Miracle-dz/UniFAR-FTUs huggingface dataset:
Parameter estimation for carcass traits including growth information of Simmental beef cattle using restricted maximum likelihood with a multiple-trait model.

(Co)variance component estimates were computed for retail cuts per day of age (kilograms per day), cutability (percentage of carcass weight), and marbling score (1 through 11) using a multiple-trait sire model. Restricted maximum likelihood estimates of (co)variance components were obtained via an expectation-maximization algorithm. Carcass data consisted of 8,265 progeny records collected by U.S. Simmental producers. Growth trait information (birth weight, weaning weight, and[or] postweaning gain) for those progeny with carcass data and an additional 5,405 contemporaries formed the complete data set for analysis. A total of 420 sires were represented. Three models differing in number of traits were investigated: 1) carcass traits with growth traits, 2) carcass traits only, and 3) single trait. The final models did not include postweaning gain because of convergence problems. Parameter estimates for all three models were essentially the same. Heritability estimates were . 30, . 18, and . 23 for retail cuts per day, cutability, and marbling score, respectively. Correlations between growth and carcass traits were low except for those with retail cuts per day, which were moderate and positive. The additional information gained by adding growth traits to the carcass-traits-only evaluation lowered prediction error variances most for retail cuts per day. Little change in prediction error variances was found for cutability and marbling score. Inclusion of growth traits in future sire evaluations for carcass traits will benefit the evaluation of retail cuts per day but have considerably less effect on cutability and marbling score.
Wire-Probing Technique to Revascularize Subacute or Chronic Internal Carotid Artery Occlusion

During endovascular revascularization of subacute and chronic occlusion of the cervical internal carotid artery (ICA) it may be difficult to penetrate the lesion. Selecting the appropriate “true lumen”, a remnant of what had been the arterial lumen, at the initial step may facilitate the procedure. Because plaque at the carotid bifurcation is known to propagate from the posterior wall, a gateway to this “true lumen” should exist in the anterior side of the occluded stump. This hypothesis was studied retrospectively in our series of revascularizing ICA subacute and chronic occlusion. Eleven patients underwent endovascular revascularization for symptomatic cervical ICA occlusion. Procedures were performed by initially penetrating the occluded stump with a guidewire, followed by supporting catheter advancement through the occluded segment to secure the distal normal arterial lumen. Cases were analyzed with regard to the location of initial guidewire penetration. Eight patients underwent successful revascularization. In five cases, the entry point to the occluded stump was located at the anterior side, and in three, at the posterior side. Two posterior stump penetration cases were met with resistance in guidewire advancement, whereas penetration was smooth in the anterior cases. In addition, two posterior stump penetration cases resulted in contrast stasis in the posterior ICA wall. In our series of revascularizing cervical ICA subacute and chronic occlusion, initially targeting the anterior side of the occluded stump resulted in favorable results. This may be the result of selecting the “true lumen” at the beginning of the procedure.
An alternatively spliced isoform of PECAM-1 is expressed at high levels in human and murine tissues, and suggests a novel role for the C-terminus of PECAM-1 in cytoprotective signaling

