Miracle-dz/UniFAR-FTUs huggingface dataset:
Real-Time Statistical Clustering for Event Trace Reduction

Event tracing provides the detailed data needed to under stand the dynamics of interactions among application resource demands and system responses. However, cap turing the large volume of dynamic performance data inherent in detailed tracing can perturb program execution and stress secondary storage systems. Moreover, it can overwhelm a user or performance analyst with potentially irrelevant data. Using the Pablo performance environ ment's support for real-time data analysis, we show that dynamic statistical data clustering can dramatically reduce the volume of captured performance data by identifying and recording event traces only from representative proc essors. In turn, this makes possible low overhead, interac tive visualization, and performance tuning.
Temporal and spatial variation of atmospherically deposited organic contaminants at high elevation in yosemite national park, California, USA

Contaminants used at low elevation, such as pesticides on crops, can be transported tens of kilometers and deposited in adjacent mountains in many parts of the world. Atmospherically deposited organic contaminants in the Sierra Nevada Mountains of California, USA, have exceeded some thresholds of concern, but the spatial and temporal distributions of contaminants in the mountains are not well known. The authors sampled shallow‐water sediment and tadpoles (Pseudacris sierra) for pesticides, polycyclic aromatic hydrocarbons (PAHs), and polychlorinated biphenyls in four high‐elevation sites in Yosemite National Park in the central Sierra Nevada twice during the summers of 2006, 2007, and 2008. Both historic‐ and current‐use pesticides showed a striking pattern of lower concentrations in both sediment and tadpoles in Yosemite than was observed previously in Sequoia–Kings Canyon National Parks in the southern Sierra Nevada. By contrast, PAH concentrations in sediment were generally greater in Yosemite than in Sequoia–Kings Canyon. The authors suggest that pesticide concentrations tend to be greater in Sequoia–Kings Canyon because of a longer air flow path over agricultural lands for this park along with greater pesticide use near this park. Concentrations for DDT‐related compounds in some sediment samples exceeded guidelines or critical thresholds in both parks. A general pattern of difference between Yosemite and Sequoia–Kings Canyon was not evident for total tadpole cholinesterase activity, an indicator of harmful exposure to organophosphorus and carbamate pesticides. Variability of chemical concentrations among sites, between sampling periods within each year, and among years, contributed significantly to total variation, although the relative contributions differed between sediment and tadpoles. Environ. Toxicol. Chem. 2013;32:517–525. © 2012 SETAC
Current state and research trends on business ecosystem

In this paper, the state of art of Business Ecosystem is explored. Along with the development of service science and computing technologies, the ubiquitous information service society is coming. The organization mode of enterprises is being deeply reformed. Service Oriented Enterprise and Business Ecosystem are new types of enterprise mode in the information service society. Several ecosystem analogies are introduced, and the connection between them are analyzed. The most recent developments of Business Ecosystem are discussed, and the shortcomings are explored. An architecture of Business Ecosystem is illustrated and several research prospects are proposed.
Discrimination Prevention using Privacy Preserving Techniques

it is observed that data mining technique may come across two problems- potential discrimination and potential privacy violation. Discrimination occurs as a result of use of discriminatory datasets for data mining tasks. Privacy violation occurs if a person's sensitive information is displayed to an unauthorized entity as a result of data mining tasks. Use of privacy preserving techniques to make data privacy protected can affect the amount of discrimination caused. It is important to study the relation of privacy and discrimination in the context of data mining. In this paper, we are trying to propose a method in which privacy preserving technique can be used to prevent discrimination and we can make the original data both privacy protected and discrimination-free.
Embroidery and related manufacturing techniques for wearable antennas: Challenges and opportunities

This paper will review the evolution of wearable textile antennas over the last couple of decades. Particular emphasis will be given to the process of embroidery. This technique is advantageous for the following reasons: (i) bespoke or mass produced designs can be manufactured using digitized embroidery machines; (ii) glue is not required and (iii) the designs are aesthetic and are integrated into clothing rather than being attached to it. The embroidery technique will be compared to alternative manufacturing processes. The challenges facing the industrial and public acceptance of this technology will be assessed. Hence, the key opportunities will be highlighted.
Cell fusion induced by herpes simplex virus glycoproteins gB, gD, and gH-gL requires a gD receptor but not necessarily heparan sulfate.

