Miracle-dz/UniFAR-FTUs huggingface dataset:
Mouse and human FcR effector functions

Mouse and human FcRs have been a major focus of attention not only of the scientific community, through the cloning and characterization of novel receptors, and of the medical community, through the identification of polymorphisms and linkage to disease but also of the pharmaceutical community, through the identification of FcRs as targets for therapy or engineering of Fc domains for the generation of enhanced therapeutic antibodies. The availability of knockout mouse lines for every single mouse FcR, of multiple or cell‐specific—‘à la carte’—FcR knockouts and the increasing generation of hFcR transgenics enable powerful in vivo approaches for the study of mouse and human FcR biology. This review will present the landscape of the current FcR family, their effector functions and the in vivo models at hand to study them. These in vivo models were recently instrumental in re‐defining the properties and effector functions of FcRs that had been overlooked or discarded from previous analyses. A particular focus will be made on the (mis)concepts on the role of high‐affinity IgG receptors in vivo and on results from antibody engineering to enhance or abrogate antibody effector functions mediated by FcRs.
CLEP_A_256838 745..755

Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; Department of Infectious Diseases, Amager Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Virus & Microbiological Special Diagnostics, Statens Serum Institute, Copenhagen, Denmark; Department of Clinical Microbiology, Slagelse Hospital, Slagelse, Denmark; Departments of Infectious Diseases and Clinical Microbiology, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Microbiology, Odense University Hospital, Odense, Denmark; Department of Clinical Microbiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Microbiology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Microbiology, Amager Hvidovre University Hospital, University of Copenhagen, Hvidovre, Denmark Background: The long-term prognosis following herpes simplex virus (HSV) central nervous
The critical use of narrative and literature in gerontology

It is now widely accepted that ’’age’’ and ’’ageing’’ are cultural concepts that are open to question. The thinking encouraged by critical gerontology has been crucially important in provoking questions about the complexities of later life, age and ageing. Similarly, the interrogation of stories of age and ageing via narrative approaches and as found in literature are increasingly recognised as an important source of knowledge for mining the intricacies of later life. There are close links between the interests of critical gerontologists and those who engage in narrative and literary gerontology. However, the potential that critical gerontology has for illuminating and probing these stories of age has often been neglected. The central argument of this article is that narrative and literary approaches to age and ageing when allied to perspectives from critical gerontology can furnish scholars with important perspectives for interpreting and re-configuring ’’age’’. The focus is upon how a genuinely dialogic relationship between critical gerontology and narrative and literary gerontology can be forged. In this way, the full potential of these stories of ageing; their epistemological status for enriching theoretical work on ageing, might be better exploited.
Surreptitious Software: Obfuscation, Watermarking, and Tamperproofing for Software Protection

This book gives thorough, scholarly coverage of an area of growing importance in computer security and is a must have for every researcher, student, and practicing professional in software protection. Mikhail Atallah, Distinguished Professor of Computer Science at Purdue University Theory, Techniques, and Tools for Fighting Software Piracy, Tampering, and Malicious Reverse EngineeringThe last decade has seen significant progress in the development of techniques for resisting software piracy and tampering. These techniques are indispensable for software developers seeking to protect vital intellectual property. Surreptitious Software is the first authoritative, comprehensive resource for researchers, developers, and students who want to understand these approaches, the level of security they afford, and the performance penalty they incur.Christian Collberg and Jasvir Nagra bring together techniques drawn from related areas of computer science, including cryptography, steganography, watermarking, software metrics, reverse engineering, and compiler optimization. Using extensive sample code, they show readers how to implement protection schemes ranging from code obfuscation and software fingerprinting to tamperproofing and birthmarking, and discuss the theoretical and practical limitations of these techniques. Coverage includesMastering techniques that both attackers and defenders use to analyze programsUsing code obfuscation to make software harder to analyze and understandFingerprinting software to identify its author and to trace software pirates Tamperproofing software using guards that detect and respond to illegal modifications of code and dataStrengthening content protection through dynamic watermarking and dynamic obfuscation Detecting code theft via software similarity analysis and birthmarking algorithmsUsing hardware techniques to defend software and media against piracy and tampering Detecting software tampering in distributed systemUnderstanding the theoretical limits of code obfuscation
Guidelines for the use and interpretation of assays for monitoring autophagy