The Ig-ITIM family member PECAM-1 is expressed in vascular and endothelial cells, and its functions include suppression of mitochondria-dependent apoptosis. Previous studies have identified distinct PECAM-1 cytoplasmic domain splice variants at the mRNA, but not protein, level. Several relatively abundant mRNA isoforms lack exon 15 (Δ15) and would theoretically encode a protein with a truncated cytoplasmic domain and a unique C-terminal sequence. Using a novel rabbit polyclonal antibody that specifically recognizes Δ15 PECAM-1, we found that the Δ15 PECAM-1 isoform was expressed in human tissues, including brain, testes and ovary. This isoform was also expressed on the cell surface of human platelets, human umbilical vein endothelial cells (HUVECs) and the Jurkat T-cell leukemia, human erythroleukemia (HEL) and U937 histiocytic lymphoma cell lines. Furthermore, murine platelets and lung lysates demonstrated abundant amounts of exon-15-deficient PECAM-1. Functional studies revealed that Δ15 PECAM-1 retains both its homophilic binding capacity and its ability to signal by means of its immunoreceptor tyrosine-based inhibitory motif (ITIM) domains. Δ15 PECAM-1 was unable, however, to protect against apoptosis induced by overexpression of Bax or treatment with the chemotherapy agent etoposide. These studies suggest a novel role for the PECAM-1 C-terminus in cytoprotective signaling and highlight a need for further characterization of expression of PECAM-1 isoforms in normal and malignant tissues.
Potential beneficial effects of Tulbaghia violacea William Henry Harvey (Alliaceae) on cardiovascular system - A review

Tulbaghia violacea William Henry Harvey (Harv. Alliaceae) is a small bulbous herb belonging to the family Alliaceae. It is used in South Africa to treat fever, colds, asthma, paralysis, and hypertension. Meanwhile, cardiovascular disease accounts for about 30 % of total global death, with most of these deaths occurring in low and middle-income countries. Furthermore, people in low-income countries are still largely dependent on plants in their surroundings for both prophylaxis and treatment of diseases, partly due to limited access to and cost of pharmaceuticals, and folkloric evidence of the potency of medicinal plants and/or local belief systems. Therefore, the present review aims to proffer possible ways by which T. violacea may improve cardiovascular outcomes. An extensive and systematic review of the literature was carried out, and relevant findings presented in this review. There is evidence that T. violacea may modulate the renin-angiotensin system, the autonomic nervous system, oxidative stress and haemostasis, with resultant protection of the cardiovascular system in both health and disease.
Modeling Adaptive Autonomous Agents

One category of research in Artificial Life is concerned with modeling and building so-called adaptive autonomous agents, which are systems that inhabit a dynamic, unpredictable environment in which they try to satisfy a set of time-dependent goals or motivations. Agents are said to be adaptive if they improve their competence at dealing with these goals based on experience. Autonomous agents constitute a new approach to the study of Artificial Intelligence (AI), which is highly inspired by biology, in particular ethology, the study of animal behavior. Research in autonomous agents has brought about a new wave of excitement into the field of AI. This paper reflects on the state of the art of this new approach. It attempts to extract its main ideas, evaluates what contributions have been made so far, and identifies its current limitations and open problems.
Data-Efficient Generalization of Robot Skills with Contextual Policy Search

In robotics, controllers make the robot solve a task within a specific context. The context can describe the objectives of the robot or physical properties of the environment and is always specified before task execution. To generalize the controller to multiple contexts, we follow a hierarchical approach for policy learning: A lower-level policy controls the robot for a given context and an upper-level policy generalizes among contexts. Current approaches for learning such upper-level policies are based on model-free policy search, which require an excessive number of interactions of the robot with its environment. More data-efficient policy search approaches are model based but, thus far, without the capability of learning hierarchical policies. We propose a new model-based policy search approach that can also learn contextual upper-level policies. Our approach is based on learning probabilistic forward models for long-term predictions. Using these predictions, we use information-theoretic insights to improve the upper-level policy. Our method achieves a substantial improvement in learning speed compared to existing methods on simulated and real robotic tasks.
A role for p53 in the response of bystander cells to receipt of medium borne signals from irradiated cells

