Miracle-dz/UniFAR-FTUs huggingface dataset:
Pharmacokinetics of darunavir in fixed‐dose combination with cobicistat compared with coadministration of darunavir and ritonavir as single agents in healthy volunteers

This study compared the bioavailability of two candidate fixed‐dose combinations (FDCs: G003 and G004) of darunavir/cobicistat 800/150 mg with that of darunavir 800 mg and ritonavir 100 mg coadministered as single agents. Short‐term safety and tolerability of the FDC formulations were also assessed. This open‐label trial included 36 healthy volunteers and assessed steady‐state pharmacokinetics of darunavir over 3 randomized, 10‐day treatment sequences, under fed conditions. Blood samples for determination of plasma concentrations of darunavir and cobicistat or ritonavir were taken over 24 hours on day 10 and analyzed by liquid‐chromatography tandem mass‐spectroscopy. Darunavir AUC24h following administration of the FDCs (G003: 74,780 ng ∙ h/mL and G004: 76,490 ng ∙ h/mL) was comparable to that following darunavir/ritonavir (78,410 ng ∙ h/mL), as was Cmax (6,666 and 6,917 ng/mL versus 6,973 ng/mL, respectively). Modestly lower C0h (1,504 and 1,478 ng/mL versus 2,015 ng/mL) and Cmin (1,167 and 1,224 ng/mL versus 1,540 ng/mL) values were seen with the FDCs. Short‐term tolerability of the FDCs was comparable to that of darunavir/ritonavir when administered as single agents. The most common adverse events reported were headache, gastrointestinal upset, or rash. Cobicistat is an effective pharmacoenhancer of darunavir when administered as an FDC. Short‐term administration of darunavir/ritonavir or darunavir/cobicistat was generally well tolerated.
Conscience verte et éducation au Burkina Faso « Nous abandonnons cela en soulevant les seaux »

This article examines the integration of a « conscience verte » (ecological sense) among primary level students who received two different types of schooling :-bilingual and uniligual. Ten of those interviewed were from a unilingual school whose curriculum dates to the time of colonization, whereas ten other students went to a bilingual school where knowledge, savoir-faire, and indigenous languages are part of the scholarly
Preparing Young Children with Disabilities for Reading Instruction: An Investigation of Effects of Early Instruction in Phonemic Awareness. Final Report.

Effects of instruction in phonemic awareness during preschool and/or kindergarten on the metalinguistic development and subsequent reading achievement of young children with disabilities were investigated in this project. The main focus of study combined a longitudinal and experimental design in which 79 preschool children with disabilities received instruction in phonemic awareness during preschool and/or kindergarten and were followed through first grade. These children received 15-minute small group instruction three times a week on phonemic awareness that focused on rhyming, syllable blending, and segmentation. Following treatment, significant effects were found favoring the experimental group on their rhyming skills and their ability to repeat sequences of phonemes. During the second year, 16 children received 2 years of instruction in phonemic awareness in preschool and kindergarten, 17 children received 1 year of instruction in preschool, 6 children received 1 year of instruction in kindergarten, and 15 children did not receive any formal instruction in phonemic awareness skills. No significant differences were found on measures of phonemic awareness. A second replication study, with a new sample of 66 preschool and kindergarten children, also failed to reveal significant experimental group gains. Appendices include the different evaluation forms. (Contains 47 references.) (CR) Reproductions supplied by EDRS are the best that can be made from the original document.
AQL: an Alignment Based Language for Querying String Databases

