Miracle-dz/UniFAR-FTUs huggingface dataset:
Poisoning with antidepressants.

and in time that too will be achieved as their knowledge becomes more specialised and therefore less available generally. There was a time when every physician could call himself a cardiologist or a gastroenterologist, but not now. Geriatrics is not a specialty at present in that it could be practised adequately by the general physician if he wanted to, but already there are important aspects of it-for example, rehabilitation and drug therapy-in which he lacks the available specialist knowledge. Geriatric medicine has advanced more rapidly than most other branches and has yet plenty of time in hand to achieve the specialty rating. Even then the prejudice will remain. Anti-elderly, anti-geriatrician prejudice within medicine is a gut reaction, primitive, unreasonable, arrogant, and strong. For this reason Mr Cross's solution is naive and cannot work, quite apart from the fact that it is also irrational. His "gerontologist" and his "physician to the elderly" are puny figures compared even with the present-day geriatrician. Teaching and research in clinical medicine become increasingly phoney when undertaken apart from clinical practice. As for the suggestion that the general physician will take over a chronic ward as well as his acute ward, thereby gaining the ideal complete facility, Mr Cross can rapidly disillusion himself by surveying the number of physicians who have ever been inside a chronic ward. When general medical staff are responsible for the management of chronic wards these wards often become disaster areas used for dumping difficult patients with unsolved problems, receiving the token weekly visit by a junior member of staff, and denied time and imagination, with the result that nursing staff morale is invariably low, work becomes drudgery, and care second-ratz. Whatever their faults geriatricians have grasped the common nettle of chronic illness and disability while many physicians continue to hunt the higher slopes for the tufted saxifrage which grows occasionally in the rarefied air, and who can blame them when their training prepares them for it and the power and the glory still seem to lie in that direction. Students draw the obvious conclusion and hasten after them.
Ventilatory capacity during exposure to western red cedar.

Recent clinical and investigation evidence implicating the dust of Western red cedar (Thuja plicata) as the cause of a number of cases of asthma led to a survey of 49 men working exclusively with this timber. The study revealed three subjects with asthma (a fourth had recently resigned) and four with rhinitis, indicating that clinical effects are not rare. Small but significant decreases, of approximately 100 ml, were found in the forced expiratory volume at one second (FEV1.0) on each of two working days in the 30 more heavily exposed subjects, especially in smokers who had a productive cough upon request. No such changes occurred in subjects with little or no exposure. The mechanism producing this reduction is uncertain, but may have been a nonspecific reaction in men already subject to “bronchitis. ”
2 Quaternion-Kähler geometry from projective superspace

We generalize the results of hep-th/0701214 about the covariant c-map to include the perturbative quantum corrections. We also perform explicitly the superconformal quotient from the hyperkähler cone obtained by the quantum c-map to the quaternion-Kähler space, which is the moduli space of hypermultiplets. As a result, the perturbatively corrected metric on the moduli space is found in a simplified form comparing to the expression known in the literature.
p130 Crk-Associated Substrate (CAS) in Vascular Smooth Muscle

Vascular smooth muscle is a key effector in the wall of blood vessels during the pathogenesis of hypertension. Various factors directly elicit smooth muscle cell contraction, migration, growth, and hypertrophy, which lead to the progression of hypertension. Crk-associated substrate (CAS), the first discovered member of the adapter protein CAS family, has recently emerged as a critical cellular component that regulates smooth muscle functions. In this review, the molecular structure and protein interactions of the CAS family members are summarized. Evidence for the role of CAS in the regulation of vascular smooth muscle contractility, cell migration, hypertrophy, and growth is presented. Regulation of CAS by novel tyrosine kinases/phosphatases and unique downstream signaling partners of CAS are also discussed. These new findings establish the important role for CAS in regulating vascular smooth muscle functions. The CAS-associated processes may be new biological targets for the development of new treatment of cardiovascular diseases such as hypertension.
A Petri Net-based Model for Web Service Composition

The Internet is going through several major changes. It has become a vehicle of Web services rather than just a repository of information. Many organizations are putting their core business competencies on the Internet as a collection of Web services. An important challenge is to integrate them to create new value-added Web services in ways that could never be foreseen forming what is known as Business-to-Business (B2B) services. Therefore, there is a need for modeling techniques and tools for reliable Web service composition. In this paper, we propose a Petri net-based algebra, used to model control flows, as a necessary constituent of reliable Web service composition process. This algebra is expressive enough to capture the semantics of complex Web service combinations.
Overview of emerging concepts in metabolic surgery.

