Miracle-dz/UniFAR-FTUs huggingface dataset:
Ethnographies and Actualistic Cooking Experiments: Ethnoarchaeological Pathways toward Understanding Earth-Oven Variability in Archaeological Records

ABSTRACT This article addresses aspects of earth-oven baking, as reported in ethnohistoric and ethnographic accounts from western North America and via a series of actualistic experiments. Ethnographic and ethnohistoric accounts attest to far more variability in oven morphologies, baking times, and food types than has been identified archaeologically. Toward mitigation of this data-discrepancy, we present methods and results of building and using nine earth ovens representative of those known ethnographically and expected to be represented in archaeological records. Our experiments demonstrate that earth-oven baking in a morphological variety of facilities is readily replicated by drawing from the ethnographic and ethnohistoric literature. Successful strategies are quickly learned through trial and error. With that comes an adequate understanding of how heat energy flows in various facilities along with recognition of critical roles of temperature, moisture availability, and cooking time, thereby providing a basis for better understanding the nature of related archaeological records.
Dust storms on Mars: Considerations and simulations

Aeolian processes are important in modifying the surface of Mars at present, and appear to have been significant in the geological past. Aeolian activity includes local and global dust storms, the formation of erosional features such as yardangs and depositional features such as sand dunes, and the erosion of rock and soil. As a means of understanding aeolian processes on Mars, an investigation is in progress that includes laboratory simulations, field studies of earth analogs, and interpretation of spacecraft data. This report describes the Martian Surface Wind Tunnel, an experimental facility established at NASA-Ames Research Center, and presents some results of the general investigation. Experiments dealing with wind speeds and other conditions required for the initiation of particle movement on Mars are described and considerations are given to the resulting effectiveness of aeolian erosion.
The Role of Peripheral Nerve Surgery in Diabetic Limb Salvage

Background: Peripheral neuropathy is highly prevalent among patients with diabetes mellitus and demonstrates well-established consequences of limb loss following lower extremity ulceration, infection, and amputation and upper extremity loss of function. Symptomatic neuropathy is recognized by neuropathic pain, paresthesias, and the development of trophic limb changes. The objective of this review is to define the role of peripheral nerve surgery in the treatment of diabetic patients with upper or lower extremity symptomatic peripheral neuropathy and/or chronic postoperative pain. Methods: At locations of decreased anatomical cross-sectional area, compression points impinge on peripheral nerve fascicles, and because of a synergistic effect of the metabolic derangements of diabetes, these points of compression are implicated in nerve abnormality and dysfunction. The surgical outcomes literature following decompression is reviewed, and specific recommendations are made for appropriate surgical candidate selection. In addition, the operative techniques used in peripheral nerve surgery are outlined. Results: Peripheral nerve surgery for diabetic peripheral neuropathy is indicated when symptoms of pain, allodynia, or trophic changes persist despite optimization of medical management. Surgical treatment is considered an adjunct therapy to medical optimization and should be used when there is clinical and/or electrodiagnostic evidence of compression neuropathy or a postsurgical neuroma-related chronic pain syndrome that is refractory to conservative management. Conclusion: Review of available reports in the surgical literature demonstrates that the results of peripheral nerve surgery are promising for the prevention of limb loss in chronic diabetes mellitus, for diminishment of pain, and for restoration of sensory/motor function.
Digital Sphygmomanometer Detects Systole Diastolic Display

Hypertension. characterized by elevated blood pressure against artery walls. can be influenced by a patient's body temperature. Therefore. detecting body temperature before measuring blood pressure is essential for accurate assessment. Currently. Digital Tension and Body Temperature parameters are typically evaluated separately. To address this. we propose a novel approach to combine these parameters into a single unit. enhancing health monitoring. Utilizing MPX5050GP for blood pressure and MLX90614 for body temperature detection. Both sensors are directly connected to the Arduino UNO microcontroller. enabling seamless data processing and display on the Nextion LCD. Experimental results demonstrate the device's effectiveness. with systolic blood pressure measurements showing a Maximum error: 2.23%. minimum error: 0.53% for systolic measurements. Diastolic measurements have with a remarkable maximum error of only 4.69% and a minimal error of 1.79%. Additionally. the body temperature measurements exhibited a Achieved exceptional precision with errors as low as 0.45% and a maximum of 1.65%. Successfully completed. this design facilitates simultaneous measurement of two vital parameters. Its potential to streamline health monitoring could significantly impact hypertension management and other related conditions. Further validation and implementation in clinical settings are anticipated to enhance its utility and benefits.
Cytosolic γ-Glutamyl Peptidases Process Glutathione Conjugates in the Biosynthesis of Glucosinolates and Camalexin in Arabidopsis[W][OA]