AQL stands for Alignment Query Language, and it is an extension of SQL. AQL allows for declarative querying of databases containing strings of characters as entries. For instance, in applications such as genomic databases, the DNA-sequences are strings, and they need to be queried based on their structure. The LIKE-operation in SQL does not go very far. Existing systems for string databases have a very ad hoc nature, usually giving the user a set of predefined simple query forms. On the other hand, there has recently been considerable theoretical advancement in the field of string databases. Several languages have been proposed, and their expressive power is becoming illuminated. However, there has been no practical demonstration of the feasibility of these languages. In this paper we describe an implementation of Alignment Calculus, a powerful string database language based on a modal logic extension of relational calculus. The implementation yields AQL. In AQL the user can write declarative string predicates in the WHERE-clause of a query. The predicates can be of an arbitrary arity, expressing for instance a unary property of a string being a palindrome, or expressing a binary property of one string being the reversal on another, and so on. The string predicates are translated into a novel form of a high level finite state automaton, and they are evaluated using an inference engine for chasing these automata. The AQL system has been implemented as an extension of a relational database management system. Our experiments show that the inference engine has the efficiency of an equivalent query computed in compiled Prolog. This is efficiency achieved already without using optimisation, something which the string queries due to their declarative nature are amenable to.
Gaseous drag on a gravitational perturber in Modified Newtonian Dynamics and the structure of the wake

We calculate the structure of a wake generated by, and the dynamical friction force on, a gravitational perturber travelling through a gaseous medium of uniform density and constant background acceleration gext, in the context of Modified Newtonian Dynamics (MOND). The wake is described as a linear superposition of two terms. The dominant part displays the same structure as the wake generated in the Newtonian gravity scaled up by a factor μ−1(gext/a0), where a0 is the constant MOND acceleration and μ the interpolating function. The structure of the second term depends greatly on the angle between gext and the velocity of the perturber. We evaluate the dynamical drag force numerically and compare our MOND results with the Newtonian case. We mention the relevance of our calculations to orbit evolution of globular clusters and satellites in a gaseous protogalaxy. Potential differences in the X-ray emission of gravitational galactic wakes in MOND and in Newtonian gravity with a dark halo are highlighted.
Perfil dos colaboradores de uma Instituição de Longa Permanência para Idosos (ILPI)

By the aging of the population was chosen the theme of this research to evaluate the conditions of senior care performed by employees in long-stay institutions. This is a qualitative and quantitative, descriptive and exploratory research that show a predominance of women with average age of 33 years, struggling to define basic concepts for the care and differences in their responses regarding the provision of services to the elderly.
L'illusoire notion de stabilité personnologique

Les psychotechniciens considerent que la personnalite est une caracteristique stable, et meme parfois innee, de l’individu. Nous situant dans une autre perspective, psychosociale, nous montrons ici, en nous basant sur les reponses fournies par differents groupes a un questionnaire type Big Five : 1) que la stabilite personnologique varie en fonction de l’insertion socio-professionnelle des individus, 2) que les stages d’insertion professionnelle ont pour objectif, et pour consequence, d’accroitre cette stabilite. Ces resultats suggerent donc que la stabilite personnologique, tout comme son axe d’analyse, sont d’abord la consequence d’un apprentissage culturel repondant a des pressions sociales ideologiquement marquees. D’ou la question, qui sera discutee, des objectifs ideologiques de ces pressions.
PAS : A Multimedia Application Framework for Next Generation Mobile Devices

Current network architecture and conventional protocols address issues relating to Data/ Voice or Video in specific rather then Multimedia as a whole entity. TCP primarily strives to handle Data, ATM for faster switching and QoS, VoIP for Voice and/or data over conventional IP. Although all these services provide multimedia services in part or whole but lack a whole dedicated framework and architecture specifically for Multimedia services. With onset of next generation mobile devices and in conjunction with high-speed net access, the need of such a framework is even more essential than ever before. With dramatic increase in portability and ease of network access it becomes natural for users to expect high quality, live multimedia applications anytime and from anywhere and to transparently remain connected and continue to use the network as they move about. This paper proposes such a framework for multimedia application for next generation mobile devices which would provide 1) a generic protocol stack for such devices 2) Provide interoperability between different protocols 3) enable end-to-end QoS based cost acceptable provision of IP multimedia services in the next generation mobile networks.
A genetics‐based description of Symbiodinium minutum sp. nov. and S. psygmophilum sp. nov. (Dinophyceae), two dinoflagellates symbiotic with cnidaria