Abstract Purpose: A number of contradictory studies have reported a role or not for p53 (protein 53) in the production of radiation-induced bystander effects. Most of these studies looked at a range of cell lines with normal or compromised p53 function. Methods: In this study, Human Colon Tumour line 116 (HCT 116) cells with confirmed wild type p53 function and a corresponding p53 null HCT 116 line were used to test for bystander signal production and response to bystander signals in a mix/match protocol using the medium transfer technique. Results: The results showed that both the null cells and the wild type cells produced bystander signals. However, only the p53 wild type cells responded to signals from either cell line. The Human Papilloma Virus transfected keratinocyte line G (HPV-G) reporter cell line used routinely in our laboratory was used to confirm that the null cells were producing signals. Conclusions: We conclude that in this system the p53 pathway is involved in response of cells to bystander signals but that signals can be produced by cells which do not have functional p53. If these results apply in vivo, they could be important in radiotherapy where tumours may have compromised p53 function but surrounding (and distant) normal tissue may have wild type functional p53.
Flow Cytometric Monitoring of Glycoprotein IIb/IIIa Blockade and Platelet Function in Patients With Acute Myocardial Infarction Receiving Reteplase, Abciximab, and Ticlopidine: Continuous Platelet Inhibition by the Combination of Abciximab and Ticlopidine

BackgroundImprovement of thrombolysis may be achieved by concomitant strong platelet inhibition. To monitor platelet function in patients with myocardial infarction (n=46) who were treated with the fibrinolytic agent reteplase, the glycoprotein (GP) IIb/IIIa blocker abciximab, and the ADP receptor antagonist ticlopidine, we developed a flow cytometric assay. Methods and ResultsBinding of abciximab to platelets was directly monitored as the percentage of platelets stained by a goat anti-mouse antibody. Blood drawn 10 minutes and 2 hours after the start of therapy with reteplase and abciximab and during the 12-hour infusion of abciximab demonstrated a maximal blockade of GP IIb/IIIa (10 minutes, 86.2±10.3%; 12 hours, 85.8±7.1%). Starting at 24 hours, abciximab binding gradually decreased (24 hours, 74.6±16.2%; 48 hours, 66.8±14.9%; 72 hours, 60.5±16.7%; 96 hours, 49.4±17.8%; 120 hours, 35.8±16.4%; and 144 hours, 29.9±15.3%). Binding of a chicken anti-fibrinogen antibody to platelets, indicating the level of functional blockade of GP IIb/IIIa, was inversely correlated with the binding of abciximab (r =−0.72, P <0.0001). In blood drawn at 10 minutes, platelet aggregation was maximally inhibited but recovered within 48 hours even if the majority of GP IIb/IIIa receptors were still blocked by abciximab. Reteplase did not influence abciximab binding and did not activate platelets, as measured by P-selectin expression, fibrinogen binding, and platelet aggregation. Platelet inhibition that was achieved during the first 24 hours by abciximab was directly maintained by additional treatment with ticlopidine. ConclusionsFlow cytometric monitoring of platelet function allows differentiation of the effects of reteplase, abciximab, and ticlopidine. The combination of abciximab and ticlopidine is an attractive therapeutic strategy that provides a fast and continuous platelet inhibition.
Integrating Multiplexing Facilities in the Set of JRMP Subprotocols

With the process of adaptation and redefinition of Java Remote Method Invocation for J2ME (Java 2, Micro Edition) environments, a reduced version of the Remote Method Invocation (RMI) came up. In this reduced version, called RMIOP, some heavy features such as multiplexing facility or its capacity to go through firewalls offered by the wire protocol, called Java Remote Method Protocol (JRMP), have been eliminated. In the present article it is explored how the recovery of the multiplexing facilities of JRMP, rejected during the RMIOP definition, can be carried out maintaining the J2ME idiosyncrasy. The article begins showing how to extend the triad of subprotocols already defined (SingleOpProtocol, StreamProtocol and MultiplexProtocol) with a new one (MultiplexConnnectionLessProtocol) equipped with special facilities to multiplex connections. It gives support for fast and light connection connectionless virtual connections generation and recycling. The paper ends with an empirical evaluation of the proposed subprotocols together with the already existing ones, in terms of end-to-end response time and the size of the frames transmitted through the network, showing the goodness of the protocols.
Energy efficiency optimization in hardware-constrained large-scale MIMO systems