Michel Murr, MD, FACS Arash Rafiei, MD Habib Ajami, MD Tannous K Fakhry, MD Introduction There is now a worldwide epidemic of obesity. According to the Centers for Disease Control and Prevention, the prevalence of obesity among all age groups has increased significantly since 1990; about two-thirds of US adults are overweight or obese. Obesity is classified according to body mass index (BMI); overweight is a BMI of 25 to 29.9 kg/m, class I obesity is a BMI of 30 to 34.9 kg/m, class II obesity is a BMI of 35 to 39.9 kg/m, and class III obesity is a BMI of ≥40 kg/m. The 1998 National Heart, Lung, and Blood Institute guidelines recommended a combination of low-calorie diet, exercise, and behavioral therapy as first-line treatment for obesity. Such a comprehensive approach results in weight loss of 8% to 10%; nonetheless, weight regain is common after two years. Metabolic or bariatric surgery induces durable and sustainable weight loss. The 1991 National Institutes of Health Consensus Conference Statement defined the criteria for bariatric surgery as a BMI of ≥40 kg/m or of ≥35 kg/m with comorbidities (Tables 1 and 2). The most recent guidelines of the American Diabetes Association state that “bariatric surgery should be considered for adults with BMI >35 kg/m and type 2 diabetes, especially if the diabetes is difficult to control with lifestyle modification and pharmacologic therapy. ” Surgical candidates must have tried other weight-loss modalities (diet, exercise, etc) before consideration of bariatric surgery. It is estimated that about 3% of the US population, or approximately five million people, meet the weight criteria for bariatric surgery. The prevalence of serious comorbidities such as metabolic syndrome is 39% among patients undergoing bariatric surgery. More importantly, among individuals with type 2 diabetes, 85% are overweight and 55% are obese. The Nurses’ Health Study demonstrated that individuals with a BMI of 35 kg/m had a 40-fold increase in their likelihood of developing diabetes. The link between diabetes and obesity is due to induction of insulin resistance by excess adipose tissue and generalized low chronic inflammation. The role of metabolic surgery in the treatment of obesity is well established. The Swedish Obese Subjects (SOS) study demonstrated that metabolic surgery induces remission of diabetes in 69% of obese-diabetic patients. Furthermore, in a meta-analysis of 136 studies, the proportion of patients who had diabetes before surgery (median, 11%; range, 3%–100%) and who showed fewer effects from or resolution of diabetes after surgery ranged from 64% to 100% (median, 100%). Improvements in insulin sensitivity within the first few days after Roux-en-Y gastric bypass (RYGB), before any measurable weight loss, is commonly observed, and has been maintained at
High Mobility Group Box Protein-1 in Wound Repair

High-mobility group box 1 protein (HMGB1), a member of highly conserved non-histone DNA binding protein family, has been studied as transcription factor and growth factor. Secreted extracellularly by activated monocytes and macrophages or passively released by necrotic or damaged cells, extracellular HMGB1 is a potent mediator of inflammation. Extracellular HMGB1 has apparently contrasting biological actions: it sustains inflammation (with the possible establishment of autoimmunity or of self-maintaining tissue damage), but it also activates and recruits stem cells, boosting tissue repair. Here, we focus on the role of HMGB1 in physiological and pathological responses, the mechanisms by which it contributes to tissue repair and therapeutic strategies base on targeting HMGB1.
Effects of intensive low-salt diet education on albuminuria among nondiabetic patients with hypertension treated with olmesartan: a single-blinded randomized, controlled trial.