To characterize cellular factors required for herpes simplex virus type 1 (HSV-1)-induced cell fusion, we used an efficient and quantitative assay relying on expression of HSV-1 glycoproteins in transfected cells. We showed the following: (1) Cell fusion depended not only on expression of four viral glycoproteins (gB, gD, and gH-gL), as previously shown, but also on expression of cell surface entry receptors specific for gD. (2) Cell fusion required expression of all four glycoproteins in the same cell. (3) Heparan sulfate was not required for cell fusion. (4) Coexpression of receptor with the four glycoproteins in the same cell reduced fusion activity, indicating that interaction of gD and receptor can limit polykaryocyte formation. Overall, the viral and cellular determinants of HSV-1-induced cell fusion are similar to those for viral entry, except that HSV-1 entry is significantly enhanced by binding of virus to cell surface heparan sulfate.
La autodeterminación de las personas con discapacidad intelectual: situación actual en España

The concept of self-determination reflects the right of individuals to act as the main characters of their own life. The exercise of this right influences significantly the quality of life of people with intellectual disabilities. This article presents a summary of the main achievements that occurred in Spain about the movement towards independence and self-determination of this group. To aim this objective, we have reviewed the most significant contributions, which have been emerging since the 90s, regarding the concept of self-determination, the instruments for evaluation and suggestions for educational intervention. Finally, we present some unresolved challenges that remain to be faced in the full development of this basic right.
An Extended Interpreted System Model for Epistemic Logics

The interpreted system model offers a computationally grounded model, in terms of the states of computer processes, to S5 epistemic logics. This paper extends the interpreted system model, and provides a computationally grounded one, called the interpreted perception system model, to those episternic logics other than S5. It is usually assumed, in the interpreted system model, that those parts of the environment that are visible to an agent are correctly perceived by the agent as a whole. The essential idea of the interpreted perception system model is that an agent may have incorrect perception or observations to the visible parts of the environment and the agent may not be aware of this. The notion of knowledge can be defined so that an agent knows a statement iff the statement holds in those states that the agent can not distinguish (from the current state) by using only her correct observations. We establish a logic of knowledge and certainty, called KC logic, with a sound and complete proof system. The knowledge modality in this logic is S4 valid. It becomes S5 if we assume an agent always has correct observations; and more interestingly, it can be S4.2 or S4.3 under other natural constraints on agents and their sensors to the environment.
Point mutations in the Drosophila hairy gene demonstrate in vivo requirements for basic, helix-loop-helix, and WRPW domains

The Drosophila pair-rule gene, hairy (h), encodes a nuclear basic helix-loop-helix (bHLH) protein that regulates embryonic segmentation and adult bristle patterning. In both cases, the h protein behaves as a transcriptional repressor. In this study, we determined the molecular nature of 12 h alleles. One mutation maps within the HLH domain, consistent with h function requiring homodimerization or heterodimerization with other HLH proteins. A second mutation lies in the basic domain, suggesting that DNA binding is required for h activity. Several mutations show that the h C terminus, in particular the WRPW domain, is also required for h activity, perhaps by interacting with other proteins to mediate transcriptional repression. We show that the h protein in Drosophila virilis closely resembles that in D. melanogaster and includes completely conserved bHLH and WRPW domains.
Transforming New Ideas into Practice: An Activity Based Perspective on the Institutionalization of Practices

We develop an activity‐focused process model of how new ideas can be transformed into front line practice by reviving attention to the importance of habitualization as a key component of institutionalization. In contrast to established models that explain how ideas diffuse or spread from one organization to another, we employ a micro‐level perspective to study the subsequent intra‐organizational processes through which these ideas are transformed into new workplace practices. We followed efforts to transform the organizationally accepted idea of ‘interdisciplinary teamwork’ into new everyday practices in four cases over a six year time period. We contribute to the literature by focusing on de‐habitualizing and re‐habitualizing behaviours that connect micro‐level actions with organizational level theorizing. Our model illuminates three phases that we propose are essential to creating and sustaining this connection: micro‐level theorizing, encouraging trying the new practices, and facilitating collective meaning‐making.
Modelling and optimal output feedback control for discrete-time systems: Multi-model approach

This paper presents a contribution to study and synthesis an optimal output feedback controller for a class of discrete-time nonlinear systems that can be represented by a Takagi-Seguno (T-S) fuzzy models. First, we interest for modelling and identification of the studied systems by using the clustering method. In particular, we use Gustafson-Kessel (GK) clustering algorithm. Second, we address the problem of optimal controller synthesis. The optimality of the proposed control technique reside on the minimization of a quadratic criterion reflecting a compromise between fast convergence of the controlled system and the control law who must be admissible formulated as a quadratic output feedback control. Thus, the gradient technique is applied to the Lagrange function in order to obtain necessary conditions to perform the optimal control matrices. Finally, this methodology is implemented on an inverted pendulum system.
Actions mediated by P2‐purinoceptorsubtypes in the isolated perfused mesenteric bed of the rat