Large-scale multiple-input multiple-output (MIMO) communication systems can bring substantial improvement in spectral efficiency and/or energy efficiency, due to the excessive degrees-of-freedom and huge array gain. However, large-scale MIMO is expected to deploy lower-cost radio frequency (RF) components, which are particularly prone to hardware impairments. Unfortunately, compensation schemes are not able to remove the impact of hardware impairments completely, such that a certain amount of residual impairments always exists. In this paper, we investigate the impact of residual transmit RF impairments (RTRI) on the spectral and energy efficiency of training-based point-to-point large-scale MIMO systems, and seek to determine the optimal training length and number of antennas which maximize the energy efficiency. We derive deterministic equivalents of the signal-to-noise-and-interference ratio (SINR) with zero-forcing (ZF) receivers, as well as the corresponding spectral and energy efficiency, which are shown to be accurate even for small number of antennas. Through an iterative sequential optimization, we find that the optimal training length of systems with RTRI can be smaller compared to ideal hardware systems in the moderate SNR regime, while larger in the high SNR regime. Moreover, it is observed that RTRI can significantly decrease the optimal number of transmit and receive antennas.
The privacy dyad: Antecedents of promotion- and prevention-focused online privacy behaviors and the mediating role of trust and privacy concern

Purpose – The purpose of this paper is to investigate how the business communication-related variables of reputation, communication quality and information sensitivity are mediated by trust and privacy concern to influence the privacy dyad (i.e. promotion- and prevention-focused privacy behaviors). Design/methodology/approach – Regulatory focus theory (RFT) is used to build a framework to examine antecedents of promotion- and prevention-focused privacy behaviors as well as mediators of these relationships. Hypotheses were tested using a 2 (firm reputation: strong/weak)×3 (communication quality: high/neutral/low)×2 (data sensitivity: high/low) between-subjects factorial design. Findings – The findings support the proposed model. Specifically, high reputation and communication quality increased promotion-focused behaviors and were mediated by trust. In contrast, low communication quality and high data sensitivity increased prevention-focused behaviors and were mediated by privacy concern. Consistent with RF.
Facilitating Translation Using Source Language Paraphrase Lattices

For resource-limited language pairs, coverage of the test set by the parallel corpus is an important factor that affects translation quality in two respects: 1) out of vocabulary words; 2) the same information in an input sentence can be expressed in different ways, while current phrase-based SMT systems cannot automatically select an alternative way to transfer the same information. Therefore, given limited data, in order to facilitate translation from the input side, this paper proposes a novel method to reduce the translation difficulty using source-side lattice-based paraphrases. We utilise the original phrases from the input sentence and the corresponding paraphrases to build a lattice with estimated weights for each edge to improve translation quality. Compared to the baseline system, our method achieves relative improvements of 7.07%, 6.78% and 3.63% in terms of BLEU score on small, medium and large-scale English-to-Chinese translation tasks respectively. The results show that the proposed method is effective not only for resource-limited language pairs, but also for resource-sufficient pairs to some extent.
Pomalidomide for multiple myeloma

Once characterized by a very poor outcome, multiple myeloma (MM) now has a significantly prolonged survival, with major improvements allowed by the use of ‘novel agents’: proteasome inhibitors (first-in-class bortezomib) and immunomodulatory compounds (IMiDs; first-in-class thalidomide and lenalidomide). However, the vast majority – if not all – of patients with MM ultimately end up being refractory to all existing drugs, including these efficient novel agents. There is a clear unmet medical need in this situation, which warrants the development of the next generation of proteasome inhibitors and IMiDs, as well as new drug classes. This drug profile focuses on pomalidomide, the next generation IMiD, recently approved by the US FDA and the EMA for patients with relapsed or refractory MM who have received at least two prior therapies, including lenalidomide and bortezomib, and have demonstrated disease progression on their last therapy.
Role of MicroRNA in Response to Ionizing Radiations: Evidences and Potential Impact on Clinical Practice for Radiotherapy