BACKGROUND AND OBJECTIVES The antiproteinuric effect of a renin-angiotensin-aldosterone system blockade can be magnified by dietary salt restriction. This study sought to determine the effect of intensive low-salt diet education on BP and urine albumin excretion in nondiabetic patients with hypertension and albuminuria. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS This study was conducted between March of 2012 and March of 2013 as an open-label, randomized, controlled trial. After a run-in period of 8 weeks, all patients received the angiotensin II receptor blocker olmesartan (40 mg daily). Patients were then divided into two groups. One group was treated for another 8 weeks with angiotensin II receptor blocker plus conventional low-salt diet education, and the other group was treated for 8 weeks with angiotensin II receptor blocker plus intensive low-salt diet education. The final analyses was performed with 245 completed patients. RESULTS The amount of daily albuminuria was significantly decreased from 0 (566.0 [25.0-5398.6] mg/d) to 8 weeks (282.5 [16.1-4898.5] mg/d; P<0.001). From 8 to 16 weeks, the 24-hour urinary sodium excretion was decreased by 36.0±5.9 mmol/d in the intensive education group and 8.8±4.9 mmol/d in the conventional education group (interaction P<0.001). Patients who completed intensive low-salt diet education exhibited greater decreases in urinary albumin excretion than the control group (change in albuminuria from 8 to 16 weeks, -154.0 versus 0.4 mg/d; P=0.01). Urinary albumin excretion tended to decrease as the 24-hour urinary sodium excretion amount decreased (R=0.32; 95% confidence interval, 0.20 to 0.43; P<0.001). CONCLUSIONS The 24-hour urinary albumin excretion was decreased more in patients in the intensive low-salt diet education group than patients in the conventional education group. Weekly intensive education on a low-salt diet would be a suitable method for clinical practice.
Spontaneous motor tempo and rhythmical synchronisation in 2½- and 4-year-old children

Spontaneous motor tempo and rhythmical synchronisation were studied in 2½- to 4-year-old children. Children were tested in three sessions, each of which included three consecutive tasks: first, spontaneous manual tapping tempo, second, synchronisation to external tempo, followed by spontaneous manual tapping tempo again. Results showed that regular spontaneous manual tapping tempo could be observed in children as young as 2½ years. Moreover, children could slow down their tap rhythm when the auditory stimulation became slower. Anticipating sound and adjusting their motor response to time interval was easier for children at the age of 4 years than for younger children. Consequently, it seems easier for the former to estimate the time interval than for the latter. Data referring to different clock models and new perspectives to conduct research on temporal studies in child development will be discussed.
Optical and Piezoelectric Properties of Mn-Doped ZnO Films Deposited by Sol-Gel and Hydrothermal Methods

Nowadays, multifunctional materials are of high interest due to their ability to be used in different applications by controlling one or two parameters (e.g., morphology and/or dopant). Zinc oxide is an intensive-studied material because of its large usability. Recently, we have shown that the conduction, transparency, and charge carrier concentration of ZnO can be controlled by changing the dopants, leading to promising materials as transparent conductive oxide films. In this work, sol-gel (SG) and hydrothermal (HT) methods were used separately or in combination in order to obtain ZnO films doped with Mn (1, 2, and 5%) for possible application in transparent optoelectronics or as piezoelectric materials. The manganese (Mn) dopant in the form of anhydrous manganese acetate was used to obtain Mn-doped ZnO films. ZnO hydrothermal (HT) growth was made on a previously ZnO seed layer, formed by sol-gel method. The Mn-doped ZnO films were deposited on microscope glass and on Pt/Ti/SiO2/Si substrates. A comparative characterization of the films for their structure, morphology, and optical and piezoelectric properties was achieved. SG films exhibit equiaxed nanoparticles, with diameters around 50 nm, while the films prepared by HT show a homogeneous morphology consisting of uniform 1D nanorods, sized about 30 nm diameter and 200–300 nm length. XRD diffractograms evidenced the presence of zincite phase (wurtzite structure hexagonally close packed), with an improvement in crystallinity of the HT films (compared with SG ones), which present a stronger tendency to be oriented along (002) plane (c-axis) at 2% at Mn. Spectroscopic ellipsometry shows that the films obtained by SG are much thinner than the ones obtained by HT and that the refractive index is increasing with the percent of dopant. The band gap energy was found to decrease with the Mn doping level from 3.28 eV (undoped ZnO) to 3.10 eV (ZnO doped with 5 at% Mn) for the samples deposited on Pt/Ti/SiO2/Si. The maximum transmission is found for the undoped ZnO film and decreases with Mn concentration but remains over 78% in the visible range. From the piezoelectric tests, it was found that the d33 coefficient is much larger for the HT samples in comparison with the SG samples, especially for 2 and 5 at% Mn. The optical and piezoelectric results could be of interest for applications in optoelectronic or piezoelectric devices.
TLR9 mRNA expression is upregulated in patients with active ulcerative colitis.