Traditional approaches for describing species of morphologically cryptic and often unculturable forms of endosymbiotic dinoflagellates are problematic. Two new species in the genus Symbiodinium Freudenthal 1962 are described using an integrative evolutionary genetics approach: Symbiodinium minutum sp. nov. are harbored by widespread tropical anemones in the genus Aiptasia; and Symbiodinium psygmophilum sp. nov. are harbored by subtropical and temperate stony corals (e.g., Astrangia, Cladocora, and Oculina) from the Atlantic Ocean and Mediterranean Sea. Both new species are readily distinguished from each other by phylogenetic disparity and reciprocal monophyly of several nucleic acid sequences including nuclear ribosomal internal transcribed spacers 1 and 2, single copy microsatellite flanker Sym15, mitochondrial cytochrome b, and the chloroplast 23S rRNA gene. Such molecular evidence, combined with well‐defined differences in cell size, physiology (thermal tolerance), and ecology (host compatibility) establishes these organisms as distinct species. Future descriptions of Symbiodinium spp. will need to emphasize genetics‐based descriptions because significant morphological overlap in this group obscures large differences in ecology and evolutionary divergence. By using molecular evidence based on conserved and rapidly evolving genes analyzed from a variety of samples, species boundaries are defined under the precepts of Evolutionary and Biological Species Concepts without reliance on an arbitrary genetic distance metric. Because ecological specialization arises through genetic adaptations, the Ecological Species Concept can also serve to delimit many host‐specific Symbiodinium spp.
Resolving the Formation of Protogalaxies. III. Feedback from the First Stars

The first stars form in dark matter halos of masses ~106 M☉ as suggested by an increasing number of numerical simulations. Radiation feedback from these stars expels most of the gas from the shallow potential well of their surrounding dark matter halos. We use cosmological adaptive mesh refinement simulations that include self-consistent Population III star formation and feedback to examine the properties of assembling early dwarf galaxies. Accurate radiative transport is modeled with adaptive ray tracing. We include supernova explosions and follow the metal enrichment of the intergalactic medium. The calculations focus on the formation of several dwarf galaxies and their progenitors. In these halos, baryon fractions in 108 M☉ halos decrease by a factor of 2 with stellar feedback and by a factor of 3 with supernova explosions. We find that radiation feedback and supernova explosions increase gaseous spin parameters up to a factor of 4 and vary with time. Stellar feedback, supernova explosions, and H2 cooling create a complex, multiphase interstellar medium whose densities and temperatures can span up to 6 orders of magnitude at a given radius. The pair-instability supernovae of Population III stars alone enrich the halos with virial temperatures of 104 K to approximately 10−3 of solar metallicity. We find that 40% of the heavy elements resides in the intergalactic medium (IGM) at the end of our calculations. The highest metallicity gas exists in supernova remnants and very dilute regions of the IGM.
Do patterns of mental healthcare predict treatment failure in young people with schizophrenia? Evidence from an Italian population-based cohort study

Objective Little is known about the practice of predicting community-based care effectiveness of patients affected by schizophrenic disorders. We assessed predictors of treatment failure in a large sample of young people affected by schizophrenia. Methods A cohort of 556 patients aged 18–35 years who were originally diagnosed with schizophrenia during 2005–2009 in a Mental Health Service (MHS) of the Italian Lombardy Region was identified. Intensity of mental healthcare received during the first year after index visit (exposure) was measured by patients’ regularity in MHS attendance and the length of time covered with antipsychotic drug therapy. Patients were followed from index visit until 2012 for identifying hospital admission for mental disorder (outcome). A proportional hazards model was fitted to estimate the HR and 95% CIs for the exposure-outcome association, after adjusting for several covariates. A set of sensitivity analyses were performed in order to account for sources of systematic uncertainty. Results During follow-up, 144 cohort members experienced the outcome. Compared with patients on low coverage with antipsychotic drugs (≤4 months), those on intermediate (5–8 months) and high (≥9 months) coverage, had HRs (95% CI) of 0.94 (0.64 to 1.40) and 0.69 (0.48 to 0.98), respectively. There was no evidence that regular attendance at the MHS affected the outcome. Conclusions Patients in the early phase of schizophrenia and their families should be cautioned about the possible consequences of poor antipsychotic adherence. Physicians and decision makers should increase their contribution towards improving mental healthcare.
Afipia felis induces uptake by macrophages directly into a nonendocytic compartment