MicroRNAs (miRNA) are small, non-coding, RNAs with gene expression regulator roles. As an important class of regulators of many cellular pathways, miRNAs are involved in many signaling pathways and DNA damage repair processes, affecting cellular radiosensitivity. Their role has led to interest in oncological implications to improve treatment results. MiRNAs represent a great opportunity to enhance the efficacy of radiotherapy treatments—they can be used to profile the radioresistance of tumors before radiotherapy, monitor their response throughout the treatment, thus helping to select intensification strategies, and also to define the final response to therapy along with risks of recurrence or metastatization. Even though many interesting studies support such potential, nowadays most studies on patient data are limited to experiments profiling tumor aggressiveness and response to radiotherapy. Moreover many studies report different although not conflicting results on the miRNAs evaluated for each tumor type. Without doubt, the clinical potential of such molecules for radiotherapy is striking and of high interest.
A Subset of Osteoblasts Expressing High Endogenous Levels of PPARγ Switches Fate to Adipocytes in the Rat Calvaria Cell Culture Model

Background Understanding fate choice and fate switching between the osteoblast lineage (ObL) and adipocyte lineage (AdL) is important to understand both the developmental inter-relationships between osteoblasts and adipocytes and the impact of changes in fate allocation between the two lineages in normal aging and certain diseases. The goal of this study was to determine when during lineage progression ObL cells are susceptible to an AdL fate switch by activation of endogenous peroxisome proliferator-activated receptor (PPAR)γ. Methodology/Principal Findings Multiple rat calvaria cells within the ObL developmental hierarchy were isolated by either fractionation on the basis of expression of alkaline phosphatase or retrospective identification of single cell-derived colonies, and treated with BRL-49653 (BRL), a synthetic ligand for PPARγ. About 30% of the total single cell-derived colonies expressed adipogenic potential (defined cytochemically) when BRL was present. Profiling of ObL and AdL markers by qRT-PCR on amplified cRNA from over 160 colonies revealed that BRL-dependent adipogenic potential correlated with endogenous PPARγ mRNA levels. Unexpectedly, a significant subset of relatively mature ObL cells exhibited osteo-adipogenic bipotentiality. Western blotting and immunocytochemistry confirmed that ObL cells co-expressed multiple mesenchymal lineage determinants (runt-related transcription factor 2 (Runx2), PPARγ, Sox9 and MyoD which localized in the cytoplasm initially, and only Runx2 translocated to the nucleus during ObL progression. Notably, however, some cells exhibited both PPARγ and Runx2 nuclear labeling with concomitant upregulation of expression of their target genes with BRL treatment. Conclusions/Significance We conclude that not only immature but a subset of relatively mature ObL cells characterized by relatively high levels of endogenous PPARγ expression can be switched to the AdL. The fact that some ObL cells maintain capacity for adipogenic fate selection even at relatively mature developmental stages implies an unexpected plasticity with important implications in normal and pathological bone development.
Practical Confidentiality Preserving Big Data Analysis

The "pay-as-you-go" cloud computing model has strong potential for efficiently supporting big data analysis jobs expressed via data-flow languages such as Pig Latin. Due to security concerns--in particular leakage of data -- government and enterprise institutions are however reluctant to moving data and corresponding computations to public clouds. We present Crypsis, a system that allows execution of MapReduce-style data analysis jobs directly on encrypted data. Crypsis transforms data analysis scripts written in Pig Latin so that they can be executed on encrypted data. Crypsis to that end employs existing practical partially homomorphic encryption schemes, and adopts a global perspective in that it can perform partial computations on the client side when PHE alone would fail. We outline the original program transformations underlying Crypsis for reducing the cost of data analysis computations in this larger perspective. We show the practicality of our approach by evaluating Crypsis on standard benchmarks.