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
FIRST REPORT OF NECTRIA HAEMATOCOCCA ASSOCIATED WITH DIEBACK OF OLIVE TREES IN TUNISIA

During a routine survey for olive diseases conducted in autumn 2013 in southern Tunisia (Bir Ali region), wilting and chlorosis of the leaves accompanied by brown-to-black discoloration of the wood in cross-sectioned twigs were observed on 3- to 10-year-old olive trees. On potato dextrose agar (PDA), a fungus was isolated from symptomatic twigs and branches with an initially white mycelium that over time became light gray-brown. This fungus was identified as Nectria sp. based on morphological characteristics and analysis of the ITS gene region (White et al., 1990). A BLAST search of GenBank database revealed 99% homology of the amplified product with a reference sequence of Nectria haematococca (strain HLJ_14, accession No. JN088237.1). Pathogenicity tests were conducted on 10 two-year old olive trees of cv. Chemlali, by placing a mycelial plug in a shallow wound on the stem of each plant. Control plants were inoculated with sterile PDA plugs. Two months post inoculation, symptoms appeared, with stems showing brown discolorations and necrotic lesions. Controls remained healthy. N. haematococca was recovered from necrotic lesions, thus fulfilling Koch's postulates. N. haematococca was held responsible for root rot of olive trees in Argentina (Barreto et al., 2003). To our knowledge this is the first report of N. haematococca as a causal agent of dieback of olive trees in Tunisia.
Parenting Style and Youth Outcome in the Uk *

We apply latent class analysis to data on parent–teenager interaction that was collected in the Youth Panel of the British Household Panel Survey. The three parenting styles thus identified ('authori-tative', 'authoritarian' and 'permissive') correspond quite closely to those proposed by child development psychologists (e.g. Baumrind, 1978, 1991). We then explore the empirical correlates of parenting style, focusing in particular on variation by family structure and par-ent's social class and education. We show that in contemporary UK parenting style is not associated with parental class or education, once family structure has been taken into account. Finally, we report consistent and strong associations between parenting style and a wide range of youth outcomes, including self-esteem and subjective well-being, health and risky behaviour, and school results and attainment.
A Summary of Deep Segmentation Techniques for Textured Images

In this paper, it is intended to summarize and discuss the methods of Segmentation for textured images in various applications of image processing. In particular, the problem of real time approaches for textured images is analyzed and their performances are studied and discussed. The main aim of segmentation is to locate objects of interest based on the available criteria and is sometimes a computer vision problem. But many important segmentation algorithms are too simple to solve this problem accurately. They compensate for this limitation with their predictability, generality, and efficiency.
Bactérias da família Enterobacteriaceae em Alphitobius diaperinus oriundos...

O cascudinho ( Alphitobius diaperinus ) e um inseto considerado como uma das maiores pragas da industria avicola no Brasil e em diversos paises no mundo. A presenca dele nos aviarios gera diversos transtornos, pois sua ingestao pelas aves, prejudica o ganho de peso e tambem podem albergar e disseminar entre as aves diversos patogenos. Coletaram-se cascudinhos em seis empresas avicolas dos Estados do Rio Grande do Sul e Santa Catarina, constando de aviarios de frangos de corte 54 amostras e de aviarios de perus, 10 amostras. Atraves de metodos de bacteriologia convencional, foram isoladas 14 especies de 10 generos de bacterias da familia Enterobacteriaceae das superficies externa e interna do cascudinho, sendo as quais: Cedecea sp. (6,89%), Citrobacter freundii (6,89%), Edwardsiella ictaluri (6,89%), Enterobacter aerogenes (5,07%), Enterobacter (Pantoea) agglomerans (0,37%), Enterobacter gergoviae (2,53%), Escherichia coli (36,96%), Klebsiella oxytoca (4,34%), Klebsiella pneumoniae (18,11%), Proteus mirabilis (8,34%), Proteus vulgaris (1,44%), Salmonella sp. (0,37%), Serratia marcescens (1,44%) e Yersinia enterocolitica (0,37%). A maior frequencia de isolados bacterianos e da diversidade de especies isoladas foi observada na superficie externa do inseto quando comparado com a superficie interna. A presenca destas enterobacterias nos cascudinhos demonstra que os mesmos sao reservatorios potenciais de bacterias patogenicas para as aves.
Evolving ideals of male body image as seen through action toys.