Afipia felis is a Gram-negative bacterium that causes some cases of human Cat Scratch Disease. A. felis can survive and multiply in several mammalian cell types, including macrophages, but the precise intracellular compartmentalization of A. felis-containing phagosomes is unknown. Here, we demonstrate that, in murine macrophages, most A. felis-containing phagosomes exclude lysosomal tracer loaded into macrophage lysosomes before, as well as endocytic tracer loaded after, establishment of an infection. Established Afipia-containing phagosomes possess neither early endosomal marker proteins [early endosome antigen 1 (EEA1), Rab5, transferrin receptor, trytophane aspartate containing coat protein (TACO)] nor late endosomal or lysosomal proteins [cathepsin D, β-glucuronidase, vacuolar proton-pumping ATPase, rab7, mannose-6-phosphate receptor, vesicle-associated membrane protein 8, lysosome-associated membrane proteins LAMP-1 and LAMP-2]. Those bacteria that will be found in a nonendosomal compartment enter the macrophage via an EEA1-negative compartment, which remains negative for LAMP-1. The smaller subpopulation of afipiae whose phagosomes will be part of the endocytic system enters into an EEA1-positive compartment, which also subsequently acquires LAMP-1. Killing of Afipia or opsonization with immune antibodies leads to a strong increase in the percentage of A. felis-containing phagosomes that interact with the endocytic system. We conclude that most phagosomes containing A. felis are disconnected from the endosome–lysosome continuum, that their unusual compartmentalization is decided at uptake, and that this compartmentalization requires bacterial viability.
A Practical QA System in Restricted Domains

This paper describes an on-going research for a practical question answering system for a home agent robot. Because the main concern of the QA system for the home robot is the precision, rather than coverage (No answer is better than wrong answers), our approach is try to achieve high accuracy in QA. We restrict the question domains and extract answers from the pre-selected, semi-structured documents on the Internet. A named entity tagger and a dependency parser are used to analyze the question accurately. User proﬁling and inference rules are used to infer hidden information that is required for ﬁnding a precise answer. Testing with a small set of queries on weather domain, the QA system showed 90.9% of precision and 75.0% of recall.
Clinical impact of preformed donor‐specific denatured class I HLA antibodies after kidney transplantation

Class I single‐antigen flow beads (SAFB) carry native and denatured human leukocyte antigen (HLA) molecules. Using a cohort of 179 class I HLA‐sensitized kidney recipients, we described incidence and clinical relevance of preformed denatured HLA donor‐specific antibodies (DSA) using two different assays: an acid‐treated SAFB assay (anti‐dHLA DSA) and the iBeads assays (SAFB+/iBeads‐ DSA). Eighty‐five class I DSA were found in 67 patients (median mean fluorescence intensity [MFI] of 1729 [range 520–13 882]). Anti‐dHLA and SAFB+/iBeads‐ DSA represented 11% and 18% of class I DSA and were mainly low MFI DSA (500–1000 MFI). Concordance between these two assays was good (90%). None of the patients with only class I anti‐dHLA DSA or only SAFB+/iBeads‐ DSA developed acute clinical antibody‐mediated rejection in the first‐year post‐transplantation, and their five‐yr death‐censored graft survival was similar to that of patients without DSA. Moreover, all these patients displayed a negative current T‐cell flow cytometry cross‐match. Therefore, both anti‐dHLA DSA and SAFB+/iBeads‐ DSA appear irrelevant, which could explain the good outcome observed in some patients with preformed class I DSA.
Subfoveal choroidal thickness in relation to sex and axial length in 93 Danish university students.