1 The effects of adenosine 5′‐triphosphate (ATP) and its analogues on the perfusion pressure of the isolated mesenteric bed of the rat were examined in preparations at resting tone, and with tone raised by noradrenaline. 2 In the preparations at resting tone, the effect of the analogues was to produce vasoconstriction, their rank order of potency being α,β‐methylene ATP > 2‐methylthio ATP > ATP. 3 In raised tone preparations, dose‐dependent vasodilatations were produced by ATP and 2‐methylthio ATP although, at the highest doses tested, responses decreased in magnitude. The rank order of potency of the analogues in eliciting this vasodilator response was 2‐methylthio ATP > ATP, while α,β‐methylene ATP was without effect. 4 Following desensitization of contractile responses to α,β‐methylene ATP, contractile responses to ATP and 2‐methylthio ATP were abolished while their relaxant responses were potentiated. 5 Removal of the endothelium with sodium deoxycholate totally abolished the vasodilator responses and enhanced the contractile responses. 6 It is concluded that, in the rat mesentery, ATP and its analogues cause vasoconstriction via P2x‐purinoceptors and vasodilatation via P2y‐purinoceptors and that these are located on the smooth muscle and on the endothelium, respectively.
Severe Fever with Thrombocytopenia Syndrome Complicated by Co-infection with Spotted Fever Group Rickettsiae, China

During 2013–2015 in central China, co-infection with spotted fever group rickettsiae was identified in 77 of 823 patients infected with severe fever with thrombocytopenia syndrome virus. Co-infection resulted in delayed recovery and increased risk for death, prompting clinical practices in the region to consider co-infection in patients with severe fever with thrombocytopenia syndrome.
Optimal Score Level Fusion using Modalities Reliability and Separability Measures

This paper presents two optimal fusion techniques using reliability and separability measures for a multibiometric system, employing fingerprints and voice. In the first method, reliabilities of fingerprint and voice modalities are measured and the integration weights are computed as the ratio of these two reliabilities. The computed reliability ratio is then optimized against the recognition accuracy. The optimizing parameter is estimated in the training/validating phase. Latter is a multi-normalization based fusion scheme, where the separability measures are used as the integration weights to improve the performance of the biometric system. The inter/intra class separability measures and the d-prime separability measures, under various noise conditions are estimated in the training/validation stage. Performance of the proposed methods are compared with that of the baseline techniques using score level fusion. Experimental studies show that, the proposed methods improve global recognition rate and reduce the False Acceptance Rate (FAR) and False Rejection Rate (FRR) over the baseline systems. The advantage of the proposed biometric techniques is that they can be easily integrated into any multibiometric system with score level fusion and find extremely useful in applications especially with less number of available training samples.
Towards a model for risk and consent management of personal health information

Abstract —Health information custodians and networkproviders within the circle of care for a patient must meetcertain legal obligations regarding the collection, access anddisclosure of personal health information. We present aframework for consent and risk management that can be usedto help manage a patient’s consent for releasing personal healthinformation, and analyze the risk involved in handling this typeof data. A patient’s preferences for speciﬁc privacy policies(expressed in P3P) are elicited through querying, and extrainformation is inferred using a Bayesian network. A risk analysisis performed to help a custodian to make informed decisionswhen handling personal health information. Thus the custodianand provider can help each other meet their respective legalobligations, and patients are more easily able to exercise theirprivacy rights. I. I NTRODUCTION One of the major technical challenges faced by Ontarianhealth care providers under the Personal Health InformationProtection of Privacy Act, 2004 (PHIPA) is ensuring the pri-vacy and security of personal information collected from theirpatients. PHIPA governs practices to protect personal healthinformation (PHI), including consent, collection, use, disclo-sure and handling requests for access/correction to records byindividuals.Most patients deal with multiple health care workers, desig-nated as health information custodians (HICs) under PHIPA.Each HIC may need different levels of access and use to apatient’s health record in the course of providing care, all ofwhich are associated with new legal obligations under PHIPA.As a result, there are several concerns:1) How does a HIC meet their legal obligations surroundingindirect collection of PHI? 2) How does a patient retain control over access to theirPHI? How does the primary care physician (PCP) ensurethat appropriate personnel have access to the informationwhen they need it, e.g. in an emergency situation? 3) How does a HIC ensure that patient preferences sur-rounding disclosure are being acted on? Fulﬁllment of these legal obligations necessitates extractingspeciﬁc preferences from the patient. Determining qualitativeattitudes toward the handling of data, such as “I care mostabout my information being shared with third parties”, isnontrivial enough. However, determining a given patient’squantitative valuations of actions on their PHI, which isnecessary for a full risk analysis, can be a very difﬁcult task.A HIC grappling with the risks of non-compliance canuse the services of a health information network provider(HINP) to enable electronic means to manage patient PHI.
Epidemiological and immunopathological studies on Porcine parvovirus infection in Punjab