To the Editor: TLR9 is a member of the innate immunity Toll-like receptors (TLRs) family that recognizes bacterial unmethylated CpG DNA motifs. In experimental models of colitis, activation of TLR9 with artificial CpG ODN has proven beneficial. Also, TLR9 was reported to mediate interleukin 8 (IL8) production in colonic epithelial cell lines in response to DNA from pathogenic bacteria. Genetic studies have shown that polymorphisms in TLRs may participate in both Crohn’s disease (CD) and ulcerative colitis (UC). In particular, TLR9 ( 1237T/C) polymorphism has recently been implicated in the development of IBD. Recently, Ghadimi at al showed that TLR9 activation by commensal-origin bacteria DNA is important in the induction of IL-8 production. To our best knowledge, this is the first study designed to evaluate TLR9 gene expression from rectal biopsies in patients with UC. We quantified mRNA levels in rectal biopsy specimens from UC patients and healthy controls. Forty-nine rectal biopsies were obtained from a first cohort group that consisted of 38 UC patients (22 active and 16 remission) as well as 11 healthy controls. All individuals were assessed for TLR9 and IL-6 mRNA transcript levels relative to RPLP0 constitutive gene using real-time reverse-transcription polymerase chain reaction (RT-PCR) using LNA TaqMan probes from Roche (Nutley, NJ) in combination with target gene-specific primers (primer sequences: TLR9 50-TGTGAAGCATG GTTCCCTGT-30, 50-GAGAGACAGCG GGTGCAG-30, IL6 50-GCCCAGCTAT GAACTCCTTCT-30, 50-GAAGGCAGC AGGCAACAC-30 RPLP0 50-ACAGGG CGACCTGGAAGT-30, 50-GGATCTGC TGCATCTGCTT-30). In order to confirm these findings, we also studied a second cohort group that consisted of 36 UC patients (27 active, 9 remission) and 22 healthy controls. Both cohorts were also assessed for TLR9 and IL-6 mRNA relative to RPLP0 as previously described. All results were calibrated to the same control sample performed in all experiments in both cohorts. Also, to solve a possible bias from housekeeping selection both b-actin (50-CCAACCGC GAGAAGATGA-30, 50-CCAGAGGCG TACAGGGATAG-30) and GAPDH (50AGCCACATCGCTCAGACAC-30, 50-G CCCAATACGACCAAATCC-30) were also assessed in the second cohort group. Analysis of the whole sample showed that TLR9 mRNA levels were found significantly increased in the UC active group when compared with healthy controls and patients with UC in remission and healthy controls (Fig. 1A). A good correlation was found between TLR9 with IL6 (r 1⁄4 0.603 P < 0.001) (Fig. 1B). Results from the
Systemic Therapy for Hepatocellular Carcinoma: The Issue of Treatment Stage Migration and Registration of Progression Using the BCLC-Refined RECIST