This work demonstrates that glutathione is the sulfur donor for the biosynthesis of glucosinolates, plant compounds that play important roles in agriculture, ecology, and human health. Furthermore, it identifies the enzymes that act immediately downstream of the sulfur donation step (γ-glutamylpeptidases), thereby assigning a previously unknown in planta function to this family of enzymes. The defense-related plant metabolites known as glucosinolates play important roles in agriculture, ecology, and human health. Despite an advanced biochemical understanding of the glucosinolate pathway, the source of the reduced sulfur atom in the core glucosinolate structure remains unknown. Recent evidence has pointed toward GSH, which would require further involvement of a GSH conjugate processing enzyme. In this article, we show that an Arabidopsis thaliana mutant impaired in the production of the γ-glutamyl peptidases GGP1 and GGP3 has altered glucosinolate levels and accumulates up to 10 related GSH conjugates. We also show that the double mutant is impaired in the production of camalexin and accumulates high amounts of the camalexin intermediate GS-IAN upon induction. In addition, we demonstrate that the cellular and subcellular localization of GGP1 and GGP3 matches that of known glucosinolate and camalexin enzymes. Finally, we show that the purified recombinant GGPs can metabolize at least nine of the 10 glucosinolate-related GSH conjugates as well as GS-IAN. Our results demonstrate that GSH is the sulfur donor in the biosynthesis of glucosinolates and establish an in vivo function for the only known cytosolic plant γ-glutamyl peptidases, namely, the processing of GSH conjugates in the glucosinolate and camalexin pathways.
Serotonin-induced Na+/K+ pump stimulation in vascular smooth muscle cells. Evidence for coupling to multiple receptor mechanisms.

Exposure of cultured canine femoral artery vascular smooth muscle cells to serotonin (5-HT) caused a 3.6-fold stimulation of ouabain-sensitive 86Rb uptake. The 5-HT2 receptor antagonist, ketanserin, partly blocked the 5-HT-mediated Na+/K+ pump stimulation and the 5-HT1/5-HT2 receptor antagonist, methiothepin, completely blocked the response, suggesting that both 5-HT1 and 5-HT2 receptors play a role in the 5-HT-mediated Na+/K+ pump activation. Second messengers generated by 5-HT2 receptor-mediated phosphoinositide hydrolysis, Ins(1,4,5)P3 and diacylglycerol were implicated in the stimulatory action of 5-HT on the vascular Na+/K+ pump. Like some other contractile agonists, 5-HT activated a Na+ influx pathway which caused Na+/K+ pump stimulation by increasing the rate-limiting substrate. The maximum stimulation of Na+ influx by 5-HT was 2.5-fold. The 5-HT-stimulated Na+ influx was totally blocked by methiothepin but only 29% inhibited by ketanserin, indicating that most of the Na+ influx was mediated by the 5-HT1 receptor. The 5-HT-stimulated Na+ influx was substantially inhibited by 50 microM dimethylamiloride, suggesting that the Na+ influx pathway stimulated by 5-HT was Na+/H+ exchange. BAPTA/AM 1,2-[bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid, tetra (acetoxymethyl) ester], an intracellular Ca++ chelator, partly blocked 5-HT-stimulated Na+ influx and ouabain-sensitive 86Rb uptake, suggesting that Ca++ is an important mediator of these responses. These data suggest that: 1) 5-HT, in addition to its well known activity as a contractile agonist, can stimulate the electrogenic Na+/K+ pump which, in theory, would tend to oppose contraction. (ABSTRACT TRUNCATED AT 250 WORDS)
Development of a Chinchilla Model To Allow Direct, Continuous, Biophotonic Imaging of Bioluminescent Nontypeable Haemophilus influenzae during Experimental Otitis Media

