Miracle-dz/UniFAR-FTUs huggingface dataset:
Portulaca oleracea L.: A Review of Phytochemistry and Pharmacological Effects

Portulaca oleracea L. , belonging to the Portulacaceae family, is commonly known as purslane in English and Ma-Chi-Xian in Chinese. It is a warm-climate, herbaceous succulent annual plant with a cosmopolitan distribution. It is eaten extensively as a potherb and added in soups and salads around the Mediterranean and tropical Asian countries and has been used as a folk medicine in many countries. Diverse compounds have been isolated from Portulaca oleracea, such as flavonoids, alkaloids, polysaccharides, fatty acids, terpenoids, sterols, proteins vitamins and minerals. Portulaca oleracea possesses a wide spectrum of pharmacological properties such as neuroprotective, antimicrobial, antidiabetic, antioxidant, anti-inflammatory, antiulcerogenic, and anticancer activities. However, few molecular mechanisms of action are known. This review provides a summary of phytochemistry and pharmacological effects of this plant.
Sustainability Design and Software: The Karlskrona Manifesto

Sustainability has emerged as a broad concern for society. Many engineering disciplines have been grappling with challenges in how we sustain technical, social and ecological systems. In the software engineering community, for example, maintainability has been a concern for a long time. But too often, these issues are treated in isolation from one another. Misperceptions among practitioners and research communities persist, rooted in a lack of coherent understanding of sustainability, and how it relates to software systems research and practice. This article presents a cross-disciplinary initiative to create a common ground and a point of reference for the global community of research and practice in software and sustainability, to be used for effectively communicating key issues, goals, values and principles of sustainability design for software-intensive systems.The centrepiece of this effort is the Karlskrona Manifesto for Sustainability Design, a vehicle for a much needed conversation about sustainability within and beyond the software community, and an articulation of the fundamental principles underpinning design choices that affect sustainability. We describe the motivation for developing this manifesto, including some considerations of the genre of the manifesto as well as the dynamics of its creation. We illustrate the collaborative reflective writing process and present the current edition of the manifesto itself. We assess immediate implications and applications of the articulated principles, compare these to current practice, and suggest future steps.
Toll-Like Receptor -1, -2, and -6 Polymorphisms and Pulmonary Tuberculosis Susceptibility: A Systematic Review and Meta-Analysis

Background A large number of studies have investigated whether polymorphisms in the Toll-like receptor (TLR) genes are implicated in susceptibility to tuberculosis (TB) in different populations. However, the results are inconsistent and inconclusive. Methods A literature search was conducted using the PubMed, EMBASE, Medline (Ovid), ISI Web of Knowledge and Chinese National Knowledge Infrastructure (CNKI). A meta-analysis on the associations between the TLR1 G1805T, TLR2 T597C, T1350C, G2258A, and TLR6 C745T polymorphisms and TB risk was carried out by comparison using different genetic models. Results In total, 16 studies from 14 articles were included in this review. In meta-analysis, significant associations were observed between the TLR2 2258AA (AA vs. AG+AG, OR 5.82, 95% CI 1.30–26.16, P = 0.02) and TLR6 745TT (TT vs. CT+CC, OR 0.61, 95% CI 0.39–0.97, P = 0.04) polymorphisms and TB risk. In the subgroup analysis by ethnicity, Africans and American Hispanic subjects with the TLR1 1805T allele had an increased susceptibility, whereas Asian and European subjects with the TLR2 2258A allele had an increased susceptibility to TB. Conclusions The meta-analysis indicated that TLR2 G2258A is associated with increased TB risk, especially in Asians and Europeans. TLR1 G1805T is associated with increased TB in Africans and American Hispanics. TLR6 C745T is associated with decreased TB risk. Our systematic review and meta-analysis reported an interesting preliminary conclusion, but this must be validated by future large-scale and functional studies in different populations.
Performance analysis and the study of the behavior of MPLS protocols