OBJECTIVE We hypothesized that the physiques of male action toys--small plastic figures used by children in play--would provide some index of evolving American cultural ideals of male body image. METHOD We obtained examples of the most popular American action toys manufactured over the last 30 years. We then measured the waist, chest, and bicep circumference of each figure and scaled these measurements using classical allometry to the height of an actual man (1.78 m). RESULTS We found that the figures have grown much more muscular over time, with many contemporary figures far exceeding the muscularity of even the largest human bodybuilders. DISCUSSION Our observations appear to represent a "male analog" of earlier studies examining female dolls, such as Barbie. Together, these studies of children's toys suggest that cultural expectations may contribute to body image disorders in both sexes.
The Evolution of Hom-c Homeoboxes in the Dipteran Family Drosophilidae

Forty-five new Homeotic Complex (HOM-C) homeobox sequences from six species of Drosophilidae (Dro-signal in the homeobox sequences was assessed and several aspects of sequence evolution were examined. In particular, codon bias was examined and found to exist between the drosophilid species examined here and Anopheles gambiae outgroup sequences. In addition , different patterns of codon bias were detected in homeoboxes interrupted with introns when compared to homeoboxes that are uninterrupted.
Structural Characterization and Bioactivity of Exopolysaccharide Synthesized by Geobacillus sp. TS3-9 Isolated from Radioactive Radon Hot Spring

A thermophilic, endospore-forming, and radiation resistant bacterium, strain TS3-9, was isolated from the radon hot spring. Based on phenotype, fatty acid, G + C mol %, and phylogenetic analysis, TS3-9 was assigned to the genus Geobacillus. In addition to surviving exposure to gamol/La irradiation (D10 = 10 kGy), TS3-9 produced an exopolysaccharide (EPS), the average molecular weight was approximately 3.2 × 106Da. The results of partial acid hydrolysis, GC-MS, FT-IR, and NMR analysis showed EPS was a heteropolysaccharide, composed of D-mannose, D-glucose and rhamnose as its principal monosaccharide composition in the relative proportions, 1:0.14:0.06. The uronic acids and acetyl contents (wt. %) were at 18.6 % and 6.07 %, respectively. Evaluation of antioxidant properties indicated that the EPS had good activities in scavenging hydroxyl radical, superoxide radical, and DPPH. Preliminary in vitro tests revealed that the EPS could significantly restrain the proliferation of hepatoma carcinoma cell.
Technology and Teacher Preparation in Exemplary Institutions: 1994 to 2003

Abstract In a 1994 study commissioned by the Congressional Office of Technology Assessment, Mergendoller, Johnston, Rockman, & Willis (1994) examined four exemplary institutions to identify their approaches to integrating technology into teacher education. A decade later, the field would benefit from a comparison of current approaches of infusing technology into teacher education to the 1994 findings. This study examines the approaches of the first seven teacher education programs to receive the ISTE NETS Distinguished Achievement Award. Current approaches to the process are outlined, including the identification of the key factors impacting their implementation. A comparison of the 1994 and the present study reveals that the systematic coordination of experiences in the teacher preparation program, a unifying theme throughout the program, and a shared vision of technology and teaching are instrumental and may help guide future efforts of technology integration into teacher preparation.
Does New Bank Loan at the Time of Ipo Reduce Information Asymmetry?

Using a sample of Indian IPOs over the period 2001-2008 we examine the effect of new bank loan at the time of IPO on the degree of underpricing. We find results that are consistent with previous research that commercial bank's participation in IPOs provides certification of the quality of the offer and therefore reduces the extent of underpricing. We also find lower degree of offer price revisions for IPOs with new bank loan than those IPOs without new bank loan. Our results are robust to sample selection bias.
Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts.