Aim: The aim of this study was to get the first-hand knowledge about the seroprevalence of Porcine parvovirus (PPV) in Punjab and a diagnosis of PPV from abortion cases of swine using gross, histopathological, and immunohistopathological techniques to observe the tissue tropism of the virus strain. Materials and Methods: Tissue samples from the reproductive tract of pig (n=32), placental tissue (n=10), and aborted fetuses (n=18) were collected from Postmortem Hall of the Department of Veterinary Pathology, GADVASU, field outbreaks and from butcher houses in and around Ludhiana. These samples were processed for histopathological and immunohistochemical (IHC) studies. For seroprevalence study, 90 serum samples of different sex and age were collected from 15 swine farms of Punjab and were subjected to indirect enzyme linked immunosorbent assay using commercial kit. Results: Overall, seroprevalence of PPV was found to be 41.1%. Sex and age related difference in the prevalence was noted. In abortion cases grossly congested and emphysematous lungs, congested internal organs with fluid in abdominal cavity and congestion in brain, changes were noted in fetuses, while diffuse hemorrhages and edema was observed in placental tissue. Histopathologically, the most frequent fetal lesions in aborted fetuses were noted in lungs, liver, and brain. IHC staining revealed PPV antigens in sections of heart, liver, lung, spleen, brain, lymph node of fetuses, placenta, and uterus of sow. Gross, histopathological, and IHC examination of the samples confirmed 5 fetus, 2 placenta and 3 female reproductive samples positive for parvovirus infection. Conclusions: Seroprevalence results may serve as a support either in prevention or control of the disease. IHC is the sensitive technique for diagnosis of PPV associated with the reproductive tract of swine and was found to supplement the gross and histopathological alterations, respectively, associated with the disease.
Raised Trappin2/elafin Protein in Cervico-Vaginal Fluid Is a Potential Predictor of Cervical Shortening and Spontaneous Preterm Birth

Early spontaneous preterm birth is associated with inflammation/infection and shortening of the cervix. We hypothesised that cervico-vaginal production of trappin2/elafin (peptidase inhibitor 3) and cathelicidin antimicrobial peptide (cathelicidin), key components of the innate immune system, are altered in women who have a spontaneous preterm birth. The aim was to determine the relationship between cervico-vaginal fluid (CVF) trappin2/elafin and cathelicidin protein concentrations with cervical length in woman at risk of spontaneous preterm birth. Trappin2/elafin and cathelicidin were measured using ELISA in longitudinal CVF samples (taken between 13 to 30 weeks' gestation) from 74 asymptomatic high risk women (based on obstetric history) recruited prospectively. Thirty six women developed a short cervix (<25 mm) by 24 weeks' and 38 women did not. Women who developed a short cervix had 2.71 times higher concentrations of CVF trappin2/elafin from 14 weeks' versus those who did not (CI 1.94–3.79, p<0.0005). CVF trappin2/elafin before 24 weeks' was 1.79 times higher in women who had a spontaneous preterm birth <37 weeks' (CI: 1.05–3.05, p = 0.034). Trappin2/elafin (>200 ng/ml) measured between 14+0–14+6 weeks' of pregnancy predicted women who subsequently developed a short cervix (n = 11, ROC area = 1.00, p = 0.008) within 8 weeks. Cathelicidin was not predictive of spontaneous delivery. Vitamin D status did not correlate with CVF antimicrobial peptide concentrations. Raised CVF trappin2/elafin has potential as an early pregnancy test for prediction of cervical shortening and spontaneous preterm birth. This justifies validation in a larger cohort.
Meganucleases and Other Tools for Targeted Genome Engineering: Perspectives and Challenges for Gene Therapy

The importance of safer approaches for gene therapy has been underscored by a series of severe adverse events (SAEs) observed in patients involved in clinical trials for Severe Combined Immune Deficiency Disease (SCID) and Chromic Granulomatous Disease (CGD). While a new generation of viral vectors is in the process of replacing the classical gamma-retrovirus–based approach, a number of strategies have emerged based on non-viral vectorization and/or targeted insertion aimed at achieving safer gene transfer. Currently, these methods display lower efficacies than viral transduction although many of them can yield more than 1% engineered cells in vitro. Nuclease-based approaches, wherein an endonuclease is used to trigger site-specific genome editing, can significantly increase the percentage of targeted cells. These methods therefore provide a real alternative to classical gene transfer as well as gene editing. However, the first endonuclease to be in clinic today is not used for gene transfer, but to inactivate a gene (CCR5) required for HIV infection. Here, we review these alternative approaches, with a special emphasis on meganucleases, a family of naturally occurring rare-cutting endonucleases, and speculate on their current and future potential.