ABSTRACT We transformed a nontypeable Haemophilus influenzae clinical isolate with a plasmid containing the luxCDABE operon driven by the H. influenzae outer membrane protein P2 promoter. Herein, we demonstrate the ability to detect bioluminescence and to monitor infection within the nasopharynges, eustachian tubes, and middle ears of chinchillas after intranasal and transbullar challenges.
METACASPASE8 (MC8) Is a Crucial Protein in the LSD1-Dependent Cell Death Pathway in Response to Ultraviolet Stress

LESION-SIMULATING DISEASE1 (LSD1) is one of the well-known cell death regulatory proteins in Arabidopsis thaliana. The lsd1 mutant exhibits runaway cell death (RCD) in response to various biotic and abiotic stresses. The phenotype of the lsd1 mutant strongly depends on two other proteins, ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1) and PHYTOALEXIN-DEFICIENT 4 (PAD4) as well as on the synthesis/metabolism/signaling of salicylic acid (SA) and reactive oxygen species (ROS). However, the most interesting aspect of the lsd1 mutant is its conditional-dependent RCD phenotype, and thus, the defined role and function of LSD1 in the suppression of EDS1 and PAD4 in controlled laboratory conditions is different in comparison to a multivariable field environment. Analysis of the lsd1 mutant transcriptome in ambient laboratory and field conditions indicated that there were some candidate genes and proteins that might be involved in the regulation of the lsd1 conditional-dependent RCD phenotype. One of them is METACASPASE 8 (AT1G16420). This type II metacaspase was described as a cell death-positive regulator induced by UV-C irradiation and ROS accumulation. In the double mc8/lsd1 mutant, we discovered reversion of the lsd1 RCD phenotype in response to UV radiation applied in controlled laboratory conditions. This cell death deregulation observed in the lsd1 mutant was reverted like in double mutants of lsd1/eds1 and lsd1/pad4. To summarize, in this work, we demonstrated that MC8 is positively involved in EDS1 and PAD4 conditional-dependent regulation of cell death when LSD1 function is suppressed in Arabidopsis thaliana. Thus, we identified a new protein compound of the conditional LSD1-EDS1-PAD4 regulatory hub. We proposed a working model of MC8 involvement in the regulation of cell death and we postulated that MC8 is a crucial protein in this regulatory pathway.
Plasma Isoflavones and the Risk of Lung Cancer in Women: A Nested Case–Control Study in Japan

Background: Although several epidemiologic studies have found that isoflavone intake assessed by questionnaire is associated with a decreased risk of lung cancer, no prospective study has investigated this association using blood concentrations of isoflavones. Methods: We conducted a nested case–control study within a population-based prospective cohort study. A total of 24,127 women aged 40 to 69 years who returned the baseline questionnaire and provided blood samples were observed from 1990 through 2006. During a median follow-up period of 13.5 years, 126 newly diagnosed lung cancer cases were identified. For each case, we selected two controls matched for age, area, smoking status, and condition of blood draw. A conditional logistic regression model was used to estimate the odds ratios (ORs) and 95% CIs of lung cancer in relation to plasma concentrations of genistein, daidzein, glycitein, equol, and total isoflavones. Results: After exclusion of 20 lung cancer cases diagnosed in the first 3 years after blood collection, an inverse association was found between plasma genistein concentration and lung cancer risk. The multivariate-adjusted OR (95% CI) of lung cancer in the highest quintile of plasma genistein concentration as compared with that in the lowest quintile was 0.31 (0.12, 0.86; P for trend = 0.085). Other isoflavones and total isoflavones were not associated with a significant decrease in the risk of lung cancer. Conclusion: Plasma genistein concentration was inversely associated with lung cancer risk in Japanese women. Impact: Our data support the previously observed association between isoflavone intake and lung cancer risk. Cancer Epidemiol Biomarkers Prev; 20(3); 419–27. ©2011 AACR.
SO2 protects the amino nitrogen metabolism of Saccharomyces cerevisiae under thermal stress