Abstract Recent advancements have improved the management of patients with liver cancer. Results of studies have informed how to stage and decide the optimal treatment option for each patient with an adequate balance between risks and benefits. The Barcelona Clinic Liver Cancer (BCLC) staging and treatment strategy has been widely endorsed for this purpose. This is not a rigid system: One of the key aspects in the management of patients is the optimal timing for systemic treatment initiation and for declaring tumor progression and/or treatment failure. Some patients at intermediate or even early stage may be considered for systemic therapy as options of higher priority may have failed or may not be feasible. Sorafenib is the sole systemic agent that has shown efficacy in phase 3 trials. Other agents (sunitinib, brivanib, linifanib, everolimus, ramucirumab) have failed in terms of safety and/or survival benefit. Optimal sorafenib administration and adequate adherence of the patients are crucial requirements to obtain the benefits of the drug. Because development of adverse events has been shown to correlate with better outcome, careful dose adjustments should be in place while avoiding unnecessary treatment interruption. Furthermore, recent studies have shown that progression at imaging may not translate in poor prognosis and that treatment beyond progression may be considered if there is no option for a second-line research trial. In this review, the authors examine all of the controversial aspects that affect treatment initiation and maintenance, how response to treatment should be evaluated, and define the needs that are faced by current research.
The Linguistic Basis of Text Generation

This study presents an original and penetrating analysis of the complex problems surrounding the automatic generation of natural language text. Laurence Danlos provides a valuable critical review of current research in this important and increasingly active field, and goes on to describe a new theoretical model that is thoroughly grounded in linguistic principles.The model emphasizes the semantic, syntactic and lexical constraints that must be dealt with when establishing a relationship between meaning and form, and it is consideration of such linguistic constraints that determines Danlos' generation algorithm. The book concludes with a description of a generation system based on this algorithm which produces texts in several domains and also a system for the synthesis of spoken messages from semantic representations.The book is a significant addition to the literature on text generation, and will be of particular interest to all computational linguists and AI researchers who have wrestled with the problem of vocabulary selection.
Sensory feedback control for space manipulators

The positioning control problem of the end tips of space manipulators which have no fixed bases is investigated. According to the momentum-conservation law, the system is represented by a nonholonomic model. Thus, the conventional control method for industrial robots, based on a local feedback at each joint, is not applicable when the end tip must be positioned at a floating target. For this problem, the sensory feedback control scheme is based on the artificial potential defined in the sensor coordinate frame. The generalized Jacobian plays an important role in determining the control torque of each joint from the data of the external sensors. This scheme is simple, and the stability of the system is strictly assured. The approximate Jacobian, which needs less computation and less parameter identification, is shown to work well. <<ETX>>
Professional practices and perception towards rational use of medicines according to WHO methodology in United Arab Emirates

Inappropriate prescribing reduces the quality of medical care and leads to a waste of resources. No study has been reported concerning rational drug use in United Arab Emirates, UAE, recently. Objectives assessing patterns of use and defining problems regarding the rational drug use. Setting baseline situational analysis study for practices in the health care system relevant to drug use. Method A descriptive pilot study, consisting of pharmacists, physicians and patients (100 of each of category) from four private hospitals, (12) medical clinics, (80) community pharmacies in addition to 150 prescriptions. A questionnaire of three sections was designed to include WHO indicators regarding patients, facility and prescribing patterns that are relevant to rational drug use was carried out in four emirates of the UAE in the period December 2008-Febreuary 2009. Results Consultation and dispensing times were 10 (SD=2.75) min and 68 (SD=9.7) seconds, respectively. Average no. of drugs per prescription was (2.9 + 0.97), % of prescriptions using generic name (7.35%), % of antibiotic containing prescriptions (31.1%), % of injection containing prescriptions (2.9%), adherence to Standard Treatment Protocols (46%), adherence to the essential drug list (64%), patient’s knowledge of correct dosage (55%), adequately labeled drugs (45%), patient’s information (65%). Conclusions Several areas of deficiency in rational drug use had been defined in the private sector through UAE that can be remedied through adopting several strategies such as adherence to national standard treatment guidelines and essential drug list based on treatments of choice, interaction between health care system and providing drugs information to consumers.
Wisconsin Wind Tunnel II: a fast, portable parallel architecture simulator

To analyze new parallel computers, developers must rapidly simulate designs running realistic workloads. Historically, direct execution and a parallel host have accelerated simulations, although these techniques have typically lacked portability. Through four key operations, the Wisconsin Wind Tunnel II can easily run simulations on Sparc platforms ranging from a workstation cluster to an asymmetric multiprocessor.