MultiProtocol label switching (MPLS) is the new means to take care of the fastest growing communication network to enhance the speed, scalability and service provisioning capabilities. In order to optimize the use of transmission resources, MPLS carries differentiated services across the Internet through a virtual path capability between packet (label) switches. MPLS also has the capabilities to engineer traffic tunnels by avoiding congestion and utilizing all available bandwidth with an efficient manner. The core value of MPLS is followed by the comparison of MPLS network with the existing network and MPLS signaling protocols: constrained based label distribution protocol (CR-LDP), resource reservation protocol (RSVP) and traffic extension RSVP (RSVP-TE) maintaining the quality of service (QoS) parameters and their performance analysis as well. In such context, a full comprehensive simulation environment is created for a conventional network and MPLS applied over that traditional network to evaluate the comparative performance of network traffic behavior and the functionalities of MPLS signaling protocols as well. Finally, the results are evaluated and analyzed, and their behaviors are shown by means of graphical manner.
Exposure to Degrading Versus Nondegrading Music Lyrics and Sexual Behavior Among Youth

BACKGROUND. Early sexual activity is a significant problem in the United States. A recent survey suggested that most sexually experienced teens wish they had waited longer to have intercourse; other data indicate that unplanned pregnancy and sexually transmitted diseases are more common among those who begin sexual activity earlier. Popular music may contribute to early sex. Music is an integral part of teens' lives. The average youth listens to music 1.5 to 2.5 hours per day. Sexual themes are common in much of this music and range from romantic and playful to degrading and hostile. Although a previous longitudinal study has linked music video consumption and sexual risk behavior, no previous study has tested longitudinal associations between the content of music lyrics and subsequent changes in sexual experience, such as intercourse initiation, nor has any study explored whether exposure to different kinds of portrayals of sex has different effects. DESIGN AND PARTICIPANTS. We conducted a national longitudinal telephone survey of 1461 adolescents. Participants were interviewed at baseline (T1), when they were 12 to 17 years old, and again 1 and 3 years later (T2 and T3). At all of the interviews, participants reported their sexual experience and responded to measures of more than a dozen factors known to be associated with adolescent sexual initiation. A total of 1242 participants reported on their sexual behavior at all 3 time points; a subsample of 938 were identified as virgins before music exposure for certain analyses. Participants also indicated how frequently they listened to each of more than a dozen musical artists representing a variety of musical genres. Data on listening habits were combined with results of an analysis of the sexual content of each artist's songs to create measures of exposure to 2 kinds of sexual content: degrading and nondegrading. OUTCOME MEASURES. We measured initiation of intercourse and advancement in noncoital sexual activity level over a 2-year period. RESULTS. Multivariate regression analyses indicated that youth who listened to more degrading sexual content at T2 were more likely to subsequently initiate intercourse and to progress to more advanced levels of noncoital sexual activity, even after controlling for 18 respondent characteristics that might otherwise explain these relationships. In contrast, exposure to nondegrading sexual content was unrelated to changes in participants' sexual behavior. CONCLUSION. Listening to music with degrading sexual lyrics is related to advances in a range of sexual activities among adolescents, whereas this does not seem to be true of other sexual lyrics. This result is consistent with sexual-script theory and suggests that cultural messages about expected sexual behavior among males and females may underlie the effect. Reducing the amount of degrading sexual content in popular music or reducing young people's exposure to music with this type of content could help delay the onset of sexual behavior.
Characterization of Streptococcus mutans Strains Deficient in EIIABMan of the Sugar Phosphotransferase System