Thermal stress conditions during alcoholic fermentation modify yeasts' plasma membrane since they become more hyperfluid, which results in a loss of bilayer integrity. In this study, the influence of elevated temperatures on nitrogen metabolism of a Saccharomyces cerevisiae strain was studied, as well as the effect of different concentrations of SO2 on nitrogen metabolism under thermal stress conditions. The results obtained revealed that amino nitrogen consumption was lower in the fermentation sample subjected to thermal stress than in the control, and differences in amino acid consumption preferences were also detected, especially at the beginning of the fermentation. Under thermal stress conditions, among the three doses of SO2 studied (0, 35, 70 mg l−1 SO2), the highest dose was observed to favour amino acid utilization during the fermentative process, whereas sugar consumption presented higher rates at medium doses.
Mapping copper mineralization using EO-1 Hyperion data fusion with Landsat 8 OLI and Sentinel-2A in Moroccan Anti-Atlas

Abstract In Morocco, the oriental Anti-Atlas encompasses many valuable deposits, including that of copper (Cu) which is located in the Sidi Flah-Bouskour inlier. This deposit is known for its high importance on the national scale. The present work aims to compare the Hyperion raw and fused data for mapping Cu mineralization. After applying the pre-processing steps on the images used, the fusion (hyperspectral/multispectral) process was done using the colour normalized spectral sharpening method. Subsequently, the mineralogical mapping task was performed using the mixture tuned matched filtering and the independent component analysis methods. In the last step, a geophysical data, a field survey and spectroradiometric measurements were done for checking and validating the results obtained. The analysis showed a high performance of the fused images for mineralogical mapping. Consequently, the methodology proposed can be exploited in mineralogical mapping, and also in other remote sensing works.
Application of standardized management and effect evaluation of chronic obstructive pulmonary disease patients using the big data center of the Internet of Things

Objective Early detection, diagnosis, treatment and management of chronic obstructive pulmonary disease can lower morbidity and perhaps mortality. This study aimed to evaluate the effect of the application of standardized management against the background of the rapid development of the big data center of modern internet of things technology. Methods Participants ≥40 years of age with chronic obstructive pulmonary disease presenting at Xiamen Medical College Affiliated Haicang Hospital from October 2019 to October 2020 were selected as the observation patients based on the Internet of Things big data center for chronic obstructive pulmonary disease standardized management, and control patients from the community were selected for without down to the chronic obstructive pulmonary disease standardized management. Follow-up after 2 years of patient health records and acute episodes using the World Health Organization Quality of Life Questionnaire-Brief version to evaluate the quality of life of the two groups revealed differences. Results The results of comparative analysis of the number of acute attacks before and after follow-up in the observation and control groups after propensity score matching showed that the decrease in acute episodes before and after in the observation group was significant compared with that in the control group (t = −3.664, P < 0.001). The quality of life of chronic obstructive pulmonary disease patients indicated that the effect in the observation group was greater than that in the control group according to the World Health Organization Quality of Life Questionnaire-Brief version. Conclusion In this study, we analyzed the application of modern internet of things technology in the management of chronic obstructive pulmonary disease patients, discussed the effect of standardized management, and promoted the self-management of chronic obstructive pulmonary disease patients. The effectiveness and continuity of the standardized management model for chronic obstructive pulmonary disease implemented in Xiamen city based on the internet of things big data center were considered true and effective.
The metabolism and nuclear migration of estrogen in porcine uterus throughout the implantation process.