PURPOSE To investigate the association between subfoveal choroidal thickness and ocular axial length, refractive error, and blood pressure in healthy young women and men. METHODS Cross-sectional observational study of 93 eyes in 93 healthy Danish university students (mean age 24.9 ± 2.6 years). The submacular choroid was imaged using enhanced-depth imaging spectral domain optical coherence tomography. Subfoveal choroidal thickness was measured by visual inspection and manual fitting of the choroidal borderlines. Study parameters included history, best corrected visual acuity, objective refraction, interferometric ocular axial length, fundus photography, and blood pressure manometry. RESULTS The mean subfoveal choroidal thickness was 342 (±118) μm, the mean age was 24.9 (±2.6) years and the mean refractive error of participants was -1.43 (±2.9) diopters (D). In a multiple regression model, subfoveal choroidal thickness decreased by 58.2 μm (95% confidence interval [CI], 42.2-74.2 μm; P < 0.001) per mm increase in axial length adjusted for age and sex and subfoveal choroidal thickness was 62 μm (95% CI, 21-104 μm; P = 0.0039) thicker in men than in women, adjusted for age and axial length. Arterial blood pressure had no statistical effect on subfoveal choroidal thickness. CONCLUSIONS In this study of healthy young participants choroidal thickness was 18% higher in men than in women when adjusting for age and axial length. This observation may help explain the effect of sex in conditions related to choroidal thickness such as myopia, central serous chorioretinopathy, and age-related macular degeneration.
Estimation of genetic parameters for ultrasound-predicted percentage of intramuscular fat in Angus cattle using random regression models 1

The present study included 3,358 observations of 675 bulls and heifers from the Iowa State University beef cattle breeding project. Data were collected over a 3-yr period between 1998 and 2000. Each year, cattle were scanned four to six times for ultrasound-predicted percentage of intramuscular fat (UPFAT) and other ultrasound traits, starting at a minimum age of 28 wk. The objective of the current study was to estimate variance components, heritability, and repeatability of UPFAT in young bulls and heifers. Data were subjected to random-regression animal models that included fixed effects of contemporary group, fixed Legendre polynomial of age at measurement, and random regression coefficients on Legendre polynomial of age at measurement for animals’ direct genetic and direct permanent environmental effects. Phenotypic and genetic models involving different levels of polynomial fit for the animal component were considered. A
Hand Gesture Recognition using fusion of SIFT and HoG with SVM as a Classifier

This paper focuses on the hand gesture recognition using the various feature extraction techniques and SVM as a classifier. Her we have proposed the hybrid approach using SIFT and HoG combined as a feature extraction technique and gestures classification done using SVM linear kernel function.The accumulative multi class SVM method is employed in order to obtain a classification of the multiple gestures. In this computer age the hand gesture recognition is one of the important domain of the computer application wherein the human computer interaction is done without any contact. Various research are ongoing in order to produce the cost effective and robust system design in this field. We have also proposed our model with max 97% accuracy with 10 set of gesture. Keyword: SVM, HoG, SIFT, Hand Gesture recognition, Gesture, HC
La construction d'un système d'information environnemental : d'une logique de communication à une logique de valorisation

Cette these en sciences de gestion pose la question des modalites de valorisation par les marches financiers des pratiques de l'entreprise en matiere d'environnement et plus largement de "developpement durable". La decomposition du mecanisme de valorisation de la performance environnementale de l'entreprise et l'etude, pour chaque acteur implique, des methodologies de traitement de l'information nous permettent de caracteriser la nature de la demande d'information environnementale emanant des investisseurs et la nature des outils permettant d'y repondre.
Stress-responsive factor regulation in patients suffering from type 2 diabetes and myocardial infarction.

BACKGROUND/AIM Pro-free radical oxidative stresses, as well as regulatory factors, are believed to be the key players in the development of diabetes and heart-related disorders such as myocardial infarction. The aim of the present study was to highlight the role of oxidative stress-responsive factors (reactive oxygen species [ROS], super oxide dismutase [SOD], and calpain-1) in type 2 diabetes and myocardial infarction. MATERIALS AND METHODS A total of 100 type 2 diabetes patients with myocardial infarction and 50 normal individuals were selected for this analysis. The levels of ROS and activities of SOD in the serum were determined. Serum calpain-1 expression was checked using western blotting. RESULTS The serum level of ROS and the expression of calpain-1 were significantly higher while the activity of SOD was significantly lower in diabetic patients with myocardial infraction compared to normal individuals. CONCLUSION These findings suggest a possible link between decreased antioxidant (SOD) and increased ROS levels as well as calpain-1 expression, supporting the role of oxidative stress-regulatory factors in diabetes and myocardial infraction.