ABSTRACT The phosphoenolpyruvate:sugar phosphotransferase system (PTS) is the major sugar uptake system in oral streptococci. The role of EIIABMan (encoded by manL) in gene regulation and sugar transport was investigated in Streptococcus mutans UA159. The manL knockout strain, JAM1, grew more slowly than the wild-type strain in glucose but grew faster in mannose and did not display diauxic growth, indicating that EIIABMan is involved in sugar uptake and in carbohydrate catabolite repression. PTS assays of JAM1, and of strains lacking the inducible (fruI) and constitutive (fruCD) EII fructose, revealed that S. mutans EIIABMan transported mannose and glucose and provided evidence that there was also a mannose-inducible or glucose-repressible mannose PTS. Additionally, there appears to be a fructose PTS that is different than FruI and FruCD. To determine whether EIIABMan controlled expression of the known virulence genes, glucosyltransferases (gtfBC) and fructosyltransferase (ftf) promoter fusions of these genes were established in the wild-type and EIIABMan-deficient strains. In the manL mutant, the level of chloramphenicol acetyltransferase activity expressed from the gtfBC promoter was up to threefold lower than that seen with the wild-type strain at pH 6 and 7, indicating that EIIABMan is required for optimal expression of gtfBC. No significant differences were observed between the mutant and the wild-type background in ftf regulation, with the exception that under glucose-limiting conditions at pH 7, the mutant exhibited a 2.1-fold increase in ftf expression. Two-dimensional gel analysis of batch-grown cells of the EIIABMan-deficient strain indicated that the expression of at least 38 proteins was altered compared to that seen with the wild-type strain, revealing that EIIABMan has a pleiotropic effect on gene expression.
Implementation of an Appropriate Household Water Purification System in Tourou, Cameroon

The two goals of this project were to develop a household water purification method and to provide a framework for sustaining this technology in a low-income community. According to the World Health Organization, waterborne diseases are a leading cause of illness and death in developing countries. Over 1.1 billion people across the world lack access to an improved water supply, leading to diseases that disproportionately affect children. Water purification methods used in high-income nations are neither economically nor technically feasible in low-income countries. As a result, there is a critical need for inexpensive, appropriate water purification technologies. The system developed was tested in Tourou, Cameroon
Response of serotonergic caudal raphe neurons in relation to specific motor activities in freely moving cats

Serotonergic neuronal responses during three specific motor activities were studied in nuclei raphe obscurus (NRO) and raphe pallidus (NRP) of freely moving cats by means of extracellular single-unit recordings. Responses to treadmill-induced locomotion were primarily excitatory, with 21 of 24 neurons displaying increased firing rates, directly related to treadmill speed. Individual regression analyses determined three response patterns: maximal activation at low speed (0.25 m/sec), augmentation of neuronal activity only at high treadmill speed (0.77 m/sec), and a linear increase. A smaller fraction of NRO and NRP serotonergic neurons (6 of 27) also responded to hypercarbic ventilatory challenge with increased firing rates. The magnitude of neuronal response was dependent upon the fraction of inspired CO2 and was related to ventilatory motor output, specifically, inspiratory amplitude. A subgroup of neurons responsive to hypercarbia in wakefulness demonstrated significant reductions in neuronal response to hypercarbia in slow-wave sleep. Finally, unit activity for 12 of 29 cells increased in response to spontaneous feeding, displaying two distinct patterns of neuronal response in relation to onset and termination of feeding: rapid activation and deactivation versus a gradual increase and decrease. More than half of the cells studied under all three conditions were responsive to more than one motor task. These results indicate that serotonergic caudal raphe neurons are responsive to specific motor system challenges, with many neurons responsive to multiple motor tasks, and that the responsiveness of serotonergic neurons to at least one motor task, hypercarbic ventilatory challenge, is state dependent.
Perceived Indicators of Deception

Lots of researching has been done about lying and the (facial) behavior revealing them. Even with many of these researches claiming different or not a single behavior being an actual signs of lying, this research shows there are common stereotypes about what people think somebody would do when lying. An experiment with an Embodied Conversational Agent (ECA) has been done to see what facial behaviors are perceived indicators of lying. In a comparison between the different facial behaviors gazing and looking away are the prime suspects.
Multimedia Search Technologies

