of rATG induction in renal transplantation.
Thermo-Mechanical Analysis of Si3N4-Based Seal Coatings on Si3N4 Substrate

In this Study, a Good Combination between Si3N4-Based Seal Coatings and Porous Si3N4 Substrate Was Achieved by Room Temperature Spraying and Pressureless Sintering. To Evaluate the Joint Quality, Residual Stress due to Thermal Expansion Mismatch between the Coatings and Porous Layers Were Characterized by Computational Studies Using the Finite Element ANSYS Code. It Was Found that Si3N4-Based Seal Coating Allows a Gradual Change in Thermal Expansion Mismatch, Minimizing the Thermal Stresses Arising from Cooling or Heating. Further Theoretical Analysis Indicates that the Thermal Expansion Mismatch between the Two Layers Produced a Large Strengthening Effect for the Fraction of the Porosity below a Critical Level and that Substrates with the High Fraction of Porosity Showed Complete Cracking, as the Cracks Initiating in Adjacent Coatings. And the Volume Fraction of Pores Required to Cause Crack Deflection, in the Porous Layer, Was Predicted. The Effects of Layer Thickness and Porosity Fraction on Residual Stress Were Studied, which Are Used as Predictions towards Better Design of Composite Materials.