We have cloned and characterized LATS2, a novel mammalian homologue of the Drosophila tumor suppressor gene lats/warts. Northern blot analysis showed ubiquitous expression of mouse LATS2 (MmLATS2) mRNA, whereas expression of human LATS2 (HsLATS2) mRNA was enhanced in skeletal muscle and heart. Immunoblotting analysis of fractionated cell lysates showed HsLats2 to be a nuclear protein. We mapped the MmLATS2 gene to mouse chromosome 14 by interspecific backcross analysis. We also mapped the HsLATS2 gene (by fluorescence in situ hybridization) to the 13q11-q12 region, in which a loss of heterozygosity has been frequently observed in many primary cancers and to which the tumor suppressor genes RB and BRCA2 have also been mapped.
Modeling with BPMN and Chorda: A Top-Down, Data-Driven Methodology and Tool

In this poster paper we present a methodology, named chorda, for the modeling of business processes with BPMN. Our methodology focuses on the peculiar features of this notation: its ability to illustrate different levels of abstraction, its support for both orchestration and choreography, and the representation of data flows. In particular, this last feature has been extended to allow a better mapping of real processes, where data often plays a fundamental role. To evaluate and tune the methodology, we have developed a tool supporting it.
Image enhancement by using directional wavelet transform

The purpose of this paper is to introduce a novel image enhancement technique by using directional wavelet transform. Directional wavelet transform decomposes an image into four-dimensional space which augments the image by the scale and directional information. We show the directional information significantly improves image enhancement in noisy images in comparison with the classical techniques. Image enhancement is based on the multiscale singularity detection with an adaptive threshold whose value is calculated via maximum entropy measure. The proposed technique was tested on synthetic images at different signal-to-noise ratios and clinical images
Climate change 1995: the science of climate change.

This extensive report entitled “Climate Change 1995: The Science of Climate Change” is the most comprehensive and up-to-date assessment available for scientific understanding of human influences on the past present and future climate. Its aim is to provide objective information on which to base global climate change that will ultimately meet the aim of the UN Framework Convention on Climate Change. The report includes an overview of the factors governing climate and climate change and quantification of the sources of globally important greenhouse gases and other pollutants arising from human activities. A review of the chemical and biological processes governing their removal from the atmosphere is presented. Also included is an assessment of recent trends in climate during the industrial era which has witnessed the ever-growing impact of human activities on the global environment. The strengths and weaknesses of various climate mathematical models used by researchers for understanding the past and present climate and for calculating possible future climates are assessed. Furthermore the report discusses research aimed at the detection of human influence on the climate of the last century and presents future change projections in global climate and sea level based on a range of scenarios of future emissions of pollutants due to human activity. Finally a list of research and observational priorities needed to improve scientific understanding in key areas is presented.
Learn-as-You-Go with Megh: Efficient Live Migration of Virtual Machines

We propose a reinforcement learning algorithm, Megh, for live migration of virtual machines that simultaneously reduces the cost of energy consumption and enhances the performance. Megh learns the uncertain dynamics of workloads as-it-goes. Megh uses a dimensionality reduction scheme to projectthe combinatorially explosive state-action space to a polynomial dimensional space. These schemes enable Megh to be scalable and to work in real-time. We experimentally validate that Megh is more cost-effective and time-efficient than the MadVM and MMT algorithms.
Physical Activity Classification with Conditional Random Fields

PHYSICAL ACTIVITY CLASSIFICATION WITH CONDITIONAL RANDOM FIELDS SEPTEMBER 2015 EVAN RAY, B.S., UNIVERSITY OF MASSACHUSETTS, BOSTON M.S., UNIVERSITY OF MASSACHUSETTS, AMHERST Ph.D., UNIVERSITY OF MASSACHUSETTS, AMHERST Directed by: Professor John Staudenmayer In this thesis we develop methods for classifying physical activity using accelerometer recordings. We cast this as a problem of classification in time series with moderate to high dimensional observations at each time point. Specifically, we observe a vector of summary statistics of the accelerometer signal at each point in time, and we wish to use these observations to estimate the type and intensity of physical activity the individual engaged in as it changes over time. Our methods are based on Conditional Random Fields, which allow us to capture temporal dependence in an individual’s physical activity type without requiring us to model the distribution of the observed features at each point in time. We develop three novel estimation strategies for Conditional Random Fields, evaluate their performance on classification tasks through simulation studies and demonstrate their use in applications with real physical activity data sets.