One of the most ubiquitous activities related to learning in the digital age is “search”. In recent years, computers have rapidly evolved from numeric and text processing to include multimedia, specifically audio, video, and images. However, few methods exist for searching multimedia, apart from textbased strategies operating on keywords, metadata and filenames. Creating text descriptions for multimedia is resourceconsuming and problematic. For example, sounds are difficult to describe in words and as a result, audio collections have been largely inaccessible. This paper will review the different technologies, including open source tools, which have been developed to facilitate multimedia searches. Many of these are based on some form of pattern recognition, and nontextual user input. These tools, though not widely utilized in the world of learning, have tremendous potential to facilitate access to, and reuse of, multimedia, offering benefits to learners and instructional developers.
Lamin A/C Mutants Disturb Sumo1 Localization and Sumoylation in Vitro and in Vivo

A-type lamins A and C are nuclear intermediate filament proteins in which mutations have been implicated in multiple disease phenotypes commonly known as laminopathies. A few studies have implicated sumoylation in the regulation of A-type lamins. Sumoylation is a post-translational protein modification that regulates a wide range of cellular processes through the attachment of small ubiquitin-related modifier (sumo) to various substrates. Here we showed that laminopathy mutants result in the mislocalization of sumo1 both in vitro (C2C12 cells overexpressing mutant lamins A and C) and in vivo (primary myoblasts and myopathic muscle tissue from the LmnaH222P /H222P mouse model). In C2C12 cells, we showed that the trapping of sumo1 in p.Asp192Gly, p.Gln353Lys, and p.Arg386Lys aggregates of lamin A/C correlated with an increased steady-state level of sumoylation. However, lamin A and C did not appear to be modified by sumo1. Our results suggest that mutant lamin A/C alters the dynamics of sumo1 and thus misregulation of sumoylation may be contributing to disease progression in laminopathies.
Simulation-Based Analysis for a Heterogeneous Indoor Localization Scheme

In this paper, we focus on the indoor localization problem and we explore positioning solutions which are based on two popular wireless technologies, namely the wireless LAN (WLAN) and the radio frequency identification (RFID). WLAN-based localizers are easily deployed but suffer from lImited accuracy. On the other hand, RFID-based solutions are more accurate for tracking a single user but are not effiCient in populated environments due to the interference among users. Thus, a technology synergy is proposed for supplementmg their limitations. A simulation-based analysis is provided for evaluating the performance of RFID-based positioning schemes under different environmental conditions and for demonstratmg the potential performance enhancement of each stand-alone solution after being supported from the other.
Neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends on history of psychosis rather than diagnostic group.

OBJECTIVES Neurocognitive dysfunction is milder in bipolar disorders than in schizophrenia spectrum disorders, supporting a dimensional approach to severe mental disorders. The aim of this study was to investigate the role of lifetime history of psychosis for neurocognitive functioning across these disorders. We asked whether neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends more on history of psychosis than diagnostic category or subtype. METHODS A sample of individuals with schizophrenia (n=102), schizoaffective disorder (n=27), and bipolar disorder (I or II) with history of psychosis (n=75) and without history of psychosis (n=61) and healthy controls (n=280), from a large ongoing study on severe mental disorder, were included. Neurocognitive function was measured with a comprehensive neuropsychological test battery. RESULTS Compared with controls, all 3 groups with a history of psychosis performed poorer across neurocognitive measures, while the bipolar group without a history of psychosis was only impaired on a measure of processing speed. The groups with a history of psychosis did not differ from each other but performed poorer than the group without a history of psychosis on a number of neurocognitive measures. These neurocognitive group differences were of a magnitude expected to have clinical significance. In the bipolar sample, history of psychosis explained more of the neurocognitive variance than bipolar diagnostic subtype. CONCLUSIONS Our findings suggest that neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders is determined more by history of psychosis than by Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) diagnostic category or subtype, supporting a more dimensional approach in future diagnostic systems.
Vemurafenib and BRAF Inhibition: A New Class of Treatment for Metastatic Melanoma