Gilts and sows were inseminated at estrus and sacrificed from 0 to 25 days later. Minced uterine samples were incubated for 2 h with 1 7j3-(6, 7�3 HI -estradiol ((6, 7�3 HI -E2), 3 X 10-#{176} M and Na2 So4 (\‘l X i0� M) and the labeled metabolic products were extracted and analyzed. At the same time, endometrial samples were taken for E2 nuclear receptor assays. It was found that sulfurylation, insignificant at the time of insemination (Day 0), rose to a plateau by Day 5 (average 49.2 ± 7.6%) and continued at that level for at least 25 days of pregnancy. During and after implantation, the proportions of estrone, estrone sulfate and E2 -3-sulfate were essentially the same as those seen in the cycling animal at diestrus: i.e., 18.7 ± 7.2%, 32.6 ± 6.4% and 16.6 ± 9.5%, respectively. The E2 nuclear receptor level averaged 0.32 pmoles/mg DNA from the day of insemination to Day 8 of pregnancy then dropped to 0 where it remained until Day 17. However, instead of increasing to 1.00-1.50 pmoles/mg DNA as it would at the next estrus (Packet al., 1978a), only a slight increase then occurred (average 0.09 pmoles/mg DNA), which was maintained at least until Day 25 of pregnancy. Therefore, the combined conditions of a high level of estrogen sulfotransferase and E2 dehydrogenase activities with a low E2 nuclear receptor level are characteristic of implantation and early pregnancy in the pig.
Early anxious/withdrawn behaviours predict later internalising disorders.

BACKGROUND The aim of the study was to examine the association between anxious/withdrawn behaviours at age 8 and the development of internalising disorders in adolescence and young adulthood (ages 16-21). METHODS Data were gathered over the course of a 21-year longitudinal study of a birth cohort of over 1,000 New-Zealand-born young people. Over the course of the study, data were gathered on: (a) anxious/withdrawn behaviour at age 8; (b) anxiety disorders and major depression at ages 16-18 and 18-21; (c) a range of potential confounding factors, including measures of adversity and family factors during childhood. RESULTS Increasing anxious/withdrawn behaviour at age 8 was associated with increasing risks of social phobia; specific phobia; panic/agoraphobia; and major depression during adolescence and young adulthood. These associations persisted after adjustment for a series of confounding social, childhood, and family factors. CONCLUSIONS Anxious/withdrawn behaviour in childhood is associated with elevated rates of anxiety disorders and major depression during adolescence and young adulthood. These data are consistent with, and extend, previous clinical and epidemiologic findings, by showing consistent linkages between childhood anxious/withdrawn behaviours at age 8 and increased risk for anxiety disorders and depression at ages 16-18 and 18-21 among young persons in the community. These results may point to the need to provide support and possibly intervention to children showing early anxious or withdrawn behaviours.
"Dinámica y estructura poblacional de Phyllodactylus sentosus Dixon & Huey, 1970, en la Huaca Pucllana-Lima, Perú."

The gecko, Phyllodactylus sentosus, is endemic to Peru and is the only member of the family Phyllodactylidae which is deemed threatened under the Peruvian legislation. Its distribution is mainly known in the form of subpopulations in seven separate archaeological sites, not connected with one another, within the city of Lima. The population dynamics and structure of P. sentosus were analyzed in the Huaca Pucllana, a pre-Incan temple, located in the Miraflores district in Lima. The analysis comprised monthly assessments of capture and recapture. Female, male and juvenile geckos were marked, measured and identified. The population varied on a seasonal basis and the size class structure did not follow a normal distribution. Most organisms were juvenile and distributed into the lower size classes. The adults presented a greater spread. Throughout the months of the assessment, females, males and juvenile geckos were recorded. The females were significantly larger than males. Therefore, there is sexual dimorphism in size. The mating season occurred from November through February and most births took place from February through March. P. sentosus showed a sex rate of 1(♀) : 0,9(♂). The results of this study feature important aspects in regard to the life history of P. sentosus, providing useful information for the decision making about the management and conservation of this threatened species. Tags: Capture and recapture, population dynamics, population structure, Phyllodactylus sentosus, gecko of Lima, Peru
Adaptive ECG interval extraction

ECG intervals such as QRS, QT and PR provide significant information and are widely used as clinical parameters for diagnosing cardiac diseases. This paper presents a novel QRS detection technique based on Curve Length Transform (CLT) and a refined delineation of P-wave and T-wave using Discrete Wavelet Transform (DWT). The proposed technique was verified using the PhysioNet database. The QRS detection achieved a sensitivity of 98.59% and a positive predictivity of 97.86%. The QRS duration, QT interval and PR interval had a mean error of -1.56± 28.8ms, -5.39± 42.4ms and 0.86± 40.3ms respectively. The proposed algorithm is computationally efficient and is simpler to implement in hardware, hence, will lead to a faster execution time, smaller design area and consequently low power consumption.