The U.S. Food and Drug Administration recently approved vemurafenib for the treatment of BRAF valine in exon 15, at codon 600 (V600E) mutant metastatic melanoma. Vemurafenib is a competitive small-molecule serine–threonine kinase inhibitor that functions by binding to the ATP-binding domain of mutant BRAF. Compared with dacarbazine chemotherapy, vemurafenib significantly improved the 6-month overall survival of patients from 64% to 84% and exhibited a response rate of approximately 50%. Median progression-free survival was also significantly improved with vemurafenib as compared with dacarbazine (5.3 versus 1.6 months, respectively), and this was consistent among groups analyzed, including age, sex, geography, Eastern Cooperative Oncology Group status, disease stage, and serum lactate dehydrogenase. The success of targeting melanoma genomics has created a paradigm shift for future drug development. Currently, the elucidation of resistant mechanisms to vemurafenib therapy remains an important area of active investigation that will shape rational drug treatments for melanoma. The development of vemurafenib, the role of BRAF targeting, and the changing landscape of treatment for melanoma provide a new foundation for clinical investigation. Clin Cancer Res; 18(1); 9–14. ©2011 AACR.
Effective chiral Lagrangian from dual resonance models.

Parameters of the effective chiral lagrangian (EChL) of orders $O(p^4)$ and $O(p^6)$ are extracted from low--energy behaviour of dual resonance models for $ \pi\pi$ and $\pi K$ scattering amplitudes. Dual resonance models are considered to be good candidates for the resonance spectrum and for hadronic scattering amplitudes in the large $N_c$ limit of QCD. We discuss dual resonance models in the presence of spontaneous and explicit chiral symmetry breaking. Obtained parameters of the EChL are used to estimate chiral corrections up to the sixth order to various low--energy characteristics of $\pi\pi$ and $\pi K$ scattering amplitudes.
Evaluation of Software Architectures Reliability Based on Hypergraph Grammar

Reliability is becoming a more and more important concern for software architectures. Previous efforts mainly use the reliability model to predict the software reliability at architecture level, but most of these work do not give the formal description of software architecture. Meanwhile, many approaches have been proposed to specify software architecture, unfortunately, few of them pay attention to reliability. In this paper, we try to bridge the gap between software architecture description and reliability model. Our work expands such idea in two directions. Firstly, we propose a reliable hypergraph grammar by extending hyperedge. Secondly, we describe the software architecture by using our reliable hypergraph grammar and predict the reliability of software architecture through the state based reliability model.
ON THE STATIONARITY OF MARKOV-SWITCHING GARCH PROCESSES

Generalized autoregressive conditional heteroskedasticity (GARCH) models with Markov-switching regimes are often used for volatility analysis of financial time series. Such models imply less persistence in the conditional variance than the standard GARCH model and potentially provide a significant improvement in volatility forecast. Nevertheless, conditions for asymptotic wide-sense stationarity have been derived only for some degenerated models. In this paper, we introduce a comprehensive approach for stationarity analysis of Markov-switching GARCH models, which manipulates a backward recursion of the model's second-order moment. A recursive formulation of the state-dependent conditional variances is developed, and the corresponding conditions for stationarity are obtained. In particular, we derive necessary and sufficient conditions for the asymptotic wide-sense stationarity of two different variants of Markov-switching GARCH processes and obtain expressions for their asymptotic variances in the general case of m-state Markov chains and (p,q)-order GARCH processes.The authors thank Professor Rami Atar for helpful discussions. The authors thank the co-editor Bruce Hansen and the three anonymous referees for their helpful comments and suggestions and in particular the referee who proposed a generalization of the proof in Appendix B. This research was supported by the Israel Science Foundation (grant 1085/05).